NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Patient Safety;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE These studies seek to understand the impact of fibrosis on therapeutic responsiveness to radiation therapy in pancreas cancer.

PI_NAMEs: DENARDO, DAVID G (contact);KIM, HYUN ;SCHWARZ, JULIE KRISTINA

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-Dimensional;Adjuvant;Antigens;Breast Cancer therapy;cancer type;Cell Death;Cell Hypoxia;checkpoint therapy;Clinical Data;Clinical Trials;Collagen;curative treatments;Data;density;Desmoplastic;Diagnosis;Disease;disorder control;DNA Double Strand Break;Dose;Drug Delivery Systems;efficacy study;Excision;Extracellular Matrix;Fibroblasts;Fibrosis;Focal Adhesion Kinase 1;Genetically Engineered Mouse;Goals;Image Analysis;Immune;Immuno-Chemotherapy;Immunologic Monitoring;Immunotherapy;Impairment;improved;ineffective therapies;Infiltration;Link;lung cancer cell;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;neoplastic cell;non-invasive imaging;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathologic;Patients;Phase I/II Clinical Trial;Play;Population Heterogeneity;pre-clinical;Proliferating;Property;Radiation therapy;Regimen;Resectable;Resistance;response;Role;safety study;safety testing;Shapes;side effect;Signal Transduction;Stromal Neoplasm;Survival Rate;synergism;System;T-Lymphocyte;targeted agent;Testing;Therapeutic;tissue culture;Treatment Efficacy;treatment optimization;tumor;Tumor Immunity;tumor microenvironment;Tumor-Derived;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Targeting Focal Adhesion Kinase to Improve RT-inducted Tumor Immunity

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Tobacco

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE – CORE 002: Adolescent Research Support Core Research on adolescent vaping is critical for developing and testing evidence-based prevention efforts that target population-level changes. However, such research is challenging, as it involves a vulnerable population with many stakeholder interests to consider. The Adolescent Research Support Core will support Project MARVEL’s four integrated research projects by providing efficient procedures, informed by community partners, to facilitate recruitment, retention, and dissemination of findings, while ensuring the protection of adolescent participants.

PI_NAMEs: WAGONER, KIMBERLY G. (contact)

PROJECT_TERMS: Academy;Address;Adolescence;Adolescent;Affect;Annual Reports;Area;Attitude;Behavior;Behavioral;behavioral health;Belief;Child;Collaborations;Communities;community engaged research;community engagement;community partners;Complex;Consent;County;Data;Data Collection;Development;dissemination strategy;Drug abuse;Emotional;Enrollment;Ensure;evidence base;experience;follow-up;Goals;Guidelines;Health;high school;High School Student;Individual;Information Resources;Infrastructure;innovation;interest;Laboratories;Laboratory Study;Language;Life;Mission;multidisciplinary;North Carolina;Parental Consent;Parents;Participant;patient engagement;Pediatrics;Personal Satisfaction;Persons;Population;Prevalence;Prevention;Prevention strategy;Procedures;Process;Protocols documentation;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;retention rate;Risk Assessment;school district;Schools;Services;Students;Substance abuse problem;success;Surveys;Target Populations;Testing;Time;Tobacco use;Training;Translating;Translations;vaping;Vulnerable Populations;Youth

PROJECT_TITLE: Core 2 - ARSC


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Historically, many Veterans had to travel long distances to VA Medical Centers to be evaluated for and undergo kidney or liver transplantation. The ongoing implementation of the MISSION Act will allow a large number of Veterans to undergo kidney or liver transplantation and receive post-transplant care in non-VA transplant centers closer to their homes. Our study will examine how the MISSION Act has changed where Veterans receive transplant care (i.e., within VA or Community Care) and whether the site of transplant care affects how long they wait for a transplant, their likelihood of receiving an organ, and their health following transplantation. We will also explore the perceptions of Veteran patients, VA providers and administrators on the facilitators and barriers to Veterans’ use of VA for transplant care. Information gained from this study will help the VA adapt its transplant program to enhance Veterans’ treatment experiences and enable Veterans to choose the site of transplant care that optimizes their long-term health.

PI_NAMEs: WEISBORD, STEVEN  (contact)

PROJECT_TERMS: Accountability;administrative database;Administrator;Affect;Alcohol abuse;Allografting;Budgets;Caring;Cessation of life;Chronic;Code;cohort;Communities;Community Healthcare;Congresses;Data;data warehouse;Decision Making;design;Diabetes Mellitus;Dual Enrollment;Eligibility Determination;End stage renal failure;Enrollment;evidence base;experience;Failure;Health;Health Resources;Health Services Accessibility;Hepatitis;High Prevalence;Home;Hypertension;improved;innovation;insight;Institution;Insurance;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Lead;Life;Life Expectancy;Link;Liver diseases;liver transplantation;Medical center;medical specialties;Medicare;Methodology;military veteran;mortality;novel;Office Surgery;operation;Organ;Organ Transplantation;Outcome;Patients;Pattern;Perception;Policies;post-transplant;Process;process improvement;programs;Provider;Quality of life;Regression Analysis;Research;Resource Allocation;Risk;Sampling;Services;Site;Source;Statutes and Laws;Structure;System;Time;transplant centers;Transplant Recipients;transplant registry;Transplant Surgeon;Transplantation;Transplantation Surgery;Travel;trend;United Network for Organ Sharing;Veterans;Veterans Health Administration;Waiting Lists;Work

PROJECT_TITLE: Patterns, Processes, and Outcomes of Kidney and Liver Transplantation in an Era of Enhanced Community Care for Veterans

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance Neurons in the developing auditory system that will process similar frequencies of sound exhibit highly correlated activity before hearing onset; however, the role of this activity in shaping the development of brain circuits involved in hearing is not yet known. This proposal will test the hypothesis that correlated neuronal and astrocyte activity induces functional refinement of sound processing circuits to enable acoustic discrimination. This knowledge may provide insight into how disruptions of cochlear function early in life lead to hearing impairment and identify new strategies to improve the performance of cochlear implants.

PI_NAMEs: BERGLES, DWIGHT E (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acoustics;Action Potentials;Acute;Adult;Astrocytes;Auditory;Auditory area;auditory discrimination;Auditory system;Behavioral;Brain;Calcium;Cells;Cochlea;Cochlear Implants;Compensation;Coupling;critical developmental period;Development;Discrimination;DNA Sequence Alteration;electrical property;Electrophysiology (science);Event;Excitatory Synapse;Exhibits;experience;Exposure to;Expression Profiling;Frequencies;Genetic;Genetic Transcription;Hearing;hearing impairment;Image;improved;in vivo;in vivo imaging;Inferior Colliculus;Inner Supporting Cell;insight;Knowledge;Lead;Life;Mediating;Membrane;Midbrain structure;Monitor;Morphology;mouse model;Mus;neuronal circuitry;neuronal excitability;neuronal patterning;Neurons;neurotransmission;ototoxicity;Output;Pattern;Performance;Peripheral;Pharmaceutical Preparations;preservation;Process;Property;reconstruction;Role;Sensory;Shapes;Signal Induction;Signal Transduction;sound;sound frequency;Specific qualifier value;spiral ganglion;Stereotyping;Structure;Supporting Cell;Synapses;Testing;tool;Training;Trauma;two-photon

PROJECT_TITLE: Spontaneous activity in the developing auditory system


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE – CORE 003: Biomarkers and Product Evaluation Core The effects of e-cigarettes on adolescent health are largely unknown. The success of this program project depends on the analysis of e-cigarette and tobacco exposure biomarkers to confirm product use and toxicant exposure in this population. Services provided by this Core to projects in this program will contribute to understanding of changes in exposure and biological effect.

PI_NAMEs: MURPHY, SHARON E (contact)

PROJECT_TERMS: 2-butenal;Acetylcysteine;Acids;Acrolein;Acrylonitrile;Adolescent;adolescent health;Aerosols;Benzene;Biological;Biological Markers;biomarker validation;Body Fluids;Carcinogens;Characteristics;Cigarette;cigarette smoking;Cohort Studies;Cotinine;Cytochrome P450;Data;Dinoprostone;Dose;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Evaluation;Exposure to;F2-Isoprostanes;Goals;Health;hydroxycotinine;indexing;Individual;Individual Differences;Inflammation;Life;Liquid substance;Measurement;Measures;Metabolic;Metabolism;Methods;Minnesota;multidisciplinary;Nicotine;nicotine exposure;nicotine use;non-smoker;oxidation;oxidative damage;Oxidative Stress;Participant;Pathway interactions;Persons;Phenotype;Plasma;Population;programs;Property;Protocols documentation;Reporting;Research;Risk Assessment;Saliva;saliva sample;Salivary;Sampling;Sensitivity and Specificity;Services;Smoker;Standardization;success;Sum;Technology;Time;tobacco exposure;tobacco products;tobacco toxicant;Tobacco use;Tobacco-Associated Carcinogen;toxicant;Toxicant exposure;Universities;urinary;Urine;vaper;vaping;vapor;Visit;Volatilization

PROJECT_TITLE: Core 3 - Biomarkers and Product Evaluation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK BLOOD CENTER

ORG_STATE: NY

PHR: Narrative Vaccines are efficient measures to prevent infections, a critical problem is that aging-associated changes in the immune system lead to decreased immunogenicity and clinical efficacy of most currently used vaccines; novel strategies that increase vaccination efficacy and specifically target the aged immune system are imperative. An essential facet of these efforts is the use of combinatory adjuvants that synergistically potentiate more effective vaccine-induced immune responses against various pathogens. Our goal is to deliver a novel, efficacious combination of innate cytoplasmic PRR adjuvants with rASP-1, a unique parasite protein adjuvant, that promotes protective long-lived adaptive responses and boosts efficacy of vaccines in aged populations.

