NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Ovarian cancer is a lethal malignancy that often begins in the fallopian tubes with serous tubal intraepithelial carcinoma (STIC) and recent work has demonstrated that the presence of STICs is associated with a high risk for primary peritoneal cancer, an ovarian cancer related malignancy. Currently there are few biomarkers for STIC or early ovarian cancer, nor are there consensus guidelines for how to best care for patients with STIC, and we therefore propose to characterize cellular and molecular features of healthy fallopian tubes, STIC and invasive cancer. Our goal is to identify markers in STICs that are indicative of high risk for invasion and possible primary peritoneal cancer so these patients can be selected to undergo more aggressive surveillance or treatment.

PI_NAMEs: SHAH, SOHRAB P (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Adjuvant Chemotherapy;Aneuploidy;Architecture;Biological Markers;Biological Process;biomarker identification;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;cancer initiation;cancer invasiveness;Cancer Patient;Carcinoma;Carcinoma in Situ;Carcinomatosis;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Nucleus;cell type;Cells;Characteristics;Chromosomal Instability;chromosome missegregation;Classification;Clinical Management;cohort;Consensus;Data;Development;Disease;DNA;DNA biosynthesis;DNA Repair;early detection biomarkers;Early Diagnosis;Endowment;Epithelium;Event;Excision;exhaustion;Exhibits;experience;Fimbriated End of the Fallopian Tube;Foundations;Future;Genetic Carriers;genetic testing;genome sequencing;genomic biomarker;Genomic Instability;Genomics;Germ Lines;Goals;Granzyme;Guidelines;high risk;Histology;imaging biomarker;Immune;Immune Evasion;Immunofluorescence Immunologic;improved;Inherited;intraepithelial;intraperitoneal;Invaded;Invasive Lesion;Lesion;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;Mediating;micronucleus;Mitotic;Modeling;Molecular;molecular marker;Natural Killer Cells;Neoplastic Cell Transformation;next generation;Operative Surgical Procedures;Ovarian Carcinoma;Ovary;Paraffin Embedding;Pathogenicity;Pathologic;Patient Care;Patient risk;patient stratification;Patients;Pattern;Peritoneal;peritoneal cancer;prevent;Process;programmed cell death ligand 1;programmed cell death protein 1;prophylactic;prospective;Proteins;Recommendation;Recurrence;Regulatory T-Lymphocyte;Risk;Risk Assessment;Risk Reduction;risk stratification;Salpingo-Oophorectomy;Sampling;Serous;Stage at Diagnosis;Stains;Statistical Models;Syndrome;Techniques;Technology;Testing;Therapeutic;Time;Tissues;TP53 gene;Training;treatment guidelines;Tubal Excisions;Tumor-associated macrophages;tumor-immune system interactions;Variant;whole genome;Work

PROJECT_TITLE: Exploiting markers of genomic instability in high-risk pre-invasive ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-L(59)R]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We have discovered a process in the myofibroblasts that may cause the cells to grow quickly after a heart attack. By shutting off this process, we can not only block the cells from growing too quickly but also make them help repair the heart to help it pump stronger.

PI_NAMEs: TANG, YAO LIANG  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Ablation;Adult;angiogenesis;ATAC-seq;Cardiac;cardiac angiogenesis;cardiac regeneration;cardiac repair;Cardiovascular system;cell transformation;Cells;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Clinical;coronary fibrosis;Data;Enhancers;Enzymes;Epigenetic Process;epigenomics;Fibroblasts;Fibrosis;Follicular Lymphoma;GATA4 gene;Gene Deletion;Gene Expression;gene repression;Genetic Transcription;Goals;Heart;Heart failure;heart function;Homologous Gene;improved;In Vitro;inhibitor;innovation;insight;ischemic injury;Knockout Mice;Knowledge;Mediating;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;Myofibroblast;Natural regeneration;novel;novel strategies;Nucleic Acid Regulatory Sequences;paracrine;Pathologic;Pathway interactions;Phenotype;Population;Process;progenitor;programs;Proliferating;Pump;Recombinant adeno-associated virus (rAAV);regenerative;repaired;Repression;response;restraint;Role;single-cell RNA sequencing;stem cell genes;stem cells;Testing;Therapeutic;transcription factor;transcriptome sequencing;transcriptomics;vector

PROJECT_TITLE: Epigenetic reprogramming of cardiac myofibroblasts for cardiac repair

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Nearly half of all hospitalized patients with Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) develop delirium superimposed on dementia (DSD), which is associated with not only significant morbidity and mortality for patients but also considerable suffering for family caregivers. Integration of family members into delirium identification and prevention efforts is feasible and can improve outcomes, but these efforts (including their impact on caregiver outcomes) have not been adequately examined in DSD identification and prevention. The proposed study will examine DSD communication practices/gaps and develop a patient, family caregiver, and clinician-informed communication and engagement care model for collaborative DSD identification and prevention using intervention mapping, a framework to develop theory and evidence-based health interventions.

PI_NAMEs: GOLDEN, BLAIR POLLITT (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;Adult;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Attitude;Award;career;career development;caregiver stress;Caregivers;Caring;Characteristics;Clinical;clinical care;Clinical Trials Design;Communication;Delirium;Dementia;demographics;design;Detection;Development;Development Plans;Discipline;Distress;Education;Ensure;Environment;evidence base;Evidence based program;experience;Faculty;Family;Family Caregiver;Family member;Focus Groups;Goals;Health;Health system;Hospitalists;Hospitalization;Hospitals;Impairment;implementation evaluation;improved;improved outcome;Individual;Infrastructure;Institution;instrument;Intensive Care;Intervention;intervention mapping;Knowledge;Lead;medical schools;member;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Nurses;older adult;Outcome;Patient Care;Patient Recruitments;Patient-Centered Care;Patients;Personal Satisfaction;Physicians;Pragmatic clinical trial;preference;prevent;Prevention;Prevention strategy;Probability;Process;programs;Provider;Public Health;Records;recruit;Reporting;Research;Research Personnel;Research Project Grants;Role;Scientist;Secure;Source;Structure;success;Surveys;symposium;Symptom Burden;Testing;theories;Time;tool;Training;Universities;Variant;Wisconsin;Work

PROJECT_TITLE: Engaging Hospitalized Patients and Family Caregivers to Identify and Prevent Delirium Superimposed on Dementia: An Intervention Mapping Approach.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of human cancers (currently the 3rd leading cause of cancer death in the US), and existing therapies confer unsatisfactory clinical responses. The tumor microenvironment (TME) of PDAC is among the most inhospitable of any cancer type, and the ability of pancreatic tumor cells to survive and grow under these conditions likely contributes to their recalcitrant behavior. The main goals of our proposal are to define the molecular mechanisms by which PDAC cells adapt to these nutrient- and oxygen-deprived (“arid”) environments, determine how such environments affect interactions between tumor cells and other cells making up the TME, and to identify drug vulnerabilities that can be exploited for therapy.

PI_NAMEs: DANG, CHI V. (contact);STANGER, BEN Z

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: aerobic glycolysis;Affect;Amino Acids;Animal Model;Area;Aridity;Back;Behavior;Biomass;Blood Vessels;Branched-Chain Amino Acids;cancer cell;Cancer Etiology;cancer type;Cell Culture Techniques;Cell division;cell growth;Cell Proliferation;Cell Separation;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;chemotherapy;Citric Acid Cycle;Clinical;coping;CRISPR screen;Dependence;deprivation;Diffusion;DNA Damage;Environment;experimental study;Generations;Genes;genome wide screen;Glucose;Goals;Growth;Heterogeneity;Human;Hypoxia;Immune;In Vitro;in vivo;Individual;inhibitor;insight;Inter-tumoral heterogeneity;Label;Lipids;macromolecule;Malignant Neoplasms;Metabolic;metabolic abnormality assessment;metabolic profile;metabolomics;Methods;Modeling;Molecular;Myeloid-derived suppressor cells;neoplastic cell;Nutrient;nutrient deprivation;Oxidative Phosphorylation;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic stellate cell;Pathway interactions;Perfusion;Pharmaceutical Preparations;Phenotype;Production;Proliferating;Protocols documentation;refractory cancer;Resources;response;Serum;Source;standard of care;System;targeted treatment;Testing;Therapeutic;therapy resistant;Translations;tumor;tumor microenvironment;Warburg Effect;whole genome

PROJECT_TITLE: Defining metabolic adaptations within the PDAC "arid" tumor microenvironment

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The epithelial cells that line the intestinal tract each build hundreds of finger-like protrusions referred to as ‘microvilli’, which extend into the gut lumen. Although microvilli are essential for nutrient absorption and other aspects of intestinal physiology, there is little information on mechanisms that control their growth. The proposed studies will elucidate molecular pathways that lead to the assembly of these protrusions during intestinal epithelial cell differentiation and thus may provide insight on the basis of human diseases characterized by loss of microvilli.

PI_NAMEs: TYSKA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Actins;Activities of Daily Living;Apical;apical membrane;Architecture;Area;Binding;Biological Models;Brush Border;Bundling;Cell Differentiation process;Cell Line;Cell membrane;cellular microvillus;Complex;Cultured Cells;Data;Defect;density;Electron Microscopy;Enterocytes;Epidermal Growth Factor Receptor Pathway Substrate 8;Epithelial Cells;Epithelium;Event;Exhibits;Filament;Fingers;Funding;Glycocalyx;Growth;human disease;Image;Imaging technology;In Vitro;in vivo;Individual;insight;Internet;intestinal epithelium;Intestines;Knockout Mice;Label;light microscopy;malformation;Maps;mechanical force;Membrane;Microbe;Microfilaments;Mitotic spindle;Molecular;Morphogenesis;mouse model;novel;Nutrient;nutrient absorption;Nutrient availability;pathogen;Pathology;Pathway interactions;Physiology;polymerization;Polymers;Positioning Attribute;Property;Proteins;Qualifying;reconstitution;recruit;Role;Site;Small Intestines;solute;Specific qualifier value;Structure;superresolution microscopy;Surface;System;Technology;Testing;Time;Tissues;uptake;Villus

PROJECT_TITLE: Role of actin bundlers during enterocyte differentiation

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE This project will assess the protective role that B lymphocytes and their antibody products play in the anti- tumor immune response. Completion of this project is expected to lead to effective novel treatments for cancers.

