ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE While the vast majority of human mutations are very rare, nearly all genetic studies of human disease exclude the rarest variants. We developed a method for inferring the contribution of all variants to phenotypic variation, and found that globally rare variants (MAF<0.1%) explain half of the genetic contribution to gene expression. In this study, we will functionally validate this finding using massively parallel reporter assays, expand our analysis to multiple human tissues, and improve genome-based precision medicine tools for all by studying the genetic architecture of complex traits across populations.

PI_NAMEs: HERNANDEZ, RYAN D. (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biology;causal variant;Communities;Complex;Data;Development;Disease;DNA;Enhancers;environmental change;Exclusion;Exhibits;exome;experience;Feedback;Frequencies;Gene Expression;Gene Expression Profile;Gene Frequency;Genetic;genetic architecture;Genetic Models;Genetic Risk;Genetic study;Genetic Variation;Genome;Genome engineering;genome sequencing;genome wide association study;Genomics;Genotype-Tissue Expression Project;Goals;Growth;Heritability;Human;Human body;human disease;Human Genetics;human tissue;Iceberg;improved;insight;large datasets;Learning;Mendelian disorder;Methods;Minor;Minority Groups;Modeling;Mutation;pathogen;Phenotype;Play;Population;Population Genetics;Population Heterogeneity;precision medicine;rare variant;Recording of previous events;Reporter;reproductive;Research;Research Personnel;Role;Sampling;Science;Shapes;Statistical Models;success;Technology;Testing;Time;Tissues;tool;trait;Trans-Omics for Precision Medicine;Transcriptional Regulation;transcriptome sequencing;Validation;Variant;whole genome;Work

PROJECT_TITLE: Rarely Common: Uncovering the dominant role of rare variants in the genetic architecture of complex human traits.

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ORANGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHAPMAN UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Thyroid hormones, known as T4 (thyroxine) and T3 (triiodothyronine), are synthesized in the thyroid gland on specific sites within the hormone precursor protein thyroglobulin. In this project, I will create mice with loss of T4 formation while preserving T3 formation in thyroglobulin which will, for the first time, establish the extent to which T4 is required for normal development, growth, behavior, hearing, body weight and composition, and thermoregulation. My studies will aid in our understanding of the defects and treatment of hypothyroidism, which affects 10% of the world’s population and constitutes the most common congenital endocrinopathy in humans.

PI_NAMEs: CITTERIO, CINTIA E. (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;Affect;Alleles;Animal Model;Animals;Behavior;Biochemical;Biological Assay;Blood;Body Composition;Body System;Body Weight;Breeding;C-terminal;career;Cell Culture Techniques;Childhood;Clinical;clinically relevant;Competence;Coupling;Cretinism;CRISPR/Cas technology;Data;Defect;deiodination;Development;Event;experience;experimental study;Functional disorder;Future;Gene Fusion;Genes;Growth;Hand;Hearing;hormone deficiency;hormone regulation;Hormones;Human;Hyperlipidemia;Hypothyroidism;In Vitro;in vivo;insight;Intelligence;interest;Iodination reaction;Knock-in;Mediating;Mentored Research Scientist Development Award;Metabolic;Modeling;Monoiodotyrosine;mouse model;Mus;Mutagenesis;mutant;N-terminal;Names;nano-liquid chromatography;neonate;novel;Obesity;Organ;Patients;Phenotype;Physiologic Thermoregulation;Physiological;Physiology;Play;Population;Positioning Attribute;preservation;Production;Protein Precursors;Proteins;Reaction;Recombinants;Regulation;Role;Site;skills;Source;success;Symptoms;tandem mass spectrometry;Testing;Thermogenesis;Thyroglobulin;Thyroid Gland;Thyroid Hormones;Thyrotropin;Thyrotropin Receptor;Thyroxine;Time;Transfection;Triiodothyronine;Validation;Variant;Vertebrates;Weight Gain

PROJECT_TITLE: The Role of Thyroglobulin in Thyroid Hormone Synthesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: This proposal seeks to discover how the neural stem and progenitor cells of the developing brain produce the large diversity of nerve cell types found in the human cerebral cortex. Developing therapeutic approaches to disorders of brain development ranging from major malformations to diseases such as autism and schizophrenia will require an understanding of the human-specific features of cortical development that are the subject of this study.

PI_NAMEs: KRIEGSTEIN, ARNOLD  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Architecture;autism spectrum disorder;Behavioral;Bioinformatics;Biological Models;Brain;Brain Diseases;cell type;Cells;Cerebral cortex;Cerebrum;Development;Disease;Etiology;Evolution;Genomics;Glioblastoma;Goals;Health;Human;Human Development;human disease;human model;human stem cell-derived;improved;in vitro Model;lissencephaly;malformation;Mus;nerve stem cell;neural;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;novel;Organoids;Outcome;Population Analysis;progenitor;Radial;Rattus;real-time images;Rodent;Role;Schizophrenia;Signal Pathway;Signal Transduction;single cell genomics;stem;stem cell expansion;stem cell population;stem cells;Structure;Study Subject;subventricular zone;Technology;Therapeutic;therapy development;Tissue Sample;Tissues

PROJECT_TITLE: Development and Expansion of the Human Cerebral Cortex


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative More than 20% of all Americans suffer from an autoimmune disease, like rheumatoid arthritis (RA) or Systemic Lupus Erythematosus (SLE). Tissue and organ damage in these diseases are caused by cells of the immune system, which produce inflammatory mediators and antibodies that recognize and bind to self-tissues. The goal of this proposal is to determine how different inflammatory signals in the body activate the immune B lymphocytes to make antibodies and inflammatory mediators and potentially contribute to protection from infection as well as autoimmune disease pathology.

PI_NAMEs: LUND, FRANCES E. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;Affect;American;Animals;Antibodies;Antibody Formation;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Cell Differentiation process;Cell Lineage;Cell Nucleus;Cells;chromatin remodeling;Chronic;chronic autoimmune disease;chronic inflammatory disease;Clinical;Cues;cytokine;Data;design;Development;Disease;Effector Cell;efficacious treatment;Equilibrium;Exhibits;experimental study;FDA approved;Financial Hardship;Funding;Genes;Genetic Transcription;Goals;Healthcare Systems;Human;human disease;Immune;Immune response;Immune system;Immunity;Immunoglobulin-Secreting Cells;immunopathology;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-2;interleukin-21;Intervention;IRF1 gene;Lead;Learning;Licensing;Ligands;Maintenance;Mediating;Medicine;Modeling;Molecular;Mus;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Population;PRDM1 gene;prevent;Production;programs;Property;Refractory;Reporting;Repression;Research;Rheumatoid Arthritis;Role;Severity of illness;Signal Transduction;STAT1 gene;STAT3 gene;Stat5 protein;synergism;Systemic Lupus Erythematosus;T-bet protein;Testing;Time;Tissues;TLR7 gene;transcription factor;Virus Diseases;Work

PROJECT_TITLE: Control of B cell differentiation by IFNg induced transcription factors

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative During normal development of heart valves and in the progression of valve disease, blood flow exerts fluid forces on the valves, but the effects of these forces on valve structure and function are not known. We will examine the effects of flow-dependent changes at the molecular and cellular levels in developing and diseased valves. The goal is to identify critical factors affected by blood flow that contribute to myxomatous valve disease and develop new therapies to prevent or stop the progression of valve disease.

PI_NAMEs: YUTZEY, KATHERINE E (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Ablation;Adhesions;Adult;Affect;aortic valve;beta catenin;Blood flow;congenital heart abnormality;connexin 37;Crystalline Lens;Data Set;Development;Disease;Disease Progression;Endothelial Cells;Endothelium;Exposure to;Extracellular Matrix;Family suidae;fluid flow;FOXC2 gene;Functional disorder;Gene Expression;Gene Proteins;Genes;Goals;heart function;Heart Valves;Homeobox;Homeostasis;Human;Infiltration;Liquid substance;Liver;Lymphatic System;lymphatic valve;Macrophage;Maintenance;malformation;Marfan Syndrome;mechanical force;Mitral Valve;Molecular;Morphogenesis;Morphology;mouse model;Mus;Mutation;neuron development;novel therapeutics;Pancreas;Pathologic;Patients;Permeability;Population;prevent;Reporting;Role;Side;Signal Induction;Signal Transduction;single-cell RNA sequencing;Stratification;Structural Protein;Structure;Tamoxifen;Therapeutic;Time;transcription factor;transcriptome sequencing

PROJECT_TITLE: Endothelial subpopulations in heart valve development and congenital heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-R(02)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed fellowship program, a partnership between Loyola University Chicago and Ukrainian Catholic University, aims to provide doctoral and post-doctoral bioethics training to Ukrainian fellows who will conduct conceptual and empirical research on research ethics as well as educate and consult with researchers and research ethics committee members across Ukraine. The development of research ethics scholars is critical to the protection of human research participants and public trust in global research.

PI_NAMEs: ANDERSON, EMILY E (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: behavioral and social science;Bioethics;Chicago;Competence;Consultations;Development;Development Plans;Education;Educational process of instructing;Educational workshop;Ethical Issues;Ethical Review;Ethics;Fellowship;Foundations;Funding;global health;Government Agencies;Health;Individual;Institution;International;Lead;Leadership;Mentors;Methods;Persons;Positioning Attribute;Postdoctoral Fellow;Process;programs;Research;Research Activity;Research Design;Research Ethics;Research Personnel;Research Training;Scholarship;Solid;success;theories;Training;Training Programs;Ukraine;Universities;webinar

PROJECT_TITLE: Loyola-Ukrainian Catholic University International Bioethics Research Training Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Kidney Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative To date, there is no known circulating biomarker for RCC. This project will interrogate samples from six clinical cohorts for KIM-1/TIM-1 as a potential blood test for RCC. Settings in which his will be tested include differentiating clear cell and papillary RCC from other renal masses, recurrence prediction in the adjuvant setting and following patients with metastatic RCC treated with targeted and immune therapies.

