ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The incidence of invasive cervical cancer (ICC) is considerably higher in women living with HIV (WLWH) compared to women living without HIV. Toll-like receptors (TLR) agonists show promise for dysplasia therapy, but the relationship of TLR expression in WLWH with cervical cancer is unknown. Here we will evaluate TLR expression in WLWH and without HIV with cervical cancer, in a diverse population of African and African American women and test a novel TLR agonist formulation in animal models to determine how it affects immunity and progression of cervical cancer.

PI_NAMEs: SCHWARTZ, GARY K (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Africa;Africa South of the Sahara;African;African American Women;Agonist;AIDS related cancer;Animal Model;Area;Asia;Atopobium vaginae;Benign;Biological;Biopsy;Cancer Center Support Grant;cancer health disparity;cancer therapy;Cells;Cervical;Cervical dysplasia;Cervix Uteri;Clinical;cohort;Comprehensive Cancer Center;cost;Data;density;Development;differential expression;Disease;Disease Progression;dysbiosis;Dysplasia;Europe;Experimental Models;Formulation;Health;high risk;HIV;HIV Infections;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;Immunity;Immunohistochemistry;Immunotherapy;improved;In Situ Hybridization;in vivo;Incidence;Infection;Inflammatory;Innate Immune System;insight;Lesion;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;manufacture;marginalization;Medical;member;Metabolic Pathway;microbial community;Morbidity - disease rate;mouse model;Mucous Membrane;Mus;novel;novel therapeutic intervention;Papillomavirus;Pathway interactions;Patients;Performance;Population Heterogeneity;Primary Prevention;protein expression;Proteome;Quantitative Reverse Transcriptase PCR;receptor;receptor density;receptor expression;Research;Resource-limited setting;response;Role;screening;screening program;Secondary Prevention;side effect;Signal Transduction;South America;Technology;Testing;Therapeutic;Time;Tissues;TLR7 gene;Toll-Like Receptor Pathway;Toll-like receptors;Topical application;Toxic effect;transcriptome sequencing;Treatment Efficacy;Treatment Protocols;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Uganda;United States;Vaccinated;Vaccines;Vagina;vaginal microbiome;vaginal microbiota;Vaginal Route of Drug Administration;Viral Proteins;Woman;Work

PROJECT_TITLE: Case Comprehensive Cancer Center Support Grant


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative This project will examine how experiences of microaggressions, a common and understudied form of racial discrimination, affect Black youth’s neurobiological vigilance circuitry, and subsequent PTSD symptoms several months after a traumatic assault. The results of the study will highlight both the immediate effect of experiencing microaggressions as well as the impact of cumulative experiences during the first year of recovery from a traumatic assault. Results may suggest a mechanism linking experiences of racial microaggressions to posttraumatic stress symptoms, and thus, inform a target for intervention that considers Black youth’s lived experiences with racial discrimination as they intersect with additional traumatic events.

PI_NAMEs: HARB, FARAH  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 16 year old;7 year old;Accident and Emergency department;Accounting;Acute;Adolescence;Adult;Affect;Age;aged;alertness;Amygdaloid structure;Anterior;Anxiety;assault;Basic Science;Biological;Black race;Brain;brain health;Brain region;Child;cingulate cortex;Data;depressive symptoms;Detection;Development;Discrimination;Dorsal;emotion regulation;experience;Exposure to;follow-up;Frequencies;Fright;functional MRI scan;Future;Individual;innovation;Intervention;Investigation;Link;Lived experience;Long-Term Effects;Mediating;Mediation;Mental Depression;Mental Health;Methodology;microaggression;Modeling;Nature;neural;Neurobiology;neuroimaging;Outcome;Parents;Participant;Patient Self-Report;post-trauma;Post-Traumatic Stress Disorders;post-traumatic symptoms;Process;psychologic;Psychological Impact;Psychopathology;Questionnaires;Race;racial discrimination;racism;Recovery;recruit;Regression Analysis;Reporting;Research;Rest;Risk;Risk Factors;Role;Sampling;Scanning;Severities;Shapes;Structure;Symptoms;Thalamic structure;Time;Trauma;trauma centers;trauma exposure;Trauma recovery;traumatic event;United States National Institutes of Health;Victimization;vigilance;Violence;Visit;Wisconsin;Youth

PROJECT_TITLE: Racial Microaggressions, Neural Vigilance Circuitry and PTSD Outcomes in Youth Victims of Violence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project narrative People living with HIV (PWH) at the age of 50 or older have a higher incidence of cancers and worse outcomes than those without HIV infection. To improve treatment and health of older PWH, we must better understand the molecular and cellular mechanisms by which HIV infection and aging facilitate cancer development among PWH. Our proposed interdisciplinary studies using immune cells from older PWH will help decipher how HIV-associated cancers and aging affect host gene expression and the innate immunity.

PI_NAMEs: BURKARD, MARK E (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;Affect;Age;Aging;AIDS related cancer;antiretroviral therapy;Cancer Patient;cancer therapy;cancer type;Cell Aging;Cells;Characteristics;Chronic;Clinical;design;Development;diagnostic biomarker;Enzyme-Linked Immunosorbent Assay;Exhibits;Foundations;Gene Expression;Genes;Goals;Health;HIV;HIV Infections;HIV-1;Human;Immune;immune activation;Immunity;Immunologics;Impairment;improved;In Vitro;Incidence;Individual;Infection;Interdisciplinary Study;Interferon Type I;Interferons;Malignant Neoplasms;Measures;Messenger RNA;Modification;Molecular;monocyte;mRNA Expression;Natural Immunity;novel;Older Population;Outcome;Patients;peripheral blood;Persons;Play;Population;predictive marker;Prognostic Marker;Reporting;response;RNA;Role;Sampling;Testing;transcriptome sequencing

PROJECT_TITLE: Exploring m6A RNA Modification in HIV-associated Cancers in Aging Populations (HIV-Associated Cancers in Aging Populations)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Computational models suggest cognitive deficits in schizophrenia (SZ) may arise from the effects of cortical excitation:inhibition (E:I) balance disruptions in regions of the association cortex. These models have computational and statistical properties that make them difficult to translate to clinically relevant contexts. The proposed project uses a novel computational approach, Mesoscale Individualized Neurodynamic (MINDy) modeling, to translate computational models of E:I balance to large-scale neuroimaging datasets, genetically- informative research designs, and novel asessments of cognitive function in schizophrenia.

PI_NAMEs: PINE, JACOB  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adolescent;Area;association cortex;Autopsy;Biological;biophysical properties;Biophysics;Brain;causal model;Clinical;clinically relevant;Cognitive deficits;cognitive development;cognitive enhancement;cognitive function;computer framework;Computer Models;connectome;cost;Data;Data Set;Decision Making;Diffusion;Disabling;Dizygotic Twins;early psychosis;economic cost;Environment;Equilibrium;FDA approved;Form Perception;Functional Magnetic Resonance Imaging;Future;Gene Expression;generative models;Genetic;Genetic Variation;Goals;Heritability;human data;Impairment;improved;Individual;Individual Differences;innovation;interest;Investigation;Link;Measures;member;Memory impairment;Modeling;Monozygotic twins;National Research Service Awards;Neocortex;neural;neuroimaging;neurophysiology;Neurosciences;nonhuman primate;novel;Outcome Measure;Patients;Pattern;Pharmaceutical Preparations;Population;Prefrontal Cortex;prevent;Property;Proxy;Psychometrics;Psychoses;Randomized, Controlled Trials;Recurrence;Research Design;Rest;Rodent;Sampling;Schizophrenia;Sensory;sensory cortex;Short-Term Memory;Source;Sum;Symptoms;Techniques;Testing;Theoretical model;theories;Therapeutic;therapy development;Time;Tissues;Training;Translating;translational neuroscience;Twin Studies;Work

PROJECT_TITLE: Generative Modeling of Excitation:Inhibition Balance Abnormalities in Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE We propose a novel computational framework for clinical investigators to initiate clinical trial simulation studies using real world data (RWD). We propose a first-of-its-kind computational approach to represent the entirety of Alzheimer’s disease (AD) trials while considering the connection of RWD (Aim 1), to use both structured and unstructured RWD to develop robust phenotyping algorithms that will render previously incomputable AD study traits computable (Aim 2), and to develop a web application which will provide an integrated environment for AD researchers to construct virtual AD trials using an interactive web interface and obtain analytic-ready datasets for trial simulation studies (Aim 3).

PI_NAMEs: BIAN, JIANG ;TAO, CUI  (contact);ZHANG, GUO-QIANG

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Address;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;biomedical ontology;Brain Diseases;Caregiver Burden;Case Study;Cause of Death;Characteristics;Clinical;Clinical Data;Clinical Investigator;clinical practice;Clinical Trials;Clinical Trials Design;Cognitive;Cohort Studies;Collection;Communities;compare effectiveness;computable phenotypes;computer framework;Computing Methodologies;Controlled Environment;cost;Data;data modeling;Data Science;Data Set;data standards;database query;Dementia;design;Development;Disease;drug repurposing;effective therapy;Effectiveness;Effectiveness of Interventions;Electronic Health Record;Eligibility Determination;Ensure;Environment;Evaluation;follow-up;improved;Informatics;interoperability;Learning;Medical;Medicine;Memory Loss;Metadata;Methodology;Methods;Modeling;Natural Language Processing;Nerve Degeneration;Nervous System Disorder;novel;Online Systems;Ontology;open source;Outcome;Outcome Measure;outreach;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;phenotyping algorithm;Physicians;pilot test;Population;post-market;Process;Protocols documentation;prototype;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reproducibility;Research;Research Design;Research Personnel;Resources;Safety;Signal Transduction;simulation;Societies;Standardization;Structure;study population;success;Symptoms;System;Testing;Time;tool;trait;Translating;trial design;United States;unstructured data;usability;virtual;web app;web interface;Work

PROJECT_TITLE: ACTS (AD Clinical Trial Simulation): Developing Advanced Informatics Approaches for an Alzheimer's Disease Clinical Trial Simulation System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE People living with HIV are more susceptible to developing multiple types of cancer, particularly B-cell lymphomas (BCLs). With the use of humanized mice as a model for HIV infection, we aim to assess and fine- tune our novel approaches to BCL treatment within the context of the human immune system.