PI_NAMEs: LUSTIGMAN, SARA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Adult;age related;aged;aging population;aging related;Agonist;Anti-viral Response;Antibody Response;Antigens;asparaginase;Automobile Driving;B-Lymphocytes;Biochemistry;Bioinformatics;Biological Assay;Biology;Bone Marrow;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Cellular Immunology;clinical efficacy;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;CXCL10 gene;CXCR3 gene;Cytoplasm;Data;Dendritic Cells;Engineered Gene;Engineering;Ensure;Genes;Goals;healthy aging;Helminths;Helper-Inducer T-Lymphocyte;Human;human model;immune activation;Immune response;Immune signaling;Immune system;Immunity;immunogenicity;Immunologics;Immunology;immunoregulation;immunosenescence;in vivo;Individual;induced pluripotent stem cell;Infection prevention;influenza infection;influenza virus vaccine;Interferon Type I;Interferons;Interleukin-10;knockout gene;Lead;Ligands;lymph nodes;Measures;Memory;microbial;Modeling;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Nature;novel;novel strategies;old mice;Older Population;Onchocerca volvulus;Parasites;pathogen;Pathway interactions;Pattern recognition receptor;Peptides;Proteins;Receptor Cell;Recording of previous events;recruit;Regulatory Pathway;response;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Societies;Structure of germinal center of lymph node;synergism;T cell response;T-Lymphocyte;Testing;TLR7 gene;transcriptomics;type I interferon receptor;Up-Regulation;Vaccination;vaccine efficacy;vaccine immunogenicity;Vaccines;vaccinology

PROJECT_TITLE: Restoring age-dependent vaccine unresponsiveness by a novel ASP-1 adjuvant combination


ORG_CITY: BROOKLYN

ORG_NAME: VA NEW YORK HARBOR HLTHCARE/SYS/BROOKLYN

PHR: Glaucoma describes a group of optic neuropathies that lead to progressive and irreversible vision loss and frequent blindness. An increase in intraocular pressure (via reduced outflow facility) is a major modifiable risk factor. Although tissue plasminogen activator (tPA) is known to play a key role in regulating outflow facility and thus IOP through non-enzymatic activity, the long-term use of an enzymatically inactive tPA has not been tested for efficacy in preventing functional visual loss and safety. The purpose of this proposal is to directly answer this question and further elucidate this pathway with a goal of developing a new therapeutic aimed at reducing high IOP to prevent functional loss in glaucoma.

PI_NAMEs: DANIAS, JOHN  (contact)

PROJECT_TERMS: Adolescent;Adverse effects;Affect;Alteplase;Animals;Aqueous Humor;Axon;Binding;Blindness;Cell Count;Cellular Morphology;Chronic;Development;Disease;efficacy evaluation;efficacy testing;Electroretinography;Endothelial Cells;Extracellular Signal Regulated Kinases;Eye;Facility Regulation;functional loss;Gelatinase B;Gene Mutation;Glaucoma;Goals;Health;Histology;Human;improved;in vivo;LDL-Receptor Related Protein 1;Life;Link;Lipoprotein Receptor;MAPK3 gene;Measures;Mediating;Minority;modifiable risk;Molecular;Monitor;mutant;Mutation;myocilin;Nerve Degeneration;novel therapeutics;Open-Angle Glaucoma;Optic Nerve;optic nerve disorder;overexpression;Pathology;Pathway interactions;Pattern;Personal Satisfaction;pharmacologic;Physiologic Intraocular Pressure;Play;preservation;prevent;Prevention;Proteins;receptor;response;Retina;Retinal Ganglion Cells;retinal toxicity;Risk;Risk Factors;Role;Safety;Serine Protease;Signal Transduction;Site;Steroids;Supplementation;Testing;Therapeutic Uses;Time;Tissues;Toxic effect;Transgenic Animals;Transgenic Mice;Up-Regulation;Variant;Veterans;Vision;Visual Acuity

PROJECT_TITLE: Tissue plasminogen activator for the treatment of glaucoma

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative: Vascular, thrombotic, and inflammatory diseases, such as sepsis, heart attack or stroke, will affect most of us at some point in life, with a profound impact on the quality and duration of life thereafter. Available therapeutic solutions are limited and mortality rates remain unacceptably high. Guided by the beneficial cytoprotective effects of activated protein C in a broad range of in vivo injury and disease models, the proposed studies will identify novel molecular mechanisms and investigate novel approaches for potential therapeutic applications using engineered molecular biologics.

PI_NAMEs: MOSNIER, LAURENT OLIVIER (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 2019-nCoV;ACE2;activated Protein C;activated protein C receptor;Affect;Agonist;Animals;Anti-Inflammatory Agents;Antibodies;Anticoagulants;Antiinflammatory Effect;Bacterial Infections;Basic Science;Biological Products;Blood;Blood coagulation;Blood Vessels;Brain;Cell surface;cell type;Cells;Cellular biology;chemokine;Circulation;Clinical Trials;Coagulants;Coagulation Process;Collection;COVID-19;COVID-19 complications;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;cytokine;Cytoprotection;Death Rate;Defense Mechanisms;design;Development;Diagnostic;disabled;Disease;disease model;efficacy testing;encryption;Endothelium;Engineering;Epithelium;Equilibrium;F2R gene;Feedback;Fibrin fragment D;Functional disorder;Funding;Generations;Goals;Homeostasis;Host Defense;Human;Immune;Impairment;improved;In Vitro;in vivo;Inflammation Mediators;Inflammatory;Injury;innovation;insight;Ischemic Stroke;Kidney;Knowledge;Life;Liver;Lung;Mediating;mimetics;Modeling;Molecular;Mus;mutant;Myocardial Infarction;novel;novel strategies;Organ;Outcome;PAR-1 Receptor;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Peptide Signal Sequences;Peptides;peptidomimetics;pharmacologic;Physiological;Plasma;pre-clinical;Process;protective effect;Protein C;Proteinase-Activated Receptors;Reaction;receptor;receptor function;Receptor Signaling;Regulation;Resistance;Role;SARS-CoV-2 infection;Sepsis;Serine Protease;severe COVID-19;Signal Pathway;Signal Transduction;Stroke;Structure;Structure-Activity Relationship;Symptoms;System;Testing;Therapeutic;Therapeutic Effect;thromboinflammation;Thrombosis;Tissues;translational potential;Translational Research;Translations;Treatment Efficacy;Variant;Vascular Diseases;Virus Diseases

PROJECT_TITLE: Structure-function of cytoprotective coagulation proteases and their receptors

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Firearms Research;Pediatric;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Firearm injuries are the second leading cause of death for U.S. children and teens (age 1-17) and constitute a major public health crisis requiring urgent attention from the scientific community. Advances in our understanding of this public health problem and the evidence-based solutions needed to reduce both morbidity/mortality and the substantial health disparities associated with firearm injury have lagged other fields of pediatric injury science due to a lack of federal research funding and the absence of a critical mass of trained research scientists. This new T32 application addresses the critical need to develop a scientific workforce that can capitalize on the recent expansion of federal research funding by establishing the nation’s first program dedicated exclusively to providing post-doctoral research training on the prevention of firearm injuries among children and teens.

PI_NAMEs: CARTER, PATRICK M. (contact);ZIMMERMAN, MARC A

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TITLE: Firearm Safety Among Children and Teens (FACTS): Multi-Disciplinary Research Training Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of how intermediate filaments use specific molecular mechanisms to regulate human tissues is ultimately expected to generate therapeutic targets for multiple human diseases. Intermediate filaments are mutated or dysregulated in over eighty human diseases, as well as have involvement in the pathogenesis of human cancers. Thus, by connecting molecular mechanisms to human disease pathogenesis and to pharmacological discovery, the proposed research is relevant to the part of NIH’s mission that concerns the development of fundamental knowledge that will help extend healthy life and reduce burdens of illness.

PI_NAMEs: BUNICK, CHRISTOPHER GERARD (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Aromatic Amino Acids;Automobile Driving;Binding;Biochemical;Biological Assay;Biology;biophysical analysis;burden of illness;Calorimetry;Cell Adhesion;cell motility;Cells;Cellular biology;Clinical;clinically significant;Complex;Coupled;Crystallography;Cutaneous;Cytoplasm;Cytoskeleton;Data;desmoplakin;Desmosomes;Development;Diagnostic;Disease;Electron Microscopy;Epidermis;Face;fibrous protein;filaggrin;Filament;Genes;Goals;Hair;Health;Human;human disease;human tissue;Impairment;innovation;Intermediate Filament Proteins;Intermediate Filaments;Keratin;Knowledge;Lamins;Learning;Length;Life;light scattering;Macromolecular Complexes;Malignant Neoplasms;Mechanics;Migration Assay;Mission;Molecular;Molecular Target;Mutagenesis;Mutate;Mutation;Nail plate;Negative Staining;new therapeutic target;novel;Pathogenesis;Pathologic;Patients;Peptides;pharmacologic;Play;prevent;Prevention;Process;Productivity;protein complex;protein structure;Proteins;Public Health;Regulation;Research;Resolution;Role;Signal Transduction;Skin;skin barrier;Skin Cancer;skin disorder;Stratum corneum;structural biology;Structure;Surface;System;targeted treatment;Testing;Therapeutic;therapeutic target;Tissue Polypeptide Specific Antigen;Tissues;Titrations;tool;Transfection;Translations;United States National Institutes of Health;Vimentin;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular function of an intermediate filament assembly mechanism in epidermal protein complexes and cell migration

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: We will study the physiological functions of astrocytes in the basal ganglia striatal circuitry. Our data will provide new information on the roles of astrocytes in the normal healthy brain and in diseases of the nervous system, including the processes that lead to the development of neurological disease. Our work is also highly relevant to all forms of brain damage and to a diverse range of brain disorders.

