NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Recent studies have found that inflammation in the brain correlates with Alzheimer’s disease progression and may be a major driver of this disease. The studies in this grant application will elucidate the role of a subset of T cells called regulatory T cells in Alzheimer’s disease.

PI_NAMEs: FARRAR, MICHAEL ARCHIBALD (contact);LEE, MICHAEL K

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immune response;Affect;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Applications Grants;Attenuated;Brain;Cell Physiology;Cells;Characteristics;clinically relevant;Comparative Study;Diphtheria Toxin;Disease;Disease Progression;FOXP3 gene;Functional disorder;Future;glial activation;Goals;Human;IL2 gene;IL2RA gene;Immune response;improved outcome;in vivo;Inflammation;Inflammatory;Innate Immune Response;Interferons;Investigation;Kinetics;Knowledge;Label;Location;Microglia;Modeling;mouse model;Mouse Strains;Mus;Nervous System Trauma;neuroinflammation;novel;NRP1 gene;Outcome;Pathogenesis;Pathologic;Play;Population;prevent;Process;Proteomics;Protocols documentation;Regulatory T-Lymphocyte;repaired;Reporter;Role;single-cell RNA sequencing;Symptoms;systemic inflammatory response;T cell response;T cell therapy;T-Cell Depletion;T-cell diversity;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;Tissue Model;Tissues;transcriptomics;Transgenic Mice;Work

PROJECT_TITLE: Regulatory T Cells in Alzheimer's Disease


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Nashville

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Microtubule networks, known as main highways for intracellular transport, organize multiple cellular processes, which often occur simultaneously and in concert with each other. A subset of microtubule-dependent events is needed for an efficient response to cell-cycle or metabolic signaling and thus involve rapid microtubule reorganization. The goals of the Kaverina laboratory are to establish mechanisms whereby initial signals are translated into geometry and biochemistry of microtubule networks and to elucidate how the resulting networks impact cell physiology.

PI_NAMEs: KAVERINA, IRINA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Affect;Affinity;Architecture;Automobile Driving;Behavior;Biochemistry;Biological;Biopolymers;Cell Cycle;Cell Cycle Stage;Cell Physiology;Cells;Cellular biology;Cellular Structures;Collaborations;Complex;Computer Models;crosslink;Cytoskeleton;Event;Funding;Funding Mechanisms;Geometry;Goals;Golgi Apparatus;human disease;Individual;insight;Interphase;Intracellular Space;Intracellular Transport;Laboratories;Laboratory Study;MAPT gene;Metabolic;Methods;Microtubule-Associated Proteins;Microtubule-Organizing Center;Microtubules;Molecular;Molecular Motors;National Institute of General Medical Sciences;novel;Physiological;Positioning Attribute;Process;programs;Publishing;Regulation;Research;Resources;response;Role;Scaffolding Protein;Signal Transduction;Site;Structure;System;Time;trafficking;Translating;Tumor Suppressor Proteins

PROJECT_TITLE: Dynamic architecture and function of microtubule networks

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ALBANY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed project will elucidate the intra- and intergenerational health consequences of life course stress exposure for maternal-infant health in Black U.S. families. This study will identify what stress exposures are most important to intervene with, when in the life course they should be targeted, and how best to do so (e.g., family interventions, community programs, policies). Knowledge gleaned from this research will help to promote maternal-infant health in generations of Black U.S. families.

PI_NAMEs: LIN, BETTY  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Acute;acute stress;Adult;Age;Behavior;behavior observation;Belief;Biological;Birth;Birth Weight;Black American;Black Populations;Black race;black women;Cardiovascular Diseases;Cardiovascular system;Characteristics;Communities;comparison group;Development;developmental plasticity;Discipline of obstetrics;Discrimination;Disease;Disparity;early life stress;Environmental Health;Epidemiologist;Exclusion;experience;Exposure to;Family;Fathers;fetal;Generations;Geographic Information Systems;Gestational Age;Glean;Goals;Gynecologist;Health;Health Promotion;Heterogeneity;Home visitation;Hydrocortisone;Immigration;indexing;Infant;Infant Health;Interdisciplinary Study;intergenerational;Intervention;Knowledge;Life Cycle Stages;Link;Literature;longitudinal, prospective study;Low Birth Weight Infant;Maternal Exposure;Maternal Health;Maternal Mortality;maternal stress;Medical Records;Methodology;Methods;Modeling;Mothers;Nature;Neighborhoods;novel;obstetrical complication;Outcome;Patient Self-Report;Pattern;Physiological;Physiology;Policies;poor health outcome;postnatal;Postpartum Period;Pregnancy;Premature Birth;prenatal;prenatal stress;Process;programs;psychobiologic;Psychologist;Psychophysiology;psychosocial;psychosocial stressors;Race;racial determinant;racial disparity;racial identity;racism;Regulation;Research;resilience;resilience factor;respiratory;Risk;Risk Factors;Role;Salivary;Scientist;Shapes;Sinus Arrhythmia;social;sociodemographics;Stress;stressor;Structural Racism;Suggestion;Testing;Time;Transact;United States;Woman

PROJECT_TITLE: Intra- and Intergenerational Consequences of Maternal Stress Exposure for Maternal-Infant Health in Black U.S. Families

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: GAMM, DAVID M (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;Alleles;Animals;Antibodies;Area;assay development;autosome;Biodistribution;Calcium;Cell Line;Cell Nucleus;Cells;Cellular Assay;Chimeric Proteins;Chinese Hamster;Chloride Channels;CLCA2 gene;Clinical;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Custom;Data;Degenerative Disorder;Development;Development Plans;Disease;Elements;Engineering;Eye;Formulation;Functional disorder;functional restoration;Future;gene editing technology;Genes;genome editing;genome editor;genotoxicity;Goals;Grant;Guide RNA;Hereditary Disease;Human;immunogenicity;improved;in vivo;Individual;induced pluripotent stem cell;Industry;Inherited;Investigational Drugs;Knock-out;Lead;lead candidate;lead optimization;lipid nanoparticle;macula;manufacture;Mediating;meetings;Missense Mutation;Modality;Modeling;Molecular;mutant;Mutation;nanocapsule;next generation sequencing;nonhuman primate;Nonsense-Mediated Decay;novel;Nuclear;nuclease;nucleofection;Optical Coherence Tomography;Organoids;Ovary;patient derived induced pluripotent stem cells;Patients;Penetration;Peptides;Photoreceptors;pre-clinical;pre-Investigational New Drug meeting;Process;programs;prototype;Reporter;Retina;Ribonucleoproteins;RNA Binding;Silicon Dioxide;somatic cell gene editing;stable cell line;Structure of retinal pigment epithelium;subretinal injection;synergism;System;targeted delivery;targeted treatment;technology development;Testing;Therapeutic;therapeutic development;therapeutic genome editing;tool;Toxic effect;trafficking;Validation;Vision;Vitelliform macular dystrophy

PROJECT_TITLE: Develop an engineered Cas effector for in vivo cell-targeted delivery in the eye to treat autosomal dominant BEST disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Acute Respiratory Distress Syndrome (ARDS) is a common, life-threatening condition with no approved drug treatments. Pulmonary edema is a cardinal feature of ARDS and is mirrored closely by edema fluid collected passively in the Heat Moisture Exchanger (HME) filter; thus HME filter edema provides a novel and completely non-invasive window to the alveolar microenvironment. This proposal seeks to understand whether molecular characteristics of HME filter edema predict prolonged respiratory failure and could facilitate enrollment of high-risk patients into ARDS clinical trials.

PI_NAMEs: ROGERS, ANGELA J (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Alveolar;alveolar epithelium;Bilateral;Bioinformatics;Biology;Bronchoscopy;Cessation of life;Characteristics;Classification;Classification Scheme;Clinical;Clinical Research;Clinical Trials;cohort;Collection;Data;Death Rate;Development;Disease;Edema;effective therapy;Electrons;Enrollment;epithelial injury;Epithelium;Failure;Fingerprint;Functional disorder;Future;Goals;Heterogeneity;high risk;Hour;Individual;Inflammation;Inflammatory;Informatics;innovation;Intensive Care;ionization;Life;Lipids;Liquid substance;Lung;lung injury;Machine Learning;Mass Spectrum Analysis;Measures;Mechanical ventilation;metabolomics;Methods;Minority;Modeling;Molecular;Molecular Profiling;mortality;mortality risk;multidisciplinary;novel;Outcome;Patients;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Plasma;Population;primary outcome;prognostic;prognostic value;prospective;protein profiling;Proteins;Proteomics;Pulmonary Edema;Qualifying;receptor for advanced glycation endproducts;recruit;Reporting;Research;Research Personnel;Respiratory Failure;Risk;risk stratification;Sample Size;Sampling;secondary outcome;Severities;System;systemic inflammatory response;Technology;Testing;therapeutic target;treatment strategy;Ventilator

PROJECT_TITLE: Molecular characterization of pulmonary edema: a window to an injured lung

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The human microbiome plays a vital role in health and disease; however, the ways in which the bacterial guests interact with and affect the human host at a molecular level are poorly understood. Here, we propose to use a chemically guided approach to uncover how bacterial transformations of host- and diet-derived metabolites affect host physiology, and in particular, host metabolism, immune response, and neurological function. The research will shed light on fundamental processes underlying obesity and type 2 diabetes, inflammatory bowel diseases, and steroid-modulated mood disorders and will help lay the groundwork for the rational manipulation of the microbiome to treat these conditions.