PI_NAMEs: SLECKMAN, BARRY P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Aging;Animals;anti-cancer treatment;anticancer activity;Antigens;antiretroviral therapy;B-Cell Activation;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;bioimaging;Bioluminescence;Blood;Blood Cells;Burkitt Lymphoma;Cancer Center Support Grant;Cancer Control;cancer immunotherapy;cancer risk;cancer therapy;cancer type;CAR T cell therapy;carcinogenesis;CD4 Positive T Lymphocytes;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;clinical practice;co-infection;combinatorial;comorbidity;Comprehensive Cancer Center;Development;Effectiveness;effectiveness evaluation;Engineering;Epstein-Barr Virus Infections;Evaluation;Exhibits;experimental study;Face;General Population;Genes;Growth;high risk;HIV;HIV Infections;Human;humanized mouse;immune function;Immune response;Immune system;Immunologic Monitoring;Immunologics;Immunotherapeutic agent;Immunotherapy;Impairment;improved;in vivo;in vivo Model;Individual;Infection;Infusion procedures;innovation;knock-down;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Maintenance;Malignant Neoplasms;manufacture;MAPK8 gene;Mediating;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;N-terminal;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;novel strategies;Older Population;peripheral blood;Persons;Phenotype;Phosphotransferases;Population;Predisposition;Production;Property;Proteins;Proviruses;Risk;Role;self-renewal;small hairpin RNA;stemness;Study models;success;Supporting Cell;Survival Rate;System;T-Lymphocyte;Testing;Tissues;trait;transcriptomics;treatment and outcome;trend;tumor microenvironment;tumor-immune system interactions;United States;vector;Virus;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Wound Healing and Care

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Since 1979, the biennial Gordon Research Conference on Epithelial Differentiation and Keratinization (GRC- EDK) and its associated, trainee-run Gordon Research Seminar on Epithelial Differentiation and Keratinization (GRS-EDK) have served as a pivotal platform to showcase the latest conceptual and technological advances aimed at addressing fundamental questions in epithelial biology and to advance scientific discoveries into treatments for human disease. The 2025 GRC/GRS-EDK will focus on areas such as stem cells and homeostasis, epithelial tissue organization and niche signaling, immunology, epigenomics, cutting-edge technologies, and innovative therapeutic approaches. The 2025 GRC/GRS-EDK meetings aim to present breakthrough discoveries in these fields, encourage the free exchange of ideas, facilitate interactions and new collaborations, and promote discussions on enhancing diversity and inclusion in the scientific community.

PI_NAMEs: EZHKOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Academia;acute wound;Address;Advertising;Aging;Ambystoma;Architecture;Area;Attention;Biological Models;Biology;blind;California;Cancer Detection;cancer therapy;career;Career Choice;career development;Cell Communication;Cells;chronic wound;clinical practice;Collaborations;Communities;Development;Discrimination;Disease;diversity and inclusion;Economic Burden;Ensure;Epigenetic Process;epigenomics;Epithelium;Ethnic Origin;Faculty;Female;Fibroblasts;Fibrosis;Fostering;Future;Genomics;Geographic Locations;Homeostasis;Hour;Human;human disease;Immune;Immune System Diseases;Immunity;Immunology;improved;Industry;innovation;innovative technologies;International;Japan;keratinization;Light;Location;male;Malignant Neoplasms;Medical;meetings;men;Mentors;model organism;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;next generation;novel;novel therapeutics;Organoids;Participant;Pemphigus;programs;Regenerative Medicine;Research;Research Personnel;Running;Salamander;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Shapes;Signal Transduction;Skin;skin disorder;skin regeneration;stem cell biology;stem cells;Stress;supportive environment;symposium;System;Technology;Therapeutic;Time;Tissues;transcriptomics;Translating;Voting;Woman;wound healing

PROJECT_TITLE: 2025 Epithelial Differentiation and Keratinization Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Suicide;Suicide Prevention;Violence Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Suicide and overdose are leading causes of death for people released from prison and there are strong racialized disparities in these health outcomes. Through this proposed plan, the applicant will use advanced epidemiologic approaches to optimize North Carolina’s post-release supervision (PRS) program to prevent and address racialized disparities in suicide and overdose mortality and reincarceration among formerly incarcerated people. This work will generate evidence-based policy-relevant PRS recommendations to support community reentry for people being released from prisons.

PI_NAMEs: SWILLEY-MARTINEZ, MONICA E (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Acclimatization;Address;administrative database;Affect;Algorithms;Back;Black Populations;career;Cause of Death;Characteristics;Communities;community reentry;Data;Data Set;Death Records;Employment;Epidemiologic Methods;Epidemiologist;Epidemiology;Ethnic Origin;evidence base;evidence based guidelines;experience;Future;General Population;Goals;Guidelines;health care referral;health disparity;health inequalities;Hispanic Populations;Imprisonment;improved;improved outcome;Incidence;Individual;Injury;Institutional Racism;Intervention;Knowledge;Legal system;Length;Life;Link;Logistic Regressions;longitudinal analysis;Mental Health;Methods;mortality;mortality risk;National Institute on Minority Health and Health Disparities;North Carolina;novel;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;parole;Persons;Pharmaceutical Preparations;Phase;Policies;policy recommendation;population based;Populations at Risk;Predisposition;prevent;preventive intervention;Prisons;Probability;probation;Process;programs;Race;racial disparity;Racial Equity;racial health disparity;racial minority;racial minority population;racial population;racism;Recommendation;Records;reducing suicide;referral services;Rehabilitation therapy;reincarceration;Research;Research Personnel;Risk;Risk Estimate;Risk Reduction;Role;Severities;skills;social;substance use treatment;suicidal morbidity;suicidal risk;Suicide;suicide mortality;Suicide prevention;suicide rate;Supervision;supported housing;Training;Vision;Work

PROJECT_TITLE: Developing Racially Equitable post-release  supervision Assignment guidelines to prevent overdose and suicide Mortality among formerly incarcerated people (DREAM)


NIH_SPENDING_CATS: Aging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE The proposed study will examine two biomarkers of aging (immune cell profile and biological aging) derived from tissue specific DNA methylation patterns and their correlations in normal and pre-cancer tissues to evaluate differences in cervical pre-cancer lesions development and progression. The study will also compare patterns between women living with HIV and without HIV among two races (White and Black).

PROJECT_TERMS: 11 year old;Acquired Immunodeficiency Syndrome;Address;Adult;Age;age acceleration;age group;age related biomarkers;Aging;aging biomarker;aging related;Algorithms;Anatomy;Archives;Automobile Driving;Biological;biological age;Biological Aging;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biology;biomarker identification;Black race;Cancer Biology;Cancer Center Support Grant;cancer classification;cancer diagnosis;Cancer Etiology;cancer risk;cancer type;Carcinogens;Cell Separation;Cells;Cervical;Cervical Squamous Cell Carcinoma;Cessation of life;Chronology;Comprehensive Cancer Center;Computational algorithm;Country;demethylation;design;design verification;Deterioration;Development;Disease;DNA Methylation;Early Diagnosis;early onset;Environment;Epidemiologist;Epigenetic age;Epigenetic Process;epigenomics;Epithelium;Ethnic Population;Event;experimental study;Female;Formalin;General Population;genetic risk factor;Goals;graduate student;Gynecology;hallmarks of aging;high risk population;HIV;HIV Infections;HIV Seronegativity;HPV oropharyngeal cancer;HPV-High Risk;human old age (65+);Human papilloma virus infection;Human Papillomavirus;Immune;Immune system;Immunosuppression;Impairment;Incidence;Income;Individual;Inflammation;innovation;insight;International Agency for Research on Cancer;intraepithelial;Knowledge;Lesion;Leukocytes;Low risk HPV;Lymphocyte;Malignant neoplasm of cervix uteri;Malignant Neoplasms;marginalized population;Mentors;Methylation;methylation pattern;Minority Groups;Molecular;Molecular Biology;monocyte;Morbidity - disease rate;mortality;neoplastic;neutrophil;Nucleotides;Oncologist;Paraffin Embedding;Pathogenesis;Pattern;premalignant;Prevention strategy;Race;racial population;Reporting;Research;Research Design;Research Personnel;research study;Risk;Role;Sampling;Squamous intraepithelial lesion;systemic inflammatory response;Techniques;Technology;therapeutic vaccine;Time;Tissues;Translating;transmission process;trend;vaccine development;Validation;Vulnerable Populations;Woman


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Herpesviruses are important human pathogens that can have devastating effects in neonates and immunocompromised individuals, yet there is no cure for any herpesvirus and treatment options are lacking. Here, I dissect the mechanism of an essential feature of the herpesviral lifecycle - viral genome packaging - by exploring the role of a unique accessory factor required for packaging and by developing an assay to monitor packaging in vitro. Detailed mechanistic insight is essential to understand the mechanism of current antiherpesviral drugs and to facilitate the identification of new targets for antivirals.

