NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PI_NAMEs: KINCHINGTON, PAUL R. (contact)

PROJECT_TERMS: adenovirus mediated delivery;Adenoviruses;Affinity;Animal Model;Animals;Bacterial Artificial Chromosomes;Baculoviruses;Biological Assay;Biology;Cell Culture Techniques;Cell Line;Cells;Collaborations;Communities;Complex;Core Grant;Dedications;Derivation procedure;design;Development;Disease;DNA;education resources;Equipment;experience;Faculty;fast protein liquid chromatography;Funding;Gene Delivery;Gene Expression;Gene Modified;Gene Silencing;gene therapy;Generations;Genes;Genetic;genetic manipulation;Genetic Materials;Genetic Recombination;Genome;genome editor;Guide RNA;Herpesviridae;Herpesvirus 1;Human Resources;In Vitro;in vivo;Insecta;knock-down;Knock-out;knockout gene;Knowledge;Laboratories;Lentivirus;Mediating;member;Methods;Molecular;Neurons;nucleic acid delivery;Organ;overexpression;Pathogenesis;Pathologic;Plasmids;Play;Preparation;Production;promoter;protein expression;protein purification;Proteins;Recombinants;Research;research faculty;Research Personnel;Resources;RNA;Role;Senior Scientist;Serotyping;Simplexvirus;skills;small hairpin RNA;System;Technical Expertise;Time;Tissues;transduction efficiency;Transfection;vector;Vertebral column;Virus;virus development;Vision;Vision research;Visual;Work

PROJECT_TITLE: Virus Production and Manipulation of Protein/Gene Expression Module


ADMINISTERING_IC: EY

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: CHEN, YUANYUAN  (contact)

PROJECT_TERMS: 3-Dimensional;Biological;Biological Assay;Biomedical Research;Caring;Cell Culture Techniques;Cell Differentiation process;Cell Reprogramming;Cells;Collaborations;Core Grant;Dedications;design;Development;Endothelial Cells;Equipment;Experimental Designs;Eye;Eye diseases;Faculty;Fostering;Gene Modified;Goals;Health;Height;high throughput screening;human induced pluripotent stem cells;Image;imager;improved;induced pluripotent stem cell;Infrastructure;investigator training;Knowledge;Leadership;Liquid substance;Maintenance;Methodology;Modality;monolayer;novel;novel therapeutics;Organoids;Patients;Pharmaceutical Preparations;Process;Productivity;protocol development;Protocols documentation;Reader;Regenerative Medicine;Reporter;Research;Research Personnel;Resources;Retina;screening;Screening procedure;Services;Source;Supervision;synergism;Technology;tissue culture;Tissue Culture Techniques;tissue/cell culture;tool;Training;translational medicine;Vision;Vision research

PROJECT_TITLE: hIPSC-Reprogramming and Cell Culture Module

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (07)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome

PI_NAMEs: ST LEGER, ANTHONY J (contact)

PROJECT_TERMS: advanced analytics;ATAC-seq;Biological Assay;Cell Nucleus;Cell Separation;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Computer software;computerized data processing;Core Grant;cost;Data;data acquisition;Data Analyses;data management;Data Set;design;Development;digital;Disease;DNA;DNA Sequencing Facility;Ensure;epigenetic regulation;Equipment;experience;experimental study;Extracellular Protein;Faculty;Flow Cytometry;Foundations;Funding;Future;Gene Expression Profiling;Generations;Genetic Transcription;Genomics;Goals;Grant;Immune response;in vivo;Instruction;investigator training;large datasets;Libraries;Licensing;Molecular;new therapeutic target;next generation sequencing;novel;Ophthalmology;Population;prediction algorithm;programs;Proteins;Publications;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;RNA;Science;Scientist;Services;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;skills;Sorting;sustainable resource;Systems Biology;Techniques;Technology;Therapeutic;therapy development;Tissue Banks;tissue regeneration;Training;transcriptome sequencing;Vision;Vision research;vision science

PROJECT_TITLE: Systems Biology Module


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Regenerative Medicine

PI_NAMEs: BEHRMANN, MARLENE  (contact)

PROJECT_TERMS: Acceleration;Age related macular degeneration;analytical method;analytical tool;ATAC-seq;Biometry;Blindness;Cell Nucleus;ChIP-seq;Collaborations;Communicable Diseases;Communities;Complex Analysis;complex data;Computer Analysis;Computers;Computing Methodologies;Core Grant;Cornea;Data;Data Analyses;data integration;Data Set;deep learning;design;Development;diagnostic tool;Discipline;Disease;experience;Experimental Designs;experimental study;Eye diseases;Eye Movements;Faculty;Funding;gene therapy;Goals;Human Resources;Improve Access;improved;Individual;Inflammation;innovation;Joints;Learning Module;lectures;Machine Learning;Medical Records;member;metabolomics;Methodology;microbiome;Modernization;Molecular;multiple data types;Natural regeneration;nerve supply;novel therapeutics;ocular microbiome;ocular surface;Ophthalmology;Optic Nerve;Pathology;Pediatrics;Performance;Persons;Pharmacotherapy;Physiological;Postdoctoral Fellow;programs;Prosthesis;Publications;Research;Research Personnel;Retina;Retinal Degeneration;retinal imaging;Scientist;single cell ATAC-seq;Source;Statistical Data Interpretation;Statistical Models;stem cells;Structure;Students;System;Teacher Professional Development;Techniques;Technology;Testing;theories;Tissue imaging;tool;Training;transcriptome sequencing;Universities;Vision;Vision Disorders;Vision research

PROJECT_TITLE: Analytics, BioStatistics, and Machine Learning Module


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pain Research;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Socioeconomically disadvantaged populations have a high prevalence of chronic pain, exacerbated by social isolation, intersectional stigma, and disparities in pain assessment and treatment options. Effective interventions using a multilevel, biopsychosocial approach are needed to decrease the unequal burden of pain. The proposed study will test group-based integrative models of pain management in primary care safety net clinics to improve pain care for racially and ethnically diverse low-income patients.

PI_NAMEs: CHAO, MARIA T (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Acupuncture Therapy;Address;Behavioral;biopsychosocial;care seeking;Caring;chronic pain;chronic pain patient;Clinic;Clinical;clinical care;COVID-19 pandemic;Data;Discrimination;Disparity;Economically Deprived Population;Education;effective intervention;Empathy;ethnic diversity;evidence base;experience;Feeling;Guidelines;health equity;High Prevalence;improved;Individual;individualized medicine;Integrative Medicine;internalized stigma;Intervention;intervention effect;intervention refinement;Intervention Studies;Knowledge;Length;Link;Loneliness;Low income;Low Income Population;Manuals;Mediating;Mediator;Medical;Meditation;member;Mental Depression;Methods;Mind-Body Intervention;Modeling;multimodality;Neighborhoods;Nonpharmacologic Therapy;opioid mortality;opioid overuse;Pain;Pain intensity;Pain interference;Pain management;Pain Measurement;pain model;pain outcome;Pain quality;pain relief;Participant;Patients;Personal Communication;Persons;Phase;Physical Function;post intervention;Preparation;prescription opioid;Primary Care;primary care setting;primary care visit;primary outcome;Procedures;Process;programs;Protocols documentation;Provider;Public Health;Qualitative Methods;Quasi-experiment;racial disparity;racial diversity;racism;Randomized;recruit;Reporting;Research;Research Personnel;Resource-limited setting;Resources;safety net;San Francisco;secondary outcome;Self Efficacy;social;social factors;social health determinants;Social isolation;social stigma;Social support;socioeconomic disadvantage;socioeconomics;Spanish;Spanish/English;Standardization;Stigmatization;Structure;Testing;theories;Time;treatment as usual;Urban Health;Visit;Vulnerable Populations;Yoga

PROJECT_TITLE: Group-based Integrative Pain Management: A multi-level approach to address intersectional stigma and social isolation in diverse primary care safety net patients with chronic pain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Obstructive sleep apnea is a life-threatening condition, disrupting multiple autonomic, mood, breathing, and cognitive functions, most likely from tissue and functional alterations in brain sites that regulate these functions, which are linked to morbidity, mortality, and quality of life. The pathological processes that induce such brain changes in obstructive sleep apnea are unclear, but likely include intermittent hypoxia-induced oxidative stress and mitochondrial dysfunction; those aspects can be evaluated by assessing regional brain temperatures, metabolites, and antioxidant levels, links between temperature, metabolites, and disease severity, as well as examining the effect of continuous positive airway pressure, the gold standard intervention for obstructive sleep apnea, on brain temperature and metabolites. The outcomes will have important implications for identifying effective interventions to rescue brain injury, especially in obstructive sleep apnea patients with non- compliant continuous positive airway pressure or no treatment, with subsequent benefits for dysfunctional physiology and behavior, and could dramatically improve the morbidity, mortality, and quality of life in the condition.

