NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE There is an urgent clinical need to develop non-addictive analgesic agents for abdominal pain in gastrointestinal disease patients, as current medications are not effective for all individuals. The enzyme glutamate carboxypeptidase II (GCPII) has well-defined functions in central and peripheral pain pathways and we have recently discovered that dysregulated GCPII in the enteric nervous system may also contribute to abdominal pain. This proposal will expand our knowledge regarding GCPII’s functions in abdominal pain and inform future drug development efforts.

PI_NAMEs: PRADHAN, MANISHA  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Abdomen;Abdominal Pain;Ablation;Accounting;Acute;Afferent Neurons;Analgesics;Biological Assay;Biological Markers;Biological Models;Biology;Biosensor;career;Cell Line;cell type;Cells;Central Nervous System;central pain;Chemoreceptors;Chronic;Clinical;Colon;Colorectal;colorectal distension;Communication;CRISPR/Cas technology;Development;Disease;drug development;Electromyography;Endocrine;Enteric Nervous System;Enterobacteria phage P1 Cre recombinase;Enteroendocrine Cell;Enzyme-Linked Immunosorbent Assay;Enzymes;Epithelium;Evaluation;FOLH1 gene;Foundations;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Modified;Genetic;glucagon-like peptide 1;glutamatergic signaling;Glutamates;gut-brain axis;Hormones;Human;Hydrolysis;Hypersensitivity;ileum;Immunohistochemistry;in vivo;in vivo Model;Individual;Inflammatory;Inflammatory Bowel Diseases;inflammatory pain;inhibitor;Irritable Bowel Syndrome;knock-down;Knockout Mice;Knowledge;Laboratories;LoxP-flanked allele;Measures;Mediating;Metalloproteases;Methods;Modeling;Modification;mouse development;mouse model;Mus;Musculoskeletal Pain;N-acetylaspartylglutamate;neurofilament;Neuroglia;Neurons;Neuropeptides;neurotransmission;Neurotransmitters;new therapeutic target;Nociception;novel;novel therapeutics;Pain;Pain Measurement;pain model;pain signal;painful neuropathy;Pathway interactions;Patients;Peripheral Nervous System;peripheral pain;Pharmaceutical Preparations;Phenocopy;Phenotype;Piezo 2 ion channel;Population;pre-clinical;promoter;protein expression;Publishing;Reaction;Reporter;Reporting;Research;Research Personnel;response;Rodent;Rodent Model;Role;sensor;Signal Transduction;small molecule;Solid;Stains;Stimulus;Symptoms;Synapses;Synapsins;System;Testing;therapeutic target;Time;Training;trinitrobenzene sulfonic acid induced colitis;Visceral;Visceral pain;Western Blotting;Work

PROJECT_TITLE: Role of Gastrointestinal GCPII in Visceral Pain Signaling


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PI_NAMEs: LEBEAU, RICHARD THOMAS (contact)

PROJECT_TERMS: Address;Anxiety;anxiety treatment;Awareness;care systems;Clinical;college;Communities;community college;Community Health Aides;contextual factors;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;cultural competence;Data;Data Collection;Demographic Factors;Demographic Impact;design;digital;digital intervention;digital mental health;digital treatment;Drops;Educational Status;Enrollment;ethnic minority;ethnic minority population;Ethnic Origin;Expectancy;experience;Feedback;Focus Groups;functional improvement;Gender;Goals;health disparity;Health Resources;improved;Individual;Intervention;Latinx;Latinx population;Literature;Lived experience;Los Angeles;Matched Group;Mediation;member;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;Outcome;Participant;peer coaching;Perception;premature;prevent;programs;Provider;Race;racial minority;racial minority population;Randomized;recruit;Research;Sampling;satisfaction;screening;service utilization;Services;social stigma;Student recruitment;student training;Students;Supervision;symptomatic improvement;Symptoms;Training;treatment effect;university student;uptake;Work

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Food Allergies;Neurosciences;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: NARRATIVE Food allergy has been associated with neuropsychiatric and neurodegenerative disorders, although how the immune disorder affects brain function is not clear. Our recent studies with a mouse model of cow’s milk allergy have indicated that allergic mice exhibit altered behavior, and brain pathologies are evident especially after repeated allergen consumption. Under the hypothesis that allergen-activated immune cells enter the brain to elicit damage-producing neuroinflammation, we aim to determine whether preventing the activation and migration of the immune cells will decrease these allergy-associated changes in the brain and behavior.

PI_NAMEs: NAGAMOTO-COMBS, KUMI  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acetates;Acute;Adoptive Transfer;Adult;Adverse effects;Affect;Allergens;Allergic;Allergic Reaction;Alzheimer's Disease;Anaphylaxis;Animal Model;Antibodies;Anxiety;Astrocytes;Attenuated;autistic behaviour;Axon;Behavior;behavior change;behavior test;Behavioral;beta Lactoglobulin;Blood;Blood Vessels;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain Pathology;Cattle;cell motility;Cells;Central Nervous System;Central Nervous System Diseases;chemokine;Child;Chronic;Chymase;Circulation;Clinical;Clinical Research;Cognitive;cognitive function;cohort;Cohort Studies;Communication;comorbidity;Consumption;CXCR3 gene;cytokine;Demyelinations;Dermatologic;Detection;Development;Diagnosis;diagnostic criteria;Diet;dimer;Early Diagnosis;Etiology;Excision;Exhibits;Exposure to;Female;Food;food allergen;Food Aversion;food consumption;Food Hypersensitivity;gastrointestinal;Genetic;Goals;Human;Hypersensitivity;Hypertrophy;IgE;Immune;Immune response;Immune System Diseases;Immunologic Stimulation;Individual;individual variation;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Ingestion;inhibitor;Integrin alpha4beta1;intestinal barrier;Intestinal permeability;Intestines;Knowledge;Leucocytic infiltrate;Leukocyte Trafficking Inhibition;Leukocytes;Link;male;mast cell;Mediating;Mental Depression;Mental Health;migration;Milk Hypersensitivity;Mobility decline;Moods;Motor;mouse model;Multiple Sclerosis;Mus;Myelin;neural;Neurodegenerative Disorders;neuroinflammation;neuropathology;neuropsychiatric disorder;oligodendrocyte progenitor;Oligodendroglia;Outcome Study;Pathologic;Peripheral;Permeability;pharmacologic;Plasma;Play;prevent;Proteins;PTPRC gene;Reaction;Regimen;remyelination;Reporting;respiratory;response;Risk Factors;Rodent;Role;Sensory;Serum;Stains;stem cells;Surface;Symptoms;Tail Suspension;Testing;Tight Junctions;Tolonium chloride;United States;Whey Protein;zonulin

PROJECT_TITLE: The role of peripheral immune cell activity in food-allergy-induced neuroinflammation and demyelination

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PI_NAMEs: MORGANTE, FABIO  (contact)

PROJECT_TERMS: Accounting;African American;Agriculture;Architecture;Bayesian Method;Big Data;biobank;Blood Pressure;Cardiovascular Diseases;Cause of Death;Centers of Research Excellence;Chromosome Mapping;Clinical;Complex;Computing Methodologies;Data;Data Set;Disease;disorder risk;epigenomics;Equity;Ethics;European;European ancestry;Exposure to;Funding;Genes;Genetic;genetic analysis;genetic architecture;Genetic Drift;Genetic Heterogeneity;genetic variant;genome wide association study;genome-wide;genomic predictors;Genomics;Genotype;Goals;Heritability;Heterogeneity;Human;human data;human disease;Human Genetics;improved;Individual;insight;interest;Knowledge;large datasets;Maps;Medical;Methodology;Methods;Modeling;Modernization;novel;personalized medicine;Phenotype;Play;Population;Population Heterogeneity;precision medicine;predictive modeling;Reporting;Research;Risk Factors;risk prediction;Role;Sample Size;Sampling;sex;Source;Statistical Methods;Statistical Models;Structure;Training;trait;Trans-Omics for Precision Medicine;Variant

PROJECT_TITLE: Genomic Prediction of HumanDisease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PI_NAMEs: ASARNOW, JOAN ROSENBAUM (contact)

PROJECT_TERMS: adaptive intervention;Adolescence;Adverse event;Affect;Algorithms;anxiety treatment;Area;Attitude;Behavior;Caring;Categories;Cause of Death;Cessation of life;Clinical;clinical care;college;community college;Data;Data Science;Detection;digital intervention;Discrimination;Disparity;Dose;early life adversity;Effectiveness;effectiveness evaluation;Emergency department visit;emerging adult;Enhancement Technology;Ethnic Origin;Event;evidence base;Exposure to;Family;Feeling suicidal;Financial Hardship;Food;Friends;Goals;group intervention;Health Status;high risk;Hospitalization;Housing;ideation;improved;indexing;Individual;Intervention;intervention effect;Knowledge;Latinx;Lead;Life Stress;Los Angeles;Low income;Mediating;Medical;Mental Depression;Mental Health;Methods;mobile computing;Modeling;non-suicidal self injury;Outcome;Phase;Population;prediction algorithm;predictive modeling;Prevention;preventive intervention;primary outcome;prognostic algorithm;prognostic model;protective factors;Protocols documentation;prototype;Race;Randomized;rapid detection;reducing suicide;Research;Risk;Risk Factors;Risk Management;risk prediction;Safety;Sampling;Science;screening;secondary outcome;Security;Self-Injurious Behavior;Series;Services;Severities;Site;skills;social determinants;Social support;standard of care;Stress;Student Selections;Students;substance use;suicidal;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Symptoms;Testing;Theoretical model;Time;treatment center;treatment response;Triage;Underrepresented Minority;United States;Update;Work;young adult

PROJECT_TITLE: Project 3


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Hematology;Hodgkin's Disease;Lymphatic Research;Lymphoma;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative: Despite therapeutic advances in Hodgkin Lymphoma (HL), adverse effects of treatment can manifest as early as within one year after treatment and result in considerable morbidity, altered health-related quality of life, and excess mortality. Through an unprecedented, worldwide collaboration of adult oncology HL experts, epidemiologists, statisticians, imaging experts, and decision scientists, we have harmonized modern, multi- source HL data from seminal, international clinical trials and prominent HL registries that will be harnessed via simulation models for translation to clinical use. Our three-step approach (predictive modeling to multi-state modeling to simulation/decision modeling) will be designed to incorporate future prospective data as new/novel treatments and knowledge emerges over time and this project’s results will be significant as they will delineate acute & post-acute outcomes for individual HL patients and inform development of models & paradigms for other diseases.