PI_NAMEs: DEVLIN, ABIGAIL SLOAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;Anabolism;Automobile Driving;Bacteria;bacterial metabolism;Bacterial Transformation;Behavior;Bile Acids;Biological;Biology;Chemicals;Chemistry;chemoproteomics;Clinical;comparative;Diet;Disease;Enzymes;Goals;Grant;gut bacteria;Health;host microbiota;Human;Human Microbiome;Immune response;improved;in vivo;Inflammatory Bowel Diseases;Laboratories;Metabolism;metabolomics;microbial;microbiome;microbiome research;Molecular;Mood Disorders;Nervous System Physiology;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pathway interactions;Physiology;Play;Process;Production;programs;Research;Role;Signaling Molecule;small molecule;Steroids;United States National Institutes of Health;Vitamins;Work

PROJECT_TITLE: Human microbiome metabolites in health and disease

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


PI_NAMEs: SAHA, KRISHANU  (contact)

PROJECT_TERMS: Acceleration;Address;Alleles;Animal Model;Animals;autosome;basolateral membrane;biological systems;Calcium;Cell Separation;Cellular Assay;cellular targeting;Characteristics;Chloride Channels;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;Custom;Degenerative Disorder;Development;Development Plans;Disease;disease model;Dominant-Negative Mutation;Ensure;experience;Feedback;fluorescence imaging;Formulation;Functional disorder;functional restoration;Future;Genes;Genetic Engineering;genome editing;genome editor;Genotype;Goals;Guide RNA;Human;human induced pluripotent stem cells;improved;Individual;induced pluripotent stem cell;Inherited;insertion/deletion mutation;Investigational Drugs;Lead;lead candidate;Learning;Link;macula;Mediating;meetings;Messenger RNA;Missense Mutation;Modeling;Monitor;monomer;mutant;Mutation;nanocapsule;next generation sequencing;nonhuman primate;Nonsense Codon;Nonsense-Mediated Decay;novel;off-target site;Optical Coherence Tomography;Organoids;Pathogenicity;Patients;Photoreceptors;pre-clinical;pre-Investigational New Drug meeting;Process;programs;Proteins;Protocols documentation;Publishing;Rapid screening;Reporter;Retina;Ribonucleoproteins;Safety;scale up;Silicon Dioxide;somatic cell gene editing;Structure of retinal pigment epithelium;System;Testing;tool;Transcript;Transfection;translational applications;Vision;Vitelliform macular dystrophy;Work

PROJECT_TITLE: Streamlined development of an IND with the silica nanocapsule loaded with Cas9 genome editors to disrupt the dominant BEST1 mutant allele


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: RIVERSIDE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative The funding of this competitive renewal of the research training program will enable continuous training of next- generation scientists working in the area of environmental health and toxicology.

PI_NAMEs: WANG, YINSHENG  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Research Training in Environmental Toxicology


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The proposed basic research is relevant to public health because it focuses on a fundamental step in lung cancer metastasis: invasion. The work will lay the foundation for the development of new strategies to prevent and treat lung cancer morbidity and mortality.

PI_NAMEs: MENDOZA, MICHELLE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actins;Adenocarcinoma Cell;Affect;American;Basic Science;Biological Assay;Biosensor;cancer cell;Carcinoma;Cell Line;Cell Physiology;Cells;Computer Models;Data;Development;Disease;Dyspnea;Embryo;Extracellular Matrix;Extracellular Matrix Proteins;ezrin;Fibroblasts;flexibility;Foundations;Glioma;Goals;HSV glycoprotein C;Human;Human Cell Line;Immunofluorescence Immunologic;improved;In Situ;In Vitro;in vivo;innovation;Integrins;Intervention;Invaded;Isogenic transplantation;Knowledge;Lesion;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Membrane;Mesenchymal;Messenger RNA;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;mouse model;Mus;mutant;Mutation;Myofibroblast;Neoplasm Metastasis;neoplastic cell;Nodule;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;Pain;pancreatic cancer model;Pathway interactions;Patients;Periodicity;Phosphorylation;Phosphorylation Site;Phosphotransferases;prevent;Process;Production;prognostic;prognostic value;programs;PTK2 gene;Public Health;Radiation therapy;Recurrence;Regulation;Research;Respiration;response;Sampling;Signal Transduction;Slice;Source;Spatial Distribution;Stains;Stimulus;Stretching;targeted treatment;Tenascin;Testing;The Cancer Genome Atlas;Tissues;tumor;Tumor Cell Invasion;tumor growth;tumor initiation;Work;Xenograft procedure

PROJECT_TITLE: Cancer invasion: reciprocity between the extracellular matrix and intrinsic ERK signaling

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: Relevance to Human Health Understanding the pathophysiology and development of new therapeutics for ALS, ALS/FTD and FTD has been an enormous challenge. Recently the development of human disease induced pluripotent cell lines representing the natural disease in the most relevant cell types, motor neurons and glia, along with rodent and drosophila models, representing an in vivo system, provides unprecedented tools to 1) study the underlying disease process, 2) allow for identification of disease markers of pathology and of drug actions and 3) provide critical tools for future drug discovery and drug action validation. These ALS/FTD model systems, especially those derived from sporadic ALS patients, along with parallel studies of astroglia, combined with analysis of human brain tissues will be useful to compare common and uncommon pathways between ALS and other neurodegenerative models.

PI_NAMEs: ROTHSTEIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Aging;ALS patients;Astrocytes;Biological Models;Biology;brain tissue;C9ALS;C9ORF72;candidate identification;Cell Line;cell type;Cellular biology;Data;Defect;Degenerative Disorder;Dementia;Dendrites;Development;Disease;Disease Marker;Drosophila genus;drug action;drug discovery;Educational process of instructing;Elements;fly;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Future;Health;Human;human disease;Huntington Disease;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Injury;insight;Learning;Link;Location;loss of function;Modeling;molecular subtypes;Motor Neurons;mouse model;mutant;Mutation;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;Neuroglia;Neurons;novel therapeutics;Nuclear;Nuclear Pore;Nuclear Pore Complex;nucleocytoplasmic transport;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Process;Property;protein TDP-43;Proteins;repaired;Rodent;sporadic amyotrophic lateral sclerosis;Subgroup;Synapses;System;Therapeutic;therapeutic candidate;tool;Validation

PROJECT_TITLE: Nuclear and Glial Dysfunction in Neurodegeneration


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: RELEVANCE TO PUBLIC HEALTH Brain blood flow declines in aging and in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD). We have new evidence showing a critical role for Piezo1 (an ion channel activated by blood flow/shear) in blood flow regulation in the brain and further evidence that this ion channel is impaired with amyloidosis, a common occurrence in many forms of AD/ADRD. We now propose to 1) define the role of Piezo1 dysfunction in aging and AD/ADRD pathology and 2) determine if enhancing Piezo1 function can restore normal blood flow regulation and reduce pathology in the aged and AD/ADRD brain.

PI_NAMEs: MARRELLI, SEAN P (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;amyloid pathology;Amyloidosis;arteriole;behavior test;behavioral study;Biosensor;Blood flow;Blood Vessels;Brain;brain endothelial cell;brain health;Brain Pathology;Calcium;Cerebral Amyloid Angiopathy;cerebral amyloidosis;Cerebral endothelium;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;cerebrovascular pathology;Chronic;Cognition;Cognitive;cognitive performance;Data;Development;Encephalitis;Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;gain of function;Gene Expression Profile;Gene Expression Regulation;Gliosis;Hyperemia;hypoperfusion;Image;Impaired cognition;Impairment;improved;in vivo;Inflammation;Ion Channel;Ion Channel Gating;Knock-out;Laser Speckle Imaging;Learning;loss of function;Macrophage;Measures;Mediating;Membrane;Memory;Microglia;Modeling;mouse model;Mus;Mutation;new therapeutic target;novel;novel strategies;Pathology;Patients;Perfusion;Peripheral;pharmacologic;Piezo 1 ion channel;Public Health;quantitative imaging;recruit;Regulation;resilience;resilience in aging;response;Rest;Role;sex;Signal Transduction;single nucleus RNA-sequencing;Stretching;Testing;Tg2576;therapeutic target;two-photon;Up-Regulation;Vasodilation;white matter;white matter injury

PROJECT_TITLE: Modifying endothelial Piezo 1 function to improve brain perfusion in AD/ADRD


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Pediatric;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The UC San Diego Womens Reproductive Health Research (WRHR) Career Development Program provides rigorous interdisciplinary research training and career development to prepare physician-scientists in Obstetrics and Gynecology to become leaders in Women's Health research. Exceptional junior faculty OB/GYNs with MD, MD/PhD, MD/MPH, and other dual degrees participate in a structured program that includes relevant didactic training, as well as intensive project-based training in basic, translational, or clinical research under the guidance of a well-established primary research mentor with domain expertise and an Individual Mentorship Team, with oversight by Internal and External Advisory Committees. The world-class intellectual environment at the University of California, San Diego enables the UC San Diego WRHR program to offer WRHR scholars access to a team of experienced and dedicated faculty mentors and collaborators with diverse but complementary expertise, primarily from the Departments of OB/GYN and Reproductive Sciences, Medicine, Pediatrics, Family Medicine, Pathology, and Public Health.