PI_NAMEs: MCDERMOTT, DAVID  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adjuvant;Adjuvant Study;Adjuvant Therapy;Angiogenesis Inhibitors;Angiomyolipoma;BAY 54-9085;Biological Markers;Blood;Blood specimen;Blood Tests;blood-based biomarker;Case/Control Studies;Cessation of life;checkpoint therapy;circulating biomarkers;Clear Cell;Clinical;clinical prognostic;Clinical Trials;cohort;Cohort Studies;Collection;Cyst;Data;Diagnosis;diagnostic biomarker;Disease;Disease-Free Survival;Early Diagnosis;Eastern Cooperative Oncology Group;Enrollment;European;Excision;Future;Gene Expression Profile;Goals;high risk;Histologic;immune checkpoint;Immunoglobulins;immunoregulation;Immunotherapy;improved;Individual;Injury to Kidney;Integral Membrane Protein;International;International Agency for Research on Cancer;Kidney Neoplasms;Lead;Localized Disease;Measures;Medical center;Metastatic Renal Cell Cancer;Monitor;mortality;Mucins;Nephrectomy;Operative Surgical Procedures;Outcome;outcome prediction;Papillary;participant enrollment;Pathologic;Pathology;patient population;Patients;Phase;Phase III Clinical Trials;Plasma;predict clinical outcome;Prediction of Response to Therapy;Prognosis;prognostic;Prognostic Factor;Prognostic Marker;prospective;Randomized;rat KIM-1 protein;Recurrence;relapse prediction;relapse risk;Renal Cell Carcinoma;Renal Mass;Resected;Retrospective cohort;Risk;Risk Assessment;risk stratification;RNA;Sampling;Screening for cancer;T-Lymphocyte;targeted treatment;Testing;Time;treatment response;tumor;Validation;Work

PROJECT_TITLE: Clinical characterization of Kidney Injury Molecule-1 (KIM-1) as a Biomarker in Renal Cell Carcinoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Neurons in the brain communicate using a large diversity of chemical signals and it is the concerted action of these signals that determine the activity and plasticity of neural circuits as well as animal behavior. We propose to follow up on previous findings from the lab that reveal that many individual neurons actually release multiple chemicals, each onto different classes of cells. We will determine how the integrated and simultaneous action of these molecules controls brain circuitry.

PI_NAMEs: SABATINI, BERNARDO L (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;Anatomy;Animal Behavior;Area;basal forebrain;Behavior;Biochemical;Biological Assay;Brain;brain circuitry;brain control;cell type;Cells;cellular targeting;Cerebral cortex;Chemicals;cholinergic;cholinergic neuron;Cholinergic Receptors;cognitive function;Communication;Corpus striatum structure;Cortical vasculature;Cyclic AMP-Dependent Protein Kinases;Data;Data Analyses;Development;Environment;Explosion;flexibility;follow-up;Funding;Future;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Gastrin releasing peptide;Genetic Transcription;Globus Pallidus;Grant;hippocampal pyramidal neuron;Individual;Interneurons;Laboratory Finding;Logic;Mus;Muscarinic Acetylcholine Receptor;Muscarinics;Nature;Nervous System;neural circuit;Neurodegenerative Disorders;Neuroglia;Neuromodulator;Neuronal Plasticity;Neurons;Neuropeptides;neuroregulation;neurotransmission;neurotransmitter release;Neurotransmitters;Outcome;Pathway interactions;Pattern;Peptides;postsynaptic;Process;Property;Pyramidal Cells;receptor;Recording of previous events;Regulation;response;Signal Transduction;Signaling Molecule;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;Testing;Time;Vasoactive Intestinal Peptide

PROJECT_TITLE: Action and interaction of ionotropic and metabotropic neurotransmission


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative: This proposal focuses on the pathogenesis of hypertrophic and dilated cardiomyopathies caused by mutations in the cardiac sarcomere. These are complex disorders and recent clinical studies suggest that early treatment may significantly improve patient outcome. We thus propose to use our combined computational and biophysical program coupled to our mouse models of genetic cardiomyopathies to identify new disease targets.

PI_NAMEs: TARDIFF, JIL C (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Actomyosin;Address;Alleles;Animal Model;Animals;Basic Science;Biological Markers;Biology;biomarker discovery;Biophysical Process;Biophysics;Cardiac;Cardiomyopathies;Clinical;Clinical Research;clinically relevant;Collection;Complex;Computer Analysis;Coupled;Couples;Cryoelectron Microscopy;Cytoplasm;Data;Development;Dilated Cardiomyopathy;Disease;Disease Progression;Dissociation;drug discovery;drug testing;Early treatment;Exercise;flexibility;Fluorescence Resonance Energy Transfer;Foundations;Funding;Future;Gene Expression Profile;Genes;Genetic Transcription;Genotype;Goals;Human Genetics;Hypertrophic Cardiomyopathy;Impairment;improved;In Vitro;in vivo;Individual;inherited cardiomyopathy;inhibitor;insight;Kinetics;Knowledge;Lead;Link;Measurement;Methodology;Microfilaments;Modeling;Molecular;mouse model;mutant;Mutation;Myosin ATPase;novel;novel strategies;Organ;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patient-Focused Outcomes;Patients;Pattern;Performance;Phenotype;Positioning Attribute;Process;prognostication;programs;Protein Dynamics;Protein Isoforms;protein protein interaction;Proteins;reconstitution;Relaxation;Resolution;response;Rest;Sarcomeres;Side;Signal Pathway;Signal Transduction;Site;Spectrum Analysis;stressor;Structure;System;Techniques;Testing;Therapeutic;Thin Filament;Time;tool;Transcriptional Activation;transcriptome sequencing;transcriptomics;Transgenic Animals;Transgenic Mice;Tropomyosin;Ventricular Remodeling;Work

PROJECT_TITLE: Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(02)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: PROJECT NARRATIVE This project is designed to utilize medicinal chemistry to optimize hits from our previous high throughput screening of small molecules with activity to mimic or enhance secretin activity at its receptor, and to demonstrate activity in a rat model of heart failure. We hope to identify drug candidates with ability to safely and effectively improve clinical outcome for patients with heart failure by targeting this receptor, with potential to enhance the ability of the heart to contract more effectively and to act on blood vessels to bring more blood to the heart and improve peripheral circulation, as well as improving appetite control and glucose metabolism.

PI_NAMEs: ARDECKY, ROBERT ;MILLER, LAURENCE J (contact);SERGIENKO, EDUARD A.

PROJECT_TERMS: absorption;Acute;Adipocytes;Affect;Agonist;analog;Angiotensin Receptor;Animal Model;Biological Assay;Biological Availability;Blood;Blood Vessels;Cardiac;Cardiac Output;Cardiovascular Diseases;Cardiovascular system;Cell model;Chemicals;Chemistry;Circulation;Clinical;Clinical Trials;Communities;Congestive Heart Failure;Contracts;coronary perfusion;Data;design;Desire for food;Development;Diabetes Mellitus;drug candidate;Drug Combinations;Drug Kinetics;EFRAC;enzyme substrate;Epidemic;Excretory function;Exhibits;FDA approved;Funding;Future;G-Protein-Coupled Receptors;Glucose;glucose metabolism;Goals;Grant;Half-Life;Heart;Heart failure;high throughput screening;Hospitalization;improved;In Vitro;in vitro Model;in vivo;Incidence;islet;Lead;lead series;Life;Medicine;Metabolism;meter;Modeling;Modification;Morbidity - disease rate;mortality;Myocardial;Myocardial Ischemia;Myosin ATPase;Natriuretic Peptides;Neprilysin;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral;Outpatients;Oxygen Consumption;parenteral administration;Patient-Focused Outcomes;Patients;peptide hormone;Peptide Hydrolases;Peptides;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plasma;Population;positive allosteric modulator;Prognosis;Property;Protease Inhibitor;Rattus;readmission rates;receptor;Receptor Signaling;Reporting;Reproducibility;Rodent;Satiation;scaffold;Secretin;secretin receptor;Series;side effect;Signal Pathway;small molecule;Specificity;standard of care;System;targeted treatment;Therapeutic;Therapeutic Agents;therapeutic effectiveness;Therapeutic Intervention;Thiadiazoles;treatment strategy;Validation;Vascular resistance;Work

PROJECT_TITLE: Activation of the Secretin Receptor as a Strategy for the Treatment of Heart Failure

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Negative affective disturbances, including stress, anxiety, and depression, are characteristic of alcohol abstinence, and a leading cause of relapse. A greater understanding of the complex neural circuitry regulating the disease state will lead to better diagnostic tools and treatment options for abstinence-induced negative affect. This project will investigate the functional state of the insular cortex-bed nucleus of the stria terminalis neural pathway in alcohol abstinence, two regions implicated in alcohol use disorders and negative affect.

