NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Pediatric;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE This project establishes cancer research programs for high school and undergraduate students, as well as for middle and high school science teachers, to increase the pipeline of students currently underrepresented in the biomedical sciences who are interested in biomedical research careers. The long-term goal of this project is increase diversity in cancer-related and other biomedical research careers with the ultimate goal of eliminating health inequities.

PI_NAMEs: AYER, DONALD E (contact);MENDOZA, MICHELLE CHRISTINE;SUNEJA, GITA

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: 18 year old;Address;Age;Alaska Native;American;American Indian Tribe;American Indians;anti-cancer research;Awareness;Basic Science;Behavioral Research;Biomedical Research;cancer health disparity;Cancer Research Project;career;career networking;Cities;Clinical;Clinical Research;cohort;Collaborations;Communities;community building;Community Outreach;community setting;curriculum development;Education;Education Projects;Educational process of instructing;Ensure;Evaluation;Event;experience;Face;Family;Fostering;Goals;health inequalities;high school;high school program;High School Student;Hispanic;Home;Individual;Inequity;Influentials;innovation;Instruction;interest;Interest Group;International;junior high school;Laboratory Research;Latino;Latino Population;Learning;learning materials;Life;Malignant Neoplasms;Medical Students;member;Mentors;Middle School Student;Minority Groups;National Cancer Institute;Native Hawaiian or Other Pacific Islander;NCI-Designated Cancer Center;novel;outreach;outreach program;Pacific Islander;Participant;Persons;Physicians;Population;Population Sciences;Preparation;Prevention;Prevention education;Program Development;programs;recruit;Research;research and development;Research Training;role model;Science;science education;Science of genetics;science teacher;Scientist;screening;Screening for cancer;skills;Sodium Chloride;Specialist;Students;support network;teacher;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Universities;Utah;web site;Work

PROJECT_TITLE: Huntsman Cancer Institute PathMaker Programs for Cancer Research


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Osteoarthritis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because it is an unprecedented and fundamental step in determining the role of muscle quality in the development of poor rehabilitation outcomes following knee injury and surgery that commonly result in the development of posttraumatic knee osteoarthritis, a disease that affects millions of Americans each year. Therefore, this proposed research is relevant to the NIH mission pertaining to the development of successful, cost-effective interventions that reduce the risk of knee osteoarthritis development and the economic burden of the disease by producing high returns on public investment in medical research.

PI_NAMEs: PIETROSIMONE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Affect;American;anterior cruciate ligament injury;Area;articular cartilage;Biomechanics;burden of illness;Cartilage;Clinical;Clinical Trials;Contracts;cost effective intervention;Data;Development;Disease;Economic Burden;Evaluation;Exercise Therapy;Extensor;Functional disorder;Gait;Goals;Health;Imaging Techniques;Impairment;improved;Individual;Infrastructure;Injury;innovation;insight;Intervention;Investments;Joints;Knee;Knee Injuries;Knee Osteoarthritis;Limb structure;Link;long-term sequelae;Magnetic Resonance Imaging;Measurement;Measures;Medical Research;Medicine;Mission;Movement;Muscle;Muscle function;Muscular Atrophy;next generation;novel;Operative Surgical Procedures;Outcome;Parents;Pathway interactions;Patient Outcomes Assessments;Patients;Physical Function;Physical Performance;post-operative rehabilitation;Prognosis;Public Health;quadriceps muscle;Randomized;reconstruction;Rehabilitation Outcome;rehabilitation strategy;Rehabilitation therapy;Relaxation;Research;Risk;Risk Reduction;Role;Sample Size;Signal Transduction;success;Techniques;Testing;Time;Tissue imaging;Tissues;treatment strategy;Ultrasonography;United States National Institutes of Health;vibration;Work

PROJECT_TITLE: Quadriceps Muscle Quality: A Post-Injury Determinant of Knee Function and Health


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alcohol use disorder (AUD) is a significant public health problem, and current treatments do not address the impact of stress dysregulation and stress-induced craving and anxiety in AUD. The proposed research will address this problem and evaluate pregnenolone, which is a safe and well tolerated precursor of GABAergic and other neuroactive steroids, in a 12-week randomized controlled trial for improving alcohol use outcomes, other psychological and physical health functioning and patient related outcomes in those with AUD. Positive findings will support the use of pregnenolone to reduce heavy drinking outcomes and improve functioning among individuals with AUD.

PI_NAMEs: MILIVOJEVIC, VERICA  (contact);SINHA, RAJITA

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Address;Aftercare;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol relapse;alcohol use disorder;Alcoholism;alcoholism therapy;Alcohols;Anxiety;anxiety symptoms;Biological Markers;Biology;Characteristics;Chemosensitization;Chronic;chronic alcohol ingestion;clinical efficacy;Clinical Research;Cognitive;craving;Cues;Data;depressive symptoms;Development;Dose;Double-Blind Method;drinking;efficacious treatment;efficacy evaluation;efficacy study;efficacy testing;executive function;FDA approved;flexibility;follow-up;Functional disorder;functional improvement;gamma-Aminobutyric Acid;Glucuronides;Health Care Costs;Heavy Drinking;Human;hypothalamic-pituitary-adrenal axis;improved;Individual;innovation;Laboratories;men;Mental Depression;Mental disorders;Mental Health;Neurosecretory Systems;neurosteroids;novel;Outcome;Pathway interactions;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase II Clinical Trials;physical conditioning;Placebo Control;Placebos;Play;Prefrontal Cortex;Pregnenolone;Prevalence;primary outcome;Public Health;Randomized;Randomized, Controlled Trials;receptor;Recording of previous events;reduced alcohol use;Regulation;Relapse;Reporting;Research;Role;Safety;safety assessment;secondary outcome;Self Assessment;Self-control as a personality trait;Severities;sex;Stress;stress reduction;Surgeon;Testing;Time;Trauma;treatment duration;treatment effect;Up-Regulation;Woman

PROJECT_TITLE: Pregnenolone for the Treatment of Alcohol Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Clinical genetic testing is becoming increasingly common, particularly among patients with cardiovascular disease. Much of our understanding of genetic disorders was obtained prior to the wide use of genetic testing in clinical practice, creating a biased view of the symptoms and outcomes that occur among patients that carry disease-associated mutations. This project seeks to use computational modeling and large electronic health record datasets to learn more detailed information about the consequences of rare mutations in genes linked to congenital disorders with severe cardiovascular symptoms.

PI_NAMEs: BLAIR, DAVID RANDALL (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Academic skills;Affect;All of Us Research Program;Award;Back;Benign;biobank;Biochemical;Biological Assay;biomedical data science;Calibration;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;career development;Caring;Case Series;Childhood;Classification;Clinical;Clinical Data;clinical diagnostics;clinical effect;clinical practice;Cohort Studies;Complex;Computer Models;Congenital Disorders;Data;Data Analyses;Data Set;Databases;design;Development;Diagnosis;Diagnostic;Diagnostic tests;Disease;disease heterogeneity;disorder risk;DNA Sequence Alteration;Electronic Health Record;Ensure;Funding Opportunities;Future;Gene Frequency;Genes;Genetic;Genetic Diseases;genetic testing;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genomic data;Genotype;Goals;Grant;health care quality;Hereditary hemorrhagic telangiectasia;Human;Human Genetics;improved;in silico;Individual;ineffective therapies;insight;Investigation;Knowledge;Laboratories;Learning;Link;Literature;loss of function;Marfan Syndrome;Measurement;Measures;Medical;Medical Genetics;Medical History;Mendelian disorder;Mentors;Methods;model building;Modeling;Molecular;multiple datasets;Mutation;Onset of illness;Outcome;Pathogenicity;Patients;Persons;Phenotype;Physicians;Physiological;Population;predictive modeling;Prognosis;programs;Property;protein structure;rare variant;Reproducibility;Research;research clinical testing;Research Proposals;Science of genetics;Scientist;Sea;Severities;Severity of illness;Specific qualifier value;Symptoms;Syndrome;Technical Expertise;Technology;Testing;tool;Training;trait;Transcript;Uncertainty;Validation;Variant;variant of unknown significance;wasting;Writing

PROJECT_TITLE: Investigating the Genotype-Phenotype Relationships that Underlie Congenital Disorders with Cardiovascular Symptoms through Population-scale Analyses


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Cervical Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project seeks to address the cervical cancer health disparities experienced by American Indian/Alaska Native women by comprehensively assessing the utilization and applicability of available cervical cancer prevention tools such as HPV vaccination, pap smear compliance, and high-risk HPV types that play can impact all levels of clinical care.

