PHR: NARRATIVE – OVERALL The University of Michigan Vision Research Center provides state-of-the-art equipment and technical expertise and service for scientists at the University of Michigan to advance research programs into understanding the visual system and to develop novel therapies to treat blinding eye disease and improve the visual health of the country.

PI_NAMEs: ANTONETTI, DAVID  (contact)

PROJECT_TERMS: Acceleration;Animal Technicians;Animals;Basic Science;Biochemistry;Biometry;Clinical;Clinical Research;Collaborations;Complex;Core Grant;Country;data integrity;Dedications;design;design and construction;Developmental Biology;Disease;Electronics;Electrophysiology (science);Engineering;Environment;Equipment;Evaluation;eye center;Eye diseases;Fluorescence Microscopy;Fostering;Goals;Grant;Health;Human;Human Resources;Image;Image Analysis;Immunology;improved;innovation;instrument;instrumentation;interest;Laboratory Animals;Laboratory Technicians;Light;Mechanics;Michigan;Microscopy;Molecular Biology;Molecular Genetics;Morphology;Neurobiology;novel therapeutics;ocular imaging;Ophthalmology;Patients;prevent;Productivity;programs;repaired;Research;Research Personnel;Resources;Scientist;Services;skills;square foot;stem cell biology;Structure;Technical Expertise;tissue processing;Universities;Vision;vision development;Vision research;vision science;Visual;Visual System


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Understanding how serotonin neuron subtypes develop is of general interest as serotonin has wide-ranging modulatory effects on central neural circuitry and altered serotonergic gene expression, brought about by either genetic or early life environmental stressors, has been implicated in several neuropsychiatric diseases including depression, stress-related anxiety disorders, autism, OCD, and schizophrenia. The objective of the proposed research is to use single cell RNAseq and ATACseq to understanding spatiotemporal dynamics of 5- HT subtype development. These single cell genomics approaches will be used to investigate previously unaddressed fundamental questions about how continuously expressed neuronal transcription factors control 5-HT neuron subtype development, which may provide fundamental knowledge about underlying mechanisms of neurodevelopmental disorders that may result from altered development of specific neuron subtypes.

PI_NAMEs: DENERIS, EVAN S (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Anatomy;Antibodies;anxiety-related disorders;ATAC-seq;autism spectrum disorder;Binding Sites;Bioinformatics;Birth;Brain;Brothers;Cell Separation;Cells;Characteristics;ChIP-seq;Chromatin;Classification;Code;cofactor;Data;Data Set;Development;differential expression;Disease;Electrophysiology (science);Embryo;environmental stressor;Epitopes;experience;fetal;Gene Expression;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;genome sequencing;Genomic approach;genomic platform;Goals;Heterogeneity;Human;Intellectual functioning disability;interest;Knock-out;Knowledge;Life;Location;Mental Depression;Mental disorders;Methods;Molecular;Morphology;Mouse Strains;Mus;mutant;Mutation;neural circuit;Neurodevelopmental Disorder;neurogenetics;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;Orthologous Gene;Pathway interactions;Pattern;Phenotype;Population;postmitotic;postnatal;Process;programs;Regulation;Reporting;Research;reuptake;Sampling;Schizophrenia;Serotonergic System;Serotonin;single cell analysis;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Sorting;spatiotemporal;Stress;Testing;Time;Tomatoes;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;Transgenic Organisms;whole genome

PROJECT_TITLE: Gene regulatory mechanisms controlling development of serotonin neuron subtypes

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: RUCCI, MICHELE  (contact)

PROJECT_TERMS: 3D Print;adaptive optics;adaptive optics scanning laser ophthalmoscopy;analog;Anesthesia procedures;Animals;Anterior;awake;Biomechanics;Blood flow;Cells;Cephalic;Collaborations;Computer software;Computers;Conceptions;Core Grant;Cornea;cranium;Custom;design;detector;Development;Devices;digital;Electric Stimulation;Electrodes;Electronics;Engineering;Evaluation;experience;experimental study;Extramural Activities;Eye;fabrication;Faculty;Foundations;Funding;Goals;Image;Immune;Immunology;Injections;instrument;instrumentation;Laboratories;Lasers;mechanical device;Mechanics;member;Microscope;Microscopy;multi-electrode arrays;Mus;neurophysiology;new technology;novel;Optical Coherence Tomography;Optics;Physiologic Monitoring;Positioning Attribute;Primates;Productivity;Research;Research Personnel;Research Project Grants;Resolution;retinal imaging;Scanning;sensor;sight restoration;skills;Speed;System;Technology;Translating;ultra high resolution;Ultrasonic Transducer;virtual reality;virtual reality environment;Vision research;vision science;visual stimulus

PROJECT_TITLE: INSTRUMENTATION CORE


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PROJECT_TERMS: Address;Administrator;Area;Award;Blindness;Blood Vessels;Budgets;Client satisfaction;Collaborations;Communication;Communities;Country;Data;design;Diabetic Retinopathy;Doctor of Philosophy;Ensure;Environment;Equity;Expenditure;eye center;Eye diseases;fabrication;Funding;Grant;Health;Image;improved;Individual;instrument;instrumentation;Laboratories;meetings;Methods;Michigan;Mission;Molecular Biology;Morphology;novel;novel therapeutic intervention;novel therapeutics;operation;Ophthalmology;Pathology;prevent;professor;programs;Progress Reports;Questionnaire Designs;Reporting;Research;Research Personnel;Resource Allocation;Resources;restoration;Retina;Role;Running;Scientist;Services;Signal Pathway;Statistical Data Interpretation;stem cell biology;Supervision;Surveys;Time;United States National Institutes of Health;Universities;Vascular Permeabilities;Vision;Vision research;vision science;Visual;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: WOODWARD, MARIA ANNEKE (contact)

PROJECT_TERMS: Acceleration;Address;Algorithms;Bioinformatics;Clinical Investigator;Clinical Sciences;cluster computing;Code;Collaborations;Communities;Consult;Critiques;Data;Data Analytics;data integrity;data management;data quality;data reuse;Data Science;data science resource;Data Set;Data Storage and Retrieval;Dedications;Development;Effectiveness;Ensure;Eye;eye center;Faculty;FAIR principles;Funding;Goals;Grant;Health Services;High Performance Computing;innovation;interoperability;Investigation;K-Series Research Career Programs;Life Cycle Stages;Methodology;Michigan;Modeling;Monitor;multidisciplinary;novel;open source;Production;programs;Publishing;Reproducibility;Research;Research Personnel;Resources;Schedule;Scientist;Structure;Time;tool;Training;Translational Research;United States National Institutes of Health;Universities;virtual;Vision;Vision research;Work

PROJECT_TITLE: Data Integrity Core


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Alzheimer’s disease is a devastating dementia with no cure. Our work will investigate why some regions of the brain are susceptible to degeneration in Alzheimer’s disease models, and whether the connections between these regions are key for the specificity of brain cell loss.

PI_NAMEs: CHUNG, KWANGHUN  (contact);TSAI, LI-HUEI

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Area;Atlases;Axon;Brain;brain cell;Brain imaging;Brain Mapping;Brain region;Brain Stem;cell type;Cells;Characteristics;connectome;Data;Data Set;Dementia;density;Disease;Disease Progression;entorhinal cortex;experimental study;Fiber;Genetic;Genotype;high resolution imaging;Hippocampus;Human;improved;Knock-in;Knock-in Mouse;Knowledge;Label;Lateral;Light;Link;locus ceruleus structure;Maps;Medial;Methods;Microscopy;middle age;Modeling;Molecular;Molecular Biology;molecular marker;Molecular Profiling;mouse model;Mus;neural;Neurons;Norepinephrine;Occipital lobe;Output;Pathology;Pathway interactions;Pattern;Population;Predisposition;Prefrontal Cortex;presynaptic;Property;rabies viral tracing;Rabies virus;red fluorescent protein;Research;Resolution;response;Signal Transduction;single nucleus RNA-sequencing;Source;spatiotemporal;Specificity;Synapses;Synaptophysin;System;tau Proteins;Time;Tissue Preservation;Tissues;transcriptomics;Viral;Virus;Work

PROJECT_TITLE: Mapping the vulnerable locus coeruleus pathways in aging and AD


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Anatomy;Animal Housing;Animal Model;Animals;Anterior;Binding;Blindness;Choroidal Neovascularization;Collaborations;Computer software;Dark Adaptation;Darkness;design;efficacy evaluation;Electrophysiology (science);Electroretinography;Environment;Equipment;experience;Eye;Eye diseases;fluorescence imaging;Fostering;Funding;Gene Modified;germ free condition;Housing;Human Resources;Image;Imaging Device;imaging system;in vivo;Individual;innovation;instrument;Investigation;Laboratories;Laboratory Research;Lasers;Light;Longitudinal Studies;Maintenance;Measurement;Measures;Meridians;Michigan;Morphology;novel;novel therapeutics;Optical Coherence Tomography;Phenotype;Pilot Projects;pressure;prevent;Procedures;Research;Research Personnel;response;Retina;retinal imaging;Rodent;Rodent Model;Schedule;Scientist;slit lamp imaging;square foot;Structure;System;Testing;Therapeutic Intervention;tool;Training;Universities;Vision;Vision research;Visual;Visual System

PROJECT_TITLE: Functional Assessment Core


PI_NAMEs: WEILAND, JAMES D. (contact)

PROJECT_TITLE: Instrument & Electronics Services Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: ABCOUWER, STEVEN F (contact)

PROJECT_TERMS: Back;Cell Culture Techniques;Cell Reprogramming;Cells;Cellular biology;Centrifugation;cost effective;Dedications;Disease;DNA;DNA purification;Drops;Emergency Situation;Ensure;Equipment;equipment training;experimental study;Floor;Flow Cytometry;Funding;Genes;genome editing;Health;Human;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;innovation;Instruction;instrument;instrumentation;interest;Laboratories;laboratory equipment;Maintenance;Michigan;Modeling;Modernization;Molecular;Molecular Biology;nano;Neurons;Organoids;protein purification;Reader;Regenerative Medicine;Regenerative research;replacement tissue;Research;Research Personnel;Resources;Retina;RNA;RNA purification;Sampling;Scientist;Spectrophotometry;square foot;stem cells;Surveys;System;Temperature;Time;Tissues;Training;Transgenic Animals;Ultracentrifugation;Universities;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Molecular Biology Core


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The methyl-CpG binding protein 2 (MeCP2) is a highly abundant chromatin-binding protein, which if mutated causes Rett syndrome, a severe neurological disorder with no approved therapies that directly address the underlying defects of MeCP2 loss of function. One primary contributor to the lack of MeCP2-targeted interventions is an inadequate understanding of how MeCP2 reads methylated DNA within hierarchically organized chromosomes. This proposal will use single-molecule visualization and structural biology technologies to investigate how MeCP2 biophysically navigates the chromatin landscape to reach its canonical methyl-DNA substrate at unprecedented spatial and temporal resolution.

