NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Agreement;Alzheimer's Disease;Atlases;Award;Bioinformatics;Biology;Brain;Businesses;ChIP-seq;Collaborations;college;Communication;Communities;conflict resolution;Consult;Consultations;Data;Data Analyses;data integration;Data Set;data sharing;Ensure;Evaluation;Funding;Human Resources;Individual;Infrastructure;Institution;Leadership;lectures;Licensing;Lysosomes;medical schools;Medicine;meetings;member;metabolome;metabolomics;mid-career faculty;Molecular and Cellular Biology;Multiomic Data;multiple omics;Notification;Occupational activity of managing finances;Online Systems;Output;Process;Program Research Project Grants;programs;Proteome;Proteomics;Reagent;recruit;Regulation;Reporting;Research;Research Personnel;Resources;Sampling;Scientist;Signal Transduction;Site;success;symposium;synergism;Tauopathies;transcriptome sequencing;United States National Institutes of Health;Universities;Visualization;Washington;Work

PROJECT_TITLE: Administration and Data Integration Core


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE As youth, especially those orphaned by HIV/AIDS, transition into young adulthood, they are faced with limited social support and opportunities for education and employment, which elevates their vulnerability to poverty, poor mental health functioning and other negative life outcomes, including risk-taking behaviors exposing them to HIV/AIDS and poor health outcomes. The proposed Bridges-Round 2 study will extend the recently completed efficacious Bridges to the Future study to examine the longitudinal impact of a family-based economic empowerment intervention on the developmental and behavioral health outcomes, and transition milestones for young people orphaned by AIDS in Uganda. Findings from this large longitudinal dataset may contribute to the scientific knowledge on the potential value of investing modest economic resources in poor and vulnerable boys and girls during early adolescence and how these resources may offer long-term protection against known HIV and mental health risks—two public health issues impacting millions of young people in low-resource communities.

PI_NAMEs: NABUNYA, PROSCOVIA ;SENSOY BAHAR, OZGE ;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 14 year old;16 year old;Acquired Immunodeficiency Syndrome;Adolescent;Adolescent and Young Adult;adverse childhood events;Affect;Africa South of the Sahara;Age;age group;AIDS prevention;alcohol misuse;Alcohols;antiretroviral therapy;Behavior;behavioral health;behavioral outcome;Biological Markers;boys;Caring;Childhood;cohort;Continuity of Patient Care;cost;Cost-Benefit Analysis;Costs and Benefits;Data;Development;drug misuse;early adolescence;economic evaluation;Economics;Education;Effectiveness;Employment;empowerment;Enrollment;experience;experimental study;Family;Future;girls;Goals;Guide prevention;Health;Health behavior;HIV;HIV anti-retroviral;HIV Infections;HIV risk;HIV Seronegativity;HIV-infected adolescents;HIV/AIDS;Home;Human immunodeficiency virus test;improved;Incidence;innovation;Intervention;Investments;Knowledge;Life;Life Cycle Stages;Long-Term Effects;longitudinal dataset;Male Circumcision;Marriage;Measures;Medical;Mental Health;migration;Outcome;Parents;Participant;Patient Self-Report;Perception;Performance;Personal Satisfaction;Persons;Policies;poor health outcome;Population;Poverty;pre-exposure prophylaxis;premature;Prevalence;Prevention;primary outcome;Primary Schools;Program Sustainability;programs;Public Health;reproductive;Research;Resource-limited setting;Resources;response;retention rate;Risk;Risk Behaviors;Risk Taking;Rural;scale up;Schools;secondary analysis;Sex Behavior;Sexual Health;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Social Controls;social disparities;social stigma;Social support;success;Testing;therapy adherence;Translating;treatment adherence;Uganda;United States National Institutes of Health;Viral;Viral Load result;Well in self;Work;young adult;Youth

PROJECT_TITLE: Bridges-Round 2: Evaluating the Long-term Impact of a Family Economic Empowerment Intervention on HIV Risk Prevention and Care Continuum Outcomes among Orphaned Youth Transitioning to Young Adulthood

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE It has been suggested that many retinal diseases are mediated by abnormalities in retinal synaptic circuits, such as rod and cone dystrophy in retinitis pigmentosa, macular degeneration, congenital stationary night blindness (CSNB) and glaucoma. Our multi-cellular analysis of retinal circuits will provide important new insights into how synaptic abnormalities contribute to various retinal disorders.

PI_NAMEs: JIANG, XIAOLONG ;WU, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adopted;Adoption;Affect;Behavior;cell type;Cells;Characteristics;Classification;Classification Scheme;Cone;connectome;Coupled;Coupling;Darkness;Disease;Distant;electrical property;Electrodes;Equation;Exhibits;Feedback;functional group;ganglion cell;Glaucoma;Goals;horizontal cell;Human;Individual;Injections;insight;Kinetics;Knowledge;Lateral;Learning;Light;Light Adaptations;Light Cell;light effects;Location;Macular degeneration;Maps;Mediating;Monitor;Nervous System;network dysfunction;neural circuit;neural network;neuronal circuitry;Neurons;Night Blindness;operation;Pathway interactions;Photoreceptors;Physiological;postsynaptic;presynaptic;Property;Radial;Reaction Time;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal neuron;retinal rods;Retinitis Pigmentosa;Rod;Role;Salamander;Shapes;signal processing;Signal Transduction;spatiotemporal;Stimulus;Synapses;System;Taxonomy;Techniques;two-dimensional;Variant;Vertebrate Photoreceptors;visual information;visual processing;voltage clamp;voltage gated channel

PROJECT_TITLE: Multi-Cellular Analysis of the Retinal Network

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The immune system is able to recognize and eliminate pathogen infected cells and newly arising tumors. However, certain pathogenic infections are not efficiently cleared and lead to chronic infections that often lead to dysfunctional pathogen-specific CD8 T cells. The identification and characterization of why certain viral and bacterial infections are not cleared and how they promote T cell dysfunction is a major goal of this application.

PI_NAMEs: TORRES, RAUL MARTIN (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immune response;adaptive immunity;antagonist;Antibody Response;antigen-specific T cells;Antigens;ARHGEF1 gene;Bacterial Infections;Biochemical;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Chronic;chronic infection;cytokine;Cytoplasmic Granules;Cytoskeletal Modeling;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;design;effector T cell;Enzymes;Event;experimental study;extracellular;Functional disorder;G-Protein-Coupled Receptors;Genetic Transcription;global health;Goals;Human;Humoral Immunities;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunotherapy;Impairment;improved;in vivo;Individual;Infection;Inflammatory;Lipids;Lymphocytic choriomeningitis virus;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Lysophospholipids;Lytic;Major Histocompatibility Complex;Malignant Neoplasms;Memory;Molecular;Mus;novel;pathogen;pathogen exposure;Pathogenicity;Peptide/MHC Complex;Peptides;Physiological;Play;pre-clinical;Production;programs;Proliferating;receptor;Receptor Signaling;Regulation;response;Reticular Cell;Role;secondary lymphoid organ;Signal Induction;Signal Pathway;Signal Transduction;Site;small molecule;small molecule inhibitor;success;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Therapeutic Intervention;trafficking;translational study;tumor;Vaccines;Viral;Virus;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Lysophosphatidic Acid Regulation of CD8 T cell activation and function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative With the increase in auto-immune diseases and emerging concerns of compromised immunity in our aging culture and vulnerable children, understanding T cell signaling, metabolic processes, and the resources required for proper immune response and functioning is extremely relevant to public health. This project explores how metabolism is controlled in T cell immune responses at the level of precise biochemical reaction and molecular interactions, which are amenable to pharmacologic and dietary manipulation. This proposal will enable developing novel therapeutic interventions by targeting the metabolic pathways for T cell-mediated inflammatory and autoimmune diseases, which aligns with the NIAID’s and NIGMS’s mission to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.

PI_NAMEs: WANG, RUONING  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acceleration;Acids;Age;Aging;Allergic Disease;Amino Acids;Anabolism;Animal Model;Anti-Inflammatory Agents;Antigens;Applied Research;Arginine;Arthritis;Autoimmune Diseases;Autoimmunity;Basic Science;Binding;Biochemical Reaction;Bioenergetics;Biological Availability;Biological Models;Biomass;c-myc Genes;Carbon;Catabolism;CD4 Positive T Lymphocytes;Cell Differentiation process;cell mediated immune response;Cell Proliferation;Cells;Cellular Metabolic Process;Child;Clinical;Collagen;Communicable Diseases;cost;cytokine;Dependence;dietary;dietary approach;dietary manipulation;dietary restriction;Disease;Effector Cell;effector T cell;Environment;Eragrostis;Experimental Autoimmune Encephalomyelitis;Genes;Genetic;genetic approach;Growth;Homeostasis;immune function;Immune response;Immune signaling;Immune System Diseases;Immunity;Immunologic Surveillance;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Location;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mission;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;National Institute of Allergy and Infectious Disease;National Institute of General Medical Sciences;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;Organism;Ornithine;Outcome;Ovalbumin;Pathogenesis;Pathway interactions;pharmacologic;Physiological Processes;Polyamines;prevent;Process;Production;programs;Proliferating;Protein Biosynthesis;Public Health;Receptor Activation;reconstitution;Resources;response;Rheumatoid Arthritis;Signal Transduction;Specificity;T cell differentiation;T cell response;T-Cell Activation;T-cell inflamed;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapy outcome;Tissues;transcription factor;transcriptomics;uptake

PROJECT_TITLE: Dissect and target Arginine-polyamine metabolic axis in T cell mediated inflammation and autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: YOUNG, NICOLAS L (contact)

PROJECT_TERMS: Acetyl Coenzyme A;age-related disease;Aging;aging related;Alzheimer's Disease;Atlases;Biochemical;Biogenesis;Biology;Biology of Aging;Cell Nucleus;Cells;Chromatin;Collaborations;Communities;Complement;Computer Analysis;cost effective;Data;Data Analyses;Development;Digestion;Epigenetic Process;Epitopes;Event;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;Hippocampus;histone modification;Histones;Homeostasis;innovation;insight;Label;lysosomal proteins;Lysosomes;Measures;Mediating;Metabolic;metabolome;metabolomics;Methods;Molecular;Multiomic Data;Mus;Mutation;Nuclear;Organelles;Peptides;Post Translational Modification Analysis;Post-Translational Protein Processing;Program Research Project Grants;programs;protein expression;Protein Isoforms;Proteins;Proteolysis;Proteolytic Processing;Proteome;Proteomics;proteostasis;Regulation;Reproducibility;Research;Research Project Grants;Sampling;Signal Transduction;single molecule;Specificity;Statistical Data Interpretation;synergism;System;Tauopathies;tool;Transcriptional Regulation;Trypsin;Validation;Variant;Work;Writing

PROJECT_TITLE: Proteomics and Post-translational Modification


ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: NARRATIVE  Immunotherapies can augment T cells for potent responses against some cancers, yet are ineffective against others. We propose several experiments to identify the molecular details of transcriptional programs that limit, and those that could enhance, T cells responses in tumors. These analyses will deﬁne transcriptional control of anti-tumor immune responses and identify potential targets to improve immunotherapies against diverse cancers.