PI_NAMEs: CENTANNI, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;addiction;Affect;Affective;affective disturbance;Affective Symptoms;alcohol abstinence;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol seeking behavior;alcohol use disorder;Alcoholism;Amygdaloid structure;Anterior;anti-depressive agents;Anxiety;Anxiety Disorders;associated symptom;Automobile Driving;Award;Awareness;Behavior;binge drinking;Brain;Brain imaging;Calcium;career;career development;Cell Nucleus;cell type;Characteristics;Chronic;Chronic Phase;cognitive control;comorbidity;Complex;Coupled;craving;Data;designer receptors exclusively activated by designer drugs;Diagnostic;diagnostic tool;Disease;drinking;Electrophysiology (science);Emotional;Exhibits;Family;feeding;Fiber;Financial Hardship;Food;Genetic;genetic approach;genetic manipulation;Genetic Recombination;Genetic Techniques;Goals;Health;Heterogeneity;hindbrain;Human;Hyperactivity;in vivo;Individual;Insula of Reil;Interneurons;Link;Major Depressive Disorder;Mental Depression;Mental disorders;Mentors;Midbrain structure;Motivation;mouse model;Mus;negative affect;Negative Reinforcements;neural;neural circuit;Neural Pathways;neuroadaptation;neuroimaging;Neurons;novel;Output;Pathway interactions;Patients;Pattern;Phase;Photometry;Physiological;Play;Post-Traumatic Stress Disorders;Predisposition;problem drinker;prophylactic;Regulation;Relapse;Reporting;Research;Role;Sensory;Severities;Severity of illness;side effect;social;Somatosensory Cortex;Source;Stress;stress related disorder;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Symptoms;Synapses;Testing;Thalamic structure;Therapeutic;therapeutic target;Time;Training;Viral;Virus;virus genetics;Withdrawal;Work

PROJECT_TITLE: Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Post-transcriptional gene expression regulation through specific protein-RNA interactions, or RNA-regulatory networks, is critical for expanding the complexity of the mammalian nervous system with implications in an expanding list of neuronal disorders. The proposed studies investigate alternative splicing regulation in generating the distinct molecular programs in diverse neuronal cell types of mouse cortex. Information obtained in the project will provide insights into the fundamental mechanisms that controls such diversity as well as the functional consequences in defined, clinically relevant neuronal cell types.

PI_NAMEs: ZHANG, CHAOLIN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Action Potentials;Affect;Alternative Splicing;ANK3 gene;Axon;Behavior;Biological Models;Brain;candidate validation;cell type;Cells;Classification;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Analysis;Data;Data Set;deep learning;deep learning model;Disease;driving force;Electrophysiology (science);Elements;embryonic stem cell;ES Cell Line;excitatory neuron;Exons;Experimental Models;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Glutamates;Goals;Human;in silico;In Vitro;in vivo;in vivo Model;inhibitory neuron;innovation;insight;interdisciplinary approach;Interneurons;Knock-out;machine learning method;Mammals;Medial;Messenger RNA;Methods;Modeling;Molecular;molecular marker;Molecular Profiling;Morphology;Motor Neurons;mouse model;mRNA Precursor;Mus;Mutagenesis;Nervous System;neural circuit;neurodevelopment;neuronal excitability;Neurons;novel;Organ;Population;posttranscriptional;Probability;Process;programs;Property;Protein Family;Protein Isoforms;Proteins;Regulation;Reporter;Research;Resources;Rest;RNA;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Rodent;Role;Sampling;single-cell RNA sequencing;Specific qualifier value;Spinal;statistical and machine learning;stem cell differentiation;Structure;success;System;Taxonomy;Testing;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;Work

PROJECT_TITLE: RNA Regulatory Networks in Neuronal Cell Type Diversity and Function

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: Osteocytes are bone-embedded cells that extend long projections to connect to other cells in bone, which allows them to control bone remodeling and contribute to bone strength. To better understand how osteocytes form and maintain these dendrite-like projections, we will examine gene and protein expression within the projections themselves. Discovery of new mechanisms that control osteocyte dendrites may lead to new therapeutics targeting osteocytes to improve bone strength and reduce fractures.

PI_NAMEs: MAZUR, COURTNEY MARISA (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3' Untranslated Regions;Affinity Chromatography;Aging;Axon;Binding Sites;Biochemical;Biological Assay;Biology;bone;Bone Diseases;bone fragility;bone health;Bone Matrix;Bone remodeling;bone strength;Bone Surface;Brain;cell type;Cells;Cellular biology;Cessation of life;Dendrites;Disease;Disease Progression;fluid flow;Fracture;Future;Gene Expression;Goals;Homeostasis;Immobilization;improved;In Situ;In Situ Hybridization;In Vitro;in vivo;Individual;innovation;Intercellular Fluid;Learning;Length;macromolecule;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mechanics;Messenger RNA;Modeling;Molecular;Monitor;mRNA Translation;Mus;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Nucleotides;Osteoblasts;Osteoclasts;Osteocytes;paracrine;Pattern;Play;Positioning Attribute;protein expression;Protein Subunits;Proteins;Proteome;Puromycin;Regulation;Reporter;Research;response;Ribosomes;RNA;RNA-Binding Proteins;Role;Signal Transduction;Site;skills;Techniques;Testing;trafficking;training opportunity;Transcript;transcriptome;Translating;Translations;Work

PROJECT_TITLE: Trafficking and translation of mRNA in osteocyte dendrites


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Alzheimer’s disease (AD) is the most prominent neurodegenerative disorder, affecting approximately 40 million people worldwide; and AD is projected to drastically increase in prevalence over the next few decades. The current proposal aims to understand the early molecular basis of AD by determining the underlying mechanisms of impairment in synaptic protein degradation. These studies may reveal proteins or pathways that are critical to AD etiology or early pathology, and subsequently could be targeted to prevent or halt the progression of this debilitating disease.

PI_NAMEs: RAO, NALINI  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;amyloid precursor protein processing;Animals;anti-epileptic agents;Antibodies;Axon;biochemical tools;Biological Assay;Brain;clinically relevant;Critical Pathways;Dementia;diagnostic tool;Disease;Endocytosis;Endosomes;Etiology;Event;Functional disorder;Goals;Human;hyperphosphorylated tau;Impairment;In Vitro;in vitro Model;in vivo;Knock-in;Knock-in Mouse;Label;Lead;Levetiracetam;Mass Spectrum Analysis;Measures;Metabolic;Microfluidic Microchips;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Neurodegenerative Disorders;Neurofibrillary Tangles;neuronal cell body;Neurons;neuropathology;novel;overexpression;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptides;Persons;Phenotype;Physiologic pulse;Play;Pre-Clinical Model;Presynaptic Terminals;Prevalence;prevent;Process;Production;protein aggregation;protein degradation;protein misfolding;protein transport;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Reporter;Research;Role;Site;small molecule;stable isotope;Synapses;Synaptic Vesicles;System;tau Proteins;Techniques;Testing;Therapeutic;Tissues;tool;Ubiquitin;Ubiquitination;uptake;vesicle transport;Work

PROJECT_TITLE: Elucidating the contribution of amyloidogenic APP processing to AD-relevant impaired synaptic protein turnover


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Although molecular targeted therapy has dramatically changed how we treat cancer, the treatment for acute myeloid leukemia (AML) remains focused on the use of cytotoxic drugs with many patients eventually relapsing with their disease. Our studies have uncovered that the MUSASHI (MSI) family is required in AML. This proposal studies this family in both mouse models and in human AML in order to identify novel strategies for targeting the stem cell program in leukemia.

PI_NAMEs: KHARAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3' Untranslated Regions;Acute Myelocytic Leukemia;Address;Advanced Malignant Neoplasm;Arginine;Binding;Binding Proteins;Binding Sites;Blood;Blood Cells;CD34 gene;Cell fusion;cell growth;Cells;chemotherapy;Clinical;Communication;CRISPR screen;Cytotoxic agent;Data;Dependence;Development;Disease;Enzymes;Epigenetic Process;epigenome;Equilibrium;Exhibits;Family;Family member;Family Study;Frequencies;Genetic Models;genome-wide;Hematologic Neoplasms;Hematopoietic stem cells;Human;inhibitor;Knockout Mice;Laboratories;leukemia;leukemia/lymphoma;Leukemic Cell;leukemic stem cell;leukemogenesis;Link;Lymphoma cell;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Mediating;Medicine;Messenger RNA;Methylation;Molecular;molecular targeted therapies;mouse model;Mus;Mutation;Myeloid Leukemia;myeloid leukemia cell;Nature;Normal Cell;novel;novel strategies;novel therapeutic intervention;Outcome;Pathogenesis;Pathway interactions;Patients;Post-Translational Protein Processing;Prognostic Marker;programs;protein function;Proteins;Reagent;Regulation;Relapse;Resistance;response;RNA Binding;RNA Editing;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Site;Solid Neoplasm;stem;stem cell biology;stem cell function;stem cells;synergism;System;Therapeutic;therapeutic target;Time;transcriptome sequencing;Transferase;Translations

PROJECT_TITLE: Characterizing the MSI2 network in leukemia

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Glioblastoma ranks among the deadliest of all human cancers, with current therapies never leading to a cure. In this research project, we will study a novel regulation of brain tumor cells that adopt features of stem cells and are often resistant to brain tumor therapies. The normal responses to the day-night cycle (called the circadian rhythm) have been repurposed by these brain tumor stem-like cells, empowering the design of potential new treatments for patients afflicted with glioblastoma.

PI_NAMEs: KAY, STEVE A;RICH, JEREMY N (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Adjuvant;Adopted;Age;Agonist;angiogenesis;Angiogenic Factor;Apoptosis;ARNTL gene;Attenuated;Binding;Biological Clocks;Brain;Brain Neoplasms;cancer stem cell;Carbon;Caring;Cell Cycle Arrest;cell growth;Cell Maintenance;Cells;Cellular Metabolic Process;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Chromatin;chromatin immunoprecipitation;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Citric Acid Cycle;Clinical;clinically significant;Combined Modality Therapy;Complex;conventional therapy;cryptochrome;Cytolysis;Data;Dependence;design;Development;DNA Damage;Down-Regulation;effective therapy;empowerment;Enzymes;epigenetic regulation;Evolution;Excision;Exposure to;Feedback;Foundations;Genes;Genetic Transcription;Glioblastoma;Glioma;Glucose;Hour;Human;Immune;improved;In Vitro;Invaded;Ionizing radiation;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;neoplastic cell;nerve stem cell;Neurons;new therapeutic target;Normal Cell;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Oral;Organism;palliation;Pathway interactions;patient response;patient stratification;Patients;Performance Status;Planet Earth;Planets;pre-clinical;Process;Prognosis;Proteins;radiation resistance;Radiation therapy;Recurrence;Regulation;Regulatory Pathway;Reporting;Research Project Grants;Resistance;Respiration;response;Role;Rotation;self-renewal;Signal Transduction Pathway;small hairpin RNA;small molecule;small molecule inhibitor;stem;stem cell biology;stem cell growth;stem cell proliferation;stem cell self renewal;stem cells;stem-like cell;stemness;synergism;targeted agent;temozolomide;Testing;therapeutically effective;therapy resistant;Toxic effect;transcription factor;Translating;Treatment Failure;treatment response;Tricarboxylic Acids;tumor

PROJECT_TITLE: Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Patient Safety;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

PHR: PROJECT NARRATIVE Despite great progress in HIV prevention and treatment, many questions remain to be addressed. The Columbia Collaborative HIV/AIDS Clinical Trials Unit is located in a hot spot of HIV activity and is perfectly positioned to conduct cutting edge clinical trials and contribute to scientific agendas of the DAIDS-sponsored Clinical Trials Networks.

