NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Being able to customize healthcare based on each person’s unique genetic makeup could enable an era of genomic medicine that would improve prevention, diagnosis and treatment for many types of health conditions. Achieving this vision requires developing computerized tools that help doctors and patients make sense of individual genomic data to show them how to use that data to make better healthcare decisions. Relevant to NHGRI’s interest in the clinical deployment of genomics, the focus of the proposed research program is in the area of implementation science, and will help to address the challenge of adopting unsolicited genomic results.

PI_NAMEs: TAYLOR, CASEY OVERBY (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;adverse drug reaction;Area;Award;Clinical;clinical care;clinical decision support;Committee Members;computerized tools;dashboard;Data;design;Diagnosis;Disease;empowerment;evidence base;Feedback;Focus Groups;Future;genetic makeup;genomic data;Genomic medicine;Genomics;Goals;Health;health care settings;Health Personnel;Health system;Healthcare;implementation science;improved;Individual;Infrastructure;Institution;Institutional Policy;interest;Learning;meetings;Modeling;Motion;National Human Genome Research Institute;Outcome;Patients;Persons;Pharmacy and Therapeutics Committee;preference;Prevention;Process;programs;provider adoption;Recommendation;Research;Research Methodology;research study;Risk;Role;Science;social;Structure;Surveys;System;Test Result;Testing;Time;Time and Motion Studies;usability;Vision;Work

PROJECT_TITLE: Clinical Decision Support for Unsolicited Genomic Results


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rehabilitation;Substance Misuse

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative The proposed research is highly relevant to public health and specifically to alcohol use disorder, one of the most prevalent mental health disorders, because it will produce a new approach to the analysis of a randomized clinical trial that furthers precision medicine. The new method identifies patient specific predictors of likely response to a test treatment and performs hypothesis tests for treatment differences in the group of likely responders, all in the same study. The method will be applied to data from six completed NIAAA studies and a new method for appraising possibly erroneous model specification and confounding will be utilized.

PI_NAMEs: LASKA, EUGENE M (contact);SIEGEL, CAROLE E

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Address;alcohol abuse therapy;alcohol use disorder;Characteristics;Clinical;clinical trial analysis;Clinical Trials;Combined Modality Therapy;Data;Data Set;Development;Diagnostic;Diagnostic Procedure;Double-Blind Method;Enrollment;Failure;gabapentin;Goals;improved;Individual;Influentials;Knowledge;Machine Learning;machine learning model;Matched Group;member;Mental disorders;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;neural network;novel;novel strategies;Outcome;Outcome Measure;Parameter Estimation;patient subsets;Patients;Performance;personalized medicine;Placebos;precision medicine;predicting response;predictive modeling;primary outcome;Probability;Process;prognostic;prognostic model;Property;Public Health;Publishing;random forest;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reproducibility;Research;Research Project Grants;response;Sampling;secondary analysis;Secondary to;semiparametric;simulation;Site;Specific qualifier value;statistical and machine learning;Subgroup;Testing;treatment choice;treatment comparison;treatment effect;Work

PROJECT_TITLE: Likely responder analysis and tests of model misspecification in randomized controlled trials of treatments for Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Genetic factors that underlie susceptibility to Idiopathic Pulmonary Fibrosis (IPF), a lethal disease of irreversible and progressive lung scarring, are incompletely understood. This application seeks to use state-of- the-art whole genome sequencing to identify genetic variants linked to IPF, to determine how these genetic variants lead to disease, and to extend our knowledge of human telomere-related disease.

PI_NAMEs: GARCIA, CHRISTINE KIM (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adult;Adverse event;Age;Bioinformatics;Biological Assay;Biology;Blood Cells;Candidate Disease Gene;cell type;Cells;Chronic;clinical diagnosis;Code;cohort;Copy Number Polymorphism;CRISPR/Cas technology;Data;Development;Disease;disease diagnosis;disease model;Disease Progression;disease-causing mutation;disorder risk;DNA Sequence Alteration;Engineering;Epithelium;Evaluation;exome sequencing;Exposure to;Fibroblasts;fibrotic interstitial lung disease;fibrotic lung;Functional disorder;gain of function;Gene Frequency;gene function;Gene Mutation;Genes;Genetic;genetic architecture;Genetic Diseases;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic variant;genome editing;genome sequencing;genome wide association study;genome-wide;Genomic approach;genomic locus;Genomic Segment;Genotype;Goals;Grant;Human;human model;idiopathic pulmonary fibrosis;In Vitro;Inherited;Injury;Interstitial Lung Diseases;Investigation;kindred;Knowledge;Lead;Length;Leukocytes;Link;Location;lung development;Lung Diseases;Lung Transplantation;Lymphocyte;Measurement;Methods;mouse model;Mutation;next generation sequencing;novel;Pathogenicity;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Physicians;posttranscriptional;predict clinical outcome;Predisposition;pressure;proband;programs;promoter;Pulmonary Fibrosis;Qualifying;rare variant;response;risk variant;Role;segregation;Slide;Statistical Data Interpretation;Syndrome;Technology;Telomerase;Telomerase RNA Component;telomere;Telomere Shortening;Testing;transcriptomics;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Pulmonary Fibrosis and Telomerase Dysfunction

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Arginine methylation is one of the most common post-translational modifications and plays critical roles in many fundamental cellular processes. This proposal focuses on identifying the upstream signal and regulators of PRMT1/5, as well as demethylases and readers of arginine methylation. We will use a range of complementary methods including biochemistry, mass spectrometric (MS) analysis, molecular and cellular biology, and mouse models in our studies.

PI_NAMEs: GAN, WENJIAN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Amino Acids;Arginine;Binding;Biochemistry;Biology;Cancer Patient;cancer survival;cancer therapy;Cell Physiology;Cells;dimethylarginine;DNA Repair;Enzymes;Genetic Transcription;Goals;inhibitor;Malignant Neoplasms;Mediating;Methods;methyl group;Methylation;Molecular;Molecular and Cellular Biology;mouse model;N,N-dimethylarginine;novel;Pathway interactions;Phosphorylation;Play;Post-Translational Protein Processing;Process;Prognosis;programs;Protein Methylation;Protein-Arginine N-Methyltransferase;Proteins;Reader;Regulation;Research;Role;Signal Pathway;Signal Transduction;Stimulus;Ubiquitination

PROJECT_TITLE: Regulatory Mechanisms of Arginine Methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Our multidisciplinary research team seeks to improve the quality and safety of care hospitalized patients receive by using healthcare engineering, systems approaches, and integrative medicine to enhance patient and provider wellness and strengthen patient-provider relationships. Importantly, we will explore how enhancing the patient-provider relationship can help improve the lived experience of both patient and provider in the hospital, while enhancing patient safety.

PI_NAMEs: SAINT, SANJAY K (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Engineering Whole Health into Hospital Care to Improve Wellness: The M-Wellness Laboratory (M-Well)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: A moderate traumatic brain injury (TBI) occurring in early or middle adulthood might have long-lasting effects on the brain that can accelerate the decline of physical and cognitive function in older age. The proposed study seeks to better understand the implications of aging with a TBI, in order to help Veterans maintain their health and independence. The overarching hypothesis of this new line of research is that participants who experienced a moderate TBI in early or middle adulthood (at least 15 years prior to study enrollment) will have poorer performance on balance and cognitive tests, despite self-reporting no persistent motor or cognitive impairment from the TBI. We also seek to evaluate the potential for practice-based learning and improvement of complex balance tasks in this population, to gain experience for conducting future rehabilitation studies. The long term goal of this line of research is to design rehabilitative and lifestyle interventions to preserve brain health and function in Veterans who have previously experienced a TBI.

PI_NAMEs: CLARK, DAVID J (contact)

PROJECT_TERMS: Acceleration;Acute;Adult;Age;age effect;age group;age related neurodegeneration;Aging;aging process;Area;balance testing;Bone Density;Brain;brain health;Brain Injuries;Chronic;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;comorbidity;Complex;Control Groups;cost;Craniocerebral Trauma;Data Set;design;disability;Eligibility Determination;Enrollment;equilibration disorder;Equilibrium;Exhibits;experience;fall risk;falls;Future;Goals;Gulf War;Health;healthy aging;human old age (65+);Impaired cognition;improved;Individual;Injury;Intervention;Investigation;Knowledge;Learning;life span;Life Style Modification;lifestyle intervention;Literature;Measures;Motor;motor deficit;motor impairment;neuroinflammation;neuroregulation;Neurosecretory Systems;oculomotor;Participant;Pathway interactions;Patient Self-Report;peer;Performance;Persons;Physical Function;Population;Predisposition;preservation;pressure;Process;Recording of previous events;Regression Analysis;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;secondary outcome;Severities;Societies;Testing;Traumatic Brain Injury;Traumatic Brain Injury recovery;Uncertainty;Veterans;visual tracking;Visuospatial

PROJECT_TITLE: Aging with a Traumatic Brain Injury: Implications for Balance Deficits and Fall Risk

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


FUNDING_MECHANISM: OTHERS

ORG_CITY: Decatur

ORG_STATE: GA

PHR: U.S. veterans are more at risk for developing Alzheimer’s disease (AD) than civilians due to risk factors associated with military service, and women are more likely to develop AD than men. AD is a neurodegenerative disease characterized by progressive loss of neuron function and structure. Immune cell dysfunction contributes to massive cell death within the central nervous system. Treatments that have the potential to reverse immune cell activation and mitigate cognitive impairment at early disease stages, prior to neural degeneration and cell death, are urgently needed. Noninvasive audiovisual neurostimulation is a promising new method to alter immune cell activation in mouse models of disease and is already under investigation in human clinical trials. Despite known sex differences in AD, prior studies have not tested the effects of noninvasive neurostimulation in females, which will be addressed in the proposed research.