PI_NAMEs: CHUA, GABRIELLA N. L. (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Affect;Affinity;Behavior;Binding;Binding Proteins;biophysical properties;Biophysics;Cell Nucleus;Central Nervous System;Chromatin;chromatin protein;Chromosome Structures;Collaborations;Color;Complex;crosslink;Cryoelectron Microscopy;Data;Defect;density;Diffusion;Disease;DNA;DNA Methylation;DNA Packaging;Environment;Exhibits;Female;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Gene Expression;Genes;Heterogeneity;Histones;Human;improved;Individual;insight;Intervention;Investigation;Kinetics;Linker DNA;loss of function;loss of function mutation;Maps;Mass Spectrum Analysis;Methods;Methyl-CpG-Binding Protein 2;Methylation;Molecular Conformation;Motion;motor regression;Mutate;Mutation;Nervous System Disorder;Neurons;novel;Nucleosomes;optic trap;optical traps;particle;Pattern;Post-Translational Protein Processing;preference;Preparation;protein complex;protein oligomer;Proteins;Reader;real-time images;Reporting;Resolution;Rett Syndrome;Sampling;single molecule;Site;Specificity;Stochastic Processes;structural biology;Structure;Technology;temporal measurement;Testing;Time;Training;Visualization

PROJECT_TITLE: Single-molecule Investigation of the Interaction Between MeCP2 and Chromatin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HITCHCOCK, PETER F (contact)

PROJECT_TERMS: Anatomy;Cellular biology;Computer software;Computer Workstations;Confocal Microscopy;cryostat;Dedications;DNA;Electron Microscopy;Ensure;Environment;Equipment;Funding;Human Resources;Image;Image Analysis;image processing;imaging software;Imaging Techniques;Immunohistochemistry;In Situ Hybridization;instrumentation;Lasers;light microscopy;light transmission;Maintenance;Methods;Michigan;Microdissection;Microscope;microscopic imaging;Microtome - medical device;Morphology;Ophthalmology;Paraffin;Persons;Pilot Projects;preservation;Process;programs;Proteins;Protocols documentation;Research;Research Activity;Research Personnel;RNA;Running;Services;square foot;System;Technical Expertise;Tissue Fixation;tissue fixing;Tissues;tool;Training;Transmission Electron Microscopy;Universities;Vision research

PROJECT_TITLE: Morphology and Imaging Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PATHOLOGY

PHR: Project Narrative We propose to develop small molecule inhibitors blocking activity of PRC1 E3 ubiquitin ligase in leukemia. PRC1 blocks differentiation of leukemic cells and this research may yield valuable chemical probes for stem cell research and new anti-cancer agents.

PI_NAMEs: CIERPICKI, TOMASZ  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acute leukemia;acute leukemia cell;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affinity;analog;Animal Model;anti-cancer therapeutic;antileukemic agent;Binding;Biology;Blood Cells;BMI1 gene;Bone Marrow Cells;cell growth;Cell Line;Cells;Chemicals;chemotherapy;Chromatin;clinical application;Complex;Deposition;design;Development;Disease;Drug Kinetics;efficacy study;Epigenetic Process;Generations;Goals;Hematopoiesis;Histone H2A;HOXA9 gene;Hydrolysis;improved;in vivo;inhibitor;innovation;interdisciplinary approach;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;Maintenance;Modeling;Molecular Abnormality;Monoubiquitination;mouse model;Mus;Names;novel;novel anticancer drug;novel strategies;novel therapeutic intervention;Nucleosomes;Oncogenes;Outcome;overexpression;paralogous gene;patient derived xenograft model;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;PRC1 Protein;Prodrugs;Property;Proteins;Recurrence;Research;Resistance;Sampling;screening;self-renewal;small molecule;small molecule inhibitor;Solubility;Stem Cell Research;stem cells;structural biology;Structure;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Toxic effect;ubiquitin-protein ligase;Ubiquitination;Undifferentiated;Work;Xenograft Model

PROJECT_TITLE: Targeting PRC1 in leukemia

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: KANAYA, ALKA M.;SARKAR, URMIMALA  (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Area;Behavioral;Biometry;career;career development;Clinical;Clinical Informatics;Clinical Medicine;clinical practice;Clinical Research;Collaborations;complex data;Consultations;Data Science;Data Set;Dentistry;Development;Discipline;Discipline of Nursing;Education;Educational workshop;Elements;Epidemiology;Evolution;experience;Faculty;Fostering;Funding;Goals;Grant;Health Care Research;Health Occupations;health science research;Health Services Research;implementation science;improved;Individual;Informatics;insight;Institution;Knowledge;Leadership;life span;matriculation;medical schools;member;Mentors;Mentorship;Methodology;multidisciplinary;Pharmacy facility;Policies;population health;Positioning Attribute;Potassium;Program Development;programs;Public Health;Records;Research;Research Project Grants;Resources;Scholars Program;Schools;Science;skills;Special Population;Training;Training Programs;Translating;translational pipeline;Translational Research;Translations;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

ORG_CITY: TYLER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: Narrative Respiratory viral pathogens, such as SARS-CoV-2 and RSV, can cause deadly infections in human lungs and have exerted a tremendous public health burden. The proposed program of research focuses on the viral membrane fusion mechanism of SARS-CoV-2 and RSV, a process that is a prerequisite for a virus to enter host cells. The proposed studies will employ complementary/synergetic biophysical and biochemical tools to elucidate molecular mechanisms of the fusion process, guiding the design of future vaccines and therapeutics that target virus entry.

PI_NAMEs: LU, MAOLIN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Antibodies;biochemical tools;biophysical tools;Cell fusion;Cells;Chimeric Proteins;Comparative Study;conformational conversion;Deceleration;design;emerging virus;Event;Evolution;experience;Exposure to;Fluorescence Resonance Energy Transfer;Foundations;Frequencies;Future;Glycoproteins;Goals;HIV-1;Human;Immune response;Immune Targeting;Individual;Infection;insight;interest;Intervention;Kinetics;Knowledge;Lung;Mediating;Membrane Fusion;Mission;Modeling;Molecular;Molecular Conformation;National Institute of General Medical Sciences;pathogenic virus;prevent;Process;programs;Proteins;Public Health;receptor;Research;Research Personnel;respiratory;Respiratory syncytial virus;respiratory virus;Role;SARS coronavirus;SARS-CoV-2 spike protein;single molecule;Surface;Technology;therapeutic target;Time;tool;trait;vaccine candidate;vaccine development;Vaccines;Viral;Virus;Visualization

PROJECT_TITLE: The role of conformational dynamics of enveloped virus spike proteins in cell entry


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Of the millions of people who survive COVID-19, many will be affected by long-term neurologic symptoms. This study will evaluate long-term Neuropsychiatric Symptoms (NPS) and identify sex specific inflammatory profiles that contribute to this pathophysiology. Investigation of the chronic consequences of the disease is necessary as this pandemic will have consequences on public health and the economy for years to come.

PI_NAMEs: LIU, FUDONG ;MCCULLOUGH, LOUISE D. (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: 2019-nCoV;Acute;Acute Brain Injuries;acute COVID-19;Acute Disease;acute infection;Affect;Age;Antigens;Anxiety;B-Lymphocytes;biobank;bioinformatics tool;Blood;Brain;Brain Injuries;Cardiology;Cells;Chronic;Clinic;Clinical;cognitive function;Control Groups;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 survivors;cytokine;cytokine release syndrome;Data;Development;Disease;Disease Progression;Disproportionately impacts women;Drowsiness;Encephalitis;Endothelium;Enrollment;Event;experience;Fatigue;Flow Cytometry;follow-up;Functional disorder;functional status;Health;Hospitalization;hospitalization rates;Hospitals;Immune;immune activation;Immune response;Incidence;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Injury;Innate Immune Response;Internal Medicine;Investigation;Length of Stay;Leukocytes;Link;Literature;Long COVID;long-term sequelae;Longitudinal Studies;longitudinal, prospective study;Measures;Mechanical ventilation;men;Mental Depression;Modeling;monocyte;mortality;mortality risk;Neurologic;Neurologic Symptoms;Neurological outcome;Neuron-Specific Enolase;Neuronal Injury;neuropsychiatric symptom;neutrophil;Outcome;Pain;pandemic disease;Pathway interactions;Patients;Peripheral;Persons;Population;post SARS-CoV-2 infection;Post-Traumatic Stress Disorders;predictive modeling;Prevalence;prospective;Public Health;Reaction;Reporting;Research;response;Risk;Sampling;SARS-CoV-2 infection;Seizures;Serum;Serum Markers;sex;Sex Differences;Stroke;Survivors;Symptoms;systemic inflammatory response;T-Lymphocyte;Time;vaccine access;Virus;Woman

PROJECT_TITLE: Sex specific immune response to SARS-CoV-2 leads to chronic neurologic symptoms


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project narrative: The stratified epithelium is the most complex epithelial architecture among living systems and is most often subject to wounding and damage. Regeneration in this complex tissue requires multifaceted synchronization of several epithelial cell lineages and local tissue immune cells. My studies aim to functionally understand the epigenetic factors and pathways that regulate full tissue restoration in the stratified mammalian epithelium.