PI_NAMEs: SOBIESZCZYK, MAGDALENA ELZBIETA (contact)

PROGRAM_OFFICER_NAME: ROBY, GREGG A,

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Antibodies;Area;Behavioral;biobehavior;Clinical;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communication;Communities;community advisory board;community engagement;Community Health Education;comorbidity;Conduct Clinical Trials;data management;Dedications;Disease remission;Ensure;Epidemic;Evaluation;experience;Formulation;Goals;high standard;HIV;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;Hot Spot;improved;Infrastructure;innovation;Institution;Intervention;Laboratories;Mentors;neutralizing monoclonal antibodies;New York City;next generation;novel;operation;outreach;Passive Immunization;Performance;Pharmacy facility;Physicians;Population;Positioning Attribute;Productivity;Protocols documentation;recruit;Research;Research Personnel;Research Priority;research study;Resource Sharing;Resources;Risk Reduction;Scientist;Social Behavior;Special Event;Structure;success;Therapeutic;Training;Treatment Failure;Tuberculosis;Vaccines


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Orphan Drug;Prevention;Rare Diseases;Substance Misuse;Tuberculosis;Vaccine Related;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The studies proposed in this application will have a direct beneficial effect on the health of millions of people worldwide who are living with or at risk for HIV, tuberculosis and hepatitis B, transforming the health of people with these infections. The clinical research conducted by the UCLA AIDS Prevention and Treatment Clinical Trials Unit will lead to significantly reducing morbidity and mortality, particularly among populations disproportionately affected by HIV/AIDS.

PI_NAMEs: CURRIER, JUDITH S. (contact);LANDOVITZ, RAPHAEL J

PROGRAM_OFFICER_NAME: LANDIS, JESSICA R

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Affect;Age;age group;AIDS prevention;Area;Argentina;Brazil;California;career;Clinic;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Unit;clinically relevant;Collaborations;collaborative approach;community advisory board;community involvement;Community Outreach;comorbidity;Conduct Clinical Trials;design;Development;Doctor of Medicine;Doctor of Philosophy;Education;Enrollment;Ethnic Origin;experience;Goals;Health;Hepatitis B;HIV;HIV Infections;HIV vaccine;HIV/AIDS;improved;Infant;Infection;Interdisciplinary Study;Laboratories;Leadership;Los Angeles;Managed Care;Medical center;Medicine;Mental Health;Mentors;Mentorship;metropolitan;Minority;Morbidity - disease rate;mortality;multidisciplinary;novel strategies;novel vaccines;older adult;pediatric human immunodeficiency virus;Persons;Phase;Population;Population Heterogeneity;Postpartum Women;Pregnant Women;prevent;Prevention;prevention clinical trial;Prevention strategy;Prevention trial;Race;recruit;Research;Research Personnel;Research Priority;Resource Sharing;Risk;Sexual and Gender Minorities;Site;South America;Specimen Handling;substance user;Therapeutic;Therapeutic Trials;transgender;Tuberculosis;Urban Population;vaccine strategy;Woman;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative This study is to use mouse models and human iPSC-derived neurons to test the hypothesis that Alzheimer’s disease (AD) brains have transcriptional downregulation of synaptic genes at the early stage, which initiates the loss of synaptic function in selective neuronal circuitry, leading to cognitive decline. Results gained from this project will offer insights into the design of novel therapy to mitigate cognitive deficits.

PI_NAMEs: FENG, JIAN ;YAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Action Potentials;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Anesthesia procedures;Animals;Autopsy;basal forebrain cholinergic neurons;Behavior;Bioinformatics;Biological Process;Brain;Clinical;Cognition;Cognitive;Cognitive deficits;Complex;Data;design;Down-Regulation;Early identification;Electrophysiology (science);Elements;Functional disorder;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic;Genetic Transcription;Glutamates;Hippocampus;Human;human disease;Impaired cognition;improved;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Intervention;Link;Maps;Molecular;Molecular Target;mouse model;Nerve Degeneration;neural circuit;Neural Pathways;Neurodegenerative Disorders;neuron loss;neuronal circuitry;Neuronal Differentiation;Neurons;neuropathology;Neuropil;novel strategies;novel therapeutics;optogenetics;Output;patch clamp;Pathologic;Pathology;Pathway interactions;Patients;Performance;Physiological;Play;postsynaptic;Prefrontal Cortex;Preparation;presynaptic;Proteins;Research;Resolution;Role;Sampling;selective expression;single-cell RNA sequencing;Slice;spatial memory;Spike Potential;Symptoms;Synapses;synaptic function;Synaptic Transmission;Testing;Therapeutic;therapy design;Tissues;transcriptomics;transmission process;vesicular release;Viral;Virus

PROJECT_TITLE: Transcriptomic and Circuitry Aberrations in Alzheimer’s Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE UBE3A is a gene that is linked to a number of neuropsychiatric conditions such as Angelman syndrome, Dup15q syndrome, bipolar disorder, depression, and schizophrenia. Our studies will lead to a better understanding of the contribution of UBE3A to disease and provide novel insights for therapeutic intervention for a variety of neuropsychiatric disorders.

PI_NAMEs: YI, JASON J (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Angelman Syndrome;Animals;Benign;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Bipolar Disorder;Calorimetry;Catalogs;Cells;chromosome 15q duplication syndrome;Cryoelectron Microscopy;developmental disease;Disease;Dose;Engineering;enzyme mechanism;Enzymes;experimental study;gain of function;gain of function mutation;Genes;Goals;high throughput screening;Hyperactivity;in vivo;Individual;insight;interest;Kinetics;Length;Link;Literature;loss of function;loss of function mutation;Measures;Mental Depression;Mental disorders;Methods;Modeling;Mood Disorders;Mus;Mutation;neuron development;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;Pathology;Phenotype;Protein Engineering;Proteins;public health relevance;Regulation;Regulatory Element;Reporting;Research;Schizophrenia;Site;Structure;Synapses;Testing;Therapeutic Intervention;Titrations;tool;UBE3A gene;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: Understanding the mechanisms of UBE3A regulation in neuronal development

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: As gene mutations found in cancers that spread to other organs (i.e., metastasis) are not too much different from those found in primary tumors from the same patients, scientists have proposed that non-genetic heritable mechanisms referred to as epigenetic mechanisms may be the “real” driver for metastasis. The purpose of this project is to study how loss of LSD1, an epigenetic regulator, contributes to increased breast cancer metastasis, by both cell-intrinsic (i.e., via its regulation of key target genes in breast epithelial cells) and extrinsic (e.g., immune cell-related) mechanisms. The knowledge from this project may translate into novel therapeutic targets and strategies to treat and/or prevent the metastatic disease.

PI_NAMEs: LI, ZHE  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Ablation;Address;Adhesions;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Epithelial Cells;cancer genome;cancer initiation;cancer type;CDH1 gene;Cell Adhesion;Cell Cycle;Cell Differentiation process;cell type;Cell-Cell Adhesion;Cells;Cessation of life;Complex;CRISPR screen;Data;Deletion Mutation;Development;Disease;DNA Sequence Alteration;driver mutation;Endogenous Retroviruses;Epigenetic Process;epigenetic regulation;Estrogen receptor positive;Estrogen Receptors;Exhibits;EZH2 gene;Failure;GATA3 gene;Gene Mutation;gene repression;Genes;genetic approach;Genetic Models;Genetic study;Genetic Transcription;Genome;genome sequencing;Genomics;Heritability;histone demethylase;Histone H2A;Histones;Human;Immune;Immune response;Impairment;in vivo;inhibitor;Injections;Invaded;KDM1A gene;KLRD1 gene;Knowledge;Ligands;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;Mediator;Metastasis Suppression;Metastatic breast cancer;Metastatic Neoplasm to the Lung;methyl group;migration;Modeling;Molecular;Molecular Abnormality;Monoubiquitination;mortality;Mouse Mammary Tumor Virus;mouse model;Mus;Mutation;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;non-genetic;novel strategies;Oncogenic;Oncoproteins;Organ;Pathway interactions;Patients;Play;Point Mutation;Polycomb;polyoma middle tumor antigen;prevent;Primary Neoplasm;programs;Proliferating;protein complex;Qa-1 Antigen;receptor;Regulation;Repression;Role;Scientist;Specificity;System;targeted treatment;Testing;The Cancer Genome Atlas;transcription factor;Translating;transplant model;tumor microenvironment;tumor-immune system interactions;ubiquitin ligase;Up-Regulation;Work

PROJECT_TITLE: Mechanism of LSD1 in breast cancer metastasis suppression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: ASOCIACION CIVIL IMPACTA SALUD Y EDUCACN

PHR: Project Narrative The PERU CTU proposes to continue contributing to the design and implementation of the DAIDS scientific research agenda to decrease new HIV infections, reduce HIV associated morbility and mortality, and ultimately end the HIV epidemic. Given the high incidence of tuberculosis in the country and the high burden of drug resistant strains, the PERU CTU is in an advantageous position to continue contributing to the design and implementation of clinical trials evaluating interventions to control the tuberculosis epidemic. Our strategy is to focus on vulnerable populations in resource limited settings, utilizing existing research infrastructure that includes state of the art laboratories, experienced personnel, with active participation from community stakeholders.