PI_NAMEs: HAAS, KAREN M (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acetylgalactosamine;adaptive immune response;Adjuvant;Adoptive Cell Transfers;anti-tumor immune response;Antibodies;Antibody Response;Antigens;Antitumor Response;B-Lymphocyte Subsets;B-Lymphocytes;Binding;cancer cell;cancer therapy;Carbohydrates;CD4 Positive T Lymphocytes;Cell Communication;cell killing;Cells;Circulation;Complement;Complement Inactivators;Data;Development;Flow Cytometry;Fostering;Germ Lines;glycosylation;Goals;Human;Immune response;immunogenic;Immunoglobulin M;immunomodulatory strategy;in vivo;interest;Knowledge;Link;Malignant Neoplasms;Monoclonal Antibodies;mouse model;Mucins;Mus;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;Pathway interactions;Patients;Peptides;Phenotype;Play;Polysaccharides;Population;Prognosis;programmed cell death protein 1;receptor;Recombinant Antibody;Regulation;response;Role;Serine;Shapes;Specificity;Spleen;Supporting Cell;T cell response;T-Lymphocyte;targeted cancer therapy;Testing;therapeutic target;Threonine;Tn antigen;Translating;treatment strategy;tumor;tumor growth;Tumor Immunity;Tumor Promotion;tumor specificity;Tumor-Associated Carbohydrate Antigens;Vaccines;Vertebral column;Work

PROJECT_TITLE: Leveraging B cell specificities for tumor glycans to elicit potent anti-tumor immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Depression;Diabetes;Genetics;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: O-GlcNAcylation is dysregulated in many neurological diseases and metabolic disorders and rapidly modulates GABAAR currents in the hippocampus. Understanding whether O-GlcNAc mediated depression of GABAergic transmission changes in the presence of phosphorylation or a drug of abuse will provide insight on potential therapeutic strategies that can target synaptic dysfunction. Because of this, we propose that an acute increase in O-GlcNAcylation will dictate the polarity of phosphorylation and allosteric modulators on GABAAR function, while a decrease in O-GlcNAcylation can restore inhibition in a disease model.

PI_NAMEs: PHILLIPS, SHEKINAH  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Address;Affect;alcohol use disorder;Allopregnanolone;Alzheimer's Disease;Anti-Anxiety Agents;Anxiety;Award;Barbiturates;Behavior;Benzodiazepines;Binding;Biological Assay;Biology;Bipolar Disorder;Brain;Cells;Chloride Channels;Chronic;clinically relevant;Communication;Cyclic AMP-Dependent Protein Kinases;Data;db/db mouse;Depressed mood;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;disease model;Distant;drug of abuse;Electrophysiology (science);Endocytosis;Endocytosis Induction;Environment;Epigenetic Process;epigenetic regulation;epigenome;Epilepsy;Equilibrium;Exhibits;Frequencies;Functional disorder;GABA Modulators;gamma-Aminobutyric Acid;Gene Expression;Genes;Genetic Polymorphism;Genome;granule cell;Hippocampus;Histone Code;hypnotic;Impairment;in vivo;Individual;induced pluripotent stem cell;insight;Lead;Ligands;Link;Location;Long-Term Depression;Major Depressive Disorder;Mass Spectrum Analysis;Mediating;Mental Depression;Metabolic Diseases;Modeling;Modification;mouse model;Mutation;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurons;neuropsychiatric disorder;neurosteroids;novel;patch clamp;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;pharmacologic;Phase;Phosphorylation;positive allosteric modulator;Post-Translational Protein Processing;Postdoctoral Fellow;Postpartum Depression;Proteins;Publishing;Pyramidal Cells;receptor;receptor function;Regulation;Reporting;Research;Research Project Grants;restoration;Role;Schizophrenia;sedative;Serine;Shapes;Site;Slice;Steroids;Synapses;synaptic function;synaptic inhibition;Syndrome;Techniques;Testing;Therapeutic;therapeutic development;Threonine;Training;transcriptome;Transfection;Transferase;transmission process;Western Blotting;Work;X-linked intellectual disability

PROJECT_TITLE: O-GlcNac Modulation of GABAergic Transmission

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Our sense of hearing relies on the survival of a limited number of inner ear sensory cells throughout our entire lifetime. This project will provide clues about the molecular machinery regulating the stability and shape of the inner ear sensory organelles known as stereocilia. The identification of these molecular players might uncover novel therapeutic targets to maintain the integrity of stereocilia in some types of congenital or noise-induced hearing loss.

PI_NAMEs: VELEZ ORTEGA, ALEJANDRA CATALINA (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Actins;Adult;Affect;Architecture;Auditory;beta Actin;Cells;cellular microvillus;Cochlea;congenital deafness;crosslink;Crosslinker;Cytoskeleton;Data;depolymerization;Development;Exhibits;experimental study;F-Actin;Filament;Fluorescence Recovery After Photobleaching;Freeze Substitution;Freezing;gamma Actin;Hair;Hair Cells;Hearing;hearing impairment;Height;Impairment;In Situ;Inner Hair Cells;Ions;Knowledge;Label;Labyrinth;Lead;Length;Link;Maintenance;Measures;Mediating;Microfilaments;Molecular;Morphology;Mus;mutant mouse model;Myosin ATPase;Natural regeneration;new therapeutic target;noise exposure;Noise-Induced Hearing Loss;Organelles;Organism;Pattern;Physiological;polymerization;Polymers;postnatal;Process;Protein Isoforms;Proteins;Rattus;Reporting;Rest;Sampling;Scanning Electron Microscopy;Sensory;Shapes;sound;Stereocilium;Structure;Supporting Cell;Testing;tomography;Transmission Electron Microscopy;vibration

PROJECT_TITLE: ACTIVITY-DRIVEN PLASTICITY OF THE HAIR CELL CYTOSKELETON


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: This project seeks to: 1) define the role of primary sensory cortical neurons in the initiation of movement, 2) determine the anatomical and functional integrity of the SI locomotor pathway, and 3) examine the therapeutic efficacy of modulating this newly characterized pathway for restoring walking after spinal cord injury (SCI). State- of-the-art cellular-specific optical imaging, optogenetics, and electrophysiology in freely behaving mice combined with viral tracing methods and chemogenetic neuromodulation will accomplish this proposal's objectives. Overall, a greater understanding of the anatomical organization and the functional significance of this novel sensory cortical-locomotor pathway will facilitate the development of new strategies to restore movement after SCI.

PI_NAMEs: SATKUNENDRARAJAH, KAJANA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Anatomy;Axon;Brain;Brain Stem;Calcium;Cells;central pattern generator;Cervical;Development;Disease;Electrophysiology (science);experimental study;Genetic;genetic approach;Head;Health;hippocampal pyramidal neuron;Image;Interneurons;Knowledge;Locomotion;locomotor control;Locomotor Recovery;Lumbar spinal cord structure;Maps;Methods;Microscope;Motor;motor control;Motor Cortex;motor impairment;Movement;Mus;Neurologic;Neurons;neuroregulation;novel;optical imaging;optogenetics;Pathway interactions;Pattern;Resolution;Role;sensory cortex;sensory mechanism;Somatosensory Cortex;Speed;Spinal;Spinal Cord;Spinal cord injury;Therapeutic;Treatment Efficacy;Viral;Walking

PROJECT_TITLE: Sensory cortical control of movement in health and disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Regenerative Medicine;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Statement Allogeneic hematopoietic cell transplantation (HCT) is an increasingly prevalent lifesaving treatment option for hematologic cancer patients. After HCT, patients and their family caregivers must work together as a team to adhere to the complex post-HCT medical regimen, which is critical for good patient health outcomes. The proposed work is a refinement and test of a novel, brief Problem-Solving Intervention to improve patient-family caregiver team management of the medical regimen and thus improve patient and family caregiver emotional well-being and health-related quality of life.

PI_NAMEs: POSLUSZNY, DONNA M (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Allogenic;arm;Attention;Cancer Patient;cancer therapy;Caregiver well-being;Case Series;Cells;Clinic;Clinical;Clinical Treatment;Comparison arm;Complex;cost;Data;efficacy evaluation;Emotional;Engraftment;Event;Evidence based intervention;Family Caregiver;Feasibility Studies;Feedback;Focus Groups;follow-up;graft failure;graft vs host disease;Health;health care service utilization;health management;Health Professional;health related quality of life;Healthcare;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Home;Homologous Transplantation;Hospitals;improved;individual patient;infection risk;innovation;Inpatients;Intervention;intervention participants;intervention refinement;Joints;Life;Literature;Malignant Neoplasms;Medical;Methods;Modification;Morbidity - disease rate;mortality;novel;Outcome;Outcome Assessment;Outcome Study;Patients;Perception;Personal Satisfaction;post intervention;preference;primary outcome;Problem Solving;problem solving therapy;Procedures;Process;programs;Provider;Qualitative Methods;Randomized;Randomized, Controlled Trials;Regimen;Research;Risk;Role;secondary outcome;Self Efficacy;Self Management;Series;Site;success;Testing;Therapeutic Intervention;Time;Transplant Recipients;treatment as usual;Treatment Efficacy;usability;user centered design;Videoconferencing;Well in self;Work

PROJECT_TITLE: Dyadic Intervention to Improve Patient-Family Caregiver Team-Based Management of the Medical Regimen after Allogenetic Hematopoietic Cell Transplantation

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: This proposal pursues to understand how membrane proteins are selectively distributed to different compartments in heart muscle cells, so that they can perform specific functions in control and diseased hearts in both sexes. The potential positive impact of these studies is to gain new knowledge of how heart muscle cells normally produce and ship proteins, communicate with each other, how such processes go wrong in heart diseases in both sexes, and how to design new drugs targeting the selective shipment of these proteins to relieve adverse symptoms of heart disease.

