NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pain Research;Pediatric;Physical Activity;Prevention

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Regular physical activity (PA) is an important component in the management of chronic musculoskeletal pain in adolescents (CMSKP), but because of fear of pain, PA is often difficult for these youth. This K23 evaluates positive resilience factors that are important to pain coping (i.e., self-efficacy, motivation, and psychological flexibility), how these resilience factors are related to PA (including factors specific to decreased sedentary activity), potential mediators of the relationship between resilience and PA (e.g., pain modulation, stress dysregulation), and then develops a novel resilience-based intervention to increase PA in adolescent CMSKP. Results from this study and completion of activities in the training plan will provide the candidate with a strong foundation to launch an independent research program on the improvement of health for children and adolescents with CMSKP.

PI_NAMEs: BLACK, WILLIAM ROBERT (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academic Medical Centers;Accelerometer;acceptability and feasibility;Adolescent;Adult;Affect;Aftercare;Age;awake;Behavior Therapy;Behavioral;bone;Buffers;career development;Child Health;Childhood;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;Clinical Research;clinical translation;Clinical Trials Cooperative Group;Cognitive;cohort;Complement;conditioned pain modulation;coping;Coping Skills;Cross-Sectional Studies;Data;Development;Development Plans;Diagnosis;early life stress;Effectiveness;Evaluation;exercise intervention;experience;Extramural Activities;Feasibility Studies;Feedback;flexibility;Foundations;Fright;functional disability;Funding;Goals;Growth and Development function;Hydrocortisone;implementation intervention;improved;innovation;Intervention;Intervention Studies;Interview;Joints;Knowledge;Ligaments;Light;Manuals;Measures;Mediating;Mediator;Mentorship;Modeling;moderate-to-vigorous physical activity;Motivation;Muscle;novel;optimal treatments;Outcome;Pain;pain catastrophizing;Pain Clinics;pain inhibition;Pain interference;Pain management;Pain Measurement;pain patient;pain perception;pain processing;Pathway interactions;patient oriented;Patient Self-Report;Patients;pediatric department;perceived stress;Physical activity;Physical Function;Physiology;pilot test;potential biomarker;programs;promote resilience;psychobiologic;psychologic;Psychological Factors;Recommendation;recruit;Regulation;Reporting;Research;Research Design;research faculty;Research Institute;resilience;resilience factor;response;Risk;Risk Factors;Salivary;Science;sedentary;sedentary activity;Self Efficacy;Sensory;Stress;Stressful Event;Structure;Teenagers;Testing;therapy development;Time;Training;Translational Research;Treatment outcome;treatment program;treatment services;treatment strategy;United States;Waiting Lists;Youth

PROJECT_TITLE: Resilience Factors, Pain, and Physical Activity in Adolescent Chronic Musculoskeletal Pain

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes

ORG_CITY: DUARTE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Individuals with diabetes experience significant primary and secondary complications, costing an estimated annual $569 billion dollars of care in the United States for 34 million Americans, with annual average medical costs of $16,752 per person. The central importance of human islets in the pathology of this disease, and demonstrated use of islets as an unparalleled experimental and treatment resource, has led to continued demand for human islets from healthy donors, and an escalating demand for specific islet preparations from donors with Type 2 Diabetes and rare diseases. Maintenance of a large scale islet distribution network such as the Integrated Islet Distribution Program (IIDP) is critical to provide researchers with access to this precious resource, to advance discoveries and progress in the field of diabetes mellitus research.

PI_NAMEs: EVANS-MOLINA, CARMELLA ;NILAND, JOYCE CAROL (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Algorithms;American;Basic Science;Biological Assay;Biomedical Research;Businesses;Cadaver;Caring;Cities;Communication;Communications Media;Communities;cost;cost estimate;Country;Custom;Data;data integration;data repository;Development;Diabetes Mellitus;Disease;Drug or chemical Tissue Distribution;Electronics;Ensure;Equity;experience;Fees;Fostering;Functional disorder;Funding;Future;Genetic;Genetic Risk;Genotype;Goals;Grant;Human;improved;Individual;Informatics;insight;interest;interoperability;Investments;islet;Islets of Langerhans;Laboratories;Maintenance;Medical Care Costs;meetings;Mission;Modeling;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Insulin-Dependent Diabetes Mellitus;Notification;novel;Pancreas;Pathology;Peer Review;Persons;Phenotype;phenotypic data;Pilot Projects;Policies;Preparation;Prevention;Procedures;Process;Production;programs;Protocols documentation;Provider;Publications;Qualifying;quality assurance;Rare Diseases;Recommendation;Recovery;Reproducibility;Research;Research Personnel;Resources;Sampling;Science;Scientist;Secure;Services;Standardization;System;Technology;Time;Tissues;tool;trend;Trust;United Network for Organ Sharing;United States;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Integrated Islet Distribution Program (U24) - 2021


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Data suggest that individuals with high food responsiveness do not respond to behavioral weight loss programs. The purpose of this application is to evaluate weight loss among adults with overweight and obesity who are high on food responsiveness randomized to one of three treatment arms; our novel model (ROC+: Regulation of Cues Enhanced program) which targets food responsiveness, behavioral weight loss, and an active comparator. Results of this study could to inform new treatment pathways based on appetitive traits and provide an alternative model for the treatment of adults with overweight and obesity.

PI_NAMEs: BOUTELLE, KERRI N (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: acceptability and feasibility;active comparator;Adult;adult obesity;Aftercare;arm;Awareness;Behavior;Behavior Therapy;Behavioral;behavioral phenotyping;Body mass index;Body Weight decreased;clinical decision-making;Cognition;Coping Skills;craving;cue reactivity;Cues;Data;demographics;design;Desire for food;dietary restriction;Eating;eating in absence of hunger;Educational Activities;Effectiveness;efficacy testing;Energy Intake;Environment;Equation;Exhibits;Exposure to;Failure;follow-up;Food;Goals;Hunger;Hyperphagia;improved;Individual;Laboratories;Maintenance;Measures;Mediator;Medical;Modeling;Monitor;novel;nutrition;Obesity;obesity treatment;Overweight;Participant;Pathway interactions;Patient Self-Report;Perception;Phenotype;Physical activity;Predisposition;programs;Protocols documentation;psychoeducation;psychologic;Psychophysiology;Randomized;Randomized, Controlled Trials;recruit;Regulation;Research;response;Risk Factors;Satiation;skills training;standard care;success;targeted treatment;Techniques;Testing;theories;therapy development;Time;Training;trait;treatment arm;treatment effect;Treatment Efficacy;treatment group;treatment program;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Targeting food cue responsiveness for weight loss

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Persistent pain after limb injury, surgery to the extremities and other forms of orthopedic trauma is common and results in poor functional recovery as well as delay in return to normal activities. Cognitive decline, anxiety and mood disturbances are additional consequences of unresolved pain. Chronic pain after limb injury is especially important to the VA where limb injuries are often treated and large joint, hand and foot surgery are commonly performed. In addition, recovery from limb injuries is important to the military as more than half of all battle-related wounds involve the extremities. Moreover, persistent pain increases exposure to opioids, a problem particularly severe amongst Veterans. In fact, perioperative and peritraumatic opioid use is a major risk factor for subsequently developing opioid use disorder, the condition lying at the heart of the nation’s opioid epidemic. Thus, there is a strong need for novel approaches to augment recovery from injury, reduce chronic pain and prevent additional types of adverse sequelae.

PI_NAMEs: CLARK, DAVID J. (contact)

PROJECT_TERMS: Acceleration;Address;adverse outcome;affective disturbance;antagonist;Antibodies;Anxiety;attenuation;Autoantibodies;Autoantigens;Autoimmune Responses;Autoimmunity;autoinflammation;B cell differentiation;Behavioral;behavioral outcome;Biochemical;Biological;C5a anaphylatoxin receptor;Chronic;Chronic disability;chronic pain;chronic pain patient;Chronic pain syndrome;Clinical;Clinical Protocols;Cognitive;Collaborations;Complement;Complement 5a;Complement Activation;Complement Membrane Attack Complex;complement system;Complex Regional Pain Syndromes;cytokine;design;Development;Dimensions;Disabling;draining lymph node;Emotional;experimental study;Exposure to;Fiber;foot;Foundations;Fracture;functional decline;functional loss;Funding;Generations;Genetic;genetic predictors;Goals;Hand;Heart;Human;Hypertrophy;immune activation;Immune response;Immune system;Immunoglobulin M;Immunologics;Immunology;immunoregulation;Impaired cognition;improved;Inflammation Mediators;Injections;injured;Injury;injury recovery;Interleukin-6;Interruption;Joints;limb fracture;limb injury;Limb structure;Mediating;Mediator;Memory;Memory Loss;Military Personnel;Modeling;Motion;Mus;Neurocognitive Deficit;Neurons;neuropsychiatry;Neuropsychology;Nociception;novel;novel strategies;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use;opioid use disorder;Orthopedics;Outcome Measure;Pain;pain reduction;Pain Research;Parasympathetic Nervous System;Pathway interactions;Patients;Perioperative;Peripheral;Persistent pain;Pharmaceutical Preparations;pharmacologic;Physical Medicine;Positioning Attribute;prevent;Production;Productivity;Recovery;Recovery of Function;Rehabilitation therapy;Research;Risk Factors;Rodent;Rodent Model;Role;Sampling;Severities;Signal Transduction;Skin;small molecule;Spinal Cord;Structure of germinal center of lymph node;Sympathetic Nerve Block;Sympathetic Nervous System;Testing;Therapeutic;Tibial Fractures;Time;Tissues;tool;Trauma;traumatic event;Veterans;wound

PROJECT_TITLE: Autonomic Regulation of the Immunological Response to Limb Injury

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The Next-Gen Oncopathology (NGO) Program will provide trainees in pathology an opportunity to conduct cancer research and train in cutting-edge methodologies relevant for cancer understanding and precision diagnosis. Our goal is to prepare young pathologists to lead and drive innovations in laboratory cancer diagnosis into the future.

