ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Non-familial Parkinson’s disease is thought to arise from a combination of genetic and environmental factors. The experiments proposed here will enhance our understanding of the epigenetic mechanisms underlying the well-documented epidemiological link between exposure to environmental toxicants and risk of Parkinson’s disease.

PI_NAMEs: BERNSTEIN, ALISON  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: 3-Dimensional;Adult;Affect;alpha synuclein;Biological;Biological Assay;Brain;Candidate Disease Gene;candidate identification;Cell Culture Techniques;cell type;Corpus striatum structure;cytotoxicity;Data;Development;Dieldrin;Disease;Disease susceptibility;DNA Modification Process;DNMT3a;Dopamine;dopaminergic neuron;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenome;Etiology;experimental study;Exposure to;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;genome-wide;genomic locus;Goals;HDAC9 gene;High Pressure Liquid Chromatography;Immunohistochemistry;In Situ;In Vitro;in vivo;in vivo Model;Individual;Inherited;Injections;Knowledge;laser capture microdissection;late life;Link;Luciferases;male;Mass Spectrum Analysis;Mediating;Mediator;Methods;Methylation;methylation pattern;Mission;Modeling;Modification;motor behavior;mouse model;Mus;Mutation;National Institute of Environmental Health Sciences;Neurites;Neurons;neurotransmission;nigrostriatal pathway;novel;NR4A2 gene;offspring;organochlorine pesticide;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Periodicity;Persons;pesticide exposure;Phenotype;Play;pre-formed fibril;Predisposition;Presynaptic Terminals;Radioactive;response;Risk;Risk Factors;Role;Scanning;Sequencing By Hybridizations;sex;Site-Directed Mutagenesis;Specificity;sporadic Parkinson's Disease;synaptic function;synucleinopathy;System;Testing;tool;Toxic effect;Toxic Environmental Substances;toxicant;transcriptome sequencing;uptake;Western Blotting

PROJECT_TITLE: Dieldrin-induced differential gene methylation and parkinsonian toxicity (R01ES031237)


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: Veterans Affairs

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: This application requests funds to purchase a Zeiss Confocal Laser Scanning Microscope (LSM) 980 The LSM allows for high resolution and super-resolution imaging of biological specimens and will further enhance collaborations within VA-NWI and with collaborators. The system will bring new research capabilities to VA- NWI, and is a flexible system capable of meeting the diverse experimental requirements of all participating Investigators. The device will be used by 9 currently VA-funded Major Users and 1 Minor User under the supervision of an Oversight Committee. The device will significantly enhance the physical research infrastructure at VA-NWI. In doing so, the Zeiss LSM 980 will allow our researchers to perform detailed and quantitative imaging studies in a variety of samples at high resolution, greatly expanding our capabilities. This will, in turn, accelerate and augment preclinical research in areas of critical importance to Veterans health, including metabolic disease, pulmonary disorders, liver disease, and reproductive health.

PI_NAMEs: BENNETT, ROBERT G (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Alcoholic Liver Diseases;Area;Award;Biological;career;Chronic lung disease;Collaborations;Core Facility;cost;Detection;Devices;Diabetes Mellitus;Discipline;Disease;Doctor of Philosophy;Elements;experience;Fees;flexibility;Funding;Goals;Health;Healthcare Systems;imaging study;instrument;Investigation;Iowa;K-Series Research Career Programs;Laser Scanning Confocal Microscopy;Lasers;Liver diseases;Lung Diseases;Manufacturer;Marketing;Medical center;meetings;Metabolic Diseases;Microscope;microscopic imaging;Microscopy;Minor;Modality;Nebraska;non-alcoholic;non-alcoholic fatty liver disease;novel;Obesity;operation;pre-clinical research;Principal Investigator;problem drinker;Program Evaluation;quantitative imaging;Recording of previous events;Reproductive Health;Request for Applications;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Sampling;Scanning;Schedule;Scientist;Services;Sheep;Site;Specimen;Structure;superresolution imaging;Supervision;System;Technology;Time;Training;Training and Education;Universities;Veterans

PROJECT_TITLE: ShEEP Request for a Confocal Laser Scanning Microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SPLJ-C (01)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology;Nutrition;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Our goal is to develop a more effective and targeted caries preventive approach for susceptible populations. It integrates a multifunctional strategy that disrupts virulent biofilms and prevents enamel demineralization under high cariogenic conditions. The agents are low cost and approved for clinical use facilitating product development.

PI_NAMEs: KOO, HYUN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Affect;anticaries;antimicrobial;Apatites;Binding;Caries prevention;cariogenic bacteria;Cells;Clinical;comorbidity;cost;demineralization;dental biofilm;Dental caries;Dental Enamel;Dental Hygiene;Development;Dextrans;Diet;Disease;effective therapy;Ensure;Environment;Family;FDA approved;ferumoxytol;Fluorides;Funding;Gingiva;Goals;Growth;Human;Hydrogen Peroxide;improved;In Situ;in vivo;Individual;iron deficiency;Iron deficiency anemia;iron oxide nanoparticle;Medical;Microbial Biofilms;Mucous Membrane;nanocarrier;nanoparticle;novel;oral microbial community;oral microbiome;Pathogenicity;Peroxidases;Persons;Population;Poverty;Precision therapeutics;Predisposition;prevent;Preventive;product development;Property;remineralization;Rodent Model;soft tissue;Specificity;Study models;sugar;Surface;Technology;Time;Topical application;Virulent

PROJECT_TITLE: Biofilm Elimination and Caries Prevention using Multifunctional Nanocatalysts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(03)-M]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This K24 proposal addresses a critical public health need to improve treatment and prevention of pediatric venous thromboembolism (VTE), a condition that affects 1 in 200 hospitalized children. The six mentored projects will generate foundational evidence toward achieving this goal, by developing new pediatric subpopulation-specific risk assessment models and elucidating novel prognostic factors in pediatric VTE, leveraging (and collecting new patient-derived data within) recently-completed or ongoing multicenter studies in which the mentor plays a leadership role. This K24 proposal will also expand the skillsets of the mentor via the Master Mentor Program of the Johns Hopkins Institute for Clinical and Translational Research, as well as through distance learning-enabled coursework in both Bayesian methods and proteomics through Johns Hopkins University and other expert institutions/organizations, enhanced by direct interactions with internationally- recognized experts in these fields who also serve as co-investigators in the mentored projects.

PI_NAMEs: GOLDENBERG, NEIL A (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 21 year old;Acute;Acute respiratory infection;Address;Adult;Affect;age related;Alabama;Anticoagulant therapy;Anticoagulants;Anticoagulation;Bayesian Method;biobank;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;Cardiac Surgery procedures;career;Caring;Catheters;Censuses;Child;Childhood;Chronic;Clinical;Clinical Research;clinically significant;Coagulation Process;cohort;Collaborations;Collection;Committee Members;Coupled;Critical Care;Critical Illness;Critically ill children;cytokine;Cytolysis;Data;Data Collection;data repository;Data Science;Data Set;Deep Vein Thrombosis;Development;Diagnosis;Discipline;Distance Learning;Doctor of Pharmacy;Dose;Elderly;Event;Faculty;Female;Fibrinolytic Agents;Frequencies;Funding;Future;Goals;Health Care Costs;Hematology;Hemorrhage;Hospitalization;Hospitalized Child;Hospitals;improved;Incidence;indexing;Individual;Inflammatory;Inherited;inpatient service;Institution;Interdisciplinary Study;Interleukin-6;International;Intervention;Investigation;Knowledge;knowledge base;Laboratories;Leadership;Life;life span;Measures;Mechanical ventilation;Medication Errors;Medicine;member;Mentors;Mentorship;middle age;Modeling;Multicenter Studies;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Nursing Faculty;older adult;Outcome;Patients;pediatric patients;people of color;Pharmaceutical Preparations;Pharmacy facility;Phase;Plasma;Play;Population Growth;Postphlebitic Syndrome;Prevention;Prognostic Factor;Prognostic Marker;prognostic model;programs;Protein C;Protein S;Protein S Deficiency;Proteomics;Public Health;Publications;Publishing;Pulmonary Embolism;randomized trial;randomized, clinical trials;Recommendation;Recurrence;Research;Research Personnel;Research Project Grants;Risk;Risk Assessment;Risk Factors;Role;skills;Societies;Thrombin;Thrombophilia;Time;Tracheostomy procedure;Training;Translational Research;translational scientist;United States Agency for Healthcare Research and Quality;Universities;Venous Insufficiency;venous thromboembolism;Work;young adult

PROJECT_TITLE: Mentorship in Investigating Novel Risk Models and Prognostic Factors in Patients Less Than 21 Years Old with Venous Thromboembolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O1)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: The enduring mission of the University of Rochester (UR) Clinical Trials Unit (CTU) is to support and conduct clinical research on HIV/AIDS that contributes to the discovery of a preventive vaccine for HIV, as well as to the discovery of a cure for HIV, and of treatments that reduce the burden of disease due to HIV infection and its complications. The UR CTU will acheive this mission by providing exceptional scientific and administrative leadership, together with outstanding clinical trials infrastructure. It will also engage with the communities that it serves, thereby ensuring that the research it conducts is responsive to community needs.

