NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Lung;Women's Health Research

PHR: Project Narrative Tumor metastasis is the major cause of mortality in human breast cancer, and understanding the biological mechanisms of metastasis is crucial for improving cancer treatment. The Class I PI 3-kinase, PI3Kβ, is a signaling protein and plays critical role in tumor cell invasion, and in the stromal cells that support tumor cell invasion. Existing clinical trials with PI3Kβ inhibitors have focused on the inhibition tumor growth. However, studies defining the mechanisms by which PI3Kβ mediates tumor invasion may refocus future trials on the treatment of patients with metastatic disease.

PI_NAMEs: BRESNICK, ANNE R (contact)

PROJECT_TERMS: Address;Basement membrane;Binding;Biological;Biology;Blood Platelets;breast cancer metastasis;Breast Cancer Treatment;cancer therapy;Cell Adhesion;Cell Communication;Cell secretion;Cells;Clinical Trials;Coculture Techniques;Data;Disease;Distal;Endothelium;experimental study;Extracellular Matrix;Extravasation;Future;Grant;Growth;Human;IL8 gene;Immune;Immunologic Surveillance;improved;In Vitro;in vivo;inhibitor;insight;intravital imaging;Invaded;Kinetics;knockin animal;Lung;lung imaging;Macrophage;Malignant Breast Neoplasm;MCF10A cells;Measures;Mediating;Metastatic Neoplasm to the Lung;migration;mortality;Mus;mutant;Mutant Strains Mice;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neutrophil Infiltration;novel;paracrine;Paracrine Communication;Patients;pharmacologic;PIK3CG gene;Platelet aggregation;Play;pre-clinical;Primary Neoplasm;Process;Proteomics;PTEN gene;Publishing;recruit;Regulation;response;Role;Signal Transduction;Signaling Protein;Site;stemness;Stromal Cells;Supporting Cell;Testing;tumor;tumor behavior;Tumor Cell Invasion;tumor growth;Tumor-infiltrating immune cells;VEGFA gene;Wild Type Mouse

PROJECT_TITLE: PI3K Beta  regulation of tumor metastasis


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative (Project 2) Metastasis is the main cause of cancer death. While we have significant understanding of biological events occurring in the primary tumor and at the early steps of metastasis, much less is known about how late steps of metastasis at distant organs are regulated. The proposed work will study how key stem cell factors promote these late steps of metastasis. Our findings will help develop strategies for preventing and/or treating metastatic disease.

PI_NAMEs: GUO, WENJUN  (contact)

PROJECT_TERMS: Affect;Automobile Driving;Biological;Biology;Blood Platelets;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Control;Cancer Etiology;cancer stem cell;cancer therapy;Cell Communication;Cells;Cessation of life;chemotherapy;Clinical;Data;Disease;Distal;Distant;Distant Metastasis;Embryonic Development;Enzymes;Event;Exhibits;Extravasation;Frequencies;Genetic;GPX2 gene;Growth;HIF1A gene;Human;Hypoxia;Kinetics;knock-down;Link;Lung;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Measures;Mediating;Metastatic Neoplasm to the Lung;Minor;Modeling;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;NF-kappa B;NOTCH1 gene;novel;Operative Surgical Procedures;Organ;Outcome;Oxidation-Reduction;Oxidative Stress;paracrine;Pathway interactions;Patients;Play;Population;prevent;Primary Neoplasm;Production;programs;Property;Proteins;Reactive Oxygen Species;Refractory;Reporter;response;Role;Sampling;Signal Pathway;Signal Transduction;Site;STAT3 gene;stem;stem cell expansion;Stem Cell Factor;stem cell function;stem cells;stem-like cell;stemness;Stromal Cells;transcription factor;triple-negative invasive breast carcinoma;tumor;tumor initiation;tumorigenic;Up-Regulation;Work

PROJECT_TITLE: Role of SOX9 mammary stem cell factor in metastasis


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

ORG_STATE: MA

PHR: PROJECT NARRATIVE This Mid-Career Investigator Award aims to develop a formal mentoring program, expand high-quality patient- oriented research on frailty and outcomes of medical and surgical interventions, and cultivate Dr. Kim's capacity as a mentor and leader in aging research. This is relevant to public health because the growth of well-trained clinician investigators and new evidence will accelerate adoption of frailty in clinical decision-making for medically complex older adults. Thus, it accomplishes the National Institute on Aging's missions and initiatives by promoting personalized care to improve the health status of older adults.

PI_NAMEs: KIM, DAE HYUN  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Academy;Acceleration;Acute;Adopted;Adoption;Affect;Age;Aging;Award;Cardiology;career;career development;Caring;Clinical;clinical decision-making;Clinical Management;collaborative environment;Complex;Data;Data Scientist;Data Sources;Dedications;Disease;Elderly;Environment;Epidemiologist;Epidemiology;Faculty;feasibility testing;Fellowship;Fostering;frailty;functional outcomes;Funding;Future;Geriatrics;Goals;Grant;Growth;Health;Health Policy;Health Services Research;Health Status;Health system;Healthcare Systems;Heterogeneity;human old age (65+);implementation science;improved;indexing;Individual;individual patient;Institution;inter-individual variation;K-Series Research Career Programs;Leadership;Learning;Link;Measurement;Medical;medical specialties;Medicare;Medicine;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Mission;National Institute on Aging;older adult;older patient;Operative Surgical Procedures;Outcome;Paper;patient oriented research;Patients;Peer Review;personalized care;personalized medicine;Persons;Pharmacoepidemiology;Pharmacotherapy;Physiological;Pilot Projects;Population;Postdoctoral Fellow;primary care practice;programs;Proliferating;Public Health;Publishing;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;skills;standard of care;stressor;Students;Surgical Specialties;Training;Training Programs;Translating;treatment effect;treatment response;trend;Writing

PROJECT_TITLE: Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health Outcomes

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Genetics;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE Metastatic disease, the most common cause of breast cancer-related mortality, is mediated by cancer cells capable of disseminating and colonizing distant organs. We will determine the signaling events required for emergence of disseminating cancer cell phenotype (invasive and stem) during cancer cell extravasation. We will also determine if stem program is required for re-dissemination of these cancer cells from metastatic foci, a process that may perpetuate metastases even after the removal of the primary tumor. Since most patients with metastases are treated with chemotherapy, we will determine the effect of chemotherapy on these two processes. To capture the true biology of the tumor microenvironment we will employ novel technologies for in vivo imaging of large volumes of tissue along with our novel biosensors in the lungs, with single cell resolution, and over many days. The findings will enable us to identify molecular targets for future therapies that could be combined with chemotherapy to improve outcomes for patients with metastatic disease which is responsible for 90 percent of cancer related mortality.

PI_NAMEs: OKTAY, MAJA HRZENJAK (contact)

PROJECT_TERMS: Actins;Affect;base;Biology;Biosensor;Blood capillaries;Blood Circulation;Blood Vessels;Bone Marrow;Brain;cancer cell;cancer stem cell;Cell membrane;Cells;Cessation of life;Chemoresistance;chemotherapy;Circulation;curative treatments;Data;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Distant;Distant Metastasis;Endothelial Cells;Endothelium;Event;Excision;Extravasation;Future;genetic regulatory protein;Hypoxia;improved;improved outcome;in vivo;in vivo imaging;insight;intravital imaging;Life;Light;Link;Lung;lung colonization;lung imaging;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic breast cancer;Metastatic Neoplasm to the Lung;migration;Molecular Target;mortality;Neoplasm Metastasis;neoplastic cell;new technology;NF-kappa B;novel;Organ;Patient-Focused Outcomes;Patients;Phenotype;Phosphatidylinositols;Population;Primary Neoplasm;Process;Prognosis;programs;Protein Isoforms;Publishing;Regulation;Relapse;Resolution;Signal Transduction;Site;stem;stem cells;stemness;Tissues;transcription factor;tumor;Tumor Biology;tumor growth;tumor initiation;tumor microenvironment;Tumor-associated macrophages;Woman

PROJECT_TITLE: Mechanisms of linkage of stem and invasive phenotypes during metastatic colonization


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Rare Diseases;Sarcoidosis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The reason why some develop granulomatous diseases, such as the scarring lung disease sarcoidosis, while others do not, and why some develop more severe forms of this disease and in others disease resolves, is not well understood. This proposal will define factors that may explain why some people get sarcoidosis, while also defining new proteins, genes, biomarkers and potential mechanisms important in the development of this and other similar diseases, as well as helping us understand their disease course. In future studies, these factors may be tested clinically as diagnostic tests or predictors of disease and ultimately even targets for therapy.

PI_NAMEs: BHARGAVA, MANEESH  (contact);MAIER, LISA A

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Aryl Hydrocarbon Receptor;Bioinformatics;bioinformatics tool;Biological;Biological Markers;Biological Process;biological systems;biomarker identification;biomedical referral center;Biopsy;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Caring;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Classification;Clathrin;Clinic;Clinical;clinical application;clinical care;Clinical Data;clinically relevant;cohort;community setting;computerized tools;Cross-Sectional Studies;Data;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;differential expression;disabling disease;Disease;Disease Marker;Disease Progression;Disease remission;Enrollment;Event;Exclusion;fibrotic lung;follower of religion Jewish;Foundations;FRAP1 gene;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Granulomatous disease;Health;Heterogeneity;Immune;Immune response;Immune system;Immunology;Immunosuppressive Agents;Impairment;improved;improved outcome;insight;integrin-linked kinase;Interstitial Lung Diseases;Link;Lung;Lung Diseases;Mass Spectrum Analysis;Mediating;Minnesota;Modeling;Molecular;Morbidity - disease rate;mortality;novel;Outcome;Pathogenicity;Pathway interactions;Patient Outcomes Assessments;Patients;Performance;Persons;Phagosomes;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CG gene;Population;predictive marker;predictive modeling;Process;Prognosis;prognostic;Progressive Disease;prospective;Protein-Serine-Threonine Kinases;Proteins;Proteome;Proteomics;Publishing;Pulmonary Sarcoidosis;rapid diagnosis;Receptor Signaling;recruit;Reporting;Resolution;rho;Sarcoidosis;Severities;side effect;Signal Transduction;single-cell RNA sequencing;Smoking Status;Source;statistics;Systemic disease;targeted treatment;Testing;therapeutic target;tool;Transcript;transcriptome sequencing;Translating;Universities;unnecessary treatment;Validation;Work

PROJECT_TITLE: Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: The Yale Cancer Prevention and Control (CPC) Training Program aims to educate, train and mentor pre- and post-doctoral fellows in five thematic areas critical to CPC: cancer etiology, cancer outcomes, lifestyle behavioral interventions, implementation science and community-engaged research. These five areas were selected because they are critical domains in the spectrum of CPC research, they leverage strengths of our faculty, and they will ensure that T32 trainees with diverse interests will achieve pivotal growth through the program and become leaders in novel, impactful CPC research.