PI_NAMEs: KUMAR, RAJESH  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age;Amygdaloid structure;Anterior;Antioxidants;Apnea;Area;Astrocytes;Axon;Behavior;Brain;brain dysfunction;Brain Injuries;Brain region;brain tissue;Breathing;Cerebellar Cortex;Characteristics;Choline;Cognition;Cognitive;cognitive function;comparison control;Consumption;Continuous Positive Airway Pressure;Creatine;Defense Mechanisms;Diffusion;Dorsal;effective intervention;Energy Metabolism;Equilibrium;FDA approved;Functional disorder;Glutathione;gray matter;Health;Hippocampus;Hour;Human;Hypoxia;Immune;Impairment;improved;Incidence;indexing;Inflammation;Injury;insight;Insula of Reil;Intervention;Knowledge;Life;Link;Mediating;Membrane;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Moods;Morbidity - disease rate;mortality;Myelin;myoinositol;N-acetylaspartate;Neuroglia;neuroinflammation;Neurons;non-compliance;Non-Steroidal Anti-Inflammatory Agents;Obstructive Sleep Apnea;Osmosis;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathologic Processes;Patients;Physiology;Play;Prefrontal Cortex;Process;Production;Proliferating;Quality of life;Reactive Oxygen Species;Regulation;response;Role;Severity of illness;sex;Site;sleep regulation;Source;spectroscopic imaging;Spectrum Analysis;stem;Symptoms;Temperature;tissue injury;Tissues;United States

PROJECT_TITLE: Brain Metabolites and Temperature Changes in Obstructive Sleep Apnea Adults

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research

PHR: RELEVANCE TO PUBLIC HEALTH Acne, the most common human skin disease, is associated with C. acnes, affects over 50 million people in the U.S., and has a significant psychological impact on patients affecting their self-esteem. We seek to understand the mechanisms by which C. acnes phylotypes induce T cell-derived mitochondrial proteins in acne and how these proteins contribute to skin health and homeostasis.

PI_NAMEs: AGAK, GEORGE W (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acne;Acne Vulgaris;Affect;Affinity;anti-microbial peptide;Antigen-Presenting Cells;antimicrobial;Bacteria;Binding;Biological;Carbohydrates;Cell Death;Cell Differentiation process;Cells;Chronic;clinical investigation;Clone Cells;Cutaneous;Data;Defense Mechanisms;Dendritic Cells;design;disability;Disease;DNA;dysbiosis;experimental study;Exposure to;extracellular;Gene Expression Profile;Genes;genetic element;genetic signature;Goals;Grant;Health;Histone H2B;Histones;Homeostasis;Host Defense;Human;IL17 gene;Image;Immune;Immune response;Immunologic Techniques;improved;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innovation;Interferons;Interleukin-10;Journals;keratinocyte;Lesion;Ligands;lipidomics;Lipoproteins;Mass Spectrum Analysis;Mediating;Medical Care Costs;Metagenomics;Microbe;microbial;microbiome;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;monocyte;neutrophil;new technology;Nonlytic;Nucleotides;pathogen;Pathogenesis;Patients;Persons;Play;Proteins;Proteomics;Psychological Impact;Psychological Stress;Public Health;Publications;receptor;response;Role;self esteem;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;skin lesion;Staphylococcus aureus;Stimulus;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;therapeutic target;TLR1 gene;TLR2 gene;TLR6 gene;transcriptomics;Translational Research;whole genome;Work

PROJECT_TITLE: The Role of T cell Extracellular Traps in Acne Pathogenesis


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative This project has the potential to exert a sustained, powerful influence on the field of obesity prevention and health equity by evaluating a highly promising approach to achieve population-level impact on obesity for Black and Latinx youth. Findings from this study will advance knowledge about the role of children’s neighborhood contexts in influencing the impact of parenting-focused intervention to prevent obesity.

PI_NAMEs: URSACHE, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;Adverse event;Affect;Age;Behavior;Black race;Body mass index;Buffers;cardiovascular disorder risk;Caring;Cessation of life;Characteristics;Child;Child Development;Child Rearing;Collaborations;community advisory board;Crime;Data;design;Development;early childhood;early life stress;Education;Environment;Ethnic Origin;evidence base;experience;Exposure to;Face;Family;Focus Groups;food environment;Gender;Green space;health assessment;health equity;healthy weight;high risk;Informal Social Control;Intervention;Intervention Studies;Knowledge;Latinx;Learning;Lived experience;Mental Health;Methods;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Nursery Schools;Obesity;obesity prevention;obesity risk;Outcome;Overweight;parenting intervention;Parents;peer;Personal Satisfaction;physical conditioning;Population;Population Study;Poverty;preadolescence;premature;prevention effectiveness;preventive intervention;Race;racial difference;racism;Randomized;Randomized, Controlled Trials;Recommendation;Restaurants;Role;Sampling;Schools;social;social determinants;stressor;Students;Testing;Time;universal prevention;Variant;Weight Gain;Youth

PROJECT_TITLE: Long-term population-level impact of a school-based parenting-focused intervention to prevent obesity among Black and Latinx children in historically disinvested neighborhoods

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative  Understanding the impact of viral biomolecular condensates on cellular processes, including translation and RNA interference, presents a promising avenue for improving human health. These processes are frequently disrupted during infections by various viral pathogens, offering the possibility of identifying new antiviral targets linked to viral condensate formation or virus-host interactions within these structures.

PI_NAMEs: MAY, JARED PAUL (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Area;Attention;Authorship;Biological Models;Capsid Proteins;career development;Cell Physiology;Cells;doctoral student;epigenetic regulation;Family;fibrillarin;fitness;Foundations;Future;Gene Expression;Health;Homeostasis;Human;improved;Infection;innovation;International;Knowledge;Laboratories;Lead;Link;Manuscripts;Mediating;Membrane;Methodology;Methylation;Molecular;nanopore;novel virus;Nuclear;Organelles;pathogenic virus;pea enation mosaic virus;Physical condensation;Plant Model;Plant Viruses;Process;programs;Proteins;Research;Ribosomal RNA;RNA Interference;RNA Viruses;Role;Small Interfering RNA;Structure;Students;symposium;Testing;Therapeutic;Transcript;transcriptome;translating ribosome affinity purification and RNA-sequencing;Translational Repression;Translations;translatome;Turnip - dietary;undergraduate student;Viral;Virus;virus host interaction;Virus Replication;Vision

PROJECT_TITLE: Dissecting the Impact of Viral Biomolecular Condensates on Cellular Translation and RNA Interference (RNAi)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Many clinically and economically important traits are complex, i.e., they are under the influence of many underlying genes. Understanding how variation in genotype leads to variation in phenotype is a difficult problem as genes often interact with each other, such that knowing the effects of individual genes is not sufficient to predict how they will combine. This project will develop new computational tools for learning from large genotype-phenotype data for humans and model organisms in order to improve our ability to predict phenotype for new genotypes and detect novel gene interactions.

PI_NAMEs: ZHOU, JUANNAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;animal breeding;Bayesian learning;biobank;Biological;Biological Assay;causal variant;Clinical;Complex;Complex Genetic Trait;computational pipelines;Computer software;computerized tools;Data Analyses;Data Set;Databases;design;Development;disorder risk;DNA Sequence;gene interaction;Genes;Genetic;genetic architecture;Genetic Epistasis;Genotype;Goals;high dimensionality;Human;human data;improved;Individual;insight;Learning;Machine Learning;machine learning method;Maps;mathematical model;Methods;model organism;Modeling;Modernization;novel;Organism;Pathway interactions;Performance;Phenotype;phenotypic data;Plants;predictive modeling;programs;Research;Techniques;Technology;Testing;trait;Uncertainty;user-friendly;Validation;Variant;Work

PROJECT_TITLE: Modeling non-additive genetic mechanisms for complex traits

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: Project Narrative Text Mining and Large Language Models to Enhance Functional Annotation in UniProt of Protein Variants Associated with Alzheimer's Disease Hundreds of genetic variants associated with Alzheimer’s Disease (AD) have been discovered, and better understanding of the impact of these variants is key to developing effective strategies for diagnosing, preventing, and treating AD. However, much of the information about AD-related variants is scattered throughout the scientific literature, so it is challenging for AD researchers to find and piece together this knowledge. To address this problem, we will use a combination of custom-built text-mining tools and Large Language Models (e.g., ChatGPT) to automatically extract information about AD-related variants from the literature, and we will present the results in UniProt in a variety of accessible, user-friendly formats.

PI_NAMEs: BATEMAN, ALEX  (contact);WU, CATHY H.

PROGRAM_OFFICER_NAME: PILLAI, AJAY

PROJECT_TERMS: Address;Alzheimer's Disease;Amino Acid Sequence;Automated Abstracting;ChatGPT;Classification;Clinical;Communities;Custom;Data;Diagnosis;Disease;disorder risk;effective therapy;experience;Feedback;Genetic;genetic variant;improved;Individual;interest;Knowledge;knowledge graph;large language model;Learning;Literature;Manuals;member;Modeling;Molecular;natural language;Neurodegenerative Disorders;novel;novel therapeutics;Output;Paper;Performance;Positioning Attribute;prevent;Process;prompt engineering;protein function;protein structure;Proteins;prototype;PubMed;Readability;recruit;Reporting;Research Personnel;Research Support;Resources;Role;Running;Structure;Surveys;System;Text;text searching;tool;user-friendly;Variant;web site;Work

PROJECT_TITLE: UniProt - Text Mining and Large Language models to Enhance Functional Annotation in UniProt of Protein Variants Associated with Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed studies focus on an important, yet understudied area of meningeal biology and dementia research. The overall goal is to improve our understanding of the contribution of meningeal plaque accumulation in cognitive decline, the role that inflammation plays, and the key mechanistic players involved. These studies will further address whether brain trauma plays a causal role in modulating the meningeal milieu, which may support strategies aimed at monitoring meningeal inflammation during aging in prior TBI patients.