PI_NAMEs: DEWHURST, STEPHEN ;KEEFER, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: SOUTHARD, COURTNEY MEAGAN

PROJECT_TERMS: Acceleration;Address;Affect;AIDS clinical trial group;Area;Attitude;Awareness;Biological Assay;burden of illness;Capital;Clinical Research;clinical research site;clinical translation;clinical trial enrollment;Clinical Trials;Clinical Trials Unit;Communicable Diseases;Communication;Communities;community advisory board;community engagement;Community Health Education;Cost efficiency;Coupled;Data;data management;Education;Education and Outreach;efficacy evaluation;Electronic Medical Records and Genomics Network;Ensure;Equipment and supply inventories;Evaluation;flexibility;follow-up;Guidelines;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;improved;Infrastructure;innovation;instrument;Intervention;Laboratories;Leadership;Measures;member;Mentors;Mission;National Institute of Allergy and Infectious Disease;next generation;Occupational activity of managing finances;Participant;participant enrollment;Performance;Pharmacists;Pharmacy facility;Population;Population Heterogeneity;Preventive vaccine;Procedures;programs;Protocols documentation;Qualifying;recruit;Regulation;Research;Research Activity;Research Personnel;Resource Allocation;Resource Sharing;Resources;response;Science;Scientific Advances and Accomplishments;Secure;Shipping;Specific qualifier value;Specimen Handling;success;Training;Translational Research;Universities

PROJECT_TITLE: University of Rochester HIV/AIDS Clinical Trials Unit


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

PHR: PROJECT NARRATIVE This ShEEP proposal requests a single cell analysis system comprising Namocell Pala Single Cell Dispenser and 10x Genomics Chromium Connect to serve as a shared common resource for VA-Merit and VA investigators at Veterans Administration New Jersey Healthcare System (VANJHCS). This single-cell analysis system will allow VANJHCS researchers to obtain high-resolution transcriptomic analyses of the cell populations in various diseases. Multiple VA Merit-funded research projects on melanoma, traumatic brain injury, neuroprotection, Parkinson’s disease, neuroimmunomodulation, fatty liver, hepatocellular carcinoma, and leukemia will benefit from this needed investigational platform for the careful precise study of the cell’s transcriptomic state in health and disease. This proposed system single cell analysis system will augment VANJHCS’s mission to advance Veteran healthcare by incorporating a cutting-edge, but rapidly becoming a standard investigational tool and substantially contribute to the long-term research goals of VANJHCS.

PI_NAMEs: CHOI, YUN-BEOM  (contact)

PROJECT_TERMS: Automation;Award;Bar Codes;Bile Acids;Biology;Brain;cell preparation;Cells;Cellular biology;Cessation of life;checkpoint inhibition;Chromium;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Complex;Computer software;Computers;CRISPR screen;Data;Dedications;density;Deposition;Dermal;design;Detection;Development;Diagnosis;Diagnostic;Disease;Dissociation;Ensure;Equipment;Esapent;experimental study;Extracellular Matrix;Fatty Liver;follow-up;Funding;Gene Expression;gene regulatory network;Genomics;Goals;Hand;Health;Healthcare;Healthcare Systems;Hepatic;Heterogeneity;Hour;human disease;immune cell infiltrate;Immunology;Impairment;improved;Incubated;indexing;Infection;insight;Intuition;Lasers;leukemia;Libraries;Liquid substance;Liver;Magnetism;Manuals;Manufacturer;Masks;Melanoma;Minor;Mission;Modeling;Modernization;Nerve Degeneration;Nervous System;Neuroimmunomodulation;neuroinflammation;neuroprotection;New Jersey;novel;Parkinson Disease;Pathway interactions;Population;Positioning Attribute;Preparation;pressure;Primary carcinoma of the liver cells;Productivity;Prognosis;Program Evaluation;programs;Reagent;Reproducibility;Request for Proposals;Research;Research Personnel;Research Priority;Research Project Grants;Resolution;Resources;RNA library;Robot;Running;Sampling;Scanning;screening;Side;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Skin;Sorting;stem;Sterility;System;Systems Analysis;T-Lymphocyte;Therapeutic;Time;Tissues;tool;touchscreen;transcriptome;transcriptomics;translational applications;Traumatic Brain Injury;tv watching;United States Department of Veterans Affairs;Veterans

PROJECT_TITLE: ShEEP Request for Single Cell System


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project aims to investigate cognitive and neurobiological mechanisms as predictors of a risky pattern of poly-substance use, cannabis and alcohol co-use, at different stages of adolescence using two large population studies (COGA, ABCD) and through collecting pilot data on use and co-use in a multigeneration family study (MFS). Using behavioral and neuroimaging measures, I will investigate self-regulation prior to substance initiation to understand executive functioning and impulsivity mechanisms related to future cannabis and alcohol co-use and cannabis/alcohol use disorders during adolescence. Having a broader understanding of self- regulation mechanisms will contribute to identifying at-risk children and adolescents before substance initiation, which can have immense clinical, prevention, and public health implications.

PI_NAMEs: DIB GONCALVES, PRISCILA  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 14 year old;Acute;Address;Adolescence;Adolescent;adverse outcome;Age;aged;Alcohol consumption;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;Attention;Behavior;Behavioral;Behavioral Mechanisms;Biological;Brain;brain based;Cannabis;Child;Childhood;Clinical;Cognition;Cognitive;cognitive development;cognitive function;cognitive task;cohort;Data;Data Collection;Development;Disease;drinking;Drug usage;early adolescence;early alcohol use;emotion regulation;Ensure;Environment;Environmental Risk Factor;Equation;executive function;experience;Family history of;Family Study;follow-up;Fostering;Frequencies;frontal lobe;Future;Generations;genetics of alcoholism;Goals;High Prevalence;high risk behavior;Impaired cognition;Impairment;Impulsive Behavior;Impulsivity;Individual;Informal Social Control;Injury;Intervention;Knowledge;large datasets;large scale data;Latina;Link;Longitudinal Studies;marijuana use;marijuana use disorder;Measures;Mental disorders;Mentorship;Modeling;National Institute of Drug Abuse;neurobiological mechanism;Neurocognitive;neuroimaging;neurotoxicity;offspring;Participant;Pattern;peer;Perception;polysubstance use;Population Study;preadolescence;Predisposing Factor;Prefrontal Cortex;Prevention;Prospective Studies;Public Health;Reporting;Research;Research Personnel;Research Priority;resilience factor;Rewards;Risk;Risk Factors;risk perception;risk prediction;Sampling;sociodemographics;Structure;substance use;Substance Use Disorder;Teenagers;Testing;Thick;Tobacco;Training;Translating;underage drinking

PROJECT_TITLE: Executive function and impulsivity as predictors of alcohol/cannabis co-use in adolescence: a longitudinal study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Infant Mortality;Infectious Diseases;Pediatric;Rare Diseases;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Opportunistic pathogen Group B Streptococcus (GBS) remains a leading cause of invasive disease in neonates and certain adult populations, including pregnant women. During pregnancy, asymptomatically colonizing GBS in the female genital tract can be transmitted to the fetus or newborn and can result in progression of neonatal meningitis upon GBS disruption of the blood-brain barrier (BBB); yet, the specific mechanisms by which Group B streptococcal effectors mediate toxicity and drive inflammatory responses during colonization and development of meningitis are still being elucidated. This proposal seeks to investigate how secreted bacterial proteins and/or toxins contribute to GBS pathogenesis and colonization and thwart the anti-GBS immune response.

PI_NAMEs: SPENCER, BRADY L (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Actinobacteria class;Address;Adult;alpha helix;Antibiotic Therapy;Apoptosis;ATP phosphohydrolase;Bacterial Meningitis;Bacterial Proteins;Bacterial Toxins;Biological Assay;Birth;blood-brain barrier disruption;blood-brain barrier penetration;brain tissue;Cell Death;Cells;Cerebral endothelium;Cervix Uteri;Cytolysis;cytotoxicity;Data;Development;Disease;Disease Progression;Dyes;Etiology;Exhibits;experimental study;female reproductive tract;Fetus;Firmicutes;Genes;Genome;Goals;Group B Streptococcus colonization;Hematogenous;IL17 gene;Immune Evasion;Immune response;immunogenic;in utero;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory Response;Lipid Bilayers;Mass Spectrum Analysis;Mediating;Meningitis;mortality;mouse model;Mus;mutant;Neonatal;neonatal bacterial meningitis;Neonatal meningitis;neonate;Newborn Infant;novel;opportunistic pathogen;pathogen;Pathogenesis;Population;Pregnancy;Pregnant Women;prevent;protein function;Protein Secretion;Proteins;Proteomics;Public Health;recruit;reproductive tract;response;Role;Streptococcus Group B;System;Systemic infection;T-Lymphocyte;Therapeutic;Tissues;Toxic effect;Toxin;Transmission Electron Microscopy;transmission process;Uterus;Vagina;VDAC1 gene;Virulence;Western Blotting;Woman;Work;γδ T cells

PROJECT_TITLE: Characterization of a Type VII Secretion System in Group B Streptococcus and its Role in Virulence and Immune Response

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: OVERALL - NARRATIVE Alcohol-associated liver and pancreatic diseases (ALPD) and cirrhosis are the major medical consequences of excessive alcohol drinking with high mortality around the world. The Southern California Research Center for ALPD and Cirrhosis is a regional, multi-institutional and multi-disciplinary center which continues to strive for integrated and comprehensive efforts to advance research, education, training and dissemination on the diseases. In support of its mission, Administrative Core provides administrative and logistic support; Animal Core produces innovative animal models of ALPD and cirrhosis; and Pilot Project Core provides seed funds to early-career investigators who are aspired to pursue independent ALPD research. The Center also supports four leading-edge research projects to help understand: how gut viruses contribute to alcohol- associated liver disease (AALD); how liver cancer is promoted by metabolic reprogramming in AALD; what cellular and molecular events drive excessive liver scarring in AALD; and how alcohol causes pancreas damage and inflammation via cholesterol dysregulation. High-impact outcomes from these activities are improving our understanding of the diseases and facilitating developments of new preventive and therapeutic approaches while serving as a unique national resource of technical, intellectual and collaborative services to investigators across the nation.

