NIH_SPENDING_CATS: Hematology;Nutrition;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Vitamin K plays an essential role in the production of blood clotting factors and is important to other functions such as regulation of calcification by Matrix Gla Protein. Vitamin K is used by a protein called the gamma- glutamyl carboxylase, which modifies clotting factors and Matrix Gla Protein, and this work will determine how full modification is impacted by a genetic disease, called pseudoxanthoma elasticum-like. The drug warfarin (or coumadin) is used to interfere with vitamin K metabolism and reduces blood clotting in millions of people worldwide, and this study will determine how warfarin impacts the full modification of clotting factors and Matrix Gla protein.

PI_NAMEs: BERKNER, KATHLEEN LUCILE (contact);RUNGE, KURT W

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Active Sites;Affinity;Animals;Anticoagulant therapy;Anticoagulants;Binding;Binding Proteins;Biological Assay;Blood;Blood coagulation;Blood Coagulation Factor;calcification;Calcium Binding;carboxylate;carboxylation;Catalysis;Catalytic Domain;Cell secretion;Cells;Coagulation Process;cofactor;CRISPR/Cas technology;Data;Defect;dietary;Disease;Factor IX;Factor X;gamma-glutamyl carboxylase;Genetic Diseases;Glutamic Acid;Goals;Health;Hemorrhage;Hemostatic Agents;Human;Impairment;in vivo;Individual;innovation;insight;Link;Liver;Mammalian Cell;Maps;Mass Spectrum Analysis;matrix Gla protein;Mediating;Metabolism;Modification;Monitor;Mus;mutant;Mutation;novel;Osteogenesis;Outcome;Oxidoreductase;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Play;Post-Translational Protein Processing;Production;protein function;Protein Secretion;Proteins;Prothrombin;Pseudoxanthoma Elasticum;reduced vitamin K;Regulation;response;Role;Skin;soft tissue;Testing;Time;Tissues;virtual;Vitamin K;Waran;Warfarin;Work

PROJECT_TITLE: Impact of gamma-glutamyl carboxylase processivity on vitamin K-dependent protein modification and function in human health and disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: GALVESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases that can spread worldwide to threaten global public health. Many of these viruses originate in Africa, where they circulate in wildlife and mosquitoes. The West African Center for Emerging Infectious Diseases will monitor people in Senegal, Nigeria and Sierra Leone to detect infections with these and other emerging viruses, determine how these people become infected and why disease outcomes vary widely, then produce risk maps so that surveillance and control can be focused on the most important regions.

PI_NAMEs: WEAVER, SCOTT C (contact)

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Affect;Africa;African;Americas;Angola;Arboviruses;Arthralgia;arthropod-borne;Asia;bat-borne;biosecurity;burden of illness;Caribbean region;Central America;Chikungunya virus;Chiroptera;Chronic;Circulation;Clinical;Clinical Research;Collaborations;Communicable Diseases;congenital zika syndrome;Coronavirus;Country;Culicidae;Dengue;Dengue Virus;Diagnostic;Disease;Disease Outbreaks;Disease Outcome;Ebola;Ebola virus;Electronic Medical Records and Genomics Network;Emerging Communicable Diseases;emerging pathogen;emerging virus;enzootic;Epidemic;Etiology;Europe;exposed human population;Fever;field study;Filovirus;Florida;future outbreak;Goals;Guillain Barré Syndrome;Health Personnel;Hemorrhage;Hemorrhagic Fever with Renal Syndrome;Henipavirus;Hospitals;Human;human disease;Immune response;Immune System Diseases;improved;Indian Ocean;Infection;Infrastructure;International;Laboratories;Lassa Fever;Lassa virus;Maintenance;Maps;Medical;Mexico;Microcephaly;Middle East Respiratory Syndrome Coronavirus;Monitor;new outbreak;Nigeria;Nipah;novel virus;outbreak response;Outcome;pathogen;pathogenic virus;Pattern;Persons;Probability;programs;Public Health;public health emergency;Research Infrastructure;Risk;RNA;Rodent;Senegal;Severity of illness;Sierra Leone;Source;South America;Texas;Ticks;Time;Training;Training Programs;transmission process;Variant;vector;Viral;viral genomics;Viral Hemorrhagic Fevers;Virulence;Virus;Virus Diseases;Wild Animals;Yellow Fever;Zika Virus;ZIKV infection;Zoonoses


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: PROJECT NARRATIVE Campylobacter is the principal global cause of bacterial enteritis, and infections have been shown to be predominantly derived from poultry. This project will study the genomes of microbes to differentiate and determine the relative contribution from industrially produced and community reared poultry to human campylobacteriosis. The long-term goal of this project is to decrease the burden of drug resistant Campylobacter in human populations through the effective control of campylobacteriosis in poultry production and food processing.

PI_NAMEs: SCHIAFFINO, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Animals;Antibiotics;antimicrobial;Antimicrobial Resistance;Attention;Birds;Campylobacter;Campylobacter coli;Campylobacter infection;Campylobacter jejuni;career development;Chickens;Child;Childhood;clinically relevant;commensal microbes;Communicable Diseases;Communities;community based participatory research;Country;design;Development;Development Plans;Diarrhea;disease model;disorder control;Domestic Fowls;Drug resistance;Drug-resistant Campylobacter;Ecology;Enteritis;epidemiologic data;Epidemiologic Factors;Epidemiologist;Epidemiology;Etiology;Europe;Evolution;Exposure to;fluoroquinolone resistance;Food;Food Handling;Food Processing;Food Safety;Genome;genomic epidemiology;Genomics;global health;Goals;Guillain Barré Syndrome;Health;Household;Human;improved;Income;Individual;Industrialization;Infection;Intervention;K-Series Research Career Programs;Knowledge;Link;Location;low and middle-income countries;Macrolide-resistance;Macrolides;Measures;Mentors;Mentorship;Metagenomics;Methodology;microbial genome;microbial genomics;Microbiology;Molecular Epidemiology;Morbidity - disease rate;Multi-Drug Resistance;Nested Case-Control Study;Outcome;Paralysed;pathogen;Pediatric cohort;Peru;Peruvian;Policies;Population;Positioning Attribute;Poultry Products;priority pathogen;Production;programs;Public Health;Publications;Reporting;Research;Research Personnel;Resistance;Resource-limited setting;responsible research conduct;Risk Factors;Rotation;safety practice;Science;Scientist;Signal Transduction;Site;Source;Syndrome;System;Training;transmission process;undercooked;whole genome;World Health Organization;Zoonoses

PROJECT_TITLE: Genomic Epidemiology of Campylobacter in Poultry to Enable the Effective Control of Human Campylobacteriosis in a Middle Income Country

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Diabetes;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Type 2 diabetes affects nearly 1 in 3 NH residents, yet guidelines for the management of diabetes in NH are based on sparse evidence and do not adequately consider the impacts of comorbidities, especially Alzheimer's Disease and related dementias, on diabetes management. To improve the quality of care for vulnerable NH residents, it is critical to evaluate whether Alzheimer's Disease and related dementias increases the risk of developing hypoglycemia and hyperglycemia in NH residents and whether Alzheimer's Disease and related dementias alters the thresholds of hypoglycemia and hyperglycemia that can cause adverse geriatric outcomes. Our proposal will use fingerstick glucose measurements taken from routine clinical care and captured in the Veterans Affairs electronic health record system to examine the complex relationships between Alzheimer's Disease and related dementias, hypoglycemia, hyperglycemia, and adverse geriatric outcomes in NH residents.

PI_NAMEs: LEE, ALEXANDRA KATHRYN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Address;Adult;Affect;Aging;Alzheimer's disease related dementia;Attention;Behavior;Blood Glucose;career;career development;Caregivers;Caring;Clinical;clinical care;Cognition;cognitive function;comorbidity;Complex;Complications of Diabetes Mellitus;Crossover Design;Data;Data Set;Databases;Dementia;diabetes management;Diabetes Mellitus;Doctor of Philosophy;Elderly;Electronic Health Record;electronic health record system;Environment;Epidemiologist;Epidemiology;evidence base;experience;Expert Opinion;falls;Fingers;Frail Elderly;functional decline;Funding;Geriatric Assessment;Geriatrics;Glucose;Goals;Guidelines;Health;Health Services for the Aged;high risk;human old age (65+);Hyperglycemia;Hypoglycemia;Impaired cognition;improved;Incidence;Incontinence;Insulin;Link;Measurement;Measures;Medical;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;mid-career faculty;multiple chronic conditions;Neurology;Non-Insulin-Dependent Diabetes Mellitus;Nursing Homes;older adult;Outcome;Policies;Population;professor;Psychiatry;Quality of Care;Quality of life;Recommendation;Research;Research Design;Research Personnel;Risk;Severities;skills;Source;Structural Models;Symptoms;Syndrome;System;Testing;Time;Training;United States Department of Veterans Affairs;Universities;Urinary tract infection;Vulnerable Populations

PROJECT_TITLE: Contributions of Hypoglycemia and Hyperglycemia to Adverse Geriatric Outcomes in NH Residents with Diabetes and Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Chronic pain conditions affect a large portion of the population and are often refractory to treatment, largely due to gaps in current understanding of the underlying sexually dimorphic mechanisms producing, maintaining, and resolving chronic pain. Utilizing a novel animal model of pain chronification, this project seeks to elucidate male-specific mechanisms underlying the unique plastic changes occurring in each of these phases of pain chronification. In doing so, new targets for the prevention and treatment of chronic pain conditions will be identified.