PI_NAMEs: CESARMAN, ETHEL  (contact);KLEAVELAND, BENJAMIN MONTEVERDE

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: programs

PROJECT_TITLE: Next-Gen Oncopathology Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NASHVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE To enhance the diversity of the virology workforce and fully address the problem of health disparities associated with viral diseases, the number of underrepresented minority (URM) students must be increased. The proposed “Enhancing Virology Training (ENVIT) through Summer Research” program is a 10-week intensive, virology- focused research experience that will expose graduate, medical and dental students to the broader area of virology. It will provide participants with a better understanding of how biomedical, behavioral and clinical research influences the field of virology and will inspire participants to pursue careers in virology research.

PI_NAMEs: DASH, CHANDRAVANU  (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Acute;Address;Affect;African American population;Area;Basic Science;Behavioral Research;Biomedical Research;career;Career Choice;career development;Caring;Clinical;Clinical Research;Clinical Trials;collaborative environment;combat;Communicable Diseases;Communication;Communities;County;COVID-19;COVID-19 pandemic;COVID-19 testing;COVID-19 vaccine;Creativeness;Dental Students;Disease;Diverse Workforce;Ebola;Education;Educational process of instructing;Environment;Evaluation Research;evidence base;experience;Faculty;faculty mentor;fighting;First Generation College Students;Fostering;Funding Agency;Goals;Government;graduate student;hands on research;Health;Health Disparities Research;health disparity;Hispanic Populations;Historically Black Colleges and Universities;HIV;Human;Immunity;improved;Infection;Inflammation;Influenza;Institution;interest;International;Laboratories;laboratory experience;Leadership;Learning Skill;lectures;medical schools;Medical Students;member;Mentors;Mentorship;Methods;Minority Groups;minority health;Minority-Serving Institution;National Institute of Allergy and Infectious Disease;next generation;operation;Oral;Participant;pathogen;pathogenic virus;peer;Play;Positioning Attribute;Postdoctoral Fellow;posters;prevent;Problem Solving;programs;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Technics;Research Training;Role;role model;Science;Site;skill acquisition;skills;Strategic Planning;student training;Students;summer research;symposium;Tennessee;Training;Training and Education;Training Programs;Translational Research;Underrepresented Minority;underrepresented minority student;virology;Virus;Virus Diseases;Work;Writing

PROJECT_TITLE: Enhancing Virology Training of Underrepresented Minority Students through Summer Research


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Estrogen;HIV/AIDS;Infectious Diseases;Menopause;Neurosciences;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Women living with HIV (WLH) are at a disadvantage in that they are more likely to experience menopause at an earlier age in addition to their biological sex increasing their likelihood of developing cognitive impairment. Because evidence has implicated estrogens as neuroprotective mediators for cognitive health, this proposal aims to investigate the role of estrogen receptors in mediating cognitive decline in WLH, utilizing menopausal status along with age to account for different stages of the aging process. Resulting data may point towards utilizing estrogen receptor levels in peripheral blood mononuclear cells (PBMCs) as a biomarker for identifying WLH who are at a higher risk for developing cognitive deficits.

PI_NAMEs: TURKSON, SUSIE ANNMARIE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Address;Affect;Age;Aging;aging process;Alzheimer's Disease;Animal Model;Anti-Inflammatory Agents;Biological Assay;Biological Markers;biological sex;biomarker selection;Biometry;C-reactive protein;Cells;Cellular biology;Central Nervous System;Clinical;Cognition;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cognitive performance;cognitive task;cohort;Cohort Studies;Coupled;cytokine;Cytokine Gene;Data;data repository;Dementia;design;Development;Disadvantaged;Doctor of Philosophy;early experience;early onset;ESR1 gene;Estradiol;Estrogen decline;Estrogen deficiency;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Evaluation;experience;Female;Future;Gene Expression;General Population;Genes;Goals;Health;high risk;Highly Active Antiretroviral Therapy;HIV;HIV diagnosis;HIV Seropositivity;Hormones;Human;Immune;Immune response;Immune system;Immunoglobulin Genes;immunoregulation;Impaired cognition;Inflammaging;Inflammation;Inflammatory;insight;Interferon Type II;Interleukin-1 beta;Interleukin-12;Interleukin-6;Investigation;Link;male;Mediating;Mediator;Memory;men;Menopausal Status;Menopause;Mental Health;Molecular;Molecular Biology;molecular subtypes;Nature;Neuroendocrinology;neuroinflammation;neuroprotection;older adult;Outcome;Participant;Pathogenesis;Performance;Peripheral Blood Mononuclear Cell;Persons;Physicians;Population;Postmenopause;Predisposition;Premature Menopause;Premenopause;Process;protein expression;receptor;receptor expression;receptor function;Receptor Gene;Recording of previous events;Research;Risk;Risk Assessment;Risk Reduction;Role;Sampling;Scientist;screening;Single Nucleotide Polymorphism;skills;substance use;synaptic function;systemic inflammatory response;Testing;Time;TNF gene;Toll-like receptors;Training;Translating;Treatment Protocols;Universities;Virginia;Western Blotting;Woman;Women's Interagency HIV Study

PROJECT_TITLE: Women Living with HIV: Cognitive Impact of Estrogen Receptors, Inflammation, and Aging


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The Pde6cfloxSTOPN/Arr3CreERT2 and Gnat2floxSTOPN/Arr3CreERT2 programmable preclinical models will provide a platform on which to test ongoing research studies aimed at increasing restoration of visual function following gene therapy for cone-mediated dystroph.

PI_NAMEs: TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Adult;aerobic glycolysis;Affect;Age;Alleles;alpha Subunit Transducin;Amblyopia;American;anaerobic glycolysis;arrestin3;Behavior;brain circuitry;Cessation of life;Clinical;Clinical Trials;clinically relevant;clinically significant;Cone;Cone dystrophy;Cre driver;critical period;cyclic nucleotide-gated cation channel;Degenerative Disorder;Development;Diagnosis;Disease;DNA cassette;effective therapy;Engineering;Enrollment;Functional disorder;Funding;gene therapy;Gene therapy trial;Genes;Genetic;Genotype;Goals;GTP-Binding Proteins;guanine nucleotide binding protein;Human;improved;inducible Cre;Interruption;Intervention;LoxP-flanked allele;Mediating;Metabolic;Modeling;mouse model;Mus;Mutation;novel;Nuclear;Onset of illness;Pathologic;Pathway interactions;Patients;Phenotype;phosphodiesterase 6;phosphoric diester hydrolase;photoreceptor degeneration;Photoreceptors;Pre-Clinical Model;preservation;Production;promoter;Protocols documentation;research study;resilience;restoration;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Rod;synaptogenesis;System;Tamoxifen;Testing;Therapeutic;Therapeutic Intervention;Time;Translating;Vertebrate Photoreceptors;Viral Vector;Vision;Visual;visual dysfunction;visual threshold

PROJECT_TITLE: Defining Barriers to Gene Therapy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Peripheral artery disease (PAD) is a major cause of loss of limbs. While interventional devices such as drug- coated balloons (DCBs) are effective at treating PAD, recent studies suggest the potential for DCBs to cause harm, and the use of current generation DCBs has been markedly reduced. In this proposal, we will engineer next generation DCBs with improved efficacy and safety profiles to help restore DCB treatment options for patients with PAD.

PI_NAMEs: KOLACHALAMA, VIJAYA B. (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acute;aging population;Angioplasty;Arterial Fatty Streak;Arteries;Atherosclerosis;Balloon Angioplasty;biomaterial compatibility;biophysical model;Biophysics;Catheters;Chemicals;Clinical;Clinical effectiveness;clinical translation;Communities;coronary vasculature;critical limb Ischemia;Data;Death Rate;design;Device Designs;Devices;Dexamethasone;Drug Delivery Systems;Drug Kinetics;Drug Modelings;Drug Modulation;drug release kinetics;Drug usage;Drug Utilization;Emerging Technologies;Engineering;Environmental Risk Factor;Excipients;experience;FDA approved;Fluorescence;follow-up;Formulation;Fracture;Future;Generations;Goals;high risk;hydrophilicity;Implant;improved;in vivo;in vivo Model;Inflammation;insight;interfacial;Intervention;Lead;Lesion;limb amputation;limb loss;Link;Measures;mechanical force;Mechanics;Meta-Analysis;Metals;Modeling;Modification;Molecular;Morphology;mortality;next generation;novel;novel drug class;novel therapeutics;Optical Coherence Tomography;Oryctolagus cuniculus;Outcome;Ozone;Paclitaxel;Patients;Performance;Peripheral arterial disease;Permeability;Pharmaceutical Preparations;Physicians;Physiological;pre-clinical;preclinical development;predictive modeling;Prevalence;Property;Publications;Publishing;randomized trial;Randomized, Controlled Trials;response;restenosis;Role;Safety;standard of care;Stents;structural imaging;Structure;Surface;systemic toxicity;Technology;Testing;Tissues;Treatment Protocols;ultrasound;United States;uptake;Urea;Work

PROJECT_TITLE: Mechanisms of drug-coated balloon therapy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN JOSE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE STATEMENT Asian/Asian American immigrant young adults learn multiple languages, being exposed to English as an additional language (L2) in the U.S. after mainly using a first language (L1) from their country of origin. In this grant, we propose to investigate the impact of learning an additional language, namely, the dominant language of the community, on Asian/Asian American immigrant young adults' mental health and psychological well-being as well as their sense of acceptance, inclusion, and ethnic identity in the U.S. Our study will provide suggestions to address the structural drivers of mental health disparities among immigrant populations, such as results of the experience of racism and discrimination, which are linked to individual's own multilingual language identity and skills.