PI_NAMEs: TSUKAMOTO, HIDEKAZU  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: acute pancreatitis;alcohol consequences;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Animals;Automobile Driving;Award;Bacteriophages;base;Basic Science;California;career;career development;Cells;Cholesterol;Cicatrix;Cirrhosis;Clinical Research;clinically relevant;Collaborations;Communities;community center;Cytolysins;Development;Disease;Double-Blind Method;drinking behavior;Education;Educational process of instructing;Educational workshop;Enterococcus faecalis;Environment;Event;Faculty;Feasibility Studies;Fellowship;Fostering;Funding;Future Generations;Generations;Genetic Transcription;Goals;graduate student;Grant;Growth;gut bacteria;Health Personnel;Hepatitis;Home;humanized mouse;IL17 gene;improved;Inflammation;Infrastructure;innovation;insight;Institution;interleukin-23;International;Investments;K-Series Research Career Programs;Life Style;Liver;Liver diseases;Liver neoplasms;Logistics;Malignant neoplasm of liver;Medical;Medical Students;member;Mentors;Metabolic;Metabolic Diseases;microbiota;Mission;Modality;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Nature;novel;novel therapeutics;Oncoproteins;Outcome;outreach;Pancreas;Pancreatic Diseases;Pancreatitis;Patients;Phase I Clinical Trials;phase I trial;Pilot Projects;Placebo Control;Positioning Attribute;Postdoctoral Fellow;pre-clinical;premature;Preventive;programs;Publications;Publishing;Randomized;Recurrence;Reporting;repository;Research;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;self-renewal;Seminal;Service delivery model;Services;Simvastatin;Specimen;stemness;Students;summer research;symposium;Technology;Therapeutic;therapeutic development;therapeutic target;TP53 gene;Training;Training and Education;Translational Research;translational study;trial planning;Trypsinogen;tumor initiation;undergraduate student;United States National Institutes of Health;Universities;Virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (60)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

PROJECT_TERMS: Academic support;Alcoholic Liver Diseases;Animals;Area;Award;base;California;career;career development;Charge;Cirrhosis;Communication;Communities;Community Outreach;Development;Education;Educational workshop;Fellowship;Funding;Funding Agency;Funding Mechanisms;Goals;Government;graduate student;Grant;Growth;Guidelines;Hepatocyte;Individual;Institution;interest;International;Joints;Laboratories;Logistics;meeting reports;meetings;member;Mission;Monitor;Morphology;National Institute on Alcohol Abuse and Alcoholism;Newsletter;NIH Program Announcements;Nonprofit Organizations;Occupational activity of managing finances;Outcome;outreach;Pancreatic Diseases;Pilot Projects;Play;post-doctoral training;Postdoctoral Fellow;Procedures;Process;Productivity;programs;Progress Reports;Protocols documentation;Quality Control;R24;recruit;Reporting;Research;research and development;Research Personnel;Resources;Review Committee;Role;Schedule;Science;summer research;symposium;Technology;Training and Education;Training Programs;undergraduate student;United States National Institutes of Health;Vertebral column;web site

PROJECT_TITLE: Southern California Research Center for ALPD and Cirrhosis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Substance Misuse

PROJECT_TERMS: Alcoholic Liver Diseases;Area;Award;Basic Science;California;career;career development;Career Mobility;Cirrhosis;Clinical Sciences;Collaborations;Cost Sharing;Direct Costs;doctoral student;Ensure;Fees;Fellowship;Fostering;Foundations;Funding;Generations;Goals;Grant;innovation;Institution;interest;Lead;Liver diseases;Manuscripts;Mentors;Mission;Outcome;Pancreatic Diseases;Pathway interactions;Pilot Projects;Postdoctoral Fellow;pre-doctoral;programs;Publishing;Qualifying;recruit;Research;Research Personnel;Scientist;Services;Training;Training and Education;Training Programs;Translational Research;United States National Institutes of Health


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

PROJECT_TERMS: Alcohol consumption;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Alzheimer's disease model;Animal Model;Animals;ARID1A gene;Behavior;California;Cell Fate Control;cell type;Cells;Chickens;Chronic;Cirrhosis;clinically relevant;Collaborations;Consumption;CRISPR/Cas technology;CTNNB1 gene;Diet;Diffuse;Environmental Risk Factor;Ethanol;experimental study;feeding;Fetal Liver;Fibrosis;Funding;gene environment interaction;Genetic;genetic analysis;Genetic Models;Grant;Hepatocarcinogenesis;Hepatocyte;Homeostasis;Human;Hybrids;Immune;Immunocompetent;in vivo;Incidence;Inflammation;Infusion procedures;Institution;Investigation;Liver;liver cancer model;Liver diseases;Liver neoplasms;liver transplantation;Macrophage;Maps;Mediating;member;Mission;Modeling;Molecular;mouse model;Mus;Mutation;National Institute on Alcohol Abuse and Alcoholism;Neutrophil Infiltration;novel;Outcome;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Diseases;pancreatic neoplasm;Paper;Pathogenesis;Pathologic;Pathology;Patients;Pilot Projects;pre-clinical;Pre-Clinical Model;Primary carcinoma of the liver cells;problem drinker;Productivity;programs;Progress Reports;Publications;Reaction;repository;Research;Research Personnel;Resources;Rodent;Rodent Model;Sampling;Science;scientific hub;Scientist;Services;Solid;Standardization;Steatohepatitis;stemness;synergism;Techniques;Testing;therapeutic evaluation;therapeutic target;tool;Translational Research;tumor initiation;Tumor Promotion;tumorigenesis;western diet;Xenograft Model


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Microbiome;Substance Misuse

PI_NAMEs: SCHNABL, BERND G. (contact)

PROJECT_TERMS: alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Bacteria;Biopsy;California;Candida albicans;Cell Death;chromatin remodeling;Chronic;chronic alcohol ingestion;Cirrhosis;cohort;Data;Developed Countries;Digestive System Disorders;Disease;disease model;dysbiosis;Elements;Epithelial Cells;Ethanol;Etiology;Family;Feces;feeding;Functional disorder;functional genomics;fungal microbiota;fungus;Gene Modified;Genetic Transcription;Germ-Free;Gnotobiotic;Goals;Growth;gut microbiome;Health;Human;Immune response;improved;innovation;insight;Interdisciplinary Study;Intervention;intestinal epithelium;Intestinal permeability;Intestines;Laboratories;Liver;Liver diseases;LoxP-flanked allele;Mediating;Medical;metagenomic sequencing;microbiome;microbiome research;microbiota;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nature;new therapeutic target;non-alcoholic;non-alcoholic fatty liver disease;novel;nucleic acid binding protein;Organoids;Pancreatic Diseases;Patients;pharmacologic;Population;prevent;Principal Investigator;Publications;Research;Retroviridae;Role;Sampling;Signal Transduction;stool sample;Techniques;Testing;transcriptomics;United States;Universities;virome;Virus


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

PI_NAMEs: MACHIDA, KEIGO  (contact)

PROJECT_TERMS: 3-Dimensional;Acetyl Coenzyme A;Acetylation;Address;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;ARID1A gene;beta catenin;Binding;Biological Assay;California;Cell Nucleus;Chemicals;Cirrhosis;Complex;Cryoelectron Microscopy;CTNNB1 gene;Cytoplasm;Development;Distal;Endosomes;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Etiology;fatty liver disease;Fluorescence Polarization;Generations;Genetic Transcription;GTPase-Activating Proteins;Heat-Shock Proteins 70;Human;Immunofluorescence Immunologic;in silico;In Situ;In Vitro;inhibitor;knock-down;Link;Liver diseases;Malignant Neoplasms;Mediating;Membrane;Metabolic;Metabolic dysfunction;Mitochondria;Modality;Modification;Molecular;Morphology;mortality;Mus;Mutation;nonalcoholic steatohepatitis;NOTCH1 gene;novel;Nuclear;nuclear transfer;Nuclear Translocation;Oncoproteins;Organelles;Organoids;overexpression;Oxidative Phosphorylation;Patients;pluripotency factor;Primary carcinoma of the liver cells;Proteins;Pyruvate;pyruvate dehydrogenase;Recurrence;Research;Resistance;self-renewal;small molecule inhibitor;Stains;stem cells;stem-like cell;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapy resistant;TP53 gene;Treatment Efficacy;tumor initiation;UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase;Up-Regulation;Western Blotting;western diet


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease;Substance Misuse

PI_NAMEs: KISSELEVA, TATIANA  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Alcoholic Liver Diseases;Alcohols;Animal Model;antifibrotic treatment;Area;ATAC-seq;Automobile Driving;B-Lymphocytes;Bar Codes;California;Cells;Cellular Assay;Chromatin;chromatin remodeling;Chromatin Structure;Cirrhosis;Collaborations;Collagen;Collagen Type I;combinatorial;Data;design;Diagnosis;diet-induced obesity;disease model;DNA;DNA Sequence;Endothelium;Epigenetic Process;Ethanol;Extracellular Matrix;Fatty Liver;feeding;Fibrosis;Fructose;Gene Deletion;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Genes;Genetic;genetic manipulation;genetic signature;Genetic Techniques;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Glucose;Goals;Hepatic Stellate Cell;Hepatocyte;Heterogeneity;Histologic;Human;human disease;human model;human tissue;In Vitro;in vivo;insight;Institutional Review Boards;knock-down;Laboratories;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver transplantation;Metabolic Diseases;Modeling;Modification;mouse model;Mus;Myelogenous;Myofibroblast;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nuclear;Obesity associated liver disease;Pathway interactions;Patients;pharmacologic;Phenotype;Play;pre-clinical;Pre-Clinical Model;prevent;Primary carcinoma of the liver cells;Property;Regulation;Research;Role;SERPINE1 gene;single nucleus RNA-sequencing;Site;small molecule;spheroids;Steatohepatitis;synergism;T-Lymphocyte;Technology;three-dimensional modeling;transcription factor;Transcriptional Activation;Transcriptional Regulation;Transforming Growth Factor beta;Translating;Translations;Transplantation;Up-Regulation;Validation;Variant


PI_NAMEs: GUKOVSKAYA, ANNA S. (contact)

PROJECT_TERMS: Acinar Cell;Alcohol abuse;Alcoholic Pancreatitis;Autophagocytosis;California;Cell Death;cell type;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;Cirrhosis;clinically relevant;Complex;Data;Disease;Endoplasmic Reticulum;Endoplasmic Reticulum Degradation Pathway;Enhancers;Exocrine pancreas;Experimental Models;Functional disorder;Genetic;Genetic Models;Heat-Shock Proteins 70;Human;Inflammation;Inflammatory Response;inhibitor;Link;Lysosomal Storage Diseases;Lysosomes;Mediating;Mediator;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Chaperones;Molecular Target;Morbidity - disease rate;mortality;Mus;Necrosis;non-alcoholic;novel strategies;NPC1 gene;Organelles;Pancreas;Pancreatitis;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Research;response;Role;Severities;Severity of illness;Testing;Trypsinogen;Up-Regulation


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Consistent with the main objectives of MHRT T37’s, this Luna MHRT provides a 12-week international health disparities reserach training in Peru, Guatemala and Nepal to pre and postdoctoral Indigenous and UREM scholars to facilitate research careers in global health.