PI_NAMEs: LA ROSA, ALBERTO ;SANCHEZ, JORGE LUIS (contact)

PROGRAM_OFFICER_NAME: GUERRA, MARIA ISABEL

PROJECT_TERMS: 3-Dimensional;Address;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Antibodies;Area;Caring;Clinical;clinical practice;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;Combined Vaccines;Communication;Communities;community advisory board;community engagement;Community Participation;comorbidity;Conduct Clinical Trials;Cost Control;Country;design;Disease;Drug Interactions;Drug resistance;Drug resistance in tuberculosis;Ensure;Epidemic;Ethics;experience;flexibility;Formulation;Funding;Future;Generations;Goals;Grant;high standard;HIV;HIV Infections;HIV prevention trial;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;HIV/TB;Human Resources;implementation intervention;improved;Incidence;Individual;Infrastructure;innovation;Intervention;Investments;Laboratories;member;men who have sex with men;Meningeal Tuberculosis;Morbidity - disease rate;mortality;novel;novel therapeutic intervention;operation;organizational structure;Peru;Peruvian;Pharmaceutical Preparations;Phase;Positioning Attribute;pre-exposure prophylaxis;Predisposition;prevent;Prevention;preventive intervention;Principal Investigator;Production;Protocols documentation;Publications;Recurrence;Research;Research Infrastructure;Research Personnel;Research Priority;research study;resistant strain;Resource-limited setting;Resources;response;Safety;Services;System;Testing;tool;Toxic effect;transgender women;treatment optimization;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;vaccine candidate;vaccine evaluation;vaccine trial;Vaccines;Vulnerable Populations

PROJECT_TITLE: PERU Clinical Trial Unit


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

PHR: We propose to make the first attempt to comprehensively describe and understand how neurons in the mammalian hippocampus are selected and recruited to encode memories. We will use cutting-edge high- resolution recording technologies to study and manipulate identified cell types in behaving animals. We will combine experiments with a tractable, biophysical circuit model of the hippocampal area to explain how observations may underlie memory formation. These powerful new approaches are likely to yield major insights into the principles by which the individual neurons and their interactions give rise to cognitive function, with important implications for memory disorders.

PI_NAMEs: LOSONCZY, ATTILA  (contact);POIRAZI, PANAYIOTA

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TITLE: Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representations

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The precise assembly of neuronal connections during development is critical for the nervous system to accurately encode information necessary for complex behavior and any disruption of this intricate process can lead to a wide range of neurodevelopmental and neuropsychiatric disorders. This proposal focuses on the molecular mechanisms underlying circuit-wide axonal target selection during neural circuit formation and, thus, could be an integral part of generating therapeutic strategies for neurological conditions with developmental origins. Additionally, this study may elucidate mechanisms relevant to understanding and treatment of circuit degeneration resulting from age, injury, or disease.

PI_NAMEs: GINGRICH, ELLEN  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Age;alpha-latrotoxin receptor;Anatomy;Axon;axon guidance;Behavior;Brain;career development;Cell Nucleus;Cell surface;Central Nervous System;Code;collaborative environment;Complex;Development;Disease;Distal;Distant;entorhinal cortex;Fellowship;Gene Order;Genes;Genetic;genetic approach;Goals;Hippocampus;Hypothalamic structure;In Vitro;Individual;Injury;knockout animal;Lateral;Ligands;loss of function;Medial;Mediating;Mediator;Mental disorders;Mentorship;Messenger RNA;Mission;Molecular;Mus;National Institute of Mental Health;Nervous System;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurologic;Neurons;neuropsychiatric disorder;postnatal;Process;Proteins;receptor;Regional Anatomy;Research;Role;segregation;Series;Signal Transduction;Specific qualifier value;Specificity;Stereotyping;Synapses;synaptogenesis;Technical Expertise;Techniques;Testing;Thalamic structure;Therapeutic;Training;Universities;Viral;virus genetics;Writing

PROJECT_TITLE: Teneurin-3 and Latrophilin-2 in circuit-wide topographic target selection of the extended hippocampal network


ORG_DEPT: GENETICS

PHR: Project Narrative Genome instability is a near ubiquitous characteristic of human cancer and is associated with worse patient outcomes, but when and how it arises in tumor development is not completely understood. The proposed work aims to uncover the role of the recently discovered cis-acting ASAR long non-coding RNA elements (ASynchronously Replicating Autosomal RNA) in the maintenance of normal chromosome stability, and the potentially widespread effects of ASAR disruption in cancer. The results of this proposal will contribute to a better fundamental understanding of how chromosomes function in normal and cancer cells, and ultimately help to fill the desperate need for new diagnostic and therapeutic options targeting unstable genomes in human cancer.

PI_NAMEs: HESKETT, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;articular cartilage;autosome;Behavior;Bioinformatics;Biological Assay;Biological Models;Biology;Biometry;cancer cell;Cancer Diagnostics;cancer genome;Cancer Model;cancer risk;cancer type;Cell Line;Cell model;Cells;Chromatin;Chromatin Structure;Chromosomal Loss;Chromosomal Rearrangement;Chromosomal Stability;Chromosome 15;Chromosome 6;Chromosome abnormality;Chromosome Condensation;chromosome conformation capture;Chromosome Deletion;chromosome missegregation;chromosome replication;Chromosome Structures;Chromosomes;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Data Set;Development;DNA analysis;DNA biosynthesis;DNA replication fork;DNA Replication Timing;Elements;Event;Family;Fluorescent in Situ Hybridization;Future;Gene Expression;Genes;Genetic Nondisjunction;Genetic Transcription;Genome;Genome Stability;genome wide association study;genome-wide;Genomic Instability;Genomics;Germ Lines;Haplotypes;Health;Human;Human Characteristics;Human Chromosomes;In Vitro;insight;interest;Knowledge;Laboratory Finding;Lead;Learning;Link;lymphoblastoid cell line;Maintenance;Malignant Neoplasms;Measures;Medical;member;Methods;micronucleus;Mitotic;Mitotic Chromosome;Modeling;Molecular;Names;Normal Cell;novel diagnostics;novel therapeutic intervention;novel therapeutics;Nucleotides;Operative Surgical Procedures;Patient-Focused Outcomes;Phase;Phenotype;Physical condensation;Population;Postdoctoral Fellow;pre-doctoral;progenitor;Prognosis;programs;Progress Reports;Proteins;Public Speaking;Research;risk variant;RNA;Role;Route;Sampling;Single Nucleotide Polymorphism;skill acquisition;skills;stem cells;targeted cancer therapy;Testing;The Cancer Genome Atlas;Tissues;tool;Training;Transcript;Translating;tumor;tumor progression;Untranslated RNA;virtual;Visualization;Work

PROJECT_TITLE: Integrative Analysis of DNA Replication Timing in Cancer


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: The Alabama to Zambia Clinical Trials Unit (A-to-Z CTU) is dedicated to advancing science to improve the quality and longevity of lives of people living with HIV (PLWH), ending the HIV epidemic, and eliminating disparities for PLWH. Our two Clinical Research Sites are geographically located in Alabama, where the US HIV epidemic is ongoing, and Zambia, where the global burden of HIV is greatest. Our integrated leadership group and staff will leverage our long-standing experience in clinical trials to contribute to the global efforts to end the HIV epidemic.

PI_NAMEs: GOEPFERT, PAUL A. (contact)

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;AIDS clinical trial group;Alabama;Caring;Clinical Management;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communication;community engagement;comorbidity;Creativeness;Data;data management;Dedications;Development;disparity elimination;Eligibility Determination;Enrollment;Ensure;Epidemic;expectation;experience;Faculty;Female;flexibility;Foundations;Funding;Geographic Locations;Hepatitis B;HIV;HIV Infections;HIV Vaccine Trials Network;HIV/AIDS;improved;Incidence;Infectious Diseases Research;Institution;International;laboratory facility;Laboratory Research;Leadership;Longevity;Medicine;member;Mentors;Minority;multidisciplinary;Names;National Institute of Allergy and Infectious Disease;Network-based;Participant;participant retention;Performance;Persons;Pharmacy facility;Population;Populations at Risk;Prevention trial;Problem Solving;Procedures;Protocols documentation;Publications;Readiness;Research;Research Infrastructure;Research Methodology;Research Personnel;Risk;Sampling;scale up;Science;Scientific Advances and Accomplishments;Site;support network;Talents;Tuberculosis;United States National Institutes of Health;Universities;vaccine trial;Zambia

PROJECT_TITLE: A-Z Clinical Trials Unit


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The success of brain tumor resection and biopsy is limited by the surgeon's ability to distinguish pathologic from normal tissue intraoperatively and in real-time. Our novel optical imaging FLIm system captures and analyzes tissue autofluorescence to identify distinct brain tissue types (tumor, necrotic, normal) and integrates this information with standard of care neurosurgical technologies for convenient display onto the surgeon's field-of- view, providing a means to better acquire a robust diagnostic biopsy and achieve maximal tumor resection. The successful validation of FLIm as an intraoperative adjunct for tumor tissue identification will improve brain cancer patient outcomes and generate a paradigm for the use of FLIm in multiple areas of surgical oncology (other cancers) as well as guided interventions for treatment of functional neurologic diseases.