PI_NAMEs: CHEN, ZHENHUI  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Adrenergic Agents;Adult;Anabolism;Animal Model;Binding;Biochemical;Cardiac;Cardiac Myocytes;Carrier Proteins;Cell membrane;Cells;Chronic;Communication;Complex;Cytoplasm;Data;Dedications;design;Disease;Distal;Endoplasmic Reticulum;Failure;Functional disorder;Golgi Apparatus;Growth;guided inquiry;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Hypertrophy;Immunologics;Immunology procedure;Intercalated disc;Knowledge;Lead;Location;Membrane;Membrane Proteins;Messenger RNA;Microtubules;Molecular;Morphology;Motor;mRNA Translation;Muscle Cells;new therapeutic target;novel;novel therapeutics;Nuclear;Nuclear Envelope;Nuclear Pore;Organ failure;Pathway interactions;Peptide Signal Sequences;phospholamban;phospholemman;Physiological;Preparation;Process;Protein Biosynthesis;protein distribution;Protein Sortings;protein transport;Proteins;Proteome;Proteomics;Pump;Radial;Regulation;response;Ribosomes;Rough endoplasmic reticulum;rough endoplasmic reticulum cisterna;Ryanodine Receptor Calcium Release Channel;Sarcolemma;Sarcomeres;Sarcoplasmic Reticulum;SERCA2a;sex;Site;Sorting;Subcellular structure;Symptoms;System;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;trafficking;Translating;Translations;Transmembrane Domain;Tubular formation;uptake

PROJECT_TITLE: Critical Sorting Steps and Pathways in the Trafficking of Cardiac Sarcoplasmic Reticulum Proteins

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative This revised K24 mid-career development award application has been designed to provide the protected time needed to advance my patient-oriented research (POR) program and my mentoring of new HIV prevention science investigators. Specific synergistic activities are proposed that will allow me to simultaneously expand my POR to priority domestic and international settings and mentor the next generation of investigators, all with the overarching goal of optimizing HIV prevention among opioid-dependent persons.

PI_NAMEs: COPENHAVER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: access restrictions;Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;AIDS prevention;American;Analgesics;Applications Grants;Behavior Therapy;Behavioral;biobehavior;career;Caring;Characteristics;Clinical;clinical practice;Collaborations;Communicable Diseases;Communities;Complement;compliance behavior;design;Disease Outbreaks;Educational Status;evidence base;Evidence based intervention;experience;Face;Funding;Future;global health;Goals;Grant;Health;Health behavior;Health Personnel;Health Promotion;high risk behavior;high risk population;HIV;HIV Infections;HIV risk;Impaired cognition;implementation barriers;implementation science;improved;Incubators;Individual;Injectable;Injecting drug user;Institution;Interdisciplinary Study;International;Intervention;Intervention Trial;K-Series Research Career Programs;Letters;Malaysia;meetings;Mentors;Mentorship;mHealth;National Institute of Drug Abuse;Needle-Exchange Programs;Neurocognitive Deficit;next generation;Ohio;Opiate Addiction;Opioid;opioid agonist therapy;opioid epidemic;opioid use disorder;overdose death;patient oriented;patient oriented research;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Process;programs;Public Health;Research;research data dissemination;Research Personnel;Risk Behaviors;Risk Reduction;Rural;Science;Scientist;Series;service programs;sex;skills;Structure;Substance abuse problem;symposium;Testing;therapy development;Time;Training;treatment program;trend;Uganda;Ukraine;United States National Institutes of Health;Volatilization;West Virginia;Work

PROJECT_TITLE: Optimizing HIV Prevention Among Opioid-Dependent Persons

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Significance of the proposed research During early embryonic brain morphogenesis, development of a single neuron begins with the establishment of axon and dendrite identities, an architecture that is critical for the directed information flow in the brain. Aberrations affecting dendrite development lead to developmental neuropathologies, including intellectual and motor disabilities, epilepsy, autism spectrum disorders, and neuropsychiatric disorders. Using state of the art approaches, cutting edge genetic manipulations, optogenetic activation of second messenger signaling, and lifetime decay FLIM-FRET in vivo measurements, this proposal examines the molecular mechanisms of apical dendrite development in pyramidal neurons in the developing mouse embryonic brain.

PI_NAMEs: SHELLY, MAYA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Affect;Apical;Architecture;autism spectrum disorder;Axon;Binding;Bipolar Neuron;Brain;Cell membrane;Complex;Cues;Cyclic GMP;Cytoplasm;Cytoskeleton;Data;Dendrites;design;Development;Developmental Therapeutics Program;Electroporation;Embryo;Enzymes;Epilepsy;Event;excitatory neuron;extracellular;Fluorescence Resonance Energy Transfer;genetic approach;genetic manipulation;Growth;hippocampal pyramidal neuron;Hippocampus;Image;in utero;in vivo;Intellectual functioning disability;Kinesin;Lead;Light;Link;Measurement;Measures;Mediating;Methodology;Mitosis;Molecular;Molecular Target;Morphogenesis;Morphology;Motor;Motor disability;Multipolar Neuron;Mus;neocortical;nerve stem cell;Neurites;Neuroepithelial;neuron development;Neurons;neuropathology;neuropsychiatric disorder;neuropsychiatry;optogenetics;Pathology;postmitotic;postnatal;prevent;Prevention;Process;Production;progenitor;receptor;Regulation;Research;Rodent;Role;scaffold;Scaffolding Protein;Second Messenger Systems;Semaphorin-3A;sensor;Signal Transduction;Slice;spatiotemporal;Specific qualifier value;therapeutic development;Work

PROJECT_TITLE: Molecular Mechanisms that Initiate Apical Dendrite Development During Embryonic Neuronal Development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Primary Health Care;Rehabilitation;Social Determinants of Health;Telehealth

PHR: NARRATIVE Intact cognitive skills are necessary for independent living, going to work, and managing finances, and any loss of cognitive skills places a burden on society akin to what is seen with Alzheimer’s Disease and Related Dementias. The TelePORT Study (Telehealth-Enhanced Patient-Oriented Recovery Trajectories after Intensive Care) is the first post-intensive care syndrome longitudinal long-term cognitive impairment intervention study. The societal effect from long-term cognitive impairment after critical illness is great as many of these patients are employable adults or functional retirees.

PI_NAMEs: BOEHM, LEANNE M (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Acute respiratory failure;Address;Adult;Affect;Age;age stratification;Alzheimer's disease related dementia;Attention;Behavior;blind;care delivery;caregiver quality of life;Caregivers;Caring;Clinic;Clinic Visits;Clinical;clinical care;Cognition;Cognitive;cognitive function;cognitive skill;cohort;Cohort Studies;collaborative care;comparison control;Complex;Control Groups;cost;COVID-19 pandemic;Critical Illness;Data;Dementia;dementia burden;design;Development;disability;effective intervention;efficacy evaluation;efficacy study;Employment;Evaluation;evidence base;experience;Family member;Financial Hardship;follow-up;Goals;health care service utilization;Healthcare;Home;hospital readmission;Hospitals;Impaired cognition;Impairment;improved;Independent Living;indexing;Institution;Intensive Care;Intensive Care Units;International;Intervention;Intervention Studies;Knowledge;Link;Long-Term Effects;Measurement;Measures;Mental Depression;Mental Health;Methods;Modeling;Monitor;Morbidity - disease rate;Outcome;Outcome Measure;Oxygen;patient oriented;Patients;peer;Persons;physical conditioning;Population;Prevalence;primary outcome;Process;programs;Provider;Psyche structure;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recovery services;Reporting;Research;Resources;retiree;Risk;rural area;Sampling;Schedule;secondary outcome;Self Management;sepsis induced ARDS;Septic Shock;Services;Severities;Site;social;social integration;Social Network;Societies;socioeconomics;Specialist;standard of care;Structure;Survivors;survivorship;Syndrome;Technology;telehealth;Telemedicine;Testing;Time;Travel;trial comparing;Unemployment;uptake;Visit;Work

PROJECT_TITLE: Telehealth-Enhanced Patient-Oriented Recovery Trajectory After Intensive Care

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Physical Rehabilitation;Rare Diseases;Rehabilitation

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project addresses barriers to the development of effective therapies for debilitating and costly falls in parkinsonism, and directly aligns with the NIH Brain Initiative goal to image and modulate human brain circuitry. This study investigates the role of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) for postural instability in PSP, a parkinsonian disorder featuring early and severe balance deficits and falls. Cerebellar neuromodulation will inform our understanding of neural pathways involved in postural instability, a debilitating parkinsonian symptom that is refractory to current therapies.

PI_NAMEs: DALE, MARIAN LIVINGSTON (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Aftercare;balance testing;Basal Ganglia;Bradykinesia;Brain;brain circuitry;BRAIN initiative;career;Cerebellar Nuclei;Cerebellum;Clinical;clinical effect;Clinical Investigator;Clinical Trials;Cognitive;cost;Crossover Design;Data;Deep Brain Stimulation;Development;Disabling;disease model;Double-blind trial;Early Intervention;effective therapy;equilibration disorder;Equilibrium;falls;Fluid Balance;functional decline;functional improvement;Functional Magnetic Resonance Imaging;Funding;Future;Gait;Goals;Human;Image;Impairment;improved;Injury;interest;Intervention;Intervention Studies;Investigation;K-Series Research Career Programs;Laboratories;Lead;Measures;Mentors;Mentorship;Methodology;Methods;Motor;motor control;Motor Cortex;Motor output;Movement Disorders;Musculoskeletal Equilibrium;neural circuit;Neural Pathways;Neurologist;neuroregulation;novel therapeutics;Outcome;Outcome Measure;Parkinson Disease;Parkinsonian Disorders;Patients;Pharmaceutical Preparations;Physical therapy;Posture;posture instability;pressure;prevent;programs;Progressive Supranuclear Palsy;Protocols documentation;Refractory;rehabilitation strategy;Rehabilitation therapy;Research;Research Methodology;Research Personnel;response;Rest;Risk;Role;Site;skills;symptom treatment;Symptoms;Testing;Thalamic structure;Time;Training;Transcranial magnetic stimulation;Translations;United States National Institutes of Health;wearable sensor technology

PROJECT_TITLE: Cerebellar TMS for postural instability in progressive supranuclear palsy


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The research training program in Biomedical Informatics and Data Science at the University of Washington aims to prepare future leaders who will unleash the potential for electronic biomedical data and information to advance research and improve health. These future leaders will utilize informatics and data science approaches to address the significant challenges in health care and biomedicine and will create innovations that will improve health outcomes at the individual and population level.