PI_NAMEs: WOAPPI, YVON  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Architecture;Biological Assay;Biological Models;career;career development;Cell Lineage;cell type;Cells;Complex;Cutaneous;Data Analyses;design;Development Plans;Dissection;diversity and inclusion;Dorsal;Dropout;Environment;Epidermis;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;experience;experimental study;Fibrosis;gene editing technology;Genes;Growth;Guide RNA;Harvest;Health;Human;human disease;Immune;Immune response;Immune System Diseases;Immunity;Immunocompetent;Immunohistochemistry;Immunology;Impairment;in vivo;injured;Injury;Intervention;intraepithelial;Keratin;keratinocyte;Knowledge;Laboratories;laboratory experience;Lead;Lung Diseases;Malignant Neoplasms;Mediating;Mediator;medical schools;Mentors;Mentorship;Molecular;Mucous Membrane;Mus;Natural regeneration;next generation sequencing;novel;Organism;Pathway interactions;pharmacologic;Phase;Population;post-doctoral training;Postdoctoral Fellow;Process;progenitor;programs;reconstruction;recruit;regenerative;regenerative cell;regenerative healing;Regenerative response;regenerative tissue;repaired;Research;Resolution;response;response to injury;restoration;Role;Science;Shapes;Signal Transduction;Site;skills;Skin;spheroids;Stains;Stratified Epithelium;Stress;T-Lymphocyte;Techniques;Therapeutic;Thick;Time;tissue regeneration;tissue stem cells;Tissues;Tongue;tool;Training;Work;wound;wound healing

PROJECT_TITLE: Delineating epigenetic coordination of regenerative cell plasticity


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Neurodegenerative

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Nearly all organisms require iron for growth and survival, and the few that do not require iron depend on manganese instead. Mismanagement of cellular concentrations of these metals has been implicated in a variety of human pathologies, from bacterial infections to neurodegenerative disease. This research proposal seeks to develop selective fluorescent sensors for iron and manganese in order to probe mechanisms of metal regulation in bacteria and in mammalian cells, with the goal of uncovering new and potentially unique avenues for therapeutic intervention in these diseases.

PI_NAMEs: COTRUVO, JOSEPH ALFRED (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Bacteria;Bacterial Infections;Binding;Biochemical;biological systems;Biology;Calcium;Cells;Chemistry;Complex;design;Disease;Enzymes;Eukaryotic Cell;Goals;Growth;Homeostasis;Human;human disease;Human Pathology;insight;Invaded;Ions;Iron;Iron Overload;Mammalian Cell;Manganese;Metals;Nature;Nerve Degeneration;Neurodegenerative Disorders;novel;novel strategies;nucleic acid binding protein;Nucleic Acids;Organism;pathogen;pathogenic bacteria;programs;Protein Export Pathway;protein transport;Proteins;rational design;Reaction;Regulation;Reporting;Research Proposals;RNA;sensor;small molecule;System;Therapeutic Intervention;tool;trafficking;uptake;Virulence;Yeasts;Zinc

PROJECT_TITLE: New tools to probe iron and manganese homeostasis in bacterial and eukaryotic cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Stress is known to be one of the primary triggers for HSV recurrent disease, although surprisingly little is known about how it does so. Although most studies have focused on viral latency in sensory neurons, HSV also establishes latency in autonomic neurons, which are highly responsive to hormones and likely contribute to differential pathogenesis of HSV1 and HSV2. Results from this proposal will identify how stress hormones, a known trigger for HSV recurrent disease, regulate HSV1 and HSV2 infections in autonomic and sensory neurons, and challenge the paradigm of HSV reactivation by demonstrating that autonomic neurons are an important source of HSV recurrent disease.

PI_NAMEs: BERTKE, ANDREA S (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute Disease;Adrenergic Receptor;Adult;Afferent Neurons;Animal Model;Anti-viral Agents;antiviral drug development;Autonomic nervous system;Autonomic Pathways;Blindness;Cavia;Chromatin;Corticosterone;CREB1 gene;Cyclic AMP;Data;Development;Encephalitis;Epinephrine;Event;experimental study;Face;Frequencies;Genitalia;Glucocorticoid Receptor;Goals;GTP-Binding Protein alpha Subunits;Herpesvirus 1;hormone regulation;Hormones;Human Herpesvirus 2;human model;Hydrocortisone;in vivo;Infection;innovation;Interferons;Life;Maintenance;MAPK8 gene;Mediating;Meningitis;Mineralocorticoid Receptor;Modeling;Neurons;Organ;Pathogenesis;Pathway interactions;Pattern;Pelvis;prevent;Process;receptor;Recurrence;Recurrent disease;Research;response;Rodent;Sensory;Severities;Signal Pathway;Signaling Protein;Simplexvirus;skin lesion;Source;Spinal Ganglia;Stimulus;Stress;Structure of trigeminal ganglion;Symptoms;Transcription Initiation;transmission process;Trigeminal System;viral DNA;Virus;Virus Activation;Virus Diseases;Virus Latency;VP 16;Work

PROJECT_TITLE: Stress Hormone Regulation of HSV1 and HSV2 in Autonomic and Sensory Neurons

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pain Research;Wound Healing and Care

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative The corneal epithelium supports and protects branches of the trigeminal nerve that provide sensation to the cornea. Dry eye and corneal abrasion disrupt the corneal barrier, cause degeneration of cornea nerves, and renders them more sensitive to environmental stimuli that may be perceived as discomfort and pain. The overall goal of this proposal is to determine the molecular changes in the corneal and nerve cells that are triggered by corneal barrier disruption and that cause corneal nerve degeneration and pain.

PI_NAMEs: CHEN, RUI ;DE PAIVA, CINTIA S.;PFLUGFELDER, STEPHEN C (contact);STEPP, MARY ANN

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Apical;Atlases;Axon;Basement membrane;Benchmarking;Biological Assay;Blinking;Brain Stem;Cell membrane;Cells;Chemicals;chemokine;Chromatin;Clinical;Communication;Complement;Complex;Cornea;Corneal Abrasion;Corneal Diseases;corneal epithelium;Cues;CXCL1 gene;CXCL10 gene;cytokine;Data;Debridement;density;Desiccation;Disease;environmental stressor;epigenetic profiling;Epithelial Cells;epithelial injury;epithelial wound;Epithelium;Esthesia;Event;experimental study;Eye;eye dryness;Film;Ganglia;ganglion cell;Gelatinase B;Gene Activation;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Health;Homeostasis;Immune;In Situ Hybridization;Injury;intraepithelial;irritation;Knock-out;Measures;Mechanics;microbial;Molecular;Morphology;Nerve;Nerve Degeneration;Nerve Pain;nerve supply;neural;neural circuit;Neuroglia;neuronal cell body;Neurons;Neuropeptides;neurosensory;Nociceptors;ocular pain;ocular surface;Optic Nerve;P2X-receptor;Pain;Pathologic;Pathology;Peptide Hydrolases;Peptides;Peripheral;preservation;Process;Production;Proliferating;Protein Family;Radial;receptor;recruit;response;RNA;Schwann Cells;Sclera;Sensory;Signal Transduction;Sodium Channel;Stimulus;Stress;Structure of trigeminal ganglion;Surface;Synapses;Thinness;Tight Junctions;Time;Tissues;transcriptomics;Trauma;Travel;Trigeminal nerve structure;Trigeminal System;Vanilloid;voltage;wound healing

PROJECT_TITLE: Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuit


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Prevention;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because OSA is a major health concern that is inadequately treated with existing therapies. The NHLBI 2011 Sleep Disorders Research Plan states that “studies are needed to identify clinically meaningful subtypes [of OSA], and algorithms informing the selection of optimal therapeutic strategies.” The proposed research directly addresses this important component of the NIH's mis- sion.

PI_NAMEs: WELLMAN, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Acoustics;Address;Adherence;adherence rate;Algorithms;base;Clinical;clinical practice;Continuous Positive Airway Pressure;cost;Data;Data Collection;Data Set;Devices;Disease;Drug usage;Early identification;effective therapy;Endoscopy;Epiglottis structure;experimental study;Explosion;Goals;Grant;Health;Home;Home environment;Hypoglossal nerve structure;improved;Individual;Label;Lateral;Literature;Mandibular Advancement;Measurement;Measures;Methods;Mission;National Heart, Lung, and Blood Institute;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Oropharyngeal;Otolaryngologist;Outcome;Patient Selection;Patients;Persons;Pharmaceutical Preparations;Pharyngeal structure;predictive modeling;Procedures;Progress Reports;Public Health;public repository;Reproducibility;Research;Shapes;Signal Transduction;Site;Sleep;Sleep Disorders;Snoring;sound;Structure;Testing;Therapeutic;tongue root;United States National Institutes of Health;Work

PROJECT_TITLE: Determination of the site of pharyngeal collapse in Obstructive Sleep Apnea patients from snoring sounds

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE With technological advancements in healthcare data capture, ﬁt-for-purpose real-world data (RWD) have now been used as external controls to improve the evaluation of safety and efﬁcacy in clinical trials, but such use of external controls is inevitably subject to potential confounding or hidden biases. We will develop a novel sensitivity analysis framework for the use of hybrid external controls to assess the impact of hidden biases, as well as robust and efﬁcient analysis methods that selectively borrow and adjust for data discrepancies to mitigate the impact of hidden biases. User-friendly software packages, statistical analysis plan templates to guide the proposed methods, and applications and case studies using completed clinical trials and RWD will be disseminated to the scientiﬁc community, with the ultimate goal of facilitating a more robust use of real-world evidence in regulatory decision-making.