PI_NAMEs: DIDYCHUK, ALLISON LOUISE (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Adopted;Africa South of the Sahara;Anti-viral Agents;Area;Award;Bacteriophages;Behavior;Biochemical;Biochemistry;Biological Assay;Biology;biophysical properties;Biophysics;Cancer Etiology;Capsid;Charge;Complex;Congenital Abnormality;Coupled;Development;Disease;Dissection;DNA Viruses;drug discovery;Drug Targeting;Evolution;FDA approved;Foundations;Genome;Goals;Herpes encephalitis;Herpes Labialis;Herpesviridae;High Prevalence;high reward;high risk;HIV;Homologous Gene;Human;Human Herpesvirus 8;human pathogen;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;inhibitor;insight;interest;Investments;Kaposi Sarcoma;Label;Life;Life Cycle Stages;Malignant Neoplasms;Mass Spectrum Analysis;Methodology;Methods;Microscopy;Molecular;Molecular Motors;Molecular Virology;Monitor;Motor;Mutagenesis;mutation screening;neonate;new therapeutic target;novel;Nucleic Acid Binding;Oncogenic;pathogen;Pharmaceutical Preparations;Positioning Attribute;Process;programs;Proteins;Proteomics;reconstitution;Regulation;Research Personnel;resistance mutation;Resources;Role;scaffold;structural biology;Structure;success;System;Tail;Techniques;terminase;Testing;Time;Viral;Viral Genome;Viral Packaging;Viral Proteins;virology;Virus;Virus Replication;Vision;Work

PROJECT_TITLE: Dissecting the mechanism of herpesvirus genome packaging


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Vancomycin is the most important drug for C. difficile infection (CDI). This study investigates vancomycin resistance mechanisms in C. difficile and their clinical impact, as well was researches alternate treatments. Project Narrative

PI_NAMEs: GAREY, KEVIN W;HURDLE, JULIAN G (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Affect;Antibiotic Resistance;Antibiotics;Autolysis;Back;Binding;biobank;Biochemistry;Bioinformatics;Biological;Biology;Bioreactors;Cell Wall;Cessation of life;Characteristics;Clinical;Clinical Data;clinical efficacy;clinical practice;Clinical Research;Clostridium difficile;Collection;Colon;cost;Data;Decision Making;Diagnosis;Diagnostic;disabled;Disease;Disease Outbreaks;Dose;Drug resistance;Economic Burden;emerging pathogen;Epidemic;Epidemiology;epidemiology study;Evolution;Failure;FDA approved;fluoroquinolone resistance;Fluoroquinolones;Foundations;Genetic;Genetic Programming;genetic signature;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome wide association study;Genomics;Glycopeptides;Goals;Hamsters;high risk;Hospitals;Impairment;improved;In Vitro;Infection;infection risk;International;Investigation;Lipid Binding;Lipids;Metadata;Metronidazole;Metronidazole resistance;Microbial Genetics;microbiome;microbiota;minimal risk;Modeling;Molecular;molecular diagnostics;Molecular Epidemiology;Molecular Genetics;Morbidity - disease rate;mortality;Mus;mutant;Mutate;Nitroreductases;Operon;Organism;Osmoregulation;Outcome;Outcomes Research;Pathologic;Patient Isolation;Patient-Focused Outcomes;Patients;Pattern;Periodicity;Pharmaceutical Preparations;pharmacologic;phenotypic data;phosphoric diester hydrolase;Physiological;population based;Population Genetics;preclinical study;Predisposition;pressure;Prevalence;Public Health;rapid detection;Recurrence;Reporting;Research;Resistance;Resistance development;resistance mechanism;resistant strain;response;Risk;Sampling;Science;Selection for Treatments;Severity of illness;Systems Biology;telavancin;Testing;Therapeutic;trait;transmission process;Treatment Failure;treatment response;United States;Validation;Vancomycin;Vancomycin Resistance

PROJECT_TITLE: Diversity Supplement: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Contact PD/PI: Mead, Erin Lucia PROJECT NARRATIVE The dual use of little cigars/cigarillos (LCCs) and cigarettes is a significant public health concern for young adults' health and tobacco addiction. Among young adult dual users, this study compares the addiction potential of LCCs to cigarettes and determines if flavors enhance the addiction and if women are especially susceptible. Results can be used to better inform LCC regulation and cessation programs for this high-priority population. Page 7 Project Narrative

PI_NAMEs: MEAD-MORSE, ERIN LUCIA (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: addiction;addiction liability;Affective;Award;Behavior;Behavioral;behavioral economics;Biological Markers;career;career development;Characteristics;Cigar;Cigarette;cigarette smoking;cigarillos;Clinical Trials;Cognitive;Computer software;Consumption;cost;Crossover Design;Data;Data Collection;Dependence;Development;Development Plans;Disease;Ecological momentary assessment;economic evaluation;Equipment;Event;experience;Faculty;Flavoring;Goals;Grant;Health;Home;Home environment;indexing;innovation;Life;Measurement;Measures;men;Mentors;Methods;Play;Population;Predisposition;Price;programs;Public Health;Regulation;Research;Research Personnel;Resources;Role;Scientist;sex;Sex Differences;standardize measure;Surveys;Tobacco;Tobacco Dependence;tobacco products;tobacco regulation;Tobacco use;Training;uptake;Vulnerable Populations;Woman;Writing;young adult

PROJECT_TITLE: Impact of Cigar Flavor in Dual Users: Critical Life Event Supplement


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative  Hallucinations and other perceptual abnormalities are hallmark symptoms of psychosis spectrum disorders, but as of yet, there is no definitive mechanism to target for intervention and prevention. One modern theory of hallucination formation leverages a predictive coding model of belief updating, but this model might be expanded upon by considering the mechanisms driving the vividness of mental imagery to explain perceptual abnormality severity. By combining the predictive coding theory with novel research on the mechanisms of mental imagery, the present study aims to identify a potential mechanism for the formation of perceptual abnormalities and thus identifying a target for intervention.

PI_NAMEs: PRATT, DANIELLE N (contact)

PROJECT_TITLE: The Role of Mental Imagery in Perceptual Abnormality Formation in Individuals at Clinical High-Risk for Psychosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: 1.1 Project Narrative: Overall The mission of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) is to undertake innovative basic and clinical and population research that will impact the understanding and treatment of cancer around the world and to provide state-of-the-art clinical care to cancer patients in Maryland and beyond.

PI_NAMEs: OWONIKOKO, TAOFEEK K (contact)

PROJECT_TERMS: Adjuvant Therapy;Age;Age related comorbidities;Age Years;Aging;AIDS related cancer;AIDS-Related Lymphoma;Animal Model;Antibodies;Antigens;antiretroviral therapy;Archives;Basic Science;Blood;Blood specimen;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Communication;cell growth;Cell Line;chemotherapy;Chronic;clinical care;Clinical Research;comorbidity;Comprehensive Cancer Center;cytokine;cytotoxic;Data;Disease remission;effector T cell;Enrollment;Experimental Models;Functional disorder;Future;Goals;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Hodgkin Disease;Human;humanized mouse;Immune;immune activation;immune checkpoint;Immune System Diseases;Immunohistochemistry;In Vitro;in vivo;Individual;Inflammation;innovation;Life Expectancy;life span;Link;Lymphocyte;Lymphoma;Lymphoma cell;Malignant Neoplasms;Maryland;Measures;Mission;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;Nicotinamide adenine dinucleotide;nicotinamide-beta-riboside;Non-Hodgkin's Lymphoma;Older Population;overexpression;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;Population Research;prevent;Prevention strategy;Production;protein expression;Proteins;Publishing;Research Priority;Risk;T-Lymphocyte;targeted cancer therapy;Testing;Therapeutic;Tissue Sample;Toxic effect;treatment strategy;tumor growth;Tumor Markers;Tumor Promotion;United States;United States National Institutes of Health;Universities;Viral;Virus;Xenograft procedure

PROJECT_TITLE: Targeting CD38 in HIV-associated Lymphoma


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Urologic Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Highly targeted nerve stimulation could greatly benefit people with lower urinary tract disease by correcting the behavior of malfunctioning organs; however, the urinary tract has so many complex, interacting parts that tuning all the stimulation parameters accurately to get good therapy is very difficult. We propose a new framework for computationally modeling the lower urinary tract that combines mathematical models of known physiological principles with unknown complexities accounted for by artificial intelligence. Drawing on this framework, we can simulate the urinary tract, and innumerable possible nerve stimulations, to learn more about what goes wrong in urinary tract disease and discover the most promising therapies.

PI_NAMEs: DANZIGER, ZACHARY C (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: age related;aged;Anesthesia procedures;Animal Model;Animals;Artificial Intelligence;artificial neural network;Behavior;Biological;biophysical model;Biophysics;Bladder;candidate identification;Clinical;cohort;Complex;computer framework;Computer Models;Computer Simulation;Consumption;cost;Data;Data Set;deep learning;deep neural network;design;Development;Differential Equation;Disease;effective therapy;Ensure;Etiology;experimental study;Functional disorder;Generations;Goals;Hybrids;in vivo;insight;Intervention;intervention effect;Intervention Studies;invention;Knowledge;Learning;learning network;Link;Lower urinary tract;mathematical model;Measurement;Measures;Methods;model generalizability;Modeling;Nerve;nerve transection;neural;neural network;Neuroanatomy;neuroregulation;novel;Organ;Outcome;Output;Peripheral;Peripheral Nerves;Persons;Physiological;Physiology;predictive modeling;Process;Rattus;Reflex action;Reflex control;response;Sensory;Series;Severities;side effect;simulation;Site;Source;standard care;Structure;Symptoms;Syndrome;System;Testing;theories;Therapeutic;Time;Tissues;tool;Training;training data;treatment optimization;Uncertainty;Update;Urethra;Urinary tract;Urinary Tract Physiology;Urologic Diseases;Validation;Weight;Work

PROJECT_TITLE: A new hybrid modeling framework combining biophysics and deep learning to predict and optimize peripheral neuromodulation outcomes in lower urinary tract  disease

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Defects in cellular polarity are associated with numerous neurological disorders, kidney diseases, and cancer. In many cell types, polarity is established by the motor-driven localization of RNAs, proteins and vesicles to distinct regions within the cell. This proposal seeks to understand the molecular mechanism by which cell polarity is established and the role of motor proteins in this process.

PI_NAMEs: GONSALVEZ, GRAYDON  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Binding Proteins;Biochemical;Biotin;Cell Polarity;cell type;Cells;Complex;Coupled;Defect;developmental disease;Drosophila melanogaster;egg;Embryo;Epithelium;falls;fly;Human;Kidney Diseases;Knowledge;Life;Ligation;Link;Maintenance;Malignant Neoplasms;Mammals;messenger ribonucleoprotein;Messenger RNA;Modeling;Molecular;Molecular Motors;Motor;Nature;Nervous System Disorder;Neurons;novel strategies;Organelles;Organism;particle;Prevalence;Process;protein complex;Protein Sortings;Proteins;RNA;RNA-Protein Interaction;Role;Site;Structure;Testing;Translational Regulation;Translations;Vesicle;Yeasts

PROJECT_TITLE: Molecular mechanisms underlying the establishment of cell polarity.

