NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Teacher Enrichment Initiatives: “It’s Contagious! Promoting the Biomedical Workforce Pipeline through Infectious Diseases” aims to establish a novel model to promote the growth of a diverse future STEM education and workforce pipeline. Teacher and student participants in the programs proposed will be recruited from diverse San Antonio districts. Promoting data literacy in teachers through a Teachers as Researchers Program and engaging students in Classroom to Career Connections activities and supplemental narratives showcasing infectious disease research and diversity in biomedical careers, the program has great potential to enhance the future biomedical workforce of our nation as teachers promote diversity in the biomedical sciences and foster increased understanding of career opportunities available to their K-12 student within biomedicine.

PI_NAMEs: RIGGS, ROSEMARY  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Address;Affect;Applied Skills;Area;Awareness;Biological Sciences;Biomedical Research;biomedical scientist;career;career awareness;cohort;college;Communicable Diseases;Community of Practice;Country;Data;Data Analyses;data literacy;Databases;design;Development;disease transmission;Education;Educational process of instructing;empowerment;experience;Exposure to;Fortification;Fostering;Funding;Future;Growth;high school;High School Faculty;High School Student;Hispanic;Hispanic Populations;Industry;Infectious Diseases Research;innovation;Instruction;interest;Intervention;K-12 student;Knowledge;Latinx;Leadership;Learning;Measures;Minority;Mission;Modeling;next generation;novel;Outcome;Participant;pedagogy;Peer Review;Population;Privatization;Program Development;programs;recruit;Research;research facility;Research Institute;Research Personnel;role model;Science;science teacher;Science, Technology, Engineering and Mathematics Education;skills;skills training;statistics;STEM career;student participation;Students;teacher;Teacher Professional Development;Texas;tool;Training;vaccine development;workforce needs

PROJECT_TITLE: It's Contagious!  Promoting the Biomedical Workforce Pipeline through Infectious Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: EL PASO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE Flaviviruses are important human pathogens, the clinical outcomes of their infections are unpredictable, and not specific treatment is available. We propose here to characterize an anti-flavivirus innate immune mechanism that potentially will identify biomarkers of disease susceptibility and novel therapeutic targets.

PI_NAMEs: LLANO, MANUEL  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3T3 Cells;Adult;Biological Markers;biomarker identification;Biomedical Research;Bioterrorism;Cell Line;cell type;Cells;Classification;Clinical;Codon Nucleotides;cytokine;Cytomegalovirus;Dengue Virus;Disease susceptibility;Education;Ethnic Population;experimental study;Family;Flavivirus;Flavivirus Infections;Genes;Glioblastoma;graduate student;Hispanic;Human;human model;human pathogen;Immune response;Immunocompetent;Impairment;In Vitro;in vivo;in vivo evaluation;Infection;innate immune mechanisms;Interferon Type I;Interferons;Investigation;knock-down;Knowledge;Length;Mammals;Measurement;Measures;Mediating;member;Molecular;mouse model;Mus;Mutagenesis;new therapeutic target;NIH 3T3 Cells;NIH Mouse;novel;Organ;Orthologous Gene;Outcome;overexpression;Population;Predisposition;prevent;Proteins;Reporting;Research;Research Training;response;Rift Valley fever virus;Role;Severity of illness;Specificity;Structural Protein;Students;System;therapeutic target;Time;Transfer RNA;undergraduate student;Underrepresented Populations;vaccine access;Vesicular stomatitis Indiana virus;Viral;Viral Load result;Viral Physiology;Virion;Virus;Virus Diseases;Virus Replication;West Nile viral infection;West Nile virus;Zika Virus

PROJECT_TITLE: In vivo relevance of the Schlafen-mediated innate immune mechanism in flavivirus infection


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Relevance MYC is a central driver of cancers and is a validated drug target, however, no MYC-targeted therapeutic is available despite over 35 years of pursuit because the MYC protein is considered “undruggable”. The MYC promoter G-quadruplex represents a novel target for MYC inhibition; the indenoisoquinolines provide an excellent clinically tested scaffold and the DDX5-MycG4 interactions represents a novel target for inhibiting MYC. If successful, our study will have important impact because it lays the groundwork to develop new anticancer drugs with MYC-targeted activity.

PI_NAMEs: SINTIM, HERMAN O;YANG, DANZHOU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Affinity;analog;Antineoplastic Agents;Binding;Biological;Biological Assay;biophysical techniques;cancer cell;Cellular Assay;Clinical;Complex;Data;design;Development;DNA;DNA-Protein Interaction;Docking;drug action;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Fluorescence Resonance Energy Transfer;functional group;Future;G-Quartets;Gene Expression;Genes;Genetic Transcription;Goals;helicase;Human;improved;In Vitro;in vivo;inhibitor;insight;Lead;Libraries;Luciferases;Malignant Neoplasms;meter;Molecular;Molecular Target;MYC Family Protein;MYC gene;novel;novel anticancer drug;Outcome;Pharmaceutical Preparations;Positioning Attribute;Preclinical Testing;promoter;Property;Proteins;Quantitative Reverse Transcriptase PCR;rational design;Reporter;Repression;Research;scaffold;screening;Small Interfering RNA;small molecule;Structure;Structure-Activity Relationship;targeted treatment;Testing;Topoisomerase Inhibitors;Transcriptional Activation;Transcriptional Silencer Elements;Work

PROJECT_TITLE: Targeting MYC promoter G-quadruplex for MYC inhibition by Indenoisoquinolines

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Los Angeles

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE - “Chemical Tools for the Investigation and Manipulation of Protein Glycosylation” Glycoproteins represent a large fraction human proteins that become modiﬁed by carbohydrates. The structure and levels of these carbohydrates often change in diseases, but the exact nature of these changes and how they aﬀect the underlying biology of diseased cells are extremely diﬃcult to determine with existing technologies. The goal of this project is to create new, facile tools that can be used by the broad scientiﬁc community where they can be applied to a range of biomedical investigations in the future.

PI_NAMEs: PRATT, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Osteoporosis;Pediatric

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Phosphate and phosphate transporter PiT-2 are important in bone and tooth development. This grant will explore the role and mechanisms of PiT-2 in hard tissue development and repair, aiming to identify therapeutic targets.

PI_NAMEs: WALCZAK, PHILIP ADAM (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;Ameloblasts;Amelogenesis;American;Animal Model;Animals;Apoptosis;Award;Basal Ganglia;Biomedical Engineering;biomineralization;bone;Bone Density;Bone Development;Bone Growth;calcification;Calcium;calcium phosphate;career;Cell Differentiation process;Cell Physiology;cell type;Cells;Chondrocytes;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Compressive Strength;Congenital Abnormality;CRISPR/Cas technology;Critical Thinking;Data;Data Analyses;Dental Enamel;Dentin;Dentin Formation;Dentinogenesis;Dentistry;Development;Disease;Doctor of Philosophy;Education;Enamel Formation;Engineering;experimental analysis;Experimental Designs;experimental study;extracellular;Faculty;fetal;Fracture;Frequencies;Future;Genes;Grant;Growth;Health Sciences;Histology;Homeostasis;Human;Hydroxyapatites;Impaired healing;Impairment;improved;in vivo;Incisor;Injury;inorganic phosphate;Inorganic Phosphate Transporter;insight;Knock-out;Knockout Mice;Laboratories;Leadership;Learning;Measures;Mentors;Mentorship;Methods;microCT;mineralization;Molecular;Morphogenesis;mouse model;multidisciplinary;Mus;mutant;Mutation;novel therapeutics;Odontoblasts;Odontogenesis;Oral health;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteopenia;Osteoporosis;Patients;Phosphorus;Physiologic calcification;Pilot Projects;Positioning Attribute;Process;Proliferating;Protocols documentation;Publications;Reading;Regulation;repaired;Reporting;Research;Resources;Role;sensor;Signal Transduction;Skeletal Development;skeletogenesis;Skeleton;skills;Sodium;spatiotemporal;Specificity;Techniques;Technology;tenure track;therapeutic development;therapeutic target;Time;Tissues;Tooth structure;Training;Transgenic Mice;Transmission Electron Microscopy;Universities;Vascular calcification;Vesicle;Washington;Work;Writing

PROJECT_TITLE: Characterization of sodium dependent phosphate transporter 2 signaling in hard tissue mineralization

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Osteoarthritis affects members of almost every family in the United States. This project will examine gene expression patterns at tissue and single cell levels and regulatory mechanisms that characterize cartilage homeostasis and osteoarthritis in human knees. Data and insight generated from this proposal will provide new and important insights into the pathobiology and osteoarthritis, lead to new biomarkers, and identify more promising targets for therapeutic interventions to prevent or treat osteoarthritis.

PI_NAMEs: LOTZ, MARTIN K (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Activation Analysis;Adult;Affect;Age;Aging;aging population;arthropathies;articular cartilage;Binding;Binding Sites;Biological Assay;Biological Markers;Cartilage;Cell model;Cells;Chondrocytes;Clinical Trials;Code;Data;Data Analyses;Data Set;Degenerative polyarthritis;Development;Disease;Distal;Drug Targeting;Enhancers;Event;Experimental Models;experimental study;Family;Gene Abnormality;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genome-wide analysis;global run on sequencing;Histologic;Homeostasis;Human;In Vitro;in vivo;insight;Intervention;Joints;Knee;Knee joint;Lead;Libraries;Link;Mediating;member;Molecular;mRNA Expression;mRNA sequencing;Multiomic Data;novel;overexpression;Pain management;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Pre-Clinical Model;preclinical study;Prevalence;prevent;Process;protein expression;Proteins;Regulation;RNA;Role;Severity of illness;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Tissue Donors;Tissues;Transcript;transcription factor;transcriptome;transcriptomics;United States;Validation;virulence gene;Virus

PROJECT_TITLE: Integrative Omics analysis of human cartilage in aging and osteoarthritis


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Small RNAs are critical regulators of gene expression and genome organization, pathways that are highly conserved across eukaryotic phylogeny. The goal of this project is to elucidate the fundamental mechanisms of RNA silencing so we can better understand its role in human development and disease. In particular, a critical function of small RNAs is transposon silencing, which, if unregulated represents a major threat to genome integrity and is associated with infertility, birth defects, cancer, and other diseases.

