ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The project proposes to use transcranial magnetic stimulation to modulate the brain circuitry associated with nicotine addiction and schizophrenia, and to determine whether it would help patients to reduce and quit smoking.

PI_NAMEs: DU, XIAOMING ;HONG, L ELLIOT ELLIOT (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Amygdaloid structure;Blinded;brain circuitry;cigarette smoking;Clinical;clinical efficacy;Data;design;Disease;Dose;FDA approved;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;General Population;Genetic Risk;Hippocampus;Image;image guided;Impairment;improved;indexing;Intervention;Learning;Link;Location;Measures;Mental Depression;Modification;neural circuit;Nicotine Dependence;novel strategies;Outcome;Outcome Assessment;Patient Recruitments;Patients;Phase;Prefrontal Cortex;Prevalence;Public Health;Randomized;randomized trial;repetitive transcranial magnetic stimulation;Reporting;Research;response;Rest;Risk;risk sharing;Schizophrenia;schizophrenia spectrum disorder;Severities;Site;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;stability testing;success;Testing;Tobacco smoking behavior;Transcranial magnetic stimulation;treatment duration;trend

PROJECT_TITLE: Circuitry-Guided Smoking Cessation in Schizophrenia


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project will investigate the role of NAMPT dependent pathways in the development of pulmonary hypertension, an incurable disease associated with high mortality.

PI_NAMEs: MACHADO, ROBERTO F. (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Anabolism;Animal Model;Apoptosis;Biochemical;biological adaptation to stress;Biological Markers;Blood Vessels;cell growth regulation;cell motility;Cell Proliferation;Cell Survival;Cells;Characteristics;chemotherapeutic agent;cytokine;Data;Development;Disease;Endothelial Cells;Experimental Animal Model;extracellular;Functional disorder;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Genetic Variation;Growth Factor;In Situ;In Vitro;in vivo;Inflammatory;Inflammatory Response;Injury;Link;Malignant Neoplasms;Mediator;Metabolic;Mitochondria;Molecular;mortality;Niacinamide;nicotinamide phosphoribosyltransferase;novel;novel marker;Oxidation-Reduction;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Plasma;Play;precursor cell;predicting response;Predisposition;Process;Production;Prognosis;Proliferating;Proteins;Publishing;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;Regulation;Resistance;response;Role;senescence;Signal Transduction;Smooth Muscle Myocytes;Testing;therapeutic target;Thrombosis;translational study;Translations;vascular inflammation;Vascular remodeling;vasoconstriction;Vision

PROJECT_TITLE: NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Our proposed studies address how sigaling molecules converge on chromatin to regulate chromatin remodeling, tissue-specific gene expression and tissue differentiation. Using skeletal muscle differentiation as a model, our work will provide molecular mechanisms defining how signaling pathways modify a specific chromatin remodeling enzyme to mediate embryonic and adult skeletal muscle differentiation and maintenance. The work will have significant impact on our overall understanding of muscle development in the embryo and muscle regeneration in the adult. This work will also increase our understanding of changes that occur in muscle diseases where increased muscle growth (hypertrophy) or reduced muscle development (hypotrophy) are exhibited and on the formation of rhabdomyosarcomas, which are tumors of myogenic derivation.

PI_NAMEs: IMBALZANO, ANTHONY N (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Adult;Binding;Cell Cycle Regulation;Cell Lineage;Cell Physiology;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Derivation procedure;Development;Embryo;Embryonic Development;Enzymes;Exhibits;Family member;Gene Activation;Gene Expression;Gene Expression Regulation;Gene Order;Gene Structure;Genetic Transcription;Genome;Genomic DNA;Growth;Hypertrophy;In Vitro;in vivo;inhibitor;Maintenance;Mediating;Methods;Modeling;Molecular;Muscle;Muscle Development;muscle regeneration;Mutagenesis;Myoblasts;Myopathy;Normal Cell;Nucleosomes;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Process;programs;Proliferating;Rhabdomyosarcoma;Role;Signal Pathway;Signaling Molecule;skeletal muscle differentiation;Structure;Study models;Tissue Differentiation;Tissue-Specific Gene Expression;transcription factor;tumor;Tumor Promoters;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Regulation of gene expression by chromatin remodeling enzymes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH End-stage renal disease (ESRD) is most effectively treated by renal transplantation, but 46% of deceased- donor and 28% of living-donor grafts will fail by ten years after transplantation predominantly (63%) due to chronic antibody-mediated rejection (AMR). AMR is currently detected by invasive biopsy with associated safety risks. The goal of this work is to develop an ultrasound-based, noninvasive alternative to biopsy to safely detect AMR and monitor its response to treatment.

PI_NAMEs: GALLIPPI, CATERINA M (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Allografting;Anisotropy;Antibodies;antibody detection;antibody-mediated rejection;Award;B-Lymphocytes;Biological Markers;Biopsy;Blood Vessels;Chronic;Clinical;Clinical Trials;Creatinine;Detection;detection method;Development;Diagnostic;donor-specific antibody;Early Diagnosis;Elasticity;End stage renal failure;Evaluation;Feasibility Studies;Fibrosis;Funding;Goals;graft dysfunction;graft failure;Graft Survival;Grant;Human;Image;imaging modality;immunoregulation;Immunosuppression;implantation;improved;in vivo;in vivo Model;indexing;Inflammation;Intervention;Intravenous Immunoglobulins;Investigation;Kidney;Kidney Transplantation;Life;Living Donors;Measurable;Measurement;Measures;Mechanics;Mediating;Methods;Monitor;Non-Invasive Detection;non-invasive monitor;novel strategies;Operative Surgical Procedures;Outcome;Pathologic;Patient imaging;Performance;Persons;Physiologic pulse;Plasmapheresis;porcine model;Proteinuria;Protocols documentation;Public Health;remediation;Research;Research Design;Resistance;response;Risk;Risk Factors;Safety;Sampling;Sensitivity and Specificity;serial imaging;Serum;Standardization;Steroids;success;Surrogate Markers;Survival Rate;T-Lymphocyte;Technology;Therapeutic Intervention;Thinness;Time;Translations;Transplant Recipients;Transplantation;treatment choice;Treatment Protocols;treatment response;Ultrasonography;ultrasound;United States;United States Food and Drug Administration;Urine;Variant;viscoelasticity;Viscosity;Work

PROJECT_TITLE: VisR Ultrasound for Monitoring Antibody-Mediated Rejection in Renal Transplant Patients


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Crohn’s disease is an inflammatory bowel disease that has no cure and often leads to disease complications requiring bowel resection surgery. The origin of two phenomena correlating with development of Crohn’s disease complications, mesenteric adipose tissue wrapping around inflamed intestine, or “creeping fat”, and circulating anti-microbial antibodies, are poorly understood. By studying how Crohn’s disease-specific bacterial translocation to mesenteric adipose tissue leads to activation of stromal cells and adipocytes, in turn driving inflammatory B cell responses, this proposal has the potential to uncover mechanisms underlying CD pathology, identify novel therapeutic targets, and expand the study of mucosal immunology to mucosa-associated adipose tissues.

PI_NAMEs: GRASSET, EMILIE K  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adipocytes;adipokines;Adipose tissue;Affect;Antibodies;Antigen Receptors;Antigens;antimicrobial;Automobile Driving;B-Cell Activation;B-Lymphocytes;Bacteria;Bacterial Antigens;Bacterial Translocation;Biopsy;Cell Communication;Cell Physiology;Cells;Chronic;Collection;comparison control;Crohn's disease;cytokine;Data;Development;Diagnosis;Disease;disease diagnosis;Etiology;Excision;Fatty acid glycerol esters;Flow Cytometry;Genes;genetic signature;Genetic Transcription;Germ-Free;Gnotobiotic;gut inflammation;Gut Mucosa;Human;IgA Deficiency;Immune system;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunology;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestines;Lead;Left;Leptin;Ligation;Lymphoid;Mesentery;Microbe;microbiota;Modeling;Mucous Membrane;murine colitis;Mus;new therapeutic target;Operative Surgical Procedures;Pathogenicity;Pathologic;Pathology;Patients;Phenotype;Plasma Cells;Production;Proliferating;Property;Proteins;reconstitution;recruit;response;Serum;Signal Transduction;Stromal Cells;therapeutic target;Tissue Expansion;Tissues;Toll-like receptors;transcriptome sequencing

PROJECT_TITLE: Bacterial translocation to mesenteric adipose tissue drives pathogenic stromal-B cell interactions leading to inflammatory IgG

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative This proposal addresses the emerging concern that paternal exposure to toxicants such as arsenic affects sperm quality and male fertility in offspring. It seeks to identify unique changes in sperm RNAs that explain the intergenerational effects and the sensitive period in the life course to such insult. Its long-term goal is to understand how gene-environment interactions bring about the disease across generations through modified small RNA population.