PI_NAMEs: IRWIN, MELINDA L (contact);MA, XIAOMEI

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer Control;cancer prevention;Training Programs

PROJECT_TITLE: The Yale Cancer Prevention and Control Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Women's Health Research

PHR: Project Narrative The Administrative Core provides a critical structure that promotes scientific communication, sound budget management, sharing of data and ideas, and timely reporting of progress. Core C will schedule regular meetings between project participants, insure integration of the PPG with the Einstein Cancer Center, and organize periodic reviews by the Internal and External Advisory Committees. Most important, Core C will promote the integration of scientific investigation to effectively achieve the goals of the Program Project.

PI_NAMEs: BACKER, JONATHAN M. (contact)

PROJECT_TERMS: Advisory Committees;Biology;Budgets;Cancer Center;cancer research center director;Communication;Consultations;data sharing;Goals;Investigation;Journals;Malignant Breast Neoplasm;meetings;Metastatic Neoplasm to the Lung;Participant;Periodicals;Preparation;Program Evaluation;programs;Progress Reports;Reporting;Research;Schedule;sound;Structure;Travel

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Protein folding is a key step in the expression of the genetic information; thus, failure to fold correctly leads to misfolding and aggregation associated with many pathological states. The long term goal of this Research Program is to understand how newly translated proteins fold in eukaryotic cells and elucidate how chaperones mediate the folding of newly synthesized proteins. Our proposed experiments are aimed at obtaining functional, mechanistic and structural insights into the role of chaperones in de novo folding through the close integration of in vitro and in vivo approaches with computational biology analyses.

PI_NAMEs: FRYDMAN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TITLE: Protein Folding in the Eukaryotic Cytosol

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Lung;Women's Health Research

PHR: Project Narrative  The Advanced Imaging Core provides, in eight core services, the staffing, expertise, equipment, and interpretive skills needed to evaluate and test mechanisms of metastasis at the secondary site of the lung. The Core centralizes unique equipment, and the knowledgebase for its proper validated utilization, in a way that grants prioritized access to the members of this Program Project Group and ensures the rigor and reproducibility of all of the experiments. Without the services provided by Core A, our understanding of these processes would be derived from model systems and/or end-stage assays that only approximate the physiology of lung metastasis. In contrast, our approach is uniquely able to provide the information about mechanism of in vivo behavior at the single cell level.

PI_NAMEs: ENTENBERG, DAVID  (contact)

PROJECT_TERMS: Anesthesia procedures;animal imaging;Animals;Behavior;Biological Assay;Biological Models;biological research;Biology;Biophotonics;Biosensor;cancer subtypes;Cells;Clinical;Collection;Consultations;Custom;Data Analyses;Data Collection;Dedications;digital pathology;Ensure;Equipment;experimental study;Goals;Grant;Health Services Accessibility;Histopathology;Hypoxia;Image;in vivo;Individual;intravital imaging;knowledge base;knowledgebase;Laboratories;Lasers;Lung;Malignant Breast Neoplasm;Maps;member;Metastatic Neoplasm to the Lung;Methods;Microscope;microscopic imaging;Microscopy;multi-photon;multiphoton microscopy;Neoplasm Metastasis;novel;Operative Surgical Procedures;photonics;Physiology;Preparation;Process;programs;Protocols documentation;Quality Control;Recurrence;repository;Reproducibility;Research;Research Personnel;Resolution;Resources;Role;Services;Site;skills;stemness;Technology;Testing;tissue fixing;triple-negative invasive breast carcinoma;Visceral metastasis;Work

PROJECT_TITLE: Advanced Imaging Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Language performance of children with cochlear implants (CI) lags behind that of normal-hearing children, and is highly variable. Our proposed study seeks to use pre-surgical brain MRI to predict post-surgical language outcomes in English- and Spanish-learning children with CI, and will evaluate whether neural prediction would improve outcome by identifying those children requiring a more intensive program of language habilitation.

PI_NAMEs: WONG, PATRICK C M;YOUNG, NANCY MELINDA (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acclimatization;Address;Adopted;Affect;Age;analytical method;Area;Attention;Auditory;Auditory area;auditory deprivation;Behavior Therapy;bilingualism;Brain;brain magnetic resonance imaging;Brain scan;Chicago;Child;Child Language;Childhood;Clinical;Cochlear implant procedure;Cochlear Implants;Cognitive;Communication;Communication impairment;cost;cost effective;Data;Dependence;Development;Effectiveness;Enrollment;follow-up;frontal lobe;Future;Goals;Habilitation;hearing impairment;Hong Kong;Household;implantation;improved;improved outcome;Individual;Inferior;innovation;Investigation;Knowledge;Language;Language Development;language impairment;language outcome;Learning;Left;lexical;Longitudinal Studies;Magnetic Resonance Imaging;Measures;member;Methods;Modeling;MRI Scans;neural;neurodevelopment;neuroimaging;normal hearing;Operative Surgical Procedures;oral communication;Outcome;outcome prediction;Parents;Pattern;peer;Performance;personalized learning;phonology;precision medicine;prediction algorithm;Prediction of Response to Therapy;predictive modeling;programs;Protocols documentation;Randomized, Controlled Trials;Readiness;Reporting;Research;research clinical testing;Research Personnel;Resources;Sensorineural Hearing Loss;Spanish;Spanish/English;Specificity;Standardization;Subgroup;success;syntax;Technology;Testing;theories;Time;tool;translational research program;treatment program

PROJECT_TITLE: Neural Prediction to Enhance Language Outcomes in Children with Cochlear Implant

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE – Core B (Flow Cytometry Analysis and Cell Sorting) Flow cytometry is an essential technology platform for the identification, characterization and isolation of specific cell types. Core B will provide equipment, services and expertise to enable the program investigators to leverage multiple state of the art instruments for analytical flow cytometry and preparative cell sorting. The resources and organization of Core B will ensure efficient and cost-effective application of advanced flow cytometry-based methods to facilitate experiments addressing the fundamental biology of cancer metastasis.

PI_NAMEs: PORCELLI, STEVEN A (contact)

PROJECT_TERMS: Address;Adopted;Antibodies;antibody conjugate;Area;Biological;Biology;Budgets;Cancer Biology;Cancer Center Support Grant;Cell Nucleus;Cell Separation;cell type;Cells;Characteristics;Complex;Core Facility;cost effective;Dedications;design;Development;Ensure;Environment;Epithelium;Equipment;experimental study;Faculty;Flow Cytometry;Fluorescence-Activated Cell Sorting;Fluorochrome;Funding;Gene Expression;Goals;high dimensionality;Human Resources;Individual;Infrastructure;innovation;Institution;instrument;interest;Lead;Malignant Breast Neoplasm;Mesenchymal;Metastatic Neoplasm to the Lung;Methodology;Methods;Neoplasm Metastasis;neoplastic cell;new technology;novel strategies;Phenotype;Population;Procedures;programs;Property;protein expression;recruit;Reporter;Research Personnel;Resources;Services;Signal Pathway;Signal Transduction;single cell analysis;single cell technology;Sorting;Speed;stem cells;stem-like cell;Structure;Suspensions;Techniques;Technology;technology platform;technology validation;Time;Tissues;tumor;tumor microenvironment;Update;Variant;Work

PROJECT_TITLE: Flow Cytometery and Cell Sorting Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Monitoring an individual's eating behavior will provide detailed understanding of the causal relationship between the eating activity and conditions such as problematic eating and obesity. Manual self-reports are often erroneous and biased. The availability of wearable video cameras makes it possible to objectively capture the eating activity. However, manually observing video frames to obtain the objective measure of eating is burdensome. Additionally, wearable video cameras pose privacy concerns in real-world settings. To overcome these challenges, we are developing an automated eating detection system to monitor real-time eating behavior via a privacy-conscious wearable device that individuals will wear. We will confirm eating activities in real time. Such automatic and privacy-conscious real-time eating detection will allow us to advance our understanding of the eating activity, laying the foundation for future interventions to change problematic eating behaviors.

PI_NAMEs: ALSHURAFA, NABIL  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Adherence;Age;Agreement;Algorithms;Assessment tool;Behavior;Behavioral Medicine;Bite;Body mass index;Calories;Cartoons;Chest;Chronic Disease;cohort;Conscious;Consumption;Controlled Environment;Cross-Over Trials;Cues;Data;Detection;detection platform;Devices;Diet;dietary;Dietary intake;Dietary Intervention;Ear;Eating;Eating Behavior;emotional eating;Energy Intake;Ensure;Equilibrium;Etiology;experimental study;Feeling;Female;food consumption;Foundations;Future;Gestures;Health;Health Promotion;hedonic;high risk;Hour;Hyperphagia;Hypertension;Image;improved;Impulsivity;Incentives;Individual;interest;Intervention;Knowledge;lens;Life Style;Locales;Machine Learning;Manuals;Measurement;Measures;Methods;miniaturized device;Monitor;Names;Neck;novel;Obesity;Output;Participant;Patient Self-Report;Pattern;Performance;personalized intervention;Persons;preservation;prevent;Privacy;Privatization;prototype;real time monitoring;Reporting;Research;Research Personnel;response;Risk;sensor;sex;smart watch;social;social influence;Speed;Suggestion;Surrogate Markers;System;Techniques;Technology Assessment;Testing;Time;tv watching;Video Recording;Visual;wearable data;wearable device;Weight Gain;willingness;Work;wrist worn device

PROJECT_TITLE: EAT: A Reliable Eating Assessment Technology for Free-living Individuals.