PI_NAMEs: PHILLIPS, CAROLYN MARIE (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Binding Proteins;Caenorhabditis elegans;Cells;Cellular biology;cofactor;Congenital Abnormality;Cytoplasmic Granules;Developmental Biology;Disease;Eukaryota;experimental study;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genome integrity;Germ Cells;Goals;Human;Human Biology;Human Development;human disease;Infertility;Malignant Neoplasms;Messenger RNA;Methylation;Microscopy;Nuclear;Nucleotides;Pathway interactions;Phase;Phosphorylation;Phylogeny;Physical condensation;Play;Post-Transcriptional Regulation;Post-Translational Protein Processing;Proteins;Regulator Genes;Regulatory Pathway;RNA;RNA Degradation;RNA Interference;Role;Small RNA;Sorting;Specificity;Structure;System;Time;tool;Translational Repression;Work

PROJECT_TITLE: Regulation of gene expression and genome organization by small RNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This research study uses DNA sequencing to find a diagnose for families with children with a rare disease who may not be able to afford DNA sequencing studies. We use clinical testing, followed by more extensive computer technology and genetic research using the fruit fly Drosophila melanogaster to study genetic variation in patients with rare and undiagnosed disease. The study will allow new insights and a better understanding of rare diseases which often provide insights into common disease as well.

PI_NAMEs: BELLEN, HUGO J (contact);WANGLER, MICHAEL FRANCIS

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: actionable mutation;Affect;American;Artificial Intelligence;Attitude;Bioinformatics;bioinformatics tool;Biological Assay;Candidate Disease Gene;Caring;Child;Clinic;Clinical;cohort;college;computer scientist;Computers;cost;Data;Databases;design;Diagnosis;diagnostic tool;Disease;DNA;DNA sequencing;Drosophila genus;Drosophila melanogaster;Enrollment;ethnic minority;exome;exome sequencing;experience;Expert Systems;Explosion;Family;follow-up;Future;gene discovery;gene function;Genes;Genetic Counseling;Genetic Diseases;genetic disorder diagnosis;Genetic Research;Genetic study;Genetic Variation;Genome;genomic data;Genomic medicine;Genomics;Goals;Grant;Health Insurance;Healthcare;Hospitals;Human;Human Genetics;Individual;Informatics;innovation;insight;Insurance;Insurance Coverage;interest;low socioeconomic status;Machine Learning;Medical;Medical Genetics;medical schools;Medicine;Minority Groups;model organism;Modeling;Molecular Genetics;National Human Genome Research Institute;network models;novel;operation;Parents;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Perception;personalized genomics;personalized medicine;Persons;Play;Population;proband;programs;protein function;psychologic;public health insurance;Rare Diseases;Recommendation;recruit;Reporting;Research;research clinical testing;Research Personnel;research study;Role;screening;social;Societies;success;Technology;Testing;Texas;Time;tool;Training;Underserved Population;Validation;Variant;virtual visit;Work

PROJECT_TITLE: Genomic medicine and gene function implementation for an underserved population


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Pediatric;Prevention;Teenage Pregnancy;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: 8. Project Narrative Young women between the ages of 18 and 22 have high rates of undesired pregnancy and many interventions designed to reduce undesired pregnancy rates rely on faith-based approaches. In this project, we will assess whether highly religious young people differ from their less-religious peers in terms of their sexual behavior and contraceptive use, and how those differences work together to influence the risk of young pregnancy.

PI_NAMEs: BARBER, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Abstinence;adjudication;Adolescent;Adolescent and Young Adult;Affect;Age;Attitude;Barbering;Baseline Surveys;Beginning of Life;Behavior;behavior influence;Belief;Bible;cohort;Coitus;condoms;Conservatism;Contraception Behavior;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Contraceptive Usage;Data;Data Analyses;data resource;Data Set;design;Dimensions;discrete time;economic implication;Ejaculation;Event History Analysis;Faith;family structure;Frequencies;Fright;Funding;Goals;Health;Heterosexuals;High-dimensional Modeling;Hormonal;hormonal contraception;improved;Income;innovation;Intervention;Journals;Life;Linear Regressions;Link;Logistic Regressions;longitudinal dataset;male;Measurement;Measures;Methods;Modeling;Outcome;Paper;Parenting Education;peer;Peer Review;penis;Personal Satisfaction;Persons;Play;population based;Pregnancy;Pregnancy Rate;Probability;Publishing;Religion;Religiosity;reproductive;Research;Respondent;Risk;Role;Services;sex;Sex Behavior;Sex Education;Sexually Transmitted Diseases;social;Social Controls;social implication;Social Interaction;Statistical Models;Surveys;theories;therapy design;Time;transition to adulthood;unintended pregnancy;United States National Institutes of Health;Vagina;Withdrawal;Woman;Work;young woman;Youth

PROJECT_TITLE: Multi-Dimensional Religiosity and Pregnancy-Related Behaviors during the Transition to Adulthood

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE The LSU MARC program addresses the shortage of trained underrepresented, disabled, and/or economically disadvantaged students in biomedical and behavioral research fields. To close the educational achievement gap and build pathways to generate a highly skilled and diverse biomedical workforce, the LSU MARC program provides holistic, student centered spectrum of educational activities, training opportunities, professional experiences, and personal development that will prepare underrepresented groups for undergraduate and doctoral biomedical degrees and for careers as leading biomedical researchers.

PI_NAMEs: VICENTE, MARIA DA GRACA HENRIQUES (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Advisory Committees;Award;Behavioral Sciences;Biomedical Research;career;career development;CCL7 gene;cohort;Committee Members;Communities;Community Outreach;Counseling;curriculum development;design;Development;disabled;Doctor of Medicine;Doctor of Philosophy;economic disparity;Educational Activities;Engineering;Enrollment;Ensure;equity, diversity, and inclusion;Evidence based practice;experience;Faculty;faculty mentor;field trip;Goals;gulf coast;improved;Individual;innovation;Laboratories;Leadership;Louisiana;Mathematics;matriculation;mentoring community;Mentors;Modeling;National Institute of General Medical Sciences;Outcome;outreach;Participant;Positioning Attribute;Productivity;programs;Publications;Research;research and development;Research Training;Scholars Program;Science;Scientist;Site Visit;skills;Social Development;Students;success;summer research;symposium;Training;training opportunity;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Maximizing Access to Research Careers at Louisiana State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: BOSTON

ORG_NAME: JUDGE BAKER CHILDREN'S CENTER

ORG_STATE: MA

PHR: 8. NARRATIVE Mental illness is a major health problem; The Stuart T. Hauser Research Training Program in Biological Psychiatry and Social Psychiatry provides research and mentor-mentee opportunities, as well as core and individualized curricula, that are critical for developing the next generation of scientists in biological, developmental, and translational psychiatry. This program, ending its 42th year, will train the most diverse and talented young investigators, and equip them with the tools and knowledge needed to succeed in developing their own research so that they can better understand, treat, and ultimately prevent and possibly cure mental illness. The relevance of the program is that we need to improve the health care of those with mental illnesses and this can only be done by investing in the next generation of clinical researchers who will make mental illness more tractable via novel discoveries that lead to improved treatment.

PI_NAMEs: KUBICKI, MAREK ;SHENTON, MARTHA E. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Biological Psychiatry;Research Training;Social Psychiatry;Training Programs

PROJECT_TITLE: Stuart T. Hauser Research Training Program in Biological and Social Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The need for rigorously trained statistical scientists and data scientists in cancer research is massive and continues to increase. In addition to advanced coursework in biostatistics and epidemiology the interdisciplinary training program will give trainees who are obtaining a Ph.D. in Biostatistics or Epidemiology (i) a solid understanding of cancer biology, (ii) experience and ability to communicate and collaborate with cancer scientists, (iii) understanding of recent developments in cancer requiring innovative statistical research and (iv) independent research skills. The aim of the University of Michigan Cancer Biostatistics Training Program (CBTP) is to increase the participation in cancer research of the new generation of biostatisticians who are educated not only in the powerful methods of modern statistics and data science, but also in the biology and epidemiology of cancer, the current body of knowledge about the etiology of the disease, its prevention, detection, natural history, and treatment.

PI_NAMEs: BALADANDAYUTHAPANI, VEERABHADRAN  (contact);KIDWELL, KELLEY MCLAIN;TAYLOR, JEREMY M.G.

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Biostatistics Training Program in Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Clinical Research;Mental Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The goal of this training program is to train psychological clinical scientists to conduct research that will promote the scientific and training priorities of NIMH and enhance the public health. Clinical psychologists are well-qualified to promote the translation of research findings to the clinical setting in meaningful ways because they have been in the forefront of the development of efficacious treatments that incorporate evidence-based mechanisms associated with specific psychopathology. This training program seeks to capitalize on the unique foundational skill set of clinical psychologists and to further equip these scientists to make meaningful scientific contributions to enhance mental health across the lifespan.