PI_NAMEs: EVENS, ANDREW M;PARSONS, SUSAN KENYON (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acute;Adult;Adult Hodgkin's Lymphoma;Advocate;Aftercare;Age;Algorithms;alternative treatment;Australia;Biological;Biology;British Columbia;Calibration;Cancer Patient;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Characteristics;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical decision-making;clinical predictive model;Clinical Treatment;Clinical Trials;Clinical Trials Cooperative Group;cohort;Collaborations;Consensus;cost;Cox Proportional Hazards Models;Data;Data Analytics;data dictionary;data modeling;data repository;Data Science;Databases;Decision Making;Decision Modeling;design;Development;Diagnosis;Disease;Disease Outcome;Disease Progression;disorder control;disorder risk;disorder subtype;Dose;Epidemiologist;Europe;Excess Mortality;follow-up;Future;German population;Goals;health care service utilization;health related quality of life;Heart;Hodgkin Disease;Hospitals;Image;Image Enhancement;Immunooncology;improved outcome;Individual;individual patient;innovation;Insurance Claim Review;interest;International;Iowa;Knowledge;Late Effects;Life;Life Cycle Stages;Life Expectancy;Link;Literature;Long-Term Survivors;Malignant Neoplasms;Measures;Methods;Modeling;models and simulation;Modernization;Morbidity - disease rate;mortality;multidisciplinary;neoplasm registry;New Agents;Newly Diagnosed;novel;novel therapeutics;Oncology;open source;optimal treatments;Outcome;Parameter Estimation;Patient Care;Patient risk;Patients;Phase III Clinical Trials;point of care;Population-Based Registry;Positron-Emission Tomography;predictive modeling;Premature Mortality;Preparation;Probability;Progression-Free Survivals;prospective;Quality-Adjusted Life Years;Radiation;Registries;Relapse;response;Rest;Risk Factors;Salvage Therapy;Scientist;Seminal;simulation;Source;Standardization;Statistical Models;success;Survivors;survivorship;Therapeutic;therapy adverse effect;Time;Toxic effect;translational model;treatment effect;Treatment Factor;Visualization

PROJECT_TITLE: Modeling Multi-Source Data in Hodgkin Lymphoma

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Integrase strand-transfer inhibitor (INSTIs) are the mainstay of antiretroviral treatment for people with HIV, but a major side effect is weight gain, which may potentiate the already increased risk for diabetes and cardiovascular disease in an aging HIV population. This proposal addresses key knowledge gaps of INSTI- associated weight gain, including sex-specific patterns and predictors, long-term cardiometabolic consequences, and underlying mechanisms by leveraging the MACS/WIHS Combined Cohort Study, the largest and longest longitudinal interval cohort of men and women living with and at-risk for HIV in the U.S.

PI_NAMEs: ALVAREZ, JESSICA ALEJANDRA;LAHIRI, CECILE DELILLE (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adiponectin;Aging;antiretroviral therapy;Area;Atherosclerosis;Benefits and Risks;bioinformatics tool;Biological Markers;Biological Specimen Banks;Blood Pressure;Blood Vessels;Body fat;Body Weight;Body Weight Changes;Branched-Chain Amino Acids;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Categories;Clinical;clinical data repository;clinically significant;cohort;Cohort Studies;Communities;Data;Detection;Diabetes Mellitus;diabetes risk;Diastolic blood pressure;disorder risk;Energy Metabolism;Enrollment;Epidemic;Exhibits;experience;Fasting;Fatty acid glycerol esters;follow-up;Future;General Population;Glycosylated hemoglobin A;Guidelines;Health;high risk;HIV;HIV/AIDS;Hypertension;Individual;individualized medicine;Inflammation;Inflammatory;inhibitor;inhibitor therapy;insight;Insulin Resistance;insulin signaling;Integrase;Knowledge;Link;Lipids;Measures;men;Metabolic;Metabolic Pathway;metabolome;metabolomics;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Nucleosides;Obesity;Outcome;Pathway Analysis;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Plasma;Population;preemptive intervention;psychosocial;Publishing;Research;Resolution;Reverse Transcriptase Inhibitors;Risk;Risk Marker;Sampling;Selection for Treatments;Serum;sex;side effect;sociodemographics;Tenofovir;Time;treatment guidelines;treatment strategy;United States Dept. of Health and Human Services;Viral;waist circumference;Weight;Weight Gain;Woman;women versus men;Women's Interagency HIV Study

PROJECT_TITLE: SPPACE INSTI Study:  Sex-specific Predictors, Pathways, And Cardiometabolic Effects of Weight Gain Associated with Integrase Strand-Transfer Inhibitors

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Digestive Diseases;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The enteric nervous system is the largest collection of peripheral neurons that function independently of the central nervous system and are critical for controlling key intestinal functions, including motility, nutrient handling, and immune regulation, which have been shown to be dysregulated in the context of inflammatory bowel disease (IBD), irritable bowel disorder (IBS), colon cancer, or during enteric infection. Therefore, a deeper understanding of the mechanisms by which the intestinal immune cells impact the function of enteric neurons is essential for elucidating the link between these two systems. This proposal will investigate the mechanism by which intestinal innate lymphoid promote ENS homeostasis during states of health and disease.

PI_NAMEs: ZHOU, JORDAN ZHENG (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;Address;Birth;Bone Morphogenetic Proteins;Brain;Cells;Central Nervous System;Collection;Colon Carcinoma;Communication;Complex;cytokine;Data;Data Set;density;Development;Disease;Endowment;Enteral;enteric infection;Enteric Nervous System;Feedback;Gastrointestinal Diseases;Gastrointestinal Transit;gene product;Genes;Goals;Growth Factor;gut inflammation;Health;Hematopoietic;Homeostasis;Human;Immune;Immune system;Immune Tolerance;Immunity;immunoregulation;in vivo;Inflammation;Inflammatory Bowel Diseases;interleukin-22;Interleukins;Intestines;Irritable Bowel Syndrome;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;Link;Literature;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphoid Tissue;Macrophage;Malignant neoplasm of gastrointestinal tract;Mediating;microbiota;Modeling;Molecular;Motility;mouse model;Mucous Membrane;Mus;Myenteric Plexus;nervous system development;Nervous System Physiology;Neural Pathways;Neuroglia;Neuroimmune;neuron development;Neuronal Differentiation;Neurons;Neuropeptides;neurotrophic factor;novel;Nutrient;nutrient absorption;pathogenic microbe;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Peristalsis;Population;Production;proto-oncogene protein c-ret;receptor;Regulation;Research Personnel;response;Role;Sampling;Science;Signal Transduction;single-cell RNA sequencing;Stimulus;System;Therapeutic;Time;Tissues;training opportunity;transcription factor;Translating;Vasoactive Intestinal Peptide

PROJECT_TITLE: Regulation of Enteric Nervous System Function by Group 3 Innate Lymphoid Cells


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Urologic Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Urinary catheterization is one of the most common healthcare-related procedures; however, placement of a catheter is known to predispose patients to the development of catheter-associated urinary tract infections. Bladder inflammation is induced upon catheterization and changing the bladder environment allowing a diverse group of pathogens to infect. Fibrinogen, a proinflammatory protein, is released in the bladder and deposited onto the catheter surface, becoming a key platform for microbial colonization. This project focuses on understanding how modulation of protein deposition on the catheter by using a liquid surface coating may affect microbial colonization, biofilm formation, and systemic dissemination, as well as the inflammation response. This approach will offer new insights to inform the development of new clinical treatments that will continue to remain effective long-term.

PI_NAMEs: FLORES-MIRELES, ANA LIDIA (contact);HOWELL, CAITLIN L

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Accounting;Acinetobacter;Adhesions;Affect;aging population;alternative treatment;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Bacteremia;Bacteria;Binding;Binding Proteins;biomaterial interface;Biomedical Engineering;Bladder;Candida;Candida albicans;catheter associated UTI;Catheterization;Catheters;Cessation of life;Chronic;Clinical;Clinical Treatment;Clinical Trials;Collaborations;cytokine;Data;Deposition;design;Development;Devices;Disease;Disease Progression;drug resistant pathogen;Edema;Elements;Enterococcus;Enterococcus faecalis;Environment;epithelial wound;Escherichia coli;Exhibits;experimental study;Fibrinogen;Frequencies;Functional disorder;Goals;healing;Health;Health care facility;Healthcare;healthcare-associated infections;Histologic;Host Defense;Hour;Human;Immobilization;immune cell infiltrate;Immune response;Immune system;Immunologics;Implant;improved;In Vitro;in vitro testing;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Klebsiella pneumoniae;Knowledge;Life Style;Liquid substance;Mechanical Stress;Mechanics;Medical;Medical Device;methicillin resistant Staphylococcus aureus;microbial;Microbial Biofilms;microbial colonization;microbial host;Modernization;Modification;mouse model;Mus;Nosocomial Infections;novel;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathologic;Patients;Persons;Plants;Positioning Attribute;Predisposition;prevent;Procedures;Process;Proteins;Proteomics;Proteus mirabilis;Pseudomonas aeruginosa;Publishing;Quality of life;Recommendation;Research;Resistance;response;Role;Silicones;Silver;Staphylococcus aureus;Surface;surface coating;Systemic infection;Testing;Thinness;Tissues;urinary;Urinary Catheterization;Urinary tract;Urinary tract infection;Uropathogen;Water;Work

PROJECT_TITLE: Understanding the role of catheter-associated protein deposition in the development of CAUTI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Opioid use disorder is a public health crisis in the United States with roughly 80,000 overdoses taking place in 2021, therefore further studies are needed into the molecular and cellular changes underlying the habitual/compulsive use characteristic of this disorder. Previously, the Hurd Lab identified alterations in Fyn kinase within the dorsal striatum, a region implicated in habitual drug use and craving, as associated with heroin use in humans, which, when reversed, decreased heroin seeking in a translational model of relapse. My project will investigate the impact of Fyn modulation on goal-directed and compulsive heroin self- administration, activity of dorsal striatal neurons during heroin seeking, and gene expression to give me training in behavioral models of compulsive drug seeking, in-vivo fiber-photometry, and RNA-sequencing and bioinformatics.