PI_NAMEs: THEUS, MICHELLE LEE (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Acceleration;Address;Age;Age Months;Aging;aging population;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid;Amyloid deposition;Area;Arteries;arteriole;Basement membrane;Biology;Blood;Blood Vessels;Brain Injuries;Cells;Cephalic;Cerebral Amyloid Angiopathy;Cerebrovascular Circulation;Cerebrum;Chronic;Cognitive deficits;Data;Dementia;Deposition;Epidemiology;experimental study;Functional disorder;Gene Mutation;Goals;Hemorrhage;Immune;Impaired cognition;improved;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;Ischemic Stroke;J20 mouse;Label;Link;Literature;Macrophage;Mediating;Meningeal;Meningeal Arteries;Meninges;mild traumatic brain injury;Monitor;monocyte;Morphology;Mus;Nerve Degeneration;neuroinflammation;Neurologic;novel;old mice;Paint;parent grant;Pathology;Pattern;Peripheral;Phenotype;Platelet-Derived Growth Factor;Play;prevent;Process;Recovery;recruit;Research;response;Risk;Role;Senile Plaques;sex;single-cell RNA sequencing;Surface;TBI Patients;Techniques;Testing;Trauma;Traumatic Brain Injury;vascular bed;Work

PROJECT_TITLE: Immune-specific EphA4 influence meningeal amyloid accumulation following TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Surveillance for cancer recurrence is a critically important part of CRC survivorship care, as CRC recurrences are common and may be curable if detected early. However, up to 60% of the 1.5 million CRC survivors in the U.S. fail to receive surveillance as recommended by the American Society for Clinical Oncology and the National Comprehensive Cancer Network. Identifying an effective intervention to improve survivors’ knowledge about and self-efficacy in managing surveillance, and improve their receipt of surveillance, will lead to improved clinical outcomes for the large and growing population of CRC survivors.

PI_NAMEs: HAWLEY, SARAH T;VEENSTRA, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult Children;American Society of Clinical Oncology;arm;base;Black race;Blood Tests;Cancer Center;Cancer Intervention;cancer recurrence;Cancer Research Network;cancer risk;Cancer Survivor;Cancer Survivorship;cancer survivorship care;Caring;Clinical;cohort;Colorectal Cancer;Communication;Community Clinical Oncology Program;Confusion;Consensus;Consolidated Framework for Implementation Research;Disparity;Early Diagnosis;Education;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Endoscopy;Enrollment;Ensure;Equity;Family member;Friends;Future;Guidelines;Image;improved;improved outcome;innovation;Intervention;Interview;Knowledge;Malignant Neoplasms;Medical Records;Minority;National Comprehensive Cancer Network;oncology program;Outcome;Participant;Patients;Perception;Persons;pilot test;Population;population based;Positioning Attribute;practice setting;preference;Process;process evaluation;programs;prototype;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Resources;satisfaction;Self Efficacy;Series;Southwest Oncology Group;Spouses;Survivors;survivorship;Time;Training;Translating;United States;usability;web site

PROJECT_TITLE: A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention to Promote Guideline-Concordant Colorectal Cancer Surveillance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Narrative DNA-protein cross-links at 3′-DNA termini arising from apurinic/apyrimidinic sites that are induced by various endogenous and exogenous genotoxins, if not repaired, can have toxic effects and may lead to cell death. TREX1, the major human 3′ to 5′ exonuclease, has an unexpected role in processing DNA lesions at 3′-termini. We propose to study the formation and repair mechanisms of these DNA-protein cross-links, and investigate the functions and regulatory mechanisms of TREX1 in DNA repair.

PI_NAMEs: YANG, KUN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Aging;Antineoplastic Agents;Biochemistry;Biological Markers;Cell Death;Cells;Cellular biology;chemical synthesis;chemotherapy;cytotoxic;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Methylation;DNA Repair;DNA-protein crosslink;Enzymes;Exonuclease;Genetic Transcription;Genomic Instability;Goals;Human;In Vitro;Knowledge;Left;Mass Spectrum Analysis;Molecular Biology;Mutagens;novel;novel therapeutic intervention;nuclease;Organic Synthesis;Oxidative Stress;Phosphodiesterase I;prevent;programs;protein crosslink;Proteomics;recruit;repaired;Reporting;Research;response;Role;Single Strand Break Repair;Site;synergism;Techniques;therapeutic target;Three Prime Repair Exonuclease 1;Toxic effect;Trypsin;Work

PROJECT_TITLE: Formation and Repair Mechanisms of DNA-Protein Cross-Links, and Functions and Regulatory Mechanisms of TREX1 in DNA Repair


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_DEPT: DERMATOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Transposable elements constitute a significant part of the non-coding genome, while their inappropriate activation has been implicated in pathogenesis of over 120 human diseases including autoimmune disorders. In this application, we will address the following questions: 1) Are there any differences in the expression of genome transposable elements between epidermal keratinocytes isolated from the skin of African American, Hispanic and Asian origin and non-Hispanic White origin, 2) Which mechanisms regulate transposable element silencing in keratinocytes of different ethnic groups, and 3) Whether modulation of inflammatory response by nucleoside reverse transcriptase inhibitors might serve as new approach for management of skin inflammatory conditions in individuals with understudied skin types. The generated outputs on this project will provide a platform for translation of these results into clinics and will promote the development of novel therapeutic interventions, which hopefully could serve as new paradigm for management of skin inflammatory conditions in patients with skin of color and their prevention.

PI_NAMEs: BOTCHKAREV, VLADIMIR A (contact);LAU, NELSON C;SHAROV, ANDREY

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Acne;Address;Administrative Supplement;Affect;African American;African American population;Aftercare;Anti-viral Response;Antigen Presentation;Appearance;Area;Asian;Atopic Dermatitis;Autoimmune Diseases;Automobile Driving;Biology;CCL20 gene;Censuses;chemokine;Child;Chromatin;Clinic;Clinical;Code;Collaborations;comparative;Complex;Cytoplasm;Data;Data Correlations;demographics;Dermatology;Development;Disease;DNA;DNA Methylation;DNA Transposable Elements;Double-Stranded RNA;ds-DNA;Elements;Endogenous Retroviruses;Enhancers;Epidermis;Epigenetic Process;ethnic disparity;Ethnic Origin;Ethnic Population;Family;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genomic Instability;Genomics;Grant;Hidradenitis Suppurativa;Hispanic;Histamine;histone modification;HIV;Hospitalization;Human;human disease;Human Genome;IL17 gene;IL7R gene;Immune response;Immunoglobulin Genes;improved;in vitro Model;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;inhibitor;insight;Interferons;Interleukin Receptor;keratinocyte;Laboratories;Life;Lupus Erythematosus;Maintenance;Malignant Neoplasms;Maps;Mediating;Modeling;Modernization;Molecular;mortality;mouse genome;NF-kappa B;Not Hispanic or Latino;novel;novel strategies;novel therapeutic intervention;Nuclear;Nucleic Acid Regulatory Sequences;Nucleosides;Outcome;Output;Pathogenesis;Pathway interactions;patient population;Patients;Pattern;Persons;pharmacologic;Pharmacology;Population;POU2F1 gene;Prevention;Production;Proteins;Psoriasis;Publishing;RANTES;Recombinants;Regulation;RELA Pathway;Repetitive Sequence;Reporting;Research;Resistance;response;Retrotransposon;Reverse Transcriptase Inhibitors;senescence;Signal Pathway;Signal Transduction;Skin;Skin Aging;skin barrier;skin color;skin disorder;skin organogenesis;Testing;three dimensional cell culture;transcription factor;Transcriptional Silencer Elements;transcriptome;Translations;Untranslated RNA;UV Radiation Exposure;Viral;viral RNA

PROJECT_TITLE: Genome transposable elements as drivers of inflammation in understudied skin types

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE R-loops, considered by-products of transcription, are important epigenetic regulators of gene expression and contribute to fundamental biological processes in various organisms. The proposed studies will investigate the functions of R-loops and the R-loop-dependent factors that regulate gene transcription, epigenetic modification, and DNA damage repair. A successful completion of these studies will elucidate novel mechanisms of regulatory R-loops in the context of pluripotency, early development, and tissue homeostasis.

PI_NAMEs: HUANG, XIN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Acceleration;B-Cell Activation;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;Biological Process;Bone Marrow;CDX2 gene;Complex;conditional knockout;demethylation;Development;developmental plasticity;Disease;DNA;DNA Damage;DNA Repair;Embryo;Endoderm;Epigenetic Process;GATA4 gene;Gene Activation;Gene Expression;Genetic Transcription;genome integrity;Genome Stability;genome-wide;genomic locus;Goals;Histones;Homeostasis;homologous recombination;Human;Human Development;human disease;human embryonic stem cell;Hybrids;IgG1;Immunization;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Malignant - descriptor;Mediating;Mitosis;Modification;mouse model;Mus;novel;nucleic acid structure;Occupations;Organism;Pathway interactions;Physiological Processes;pluripotency;Polycomb;programs;recruit;Regulator Genes;Repression;Research;Resolution;Risk Factors;RNA;Single-Stranded DNA;Spleen;Structure of germinal center of lymph node;System;Tissues;transcription factor;unpublished works

PROJECT_TITLE: The Regulatory R-loops in Pluripotency, Early Development, and Tissue Homeostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Mental Health;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Autologous and allogeneic hematopoietic stem cell transplant (HCT) survivors experience a substantial and drastic deterioration in their sexual function, which persists for many years following their transplant. Despite the prevalence of sexual dysfunction in HCT survivors, interventions to address the multidimensional sexual health concerns of HCT survivors are lacking. This proposal seeks to assess the efficacy of a patient-centered, evidence-based, self-administered, digital app (SHIFT) for improving sexual health outcomes, quality of life, and psychological distress in HCT survivors.

