ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Project Narrative This proposal seeks to define new regimens of drugs at optimal dose combinations to cure pulmonary Mycobacterium avium complex (MAC) infections for which current therapeutic regimens are empirical and clinical trial evidence to guide precision dosing is lacking. When causing the disease, MAC pathogens are inside the cells, thus, we selected the drugs for this proposal based on their ability to penetrate and accumulate inside cells, thereby effectively killing the MAC in relatively less time compared to the current guideline-based combination regimen. Since the safety and toxicity profile of the proposed drugs in humans is well documented, the new short-course regimens could be quickly advanced into clinics for the treatment of MAC pulmonary disease.

PI_NAMEs: KANT, SHASHI  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Accounting;American;antagonist;Antibiotics;Applications Grants;appropriate dose;Bacteria;bench-to-bedside translation;beta-Lactams;Biological;Biological Models;Blood specimen;Cells;Chest;Chronic;Clinic;Clinical;Clinical Data;Clinical Trials;Combined Modality Therapy;Containment;Data;design;Disease;Disease Progression;Dose;Drug Combinations;Drug Exposure;Drug Kinetics;drug repurposing;Drug resistance;Drug Screening;efficacy validation;Ethambutol;Etiology;evidence base;experience;experimental study;Extinction;extracellular;Fiber;genome sequencing;Growth;Guidelines;Human;Immune;in silico;In Vitro;in vivo;Incidence;Infection;Knowledge;Laboratories;Left;Lung;Lung Diseases;Macrolides;Mathematics;Meta-Analysis;Minimum Inhibitory Concentration measurement;Modeling;Monte Carlo Method;mouse model;Mus;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium intracellulare;Mycobacterium kansasii;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;optimal treatments;Outcome;Oxazolidinones;Parameter Estimation;pathogen;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacodynamics;Population;pre-clinical;Pre-Clinical Model;Predisposition;Prevalence;prospective;Public Health;Recommendation;Regimen;Relapse;Resistance;response;Rifamycins;Role;Safety;simulation;Societies;Sputum;standard of care;Surface;synergism;System;Tetracyclines;Therapeutic;therapy duration;Time;Tissue Sample;Tissues;Toxic effect;Translating;Treatment Protocols;Uncertainty;whole genome

PROJECT_TITLE: Short course combination regimens for treatment of Mycobacterium avium pulmonary disease: a translational bench-to-bedside approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: LEBANON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Project Narrative Metoidioplasty and Phalloplasty Gender Affirming Surgeries (MaPGAS) are complex, high risk procedures that require patients to make several decisions affecting long term gender congruence, fertility, urinary and sexual health. Many patients considering MaPGAS have decisional uncertainty without access to validated decision support which limits the quality of shared decision making, potentially leading to poor quality decisions and unexpected outcomes. The purpose of this study is to 1) evaluate the usability, acceptability, and 2) preliminary efficacy of a novel, community developed web based MaPGAS decision aid designed to reduce decisional uncertainty, improve decision readiness, and facilitate quality MaPGAS shared decision making.

PI_NAMEs: MOSES, RACHEL A (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Address;Affect;assigned female at birth;Clinical;Collaborations;Communities;Complex;Conflict (Psychology);Consensus;Consult;Consultations;cost;Counseling;Coupled;Decision Aid;Decision Making;design;Emotional;empowerment;Equipoise;Evaluation;experience;feasibility testing;Feedback;Fertility;Fistula;Focus Groups;Future;Gender;Gender Confirmation Surgery;Genitalia;Geography;Goals;Guidelines;Health;health literacy;high risk;improved;Individual;infection risk;Institution;Interview;Location;Measures;member;Methods;metoidioplasty;nonbinary;novel;Online Systems;Operative Surgical Procedures;Outcome;Participant;patient oriented;Patient Recruitments;patient retention;Patients;penis;phalloplasty;Phase;pilot trial;Population Heterogeneity;preference;Preparation;primary outcome;Procedures;prospective;Prospective Studies;Prosthesis;prototype;Provider;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Recovery;recruit;Reporting;reproductive organ;Research Design;Review Literature;Risk;Sampling;secondary outcome;Sex Functioning;Sexual and Gender Minorities;Sexual Health;shared decision making;Site;Skin;social;Staging;Structure;support tools;Surgeon;surgery outcome;surgical risk;System;systematic review;Testing;Testis;Time;Tissues;tool;transgender;Trauma;Travel;treatment as usual;Uncertainty;United States;Urethra;Urethral Stricture;urinary;Urination;usability;Work

PROJECT_TITLE: Decision Making in Metoidioplasty and Phalloplasty Gender Affirming Surgery (MaPGAS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WASHINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  Myocardial infarction is a leading cause of morbidity and mortality worldwide. Due to the limited regenerative capacity of cardiac tissues, many challenges remain in generating human myocardial tissue. This project will develop an effective and readily available biomanufacturing method that will have a significant impact on treating myocardial infarction and other related cardiovascular diseases.