PI_NAMEs: BLOCH, ORIN ;MARCU, LAURA  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Affect;Area;Biochemical;Biometry;Biopsy;Brain;brain abnormalities;Brain Neoplasms;brain tissue;brain tumor resection;Cauterize;Characteristics;Classification;Clinical;Clinical Research;Clinical Trials;cohort;Complement;Complex;Comprehensive Cancer Center;Conventional Surgery;Craniotomy;Data;data acquisition;Data Display;Databases;Diagnostic;Diagnostic Imaging;Diagnostic Procedure;diagnostic value;Discrimination;Engineering;Environment;Epilepsy;Equipment;Excision;feature detection;flexibility;Fluorescence;fluorescence lifetime imaging;Glioma;Goals;Harvest;Hemostatic function;Histopathology;Human;Image;image processing;Image-Guided Surgery;Imaging Device;imaging system;Imaging Techniques;Imaging technology;improved;instrumentation;Intervention;Label;learning progression;Letters;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Manufacturer;Measurement;Metabolic;Microscope;multidisciplinary;Necrosis;Neoplasm Metastasis;Nervous System Disorder;neuro-oncology;Neurodegenerative Disorders;Neurologic;Neuronavigation;neuropathology;Neurosurgeon;neurosurgery;Neurosurgical Procedures;Normal tissue morphology;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;Pathologic;Pathology;Patient-Focused Outcomes;Patients;pragmatic implementation;Predictive Value;Procedures;Property;prospective;Protocols documentation;Qi;Radiation necrosis;real-time images;Resources;Scanning;Signal Transduction;Specimen;standard of care;success;Surgeon;Surgical Oncology;Surgically-Created Resection Cavity;System;Techniques;Technology;temporal measurement;Testing;Time;Tissue Sample;Tissues;tool;tumor;Tumor Tissue;Validation;Visual;Visualization

PROJECT_TITLE: Label-free fluorescence lifetime imaging for intraoperative real-time guidance of neurological procedures

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rare Diseases;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Selective estrogen receptors modulators (SERM) have been shown to be neuroprotective, but their efficacy in neurodegenerative diseases has not been fully understood and tested. This application focuses on the ability of the SERM raloxifene to activate both the proteasome activity and mitochondrial genes and delay disease progression in mouse models of amyotrophic lateral sclerosis.

PI_NAMEs: GERMAIN, DORIS A (contact);MANFREDI, GIOVANNI

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Affect;American;Amyotrophic Lateral Sclerosis;Binding Sites;Brain;Breast Cancer Prevention;Central Nervous System;ChIP-seq;Chronic;Clinical;Complex;Cytosol;Data;Defect;Deubiquitinating Enzyme;Disease;Disease Progression;DNA Binding;Dose;effective therapy;ESR1 gene;Estrogen Therapy;Estrogens;familial amyotrophic lateral sclerosis;FDA approved;Female;frontotemporal lobar dementia amyotrophic lateral sclerosis;gender disparity;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Homeostasis;Human;improved;improved outcome;Intervention;male;misfolded protein;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;mutant mouse model;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroprotection;Onset of illness;Osteoporosis prevention;Pathway interactions;Patients;Phase;Predisposition;programs;Proteasome Inhibition;protective effect;protein aggregation;Proteins;proteostasis;proteotoxicity;Raloxifene;Regimen;response;Selective Estrogen Receptor Modulators;Serum;sex;sex disparity;sexual dimorphism;sexual disparity;Source;Specificity;Spinal Cord;Stress;superoxide dismutase 1;Symptoms;synergism;Tamoxifen;Testing;Tissues;transcriptome sequencing;ubiquilin;Ubiquitin;ubiquitin isopeptidase;Work

PROJECT_TITLE: Raloxifene-Based Therapy in Neuro Degenerative Diseases

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences

PHR: Project Narrative Neurosurgical treatment of epilepsy often fails, and neurostimulation to treat epilepsy remains suboptimal and ad hoc. Identification of an improved biomarker - to target epilepsy treatment and assess treatment efficacy - is required. This project combines clinical data from human patients, experiments in animal models, and computer simulations of brain activity to develop an improved biomarker for epilepsy treatment, and to develop a deeper understanding of the mechanisms driving the pathological brain dynamics in epilepsy.

PI_NAMEs: CHU, CATHERINE J (contact);EDEN, URI TZVI;KRAMER, MARK ALAN;RICHARDSON, ROBERT MARK

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Action Potentials;Address;Affect;Animal Experiments;Animal Model;Automobile Driving;Biological;Biological Markers;Brain;Brain Diseases;Brain region;candidate identification;Caring;Clinical;Clinical Data;clinical practice;Computer Models;Computer Simulation;Consumption;detector;Diffuse;Disabling;effective therapy;Electric Stimulation;Epilepsy;epileptiform;Event;Excision;excitatory neuron;experimental study;Failure;Generations;High Frequency Oscillation;Human;human data;Image;imaging approach;Imaging Techniques;improved;in silico;in vivo;Individual;inhibitory neuron;Institution;Intervention;Intractable Epilepsy;large datasets;Machine Learning;Medical;Methods;Modeling;models and simulation;Modernization;Monitor;mouse model;Neurons;neurophysiology;neuroregulation;neurosurgery;novel;Operative Surgical Procedures;Optics;Pathologic;Pathologic Processes;Patient Care;Patients;Pattern;Persons;Pharmaceutical Preparations;Physiological;Physiological Processes;prevent;Protocols documentation;Recurrence;Refractory;Reproducibility;Research;Resected;Seizures;Signal Transduction;Specificity;statistics;successful intervention;surgery outcome;Testing;Time;Tissues;Treatment Efficacy;voltage

PROJECT_TITLE: Targeting Pathologic Spike-Ripples to Isolate and Disrupt Epileptic Dynamics

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Diabetes;Maternal Health;Pregnancy;Women's Health Research

PHR: Project Narrative In this proposal, we will determine the role of Nrf2 in beta cell proliferation, function, and survival during pregnancy, and thus its role to maintain appropriate physiological beta cell mass. These studies are directly relevant to the many millions of gestational diabetes mellitus patients worldwide who will benefit from the knowledge generated, which may lead to the development of novel therapeutic strategies to treat this disease.

PI_NAMEs: ALTERZON, SHARON  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;advanced maternal age;adverse outcome;Affect;Apoptosis;Beta Cell;Biology;Blood Glucose;blood glucose regulation;capsule;Cell Physiology;Cell Proliferation;Cell Survival;ChIP-seq;Data;Data Set;Defect;design;Development;developmental disease;Diabetes Mellitus;Disease;Family history of;Female;fetal;Fetus;Future;Gene Modified;Genes;genome wide association study;Gestational Diabetes;Glucose;glucose tolerance;Goals;Human;Hyperlipidemia;Hypertension;Impairment;improved;in vivo;insight;Insulin;Insulin Resistance;insulin secretion;islet;Kidney;Knowledge;Knowledge acquisition;loss of function;Maps;maternal risk;Measures;Mediating;Methodology;Modeling;Mothers;Mus;Mutation;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;Overnutrition;Pathway interactions;Patients;Physiological;Polycystic Ovary Syndrome;post pregnancy;Postpartum Period;Pregnancy;pregnant;Prevalence;Proliferating;protective effect;Race;Reporting;Research Personnel;response;Risk Factors;Role;skills;Surveys;Testing;Therapeutic;therapeutic target;Time;transcriptome sequencing;Transplantation;treatment strategy;type I diabetic;Writing

PROJECT_TITLE: The role of Nrf2 in beta cell expansion during pregnancy


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Early life adversity increases the risk of future morbidity and mortality due to cardiovascular disease. This project takes advantage of a large, well-characterized, prospective cohort of youth who were recently investigated for child maltreatment and comparison youth without a maltreatment history to better understand the physiological mechanisms between early adversity and cardiovascular disease risk. By taking advantage of detailed assessments of immune function coupled with administrative health care records and thorough behavioral and psychosocial assessments, we will prospectively examine links between child maltreatment and cardiovascular disease risk, with the hopes of informing future prevention and intervention efforts.

PI_NAMEs: SCHREIER, HANNAH MILENA CAROLINE (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Adult;Adverse effects;Age;aged;aging related disease;Anti-Inflammatory Agents;Behavior assessment;Biological;Biological Markers;biopsychosocial;Blood Pressure;boys;C-reactive protein;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;case control;Cessation of life;Characteristics;Child Abuse and Neglect;Child Health;Childhood;Chronic;Chronic Disease;Chronic stress;cohort;cost;Coupled;cytokine;Data;Development;Diagnosis;disorder risk;early adolescence;early life adversity;early life stress;Environment;Ethnic Origin;experience;Exposure to;Family;Funding;Future;Gender;girls;Glucocorticoids;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health Care Costs;health care service utilization;health difference;health disparity;health record;Healthcare;High Density Lipoprotein Cholesterol;high risk;immune function;immune health;Immune response;Immunologics;improved;In Vitro;Inflammation;Inflammatory;insight;Insulin;Interdisciplinary Study;Intervention;Investigation;late life;Leukocytes;Life;Life Style;Link;Literature;Longitudinal cohort;Low-Density Lipoproteins;maltreatment;Measures;Medicaid;microbial;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neglect;novel;Obesity;Outcome;Participant;Pathway interactions;peer;Personal Satisfaction;personalized intervention;Phenotype;physical abuse;Physiological;Play;Population;Prevention;primary caregiver;Procedures;Process;Production;Productivity;prospective;Prospective cohort;Prospective Studies;protective factors;psychologic;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Puberty;Public Health;Race;Recording of previous events;Records;recruit;Regulation;Research;response;Rest;Risk;Risk Reduction;Role;Sampling;Services;Severities;Sexual abuse;Signal Transduction;sociodemographics;Stress;stressor;Survivors;Testing;Time;Triglycerides;Universities;Virus Latency;Vulnerable Populations;Well in self;Youth

PROJECT_TITLE: Child maltreatment and cardiovascular disease risk: examining psychosocial and immunological pathways in a prospective, longitudinal cohort

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Neurologists need to know the molecular basis of disease in order to help find ways to treat patients. We propose to develop and harness new technologies to identify RNA differences that predict how to target brain disease. The strategy combines new single cell methods, computational science and a focused approach to treatment to identify druggable targets by cell type and subcellular localization.