PI_NAMEs: PARK, CHULWOO  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acculturation;Address;Adjustment Disorders;Adolescent;Age;aged;American;anti-Asian;Anxiety;Area;Asian;Asian Americans;Attention;California;Child;Communities;Competence;Confusion;Country;COVID-19 pandemic;Data;design;Development;Discrimination;English Language;ethnic identity;Ethnic Population;experience;Exposure to;Focus Groups;Foundations;Friends;Generations;graduate student;Grant;hate crimes;health disparity;health disparity populations;health equity;health goals;Home;Immigrant;Immigration;Individual;instrument;Interdisciplinary Study;Intervention;intervention program;Interview;Language;Language Development;language perception;Learning;Link;marginalization;Measures;Mediating;Mental Depression;Mental Health;Mental Health Associations;Methods;Migrant;migration;Moods;Multilingualism;Neighborhoods;Outcome;Parents;Participant;Pathway interactions;Patient Self-Report;Population;Post-Traumatic Stress Disorders;Prevention program;Productivity;psychosocial;psychotic;Public Health;public health relevance;racial population;racism;Reduce health disparities;Reporting;Research;Research Design;Research Methodology;Sample Size;San Francisco;Schools;Science;Shapes;skills;social culture;social health determinants;Socialization;Societies;socioeconomics;Stress;Suggestion;Surveys;Target Populations;Time;undergraduate student;United States;Well in self;Work;young adult

PROJECT_TITLE: Language Identity and Mental Health Disparities among Multilingual 1.5 Generation Asian/Asian American Immigrant Young Adults: A Mixed Methods Study


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Sleep Research;Telehealth

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative This K01 award is predicated upon the compelling data to show that transportation workers are at risk for obstructive sleep apnea (OSA), yet report abysmal rates of OSA evaluation and treatment. The work proposed in this award will design a tailored text messaging intervention to address unique barriers and facilitators to OSA evaluation and treatment reported among transportation workers. This study will provide the necessary data for a planned R01 submission and launch the Candidate as a leader in novel behavioral interventions to improve sleep disorders awareness, evaluation, and long-term treatment adherence.

PI_NAMEs: ROBBINS, REBECCA  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Accidents;adaptive intervention;Address;Adherence;Agreement;apprenticeship;Area;Award;Awareness;Behavior;behavior test;Behavior Therapy;Behavioral;Belief;Biometry;Caliber;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Caring;Cellular Phone;Clinical Trials;Clinical Trials Design;cognitive interview;Consultations;Control Groups;Data;design;Development;Diagnosis;Ecological momentary assessment;Education;effectiveness evaluation;Environment;Evaluation;Excessive Daytime Sleepiness;experience;Exposure to;Focus Groups;Funding;Future;Goals;Health;health communication;Heart failure;Hypertension;improved;improvement on sleep;Individual;Injury;Ink;innovation;Intervention;Job loss;Link;Maintenance;Mediating;medical schools;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;mHealth;mhealth interventions;Monitor;Myocardial Infarction;novel;Obstructive Sleep Apnea;Operative Surgical Procedures;Oral Positive Airway Pressure;Participant;Phase;Pilot Projects;pilot test;Population;Positioning Attribute;post-doctoral training;programs;prototype;Public Health;Questionnaires;Random Allocation;Randomized;Readiness;Recommendation;Reporting;Research;Research Personnel;Risk;Scientist;Self Efficacy;Series;Sleep;Sleep Disorders;social cognitive theory;Stroke;Surveys;tailored messaging;tailored text messaging;Techniques;Text Messaging;text messaging intervention;theories;therapy design;Training;Training and Education;Transportation;treatment adherence;treatment comparison;United States National Institutes of Health;Universities;vehicular accident;Work;Workplace

PROJECT_TITLE: An mHealth intervention to deliver personalized messages to increase adherence to OSA evaluation and treatment among transportation workers

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Cancer;Data Science

ORG_CITY: SEATTLE

ORG_NAME: SAGE BIONETWORKS

ORG_STATE: WA

PHR: Project Narrative Advancing our understanding of cancer requires teams of scientists working together, but many labs and resources remain siloed. The proposed MC2 Center will catalyze collaboration, improve the usability of shared data and tools, and ensure wide dissemination of resources to the broader cancer research community. The resulting collaborative network of diverse researchers will power the next generation of cancer discoveries and treatments.

PI_NAMEs: BANERJEE, JINETA ;VARMA, SUSHEEL  (contact)

PROGRAM_OFFICER_NAME: TURNER, MICHELLE C

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Basic Cancer Research;Benchmarking;Biomedical Research;Cancer Biology;Cancer Center;Collaborations;Communication;Communities;community building;community engagement;Data;Data Commons;data harmonization;data sharing;Deposition;diversity and inclusion;Division of Cancer Biology;Education and Outreach;Educational workshop;Effectiveness;Ensure;Evaluation;evidence base;experience;FAIR principles;Fostering;Funding;Glues;Hybrids;ideation;improved;informatics infrastructure;innovation;interdisciplinary approach;interdisciplinary collaboration;interoperability;Knowledge;Knowledge Portal;Malignant Neoplasms;meetings;Metadata;metadata standards;Modeling;next generation;Outcomes Research;outreach;Persons;programs;public repository;Qualifying;Research Personnel;Resource Sharing;Resources;Science;Scientist;Software Tools;special interest group;success;System;Systems Biology;tool;Training;translational cancer research;usability;Validation;Work;working group

PROJECT_TITLE: Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative We propose to quantitatively describe the bacterial function and host immune response from pre-detection to treatment and post-treatment of urethral and rectal sexually transmitted infections (STI) among men who have sex with men (MSM), and how microbiome composition and function contribute to the high incidence of STIs among MSM. In addition, we will also test the hypothesis that inflammatory microbiota may undermine adaptive immune responses to bacterial STIs that are the objective of prophylactic vaccines. This integrated approach is necessary to identify therapeutic modalities and develop intervention approaches in a way that is optimized for the biological risk context.

PI_NAMEs: MCKINNON, LYLE ;MEHTA, SUPRIYA DINESH (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accounting;adaptive immune response;adaptive immunity;Adjuvant Therapy;Africa South of the Sahara;Aftercare;Anti-Inflammatory Agents;Antibiotic Therapy;Antibody Response;antigen-specific T cells;B-Lymphocytes;bacterial community;behavioral study;Biological;Biological Assay;Biological Response Modifier Therapy;chemokine;Chlamydia trachomatis;Climate;Clinical;Clonality;cohort;complex data;Country;cytokine;Data;design;Detection;Diagnostic;Disease Progression;effective therapy;Epithelium;follow-up;Frequencies;gut inflammation;gut microbiota;Heterosexuals;High Prevalence;HIV;host microbiome;Hot Spot;Immune;immune activation;Immune response;Immunity;Immunologic Factors;Immunologics;Immunology;immunoregulation;Incidence;Infection;Infection Control;Inflammation;Inflammatory;Integration Host Factors;Interferons;Intervention;Investigation;Kenya;Link;longitudinal analysis;Lymphocyte;male;Measures;Mediating;Memory;memory CD4 T lymphocyte;men;men who have sex with men;metagenomic sequencing;Methods;microbiome;microbiome composition;microbiota;Modality;morphogens;Mucous Membrane;Neisseria gonorrhoeae;novel;Nucleic Acids;Outcome;pathogen;Pathway interactions;peer;penile microbiome;Persons;Phenotype;Politics;Population;Prevalence;prevent;Prevention;Preventive;Preventive vaccine;Prevotella;Production;protective efficacy;Recording of previous events;recruit;rectal microbiome;Rectum;response;Risk;Sampling;secondary outcome;Severity of illness;Sexually Transmitted Diseases;Shotguns;Social Behavior;structural determinants;Structure;systemic inflammatory response;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;Urethra;vaccine development;vaccine efficacy;vaccine strategy;vaccine-induced immunity;Vaccines

PROJECT_TITLE: The Clinical History of Rectal and Urethral STIs among MSM: characterizing microbiome host immune interactions for diagnostic and vaccine advances


PHR: About 30% of Veterans who served in the 1990-91 Persian Gulf War are suffering from Gulf War Veterans’ Illness (GWVI), a chronic condition that is still not well understood and for which adequate treatment is lacking. GWVI is manifested by multiple chronic symptoms, including pain, sleep, neurological, gastrointestinal, respiratory, and skin problems. Recent evidence suggests that the brainstem is selectively damaged in GWVI. Novel brain imaging techniques enable us now to objectively measure this damage and to relate it to GWVI symptoms. We propose to investigate the role of the brainstem in regulating pain and sleep in GWI using advanced brain imaging and psychophysical measurements. The findings from this project have great potential for the development and refinement of novel therapeutic approaches using drugs, psychotherapy or neurostimulation to target and augment descending modulation pathways.

PI_NAMEs: FURST, ANSGAR J. (contact)

PROJECT_TERMS: Affect;Area;Atrophic;Brain imaging;Brain Stem;burn pit;Cell Nucleus;Chemicals;Chronic;Cognitive;conditioned pain modulation;Consent;Development;diagnostic criteria;Dorsal;Drug usage;efficacy evaluation;Eligibility Determination;Fiber;gastrointestinal;Gulf War;Gulf War veteran;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Imaging Techniques;Infectious Agent;interest;Intervention;Link;locus ceruleus structure;Magnetic Resonance Imaging;Measurement;Measures;Mefloquine;midbrain central gray substance;neuroimaging;Neurologic;novel;novel therapeutic intervention;novel therapeutics;Observational Study;Organophosphates;Outcome Measure;Pain;pain processing;pain reduction;pain signal;Participant;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Persian Gulf;Persian Gulf Syndrome;persistent symptom;Probability;Process;Psychophysics;Psychotherapy;pyridostigmine;Reporting;Research;Research Design;respiratory;Role;screening;Severities;Skin;Sleep;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Stimulus;Stress;Structure;symptomatology;Symptoms;Testing;Therapeutic Trials;Time;Tissues;Toxic effect;Translations;Veterans;Visit;white matter

PROJECT_TITLE: The role of the brain stem in GWVI pathology


ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: Obesity increases the risk of developing type 2 diabetes. Over 35 percent of veterans are obese and many veterans are morbidly obese. Thromboxanes are fatty acid metabolites which are known to mediate inflammation by binding with a protein called thromboxane-prostanoid receptor (TP-R). Our preclinical studies show that mice lacking TP-R gene gained less body weight, and showed improvements in glucose handling on a high fat diet. Our data also show that markers of amino acid metabolism, in particular, histidine metabolism, are dramatically increased in the adipose tissue. Therefore, we hypothesize that blocking TP-R activation may be helpful to promote histidine metabolism in adipose tissue which, in turn, can improve systemic glucose homeostasis in obesity. This proposal involves collaboration between Dr. Viswanathan, a basic scientist and Dr. Desouza, a clinical investigator. The proposed studies will lead to development of a novel drugs to manage obesity and/or type 2 diabetes in VA and general population.