PI_NAMEs: SHERMAN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;Accounting;addiction;Affect;Animal Model;Autopsy;Behavior;Behavioral;Behavioral Assay;Behavioral Model;Bioinformatics;Biological Assay;Calcium;Cannulas;career;cell type;Cells;Characteristics;Chromatin;Compulsive Behavior;Corpus striatum structure;craving;Cues;Cyclic AMP;density;design;differential expression;Disease;Dorsal;drug craving;drug seeking behavior;Drug usage;Epigenetic Process;epigenome;experience;experimental study;Female;Fiber;Future;Gene Expression;Genes;Genetic Transcription;Glutamates;Goals;Heroin;heroin use;Heroin Users;Human;Image;Implant;in vivo;Individual;Infusion procedures;inhibitor;interest;Intoxication;knock-down;Laboratory Study;large datasets;Lateral;Learning;Long-Evans Rats;male;Measures;Medial;Mediating;Molecular;motivated behavior;Motivation;mRNA Expression;multidisciplinary;negative affect;neural;Neurons;Occupations;Ontology;Operative Surgical Procedures;Opiate Addiction;opioid use disorder;optical fiber;Overdose;overdose death;Pathology;Pathway interactions;Pharmaceutical Preparations;Phase;Phosphotransferases;Photometry;Physicians;Population;postsynaptic;prevent;Promoter Regions;Proto-Oncogene Proteins c-fyn;Public Health;Rattus;Relapse;response;Rewards;Role;Sampling;Scientist;screening;Self Administration;Signal Transduction;Small Interfering RNA;small molecule;Substance Use Disorder;Synapses;synaptic function;Synaptic plasticity;Testing;Training;transcription factor;transcriptome sequencing;translational model;United States;Viral;Withdrawal

PROJECT_TITLE: The Role of Fyn Kinase in the Dorsal Striatum in Heroin Use Disorder


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: ANHOLT, ROBERT R. H;DUREN, ZHANA  (contact)

PROJECT_TERMS: Affect;Benchmarking;cell type;Cells;Centers of Research Excellence;Chromatin;comparative;Computer software;Computing Methodologies;Data;Data Analyses;Data Set;Databases;Development;Disease;Elements;Environment;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic variant;Genome;genomic data;Goals;Human Genetics;interest;Location;Methods;Multiomic Data;Patients;Phenotype;Pilot Projects;Publishing;Regulatory Element;Resolution;Sampling;single cell analysis;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Statistical Methods;Technology;transcription factor;transcriptomics;Untranslated RNA;Work

PROJECT_TITLE: Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics Data


ORG_CITY: RICHMOND

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Current therapeutic approaches have generally proven ineffective in treating patients with advanced prostate cancer (CaP) that has metastasized to bone. Understanding the mechanisms contributing to CaP progression, involving the tumor cell and its microenvironment, and developing improved therapeutic strategies to eradicate bone metastases is crucial for diminishing disease morbidity and mortality. Using clinically effective immunotherapy in combination with molecular-targeted therapies may provide a safe and effective treatment to achieve this goal.

PI_NAMEs: FISHER, PAUL B (contact);WANG, XIANG-YANG SHAWN

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Adherence;advanced prostate cancer;Age;Androgens;angiogenesis;Animal Model;anti-cancer;anti-cancer research;anti-cancer therapeutic;antiangiogenesis therapy;anticancer activity;Antigens;Autophagocytosis;bone;Bone Marrow Cells;cancer cell;cancer diagnosis;Cancer Etiology;carcinogenesis;Cell Communication;Cellular immunotherapy;Cessation of life;Clinic;Clinical;combinatorial;Complication;Comprehension;conventional therapy;curative treatments;cytokine;Data;Development;Diagnosis;Disease;effective therapy;efficacy evaluation;engineered T cells;Engineering;Environment;Genes;Goals;Hormones;Human;Immune;immune checkpoint blockade;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Induction of Apoptosis;inhibitor;innovative technologies;insight;Insulin-Like Growth-Factor-Binding Proteins;Interleukin-24;Invaded;Lesion;male;Malignant Bone Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma differentiation associated gene-9;men;Metastatic Neoplasm to the Bone;metastatic process;Metastatic Prostate Cancer;Modality;Modeling;Molecular;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Neoplasm Metastasis;neoplastic cell;next generation;novel;novel therapeutics;Organ;Pathogenicity;Patients;pharmacologic;Phenotype;Positioning Attribute;pre-clinical;Pre-Clinical Model;Procedures;Process;programs;promoter;Property;prostate cancer cell;prostate cancer metastasis;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Proteins;rational design;Reagent;receptor;relapse prevention;Research;Research Proposals;Role;Scheme;Signal Transduction;Site;skeletal;small molecule;small molecule inhibitor;Solid;STAT3 gene;subtraction hybridization;success;synergism;T cell therapy;T-Cell Immunologic Specificity;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Toxic effect;Translating;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Interplay between tumor and microenvironment in bone metastasis

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Despite unquestionable past successes in medicine, most complex terpene natural products have yet to realize their full potential as therapeutic agents. This program will greatly expand the chemical toolkit of small molecules for the treatment and understanding of human disease using natural product structures as inspiration. During the course of this work, new synthetic strategies, methods, chemical reactivity principles, and natural product mechanisms of action will be uncovered and developed.

PI_NAMEs: MAIMONE, THOMAS JOHN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthesis of Complex Terpenes From Simple Precursors: Renewal

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Epstein-Barr Virus (EBV) associated malignancies remain to be a significant threat to human health. These studies will elucidate the molecular basis through which EBV super-enhancers activate oncogenic drivers to immortalize normal B lymphocytes into lymphoblasts and identify potential targets for intervention.

PI_NAMEs: ZHAO, BO  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Affect;AIDS-Related Lymphoma;Autoimmune Diseases;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Biological Models;Bromodomain;Carcinoma;Cell Line;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;CRISPR screen;CSPG6 gene;deep sequencing;Development;Disease;DNA;DNA Binding;DNA Methylation;EBV-associated disease;Elements;Enhancers;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus Nuclear Antigens;Epstein-Barr Virus-Related Malignant Neoplasm;experimental study;Gene Expression;Genes;genetic manipulation;Genetic Transcription;genome-wide;Growth;Health;HIV;Human;Human Herpesvirus 4;Immune;Immunoprecipitation;In Vitro;Infectious Mononucleosis;inhibitor;insight;Intervention;knock-down;Knock-out;Link;lymphoblast;lymphoblastoid cell line;Lymphoma;Lymphoproliferative Disorders;Malignant Neoplasms;Membrane Proteins;Modeling;Molecular;myocyte-specific enhancer-binding-factor 2C;NF-kappa B;novel therapeutics;Oncogenes;Oncogenic;Oncoproteins;Persons;post-transplant;programs;Proliferating;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Reporter;Rest;Rheumatoid Arthritis;RNA;Role;RUNX3 gene;Signal Transduction;Site;small hairpin RNA;SPI1 gene;Testing;Therapeutic;Therapeutic Intervention;transcription factor;tumorigenesis;Viral Genes;Viral Proteins;young adult

PROJECT_TITLE: Targeting Epstein-Barr Virus Super-Enhancer

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE (revised)  This research is relevant to public health because chronic stress profoundly impacts brain circuit function and is a major risk factor for many neuropsychiatric disorders. In this project the causal role of neural circuits in chronic social stress-induced behavioral impairments in both male and female mice will be studied to provide a mechanistic understanding on social circuit maladaptive changes in response to chronic stress. Successful completion of this study will likely establish a lead neural circuit for targeted interventions to neuropsychiatric diseases featuring social impairments.