PI_NAMEs: GYAMFI-BANNERMAN, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Academic achievement;Address;Advisory Committees;Appointment;Area;Basic Science;Biometry;career;career development;Career Mobility;Clinic;Clinical;Clinical Research;Competence;data management;Development;Educational process of instructing;Educational workshop;Effectiveness;Embryology;Ensure;Environment;Epidemiology;Ethics;experience;Faculty;Family Planning;Female;Grant;Gynecologic Oncology;Individual;Informatics;Instruction;Interdisciplinary Study;International;Leadership;Medical;Medicine;member;Mentors;Mentorship;mid-career faculty;Monitor;Pelvis;Perinatal;Phase;Physicians;Physiology;prenatal;professor;Program Development;programs;Qualifying;recruit;Reproductive Endocrinology;Reproductive Sciences;Research;research and development;Research Personnel;Research Training;Review Committee;Scientist;social;success;Time;Training;Translating;Translational Research;Women's Health;women's reproductive health;Work;Writing

PROJECT_TITLE: UC San Diego Womens Reproductive Health Research Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The Training Program in Alzheimer's Disease and AD-Related Dementias at Indiana University School of Medicine (IUSM) will train 4 predoctoral and 4 postdoctoral trainees in the biology of these disorders and in the use of contemporary investigative methodologies with an emphasis on the integration of data science and -omics approaches. The program integrates the multidisciplinary resources of several NIA-supported Centers at IUSM, including the MODEL-AD and the Alzheimer's Disease Drug Discovery Centers. The 25 participating faculty support the trainees in basic, translational, and clinical research to produce the skilled workforce required for developing treatments for AD and related dementias.

PI_NAMEs: LAMB, BRUCE T;LANDRETH, GARY E. (contact);SAYKIN, ANDREW J

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Grant;Indiana;Training;Universities

PROJECT_TITLE: Training Grant on Alzheimer's Disease and ADRD at Indiana University


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This proposed project will improve the measurement of HbA1c for optimal clinical and diagnostic use. Preservation of beta cell function in type 1 diabetes has been identified as an important goal in delaying progression of the disease at onset and also for therapeutic intervention. Accurate, standardized measurement of C-peptide will aid in this goal and is also the subject of this proposal.

PI_NAMEs: KABYTAEV, KUANYSH  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;American;Beta Cell;Biological;Biological Assay;Blood Glucose;Blood specimen;Blood Vessels;C-Peptide;Calibration;Capillary Electrophoresis;Caring;Cell Physiology;Certification;Chronic;Chronic Disease;Clinical;Clinical Chemistry;Clinical Research;college;Complications of Diabetes Mellitus;Data;Data Analyses;Development;diabetes control;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic tool;Disease;Disease Progression;effectiveness evaluation;Evaluation;Eye;Fostering;Freezing;glycemic control;Glycosylated hemoglobin A;Goals;Heart;Hemoglobin;high risk;Hyperglycemia;improved;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;International;Kidney;Laboratories;Manufacturer;Measurement;meetings;member;Methods;Monitor;Pathologist;Performance;Peripheral Nerves;Persons;preservation;programs;Publishing;Recommendation;Reporting;Research;Research Project Grants;Risk;Scheme;Site;Specific qualifier value;Specificity;Standardization;Testing;Therapeutic Intervention;United States National Institutes of Health;Update;Variant;web site;Whole Blood

PROJECT_TITLE: Standardization of C-Peptide and HbA1C Measurements Program


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The goal of the proposed research is to discover and produce bioactive natural products and analogs of less- studied microbes by developing new research strategies. In so doing, the research will directly impact the biomedical mission of the NIH by providing novel drug leads to address unmet medical needs.

PI_NAMEs: DING, YOUSONG  (contact)

PROJECT_TERMS: Address;Anabolism;analog;bioactive natural products;Bioinformatics;bioinformatics tool;Chemicals;design;drug development;drug discovery;Enzymatic Biochemistry;Enzymes;Family;functional genomics;Gene Cluster;Genome;genomic data;Goals;innovation;marine;Medical;Microbe;microbial;microbial genome;Microbial natural product;Mining;Mission;Natural product discovery;Natural Products;novel;novel therapeutics;Pharmaceutical Preparations;Production;programs;Research;Resources;Source;success;synthetic biology;Testing;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Accessing and expanding microbial bioactive chemical diversity by synthetic biology and new enzymology


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Tumor-stroma/immune cell signaling communications within tumor microenvironment (TME) play important roles in tumor development and responses to targeted and immunotherapies; whereas, the complex and essential signaling communications within TME remain mysteries. Herein, we aim to develop novel systems biology models, combining cutting edge technologies, i.e., artificial intelligence (AI) models, pooled-library crispr, single-cell RNA sequencing (scRNA-seq), and 3D scalable tumor-stroma/immune cell co-culture assays (tumor-on-a-chip), and state-of-the-art cancer genetic mouse models to uncover novel tumor-stroma/immune cell signaling communications. And, we will identify novel therapeutic targets, drugs/drug combinations, inhibiting the tumor-stroma/immune signaling communications, to improve treatment response of targeted and immunotherapies.

PI_NAMEs: LI, FUHAI  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: 3-Dimensional;angiogenesis;artificial intelligence model;Atlases;Biological Assay;cancer genetics;cell type;Cells;Chemoresistance;Coculture Techniques;Communication;Communities;Complex;CRISPR library;Data;Data Set;Development;Diagnosis;Disease;Drug Combinations;effective therapy;Feedback;Fibroblasts;Genetic;Genetic Transcription;Heterogeneity;Human;Immune;Immune signaling;Immunotherapy;improved;In Vitro;in vivo;Individual;Knock-out;Knowledge;Malignant Neoplasms;Measurable;Measures;migration;Modeling;Molecular Target;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Pharmaceutical Preparations;Play;Process;Proliferating;Research;Resources;response;restraint;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;success;Systems Biology;targeted treatment;Technology;Time;tool;Training;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-associated macrophages;Tumor-Associated Process;Validation

PROJECT_TITLE: Modeling and targeting tumor-immune signaling interactions in tumor microenvironment

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ATLANTA

ORG_NAME: BIOCIRCUIT TECHNOLOGIES, INC.

ORG_STATE: GA

PHR: Project Narrative Abnormal spinal reflexes impair walking and other motor functions in many people with incomplete spinal cord injury (SCI). New therapies are needed. Spinal reflex conditioning is a novel noninvasive therapy that modifies these spinal reflexes to reduce spasticity, eliminate limping, and increase walking speed. This project will result in a robust, validated, clinically practical reflex conditioning system that enables this powerful new therapy to complement traditional therapies and enhance functional recovery for people with SCI and other disorders.

PI_NAMEs: CLEMENTS, ISAAC PERRY (contact);THOMPSON, AIKO ;WOLPAW, JONATHAN RICKEL

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: abnormal reflex;Activities of Daily Living;Adoption;Adverse event;Affect;Aftercare;Algorithmic Software;animal data;automated algorithm;Baclofen;brain control;Categories;Chronic;Classification;Clinical;Clinical Research;clinical translation;Community Participation;Complement;Complex;Computer software;conditioning;Data;design;Development;Devices;Disease;effectiveness validation;efficacy trial;Ensure;Evaluation;Feedback;functional restoration;Future;Gait abnormality;Goals;H-Reflex;human data;Injury;Learning;Location;Locomotor training;Measures;Medical;Medical Device;Methods;Motor;motor function improvement;motor function recovery;motor impairment;movement practice;Muscle;Nerve;neural stimulation;Neuromuscular Diseases;neuromuscular stimulation;neurotechnology;novel;novel therapeutics;Operant Conditioning;Outcome;Pathway interactions;Patients;Peripheral Nerve Stimulation;Persons;pharmacologic;Phase;phase 2 study;Population;Posterior Tibial Nerves;Protocols documentation;Quality of life;Records Controls;Recovery;Recovery of Function;Reflex action;Regulatory Pathway;Reporting;Research;Research Personnel;Risk Assessment;Safety;Signal Transduction;Site;software systems;Soleus Muscle;South Carolina;spasticity;Spinal cord injury;spinal reflex;Stroke;Structure;System;Systems Integration;targeted treatment;Technology;Testing;Therapeutic;Time;traditional therapy;Training;Treatment Protocols;Universities;usability;visual feedback;walking speed

PROJECT_TITLE: Spinal Reflex Conditioning System for Enhancing Motor Function Recovery After Incomplete Spinal Cord Injury


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ANCHORAGE

ORG_NAME: SOUTHCENTRAL FOUNDATION

ORG_STATE: AK

PHR: PROJECT NARRATIVE The older Alaska Native/American Indian (ANAI) population is increasing at more than twice the rate of the general population and has higher rates of chronic illness. Yet, older ANAIs are only half as likely to have advance directives (AD), indicating a need for advance care planning (ACP) to ensure that care aligns with patients’ values and goals. This project will implement and evaluate a culturally tailored ACP intervention to increase ADs among seriously ill ANAI patients and provide evidence for improving palliative and end-of-life care delivery to this rapidly rising population of Americans.

PI_NAMEs: SHAW, JENNIFER LYN (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Adult;Advance Care Planning;advanced directive;Age;Alaska;Alaska Native;Alaska Native population;American;American Indian Population;Anxiety;care delivery;Caring;Cessation of life;Chronic;Chronic Disease;Cirrhosis;Client satisfaction;clinical practice;Cluster randomized trial;Communication;Communities;community academic partnership;community engagement;Consensus;Consolidated Framework for Implementation Research;cost;Data;Diabetes Mellitus;disability;Disparity;Documentation;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Electronic Health Record;Emotional;end of life;end of life care;evidence base;Family;follow-up;Foundations;future implementation;General Population;Goals;Grief reaction;Health;Health system;Healthcare Systems;Heart Diseases;high risk;Hypertension;implementation intervention;implementation science;implementation strategy;implementation study;Improve Access;improved;improved outcome;innovation;Institute of Medicine (U.S.);Integrated Health Care Systems;Intervention;Kidney Diseases;Life;Measures;Medical;member;Mental Depression;Methods;multidisciplinary;older adult;older patient;Outcome;palliative;Palliative Care;Patient Preferences;Patient-Focused Outcomes;Patients;peer;Persons;Pneumonia;Population;Population Heterogeneity;Primary Care;primary care clinic;primary care patient;primary care practice;primary care provider;primary outcome;process evaluation;programs;Provider;Race;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Respiratory Disease;routine care;Sampling;secondary outcome;Specific qualifier value;Spirituality;Stroke;Support System;surrogate decision maker;System;Taboo;Testing;tool;Training;treatment as usual;tribal health;tribal healthcare;Tribes;United States;Work

PROJECT_TITLE: Jumpstarting Culturally-informed Advance Care Planning with ANAI People in Primary Care

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Understanding the generation and maintenance of immunological memory is the foundation of effective vaccine development. We will contribute to this understanding by developing quantitative models for how immune responses are generated and boosted, and how immunological memory is maintained. This quantitative framework will help in the development of universal vaccines that provide broad protection against influenza. !