PI_NAMEs: KHAKH, BALJIT  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adult;Astrocytes;Award;Basal Ganglia;Biology;Blood Vessels;Brain;Brain Diseases;Brain Injuries;Cells;Central Nervous System;Corpus striatum structure;Data;Databases;Development;Disease;Environment;Evaluation;Excision;excitotoxicity;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Functional disorder;Glues;Goals;Homeostasis;in vivo;insight;Ions;Laboratories;Maintenance;Mental disorders;Molecular;Nervous System Disorder;neural;neural circuit;Neurobiology;Neuroglia;Neurons;Neurosciences;Neurotransmitters;neurovascular coupling;next generation;novel;novel therapeutics;operation;Physicians;Physiological;Process;programs;Regulation;Research;Resources;Role;Scientist;Signal Transduction;Synapses;Synaptic Transmission;synaptogenesis;Testing;Therapeutic;tool;Training;Withdrawal;Work

PROJECT_TITLE: Fundamental astrocyte biology in intact neural circuits


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOLOGY

ORG_NAME: LEHIGH UNIVERSITY

PHR: Project Narrative: The proposed research will impact human health by providing new insights into the role of inner ear organization in refinement of properties expressed by auditory neurons in the brain. These insights will be informative for optimizing therapeutic approaches to early hearing loss or cochlear hypoplasia that aim to preserve normal structure and function of the brain. The proposed experiments address questions fundamental to the mission of the National Institute on Deafness and other Communication Disorders, by investigating processes of both normal and disordered auditory development.

PI_NAMEs: BURGER, R. MICHAEL (contact)

PROJECT_TERMS: Ablation;Acoustic Nerve;Address;Anatomy;Animals;Apoptotic;Architecture;Auditory;Auditory Physiology;Auditory system;Basilar Papilla;biophysical properties;Biophysics;Birds;Bone Morphogenetic Proteins;Brain;Brain region;Brain Stem;Cell Nucleus;Central Nervous System;Characteristics;Chick;childhood hearing loss;chordin;Cochlea;cochlear development;Cochlear nucleus;critical period;Cues;Data;deaf;deafening;deafness;Dependence;Development;Ear;Early Intervention;Electrophysiology (science);Embryo;Epithelium;Exhibits;experimental study;Failure;Frequencies;Genetic;genetic manipulation;Goals;Hair Cells;Health;Hearing;hearing impairment;hearing preservation;Hearing problem;Human;innovation;insight;Intervention;Investigation;Ion Channel;juvenile animal;Knowledge;Labyrinth;Mammals;Maps;Methods;Mission;Modeling;Molecular;morphogens;Morphology;National Institute on Deafness and Other Communication Disorders;nerve supply;neural;neural patterning;neurodevelopment;neuron loss;Neurons;otoconia;overexpression;Pathway interactions;Pattern;Peripheral;Phenotype;Physiology;Population;preservation;Process;Property;Research;response;Role;Sensory;Signal Transduction;sound;Source;Structure;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Work

PROJECT_TITLE: Developmental Determination of Central Auditory Physiology by the Inner Ear

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The primary cilium acts as the cell’s antenna, with recent evidence suggesting that it is critical to the cell’s ability to respond to signals, such as insulin signaling, that are relevant to the development of diabetes. However, we do not yet know if changes in genes important to ciliary function increase a person’s risk to develop diabetes, nor do we understand how ciliary genes act in the cell to affect insulin signaling. Using a combination of genetic and molecular techniques, this proposal seeks to answer these questions to advance our knowledge of cilium biology, open new avenues for patient risk assessment, and identify novel therapeutic targets for common diseases, like diabetes, with huge public health burdens.

PI_NAMEs: DRIVAS, THEODORE GEORGE (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Address;Affect;Award;biobank;Bioinformatics;Biological;Biological Assay;Biology;blood glucose regulation;Body mass index;Candidate Disease Gene;career;Caring;Cell model;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Cilia;ciliopathy;Clinic;Clinical;Code;cohort;Complex;Coupled;Data;Data Set;Development;Diabetes Mellitus;diabetes risk;Diet;Disease;disease model;disease phenotype;Doctor of Philosophy;Electronic Health Record;Explosion;Foundations;Functional disorder;Gene Expression;General Population;Genes;Genetic;Genetic Diseases;genetic variant;Genetic Variation;Genomics;Glucose;Glycosylated hemoglobin A;Goals;human disease;Human Genetics;Impairment;Individual;Institution;Insulin;Insulin Receptor;insulin signaling;Investigation;knock-down;Knock-out;Knowledge;Link;live cell imaging;Medicine;Mendelian disorder;Mentorship;Methodology;Microscopy;Modality;Modeling;Molecular;Mutation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Organelles;Pathogenesis;Pathology;Pathway interactions;Patient risk;Patients;Pediatric Hospitals;Pennsylvania;Persons;Pharmaceutical Preparations;phenome;Phenotype;Philadelphia;Physicians;Positioning Attribute;Postdoctoral Fellow;Public Health;rare variant;Receptor Signaling;Research;Resources;response;Risk;Risk Assessment;Role;Scientist;Secure;Signal Pathway;Signal Transduction;Solid;Structure of ciliary processes;Syndrome;Techniques;Testing;trafficking;Training;transcriptome sequencing;Universities;Variant;Work

PROJECT_TITLE: The role of the primary cilium in insulin signaling and common disease pathogenesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Low frustration tolerance and uncontrolled aggression are common and impairing symptoms in psychiatric disorders as varied as PTSD, bipolar disorder, and autism. Little is known, however, about the neural basis of these behaviors. This proposal uses cutting-edge technologies to reveal the neural circuits underlying frustration and aggression, with the ultimate goal of developing more effective therapies for patients across multiple disorders.

PI_NAMEs: ESHEL, NEIR  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Advisory Committees;Affect;Aggressive behavior;Agitation;Anger;Animals;autism spectrum disorder;Behavior;Behavioral inhibition;Behavioral Paradigm;Biological Assay;Bipolar Disorder;Calcium;career;career development;clinically relevant;conditioning;Diagnostic;Disease;Disparate;Dopamine;Dopamine Receptor;dopaminergic neuron;dorsal raphe nucleus;effective therapy;Electrophysiology (science);Environment;Event;expectation;experimental study;Extinction;Fellowship;Female;Fiber;Frustration;Future;Goals;Growth;Head;Human;Image;Impairment;insight;Link;male;Medicine;Mental disorders;Mentors;Mentorship;motivated behavior;mouse model;Mus;National Institute of Mental Health;neural;neural circuit;Neurobiology;neuromechanism;Neuromodulator;Neurons;Neurosciences;news;Nucleus Accumbens;optogenetics;Outcome;Patients;Phase;Photometry;Positioning Attribute;Post-Traumatic Stress Disorders;prevent;Process;Psychiatry;Psychological reinforcement;Publications;Research Domain Criteria;Research Personnel;response;reward processing;Rewards;Rodent;Role;Serotonin;Shapes;Signal Transduction;Social Behavior;Symptoms;Technology;Testing;Time;Training;translational research program;Ventral Tegmental Area;Violence;Viral;ward;Work

PROJECT_TITLE: Neural circuits of frustration

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Mental health, which accounts for a significant percentage of the global health burden, can be effectively managed through mobile and digital tools, yet suffers from limited access, inconsistent treatments, and qualitative approaches that do not scale. Taking aim at an increasingly pervasive and canonical mental health problem, autism, we plan to build a game-based solution that can treat (addressing issues social interaction, eye contact, and social-emotional awareness, among other things) while tracking progress, and that can automatically generate computer vision libraries for deep learning models that permit enhanced diagnostic feature extraction in the future.

PI_NAMEs: WALL, DENNIS PAUL (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: 8 year old;Accounting;Address;Age;Agreement;Algorithms;Android;Anger;Animals;applied behavior analysis;Artificial Intelligence;artificial intelligence model;autism spectrum disorder;autism symptoms;autistic children;automatic data capturing;Awareness;Behavior;Behavior Therapy;burden of illness;Caring;Cellular Phone;Child;Childhood;Classification;Clinic;Clinical;Complement;computer generated;Computer software;Computer Vision Systems;convolutional neural network;cost;crowdsourcing;Data;data library;Data Science;deep learning;deep learning model;deep neural network;design;Detection;Development;Devices;Diagnostic;digital tool;disability;Disease;Distributed Systems;Dose;Emotional;Emotions;Enrollment;Eye;Face;Family;feasibility testing;feature extraction;Feedback;Forehead;Foundations;Frequencies;Frustration;Future;gaze;Gestures;global health;Happiness;Healthcare;Healthcare Systems;Home;Hour;Human;Image;image archival system;improved;Incidence;Individual;Informatics;innovation;interest;invention;joint attention;Label;Language;Learning;Left;Libraries;Life;Liquid substance;Manuals;marine;Measures;Mental Health;Methods;mHealth;Modeling;Motivation;neural network;neuropsychiatric disorder;neuropsychiatry;novel;Outcome;Parents;Performance;Periodicals;personalized care;personalized diagnostics;personalized health care;Phenotype;Play;Process;prototype;repository;sensor;social;Social Behavior;social communication;social contact;social engagement;Social Interaction;social reciprocity;Socialization;Speed;success;Symptoms;System;Telephone;Testing;tool;Training;training data;treatment effect;treatment response;Waiting Lists;Work

PROJECT_TITLE: A Mobile Game for Domain Adaptation and Deep Learning in Autism Healthcare


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Neuropsychiatric disease often impairs human cognitive and social capabilities arising from the evolutionary expansion of the human neocortex. A major roadblock to interpreting the effect of genetic variants increasing risk for neuropsychiatric disease is that they almost entirely fall into non-coding regions of the genome that regulate gene expression. Here we develop and apply experimental approaches to functionally interrogate gene regulatory elements in discrete aspects of human cortical development to gain new insights into the underlying mechanisms of these disorders that may serve to develop therapeutics.