PI_NAMEs: PRICHARD, ASHLEY  (contact)

PROJECT_TERMS: Address;Affect;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Amyloidosis;Animal Model;arm;Award;Biomedical Engineering;Blood - brain barrier anatomy;brain cell;Brain region;Brain-Derived Neurotrophic Factor;Canis familiaris;career;Career Choice;Cell Death;Cells;Cellular Morphology;Central Nervous System;Chronic;Clinical;Clinical Trials;Cognition;Cognitive deficits;comparative;cytokine;Data;Disease;disease model;Dopamine;Drug Targeting;effective intervention;effective therapy;Etiology;Exposure to;Fellowship;Female;Foundations;Frequencies;Functional disorder;Future;Goals;Grant;High Pressure Liquid Chromatography;Hippocampus;Hour;Human;Immune;immune activation;Immune response;Impaired cognition;improved;Inflammation;Intervention;Investigation;Knowledge;Learning;male;Measures;Memory;Memory impairment;men;Mentors;Methods;Microglia;Microscopy;military service;Modeling;Morphology;mouse model;Mus;Nerve Degeneration;neural stimulation;Neurocognitive;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;Neuromodulator;neuron loss;Neuronal Dysfunction;Neuronal Plasticity;Neurons;neuropathology;neuroregulation;Neurotransmitters;Norepinephrine;novel;Pathology;Performance;personalized medicine;Phenotype;potential biomarker;Prefrontal Cortex;prevent;professor;Proliferating;Protein Analysis;Proteomics;Radial;recruit;Rehabilitation therapy;Research;Research Personnel;Research Technics;Resources;response;Risk;Risk Factors;Rodent Model;Senile Plaques;Sensory Process;sex;Sex Differences;Short-Term Memory;spatial memory;Stress;Structure;tenure track;Testing;therapeutic target;Time;timeline;Training;Training Support;Translating;Trauma;treatment optimization;Universities;Veterans;Visual;Visual Cortex;water maze;Wild Type Mouse;Woman;Writing

PROJECT_TITLE: Noninvasive Neurostimulation to Reduce Pathology in a Female Mouse Model of Alzheimer's Disease

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative We propose renewal of the University of Alabama at Birmingham (UAB) health services research (HSR) T32 training program, with 4 predoctoral and 5 postdoctoral slots per year. MPD/MPI Michael Mugavero, MD, MHSc and Emily Levitan, ScD collaborate with 9 Core Faculty and 49 Participating Faculty Mentors to deliver health services research and professional skills training to diverse cohorts of trainees. Our overarching goal is to train change agents who use these skills to improve health outcomes and overcome health disparities in Alabama, across the Deep South, and in other regions in the U.S.

PI_NAMEs: LEVITAN, EMILY B;MUGAVERO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: UAB Health Services Research (HSR) Training Program


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Harvard-wide pediatric Health Services Research (HPHSR) Fellowship is a 30 year collaboration of Boston Children’s Hospital, Massachusetts General Hospital for Children, and the Harvard Department of Population Medicine/Harvard Pilgrim Healthcare Institute. Our multidisciplinary, well-funded faculty provide exemplary training in pediatric health services research and implementation science within leading health systems. This program has an amazing training record- the 154 alumni include 18 graduates from racial or ethnic groups underrepresented in medicine, 61 in academic or research leadership positions including 16 CMOs or Senior VPs, and four alumni elected to the National Academy of Medicine

PI_NAMEs: GARABEDIAN, LAURA FADEN;WALSH, KATHLEEN ELIZABETH (contact)

PROJECT_TITLE: Training in Child Health Services Research and Implementation Science


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Hearing impairment affects over 30 million Americans and can significantly impact their day-to-day life. There are currently no regenerative approaches available in the clinics to reverse hearing loss in the human inner ear. By comparing the regeneration potential in the inner ear between a highly regenerative versus a non- regenerative animal model, this proposed research will identify potential elements from the regenerative species to inform new therapeutic strategies to restore hearing in humans.

PI_NAMEs: SHI, TUO  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age Months;American;Animal Model;ATAC-seq;Automobile Driving;Bacterial Artificial Chromosomes;Birth;Cell Nucleus;Chromatin;Clinic;Cochlea;Code;combinatorial;Conserved Sequence;CRISPR/Cas technology;Data;design;DNA Sequence;Elements;Enhancers;Enzymes;Epigenetic Process;experimental study;Fishes;Future;Generations;Genes;hair cell regeneration;Hair Cells;hearing impairment;hearing restoration;Histones;Homeostasis;Human;Injury;Inner Hair Cells;Labyrinth;Learning;Life;Maintenance;Mammals;Modeling;Mus;Natural regeneration;novel;novel therapeutic intervention;Organ;Patients;postnatal;prevent;Production;Proliferating;Property;public health relevance;regeneration following injury;regeneration potential;regenerative;regenerative approach;Regenerative capacity;Regulation;Regulatory Element;Repression;Research;response to injury;Rest;restraint;Role;Sensory Hair;Supporting Cell;Testing;transcription factor;transdifferentiation;Up-Regulation;Vertebrates;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: Species-Specific Epigenetic Basis of Zebrafish Inner Ear Hair Cell Regeneration


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stroke;Transplantation

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Ischemic stroke is an important clinical problem with limited treatment options beyond the first several hours, whereafter infarcted lesion cores are remodeled with fibrotic scar that does not support neural repair. Promoting neural repair at lesion cores will require altering natural stroke wound healing processes to dynamically reestablish viable neurovascular and glia barrier functions. In this proposal, we will use multi-modal intravital imaging methods to longitudinally track cell graft induced glia repair outcomes in sub-acute stroke lesions.

PI_NAMEs: O'SHEA, TIMOTHY MARK (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Acute;Address;Adult;angiogenesis;Astrocytes;Axon;Behavioral;Blood flow;Blood Vessels;Cell Count;Cell Transplantation;Cells;Central Nervous System;central nervous system injury;Certification;Cicatrix;Clinical;Cognitive deficits;cohort;Competence;Contrast Media;Cues;density;Effectiveness;Environment;Extravasation;Fibrosis;Fostering;Future;Goals;Growth;healthcare burden;Hour;imaging modality;Immune;Immunohistochemistry;improved;in vivo;Infarction;Infiltration;Injury;insight;Intravenous;intravital imaging;Ischemia;Ischemic Stroke;Knowledge;Lesion;Mammals;Maps;Methods;Modeling;Molecular;Morphology;Multimodal Imaging;multimodality;Mus;Natural regeneration;Nature;neonate;Nerve Regeneration;nerve stem cell;neural circuit;neural repair;Neuroglia;Neurons;Neurophysiology - biologic function;neurovascular;novel;Optical Coherence Tomography;Organism;Outcome;Perfusion;Peripheral;Permeability;permissiveness;Phase;Phenotype;Population;Positioning Attribute;post stroke;Process;Proliferating;Recovery;Recovery of Function;repair function;repaired;Reporter;restoration;Saline;Serum Proteins;Source;Stroke;stroke therapy;System;Time;Tissues;Translations;Transplantation;two photon microscopy;Work;wound healing;wound response;Zebrafish

PROJECT_TITLE: Intravital Imaging of Transplant Evoked Glia Repair in Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative A large number of research and clinical studies derive information on the functional connectivity, within and between neural circuits in the brain, by analyzing statistical correlations between small signal fluctuations from different brain areas that are measureable during acquisitions of MRI images while a subject is at rest. However, the interpretation of these correlations as indices of functional connectivity has not been substantiated. The studies proposed would establish the relationships between these MRI metrics of connectivity and results obtained by other means of exciting or modifying neural circuits, including gold standard electrophysiological recordings of neural electrical activity, maps of anatomic connections from injected tracers, and behavioral effects, in non-human primates.

PI_NAMEs: CHEN, LI MIN ;GORE, JOHN C (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: anatomical tracer;Anatomy;Animal Behavior;Animal Model;Animals;Architecture;Area;Automobile Driving;Behavior;behavior prediction;Behavioral;Bilateral;Biophysics;Brain;Brain region;Cells;Cerebral cortex;Clinical Research;Correlation Studies;Data;Data Correlations;Deafferentation procedure;Dependovirus;Electrodes;Electrophysiology (science);excitatory neuron;Exhibits;experimental study;Functional Magnetic Resonance Imaging;Goals;Grant;Hand functions;hippocampal pyramidal neuron;Histology;Human;Image;indexing;Interneurons;Intervention;Location;Magnetic Resonance Imaging;Maintenance;Maps;Measurement;Measures;Methods;Microelectrodes;microstimulation;millimeter;Monkeys;multimodality;neural;neural circuit;Neurobiology;Neurons;neuroregulation;nonhuman primate;Opsin;Optics;optogenetics;Output;Pattern;Performance;Population;post intervention;Primates;Recovery;Research;research study;Resolution;response;Rest;Saimiri;sensorimotor system;sensory system;Signal Transduction;simulation;Site;skills;Somatosensory Cortex;Spinal;Spinal Cord;Stimulus;Structure;System;Techniques;Thalamic structure;Tracer;Transfection;Uncertainty;Variant;vibrotactile stimulation;Virus

PROJECT_TITLE: Biophysical Basis of Functional Connectivity by MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Hearing Loss;Neurofibromatosis;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The hallmark of neurofibromatosis type 2 (NF2) is bilateral vestibular schwannomas (VSs), tumors that cause progressive hearing loss and are associated with substantially negative impacts to quality of life. Identifying well-tolerated drugs to halt VS growth and ameliorate VS-associated hearing loss is a major unmet medical need. This project will provide pivotal insight into i) the role and mechanisms of HMGB1 in driving neuroinflammation in VS, ii) the treatment potential and the hearing response following HMGB1 blockade, and iii) the design of a future clinical trial for VS using a novel combination strategy of HMGB1 and EGFR blockade to concurrently control tumor growth and prevent VS-induced hearing loss.