PI_NAMEs: HO, SHUK-MEI  (contact);LEUNG, YUET-KIN

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Arsenic;base;Child;Code;contaminated drinking water;Development;Diet;Disease;Dose;drinking water;early life exposure;Environment;environmental stressor;Epigenetic Process;epitranscriptome;epitranscriptomics;Exposure to;Fathers;Female;Food;gene environment interaction;Generations;Geographic Locations;Goals;Hazardous Waste Sites;Immunoprecipitation;Impairment;Individual;Infant;Inherited;intergenerational;Lead;Life;Life Cycle Stages;male;male fertility;Male Genital Organs;Maps;Mediating;Mediator;Microinjections;MicroRNAs;Modeling;Modification;Molecular;Morphology;Motility;Mus;nanopore;novel;Nucleosides;Nucleotides;Occupational Exposure;offspring;Organogenesis;Parents;Partner in relationship;Paternal Exposure;Persons;Phase;Phenotype;Pilot Projects;piRNA;pollutant;poor health outcome;Population;postnatal;Predisposition;Pregnancy;prenatal exposure;Protocols documentation;Pseudouridine;Puberty;Reporting;reproductive;reproductive outcome;reproductive toxicity;RNA;Rodent Model;Role;Small Nucleolar RNA;Small RNA;Son;sperm cell;sperm quality;Testing;Time;Toxic Environmental Substances;toxicant;trait;transcriptome;transcriptome sequencing;transcriptomics;Transfer RNA;transmission process;Weaning;zygote

PROJECT_TITLE: RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The successful completion of this project will lead to new insights into mechanisms involved in the pathophysiology of type 2 diabetes mellitus and will advance an innovative method to ameliorate these disease mechanisms. This work also has the potential to identify novel metabolic pathways including redox biomarkers as therapeutic targets for diabetes. Importantly, the successful completion of this work will pave the way for the clinical application of a novel, noninvasive modality for the management of type 2 diabetes.

PI_NAMEs: ABEL, E DALE;SHEFFIELD, VAL C. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Adherence;Adverse effects;Animals;Antioxidants;Biological Availability;Biological Markers;Biology;Carbon;Catabolism;catalase;Cells;clinical application;clinical development;Clinical Trials;Diabetes Mellitus;Disease;Drug Modulation;Electromagnetic Energy;Electromagnetic Fields;Electrons;Electrostatics;Equilibrium;Fatty Acids;Foundations;Functional disorder;Future;Genetic;Glucose;Glucose Intolerance;glucose metabolism;glucose uptake;Glutathione;Glutathione Disulfide;Glycogen;Goals;Hepatic;Hepatocyte;Homeostasis;Hour;Human;Hydrogen Peroxide;Hypoglycemic Agents;improved;in vivo;Infusion procedures;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Knockout Mice;Link;lipid biosynthesis;Liver;Malignant Neoplasms;Mediating;Medicine;Mental Depression;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Modality;mouse model;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;non-invasive system;novel;novel marker;nucleotide metabolism;Obesity;overexpression;Oxidation-Reduction;Pathway interactions;Patients;Penetration;Pentosephosphate Pathway;pharmacologic;Planet Earth;prevent;Production;Property;Protein Isoforms;Publications;Reactive Oxygen Species;Regulation;response;Risk;Rodent;Role;side effect;Signal Transduction;Superoxide Dismutase;Superoxides;Surface;System;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;tool;Tracer;Transcranial magnetic stimulation;Translating;tumor;wearable device;Work

PROJECT_TITLE: Modulating ROS by Electromagnetic Fields to Treat Type 2 Diabetes

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The National Academy of Sciences has identified a critical shortage of veterinarians in biomedical research careers. The proposed training program provides veterinary students early in their veterinary school careers with training in all aspects of biomedical research, and provides them with information and advice on biomedical research careers. Outcomes data indicate that Program graduates are much more likely to pursue further education, PhD training, and research careers in academia, industry, or government, and are less likely to pursue private practice clinical careers.

PI_NAMEs: ATCHISON, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academia;Address;animal model development;Animals;Biomedical Research;career;career development;Credentialing;Data;Education;Environment;experience;Faculty;faculty mentor;Funding;Government;Grant;Health;Health Professional;Human;human disease;Industry;Infectious Diseases Research;Laboratories;Manuscripts;Mentors;National Research Council;Oral;Outcome;Pennsylvania;Philadelphia;Physicians;posters;Private Practice;programs;Public Health;Publications;Qualifying;recruit;Reporting;Research;Research Infrastructure;Research Proposals;Research Training;Schools;Science;Scientist;Strategic Planning;Stress;Students;summer research;symposium;Training;United States National Academy of Sciences;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;Writing

PROJECT_TITLE: Short-term Training: students in health professional schools


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Neurosciences

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Maternal responses to stress have long-term effects on offspring, through as yet poorly undertood mechanisms. We have discovered that the stress-induced release of serotonin from maternal neurons in C. elegans enables the transcription factor, HSF1 to modify chromatin in pre-fertilized oocytes through a piRNA-mediated chromatin silencing mechanism, and thereby influence offspring development and stress-resilience. Here we propose to understand the molecular mechanisms by which this occurs.

PI_NAMEs: PRAHLAD, VEENA  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Ablation;Acute;Affect;Afferent Neurons;Aging;Animals;anti-depressive agents;base;Behavior;behavioral response;Biogenesis;Biological Models;Caenorhabditis elegans;Cellular Stress;Chromatin;chromatin remodeling;Complex;Data;Decidua Basalis;Development;differential expression;Disease;Ectopic Expression;effective therapy;Embryo;Enterochromaffin Cells;Enzymes;Epigenetic Process;experimental study;forward genetics;Foundations;Future;gene repression;Genes;Genetic Transcription;genome-wide;genomic locus;Germ Cells;Germ Lines;Health;heat shock transcription factor;Histones;Homologous Gene;HSF1;IGF-1 Signaling Pathway;Individual;Insulin;Insulin Receptor;Long-Term Effects;Lysine;Major Depressive Disorder;Mammalian Cell;Mammals;maternal stress;Mediating;Memory;Methyltransferase;model organism;Modeling;Modification;Molecular;Mood Disorders;Mothers;Nematoda;neural;neurodevelopment;Neuromodulator;Neurons;offspring;Oocytes;optogenetics;Orthologous Gene;Parents;Pathway interactions;Perception;Physiology;piRNA;Polycomb;Process;programs;promoter;Proteins;Receptor Gene;Receptor Mediated Signal Transduction;receptor-mediated signaling;recruit;Repression;Research;Resistance;response;reverse genetics;RNA;Role;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;serotonin receptor;SETDB1 gene;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Source;Stress;stress resilience;transcription factor;transmission process;Work

PROJECT_TITLE: Investigating how stress induced changes in maternal serotonin affect offspring development and stress resilience

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: The current treatment strategies have failed patients diagnosed with diffuse midline glioma (DMG) driven by oncogenic histone H3 mutations (H3.3K27M and H3.1K27M) as less than 20% of patients will survive two years post-diagnosis. The overall goals of this research are to characterize novel roles for genes regulating Pol II transcriptional elongation in promoting DMG tumorigenesis and to determine how H3K27M mutant histones co- opt the activity of specific elongation factors to induce aberrant transcription underlying DMG malignancy.

PI_NAMEs: ANASTAS, JAMIE N. (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Ablation;Adult;Antineoplastic Agents;Automobile Driving;Binding;Binding Sites;Brain Neoplasms;brain tissue;cancer cell;cancer therapy;cell type;Cells;Chemicals;Child;Childhood;Chromatin;chromatin modification;Chromatin Structure;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Data;Defect;Dependence;Development;Diagnosis;Diffuse;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;DNA Polymerase II;effective therapy;Elongation Factor;elongin;elongin B;epigenome;Exhibits;Gene Abnormality;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome-wide;Genomics;Glioma;Gliomagenesis;Goals;Growth;H3 K27M mutation;Histone H3;Histones;improved;inhibitor;insight;Investigation;Knock-out;Knowledge;Link;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Molecular;mouse model;Mus;mutant;Mutation;next generation sequencing;nonsynonymous mutation;Normal Cell;Normal tissue morphology;novel;Oncogenes;Oncogenic;Output;overexpression;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Polymerase;Pontine structure;pre-clinical;programs;Proliferating;Proteins;Regulation;Regulatory Pathway;Research;RNA Polymerase II;Role;Somatic Mutation;targeted treatment;tissue culture;Transcription Elongation;transcriptome sequencing;transcriptomics;treatment strategy;tumor;tumor growth;tumor initiation;tumor progression;Tumor Suppressor Proteins;tumorigenesis;VHL protein;Von Hippel-Lindau Tumor Suppressor Protein;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: MECHANISMS OF POL II ELONGATION IN DIFFUSE MIDLINE GLIOMA

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative. CCNE1-amplified ovarian cancer is among the most aggressive forms of ovarian cancer and is associated with primary treatment resistance and reduced overall survival. Despite intense efforts, targeted therapies for the treatment of this disease remain elusive, in part, due to the paucity of druggable molecular targets. Here we present a new approach to selectively target CCNE1-amplified ovarian cancer and describe novel small- molecules that will enable the preclinical evaluation of this strategy.

PI_NAMEs: GRAY, NATHANAEL SCHIANDER (contact);KONSTANTINOPOULOS, PANAGIOTIS

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: analog;Biological Availability;Biological Markers;biomarker identification;cancer cell;Cancer cell line;cancer genetics;Cancer Science;CCNE1 gene;Cell Cycle;Cell Death Induction;Cell Line;Cellular biology;Chemicals;chemotherapy;Clinical;Combined Modality Therapy;Cyclin-Dependent Kinases;Cytotoxic Chemotherapy;Data;Dependence;Development;Disease;Drug Exposure;Drug Kinetics;druggable target;efficacy study;Exhibits;experimental arm;Generations;Genes;Genetic;Genomics;Goals;Half-Life;Hour;Human;improved;in vivo;in vivo evaluation;inhibitor;knock-down;Knowledge;Lead;lead candidate;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Medical;medical schools;Molecular Target;mouse model;multidisciplinary;Mus;neoplastic cell;novel;novel strategies;novel therapeutics;Oral;Outcome;Ovarian;Ovarian Serous Adenocarcinoma;overexpression;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphotransferases;Plasma;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical development;preclinical evaluation;Property;Proteomics;Rattus;Research;Resistance;resistance mechanism;response;Sampling;scaffold;Series;small molecule;Specificity;Structure;synergism;Systems Biology;targeted treatment;therapy resistant;transcriptome sequencing;treatment strategy;tumor;Xenograft procedure

PROJECT_TITLE: Targeting CDK7 in CCNE1-amplified Ovarian Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE Children with brain cancer have a dismal prognosis and urgently need new therapy options. This project will investigate “theranostic” (combined therapeutic and diagnostic) nanoparticles (TNPs) activated by specific tumor enzymes to release the highly potent therapeutic drug azademethylcolchicine. Because TNPs are only activated in brain cancers, this strategy circumvents dose-limiting toxic effects to the normal brain, and can lead to substantially more efficacious brain cancer therapies than currently available.