PI_NAMEs: MCDONOUGH, KATHLEEN ERIN (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Adult;Affect;Amyloid beta-Protein;Animal Model;Area;Attenuated;Back;Brain-Derived Neurotrophic Factor;Capsaicin;central sensitization;Chronic;chronic back pain;chronic pain;chronic pain management;Chronic pain syndrome;chronic painful condition;Chronic Phase;control theory;Data;Development;effective therapy;Electrophysiology (science);exosome;Family;Female;Fiber;glial activation;Goals;healing;Impairment;Inflammation;Inflammation Mediators;injured;Injury;insight;interest;Interneuron function;Interneurons;Knowledge;Laboratory Research;lipid mediator;Lipids;Macrophage;Maintenance;male;Mass Spectrum Analysis;Mediating;Microglia;Modeling;Molecular;mouse model;neural circuit;Neuroglia;neuronal circuitry;Neurons;new therapeutic target;Nociception;Nociceptors;novel;Pain;pain chronification;Pain management;pain model;Pain Research;painful neuropathy;Pathway interactions;Peripheral;Phase;Phase Transition;Population;Postdoctoral Fellow;Prevention;Reactive Oxygen Species;Refractory;Research;Research Project Grants;Resolution;response;Role;sensory input;sexual dimorphism;Signal Pathway;Site;skills;Spinal;Spinal Cord;Spinal cord posterior horn;Spinal Ganglia;Synapses;Techniques;United States;Work

PROJECT_TITLE: Effects of macrophage-derived exosomes on dorsal root ganglion neurons in models of systemic pain


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Making errors is typically considered a nuisance, but in fact, errors provide critical information that can help make corrections and update expectations about future events in an uncertain and ever-changing world. The goal of this proposal is to understand the way that olivo-cerebellar circuits in the brain encode and process this all-important error information. This research aims to uncover fundamental principles and provide mechanistic insight that is particularly relevant for treating neurological disorders associated with cerebellar dysfunction, like ataxia and dystonia, as well as other neuropsychiatric disorders like ADHD, autism, and schizophrenia, that have been linked to deficient communication between the cerebellum and the rest of the brain.

PI_NAMEs: MEDINA, JAVIER F (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affective;Afferent Pathways;Animals;Anterior;Area;Ataxia;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Blinking;Brain;Brain region;Cell Nucleus;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Cerebral cortex;Code;Cognition Disorders;Cognitive;cognitive function;Communication;Communication impairment;Conditioned Stimulus;Cues;density;Disease;Dorsal;Dystonia;Educational process of instructing;Event;expectation;experimental study;eyeblink conditioning;Fiber;Future;Goals;Heterogeneity;Individual;Inferior;insight;Instruction;Learning;Link;Machine Learning;Mental Processes;Molecular Target;mossy fiber;Motor;motor control;motor learning;Movement;Mus;Nervous System Disorder;neural;Neurologic;neuromechanism;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel therapeutic intervention;Occupations;Olives - dietary;optogenetics;Pathway interactions;Play;Pontine structure;Prefrontal Cortex;Process;Protocols documentation;Purkinje Cells;Research;response;Rest;Role;Schizophrenia;Sensory;Short-Term Memory;Signal Transduction;Somatosensory Cortex;Source;Specificity;Stimulus;supervised learning;Syndrome;Testing;theories;Time;tool;Training;Update;Work

PROJECT_TITLE: Coding and processing of error signals in inferior olivary-cerebellar networks

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Emergency Care;Harm Reduction for Substance Misuse;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: This study will provide the largest, most comprehensive and publicly available dashboard to easily access data on US state and local laws regulating and enforcing harm reduction and access to drug paraphernalia, availability of harm reduction services, and overdose morbidity and mortality statistics. Using these resources, we will identify and make available evidence on the optimal combination of laws needed at the state and local level to reduce harms from overdoses, and the conditions that need to be put in place at the local level to maximize the impact of such laws.

PI_NAMEs: CERDA, MAGDALENA  (contact);DIMAGGIO, CHARLES

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Abate;Accident and Emergency department;Acquired Immunodeficiency Syndrome;Address;American;Area;Bayesian Modeling;Cessation of life;Characteristics;Cities;Communities;Complex;County;dashboard;Data;data access;Data Set;Data Sources;Databases;density;Documentation;drug distribution;Drug usage;economic indicator;Effectiveness;Emergency Care;Emergency medical service;Endocarditis;Epidemic;Goals;Grant;Harm Reduction;Hepatitis B;Hepatitis C;HIV;Hypertension;Individual;Infectious Skin Diseases;Information Systems;Injury;interest;Intervention;Investments;Joints;Law Enforcement;Laws;Legal;Level of Evidence;Life;Location;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mortality statistics;multiple data sources;Municipalities;Naloxone;naloxone dispensing;National Institute of Drug Abuse;Needle-Exchange Programs;operation;Opioid;opioid injection;opioid mortality;opioid overdose;Overdose;overdose death;overdose education;overdose prevention;Overdose reduction;Paper;Persons;Pharmaceutical Preparations;Pharmacy facility;Pneumonia;Policies;prevent;programs;Reporting;Research;Resources;Role;secondary analysis;service programs;Services;socioeconomics;spatiotemporal;Sterility;Surveys;Syringes;System;Testing;United States;US State;user-friendly;Vital Statistics

PROJECT_TITLE: Large Data Spatiotemporal Modeling of Optimal Combinations of Interventions to Reduce Opioid Harm in the United States

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE This proposal investigates the role of retrotransposons and endogenous retroviruses in Alzheimer’s and related dementias, using a Drosophila model as well as mammalian cell culture. The primary hypothesis that will be investigated is that retrotransposons and endogenous retroviruses, which are virus like elements that reside in the genome, are both upstream initiators and downstream mediators of the protein aggregation pathology that is seen in subjects with these disorders. The proposal makes use of well established Drosophila models of neurodegeneration that are relevant to Alzheimer’s Related Dementias. By use of these models and of cell culture, this proposal also will test the idea that retrotransposons and endogenous retroviruses contribute to the spread of disease between neurons and glial cells in the brain.

PI_NAMEs: DUBNAU, JOSHUA T (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Age;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Astrocytes;Brain;Cell Culture Techniques;Cell Death;Cells;Clinical;clinically relevant;Cultured Cells;Data;design;Diagnosis;Disease;Disease Progression;DNA Damage;Drosophila genus;Elements;Endogenous Retroviruses;Exhibits;experimental study;Face;Feedback;fly;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Genome;Human;human subject;in vivo;Infection;insight;Intervention;knock-down;Literature;Mammalian Cell;Mediator;Modeling;Movement;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuroglia;Neurons;novel;Onset of illness;Outcome;Pathology;Patients;perineural;Pharmaceutical Preparations;Physiological;Play;protein aggregation;protein TDP-43;proteostasis loss;Publications;Reporter;Retrotransposon;Retroviridae;Risk;RNA Sequences;Role;Site;stem;success;System;TDP-43 aggregation;Testing;Tissues;transmission process;Virus;Work

PROJECT_TITLE: Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Mature primary B cells can be modified ex vivo to express HIV broadly neutralizing antibodies (bnAbs) as functional antigen-receptors (bnBCRs). We have shown that durable bnAb responses can be elicited from these cells after immunization in wild type mice, suggesting that it may be possible to develop ‘Engineered B cell vaccines’ (EBcVs) as an functional cure or prophylactic strategy in humans. This proposal improves and characterizes EBcV function in the mouse model, and translates the approach for efficacy testing in rhesus macaques using the SHIV model of HIV infection.

PI_NAMEs: VOSS, JAMES EVEN (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Affect;Affinity;Animal Model;Animals;Antibodies;antibody engineering;Antibody Response;Antigen Receptors;Antigens;antiretroviral therapy;Autologous;B cell repertoire;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Lymphocytes;Cells;cellular engineering;Code;design;Development;efficacy testing;Engineering;evaluation/testing;experimental study;Failure;gene therapy;Genes;Genetic;Genome;genome editing;Goals;Hepatocyte;HIV;HIV envelope protein;HIV Infections;Human;Immune system;Immunization;Immunize;Immunocompetent;Immunoglobulin Constant Region;Immunoglobulins;improved;in vivo;Infection;Infection prevention;Light;Macaca mulatta;Memory;Modeling;mouse model;Multi-Drug Resistance;Mus;Muscle Cells;Mutation;neutralizing antibody;nonhuman primate;novel;Passive Immunization;pathogen;Patients;Physiological;prevent;Prevention strategy;Preventive vaccine;Process;Property;prophylactic;protective efficacy;prototype;Reproducibility;Research;research clinical testing;Research Design;response;SIV;Structure of germinal center of lymph node;success;System;Technology;Testing;Translating;Treatment Efficacy;Vaccinated;Vaccination;vaccination strategy;Vaccines;Variant;Viremia;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Neurosciences;Substance Misuse

ORG_DEPT: NEUROLOGY

PHR: Narrative We suggest that Transcranial Radio Frequency Stimulation (TRFS; 900 MHz to few GHz), when using appropriate frequency, power and stimulation regimes, can offer a safe experimental and clinical tool that can combine advantages of the existing noninvasive perturbation methods with potentially fewer side effects. We propose to examine the membrane, single unit, circuit, and circuit modification mechanism of TRFS. !

PI_NAMEs: BUZSAKI, GYORGY  (contact);SODICKSON, DANIEL K

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Affect;Animals;Automobile Driving;behavioral response;Brain;BRAIN initiative;Bypass;Cells;Cephalic;channel blockers;Clinical;Cochlea;Data;Dedications;Deposition;design;Disease;electric field;Electric Stimulation;electrical potential;electrical property;Electrodes;Electromagnetics;Electronics;Electrophysiology (science);Engineering;Equilibrium;Exclusion;Experimental Designs;experimental study;extracellular;Focused Ultrasound;Frequencies;Future;Glass;Goals;Health;Human;in vivo;Ion Channel;knowledge base;Measures;Mediating;Membrane;metallicity;Metals;Methods;Modeling;Modification;Monitor;Morphologic artifacts;Mus;Neurologic;neuronal circuitry;Neurons;Neurosciences;operation;optical imaging;Optics;Pattern;Peripheral;Physics;Physiological;Positioning Attribute;Qualifying;radio frequency;Rattus;Research;Research Personnel;response;Rodent;Safety;Science;Sensory;side effect;Structure;Techniques;Testing;Tissues;tool;Transcranial magnetic stimulation

PROJECT_TITLE: Non-invasive Radio Frequency Stimulation of Neurons and Networks


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Nanotechnology;Radiation Oncology;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Precision magnetic hyperthermia by integrating magnetic particle imaging Magnetic iron oxide nanoparticles (MIONPs) offer considerable potential for numerous biomedical applications. Our objective is to develop an integrated magnetic particle imaging/magnetic fluid hyperthermia workflow that incorporates imaging-guided treatment planning for small animal models.

