NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative Abnormal vision during a childhood ‘critical period’ can cause amblyopia, also known as lazy eye, a disorder comprising several deficits in spatial vision including poor acuity and/or impaired depth perception. The proposed research is relevant to public health because knowledge of the signaling pathways that limit flexibility with neural circuitry sufficient to restore acuity and eye dominance will improve our understanding of targets for therapeutic intervention. The proposed research is relevant to the mission of the NEI/NIH to increase understanding of the critical period in order to determine how experience-dependent plasticity alters connectivity in the developing visual system.

PI_NAMEs: MCGEE, AARON W (contact);QIU, SHENFENG

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;Affect;aggrecan;Alleles;Amblyopia;Animal Model;area striata;autism spectrum disorder;Behavioral Assay;Brain;brain circuitry;Calcium;Childhood;Chondroitin ABC Lyase;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfate Proteoglycan;clinically relevant;conditional mutant;critical developmental period;critical period;dark rearing;Depth Perception;Development;Disease;Disinhibition;Dissection;effective therapy;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Enzymes;Equilibrium;excitatory neuron;experience;experimental study;Extracellular Structure;Eye;flexibility;Functional disorder;Gene Expression;Genes;Genetic;genetic manipulation;Image;Impairment;improved;In Vitro;in vivo;in vivo calcium imaging;Injections;Injury;Interneurons;Knowledge;Lazy Eyes;Measures;Mission;Modeling;monocular deprivation;Mus;Nerve Degeneration;neural circuit;neuronal excitability;Neuronal Plasticity;Neurons;neurotransmission;Ocular Dominance;Parvalbumins;Population;progenitor;Property;Public Health;Rattus;Recovery;Research;response;Role;selective expression;Signal Pathway;Slice;Source;spatial vision;Stains;Study models;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;United States National Institutes of Health;Vision;Vision Disorders;Visual;Visual Acuity;Visual Cortex;Visual impairment;visual plasticity;Visual System

PROJECT_TITLE: Dissecting the role of aggrecan and perineuronal nets in visual plasticity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Rehabilitation;Stroke

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: NARRATIVE Neuroimaging methods are invaluable for managing the treatment of stroke patients in the acute phase of guiding reperfusion and salvaging tissue, and are being used more and more to understand the effect of and ultimately guide treatments in the chronic phase of functional brain recovery. However, there is a great need for studies in well-established and properly controlled preclinical stroke models to evaluate the evolution of the structural and functional aspects of chronic neurovascular recovery, for a better mechanistic understanding of these biological interactions, and to understand their prognostic value for predicting behavioral outcomes following stroke. Our aims are designed to meet these needs by using a novel combination of optical technologies and a preclinical stroke model, and will provide a solid foundation for the continued and growing use of fMRI and fNIRS for studying human brain functional recovery post-stroke.

PI_NAMEs: BOAS, DAVID A (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Basement membrane;behavior prediction;Behavioral;behavioral outcome;Binding;Biological;Blood capillaries;Blood Cells;Blood flow;Blood Vessels;Brain;Brain region;Calcium;Cell Adhesion Molecules;Cells;Chronic;Chronic Phase;Clinical;constriction;Contralateral;Correlation Studies;Coupling;Data;design;Elements;Endothelial Cells;Endothelium;Ensure;Event;Evolution;excitatory neuron;Exposure to;Foundations;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;functional outcomes;Goals;hemodynamics;Heterogeneity;Human;Image;improved;Incidence;Individual;Infarction;Investigation;Ischemic Stroke;Leukocytes;Link;Measures;Mechanics;Metabolic;Methodology;Methods;Modeling;Monitor;neural;neuroimaging;Neurons;neurophysiology;neurovascular;neurovascular coupling;neurovascular unit;neutrophil;new technology;novel;Optical Coherence Tomography;Optics;Organization administrative structures;Outcome;Oxygen;Patients;Pericytes;Phase;Population;post stroke;pre-clinical;prognostic value;Recovery;Recovery of Function;Reperfusion Therapy;response;restoration;Role;serial imaging;Signal Transduction;Site;Solid;Speed;Stimulus;Stroke;stroke model;stroke outcome;stroke patient;stroke recovery;stroke survivor;stroke therapy;Surface;Technology;Testing;Tissues;tool;two photon microscopy;Variant

PROJECT_TITLE: Neurophotonic Advances for Mechanistic Investigation of the Role of Capillary Dysfunction in Stroke Recovery


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Nutrition;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_NAME: MODULATION THERAPEUTICS, INC.

ORG_STATE: WV

PHR: PROJECT NARRATIVE A novel fatty acid synthesis inhibitor, MTI-301 (aka SSI-4), sensitizes cancers to immune  checkpoint inhibitors. This new therapeutic strategy should increase the number of patients  responding to treatment and may lead to cures through prolonged activation of immune T cells in  drug resistant cancers.

PI_NAMEs: COPLAND, JOHN A.;HAYES, KAREN E (contact);TAN, WINSTON

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Acids;adaptive immune response;adaptive immunity;Adjuvant Therapy;Affect;Anabolism;Analytical Chemistry;antagonist;anti-cancer;anti-PD1 antibodies;anti-PD1 therapy;antitumor effect;Apoptotic;arm;attenuation;Biological Availability;Biological Markers;Bladder;Breast;calreticulin;cancer cell;Cancer cell line;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;cancer survival;cancer type;Canis familiaris;capsule;carcinogenesis;Cell Death;cell killing;Cell Line;Cell Physiology;Cell Survival;Chemoresistance;clinical practice;Clinical Trials;Clinical Trials Design;Colon;combat;Combined Modality Therapy;computational chemistry;Data;deprivation;design;Disease;Dose;Drug Formulations;Drug Kinetics;Drug resistance;early phase clinical trial;endoplasmic reticulum stress;Enzymes;ERBB2 gene;Essential Fatty Acids;fatty acid biosynthesis;fatty acid metabolism;Fatty Acids;first-in-human;Food and Drug Administration Drug Approval;Formulation;Generations;Grant;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immunocompetent;immunogenic;immunogenicity;Immunology;Immunosuppression;Immunotherapy;in vivo;Inflammatory;Inhibition of Cell Proliferation;inhibitor;insight;Investigation;Kidney;Lead;Life;Link;lipid biosynthesis;lipid metabolism;Liver;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mediating;Mediator;Melanoma Cell;Membrane;Metabolic;Monounsaturated Fatty Acids;mouse model;Mus;neoplastic cell;New Drug Approvals;No-Observed-Adverse-Effect Level;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient;Nutrient availability;Oncogenic;Oral;Ovarian;overexpression;Pathway interactions;patient response;patient stratification;Patients;PD-1 inhibitors;Pharmacology and Toxicology;Phase;Phase I Clinical Trials;phase I trial;Phase III Clinical Trials;Phenotype;Play;predictive marker;Principal Investigator;Property;Proteins;refractory cancer;Reporting;response;response biomarker;Role;Saturated Fatty Acids;Signaling Molecule;Site;Small Business Innovation Research Grant;Small Interfering RNA;small molecule;Solid Neoplasm;Stearoyl-CoA Desaturase;synergism;Synthesis Chemistry;T-Cell Activation;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Thyroid Gland;Toxic effect;Toxicology;Translations;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumorigenic;WNT Signaling Pathway

PROJECT_TITLE: Modulation of cancer induced immune suppression via inhibition of SCD1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(12)B]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Developing accurate, cost-effective, and scalable biomarkers of aging and age-related frailty could help in assessing longevity interventions in the lab or patient outcomes in the context of clinical trials of age-related disease. This proposal describes the development of a method for high-throughput assay of DNA methylation clocks, a robust class of age predictors, which will be used to make a novel type of biomarker based on age and mouse frailty scores. Additionally, this research will probe the mechanistic underpinnings of DNA methylation clocks and epigenomic change with age in mouse muscle using the novel method for clock analysis in combination with established genomic techniques.

PI_NAMEs: GRIFFIN, PATRICK  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Age;age related;age related changes;age-related disease;Aging;aging biomarker;aging related;Automobile Driving;Binding;biological age;Biological Aging;Biological Assay;Biological Markers;Biology;Blood specimen;Caloric Restriction;Categories;Chronology;Clinical;Clinical Trials;cohort;cost;cost effective;Cytosine;Development;Developmental Gene;DNA;DNA Methylation;DNA methylation profiling;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenomics;experimental study;frailty;Functional disorder;gene network;Gene Silencing;Genes;genetic association;genomic locus;genomic profiling;Genomics;Heritability;Heterochromatin;Heterogeneity;high throughput screening;High-Throughput Nucleotide Sequencing;histone modification;In Vitro;indexing;insight;Intervention;Longevity;Mammals;Measurement;Measures;Methods;Methylation;Modeling;Molecular;Molecular Target;mortality;multiple omics;Mus;Muscle;muscle aging;Muscle Fibers;Muscle satellite cell;Mutation;novel;novel marker;Patient-Focused Outcomes;Persons;Pharmacologic Substance;Phase;physical conditioning;Postdoctoral Fellow;Process;Reporter;Research;Research Project Grants;RNA;Sampling;screening;Sirolimus;stem;stem cells;Techniques;Technology;Testing;Ticks;Tissue Sample;tool;Training;transcription factor;virtual;Work

PROJECT_TITLE:
A novel method to identify regulators of biological aging
based on high-throughput sequencing of epigenetic clocks.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Data Science;Infectious Diseases

ORG_CITY: GENEVA

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: SWISS INSTITUTE OF BIOINFORMATICS

PHR: Project Narrative The Pathogen Data Network offers a unique opportunity to support the mobilization, sharing and interpretation of pathogen- and infectious-disease data, laying the foundation for establishing data-sharing policies that tackle well-known barriers such as trust, ownership and data FAIR- ification. This ambitious project will establish a global network of engaged user communities and provide technical specifications and reference implementations for facilitating the sharing of data fairly, equitably and responsibly for the benefit of research and, above all, public health. Thanks to this international undertaking supported by NIH, countries will be better equipped to work collaboratively to deal with potential future outbreaks and advance their research on infectious diseases.