PI_NAMEs: DALDRUP-LINK, HEIKE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Adult;Affect;Animals;antiangiogenesis therapy;antitumor effect;Apoptosis;Binding Sites;Biosensor;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain Neoplasms;cancer therapy;Cell Death;cell killing;Cells;Child;Childhood;Childhood Malignant Brain Tumor;clinical translation;Colchicine;conventional therapy;curative treatments;cytotoxic;Data;density;design;Development;Diagnosis;Diagnostic;Disease remission;Dose;Dose Limiting;Drug Delivery Systems;Drug Monitoring;Endothelial Cells;Endothelium;Enzymes;FDA approved;Fluorescein-5-isothiocyanate;Fluorescence Microscopy;Formulation;Generations;Glioblastoma;Glioma;Goals;High Prevalence;Horseradish Peroxidase;improved;improved outcome;in vivo;interest;intravenous administration;intravital microscopy;iron oxide nanoparticle;Label;Link;Location;macromolecule;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Mean Survival Times;Measures;Mediating;Microtubules;Mitosis;MMP14 gene;Modeling;Mus;nanocarrier;nanoparticle;Nature;neoplastic cell;neuro-oncology;novel;novel drug class;novel strategies;novel therapeutics;Nutritional;Organ;Outcome;overexpression;Pediatric Neoplasm;Peptide Hydrolases;Perivascular Neoplasm;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Placebos;Positioning Attribute;Prodrugs;Prognosis;Proteins;Radiation;Rattus;real time monitoring;Recurrent disease;Research;side effect;Site;Starvation;success;System;theranostics;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapy resistant;Toxic effect;Treatment Efficacy;Tubulin;tumor;tumor growth;Tumor Suppression;Tumor Tissue;Vascular Endothelial Cell;Vascularization;Visceral

PROJECT_TITLE: Theranostics for Pediatric Brain Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: With advanced age there is an increased likelihood of disturbances that impact the quality and quantity of sleep. Unraveling the underlying mechanisms that contribute to sleep disturbances in aging – which may lead to new therapeutic approaches to alleviate these outcomes– is of great importance. The following proposal is designed to test the novel hypothesis that kynurenic acid represents is a key molecular link between aging and sleep disturbances.

PI_NAMEs: POCIVAVSEK, ANA  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acute;Address;age related;age related changes;Age-associated memory impairment;Aging;aging brain;animal old age;Animals;Astrocytes;Attention;basal forebrain;Behavior;Behavioral;Brain;Brain region;Catabolism;cholinergic;Cholinergic Antagonists;Chronotherapy;circadian;Cognition;Cognitive;combat;Data;design;Deterioration;Elderly;Electroencephalography;Endocrine;Enzymes;Experimental Designs;extracellular;Fatigue;Functional disorder;Gene Transfer;Headache;Homeostasis;hypocretin;Hypothalamic structure;Immunohistochemistry;Impaired cognition;Impairment;improvement on sleep;in vivo;inhibitor;interest;Kynurenic Acid;Kynurenine;Kynurenine-oxoglutarate aminotransferase;Lateral;Link;Mediating;Microdialysis;Molecular;Neurons;neurotransmission;non rapid eye movement;novel;novel therapeutic intervention;Organism;Outcome;Pathway interactions;Periodicity;pharmacologic;Pharmacological Treatment;Phase;Physiological;Play;prevent;Rattus;Regulation;REM Sleep;response;Role;Signal Transduction;Sleep;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep quantity;sleep regulation;Sleep Wake Cycle;small molecule;Source;Testing;Time;tool;transmission process;treatment duration;Tryptophan;Virus;Wakefulness

PROJECT_TITLE: Aging, sleep, and kynurenic acid

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Glioblastoma is the most common cancer originating in the brain with ~12,000 new diagnoses per year in the U.S.A. and median survival about 18 months. Miami has formed a partnership with ViewRay Inc., makers of a new combination MRI and radiation therapy (RT) device (MRIdian), to improve daily MRI acquisition and processing during RT to identify early glioblastoma growth. Using this data, we will identify glioblastomas that would benefit from earlier, more aggressive intervention to improve survival of patients with glioblastoma.

PI_NAMEs: MELLON, ERIC ALBERT (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Address;Agreement;Anatomy;automated segmentation;Biopsy;Brain;Brain Neoplasms;Cellularity;chemotherapy;Classification;Clinical;clinical translation;Collaborations;Computer software;Data;deep learning;design;Detection;Development;Devices;Diagnostic;Diffusion;disabled;Dose;Early identification;Excision;Future;Gadolinium;Generations;Glioblastoma;Goals;Growth;high risk;Hypoxia;Image;image processing;Imaging Techniques;improved;industry partner;Inflammation;innovation;Institution;Institutional Review Boards;Intervention;Kinetics;Lesion;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Manuals;Maps;Measurement;member;Metabolism;Mission;Modeling;Motion;National Cancer Institute;neovascularization;neuroimaging;Newly Diagnosed;Outcome;Patient-Focused Outcomes;Patients;Perfusion;perfusion imaging;Periodicals;Phase;Physiological;Physiology;Pilot Projects;Preparation;Process;Prognosis;prospective;Protocols documentation;quantitative imaging;Radiation therapy;radiomics;Research;response;Scanning;Spectrum Analysis;System;Techniques;temozolomide;Testing;Translating;treatment response;trend;tumor;tumor growth;Tumor Volume;Validation;validation studies;Work

PROJECT_TITLE: A Physiologic Adaptive Radiation Therapy Pipeline for Glioblastoma by Daily Multiparametric MRI and Machine Learning


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative - The role of liver progenitor cells in liver regeneration In the proposed work, we will utilize a severe hepatocyte injury model in adult zebrafish combined with single-cell transcriptomic and high-resolution imaging analyses to investigate whether and when biliary epithelial cells undergo transcriptional and morphological changes to become hepatocytes. We will elucidate the role of biliary epithelial cells as facultative liver stem cells and define signaling pathways to enhance liver regeneration. The results of this work may reveal therapeutic opportunities to enhance biliary-derived liver regeneration after severe hepatocyte injury.

PI_NAMEs: GOESSLING, WOLFRAM  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Acetaminophen;Acute;Adult;adult stem cell;Affect;airway epithelium;Atlases;Bile fluid;Biliary;Blood;cell type;Cells;Cessation of life;Chemicals;Chronic;chronic liver disease;COVID-19 pandemic;Data Set;Dedications;Development;Endoderm Cell;Epidermal Growth Factor Receptor;Epithelial Cell Proliferation;Epithelial Cells;Equipment and supply inventories;Experimental Autoimmune Encephalomyelitis;experimental study;Fibrosis;Fishes;FRAP1 gene;Gallbladder;Gene Expression;Generations;Genetic;Genetic Transcription;Goals;Hepatic;Hepatocyte;hepatocyte injury;high resolution imaging;Homeostasis;Human;Inflammation;Injury;insight;Intestines;Liver;liver development;Liver Failure;liver function;liver injury;Liver Regeneration;liver repair;Liver Stem Cell;Maps;Mediating;Metabolic;Methods;Microscopy;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mTOR Signaling Pathway;Mus;Muscle;Natural regeneration;novel;Organ;organ growth;organ regeneration;Outcome;oval cell;Partial Hepatectomy;Pathway interactions;Patients;Phenotype;PIK3CG gene;Population;Process;progenitor;Proliferating;Rattus;regenerative;Regenerative capacity;Regenerative response;Reporter;Resolution;response to injury;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;stem cell population;stem cells;Therapeutic;Therapeutic Intervention;timeline;Tissues;tool;transcription factor;transcriptomics;Work;Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the neural mechanisms of attention, the subject of this project, are central to human cognition and its impairments in a wide range of neurological and psychiatric disorders, including hemispatial neglect and simultagnosia. Studies proposed in this application will determine the neural circuits and elucidate the neural mechanisms that control the focus of attention, a core cognitive function. Thus the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: FREIWALD, WINRICH  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Area;Attention;attentional control;Behavior;Brain;brain control;Code;Cognition;Cognitive;cognitive control;cognitive function;cognitive neuroscience;Coupling;covert attention;Data;Diagnosis;Diffusion;disability;Dorsal;Electric Stimulation;Electrophysiology (science);Experimental Models;Face;face perception;flexibility;Functional Magnetic Resonance Imaging;Goals;Hemispatial Neglect;Human;Image;Impaired cognition;Impairment;information processing;Injections;innovation;interest;Investigation;Joints;Knowledge;Lateral;Macaca;Measurement;Mental disorders;Methodology;Mission;multimodality;Nervous System Disorder;neural;neural circuit;neural network;Neurologic;Neurology;neuromechanism;nonhuman primate;Outcome;Parietal;Population;Primates;Process;Public Health;Research;Rest;selective attention;Sensory;Source;Specificity;Stroke;Structure;sustained attention;System;Systems Analysis;Temporal Lobe;Testing;Tracer;United States National Institutes of Health;Visual;Visual attention;visual control;visual processing;Work

PROJECT_TITLE: Defining the Neural Circuits of Attention Control: A New Hypothesis

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Despite intensive efforts to understand the molecular mechanism underlying the neuroadaptations associated with addiction phenotypes, current knowledge can only partially explain which cell type orchestrates specific transcriptional responses to addictive drugs in the brain. By systematically analyzing the cell-type specific transcriptional and chromatin accessibility changes that occur in brain regions of rat with different history of oxycodone use, this application aims to provide unprecedented insights in the biological basis of opiate addiction. This project focuses on the emerging and complex problem of prescription pain relievers and opioids abuse in this country.