PI_NAMEs: BULTE, JEFF W. (contact);IVKOV, ROBERT

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Algorithms;Animal Model;Animals;Biological;Biomedical Research;Breast Cancer Model;cancer therapy;candidate selection;Clinical;clinical application;Clinical Trials;clinically relevant;Colloids;Computer Models;Computer software;contrast enhanced;Contrast Media;detection sensitivity;Diagnosis;Effectiveness;Emerging Technologies;ERBB2 gene;European;Fiber Optics;Funding;Gel;Glioblastoma;Grant;Heating;Histology;Human;Hyperthermia;hyperthermia treatment;Image;image guided;Imaging technology;in vivo;instrumentation;iron oxide;iron oxide nanoparticle;Liver;Location;magnetic field;Magnetic fluid hyperthermia;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Measurement;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Methods;Modeling;Mus;nanoparticle;nanoparticle delivery;Nanotechnology;nanotheranostics;Normal tissue morphology;particle;Physiologic pulse;Positioning Attribute;pre-clinical;Property;Radiation therapy;Rattus;Rectum;Recurrence;Relaxation;Research Personnel;Resistance;Resolution;Sampling;sensor;Signal Transduction;Suspensions;System;Technology;technology development;Temperature;Testing;theranostics;Therapeutic;Therapeutic Effect;Thermometry;Time;Tissues;Toxic effect;Tracer;Transgenic Organisms;Treatment Efficacy;treatment planning;tumor;Tumor Burden;tumor growth;Validation;Visualization;Width;zeta potential

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Many disease susceptibilities are not caused by changes in the genes themselves, but rather by changes in their regulatory elements that control when and where the gene turns on and off during development. However, there are not currently high-throughput methods to understand the regulatory potential of DNA sequences during development, or how a mutation may change this function. We are developing such a method and expect this new method to lead to a better understanding of the genetic differences that lead to disease risk, and ultimately improve treatment options.

PI_NAMEs: LOWE, CRAIG BARRETT (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adopted;Biological Assay;Brain;causal variant;Cell Line;cell type;Cells;Code;Development;Disease susceptibility;disorder risk;DNA;DNA Sequence;Dolphins;Elements;Elephants;Enhancers;Exons;Gene Expression;Genes;Genetic;Genome;genome wide association study;Genomics;Goals;Haplotypes;Human;Human Genome;improved;Intention;Kangaroo;Laboratories;Lemurs;mammalian genome;Mammals;Methods;mouse model;Mutation;Pan Genus;Phenotype;Pongidae;Posture;Proteins;Regulatory Element;Research;Research Personnel;Resolution;Testing;Tissues;trait;Vertebral column;Work

PROJECT_TITLE: From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The long-term goal of this project is a paradigm shift for the management of residual limb volume from a socket size management strategy to a limb size management strategy.

PI_NAMEs: SANDERS, JOAN E. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Affect;Area;Carbon;Clinical;Cross-Over Studies;Devices;effectiveness evaluation;Elements;Ensure;Environment;experience;Fatigue;functional outcomes;Goals;Health;human tissue;improved;Laboratories;Life;Limb Prosthesis;Limb structure;Liquid substance;Measures;Mechanics;Metals;Monitor;Motor;new technology;novel;operation;Orthotic Devices;Outcome;Outcome Measure;Participant;Patient Self-Report;Patient-Focused Outcomes;Performance;Positioning Attribute;pressure;Procedures;Prosthesis;prosthesis wearer;prosthetic socket;Protocols documentation;Public Health;Quality of life;Recovery;Reporting;Research;residual limb;residual limb health;satisfaction;Secure;sensor;sensor technology;soft tissue;Soft Tissue Injuries;Standardization;System;Testing;Time;Upper Extremity;Walking

PROJECT_TITLE: Measuring in-socket residual limb volume fluctuation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative We often take for granted our ability to seamlessly combine movements of our limbs and hands with the sense of touch, yet neuroscientists do not yet have a good understanding of how this coordination is achieved. In the proposed work, we use the rat whisker system as a model to study how the muscles that allow movement, as well as the biomechanics of movement, guide the sense of touch. This work is important for two reasons: 1) it is one of the first examples of understanding the way the body and brain combine sensing and movement all the way from touch sensors to muscle control; and 2) it may help us understand why some infants and some elderly persons have trouble swallowing, chewing, and breathing.

PI_NAMEs: HARTMANN, MITRA J (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: 3-Dimensional;active control;Afferent Neurons;Anatomic Models;Anatomy;Animal Behavior;Area;Attention;Back;Behavior;Behavioral;behavioral study;Bilateral;biomechanical model;Biomechanics;Brain;Brain Stem;Breathing;central pattern generator;Childhood;Complex;Data;Deglutition;Deglutition Disorders;Elderly;Elements;experimental study;Exploratory Behavior;Exposure to;Face;Facial Muscles;Feedback;Freedom;Frequencies;Goals;Hand;Head;Histology;Infant;Investigation;kinematics;Laboratories;Limb structure;Magnetic Resonance Imaging;Mastication;Mechanics;microCT;Modeling;Morphology;Motion;Motor;motor control;Motor Cortex;Movement;MRI Scans;Mus;Muscle;Nervous System;neural;Neural Pathways;Neuromechanics;neuroregulation;Neurosciences;novel;Paper;Pattern;Periodicity;Persons;Plants;prevent;Qualifying;Rattus;Research Personnel;Rodent;Rodent Model;Role;sensor;Sensory;sensory cortex;Sensory Process;Side;Signal Transduction;simulation;Smell Perception;software systems;Speed;suckling;System;Tactile;Testing;three-dimensional modeling;Time;Touch sensation;Trigeminal System;Vibrissae;Work;X-Ray Computed Tomography

PROJECT_TITLE: Models of rodent facial musculature for the study of active tactile sensing

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This research proposal focuses on the development and application of state-of-the-art lambda dynamics free energy simulations to provide atomistic insights into the mechanisms and thermodynamics of protein–ligand drug resistance and protein–protein binding. This information will be used to guide the discovery and design of novel small molecule and protein therapeutics to address a variety of infectious and proliferative diseases. Algorithms from the field of artificial intelligence will also be investigated in tandem with lambda dynamics calculations to automate preclinical lead optimization.

PI_NAMEs: VILSECK, JONAH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Address;Affinity;Algorithms;Alzheimer's Disease;analog;Area;Artificial Intelligence;Binding;Binding Proteins;Chemicals;Clinical;combinatorial;Complex;computerized tools;computing resources;cost;Coupled;deep learning algorithm;design;Development;Disease;drug candidate;Drug Design;drug discovery;Drug resistance;Drug Targeting;Free Energy;functional group;Generations;Goals;guided inquiry;improved;insight;interest;Lead;lead optimization;Ligands;Machine Learning;Methods;Missense Mutation;Modeling;Modernization;Modification;Molecular;molecular dynamics;Multiple Myeloma;Mutation;novel;pre-clinical;Process;Property;protein protein interaction;Proteins;Research;Research Proposals;Sampling;Scientist;Side;simulation;small molecule;Specificity;Structure;success;System;Techniques;Technology;Testing;Therapeutic;therapeutic protein;Thermodynamics;tool;Work

PROJECT_TITLE: Tackling Multifaceted Drug Design Problems with Lambda Dynamics Based Technologies


NIH_SPENDING_CATS: Aging;Neurosciences;Sarcopenia

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Narrative: Age-related declines in muscle mass and function are important contributors to the major public health problem of frailty, which significantly increases the risk for debilitating falls and reduces mobility, independence, and quality of life among the elderly. The lack of understanding of mechanisms of muscle fiber weakness and loss represents a critical barrier to progress toward the development of successful interventions for ameliorating physical frailty and thereby improving quality of life for the elderly. Here we test the previously unstudied role of oxidized phospholipids (oxPLs) and oxylipins in mediating mechanisms of atrophy induced by loss of innervation to increase our understanding of the mechanisms underlying muscle loss and weakness that is critical for identifying therapeutic targets with maximum effectiveness.

PI_NAMEs: VAN REMMEN, HOLLY  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Affect;Age;age related;age-related muscle loss;Aging;Arachidonate 15-Lipoxygenase;Arachidonic Acids;Atrophic;Autophagocytosis;Cell Death;Cells;Data;Degradation Pathway;Denervation;design;Development;Diameter;Drug Metabolic Detoxication;effective intervention;Effectiveness;Elderly;Enzymes;experimental study;falls;frailty;Generations;Goals;healthspan;improved;In Vitro;in vivo;Individual;inhibitor;insight;Intervention;intervention effect;Knockout Mice;Link;lipid mediator;Lipid Peroxides;Measures;Mediating;Mediator;Membrane;Mitochondria;Mobility decline;Modeling;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle metabolism;Muscle Mitochondria;Muscle Weakness;Muscular Atrophy;nerve supply;novel;oxidation;oxidative damage;oxidized lipid;Pathway interactions;Pattern;pharmacologic;Phospholipase A2;Phospholipids;Population;prevent;Production;protective effect;protein degradation;proteostasis;Public Health;Publishing;Quality of life;response;Risk;Role;sarcopenia;successful intervention;Testing;therapeutic target;Wild Type Mouse;Work

PROJECT_TITLE: A novel role for oxidized lipid mediators as effectors of muscle atrophy and weakness in aging

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Healthcare-associated infections are a common post-cardiac surgical complication, impact a patient’s risk of morbidity and mortality and vary in rate across hospitals. Provider care delivery networks that support coordination of patient disease management and care optimization vary in their performance across hospitals and contribute to higher rates of postoperative infections in some settings. The objective of this proposal is to identify areas of intervention within care delivery networks that enhance infection outcomes after coronary revascularization and valve surgery by: (1) Evaluating provider care delivery networks as significant determinants of postoperative infections after cardiac surgery; (2) Developing a comprehensive understanding of structural barriers and facilitators to optimal care delivery and (3) Developing a best practices toolkit to address the impact of provider care delivery networks on infections after cardiac surgery.