PI_NAMEs: AHMED, RAFI ;ANTIA, RUSTOM NOSHIR (contact);ELLEBEDY, ALI HASSAN;HANDEL, ANDREAS ;THOMAS, PAUL G.

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Response;Antigens;Attenuated;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biological Models;Blood Cells;Bone Marrow;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Complication;computerized tools;Data;Data Analyses;Data Set;Deuterium Oxide;Development;Educational workshop;Epitopes;Evolution;experimental study;Exposure to;Foundations;Generations;Goals;Hemagglutinin;Human;human data;Humoral Immunities;Immune;Immune response;Immunity;Immunization;Immunologic Memory;Immunological Models;In Vitro;in vivo;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H2N2 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza Hemagglutinin;Influenza vaccination;influenza virus strain;influenzavirus;Label;Location;long term memory;Longevity;Maintenance;Masks;mathematical model;Memory;Memory B-Lymphocyte;migration;Modeling;mouse model;Mus;neutralizing antibody;pandemic disease;Passive Transfer of Immunity;Phenotype;Plasma Cells;Play;Population;Proteins;response;Role;seasonal influenza;Seasons;Sequence Analysis;Serum;simulation;stem;stem cells;symposium;T cell response;T memory cell;T-cell diversity;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Time;tool;tool development;universal influenza vaccine;universal vaccine;user-friendly;Vaccination;vaccination strategy;vaccine development;vaccine trial;Vaccines;Variant;Virus;Virus Diseases;Visualization;Yellow Fever;Yellow Fever Vaccine;Yellow fever virus

PROJECT_TITLE: DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PHR: PROJECT NARRATIVE Although the Human Immunodeficiency Virus (HIV) has been extensively studied for nearly two decades, we still do not fully understand the HIV replication cycle. We have identified the sphingomyelin hydrolase, neutral sphingomyelinase-2 (nSMase2), as an obligate cellular regulator of late-stage viral assembly. In this application we propose to determine the molecular mechanisms by which nSMase2 regulates HIV assembly and will validate the critical role for this cellular enzyme using molecular interference and structurally novel small molecule inhibitors of nSMase2 in a humanized mouse model of HIV infection.

PI_NAMEs: HAUGHEY, NORMAN J (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Animal Model;Animal Testing;Animals;Binding;Biogenesis;biophysical properties;Brain;Cell membrane;Ceramides;Cholesterol;Data;Defect;Electrostatics;Enzymes;Event;Exhibits;experimental study;gag Gene Products;Generations;Genetic;Goals;HIV;HIV Budding;HIV envelope protein;HIV Infections;HIV-1;humanized mouse;Hydrolase;in vivo;Infection;inhibitor;Knowledge;Lateral;Life Cycle Stages;Link;Lipid Bilayers;Lipids;Membrane;Membrane Microdomains;Molecular;mouse model;Mus;Myristic Acids;novel;particle;Pharmaceutical Preparations;pharmacologic;Phase Transition;Phosphatidylserines;Plasma;Play;prevent;Process;Production;Protein Precursors;Rattus;Research;Role;saturated fat;Shapes;Site;small molecule inhibitor;Sphingomyelinase;Sphingomyelins;Sterols;Testing;Time;Viral Load result;viral rebound;Virion;Virus Assembly;Virus Replication

PROJECT_TITLE: A Sphingomyelin Hydrolase Regulates the Late Stages of HIV Assembly and Budding

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative The proposed project aims to investigate the brain network interactions supporting memory for the specific details of events. We will examine the network processes that contribute to the binding and specificity of event details, building a model explaining how these key aspects of memory quality vary across events and across individuals. Delineating these mechanisms will improve our ability to understand and intervene on qualitative memory changes associated with psychiatric and neurological disorders, such as reductions in memory specificity observed in affective disorders.

PI_NAMEs: RITCHEY, MAUREEN  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: analytical method;Area;Behavioral;Binding;Brain;Brain region;Cognitive;Communication;Complex;design;Dimensions;dorsal visual stream;Episodic memory;Event;Exhibits;Experimental Designs;Functional Magnetic Resonance Imaging;Goals;Hippocampus;improved;Individual;Individual Differences;Investigation;Lateral;Link;Measures;Medial;member;Memory;Mental disorders;mental representation;Modeling;Mood Disorders;Nervous System Disorder;novel;Parietal;Parietal Lobe;Pathway interactions;Pattern;Performance;Persons;Process;recruit;Research;Retrieval;Role;Specificity;Structure;Techniques;Testing;Transcranial magnetic stimulation;ventral visual stream;Work

PROJECT_TITLE: Brain networks predicting variability in episodic memory quality

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Current treatments for advanced colorectal cancer have limited efficacy, in part because they do not target the cancer stem cell populations that drive tumor relapse, chemoresistance, and metastasis. This project investigates the functions of aldehyde dehydrogenase 1B1 (ALDH1B1) in colorectal cancer stem cells and the potential of ALDH1B1 inhibitors as new targeted therapies.

PI_NAMEs: CHEN, JAMES K (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: absorption;Adherent Culture;Aftercare;aldehyde dehydrogenases;Angiogenesis Inhibitors;antagonist;Antimitotic Agents;Biochemical;Biochemistry;Biological Assay;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;cancer stem cell;cancer subtypes;cancer therapy;Cell Line;Cell Maintenance;Cell model;Cells;Cellular biology;Cessation of life;Chemicals;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;colon cancer cell line;colon cancer patients;Colon Carcinoma;colon growth;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Complex;Development;Diagnosis;Differentiation and Growth;Disease;Drug Targeting;effective therapy;Enzymes;Epidermal Growth Factor Receptor;Exhibits;Gastroenterology;Genes;Goals;Guanidines;Immunodeficient Mouse;Immunotherapy;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;insight;Intestines;Investigation;Investigational Drugs;Knock-out;Lead;Life Style;lipid metabolism;Lipid Peroxidation;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metastatic colorectal;Mitochondria;Molecular;molecular subtypes;Mus;Mutagenesis;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Normal tissue morphology;Oncogenic;Operative Surgical Procedures;Outcome;oxidation;Pathway interactions;Patients;Periodicity;Pharmaceutical Chemistry;pharmacologic;Population;pre-clinical;Preventive screening;Property;Protein Isoforms;Relapse;Reporting;Research;Resected;response;Retina;Roentgen Rays;Role;scaffold;self renewing cell;Signal Transduction;spheroids;stem cell biology;stem cell biomarkers;stem cell function;stem cell population;stem cell survival;stem cells;stemness;structural biology;Structure;Survival Rate;Synthesis Chemistry;Therapeutic;therapeutic target;Time;tool;transcriptome;transcriptomic profiling;Tretinoin;tumor;tumor growth;Tumor Promotion;tumor xenograft;tumorigenesis;Tumorigenicity;western diet;Work;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: Targeting colorectal cancer stem cells with ALDH1B1 antagonists

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

PHR: PROJECT NARRATIVE The proposed research has relevance to public health through its focus on the impact that stress has on how the brain learns and remembers. In particular, the proposed studies are expected to improve our understanding of stress susceptibility and resilience factors, including differences in the way the brain’s emotional memory center, the amygdala, responds to stress in males and females.

PI_NAMEs: COLOM LAPETINA, JOSE  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;acute stress;alcohol use disorder;Alcohols;Amygdaloid structure;Animals;Association Learning;Basic Science;Brain;Calcium;Cells;Characteristics;Code;comorbidity;conditioning;Coupled;Cues;Data Analyses;deep sequencing;Desire for food;Development;Diagnosis;Disease;drug of abuse;Drug usage;Emotional;Event;Exhibits;experience;Exposure to;Extinction;fear memory;Fellowship;Female;FOS gene;Fright;Functional disorder;Genetic;Goals;Handedness;Heavy Drinking;Heterogeneity;Human;Image;immunoreactivity;improved;in vivo;in vivo calcium imaging;in vivo imaging;Inbred Mouse;Individual;insight;Learning;Left;Maintenance;male;Measures;Mediating;member;Memory;memory recall;Mental disorders;Military Personnel;Modeling;Molecular;Mus;Negative Valence;neural;Neurobiology;Neurons;neurophysiology;optogenetics;Output;Performance;Persons;Pharmaceutical Preparations;Phase;Phenotype;Photons;Population;Positive Valence;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Predisposition;Prevalence;Protocols documentation;Public Health;recruit;Research;resilience;resilience factor;Resistance;restraint;restraint stress;Risk;Rodent;sex as a biological variable;Stress;stress disorder;stress resilience;stressor;Structure;Study models;Substance Use Disorder;Symptoms;Synapses;System;Techniques;Testing;Therapeutic;Tissue-Specific Gene Expression;Training;transcriptomics;Trauma;traumatic event;Vulnerable Populations;Woman;Work

PROJECT_TITLE: The Impact of Individual Vulnerability to Stress on Alcohol and Drug Seeking


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: NARRATIVE Bipolar I disorder typically emerges during adolescence or young adulthood. Using longitudinal study of ventral brain network in youth with or without a familial risk for bipolar I disorder, and with or without childhood maltreatment, we propose to define how brain developmental abnormalities evolve to produce bipolar I disorder.