PI_NAMEs: EL-JAWAHRI, AREEJ  (contact)

PROGRAM_OFFICER_NAME: BUSCETTA, ASHLEY JIN

PROJECT_TERMS: Address;Allogenic;Anxiety;anxiety symptoms;Attention;Autologous;Biological;Biological Factors;cancer transplantation;chronic graft versus host disease;Cicatrix;Clinical;Communication;Complication;curative treatments;Data;depressive symptoms;Deterioration;digital applications;digital health;digital intervention;digital treatment;Dimensions;efficacy evaluation;efficacy testing;empowerment;Enrollment;Ensure;Environment;evidence base;experience;Fatigue;Female;Fright;Functional disorder;General Hospitals;Genitalia;Goals;Hematology;Hematopoietic Stem Cell Transplantation;Home;Hormonal;Image;Impairment;improved;improved outcome;Infrastructure;innovation;interest;Intervention;intervention effect;intimate behavior;Late Effects;male;Massachusetts;Mediating;Mediator;Medical;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;multi-site trial;multimodality;Nature;novel;Outcome;Pain;patient oriented;Patient Outcomes Assessments;patient population;Patients;Persons;Play;Population;Prevalence;Privacy;Process;psychological distress;Psychological Factors;psychological outcomes;Quality of Care;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Priority;Role;satisfaction;Self Administration;Sex Functioning;Sexual Dysfunction;Sexual Health;Site;Sleeplessness;social factors;social norm;Substance abuse problem;Supportive care;Survivors;Symptom Burden;Testing;therapy development;transplant centers;transplant survivor;Transplantation;treatment as usual;treatment strategy;trial comparing;United States;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Title: Multi-Site Randomized Controlled Trial of a Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative: We propose the development of a new automated frailty and fitness scoring system, the Pittsburgh Transplant Fitness Score (PTFS), for predicting lung transplant outcomes. The PTFS will be designed to provide an objective, reliable, and efficient assessment of a patient's fitness for lung transplant using pre-transplant data, enabling accurate predictions of intra-operative and post-operative transplant outcomes.

PI_NAMEs: HAGE, CHADI ANTONIOS;PU, JIANTAO  (contact);SANCHEZ, PABLO G

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Accounting;Address;Adipose tissue;Age;Algorithms;Anatomy;Arteries;artificial intelligence algorithm;artificial intelligence model;automated algorithm;Awareness;Biological;bone;candidate selection;Cardiac Volume;Caring;Categories;Characteristics;Chest;chest computed tomography;Classification;Clinical;Computer Models;Computers;Data;demographics;design;Development;effective therapy;Elements;Evaluation;Event;expectation;fitness;frailty;Gender;Geometry;Goals;graft dysfunction;Hand Strength;Health;Image;image processing;improved;Individual;Intensive Care Units;Intraoperative Complications;Life;Lung;Lung Diseases;Lung Transplantation;lung volume;Machine Learning;Mechanics;medical specialties;Methods;model development;Modeling;Morphology;novel;Operative Surgical Procedures;Organ Donor;Organ Transplantation;Outcome;outcome prediction;patient population;Patient Self-Report;Patients;Performance;Phenotype;Physical Performance;Population;post-transplant;Postoperative Complications;Postoperative Period;potential biomarker;primary outcome;Procedures;Pulmonary function tests;Race;Retrospective cohort;Scanning;Series;Shapes;Skeletal Muscle;Solid;Sternum;subcutaneous;System;Techniques;Test Result;Testing;Thoracic cavity structure;Time;Tissues;tool;Transplant Recipients;Transplantation;treatment guidelines;United States;Veins;Visceral;Visualization;Waiting Lists;Walking;Weight;X-Ray Computed Tomography

PROJECT_TITLE: An Automated Frailty Scoring System for Lung Transplantation Based on Bio-Geo-Composition

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Therapeutics formulated through nanotechnology approaches (Nanotherapeutics) are at the forefront of clinical translation for treating a variety of diseases. In this project, we will interrogate the fundamental mechanisms of how myeloid cell – a critical mediator of inflammation, interact with nanotherapeutics and direct their targeting to inflammation. The results of this study will enable the rationale design and of inflammation-targeting nanotherapeutics for clinical translation.

PI_NAMEs: ZHANG, FAN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TITLE: Reveal myeloid cell-mediated targeting through nano-bio interface

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Ligand gated ion channels are proteins that enable our cells to fine-tune their intracellular environments based on chemical cues, and the dysregulation of these proteins is a major driver of human disease. The details of how ligand gated ion channels function are critical to understand for therapeutic design, yet despite their importance, the mechanisms of function are unclear. We are elucidating the molecular mechanisms of how ligand gated ion channels function to understand how they regulate our cells in health and provide foundations for disease treatment.

PI_NAMEs: TWOMEY, EDWARD C (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;AMPA Receptors;Biophysics;Cell Communication;Cells;chemical binding;Chemicals;Communication;Cryoelectron Microscopy;Cues;design;Disease;Electrophysiology (science);Environment;Extracellular Domain;Foundations;Health;human disease;Intracellular Space;Ion Channel;Ion Channel Gating;Ion Channel Protein;Ions;Knowledge;Ligands;Mediating;millisecond;Molecular;Nervous System Disorder;Neurons;Physiological;Protein Subunits;Proteins;Reaction;receptor function;Regulation;Research;Resolution;Role;Technology;Therapeutic;Time

PROJECT_TITLE: Ligand Gated Ion Channels Across Time and Space


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Arthritis;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Osteoarthritis;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: The proposed research is relevant to public health because the newly gained knowledge of sex- specific AD progression may lead to development of personalized medicine to target patients in a sex and gender specific manner for precision medical treatment. Thus, the proposed research is relevant to the part of NIH’s mission that translating scientific discovery into health that will help to reduce the burdens of human disability.

PI_NAMEs: CHEN, QIAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: AD transgenic mice;Administrative Supplement;Aging;aging mechanism;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Astrocytes;Award;brain tissue;Cartilage;Cell Aging;Cell Lineage;Cells;clinical practice;Degenerative Disorder;Degenerative polyarthritis;Dementia;derepression;Development;disability;Disease Progression;DNA Transposable Elements;early onset;Female;Gender;Goals;Grant;Health;High Prevalence;Human;human female;Human Genome;Inflammation;Injury;innovation;joint destruction;Joints;Knowledge;male;Medical;Methodology;Mission;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neurons;Parents;Pathogenesis;Pathologic;Patients;Pattern;personalized medicine;Pilot Projects;Predisposition;Prevention;Prevention strategy;Process;Public Health;Research;response;Retrotransposon;sex;Sex Differences;sexual dimorphism;skeletal;Testing;transcriptome sequencing;Translating;treatment strategy;United States National Institutes of Health;Women's prevalence;Work

PROJECT_TITLE: Single-Cell Transposon Activation in the CNS during AD Progression: Sex-dependent Mechanisms

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The ability to construct complex molecules is crucial to the development of modern medicines. As traditional paradigms of molecular complexity, natural products have long served to fuel the development of modern organic synthesis and as rich sources of therapeutic agents. This proposal seeks to expand access to molecular complexity through two distinct approaches to such compounds: leveraging readily available aromatic building blocks to access highly oxygenated anticancer terpenes via novel dearomatization strategies, and breaking symmetry within simple symmetrical starting materials en route to complex bioactive alkaloids.

PI_NAMEs: SMITH, MYLES WARWICK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Expanding Access to Molecular Complexity through Natural Product Synthesis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Project Narrative Since the 1950’s we have known about the existence of ‘jumping genes’ – transposable elements that selfishly increase in copy number within host genomes. However only recently did we come to understand that the host has a defense system based on small RNAs for combating unchecked proliferation of these genomic parasites. To date we know very little about how this defense system evolves within and between populations to combat new and active transposable elements, or about the actual mechanisms of transposable element suppression by this system. This proposal aims to address this shortfall by developing a comparative genomics approach to the small RNA defense system, both within populations and between species. This will yield new insights into the genomic conflict of transposable elements and their hosts and variability in host susceptibility to transposable elements.

PI_NAMEs: SIGNOR, SARAH  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Alternative Splicing;Biology;combat;comparative genomics;Complex;Conflict (Psychology);Developmental Biology;DNA Transposable Elements;Drosophila genus;Drosophila melanogaster;epigenetic silencing;Eukaryota;Evolution;experimental study;Fertility;fitness;Genetic Recombination;Genetic Transcription;Genome;Genome Stability;Genomic approach;Genomics;Genotype;Germ Cells;Germ Lines;Health;Heterochromatin;Host Defense;Human;Individual;insight;Invaded;Jumping Genes;Organism;Parasites;piRNA;Population;Population Genetics;Post-Transcriptional Regulation;Predisposition;Production;Proliferating;Research;Small RNA;Somatic Cell;System;Transcript;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: Co-evolutionary dynamics between transposable elements and their hosts


ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE – OVERALL This Core grant provides shared facilities for an energetic and productive cohort of scientists at the University of California Davis who seek to understand structure and function of the visual system in health and disease. It provides an environment that facilitates collaboration across vision science disciplines and clinical vision science.