PI_NAMEs: AARESTRUP, FRANK MØLLER;BROOKSBANK, CATHERINE ELIZABETH LOUISE;BURDETT, ANTHONY JOHN CHARLES;CHRISTOFFELS, ALAN ;COCHRANE, GUY RALPH;CSABAI, ISTVAN ;CUESTA, ISABEL ;DE GRAAF, MIRANDA ;HALABI, SAM FO;HERMJAKOB, HENNING ;HJERDE, ERIK ;KOOPMANS, MARION PETRONELLA GERARDA;MONZON, SARA ;NEVES, AITANA  (contact);OUDE MUNNINK, BAS B;PALAGI, PATRICIA ;RUNG, JOHAN ;SCHOLZ, AMBER HARTMAN;TIFFIN, NICKI ;WILLIAMS, JASON

PROGRAM_OFFICER_NAME: RUTVISUTTINUNT, WIRIYA

PROJECT_TERMS: Address;Adoption;Agreement;Benchmarking;beneficiary;benefit sharing;Clinical;clinical epidemiology;Cloud Computing;cohort;Communicable Diseases;Communities;Community of Practice;Computer software;computerized data processing;Computing Methodologies;Country;COVID-19;dashboard;Data;data access;data hub;data ingestion;data integration;Data Linkages;data management;data platform;data resource;Data Set;data sharing;data tools;Decision Making;Dedications;Development;Disease;Disease Outbreaks;Education and Outreach;Elements;empowerment;Ensure;epidemiologic data;Equity;Ethical Issues;Ethics;evidence base;FAIR principles;Food Chain;foodborne;Fostering;Foundations;future outbreak;Human;Image;implementation facilitation;Infrastructure;innovation;International;Knowledge;knowledgebase;Legal;Link;low and middle-income countries;member;Methods;Molecular;open data;Outcome;outreach program;Ownership;Pan American Health Organization;pandemic preparedness;pathogen;pathogen genomics;Pathogenicity;Pathway interactions;patient privacy;Policies;Proteins;Protocols documentation;Public Health;Public Health Applications Research;Readiness;Regulation;repository;Research;Research Support;Resources;response;Running;Severities;Sewage;Specific qualifier value;surveillance network;System;Systems Analysis;Training Programs;transcriptomics;Trust;trustworthiness;United States National Institutes of Health;vector;Virus;Work;World Health Organization

PROJECT_TITLE: Pathogen Data Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RK-M (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Regenerative Medicine

ORG_CITY: Ellsworth

ORG_NAME: REVIDIA THERAPEUTICS, INC

ORG_STATE: ME

PHR: PROJECT NARRATIVE  Most patients with Duchenne muscular dystrophy (DMD), a devastating inherited muscle wasting disease, die from heart failure in their second or third decade of life. We have identified a novel, subcutaneously administered drug candidate that slows the progressive damage to the heart associated with DMD. Our proposed studies will carry out safety and toxicology testing of this drug candidate, which is the final requirement before clinical trials in humans can begin.

PI_NAMEs: STRANGE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 10 year old;Acute;ADME Study;Adult;Age Years;aged;Animal Experimentation;Animal Model;Animal Muscular Dystrophy;Anti-Hypertensive Agents;Biological;Biological Assay;Birth;Blinded;Canis familiaris;Cardiac;Cardiac Myocytes;cardiac repair;Cardiomyopathies;Cardiovascular system;Caring;Cause of Death;cell injury;Cessation of life;chemical property;Child;Chronic;Clinical;Clinical Pathology;Clinical Trials;Data;Data Analyses;Development;Dilated Cardiomyopathy;Dose;drug candidate;Drug Kinetics;drug testing;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;efficacy testing;EFRAC;experimental analysis;Formulation;genotoxicity;good laboratory practice;Guidelines;Heart;Heart failure;heart function;Heart Injuries;Home;Human;improved;In Vitro;in vivo;Industry;Infarction;Inflammatory;Inherited;inhibitor;Injections;Injury;innovation;International;Label;Lead;Left ventricular structure;Legal;Life;Life Expectancy;life span;manufacture;Maximum Tolerated Dose;Measurement;Methods;Micronucleus Tests;Microscopic;Mission;Modeling;mortality;Mus;Muscle Cells;muscle degeneration;Muscle Fibers;muscle regeneration;Muscular Atrophy;Mutagenicity Tests;Mutation;Myocardial Infarction;Myocardium;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Phase 1/1b Clinical Trial;pre-Investigational New Drug meeting;pressure;Process;Protein Tyrosine Phosphatase;Protocols documentation;PTPN1 gene;Quality of life;Randomized;Rare Diseases;Rattus;regenerative;Regenerative Medicine;repaired;Reporting;respiratory;Respiratory System;Safety;safety testing;Self Administration;Skeletal Muscle;Small Business Innovation Research Grant;small molecule;Smooth Muscle Myocytes;Steroids;Structural Protein;subcutaneous;subcutaneous drug administration;Teenagers;Testing;Therapeutic;therapeutic development;therapy development;tissue regeneration;tissue repair;Tissues;Toxic effect;Toxicity Tests;Toxicokinetics;Toxicology;Wasting Syndrome;Workload

PROJECT_TITLE: IND-enabling safety and toxicity testing of a subcutaneous formulation of the PTP1B inhibitor MSI-1436, a novel strategy for treating fatal cardiomyopathy in Duchenne muscular dystrophy patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEWARK

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Intestinal epithelial cell DNA methylation patterns, which can be reversed by the ten-eleven translocation (TET) enzymes, can be altered by microbiota. How TET-mediated DNA oxidation dynamics affect mucosal innate immune response and inflammatory susceptibility are unknown. This MPI project uses mouse genetics and DNA epigenetic approaches to elucidate the contribution of TET-dependent DNA oxidations for the function of intestinal epithelial cells, Paneth cell and intestinal stem cells.

PI_NAMEs: ETCHEGARAY, JEAN-PIERRE  (contact);GAO, NAN

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Adult;Affect;alpha ketoglutarate;Base Excision Repairs;Binding;biological adaptation to stress;Biology;Carbon;cell type;Cells;chemically induced colitis;Chemicals;Chromatin;Citric Acid Cycle;cofactor;Colitis;Collaborations;commensal bacteria;commensal microbes;coping;Cues;Cytosine;Data;demethylation;Development;dextran sulfate sodium induced colitis;Dioxygenases;Disease;Disease susceptibility;DNA;DNA Methylation;DNA Modification Methylases;Embryonic Development;Ensure;enteric pathogen;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Epithelial Cells;Epithelial Physiology;epithelial repair;Epithelium;Excision;Family;Fumarates;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Genes;Genetic Transcription;genome-wide;genomic locus;Gnotobiotic;high risk;Homeostasis;Impairment;Infection;Inflammatory;Injury;Innate Immune Response;innovation;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Knowledge;Maintenance;Mammals;Maps;Mediating;Methyl-CpG-Binding Protein 2;methylation pattern;Microbe;microbial;microbiota;mouse genetics;mouse model;Mucous Membrane;Mus;Notch and Wnt Signaling Pathway;novel;oxidation;Paneth Cells;pathogen;Pathogenicity;Pathway interactions;Physiological;Polymerase;Positioning Attribute;Predisposition;programs;Regulation;response;RNA Polymerase II;Role;Salmonella typhimurium;Signal Transduction;Site;stem cells;Stress;stressor;Succinates;Thymine DNA Glycosylase;Time;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Up-Regulation;Work

PROJECT_TITLE: Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Eye Disease and Disorders of Vision;Heart Disease;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Dry age-related macular degeneration (AMD) is the leading cause of blindness in the United States. The available treatment options for dry AMD are limited. The core objective of the proposed study is to advance safe and effective new therapies for addressing this condition.

PI_NAMEs: CIOFFI, CHRISTOPHER L.;PETRUKHIN, KONSTANTIN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Affect;Age;age related;Age related macular degeneration;All-Trans-Retinol;Ames Assay;Amyloid;amyloid fibril formation;amyloid formation;Amyloidosis;antagonist;Atrophic;Binding;Binding Sites;Biological Assay;Biological Availability;Blindness;Blood Circulation;Cardiac;Cardiac Death;Cardiomyopathies;Cardiovascular system;Case Study;Chromosome abnormality;Circulation;Clinical Trials;comorbidity;Complex;Congestive Heart Failure;cytotoxic;Deposition;Developed Countries;Development;Disease;Dissociation;Dose;drug candidate;Dryness;effective therapy;Elderly;Elements;enantiomer;epidemiology study;Evaluation;experimental study;extracellular;Eye;Fenretinide;Formulation;Frequencies;Funding Mechanisms;General Population;Generations;glomerular filtration;Goals;Heart;Human;In Vitro;in vivo;Individual;Kinetics;Lesion;Ligands;Lipofuscin;Lung;Macular degeneration;Mediating;Methods;Micronucleus Tests;Modeling;Mus;Myocardial dysfunction;non-genetic;Nonexudative age-related macular degeneration;nonhuman primate;novel;novel therapeutics;Older Population;Oral;Organ;Pathogenesis;Pathologic Processes;Pathology;Patients;Peripheral Blood Lymphocyte;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Polymorph;Population;pre-Investigational New Drug meeting;Prealbumin;preclinical development;preclinical efficacy;Predisposition;prevent;Property;Rattus;RBP4 gene;Retina;Retinaldehyde;Retinoids;Route;Safety;scale up;Senility;Serum;Site;small molecule;Sodium Chloride;Specificity;Stargardt's disease;Structure of retinal pigment epithelium;Testing;Thyroxine;Tissues;Toxicology;United States;Virulence Factors;visual cycle

PROJECT_TITLE: Advancing the small molecule drug candidate with dual specificity as a therapy for dry AMD

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (06)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: The Bacterial and Viral Bioinformatics Center (BV-BRC), a unified knowledgebase and analysis resource, serves over 45,000 infectious disease researchers studying bacterial and viral pathogens by providing integrated access to omics data, analysis services, workspace, and extensive training material. We propose to maintain, extend, and enhance BV-BRC by building innovative tools for comprehensive bacterial, viral and metagenomic analyses, aiding development of diagnostics and therapeutics, developing a next-generation AI- driven natural language-based user interface, and honing tools and procedures for pandemic preparedness. We are strongly committed to enhancing accessibility to bioinformatics resources through our robust training and outreach program, with special emphasis on increasing outreach to students by conducting training for educators.