PI_NAMEs: DELBELLO, MELISSA P (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 21 year old;Adolescence;Adult;Affective;Amygdaloid structure;Anxiety;Anxiety Disorders;Attention deficit hyperactivity disorder;Behavior;Behavioral;Bipolar Disorder;Bipolar I;Brain;Brain region;Characteristics;Child Abuse and Neglect;Clinical;Cognitive;Computer Models;Corpus striatum structure;Data;Development;Diffusion Magnetic Resonance Imaging;Disease;early life adversity;early life stress;Early-life trauma;emotion dysregulation;emotion regulation;Emotional;Event;experience;Exposure to;Failure;Family;Family history of;Feedback;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;General Population;Globus Pallidus;Goals;Heritability;Hypersensitivity;Image;Impairment;Individual;Inherited;Lead;Link;Longitudinal Studies;Machine Learning;Manic;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mind;mood symptom;Moods;Motivation;neural;Onset of illness;Outcome;Pathway interactions;Persons;Phenotype;Prefrontal Cortex;prevent;psychosocial;Recording of previous events;recruit;Recurrence;Reporting;response;reward processing;Rewards;Risk;Risk Factors;Site;Subgroup;substance misuse;Substance Use Disorder;suicidal behavior;Suicide;Symptoms;Syndrome;System;Testing;Thalamic structure;Time;Unipolar Depression;young adult;Youth

PROJECT_TITLE: 2/2-Neurodevelopmental and Clinical Trajectories of Youth at Risk for Bipolar Disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Humans cannot repair injury or cell loss in the nervous system very well, so new therapeutic approaches could improve health outcomes after stroke, neurodegenerative disease, and traumatic injury. Our group seeks to understand how successful nervous system regeneration occurs in nature, with the goal of uncovering fundamental principles or even specific pathways that could be manipulated to improve regenerative therapies. The goal of this project is to use worms called planarians with extraordinary regenerative ability to reveal how neurons are born after injury.

PI_NAMEs: ROBERTS-GALBRAITH, RACHEL HELEN (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acetylcholine;Adult;adult stem cell;Animals;Anterior;Automobile Driving;Behavior;Behavioral Assay;Biological Assay;Brain;brain tissue;cell injury;cell type;Cells;Central Nervous System;Cephalic;Complex;Cues;Development;Dopamine;dopaminergic neuron;Dorsal;Failure;feeding;Fresh Water;functional restoration;gamma-Aminobutyric Acid;Ganglia;Genes;Glutamates;Goals;Health;Homeostasis;Human;improved;in vivo;Injury;injury and repair;innovation;ischemic injury;Laboratories;Location;Maintenance;model organism;Modeling;Molecular;Movement;Muscle;Natural regeneration;Nature;Nerve;Nerve Regeneration;Nerve Tissue;Nervous System;neural;neural repair;Neurobiology;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuron regeneration;Neurons;Neuropeptides;Neurotransmitters;novel therapeutic intervention;Organ;Outcome;Partner in relationship;Pathway interactions;Patients;Pattern;Peripheral Nervous System;Pharyngeal structure;Planarians;Platyhelminths;Pluripotent Stem Cells;Positioning Attribute;post stroke;Predatory Behavior;reconstitution;Recovery;regeneration model;regenerative;Regenerative research;regenerative therapy;Regulation;repaired;Research;response;response to injury;Rest;Role;Serotonin;Signal Induction;Signal Transduction;Spinal Cord;Spinal cord injury;stem cell differentiation;stem cell therapy;Stem cell transplant;Stimulus;Stroke;Structure;Testing;tissue regeneration;Tissues;transcription factor;Traumatic injury;Work;wound

PROJECT_TITLE: Mechanisms Driving Regenerative Neurogenesis in Planarians

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: Overall Component The proposed research is relevant to public health because understanding leptospiral virulence factors and the host response to leptospirosis is expected to give rise to new types of rapid biomarker diagnostic and triage tools to identify serious infections at an early stage when antibiotics and other interventions can prevent and/or treat critical illness including fatal hepatorenal failure. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering creative discoveries and innovative research strategies as a basis for ultimately protecting and improving health.

PI_NAMEs: HAAKE, DAVID A (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acute;Adherens Junction;adjudication;Animal Model;Animals;Antibiotics;arm;Bacterial Adhesins;Basic Science;biobank;Biological Markers;cadherin 5;Chronic;chronic infection;Clinical;Clinical Data;clinical research site;Collaborations;Creativeness;Critical Illness;Data;Development;Diagnostic;diagnostic biomarker;diagnostic tool;Disease;Disease Outcome;Disease susceptibility;Ecology;Endothelial Cells;Endothelium;Epidemiology;Etiology;Failure;Fever;field study;follow-up;Fostering;genetic manipulation;Genetic Transcription;Genome;genome-wide;Goals;Hamsters;Health;Human;Immune response;improved;In Vitro;in vitro testing;in vivo;Infection;Inflammasome;inflammatory marker;Inflammatory Response Pathway;Innate Immune Response;innovation;insight;Interdisciplinary Study;Interferon Type I;Interleukin-1 beta;International;Intervention;Invaded;Leptospira;Leptospira interrogans;Leptospirosis;Macrophage;medical schools;Mission;monolayer;mortality;Mus;Nicaragua;Occupational;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Phagocytes;Phenotype;predictive tools;Predisposition;prevent;Prognostic Marker;prognostic tool;programs;prospective;Public Health;Recreation;Research;Research Personnel;Resource-limited setting;response;Role;Rural;Sampling;Science;Severities;Severity of illness;Site;Small RNA;Sri Lanka;Structure;Study models;Tanzania;Testing;tool;Translational Research;Translations;Triage;United States National Institutes of Health;Untranslated RNA;Validation;Virulence;Virulence Factors;virulence gene;Wisconsin;Work

PROJECT_TITLE: Host-Pathogen Interaction in Leptospirosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Administrative Coordination;Animal Model;Basic Science;Biological Assay;Biometry;Budgets;Calendar;California;Cell Line;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;Complex;conflict resolution;Data;Development;Education;Ensure;Environment;experience;field study;Fostering;Funding;Goals;Grant;Human;Human Resources;Immune response;Immunology;Individual;Institution;inter-institutional;International;International Aspects;Investigation;Journals;Leadership;Leptospirosis;Link;Location;Los Angeles;Maintenance;Mediating;medical schools;meetings;member;Methodology;Methods;multidisciplinary;mutant;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Office of Administrative Management;operation;Participant;pathogen;Pathway interactions;Problem Solving;Procedures;Productivity;programs;Publications;Quality Control;Reagent;Regulation;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Sampling;skills;Specimen;Statistical Data Interpretation;Structure;success;Sum;Supervision;synergism;timeline;tool;Translational Research;translational research program;United States National Institutes of Health;Universities;Update;videoconference;virulence gene;Wisconsin

PROJECT_TITLE: Administrative Core


PI_NAMEs: RELLER, MEGAN ELIZABETH (contact)

PROJECT_TERMS: Acute;Affect;Agreement;biobank;biomarker development;Classification;Clinical;Clinical Data;clinical infrastructure;Clinical Microbiology;Clinical Research;clinical research site;Collection;Communicable Diseases;cost;Data;data sharing;Detection;Diagnosis;Diagnostic;diagnostic platform;Diagnostic tests;diagnostic tool;Disease;Doctor of Philosophy;Domestic Partners;Enrollment;Ensure;Etiology;evidence base;experience;Fever;Gene Targeting;Genes;Genetic Transcription;global health;Goals;Immune;Immune response;improved;Infection;Inflammatory Response;Infrastructure;Institution;International;Invaded;Lead;Leptospira;Leptospirosis;Longitudinal cohort study;Molecular;molecular marker;Morbidity - disease rate;mortality;Nicaragua;novel;novel diagnostics;Paris, France;pathogen;Pathway interactions;Pattern;Peptides;Phagocytes;point of care;point-of-care diagnosis;predictive tools;Program Research Project Grants;programs;Protocols documentation;Reference Standards;Research;Research Infrastructure;research study;Resource Sharing;Resource-limited setting;Resources;response;sample collection;Sampling;Severities;Severity of illness;Shipping;Site;Sri Lanka;Standardization;Tanzania;Testing;Translational Research;Universities;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: International Clinical Administrative Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Pediatric;Precision Medicine

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed research is relevant to public health because it aims to determine the best treatment approach to ameliorate grammatical weaknesses, a core deficit, of young children with developmental language disorder. Findings from this study will help to significantly improve the clinical services offered to children with language impairment. The project is focused on improving the long-term grammatical weaknesses of children with significant language impairment and is thus, central to NIDCD’s mission to improve the lives of individuals with communication disorders.

