ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Transfusion is a common lifesaving therapy, but some patients have an immune reaction to transfused blood, making ongoing transfusion increasingly difficult or even impossible. It is currently difficult to predict which patients will have this problem and there are no accepted therapies to prevent it. The proposed studies aim to develop the ability to predict which patients will have an immune reaction and also to understand why they do. Achieving this goal will have the immediate benefit of allowing the modification of current practices to decrease immune reactions in patients likely to have them and also identify targets to allow new therapies to prevent this problem.

PI_NAMEs: ZIMRING, JAMES C. (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Address;Adenosine;ADORA1 gene;ADORA2B gene;Alloantigen;Alloimmunization;antagonist;Antibodies;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Biology;Blood;Blood Group Antigens;Blood Transfusion;Chronic;Clinical;clinical practice;cohort;Collection;cytokine;Data;Databases;design;ecto-nucleotidase;Erythrocyte Transfusion;Erythrocytes;experimental study;gain of function;Gene Expression;Gene Expression Profile;Genetic Determinism;Genetic Polymorphism;genetic risk factor;genetic variant;genome sequencing;Goals;Human;human model;human study;human subject;Immunize;Immunology;immunoreaction;Individual;Inflammation;innate immune pathways;Interferon alpha;Isoantibodies;Life;Link;Methods;Mitochondria;Modeling;Modification;Molecular;Monitor;mouse model;Mus;novel;novel therapeutics;Nucleic Acids;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Population;Pre-Clinical Model;Predisposing Factor;prevent;Production;programs;Purinoceptor;Regulation;Research;Resources;responders and non-responders;response;Reticulocytes;Risk;Risk Factors;Role;Sampling;Sickle Cell Anemia;Signal Induction;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Specimen;Structure;synergism;Systemic Lupus Erythematosus;targeted treatment;Technology;Testing;Therapeutic Intervention;therapeutically effective;therapy development;Time;TLR7 gene;transcriptome;transcriptomics;Transfusion;Translating;translational genomics;translational model;whole genome

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: SHEEHAN, VIVIEN ANDREA (contact)

PROJECT_TERMS: Acute;Adult;African;Aliquot;Alloantigen;Alloimmunization;biobank;Biology;Blood;Blood specimen;Blood Transfusion;Brazil;Caring;Cell Communication;Chronic;Clinical;clinical application;clinical material;clinical phenotype;cohort;Collaborations;Collection;Complication;Consent;Data;Databases;DNA;Electronic Mail;Ensure;Environment;Erythrocyte Transfusion;Erythrocytes;Event;experience;experimental study;Freezing;Gene Expression;Genetic Transcription;genetic variant;genome analysis;genome sequencing;Healthcare;Hemoglobinopathies;hospital care;Hospitals;human study;human subject;Immunize;immunogenicity;Individual;Inflammation;insight;interest;Investigation;Isoantibodies;Label;Laboratories;Leukocytes;Link;meetings;Metadata;Odds Ratio;Participant;participant enrollment;Pathway interactions;Patients;Pediatric Hospitals;pediatric patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Population;Positioning Attribute;programs;prospective;Reporting;Research;Research Personnel;responders and non-responders;Risk;Role;Sampling;Sampling Studies;Sickle Cell Anemia;single-cell RNA sequencing;Site;Source;Telephone;Test Result;Testing;therapeutic development;Therapeutic Intervention;Time;Trans-Omics for Precision Medicine;transcriptome;Transfusion;transfusion medicine;Validation;Variant;Venous blood sampling;whole genome

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion Scientific Core A


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Hematology;Lupus;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Affect;Agonist;Alloantigen;Alloimmunization;antagonist;Antibodies;Antibody Formation;Antibody Response;Antigen-Antibody Complex;Antigens;Antinuclear Antibodies;Autoimmune;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biological;Biological Assay;Biology;Blood Group Antigens;Cell Separation;Chronic;cohort;Complication;Data;Dendritic Cells;Development;Disease;Epitopes;Erythrocyte Transfusion;Erythrocytes;Female of child bearing age;Fetus;Genes;genetic element;genetic predictors;genetic variant;Genetic Variation;genome wide association study;Glycoproteins;Human;Human Genetics;Immunization;In Vitro;in vitro testing;in vivo;insight;Interferon alpha;Interferons;Isoantibodies;Lead;Leukocytes;Life;life-sustaining therapy;Lymphocytosis;Measures;Messenger RNA;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Newborn Infant;novel;novel therapeutics;Nucleic Acids;Organ;Pathology;Patients;Pattern;Persons;Plasma;pre-clinical;prevent;Pristane;Production;prospective;Reaction;response;Reticulocytes;Risk;Risk Factors;Role;Sampling;Sickle Cell Anemia;Signal Transduction;synergism;System;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic Intervention;Time;TLR2 gene;TLR7 gene;Transfusion;Transgenic Mice;Transgenic Organisms;translational approach;Translations;Variant

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion.  Project 1


NIH_SPENDING_CATS: Immunization

PI_NAMEs: LUCKEY, CHANCE MARION JOHN (contact)

PROJECT_TERMS: Address;Adenosine;ADORA1 gene;ADORA2B gene;Allogenic;Alloimmunization;Alternative Therapies;Antibodies;Antibody Formation;Antibody Response;Antigen-Antibody Complex;Antigens;ATP Receptors;Autoantigens;Autoimmunity;Automobile Driving;B-Cell Activation;B-Lymphocytes;Binding;Biological Markers;Cell Physiology;Cell Surface Proteins;Chronic;Circulation;Clinical;Clinical Trials;clinically relevant;Cyclic AMP;Data;Development;ecto-nucleotidase;Endothelial Cells;Engineering;Equilibrium;Erythropoietin;Event;Exposure to;extracellular;Future;gain of function;Genetic Polymorphism;high risk;Human;hydroxyurea;Hypoxia;Immunoglobulin Class Switching;Immunoglobulin G;Immunosuppressive Agents;Infection;Insulin-Dependent Diabetes Mellitus;Isoantibodies;loss of function;Mediating;model design;Molecular;Morbidity - disease rate;mortality;mouse model;Multiple Sclerosis;novel;patient population;patient subsets;Patients;pharmacologic;Phenotype;Plasmablast;Play;polymerization;Polymers;prevent;Production;Publishing;Purinergic P1 Receptors;Purines;Purinoceptor;Research;Resources;responders and non-responders;response;Role;Sickle Cell Anemia;side effect;Signal Pathway;Signal Transduction;small molecule;Source;Structure of germinal center of lymph node;synergism;Testing;theories;therapeutic target;TLR7 gene;Transfusion;transfusion medicine;Vaccination;virtual

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion.  Project 2


NIH_SPENDING_CATS: Hematology;Prevention;Transplantation

PI_NAMEs: HUDSON, KRYSTALYN E (contact)

PROJECT_TERMS: adaptive immune response;Adherence;Adverse effects;Adverse event;Allogenic;Alloimmunization;American;Anemia;Antibodies;Antibody Formation;Antigen-Presenting Cells;Antigens;Autologous;B-Lymphocytes;Blood donor;Blood Group Antigens;Blood Transfusion;CD36 gene;Cells;Circulation;Clinical;clinically significant;Collecting Cell;Consumption;Data;design;differential expression;Erythrocyte Transfusion;Erythrocytes;Erythroid;Erythropoiesis;Event;Exhibits;Future;General Population;Generations;Goals;Hemolytic Anemia;Hemorrhage;high risk;Hospitalization;Human;Immune;Immune response;Immune system;immunogenic;immunogenicity;improved;In Vitro;Innate Immune Response;insight;Integrin alpha4beta1;Isoantibodies;knockout animal;Knowledge;Lesion;Life;Ligands;Measures;Mediating;Methods;Mitochondria;Modality;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Organelles;Pathway interactions;Patient Care;patient population;Patients;Phenotype;Population;Pre-Clinical Model;Pregnancy;premature;prevent;Production;Reaction;Resources;response;Reticulocyte count;Reticulocytes;Reticulocytosis;Risk;Risk Factors;Sampling;screening;Sickle Cell Anemia;Stress;Surface Antigens;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Therapeutic procedure;therapeutic target;therapeutically effective;Transfusion;Transgenic Organisms;Translating;Transplantation;Trauma;Vascular blood supply;Venous blood sampling

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion.  Project 3


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Acute;admixture mapping;African;Alloantigen;Alloimmunization;Antigens;B-Cell Antigen Receptor;Blood Transfusion;Brazil;Cells;Chromosomes;Chronic;Classification;cohort;Complication;Data;Environment;Erythrocyte Transfusion;Erythrocytes;Event;Exposure to;Gene Expression;Genetic;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;genetic variant;genome analysis;genome sequencing;Haplotypes;human study;Immunize;immunogenicity;Immunoglobulin G;Individual;Inflammation;Inflammatory;insight;Isoantibodies;Leukocytes;Medical;Methods;Molecular;Monitor;novel;Odds Ratio;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Population;Predisposing Factor;prospective;Publishing;Reporting;Resources;responders and non-responders;response;Risk;RNA;Role;Sampling;Serology;Services;Sickle Cell Anemia;single-cell RNA sequencing;Testing;therapeutic development;Therapeutic Intervention;Time;Trans-Omics for Precision Medicine;transcriptome;Transfusion;Variant;whole genome

PROJECT_TITLE: Basic and Translational Mechanisms of Alloimmunization to RBC Transfusion.  Project 4


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Congenital Structural Anomalies;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: The outcomes of this study will provide a method to accurately measure body fat in the clinical environment and information on energy expenditure in youth with spina bifida. This population is at a higher risk of obesity then the general population. These findings will provide a method to screen and support prevention and treatment of obesity through the ability to accurately identify the youth’s weight status and to recommend daily caloric needs for this high-risk population.