PI_NAMEs: SCOTT-BROWNE, JAMES  (contact)

PROJECT_TERMS: acute infection;Adoptive Cell Transfers;Adoptive Transfer;Animals;anti-tumor immune response;Antibodies;Antigens;Binding;bZIP Domain;Cancer Patient;cancer therapy;candidate identification;Cell Physiology;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chromatin;Chronic;Chronic Disease;chronic infection;cofactor;cytokine;cytotoxic;Effector Cell;engineered T cells;exhaust;exhaustion;experimental study;Failure;Family member;Foundations;functional improvement;Gene Expression;Genes;Genetic;Genetic Transcription;Human;immune checkpoint blockade;Immunotherapy;improved;Individual;Infection;Leucine Zippers;Link;Malignant Neoplasms;Modeling;Molecular;morphogens;Mus;neoplastic cell;novel;novel strategies;NR4A1 gene;NR4A2 gene;Nuclear Receptors;Outcome;Patients;Phenotype;Population;Production;programs;Publishing;receptor;receptor expression;Regulatory Element;Resistance;response;small molecule;Solid Neoplasm;T cell differentiation;T cell response;T cell therapy;T cell transcription factor 1;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic Effect;Therapeutic Intervention;transcription factor;Transcriptional Regulation;Translating;tumor;tumor growth;Virus Diseases;Work

PROJECT_TITLE: Transcriptional Control of T Cell Function

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The proposed project will determine the mechanisms that control pancreatic -cell endoplasmic reticulum (ER) Ca2+ (Ca2+ER) handling and their importance regulating islet hormone secretion. Results from this project are expected to provide significant insights into how glucose-stimulated-cell Ca2+ER handling becomes disrupted in T2D and perturbs islet hormone secretion. Thus, the proposed research project will generate fundamental knowledge about human islet -cells that will help reduce the burden of human illness in the context of diabetes.

PI_NAMEs: JACOBSON, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Amino Acids;Animal Disease Models;blood glucose regulation;Calcium-Sensing Receptors;Cell Physiology;Cells;Coupled;Cytoplasm;D Cells;Data;Diabetes Mellitus;diabetes pathogenesis;diabetic;Disease;Dominant-Negative Mutation;driving force;Endoplasmic Reticulum;experimental study;Functional disorder;G alpha q Protein;G-Protein-Coupled Receptors;gain of function mutation;Glucagon;Glucose;Goals;Homeostasis;Hormone secretion;Human;insight;Insulin;insulin secretion;islet;Islets of Langerhans;knock-down;Knowledge;Laboratory Finding;maturity onset diabetes of the young;Mediating;Medical;Membrane Potentials;Molecular;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Pancreas;Pancreatic delta Cell;Pathogenesis;Pathway interactions;Patients;pharmacologic;Physiological;Population;Potassium Channel;receptor;Receptor Signaling;Research;Research Project Grants;response;Role;Signal Transduction;small hairpin RNA;Somatostatin;Stress;Testing;Transgenic Mice

PROJECT_TITLE: Molecular Mechanisms Regulating Pancreatic Delta Cell Function and Dysfunction

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pediatric;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative The root cause of systemic failure to identify and treat childhood TB worldwide is the challenge of accurate diagnosis. Two novel biomarker approaches, based on host blood RNA signatures and a simplified T cell Antigen-Specific Activation assay that target complementary aspects of the host immune response, have been discovered and validated in adults and offer promise as biomarkers of childhood TB. We will evaluate diagnostic and prognostic performance of these biomarkers for pediatric TB disease, to inform feasibility and potential impact of biomarker-targeted TB screening strategies for children.

PI_NAMEs: HATHERILL, MARK  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: accurate diagnosis;Adolescent;Adult;Algorithms;antigen-specific T cells;authority;Bacille Calmette-Guerin vaccination;Biological Assay;Biological Markers;biomarker performance;Blood;Blood specimen;candidate marker;CD4 Lymphocyte Count;Characteristics;Child;Childhood;cohort;Communities;cost;cost effective;cost effectiveness;Country;curative treatments;Data;Decision Making;Detection;Diagnosis;Diagnostic;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;Disease;Disease Progression;Enrollment;epidemiological model;Evaluation;experience;Exposure to;Failure;Gene Expression Profile;Genes;Genetic;Genetic Determinism;genetic signature;Genetic Transcription;genetic variant;Geography;Health;HIV;HIV/TB;Household;Immune;Immune response;Immune system;improved;Incidence;Individual;industry partner;Inflammatory;Interferon Type II;Interferons;Investigation;Laboratories;Measures;Micro Array Data;Modeling;Monitor;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;novel diagnostics;novel marker;novel strategies;Pathogenesis;Patients;Performance;performance tests;point of care;Population;Preventive therapy;Prognosis;prognostic;prognostic assays;prognostic performance;progression risk;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;Research Personnel;respiratory;response;response biomarker;Risk;RNA;sample collection;Sampling;screening;screening program;South African;Specificity;Standardization;T-Cell Activation;T-Lymphocyte;targeted biomarker;Testing;tool;Translating;treatment response;Tuberculosis;Tuberculosis diagnosis;Tuberculosis Vaccines;Validation;Variant;Whole Blood

PROJECT_TITLE: Host blood biomarkers for the diagnosis prognosis and treatment response of childhood TB

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: LI, FENG  (contact)

PROJECT_TERMS: Affect;Age;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;amino acid metabolism;Amino Acids;Astrocytes;Atlases;Biology;Biology of Aging;cell growth;Cells;Collaborations;Coupled;data acquisition;Data Analyses;Disease Progression;Environment;Enzymes;fluorescence lifetime imaging;Foundations;Functional disorder;Genetic;genetic manipulation;Genetic Transcription;Genotype;Goals;healthy aging;High Pressure Liquid Chromatography;Hippocampus;Homeostasis;imaging platform;in vivo monitoring;innovation;Knowledge;Lasers;Libraries;Link;Longevity;lysosomal proteins;Lysosomes;macromolecule;mass spectrometer;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;metabolome;metabolomics;Methods;Modification;mouse model;Multiomic Data;Mus;nanoscope;Neurodegenerative Disorders;Neuroglia;Neurons;new technology;Nuclear;Organelles;Organism;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phagocytes;Photons;Physiological;Play;Proteome;Protocols documentation;Quality Control;Regulation;Research;Research Project Grants;Resolution;Resources;Role;Sampling;Scanning;Series;Signal Transduction;synergism;System;tau Proteins;Tauopathies;Techniques;Technology;technology platform;Time;trafficking;two-photon;Wild Type Mouse

PROJECT_TITLE: Lysosomal Metabolomics and pH


NIH_SPENDING_CATS: Aging

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

ORG_STATE: MA

PHR: OTHER PROJECT INFORMATION – Project Narrative Invalid drug patents, particularly invalid patents on secondary drug features (e.g., routes of administration) have the potential to prolong effective patent lives and delay widespread patient access to longevity-improving drugs. This project will explore the effects of increasing the resources to U.S. patent examiners—mainly, the time allocated to patent examiners—on the rate of issuance of invalid drug patents, while also exploring the efficiency of screening valid from invalid drug patents at the administrative-agency level relative to doing so via the courts. In the process, this project will construct novel databases on both small- and large-molecule drug patents that will prove valuable both to our investigation into strengthening ex ante review of drug patents and to the broader community researching drug patents.