PI_NAMEs: GENNARI, JOHN H.;HARTZLER, ANDREA L.;TARCZY-HORNOCH, PETER  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Area;Behavioral Sciences;Bioinformatics;Biological;biomedical informatics;Characteristics;Clinical;Clinical Informatics;Clinical Research;Collaborations;collaborative environment;Communication;Communities;computer science;Data;Data Science;Discipline;Education;Educational Curriculum;Educational process of instructing;Electronics;Faculty;Fostering;Foundations;Funding;Health;improved;Individual;Informatics;Information Sciences;Interdisciplinary Study;Leadership;Medical;Methodology;Methods;Modeling;multidisciplinary;Play;Population;precision medicine;programs;Public Health;Public Health Informatics;recruit;Research;Research Methodology;Research Personnel;Research Training;Role;skills;statistics;Students;success;tool;Training;Training Programs;Translating;Translations;United States National Library of Medicine;Universities;Vision;Washington

PROJECT_TITLE: University of Washington Biomedical Informatics and Data Science Research Training Program


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Urologic Diseases

ORG_CITY: DALLAS

ORG_DEPT: UROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and involves a dynamic interplay among prostate, bladder and urethra. The cellular and molecular mechanisms that regulate prostate enlargement and detrusor dysfunction are largely unknown and appropriate mouse models to study the function of individual cell types in the lower urinary tract are lacking. The foundational human tissue and data resource generated here will lead to new testable hypotheses and the development of more effective medications.

PI_NAMEs: STRAND, DOUGLAS WILLIAM (contact);VEZINA, CHAD M.

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adrenergic Antagonists;age effect;aged;Algorithms;Alleles;alpha-adrenergic receptor;Amino Acids;Antibodies;ATAC-seq;Automobile Driving;bench to bedside;Benign Prostatic Hypertrophy;Binding;biobank;Bladder;Bladder Dysfunction;C-terminal;Cell Nucleus;cell type;Cells;Clinical;Clinical Data;combinatorial;computational pipelines;Computer software;Data;data centers;data resource;Data Set;Databases;Development;Disease;Elderly;Elderly man;Engineering;Ensure;Enterobacteria phage P1 Cre recombinase;Exposure to;FAIR principles;Fibroblasts;Frequencies;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome annotation;genome browser;genomic locus;genomic predictors;Genomics;histological stains;Human;human data;human disease;human tissue;Image;improved;In Situ;Individual;inducible Cre;inhibitor;insight;intein;Joints;Knock-out;Label;Link;Lower urinary tract;male;Medical;men;Methods;Molecular;mouse model;Mouse Strains;Multiomic Data;Mus;Mutation;Myofibroblast;N-terminal;National Institute of Diabetes and Digestive and Kidney Diseases;Obstruction;old mice;open source;Operative Surgical Procedures;Organ;Organ Donor;overexpression;Oxidoreductase;Pathway Analysis;Patients;Pharmaceutical Preparations;Population;Process;promoter;Prostate;prostate enlargement;Prostatic;Prostatic Urethra;Protocols documentation;rational design;Reporting;Research;Research Personnel;Resolution;Resources;Response Elements;selective expression;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle;Specificity;Specimen;Stream;Stromal Cells;synergism;System;Testing;Tetracyclines;Therapeutic;therapeutic target;Tissue Banks;tissue resource;Tissues;tool;trait;Trans-Activators;transcription factor;Transgenic Mice;Urethra;urinary;Urine;Validation;Visualization

PROJECT_TITLE: Bedside to bench resources for lower urinary tract research


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because complications associated with preterm birth are the leading cause of infant mortality in the United States. This project is relevant to the NICHD mission because it will provide the foundation to determine if MMP9 or related pathway inhibitors can serve as druggable targets to promote uterine quiescence and reduce the number preterm births.

PI_NAMEs: BURKIN, HEATHER R (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Ablation;Affect;Amniotic Fluid;Animal Model;Automobile Driving;Birth;Birth Rate;Calcium;Calcium Signaling;Data;drug development;druggable target;enzyme activity;Event;experience;experimental study;Foundations;Future;Gap Junctions;Gelatinase A;Goals;health disparity;Human;human tissue;Impairment;improved;Infant;Infant Mortality;Inflammatory;inhibitor;Intervention;Metalloproteases;Mission;MMP9 gene;Modeling;Molecular;molecular drug target;Molecular Target;Mus;myometrium;National Institute of Child Health and Human Development;novel;novel therapeutics;Outcome;Oxytocin;Pathway interactions;Patients;perinatal health;pharmacologic;Pharmacologic Substance;Plasma;Play;Pregnancy;Pregnancy Outcome;Pregnant Uterus;premature;Premature Birth;Premature Labor;prevent;Process;Production;Proteomics;Public Health;Rattus;Regulation;Research;Research Priority;response;Role;SB 3CT compound;Serum;side effect;Signal Pathway;Signal Transduction;Technology;Testing;Tissues;United States;Uterine Contraction;Uterus;Woman;Yin

PROJECT_TITLE: MMP9 Modulation of Uterine Contraction and Birth Timing

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: NEWTON

ORG_NAME: BARRETT TECHNOLOGY, LLC

ORG_STATE: MA

PHR: Project Narrative  With the rising incidence of stroke and rapidly growing medical costs, more effective and efficient rehabili- tation is crucial to handle the increasing burden on our healthcare system. Robotic assistive devices, such as the Barrett Upper-Extremity Robotic Trainer (Burt®), can provide effective, repeatable treatment while reducing the burden on therapists. To improve patient engagement and provide more effective therapy while lightening the load on the therapist, we aim to develop new Burt® SmartAssist™ functionality, a combination of a new adaptive assistance method for the Burt® robot, an intuitive path specification interface, and advanced data visualization features to help therapists take full advantage of the system’s capabilities.

PI_NAMEs: BLACK-SCHAFFER, RANDIE ;MCDONALD, CRAIG  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Area;assistive robot;Attention;chronic stroke;Clinical Research;commercialization;Communication;Communities;cost;data visualization;Development;effective therapy;efficacy evaluation;Elbow;Evaluation;Exercise;experience;Feedback;Focus Groups;Frequencies;functional improvement;Goals;Healthcare Systems;Hospitals;Human;Impairment;improved;Individual;individualized medicine;Intuition;Joints;Medical Care Costs;Medical Device;Methods;Modeling;Motion;Movement;Outcome;patient engagement;Patient-Focused Outcomes;Patients;Performance;Phase;Pilot Projects;prototype;Quality of life;Questionnaires;Randomized, Controlled Trials;Recovery;Recovery of Function;Rehabilitation therapy;Research Personnel;Resources;Robot;robot assistance;robot therapy;robotic system;Robotics;Running;Safety;Self-Help Devices;Shoulder;Small Business Innovation Research Grant;Specific qualifier value;Speed;stroke incidence;stroke rehabilitation;stroke survivor;System;Technology;Testing;Time;Torque;Training;treatment as usual;Upper Extremity;user-friendly;Visual;Work

PROJECT_TITLE: SmartAssist™: Adaptive robotic assistance to maximize patient engagement with the Barrett Upper-Extremity Robotic Trainer (Burt)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: OVERALL PROGRAM PROJECT NARRATIVE The release of IL-1β and the fiery cell death called “pyroptosis” that accompanies this release underlies much of the pathophysiology of inflammatory disease. This Program Project aims to better understand the cellular and biochemical mechanisms governing both canonical and non-canonical pathways for IL-1β secretion, their integration with different modes of regulated cell death, and their links to the pathogenesis of Inflammatory Bowel Diseases (IBD) and Myelodysplastic Syndrome (MDS).

PI_NAMEs: DUBYAK, GEORGE R (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;Alzheimer's Disease;Amyloid;Apoptosis;Apoptotic;Autophagocytosis;Biochemical;Biochemistry;CASP1 gene;CASP3 gene;CASP8 gene;CASP9 gene;Caspase;Categories;Cell Death;cell killing;Cell Lineage;Cell membrane;Cell Physiology;cell type;Cells;Cellular biology;Chaperone Protein Interaction;Chronic;Compensation;Complex;Crohn's disease;cytokine;Cytolysis;Disease;disease model;Dissociation;DNA;Dysmyelopoietic Syndromes;Effector Cell;Elements;Epithelial Cells;extracellular;Extracellular Space;Familial Mediterranean Fever;Functional disorder;gastrointestinal;Genetic;Goals;Golgi Apparatus;granulocyte;gut inflammation;human disease;Immune;Immune response;Immunologics;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Interleukin-1 beta;intestinal epithelium;Investigation;Link;Literature;Lytic;Macrophage;Mediating;Mediator;Membrane;microbial;Molecular;mouse model;Multiple Sclerosis;Mus;Myeloid Cells;Myocardial Infarction;N-terminal;Necrosis;neutrophil;Nonlytic;novel;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Peptide Signal Sequences;Population;Production;programs;Proteins;Publishing;Reagent;Regulation;Reporting;response;restraint;Secretory Vesicles;Signal Transduction;Source;Sterility;Stimulus;structural biology;structural determinants;T-Lymphocyte;Testing;Tissues;trafficking;Ulcerative Colitis;VDAC1 gene

PROJECT_TITLE: Inflammasome and Gasdermin Signaling Networks for Regulation of Pyroptosis and Cytokine Release


PHR: CORE A: PROJECT NARRATIVE This activity serves to organize interproject communication and management and as the interface between the Program Project and the NIAID. This activity also coordinates the External Advisory Board, the Internal Advisory Board and invited Seminar Speakers.