PI_NAMEs: BRUEGL, AMANDA S (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adopted;Age;Alaska Native;Alaska Native population;Alaska Native Women;American Indian Population;American Indian Women;American Indians;Area;Australia;Award;Biopsy;burden of illness;cancer health disparity;career;Centers for Disease Control and Prevention (U.S.);Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Clinical;clinical care;clinical research site;Colposcopy;Communities;Country;Coupled;Cross-Sectional Studies;Data;data registry;Death Rate;Development;Diagnosis;Discipline of obstetrics;Disease;Disparity;disparity elimination;Dysplasia;Early treatment;Educational Curriculum;Epidemiology;Exhibits;experience;Female;Focus Groups;follow-up;Foundations;Gender;Goals;Gynecology;Health;health disparity;Health Personnel;Heterogeneity;High Prevalence;high risk;HPV-High Risk;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immunization Programs;Incidence;Intervention;K-Series Research Career Programs;Learning;Lesion;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Mentors;Mentorship;Minority;Mission;mortality;National Cancer Institute;National Health and Nutrition Examination Survey;Not Hispanic or Latino;Oregon;Pacific Northwest;Pap smear;Patients;Play;Population;Prevalence;prevent;Prevention;Primary Prevention;Procedures;professor;Public Health;Publishing;Recommendation;Reproducibility;Research;reservation-based;Resources;Risk Factors;Role;Science;Scientist;screening;Smoking;Socioeconomic Status;Study models;surveillance strategy;Teacher Professional Development;Time;Time trend;tool;Training;trend;tribal organization;Tribes;Universities;Urban Population;Vaccinated;Vaccination;vaccine acceptance;vaccine efficacy;Vision;Visual;White Women;Woman;Wood material;Youth

PROJECT_TITLE: Utilization of cervical cancer prevention tools and role of high-risk HPV type in the persistent cervical cancer disparities experienced by American Indian/Alaska Native women

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project narrative Despite the success of cochlear implants, devices surgically placed in the inner ears of patients with severe hearing loss, there remains substantial variability in the overall speech perception outcomes for the children and adults who receive them. The main goals of this project are: i) to improve our understanding of how cochlear implants affect the developing auditory system, ii) apply that knowledge to test new methods for programming children and adults, and iii) to study how long it takes listeners to adapt to new cochlear implant programs over the short- and long-term. The results will improve our understanding of how the deafened auditory system develops with cochlear implant stimulation and advance clinical practice to improve hearing outcomes in cochlear implant listeners.

PI_NAMEs: ARENBERG, JULIE G (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 17 year old;2 year old;Acclimatization;Acoustic Nerve;Action Potentials;Adult;Affect;Age;age group;Auditory;Auditory system;Behavioral;Child;Chronic;Clinical;clinical care;clinical decision-making;clinical practice;Cochlea;Cochlear Implants;Complex;critical period;Crossover Design;Cues;Data;deaf;density;Detection;Development;developmental plasticity;Devices;Effectiveness;electric field;Electric Stimulation;Electrodes;Electrophysiology (science);Environment;experience;experimental study;functional improvement;Goals;Grant;Guidelines;Hearing;hearing impairment;Hour;Implant;Implanted Electrodes;improved;Individual;innovation;Knowledge;Labyrinth;life span;Manufacturer;Measures;Methods;neural prosthesis;Neurons;Neurosciences;new technology;Operative Surgical Procedures;Outcome;Participant;Patients;Performance;Peripheral;Physiologic pulse;Physiological;Population;programs;Progress Reports;Protocols documentation;Psychophysics;Publications;Research;Resolution;Signal Transduction;sound;Speech Perception;speech recognition;Stimulus;success;Testing;theories;Time;Work

PROJECT_TITLE: Perceptual implications of cochlear implant electrode-neuron interfaces


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Drug Abuse (NIDA only);Gene Therapy;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Substance Misuse;Vaccine Related

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE HIV-1 antiretroviral therapy (ART) has been transformative, but comes with side effects, stigma, and the need for daily self-administration. HIV-1 broadly neutralizing antibodies (bNAbs) could replace these therapies, but current approaches for their delivery are inadequate. We propose to convert primay B cells into efficient and adaptive bNAb-delivery vehicles that can control an established HIV infection.

PI_NAMEs: FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acceleration;Affinity;Anatomy;Animals;Antibodies;antibody transfer;Antigens;antiretroviral therapy;Apical;arm;Autoantigens;B cell repertoire;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Biological Availability;Blood - brain barrier anatomy;Brain;Catabolism;Cells;Cerebrospinal Fluid;cerebrovascular;chimeric antigen receptor;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cost;delivery vehicle;design;Development;Effector Cell;emerging virus;Endothelial Cells;Engineering;Engraftment;Epitopes;Excision;Exclusion;Face;Fc domain;Fc Receptor;fitness;Gene Transduction Agent;Genes;Half-Life;HIV;HIV Infections;HIV-1;IgG1;Immune;Immune Sera;Immune system;Immunization;immunogenic;immunogenicity;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunologics;improved;in vivo;Individual;individual response;Infection;Infection Control;Infusion procedures;inhibiting antibody;Injections;Interruption;Intervention;Left;Light;Lymphoid Tissue;Macaca;Macaca fascicularis;Macaca mulatta;manufacturing cost;Methods;Modification;Monitor;Mus;Mutation;neutralizing antibody;Orthologous Gene;pathogen;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Primates;Proliferating;Proteins;Protocols documentation;Proviruses;repaired;Replacement Therapy;response;Route;Self Administration;Series;side effect;simian human immunodeficiency virus;Site;small molecule;social stigma;Structure;System;T cell response;Techniques;Technology;Testing;TFRC gene;Time;transcytosis;uptake;Vaccinated;Vaccination;Variant;Viral;Viremia;Virus;Work

PROJECT_TITLE: Engineering CAR-B cells for an HIV-1 functional cure


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: NARRATIVE This project addresses how heme, an essential iron containing nutrient, cofactor, and signaling molecule, serves as an inter-organellar and inter-organ signal that regulates lifespan in cells and animals. Understanding the molecular processes that govern organismal and cellular aging will be critical for new therapies that can help extend lifespan and healthspan and mitigate aging related diseases.

PI_NAMEs: HAMZA, IQBAL ;REDDI, AMIT RAM (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;age-related disease;Aging;aging related disease;Animal Model;Animals;Binding;Biochemical;Biochemical Genetics;Biological;Biological Availability;Biophysics;Caenorhabditis elegans;Catalysis;Cell Aging;Cell model;Cells;Cellular biology;Chelating Agents;cofactor;Collaborations;Communication;cytotoxic;Data;Dietary Iron;Dissociation;Electron Transport;Endowment;Enterocytes;Exhibits;extend lifespan;extracellular;Funding;Gases;Gene Deletion;Genes;Genetic;genetic approach;hallmarks of aging;healthspan;Heme;Heme Iron;Homeostasis;Hydrophobicity;inhibitor;Ion Channel;Iron;Laboratories;life span;Lipids;Location;Longevity;Mass Spectrum Analysis;Mediating;Membrane;Metabolic;Microbe;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Molecular Genetics;mutant;Neurons;novel;novel therapeutics;Nucleic Acids;Nutrient;Organ;Organelles;Oxidative Stress;Pathway interactions;Phosphotransferases;Process;Property;Proteins;Proteomics;proteostasis;Publishing;receptor;Regulation;Respiration;response;RNA Interference;Role;Saccharomyces cerevisiae;sensor;Signal Transduction;Signaling Molecule;Site;Source;Testing;Therapeutic Intervention;Tissues;trafficking;transcription factor;Transition Elements;transmission process;Yeasts

PROJECT_TITLE: Lifespan Regulation by Inter-Organellar Heme Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Lung

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Neutrophilic asthma is a subtype of severe asthma, which is poorly understood and treated. This proposal examines molecular pathways that connect host derived extracellular DNA to to neutrophilic inflammation. It identifies novel therapeutic targets and conducts preclinical studies that will pave the way to the development of novel therapies for neutrophilic asthma.

PI_NAMEs: ALAM, RAFEUL  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abbreviations;Adaptor Signaling Protein;Adjuvant;Agreement;airway hyperresponsiveness;airway inflammation;Allergens;Alternaria;Aluminum Hydroxide;Alveolar Macrophages;Anti-Inflammatory Agents;Asthma;asthma exacerbation;asthma model;asthmatic patient;Biopsy Specimen;Blood donor;bronchial epithelium;Bronchoalveolar Lavage;Cadaver;Cells;chemokine;Confocal Microscopy;cytokine;Data;Deoxyribonucleases;Development;disorder control;DNA;effective therapy;eosinophilic inflammation;Epithelial Cells;Excision;extracellular;Extracellular Fluid;Extrinsic asthma;Family;Fc Receptor;Flow Cytometry;Generations;Human;human DNA;Immunofluorescence Immunologic;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;Interferon Activation;Interferon Type I;Interferon Type II;Interferons;Interleukin-10;interleukin-10 receptor;Interleukin-2;Knockout Mice;Lipofectamine;Lung;Macrophage;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;Nasal Lavage Fluid;neutrophil;new therapeutic target;novel;novel therapeutics;Nucleosomes;Orthologous Gene;Outcome;Pathologic Processes;Pathology;Pathway interactions;patient subsets;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;preclinical study;programs;Proteins;Refractory;Rhinovirus;Role;sensor;Serum;Signal Transduction;Sputum;Stains;Stimulator of Interferon Genes;STING1 gene;targeted treatment;Therapeutic;therapeutic evaluation;tissue resident memory T cell;TNF gene;TNFSF4 gene;transcriptomics;Virus

PROJECT_TITLE: DNA induction of neutrophilic asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Plugging & Pulling-in: tuning peptides for TolC to overcome antibiotic resistance Narrative Antibiotic resistance is an increasingly dire global health challenge. Antibiotic efflux pumps push antibiotics out of bacterial cells so that antibiotics cannot reach their targets. We plan to identify features of peptides that bind efflux pumps to either 1) plug the pumps to potentiate antibiotics or 2) pull through the pumps for drug delivery.