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Nearly 2 million are diagnosed with lung cancer each year and it is leading cause of cancer related death worldwide. There have been very few effective targeted therapies available, recent development of inhibitors that target KRASG12C directly a main oncogenic driver of NSCLC show promise in the clinic. Our work will determine possible modes of resistance to direct inhibition by studying allelic imbalance and co-mutated tumor suppressors.

PI_NAMEs: DIAZ, BIANCA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affect;Aftercare;Alleles;Allelic Imbalance;Apoptosis;Binding;Biology;Cancer cell line;Cancer Etiology;Cancer Patient;cancer type;CDKN2A gene;cell growth;Cell Nucleus;Cells;Cessation of life;chemotherapy;Clinic;Clinical;Clinical Management;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;cohort;Combined Modality Therapy;CRISPR library;Data;Development;Diagnosis;Disease;early phase clinical trial;EGFR inhibition;Environment;Epidermal Growth Factor Receptor;Evaluation;extracellular;Failure;Farnesyl Transferase Inhibitor;Future;gain of function;Genes;Genetic;genetic approach;Genetic Determinism;genome editing;Genotype;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Human;immune cell infiltrate;Immune checkpoint inhibitor;Immunophenotyping;improved;in vivo;in vivo Model;inhibitor;Knock-out;KRAS oncogenesis;KRAS2 gene;Libraries;loss of function;loss of function mutation;Lung Adenocarcinoma;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;MEKs;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel therapeutics;Oncogenic;Organoids;Outcome;Pancreas;Pathway interactions;Patients;Persons;Pharmacotherapy;pre-clinical;predictive marker;prevent;Prognosis;Proliferating;Proliferation Marker;Resistance;resistance mechanism;response;Role;Series;Signal Pathway;Signal Transduction;Silent Mutation;standard of care;STK11 gene;targeted treatment;Technology;Testing;Therapeutic;therapeutically effective;Toxic effect;TP53 gene;treatment response;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;vector;Work

PROJECT_TITLE: Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLC


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Estrogen;Genetics;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Bisphenol exposure in human populations is nearly universal and there is evidence that prenatal exposure to bisphenols is linked to negative neurodevelopment and behavior outcomes in children that continue throughout life. The proposed research will examine the biological mechanisms underlying the long-term effects of prenatal bisphenol exposure, including estrogen receptor signaling and DNA methylation changes, in the developing brain in rat models. Findings from this research project could help propose more targeted and effective interventions for children with prenatal bisphenol exposure to reduce risk of disease and promote healthier outcomes later in life.

PI_NAMEs: LAUBY, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Affect;analog;Animal Model;behavioral outcome;Binding;Bioinformatics;Biological;Birth;bisulfite sequencing;Brain;Caring;Child;chromatin immunoprecipitation;Competence;Consumption;Data Set;Development;differential expression;Disease;disorder risk;DNA;DNA analysis;DNA Methylation;Dose;effective intervention;Elements;Endocrine Disruptors;epidemiology study;ESR1 gene;estrogen disruption;Estrogen Receptor 2;Estrogen Receptors;Estrogens;experience;Exposure to;Female;Fetus;Food;Gene Expression;Genes;Genetic Transcription;Genome;Grooming;Health;Household Products;Human;Hypothalamic structure;Impairment;inter-individual variation;Life;Link;Location;Long-Term Effects;male;Medial;Methylation;Modeling;Modification;Mothers;Multiomic Data;Neonatal;neurodevelopment;offspring;Oral;Outcome;Placenta;Plasticizers;Plastics;Population;Positioning Attribute;postnatal;pregnant;prenatal;prenatal exposure;Preoptic Areas;Promoter Regions;Rattus;receptor binding;Receptor Signaling;Research;Research Project Grants;response;Risk Reduction;RNA Polymerase II;Rodent Model;Site;tactile stimulation;Tissues;Training;Transcript;transcriptome;Translational Research;Water

PROJECT_TITLE: Interactive Effects of Prenatal Bisphenol Exposure and Postnatal Maternal Care on DNA Methylation in the Developing Brain


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: There is currently a lack of engineers and scientists who have formal interdisciplinary training focused on regenerative medicine. This program will be used to develop an integrated training structure that provides a unique, multidisciplinary experience for postdoctoral fellows, allowing them to more efficiently translate scientific discoveries, with the ultimate goal of improving patient outcomes.

PI_NAMEs: GUILAK, FARSHID  (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TERMS: Regenerative Medicine;Training

PROJECT_TITLE: TRAINING IN REGENERATIVE MEDICINE


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative Ependymomas bearing ZFTA-RELA fusions in children carry a dismal prognosis and have no effective treatments. Our goal is to unravel how ZFTA-RELA drives epigenetic and metabolic pathways in these tumors. We aim to target metabolic pathways to develop treatments for this deadly childhood brain cancer.

PI_NAMEs: VENNETI, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acetates;Adjuvant Therapy;Age;Anatomy;Animal Model;antagonist;Automobile Driving;Biological;Biological Assay;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Brain region;Cancer Etiology;Carbon;Cell Line;Cells;Child;Childhood;Childhood Brain Neoplasm;Childhood Ependymoma;Childhood Malignant Brain Tumor;Chimeric Proteins;ChIP-seq;chromatin remodeling;Classification;Clinical Trials;Clinical Trials Design;combat;Complex;Critiques;Data;Dependence;effective therapy;Electroporation;Ependymoma;Epigenetic Process;Equilibrium;Exhibits;experimental study;Gene Expression;Generations;Genetic;Genetic Engineering;genome-wide;Glioma;Glucose;Glutaminase;Glutamine;Glutathione;Glutathione Metabolism Pathway;Goals;Homeostasis;Human;imaging biomarker;improved;in utero;In Vitro;in vivo;Individual;inhibitor;innovation;Interdisciplinary Study;Isotope Labeling;Knowledge;Maintenance;Malignant Neoplasms;Maps;Mediating;Medulloblastoma;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Molecular;Monitor;mortality;mouse model;neoplastic cell;novel;nutrient metabolism;Oncogenes;Oncogenic;Operative Surgical Procedures;Oxidation-Reduction;Oxidative Stress;p65;Pathway interactions;Pediatric Neoplasm;Positron-Emission Tomography;pre-clinical;precision medicine;Prognosis;programs;Proliferating;Proteins;PTEN gene;Radiation therapy;Reactive Oxygen Species;Recurrence;RELA gene;Research;Resistance;Role;Signal Transduction;standard of care;Supratentorial;System;targeted therapy trials;Testing;Therapeutic;therapeutic development;therapeutic target;Toxic effect;Treatment Efficacy;tumor;Tumor Promotion;Work

PROJECT_TITLE: Targeting metabolic dependencies in ZFTA-RELA fusion childhood ependymomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(02)M]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: AFDO Application for RFA-FD-22-008 - Retail Food Safety Regulatory Association Collaboration PROJECT NARRATIVE The Association of Food and Drug Officials proposes to build on the foundational work started in the original cooperative agreement and to collaboratively work with the other associations awarded in this new cooperative agreement to further advance retail food initiatives to improve retail food safety, identify opportunities to reduce the occurrence of foodborne illness risk factors, and improve foodborne outbreak investigation. The highlights of our plans for this cooperative agreement are outlined here but described in detail in the Research Strategy. AFDO will conduct another series of state retail food safety interviews and will include specific questions about key criteria for risk-based inspections and how they have been implemented within each state. We will use the information gathered to develop some key measurements and comparability among the states. We will add data to the Data Analytics project including data from additional jurisdictions and years of data, completing further analysis. Focus will be on analysis of key areas related to foodborne illness risk factors and the frequency of “not observed” in these areas. Further, we anticipate comparing the inspection results with the frequency of foodborne illness risk factor violations and type of certified food protection manager training required by the state. The state surveys will also include questions about barriers to Food Code adoptions and what tools could be helpful for state programs to complete adoptions of more recent Food Codes including key provisions. We will create a webinar on completing regulatory adoptions, which was cited as one of the key barriers to Food Code adoption. We will also maintain the interactive maps developed during the initial cooperative agreement, including changes to contact information. AFDO will continue identify and to promote food borne illness outbreak investigation tools and best practices for posting on the Collaborative website. In the area of Active Managerial Control, AFDO will put on a series of train-the-trainer courses developed under the initial cooperative agreement for corporations, develop and disseminate guidance documents, infographics, and best practices through data from an industry survey, and create a training resource for smaller/regional food industry operators. We will continue to deliver the Root Cause Analysis course developed under the first cooperative agreement to lead food safety regulators and industry professionals and continue offering Environmental Sampling courses which were determined as a need from CDC After Action Reviews. AFDO pledges to share all information received and tools developed with the other associations in the Collaborative.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH


PHR: Project summary and narrative not required per the RFA.

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Integrated Food Safety System Online Research and Collaboration Development


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Antimicrobial use is the major driver of the emergence of antimicrobial-resistant infections, a significant threat to human and companion animal health. Measurement of antimicrobials is critical to improve antimicrobial use for dogs and cats, however, efforts to collect this data are hampered by the nature of diverse pet health records and lack of resources and technical expertise in veterinary practices. This project will overcome barriers to tracking antimicrobial use by 1) utilizing a low-tech point prevalence survey approach to gather a snapshot of antimicrobial use in veterinary facilities across the country, and 2) establishing an electronic surveillance system for antimicrobial use that incorporates collection of uniform data across varied electronic health record platforms without the need for information technology expertise in participating practices.