PI_NAMEs: USREY, W MARTIN (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animals;Applications Grants;California;Clinical;cohort;Collaborations;Collection;college;Communities;Core Facility;Core Grant;cost;cost efficient;Custom;Data;Discipline;Disease;Eligibility Determination;Environment;Faculty;Fostering;Foundations;Funding;Goals;Grant;Growth;Health;Home;Human Resources;Individual;innovation;Institution;interdisciplinary approach;Laboratories;Microscopy;Molecular;multidisciplinary;ocular imaging;Play;Postdoctoral Fellow;Principal Investigator;Productivity;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Scientist;Services;skills;Software Engineering;Structure;student training;Talents;Technical Expertise;tissue processing;tool;Training Programs;Translational Research;Universities;Vision;Vision research;vision science;Visual System;Work

PROJECT_TITLE: VISION RESEARCH CORE GRANT


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: OAKES, LISA M (contact)

PROJECT_TERMS: Applications Grants;career;Collaborations;Communities;Complex;Computer software;Computers;Core Grant;cost;cost effective;Creativeness;Custom;Data;data acquisition;Data Analyses;data sharing;data streams;Equipment;experimental study;Faculty;Funding;Future;Goals;Individual;Laboratories;multidisciplinary;novel;Productivity;recruit;Research;Research Personnel;Scientist;Services;Software Design;software development;Software Engineering;Stimulus;Time;Vision;Vision research;vision science

PROJECT_TITLE: Software Engineering Core


PI_NAMEs: BURNS, MARIE E (contact)

PROJECT_TERMS: adeno-associated viral vector;Cells;Cellular biology;Cloning;Collaborations;Communities;Consultations;Core Facility;Core Grant;cost;cost effective;Creativeness;Data;design;design and construction;Faculty;Fertilization;flexibility;Funding;Future;Genes;Goals;Individual;Knowledge;Laboratories;laboratory experience;Laboratory Personnel;Lentivirus Vector;Methods;Molecular;Molecular Biology;multidisciplinary;Plasmid Cloning Vector;Plasmids;Production;Productivity;Reagent;recruit;repository;Research;Research Personnel;Services;Supporting Cell;targeted delivery;Training;vector;Viral;Viral Packaging;Viral Vector;Vision research;vision science

PROJECT_TITLE: Molecular Construct and Packaging Core


PI_NAMEs: GLASER, THOMAS M. (contact)

PROJECT_TERMS: Animals;Biological;Cells;Collaborations;Communication;Communities;Core Grant;cost;cost effective;Creativeness;cryostat;Data;Dedications;Devices;Electron Microscopy;Equipment;Faculty;Freeze Substitution;Funding;Future;Goals;graduate student;Hazardous Waste;Heavy Metals;Image;Individual;Knowledge;laboratory experience;Laboratory Personnel;light microscopy;Microscopy;Plant Resins;polymerization;Polymers;Postdoctoral Fellow;Process;Productivity;Reagent;recruit;Refrigeration;Research;Research Personnel;Resources;Salts;Services;Solvents;Specimen;Stains;System;tissue processing;Tissues;Training;ventilation;Vision research;vision science

PROJECT_TITLE: Microscopy and Tissue Processing Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: ZAWADZKI, ROBERT J (contact)

PROJECT_TERMS: adaptive optics;adaptive optics scanning laser ophthalmoscopy;Angiography;Animals;Anterior;Cell Physiology;Cells;Cellular Structures;Collaborations;Communication;Communities;Consultations;Core Grant;cost;cost effective;Creativeness;Data;Data Set;Disease;Equipment;Experimental Designs;Faculty;Fluorescence;Fluorescence Angiography;Funding;Fundus;Fundus photography;Future;genetic manipulation;Goals;Image;Image Analysis;Imaging Device;Imaging technology;in vivo;Individual;instrumentation;laboratory experience;Laboratory Personnel;Lasers;Longitudinal Studies;Mus;ocular imaging;Ophthalmoscopy;Optical Coherence Tomography;Phase;Procedures;Productivity;recruit;Research;Research Design;Research Personnel;Resolution;Resources;Retina;retinal neuron;Rodent Model;Scanning;Services;Structure;Structure of retinal pigment epithelium;Technology;Time;Vision research;vision science

PROJECT_TITLE: Small Animal Ocular Imaging Core


NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: THOMASY, SARA MICHELLE (contact)

PROJECT_TERMS: Accreditation;Animal Experimentation;Animal Model;Animals;Applications Grants;career;Collaborations;Communication;Communities;Core Grant;cost;Creativeness;Data;digital;Electroretinography;Equipment;Faculty;Funding;Fundus photography;Future;Goals;Image;imaging system;in vivo;Individual;innovation;instrumentation;Interdisciplinary Study;Laboratories;Microsurgery;nonhuman primate;ocular imaging;Operative Surgical Procedures;Oryctolagus cuniculus;Procedures;Process;Productivity;Rattus;recruit;Research;Research Design;Research Personnel;Resources;Scientist;Services;Technology;Therapeutic;Vision;Vision research;vision science

PROJECT_TITLE: Large Animal Core


ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: This P30 Center Core Grant for Vision Research provides critically important resources that support the overall research program at the Massachusetts Eye and Ear Infirmary, and in particular supports the translation of new knowledge into clinical information that positively impacts the diagnosis and care of patients affected by blinding visual disorders.

PI_NAMEs: WIGGS, JANEY L (contact)

PROJECT_TERMS: Affect;Award;base;Basic Science;biobank;Bioinformatics;Biological;career development;Center Core Grants;Clinical;Clinical Data;clinical translation;clinically relevant;Collaborations;Core Facility;Core Grant;Data;Development;Diagnosis;Diagnostic;Discipline;Disease;Ear;Equity;Event;Eye;Eye diseases;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Gene Expression Profiling;Genetic;genetic association;genome resource;genomic data;Genomics;Goals;Grant;Growth;Individual;Institution;International;Knowledge;Laboratories;Link;Massachusetts;Measures;medical schools;Methods;Modality;Molecular;next generation sequence data;novel;Ophthalmology;Outcome;Patient Care;Patients;precision medicine;Process;Productivity;programs;Publications;Research;Research Personnel;Resources;Risk Factors;Sampling;Scientist;Statistical Data Interpretation;statistics;Therapeutic;Translations;Vision;Vision Disorders;Vision research

PROJECT_TITLE: P30 Core Grant for Vision Research


PROJECT_TERMS: Advisory Committees;Budgets;Center Core Grants;Core Grant;Ear;Ensure;Equity;Eye;Goals;Massachusetts;Resources;Services;Vision research

PROJECT_TITLE: P-30 Admin Core


PROJECT_TITLE: Biobank Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome

PI_NAMEs: SEGRE, AYELLET VERED (contact)

PROJECT_TERMS: Basic Science;Bioinformatics;Biostatistics Core;career;career development;Clinical;Clinical Investigator;Collaborations;Communities;Computer software;Core Grant;Data;Data Analyses;Disease;Ensure;Equity;exome sequencing;Genes;Genetic;genome sequencing;genome wide association study;genomic data;Genomics;Goals;Human Resources;improved;Investigation;Laboratory Study;Methods;Modality;next generation sequence data;next generation sequencing;novel diagnostics;novel therapeutics;Other Genetics;Pathogenicity;polygenic risk score;Productivity;programs;Qualifying;Research;Research Personnel;Research Project Grants;research study;Resource Allocation;Resources;response;Scientist;statistics;transcriptome sequencing;translational impact;Translational Research;Vision;Vision research;vision science;whole genome

PROJECT_TITLE: Bioinformatics Biostatistics Core


PI_NAMEs: PIERCE, ERIC A (contact)

PROJECT_TERMS: career;career development;Collaborations;Copy Number Polymorphism;Core Grant;Data;data acquisition;Dideoxy Chain Termination DNA Sequencing;Discipline;Ear;Ensure;Equity;exome sequencing;Exons;experience;experimental study;Eye;Eye diseases;Genes;Genetic;genome resource;genome sequencing;genomic data;Genomics;Genotype;Goals;Human Resources;improved;Inherited;Investigation;Methods;next generation sequencing;Productivity;programs;Research;Research Personnel;Resource Allocation;Resources;Role;Scientist;Services;Site;Technology;Testing;timeline;transcriptome sequencing;Translational Research;Vision;Vision research;vision science;whole genome

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: This project focuses on prion-based behaviors of components within the chromatin remodeling complexes - SWI/SNF (SWItch/Sucrose Non-Fermentable) in yeast and BAF (BRG1- or BRM-Associated Factor complex) in humans. The research will provide mechanistic insights into prion-conferred transcriptomic modifications and phenotypes. It will also characterize prion-like activities of BAF proteins and their mutants linked to cancers and neurological diseases.

PI_NAMEs: DU, ZHIQIANG  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Adopted;Algorithms;alpha synuclein;Amyloid beta-Protein;amyloid structure;Architecture;Area;ATP phosphohydrolase;base;Behavior;beta pleated sheet;Biochemical;Biological;Biological Assay;Biological Process;Biology;cancer type;Cell Physiology;Cells;Cellular Assay;cellular pathology;Centrifugation;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Coin;Complex;Computational Biology;Computer Analysis;Data;Disease;Ensure;Environment;Etiology;Exhibits;experimental study;Genetic;Genetic Transcription;Goals;Health;Human;Human Cell Line;human disease;Human Pathology;In Vitro;insight;Length;Link;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;member;Modeling;Modification;Molecular Conformation;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;novel therapeutic intervention;Organism;Orthologous Gene;Outcome;Pathogenicity;Phenotype;Play;prion-based;prion-like;Prions;protein aggregation;protein complex;Proteins;Proteomics;proteostasis;PrP;Recombinants;Reporter;Research;Role;SMARCA4 gene;Structure;success;Sucrose;System;tau Proteins;Techniques;Testing;TP53 gene;Transcriptional Regulation;transcriptome sequencing;transcriptomics;tumor;tumorigenesis;Variant;yeast prion;Yeasts

PROJECT_TITLE: Understanding prion-mediated transcriptional modifications and cellular phenotypes: insights into the role of Swi1 prion and prion-like behaviors of BAF proteins

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

PHR: PROJECT NARRATIVE Adverse childhood experiences (ACEs) are cumulative childhood exposures to potentially traumatic family and community experiences that can have lasting, negative impact on health, with potential intergenerational transmission of effects. The purpose of this mixed methods study is to understand how parents' exposures to ACEs and positive childhood experiences (PCEs) impact their parenting practices, particularly in the context of living in unsafe neighborhoods. This study will advance the science of ACEs by elucidating protective and health-promoting factors in the intergenerational transmission of ACEs and explore a method of understanding how neighborhoods influence the impact of ACEs and PCEs on parenting practices using community-level geospatial data.