PI_NAMEs: ORELLANA, EDWIN ROBERTO  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Alaska Native;American Indians;Americas;Applications Grants;Asia;behavioral health;Behavioral Research;career;community based research;Country;Dedications;design;Development;Disparity;doctoral student;editorial;Educational workshop;Ethics;experience;Grant;Guatemala;Hawaii;Hawaiian;Health;Health Disparities Research;health disparity;Home;Indigenous;Institution;International;Latin America;Latin American;Learning;Manuscripts;Mentors;minority health;minority health disparity;multidisciplinary;National Institute on Minority Health and Health Disparities;Native Hawaiian;Native-Born;Nepal;Oceania;Peru;Postdoctoral Fellow;pre-doctoral;process evaluation;Program Evaluation;programs;Protocols documentation;Publications;Pueblo Race;Qualifying;Research;Research Institute;Research Methodology;Research Training;response;Samoa;Series;Site;social;Social Behavior;Structure;success;summer research;Supervision;symposium;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Washington;web site;webinar;Writing

PROJECT_TITLE: Luna International Indigenous Health Research Training Program


NIH_SPENDING_CATS: Genetics;Orphan Drug;Rare Diseases

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Calcium channel splice variation plays a vital role in normal human physiology, individual responses to drugs, and human disease. However, the tools for studying the functional effects of altered splicing are limited. Creation of a new tool for targeted splice manipulation will enable new understanding of the limitations of currently available drugs and will serve as a promising new treatment strategy for devastating genetic diseases such as Timothy Syndrome.

PI_NAMEs: DICK, IVY E (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Adult;Alternative Splicing;Antisense Oligonucleotides;autism spectrum disorder;Biophysics;Bypass;Calcium;Calcium Channel;Cardiac;Cavia;cell type;Cells;Cessation of life;channel blockers;Clinical;common treatment;Complement;Computer Models;conventional therapy;Cues;design;Developmental Delay Disorders;Dihydropyridines;Disease;DNA Sequence Alteration;Electrophysiology (science);Exclusion;Exons;experimental study;Genetic Diseases;Human;human disease;hypertension treatment;Image;improved;individual response;induced pluripotent stem cell derived cardiomyocytes;insight;Ion Channel;Length;Long QT Syndrome;Maps;Molecular Biology;Muscle Cells;mutant;Mutation;Neurologic;Neurologic Deficit;next generation;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Optics;patch clamp;patient population;patient response;patient subsets;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Point Mutation;Predisposition;Process;Protein Splicing;Proteins;Regulation;response;Risk;RNA Splicing;Role;small molecule;success;System;Techniques;Testing;Therapeutic;Timothy syndrome;tool;treatment strategy;Variant;Ventricular;Verapamil;voltage;Work

PROJECT_TITLE: Next-generation calcium channel modulators

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CLEVELAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Control of serotonergic gene expression is of general interest as serotonin has wide-ranging modulatory effects on central neural circuitry and altered serotonergic gene expression, brought about by either genetic or early life environmental stressors, has been implicated in several neuropsychiatric diseases including depression, stress-related anxiety disorders, autism, OCD, and schizophrenia. The objective of the proposed research is to introduce assays of chromatin architecture to the study of serotonin neuron development and determine whether continuously expressed developmental neuronal transcription factors control gene expression through the regulation of open chromatin states. We will investigate previously unaddressed fundamental questions about how continuously expressed neuronal transcription factors control gene expression as postmitotic neurons progress through life, which may provide fundamental knowledge about underlying mechanisms of neurodevelopmental disorders in which gene expression trajectories are thought to be altered.

PI_NAMEs: DENERIS, EVAN S (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: ADRA1B gene;Anxiety;anxiety-related disorders;Architecture;ATAC-seq;autism spectrum disorder;Binding Sites;Biological Assay;Brain;brain health;Cell Nucleus;Chromatin;chromatin remodeling;critical period;Defect;Dependence;Development;Environmental Risk Factor;environmental stressor;fetal;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;gene synthesis;Genes;Genetic;Genetic Transcription;interest;Investigation;Knock-out;Knowledge;Label;Life;Maps;Mental Depression;Molecular;Mus;neural circuit;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;neuronal excitability;Neurons;neuropsychiatric disorder;Neurotransmitters;novel;Pattern;postmitotic;postnatal;postnatal period;preservation;Property;Protocols documentation;Regulation;Regulator Genes;Research;Schizophrenia;Series;Serotonin;Sorting;spatiotemporal;Stress;SWI1;Synapses;Testing;Tn5 transposase;transcription factor;transcriptome;transcriptome sequencing;Up-Regulation;young adult

PROJECT_TITLE: Brain serotonin neuron gene regulatory networks and chromatin architecture

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Lymphatic Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE We will investigate the role of signaling pathways that promote lymphatic vessel growth during health and disease. This knowledge could reveal therapeutic strategies to treat lymphatic disorders. Thus, our work is relevant to NIH’s mission to reduce the burdens of human disease.

PI_NAMEs: SRINIVASAN, RAJANARAYANAN S (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: absorption;adrenomedullin;Affect;American;antagonist;autocrine;Binding;Biochemical;Biological Assay;Biomechanics;Blood Vessels;Body Fluids;calcitonin receptor-like receptor;Chronic;Clinical;clinically relevant;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Development;Disease;Dominant-Negative Mutation;drug repurposing;Dysplasia;effective therapy;Enhancers;Equilibrium;Etiology;Exposure to;FDA approved;Funding;G-Protein-Coupled Receptors;Gases;Gene Deletion;Gene Expression Profiling;Genetic;Growth;Growth Factor;Health;Human;human disease;Immune response;immunoregulation;improved;in vivo;Inflammation;insight;Intervention;Knowledge;Ligation;Lipids;Lymphangiogenesis;Lymphatic;Lymphatic Diseases;Lymphatic Endothelial Cells;lymphatic malformations;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;Maintenance;migration;Mission;Molecular;mouse model;Mus;Neuropilin-2;novel therapeutic intervention;overexpression;Pathologic;Pathway interactions;Patients;Pattern;peptide hormone;Physiological;Proliferating;Public Health;receptor;receptor expression;receptor-activity-modifying protein;Role;shear stress;Signal Pathway;Signal Transduction;Sphingosine-1-Phosphate Receptor;Stimulus;Testing;Therapeutic;therapeutic target;treatment strategy;United States National Institutes of Health;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;wasting;Work

PROJECT_TITLE: Defining the Mechanisms of Lymphatic Vascular Growth and Function

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Ischemic diseases - such as heart attacks – occur when blood flow decreases or stops, causing damage to organs and tissues. These diseases afflict millions of people in the United States and current treatments are inadequate to restore the small blood vessels in the affected tissues. Here, we propose studies to develop a new strategy to make the transplantation of endothelial cells (the cells that line all the blood vessels in the body) more effective for the treatment of ischemic diseases.

PI_NAMEs: MELERO-MARTIN, JUAN M (contact)

PROJECT_TERMS: Ablation;Affect;Aftercare;Apoptosis;Autophagosome;BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like;Biogenesis;Blood flow;Blood Vessels;Cell Line;Cell Therapy;cell type;Cells;Centrifugation;Clinical Trials;Complement;critical limb Ischemia;Cytolysis;Cytoprotection;Data;Disease;Echocardiography;effective therapy;efficacy evaluation;Endocytosis;Endothelial Cells;Endothelium;Engraftment;Evaluation;experience;Fibrosis;Genetic;Goals;heteroplasmy;Human;imager;Immunodeficient Mouse;Impairment;implantation;improved;in vivo;Infarction;insight;Ischemia;Lasers;limb ischemia;Measures;Mediating;Mediator;Medicine;mesenchymal stromal cell;Methods;Microcirculatory Bed;Mitochondria;Mitochondrial DNA;Modeling;Mus;Myocardial Infarction;Myocardial Reperfusion Injury;Nanotubes;Natural regeneration;novel strategies;Nude Rats;Operative Surgical Procedures;Organ;oxidation;Parkin;Pathway interactions;Perfusion;Persons;Pharmaceutical Preparations;PINK1 gene;Pinocytosis;pressure;Process;Property;Publishing;Rattus;Recovery;Research;revascularization;Role;Supporting Cell;TBK1 gene;Technology;Testing;therapy development;Tissues;Transplantation;United States

PROJECT_TITLE: Enhancing endothelial cell engraftment via transplantation of exogenous mitochondria

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The over-arching goal of the proposed research is to translate a new MRI technology, hyperpolarized (HP) MR, to the clinic in the setting of large-field-of-view (FOV) MRI, which utilizes both the agents HP [1-13C] pyruvate and [2-13C] pyruvate in metastatic prostate cancer patients. Prostate cancer demonstrates tremendous biologic diversity, and there is an urgent need to develop more sensitive and specific imaging biomarkers to characterize the disease. We aim to develop a large-body transmit/receive system and pulse sequences for large FOV and apply them to a cohort of prostate cancer patients: this work will aid in future patient-specific treatment planning, facilitate earlier assessment of response to therapy, and facilitate the development of novel experimental strategies for cancer treatment.