PI_NAMEs: LEVINE, MICHELE D (contact)

PROJECT_TITLE: Clinical Research Training for Psychologists


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Clonal hematopoiesis of indeterminate potential (CHIP) arises from aging-associated acquired mutations in hematopoietic stem cells that expand in the bone marrow giving rise to white blood cells with increased inflammatory activity. This project investigates the hypothesis that CHIP driven by DNMT3A mutations increases the severity of periodontal disease. If confirmed, this knowledge has medical significance: screening of the elderly for CHIP may identify individuals with increased risk for periodontal disease and such patients may benefit from preventive treatments aiming to block the aberrant expansion of CHIP mutant clones and their harmful impact on periodontal disease.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Affect;age effect;age related;Aging;aging related;Atherosclerosis;bone loss;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cardiovascular Diseases;Cells;Chronic Disease;Circulation;Clinical;clinically relevant;clinically significant;Clonal Expansion;Clonality;comorbidity;design;DNA Modification Methylases;DNMT3a;Dominant-Negative Mutation;Effector Cell;Elderly;Engineering;Enzymes;Epidemiology;Epigenetic Process;Etiology;experimental study;FRAP1 gene;Generations;Genes;Gingiva;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;Heterozygote;Human;human old age (65+);Impairment;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Intervention;Investigation;Knowledge;Leukocytes;Ligature;Link;Medical;Methylation;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;Myeloid Cells;neutrophil;Older Population;osteoclastogenesis;Osteoclasts;Patients;Periodontal Diseases;Periodontitis;Periodontium;peripheral blood;pre-clinical;Pre-Clinical Model;Preventive treatment;PTPRC gene;recruit;Regulatory T-Lymphocyte;Resolution;Risk;Risk Factors;screening;self-renewal;Severities;Severity of illness;Signal Transduction;Sirolimus;Somatic Mutation;System;Testing;therapy development;Tissues;Transplantation;Treatment Protocols

PROJECT_TITLE: Clonal hematopoiesis and periodontal disease

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Genetics;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: BOCA RATON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Using a patient centered approach, our studies reveal a potential protective player that may influence one or more astrocyte functions critical for support of neuronal functions in the context of migraine. Accordingly, this proposal seeks to understand how the GPR37L1 signaling pathway conveys this protective function using an innovative combination of genetic, biochemical, electrophysiological, and animal modeling approaches. Ultimately, we expect the findings will identify new avenues for improving prevention and treatment of migraine, for which current medicines are inadequate for a large segment of the population.

PI_NAMEs: CIPPITELLI, ANDREA  (contact);ROBISHAW, JANET D

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Address;Adult;Affect;allodynia;Animal Model;Animals;Antibodies;anxiety-like behavior;Astrocytes;Attention;base;Behavioral;Biochemical;Biological;Biological Process;Brain;Brain region;Calcitonin Gene-Related Peptide;Cephalic;Chronic;cingulate cortex;Classification;clinical diagnosis;clinically significant;Coculture Techniques;Code;cohort;comorbidity;Data;Disease;Electrophysiology (science);Endothelin Receptor;Exhibits;experimental study;Exposure to;Family;Female;Functional disorder;Future;Gene Targeting;Genetic;genetic variant;Genetic Variation;genome wide association study;Glial Fibrillary Acidic Protein;Glutamates;GPR37 receptor;GTP-Binding Proteins;Headache;Heritability;Hippocampus;Homeostasis;Human;Human Genetics;Hypothalamic structure;Immunohistochemistry;Impairment;improved;In Situ Hybridization;In Vitro;in vivo;Incidence;Injections;innovation;Knockout Mice;Ligands;Location;male;Measures;Medicine;Membrane;Messenger RNA;midbrain central gray substance;Migraine;migraine treatment;Modeling;mouse model;mRNA Expression;multi-electrode arrays;Mus;Nervous System Disorder;Neurons;neuropathology;new therapeutic target;novel;oligodendrocyte progenitor;Orphan;Pain;pain-related disability;Pathogenesis;patient oriented;patient population;Patients;PDGFRA gene;Phenotype;Photophobia;Platelet-Derived Growth Factor alpha Receptor;Play;Population;Predisposition;Prevention;protein expression;rare variant;receptor;Resolution;response;Role;sensor;Sequence Homology;sex;Sex Bias;sexual dimorphism;Signal Pathway;Signal Transduction;Structure;Structure of trigeminal ganglion;Thalamic structure;Trigeminal Nuclei;Variant;Western Blotting

PROJECT_TITLE: The involvement of GPR37L1 on a chronic migraine-like state

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 DPI-7 (03)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Compared to the general aging population, older persons with HIV (PWH) experience higher rates of chronic aging-related conditions, including frailty, diabetes (DM), and cardiovascular disease (CVD) The proposed research will examine longitudinal associations between levels of soluble biomarkers of the Senescence-Associated Secretory Phenotype (SASP) and frailty, DM, and CVD among a cohort of older PWH. The findings from this study will provide pilot data regarding potential biomarkers associated with development of frailty, DM, and CVD that can also be used in future interventional trials using senotherapeutic agents to prevent or alleviate these conditions in PWH.

PI_NAMEs: CURRIER, JUDITH S. (contact);ERON, JOSEPH J

PROGRAM_OFFICER_NAME: OJUMU, AKINLOLU O

PROJECT_TERMS: advanced disease;Aging;aging population;aging process;aging related;AIDS clinical trial group;antiretroviral therapy;Biological Markers;Cardiovascular Diseases;Caring;Cell Aging;Chronic;Chronic disability;Chronic Disease;Clinical;cohort;comorbidity;Cross-Sectional Studies;Data;Development;Diabetes Mellitus;Disease;early onset;Enrollment;Event;experience;extend lifespan;Face;follow-up;frailty;Funding;Future;General Population;Geroscience;Growth;healthspan;HIV;HIV Infections;immune function;improved;Infection;Inflammation;insight;interest;Intervention Trial;Life;life span;longitudinal analysis;Measurable;Mediating;novel therapeutics;Observational Study;Older Population;Participant;Persons;Phenotype;phenotypic biomarker;Plasma;potential biomarker;preemptive intervention;Premature aging syndrome;Prevalence;prevent;Process;Research;Resources;Risk Assessment;senescence associated secretory phenotype;senescent cell;Senotherapeutic;Subgroup;success;Therapeutic;therapeutic target;Time;Tissues;Viral;Viral reservoir;Work

PROJECT_TITLE: AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE It is important to study how aging and cellular senescence affect persistence of the HIV reservoir to inform strategies to cure HIV-1 infection. Preliminary observations made by our group suggest that age is a key determinant of reservoir dynamics on long-term ART. In the current proposal, we will leverage a rich repository of stored blood samples and extensive clinical data from the AIDS Clinical Trials Group A5321 cohort, a longitudinal cohort of individuals who have had viremia suppression on ART for an average of 14 years (IQR 12- 17 years), to determine whether the dynamics of the HIV reservoir are associated with age, sex, and levels of cellular senescence markers in blood.

PROJECT_TERMS: Address;Affect;Aftercare;Age;age effect;Age related comorbidities;Aging;aging related;AIDS clinical trial group;antiretroviral therapy;Archives;Binding;Biological Assay;Blood;Blood specimen;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Aging;Cell Count;Cell Cycle Arrest;Cells;Central Nervous System;Clinical;Clinical Data;Clinical Trials;Clonality;Clone Cells;cohort;comorbidity;Complex;cost;curative treatments;Data;detection limit;Development;Disease remission;DNA;Drug Interactions;Exhibits;Female;follow-up;gene therapy;Gut associated lymphoid tissue;high risk;HIV;HIV Infections;HIV-1;human old age (65+);Immunologic Markers;immunosenescence;Immunotherapy;Individual;Infection;Inflammatory;inflammatory milieu;insight;integration site;Interruption;Intervention;intervention effect;Laboratories;latent HIV reservoir;Longitudinal cohort;Longitudinal Studies;lymph nodes;Measurement;Measures;men;observational cohort study;older adult;Older Population;Participant;Pattern;Peripheral Blood Mononuclear Cell;Persons;Phase;phenotypic biomarker;Plasma;Process;Proliferating;Proviruses;Publishing;repository;reproductive tract;Research;Residual state;Risk;RNA;Sampling;senescence;senescence associated secretory phenotype;senescent cell;sex;Site;Stem cell transplant;Time;Tissues;Viral;Viral reservoir;Viremia;Virus;Woman;Work

PROJECT_TITLE: Evaluating the Relationship Between Age and HIV-1 Persistence


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

PHR: Narrative Premature immune aging or immune senescence may be a key contributor to downstream end- organ damage in the setting of HIV and hepatitis virus infections. In this study we will characterize the effect of these chronic viral changes on biomarkers of immune cell aging and try to link these findings to damage to regulatory cells that help control normal immune functions. The effect of HCV cure will be examined.

PROJECT_TERMS: Acceleration;Aging;aging biomarker;aging process;AIDS clinical trial group;antiretroviral therapy;Atherosclerosis;Bacterial Translocation;Biological Markers;Cardiovascular Diseases;CD28 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cells;Chronic;Chronic Hepatitis;Chronic Hepatitis C;chronic infection;Chronic viral hepatitis;Cirrhosis;Clinical;co-infection;cohort;Cohort Studies;comorbidity;Core Protein;Cross-Sectional Studies;Data;design;Development;DNA Methylation;Down-Regulation;Ethnic Origin;Event;exhaustion;Functional disorder;glomerular function;Hepatic;Hepatitis;Hepatitis B Virus;Hepatitis C;Hepatitis C Therapy;HIV;HIV/HCV;Immune;immune activation;immune function;Immunologic Markers;immunosenescence;improved;Individual;Infection;Inflammatory;innovation;Intestinal permeability;Length;Link;Liver Fibrosis;Longitudinal cohort;Macrophage;Measures;Metabolic syndrome;Methods;Methylation;Nature;Neurocognitive;Neurocognitive Deficit;Organ;organ injury;Outcome;Oxidative Stress;Participant;participant enrollment;Pathogenesis;Patients;Persons;premature;Premature aging syndrome;Process;promoter;Race;Regulatory T-Lymphocyte;Reporting;Research;Sampling;senescence;senescent cell;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;telomere;Telomere Shortening;treatment group;treatment response;Viral;Viral hepatitis;Virus Diseases;Work

PROJECT_TITLE: Examining Immune Senescence in PLWH and HCV, utilizing the ACTG BIRTH Cohort samples


PHR: PROJECT NARRATIVE The Molecular Biophysics Training Program provides competitive graduate students at the University of Washington with rigorous training in modern biophysics and application of state-of-the-art physical and quantitative approaches to the studies of molecular and cellular systems with high biomedical relevance. The training program is uniquely positioned in the local biomedical research community by bringing together highly talented graduate students and training faculty from a wide variety of disciplines, such as Biochemistry, Chemistry, Cell Biology, Pharmacology, Microbiology, Physics, and Engineering. This interdisciplinary training experience affords future leaders of academia and industry to broaden their scientific horizons well beyond what they would normally learn in graduate school and prepare them to undertake rigorous and responsible research and commit themselves to pursue a scientific career in research and biomedicine-related areas.