PI_NAMEs: STEVENS, RICK L. (contact)

PROJECT_TERMS: Acceleration;Archaea;Artificial Intelligence;Bacteria;Bacterial Transformation;Bacteriophages;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological;Biology;career;Cell Nucleus;Chicago;collaborative environment;combat;Communicable Diseases;Communities;comparative;Contracts;COVID-19;Data;Diagnostic;diagnostic development;Disease;Disease Outbreaks;Documentation;drug development;drug discovery;drug resource;Education and Outreach;Elements;Ensure;Equity;equity, diversity, and inclusion;experience;Fostering;Funding;Funding Opportunities;Future;future outbreak;future pandemic;Genes;Genomics;Goals;Growth;Human;human pathogen;Illinois;improved;Infectious disease threat;Infectious Diseases Research;Informatics;innovation;Institution;Intention;Knowledge;knowledgebase;member;Metadata;Metagenomics;microbiome;minority communities;minority investigator;Minority-Serving Institution;Mission;Monkeypox;Morbidity - disease rate;mortality;Multiomic Data;National Institute of Allergy and Infectious Disease;natural language;next generation;novel;Organism;outbreak preparedness;outreach;outreach program;pandemic disease;pandemic preparedness;Pathogenesis;pathogenic bacteria;pathogenic microbe;pathogenic virus;Pathogenicity;Phenotype;Positioning Attribute;Privatization;Procedures;Process;programs;Public Health;public health emergency;Publishing;Readiness;Recording of previous events;Research;Research Personnel;Resources;response;Running;Services;Students;Teacher Professional Development;Technology;Testing;Therapeutic;tool;Training;Translating;underserved community;United States National Institutes of Health;Universities;usability;Viral;virome;Virus;Visualization software

PROJECT_TITLE: The Bacterial and Viral Bioinformatics Resource Center (BV-BRC)


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_CITY: WORCESTER

ORG_NAME: MICROBIOTIX, INC

PHR: PROJECT NARRATIVE The opportunistic Gram-negative pathogen Pseudomonas aeruginosa (Paer) is a leading cause of serious burn wound infections that are difficult to treat and frequently lead to sepsis, resulting in a high mortality rate, even when patients are treated with appropriate antibiotics. To address the need for treatments that prevent sepsis, we will evaluate the ability of a novel class of potential drugs that inhibit the type 3 secretion system (T3SS), the major mechanism that Paer uses to establish infections and to spread throughout the host, as a novel treatment for serious burn wound infections. Successful completion of this project will result in 1-2 validated T3SS inhibitors that will be developed further as a novel drug that will be administered with an FDA-approved antibiotic to treat Paer burn wound infections and prevent sepsis.

PI_NAMEs: OPPERMAN, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: adaptive immune response;Address;Adopted;Antibiotic Resistance;Antibiotics;Bacteria;Biological Assay;Blood;burn therapy;burn wound;Cells;Cessation of life;Chemicals;Colistin;cost;cytokine;Data;Death Rate;Development;dimer;Dose;drug discovery;Drug Kinetics;Enzymes;Epithelium;Evaluation;Exhibits;Exotoxins;experimental study;FDA approved;fighting;General Hospitals;Goals;Growth;heat injury;Hospitalization;Human;Immune;Immunocompetent;Immunosuppression;In Vitro;in vitro activity;in vitro Model;in vivo;in vivo evaluation;Infection;Inflammatory;inhibitor;Innate Immune System;Innovative Therapy;Intestinal permeability;Intoxication;Ion Channel;Laboratories;Lead;Liver;Lung;Massachusetts;Medical;medical schools;Meropenem;Microbial Biofilms;Modality;Modeling;Molecular;monomer;Multiple Bacterial Drug Resistance;Mus;mutant;neutrophil;novel;novel therapeutics;Nutrient;Organ;Organoids;pathogen;Patients;Penetration;Pharmaceutical Preparations;Phase;Plasma;Play;pneumonia model;Prevalence;prevent;Production;programs;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Reaction;receptor;Research;Resistance;resistant strain;Role;Sepsis;Series;severe burns;Site;small molecule;small molecule inhibitor;Spleen;Syringes;Therapeutic;Therapeutic Agents;Thick;Time;Tissues;Type III Secretion System Pathway;Virulence;Virulence Factors;Wound Infection;Wound models

PROJECT_TITLE: Proof of concept experiments for T3SS inhibitors against burn wound infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: In this proposal, we will overcome bottlenecks in cancer drug discovery by developing innovative next-generation approaches for targeted protein degradation (TPD) using covalent chemoproteomic strategies, including expanding upon rational chemical design strategies to discover molecular glue degraders and uncover permissive E3 ligases for TPD applications and covalently targeting and destabilizing undruggable oncogenic transcription factors.

PI_NAMEs: NOMURA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Antineoplastic Agents;Binding;cancer therapy;Chemicals;chemoproteomics;CTNNB1 gene;Cysteine;Data;design;Disease;DNA-Protein Interaction;drug discovery;Drug Targeting;druggable target;functional genomics;Genetic Transcription;Genomic approach;Glues;Human;innovation;interest;Ligands;link protein;Malignant Neoplasms;Mediating;Modality;Molecular;multicatalytic endopeptidase complex;next generation;Oncogenic;permissiveness;Pharmaceutical Chemistry;Phenotype;Protac;protein complex;protein degradation;protein protein interaction;Proteins;rational design;Recombinant Proteins;Research;small molecule;Structure;Substrate Interaction;targeted cancer therapy;Therapeutic;transcription factor;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;vector

PROJECT_TITLE: Harnessing E3 Ligases for Cancer Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-K (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Data Science;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE This proposal presents a detailed plan for the PsychENCODE Consortium’s Data Analysis and Coordination Center (DACC), which will play a crucial role in coordinating and enhancing the joint endeavors of the Consortium. The DACC will be dedicated to curating, submitting, and harmonizing diverse datasets produced by the Consortium. By emphasizing efficient data management and fostering collaboration, the DACC aims to support the Consortium's progress in accelerating our knowledge of brain function and neuropsychiatric disorders.

PI_NAMEs: GERSTEIN, MARK BENDER;WENG, ZHIPING  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Acceleration;Affect;autism spectrum disorder;Automobile Driving;Bipolar Disorder;Brain;BRAIN initiative;Brain region;cell type;Collaborations;collaborative environment;Communication;Communities;computerized data processing;Data;data access;Data Analyses;data archive;data curation;data integration;data management;data quality;Data Set;Data Storage and Retrieval;data submission;data tools;data visualization;data wrangling;Dedications;Development;Dimensions;Disease;disorder risk;diverse data;Encyclopedia of DNA Elements;Ensure;Fostering;Functional disorder;functional genomics;Funding;Genes;Genetic;genomic data;Genotype-Tissue Expression Project;Goals;Grant;Human;Human Genome;Individual;Information Management;innovation;insight;Joints;Knowledge;Manuscripts;Maps;meetings;member;Mental disorders;Mental Health;Metadata;Mission;Molecular;Molecular Profiling;Multiomic Data;National Institute of Mental Health;neuronal circuitry;neuropsychiatric disorder;Nucleic Acid Regulatory Sequences;Play;Process;programs;Quality Control;Regulatory Element;Research;Research Personnel;Resources;Role;Schizophrenia;Scientific Advances and Accomplishments;Shapes;Therapeutic;trend;Untranslated RNA;working group

PROJECT_TITLE: PsychENCODE Data Analysis and Coordination Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (02)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) Liver diseases caused over 51,600 deaths in the USA in 2020 (American Liver Foundation). It is estimated that 25% of the adult population in the country has liver disease, with the most common diagnosis of fatty liver that includes nonalcoholic steatohepatitis (NASH), along with viral and alcoholic chronic liver disease. The liver also experiences hepatic ischemia/reperfusion injury during major liver surgery and liver transplantation, as well as liver damage during sepsis and other inflammatory disease states. Human liver tumor cell lines or animal liver cells are not good models to mimic primary human liver cell response to pathophysiologic disease states. Our overall goal of the Human Liver Tissue & Hepatocytes Research Resource (HLTHRR) program is to provide normal human liver tissue and normal human hepatocytes (HC) and non-parenchymal cells (NPC) including NPC sub-fractions (Kupffer cells, sinusoidal endothelial cells, cholangiocytes, and stellate cells) to biomedical researchers across the USA to study acute and chronic liver diseases to improve public health.

PI_NAMEs: GELLER, DAVID A (contact);MONGA, SATDARSHAN SINGH;SOTO-GUTIERREZ, ALEJANDRO

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acceleration;acute liver disease;Administrative Supplement;Adult;Alcoholic Hepatitis;American;Animals;Biliary;Biomedical Research;biomedical resource;Cell Culture Techniques;Cell Fraction;Cell Separation;Cells;Cessation of life;cholangiocyte;chronic liver disease;Communities;Contracts;Country;Data;Diagnosis;Disease;drug discovery;Drug or chemical Tissue Distribution;Endothelial Cells;Enzymes;Excision;experience;Fatty Liver;Feedback;Foundations;Funding;Goals;Hepatocyte;Human;Human Resources;improved;Inflammatory;innovation;Knowledge;Kupffer Cells;Label;Leadership;Liver;Liver diseases;liver function;liver injury;liver ischemia;Liver neoplasms;liver transplantation;Metabolic;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;nonalcoholic steatohepatitis;Normal Cell;Operative Surgical Procedures;organizational structure;Pathology;Patients;Physiology;Population;problem drinker;Process;programs;Public Health;Publications;R24;Regenerative capacity;Reperfusion Injury;Research;Research Personnel;Resected;Resources;response;Scientist;Sepsis;Services;Shipping;Source;stellate cell;success;Surveys;Suspensions;System;Tissues;Toxicology;Translational Research;tumor;Tumor Cell Line;United States National Institutes of Health;Universities;Viral;Viral hepatitis;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (J1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE DNA methylation regulates pluripotency, differentiation and tissue-specific gene expression thus playing a key role in normal development. Dnmt3b is a critical DNA methyltransferase involved in epigenome remodeling soon after conception. Understanding molecular mechanisms utilizing various Dnmt3b activities in embryogenesis, postnatal development and in assisted reproductive technologies will provide fundamental knowledge about processes governing mammalian development and may lead to new therapeutic strategies in the future.