PI_NAMEs: CUNNINGHAM, CHARLES H.;HRICAK, HEDVIG ;KESHARI, KAYVAN R (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Abdomen;Address;androgen deprivation therapy;androgen independent prostate cancer;animal imaging;Animals;Benchmarking;Biodiversity;Biological Markers;Biology;Biopsy;bone;Brain;Breast;Cancer Patient;cancer site;cancer therapy;Citric Acid Cycle;Clinic;Clinical;Clinical assessments;cohort;Collaborations;Computer software;Data;design;Development;Disease;Disseminated Malignant Neoplasm;Echo-Planar Imaging;first-in-human;follow-up;Foundations;Future;Glycolysis;Goals;Heart;Histologic;Human;Human body;human study;Image;image reconstruction;imaging biomarker;imaging capabilities;imaging modality;improved;in vivo;individualized medicine;Industrialization;industry partner;Infrastructure;Infusion procedures;innovation;interest;Label;Lesion;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolism;Metastatic Prostate Cancer;Methods;molecular imaging;Monitor;Motivation;Mutation;non-invasive imaging;non-invasive monitor;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathology;patient population;Patients;Perfusion;Pharmacotherapy;Phenotype;Physiologic pulse;Population;Prostate;PSA level;Pyruvate;Pyruvate Metabolism Pathway;Radioactive Tracers;Research;Research Personnel;response;Role;Scientist;Sensitivity and Specificity;serum PSA;Site;software development;Support System;Surface;System;Systems Biology;Techniques;Technology;Therapeutic Intervention;Time;tool;Translating;transmission process;Transrectal Ultrasound;treatment effect;treatment planning;treatment response;tumor;tumor metabolism;Up-Regulation;Validation;virtual;Visualization;Work

PROJECT_TITLE: Development of large-field-of-view hyperpolarized MRI


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because many genetic, infectious and neoplastic diseases are driven by changes in PI(4,5)P2 levels. We seek to identify the basic mechanisms whereby healthy cells control PI(4,5)P2 levels and couple them to multiple, parallel PI(4,5)P2-dependent membrane functions, revealing basic cellular mechanisms underpinning these diseases. Therefore, the research is relevant to NIH's and NIGMS's central mission of seeking fundamental knowledge about living systems and life processes that lay foundations for advances in disease treatment and prevention.

PI_NAMEs: HAMMOND, GERALD R (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adverse effects;Affect;Cell Culture Techniques;Cell membrane;Cell Membrane Permeability;Cells;Coupled;Couples;Coupling;Cytoskeleton;Dependence;Disease;disease phenotype;Excision;Failure;Foundations;Funding;Genetic;genetic manipulation;Goals;Health;human disease;Individual;Inositol;Knowledge;Life;lipid transfer protein;Lipids;Malignant Neoplasms;Membrane;Mendelian disorder;Metabolism;Mission;Mitochondria;Molecular;National Institute of General Medical Sciences;neoplastic;Organelles;Organism;Pathogenesis;Pathogenicity;Phosphatidylinositols;phosphoinositide-3,4-bisphosphate;Phosphoric Monoester Hydrolases;Physiological Processes;PIK3CG gene;prevent;Prevention;Process;protein activation;Proteins;Public Health;receptor;recruit;Regulation;Research;Signal Transduction;spatiotemporal;Specificity;synthetic biology;Therapeutic;Therapeutic Intervention;Time;tool;United States National Institutes of Health

PROJECT_TITLE: Directing Membrane Function with Inositol Lipids in Health and Disease

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Food insecurity is a major public health problem that affects 1 in 7 Americans, disproportionately impacts low- income and minority households, and is associated with poor cardiovascular health. The proposed Mentored Career Development Award will provide further understanding of the relationship between food insecurity and cardiovascular disease allowing us to tailor an innovative tool for primary care practices to address food insecurity and improve cardiovascular health. This research program could improve the care of low-income and vulnerable patients by reducing the negative impact of food insecurity on cardiovascular health.

PI_NAMEs: PALAKSHAPPA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Affect;Age;American;Award;Awareness;Behavior;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;career development;Caring;catalyst;Chronic;Clinic;Clinical;clinical care;Clinical Informatics;Clinical Investigator;Clinical Research;Communities;community organizations;Competence;Complex;Data;design;Development;diabetes risk;dietary;Disease;Disparity;disparity reduction;Electronic Health Record;Environment;Equation;experience;Food;food insecurity;food security;Foundations;Future;Goals;Health;health difference;Health system;Healthcare;Household;Hypertension;implementation research;improved;individual patient;innovation;Intervention;K-Series Research Career Programs;Knowledge;Lead;Life;Low income;Low Income Population;Medical Care Team;medical schools;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Minority;mobile computing;Modeling;mortality;National Health and Nutrition Examination Survey;National Heart, Lung, and Blood Institute;novel;Outcome;Pathway interactions;Patient Care;patient engagement;patient navigator;patient population;patient retention;patient screening;Patients;Persons;poor health outcome;Population;population health;Pragmatic clinical trial;pragmatic randomized trial;pragmatic trial;Prevalence;Primary Care;primary care practice;Principal Investigator;Process;Program Development;programs;Public Health;Qualifying;Randomized;randomized effectiveness trial;randomized trial;Recommendation;recruit;Reduce health disparities;Research;Research Personnel;Resources;Risk Factors;Senior Scientist;Site;skills;social;social health determinants;Solid;Statistical Models;Surveys;Tablets;Testing;Time;tool;Training;usability;user centered design;Vulnerable Populations;Work

PROJECT_TITLE: Mobile Technology for Primary Care to Address Food Insecurity and Improve Cardiovascular Health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed project will be the first to investigate the impact of predictability of the word learning environment on fast-mapping, retention, and generalization of newly learned words in young children with ASD compared to cognitively matched NT peers. This project will employ two brief eyegaze experiments which will evaluate performance on a word-learning task in which words will be taught in both predictable and unpredictable sequences and tested as they appeared in training immediately (fast-mapping) and after a 5-minute delay (retention) as well as for generalization to shape-matched objects. Finally, individual differences (e.g., extant language and cognitive abilities) associated with greater disruption of learning from unpredictable stimuli will be investigated.

PI_NAMEs: MATHEE-SCOTT, JANINE R (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 4 year old;Address;adult with autism spectrum disorder;Area;autism spectrum disorder;autistic;autistic children;Characteristics;Child;clinically significant;Cognition;Cognitive;cognitive ability;Data;educational atmosphere;Educational process of instructing;Environment;experience;experimental study;Hyperplasia;Impairment;Individual Differences;individual variation;individuals with autism spectrum disorder;innovation;insight;Knowledge;Label;Language;Language Delays;Language Development;Learning;learning ability;Linguistics;Maps;Measures;Methodology;Methods;Modeling;non-verbal;novel;Parents;Pattern;peer;Performance;Phenotype;Population;Research Personnel;Severities;Shapes;social;standardize measure;statistical learning;statistics;Stimulus;success;Testing;theories;Toddler;Training;treatment strategy;United States;Update;Vocabulary;Weight;word learning

PROJECT_TITLE: Prediction and Word Learning in Young Children with Autism Spectrum Disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Social media are a major marketing platform for reaching youth and vulnerable populations traditionally experiencing tobacco-related disparities with little cigar and cigarillo promotion. The goal of this project is to assess the intended and unintended effects of exposure to commercial and influencer social media content about cigar products on Twitter and Instagram with tobacco and marijuana product use and sales to inform future tobacco use prevention, education, and marketing regulation efforts.

PI_NAMEs: KOSTYGINA, GANNA  (contact)

PROGRAM_OFFICER_NAME: BLAKE, KELLY D

PROJECT_TERMS: Advertising;Affect;African American;African American population;analytical method;Area;Attitude;base;Behavior;Behavioral;Belief;Biometry;Characteristics;Cigar;Cigarette;cigarette smoking;cigarillos;Collaborations;collaboratory;Color;Commercial Catalogs;Communications Media;Communities;computer science;Consumption;contextual factors;Data;Data Analyses;Data Set;digital;Disparity;Economics;Education;experience;Exposure to;food marketing;Future;General Population;Geographic Locations;Goals;Health;High School Student;hookah;Imagery;Individual;innovation;insight;Instagram;Knowledge;Latino Population;Link;Location;Longitudinal cohort;Marijuana;marijuana use;Marketing;Measures;media use;Methodology;Misinformation;Modeling;Outcome;Outcome Measure;Patient Self-Report;Perception;Pharmaceutical Preparations;Policies;Population;Prevalence;Price;Public Opinion;public policy on tobacco;Regulation;Research;Research Methodology;Risk Factors;Role;Sales;Scientific Advances and Accomplishments;Smoker;Smoking;Smoking Behavior;social;social media;social networking website;Source;Subgroup;Surveys;Time;Tobacco;tobacco advertising;tobacco control;Tobacco Industry;tobacco prevention;tobacco products;Tobacco use;tool;Twitter;United States;Vulnerable Populations;Youth

PROJECT_TITLE: Assessing the Effects of Cigar and Cigarillo Social Media Promotion on Tobacco and Marijuana Use

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: NARRATIVE We showed that activation of -catenin in osteoblasts leads to MDS and occurs in 38% of MDS patients. ATRA is reported to inhibit -catenin signaling. Our preliminary data show that inhibition of -catenin signaling in 14 such patients by ATRA improves hematologic phenotype and treats MDS in mice. We aim to dissect molecularly and genetically in mouse and xenograft models the specificity of the inhibitory action of ATRA in this type of osteoblast-induced MDS to explore its potential use in these patients.

PI_NAMEs: KOUSTENI, STAVROULA  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute Promyelocytic Leukemia;Agreement;Anabolism;beta catenin;bone cell;Bone Marrow;Cells;Clinical Trials;Clonal Evolution;Complex;Cytogenetics;Data;Development;Disease;Disease Outcome;Dissociation;DNA;Dysmyelopoietic Syndromes;FDA approved;Genetic Recombination;Genetic Transcription;Goals;granulocyte;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;Human;human disease;improved;In Vitro;Interruption;Mesenchymal Stem Cells;MicroRNAs;Molecular;mouse model;Mus;Mutation;Myeloid Leukemia;Myeloproliferative disease;novel;novel therapeutic intervention;Osteoblasts;osteoprogenitor cell;Pathway interactions;patient population;Patients;pharmacologic;Phenotype;Population;prevent;progenitor;Protein Tyrosine Phosphatase;PTPN11 gene;Reporting;Retinoic Acid Receptor;Role;Severities;Shwachman-Diamond syndrome;Signal Induction;Signal Pathway;Signal Transduction;Specificity;Stromal Cells;Syndrome;Testing;Transplantation;Tretinoin;Xenograft Model

PROJECT_TITLE: Cellular and Molecular mechanisms of ATRA inhibition of osteoblast-induced MDS development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Sepsis remains the leading cause of death in critically ill patients. The proposed research is relevant to public health because the elucidation of Lipocalin 10 (Lcn10) in sepsis-induced vascular leak is ultimately expected to open new avenues and develop novel therapeutic tools for increasing the expression levels of Lcn10 in septic endothelial cells, thereby resulting in a decreased vascular leakage and an improved survival. Thus, the proposed project is relevant to the part of NIH’s mission that pertains to advancing fundamental knowledge and translational study that will help to reduce the burdens of human disability.