PI_NAMEs: DE LA TORRE-UBIETA, LUIS  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Adult;Affect;ATAC-seq;Atlases;Automobile Driving;Biochemical;Biological;Biological Assay;Brain;brain size;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Chromosome Mapping;CISH gene;Code;Cognition;Cognitive;CRISPR interference;CRISPR/Cas technology;Data;Development;Disease;Engineering;Enhancers;Equilibrium;Evolution;Excision;Experimental Models;falls;FGFR2 gene;Gene Expression;Gene Expression Regulation;gene regulatory network;gene repression;Gene Targeting;Genes;Genetic Determinism;genetic variant;Genetic Variation;Genome;genomic variation;Genomics;Human;Human Development;Impairment;insight;Length;Libraries;LYN gene;Macaca;Maps;Mass Spectrum Analysis;Methodology;Molecular;Morphogenesis;Mus;Neocortex;nerve stem cell;neurogenesis;Neuroglia;Neurons;neuropsychiatric disorder;next generation sequencing;novel;Nuclear;Nucleic Acid Regulatory Sequences;Outcome;Phenotype;Pregnancy;progenitor;programs;Proliferating;promoter;Protein Isoforms;Proteins;Proteomics;Radial;Reading;Regulatory Element;Research Personnel;Resolution;Risk;Role;single cell ATAC-seq;social;spatiotemporal;Specificity;stem cell differentiation;Structure;Technology;Testing;Therapeutic;Tissues;transcription factor;transcriptome;Untranslated RNA;Validation;Work

PROJECT_TITLE: Defining gene regulatory networks driving cortical evolution and brain development

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: Decatur

ORG_STATE: GA

PHR: Electronic health record (EHR) and clinical registry data are commonly used for monitoring hospital surgical quality. Clinical registry data, like the VA Surgical Quality Improvement Program (VASQIP), are robust because they are hand abstracted by trained personnel, but the time and costs associated with data collection limits hospital performance evaluation to only a sample of all cases performed. Hybrid data (i.e.: EHR combined with clinical registry variables) is an alternative that could increase the number of cases used for measuring hospital performance (providing a more comprehensive picture of the quality of surgical care) and lower the burden of data collection for quality improvement. This mixed-methods proposal will evaluate the reliability of VASQIP’s current case sampling strategy for identifying outlier VA hospitals, explore the use of hybrid data as a means of enhancing data collection efficiency, and will identify how more efficient data collection could enhance local QI through semi-structured interviews with Surgical Quality Nurses.

PI_NAMEs: MASSARWEH, NADER NABILE (contact)

PROJECT_TERMS: Address;Affect;Caring;Clinical;Collection;comparative effectiveness;cost;Data;data access;Data Adjustments;Data Collection;data platform;data registry;Data Sources;data warehouse;Death Rate;Electronic Health Record;Eligibility Determination;Ensure;Evaluation;expectation;Goals;Hand;Hospital Mortality;hospital performance;Hospitals;Human Resources;Hybrids;improved;informant;Infrastructure;innovation;Institution;Interview;Link;Manuals;Measures;Methodology;Methods;Mind;Modeling;Monitor;Morbidity - disease rate;mortality;novel;Nurses;Observational Study;Occupations;Office Surgery;Operative Surgical Procedures;Outcome;Patients;Performance;Perioperative;perioperative morbidity;perioperative mortality;Postoperative Complications;Postoperative Period;practice setting;Predictive Value;Private Sector;programs;prospective;Provider;Quality Indicator;Registries;Reporting;Research;Resources;Risk Adjustment;Safety;Sampling;Structure;success;Time;Training;United States Department of Veterans Affairs

PROJECT_TITLE: Enhancing the Efficiency of Data Collection for Surgical Quality Improvement

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Microbiome;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE When people get infected with viral infections like SARS-CoV-2 and influenza, some get very sick while some barely notice their symptoms. The goal of this project is to support research that will help us understand if this variation in patients’ susceptibility to severe disease is explained by differences in the microbiome (the microbial communities living on and in our bodies). The project will also support the development of a training program at the University of Michigan for junior investigators interested in conducting patient-oriented research related to the microbiome, critical illness, and lung disease.

PI_NAMEs: DICKSON, ROBERT PICKETT (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: 2019-nCoV;Acute;American;Antibiotics;Area;Attenuated Vaccines;Award;Bacterial DNA;Biological;Bleomycin;Blood;Blood specimen;career;Career Mobility;Cells;Cessation of life;Clinical;Collaborations;Communication;Communities;community living;comorbidity;COVID-19;COVID-19 patient;Critical Care;Critical Illness;Dedications;density;Development;Development Plans;Disease;Education;experimental study;Faculty;Fellowship Program;Functional disorder;Goals;gut bacteria;gut microbiota;healthy volunteer;Heterogeneity;Hospitalization;Human;human model;Hypoxemic Respiratory Failure;Immune;immune activation;Immune response;Immunity;Immunologics;Immunology;Immunophenotyping;indexing;Influenza;influenza infection;Influenza vaccination;interest;Intestinal permeability;Journals;Leadership;Leukocytes;Lung;Lung Diseases;lung injury;lung microbiota;Manuscripts;Measurement;Measures;Mechanical ventilation;Medical Students;Medicine;Mentors;Mentorship;Metabolic;metabolomics;Metagenomics;Methodology;Michigan;microbial community;Microbiology;microbiome;microbiome research;microbiota;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;modifiable risk;Morbidity - disease rate;mortality;multidisciplinary;Multiple Organ Failure;Nasopharynx;next generation;Nose;novel;Organ;Oropharyngeal;oropharyngeal swab;Outcome;Oxygen;participant enrollment;Pathogenesis;patient oriented;patient oriented research;patient variability;Patients;Persons;Pharyngeal structure;pharyngeal swab;Phenotype;Physicians;Plasma;Predisposition;Prevention;prognostic;programs;prospective;Proteomics;Publications;recruit;Rectum;Reporting;Research;research and development;Research Methodology;Research Personnel;Research Support;respiratory;respiratory microbiota;respiratory virus;responsible research conduct;Risk Factors;Role;SARS coronavirus;SARS-CoV-2 infection;Scientist;Secure;severe COVID-19;Severities;skills;Source;Specimen;Supervision;Swab;Symptoms;Therapeutic;therapeutic target;Time;timeline;Training;Training Programs;translational medicine;Translational Research;Universities;Upper respiratory tract;Variant;Ventilator;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Midcareer Investigator Award in Patient-Oriented Research in the Microbiome and Lung Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric;Physical Activity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Implementation of evidence-based physical activity approaches in schools remains a challenge limiting their reach and effectiveness. This study will develop and examine the feasibility of using an implementation strategy for active learning, an evidence-based approach to promote children's physical activity in schools. Developing and testing an implementation strategy for active learning is critical to support the scale-up of these approaches and maximize the public health impact.

PI_NAMEs: WALKER, TIMOTHY JAMES (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Active Learning;Address;Adult;aged;American Heart Association;Back;Bayesian Method;Behavioral;boys;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;career;Child;Childhood;Competence;Data;Development;Dissemination and Implementation;early childhood;Education;Effectiveness;effectiveness evaluation;elementary school;Ensure;evidence base;experience;Feasibility Studies;Funding;Generations;girls;Goals;Guidelines;Health Benefit;implementation barriers;implementation fidelity;implementation research;implementation science;implementation strategy;improved;innovation;Intervention;intervention mapping;kohl;Learning;Literature;Maintenance;Mathematics;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;Movement;multilevel analysis;novel;novel strategies;Personal Satisfaction;Physical activity;Physical Education;physical inactivity;population based;prevent;Public Health;Quasi-experiment;Reading;Recommendation;Reporting;Research;Research Activity;Research Personnel;Resources;scale up;school district;Schools;sedentary;skills;Statistical Methods;Students;teacher;Testing;Texas;theories;Time;Training;United States;Work;Youth

PROJECT_TITLE: Developing And Testing An Implementation Strategy For Active Learning To Promote Physical Activity In Children

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Lung;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Respiratory dysfunction is a common, often fatal, symptom of many developmental and genetic disorders such as sudden infant death syndrome (SIDS) and Rett syndrome. Abnormal breathing likely arises from impaired signaling through the neural circuits that control breathing. This proposal is aimed at understanding the molecular mechanisms of respiratory neural circuit assembly in an attempt to identify novel therapeutic targets for breathing disorders.

PI_NAMEs: MOORE, MATTHEW THOMAS (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Air;Amyotrophic Lateral Sclerosis;Automobile Driving;Behavior;Bilateral;Birth;Breathing;Cadherins;Cell Adhesion Molecules;Cell Nucleus;Characteristics;Complex;conditional knockout;Data;Development;developmental disease;differential expression;Disease;driving force;Electrophysiology (science);Embryo;Exhibits;experimental study;Family;Gene Expression;Genes;Genetic Diseases;genetic manipulation;Genetic Models;hindbrain;Homeobox;Homeodomain Proteins;Impairment;improved;In Situ Hybridization;Label;Life;Mammals;Medulla Oblongata;Methodology;Molecular;Motor;Motor Neurons;mouse model;Mus;Muscle;Muscle Contraction;Nervous System;neural;neural circuit;neurodevelopment;Neurons;new therapeutic target;novel;Plethysmography;Population;preBotzinger complex;prevent;progenitor;Respiration;Respiration Disorders;respiratory;Respiratory Diaphragm;Respiratory distress;Respiratory physiology;Rest;Retina;Rett Syndrome;Role;Signal Transduction;Specific qualifier value;Spinal Cord;Structure of phrenic nerve;Sudden infant death syndrome;Symptoms;synaptogenesis;Synaptophysin;Techniques;Testing;Tidal Volume;transcription factor;transcriptome sequencing;Transgenes;Viral;Visual

PROJECT_TITLE: Molecular Mechanisms of Respiratory Circuit Connectivity


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PHR: Project Narrative Creating a more diverse workforce is critical to the future of research in the field of demography and economics of aging, health, and health care. The Get Experience in Aging Research Undergraduate Program (GEAR UP) aims to support and develop talented students from underrepresented backgrounds seeking research careers in this field.