PI_NAMEs: OPAVSKY, RENE  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Assisted Reproductive Technology;Cells;Centromere;Complex;Conceptions;Data;demethylation;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3B gene;Embryo;Embryonic Development;Enzymes;Epiblast;Epigenetic Process;epigenome;Family;Fertilization in Vitro;Future;Gene Expression;Gene Expression Regulation;Genes;Genome;genome wide methylation;genomic locus;Genomic Segment;Human;Human Cell Line;implantation;imprint;in vivo;Individual;Knowledge;Mediating;Methylation;methylation pattern;Modification;Molecular;Molecular Analysis;mouse development;Mouse Embryonic Stem Cells;Mus;novel therapeutic intervention;Pathogenesis;Physiological;Play;pluripotency;postnatal development;Pre-implantation Embryo Development;prenatal;Preventive care;Process;Proteins;recruit;Role;Techniques;Testing;Time;Tissue-Specific Gene Expression;Tissues;Transcriptional Regulation;X Inactivation

PROJECT_TITLE: Dnmt3b activities in mouse development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Sarcoidosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Sarcoidosis is a systemic immune mediated disease that has an unknown etiology, and is currently treated with broadly acting immunosuppressive therapy that can result in significant toxicity. Studies have identified independent associations between sarcoidosis and genetics, immunity, and demographics, but there have been few integrative analyses of these factors. The proposed project will: (1) help characterize immunological profiles associated with and predictive of sarcoidosis disease severity, while accounting for non-immune risk factors, (2) will provide insight that can aid in identifying high risk patients and decision making regarding appropriate use of therapeutics, and (3) will set the foundation for follow-up studies on the development of targeted therapeutics for sarcoidosis patients.

PI_NAMEs: KOTH, LAURA L (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Activities of Daily Living;adaptive immunity;Affect;Age;Antibodies;Antigens;Binding;biomarker identification;Black race;black women;Blood;blood-based biomarker;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;Chronic;Clinical;Clinical Data;clinical decision-making;Clinical Markers;clinical predictors;Constitution;Data;Decision Making;Demographic Factors;demographics;Development;Disease;Disease Progression;Ensure;Estrogens;Etiology;experience;Factor Analysis;Fibrosis;follow-up;Follow-Up Studies;Foundations;Genetic;Guidelines;health disparity;high risk;hospitalization rates;Human;idiopathic pulmonary fibrosis;IL17 gene;Immune;Immune system;Immunity;Immunologic Factors;Immunologics;Immunophenotyping;Immunosuppressive Agents;Impairment;improved;in vitro Assay;Influenza A virus;insight;Integration Host Factors;Interstitial Lung Diseases;Intervention;Investigation;Lead;Leukocytes;Ligands;Lipopolysaccharides;Lung;Lung Transplantation;Lymphocyte Function;Mediating;microbial;Modeling;Mus;mycobacterial;Natural Immunity;Organ;Outcome;parent project;Parents;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patient Care;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Poly I-C;Population;predictive marker;Predisposition;Production;profibrotic cytokine;programmed cell death protein 1;Pulmonary Fibrosis;pulmonary function;Pulmonary Sarcoidosis;recruit;Resolution;Risk Factors;Role;Sampling;Sarcoidosis;Scleroderma;Severities;Severity of illness;sex;side effect;Signal Transduction;Smoking;Socioeconomic Status;Specimen;standard of care;STAT3 gene;Stimulus;T-Cell Receptor;T-Lymphocyte;targeted treatment;Therapeutic;Therapeutic immunosuppression;therapeutic target;Therapeutic Uses;Toll-like receptors;tool;Toxic effect;Transfection;Transforming Growth Factor beta;Treatment Efficacy;Up-Regulation;Work

PROJECT_TITLE: Longitudinal acquisition of immune signatures for pulmonary sarcoidosis - UMB DS


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Genetics;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Palliative Care;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_NAME: CELLFORMA, INC

PHR: PROJECT NARRATIVE IPF is a terminal lung disease causing 40,000 deaths in the US each year, with a life expectancy of three to five years. Cell replacement therapy to regenerate IPF lungs is a potential curative solution, but we cannot generate the lung cells needed in a scalable and cost-effective way. Cellforma is creating an AI/ML platform to overcome this challenge to develop curative, first-in-class, cell replacement therapy for IPF.

PI_NAMEs: IETSWAART, JALDERT HUGO RIGOBERT (contact)

PROJECT_TERMS: activin A;AGTR2 gene;Alveolar;Animal Model;Antibiotics;Architecture;Artificial Intelligence;Artificial Intelligence platform;Benchmarking;Beta Cell;Biotechnology;BMP4;Boston;cell behavior;cell replacement therapy;Cell Reprogramming;Cell Therapy;Cell Transplantation;cell type;Cells;Cessation of life;Chemical Structure;Chemicals;Cicatrix;Coculture Techniques;cost;cost effective;Data;Deposition;Dermal;Deterioration;Development;Diagnosis;drug development;drug repurposing;effectiveness validation;Engraftment;epithelial stem cell;Epithelium;FGF7 gene;Fibroblasts;Freezing;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;Genetic Engineering;Graph;graph neural network;Growth;Growth Factor;Human;idiopathic pulmonary fibrosis;in silico;In Vitro;induced pluripotent stem cell;Inflammation;Insulin-Dependent Diabetes Mellitus;interest;Karyotype determination procedure;Knowledge;knowledge graph;Learning;Life Expectancy;Literature;Lung;Lung Diseases;lung failure;Lung Transplantation;Machine Learning;Maps;Methods;mouse model;Mus;Natural regeneration;novel;Organ;Organ Donor;Palliative Care;Patients;Pharmaceutical Preparations;Phase;programs;Proteins;Proteomics;Protocols documentation;public database;Pulmonary Fibrosis;regenerative cell;Reporting;Severity of illness;single-cell RNA sequencing;Skin;Small Business Innovation Research Grant;small molecule;Somatic Cell;Supporting Cell;Testing;therapeutic target;Tissues;Training;transcriptome sequencing;Transplantation;tumor;Validation;Viral Vector

PROJECT_TITLE: Development of Novel Regenerative Cell Therapies for Lung Diseases using AI-guided Chemical Reprogramming of Human Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Hepatitis B virus (HBV) chronically infects about 250 million people with annual 1 million deaths worldwide. The search for a cure of chronic hepatitis B has been hampered by the lack of small animal models of HBV infection and replication. The overall goal of this application is to develop murine models of HBV infection and replication for the study of HBV infection, replication, pathogenesis, and carcinogenesis. More importantly, murine models of HBV infection will foster discovery and development of more effective antiviral drugs towards a cure of chronic hepatitis B.

PI_NAMEs: LUO, GUANGXIANG GEORGE (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acute;Acute Hepatitis;Affect;Animals;Anti-viral Agents;Anti-viral Therapy;Apolipoprotein E;apolipoprotein E-3;B-Lymphocytes;carcinogenesis;Cell Culture System;Cell Culture Techniques;Cells;Cessation of life;Child;Chronic;Chronic Hepatitis;Chronic Hepatitis B;Circular DNA;Cirrhosis;Crossbreeding;Data;Development;drug development;drug discovery;Drug Targeting;Evaluation;Female;Fostering;Genetic Transcription;Genome;Goals;HBV Animal Model;Heparan Sulfate Proteoglycan;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Vaccines;Hepatitis B Virus;Hepatocyte;Human;Immune;Immune response;Immunocompetent;immunodeficiency;immunodeficient mouse model;immunoglobulin B;Immunotherapy;In Vitro;in vivo;Infection;Infectious hepatitides;Injections;Integration Host Factors;Interferons;Investigation;Knock-out;Knockout Mice;Licensing;Life;Liver diseases;Liver Fibrosis;Low Density Lipoprotein Receptor;male;milliliter;Modeling;Mothers;mouse model;Mus;Na(+)-taurocholate-cotransporting peptide;Neonatal;neonatal hepatitis;novel;novel therapeutic intervention;nucleoside analog;Nucleosides;nucleotide analog;offspring;Outcome;Pathogenesis;Persons;Play;Predisposition;prevent;Primary carcinoma of the liver cells;Proprotein Convertases;Protein Family;Protein Isoforms;Public Health;receptor;receptor binding;Reporting;Research;Role;Subtilisins;T-Cell Depletion;T-Lymphocyte;Therapeutic;Transgenic Mice;Transgenic Organisms;transmission process;Tropism;Vaccines;Vero Cells;viral DNA;Viral hepatitis;Viremia;Virus Diseases;Virus Receptors;Virus Replication;Woodchuck;Woodchuck Hepatitis B Virus

PROJECT_TITLE: Novel mouse models of hepatitis B virus infection and replication

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 DF-M (M1)]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The onset of the global pandemic of coronavirus disease 2019 elevated the importance of accurate predictive modeling of disease transmission. The proposed research aims to develop a framework of pandemic predictive intelligence that can adapt over time to changing data quality and evolving behavioral and environmental characteristics that influence disease transmission. To ensure the broader impact of the proposed research, we will develop, validate, and evaluate methodology and software for pandemic forecasting, real-time monitoring, mitigation, and prevention of the spread of pathogens using national county/city-level data from the US Department of Health and Human Services, Department of Microbiology at the University of Pennsylvania, and other publicly available data resources.

PI_NAMEs: HUANG, JING  (contact);RUBIN, DAVID M.

PROJECT_TITLE: Characterizing dynamics of pandemic and preparing for speedy and accurate response


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative In this project we will determine the roles of specialized white blood cells, called tumor-specific T cells, in promoting an immune response against tumors in mice and determine their potential for use in cancer immunotherapy. We hypothesize that transfer of modified tumor-specific T cells will eradicate large established tumors and prevent recurrence of antigen-loss-variant tumors, due to their ability to 1) directly kill the tumor cells; 2) induce intratumor release of type I IFNs to promote host antitumor immune responses; and 3) effectively eradicate large established tumors in vivo in both mouse and human.