PI_NAMEs: SLUSKY, JOANNA SG (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Affinity;alpha helix;Amino Acids;Aminoglycosides;antibiotic efflux;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Architecture;Bacteria;Bacterial Translocation;beta barrel;beta-Lactams;Binding;Binding Proteins;Biological Assay;Calorimetry;Cells;Cessation of life;Chemosensitization;Chloramphenicol;Clinical;colicin;combat;Data Set;Databases;Development;Drug Delivery Systems;E coli tolC protein;Effectiveness;efflux pump;Escherichia coli;Evolution;experimental study;fighting;Fluorescence;Fluoroquinolones;Frequencies;Geometry;global health;Goals;Gram-Negative Bacteria;HIV/AIDS;improved;Infection;interest;Knowledge;Length;Libraries;Macrolides;Malaria;Measures;Membrane;Membrane Proteins;novel therapeutics;Outcome;overexpression;Pattern;Peptide Library;Peptides;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;Predisposition;Process;Protein Import;protein protein interaction;Protein translocation;Proteins;prototype;Pump;quaternary ammonium compound;Research;Resistance;single molecule;Structure;success;Superbug;Surface;System;Tetracyclines;Time;Titrations;tool;Triclosan;Visualization;Work;Yeasts

PROJECT_TITLE: Plugging & Pulling-in: tuning peptides for ToIC to overcome anitbiotic resistance

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Methamphetamine;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative Social context and resulting social choices are key features of health whose neural circuitry are not well understood. We will combine systems neuroscience tools with new machine learning approaches to interrogate anterior cingulate projections to the amygdala and nucleus accumbens during a novel rodent social choice paradigm. Given MDMA's impact on social reward, we will also test the impact of MDMA paired social exposure on social choice during our paradigm.

PI_NAMEs: ALLSOP, AZA STEPHEN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Absence of pain sensation;Acute;Algorithms;Amygdaloid structure;Animals;Anterior;Bayesian Modeling;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;behavioral pharmacology;career;cingulate cortex;Clinical;clinically significant;Computer Models;Computing Methodologies;Data;Decision Making;deep learning;deep learning model;Dimensions;ecstasy;Empathy;Environment;experience;experimental study;FDA approved;Feeling;Goals;Health;Human;Impairment;individual variation;innovation;Intervention;Joints;K-Series Research Career Programs;Machine Learning;Measures;Mediator;Mentors;Methamphetamine;Methods;Mus;neural;neural circuit;neural model;neuromechanism;neuronal circuitry;Neurons;neuropsychiatry;Neurosciences;neurotransmission;Nonlinear Dynamics;novel;Nucleus Accumbens;optogenetics;Pain;Partner in relationship;Pharmaceutical Preparations;pharmacologic;Post-Traumatic Stress Disorders;preference;Primates;Research;Research Personnel;response;Rewards;Rodent;Role;skills;social;social anxiety;Social Behavior;social bias;Social Change;social cognition;Social Environment;Social Interaction;social learning;Social Processes;social relationships;Space Models;Statistical Models;Stimulus;Stress;Structure;Subgroup;System;Testing;tool;Training;unsupervised clustering;vector

PROJECT_TITLE: Decoding ensemble dynamics from cortico-amygdalar circuits during social choice

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Bacteria communicate using a process called quorum sensing to cooperatively change expression of genes required for pathogenesis, including secretion of toxins and biofilm formation. My lab studies the regulation of quorum sensing genes in marine Vibrio bacteria that are human pathogens. We will determine how quorum sensing signals are integrated together with environmental signals to control gene expression required for pathogenesis and development.

PI_NAMEs: VAN KESSEL, JULIA C. (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: antimicrobial;Bacteria;Behavior;Behavior Control;Biochemical;Biological Models;Bioluminescence;Biophysics;Cell Culture Techniques;Cells;Chromosome Structures;Communication;comparative;comparative genomics;Control Groups;Data;design;Development;Disease;Environment;experimental study;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;human pathogen;Infection;inhibitor;intercellular communication;Link;marine;Microbial Biofilms;Microfluidics;Modeling;Motility;Nutrient availability;Output;pathogen;Pathogenesis;Pathway interactions;Population;Population Density;Process;Production;programs;protein function;Proteins;quorum sensing;Regulation;Research;response;Signal Transduction;Structure;System;Therapeutic;tool;Toxin;transcription factor;Transcriptional Regulation;Variant;Vibrio;Vibrio Infections;Virulence;virulence gene;Work

PROJECT_TITLE: Quorum sensing regulation of bacterial development

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Narrative Building on research regarding the Tripartite Integration Model of Social Influence (TIMSI), Native American culture, and integrative identity, we propose to conduct a longitudinal quasi-experimental study to assess intervention impacts on Native biomedical scholar research career development. Specifically, we propose to use a prospective propensity score matched longitudinal design to compare the short-, medium-, and long-term outcomes of three groups of emerging Native biomedical scholars. This proposed study will advance research in this area by assessing how and when Native scholars integrate into their professional communities and what interventions contribute towards that integration.

PI_NAMEs: ESTRADA, MICA BETH (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: African American;Alaska Native;American Indians;Area;Behavioral;Biomedical Research;career;career development;Censuses;commune;Communities;Community Actions;comparison group;Control Groups;cost;cost effective;Dedications;design;Development;Discipline;Education;efficacy testing;Elements;Engineering;Enrollment;evidence base;Faculty;Fostering;Future;Graduate Enrollment;graduate student;higher education;improved;Individual;interest;Intervention;intervention effect;Interview;Knowledge;Latinx;Learning;Light;Lighting;longitudinal design;Longitudinal Studies;Measures;Mediating;member;Mentors;Mentorship;Modeling;Native Americans;Native Hawaiian;Native-Born;online community;online intervention;Outcome;parenting intervention;Participant;Pathway interactions;Perception;Persons;Population;programs;prospective;psychosocial;Psychosocial Factor;Publications;Quasi-experiment;Research;Research Project Grants;role model;scale up;Science;science teacher;Scientist;social;social influence;Societies;STEM career;STEM field;Students;success;Technology;Testing;therapy development;Time;Training Programs;treatment comparison;treatment group;undergraduate student;Universities

PROJECT_TITLE: Scaling Up Culturally Affirming Pathways to Biomedical Faculty Careers for Native Scholars

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The Emory BIRCWH Program will provide career development training and support for early career investigators interested in women’s health research and sex/gender science, with a specific focus on training racial/ethnic minority candidates. The program will oversee a formal curriculum that includes didactic training and one-on-one mentoring by interdisciplinary senior investigators. The ultimate goal is to develop the next generation of leaders in women’s health research.

PI_NAMEs: OFOTOKUN, IGHOVWERHA  (contact);STERK, CLAIRE E

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: career;career development;Clinical Research;cohort;Communities;design;Education;experience;Faculty;fundamental research;Funding;gender difference;graduate school;Individual;Infrastructure;infrastructure development;innovation;Institution;interest;Leadership;Master of Science;mentoring community;Mentors;Methodology;Mission;multidisciplinary;next generation;Paper;Peer Review;Program Development;programs;Publishing;recruit;Research;Research Training;Science;sex;Sex Differences;skill acquisition;Structure;tool;Training;Training Programs;United States National Institutes of Health;Universities;Women's Health

PROJECT_TITLE: Emory University BIRCWH Program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE  The proposed research aims to discover critical neural correlates resulting from repeated excessive alcohol drinking that may progressively lead to the allostatic state. We focus specifically on neuronal plasticity associated with the development of maladaptive affective behaviors caused by repeated binge drinking. We will determine how dysfunctions in valence coding amygdala neurons and projections from anterior insular cortex to these neurons contribute these behaviors, and we seek to identify circuit-based novel targets for more effective treatment of AUD.

PI_NAMEs: SUH, JUNGHYUP  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Affect;Affective;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Animals;Anterior;Anxiety;anxiety-like behavior;approach behavior;Area;associated symptom;Behavior;Behavioral;Behavioral Assay;behavioral plasticity;binge drinking;Brain;cell type;Clinical;Code;Consummatory Behavior;Darkness;Data;Desire for food;Development;disease model;drinking;effective therapy;Electrophysiology (science);Etiology;experience;experimental study;Functional disorder;Goals;in vivo calcium imaging;Insula of Reil;Interoception;Knowledge;Lead;Measurement;Mediating;Mental Depression;Modeling;Molecular;Motivation;Mus;Negative Valence;neural;neural circuit;neural correlate;neuroimaging;Neuronal Plasticity;Neurons;novel;optogenetics;Outcome;Pathologic;Patients;Population;Positive Valence;preclinical study;Procedures;Recording of previous events;Research;Research Proposals;Risk Factors;Role;Self Administration;Stimulus;Structure;Symptoms;Synapses;Synaptic plasticity;Transgenic Mice;Translational Research;Work

PROJECT_TITLE: Insula-amygdala circuits in alcohol abuse

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The combination of Second Harmonic Generation microscopy and Surface Enhanced Mid InfraRed Spectral Imaging will provide a comprehensive characterization of extracellular matrix changes in human carcinomas. This knowledge will provide new insight into cancer etiology and may form the basis for enhanced diagnostic/prognostic approaches. The method will be applicable to numerous carcinomas.

PI_NAMEs: CAMPAGNOLA, PAUL J (contact);YESILKOY, FILIZ

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Architecture;Area;Biochemical;Biochemistry;Biological;Biomimetics;Breast;Cancer Biology;Cancer Etiology;carcinogenesis;Carcinoma;Chemicals;Classification;Collagen;Collagen Fiber;computerized data processing;Coupling;crosslink;Cytoskeleton;Data;Diagnostic;Dimensions;Disease;Disease Progression;DNA Sequence Alteration;Etiology;Extracellular Matrix;Fiber;Fibronectins;Gel;Generations;glycosylation;Heterogeneity;Human;Image;image reconstruction;imaging approach;imaging modality;imaging platform;In Vitro;insight;Knowledge;Label;Laminin;Libraries;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;Microscopy;migration;Modality;Modeling;Modification;Molecular;Molecular Profiling;Morphology;Multimodal Imaging;multimodality;nanophotonic;Neoplasm Metastasis;Normal tissue morphology;novel;Optics;ovarian neoplasm;Ovary;Pancreas;performance based measurement;Phosphorylation;Post-Translational Protein Processing;Prognosis;prognostic;Protein Isoforms;Resolution;Role;second harmonic;second harmonic generation imaging;self assembly;Serous;Shapes;Specimen;spectrograph;Spectrum Analysis;Speed;Structure;Surface;Tissue imaging;Tissue Sample;Tissues;treatment response;tumor;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches.