PI_NAMEs: STANKOVIC, KONSTANTINA M;XU, LEI  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acoustic Neuroma;Amplifiers;Auditory;Automobile Driving;bilateral vestibular Schwannoma;Bone Marrow;Brain;Cessation of life;chemokine;Clinical Trials;Cochlea;Compensation;cytokine;Data;deafness;design;Disease;Drug Kinetics;effective therapy;efficacy evaluation;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;experimental study;Facial paralysis;Future;Genetic;Goals;Growth;Growth Inhibitors;Hearing;hearing impairment;hearing preservation;HMGB1 gene;Impairment;improved;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Ligands;loss of function;Macrophage;Medical;Modeling;Morbidity - disease rate;mouse model;Mus;neoplastic cell;Neurofibromatosis 2;neuroinflammation;new therapeutic target;novel;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;prevent;prevent hearing loss;Production;progressive hearing loss;Property;Quality of life;Radiation therapy;receptor;recruit;response;Risk;Role;Sensorineural Hearing Loss;Signal Transduction;standard care;Stroke;Testing;Treatment Efficacy;tumor;tumor growth;Tumor-associated macrophages

PROJECT_TITLE: Targeting HMGB1 to improve hearing andenhance therapy for Vestibular Schwannomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-W(03)M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Depression;Disability Research;Mental Health;Rehabilitation;Social Determinants of Health;Stroke

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative  Clinicians use patient-reported measures to understand how communication impairments impact daily life for people with post-stroke speech and language disorders. However, the data from these measures may be misinterpreted and misused in treatment planning if clinicians have not also considered how the client’s psychosocial perspectives (depression, chronic stress, resilience, or self-efficacy) interact with the communication impairment in daily life. In this project, we will examine how clients’ psychosocial perspectives contribute to communicative participation as reported on a common patient-reported measure so that we may guide how clinicians integrate this information into their clinical activities.

PI_NAMEs: BAYLOR, CAROLYN RAE;POMPON, REBECCA HUNTING (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adjuvant;Adult;Age;Aphasia;Area;biopsychosocial;Chronic stress;Client;Clinical;clinical development;clinical practice;clinically significant;Collaborations;Communication;Communication impairment;Complex;coping;Data;Depressive disorder;experience;Family;follow-up;Goals;Health;high risk;Impairment;improved;Individual;individual patient;individualized medicine;interest;Intervention;Interview;Knowledge;Language;Language Disorders;language impairment;Language Tests;Learning;Life;Measurement;Measures;Mental Depression;Methods;Minor;Motor;Nature;neglect;Occupational;Outcome;Outcome Measure;Participant;Pathologist;Patient Outcomes Assessments;Patient Participation;patient response;Patient-Centered Care;Patients;Persons;Physical environment;physical impairment;Play;post stroke;psychosocial;Psychosocial Factor;Psychosocial Influences;psychosocial resources;Questionnaires;Reporting;Research;Research Methodology;Research Project Grants;resilience;Resources;response;Risk;Role;Self Efficacy;Services;Severities;Shapes;social;Social Environment;Speech;Speech Disorders;Stroke;stroke survivor;Survey Methodology;Surveys;Time;Training;treatment optimization;Treatment outcome;treatment planning;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical interpretation and application of patient-reported communicative participation outcomes after stroke, and the influence of psychosocial factors

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Informing health policy requires a broad array of skills and knowledge. The Harvard Health Policy Training Program seeks to train investigators in health policy and health services research with the goal of improving the affordability, efficiency, equity, financing, and quality of health care. The program has successfully trained social scientists who have expanded the evidence base for the field.

PI_NAMEs: CUTLER, DAVID M (contact)

PROGRAM_OFFICER_NAME: DESOTO, MAUSHAMI

PROJECT_TITLE: Health Policy Training Grant


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Pathological axon degeneration is a hallmark of many neurodegenerative conditions. We recently discovered that Schwann cells, the glia of the peripheral nervous system, protect injured axons through a metabolic coupling mechanism which likely supports axonal bioenergetics. The main goal of this proposal is to examine how manipulation of metabolic coupling regulates axonal bioenergetics, thus impacting the survival of axons after acute and subacute injuries.

PI_NAMEs: BABETTO, ELISABETTA  (contact);BEIROWSKI, BOGDAN

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Affect;afferent nerve;Antineoplastic Agents;Axon;axon injury;axonal degeneration;axonopathy;Bioenergetics;Biosensor;Cessation of life;Chemotherapy-induced peripheral neuropathy;Citric Acid Cycle;cofactor;combat;Complex;Coupling;Critical Pathways;Cytoplasm;Data;Deceleration;Defect;deprivation;Development;Disease;disease model;Electron Transport;Energy Metabolism;Energy Supply;Enzymes;Etiology;Event;exhaust;extracellular;Failure;Functional disorder;Future;Glycolysis;Goals;Iatrogenic Disease;Image;improved;in vivo;Injury;Measures;Mediating;Metabolic;methyl pyruvate;Mitochondria;Modeling;Molecular;Motor;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurologic Deficit;Neurological disability;neuronal cell body;Neurons;novel;novel therapeutic intervention;Oligodendroglia;Paclitaxel;Pathologic;Pathway interactions;Patients;Peripheral Nervous System;personalized approach;Physiological;Positioning Attribute;Process;Production;programs;Publishing;Pyruvate;pyruvate carrier;Pyruvate Dehydrogenase Complex;Respiration;respiratory;response to injury;Role;Schwann Cells;Signal Transduction;Stereotyping;Stimulus;Therapeutic;therapeutic target;Thinking;Time;tool;Up-Regulation;uptake;Vertebrates;Wallerian Degeneration;Work

PROJECT_TITLE: Energizing and Protecting Axons Through Metabolic Coupling to Schwann Cells

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) and its ablation remains challenging, preventing cure of the disease. This project will use artificial intelligence methods to identify regional CT imaging features with the goal of identifying personalized targets for ablation. The project will also seek to provide insights into anatomic differences between AF patients who are likely to suffer recurrence from those who are not, using genetic and electrical mapping.

PI_NAMEs: BARNARD, JOHN ;CHUNG, MINA KAY (contact);MADABHUSHI, ANANT

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 4q25;Ablation;Affect;Anatomy;Artificial Intelligence;artificial intelligence method;Atlases;Atrial Fibrillation;auricular appendage;Biological;Cardiac;Cardiac ablation;Chromosomes;Clinic;Clinical;Clinical Data;cohort;Computers;Computing Methodologies;Data;Disease;explainable artificial intelligence;Fractals;Genes;Genetic;Genetic Risk;genetic variant;genomic locus;Genomics;Goals;Image;Image Analysis;imaging biomarker;Imaging Device;imaging platform;improved;Individual;insight;Left;Left atrial structure;Length;machine learning method;Maps;Measurement;Medical;Methods;Modeling;Molecular;Morphology;Myocardial;National Heart, Lung, and Blood Institute;Nomograms;non-invasive imaging;novel;Patient Selection;Patients;Performance;predictive marker;Predisposition;prevent;Procedures;prognostic value;Pulmonary veins;radiological imaging;radiomics;Recommendation;reconstruction;Recurrence;Reporting;Research;Risk;risk prediction;risk variant;Scanning;Site;Slice;Structure;success;supervised learning;Testing;Thick;tool;unsupervised learning;Variant;voltage;X-Ray Computed Tomography

PROJECT_TITLE: RADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATION

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project narrative Each cell in the human body contains two meters of DNA that need to be packaged in the tiny micrometer- sized cellular nucleus. This proposal describes new methodologies that can be used to study this process both in vitro and in cells. Understanding the mechanisms of DNA packaging will shed light on normal cell differentiation and development and on the molecular origins of disease such as cancer.

PI_NAMEs: DEBELOUCHINA, GALIA  (contact)

PROJECT_TERMS: Acetylation;Age;Biological;biological systems;Biology;biophysical properties;Cell Differentiation process;Cell Nucleus;Cells;Chemicals;Chromatin;Chromatin Structure;Complex;Data;design;Development;Disease;DNA;DNA Packaging;DNA Sequence;Environment;Gene Silencing;genetic information;Heterochromatin;Human body;In Vitro;insight;Investigation;Laboratories;Liquid substance;Malignant Neoplasms;meter;Methodology;Methylation;Modification;Molecular;NMR Spectroscopy;Normal Cell;Nuclear Magnetic Resonance;Output;Phase;Polymers;Post-Translational Protein Processing;Process;protein complex;Protein Dynamics;protein structure;Proteins;Resolution;Signal Transduction;solid state nuclear magnetic resonance;Stress;structural biology;Technology;Therapeutic Agents;tool;Translating

PROJECT_TITLE: Structural biology of chromatin in vitro and in cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: PATHOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PUBLIC HEALTH RELEVANCE The airway epithelium is the crucial host defense against lung injury and infections. It plays a key role in the development of lung diseases and is an emerging target for new therapies. However, our understanding of how this important barrier is fundamentally regulated is limited. Thus, it is paramount to identify new key regulators of this tissue. Multiciliated cells (MCCs), critical within this epithelium, nucleate up to 300 motile cilia at their apical surface to generate directional fluid flow which constantly cleans airways from inhaled pathogens, pollutants and dust to maintain pulmonary health (mucociliary clearance). Notably, airway ciliated cells are the primary targets of human SARS-CoV-2 infection. Moreover, impaired clearance by defective MCCs, either acquired or due to genetic ciliopathies, causes chronic airway infections and COPD and is associated with asthma. Our new studies produced compelling evidence that the E2f7 and E2f8 members of the E2f family of transcription factors have previously unknown essential roles in the early phases of multiciliogenesis. Moreover, human E2f7 and E2f8 are dysregulated in patients with asthma, fibrosing interstitial lung diseases and COPD. Furthermore, E2f7 and E2f8 directly regulate human primary ciliary dyskinesia-associated genes. The proposed research is relevant to public health because it will comprehensively define the essential role of E2f7 and E2f8 as master regulators of MCC differentiation, with the long-term goal to use this knowledge to design innovative therapies and diagnostic strategies for chronic airway diseases. This research is relevant to the mission of NHLBI pertaining to stimulating basic discoveries about airway diseases.