PI_NAMEs: COE, NORMA B (contact);KOHLER, HANS-PETER ;WERNER, RACHEL M

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accounting;Address;Adult;Affect;Aging;aging population;aging related;Alzheimer's disease related dementia;Award;baby boomer;Behavioral Research;Biomedical Research;Black Populations;care providers;career;career development;Clinical;Clinical Research;Collaborations;Communities;Country;COVID-19;Creativeness;Dedications;Demographer;Demography;Diverse Workforce;Economics;Elderly;Epidemiology;Equity;ethnic disparity;ethnic health disparity;ethnic minority;evidence base;Exclusion;experience;Faculty;Funding;Future;Goals;Health;health care delivery;Health Care Research;Health Disparities Research;health disparity;health disparity populations;health economics;Health Policy;Health Services;Health Services Research;Health system;Healthcare;Hispanic Populations;human old age (65+);improved;Income;Individual;innovation;Life Cycle Stages;Life Expectancy;Long-Term Care;Longevity;low and middle-income countries;Mentors;Methodology;Minority;Morbidity - disease rate;mortality;mortality disparity;older adult;peer;Politics;Population;Population Heterogeneity;Population Research;Populations at Risk;programs;Quality of Care;racial determinant;racial disparity;racial health disparity;racial minority;Research;Research Infrastructure;Research Personnel;Research Training;response;skills;social;Societies;socioeconomic development;STEM field;Students;Talents;Time;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;United States;University resources;Woman


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases

PHR: Project Narrative This project is focused on obtaining basic knowledge about protein-protein interactions that are responsible for the beneficial, protective activities of the enzyme, activated protein C, which can provide multiple activities that reduce damage to cells and tissue. Based on preclinical studies in animals, activated protein C shows beneficial, often mortality reducing effects in the settings of ischemia/reperfusion injury of the heart, kidney and lungs, ischemic stroke, graft vs. host disease, kidney transplant, inflammatory lung injury, gastrointestinal inflammatory diseases, pseudomonas lung infection, acute neurotrauma, pancreatic islet transplantation, diabetes, and severe whole-body radiation. Thus, new knowledge about activated protein C variants may lead to improved 2nd or 3rd generation biologics for man.

PI_NAMEs: GRIFFIN, JOHN H;MOSNIER, LAURENT OLIVIER (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: 2019-nCoV;Abbreviations;Acids;activated Protein C;activated protein C receptor;Acute;Address;Affect;Age;Alteplase;Animals;Anticoagulants;Apoptosis;Biological;Biological Products;Blocking Antibodies;Blood coagulation;Blood Coagulation Disorders;Carboxypeptidase U;Cardiovascular Diseases;cell injury;cell type;Cells;Cessation of life;Chronic;citrate carrier;Clinic;clinical development;Coagulation Process;Collection;comorbidity;COVID-19;COVID-19 complications;COVID-19 treatment;Cytoprotection;Data;Databases;Defense Mechanisms;Development;Diabetes Mellitus;Disease;Endothelium;Engineering;enzyme activity;F2R gene;Factor V;Factor X;Feedback;Fibrinolysis;Future;gastrointestinal;Gene Modified;Generations;graft vs host disease;Heart Injuries;Homeostasis;Host Defense;Hyperactivity;Hypertension;Immune;Immune Cell Suppression;immunothrombosis;improved;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Injury to Kidney;insight;Integrins;Ischemia;Ischemic Stroke;Islets of Langerhans Transplantation;ITGAM gene;ITGB2 gene;Kidney Transplantation;Knowledge;Laceration;Libraries;Life;Liver;Lung infections;lung injury;Macrophage-1 Antigen;man;Mediating;Modeling;Molecular;mortality;Mus;mutant;Nervous System Trauma;novel;Organ;Outcome;PAR-1 Receptor;Pathology;Pathway interactions;Peptide Hydrolases;pharmacologic;Plasma;Plasminogen Activator Inhibitor 1;Play;pre-clinical;preclinical study;Process;Protein C;Protein C Inhibitor;protein protein interaction;Protein S;Proteinase-Activated Receptors;Pseudomonas;Reaction;Reagent;receptor;Recombinants;Regulation;Reperfusion Injury;Role;SARS-CoV-2 infection;Sepsis;Serine Protease;severe COVID-19;Shock;Signal Induction;Signal Transduction;Specificity;success;Symptoms;System;targeted treatment;Testing;Therapeutic;thromboinflammation;Thrombomodulin;Thrombophilia;Tissues;tool;Translating;translational potential;Translations;Trauma;trauma induced coagulopathy;Trypsin;Variant;Whole-Body Irradiation

PROJECT_TITLE: Regulation of Protein C Pathways

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative The overall goal of this program is to improve outcomes in the treatment of human leukemias with more effective and less toxic therapies. We will employ novel methodologies and approaches to develop therapeutics that degrade proteins that are essential to leukemia cells, target signaling pathways in specific genetic subgroups, and modulate the apoptotic threshold of leukemia cells. Following pre-clinical studies in common model systems, the most promising therapeutic combinations will be tested in clinical trials with deep molecular characterization of patient samples.

PI_NAMEs: EBERT, BENJAMIN LEVINE (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Academia;Acute Myelocytic Leukemia;analog;Apoptotic;BCL1 Oncogene;BCL2 gene;bench to bedside;Biological;Biological Assay;Biological Models;Biology;CBL gene;Clinic;Clinical;clinical database;Clinical Investigator;Clinical Research;clinical trial implementation;Clinical Trials;Collaborations;Correlative Study;design;Development;Disease;DNA Sequence Alteration;Drug Combinations;drug development;effective therapy;experience;FDA approved;FLT3 gene;Funding;Genetic;Genetic Databases;Goals;Heme;Human;human model;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;Joints;Laboratories;Laboratory Study;lenalidomide;leukemia;leukemia treatment;Leukemic Cell;Malignant Neoplasms;Mediating;member;Methodology;Methods;Mitochondria;Molecular;mouse model;mutant;Mutation;novel;novel therapeutic intervention;novel therapeutics;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;preclinical study;predicting response;Prediction of Response to Therapy;Predisposition;Private Sector;Productivity;programs;protein degradation;Protein Isoforms;Proteins;Proteomics;Publications;Qi;Research;Research Personnel;response;Sampling;Science;Signal Pathway;Signal Transduction;Somatic Mutation;Structural Biochemistry;structural biology;Subgroup;success;synergism;Testing;Thalidomide;Therapeutic;therapeutic candidate;therapeutic development;therapeutic target;transcription factor;Translations;ubiquitin ligase;ubiquitin-protein ligase;Work;Xenograft Model;Xenograft procedure;Zinc Fingers

PROJECT_TITLE: Development of Novel Therapeutic Strategies in Human Leukemias


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE Accurate non-invasive optical measurements of cerebral hemodynamics require suppression of confounding contributions from superficial tissue (scalp, skull, etc.) and motion artifacts. This project aims to develop an optical technique that minimizes these confounding contributions, thus paving the way for a more effective assessment of brain function and neurovascular pathologies. A wearable device, also developed in this project, will further extend this optical technique to point-of-care diagnostics.

PI_NAMEs: FANTINI, SERGIO  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Arachnoid mater;Biological;Biomedical Engineering;Blood flow;Blood Vessels;Blood Volume;Brain;Brain imaging;brain tissue;Breast;cerebral hemodynamics;cerebral oxygenation;Cerebrum;Clinical;clinical application;Cognitive;cognitive task;cognitive testing;Collection;Complex;computerized data processing;cost;cost effective;cranium;Data;Dedications;design;detector;Development;Devices;Diagnostic;diagnostic tool;Diffuse;diffuse optical spectroscopy and imaging;Diffusion;Dura Mater;Effectiveness;fabrication;Fatty acid glycerol esters;flexibility;Frequencies;Functional Imaging;Generations;Geometry;hemodynamics;Human;human subject;Image;improved;in vivo;instrument;instrumentation;Lasers;Light;Mammary Gland Parenchyma;Mammography;Measurement;Measures;Methods;microchip;microsystems;Monitor;Monte Carlo Method;Morphologic artifacts;Motion;Muscle;Near-Infrared Spectroscopy;neurovascular;Noise;novel;novel strategies;Optics;Oxygen Consumption;Oxygen saturation measurement;Pathology;Performance;performance tests;Phase;Play;point of care;point-of-care diagnostics;Prefrontal Cortex;Property;Research;Research Project Grants;Role;Scalp structure;Scheme;signal processing;Signal Transduction;Silicon;simulation;Skeletal Muscle;Skin;solid state;Source;Specificity;Spectrum Analysis;Stroke;Subarachnoid Space;subcutaneous;Surface;System;Techniques;Technology;Telemetry;Testing;Theoretical Studies;theories;Time;Tissues;Walking;wearable device;wireless;wireless communication

PROJECT_TITLE: Dual-slope method for enhanced depth sensitivity in frequency-domain near-infrared spectroscopy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PHR: Project Narrative While we have seen several exciting new drugs receive approval for treatment of acute myelogenous leukemia (AML) in the last couple of years, most patients with AML still die of their disease. We propose to expose actual patient leukemia cells to candidate drugs, and then measure which drugs cause cell death signaling, to choose active drugs for AML patients. Our overall goal is to establish a novel strategy by which a patient's AML sample can be tested to identify the best drugs with which to treat that patient.

PI_NAMEs: LETAI, ANTHONY G (contact)

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Age;Apoptosis;Apoptotic;Azacitidine;base;BCL-2 Protein;BCL1 Oncogene;BCL2L1 gene;BH3 peptide;Biological Assay;Biostatistics Core;Cell Death Signaling Process;Cell Membrane Permeability;cell type;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical predictors;Clinical Treatment;Clinical Trials;Collaborations;Cytarabine;Cytogenetics;Data;Dependence;Development;Diagnosis;Disease;Dose;drug candidate;experimental study;Exposure to;Genetic;Genetic Determinism;Genomics;Goals;Heterogeneity;Homologous Transplantation;Hour;Human;in vivo;Individual;individual patient;inhibitor;innovation;Laboratories;leukemia;leukemia treatment;Leukemic Cell;MCL1 gene;Measurement;Measures;Methods;mimetics;Mitochondria;Molecular;myeloblast;Neoadjuvant Therapy;novel;novel strategies;novel therapeutic intervention;novel therapeutics;outcome prediction;Outer Mitochondrial Membrane;Output;Pathology;patient derived xenograft model;Patients;Peptides;Persons;Pharmaceutical Preparations;Phenotype;pre-clinical;predicting response;Prediction of Response to Therapy;predictive marker;predictive tools;Proteins;Proteomics;Regimen;response;Sampling;Series;Signal Induction;Signal Transduction;small molecule;success;targeted treatment;Testing;Therapeutic;Time;tool;transcriptomics;Validation;Vidaza;Work

PROJECT_TITLE: Directing AML therapy with BH3 profiling


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE Mutations in the CBL gene are common in leukemia, but there are currently no therapies specifically for patients with mutations in this gene. CBL mutations create opportunities for targeted therapy because these mutations lead to activation of signaling pathways that can be inhibited by FDA-approved drugs. We will identify the pathways that are activated when CBL is mutated, characterize the biology of these mutations, and test candidate therapies for CBL-mutant leukemia.