PI_NAMEs: BEAUDOIN, AMANDA ;GRANICK, JENNIFER LEA (contact)

PROGRAM_OFFICER_NAME: HUEBNER, KATHERINE

PROJECT_TITLE: Representative, scalable, and sustainable surveillance methodologies to track companion animal antimicrobial use


ORG_CITY: ARLINGTON

ORG_NAME: ASSOCIATION OF STATE/TERR HLTH OFFICIALS

ORG_STATE: VA

PHR: Project Narrative State and territorial health agencies, along with other governmental agencies, help regulate food preparation, sale, and distribution, in addition to being primary responders to outbreaks of foodborne illness. The Centers for Disease Control and Prevention (CDC) estimates that 48 million people get sick, 128,000 are hospitalized, and 3,000 die from foodborne diseases each year in the United States. This demonstrates a serious strain on the food safety system and has led the public health community, including the Food and Drug Administration (FDA), to launch a Retail Food Safety Initiative to help achieve a better coordinated prevention-oriented food safety infrastructure. Through the activities in this proposal, ASTHO will further align its goals to that of FDA’s Retail Food Safety Initiative and work collaboratively with the Retail Food Regulatory Association Collaborative and help facilitate long-term improvements to the national food safety system.

PI_NAMEs: KULUNGARA, ABRAHAM GEORGE (contact)

PROJECT_TITLE: Strengthening Retail Food Regulatory Programs and Reducing Foodborne Illnesses through National Partnerships


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_DEPT: ANESTHESIOLOGY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Project Narrative: While acute kidney injury remains a major driver of morbidity and mortality in the perioperative period, the ability to accurately identify patients at risk for this complication remains limited despite decades of clinical research. The role of genetic information in predicting acute kidney injury remains largely unknown and requires large scale electronic health records and genomic datasets. We hypothesize that integrating patient data generated in the perioperative period into the most advanced predictive genomic algorithms, will enable a novel and personal risk assessment for postoperative acute kidney injury.

PI_NAMEs: DOUVILLE, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adoption;Affect;Algorithms;Anesthesia procedures;Anesthesiology;Apolipoprotein E;Assessment tool;Benchmarking;Bioinformatics;Board Certification;Caring;Chronic;Classification;Clinical;Clinical Data;Clinical Research;clinical risk;clinical training;clinically significant;cohort;Complex;Complication;Critical Care;Data;Data Science;Development;Diagnosis;Diagnostic;Disease;diverse data;Doctor of Philosophy;Electronic Health Record;Ensure;Environment;Exposure to;Family;Frequencies;Genetic;genetic analysis;genetic information;genetic variant;genome wide association study;genomic data;genomic predictors;Genomics;Goals;Growth;Health Personnel;Heritability;Hospitals;improved;Individual;Information Systems;Injury to Kidney;Institution;International;Investigation;kidney dysfunction;Knowledge;Laboratories;Learning;Medical;Medicine;member;Mentors;Mentorship;Methodology;Michigan;Modeling;Morbidity - disease rate;mortality;Nephrology;next generation;novel;Operative Surgical Procedures;Outcome;Outcomes Research;patient variability;Patient-Focused Outcomes;Patients;Peptidyl-Dipeptidase A;Perioperative;Perioperative complication;Pharmacologic Substance;Physicians;polygenic risk score;Population;Postoperative Period;Precision Medicine Initiative;prediction algorithm;predictive modeling;Prevention;Probability;Procedures;Process;Provider;public health relevance;Publishing;Records;Recovery;Research;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;Role;Sample Size;Scientist;Techniques;Testing;Time;TNF gene;Training;Training Programs;trait;United States National Institutes of Health;Universities;Update;Variant;Vocational Guidance

PROJECT_TITLE: Predicting Postoperative Acute Kidney Injury through Integration of Genetics and Electronic Health Records

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative The COVID-19 pandemic forced explosive growth of telehealth—synchronous virtual visits between patients and clinicians—under crisis conditions, but it is now essential to generate robust evidence regarding when telehealth’s benefits outweigh its risks in oncology practice; how to ensure that telehealth provides highly effective, efficient, and equitable care; and how to identify best practices for telehealth implementation. The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center will bring together investigators and trainees from multiple disciplines to meet these challenges by 1) conducting pragmatic and pilot trials across our integrated network of outpatient oncology practices; 2) leveraging our substantial cache of observational data to build the evidence base necessary to establish best practices for telehealth-supported cancer care; and 3) to investigate concerns about safety and addressing the risk of exacerbating disparities in access to high quality healthcare. Our Center’s theme focuses on developing data science methods to integrate telehealth data with other complex data streams to measure outcomes and quality of care.

PI_NAMEs: MORRIS, MICHAEL J;PANAGEAS, KATHERINE S (contact);SCHRAG, DEBORAH ;STETSON, PETER D

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Acceleration;access disparities;Address;Adoption;Ambulatory Care Facilities;analytical method;asynchronous communication;behavioral health;Biological Models;cancer care;Cancer Patient;cancer therapy;care delivery;Caring;Chronic;Clinic;Clinical Medicine;clinical practice;cluster randomized design;Communication;complex data;Computerized Medical Record;COVID-19 pandemic;Custom;Data;Data Science;data streams;design;Devices;Diagnosis;digital data;digital monitoring;digital tool;Dimensions;Discipline;Diverse Workforce;Dose;Ecosystem;Effectiveness;Electronic Health Record;Ensure;Equity;evidence base;experience;Explosion;Feedback;Future;Goals;Growth;Health Benefit;health care quality;health communication;health data;health equity;Health Services;Heart failure;Home;implementation science;Individual;individual patient;Inequity;Informatics;innovation;insight;Institute of Medicine (U.S.);Intervention;Intramuscular;investigator training;Knowledge;Laboratories;Link;Machine Learning;machine learning method;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;men;Metadata;Methods;mHealth;Modeling;multidisciplinary;New Jersey;New York;novel;Oncology;Oral;Outcome;Outcome Measure;Outpatients;Palliative Care;pandemic disease;patient portal;Patients;Pattern;personalized care;Persons;Physicians;pilot trial;pragmatic trial;precision oncology;prospective;Prostate Cancer therapy;Quality of Care;rational design;remediation;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Rural;Safety;Science;Site;skills;subcutaneous;survivorship;System;Techniques;telehealth;Testing;Time;tool;Training;trial comparing;trial design;virtual visit;Visit;Woman;Work

PROJECT_TITLE: MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe


NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative This program aims to train graduate students on the path to obtaining their PhDs to become translational research scientists and engineers who can integrate human biology and engineered systems to investigate and develop new technologies, diagnostics, and experimental therapeutics in patients and model disease systems. This competing renewal of our pre-doctoral training program in translational regenerative medicine remains a logical extension of the ongoing collaborative multidisciplinary research of the institute's outstanding faculty. WFIRM's unique infrastructure provides pre-doctoral trainees' access to RM experts and state-of-the- art facilities, allowing these trainees to be properly educated in the multidisciplinary field of RM, from basic science to translational applications, including the development of Phase 1 and 2 clinical trials.

PI_NAMEs: ATALA, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Regenerative Medicine

PROJECT_TITLE: Studies in Translational Regenerative Medicine


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

PI_NAMEs: MORRIS, MICHAEL J (contact)

PROJECT_TERMS: Age;authority;cancer care;cancer health disparity;care delivery;Caregivers;Caring;Clinic Visits;Clinical;clinical practice;Clinical Trials;Collaborations;Communication;complex data;data integration;Data Science;data streams;Decision Making;Dedications;design;digital divide;digital phenotyping;disability;Discipline;Discipline of Nursing;disparity reduction;Education;Educational workshop;Ensure;Environment;Equipment;Equity;equity, diversity, and inclusion;Evaluation;evidence base;Faculty;Feedback;Fostering;Funding Opportunities;Grant;health care quality;Health Policy;Health Services Research;Health system;Healthcare;high dimensionality;high risk;high risk population;Home;Infrastructure;innovation;Institute of Medicine (U.S.);Internet;Knowledge;Laboratories;Leadership;Learning;Malignant Neoplasms;Manuscripts;Measurement;Medicine;meetings;member;Mentors;Mentorship;Methods;Mission;Modeling;Oncology;Patient Care;patient engagement;patient oriented;Patients;peer coaching;Performance;personalized cancer care;Pharmacy facility;Pilot Projects;Policies;Positioning Attribute;Postdoctoral Fellow;Poverty;Practical Robust Implementation and Sustainability Model;pragmatic trial;programs;Protocols documentation;Public Health Informatics;Quality of Care;Race;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Activity;Research Methodology;Research Personnel;Resources;Running;Services;skills;Specialized Center;Structural Racism;Structure;Supervision;synergism;System;telehealth;telehealthcare;Testing;Theoretical model;Training;Training Activity;training opportunity;web site


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Telehealth

PI_NAMEs: PANAGEAS, KATHERINE S (contact)

PROJECT_TERMS: Acceleration;Administrator;Adult;advanced analytics;Algorithms;Ambulatory Care Facilities;analytical method;Artificial Intelligence;asynchronous encounter;Biometry;cancer care;Cancer Control;care delivery;career;Caring;Clinical Trials;Clinical Trials Design;Communication;Complex;Data;data integration;data management;Data Science;data standards;data streams;Development;digital;Digital biomarker;digital delivery;Educational workshop;effectiveness evaluation;electronic health data;Electronic Health Record;electronic patient reported outcomes;Equity;Evaluation;evidence base;experience;Family;Goals;Health;health care delivery;health data;Health Services Research;Health system;Healthcare;Healthcare Systems;Home;Hybrids;Immunooncology;Infrastructure;innovation;insight;Institution;interoperability;Intervention;Journals;Knowledge;Lead;Light;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Maps;Memorial Sloan-Kettering Cancer Center;Mentors;method development;Methodology;Methods;multidimensional data;novel;Oncology;Ontology;open source;Outcome Measure;Outcomes Research;Patient Outcomes Assessments;Patients;Peer Review;personalized cancer care;Pilot Projects;Play;Policies;Policy Maker;Postdoctoral Fellow;pragmatic randomized trial;pragmatic trial;Predictive Analytics;Provider;Publications;Qualitative Methods;randomized, clinical trials;recruit;Research;research and development;Research Methodology;Research Personnel;Resources;social media;Source;Source Code;Standardization;Statistical Methods;Stream;symposium;synchronous contact;Taxonomy;telehealth;telehealthcare;tool;Training;treatment as usual;trial comparing;trial design;user-friendly;Validation;web site;Work

PROJECT_TITLE: Research & Methods Core


ORG_CITY: HONOLULU

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE: OVERALL The Pacific Island Partnership for Cancer Health Equity (PIPCHE) represents the next step in augmenting a Hawai‘i-Guam-USAPI cancer research infrastructure by investing in Pacific Island Populations leaders, Early Stage Investigators, community partners, and community-informed disparities research. As a result of the 17- year commitment, PIPCHE is also well positioned to increase the diversity of the biomedical cancer science workforce and research leadership that better reflects the Hawai‘i-Guam-USAPI larger racial/ethnic representation and to stimulate new areas of disparities and translational research. PIPCHE has assembled dedicated academic and community partnerships needed to synergistically accelerate disparities research into a sustainable forum that pursues cultural and environmental appropriate solutions.