PI_NAMEs: FINESTACK, LIZBETH H (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 6 year old;8 year old;Adolescent;alternative treatment;Awareness;Behavior Therapy;Child;Clinical;Clinical Services;Combined Modality Therapy;Communication impairment;comparative efficacy;comparison intervention;Complex;Conscious;Decision Making;design;Development;Educational process of instructing;efficacy evaluation;efficacy study;Evaluation;executive function;experience;improved;Individual;innovation;Instruction;Intervention;Language;Language Development;Language Development Disorders;language impairment;Learning;Maintenance;Measures;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;non-verbal;novel;Outcome;Participant;Pattern;Performance;personalized approach;personalized intervention;Phase;post intervention;Prediction of Response to Therapy;Public Health;Randomized;randomized, clinical trials;Research;Research Design;Research Personnel;Sampling;School-Age Population;Sequential Multiple Assignment Randomized Trial;skills;Standardization;success;syntax;Time;treatment duration;treatment group;treatment optimization;trial design

PROJECT_TITLE: Evaluation of an Explicit Approach to Teach Grammatical Forms to Children with Language Impairment

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PI_NAMEs: MONOT, MARC  (contact)

PROJECT_TERMS: Alleles;Bacteria;Binding Proteins;Binding Sites;Bioinformatics;Biological Assay;Biology;Blood;Cadherins;ChIP-seq;Collection;comparative;Core Facility;CRISPR interference;Development;Dinucleoside Phosphates;DNA;DNA Binding;Endothelium;Engineering;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome database;genome sequencing;genome-wide analysis;Genomic Library;Genomics;Goals;Hamsters;Human;In Vitro;indexing;Individual;innovation;International;knock-down;Knock-out;Laboratories;Leptospira;Leptospirosis;leucine-rich repeat protein;Libraries;Macrophage;Methods;methylome;Methyltransferase;Molecular;Mus;mutant;Order Spirochaetales;Oxidative Stress;Paris, France;pathogen;Phylogenetic Analysis;Plasmids;programs;Proteins;Research;Resources;Reverse Transcription;RNA;Sampling;Science;Services;Site;Subcutaneous Tissue;success;Technology;tool;Transcription Coactivator;transcriptome sequencing;transcriptomics;transposon sequencing;Work

PROJECT_TITLE: Science Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Human response to Influenza virus infection varies dramatically between individuals, from mildly symptomatic to death. We will systematically measure and model the innate immune response to IAV at the molecular network level: from host-virus protein-protein interactions through cellular signal transduction to changes in gene expression in human cells. The resulting mathematical model will help identify network vulnerabilities to be exploited for IAV therapy and help predict differences in IAV response in the human population.

PI_NAMEs: MARAZZI, IVAN  (contact);MIRALDI, EMILY

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Affinity Chromatography;Algorithms;Alleles;antimicrobial;Architecture;ATAC-seq;Attenuated;Automobile Driving;Binding;Biological Models;cell behavior;cell type;Cells;Cessation of life;Chromatin;Chromatin Structure;cytokine;Data;Data Set;deep learning;deep learning model;design;Differential Equation;Disabling;Disease;DNA Sequence;Engineering;Ensure;Epigenetic Process;Epithelial Cells;Epithelium;Experimental Designs;Experimental Models;experimental study;Flow Cytometry;flu;forest;Future;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Epistasis;Genetic Models;Genetic Polymorphism;genetic predictors;Genetic Risk;Genetic Transcription;Genome;Genomics;Genotype;global health;Goals;Heterogeneity;Hi-C;high dimensionality;Host Defense;Human;human disease;human model;human pathogen;Immune;Immune response;improved;In Vitro;in vivo;Individual;Infection;Influenza A virus;influenza infection;influenzavirus;Innate Immune Response;Interferon Type I;Interferon-beta;Joints;Knowledge;Learning;Lung;Maps;Mass Spectrum Analysis;mathematical model;Measurement;Measures;Mediating;Modeling;Molecular;molecular modeling;Molecular Target;mortality;mouse model;Mouse Strains;Mus;mutant;network models;Outcome;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Pattern recognition receptor;Population;predictive modeling;prevent;Prize;promoter;protein protein interaction;Proteins;reconstruction;Reporter;response;risk variant;Role;Severity of illness;Signal Pathway;Signal Transduction;Signaling Molecule;simulation;single cell ATAC-seq;single-cell RNA sequencing;Small Interfering RNA;Structure of parenchyma of lung;System;Techniques;Testing;Therapeutic;Time;Tissue Model;tool;Tracheal Epithelium;Training;Transcription Elongation;transcription factor;transcription factor USF;Transcription Initiation;transcription termination;transcriptome sequencing;Untranslated RNA;Validation;Viral;Viral Proteins;Virulence;Virus;virus genetics

PROJECT_TITLE: Dynamic regulatory network models of human response to influenza virus


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases

PROJECT_TERMS: Accidents;acute infection;Animal Model;Antigens;Blood;Bone Marrow;California;Candidate Disease Gene;chronic infection;Collaborations;Data;Defect;Disease Reservoirs;Endothelium;Evolution;Exposure to;Failure;fitness;Genes;Genetic Transcription;Genomics;Goals;Hamsters;Health;Hemorrhage;Human;human disease;Immune response;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammasome;innate immune pathways;interest;Interferon alpha;Interferon Type I;Interferons;Interleukin-1 beta;Iron;Kinetics;knock-down;Leptospira;Leptospira interrogans;Leptospirosis;Libraries;Liver;Los Angeles;Macrophage;Membrane Proteins;Methods;Modeling;Mus;mutant;Myeloid Cells;neglect;Osmolar Concentration;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;Phagocytes;Play;Pneumonia;Positioning Attribute;Production;programs;Property;Proteins;Research;Research Personnel;Resource-limited setting;response;Role;Stimulator of Interferon Genes;Stimulus;Study models;subcutaneous;Temperature;Testing;Time;Tissues;transcriptome sequencing;transposon sequencing;Universities;uptake;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Leptospiral-Phagocyte Dynamics in Leptospirosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Although favorable responses have been attributed to recently approved targeted agents for the treatment of hematologic malignancies, such as acute myeloid leukemia (AML), the diversity of genetic mutations within blood cancers limits the curative potential of targeted monotherapies. However, hematologic malignancies are especially vulnerable to radiation, and thus genetically diverse sub-clones may all be eliminated by targeting radiation directly to the sites of disease through the powerful technology of radioimmunotherapy. This grant proposes to improve outcomes for AML by: 1) identifying synergistic combinations of radioimmunotherapy approaches with highly effective, but not yet curative, targeted agents; 2) correlating efficacy with the extent of DNA damage achieved by synergistic combinations; and 3) by comparing these radioimmunotherapy combinations as preparative chemotherapy prior to allogeneic bone marrow transplantation.

PI_NAMEs: OROZCO, JOHNNIE JOSE (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 90Y;Acute Myelocytic Leukemia;Allogeneic Bone Marrow Transplantation;Allogenic;Antibodies;antibody conjugate;Antibody Specificity;Apoptosis;Apoptotic;Astatine;BCL2 gene;Behavior Therapy;Bispecific Antibodies;Bone Marrow;Bone Marrow Transplantation;Cell Line;Cells;Cesium;chemotherapy;Chimerism;Chromosome abnormality;Clinical Research;clinical trial enrollment;Clinical Trials;Combination Drug Therapy;conditioning;curative treatments;Data;Disease;Disease remission;DNA Damage;DNA Repair;DNA Sequence Alteration;donor stem cell;dosimetry;Engraftment;ethnic minority population;Funding;Genetic Variation;Grant;Hematologic Neoplasms;Hematology;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;I131 isotope;Immunocompetent;improved;improved outcome;In Vitro;Infrastructure;inhibitor;interest;irradiation;Label;leukemia;leukemia treatment;Leukemic Cell;Lymphoma;Modeling;Monoclonal Antibodies;mouse model;multidisciplinary;Multiple Myeloma;Mus;new therapeutic target;Non-Hodgkin's Lymphoma;Normal tissue morphology;novel;Oral;Organ;Outcome;participant enrollment;Pathway interactions;patient subsets;Patients;Pharmacologic Substance;Poly(ADP-ribose) Polymerase Inhibitor;post-transplant;pre-clinical;Pre-Clinical Model;preclinical study;Prior Chemotherapy;Prior Therapy;PTPRC gene;Radiation;Radiation Dose Unit;Radiation therapy;Radioimmunoconjugate;Radioimmunotherapy;Radioisotopes;Radiolabeled;Regimen;Relapse;Reporting;Research Personnel;response;Site;small molecule;small molecule inhibitor;Spleen;Supportive care;Surface Antigens;synergism;Systemic disease;Systemic Therapy;targeted agent;targeted treatment;Technology;Tissues;Toxic effect;Translating;Transplantation;Treatment Efficacy;Treatment Failure;tumor;tumor eradication;United States National Institutes of Health;Whole-Body Irradiation;Xenograft procedure

PROJECT_TITLE: Combining Targeted RIT and Synergistic Novel Agents to Eradicate AML

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project narrative (Public health relevance statement) Mitochondria are indispensable organelles that generate energy and perform other vital functions for eukaryotic cells. Human health therefore depends on the proper function of mitochondria, and we are studying the processes that maintain mitochondrial function in cells. In the long-term, advances from these studies can be used to improve mitochondrial function and mitigate disease.

PI_NAMEs: CHAN, DAVID C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Actins;Apoptosis;Astrocytes;Biogenesis;biological adaptation to stress;Calcium;Cell Physiology;Cells;Cellular biology;Cellular Stress;Central Nervous System;Chromatin Remodeling Factor;Citric Acid Cycle;Coupled;Coupling;CRISPR interference;Cytoskeleton;Data;density;Disease;Ensure;Equilibrium;Eukaryotic Cell;Event;fatty acid metabolism;Future;Gene Expression;Generations;Genes;Health;Human;improved;in vivo;insight;Iron;Knowledge;Link;Lysosomes;Membrane Fusion;Mitochondria;Molecular;mouse genetics;Natural Immunity;Neurons;Oligodendroglia;Organelles;Oxidative Phosphorylation;Pathway interactions;Phenotype;Physiology;Play;Population;Process;programs;public health relevance;Research;Research Project Grants;response;Role;Signal Transduction;Sulfur;whole genome

PROJECT_TITLE: Homeostatic Mechanisms Regulating Mitochondrial Health


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative There is evidence that improving diversity in the surgical workforce offers an opportunity to improve the quality of care for underrepresented minority patients, as patients have improved outcomes, satisfaction, and compliance when cared for by a diverse group of physicians. Unfortunately, the current surgeon workforce does not parallel the general population’s race and gender composition; to address this disparity, we have developed a multi-organizational collaboration looking to define the landscape of diversity in surgery. Using a deviance approach and mixed methods, we will study programs that have been successful at retention and promotion of minority and women residents and faculty to define best practices and potential interventions.