PI_NAMEs: LIKOSKY, DONALD S (contact);PAGANI, FRANCIS D

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Understanding and Addressing Variation in Healthcare-Associated Infections After Adult Cardiac Surgery

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative  Neuron to (astro)glia communication is essential for brain functions and alterations of their communication has been commonly found in neurological diseases. Recently, Exosome signaling has emerged as a novel and important intercellular communication pathway in the CNS. This project will investigate the fundamentally important but currently lacking cell biology of the emerging exosomal miR-mediated neuron to glia communication. Outcome will provide much-needed cell biological knowledge and insights for understanding exosome signaling in neuron to glia communication. This new knowledge can significantly help understand how this pathway is involved in CNS diseases.

PI_NAMEs: YANG, YONGJIE  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adult;Affect;Astrocytes;Biochemical;Biological;Brain;Cell Communication;cell type;Cells;Cellular biology;Central Nervous System Diseases;cerebrovascular;Coculture Techniques;Communication;Complement 1q;Cre driver;Data;designer receptors exclusively activated by designer drugs;Development;Diameter;Early Endosome;Endosomes;Exercise;exosome;extracellular vesicles;fluorescence imaging;Genetic;Genetic Transcription;genome-wide;Glioblastoma;Glutamate Transporter;Human;Image;Immune;In Situ;In Vitro;in vivo;Injections;insight;intercellular communication;Knowledge;Label;Ligands;Malignant Neoplasms;Mediating;MicroRNAs;Modeling;Molecular;Molecular Biology;Monitor;Morphogenesis;Morphology;Motor Neurons;mouse genetics;Mus;myelination;Nervous System Disorder;Nervous System Trauma;Neurodegenerative Disorders;Neuroglia;Neurons;neurotransmitter release;notch protein;novel;Outcome;Pathologic;Pathway interactions;PHluorin;Physiology;Process;Publishing;receptor;Regulation;Role;Sampling;Signal Transduction;Spinal;Surface;Synapses;synaptic function;Synaptic Transmission;Testing;transcriptome;Vesicle;Virus

PROJECT_TITLE: Exosomal miRNA in neuron to astroglial communication in the CNS

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The overall aim of this study is to employ Community Health Workers (CHWs) to screen for depression in 30 Black churches and compare the effectiveness of Screening, Brief Intervention, and Referral to Treatment (SBIRT) (Intervention arm) to Referral As Usual (Control arm) on treatment engagement. We will assess patient-level outcomes (Mental-Health Related Quality of Life and depressive symptoms) at 3- and 6-months post-screening and conduct a mixed-methods process evaluation to assess multi-level facilitators and barriers of screening uptake. This research addresses the NIMH Division of Services and Intervention Research (DSIR) area of high priority to “employ strategic partnerships and community engagement / participation to enhance research capacity and infrastructure in underserved and diverse populations.”

PI_NAMEs: HANKERSON, SIDNEY H;WILLIAMS, OLAJIDE  (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: acute stroke;Address;Adult;African American;American;Area;arm;Behavior;Black church;Black race;brief intervention;Cardiovascular Diseases;care seeking;Caring;Certification;Chronic Disease;Church;Clergy;Client;Clinical;Cognitive;Communities;community engaged approach;community engagement;Community Health Aides;compare effectiveness;Consolidated Framework for Implementation Research;contextual factors;cost;Counseling;Data;depression education;depression model;Depression screen;depressive symptoms;Detection;disability;disabled;disabling disease;Disparity;Economically Deprived Population;effectiveness/implementation design;Ethnic Population;evidence base;Evidence based intervention;Evidence based program;experience;Funding;Health;health literacy;Health Personnel;health related quality of life;Health Services Research;help-seeking behavior;Hispanic;Hybrids;Influentials;Infrastructure;Institution;Intervention;Intervention Studies;Knowledge;Link;Malignant Neoplasms;Medical;member;Mental Depression;Mental Health;Mental Health Services;Methods;motivational enhancement therapy;National Institute of Mental Health;Neurology;novel;Outcome;Pamphlets;patient-level barriers;Patients;Persons;Pharmaceutical Preparations;Population Heterogeneity;primary care setting;primary outcome;process evaluation;Provider;Public Health;Questionnaires;racial disparity;racial population;Randomized;Randomized, Controlled Trials;Reporting;Research;research study;screening;screening and brief intervention;screening, brief intervention, referral, and treatment;secondary outcome;Site;social capital;social stigma;socioeconomics;Testing;Training;Training Programs;treatment arm;treatment comparison;treatment site;Trust;Underserved Population;United States National Institutes of Health;Universities;uptake;usual care arm;Visit;Work

PROJECT_TITLE: Community Partnered Approach to Implement Depression Screening in Black Churches

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences;Regenerative Medicine;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Retinal ganglion cell (RGC) transplant holds excellent promise in regenerating or replacing damaged retinal tissues to treat otherwise incurable eye diseases, but a low transplant success rate and inconsistent treatment efficacy hamper its clinical application in ophthalmology. In this project, the PI will develop OCT contrast agents to achieve longitudinal and non-invasive cell tracking in the eye, and use advanced imaging to understand and optimize the factors affecting RGC transplant efficacy.

PI_NAMEs: CHEN, FANG  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;Age related macular degeneration;Animals;Apoptotic;Area;Award;Behavior;beta Actin;Biocompatible Materials;Biological Assay;Biomedical Engineering;Blindness;career;Cell Count;Cell Therapy;Cell Transplantation;Cells;Charge;Clinic;clinical application;Communities;Contrast Media;Cornea;Data;design;diagnostic strategy;Disease;disease model;Engineering;experimental study;Eye;Eye diseases;Face;Faculty;Gel;Glaucoma;Goals;Gold;Image;imaging program;Immunohistochemistry;improved;In Vitro;in vivo;Inductively Coupled Plasma Mass Spectrometry;Injections;Injury;interdisciplinary collaboration;Investigation;Knowledge;Label;Laboratories;Lasers;Location;materials science;Mentors;Methods;Microglia;Modeling;Molecular;molecular imaging;Mus;nanoGold;nanoparticle;nanorod;Natural regeneration;Neonatal;Nerve Crush;Neurodegenerative Disorders;novel;novel diagnostics;Oils;Ophthalmology;Ophthalmoscopy;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Outcome;Patients;Peripheral;Phase;pre-clinical;preclinical study;Prevalence;Process;Prognosis;Reaction;repaired;Research;Research Personnel;Resolution;Resources;Retina;retinal damage;Retinal Degeneration;Retinal Ganglion Cells;retinal imaging;Rodent;Scanning;sight restoration;Signal Transduction;Silanes;Silicon;Silicon Dioxide;Site;skills;Structure of retinal pigment epithelium;success;Surface;Testing;Therapeutic;Thick;Thinness;Time;Tissues;tool;Training;Translating;Transplantation;transplantation therapy;Treatment Efficacy;Universities;uptake;Vision;Visualization

PROJECT_TITLE: Nanoparticle-Based Tracking of Retinal Ganglion Cell Transplant


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Precision Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: C. difficile is the leading cause of healthcare-associated infection, yet no single test or validated model is capable of reliably telling which patients are at risk of dying from the infection. New research suggests that a patient's immune system, and possibly other factors such as Binary Toxin, may be the key to understanding how they will respond to C. difficile. This work will combine known risk factors with new markers from the blood and stool into an integrated scoring system that predicts which patients will develop severe or life-threatening C. difficile infection.

PI_NAMEs: MADDEN, GREGORY RUSSELL (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: adverse outcome;anti-toxin;Antibiotic Resistance;Antibodies;Arizona;Award;biobank;Biological Markers;Biometry;Blood;career development;Cessation of life;Classification;Clinical;Clinical Data;Clinical Markers;Clinical Research;Clinical Trials Design;Clostridium difficile;Colectomy;Colorectal Surgery;Communicable Diseases;cytokine;Data;Data Science;Databases;Dedications;Development Plans;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Enteral;Environment;eosinophil;Epidemiologist;Epidemiology;experience;fecal transplantation;Feces;Funding;Goals;Health Sciences;Healthcare;healthcare-associated infections;Hospitalization;Hospitals;Host Defense;IL8 gene;Immune;Immune system;Immunity;Immunologic Markers;Immunologics;Immunology;Infection;Innate Immune System;innovation;Institution;Interleukin-15;Interleukin-6;K-Series Research Career Programs;Lead;Life;Literature;Machine Learning;Master of Science;Measures;Mediating;Medical;Mentors;Metadata;Methods;Michigan;microbiome;Modeling;Molecular;molecular diagnostics;mortality;National Institute of Allergy and Infectious Disease;novel;novel marker;novel therapeutics;Operative Surgical Procedures;Organism;Outcome;outcome prediction;pathogen;Pathogenesis;Pathogenicity;Patients;Performance;Play;precision medicine;Predictive Analytics;predictive modeling;professor;prospective;Public Health Schools;RANTES;receptor;Research;Research Personnel;Resources;response;Risk;Risk Assessment;Risk Factors;risk stratification;Role;Schools;Science;Sepsis;Serum;specific biomarkers;Standardization;Statistical Models;stool sample;System;Techniques;Testing;Therapeutic;Time;TNF gene;Toxin;Training Activity;translational scientist;Universities;Virginia;Work

PROJECT_TITLE: Immune profiling to stratify Clostridioides difficile infection outcomes

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative, Public Health Relevance Statement Two existential threats to female fertility include the premature loss of the ovarian reserve and early implantation/placentation failure. Notably, these issues are among the least understood with regard to female fertility, which likely explains their continued threat and highlights the need for further investigation. Our studies are designed to discover how Iroquois homeobox proteins mediate germline nest breakdown and primordial follicle formation to establish responsive follicles with healthy oocytes and decidualization that promotes a successful implantation and placentation program.