PI_NAMEs: HERNANDEZ, BRENDA YUKARI;LEON GUERRERO, RACHAEL T;PALAFOX, NEAL A. (contact)

PROGRAM_OFFICER_NAME: GHOSH, SANGEETA AHUJA

PROJECT_TERMS: Acceleration;Accreditation;Address;adolescent smoking;Advanced Malignant Neoplasm;Affect;American;anti-cancer research;Area;Areca;Asian;Awareness;Behavioral;Biological;Biology;Biometry;Cancer Burden;Cancer Center;Cancer Control;cancer education;Cancer Etiology;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Infrastructure;Cancer Research Project;cancer risk;Cancer Science;Clinical;Clinical Trials;Collaborations;Communities;Community Health;community organizations;Community Outreach;community partners;community partnership;Complex;Country;cultural competence;Dedications;Disparity;Distant;Economics;Education;education research;Enrollment;Environment;Epidemiology;Equity;Ethnic Origin;Evaluation;evidence base;expectation;Extramural Activities;Faculty;Funding;geographic population;Goals;Guam;Hawaii;Health;health care availability;health determinants;Health Educators;health equity;Health equity research;health literacy;Health Personnel;Health Sciences;Health system;higher education;improved;Incidence;Individual;Information Technology;Infrastructure;insight;Institution;Investments;Island;Knowledge;Leadership;Learning;Life Style;Location;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Marshall Islands;Mastication;member;Mentors;Minority;Minority-Serving Institution;Modeling;mortality;National Cancer Institute;NCI-Designated Cancer Center;neoplasm registry;Nuts;Obesity;Outcome;outreach;Pacific Island Americans;Pacific Islander;Pacific Islands;Pilot Projects;Policies;Population;population health;Positioning Attribute;Poverty;Prevention;Process;programs;psychosocial;public health intervention;Race;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Risk Factors;Screening for cancer;Series;Site;social;Socioeconomic Status;Students;Surveys;Survival Rate;Training;Translational Research;Underserved Population;United States;Universities;Work;Workforce Development

PROJECT_TITLE: (1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: PALAFOX, NEAL A. (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Cancer Center;Cancer health equity;career development;Collaborations;Communication;community advisory board;design;Development;Educational workshop;Effectiveness;Environment;Evaluation;Goals;Guam;Hawaii;Indigenous;Infrastructure;Institution;Leadership;Malignant Neoplasms;meetings;Mission;NCI-Designated Cancer Center;Office of Administrative Management;Pacific Islander;Pacific Islands;Population;Preparation;programs;Progress Reports;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resource Sharing;Science;Services;Universities;Vision

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The mechanisms by which the gastrointestinal microbiota influences host immunity remain poorly characterized. The intestinal epithelial cells integrate information from the microbiota, and relay these signals to the downstream immune system, therefore playing a key role as intermediaries in the effect of the microbiota on the entire body. In this project, we propose to study how the microbiota regulates intestinal epithelial cell death and how this can influence disease susceptibility and infectious disease outcomes with the goal of furthering our understanding of epithelial cell function, which will aid the design of new therapies to restore host immune function.

PI_NAMEs: MILLER, BRITTANY MARIE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Blood Circulation;career;CASP8 gene;Cell Death;Cell Physiology;Cells;Cellular biology;Colitis;Communicable Diseases;Defect;design;Development;differential expression;Disease;Disease Outcome;Disease susceptibility;Disputes;Epithelial Cells;Epithelium;expectation;experimental study;Exposure to;Face;Family;Family member;Future;gastrointestinal infection;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;Genes;Gnotobiotic;Goals;Growth;gut bacteria;gut colonization;gut inflammation;gut microbiome;gut microbiota;Health;Homeostasis;Host Defense;Host Defense Mechanism;host-associated microbial communities;host-microbe interactions;Human;immune function;Immune response;Immune system;Immunity;In Vitro;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;innovation;interest;intestinal epithelium;Intestines;Lead;Link;Macrophage;Mediating;member;Methods;microbial;microbiome;microbiome research;microbiota;microbiota metabolites;microorganism;Modeling;mouse model;Mus;novel therapeutics;Organ;pathogen;Pathogenesis;Pathway interactions;Physiological;Play;Predisposition;Production;Proteins;Regulation;Research;Research Personnel;Role;Salmonella;Salmonella typhimurium;Side;Signal Transduction;Site;Testing;Thinness;Tissues;Training;Up-Regulation;Work

PROJECT_TITLE: Regulation of the intestinal colonization niche by epithelial cell death


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research

PHR: PROJECT NARRATIVE We propose a case-control study of 300 liver fibrosis cases and 300 matched controls among Chamorros in Guam. Liver fibrosis, a well-established precursor of liver cancer, as well as liver steatosis as a secondary outcome, will be measured by transient elastrography (Fibroscan). We hypothesize that oral dysbiosis and sleep/circadian rhythm disturbance contribute to liver fibrosis through glucose and lipid dysmetabolism and the potential modifying effect of other exposures.

PI_NAMEs: HERNANDEZ, BRENDA YUKARI (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Alcohols;Areca;Bacterial Genes;Biological Markers;Blood;cancer health disparity;Cancer health equity;Case/Control Studies;Chronic Hepatitis C;chronic liver disease;circadian pacemaker;Circadian Rhythms;clinical examination;Collaborations;commensal bacteria;cryptochrome;Data;Diabetes Mellitus;Disease;dysbiosis;Early Intervention;Etiology;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Genes;Glucose;Guam;Hepatitis C virus;High Prevalence;Incidence;insulin signaling;Link;Lipids;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;Malignant neoplasm of liver;Mastication;Measures;Mediating;Metabolic;Metabolic Diseases;microbial;mortality;mRNA Expression;Native-Born;non-alcoholic fatty liver disease;novel;novel strategies;Nuts;Obesity;Oral;Oral cavity;Oral health;oral microbiome;Pacific Islands;Pathogenicity;Patient Self-Report;Patients;Pattern;Periodontal Diseases;Population;preventive intervention;Primary carcinoma of the liver cells;Questionnaires;Research;Risk;Risk Factors;Role;Sampling;secondary outcome;Severities;Sleep;sleep abnormalities;Sleep Apnea Syndromes;Sleep disturbances;Snoring;Stratification;United States;Viral hepatitis

PROJECT_TITLE: Full Project II:  Novel Risk Factors and Disease Associations of Liver Cancer in Guam


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Prostate Cancer;Telehealth;Urologic Diseases;Women's Health Research

PROJECT_TERMS: Acceleration;Agonist;Ambulatory Care Facilities;arm;asynchronous encounter;Blood;Breast Cancer Patient;cancer care;Cancer Center;Cancer Patient;capecitabine;care delivery;Caring;Clinic Visits;Clinical;clinical biomarkers;Clinical Data;Clinical Trials;cluster randomized design;Cluster randomized trial;Collaborations;Communication;Complex;County;COVID-19 pandemic;Custom;Data Analyses;Data Science;data streams;Development;digital;Digital biomarker;digital data;digital divide;digital platform;Dimensions;Economics;Effectiveness;effectiveness outcome;effectiveness trial;effectiveness/implementation hybrid;effectiveness/implementation study;Electronic Health Record;Eligibility Determination;Emergency Situation;Equity;Ethnic Origin;evidence base;experience;forging;Geography;GNRH1 gene;Goals;Health system;health training;Home;Home Care Services;hormone therapy;implementation facilitators;implementation outcomes;implementation process;improved;Informatics;innovation;Internet;Intervention;Intramuscular;Laboratories;Long Island;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;mHealth;Mission;Modeling;Motivation;multi-component intervention;New Jersey;Nurses;Oncology;Oral;Outpatients;Patient Care;patient engagement;patient portal;Patients;Perception;Persons;Policies;Poly(ADP-ribose) Polymerase Inhibitor;Population;pragmatic study;pragmatic trial;preservation;primary outcome;process improvement;Productivity;programs;prostate cancer model;Protocols documentation;Quality of Care;Race;Randomized;Reporting;Research Methodology;Research Personnel;Resources;routine care;Safety;secondary outcome;Selection for Treatments;Services;Site;Site Visit;stem;subcutaneous;Supervision;Surveys;synchronous contact;System;telehealth;Testing;tool;treatment as usual;Venous blood sampling;Vertebral column;virtual visit;Visit;Visiting Nurse;Visual;Work

PROJECT_TITLE: Pragmatic Trial


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative The neonatal thymus microenvironment consists of multiple stromal cell types which are critical for the development of T cells that protect newborns from infectious diseases and autoimmunity. The cellular and molecular differences between neonatal and adult thymic stromal cells and the mechanisms regulating the transition from neonatal thymus growth to adult homeostasis are not understood. This program project will use single cell RNA sequencing, advanced imaging and other cutting edge approaches to identify cellular and molecular changes in stromal cell subsets in the mouse and human thymus during the neonatal to adult transition, determine the molecular pathways that regulate these changes and evaluate the ensuing effects on T cell function.