PI_NAMEs: TELESE, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Acceleration;addiction;Address;Affect;American;Animals;base;Behavior;behavior measurement;Behavioral;Behavioral Model;Behavioral Paradigm;Binding;Binding Sites;biobank;Biological;Biological Assay;Brain;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Cerebral cortex;ChIP-seq;Chromatin;Complex;Computer Analysis;cost;Country;Data;Data Set;Dependence;Development;Disease;Distal;DNA;DNA Sequence;Drug abuse;Drug Addiction;Drug Modelings;Drug Prescriptions;Drug usage;Epidemic;Epigenetic Process;epigenomics;Exhibits;experience;experimental study;Face;Fentanyl;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic association;Genetic Transcription;Genetic Variation;genome wide association study;Genotype;Goals;Grant;Heroin;Human;Illicit Drugs;Individual;Individual Differences;infancy;insight;Intake;Intravenous;Knowledge;Ligation;Link;Maps;Measures;Methods;Modeling;Molecular;molecular dynamics;Motivation;multidisciplinary;National Institute of Drug Abuse;neural circuit;neuroadaptation;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid overdose;Overdose;Oxycodone;oxycodone self-administration;Pattern;Pharmaceutical Preparations;Phenotype;Population;Population Heterogeneity;Predisposition;prescription pain reliever;Procedures;Public Health;Rattus;Recording of previous events;Regulatory Element;Research Personnel;Resistance;Resolution;Resources;response;Sampling;Severities;Signal Transduction;single cell analysis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Technology;Tissue Banks;Tissues;trait;transcription factor;transcriptomics;United States;United States National Institutes of Health

PROJECT_TITLE: Single-cell resolution analysis of chromatin accessibility and gene expression changes in a model of drug addiction


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Our genetic material, albeit being nearly identical from one person to another, is littered with many variations, some of which are associated with the development and progression of Alzheimer's Disease (AD). In this project, we are proposing a robust and economical approach that will enable identification and study of AD-associated genetic variations. The resulting data is expected to transform our mechanistic understanding of disease progression, and identify potential targets for therapeutic intervention.

PI_NAMEs: GAN, LI ;LIS, JOHN T;YU, HAIYUAN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Affect;aging population;Alleles;Alzheimer's Disease;Architecture;Base Pairing;Binding;Biological Assay;Cell Line;cell type;Cells;Characteristics;Chromatin;Chromatin Conformation Capture and Sequencing;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Data Set;Dementia;Development;Disease;Disease Pathway;disease phenotype;Disease Progression;Distal;Elements;Enhancers;excitatory neuron;Gene Expression Regulation;Gene Mutation;gene regulatory network;Genes;Genetic Enhancer Element;Genetic Materials;Genetic Transcription;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;genomic locus;Genomics;Goals;Healthcare Systems;high throughput screening;Human Genome;induced pluripotent stem cell;Maps;Measures;Microglia;Modeling;Molecular;molecular targeted therapies;Mutagenesis;mutant;Mutation;Needles;Pathologic;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Precision Run-On Sequencing;Predisposition;Prognosis;promoter;Protocols documentation;rare variant;Regulation;Regulator Genes;Resolution;RNA;Sampling;synergism;targeted treatment;Testing;Therapeutic Intervention;Transcription Coactivator;transcription factor;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Genome-wide identification and characterization of Alzheimer's Disease-associated enhancers

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric

PHR: PROJECT NARRATIVE The project provides a novel framework for integrating science inquiry with reading/English language arts (ELA) for students in grades 4-5. The strategies employed are designed to contribute to equitable access by students to high quality science learning experiences that build science identity and persistence in pathways to science careers.

PI_NAMEs: MORENO, NANCY P (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Achievement;Address;African American;Area;Belief;Biological Sciences;career;college;Communicable Diseases;Communication;Communities;Community of Practice;comparison group;cost;County;curriculum development;Data;design;Development;disadvantaged student;Discipline;economic disparity;Education;Educational Curriculum;Educational process of instructing;Effectiveness;elementary school;English Language;Enrollment;Environmental Health;Equity;Evidence based program;experience;field study;Funding;Genetic;Grant;Growth;Health;Hispanic;Home;implementation design;improved;innovation;inquiry-based learning;Instruction;interest;Investigation;Knowledge;Language;Latino;Learning;literacy;Location;mathematical ability;Mathematics;Measures;Medicine;member;Municipalities;Neurosciences;novel;novel strategies;Outcome;Pathway interactions;Performance;pilot test;Population;programs;Randomized;Reading;Research;Resources;school district;Schools;Science;Scientist;Site;skills;STEM career;student participation;Students;Target Populations;teacher;Teacher Professional Development;Texas;Text;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;urban school;web site;Woman;Work;Writing

PROJECT_TITLE: Authentic Literacy and Language (ALL) for Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Breast cancer is only rarely cured by chemotherapy because tumor cells can survive by entering cellular senescence, which results in early relapse and poor patient survival. Senescence enables evasion of death by mitotic catastrophe and apoptosis by arresting the cell cycle, and, as we recently discovered, death by nutrient depletion is averted by a novel cell engulfment phenotype. The goal of this project is to identify the mechanisms of immune evasion by senescent cells and how this can be therapeutically targeted.

PI_NAMEs: JACKSON, JAMES  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Aftercare;anti-PD-L1;anti-PD-L1 therapy;Apoptosis;Apoptotic;Bioinformatics;Breast;Breast Cancer Model;Breast Cancer Patient;cancer therapy;cancer type;Cell Aging;Cell Cycle Arrest;Cell Death;Cell Survival;Cells;Cessation of life;checkpoint inhibition;chemokine;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;cytokine;Data;Effectiveness;efficacy evaluation;exhaustion;Failure;Gene Expression;Gene Expression Profile;Genes;Goals;Growth;Harvest;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune clearance;Immune Evasion;Immune Targeting;immunogenic cell death;Immunohistochemistry;Immunologics;Immunology;Immunotherapy;improved;in vivo;Interferon Type II;Interferons;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Messenger RNA;mimetics;Mitotic;Modeling;Mouse Mammary Tumor Virus;mouse model;Mus;mutant;Neoplasm Transplantation;neoplastic cell;novel;novel strategies;novel therapeutics;Nutrient;Nutrient Depletion;nutrient deprivation;Oncologist;Pathologic;Patients;Phagocytes;Pharmaceutical Preparations;Phenotype;polyoma middle tumor antigen;Population;predicting response;predictive signature;pressure;prevent;Production;programmed cell death ligand 1;programs;Proteins;Relapse;Research;Research Design;Residual Neoplasm;Resistance;response;retransplantation;Retreatment;Sampling;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Series;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Sorting;Specimen;Stains;statistics;Stromal Cells;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TP53 gene;Transplantation;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Escape;Up-Regulation

PROJECT_TITLE: Targeting mechanisms of immune evasion in chemotherapy-induced senescent cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Although the current SARS-CoV-2 vaccines have shown impressive protective capacity upon subsequent exposure, recent emergence of new viral variants threaten to significantly reduce the efficacy of these vaccines. Whether lung resident anti-viral memory T cells are generated and can promote a second line of protection against SARS-CoV-2 infection is currently unknown. In this proposal we will study the ability of SARS-CoV-2 infection or vaccination to promote tissue resident memory T cell generation in mice and humans and whether these memory T cell populations can provide significant protective ability in animal models.

PI_NAMEs: FARBER, DONNA L.;KAECH, SUSAN M;TEIJARO, JOHN ROSS (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;Age;Animal Model;Anti-viral Therapy;Antibodies;antiviral immunity;B-Lymphocytes;Blood;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;Complement;Coronary heart disease;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 pandemic;COVID-19 vaccine;cross immunity;cross reactivity;current pandemic;design;Development;economic impact;Epitopes;Exhibits;Explosion;fighting;flu;Future;Generations;Genetic;Goals;Grant;Herd Immunity;Human;human model;Immunity;Immunologic Memory;Immunology;Infection;Influenza;influenza infection;influenza virus strain;influenza virus vaccine;insight;Intramuscular;Knowledge;Learning;Life;Longevity;Lung;lung development;Lung infections;Lymphocytic choriomeningitis virus;Mediating;Medical;Memory;Middle East Respiratory Syndrome Coronavirus;Modeling;mouse model;Mus;neutralizing antibody;pandemic disease;Pathogenesis;Peptides;peripheral blood;Persons;Phenotype;Plasma Cells;Population;post SARS-CoV-2 infection;Predisposition;pulmonary function;repository;response;Risk Factors;RNA vaccination;RNA vaccine;Role;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 infection;Secondary to;Severe Acute Respiratory Syndrome;Social Distance;Societies;T cell response;T memory cell;T-Lymphocyte;Time;tissue resident memory T cell;Tissues;Transgenic Mice;Vaccinated;Vaccination;vaccine development;vaccine efficacy;Vaccines;Variant;variants of concern;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: The generation and protective function of lung tissue resident memory T cells following SARS-CoV-2 infection or vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The time demands of cancer and its treatments are significant and take away from other activities important to individuals with cancer. Using automated sensor data, we will measure objective cancer-related time use over a 28-day period, augmented by self-reported specific cancer activities, well-being, and quality of life to develop a scoring system of cancer-related time burden among adults with advanced ovarian or metastatic breast cancer. The project will have a positive impact by creating measures of cancer-related objective time use and subjective burden, enabling us to develop and measure the efficacy of future interventions to reduce cancer time demands.