PI_NAMEs: HOPPE, EMILY  (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: 8 year old;Address;Adult;adverse childhood events;Affect;arm;Baltimore;Behavioral;Buffers;Cessation of life;Characteristics;Child;Child Rearing;Child Welfare;Childhood;Cities;Clinical;Communities;community violence;contextual factors;Cross-Sectional Studies;Data;deprivation;design;Dimensions;Emotional;Environment;experience;Exposure to;Family;Family member;Feeling;Goals;Health;health disparity;Health Promotion;Home;Imprisonment;improved;Individual;innovation;intergenerational;Intervention;Interview;Investigation;Low income;Mental Health;Methods;Modeling;multilevel analysis;neglect;neighborhood safety;Neighborhoods;neurobehavioral;Outcome;Parents;Participant;Perception;Persons;Phase;phenomenological models;physical conditioning;Policies;Poverty;prevent;Process;protective effect;protective factors;Psychopathology;psychosocial;Reaction;Recurrence;Reporting;Research;resilience;Resources;response;Role;Safety;Sampling;Schools;Science;social;Source;Strategic Planning;Surveys;Testing;transmission process;Urban Community;urban setting;Violence;violent crime;working group

PROJECT_TITLE: Parents' Adverse and Positive Childhood Experiences and their Parenting Practices in the Context of Neighborhood Safety


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Peripheral immune aberrancies are recently reported in individuals with AD; however, the immune mechanisms connected to the onset and progression of neurological disease is unknown. In this proposal, we describe a comprehensive, ‘systems biology’ approach to determine AD-linked immune signatures in both the peripheral blood and brain to gain new insight into the precise immune drivers that cause neuroinflammation and cognitive decline.

PI_NAMEs: SNYDER-CAPPIONE, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Addendum;Address;Age related comorbidities;age stratification;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Automobile Driving;Award;biobank;Bioinformatics;Biopsy;Blood - brain barrier anatomy;Blood Circulation;Blood specimen;Boston;Brain;Brain Pathology;brain tissue;Cells;Circulation;Classification;cognitive change;Cognitive deficits;cohort;Color;combat;Cytometry;Data;Data Analyses;data platform;Data Set;Dementia;Deposition;detection assay;Diagnostic;Disease;Disease Progression;dysbiosis;early detection biomarkers;Elderly;Enzyme-Linked Immunosorbent Assay;Event;Flow Cytometry;Funding;Gastrointestinal tract structure;Glean;Health;Heterogeneity;HIV;HIV Infections;Image;Immune;Impaired cognition;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;insight;intestinal barrier;Intestinal permeability;Leaky Gut;Link;Longitudinal cohort;Manuscripts;Measurement;Measures;microbiota;Microglia;mild cognitive impairment;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurons;normal aging;novel;novel marker;Onset of illness;outreach program;Parents;Participant;Pathogenesis;Pathogenicity;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Permeability;Phenotype;Plasma;Population;Preparation;prevent;Proteins;Publications;Reporting;Research;Role;Sampling;Sampling Studies;Stromal Cells;systemic inflammatory response;Systems Biology;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;therapeutic target;Tissue Sample;United States National Institutes of Health;Universities;Visualization;Work;γδ T cells

PROJECT_TITLE: Gamma delta T cells promote inflammation in aviremic HIV infection and normal aging

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Many intensive care unit survivors suffer from pervasive cognitive impairment comparable to patients with early-stage Alzheimer’s disease. While the causative mechanisms that lead to abrupt cognitive impairment are unclear, recent studies show that lung vascular endothelium produces cytotoxins after nosocomial bacterial infection. This application seeks to examine the effects of lung infection and sepsis using a novel, humanized amyloid-β mouse model to increase the translational relevance of studies described in the parent award.

PI_NAMEs: LIN, MIKE T (contact)

PROJECT_TERMS: Acute Lung Injury;Address;Administrative Supplement;Age;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Anesthetics;Animal Behavior;Animal Testing;Animals;antimicrobial;Award;Bacteria;Bacterial Infections;Bacterial Pneumonia;behavioral study;Blood;Blood Circulation;Blood Vessels;Brain;Brain Hypoxia;Brain Injuries;brain parenchyma;Bronchoalveolar Lavage Fluid;Cell Physiology;Cells;Cerebral Ventricles;Cerebrospinal Fluid;cerebrovascular;Characteristics;Chemosensitization;Circulation;Clinical;cognitive function;cognitive testing;Contracts;coronavirus pandemic;Critical Care;Critical Illness;Cultured Cells;cytotoxic;cytotoxicity;Cytotoxin;Data;Dendritic Spines;density;Deposition;design;disease transmission;Endothelial Cells;Endothelium;experimental study;Exposure to;follow-up;Functional disorder;Funding;Gender;Generations;Health;high risk;hippocampal pyramidal neuron;Hospitals;Hour;Human;Impaired cognition;Impairment;In Vitro;in vivo;Infection;Injury;insight;Intensive Care Units;Journals;Learning;Long-Term Potentiation;Lung;Lung infections;Mediating;Microtubules;Molecular Weight;mouse model;Multi-site clinical study;Mus;neural;Neurocognitive;Neurologic;Neurons;neurotoxic;neurotropic;Nosocomial pneumonia;novel;novel therapeutic intervention;Organ;parent grant;parent project;pathogen;Pathologic;Patients;Phosphorylation;Plasma;Pneumonia;Preparation;prevent;prion-like;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;repaired;Reporting;response;sedative;Sepsis;Slice;Stains;Survivors;Synapses;Tail;tau aggregation;tau Proteins;Testing;Vascular Endothelium;Veins;Viral;Viral Physiology;Viral Pneumonia;web site;Whole Blood;Work

PROJECT_TITLE: Nosocomial pneumonias impair cognitive function

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Cerebral blood flow (CBF) measures cerebrovascular health and regional brain function and has broad range of applications in both neuroscience and clinical care. In this Academic Industrial Partnership, neuroimaging investigators from the University of Pennsylvania and the University of Maryland partner with investigators from Siemens Medical Solutions, USA to develop and disseminate a robust MRI technology that can noninvasively quantify CBF. This supplemental project specifically focuses on optimizing CBF measurements for use in Alzheimer's disease and related disorders research.

PI_NAMEs: DETRE, JOHN A (contact);WANG, ZE

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Academia;Administrative Supplement;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;arterial spin labeling;Biological;Biological Markers;Biomedical Research;Blood;Blood flow;blood flow measurement;Blood Vessels;Brain;brain health;Brain region;brain tissue;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;Cerebrovascular Insufficiency;Clinical;clinical care;Clinical Research;Code;Cognitive;cohort;Collaborations;Computer software;Data;data acquisition;Deceleration;Dedications;Development;diagnostic value;flexibility;Functional disorder;Future;Grant;hypoperfusion;Image;image reconstruction;Impaired cognition;improved;Industry;industry partner;innovation;Label;Laboratories;Location;Machine Learning;Magnetic Resonance Imaging;Magnetism;Maps;Marketing;Maryland;Measures;Medical;mild cognitive impairment;Morphologic artifacts;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroimaging;Neurosciences;Neurosciences Research;neurovascular coupling;next generation;Noise;older adult;Older Population;parent project;Parents;Participant;Patients;Pattern;Pennsylvania;Perfusion;Philosophy;Physiological;Population;programs;Protocols documentation;Reproducibility;Research;Research Personnel;Resources;response;Scanning;Signal Transduction;Site;specific biomarkers;System;Techniques;Technology;technology development;technology validation;temporal measurement;Testing;Time;Tissues;Tracer;Translating;United States National Institutes of Health;Universities;user-friendly;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Visualization;Water;Work

PROJECT_TITLE: Academic Industrial Partnership on Advanced Perfusion MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Natural Products;Neurodegenerative;Neurosciences;Patient Safety;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative There is an ongoing substance abuse epidemic in western society. Synthetic psychoactive agents are among the newest, most popular, and least understood of the abused substances. This work focuses on the development of a new platform to understand bath salts and related agents to define novel therapeutic targets to treat toxicity and episodic lethality.

PI_NAMEs: SCHIEFER, ISAAC T (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acute;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;bath salts;Binding;Dementia;Development;Drug Targeting;Drug toxicity;Epidemic;Gene Expression;Hallucinogens;Human;Indoles;interest;Investigation;multiple omics;N,N-Dimethyltryptamine;neuropsychiatric disorder;new therapeutic target;novel;parent project;patient derived induced pluripotent stem cells;Phenethylamines;Phosphotransferases;Psychotropic Drugs;Signal Transduction;Societies;Substance abuse problem;Synapses;Synaptic plasticity;Toxic effect;Work

PROJECT_TITLE: Cross platform analysis of drug targets and toxicity of bath salts

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: Despite its centrality to the human condition, susceptibility to disease, and decades of intense research, there are still many fundamental mysteries surrounding the biological basis of memory. I present a new, reductionist system that will allow rapid progress in our understanding of memory formation and removal. The preliminary findings in Drosophila show extensive molecular and phenomenological similarities to mammalian memory and identify a novel population of neurons that set the threshold for memory formation and control its removal.