PI_NAMEs: KOLLMAN, JUSTIN M;ZHENG, NING  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Biophysics;Molecular;Training Programs

PROJECT_TITLE: Molecular Biophysics Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE We will conduct the largest study of the health care transition and mental health of adolescents/young adults with mental, behavioral, or developmental disorders in the US to provide new information on how health care transition impacts care quality and outcomes, and how transition can be optimized with targeted health policy.

PI_NAMEs: WISK, LAUREN ELISABETH (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;adolescent mental health;Adult;adverse outcome;Affect;Age;Behavior Disorders;behavioral health;Big Data;care systems;Caring;Characteristics;Child;Childhood;Clinical;critical period;Data;data infrastructure;Data Set;developmental disease;disorder subtype;Disparity;Economically Deprived Population;Eligibility Determination;Equity;ethnic disparity;Evaluation;experience;Exposure to;falls;Goals;Health;health care availability;health care delivery;health care quality;health care service utilization;health equality;Health Expenditures;Health Policy;Health Services Accessibility;Health Status;Health system;Healthcare;Improve Access;improved;improved outcome;Individual;Inequality;innovation;Insulin-Dependent Diabetes Mellitus;Insurance Coverage;Interruption;Intervention;Knowledge;large datasets;Laws;Life Cycle Stages;life span;Link;Longitudinal cohort;Medical;Mental Depression;mental disorder diagnosis;Mental disorders;Mental Health;mental health policy;Mental Health Services;Methodology;multidisciplinary;National Institute of Mental Health;novel;Outcome;parity;Pattern;Personal Satisfaction;Policies;Policy Analysis;Policy Maker;Population;Prevalence;Preventive;Public Health;Quality of Care;Quasi-experiment;racial disparity;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Respondent;response;Retrospective cohort study;Risk;Role;Science;Services;sociodemographic factors;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;Strategic Planning;Subgroup;suicidal;Surveys;Therapeutic;Time;Time Series Analysis;transition to adulthood;treatment comparison;United States;Variant;Visit;Work;young adult;Youth

PROJECT_TITLE: Health care transition utilization and outcomes for youth with mental, behavioral, and developmental disorders

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE The personal, public-health, and economic consequences associated with insufficiently treated opioid use disorder (OUD) are enormous, especially for vulnerable populations who face significant barriers to evidence- based care. While traditional randomized controlled trials (RCTs) have demonstrated the effectiveness of medications for OUD, their limitations in generating evidence that addresses the unique needs of these populations call for the development and application of novel methodologies to improve health economic RCT research designs. The goal of this project is to develop an empirical framework that integrates real-world evidence (RWE) into RCT data analysis using innovative maximum likelihood estimation (MLE) methods to produce more comprehensive, robust, and actionable evidence that can directly inform clinical decision-making and improve patient care for vulnerable individuals affected by the opioid epidemic.

PI_NAMEs: JALALI, ALI  (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Address;Affect;Biometry;Caring;Clinical;clinical decision-making;clinical practice;Clinical Trials;Clinical Trials Network;Communities;comparative;Computerized Medical Record;cost effective;Data;Data Analyses;Data Sources;Development;Drug Approval Processes;econometrics;Economic Burden;economic evaluation;Economics;Effectiveness;effectiveness evaluation;evidence base;Evidence based treatment;flexibility;Food and Drug Administration Drug Approval;Funding;Goals;healing;Health;health data;health economics;Healthcare;Helping to End Addiction Long-term;improved;improved outcome;Individual;innovation;Intervention;Justice;Legal system;Maximum Likelihood Estimate;medication for opioid use disorder;Medicine;Methodology;Methods;National Institute of Drug Abuse;Nature;novel;novel strategies;Opioid;opioid epidemic;opioid use disorder;Patient Care;personal narratives;Population;Populations at Risk;Pregnant Women;prevent;Prevention;Public Health;public health emergency;Randomized, Controlled Trials;Research;Research Design;Resources;Source;Techniques;tool;treatment effect;United States;United States National Institutes of Health;Vulnerable Populations;wasting

PROJECT_TITLE: Novel Econometric Research Designs (NERD) to Help End Addiction Long-term


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of the Rheumatic and Musculoskeletal Disease (RMD) Epidemiology and Outcomes Training Program at the University of North Carolina is to provide state-of-the-art resources and a rich environment to train independent interdisciplinary researchers who will improve our understanding of the magnitude, etiology, impact, and treatment of RMDs, and who will assume leadership roles in RMD epidemiology and outcomes research. The proposed Training Program supports the mission of NIAMS through advancing investigation into the causes, treatment, and prevention of RMDs; training scientists to carry out this research; and dissemination of information about research progress in RMDs. It is responsive to all four cross-cutting scientific themes described in the NIAMS 2020-2024 Strategic Plan (i.e., precision medicine, shared mechanisms of disease, incorporation of patient viewpoints, and involvement of diverse populations) and will help to attract and maintain a robust, diverse, scientific workforce.

PI_NAMEs: CALLAHAN, LEIGH FLEMING (contact);NELSON, AMANDA E

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Epidemiology;Musculoskeletal Diseases;North Carolina;Outcome;Rheumatism;Training Programs;Universities

PROJECT_TITLE: The Rheumatic and Musculoskeletal Disease Epidemiology and Outcomes Training Program at the University of North Carolina

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Millions of people worldwide suffer from neuropathic pain. This proposal aims to validate a new peripheral target for regulating neuropathic pain signaling. Understanding the neural mechanisms that promote persistent pain may lead to the development of much needed, novel drugs and therapies.

PI_NAMEs: BAUTISTA, DIANA MICHELE;LUMPKIN, ELLEN A (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Action Potentials;Address;Afferent Neurons;allodynia;American;Basic Science;Behavior;behavior test;Behavioral;Biological Markers;biomarker validation;Caring;chemotherapy;Chronic;chronic pain;Complex;conditioned place preference;Data;Dependence;design;Development;druggable target;Electrophysiology (science);Emergency Situation;experience;extracellular;Financial Hardship;Functional disorder;Gene Expression;Genes;genetic risk factor;Genetic Variation;Goals;Healthcare Systems;Heterozygote;Human;Hypersensitivity;Individual;Knock-out;Knockout Mice;Mechanics;Mechanoreceptors;Mediating;Mediator;Medical;Modeling;motor behavior;mouse model;Mouse Strains;Mus;Nerve;nerve injury;Nervous System;neuromechanism;neuronal excitability;Neurons;new therapeutic target;Nociceptors;novel therapeutics;Paclitaxel;Pain;pain model;pain signal;painful neuropathy;Peripheral;Peripheral Nervous System Diseases;Persistent pain;Persons;Pilot Projects;Play;Precision therapeutics;predictive marker;Predisposition;Preparation;prevent;Proteins;Research;Rest;Role;SCN1A protein;Sensory;sensory system;Skin;somatosensory;spared nerve;Susceptibility Gene;Symptoms;Tactile;Testing;therapeutic biomarker;therapeutic target;Time;Touch sensation;trafficking;Transcript;voltage

PROJECT_TITLE: Role of Scn1b in Susceptibility to Neuropathic Pain


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PHR: NARRATIVE This highly successful alcohol research training program will allow trainees to gain the knowledge and skills needed to (1) research the etiology of alcohol misuse and alcohol use disorder, involving both animal and human research studies, and (2) develop effective assessment, prevention and intervention approaches for alcohol use disorders. Trainees are explicitly trained in integrating diverse research methodologies and perspectives to address the complex and costly public health problems posed by alcohol misuse and alcohol use disorder.

PI_NAMEs: LARIMER, MARY E. (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: alcohol research;Psychology;Training

PROJECT_TITLE: Psychology Training in Alcohol Research (PTAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (32)]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

PHR: Narrative This grant is designed to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of drug and substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. The objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in drug abuse. These scientists will have the skills to continue to study and work towards solving drug use disorders thereby supporting the mission of NIDA.

PI_NAMEs: TRAYNOR, JOHN R. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TITLE: Postdoctoral Training in the Biology of Drug Abuse

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Surgical pain is a major clinical problem requiring new non-opioid treatment strategies. Here we will develop a peptidomimetic targeting NF-κB essential modulator (IKGKB, UniProt #Q9Y6K9) and test whether a peptide binding NF-κB essential modulator limits surgical pain in young and old rodents. This proposal can provide a non-opioid drug to treat surgical pain while also more broadly uncovering how NF-κB essential modulator contributes to inflammatory pain.

