NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The pending introduction of novel vaccines and monoclonal antibodies to prevent respiratory syncytial virus (RSV) holds promise for reducing the burden of disease in infants. We propose a large-scale epidemiologic study that integrates data from different modalities (e.g., clinical, demographic, virologic, immunologic) to evaluate the real-world effectiveness of perinatal RSV immunoprophylaxis. The results of this work will inform on the optimal implementation strategies and help build public confidence in these novel immunization programs.

PI_NAMEs: OLIVEIRA, CARLOS RAFAEL (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 1 year old;5 year old;Acute;acute care;adaptive immune response;Address;Affect;Age Months;antibody transfer;Authorization documentation;Benefits and Risks;Bioinformatics;Biological Assay;Blood;breakthrough infection;burden of illness;Case/Control Studies;Cells;Characteristics;Child;Childhood;Clinical;clinical epidemiology;clinical practice;clinical research site;Clinical Trials;Communicable Diseases;Comprehensive Health Care;Connecticut;Data;data integration;data registry;design;Development;Disease;Effectiveness;effectiveness evaluation;effectiveness measure;Enrollment;epidemiology study;Equation;European Union;Failure;Frequencies;Fright;Genetic;Genetic Variation;Health;Health Personnel;health record;Health system;Healthcare;Healthcare Systems;Hospitalization;Hospitals;Immune;Immune response;Immunization;Immunization Programs;Immunologics;immunoprophylaxis;immunoregulation;implementation strategy;Incentives;Infant;infant infection;Infant Mortality;infant outcome;Infection;Innate Immune Response;Inpatients;insight;Interview;Licensing;Licensure;Logistic Regressions;Maps;Maternal antibody;maternal vaccination;Measures;Mediating;Medical;Medical Records;Memory;Modality;Molecular;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;multiple data sources;multiple omics;Newborn Infant;novel;novel vaccines;Outpatients;Participant;participant enrollment;Passive Immunity;Passive Immunization;pathogen;Patients;Perinatal;Phase;Phase III Clinical Trials;placental transfer;Policy Maker;Population;population based;Population Characteristics;Population Heterogeneity;Pregnant Women;prevent;Prevention strategy;prophylactic;protective effect;Protocols documentation;Qualifying;Recommendation;Recording of previous events;recruit;Registries;relative effectiveness;research clinical testing;respiratory;respiratory challenge;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;response;Safety;Seasons;Severity of illness;Site;sociodemographics;Source;Surveys;Testing;Time;translational immunology;Trust;United States;uptake;vaccination strategy;vaccine development;vaccine effectiveness;vaccine efficacy;vaccine-induced antibodies;Vaccines;vaccinology;Viral;viral genomics;Virus;virus genetics;Work

PROJECT_TITLE: Real-World Effectiveness of Perinatal RSV Immunoprophylaxis

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Influenza viruses can exchange genes when they infect the same cell, creating variant viruses that can evade immunity, become more transmissible, or cause more severe disease. Predicting which strains are more likely to exchange genes has remained a challenge and the specific viral factors that influence the propensity for exchange remain understudied. This project will identify specific parts of the viral genome that restrict or promote genetic exchange to improve risk assessments, pandemic preparedness, and reveal new treatments.

PI_NAMEs: DIAZ, SAMUEL L (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;Automobile Driving;cell type;Cells;co-infection;Compensation;Complex;Complication;Coupled;Data;Dependence;Disease;Environment;Epidemiology;experimental study;Face;fitness;Frequencies;Gene Exchanges;Genetic;Genomic Segment;Genotype;Goals;Grant;Hemagglutinin;Human;Immunity;improved;Infection;infection rate;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza epidemic;influenza virus strain;influenzavirus;insight;Link;Measures;mutant;Mutation;Neuraminidase;Outcome;pandemic disease;pandemic influenza;pandemic preparedness;Pattern;Polymerase;Process;Proteins;Public Health;public health relevance;Publishing;Research;Risk Assessment;Role;seasonal influenza;segregation;Shapes;Testing;tool;Variant;Viral;Viral Genome;Virus

PROJECT_TITLE: The basis of Influenza A virus strain-dependent reassortment potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Newly emerging spatial omics experiments can promote our understanding of spatial and molecular patterns and relevant biological mechanisms associated with various organs and diseases such as cancers and neurodegenerative disorders. The proposed power analysis framework will help improving design of spatial omics experiments, which in turn will help guarantee biologically meaningful findings. The high impact of this framework will be reflected through an interactive web interface with a coding-free environment that will assist basic scientists, clinical scientists, and bioinformaticians in their design of spatial omics experiments.

PI_NAMEs: CHUNG, DONGJUN  (contact);MA, QIN

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;age related;Aging;aging related;Architecture;Award;Benchmarking;bioinformatics tool;Biological;biomedical informatics;Cell Communication;cell type;Cells;Characteristics;Clinical;Code;Computer software;computerized tools;Data;Data Analyses;data modeling;Data Set;design;Development;Dimensions;Disease;Ecosystem;Environment;Experimental Designs;experimental study;Foundations;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;Human;Image;Immunooncology;improved;Informatics;informatics shared resource;Knowledge;Literature;Location;longitudinal design;Lung;Malignant Neoplasms;Measurement;Measures;Methods;Modeling;Molecular;National Human Genome Research Institute;Neurodegenerative Disorders;new technology;Normal Statistical Distribution;novel therapeutic intervention;Ohio;open source;Organ;Outcome;Pathogenicity;Pattern;Population;power analysis;Process;protein expression;Proteomics;Provider;Public Domains;Pulmonary Fibrosis;Research;Research Personnel;Sample Size;Sampling;Science;Scientist;simulation;single-cell RNA sequencing;Software Design;Spatial Design;Specific qualifier value;Statistical Models;statistics;Technology;technology development;Tissues;tool;tool development;transcriptomics;Universities;user friendly software;user-friendly;Variant;web interface;web portal

PROJECT_TITLE: Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics Experiments

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Prevention;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This research aims to understand how optimized ankle and hip exoskeletons in combination with biofeedback can impact walking speed, gait energetics, gait biomechanics and clinically meaningful outcomes in stroke survivors. Through the use of novel deep learning systems and optimization systems, exoskeleton assistance can be personalized to a patient’s unique walking pattern, which can then be further improved through use of targeted biofeedback. These results have the potential to enhance quality of life for individuals post-stroke by improving independent community ambulation through improvements in mobility, independence and overall quality of life.

PI_NAMEs: KESAR, TRISHA ;SAWICKI, GREGORY STEPHEN;YOUNG, AARON JOHN (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acceleration;Address;Adoption;Ankle;ankle joint;Area;Artificial Intelligence;authority;Awareness;Bilateral;Biofeedback;biomechanical test;Biomechanics;Characteristics;Clinical;clinical application;clinical translation;clinically relevant;cohort;Communities;community setting;Compensation;cost;Coupled;Cues;Data;deep learning;Devices;disability;Distal;Environment;exoskeleton;exoskeleton device;experience;Gait;Hip Joint;Hip region structure;Human;improved;improved mobility;Individual;innovation;Joints;Knowledge;Laboratories;Learning;Leg;leg paresis;light weight;Limb structure;Link;Lower Extremity;Machine Learning;Measurement;Measures;Mechanics;Metabolic;motor control;motor learning;Muscle;Muscle Weakness;Neuromechanics;new technology;novel;Outcome;Patient Outcomes Assessments;Patients;Pattern;Perception;Performance;Personal Satisfaction;personalized approach;Persons;Phase;Positioning Attribute;post stroke;Quality of life;Research;research clinical testing;restoration;robot assistance;robot exoskeleton;Robotics;Secondary to;Self-Help Devices;Seminal;Stroke;stroke survivor;System;technological innovation;Technology;Testing;Time;Walking;walking speed;wasting;wearable device;Work

PROJECT_TITLE: Personalized Hip vs Ankle Exoskeleton Assistance with Biofeedback to Enhance Mobility Post-Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SMEP-C (05)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Microbiome;Pain Research;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Overactive bladder (OAB) is an extremely common symptom complex that is challenging to treat clinically due to several underlying etiologies. This proposal seeks to elucidate OAB subtypes utilizing comprehensive clinical and demographic data from two NIDDK-funded consortia networks and to further identify if the addition of microbiome characteristics aids in defining OAB subtypes. We additionally will determine if stratification by OAB subtype improves predicted response to OAB treatment.

PI_NAMEs: KARSTENS, LISA ANNE;SIDDIQUI, NAZEMA Y (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Affect;Algorithms;Anatomy;Benign;Biological;Characteristics;Classification;Clinical;Clinical Data;Clinical Management;clinical phenotype;cohort;common symptom;Complex;Confidence Intervals;Data;Data Scientist;Data Set;Disease;dysbiosis;Effectiveness;Etiology;experience;Female;Frequencies;Functional disorder;Funding;Goals;Health Care Costs;improved;Incontinence;Infection;innovation;interdisciplinary approach;Knowledge;Lower urinary tract;lower urinary tract symptoms;male;Mathematics;Measures;Medical;Metabolic;Methods;microbial;microbiome;micturition urgency;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Neurologic;Nocturia;observational cohort study;Overactive Bladder;Pain;Painless;Participant;Pathology;Patients;Pelvic floor dysfunction;Pelvic Pain;Phenotype;predicting response;Prediction of Response to Therapy;predictive modeling;Probability;Process;prospective;Research;Resources;sex;Specimen;Stratification;Subgroup;Symptoms;Syndrome;Testing;Treatment outcome;treatment response;Urinary tract infection;urologic;Urology;Visit;Work

PROJECT_TITLE: Predicting phenotypes in benign urology

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Children with advanced neuroblastoma continue to have poor outcomes despite intensive, multimodal therapy. One of the most effective therapies utilized when patients have relapsed or refractory disease is 131I-MIBG radiotherapy. Through an existing clinical trial testing novel targeted agents in combination with 131I-MIBG (NANT 2021-02), we will investigate whether liquid biopsies can identify biomarkers to help predict why some patients respond or become resistant to combination radiopharmaceutical approaches which will lead to optimized treatment selection and new candidate therapies in patients with neuroblastoma.