PI_NAMEs: BAGCHI, INDRANI C;JORGENSEN, JOAN S (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Ablation;Adult;beta catenin;Biology;Cell Communication;Cell Differentiation process;cell motility;Cell Nucleus;cell stroma;Cells;Cytoplasm;Cytoskeletal Proteins;Cytoskeleton;Data;Decidual Cell;Decidual Cell Reactions;Defect;design;Development;Embryo;Embryo Deaths;Embryo Loss;Endometrial;Endothelium;Ensure;Event;Failure;Family;Female;female fertility;female reproductive tract;Fertility;Gap Junctions;Gene Modified;Genetic Transcription;Germ Lines;Goals;granulosa cell;Growth;Histology;Homeobox;Homeodomain Proteins;implantation;Investigation;Knock-out;Knockout Mice;Link;LoxP-flanked allele;Mediating;member;Modeling;Molecular;mouse model;Movement;Mus;mutant mouse model;natural Blastocyst Implantation;Nuclear;Oocytes;Outcome;Ovarian;ovarian reserve;Ovary;Ovulation;Pattern;Phase;Phenotype;Placentation;Play;Pregnancy;premature;Primordial Follicle;programs;protein function;Proteins;public health relevance;pup;Regulation;reproductive;response;Role;Series;Signal Pathway;Signal Transduction;Site;Somatic Cell;spatiotemporal;Stains;Stromal Cells;subfertility;System;Testing;Time;transcription factor;Transcriptional Regulation;trophoblast;Uterus;Vascularization;vasculogenesis;Work

PROJECT_TITLE: Iroquois function in the female reproductive tract

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PHYSICS

PHR: Project Narrative The adaptive immune system can mount a specific response against a multitude of pathogens, through molecular recognition grounded in complex biophysics of protein-protein interaction. The proposed project aims to develop data-driven approaches to characterize a representation of protein interactions in general, and of immune receptors, in particular. The learned representation reflects the relevant biophysical properties that determine a protein receptor’s stability, and function, and can be used to predict immune recognition and to design novel immune receptors and antibodies against a desired target.

PI_NAMEs: NOURMOHAMMAD, ARMITA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Adaptive Immune System;Address;Affinity;Amino Acids;Antibodies;B-Lymphocytes;Binding;Biological;Biological Process;biophysical properties;Biophysics;Catalytic Domain;cell type;Collaborations;Complex;Computer Models;Data;design;Framework Regions;generative models;Immune;Immune Targeting;Immunologic Receptors;innovation;Learning;Machine Learning;machine learning method;Molecular;molecular recognition;molecular shape;Neighborhoods;novel;pathogen;Property;protein function;protein protein interaction;protein structure;Protein Subunits;Proteins;receptor;response;Shapes;Specific qualifier value;Specificity;Structure;Surface;T-Cell Receptor;Techniques;Thinness;three dimensional structure

PROJECT_TITLE: Learning a molecular shape space for the adaptive immune system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Aging;Genetics

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Healthy aging and longevity depends on maintenance of cell phenotype and function and, in turn, cell type specific epigenetic programs. How cells sustain their epigenetic programs over the lifecourse is not known. We will test the existence of mechanisms of chromatin homeostasis – “chromostasis” – that maintain the epigenome, identify the genes involved and test their contribution to healthy aging.

PI_NAMEs: ADAMS, PETER D. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;age related biomarkers;age related decline;Aging;Alzheimer's Disease;ATAC-seq;Biological Assay;Breathing;candidate identification;Cardiac Myocytes;Cell Aging;Cell Maintenance;Cell Physiology;Cell Reprogramming;cell transformation;cell type;Cells;chemical genetics;Chromatin;Coin;Degenerative Disorder;Disease;Epigenetic Process;epigenome;Explosion;Fluorescence Resonance Energy Transfer;Genes;Genetic;Genetic Screening;Genetic screening method;Health;healthy aging;Heterogeneity;Histones;Homeostasis;Human;In Vitro;in vivo;innovation;insight;Intervention;Life Cycle Stages;life span;Logic;Longevity;Maintenance;Malignant Neoplasms;Measures;mutant;Mutation;Neurons;novel;Nucleosomes;Pathologic;Phenotype;Physiological;Predisposition;preservation;prevent;Process;programs;rate of aging;Rationalization;restraint;single cell technology;single-cell RNA sequencing;small molecule;Structure;Testing;Therapeutic;Time;Tissues;tool;transcriptomics;Variant

PROJECT_TITLE: Defining chromostasis - a candidate regulator of healthy aging and longevity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative  Chemical warfare agents such as mustards and arsenicals cause skin damage characterized by erythema, inflammation, and skin blistering, followed by a prolonged healing period. Although inflammatory cells and related cytokines are known to be increased in skin exposed to chemical agents, similarities and differences in the roles of these cells in skin damage caused by different agents, as well as subsequent healing, remain to be elucidated. The goal of this proposal is to develop capacity to study the role of the inflammatory response, particularly the macrophage response, using cutting edge single cell techniques, in mustard and arsenical skin injury. Ultimately, we plan to use knowledge generated by our research program to develop vesicant countermeasures that target the inflammatory response.

PI_NAMEs: KOH, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Anti-diabetic Drugs;Arsenicals;Bioinformatics;Biological Assay;Bone Marrow;Bulla;C57BL/6 Mouse;Cells;Chemical Agents;chemical countermeasure;chemical threat;Chemical Warfare Agents;cytokine;Data;Data Set;Development;Erythema;Experimental Designs;experimental study;Exposure to;FDA approved;Flow Cytometry;Future;Glyburide;Goals;Grant;healing;Host Defense;Human;Immunohistochemistry;improved;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;insight;Interleukin-1 beta;keratinocyte;Knockout Mice;Knowledge;Laboratories;lewisite;Macrophage;Mechlorethamine;Metabolic;Methods;Miniature Swine;Modeling;monocyte;Mus;Mustard;Mustard Gas;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;necrotic tissue;neutrophil;novel;Oral;Oxides;Pathway interactions;Play;programs;protocol development;Protocols documentation;prototype;receptor;Recording of previous events;repaired;Research;Research Contracts;Research Personnel;Resolution;response;Role;Safety;Sampling;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin damage;Skin injury;Skin repair;skin wound;Skin wound healing;Techniques;Testing;Therapeutic;tissue injury;tissue repair;Tissues;Training;United States National Institutes of Health;Up-Regulation;Vesicants;wound;wound healing;wound response

PROJECT_TITLE: The Role of Macrophages in Vesicant Skin Injury and Repair


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative  Optical coherence tomography angiography (OCTA) allows measurement of vessel density in the retina that provides novel information on retinal microvasculature associated with the development and worsening of glaucoma in a racially diverse cohort. We propose to improve detection and prediction of glaucomatous progression by disassociating age-related changes in OCTA measurements from glaucoma-related changes, by employing deep-learning analyses and by modifying predictive models by adding OCTA measurements. Enhanced detection of progression should lead to earlier and more effective treatment, thus reducing the rate of disease worsening and preventing loss of vision-related quality of life (including blindness).

PI_NAMEs: WEINREB, ROBERT N (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Age;age related;age related changes;Angiography;Area;Artificial Intelligence;Award;Blindness;Blood capillaries;Blood Vessels;Caring;Classification;Clinical;clinical care;clinical imaging;Clinical Trials;cohort;Complex;cost;Data;Data Set;deep learning;density;Detection;Development;Diagnosis;diagnostic accuracy;Disease;Disease Progression;Dropout;effective therapy;Evaluation;Eye;Eye diseases;Functional disorder;Funding;ganglion cell;Glaucoma;Global Change;Image;imaging modality;improved;Individual;Institutional Review Boards;instrument;Knowledge;Laboratories;Longitudinal Studies;Machine Learning;macula;Measurable;Measurement;Measures;Monitor;Multimodal Imaging;multimodality;novel;novel therapeutics;Open-Angle Glaucoma;Optic Disk;Optical Coherence Tomography;Patients;predictive modeling;prevent;Productivity;Publications;Quality of life;racial diversity;rate of change;Research;Retina;retina blood vessel structure;retinal nerve fiber layer;Risk;Risk Estimate;Risk Reduction;Science;Scotoma;Severity of illness;Specificity;statistical learning;Suspect Glaucomas;Testing;Thick;Time;Tissues;Vision;Visual Fields;Visual impairment;Visualization

PROJECT_TITLE: Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography Angiography


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Genetics;Heart Disease;Rare Diseases;Scleroderma

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: To improve treatment options for patients with scleroderma cardiomyopathy, a better understanding of the molecular and cellular mechanisms that cause this serious complication is needed. These studies will use patient-derived cells and rodent models of cardiac fibrosis to determine the role of the myeloid specific deficiency of transcription factor Fli1 in cardiac fibrosis, and if Rapamycin can be used to treat scleroderma cardiomyopathy. The results of this proposal will provide insights into the molecular mechanisms that are important in the cellular crosstalk between macrophages with low Fli1 and resident cardiac cells, thus establishing this transcription factor as a potential target for therapy.