PI_NAMEs: DESOUZA, CYRUS V;VISWANATHAN, SARASWATHI  (contact)

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;Affect;Amidohydrolases;amino acid metabolism;Amino Acids;Anti-Inflammatory Agents;Arachidonic Acids;Binding;Biochemical;Biological;blood glucose regulation;Body Weight;Branched-Chain Amino Acids;Case/Control Studies;Catabolism;Cell Line;Cells;Clinical;Clinical Investigator;Clinical Research;Collaborations;Collecting Cell;comparison control;Correlation Studies;Data;Development;Diet;diet-induced obesity;Enzymes;Essential Amino Acids;experimental study;Exposure to;Fatty Acids;Future;General Population;Genes;Glucose;glucose metabolism;glucose uptake;Hemostatic function;High Fat Diet;Histidine;Histidine Ammonia-Lyase;Histidine Metabolism Pathway;Human;Hyperglycemia;IL8 gene;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Link;lipid mediator;Measures;Mediating;Mediator;member;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;Metabolism;Mission;Molecular;Morbid Obesity;mouse model;mRNA Expression;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;obese patients;obese person;Obesity;Obesity associated disease;obesity management;Operative Surgical Procedures;Overweight;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma;Play;preclinical study;Process;Prostaglandins;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;receptor;Receptor Activation;receptor expression;Receptor Gene;Regulation;Research;Risk;Risk Factors;Role;Scientist;Signal Transduction;small molecule inhibitor;Stimulus;subcutaneous;Supplementation;targeted treatment;Therapeutic;therapeutic target;Thinness;Thromboxane A2;Thromboxanes;translational study;Triglycerides;uptake;vasoconstriction;Veterans;Visceral

PROJECT_TITLE: TP-R: a novel mediator of obesity-linked insulin resistance in humans


ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Our data suggests that treatment with LKE or derivatives will accelerate remyelination in mouse models of MS, and will be of direct value to Veterans who suffer from MS (or other demyelinating diseases). MS is the most common neurodegenerative disease in adults, nearly 50,000 veterans are estimated to have MS with approximately 30,000 veterans currently being treated in the VA health care system. Although the prevalence of MS in Veterans is similar to the general population, the increase in women Veterans will lead to an increase in Veterans with MS since MS is 3-fold more prevalent in women. The proposed work directly addresses RR&D priority areas, to restore structure (myelin) and function (nerve conductance, motor and behavior deficits) which will increase quality of life. It aligns with RR&D priorities of advancing rehabilitative care of Veterans suffering from spinal cord or nerve injuries (in this case due to MS disease), to enhance regeneration and restoration of motor and sensory function; and to treat neurodegenerative disorders.

PI_NAMEs: FEINSTEIN, DOUGLAS L. (contact)

PROJECT_TERMS: Acceleration;Action Potentials;Address;Adult;Amino Acids;Anxiety;Area;Axon;axon injury;Behavior;Behavioral;Brain Stem;Calcium;Cell Differentiation process;Cell Maturation;Cell Membrane Permeability;Chemicals;Chronic;Clinical;collapsin response mediator protein-2;conditional knockout;Confocal Microscopy;Corpus Callosum;Cuprizone;Cyclization;Data;Demyelinating Diseases;Demyelinations;Disease;Disease Progression;dosage;Electron Microscopy;Electrophysiology (science);Equilibrium;Esters;Experimental Autoimmune Encephalomyelitis;experimental study;FDA approved;fluid percussion injury;functional outcomes;functional restoration;General Population;Genes;Goals;gray matter;Healthcare Systems;Image;Immune system;Immune Targeting;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Ion Channel;Ischemia;Knockout Mice;lanthionine;Lead;Lesion;Locomotor Recovery;Lymphocyte;Mediating;Memory;Metabolic;Methods;Modeling;Motor;motor deficit;mouse model;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Myelin;Myelin Sheath;N-Methyl-D-Aspartate Receptors;Natural regeneration;Nerve;nerve injury;Neural Conduction;Neurites;Neurodegenerative Disorders;Neuroglia;Neurological outcome;Neurons;neuroprotection;neurotoxicity;Nitric Oxide;novel;object recognition;oligodendrocyte progenitor;oligodendrocyte-myelin glycoprotein;Oligodendroglia;Optic Nerve;Parents;Peptides;Peripheral;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Phosphorylation;Prevalence;Production;Property;Quality of life;Ranvier's Nodes;Rattus;Regenerative capacity;rehabilitative care;remyelinating agent;remyelination;restoration;screening;Sensory;Spinal Cord;Spinal cord injury;Spinal nerve structure;stem cells;Structure;Symptoms;Testing;Thick;Thinness;trend;Veterans;voltage;Woman;Women's prevalence;Work

PROJECT_TITLE: Accelerating remyelination using lanthionine ketimine derivatives

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Biofilm formation, a crucial bacterial lifestyle for persistence in particular niches, tolerance to antimicrobials and virulence in many pathogens, is governed by environmental and self-generated stimuli. How the information encoded in multiple sensory inputs is extracted and integrated to control biofilm development is poorly understood. Using the multi-drug resistant human pathogen Pseudomonas aeruginosa as model system, the proposed research will investigate how light, nutrients and population-density signals, individually and in combination, control biofilm development.

PI_NAMEs: MUKHERJEE, SAMPRITI  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: 3-Dimensional;anti-microbial tolerance;Architecture;Bacteria;bacterial genetics;Basic Science;Behavior;Biochemistry;Biological;Biological Models;Chemicals;clinically relevant;Communities;Cues;Decision Making;design;detection of nutrient;Development;Environment;Fluorescence Microscopy;genome-wide;Goals;human pathogen;Individual;interdisciplinary approach;Knowledge;Learning;Life Style;Light;mathematical model;Mediating;Microbial Biofilms;Molecular;Molecular Biology;Multi-Drug Resistance;multidrug-resistant Pseudomonas aeruginosa;multiple drug use;novel therapeutic intervention;Nutrient;Nutrient availability;Organism;pathogen;Pathway interactions;Photoreceptors;Population Density;Process;programs;Pseudomonas aeruginosa;quorum sensing;Regulation;Repression;Research;response;Role;Sensory;sensory input;sensory integration;Signal Pathway;Signal Transduction;Stimulus;structural biology;Structure;System;Virulence;Work

PROJECT_TITLE: Probing the role of sensory cues in the regulation of bacterial biofilm development

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative: This multi-project program will develop medical treatments for people exposed to radiation.

PI_NAMEs: CHAO, NELSON J. (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Academic Medical Centers;Accidents;Acute;Address;Animal Model;Applied Research;Area;Basic Science;Biology;cancer therapy;Centers of Research Excellence;Dedications;Development;driving force;Education;Exposure to;extracellular vesicles;Fertilization;Fostering;Funding;gastrointestinal system;Gastrointestinal tract structure;Goals;gut microbiome;Health Physics;Hematopoietic;Hour;Human;Immunology;in vitro Assay;Individual;Injury;injury and repair;Innate Immune Response;innovative technologies;inter-institutional;Interdisciplinary Study;irradiation;Knowledge;Lead;Medical;Medical center;medical countermeasure;member;Myelogenous;Normal tissue morphology;North Carolina;novel;novel therapeutics;Nuclear;Nuclear Warfare;Persons;Phosphotransferases;Physics;Population;predictive modeling;prevent;programs;Radiation;radiation countermeasure;Radiation Dose Unit;radiation effect;Radiation induced damage;Radiation Injuries;radiation-induced injury;Radioactive;Radiobiology;radiological attack;radiological weapon;Radiology Specialty;Research;research and development;Research Personnel;Research Project Grants;response;Scientist;Secondary to;Special needs;stem cell biology;Terrorism;Time;tissue injury;Tissues;Toxic effect;trafficking;Training and Education;Translational Research;Transplantation;Universities;War;Work

PROJECT_TITLE: Centers for Medical Countermeasures Against Radiation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures

PROJECT_TERMS: Accounting;Address;Administrative Efficiency;Administrative Supplement;Advisory Committees;Advocate;Budgets;Clinical;Collaborations;Communication;Communication Programs;data exchange;data sharing;Decision Making;Development;effective therapy;Electronic Mail;Ensure;Evaluation;Expenditure;Exposure to;federal policy;Fostering;Funding;Goals;Grant;Human Resources;Institution;Intellectual Property;Ionizing radiation;Laws;Leadership;Maintenance;Malignant Neoplasms;Medical;Medical center;medical countermeasure;meetings;member;Monitor;novel;Occupational activity of managing finances;Patients;Periodicals;Persons;Policies;Private Enterprises;Procedures;Productivity;programs;Radiation;radiation countermeasure;Regulation;Reporting;Research;Research Personnel;Resources;Scientist;Solid;Strategic Planning;success;System;Telephone;timeline;transmission process;trend;United States National Institutes of Health;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer

PHR: Biostatisticians of this core collaborate with the investigators to produce well-designed studies and experiments with clearly defined objectives optimized to address the scientific questions in clinical and translational cancer research and ensure that the resulting data are analyzed rigorously and interpreted appropriately. They provide analysis support of both prospective and retrospective clinical data, and analysis support of both candidate and high throughput genomic data. When existing methods and tools are inadequate to address the scientific questions asked, the biostatisticians will develop requisite methods and tools.

PI_NAMEs: OWZAR, KOUROS  (contact)

PROJECT_TERMS: Address;Adherence;Algorithms;Area;Awareness;Basic Science;Bioinformatics;Biomedical Research;Biometry;Biostatistics Core;candidate marker;Clinical;Clinical Data;Clinical Sciences;Collaborations;Communities;Computer software;computerized tools;Conceptions;Data;Data Collection;Data Provenance;design;Development;Discriminant Analysis;Documentation;Education;Ensure;experience;Experimental Designs;experimental study;Faculty;Flow Cytometry;genomic data;Grant;Human Resources;improved;Information Dissemination;Laboratories;Leadership;Licensing;literate;Malignant Neoplasms;Medical center;medical countermeasure;member;Methodology;Methods;Mission;Molecular Analysis;next generation sequencing;novel;Performance;Phase;Procedures;Program Research Project Grants;programs;prospective;Proteomics;Quality Control;Radiation;radiation countermeasure;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Role;Science;scientific computing;skills;sound;Statistical Computing;Statistical Data Interpretation;statistical learning;Statistical Methods;statistics;Technical Expertise;Testing;tool;translational cancer research;Translational Research;Validation

PROJECT_TITLE: Core 1 Biostatistics


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE More than 70% of older adults are overweight or obese and many older obese adults experience exercise intolerance and dyspnea (shortness of breath) on exertion (DOE). We have identified numerous obesity- related effects that could influence exercise tolerance and DOE in younger obese adults; however, it is unclear whether these harmful effects are exaggerated in older obese adults and/or whether they reduce exercise tolerance, provoke DOE, or contribute to respiratory symptoms that could be wrongly diagnosed as exercise deconditioning and/or cardiopulmonary disease. The overall objective of this application is to investigate the effects of obesity on lung function, exercise tolerance, and DOE in older obese adults (65-75 yr.) as compared with older nonobese adults, and the effects of mechanical unloading of the thorax at rest and during exercise using a novel external cuirass (i.e., a plastic shell placed over the thorax).