PI_NAMEs: POLFUSS, MICHELE  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accelerometer;Address;Adult;Age;Age of Onset;age stratification;Algorithms;arm;Behavior;Biolectric Impedance;Body Composition;Body fat;Body Height;Body mass index;Body measure procedure;Body Weight Changes;Calories;Categories;Characteristics;Child;Childhood;Clinic;Clinical;clinical practice;clinical research site;Clinical Sciences;Clinical Trials;comorbidity;cost effective;Cross-Sectional Studies;Data;Dietary intake;Dietary Practices;disability;doubly-labeled water;Economic Burden;Energy Intake;Energy Metabolism;Ensure;Environment;Equation;Equilibrium;Fatty acid glycerol esters;feasibility testing;Frequencies;Funding;Future;General Population;Geographic Locations;Goals;Health;health management;Health Promotion;healthy weight;Height;high risk;high risk population;Individual;Intervention;Knee;Knowledge;Length;Literature;Measurement;Measures;Medical;Methods;Mission;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;nutrition;Obesity;obesity prevention;obesity risk;obesity treatment;Outcome Study;Participant;peer;personalized medicine;Physical activity;Pilot Projects;Population;population health;Prevalence;prevent;Prevention;Productivity;programs;psychologic;Puberty;Recommendation;Reporting;Research;Research Institute;Research Priority;Risk;Sampling;Science;Self Management;Self-Help Devices;sex;Site;Spinal Dysraphism;Testing;total energy expenditure;Translational Research;waist circumference;Walking;Weight;Weight maintenance regimen;Wheelchairs;Youth

PROJECT_TITLE: Body Composition and Energy Expenditure in Youth with Spina Bifida

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Osteoporosis;Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE The long-term goal of this research is to understand bone anabolism, cessation of treatment and fracture repair in the setting of Down Syndrome (DS). These studies will provide important new insights regarding the specific involvement of genes associated with trisomy 21 and the regulation of skeletal homeostasis. The application provides the first ever assessment of fracture repair and the impact of anabolic treatment cessation in DS.

PI_NAMEs: SUVA, LARRY J. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Ablation;Affect;Anabolism;Antibodies;Behavioral;bone;Bone Density;bone fracture repair;bone health;bone loss;Bone Marrow;bone mass;bone repair;Bone Resorption;bone strength;bone turnover;Calcineurin;Cardiovascular system;Cells;Chromosome 21;Clinical;Complex;Craniofacial Abnormalities;Defect;dosage;Down's Syndrome;Down-Regulation;experimental study;FDA approved;Female;Fracture;fracture risk;Gene Expression;Genes;Goals;Homeostasis;Human Characteristics;Human Chromosomes;in vivo;Individual;insight;Intervention;Knockout Mice;Knowledge;Leg;lentivirally transduced;Life Expectancy;Live Birth;Macrophage;male;Modeling;Morbidity - disease rate;mouse model;mouse Ts65Dn;Mus;Neurologic;normal aging;novel;novel therapeutic intervention;osteoblast differentiation;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteocytes;Osteogenesis;Osteopenia;Osteoporosis;overexpression;Pathway interactions;Persons;Phalanx;Pharmacologic Substance;Phase;Phenotype;Physiology;Population;Populations at Risk;pre-clinical;Process;Regulation;Regulator Genes;Research;response;Role;skeletal;Skeleton;Testing;Time;transcriptome sequencing;Transgenic Organisms;Trauma;Trisomy;Video Microscopy;Withholding Treatment;WNT Signaling Pathway

PROJECT_TITLE: Understanding the skeleton in Down Syndrome

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE While emotion dysregulation and sleep disruption are associated with vulnerability for mood disorders during adolescence, the neurodevelopmental underpinnings are unknown. Using a combination of advanced neuroimaging techniques and digital phenotyping, this project will provide critical knowledge on the neurodevelopmental mechanisms linking emotion dysregulation and sleep disruption during adolescence. Such knowledge will yield actionable information regarding the optimal timing of intervention strategies targeting easily modifiable sleep behaviors to improve mental health outcomes, and will thus provide an important contribution to public health. 1

PI_NAMEs: BAGAUTDINOVA, JOELLE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;Age;Amygdaloid structure;awake;Brain;career;Clinical;cognitive development;Data;data resource;Data Set;Development;developmental plasticity;Diagnostic;digital phenotyping;early adolescence;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotions;Epidemiology;fitbit;follow-up;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Human;Image;improved;indexing;Individual;insight;Intervention;Knowledge;large scale data;Link;Location;Machine Learning;Measures;Mediating;Mental Health;Mentorship;Methodology;Mood Disorders;mood symptom;Mus;Nature;neurodevelopment;neuroimaging;Neurons;Neurosciences;next generation;Outcome;Participant;Pathway Analysis;Pennsylvania;Persons;Phenotype;poor sleep;Prevention;programs;prospective;Psychiatry;Public Health;Research;response;Rest;Risk Factors;Role;Sampling;Sleep;sleep behavior;Sleep disturbances;Suicide;Synaptic plasticity;Techniques;Testing;theories;Time;Training;University resources;wearable device;Work;Wrist;Youth

PROJECT_TITLE: The role of sleep in neurodevelopmental plasticity and emotion dysregulation in youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative: Hair cells are responsible for the transduction of sound and acceleration stimuli relevant to the auditory and vestibular sensory systems, respectively. Critically, when the “hairs” or stereocilia of the hair cells are deflected, tip link proteins connecting the stereocilia are pulled upon, opening the mechanoelectrial transduction (MET) ion channels and allowing for excitatory cationic current to enter the hair cells. In this study, recent advances in gene therapy techniques are leveraged to investigate the effects of modulating biophysical properties of the tip link proteins on MET current, which will lead to a better understanding of the basic mechanisms mediating the mechanotransduction function in hair cells.

PI_NAMEs: YEH, FRANK  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acceleration;Acoustic Nerve;Actins;adenovirus mediated delivery;Animal Model;Animals;Apical;Auditory;Auditory system;Binding;Binding Sites;biophysical analysis;biophysical properties;Biophysics;Cadherins;CDH23 gene;Cell Physiology;Cells;cellular microvillus;cellular transduction;Charge;Cochlea;Collaborations;Complex;Computer Simulation;Confocal Microscopy;Dedications;design;dimer;Educational process of instructing;Electrophysiology (science);Elements;empowerment;experimental study;extracellular;flexibility;forging;Gene Delivery;gene therapy;Goals;Hair;Hair Cells;Hearing;in silico;In Vitro;Inner Hair Cells;Ion Channel;Ions;Knowledge;Laboratories;Labyrinth;laser tweezer;Length;Link;link protein;Measures;mechanical force;mechanical stimulus;mechanotransduction;Mediating;Methods;microscopic imaging;miniaturize;Modeling;molecular dynamics;Mus;Mutagenesis;mutant;Nerve Fibers;novel;optic tweezer;Outer Hair Cells;PCDH15 gene;Peptides;Physiological;Physiological Processes;Process;Property;protein complex;Protein Dynamics;Proteins;Reporting;response;Roentgen Rays;Role;Scientist;Sensory;sensory system;Side;Site;sound;Stereocilium;Stimulus;Structural Models;Structure;Synaptic Transmission;Techniques;Technology;Testing;theories;therapy development;Time;tool;Training;vestibular system;Viral;viscoelasticity

PROJECT_TITLE: Investigating the role of tip link biophysics on MET function

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (15)]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The Data Management and Coordinating Center (DMCC) of the Rare Diseases Clinical Research Network (RDCRN) at Cincinnati Children’s will enhance clinical trial readiness of the RDCRN by advancing the methods and the practice of rare disease clinical and translational research. The DMCC will develop and share knowledge accumulated by the Network, including research data, study findings, and best practices, for use by all stakeholders studying, treating, or adversely affected by rare diseases. We will catalyze shared participation in the Network in order to transform the RDCRN into a collaborative community dedicated to the goal of better, faster, more impactful clinical research for rare diseases.

PI_NAMEs: KING, EILEEN CATHERINE (contact);MACALUSO, MAURIZIO ;WAGNER, MICHAEL

PROGRAM_OFFICER_NAME: URV, TIINA K

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;American;Authorization documentation;Caring;Categories;Characteristics;Child;Child Health;Childhood;Chronic;Clinical;clinical practice;Clinical Research;clinical trial readiness;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Communities;Comparative Effectiveness Research;Complex;Country;Data;Data Analyses;Data Coordinating Center;Data Element;data infrastructure;data integration;data management;data sharing;Decision Making;Dedications;Developed Countries;Diagnosis;Disease;disease classification;Dissemination and Implementation;Ecosystem;effective therapy;Eligibility Determination;Ensure;Epidemiology;Esapent;Etiology;European Union;evidence base;Face;Family;Functional disorder;Genetic;Genetic Diseases;Geography;Goals;Growth;Health;implementation strategy;improved;Individual;infancy;Informatics;Information Systems;Infrastructure;Institution;Investments;Knowledge;knowledge base;Leadership;Learning;Libraries;Life;Measures;meetings;Methods;National Center for Advancing Translational Sciences;Natural History;novel strategies;Observational Study;Outcome;Pathway interactions;patient engagement;Patients;Persons;Phase;phase III trial;Phenotype;Population;Privatization;Process;Production;programs;Protocols documentation;Public Health;Qualifying;Rare Diseases;rare genetic disorder;Recommendation;Regulation;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Resource Sharing;Resources;Secure;self organization;Standardization;Structure;System;Technology;Translating;Translational Research;trial readiness;Universities;user-friendly

PROJECT_TITLE: Data Management and Coordinating Center:  Rare Diseases Clinical Research Network


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE Between 4 and 6 years of age, children develop eating habits that last a lifetime, often with negative consequences for health. Flavor perception is a major determinant of food choices but is poorly understood among young children. The present proposal addresses this issue by investigating how different senses (taste and smell) contribute to flavor perception in early childhood, and how flavor perception relates to weight status.

PI_NAMEs: COLBERT, SARAH ELIZABETH (contact)

PROJECT_TITLE: Development of Retronasal Smell Perception in Young Children and Relation with BMI

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (46)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Spatial transcriptomics revolutionized cancer comprehension by allowing whole transcriptome analysis while maintaining the tumor architecture. With that the critical cell-to-cell interactions, that have been demonstrated to modulate tumorigenesis and responses to therapies, are preserved and can be characterized. In this new collaboration we will apply novel gene expression spatial experimental and computational tools to expand the DNA- and RNA-sequencing profiling to understand IPMN clonal evolution, and identify the microenvironment changes that follows premalignancy progression.