PI_NAMEs: CROMPTON, BRIAN ;VO, KIEUHOA TRAN (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Antigens;arm;Award;Biological;Biological Markers;biomarker identification;Biopsy Specimen;Blood;Blood specimen;blood treatment;Cell Line;Cells;Child;Childhood;Chromatin;circulating biomarkers;Clinical;Clinical Trials;Combined Modality Therapy;deep sequencing;Detection;Development;Disease Progression;Disease Resistance;Down-Regulation;effective therapy;Epigenetic Process;Evolution;experience;Gene Expression;Gene Expression Profile;Histone Deacetylase Inhibitor;Human;Immunotherapy;liquid biopsy;longitudinal analysis;Measures;metaiodobenzylguanidine;minimally invasive;Modeling;Monoclonal Antibodies;Mutation;Neoplasm Circulating Cells;Neuroblastoma;neuroblastoma cell;noradrenaline transporter;novel;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Outcome;participant enrollment;Patients;Pattern;peripheral blood;phase 2 study;phase II trial;Plasma;Ploidies;Population;Pre-Clinical Model;preclinical study;predicting response;predictive marker;prevent;programs;Progressive Disease;prospective;Radiation;Radiation therapy;Radiopharmaceuticals;Randomized;Recurrence;Recurrent disease;Refractory;Refractory Disease;Relapse;Resistance;resistance mechanism;response;response biomarker;Sampling;Selection for Treatments;Somatic Mutation;Surface;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapy development;therapy resistant;treatment arm;treatment optimization;treatment response;trial design;tumor;tumor DNA;Vorinostat;Work;Xenograft Model

PROJECT_TITLE: Circulating biomarkers of clinical response to combination targeted therapies in neuroblastoma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Sleep Apnea is a common chronic disorder affecting over 1 billion patients worldwide. Current method of diagnosing OSA using the apnea hypopnea index has demonstrable limitations and to overcome those limitations our proposal utilizes state-of-the-art artificial intelligence/machine-learning model that provides risk of short- and long-term outcomes using data from routine sleep studies. The present proposal will assess the real- world performance of our artificial intelligence/machine-learning that has the ability to enhance clinical management of sleep apnea

PI_NAMEs: PAREKH, ANKIT ASHOK (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Academy;adverse outcome;Advisory Committees;Affect;Age;Agreement;American;Apnea;Area;Arousal;Artificial Intelligence;Big Data;Big Data Methods;Cardiovascular Diseases;Cardiovascular system;cerebrovascular;Chronic;Chronic Disease;Classification;Clinic;Clinical;Clinical Management;clinical practice;cohort;Continuous Positive Airway Pressure;Coupled;Data;Data Engineering;Data Set;Decision Making;Diagnosis;Drowsiness;Epidemiology;Equation;Etiology;Evaluation;Event;Excessive Daytime Sleepiness;Exhibits;explainable artificial intelligence;Female;Frequencies;Functional disorder;Health system;Heterogeneity;Hypertension;Hypoxia;improved;indexing;International;Learning;learning outcome;Machine Learning;machine learning model;Measures;Medicine;Methods;Modality;Modeling;Morbidity - disease rate;mortality;Neurocognitive Deficit;New York;Obstructive Sleep Apnea;Oral;Outcome;Oxygen;patient subsets;Patients;Performance;Persons;Physiology;Polysomnography;Population;Probability;Prognosis;prospective;random forest;recruit;Reporting;Research;respiratory;response;Retrospective cohort;Risk;risk prediction;risk stratification;Science;Severities;Sleep;Sleep Apnea Syndromes;Societies;Subgroup;Symptoms;Testing;tool;Training;Translating;treatment effect;Uncertainty;Validation;Weight

PROJECT_TITLE: Physiology guided AI for going beyond the AHI in Sleep Apnea

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Friedreich’s ataxia (FRDA), a neurodegenerative disease, is caused by a trinucleotide repeat expansion within the frataxin gene, which is a protein located within mitochondria. We showed in the mouse model of FRDA that bone marrow hematopoietic stem cells (HSCs) that give rise to blood cells, holds great promise to treat FRDA, by differentiation of the transplanted HSCs into microglia/macrophages (type of immune cells) within tissues, that will transfer the functional frataxin to the brain cells (neurons). The contribution of innate immune cells to FRDA and the exact mechanism of frataxin transfer is still unknown, we will utilize induced pluripotent stem cells (iPSCs) derived from FRDA patients and healthy donor fibroblasts to generate microglia, neurons, and cerebral organoids (mini-brains) to probe the therapeutic potential of repeat correction in immune cells, and transfer of frataxin and potentially mitochondria to affected neurons.

PI_NAMEs: CHERQUI, STEPHANIE  (contact);COUFAL, NICOLE GABRIELE

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 15 year old;3-Dimensional;Address;Affect;Allogenic;Ataxia;Autologous;autosome;Binding;Biological Models;Blood Cells;Bone Marrow;Brain;brain cell;Cardiac;Cardiomyopathies;Cell Therapy;cell type;Cells;Cellular Stress;Cerebellum;Cerebrum;clinical application;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Communities;Complex;CRISPR/Cas technology;curative treatments;Data;Disease;disease model;Exhibits;exosome;expectation;Fibroblasts;frataxin;Friedreich Ataxia;gene correction;Genes;Genetic Materials;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Human;human model;humanized mouse;Immune;Impaired cognition;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;Infusion procedures;insight;Introns;Investigational Drugs;iron metabolism;Macrophage;Mediating;Methods;Microglia;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;molecular phenotype;mouse model;Mus;Muscle;Muscle Weakness;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurons;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathogenesis;Pathologic;Pathology;Patients;Phenotype;prevent;protein expression;Proteins;Resources;response;Risk;Role;Route;Sensory;Stem cell transplant;success;Symptoms;System;Testing;Therapeutic;Time;Tissues;transcriptomics;Translating;translational approach;Transplantation;Trinucleotide Repeat Expansion;Wheelchairs;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Microgial contribution and therapeutic potential in Friedreich's ataxia

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with extensive collagen (Col) accumulation. Col remodeling and differential activation of the Col receptor DDR1 by cleaved (c) and intact (i) Col I or III control PDAC metabolism and malignancy. We will investigate how Col I/III cleavage by matrix metalloproteinases (MMPs) enables DDR1 activation, how iCol I triggers DDR1 degradation and identify MMPs responsible for Col I/III cleavage, thereby providing new targets for PDAC treatment.

PI_NAMEs: BRENNER, DAVID A.;KARIN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Ablation;Autophagocytosis;Binding;Biochemical;Biogenesis;Biological;Biology;Bypass;cancer cell;Cell model;Clinical;COL1A1 gene;Collagen;Collagen Fiber;Collagen Receptors;Collagen Type I;Compensation;Complex;Cultured Cells;DDR1 gene;Deposition;Desmoplastic;Development;Down-Regulation;Evaluation;Excision;experimental study;Extracellular Matrix;Fiber;Fibrillar Collagen;Fibroblasts;Fibrosis;Fucus;Future;Gene Modified;Goals;Growth;Hepatic;Human;improved;In Vitro;Individual;Inflammation;innovation;intrahepatic;Isoenzymes;Ligase;Liver;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Matrix Metalloproteinases;Mediating;Metabolic stress;Metabolism;Metalloproteases;Microbial Collagenase;Mitochondria;mouse model;Mouse Strains;multicatalytic endopeptidase complex;Mus;Mutant Strains Mice;Mutation;Myeloid Cells;Myofibroblast;Neoplasm Metastasis;NF-kappa B;Nude Mice;Nutrient availability;Nutritional;Pancreas;Pancreas Transplantation;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patients;pharmacologic;Play;Pre-Clinical Model;Prevention;Process;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Resistance;Respiration;Role;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;small molecule;Specimen;Stress;System;targeted treatment;Technology;Testing;therapeutic target;Time;tool;trait;tumor;tumor metabolism;tumor vascular supply;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Collagen fibers and fragments regulate pancreatic cancer metabolism and growth.

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Pain Research;Physical Activity;Prevention;Telehealth

ORG_CITY: STANFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Despite growing evidence of the complex, interconnected pathways linking the mind and body, scalable interventions that efficiently target whole-person health upon diagnosis of a life-altering disease such as cancer have not yet been developed. We plan to address this gap and build on our extensive foundational research, completed over the past 6 years with support of the NIH New Innovator Award (DP2 AT009511), to test a novel mHealth intervention, MINDSET, which targets the mindsets of people with cancer at the point of diagnosis. By promoting health at the psychological, behavioral, and biological levels, MINDSET interventions have the potential to become a highly impactful and complementary tool for more patient-centered cancer treatments.

PI_NAMEs: CRUM, ALIA  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Address;Affect;Affective;Anxiety;anxiety symptoms;associated symptom;attentional control;Award;Behavior;Behavioral;Biological;Biology;Biometry;cancer diagnosis;Cancer Patient;cancer therapy;chemotherapy;Chronic;chronic pain;Clinical;clinical care;Cognitive;Cognitive Therapy;Complex;coping;cost;cost efficient;Decentralization;depressive symptoms;Development;Diabetes Mellitus;Diagnosis;Diffuse;digital;digital delivery;Disease;Dissemination and Implementation;Distress;Emotional;emotional functioning;experience;Fatigue;Film;follow-up;functional restoration;Goals;Health;Health Promotion;Hematologic Neoplasms;Hour;improved;indexing;Individual;Inflammatory;Intervention;intervention effect;Life;Link;Local Therapy;Malignant Neoplasms;Measures;Mediating;Medical;Mental Depression;Mental Health;Methods;mHealth;mhealth interventions;Mind-Body Intervention;mind/body;mindfulness-based stress reduction;National Center for Complementary and Integrative Health;Nature;Nonmetastatic;novel;Oncology;osteoarthritis pain;Outcome;Pain;Participant;Pathway interactions;patient oriented;Patients;Persons;Phase;Physical activity;Physical Function;physical symptom;Physiological;Physiology;primary outcome;programs;Psychiatry;psychologic;psychological symptom;Psychology;Quality of life;Randomized, Controlled Trials;Reporting;Research;routine care;secondary outcome;Sleep;sleep difficulty;social;Social Functioning;Solid Neoplasm;Supportive care;Symptoms;Systemic Therapy;Testing;Time;tool;treatment as usual;United States National Institutes of Health;whole health

PROJECT_TITLE: Changing Mindsets to Improve Whole Patient Health: A Randomized Controlled Trial of a Novel mHealth Intervention for People Diagnosed with Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (05)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: Project Narrative Chronic inflammation contributing to the development of cardiovascular disease is difficult to treat because innate immune cells become primed to a hyperinflammatory response. This research project will address formation of inflammarafts, reprogrammed plasma membrane microdomains hosting complexes of inflammatory receptors, and mitochondrial dysfunction in atherosclerotic lesion macrophages. Strategies to target inflammarafts and mitochondrial dysfunction will advance the development of novel therapeutics to treat atherosclerosis and cardiovascular disease.