PI_NAMEs: WANG, XIAOFEI  (contact);YANG, SHU

PROGRAM_OFFICER_NAME: LAUDA, MARK

PROJECT_TITLE: Methods to improve efficiency and robustness of clinical trials using information from real-world data with hidden bias


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: ORTHOPEDICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Neuromodulators such as serotonin and neuropeptides are critical for the function of complex neural circuits, and defective neuromodulator signaling is linked to a host of neurological and psychiatric disorders e.g. depression and affective disorders, schizophrenia, addiction, and Parkinson's disease. We use a powerful experimental model, the nematode C. elegans, to determine molecular mechanisms required for the development and in vivo function of neuromodulatory systems. Mechanisms we find through our studies require genes that are conserved between invertebrates and humans, and discovery of these mechanisms offers new opportunities to understand how neuromodulator signaling controls behavior and to imagine new treatments for psychiatric and neurological diseases caused by defective neuromodulation.

PI_NAMEs: RINGSTAD, NIELS  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: addiction;Affect;Animal Behavior;Animals;Behavior;Behavior Control;behavioral study;Biochemical;Brain;Caenorhabditis elegans;Carbon Dioxide;Clinical;Complex;Development;drug of abuse;Endowment;Experimental Models;gene conservation;gene discovery;genetic analysis;Genetic Screening;Genetic study;Goals;Hermaphroditism;host-microbe interactions;Human;in vivo;insulin signaling;interest;Invertebrates;Link;Mental Depression;Mental disorders;Microbe;microbial;Modeling;Molecular;Molecular Genetics;Mood Disorders;Motor;Nematoda;Nervous System;Nervous System Disorder;neural circuit;Neurobiology;Neuromodulator;neuronal excitability;Neurons;Neuropeptides;neuroregulation;Parkinson Disease;pathogen;programs;Psychiatric therapeutic procedure;reproductive;Reproductive Behavior;Respiration;Schizophrenia;Sensory;Serotonin;Serotonin Agonists;Signal Pathway;Signal Transduction;Stereotyping;System;Therapeutic;Toll-like receptors;transcription factor

PROJECT_TITLE: Molecular genetics of sensory modulation of motor programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Real-world clinical data hold tremendous potential to advance our understanding on the efficacy and safety of therapeutic interventions in broader populations, including disease modifying therapies for chronic diseases. However, these data remain underutilized due to methodological constraints and the inability to efficiently link and integrate data sources across study types and healthcare settings. We develop statistical approaches to enable use of real-world clinical data to define treatment responses in large and heterogeneous patient populations and inform product labeling for specific indications and patient groups.

PI_NAMEs: BOURGEOIS, FLORENCE  (contact);CAI, TIANXI

PROJECT_TITLE: Generating Reproducible Real-World Evidence with Multi-Source Data to Capture Unstructured Clinical Endpoints for Chronic Diseases


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Public Health Significance Relapse during recovery from alcohol and drugs is a common occurrence that undermines the improvements individuals make in multiple areas. Persons who relapse are prone to continue using substances and suffer additional consequences, such as psychiatric, legal, medical, and work problems. Although peer helping has been shown to have beneficial effects on alcohol outcomes, very few studies have examined the relative effects of giving and receiving different types of help (e.g., instrumental versus emotional) from different sources (e.g., recovering peers, family, and friends). The proposed study will examine the effects of helping behaviors among a sample of persons residing in peer operated sober living recovery houses (SLHs). Analyses will show the types of helping most strongly associated with sustained recovery and the pathways by which it operates.

PI_NAMEs: POLCIN, DOUGLAS L (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;acute care;Affect;Age;alcohol abstinence;Alcohol abuse;alcohol use disorder;Alcohols;Area;Characteristics;Coping Skills;Data;Development;drinking;Emotional;enhancing factor;Environment;experience;Family;Feedback;Focus Groups;Friends;Gender;Helping Behavior;Home;Household;improved;inclusion criteria;Individual;Inpatients;Intervention;Interview;Legal;Length;Length of Stay;Literature;Longitudinal Studies;Measures;Medical;men;Modeling;Neighborhoods;novel;Outcome;outcome prediction;outpatient programs;parent grant;Pathway interactions;peer;peer support;Persons;Pharmaceutical Preparations;primary outcome;Procedures;programs;Provider;Public Health;Race;randomized, clinical trials;rapid growth;Recovery;recovery house;recruit;Relapse;relapse prediction;Research;residence;Sampling;secondary outcome;self esteem;Services;Severities;Site;Social Environment;social model;Social Network;Socioeconomic Status;Source;substance use;sustained recovery;Testing;Therapeutic;Time;treatment services;Woman;Work

PROJECT_TITLE: Peer Helping, Retention, and Relapse in Sober Living Houses

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Stem cell therapy is being explored to recover the injured myocardium. Cardiac progenitor cells derived from neonatal tissue may have the greatest potential but the underlying mechanism of action is unknown. We are exploring the mechanism of how exosomes, the functional unit of cardiac progenitor cells, recovers the injured myocardium and how to detect exosomes in the serum to potentially create a potent, next generation stem cell therapeutic. In addition, the detection of plasma exosomes derived from the stem cell treatment provides an a noninvasive window into the conditional state of the transplanted cells.

PI_NAMEs: SCHUMACKER, PAUL T (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Activities of Daily Living;Acute;Adult;Affect;Age;Allogenic;angiogenesis;Animal Model;Animals;Apoptosis;Biological Assay;Biological Markers;Cardiac;Cardiac Myocytes;Cell Therapy;Cell Transplantation;cell type;Cells;Characteristics;Chronic;Clinical;Clinical Trials;Computer Analysis;Computer Models;Congenital Heart Defects;Coupled;Data;Detection;Diagnosis;effective therapy;Europe;exosome;Family suidae;Fibrosis;Funding;Gender;Genes;Head;head-to-head comparison;heart function;Heart Injuries;Heart Transplantation;heat-shock factor 1;HLA-A gene;Human;Human Resources;Hypertrophy;immunoregulation;improved;In Vitro;in vivo;Infarction;Inflammation;Inflammatory;injured;injury and repair;Least-Squares Analysis;Left Ventricular Remodeling;liquid biopsy;Measures;Methodology;Microarray Analysis;MicroRNAs;Modeling;Molecular;Monitor;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardium;Neonatal;neonatal human;next generation;non-invasive monitor;novel;overexpression;Parents;Pathway interactions;Patients;Phase;phase III trial;Plasma;Postoperative Period;pre-clinical;predict clinical outcome;Preparation;prevent;Principal Component Analysis;Process;progenitor;PTK2 gene;Publishing;Rattus;Recovery;regenerative;Regression Analysis;repaired;Reporting;response;RNA Sequences;Rodent;Rodent Model;Role;Serum;stem cell differentiation;stem cell exosomes;stem cell therapy;Stem cell transplant;stem cells;success;Surface;Systems Biology;Techniques;Testing;therapeutic miRNA;therapeutic RNA;Time;Tissues;transcriptome sequencing;Transplantation;Treatment Efficacy;Ventricular Remodeling;Work;wound response

PROJECT_TITLE: Mechanism of transplanted neonatal cardiac progenitor cells to repair ischemic myocardium

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Frontal lobe epilepsy is the second most common form of epilepsy, and seizures associated with this epilepsy are dangerous. We propose to map the neuronal circuits active during frontal lobe seizures with unprecedented spatial and temporal resolution. These studies will open novel targets for therapy by neuromodulation, resection, or drug treatment.

PI_NAMEs: KAPUR, JAIDEEP  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 3-Dimensional;Acute;Anatomical Sciences;Anatomy;antagonist;Anterior;Anticonvulsants;Axon;Basal Ganglia;Bilateral;Brain;BRAIN initiative;Cause of Death;Cells;Chronic;Cobalt;Collaborations;computer science;Corpus striatum structure;Creativeness;Dangerousness;Data;Deep Brain Stimulation;Development;digital imaging;Dislocations;Dopamine;Dopamine Agonists;Dopamine D2 Receptor;Electrodes;Electrophysiology (science);Engineering;Epilepsy;Equipment;Excision;falls;Focal Seizure;Fracture;frontal lobe;Frontal Lobe Epilepsy;Future;Genetic Recombination;Globus Pallidus;Image;image reconstruction;Imaging Techniques;Immunohistochemistry;Infusion procedures;Ion Channel;Label;Laboratories;Laboratory Research;Laboratory Study;Maps;Mediating;Methods;Microscopic;Modeling;Motor;Motor Cortex;Motor Seizures;Mus;neonatal hypoxic-ischemic brain injury;neural;Neuroanatomy;neuronal circuitry;Neurons;neuroregulation;new therapeutic target;novel;novel therapeutic intervention;Output;Partial Epilepsies;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;Prosencephalon;Publishing;receptor;reconstruction;Recurrence;Reporter;Research;Resolution;Risk;Science;Secondary to;Seizures;Site;Status Epilepticus;Structure;Structure of subthalamic nucleus;Substantia nigra structure;sudden unexpected death in epilepsy;Synapses;Synaptophysin;Techniques;temporal measurement;Testing;Thalamic structure;Thick;Thinness;Three-Dimensional Imaging;Tissues;Tonic - clonic seizures;tool;Violence;Viral;Visualization

PROJECT_TITLE: Secondarily generalized tonic clonic seizure; a functional anatomy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pain Research;Physical Activity;Prevention;Rehabilitation

PHR: Public Health Statement: The 2018 Center for Disease Control and Prevention (CDC) guidelines recommend that all adults engage in at least 150 minutes of physical activity weekly; however, uptake of PA is poor among patients who undergo total knee replacement, despite substantial pain relief as a result of the surgery. We propose a randomized trial of a multimodal behavioral intervention—telephonic health coaching and financial rewards—to encourage patients with osteoarthritis who have undergone a total knee replacement surgery to become more physically active. If the intervention proves effective and cost-effective, it could lead to a fundamental change in the strategy for increasing physical activity in patients undergoing total knee replacements.