PI_NAMEs: FERTIG, ELANA ;KARCHIN, RACHEL ;WOOD, LAURA DELONG (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Architecture;Award;Cell Communication;Clinical;Clonal Evolution;Collaborations;Comprehension;Computational Technique;computerized tools;Diagnosis;diagnostic tool;DNA sequencing;Early Diagnosis;Early treatment;Evolution;Gene Expression;Genetic Transcription;Human;Image;interest;Investigation;Lesion;Malignant Neoplasms;Microscopic;Modeling;Molecular;Mucinous Neoplasm;novel;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;Papillary;Parents;Patients;Precancerous Conditions;premalignant;Premalignant Neoplasm;preservation;prevent;response;Sampling;Specimen;Systems Biology;Testing;Therapeutic Intervention;Tissues;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;tumorigenesis

PROJECT_TITLE: Interrogation of the Impact of Selection on the Evolution of Human PancreaticCancer Precursor Lesions


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE In the inner ear, disrupted axon guidance has been shown to result in altered neural circuit assembly, which may cause hearing loss or the ability to avoid damaging noise. Type II spiral ganglion neurons (SGNs) possibly act to protect and preserve cochlear structures by responding to damage and triggering noise-avoidance behaviors. In my proposed studies, I will determine mechanisms that control normal OHC innervation by type II SGNs. This will reveal insights into how a putative mammalian auditory pain system is established during development.

PI_NAMEs: GEORGE, DEBORAH JANE (contact)

PROJECT_TERMS: Adhesions;Auditory;Auditory system;avoidance behavior;Axon;axon guidance;base;Behavior;Biological Assay;career;career development;cell injury;Cells;Cochlea;Cochlear Implants;confocal imaging;Cues;Data;deafness;Defect;Development;Ephrins;Epithelial Cells;Epithelium;Event;experimental study;Family;G-Protein-Coupled Receptors;gene therapy;Growth Cones;Hair;Hair Cells;Hearing;hearing impairment;hearing preservation;Image;Immunohistochemistry;in vitro Assay;Incidence;Inner Hair Cells;insight;Knock-out;Knowledge;Label;Labyrinth;Ligands;Loudness;Maintenance;Mediating;member;Membrane;Mentors;Molecular;Morphology;mouse genetics;Mus;mutant;nerve supply;neural circuit;neurological pathology;neuron development;neuronal guidance;neuronal patterning;Neurons;Nociceptors;Noise;novel;Outer Hair Cells;Pain;Pathology;Pathway interactions;Pattern;Performance at work;Peripheral;Persons;planar cell polarity;Population;preservation;prevent;Process;Proteins;Publishing;Quality of life;Randomized;receptor;Reporting;Research;research and development;Research Personnel;Role;Secondary to;Severities;Signal Transduction;spiral ganglion;Structure;Synapses;synaptogenesis;System;Technology;Testing;Therapeutic;Training;transmission process;Work

PROJECT_TITLE: Molecular Mechanisms of Type II Spiral Ganglion Neuron Development


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Justice (the fairness of distribution according to what is deserved) and the related concept of equity (the absence of disparities according to levels of underlying social advantage/disadvantage) are core tenets of bioethics. This project will explore how stakeholders’ levels of aversion to inequity across contextually-relevant determinants of health affect the set of health services that are optimal to include in Eswatini’s health benefits package.

PI_NAMEs: BERSHTEYN, ANNA  (contact);REVILL, PAUL

PROGRAM_OFFICER_NAME: VITALIS, DEBBIE

PROJECT_TERMS: Address;Adult;Affect;Africa;base;Belmont Report;Benchmarking;Beneficence;Bioethics;Bioethics Consultants;Budgets;Canada;cardiovascular disorder prevention;care systems;Central Africa;Characteristics;Clinic;Community Health;Country;Decision Making;design;Diabetes Mellitus;Dimensions;disability-adjusted life years;Disadvantaged;Disparity;Eastern Africa;Educational Status;Educational workshop;Ensure;Equity;Ethics;Future;Gender;General Population;Goals;Health;Health Benefit;Health Care Reform;health determinants;health disparity;health inequalities;Health Services;Healthcare;High Prevalence;HIV;HIV diagnosis;human subject protection;Hypertension;improved;indexing;Individual;Inequity;Infrastructure;insight;Justice;Life Expectancy;Literature;low and middle-income countries;Malawi;Measures;meetings;Methods;National Health Services;Outcome;parent project;Parents;Persons;Policies;Population;process optimization;professor;Research;Research Activity;Research Priority;Resource-limited setting;Resources;Rural;Rural Health;Services;Shapes;social;Socioeconomic Status;Southern Africa;Techniques;Uganda;Universities;Update;Urban Hospitals;Viral Load result;virtual;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Leveraging HIV care systems to improve cardiovascular disease prevention in the Kingdom of eSwatini

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Individuals with excessive alcohol use demonstrate altered brain responses while engaging with alcohol-related information. However, little is known about how the inability to disengage after such experiences (i.e., persistent processing) may contribute to alcohol consumption. In this proposal, I will leverage innovative brain dynamic methods and a novel behavioral task to identify neural and cognitive markers of persistent processing and elucidate their roles in risky drinking.

PI_NAMEs: YE, JEAN  (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: addiction;Affective;Alcohol abuse;Alcohol consumption;alcohol craving;alcohol exposure;alcohol involvement;alcohol memory;alcohol use disorder;Alcohols;Attention;Behavioral;Biological Psychiatry;biomarker identification;Brain;Brain region;career;Cognitive;cognitive control;Communities;computerized tools;craving;Data;Data Analyses;Data Collection;design;drinking;drinking behavior;emotion regulation;Etiology;Event;experience;flexibility;Functional Magnetic Resonance Imaging;Future;Heavy Drinking;high risk;high risk drinking;Hour;Image;Individual;innovation;Intervention;Investigation;Life;Light;Link;Literature;Measures;Memory;Methods;Mind;Motivation;neural;Neurobiology;neuroimaging;neuromechanism;novel;Participant;Persons;Play;Population;Process;Psychopathology;Publications;Recovery;Research;response;Rest;reward processing;risk mitigation;Role;Sampling;Scanning;Series;skills;Statistical Methods;Stimulus;Techniques;Telephone;Testing;Thinking;Time;Training;Walking;Work

PROJECT_TITLE: Investigating neural and behavioral indications of persistent alcohol-related thoughts

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project serves to determine how the c.-14C>T point mutation in the 5’ untranslated region of the osteoblast gene, IFITM5, causes the brittle bone disease osteogenesis imperfecta type V (OI-V). Specifically, this project will investigate the role of the TGF-β signaling pathway in OI-V development and determine the efficacy of therapies that target either the TGF-β signaling pathway or the OI-V causative mutation to promote normal osteoblast development. This research hopes to identify a novel mechanism of OI-V pathogenesis and validate the efficacy of novel OI-V therapies using preclinical models.

PI_NAMEs: BUSSE, EMILY  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 5' Untranslated Regions;Address;Adipocytes;Affect;Alleles;Amino Acids;Animal Model;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Binding;Biopsy;bisphosphonate;bone;Bone callus;Bone Density;bone fragility;Bone Marrow;bone mass;Bone Resorption;calcification;causal variant;Cell Line;Cells;Chondrocytes;clinical phenotype;Clinical Trials;COL1A1 gene;COL1A2 gene;Collagen;Collagen Fiber;Collagen Type I;Complementary DNA;Cre driver;Data;Data Correlations;Defect;Deformity;density;Development;Differentiation Antigens;differentiation in vitro;Disease;disease-causing mutation;Dislocations;efficacy evaluation;efficacy validation;Epiphysial cartilage;FDA approved;Femur;Fibroblasts;Fracture;Genes;Genetic;Goals;Growth and Development function;Head;Heterozygote;Human;Hyperplasia;improved;In Vitro;in vivo;induced pluripotent stem cell;Inherited;inhibitor;Initiator Codon;insight;Integral Membrane Protein;Investigation;Limb structure;Live Birth;long bone;MADH2 gene;Mediating;Mediator;Membrane;Mesenchymal;Mesenchymal Differentiation;Mesenchymal Stem Cells;Mesenchyme;mineralization;Modeling;mouse model;Mus;mutant;Mutation;neurogenetics;novel;off-label use;osteoblast differentiation;Osteoblasts;Osteocytes;Osteogenesis Imperfecta;Pathogenesis;Pathogenicity;Patient Care;Patients;Perinatal mortality demographics;Phenotype;Point Mutation;Post-Translational Protein Processing;postnatal;pre-clinical;Pre-Clinical Model;preclinical development;preclinical study;Preclinical Testing;prevent;promoter;Proteins;Radial;Recurrence;Repression;Research;Role;Signal Transduction;Site;skeletal;skeletal abnormality;skeletal dysplasia;spine bone structure;standard of care;Symptoms;targeted treatment;Testing;TGF Beta Signaling Pathway;therapeutic development;trafficking;Transcriptional Activation;Transforming Growth Factor beta;translational potential;Variant

PROJECT_TITLE: INVESTIGATING THE CONTRIBUTION OF OSTEOBLAST DIFFERENTIATION IN THE PATHOGENESIS OF OSTEOGENESIS IMPERFECTA TYPE V

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative This research project aims to assess the potential for using brain-computer interfaces to improve communication in people with aphasia. The study will develop approaches for modeling and decoding semantic representations in people with aphasia using linguistic and non-linguistic stimuli. Findings will improve human health and well-being by assessing how new communication channels can be developed to assist people with language disorders.