PI_NAMEs: GROSS, ERIC RICHARD (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: age related changes;Aging;Alanine;allodynia;Amino Acids;Artificial Intelligence;Automobile Driving;Binding;Biological;Biological Assay;Biological Testing;C57BL/6 Mouse;Cell Aging;cell injury;Cell Line;Clinical;cohort;Complex;cytokine;Dependence;Digestion;Dose;Drug Interactions;drug metabolism;Edema;Elderly;Enzyme-Linked Immunosorbent Assay;experimental study;Fibroblasts;Genes;Goals;Hair;hallmarks of aging;Health;High Pressure Liquid Chromatography;Hour;improved;Inflammation;Inflammatory;inflammatory pain;Inflammatory Response;Injury;Interleukin-1 beta;Interleukin-6;Laboratories;Luciferases;luminescence;Measurement;Measures;mechanical allodynia;Mediating;Methods;Modeling;Modification;Molecular;Molecular Target;Motion;Mus;NIH 3T3 Cells;non-opioid analgesic;older adult;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;Overdose;Pain;Pain Measurement;pain model;Pathway interactions;Peptide Hydrolases;Peptide Synthesis;Peptides;peptidomimetics;Persons;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Play;Polypharmacy;Population;Production;protein aminoacid sequence;protein protein interaction;Proteins;receptor;Reporter;Research;Rodent;Role;Scanning;Secondary to;senescence associated secretory phenotype;sex;Site;skills;Skin;Structure;Surgical incisions;surgical pain;Techniques;Testing;Therapeutic;tissue injury;Tissues;TNF gene;treatment strategy;United States;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Binding NF-κB essential modulator (NEMO) to Treat Surgical Pain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: NARRATIVE Progressive pulmonary fibrosis (PF) denotes a group of related diseases that slowly replace the gas exchanging units of the lungs with scar tissue, often resulting in respiratory failure and death. This Program will leverage a large and ongoing study of at-risk relatives of patients with Familial PF to develop a new level of understanding of the earliest stages of disease, prior to the onset of symptoms. Our goals are to discover critical mechanisms that underlie pre-clinical PF and to identify new targets that can be used in future studies aimed at preventing progressive PF.

PI_NAMEs: BLACKWELL, TIMOTHY S. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: airway epithelium;alveolar epithelium;Atlases;Automobile Driving;Biological;Biological Markers;Biopsy;Blood;Bronchoalveolar Lavage;cell type;Cells;Cessation of life;Chemicals;Cicatrix;Clinical;cohort;Cohort Studies;Data;data acquisition;Development;Disease;disease model;Disease Progression;disorder prevention;Distal;Early identification;Environment;Environmental Exposure;Epigenetic age;Epigenetic Process;epithelial injury;epithelial repair;Epithelium;Etiology;Evaluation;Event;Functional disorder;functional genomics;Future;Gases;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic Transcription;Genetic Variation;Genomics;Goals;human subject;Image;improved;In Situ;Injury;insight;interstitial;Intervention;Knowledge;Length;Lung;Measures;Mediating;Metabolic;Metals;Modeling;Molecular;Morbidity - disease rate;mortality;Motion;multiple omics;Natural History;Nature;novel;novel strategies;Organoids;Pathogenesis;Patients;Phenotype;pre-clinical;prevent;Prevention;programs;Pulmonary Fibrosis;Quantitative Trait Loci;Relative Risks;repaired;Respiratory Failure;response;response to injury;Risk;risk stratification;risk variant;Services;Shapes;Standardization;Stimulus;Symptoms;Technology;telomere;Testing;Therapeutic;Time;Tissues;Toxic Environmental Substances;transcriptomic profiling;transcriptomics;treatment strategy;Work

PROJECT_TITLE: Disease Mechanisms of Early Pulmonary Fibrosis

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP (JA)]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

PHR: PROJECT NARRATIVE As per the instructions included in PAR-21-088, this narrative does not need to be completed for this component. Please see Project Narrative for the entire Project in the Overall Component.

PROJECT_TERMS: Academic Medical Centers;Area;Budgets;Characteristics;Charge;Communication;Consensus;cost;cost efficient;Cost Savings;Databases;Disease;Environment;Equilibrium;flexibility;Funding;Goals;Grant;Human Resources;Instruction;Interdisciplinary Study;Leadership;Light;Maintenance;meetings;Mind;Mission;Monitor;operation;Productivity;programs;Pulmonary Fibrosis;Research Personnel;Resources;Schedule;skills;Structure;translational genomics;United States National Institutes of Health;Vision;willingness;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: SALISBURY, MARGARET LOUISE (contact)

PROJECT_TERMS: Academic Medical Centers;Adverse event;Age;airway epithelium;Biological;Biological Markers;Biopsy;Blood Donations;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Bronchoscopy with Bronchoalveolar Lavage;Case Report Form;Catalogs;Cells;Chest;Child;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Collecting Cell;Collection;Cryopreservation;Data;data sharing;Databases;Disease;distributed data;Documentation;Eligibility Determination;eligible participant;Enrollment;Ensure;Environment;Environmental Exposure;Epithelial Cells;experience;Family;Genomics;Goals;Human;Human Resources;human subject;Human Subject Research;Individual;Industry;Instruction;interstitial;Lung;Maintenance;Manuals;Measures;member;Monitor;Motion;Observational Study;Participant;Pathogenesis;Patient Recruitments;Patients;Persons;Populations at Risk;pre-clinical;prevent;Procedures;Process;programs;prospective;Prospective cohort;Protocols documentation;Pulmonary Fibrosis;Pulmonary function tests;Questionnaires;recruit;Registries;Research;research clinical testing;Research Personnel;Resolution;Resources;Risk;Safety;Sampling;screening;Siblings;Specimen;Structure of parenchyma of lung;Therapeutic Intervention;Time;transcriptomics;Vertebral column;volunteer;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Prevention;Pulmonary Fibrosis

PI_NAMEs: BANOVICH, NICHOLAS ELI (contact)

PROJECT_TERMS: Address;Biological Assay;Biology;Cells;Code;Collaborations;Communities;Computer Analysis;computerized data processing;Data;data dissemination;data modalities;data repository;data sharing;Data Storage and Retrieval;database of Genotypes and Phenotypes;Development;Disease;disorder risk;Ensure;Environmental Risk Factor;epigenomics;Gene Expression;Generations;Genetic;genetic risk factor;Genomic approach;genomic data;Genomics;Goals;Incidence;Institution;Instruction;Laboratory Personnel;Lung;Maps;Mediating;Methods;Molecular;Multiomic Data;multiple omics;Pathogenesis;Performance;Play;Preparation;Procedures;programs;progression risk;Pulmonary Fibrosis;Quality Control;Research;Risk Factors;RNA;Role;Sampling;Secure;Sequence Read Archive;single cell analysis;single nucleus RNA-sequencing;System;Technology;Training;transcriptome sequencing;transcriptomics;transmission process;XCL1 gene

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis

PROJECT_TERMS: Address;Affect;Age;Age Years;Automobile Driving;B-Lymphocyte Subsets;Biological;Biological Markers;Biopsy;Blood;Bronchoalveolar Lavage;Bronchoscopy;Categories;CD14 gene;Cells;Characteristics;Chronology;Clinical;clinical development;clinical diagnosis;cohort;Cohort Studies;Cytokine Signaling;Data;data integration;Development;Disease;Disease Progression;DNA Methylation;Enrollment;Epigenetic age;Epigenetic Process;First Degree Relative;follow-up;Frequencies;Gene Expression Profile;General Population;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genotype;Growth Factor;High Resolution Computed Tomography;Image;Immune;improved;Individual;Instruction;interstitial;kindred;Knowledge;Length;Lung;Lymphocyte;Measures;methylation pattern;monocyte;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Population;pre-clinical;preclinical study;predictive marker;predictive modeling;Predictive Value;Prevalence;programs;Pulmonary Fibrosis;radiological imaging;Research;Risk;risk variant;Scanning;screening;Signal Pathway;single-cell RNA sequencing;Specificity;T-Lymphocyte;telomere;Testing;transcriptomic profiling;transcriptomics;X-Ray Computed Tomography

PROJECT_TITLE: Project 1: Mechanisms of Early Disease Progression in FPF


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis

PI_NAMEs: KROPSKI, JONATHAN ANDREW (contact)

PROJECT_TERMS: activating transcription factor 3;airway epithelium;Alveolar;alveolar epithelium;Appearance;Binding;Biopsy;Biopsy Specimen;Cell Nucleus;cell type;Cells;cellular pathology;Chromatin;cohort;comparison control;Data;Data Analyses;Development;differential expression;Disease;Distal;Epithelial Cells;epithelial injury;epithelial repair;epithelial stem cell;Epithelium;ETS2 gene;Evolution;Exhibits;Experimental Models;follow-up;FOSB gene;Freezing;Frequencies;Functional disorder;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Risk;Genetic Transcription;genetic variant;Genetic Variation;Genotype;High Resolution Computed Tomography;injury and repair;Instruction;interstitial;JUNB gene;Link;Lung;Lung Diseases;Macrophage;Mediating;Modeling;Molecular;monocyte;Mucous body substance;multiple omics;Natural regeneration;Nucleic Acid Regulatory Sequences;Organoids;Outcome;Pathogenesis;Patients;Phase;Pilot Projects;Positioning Attribute;pre-clinical;programs;Pulmonary Fibrosis;Quantitative Trait Loci;recruit;repaired;response to injury;Risk;risk variant;RNA;Role;Secretory Cell;Severities;single-cell RNA sequencing;Stress;Testing;transcription factor;Transcriptional Regulation;transcriptomics;X-Ray Computed Tomography;XCL1 gene

PROJECT_TITLE: Project 3: Functional Genomic Mechanisms of Epithelial Dysfunction in Pulmonary Fibrosis