PI_NAMEs: FAN, GUO-CHANG  (contact)

PROJECT_TERMS: Actin-Binding Protein;Actins;Acute Respiratory Distress Syndrome;Adherens Junction;animal mortality;Animals;Antibiotic Therapy;Antisepsis;autocrine;Blood capillaries;Blood Vessels;Cardiac;cardiac depression;Cardiac Edema;Cardiac Myocytes;Cardiovascular system;Cause of Death;cecal ligation puncture;Cell Physiology;cell type;Cells;Cessation of life;cofilin;comparison control;Coronary;Critical Care;Critical Illness;Cytoskeleton;Data;Development;disability;Edema;Endothelial Cells;Endothelium;Endotoxins;Extravasation;Fibroblasts;Future;Heart;Heart failure;heart function;Heart Injuries;Homologous Gene;Human;improved;In Vitro;in vivo;Inflammatory;Injections;Intensive Care Units;Intercellular Junctions;knock-down;Knock-out;Knockout Mice;Knowledge;Leucocytic infiltrate;Link;Liquid substance;Lung;Measures;Mediating;Mediator;member;Microfilaments;Mission;Monitor;monolayer;mortality;mouse model;Mus;Myocardial;Myocardial dysfunction;novel;novel therapeutics;Operative Surgical Procedures;Organ failure;overexpression;Partner in relationship;Pathway interactions;Patients;Permeability;Phosphoric Monoester Hydrolases;Physiology;Play;polymicrobial sepsis;potential biomarker;pre-clinical;Protein Dephosphorylation;Protein Secretion;Proteins;Public Health;Pulmonary Edema;Recombinants;Regulation;Research;Resistance;Resuscitation;RNA analysis;Role;Sepsis;septic;septic patients;Septic Shock;Small Interfering RNA;survival outcome;Survival Rate;Testing;Therapeutic;Tight Junctions;Time;Tissues;tool;transcriptome sequencing;Transgenic Mice;Translating;translational study;United States National Institutes of Health;Up-Regulation;Vascular Permeabilities;Wild Type Mouse;Work

PROJECT_TITLE: Lcn10 in Sepsis-Induced Vascular Leakage and Heart Failure

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE The goal of this work is to provide proof-of-concept that coreceptor tuning enhances the therapeutic efficacy and safety of antigen-based immunotherapy for the purpose of suppressing ongoing T cell-mediated autoimmunity long-term.

PI_NAMEs: TISCH, ROLAND M (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: acquired immunity;adaptive immunity;Adjuvant;Affect;Antibodies;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B-Lymphocyte Differentiation Antigens;B-Lymphocytes;Binding;CD4 Antigens;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Clinic;Clinical;Clinical Research;Combination immunotherapy;combinatorial;Conceptions;Data;Diabetes Mellitus;diabetes mellitus therapy;Diabetes prevention;diabetogenic;Disease Progression;Dose;Down-Regulation;effector T cell;Equilibrium;Eragrostis;Etiology;Event;FOXO1A gene;FOXP3 gene;Frequencies;Genetic Transcription;Goals;Human;humanized mouse;immune function;Immune mediated destruction;Immunotherapy;in vivo;Inbred NOD Mice;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Interleukin-10;Mediating;Modeling;mouse model;Nature;novel;novel strategies;Pathogenicity;Pathology;peptide vaccination;Peptides;pre-clinical;prevent;Prevention;Property;receptor;Regulatory T-Lymphocyte;Safety;Self Administration;Self Tolerance;Signal Transduction;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;transcription factor;Treatment Efficacy;Up-Regulation;Vaccination;Work

PROJECT_TITLE: Enhancing antigen-based therapy for T1D by T cell coreceptor tuning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-D(02)]


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE O-GlcNAc transferase (OGT), one of the most conserved proteins in mammals, is a proposed target for the treatment of cancer and cardiometabolic diseases. The work proposed here will provide tools, technologies, and knowledge that will provide a foundation for exploiting OGT as a therapeutic target.

PI_NAMEs: WALKER, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Address;Affect;Asparagine;Aspartate;Binding;Biochemistry;Biological Process;Biology;cancer therapy;cancer type;Cardiometabolic Disease;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Combined Modality Therapy;Complications of Diabetes Mellitus;conditional knockout;Cytoplasm;Cytoplasmic Protein;design;Drug Targeting;experimental study;Foundations;Funding;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genomics;glycosylation;glycosyltransferase;Growth;host cell factor C1;Human;inhibitor;insight;Insulin Resistance;knock-down;Knowledge;Length;Link;Location;Malignant Neoplasms;Mammals;Mediating;Metabolic Diseases;Methods;Mitochondrial Proteins;nanomolar;novel;Nuclear Proteins;O-GlcNAc transferase;Other Genetics;Pathway interactions;Permeability;Phenotype;Physiological;Physiology;Predisposition;Process;Proteins;Proteomics;Role;scaffold;Scientific Advances and Accomplishments;Side;small molecule inhibitor;Supporting Cell;System;Technology;Testing;Therapeutic;therapeutic target;tool;Variant;Vertebral column;Work

PROJECT_TITLE: Defining OGT's Essential Functions to Guide Therapeutic Approaches

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE: This research proposal is relevant to public health because the prevalence of type-2 diabetes is rising and despite significant advances in medicine, still represents a major economic and social burden. Cellular mechanisms involved in the development of diabetic cardiovascular disease are still poorly understood. This project will investigate dysfunctional cellular signaling pathways that increase the chloride channel, anoctamin-1, in arterial smooth muscle cells and identify promising protein targets for therapeutic intervention.

PI_NAMEs: LEO, M. DENNIS MARCUS  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;Animals;Arterial Occlusive Diseases;Arteries;Biological Assay;Biotinylation;Blood flow;Blood Vessels;Calcium;Calcium Channel;Calcium Signaling;Cardiovascular Diseases;cardiovascular disorder risk;Cells;cerebrovascular;Chloride Channels;chromatin immunoprecipitation;chromosome conformation capture;Co-Immunoprecipitations;constriction;Coronary;Coupled;Data;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;diabetic cardiomyopathy;Diabetic mouse;Diagnosis;Disease;Dyslipidemias;Economics;Electrophoretic Mobility Shift Assay;Electrophysiology (science);Enzymes;Factor Analysis;Gene Expression;Genes;Genetic Predisposition to Disease;Genetic Transcription;glycogen synthase kinase 3 beta;glycogen synthase kinase 3 beta inhibitor;Goals;Hyperglycemia;Immunofluorescence Immunologic;in vivo;Incidence;Insulin;Insulin Resistance;Integral Membrane Protein;Ion Channel;kidney vascular structure;Knockout Mice;Lower Extremity;Luciferases;Mediating;Medicine;Membrane;Membrane Potentials;Messenger RNA;Metabolic;Morbidity - disease rate;mortality;Muscle Cells;Myography;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Organ;Oxygen;patch clamp;Pathologic;Patients;Peripheral arterial disease;Persons;physical inactivity;pressure;Prevalence;Prognosis;promoter;Proteins;Public Health;Repressor Proteins;Research Proposals;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Snails;social;stem;Surface;System;targeted treatment;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;transcription factor;Transcription Repressor;Vascular Diseases;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Western Blotting

PROJECT_TITLE: Chloride channels in diabetic vascular disease

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as the receptor for cell entry. We propose to study the host factors that regulate the transcription of ACE2, and to analyze the function of virus variants that adapt to replication in cells expressed low levels of ACE2. Upon conclusion, this research will extend our knowledge of host factors essential for SARS-CoV-2 infection and provide new targets for the treatment of SARS-CoV-2 infection.

PI_NAMEs: ZHU, YIPING  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Amino Acid Substitution;Antibodies;antiviral drug development;Architecture;Binding;Binding Sites;Cell Line;Cells;Chromatin;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;COVID-19;COVID-19 treatment;Data;Databases;Dependence;Deposition;Development;differential expression;DNA Binding;DNA Sequence Alteration;Epigenetic Process;Genetic Transcription;genome-wide;global health;hepatic nuclear factor 1;Human;human tissue;India;innovation;Integration Host Factors;Kidney;Knock-out;Knowledge;Large Intestine;Lung;Maps;Mexico;Molecular;Monkeys;Mutation;novel;Nucleocapsid;Orthologous Gene;Play;prevent;Production;Promoter Regions;protein protein interaction;receptor;Receptor Cell;recruit;Regulation;Research;Residual state;SARS-CoV-2 infection;Testing;therapeutic development;therapy design;Tissues;TNF receptor-associated factor 3;Transcriptional Activation;Transcriptional Regulation;vaccine access;validation studies;Variant;Viral;Viral Pathogenesis;Virion;Virus;Virus Diseases

PROJECT_TITLE: Transcriptional regulation of ACE2 and the adaption of SARS-CoV-2

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

PHR: PROJECT NARRATIVE Patients with early-stage bladder cancer have seen few meaningful treatment advances in the last 20 years. Focusing on two groups with particularly acute need for new treatment options, we aim to discover and validate genomic contributors to disease progression and chemotherapy resistance, and to preclinically examine HER2-directed antibody-drug conjugate therapy as an alternative to platinum-based cytotoxic chemotherapy. Our long-term translational goal is to use integrated clinical and laboratory studies to develop more effective and less toxic treatments for patients with localized bladder cancer, a frequently fatal yet understudied disease.