PI_NAMEs: LOSINA, ELENA  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Adopted;Adult;arm;attentional control;Attitude;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;Behavioral Sciences;Belief;Centers for Disease Control and Prevention (U.S.);Clinical;clinical practice;comorbidity;cost;cost effective;cost effectiveness;critical period;Degenerative polyarthritis;design;economic incentive;Economics;Effectiveness;Ensure;evidence base;experience;Fatigue;financial incentive;fitbit;functional improvement;functional status;Future;good diet;Grant;Health;Health Benefit;Implant;improved;Incidence;Individual;innovation;Internet;Intervention;intervention effect;Investments;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Life Style;Measures;Medical;Methodology;Mind;moderate-to-vigorous physical activity;motivational enhancement therapy;multidisciplinary;multimodality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Obesity;Operative Surgical Procedures;Orthopedic Surgery;Orthopedic Surgery procedures;Pain;pain catastrophizing;Pain management;pain reduction;pain relief;patient oriented;Patients;Performance;personalized intervention;Persons;Physical activity;Policy Maker;poor sleep;Population;post intervention;Prevention Guidelines;primary outcome;protocol development;psychologic;Public Health;public health priorities;Quality of life;randomized trial;Recommendation;Rehabilitation therapy;Reporting;Research;Rewards;secondary outcome;sedentary;sleep quality;Telephone;Testing;Time;treatment as usual;treatment effect;Treatment Efficacy;tv watching;uptake;usual care arm;Work;World Health Organization

PROJECT_TITLE: Knee Arthroplasty Activity Trial (KArAT)


ORG_CITY: Los Angeles

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Many intrinsically disordered proteins (or proteins that do not fold into stable structures) can self-associate on biological surfaces, but understanding control of this phenomenon as a function of protein and surface modifications remains experimentally intractable. Herein, we propose to apply novel tools to understand how modifications control this phenomenon in specific model systems, with an explicit focus on modifications that occur in physiology and disease. This program will benefit the scientific community by introducing novel techniques and the public health by elucidating the biophysical behavior of proteins critical to neuronal function.

PI_NAMEs: CHUNG, PETER J (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affinity;alpha synuclein;Behavior;Biological;Biological Models;Biophysics;Communities;Disease;Goals;insight;Intention;Laboratories;Membrane;Methods;Microtubules;Modification;Molecular;Molecular Biology;multidisciplinary;Neurobiology;Neurodegenerative Disorders;Neurons;novel;Organelles;Physical condensation;Physiological;Physiology;Predisposition;programs;Protein Conformation;protein function;Proteins;Protocols documentation;Public Health;Recording of previous events;Research;Structure;Surface;Synaptic Vesicles;tau Proteins;Techniques;tool

PROJECT_TITLE: The molecular determinants of surface-templated self-association of intrinsically disordered proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Both increased awareness of cancer health disparities and increased diversity within the cancer research/oncology workforce are required to fully address the problem of cancer health disparities. The proposed Meharry Cancer Summer Research Program (SuRP) will provide undergraduate and medical students an opportunity to complete short-term, cancer focused research experiences that will enhance their understanding of cancer and cancer health disparities. It will also inspire participants to pursue careers in cancer research.

PI_NAMEs: STEWART, LAMONICA VANETTE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Affect;African American population;anti-cancer research;Area;Awareness;Basic Science;Bioinformatics;Biomedical Research;Cancer Biology;Cancer Center;cancer health disparity;cancer therapy;cancer type;career;career development;Clinical;Colon Carcinoma;combat;Communities;Data;Dentists;design;Development;Diagnosis;Disparity;Doctor of Medicine;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Epidemiology;ethnic minority;Ethnic Population;experience;Exposure to;Faculty;Funding;Goals;hands on research;Health;Health Disparities Research;Health Sciences;improved;interest;Knowledge;Learning;lectures;lens;literacy;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Minority;Minority Groups;Molecular;Motivation;Oncologist;Oncology;Oral;Participant;Physicians;posters;Prevention;Problem Solving;programs;racial minority;racial population;Research;Research Personnel;Research Project Grants;Research Training;Residencies;responsible research conduct;Science;Scientist;simulation;skills;Students;summer program;summer research;symposium;Training;Training Programs;Translational Research;tumor;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States;Work

PROJECT_TITLE: The Meharry Cancer Summer Research Program (SuRP)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Evidence indicates that older cancer survivors could significantly reduce the risk of experiencing chronic pain symptoms by engaging in physical activity, however, it is unknown how and when to best deliver physical activity intervention health messaging to reduce these symptoms. The proposed study will develop and test the timing of physical activity promotion messages to increase physical activity and reduce pain symptoms among older cancer survivors who experience chronic pain symptoms in a micro-randomized trial. The results from this study will provide a robust foundation for a R01 submission to conduct a just-in-time adaptive physical activity intervention to manage pain symptoms in older cancer survivors.

PI_NAMEs: MORELLI, WHITNEY A (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Activities of Daily Living;adaptive intervention;Affect;Age;Algorithms;Applications Grants;Area;Award;Behavioral Model;Cancer Survivor;Cancer Survivorship;career development;chronic pain;Data;design;Development;Development Plans;disability;discrete time;exercise intervention;experience;Experimental Designs;Feedback;Foundations;Funding;Future;Glean;Health;health communication;health literacy;Hour;human old age (65+);improved;Individual;International;Intervention;intervention delivery;K-Series Research Career Programs;Knowledge;Maintenance;Malignant Neoplasms;Measurement;Mentors;Mentorship;Mobility disability;Monitor;mortality;Nature;Notification;novel;older adult;Pain;Pain management;pain reduction;pain symptom;Participant;patient oriented;patient population;Patient Self-Report;persistent symptom;Personal Satisfaction;Persons;Physical activity;physical conditioning;Physical Function;physical symptom;Population;preservation;Probability;programs;Psyche structure;psychosocial;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;reduce symptoms;Research;Research Personnel;Risk;Risk Reduction;sedentary;side effect;skills;Survivors;Symptom Burden;Symptoms;Technology;Testing;theories;therapy design;Time;time use;Training;trial design;Work

PROJECT_TITLE: Micro-randomized trial of a physical activity intervention to manage pain symptoms among older cancer survivors

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The proposed project will develop algorithms for predicting and detecting glaucomatous progression in advanced glaucoma eyes tested longitudinally with visual field and optical imaging technologies and will make use of a very large amount of data, to do so. This proposal addresses the current NEI Glaucoma and Optic Neuropathies Program objectives of developing improved diagnostic measures to characterize and detect optic nerve disease onset and characterize glaucomatous neuro- degeneration within the visual pathways at structural and functional levels. Characterization of functional, structural, and microvascular loss in the central area of the retina and development of a clinically useful, novel, empirical system for predicting and detecting glaucomatous progression in advanced glaucoma will have a significant impact on the future of clinical care and reduce the burden of the disease.

PI_NAMEs: MOGHIMI ARAGHI, SASAN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;advanced disease;Affect;aggressive therapy;Algorithms;Angiography;archetypal analysis;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Blindness;Blood Vessels;burden of illness;care providers;Caring;Central Scotomas;central visual field;Classification;Clinical;clinical care;clinical decision-making;Cluster Analysis;Complex;cost;Data;Databases;deep learning;deep learning algorithm;Defect;density;Detection;detection method;Deterioration;Development;Diagnostic;disability;Disease;Dropout;Early Diagnosis;Economic Burden;Evaluation;Eye;field study;Floor;follow-up;functional status;Future;ganglion cell;Ganglion Cell Layer;Glaucoma;Goals;high risk;Image;Imaging technology;improved;Individual;Island;Knowledge;Machine Learning;machine learning model;macula;Mathematics;Measurement;Measures;Methods;Modality;Modeling;Monitor;multimodality;Nerve Degeneration;new technology;novel;Onset of illness;Open-Angle Glaucoma;Optic Disk;optic nerve disorder;Optical Coherence Tomography;optical imaging;patient oriented;Patients;Pattern;Pattern Recognition;prediction algorithm;programs;Public Health;Quality of life;Residual state;Retina;retinal nerve fiber layer;Risk Assessment;Series;Statistical Methods;Structure;Structure-Activity Relationship;System;Techniques;Testing;Texture;Thick;Thinness;United States National Institutes of Health;Vision;Visual Fields;Visual impairment;visual optics;Visual Pathways;Work

PROJECT_TITLE: Monitoring of Glaucoma Patients in Advanced Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE We recently identified a lactate-derived metabolite called N-lactoyl-phenylalanine (“Lac-Phe”) as the most significantly elevated metabolite in blood plasma after an intense exercise bout, which can robustly reduce food intake and body weight in obese mice. The proposed experiments will follow upon these observations to reveal the neurobiological basis for Lac-Phe hypophagia, which may identify Lac-Phe and the associated pathways as targets for weight management.

PI_NAMEs: XU, YONG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Address;Animal Feed;Anti-Obesity Agents;Appetite Stimulants;blood-brain barrier crossing;Body Weight;Body Weight decreased;Brain region;Chronic;CRISPR/Cas technology;Data;Eating;Electrophysiology (science);Energy Metabolism;Exercise;exercise training;experimental study;feeding;Feeding behaviors;FOS gene;Frequencies;Genetic;Genetic Recombination;glucose tolerance;High Fat Diet;Hormones;Hypothalamic structure;improved;insight;Intervention;Lateral;Maps;Mediating;Metabolic;Metabolic Diseases;Modeling;Mus;neural;neurobiological mechanism;Neurobiology;neurochemistry;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Nucleus solitarius;Obese Mice;Obesity;obesity risk;Output;parabrachial nucleus;paraventricular nucleus;Pathway interactions;Peptides;Permeability;pharmacologic;Phenylalanine;Physical activity;physical inactivity;Pilot Projects;Plasma;Population;Potassium;reduced food intake;Regimen;response;single-cell RNA sequencing;Strenuous Exercise;Structure of nucleus infundibularis hypothalami;Synapses;Synaptic plasticity;Testing;Thinness;Weight maintenance regimen

PROJECT_TITLE: Neurobiology for Lac-Phe Hypophagia

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE University of California, Los Angeles (UCLA), and California State University, Los Angeles (Cal State LA), will continue to administer the "IRACDA at UCLA" program. "IRACDA at UCLA" trains postdoctoral scholars in modern biomedical research at UCLA, and college level teaching at Cal State LA. Our goal is to train scholars how to employ modern teaching technologies to retain under-represented minorities in their majors at Cal State LA, and transition them to careers in the biosciences, to strengthen and diversify the national biomedical workforce.