PROJECT_TERMS: Communication;cytokine;Expenditure;Individual;Inflammasome;Infrastructure;medical schools;meetings;National Institute of Allergy and Infectious Disease;operation;Pathology;Preparation;Program Research Project Grants;programs;Progress Reports;Regulation;Reporting;Research Project Grants;Schedule;Services;Signal Transduction;Travel;Universities

PROJECT_TITLE: Administrative Core


PHR: Lay Summary Throughout human history, infectious diseases and inflammatory such as the flu or cold viruses or stomach bugs, have been drivers of human evolution. These threats are so dangerous that humans have evolved redundant mechanisms to neutralize them. The Gasdermin family of proteins helps drive inflammation in the face of these threats. Despite this, little is known about Gasdermin family redundancy, the mechanisms by which Gasdermin family members are regulated and Gasdermin family members role in normal blood cell development. This grant application aims to study these important problems in the context of inflammatory disease.

PI_NAMEs: ABBOTT, DEREK W (contact)

PROJECT_TERMS: Acute;Applications Grants;Aspartate;Bacteria;Biochemical;Biochemistry;Blood Cells;CASP1 gene;CASP3 gene;Caspase;Cell Death;cell killing;cell type;Cells;Cellular biology;cellular engineering;Cellular Membrane;Clinical;Communicable Diseases;Compensation;Complement;cytokine;Dangerousness;Data;design;Development;Disease;Dysmyelopoietic Syndromes;Electrolytes;Ensure;Event;Evolution;Family;Family member;flu;Goals;hematopoietic differentiation;Homeostasis;Human;Immune response;Immune system;Immunologics;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-1 beta;leukemia;Membrane;Mitochondria;Myeloid Cells;novel;Organism;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Protein Family;Proteins;Publishing;Reagent;Recording of previous events;Regulation;response;Role;Sampling;Shapes;Signal Transduction;Site;Stimulus;Stomach;structural biology;VDAC1 gene;Virus;Work

PROJECT_TITLE: Cellular Engineering to identify gasdermin protein networks regulating inflammatory cell death


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Maintaining energy and fluid homeostasis is critical. Disruptions in energy homeostasis cause malnutrition or obesity, and failure to defend fluid homeostasis causes dehydration or hypertension. A better understanding of the relevant circuits can help lead to treatments for disorders of energy balance, such as obesity and diabetes, and can provide targets for understanding and preventing disorders of fluid balance such as dehydration or hypertension.

PI_NAMEs: DANIELS, DEREK  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Agonist;antagonist;Area;Behavior;Behavior Control;Behavioral;Body Fluids;Brain;Brattleboro Rats;Cardiovascular system;Cell Separation;Cells;Central Diabetes Insipidus;Compensation;Consumption;Data;Dehydration;Diabetes Insipidus;Diabetes Mellitus;diabetic rat;Disease;Diuresis;drinking;Eating;energy balance;Failure;feeding;Feeding behaviors;Fluid Balance;genetic manipulation;Genotype;GLP-I receptor;glucagon-like peptide 1;Health;hindbrain;Homeostasis;Hunger;Hypertension;Intake;Laboratories;Lead;Ligands;Liquid substance;Long-Evans Rats;Maintenance;Malnutrition;Modeling;motivated behavior;Motivation;Mutation;neural;neural circuit;Neural Pathways;neuroregulation;novel strategies;Nucleotides;Obesity;Pathway interactions;pharmacologic;Phenotype;Polydipsia;Polyuria;Population;preoptic nucleus;preproglucagons;prevent;Rattus;receptor binding;Residual state;response;restoration;Rodent Model;Satiation;Series;Signal Transduction;Site;Source;Structure;System;Testing;Thirst;Tracer;Vasopressins;Water;Water consumption

PROJECT_TITLE: Parsing the central control of thirst and hunger using a rat model of diabetes insipidus

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Hematology

PHR: NARRATIVE / Public Health Relevance Despite their granulocytic similarities which distinguish them from other myeloid leukocytes, neutrophils, mast cells and eosinophils play non-redundant roles in innate immunity and immune homeostasis. This project will define how these non-redundant functions involve alternative mechanisms of IL-1β production, GSDM family expression and subcellular trafficking, and regulated cell death. The results of these studies will define novel mechanisms for how GSDMD and GSDME mediate granulocyte-specific immune signaling responses which play critical physiological roles during acute infection/tissue damage but contribute to tissue dysfunction in humans with common autoimmune, allergic, or chronic inflammatory diseases.

PROJECT_TERMS: acute infection;Allergic;Allergic Disease;Apoptosis;Apoptotic;Autoimmune;Autophagocytosis;Autophagosome;Biology;CASP1 gene;Caspase;Cell Death;Cell membrane;cell type;Cells;Cessation of life;chronic inflammatory disease;cytokine;Cytoplasmic Granules;Cytosol;Data;DNA;Effector Cell;eosinophil;Exocytosis;extracellular;Extravasation;Family;Feedback;Functional disorder;granulocyte;Homeostasis;Human;Immune;Immune signaling;Immunologic Stimulation;Inflammasome;Inflammatory;Innate Immune Response;Interleukin-1 beta;Leukocyte Elastase;Leukocytes;Lytic;Macrophage;mast cell;Mediating;Membrane Lipids;Metalloproteases;Molecular Chaperones;Mononuclear;Myelogenous;Natural Immunity;neutrophil;Nonlytic;novel;Nuclear Envelope;Pathway interactions;Permeability;Physiological;Play;Process;Production;Property;Protease Inhibitor;Protein Family;Proteins;public health relevance;Regulation;Reporting;response;Role;Secondary to;Secretory Vesicles;senescence;Serine Protease;Serpins;Shapes;Signal Transduction;Signaling Protein;Source;Stimulus;Testing;Tissues;trafficking

PROJECT_TITLE: Alternative pathways of gasdermin function and IL-1beta secretion in granulocytic leukocytes


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Carbon monoxide (CO) gas has been identified as an essential signaling molecule in the human neuronal system and has been shown to have many therapeutic applications. Molecules that create CO gas upon activation with an external stimulus are commonly dubbed CO releasing molecules, or CORMs, and have shown to be vital tool in studying the effect of CO in biological systems. This research proposes to create a new class of CORMs based on organic molecules that efficiently produce CO gas, are directly polymerizable, and have predictable and well-defined products following the release of CO, attributes not currently accessible with state-of-the-art CORMs.

PI_NAMEs: WORRELL, BRADY  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acute;analog;biological systems;biomaterial compatibility;Carbon Monoxide;Cardiovascular Diseases;Chronic;Collaborations;Colorado;Complex;cytotoxic;Development;Future;Gases;gastrointestinal;Health;Human;Human body;improved;Inflammation;Laboratories;learning materials;Ligation;medical schools;member;metal complex;method development;Neurons;new therapeutic target;organ transplant rejection;Pathway interactions;photolysis;polymerization;Polymers;Production;programs;Research;response;Signaling Molecule;small molecule;Solubility;Stimulus;System;targeted treatment;Technology;Therapeutic;tool;Transition Elements;Universities;Water;Work

PROJECT_TITLE: CO Releasing Organic Polymers for Biomedical Applications


PHR: Relevance Inflammasomes play important roles in immune defense against infections and autoimmune/autoinflammatory disorders such as inflammatory bowel disease, multiple sclerosis, and Alzheimer’s disease. Activation of the inflammasomes lead to maturation and secretion of proinflammatory cytokines and pyroptosis, a highly inflammatory form of cell death that triggers cytolysis accompanied by cytokine release. Intriguingly, pyroptosis- and membrane pore-independent function of GSDMD in secretion of cytokines has been demonstrated in neutrophils, epithelial cells, and T cells. The goal of this proposal is to probe mechanisms for pyroptosis- dependent and novel pyroptosis-independent release of proinflammatory cytokines mediated by GSDMD. The outcome will not only provide novel insights into lytic and non-lytic cytokine release, but may also stimulate the development of therapeutics that target inflammatory disorders.!

PI_NAMEs: XIAO, TSAN SAM (contact)

PROJECT_TERMS: Alzheimer's Disease;Apoptosis;Autoimmune;autoinflammatory diseases;Autophagocytosis;Binding Sites;CASP1 gene;CASP3 gene;CASP8 gene;Caspase;Caspase Inhibitor;Catalytic Domain;Cell Death;Cell membrane;cell type;Cells;Collaborations;Complex;Crystallization;cytokine;Cytolysis;Data;Data Analyses;Disease;enzyme substrate;enzyme substrate complex;Epithelial Cells;Event;Experimental Designs;Goals;Human;IL18 gene;Immune;Immune signaling;Immunity;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory modulation;insight;Interleukin-1 beta;Investigation;Knowledge;Lead;Length;Lipid Binding;Lytic;Macrophage;mast cell;Mediating;Membrane;membrane assembly;Molecular;Molecular Chaperones;Multiple Sclerosis;Mus;neutrophil;Neutrophil Activation;Nonlytic;novel;Outcome;pathogen;Peptide Hydrolases;Peptide Signal Sequences;Play;programs;Proteins;Proteomics;receptor;recruit;Regulation;repaired;Reporting;Role;Serine Protease;Signal Pathway;Signal Transduction;Site;Structure;success;T-Lymphocyte;Testing;therapeutic development;therapeutic target;Tissues;Vesicle

PROJECT_TITLE: Molecular mechanisms of gasdermin recognition by proteases and autophagy proteins in cytokine release


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative We have discovered that triple-negative breast cancer (TNBC) cells overexpress the enzyme RNase H2, enabling them to overcome excessive replication stress and survive. Based on this unique feature, we have further demonstrated that RNase H2 inhibition can effectively kill TNBC cells both in vitro and in vivo. The goal of this study is to build on this knowledge to develop novel and effective RNase H2 inhibition-based monotherapy and combination therapy to cure TNBC.