PI_NAMEs: TANG, JERRY  (contact)

PROJECT_TERMS: Affect;animation;Aphasia;Area;Brain;brain computer interface;career;Clip;Communication;Communication impairment;Comprehension;Data;design;Development;Disabling;Educational workshop;experience;Experimental Designs;experimental study;Expressive Aphasia;Feedback;Fellowship;Foundations;Functional Magnetic Resonance Imaging;Goals;Health;Hour;Human;Impairment;improved;Language;language comprehension;Language Disorders;language impairment;language training;Linguistics;Maps;Mentorship;Modeling;Moths;Motor;Movement;movie;natural language;neuroimaging;Neurologic;Participant;Patient Recruitments;Personal Satisfaction;Persons;preservation;Process;Production;Radio;recruit;Reporting;Research;Research Project Grants;response;Semantics;skills;Speech;Speech Disorders;Stimulus;Stroke;stroke-induced aphasia;System;Testing;Thinking;Training;training data;Transcript;Translating;visual stimulus

PROJECT_TITLE: Assessing semantic encoding and decoding models in stroke-induced aphasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This project aims to investigate whether mentalizing abilities emerge as a cognitive strength and protective factor among youth living in environments characterized by structural inequality. Results from this study will improve knowledge of the way neural function and cognition is shaped by the environment and will help identify protective factors that can be leveraged to promote positive mental health outcomes.

PI_NAMEs: NAVARRO, ESMERALDA  (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affective;Age;Area;Behavior;Behavioral;Brain;Child;Childhood;cingulate cortex;Cognition;Cognitive;cognitive process;Collaborations;Development;Developmental Process;Diagnostic;disadvantaged background;Disparity population;Dorsal;Economics;Education;emotion regulation;Emotions;Empathy;Environment;experience;Exposure to;Functional Magnetic Resonance Imaging;improved;Income;Individual;Inequality;Institution;Intervention;Knowledge;Learning;Link;Literature;Lived experience;Longitudinal Studies;Low income;Low Income Population;Maintenance;Measures;Medial;Mediating;meetings;Mental Health;mental state;mentalization;Mentorship;Methods;multimodality;National Institute of Mental Health;neural;neural correlate;neural network;neurodevelopment;neuroimaging;Neurophysiology - biologic function;Neurosciences;novel;Outcome;Patient Self-Report;Performance;perspective taking;positive youth development;Poverty;Prefrontal Cortex;Process;protective factors;Psychopathology;Reading;Reporting;Research;research facility;research study;Research Support;resilience;Resources;response;Risk;Risk Factors;Sampling;Shapes;skills;social capital;Social Processes;social relationships;Social support;Strategic Planning;Structure;Structure of superior temporal sulcus;Testing;theories;Thinking;Time;United States;Work;working class;Youth

PROJECT_TITLE: Investigating Mentalizing as a Cognitive Strength and Protective Factor Among Youth Impacted by Structural Inequality

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Sulggi Lee PROJECT NARRATIVE Methamphetamine (MA) use is highly prevalent among HIV+ individuals and is likely to pose challenges for achieving an HIV cure in these individuals, even with effective antiretroviral therapy (ART) suppression. HIV+ ART-suppressed individuals with a history of MA use will be studied to determine whether MA increases virus production and systemic inflammation, and to identify the genes and immunologic pathways that drive MA- induced effects. Data obtained during the course of this study should contribute important and novel genetic and immunologic data to the HIV cure and psychostimulant addiction research agenda.

PI_NAMEs: LEE, SULGGI ANGELA (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Adult;Amines;animal data;Antigen Presentation;antiretroviral therapy;aspirate;Biological Markers;Blood;CD4 Positive T Lymphocytes;Cell Cycle Regulation;Cells;Clinical;Clinical Research;Collaborations;Collection;CRISPR/Cas technology;cytokine;Data;Detection;differential expression;Disease;DNA;Drug Targeting;Enrollment;exhaustion;experience;experimental study;Face;Flow Cytometry;Future;Gene Expression;gene-editing approach;Genes;Genetic;Genetic study;Genetic Transcription;Goals;Hair;HIV;HIV anti-retroviral;HIV Genome;HIV-1;Hour;Human;Human Genetics;human study;Immune;immune activation;immune modulating agents;Immune response;Immune System Diseases;Immunologics;in vivo;Individual;Inflammation;Inflammatory;Interleukin-10;Interleukin-6;Intervention;Intervention Studies;Knock-out;Link;Long-Term Effects;Longitudinal cohort study;lymph nodes;Lymphoid Tissue;Measures;Mediating;Methamphetamine;methamphetamine effect;methamphetamine exposure;methamphetamine use;Modeling;Molecular;Monitor;National Institute of Drug Abuse;Natural experiment;Nature;novel;Oral Administration;overexpression;Participant;Pathway interactions;Placebos;Plasma;Population;pre-clinical;Production;programmed cell death ligand 1;protein activation;protein expression;Protein Kinase C;purge;receptor;Recording of previous events;Regulation;Reporting;Research;Research Design;Research Priority;Residual state;RNA;RNA Splicing;Sampling;San Francisco;Signal Transduction;statistics;Stimulant;stimulant dependence;Substance Addiction;substance use;systemic inflammatory response;Testing;Therapeutic;therapy adherence;TNF gene;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Transforming Growth Factor beta;urinary;Validation;Viral;Virus;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Depression is a highly prevalent and disabling mental illness and, despite considerable research into pathophysiological mechanisms and treatments, treatment response remains heterogeneous and it is difficult to predict how an individual will (or will not) respond to a specific treatment. There is evidence that psychomotor disturbance (e.g., psychomotor slowing) may be indicative of pathogenic mechanisms and an effective predictor of illness course and treatment response; however, current assessment methods are subject to bias and there is limited understanding of biological markers of this dysfunction. Examining the relationship between biomarkers of motor dysfunction which have been observed in other populations (e.g., Parkinson’s), instrumental measurements of psychomotor disturbance, and key outcomes (e.g., symptomatology, functioning, quality of life) has considerable potential for developing novel treatments and improving personalized treatment recommendations.

PI_NAMEs: ZARUBIN, VANESSA C. (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Accounting;Acute;Agitation;Area;Basal Ganglia;Behavioral;Biological Markers;biomarker validation;Brain region;Career Choice;Characteristics;Clinical;clinical predictors;Code;Depressed mood;depressive symptoms;design;Diagnosis;diagnostic tool;Disabling;Disease remission;Educational workshop;Electrodes;Electroencephalography;Environment;Equipment;Exhibits;follow-up;Foundations;Functional disorder;functional outcomes;Funding;Globus Pallidus;improved;indexing;Individual;individualized medicine;Inferior;Institution;Investigation;Levodopa;Link;Lobule;Longitudinal Studies;Major Depressive Disorder;Measurement;Measures;meetings;Mental Depression;Mental disorders;Methodology;Methods;Motor;Motor Cortex;motor disorder;neural;normal aging;novel;Outcome;Parietal;Parkinson Disease;Parkinsonian Disorders;Participant;Pathogenicity;Pathology;Patient Self-Report;personalized medicine;Phase;Population;Posture;Predictive Value;Prevalence;prognostic;programs;Quality of life;Recommendation;reduce symptoms;Relapse;Research;Research Design;Resources;Rest;Role;Sampling;Scientist;severe mental illness;Severities;Site;skills;sound;Specificity;Statistical Data Interpretation;symposium;symptomatology;Symptoms;Techniques;Thalamic structure;theories;therapy development;Time;Training;treatment response;Universities;years lived with disability

PROJECT_TITLE: EEG Coherence as a Biomarker for Psychomotor Disturbance and Course of Depression


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE The differential diagnosis of childhood apraxia of speech (CAS), a pediatric speech disorder that affects between 60,000 and 780,000 children under 14 in the US, remains difficult in clinical and research settings. This difficulty is due in large part to the reliance on diagnostic techniques that can be subjective and prone to bias, resulting in inconsistent diagnostic and treatment outcomes for children in this population. This project systematically investigates the validity and potential differential diagnostic accuracy of a well-motivated set of objective acoustic measures in a large retrospective sample of children with and without CAS to help improve accurate diagnosis and thereby support more effective treatment decisions and outcomes for children with CAS.

PI_NAMEs: LITTLEJOHN, MEGHAN  (contact)

PROJECT_TERMS: accurate diagnosis;Acoustics;Address;Affect;Analysis of Variance;Articulation;career;Child;Childhood;Clinical;clinical diagnosis;clinical efficacy;Cognition;Communication;Communication impairment;Consensus;Data Set;Development;Developmental apraxia;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;diagnostic value;Differential Diagnosis;Disease;effective therapy;Emotional;Evaluation;evidence base;experience;Foundations;Future;Goals;Grain;Heterogeneity;high risk;Impairment;improved;Individual;Intervention;Judgment;Language;large datasets;Lead;lexical;literacy;Literature;Measures;Motor;motor control;Multivariate Analysis;novel;Outcome;Pathologist;Population;Process;programs;prospective;Prospective Studies;Reading;Research;Research Personnel;Risk;Sample Size;Sampling;Selection for Treatments;Sensitivity and Specificity;skills;social;sound;Specificity;Speech;Speech Disorders;Speech Sound;Stress;Training;Treatment outcome;Uncertainty;United States;validation studies;Work;Writing

PROJECT_TITLE: Acoustic Measures in Diagnosis and Subtyping of Childhood Apraxia of Speech


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Obesity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE The proposed study is relevant to public health because diabetes and COVID-19 disproportionately affect racial and ethnic minorities. It is important to understand the intersection of social determinants of health and underlying biologic risk of developing diabetes to improve health equity. A more comprehensive understanding of factors influencing health outcomes in racial and ethnic minorities will inform targeted interventions to further advance the NINR mission to improve population and community health.