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), is a common life- threatening disease currently with no effective pharmacological interventions; ALI/ARDS is caused by the over- activation of macrophages and infiltration of neutrophils in the inflammed lungs, and past failures of investigative interventional therapies are in part owing to their inability to resolve the overwhelming acute pulmonary inflammation. Here, we propose to engineer synergistic cytokine-coated macrophage-based immunomodulatory therapy that can efficiently target the injuried lungs, program the pulmonary macrophages and neutrophils toward anti-inflammatory status, and eventually resolve the acute pulmory inflammation. If successful, this study would lay the foundation to develop novel cellualr immunotherapies for targeted immunomodulation in ALI/ARDS which can potentially revolutionize how ALI/ARDS is pharmacologically treated.

PI_NAMEs: ZHAO, ZONGMIN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Alveolar Macrophages;Animals;Anti-Inflammatory Agents;Area;Bacterial Infections;Biocompatible Materials;Biodistribution;Biological Assay;Cause of Death;Cell Therapy;Cells;Cellular immunotherapy;Clinical Research;combinatorial;COVID-19;COVID-19 mortality;COVID-19 patient;cytokine;cytokine release syndrome;Data;Death Rate;Dependence;design;Diagnosis;Disease;Dose;Drug Kinetics;effective therapy;efficacy evaluation;efficacy study;Engineering;Environment;Failure;follow-up;Foundations;Goals;Health;Health Care Costs;Hospitalization;IL4 gene;Immune;immunomodulatory strategy;immunomodulatory therapies;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;innovation;Interleukin-10;Interleukin-4;Intervention;Intervention Studies;Investigation;Life;Lung;lung injury;Macrophage;Macrophage Activation;Measures;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;nano;neutrophil;Neutrophil Infiltration;novel;Onset of illness;pandemic disease;pathogen;Pathway interactions;Patients;Performance;pharmacologic;Pharmacotherapy;Phase;Phenotype;Pneumonia;Population;pre-clinical;prevent;Process;programs;pulmonary function;Pulmonary Inflammation;Research Personnel;Resolution;Sepsis;Site;Standardization;Structure of parenchyma of lung;Supportive care;Symptoms;System;targeted treatment;Therapeutic;Therapeutic Intervention;Time;Tissues;trafficking;Transfusion;Trauma;Treatment Efficacy;United States;ventilation;Ventilator;Viral

PROJECT_TITLE: Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The proposed study focuses on using the ADAPT-ITT framework to adapt material from existing career readiness interventions (Work2Prevent, tailored to young SMM and trans women of color at-risk for HIV infection, and iFOUR, tailored to older people living with HIV, regardless of race) to the needs of young Black SMM (YBSMM), ages 18-29, living with HIV. Given that economic challenges have been demonstrated to limit YBSMM’s engagement in HIV treatment, this intervention has the potential to support HIV-positive YBSMM in improving their economic conditions and associated HIV treatment outcomes. Further, the study uses implementation science methods to understand the context of implementation to prepare for efficient and cost- effective delivery in community-based organizations.

PI_NAMEs: MOTLEY, DARNELL N (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;aged;AIDS prevention;arm;Attention;Award;barrier to care;Black race;career preparation;Caring;Characteristics;Climate;Communities;community organizations;computerized;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost effective;Data;Development;Economic Conditions;Economics;Elements;Employee;Employment;Enrollment;Ensure;epidemic preparedness;experience;Feedback;Financial Support;Focus Groups;follow up assessment;follow-up;Goals;HIV;HIV Infections;HIV Seropositivity;Homelessness;Hour;implementation context;implementation intervention;implementation outcomes;Implementation readiness;implementation science;improved;Individual;Informal Social Control;innovation;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Language;Manuals;Measures;medication compliance;member;men employment;Mentorship;Methods;Minority;Minority Groups;Modeling;Occupations;Older Population;Outcome;Outcome Study;Outcomes Research;Persons;Phase;Pilot Projects;pilot trial;Population;population health;Poverty;prevention service;Procedures;Process;programs;Protocols documentation;Qualitative Research;Race;racial discrimination;Randomized, Controlled Trials;Readability;Reading;recruit;Research;Research Personnel;Research Project Grants;Risk;Role;Sampling;secondary outcome;Self Efficacy;Series;sexual minority men;sixth grade;skills;success;Supported Employment;Surveys;Testing;therapy development;transgender women;Treatment outcome;treatment services;Unemployment;United States National Institutes of Health;Update;uptake;Viral;Visit;women of color;Work;Youth

PROJECT_TITLE: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: This program is designed to provide intensive training in research relevant to patients requiring anesthesia, critical care, and/or pain intervention. Provision of the next generation of physician- scientists will serve to improve medical care based on acquisition of scientific evidence and better understanding of relevant disease states.

PI_NAMEs: TREGGIARI, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Anesthesiology;Research;Training

PROJECT_TITLE: Integrated Training in Anesthesiology Research


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative The overall goal of this research is to better predict drug efficacy and safety in humans. New in vitro methods and in vivo data will be used to develop new mathematical models that incorporate membrane partitioning, permeability-limited diffusion, blood flow, active transport, and metabolism in order to better predict intracellular and extracellular drug concentration-time profiles.

PI_NAMEs: KORZEKWA, KENNETH RAY (contact);NAGAR, SWATI

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Acids;Active Biological Transport;Adipocytes;aqueous;Artificial Membranes;Automobile Driving;base;Binding;Blood flow;Caco-2 Cells;Cell Membrane Permeability;Cells;Charge;Convection;cost effective;Data;Data Set;Differential Equation;Diffusion;Discontinuous Capillary;Dose;drug clearance;drug development;drug disposition;drug distribution;drug efficacy;Drug Kinetics;drug metabolism;Drug toxicity;Endothelium;Environment;Enzymes;Equation;Erythrocytes;Excipients;Exhibits;experimental study;extracellular;feeding;Funding;Glycocalyx;Goals;Head;Hepatocyte;House mice;Human;Image;improved;In Vitro;in vivo;Intestines;Kinetics;Knock-out;Literature;Liver;mathematical methods;mathematical model;Measures;medication safety;Membrane;Metabolism;Methods;Microdialysis;Microfluidics;Microsomes;Modeling;Mus;novel;Oral;Organ;Particle Size;Perfusion;Permeability;Pharmaceutical Preparations;pharmacokinetic model;physiologically based pharmacokinetics;Pinocytosis;Plasma;polar environment;Polysorbate 80;predictive modeling;predictive tools;Process;Rattus;Reaction;Research;Rodent;Special Population;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Techniques;Testing;Time;Tissues;Tube;uptake;Work

PROJECT_TITLE: Predicting Intracellular Drug Concentrations In The Presence Of Transporters

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ROCKVILLE

ORG_NAME: MESO SCALE DIAGNOSTICS, LLC

ORG_STATE: MD

PHR: We propose an industrial-academic collaboration to characterize islet-derived extracellular vesicles in order to improve detection, monitoring, classification, and treatment of type 1 diabetes. We will use our recently developed and validated technology to identify specific combinations of surface markers on extracellular vesicles. This will enable us not only to measure relative concentrations of subgroups we suspect to be clinically relevant, but also to specifically isolate these subgroups and to measure their content.

PI_NAMEs: ROUTENBERG, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Affect;Alpha Cell;assay development;Autoimmune;Beta Cell;Biological Assay;Biological Markers;Biology;Blood;Cell Culture Techniques;Cell Line;Cell model;cell type;Cells;Cellular Stress;Classification;Clinical;clinically relevant;cohort;Collaborations;combinatorial;Complex;Confidential Information;Detection;Development;Diagnosis;Diagnostic;Disease;disorder risk;Early identification;Environment;Evaluation;Event;Exocrine pancreas;extracellular vesicles;Florida;Functional disorder;Goals;Government;Health;Health Care Costs;Health Status;Human;Human Cell Line;immune modulating agents;improved;Individual;induced pluripotent stem cell;Industrialization;Inflammation;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;liquid biopsy;Mass Spectrum Analysis;Measures;Methods;minimally invasive;Modeling;molecular marker;Monitor;Morbidity - disease rate;new technology;novel;Pancreas;Pathologic;Patients;peripheral blood;Persons;Phase;Plasma;Population;prevent;prognostic;protein biomarkers;Proteins;Proteomics;protocol development;Protocols documentation;response;Sampling;screening;Slice;Solid;Stress;Subgroup;success;Surface;Technical Expertise;Techniques;Technology;technology validation;Tissue Sample;Tissues;United States;Universities

PROJECT_TITLE: Multimarker surface signatures of human islet derived extracellular vesicles


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: Persons who experience incarceration in the United States are disproportionately impacted by HIV infection and substance use disorders and are at increased risk of having poor health outcomes. The time of release from jails and prisons, known as community re-entry, is a period of particularly high risk and persons with HIV may fail to adhere to their HIV treatment. This study will investigate whether recently approved long-acting injectable HIV treatment, which is given every four weeks, as opposed to oral HIV medications taken daily, has the potential to improve HIV treatment outcomes among persons being released from correctional facilities.