PI_NAMEs: LIN, SHIAW-YIH  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Affect;anti-PD-1;anti-PD1 therapy;Bioinformatics;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Prevention;Breast Cancer Treatment;Breast Epithelial Cells;cancer subtypes;Catalytic Domain;Cell Death;Cell model;Cell Survival;Cells;Characteristics;Chemicals;chemotherapy;Combination immunotherapy;Combined Modality Therapy;CXCL10 gene;cytokine;DNA biosynthesis;DNA Damage;efficacy evaluation;Enzymes;Excision;Exhibits;follow-up;Genetic;Genome;Genomic Instability;Genomics;Goals;immune checkpoint;immune checkpoint blockade;Immunity;Immunotherapy;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Knowledge;Maximum Tolerated Dose;Mediating;mouse model;Mus;Nature;new therapeutic target;novel;overexpression;Pathway interactions;Patient-derived xenograft models of breast cancer;Patients;programmed cell death ligand 1;programmed cell death protein 1;Proteins;RANTES;Recurrent disease;replication stress;Replication-Associated Process;Resistance;response;Ribonucleases;Ribonucleotides;Role;Signal Transduction;Small Interfering RNA;Stimulator of Interferon Genes;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;Toxic effect;Treatment Efficacy;triple-negative invasive breast carcinoma;tripolyphosphate;tumor;tumor growth;tumor-immune system interactions;Xenograft Model

PROJECT_TITLE: RNase H2 is a novel therapeutic target in triple negative breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

PHR: Public Health Relevance  About 1.3 million people suffer from inflammatory bowel disease (IBD) in the United States. With cause of the  disease still elusive, there is currently no cure or preventive measure for the condition. Interluekin-1β (IL-1β) is  a potent pro-inflammatory soluble protein that is highly upregulated in the inflamed intestinal tissues in patients  with Ulcerative Colitis and Crohn’ Disease. It is currently unclear how IL-1β is released by various cell types in  the intestine. In this application, we propose to delineate the biochemical events-mediated by Gasdermin D, a  novel protein participating in driving IL-1 β production and intestinal inflammation. Completion of this project will  provide novel therapeutic strategies to break the pathogenic cross-talk between immune and structural cells and  terminate the non-resolving inflammation.

PI_NAMEs: PIZARRO, THERESA TORRES (contact)

PROJECT_TERMS: Ablation;Address;anakinra;Attenuated;Automobile Driving;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biopsy;CASP1 gene;CASP8 gene;CDC37 gene;CDC37 homolog protein;Cell Physiology;cell type;Cells;Chronic;Colitis;Colon;Compensation;Complex;Crohn's disease;cytokine;Data;design;dextran sulfate sodium induced colitis;Disease;effective therapy;Electron Microscopy;Epithelial Cells;Etiology;Event;Extracellular Space;extracellular vesicles;Family member;Gene Modified;Genetic Polymorphism;gut inflammation;Helper-Inducer T-Lymphocyte;IL1R1 gene;Immune;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-1;Interleukin-1 beta;intestinal epithelium;Intestinal Secretions;Intestines;Knowledge;Length;Lipid Binding;Literature;Maps;Mediating;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;Mutation;Myeloid Cells;Nonlytic;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Signal Sequences;Persons;Polyubiquitination;Predisposition;Preventive measure;Process;Production;programs;Proteins;Proteomics;public health relevance;rapid growth;receptor;recruit;Regulation;response;Role;Secretory Vesicles;Signal Transduction;Sodium Dextran Sulfate;Source;Stimulus;T-Lymphocyte;targeted treatment;TCR Activation;Testing;therapeutic target;Tissues;ubiquitin-protein ligase;Ubiquitination;Ulcerative Colitis;United States;Vesicle

PROJECT_TITLE: GSDMD-dependent IL-1 signaling in intestinal inflammation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lung;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Alzheimer's disease is a debilitating disorder that exerts a substantial and growing impact on public health in the context of an aging population. A sizeable body of research has demonstrated that sleep problems, particularly daytime sleepiness and obstructive sleep apnea, increase the risk of developing Alzheimer's disease pathology and dementia in later life. This project will identify specific and objective measures of diminished daytime alertness that are associated with increased risk of Alzheimer's disease pathology and cognitive decline, which will be a critical advance, allowing those at greatest risk for Alzheimer's disease to be more readily identified so targeted therapies and prevention strategies can be employed.

PI_NAMEs: PLANTE, DAVID T (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;Address;Adult;Affect;aging population;alertness;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;apolipoprotein E-4;Area;Biological;Blood;Blood specimen;clinical phenotype;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Collection;Data;Data Set;Dementia;design;Disease;Disease Progression;disorder prevention;Drowsiness;Early identification;Epidemic;Excessive Daytime Sleepiness;experience;Future;Genetic;Health;human old age (65+);Hypoxia;Impaired cognition;Impairment;improved;Individual;inter-individual variation;Investigation;late life;Light;Link;Longitudinal cohort;Longitudinal Studies;Measures;Meta-Analysis;middle age;modifiable risk;National Institute on Alcohol Abuse and Alcoholism;Natural History;Nature;Nerve Degeneration;Nervous System Disorder;neurobehavioral;Neurocognitive;neurofilament;Neuropsychology;novel strategies;Obstructive Sleep Apnea;Outcome;Participant;Pathologic;Persons;Phosphorylation;Populations at Risk;Positioning Attribute;Prevention strategy;progression risk;prospective;Public Health;Recording of previous events;Research;Risk;Role;Sampling;Severities;Sleep;sleep abnormalities;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;social;Statistical Models;Structural defect;targeted treatment;tau Proteins;tau-1;Testing;Therapeutic;Time;treatment strategy;vigilance;Wisconsin

PROJECT_TITLE: The Role of Impaired Neurobehavioral Alertness in Cognitive Decline and Alzheimer’s Disease Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Nutrition;Pediatric;Polycystic Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Polycystic kidney disease (PKD) is a genetic kidney disease that results in formation of multiple fluid filled kidney cyst that leads to loss of kidney function. We found that a high animal based protein diet fed PKD mice resulted in rapid cystic kidney disease progression through impairing a cellular component called mitochondria and increased a group of blood cells that protects us from fighting infection, called macrophages. Rapid cyst growth was mitigated when mice were fed a plant-based (wheat-gluten) protein diet. The most abundant amino acid in the casein compared to wheat-gluten diet is lysine. This proposal will determine whether specific content within the animal based protein, lysine, impairs the mitochondrial function, activate macrophages and accelerates kidney cyst growth in PKD mice.

PI_NAMEs: SAIGUSA, TAKAMITSU  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Affect;amino acid metabolism;Amino Acids;Animals;Applications Grants;Aspartate;Attenuated;Autosomal Dominant Polycystic Kidney;Blood typing procedure;Caseins;cell injury;chemokine;clinically significant;Consumption;Cyst;Cystic kidney;Cystic Kidney Diseases;cytokine;Cytoprotection;Data;Development;Diet;Dietary Proteins;dietary restriction;disease model;Disease Progression;Elements;Environmental Risk Factor;Epithelial Cells;Family;fighting;Functional impairment;Gene Mutation;Genetic;Gluconeogenesis;glucose metabolism;Glutamates;Gluten;Growth;Immune response;Impairment;improved;Infection;Infiltration;Injury;Intervention;Kidney;kidney cell;Kidney Diseases;Knock-out;Knockout Mice;Liquid substance;Lysine;Macrophage;Meat;Mediating;Metabolic Pathway;Mitochondria;mitochondrial dysfunction;Mus;mutant;Mutation;non-genetic;Oral;Organelles;Outcome;Oxygen Consumption;Pathway interactions;Patients;Phosphoenolpyruvate;PKD1 gene;PKD2 gene;Plants;Play;Polycystic Kidney Diseases;Post-Translational Protein Processing;pre-clinical;preclinical study;Production;Proteins;recruit;Reducing diet;renal epithelium;Renal function;Renal tubule structure;Rodent;Role;Saline;Severity of illness;Sorting;Soy Proteins;Stimulant;Supplementation;Testing;Tubular formation;Tyrosine;Wheat

PROJECT_TITLE: The Role of Wheat-Gluten in Polycystic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Precision Medicine;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because we aim to improve prognostication for patients with advanced cancer by developing frameworks to integrate clinician intuition with machine learning algorithm- based mortality risk predictions (“human-machine collaborations”), a critical step to better identify patients who may benefit from earlier advance care planning and palliative care. This research proposal will optimize an existing machine learning mortality risk prediction algorithm and methodologically assess strategies to present machine learning estimates to clinicians in order to increase prognostic accuracy, advance care planning, and palliative care among patients with advanced cancer. The project is relevant to the NCI's mission by generating fundamental knowledge to inform clinicians, researchers, and policymakers about effective methods to improve and integrate predictive algorithms into clinical practice, thereby allowing better targeting of evidence-based interventions to improve quality of life for patients with advanced cancer.