PI_NAMEs: CRICKMORE, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TITLE: Molecular and circuit mechanisms of memory prevention and removal

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful skin scars, nodules, abscesses, and sinus tracts in the skin-fold areas that can cause low quality of life. Racial disparities exist in HS; however, contributing factors to these disparities remain unclear. The overall goal of this project is to define the genetic contributors to HS risk using whole-exome sequencing and functional mechanism studies, which may provide new therapeutic targets and treatments for HS patients.

PI_NAMEs: LIAO, WILSON  (contact);MI, QING-SHENG

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Abscess;Affect;African American;Area;biobank;Bioinformatics;Black race;Candidate Disease Gene;Caring;case control;Cellular biology;Chronic;chronic inflammatory disease;Cicatrix;Code;cohort;Data;Dermatologic;Development;Diagnosis;Disease;Disparity;Ethnic Population;exome;exome sequencing;Family;Genetic;genetic resource;Genetic Risk;Genetic study;genetic variant;genome wide association study;Goals;Hidradenitis Suppurativa;Hispanic;Hispanic Populations;Individual;Inflammatory;insight;Knowledge;Latino;Lesion;loss of function;multiple omics;new therapeutic target;Nodule;novel;Pain;Patients;Predisposition;Prevalence;Publishing;Quality of life;Race;racial disparity;racial population;Risk;Severities;Sinus;Skin;Therapeutic;Variant

PROJECT_TITLE: Using whole-exome sequencing to uncover key genetic variants related to Hidradenitis Suppurativa risk in African American and Hispanic population.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE  COPD is the third leading cause of death in the world, and yet roughly half of patients remain undiagnosed. At the same time, a significant proportion of individuals at risk for COPD are undergoing low-dose computed tomography for lung cancer screening. As imaging features such as emphysema can help to identify COPD, the goal of this proposal is to determine how to leverage imaging being performed for lung cancer screening to improve early diagnosis of COPD, which will facilitate earlier risk modification, treatment and reduced disease morbidity and mortality.

PI_NAMEs: HAN, MEILAN K (contact);HATT, CHARLES R

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Adopted;aged;airway obstruction;Assessment tool;Attitude;Belief;Blood Vessels;burden of illness;case finding;Cause of Death;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical practice;clinically significant;cohort;Communication;Communication Tools;computed tomography screening;Data;design;Development;Diagnosis;diagnostic accuracy;Disease;disease diagnosis;disorder risk;Early Diagnosis;Ensure;Evaluation;experience;Future;Goals;Health;health care service utilization;Health Status;Health system;high risk;high risk population;Image;Impaired health;improved;Individual;individual patient;interest;interstitial;Intervention Studies;Interview;Link;low dose computed tomography;Lung;lung cancer screening;lung health;Malignant neoplasm of lung;Methodology;model building;Modeling;Modification;Morbidity - disease rate;mortality;Outcome;Pathogenesis;Pathology;Patient imaging;patient population;Patient risk;Patients;Population;preference;Primary Care Physician;primary care provider;Probability;Process;provider communication;Pulmonary Emphysema;Pulmonary function tests;Pulmonary Hypertension;Pulmonary Pathology;quantitative imaging;radiologist;Recommendation;Reporting;Research;Respiratory Disease;Respiratory Signs and Symptoms;Risk;Scanning;screening;Screening for cancer;Smoking History;Specialist;Spirometry;Standardization;Structure;Symptoms;Testing;Time;tool;United States;United States Centers for Medicare and Medicaid Services;United States Preventative Services Task Force;X-Ray Computed Tomography

PROJECT_TITLE: Leveraging Quantitative Imaging from Lung Cancer Screening to Create Tools to Confront COPD

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Infertility;Prevention;Social Determinants of Health

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: NARRATIVE This project investigates the link between paternal phthalate exposure, seminal plasma metabolomics, and reproductive health outcomes. The study has important public health implications by determining potential pathways by which paternal toxicant exposures influence reproductive health. Seminal plasma metabolomic results will constitute major advances in the fields of environmental and reproductive health by improving clinical assessments of male fertility, and thus, is a critical step toward developing interventions to improve male reproductive health.

PI_NAMEs: PILSNER, J. RICHARD  (contact);SUMNER, SUSAN J

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Affect;androgenic;Biological Markers;Birth Rate;Characteristics;Clinical;Clinical assessments;clinical care;cohort;Cohort Studies;Conceptions;cost effective;Couples;Data;Data Collection;Development;Diagnosis;diagnostic tool;Disease;embryo quality;Embryonic Development;Endocrine Disruptors;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Pollutants;epidemiology study;Epigenetic Process;exposed human population;Female;female reproductive tract;Fertility;Fertilization;General Population;hormone metabolism;Human;improved;Infertility;infertility treatment;innovation;Intervention;Investigation;Link;Lipids;Live Birth;male;male fertility;Male Infertility;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Molecular;novel;novel marker;Outcome;Participant;Pathway interactions;personal care products;phthalates;Pilot Projects;Plastics;Play;Probability;prospective;Public Health;Publishing;Reference Values;Reproductive Health;reproductive outcome;reproductive success;reproductive tract;Research;Resources;Role;sample collection;Sampling;Seminal fluid;Seminal Plasma;small molecule;sperm cell;sperm quality;Spermatogenesis;stem;steroid hormone biosynthesis;subfertility;success;time-to-pregnancy;Toxicant exposure;urinary;Vitamin A;World Health Organization

PROJECT_TITLE: Seminal plasma metabolomic signatures, preconception phthalates and reproductive outcomes.

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE There is a critical need to identify connections between biological factors – not only of neurodegeneration but of vascular, nutritional, and inflammatory systems – underlying ADRD pathology and cognitive outcomes across socioeconomically diverse contexts. We will use cross-national data in the US and India to assess the interplay between context, social factors, and ADRD biology using recently collected cross-nationally harmonized neurodegenerative biomarkers as well as information on cognitive outcomes and other markers of vascular, nutritional, and inflammatory systems. Our results will set the stage to leverage biology to understand social differences in cognition that would not be clear from research in just one country, with the ultimate goal of preventing and/or delaying the onset of ADRD from a global perspective.

PI_NAMEs: CRIMMINS, EILEEN M;GROSS, ALDEN L. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Affect;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-42;Biological;Biological Factors;Biological Markers;Biological Process;Biology;Blood Vessels;Characteristics;Classification;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Country;Data;Data Collection;data harmonization;Data Set;Dementia;dementia burden;dementia risk;Demographic Factors;Derivation procedure;design;Development;Differential Diagnosis;Disease;Disease Marker;drug development;Drug Targeting;Economic Factors;Economics;Equity;Evaluation;follow-up;Funding;Glial Fibrillary Acidic Protein;Goals;Impaired cognition;India;Inequity;Inflammatory;innovation;Intervention;Light;low and middle-income countries;low socioeconomic status;Magnetic Resonance Imaging;Malnutrition;member;minimally invasive;modifiable risk;Modification;Nerve Degeneration;neurofilament;neuropathology;novel;novel strategies;Nutritional;Older Population;Outcome;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Pattern;Persons;Plasma;Play;Population;Prevalence;prevent;Prevention strategy;protective factors;Protocols documentation;rate of change;Research;Respondent;Risk Factors;Sampling;social;Social Behavior;Social Change;social determinants;Social Environment;social factors;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Staging;System;Testing;translational potential;Vascular Diseases;Work

PROJECT_TITLE: Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: Project narrative: The Moffitt Consortium is poised to support the goals of the Blood and Marrow Transplant Clinical Trial Network (BMT CTN) through conduct of important national clinical trials. In addition, we propose a trial testing different chemotherapy regimens given before immunotherapy (CAR-T) for lymphoma patients. The trial aims to determine which chemotherapy approach can improve the likelihood of patients living long term without relapse of lymphoma, and enhance safety of this treatment.

PI_NAMEs: PIDALA, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Address;arm;B-Cell Lymphomas;Biological;Blood;Bone Marrow Transplantation;C-reactive protein;Cancer Center;CAR T cell therapy;CD19 gene;Cell Therapy;Cells;Cellular immunotherapy;chemotherapy;Chemotherapy-Oncologic Procedure;chimeric antigen receptor;chimeric antigen receptor T cells;Cladribine;Clinical;clinical center;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Communities;Consensus;Cyclophosphamide;cytokine;cytokine release syndrome;cytopenia;Data;design;Development;Disease remission;Dose;Enrollment;Environment;Ferritin;fludarabine;Goals;Healthcare Systems;Hematologic Neoplasms;Hematological Disease;Hematopoietic;IL7 gene;Immune;immune effector cell-associated neurotoxicity syndrome;Immunity;Immunotherapy;improved;improved outcome;in vivo;Infection;Inflammation Mediators;inflammatory milieu;Information Dissemination;Infrastructure;Infusion procedures;innovation;Institution;Interleukin-15;Interleukin-6;Knowledge;Leadership;Lymphoma;mathematical model;Minority;Mission;Multicenter Studies;Multicenter Trials;Myeloid-derived suppressor cells;Observational Study;Outcome;Patient-Focused Outcomes;Patients;phase 2 study;phase II trial;phase III trial;primary endpoint;Prior Chemotherapy;Procedures;programs;Progression-Free Survivals;prospective;prospective test;Publications;Randomized;Refractory;Regimen;Regulatory T-Lymphocyte;Relapse;Research;Safety;Science;secondary endpoint;Series;standard of care;Technology;Testing;Time;Toxic effect;Transplantation;Tumor Burden;tumor eradication

PROJECT_TITLE: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) - Core Clinical Centers - UG1

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


NIH_SPENDING_CATS: Biotechnology;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Gene therapy for many blood diseases requires growing blood stem cells in cultures and introducing genes to correct the genetic defects of blood cells. Expanding and modifying blood stem cells in cultured condition is associated with poor quality of proteins which leads to loss of stem cell functions. Our studies will identify and test new small molecular compounds to improve protein quality to preserve blood stem cell function after culture which has the potential to improve the efficiency of gene therapies.