PROJECT_TERMS: Affect;Alveolar;Anatomy;Area;Atlases;Automobile Driving;Biology;Biopsy Specimen;Cell Nucleus;cell type;Cells;Cellular Assay;Cellular biology;cohort;Communication;Complex;Cross-Sectional Studies;Data;Detection;Development;Disease;Disease Progression;Distal;Endothelium;Event;Evolution;experimental study;Fibroblasts;Formalin;Gene Expression;Genes;genetic architecture;Genetic Transcription;Genomics;Histologic;Homeostasis;Image;In Situ;Individual;insight;Instruction;Interruption;interstitial;Link;Lung;Machine Learning;Mediating;Microspheres;Modeling;Molecular;Molecular Analysis;molecular pathology;Molecular Profiling;Multiomic Data;Natural History;Nature;Neighborhoods;novel;novel therapeutics;Outcome;Paraffin Embedding;Participant;Pathogenesis;Patients;Phase;Positioning Attribute;pre-clinical;preservation;programs;promote resilience;Pulmonary Fibrosis;radiological imaging;Radiology Specialty;Regional Anatomy;Resolution;Risk;Sampling;Series;Signal Transduction;single-cell RNA sequencing;Slice;spatial integration;Structure;Structure of parenchyma of lung;System;Technology;Therapeutic;Tissue Embedding;Tissue Sample;Tissues;transcriptomics;Work

PROJECT_TITLE: Project 4:  Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Pulmonary Fibrosis

PROJECT_TERMS: absorption;Adult;advanced disease;Aerosols;Age;Air Pollutants;Biological;Biological Markers;Blood;Carbon Black;Characteristics;Chemicals;chest computed tomography;Chronic;cigarette smoke;Clinical;clinical development;Coal;coarse particles;cohort;Data;Development;Diagnosis;Disease;disease natural history;Dust;Enrollment;Environmental Exposure;environmental intervention;Epithelium;experience;Exposure to;Family;fine particles;follow-up;Gene Expression;Goals;Health;Heavy Metals;Immune response;improved;Individual;Injury;Instruction;interstitial;Intervention;Lead;Life Expectancy;life span;Link;Logistic Regressions;Lung;Lung Diseases;lung imaging;Mass Spectrum Analysis;Measurement;Measures;Mediation;Metabolic;metabolomics;Metals;middle age;Modality;Modeling;Molds;National Institute of Environmental Health Sciences;Natural History;Nested Case-Control Study;novel;Occupational;older adult;Onset of illness;Optics;Participant;Pathogenesis;Pathway interactions;Patient Self-Report;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Population;Populations at Risk;pre-clinical;preclinical study;Predisposition;prevent;Process;programs;prospective;Pulmonary Fibrosis;Recording of previous events;Recurrence;repaired;Reporting;residence;Resolution;response;Risk;Risk Factors;Sampling;screening;Seasons;Serum;sex;Silicones;single-cell RNA sequencing;Smelts;Structure of parenchyma of lung;Sulfate;Testing;transcriptomics;Urine;wearable device;Welding;Wrist;X-Ray Computed Tomography

PROJECT_TITLE: Project 2: Environmental exposures in pre-clinical FPF


NIH_SPENDING_CATS: Cancer

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: NARRATIVE We propose the development of the Surgical Oncology Research Training at Indiana (SORTI) program to develop the next generation of surgical oncology-focused scientists. The SORTI program is anchored by our successful history of two-year dedicated research training by (1) a highly accomplished team of researchers and clinicians to provide tailored mentoring for the trainees and (2) the unique 15-year partnership in training surgical research trainees in conjunction with the American College of Surgeons’ Cancer Programs. The SORTI program will be a national leader in increasing the pipeline of qualified surgical oncology physician-scientists who go on to faculty positions, with independently funded research agendas, making seminal contributions to the field, and mentoring their own trainees, while also delivering high-quality, compassionate care to cancer patients.

PI_NAMEs: BILIMORIA, KARL Y (contact);NAKSHATRI, HARIKRISHNA

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The Iowa Neuroscience Training Program emphasizes a highly interdisciplinary orientation, tied to the Jointly Sponsored Predoctoral Training Program in the Neurosciences’ mission to foster work toward the diagnosis, treatment, and prevention of nervous system disorders, and the basic sciences fundamental to this purpose. Our Program remains committed to training a diverse, quantitatively literate, and highly expert workforce of neuroscientists who will go into leadership roles related to the Nation’s biomedical and behavioral research agendas. The Program’s interdisciplinary training produces neuroscientists who are conversant across the many disciplines that comprise contemporary neuroscience.

PI_NAMEs: BAKER, SHEILA A;TRANEL, DANIEL T. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Neuroscience Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

PHR: PROJECT NARRATIVE Research into the causes of SUD has led to the identification of multiple factors that contribute to vulnerability and the hope for better treatments in the future. For this to continue we need to actively train the next generation of addiction researchers in multidisciplinary, translational approaches such that treatments can move forward from the bench to the clinic. The aim of this T32 is to provide these opportunities to postdoctoral researchers who plan to have a career in SUD research.

PI_NAMEs: MCCLUNG, COLLEEN A (contact);TORREGROSSA, MARY M

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TITLE: Supportive, Multidisciplinary Addiction Research Training (SMART)


PHR: PROJECT NARRATIVE  This program proposes an integrated, effective training plan to generate a diverse community of scientists who can work effectively across traditional divides in chemistry and biology to solve important biomedical problems.

PI_NAMEs: KOUTMOU, KRISTIN S (contact);SCOTT, EMILY E

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Michigan Chemistry-Biology Interface Training Program


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE The Biotechnology Training Program at Northwestern University supports a series of core activities for training a diverse group of students, nucleates the biotechnology community, and provides numerous training opportunities. The program addresses the interdisciplinary and rapidly changing nature of biotechnology training through coursework, research, experiential learning, industrial internships, seminars and other opportunities that broaden students’ training in and understanding of modern biotechnology. Innovative and unique training activities supported by the Program include events such as the Biotechnology Seminar Series, Biotechnology Practicum, Biotech Nexus, and many Professional Development Opportunities customized to promote diverse paths in biotechnology.

PI_NAMEs: LEONARD, JOSHUA NATHANIEL (contact)

PROJECT_TITLE: Biotechnology Predoctoral Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The overall goal of this project is to establish a premier CaREER (Cancer Research Education Excellence in Radiotherapy) program to train a highly diverse next generation of scientists, technologists and physicians who will be empowered to pursue careers involving research in emerging and transformative areas of radiotherapy. These transformative areas of research have major potential to address radiotherapy limitations in substantial ways, extend radiotherapy to curative treatment of both local and metastatic disease, and reduce disparities with innovations to reduce treatment time and cost, enhance patient convenience, and significantly increase survival and quality of life for cancer patients.

PI_NAMEs: LAIHO, MARIKKI  (contact);VISWANATHAN, AKILA

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Artificial Intelligence;Awareness;Biocompatible Materials;Cancer Patient;cancer radiation therapy;cancer therapy;career;Career Choice;career development;Caring;Collaborations;Communication;community organizations;Comprehensive Cancer Center;cost;Critical Thinking;Cultural Backgrounds;curative treatments;design;disease disparity;Disparity;disparity reduction;Dose Rate;Education;education research;Educational workshop;empowerment;Environment;experience;Faculty;global health;Goals;graduate student;hands on research;higher education;Historically Black Colleges and Universities;Industry;Infrastructure;innovation;Institution;Knowledge;Leadership;Magnetic Resonance Imaging;Malignant Neoplasms;Medicine;Mentors;new technology;next generation;Normal tissue morphology;novel strategies;Oncology;Oral;Outcome;outreach;Participant;Patients;Peer Review;Physicians;posters;Process;programs;Publications;Publishing;Quality of life;Radiation Oncology;Radiation therapy;Radioimmunotherapy;Radiotherapy Research;recruit;Research;Research Design;Research Personnel;Research Project Grants;responsible research conduct;Science;Scientist;skills;student participation;symposium;Technology;technology development;Time;tool;Toxic effect;Training;Treatment Cost;tumor;Underrepresented Minority;underserved area;Universities;virtual platform;Work

PROJECT_TITLE: CaREER: Cancer Research Education Excellence in Radiotherapy


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: PROJECT NARRATIVE Black women living with HIV (BWLWH; 40% unsuppressed) in Miami, FL (a southern HIV epicenter) and in the U.S. in general, need effective interventions to improve viral suppression. Unique and intersectional adversities (e.g., trauma, discrimination, stigma, gender-related stressors) faced by BWLWH are associated with mental health symptoms, medication nonadherence, and viral non-suppression, however there is no existing effective adherence intervention explicitly addressing their impact. The proposed randomized control trial (a) will assess the efficacy of Striving Towards EmPowerment and Medication Adherence (STEP-AD) in increasing viral suppression (via medication adherence), (b) is built on a successful NIMH funded K23 that provided strong preliminary evidence of acceptability, feasibility, and efficacy among BWLWH, and (c) may equip us with an evidence-based adherence intervention to improve viral suppression among BWLWH, a U.S. National HIV/AIDS Strategy designated priority population.

PI_NAMEs: DALE, SANNISHA K. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adherence;Adverse event;Anti-Retroviral Agents;antiretroviral therapy;biopsychosocial;black women;Body Image;Caring;Case Series;CD4 Lymphocyte Count;Clinic;Cognitive Therapy;Communicable Diseases;Communities;community partners;comparison control;Control Groups;coping;Coping Skills;Data;deprivation;Diagnosis;Discrimination;Disproportionately impacts women;effective intervention;efficacious intervention;efficacy evaluation;empowerment;Epidemic;evidence base;Exclusion;experience;Face;Failure;Feeling;Female;Florida;Funding;Future;Gender;Gender Role;Goals;Health behavior;health disparity populations;HIV;HIV/AIDS;improved;Individual;Institution;intersectionality;Intervention;Link;Literature;Mediating;Mediator;medication compliance;medication nonadherence;Mental Depression;Mental Health;microaggression;minority stress;Modeling;mortality;National Institute of Mental Health;Neighborhoods;Persons;pilot test;Population;post intervention;Post-Traumatic Stress Disorders;promote resilience;racism;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;Research Support;resilience;Sampling;secondary outcome;Sexism;social stigma;stressor;success;Symptoms;System;Techniques;theories;therapy adherence;therapy development;Thinking;Time;Trauma;trauma symptom;treatment as usual;United Nations;United States National Institutes of Health;Universities;Violence;Viral;Viral Load result;White Women;Woman;Work

PROJECT_TITLE: A Randomized Control Trial of Striving Towards EmPowerment and Medication Adherence (STEP-AD) among Black Women Living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-S (03)]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Quantitative sensory testing (QST) and brain neuroimaging can both give important mechanistic insight into chronic pain, but they could be improved by a technique that can stimulate nociceptors in isolation. Our lab has developed a procedure for nociceptive-specific heating (NoSH) stimulation with no interference from innocuous warm fibers. Nociceptive sensitivity will be measured in patients with fibromyalgia, a nociplastic pain condition, and compared with data from pain-free controls, which may constitute a novel biomarker for use in other mechanistic studies and clinical trials.