PI_NAMEs: DARNELL, ROBERT B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Affect;Astrocytes;Basic Science;Big Data;Biological Models;Brain;Brain Diseases;cell type;Cells;Computational Science;Data Analyses;Defect;Disease;DNA;druggable target;Etiology;Genetic;Goals;Health;Human;Individual;Informatics;Knowledge;Mediating;Methods;Microglia;Modernization;Molecular;Molecular Biology;Nervous System Disorder;Neurologist;Neurons;Neurosciences;new technology;Patients;Protein Isoforms;Proteins;receptor;Regulation;RNA;Science;stoichiometry;success;targeted treatment;Technology;therapeutic target

PROJECT_TITLE: Combining New Molecular and Informatic Strategies to Find Hidden Ways to Treat Brain Disease


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Post-Traumatic Stress Disorder (PTSD);Precision Medicine

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PTSD can occur after a direct or indirect traumatic experience and is a highly prevalent and debilitating disorder. This research project use a big data and data-driven approaches to study the heterogenity of PTSD. In the long term, this line of research will aid in finding neural biomarkers of PTSD and better predict different treatment outcomes through different biotype targets, which will advance the development of effective diagnostics and treatments for PTSD.

PI_NAMEs: ZHU, XI  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;advanced analytics;Advanced Development;Anxiety;Anxiety Disorders;anxiety-related disorders;associated symptom;authority;Behavioral;Big Data;Biological;Biological Markers;biomarker identification;biotypes;Brain;Brain imaging;Categories;Classification;Clinical;clinical heterogeneity;clinical phenotype;Clinical Treatment;Clinical Trials;Cluster Analysis;comorbidity;Complex;Data;data fusion;Data Set;Dependence;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;DSM-IV;Ensure;Environment;experience;Fostering;Fright;Functional disorder;Future;Goals;Grant;gray matter;Heterogeneity;Individual;individualized medicine;Knowledge;large datasets;Machine Learning;machine learning model;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;memory process;Mental Depression;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;multimodal fusion;Multimodal Imaging;multimodal neuroimaging;multimodality;National Institute of Mental Health;neural;neurobiological mechanism;Neurobiology;patient oriented;Patients;Pattern;Pattern Recognition;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;predicting response;Prediction of Response to Therapy;Prevalence;programs;Psychiatry;Psychoses;Psychotherapy;Public Health;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Rest;reward processing;Sample Size;Selection for Treatments;Site;skills;Subgroup;supervised learning;Symptoms;Techniques;therapy development;Training;Translational Research;Trauma;trauma exposure;treatment comparison;Treatment outcome;treatment research;treatment response;treatment strategy;unsupervised learning;Work;working group

PROJECT_TITLE: Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) Achieving the long-term goal of greater speech intelligibility in individuals with sensory hearing loss will require detailed knowledge of the deficits in cochlear processing that underlie such perceptual difficulties. The proposed study advances this knowledge by characterizing with direct recordings and modeling studies how the normal and damaged cochlea processes dynamic sounds and how the features of this dynamic processing can be assessed in individuals using noninvasive measurements. Results of the proposed work will help guide the development of new diagnostic tests and treatment strategies (e.g., signal-processing algorithms used in hearing aids) aimed at restoring normal temporal cochlear processing in cases of sensory hearing loss.

PI_NAMEs: CHARAZIAK, KAROLINA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Trauma;Address;Affect;Algorithms;Amplifiers;Animal Model;Animals;Apical;auditory processing;Auditory system;Back;Basilar Membrane;Biological Assay;California;career development;Characteristics;Cochlea;Communities;Compensation;Complex;Data;Data Analyses;Dependence;Development;Diagnosis;Diagnostic tests;Environment;Exhibits;Faculty;Frequencies;Goals;Hearing;Hearing Aids;Hearing Tests;Human;Impairment;improved;in vivo;Individual;insight;Institution;Intervention;Knowledge;Location;mathematical model;Measurable;Measurement;Measures;mechanical properties;Mechanics;Mentors;Modeling;Motion;Motor;mouse model;Mus;mutant;Neurosciences;Non-Invasive Detection;noninvasive diagnosis;Nonlinear Dynamics;novel diagnostics;Optical Coherence Tomography;Organ of Corti;otoacoustic emission;Outer Hair Cell of the Organ of the Corti;Outer Hair Cells;Peripheral;Phase;Positioning Attribute;preservation;Process;public health relevance;Recording of previous events;Research;response;Role;Sensorineural Hearing Loss;Shapes;Signal Transduction;skills;sound;Speech;Speech Intelligibility;Stimulus;Structure;Study models;Surface;System;Testing;Theoretical model;Time;tool;Training;Transgenic Mice;transmission process;treatment strategy;Universities;Work

PROJECT_TITLE: Understanding the dynamics of cochlear amplification


NIH_SPENDING_CATS: Neurosciences

PHR: Our long-term goal is to understand how glia contribute to nervous system development, function, and information processing. We have shown that glia play key roles in regulating neuronal shape and function in the nematode C. elegans. Here we will test the idea that glia are important regulators of synaptic function, and brain assembly, and study a new form of cell death with relevance to the nervous system. Our studies have broad implications for understanding glia-neuron interactions in all animals, including humans.

PI_NAMEs: SHAHAM, SHAI  (contact)

PROJECT_TERMS: Address;Afferent Neurons;Animals;Astrocytes;Biology;Brain;Bypass;Caenorhabditis elegans;Cell Death;Cell Fraction;Complement;Cues;Development;Excitatory Synapse;functional plasticity;gliogenesis;Goals;Hand;Human;in vivo;information processing;Ions;Learning;Molecular;Nematoda;Nerve Degeneration;Nervous System;nervous system development;Neuroglia;Neuromuscular Junction;neuron development;neuronal survival;Neurons;Neurotransmitter Receptor;Neurotransmitters;Organ;Play;programs;Radial;Sense Organs;Sensory;Shapes;Specific qualifier value;Structure;Synapses;synaptic function;System;Testing;transcription factor;Vertebrates

PROJECT_TITLE: Glial Control of Neuron Development and Function


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Primary Health Care;Rehabilitation

PHR: Project Narrative This cancer education training project’s goal is to train healthcare providers (HCPs) to work more effectively with older cancer patients who may have cognitive and functional difficulties. This project is important because it will help prepare the work force to care for the growing numbers of older cancer patients and their families. Results of this study have the potential to improve the knowledge and communication skills of oncology HCPs which will benefit HCPs and older oncology patients and their families.

PI_NAMEs: PARKER, PATRICIA A (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Adherence;Ageism;aging population;aging related disease;American;American Society of Clinical Oncology;Attitude;Awareness;cancer diagnosis;cancer education;Cancer Patient;cancer therapy;care providers;career;Caregivers;Caring;Chronic Disease;Clinical;clinical decision-making;Cognition;Cognitive;cognitive ability;Cognitive deficits;cohort;Communication;Communication difficulty;Communication Programs;Decision Making;design;Development;Diagnosis;Disease;Education;Elderly;Faculty;Family;functional decline;functional disability;Geriatrics;Goals;Health Benefit;Health Personnel;health training;Impaired cognition;Impairment;improved;Individual;Informed Consent;Institute of Medicine (U.S.);interest;International;Knowledge;Learning;Learning Skill;learning strategy;Malignant Neoplasms;Medical;multidisciplinary;multimodality;Nurse Practitioners;Nurses;Occupational Therapist;older adult;older patient;Oncologist;Oncology;Online Systems;Participant;patient engagement;patient oriented;Patients;person centered;Persons;physical therapist;Physician Assistants;Population;Prevention;primary care provider;Process;programs;Recommendation;Research;Science;shared decision making;skill acquisition;skills;Social Workers;Societies;Syndrome;Training;Training Programs;training project;treatment planning;United States;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Geriatric Oncology: Cognition and Communication

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Serious Mental Illness

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Population genomics allows us to map the genetic determinants of human disease, but keeps the underlying molecular mechanisms and pathways hidden. Functional genomics, on the other hand, allow researchers to dissect the molecular machinery of the cell that interprets the instructions hidden in our genome, but does not provide explicit connections to disease. In this project, we develop computational strategies that exploit existing knowledge about molecular networks to achieve mechanistic understanding of how genetic variants impact disease, which can help suggest specific therapeutic directions.

PI_NAMEs: BUSSEMAKER, HARMEN J (contact);LAPPALAINEN, TUULI

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;Affinity;Algorithms;Alleles;Attention;autism spectrum disorder;Binding;Binding Sites;Biology;Bipolar Disorder;Catalogs;cell type;Cells;ChIP-seq;Chromosome Mapping;Clinical;cohort;Complex;Computing Methodologies;CRISPR interference;Cytoplasm;Data;Data Set;Disease;disease phenotype;disorder risk;DNA;DNA Binding;DNA-Protein Interaction;Environment;experimental study;functional genomics;gene expression variation;gene regulatory network;Genes;Genetic;genetic analysis;genetic association;Genetic Determinism;Genetic Diseases;Genetic Polymorphism;Genetic Risk;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype-Tissue Expression Project;Human;human data;human disease;Human Genetics;human tissue;improved;In Vitro;Individual;innovation;Instruction;inter-individual variation;interest;Intervention;Knowledge;Linear Models;Maps;Mediator;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;model organism;Modeling;Molecular;mRNA Expression;Nuclear;Pathway interactions;pharmacologic;Physiological;Population;Post-Translational Protein Processing;promoter;Proteins;Quantitative Genetics;Quantitative Trait Loci;rare variant;rational design;Regulatory Element;Regulon;Research Personnel;Risk;risk variant;Role;Schizophrenia;Therapeutic;Tissue Sample;Tissues;trait;Trans-Omics for Precision Medicine;transcription factor;transcriptome;transcriptome sequencing;Unipolar Depression;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Integrative analysis of genetic variation and transcription factor networks to elucidate mechanisms of mental health disorders

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Migraine is one of the top leading causes of disability worldwide, yet its underlying pathophysiology remains unclear. The proposed research project will interrogate a novel triggering mechanism underlying the headache in migraine without aura, which involves sensory cortex hyperexcitability and related aberrant signaling between cortical astroglia and the sensory neurons that innervate the intracranial meninges, whose activation is thought to drive migraine headache.