PI_NAMEs: MOLL, UTE MARTHA (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Ablation;Adult;Airway Disease;airway epithelium;Allergens;Apical;Asthma;Basal Cell;Biogenesis;Biosensor;Biotin;CDK2 gene;Cell Cycle;Cell Cycle Kinetics;Cell Cycle Progression;Cell Differentiation process;Cell division;Cells;Centrioles;Centrosome;ChIP-seq;Chromatin Remodeling Factor;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Cilia;ciliopathy;cilium biogenesis;cilium motility;Classification;Complex;Cytoplasm;design;Development;diagnostic strategy;DNA biosynthesis;Dust;E2F transcription factors;Ependyma;Epithelium;Family;Fertility;fibrotic interstitial lung disease;fluid flow;Gene Expression;gene network;Genes;Genetic;genetic corepressor;Genetic Transcription;genome-wide;Goals;Homeostasis;Host Defense;Human;human disease;Impairment;in vivo;Inhalation;Inherited;Innovative Therapy;insight;kinetosome;Knowledge;lung development;Lung Diseases;lung health;Lung infections;lung injury;Mammalian Oviducts;Mammals;Maps;Mass Spectrum Analysis;member;Mission;Mitotic;Molecular;Motility;Mucociliary Clearance;multiple omics;Mus;mutant;National Heart, Lung, and Blood Institute;Natural regeneration;neurogenesis;new therapeutic target;notch protein;novel;novel therapeutic intervention;pathogen;Pathway interactions;Patients;Phase;Phenotype;Physiological;Plants;Play;pollutant;Population;Prevention;Primary Ciliary Dyskinesias;Process;progenitor;programs;Proliferating;Proteins;Public Health;public health relevance;Research;Resolution;Respiration;respiratory;Respiratory Tract Infections;Role;SARS-CoV-2 infection;sensor;single cell ATAC-seq;single-cell RNA sequencing;spatiotemporal;stem cells;Surface;Testing;Time;Tissues;Trachea;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Regulation;Trimethoprim-Sulfamethoxazole;tumorigenesis;Validation;Visualization;Work

PROJECT_TITLE: A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biomedical Imaging;Chronic Pain;Clinical Research;Fibromyalgia;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research;Peripheral Neuropathy;Rheumatoid Arthritis;Urologic Diseases;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Improving pain management is a critical need of the U.S. healthcare system. This project leverages quantitative sensory testing and brain imaging methods to identify key mechanistic similarities and differences across somatic and visceral pain conditions, including rheumatoid arthritis, osteoarthritis, and bladder pain syndrome. The fundamental knowledge drawn from these investigations supports the NIH mission to enhance public health by its potential to provide novel insights for pain treatment.

PI_NAMEs: WALLER, NOAH C. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acoustic Stimulation;Address;allodynia;analog;arthritic pain;Attention;Auditory;Biological;Bone Tissue;Brain;Brain imaging;career;Carpal Tunnel Syndrome;Central Nervous System;central pain;central sensitization;Characteristics;chronic pain;chronic pain patient;chronic painful condition;chronic pelvic pain;cohort;Data;Data Set;Degenerative polyarthritis;Development;Diagnosis;Diagnostic;Disparity;Economic Burden;Elements;Exhibits;Fatigue;Fibromyalgia;fibromyalgia patients;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Goals;Gynecologic;Healthcare Systems;Heterogeneity;Hip Osteoarthritis;Hyperalgesia;Hypersensitivity;Hysterectomy;imaging modality;improved;Individual;insight;Insula of Reil;interdisciplinary approach;Interstitial Cystitis;Investigation;Knowledge;Label;Literature;Lower urinary tract;Measures;Mediating;Mentors;Methods;Mission;multimodality;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;neural;Neurobiology;neuroimaging;Nociception;novel;Organ;osteoarthritis pain;Outcome;Outcome Measure;Overactive Bladder;Pain;Pain Disorder;Pain Free;Pain management;pain perception;pain processing;Pain Research;Painless;Participant;Patient Outcomes Assessments;Patients;Pelvic Pain;Peripheral;Phase;Phenotype;Photic Stimulation;poor sleep;Protocols documentation;Public Health;Reporting;Research;Research Activity;Research Personnel;response;Rest;Rheumatoid Arthritis;Sensory;social;soft tissue;somatosensory;Symptoms;Syndrome;Techniques;Testing;Time;tool;training opportunity;United States National Institutes of Health;urologic;urologic chronic pelvic pain syndrome;Viscera;Visceral;Visceral pain;Visual;Work

PROJECT_TITLE: Nociplastic mechanisms in somatic and visceral pain


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative. This project will dissect the role of an metabolite called Lac-Phe that suppresses body weight and obesity. This project will contribute fundamental knowledge about lactate biochemistry and the role of lactate-derived metabolites in tissue crosstalk and energy balance.

PI_NAMEs: LONG, JONATHAN Z (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Ablation;Anabolism;Biochemical;Biochemical Pathway;Biochemistry;Body Weight;candidate identification;Cell surface;Cell Surface Proteins;cell type;Cells;Circulation;Complement;Data;Data Set;Eating;energy balance;Energy Metabolism;Enzymes;Excretory function;Exercise;Exhibits;feeding;Foundations;functional group;Future;Homeostasis;human subject;in vitro activity;in vivo;insight;interest;Kidney;Knockout Mice;Knowledge;Ligands;Liquid substance;LoxP-flanked allele;Macrophage;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Molecular;Molecular Target;Mus;Mutagenesis;Nature;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity treatment;Organ;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Population;Post-Translational Protein Processing;Production;Publishing;Reagent;receptor;reconstitution;Regulation;Reporting;Role;screening;Signal Transduction;Signaling Molecule;solute;Source;Testing;Therapeutic;Tissues;Transfection;Work

PROJECT_TITLE: Role of a lactate-derived signaling metabolite in tissue crosstalk and energy balance

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance The U.S. health system continues to experience multiple pressures and dramatic transformations in the organization and delivery of care. There is great need for well-trained researchers to help assure the quality and safety of care that is delivered, to determine how it should be organized and paid for, and to assure equitable access and outcomes. The proposed training program at Johns Hopkins will prepare multidisciplinary PhD researchers to meet these needs.

PI_NAMEs: DY, SYDNEY MORSS (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Training in Health Services Research


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

PHR: PROJECT NARRATIVE As the rates of multi-drug resistant Neisseria gonorrhoeae (NG) continue to increase globally, determining the role of pharyngeal NG (pNG) infections, which are largely asymptomatic and are implicated in the emergence of antimicrobial resistance (AMR) in NG, has become a critical area of research to prevent further emergence of AMR. We propose an epidemiological study to define predictors of pNG infection, characterize AMR in pNG, and to adapt a single-cell molecular assay to improve characterization of AMR in pNG. Through the use of a multi- pronged approach combining clinical, microbiological, genomic, demographical and behavioral data, and novel diagnostics, this project addresses critical gaps in our understanding of pNG infections, AMR, and increases capacity building for development of diagnostics for AMR.

PI_NAMEs: MELENDEZ, JOHAN HUMBERTO (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Anti-microbial susceptibility;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;Azithromycin;Basic Science;behavior prediction;Behavioral;Bioinformatics;Biological;Biological Assay;career;career development;Ceftriaxone;Cells;Ciprofloxacin;Clinical;Clinical Data;clinical predictors;clinically relevant;Collaborations;cross reactivity;Data;Detection;detection assay;Developing Countries;Development;Diagnostic;diagnostic development;Drug-resistant Neisseria Gonorrhoeae;emerging antimicrobial resistance;epidemiologic data;Epidemiology;epidemiology study;Exhibits;experience;experimental study;Frequencies;Future;Gene Transfer;Genetic;Genitourinary system;genome analysis;genome sequencing;genomic data;genomic epidemiology;Genomics;Goals;Gonorrhea;Heterosexuals;high risk;HIV;Horizontal Gene Transfer;improved;In Vitro;Infection;Knowledge;low income country;male;Mediating;men;men who have sex with men;Mentored Research Scientist Development Award;Mentors;Methods;Microfluidics;Molecular;Molecular Epidemiology;Monitor;Morbidity - disease rate;mosaic variant;Multi-Drug Resistance;Neisseria;Neisseria cinerea;Neisseria gonorrhoeae;novel;novel diagnostics;Oral;Oropharyngeal;Participant;patient oriented research;Penicillins;Performance;Pharyngeal structure;pilot test;Play;prevent;Prevention strategy;programs;Public Health;Public Health Practice;Recommendation;Records;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resistance;Resistance development;Resistance profile;Resistance to infection;Resource-limited setting;Risk;Role;Sampling;Scientist;Sexually Transmitted Diseases;skills;Source;Specificity;Statistical Data Interpretation;Surveillance Program;Testing;Tetracyclines;Training;Translational Research;transmission process;Treatment Failure;trend;Uganda;United States;Urethra;Urethritis;Visit;whole genome;World Health Organization

PROJECT_TITLE: Characterizing Antimicrobial Resistance in Pharyngeal Neisseria gonorrhoeae Infections and the Role of Commensal Neisseria Species

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Myocardial edema is a common feature of many cardiac injuries including myocardial infarction (MI), a major public health epidemic but the extent to which edema is causally related to myocardial dysfunction remains unclear. By targeting endothelial vascular permeability, we developed a mechanism-based approach to suppress edema while avoiding confounding pleotropic effects. The goals of this project are to: 1) Uncover the effects of myocardial interstitial edema on post-MI myocardial function and remodeling; 2) Study the link between development of myocardial edema following MI and the pathogenesis of ventricular arrhythmias, and 3) Develop, validate and translate first in class human anti-edema mAb for MI.