PI_NAMEs: PIETZAK, EUGENE  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acute;Adjuvant Chemotherapy;Antibody-drug conjugates;Bacillus Calmette-Guerin Therapy;BCG Live;biobank;Bladder;Bladder Neoplasm;cancer cell;Cancer Patient;cell free DNA;Cell Separation;Chemoresistance;chemotherapy;Cisplatin;Clinical;Clinical Research;Clinical Trials;cohort;curative treatments;Cystectomy;Cytotoxic Chemotherapy;Data;Dependence;Diagnosis;Disease;Disease Progression;DNA Damage;ERBB2 gene;ERCC2 gene;exome sequencing;Frequencies;Funding;Gene Amplification;Gene Mutation;Genes;Genetic;genomic profiles;genomic profiling;Genomics;Germ Lines;Goals;Heterogeneity;high risk;Immunotherapy;intravesical;Laboratory Study;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediator;Modality;Modeling;Molecular;Molecular Profiling;Molecular Target;Multi-Institutional Clinical Trial;Muscle;muscle invasive bladder cancer;Mutation;mutational status;Neoadjuvant Therapy;new therapeutic target;non-muscle invasive bladder cancer;novel;Nucleotide Excision Repair;Oncogenic;Oncology;Operative Surgical Procedures;Organoids;Outcome;overexpression;Pathogenesis;Pathway interactions;patient subsets;Patients;Platinum;pre-clinical;predicting response;prevent;progression risk;prospective;Protein Overexpression;Radical Cystectomy;Recurrence;Recurrent disease;Research;Resistance;response;Risk Reduction;Role;Sampling;Secondary to;Somatic Mutation;Testing;therapy development;therapy resistant;translational goal;treatment response;treatment strategy;tumor;tumor heterogeneity;Urine;Xenograft Model

PROJECT_TITLE: Defining Mechanisms of Progression and Treatment Resistance in Localized Bladder Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Whereas the impact of risk variants and environmental stress associated with brain disease occurs in aggregate, the interactions between the myriad variants and stressors are undetermined, thereby limiting the translation of highly complex genetic insights into medically actionable information. We propose to combine functional genomics, genetic screening, and genome engineering approaches to explore the complex genetics of psychiatric and neurodegenerative disease risk. By better understanding the interactions between genetic variants and stress, we hope to improve diagnostics, predict clinical trajectories, and develop novel therapeutic interventions.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER;HUCKINS, LAURA MARIANNE (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Affect;Alleles;American;Astrocytes;biobank;Biological;bisphenol A;Brain;brain cell;Brain Diseases;causal variant;Cell Physiology;cell type;Clinical;clinical predictors;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Data;Data Set;Diagnosis;Diagnostic;Disease;disorder risk;Dissection;Engineering;Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Etiology;falls;follow-up;functional genomics;FURIN gene;gene environment interaction;gene interaction;Gene Targeting;Genes;Genetic;genetic association;genetic disorder diagnosis;genetic risk factor;Genetic Screening;genetic variant;Genome engineering;genome wide association study;Genomics;Goals;Healthcare;Heritability;Human;Hydrocortisone;improved;In Vitro;insight;Interferon alpha;Interleukin-6;Lead;Link;Measures;Medical;Mental disorders;Microglia;MicroRNAs;Modeling;neglect;Nerve Degeneration;Neurodegenerative Disorders;neurogenomics;Neuroglia;Neurons;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Outcome;Pathway interactions;Patients;phenome;Phenotype;phthalates;physiologic stressor;Physiological;polygenic risk score;population based;precision medicine;psychogenetics;response;risk variant;Schizophrenia;Severities;Stimulus;Stress;stressor;synaptic function;Testing;Therapeutic Intervention;therapeutic target;trait;transcriptome;transcriptomics;translational impact;Translations;treatment response;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traits


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Southern California Center for Children’s Environmental Health Translational Research is to reduce the burden of childhood air pollution-related diseases by building an innovative framework for multidirectional engagement in which communities, government and civil society use science to develop solutions, with a focus on environmental justice communities.

PI_NAMEs: JOHNSTON, JILL E;KAMAI, ELIZABETH MARY;MCCONNELL, ROB S (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Academia;Address;Adverse effects;Affect;Air Pollution;Area;artist;Arts;base;California;career development;catalyst;Center for Translational Science Activities;Child;Child Health;Childhood;Cities;civil society;Collaborations;Color;Communication;Communities;community burden;community collaboration;community engagement;community partners;community science;Country;Creativeness;Data;Decision Making;design;Development;Disease;Education;Educational workshop;empowerment;Environment;Environmental Health;environmental justice;Evaluation;Faculty;Foundations;Gases;Goals;Government;Government Officials;Grant;Health Disparities Research;health science research;implementation science;improved;Industrialization;innovation;International;Intervention;Journalism;Knowledge;marginalized community;Metabolic;Methods;Mission;Modeling;Movement;multidisciplinary;National Institute of Environmental Health Sciences;Neighborhoods;neurodevelopment;next generation;novel strategies;Obesity;Oils;Outcome;Pathway Analysis;peer;Pilot Projects;Policies;Policy Maker;Postdoctoral Fellow;Production;Professional Organizations;Program Development;programs;Public Health;Quasi-experiment;recruit;Research Personnel;Research Support;Resources;respiratory health;Rest;Schools;Science;Scientist;social;social media;Societies;Sociology;Strategic Planning;symposium;System;Techniques;Testing;tool;Training;Translating;translational health science;Translational Research;translational scientist;Translations;Transportation;trend;undergraduate student;Universities;urban area;urban planning;Vision;Wildfire;Work;working group;Youth


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

PI_NAMEs: MCCONNELL, ROB S (contact)

PROJECT_TERMS: Advisory Committees;Air Pollution;Area;Award;built environment;burden of illness;California;career;career development;Center for Translational Science Activities;Child;Child Health;Child Support;Childhood;Collaborations;Communication;Communities;community empowerment;community engagement;community organizations;community science;Consultations;Data;Decision Making;design;Development;Discipline;Education;Educational workshop;Effectiveness;Ensure;Environment;Environmental Health;environmental justice;Evaluation;Exercise;Fostering;Funding;Future;health science research;implementation science;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Knowledge;Leadership;meetings;member;Mission;Modeling;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;Needs Assessment;Neighborhoods;novel strategies;organizational structure;Pathway Analysis;Performance;Periodicals;Pilot Projects;Policies;Policy Maker;Productivity;Program Development;programs;Recommendation;Reproducibility;Research;Research Activity;Research Personnel;Resources;response;Role;Science;Series;Services;social media;Societies;Sociology;Structure;success;symposium;tool;translational health science;Translational Research;translational research program;Translations;Universities;Update;urban planning;Vision;web site;webinar;Work;working group;Youth

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE  This proposal focuses on the fungus Cryptococcus neoformans, responsible for hundreds of thousands of deaths yearly, and towards which there is no adequate treatment. We aim to characterize a gene that, in its absence, renders the fungus sensitive to a variety of antifungals and also alters the fungal-host interactions, which are important for the progression of the disease. Elucidation of the function of this gene will result in a better understanding of antifungal resistance and fungal pathogenesis, opening new areas of research that could potentially result in improved therapeutics. Therefore, given the high medical burden of this yeast, and the limited and suboptimal treatments, this research is relevant to NIH’s public health mission and a specific priority for various institutes such as NIAID and NHLBI. Lastly, because this gene resembles an ABC transporter, which play a significant role in resistance to antimicrobials and anticancer treatments, this work will also contribute to basic cellular knowledge, impacting the research of ABC transporters and antimicrobial resistance in general.

PI_NAMEs: SANTIAGO-TIRADO, FELIPE H (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Africa;Amino Acid Sequence;Animals;anti-cancer treatment;anti-fungal agents;Antimicrobial Resistance;Applications Grants;Area;ATP-Binding Cassette Transporters;Attenuated;attenuation;Binding;Biological Assay;Cell membrane;Cell model;Cell Physiology;Cell surface;Cells;Cessation of life;Clinical;Clinical Research;Clinical Treatment;Complex;cost;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Data;Death Rate;Developing Countries;Development;Dimerization;Disease;Disease Management;Disease Outcome;Disease Progression;Drug resistance;effective therapy;efflux pump;Endoplasmic Reticulum;Ergosterol;Europe;Exhibits;Family;Fluconazole;Fluconazole resistance;Fungal Drug Resistance;Fungal Genes;fungus;Future;gene function;Genes;Goals;Homologous Gene;human disease;Hypersensitivity;Immune response;Immunocompromised Host;improved;in vivo;Incidence;Individual;Infection;insight;Intervention;Knowledge;Left;Light;low income country;Lung;Macrophage;Medical;Mission;Modeling;mouse model;mutant;Mycoses;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;novel;Organism;Outcome;overexpression;Pathogenesis;pathogenic fungus;Pathogenicity;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phenotype;Plasma;Play;Population;Predisposition;prevent;Process;Protein Sequence Analysis;Public Health;Regulation;Relapse;Research;resistance gene;Resistance profile;response;Role;Southeastern Asia;Steroids;synergism;Testing;Therapeutic;Toxic effect;Transmembrane Transport;United States National Institutes of Health;Virulence;Work;Yeasts

PROJECT_TITLE: The role of a pleiotropic drug resistance (PDR) transporter in the cryptococcal-host interactions

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

PROJECT_TERMS: Address;Air Pollution;Area;Award;Behavioral;Biometry;California;career;career development;catalyst;Center for Translational Science Activities;Child;Child Health;Clinical Sciences;Collaborations;Communication;Communities;community partners;community science;Country;design;Development;Development Plans;Discipline;Disease;Education;Educational workshop;Environment;Environmental Health;environmental health disparity;environmental justice;Epidemiology;Faculty;Fostering;Funding;Goals;Grant;Health;health science research;implementation science;Infrastructure;innovation;Institution;interest;International;investigator training;Knowledge;Medicine;member;Mentors;Methods;Modeling;multidisciplinary;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;novel;novel strategies;Outcome;Participant;Pathway Analysis;peer coaching;Peer Review;Pilot Projects;Policies;Population Sciences;Positioning Attribute;Productivity;Program Development;programs;recruit;Research;Research Personnel;Resources;Science;Scientist;Series;Site;skills;Societies;Sociology;Strategic vision;success;symposium;tenure track;Testing;Time;Training;training opportunity;translational approach;translational health science;translational impact;Translational Research;Travel;Vision;Visit;working group;Youth

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Animal models of SARS-CoV-2 infections are critical for the discovery of therapeutics, as well as understanding SARS-CoV-2-induced acute respiratory distress syndrome and extra-pulmonary complications. Unfortunately, current mouse models for COVID-19 do not allow to study the mechanism of organ-specific pathology. The proposed research is critical to public health because it will generate novel preclinical mouse models to study tissue-specific SARS-CoV-2-induced disease and provide a deeper understanding of the fundamental mechanisms controlling lung and gut pathology.