PI_NAMEs: LU, YONG  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adenosine;Adoptive Cell Transfers;Adoptive Transfer;anti-tumor immune response;Antigens;antitumor effect;Antitumor Response;B-Lymphocytes;cancer cell;cancer immunotherapy;CD19 Antigens;CD19 gene;CD22 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;cell injury;Cell Lineage;Cells;chimeric antigen receptor T cells;Clinical Research;Clinical Trials;Color;cost;Darkness;Data;Disease remission;Down-Regulation;efficacy evaluation;Endowment;experience;extracellular;Extracellular Space;Foundations;Future;Glioblastoma;Growth;Human;humanized mouse;Immune;Immune response;immunogenic;Immunotherapy;in vivo;Inflammatory;innovation;Interferons;Knock-out;leukemia;Leukocytes;Lymphoma;Malignant Neoplasms;Mediating;Melanins;Melanoma;Modeling;monocyte;mouse model;MS4A1 gene;Multiple Myeloma;Mus;Mutation;Myeloid Cells;neoplastic cell;novel;Pathway interactions;Patients;pre-clinical;prevent;Production;Purinoceptor;recruit;Recurrence;Recurrent tumor;Relapse;Resistance;response;Role;Site;Solid Neoplasm;Stress;Surface;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Toxic effect;Translating;tumor;tumor eradication;Tumor Immunity;Tumor Tissue;Tyrosinase related protein-1;Variant;Work

PROJECT_TITLE: Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project addresses two key areas of primary importance in our understanding of bacteria physiology: cell wall biogenesis and bacterial cell surface accessibility in Gram-positive bacteria. We have developed a novel approach aimed at capturing and unveiling these key bacterial cell surface features using unnatural building blocks that mimic cell wall components.

PI_NAMEs: PIRES, MARCOS M. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Unraveling Bacterial Cell Wall Biosynthesis and Sensing via Synthetic Analogs

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of heart failure in the U.S. and is associated with high morbidity and mortality. Leveraging an existing database of cardiac magnetic resonance images in a cohort of well-phenotyped patients with HFpEF and age- and sex-matched healthy controls, we propose a novel Single Image Multi-endPoint anaLysis (SIMPL) approach for comprehensive evaluation of pathophysiologic mechanisms driving HFpEF.

PI_NAMEs: NELSON, MICHAEL DOUGLAS (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Activities of Daily Living;Age;aging population;Aorta;Area;Automobile Driving;biobehavior;cardiac magnetic resonance imaging;Clinical;cohort;Communities;Data;Data Set;Databases;Diabetes Mellitus;Diagnosis;Disease;effective therapy;EFRAC;Evaluation;exercise intolerance;Exercise Tolerance;experimental study;Fatty acid glycerol esters;Functional disorder;Funding;Future;Group Meetings;Heart failure;heart failure with reduced ejection fraction;heart function;human data;Hypertension;Image;Image Analysis;Individual;innovation;Investigation;Left atrial structure;Left ventricular structure;Malignant Neoplasms;Methods;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Multivariate Analysis;Myocardium;National Heart, Lung, and Blood Institute;Nature;novel;Obesity Epidemic;Organ;Patient Outcomes Assessments;Patients;Pericardial body location;Phenotype;Positioning Attribute;preservation;Prevalence;prevent;Prognosis;Public Health;Quality of life;Research;Research Methodology;Research Priority;Resolution;Right atrial structure;Right ventricular structure;secondary analysis;sex;Study Section;Survival Rate;Therapeutic;Tissues;tool;United States;Validation;working group

PROJECT_TITLE: Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Agent Orange & Dioxin;Contraception/Reproduction;Endocrine Disruptors;Endometriosis;Genetics;Pain Research;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Endometriosis is a persistent and enigmatic gynecologic disease that affects approximately 10-15% of reproductive-aged women. The proposed research seeks to uncover mechanisms by which altered immune cell function potentially leads to uterine dysfunction and peritoneal inflammation as seen in women with endometriosis. We expect to identify an immunologic “footprint” of endometriosis which should foster the development of intervention and prevention strategies by using immune cells as diagnostic/ therapeutic tools.

PI_NAMEs: STEPHENS, VICTORIA RENEE (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;aged;Animals;Anti-Inflammatory Agents;Area;Benign;Bone Marrow;career;Cell Physiology;Cells;Characteristics;Chronic;combat;Communication;Critical Thinking;Data;Data Analyses;debilitating pain;Development;Diagnostic;Dioxins;Disease;disease phenotype;Dysmenorrhea;Dyspareunia;Endocrine;Endocrine disruption;Endocrine Disruptors;Endometrial;endometriosis;Endometrium;Epigenetic Process;Estradiol;Etiology;Exhibits;experience;Exposure to;Fellowship;Female Genital Diseases;female reproductive tract;Formulation;Fostering;Functional disorder;functional status;Generations;Genes;Genetic Predisposition to Disease;Gland;Goals;Growth;Gynecologic;Human;human tissue;Immune;Immunologic Surveillance;Immunologics;Immunophenotyping;Immunotoxicology;improved;in utero;In Vitro;Incidence;Infection;Infectious Agent;Infertility;Inflammation;Inflammatory;Inflammatory Response;International;Intervention;intraperitoneal;Knowledge;Laboratories;Learning;Life;Link;Macrophage;Manuscripts;Mediating;member;Memory;Metabolic;migration;Molecular;mouse model;Mucous Membrane;Mus;Onset of illness;Pathogenesis;Pathway interactions;Peritoneal;Phenotype;Positioning Attribute;post-doctoral training;prenatal exposure;Prevention strategy;Process;Progesterone;protein expression;Quality of life;receptor expression;reproductive;Reproductive Endocrinology;Reproductive Immunology;Research;Research Personnel;Resistance;response;Retrograde Menstruation;Role;Scientist;Site;skills;stem cells;Stimulus;System;Technical Expertise;Technology;Tetrachlorodibenzodioxin;theories;Therapeutic;therapeutic target;therapy development;Tissues;tool;toxicant;Toxicant exposure;Toxicology;Training;Uterine cavity;Uterus;Woman;Work

PROJECT_TITLE: Immunologic Contributions to the Endometriosis Phenotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Precision Medicine;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Obstructive sleep apnea (OSA) is a serious health concern that is inadequately treated with existing therapies. Falling “drive-to-breathe” during sleep is implicated as causing events in most patients (60%, i.e. “drive- dependent” subtype). The proposed mechanistic research studies will 1) critically-test the role of falling ventila- tory drive in OSA through its physiological mitigation in sleeping patients, 2) examine whether mitigating venti- latory drive reduction with acetazolamide—a promising OSA intervention for many patients—is most effica- cious in “drive-dependent” OSA, 3) providing a means to identify the drive-dependent patients who will benefit most.

PI_NAMEs: SANDS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Acetazolamide;Air Movements;airway obstruction;Breathing;Carbon Dioxide;Caring;Characteristics;Clinical;clinical application;clinically relevant;Compensation;Continuous Positive Airway Pressure;Cross-Over Trials;Data;Development;Dilator;Disease;Dose;Esophagus;Etiology;Event;Exhibits;falls;Functional disorder;genioglossus muscle;Health;improved;Individual;Intervention;Knowledge;Left;Legal patent;Measurement;method development;Methods;Modeling;Muscle;Muscle Tonus;neural;novel therapeutic intervention;Observational Study;Obstruction;Obstructive Sleep Apnea;open label;Outcome;Patient Selection;Patients;personalized intervention;Pharmacotherapy;Pharyngeal structure;pharynx muscle;Phenotype;Physiological;Placebo Control;Play;Polysomnography;precision medicine;prevent;prospective;prospective test;Randomized;research study;respiratory;Respiratory Diaphragm;response;Rest;Risk;Role;Shapes;Signal Transduction;Sleep;standard measure;Stimulant;Subgroup;Testing;Therapeutic;Time;Translating;Treatment Efficacy;ventilation;Work

PROJECT_TITLE: Role of ventilatory drive in obstructive sleep apnea: An avenue for precision intervention

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Gene Therapy;Genetics;Hematology;Immunotherapy;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSICS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE High-throughput single-cell RNA sequencing offers unprecedented opportunities for understanding the biology of cell differentiation. This project will use single-cell data in in-silico experiments to identify new drug targets and generate new hypotheses for pre-clinical investigation. Our goals are: (1) control of angiogenesis, a process involved in many ischemic, inflammatory, infectious, and immune disorders, and (2) new schemes for direct reprogramming of lymphocytes from induced pluripotent stem cells.

PI_NAMEs: PIERMAROCCHI, CARLO  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adult;Affect;Age related macular degeneration;angiogenesis;Angiogenesis Inhibition;Arthritis;Biological;Biological Process;Biomanufacturing;Blindness;Blood Vessels;Brain;Cancer Vaccine Related Development;CAR T cell therapy;Cell Differentiation process;Cells;Cellular biology;chimeric antigen receptor T cells;clinical investigation;Communicable Diseases;Communities;Data;deep learning;design;Development;Disease;Embryonic Development;Evolution;experimental study;gene network;Genes;Goals;Health Sciences;Hematopoiesis;Homeostasis;Immune System Diseases;in silico;induced pluripotent stem cell;Inflammatory;innovation;Investigation;Ischemia;Knowledge;Lymphocyte;machine learning method;Malignant Neoplasms;Maps;mathematical model;Mathematics;Memory;Modeling;network models;new therapeutic target;novel therapeutics;Organ;Pathway interactions;Patients;Pattern;Phenotype;Play;pre-clinical;Process;Production;Psoriasis;Research;Retina;Scheme;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Software Tools;System;tissue repair;Training;transcriptomics

PROJECT_TITLE: Network models of differentiation landscapes for angiogenesis and hematopoiesis


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: Narrative Bone marrow failure syndromes are fatal if untreated and current therapies and strategies that prolong and improve survival outcomes are desperately needed. We will investigate how improving inflammation resolution programs can be leveraged as a new therapy for treating bone marrow failure. Our work is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge about the behavior of living systems to enhance health, lengthen life, and reduce the burdens of illness.