PI_NAMEs: FRAKES, MICHAEL D. (contact);WASSERMAN, MELISSA

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TITLE: The Impacts of Enhanced Drug-Patent Examination

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: SARDIELLO, MARCO  (contact)

PROJECT_TERMS: Affect;Age;Age Factors;age related;age related changes;age related neurodegeneration;Aging;aging brain;aging related;Alzheimer's Disease;Atlases;Attenuated;Autophagocytosis;Brain;brain tissue;Cardiovascular Diseases;Cell Nucleus;Cells;cellular targeting;Chromatin;Chromatin Remodeling Factor;Clinical Treatment;conditional knockout;constitutive expression;Data;Degradation Pathway;Dependence;design and construction;Deterioration;Development;Elderly;Enzymes;exhaust;extend lifespan;Foundations;frailty;Future;Genes;Genetic Transcription;genome-wide;Goals;hallmarks of aging;Health;Healthcare;healthspan;Histones;Homeostasis;Individual;Investigation;Knock-in;knowledge of results;life span;Link;Longevity;Lysosomes;macromolecule;male;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolism;metabolome;Modernization;Molecular Target;Morbidity - disease rate;Mus;Nerve Degeneration;Neurons;Organ;Organelles;Organism;pathological aging;Pathway interactions;Pattern;Phenotype;Population;Post-Translational Protein Processing;Predisposition;programs;protein aggregation;Proteome;Proteomics;Regulation;senescence;sex;Signal Pathway;Signal Transduction;SIRT1 gene;synergism;Tauopathies;Testing;therapy development;Tissues;tool;transcription factor;Transducers;Translational Research;Work

PROJECT_TITLE: TFEB-mediated lysosome-to-nucleus signaling in aging and lifespan regulation


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative We seek to clarify the interactive effects of COVID-19 biopsychosocial stressors, alcohol use and neurobiobehavioral decline in drinkers aged 65-75 of both majority and minority race/ethnicity. Towards this end, applying a multi-method/multi-modal approach, we will ascertain alcohol use patterns, psychological stressors, neurophysiology and cognitive function across a 3 year period. This work will yield novel findings regarding the impact of the prolonged COVID-19 pandemic on stress measures, alcohol use and neurobiobehavioral stability across a critical period of transition.

PI_NAMEs: NIXON, SARA JO (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Accounting;Acute;Address;Age;aged;Aging;aging process;Alcohol consumption;Alcoholic beverage heavy drinker;Alcohols;biopsychosocial;Black race;Chronic;chronic pain;cognitive function;Contracts;COVID-19;COVID-19 impact;COVID-19 pandemic;critical period;Data;design;Distress;drinking;Emotional;Ethnic Origin;experience;Female;Health;Health Planning;Heavy Drinking;Impaired cognition;Indigenous;infection rate;Light;Link;Literature;Loneliness;long term consequences of COVID-19;Longitudinal Studies;longitudinal, prospective study;male;marijuana use;Masks;Measures;Mediation;Mediator;men;Methods;Modeling;multimodality;negative affect;neurophysiology;novel;older adult;optimism;Outcome;Pain;pandemic disease;pandemic potential;Pathway interactions;Patient Self-Report;Pattern;people of color;Performance;Phase;Prevention;prospective;Prospective Studies;psychological distress;psychological stressor;Public Health;Race;racial difference;racial minority;Reporting;Research;response;Risk;Risk Factors;Role;Severities;sex;Sex Differences;Sleep disturbances;sleep quality;social;Social Distance;social engagement;Social isolation;Stress;stressor;Time;transmission process;Vaccinated;vaccine hesitancy;Variant;Woman;Work

PROJECT_TITLE: Determining the Longer-term Impact of COVID-19 Stressors, Alcohol Use and Neurobiobehavioral Decline in Older Adults Through Prospective Study


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE  Patients who develop delirium during hospitalization in the intensive care unit (ICU) are at higher risk of developing dementia. This project will establish a foundation for studying the physiologic changes in the brain that indicate ICU delirium and predict long-term cognitive impairment.

PI_NAMEs: WILLIAMS ROBERSON, SHAWNIQUA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Academic Medical Centers;Admission activity;Age;Age Years;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Anesthesia procedures;Anesthetics;Area;Arousal;Award;Biomedical Engineering;Brain;Brain Diseases;brain dysfunction;career;career development;Clinical;Clinical assessments;clinical diagnosis;Clinical Research;Cognitive;cognitive function;cognitive neuroscience;cognitive performance;cognitive testing;cohort;Communication;Critical Care;Critical Illness;Data;Dedications;Delirium;Dementia;design;Development;Development Plans;Dexmedetomidine;Disease;Electroencephalography;Electrophysiology (science);Engineering;Ensure;Evolution;experience;Fellowship;follow-up;Foundations;Frequencies;Funding;Goals;Grant;high risk;Hospitalization;Hospitals;human old age (65+);Impaired cognition;inattention;indexing;Inpatients;insight;Intensive Care Units;Intervention;Leadership;Literature;Measurable;Measurement;Measures;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;mild cognitive impairment;Monitor;Neurobiology;Neurocognitive;Neurologist;Neurology;neurophysiology;Neuropsychology;neurotransmission;novel;older adult;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Outcomes Research;Patient Admission;Patient Monitoring;patient oriented;Patients;Pattern;Performance;Physicians;Physiological;Physiology;Population;postoperative delirium;predictive modeling;professor;Propofol;Quality of life;Recovery;Research;Research Methodology;Research Personnel;research study;Rest;Science;Scientist;sedative;Severity of illness;signal processing;skills;Survivors;survivorship;Techniques;Time;tool;Training;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: EEG Signatures of ICU Delirium and Post-ICU ADRD

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This study has the potential to positively impact public health by improving the implementation and equity impact of Universal School Meals (USM) by developing and pilot testing an equity- focused implementation strategy with the School District of Philadelphia (SDP), examining impact on equity of implementation and obesity prevention. This research project provides an innovate intersection of implementation science and health equity, addressing objective 6 of NHLBI to optimize clinical and implementation research to improve health and reduce disease.

PI_NAMEs: MCLOUGHLIN, GABRIELLA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Academic achievement;Address;Adolescent;Adopted;Adoption;Adult;Behavior;cardiovascular disorder prevention;cardiovascular disorder risk;career;career development;Child;Child Nutrition;Childhood;Clinical Research;Clinical Trials;Collaborations;Communities;community engaged approach;community partners;Complex;Consolidated Framework for Implementation Research;Consumption;cost;Cost Analysis;Data;design;Development;Development Plans;Diet;dietary;Disease;Disparity;Doctor of Philosophy;Eating;Effectiveness;effectiveness/implementation trial;Energy Intake;Enrollment;Ensure;environmental intervention;Equity;ethnic minority;experience;Focus Groups;food environment;food insecurity;Food Services;Foundations;Goals;Group Interviews;Growth and Development function;Health;health determinants;health equity;health inequalities;high school;implementation barriers;implementation determinants;implementation efforts;implementation evaluation;implementation outcomes;implementation protocol;implementation research;implementation science;implementation strategy;improved;Inequity;innovation;Intervention;Interview;junior high school;K-12 Education;K-Series Research Career Programs;Link;Low income;Low Income Population;Maps;marginalization;Measures;Mentored Research Scientist Development Award;Mentorship;Methods;minority children;Modeling;National Heart, Lung, and Blood Institute;Needs Assessment;neglect;Nutrient;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;Parents;Penetration;Performance;Philadelphia;pilot test;pilot trial;Policies;pragmatic randomized trial;Predisposition;Prevention;Price;Procedures;programs;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Risk;Sampling;school district;Schools;social health determinants;student participation;Students;Surveys;System;Target Populations;teacher;Testing;Time;Training;Universities;Vulnerable Populations;Weight;Work;Youth

PROJECT_TITLE: Using implementation mapping to maximize equity of school-based policies for obesity prevention

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: ZHENG, HUI  (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;age related;Aging;Alzheimer's Disease;Alzheimer's disease brain;Astrocytes;Atlases;Autophagocytosis;Behavioral;Binding;Brain;brain health;Cell Nucleus;combat;Communities;comparative;Cytoplasm;Data;data integration;Dependence;Disease;Exhibits;Frontotemporal Dementia;functional decline;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hippocampus;Homeostasis;Human;hyperphosphorylated tau;Immune;Immune response;Immunoprecipitation;immunoregulation;Impairment;In Vitro;in vivo;insight;Knock-in Mouse;Knockout Mice;Link;lysosomal proteins;Lysosomes;Mediating;metabolome;metabolomics;Microglia;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;novel;Nuclear;Nuclear Translocation;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiological;Post-Translational Protein Processing;Program Research Project Grants;programs;promoter;Property;Proteome;Proteomics;Proxy;Regulation;Regulatory Pathway;Research;Research Personnel;response;Role;Signal Pathway;Signal Transduction;Sorting;Stress;synergism;System;tau aggregation;tau Proteins;Tauopathies;Technology;Testing;therapeutic target;transcription factor;transcriptome sequencing;transcriptomics;Transgenic Mice;Up-Regulation;vacuolar H+-ATPase;Wild Type Mouse

PROJECT_TITLE: A TFEB and V-ATPase-mediated lysosomal stress sensing pathway in tauopathy


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Disability Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Precision Medicine;Prevention;Primary Health Care;Rehabilitation;Telehealth

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This application seeks to answer the fundamental questions of which initial, first-line weight loss intervention should be offered to older adults with obesity and multiple chronic conditions and how to address the high non- response rates observed with most conventional strategies. A sequential, multiple assignment, randomized trial design will permit the evaluation of treatment combinations that maximize weight loss and will provide data on constructing a future tailored, adaptive intervention. If successful, these findings will identify interventions that could markedly improve health and quality of life of these older adults, reduce long-term disability, and lower healthcare costs.