PI_NAMEs: BUJOR, ANDREEA MONICA (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adult;Angiotensin II;Autoimmune;Autoimmunity;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cause of Death;Cell model;Cells;Cessation of life;Coculture Techniques;Collagen;Complication;Connective Tissue Diseases;coronary fibrosis;cytokine;Data;Deposition;Echocardiography;effective therapy;Endothelium;experimental study;Extracellular Matrix;Family;Fibroblasts;Fibrosis;FLI1 Transcription Factor;FRAP1 gene;Functional disorder;Future;gain of function;Galectin 3;Gene Expression;Genes;Genetic Recombination;Heart;Heart Diseases;Heterozygote;Human;Hypertrophy;Immune;improved;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Infusion procedures;inhibitor;injured;Injury;insight;Interferon Activation;Investigation;Link;Macrophage;Macrophage Activation;Mediating;Mediator;member;migration;Molecular;monocyte;mortality;mTOR inhibition;mTOR Inhibitor;mTOR Signaling Pathway;Mus;Muscle Cells;Myelogenous;Myeloid Cells;new therapeutic target;Nuclear RNA;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;prevent;Production;Proteins;Publishing;recruit;Reporter;repository;Research;response;Rodent Model;Role;Scleroderma;Serum;Signal Pathway;single-cell RNA sequencing;Sirolimus;Small Interfering RNA;System;Systemic Scleroderma;targeted treatment;Testing;Tissues;transcription factor;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: The role of Fli1 in myeloid cells and its contribution to cardiac fibrosis

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Lung;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This is a proposal to continue the UCLA Clinical Research Site (CRS) of the Multicenter AIDS Cohort Study ‐‐ (MACS) / Women's Interagency HIV Study (WHIS) Combined Cohort Study (CCS), which studies clinical,  ‐ ‐ ‐‐‐ immunologic, physiologic, behavioral, virologic, genetic and psychosocial changes in HIV infected and HIV uninfected men who have sex with men (MSM). The ongoing studies of the CCS will provide key information to advance our understanding of co-morbid and iatrogenic conditions occurring in people living with HIV infection (PLWH) receiving anti-retroviral therapy (ART), as well as inform the natural history of HIV at the molecular level, psychosocial determinants of disease and treatment compliance, and factors affecting optimal treatment of PLWH.

PI_NAMEs: DETELS, ROGER ;MIMIAGA, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;African American population;Age;Aging;aging biomarker;aging process;Alcohols;antiretroviral therapy;Area;attributable risk;Behavior;Behavioral;biobehavior;Biological Markers;Blood;Body Composition;Brain imaging;Cancer Survivorship;Cardiac;Cardiovascular Diseases;career;career development;Cessation of life;Characteristics;Cigarette;Clinical;Clinical Data;clinical research site;co-infection;Cognitive;cohort;Cohort Studies;Collection;comorbidity;Data;Data Analyses;data submission;Databases;Development;disability;Discipline;Disease;Disease Progression;Dropout;Elderly;Environment;Epigenetic Process;Etiology;Evaluation;Event;experience;falls;Feces;follow-up;Fostering;Fracture;frailty;Functional disorder;General Population;Genetic;Geography;Guidelines;Hair;health care availability;health disparity;Healthcare;Healthcare Systems;healthy aging;Hispanic Americans;HIV;HIV Infections;HIV Seronegativity;Hospitalization;Iatrogenesis;Immunologics;Immunology;Incidence;Infrastructure;innovation;Joints;Laboratories;Laboratory Study;Leadership;Los Angeles;Lung Diseases;Malignant Neoplasms;Measures;men;men who have sex with men;Mental Depression;Modality;Molecular;molecular marker;Morbidity - disease rate;mortality;Natural History;neurocognitive disorder;Neurologic;optimal treatments;Oral;Outcome;Participant;Pathogenesis;Persons;Pharmaceutical Preparations;Physical Function;Physiological;Play;Protocols documentation;psychologic;psychosocial;Psychosocial Factor;Publications;pulmonary function;recruit;repository;Research;Research Personnel;Respiratory Signs and Symptoms;Risk Factors;Role;Sleep Disorders;sleep quality;Specimen;Standardization;Students;success;The Multicenter AIDS Cohort Study;Tissues;treatment adherence;Treatment outcome;tumor;Urine;Viral reservoir;Women's Interagency HIV Study;working group

PROJECT_TITLE: Los Angeles CRS for the MACS/WIHS Combined Cohort Study


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This proposal seeks to provide career development support and infrastructure to produce the next generation of physician scientists who will lead research in Obstetrics and Gynecology.

PI_NAMEs: SANTORO, NANETTE F. (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: career;career development;Caring;Clinical;Clinical Research;Collaborations;Colorado;design;Development;Discipline of obstetrics;Doctor of Philosophy;Education;environmental enrichment for laboratory animals;experience;Funding;Generations;Goals;Gynecology;Institution;Left;Mentored Clinical Scientist Development Program;Mentors;Mentorship;next generation;Positioning Attribute;Productivity;Program Development;programs;Research;Research Personnel;Resources;Structure;success;Training Programs;Translational Research;translational research program;Women's Health;women's reproductive health

PROJECT_TITLE: Colorado Women's Reproductive Health Research Career Development Center


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: NARRATIVE Epigenetic mechanisms that govern imprinted domain regulation are complex. We have discovered a novel, nucleoporin mechanism of imprinted domain regulation, and having identified other factors involved in imprinting, we can now build upon this mechanism to understand how imprinted domain are regulated during early development. Data from this proposal will contribute to our understanding of how disruptions in imprinting can impact development and lead to imprinting disorders.

PI_NAMEs: MANN, MELLISSA RAE WIGLE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acetylation;Acetyltransferase;Actins;Address;Alleles;Antibodies;assisted reproduction;Assisted Reproductive Technology;blastocyst;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical Management;Complex;Data;Development;Diploidy;Disease;disease phenotype;DNA;DNA Methylation;DNMT3a;Embryo;Endoderm;Epigenetic Process;Fertilization;Fishes;fluorescence imaging;Genes;Genetic Transcription;Genome;Genomic Imprinting;Genomics;Growth;Hydatidiform Mole;imprint;Inherited;innovation;Investigation;Knowledge;Lysine;Maps;Medical;Metabolic;Methylation;Modeling;Mus;Neurologic;novel;Nuclear;Nuclear Matrix;nuclear pore complex protein p107;Nuclear Pore Complex Proteins;Patients;Phenotype;Physical assessment;Play;Pre-implantation Embryo Development;Process;Proteins;recruit;Regulation;Repression;Reproduction;RNA;RNA interference screen;Role;SMARCA5 gene;SMARCC2 gene;stem cells;TATA-Binding Protein Associated Factors;Teratoma;Testing;transcriptome sequencing;TRIM Gene;Untranslated RNA;Work;zygote

PROJECT_TITLE: Regulatory mechanisms governing imprinted domains during early development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Disability Research;Neurodegenerative;Social Determinants of Health

PHR: There is a dire need for physician scientists in geriatrics and aging research. This research training program is intended to increase the number and diversity of medical students who have interest and experience in research relevant to aging. The goal is to help develop the research workforce that is needed to meet the needs of our rapidly aging society.

PI_NAMEs: HAN, BENJAMIN HYUN (contact);LEE, ELLEN EUN-OK

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: age-related disease;Aging;aging related;Alzheimer's disease patient;Alzheimer's disease related dementia;American;California;Cardiovascular Diseases;career;Clinical;Clinical Research;clinical training;Communication;Country;design;Development;disability;disadvantaged background;Disease;Educational workshop;Eligibility Determination;epidemiology study;ethnic minority population;experience;Exposure to;Faculty;Funding;Geriatrics;Goals;hands on research;Impaired cognition;Institution;Learning Skill;Longterm Follow-up;Malignant Neoplasms;Manuscripts;Medical Students;meetings;Mental Depression;Mentors;Molecular;Molecular Biology;Oral;Peer Review;Physicians;posters;Prevention;Program Evaluation;programs;Publishing;racial minority;Records;recruit;Research;Research Personnel;Research Training;Residencies;response;Scientist;Societies;student training;Students;summer student;Supervision;Therapeutic Research;Training;Underrepresented Students;Universities;web site;Woman

PROJECT_TITLE: U C San Diego Medical Student Summer Aging Research Training


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE  Although many insights into the biology of aging have been gained, which underscore the multifactorial nature of this process and its complex regulation by interconnected genetic and environmental factors, we still know comparatively little about the mechanisms by which aging alters stem cell function and the organismal consequences of age-related stem cell exhaustion. The goal of this project is to develop a comprehensive model of maladapted stress-response mechanisms in aged hematopoietic stem cells (HSC) to identify actionable targets for rejuvenation interventions. In particular, we will leverage our identified hallmarks of an old HSC state to determine whether manipulating autophagy levels or mitigating the harmful effects of replication stress can restore the functional fitness of aged HSCs.

PI_NAMEs: PASSEGUE, EMMANUELLE  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Address;Affect;Age;age related;age-related disease;aged;Aging;aging process;aging related;Anabolism;Anemia;Animals;Automobile Driving;Autophagocytosis;Biogenesis;biological adaptation to stress;Biology;Biology of Aging;Blood;Blood Cells;bone aging;Bone Marrow;Brain;Bromodeoxyuridine;cdc Genes;Cell Cycle;Cell Cycle Regulation;Cell Respiration;Cell Separation;Cells;Cellular Metabolic Process;ChIP-seq;Chronic;comparative;Compensation;Complex;Dactinomycin;Deceleration;Defect;Dependence;design;Development;Disease;DNA Damage;DNA Maintenance;Elderly;Environmental Risk Factor;Epigenetic Process;Erythroid;exhaustion;experimental study;Exposure to;Fasting;feeding;fitness;Free Ribosome;functional decline;Functional disorder;functional improvement;functional restoration;Gene Expression Regulation;Genetic;Genomic Instability;Glucose;glucose uptake;Goals;hallmarks of aging;Helicase Gene;Hematologic Neoplasms;Hematopoiesis;hematopoietic hierarchy;hematopoietic stem cell aging;Hematopoietic stem cells;Hematopoietic System;Immune;immunosenescence;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;insight;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Like Growth Factor I;Intervention;Investigation;Label;Lead;Life;Link;Longevity;Lymphoid;Maintenance;Marrow;Mediating;Mediator;Metabolic;metabolomics;Modeling;Molecular;Mus;Nature;Nerve Degeneration;novel;Organism;Output;Pathway interactions;Physiologic pulse;Predisposition;Process;Production;progenitor;programs;Proteins;proteostasis loss;Recycling;regeneration potential;Regulation;Rejuvenation;replication stress;Reporter;Resistance;Resolution;response;Ribosomal DNA;Ribosomal Proteins;Ribosomes;Role;Secondary to;self-renewal;Signal Transduction;stem cell exhaustion;stem cell function;Stress;System;Systems Biology;Testing;Tissues;TP53 gene;Translations;Transplantation;Work

PROJECT_TITLE: Mechanisms of Hematopoietic Stem Cell and Blood aging

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Aging is a complex process that contributes to reduced function and increased disease risk in tissues throughout the body, including the blood system in which up to 15% of individuals aged 70 years or older are at risk for the development of hematologic disorders. As no methods currently exist to identify such at-risk individuals, there is a vital need to understand the mechanisms by which aging promotes hematologic disorders and their precursor conditions. This research is relevant to public health because it will provide important information that will impact the development of new methods and therapeutics to detect and mitigate risk of hematologic disorders during aging.