PI_NAMEs: CAREY, MICHAEL F (contact);VILLANUEVA, CLAUDIO J

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Active Learning;Biochemistry;Biology;California;career development;Certification;cohort;Course Content;Credentialing;Critiques;Development;Discipline;Doctor of Philosophy;Education;Educational Assessment;Educational process of instructing;Educational workshop;experience;Funding;Generations;Goals;graduate school;improved;innovation;Institution;Leadership;Learning;learning community;lectures;Literature;Los Angeles;Mentors;Mission;National Institute of General Medical Sciences;novel;Occupations;Paper;pedagogical content;pedagogy;Positioning Attribute;Postdoctoral Fellow;Preparation;Program Development;programs;Records;Recruitment Activity;Research;Research Project Grants;Research Training;Scholarship;Science;Scientist;skills;STEM field;summer institute;teacher community;Teacher Professional Development;Training;undergraduate student;Universities;Writing

PROJECT_TITLE: IRACDA at UCLA

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE NBS has ushered in an era in which increasing numbers of parents are leaving the NBS experience with uncertain prognoses for their children. Despite lacking a comprehensive understanding of the benefits and harms of these uncertain prognoses, society has implemented mandatory public health screening for millions of newborns without the requisite appraisal of benefits and harms. The proposed project will provide a comprehensive assessment of the harms and benefits for parents of children with uncertain prognoses after NBS.

PI_NAMEs: GOLDENBERG, AARON J;TARINI, BETH A (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Age of Onset;Bioethics;Birth;Cessation of life;Child;Child Care;Child Health;Cohort Studies;coping mechanism;Data;disability;Disease;Early treatment;Ensure;Equilibrium;Ethics;evidence base;evidence based guidelines;experience;Face;Family;Future;Generations;Genetic;Genetic Counseling;Harm Reduction;Health;Health Services;Health Status;Hereditary Disease;improved;innovation;Interdisciplinary Study;Interview;Left;Methodology;National Human Genome Research Institute;National Institute of Child Health and Human Development;Neonatal Screening;Newborn Infant;operation;Parents;Patients;Phenotype;Policies;policy implication;policy recommendation;population based;prevent;Prognosis;prognostic;programs;Psychology;psychosocial;Public Health;Reaction;Recommendation;Reporting;Research Personnel;screening;screening panel;screening program;Screening Result;Severity of illness;Signs and Symptoms;Societies;stem;Stress;Support System;Symptoms;System;Time;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Emerging Challenges in NBS: Benefits and Harms of Receiving Uncertain Prognoses After NBS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SEIR-E(80)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Sharing large-scale functional genomics data is critical for scientific discovery, but comes with important privacy concerns related to the possible misuse of such data. This proposal will quantify and manage the rieslkasted to releasing functional genomics datasets, based on integrating inferred genotypes from the raw sequence files, signal tracks, and microbiome mapped sequences. Finally, we will develop file formats, statistical methodologies, and related software for anonymization of functional genomics data that enable open sharing.

PI_NAMEs: GERSTEIN, MARK BENDER (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Assessment tool;Biology;Bite;Calibration;ChIP-seq;clinically relevant;Code;Computer software;computerized data processing;Consent;Data;Data Files;data mining;Data Science;Data Set;data sharing;Databases;Diet;Disease;DNA sequencing;Environment;Equilibrium;experimental study;Extravasation;file format;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Glean;Hi-C;Human;human tissue;Individual;interest;large datasets;Laws;Learning;Letters;Life Style;Link;Machine Learning;Malignant Neoplasms;Maps;Measures;Medical Research;Methodology;Methods;microbial;microbiome;Mining;Motivation;open data;Participant;Patients;Phenotype;Positioning Attribute;Predisposition;Privacy;privacy preservation;privacy protection;Privatization;Procedures;Process;Protein Isoforms;Protocols documentation;Provider;Pythons;Quantitative Trait Loci;Research Personnel;Risk Assessment;RNA Splicing;Sampling;Sequence Alignment;Sequence Deletion;Signal Transduction;Single Nucleotide Polymorphism;Smoker;social;Source;Techniques;The Cancer Genome Atlas;Tissues;tool;transcriptome sequencing;Variant

PROJECT_TITLE: Enhancing open data sharing for functional genomics experiments: Measures to quantify genomic information leakage and file formats for privacy preservation

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Digestive Diseases;HIV/AIDS;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This proposal will investigate changes to the viral and bacterial communities of the gut in people who take medicine to prevent HIV infection (PrEP). I will analyze stool and blood samples from volunteers to measure what viruses and bacteria are there, how they change after 3 months of using PrEP, and how those changes affect inflammation in the intestines or the entire body. A better understanding of these changes will allow us to improve the safety and tolerability of PrEP in addition to potential probiotic, prebiotic, or anti-inflamatory interventions to increase intestinal health.

PI_NAMEs: MAUST, BRANDON SWARTZ (contact)

PROGRAM_OFFICER_NAME: DEY, BARNA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Anti-Inflammatory Agents;Anti-Retroviral Agents;Antibiotics;Area;Award;Bacteria;bacterial community;bacteriome;Bacteriophages;Biometry;Blood;Blood specimen;career development;Career Mobility;Cells;Child;Clostridium difficile;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;Computational Biology;Control Groups;Development;Development Plans;Disease;DNA;dysbiosis;emtricitabine;Enrollment;Enteral;enteric dysbiosis;Epithelial Cells;Epithelium;experimental study;Feces;Fumarates;Functional disorder;Future;Generations;Genetic Markers;global health;Goals;Growth;gut inflammation;gut microbiota;Health;HIV;HIV Infections;Human;Immune;Immune system;Immunity;improved;In Vitro;Incidence;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Intervention;Intestines;Literature;Measures;Medicine;member;metagenome;metagenomic sequencing;Metagenomics;Methods;microbial;microbicide;microbiota;microorganism interaction;Modeling;Mucositis;multiple omics;Mus;novel;Nucleosides;Nutritional;Organism;Participant;particle;pathobiont;Pathogenicity;Persons;Physicians;Population;pre-exposure prophylaxis;prebiotics;Predatory Behavior;Predisposition;prevent;Probiotics;Prokaryotic Cells;Prophages;Research;resident commensals;Resources;response;Reverse Transcriptase Inhibitors;Risk Factors;Risk Reduction;RNA Sequences;Safety;Scientist;Series;Shapes;Shotgun Sequencing;Signal Transduction;Specimen;stool sample;Structure;symbiont;systemic inflammatory response;Techniques;Tenofovir;Testing;Therapeutic Intervention;Training;Ulcerative Colitis;Validation;Viral;Viral Genome;Virion;virome;Virus;Visit;volunteer

PROJECT_TITLE: Changes in Enteric Microbiota and Inflammation with HIV PrEP

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Mitochondrial function underlies a broad spectrum of health and disease conditions but many of the mechanisms remain unknown. This study will provide novel knowledge of mitochondrial function in the aspect of mitochondrial proton leak, and its key mechanisms. Moreover, we will provide a novel group of drugs that modulate mitochondrial proton leak to regulate mitochondrial function.

PI_NAMEs: ZHANG, HUILIANG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Adenine Nucleotides;Aging;ATP phosphohydrolase;Back;Biological Assay;Buffers;Cardiac;Cell Energetics;cell type;Cells;Complex;Consumption;Diabetes Mellitus;Disease;Drug Modulation;Electron Transport;Exclusion;Functional disorder;Genetic Diseases;Genus Hippocampus;Health;Homeostasis;Inner mitochondrial membrane;Ion Pumps;Knowledge;Life;Malignant Neoplasms;Measurement;Measures;Mediating;Membrane;Metabolic;metabolic rate;Methods;Mitochondria;Molecular;Muscle;novel;novel therapeutics;Obesity;Organism;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Permeability;pH gradient;physical property;physical separation;prevent;Process;Production;Proton Pump;Protons;Regulation;Respiratory Chain;Role;Saponins;Stress;Thermogenesis;Transgenic Mice

PROJECT_TITLE: Deciphering the mitochondrial proton leak

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Bridging the gap between biomedical discoveries and clinical practice in the United States and elsewhere is challenging. Scientists and doctors often have surprisingly distinct types of professional training in how to think and communicate about their work. We are proposing in this application to continue to train physician-scientists in both rigorous experimental science and clinical medicine, allowing them to interact with both worlds, imbue their own research programs with medically relevant themes, and push new discoveries forward to benefit public health.

PI_NAMEs: GARCIA-BLANCO, MARIANO A. (contact)

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Community-Driven Indigenous Research, Cultural Strengths & Leadership to Advance Equity in Substance Use Outcomes (CIRCLE) Center aims to address drug use related health problems and deaths in collaboration with American Indian (i.e., Indigenous) communities. The proposed CIRCLE Center will fuel a hub of Indigenous- driven research and training to understand and address drug use inequities across diverse tribal cultures and contexts. Through research, training, and outreach, we will respond to calls from Indigenous Peoples for enhanced focus on recovery and prevention, sources of strength, culture- and family-based approaches to wellness, and policy solutions.