PI_NAMEs: VOGEL, RACHEL ISAKSSON (contact);WOLFSON, JULIAN

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: active method;Address;Adult;Adverse event;Affect;Age;analytical method;Area;Cancer Burden;cancer care;Cancer Patient;Cancer Survivorship;cancer therapy;Caring;Categories;Cellular Phone;Cessation of life;Characteristics;Clinical;cohort;Combined Modality Therapy;Complex;Data;Data Collection;Data Reporting;demographics;Development;Diagnosis;Dimensions;Employment;experience;Face;Family;flexibility;Future;Goals;Health;health care delivery;Health Technology;Healthcare;Healthcare Systems;improved;Individual;innovation;Intervention;Life;Location;Logistics;loss of function;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Metastatic breast cancer;Methods;mHealth;Mobile Health Application;mobile sensing;mobile sensor;Modeling;neglect;novel;Outcome;Ovarian;Participant;Pathway interactions;Patient Self-Report;patient variability;Patients;Personal Satisfaction;Play;Population;premature;Prospective, cohort study;Provider;psychosocial outcome;Quality of life;Recommendation;Reporting;Research;Risk;Role;rural residence;Schedule;sensor;shared decision making;side effect;smartphone application;Source;spatiotemporal;standardize measure;Statistical Methods;System;Testing;therapy design;Time;time use;Toxic effect;Travel;treatment comparison;Treatment Protocols;Variant;Wait Time;Work

PROJECT_TITLE: Time toxicity of cancer: the time demands of cancer-related activities and their impact on well-being and quality of life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Neurocognitive impairment (NCI) in persons living with HIV infection (PWH) is a major public health challenge that is expected to grow as PWH reach older age. This proposal will determine whether women with HIV are more vulnerable to NCI than men with HIV due to greater burden and progression of cerebrovascular injury from increased susceptibility to the effects of CVD risk factors and immune activation. Understanding sex differences in the mechanisms driving the development of NCI in PWH will inform the rational design of clinical trials of preventive and therapeutic strategies optimized by sex.

PI_NAMEs: CHOW, FELICIA C. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;Age;Angiography;antiretroviral therapy;Arteries;Aspirin;Automobile Driving;biological sex;Blood specimen;brain magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cerebrovascular;Cerebrovascular Disorders;cerebrovascular imaging;Cerebrum;Clinical Trials Design;Cognition;Cognitive;Cognitive deficits;cognitive function;Cohort Studies;Data;Development;disability;Disease;Dyslipidemias;Enrollment;Ensure;Event;functional independence;functional loss;Funding;General Population;Health;High Prevalence;HIV;HIV Infections;HIV-associated neurocognitive disorder;human old age (65+);immune activation;Impaired cognition;Individual;Infection;Inflammation;inflammatory marker;Injury;Intervention;Ischemic Stroke;Learning;Link;Measures;Mediating;Memory;men;Microvascular Dysfunction;Modernization;Neurocognitive Deficit;Neuropsychological Tests;Neuropsychology;Observational Study;Participant;Pathogenesis;Pathway interactions;personalized approach;Persons;physical inactivity;Population;Populations at Risk;Postmenopause;Predisposition;Premenopause;Prevalence;prevent;Prevention;Prevention strategy;Preventive Clinical Trial;Primary Prevention;processing speed;prospective;Prospective Studies;Public Health;Quality of life;rational design;Recommendation;Research;Risk;Risk Factors;Risk Reduction;Role;sex;Sex Differences;Source;study population;Testing;The Multicenter AIDS Cohort Study;Therapeutic;United States National Institutes of Health;Vascular remodeling;Viral;Virus Replication;White Matter Disease;Woman;women versus men;Women's Interagency HIV Study;Women's prevalence;Work

PROJECT_TITLE: Sex differences in the contribution of cerebrovascular injury and immune activation to neurocognitive impairment in HIV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-N(02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Understanding why lymphoma patients respond or are resistant to state-of-the-art immune therapies is essential for these approaches to reach their full potential. To understand the impact of immune therapies on direct tumor killing and reactivation of the immune system, we propose to directly visualize in vivo the dynamic interplay of lymphoma B cells with their microenvironments in the spleen of the syngeneic mouse model upon immune therapies by 6- color and longitudinal three-photon microscopy. This study will provide the first direct evidence for the nature of the anti-lymphoma immune response and the manner in which lymphomas evade host immune cells and CAR T cells, allowing us to generate new hypotheses for the design of combination immune therapies.

PI_NAMEs: XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Adult;Affect;Aftercare;Antibodies;Apoptosis;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;blood vessel visualization;Blood Vessels;Bone Marrow;Brain;CAR T cell therapy;CD8B1 gene;Cell Communication;cell motility;Cell Therapy;cell type;Cells;chemotherapy;chimeric antigen receptor T cells;Chronic;Color;data acquisition;design;Detection;detector;effector T cell;epigenetic therapy;EZH2 gene;FDA approved;Fluorescence;Follicular Dendritic Cells;Follicular Lymphoma;Generations;Glass;Goals;Helper-Inducer T-Lymphocyte;Hematopoietic Neoplasms;Human;Image;imaging capabilities;imaging system;Immune;immune activation;Immune response;Immune system;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;Implant;in vivo;in vivo imaging;Individual;inhibitor;intravital imaging;intravital microscopy;Label;large cell Diffuse non-Hodgkin's lymphoma;Lasers;lymph nodes;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant lymphoid neoplasm;Malpighian corpuscles;meter;Methods;Microscopy;Motion;mouse model;Mus;mutant;Nature;neoplastic cell;Optics;Patients;Penetration;Photons;Physiologic pulse;Process;recruit;Regulatory T-Lymphocyte;Reporter;Research;Resistance;Resolution;Respiration;response;restoration;serial imaging;side effect;Signal Transduction;Somatic Mutation;Speed;Spleen;System;T-Lymphocyte;Therapeutic;three photon microscopy;Time;Tissue imaging;Tissues;Transplantation;tumor;Tumor Promotion;two-photon;Visualization

PROJECT_TITLE: Understanding the in vivo impact of immunotherapies in splenic lymphoma by intravital three-photon microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-P(81)S]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative: Worldwide, corneal scars are a leading cause of monocular blindness. Initial wound healing responses can prevent infection but subsequent tissue repair often results in scarring that leads to obstructed vision or blindness. Our proposed research is focused on the molecular underpinnings of a novel anti-scarring target for the cornea.

PI_NAMEs: BERNSTEIN, AUDREY M (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acrylamides;Actins;Acute;Affect;Animals;Anti-Inflammatory Agents;Apoptosis;Appearance;Binding;Biological Assay;Biological Models;Blindness;Bone Marrow;Bundling;Cell Adhesion;Cell Communication;Cell Nucleus;Cell surface;Cells;Chronic;Cicatrix;Coculture Techniques;Collagen;Communication;Complex;Cornea;Corneal Injury;corneal regeneration;corneal scar;Cytoskeleton;Cytosol;Data;Deposition;Development;Encapsulated;Endocytosis;Environment;Equilibrium;Excision;Exhibits;Extracellular Matrix;Family suidae;Fibroblasts;Fibrosis;Flow Cytometry;Foundations;G3BP1 gene;Gel;Genetic Transcription;Goals;Hour;Human;Hydrogels;Immune;immune cell infiltrate;Immunohistochemistry;In Situ Nick-End Labeling;in vivo;Infection;Infection prevention;Injury;Integrin alphaV;Integrins;knock-down;Knockout Mice;Legal patent;Ligation;Macrophage;Mediating;Mediator;Modeling;Molecular;Monocular Blindness;mouse model;Mus;Myofibroblast;novel;Nuclear;Organ Culture Techniques;Oryctolagus cuniculus;Outcome;Pathologic;Pathway interactions;Phase;Phenotype;Play;prevent;Proteins;PTPRC gene;Recycling;Research;response;Role;Signal Transduction;Small Interfering RNA;System;Testing;Therapeutic;therapeutic siRNA;Time;tissue repair;Tissues;TP53 gene;Transforming Growth Factor beta;Trauma;Ubiquitin;ubiquitin isopeptidase;Vision;wound;wound healing

PROJECT_TITLE: THE UBIQUITIN PATHWAY IN CORNEAL SCARRING

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Liver cancer is a deadly form of malignancy with limited treatment options. The proposal seeks to understand the functional roles of mTORC2/AKT, TSC/mTORC1 and FOXO1 cascades during liver tumorigenesis. The study is likely to provide new insight into the signaling pathways in liver tumor development and strong evidence to support the development of therapeutics targeting mTOR and FOXO1 as new treatment strategies for this deadly disease.