PI_NAMEs: FERGUSON, DEVEROUX  (contact);QIU, SHENFENG

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acute;Adopted;Affect;Behavior;behavioral impairment;behavioral outcome;Binding;Bioinformatics;Brain;brain circuitry;Brain region;cell type;Chronic;Chronic stress;Cognitive;combat;cortico-limbic circuits;Data;depressive symptoms;Development;Disabling;Electrophysiology (science);emotional stimulus;Environmental Risk Factor;Etiology;executive function;Exposure to;Female;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic;genetic risk factor;genome wide association study;Glutamates;Goals;Homeostasis;Human;Human Genetics;Immunoprecipitation;Impairment;innovation;Intervention;Investigation;Label;Laboratories;Lasers;Lead;Link;LoxP-flanked allele;male;Maps;Medial;Mediating;Medical;Mental Depression;Mental disorders;Messenger RNA;Modeling;Molecular;Molecular Biology;Morphology;Mus;neural;neural circuit;Neuroanatomy;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;Nucleus Accumbens;Opsin;optogenetics;patch clamp;Pathology;Play;Population;Population Projection;Predisposition;Prefrontal Cortex;prevent;psychiatric symptom;Psychological Stress;Public Health;recruit;Reporter;Research;Research Personnel;resilience;Resistance;response;Ribosomes;RiboTag;Risk Factors;Role;Scanning;selective expression;sex;Shapes;SIRT1 gene;Slice;social;Social Behavior;social defeat;social deficits;social stress;Stress;Stress and Coping;stressor;Synapses;synaptic function;Tamoxifen;Testing;Therapeutic;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;Translating;Viral

PROJECT_TITLE: Prefrontal-Accumbens Neurocircuits Mediating Response to Social Stress

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative: There is widespread consensus that early detection of Alzheimer's using non-invasive biomarkers is critical, because cognitive and memory deficits occur past the point of no return. Full validity and relevance of these biomarkers requires detailed understanding of their underlying biological mechanisms, and how they relate to disease progression. Here we seek to understand the cellular and circuit mechanisms underlying two emerging biomarkers, gap detection and fMRI functional connectivity measures. This understanding will deepen and extend the validity of these biomarkers for early diagnosis of Alzheimer's, could also provide a basis for the development of new therapeutic strategies.

PI_NAMEs: WEHR, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;amyloid pathology;Appearance;Area;Auditory;Auditory area;Auditory system;Behavior;Behavioral;behavioral impairment;Biological;Biological Markers;Brain region;Cell Death;Chronic;Cognitive deficits;Consensus;Data;density;Detection;Development;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;early onset;Electrophysiology (science);Failure;Feedback;Functional impairment;Functional Magnetic Resonance Imaging;Genetic;Goals;hippocampal pyramidal neuron;Image;Impairment;innovation;insight;Investigation;Knowledge;Measures;Memory impairment;Molecular;molecular pathology;Motor;Motor Cortex;mouse model;Mus;Nature;neural;neural circuit;Neurobiology;Neurons;novel;novel therapeutic intervention;operation;Output;potential biomarker;Research;Resolution;Rest;Senile Plaques;Sensory;sensory cortex;Synapses;Testing;Therapeutic Intervention;Time;two-photon

PROJECT_TITLE: Circuit mechanisms underlying network disruption and temporal processing deficits in Alzheimer's


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Despite of a great deal of effort by public and private institutions, we don't have a prophylactic vaccine against HIV-1 or an eradication protocol to treat infected patients. Recently, laboratories all over the word have reported an increase in the transmission of HIV-1 strains that are resistant to one or more components of the antiretroviral (ART) cocktail. In order to find novel therapeutic targets, basic understanding of HIV-1 replication is urgently needed. This proposal will study the basic mechanisms of the early steps of HIV-1 infection, which may lead to the discovery of novel and more effective therapeutic targets for HIV-1/AIDS.!

PI_NAMEs: DIAZ-GRIFFERO, FELIPE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Affect;Anti-Retroviral Agents;Binding;Capsid;Capsid Proteins;CD4 Positive T Lymphocytes;Cell Nucleus;Cells;Complex;Cyclophilin A;Cyclophilins;Cytoplasm;Cytosol;Data;Dissociation;Elements;Event;Funding;Genetic;Genome;HIV;Human;Infection;Infection Control;Institution;Laboratories;Life Cycle Stages;Link;Modeling;monomer;mutant;new therapeutic target;novel;Nuclear;Nuclear Import;Nuclear Pore Complex Proteins;Patients;Pharmaceutical Preparations;pharmacologic;Play;prevent;Preventive vaccine;Privatization;Productivity;Proteins;Protocols documentation;recruit;Reporting;resistant strain;Reverse Transcription;Reverse Transcription Inhibition;Role;Structure;Testing;therapeutic target;therapeutically effective;transmission process;Viral;viral RNA;virus core;Virus Diseases;Virus Replication

PROJECT_TITLE: Modulation of retroviral uncoating by cellular factors


ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Loss of RB function is a dominant mechanism driving prostate cancer lethality. It is therefore critical to identify potential therapeutic strategies targeting this disease mechanism to reduce prostate cancer mortality rates and improve the well-being of patients and their families who are experiencing the impact of the disease. Our work will delineate downstream effectors of the RB/E2F pathway and provide novel insights into the contributions of RB to ferroptosis as well as the preclinical data regarding efficacy, safety, and biomarkers required for the rational design of future clinical trials targeting ferroptosis as a therapeutic approach to treating lethal RB1-deficient prostate cancer.

PI_NAMEs: CHEN, MING  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Affect;androgen independent prostate cancer;Automobile Driving;Biological Assay;Biological Markers;Biological Models;biomarker development;biomarker identification;British Columbia;Cancer Patient;cancer therapy;Castration;Cell Death;Cell Line;Clinic;Clinical;Clinical Trials;Collaborations;Data;Death Rate;design;Disease;DNA Sequence Alteration;drug candidate;Drug Combinations;Epithelium;Event;experience;Family;Foundations;Future;Genetic;Genetically Engineered Mouse;Immunohistochemistry;improved;In Vitro;in vivo;in vivo evaluation;Individual;insight;interdisciplinary approach;Investigation;Iron;Knowledge;Lipid Peroxidation;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;men;Modeling;Molecular;mouse model;Neoplasm Metastasis;Neurosecretory Systems;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Personal Satisfaction;pre-clinical;preclinical study;Preclinical Testing;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer model;rational design;RB1 gene;Research;Resistance;Role;Safety;Sampling;Stains;targeted treatment;Technology;Testing;Therapeutic;therapeutically effective;Translations;tumor;tumor xenograft;Universities;Up-Regulation;Validation;Work;Xenograft Model

PROJECT_TITLE: Targeting Ferroptosis in Lethal RB1 Deficient Prostate Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PI: Sinha, Rajita TITLE: Chronic Alcohol and Brain Stress Circuit Response (R01-AA013892-15) PROJECT NARRATIVE There is a current opioid crisis in the US driven by high levels of chronic pain and heavy alcohol intake that alters brain and peripheral pain and stress pathways in ways that promote increased alcohol craving and heavy drinking risk. This project will study men and women with and without alcohol use disorder (AUD) and those with and without chronic pain in an experiment of neural and biobehavioral responses to stress/pain and alcohol cues relative to neutral cues, and also assess if changing those responses with standard behavioral pain and AUD treatment improves clinical pain and craving symptoms and pain-related alcohol use outcomes in AUD. Findings will critically inform development of new interventions to reduce pain-related heavy drinking to improve alcohol use and pain outcomes.

PI_NAMEs: SINHA, RAJITA  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Address;Adrenal Glands;Age;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol relapse;alcohol use disorder;Alcohols;Amygdaloid structure;Behavior Therapy;Behavioral;biobehavior;Brain;Brain region;Chronic;chronic alcohol ingestion;chronic pain;chronic pain patient;Clinical;clinical pain;Cognitive Therapy;comorbidity;connectome;connectome based predictive modeling;Corpus striatum structure;Counseling;craving;Cues;daily pain;Data;design;Development;disorder risk;drinking;emotional distress;Endocrine;experience;Experimental Designs;experimental study;Fasting;FDA approved;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;gray matter;Handedness;Health Care Costs;Heavy Drinking;Hydrocortisone;Hypothalamic structure;Image;improved;Individual;Insula of Reil;Intervention;Label;Magnetic Resonance Imaging;Magnetism;Measures;men;Methods;Negative Reinforcements;neural;neuroadaptation;Neurosecretory Systems;novel;opioid epidemic;Outcome;Pain;pain outcome;pain reduction;Pathway interactions;Patients;Peripheral;peripheral pain;Pharmaceutical Preparations;Phase;Physiological;Prediction of Response to Therapy;Prefrontal Cortex;Prevalence;prospective;Race;Recording of previous events;Recovery;Regulation;Relapse;relapse risk;Reporting;Research;response;Risk;Sampling;Scanning;sex;societal costs;Stress;Symptoms;therapy development;Time;Trauma;treatment duration;Treatment Failure;treatment risk;Visual;Woman;Work

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative. This proposal seeks to elucidate how the immune system regulates its mechanisms that detect, control and eliminate cancers and virally infected cells. This is an important issue because this process is essential to a patient's ability to prevent and/or fight these diseases naturally or in the setting of immunotherapy. The information gained from the proposed studies may lead to a better ability to predict and/or manipulate immune responses to tumors and ultimately aid in the immunotherapy of cancers.

PI_NAMEs: ROCK, KENNETH L (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abbreviations;Affect;Antigen Presentation;Antigen-Presenting Cells;Atomic Force Microscopy;Binding;Biological;Biological Markers;Cancer Control;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Cessation of life;Clinical;clinical predictors;Clinical Research;clinical translation;cohort;Complex;Cross Presentation;Data;Dendritic Cells;density;Disease;Electron Microscopy;Endoplasmic Reticulum;Exclusion;experimental study;Family member;fighting;Formalin;gain of function;Genetic Screening;Goals;Hemagglutinin;Host Defense;Human;I-antigen;Immune;immune checkpoint blockade;immune clearance;Immune Evasion;Immune response;Immune system;immunogenic;Immunohistochemistry;Immunologic Surveillance;Immunoprecipitation;Immunotherapy;improved;inhibitor;insight;Kinetics;Ligands;loss of function;Major Histocompatibility Complex;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Membrane Microdomains;MHC Class II Genes;Modeling;Molecular;Mus;novel;Outcome;Paraffin Embedding;Pathologic;Patients;Peptide/MHC Complex;Peptides;Physiology;Pre-Clinical Model;preclinical study;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;receptor;Regulation;Renal Cell Carcinoma;Resistance;response;Role;Scanning;Signal Transduction;T cell response;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic target;Time;Transcript;Translating;treatment and outcome;tumor;Tumor Escape;Viral;Virus;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Role of Tspan5 in MHC I antigen presentation and cancer immune evasion

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This research seeks to reduce inappropriate antibiotic use in pediatric acute lower respiratory tract infections, the most common serious infections in childhood. Antibiotic overuse is common in this population and is associated with substantial consequences. The major goals of this proposal are to design, implement, and evaluate the effectiveness of clinical decision support tools that promote judicious use of antibiotics in children and adolescents with lower respiratory tract infections in real-world emergency and inpatient settings.