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;AKT Signaling Pathway;Alleles;Binding;Binding Proteins;Biochemistry;Biology;CBL gene;Cell Line;Cell Proliferation;Cells;Chronic Myelomonocytic Leukemia;clinical efficacy;clinical translation;Complement;Complex;CRISPR screen;CSF2RB gene;CUL5 gene;Cullin Proteins;Dasatinib;Development;drug development;Drug Targeting;Dysmyelopoietic Syndromes;efficacy testing;experimental study;FDA approved;Feedback;FLT3 gene;Functional disorder;gain of function;Genes;genome-wide;Genotype;Goals;Hematopoiesis;Human;In Vitro;in vivo;in vivo Model;individualized medicine;kinase inhibitor;Laboratories;Lead;leukemia;Leukemic Cell;leukemogenesis;LYN gene;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Missense Mutation;Modeling;Molecular;mutant;Mutate;Mutation;Myeloproliferative disease;novel therapeutic intervention;Pathway interactions;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Phosphotransferases;PI3K/AKT;PIK3CG gene;Play;Point Mutation;preservation;Proliferating;Protein Kinase;Protein Tyrosine Kinase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Receptor Protein-Tyrosine Kinases;Recurrence;Role;Series;Set protein;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;src-Family Kinases;targeted treatment;Testing;Therapeutic;therapeutic target;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Validation;validation studies

PROJECT_TITLE: Targeted aberrant signaling in CBL-mutant leukemia


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Despite historic advances in the treatment of acute leukemia, acute myeloid leukemia (AML) remains a poor prognosis diagnosis for adult and pediatric patients and defines an area of significant unmet medical need. Mutations that drive leukemia development frequently lead to alteration of genes encoding proteins that control gene expression, leading to corruption of normal blood development programs and leukemia. Thus, we propose an innovative strategy integrating chemical and leukemia biology to target aberrant gene transcription by (a) characterizing and developing therapeutic agents targeting zinc finger transcription factors and (b) by revealing functionally validated therapeutic targets for further therapeutic discovery and development.

PI_NAMEs: ARMSTRONG, SCOTT A (contact)

PROJECT_TERMS: Acute;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affinity;analog;Architecture;Area;Automobile Driving;Biological;Biological Models;Biology;Blood;cancer cell;Cancer Model;Cell Death;Cell Death Induction;Cell Differentiation process;Cell Proliferation;Cells;Chemicals;Childhood;Chimeric Proteins;Chromatin;Clinic;Clinical Trials;Collaborations;Combination Drug Therapy;Creativeness;CRISPR screen;Data Set;Dependence;Development;Diagnosis;Disease;drug discovery;drug-like compound;Epigenetic Process;epigenome;epigenomics;Family;Fusion Oncogene Proteins;Future;Gene Expression;Gene Expression Regulation;Gene Mutation;Gene Rearrangement;Genes;Genetic Transcription;genome-wide;Goals;Hematopoietic;high risk;high throughput screening;Human;immune modulating agents;immunoregulation;in vivo;inhibitor;innovation;insight;interdisciplinary approach;Knowledge;Laboratories;Lead;lenalidomide;leukemia;leukemia treatment;leukemic stem cell;Medical;member;MLL-rearranged leukemia;Modeling;Molecular;mutant;Mutation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;NPM1 gene;Oncogenic;overexpression;Patients;pediatric patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polyubiquitination;pre-clinical;Pre-Clinical Model;Prognosis;Program Development;programs;Property;protein complex;protein degradation;Proteins;Regulatory Pathway;Research;Research Personnel;Role;Science;screening;small molecule;stem cell self renewal;stemness;structural biology;synergism;targeted treatment;Technology;Testing;Thalidomide;Therapeutic;therapeutic development;therapeutic target;transcription factor;Transcriptional Activation;transcriptome;tumor;ubiquitin-protein ligase;Work;Zinc Fingers

PROJECT_TITLE: Biology and therapeutic targeting of zinc finger transcription factors in AML


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The Objectives of our K12 Program are to: (1) recruit and train outstanding Scholars who will be engaged in an individualized curriculum and in mentored health care research during a three-year period in this multidisciplinary, multicultural K12 program, (2) enhance the mentoring environment for translational science Scholars through a robust program for both mentors and mentees built on the NRMN training platform, and (3) provide a highly focused mentored research experience that fosters Scholars' successful transition to independence and continued engagement as leaders of translational health care teams. Meeting these objectives will require continued campus-wide, multidisciplinary participation of faculty as members of mentoring teams for K12 Scholars. Additionally, the ICTS, home of the only CTSA in the State of Iowa, will collaborate with CTSA hubs across the United States to enhance the learning environment and increase the opportunities for our K12 Scholars to build successful careers in translational science.

PI_NAMEs: BASSUK, ALEXANDER G;FERGUSON, POLLY J (contact)

PROGRAM_OFFICER_NAME: CHANG, SOJU

PROJECT_TERMS: Acceleration;Address;Ally;Appointment;Area;Automobile Driving;bench to bedside;care systems;career;Charge;Clinical;clinical care;Clinical Sciences;Collaborations;Communities;Community Services;Dentists;design;Disease Outcome;educational atmosphere;Educational Curriculum;Environment;experience;Faculty;Fostering;Geography;Goals;Health;health care availability;Health Care Research;Health Occupations;Health Personnel;Healthcare;Healthcare Systems;Home;Inferior;Infrastructure;innovation;Institution;Iowa;Medical Care Team;meetings;member;Mentored Clinical Scientist Development Program;Mentors;multidisciplinary;Pharmacists;physical therapist;Population;Postdoctoral Fellow;programs;recruit;Research;Rural;rural area;rural disparities;Rural Population;Science;Scientist;Strategic Planning;System;team-based care;Training;Training Programs;Translational Research;United States;Universities;Urban Population;Work

PROJECT_TITLE: CTSA K12 Program at The University of Iowa


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative With nearly 6 million Americans living with disabilities resulting from a traumatic brain injury, at an estimated annual cost of $90 billion per year, development of an effective neuron replacement strategy could have enormous impact. The proposed research will develop a cell transplantation procedure to replace a specific type of neuron, cortical interneurons, following experimental head injury. Understanding the therapeutic potenital of these newly generated inhibitory neurons is essential before these discoveries can be translated into new therapies for human brain injury.

PI_NAMEs: HUNT, ROBERT F (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Adolescent;Adult;American;Anxiety;Area;Behavior;Behavioral;Behavioral Assay;Benchmarking;Brain;Brain Injuries;Cell Therapy;Cell Transplantation;cell type;Cells;Chronic;Clinic;clinically relevant;Closed head injuries;Cognitive;controlled cortical impact;cost;Craniocerebral Trauma;design;Development;disability;Disease;Electroencephalography;Electrophysiology (science);Embryo;Epilepsy;Fluorescent Antibody Technique;Funding;gamma-Aminobutyric Acid;Generations;Goals;Hippocampus;Human;human pluripotent stem cell;Image;Impairment;improved;In Vitro;induced pluripotent stem cell;inhibitory neuron;Injections;Injury;Interneurons;Laboratories;Light;Long-Term Effects;Maps;Medial;Memory;Memory impairment;migration;Modeling;Monitor;Motor;mouse model;Mus;National Institute of Neurological Disorders and Stroke;nerve stem cell;Nervous System Disorder;neural circuit;neuronal replacement;Neurons;novel therapeutics;optogenetics;Output;patch clamp;Patients;Pattern;Post-Traumatic Epilepsy;Pre-Clinical Model;presynaptic;prevent;Procedures;progenitor;Property;Replacement Therapy;Research;Rodent;Rodent Model;Seizures;side effect;Slice;Source;stem cells;Supportive care;Synapses;synaptic inhibition;TBI Patients;TBI treatment;Technology;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tissues;Translating;Transplantation;Traumatic Brain Injury;Treatment Efficacy;Viral;Visualization;Work

PROJECT_TITLE: Rewiring the Injured Brain with GABA Progenitors

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


PROJECT_TERMS: Administrator;Budgets;Clinical;Communication;Core Facility;Development;Ensure;Funding;Gender;Grant;Human;human subject;IACUC;Institution;Institutional Review Boards;Laboratories;Lead;leukemia;meetings;member;Minority Participation;Monitor;novel therapeutic intervention;operation;Performance;Preparation;Program Research Project Grants;programs;Progress Reports;protocol development;Protocols documentation;Publications;Regulation;Reporting;Research Personnel;Research Project Grants;Schedule;Services;skills;United States National Institutes of Health;Vertebrates;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE This Shared Resource Core will collect blood and/or marrow samples from patients with AML or MDS and preserve viable cells, RNA, and DNA from adult patients receiving treatment at DFCI or BWH, along with annotated clinical and genomic data from these patients. The Core makes these samples available for clinical or research studies carried out in each of the projects in this grant.

PI_NAMEs: GRIFFIN, JAMES DOUGLAS (contact)

PROJECT_TERMS: Adult;Biological Assay;Blood;Bone Marrow;Bone Marrow Diseases;Cell Line;Cell Survival;Cells;Clinical;Clinical Data;clinical investigation;Clinical Research;Clinical Research Protocols;Cryopreservation;Cytogenetics;Dana-Farber Cancer Institute;Data;Databases;Development;Disease;DNA;drug development;Drug Screening;Flow Cytometry;genomic data;Genomics;Grant;Hematologic Neoplasms;Human;In Vitro;in vitro Model;in vivo;Institutional Review Boards;Laboratories;Laboratory Research;Laboratory Study;leukemia;Marrow;Mission;Molecular;Mononuclear;Myeloid Leukemia;novel therapeutic intervention;Oncogenes;participant enrollment;Pathologic;patient derived xenograft model;Patients;pre-clinical;preservation;Prognosis;programs;Protocols documentation;Research;Research Personnel;research study;Resource Sharing;RNA;sample collection;Sampling;Standardization;System

PROJECT_TITLE: Sample Processing and Analysis


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE Alcohol use disorders (AUD) and alcohol-related liver disease (ALD) are major public health problems with substantial and yet rising levels of morbidity and mortality worldwide. The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in AUD and ALD. The TARP is designed to improve clinical treatment of AUD and ALD by increasing the availability of appropriately-trained young scientists who are conversant in basic and clinical sciences and able to comfortably traverse the translational gap between these sciences.