PI_NAMEs: LI, QING  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adopted;Adult;Affect;ATPase Domain;Autoimmunity;Blood;Blood Cells;Blood Preservation;Cells;Chemicals;Clinical;Complex;curative treatments;Cytosol;design;Disease;Dislocations;Endoplasmic Reticulum;Engineering;Ensure;exhaustion;Family;Frequencies;functional decline;functional loss;gene therapy;gene-targeted therapy;Genes;Genetic;Goals;GRP94;Heat-Shock Proteins 90;Hematological Disease;hematopoietic stem cell expansion;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hemoglobinopathies;Hereditary Disease;high throughput screening;Human;immunodeficiency;Impairment;improved;In Vitro;inhibitor;insight;K562 Cells;knock-down;Knock-out;leukemia;Libraries;Maintenance;Mediating;Membrane Proteins;Metabolic;Methods;Molecular;Molecular Chaperones;Mus;Mutation;N-terminal;novel;overexpression;pharmacologic;Phenotype;preservation;Production;Proliferating;Protein Biosynthesis;protein degradation;Proteins;proteostasis;proteostasis loss;Quality Control;reconstitution;Reporter;screening;secretory protein;self-renewal;Sickle Cell Anemia;small molecule;stem cell function;stem cells;System;Testing;Therapeutic;Time;transplant model;Transplantation;Validation

PROJECT_TITLE: Modulation of Endoplasmic Reticulum Associated Degradation to Support Ex Vivo Expansion of Hematopoietic Stem Cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Immunotherapy;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE Membership as a BMT CTN Core Clinical Center is central to the mission of the PENN Medicine (University of Pennsylvania) Cell Therapy and Transplant Program (PENN CTT) to develop and facilitate multidisciplinary, interdepartmental and multi-institutional evaluation of new therapeutic approaches to HCT and CT and to disseminate these findings to health care professionals, the patients and the public to improve the outcome of patients undergoing these lifesaving procedures.

PI_NAMEs: STADTMAUER, EDWARD A (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adult;Advocacy;Age;Allogenic;Area;Autologous;B-Cell Acute Lymphoblastic Leukemia;Blood;Bone Marrow Transplantation;Cancer Center;Caring;Cell Therapy;Cell Transplantation;Cellular immunotherapy;Characteristics;Child;Clinical;clinical center;Clinical Data;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Committee Membership;Communities;Development;Disabled Persons;disadvantaged background;Disease;Disease remission;disorder prevention;Effectiveness;Enrollment;Ensure;Ethnic Origin;Evaluation;Funding Opportunities;Future;Gender;Gene Modified;genetically modified cells;Geography;graft vs host disease;Health Professional;Hematologic Neoplasms;Hematological Disease;Hematologist;Hematology;Hematopoietic Stem Cell Transplantation;Human Resources;Immunobiology;improved outcome;Infusion procedures;innovation;Institution;Lead;Leadership;Life;life span;Link;Malignant - descriptor;Malignant Neoplasms;Measurable;medical schools;Medicine;member;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;Non-Malignant;novel;novel therapeutic intervention;Observational Study;Office of Administrative Management;Oncology;Paper;Patient Care;patient retention;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;phase II trial;Philadelphia;Physician Executives;Pilot Projects;Positioning Attribute;Procedures;programs;Protocols documentation;Publications;Race;Randomized;recruit;repository;Research;Research Personnel;Research Proposals;Residual Neoplasm;Resources;Role;Running;Services;Sex Differences;Site;skills;Socioeconomic Status;Source;Specimen;success;T cell therapy;Transplantation Conditioning;trial enrollment;Umbilical Cord Blood;United States Food and Drug Administration;Universities;University Hospitals;Work

PROJECT_TITLE: BMT CTN Core- University of Pennsylvania Abramson Cancer Center


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Gene mis-regulation is linked to a wide variety of disorders, including developmental defects and cancer. By determining fundamental mechanisms underlying the control of gene expression, this research will increase our understanding of how genes are regulated so that the causes of mis-regulation can be identified in diseased cells. This research will also advance our basic knowledge of quiescence, a cell state implicated in cancer recurrence, with the eventual goal of providing insight into potential targets for drug therapies.

PI_NAMEs: SWYGERT, SARAH GRACE (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Binding;Biochemical;Biochemistry;Biophysics;cancer recurrence;Cell Cycle;Cell Maintenance;Cells;Chromatin;Chromatin Fiber;Chromatin Loop;Chromatin Structure;Code;cohesin;Complex;condensin;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Repair;Fiber;Foundations;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genome;genome-wide;Genomics;Goals;Health;High Mobility Group Proteins;Histone Deacetylation;Human;insight;Knowledge;Link;Malignant Neoplasms;Methods;Microscopy;Modeling;Nucleosomes;Pattern;Physical condensation;Process;programs;promoter;Research;Resolution;Role;Saccharomycetales;single molecule;stem cells;Structure;targeted treatment;Time;Transcriptional Regulation;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanisms and functions of three-dimensional chromatin structures in quiescent cells

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pain Research;Prevention;Primary Health Care

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative This research aims to create a controlled vocabulary for terms defining and classifying dental-care related fear, anxiety, and/or phobia (DFA). We do this by developing the Ontology of Dental care-related Fear, and Anxiety, and/or Phobia (ODFA). The ODFA’s concepts and relations facilitate the development of tools and resources capable of enhancing our understanding of the impacts of DFA, and when applied to study data, the ODFA enables the integration and interoperability of data from multiple studies.

PI_NAMEs: DUNCAN, WILLIAM  (contact);MCNEIL, DANIEL W

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Adolescence;Adult;Agreement;Anxiety;Anxiety Disorders;Appointment;Appointments and Schedules;Behavioral;behavioral and social science;care seeking;Caring;Childhood;Classification;Clinical;Clinical Psychology;Communities;Community Healthcare;Consensus;Controlled Vocabulary;Data;data interoperability;data resource;Data Sources;Dental;Dental Anxiety;Dental Care;Dental caries;Dental Epidemiology;Dentistry;Development;Emergency Situation;Emotional;Endodontics;Etiology;experience;Fright;Functional disorder;Goals;health related quality of life;Health Services Research;Impairment;Individual;interoperability;Intervention;large datasets;lexical;Literature;Maps;Medical;Mouth Diseases;multidisciplinary;Nature;Ontology;ontology development;oral condition;Oral health;Outcome;Pain;Pain management;Patients;Pattern;Periodontal Diseases;Phobias;Population;Prevalence;Preventive;Preventive care;Procedures;Process;psychologic;Pulp Canals;Research;Research Personnel;Resources;response;Scientist;Semantics;societal costs;Societies;stem;Structure;Symptoms;Taxonomy;Terminology;Testing;Thinking;Time;tool development;Tooth Loss;Vocabulary

PROJECT_TITLE: Developing an Ontology for Dental Care-Related Fear and Anxiety:  Toward an Understanding of Problems in Dental Care Utilization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (50)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dietary Supplements;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative The severity of traumatic injuries, as well as complications arising during wound healing, are on the rise, resulting in increased disability and mortality in the US population. The goal of this project is to study the acute imbalance in inflammation that leads to disease progression, and apply this knowledge to engineer nano- and micro-scale biomaterial strategies to resolve chronic inflammation in traumatic and non-healing wounds. These studies will lead to the development of bio-inspired material that can remediate intrinsic and extrinsic inflammatory pathways, resulting in a unifying traumatic injury and wound care strategy for improved patient outcomes.

PI_NAMEs: DUMONT, COURTNEY MARGARET (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Anti-Inflammatory Agents;Biocompatible Materials;Cells;Cessation of life;Chondroitin Sulfates;Chronic;Chronic Disease;chronic wound;cytokine;Cytokine Signaling;Development;disability;Disease Progression;Disparate;Engineering;Equilibrium;experience;Extracellular Matrix;Failure;Glycosaminoglycans;Goals;healing;Immune;Immune response;immunoregulation;Impaired wound healing;Impairment;improved;In Vitro;Inflammation;Inflammatory;injured;Injury;Investigation;Knowledge;Macrophage;Modeling;Molecular;mortality;Mus;nanoengineering;nanoscale;non-healing wounds;Nutrient;Paralysed;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Population;Process;programs;prophylactic;Recovery;recruit;regenerative;remediation;repaired;Resolution;Rodent;Rodent Model;Role;Severities;Site;Skin injury;skin wound;Spinal cord injury;Technology;therapeutic evaluation;therapy outcome;tissue regeneration;tissue repair;Tissues;Traumatic injury;traumatic wound;treatment strategy;wound care;wound healing

PROJECT_TITLE: Glycosaminoglycan-enabled technologies to reprogram chronic inflammatory states

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]