PI_NAMEs: KOROLEVA, EKATERINA ;MARTINEZ-SOBRIDO, LUIS ;TUMANOV, ALEXEI V (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Acute Respiratory Distress Syndrome;airway epithelium;alveolar epithelium;alveolar type II cell;Animal Model;Automobile Driving;Binding;Brain;cell type;Cells;chronic inflammatory disease;Colitis;Communities;Complex;Consensus;COVID-19;COVID-19 complications;COVID-19 monitoring;COVID-19 patient;COVID-19/ARDS;cytokine release syndrome;Data;Development;Disease;effective therapy;Epithelial Cells;Generations;Goals;gut inflammation;Heart;Immune;Immune response;immunopathology;in vivo;Inflammation;innovation;insight;Intestinal Diseases;intestinal epithelium;Intestines;K-18 conjugate;Kidney;Liver;Luciferases;Lung;lung injury;Mediating;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;novel;Organ;Pathogenesis;Pathologic;Pathology;Patients;post-COVID-19;pre-clinical;Public Health;Pulmonary Pathology;receptor;Recombinants;Reporter;Reporter Genes;Research;Role;SARS-CoV-2 infection;severe COVID-19;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Tissues;tool;Transgenic Mice;Validation;Viral;Virus;Visualization

PROJECT_TITLE: Novel animal models to study organ-specific SARS-CoV-2-induced pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: JOHNSTON, JILL E (contact)

PROJECT_TERMS: Address;Air;Air Pollutants;Air Pollution;ambient air pollution;Area;base;burden of illness;California;Child;Child Health;Collaborations;Color;Communication;Communities;community advisory board;community engagement;community organizations;community partnership;community science;Creativeness;data dashboard;Democracy;design;disability;Disease;Education;Educational Curriculum;effectiveness evaluation;efficacy evaluation;Electronic Mail;empowerment;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;environmental justice;Equity;Evaluation;experience;Exposure to;Film;Fostering;Geography;hazard;health literacy;implementation science;Infrastructure;innovation;Journalism;Knowledge;knowledge base;land use;Language;Logic;Low income;Maps;Marketing;Measures;Media Campaign;Methods;Mission;Modeling;Morbidity - disease rate;mortality;Movement;multidisciplinary;Neighborhoods;news;Newsletter;novel;Pathway Analysis;people of color;Performance;Persons;Pilot Projects;Policies;Policy Maker;Pollution;Program Evaluation;programs;Public Policy;Regulation;Research;Research Personnel;Resources;response;Scholarship;Science;Scientist;Services;social disparities;social media;Source;Structure;Techniques;tool;Training;Translating;translational approach;translational goal;translational health science;translational model;Translational Research;Translations;United States;Update;Urban Community;urban planning;Work;Youth

PROJECT_TITLE: Translation Core


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Malaria, caused by Plasmodium species, is an unresolved global health burden without an effective vaccine. Development of potent and translatable vaccines against malaria has been hampered by our incomplete understanding of the mechanisms by which the immune system can be trained to control Plasmodium infections. The goal of this research is to dissect mechanisms of CD8 T cell-mediated protection against liver-stage malaria.

PI_NAMEs: HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Africa South of the Sahara;Anti-malarials;Antibodies;Antigen Presentation;Attenuated;Beds;Binding;Bite;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Clinical;combat;Culicidae;Data;Dermal;Development;Disease;Drug resistance;Epitopes;Erythrocytes;Frequencies;Generations;global health;Goals;Hepatocyte;Human;Immune system;Immunity;Immunization;Immunize;Immunology;improved;Incidence;Infection;Injections;Insecticides;Knowledge;Laboratories;Liver;Malaria;Malaria Vaccines;Mediating;Membrane;Memory;Modeling;Mus;novel;parasite invasion;Parasite resistance;Parasites;Pharmacotherapy;Plasmodium;Play;Population;prevent;Property;Radiation;recruit;Research;response;Rodent Model;Role;Route;Severities;Skin;Sporozoite vaccine;Sporozoites;T-Lymphocyte;Time;Tissues;Training;transmission process;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine development;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Immunity to Liver-stage malaria


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: LAS VEGAS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative We recently found novel CRL4 ubiquitin ligase complexes that regulate the protein levels of SRY-box2 protein, SOX2, a dose-dependent master transcriptional factor that plays a central role in regulating the self-renewal and pluripotency or multipotency of embryonic stem cells, and many fetal and adult stem cells. Haploinsufficiency of human Sox2 is sufficient to cause the familial anophthalmia/microphthalmia syndrome associated with seizures, brain abnormalities, and slow growth, whereas gene amplification and over- expression of SOX2 are frequently associated with a large spectrum of cancers. We propose to investigate this CRL4-based novel and important lysine-methylation dependent regulation on SOX2 that controls the self- renewal and pluripotency of embryonic stem cells and many fetal and adult stem cells during embryonic development and tissue homeostasis using both pluripotent stem cells and animal models.

PI_NAMEs: ZHANG, HUI  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: adult stem cell;Alleles;Animal Model;Animals;Anophthalmos;Binding;Biological Process;Bladder;Brain;brain abnormalities;brain cell;Cell Cycle;cell type;Cells;Chromatin;Cochlea;Complex;Coupled;Defect;Development;developmental disease;Disease;DNA biosynthesis;DNA Methylation;DNA Repair;DNA Sequence Alteration;Dose;E2F transcription factors;Ear;Ectoderm;Embryo;embryo cell;embryo tissue;Embryonic Development;embryonic stem cell;Endoderm;Engineering;Epigenetic Process;epigenetic regulation;Epithelium;Esophagus;Eye;fetal stem cell;Gene Amplification;Gene Expression Regulation;Genes;Genetic;GLI3 gene;Growth;HIF1A gene;histone methylation;Homeostasis;Human;Impairment;induced pluripotent stem cell;insight;KDM1A gene;Learning Disabilities;loss of function mutation;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Mesoderm;methyl group;Methylation;Microphthalmos;motor learning;Motor Skills;Mus;mutant;Mutant Strains Mice;Mutation;Nervous System Disorder;neural;non-histone protein;novel;Ovary;overexpression;Pathologic;Pathway interactions;Pattern;Phenotype;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Play;pluripotency;Pluripotent Stem Cells;prevent;protein degradation;Protein Dynamics;Protein Methylation;Proteins;Proteolysis;Proteomics;Proto-Oncogene Proteins c-akt;PTEN gene;Regulation;Research;Retina;Role;Seizures;self-renewal;Signal Transduction;Skin;stem cell function;stem cell model;stem cells;Syndrome;synergism;TAL1 gene;Testis;Threonine;Tissues;TP53 gene;transcription factor;Transcriptional Regulation;Tumor Suppressor Proteins;ubiquitin ligase;ubiquitin-protein ligase

PROJECT_TITLE: Regulation of SOX Proteins by Methylation-dependent Proteolysis in Stem Cells and Development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Topical Microbicides;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The Southeastern U.S. has the highest rates of unintended pregnancy as well as STI/HIV infection and current efforts are met with improper use of contraception and low adherence to antiretorviral pre-exposure prophylaxis (PrEP). This project is proposing to investigate behavioral and socio-cultural factors involved in contraception decisions and attitudes towards multipurpose prevention technologies by translating current knowledge from data collected in Sub-Saharan Africa to other high-risk vulnerable populations. These data will expand our understanding of women’s perceptions giving context for implementation of multipurpose prevention technologies and providing improved reproductive and sexual health options.

PI_NAMEs: TYMES-WILBEKIN, KRISTINA AYANNA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;African American population;African American Women;African Women;Alabama;Anti-Retroviral Agents;Area;Attitude;Award;Behavioral;behavioral study;Biometry;career;career development;Clinic;clinical application;Communicable Diseases;Communication;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Dapivirine;Data;Decision Making;Deep South;design;Development;Devices;Doctor of Philosophy;Epidemiology;epidemiology study;Estrogens;experience;Familiarity;Foundations;Frequencies;Future;Goals;Grant;Health Care Costs;health disparities in women;high risk;high risk population;HIV;HIV Infections;hormonal contraception;Hygiene;implementation context;implementation strategy;improved;Infectious Disease Epidemiology;interest;International;Interview;journal article;Kenya;Knowledge;Learning;Learning Skill;Linear Regressions;Literature;Measures;Menstruation;Mentors;Methodology;Methods;Modeling;Outcome;Perception;Periodicity;Pharmaceutical Preparations;pharmacologic;Physicians;Population;pre-exposure prophylaxis;Pregnancy;Pregnancy Rate;prevent;Prevention;preventive intervention;Progesterone;Publishing;Randomized, Controlled Trials;Reduce health disparities;Regimen;Reporting;Reproducibility;Reproductive Behavior;Reproductive Health;Research;research and development;Research Design;Research Proposals;response;responsible research conduct;Risk;Scientist;Sex Behavior;sexual and reproductive health;Sexual Health;Sexual Transmission;Sexually Transmitted Diseases;skills;social culture;sociocultural determinant;success;Surveys;Technology;technology development;technology validation;Testing;tool;Training;Translating;Translational Research;unintended pregnancy;United States National Institutes of Health;uptake;Vagina;Vaginal Douching;vaginal microbiome;Vaginal Ring;Vulnerable Populations;White Women;Woman;women's reproductive health;Work;Writing

PROJECT_TITLE: Perceptions of Multipurpose Prevention Technologies Aimed at HIV/STI/unintended pregnancy among African-American Women in the Deep South

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17-P(20)L]