PI_NAMEs: KEELS, JORDAN  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: 2019-nCoV;Active Learning;Acute;Acute Respiratory Distress Syndrome;Address;Admission activity;Adrenal Cortex Hormones;Adult;Affect;autoimmune pathogenesis;Beta Cell;Big Data Methods;Biological;Biological Factors;Biology;Blood Vessels;Boston;cerebrovascular;Cessation of life;Clinical;college;Communities;Community Health;comorbidity;Complement;Containment;COVID-19;COVID-19 diagnosis;COVID-19 impact;Data;Databases;Death Rate;Detection;Development;Diabetes Mellitus;diabetes risk;Discipline of Nursing;disparity reduction;Early Diagnosis;Economics;Endocrine system;Endocrinology;Environment;Environmental Risk Factor;epidemiology study;ethnic minority;ethnic minority population;Event;experience;experimental analysis;Fellowship;formal learning;Genetic;genetic architecture;Genetic Determinism;genome wide association study;Health;Health Care Costs;health disparity;health equity;health equity promotion;Health Services Accessibility;Health Surveys;Healthcare;Heart failure;high risk;high risk population;holistic approach;Home;Hormonal Change;Hyperglycemia;Iatrogenesis;improved;Individual;Inflammation;Injury;Institution;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intensive Care;Intervention;Kidney Diseases;Knowledge;learning strategy;lens;Link;Long COVID;Low income;macrovascular disease;marginalized community;marginalized population;Measures;Mental Depression;Mentors;Mentorship;Meta-Analysis;Metabolic dysfunction;Methodology;Methods;Minority Groups;Mission;Morbidity - disease rate;mortality;Myocardial Infarction;Nature;neighborhood disadvantage;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nurses;Obesity;Outcome;Pancreas;pandemic disease;Patient-Focused Outcomes;Peripheral Vascular Diseases;Persons;population health;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Prediabetes syndrome;Prevalence;professional atmosphere;prospective;Public Health;Publishing;racial minority;racial minority population;Reporting;Research;Resolution;Resources;Respiratory Failure;Respiratory Tract Infections;Retinal Diseases;Risk;Risk Factors;SARS-CoV-2 infection;School Nursing;Science;Scientist;severe COVID-19;skills;social;social factors;social health determinants;Societal Factors;Statistical Data Interpretation;Stress;Structure;Structure of beta Cell of islet;Surveys;Symptoms;System;systematic review;Training;training opportunity;Underserved Population;United States;United States National Institutes of Health;Variant;Virus Diseases;Work

PROJECT_TITLE: An epidemiological study to investigate the multifactoral nature of diabetes risk among adults with COVID-19 with a genetic and social determinants of health lens

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (90)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PHR: PROJECT NARRATIVE This project aims to characterize neurodevelopmental mechanisms underlying the association of early childhood adverse experiences involving deprivation with pediatric psychopathology. The proposed research will improve understanding of neurodevelopmental risk for adverse mental health outcomes by identifying pathways of frontoparietal network development linking deprivation with psychopathology first in early childhood and then longitudinally from early childhood through adolescence. Findings will have implications for population health by identifying pathways of transdiagnostic psychopathology risk that can inform future early intervention efforts for childhood adversity, which impacts nearly 50% of children and adolescents in the United States.

PI_NAMEs: LURIE, LUCY  (contact)

PROJECT_TERMS: 7 year old;Address;Adolescence;Adolescent;Adult;adverse childhood events;Adverse event;Age;Area;Biological Markers;Brain;caregiving;Child;Child Abuse and Neglect;Childhood;childhood adversity;Cognitive;cognitive control;cognitive function;Cross-Sectional Studies;Data;deprivation;Development;Diagnostic;Dimensions;early childhood;early experience;Early Intervention;early life adversity;Environment;executive function;experience;Exposure to;Functional Magnetic Resonance Imaging;Future;Goals;improved;Individual;Influentials;Institution;intraparietal sulcus;life span;Link;Literature;Longitudinal cohort;Magnetic Resonance Imaging;Mediating;Mental disorders;Mental Health;middle childhood;Modeling;National Institute of Mental Health;neglect;neural;Neurobiology;neuroimaging;Neurophysiology - biologic function;Outcome;Parietal Lobe;Pathway interactions;Performance;population health;Population Heterogeneity;Prefrontal Cortex;Proliferating;prospective;Psychopathology;psychosocial;Public Health;recruit;Research;Resources;Risk;Risk Factors;Sampling;Shapes;Strategic Planning;Structure;Synapses;theories;Thick;Thinness;Training;United States;Youth

PROJECT_TITLE: Early Childhood Deprivation and Psychopathology: Identifying Neurodevelopmental Pathways of Risk


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Contact PD/PI: Rijo-Ferreira, Filipa Project Narrative Malaria parasites invade, replicate and burst host’s red blood cells in a synchronized manner, leading to rhythmic fevers. The proposed research will investigate how malaria parasites process daily rhythms within their hosts to regulate the synchronized development. When parasite and host rhythms are mismatched, infection is disturbed, therefore, uncovering the mechanism by which malaria coordinate their 24h periodicity will have an impact on understanding and treating this deadly infection. Project Narrative

PI_NAMEs: RIJO-FERREIRA, FILIPA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Bacteria;Behavior;Bite;Blood;Blood Cell Count;burden of illness;Cell Cycle;Cell Cycle Completion;Cell division;Cells;Chronic;circadian;Circadian gene expression;circadian pacemaker;Circadian Rhythms;Compensation;Culicidae;Darkness;Data;Development;Disease;Dissection;Diving;Drops;Environment;Erythrocytes;Fever;fitness;Foundations;Gene Expression;Genes;Genetic;Genetic Transcription;global health;Goals;Hormonal;Hormones;Human;In Vitro;Infection;Invaded;Jet Lag Syndrome;Knowledge;Life;Life Cycle Stages;life span;Light;Malaria;malaria infection;Mammalian Cell;Measures;Metabolic;mouse model;Mus;Mutant Strains Mice;Mutation;next generation sequencing;novel;Nutrient;Nutritional status;Organism;Output;Parasite Control;parasite invasion;Parasites;Parasitic Diseases;Parasitic infection;Pathway interactions;Periodicity;Persons;Phase;Physiological;Plasmodium;Population;Principal Investigator;Process;Property;Recurrence;Research;Rodent;Rupture;Salivary Glands;Signal Transduction;Sporozoites;success;Symptoms;System;Technical Expertise;Temperature;Testing;transcriptome;transmission process;Wild Type Mouse;Work

PROJECT_TITLE: Elucidating the mechanism for malaria rhythmicity: an underlying circadian clock of the parasite

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Skin-penetrating parasitic nematodes cause significant global health burdens that disproportionately impact socioeconomically disadvantaged communities. This proposal aims to identify and characterize the behavioral and neural mechanisms mediating odor-evoked host seeking and host invasion in the human-parasitic, skin- penetrating nematode Strongyloides stercoralis. Findings from this work will generate fundamental insight into parasitic nematode chemosensory biology that will inform future preventative and control methods.

PI_NAMEs: GONZALEZ AKIMORI, DAMIA  (contact)

PROJECT_TERMS: Afferent Neurons;Ancylostoma (genus);Anthelmintics;Automobile Driving;Behavior;Behavioral;Behavioral Mechanisms;behavioral response;Biology;Caenorhabditis elegans;Chemoreceptors;Child;Chronic;climate change;Computer software;Cues;Development;Disease;Drug resistance;Enterobius;Environment;Esthesia;experimental study;Family;functional adaptation;Future;G-Protein-Coupled Receptors;gastrointestinal infection;Genetic;genetic manipulation;global health;Goals;Growth;Health;Healthcare;Hookworms;Human;immunosuppressed;In Vitro;in vivo calcium imaging;Individual;Infection;Infrastructure;insight;Invaded;Larva;Life;Livestock;Managed Care;Mediating;Methods;Modeling;mortality;Motility;Necator;neglect;neighborhood disadvantage;Nematoda;Nematode infections;neural;neuromechanism;Neurons;new therapeutic target;novel;novel strategies;Odors;Parasites;Parasitic nematode;parasitism;Pattern;Penetration;Pharmaceutical Preparations;Pharmacotherapy;prevent;Prevention;Prevention strategy;Process;Property;Rattus;receptor;Receptor Gene;Research;Resistance;Respiratory distress;response;Role;Sensory;sensory mechanism;Sequence Homology;Skin;socioeconomic disadvantage;Specificity;Speed;Strongyloides ratti;Strongyloides stercoralis;Testing;tool;Transmembrane Domain;Waste Management;Work

PROJECT_TITLE: Behavioral and neural mechanisms of chemosensation in skin-penetrating parasitic nematodes


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

PHR: Project Narrative This proposal will provide the most comprehensive study to date of H. pylori, other Helicobacter infection and liver cancer in both African Americans (AAs) and whites by using a pooled nested case-control study. Results from this proposal have etiologic relevance and clinical impact by identifying (1) a novel bacterial infection for non-viral liver cancer; and (2) race/ethnic-specific Helicobacter infection associated with liver cancer that will inform designing interventions to reduce existing disparities, given the high prevalence of H. pylori infection in AAs in the U.S. These investigations into the associations between bacterial infections and liver cancer risk will also advance the field of liver cancer etiology, prevention, and case management.

PI_NAMEs: ZHANG, XUEHONG  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Affect;African American population;angiogenesis;Animal Experiments;Animals;Antibody Response;Bacteria;Bacterial Infections;Biological Assay;Blood specimen;Cancer Etiology;cancer health disparity;cancer risk;carcinogenicity;Carcinoma;Case Management;Cessation of life;chronic infection;Clinical;co-infection;cohort;Cytotoxin;Data;design;Diabetes Mellitus;Diagnostic;Disparity;DNA Damage;epidemiology study;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;Goals;Grant;Growth;Helicobacter;Helicobacter hepaticus;Helicobacter Infections;Helicobacter pylori;Hepatitis B Infection;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatocarcinogenesis;Hepatocyte;High Prevalence;Human;Incidence;Infection;innovation;Intervention;Invaded;Investigation;Liver;Malignant neoplasm of liver;Measures;men;Metabolic Diseases;mortality;Mouse Strains;Nested Case-Control Study;Not Hispanic or Latino;novel;novel strategies;Obesity;Odds Ratio;Pathogenicity Island;Population;Predisposition;Prevalence;prevent;Prevention;Prospective Studies;Prospective, cohort study;Proteins;Race;racial diversity;racial minority;racial population;Research;Resources;Risk;Risk Factors;Role;seropositive;therapy design;Tissues;United States;Viral;viral carcinogenesis;Virulence Factors;Virus Diseases;Woman;Work

PROJECT_TITLE: Helicobacter Infection and Liver Cancer Risk among African Americans andWhites in the United States

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Serious Mental Illness;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: FORDHAM UNIVERSITY

PHR: Previous research has found that sexual minority people are at increased risk for psychopathology, including Obsessive Compulsive Disorder (OCD). Further, sexual minority people experience unique stressors (e.g., discrimination), but the associations between these stressors and OCD severity and treatment outcomes have yet to be examined. As such, the current project aims to identify the roles of general versus sexual minority- specific risk factors in OCD severity and treatment outcomes among sexual minority people with OCD.