PI_NAMEs: RICHIE, ELLEN R (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adolescent;Adult;Affect;age related;Antigen-Presenting Cells;Autoimmunity;autoreactive T cell;autoreactivity;B-Lymphocytes;Bioinformatics;Biological Process;Biology;Biometry;Birth;candidate identification;Cell Compartmentation;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular biology;Cellularity;central tolerance;Characteristics;Collaborations;Communicable Diseases;Communication Programs;Complement;Complex;congenital immunodeficiency;Cytoprotection;Data;Data Set;Dendritic Cells;Development;Emigrations;Environment;Epithelial Cell Proliferation;experimental study;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic Transcription;Goals;Growth;Hematopoietic;Homeostasis;Human;Image;Immune;immune function;Immune response;immune self tolerance;Immune Tolerance;Knowledge;Leadership;Life;Location;Macrophage;Maps;Mediating;Molecular;Molecular Analysis;multiplexed imaging;Mus;Nature;Neonatal;neonatal health;Newborn Infant;novel;Outcomes Research;Output;pathogen;Pathway interactions;Patients;Perinatal;perinatal period;Phase;Phenotype;phenotypic data;Play;Population;postnatal;Process;programs;Proliferating;Property;Publishing;rapid growth;reconstitution;Regulatory T-Lymphocyte;Reporting;Research;Research Project Grants;restraint;Retinoblastoma;retinoblastoma pathway;Role;Self Tolerance;Shapes;single-cell RNA sequencing;Stromal Cells;Structure;synergism;T-Cell Development;T-Lymphocyte;Testing;Thymic epithelial cell;Thymus Gland;Time;transcription factor;transcriptome sequencing;Visualization

PROJECT_TITLE: Mechanisms controlling distinct growth and functional characteristics of the perinatal and adult thymus


ORG_CITY: FULLERTON

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP)  Overall Component: Narrative This proposed P20 partnership will contribute to the enhancement of cancer health equity research in Orange County, California through the development of institutional capacities, support of meritorious joint cancer research pilot projects, and the provision of cancer research experiences and programs for underrepresented students. The long term goal is to increase the diversity of the cancer research workforce at both partnering institutions, and increase the number of investigators conducting cancer health equity research.

PI_NAMEs: TOLMASKY, MARCELO E (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Administrator;Advisory Committees;Advocate;African American;anti-cancer research;Applications Grants;Asian;Basic Science;Biological Sciences;Biotechnology;Breast Cancer Risk Factor;California;Cancer Center;cancer health disparity;Cancer health equity;cancer research center director;Collaborations;Communities;community engagement;community research;Comprehensive Cancer Center;County;Data;Development;disability;DNA sequencing;Education;Education and Outreach;education research;Educational Curriculum;Environment;Epidemiology;epidemiology study;ethnic diversity;Ethnic Population;Evaluation;experience;Faculty;Family;Fostering;Funding;Future;Genetic;Genomics;Goals;graduate student;Grant;Health Disparities Research;Health equity research;improved;innovation;Institution;institutional capacity;Institutionalization;Joints;Knowledge;Length;Lesbian Gay Bisexual Transgender Queer;lipidomics;Low income;Malignant neoplasm of ovary;Malignant Neoplasms;meetings;member;minority health;minority health disparity;mortality;Oranges;outreach;Pilot Projects;Population;Preparation;Principal Investigator;professor;programs;Recommendation;Records;Research;Research Personnel;Research Project Grants;Research Training;Sampling;Scientist;Seasons;student training;Students;System;Talents;Teacher Professional Development;Training;Training Activity;Training and Education;Training Programs;transcriptome sequencing;transcriptomics;treatment pattern;triple-negative invasive breast carcinoma;tumor;undergraduate student;underrepresented minority student;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 1/2 CSUF/UCI-CFCCC Cancer Health Disparities Research Program (CHERP)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MASKARINEC, GERTRAUD  (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Asian Pacific Islander;Asian population;Cancer Burden;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Center of Hawaii;career;career development;Caucasians;Collaborations;Communities;community based research;community intervention;curriculum enhancement;Degree program;Development Plans;Distant;doctoral student;Economics;Education;education research;Educational Curriculum;Educational workshop;Enrollment;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;experience;Faculty;follow-up;Funding;Future;Geographic Locations;Geography;Goals;Graduate Degree;graduate student;Grant;Guam;Hawaii;Health;health disparity;Health equity research;improved;Incidence;Individual;Institution;interest;Intervention;Island;Journals;Location;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Master of Science;meetings;member;Mentors;Micronesia;minority health disparity;mortality;novel;online course;Output;Pacific Islander;Pacific Islands;Pathway interactions;Peer Review;Population;Positioning Attribute;Postdoctoral Fellow;programs;psychosocial;Publications;Publishing;Race;Research;Research Assistant;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Scholarship;Series;skills;Students;success;Supervision;Time;Training;Training Activity;Travel;Underserved Population;Universities;Writing

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Telehealth

PI_NAMEs: STETSON, PETER D (contact)

PROJECT_TERMS: Acceleration;Administrator;Algorithms;arm;Awareness;Back;barrier to care;Businesses;cancer care;Cancer Center;care delivery;Caregivers;Caring;Chronic;Clinic;Clinical;clinical practice;Collaborations;comparative;Computer Models;Computer software;Continuity of Patient Care;cost;COVID-19 pandemic;Data;Data Analytics;Data Collection;data dashboard;data management;data modeling;Data Scientist;data standards;design;Devices;digital;Digital biomarker;digital divide;digital tool;Doctor of Philosophy;Education;Electronic Health Record;Ensure;Environment;Equity;Evaluation;evidence base;experience;Feedback;Foundations;Frontline worker;Future;health care model;health care quality;health data;Health system;Health Technology;Healthcare;Home;Hybrids;implementation science;informatics tool;Infrastructure;innovation;insight;Intervention;Intervention Studies;Investigation;Investments;Knowledge;Laboratories;Leadership;Learning;Location;Long Island;Malignant Neoplasms;Measures;Methods;Mission;model building;Modeling;Monitor;multidisciplinary;multimodal data;Nature;New Jersey;New York City;novel;Oncology;operation;Outpatients;Patient Education;patient engagement;Patients;Pilot Projects;pragmatic trial;Process;programs;Public Health Informatics;Quality of Care;Randomized;Recovery;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resources;Risk;Scientist;Secure;sensor;Services;Site;Standardization;Strategic Planning;success;System;Technology;telehealth;Testing;therapy design;Thinking;tool;Translating;treatment as usual;trial design;user centered design;Visualization;Work

PROJECT_TITLE: Clinical Practice Network


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Long term potentiation (LTP) is an important mediator of memory consolidation in the hippocampus. Understanding the differential roles that dopamine and norepinephrine contribute to LTP is of fundamental importance to understanding memory circuitry and its modulation. The results from this study will provide unprecedented insight into physiological memory consolidation, and potential implications for neuromodulation.

PI_NAMEs: GOYAL, ABHINAV  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Elucidating the neurochemical basis of LTP induction and maintenance in vivo


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Pacific Islanders are one the fastest growing ethnic groups in the US, found in every state. The work of the Pacific Island Partnership for Cancer Health Equity’s (PIPCHE) Community Outreach Core (COC) directly addresses the disproportionately high rates of cancer incidence and mortality found among Pacific Island Populations (PIP) in Hawai‘i and Guam. Using community-engaged approaches, the Community Outreach Core will work to support, enhance, and disseminate the PIPCHE’s research to better understand the determinants of cancer in this group. The COC’s activities will also serve to reduce the burden of preventable cancers found in PIP living in Hawai‘i and Guam, which may be applicable to groups found elsewhere in the US.

PI_NAMEs: CASSEL, KEVIN DARRYL (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Areca;Awareness;Behavior;Biological;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care providers;Cause of Death;Cervical Cancer Screening;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer screening;Communities;community engaged approach;community organizations;Community Outreach;Competence;Complex;Death Rate;design;Education;Equity;Ethnic Population;evidence base;experience;Failure;Filipino;Goals;Guam;Hawaii;Health;Health Educators;Health equity research;Health Personnel;Health Professional;high risk behavior;Human Papilloma Virus Vaccination;improved;Incidence;Knowledge;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;men;mortality;Nuts;Outcome;outreach;Pacific Islander;Pacific Islands;parity;Population;population based;Population Group;Prevention;Program Sustainability;Provider;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Development;Resources;Risk Reduction Behavior;Screening for cancer;social determinants;Students;Surveys;Tobacco;Training;underserved minority;uptake;Work

PROJECT_TITLE: Community Outreach Core


PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WILKENS, LYNNE R (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Biometry;Biostatistics Core;Biostatistics Shared Resource;Cancer Center;cancer health disparity;Cancer health equity;cancer risk;Collaborations;Consultations;Data;Data Analyses;data curation;data management;data resource;experience;Exposure to;faculty mentor;Guam;Hawaii;Health Disparities Research;health disparity;Incidence;Information Technology;member;Mentors;Methods;Monitor;novel strategies;outreach;Pacific Islands;Pilot Projects;Population;Prevalence;protective factors;Research;Research Design;Research Infrastructure;Research Project Grants;Resource Sharing;Respondent;Risk Factors;Role;Sampling;Scheme;sound;Students;Universities