PI_NAMEs: MILLER, YURY  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Advanced Development;Apolipoprotein A-I;Architecture;Arterial Fatty Streak;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;Binding;Binding Proteins;Bioenergetics;Biological Assay;Blood Vessels;Cardiomyopathies;Cardiovascular Diseases;Cell membrane;Cell surface;Cells;Characteristics;Cholesterol;Cholesterol Homeostasis;cholesterol transporters;Chronic;Clinical;Complex;Coronary Arteriosclerosis;Coronary artery;Data;Development;Electron Microscopy;Esterification;extracellular;Face;Flow Cytometry;Foam Cells;gain of function;Gene Expression;Genes;Genetic;Genus Hippocampus;Goals;Heart;Heart failure;Heart Transplantation;Human;hypercholesterolemia;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Lipid-Laden Macrophage;Lipids;Liver;loss of function;Macrophage;Maintenance;Measures;Mediating;Membrane Microdomains;Methods;Microscopic;Mitochondria;mitochondrial dysfunction;mitochondrial oxidative dysfunction;Morphology;Mus;novel therapeutics;Oxidative Stress;Patients;Physiological;Population;Protein Deficiency;Proteins;receptor;recruit;Research Project Grants;Respiration;Risk Factors;scaffold;Scanning Electron Microscopy;Shapes;Signal Transduction;single cell analysis;Testing;Therapeutic;TLR4 gene;tomography;tool;Transplantation Surgery;Variant;vascular inflammation

PROJECT_TITLE: Macrophage Inflammarafts and Mitochondrial Dysfunction in Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations, some of which are toxic. Because these proteins have identical amino acid sequences, the cellular environment clearly influences the final state, yet most structural studies do not include the cellular context and, perhaps because we are not studying the correct conformation, not a single therapeutic strategy for these diseases addresses the underlying protein misfolding pathology. Using new sensitivity-enhancement technology for solid state NMR spectroscopy, we will study protein structure in native environments - inside living cells - to reveal how cellular environments influence protein structure.

PI_NAMEs: FREDERICK, KENDRA KING (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acceleration;Address;Adopted;Alzheimer's Disease;Amino Acid Sequence;Amyloid;Amyloid fibers;Amyloid Fibrils;amyloid formation;amyloid structure;Biological;Biological Models;biological systems;Biosensor;Cell Line;Cells;conformer;Crowding;Cryoelectron Microscopy;cryogenics;Data;Detection;Development;Diagnostic;Disease;Enhancement Technology;Environment;experimental study;Exposure to;Fiber;Freezing;Frequencies;Genetic Polymorphism;In Vitro;in vitro activity;Individual;interest;Investigation;Knowledge;Ligands;Mammalian Cell;Masks;Methodology;Methods;Minority;misfolded protein;Molecular Conformation;Molecular Structure;Monitor;Morphology;Neurodegenerative Disorders;NMR Spectroscopy;Nuclear;Organism;Parkinson Disease;Pathology;Pathway interactions;Patients;Phase;polymerization;Polymers;Polymorph;Population;Positron-Emission Tomography;preference;Preparation;Prevalence;protein aggregation;protein folding;protein misfolding;protein structure;Proteins;Reaction;reconstruction;Renaissance;Reporting;response;restraint;Sampling;Shapes;Site;solid state nuclear magnetic resonance;Source;structural biology;Structure;System;Techniques;Temperature;Therapeutic;therapeutic development;Time;tool development;Toxic effect;transmission process;treatment response;Work

PROJECT_TITLE: High sensitivity NMR for structure determination of neurodegenerative disease associated protein aggregates in native contexts

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE While immune checkpoint blockade is an effective cancer treatment, many individuals do not respond. Patients with a mutation in the ARID1A gene respond better to immune checkpoint blockade, indicating that ARID1A may be a biomarker for immune checkpoint blockade therapy. ARID1A mutation results in DNA replication stress in the form of R loops, which may drive heightened anti-tumor immunity and immune checkpoint blockade responsiveness through activation of an inflammatory response.

PI_NAMEs: HARGREAVES, DIANA CLARE (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Affect;anti-tumor immune response;Antigen Presentation;Antigen Presentation Pathway;ARID1A gene;ATP Hydrolysis;Automobile Driving;Back;Biological Process;Biology;cancer biomarkers;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;CDKN2A gene;cell killing;Cells;chemokine;Chromatin;Chromatin Remodeling Factor;Clinical;Clinical Trials;combat;CRISPR/Cas technology;Cytoplasm;Cytosol;Cytotoxic T-Lymphocytes;Defect;DNA;DNA biosynthesis;effective therapy;endonuclease;Endosomes;Enzymes;Excision;Exhibits;Failure;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Markers;genetic signature;Goals;Homeostasis;Human;Hybrids;IFNAR1 gene;immune cell infiltrate;immune checkpoint blockade;Immune system;Immunologic Markers;Immunoprecipitation;Immunotherapy;improved;in vivo;Individual;Inflammatory;Inflammatory Response;inhibitor;Interferon Type I;Interferons;knock-down;Ligands;Lymphocytic Infiltrate;Malignant Neoplasms;Measures;Mediating;Microsatellite Repeats;Modeling;Molecular;molecular marker;Molecular Profiling;mouse model;Mus;mutant;Mutate;Mutation;neoplastic cell;Nuclear;Nucleic Acids;Nucleosomes;Outcome;overexpression;Pathway interactions;patient response;Patient Selection;Patients;Pattern recognition receptor;pharmacologic;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;prevent;programs;receptor;replication stress;response;Retrospective Studies;RNA;Role;Signal Transduction;Single-Stranded DNA;small molecule inhibitor;Solid Neoplasm;SWI/SNF Family Complex;T-Cell Activation;T-Lymphocyte;Testing;TLR3 gene;TP53 gene;transcriptomics;translational impact;treatment response;TREX1 gene;tumor;tumor growth;Tumor Immunity;Tumor Suppressor Proteins;tumor-immune system interactions;Work

PROJECT_TITLE: The Role of the Tumor Suppressor ARID1A in R loop Homeostasis and Tumor Immunity

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: WILLISTON

ORG_NAME: MICROBRIGHTFIELD, LLC

ORG_STATE: VT

PHR: Narrative This project develops a revolutionary new microscope based on a technological breakthrough called Scanned Line Angular Projection two photon laser scanning microscopy. This microscope will enable optical imaging of neuronal activity at subcellular spatial resolution with a temporal resolution in the millisecond range both in vivo and in vitro using a variety of fluorescent indicators (e.g. voltage and neurotransmitter). As a result, new avenues of neuroscience research will become possible providing promise for the elucidation of novel biological mechanisms associated with human brain disease, and ultimately the basis for developing novel therapies to prevent and treat complex brain diseases.

PI_NAMEs: GLASER, JACOB R (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Address;Behavioral;Biological;Biosensor;Biotechnology;Brain;Brain Diseases;Calcium;Cells;Central Nervous System;Central Nervous System Diseases;Cerebral cortex;Collaborations;Communities;Complex;Computer software;Cortical Column;design;Development;Devices;digital;Electrodes;Feasibility Studies;Fiber;Functional Magnetic Resonance Imaging;Generations;Human;Image;imaging capabilities;improved;In Vitro;in vivo;Individual;innovation;interest;invention;Knowledge;Laser Scanning Microscopy;Lasers;Letters;Light;Medical;Microscope;millisecond;Morphologic artifacts;Motion;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuromodulator;Neurons;neuropsychiatric disorder;Neurosciences Research;Neurotransmitters;new technology;next generation;novel;novel therapeutics;optical imaging;Optics;Pattern;Phase;Photometry;Population;prevent;Process;Production;prototype;Research;research and development;Resolution;Rotation;Scanning;Signal Transduction;Slice;Societies;Specimen;Stimulus;Surface;System;Technology;temporal measurement;Testing;tomography;treatment strategy;two-photon;usability;Validation;voltage;Wisconsin;Work

PROJECT_TITLE: Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARATIVE The proposed research is relevant to public health because it will advance our understanding of how the human thalamus contributes to goal-directed behaviors (cognitive control). Many psychiatric and neurological disorders, such as schizophrenia, attention-deficit hyperactivity disorder (ADHD), stroke and traumatic brain injury, affect thalamic function and have significant impairments in cognitive control. The proposed research is relevant to NIH's mission because it can provide insights into the diagnosis and treatment of clinical disorders inflicted by dysfunctional cognitive control.