PI_NAMEs: CHEN, XIN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Ablation;beta catenin;c-myc Genes;cell growth;Cellular Metabolic Process;CTNNB1 gene;Data;Data Set;Development;Disease;Event;experimental study;FOXO1A gene;FRAP1 gene;genetic approach;Genetic Crosses;Genetic study;Glutamate-Ammonia Ligase;Hepatocarcinogenesis;Heterogeneity;Human;In Vitro;in vivo;innovation;insight;Knockout Mice;liver cancer model;Liver neoplasms;Malignant neoplasm of liver;Malignant Neoplasms;MCL1 gene;Mediating;Modeling;mouse genetics;Multiprotein Complexes;Mus;Mutation;MYC gene;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Pathogenesis;Pathway interactions;Phenotype;Phosphotransferases;PI3K/AKT;precision medicine;prevent;Primary carcinoma of the liver cells;Proto-Oncogene Proteins c-akt;Role;Sampling;Sampling Studies;Signal Pathway;Signal Transduction;Testing;The Cancer Genome Atlas;therapeutic development;therapeutic target;TSC1/2 gene;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins

PROJECT_TITLE: Signaling pathways during hepatocarcinogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because we will use advances in brain imaging and machine learning prognostic modeling to considerably reduce time to diagnosis of learning and behavioral problems and subsequent school readiness. This will allow earlier, more targeted interventions, thereby reducing rates of developmental disorders and school failure. The project is relevant to NINDS’ mission because this approach should yield fundamental knowledge about the most common developmental disorders in children born very preterm.

PI_NAMEs: PARIKH, NEHAL A. (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Academic skills;Acceleration;Adult;Affect;Age;American;Area;Attention;Behavior;Behavioral;Biological;Birth;Brain;brain based;Brain imaging;brain magnetic resonance imaging;Child;Chronic Disease;Clinical;Cognitive;cognitive ability;cognitive function;cohort;Cohort Studies;Collection;Control Groups;Country;Data;design;Development;developmental disease;Diagnosis;Diffuse;Diffusion Magnetic Resonance Imaging;early childhood;Early Diagnosis;Early identification;Early Intervention;Early intervention trials;Emotional;Employment;Enrollment;executive function;extreme prematurity;Face;Failure;Functional impairment;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;high risk;high risk infant;Hospitalization;Impaired cognition;Impairment;Income;Individual;Infant;Inflammation;Informal Social Control;Intervention;Knowledge;language impairment;Learning;Longitudinal Studies;Machine Learning;machine learning model;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Matched Group;Mathematics;Measures;Mediating;Mediator;Mental Health;Meta-Analysis;Mission;Modeling;multidisciplinary;National Institute of Neurological Disorders and Stroke;Neonatal;Neuroanatomy;Neurodevelopmental Impairment;Neuronal Plasticity;neuroprotection;novel;Population;population based;Pregnancy;Premature Birth;Premature Infant;preterm newborn;Prevalence;Problem behavior;prognostic;prognostic model;Public Health;Race;randomized, clinical trials;Readiness;Reading;recruit;Recurrence;Research;Sampling;School-Age Population;Schools;Series;sex;Short-Term Memory;socioeconomics;success;Testing;Therapeutic Intervention;Time;white matter;Work

PROJECT_TITLE: A New Model to Identify Preterm Neonates at High-Risk for Cognitive Impairments and School Readiness

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative We propose to study the delicate balance between two essential types of white blood cells, which provide protection against infection but can also dangerously contribute to inflammatory bowel diseases (IBD). Prior research highlights how the bacteria that peacefully live within our intestines can heavily influence this equilibrium, but the specific conditions that lead to either type of imbalance remain a mystery. Our work to define all the cells and molecules involved in this process will uncover brand-new therapeutic targets to optimally treat IBD while minimizing infectious risk.

PI_NAMEs: LITTMAN, DAN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adopted;Affect;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Autoimmune Diseases;Bacteria;Bone Marrow;candidate identification;CD4 Positive T Lymphocytes;Cell Communication;Cell Differentiation process;Cell Line;Cell Physiology;cell type;Cells;Characteristics;Chimera organism;Chronic;Colon;commensal bacteria;Complement;Cre driver;Crohn's disease;cytokine;Dangerousness;Data;Data Set;Dendritic Cells;Docking;dysbiosis;embryonic stem cell;Endothelial Cells;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;Equilibrium;experimental study;Exposure to;FOXP3 gene;Genetic;Genetic Models;Genetic Predisposition to Disease;Goals;gut inflammation;gut microbiota;Health Benefit;Helicobacter hepaticus;Heterozygote;Histocompatibility Antigens Class II;Homeostasis;Immune system;immunological synapse formation;Impairment;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Integrin alphaV;Interleukin-10;intestinal barrier;intestinal homeostasis;Intestines;intravital microscopy;ITGAX gene;Lamina Propria;Leukocytes;Location;lymph nodes;Lymphoid Cell;Macrophage;Maintenance;Mediating;mesenteric lymph node;MHC Class II Genes;Microbe;microbial;microbiota;microorganism;migration;Modeling;Mouse Strains;multiphoton microscopy;Mus;Mutant Strains Mice;Mutate;Mutation;Myeloid Cells;new therapeutic target;pathobiont;pathogen;Pathogenicity;Pathway interactions;Phenotype;Physiological;Population;Process;programs;Province;receptor;Regulation;Regulatory T-Lymphocyte;Reporter;Research;response;Risk;Role;single-cell RNA sequencing;Sorting;spatiotemporal;Specific qualifier value;Study models;System;T cell differentiation;T cell response;T-Cell Activation;T-Lymphocyte;Therapeutic;transcription factor;transcriptomics;Transforming Growth Factor beta;Transgenic Organisms;Tumor Immunity;Ulcerative Colitis;villin;Work

PROJECT_TITLE: Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiota

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE  Alzheimer’s disease (AD) and other neurodegenerative diseases involve a loss of brain function and brain cells over time and eventually cause death, affecting one third of people over the age of 85. Recent research has found that brain cells build up new mutations in the DNA (known as somatic mutations) as we get older, which appears to harm the brain cells. This proposal will test the hypothesis that somatic mutations contribute in important ways to Alzheimer’s disease, and are related to two other kinds of disease damage in brain cells, oxidative stress and Tau neurofibrillary tangles.

PI_NAMEs: MILLER, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: abeta oligomer;Address;Advisory Committees;Affect;Age;age related neurodegeneration;aged;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Anatomy;Area;area striata;association cortex;Atrophic;Autopsy;Biological;Biomedical Research;Boston;Brain;brain cell;Brain region;burden of illness;career;career development;Cause of Death;cell injury;Cells;cellular pathology;Chromosome Mapping;Clinical;comparison control;Data;Data Analyses;Deposition;Disease;disorder control;DNA;DNA Damage;Etiology;Event;experience;Fellowship;Fluorescence;Functional disorder;Genetic Diseases;Genome;genome sequencing;genome-wide;Genomic approach;Genomics;Hippocampus;Hospitals;Human;Human Genetics;Individual;International;Investigation;Laboratories;large datasets;Link;Measures;medial temporal lobe;medical schools;meetings;Mentors;Mutation;Neoplasms;Nervous System Disorder;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurology;neuron loss;Neurons;neuropathology;next generation sequencing;normal aging;novel;novel sequencing technology;Nuclear;Nucleotides;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pediatric Hospitals;Persons;Physicians;Pilot Projects;Prefrontal Cortex;Privatization;professor;programs;Research;Research Personnel;Residencies;Role;Sampling;Scientist;single cell genomics;Single Nucleotide Polymorphism;Somatic Mutation;Sorting;Staging System;Stereotyping;Structure;tau aggregation;tau Proteins;tau-1;Technology;Testing;Time;Tissues;Training;Training Programs;United States National Institutes of Health;Variant;variant detection;whole genome;Woman;Work

PROJECT_TITLE: Genome-Wide Somatic Mutation in Alzheimer's Disease Pathogenesis Using Single Neuron Analysis

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Public Health Relevance Statement This project seeks to develop a new understanding of how the spinal cord controls motor output through advancement of experimental and statistical approaches by recording the discharge of spinal neuron populations. We will use this approach to better understand acute and chronic changes in the firing of spinal neurons following spinal cord injury. This knowledge will provide new avenues to improve and monitor rehabilitation following neurological injury.

PI_NAMEs: THOMPSON, CHRISTOPHER KEITH (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;advanced analytics;Animal Model;Biological Markers;Brain Stem;Characteristics;Chronic;Clinical;Coupled;Data;Electrodes;Electrophysiology (science);extracellular;Family Felidae;Future;Generations;genetic approach;Human;improved;in vivo;Individual;Injury;innovation;insight;Interneurons;Knowledge;Lesion;Life Change Events;Measures;Mediating;Mental Depression;Microelectrodes;Modeling;Modification;Monitor;Motion;Motor;Motor Activity;motor control;motor function improvement;Motor Neurons;Motor output;Movement;Muscle;Muscle Fibers;Nervous System Trauma;neural;Neurons;neuroregulation;novel;novel strategies;Organizational Change;Outcome;Pathway interactions;Pattern;pharmacologic;Population;Preparation;public health relevance;receptive field;receptor;Reflex action;Rehabilitation therapy;response;Sensory;Serotonin;Source;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord transection injury;spinal shock;Statistical Models;Synapses;Synaptic plasticity;Testing;tool;Work

PROJECT_TITLE: The organization of spinal neurons following spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Chronic non-cancer pain is common among Veterans, and more work is needed to understand how best to support Veterans with chronic pain to improve pain-related function and quality of life. Peer specialists may be valuable resource to support Veterans in pain management. Peer specialists, individuals with lived experience who are hired and trained to work with Veterans, are increasingly being used outside traditional mental health settings. More research is needed to understand how best to train peer specialists to work in new settings and with new presenting problems, such as chronic pain. Peer support to help Veterans improve pain-related function, increase physical activity, and engage in recommended pain care, is especially needed. In this study, we will finalize a peer-led intervention and then pilot it with 24 Veterans with chronic pain in order to establish feasibility and acceptability; results will be used to develop a larger proposal testing our intervention in a randomized trial.