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Synaptic connections in the hippocampus have exquisite dynamic properties which underlie plasticity and cognition in the brain. Elucidating the mechanisms that regulate synaptic behavior is therefore key to understanding deficits in cognition and memory that contribute to neurodevelopmental and neurological disorders. In this project, I will determine how Ca2+ sensor molecules underlie the activity dependent dynamics of synapses and thus regulate hippocampal circuits that drive cognition.

PI_NAMEs: BARRAZA, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Action Potentials;Address;Affect;Affinity;Anatomy;Area;Axon;Behavior;Binding;Biochemical;Brain;Brain region;C2 Domain;Cell membrane;Cells;Cognition;complement C2a;complement C2b;Complex;conditional knockout;Coupling;dentate gyrus;Excitatory Postsynaptic Potentials;Exhibits;Exocytosis;experimental study;Fellowship;Fractionation;Frequencies;Future;Genetic;Glutamates;Goals;granule cell;Hippocampal Mossy Fibers;Hippocampus;Impairment;In Situ;Individual;Interneurons;Knock-out;knockout animal;Knockout Mice;Location;Mediating;Membrane;Memory;Microscopy;Molecular;mossy fiber;mutant;nanoscale;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;neurotransmitter release;novel;Optics;patch clamp;Pattern;Phenotype;postsynaptic;presynaptic;Presynaptic Terminals;Probability;Process;Property;Proteins;Pyramidal Cells;Recycling;Research;Resolution;Role;sensor;Slice;Space Perception;Stratum Lucidum;Synapses;Synaptic plasticity;Synaptic Vesicles;synaptotagmin I;synaptotagmin VII;Testing;Tissue Expansion;ultra high resolution;Vesicle;Viral;Work

PROJECT_TITLE: Synaptotagmin 7: A compartmentalized molecule for presynaptic short term plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: BARIC, RALPH  (contact)

PROJECT_TERMS: Biological Models;Biological Products;Contracts;Coronavirus;coronavirus vaccine;Development;Evaluation;immunogenicity;infectious disease model;Mus;technology platform;vaccine development;vaccine evaluation

PROJECT_TITLE: Task A68: Screening Vaccine (and Other Biologics) Platform Technologies using Coronavirus Mouse Immunogenicity as a Model System


NIH_SPENDING_CATS: Aging

ORG_CITY: MADISON

ORG_NAME: CLEMETRIC, LLC

PI_NAMEs: POLYNICE, GERGENS  (contact)

PROJECT_TERMS: Aging;Databases;Primates

PROJECT_TITLE: MANAGEMENT OF THE PRIMATE AGING DATABASE


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

PHR: PROJECT NARRATIVE Prenatal Alcohol Exposure (PAE) is the leading cause of neurodevelopmental disability in the US. However, the emerging practice of simultaneous alcohol and cannabinoid (SAC) use among young adults of child-bearing age makes it imperitive to investigate the additional risk for adverse infant outcomes due to such prenatal poly-substance use. The goals of this proposal are consistent with the priorities of the Collaborative Research on Addiction at NIH (CRAN) initiative, which are to, “address poly- or multiple substance use, abuse, and addiction” and to “elucidate the common, specific, and interacting causes and consequences of substance exposure”.

PI_NAMEs: LARIN, KIRILL V;MIRANDA, RAJESH C (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acute;addiction;Address;Adolescent;Adult;Age;Alcohol consumption;alcohol exposure;Alcohols;Anatomy;angiogenesis;Angiogenesis Inhibition;Behavior;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Birth;Blood flow;blood vessel development;Brain;brain based;brain size;cannabinoid receptor;cannabinoid receptor antagonist;Cannabinoids;Cells;cerebrovascular;Cerebrovascular Circulation;child bearing;conditioned place preference;Consumption;craniofacial;Data;Defect;Development;Developmental Disabilities;disability;Dose;Drug usage;efficacy evaluation;Ethanol;Exposure to;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Development;Fetus;Goals;Growth;Histologic;Human;Hyperactivity;Impairment;in vivo;indexing;infant outcome;Ingestion;innovation;Intervention;Intoxication;Label;Legal;Light;Literature;malformation;marijuana legalization;marijuana use;Maternal Exposure;Mediating;Microscopy;Modeling;Molecular;Molecular Analysis;mouse model;multiple drug use;Mus;nerve stem cell;neural;Neurodevelopmental Disability;neurogenesis;neurovascular;novel;offspring;Optical Coherence Tomography;optical imaging;Outcome;Outcome Study;Pharmaceutical Preparations;pharmacologic;Placenta;polysubstance use;Positioning Attribute;preference;Pregnancy Outcome;prenatal;prevent;protective effect;psychologic;Public Policy;Publishing;Receptor Activation;Recreation;Reporter;Reporting;Research;Resolution;Risk;Risk Taking;Rodent;Second Pregnancy Trimester;Severities;Signal Pathway;Signal Transduction;synergism;synthetic cannabinoid;Teratogens;Testing;trend;Ultrasonography;United States National Institutes of Health;vasculogenesis;virtual;young adult;Zebrafish

PROJECT_TITLE: Prenatal alcohol/cannabinoid co-exposures and fetal brain development


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Endocrine Disruptors;Genetics;Human Genome;Liver Disease;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: 8. Project Narrative This project investigates the underlying biological mechanisms whereby environmental chemicals alter the expression of genes that control physiological processes that affect human health and liver-based disease. This research is centered on the effects of foreign chemicals on gene transcription events whose dysregulation leads to non-alcoholic fatty liver disease, which affects an estimated 25% of all US adults and is a major cause of advanced disease and liver failure. Overall, the findings obtained are expected to increase our understanding of the effects of environmental chemical exposures on hepatic metabolism and the development of liver disease.

PI_NAMEs: WAXMAN, DAVID J (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Abbreviations;Address;Adult;advanced disease;Affect;Agonist;Architecture;Automobile Driving;Benzene;Biological;blood glucose regulation;carbohydrate metabolism;cell type;Cells;Chemical Exposure;Chemicals;Chromatin;Chromatin Loop;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;constitutive androstane receptor;CRISPR interference;Deoxyribonucleases;Dependovirus;Development;Diagnosis;Diet;Disease;Disease Progression;endonuclease;Environment;environmental chemical;environmental chemical exposure;Environmental Pollutants;Enzymes;Epigenetic Process;Etiology;Evaluation;Event;Exposure to;Fatty Liver;fatty liver disease;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;gene repression;Gene Targeting;Genes;Genetic Transcription;Genome;Genomics;Guide RNA;Health;Hepatic;Hepatic lobule;Hepatocyte;High Fat Diet;Human;in vivo;Industrialization;Inflammation;insight;interest;Knock-out;Ligands;Link;lipid biosynthesis;lipid metabolism;Liver;Liver Cirrhosis;liver development;Liver diseases;Liver Failure;liver metabolism;Lobule;Mediator;Metabolic Pathway;Metabolism;Mitochondria;Modeling;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel marker;Nuclear;Nuclear Pore Complex;Nuclear Receptors;Orthologous Gene;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Physiological Processes;Positioning Attribute;PPAR alpha;pregnane X receptor;prevent;Primary carcinoma of the liver cells;Process;programs;promoter;Proteins;prototype;receptor;Receptor Activation;Research;Role;Serotyping;single nucleus RNA-sequencing;Site;Specificity;Testing;therapeutic target;Time;Tissues;transcription factor;transcription termination;transcriptome;transcriptomic profiling;Untranslated RNA;Work;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Xenobiotic-responsive hepatic long non-coding RNAs

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cadmium (Cd) is a potential neurotoxicant positively associated with cognitive impairments and neurodegenerative diseases in humans. Since the gut microbiome is a target of Cd toxicity and the gut-brain axis is important for regulating neurological functions, this project aims to determine the role of the gut-brain axis in regulating Cd neurotoxicity. This project will determine for the first time the importance of the gut-brain axis in Cd-induced neurotoxicity, enhance the understanding concerning the neurotoxicity of Cd and other environmental toxicants, and provide translational implications for the design of prevention and intervention strategies to mitigate Cd neurotoxicity by reprogramming the gut microbiome.

PI_NAMEs: WANG, HAO  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Affect;Alzheimer's Disease;Animals;Antibiotics;autism spectrum disorder;Bacteria;Bacteroides;Bacteroides thetaiotaomicron;Bile Acids;Bioinformatics;Cadmium;Central Nervous System;Cognitive deficits;Communication;cytokine;Data;data integration;design;Development;Disease;disease registry;Dose;dysbiosis;fecal transplantation;Female;Food;General Population;Generations;gut dysbiosis;gut microbiome;gut-brain axis;Heavy Metals;Hippocampus;Human;Impaired cognition;Impairment;Inflammation;Inflammatory;insight;Intervention;Intestinal Content;Intestinal permeability;Knowledge;Lead;Learning;male;Memory;Memory impairment;Mentors;Microbe;microbial;microbiome;microbiome composition;Mus;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurologic;neuroprotection;neurotoxic;neurotoxicity;Neurotoxins;novel;Outcome;Parkinson Disease;Pathway interactions;Phase;Play;Poison;Preparation;Prevention strategy;Public Health;remediation;remote sensing;Research;response;Role;Smoking;Source;Statistical Models;Testing;Time;Toxic effect;Toxic Environmental Substances;Training;Volatile Fatty Acids

PROJECT_TITLE: Understanding the role of the gut-brain axis in modulating Cadmium neurotoxicity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative Pancreatitis is a painful condition in which pancreatic enzymes are not properly routed to the small intestine and instead damage pancreatic cells. I will study pancreatic triacylglycerol lipase (PTL) to determine if it self-regulates by filamentation to prevent lipase activity during vesicular storage, in a similar fashion to lipoprotein lipase (LPL). These studies will uncover how LPL and PTL are stored inside of vesicles, revealing an innovative path to stabilize inactive PTL structures and prevent PTL from damaging pancreatic cells during pancreatitis.