PI_NAMEs: WILLIAMS, DEREK J. (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Reducing Overuse of Antibiotics with Decision Support: The ROADS Study

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Depression;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Palliative Care;Pediatric;Rehabilitation;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This prospective study will examine the factors that account for variability in the trajectories of well-being and mental health in family caregivers of young adults with autism and other developmental disorders, linking them to biological measures of accelerated aging. Social connectedness, generative activities, cumulative caregiving burden, life events and transitions, family functioning and demographics and young adult characteristics will be evaluated as potential contributors to positive and negative outcomes in family caregivers. This study will inform our understanding of the types of supports needed for caregivers of aging individuals with autism and other developmental disorders.

PI_NAMEs: LORD, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Adult Children;adult with autism spectrum disorder;Affect;Age;age acceleration;Aggressive behavior;Aging;Anxiety;autism spectrum disorder;autistic;autistic children;Behavior;Behavioral;Belief;Biological;Biological Aging;Biological Process;Buffers;care giving burden;Caregiver Burden;caregiver education;caregiver stress;Caregiver well-being;Caregivers;caregiving;Caring;Characteristics;Child;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive function;coping;Coping Skills;Data;Deceleration;Dementia;demographics;depressive symptoms;Development;Developmental Delay Disorders;Developmental Disabilities;developmental disease;diaries;Disease;Education;Event;Exposure to;externalizing behavior;Family;Family Caregiver;Financial Support;Future;Goals;Health;Home;improved;Income;Independent Living;individuals with autism spectrum disorder;Interview;late life;Life;Link;Longitudinal Studies;longitudinal, prospective study;Measures;Mental Depression;Mental Health;Modeling;older adult;Outcome;Patient Self-Report;Personal Satisfaction;Physical Function;Predictive Factor;prevent;promote resilience;prospective;Prospective Studies;Questionnaires;Race;Recording of previous events;Research;resilience;Resources;Retirement;Risk;Role;Sampling;social;social factors;Social Network;Social support;Specificity;Stress;Testing;Time;verbal;Work;young adult;young adult with autism spectrum disorder

PROJECT_TITLE: Family caregivers in later life: A longitudinal study of well-being and mental health in families of adults with autism and developmental disabilities

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Successful completion of the experiments listed in this proposal will characterize, in detail, the Clostridium difficile spore ‘germinosome’ complex – a complex consisting of the CspB, CspA, CspC and SleC proteins – and how this complex is formed. Moreover, this application will identify and characterize YabG protease substrates (other than CspBA and preproSleC). The knowledge gained from these experiments could lead to the design of novel therapeutics to combat C. difficile spore germination.

PI_NAMEs: SORG, JOE  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Air;Alleles;Amino Acids;Anaerobic Bacteria;Antibiotic Resistance;antibiotic-associated diarrhea;Antibiotics;Appearance;Bacillus subtilis;Bacteria;Bile Acids;Binding;Biological Assay;candidate validation;Cell Wall;Cells;Chenodeoxycholic Acid;Clostridium difficile;combat;Complex;cost;cost estimate;Data;design;Disease;Dissociation;Dryness;endolysin;Endospore-Forming Bacteria;Environment;Epidemic;Excretory function;experimental study;Exposure to;Gastrointestinal tract structure;Genes;Genetic Screening;Germ Cells;Germination;Glycine;Growth;health care settings;Healthcare Systems;Hospitals;hybrid protein;Immunocompromised Host;Immunoprecipitation;Incubated;Infection;inhibitor;Knowledge;LytA enzyme;Mediating;Membrane;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mothers;mouse model;Mutagenesis;mutant;Mutate;novel;novel therapeutics;Organism;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Phase;Phenotype;Process;Production;protein purification;Protein Secretion;Proteins;Reaction;receptor;Recombinants;Reporting;Reproduction spores;Research Personnel;Risk;Role;Signal Transduction;Signaling Protein;Site;Surface;Symptoms;Taurocholic Acid;Testing;Toxin;United States;validation studies;Work

PROJECT_TITLE: Mechanisms of Clostridium difficile spore germination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(02)M]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: OLD WESTBURY

ORG_NAME: NEW YORK INST OF TECHNOLOGY

PHR: Project Narrative: The manifestation of depressive symptoms is contributed by the disturbance of complex neural networks, including the dopaminergic neural circuit. Astrocytes have been shown to play an important role in the modulation of neuronal activity and synaptic plasticity, and may be crucial for dopamine release during the development and progression of depressive symptoms. The proposed research aims to understand the mechanisms and contribution of insulin signaling-dependent exocytosis of ATP by astrocytes on the regulation of dopamine signaling and reward deficits under chronic stress exposure, which will further expand our understanding of the etiology of depressive disorders and may reveal new therapeutic approaches for depressive disorders.

PI_NAMEs: CAI, WEIKANG  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Affect;Astrocytes;Autopsy;Beds;Behavior;Behavioral;behavioral outcome;Biological Assay;Brain;Chronic;Chronic stress;Cognition;Complex;Control Groups;Crowding;Data;density;Depressive disorder;depressive symptoms;Development;Diabetes Mellitus;Dopamine;dopamine system;Eating;Electrophysiology (science);Emotions;Epidemiology;Etiology;Exocytosis;Exposure to;gamma-Aminobutyric Acid;Gene Silencing;Genetic;Glutamates;Homeostasis;Hormones;House mice;Housing;Image;Impairment;In Vitro;in vivo;Individual;inhibitor;Injections;insight;Insulin;insulin signaling;Light;Link;Luciferases;Lysosomes;Major Depressive Disorder;Measures;Medial;Mediating;Mental Depression;Mental disorders;Metabolic;Microdialysis;Molecular;monoamine;Moods;Morphology;mortality;Motivation;mouse model;Mus;Mutation;neural circuit;neural network;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;Noise;Norepinephrine;novel;novel therapeutic intervention;Nucleotides;Nucleus Accumbens;Nutrient;overexpression;Pathogenesis;Pathway interactions;Persons;pharmacologic;Physical activity;Play;Prefrontal Cortex;presynaptic;putamen;Regulation;Research;reward processing;Rewards;risk variant;Role;Route;selective expression;Serine;Serotonin;severe mental illness;signal processing;Signal Transduction;Signaling Molecule;Site;Sleep;social defeat;Stress;Stressful Event;stressor;Sucrose;Synaptic plasticity;Testing;trafficking;Tyrosine Phosphorylation;ultra high resolution;Viral;Virus

PROJECT_TITLE: Astrocyte-derived signals for neuronal and behavioral modulation and its implications in mental illness.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This project is relevant to public health, as it will foster a better understanding of the relative influences psychological, social, and epigenomic factors have on cLBP and will also give insight into the mechanism the drives racial disparities in cLBP. The proposed project is in response to NIAMS RFA-AR-20-001, Mechanistic Ancillary Studies to Ongoing Clinical Projects. This work lays the foundation for a long-term program of research in developing targeted interventions to reduce cLBP disability and improve outcomes for racial minorities.

PI_NAMEs: AROKE, EDWIN NGOMUEH (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adult;Affect;African American;age acceleration;Ancillary Study;biomarker development;bisulfite sequencing;Black Populations;Black race;Blood specimen;bone;Brain-Derived Neurotrophic Factor;calcification;Caucasians;Chronic;Chronic low back pain;chronic pain;chronic painful condition;Clinical;Collagen;cost;Cysteine;Data;Development;disability;Disability outcome;Disabling;Discrimination;Disparity;DNA;DNA Methylation;DNA Sequence;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;experience;Fibromyalgia;Fostering;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic;Heritability;Hypermethylation;IFNGR2 gene;IL17C gene;Immune Response Genes;improved outcome;Individual;Inflammation;innovation;insight;Interleukin-10;Intervention;Intervention Studies;intervertebral disk degeneration;Knowledge;Literature;Low Back Pain;low socioeconomic status;Measures;Mental Depression;Methylation;methylation pattern;Molecular;Moods;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;NFKB2 gene;novel;NR3C2 gene;Opioid Receptor;Pain;Pain Free;pain outcome;Parents;Participant;Patients;peripheral blood;Persons;Pilot Projects;Postoperative Pain;Productivity;programs;Promoter Regions;prospective;Protein Secretion;Proteins;psychologic;psychosocial;Public Health;Quality of life;Race;racial difference;racial discrimination;racial disparity;racial diversity;racial minority;racial population;receptor expression;Research;response;RUNX1 gene;Sampling;Severities;social;social stigma;Socioeconomic Status;Spinal Fusion;Stress;Stressful Event;Technology;Tissue-Specific Gene Expression;TNF gene;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back Pain


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative Retinitis pigmentosa is a group of blinding diseases and is the most common cause of inherited retinal diseases causing vision loss. Modern retinal imaging methods can non- invasively measure the progression of these disorders. The proposed project is important to public health because we will accurately quantify biomarkers of disease on retinal images to determine whether a novel treatment, N-acetyl cysteine, can significantly slow the progression of this devastating condition, which would thereby reduce personal, financial, social, and health burden costs.