PROJECT_TITLE: Core I: Biostatistics Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: anti-cancer research;Areca catechu;authority;Cancer Center;cancer health disparity;Cancer health equity;Data;Data Collection;data sharing;Development;Ethnic Population;Funding;Guam;Hawaii;Health Disparities Research;Health equity research;Incidence;Infrastructure;Interview;Joints;male;Malignant neoplasm of liver;Malignant Neoplasms;Mastication;Medical Records;mortality;multi-ethnic;neoplasm registry;Nuts;outreach;Pacific Islands;Patients;Pilot Projects;Play;Publications;Registries;Reporting;Research;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Secure;surveillance data;synergism;Territoriality;Training;tumor registry;Universities

PROJECT_TITLE: Core II:  Cancer Registry Core


PI_NAMEs: YI, S. STEPHEN  (contact)

PROJECT_TERMS: Adolescent;Adult;Antigen-Presenting Cells;Area;Bioinformatics;Biological;Biology;Biometry;Biostatistics Core;candidate identification;Cell Cycle;Cell Differentiation process;cell type;Cells;Characteristics;Collaborations;Data;Data Set;Data Storage and Retrieval;Dedications;design;Development;Educational process of instructing;Environment;epithelial stem cell;experience;experimental study;fetal;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;genomic platform;Goals;Grant;Growth;Hematopoietic;Heterogeneity;High Performance Computing;Human;human data;human disease;Individual;Informatics;Joints;Link;Maintenance;Malignant Neoplasms;Maps;Masks;medical schools;Methods;Modeling;Molecular;Mus;Pathway interactions;Perinatal;Population;post-doctoral training;programs;Publications;Research;Research Project Grants;Research Support;Sample Size;Secure;service utilization;Services;Signal Transduction;single-cell RNA sequencing;Standardization;Statistical Methods;Stromal Cells;success;synergism;Systems Biology;Technology;Texas;Thymic epithelial cell;Thymocyte Selection;Thymus Gland;transcriptome sequencing;Universities;Work

PROJECT_TITLE: Core B: Bioinformatics & Biostatistics Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  Surgical skill develops over the entire duration of a surgeon’s career, and well beyond their supervised training period. Currently, no methods for objective assessment of skill performance exist to identify and accelerate improvement in skill and, in turn, improve patient outcomes. This project develops a novel usable video-based personalized surgical learning platform, automated using artificial intelligence methods, for surgeons to effectively improve their skill.

PI_NAMEs: SIKDER, SHAMEEMA  (contact);VEDULA, SATYANARAYANA SWAROOP

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Active Learning;Acute;Address;Adoption;Adult;adverse event risk;Ambulatory Care;Artificial Intelligence;artificial intelligence method;Automation;Behavioral;Capsulorhexis;career;Caring;Cataract;Cataract Extraction;Competence;Complication;computer human interaction;Computer Vision Systems;COVID-19 pandemic;dashboard;Data;Data Science;deep learning;deep learning algorithm;Development;Devices;Education;Effectiveness;effectiveness evaluation;Elements;Ensure;Evaluation;experience;Faculty;Feedback;Foundations;Goals;Image;improved;improved outcome;Incentives;Information Retrieval;Institution;instrument;Intention;Intuition;Learning;learning progression;Libraries;Machine Learning;Measures;Methodology;Methods;multidisciplinary;novel;Operative Surgical Procedures;Ophthalmology;Outcome;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Performance;personalized learning;Procedures;Process;process improvement;prototype;Reproducibility;Research;Residencies;Resources;response;Risk;Risk Estimate;skill acquisition;skills;statistics;Structure;Surgeon;System;Technical Expertise;Testing;tool;Training;Translating;usability;user centered design;Work

PROJECT_TITLE: Artificial Intelligence Driven Tools for Objective Surgical Performance Improvement

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: ROBINETT, HALI  (contact)

PROJECT_TERMS: Cancer Center;Cancer health equity;Collaborations;Communication;Communications Media;Communities;Community Outreach;Consultations;Database Management Systems;education research;experience;Funding;Goals;Guam;Hawaii;Health equity research;Health Personnel;Industry;Informatics;Information Technology;Infrastructure;Institution;Maintenance;Malignant Neoplasms;outreach;Pacific Islands;Play;Research;Resource Sharing;Site;social media;student training;training opportunity;Universities;Videoconferencing;web site;Work

PROJECT_TITLE: Core III:  Information Technology Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Applications Grants;Asian Americans;Basic Science;Benchmarking;Biological Sciences;Biotechnology;California;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Catchment Area;Clinical Sciences;Collaborations;Communication;Communities;community based participatory research;community engagement;Comprehensive Cancer Center;Decision Making;design;Doctor of Philosophy;Education;education research;Educational Curriculum;Ensure;Epidemiology;ethnic diversity;Evaluation;experience;Family;Funding;Future;Geographic Locations;Goals;graduate student;Grant;Health Disparities Research;Health equity research;Hispanic;improved;Institution;Institutionalization;International;Knowledge;Leadership;Learning;Los Angeles;Minority;Molecular Genetics;Monitor;Native Americans;Office of Administrative Management;organizational structure;Outcome;Pacific Island Americans;Pacific Islander;pathogenic bacteria;Population Heterogeneity;Population Sciences;Principal Investigator;Process;professor;programs;Recommendation;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Resources;Scientist;Structure;Student recruitment;Students;success;System;Talents;Training;Training and Education;Training Programs;Translational Research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Virulence

PROJECT_TITLE: CHERP Administrative Core


NIH_SPENDING_CATS: Pediatric

PI_NAMEs: HALE, LAURA P. (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Age;Antigen-Presenting Cells;Architecture;biobank;Bioinformatics;Biology;Biostatistics Core;Board Certification;Cell Compartmentation;cell preparation;Cell Separation;Cells;Characteristics;Collection;Communities;Consultations;Critical Pathways;Cytoprotection;Data;Databases;Doctor of Philosophy;effector T cell;Ensure;Flow Cytometry;Foundations;Frozen Sections;Gene Expression;gene expression database;Gene Expression Profile;Generations;Goals;Growth;Hematopoietic;Heterogeneity;Histology;Homeostasis;Human;human tissue;Immunophenotyping;innovation;Institution;Knowledge;life span;Mediating;Modernization;Molecular;Molecular Analysis;molecular phenotype;Monitor;mouse model;Mus;Newborn Infant;pathogen;Pathologist;Pathology;Pathway interactions;Perinatal;phenotypic data;Population;Population Analysis;Procedures;Production;programs;Quality Control;Records;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Scheme;Self Tolerance;service utilization;Services;Signal Pathway;Sorting;Specific qualifier value;Standardization;Stromal Cells;synergism;T-Cell Receptor Genes;T-Lymphocyte;Thinking;Thymic epithelial cell;Thymic Tissue;Thymus Gland;transcriptome sequencing;translational potential;Translations;Vaccines;Work

PROJECT_TITLE: Core C: Human Thymus Core


NIH_SPENDING_CATS: Cancer

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Cancer biology research within this institutional, multidisciplinary training program is aimed at elucidating the molecular mechanisms responsible for initiation and progression of human cancer. Translational research is also directed at improving diagnosis and therapies for this terrible disease, and our training faculty have made discoveries that have led to new cancer therapies. Both pre- and postdoctoral trainees participate in rigorous didactic as well as state-of-the-art laboratory and/or computational research training with the earliest cadre having now established academic careers in cancer research.

PI_NAMEs: AARONSON, STUART A (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Training Program in Cancer Biology


NIH_SPENDING_CATS: Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Adolescent;Adult;Affinity;Age;Antigens;Atlases;autoreactivity;Binding Proteins;Binding Sites;Bioinformatics;Biological Assay;Biometry;candidate identification;capsule;CDK4 gene;Cell Compartmentation;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Differentiation process;Cell Lineage;Cellular Structures;Characteristics;ChIP-seq;Chromatin;Coupled;Cyclin D1;Data;Development;Differentiation and Growth;Epigenetic Process;Epithelial Cell Proliferation;epithelial stem cell;Event;experimental study;Family member;Gene Expression Profile;Gene Expression Profiling;Gene Family;Generations;Genetic;Genetic Transcription;Goals;Growth;Homeostasis;Human;Image;imaging approach;In Vitro;in vivo;in vivo evaluation;insight;keratin 5;Kidney;Knowledge;Link;Location;Maps;Mediating;Molecular;multiplexed imaging;Mus;Newborn Infant;Organ Culture Techniques;Organizational Change;Pathway interactions;Perinatal;perinatal period;peripheral lymphoid organ;Process;Production;progenitor;programs;Proliferating;promoter;Proteomics;Regulatory T-Lymphocyte;Reporting;Resolution;Retinoblastoma;Self Tolerance;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;T-Cell Development;T-cell receptor repertoire;T-Lymphocyte;Testing;Thymic epithelial cell;Thymic Tissue;Thymocyte Selection;Thymus Gland;Time;Tissues;Transgenes;Transplantation

PROJECT_TITLE: Project 1 - Molecular mechanisms controlling TEC dynamics and lineage hierarchies in the perinatal thymus


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: MANLEY, NANCY R (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age Months;Alleles;Bioinformatics;Biometry;Bordetella pertussis;Cell Compartmentation;Cell Differentiation process;Cell Physiology;cell type;Cells;Characteristics;Communicable Diseases;critical period;Cyclin-Dependent Kinases;Data;E2F transcription factors;Epithelial Cell Proliferation;Family member;fetal;Fetal Development;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Growth;Homeostasis;Human;immune function;Immune response;Influenza;life span;loss of function;Maps;Memory;mouse model;multiplexed imaging;Mus;mutant;Neonatal;neonatal period;Organ;Organ Size;Organizational Change;overexpression;pathogen;Perinatal;perinatal period;Peripheral;Pertussis;Phenotype;Population;postnatal;Process;programs;Proliferating;Publishing;Regulation;response;Retinoblastoma;retinoblastoma pathway;Retinoblastoma Protein;Role;single-cell RNA sequencing;stem cell population;stem cell proliferation;Stromal Cells;Stromal Change;T-Lymphocyte;Testing;Thymic epithelial cell;Thymus Gland;Tissue imaging;transcription factor;Transgenic Organisms;Vaccination

PROJECT_TITLE: Project 2 - The role of Foxn1 in controlling the transition from thymus expansion to homeostasis


NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Physical Injury - Accidents and Adverse Effects;Rehabilitation

PHR: PROJECT NARRATIVE The proposed work will identify specific home features which enable older adults with visual impairment to live safely, functionally, and, if they so choose, independently in their own home – a strong preference for most adults.18 Identification of such features will help intelligently define guidelines for home safety and functionality, and set up future randomized trials designed to evaluate the effectiveness of home modification programs to prevent falls and maintain functionality in persons with visual impairment.