PI_NAMEs: HARPER, DANIEL ELLIOTT (contact)

PROJECT_TERMS: analog;Area;Biological Markers;Brain;chronic pain;Clinical;Clinical Trials;Communities;Computer software;computerized;Data;Development;Devices;Enrollment;experience;Fiber;Fibromyalgia;fibromyalgia patients;Functional Magnetic Resonance Imaging;heat stimulus;Heating;Human;human old age (65+);improved;Individual;insight;instrument;Measurable;Measures;Methods;Modality;Modeling;neuroimaging;Nociception;Nociceptors;novel;novel marker;Pain;Pain Free;pain processing;patient subsets;Patients;pressure;Procedures;programs;Psychophysics;response;Sensory;Skin;Somatosensory Receptor;Stimulus;success;Techniques;Testing;Visual

PROJECT_TITLE: Psychophysical distillation of pure pain by nociceptive-specific heating


NIH_SPENDING_CATS: Aging

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The major mission of this T32 is to train dedicated, motivated, and well-qualified predoctoral and postdoctoral fellows in aging biology and translational gerontology research. Given the projected increase in the number of older adults living in the US by 2050, it is critical that significant advances be made toward understanding the biology of aging and related diseases, and that these findings translate into enhanced care of older patients. The present T32 Program will provide state-of-the-art training in aging biology research to talented scientists, preparing them for academic careers at institutions throughout the country and equipping them to make novel contributions toward understanding the biology and enhancing management of disabling diseases of aging.

PI_NAMEs: ANDERSON, ROZALYN M.;ASTHANA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: age-related disease;aging related;Biology of Aging

PROJECT_TITLE: Biology of Aging and Age-Related Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative The Vision Science Graduate Group on the UC Berkeley campus is engaged in training predoctoral and postdoctoral trainees from a broad range of backgrounds to generate new knowledge about the eye and visual system in health and disease - from the basic mechanisms of vision through translation and application of new therapies to people with vision disorders.

PI_NAMEs: ROORDA, AUSTIN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Training Program in Vision Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: KINSHASA

ORG_COUNTRY: CONGO DEM REP

ORG_FIPS: CG

ORG_NAME: KINSHASA SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Zoonotic diseases like Monkeypox and Ebola virus disease are a significant public health threat in Democratic Republic of the Congo (DRC) and have a high risk of international exportation. This project aims to improve the ability of DRC to respond to zoonotic diseases by developing rigorous surveillance systems, investigating medical countermeasures and clinical treatments, identifying key risk factors in primary transmission of disease, and creating a resilient interdisciplinary public health workforce.

PI_NAMEs: KABA, DIDINE KINKODI (contact)

PROJECT_TITLE: RFA-CK-22-001, Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC) - 2022


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Lupus Midwest Network (LUMEN) will improve our understanding of how kidney disease and antiphospholipid syndrome (a condition leading to recurrent blood clots) impact life expectancy, hospitalizations, healthcare utilization, and development of cardiovascular disease, infections, and osteoporosis in persons with systemic lupus. This work will inform interventions to optimize patient care, prevent or reduce poor outcomes in patients with lupus, and will identify a window of opportunity in persons with cutaneous lupus to prevent the transition to systemic lupus.

PI_NAMEs: CROWSON, CYNTHIA S (contact)

PROJECT_TITLE: DP22-002 Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts - 2022


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed application will extend longitudinal follow-up of the California Lupus Epidemiology Study (CLUES) cohort, which is designed to advance our understanding of the natural history, biology, treatment and outcomes of systemic lupus erythematosus (SLE) among a racially/ethnically diverse population. Two special projects are proposed to investigative the metabolome during and after flare and the natural history of disability.

PI_NAMEs: DALL'ERA, MARIA  (contact);YAZDANY, JINOOS

PROJECT_TITLE: DP22-002 Racial/ethnic and socioeconomic disparities in biologic and clinical SLE outcomes


PHR: PROJECT NARRATIVE (Relevance) Lupus is a complex autoimmune disease that disproportionately afflicts women, particularly from minority groups. Significant racial health disparities remain and may be getting worse. Investigation into areas that will reduce these disparities is important for our population’s health and will inform us about how best to treat everyone with this condition.

PI_NAMEs: LIM, SUNG SAM (contact)

PROJECT_TITLE: DP22-002 Georgians Organized Against Lupus: The GOAL of Better Understanding Social Determinants of Health in Lupus


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECTIVE NARRATIVE Systemic Lupus Erythematosus is a life long autoimmune condition which can be life-threatening. Up to 20% of all Lupus patients are children diagnosed prior to 18 years of age. This study will utilize a large cohort of pediatric Lupus patients in a long-term United States registry to understand the disease, best treatments and what factors influences important outcomes important to both patients and providers.

PI_NAMEs: HERSH, AIMEE O (contact);KNIGHT, ANDREA ;SON, MARY BETH F.


ORG_CITY: NEW HAVEN

ORG_NAME: CONNECTICUT AGRICULTURAL EXPERIMENT STA

ORG_STATE: CT

PHR: Project Narrative-Williams RFA-CK-22-004 Cases of tick-borne diseases continue to both increase and pose a threat to public health across the United States largely due to range expansion of native and invasive tick species. An integrated tick management strategy that includes the oral delivery of acaricides for systemic treatment of the major reproductive host (white-tailed deer) and major pathogen reservoirs (small rodents) has significant potential to be highly effective in suppression of host-seeking abundances of infected ticks over large areas. Acaricide-laced bait could eventually be commercialized and willingly distributed by homeowners or vector control professionals as millions of Americans currently spend billions of dollars annually feeding wildlife for their own enjoyment.

PI_NAMEs: WILLIAMS, SCOTT C. (contact)

PROJECT_TITLE: Suppression of Host-Seeking Ixodes scapularis Abundances and Interruption of Pathogen Transmission Through Orally Delivered Systemic Acaricide Treatment of White-tailed Deer and Peromyscus spp.


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE. HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health Lupus remains a leading cause of death in young women, with racial/ethnic minority patients having worse long-term outcomes, including progression to end stage renal disease and overall mortality, and worse intermediate outcomes of disease activity, damage accrual, and quality of life. This proposal leverages our well-established, longitudinal, ethnically/racially and socioeconomically diverse, and phenotypically well-characterized cohort of 900+ patients with lupus to better understand the epidemiology of disease. The overarching goals include clarification of the long-term natural history of SLE by evaluating disease severity, morbidity, and multi-morbidity; assessment of disparities in illness experience associated with race/ethnicity, age, and socioeconomic status; novel collection of genetic biospecimens to identify targets to improve lupus care; and evaluating an innovative strategy to identify early kidney disease in high-risk patients.

PI_NAMEs: BUYON, JILL P;GOLD, HEATHER TAFFET;IZMIRLY, PETER  (contact)

PROJECT_TITLE: DP22-002 HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: Narrative Drug resistant TB strains are still able to successfully transmit despite the fitness cost associated with these resistance causing mutation. Elucidating how the transcriptome of rifampicin resistant mutants with or without compensatory mutations evolves within an in vitro and in vivo environment. Understanding whether different rifampicin mutations with or without a compensatory mutation effects the bacilli’s susceptibility to second-line anti-TB drugs and whether these mutants more rapidly acquirer drug additional resistance, will allow us to inform TB control programs on patient management.

PI_NAMEs: STREICHER, ELIZABETH MARIA (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: acquired drug resistance;Address;Affect;Amino Acids;Bacillus;Bacteria;bacterial fitness;biological adaptation to stress;Biological Assay;clinically relevant;Compensation;Complex;cost;Data;Disease Outbreaks;DNA-Directed RNA Polymerase;driving force;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Engineering;Ensure;Environment;Epidemic;Event;Evolution;Exposure to;fitness;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Goals;Growth;in silico;In Vitro;in vivo;Infection;Infectious Diseases Research;insight;Knowledge;Macrophage;Maps;Modeling;Multi-Drug Resistance;mutant;Mutate;Mutation;Mycobacterium tuberculosis;next generation;pathogen;Pathogenicity;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Point Mutation;Population;Predisposition;progenitor;programs;promoter;Regulator Genes;Reporting;Research;Resistance;resistant strain;Resolution;response;Rifampicin resistance;Rifampin;Sigma Factor;Signal Transduction;Stress;stressor;Technology;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Treatment outcome;Tuberculosis;tuberculosis drugs;Universities

PROJECT_TITLE: Adaptation, fitness and resistance in rifampicin-resistant M. tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Organ Transplantation;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: No other imaging modality can non-invasively visualize the subcellular biochemistry revealed by 2-photon imaging (2PI). 2PI will be an important clinical assessment tool for genetic, molecular and tissue transplantation therapies that restore cellular function. I want to use 2PI to investigate the biochemistry of live host and transplanted retinal tissues because understanding in vivo changes in the biochemistry is crucial for establishing objective endpoints for novel treatments that target advanced retinal degeneration.