PI_NAMEs: GUNN, KATHRYN HARRIS (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Address;Adipocytes;Adopted;Affect;Amylases;Antibodies;Binding;Blood;Blood capillaries;Cell Death;Cell Line;Cells;Centrifugation;Chylomicrons;Cryo-electron tomography;Cryoelectron Microscopy;Cues;Cytoplasmic Granules;Data;Development;Diagnostic;Disease;enzyme activity;Enzyme Precursors;Enzymes;Equilibrium;Feedback;Filament;Foundations;Freezing;Gastrointestinal tract structure;Health;Heparan Sulfate Proteoglycan;Heparin Binding;Human body;Immunofluorescence Microscopy;In Situ;In Vitro;in vivo;Inflammation;Informal Social Control;innovation;knock-down;Learning;Life;Lipase;Lipids;Lipoprotein (a);lipoprotein lipase;Mass Spectrum Analysis;Metabolic;Metabolic syndrome;Metabolism;Microscopy;Molecular Conformation;Monitor;monomer;nanobodies;Negative Staining;novel;novel therapeutics;Nutritional;Pain;Pancreas;pancreatic cell line;Pancreatic enzyme;Pancreatitis;Phase;Phenotype;Phospholipase;Phospholipids;Play;prevent;Proteins;Regulation;Research;Research Personnel;Role;Route;Secretory Vesicles;Signal Transduction;skills;Small Intestines;Solid;spatiotemporal;Structure;success;Techniques;Tomogram;trafficking;Training;Triglycerides;Very low density lipoprotein;Vesicle;Visualization;Western Blotting;Work;Yeasts

PROJECT_TITLE: Self-regulation of Lipases by Changes to Quaternary Structure


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Molecular detection of pathogens is at the core of modern surveillance and outbreak investigation and response and molecular techniques have been established for use by the FDA’s Veterinary Laboratory Investigation and Response Network (FDA VetLIRN). This equipment-only grant is to support the purchase of the QuantStudio 3 real-time PCR system for a VetLIRN member laboratory (Ryan Veterinary Hospital Clinical Microbiology Laboratory at the University of Pennsylvania). Purchase of this equipment will maintain and expand our capacity to perform testing for organisms highly relevant to VetLIRN’s overall mission.

PI_NAMEs: COLE, STEPHEN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: MILLER, MEGAN

PROJECT_TITLE: Purchase of a Real-Time Polymerase Chain Reaction System to Maintain and Expand VetLIRN Capacity

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (01)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Physical Activity;Prevention;Substance Misuse

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative Repeated binge drinking is associated with elevated systolic blood pressure, which confronts more than half of mid-life adults in the United States. This K99/R00 application proposes training and research to develop a research strategy that integrates vascular physiology, physical therapies, and alcohol-related health. This will address the gaps in knowledge of mechanisms underlying alcohol-attributable contribution to elevated blood pressure and help identify/develop therapeutic approaches to decrease the burden of hypertension in mid-life adults.

PI_NAMEs: HWANG, CHUEH-LUNG  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Address;Adult;Aerobic Exercise;Age;age group;age related changes;Aging;alcohol abstinence;alcohol research;Alcohols;Area;Arteries;Attention;binge drinker;binge drinking;Biopsy;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;career;career development;Clinical;Data;Development;Development Plans;early onset;effective intervention;Effectiveness;Environment;Event;exercise intervention;exercise training;Fatty acid glycerol esters;fitness;Foundations;Goals;Health;Hour;Human;Hypertension;improved;Interval training;Intervention;Knowledge;longitudinal design;Measures;Microvascular Dysfunction;middle age;Mission;National Institute on Alcohol Abuse and Alcoholism;Nerve;Norepinephrine;normal aging;Phase;Physical therapy;Physiology;Population;prevent;Prevention Research;Public Health;randomized controlled design;receptor;Recording of previous events;Reporting;Research;Research Personnel;Research Training;Resistance;response;Rest;Role;Site;skills;Therapeutic;therapeutic target;Training;United States;United States National Institutes of Health;urinary;Urine;vascular injury;vasoconstriction;Vasoconstrictor Agents;Vasodilation;young adult

PROJECT_TITLE: Reducing blood pressure in mid-life adult binge drinkers: the role of microvascular function and sympathetic activity


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health;Suicide

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Adolescent suicide is a public health issue of critical priority, with rates rapidly increasing, and suicidal ideation (SI) is one of the most robust predictors of death by suicide. Adolescents that belong to a sexual- or gender- minority (SGM) group are at a significantly greater risk of experiencing SI; thus, identifying underlying processes that contribute to the development of SI in SGM youth are crucial in order to pinpoint intervention targets to aid in preventing death by suicide. As part of a larger longitudinal study, the current proposal will evaluate a potential mechanism linking SGM identity to increased SI risk via interactions with low social reward responsiveness and interpersonal stress – the proposed project will be the first to test this pathway by leveraging an innovative approach with a large high-risk sample of adolescents and will identify novel targets for intervention.

PI_NAMEs: CARLTON-SMITH, CORINNE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 17 year old;Acute;Adolescence;Adolescent;adolescent suicide;aged;Anhedonia;Behavior;Behavioral;career;Cause of Death;cisgender;Clinical;Communities;Data;Data Analyses;Data Collection;depressive symptoms;design;Development;Discrimination;efficacious treatment;Electroencephalography;experience;Exposure to;Feedback;Feeling suicidal;Fellowship;follow-up;Funding;Gender;gender minority youth;Grant;Heterosexuals;high risk;Hospitals;Influentials;innovation;Inpatients;Intervention;Interview;Link;Longitudinal Studies;Measures;Mediating;member;Mental Depression;Mentorship;Methods;Minority;neural;novel;Participant;Pathway interactions;Patient Self-Report;Pattern;peer;peer victimization;Prejudice;Prevalence;prevent;Process;Psychiatric therapeutic procedure;Psychopathology;Public Health;public health priorities;Recording of previous events;Reporting;Research;Rewards;Risk;Role;Sampling;Scientist;Severities;sexual minority;skills;social;Social Environment;social stigma;Social support;Stress;stressor;Structure;suicidal adolescent;suicidal behavior;suicidal morbidity;Suicide;suicide rate;Surveys;System;Telephone;Testing;Thinking;Time;Training;Work;Writing;Youth

PROJECT_TITLE: Social Reward Responsiveness and Interpersonal Stress as Predictors of Suicidal Ideation in Sexual-and Gender-Minority Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Cancer

PHR: Project Narrative: We will study the dynamics of the signaling cascade that activates the mitotic checkpoint and develop a mathematic model to understand and predict the behavior of the mechanisms underlying the signaling cascade. We will use this understanding to investigate how aberrant checkpoint signaling increases the frequency of chromosome missegregation in cancerous cells.

PI_NAMEs: JOGLEKAR, AJIT  (contact)

PROJECT_TERMS: Anaphase;behavior prediction;Behavioral Mechanisms;biological systems;cancer cell;Cancerous;Cell Cycle Regulation;Cell division;Cells;Cellular biology;chromosome missegregation;Chromosome Segregation;data modeling;Ensure;Experimental Models;Frequencies;Genomic Instability;Goals;Kinetochores;mathematical model;Mitotic Checkpoint;Nature;Process;recruit;Signal Transduction;Signaling Protein;Systems Biology;Theoretical model

PROJECT_TITLE: The systems biology of mitotic checkpoint signaling and its relevance to cancer cell biology


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative: The goal of this study is to test the safety and efficacy of mesenchymal stromal cell-therapy for reducing pain and pancreas fibrosis and dysfunction associated with chronic pancreatitis and to understand any mechanisms of protection. If proven effective, such a strategy can be used as a therapeutic option for chronic pain associated with chronic pancreatitis and other diseases.

PI_NAMEs: WANG, HONGJUN  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Accreditation;Acinar Cell;Acute Pain;addiction;adult stem cell;Adverse event;Aftercare;Allogenic;animal data;Animal Model;Animals;Anti-Inflammatory Agents;Anxiety;Apoptotic;Autoimmune Diseases;Biochemical Pathway;Bone Marrow;cell bank;Cell Death;cell motility;Cell Physiology;cell preparation;Cell Therapy;cell type;central sensitization;Cessation of life;Choristoma;Chronic;chronic pain;chronic pancreatitis;Clinical Trials;Clinical Trials Data Monitoring Committees;critical limb Ischemia;Cyclic GMP;cytokine;Data;Diabetic Neuropathies;Disease;Disease Marker;Disease remission;Double-Blind Method;experience;Fibrosis;Functional disorder;Goals;Harvest;Human;Hypersensitivity;Immunophenotyping;immunoregulation;improved;improved outcome;Inflammation;Inflammatory;Informed Consent;Infusion procedures;Injections;Injury;insight;Institutional Review Boards;Interdisciplinary Study;Intervention;Intestines;Knee Osteoarthritis;Manuals;Measures;Mental Depression;Mesenchymal Stem Cells;mesenchymal stromal cell;metabolomics;Mitotic;monocyte;Morphology;mouse model;Multiple Trauma;Mus;Narcotics;Neurologic;Neuropathy;novel;novel strategies;operation;Opiate Addiction;Opioid;Overdose;Oxidative Stress;Pain;pain reduction;pain relief;Pancreas;Pathway interactions;Patient Outcomes Assessments;Patients;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phase;Prefrontal Cortex;Preparation;protective effect;Protocols documentation;Quality of life;randomized placebo-controlled clinical trial;response biomarker;Risk;Rodent Model;Safety;safety testing;Serum;single-cell RNA sequencing;Spinal Cord;Statistical Data Interpretation;Symptoms;Syndrome;Testing;Therapeutic;Tissues;treatment strategy;Visceral

PROJECT_TITLE: Safety and Efficacy of Mesenchymal Stem Cells in the Treatment of Chronic Pancreatitis and Its Associated Pain


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Neurodegenerative diseases including Alzheimer’s disease and related tauopathies impact millions of individuals and with cases on the rise, there is a desperate need for effective therapeutic options. Impairments in protein quality control mechanisms contribute to pathology by allowing the accumulation of toxic protein species. In this proposal, I will investigate the ability of a novel target to promote protein quality control machineries in neurons, offering a strategy to prevent or delay the onset of neurodegenerative pathology and identifying a potential target for therapeutic intervention.