PI_NAMEs: SIMONS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute;Acute myocardial infarction;acute stroke;Adherence;Affect;Affinity;Angiogenesis Inhibitors;Animal Model;Arrhythmia;BAY 54-9085;bevacizumab;Binding;Biological;Blocking Antibodies;blocking factor;Blood flow;Brain;cadherin 5;Cardiac Output;Cardiovascular Pathology;Chronic;Chronic Phase;Coronary;Data;Defect;Development;Edema;Electrophysiology (science);Endothelial Cells;Endothelium;Epidemic;Event;Extracellular Matrix;fibroglycan;Fibrosis;Genetically Engineered Mouse;Goals;Hand;Heart;Heart failure;heart function;Heart Injuries;Hemorrhage;Human;human monoclonal antibodies;Hypokalemia;Immunoglobulin G;improved;in vivo;Incidence;Infarction;Inflammation;Inflammatory;Injury;interstitial;Ischemia;KDR gene;Kinetics;Knock-out;Lead;Left Ventricular Dysfunction;Link;Liquid substance;Lymphatic function;Maintenance;Malignant Neoplasms;Membrane;microCT;Molecular;Monoclonal Antibodies;Mus;mutant;Myocardial;Myocardial dysfunction;myocardial infarct sizing;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;novel;novel strategies;Organ;Outcome;Pathogenesis;Permeability;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;pre-clinical;preservation;prevent;Production;Protein Dephosphorylation;Public Health;receptor;Recovery of Function;Reperfusion Injury;Reperfusion Therapy;response;Role;Safety;Severities;Signal Transduction;Site;Structure;sudden cardiac death;systemic inflammatory response;Therapeutic;Time;Translating;Translations;Validation;Vascular Endothelial Growth Factors;vascular endothelium permeability;Vascular Permeabilities;Ventricular Arrhythmia;Ventricular Tachycardia;wound healing;wound injury

PROJECT_TITLE: Ischemia/Reperfusion injury and Myocardial edema

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Neuroimaging is a highly multidisciplinary field in which technology is rapidly developing, leading to a high demand for trained researchers in academia and industry. This program will provide postdoctoral fellows at the University of Minnesota research opportunities and training to prepare them for independent neuroimaging research careers that will help meet this demand.

PI_NAMEs: NETOFF, THEODEN I (contact);UGURBIL, KAMIL

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Minnesota Neuroimaging Postdoctoral Training Grant


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pediatric - AIDS;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The primary purpose of this proposal is to support ongoing mentorship of early career investigators from the US and Africa in conducting global patient-oriented research, with the ultimate goal of strengthening sustained capacity for performing clinical research in Africa. The specific research aims of this project include studies of the role of HIV co-infection in several aspects of SARS-CoV-2 infection in Botswana (specifically, the impact of HIV on long COVID and on the emergence of SARS-CoV-2 mutations/variants in populations and within individuals, both in the presence and absence of prior SARS-CoV-2 vaccination). Other research aims pertain to the impact of different HIV treatment regimens during pregnancy on cardiometabolic risk factors in women and their role in pregnancy outcomes and child health and growth (including pregnancy and postpartum weight gain, and markers of diabetes and metabolic syndrome in pregnancy).

PI_NAMEs: LOCKMAN, SHAHIN  (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: 2019-nCoV;Address;Adult;adverse pregnancy outcome;Africa;African;African ancestry;African Women;Age;antenatal;Antimicrobial Resistance;antiretroviral therapy;Area;Behavior;behavioral outcome;Birth;Body mass index;Body Weight Changes;Botswana;cardiometabolic risk;cardiometabolism;career;Child;Child Health;Clinical;Clinical Research;co-infection;cohort;Communicable Diseases;Communities;Country;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Data;Databases;design;Development;Diabetes Mellitus;Electronics;emerging pathogen;Enrollment;Environment;Epidemic;Evolution;excessive weight gain;experience;Exposure to;Faculty;follow-up;Fumarates;Funding;Future;Genomics;Glycosylated hemoglobin A;Goals;Grant;Growth;Guidelines;Health;HIV;HIV anti-retroviral;HIV Infections;HIV risk;HIV-1;HIV/AIDS;Human immunodeficiency virus test;Income;Individual;infection rate;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratory Research;Lead;Long COVID;Malaria;Maternal and Child Health;maternal weight;Mentors;Mentorship;metabolic rate;Metabolic syndrome;Mutation;neurodevelopment;neuropsychiatric symptom;new pandemic;next generation;Outcome;patient oriented;patient oriented research;Pattern;perinatal HIV;Persons;Population;Positioning Attribute;postpartum weight;Postpartum Women;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal exposure;Prevalence;Prevention trial;previous epidemic;Productivity;Protocols documentation;Randomized;randomized trial;Recommendation;Recurrence;Regimen;Research;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk Factors;Role;Sampling;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;Secure;severe COVID-19;skills;Southern Africa;Students;Tenofovir;Testing;Time;Toxic effect;Training;treatment arm;treatment program;Treatment Protocols;Tuberculosis;Vaccinated;Variant;Viral;Weight Gain;Woman

PROJECT_TITLE: Mentoring in Global Patient-Oriented HIV Research in the Era of COVID-19 and Universal ART

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focuses on developing new, objective, physiologic- based monitoring methods for adolescent suicidality, an exponentially rising disease in the United States, and overwhelming emergency departments. These methods lead to the potential for significant advances in early detection and utilization of therapeutic interventions when dynamic suicidality changes occur in the outpatient setting. This competitive application aligns with three of the NIMH's strategic goals, including increased preventative measures for early detection, research to study mental illness trajectory over time, and increased public health impact through the ED, where preventive efforts may be introduced/implemented.

PI_NAMEs: SHERIDAN, DAVID CLARK (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;Admission activity;Adolescence;Adolescent;adolescent patient;adolescent suicide;Affect;Age;Ambulatory Monitoring;Arousal;Autonomic nervous system;Biometry;career development;Cause of Death;Childhood;Clinical;clinical predictors;Clinical Research;Clinical Trials;cost;Data;Data Analyses;Data Set;design;developmental psychology;Devices;digital monitoring;Disease;Early Diagnosis;Early identification;Early Intervention;Ecological momentary assessment;Emergency department visit;Enrollment;Family;Frequencies;Funding;Future;Gender;Goals;Health Personnel;Healthcare Systems;heart rate monitor;heart rate variability;Hospitals;Impairment;improved;innovation;Intervention;Knowledge;Lead;Life;longitudinal dataset;Machine Learning;machine learning model;Measures;Mental disorders;Mental Health;Mentored Clinical Scientist Development Program;Methodology;Methods;Mining;Mission;Monitor;Moods;National Institute of Mental Health;novel;Observational Study;Outpatients;Patient Self-Report;Patients;pediatric patients;Photoplethysmography;Physicians;Physiological;Positioning Attribute;predictive tools;Preventive;Preventive measure;programs;prospective;Prospective cohort;Psyche structure;psychiatric inpatient;Public Health;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Scientist;Services;Severities;Signal Transduction;social;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;Symptoms;System;Techniques;Therapeutic;Therapeutic Intervention;Time;Time trend;Training;Translational Research;Triage;United States;Visit;wearable data;wearable device;Wrist;wrist motion;Youth

PROJECT_TITLE: Detecting Adolescent Suicidality Biometric Signals and Dynamic Variability with Wearable Technology

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Prematurity is a significant public health problem that increases risk of developmental disabilities, but little is known about factors that contribute to resiliency (positive outcome despite risk). This research aims to increase fundamental knowledge about the flexibility and resiliency of the developing preterm brain through state-of-the- art brain imaging and identification of specific socioenvironmental factors that impact resiliency. This knowledge will lead to improved prediction of outcomes and development of interventions to improve those outcomes.

PI_NAMEs: BARNES-DAVIS, MARIA E (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 11 year old;6 year old;Accounting;Age;Area;Behavioral;Biological Markers;Birth;Birth Records;Brain;brain based;Brain imaging;Brain Injuries;Bypass;Child;Clinical;Cognition;cohort;Cohort Studies;Data;Development;Developmental Disabilities;Diffusion Magnetic Resonance Imaging;Educational workshop;Environment;Environmental Risk Factor;Epidemiologic Methods;Epidemiology;Evaluation;Exhibits;experimental study;extreme prematurity;flexibility;Fostering;Functional Magnetic Resonance Imaging;Funding;Generations;Goals;imaging biomarker;improved;Knowledge;Language;Language Development;Magnetoencephalography;Mentored Clinical Scientist Development Program;Mentors;Multimodal Imaging;multimodal neuroimaging;neural network;Neurocognitive Deficit;Neurodevelopmental Impairment;neuroimaging;Neuronal Plasticity;neuroprotection;Outcome;outcome prediction;Pathway interactions;Phenotype;predictive marker;Pregnancy;premature;prognostic tool;promote resilience;Public Health;Quality of life;recruit;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;School-Age Population;Science;social adversity;Social Environment;socioenvironmental factor;Statistical Methods;statistics;theories;therapy development;tool;Training;white matter injury;Work

PROJECT_TITLE: Towards biomarkers of resiliency in the extremely preterm child: a multimodal neuroimaging study of brain and environment

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Neurosciences;Physical Activity

ORG_DEPT: NEUROSCIENCES

PHR: The benefits of sustained, regular exercise are well-recognized by the public and often advocated by medical professionals. However, the benefits of acute exercise on the brain have not been well-studied. Using single episodes of voluntary exercise in mice, we identified a novel activity-dependent molecule that we hypothesize is an effector of synaptic plasticity and a trigger for enhanced learning and memory in the hippocampus.