PI_NAMEs: PARIKH, RAVI BHARAT (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Advance Care Planning;Advanced Malignant Neoplasm;adverse outcome;algorithm development;Algorithms;analytical tool;Area;cancer care;care delivery;career;Caregivers;Caring;Cessation of life;Clinic;Clinical;clinical care;clinical decision-making;Clinical Oncology;clinical practice;Clinical Trials Design;Collaborations;Data;Decision Making;Dependence;design;Development;Discharge Plannings;Disease;Early identification;Electronic Health Record;electronic structure;end of life care;end of life outcomes;Ensure;evidence base;Evidence based intervention;experience;Exposure to;Funding;Goals;health care service organization;health data;Health system;high risk;Human;human model;improved;Industry;Infrastructure;Institution;Intervention;Intuition;Jail;Judgment;Knowledge;Life Expectancy;Link;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Malignant Neoplasms;Medical Oncologist;Medicine;Mentors;Mentorship;Methodology;Methods;Mission;model development;mortality;mortality risk;Multi-Institutional Clinical Trial;Oncologist;Oncology;Palliative Care;Patient Care;Patient-Focused Outcomes;Patients;Performance;Physicians;Policy Maker;Population;Pragmatic clinical trial;prediction algorithm;Predictive Analytics;predictive modeling;Prognosis;prognostic;prognostic algorithm;prognostic tool;prognostication;programs;prospective;Public Health;Qualifying;Quality of Care;Quality of life;Rain;randomized trial;randomized, clinical trials;Recommendation;Relative Risks;Research;Research Personnel;Research Proposals;Resources;Risk;risk prediction;risk prediction model;routine care;Sampling;Scientist;Sepsis;Services;Survey Methodology;Surveys;Symptom Burden;Symptoms;System;Testing;Time;Training;United States;User-Computer Interface;Work

PROJECT_TITLE: Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE STATEMENT Smoke exposure in early life is a significant public health concern because it may predispose smoke-exposed children to substance use and other behavior problems. This study examines youths’ abilities to control their emotions and behavior as pathways that may lead to unhealthy outcomes for smoke-exposed children. The work conducted here may reduce the public health impact of early smoke exposure by identifying targets for prevention and intervention efforts.

PI_NAMEs: MICALIZZI, LAUREN GIOIA (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: 13 year old;addiction;Address;Adolescence;Adolescent;adolescent substance use;Adverse effects;Age;Alcohols;Area;Attention deficit hyperactivity disorder;Attenuated;Behavior;Behavior Control;Behavioral;Birth;career;Child;Child Health;cognitive control;Conduct Disorder;conduct problem;Cotinine;Data;Development;Diagnostic;Drug Addiction;Drug Screening;Drug usage;early adolescence;early onset substance use;Economic Burden;Electrocardiogram;emotion regulation;Emotional;Emotions;Environmental Exposure;environmental tobacco smoke;environmental tobacco smoke exposure;executive function;experience;Exposure to;externalizing behavior;fetal;fetal smoke exposure;fetal tobacco exposure;Fetus;follow up assessment;Future;Goals;Growth;Health Care Costs;High Prevalence;Household;improved;Infant;Informal Social Control;Infrastructure;Intervention;Interview;Knowledge;Learning;Life;Link;Low income;Maintenance;Measures;Mediating;Mediator;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;Mothers;National Institute of Drug Abuse;neurobehavioral;offspring;Outcome;Parents;Pathway interactions;Patient Self-Report;Physiological;Postpartum Period;Predisposition;Pregnancy;prenatal exposure;Prevention;Problem behavior;prospective;Protocols documentation;Psychophysiology;Public Health;Questionnaires;Random Allocation;recruit;Regulatory Pathway;Reporting;Research;Research Design;Research Methodology;resilience;Risk;Risk Factors;Salivary;Sampling;Scientist;Self Perception;Severities;Smoke;Smoking;smoking during pregnancy;Statistical Methods;substance use;Substance Use Disorder;Symptoms;teacher;Teratogenic effects;Time;Training;treatment arm;Universities;Urine;Visit;willingness;Woman;Work;Youth

PROJECT_TITLE: Prenatal Tobacco Exposure: Self-Regulatory Pathways to Externalizing Behaviors

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Cryptococcus neoformans is an opportunistic human fungal pathogen that is ubiquitous in the environment and is an important cause of disease for patients with HIV/AIDS, other autoimmune diseases, and solid organ transplants. The standard model for the study and treatment of cryptococcal disease assumes that infections are caused by a sin- gle strain or genotype but our preliminary studies demonstrate that mixed-strain Crypto- coccus infections are common among a patient population drawn from the southeastern United States. This research will advance public health by estimating the frequency and genetic structure of mixed Cryptococcus infections, identifying environmental lineages of Cryptococcus that contribute to mixed infections, and characterizing epidemiological correlates and health outcomes associated with mixed infections.

PI_NAMEs: MAGWENE, PAUL MITAARI (contact);PERFECT, JOHN R.

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;anti-fungal agents;Autoimmune Diseases;Basidiomycota;Cessation of life;Characteristics;Chronic;chronic infection;Clinical;clinical decision-making;co-infection;Complex;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Data;demographics;detection platform;Disease;drug sensitivity;Environment;Epidemiology;exposed human population;Exposure to;Frequencies;Genetic;Genetic Structures;Genome;genome sequencing;genomic variation;Genomics;Genotype;Geographic Locations;Geography;global health;Goals;Health;Health system;Heterogeneity;HIV Seropositivity;HIV/AIDS;Human;Immune system;Immunocompetent;Immunocompromised Host;Incidence;Infection;Infectious Agent;Life;Link;Macrophage;mortality;Mycoses;Organ Transplantation;Outcome;pathogenic fungus;Pathogenicity;patient population;Patient-Focused Outcomes;Patients;Persons;Phenotype;Phylogenetic Analysis;Population;Prevalence;Public Health;Research;Sampling;Solid;Southeastern United States;Standard Model;Structure;Study models;Time;Travel;Universities;University Hospitals;Virulence;Yeasts

PROJECT_TITLE: Population Structure and Clinical Impact of Multi-strain and Mixed-species Cryptococcal Infections

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: CAMBRIDGE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Mapping the key molecular building blocks (RNA and protein) of cancer cells in their spatial context in tissue is crucial to depict the significant components that drive biological function and pathology. We propose to develop a scalable imaging platform for highly multiplexed, rapid, visualization of protein and RNA in large volume tissue samples at both cellular and molecular level.

PI_NAMEs: YIN, PENG  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Address;Adopted;anti-cancer research;Antibodies;Atlas of Cancer Mortality in the United States;Atlases;bioimaging;Biological Process;Biology;brain tissue;cancer cell;Cancerous;CCRL2 gene;Cell Line;Cell model;cell type;Cells;cellular imaging;Clinical;clinical practice;combinatorial;Communities;cost;Cytometry;design;DNA;DNA Probes;Dose;fluorescence imaging;Freezing;Genetic;Genomics;Image;imaging modality;imaging platform;In Situ;in situ sequencing;indexing;inhibitor;innovation;Investments;Isotopes;Label;Malignant Neoplasms;Maps;Mediating;Metals;meter;Methods;millimeter;Mission;Molecular;Morphology;multiplexed imaging;Mus;Nature;Noise;novel;Optics;Pathologist;Pathology;Pathway interactions;Photobleaching;Polymerase;Private Sector;protein biomarkers;Proteins;Proteomics;Protocols documentation;Public Sector;Reaction;Research Personnel;Resolution;response;Risk;RNA;RNA marker;Sampling;Scanning;Signal Transduction;single molecule;Slide;Specificity;Specimen;Stains;stem cells;Surface;Techniques;Technology;Thick;Thinness;Tissue imaging;Tissue Sample;Tissues;tool;transcriptomics;tumor;Tumor Markers;tumor progression;Visualization;Work;Yin

PROJECT_TITLE: Highly multiplexed tissue imaging with high-plex in situ signal amplification

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Genetics;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Chlamydia trachomatis is globally one of the most common sexually transmitted infections and it can cause significant reproductive harm if left untreated. Although treatable with antibiotics, managing this epidemic is complicated due to the high number of asymptomatic, chronic, and repeat infections. Our goal is to identify bacterial factors that dampen immunity and lead to persistent infection.

PI_NAMEs: STARNBACH, MICHAEL N (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: adaptive immunity;Antibiotics;Bacteria;Bacterial Genes;Candidate Disease Gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell Separation;Cells;Chimera organism;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chromosomes;Chronic;chronic depression;chronic infection;Collection;Communities;Ectopic Pregnancy;Epidemic;Epithelial Cells;experimental study;Foundations;Future;gain of function;Genes;Genetic;Genomic Library;Goals;Hela Cells;Homing;Immune;Immune Evasion;Immune response;Immunity;Immunologic Memory;immunoregulation;Impairment;In Vitro;in vivo;Individual;Infection;Infection prevention;Infertility;Left;Lentivirus Vector;Libraries;Ligands;Malignant Neoplasms;Mediating;Memory;mRNA Expression;Mus;mutant;null mutation;pathogen;pathogenic bacteria;Pathway interactions;Pelvic Inflammatory Disease;Phenotype;prevent;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteins;Public Health;Regulation;Reporting;reproductive;response;Sampling;screening;Secondary to;Sexually Transmitted Diseases;Signal Transduction;T cell response;T memory cell;T-Lymphocyte;Testing;tool;Transcript;United States;Up-Regulation;urogenital tract;Uterus;vaccine development;Vaccines;Virulence Factors;virulence gene;Virus;Work

PROJECT_TITLE: Identifying Chlamydia trachomatis factors that mediate PD-L1 upregulation

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


PHR: Relevance: We have found that antiviral lymphocytes reliably fuse with CNS resident astrocytes following viral brain infection and this proposal will determine the kinetics and longevity of fusion formation upon CNS infection. We will determine whether T cell/astrocyte fusion is a general feature of the CNS immune response using a variety of viruses with different cellular tropisms and test the requirement astrocyte antigen presentation in the fusion process. Finally, we will profile the transcriptomic changes these hybrid astrocytes undergo upon T cell fusion.