PI_NAMEs: BABB, TONY G (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Abdomen;Activities of Daily Living;Adult;adult obesity;Affective;age related;age related decline;aged;aging related;Body Weight decreased;Breathing;Caring;Chest;Chest wall structure;Clinical;cost;Coupled;deconditioning;Diagnosis;Dimensions;Dyspnea;Ergometry;Exercise;exercise intolerance;Exercise Tolerance;Exertion;experience;Fatty acid glycerol esters;Functional Residual Capacity;improved;Laboratories;lung volume;mechanical load;Mechanics;Medical Research Council Dyspnea Scale;men;Metabolic;Non obese;novel;Obesity;obesity treatment;older adult;Overweight;overweight adults;Perception;Phase;Physical Fitness;preservation;pressure;Prevention;pulmonary function;Pulmonary Heart Disease;Quality of life;research clinical testing;Respiration;respiratory;respiratory examination;Respiratory Mechanics;Respiratory physiology;Respiratory Signs and Symptoms;Rest;rib bone structure;Risk;Sensory;Shortness of Breath;Supination;Testing;Time;treatment strategy;unnecessary treatment;ventilation;Woman;Work of Breathing

PROJECT_TITLE: Effects of Obesity in the Aged

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PHR: Narrative  The RadCCORE Immune Core (Core 2) will provide high-quality, polychromatic immunophenotyping and cell  sorting, multiplex cytokine profiling, and molecular monitoring of T cell repertoire and thymic recovery.  Comprehensive and centralized immune monitoring adds significant value to all RadCCORE studies, and will  allow project investigators to better, and more efficiently, develop the next generation of radiation  countermeasures.

PI_NAMEs: MACINTYRE, ANDREW  (contact)

PROJECT_TERMS: Award;beta Chain Antigen T Cell Receptor;biocontainment facility;Biological;Biological Assay;Biological Markers;Budgets;Cell Separation;Cells;Charge;chemokine;Collaborations;Color;cytokine;deep sequencing;Development;Excision;Flow Cytometry;Fluorescence-Activated Cell Sorting;Future;Gene Expression Profiling;Genes;Goals;Hormones;Human;Immune;immune reconstitution;Immunologic Monitoring;Immunology;Immunophenotyping;innovation;instrument;instrumentation;Legal patent;Lung Lavage Fluid;Medical center;medical countermeasure;Molecular;Monitor;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;Peripheral;Phenotype;Plasma;Procedures;programs;Protein Array;Proteins;Protocols documentation;Quality Control;Radiation;radiation countermeasure;Reader;Reagent;Records;Recovery;Research Personnel;Resource Sharing;Sampling;Schedule;Serum;Services;Signal Transduction;Sorting;Speed;Surface;T-Cell Receptor;T-Lymphocyte;Technology;Thymus Gland;Time;tissue culture;Update;Vaccines;web app;Work

PROJECT_TITLE: Core 2 Immune Monitoring


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Genetics;Physical Injury - Accidents and Adverse Effects

PHR: Radiation Countermeasures Center of Research Excellence Core 3: Primate Studies Narrative The Primate Studies Core facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates (NHP), following the specific priorities of the RadCCORE consortium and sharing tissue and data with other CMCRs nationwide. Core investigators have substantial experience and expertise studying radiation countermeasures in NHPs. The main core user will be Project 3, FSL-1 as a GI and hematopoietic mitigator, but all Projects will be served.

PI_NAMEs: CLINE, J. MARK (contact)

PROJECT_TERMS: Animals;Antibodies;Autopsy;Biochemistry;Bioinformatics;Biological;Biological Markers;Biostatistics Core;Caring;Cells;cellular development;Centers of Research Excellence;Clinical;clinical care;Clinical Endocrinology;Clinical Management;Clinical Medicine;Clinical Pathology;collaborative approach;Comparative Pathology;cross reactivity;cytokine;Data;data management;data sharing;design;Development;DNA Sequence;Dose;drug development;Epigenetic Process;Evaluation;experience;Funding;Future;Gene Chips;Gene Expression;Genetic;Genetic Databases;Genome;germ free condition;Hematopoietic;Human;Image;Immunologic Monitoring;Intervention;irradiation;Liquid substance;Macaca;Macaca mulatta;Maintenance;Measurement;Medical;Medical center;medical countermeasure;Medicine;Modeling;Molecular;Monkeys;nonhuman primate;novel therapeutics;Outcome;Pathologic;Pathology;pharmacologic;phenotypic biomarker;Physiological;preclinical study;preclinical trial;Primates;Prospective Studies;Publications;Radiation;radiation countermeasure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Physics;radiation response;Reagent;receptor;Regulation;Research Personnel;Resources;Rhesus;Sampling;Services;skills;Techniques;Therapeutic Intervention;Tissue Banks;Tissue Sample;Tissues;Treatment outcome;Whole-Body Irradiation;Work

PROJECT_TITLE: Core 3 Non Human Primate Studies


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: A Convergent Bioengineered Platform for Multifunctional Therapeutic Exosomes Project Narrative: Exosomes are very promising drug delivery vehicles but there remain fundamental challenges to the utilization of exosomes in the clinic, including limited drug loading efficiency, insufficient production of exosomes with multiple abilities for satisfactory disease targeting, tracking and combinational therapies. Our proposed research is set to address these challenges by developing a convergent bioengineered platform for manufacturing and engineering therapeutic exosomes, which will allow the loading of drugs into exosomes with high efficiency, biomanufacturing of exosomes in high throughput, and further engineering exosome-based drug delivery systems for various diseases with desired functions including targeted delivery, tracking, and combinational therapies. The proposed research contains several innovative approaches of exosome production, loading and engineering that, if successful and integrated, will provide a high-throughput and high-efficiency exosome manufacturing platform for drug delivery, and expand exosome-based drug delivery to diverse biomedical and clinic applications by combining the merits of both the native exosomes and synthetic nanoparticles.

PI_NAMEs: WANG, YICHUN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;anticancer activity;Antineoplastic Agents;Biomanufacturing;biomaterial compatibility;Biomedical Engineering;Bioreactors;blood-brain barrier crossing;blood-brain barrier penetration;cancer therapy;Clinic;Clinical;Combined Modality Therapy;comparative efficacy;delivery vehicle;Dendrimers;Development;Diameter;Disease;Drug Delivery Systems;Endowment;engineered exosomes;Engineering;Eukaryotic Cell;exosome;extracellular vesicles;Formulation;Gene Delivery;Goals;graphene;Hybrids;image guided;immunogenicity;improved;in vivo;innovation;Ligands;Liposomes;manufacture;Molecular;nanocarrier;nanofiber;nanoparticle;nanoscale;Natural regeneration;Near-infrared optical imaging;Neoplasm Metastasis;nuclease;nucleic acid-based therapeutics;Nucleic Acids;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Play;Polymers;Production;Property;Proteins;Quantum Dots;Research;RNA;scaffold;System;targeted delivery;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic protein;Tissues;Toxic effect;transcriptomics;uptake

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Hematology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: RELEVANCE We have recently identified CaMKK2 as a novel target to mitigate acute effects of radiation on hematopoietic compartment and shown that when provided IP 24-hours posttotal body irradiation, STO-609, a small molecules CaMKK2 inhibitor increases survival of lethally irradiated mice and enhances hematopoietic stem and progenitor cell (HSPC) recovery following sub-lethal TBI. Our preliminary PK plasma data indicate that STO can be delivered orally, and our ongoing studies are aimed at optimizing formulation and dosing for STO-609 oral delivery. Because the development of a novel medical countermeasure, proposed in this application, is considered time critical in the pursuit of treatment of radiation injuries in the wake of a mass casualty, public health emergency, this funding is considered to be time critical.

PROJECT_TERMS: Acceleration;Acute;animal rule;Behavior;Biological Assay;Body part;Bone Marrow Cells;Brain;Ca(2+)-Calmodulin Dependent Protein Kinase;Calmodulin 1;cell type;Cells;Cessation of life;clinically relevant;Data;Development;Dose;druggable target;energy balance;Enzymes;Epithelial Cells;Epithelium;Event;Exposure to;FDA approved;Formulation;Foundations;Funding;gastrointestinal;Gastrointestinal tract structure;Genetic;Germ Lines;Goals;Grant;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Hour;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory Response;inhibitor;insight;intestinal epithelium;Intestines;Ionizing radiation;irradiation;Knockout Mice;Lethal Dose 50;Macrophage;mass casualty;Medical center;medical countermeasure;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Natural regeneration;novel;Nuclear Accidents;Oral;Organoids;Pain;pharmacologic;Phosphotransferases;Plasma;Play;Proliferating;public health emergency;Publishing;Radiation;radiation effect;Radiation Injuries;radiation mitigation;radiation response;Radiation Tolerance;Radiation Toxicity;radiation-induced injury;radiological attack;Recovery;Resistance;Role;small molecule;small molecule inhibitor;stem cell niche;stem cell proliferation;stem cells;System;Testing;Time;tissue regeneration;tissue stem cells;Tissues;transcriptome;Translating;villin;Whole-Body Irradiation

PROJECT_TITLE: Project 1  CaMKK2 a novel target to mitigate radiation induced injury of the hematopoietic system and the gastrointestinal tract


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Hematology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Radiation exposures from nuclear terrorist attacks or nuclear accidents can cause myelosuppression or death. This project aims to uncover a novel mechanism by which endothelial cells participate in blood stem cell regeneration through cell-to-cell communication via secretion of extracellular vesicles. The proposed research may result in the use of endothelial-cell derived extracellular vesicles as an off-the-shelf therapy for the treatment of myelosuppression that occur following radiation exposures as well as in a wide variety of other clinical settings including chemotherapy and stem cell transplantation.