PI_NAMEs: RAMULU, PRADEEP YAMMANURU (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accelerometer;Accounting;Admission activity;Adult;Affect;Age;Age related macular degeneration;Assessment tool;Calendar;Caregiver Burden;Clinical Trials;Clutterings;cohort;comparison control;Data;Death Rate;Defect;design;Development;disability;effectiveness evaluation;Environment;Environmental Hazards;Evaluation;Fall prevention;fall risk;falls;Floor;follow-up;Future;Glaucoma;Guidelines;hazard;Hazard Identification;Home;Home environment;Impairment;improved;Independent Living;Individual;Injury;injury-related death;innovation;instrumental activity of daily living;Lighting;Link;Location;Measures;Medical Care Costs;Methods;Modeling;Modification;Motor;National Eye Institute;novel;novel strategies;Nursing Homes;older adult;Performance;Persons;Physical activity;Positioning Attribute;preference;preservation;Printing;programs;prospective;Quality of life;Questionnaires;randomized trial;Research;Risk;Safety;Severities;System;Task Performances;Text;trial design;Vision;Visual impairment;Work

PROJECT_TITLE: Optimizing Safety and Functionality in the Visually Impaired


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE: The long-term goals of this project are to develop a patient-specific 3D cardiovascular tissue model and autonomous-flow (self-driven) microfluidic culture platform to assess the effects of pharmaceutical drug exposure on human myocardium in vitro and conduct fundamental studies of real-time cardiomyocyte-endothelial cell-extracellular matrix interaction for cardiomyopathy, atrial fibrillation, and atherosclerosis. The central hypothesis is that combining 3D cardiovascular tissue derived from human induced pluripotent stem cells with an autonomous-flow microfluidic device will create a patient-specific, physiologically relevant model that facilitates in vitro study of functional human myocardium. The primary impact of this work is the development of a targeted, single source cardiovascular tissue model that is more representative of the general population and will increase the efficiency of effective drug discovery by reflecting human response to the therapeutic while reducing the use of costly animal models.

PI_NAMEs: NATIVIDAD-DIAZ, SYLVIA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;Age;angiogenesis;Animal Model;Animals;Atherosclerosis;Atrial Fibrillation;Biochemical;Biological Process;Biophysics;Blood capillaries;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Cell Communication;Cell Culture Techniques;Cell Physiology;Cell Survival;Cells;Circulation;Coculture Techniques;Complex;coronary vasculature;cost;cost effective;Data;Development;Device Designs;Devices;Disease;Disease Progression;Dose;drug discovery;Drug Exposure;Drug Screening;drug testing;Encapsulated;Endothelial Cells;Ethnic Origin;Event;Extracellular Matrix;fluid flow;Future;Gender;Gene Expression;General Population;Genetic Variation;Goals;Good Manufacturing Process;Growth Factor;Human;human induced pluripotent stem cells;human stem cell-derived;Hyaluronic Acid;Immune system;improved;In Vitro;in vitro Model;in vivo;Intervention;Investigation;laboratory experiment;Liquid substance;Maintenance;manufacture;Methods;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;novel;Pathologic;Patients;personalized medicine;pharmacologic;Pharmacologic Substance;Physiological;pre-clinical;pressure;Process;Pump;Regimen;repaired;Reproducibility;Research;response;Sampling;Signal Transduction;Source;stem cell model;Stimulus;Stromal Cells;Structure;System;Technical Expertise;Testing;Therapeutic;Time;tissue culture;Tissue Model;Tissues;treatment response;Vascularization;Work

PROJECT_TITLE: 3D in vitro Human Stem Cell-derived Cardiovascular Tissue Model and Microfluidic Platform for Targeted Preclinical Drug Screening


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PHR: Pilot Project 2: Project Narrative Ovarian cancer survival is highest among Asian Americans relative to other races, but it is not the same across all Asian subethnic groups. Given the importance of the Asian American population’s heterogeneity when studying cancer, our pilot project will examine tumor characteristics and treatment care by Asian subethnic group to clarify ovarian cancer’s ethnic-specific survival disparities. The findings of this work will shed light on the underlying factors driving the ethnic-specific differences observed to inform strategies for addressing this highly fatal disease.

PI_NAMEs: LEE, ALICE  (contact)

PROJECT_TERMS: Address;Adherence;Asian;Asian Americans;Asian Indian;Automobile Driving;Behavioral;Biological;California;cancer health disparity;Cancer Patient;cancer survival;cancer therapy;Caring;Cessation of life;Characteristics;chemotherapy;Chinese;Consensus;Data;data registry;Data Sources;Disease;Disparity;Ethnic Origin;Ethnic Population;Female;Filipino;Future;Geographic Locations;Grant;Guidelines;Health Disparities Research;Heterogeneity;Histology;Home;improved;Incidence;Japanese;Koreans;Light;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;National Comprehensive Cancer Network;neoplasm registry;Operative Surgical Procedures;ovarian neoplasm;Patients;Pilot Projects;Population;Population Heterogeneity;Primary Neoplasm;programs;public health priorities;Publishing;Race;racial population;SEER Program;social;Socioeconomic Factors;socioeconomics;surveillance data;survival disparity;treatment planning;tumor;United States;Vietnamese;Woman;Work

PROJECT_TITLE: Examining the disparities in ovarian cancer survival among Asian Americans


PI_NAMEs: EHRLICH, LAUREN ILYSE RICHIE (contact)

PROJECT_TERMS: Activities of Daily Living;Adolescent;Adult;Affinity;age related;Agonist;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;Autoimmunity;autoreactive T cell;autoreactivity;Bioinformatics;Biological Assay;Biometry;candidate identification;Cell Communication;Cell Compartmentation;Cell Differentiation process;Cells;Cellularity;central tolerance;Characteristics;Collaborations;Data;Dendritic Cells;Environment;experimental study;Gene Expression;Gene Expression Profiling;Generations;Genetic Models;Genetic Transcription;Goals;Growth;Hematopoietic;Human;Impairment;Life;Location;Maps;Mediating;Molecular;Molecular Profiling;multiplexed imaging;Mus;Organizational Change;Output;pathogen;Perinatal;perinatal period;Phenotype;Play;Process;programs;Property;Regulatory T-Lymphocyte;Reporting;response;Role;Self Tolerance;single-cell RNA sequencing;Slice;Stromal Cells;T cell response;T-Lymphocyte;Testing;Therapeutic;Thymic epithelial cell;thymocyte;Thymocyte Selection;Thymus Gland;Tissue imaging;Tissues;two photon microscopy

PROJECT_TITLE: Project 3 - Differential contribution of thymic APCs to central tolerance during the perinatal to adult transition


ORG_CITY: DES MOINES

ORG_NAME: IOWA DEPT AGRICULTURE/LAND STEWARDSHIP

ORG_STATE: IA

PHR: ERPS Project Narrative Abstract The Bureau anticipates participation in this cooperative agreement will result in significant enhancement in the quality of inspections and inspectors egg and bio-security knowledge for Iowa's egg handling facilities. This will be obtained by achieving and sustaining full conformance with the Egg Regulatory Program Standards (ERPS), engaging in the annual face-to face meeting (if applicable) and participation in committees supporting ERPS, and working with FDA to establish the foundation for pursuing regulatory action based upon the findings of state inspections at state egg handler facilities. We intend to attain full conformance with the ERPS within 3 years and to put into place the tools necessary to allow continuous improvement and to ensure continued compliance once the funding is discontinued.

PI_NAMEs: GAMBLE, WILLIAM  (contact)

PROJECT_TITLE: IA ERPS Cooperative Agreement


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Myelin is essential for rapid nerve signaling and its loss in diseases like multiple sclerosis or after injury causes severe disability in patients. We propose to harness innovative tools and methods we developed to increase our fundamental understanding of how myelin forms normally during vertebrate central nervous system development, using both in vivo and primary cell culture approaches. These studies will contribute knowledge toward our ultimate goal of promoting remyelination in patients to reduce the burden of neurological diseases.

PI_NAMEs: ZUCHERO, JOHN B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Automobile Driving;Axon;cell fixing;cell motility;Cells;Cellular biology;Central Nervous System;Chronic;comparison control;Compensation;conditional knockout;Cytoskeleton;Data;Demyelinating Diseases;Development;disability;Disease;Dissection;Dorsal;Electron Microscopy;Foundations;Future;Genes;Genetic;Goals;Growth Cones;Image;Impairment;in vivo;Injections;Injury;innovation;jasplakinolide;Knowledge;Light;light microscopy;live cell imaging;Measures;Mediating;Membrane;Methods;Microfilaments;Microscopy;Modeling;Morphology;multidisciplinary;Multiple Sclerosis;Multiple Sclerosis Lesions;Mus;Myelin;Myelin Sheath;myelination;Neonatal;neonatal mice;nervous system development;Nervous System Disorder;neuronal growth;Neurons;neurotransmission;novel;Oligodendroglia;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phenotype;Positioning Attribute;prevent;Primary Cell Cultures;Process;promoter;Proteins;PTEN gene;remyelination;Reporter;Research;Resolution;Role;Specificity;Spinal Cord;Stains;superresolution microscopy;Techniques;Testing;Time;Tissues;tool;translational study;Vertebrates;Viral

PROJECT_TITLE: How Does Actin Disassembly Drive Myelin Wrapping?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]