PI_NAMEs: HWANG, KAI  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Anatomy;Animal Model;Anterior;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Cell Nucleus;Clinical Treatment;Cognitive;cognitive control;cognitive function;cognitive rigidity;cognitive system;cognitive task;comparison control;comparison group;Corpus striatum structure;Data;Diagnosis;Disease;distraction;Electroencephalography;Exhibits;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;Human;Image;Impairment;Individual;innovation;insight;Lesion;Maintenance;Maps;member;Mental disorders;Mission;Morphology;Motor;multimodal neuroimaging;Nervous System Disorder;neural;Neurocognitive;Neurons;Neuropsychology;Neurosciences;novel strategies;Pathway Analysis;Patients;Pattern;Play;Process;Property;Public Health;Publishing;Pulvinar structure;Records;recruit;Research;Resolution;response;Role;Schizophrenia;Short-Term Memory;Specific qualifier value;Stroke;Structure;System;Task Performances;Testing;Thalamic Nuclei;Thalamic structure;translational neuroscience;Traumatic Brain Injury;United States National Institutes of Health

PROJECT_TITLE: Cognitive Control Functions of the Human Thalamus

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Microbiome

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative: Skin and soft tissue infections are a major public health threat. The skin creates a physical and immunological barrier against invasive infection, however, we have an incomplete understanding of host defense mechanisms in the skin. In this proposal we show that sebaceous glands express small proline-rich proteins (SPRR) and investigate the impact of these proteins on cutaneous host defense.

PI_NAMEs: HARRIS-TRYON, TAMIA ALISHA (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 16S ribosomal RNA sequencing;Animals;Antibiotic Resistance;antimicrobial;Award;Bacteria;Binding;Biochemical;Biochemistry;burden of illness;career;Cell Death;Cell Nucleus;Cell Wall;Cells;Cellulitis;Cutaneous;Data;Defense Mechanisms;Dermatology;Development;Doctor of Medicine;Doctor of Philosophy;Endoplasmic Reticulum;Enterococcus faecalis;Environment;Epithelium;experimental study;Family;fighting;Fluorescent in Situ Hybridization;fungus;Gastrointestinal tract structure;Gene Family;Gene Proteins;Genes;Genetic Engineering;Genomics;Gland;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Home;Host Defense;Host Defense Mechanism;Human;Immune;Immune system;Immunity;Immunologics;In Vitro;in vivo;Infection;infectious disease treatment;Infectious Skin Diseases;Inflammatory;insight;International;Intestines;Invaded;keratinocyte;Lipopolysaccharides;member;Membrane;Mentorship;methicillin resistant Staphylococcus aureus;Microbe;microbial host;microbiome;microbiota;microorganism;Modeling;mouse model;Mus;Names;novel therapeutics;Oils;pathogen;pathogenic bacteria;Pathway interactions;Persons;Physiological;Play;Postdoctoral Fellow;Predisposition;programs;Proline;proline-rich proteins;protein expression;Protein Secretion;Proteins;Public Health;recruit;Research;Research Proposals;resistant strain;resistin;response;Role;Scientist;Sebaceous Glands;Shapes;skills;Skin;skin barrier;skin disorder;skin microbiome;Soft Tissue Infections;SPRR1A;SPRR1B;Staphylococcus aureus;Staphylococcus epidermidis;Streptococcus;Streptococcus pyogenes;Surface;Techniques;Testing;trafficking;Training;transcriptome sequencing;Virus;Visualization;Work;Wound Infection

PROJECT_TITLE: The Function of Small Proline Rich Proteins in Cutaneous Host Defense

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Gene Therapy;Genetics;Lung;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE ARDS (acute respiratory distress syndrome) is an acute inflammation of the lung’s air sacs (alveoli), which normally causes 75,000 annual US deaths; though that number has been multiplied dramatically by COVID-19, which kills via ARDS. While developing nanotechnology-based drug carriers for ARDS, we discovered that one of the most ancient immune components, the complement pathway, interacts with nanocarriers in ways that are both therapeutic and produce side effects. Here we will develop nanotechnologies that will augment complement’s therapeutic effects and prevent its side effects, with implications for other acute inflammatory conditions, such as sepsis, stroke, and heart attack.

PI_NAMEs: BRENNER, JACOB  (contact);MUZYKANTOV, VLADIMIR R;SONG, WENCHAO

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Adopted;Affect;Air Sacs;Alveolar;Alveolus;Amino Acid Motifs;Anaphylaxis;Antibodies;antibody conjugate;Artificial nanoparticles;Binding;Binding Proteins;Biological Assay;Blood;Blood capillaries;Blood Proteins;C3bi;Cause of Death;Cells;Cessation of life;clinical translation;Complement;complement 3 regulator;Complement 3a;Complement Activation;Complement Factor H;complement pathway;COVID-19;COVID-19 mortality;Critical Care;Critical Illness;cytokine;density;design;Disease;Drug Carriers;Drug Delivery Systems;Endothelial Cells;Endothelium;Engineering;ex vivo perfusion;experimental study;Functional disorder;Genetic Complementation Test;Human;human tissue;Hypotension;Immune;improved;In Vitro;in vitro testing;in vivo;Inflammatory;inhibitor;Injections;Knock-out;Lead;Leukocytes;Life;Ligands;Liposomes;Lung;lung injury;Macrophage-1 Antigen;Malignant Neoplasms;Measures;Membrane Proteins;Microbe;migration;Modeling;Monoclonal Antibodies;mouse model;Mus;Myocardial Infarction;nanocarrier;nanomedicine;nanoparticle;Nanotechnology;Nebulizer;neutralizing antibody;neutrophil;Oleic Acids;Organ;Outcome;Outpatients;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Plasma Proteins;Play;prevent;Properdin;Pulmonary Inflammation;Reaction;receptor;Recombinants;Reporting;Role;Sepsis;Serum;Side;side effect;Spleen;standard measure;Stroke;Technology;Testing;Therapeutic;Therapeutic Effect;tissue resource;translational potential;uptake;Wild Type Mouse;Work

PROJECT_TITLE: Controlling complement to unleash nanomedicine for acute critical illnesses

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Only around 30% of human pregnancies progress to live birth with a great majority failing due to developmental defects, often resulting from aneuploidy. We will use a mouse model to assess how aneuploid cells can be eliminated or side-lined in development that will establish the circumstances in which pregnancies can be successfully established from aneuploid mosaic embryos. Our work will thus inform IVF strategies in the clinic enabling a more accurate assessment of the developmental potential of mosaic aneuploid embryos and permitting the development of better methods to assess the probability of successful pregnancy.

PI_NAMEs: ZERNICKA-GOETZ, MAGDALENA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Abnormal Cell;Aneuploid Cells;Aneuploidy;Apoptosis;Autophagocytosis;Biological;biological adaptation to stress;Biological Models;blastocyst;Cell Cycle;Cells;Chromosomes;Clinic;Compensation;Conceptus;Congenital Abnormality;coping;Defect;Development;Diagnosis;Diploid Cells;Disease;early pregnancy loss;Embryo;embryo cell;embryo culture;Embryonic Development;Ensure;Epigenetic Process;Failure;Fertility;Fertilization in Vitro;Fetus;fetus cell;fitness;Foundations;FRAP1 gene;Gene Expression;Genetic;Germ Cells;Germ Layers;Germ Lines;Growth;Human;Implant;implantation;improved outcome;Infertility;Inner Cell Mass;insight;Knowledge;Light;Live Birth;Metabolism;Methods;Modeling;Morphogenesis;Morphology;mosaic;Mosaicism;Mothers;mouse model;Mus;National Institute of Child Health and Human Development;natural Blastocyst Implantation;novel;Organism;Pathway interactions;pharmacologic;Placenta;pluripotency;Pregnancy;Pregnancy loss;Pregnancy Outcome;prevent;Probability;Process;Proliferating;Proteomics;proteostasis;proteotoxicity;Reproductive Biology;reproductive success;response;Role;Shapes;spatiotemporal;Spontaneous abortion;Technology;three-dimensional modeling;Tissues;TP53 gene;transcriptome;Translations;Woman;Work

PROJECT_TITLE: Biological mechanisms that eliminate aneuploid cells from a mosaic conceptus in the mouse model system

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Inhibitory neurons of the dorsolateral hypothalamus regulate sleep, but little is known about how these neurons are generated and maintained. We have identified a new class of hypothalamic neurons that require the transcription factor Lhx6 for their development and survival. We propose to identify the molecular mechanisms by which Lhx6 controls the development of these neurons, and determine their precise role in control of sleep.

PI_NAMEs: BLACKSHAW, SETH  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Anterior;ATAC-seq;cell motility;Defect;Development;Elements;experimental study;Gene Expression Profiling;Genes;genetic analysis;genetic approach;Genetic study;homeodomain;Homeostasis;Hypothalamic structure;inhibitory neuron;insight;Interneurons;Maintenance;Mediating;migration;Molecular;molecular subtypes;mutant;neural circuit;neuron development;Neurons;new therapeutic target;Pathway interactions;Play;Population;Posterior Hypothalamus;pressure;Process;Regulatory Element;Role;selective expression;Signal Transduction;Sleep;Sleep Disorders;sleep regulation;Sleep Wake Cycle;Specific qualifier value;Testing;therapeutic target;transcription factor;transcription regulatory network;Work;zona incerta

PROJECT_TITLE: Development and function of hypothalamic Lhx6-positive neurons

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE G protein-coupled receptors are responsible for regulating nearly every physiological process in the human body, which makes them an important target for drug development. The purpose of this project is to detail the effects of dynamic post-translational modification s-palmitoylation on the conformational plasticity and subsequent intracellular signaling of the β2 adrenergic receptor, utilizing a combination of electron paramagnetic resonance techniques along with pharmacological and cellular signaling assays. The results from this project will generate a more adept understanding of β2 adrenergic receptor signaling and regulation within the context of a physiologically relevant cellular environment, thus allowing for the design of more effective treatments targeting cardiac β2 adrenergic receptor signaling.