PI_NAMEs: BATSIS, JOHN A. (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: adaptive intervention;Address;adult obesity;adverse outcome;Anthropometry;arm;Arthritis;Behavior Therapy;Behavioral;Body Weight Changes;Body Weight decreased;Cessation of life;Characteristics;Chronic;Clinical;clinical decision-making;clinical heterogeneity;Clinical Trials;clinically significant;Collaborations;Combined Modality Therapy;comparative effectiveness trial;Complex;Cost Analysis;cost effective intervention;cost effectiveness;Data;Diabetes Mellitus;diet and exercise;Dietitian;disability;disability risk;efficacy evaluation;Enrollment;Evaluation;Evidence based intervention;exercise prescription;functional decline;Future;Geriatrics;global health;Goals;Health;Health behavior change;Health Care Costs;Health Promotion;health training;high risk;high risk population;human old age (65+);Hypertension;improved;incremental cost;indexing;Individual;individualized medicine;innovation;Institute of Medicine (U.S.);Intervention;Licensing;Life Style;Long term disability;Medical;Medicare;Modeling;mortality;Motivation;multiple chronic conditions;muscle form;National Institute on Aging;Nursing Homes;Nutritional Study;Obesity;older adult;Outcome;Participant;Patients;Pattern;personalized approach;personalized care;Persons;Physical Function;physical therapist;Pilot Projects;pilot test;Policies;Positioning Attribute;post intervention;Precision Health;precision medicine;Prevalence;primary care provider;primary outcome;Problem Solving;Quality of life;Quality-Adjusted Life Years;Randomized;randomized trial;remote monitoring;Research;Research Priority;response;Risk;Risk Factors;Science;secondary outcome;Sequential Multiple Assignment Randomized Trial;skills;Strategic Planning;success;telehealth;Telemedicine;Testing;Time;Training;treatment response;treatment strategy;trial design;United States National Institutes of Health;Weight;Weight Gain;weight loss intervention;Work

PROJECT_TITLE: Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults with Multiple Chronic Conditions: A Sequential, Multiple Assignment, Randomized Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunotherapy;Lymphatic Research;Nanotechnology;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Organ transplantation has become a life-saving strategy for patients with irreversible organ diseases. However, ischemia reperfusion injury (IRI) of the transplanted organ occurs inevitably following the operation and augments inflammatory responses within the organ markedly, leading to transplant rejection. This project seeks to unveil the mechanisms by which IRI induces this immune response and harness this knowledge to develop novel therapies that will improve transplant outcomes.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Address;Alloantigen;allograft rejection;Allografting;Anatomy;Autophagocytosis;Binding;Blood Vessels;Calcineurin inhibitor;chemokine;Chronic;Clinical;clinical efficacy;comorbidity;conditional knockout;Data;Dendritic Cells;Disease;Dose;draining lymph node;effector T cell;Equilibrium;experimental study;Extracellular Matrix;Goals;Graft Rejection;Heart;Heart Transplantation;High Endothelial Venule;Homing;Hour;IL6 gene;Immune;immune activation;immune modulating agents;Immune response;Immunity;immunogenicity;immunoregulation;Immunotherapeutic agent;improved;Inflammatory;inflammatory milieu;Inflammatory Response;Injections;Injury;Innate Immune Response;Interleukin-6;Ischemia;ischemic injury;isoimmunity;ITGAX gene;Knowledge;Life;lymph nodes;lymphatic vessel;Lymphoid Tissue;Mediating;Metabolic;Methods;Microanatomy;Monoclonal Antibodies;Mus;nanocarrier;Nanodelivery;nanoparticle;Natural Immunity;novel;novel therapeutics;operation;optimal treatments;Organ;Organ Donor;Organ Transplantation;Outcome;Patients;Phase;Play;post-transplant;Predisposition;prevent;Production;Regimen;Regulatory T-Lymphocyte;Reperfusion Injury;response;Reticular Cell;Role;Safety;Site;Stromal Cells;surface coating;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Time;time use;trafficking;Transgenic Mice;transplant model;Transplant Recipients;Transplantation

PROJECT_TITLE: IRI, innate immunity and transplant rejection

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: We are attempting to develop an easy and cost effective method for equipping a patient’s immune cells with a molecular GPS system that will guide them to tumors so that they can be eliminated.

PI_NAMEs: WAGNER, CARSTON R. (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Affinity;Antibiotics;Antibodies;Antigen Targeting;Antigens;arm;Avidity;B lymphoid malignancy;bi-specific T cell engager;Binding;Bispecific Antibodies;Bite;Breast Cancer Cell;cancer cell;cancer immunotherapy;Cancer Model;Cancer Patient;cancer stem cell;cancer therapy;CD3 Antigens;Cell Adhesion Molecules;Cell membrane;Cell surface;Cells;chemical addition;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;clinical development;clinically relevant;combat;Consumption;Continuous Infusion;cost effective;crosslink;cytokine;cytotoxicity;Development;Dihydrofolate Reductase;Dose;Engineering;Epithelial Cells;FDA approved;fluorophore;genetic approach;Genetic Engineering;Heterogeneity;Immune;Immunotherapy;In Vitro;in vivo;Incubated;Inflammatory;Libraries;Ligands;Malignant Neoplasms;method development;Methodology;Methods;Methotrexate;Molecular;Mus;Natural Killer Cells;neoplastic cell;non-genetic;Normal tissue morphology;Oligonucleotides;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;Primary Neoplasm;Progression-Free Survivals;Proliferating;Prosthesis;radiotracer;Resistance;Resistance development;Safety;self assembly;Solid Neoplasm;Specificity;success;Surface Antigens;System;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;Toxic effect;Trimethoprim;triple-negative invasive breast carcinoma;trispecific killer engager;tumor;tumor eradication;tumor initiation;Tumor Markers

PROJECT_TITLE: Targeting Effector Immune cells to Cancer with Chemically Self-Assembled Nanorings (CSANs)


PI_NAMEs: JANKOWSKY, JOANNA L (contact)

PROJECT_TERMS: Adult;Affect;Age;Aging;aging brain;aging related;Alleles;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Attention;Biology;Brain;brain cell;brain tissue;Catabolism;cell type;Cells;Cellular Stress;Characteristics;Code;Cognitive;Communities;Consensus Sequence;Data Set;Dementia;Disease;disorder risk;Enzymes;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Gene Expression Profile;Genetic Complementation Test;genetic risk factor;Genetic Transcription;glycosylation;Half-Life;Haplotypes;Health;hippocampal sclerosis;Homeostasis;Human;human old age (65+);human subject;Immunoprecipitation;Impaired cognition;In Vitro;in vivo;insight;Integral Membrane Protein;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;late endosome;Lead;lens;Link;Linkage Disequilibrium;Literature;loss of function;lysosomal proteins;Lysosomes;Maps;Measures;Mediating;metabolomics;Modification;Molecular;Motility;Mus;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;Neurons;neuropathology;Nuclear;overexpression;Parkinson Disease;Pathogenesis;Pathology;Phenocopy;Post-Translational Protein Processing;preservation;programs;Property;protein degradation;Protein Isoforms;Proteins;Proteomics;Regulation;resilience;Risk;Role;Series;Signal Transduction;single nucleus RNA-sequencing;Site;Stress;synergism;tau Proteins;Tauopathies;Technology;Testing;tool;transcriptome sequencing;Transfection;Uncertainty;vacuolar H+-ATPase;Variant;Vesicle;Work

PROJECT_TITLE: TMEM106b as a lysosomal adaptor to influence brain aging and tau pathogenesis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Stategies to amplify the immune response to vaccination, especially protective antibody responses, are of great relevance for the generation of future effective vaccines. In this project, we propose to study mechanisms underlying a particularly effective immunization regimen discovered in small animal model, and develop vaccination approaches that allow this promising approach to be translated to human vaccines.

PI_NAMEs: IRVINE, DARRELL J (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Address;Adjuvant;Animal Model;Antibodies;Antibody Affinity;Antibody Formation;Antibody Response;Antigens;Automobile Driving;B-Lymphocytes;Beds;Binding;Bolus Infusion;cell type;Cells;chemokine;clinically relevant;Clonality;Clone Cells;Collagen;Complement;Computer Analysis;Computer Models;cytokine;design;Disease;Dose;draining lymph node;Drug Kinetics;Effectiveness;Feedback;Future Generations;Generations;Goals;HIV;Human;Humoral Immunities;Immune response;Immunity;Immunization;Immunoglobulin Somatic Hypermutation;Immunologics;in vivo;Inflammation;Injections;Kinetics;Licensing;Lymphocyte Activation;Mediating;Memory B-Lymphocyte;Messenger RNA;Modeling;neutralizing antibody;novel vaccines;Output;pathogen;Pattern;Periodicity;Phenotype;Plasma Cells;Proliferating;Reaction;Regimen;Replicon;response;RNA;RNA vaccine;Role;Specificity;Structure of germinal center of lymph node;Subunit Vaccines;Testing;Translating;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine immunogenicity;vaccine trial;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Healthy speech perception can be limited through a variety of causes, including brain tumor, stroke, cochlear implant usage, and age-related hearing loss. The brain's major mechanism for compensating for degraded speech processes is to integrate auditory-visual speech signals (e.g., lipreading), which restores some hearing abilities. We propose to study the functional mechanisms that support this process and enable the restoration of speech perception abilities.

PI_NAMEs: BRANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Attention;audiovisual speech;Auditory;Auditory area;auditory stimulus;Auditory system;Biological;Brain;Brain Injuries;Brain Neoplasms;Classification;Cochlear Implants;Code;Compensation;Crowding;Cues;Data;density;Development;Devices;Dimensions;Distributional Activity;Electrodes;Electroencephalography;Emotional;Frequencies;Functional Magnetic Resonance Imaging;Health;healthy aging;Hearing;Human;Illusions;Impairment;improved;Individual;Lipreading;Maps;Measures;Modality;Modeling;Movement;neural prosthesis;neuromechanism;Neurons;Noise;Oral;Oral cavity;Participant;Patients;Pattern;Perception;Periodicity;Physiological Processes;Population;Presbycusis;Process;programs;Reaction Time;Recovery;Rehabilitation therapy;Research;Resolution;Resources;response;restoration;Route;sensory substitution;Shapes;Signal Transduction;social;Social Interaction;Speech;speech accuracy;Speech Perception;Speech Sound;Stimulus;Stroke;Superior temporal gyrus;System;Testing;Titrations;Training Programs;Trauma;Vision;Visual;visual information;visual speech;Vocation

PROJECT_TITLE: Characterizing the recovery of spectral, temporal, and phonemic speech information from visual cues

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: THE ROLE OF EFFEROCYTOSIS IN INFLAMMATORY ARTHRITIS Narrative  Dying cells can be detected in inflamed joints of human patients and animal models of Rheumatoid arthritis (RA), a chronic inflammatory disease which affects 1 in 100 people globally and millions in the US alone. The current dogma suggests that persistence of dying cells in tissues indicates pathology, as these cells are usually promptly removed by their live neighbors in a process called ‘efferocytosis’. In this application, we present surprising data showing that there are unappreciated benefits of reduced efferocytosis in arthritis and propose to test the dogma and explore the therapeutic potential of this process, which could open new avenues in therapeutic designs for the treatment of rheumatoid arthritis.