PI_NAMEs: DOAN, PHUONG LINH (contact)

PROJECT_TERMS: Acceleration;Allogenic;Animals;Biological;Biological Assay;Bone Marrow;Cell Communication;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;Clinical Research;Communication;comparison control;Cryopreservation;cytokine;Data;Development;Devices;Disasters;Dose;Endothelial Cells;Endothelium;Engraftment;exosome;Extracellular Matrix;extracellular vesicles;Family;Future;gastrointestinal;Gastrointestinal Injury;gastrointestinal system;Goals;Granulocyte Colony-Stimulating Factor;Hematology;Hematopoietic;Hematopoietic Cell Growth Factors;Hematopoietic stem cells;Hematopoietic System;Hemorrhage;Homing;Hour;Human;IL3 Gene;Immune Tolerance;Infection;Intestines;Ionizing radiation;irradiation;Life;Marrow;mass casualty;Mass Spectrum Analysis;Measures;Mediating;Medical center;medical countermeasure;microvesicles;mouse model;Mus;Myelosuppression;Natural regeneration;novel;Nuclear;Nuclear Accidents;Nucleic Acids;Organ;Organoids;permissiveness;Pharmaceutical Preparations;Physiological;Protein Analysis;Protein Family;Protein Secretion;Proteins;Public Health;Publications;Radiation;Radiation exposure;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Protection;radiation response;Radiation therapy;Radiation Toxicity;Recombinant Proteins;Recovery;Refractory;regenerative;Regenerative capacity;repaired;Research;response;Risk;Schedule;Signal Transduction;Source;stem cell expansion;stem cell self renewal;Stem cell transplant;Terrorism;Testing;Tissue Inhibitor of Metalloproteinases;translational applications;Transplantation;Umbilical Cord Blood;Vascular Endothelial Cell;weapons

PROJECT_TITLE: Project 2 Endothelial Cell-Derived Extracellular Vesicles for Mitigation of the Hematopoietic Acute Radiation Syndrome


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Infectious Diseases;Microbiome;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: UNC-CH SUBCONTRACT Narrative This application focuses on a central goal of the RFA for Centers for Medical Countermeasures Against Radiation by developing an existing, experimental radio-mitigator and by discovering new therapies to minimize radiation induced damage and to enhance survival.

PI_NAMEs: TING, JENNY P (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;adaptive immunity;Age;Animal Model;Animals;Bacteria;Bacteroides;Binding;Biodistribution;Blood;Blood Platelets;Cardiotoxicity;Cell Line;Cells;cerebrovascular;Cessation of life;commensal bacteria;commensal microbes;Cutaneous;Data;Development;Disease;Dose;Drug Kinetics;Environment;Epithelial Cells;experimental study;extracellular;Extravasation;Family;fecal transplantation;feeding;Fibrosis;Functional disorder;Funding;gastrointestinal;Gastrointestinal tract structure;germ free condition;Germ-Free;Goals;Grant;Hematopoietic;Hematopoietic System;House mice;Immune;Immunity;Immunologic Receptors;improved;Infection;Inflammatory;Injury;Innate Immune System;Ionizing radiation;irradiation;life span;Ligands;Link;Lung;Macaca mulatta;Medical center;medical countermeasure;Membrane;Metabolic Pathway;metabolome;metabolomics;Microbe;microbial;microbiota;Monitor;mortality;Mus;Myeloid Cells;Natural Immunity;nonhuman primate;novel therapeutics;Organ;Outcome;pathogen;pathogenic microbe;Pathway interactions;Patients;Pattern recognition receptor;Phase;phosphoproteomics;Physiological;Play;prevent;Prevention;Probiotics;Process;Proteomics;Radiation;radiation countermeasure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Protection;Radiation Toxicity;radiation-induced injury;receptor;Recovery;Role;Sepsis;Source;Survivors;Syndrome;Testing;Tissues;TLR2 gene;Toll-like receptors;Toxic effect;transplant survivor;Universities;Whole-Body Irradiation;Wild Type Mouse;Work

PROJECT_TITLE: Project 3  Innate immune receptor ligand and the microbiota as countermeasures for radiation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Relevance Statement The proposed research is relevant to public health because (1) it aims to develop novel countermeasures against radiation with efficacy at 24 hours after radiation exposure and (2) it aims to define the mechanisms of action of the countermeasures which would provide data necessary for FDA approval of a drug according to the Animal Rule. Therefore, this research has the potential to lead to the approval of a new mitigator of the acute radiation syndrome, which is relevant to the part of the National Institute of Allergy and Infectious Disease’s mission to support research that develops countermeasures against radiation injury.

PI_NAMEs: KIRSCH, DAVID GUY (contact)

PROJECT_TERMS: Abdomen;animal rule;base;Bone Marrow;Cell Cycle;Cell Death;cell injury;Cell Physiology;cell regeneration;cell type;Cells;Columnar Cell;Coupled;CRISPR screen;Data;Development;Dose;drug candidate;Epithelial Cells;epithelium regeneration;Event;Exposure to;FDA approved;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;Genetic;Genetically Engineered Mouse;Goals;Hematopoietic;Hematopoietic System;Homeostasis;Hour;Human;improved;In Vitro;in vivo;inhibitor;Injury;intestinal epithelium;Intestines;irradiation;LGR5 gene;Life;Maintenance;Mediating;Medical center;medical countermeasure;Methods;Mission;Mitosis;Mitotic;Molecular Chaperones;Mucous Membrane;multipotent cell;Mus;National Institute of Allergy and Infectious Disease;Natural regeneration;new therapeutic target;novel;oncoprotein p21;Organ;Organoids;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;Population;preservation;prevent;Proliferating;Protein-Serine-Threonine Kinases;Proteins;Public Health;Publishing;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation induced damage;Radiation Injuries;radiation mitigation;Radiation Toxicity;radiological attack;Radiology Specialty;radioresistant;receptor;Recovery;regeneration following injury;Regenerative capacity;Regulation;Research;Research Support;response;Risk;Role;Secretory Cell;Sensory;Sepsis;Serine;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Intestines;small molecule;stem cell niche;stem cells;sulfated glycoprotein 2;Supporting Cell;Syndrome;Technology;Terrorism;Testing;Threonine;tissue regeneration;Tissues;Toxic effect;TP53 gene;Whole-Body Irradiation;Work

PROJECT_TITLE: Project 4  Dissecting the Role of Revival Stem Cells and Tuft Cells in the Radiation-Induced Gastrointestinal Syndrome to Define Targets for Mitigation


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The inevitable rise of drug-resistant malaria parasites creates a continuing need to develop new control strategies. Our research exploits the finding that malaria parasites depend on the host for an important enzyme cofactor. Understanding how the parasites obtain this cofactor and what they use it for will expose vulnerable aspects of parasite biology that could serve as avenues for new therapeutic interventions.

PI_NAMEs: LLINAS, MANUEL ;PRIGGE, SEAN TAYLOR (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Abbreviations;Acetyl Coenzyme A;Acyl Carrier Protein;Adopted;Amino Acids;asexual;auxotrophy;Biochemical;Biology;Blood;Caprylates;Cells;Cellular biology;Chemicals;Coenzyme A;Coenzymes;cofactor;Data;Development;Drug resistance;Elements;Environment;Enzymes;Erythrocytes;Escherichia coli;Eukaryotic Cell;forging;Genes;genetic approach;Glycine;Goals;Hemagglutinin;Human;insight;Iodoacetamide;Ketoglutarate Dehydrogenase Complex;Life Cycle Stages;Ligase;Ligation;Link;lipoamidase;lipoate;Malaria;Metabolic Pathway;Metabolism;Mitochondria;Mitochondrial Proteins;novel;novel therapeutic intervention;Nuclear;Nutrient;Organelles;orotate;Oxidation-Reduction;Parasites;Pathway interactions;Plasmodium;Plasmodium falciparum;Process;Production;Protein Acetylation;Proteins;Pyrimidine;pyruvate dehydrogenase;Research;Role;Serum;Source;System;transmission process;Tricarboxylic Acids;uptake;Work

PROJECT_TITLE: Cofactor metabolism and mitochondrial function in malaria parasites

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Chicago

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative  We propose to develop a robust methodology for 3D microscopy as a universal tissue assay. This assay will offer high-resolution 3D maps of the transport, distribution, and biological actions of macromolecular drugs in the organ tissue microenvironment of mouse in healthy and disease states. The collection of these maps will generate an atlas of spatial pharmacology of macromolecular drugs in mouse models, which will guide successful preclinical development of macromolecular drugs for a wide range of human diseases.

PI_NAMEs: LEE, STEVE SEUNG-YOUNG (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Atlases;Biological;Biological Assay;Blood;Blood Vessels;Cell Communication;cell type;Cells;Collection;Disease;Goals;human disease;Image;insight;Maps;Methodology;Methods;Microscopy;Molecular;mouse model;Mus;Organ;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;preclinical development;Reference Standards;research and development;Resolution;response;Science;Solid;Specimen;Tissues

PROJECT_TITLE: Integrated three-dimensional (3D) microscopy for a spatial pharmacology atlas of macromolecular drugs in the tissue microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Vaccine Related

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Many children living in rural and resource-limited settings receive delayed or no vaccinations, placing them at risk for potentially dangerous vaccine-preventable diseases. The goal of the proposed research is to evaluate whether an integrated community-based digital health intervention can promote equitable routine vaccinations for children. The study will be conducted in rural Tanzania; however, findings may be broadly relevant for identifying digital health strategies that can be implemented by nursing or other non-physician cadres of health professionals, to bridge vaccination inequities among rural and underserved populations in the United States.