PI_NAMEs: BRENNAN, PATRICK C (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acylation;Address;Adrenergic Agents;Adrenergic Receptor;Affinity;Agonist;beta-2 Adrenergic Receptors;beta-arrestin;Biological Assay;C-terminal;Cardiac;Cardiac Output;Cardiovascular Diseases;Cell membrane;Cell Surface Receptors;Cells;Clinical;Country;Coupling;Cysteine;Cytoplasm;Cytoplasmic Receptors;design;Dimensions;Drug Design;drug development;Drug Targeting;effective therapy;Electron Spin Resonance Spectroscopy;Electrons;Environment;Equilibrium;Event;experience;experimental study;extracellular;Family;Fellowship;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Heart failure;Heterogeneity;Human;Human body;improved;insight;Investigation;Kinetics;Ligands;Link;Lipid Bilayers;Lipids;Maps;Measures;Mediating;member;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;mutant;novel;Outcome;Palmitates;Palmitic Acylation Site;palmitoylation;Pathway interactions;Performance;pharmacologic;Pharmacology;Phosphorylation;Phosphorylation Site;Physiologic pulse;Physiological;Physiological Processes;Physiology;Post-Translational Protein Processing;Process;protein activation;Protein Dynamics;protein function;protein structure;Proteins;receptor;Receptor Signaling;recruit;Regulation;Research Personnel;Role;Side;Signal Pathway;Signal Transduction;Site;Solvents;Spin Labels;Structure;Surface;Tail;Techniques;Transducers;Transferase

PROJECT_TITLE: Structural basis for regulation of beta2 adrenergic receptor signaling by the dynamic post-translational modification S-palmitoylation


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This proposal aims to define how NMNAT1 as an NAD+ synthetase provides NAD+ to fuel chromatin remodeling enzyme activities to regulate chromatin structure and gene expression dynamics. Impairments in regulating these processes lead to a significant number of human pathologies, including cancer and age- related diseases. Therefore, understanding the functions of NMNAT1 as a nuclear metabolic enzyme in regulating chromatin remodeling and gene expression is crucial to define new paradigms regarding gene expression and regulation.

PI_NAMEs: CEDENO, YESSENIA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;age-related disease;ATAC-seq;Binding;career;CDKN1A gene;Cell Cycle Arrest;Cell Line;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromatin Fiber;chromatin remodeling;Chromatin Structure;Color;CRISPR/Cas technology;Data;Defect;enzyme activity;Enzymes;experimental study;Functional disorder;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;Genomic approach;genomic locus;Genomics;human disease;Human Pathology;imaging approach;imaging system;Impairment;insight;Kinetics;Knock-out;Knowledge;Lead;Ligase;Malignant Neoplasms;Mediating;Mentorship;Metabolic;Metabolism;Microscopy;Modeling;Molecular;Molecular and Cellular Biology;Morphology;multidisciplinary;mutant;Mutation;Nicotinamide-Nucleotide Adenylyltransferase;novel;Nuclear;particle;Phenotype;Power Plants;Process;Production;Publishing;Regulation;Research;Role;Scientist;Series;single molecule;SIRT1 gene;Structure;System;Training;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Role of Nicotinamide Nucleotide Adenylyltransferase-1 (NMNAT1) in Chromatin Remodeling and Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: Project Narrative The proposed ITN UM1 funding addresses major unmet health needs. In the United States, autoimmune diseases affect >5% of the population, and allergic diseases affect another ~15%. Transplantation is a life- saving intervention for organ failure, but risky and burdensome. In each area, pre-clinical studies show that immune tolerance should be an achievable therapeutic prospect, and progress towards that goal is evident in recent clinical trials. Successful tolerance offers long-term freedom from immunosuppressive therapy, radically improving quality of life, disease burden, and health care costs. 1 Abstract

PI_NAMEs: ANDERSON, MARK S;BUCKNER, JANE HOYT (contact)

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Allergic Disease;Area;Autoimmune Diseases;Autoimmunity;burden of illness;California;clinical application;Clinical assessments;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Communities;data integration;data management;data sharing;design;Development;Discipline;Disease;drug withdrawal;empowerment;experience;flexibility;Fostering;Freedom;Funding;Future;Genetic;Goals;Health;Health Care Costs;Hypersensitivity;Immune Tolerance;Immunologics;Immunology;improved;Industry;innovation;Institution;Intervention;Knowledge;Laboratories;Lead;Leadership;Life;Medical;Mission;National Institute of Allergy and Infectious Disease;next generation;novel;operation;Organ failure;Phase;Population;preclinical study;Process;programs;Quality of life;Research Design;Research Institute;Research Personnel;Resource Sharing;Resources;Role;Sampling;San Francisco;Structure;success;Therapeutic;Therapeutic immunosuppression;tool;Transplantation;treatment response;trial planning;United States;Universities

PROJECT_TITLE: Immune Tolerance Network


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Pediatric

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: This project addresses a number of issues that of central importance for understanding how behavioral set-points for motivated behaviors are regulated during the critical transition between adolescence and full maturity. Specifically, using a mouse model, this project will examine how serotonin, acting through 5-HT1A receptors affects maturation of medial pre-frontal cortex dependent circuitry in adolescence to affect lifelong motivational states. This work has implications for our understanding of human conditions where motivation is dysregulated such as depression, and may reveal new developmentally specific approaches to treating such problems.

PI_NAMEs: LEONARDO, EDUARDO DAVID (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Agonist;Animal Model;Animals;Anxiety;Behavior;Behavioral;Brain;Cells;Child;Childhood;Costs and Benefits;Data;Dependence;designer receptors exclusively activated by designer drugs;Desire for food;Development;Disease;dorsal raphe nucleus;Drug Modulation;experimental study;Fiber;Future;gain of function;Goals;hedonic;hippocampal pyramidal neuron;Human;in vivo;Intervention;Life;Link;Literature;loss of function;mature animal;Medial;Mediating;Mental Depression;Mental disorders;Moods;motivated behavior;Motivation;mouse model;Mus;Nature;neuronal excitability;Neurons;neuroregulation;Outcome;Pathway interactions;Pharmaceutical Preparations;Photometry;Physiological;Physiology;Population;postnatal development;Prefrontal Cortex;Property;Psychological reinforcement;receptor;receptor function;response;Rewards;Schizophrenia;Serotonergic System;Serotonin;Serotonin Receptor 5-HT1A;Signal Transduction;Slice;Stimulus;stressor;Syndrome;System;Taxes;Testing;Time;willingness;Work

PROJECT_TITLE: Adolescence, motivation and the maturation of the prefrontal cortex.


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Recent clinical studies have shown that the bleeding disorder hemophilia, which occurs in 1 of 5,000 male births worldwide, can be cured by gene therapy. Surprisingly however, the gene therapy has not been stable. Basic scientific studies are needed to fill in critical knowledge gaps, so that a safe and lasting cure of the disease can be achieved.

PI_NAMEs: HERZOG, ROLAND W. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: adaptive immune response;Address;amyloid formation;Attention;Basic Science;Biology;Birth;Blood Coagulation Disorders;Blood Coagulation Factor;Cells;Cellular Stress;Clinical Research;Clinical Trials;Commercial Sectors;Communities;design;Development;Disease;DNA;Dose;Elements;endoplasmic reticulum stress;Event;experience;F8 gene;Factor VIII;gene therapy;Gene Transfer;Generations;Genetic Recombination;Genome;Goals;Grant;Hemophilia A;Hepatic;Hepatocyte;Hepatotoxicity;Human;Human Biology;Immune;Immune response;Immune system;Immune Tolerance;Immunobiology;Immunology;improved;In Vitro;in vivo;Individual;innate immune mechanisms;Innate Immune Response;Insertional Mutagenesis;Investigation;Knowledge;Link;Liver;male;Molecular;Molecular Analysis;Molecular Virology;mouse model;Normal Range;nuclease;Outcome;particle;Patients;Pharmacotherapy;Phase III Clinical Trials;Positioning Attribute;Probability;Production;programs;protein misfolding;Proteins;Protocols documentation;Research Personnel;response;Role;Safety;Steroids;Structure;Testing;Therapeutic;Time;Toxic effect;Transfer Factor;Transgenes;Translations;United States Food and Drug Administration;Variant;vector;vector genome;Viral;Viral Genes;Viral Vector

PROJECT_TITLE: Toward Safer Gene Therapy for Hemophilia A

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Pneumonia remains the #1 killer of children in the world and is a leading cause of morbidity and mortality in children in the US and the #8 cause of mortality in adults. This proposal will conduct research to better understand host resistance against pneumonia that can be used to develop new therapies or vaccines to prevent or treat pneumonia.

PI_NAMEs: KOLLS, JAY K (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Adult;Area;Bacterial Pneumonia;CD209 gene;CD4 Positive T Lymphocytes;Cells;Child;cytokine;Granulocyte-Macrophage Colony-Stimulating Factor;Host Defense;Host resistance;IL17 gene;Immunity;insight;interleukin-21 receptor;interleukin-22;Laboratories;Lung;Memory;Morbidity - disease rate;mortality;novel;novel therapeutics;novel vaccines;pathogen;Pathway interactions;Pneumocystis;Pneumonia;pneumonia treatment;prevent;Protein Isoforms;Research;Role;Seminal;STAT3 gene;Testing;Tissues


PROJECT_TERMS: Advisory Committees;Award;Cell Therapy;Communities;Conflict (Psychology);data access;Data Collection;Documentation;Electronics;experience;Experimental Models;Fostering;gene therapy;Hemophilia A;Human Resources;IACUC;Indiana;Institution;Internet;Laboratories;Leadership;Logistics;medical schools;meetings;member;National Heart, Lung, and Blood Institute;Outcome;Pediatric Research;Peer Review;Preparation;programs;Progress Reports;Protocols documentation;Publications;Published Comment;Reagent;Reproducibility;Research;Research Personnel;Resolution;Series;Structure;symposium;Training;Universities;Writing

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hematology;Liver Disease;Rare Diseases

PI_NAMEs: DE JONG, YPE PETER (contact)

PROJECT_TERMS: Address;Animals;Biology;Blood Coagulation Factor;Breeding;cDNA Library;Cells;Chimerism;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR/Cas technology;Cryopreservation;Engraftment;experience;experimental study;F8 gene;fetal;Fetal Liver;gene therapy;Gene Transfer;Genes;Genetic Engineering;genetic manipulation;Harvest;Hematopoietic stem cells;Hemophilia A;Hepatic;Hepatocyte;Hepatocyte transplantation;Hepatotoxicity;Human;humanized mouse;Immune;immune activation;Immune response;Immune system;Immunobiology;Immunocompetent;immunodeficiency;In Vitro;in vivo;Institution;Investigation;Knock-out;Kupffer Cells;Lentivirus Vector;Liver;liver injury;male;Modeling;Molecular;Mus;Natural Killer Cells;overexpression;Plasma;preservation;Process;programs;Rag1 Mouse;Research Personnel;response;retransplantation;RNA analysis;Safety;Services;single-cell RNA sequencing;System;Therapeutic;Tissues;Transgenic Organisms;Transplantation;two-dimensional;vector;Viral;Viral Genes;Viral Vector

PROJECT_TITLE: Human Hepatocyte and Discovery Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Discrete neuronal activity patterns define how information is processed in the brain. The manner in which disruption of these patterns by disease-associated mutations impacts behavioral regulation is poorly understood, but likely contributes to the etiology of many symptom domains of mental illness. We will use advanced genetic techniques coupled with in vivo and ex vivo electrophysiology and behavior to establish how distinct potassium channels implicated in neurodevelopmental disorders impact dopamine neuron physiology and function.