PI_NAMEs: WESTBROOK, GARY L (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Address;Advocate;Affect;Attention;Behavioral;Body System;Brain;brain health;Brain region;Cell membrane;cell type;Cells;Cerebellum;clinically relevant;Code;Complex;Confocal Microscopy;Data;Dendrites;Dendritic Spines;density;dentate gyrus;Distal;Electrophysiology (science);Engineering;entorhinal cortex;Environment;Exercise;Experimental Designs;experimental study;Family;Family member;Foundations;Gene Expression;Genes;granule cell;Hippocampus;Hour;Human;Immediate-Early Genes;Immunohistochemistry;improved;in vivo;in vivo evaluation;Individual;Knockout Mice;Label;laser capture microdissection;Lateral;Lead;Learning;Link;Location;Medial;Mediating;Medical;member;Membrane;Memory;Messenger RNA;Methods;Molecular;Monitor;Moods;Mus;Neoplasm Metastasis;neural;neurological recovery;Neurons;Newborn Infant;novel;novel strategies;Organism;Pattern;Physical Exercise;Physiological;Positioning Attribute;preconditioning;Prevention;Process;promoter;Property;Proteins;Rehabilitation therapy;Reporter;Reporting;RNA;Role;Scientist;segregation;Signal Transduction;Specificity;Stimulus;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Tertiary Protein Structure;Testing;Time;Transcript;transcriptome sequencing;Vertebral column

PROJECT_TITLE: Molecular mechanisms of exercise-induced synaptic plasticity in the hippocampus

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative: Intermediate filaments are abundant cytoskeletal proteins that interact with numerous cellular proteins and contribute to a variety of cellular processes, yet we lack a complete mechanistic understanding of their function. Here we propose to interrogate how intermediate filaments are regulated and how they contribute to inflammation by focusing on the intermediate filament vimentin and its role in neutrophil inflammatory processes and trafficking. The successful completion of this proposal is highly likely to identify new mechanisms by which intermediate filaments contribute to inflammation and to cellular and tissue function.

PI_NAMEs: RUSSO, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: The Role of Intermediate Filaments in Inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: SURGERY

PHR: Project Narrative Genetics researchers have identified tens of thousands of DNA variants that influence risk for human diseases, but identifying the functions of these variants has been challenging. We will develop new approaches to systematically map how many of these variants control particular genes and cell types. Applying these approaches could help to identify new therapeutic targets for an array of common diseases.

PI_NAMEs: ENGREITZ, JESSE M (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Adult;Award;Blood Vessels;Cardiovascular Diseases;career;cell type;Cells;Child;Chromatin;Complex;Computer Models;Coronary Arteriosclerosis;CRISPR/Cas technology;Development;Disease;DNA;Enhancers;Environment;experience;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genomics;Heart;Human body;human disease;Human Genome;human genomics;insight;Leadership;Maps;Measurement;Methods;Molecular;new technology;new therapeutic target;novel strategies;Regulatory Element;Research Personnel;Resolution;Resources;Risk;Role;Science;Surveys;Technology;Testing;tool;trait;Universities;Untranslated RNA;Variant

PROJECT_TITLE: Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types


NIH_SPENDING_CATS: Lymphatic Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE The production of new T cells is controlled in an organ called the thymus. This project will study how the type of vasculature in the thymus contributes to the rapid growth of the organ that occurs in the newborn period. The ultimate goal of these studies is to uncover novel pathways to enhance T cell production in the thymus to improve health by reversing immune deficiencies associated with organ transplant, cancer treatment and aging.

PI_NAMEs: CROOKS, GAY M (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adult;Affect;Age;aged;Aging;angiogenesis;Architecture;Biological Assay;Blood;Blood capillaries;Blood Vessels;cancer therapy;Categories;Cell Compartmentation;Cell Line;Cell Lineage;Cell surface;cell type;Cells;comparative;Complex;Data;Development;Discrimination;Disease;Embryo;Embryonic Development;emerging adult;Endothelial Cells;Endothelium;Event;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Growth;Health;Heart;Hematopoietic;Heterogeneity;Homeobox;Human;Immune Tolerance;Immunity;immunodeficiency;improved;in vivo;Life;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;lymphatic vasculature;lymphatic vessel;Maps;Mediating;Modeling;Morphology;mouse model;Mus;Natural regeneration;Neonatal;neonatal period;neonate;Newborn Infant;novel;Organ;organ growth;Organ Transplantation;Pathway interactions;Phase;Play;podoplanin;postnatal;primary lymphoid organ;Process;Production;Proteomics;rapid growth;receptor;Regulatory T-Lymphocyte;Rejuvenation;Reporter;Reporting;Research Design;Research Proposals;Role;sex;single-cell RNA sequencing;Stromal Cells;Structure;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Thymic epithelial cell;thymic regeneration;Thymus Gland;Time;timeline;trafficking;transcription factor;transcriptome;transcriptomics;trend;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelial Growth Factors;Venous;young adult

PROJECT_TITLE: The Role of lymphatic endothelium in the developing thymus

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE Complex human diseases are jointly influenced by genetic and environmental risk factors. Accurately quantifying the genetic and environmental contribution is key to unveiling the biology and informing novel therapeutics. The proposed study seeks to develop statistical methods to jointly analyze genetic and spatially correlated community-level environmental risk factors for a myriad of diseases of public health significance.

PI_NAMEs: JIANG, BIBO ;LIU, DAJIANG  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: addiction;Air Pollution;Algorithms;biobank;Biology;biomedical informatics;Characteristics;Code;cohort;Communities;Complex;Computer software;Data;Data Aggregation;Data Set;Databases;design;Diabetes Mellitus;Disease;drinking;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Environmental Wind;Etiology;Exposure to;Family;gene environment interaction;Gene Frequency;Genetic;genetic architecture;genetic association;Genetic Models;genetic risk factor;Genetic study;Genome Components;genome wide association study;genome-wide;Genomics;Heritability;Heterogeneity;Human;human disease;improved;Individual;instrument;Insurance;insurance claims;International;Joints;Knowledge;Licensing;Lipids;Location;Long-Term Effects;Meta-Analysis;Methods;Modeling;multi-ethnic;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear Family;Participant;Patient Self-Report;phenome;Phenotype;Plasma;Pollution;Population Control;Privacy;Privatization;Proxy;Public Health;pulmonary function;Regression Analysis;Research;Resource Sharing;risk prediction;Sampling;Smoking;sociodemographics;Speed;Statistical Methods;statistics;Structure;Testing;Therapeutic Intervention;therapeutically effective;tool;trait;Trans-Omics for Precision Medicine;Twin Multiple Birth;whole genome;Work

PROJECT_TITLE: Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative The objective of this application is to develop and evaluate a rapid motion-robust and easy-to-use dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) framework for liver perfusion quantification. This new imaging framework is expected to promote the utilization, efficacy and clinical translation of liver perfusion MRI for improved management of hepatocellular carcinoma (HCC) and other diseases of high clinical impact.

PI_NAMEs: FENG, LI  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Address;Aftercare;analysis pipeline;Biopsy;Breathing;Cancer Etiology;cancer type;care costs;Clinical;clinical implementation;Clinical Research;clinical translation;Consumption;contrast enhanced;Contrast Media;curative treatments;data acquisition;deep learning;deep learning model;Development;Diagnosis;Disease;feasibility testing;flexibility;Gadolinium;Hepatic;Histologic;Image;Image Analysis;image reconstruction;imaging biomarker;Imaging Techniques;improved;Incidence;individualized medicine;ineffective therapies;insight;interest;Kinetics;Learning;Lesion;Liver;Liver diseases;Liver Dysfunction;liver imaging;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Morphologic artifacts;mortality;Motion;motion sensitivity;novel;Operative Surgical Procedures;Pathologic;Patient-Focused Outcomes;Patients;Pattern;Performance;Perfusion;Phase;Prediction of Response to Therapy;prevent;Primary carcinoma of the liver cells;Prognosis;Radial;rapid technique;reconstruction;Recovery;Resolution;response;routine imaging;Sampling;side effect;Signal Transduction;spatiotemporal;Speed;Systemic Therapy;Techniques;Time;tool;Translating;Treatment Efficacy;treatment strategy;tumor;Tumor Angiogenesis;Tumor Burden;tumor microenvironment;United States;Venous;Visual

PROJECT_TITLE: Rapid Motion-Robust and Easy-to-Use Dynamic Contrast-Enhanced MRI for Liver Perfusion Quantification

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Climate-Related Exposures and Conditions;Foodborne Illness;Genetics;Prevention;Skin Cancer

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative There is strong experimental and epidemiological evidence that arsenic in combination with other environmental insults such as ultraviolet radiation (UVR) increases carcinogenesis at even lower arsenic concentrations than the EPA and WHO standard of 10 ppb, suggesting that arsenic is a co-carcinogen in humans. Recent advances in analysis of next generation sequencing have given rise to powerful tools to define distinct mutational signatures in tumors that identify specific defects in DNA repair processes or carcinogenic exposures. This information is useful for cancer epidemiology, basic DNA repair and mutagenesis research, and studies on potential interventions to reduce the mutagenic risk of a specific or mixed exposure that may lead to human cancer.