PI_NAMEs: FARSIU, SINA ;JAFFE, GLENN  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Acetylcysteine;adaptive optics;Archives;Area;Biological Markers;Blindness;Certification;Characteristics;Clinical;clinical research site;Clinical Trials;Collaborations;comparison control;Computer software;cost;Custom;Cysteine;Data;data exchange;data submission;Databases;deep learning algorithm;design;Disease;Disease Progression;electronic data;Electronics;Ensure;Eye;Goals;Group Meetings;Health;Human Resources;Image;imaging modality;Infrastructure;Inherited;Length;Manuals;Measures;Methods;Modernization;novel;Optical Coherence Tomography;Phase;Photoreceptors;Placebos;Process;programs;Protocols documentation;Public Health;Publications;Quality Control;randomized placebo controlled trial;Reader;Reading;recruit;Reproducibility;Research Personnel;Resources;Retina;Retinal Diseases;retinal imaging;Retinitis Pigmentosa;Scanning;Secure;Site;social;software development;software systems;Software Validation;Standardization;System;Testing;Time;time use;Training;transmission process;web platform;Width

PROJECT_TITLE: NAC Attack, a phase-3, multicenter, randomized, placebo-controlled trial with retinitis pigmentosa: OCT Reading Center


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Tuberculosis kills nearly 2 million people annually. Tuberculosis therapy takes 6-9 months, a problem that leads to decreased compliance for taking antibiotics and increased chances of developing drug-resistance. The rise of extensively drug resistant (XDR) strains of M. tuberculosis is a public concern, thus the identification of specific pathways in Mycobacterium tuberculosis that could be targeted by new drugs is of great interest.

PI_NAMEs: DARWIN, KATERINA HERAN (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Animals;Antibiotics;ATP phosphohydrolase;Bacillus;Bacterial Proteins;Biochemical;Cells;chaperonin;combat;Complex;Data;deamidation;Defect;drug resistance development;enzyme activity;Enzymes;Escherichia coli;extensive drug resistance;extracellular;factor A;Funding;Gene Expression;Genes;Genus Mycobacterium;Glutamates;Glutamine;Growth;Heat-Shock Response;in vitro activity;in vivo;Infection;insight;interest;Knowledge;Learning;Life;Link;Lysine;Macromolecular Complexes;Modeling;multicatalytic endopeptidase complex;Mus;mutant;mycobacterial;Mycobacterium tuberculosis;new therapeutic target;Nitrates;novel therapeutics;Organism;paralogous gene;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Persons;Phosphorylation;Physiology;Post-Translational Protein Processing;protein degradation;Proteins;Proteolysis;Quality Control;Reaction;receptor;Recycling;Regulation;Regulon;Reporting;Shapes;Signal Transduction;System;targeted treatment;Testing;Translating;Tuberculosis;tuberculosis treatment;Ubiquitin Like Proteins;unfoldase

PROJECT_TITLE: PROTEASOMAL REGULATION AND PROTEIN QUALITY CONTROL IN M. TUBERCULOSIS

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Cancer;Cardiovascular;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Hypertension;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative This project will test a novel intervention (intensive antihypertensive control) to determine if it will decrease osteonecrosis in children with acute lymphoblastic leukemia (ALL), while also identifying biomarkers of osteonecrosis risk. This can reduce a side-effect of therapy causing lifelong disability, a crucial goal because more than 90% of children with ALL will become long-term survivors. Identification of both interventions and biomarkers for osteonecrosis will have broad significance as this side-effect complicates therapy not only of ALL but for other cancers and autoimmune diseases which use glucocorticoids.

PI_NAMEs: KAROL, SETH EVAN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 10 year old;20 year old;Acute Lymphocytic Leukemia;acute toxicity;Address;Adolescent and Young Adult;Adult;Affect;Age;Ambulatory Blood Pressure Monitoring;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;arm;Attenuated;Autoimmune Diseases;Award;Biological Markers;Biology;biomarker identification;Blood;blood pressure control;Blood Vessels;bone;Bone necrosis;career;career development;Cessation of life;chemotherapy;Child;Childhood Acute Lymphocytic Leukemia;Clinic;Clinical;Clinical Investigator;Clinical Trials;Clinical Trials Design;cohort;Combination Drug Therapy;Data;Development;Development Plans;Diagnosis;didactic education;Echocardiography;Elasticity;Endothelium;Enrollment;Evaluation;experience;follow-up;Functional disorder;Future;Genetic study;genetic variant;Glucocorticoids;Glutamates;Goals;Grant;Health;health related quality of life;Height;high risk;Hip region structure;histological specimens;Hodgkin Disease;Human;Hypertension;hypertension control;hypertensive;Impairment;improved;Institution;Intervention;Joints;K-Series Research Career Programs;Knee;Knowledge;Left;Lesion;leukemia;leukemia treatment;Lifelong disability;Link;Long-Term Survivors;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mentorship;Modeling;Modernization;Morbidity - disease rate;mouse model;Mus;Nitric Oxide Synthase;normotensive;novel;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Pain;Patient Outcomes Assessments;patient stratification;Patients;Perfusion;Physical activity;Physiologic pulse;Physiological;Physiology;Plasminogen Activator Inhibitor 1;Population;pre-clinical;pressure;prevent;Prevention;prospective;Quality of life;radiological imaging;Randomized;Randomized, Controlled Trials;receptor;reduce symptoms;Regimen;Regression Analysis;Replacement Arthroplasty;Reporting;Research;Research Personnel;Risk;Risk Factors;Scientist;Severities;sex;side effect;Site;skills;Stratification;Structure;Symptoms;Testing;Time;tool;Toxin;Training;Training Support;Translating;treatment arm;Treatment-related toxicity;trial planning;Validation;Variant;Vascular Diseases;Vasodilator Agents;Vasomotor;Ventricular;von Willebrand Factor;young adult

PROJECT_TITLE: Hypertension Intervention to Reduce Osteonecrosis in Children with Acute Lymphoblastic Leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lung;Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Alzheimer's disease is the most common neurodegenerative disease and its current lack of effective treatment makes determining factors that may modify the disease course of paramount importance. Sleep disruption is one such factor, and obstructive sleep apnea (OSA), the most common clinical form of sleep disruption, is highly prevalent in the aged. The current proposal addresses the longitudinal impact of untreated OSA on both memory and brain tau accumulation as well as the impact of OSA treatment on tau in cerebrospinal fluid.

PI_NAMEs: OSORIO, RICARDO S;VARGA, ANDREW W (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: actigraphy;Acute;Address;Adherence;Affect;Aftercare;Age;aged;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Anatomy;Apnea;apolipoprotein E-4;Arousal;behavior measurement;Blood;Brain;Brain imaging;brain magnetic resonance imaging;Brain Stem;Cerebrospinal Fluid;Chronic;Clinical;Cognitive;cohort;Communities;Consensus;Data;Deterioration;Disease;Disorientation;Drowsiness;Education;effective therapy;Elderly;expectation;follow-up;Genotype;Heart Diseases;Home;Hour;Hypoxia;Impaired cognition;improved;Individual;interest;Long-Term Effects;Lung Diseases;Measures;medial temporal lobe;Medicare;Memory;Memory Loss;memory process;Metabolism;modifiable risk;Monitor;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropsychiatric disorder;Neuropsychological Tests;Obstructive Sleep Apnea;Older Population;Oxygen;Pathologic Processes;Patient Self-Report;Patients;Performance;Persons;Plasma;Polysomnography;positive airway pressure;Positron-Emission Tomography;Prevalence;Process;Regulation;Resolution;Risk;Risk Factors;Role;Senile Plaques;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;spatial memory;Spinal Puncture;Symptoms;tau aggregation;tau Proteins;tau-1;Testing;Time;uptake;vigilance;way finding;Withdrawal

PROJECT_TITLE: Impact of sleep apnea and its treatment on memory and tau accumulation in the brain

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Invasive lobular breast cancer (ILC), which is characterized by the near universal loss of E-cadherin and unique growth pattern, accounts for 10-15% of all breast cancer (up to 40,000 new cases per year) and is understudied in part due to a lack of credentialed models in which to study the disease. Here we propose to comprehensively generate and characterize cell line, organoid, patient-derived xenograft, homograft and genetically engineered rodent models of ILC and compare them to the human disease. We will perform detailed genomic, epigenomic and transcriptomic analyses, phenotypic studies and therapeutic efficacy studies to test which models recapitulate the unique biology of human ILC, thereby credentialing them for future use in the study of ILC.