PI_NAMEs: ZWEIFEL, LARRY S (contact)

PROJECT_TERMS: Action Potentials;Acute;Address;Affective;autism spectrum disorder;aversive conditioning;Behavior;Behavioral;Biological Models;Brain;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Coupled;design;Dimensions;Disease;DNA Sequence Alteration;Dopamine;dopamine system;dopaminergic neuron;Electrophysiology (science);Elements;Etiology;experimental study;Gene Silencing;Generations;Genes;Genetic;Genetic Techniques;Goals;Human;in vivo;information processing;insight;Ion Channel;Lead;Learning;loss of function;Mediating;Memory;Mental disorders;Methodology;Midbrain structure;mosaic;Motivation;Mutagenesis;Mutation;Nature;neural circuit;neural network;Neurodevelopmental Disorder;Neurons;neurotransmitter release;Neurotransmitters;operation;optogenetics;Outcome;patch clamp;Pattern;Phase;Phenotype;Physiological;Physiology;Play;Potassium Channel;Process;Property;rare variant;Regulation;Regulatory Element;Rewards;Role;Schizophrenia;Sensory;Slice;Symptoms;Synapses;System;Ventral Tegmental Area;Viral;Viral Vector;virtual;voltage

PROJECT_TITLE: Phasic dopamine and symptom domains of mental illness

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases

PI_NAMEs: XIAO, WEIDONG  (contact)

PROJECT_TERMS: adeno-associated viral vector;Baculoviruses;Bioinformatics;Biological Assay;Cells;Clinical;Clinical Trials;Data;Data Analyses;Data Collection;data integration;design;Development;digital;Dose;Enzyme-Linked Immunosorbent Assay;experimental study;Factor VIII;Future;Gene Delivery;gene therapy;Gene Transduction Agent;Gene Transfer;Genome;genome analysis;Goals;Hemophilia A;Hepatic;Human;Immune system;improved;In Vitro;in vivo;innovation;Insecta;Knowledge;manufacturing process;manufacturing quality;manufacturing systems;manufacturing technology;Methods;Molecular;Molecular Virology;next generation sequencing;novel;Outcome;particle;Patients;Performance;Pharmaceutical Preparations;Plasmids;Population Analysis;Preparation;Production;programs;Property;Quality Control;Role;Safety;Scientist;Sequence Analysis;Series;Silver Staining;Southern Blotting;success;System;tool;transcriptome;Transfection;vector;vector control;Vertebral column;Viral

PROJECT_TITLE: Molecular Virology Core


PI_NAMEs: KAUFMAN, RANDAL J. (contact)

PROJECT_TERMS: Address;adenovirus mediated delivery;Adverse effects;Affect;Amino Acids;Apoptotic;B-domain-deleted factor VIII;Biochemical Process;biological adaptation to stress;Blood Coagulation Disorders;Blood Coagulation Factor;Bypass;Cell Culture Techniques;Cell Death;Cell Physiology;Cell secretion;Cells;Cellular Stress;Cessation of life;Chronic;Clinical;Coagulation Process;Complement Factor B;Coupled;Defect;Dependovirus;design;Development;digital;Dose;Ectopic Expression;Endoplasmic Reticulum;Engineering;enhancing factor;Exhibits;Factor IX;Factor VIII;Family suidae;Fatty Liver;gene therapy;gene therapy clinical study;Gene Transfer;Genes;Goals;Grant;Hemophilia A;Hemorrhage;Hepatocarcinogenesis;Hepatocyte;High Fat Diet;Human;human disease;human model;humanized mouse;improved;in vivo;Individual;Inflammatory Response;Injections;insight;interest;Knowledge;Lead;Link;liver injury;male;Mediating;Messenger RNA;Monitor;mouse model;Mus;novel;plasmid DNA;Population;Post-Translational Protein Processing;Preparation;prevent;Primary carcinoma of the liver cells;Process;Production;prophylactic;Protein Biosynthesis;protein misfolding;Proteins;Reactive Oxygen Species;response;ribosome profiling;Safety;single-cell RNA sequencing;Stress;systemic inflammatory response;Tail;Testing;Therapeutic;therapeutic transgene;Time;Toxic effect;transcriptomics;transgene expression;Translating;Translations;Transplantation;Variant;vector;Veins;X Chromosome

PROJECT_TITLE: Overcoming FVIII protein misfolding and cell toxicity


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Findings from the proposed research are important for furthering women’s options for management of fistula- related urinary incontinence and are expected to inform changes to clinical practice for fistula management in low- and middle-income countries. Ultimately, expanding management options for women with fistula is likely to reduce stigma, improve economic opportunity, and have a transformative effect on quality of life. By prioritizing global implementation research early in the interventional research process, culturally appropriate, cost-effective, and acceptable implementation strategies can be planned for this and similar contexts.

PI_NAMEs: EL AYADI, ALISON M (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;Atopobium vaginae;Caring;Clinical;clinical practice;Clinical Trials;Collection;Communities;Community Health Aides;comparative effectiveness;Consolidated Framework for Implementation Research;coping;cost;cost effective;cost effectiveness;Cross-Over Trials;Crossover Design;Data;design;Device Designs;Devices;Direct Costs;Discipline of obstetrics;Economic Burden;economic impact;Economics;Effectiveness;effectiveness evaluation;effectiveness measure;Epidemiology;evidence base;Extravasation;Face;Facilities and Administrative Costs;Feasibility Studies;Fistula;follow-up;Future;Ghana;Goals;Health behavior;health economics;Home;implementation research;implementation science;implementation strategy;implementation study;improved;Incontinence;Individual;International;Intervention;Intervention Studies;Interview;Leg;Longitudinal Surveys;low and middle-income countries;maternal morbidity;Measures;Medical;Methods;microcosting;Midwife;Modeling;Modification;Motion;Nurses;obstetric fistula;Operative Surgical Procedures;opportunity cost;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;peer;Practice Management;Prevention;Process;Productivity;prototype;Provider;Quality of life;Randomized;repaired;Reporting;Research;Resources;Risk Reduction;Rubber;Secure;Self Efficacy;Silicones;Site;Social Impacts;social stigma;socioeconomics;standard of care;Surveys;tertiary prevention;Testing;Textiles;theories;Therapeutic;Time;Time and Motion Studies;time use;Tube;uptake;urinary;Urinary Fistula;Urinary Incontinence;Urine;Vagina;Woman;Work

PROJECT_TITLE: Effectiveness and acceptability of two insertable device models for non-surgical management of obstetric fistula in Ghana: a randomized crossover trial

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Adenoviruses;Affect;Back;Bioinformatics;biological adaptation to stress;Biology;Birth;Blood Coagulation Disorders;canine model;Cells;Circulation;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Data Analyses;Defect;Dependovirus;design;Development;DNA;DNA lesion;Double-Stranded RNA;Elements;enzyme replacement therapy;F8 gene;Factor VIII;Gene Delivery;gene therapy;Generations;Genes;Genome;genotoxicity;Goals;hazard;Hemophilia A;Hemorrhage;Human;Immune response;Inherited;Integration Host Factors;Knowledge;Lead;Lesion;Libraries;Ligase;Ligation;Link;Longitudinal Studies;male;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;next generation;Nonhomologous DNA End Joining;novel;Nucleotides;Oncogenic;Outcome;particle;Pathway interactions;Phenotype;Population;Process;Production;promoter;Promoter Regions;Proteins;Quality Control;Reaction;Recombinant adeno-associated virus (rAAV);Research;Risk;Role;Running;Safety;single molecule;Southern Blotting;System;tool;vector;vector genome;Viral;Viral Genome;Viral Packaging;Virus Replication;XRCC5 gene

PROJECT_TITLE: Biology of Subgenomic AAV Vector Particles


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: SCOTT, EMILY E (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Active Sites;Adopted;alpha helix;Area;Bile Acids;Binding;Chemicals;Collaborations;Complex;Cryoelectron Microscopy;Crystallization;CYP17A1 gene;CYP2S1 gene;CYP3A4 gene;Cytochrome P450;Cytochromes;Data;Data Set;Disease;Eicosanoids;Electrons;Engineering;Enzymes;Face;Fatty Acids;flexibility;Goals;Grant;Hand;Human;Human body;human disease;Individual;inhibitor;interest;Label;Ligand Binding;Ligands;Membrane;Membrane Proteins;Molecular Conformation;Oxidation-Reduction;Oxidoreductase;Pathway interactions;Pharmaceutical Preparations;Play;prevent;Proteins;Qualifying;Research;Resolution;Roentgen Rays;scaffold;small molecule;structural genomics;Structure;Substrate Specificity;success;Surface;Synthetic Genes;System;Techniques;tool;Toxin;toxin metabolism;Visualization;Vitamins;X-Ray Crystallography