PI_NAMEs: OWENS, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: activating transcription factor;aging population;Alzheimer's Disease;Autophagocytosis;Behavior;Behavioral;behavioral outcome;behavioral phenotyping;Binding;Binding Sites;Biochemical;Biogenesis;Biology;Brain;career;Cell Culture Techniques;Cell Death;Cell model;Cell Physiology;Cell Survival;cell type;Cells;ChIP-seq;Clear Cell;Cognition;Cognitive deficits;Data;density;Deterioration;differential expression;Disease;DNA;DNA Binding;druggable target;effective therapy;Evaluation;Foundations;Functional disorder;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Health;Healthcare Systems;Histologic;Homeostasis;hyperphosphorylated tau;Impairment;improved;In Vitro;in vivo;Individual;inducible Cre;insight;Investigation;knock-down;Knock-out;Knockout Mice;Lysosomes;Measures;misfolded protein;Modeling;Molecular;molecular phenotype;molecular targeted therapies;morris water maze;mouse genetics;mouse model;Mus;nemo-like kinase;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;Neurons;novel;object recognition;Organelles;overexpression;Pathologic;Pathology;Pathway interactions;Play;Population;prevent;Progressive Disease;protein aggregation;Proteins;Quality Control;Recycling;Regulation;Reporting;Research;Research Personnel;Resources;Role;Short-Term Memory;Signal Pathway;Synapses;targeted treatment;tau Proteins;Tauopathies;Therapeutic;Therapeutic Intervention;therapeutically effective;Training;transcription factor;transcriptome sequencing;transcriptomics;wasting

PROJECT_TITLE: Evaluation of TFAP4 regulation of lysosome biogenesis and modulation of tau pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Humans and other animals use olfaction, the sense of smell, to perform a number of essential behaviors, including detecting food and avoiding predators. This work aims to understand how the piriform cortex, a brain region important for processing odor information, represents relationships between odors, and how these relationships may change depending on an animal's experience and learning. Results from this study will contribute to a broader understanding of how learning shapes sensory perception, and offers potential benefits for understanding and treating olfactory dysfunction observed in numerous neurological disorders.

PI_NAMEs: D'ALESSANDRO, ISABEL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Affect;Animals;Behavior;Behavioral;Behavioral Assay;Brain;Brain region;Categories;chemical group;Chemicals;Chronic;Citrus;Complex;contextual factors;Cues;density;Electrophysiology (science);Environment;experience;experimental study;flexibility;Food;Genetic;genetic manipulation;Human;Implanted Electrodes;insight;Learning;Limes;Memory;Modeling;Mus;Nervous System Disorder;neural;neural patterning;Neurons;Odors;olfactory bulb;Olfactory Cortex;Olfactory dysfunction;Olfactory Pathways;Pattern;Perception;Perceptual learning;piriform cortex;Recurrence;response;Rewards;Role;Sensory;sensory neuroscience;sensory system;Shapes;Smell Perception;statistics;Stimulus;Structure;Testing;Time;Training;Translating;virtual reality;virtual reality environment;Visual;Work;Writing

PROJECT_TITLE: Mechanisms of experience-dependent odor categorization in the olfactory cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (46)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Stroke;Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Intracortical brain-computer interfaces (iBCIs) have the immense potential to restore motor function for individuals with motor disabilities, through directly accessing the neural signals driving movement. However, multiple factors necessitate electrodes being surgically implanted in less desirable cortical regions, due to brain damage (e.g., stroke), neurovasculature or surgically inaccessible cortex, thus comprising access to the required neural signals and hindering the clinical translation of BCI technologies to populations that would most benefit from it. To bridge this gap, in this proposal, we will investigate the amount of whole-body movement information that can be extracted in a single region of human motor cortex and quantify the degree to which we can modify the functional architecture of the implant site itself to support the desired iBCI application, laying the groundwork for developing versatile iBCI applications for a variety of clinical populations.

PI_NAMEs: SCHONE, HUNTER  (contact)

PROJECT_TERMS: Ankle;Architecture;Area;arm;arm movement;Automobile Driving;Body part;brain computer interface;BRAIN initiative;Brain Injuries;career;Cervical spinal cord injury;Clinical;clinical translation;Clinical Trials;clinically relevant;Computers;Data;design;Development;Electrodes;Engineering;Environment;Exhibits;expectation;experience;Fellowship;foot;Foundations;Freedom;functional electrical stimulation;Functional Magnetic Resonance Imaging;Goals;grasp;Hand;Head;Human;Imagery;Implant;implantable device;improved;Individual;insight;Investigation;Ipsilateral;Learning;Limb Prosthesis;Limb structure;Link;Maps;Motor;motor control;Motor Cortex;Motor disability;motor impairment;motor learning;Movement;multi-electrode arrays;neural;Neuronal Plasticity;neuroprosthesis;Neurosciences;neurotransmission;Operative Surgical Procedures;Outcome;Participant;Performance;Population;professor;Property;Research;Research Personnel;response;Robotics;Self-Help Devices;Site;skills;Stroke;stroke survivor;System;Technology;Testing;Time;Training;Universities;Work;Wrist

PROJECT_TITLE: Using Neuroprosthetics to Promote Plasticity in Cortical Motor Circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (06)]


ORG_DEPT: OTOLARYNGOLOGY

PHR: NARRATIVE Kaposi sarcoma (KS) is the most common cancer among AIDS patients and is caused by a virus our laboratory discovered called Kaposi sarcoma herpesvirus (KSHV). KSHV must express a protein, LANA, to survive in the cell and it has evolved to avoid host cellular immune responses. This proposal identifies these immune evasion pathways for LANA and eliminates them to develop a therapeutic vaccine that will harness the restored immune system to target KS in AIDS patients who have had immune reconstitution but still have persistent KS after antiretroviral treatment. 2

PI_NAMEs: FERRIS, ROBERT L. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;Aging;AIDS population;AIDS with Kaposi's sarcoma;Animals;Antigen Presentation;Antigens;antiretroviral therapy;C57BL/6 Mouse;cancer cell;Cancer Center Support Grant;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cells;Cellular Immunity;Codon Nucleotides;cytotoxic;Environment;Epitopes;Genes;high risk;HIV/AIDS;Human Herpesvirus 8;Immune;Immune Evasion;immune reconstitution;Immune response;Immune system;Immunize;Immunocompetent;Immunologic Surveillance;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;Kaposi Sarcoma;Laboratories;Lymphocyte;Lymphocyte antigen;Malignant Neoplasms;MC38;Messenger RNA;Mus;nanoparticle;NCI-Designated Cancer Center;Nuclear Localization Signal;Ovalbumin;Pathway interactions;Patients;peptide I;Peptides;Persons;phase I trial;pre-clinical;prevent;Protein Engineering;Proteins;Proteolytic Processing;Rag1 Mouse;Recurrence;Refractory;Reporter;Research;Research Priority;response;Schedule;T-Lymphocyte;Therapeutic;therapeutic vaccine;tumor;tumor microenvironment;United States National Institutes of Health;vaccine candidate;Vaccines;vector;Virus

PROJECT_TITLE: Optimization of anti-LANA CD8+ as an therapeutic immunogen (Immune/Microenvironment)


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Mental Health;Neurosciences;Rehabilitation;Social Determinants of Health;Stroke

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite the acknowledgment that chronic stress can negatively impact the quality of life, learning, and thus, rehabilitation outcomes, little research has explored the role of chronic stress on communicative participation and language rehabilitation in people with aphasia (PWA). The purpose of this study is to elucidate the sources of stress related to communication and explore the adaptive and maladaptive self-management strategies that PWA use to decrease perceptions of stress secondary to their language impairment. The results of this project will lay the foundation for interventions that reduce perceptions of stress and facilitate successful communicative participation while providing insight into adaptive coping strategies that can be promoted as an adjuvant to routine, impairment-based language rehabilitation.

PI_NAMEs: JEWELL, COURTNEY C (contact)

PROJECT_TERMS: acute stress;Address;Adjuvant;Adult;Adverse effects;Affect;Anxiety;Aphasia;Appointment;candidate identification;Chronic;Chronic stress;clinical practice;Cognitive;Collection;Communication;Communication impairment;Communities;coping;Coping Behavior;Coping Skills;Data;Development;Ecological momentary assessment;Educational workshop;emotion dysregulation;Emotional;Emotional Disturbance;experience;Exposure to;Face;Fatigue;Fellowship;Fostering;Foundations;Fright;Future;Health;Human;Impairment;improved;Individual;insight;Intervention;Interview;Language;language impairment;Learning;Life;Linguistics;Link;Lived experience;Measures;Mental Depression;Mental Health;Mentorship;Mission;National Institute on Deafness and Other Communication Disorders;Nervous System Physiology;neurophysiology;novel;Occupations;Outcome;Outcome Measure;Participant;Pathologist;Patient Outcomes Assessments;Patients;perceived stress;Perception;Personal Satisfaction;Persons;physical conditioning;Physical Restraint;Play;post stroke;Protocols documentation;Quality of life;recruit;Rehabilitation Outcome;Rehabilitation therapy;rehearsal;Reporting;Research;Research Ethics;Research Methodology;Research Personnel;resilience;Resources;response;Role;Sampling;Secondary to;Self Management;Severities;social;social relationships;Social support;Socioeconomic Status;Source;Speech;stem;Stress;Stress and Coping;stress reduction;stressor;Stroke;stroke-induced aphasia;Structure;success;symposium;Time;Training;treatment response;Universities;Variant;Well in self;World Health Organization

PROJECT_TITLE: Sources and Self-Management of Chronic Stress in People with Aphasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Rehabilitation

PHR: PROJECT NARRATIVE In everyday listening environments, integrating multiple acoustic features is crucial for auditory object perception and stream segregation, yet there is a gap in our understanding of how various spatial and temporal cues are integrated to influence perception in healthy and impaired auditory systems. This project adapts a pitch-based auditory illusion to the spatial domain to investigate spatio-temporal feature integration, examining the biasing effects of sound source location on the perception of relative timing among sequential sounds in normal hearing and single-sided deaf (SSD) adults. The public health significance of this project lies in establishing a simple, innovative task for assessing auditory spatio-temporal feature integration to serve as a more specific functional marker of real-world localization performance than current clinical tasks, and applying this task to SSD patients with and without a cochlear implant (CI) to determine the nature of auditory spatial cue restoration with CI.