PI_NAMEs: MACNAMARA, KATHERINE C. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: acquired bone marrow failure;Address;aged;Alternative Therapies;Aplastic Anemia;Autoimmune Diseases;Behavior;Biological;Biological Assay;Blood;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;burden of illness;CD47 gene;cell injury;Cell Surface Receptors;Cells;Chronic;Data;Disease;Effectiveness;Elderly;Equilibrium;Failure;Generations;GPR18 receptor;Health;Hematopoietic;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Host Defense;Human;human disease;Immune;Immunosuppression;Impairment;improved;Infection;Inflammation;Inflammation Process;Inflammatory;Inflammatory Response;insight;Kinetics;Knowledge;Leukotrienes;Life;lipid mediator;Macrophage;Marrow;Mediating;Mediator;Mission;Molecular;mortality;mouse model;Mus;Natural regeneration;new therapeutic target;novel;novel strategies;novel therapeutics;older patient;Omega-3 Fatty Acids;Organism;Outcome;Pathogenesis;Pathway interactions;Patients;Physiological;Predisposition;prevent;Production;programs;Prostaglandins;PTPNS1 gene;receptor;receptor expression;Recovery;Refractory;reparative process;Resolution;Role;Series;standard of care;stem cell function;survival outcome;Testing;Therapeutic;Therapeutic immunosuppression;Time;Transgenic Mice;Transplantation;transplantation therapy;United States National Institutes of Health;Work

PROJECT_TITLE: Improving Inflammation Resolution to Mitigate Acquired Bone Marrow Failure

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging

ORG_CITY: GALVESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE The proposed program for Hispanic and other Minority Health and Aging aims to increase and improve the pool of researchers with expertise to address challenges raised by the growing diversity in aging of the United States population. In this coordinated program for training predoctoral students and post-doctoral fellows, participating faculty mentors have a long-term research agenda and expertise in population-based research on Hispanic aging with a wide multidisciplinary perspective.

PI_NAMEs: DOWNER, BRIAN GREGORY (contact);MEHTA, NEIL

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Health;Minority

PROJECT_TITLE: Health of Older Minorities


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: To understand complex biological systems, it would be crucial to be able to monitor a large number of interacting species with high spatiotemporal resolution, but the current technology (including omics and microscopy) have fundamental limitations in addressing this challenge. We propose a fundamentally novel spectroscopy and microscopy platform towards massively multiplex optical imaging. This general technology could transform our understanding of complex systems and could also lead to more accurate diagnosis of diseases. 1

PI_NAMEs: MIN, WEI  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Architecture;Biological;biological systems;Brain imaging;Brain Mapping;cell type;Cells;Color;Complex;complex biological systems;Confocal Microscopy;Data;design;Development;disease diagnosis;Electronics;Fluorescence;Fluorescence Microscopy;Image;image archival system;imaging probe;Imaging technology;in vivo;innovation;Length;light microscopy;Microscopy;Monitor;multiplexed imaging;Nature;new technology;novel;optical imaging;Optics;Organ;Organelles;Pathology;Phenotype;protein complex;Proteins;Raman Spectrum Analysis;Resolution;Sampling;single molecule;spatiotemporal;Specimen;Spectrum Analysis;System;Techniques;Technology;technology platform;temporal measurement;Time;Tissues;two-dimensional;two-photon;ultra high resolution

PROJECT_TITLE: Super-multiplex optical imaging: development of novel spectroscopy and probes to illuminate complex biomedicine


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative We propose to develop a new microscope capable of live superresolution imaging. This microscope will make it possible to image dynamic subcellular processes with 80 nm resolution, allowing biologists to study evolving processes within live cells and tissue sections. By allowing biologists to gain a better understanding of the dynamics of subcellular structures, this project will help elucidate the mechanisms of disease.

PI_NAMEs: KNER, PETER ALEXANDER (contact)

PROJECT_TERMS: 3-Dimensional;Actins;adaptive optics;Area;biological research;Biological Sciences;Biology;Cell Physiology;Cells;Cellular Structures;Chromosome Pairing;Color;Dendrites;design;Development;Disease;Equipment;Filopodia;Generations;Goals;Heterochromatin;Image;imaging facilities;instrument;interest;Label;Lamins;Lateral;Light;light intensity;light transmission;Lighting;Maize;Measurement;Meiosis;meter;Methods;Microscope;Microscopy;Microtubules;Mitochondria;Modeling;novel;novel strategies;Nuclear Pore;Nuclear Pore Complex;Optics;Pattern;Performance;Peripheral;Phase;Process;Proteins;rapid technique;reconstruction;Resolution;Sampling;Scanning;single molecule;Speed;Spottings;Structure;Subcellular structure;superresolution imaging;System;Techniques;Thinness;three dimensional structure;Three-Dimensional Imaging;Tissues;tool;two-dimensional;ultra high resolution;Vesicle;X Inactivation

PROJECT_TITLE: Three-dimensional Nonlinear Structured Illumination for Live Imaging with 80 nm resolution

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Veterans who suffer strokes often have disturbances in the ability to walk that reduces independence and quality of life. Alterations in gait combined with general decreased activity are associated with reduced muscle strength of the paretic leg. This leads to cardiovascular deconditioning and reduced quality of life. There is a new and novel battery powered device (Keeogo powered orthotic exoskeleton) that uses motors that assist knee movement while walking, sitting down, and standing up. The Keeogo monitors hip movement to assist the knee, making it simple to learn how to use. If successful, this project will show how this device will help improve the ability to walk and provide evidence to support larger clinical trials in a home and community setting to improve mobility, increase muscle mass and strength in the legs, as well as improve general health and quality of life. Lastly, this device could be used to increase motivation and confidence in a person to walk for longer periods of time and distance, providing the ability to walk in places that were previously inaccessible.

PI_NAMEs: SPUNGEN, ANN MICHELE (contact)

PROJECT_TERMS: Acclimatization;Activities of Daily Living;Affect;Articular Range of Motion;Biomechanics;Body Composition;Bone Density;Cardiovascular Deconditioning;Cardiovascular Physiology;Carpet;chronic stroke;Clinical Trials;clinically significant;Clothing;Communities;community setting;Competence;Control Groups;cost;Development;Devices;Educational Intervention;efficacy evaluation;Energy Metabolism;Environment;Equity;exoskeleton;FDA approved;foot;functional improvement;Future;Gait;Gait abnormality;gait rehabilitation;Health;Hip Joint;Hip region structure;Home;Hour;improved;improved mobility;independent ambulation;instrument;Intervention;Intuition;Investigation;joint mobilization;Joints;Knee;Knee joint;Learning;Leg;leg paresis;Limb structure;Lower Extremity;Maps;Measurement;Measures;medical complication;Metabolic;Monitor;Motivation;Motor;Movement;muscle form;muscle strength;novel;Orthotic Devices;Outcome;Outcome Measure;Oxygen Consumption;Paresis;Participant;Patients;Persons;Phase;Pilot Projects;portability;post stroke;powered exoskeleton;pressure;Quality of life;Randomized;recruit;Recurrence;reduced muscle strength;Rehabilitation Centers;Rehabilitation therapy;Research;Rotation;Secondary to;SF-36;skills;Spinal cord injury;Stroke;stroke survivor;Structure;System;Testing;Time;Training;Training Programs;Veterans;Visit;Walking;Weight;Work

PROJECT_TITLE: Use of a Powered Orthotic Exoskeleton to Promote Mobility Through Improved Squat, Knee Flexion and Loading of the Paretic Leg in Persons with Chronic Stroke

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Osteoarthritis;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative Cell-based therapies for cartilage injury and osteoarthritis rely largely on in vitro engineering of replacement cartilage from mesenchymal progenitors, but are plagued by the instability of the cartilage cell (chondrocyte) phenotype: mammalian stem-cell derived chondrocytes tend to either hypertrophy or dedifferentiate when implanted into a patient. However, cartilaginous fishes (sharks, skates, and rays) possess a skeleton that is composed entirely of pre-hypertrophic cartilage, and that remains cartilaginous throughout life. In this study, I will use single-cell RNA-sequencing and comparative genomics to identify gene expression correlates of permanent pre-hypertrophic cartilage in the skate (Leucoraja erinacea), and use skate-inspired molecular manipulations to achieve and optimize a stable chondrocyte cell state from mammalian mesenchymal progenitors.

PI_NAMEs: PALMER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adult;Age;articular cartilage;ATAC-seq;Biological;Biological Models;bone;bone loss;calcification;Cartilage;cartilage cell;cartilage development;Cartilage injury;cartilaginous;Cell Therapy;Cells;Chondrichthyes;Chondrocytes;Collagen Fiber;Collagen Type I;Collagen Type II;comparative genomics;CRISPR/Cas technology;Degenerative polyarthritis;Development;differential expression;differentiation in vitro;Elderly;embryo tissue;Embryonic Development;Engineering;Enhancers;Evolution;Fibrocartilages;Fishes;Frequencies;Friction;gene discovery;Gene Expression;Gene Transfer Techniques;Genes;Genetic Transcription;genome annotation;genome editing;Genomic approach;Genomics;Growth;healing;Health;Human;Hyaline Cartilage;Hypertrophy;Implant;implantation;improved;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Inferior;Injury;Joints;Knee;Laboratories;Left;Lesion;Life;Mammals;marine;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Minor;Molecular;Nature;novel;novel strategies;Organism;osteogenic;Overweight;Pain;Pathology;Patients;Phenotype;Physiologic Ossification;Population;Prevalence;Process;Property;Quality of life;repaired;Research;Resources;Shark;single-cell RNA sequencing;Site;skeletal;Skeletal Development;skeletogenesis;Skeleton;Stable Populations;stem cell based approach;stem cells;Structure;Techniques;Testing;Thinness;Time;Tissue Engineering;Tissues;Transplantation;treatment strategy;Untranslated RNA;Variant;Vertebrates;Weight-Bearing state

PROJECT_TITLE: Molecular control of chondrocyte hypertrophy: an evolutionary approach


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Mental Health;Natural Products;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative. The proposed research is relevant to public health because the development of novel chemistry to synthesize small molecules with new core structures is critical to the discovery of new leads for drug discovery. As such, the experiments described in this proposal are relevant to the NIH’s mission because they will enable the discovery of previously inaccessible molecules with the potential to become new medicines that will "enhance health, lengthen life, and reduce illness and disability."