PROJECT_TITLE: Structural Basis of Cytochrome P450 Activity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;adeno-associated viral vector;Antibody Formation;Back;Basic Science;Biology;Blood Coagulation Disorders;Blood Coagulation Factor;Cells;Cellular Stress;Clinical Trials;Coagulation Process;Codon Nucleotides;Complex;cytokine;Cytokine Signaling;Data;design;Disease;Dose;Double-Stranded RNA;endoplasmic reticulum stress;experimental study;F8 gene;Factor IX;Factor VIII;gene product;gene therapy;Gene Transfer;Genes;Genome;Grant;Hemophilia A;Hemophilia B;Hemostatic function;Hepatic;Hepatocellular Damage;Hepatocyte;Hepatotoxicity;Heterogeneity;Human;Immune;immune activation;Immune response;Immune signaling;Immune system;Immune Tolerance;Immunity;Immunocompetent;Immunology;immunoregulation;improved;in vivo;Inflammation;Inflammatory Response;Injections;innate immune pathways;Innate Immune Response;Intervention;Investigation;Link;Liver;Medicine;Modality;Molecular;mouse model;Mus;Natural Immunity;Normal Range;Outcome;overexpression;particle;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Physiological;polypeptide;preservation;Problem Sets;Production;Protein Biosynthesis;Proteins;Protocols documentation;Published Comment;Receptor Signaling;Reporting;response;Risk;Safety;Scientific Inquiry;Serotyping;Shapes;Signal Transduction;Steroids;System;Therapeutic;Toxic effect;Transgenes;Variant;vector;vector genome;Viral;Viral Genes;Viral Vector

PROJECT_TITLE: Mechanisms of Innate and Adaptive Immune Responses to AAV-FVIII Gene Transfer


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Diaphragm vascular dysfunction portends and contributes to the diaphragm atrophy and contractile dysfunction associated with prolonged mechanical ventilation (MV) and such diaphragm muscle abnormalities (e.g. atrophy, contractile dysfunction) are present in heart failure (HF), however, the role of diaphragm vascular dysfunction in HF, as well as the impact of HF with the added insult of prolonged MV on diaphragm vascular function, has never been investigated. Therefore, using a unique combination of techniques (fluorescent microspheres, isolated blood vessel preparation, contractility measures), the current proposal will determine the distribution of diaphragm blood flow and diaphragm vasomotor function in HF and HF + prolonged MV as well as the efficacy of pharmacological treatment (Angiotensin-(1-7)) to improve diaphragm blood flow, vascular function, and in vivo contractile function with prolonged MV and HF + prolonged MV rats. Diaphragm vascular function is a neglected field of research in both health and disease and yet preventing the harbingers of respiratory muscle failure, if possible, will do much to lessen the human burden of major pathologies such as HF and COVID-19.

PI_NAMEs: HORN, ANDREW  (contact)

PROJECT_TERMS: Acetylcholine;Anatomy;angiotensin I (1-7);Angiotensin II;Animal Disease Models;arteriole;Artificial Heart;Atrophic;Blood flow;Blood Vessels;Breathing;Cardiovascular system;career;Cause of Death;Cholinergic Agonists;Clinical;COVID-19;Critical Thinking;Data;Development;Disease;Educational process of instructing;Elements;endothelial dysfunction;Endothelium;Environment;exercise intolerance;Exhibits;experimental study;Failure;Fatigue;frontier;Functional disorder;Goals;Health;Heart Diseases;Heart failure;Human;Hyperemia;Impairment;improved;in vivo;Infusion procedures;insight;Intervention;Kansas;Kinesiology;Knowledge;Laboratories;Measurement;Measures;Mechanical ventilation;Medial;Mediator;Messenger RNA;Microspheres;mortality;Muscle;Muscle Fatigue;Muscle function;Myocardial Infarction;neglect;NG-Nitroarginine Methyl Ester;novel;Outcome;Oxygen;Pathology;Pathway interactions;patient population;Patients;Perfusion;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physiology;Predisposition;Preparation;preservation;prevent;protein expression;Quality of life;Rattus;Receptor Activation;Regulation;Relaxation;Renin-Angiotensin System;Research;Resistance;Respiratory Diaphragm;Respiratory Muscles;response;Role;Skeletal Muscle;skills;Techniques;Testing;Time;Training;United States;Universities;Vascular Diseases;Vascular resistance;Vasodilation;Vasodilator Agents;Vasomotor;Ventilator;Weaning

PROJECT_TITLE: ROLE OF ANGIOTENSIN-(1-7) AND DIAPHRAGM VASCULAR FUNCTION IN HEART FAILURE AND PROLONGED MECHANICAL VENTILATION


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative How cognition and brain function stabilize in the transition from adolescence to adulthood is not understood limiting our understanding of the formation of normative and importantly non-normative adult trajectories, such as in mental illness, which predominantly emerges during this transition. Here, informed by the important results of the earlier grants in this line of inquiry regarding brain development in the reward system, we propose innovative new studies to understand how changes in brain and reward behavior from adolescence to adulthood lead to retaining established behaviors. Together, these studies will provide new integrated evidence of how brain development leads to establishing adult trajectories informing impaired trajectories in mental illness.

PI_NAMEs: LUNA, BEATRIZ  (contact)

PROJECT_TERMS: Acceleration;addiction;Adolescence;Adolescent;Adult;Age;age related;Animal Model;Attenuated;attenuation;Behavior;Behavioral;Brain;brain tissue;Buffers;Childhood;childhood epilepsy;Cognition;cognitive control;cohort;Collaborations;Corpus striatum structure;Data;Decision Making;design;Development;Dopamine;Electroencephalography;Epilepsy;Event;Excision;executive function;Functional Magnetic Resonance Imaging;Goals;Grant;habit learning;Habits;Hippocampus;Human;Human Development;Impairment;Implanted Electrodes;improved;innovation;insight;Iron;Lead;learned behavior;Learning;Magnetic Resonance Imaging;Measures;Mediating;Mental disorders;Modeling;Mood Disorders;motivated behavior;Motivation;motivational processes;Nature;neural;neurobehavioral;Neurocognitive;neurodevelopment;neuromechanism;neurophysiology;Neurophysiology - biologic function;Neurosurgeon;neurosurgery;novel;operation;Operative Surgical Procedures;Participant;Patients;Pediatric cohort;pediatric patients;Positron-Emission Tomography;Preparation;Process;Psychopathology;Psychoses;receptor;recruit;Research Personnel;reward processing;Rewards;Rodent Model;Role;Schizophrenia;Substance Use Disorder;System;Testing;Time;transition to adulthood;young adult

PROJECT_TITLE: Adolescent striatal neurophysiological maturation underlying the transition to adult stabilization of behavior

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Brain Disorders;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

PHR: NARRATIVE 38 million people worldwide are living with HIV. Despite successful antiretroviral therapy (ART), 15-40% of these people with HIV develop HIV-associated neurocognitive impairments (HIV-NCI) that gravely impact morbidity and mortality, for which there is no effective therapy in the ART era. Since HIV-infected intermediate monocytes are major contributors to neuropathogenesis and the development of HIV-NCI, defining and characterizing novel subsets is paramount to identifying new targets for potential therapies.

PI_NAMEs: RUIZ, VANESSA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acute;Age related comorbidities;ALCAM gene;Antibodies;antiretroviral therapy;Atherosclerosis;Awareness;Blocking Antibodies;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;Brain;CCL2 gene;CD14 gene;Cell Physiology;Cell Separation;Cell Surface Proteins;Cells;Central Nervous System Infections;Characteristics;chemokine;Chronic;cytokine;Demyelinations;Development;Diagnosis;Disease;effective therapy;Environment;extend lifespan;FCGR3B gene;fibroglycan;Flow Cytometry;Fluorescence;Gene Expression;gene network;Genes;Heart failure;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;In Vitro;Individual;Inflammation;Inflammatory;Laboratories;Mediating;medication compliance;migration;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mortality risk;Myocardial Infarction;Myocardial Ischemia;neuroinflammation;Neuronal Injury;Neuropathogenesis;neurotoxic;novel;Pathogenesis;Pathologic;Pathway interactions;Penetrance;Persons;Population;Predisposition;Production;Property;Proteins;Quality of life;Quantitative Reverse Transcriptase PCR;RNA;single-cell RNA sequencing;synaptic pruning;therapeutic development;Tissue-Specific Gene Expression;transcriptome;Viral reservoir

PROJECT_TITLE: Characterizing subsets of HIV-infected and uninfected CD14+CD16+ monocytes that contribute to neuropathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-Z(20)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Human Genome;Rheumatoid Arthritis

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Macrophages are critical to the maintenance of healthy joints, but increased macrophage number is associated with inflammation in rheumatoid arthritis (RA). We propose to investigate macrophage heterogeneity and transcriptional regulation using mouse models and patient samples to better understand their dynamics in health and disease. These studies will elucidate the role of different macrophage subpopulations in RA and provide potential targets for therapeutic intervention.

PI_NAMEs: PERLMAN, HARRIS R (contact);WINTER, DEBORAH RACHELLE

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adopted;Adoption;Arthritis;ATAC-seq;Biopsy;Bone Marrow;cell type;Cells;Chimera organism;Clinical;combinatorial;cytokine;Data;Development;Dichloromethylene Diphosphonate;Disease;Environment;Enzymes;epigenomics;Exhibits;Exposure to;follow-up;functional genomics;Future;Gene Expression Profile;Genetic;Genomic approach;genomic profiles;Genomics;Growth;Health;Heterogeneity;Homeostasis;Immune;immune function;Immunologics;Impairment;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Infiltrate;interstitial;joint inflammation;joint injury;Joints;Knock-out;Knowledge;Label;Liposomes;Macrophage;Maintenance;minimally invasive;Modeling;Molecular;monocyte;mouse model;Mus;myocyte-specific enhancer-binding-factor 2C;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Population;prevent;Production;programs;PTPRC gene;recruit;Recurrence;Recurrent disease;Residencies;Resolution;Response to stimulus physiology;Rheumatoid Arthritis;Role;Sampling;Serum;Severities;side effect;single-cell RNA sequencing;Surface;Synovial Cell;Synovial Membrane;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcription factor;Transcriptional Regulation;treatment response;ultrasound;Visit;Work

PROJECT_TITLE: Macrophage Heterogeneity in Rheumatoid Arthritis


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many diseases have their origins prenatally and in childhood, making investment in research on pediatric disease and health an important goal for improving the health of people of all ages. While there is a critical need to advance the science related to childhood diseases and health and translate basic research findings into novel interventions, the numbers of physician-scientists devoted to these causes are stagnating. We propose herein an innovative program where renowned faculty with extensive research and training expertise will mentor outstanding junior pediatric faculty embarking on careers in academic medicine, and help them to become successful, independent physician scientists who conduct cutting-edge basic and translational research of importance to children.