PI_NAMEs: NGADAYA, ESTHER STANSLAUS;OSTERMANN, JAN  (contact);THIELMAN, NATHAN M;VASUDEVAN, LAVANYA

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: 1 year old;acceptability and feasibility;Address;Appointment;Area;caregiver education;Caregivers;Catchment Area;Cellular Phone;Child;Childhood;Collaborations;Communities;Community Health Aides;cost;cost effective;cost effectiveness;Country;COVID-19 pandemic;Dangerousness;Data;digital;digital divide;digital health;digital intervention;Diphtheria;Discipline of Nursing;Disease;economic incentive;Education and Outreach;Educational Intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Elements;Enrollment;Ensure;Equity;Evaluation;financial incentive;Funding;future implementation;Goals;Health;Health behavior;health care delivery;Health care facility;health equity promotion;Health Personnel;Health Professional;Health Services;Health system;Health Technology;Immunization;implementation determinants;implementation evaluation;implementation intervention;implementation outcomes;improved;Incentives;Income;Inequity;Infection;innovation;Interruption;Intervention;Knowledge;Life;Machine Learning;machine learning model;Measles;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute of Nursing Research;Notification;Nurse's Role;outreach;Participant;Performance;Poliomyelitis;predictive modeling;prevent;Prevention;Program Development;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;remote health care;Research;Research Design;Research Priority;research to practice;Residual state;Resource-limited setting;Resources;Risk;Rural;rural area;Rural Health;Rural Population;rural setting;scale up;Side;Speed;supervised learning;System;Tanzania;tool;Training;Translational Research;underserved community;Underserved Population;United States;United States National Institutes of Health;urban area;urban disparity;Vaccinated;Vaccination;vaccination outcome;vaccination strategy;vaccine access;vaccine development;Vaccines;Variant;Woman;Work

PROJECT_TITLE: "Chanjo Kwa Wakati" - Leveraging community health workers and a responsive digital health system to improve vaccination coverage and timeliness in rural settings

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Cancer

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: RELEVANCE TO PUBLIC HEALTH The Stanford Molecular Imaging Scholars (SMIS) program is a unique, integrated, and cross- disciplinary postdoctoral training program that prepares young investigators for research careers in the field of molecular imaging of cancer. Molecular imaging explores and creates new approaches to visualize and quantify specific molecular and biochemical processes in intact living organisms and provides especially powerful tools for the study of cancer. SMIS trainees develop innovative molecular imaging approaches for the diagnosis and management of cancer, including the development of novel probes, instruments, and assays to characterize as well as guide the selection and/or discovery of novel treatments, and the evaluation of therapy response.

PI_NAMEs: LEVIN, CRAIG S (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: molecular imaging;Scholars Program

PROJECT_TITLE: Stanford Molecular Imaging Scholars (SMIS) Program


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_DEPT: DENTISTRY

PHR: Project Narrative Not Applicable

PI_NAMEs: PHILLIPS, SHANE A (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Behavior Therapy;Biomedical Research;career;career development;Chicago;Clinical;clinical center;clinical development;Clinical Research;Clinical Sciences;college;community engagement;Competence;Education;experience;Extramural Activities;Faculty;Funding;Goals;Growth;Health;Health Sciences;improved;innovation;Institution;Intervention;Mentors;Mentorship;Patient Care;Program Development;programs;Research;research faculty;Resource Development;Scholars Program;service utilization;Services;success;Therapeutic;Training;training opportunity;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Woman

PROJECT_TITLE: Institutional Career Development


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Nutrition;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative Glioma stem cells (GSCs) are a population of cells in glioblastoma that have stronger ability to self-renew in suboptimal environment than neural stem cells (NSCs), and killing GSCs provides a novel therapeutic opportunity. Dysregulated unsaturated fatty acid (UFA) biosynthesis in GSCs leads to defective endolysosome function, which consequently enhances their stemness and reduce ferroptosis, ultimately leading to gliomagenesis. Here we propose to explore the mechanisms by which endolysosome is regulated through UFA biosynthesis modulation in GSCs and to develop new therapeutic approaches to restore sensitivity to ferroptosis.

PI_NAMEs: HU, JIAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Agonist;Alternative Splicing;Brain Neoplasms;Cell membrane;cell type;Cells;Communication;Complement;Data;Daughter;desensitization;Down-Regulation;Endocytosis;Environment;Enzymes;fatty acid biosynthesis;Fatty Acids;flexibility;fluidity;Gene Expression;Genes;Glioblastoma;Glioma;Gliomagenesis;Goals;Heterogeneous-Nuclear Ribonucleoprotein L;Human;Immune;Impairment;In Vitro;in vivo;Invaded;lipid metabolism;Lipids;Mediating;Membrane;migration;Molecular;mRNA Precursor;mRNA Stability;Mus;Mutate;Mutation;neoplastic cell;nerve stem cell;neurodevelopment;Neurophysiology - biologic function;novel therapeutic intervention;novel therapeutics;Organelles;Outcome;Pathway interactions;Patients;pi bond;Polyunsaturated Fatty Acids;Population;PPAR-beta;prevent;Process;Prognosis;Proteins;receptor;receptor binding;Resistance;response;restoration;RNA;RNA Stability;RNA-Binding Proteins;Role;self-renewal;Signal Transduction;Stearoyl-CoA Desaturase;stem cell self renewal;stem cells;stemness;System;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapy development;trafficking;Tumor Suppression;Unsaturated Fatty Acids;Vesicle;Work

PROJECT_TITLE: The role of membrane homoeostasis of neural stem cell and glioma stem cells in neural development and gliomagenesis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Schizophrenia is a serious and debilitating psychiatric disorder, and it is a major public health concern for the Veterans Health Administration. Large gaps in our knowledge leave important questions unanswered, such as why the functional disability of schizophrenia is so severe, and why levels of functional impairment for patients have changed little over the past century, despite the availability of antipsychotic medications. Individuals with schizophrenia have marked impairments in processing social information (called social cognition), which result in misinterpretations of the intent of others, social withdrawal, and impaired daily social functioning. A challenge with developing new treatments for schizophrenia is that we do not understand the neural basis of social cognitive impairments. This study aims to address this issue by providing insights about the neural regions and the connections among them that underlie these social deficits.

PI_NAMEs: GREEN, MICHAEL F. (contact)

PROJECT_TERMS: Address;Affect;analytical method;Anatomy;Anterior;Antipsychotic Agents;Area;Brain;brain based;Brain region;cingulate cortex;Clinical assessments;Cognition;cost;Diffusion Magnetic Resonance Imaging;Dorsal;Emotional;emotional experience;Emotions;Empathy;Employment;Evaluation;functional disability;Functional impairment;Functional Magnetic Resonance Imaging;Goals;Grant;graph theory;Image;Impaired cognition;Impairment;indexing;Individual;insight;Insula of Reil;interest;Intervention;Knowledge;Lead;Matched Group;Measures;Medial;Mental disorders;mentalization;Modeling;Monitor;Moods;neural;Pain;Painless;Participant;Pathway Analysis;Patients;Pattern;Perception;Performance;Persons;Pharmaceutical Preparations;Population;Prefrontal Cortex;Process;Psychotic Disorders;Public Health;Published Comment;Publishing;Recovery;Regulation;Retrieval;Schizophrenia;segregation;social;social cognition;social deficits;Social disability;Social Functioning;social group;social neuroscience;Stimulus;System;Veterans;Veterans Health Administration;Withdrawal;Work

PROJECT_TITLE: Social Processing Systems in Veterans with Schizophrenia: Identifying Deficits in Brain Activation and Network Organization

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Schizophrenia

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Genetic, biochemical, and model organism studies indicate that genetic variants in the gene encoding the signaling protein TRIO contribute to the pathology of schizophrenia, autism spectrum disorders (ASD), and intellectual disability (ID). Our analysis of a cluster of variants associated with ASD and ID has identified a mechanism that controls TRIO's ability to signal. Our proposal aims to identify how disruption in this key signaling function impairs brain development.

PI_NAMEs: KOLESKE, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Adhesions;Alleles;Anxiety;autism spectrum disorder;Axon;Behavioral;Binding;Biochemical;Biochemical Process;Biophysics;Biosensor;Brain;brain behavior;brain size;Cells;Characteristics;comparative;Cytoplasmic Receptors;Cytoplasmic Tail;Defect;Dendrites;Development;Developmental Delay Disorders;Disease;Electron Microscopy;Electrophysiology (science);enzyme activity;Event;excitatory neuron;Family;Fluorescence Resonance Energy Transfer;Genes;Genetic;genetic risk factor;genetic variant;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Histopathology;impaired brain development;Impairment;Individual;individuals with autism spectrum disorder;Intellectual functioning disability;Interruption;Lead;light microscopy;loss of function;Measurement;Measures;Mediating;model organism;Modeling;Molecular;Morphology;motor impairment;Mus;Neurodevelopmental Disorder;neuron development;neuronal excitability;Neurons;neurotransmission;novel therapeutic intervention;optogenetics;Pathologic;Pathology;phosphoproteomics;Phosphorylation Site;Phosphotransferases;Process;Prosencephalon;Proteins;Proteomics;receptor;Receptor Activation;Recombinant Proteins;Regulation;rho;Risk;Sampling;Schizophrenia;schizophrenia risk;Signal Transduction;Signaling Protein;Social Interaction;Spectrin;success;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;tool;Translating;TRIO gene;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Dysregulation of TRIO GEF1 activity in neurodevelopmental disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Prevention;Urologic Diseases

PHR: Project Narrative: In patients with urinary stone disease, several knowledge gaps persist regarding the impact of fluid therapy in preventing stone recurrence, and the optimal care after insertion of a ureteral stent (a thin tube inserted into the ureter to prevent obstruction of the urine flow from the kidney). This application will address these gaps by assessing the effectiveness and safety of new behavioral strategies to increase urine fluid intake, and evaluating factors contributing to discomfort following stent insertion, with the ultimate goal of improving patient care.