PI_NAMEs: MOSEMAN, E. ASHLEY  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adoptive Transfer;Animal Model;Animals;Antigen Presentation;Astrocytes;Biological;Biology;Brain;brain fog;CD8-Positive T-Lymphocytes;Cell fusion;Cell hybridization;cell type;Cells;Cellular Immunology;Cellular Structures;Cellular Tropism;Central Nervous System;Central Nervous System Infections;Central Nervous System Viral Diseases;Chronic;cognitive change;COVID-19;Cytoprotection;Detection;Disparate;driving force;Encephalitis;Gene Expression;Generations;Genetic;Genetic Materials;Genetic Transcription;Genome;Health;Hematopoietic;histological studies;Homeostasis;Human;human pathogen;Hybrid Cells;hybrid gene;Hybrids;Image;Immune;Immune response;Immunity;Immunologics;Impaired cognition;Infection;Infiltration;Inflammation;Inflammatory;Influenza;insight;Invaded;Kinetics;Longevity;Lymphocyte;Memory;Modeling;Mus;Nerve Degeneration;Neuroglia;Neurons;neuroprotection;novel;olfactory sensory neurons;pandemic disease;Pathologic;Process;recruit;Reporter;Respiratory Tract Infections;RNA Viruses;Role;Source;Symptoms;System;T-Lymphocyte;Testing;tissue resident memory T cell;Training;transcriptome sequencing;transcriptomics;Transgenic Organisms;Upper Respiratory Infections;Vesicular stomatitis Indiana virus;Viral;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: T cell/astrocyte fusions as a novel form of trained immunity to infection

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cerebrovascular;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE Stroke and traumatic brain injury are leading causes of disability associated to neurovascular impairments and increased cognitive decline. Glial cells are in close contact with the vasculature and after neurovascular injury, release pro-inflammatory cytokines that can be detrimental to neuronal survival. Understanding the signaling mechanisms of vascular-glial communication will advance the discovery of novel targets to prevent neurodegeneration followed by brain vascular injuries.

PI_NAMEs: COLÓN ORTIZ, CRYSTAL K (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Astrocytes;astrogliosis;Biology;Blood - brain barrier anatomy;Blood Vessels;Brain Diseases;career;career development;CASP6 gene;CASP9 gene;Caspase;Cause of Death;Cell Death;Central Nervous System;Cerebrovascular Trauma;Communication;cytokine;Demyelinations;disability;Doctor of Philosophy;Electroretinography;Endothelial Cells;Endothelium;Event;Eye;Filament;Functional disorder;Genetic;Genotype;glial activation;Glial Fibrillary Acidic Protein;Gliosis;gliovascular;Goals;Homeostasis;Human Pathology;Immunity;Immunohistochemistry;Impaired cognition;Impairment;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;Knockout Mice;Length;Light Coagulation;Link;Measures;Mediating;Mentors;Microglia;Modeling;Molecular Target;Morphology;Multiple Sclerosis;Mus;Myelin;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprotection;neurotransmission;neurovascular;neurovascular injury;neurovascular unit;new therapeutic target;novel;Optic Neuritis;Pathology;Pathway interactions;Peptide Hydrolases;pharmacologic;Phase;post stroke;Postdoctoral Fellow;prevent;Principal Investigator;Production;repaired;Research;Research Personnel;response;Retina;Retinal Edemas;Retinal Ganglion Cells;retinal neuron;Retinal Vein Occlusion;Role;Signal Pathway;Signal Transduction;stem;Stroke;TdT-Mediated dUTP Nick End Labeling Assay;Testing;Tissues;Traumatic Brain Injury;vascular injury;Veins;Vision;Visual Acuity;Visual Pathways;Western Blotting;Work

PROJECT_TITLE: How Do Astrocytes Participate in Demyelination and Myelin Repair


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Effects of Indoor Air Pollution;Human Genome;Lung;Lung Cancer;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In this revised R01 grant application we hypothesize that long-term exposure to house dust mites causes a particular subtype of inflammation and somatic mutations in the lungs, and represents a new risk factor for lung cancer in never smokers.

PI_NAMEs: BERTIN, SAMUEL P;RAZ, EYAL  (contact);WEBSTER, NICHOLAS J

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: A/J Mouse;Acceleration;airborne allergen;Allergic inflammation;Allergic Reaction;Antibodies;Applications Grants;Awareness;Biological Markers;Cancer Etiology;cancer initiation;Cancer Model;Cancer Patient;cancer type;Carcinogens;Cells;Chemicals;Chronic;Cytometry;Data;Development;Diagnosis;DNA;DNA Damage;Dose;Environmental Risk Factor;Epithelial Cells;Etiology;exposed human population;Exposure to;Genes;Genetic Predisposition to Disease;genome sequencing;Genomic DNA;Goals;Human;Immunofluorescence Immunologic;In Vitro;in vivo;Incidence;Inflammasome;Inflammation;inhibitor;Interleukin-1 beta;Intervention;intraperitoneal;Investigation;KRAS2 gene;KRASG12D;Link;Lung;Lung Neoplasms;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Measures;mouse model;Mus;Mutate;Mutation;Myeloid Cells;neutrophil;never smoker;novel;Organoids;Outcome;patient subsets;Patients;Physiological;Plasma;Population;pre-clinical;Predisposition;Preventive;Production;Prognosis;programmed cell death protein 1;Pulmonary Inflammation;Pyroglyphidae;recruit;Research Design;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Somatic Mutation;Stains;targeted treatment;Testing;Therapeutic;transcriptome sequencing;transcriptomics;Translating;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-Derived;Vaccines;whole genome;Work

PROJECT_TITLE: Chronic Exposure to House Dust Mites: A New Risk Factor for Lung Cancer in Never Smokers

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Use of some antibiotics, antihistamines, and anti-arrhythmia drugs (among others) are approved at limited doses because of a side effect called acquired long Q-T syndrome (aLQTS), which predisposes to a ventricular arrhythmia that causes sudden death. The present research aims at developing drug candidates, which can lead to effective and safe therapies to prevent aLQTS. Success in this endeavor would expand the therapeutic dose range of existing drugs, and permit promising new drugs to reach the marketplace.

PI_NAMEs: CUI, JIANMIN ;LIN, RICHARD Z (contact);ZOU, XIAOQIN

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Adrenergic Agonists;Affect;Agonist;Anti-Arrhythmia Agents;Antibiotics;Antihistamines;Arrhythmia;Atrial Fibrillation;Automobile Driving;Binding;Binding Sites;biophysical properties;Biophysics;Calmodulin;Canis familiaris;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cell Physiology;computer program;Computer software;Data;design;Docking;Dose;Dose Limiting;drug action;drug candidate;Drug Design;Drug Modelings;Drug Screening;efficacy evaluation;Electrocardiogram;Electrophysiology (science);Enhancers;Event;Exposure to;Family;FDA approved;Female;fighting;Frequencies;Goals;Heart;Heart Atrium;Heart Diseases;Heart Rate;Human;in silico;In Vitro;Individual;inhibitor;insight;Ion Channel;Lead;Ligand Binding;Long QT Syndrome;male;Measurement;Measures;member;Modeling;Molecular;Muscle Cells;Mutation;novel;novel therapeutics;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphotransferases;Play;Potassium Channel;prevent;Process;Property;Proteins;Protocols documentation;Reporting;Research;response;Risk;Role;Safety;screening;sensor;side effect;Signaling Molecule;Site;small molecule libraries;Specificity;Structure;success;Sudden Death;Syndrome;targeted agent;Testing;Therapeutic;Ventricular;Ventricular Arrhythmia;voltage;Voltage-Gated Potassium Channel;Work

PROJECT_TITLE: A full spectrum rational approach to identify antiarrhythmic agents targeting IKs Channels

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The proposed research evaluates a park-level intervention to increase moderate/vigorous physical activity and decrease sedentary time among low-income diverse children ages 6-12 yrs. A two-arm group randomized trial will randomize 24 parks for a 24 month period to compare an intervention that combines youth sports park program fee waiver plus intensive outreach versus usual outreach and usual program fee structure on changes in child physical activity.

PI_NAMEs: FRENCH, SIMONE A. (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Age;arm;Child;cohort;Communication Barriers;Communities;Community Outreach;comparison intervention;Development;Disparity;disparity reduction;Economics;Effectiveness;Enrollment;ethnic diversity;Ethnic Origin;Evaluation;Family;Fees;high risk;Income;Individual;Intervention;Intervention Studies;Light;Light Exercise;Low income;Measurement;Neighborhoods;outreach;Parents;Physical activity;Policies;programs;Race;racial diversity;Randomized;randomized trial;randomized, controlled study;Research;Research Design;Sampling;sedentary;sedentary activity;sedentary lifestyle;social;Strenuous Exercise;Structure;Time;Urban Community;waiver;Youth;youth sports

PROJECT_TITLE: Neighborhood Park Youth Sports Program Fee Waiver and Intensive Family Outreach to Promote Physical Activity in Low-Income Children Ages 6-12 Years

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Hypertension;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE  Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk, and will examine if this may be related to eating during night. Our study will identify restricted eating duration (8 hours/day) as a potential way to improve cardiovascular and metabolic health in habitual short sleepers.

PI_NAMEs: SINGH, PRACHI  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adult;Age;Ambulatory Blood Pressure Monitoring;arm;Attenuated;Awareness;Behavior;Behavioral;blood glucose regulation;Blood Pressure;blood pressure elevation;blood pressure reduction;Body mass index;cardiometabolic risk;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;circadian;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;Clinical;clinical implementation;clinical translation;Clinical Trials;Continuous Glucose Monitor;Data;Development;Diurnal Rhythm;Eating;Ensure;Exposure to;Fasting;feeding;Feeding behaviors;Feeding Patterns;Glucose;glucose metabolism;Health;High Prevalence;Homeostasis;Hour;Hypertension;Impairment;improved;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Life Style Modification;lifestyle factors;Light;Mediating;Melatonin;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Molecular;mortality;novel;obese person;Obesity;Outpatients;Participant;Periodicity;Physical activity;Physiological;Physiological Processes;Population;Prediabetes syndrome;pressure;Prevention;Prevention strategy;primary outcome;Protocols documentation;Randomized;Reporting;Research;response;Risk;Risk Reduction;Role;Safety;Sleep;Societies;System;Testing;Time;Time-restricted feeding;translational impact;United States National Institutes of Health;volunteer

PROJECT_TITLE: Cardiovascular risk and circadian misalignment in short sleepers- role of extended eating period.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]