PI_NAMEs: KROGER, CAROLYN KAYE (contact)

PROJECT_TITLE: Interactions Between Spatial and Temporal Cues for Auditory Grouping in Normal Hearing and Single-Sided Deaf Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (15)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Major depressive disorder (MDD) remains a prevalent, debilitating, and recurrent disorder that is characterized by cognitive and behavioral inflexibility, the failure to adapt thinking and behavior to meet environmental demands. Given that individuals with a history of MDD often continue to experience ineffective emotion regulation during remission, the proposed study aims to develop a novel theory-based measure of emotion regulation flexibility in everyday life, and to examine its neural underpinnings. By advancing our understanding of real-world emotion regulation flexibility and its precise neural mechanisms, the proposed study will elucidate novel, ecologically-valid treatment targets for depression, that could be modulated using neurobehavioral interventions to improve flexibility and lessen the disease burden of recurrent MDD.

PI_NAMEs: XU, ELLIE PIN (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Adaptive Behaviors;Behavior;Behavioral;Behavioral Mechanisms;biobehavior;Brain;brain control;burden of illness;California;career;Cognitive;cognitive control;Complex;Data;Data Analyses;Data Collection;data integration;Dimensions;disability;Disease;Disease remission;Down-Regulation;Ecological momentary assessment;emotion regulation;Emotional;Emotions;Event;Exhibits;experience;Failure;flexibility;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;improved;Individual;insight;Institution;Intervention;Knowledge;Laboratories;Life;Major Depressive Disorder;Measurement;Measures;Mental Depression;Mental disorders;Mentorship;Methods;Mission;Mood Disorders;multimodal data;National Institute of Mental Health;neural;neural correlate;neural network;neurobehavioral;Neurocognitive;neuromechanism;neuroregulation;novel;Outcome;Pattern;Persons;Positioning Attribute;prevent;Public Health;Recording of previous events;recruit;Recurrence;recurrent depression;Relapse;Reporting;Research;Research Design;Research Training;response;Rest;Risk;Risk Factors;Risk Reduction;Role;rumination;Sampling;Stress;Stressful Event;success;Testing;theories;therapy development;Thinking;Time;Training;trait;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Neural Mechanisms of Emotion Regulation Flexibility and Success in Everyday Life in Depression


ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The proposed research is aimed at elucidating how the multiple trafficking pathways inside cells are coordinated. Unobstructed flow of proteins and membrane through these pathways is required for proper functioning of all cells during normal growth and under stress, and even minor defects can result in severe acquired and inherited diseases. Conserved small GTPases that function as molecular switches are key regulators of these pathways and we will explore mechanisms by which these GTPases integrate cellular pathways into a dynamic network.

PI_NAMEs: SEGEV, NAVA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Autophagocytosis;Biochemistry;Biological Models;Cells;Cellular biology;Defect;Disease;Endocytosis;Exocytosis;Formulation;Growth;Guanosine Triphosphate Phosphohydrolases;Hereditary Disease;Human body;Individual;Malignant Neoplasms;Mediating;member;Membrane;Membrane Microdomains;Minor;Molecular;Molecular Genetics;Monomeric GTP-Binding Proteins;Motility;Nerve Degeneration;Neurodevelopmental Disorder;Nucleotides;Pathway interactions;Proteins;Proteome;rab GTP-Binding Proteins;recruit;Research;Stress;System;trafficking;Variant;Vesicle;vesicle transport;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Coordination of intracellular trafficking pathways by Ypt/Rab GTPases and their GEFs.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Dental, Oral, and Craniofacial Disease;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Early life (childhood) interventions have been proposed to alter food preferences into adulthood; however, longitudinal research has been limited. The goal of this grant is to develop an animal model that explores how early exposure via amniotic fluid and milk or modeling early repeated exposure interventions alter bitter acceptance into adulthood and if these early exposures alter salivary proteins in a lasting way.

PI_NAMEs: ASCENCIO GUTIERREZ, VERENICE  (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Adult Children;Affect;Altered Taste;Amniotic Fluid;Animal Feed;Animal Model;Animals;Award;Behavioral;Birth;Cardiovascular Diseases;Child;Childhood;comorbidity;comparison control;Complex;Consumption;Data;Detection;Development;Diet;dietary control;Disease;Early Intervention;Evaluation;experience;experimental study;Exposure to;Fatty acid glycerol esters;feeding;Female;Food;food consumption;food environment;Food Preferences;Food Safety;Generations;Genetic Predisposition to Disease;Goals;Grant;Health Benefit;Health Food;hedonic;High Fat Diet;Hormones;Human;infancy;Ingestion;Insulin;Intake;interest;Intervention;intrauterine environment;Ions;Lactation;lactation period;Leptin;Life;life span;Linear Models;Literature;Longevity;Measures;Mediating;Methods;Milk;Modeling;Molecular;mother nutrition;Mothers;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obesity;offspring;Pattern;preference;Pregnancy;protein expression;Proteins;Proteomics;Quinine;Rattus;receptor;Research;Research Support;response;Rodent;Rodent Model;Role;Saliva;Salivary Proteins;Series;Signal Transduction;skills;Spottings;Stimulus;Submandibular gland;sugar;Taste Perception;taste stimuli;Techniques;Testing;Time;Toxic effect;Two-Dimensional Gel Electrophoresis;Vegetables;Vertical Transmission;Western Blotting;Work

PROJECT_TITLE: Influence of early exposure to bitter foods on bitter taste sensitivity in adulthood

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Smoking tobacco shortens the lifespan of adults with serious mental illness by 25 years and contributes to $317 billion in healthcare expenditures and indirect loss of earnings and disability benefits. In prior work, we developed a new model to deliver wider-reaching smoking cessation interventions to individuals with serious mental illness. This project proposes to test the efficacy of this new model in a multi-site randomized controlled trial.

PI_NAMEs: VILARDAGA, ROGER  (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Abstinence;Address;Adult;American;Android;arm;Behavior Therapy;Behavioral;Behavioral Sciences;Biochemical;Cardiovascular Diseases;Cause of Death;Cellular Phone;Chronic Disease;cigarette smoke;clinical practice;Clinical Practice Guideline;comorbidity;comparative efficacy;Comprehension;Cost Analysis;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;craving;DA10;Data;Depressive disorder;design;Development;disability;Education;efficacy evaluation;efficacy testing;Elements;Ensure;evidence base;experience;feasibility research;follow-up;Future;General Population;handheld mobile device;health economics;Health Expenditures;Health Policy;high risk population;improved;Individual;innovative technologies;Intervention;Learning;Life Expectancy;life span;Measurement;Measures;Mediating;Mediation;Mediator;Mental Health;Metabolic Diseases;Methodology;Methods;mHealth;mobile application;mobile computing;Modeling;National Institute of Drug Abuse;Nicotine Dependence;nicotine replacement;nicotine use;novel;Outcome;Participant;Patients;Pennsylvania;Persons;pharmacologic;pilot trial;Population;population health;Prevalence;primary outcome;prolonged abstinence;Public Health;Quality-Adjusted Life Years;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Recurrence;Relapse;Research;Respiration Disorders;retention rate;Sampling;Schizophrenia;schizophrenia spectrum disorder;secondary outcome;severe mental illness;Site;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Structure;substance use treatment;Symptoms;Technology;Testing;theories;therapy adherence;Time;Tobacco;Tobacco use;Training;treatment and outcome;Treatment Efficacy;Treatment outcome;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;usability;Work

PROJECT_TITLE: Randomized Controlled Trial of a Novel Smoking Cessation Application Tailored to Individuals with Serious Mental Illness.

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

PHR: The vision of the National Institute on Aging (NIA) IMbedded Pragmatic Alzheimer's disease (AD) and AD- Related Dementias (AD/ADRD) Clinical Trials (IMPACT) is to transform the delivery, quality, and outcomes of care provided to Americans living with dementia and their care partners by accelerating the testing and adoption of evidence-based interventions within HCS. The proposed work will build on IMPACT’s accomplishments to date and support continued work to achieve the full potential of this remarkable national infrastructure and ultimately translate its resources to meaningful improve in the quality of dementia care.