PI_NAMEs: LEE, ADRIAN V;OESTERREICH, STEFFI  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Advocate;Affect;Bioinformatics;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Cancer Advocacy;Cancer Biology;Cancer cell line;cancer clinical trial;Cell Culture Techniques;Cell Line;Cells;Characteristics;Clinical;Clinical Trials;clinically relevant;cohort;Collaborations;Communities;Credentialing;CRISPR screen;Data;Dependence;Development;Disease;Drug Screening;drug sensitivity;Duct (organ) structure;E-Cadherin;efficacy study;Encyclopedias;Endocrine;epigenomics;Estrogen receptor positive;Future;gastrointestinal;Gastrointestinal tract structure;Generations;Genetic Engineering;Genetically Engineered Mouse;Genomics;Genotype;Goals;Growth;Guidelines;Histologic;Histopathology;homograft;hormone therapy;Human;Human Biology;human disease;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunology;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Infiltration;innovation;Invaded;Isogenic transplantation;Lobular;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;Maps;Medical Oncology;member;model development;Modeling;Molecular;molecular phenotype;Molecular Profiling;mortality;multidisciplinary;Mus;Neoplasm Metastasis;novel;Oncology;Organoids;Ovarian;Ovary;Pathology;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Patients;Pattern;Peritoneum;Phenotype;Quality of life;Recurrence;Reporting;Resistance;Resources;response;Rodent;Rodent Model;Site;targeted treatment;Testing;transcriptomics;translational applications;translational cancer research;Treatment Efficacy;treatment response;tumor growth;urogenital tract;Validation;Voice;Woman;Work;Xenograft procedure

PROJECT_TITLE: Credentialing Models of Invasive Lobular Breast Cancer for Translational Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PUBLIC HEALTH NARRATIVE Congenital cardiac anomalies represent the most common birth defect, affecting nearly 1% of all live births. Despite significant advances in surgical and medical management, these conditions remain a leading cause of death and disability in the newborn period. One significant source of morbidity and mortality arises from complications associated with the use of currently available prosthetic vascular grafts, cardiovascular patches, and replacement heart valves that are frequently required to perform reconstructive procedures. Tissue engineering offers a potential strategy for creating improved biomaterials for use in congenital heart surgery. In this project, we will elucidate the mechanism underlying LYST-mediated TEVG stenosis, the most common graft-related complication and the critical barrier preventing its widespread clinical use.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Affect;Autologous;Automobile Driving;Biocompatible Materials;Blood Vessel Prosthesis;Blood Vessels;Cardiovascular system;Cause of Death;Cell Physiology;cell type;Cells;Child;CHS1 gene;Clinical;Clinical Research;Clinical Trials;Code;Complication;Computer Models;Congenital Abnormality;congenital heart abnormality;Congenital Heart Surgery;cost;critical period;design;Development;disability;Endosomes;Endothelial Cells;extracellular vesicles;functional restoration;genetic regulatory protein;Goals;graft function;Growth;heart valve replacement;Immune;Immune response;immunoregulation;Immunosuppression;Implant;implantation;improved;improved outcome;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Live Birth;Macrophage;man;Mediating;Medical;Messenger RNA;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Newborn Infant;next generation;novel;operation;Operative Surgical Procedures;Paracrine Communication;Postoperative Period;prevent;Procedures;Process;Production;Proteins;Public Health;rational design;Regulator Genes;repaired;Role;Safety;scaffold;Serious Adverse Event;Signal Transduction;Smooth Muscle Myocytes;Source;Stenosis;Surgical complication;System;Tamoxifen;Therapeutic;Tissue Engineering;Tissues;Transgenic Organisms;Tubular formation;Vascular Graft;vascular tissue engineering;Vesicle;Wild Type Mouse

PROJECT_TITLE: Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft Stenosis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Cadmium is an environmentally prevalent toxic metal posing increasing risk to human health worldwide. The proposed studies will take a step to understand the impact of chronic cadmium exposure on membrane transport and consequently on drug disposition and response in the kidney. Findings from the proposed studies are expected to provide mechanistic insights into the regulation of renal transporter proteins and to fill knowledge void of cadmium exposure as a source of broad variation in drug response.

PI_NAMEs: SHU, YAN  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Affect;Anions;Anti-viral Agents;Antineoplastic Agents;apical membrane;basolateral membrane;Biological;Biological Assay;Cadmium;Cardiovascular Diseases;Carrier Proteins;Cations;Cell membrane;Cell model;Cells;Chronic;Cisplatin;Clinical;Cytoplasmic Protein;Diabetes Mellitus;Disease;disease registry;Dose Limiting;drug disposition;Drug toxicity;Drug Transport;Drug usage;Environment;exposed human population;Foundations;Half-Life;Health;Heavy Metals;Human;Human body;Incidence;Individual;inhibitor;insight;Intoxication;Kidney;kidney cell;Knowledge;Malignant Neoplasms;Mediating;Membrane;Metals;Molecular;mouse model;Multidrug Resistance-Associated Proteins;Mus;nephrotoxicity;Organic Anion Transporters;Organic Cation Transporter;Partner in relationship;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pharmacy (field);Poison;pollutant;protein transport;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Publications;Publishing;Regulation;Research;response;Risk;Role;side effect;small molecule;Source;System;Tenofovir;Testing;Tissues;toxic metal;toxicant;Toxin;trafficking;Transmembrane Transport;Tubular formation;United States Environmental Protection Agency;uptake;Variant;Viral

PROJECT_TITLE: Impact of Cadmium Exposure on Transporter Function and Drug Disposition in the Kidney

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Pediatric;Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Underage Drinking

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Our goal is to conduct a large multi-site randomized controlled trial (RCT) of a promising computer-facilitated Screening and clinician Brief Intervention (cSBI) system designed for delivery by pediatric primary care clinicians and aimed at reducing unhealthy alcohol use and related riding/driving safety risk among adolescent patients. Our setting will be the American Academy of Pediatrics' (AAP) Pediatric Research in Office Settings (PROS) national primary care research network, with >600 U.S. primary care practices having participated in recent studies. This trial addresses the evidence gap identified in the latest U.S. Preventive Services Task Force review of alcohol screening and brief counseling interventions among adolescents, and, if shown effective, the cSBI system could be widely disseminated via AAP's existing education, teaching, and advocacy platforms to its 67,000 pediatrician members, thereby greatly increasing the potential for population- level impact of alcohol screening and brief intervention for U.S. adolescents.

PI_NAMEs: HARRIS, SION KIM;SHRIER, LYDIA A. (contact)

PROGRAM_OFFICER_NAME: SHIRLEY, MARIELA

PROJECT_TERMS: 17 year old;Academy;Address;Adolescent;adolescent patient;Adult;Advisory Committees;Advocacy;Age;age group;Alcohol consumption;alcohol misuse;alcohol screening;alcohol screening and brief intervention;alcohol use disorder;Alcohols;American;Area;Automobile Driving;binge drinking;Boston;brief intervention;Caring;Cause of Death;Child;Childhood;Cluster randomized trial;Computers;Contracts;Counseling;design;drinking;driving safety;Drunk driving;Early identification;Early Intervention;Education;Educational process of instructing;effectiveness testing;Eligibility Determination;Family;Feedback;follow-up;Frequencies;Gender;Goals;Health;Healthcare;impaired driving performance;Impairment;improved;individualized feedback;interest;Intervention;intervention effect;Life;Mediator;Medical;member;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;New England;older patient;Parents;participant enrollment;patient screening;Patients;Pediatric Research;pediatrician;Pediatrics;Phase;Pilot Projects;pilot test;Play;Population;Practice based research;practice setting;practice-based research network;Preventive service;Primary Care;primary care clinician;primary care practice;primary outcome;Protocols documentation;psychoeducation;Quasi-experiment;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;response;Risk;Role;Safety;Sampling;Science;screening;screening and brief intervention;Screening Result;Self Administration;Self Efficacy;Severities;Site;sobriety;societal costs;substance use;success;Surveys;System;Testing;Time;Training;Transportation;treatment as usual;Trust;underage drinking reduction;United States Preventative Services Task Force;Vehicle crash;Visit;wellness visit;Work;young adult;Youth

PROJECT_TITLE: Computer-facilitated Screening and Brief Intervention in pediatric primary care to reduce underage drinking: a large multi-site randomized trial

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Burden of Illness;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Hematology;Mental Health;Palliative Care;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite high levels of stress, there are few empirically-supported stress management interventions for caregivers of allogeneic hematopoietic stem cell transplant (HCT) cancer patients, despite research showing that caregiver burden and distress can have an adverse impact on patient health outcomes, including decreased patient survival. Mindfulness-based approaches may be particularly beneficial, given active mechanisms of mindfulness and the unique stressors experienced by this caregiving population. This project will build on pilot data by randomizing participants to one of three treatment conditions: FOCUS, Healthy Living (HL), and Usual Care (UC) to determine whether FOCUS demonstrates efficacy above HL and UC on caregiver burden, patient distress, and patient healthcare utilization.

PI_NAMEs: VINCI, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: acceptability and feasibility;Affect;Aftercare;Age;Allogenic;Anxiety;arm;Attention;attentional control;Biological Markers;cancer care;Cancer Center;Cancer Intervention;Cancer Patient;cancer transplantation;Caregiver Burden;caregiver interventions;Caregiver support;Caregivers;caregiving;Caring;Child Rearing;Clinic Visits;Conflict (Psychology);Continuity of Patient Care;curative treatments;Data;design;diaries;Disease;Dissemination and Implementation;Distress;efficacy evaluation;emotion regulation;Emotional;Emotions;Esthesia;experience;Family Caregiver;follow-up;Gender;Growth;Hair;Health;health care service utilization;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Home;hospital readmission;Hydrocortisone;improved;Income;Investigation;Length;Malignant Neoplasms;Measures;member;Mental Depression;Mental Health;mindfulness;mindfulness intervention;Mindfulness Training;multidisciplinary;negative affect;novel;Outcome;Participant;Patient Self-Report;Patients;Pilot Projects;pilot test;Placebos;Population;post-transplant;Posttraumatic growth;primary outcome;programs;psychosocial;Randomized;Reaction;Reporting;Research;residence;Role;secondary outcome;Self Efficacy;Stress;stress management;stress reduction;stressor;Symptoms;Testing;Thinking;Time;Transplant Recipients;Transplantation;treatment as usual;United States National Institutes of Health;Work

PROJECT_TITLE: Efficacy of a Mindfulness-Based Stress Management Program for Allogeneic HCT Caregivers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Alcohol and methamphetamine use are associated with increased HIV risk among men who have sex with men (MSM) but the precise behaviors most responsible for this elevated risk are not well understood. This study will integrate data from several large cohort studies to parameterize network epidemic models and provide holistic estimate of the effect of these substances on HIV incidence among MSM. Subsequently, we will leverage these models as an experimental laboratory to evaluate the population level impact of substance use and HIV interventions among MSM, utilizing cutting-edge computational tools to identify robust and optimal interventions for HIV elimination.