PI_NAMEs: BARLOW, MARY ALLISON;WALLS, MELISSA L. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;Address;Alaska Native;Alcohol abuse;Alcohol consumption;alcohol-related death;Ally;American Indians;Area;Attention;burden of illness;Centers of Research Excellence;Cessation of life;Collaborations;combat;Communities;community based participatory research;Community Services;coping;COVID-19 pandemic;Data;Development;Drug abuse;drug abuse prevention;Drug usage;Education;Equity;evidence base;experience;Family;Fostering;Goals;Harm Reduction;Health;health equity;Heterogeneity;Indigenous;indigenous community;Inequity;innovation;Intervention;intervention effect;Leadership;Life;Longevity;Measures;Methodology;Methods;multidisciplinary;National Institute of Drug Abuse;Native-Born;novel;Outcome;outreach;overdose death;Pathway interactions;Pattern;Personal Satisfaction;personalized approach;Persons;Pharmaceutical Preparations;Pilot Projects;Policies;Policy Maker;Population;Premature Mortality;Prevalence;Prevention;programs;promote resilience;protective factors;Public Health;Racial Equity;Recovery;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;Risk Factors;Science;Scientific Advances and Accomplishments;Services;Shapes;social health determinants;socioeconomics;Source;stressor;Structure;substance misuse;substance misuse prevention;substance use;System;Time;Training;Training Activity;Translating;trend;Tribally Based Participatory Research;Tribes;uptake;Work;Workforce Development

PROJECT_TITLE: Community-Driven Indigenous Research, Cultural Strengths & Leadership to Advance Equity in Drug Use Outcomes (CIRCLE)


NIH_SPENDING_CATS: American Indian or Alaska Native;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: WALLS, MELISSA L. (contact)

PROJECT_TERMS: Address;Advisory Committees;Ally;Attention;career;career development;Centers of Research Excellence;Collaborations;Colorado;Communities;community based participatory research;community partners;Data;Drug Addiction;Drug usage;Education;Educational Activities;Elderly;Ensure;Equity;Evaluation;experience;Fostering;Future;Health;Indigenous;indigenous community;Inequity;Internet;Lead;Leadership;member;mentoring community;Mentorship;multidisciplinary;Multimedia;multimodality;National Institute of Drug Abuse;next generation;organizational structure;Outcome;Output;outreach;Pilot Projects;Policies;Procedures;Process;Productivity;programs;Progress Reports;public education;Public Health;Public Health Practice;Publications;Research;Research Activity;Research Personnel;Research Project Grants;residence;Resource Sharing;Resources;Services;shared decision making;social media;Strategic Planning;Structure;success;symposium;synergism;timeline;Training;Training Programs;tribal community;tribal Nation;Tribes;United States;Universities;Update;webinar;Work

PROJECT_TITLE: Administrative Core


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE – OVERALL Technology and digital media (TDM) have impact on adolescents’ behaviors, well-being and their developing brains. In this P01 program proposal, we will collect data from adolescents over time leveraging several sources, including self-report, observed social media data and functional MRI. This integrated approach to longitudinal data collection from a shared adolescent participant pool will lead to novel analyses and findings, such that this P01 program will advance conceptual models and inform new interventions to improve adolescent health.

PI_NAMEs: MORENO, MEGAN A. (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Behavior;Adolescent Development;adolescent health;adolescent health outcomes;Adolescent Risk Behavior;Affect;alcohol behavior;Area;Behavior;behavioral health;Benefits and Risks;Big Data;Biometry;Brain;clinical translation;Cognition;Collaborations;Communities;Complex;Consumption;Data;Data Collection;data integration;Data Reporting;Development;Developmental Process;digital media;digital technology;Ecological momentary assessment;Elements;emotion regulation;Emotional;Ensure;experience;Functional Magnetic Resonance Imaging;Funding;Future;gender minority youth;Generations;Goals;Grant;Growth;Health;Health behavior;improved;Individual;Information and Media;Infrastructure;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Intervention;Interview;Knowledge;longitudinal design;Longitudinal Studies;Measures;media use;meetings;Mental Health;Methodology;Methods;Modeling;Modernization;neurodevelopment;novel;Outcome;Participant;Patient Self-Report;peer;Perception;Personal Satisfaction;Prevention;Process;Program Research Project Grants;programs;recruit;Research;Research Personnel;Resources;Risk Behaviors;Schools;Science;Sexual and Gender Minorities;social media;Source;Structure;Students;surveillance data;Surveys;synergism;Technology;Textiles;theories;Time;tool;Universities;Well in self;Wisconsin;Work

PROJECT_TITLE: A longitudinal study investigating TDM and adolescent health and development: Brain, Behavior and well-Being


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: HAROZ, EMILY  (contact)

PROJECT_TERMS: addiction;Address;Age;Ally;Area;Automobile Driving;Biological Models;career;Code;Collaborations;Communities;community academic partnership;community partners;community partnership;COVID-19 pandemic;Data;Data Collection;data management;data sharing;design;Development;Discipline;disparities in morbidity;Drug usage;Ecosystem;Epidemiology;Equity;Evaluation;Extramural Activities;Fostering;Funding;Future;Gender;Generations;healing;Health;health inequalities;Heterogeneity;implementation science;Indigenous;indigenous community;Inequity;innovation;Institution;Intervention;intervention effect;Journals;Leadership;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;mortality disparity;Native-Born;novel;Outcome;outcome disparities;Personal Satisfaction;personalized approach;Persons;Pharmaceutical Preparations;Pilot Projects;Policies;Prevention Research;Procedures;Process;Productivity;programs;Public Health;Publications;Race;Recovery;recruit;repository;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Sea;Services;Source;Statistical Data Interpretation;student training;substance abuse prevention;substance use;substance use prevention;symposium;System;Training and Education;Trauma;United States;Universities;web site;Work;Writing

PROJECT_TITLE: Research Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Prevention

PHR: PROJECT NARRATIVE – PROJECT 1 Not applicable. Per the Funding Opportunity Announcement PA-HD-22-009, the Project Narrative is not required for the Project or Core components.

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Behavior;Adolescent Development;adolescent health;Affect;Age;aged;Alcohol consumption;Area;Attitude;Attitude to Health;Behavior;behavior prediction;Brain;Child Rearing;Complex;Consumption;Data;Data Collection;Development;digital media;Ecological momentary assessment;Enrollment;experience;Exposure to;fitness;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Funding Opportunities;Future;Goals;health assessment;Health behavior;Homicide;Injury;Interdisciplinary Study;interest;Intervention;Learning;Link;longitudinal design;Longitudinal Studies;Measures;media use;Medial;Methods;Modeling;Morbidity - disease rate;mortality;neural;neurodevelopment;Neurosciences;nutrition;Parents;Participant;Patient Self-Report;Pattern;Personal Satisfaction;Persuasive Communication;Physical activity;Population;Predictive Value;Predictive Value of Tests;Prefrontal Cortex;Process;Program Research Project Grants;programs;recruit;Reporting;Research;Research Design;Research Personnel;Risk;Risk Behaviors;Risk Reduction Behavior;Sampling;self reported behavior;social media;social norm;Structure;substance use;Suicide;Surveys;Technology;Testing;therapy development;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Using TDM to understand mechanisms in adolescent health and risk behavior


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE – PROJECT 2 Not applicable. Per the Funding Opportunity Announcement PA-HD-22-009, the Project Narrative is not required for the Project or Core components.

PI_NAMEs: CASCIO, CHRISTOPHER N (contact)

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Adolescent Behavior;Adolescent Development;adolescent health;Affect;Age;Anterior;Area;Behavior;behavioral health;Brain;Brain region;Communications Media;Complex;Cues;Data;Development;digital media;Distress;Dorsal;Environment;Exclusion;experience;Exposure to;Friends;Functional Magnetic Resonance Imaging;Funding Opportunities;Health;Health behavior;health difference;high school;Individual Differences;Insula of Reil;Interdisciplinary Study;interest;Lead;Literature;Longitudinal Studies;Measures;media use;Medial;Mental Health;neural;neurodevelopment;Outcome;Pain;Participant;peer;Personal Satisfaction;Persons;Prefrontal Cortex;Published Comment;Reaction;Reporting;Research;reward processing;Rewards;Risk Behaviors;Risk Taking;Site;social;social culture;Social Development;social exclusion;social inclusion;social media;Technology;Testing;Time;Ventral Striatum

PROJECT_TITLE: Using functional magnetic resonance imaging to understand how positive and negative TDM experiences relate to mental and behavioral health


ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  A hallmark of cancer is the ability of malignant cells to evade various forms of cell death including ferroptosis. We postulate that activation of the MT-1G pathway limits ferroptosis in human hepatocellular carcinoma, the third leading cause of cancer-related death worldwide. Our proposal will provide new insight into understanding the mechanism of ferroptosis and guide future development of MT-1G-based novel anticancer therapeutic strategies.

PI_NAMEs: TANG, DAOLIN  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Alanine;Animal Model;anti-cancer therapeutic;anti-tumor immune response;Apoptosis;BAY 54-9085;C-terminal;Cancer Biology;cancer cell;Cancer Etiology;Caspase;CD8-Positive T-Lymphocytes;Cell Death;Cell model;Cells;Cessation of life;Clinical;cofactor;Complex;conditional knockout;Development;erastin;exosome;extracellular;FPS-FES Oncogene;Future;Genetic Transcription;glycogen synthase kinase 3 beta;Glycyrrhizic Acid;Hepatology;HIF1A gene;HMGB1 gene;Human;Immunosuppression;improved;In Vitro;in vivo;inhibitor;insight;Knockout Mice;Lipid Peroxidation;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Metallothionein;Modification;Molecular;molecular modeling;Mus;mutant;Mutation;neoplastic cell;neutralizing antibody;novel;Nuclear;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Plasmids;Play;Primary carcinoma of the liver cells;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;Receptor Activation;receptor for advanced glycation endproducts;Regulation;Resistance;Role;Serine;Site;small hairpin RNA;Sulfasalazine;T-Lymphocyte;Testing;TLR4 gene;transcription factor;Transcriptional Regulation;tumor;Tumor Immunity;Up-Regulation

PROJECT_TITLE: Mechanisms of Ferroptotic Cancer Cell Death


PI_NAMEs: O’KEEFE, VICTORIA  (contact)

PROJECT_TERMS: Address;Alaska Native;Ally;American Indians;Area;Award;career;Cherokee Nation;Child;Chippewa;Collaborations;Communication;Communities;community based research;community research;design;Development;Disparity;doctoral student;Drug usage;Educational workshop;Ensure;Equity;Ethics;ethnic diversity;experience;Funding;Funding Opportunities;Goals;Grant;Health;health equity;health equity promotion;Health Personnel;Indigenous;indigenous community;Inequity;innovation;Knowledge;Leadership;Learning;Lived experience;meetings;Mentors;Mentorship;Methodology;National Institute of Drug Abuse;online community;Outcome;Participant;Pilot Projects;Policies;Positioning Attribute;Prevention;Process;programs;Protocols documentation;Public Health;Race;Racial Equity;Records;reduced substance use;Request for Proposals;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Science;Seminole Tribe;skills;Structure;substance use;substance use prevention;success;supportive environment;symposium;synergism;Training;tribal Nation;United States National Institutes of Health;urban Native American;virtual;Work;Writing

PROJECT_TITLE: Pilot Project Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PHR: PROJECT NARRATIVE – PROJECT 3 Not applicable. Per the Funding Opportunity Announcement PA-HD-22-009, the Project Narrative is not required for the Project or Core components.