PI_NAMEs: MITCHELL, SUSAN L;MOR, VINCENT  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acceleration;Adopted;Adoption;Alzheimer's Disease;Alzheimer's disease related dementia;American;Award;care outcomes;Caring;Clinical;Clinical Trials;Collaborations;collaboratory;comparative effectiveness study;COVID-19;Data;Dementia;dementia care;effective intervention;Equity;Evidence based intervention;Foundations;Funding Mechanisms;Healthcare Systems;improved;Infrastructure;innovation;Institutional Review Boards;Intervention;Investments;K-Series Research Career Programs;Knowledge;knowledge repository;Long-Term Care;Mission;Monitor;National Institute on Aging;Nursing Homes;Performance;Persons;Process;Quality of Care;Research Personnel;Resources;Services;systems research;Testing;Time;Translating;Vision;Vulnerable Populations;web site;Work

PROJECT_TITLE: NIA AD/ADRD Health Care Systems Research Collaboratory


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PI_NAMEs: PARK, BEN HO (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Anus Neoplasms;Automobile Driving;B-Lymphocytes;biobank;Biological;Biological Markers;Biology;biomarker identification;cancer biomarkers;cancer diagnosis;cancer health disparity;Cancer Patient;cancer recurrence;cancer therapy;CD4 Positive T Lymphocytes;Cell Count;Cells;chemoradiation;Chemotherapy and/or radiation;Clinical;clinical biomarkers;Clinical Data;Code;cohort;Data;Development;differential expression;Disease Outcome;efficacious treatment;Electronic Health Record;Event;Future;Goals;HIV;Human Papillomavirus;Immune;Immune system;Immunity;immunodeficiency;Immunologic Markers;Immunologics;improved;Incidence;Individual;Infection;innovation;lifetime risk;Link;Macrophage;Malignant neoplasm of anus;Malignant Neoplasms;Managed Care;Measures;men;men who have sex with men;Messenger RNA;Modification;Molecular;molecular marker;Monitor;Morbidity - disease rate;multidisciplinary;Natural Killer Cells;new therapeutic target;novel marker;Outcome;outcome prediction;Pathogenesis;Patients;Persons;predictive marker;Prognostic Marker;programmed cell death protein 1;randomized, clinical trials;rare cancer;Recurrence;Recurrent disease;Research;Risk;Role;Sampling;side effect;standard care;standard of care;stem cells;survival outcome;T-Cell Activation;T-Lymphocyte;targeted treatment;therapeutic target;Time;Tissues;Transcript;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment Failure;Treatment outcome;treatment response;treatment strategy;tumor;tumor microenvironment;Tumor Tissue;Untranslated RNA

PROJECT_TITLE: Immune Landscape of Anal Cancer and Survival Outcomes in People with HIV (Immuno/Microenvironment)

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Rehabilitation

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Scoliosis and growth plate disorders are among of the most common pediatric musculoskeletal disorders, causing disfigurement, psychosocial distress. The causes of these disorders of the spine and long bones are likely due to a variety of factors, yet little is known about the genetic factors and signaling pathways involved. This proposal will gain novel mechanistic insight into the regulation of spine and growth plate development and homeostasis through subcellular analysis gene expression and characterization of native protein complexes in these important musculoskeletal tissues.

PI_NAMEs: GRAY, RYAN SCOTT (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adhesions;Adolescent;Animal Sources;Atlases;Automobile Driving;Biogenesis;Biological Process;Biomechanics;Bone structure;Bone Tissue;Cartilage;Cell Physiology;Cells;Chest;Child;Childhood;Chondrocytes;Collection;Complement;Coupled;Cyclic AMP;Defect;Dense Connective Tissue;Development;Disease;Distress;Elements;Environment;Epiphysial cartilage;Fibrocartilages;Fractionation;Funding;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic approach;Genetic Models;Genetic Processes;Genetic Screening;Genetic study;Genetic Transcription;Goals;Growth;GTP-Binding Proteins;Heterogeneity;Homeostasis;Human;Human Genetics;Idiopathic scoliosis;innovation;Inositol;INPPL1 gene;insight;intercalation;Intervertebral disc structure;Knockout Mice;Knowledge;Link;long bone;malformation;Maps;Mass Spectrum Analysis;Modeling;Modernization;Molecular;Molecular Genetics;Morphogenesis;mouse model;Movement;Mus;Musculoskeletal;Musculoskeletal Diseases;mutant;Mutant Strains Mice;Mutation;notochord;notochord development;novel;opsismodysplasia;Pathogenesis;Pathway interactions;Pattern;Penetrance;Perinatal;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Physiology;Predisposition;programs;Property;protein complex;Proteomics;psychosocial;Regulation;Research;Resolution;Role;scoliosis;Severities;Signal Pathway;Signal Transduction;skeletal dysplasia;Spinal Cord;Spinal Curvatures;Spinal Diseases;spine bone structure;Structural defect;Testing;Tissues;transcription factor;Transcriptional Activation Domain;transcriptomics;Variant;vertebra body;Vertebral column;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Expanding expertise to define map protein complexes and signaling essential for skeletal structure and growth.

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project narrative While cognitive impairment is a key domain of alcohol use disorder, the neurocircuit mechanisms underlying this remain poorly understood. This project explores how chronic alcohol-induced changes in the claustrum-anterior cingulate cortex pathway contribute to cognitive control impairments. In so doing, this proposal seeks to introduce the claustrum as a key nucleus underlying alcohol-induced cognitive impairments with therapeutic targeting potential.

PI_NAMEs: WULFF, ANDREAS BRYDENFELT (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: addiction;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Anterior;Atrophic;Attention;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;biocytin;Brain region;Calcium;Cell Nucleus;Cells;Chronic;cingulate cortex;Claustral structure;Cognitive;cognitive control;cognitive function;cognitive reappraisal;Collaborations;Communities;confocal imaging;Confocal Microscopy;consumption measures;Darkness;Data;Decision Making;Development;drinking;Educational process of instructing;Electric Capacitance;Electrophysiology (science);Ensure;Exhibits;experience;experimental study;Fiber;Frequencies;Functional impairment;Genetic;genetic approach;Goals;Heavy Drinking;hedonic;Human;Image;Impaired cognition;Impairment;Impulsivity;Induced Neurons;insight;Institution;Investigation;Label;Long-Term Effects;Measures;Mediating;Membrane;Mentorship;Methodology;microscopic imaging;Morphology;multimodality;Mus;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;new therapeutic target;patch clamp;Pathway interactions;Performance;Photometry;postsynaptic;Protocols documentation;Publishing;Quinine;Records;Relapse;Research Personnel;Resistance;Resolution;responsible research conduct;Rewards;Risk;Rodent;Rodent Model;Role;skills;Stress;Substance Use Disorder;Synapses;Technical Expertise;Testing;Therapeutic;therapeutic target;Training;training opportunity;vapor;Viral;Whole-Cell Recordings

PROJECT_TITLE: Impact of Alcohol on Claustrum Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE The present approach for brain injury monitoring employs multiple invasive brain probes with each probe providing a different measurement which must be individually visualized, analyzed and integrated by the physician. We will develop a brain monitoring solution (the “NeuroProbe Solution”) based on a single probe that will combine the function of multiple individual brain probes. The NeuroProbe Solution has many advantages over current solutions including improved safety, better total patient physiology data integration and a lower cost, and is, thus, expected to lead to improved monitoring and personalized care of patients with brain injury.

PI_NAMEs: SPENCER, DENNIS D (contact);ZAVERI, HITTEN P

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Acute Brain Injuries;Biomedical Engineering;Blood;Brain;Brain Injuries;brain parenchyma;brain tissue;Cephalic;Clinical;Complex;cost;Coupled;Data;Data Analyses;Data Display;data exchange;data integration;data streams;Development;Devices;Diameter;digital data;Electrodes;Electroencephalography;Electronics;Heart Rate;Hemorrhage;implantable device;improved;Individual;Infection;innovation;instrumentation;Intracranial Pressure;Marketing;Measurement;Measures;Military Personnel;Modality;Monitor;multimodal data;multimodality;neural implant;Oxygen;Patients;personalized care;Physicians;Physiologic Monitoring;Physiological;Physiology;pressure;Risk;Safety;Scalp structure;sensor;Signal Transduction;software systems;Source;System;Systemic blood pressure;Tablets;technology development;Temperature;Time;Training;transmission process;trauma centers;Traumatic Brain Injury;Universities;Vendor;Visualization

PROJECT_TITLE: Intracranial multimodal physiological monitoring in acute brain injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Nanotechnology

ORG_NAME: QRONO, INC

PHR: PROJECT NARRATIVE A breakdown in antigen presenting cell (APC) tolerance towards intestinal microbiota plays a critical role in the initiation and perpetuation of inflammation in inflammatory bowel disease (IBD). This proposal seeks to test whether QR401, an APC-targeted AMPK agonist designed to restore tolerogenic APCs in the GI tract, can alleviate intestinal inflammation and disease severity in proof-of-concept murine models of IBD. Successful completion of the proposed project will result in the validation and development of a first-in-class, oral, APC- specific nanotherapy, which could provide a much-needed treatment option for IBD patients.

PI_NAMEs: CARGILL, CHRISTINA PAIGE (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acute;Adult;Adverse effects;Affect;Agonist;Animals;Anti-Inflammatory Agents;Antibodies;Antigen Targeting;Antigen-Presenting Cells;Body Weight;Cardiac;Cells;Chronic;Clinical;clinical development;Clinical Trials;Colitis;Collaborations;Colon;Colorectal Cancer;commensal microbes;Coupled;Custom;cytokine;Data;Dendritic Cells;design;Development;Disease;Dose;efficacy evaluation;Enteral;Ethanol;experience;Fibrosis;Flow Cytometry;Functional disorder;Future;Gastrointestinal tract structure;gut inflammation;gut microbiota;Heart Hypertrophy;High Pressure Liquid Chromatography;high risk;Histology;Human;Immune;immune cell infiltrate;Immune response;Immunology;immunoregulation;Immunotherapy;in vivo;Inbred BALB C Mice;indexing;Inflammation;Inflammatory;Inflammatory Bowel Diseases;interest;Interleukin-10;Interleukin-12;Interleukin-6;Intestinal Diseases;intestinal homeostasis;Intestines;Investments;Label;Lactic Acidosis;Lamina Propria;Length;Macrophage;Mediating;Metabolic;Modeling;mouse model;Mus;nanomedicine;nanoparticle;nanotherapy;Nature;novel;Oral;Oral Administration;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Play;pre-clinical;preclinical study;preservation;Privatization;Production;Rectal Administration;Recurrence;Regulatory T-Lymphocyte;Relapse;Rhodamine;Risk;Role;Serious Adverse Event;Serum;Severities;Severity of illness;Small Business Technology Transfer Research;Splenocyte;Stenosis;symptom management;T cell response;T-Lymphocyte;targeted delivery;targeted treatment;Testing;Therapeutic;therapy development;Tissues;TNF gene;Toxic effect;Treatment Protocols;trinitrobenzene sulfonic acid induced colitis;United States;Universities;uptake;Validation;Work

PROJECT_TITLE: Restoring Tolerance in Inflammatory Bowel Disease with an Oral AMPK agonist Nanomedicine that Targets Antigen Presenting Cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (10)]