PI_NAMEs: BECKWITH, CURT G (contact);BRINKLEY-RUBINSTEIN, LAUREN ;GORDON, MICHAEL SCOTT

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Anti-Retroviral Agents;antiretroviral therapy;Area;Baltimore;Behavioral Model;Clinical Trials;Collaborations;Communities;community engagement;community reentry;comorbidity;Contractor;Creativeness;Data;design;Development;Disease Progression;Dose;drug testing;Eligibility Determination;Environment;Epidemic;experience;FDA approved;Federally Qualified Health Center;follow-up;Funding;Future;Geography;Goals;Health;Healthcare;High Prevalence;high risk;high risk population;HIV;HIV Infections;HIV resistance;housing instability;Imprisonment;improved;Injectable;innovation;Interview;Intramuscular Injections;Jail;Justice;Maryland;Medical;Mental disorders;Methods;metropolitan;open label;Oral;oral HIV;Participant;Patient Recruitments;Persons;Pharmaceutical Preparations;pill;Pilot Projects;pilot test;poor health outcome;primary outcome;Prisons;Procedures;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Regimen;Relapse;Research;response;Risk;Role;Safety;Schedule;secondary outcome;Services;Site;substance use;Substance Use Disorder;substance user;Therapeutic;Time;transmission process;treatment adherence;Treatment outcome;Treatment Protocols;Unemployment;United States;United States National Institutes of Health;Urine;Viral;Viral Load result;viral rebound;Vulnerable Populations

PROJECT_TITLE: Long-acting injectable antiretroviral treatment to improve HIV treatment among justice-involved persons being released to the community


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Head and neck cancers are the sixth leading cause of cancer death worldwide, in part due to major challenges in patient stratification that have prevented the use of novel targeted therapeutics. The proposed work seeks to utilize three-dimensional (3D) culture models of oral cancers, the most common subsite of head and neck cancer, to better understanding of the biology associated with aggressive disease, as well as tumor features that may predict response to both standard and novel targeted treatments. We believe this approach is applicable beyond oral cancers, and the proposed work may support a paradigm shift toward using such 3D culture models to predict patient response to novel targeted therapies, particularly in the recurrent or metastatic setting.

PI_NAMEs: PARIKH, ANURAAG SUHRID (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 3-Dimensional;Adherent Culture;antitumor effect;Automobile Driving;biobank;Biological Models;Biology;Blocking Antibodies;cancer cell;Cancer Etiology;Carboplatin;Cell Line;Cells;Cessation of life;Cetuximab;chemotherapy;Cisplatin;Clinic;clinical predictors;Coculture Techniques;Coupled;CRISPR interference;Data;Development;Disease;Doxycycline;epithelial to mesenchymal transition;Epithelium;Fibroblasts;Fluorouracil;Foundations;Future;Genes;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;Immunodeficient Mouse;Immunohistochemistry;In Vitro;in vivo;in vivo Model;inhibitor;knock-down;malignant mouth neoplasm;Malignant Neoplasms;Mediator;Mesenchymal;Modeling;mouth squamous cell carcinoma;Mus;Neoplasm Metastasis;new therapeutic target;novel;Oral mucous membrane structure;Organoids;Paclitaxel;paracrine;Pathway interactions;patient response;patient stratification;Patients;predicting response;Prediction of Response to Therapy;predictive marker;Predictive Value;prevent;programs;Protein Isoforms;Recurrence;Regulation;Research Personnel;Resistance;response;response biomarker;Role;Seminal;Series;Signal Induction;Signal Transduction;single-cell RNA sequencing;Skull Base Chordoma;targeted agent;targeted treatment;Testing;TGFBR1 gene;transcription factor;Transforming Growth Factor beta;transforming growth factor beta3;Transplantation;Treatment Failure;treatment response;tumor;tumor growth;tumor heterogeneity;Tumor Promotion;tumor xenograft;Work

PROJECT_TITLE: 3D Culture Models of Partial-EMT and Its Regulation in Oral Cavity Squamous Cell Carcinoma


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Invasive lobular carcinoma (ILC) is a form of breast cancer that does not respond well to standard treatments like chemotherapy and hormone blockers and as a result is more likely to recur. HER2 activating mutations are found in a small percentage of ILC, and this oncogenic mutation can be treated with tyrosine kinase inhibitors such as neratinib. This study will use neratinib in combination with antiestrogens to treat early-stage ILC with the goal of demonstrating the clinical activity of the combination, improving breast conservation, and eventually, increasing the number of patients who have breast cancer cure.

PI_NAMEs: ARTEAGA, CARLOS L;KENNEDY, LAURA CARPIN (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;adhesion receptor;Adjuvant Chemotherapy;adjuvant endocrine therapy;Adjuvant Therapy;Agonist;Anti-estrogen Therapy;Apoptosis;arm;Aromatase Inhibitors;ATAC-seq;Biopsy;Breast biopsy;breast cancer survival;Breast conservation;Breast-Conserving Surgery;Cancer Burden;cancer subtypes;Caring;CASP3 gene;Cell Adhesion;Cell Cycle Arrest;Cells;chemotherapy;Clinical;Clinical Trials;Correlative Study;deprivation;Diffuse;Distant Metastasis;DNA;DNA sequencing;Drug resistance;drug response prediction;Drug Tolerance;E-Cadherin;Endocrine;Epigenetic Process;ERBB2 gene;Estrogen Antagonists;Estrogens;Evolution;Exclusion;FDA approved;Gene Amplification;Genes;Genetic Transcription;Goals;Gonadotropin Hormone Releasing Hormone;Growth;Histology;Hormone Receptor;hormone receptor-positive;hormone therapy;Hormones;Human;improved;In complete remission;In Vitro;indexing;Indolent;Induction of Apoptosis;inhibitor;innovation;Institution;Lead;Light;Lobular;Lobular Carcinoma;Longitudinal Studies;Malignant Breast Neoplasm;Menopausal Status;Metastatic breast cancer;Molecular;molecular marker;Molecular Target;mutant;Mutate;Mutation;Neoadjuvant Therapy;neoplastic cell;Newly Diagnosed;novel;Oncogenic;Operative Surgical Procedures;Organoids;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phase;Phase II Clinical Trials;phase III trial;Prevalence;prevent;Prognosis;prognostic index;programs;Proliferating;Proto-Oncogene Proteins c-akt;Randomized;receptor;Recurrence;Refractory;Repeat Surgery;Reporting;Residual Cancers;Residual Neoplasm;Resistance;Safety;Sampling;Signal Transduction;single-cell RNA sequencing;standard care;surgery outcome;synergism;Therapeutic Effect;Time;Trastuzumab;trial design;tumor;tumor diagnostic;tumor heterogeneity;Tumor Tissue;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Neoadjuvant Neratinib in Stage I-III HER2-mutated Lobular Breast Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Data Science;Genetics;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative To directly address the need to better prepare the scientific workforce for biomedical, behavioral, and clinical research, this program will design and establish a course to teach advanced statistical methods. This will be the “Training in Advanced Statistical Methods in Neuroimaging and Genetics” course.

PI_NAMEs: WELSH, ROBERT C. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Adolescent;Age;Alzheimer's Disease;Attention;Award;Back;Bayesian Analysis;Behavioral Research;Big Data;biobank;Biological Markers;biomarker development;Biomedical Research;Brain;Budgets;Classification;Clinic;Clinical;Clinical Research;cognitive development;cohort;Collaborations;Communities;complex data;Computers;connectome;Continuing Education;Data;data acquisition;Data Collection;Data Set;design;Disease;Education;educational atmosphere;Educational process of instructing;Effectiveness;Enrollment;Ensure;Equation;Expenditure;experience;Explosion;Faculty;Feedback;follow-up;Funding;Genetic;genetic analysis;Genomics;Geography;Grant;Growth;hands-on learning;Home;Human;Image;imaging genetics;implementation questions;Infrastructure;innovation;Institution;instructor;Internet;Investigation;Knowledge;Knowledge acquisition;Learning;lecturer;lectures;Linear Models;Measures;meetings;Meta-Analysis;Methods;Minority;Mission;Modeling;Monitor;Multimodal Imaging;multimodality;National Institute of Biomedical Imaging and Bioengineering;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;neuroimaging;Participant;patient population;polygenic risk score;Positioning Attribute;predictive modeling;Process;programs;Protocols documentation;Qualifying;rapid growth;Research;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;skills;Statistical Data Interpretation;Statistical Methods;Statistical Models;Structure;Student Selections;Students;success;Techniques;terabyte;theories;Time;Training;Travel;Underrepresented Minority;United States;United States National Institutes of Health;Woman;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Sexually Transmitted Infections;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: A group of bacteria called spirochetes cause syphilis, Lyme disease, leptospirosis, and are associated with periodontal diseases. The motility of these spiral- or flat waved shaped bacteria enable these micro-organisms to invade and damage host organs and tissues. Our long-term goal is to develop novel drugs that specifically target and inhibit this invasiveness for treating spirochetal diseases.

PI_NAMEs: CRANE, BRIAN R (contact);LI, CHUNHAO CHRIS

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affect;Affinity;Amino Acids;Animal Model;anti-microbial drug;Bacteria;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;Borrelia burgdorferi;cell motility;Cells;Cellular Morphology;chemical synthesis;Chemicals;Chemistry;cofactor;crosslink;Cryoelectron Microscopy;design;Development;Disease;drug development;emerging antibiotic resistance;Engineering;experience;experimental study;Filament;Flagella;flexibility;functional restoration;genetic approach;Goals;Growth;high throughput screening;Human;Immune Evasion;Immune response;Immune system;Impairment;improved;In Vitro;in vivo;Infection;inhibitor;insight;Invaded;Investigation;Joints;Knowledge;laser tweezer;Lead;Leptospira interrogans;Leptospirosis;Link;Lyme Disease;mechanical properties;Mechanical Stress;Membrane;microorganism;Modification;Morbidity - disease rate;Morphology;mortality;Motility;Motor;Movement;Mus;mutant;Mutation;novel;novel therapeutics;optic tweezer;Order Spirochaetales;Organ;Organelles;Organism;pathogen;Pathogenesis;Penetration;Periodontal Diseases;periplasm;physical property;Play;Polymers;Post-Translational Protein Processing;Prevalence;Prevention;Process;protein crosslink;Proteins;Reaction;Recombinants;resistant strain;Role;Rotation;Shapes;single molecule;small molecule;small molecule inhibitor;small molecule libraries;structural biology;Structure;Structure-Activity Relationship;Swimming;Syphilis;Testing;Therapeutic Agents;therapeutic lead compound;Ticks;Tissues;tool;Treponema denticola;Treponema pallidum;Treponema pallidum subspecies pallidum;United States;Variant;Virulence;Virulent;Yaws

PROJECT_TITLE: Toward novel therapies against Lyme disease through the inhibition of lysinoalaine cross-linking in the bacterial flagella.