PI_NAMEs: TROWBRIDGE, JENNIFER JEAN (contact)

PROJECT_TERMS: Acceleration;Age;age acceleration;age related;aged;Aging;aging mechanism;aging related;Apoptosis;Automobile Driving;Biological;biomarker development;biomarker identification;Blood;Blood Cells;bone aging;Bone Marrow;cell type;Cells;Chronic;Clinical;Clonal Expansion;Complex;cytokine;Data;Detection;Development;disorder risk;DNA Damage;DNA Modification Methylases;DNMT3a;efficacy evaluation;Elderly;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Flow Cytometry;Goals;Growth Factor;Health;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;high risk;Human;human old age (65+);in vivo;Incidence;Individual;Inflammation;Inflammatory;innovation;MAP Kinase Gene;Methods;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myeloproliferative disease;next generation sequencing;novel;novel strategies;nucleophosmin;old mice;Outcome;Pathogenicity;Patients;Population;prevent;pro-aging;Process;progression risk;Proliferating;prophylactic;Public Health;Publishing;Ras/Raf;Research;Risk;risk mitigation;Role;Signal Transduction;Somatic Mutation;Survival Rate;System;Testing;Therapeutic;Time;Tissues;TNF gene;transcriptome sequencing;United States;Work

PROJECT_TITLE: Discovery of Aging-Associated Mechanisms Causing Expansion and Progression of Clonal Hematopoiesis of Indeterminant Potential (CHIP)

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ORG_DEPT: BIOPHYSICS

PHR: Project Narrative: Pathogenic microorganisms interact with their environment via membrane embedded transport proteins and signaling systems. Characterizing the mechanisms of these membrane proteins will reveal novel microbial vulnerabilities, and understanding their molecular architecture will pave the way for therapeutic drug design to exploit those vulnerabilities.

PI_NAMEs: STOCKBRIDGE, RANDY B. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Antibiotics;Architecture;Area;Biological Assay;biophysical analysis;Biophysics;Carrier Proteins;Catalogs;Chemicals;Coupled;Cryoelectron Microscopy;Crystallization;design;Development;Drug Design;Electrophysiology (science);Environment;Evolution;Fluorides;Future;Growth;guanidinium;host colonization;in vivo;inhibitor;insight;Ions;Lipids;Membrane;Membrane Proteins;Membrane Transport Proteins;Metabolism;Microbe;microbial;Microbial Biofilms;Microbial Physiology;microorganism;microorganism interaction;Molecular;Molecular Chaperones;Molecular Conformation;multidrug transport;novel;novel strategies;Pathogenicity;Physiological;Physiology;Potassium;Process;programs;protein-histidine kinase;receptor;Receptor Activation;reconstitution;Research;Research Activity;response;Signal Transduction;Signaling Protein;Site-Directed Mutagenesis;Structure;System;targeted agent;Technology;Therapeutic;Toxic Environmental Substances;Toxin;Vesicle;Virulence;Work;X-Ray Crystallography

PROJECT_TITLE: Structural and functional analysis of novel microbial membrane proteins


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Diseases associated with the aging brain, including Alzheimer's, Parkinson's, and ALS, which cause dementia and other symptoms, severely compromise the quality of life for those afflicted and those close to them. This Training Program seeks to provide young predoctoral and postdoctoral scientists the training they will need to become leaders in the field of aging and dementia research. By understanding the basic processes of brain aging, it will be possible to also understand what goes wrong in the devastating diseases that afflict so many.

PI_NAMEs: VASSAR, ROBERT J (contact);WEINTRAUB, SANDRA

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TITLE: Predoctoral and Postdoctoral Training Program in Aging and Dementia


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE: Cultivation of patient-oriented investigators is needed to generate significant improvement in patient outcomes in the field of addiction treatment. Dr. Sakai has a strong record of mentoring clinician investigators, especially physician scientists, and this career development award, with an emphasis on recruiting junior investigators from diverse backgrounds, will allow him to expand his research mentoring efforts.

PI_NAMEs: SAKAI, JOSEPH T (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;Acceleration;addiction;Affect;Aftercare;alcohol use disorder;Animals;Area;Award;Brain;career;career development;Clinical;Clinical Treatment;Clinical Trials;craving;Crossover Design;Cues;Dedications;Deep Brain Stimulation;Development Plans;Doctor of Philosophy;Evidence based treatment;FDA approved;Fellowship;Funding;Future;improved;Individual;innovation;Inpatients;interest;Intervention Studies;Investigation;K-Series Research Career Programs;Leadership;Left;Ligands;Literature;Location;Magnetic Resonance Imaging;Medicine;Mental Depression;Mentors;Mentorship;Meta-Analysis;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Methods;Midcareer Investigator Award in Patient-Oriented Research;Morbidity - disease rate;Neurobiology;neuroregulation;Nucleus Accumbens;Outcome;Outpatients;Pathway interactions;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Pilot Projects;pilot trial;Population Scientist Supplement (R25);Positioning Attribute;Postdoctoral Fellow;Prefrontal Cortex;preventable death;programs;Protocols documentation;Provider;Psychiatry;Randomized;recruit;Refractory;Research;Research Personnel;residential care facility;Rest;Rewards;Risk;Role;safety and feasibility;safety testing;Sample Size;Scientist;secondary outcome;Seizures;Serotonin Receptor 5-HT2A;Site;stimulant use;Substance Use Disorder;success;Techniques;Testing;Time;Training;Training Programs;Transcranial magnetic stimulation;Treatment outcome;Treatment Protocols;treatment research;Work

PROJECT_TITLE: Mentoring clinician scientists in patient-oriented substance use disorder research

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: WASHINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The research objective of this proposal is to develop ultra-soft, wireless, implantable, cardiac electro-metabolic mapping and pacing systems and apply them to chronically study cardiac electrophysiological and metabolic changes and their links during heart failure development, progression, and termination in unrestrained conscious animals at cell and tissue levels. Our research outcome will advance implantable cardiac devices for unprecedented bidirectional single-cell resolution electrical and metabolic mapping and stimulation of the heart, and identify complex disease mechanisms involved in pathophysiological conditions leading to lethal heart failure and its therapeutic treatment. Our results will greatly facilitate research into the basic operating principles of the heart and the therapeutic outcomes for treating various heart disease-related processes.

PI_NAMEs: LU, LUYAO  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acute;Address;American;Anesthesia procedures;Animal Experiments;Animal Model;Animals;bioelectronics;biophysical properties;Biophysics;Cardiac;cardiac device;cardiac implant;cardiac pacing;cardiac resynchronization therapy;Cardiology;Cardiovascular Physiology;Cell Culture Techniques;Cells;Chronic;Clinical;Color;Communities;Complex;computerized data processing;Conscious;Coronavirus;data acquisition;data communication;density;design;Development;Devices;Diabetes Mellitus;Diagnostic;Disadvantaged;Disease;electrical property;Electrophysiology (science);Energy harvesting;Energy Metabolism;experimental study;fabrication;Flavin-Adenine Dinucleotide;Functional disorder;Future;Genetic;Goals;graphical user interface;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart function;Heart Research;heart rhythm;Human;Imaging technology;Implant;implantable device;In Vitro;in vivo;Individual;Infection;innovation;Investigation;Label;Life;light emission;Link;Magnetic Resonance Spectroscopy;Malignant Neoplasms;Maps;Measurement;Measures;Mechanics;Metabolic;Metabolic Diseases;Metabolic dysfunction;Microelectrodes;Microfabrication;microsystems;miniaturize;Modality;Modeling;Modification;Morphologic artifacts;Motion;multimodality;Myocardial;Nicotinamide adenine dinucleotide;novel strategies;operation;optical imaging;Optics;Outcomes Research;Pathogenesis;Physiological;power harvesting;Process;Property;Qualifying;Quality of life;Radioactive Tracers;Rattus;Research;Resolution;Role;Scheme;Signal Pathway;skills;Statistical Data Interpretation;Surface;System;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapy outcome;Thoracic cavity structure;Time;Tissues;tool;wireless;wireless implant;Work

PROJECT_TITLE: Soft wireless multimodal cardiac implantable devices for long-term investigating heart failure pathogenesis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The proposed research is to develop novel inhibitors for RuvBL1-L2. These inhibitors can be potential therapeutic agents for triple negative breast cancer.