PI_NAMEs: EDMOND, SARA  (contact)

PROJECT_TERMS: acceptability and feasibility;Active Listening;addiction;Address;arm;Behavioral;Caring;Centers for Disease Control and Prevention (U.S.);Certification;Chronic;Chronic Disease;chronic pain;chronic pain management;chronic pain patient;Clinic;Clinical;Clinical Trials;cost;daily functioning;Data;Development;diabetes self-management;disability;Distress;Effectiveness;Elements;Employee;Enrollment;experience;functional improvement;Goals;Guidelines;Healthcare;improved;Individual;innovation;Intervention;intervention mapping;intervention refinement;Lived experience;Manuals;medical appointment;Medicine;meetings;Mental Health;Methodology;motivational enhancement therapy;multidisciplinary;multimodality;non-cancer chronic pain;non-opioid analgesic;Opioid;opioid misuse;opioid overdose;opioid therapy;Outcome;Outcome Measure;Pain;Pain management;pain reduction;pain self-management;pain-related disability;patient engagement;patient navigator;Patients;pedometer;peer;peer support;Persistent pain;Personal Satisfaction;Pharmaceutical Preparations;Physical activity;physical conditioning;pilot test;pilot trial;Primary Care;Prospective Studies;Protocols documentation;Public Health;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;rehabilitation research;Research;research and development;Research Personnel;Resources;Role;Self Management;Services;skills;Specialist;Substance Use Disorder;team-based care;Testing;therapy development;Time;Training;Veterans;Veterans Health Administration;Walking;whole health;Work

PROJECT_TITLE: Pilot of Peers Enhancing Engagement for Pain Services

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This project explores the critical role of myeloid cells and T helper 17 cells (Th17) in maintaining an inflammatory tumor microenvironment in the colon and attempts to address a novel role of neutrophil-derived Interleukin-39 in promoting Th17 development. An improved understanding of the cellular and molecular mechanisms underpinning tumor-promoting inflammation will help design novel therapeutic strategies which could impact the way we treat patients with colorectal cancer and chronic inflammatory disease of the gastrointestinal tract.

PI_NAMEs: CHADHA, AWALPREET SINGH (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;angiogenesis;ARG2 gene;Attenuated;Automobile Driving;Azoxymethane;Cancer Etiology;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Maintenance;Cells;Cessation of life;Chronic;chronic inflammatory disease;Colitis associated colorectal cancer;Colon;colon carcinogenesis;Colonic inflammation;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Complex;cytokine;design;Development;dextran sulfate sodium induced colitis;Digestive System Disorders;Dimerization;Disease;Disease Progression;Event;Family;Feedback;Foundations;Gene Expression;Genes;Growth;gut inflammation;Heterogeneity;Human Herpesvirus 4;IL12B gene;IL17 gene;Immune;Immune checkpoint inhibitor;improved;Incidence;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-12;Interleukins;Intervention;Invaded;ITGAM gene;Kinetics;Link;Macrophage;Maintenance;Mediating;Mediator;Molecular;monocyte;mortality;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neutrophil;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phase;Play;Population;prevent;Process;Production;Prognosis;programmed cell death ligand 1;rational design;recruit;Resistance;response;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Source;synergism;T-Lymphocyte;Testing;Therapeutic;treatment strategy;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;tumorigenic;United States;Vascular Endothelial Growth Factors;Work;γδ T cells

PROJECT_TITLE: Dissecting the Myeloid-Th17 axis in the pathogenesis of Colitis-associated Colorectal Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ARLINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE Leveraging four publicly available large-scale neuroimaging datasets, this project aims to improve personalized early diagnosis and prediction of Alzheimer’s disease (AD) by constructing reliable, corresponding and individualized imaging measures based on brain landmarks and by representing the continuum of AD progression based on these features.

PI_NAMEs: LI, GANG ;ZHU, DAJIANG  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Anatomy;Atlases;biobank;Biology;Brain;brain based;Brain Mapping;Classification;Clinical;cohort;Computational Technique;computerized tools;connectome;cost;Data;Data Set;Data Sources;deep learning;Dementia;Development;disease classification;Disease Progression;Early Diagnosis;flexibility;Functional disorder;Heterogeneity;Hour;Human;Image;image registration;imaging biomarker;imaging study;Impairment;improved;Individual;individual variation;inter-individual variation;large scale data;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;Modeling;Monitor;Multimodal Imaging;multimodality;Nature;neural network;Neurodegenerative Disorders;neuroimaging;normal aging;Pathway interactions;Patients;Pattern;personalized diagnostics;personalized predictions;Phase;Population;pre-clinical;Process;Property;response;Series;Shapes;Structure;Surface;System;Testing;Time;tool;Trees;trend;Work

PROJECT_TITLE: Mapping Trajectories of Alzheimer's Progression via Personalized Brain Anchor-nodes

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Limited detection sensitivity to features prognostic of retinopathy of prematurity progression by conventional diagnostics is the critical barrier to timely clinical intervention. This program aims to develop robust point-of-care hardware and software technologies to improve the current clinical standard-of-care in preterm infants.

PI_NAMEs: OGUZ, IPEK  (contact);TAO, YUANKAI KENNY

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Algorithms;analysis pipeline;Angiography;anterior chamber;Area;awake;Blindness;Blood Vessels;Childhood;Clinical;clinical diagnostics;clinical examination;Clinical Research;clinically relevant;Computer software;Coupled;Custom;Data;Data Set;design;detection limit;detection sensitivity;Development;Devices;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Imaging;Dilatation - action;Ensure;ergonomics;Eye;Eye diseases;feature extraction;Fluorescein;Image;Image Analysis;Image Enhancement;image processing;image registration;imaging platform;imaging system;improved;in vivo imaging;Incidence;Infant;insight;interest;Intervention;kinematics;Manuals;Measures;Morphologic artifacts;Motion;multimodality;neovascularization;novel;Operative Surgical Procedures;Ophthalmology;Ophthalmoscopy;Optical Coherence Tomography;Optics;Outcome;Patients;Performance;Peripheral;pharmacologic;point of care;Premature Infant;prognostic;programs;Protocols documentation;prototype;Quality Control;quantitative imaging;Reproducibility;Research;Resolution;Retina;Retinal Detachment;retinal imaging;Retinopathy of Prematurity;sample fixation;Sampling;serial imaging;Signal Transduction;Source;Speed;Staging;standard of care;structural imaging;System;Technology;Time;tomography;tractography;Translating;Translations;vascular abnormality;Vascular Diseases;Vascularization;Vertebral column;Vision;Visual;Visualization;Weight

PROJECT_TITLE: Point-of-care ophthalmic diagnostic imaging of retinopathy of prematurity


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This study contributes to the National Institute of Aging’s priorities to improve the health of older adults with dementia. Understanding nursing home HIT maturity and care environments where administrators and nurse practitioners work will help us identify methods to unlock their maximum potential to improve quality of care for residents with dementia. With the cooperation of administrators and nurse practitioners, we will identify ways to provide better clinical care for nursing home residents with dementia.

PI_NAMEs: ALEXANDER, GREGORY L. (contact);POGHOSYAN, LUSINE

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Administrator;Alzheimer's disease related dementia;Black race;care coordination;care delivery;care outcomes;Caring;Characteristics;Chronic Disease;Clinical;clinical care;Communication;Data;Dementia;dementia care;Devices;Diagnosis;Discipline;Disparity;disparity reduction;Elderly;Emergency department visit;Engineering;enhanced care;Environment;ethnic health disparity;experience;Health;health assessment;health difference;health disparity;health information technology;Healthcare Systems;high risk;Home Nursing Care;Hospitalization;hospitalization rates;improved;improved outcome;informant;Intervention;Interview;Lead;Leadership;Length of Stay;Link;Long-Term Care Nursing;Mediating;Medicare claim;Medicine;Methods;Minority Groups;multiple chronic conditions;National Institute on Aging;Nurse Practitioners;nursing care quality;nursing home length of stay;Nursing Homes;Nursing Staff;older adult;Outcome;Ownership;Persons;Play;Provider;Quality of Care;Quality of life;racial health disparity;Research;Resources;restraint;Risk;Role;Rural;Supportive care;Surveys;Technology;Testing;Training;trend;Underrepresented Populations;United States;United States National Academy of Sciences;Visiting Nurse;Work

PROJECT_TITLE: Impact of Nursing Home Leadership Care Environments and Health Information Technology on Outcomes of Residents with Alzheimer's Disease and Related Dementias (ADRD)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: EL PASO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

PHR: Project Narrative Tuberculosis (TB) remains a serious disease by causing about 1.4 million deaths annually. BCG is the only vaccine available for TB but this is not effective in preventing pulmonary TB. In this proposal, we propose to develop a better vaccine against TB by genetically modifying BCG.