PI_NAMEs: ARANDJELOVIC, SANJA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TITLE: The Role of Efferocytosis in Inflammatory Arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Following our novel findings in diabetic patients with impaired kidney function, we propose a multi-disciplinary study to assess the role of circulating miRNAs and axon guidance pathway (AGP) proteins in the development of early progressive kidney function decline (PKFD) in patients with normal kidney function and to learn about the mechanisms through which circulating AGP proteins may damage the kidney. Three complementary studies will be conducted. One will examine the hypothesis in an observational study of patients with diabetes, the second will examine the same hypothesis using kidney biopsies from patients with diabetes and in non- diabetic controls, and the third will examine mechanisms of early kidney damage through genetic manipulation of circulating levels of miRNAs and AGP proteins in mice model of diabetes.

PI_NAMEs: KROLEWSKI, ANDRZEJ S (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Affect;axon guidance;biobank;circulating microRNA;Clinical;cohort;Cohort Studies;Collaborations;Data;Development;Diabetes Mellitus;Diabetic mouse;Diabetic Nephropathy;diabetic patient;Disease;End stage renal failure;EPHA2 gene;EphA2 Receptor;EPHB2 gene;Etiology;follow-up;functional decline;genetic manipulation;Genetic study;glycemic control;Human;Impairment;improved;Incidence;Insulin-Dependent Diabetes Mellitus;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Lead;Learning;Lesion;Ligands;Link;member;Methods;MicroRNAs;Molecular;mouse genetics;mouse model;multidisciplinary;Mus;Nested Case-Control Study;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;Orthologous Gene;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pima Indian;Plasma;Prevention;Probability;Process;Prognostic Marker;Proteins;Proteinuria;renal damage;Renal function;Research;Research Personnel;Resources;Risk;Role;single-cell RNA sequencing;Specimen;success;Technology;Testing;The Jackson Laboratory;therapeutic target;United States;Variant

PROJECT_TITLE: Causal connections between axon guidance proteins and early progressive kidney function decline in diabetes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Project Narrative  One intriguing function of neutrophils is their ability to expel their DNA in the form of a cobweb-like structures known as neutrophil extracellular traps (NETs) decorated with their granular antimicrobial proteins. We have obtained evidence that mice deficient in peptidyl arginine deiminase-4 (Pad4KO, aka NETs deficient) are highly susceptible to inflammatory bowel disease (IBD). This proposal seeks to address the mucoprotective roles of PAD4 mechanistically in murine models of IBD.

PI_NAMEs: VIJAY-KUMAR, MATAM  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acute;Address;Adhesions;adverse outcome;Affect;Aggravated Colitis;American;antagonist;antimicrobial;Arginine;Arginine deiminase;Awareness;bactericide;Biomass;cell type;Cells;Charge;Chronic;Citrulline;clinically relevant;Colitis;combat;Crohn's disease;CXCR4 gene;Cytoplasmic Granules;Data;Deoxyribonuclease I;Disease;disease diagnosis;DNA;Elastases;Enzymes;Excision;extracellular;first responder;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Generations;Genetic;Goals;gut bacteria;gut health;gut inflammation;Histones;Homeostasis;host microbiota;Human;Immune;Immune response;in vivo Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;interleukin-10 receptor;Intestinal Diseases;Intestines;Knowledge;LCN2 gene;Literature;Mediating;Mediator;Microbe;microbial;Modeling;Molecular;mouse model;Mucositis;Mucous Membrane;Mus;neutrophil;Neutrophilia;opportunistic pathogen;pancreatic elastase II;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Peroxidases;Phagocytes;pharmacologic;Predisposition;prevent;Proteins;Reactive Oxygen Species;Recovery;recruit;Regulation;Relapse;Reporting;Research;response;Role;Sodium Dextran Sulfate;Structure;Therapeutic;therapeutic target;translational applications;translational approach;Ulcerative Colitis;United States;wound healing

PROJECT_TITLE: Role of neutrophil extracellular traps (NETs) in Inflammatory bowel disease

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Services;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lip, oral cavity, and pharyngeal cancers are a significant health problem afflicting approximately 530,000 people globally every year. This multi-institution prospective longitudinal cohort study will assess for the first time the performance of a point-of-care oral cytology tool (POCOCT) for its use in both secondary and tertiary care settings, where high risk patients will be longitudinally monitored and their risk trajectory established over time using personalized cellular image signatures. This effort has potential for more accurate oral lesion diagnosis while improving patient survival and overall quality of life.

PI_NAMEs: MCDEVITT, JOHN T (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Actins;Agreement;Algorithmic Software;Algorithms;Artificial Intelligence;Biological Assay;Biological Markers;biomarker identification;Biopsy;cancer diagnosis;cancer recurrence;cancer risk;Carcinoma;CD34 gene;cell type;Cell-Matrix Junction;Cells;cellular imaging;Classification;Clinical;Clinical Pathways;Clinical Research;Consensus;Cytology;Cytopathology;Data;data acquisition;Data Sources;data streams;Databases;deep learning;deep learning algorithm;Dental;Diagnosis;Diagnostic;diagnostic technologies;diagnostic tool;Disease;Disease Progression;Early Diagnosis;Early identification;Epidermal Growth Factor Receptor;Evolution;Excision;experience;F-Actin;Goals;Health;high risk;Histopathology;Image;Image Cytometry;imaging agent;improved;Incidence;indexing;Individual;individual patient;insight;Institution;instrument;Intraepithelial Neoplasia;Lesion;Lip structure;Literature;Localized Malignant Neoplasm;Longitudinal cohort study;Malignant - descriptor;malignant mouth neoplasm;Malignant neoplasm of pharynx;Measurement;Measures;Medical Surveillance;Microfluidics;Modeling;Monitor;mouth squamous cell carcinoma;multimodality;National Institute of Dental and Craniofacial Research;Nuclear;Operative Surgical Procedures;oral care;Oral cavity;oral cavity epithelium;oral dysplasia;oral lesion;Pathway interactions;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;Performance;personalized diagnostics;Persons;Phenotype;Ploidies;point of care;Population;Population Surveillance;portability;predictive modeling;Predictive Value;preference;prognostic value;programmed cell death ligand 1;prospective;Prospective, cohort study;Protocols documentation;Quality of life;Questionnaires;rate of change;Recording of previous events;Recurrence;Risk;risk prediction;Sampling;scalpel;Series;Severity of illness;single cell analysis;Specimen;Speed;Surveys;System;targeted imaging;Technology;tertiary care;Time;time use;tool;Treatment outcome;Trust;Validation;Visit;Visual

PROJECT_TITLE: Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: The proposed research will help elucidate how histone variant H2A.X is incorporated into chromatin in response to DNA damage and how ubiquitylation of H2A and H2A.X by RNF168-UbcH5c triggers the recruitment of several DNA damage response proteins to damaged chromatin. This work has relevance to public health because it will provide a molecular level understanding of several factors that promote homologous recombination (HR) DNA repair and are essential to the maintenance of genome integrity and tumor suppression. Targeting HR-promoting factors for inhibition could in principle be used to potentiate poly(ADP-ribose) polymerase inhibitors (PARPi) in killing ovarian and breast cancer cells and counteract acquired resistance to PARPi treatment developed by cancer patients.

PI_NAMEs: MER, GEORGES  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: ataxia telangiectasia mutated protein;Biochemistry;BRCA1 gene;Breast Cancer Cell;Cancer Patient;Cellular biology;Chromatin;Cryoelectron Microscopy;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;Double Strand Break Repair;Equilibrium;fascinate;genome integrity;Goals;Health;Histone H2A;Histones;homologous recombination;Human;Knowledge;Lysine;Maintenance;Malignant neoplasm of ovary;Molecular;Molecular Chaperones;NMR Spectroscopy;Nonhomologous DNA End Joining;Nucleosome Core Particle;Nucleosomes;p53-binding protein 1;Pathway interactions;Phosphorylation;Play;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;programs;Proteins;Public Health;recombinational repair;recruit;Research;Resistance;response;Ring Finger Domain;Role;Site;structural biology;Testing;Tumor Suppression;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Structural biology of DNA damage response in chromatin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease

PHR: PROJECT NARRATIVE About 30 million Americans are estimated to have chronic kidney disease, which incurs healthcare cost of more than $50.4 billion annually. Accurate characterization of chronic kidney disease is essential for its management. In this study, we will develop and test a new ultrasound technology for safe, cost-effective, convenient, and accurate characterization of chronic kidney disease.