PI_NAMEs: SHAW, JARED THOMAS (contact)

PROJECT_TERMS: Acute Disease;Address;Alkaloids;Architecture;Area;carbene;catalyst;Chemicals;Chemistry;Chronic Disease;Complex;Custom;cycloaddition;design;Development;diene;disability;drug discovery;experimental study;Goals;Health;innovation;Legal patent;Life;Medicine;Mental Depression;Metals;Methodology;Methods;Mission;Modeling;molecular assembly/self assembly;Natural Products;Nervous System Disorder;Neuronal Plasticity;next generation;novel;novel therapeutics;Organic Chemistry;Pharmacologic Substance;Post-Traumatic Stress Disorders;Process;programs;Public Health;Reaction;Research;Rhodium;small molecule;Societies;Structure;Time;Translating;United States National Institutes of Health

PROJECT_TITLE: Studies in the Synthesis of Complex Organic Molecules with Donor-Donor Carbenes


NIH_SPENDING_CATS: Genetics;Pediatric;Rare Diseases

ORG_CITY: GREENWOOD

ORG_NAME: GREENWOOD GENETIC CENTER

ORG_STATE: SC

PHR: PROJECT NARRATIVE The Congenital Disorders of Glycosylation (CDG) are a group of inherited diseases caused by mutations in genes involved in protein and lipid glycosylation. We are using CDG zebrafish models to understand how altered glycosylation causes disease symptoms with the idea that this information will point to new therapies for these diseases.

PI_NAMEs: FLANAGAN STEET, HEATHER R (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Affect;Aldehyde Reductase;Automobile Driving;Biosensor;Cartilage;cartilage development;Cell Adhesion Molecules;Cellular Stress;Chondrocytes;Chondrogenesis;Clinical;Complex;Congenital disorders of glycosylation;Defect;Development;Disease;disease phenotype;Embryo;Enzymes;Evaluation;FRAP1 gene;Functional impairment;Genes;Genetic;glycosylation;Goals;Grant;Guanosine Diphosphate Mannose;Hereditary Disease;Image;Impairment;In Situ;In Vitro;Individual;inhibitor;insight;Light;Link;Lipids;mannose 1-phosphate;mannose 6 phosphate;Matrix Metalloproteinases;Metabolic dysfunction;Metabolism;metabolomics;Modeling;Molecular;mutant;Mutation;N-Cadherin;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphomannomutase;polyol;Polysaccharides;prevent;Process;Production;Proprotein Convertases;Protein Glycosylation;Proteins;Rare Diseases;Role;Severity of illness;Sorbitol;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stress;Substrate Specificity;sugar;sugar nucleotide;Symptoms;System;Testing;therapy development;tool;Toxic effect;Transgenic Organisms;Work;Zebrafish

PROJECT_TITLE: Pathogenic Mechanisms of Congenital Disorders of Glycosylation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Immunization;Menopause;Neurodegenerative;Neurosciences;Obesity;Osteoporosis;Prevention;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT SUMMARY  We have identified follicle stimulating hormone (FSH) as a new target for treating Alzheimer’s disease, along with three other crippling diseases of the aging population, namely osteoporosis, obesity and high cholesterol. For this, we have designed a lead therapeutic antibody to FSH, which we will take through early stage development in this proposal. This should provide us with critical pieces of information on the likely dose, route and frequency of administration, allowing it to move through the late stage development pipeline into clinical trials.

PI_NAMEs: YUEN, TONY ;ZAIDI, MONE  (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: 1 year old;18 year old;3xTg-AD mouse;absorption;Acute;Affect;Affinity;African;age related;aged;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amino Acids;Amyloid beta-Protein Precursor;Antibodies;Articulation;Asparagine;Binding;Biotechnology;Blocking Antibodies;Body fat;bone;bone loss;bone mass;Brain;Businesses;Bypass;cell bank;Cercopithecus tantalus;Cholesterol;Clinical;Clinical Trials;Cognition;Complex;Computer Models;Coupled;Cyclic GMP;Data;Dementia;design;Development;Discipline;Disease;Disparate;dosage;Dose;Drug Kinetics;efficacy evaluation;efficacy testing;Elderly man;Elderly woman;Endocrinology;Endopeptidases;energy balance;Energy Metabolism;Epitopes;Estrogen decline;Estrogen Replacements;Estrogens;Evaluation;Excretory function;Fatty acid glycerol esters;Female;first-in-human;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;Formulation;Frequencies;Goals;Gonadal structure;good laboratory practice;Health Hazards;Hippocampus;Hormone use;Hormones;Human;humanized antibody;humanized monoclonal antibodies;humanized mouse;hypercholesterolemia;Impaired cognition;improved;In Vitro;individual patient;knock-down;Label;Lead;lead candidate;Life;Longitudinal Studies;loss of function;male;manufacture;manufacturing scale-up;Medical;Medicine;men;Menopause;Metabolism;mild cognitive impairment;Monkeys;mouse model;Mus;Neurosciences;novel;novel therapeutics;Obesity;Organ;Osteoporosis;Ovariectomy;Pathogenesis;Perimenopause;Personal Satisfaction;Phase;Physiology;Pituitary Hormones;polyclonal antibody;Positron-Emission Tomography;prevent;Prevention;Prevention Protocols;Production;Property;Public Health;receptor;receptor binding;Research;Risk;Rodent;Route;Safety;safety study;safety testing;Science;secretase;Serum;Severities;small hairpin RNA;Structure;Symptoms;tau Proteins;Testing;Textbooks;Therapeutic;Therapeutic antibodies;Thyroid Gland;Thyrotropin;transgenic model of alzheimer disease;Treatment Protocols;Up-Regulation;vervet;Woman;Work

PROJECT_TITLE: A Humanized Monoclonal FSH Blocking Antibody for Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) is among the deadliest blood cancers, affecting 20,000 Americans per year with a 5-year survival rate of only 30%. While engineering cells of the immune system to target cancer is one of the most promising approaches in treatment today, this approach has been difficult to apply in AML due both to lack of specific targets on tumor cells as well as the fact that many tumor cells may not express a single targeted antigen. Here I aim to perform initial development of a new type of engineered cell that can specifically eliminate the relapse-driving residual tumor cells after initial chemotherapy, with the long term goal of achieving more AML cures with lower toxicity than current approaches.

PI_NAMEs: KASAP, CORYNN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Allogenic;American;Antibodies;antibody engineering;antibody immunotherapy;Antibody Therapy;Antigen Targeting;Antigens;Automobile Driving;B lymphoid malignancy;Bispecific Antibodies;Blood;Bone Marrow;Bone Marrow Purging;Cell secretion;Cell Therapy;Cells;cellular engineering;Cessation of life;chemotherapy;chimeric antigen receptor T cells;cytokine release syndrome;Data;design;Development;Disease;Drug resistance;Elements;engineered T cells;Engineering;experience;experimental study;Face;feasibility testing;Future;Genetic Transcription;Goals;Hematologic Neoplasms;Hematology;Hematopoietic Neoplasms;Heterogeneity;Home;Homing;IL3RA gene;Immune system;Immunotherapy;In Vitro;in vivo;in vivo Model;innovation;leukemic stem cell;Malignant Neoplasms;Marrow;Measurable;mouse model;Myeloid Cells;Myelosuppression;Neoadjuvant Therapy;neoplastic cell;next generation;Normal Cell;novel strategies;novel therapeutic intervention;patient derived xenograft model;Patients;Pharmacy facility;Physicians;Population;Positioning Attribute;Relapse;relapse prediction;Reporter;Research;Residual Neoplasm;Residual state;Resistance;Risk;Scientist;small molecule;stem cell niche;Stem cell transplant;success;Surface;Surface Antigens;Survival Rate;Synthetic immunology;System;systemic toxicity;T cell therapy;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Index;therapeutic protein;therapeutic target;therapeutically effective;Toxic effect;Training;tumor;tumor heterogeneity;Work;Xenograft Model

PROJECT_TITLE: Multi-functional cellular therapies to overcome tumor heterogeneity and limit toxicity in acute myeloid leukemia


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The AVRC P30 Core facility serves as a centralized vision research resource in Atlanta where faculty from Emory University, Georgia Institute of Technology, Georgia State University, Morehouse School of Medicine, and The Atlanta Veterans Administration Medical Center can undertake joint studies in vision research. The P30 Core facilitates the research of investigators holding NEI R01 grants by providing access to equipment and services that would not be possible on individual R01 grants. The P30 Core also promotes the research projects of pre- and postdoctoral fellows supported by our NEI Training Grant (T32 EY007092-34), recently renewed for five years (2020-2025) and buttresses active recruitment of new tenure-track research faculty.

PI_NAMEs: PARDUE, MACHELLE T. (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Award;base;Binding;Biochemical;Bioinformatics;Biological Process;Biometry;Cell Culture Techniques;Cloud Computing;Collaborations;Communities;Computer Analysis;Computer software;Confocal Microscopy;Core Facility;Core Grant;Data;data management;Dedications;Discipline;disease model;DNA;Drug Delivery Systems;Electron Microscopy;Electronics;Eligibility Determination;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Equipment;Equity;experimental study;Eye;Faculty;faculty community;Flow Cytometry;fluorescence imaging;Fostering;functional genomics;Funding;fundus imaging;Generations;Genes;Genome;Goals;Grant;High Pressure Liquid Chromatography;Human Resources;Image Analysis;Immunohistochemistry;improved;Individual;Informatics;Injury;Institution;Investigational Therapies;Joints;Lasers;light microscopy;Medical center;Microarray Analysis;Microsurgery;Molecular;Morehouse School of Medicine;morphometry;Mus;Oncology;Ophthalmoscopy;Organism;Peer Review;Peptide Sequence Determination;Phenotype;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;Proteins;Proteomics;Publications;recruit;Recruitment Activity;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Retina;Retinal Degeneration;RNA;Rodent;Scanning;Scientist;Series;service member;Services;small molecule;structural biology;structural imaging;Structure;Technology;tenure track;Tissues;tonometry;Training;Ultrasonography;United States Department of Veterans Affairs;Universities;Vision;Vision research;Western Blotting

PROJECT_TITLE: P30-Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: Narrative sections are not allowed for the Admin, and Cores A, B, and C modules according to PA-20-051.