PI_NAMEs: LEVY, DAN  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Acute;Address;Adult;afferent nerve;Afferent Neurons;allodynia;Anesthesia procedures;Astrocytes;Attenuated;Auras;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Brain;Calcitonin Gene-Related Peptide;Calcium;cell type;Cephalic;Cerebral meninges;Chronic;Common Migraine;Data;designer receptors exclusively activated by designer drugs;Development;disability;Dura Mater;Electrophysiology (science);extracellular;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genetic;genetic approach;genetic manipulation;Grant;Headache;Image;imaging approach;imaging modality;in vivo;inhibiting antibody;Investigation;Leptomeninges;Link;Mediating;Mediator;Meningeal;Meninges;Methods;Migraine;Monitor;Monoclonal Antibodies;Mus;Nerve Endings;Neurons;Nitroglycerin;Nociception;nociceptive response;Nociceptors;novel;optogenetics;pain behavior;pain sensitivity;Pathogenesis;Pathway interactions;Patients;Peptide Signal Sequences;Peripheral;Play;Population;Process;Property;Rattus;receptor;Research;Research Project Grants;response;Role;Sensory;sensory cortex;sensory system;Signal Pathway;Signal Transduction;Spreading Cortical Depression;Subarachnoid Space;Testing;tool;Trigeminal System;two-photon

PROJECT_TITLE: Cortical-Meningeal Interactions Underlying Migraine Headache

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Cerebrovascular;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Women's Health Research

PHR: Project Narrative Brain metastasis of breast cancer is a devastating progression for women with advanced breast cancer. In the F00 phase of this application we attempt to improve treatment options for women with HER2+ brain metastases of breast cancer by investigating the possibility of efficient timing of targeted chemotherapies following radiation therapy. In the K00 phase I will pursue post-doctoral training with experts in understanding the blood-tumor barrier’s response to radiation therapy at a molecular and cellular level, or evaluate the permeability of the blood-tumor barrier to varying sized tracers following low-intensity focused ultrasound treatment for brain metastases of breast cancer.

PI_NAMEs: SPROWLS, SAMUEL ADAM TYLER (contact)

PROJECT_TERMS: advanced breast cancer;Animal Model;Animals;anti-cancer research;Astrocytes;Award;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;blood-brain tumor barrier;Brain;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Cancer Center;Cancer Etiology;Central Nervous System Neoplasms;chemotherapy;Clinical Data;clinical translation;clinically relevant;Consensus;Coupled;cytotoxic;cytotoxicity;Data;data modalities;Dependence;design;Diagnosis;Dose;Endothelial Cells;Environment;ERBB2 gene;Event;experimental study;Faculty;Failure;Fluorescence;Focused Ultrasound;Focused Ultrasound Therapy;foot;Foot Process;Foundations;Funding;Glioblastoma;Goals;human model;imaging modality;Imaging Techniques;improved;innovation;Institution;Ionizing radiation;Laboratory Research;Lead;Lesion;Magnetic Resonance Imaging;malformation;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mentors;Mentorship;Metastatic malignant neoplasm to brain;Microbubbles;Modeling;Molecular;Monitor;multimodality;Mus;Neoplasm Metastasis;Neurocognitive Deficit;Neuroimmune;neurovascular unit;novel;Operative Surgical Procedures;Outcome;palliative;Patients;Penetration;Pericytes;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;programs;Protocols documentation;Publications;Radiation;radiation effect;Radiation exposure;radiation response;Radiation therapy;Regulation;Reporting;Research;Research Personnel;Research Project Grants;response;Science;Sex Differences;standard care;Techniques;Testing;Therapeutic;Time;Tracer;Training;treatment strategy;tumor;Universities;West Virginia;Woman;Women's mortality;Work

PROJECT_TITLE: Sex Differences in Blood-Brain and Blood-Tumor Barrier Dynamics in Glioblastoma


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: In 2004, recognizing that work is a critical part of an individual’s recovery, the VHA began to disseminate supported employment to assist Veterans with job placement. While these programs have been very successful in helping Veterans secure competitive employment, maintaining employment continues to be a challenge. Interpersonal difficulties are often associated with job terminations. The goals of this study are to tailor a skills training intervention to Veterans and workplace interactions and to examine the acceptability and feasibility of integrating it with supported employment. Skills training will focus on perspective taking and social problem-solving. Development of an intervention that improves quality of work relationships and job tenure would enhance the quality of care provided within the VHA and would be fully consistent with the President’s New Freedom Commission mandate to develop mental health care services that focus on “increasing consumer’s ability to successfully cope with life challenges, on facilitating recovery, and on building resilience.”

PI_NAMEs: NIENOW, TASHA MARIE (contact)

PROJECT_TERMS: acceptability and feasibility;Attitude;cognitive skill;cohort;Community Integration;Community Participation;coping;Cues;Data;Data Collection;Detection;Development;Education;Educational Curriculum;Educational Intervention;Emotional;Emotions;Employment;Enrollment;evidence base;Evidence based intervention;Evidence based practice;Feedback;follow up assessment;Freedom;Future;Goals;health care service;Healthcare Systems;Hour;improved;Individual;Instruction;interest;Interpersonal Relations;Intervention;Intervention Studies;Interview;Job loss;Learning;Life;Logic;Maintenance;Measures;Mental Health;Mental Health Services;Occupations;Outcome;Participant;participant enrollment;participant retention;Performance at work;Persons;perspective taking;Phase;Pilot Projects;pilot trial;post intervention;Problem Solving;productivity loss;professional atmosphere;programs;promote resilience;psychosocial;Qualitative Methods;Quality of Care;Quality of life;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Reporting;Research;Role;satisfaction;Schedule;Secure;Self Efficacy;Services;severe mental illness;Severities;showing emotion;skills;skills training;social;social cognition;Social Functioning;Social Interaction;social norm;Social Problems;Specialist;Structure;Suggestion;suicidal risk;Supported Employment;Symptoms;Therapeutic;therapy development;Training;Unemployment;uptake;Veterans;Veterans Health Administration;Vocational rehabilitation;Well in self;Work;Workplace

PROJECT_TITLE: Acceptability and Feasibility of Work-Oriented, Veteran-Centric, Social-Cognitive Skills Training

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative This study will characterize messenger RNA (mRNA) methylation in lung tumors and explore the oncogenic role of the RNA methyltransferase METTL3 in lung cancer. This investigation could lead to novel therapeutic strategies to control oncogene expression in lung adenocarcinoma and other tumor types. 1

PI_NAMEs: GREGORY, RICHARD I. (contact);KIM, CARLA F.

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Age;Apoptosis;Binding Sites;Biological Assay;Cancer Biology;Cancer Model;Cells;Cellular biology;Characteristics;Co-Immunoprecipitations;cohort;Complementary DNA;Complex;CRISPR/Cas technology;Data;Diagnosis;effective therapy;Enzymes;epitranscriptome;experience;experimental study;Fibroblasts;Future;gain of function;Gene Expression;Genes;Genetic Transcription;Genotype;Goals;Human;Immunohistochemistry;In Vitro;in vivo;inducible Cre;Inhibition of Cancer Cell Growth;insight;Invaded;Investigation;knock-down;KRASG12D;Lentivirus;Lentivirus Vector;loss of function;Lung;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Messenger RNA;metaplastic cell transformation;Methods;Methyltransferase;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Mutagens;mutant;Normal tissue morphology;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Organoids;overexpression;Pathway interactions;Persons;Phosphorylation;Positioning Attribute;posttranscriptional;Primary Neoplasm;protein expression;Proteins;Proteomics;Regulation;Regulator Genes;Reporter;Research;ribosome profiling;RNA;RNA immunoprecipitation sequencing;RNA methylation;RNA, Messenger, Splicing;Role;Sampling;small hairpin RNA;Survival Rate;Terminator Codon;Testing;therapeutic target;Time;transcriptome;transcriptome sequencing;Transgenic Organisms;Translations;tumor;tumor growth;tumor initiation;tumor progression;tumorigenesis;Woman;Xenograft procedure

PROJECT_TITLE: Role of METTL3 and the m6A Epitranscriptome in cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Viral evolution presents a major challenge to vaccination programs designed to limit the public health and economic impacts of seasonal influenza epidemics. Our research seeks to address this challenge by elucidating the mechanisms that shape influenza A virus evolution.

PI_NAMEs: LOWEN, ANICE C (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acute;Address;Animal Model;Antibodies;Antibody Response;Antibody titer measurement;Bar Codes;Cavia;Color;design;Detection;economic impact;Evaluation;Evolution;fitness;Frustration;Genes;Genetic;genetic linkage;Genetic Structures;Genetic Variation;Heterogeneity;Human;Immunity;Immunization Programs;in vivo;Individual;Infection;Influenza A virus;influenza epidemic;influenzavirus;insight;Knowledge;Location;Modeling;Monitor;Mutation;neutralizing antibody;next generation sequencing;novel;Oranges;Outcome;Pattern;Play;Population;population genetic structure;Population Genetics;pressure;Prevalence;Process;Public Health;Research;response;reverse genetics;Role;sample collection;seasonal influenza;Severities;Shapes;Single Nucleotide Polymorphism;Site;Structure;System;Testing;Tissues;transmission process;Uncertainty;Vaccination;Variant;Viral;Viral Genome;viral transmission;Virus;Virus Diseases;virus genetics

PROJECT_TITLE: Impact of intra-host population structure on influenza virus antigenic evolution