PI_NAMEs: BEZAHLER, ANDREAS  (contact)

PROJECT_TERMS: Address;Admission activity;Adult;Affect;Anxiety;Area;Belief;Characteristics;Clinical;clinical outcome measures;Clinical Research;comorbidity;Consent;Data;demographics;Development;Diagnosis;Discrimination;Disparity;Distress;Elasticity;emotion dysregulation;Evidence based intervention;Expectancy;experience;General Population;Grant;health inequalities;Heterosexuals;Hospitals;improved;Individual;innovation;interest;internalized stigma;Lesbian Gay Bisexual;Light;Machine Learning;machine learning method;Measures;Mental Depression;Mental Health;Methods;minority patient;minority stress;minority stressor;Modeling;Monitor;Obsessive-Compulsive Disorder;Outcome;Participant;Patients;Performance;Persons;Phobias;Pilot Projects;Population;predict clinical outcome;primary outcome;Prognosis;programs;Psychopathology;Public Health;Quality of life;recruit;Reporting;Research;Residential Treatment;Risk;Risk Factors;Role;Sampling;secondary outcome;Severities;Sex Orientation;sexual minority;sexual minority group;sexual minority health;sexual minority stress;Statistical Methods;Stress;stressor;Symptoms;Training;Trauma;Treatment outcome;treatment research;treatment response;Work;Writing

PROJECT_TITLE: Determining the role of discrimination in clinical presentation and treatment response among sexual minority people with OCD: A machine learning approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Olfaction and memory are intimately intertwined, demonstrated by unique neural circuitry, and highlighted by the loss of smell in memory-based disorders, such as Alzheimer's disease. The proposed research aims to probe the cellular identity of odor stimulus decision-predicting time cells, the importance of their divergent time tiled activity in the context of behavior, and the contributions of PV interneurons to these cells regulated activity. The outcomes of this research will not only help to guide further research into divergent pyramidal cell behavior in the hippocampus but will also contribute to the greater understanding of how olfactory memories are stored and recalled, laying foundational groundwork for possible memory recovery in patients with memory loss.

PI_NAMEs: STEINKE, KIRA A (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Animals;Anosmia;Association Learning;Behavior;behavioral response;Binding;Biological Process;Brain;calbindin;calretinin;cell behavior;Cells;Complex;conditioned fear;Country;Decision Making;discrete time;Discrimination Learning;discrimination task;Disease;Dorsal;Educational process of instructing;emotion regulation;Emotions;Environment;Episodic memory;Esthesia;Exhibits;experience;genetic approach;Halorhodopsins;hippocampal pyramidal neuron;Hippocampus;holographic stimulation;Image;Impairment;Interneurons;Label;Learning;Left;Lesion;Link;Literature;Mediating;Memory;Memory impairment;Memory Loss;memory retrieval;Molecular;Mus;Nature;neural;neural circuit;Neurologic;Odors;olfactory stimulus;Optics;optogenetics;Outcomes Research;Parvalbumins;Patients;Pattern;Persons;Play;Population;Process;Pyramidal Cells;Recovery;Research;response;Response to stimulus physiology;Retrieval;Role;Sampling;Smell Perception;Source;Stimulus;Structure;Synapses;Techniques;Temporal Lobe;Testing;Time;trend;two photon microscopy;two-photon;United States;Work

PROJECT_TITLE: Employing holographic stimulation to probe the cellular basis of the engram for odor epochs.


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: RELEVANCE: Given the disproportionate burden of cardiovascular disease in rural areas, particularly in the southeastern portion of the United States, the proposed study will investigate the impact of distinctive structural processes of disinvestment in rural areas that influence neighborhood opportunity and vulnerability. This proposal focuses neighborhood measures of disinvestment, social vulnerability, and racial and economic isolation to investigate associations with CVD risk factors leveraging the Risk Underlying Rural Areas Longitudinal Study (RURAL). Findings from this research may help to identify macrosocial drivers of cardiovascular risk and disparities in rural communities.

PI_NAMEs: BENJAMIN, LARISSA  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;aged;Alabama;Appalachian Region;Area;Automobile Driving;Black race;Blood Pressure;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Censuses;Cessation of life;cohort;Complex;Data;deprivation;Diabetes Mellitus;Disparity;Economics;Environment;Environmental Pollution;ethnic disparity;Ethnic Origin;Ethnic Population;Face;Fellowship;Goals;Health;health equity;health inequalities;High Prevalence;Incidence;indexing;Individual;Inequity;Injury;Kentucky;Knowledge;Life;Link;Longitudinal Studies;Louisiana;Measures;Mentorship;Minor;Mississippi;mortality;Natural Disasters;Nature;Neighborhoods;Obesity;Outcome;Persons;Phase;Population;Poverty;Prevalence;Process;Public Health Practice;Public Health Schools;Race;racial disparity;racial minority population;recruit;Research;residence;residential segregation;Risk;Risk Factors;Role;Rural;rural Americans;rural area;Rural Community;rural counties;Rural Health;rural residence;rurality;segregation;Shapes;social;social health determinants;Social isolation;social vulnerability;socioeconomic disparity;Socioeconomic Status;socioeconomics;Stress;Stroke Belt;United States;urban area;urban setting;Variant;Work

PROJECT_TITLE: Understanding the Macrosocial Drivers of Cardiovascular Health in the Rural South


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE Community health workers (CHWs) play a crucial role in reducing health disparities by improving health care access and mitigating the impacts of social determinants of health. As community health workers tend to be part of or closely affiliated with the communities they serve, they often experience many of the same social risk factors as their clients. Exploring how community health workers experience integration into clinical settings can improve how programs are designed to support their professional quality of life and enhance the quality and effectiveness of health care services.

PI_NAMEs: FULLER, SHANNON  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Area;Behavior;Behavioral Sciences;burnout;cardiometabolism;career;Caring;Characteristics;Client;Clinic;Clinical;clinical care;Clinical Services;Collection;Communities;community based participatory research;community engaged research;Community Health Aides;community organizations;Community Surveys;Complement;Consensus;Consolidated Framework for Implementation Research;cultural competence;Data;Data Analyses;Data Collection;Dedications;design;disenfranchised population;Disparity;Disparity population;disparity reduction;dissemination strategy;Doctor of Philosophy;Education;Effectiveness;ethnographic method;Ethnography;Evidence based intervention;experience;Fellowship;Fostering;Goals;Grant;Health;health care availability;Health care facility;health care service;health care settings;health disparity;Health education;health equity;Health equity research;health outcome disparity;Health Personnel;Health Services Research;Healthcare;implementation context;implementation determinants;implementation framework;implementation science;improved;Individual;insight;Institution;integrated care;interest;Intervention;Interview;Literature;marginalization;Maryland;Measures;Medical;meetings;member;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute on Minority Health and Health Disparities;Outcome;participant observation;patient navigation;Patient-Focused Outcomes;Patients;Pattern;perceived stress;Play;Population;Positioning Attribute;Process;programs;Public Health Schools;Quality of Care;Quality of life;recruit;Reduce health disparities;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Risk Factors;Role;skills;social;social disparities;social health determinants;Social Sciences;socially disenfranchised;Stress;Supervision;Surveys;Theoretical Domains framework;theories;Training;Training Activity;Translations;United States;Work;Workplace;Writing

PROJECT_TITLE: Applying a Health Equity Lens to Explore Community Health Workers' Integration into Clinical Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Bone is one of the most widely transplanted tissues in the world, however, the complex mechanisms that underlie bone formation after injury remain incomplete. Nerves have been shown to play a role in modulating bone healing, yet their interactions with bone forming cells, such as osteoprogenitors, have not been fully elucidated. By understanding these interactions, we can identify potential therapeutic targets to encourage bone formation following injury or disease.

PI_NAMEs: HORENBERG, ALLISON  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;ACTL6B gene;afferent nerve;Atlases;bone;Bone Formation Stimulation;Bone Growth;bone healing;Bone Injury;bone loss;Bone Regeneration;Bone Tissue;Calcitonin Gene-Related Peptide;Calvaria;Cell Proliferation;cell type;Cells;Communication;Complex;Conditioned Culture Media;craniofacial;craniofacial bone;cranium;Data;Defect;density;Deposition;Development;Disease;Distal;Exhibits;fluorescence imaging;Ganglia;Genomics;Harvest;healing;high resolution imaging;Image;imaging modality;improved;In Vitro;in vivo;Infiltration;Injury;Knock-in;Label;Ligands;Light;Literature;long bone;Mediating;Methods;Microscopy;mineralization;Minerals;Mus;Mutation;Nerve;neural;Neurons;neurotransmission;Optics;Osteogenesis;osteoprogenitor cell;Parietal bone structure;Pattern;Peripheral Nerves;Phenotype;Play;Process;Proliferating;Proteins;receptor;Resolution;Role;Scanning;Signal Transduction;single-cell RNA sequencing;skeletal;Small Interfering RNA;spatiotemporal;Stains;stemness;Structure of trigeminal ganglion;Techniques;Testing;Therapeutic;therapeutic target;Three-Dimensional Imaging;Tissue Transplantation;Tissue-Specific Gene Expression;Tracer;transcriptomics;treatment strategy;Visualization

PROJECT_TITLE: Investigating neuroskeletal interactions in non-healing calvarial defect injuries

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (18)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Sleep Research

PHR: PROJECT NARRATIVE American adolescents are currently experiencing high rates of anxiety and mood disorders, signaling potential short- and long-term consequences for mental health and well-being. Neuroinflammation, linked to circadian dysregulation in the neuroimmune system, is considered a risk factor for psychiatric disorders and presents a unique targetable mechanism for novel therapies and treatment. The proposed research aims to explore the development of circadian rhythms in neuroimmune tissues and investigate whether early-life perturbations to the circadian system contribute to enduring behavioral changes.