PI_NAMEs: LI, BINGBING ;XIAO, XIANGSHU  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: ataxia telangiectasia mutated protein;ATP phosphohydrolase;ATR gene;Binding;Binding Proteins;Biological;Biological Availability;brca gene;BRCA mutations;Breast Cancer Cell;Breast Cancer Model;cancer subtypes;Cell Line;Cell Physiology;Cell Survival;Cells;chemoproteomics;Complementary DNA;Complex;course development;Data;Defect;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;Drug Kinetics;druggable target;Epidermal Growth Factor Receptor;Estrogen Receptors;Evaluation;Excision;genome integrity;Genotoxic Stress;Goals;Government;homologous recombination;homologous recombination deficiency;Human;improved;in vitro activity;in vivo;inhibitor;Ionizing radiation;Lead;lead optimization;Malignant Breast Neoplasm;Malignant Neoplasms;Molecular;Mus;Mutate;new therapeutic target;Nonhomologous DNA End Joining;Normal Cell;novel;novel lead compound;novel therapeutics;Oncogenes;overexpression;p53-binding protein 1;Pathway interactions;patient derived xenograft model;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;Process;Progesterone Receptors;Prognosis;Property;protein complex;Proteins;Publishing;Reactive Oxygen Species;repaired;replication stress;Research;Resistance;resistance mechanism;response;Site;small molecule;small molecule inhibitor;Structure;Subgroup;Therapeutic;Therapeutic Agents;Toxic effect;TP53 gene;triple-negative invasive breast carcinoma;tumor;Xenograft procedure

PROJECT_TITLE: Small molecules targeting RuvBL complex for triple negative breast cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE HIV-1 capsid is a viable target for therapeutic interventions. In this project, we will perform a variety of experiments to elucidate how sequence variability in HIV-1 capsid affects the sensitivity to drugs, host factor utilization and cellular responses to viral DNA. New knowledge generated in this project will help improve future drug design and development.

PI_NAMEs: YAMASHITA, MASAHIRO  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;Anti-viral Agents;Binding;Biological Assay;Capsid;CD4 Positive T Lymphocytes;cell type;Cells;Charge;Clinic;Clinical;Coculture Techniques;combinatorial;Cone;Consequences of HIV;design;DNA;Drug Design;drug development;Drug Interactions;Drug resistance;drug resistance development;Equine Infectious Anemia Virus;Evolution;experimental study;fitness;Future;Genetic;genetic approach;high dimensionality;HIV-1;Immune;improved;inhibitor;Innate Immune Response;innate immune sensing;insight;Integration Host Factors;integration site;Kinetics;Knowledge;Laboratories;Lentivirus;Macrophage;Mediating;Molecular;Mutation;Mutation Analysis;mutation screening;novel;Nuclear;Nucleic Acids;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Play;Proteins;recruit;Resistance;Resistance profile;Resolution;response;Rest;Role;sensor;Shapes;Structure;System;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;transmission process;Variant;Viral;viral DNA;Viral Physiology;Virus Diseases;Virus Latency;Virus Replication

PROJECT_TITLE: Evolutionary potential of HIV-1 capsid: mechanisms and consequences

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: OMAHA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Displays of racism and discrimination and their impacts have intensified during the COVID-19 pandemic. By leveraging the nationally-representative bi-weekly and monthly Understanding America Study from March 2020 to June 2022 (38 survey waves) and intensive longitudinal data modeling, this mechanistic study aims to elucidate the nature and mechanisms of the association of discrimination with race and ethnicity inequalities in substance use and provide timely evidence to inform public health officials on how to mitigate the addiction crisis and protect vulnerable populations. .

PI_NAMEs: DAI, HONGYING DAISY (contact);LEVENTHAL, ADAM MATTHEW

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: addiction;Address;Adult;Alcohol consumption;Alcohols;Amplifiers;anti-Asian;anti-racism;Anxiety;anxiety symptoms;Asian population;Behavioral;binge drinking;Black Populations;Buffers;Cannabis;Characteristics;Cigarette;Climate;Coping Behavior;Coping Skills;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 vaccination;Crime;Data;data modeling;Data Reporting;Data Set;depressive symptoms;Discrimination;Disease;Drug usage;Economics;Electronic cigarette;Employment;Employment Status;Environment;ethnic difference;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;Event;Exercise;experience;Exposure to;follow-up;Food;Frequencies;Friends;hate crimes;health equity;Hispanic Populations;Household;Housing;Incidence;Internet;Intervention;killings;Life;Link;Measures;Mediating;Mediation;Mental Depression;Methods;minority communities;Modernization;multi-racial;multilevel analysis;Nature;Not Hispanic or Latino;Outcome;Outcome Study;pandemic impact;Patient Self-Report;people of color;perceived discrimination;Persons;Pharmaceutical Preparations;Police;Policy Maker;polysubstance use;Probability;prospective;Public Health;Race;racial difference;racial discrimination;racial disparity;racial minority;racial minority population;racial population;racism;recruit;Research;resilience;Risk Factors;Sampling;Science;secondary analysis;social;social determinants;social health determinants;substance use;Surveys;Techniques;Testing;theories;Time;Unemployment;United States;Vaccination;Volatilization;Vulnerable Populations

PROJECT_TITLE: Discrimination and Racial Inequalities in Drug Use in U.S. Adults: Associations and Mechanisms


NIH_SPENDING_CATS: Brain Disorders;Immunization;Infectious Diseases;Neurosciences;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: T cells in the brain can provide protection or cause disease and their control by specific neurons is not understood. This proposal will use sophisticated manipulation of specific neuronal signaling pathways and established models of brain T cell immunity and disease to address the interaction of these critical cell types.

PI_NAMEs: HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Area;Assessment tool;Attention;Brain;Brain Stem;brain tissue;Cause of Death;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular biology;Central Nervous System Diseases;Central Nervous System Infections;Cerebral Malaria;Clinical;Data;Dependovirus;designer receptors exclusively activated by designer drugs;disability;Disease;Dorsal;draining lymph node;drinking water;Etiology;experimental study;Exploratory/Developmental Grant;Fostering;Generations;Genetic;genetic technology;high reward;Homeostasis;Human;Immune;Immune system;Immune System Diseases;Immunity;Immunization;Immunologics;Immunology;Infection;Injections;Knowledge;Ligands;LoxP-flanked allele;Lymphocytic choriomeningitis virus;Maintenance;Mediating;Meningeal lymphatic system;Modeling;Mus;Nature;Nervous System;Nervous System Disorder;neuroimmunology;Neurons;neurotransmission;novel therapeutics;Operative Surgical Procedures;Organ;Outcome;Pain;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peripheral;Pharmaceutical Preparations;Process;Pruritus;response;Risk;Role;Serotonin;Signal Pathway;Signal Transduction;Specific qualifier value;Stimulus;Stress;System;T cell response;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Transgenic Organisms;Viral Encephalitis;Viral Pathogenesis;Virus

PROJECT_TITLE: Regulating Pathogen-induced Protective and Pathogenic CD8 T cells in the CNS

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Narrative Risk taking behavior in adolescence can be adaptive and help animals to disperse from ‘the nest.’ To better understand adolescent behavior we will study a brain region that regulates risk taking in a wild mouse species which has different timelines for leaving the nest that depend on season.

PI_NAMEs: WILBRECHT, LINDA E (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Behavior;adolescent brain development;Adolescent Development;Adolescent Risk Behavior;Age;Animals;Apical;Area;ARHGEF5 gene;Axon;Behavior;Behavioral;Body Weight decreased;Brain;Brain region;Breeding;C57BL/6 Mouse;Corpus striatum structure;Darkness;Data;density;Detection;Development;Dissociation;Dopamine;dopamine system;Elements;Ethology;Exploratory Behavior;Fiber;Goals;Human;Image;in vivo;Injections;Investigation;Label;Laboratories;Learning;Life;life history;Light;Measures;Modeling;Motivation;Mus;nanosensors;Nest Leaving;neural;Neurobiology;Neurons;novel;Nucleus Accumbens;Photometry;Photoperiod;Primates;programs;psychologic;Regulation;Rewards;Risk Taking;Rodent;season of birth;Seasons;sensor technology;Siblings;Site;Slice;Tail;Testing;Time;timeline;tool;Vertebral column;Virus;Weight Gain;Work

PROJECT_TITLE: Tail of the striatum and regulation of exploratory behavior in a wild mouse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-S(02)M]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Data Science;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This multidisciplinary two-year program is designed to provide short courses and hands-on workshops for brain network analysis. The goal is to engage undergraduate/graduate students in network neuroscience and train next-generation investigators with computational skillsets for solving real-world mental health problems.

PI_NAMEs: KIM, MINJEONG ;WU, GUORONG  (contact);ZHANG, ZHENGWU

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Adolescent;Affect;analytical tool;Biomedical Research;Biometry;Brain;Brain Diseases;Brain imaging;clinical application;cognitive development;Collection;Complex;computational platform;computer science;Computer software;computerized tools;connectome;connectome data;Data;Data Analyses;Data Collection;Data Science;Data Scientist;Data Set;Dedications;design;Development;Developmental Disabilities;Education;education planning;Education Projects;Educational workshop;Environment;Faculty;Goals;graduate student;Hour;Human;improved;Individual;insight;Knowledge;lectures;Life Cycle Stages;life span;lifestyle factors;longitudinal dataset;Machine Learning;Magnetic Resonance Imaging;Mathematics;Medical;medical schools;Medical Students;member;Mental Health;Mentors;Methodology;multidisciplinary;Nervous System Physiology;network architecture;neuroimaging;Neurologic Dysfunctions;neuropsychiatric disorder;Neurosciences;Neurosciences Research;next generation;North Carolina;novel;Online Systems;operation;Outcome;outreach;Outreach Research;Pathway Analysis;phenomenological models;Play;Postdoctoral Fellow;Process;programs;prospective;Psychiatry;Psychology;reconstruction;Recording of previous events;Reproducibility;Research;research faculty;Research Methodology;Research Personnel;response;Role;skills;Statistical Data Interpretation;statistics;Structure;Student recruitment;student training;Students;substance misuse;substance use;Substance Use Disorder;success;System;Technology;Time;tool;Training;undergraduate student;United States;Universities;user-friendly;Variant;Visualization;web site

PROJECT_TITLE: Promoting Collaborative Research on Human Connectome Analysis for Substance Use Disorders