PI_NAMEs: COSGROVE, KELLY P.;VASILIOU, VASILIS  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: alcohol research;programs


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE - Core 2 Biostatistics The goal of Core 2 Biostatistics is to assure that all experiments conducted through this P01 in in myeloid malignancies have access to state-of-the-art statistical support for their design and analysis. This extends to the basic science and murine experiments described in the four Projects, as well as to the clinical and correlative studies undertaken in conjunction with the Clinical Core (Core 3) and the Biospecimen Core (Core 1). This assures that the work performed on this P01 will be robust and reproducible, and thereby contribute to an improved understanding of these diseases.

PI_NAMEs: NEUBERG, DONNA S. (contact)

PROJECT_TERMS: Animals;Basic Science;Biometry;Biostatistics Core;Cells;Clinical;Clinical Research;Clinical Research Protocols;Conduct Clinical Trials;Correlative Study;Data;design;Development;Disease;electronic data capture system;experimental study;Goals;Human;improved;in vivo;Laboratories;Laboratory Research;leukemia;Mus;Mutation;Myeloproliferative disease;New Agents;next generation sequencing;novel therapeutic intervention;Outcome;Patients;prospective;Reporting;Reproducibility;research study;Resources;Retrospective Studies;Sampling;Techniques;Therapeutic;transcriptome sequencing;Work

PROJECT_TITLE: Biostatistics Core


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative The Clinical Research Support Core 3 will support delivery of clinical samples to biospecimen Core 1 under the guidance of Biostatistical Core 2 for performance of relevant assays within all of the projects. Moreover, Core 3 will be responsible for the design and conduct of clinical trials based on science emanating from Projects 1, 2, and 4.

PI_NAMEs: STONE, RICHARD M (contact)

PROJECT_TERMS: Adherence;Adverse event;Aftercare;Age;Ancillary Study;Apoptosis;appropriate dose;Biological Assay;Biology;Biostatistics Core;CBL gene;Cells;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collecting Cell;Collection;Conduct Clinical Trials;Consent;Dasatinib;Data;data management;data quality;Dedications;design;Development;Diagnosis;Diagnostic;Disease;Documentation;early phase clinical trial;Eligibility Determination;Enrollment;Ensure;Ethnic Population;follow-up;Funding;Gender;Goals;Grant;Health Insurance Portability and Accountability Act;high risk;Hospitals;Human;Human Resources;improved outcome;Individual;individual patient;kinase inhibitor;Laboratories;Lead;lenalidomide;leukemia;Leukemic Cell;leukemogenesis;LYN gene;member;Menin;MLL-rearranged leukemia;Modification;Mutation;Myeloid Leukemia;Myeloproliferative disease;novel therapeutic intervention;operation;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Pharmacologic Substance;Physicians;pre-clinical;Proteins;Publications;quality assurance;racial population;recruit;Refractory;Relapse;relapse patients;Reporting;Research;Research Personnel;Research Support;Resources;response;Role;Sampling;Science;Scientist;Specimen;Testing;Therapeutic;Therapeutic Studies;therapeutic target;Time;Tissue Banks;Toxic effect;transcription factor;Translating;treatment program;trial design;Validation

PROJECT_TITLE: Clinical Research Support


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  There is some intriguing evidence that changes in the way older individuals carry out a complex activity of daily living may herald the beginning of cognitive decline. One of these complex activities is driving. We propose testing the ability of the increasingly popular sensors placed in cars to track driver behavior (following too close, drifting out of one's lane, distracted driving) to provide early warnings of cognitive decline, allowing the individual time to seek further testing and treatment and to make plans for the future.

PI_NAMEs: NEWMAN, DAVID ;TAPPEN, RUTH M (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Age;Aging;Algorithms;Alzheimer's Disease;American;Automobile Driving;Awareness;Behavior;Brain;Chronic;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;Complex;Computer software;cost;Data;Databases;Dementia;Detection;Diagnostic;Disease Progression;distracted driving;distraction;driving behavior;Early Diagnosis;Emotional;Enrollment;Evaluation;evaluation/testing;executive function;Exhibits;experience;Family;Future;Gender;Goals;Government;Grouping;human old age (65+);Impaired cognition;indexing;Individual;innovation;interest;Language;Measurable;Measurement;Measures;Medical;Medicare;Memory;Methods;mild cognitive impairment;Modernization;Monitor;older adult;older driver;Older Population;open source;Output;Participant;Performance;Persons;Public Health;recruit;Reporting;Research;Research Project Grants;response;Risk;Safety;screening;screening program;sensor;Services;Societies;Symptoms;System;Techniques;Technology;Testing;Time;Translating;Vehicle crash;Visual attention;Visuospatial;Weather;wellness visit;willingness

PROJECT_TITLE: In-Vehicle Sensors to Detect Cognitive Change in Older Drivers


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The goals of this study are to understand how inhibiting a protein called DNA-PK helps makes tumors more detectable by the immune system and how this protein contributes to enhancing the ability for immune cells to remain an anticancer state longer. These studies can potentially develop more effective cancer immunotherapies.

PI_NAMEs: DAVILA, EDUARDO V (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Adoptive Cell Transfers;anti-cancer;anti-CTLA4;anti-PD-L1 antibodies;Antigens;Binding;Biological Markers;cancer cell;cancer immunotherapy;Cancer Patient;cancer survival;Cell Lineage;Cells;Cellular immunotherapy;Clinical;clinically significant;Data;Dendritic Cells;Detection;DNA;DNA-dependent protein kinase;DNA-PKcs;effective therapy;engineered T cells;Engineering;Frequencies;G22P1 gene;Genetic Transcription;Goals;Head;Histocompatibility Antigens;Human;Immune;immune checkpoint blockade;Immune system;immunogenic;immunogenicity;Immunotherapy;In Vitro;in vivo;Individual;inhibitor;insight;Knock-out;Ligands;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Melanoma;Melanoma Tumor;member;Microsatellite Instability;Molecular;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;neoantigens;novel;oncology trial;patient subsets;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;prevent;Promoter Regions;protein expression;Proteins;research clinical testing;response;Role;Sampling;Signal Transduction;Surface;T cell response;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;therapy design;Transcript;Transcription Repressor;Transcriptional Regulation;tumor;Tumor Antigens;Tumor Expansion;Tumor Immunity;Tumor-Derived;Tumor-Infiltrating Lymphocytes;Vaccines

PROJECT_TITLE: Expanding the tumor antigen landscape and maintaining APCs in a T cell-activating state to restore tumor immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because high-grade serous ovarian cancer is a particularly deadly cancer that is often only identified at late stage and treatment options are limited. Specifically, we pro- pose to use single-cell profiling to identify the biologic basis of subtypes of this disease, because researchers could then develop treatments that target the unique vulnerabilities of each subtype. The proposed work, which identifies the pathway and cell-type basis of these subtypes, are highly relevant to NCI’s mission and particu- larly timely with the advent of single-cell profiling and immunotherapies, which will likely need to be paired with other treatment strategies for large solid tumors such as most high-grade serous ovarian cancers.

PI_NAMEs: DOHERTY, JENNIFER A.;GREENE, CASEY S (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Antibodies;Bar Codes;Biological;cancer cell;Cancer Control;Cancer Etiology;cancer gene expression;cancer subtypes;Cell Fraction;Cell surface;Cell Surface Proteins;cell type;Cells;cohort;Data;Data Set;Disease;disorder subtype;Epithelial ovarian cancer;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic Markers;genome-wide;genomic profiling;Immune;Immunohistochemistry;Immunotherapy;improved;inclusion criteria;Individual;Knowledge;Letters;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Membrane Proteins;Mission;Molecular;molecular subtypes;new technology;Pathway interactions;patient derived xenograft model;Pattern;Population;Population Analysis;primary outcome;Proteins;Public Health;Publishing;Reporting;Research;Research Personnel;Resolution;RNA;Sampling;Serous;single-cell RNA sequencing;Solid Neoplasm;Standardization;Stromal Cells;Survival Analysis;survival prediction;Techniques;Testing;Transcript;transcriptome;transcriptome sequencing;transcriptomics;translational impact;treatment strategy;tumor;Tumor Biology;United States;Variant;Women's mortality;Work;Xenograft procedure

PROJECT_TITLE: Characterization of high-grade serous ovarian cancer subtypes via single-cell profiling

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease

PHR: Project Narrative: Loop diuretics are the most commonly used medications to relieve and prevent fluid and sodium overload in patients with heart failure. Unfortunately, the development of resistance to these agents is common. This study will seek to gain a better understanding of the mechanisms underlying this diuretic resistance.

PI_NAMEs: TESTANI, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TITLE: Mechanisms of diuretic resistance in heart failure

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PITTSBURGH

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The proposed project seeks to explore the development of synthetic molecules that mimic complex protein structures and functions. The public health relevance of the work stems from the potential applications of these molecules as bioactive agents as well as their utility in shedding light on fundamental issues related to natural protein behavior.

PI_NAMEs: HORNE, WILLIAM SETH (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;analog;Area;Award;Behavior;Biological;biomacromolecule;Biomedical Research;Biomimetics;Characteristics;Chemicals;Complex;design;Development;Disease;Engineering;functional group;Goals;Laboratories;Life;Light;mimetics;mimicry;Mutagenesis;National Institute of General Medical Sciences;Nature;Pattern;Peptides;Production;programs;Property;protein complex;protein folding;protein function;protein structure;Proteins;prototype;public health relevance;Research;scaffold;stem;Structure;Tertiary Protein Structure;Vertebral column;Work

PROJECT_TITLE: Exploring the Impact of Altered Backbone Composition on Protein Folding and Function

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Kidney Disease;Nutrition;Obesity;Prevention;Urologic Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Kidney stones are common, costly, and a major cause of morbidity. This proposal will study two mechanisms contributing to high urine oxalate and low urine citrate in kidney stone patients, including high risk obese and post-gastric bypass patients. By elucidating these mechanisms, the results from this study will advance scientific knowledge and improve preventative care.