PI_NAMEs: BELL, KIERSTEN SIMONE (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Adolescent;Adult;American;Anxiety;Anxiety Disorders;ARNTL gene;autism spectrum disorder;Behavior;Behavioral;Biological Clocks;Biological Process;Biological Rhythm;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Body System;Brain;brain cell;Cd68;Cells;Central Nervous System;Chronic;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Conceptions;Cre lox recombination system;Crying;Darkness;Data;Development;Diagnosis;digital;Disease;Early Intervention;Eating;effective therapy;Electricity;emerging adult;Emotional;Environment;Environmental Exposure;Event;experience;Exposure to;Female Adolescents;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Health Promotion;Homeostasis;Hormones;Hour;Immune;immune activation;Immune system;Immunologic Surveillance;Immunology;Impaired cognition;improved;Individual;Industrialization;Inflammation;Inflammatory;insight;Interleukin-1 beta;Intervention;invention;Jet Lag Syndrome;Knock-out;knockout gene;Lead;Life;Light;Lighting;Link;Long-Term Effects;Meninges;Mental Depression;Mental disorders;Mental Health;Microglia;Modeling;Molecular;Mood Disorders;Moods;Morphology;Mus;neural;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;Neuroimmune system;neuroinflammation;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel;novel therapeutics;Organ;Organism;Outcome;pathogen;Pathogenesis;Pathology;Pattern;Periodicity;Peripheral;Personal Satisfaction;Phagocytes;phase change;Physiological;Planet Earth;Poison;Population;potential biomarker;Prevention;Process;psychologic;Puberty;Quality of life;Regulation;Research;Risk;Risk Factors;Role;Schizophrenia;Signal Transduction;single episode major depressive disorder;Site;Sleep;Social Development;spatiotemporal;Structure of choroid plexus;System;Testing;Time;Tissues;Variant;Youth

PROJECT_TITLE: The influence of the developing circadian system on neuroimmune function and neuropsychiatric behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Physical Activity;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative Alcohol-induced skeletal muscle dysfunction affects people with alcohol misuse. Using muscle samples from clinical studies, the proposed work will investigate alcohol-mediated muscle mitochondrial dysfunction and the role of Sirtuin 1 as a contributing factor to decreased bioenergetic capacity. The data generated will serve as mechanistic evidence for targets amenable to lifestyle or therapeutic interventions for improved muscle mitochondrial function.

PI_NAMEs: RODRIGUEZ GRACIANI, KEISHLA MARIE (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acute;Affect;Age;Age Years;Aging;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;ARHGEF5 gene;Basic Science;Bioenergetics;Biogenesis;career;Chronic;chronic alcohol ingestion;Clinical Research;Cryopreservation;Data;Deacetylase;Deacetylation;Dynamin;Electric Stimulation;electrical potential;Energy Metabolism;Ensure;Environment;Ethanol;Exercise;Fluorescence Microscopy;Functional disorder;Funding;Genus Hippocampus;Goals;grasp;Hand;Health;Homeostasis;Human;Impairment;improved;Individual;Intervention;Laboratories;lifestyle intervention;Literature;Maintenance;Measures;Mediating;Membrane Potentials;Mentors;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Muscle;Muscle Fibers;muscle form;Muscle Mitochondria;Myoblasts;Myopathy;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;Older Population;Oxidation-Reduction;Oxidative Stress;Oxygen Consumption;Pathway interactions;Persons;Physical Exercise;Physical Performance;Physiologic pulse;Physiology;Production;protein complex;protein expression;Proteins;Publishing;Reactive Oxygen Species;Research;Research Personnel;Respiration;response;Role;Sampling;Scientist;SIRT1 gene;Sirtuins;Skeletal Muscle;Technology;Testing;Therapeutic Intervention;tissue injury;Training;Transfection;Translational Research;Work

PROJECT_TITLE: Alcohol-mediated mitochondrial adaptations in skeletal muscle: role of Sirtuin1


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Olfactory loss serves as a prodromal symptom of neurodegenerative diseases and is also frequently observed in clinical manifestations among COVID-19 patients. This study aims to characterize and compare the inflammatory responses elicited by neurotoxic oligomers and SARS-CoV-2 infection. Additionally, it seeks to investigate the combined inflammatory responses and their neuropathological implications when viral infection is compounded with predisposing conditions.

PI_NAMEs: GONG, QIZHI  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;alpha synuclein;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Anosmia;Brain;Cell Culture Techniques;cell type;Characteristics;chemokine;Clinical;COVID-19;COVID-19 patient;cytokine;Dementia;disease model;Early Onset Alzheimer Disease;Environment;Event;familial Alzheimer disease;Functional disorder;Genes;glial activation;Human;Immune;Impaired cognition;In Situ Hybridization;Individual;Infection;Inflammation;Inflammatory Response;Innate Immune Response;Investigation;K-18 conjugate;Microglia;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;neurotoxic;Neurotoxins;Nose;novel;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Pathways;olfactory receptor;parent grant;Parkinson Disease;pathogen exposure;Pathology;Phenotype;phosphoneuroprotein 14;post SARS-CoV-2 infection;Prevalence;Process;protein aggregation;receptor expression;Regulation;response;SARS-CoV-2 infection;Signal Transduction;sustentacular cell;Symptoms;Testing;Tissue-Specific Gene Expression;TLR4 gene;Transcript;transcription factor;Viral;Virus Diseases;Virus Replication

PROJECT_TITLE: Investigation of Inflammatory Responses in the Olfactory System


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Amelogenin is essential for enamel formation, and when mutated, it causes X-linked Amelogenesis Imperfecta (X-AI), a hereditary disease that causes enamel defects that decrease the quality of life due to a poor-functioning tooth. This proposal aims to investigate the mechanisms of X-AI development, focusing on how the X-AI-causing mutations affect the key molecular genetics mechanism; alternative splicing of the amelogenin gene. The knowledge outcomes of this study would be utilized to stop or prolong the enamel defect phenotype of this hereditary disease in the future.

PI_NAMEs: SHEMIRANI, ROZANA  (contact)

PROJECT_TERMS: Address;Affect;Alternative Splicing;Amelogenesis Imperfecta;amelogenin;Amino Acids;Appearance;Binding;clinical application;Code;Computer Analysis;crosslink;crosslinking and immunoprecipitation sequencing;Defect;Dental Enamel;Development;disease-causing mutation;doctoral student;Enamel Formation;Enamel Organ;Enhancers;examination questions;Exclusion;Exons;falls;follow-up;Future;Genes;Genetic;Goals;Hereditary Disease;Histologic;Human;Immunoprecipitation;improved;In Vitro;in vivo;Infection;Inherited;Knowledge;laboratory experiment;Link;Messenger RNA;microCT;mineralization;Modeling;Molecular;Molecular Genetics;mouse model;Mutate;Mutation;Oral health;Outcome Study;Pain;Patients;Pattern;Phenotype;Physiological;Play;Process;protein function;Protein Isoforms;Proteins;Publications;Publishing;Quality of life;Regulation;Reporting;Research;RNA Splicing;Role;Severities;Silent Mutation;Site;Spliced Genes;SRSF2 gene;Testing;Tooth structure;Translating;Variant;Western Blotting;Work

PROJECT_TITLE: The molecular mechanism of amelogenin exon4 alternative splicing and its association to amelogenesis imperfecta


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: Narrative This study seeks to elucidate the impact of mild traumatic brain injury (TBI) and alcohol exposure on mitochondrial metabolism during the recovery phase. Additionally, it investigates the potential of alcohol to trigger ferroptosis, a specific cell death process, through mitochondrial pathways in the context of TBI recovery. The research aims to provide insights into the complex interplay between TBI, alcohol, and mitochondrial processes, shedding light on potential mechanisms underlying cellular responses during the recovery period.

PI_NAMEs: CHAPA DUBOCQ, XAVIER RICARDO (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Address;Affect;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol research;Alcoholic Intoxication;Alcohols;Antioxidants;Apoptosis;Arachidonate 15-Lipoxygenase;ARHGEF5 gene;Astrocytes;Behavior;Behavioral;behavioral outcome;Biochemical;Bioenergetics;Biological Markers;Brain;brain metabolism;Cardiac;Cell Death;Cell Death Process;Cessation of life;Cognitive;Cognitive deficits;cognitive function;cognitive recovery;collaborative environment;Collection;comorbidity;comparison control;Complex;Data;disability;Drops;Ensure;Ethanol;extracellular;Female;flexibility;Funding;Genus Hippocampus;Glial Fibrillary Acidic Protein;glucose metabolism;Glutathione;glutathione peroxidase;Growth and Development function;Health;Hour;Immunohistochemistry;Impaired cognition;Impairment;Individual;Inflammation;Injury;insight;Iron;ischemic injury;Knowledge;Laboratories;Lateral;Light;Link;Lipid Peroxidation;Liquid substance;male;Measures;Mentors;Metabolic;Metabolism;mild traumatic brain injury;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neural;neurobehavioral;neuroinflammation;Neurologic;Neurologic Deficit;Neurons;neuropathology;Outcome;Oxidative Stress;Pathway interactions;Pattern;Percussion;Phase;Prefrontal Cortex;Process;Production;Proteins;Publishing;Rattus;Reactive Oxygen Species;receptor;Recovery;Reporting;Research;Research Training;Respiration;response;Risk Factors;Rodent;Role;Sampling;Severities;Short-Term Memory;Signal Transduction;Site;Slice;Structure;TBI Patients;Testing;TFRC gene;Time;tissue injury;Tissues;Training;Translating;Traumatic Brain Injury;Traumatic Brain Injury recovery;vapor;Weight;Work

PROJECT_TITLE: Alcohol Impact on Traumatic Brain Injury: Focus on Mitochondrial Alterations


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Mental Health;Neurosciences

ORG_CITY: HEMPSTEAD

ORG_NAME: HOFSTRA UNIVERSITY

PHR: PROJECT NARRATIVE The symptoms of memory impairment are devastating for patients and families, and existing therapies only have modest efficacy. Devices that implement direct electrical brain stimulation (EBS) hold great promise towards a means of modulating brain function to alleviate memory impairment, but have yielded mixed results, likely due to an incomplete understanding of the mechanisms underlying human memory. The proposed research will implement brain recordings in awake humans to investigate memory neurocircuitry and assess the impact of EBS that is specifically designed to enhance memory-related brain activity, which will lead to improved understanding of the mechanisms underlying human memory and optimized implementation of patient-specific EBS that may ameliorate the symptoms of memory impairment in patients.