PI_NAMEs: SOSA, JULIE ANN;YEO, HEATHER  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academia;Academic Medical Centers;Accreditation;Address;Administrator;Ally;American;Area;Asian;Association of American Medical Colleges;black men;Black Populations;Black race;care outcomes;career;Caring;Certification;Characteristics;Client satisfaction;Clinical Trials;cohort;Collaborations;Complex;COVID-19 pandemic;cultural competence;Data;Data Analyses;Disparity;disparity reduction;Drops;Enabling Factors;Enrollment;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;faculty support;Failure;Feedback;Female;Focus Groups;follow-up;Future;Gender;gender disparity;General Population;graduate medical education;Guidelines;high risk;Hispanic;Historically Black Colleges and Universities;improved;improved outcome;Individual;Infrastructure;Institution;Intervention;Interview;Latino;male;Measures;Medical;medical schools;medical specialties;Medical Students;Medicine;Mentorship;Methodology;Methods;mid-career faculty;Minority;minority patient;Murder;Nature;novel;Operative Surgical Procedures;Organizational Culture;Outcome;parity;Patient advocacy;patient advocacy group;Patient Care;patient population;Patient-Focused Outcomes;Patients;Perioperative;Physicians;Pilot Projects;Play;Population;Practice Guidelines;Process;professor;programs;Qualifying;Quality of Care;Race;racial disparity;racial population;Records;Research;Research Personnel;Residencies;Risk;Running;satisfaction;senior faculty;Sex Orientation;Societies;sociodemographic factors;sociodemographics;statistics;success;Surgeon;surgery outcome;surgical disparities;Surgical Specialties;Surveys;Testing;Training;Training Programs;treatment planning;Underrepresented Minority;underserved area;Uninsured;Universities;Woman;women faculty;women patients;Work

PROJECT_TITLE: Addressing Surgical Disparities at the Root; Working to improve diversity in the surgical workforce

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: PICARDEAU, MATHIEU  (contact)

PROJECT_TERMS: Acute;acute infection;Amphibia;Animal Model;Animals;Antigens;Attention;Bacteria;Biology;Birds;Classification;Classification Scheme;Clinical;Collaborations;Collection;comparative genomics;Complex;contaminated water;Data;Defense Mechanisms;Development;Diagnosis;Disease;Disease Marker;Dose;Environment;Epigenetic Process;Event;Evolution;Face;field study;gain of function;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Goals;Hamsters;host colonization;Host Defense Mechanism;Human;human pathogen;In Vitro;in vivo;Infection;insight;Knowledge;Laboratories;Leptospira;Leptospira interrogans;Leptospirosis;Libraries;Life;loss of function;Mammals;Modeling;Modification;Molecular;Mutagenesis;mutant;Mutation;neglect;novel strategies;Oxidative Stress;pathogen;Pathogenicity;Peroxides;Phenotype;Phylogenetic Analysis;Play;Predisposition;Process;programs;Rattus;Regulon;Reptiles;response;Role;Route;Sampling;Severity of illness;Small RNA;Soil;Stress;tool;transcriptome;transcriptome sequencing;transmission process;Untranslated RNA;Urine;Virulence;Virulence Factors;Virulent;Water;Work;Zoonoses

PROJECT_TITLE: Virulence and Adaptation to the Host Environment of Pathogenic Leptospira


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Nutrition;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research will provide novel insight into malfunction of energy producing pathways in pediatric genetic epilepsy and suggest innovative metabolic treatments for controlling pediatric seizures and behavioral impairment.

PI_NAMEs: BARABAN, SCOTT C;PATEL, MANISHA N (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: acquired epilepsy;Address;Adrenergic Agents;Age;Anxiety;Behavior;Behavioral;behavioral impairment;Bioenergetics;Biopsy;blood glucose regulation;Branched-Chain Amino Acids;Cell Respiration;Childhood;childhood epilepsy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Cytosol;Data;de novo mutation;Defect;Developmental Delay Disorders;disease phenotype;Down-Regulation;dravet syndrome;drug discovery;Embryo;Energy Metabolism;Enzymes;Epilepsy;Fishes;Gene Expression;Genes;Genetic;Gluconeogenesis;Glucose;glucose metabolism;Glycerol;Glycolysis;Guanosine Triphosphate;Human;Hypoglycemia;Impairment;inhibitor;innovation;insight;Investigation;ketogenic diet;knock-down;Laboratories;Larva;Life;Link;Mediating;Metabolic;Metabolism;Methodology;Mitochondria;model organism;Modeling;Mus;Muscle;mutant;novel;Outcome;Oxaloacetates;Oxygen Consumption;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Play;Pyruvate;Reporting;Research;Rest;Risk;Role;SCN1A protein;Seizures;Serotonin;Sleep disturbances;Sodium Channel;Source;Starvation;Steroids;sudden unexpected death in epilepsy;Testing;Therapeutic;Therapeutic Intervention;Time;Up-Regulation;virtual;voltage;Zebrafish

PROJECT_TITLE: Gluconeogenic control of Dravet Syndrome


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Rehabilitation;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Abuse of prescription opioids is a major health problem characterized by the persistence of opioid use despite negative consequences. Although opioid abuse is related to altered dopamine release in the mesolimbic and cortico-striatal system, the functional connectivity abnormalities within these systems in opioid users are not well understood. This research will use a novel method, concurrent TMS-fMRI, to examine the functional connectivity alterations between the mesolimbic and cortico-striatal system among opioid users and demonstrate the efficacy of rTMS in the treatment of opioid use.

PI_NAMEs: OH, HYUNTAEK  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Affect;Alcohols;Area;Behavior;Biological;Brain;Brain region;Capital;career;career development;Cessation of life;Clinical;clinical application;cognitive control;Corpus striatum structure;craving;Data;Data Analyses;Dependence;design;Development;Dopamine;Dorsal;Drug usage;evidence base;experience;experimental study;FDA approved;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Goals;Habenula;Health;Human;Impaired cognition;Individual;inpatient service;Intervention;Knowledge;Learning;Left;Maintenance;Maps;Measurement;Measures;Mental Depression;Mental Health;Methods;Motivation;multidisciplinary;neural circuit;Neurobiology;neurodevelopment;neuroimaging;Neurologic;Neurosciences;noninvasive brain stimulation;novel;Opiate Addiction;opioid abuse;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;Outcomes Research;Patients;Pattern;Persons;Physiologic pulse;pre-clinical;prescription opioid abuse;professor;Psychiatric Hospitals;psychiatric inpatient;Psychiatry;Punishment;Randomized;Randomized, Controlled Trials;Recovery;recruit;repetitive transcranial magnetic stimulation;Research;Research Personnel;response;Rest;Rewards;Scanning;screening;Signal Transduction;skill acquisition;skills;Smoking;Statistical Methods;substance use;System;tenure track;Testing;Therapeutic;Training;Transcranial magnetic stimulation;translational applications;Treatment Efficacy;United States;Withdrawal;Work

PROJECT_TITLE: Functional connectivity alterations among opioid users in treatment

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PI_NAMEs: DESAI, MICHAEL M (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Antibiotic Resistance;asexual;Bar Codes;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Compensation;Complex;Computing Methodologies;CRISPR/Cas technology;Data;Dimensions;Environment;Evolution;fitness;Future;Genetic;Genetic Epistasis;Genetic Variation;Goals;Health;Human;Immune;Individual;knockout gene;Laboratories;Ligands;Malignant Neoplasms;Maps;mathematical methods;mathematical model;Measurement;Measures;Methods;microbial;Mutation;Natural Selections;novel;Outcome;Partner in relationship;pathogen;Pattern;Phenotype;Play;pleiotropism;Population;Population Genetics;programs;Public Health;public health relevance;Quantitative Genetics;Quantitative Trait Loci;receptor;Research;response;Role;Saccharomycetales;statistics;Structure;Surveys;System;Testing;theories;Time;transposon sequencing;Variant;Work

PROJECT_TITLE: Microbial Adaptation and the Statistics of Epistasis and Pleiotropy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


PI_NAMEs: COBURN, JENIFER L (contact)

PROJECT_TERMS: Adherence;Adherens Junction;Adhesions;Affinity;Animal Model;Bacteria;Bacterial Adhesins;Bacterial Genes;Binding;Biological Markers;Blood Circulation;Blood specimen;cadherin 5;Cell Communication;Cell Culture Techniques;Cells;Clinical;Collaborations;cytokine;Data;Data Set;Development;Diagnostic;Disease;Endothelial Cells;Endothelium;Environment;experimental study;Family;gain of function;Gene Expression;Genome;Genomics;Hematogenous;Hemorrhage;Human;human disease;Immune response;improved;in vivo;Infection;Inflammatory;insight;interest;Invaded;knock-down;Knock-in;Leptospira;Leptospira interrogans;Leptospirosis;leucine-rich repeat protein;Mediating;medical schools;migration;Modeling;mouse model;Multiple Organ Failure;mutant;novel;pathogen;Pathogenicity;Patients;Phenotype;potential biomarker;Production;protein function;Proteins;Reaction;receptor;Receptor Cell;response;response biomarker;Role;Sampling;Severities;Statistical Data Interpretation;Testing;tissue tropism;transcriptome sequencing;Vascular Permeabilities;Virulence;Virulence Factors;Wisconsin;Work;Zoonoses

PROJECT_TITLE: Invasion Dynamics


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Pulmonary fibrosis is a devastating disease associated with debilitating shortness of breath and a rapid progression to death. Because current treatment options are limited, it is critical that new therapies are identified. We propose experiments to determine how lung epithelial cell injury/death, a common feature of fibrosis, drives lung fibrosis with the goal of identifying novel therapeutic targets.