PI_NAMEs: BROWNE, ANDREW W (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Age;Age related macular degeneration;Animal Model;Award;Biochemical;Biochemistry;Biological Markers;Biological Sciences;Biology;biomarker identification;Biophotonics;Bioreactors;blind;Blindness;California;Capital;career;career development;Cell Death;Cell Physiology;cell replacement therapy;cell type;Cells;Cellular biology;Cessation of life;Chemistry;Clinical;Clinical Assessment Tool;Collaborations;Data;Development;Development Plans;Disease;doctoral student;Elderly;Electrophysiology (science);Elements;engineered stem cells;Engineering;Ensure;Equipment;Exhibits;experience;Eye;Eye diseases;Fluorescence;Fluorescence Microscopy;Fostering;Functional disorder;Functional Imaging;Future;Gene Mutation;Genetic;Genetic Diseases;Goals;High Pressure Liquid Chromatography;Histology;Human;IACUC;Image;imaging biomarker;Imaging Device;imaging modality;Imaging Techniques;Immunohistochemistry;improved;In Vitro;in vivo;Inflammation;insight;invention;Investigation;Knowledge;Label;Laboratories;Laboratory Research;Light;Link;Mentors;Metabolic;metabolic imaging;Metabolism;Methods;Microfluidics;Microscope;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Monitor;mouse model;Multimodal Imaging;Mus;Mutation;next generation;non-invasive imaging;novel;novel therapeutics;Operative Surgical Procedures;optical imaging;Optics;organoid transplantation;Organoids;Phase;Photoreceptors;Physicians;Population;pre-clinical research;preclinical study;preclinical trial;predictive marker;Procedures;professor;Protocols documentation;Quality Control;Rattus;Recovery;Rehabilitation therapy;Replacement Therapy;replacement tissue;Reporter;Reporter Genes;Research;Research Activity;Research Personnel;Resources;restoration;Retina;retina transplantation;Retinal Degeneration;Retinal Diseases;retinal imaging;Retinoids;Scientist;single-cell RNA sequencing;skills;Source;stem cells;Structure of retinal pigment epithelium;success;superior colliculus Corpora quadrigemina;System;Techniques;Testing;Therapeutic;therapeutic candidate;Time;tissue culture;Tissue Transplantation;Tissues;tool;Training;Training Programs;Training Support;transcriptomics;Transgenic Organisms;Translating;Translational Research;Translations;Transplantation;transplantation therapy;treatment response;two-photon;Universities;Vision;Visual;Visualization;Work

PROJECT_TITLE: In vivo 2-photon imaging of retinal biochemistry before and after retinal organoid transplantation


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Clinically, we lack ways of identifying adults at high risk of adverse outcomes after a first venous thromboembolism, which is a blood clot in the veins including pulmonary embolism and deep vein thrombosis. Adults who have experienced a venous thromboembolism may be at high risk for patient-relevant symptoms, a second venous thromboembolism, and death. In this study, we will characterize adverse outcomes in the 12 months after a first venous thromboembolism and will evaluate whether 3 biomarkers and 2 modifiable risk factors (anticoagulant type and physical activity) are associated with these outcomes.

PI_NAMEs: HARRINGTON, LAURA BRIENNE (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Accelerometer;Acute;Adult;adverse outcome;Age;American;American Heart Association;antagonist;Anticoagulants;Anticoagulation;Area;Attention;biobank;Biological Markers;Blood;Blood coagulation;Brain natriuretic peptide;Cardiovascular system;Cessation of life;Chronic;Clinical;cohort;Cohort Studies;Collection;common symptom;Consent;Data;Data Collection;Deep Vein Thrombosis;Development;Dimensions;Dyspnea;Electronic Health Record;Eligibility Determination;Enrollment;epidemiology study;Etiology;Event;experience;Fibrin fragment D;follow-up;functional status;Future;Heart Rate;Hemostatic function;high risk;high risk population;Impairment;improved;Individual;insight;Integrated Delivery of Health Care;interest;International;Intervention;Joints;Knowledge;Measurable;Measurement;Measures;member;Mental Health;Methods;modifiable risk;novel;Oral;Outcome;Pain;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Physical activity;physical conditioning;Population;population based;Population Study;post intervention;Postphlebitic Syndrome;Prevalence;prevent;Prognosis;programs;prospective;Pulmonary Embolism;Quality of life;recruit;Recurrence;Rehabilitation therapy;Research;Research Personnel;Research Support;Rest;Risk;Risk Factors;Risk Reduction;Shortness of Breath;Societies;Specific qualifier value;Surveys;Swelling;Symptoms;System;Thrombosis;Time;Troponin;Veins;venous thromboembolism;Virulence Factors;Vitamin K;Washington;Wrist

PROJECT_TITLE: Venous Thromboembolism Sequelae in a Population-based Inception Cohort

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative As organisms age they lose the ability to maintain proper levels of viable proteins, a function termed proteostasis. We have shown that ultradian, 12-hour rhythms of nuclear speckle liquid-liquid phase separation (LLPS) dynamics are essential for proteostasis, and that these LLPS dynamics change during cellular senescence. We aim to establish changes to nuclear speckle LLPS dynamics as hallmarks of senescence and aging, and to demonstrate that these changes can be reversed genetically and pharmacologically.

PI_NAMEs: DION, WILLIAM AARON (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;age related;aged;Aging;Caenorhabditis elegans;Cell Aging;Cell Cycle;cell injury;Cell model;Cells;ChIP-seq;Chromatin;Chronology;confocal imaging;Core Protein;Couples;Data;Defect;Diffuse;druggable target;Embryo;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Environment;Evolution;Exhibits;extend lifespan;Fibroblasts;fluidity;Fluorescence Recovery After Photobleaching;Gene Expression;Genes;Genetic;Genetic Transcription;hallmarks of aging;Health;Homeostasis;Hour;improved;In Vitro;in vivo;Inflammatory;Knowledge;life span;Link;Liquid substance;Liver;Mammalian Cell;Membrane;Methods;misfolded protein;model organism;Modeling;Molecular;Morphology;Mus;mutant;N-terminal;Normal Cell;novel;Nuclear;Organelles;Organism;Orthologous Gene;pharmacologic;Phase;Physical condensation;Physiological Processes;Probability;Process;protein aggregation;protein folding;Proteins;Proteome;proteostasis;proteostasis loss;Rejuvenation;Resistance;response;Role;Scaffolding Protein;senescence;senescent cell;Signal Transduction;Son;SRSF2 gene;System;Tamoxifen;Telomere Shortening;Testing;Time;Tissues;transcriptome sequencing;XBP1 gene

PROJECT_TITLE: Nuclear speckle liquid-liquid phase separation dynamics in senescence and aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The proposed project will address a critical need for effective intervention approaches for psychiatrically hospitalized suicidal adolescents, who remain at high risk for recurrent suicidal behavior and related crises following hospital discharge. Leveraging a novel sequential multiple assignment randomized trial (SMART) design, the project will identify an optimal technology-augmented adaptive intervention that will guide the delivery of post-discharge support—provided via text messages and booster calls—in an adaptive way that minimizes resources and burden. Findings from this study hold promise to inform urgently needed intervention strategies for reducing suicide-related outcomes among adolescents transitioning from inpatient care.

PI_NAMEs: CZYZ, EWA KARINA (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: 17 year old;acceptability and feasibility;Acute;adaptive intervention;Address;Adolescent;adverse outcome;Age;Area;Cause of Death;Cellular Phone;Classification;comparative efficacy;Continuity of Patient Care;coping;Coping Skills;cost;design;effective intervention;Emergency department visit;Environment;Event;Feeling suicidal;Funding;Goals;Health behavior and outcomes;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitalized Adolescent;Hospitals;ideation;Impairment;improved;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;Interruption;Intervention;Link;Mediating;mobile computing;Motivation;motivational enhancement therapy;multi-component intervention;National Institute of Mental Health;novel;novel strategies;Outcome;Parents;personalized intervention;Phase;prevent;primary outcome;Procedures;Psychiatric therapeutic procedure;Public Health;Randomized;Recurrence;reducing suicide;Research;Resources;response;Risk;Safety;secondary outcome;Self Efficacy;Sequential Multiple Assignment Randomized Trial;Services;Severities;sex;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surveys;Technology;Teenagers;Testing;Text Messaging;texting support;Time;treatment response;treatment strategy;trial design;United States;Youth

PROJECT_TITLE: Adaptive intervention to prevent adolescent suicidal behavior following psychiatric hospitalization: A Sequential Multiple Assignment Randomized Trial

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Cachexia;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Skeletal muscle cells have a remarkable capacity to increase their size in response to exercise, and to decrease size upon inactivity, aging, or disease. Despite the importance of skeletal muscle cell size to its function, the mechanisms that regulate muscle cell size and its organelle scaling are poorly understood. We will quantify and mathematically model different parameters of muscle cell size in normal, hypertrophic, and atrophic conditions, determine how these integrate with neural activity and mechanical forces, and finally determine the functional definition of the individual myonuclear domains within the muscle cell in vivo and on a single cell level.

PI_NAMEs: BAYLIES, MARY K (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Aging;Area;Atrophic;Basic Science;Biological;Cachexia;Cell fusion;Cell Nucleus;Cell Size;Cells;Centronuclear myopathy;Communication;Compensation;Cytoplasm;Cytoplasmic Tail;Disease;Drosophila genus;Exercise;Genes;Genetic;Goals;Growth;Human body;Hypertrophy;Image;in vivo;Individual;insight;Investigation;Length;Malignant Neoplasms;mathematical methods;mathematical model;mechanical force;Mission;Molecular;Movement;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Muscular Atrophy;Myopathy;Nemaline Myopathies;neural;novel;Nuclear;Organelles;Physiological;Ploidies;Positioning Attribute;Process;Regenerative Medicine;regional difference;Regulation;Regulation of Cell Size;Research;response;Rhabdomyosarcoma;Signal Transduction;Skeletal Muscle;soft tissue;Work

PROJECT_TITLE: Sizing and Scaling in Functional Muscle Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]