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE  Cortical circuit flexibility is influenced by learning and impacted by repeated stressors. The proposed research will focus on how fear learning and chronic stress modulate cortical activity in local microcircuits and large-scale networks. This work will provide new insights into behaviorally relevant plasticity in visual cortical circuits with implications for basic science as well as stress-related pathophysiology.

PI_NAMEs: MOBERLY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Advisory Committees;Amygdaloid structure;Area;area striata;Arousal;Association Learning;Basic Science;Behavior;Behavioral;Brain;Brain region;career;cell type;Chronic stress;Committee Members;Cues;Disinhibition;Elements;Event;experimental study;extrastriate visual cortex;flexibility;foot;Fright;Functional disorder;Glucocorticoids;Goals;Image;imaging approach;information processing;innovation;insight;Interneurons;Lateral;learned behavior;Learning;Limbic System;Link;maladaptive behavior;Mediating;medical schools;Memory;Mentors;Modality;Modeling;Molecular;multiphoton imaging;Mus;Neocortex;neocortical;network architecture;neural;neural circuit;Neurons;neuroregulation;novel;optogenetics;Organism;Outcome;Output;Phase;Play;Population Heterogeneity;Population Projection;Positioning Attribute;Property;Punishment;Research;response;Rewards;Rodent;Role;Route;Sensory;sensory cortex;sensory stimulus;Shapes;Shock;Signal Transduction;skills;Stimulus;Stress;stressor;Structure;Synapses;System;Technical Expertise;Testing;Training;two-photon;Universities;Visual;Visual Cortex;Visual evoked cortical potential;visual information;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Fear learning-related reconfiguration of local and large-scale cortical networks


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Kidney Disease

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: There are over 150 different epithelia in the body, forming part of organs like the skin, kidney, liver, gastrointestinal tract and structures in the nervous system. Important questions still remain unanswered on how epithelial cells achieve their highly organized architecture, a process known as polarization, which is fundamental to a diverse array of epithelial functions. The objective of this proposal is to bridge this gap in knowledge by uncovering novel intracellular mediators that sort and escort surface proteins on their way to the cell surface and define pathways for epithelial polarization.

PI_NAMEs: CACERES, PAULO SEBASTIAN (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adaptor Signaling Protein;Apical;Architecture;Cell Adhesion Molecules;Cell membrane;Cell surface;Cells;Clathrin Adaptors;Diagnosis;Disease;disorder prevention;Endosomes;Epithelial Cells;Epithelial Physiology;Epithelium;flexibility;Foundations;Funding Mechanisms;Future;Gastrointestinal tract structure;Goals;Homeostasis;Individual;Kidney;kidney epithelial cell;Knowledge;LDL-Receptor Related Protein 2;Liquid substance;Liver;Maintenance;Mediating;Mediator;Membrane Proteins;Mission;Modeling;Molecular;National Institute of General Medical Sciences;Nervous System;novel;Organ;Pathology;Pathway interactions;Physiological;Process;programs;Protein Sortings;Proteins;Proteomics;Proximal Kidney Tubules;receptor;Recycling;Research;Role;Skin;Sorting;sorting nexins;Structure;Structure of retinal pigment epithelium;Surface;Testing;Time;Tissues;trafficking;Training Programs;vesicle-associated membrane protein

PROJECT_TITLE: Mechanisms of polarized protein sorting in AP-1B-deficient epithelia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Precision Medicine

ORG_CITY: SYRACUSE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Narrative Adults with intellectual disability experience significant health disparities. Although they may benefit from precision medicine research advances, they are underrepresented in research and understanding of the legal, ethical, and social consent challenges that present barriers to their inclusion in this research is limited. A stakeholder-engaged approach to studying key issues for engagement of this population in precision medicine research and designing a disability accessible, interactive, and protocol-tailored consent toolkit will respond to: (1) expressed needs of precision medicine researchers for practical tools; (2) scientific interest in engaging adults with intellectual disability in precision medicine research; and (3) the goal of promoting health equity through inclusive precision medicine research.

PI_NAMEs: MCDONALD, KATHERINE ELIZABETH (contact);SABATELLO, MAYA

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adult;beneficiary;Clinical;Cognitive;cognitive interview;Collaborations;Communication;Communities;community academic partnership;Consent;consent capacity;Data;Data Set;Decision Making;decision research;design;Disabilities experience;disability;Disease;Education;Educational workshop;empowerment;Enrollment;Ensure;Equitable healthcare;Equity;ethical, legal, and social implication;Ethics;Exclusion;experience;Family member;Feedback;field study;Fostering;Friends;Funding;Genetic;Genomics;Goals;Health;health care model;health disparity;health empowerment;health equity;health equity promotion;Health Professional;Human;insight;Institutional Review Boards;Intellectual functioning disability;interest;Intervention;Knowledge;Learning;Legal;meetings;member;Modeling;multimodality;non-genetic;novel;Online Systems;Peer Review;personalized approach;pilot test;Population;precision medicine;preference;Prevention;Prevention strategy;Privacy;Protocols documentation;Proxy;Publications;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Review Literature;Risk;Role;Scholarship;service providers;social;success;Surveys;Testing;Text;theories;Time;tool;treatment strategy;United States National Institutes of Health;usability;webinar;Work

PROJECT_TITLE: Including Adults with Intellectual Disability in Precision Medicine Research - Project ENGAGE


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Ending the US HIV epidemic will require evidence-based approaches tailored to the needs of racial/ethnic minority women—not often considered. This project fills a gap for personalized, mobile/patient navigation HIV adherence interventions for women of diverse cultural/linguistic backgrounds, living in a US HIV epicenter.

PI_NAMEs: DUTHELY, LUNTHITA M (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Adherence;Affect;Alcohols;American;Appointment;arm;Award;behavior change;Behavior Therapy;Caring;Clinic;Clinical;Cognitive Therapy;Communication;coping;culturally appropriate intervention;Data;design;Development;Diagnosis;Disparity;Drug usage;Economics;Education;effective intervention;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;empowerment;Epidemic;ethnic minority;Ethnic Minority Women;Ethnic Origin;evidence base;Evidence based intervention;Face;Feasibility Studies;Future;Goals;Haitian;Health;Health behavior change;health disparity;health literacy;Health Promotion;Health system;Healthcare;high risk;HIV;HIV Infections;Hybrids;Illicit Drugs;implementation determinants;implementation framework;implementation outcomes;implementation/effectiveness;improved;Incidence;Individual;innovation;instrument;International;Intervention;intervention effect;Interview;Language;Linguistics;literacy;Location;Marijuana;Measures;Mediator;medical appointment;Mental Depression;Mental disorders;Mental Health;Methods;mHealth;mhealth interventions;Minority;Minority Women;Modeling;motivational enhancement therapy;Multilingualism;National Institute of Drug Abuse;Not Hispanic or Latino;novel;Outcome;Participant;patient navigation;patient-level barriers;Patients;personalized approach;Persons;Pharmaceutical Preparations;pilot test;pilot trial;Population;Poverty;Problem Solving;Procedures;Process;Protocols documentation;psychoeducation;Race;racial minority;racial minority women;racism;Randomized;Randomized, Controlled Trials;Reminder Systems;Research;Research Personnel;resilience;response;Risk;safety net;scale up;Services;Site;social;social stigma;Spanish;standard of care;Structure;substance use;Substance Use Disorder;success;System;telehealth;Testing;Text Messaging;therapy design;Tobacco;Trauma;United States;United States National Institutes of Health;uptake;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: mCARES: An HIV Adherence Intervention to Support Racial/Ethnic Minority Women with/at-risk of Substance Use and Mental Health Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-V(02)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cardiovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Unhealthy alcohol use adversely impacts HIV care and is associated with multiple physical and mental health comorbidities, and racial and ethnic minorities are disproportionately affected. There is an urgent need to train new scientists in patient-oriented research, address disparities, and implement alcohol interventions in HIV care. This K24 renewal application extends a highly productive and successful research mentoring program to increase opportunities for mentees in these critical areas, and proposes new HIV and alcohol mentoring opportunities for diverse clinicians and junior scientists, especially for those from racial and ethnic minority groups under-represented in medicine.