PI_NAMEs: NICKERSON, JOHN M (contact)

PROJECT_TERMS: Advisory Committees;Area;Authorization documentation;Biochemistry;Biomedical Engineering;Budgets;Cellular biology;chemical safety;Communities;conflict resolution;Core Facility;Core Grant;COVID-19 pandemic;Decision Making;Development;Directories;Electronic Mail;Electronics;Equipment;Equity;Event;Expenditure;flexibility;Genetic;Goals;Grant;IACUC;improved;innovation;Institution;interest;Intranet;Leadership;Link;meetings;member;Mission;Molecular Biology;Monitor;Neurosciences;novel;operation;Performance;Program Description;programs;Research;Research Personnel;Resources;Schedule;Services;symposium;synergism;System;Training;United States National Institutes of Health;Update;Vision;Vision research;vision science;Wages;web site;Work

PROJECT_TITLE: P-30 Core Grant for Vision Research Admin Core


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Hydrogenase enzymes are pervasive in bacteria and archaea, many of which inhabit the human gut and some of which are pathogenic. Elucidating the biosynthesis and mechanisms of hydrogenases underpins strategies for controlling these organisms. Pharmaceutically relevant concepts and strategies result from the study of hydrogenases, the understanding of which has revolutionized the manipulation of the simplest of all molecules, the fuel H2.

PI_NAMEs: RAUCHFUSS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Biosynthesis and Reactivity of the Active Site of the FeFe Hydrogenases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PI_NAMEs: GROSSNIKLAUS, HANS E. (contact)

PROJECT_TERMS: Animal Experiments;Communities;Contrast Media;Core Facility;Core Grant;Data;Data Analyses;Development;Disease;disease model;Drug Delivery Systems;Electron Microscopy;Eye diseases;Eye Neoplasms;Gene Delivery;Genes;Genotype;Goals;Health;Histology;Image;Image-Guided Surgery;Imaging Device;Imaging Techniques;Injury;Laser Scanning Confocal Microscopy;Laser Scanning Microscopy;Magnetic Resonance Imaging;member;morphometry;Nerve Degeneration;Oncology;Optic Nerve;Proteins;Research Project Grants;Resolution;Retina;Retinal Degeneration;Services;structural biology;structural imaging;Structure;superresolution microscopy;Tissue imaging;Tissues;Universities;Vision research

PROJECT_TITLE: P30-Core Grant for Vision Research Core A


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Neurosciences;Pain Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Treatments are needed to improve affective function in patients with comorbid chronic low back pain and depression. Psilocybin is a non-opioid therapeutic that has already demonstrated efficacy for the treatment of depression and holds promise for use as a pain management medicine. This project will test the effect of psilocybin on affective function in patients with comorbid chronic low back pain and depression.

PI_NAMEs: FINAN, PATRICK ;YADEN, DAVID BRYCE (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: active control;Address;Affect;Affective;Aftercare;Amygdaloid structure;anxiety symptoms;Attenuated;cancer diagnosis;Chronic low back pain;chronic pain;chronic pain patient;chronic painful condition;Clinical;Clinical Trials;Cognitive;comorbid depression;comorbidity;coping;Data;depressive symptoms;disability;Dose;Double-Blind Method;Ecological momentary assessment;efficacy trial;Face;follow-up;functional improvement;Future;Guidelines;Hallucinogens;improved;Individual;innovation;insight;Intervention;Laboratories;Lead;Life;Major Depressive Disorder;Malignant Neoplasms;Mediating;Medicine;Mental Depression;Modality;Monitor;negative affect;non-opioid analgesic;Outcome;Pain;pain catastrophizing;pain inhibition;Pain intensity;Pain management;pain outcome;pain symptom;Patients;Placebos;Population;Positioning Attribute;primary outcome;Process;Psilocybin;Randomized, Controlled Trials;Reporting;Research;response;Risk;Ritalin;rumination;Safety;Sampling;Science;secondary analysis;Sensory;Serotonin Receptor 5-HT2A;Stimulus;Supervision;Symptoms;Testing;treatment duration;Treatment Efficacy;treatment guidelines;trial comparing;United States National Institutes of Health;Work

PROJECT_TITLE: Psilocybin and Affective Function in Chronic Lower Back Pain and Depression


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PHR: The Functional Genomics and Proteomics (FG&P) Core supports research that increases our understanding of how biological function (e.g., vision) arises from the information encoded in an organism's genome. The Core provides expertise, personnel, training, and equipment for the design, execution, and analysis of molecular, biochemical, proteomic, and vision function and structure experiments. This support is for AVRC investigators who are NEI R01-funded but who cannot justify such services or equipment independently in a single R01- funded project or who are not experts in FG&P techniques. By removing these "barriers of entry," the FG&P Core helps these investigators increase the impact of their research.

PI_NAMEs: BOATRIGHT, JEFFREY H (contact)

PROJECT_TERMS: Area;Biochemical;Biological Process;Cell Culture Techniques;Cell Separation;Collaborations;Communities;Core Grant;Dedications;design;DNA;Equipment;Equipment Design;Expenditure;experience;experimental study;Faculty;faculty community;functional genomics;Funding;Genome;Goals;Healthcare Systems;Human Resources;Individual;Institution;Laboratories;Leadership;Location;Maintenance;Methodology;Microsurgery;Molecular;Molecular Analysis;Morehouse School of Medicine;Mus;Organism;Phenotype;Proteins;Proteomics;Research;Research Personnel;Research Support;Resources;RNA;Rodent;Services;small molecule;Structure;Techniques;Training;Universities;Vision;Vision research

PROJECT_TITLE: P30-Core Grant for Vision Research Core B


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Pulmonary Hypertension

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative In this proposal, we aim to establish the role of a specific ribonucleic acid molecule called KMT2E-AS1 that we believe promotes the development of a deadly yet enigmatic disease of the blood vessels in the lung, pulmonary hypertension (PH). We also will pursue evidence that specific changes in our DNA control the expression of this molecule and increase the risk of PH for those individuals. If successful, our work will set the stage for a new era for medical care of PH patients, whereby therapies that target this molecular pathway can be deployed to specific individuals with the highest likelihood of a positive response.

PI_NAMEs: CHAN, STEPHEN Y (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: adeno-associated viral vector;Alleles;American;Automobile Driving;Binding;Biology;Blood specimen;cadherin 5;Caring;Cells;ChIP-seq;chromatin remodeling;cohort;CRISPR/Cas technology;Data;Development;Disease;DNA;Endothelial Cells;Endothelium;Ensure;Epigenetic Process;epigenetic therapy;functional genomics;Genes;Genetic;Genetic Carriers;genome editing;Genomics;Genotype;Hematological Disease;histone methylation;Histone-Lysine N-Methyltransferase;Histones;Human;humanized mouse;Hypoxia;in vivo;Individual;induced pluripotent stem cell;inhibitor;insight;Introns;knock-down;Knock-out;Link;Lung;Lung Diseases;lung hypoxia;Lysine;Medical;Meta-Analysis;Metabolic;Metabolic dysfunction;Metabolism;Methylation;Modeling;Molecular;molecular targeted therapies;Mus;nanoparticle;Pathogenicity;Pathway interactions;Patients;Phenocopy;Phenotype;Positioning Attribute;promoter;Proteins;Publishing;Pulmonary Hypertension;pulmonary vascular remodeling;Quantitative Trait Loci;Rattus;Regulation;response;Risk;RNA;Rodent;Role;Severities;Single Nucleotide Polymorphism;Slice;Small Interfering RNA;Specificity;Structure of parenchyma of lung;Transcript;transcription factor;Untranslated RNA;Validation;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: Genetic and hypoxic control of a lncRNA axis orchestrates endothelial reprogramming in pulmonary hypertension


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GEISERT, ELDON E (contact)

PROJECT_TERMS: Basic Science;Bioinformatics;bioinformatics resource;Biological;Biometry;Budgets;Communities;Computer software;computing resources;Consult;Core Grant;Data;data acquisition;Data Analyses;Data Collection;data mining;Data Set;Data Storage and Retrieval;Experimental Designs;experimental study;Funding;Genetic;genomic tools;Goals;Hand;Human Resources;Image Analysis;image processing;improved;Individual;Informatics;informatics training;innovation;Institution;laboratory experience;Laboratory Personnel;large datasets;Mathematics;Methods;power analysis;Proteomics;Protocols documentation;Research;Resources;Schools;Secure;Services;Software Tools;Systems Biology;Talents;Technology;Testing;tool;Training;Translational Research;Universities;Vision research;vision science;Visual System;Work

PROJECT_TITLE: P30-Core Grant for Vision Research Core C


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Sexual minority women (SMW; e.g., lesbian, bisexual) are at disproportionately high risk of hazardous drinking (HD) and associated negative health outcomes compared to heterosexual women, likely due to their higher lifetime exposure to multiple and chronic stressors. Although there is a great deal of literature demonstrating that close, intimate relationships buffer stress among women in the general population, very little research has investigated HD within SMW's intimate relationships. This study aims to understand HD within same-sex female couples by considering both individual- and couple-level perspectives with the goal of informing the development of interventions to help couples implement healthy coping strategies.

PI_NAMEs: VELDHUIS, CINDY B (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Acceleration;Address;Affect;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;analytical method;Area;Award;Bisexual;Buffers;career;career development;Characteristics;Chronic;Coping Behavior;Coping Skills;Couples;Data;Development;Discrimination;drinking;drinking behavior;emotion regulation;Event;Exclusion;experience;Exposure to;Faculty;Female;female couples;Frequencies;Funding;General Population;Geography;Goals;hazardous drinking;Health;Health behavior;Health Benefit;health disparities in women;health disparity;Heterosexuals;high risk;Individual;innovation;Institution;Interview;Laboratories;Lead;Lesbian;Link;Literature;Marriage;Measures;member;Mentors;Mentorship;Methodology;Methods;Minority;minority stress;minority stressor;Monitor;Motivation;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;New York City;novel;Outcome;Pathway interactions;Phase;Political Factor;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;professor;programs;psychologic;Psychologist;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Resources;response;Risk;Role;Same-sex;same-sex partnership;Sampling;satisfaction;Scientist;Secure;Sex Orientation;sexual minority health;sexual minority women;social stigma;Source;Stress;stress management;stressor;substance use;Surveys;symposium;tenure track;Testing;Theoretical model;theories;therapy development;timeline;Training;Training Activity;United States National Institutes of Health;Universities;Woman;Women's Health

PROJECT_TITLE: A mixed-methods approach to understanding stress and hazardous drinking among same-sex female couples