PI_NAMEs: CHEN, SHIGAO  (contact)

PROJECT_TERMS: Affect;Agreement;American;Analysis of Variance;Animals;arteriole;Benchmarking;Binding;Biopsy;Blood flow;Blood Flow Velocity;Chronic Kidney Failure;Clinical;Clinical Research;contrast enhanced;contrast enhanced computed tomography;Contrast Media;Cortical vasculature;cost effective;Decision Making;density;Development;Diameter;elastography;Euthanasia;experimental study;Family suidae;Glomerular Filtration Rate;Health Care Costs;healthy volunteer;Histology;Human;Image;Image Enhancement;imaging modality;imaging study;imaging system;Imaging technology;improved;indexing;Kidney;kidney biopsy;kidney cortex;Kidney Diseases;kidney imaging;kidney vascular structure;Length;Logistic Regressions;Magnetic Resonance Imaging;Measurement;Measures;meter;Methods;Microbubbles;microCT;Modeling;Morphology;Noise;Normal Range;novel;Outcome;Pathology;Patients;Penetration;Performance;Perfusion;perfusion imaging;Proteinuria;Random Allocation;Receiver Operating Characteristics;Reference Standards;Regression Analysis;Renal Artery Stenosis;renal damage;ROC Curve;Sampling;Scanning;Signal Transduction;Speed;Staging;Technology;technology validation;Testing;Thick;tool;Toxic effect;ultra high resolution;Ultrasonography;ultrasound;Validation;vascular bed;venule;X-Ray Computed Tomography

PROJECT_TITLE: Renal Microvessel Imaging for Characterization of Chronic Kidney Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


PHR: A major mediator of the gene-environment interactions in development of diabetes, obesity and metabolic syndrome is the gut microbiome and its impact on the circulating metabolome. To begin to dissect the role of the microbiome in gene-environment interactions in the pathogenesis of type 2 diabetes and obesity, we have developed a novel model taking advantage of three strains of laboratory mice which vary in their level of insulin resistance and development of obesity and diabetes in response to high fat diet challenge. The major goal of this project is to identify microbiota and metabolites which are altered by the changing microbiome and contribute to insulin resistance and metabolic dysregulation across these models in response to different diets and exercise; identify the highly regulated unknown metabolites that are linked to insulin resistance; and determine how both the known and the newly-identified unknown metabolites linked to insulin resistance alter insulin signaling in vitro and in vivo.

PI_NAMEs: KAHN, C RONALD (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Affect;Antibiotics;Biochemical Pathway;Breeding;Carbohydrates;Communities;Data;Development;Diabetes Mellitus;diabetes risk;Diet;diet and exercise;diet-induced obesity;Disease;Environment;Epidemic;Exercise;Fatty acid glycerol esters;fecal transplantation;Fructose;gene environment interaction;gene product;Genes;Genetic;Genetic Risk;Germ;Germ-Free;Glucose;Goals;Grant;gut microbiome;gut microbiota;High Fat Diet;Human;In Vitro;in vivo;Insulin;Insulin Resistance;insulin signaling;Laboratories;Laboratory mice;Link;Mediator;Metabolic;metabolic phenotype;Metabolic syndrome;Metabolism;metabolome;metabolomics;metagenome;Metagenomics;microbial;microbiome;microbiome alteration;microbiota;Modeling;Molecular;mouse model;Mouse Strains;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;obesity development;Pathogenesis;Phenotype;Plasma;Predisposition;Process;Production;Resistance;response;Rodent;Role;Type 2 diabetic;Weight;Work

PROJECT_TITLE: Interaction between genes, environment, the microbiome and metabolome in type 2 diabetes and metabolic syndrome

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Individuals with cystic fibrosis (CF) have chronic respiratory infections. Oral diseases like tooth decay and gingivitis are potential sources of pathogenic bacteria that could spread from the mouth to the lungs, further compromising respiratory health. The proposed study will identify risk factors for oral diseases in adolescents and young adults with CF, evaluate associations between oral diseases and measures of respiratory health, and explore microbiologic links between oral and respiratory health using cutting-edge microbiome methods.

PI_NAMEs: CHI, DONALD LESLIE (contact);ROSENFELD, MARGARET

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Age;age group;Alabama;aspirate;autosome;Bacteria;Behavior;Behavioral;Biological;Biological Factors;Carbohydrates;Caring;Cariogenic Diet;Caucasians;Cessation of life;children with cystic fibrosis;Chronic;Clinical;cohort;Cystic Fibrosis;cystic fibrosis patients;Data;Dental;Dental caries;Dental Hygiene;Dental Plaque;Dentistry;Dentists;Diagnostic;Disease;disorder prevention;dysbiosis;early adolescence;Enrollment;Environment;Epidemiology;Evidence based intervention;functional decline;General Population;Gingivitis;Health;Health behavior;high risk;Impairment;improved;Incidence;Inflammatory;Intake;Intervention;Life;Life Expectancy;Link;loss of function;Lung;Lung Diseases;lung injury;lung microbiome;Measures;Mechanical ventilation;Medical;Methods;microbiome;microbiome analysis;Modeling;Modernization;Mouth Diseases;Mucociliary Clearance;North Carolina;Obstructive Lung Diseases;Oral;oral bacteria;Oral cavity;Oral health;oral microbiome;Outcome;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Pediatric Hospitals;peer;Pneumonia;Population;premature;Prevalence;prevent;Prevention;Preventive;Preventive dental care;preventive intervention;prospective;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;randomized, clinical trials;Reflux;respiratory;respiratory health;Respiratory Tract Infections;Risk;Risk Factors;Saliva;Site;Source;Sputum;Standardization;Stomach;Streptococcus mutans;Time;Universities;Visit;Weight

PROJECT_TITLE: Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PUBLIC HEALTH RELEVANCE: Inflammatory bowel disease is a chronic relapsing and remitting condition affecting the gastrointestinal tract, which is often disabling and encumbers normal activities of daily life. The chronic and relapsing nature of IBD, in conjunction with the lack of curative therapies for many patients, enhances risk for inflammation-associated comorbidities, including intestinal fibrosis. This project seeks to understand the role of bacterial metallophores on IBD disease development and severity, which may support the development of novel therapeutic strategies for the prevention of IBD.

PI_NAMEs: SAMUELSON, DERRICK R (contact)

PROJECT_TERMS: Acceleration;Adherent Invasive Escherichia coli;Affect;Alleles;Animals;Attention;Bacteria;biobank;Biological Process;Cell division;Cell Physiology;Cessation of life;chemically induced colitis;Chronic;Clinical;Colitis;combat;comorbidity;Crohn's disease;curative treatments;Data;deprivation;Development;Diet;dietary;Dietary intake;Disabling;Disease;Disease remission;DNA biosynthesis;dysbiosis;Environmental Risk Factor;Enzymes;Epithelial Cells;Epithelium;Extracellular Matrix;gastrointestinal;Gastrointestinal tract structure;Gene Cluster;Genetic;genetic variant;genome sequencing;Growth;gut microbiota;Harvest;Health;Homeostasis;Human;immune function;Immunologic Factors;Impairment;Individual;Inflammation;Inflammatory Bowel Diseases;innovation;Intake;intestinal epithelium;Intestinal Fibrosis;intestinal homeostasis;Intestines;Knock-in;Knock-in Mouse;Life;Linear Models;Link;Maintenance;Mammals;Mediating;Mediation;Metals;microbial;microbial community;microbial composition;microbiota;Modeling;mouse model;Nature;novel;novel therapeutic intervention;Nutrient;Organoids;pathobiont;Pathogenesis;Pathway interactions;Patients;Permeability;Physiological;Population;Predisposition;Prevalence;Prevention strategy;Production;Protein Biosynthesis;Public Health;public health relevance;Recording of previous events;Regulation;Relapse;Research;Risk;Role;role model;Severities;Severity of illness;Siderophores;small molecule;Testing;Trace metal;whole genome;Wild Type Mouse;wound healing;yersiniabactin;Zinc;Zinc deficiency;zinc-binding protein

PROJECT_TITLE: Gut bacterial metallophores in the development and severity of inflammatory bowel disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Relevance  Johns Hopkins has an extraordinary institutional commitment to the health of the public. Through close collaboration across multiple disciplines, the Cancer Center is focused on the entire spectrum of cancer care from risk identification, screening and prevention to early detection and cancer treatment. This patient centered care addresses the effects of cancer on financial stability, family and social interactions and quality of life, encompassing the overall impact of cancer on the lives of patients.

PI_NAMEs: ARMSTRONG, DEBORAH K;BRAHMER, JULIE RENEE (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;American College of Radiology Imaging Network;cancer care;Cancer Center;cancer therapy;Cellular biology;Clinical;Clinical Trials;Collaborations;Contracts;Development;Discipline;Disease;Early Diagnosis;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Faculty;Family;Goals;Grant;Image;Infrastructure;innovation;Institution;Laboratories;Lead;Leadership;Location;Malignant Neoplasms;member;Minority Participation;Mission;Modality;Molecular Biology;National Clinical Trials Network;novel;novel marker;novel therapeutics;Oncology;patient population;Patient-Centered Care;Patients;Phase;pre-clinical;Prevention;programs;Public Health;Quality of life;Radiation;Research;Research Personnel;Risk;Role;screening;Site;Social Interaction;Techniques;Translational Research;Universities

PROJECT_TITLE: Johns Hopkins University NCTN Lead Academic Site Program


NIH_SPENDING_CATS: Cardiovascular;Microbiome

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Soluble epoxide hydrolase (sEH) is an important enzyme for metabolic and cardiovascular health. The proposed studies will explore a novel mechanism involving gut bacteria for sEH regulation and evaluate the performance of a new method to assess sEH activity, recently developed by the investigator team. Successful completion of the proposed studies would facilitate studies of sEH regulation in humans and lead to new therapeutic targets or strategies in the treatment of diabetes or cardiovascular diseases.