PI_NAMEs: HUDSON, LAURIE G (contact);LIU, KE JIAN

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Agreement;Animal Model;Arsenic;Arsenites;Biochemical;cancer epidemiology;Cancer Etiology;carcinogenesis;carcinogenicity;Carcinogens;Cell Culture Techniques;Cell model;Cells;Characteristics;Chronic;combinatorial;Complex;Computer Analysis;Data;Defect;Development;DNA Damage;DNA Repair;DNA Repair Gene;DNA Sequence Alteration;drinking water;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Exons;Exposure to;genome sequencing;Histopathology;Human;in vivo;Induced Mutation;insight;Intervention;Introns;keratinocyte;lifestyle factors;Malignant neoplasm of lung;Malignant Neoplasms;Metal exposure;Metals;meter;Molecular;Motivation;Mus;Mutagenesis;Mutation;Mutation Analysis;Mutation Spectra;new technology;next generation sequencing;Nucleotide Excision Repair;Nucleotide Excision Repair Inhibition;Outcome;Outcome Study;Pattern;Persons;Positioning Attribute;predictive modeling;Predictive Value;Prevention strategy;Process;Publishing;repaired;Research;Research Design;Research Personnel;Risk;Safety;Sampling;Skin;Skin Cancer;Skin Carcinogenesis;skin squamous cell carcinoma;Somatic Mutation;Tobacco smoke;tool;Transcription-Coupled Repair;tumor;Ultraviolet Rays;UV induced;UV induced DNA damage;whole genome;World Health Organization;xeroderma pigmentosum group A complementing protein;XPA gene;Zinc;Zinc Fingers;Zinc supplementation

PROJECT_TITLE: Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet Radiation

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Seattle

ORG_NAME: TALUS BIOSCIENCE, INC.

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research aims to develop a technology to enable drug development for gene regulators in cancer. Traditional tools to study these proteins have proven ineffective, so we are developing an in-cell system that specifically tests a drug’s ability to block cancer-causing gene regulators.

PI_NAMEs: FEDERATION, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Address;Binding;Binding Proteins;Biochemical;Biological Assay;Calibration;cancer cell;cancer type;Cell Nucleus;Cells;Child;Chimeric Proteins;Chromatin;Clinical Trials;cofactor;Collaborations;commercialization;Complex;Coupled;Couples;Data;data quality;Development;Digestion;Disease;DNA;DNA Binding;drug candidate;drug development;drug discovery;Drug Targeting;Environment;Experimental Drug Development;Functional disorder;Fusion Oncogene Proteins;Gene Expression;Gene Fusion;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Goals;Human Genome;in vitro activity;Inflammation;inhibitor;Instruction;invention;Label;Length;leukemia;Leukemic Cell;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Mixed-Lineage Leukemia;Modeling;Multiprotein Complexes;National Cancer Institute;Neurologic;Nuclear;Oncogenes;Oncogenic;Organelles;Patients;Peptides;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;prevent;Proteins;Proteome;Proteomics;quality assurance;Recurrence;Regulator Genes;Reporting;Research;response;Sarcoma;Science;screening;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;Sodium Chloride;Specificity;Stimulus;Structural Protein;System;Talus;Technology;technology development;Testing;Therapeutic;Tissues;tool;transcription factor;tumor;Universities;Validation;Variant;Washington

PROJECT_TITLE: Simultaneous pharmacological profiling of oncogenic gene fusion proteins in cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: VILLANOVA

ORG_NAME: VILLANOVA UNIVERSITY

PHR: Project Narrative  Arthritis is a debilitating and painful disease affecting 54 million Americans. This work is aimed at developing a better understanding of the role of the pericellular matrix, a region surrounding chondrocytes, in signaling to the cell how to make enzymes that destroy cartilage and using biomimetic proteoglycans to mitigate the negative consequences. This knowledge may enable minimally invasive strategies for regeneration of cartilage and treatment of early osteoarthritis, a disease state that does not have many options at the current time.

PI_NAMEs: MARCOLONGO, MICHELE S (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;acrylic acid;Adhesions;Affect;aggrecan;aggrecanase;American;Anterior Cruciate Ligament;Arthritis;Attenuated;biglycan;Binding;biomechanical test;Biomimetics;Bovine Cartilage;Calcium Signaling;Cartilage;cartilage degradation;Cartilage Matrix;cartilage regeneration;Catabolism;Cells;Cellular Metabolic Process;Chemicals;Chondrocytes;chondroitin sulfate glycosaminoglycan;Collagen;Collagen Type VI;Cytoskeleton;Degenerative polyarthritis;Deposition;disability;Disease;Early treatment;Engineering;Enzymes;Event;Experimental Designs;Extracellular Matrix;Functional disorder;Gene Expression;Health;Histology;Human;Hydrogels;Immunohistochemistry;In Situ;In Vitro;in vivo;Individual;Infiltration;Inflammatory;interest;Interleukin-1 beta;Intervention;Intra-Articular Injections;Knee;Knowledge;Life;Matrix Metalloproteinases;mechanical properties;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Metabolic;meter;minimally invasive;Mission;Modulus;Molecular;Musculoskeletal Diseases;nanoarchitecture;Nanostructures;Natural regeneration;Operative Surgical Procedures;Organism;Oryctolagus cuniculus;Pain;perlecan;Physiological;Play;Property;Proteoglycan;proteoglycan core protein;Resistance;response;Role;Sepharose;Signal Transduction;Spectrum Analysis;Stimulus;Structure;Testing;Therapeutic Agents;Thick;three dimensional cell culture;Time;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Molecular Engineering of Cartilage PCM Mechanotransduction in Osteoarthritis Using Biomimetic Proteoglycans

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Mental Health;Pediatric;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: Epidemiological evidence shows that paternal lifetime exposures to environmental perturbations, including stress and prior adverse childhood experiences (ACE), are associated with changes in reproductive outcomes, gestational development, and ultimately, offspring health and disease, and animal models have implicated the germ cell transfer of small non-coding RNA (sncRNA), including miRNA, in programming these effects. We recently published our foundational work which allowed us to construct a model to initially assess the composition of, and dynamic changes in, human sperm sncRNA by utilizing complex between- and within-subject comparisons over time. Our hypotheses to test in this proposal are that our prior model built from repeated sampling of a small homogeneous student cohort will replicate in a larger and more diverse population, will predict unique changes in sperm sncRNA when we add subject ACEs to our model, and will substantiate reproductive and developmental importance when miRNA mimics or inhibitors are injected into mouse zygotes.

PI_NAMEs: BALE, TRACY L (contact);EPPERSON, C. NEILL

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Accounting;Adult;adverse childhood events;Animal Model;Biological;Chinese;cohort;Collection;Complex;complex modeling;Conceptions;Data;design;Development;Disease;disease model;early childhood;Embryo;Embryonic and Fetal Development;Environment;Epidemiology;experience;Exposure to;Famines;fetal;General Population;Genetic;Germ Cells;Health;Human;human subject;Immune;In Vitro;in vivo;Individual;inhibitor;insight;Linear Regressions;male;Measures;men;Messenger RNA;Metabolic;Methods;Microinjections;MicroRNAs;model building;Modeling;Mus;novel;offspring;Outcome;Participant;perceived stress;piRNA;Plasma;Population;Population Heterogeneity;Pre-implantation Embryo Development;predictive modeling;Pregnancy;psychiatric symptom;psychologic;Psychological Stress;Publishing;recruit;reproductive;reproductive outcome;response;Role;Sampling;scaffold;Seminal fluid;Signal Transduction;Small RNA;sperm cell;Stress;stress reactivity;stress state;Structure;Students;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;Transfer RNA;Untranslated RNA;Variant;Work;zygote

PROJECT_TITLE: Stress modeling of the human sperm sncRNA transcriptome and causal importance of dynamic miRNA in reproductive and developmental outcomes


NIH_SPENDING_CATS: Biotechnology;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE In patients with sickle cell disease (SCD) improving long-term outcomes of allogeneic hematopoietic cell transplantation (HCT), the only curative option for SCD patients represents an unmet need. In performing HCT in patients with SCD, careful consideration must be given to the conditioning regimen; as the myeloablative total body irradiation (TBI) facilitates full engraftment but it also increases organ toxicities; whereas reduced intensity conditioning (RIC) regimen, is associated with lower organ toxicity but results in higher graft failure/rejection. We propose to develop a paradigm-shifting, highly potent, and safe treatment plan that combines a targeted radiation delivery called “total marrow irradiation” with a thrombopoietin mimetic drug (TPOm) infusion after allogeneic HCT to decrease bone marrow failure and improve engraftment, and potentially protect from further organ damage; resulted from SCD and conditioning regimen.