PI_NAMEs: JANULIS, PATRICK FRANCIS (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adherence;Age;AIDS prevention;Alcohol consumption;alcohol effect;Alcohols;Behavior;Behavioral;Calibration;Characteristics;Cohort Studies;Collaborations;comparative effectiveness trial;Complex;Computer software;computerized tools;condoms;Continuity of Patient Care;cost;Data;data integration;Data Set;Data Sources;Decision Making;Dependence;design;Drug usage;Ensure;Epidemic;Epidemiology;Ethnic Origin;experience;experimental study;flexibility;Funding;Goals;Health;High Performance Computing;high risk population;HIV;HIV Infections;HIV risk;improved;Incidence;Individual;insight;Intervention;Knowledge;laboratory experiment;Length;medication compliance;men who have sex with men;Methamphetamine;methamphetamine use;model development;Modeling;Modification;National Institute of Drug Abuse;Network-based;novel;Observational Study;open source;Pathway Analysis;Pathway interactions;Persons;Population;Population Dynamics;Populations at Risk;Positioning Attribute;prevent;Prevention;protective factors;Race;reduced substance use;Reporting;Research;Research Personnel;Research Priority;Resources;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Services;Sex Behavior;Sexual Partners;sexual risk behavior;simulation;Source;Structure;Subgroup;substance use;success;Surveys;transmission process;Uncertainty;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Leveraging data synthesis to identify optimal and robust strategies for HIV elimination among substance-using MSM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Congenital heart defects are present in 1-2 out of 100 births, and are the leading non-infectious cause of death in the first year of life, yet the initiating instructions for early heart formation are not well understood. We will use analysis of gene expression and chromatin states in single cells of mouse embryos, as well as live imaging of mouse embryos, to understand the mechanisms by which the first heart cells arise in the embryo.

PI_NAMEs: BRUNEAU, BENOIT GAETAN (contact)

PROJECT_TERMS: Adult;Affect;Arrhythmia;ATAC-seq;Behavior;Birds;Birth;Cardiac;cardiogenesis;Cardiomyopathies;Cause of Death;cell motility;Cells;Chromatin;Complex;Congenital Heart Defects;Defect;differentiation in vitro;DNA;Embryo;Embryonic Development;Embryonic Heart;Enhancers;Event;gastrulation;Gene Expression;Gene Expression Profiling;gene regulatory network;Genes;Genetic;Genetic study;Genetic Transcription;Genome;genome-wide;Genomics;Heart;heart cell;Heart Diseases;Human Genetics;human induced pluripotent stem cells;Image;Impairment;in vivo;Individual;Infant Mortality;Instruction;Knock-out;Knowledge;Label;Light;Live Birth;marker transgenes;Mesoderm;microscopic imaging;migration;Modality;Molecular;Morphogenesis;Mouse Embryonic Stem Cells;Mus;mutant;Nature;Organ;Population;Positioning Attribute;precursor cell;Process;progenitor;Recipe;Regulatory Element;Reporter Genes;response;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;Testing;transcription factor;transcriptome;Transgenic Organisms;Tube;Visualization;Zebrafish

PROJECT_TITLE: Early Cardiac Progenitors

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Increasing recognition and diagnosis of opioid use disorder adds additional complexity to management of other chronic medical conditions commonly seen in primary care, leading to high cost and inappropriate utilization of health services; intensive primary care interventions targeting high-risk patients with opioid use disorder may be a potential solution. The proposed project adapts an intensive primary care intervention of multi-disciplinary staff addressing social determinants of health to outreach complex patients with opioid use disorder seen in primary care, and assesses feasibility, acceptability, and preliminary efficacy to improve quality of care for these patients. The results of this project will help community health systems develop scalable interventions for medically complex patients with opioid use disorder to improve health outcomes.

PI_NAMEs: CHAN, BRIAN  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Area;care coordination;care fragmentation;career development;Caring;Case Study;Chronic;Clinical;Clinical Trials Design;Communities;community engagement;Community Health Systems;Complex;Consolidated Framework for Implementation Research;cost;Data;Diagnosis;Discipline of Nursing;Disease;effective intervention;Enrollment;Ensure;evidence base;Evidence based treatment;experience;faculty mentor;Federally Qualified Health Center;Future;Goals;Health;health care service utilization;health service use;Health Services;Health Services Research;Health system;Heroin;high risk;high risk population;hospital utilization;implementation determinants;implementation science;implementation strategy;improved;improved outcome;Intensive Care;interest;Internist;Intervention;intervention refinement;Intervention Trial;K-Series Research Career Programs;Low income;Measures;Medical;medical complication;medication for opioid use disorder;Medicine;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;mortality;multidisciplinary;National Institute of Drug Abuse;novel;opioid use disorder;Outcome;outreach;patient engagement;Patients;Persons;Pharmacy facility;Physicians;pilot test;pilot trial;Population;pragmatic efficacy trial;prescription pain reliever;preventive intervention;Primary Care;primary care patient;primary care setting;Provider;psychosocial;Quality of Care;Randomized;randomized trial;Research;Research Methodology;Research Personnel;Resources;risk stratification;safety net;Scientist;Signal Transduction;Site;social;social health determinants;social stigma;Strategic Planning;substance use;Substance Use Disorder;success;System;Testing;therapy design;Training;treatment choice;Trust;Work

PROJECT_TITLE: Identifying High Utilizing Patients with Opioid Use Disorder to Engage in Primary Care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: Weston

ORG_NAME: LUXMED SYSTEMS, INC.

ORG_STATE: MA

PHR: NARRATIVE Atrial fibrillation is a major health concern and a primary cause of stroke and thromboembolism. Percutaneous cardiac catheter ablation is currently used to treat atrial fibrillation in order to eliminate a lifelong multidrug regimen but its main limitation is high recurrence rate due to poor intra-procedural ablation monitoring and the inability to visualize lesions directly. We propose to develop and commercialize a new generation of percutaneous ablation catheters that enable direct real-time identification of radiofrequency ablation lesions to achieve safer, faster, cheaper, and more reliable atrial fibrillation ablation therapy

PI_NAMEs: AMIRANA, OMAR ;KAY, MATTHEW W.;RANSBURY, TERRY  (contact);SARVAZYAN, NARINE

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Ablation;Algorithms;Animal Model;Animal Testing;Animals;Arrhythmia;Atrial Fibrillation;Australia;Authorization documentation;Cardiac;Cardiac ablation;Caring;Catheters;Chest;clinic ready;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collagen;commercialization;Complex;Contracts;data acquisition;Data Set;design;Detection;Development;Devices;diagnostic algorithm;Documentation;Ensure;experimental study;Family suidae;Feedback;Fiber;Financial Support;first-in-human;Funding;Generations;healing;Health;Heart;Heart Atrium;heart damage;hemodynamics;Hospitals;Human;human study;Image;improved;Indiana;instrument;instrumentation;Knowledge;Lesion;Location;manufacture;Maps;Medical;meetings;Metabolic;Monitor;Morbidity - disease rate;mortality;Movement;Myocardial tissue;NADH;Names;new technology;novel diagnostics;Optics;Output;Percutaneous Catheter Ablation;Performance;Pharmaceutical Preparations;Phase;Physicians;porcine model;pre-clinical;Preparation;Procedures;product development;Pulmonary veins;Quality of life;radio frequency;Radiofrequency Interstitial Ablation;real time monitoring;Recording of previous events;Recurrence;Regimen;Reporting;Resolution;response;Rest;Safety;safety testing;Secure;Series;Site;Small Business Technology Transfer Research;Source;Stroke;Surface;System;Technology;Testing;Therapeutic;Thromboembolism;Time;tissue injury;Tissues;Touch sensation;Ultraviolet Rays;United States National Institutes of Health;Update;UV sensitive;Validation;Veins;Visualization

PROJECT_TITLE: New generation of catheters for treatment of atrial fibrillation


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Targeting ubiquitin and ubiquitin-associated systems has emerged as a rational strategy in the treatment of human diseases ranging from cancer to neurological and neuromuscular disorders. These targeted approaches are fostered by advances in understanding the fundamental mechanisms of these ubiquitin and ubiquitin-associated systems. The proposed research is relevant to public health and NIH mission in that it aims to promote innovative research discoveries and strategies to advance knowledge of ubiquitin-like systems associated with human health.

PI_NAMEs: MAUPIN-FURLOW, JULIE A (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acetylation;Address;analog;Archaea;ATP phosphohydrolase;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Cell Physiology;Cell Survival;Chemoresistance;Complex;Development;Disease;DNA;DNA Repair;Ensure;Enzymes;Fluorescence Microscopy;Fostering;Goals;Haloferax volcanii;Health;Heat Stress;Homeostasis;Human;human disease;Hydrolase;improved;innovation;insight;Knowledge;Ligation;Link;live cell imaging;Lysine;Malignant Neoplasms;Mediating;Metabolism;Methylation;Mission;Modification;molybdenum cofactor;multicatalytic endopeptidase complex;mutant;Nature;Nerve Degeneration;Nervous System Disorder;Neuromuscular Diseases;novel therapeutics;Nutrient;nutrient deprivation;Outcome;Oxidants;oxidation;Parents;Pathway interactions;persulfides;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Process;protein protein interaction;Proteins;Proteolysis;Proteome;Proteomics;proteostasis;Public Health;Regulation;Research;response;Ribonucleases;Ribosomes;RNA;RNA Processing;Role;sound;Stress;Sulfur;System;Techniques;Testing;thioester;Thiosulfate Sulfurtransferase;Transfer RNA;Translating;Translations;Ubiquitin;Ubiquitin Like Proteins;ubiquitin-protein ligase;United States National Institutes of Health;Uridine;Variant;Virus Diseases;Work

PROJECT_TITLE: Dual function ubiquitin-like proteins in post-translational regulation and sulfur mobilization