PI_NAMEs: DHANDAYUTHAPANI, SUBRAMANIAN  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adult;Animal Model;Antibiotics;Antigen Presentation;antigen processing;Antigen-Presenting Cells;Apoptosis;Attenuated;Attenuated Vaccines;Autophagocytosis;BCG Live;BCG Vaccine;C57BL/6 Mouse;Cavia;Cell Culture Techniques;cell mediated immune response;Cells;Cessation of life;Child;Childhood;Dendritic Cells;Disease;DNA;Dose;efficacy evaluation;Ensure;Failure;Gene Deletion;Gene Modified;Generations;Genes;genetic manipulation;genome integrity;genome sequencing;global health;Goals;Health;HIV;HIV Infections;HIV-1;homologous recombination;human morbidity;human mortality;humanized mouse;Immune;Immune response;immune RNA;Immunity;Immunize;Immunocompetent;immunodeficiency;immunogenic;immunogenicity;improved;In Vitro;in vivo;Individual;Infant;infant infection;innovation;Knock-out;knockout gene;Licensing;Lysosomes;Macrophage;Meta-Analysis;Methods;mouse model;Mus;mutant;Mycobacterium bovis;Mycobacterium tuberculosis;novel;Outcome;overexpression;pathogenic bacteria;Persons;Phagosomes;Phase III Clinical Trials;Plasmids;prevent;Preventive;Process;Protein Subunits;Proteins;Pulmonary Tuberculosis;Recombinant Vaccines;Recombinants;Safety;safety assessment;SCID Mice;Spleen;Structure of parenchyma of lung;study population;suicidal;T memory cell;Testing;Time;Tissues;transcriptome sequencing;transcriptomics;Tuberculosis;Tuberculosis Vaccines;vaccine access;vaccine candidate;vaccine trial;Vaccines;Viral Vector;Virulence;Virulent;whole genome

PROJECT_TITLE: A novel hyper-immunogenic low virulent BCG vaccine against tuberculosis

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Our project will define the signaling mechanisms by which Jagged 1 induces osteogenesis using vivo models. Proposed work utilizes approaches that are clinically relevant and will provide important information on when and how Jagged-Notch signaling can be utilized to accelerate bone healing. Results of the proposed studies will provide a better understanding of the role of Notch signaling during bone healing and will evaluate the potential for therapeutic modulation of the healing process.

PI_NAMEs: HANKENSON, KURT DAVID;KALAJZIC, IVO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acceleration;Agonist;BMP2 gene;bone;Bone callus;bone fracture repair;bone healing;Bone Injury;Bone Regeneration;Bypass;Cell Lineage;cell type;Cells;Cephalic;Chondrocytes;Clinical;clinically relevant;Complex;Data;Defect;Development;efficacy evaluation;Endothelial Cells;Endothelium;Ensure;Environment;experience;Femoral Fractures;Femur;Fracture;Gene Expression;Generations;Goals;healing;Histology;Impaired healing;Impairment;improved;in vivo;inducible Cre;Injury;jagged1 protein;Joints;Laboratories;Laboratory Study;Ligands;long bone;LoxP-flanked allele;Mechanics;Mesenchymal Differentiation;Mesenchymal Stem Cells;Modeling;Molecular Analysis;Molecular Target;mouse model;Mus;Natural regeneration;new therapeutic target;notch protein;Notch Signaling Pathway;novel therapeutics;Osteoblasts;Osteocytes;Osteogenesis;Outcome;Periosteum;Play;pre-clinical;preclinical study;Process;Proliferating;promoter;Proteins;Publications;Publishing;receptor;Receptor Inhibition;Regulation;Regulatory Pathway;Research Personnel;Role;Signal Transduction;single cell sequencing;skeletal regeneration;Source;stem cell differentiation;stem cell expansion;stem cell proliferation;Testing;Therapeutic;Time;Tissues;Translating;translational study;Vascularization;Work

PROJECT_TITLE: Notch signaling and Bone Fracture Healing

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Tau pathology causes shrinkage of brain tissue (neurodegeneration) and ultimately cognitive decline in Alzheimer’s disease (AD), but some people have more or less tissue shrinkage than expected for a given level of tau in specific brain regions. This project will study the regional patterns of this “mismatch” between pathology and brain damage as a tool to categorize people who may be more vulnerable to decline due to other underlying conditions or more resilient to brain damage. This approach may ultimately help improve clinical management, make drug trials more efficient, and enhance understanding of the heterogeneity in AD.

PI_NAMEs: DAS, SANDHITSU  (contact);WOLK, DAVID A

PROJECT_TERMS: Affect;Age;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Apolipoprotein E;Atrophic;Autopsy;Biological;Biological Markers;Brain;Brain Injuries;Brain region;brain tissue;Categories;Classification;Clinical;Clinical Management;clinical phenotype;Cognition;Cognitive;cognitive performance;cohort;Collection;comorbidity;convolutional neural network;Data;Data Set;Demographic Factors;digital;Dissociation;Evaluation;Functional disorder;Future;Gender;Genotype;gray matter;Heterogeneity;Histopathology;Image;imaging modality;Impaired cognition;improved;in vivo;in vivo imaging;Individual;Institution;Life;Linear Regressions;Magnetic Resonance Imaging;Measures;Mediating;Methods;Modeling;Multimodal Imaging;multimodality;multiple datasets;Nerve Degeneration;Neuroanatomy;Neurofibrillary Tangles;Outcome;Pathologic;Pathology;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;Process;protein TDP-43;regional atrophy;Research;Residual state;resilience;Risk Factors;Sampling;Senile Plaques;sex;Source;Specimen;statistical and machine learning;Subgroup;tau aggregation;tau Proteins;Techniques;Testing;Thick;Tissues;tool;Variant;Vascular Diseases;vascular risk factor;Vulnerable Populations;White Matter Hyperintensity

PROJECT_TITLE: Characterization of relationship between tau pathology and neurodegeneration in Alzheimer's disease using multimodal imaging


NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE: Urinary tract infections (UTIs) and specifically catheter-associated UTIs (CAUTIs) and stent infections pose increasing problems for treatments due to increasing antibiotic resistance. Further, catheter and stent- associated infection management is complicated by the polymicrobial nature of these infections. This proposal aims to greatly increase our clinical knowledge and understanding of mechanisms by which polymicrobial communities form on urinary medical devices, direct same-day antimicrobial resistance (AMR) gene profiling to improve antibiotic stewardship and develop antibiotic-sparing treatment therapies.

PI_NAMEs: CAPARON, MICHAEL G.;HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acinetobacter;Address;Affect;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;Antimicrobial Resistance;Binding;Biology;Bladder;catheter associated UTI;Catheterization;Catheters;Clinic;Clinical;Clinical Research;Clinical Treatment;Collection;Communities;Data;Detection;Deterioration;Development;Devices;Diagnosis;Disease;Disease Outcome;Enterococcus;Escherichia;Escherichia coli Adhesins;Excision;Fibrinogen;Foreign Bodies;Foundations;Functional disorder;Generations;Genomics;Genus staphylococcus;Growth;Habitats;Health Care Costs;Hospitals;Hour;Human;Immune response;Immunotherapy;Implant;improved;In Vitro;in vitro Model;Indwelling Catheter;Infection;infection management;insight;Klebsiella;Knowledge;Ligands;Lower urinary tract;Mannosides;Measures;Medical Device;member;metagenomic sequencing;Microbial Biofilms;microbial community;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;nanopore;Nature;novel therapeutic intervention;Organism;pathogenic bacteria;Pathogenicity;Patients;Phase;Phase II Clinical Trials;polymicrobial biofilm;polymicrobial disease;Predisposition;Prevalence;Proteins;Quality of life;Recurrence;resilience;resistance gene;Resistance profile;Risk;sample collection;Sampling;small molecule inhibitor;small molecule therapeutics;Stents;Stress;symptomatology;Symptoms;Technology;Testing;Therapeutic;therapy development;Third Generation Sequencing;Time;Treatment Efficacy;treatment guidelines;treatment strategy;urinary;Urinary tract;Urinary tract infection;urolithiasis;Uropathogen;Vaccines;Work;wound

PROJECT_TITLE: Impact of Foreign Bodies on Infection Susceptibility, Disease and Mucosal Remodeling of the Urinary Tract

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Lyme disease is the most common arthropod-borne illness in the United States. The causative agent, Borrelia burgdorferi, maintains itself in nature through a complex tick-mammal life cycle involving an Ixodes tick vector and mammalian hosts. This study will elucidate molecular components critical for the maintenance of the infectious cycle of B. burgdorferi, which will provide new modalities for the development of innovative disease intervention strategies.

PI_NAMEs: OUYANG, ZHIMING  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;antimicrobial;arthropod-borne;Arthropods;Bacteria;Bacteria sigma factor KatF protein;bacterial fitness;Binding;Biochemical;Biological;Borrelia burgdorferi;Borrelia oxidative stress regulator;Candidate Disease Gene;Chromosomes;cohort;Complex;Coupled;Data;Defect;Development;Disease;disorder prevention;Disparate;enhancer binding protein;environmental adaptation;enzootic;Etiology;expectation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Growth;Homologous Gene;imaging approach;In Vitro;in vivo;Infection;innovation;Intervention;Ixodes;Knowledge;Life Cycle Stages;Location;Lyme Disease;Maintenance;Mammals;Mediating;metabolome;Modality;Molecular;Mus;mutant;Nature;novel;novel vaccines;Operon;Order Spirochaetales;outer surface lipoprotein;Pathogenicity;Pathway interactions;Phase;Phenotype;Plasmids;Play;posttranscriptional;prevent;Promoter Regions;Proteins;Proteome;Regulation;Regulatory Pathway;Regulon;Repression;Role;Ticks;trait;transcriptome;transcriptome sequencing;transcriptomics;transmission process;United States;vector;vector tick;Vector-transmitted infectious disease;Virulence;virulence gene;Work

PROJECT_TITLE: Virulence regulation by BadR in the Lyme disease spirochete

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]