PI_NAMEs: YOUN, JANG H. (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acids;Animals;Antibiotic Therapy;Antibiotics;Arachidonic Acids;Bile Acids;Blood;blood glucose regulation;Blood Pressure;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;cost;Data;Deoxycholic Acid;Detection;Development;Diabetes Mellitus;diabetic;dietary;endothelial dysfunction;Endothelium;Enzymes;Epoxide hydrolase;Epoxy Compounds;Fatty acid glycerol esters;feeding;Genetic Polymorphism;Glycols;gut bacteria;gut microbiota;Health;Hepatic;Human;human disease;Hydrolase;improved;In Vitro;in vivo;indexing;Individual;inhibitor;Insulin Resistance;lipid mediator;Lithocholic Acid;Liver;Measurable;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methods;new therapeutic target;novel;Pathologic;Performance;Physiological;Plasma;Production;Rattus;Regulation;Research Personnel;Role;Sample Size;Secondary to;Testing;Time;Time Study;Tissues;tool;treatment effect

PROJECT_TITLE: Soluble epoxide hydrolase: assessment of in vivo activity and regulation by gut microbiota

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The goal of this project is to identify novel targets involved in protection against alcoholic fatty liver disease (AFLD) by elucidating a novel role of redox-modulated hepatic O-GlcNAc signaling in AFLD pathogenesis. Our preliminary studies show that chronic-binge ethanol feeding induces differential changes in liver global O- GlcNAcylation (a prevalent form of post-translational modification) in a mouse model of chronic oxidative stress, which may serve as a protective mechanism against alcohol-induced liver injury. We propose to examine ethanol-associated changes in hepatic O-GlcNAcylation signaling and elucidate key signaling events that are mechanistically linked to hepatoprotection.

PI_NAMEs: CHEN, YING  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Adaptor Signaling Protein;Alcohol consumption;alcohol exposure;alcohol response;Alcoholic Fatty Liver;Alcoholic Liver Diseases;Alcohols;Animal Model;Antioxidants;Autophagocytosis;biological adaptation to stress;Biological Markers;Biological Models;calmodulin-dependent protein kinase II;Categories;Cell model;Cells;Cellular Stress;Chronic;chronic liver disease;Clone Cells;Cytoplasmic Protein;cytotoxicity;Data;Diagnostic;disability-adjusted life years;Disease;Disease Management;economic impact;endoplasmic reticulum stress;Engineering;Enzymes;Ethanol;Ethanol Metabolism;Event;fatty liver disease;feeding;Fibrosis;Free Radicals;Functional disorder;GCLM gene;Generations;Genes;Glutathione;Goals;Health;Hepatic;hepatoprotective;Homeostasis;Human;in vivo;Inflammation;Insulin Resistance;Knockout Mice;Link;Liver;liver metabolism;Maintenance;Mediating;Metabolic;metabolomics;Mitochondrial Proteins;Modeling;Modification;Molecular;Molecular Toxicology;mortality;mouse model;multiple omics;Mus;nanobodies;novel;Nuclear Proteins;Nutrient;O-GlcNAc transferase;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Phosphorylation;Play;Post-Translational Protein Processing;posttranscriptional;Preventive;Process;protein function;protein profiling;protein protein interaction;Proteins;Proteome;Proteomics;Public Health;Regulation;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stress;Sulfhydryl Compounds;Testing;therapeutic target;Tissues;Toxicogenetics;transcription factor;Uridine Diphosphate N-Acetylglucosamine

PROJECT_TITLE: Redox Regulation of O-GlcNAcylation Signaling in the Pathogenesis of Alcoholic Fatty Liver Disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: The goal of this research is to develop a novel photoacoustic imaging approach that will allow non- invasive, simultaneous three-dimensional visualization of all the embryos in a mouse utero and track their birth/adulthood longitudinally to study the association between maternal alcohol exposure induced fetal hemodynamic changes and the outcome of fetal alcohol spectrum disorder (FASD) after birth. The functional focus of this proposal is on fetal cerebral artery mitochondria. Our work will provide better understanding of the pathophysiology of FASD and offer new therapeutic target(s) against this condition.

PI_NAMEs: BUKIYA, ANNA ;JIANG, HUABEI  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Adult;Affect;alcohol exposure;alcohol response;Alcohols;Animals;Arteries;Attention;Autopsy;Bioenergetics;Biological Assay;Biomedical Engineering;Birth;Blood flow;Brain;Brain hemorrhage;Brain Hypoxia-Ischemia;Brain imaging;Cells;cerebral artery;cerebral vascularization;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Characteristics;Child;Collaborations;Computer software;Congenital Abnormality;density;deoxyhemoglobin;Development;Developmental Delay Disorders;Diameter;Early Diagnosis;effective therapy;Embryo;Excision;Exhibits;extracellular;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetus;fluorescence imaging;Functional disorder;Genus Hippocampus;Goals;hemodynamics;high resolution imaging;Human;Image;Image Analysis;image reconstruction;imaging approach;Imaging Techniques;improved;in vivo monitoring;Infant;Intervention;Knowledge;Liver;maternal alcohol use;Metabolic;metabolic rate;Mitochondria;Morphology;Mus;neuron development;Neurons;new therapeutic target;novel;Nutritional;optoacoustic tomography;Organ;Outcome;Oxygen;Oxygen Consumption;Pharmacology;photoacoustic imaging;Pregnancy;Preventive measure;Proteome;Recording of previous events;reduce symptoms;Reporting;Research;Resolution;response;Rodent;Role;School-Age Population;sensor;Speed;System;Technology;Testing;Therapeutic Intervention;therapeutically effective;Three-Dimensional Image;three-dimensional visualization;tool;Uncertainty;United States;Up-Regulation;Visualization;wasting;Work

PROJECT_TITLE: Fetal alcohol exposure and cerebrovascular development

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: The NIGMS Human Genetic Cell Repository U42 Application FOA No.: RFA-GM-19-002 Project Narrative The NIGMS Human Genetic Cell Repository (HGCR) stimulates and facilitates biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by providing well-characterized and high-quality cell lines, DNA, and iPSCs for use in biomedical research. The NIGMS HGCR currently contains approximately 11,800 unique cell lines, 6,400 DNA samples, and 54 human iPSC lines representing a variety of disease states, chromosomal abnormalities, apparently healthy individuals and many distinct human populations. The NIGMS HGCR also develops and offers a wide range of cutting-edge special genetic services and biomaterials in response to the research community’s needs.

PI_NAMEs: TURAN, NAHID  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Advertisements;Area;Biocompatible Materials;Biomedical Research;Catalogs;Cell Line;cell repository;Cells;Chromosome abnormality;Clinical;Collection;Communities;computerized;Custom;Databases;Development;Diagnosis;Disease;disease diagnosis;DNA;Educational process of instructing;Electronic Mail;established cell line;Exhibits;Family;Foundations;Funding Opportunities;Genetic Diseases;Genetic Research;Genetic Services;Geography;Goals;Hereditary Disease;high standard;Human;Human Genetics;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;Information Distribution;innovation;Institutional Review Boards;interest;Interview;Journals;Life;Maintenance;Medical Research;meetings;Mission;National Institute of General Medical Sciences;Newsletter;Pamphlets;Patients;permanent cell line;Population;Preparation;Prevention;Procedures;Process;Protocols documentation;Quality Control;Reporting;repository;Research;Research Personnel;Research Support;Resources;response;RNA;Sampling;Secure;Services;social media;Technology;Testing;Update

PROJECT_TITLE: The NIGMS Human Genetic Cell Repository


NIH_SPENDING_CATS: Genetics;Human Genome

PI_NAMEs: REQUESENS, DEBORAH  (contact)

PROJECT_TERMS: Advertisements;Area;Biocompatible Materials;Biomedical Research;Catalogs;Cell Line;cell repository;Cells;Chromosome abnormality;Clinical;Collection;Communities;computerized;Custom;Databases;Development;Diagnosis;disease diagnosis;DNA;Educational process of instructing;Electronic Mail;established cell line;Exhibits;Family;Foundations;Funding Opportunities;Genetic Diseases;Genetic Research;Genetic Services;Geography;Goals;Hereditary Disease;high standard;Human Genetics;human induced pluripotent stem cells;Individual;Information Distribution;innovation;Institutional Review Boards;interest;Interview;Journals;Life;Maintenance;Medical Research;meetings;Mission;National Institute of General Medical Sciences;Newsletter;Office of Administrative Management;Pamphlets;Patients;permanent cell line;Preparation;Prevention;Procedures;Process;Protocols documentation;Quality Control;Reporting;repository;Research Personnel;Research Support;Resources;response;RNA;Sampling;Secure;Services;social media;Technology;Testing;Update

PROJECT_TITLE: Scientific and Administrative Management Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Infection by the parasite Toxoplasma gondii is widespread and it contributes to illness due to congenital infection and people with weakened immune systems. Although treatment is available to control infection, it is not able to eliminate the chronic stages, leaving individuals at risk of serious disease when infections reactivate. The goal of our studies is to develop new small molecule inhibitors that can eliminate the chronic stages and thus cure infection.