PI_NAMEs: SELKIE, ELLEN MARIE (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Development;adolescent health;Adult;Affect;Age;aged;Aggressive behavior;Area;Behavior;Brain;bullying;Characteristics;Child;Clinical;clinical diagnosis;comparison group;Complement;Consumption;contextual factors;cyberbullying;Data;Data Collection;Development;digital;digital media;Distress;Economics;Emotional;Enrollment;Environmental Risk Factor;Ethnography;Exclusion;experience;Facebook;Foundations;Funding Opportunities;Future;gender minority youth;Generations;Goals;Health;improved outcome;Individual;insight;Instagram;instrument;interest;Intervention;Interview;Learning;lens;Life;Linguistics;Loneliness;Longitudinal Studies;Measures;media use;Mental Depression;Mental Health;Methods;minority stress;Modeling;Moods;novel;Outcome;Participant;participant observation;Pattern;peer;Personal Satisfaction;physical conditioning;Population;Privacy;Program Research Project Grants;psychologic;Qualitative Research;recruit;Research;Research Design;Risk;risk mitigation;Sampling;self esteem;Sexual and Gender Minorities;sexual minority youth;social;Social Desirability;Social Functioning;social media;Social support;substance use;suicidal;Surveys;Technology;Testing;TikTok;Time;Twitter;vulnerable adolescent;Well in self;Work

PROJECT_TITLE: Using mixed methods to evaluate self- and other-generated TDM content as predictors of socioemotional well-being in sexual and gender minority (SGM) and non-SGM adolescents


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: 5/14/2019 R24rev 042519 - Google Docs Narrative: We propose to develop an accessible high-resolution map of T cell development within lymphoid tissue that incorporates simultaneous measurements of mRNA and surface proteins, as well as spatial information about the location of individual cells within lymphoid tissues. https://docs.google.com/document/d/1_oSwBBQ337VeESg2j8dqZgAF5sJxKiJ4SQFyn4u7QQE/edit 3/30

PI_NAMEs: ROBEY, ELLEN A (contact);STREETS, AARON ;YOSEF, NIR

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: 3-Dimensional;Anatomy;Antibodies;Area;Bar Codes;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Surface Proteins;cell type;Cells;cohort;Communities;Computational Biology;computational pipelines;Computer Analysis;Computer software;Computing Methodologies;Data;Development;Engineering;Environment;Flow Cytometry;Four-dimensional;Gene Expression Profile;Genes;Genetically Engineered Mouse;imaging modality;Immune;Immune response;Immune system;Immunology;Individual;Infection;interdisciplinary approach;interest;Internet;laser capture microdissection;Lasers;Location;Lymphoid Tissue;Maps;Mature Thymocyte;Measurement;Membrane Proteins;Messenger RNA;Metadata;Methods;Microdissection;Microscopy;Molecular;mRNA Expression;multiphoton imaging;multiphoton microscopy;Names;new technology;novel strategies;optical imaging;Pathway interactions;Pattern;Preparation;protein expression;Proteins;Regulatory T-Lymphocyte;Research;Research Personnel;Resolution;Resources;RNA;RNA analysis;Services;Signal Transduction;single cell analysis;single cell genomics;single-cell RNA sequencing;Slice;Structure of thymic medulla;Suspensions;System;T-Cell Development;T-Lymphocyte;temporal measurement;Thymic Tissue;thymocyte;Thymus Gland;Time;Tissues;tool;transcriptome;user-friendly;web portal;Wild Type Mouse

PROJECT_TITLE: Spatial and temporal mapping of cell fate within lymphoid tissue


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE – ADMINISTRATIVE CORE Not applicable. Per the Funding Opportunity Announcement PA-HD-22-009, the Project Narrative is not required for the Project or Core components.

PROJECT_TERMS: Address;Adolescence;Adolescent Development;adolescent health;Advisory Committees;Area;Behavior;Biometry;Brain;Caliber;Collaborations;Committee Members;Communication;Communities;cost effective;Data;design;Development;digital media;Discipline;Ensure;experience;Faculty;Friends;Funding;Funding Opportunities;Goals;graduate student;Grant;Growth;Health;Infrastructure;Institution;Interdisciplinary Study;Lead;Learning;longitudinal design;Longitudinal Studies;Medical;meetings;member;Modeling;Nature;next generation;novel;Outcome;Participant;Pathway interactions;Personal Satisfaction;Principal Investigator;Process;Productivity;Program Research Project Grants;programs;recruit;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schedule;Schools;Services;Structure;Students;Technology;theories;Time;timeline;undergraduate student;Universities;Vertebral column;Visual;Wisconsin;Work


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE While adhesive membrane proteins are essential for maintaining tissue integrity, it is extremely challenging to map their interactions using traditional biochemical methods. The first goal of this proposal is to develop a molecular technology to discover novel membrane protein interactions in cells. The second goal of this proposal is to use this technology to resolve the assembly and organization of desmosomes, an essential adhesive structure that mediates the integrity of tissues like the epidermis and heart.

PI_NAMEs: SIVASANKAR, SANJEEVI  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: adhesion receptor;Adhesions;Adhesives;Atomic Force Microscopy;Benchmarking;Binding;Biochemical;Biological Assay;biophysical techniques;biophysical tools;Biophysics;Cadherins;Cell Adhesion;Cell Adhesion Molecules;Cell Extracts;Cell membrane;Cell surface;cell type;Cell-Cell Adhesion;Cells;Cellular Structures;Chemicals;Computer Simulation;Coupling;Cytoplasm;Data;desmocollin;Desmosomes;Disease;E-Cadherin;Environment;Enzymes;Epidermis;Epithelial Cells;experimental study;Exposure to;extracellular;Fluorescence Microscopy;Funding;Genes;Goals;Heart;Heart Diseases;Human;In Situ;Inherited;insight;instrumentation;Integral Membrane Protein;Integrins;Kinetics;Label;Ligands;Maps;Measurement;Measures;Mechanical Stress;Mechanics;Mediating;Membrane;Membrane Proteins;Methods;Molecular;Molecular Conformation;Monitor;mutant;Mutation;new technology;novel;Organelles;Pathology;Play;Positioning Attribute;Proteins;prototype;Receptor Protein-Tyrosine Kinases;recruit;Role;Signal Transduction;single molecule;single-molecule FRET;Skin;Structure;Technology;Testing;Tissues;tool;ultra high resolution;Visualization

PROJECT_TITLE: Methods for mapping cell adhesion receptors

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Adolescent Sexual Activity;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Suicide;Teenage Pregnancy;Women's Health Research

PI_NAMEs: BARLOW, MARY ALLISON (contact)

PROJECT_TERMS: 19 year old;Abstinence;addiction;Address;adolescent substance use;Affect;Affordable Care Act;Age;Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;arm;Behavioral;behavioral health;Black, Indigenous, People of Color;Child;Child Development;Child Rearing;children of color;Communities;community based participatory approach;Country;Data;depressive symptoms;design;Development;disparity gap;Drug usage;early childhood;Effectiveness;Emotional;Ensure;Equity;Ethnic Population;evidence base;Expectancy;Family;Feeling suicidal;follow-up;Follow-Up Studies;Future;Generations;Goals;group intervention;Growth;health equity;health inequalities;Home;Home visitation;illicit drug use;Impairment;improved;Indigenous;Individual;intergenerational;Intervention;Intervention Trial;Interview;Knowledge;Leadership;Life Cycle Stages;marginalized population;Marijuana;maternal stress;Mediator;Medical;Medical Records;meetings;Mental Depression;Mental Health;Methodology;Mothers;multiple drug use;National Institute of Drug Abuse;Outcome;Overdose;overdose death;Parents;Participant;Pathway interactions;Patient Self-Report;personalized approach;Policies;post intervention;Postpartum Period;Pregnancy;prenatal;programs;protective factors;Psyche structure;Race;racial population;racism;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;reduced substance use;Research;Research Project Grants;Resources;Risk;Risk Factors;Sampling;secondary outcome;social;Social Problems;standard care;Stress;substance use;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;teenage mother;Training;Transportation;Trauma;trial enrollment;tribal community;Tribal group;Tribes;Well Child Visits;Well in self;young adult;Youth

PROJECT_TITLE: Research Project 1


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE – RECRUITMENT & RETENTION CORE Not applicable. Per the Funding Opportunity Announcement PA-HD-22-009, the Project Narrative is not required for the Project or Core components.

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Age;Back;Behavior;Brain;Communication;Communities;cost effective;Data;Data Collection;data sharing;design;Development;digital media;Enrollment;Ensure;experience;Functional Magnetic Resonance Imaging;Funding Opportunities;Goals;Grant;Guidelines;Health;human subject;human subject protection;Incentives;Individual;Infrastructure;Institution;Knowledge;Lead;Longitudinal Studies;Modeling;Motivation;Outcome;Participant;participant retention;Pathway interactions;patient engagement;Personal Satisfaction;Principal Investigator;Process;Productivity;Program Research Project Grants;programs;Protocols documentation;Publishing;recruit;repository;Research;Research Personnel;research study;Resources;Schedule;social media;Structure;success;synergism;Technology;theories;Time;timeline;Universities;university student;Vertebral column;Wisconsin;Work;Youth

PROJECT_TITLE: Recruitment & Retention Core