PI_NAMEs: MAALOUF, NAIM M (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;arm;associated symptom;Behavior Therapy;Behavioral;Biological;Blood;Caring;Child;Childhood;Clinic;Clinical;clinical care;clinical center;Clinical Research;cohort;Collection;Communities;cost;COVID-19;COVID-19 pandemic;Data;Data Collection;Deposition;design;Disease;Effectiveness;effectiveness evaluation;electronic consent;Endocrinologist;Enrollment;Ensure;evaluation/testing;Event;Excision;experience;financial incentive;Fluid Therapy;follow-up;Foundations;Funding;Future;Goals;Health;health care service utilization;Hydration status;improved;Individual;innovation;insight;Institution;Intake;Intervention;Interview;Investigation;Kidney;Kidney Calculi;Knowledge;Lifting;Liquid substance;Lived experience;Manuscripts;Measures;Medical;Medicine;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrolithiasis;novel;observational cohort study;Obstruction;Operative Surgical Procedures;Output;Pain;Participant;participant enrollment;Patient Care;Patient Recruitments;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perioperative complication;Philadelphia;Plasma;Prevalence;prevent;Prevention;primary endpoint;Problem Solving;Procedures;programs;prospective;Prospective, cohort study;Psychosocial Assessment and Care;Public Health;Publications;Questionnaires;radiologist;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Recurrent disease;Regimen;Reporting;repository;Research;Research Design;Research Institute;Research Personnel;Resources;response;Safety;Sampling;Science;Scientist;Sensory;Serum;Site;Societies;Stents;Structure;success;Symptoms;Texas;therapy design;Thinness;Time;Touch sensation;treatment arm;Tube;Universities;Ureter;Ureteroscopy;urinary;Urinary Calculi;Urine;urologic;Urologist;virtual visit;Visit;Washington;Water;Whole Blood

PROJECT_TITLE: Fluid Therapy and Stent Management in Nephrolithiasis, USDRN extension


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Prevention;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE There is an acute need for more, and better prepared, STEM-H (science, technology, engineering, mathematics, and health) professionals, especially trained in cancer and health focused careers. We address this national priority through the proposed cancer research education program for undergraduate students that provides: inquiry-based research seminars, innovative mentored cancer research experiences, team-building activities, and career development mentoring. We believe this will facilitate and support undergraduate students in their completion of a degree in a STEM-H field and to pursue graduate or professional schools, while encouraging their interests in research careers.

PI_NAMEs: ADSUL, PRAJAKTA ;GILLETTE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acute;Address;anti-cancer research;Behavior Therapy;Behavioral;Behavioral Research;Biomedical Research;cancer care;Cancer Control;cancer health disparity;cancer prevention;cancer risk;care delivery;career;Career Choice;career development;Clinical;cohort;Collaborations;Communication;Communities;Comprehensive Cancer Center;design;Development Plans;Discipline;Disease;disease diagnosis;education pathway;education research;Educational Curriculum;Elevator;Engineering;Epidemiology;experience;Faculty;Fostering;Genetic Screening;genome sciences;Geographic Locations;Goals;Graduate Education;graduate school;graduate student;Health;health equity;health equity promotion;Health Professional;Health Sciences;improved;Incidence;Individual;innovation;interest;Intervention;Investigation;Knowledge;leadership development;literacy;Malignant Neoplasms;Mathematics;Mentors;Methods;Minority Status;Mission;Morbidity - disease rate;mortality;New Mexico;next generation;Outcome;peer;peer coaching;population health;Population Sciences;Postdoctoral Fellow;precision medicine;Preparation;Problem Solving;Professional Education;programs;recruit;Research;research and development;Research Personnel;Resources;Risk;risk prediction;Risk Reduction;rurality;Scholarship;Schools;Science;screening;Screening for cancer;Self Efficacy;skills;Societies;socioeconomics;Students;survivorship;Technology;Training;Training Programs;Translations;undergraduate research;undergraduate student;Universities;Writing

PROJECT_TITLE: Cancer Research - Scholarship and Training Experience's in Population Sciences" (C-STEPS)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The provision of health care is undergoing a genomics revolution. With massively parallel sequencing as a disruptive technology, our understanding of the genetics and genomics underlying human disease is taking an exponential leap forward. However, few physicians and scientists have been trained to understand these data, let alone take advantage of them to translate into improvements in patient care. We propose to continue our post-doctoral training program for the next generation of physician and scientist leaders in Genomic Medicine in the Perelman School of Medicine, Penn Medicine, and the Children’s Hospital of Philadelphia. The program draws upon the extraordinary strengths at these institutions in the areas of genomics, translational medicine, and bioinformatics, and prepares the trainees to embark upon careers applying Genomic Medicine to the improvement of health care through advances in diagnosis, therapeutics and prevention.

PI_NAMEs: NATHANSON, KATHERINE L. (contact);RITCHIE, MARYLYN D

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Genomic medicine;post-doctoral training;Training Programs

PROJECT_TITLE: Postdoctoral Training Program in Genomic Medicine


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE This program is designed to study how inflammation contributes to development of cancer properties responsible for disease progression and resistance to different therapies. This will be accomplished by study of specific mechanisms activated in the various cell types that compose the tumor. Accomplishment of these aims will provide multiple opportunities for novel therapeutic intervention by targeting these key activities and properties that are major impediments to successful treatment.

PI_NAMEs: STARK, GEORGE ROBERT (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Ablation;Affect;Animal Model;Biological;Cancer Biology;cancer cell;cancer cell differentiation;cancer stem cell;cancer therapy;Cell Communication;Cell Mobility;cell type;Cells;cellular targeting;Chemoresistance;chemotherapy;Chronic;Complex;cytokine;Cytokine Network Pathway;Cytokine Signaling;Data;design;Development;Disease Progression;Disease Resistance;Dissection;Epithelium;Equilibrium;Evaluation;Event;Failure;Fibroblasts;Fibrosis;Fostering;Gene Expression;Genetic Transcription;Goals;IL17 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immunotherapy;improved;in vivo;Inflammation;Inflammatory;insight;Interferon Type I;Interferon-beta;Interferons;Knowledge;Lead;Link;MADH3 gene;Malignant Neoplasms;Mediating;Mesenchymal;Modality;Molecular;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;Phenotype;Phosphorylation;Physical shape;Population;posttranscriptional;pre-clinical assessment;Process;Production;programs;Property;Publishing;Recurrent disease;Repression;Resistance;Resistance development;response;RNA Binding;Role;self-renewal;Shapes;Signal Pathway;Signal Transduction;Standardization;STAT2 gene;STAT3 gene;stem;Stem Cell Development;stemness;Stimulator of Interferon Genes;Stromal Cells;Testing;Therapeutic;therapy design;therapy resistant;Transforming Growth Factor beta;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenesis;Work

PROJECT_TITLE: Molecular Dissection of Cytokine Crosstalk in the Tumor Microenvironment


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Lung;Lung Cancer;Women's Health Research

PHR: Project Narrative Progression and therapeutic failure are two major hurdles for cancer patients. We have identified novel regulatory pathways that control cancer progression and responses to both chemotherapy and immunotherapy. In this proposal, we will elucidate underlying mechanisms and develop novel strategies to overcome resistance to therapy.

PROJECT_TERMS: A549;Adjuvant;Affect;Agonist;Alanine;Animal Model;anti-PD-1;Antitumor Response;Binding;Biological;Biopsy;Breast Cancer Cell;cancer cell;Cancer Control;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;Cell Death Induction;Cells;Chemicals;Chemoresistance;chemotherapeutic agent;chemotherapy;Cisplatin;Colon Carcinoma;colon tumorigenesis;Complex;cytokine;Cytostatics;Cytotoxic T-Lymphocytes;Data;Development;Dissection;DNA;Epithelium;Evaluation;Failure;Gene Expression;Genes;Genetic Transcription;Growth;Human;IL17 gene;Immune;immune cell infiltrate;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Inflammatory;Inhibition of Cancer Cell Growth;Interferon Type I;Interferon-beta;interferon-stimulated gene factor 3;Interleukin-6;ISGF3G protein;Knock-in Mouse;Knowledge;Lung Adenocarcinoma;lung cancer cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mesenchymal;mimetics;Molecular;Mus;Mutation;Myelogenous;Myeloid Cells;novel;novel strategies;Outcome;Phenotype;Phosphorylation;Phosphotransferases;Play;prevent;Prevention;Production;Prognosis;programs;Property;Protein Tyrosine Kinase;Regulatory Pathway;Resistance;response;Role;sensor;Shapes;Skin Cancer;Skin tumorigenesis;Specimen;Standardization;STAT1 gene;STAT2 gene;STAT3 gene;stem;stem cell biomarkers;stem cells;stemness;STING agonists;TBK1 gene;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Threonine;transcription factor;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Tyrosine Phosphorylation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel roles of STAT2 and IFN-I in tumorigenesis and responses to therapy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

PHR: PROJECT NARRATIVE Two important factors that regulate Triple Negative Breast Cancer (TNBC) metastasis and recurrence are: (i) the differentiation status of the cancer cells, and (ii) the functionality of anti-tumor immunity, both of which are highly influenced by the cytokines, Transforming Growth Factor-beta (TGFB) and Interferon-beta (IFNB). We find that the actions of TGFB and IFNB oppose one another in regulating both cancer cell differentiation and immune system function within the tumor microenvironment. We propose here to define how TGFB and IFNB antagonize one another and test novel therapeutic approaches to shift the balance towards active IFNB and away from TGFB signaling, with the goal of improving outcomes for patients with metastatic TNBC

PI_NAMEs: JACKSON, MARK W. (contact)

PROJECT_TERMS: Adjuvant Chemotherapy;aggressive breast cancer;Animal Model;autocrine;Binding;Binding Sites;breast cancer metastasis;Breast Cancer Model;breast cancer progression;cancer cell;cancer cell differentiation;cancer invasiveness;cancer recurrence;cancer therapy;cell behavior;Cells;chemotherapy;Chromatin;Clinical;Combined Modality Therapy;cytokine;Dissection;epigenomics;Epithelium;Equilibrium;Family;Gene Expression;Genes;Genetic Transcription;Goals;IL17 gene;Immune;Immune checkpoint inhibitor;Immune system;immune system function;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;in vivo evaluation;Interferon Activation;Interferon-beta;Interferons;Interleukin-6;MADH3 gene;Malignant Neoplasms;Mediating;Mesenchymal;Messenger RNA;mimicry;Molecular;Neoadjuvant Therapy;novel;novel therapeutic intervention;novel therapeutics;paracrine;Patient-Focused Outcomes;Patients;Phosphorylation;prevent;Production;programs;receptor;Recurrence;refractory cancer;Regulation;Repression;Resistance development;response;restoration;RNA Binding;sensor;Signal Transduction;Specimen;standard of care;Standardization;STAT1 gene;STAT2 gene;STAT3 gene;stem;Stromal Cells;synergism;Testing;therapy resistant;Threonine;Time;Transforming Growth Factor beta;Translations;Treatment Failure;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor initiation;tumor microenvironment;Viral

PROJECT_TITLE: Shifting the balance between IFN-I and TGF-beta to improve cancer therapy