PI_NAMEs: SATRE, DEREK D (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol related problem;alcohol research;alcohol risk;alcohol screening;Alcohols;antiretroviral therapy;Area;Award;Behavioral Sciences;Black Populations;California;cardiometabolic risk;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;care outcomes;career;Caring;Characteristics;cigarette smoking;Clinical;comorbidity;Continuity of Patient Care;Data;Data Set;Development;Diagnosis;Discrimination;Disparity;drinking;effective intervention;Electronic Health Record;Epidemic;ethnic difference;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;Event;experience;Faculty;Female;Funding;Goals;Grant;Grouping;Health;health care settings;health disparity;Health system;Healthcare;high risk population;HIV;HIV risk;HIV/AIDS;implementation intervention;implementation science;improved;Individual;infection rate;Infrastructure;innovation;Interdisciplinary Study;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Latinx population;Medical;medical specialties;Medicine;men;Mental Depression;Mental disorders;Mental Health;Mentors;mortality;multiple chronic conditions;novel strategies;Obesity;Outcome;Paper;Parents;patient oriented research;Patients;Pattern;person centered;Persons;physical conditioning;Play;Population;Population Heterogeneity;Positioning Attribute;Prevention;Probability;Productivity;professor;programs;psychiatric comorbidity;Psychiatry;Psychosocial Factor;Publishing;racial difference;racial disparity;racial diversity;racial minority;racial minority population;Registries;Reporting;Research;Research Personnel;Resources;Risk;Risk Behaviors;Risk Factors;Role;Sampling;San Francisco;Scientist;screening;Services;Sex Differences;Sexually Transmitted Diseases;social health determinants;social stigma;Subgroup;substance use;syndemic;therapy development;Training;Training Programs;transmission process;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Viral;Visit;Woman;Work

PROJECT_TITLE: Mentoring alcohol use intervention research in HIV health care settings

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Telehealth

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Gay and bisexual men who have sex with men (GBMSM) in the rural southern United States experience a disproportionate incidence of HIV and STIs. Despite this, HIV and STI testing uptake and pre-exposure prophylaxis (PrEP) initiation remain low among rural GBMSM. We propose a type 2 hybrid effectiveness- intervention randomized controlled trial to test the efficacy of a mobile app, Combine, to increase the uptake of HIV and STI testing and PrEP over a 24-month period among GBMSM in the rural South and to assess the effects of different implementation strategies on intervention maintenance.

PI_NAMEs: JONES, JEB  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Affect;AIDS prevention;Arkansas;arm;Awareness;Behavioral;Belief;Bisexual;Caring;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Communities;community organizations;community partners;Consensus;Coupled;cultural competence;Data;data access;design;Diagnosis;Diagnostic Reagent Kits;Discrimination;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness-implementation RCT;effectiveness/implementation hybrid;effectiveness/implementation trial;efficacy testing;Environment;Epidemic;Ethnic Origin;experience;Face;Focus Groups;follow-up;Frequencies;Funding;Future;future implementation;Gays;Health;health care settings;Health Personnel;Health Services Accessibility;HIV;HIV diagnosis;HIV/STD;Home;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation outcomes;implementation strategy;implementation/effectiveness;improved;improved outcome;Incidence;interest;Intervention;Interview;Knowledge;Leadership;Maintenance;Measures;men;men of color;men who have sex with men;Methods;mHealth;mhealth interventions;Minority;mobile application;motivational enhancement therapy;Outcome;Ownership;Participant;Policy Maker;Population;pre-exposure prophylaxis;Prevalence;prevent;Prevention program;prevention service;preventive intervention;Preventive service;Provider;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Risk Assessment;Rural;rural Americans;rural area;Self Administration;Self Efficacy;self testing;sexual identity;Social Environment;social health determinants;social stigma;standard of care;STI prevention;Stigmatization;Surveys;telehealth;Testing;testing uptake;transmission process;Transportation;trial design;United States;uptake;Urban Population;willingness;Work

PROJECT_TITLE: Evaluating the effectiveness of a mobile HIV prevention app to increase HIV and STI testing and PrEP initiation among rural men who have sex with men

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: Our current understanding is that the underlying mechanisms responsible for the efficacy of PARPis is mainly through a synthetic lethal interaction with tumor DNA repair defects (‘BRCAness’). In this application, we aim to investigate the mechanisms and molecular determinants of the therapeutic efficacy of PARPis as immunomodulating agents through the induction of transcriptomic changes, a previously unknown mechanism of action of PARPis. The knowledge gained in this study will have a significant impact in broadening the clinical applications of PARPis in immuno-oncology.

PI_NAMEs: YAP, TIMOTHY ANTHONY (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP ribosylation;Animal Model;Antitumor Response;bak protein;Biological Markers;Blood specimen;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;cancer cell;Cancer Model;cancer subtypes;carcinogenesis;CD276 gene;Cell model;Cells;Characteristics;Chromatin;Clinical;clinical application;clinical development;Clinical Research;Clinical Trials;clinically relevant;Data;Defect;Development;Dissociation;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;efficacy evaluation;Future;Genes;Genetic Transcription;Goals;homologous recombination;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immunooncology;immunoregulation;Immunotherapy;individual patient;inhibitor;inhibitor therapy;innate immune pathways;innovation;insight;Knowledge;Laboratories;Lead;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Mediating;Molecular;molecular subtypes;Molecular Target;mutant;neoplastic cell;Nicotinamide adenine dinucleotide;novel;pancreatic neoplasm;Patient Selection;Patients;PD-1 inhibitors;PDL1 inhibitors;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;pre-clinical;preclinical study;predictive marker;programmed cell death ligand 1;programmed cell death protein 1;Promoter Regions;Proteins;recombinational repair;Regulator Genes;response;response biomarker;Role;sensor;single-cell RNA sequencing;Single-Stranded DNA;Specimen;synthetic lethal interaction;Testing;Therapeutic;Transcriptional Regulation;transcriptomics;Translating;Treatment Efficacy;tumor;tumor DNA;Tumor Immunity;tumor-immune system interactions

PROJECT_TITLE: Transcriptomic mechanisms underlying the immune modulating function and therapeutic efficacy of PARP inhibitors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Lung;Patient Safety;Pulmonary Hypertension;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Pulmonary thromboembolism remains a major cause of death and illness in the western world and while treatment leads to resolution in some, many continue to have symptoms and some develop pulmonary hypertension, an elevation of the pressures of the lung circulation leading to heart failure. Computed Tomography (CT imaging is integral to the diagnosis of pulmonary thromboembolism and is routinely obtained as part of its work-up. In this study we propose to use novel quantitative imaging tools to characterize the lung and heart in patients with pulmonary thromboembolism to improve identification of chronicity, prognostication and prediction of response to treatment while at the same time developing a quantitative relationship between structural changes on imaging and functional impairment.

PI_NAMEs: RAHAGHI, FARBOD NICHOLAS (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute;Acute Disease;artery occlusion;Awareness;biomedical referral center;Blood Vessels;Cardiac;Cardiovascular system;Cause of Death;Cessation of life;Chronic;Chronic Disease;chronic thromboembolic pulmonary hypertension;Circulation;Classification;Clinical;clinical care;Clinical Data;clinical decision-making;Coagulation Process;Complex;Coupled;Data;deep learning;Development;Diagnosis;Diagnostic;Disease;disease classification;Distal;Dyspnea;Embolism;European;Evaluation;Evolution;Exercise;experience;follow-up;Functional disorder;Functional impairment;Future;Gases;General Hospitals;Heart;Heart failure;hemodynamics;Hospitals;Image;Image Analysis;image processing;Imaging Device;imaging modality;Impairment;improved;Individual;Intercept;Intervention;Lung;Lung Diseases;lung pressure;Massachusetts;Methods;Modeling;Morbidity - disease rate;mortality;Newly Diagnosed;novel;Obstruction;Operative Surgical Procedures;Outcome;outcome prediction;Patients;Phenotype;predicting response;prognostication;Prospective Studies;pulmonary arterial hypertension;Pulmonary Circulation;Pulmonary Embolism;Pulmonary Hypertension;Pulmonary Thromboembolism;Quality of life;quantitative imaging;Registries;Reporting;Reproducibility;Residual state;Resolution;Right Ventricular Dysfunction;Risk;Scanning;Selection for Treatments;serial imaging;Severities;Severity of illness;Specialized Center;surgery outcome;Symptoms;Time;treatment choice;treatment response;United States;Universities;Vascular Diseases;Western World;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Classification and Prognostication in Pulmonary Thromboembolism Using Computed Tomography Image Analytics

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative This K24 renewal will support ongoing mentorship of early career investigators from Africa and the United States in the conduct of patient-oriented research. The specific research aims leverage all aspects of my NIH- funded research program in Botswana to create new linkages between the Tsepamo Study and Botswana’s national pediatric HIV database; to evaluate a national rollout of long-acting injectable PrEP; to improve decisions related to delivery by cesarian section and train my current mentee in mentoring; and to identify specific children eligible for a safe analytic treatment interruption study, evaluate the acceptability of such an intervention, and support the independence of a senior laboratory-based mentee in Botswana in this field. The ultimate goal of my research and mentoring program is to support the most relevant scientific questions being asked by the next generation of researchers in Botswana.

PI_NAMEs: SHAPIRO, ROGER L (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescent;adverse birth outcomes;Africa;Award;Birth;Boston;Botswana;career;Caregivers;Caring;Cesarean section;Characteristics;Child;Childhood;Clinical Data;Clinical Trials;cohort;Communicable Diseases;COVID-19;Data;Data Collection;Data Set;data sharing;Databases;delivery complications;Diagnostic;DNA;early childhood;Education;Eligibility Determination;Exclusion;Factor Analysis;Faculty;Financial Support;Fostering;Funding;Future;global health;Goals;Government;Guidelines;high risk infant;High Risk Woman;HIV;HIV-infected adolescents;Hospitals;Immunologics;improved;Incidence;Individual;Infant;Injectable;Interruption;Intervention;Interview;intrapartum;Laboratories;Length;Link;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Measurable;Medical;medical complication;Mentors;Mentorship;Mothers;next generation;novel;Outcome;Participant;patient oriented;patient oriented research;pediatric human immunodeficiency virus;Perinatal;Postdoctoral Fellow;pre-exposure prophylaxis;Pregnancy;pregnant;programs;Provider;Qualifying;Regimen;Research;Research Activity;Research Personnel;Research Support;Risk;Risk Factors;Safety;Site;Specimen;Standardization;Structure;Students;surveillance study;Testing;testing uptake;Time;tool;Training;Travel;treatment program;treatment strategy;United States;United States National Institutes of Health;uptake;Vertical Transmission;Virus;Visit;Woman;Work

PROJECT_TITLE: Expansion of research and mentoring opportunities to reduce the burden of maternal and pediatric HIV in Botswana

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The overall goal of the Johns Hopkins-Mayo-NIA Murine Senescence Mapping Program (JMN- MSMP) is to create an Atlas of Senescence in mouse tissues that coincide with tissues being explored in the human SenNet. The JMN-MSMP team combines expertise in aging, senescence, immunology, single-cell analysis, data sciences, and innovative computational approaches to achieve this goal. We will define cellular and molecular features of senescence, elucidate the heterogeneity of senescent cells, and characterize their impact on other cells and tissues.