PI_NAMEs: PROCHASKA, MEGAN L (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: absorption;Acids;Advisory Committees;Affect;Agreement;Alkalies;Alkalosis;Award;bariatric surgery;base;Basic Science;Biological Models;Calcium Oxalate;career development;Chicago;Chronic;citrate carrier;Citrates;clinical care;Clinical Management;clinical practice;Clinical Research;Colon;cost;Creatinine;Crystal Formation;Data;design;Development;Diet;dietary;Disease;Environment;epidemiologic data;Epidemiologic Methods;Epidemiology;Equilibrium;Excretory function;experience;Fatty acid glycerol esters;follow-up;Funding;Future;Gastric Bypass;gastrointestinal;Goals;Healthcare;high risk;Hour;Human;Hyperoxaluria;Impairment;improved;Inflammation;Intervention Studies;Intestinal Absorption;Kidney;Kidney Calculi;Knowledge;Label;Lead;Learning;Link;Malabsorption Syndromes;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Metabolic acidosis;Morbidity - disease rate;Nephrolithiasis;Obesity;Oral;Oxalates;Patient Care;patient oriented;patient oriented research;patient retention;Patient risk;Patients;Permeability;Physicians;Physiology;Plants;Positioning Attribute;potassium citrate;prevent;Prevention;Prevention strategy;Preventive care;primary endpoint;Protocols documentation;Provider;recruit;Research;Research Design;Research Personnel;Risk;Risk Factors;Scientific Advances and Accomplishments;secondary endpoint;Serum;skills;Sodium;Source;Testing;Training;translational study;Treatment Protocols;United States National Institutes of Health;Universities;urinary;Urine

PROJECT_TITLE: Mechanisms of disordered citrate and oxalate excretion in nephrolithiasis

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The primary goal of the proposed research is to leverage existing genetic marker (GWAS) data in large numbers of studies across diverse populations to discover additional genetic loci for cardiometabolic traits, identify important gene-lifestyle interactions, and identify the molecular signatures that underlie the interactions. The investigation will be carried out in approximately 1.267 million European, African, Hispanic, and Asian Ancestry participants. Study results can contribute to enhanced clinical practice.

PI_NAMEs: RAO, DABEERU C (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Accounting;Affect;African;African ancestry;Alcohol consumption;Architecture;Asian;Asian ancestry;biobank;Biological;blood lipid;Blood Pressure;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cigarette;Clinical;clinical practice;clinically relevant;Collaborations;Complex;Coronary heart disease;Data;Detection;Development;Diabetes Mellitus;DNA Methylation;Dyslipidemias;Education;Ensure;Environment;European;European ancestry;Evaluation;Exhibits;Foundations;Freedom;Future;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Risk;genome wide association study;genome-wide;genomic locus;Genomics;Goals;Health;health disparity;Hispanic;Hispanic ancestry;Homeostasis;Hypertension;improved;Individual;insight;Intervention;Investigation;Japan;Joints;Life Style;lifestyle factors;Lipids;Methods;modifiable risk;Molecular;molecular phenotype;Molecular Profiling;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;Multivariate Analysis;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;novel therapeutics;Obesity;Outcome;Participant;Pathway Analysis;Pathway interactions;personalized care;Physical activity;pleiotropism;Population;Population Heterogeneity;Precision Medicine Initiative;Prevention;programs;Psychosocial Factor;Public Health;Research;Research Personnel;Risk;Risk Factors;Sample Size;Sampling;Sampling Studies;Series;sex;sex variable;Site;Sleep;Smoking;Stroke;Study of Latinos;Testing;Therapeutic;tool;trait;Trans-Omics for Precision Medicine;Variant;Veterans;working group

PROJECT_TITLE: A Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic Traits


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Narrative / Relevance Our proposed research is aimed at developing new chemical tools for analyzing the interactions and functions of messenger RNAs in the cell, and applying them to address important biomedical questions. Our new methods will establish easy-to-install chemical handles on large, complex RNAs that allow them to be labeled, tracked, analyzed, and controlled. We will use them to investigate how drugs and metabolites interact with RNAs in the cell, and to study the effects of chemical modifications that are included in mRNA vaccines and upcoming RNA therapies.

PI_NAMEs: KOOL, ERIC T. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Affect;base;Binding Sites;Biology;Biotin;Cells;Chemicals;Clinical;clinically relevant;Complex;Crosslinker;design;Drug Interactions;Engineering;Future;Health;Human;Hydrophobicity;Imidazole;improved;insight;Label;Laboratories;Length;Ligand Binding;Ligands;Light;Mammalian Cell;Maps;Mediating;Messenger RNA;Metabolite Interaction;Methodology;Methods;Modification;Molecular;next generation;next generation sequencing;novel;novel strategies;Pathway interactions;Permeability;Pharmaceutical Preparations;programs;Proteins;Proteome;Reaction;Reagent;Research;Research Personnel;RNA;RNA analysis;RNA Binding;RNA vaccine;secondary metabolite;Site;small molecule;Structure;System;Technology;Therapeutic;Therapeutic Agents;therapeutic RNA;therapeutic target;tool;Toxic effect;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Transcriptome Analysis with RNA-Reactive Probes


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Telehealth

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative The overall purpose of this R01 grant application entitled “Self-Management to Optimize Survivorship Care and Outcomes in Lung and Colorectal Cancer” is to test whether an advanced practice nurse (APRN)-led Survivor Self-Management (SSM) Intervention can improve care coordination, communication, and quality of life in lung and colorectal cancer. In collaboration with the Beckman Research Institute of City of Hope and the University of California, Riverside, we have a unique opportunity to understand whether a self-management and oncology/primary care shared care model can optimize outcomes for lung and colorectal cancer survivors, a growing population that are traditionally underrepresented in cancer research. Completion of the study will improve our understanding on how to best transition lung and colorectal cancer survivors to post-treatment follow-up care.

PI_NAMEs: SUN, VIRGINIA CHIH-YI (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advanced Practice Nurse;Aftercare;Age;American;anti-cancer research;Anxiety;Applications Grants;Appointment;arm;attentional control;California;Cancer Survivor;care coordination;care delivery;care outcomes;Caring;Chronic Care;Cities;Collaborations;Colorectal;Colorectal Cancer;Communication;comorbidity;comparison intervention;Complex;Data;design;Deterioration;Discipline of Nursing;disorder prevention;Disparity;Distress;Dyspnea;Early Diagnosis;Early treatment;efficacy evaluation;efficacy testing;experience;Family;Fatigue;follow-up;Friends;Functional disorder;Future;Geriatric Assessment;Goals;Health Promotion;Healthcare Systems;human old age (65+);implementation facilitators;improved;improved outcome;innovation;Intervention;intervention delivery;Intestines;Knowledge;Long-Term Effects;Lung;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Mental Depression;Modeling;National Cancer Institute;Neuropathy;Oncologist;Oncology;Ostomy;Outcome;Pain;patient oriented;Patients;persistent symptom;personalized care;Population;Price;Primary Care;primary care provider;Process;Provider;provider adoption;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Reporting;Research;Research Institute;Research Priority;Resources;response;Science;Self Efficacy;Self Management;Self Perception;skills;skills training;Specific qualifier value;Survival Rate;Survivors;survivorship;symptom management;symptomatic improvement;Symptoms;telehealth;Testing;treatment arm;treatment effect;Treatment Efficacy;Treatment outcome;Universities;Videoconferencing


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Regenerative Medicine;Vector-Borne Diseases

ORG_CITY: ITHACA

ORG_DEPT: ZOOLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative: In order to successfully transmit disease, mosquitoes must survive midgut invasion by human pathogens, which often causes damage to the mosquito gut epithelium. In model organisms, stem cell-mediated gut epithelial repair has been shown to be essential for host survival of oral infection, however the role of intestinal stem cells in the epithelial infection response of mosquitoes has not been explored. In this proposal, we aim to characterize gut epithelial dynamics in Aedes aegypti under conditions of homeostasis and pathogenic challenge and identify the role of stem cell-mediated midgut repair in mosquito survival of pathogenic invasion.

PI_NAMEs: BUCHON, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acute;Address;Aedes;Affect;Age;Animals;Antimitotic Agents;Area;ATAC-seq;Bacteria;Biology;Black Box;Blood;Cell Differentiation process;cell type;Cells;Cessation of life;Communicable Diseases;Communities;Compensation;Competence;Complex;Culicidae;disease transmission;Drosophila genus;Enterocytes;Enteroendocrine Cell;Epithelial Cells;Epithelial Physiology;epithelial repair;Epithelium;Equilibrium;feeding;Fluorescence-Activated Cell Sorting;gastrointestinal epithelium;Genetic;Genetic Transcription;Goals;Homeostasis;Human;human pathogen;Incubated;Infection;innovation;Intestines;Invaded;Investigation;Knowledge;Longevity;Malaria;marker transgenes;Mediating;microbial;Midgut;model organism;Modeling;mosquito-borne;Natural regeneration;novel;Oral;oral infection;Oral Ingestion;oral pathogen;Outcome;pathogen;Pathogenicity;Pathway interactions;Phenotype;Physiological;Physiology;Play;Population;progenitor;Regenerative response;repaired;Reporting;Research;Resolution;response;Role;single-cell RNA sequencing;stem cell proliferation;stem cells;stemness;Stimulus;Stress;success;Testing;Tissues;tool;transcriptome sequencing;Transgenic Organisms;transmission process;vector;vector control;vector mosquito;Vector-transmitted infectious disease;Vectorial capacity;viral transmission;virtual;Work

PROJECT_TITLE: The role of stem-cell mediated midgut repair in the dynamics of mosquito infections

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]