PI_NAMEs: HUI, SUSANTA K (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acceleration;Adverse event;Affect;Agonist;Allogenic;Anemia;Antibodies;Binding;biological adaptation to stress;Biological Assay;Blood;Blood Vessels;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;C57BL/6 Mouse;Cell Count;Cell Maintenance;cell regeneration;Cells;Chimerism;Chronic;Clinical Trials;clinically relevant;cohort;Collaborations;conditioning;curative treatments;Data;Development;disease model;Dose;Electromagnetic Energy;Endothelial Cells;Engraftment;Erythrocytes;Excision;Flow Cytometry;Functional disorder;Goals;graft failure;Graft Rejection;Hematological Disease;Hematology;hematopoietic stem cell expansion;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hemoglobin AA;Hemolysis;Homing;Hour;humanized mouse;IL3 Gene;image guided;Immunocompetent;Immunofluorescence Immunologic;Immunohistochemistry;improved;Infusion procedures;Inherited;Intervention;irradiation;Leukopenia;Marrow;Measures;mimetics;mouse model;MPL gene;Mus;novel;novel strategies;Organ;Outcome;Patients;Pattern;peptide drug;Peptides;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Pilot Projects;Population;pre-clinical;preclinical study;preservation;prevent;Radiation;radiation delivery;Radiation Dose Unit;Radiation induced damage;radiation mitigation;receptor;Recovery;Regimen;Research;Reticulocytes;Risk;Rodent;Role;Safety;Scalp structure;Sickle Cell Anemia;sickling;Signal Transduction;Stromal Cell-Derived Factor 1;Testing;Therapeutic Intervention;therapeutically effective;Three-Dimensional Image;Thrombocytopenia;Thrombopoietin;Time;Tissues;Toxic effect;translational approach;transplant model;Transplantation;treatment planning;treatment risk;Vascular Endothelial Growth Factor C;Vascular regeneration;Whole-Body Irradiation;Work

PROJECT_TITLE: A Novel Bone Marrow Transplantation Approach for Sickle Cell Disease Using Targeted Marrow Irradiation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Microbiome;Nutrition;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE This project aims to transform microbiome population genetics so that association studies can be performed at the same level of resolution and scale as in human genetics. We will produce a computationally-efficient method for genotyping microbiome species in situ using metagenomics and statistical models for associating microbiome genes with host traits while accounting for microbial population genetic structure. Applying these tools to our deeply phenotyped cohort of ~50,000 individuals, we will test the hypothesis that cardiovascular disease is linked to microbial genes that vary across strains and alter how gut microbes influence human physiology.

PI_NAMEs: POLLARD, KATHERINE S. (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Acceleration;acute coronary syndrome;Address;Algorithms;Alleles;Atherosclerosis;Bacterial Genes;barrier to testing;Benchmarking;bioinformatics tool;Biological Markers;Biology;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cells;Code;cohort;Communities;Complex;Complex Mixtures;computational platform;Copy Number Polymorphism;cost;Country;Data;Data Set;design;Development;Diet;Digoxin;Disease;DNA;drug metabolism;Drug Targeting;Gene Dosage;Gene Family;Gene Frequency;Genes;Genetic;genetic approach;Genetic Recombination;genetic variant;Genetic Variation;Genome;Genotype;Goals;gut microbes;gut microbiome;Haploidy;Health;Heart Diseases;heart function;Home;host-microbe interactions;Human;Human body;Human Genetics;Human Microbiome;In Situ;Individual;Inflammation;insight;Investigation;Israel;Label;Levocarnitine;Life Style;Linear Models;Link;Measurement;Measures;Meat;Mediating;Medical Records;Metabolic;metabolomics;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microorganism;model organism;Modeling;Mutation;novel;open source;Outcome;Pan Genus;Pathway interactions;Pattern;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Physiology;Population;population genetic structure;Population Genetics;prebiotics;precision medicine;Prevention;Probiotics;Process;Research;Resolution;Running;Sampling;Shotgun Sequencing;Shotguns;simulation;Single Nucleotide Polymorphism;Statistical Models;Structure;Taxonomy;Testing;therapeutic target;tool;trait;United States;Unmarried person;Variant

PROJECT_TITLE: Linking microbiome genetic variants with cardiovascular phenotypes in 50,000 individuals

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: Project Narrative Children with developmental language disorders (DLD, aka specific language impairment), a prevalent pediatric disorder, experience hallmark grammar deficits with life-long impacts on educational and occupational outcomes. While effective and early interventions can mitigate the impact of DLD, not enough is known about the neural basis of DLD in young children, yet is needed to inform the design of more individualized interventions. This project uses neuroimaging, along with behavioral methods, with the goal of better understanding the memory- language mechanisms that underlie grammar learning and impairment, while also considering their association to treatment-related changes in preschoolers with DLD.

PI_NAMEs: WASHINGTON, KARLA N (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 5 year old;Address;Adult;Aftercare;age group;Basal Ganglia;behavior measurement;Behavioral;behavioral response;boys;Brain region;Businesses;Cerebellum;Child;Childhood;Clinical;computer assisted patient care;Data;Decision Making;design;Development;Diagnosis;Diffusion;Disease;Early Intervention;Eating;Education;effective intervention;efficacious intervention;efficacious treatment;Elements;Enrollment;evidence base;experience;follow-up;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Image;Impairment;improved;Individual;Inferior;insight;Intervention;knowledge base;Language;Language Development;Language Development Disorders;language impairment;Learning;learning network;Maintenance;Mediating;Memory;Methods;Motor Cortex;neural;Neurobiology;Neurodevelopmental Disorder;neuroimaging;neuromechanism;novel;Nursery Schools;Occupational;Outcome;Paper;peer;Performance;Population;Preschool Child;Prevalence;procedural memory;Process;randomized controlled design;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Personnel;Role;Semantics;Social isolation;Social outcome;specific language impairment;Structural defect;support network;System;Temporal Lobe;Testing;therapy design;tool;Treatment outcome;Unemployment;Washington;Work

PROJECT_TITLE: Neuroimaging Reveals Treatment-Related Changes in DLD: A Randomized Controlled Trial

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Data Science;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease, and environmental exposures are hypothesized to play a role in disease pathogenesis. Our goals are to identify how these exposures that contribute to ALS disease risk relate to and influence the genetic, epigenetic, metabolic, and immune features that are also associated with ALS. Importantly, the discovery of new disease mechanisms will support the development of improved diagnostic, prognostic, and therapeutic approaches; thus, our study may have wide-ranging implications on ALS disease prevention and treatment.

PI_NAMEs: BATTERMAN, STUART A;FELDMAN, EVA LUCILLE (contact);GOUTMAN, STEPHEN ;SARTOR, MAUREEN AGNES

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Acceleration;Address;Air Pollution;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Area;Award;Biological Markers;C9ORF72;Cell Survival;Classification;cohort;Complex;Data;Data Science;Data Set;Development;Diagnostic;differential expression;Disease;disorder prevention;disorder risk;DNA;Drug Targeting;effective therapy;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Exposure to;FDA approved;Gene Combinations;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic Risk;Genetic study;Genome;Genomics;Goals;Grouping;Heritability;Immune;Immunophenotyping;improved;individualized prevention;Inflammasome;Inflammation;innovation;insight;Intervention;Link;Measures;Messenger RNA;Metabolic;metabolome;metabolomics;Metals;methylome;MicroRNAs;middle age;Modeling;Modification;multiple omics;Nature;Neurodegenerative Disorders;new therapeutic target;novel strategies;Occupational;Parkinson Disease;Pathogenesis;Pathway interactions;Patient Self-Report;Patients;personalized medicine;personalized strategies;Persons;Pesticides;Pharmaceutical Preparations;Phenotype;Plasma;pollutant;polygenic risk score;Population;Populations at Risk;Precision Health;predictive modeling;Prevalence;prevent;Prevention;Prevention strategy;prognostic;Public Health;Quantitative Trait Loci;Recording of previous events;Research;Resolution;Risk;Risk Factors;Science;Series;Techniques;Therapeutic;therapeutic target;toxicant;transcriptome;transcriptomics;treatment strategy

PROJECT_TITLE: Developing novel strategies for personalized treatment and prevention of ALS: Leveraging the global exposome, genome, epigenome, metabolome, and inflammasome with data science in a case/control cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project narrative Nearly all known proteins adopt a single folded structure, but human XCL1 defines a new class of fold-switching, or metamorphic, proteins. We seek to understand how and why this fold-switching protein evolved from a non-metamorphic ancestor, and to develop tools to create new metamorphic proteins. This new knowledge will improve human health by enabling the design, discovery and targeting of metamorphic proteins with biomedical utility.

PI_NAMEs: VOLKMAN, BRIAN F (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Adopted;Affinity;Animals;antimicrobial;beta pleated sheet;Binding;Biological;Biological Models;Biomedical Technology;biophysical properties;Breathing;Categories;Cell surface;Chemicals;chemokine;chemokine receptor;Chemotaxis;Computing Methodologies;Dendritic Cells;design;dimer;disulfide bond;Engineering;Equilibrium;Evolution;experimental study;Extracellular Matrix;Family;flexibility;G-Protein-Coupled Receptors;Glycosaminoglycans;Goals;Health;Human;Immune system;improved;Knowledge;Leukocyte Trafficking;Locomotion;Machine Learning;Maps;Measures;Methods;Molecular Conformation;monomer;Mutation;Nanotechnology;Nature;NMR Spectroscopy;novel;optical sensor;Physics;Physiological;pressure;protein folding;Proteins;receptor;receptor binding;reconstruction;Recording of previous events;Role;Structure;Structure-Activity Relationship;Testing;Thermodynamics;thermostability;tool;XCL1 gene;XCR1 gene

PROJECT_TITLE: Evolution and design of metamorphic fold-switching proteins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Pentameric ligand-gated ion channels are targets of many neuroactive drugs including anesthetics, anti- epileptics, and potentially cognitive enhancers. The novel approaches that we implement in this project will yield fundamental insights regarding the molecular mechanisms of lipid modulation in these channels, which may inform the rational design of new therapeutics that target these channels.

PI_NAMEs: CHENG, WAYLAND WING-LUN (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Anesthetics;anti-epileptic agents;Binding;Biochemical;Biology;Biophysics;desensitization;Fatty Acids;Goals;innovation;insight;Ion Channel Gating;ion mobility;Ligands;Lipid Binding;Lipids;Mass Spectrum Analysis;Mediating;membrane model;Modeling;Modification;Molecular;new therapeutic target;Nootropic Agents;novel strategies;Pectobacterium chrysanthemi;Pharmaceutical Preparations;Phosphatidylglycerols;Phospholipids;programs;rational design;Regulation;Research;Site;Specificity;Steroids;Structural Models;Synaptic Transmission;Techniques;Vision

PROJECT_TITLE: Lipid Modulation of Ligand-Gated Ion Channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]