PI_NAMEs: BAKER, DARREN ;DE CABO, RAFAEL ;ELISSEEFF, JENNIFER H (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Age;Age related pathologies;Aging;animal data;Atlases;Biological;Biological Markers;Bone Marrow;Brain;Cataloging;Cell Aging;Cell Communication;Cells;circulating biomarkers;Code;Collaborations;Communication;Computer Analysis;computing resources;Data;Data Analyses;Data Coordinating Center;data integration;Data Science;Data Set;data sharing;data submission;Decision Making;Deposition;Development;dimensional analysis;Ensure;Epigenetic Process;FAIR principles;Funding;Genomics;Goals;Heterogeneity;Hippocampus;Human;Image;imaging modality;immunohistochemical markers;Immunology;in vivo;Infrastructure;innovation;Kidney;Laboratory mice;Lead;Leadership;learning algorithm;life span;Liver;Lymphoid Tissue;Maps;Methodology;Methods;Molecular;Monitor;Mouse Strains;Mus;National Institute on Aging;novel;novel marker;Outcome;Pathology;Phenotype;Physiological;Physiology;Plasma;Policies;Prevalence;Process;Productivity;programs;Proteomics;Protocols documentation;Reporter;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Sampling;scale up;screening;senescence;senescence associated secretory phenotype;senescent cell;Serum;sex;Shipping;single cell analysis;single cell sequencing;single cell technology;single-cell RNA sequencing;Skeletal Muscle;Skin;Specimen;Standardization;Techniques;Technology;timeline;tissue archive;Tissue Banks;tissue mapping;Tissues;transcriptomics;transfer learning

PROJECT_TITLE: JHU-Mayo-NIA Murine Senescence Mapping Program (JMN-MSMP)


PI_NAMEs: ELISSEEFF, JENNIFER H (contact)

PROJECT_TERMS: Adoption;Advisory Committees;Aging;analysis pipeline;arm;Atlases;Benchmarking;big data management;Biological;Cataloging;Collaborations;Communication;Computer Analysis;computerized data processing;conflict resolution;coping;Data;Data Analyses;Data Coordinating Center;Data Management Resources;Data Set;Data Storage and Retrieval;Development;Ensure;Evaluation;experience;Generations;Goals;Image;Immunology;improved;Institution;interest;internal control;Leadership;Length;life span;Maps;meetings;mouse genetics;Mus;new technology;operation;Procedures;Process;programs;Protocols documentation;Quality Control;Recording of previous events;Reporting;Research Personnel;response;senescence;sex variable;single-cell RNA sequencing;Site;Specimen;Standardization;Structure;System;Technology;Testing;tissue mapping;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-M]


PI_NAMEs: BAKER, DARREN  (contact)

PROJECT_TERMS: 3-Dimensional;Age;age related;Aging;aging related;Algorithms;ATAC-seq;Atlases;Bioinformatics;Biological;Biological Assay;Blood;CDKN2A gene;Cell Aging;Cell Communication;cell type;Cells;Chronology;Classification;Computing Methodologies;Consensus;Cytometry;Data;Data Analyses;data integration;data platform;Data Set;Detection;DNA Damage;Ecosystem;Environment;epigenomics;Excision;Exhibits;experimental study;Female;Flow Cytometry;genetic signature;Genomics;Goals;Hallmark Cell;Human;Image;imaging modality;Imaging technology;Infrastructure;Lamin B1;life span;Longitudinal Studies;male;Maps;metabolomics;Modality;Molecular;Mouse Strains;multimodality;Mus;novel;Nuclear;Pathology;Phenotype;Physiology;Plasma;Prevalence;programs;prospective;Proteomics;Reporter;Reporter Genes;Research Personnel;RNA;senescence;senescent cell;Serum;sex;single cell analysis;single cell technology;single-cell RNA sequencing;Small Nuclear RNA;spatial integration;specific biomarkers;Time;tissue mapping;tissue resource;Tissues;transcriptomics;transfer learning;Transgenic Model;Transgenic Organisms

PROJECT_TITLE: Biological Analysis Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Public Health Relevance Understanding sex and gender influences on health and disease is critical to improving the well- being of both women and men. This challenge requires the perspectives of scientists and stakeholders from varied disciplines working together. The VCU BIRCWH Program will train and develop independent investigators with a commitment to collaborative, interdisciplinary, research in women’s health and sex/gender influences on health.

PI_NAMEs: BOYAN, BARBARA D.;KORNSTEIN, SUSAN G. (contact)

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: addiction;Area;cardiovascular health;career;career development;Clinical;clinically relevant;community partners;Data Analyses;design;Development;Development Plans;Discipline;disorder risk;early-career faculty;Environment;Ethics;Faculty;Funding;Gender;gender difference;Generations;Goals;Health;Health Benefit;health care delivery;improved;Individual;Interdisciplinary Study;International;investigator training;life span;Malignant Neoplasms;Maternal and Child Health;Mental Health;Mentors;Minority;neuromusculoskeletal;novel;Obesity;Outcome;Personal Satisfaction;programs;Publications;Qualifying;recruit;Research;research and development;Research Design;Research Personnel;Role;Schools;Scientist;sex;Structure;Time;Training;Training and Education;Training Support;Transcend;Universities;Virginia;Wages;Woman;Women's Health

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FERTIG, ELANA  (contact)

PROJECT_TERMS: Age;Aging;analysis pipeline;Atlases;Biological;Biological Assay;Biological Markers;Cataloging;Cell Aging;Cell Communication;Cells;Chromatin;Collaborations;Collection;Communities;computational pipelines;Computer Analysis;Computer software;Computing Methodologies;Data;Data Analyses;data format;data integration;data management;data modalities;data resource;data reuse;Data Set;data sharing;data to knowledge;Disparate;Environment;FAIR principles;Female;Genetic Models;genetic signature;Goals;Heterogeneity;human data;Infrastructure;Lead;learning strategy;life span;machine learning classification;male;Maps;Methods;Modality;Modeling;Molecular;mouse genetics;Multiomic Data;multiple omics;Mus;novel;Phenotype;Process;programs;Regulation;Reporter;Reproducibility;Research Personnel;Resources;senescence;senescent cell;Services;single cell analysis;single cell ATAC-seq;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;spectrograph;Standardization;synergism;System;Technology;tissue mapping;Tissues;transcriptome sequencing;transcriptomics;transfer learning;Translating;Visualization

PROJECT_TITLE: Data Analysis Core


ORG_STATE: CA

PHR: Project Narrative The proposed research will contribute fundamental insights into how signaling through G protein-coupled receptors (GPCRs) is organized and regulated in the cell. Because GPCRs control essentially every physiological process, this new knowledge will be informative for the design of therapeutics to treat a wide range of diseases.

PI_NAMEs: BLYTHE, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Adenosine;Adrenergic Receptor;Affect;Agonist;Animals;Area;Ascorbic Acid;Behavior;beta-arrestin;Biochemical;Biochemistry;Biological Assay;Biology;California;Cardiovascular Physiology;Cell membrane;Cell model;Cell Physiology;Cells;Coupled;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;design;Disease;Endocrine;Endocytosis;Endosomes;experience;experimental study;Family;frontier;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Imaging Techniques;In Vitro;insight;Integral Membrane Protein;Knowledge;Label;Ligand Binding;Ligands;Link;Location;Maps;Mass Spectrum Analysis;Membrane;Mentors;Mentorship;Modeling;Molecular;Mutate;novel;Outcome;Output;Pathway interactions;Perception;Peroxidases;Phase;Phosphorylation Site;Physiological Processes;Polypeptide Hormones;Postdoctoral Fellow;protein activation;Protein Biochemistry;Protein translocation;Proteins;Proteome;Proteomics;receptor;Receptor Activation;receptor internalization;receptor recycling;Receptor Signaling;reconstitution;Recycling;Regulation;Research;Resources;response;San Francisco;Sensory;Signal Transduction;Signal Transduction Pathway;skills;Sorting;spatiotemporal;System;Therapeutic;therapeutic target;tool;Total Internal Reflection Fluorescent;trafficking;Training;training opportunity;Universities;Vasoactive Intestinal Peptide Receptors;VIPR1 gene;Work

PROJECT_TITLE: Mechanisms of spatiotemporal signaling by GPCRs


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The complexity of MRI, its multiparametric nature, and its myriad embodiments for the study of tissue structure, physiology and function, require systematic, modality-specific training. The proposed program entails all aspects of training physics and engineering concepts for MRI image acquisition, reconstruction and processing, in com- bination with preceptor-directed research.

PI_NAMEs: WEHRLI, FELIX W (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Functional Magnetic Resonance Imaging;Physiological;Training

PROJECT_TITLE: Training in Structural, Physiologic and Functional Magnetic Resonance Imaging