PI_NAMEs: KIM, KEVIN KEEWOUN (contact);SISSON, THOMAS H

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Alveolar;alveolar epithelium;Alveolar fibrosis;Alveolar Macrophages;Animal Model;Apoptosis;Apoptotic;Attenuated;Automobile Driving;Bleomycin;Bone Marrow;Bone Marrow Transplantation;Catabolism;CCL2 gene;CD36 gene;cell injury;Cells;Cessation of life;chemokine;Chimera organism;Chronic;Cicatrix;Data;Defect;Development;Diagnosis;Disease;disease model;Disease Progression;Enzymes;Epithelial Cells;Epithelium;Etiology;Exhibits;experimental study;Exposure to;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Generations;Goals;Human;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;Ingestion;inhibitor;injured;Injury;interstitial;Knockout Mice;Knowledge;Ligands;Link;Lipids;Lung;lung injury;Macrophage;Macrophage Activation;Mediating;Medical;Modeling;monocyte;mouse model;Mus;new therapeutic target;novel;novel therapeutics;Null Lymphocytes;Organ;Organ failure;oxidation;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Phenotype;Phospholipase A2;phospholipase A2 inhibitor;Phospholipids;pneumocyte;Predisposition;Profibrotic signal;Publishing;Pulmonary Fibrosis;receptor;Recombinant Proteins;Recombinants;recruit;repaired;Reporting;Research Project Grants;response;Role;Sampling;Secondary to;Shortness of Breath;Signal Pathway;Signal Transduction;surfactant;Systemic disease;targeted treatment;Testing;Time;tissue injury;Transforming Growth Factor beta;Transgenic Mice;Translating;Transplantation Chimera;uptake

PROJECT_TITLE: Oxidized Phospholipids Derived from Apoptotic Pneumocytes Drives Macrophage Activation and Initiates Lung Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Prevention

PHR: PROJECT NARRATIVE Complex chronic conditions account for a large portion of disease, death, and disability in the US. However, progress in finding effective solutions to these health problems are thwarted by the lack of nurses with skills to address these complex problems in the context of the team scientific processes that will be necessary. The proposed project will contribute to the health of the Nation by supplying nurse-scientists who are prepared to become innovative and successful scientists who will leverage team science approaches to promote health for individuals with or at risk for complex chronic conditions.

PI_NAMEs: MCCULLAGH, MARJORIE E (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Health Promotion;innovation;Science

PROJECT_TITLE: Complexity: Innovations in Promoting Health through Team Science


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Neurosciences;Pain Research;Patient Safety;Pediatric;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE For the growing population of children with medical complexity, many medical decisions have no clear best treatment option; such decisions should be guided by individual patient preferences and values and clear communication of decision-related uncertainty through the use of shared decision making. This proposal develops a decision support tool for parents and providers of children with neuromuscular scoliosis who are deciding whether to undergo spinal fusion, a potentially life changing surgery but one that has significant complications. This work will serve as the foundation for using shared decision making to improve outcomes for children with medical complexity by supporting informed health care decisions and by using implementation science to develop scalable decision support tools that improve shared decision making.

PI_NAMEs: LIN, JODY  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adult;Agreement;Award;Benefits and Risks;Biometry;career development;Child;Childhood;Climacteric;Clinical;clinical decision support;clinical practice;Collaborations;Communication;Communication Methods;comorbidity;Consultations;Cost Effectiveness Analysis;Decision Making;Dedications;Deformity;design;Development;Disease;disorder control;effectiveness evaluation;effectiveness outcome;Elements;Equilibrium;Exercise;expectation;experience;experimental study;Face;Family;feasibility testing;Foundations;Future;Goals;Grant;Health;health communication;Health Services Research;Health system;Healthcare;Heterogeneity;high risk;Hospitalists;human centered design;Impaired cognition;implementation facilitators;implementation science;implementation strategy;improved;improved outcome;individual patient;innovation;Intervention;Knowledge;Lead;Leadership;Life;Medical;Mentors;Mobility decline;Modeling;Modification;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;Musculoskeletal;Neurologic;neuromuscular;Neuromuscular conditions;novel;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Measure;Pain;Pain management;Parents;Pathology;Patient Preferences;Patients;Physical therapy;Physicians;Pilot Projects;Population;preference;Process;programs;Provider;Proxy;Psychology;Randomized;Randomized, Controlled Trials;Research;Research Activity;Research Personnel;Research Training;respiratory health;Risk;satisfaction;Science;Scientist;scoliosis;shared decision making;skills;Spinal;Spinal Fusion;success;support tools;surgical risk;Testing;tool;Training;Training Activity;Training Programs;treatment risk;Uncertainty;Universities;Utah;Work;Wrestling

PROJECT_TITLE: Developing an Innovative Decision Support Tool for Pediatric Neuromuscular Scoliosis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


PHR: Project Narrative  This application requests funds to support the training of 8 graduate students per year in an interdisciplinary Pharmacological Sciences graduate program. Fifty-four training faculty from 16 departments provide a wealth of diverse research training opportunities for students. The goal is to produce broadly trained scientists who will contribute to the biomedical workforce, especially to the discovery, development and regulation of novel therapeutic agents that will improve healthcare in the United States and worldwide.

PI_NAMEs: HALL, RANDY A. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Graduate Training in the Pharmacological Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Precision Medicine

PROJECT_TERMS: 12 year old;accurate diagnosis;Acute;acute infection;Age;analytical method;Animals;Antibiotic Therapy;Antibiotics;Bacteria;biobank;Biological;Biological Markers;biomarker validation;Cessation of life;Clinical;Clinical Data;cohort;Collection;Communicable Diseases;comorbidity;cost;Culture Media;cytokine;Data;data integration;demographics;Dengue;Derivation procedure;detection method;Development;Diagnosis;Diagnostic;diagnostic development;diagnostic platform;Diagnostic tests;Disease;Disease Progression;Doctor of Philosophy;Early treatment;Ecology;Enrollment;Epidemiology;Etiology;Evaluation;experience;Fever;follow-up;Gene Expression;Geography;Goals;Hemorrhage;Human;Immune response;improved outcome;Infection;Infectious Agent;Leptospira;Leptospirosis;Life;Link;Location;Lung;Machine Learning;Metadata;Modality;Molecular;molecular marker;Morbidity - disease rate;mortality;multiple omics;Multiple Organ Failure;Nicaragua;novel;novel diagnostics;Occupational;Organ failure;participant enrollment;pathogen;Pathogen detection;Pathologic;Patients;Performance;Persons;Phase;predictive marker;Prognosis;prognostic;programs;prospective;Prospective Studies;protein expression;Proteomics;Recreation;recruit;Research;response biomarker;Rural;Sampling;Sepsis;Serology;Severities;Severity of illness;sex;Site;Specimen;Sri Lanka;Syndrome;synergism;systemic inflammatory response;Tanzania;targeted treatment;tool;Translating;Treatment outcome;Universities;Urine;Validation;Viral;Work

PROJECT_TITLE: Harnessing the Host Response to Leptosporisis for Diagnosis and Prognosis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences;Pediatric

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Adolescence is an understudied life stage during which profound brain remodeling and behavioral development can be influenced by early life environmental factors such as metals. We propose that exposure to a mixture of neuroactive metals in early life (age 0-2 years) impacts brain development manifesting as maladaptive trajectories of executive function, specifically involving attention and working memory.

PI_NAMEs: HORTON, MEGAN K (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 16 year old;Acceleration;Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;adolescent health;Adult;Age;Attention;Behavioral;behavioral phenotyping;Biological Markers;Birth;Brain;Brain region;brain remodeling;Childhood;Chromium;cohort;Communities;Complement;Complex Mixtures;computerized;Copper;Data;design;Development;Disease;early childhood;early life exposure;Enrollment;Environment;Environmental Health;Environmental Risk Factor;Epidemiology;executive function;Exposure to;fetal;Future;Geographic Locations;Grant;Health;improved;in utero;Individual;infancy;innovation;Intervention;Italy;Lead;Life;Life Cycle Stages;Link;Literature;Longitudinal cohort;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Manganese;Measures;Mediating;member;Metal exposure;Metals;Methods;Modality;Modeling;multimodality;neural circuit;neurobehavior;neurobehavioral;neurodevelopment;neuroimaging;neuroprotection;Neuropsychology;neurotoxic;Newborn Infant;novel;Outcome;Phenotype;Plants;postnatal;postnatal period;preadolescence;Predisposition;Pregnancy;prenatal;prevent;programs;prospective;Public Health;public health intervention;Research;Role;Short-Term Memory;Steel;Structure;Testing;theories;Time;timeline;tool;Tooth structure;transition to adulthood;Zinc

PROJECT_TITLE: Metal mixtures, exposure windows, and neurodevelopmental trajectories from adolescence to adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Knowledge about environmental epidemiology - the study of the determinants and distribution of environmental causes and contributions to disease in human populations - has grown exponentially. With major advances in methodology, exposure assessment tools, toxicology, and genomics, and the increasing appreciation for multidisciplinary expertise, the need for well-trained highly skilled researchers and clinicians in this area has never been greater. We propose, through the continuation of this training grant, to continue to provide high quality training in environmental epidemiology and related disciplines to educate the next generation of outstanding scholars and public health researchers in this vital field.

PI_NAMEs: LADEN, FRANCINE  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Training Program in Environmental Epidemiology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]