PI_NAMEs: JANETKA, JAMES W;SIBLEY, L. DAVID (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Achievement;Acute;acute infection;Allergic Reaction;analog;Animal Model;Binding;Biological Assay;Biological Availability;calcium-dependent protein kinase;Cells;Central Nervous System;chemotherapy;Chronic;chronic infection;Clinic;congenital infection;Cyst;Data;design;Disease;Drug Kinetics;efficacy testing;Enzymes;Eye diseases;Family;Future;Gatekeeping;Glycine;Goals;Growth;Human;immune function;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infant;Infection;Infection Control;inhibitor;Laboratories;Lead;Mammalian Cell;Metabolism;Monitor;mouse model;Mus;opportunistic pathogen;Oral;Parasites;Parasitic infection;Penetration;Persons;Pharmaceutical Preparations;Phase;Phosphotransferases;Plants;Plasma;Positioning Attribute;pre-clinical;Pregnancy;preservation;Property;Pyrimethamine;Recurrence;Resistance development;Risk;Safety;Severities;small molecule;small molecule inhibitor;South America;Specificity;src-Family Kinases;sulfa drug;Sulfadiazine;Teratogens;Testing;Tissues;Toxic effect;Toxoplasma gondii;toxoplasmic encephalitis;Toxoplasmosis

PROJECT_TITLE: Optimizing CDPK1 inhibitors for chronic toxoplasmosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Q(83)]


PROJECT_TERMS: Advertisements;Area;Biocompatible Materials;Biomedical Research;Catalogs;Cell Line;cell repository;Cells;Chromosome abnormality;Clinical;Collection;Communities;computerized;Custom;Databases;Development;Diagnosis;disease diagnosis;DNA;Educational process of instructing;Electronic Mail;established cell line;Exhibits;Family;Foundations;Funding Opportunities;Genetic Diseases;Genetic Research;Genetic Services;Geography;Goals;Hereditary Disease;high standard;Human Genetics;human induced pluripotent stem cells;Individual;Information Distribution;innovation;Institutional Review Boards;interest;Interview;Journals;Life;Maintenance;Medical Research;meetings;Mission;National Institute of General Medical Sciences;Newsletter;Online Systems;Pamphlets;Patients;permanent cell line;Preparation;Prevention;Procedures;Process;Protocols documentation;Quality Control;Reporting;repository;Research Personnel;Research Support;Resources;response;RNA;Sampling;Secure;Services;social media;Technology;Testing;Update

PROJECT_TITLE: Database and Web-Based Catalog Core


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

PROJECT_TERMS: Advertisements;Area;Biocompatible Materials;Biomedical Research;Catalogs;Cell Line;cell repository;Cells;Chromosome abnormality;Clinical;Collection;Communities;computerized;Custom;Databases;Development;Diagnosis;disease diagnosis;DNA;Educational process of instructing;Electronic Mail;established cell line;Exhibits;Family;Foundations;Funding Opportunities;Genetic Diseases;Genetic Research;Genetic Services;Geography;Goals;Hereditary Disease;high standard;Human Genetics;human induced pluripotent stem cells;Individual;Information Distribution;innovation;Institutional Review Boards;interest;Interview;Journals;Life;Maintenance;Medical Research;meetings;Mission;National Institute of General Medical Sciences;Newsletter;Pamphlets;Patients;permanent cell line;Preparation;Prevention;Procedures;Process;Protocols documentation;Quality Control;Reporting;repository;Research Personnel;Research Support;Resources;response;RNA;Sampling;Secure;Services;social media;Technology;Testing;Update

PROJECT_TITLE: Resource Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Hearing Loss;Neurosciences;Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Hearing loss due to genetic and environment factors is America's leading disability and imposes a grave social and economic burden. Defects in the actin-based hair bundle, the sound sensors in the ear, are a common cause for hearing impairment. The proposed work will identify novel secreted factors and cytoskeletal regulators with crucial functions in controlling the normal structure of the hair bundle. Ultimately, this new knowledge will facilitate the design of rational therapies to stimulate hair bundle repair following injury, to treat specific forms of hereditary human deafness and to regenerate functional auditory hair cells through stem cell technologies.

PI_NAMEs: LU, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Actins;Alleles;Apical;Auditory;beta catenin;Cell Culture Techniques;Cells;cellular microvillus;Cilia;Cochlea;Cochlear duct;conditional knockout;Cytoskeleton;Data;deafness;Defect;Development;disability;Disease;Ear;Economic Burden;Embryonic Development;Ensure;Environment;Environmental Risk Factor;Epithelium;Equilibrium;Foundations;Functional Regeneration;G-Protein Signaling Pathway;gain of function;Genes;Genetic;genetic deafness;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Hair;hair cell regeneration;Hair Cells;Hearing;hearing impairment;Heterotrimeric GTP-Binding Proteins;Human;Image;In Vitro;in vivo;Inherited;Injury;insight;Kinocilium;Knock-out;Knockout Mice;Knowledge;Lateral;Ligands;Link;loss of function;Maintenance;Mammals;mechanotransduction;Medial;Mediating;Medical;Membrane;Microtubules;migration;Molecular;Morphogenesis;morphogens;Morphology;Motor;mutant;Mutant Strains Mice;Names;Natural regeneration;neural;novel;Organelles;Pathway interactions;Pattern;Peripheral;permanent hearing loss;Phenotype;Phosphatidylinositols;Phosphotransferases;planar cell polarity;Positioning Attribute;programs;protease-activated receptor 3;protein activation;Proteins;Publishing;rational design;receptor;recruit;Regulation;repaired;Role;Scaffolding Protein;sensor;Sensorineural Hearing Loss;Sensory Hair;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;social;sound;stem cell technology;Stereocilium;Structure;Testing;Therapeutic;Tissues;Transducers;WNT Signaling Pathway;Work

PROJECT_TITLE: Microtubule-mediated mechanisms underlying hair cell development and deafness

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Genetic diversity is central to the biology of human health and disease but is often overlooked when developing tractable disease models. Thus, to accelerate our understanding of the relationship between genetic variation and phenotypic heterogeneity—and to explore building more accurate and representative cell-based models with which to interrogate this relationship— we propose to hold a multi-disciplinary scientific conference that connects junior and senior researchers from the genetics and genomics, cell biology, and bioinformatics fields and focuses on pluripotent stem cells as an important model for human disease, human genetic diversity, and as a potential future tool for personalized regenerative medicine. The conference will promote networking and multi-disciplinary collaboration, and will inform and train junior investigators in state-of-the-art genetic and bioinformatic approaches for conducting rigorous studies that utilize and leverage human and murine pluripotent stem cells.

PI_NAMEs: BAKER, CHRISTOPHER LEE (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Active Learning;Address;Adopted;Attention;Automobile Driving;Award;Awareness;Bioinformatics;Biological;biomedical resource;career;career development;Cell Differentiation process;Cell Line;Cell model;Cell Therapy;Cells;Cellular biology;Collaborations;Communities;Community Developments;Computer Analysis;Creativeness;Data;design;Development;directed differentiation;Discipline;Disease;disease model;Disparity population;Educational workshop;Engineering;Ensure;Environment;Equity;Ethics;Ethnic Origin;Faculty;Fostering;functional genomics;functional outcomes;Funding;Future;Genetic;genetic analysis;genetic approach;Genetic Diseases;Genetic Research;Genetic Variation;genome wide association study;Genomics;Goals;Grant;Health;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;Human Biology;Human Cell Line;human disease;Human Genetics;human model;Hybrids;In Vitro;induced pluripotent stem cell;interdisciplinary collaboration;Interdisciplinary Study;Laboratories;Medical;Medicine;Mentorship;Methodology;Methods;Modeling;Molecular;Mouse Embryonic Stem Cells;mouse genetics;multidisciplinary;Mus;Mutant Strains Mice;Nature;next generation;Patient Recruitments;personalized therapeutic;Persons;Phenotype;pluripotency;Pluripotent Stem Cells;Population;Population Heterogeneity;precision genetics;Problem Solving;programs;Public Health;Published Comment;rational design;Reagent;Recording of previous events;Recruitment Activity;Regenerative Medicine;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Research Project Summaries;Resource Development;Resource Sharing;Resources;response;Scholarship;Science;Scientist;screening;skill acquisition;Statistical Methods;stem cell biology;Stem Cell Research;stem cells;Study models;symposium;System;Technical Expertise;Technology;Teratoma;The Jackson Laboratory;Tissues;tool;Training;Travel;Underrepresented Populations;Undifferentiated;United States National Institutes of Health;Variant;virtual;Work

PROJECT_TITLE: Diversity in a Dish: Pluripotent Stem Cells in Genetic Analysis and Disease Modeling


ORG_CITY: CORAL GABLES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative: Metabolism is a renewed target in cancer, and perhaps no cancer is better suited for metabolic therapies than ccRCC, which is refractory to traditional chemo and radiotherapies, and develops resistance to the targeted agents that are current frontline therapies. Here we propose to investigate a molecular mechanism of the hallmark sign of ccRCC, lipid accumulation, as a biomarker and novel target.

PI_NAMEs: WELFORD, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adipocytes;adipokines;Allografting;angiogenesis;Animal Model;autocrine;Automobile Driving;Biological Markers;cancer risk;Carnitine Palmitoyltransferase I;Catabolism;Cell Death;Cell Line;Cells;Cessation of life;Characteristics;chemotherapy;Clear cell renal cell carcinoma;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cytometry;Cytoplasm;Data;Deposition;deprivation;Development;Diagnostic;Dose;Endocrine Glands;Epidemiology;Fatty acid glycerol esters;fatty acid transport;gene repression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Glycogen;Glycolysis;High Fat Diet;Histologic;Human;Hypoxia Inducible Factor;Image;Immunocompetent;improved;in silico;Incidence;Inflammatory;Intervention;Invaded;Iron;KDR gene;Knockout Mice;Lead;Lesion;Link;lipid biosynthesis;lipid metabolism;Lipids;Malignant Neoplasms;Mediating;Metabolic;Metabolic syndrome;Metabolism;Mitochondria;Modeling;Molecular;Monitor;Monoclonal Antibodies;multiple omics;Mus;Nature;Neoplasm Transplantation;neoplastic cell;novel;novel strategies;novel therapeutics;Obesity;Oncogenic;Outcome;overexpression;oxidation;paracrine;Pathogenesis;Patient-Focused Outcomes;Patients;PF4 Gene;Pharmacology;Phenotype;pre-clinical;prevent;Production;prognostic;Protein Isoforms;Protein Tyrosine Kinase;Radiation therapy;receptor;Refractory;Regimen;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Resistance development;response;restoration;Risk Factors;Role;Sampling;Signal Transduction;small hairpin RNA;Specimen;standard of care;Stress;System;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutically Targetable;Tissues;Toxic effect;transdifferentiation;tumor;tumor growth;tumor metabolism;Tumor Promotion;Tumor Suppressor Proteins;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Adipokine Signaling as a Therapeutically Targetable Driver of Tumor Metabolism

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]