PI_NAMEs: MISHRA, AKASH  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: advanced analytics;Age;awake;Behavior;Behavioral;Biological Markers;biomarker identification;Brain;career;Clinical;Coupled;Data;design;Development;Devices;direct application;effective therapy;Electrical Stimulation of the Brain;Electrodes;Electrophysiology (science);Epilepsy;Episodic memory;experience;Family;Foundations;Frequencies;frontal lobe;Goals;Hippocampus;Human;implantation;Implanted Electrodes;improved;in vivo;innovation;Intervention;Intractable Epilepsy;Knowledge;Literature;Location;Measures;Memory;Memory Disorders;memory encoding;Memory impairment;memory recall;memory retrieval;Methodology;Modality;Neocortex;neocortical;neural;neural circuit;neural patterning;Neurodegenerative Disorders;Neurologic;Neurons;neurophysiology;neuroprosthesis;neuropsychiatry;neuroregulation;neurosurgery;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathologic;Patient Recruitments;Patients;Pattern;Performance;Periodicity;Phase;Physicians;Play;Population;Positioning Attribute;pragmatic implementation;Prevalence;Property;Public Health;reduce symptoms;Research;Research Proposals;Resolution;Role;Scientist;Signal Transduction;skill acquisition;spatiotemporal;Specialized Center;Stimulus;Structure;Structure of middle temporal gyrus;Symptoms;Techniques;technological innovation;Training;white matter

PROJECT_TITLE: Determining neural dynamics of human memory using invasive recordings and closed-loop electrical brain stimulation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative Exposure to alcohol in utero predicts future complications with alcohol use and misuse. The proposed study is designed to explore the role of central amygdala neurons that express CRF receptor type I and their projection to the bed nucleus of the stria terminalis as a possible neurobiological mechanism contributing to alcohol misuse in individuals with Fetal Alcohol Spectrum Disorder. This work will expand our current knowledge of prenatal alcohol exposure and CRF system interactions, with the goal of informing novel treatments for individuals prenatally exposed to alcohol.

PI_NAMEs: WINCHESTER, SARAH  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acute;addiction;Adolescent;Adult;Adult women;Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Amygdaloid structure;Animals;Anxiety Disorders;anxiety-related behavior;Behavioral;Brain region;Cell Physiology;Cells;Central Medial Thalamic Nucleus;Cognitive;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;design;Development;early alcohol use;Electrophysiology (science);experimental study;Female;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fos-Related Antigens;Functional disorder;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Immediate-Early Genes;in utero;Individual;Infusion procedures;Knowledge;Link;male;Male Adolescents;Medial;Mediating;Membrane Potentials;Mental Health;Modeling;Mus;negative affect;neural circuit;neuroadaptation;neurobiological mechanism;Neurobiology;neuronal excitability;Neurons;neurophysiology;neurotransmission;novel;Operative Surgical Procedures;optogenetics;patch clamp;Physiology;Population;Pregnancy;Prevalence;Property;Rat Transgene;Rattus;receptor;recruit;Research Design;Rest;Risk;Rodent;Role;sex;Sex Differences;Signal Transduction;Simian virus 40;skills;Slice;Stains;Structure;Structure of terminal stria nuclei of preoptic region;Synapses;synaptic function;System;Testing;Training;transmission process;Viral;Virus;Withdrawal;Woman;Work

PROJECT_TITLE: Prenatal alcohol exposure and acute alcohol: the role of CRFR1 in the extended amygdala


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder is classically characterized by a loss of behavioral control, particularly in the face of negative consequences, resulting in a loss of inhibitory control that may normally suppress alcohol seeking. I hypothesize that a thalamo-striatal circuit, paraventricular thalamus projections to the nucleus accumbens, typically functions to inhibit alcohol seeking but distinct ensembles within this circuit become dysregulated following dependence. Using two-photon microscopy and single-cell optogenetics, I will identify distinct neuronal ensembles in this critical circuit, determine dependence-induced dysregulation, and demonstrate the functional role of these ensembles in regulating alcohol seeking.

PI_NAMEs: WARD, AMY L (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Address;Affect;aged;Alcohol dependence;alcohol exposure;alcohol prevention;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;Attenuated;Behavior Control;Behavioral;behavioral disinhibition;Behavioral inhibition;Calcium;Cells;Chronic;comparison control;Data;Dependence;Development;Disinhibition;Electrophysiology (science);Ethanol;Ethanol dependence;Etiology;experimental study;Glutamates;Head;Image;in vivo;inhibitory neuron;Interneurons;Knowledge;Label;Learning;Measures;motivated behavior;Mus;N-Methylaspartate;National Research Service Awards;neurobiological mechanism;Neurons;novel;Nucleus Accumbens;Optics;optogenetics;Parvalbumins;Pathway interactions;Persons;Population;pre-doctoral;Research;Rewards;Role;Self Administration;Sucrose;Synapses;Testing;Thalamic structure;therapy development;two photon microscopy;two-photon;Work

PROJECT_TITLE: Investigating Ensemble Activity Dynamics of a Thalamo-Striatal Circuit Regulating Alcohol Seeking


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

PHR: PROJECT NARRATIVE The research project described in this proposal aims to enhance our understanding of the neural circuitry that orchestrates avoidance behavior. Using the latest cutting-edge technologies, I will determine how the hippocampal network encodes learned cues that predict aversive outcomes, and how the network uses this information to promote adaptive avoidance behaviors. Given that maladaptive avoidance is relevant to the human anxiety state, these findings could provide direction for future therapeutic interventions.

PI_NAMEs: O'SULLIVAN, RACHEL  (contact)

PROJECT_TERMS: Adaptive Behaviors;Animal Model;Animals;Anterior;Anxiety;Anxiety Disorders;anxiety states;anxiety symptoms;Architecture;Area;avoidance behavior;Avoidance Learning;Behavior;Biological;Biological Assay;biomedical facility;Brain;Brain region;California;Cells;clinical application;conditioned fear;Conflict (Psychology);Cues;Development;Dorsal;Environment;Event;experience;experimental study;Food;Fright;Future;Hippocampus;Human;Imaging technology;Impairment;improved;Individual;innovation;interest;Intervention;Knowledge;Learning;Lesion;Link;Measures;Medical;Memory;memory encoding;Mental disorders;microendoscopy;motivated behavior;Motivation;Mus;Negative Valence;neural;neural circuit;Neurosciences;optogenetics;Outcome;Patients;Performance;Phase;Phenotype;Phylogeny;Play;Population;Population Projection;Positioning Attribute;Predatory Behavior;Prevalence;Process;Property;psychologic;Quality of life;reduce symptoms;Reporting;Research;Research Project Grants;Research Support;Resolution;response;Rodent;Role;San Francisco;Scientist;Shock;Signal Transduction;Stimulus;Structure;Techniques;Technology;Testing;Therapeutic Intervention;therapeutically effective;tool;Training;United States;Universities;Viral Vector;Work

PROJECT_TITLE: Understanding the mechanisms by which vCA1 orchestrates avoidance behavior


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Clinically Assessed Risk Factors for a Second ACL Injury Using an Innovative Wearable Sensor Project Narrative ACL injuries are common among adolescent athletes, and due to residual muscle weakness and asymmetrical movement and loading patterns, many sustain a second ACL injury following return to unrestricted physical activity. This clinical cohort study seeks to demonstrate that a combination of traditional clinical and novel clinical return to sport measures (including load symmetry) will result in high predictive accuracy for second ACL injuries. The project specifically focuses on assessing the role that novel clinical return to sport measures (load asymmetry, a known risk factor for ACL re-injury) have in predicting second ACL injuries and will result in the development of a clinic based prognostic model that can be used in return to sport decision-making.

PI_NAMEs: QUEEN, ROBIN M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academy;Address;Adolescent;American;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Behavioral;Bilateral;Caring;Characteristics;Clinic;Clinical;Clinical assessments;clinical care;clinically relevant;Cohort Studies;Consensus;Contralateral;cost;Data;Data Collection;Decision Making;Development;Equipment;evidence base;Failure;Fright;Future;Goals;graft failure;Guidelines;high risk;improved;Incidence;indexing;Individual;injured;Injury;injury surveillance;innovation;instrument;Intervention;Laboratories;Limb structure;Lower Extremity;Measurement;Measures;Methods;model development;modifiable risk;Motion;Movement;Multicenter Studies;muscle strength;Muscle Weakness;neuromuscular;novel;Observational Study;Orthopedics;Outcome;Patients;Pattern;Performance;Physical activity;Physicians;Play;Postoperative Period;premature;prognostic model;psychologic;Randomized;Readiness;reconstruction;recruit;Rehabilitation therapy;Reporting;Research;residual limb;Residual state;restoration;return to sport;Risk;Risk Factors;Role;Running;sensor;Shoes;Speed;Sports;standard of care;Surgeon;Testing;Time;Validation;Walking;wearable sensor technology

PROJECT_TITLE: Clinically Assessed Risk Factors for a Second ACL Injury Using an Innovative Wearable Sensor – Diversity Supplement

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]