PI_NAMEs: DEVASKAR, SHERIN U (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: career development;Child;Child Health;Childhood;Clinical;cohort;Communities;Development;Development Plans;disability;Entrepreneurship;Environment;Ethics;experience;Faculty;faculty mentor;flexibility;Fostering;Goals;Grant;improved;Individual;innovation;Institution;Intellectual Property;K-Series Research Career Programs;Leadership;medical schools;medical specialties;Mentored Clinical Scientist Development Program;Mentors;pediatrician scientist;Physicians;Preparation;Program Development;Program Evaluation;programs;Ramp;Research;Research Personnel;Research Training;Running;Scientist;Services;synergism;Teacher Professional Development;Technology;Training;training opportunity;Training Programs;Woman

PROJECT_TITLE: UCLA Child Health Research Career Development Award


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Genetics;Maternal Health;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Metformin use in pregnancy is associated with potential maternal benefits but also adverse neonatal and childhood outcomes. This projects seeks to study the effects of metformin on placental trophoblast function and potential epigenetic mechanisms that contribute to the detrimental offspring outcomes reported in the larger clinical trials. These data will add to the critical gap in our knowledge of the effects of metformin on placental health, role on potential beneficial and adverse perinatal outcomes, and inform future safety and targeted interventions for use of metformin in pregnancy.

PI_NAMEs: VALENT, AMY MIYOSHI (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Admission activity;Adverse effects;adverse outcome;Affect;Area;Birth Weight;Blood Glucose;blood lipid;Body System;cardiometabolism;Cell Differentiation process;Cell Proliferation;cell type;Cells;Chemicals;Child;Childhood;Clinical Trials;Communication;comorbidity;cytotrophoblast;Data;Diabetes Mellitus;DNA;DNA Methylation;Dose;Drug Exposure;Epigenetic Process;epigenomics;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Exposure to;fetal;Fetal Development;Fetal Growth;fetal programming;Fetus;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene function;Genes;Genetic Markers;Genetic Transcription;Gestational Age;Gestational Diabetes;gestational weight gain;Growth;Growth and Development function;Health;Homeostasis;Hormones;Human Chorionic Gonadotropin;Image;In Vitro;Inflammation;insight;Insulin;Intervention;Knowledge;Life Style Modification;Metabolic;Metabolism;Metformin;Methylation;Mitochondria;Morbidity - disease rate;Morphology;mRNA Expression;Neonatal;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;Obesity;offspring;Oral;organ growth;Outcome;Pathway interactions;peptide hormone;Perinatal;perinatal outcomes;Pharmaceutical Preparations;pharmacologic;Placenta;Placental Hormones;placental trophoblasts;Plasma;Polycystic Ovary Syndrome;Population;Pregnancy;Pregnancy Complications;prenatal exposure;Production;protein expression;Publishing;Reporting;Respiration;Risk;Role;Safety;Small for Gestational Age Infant;Syncytiotrophoblast;Testing;Time;transcriptomics;trophoblast;United States;Visual;Weight

PROJECT_TITLE: Metformin Effects Placental Trophoblast Function


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: The overall goal of this project is to develop a new class of antipseudomonal antibody bactericide conjugates (ABC) that can safely eliminate blood stream infections caused by P. aeruginosa. This research effort directly addresses a critical and unmet need for the development of alternative targeted and potent antibiotics against P. aeruginosa and its multidrug resistant variants.

PI_NAMEs: ALABI, CHRISTOPHER AKINLEYE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: absorption;Acceleration;Address;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotics;Antibodies;Antibody-drug conjugates;antimicrobial;antimicrobial resistant infection;Bacteremia;Bacterial Infections;bacterial resistance;bactericide;Bacteriolysis;Binding;Biological Availability;Biological Markers;Blood;Blood Circulation;cancer therapy;Cell Death;Cell membrane;Cells;Centers for Disease Control and Prevention (U.S.);chemotherapy;Chronic lung disease;Clinical;Clinical Research;clinically relevant;combat;comorbidity;cytotoxicity;design;Development;Dose Limiting;drug clearance;Enzymes;Fatality rate;FDA approved;Fluorescence Resonance Energy Transfer;Frequencies;Genes;Goals;Gram-Negative Bacteria;Hospitalization;Immune;improved;In Vitro;in vivo;Infection;Injury to Kidney;Integration Host Factors;Intravenous;Kidney;Kinetics;Laboratories;Lead;Libraries;Lipids;Lung infections;Marketing;Matrix Metalloproteinases;Measures;Metabolism;Modeling;mouse model;Multi-Drug Resistance;Mus;Mutagenesis;nephrotoxicity;Neutropenia;novel;pathogen;Patient-Focused Outcomes;Patients;Peptides;Pharmaceutical Preparations;Pharmacologic Actions;Pneumonia;Polymers;Polymyxin B;Polymyxin B resistance;Polymyxin Resistance;Polymyxins;Prodrugs;Property;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Research;residence;Resistance;Resistance development;resistant strain;Respiratory Tract Infections;Sepsis;Site;small molecule;Source;Stream;success;Surface;Surgical Wound Infection;Therapeutic immunosuppression;Thrombin;Time;Toxic effect;Urinary tract infection;Variant;Virulence;World Health Organization

PROJECT_TITLE: Development of Targeted Antipseudomonal Bactericidal Prodrugs

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Foodborne Illness;Immunization;Infectious Diseases;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE We will examine the toxicity of arsenic to the developing immune system in children exposed in utero and early life and how it affects their response to vaccination against Streptococcus pneumoniae. It is known that arsenic disrupts the development of immune T cells important in protecting children against airway infections, such as Streptococcus pneumonia. We will measure how arsenic impacts the response to vaccination and microbial communities in the upper airways and gut.

PI_NAMEs: BLOSSOM, SARAH J;PARVEZ, MUHAMMAD F (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accounting;adaptive immunity;Affect;Age;Air;Animal Model;Animals;Antibody Response;Antibody titer measurement;Arsenic;B-Cell Development;bacteriome;Bangladesh;Birth;Bone Marrow;booster vaccine;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cessation of life;Child;Childhood;cohort;Color;Communities;Complex;cytokine;Data;Dendritic Cells;Development;DNA Damage;DNA Repair;Dose;drinking water;early life exposure;effector T cell;Environmental Pollutants;epidemiology study;exposed human population;Exposure to;Flow Cytometry;Food;Genes;genotoxicity;global health;Goals;Granzyme;gut microbiome;gut microbiota;Health;Hospitalization;Human;Immune;immune function;Immune system;Immunity;Immunologic Markers;Immunology procedure;immunoregulation;Impairment;in utero;Incidence;Infection;Lead;Length;Life;Link;Lymphocyte;Measures;Mediating;Memory;metagenomic sequencing;Metagenomics;microbial;microbial community;microbiome;microbiota;monocyte;Morbidity - disease rate;mortality;Mothers;Nasopharynx;Outcome;Pathway interactions;perforin;Peripheral Blood Mononuclear Cell;Play;Pneumococcal vaccine;Pneumonia;Predisposition;Pregnancy;prenatal exposure;Production;Proliferating;Quantitative Reverse Transcriptase PCR;Regulatory T-Lymphocyte;Research;Resistance to infection;respiratory;Respiratory Tract Infections;response;Risk;Role;Shotguns;Signal Transduction;stem cells;Streptococcus pneumoniae;T cell differentiation;T-Cell Activation;T-Cell Development;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thymus Gland;Time;Toxic effect;Vaccination;vaccine efficacy;vaccine response;Vaccines

PROJECT_TITLE: Developmental Exposures to Arsenic: Pneumonia, Immunity, and Microbiomes (DEAPIM)

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE We are studying the process of blood vessel formation and trying to understand how the growth of endothelial cells, that form the lining of blood vessels, is regulated and to what extent this is necessary in order to develop a proper blood circulatory system. By defining factors that are needed for endothelial cell growth control and arterial-venous network development, we will gain insights needed to treat arterial-venous malformations, enhance neovascularization of injured tissues, and engineer circulatory networks from human stem cells that can be used for tissue engineering and regenerative medicine applications.

PI_NAMEs: GENET, GAEL ;HIRSCHI, KAREN KEMPER (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: angiogenesis;Arteries;ATAC-seq;Bioinformatics;Blood;Blood capillaries;Blood flow;blood vessel development;Blood Vessels;BMP4;candidate identification;Cardiovascular system;Cell Culture System;Cell Cycle;Cell Cycle Regulation;cell growth;Cell Proliferation;Chromatin;Clinical;clinically relevant;Data;Data Analyses;Data Set;Development;Disease;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Engineering;Ensure;Evaluation;FDA approved;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Growth;Hemorrhage;Hereditary hemorrhagic telangiectasia;Human;human model;human stem cell-derived;human stem cells;improved;In Vitro;in vivo;in vivo Model;inhibitor;injured;injury and repair;insight;malformation;Metabolic;migration;Modeling;Molecular;Mus;neovascularization;notch protein;novel;Nutrient;Oxygen;Pathology;Perfusion;Phenotype;postnatal;pre-clinical;prevent;Process;Regenerative Medicine;Regulation;repaired;replacement tissue;Reporter;response;Retina;Role;shear stress;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Structure;Telangiectasis;Testing;Tissue Engineering;Tissues;transcriptome sequencing;Tube;Tumor Angiogenesis;Up-Regulation;Vascular remodeling;Vascularization;vasculogenesis;Veins;Venous;Venous Malformation;venule;Waste Products

PROJECT_TITLE: Cell Cycle Control of Arterial-Venous Specification

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]