PI_NAMEs: MOHIUDDIN, MUHAMMAD M;ZHANG, LIJIE GRACE (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Adult;Anatomy;Angiography;Animal Model;Architecture;Awareness;Behavior;Biocompatible Materials;Biological;Biomanufacturing;biomaterial compatibility;Biomechanics;Biomedical Engineering;Biomimetics;bioprinting;Bioreactors;Bone Tissue;carcinogenicity;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cell Physiology;Cell Survival;Cells;Cessation of life;Characteristics;Chronic;Clinical;Clinical Engineering;clinically relevant;Complex;design;Diameter;Dimensions;Echocardiography;economic outcome;Emotional;Endothelial Cells;Endothelium;Engineering;Engraftment;Evaluation;Event;Exhibits;experimental study;fabrication;Family suidae;Fiber;Fibroblasts;fighting;fundamental research;Gelatin;Geometry;healing;Health;Heart;heart damage;Heart failure;heart function;Heart Injuries;hemodynamics;Histology;Hospitals;Human;Human Engineering;human induced pluripotent stem cells;Hydrogels;Immunohistochemistry;Implant;implantation;improved;In Situ;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Infarction;Injury;innovation;Investigation;manufacture;Mechanical Stimulation;Mechanics;Medical;Metabolic;Methods;Microcirculation;Modeling;Morbidity - disease rate;mortality;Mus;Myocardial;myocardial damage;Myocardial Infarction;myocardial injury;Myocardial tissue;Myocardium;Natural regeneration;novel;novel therapeutics;Nutrient;organ regeneration;Oxygen;Pain;Patients;Pattern;Performance;Periodicity;Permeability;Physiological;Prevention;Printing;Publishing;Regenerative capacity;Regenerative engineering;Regenerative Medicine;repaired;Research;response;restoration;scale up;Science;Smooth Muscle;Smooth Muscle Myocytes;stem;stem cell technology;Stretching;sudden cardiac death;Support System;Techniques;Technology;Therapeutic;Thick;Thinness;Tissue constructs;Tissue Engineering;Tissue Model;Tissues;Vascular blood supply;Vascular remodeling;Vascularization;Ventricular Remodeling;Work

PROJECT_TITLE: A dual 3D bioprinting platform for engineering a thick anisotropic myocardial tissue with geometric vasculature

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-D (02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Drosophila is an important model organism used extensively in evolutionary and developmental biology studies. Drosophila research laboratories often maintain hundreds to thousands of genetically modified stocks, requiring routine maintenance and risk of strain loss or genetic drift. The goal of this project is to develop autonomous cryopreservation methods for Drosophila, such that strains can be banked indefinitely and available for on- demand use.

PI_NAMEs: SANDLIN, REBECCA  (contact);TONER, MEHMET ;WHITE, KRISTIN

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Automated technology for the preservation of Drosophila embryos

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Despite the eradication of smallpox, members of the poxviridae family remain Category A Priority Pathogens and pandemic threats while others are used as oncolytic therapeutics and vaccine vectors. With their unusual level of self-sufficiency and cytoplasmic mode of DNA replication, mechanisms of host sensing and poxvirus evasion strategies are highly complex, and many outstanding questions remain. This proposal explores a unique strategy whereby poxviruses dysregulate the activity of the metabolic sensor and effector kinase, mTOR, to counteract poorly understood aspects of innate responses to infection.

PI_NAMEs: SHEN, PETER ;WALSH, DEREK  (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: aerobic glycolysis;African Swine Fever Virus;Agonist;antagonist;Anti-viral Response;Antigen-Antibody Complex;Binding;Biogenesis;Category A pathogen;cell type;Cells;Cellular biology;Citric Acid Cycle;Co-Immunoprecipitations;Complex;Cryoelectron Microscopy;Cytoplasm;Data;Detection;Disease Outbreaks;DNA;DNA biosynthesis;DNA Viruses;domain mapping;Emergency Situation;Equilibrium;Family;Family member;fatty acid oxidation;FRAP1 gene;Frequencies;Gene Expression;Genes;genetic regulatory protein;Genetic Transcription;Glycolysis;Human;Immune;Immune Evasion;Immune response;Immunology;Infection;insight;Interferons;Mass Spectrum Analysis;Mediating;Medical;member;Messenger RNA;Metabolic;Metabolic Pathway;Mitochondria;Mitochondrial DNA;Modeling;Molluscum Contagiosum;Monkeypox;Monkeypox virus;mRNA Translation;mutant;N-terminal;Nature;novel;Oncolytic;pandemic potential;Pathway interactions;Phosphorylation;Phosphotransferases;Poxviridae;Poxviridae Infections;prevent;Process;Production;protein function;Proteins;Pyruvate;Recording of previous events;Repression;Research;Research Proposals;response;Role;screening;sensor;Signal Transduction;Site;Smallpox;smallpox eradication;Structural Protein;Testing;Therapeutic;vector vaccine;Viral;viral detection;viral DNA;Viral Proteins;Virus;Virus Replication;Zoonoses

PROJECT_TITLE: The role of mTOR dysregulation in poxvirus infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: PATHOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The effective causative therapies for Alzheimer’s Disease (AD) and related dementias associated with Frontotemporal Lobar Degeneration disorders (FTLDs) remain elusive as the patients are often diagnosed at an advanced disease stage. Non-coding RNAs, including those longer than 200 nucleotides referred to as long- noncoding RNAs (lncRNAs), have recently emerged as key regulators of brain functions derailed in AD and FTLDs. The unprecedented combination of human postmortem brain tissue and plasma samples from cross- sectional and longitudinal epidemiologic studies, Alzheimer’s Disease Neuroimaging Initiative, Framingham Heart Study, and Germany’s cognitive impairment and dementia studies, enables us to study lncRNA expression in human cortex, perform functional studies of disease lncRNA biomarker candidates in experimental models, and determine if brain disease lncRNA biomarker candidates may be found in plasma as specific biomarkers for AD and FTLDs permitting subsequent testing of stratified therapeutic approaches in future studies.

PI_NAMEs: BLUSZTAJN, JAN KRZYSZTOF;DELALLE, IVANA  (contact);FISCHER, ANDRE

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Adult;advanced disease;Affect;Age Years;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Astrocytes;Autopsy;biobank;Biological Markers;Biological Models;Blood;Brain;brain cell;Brain Diseases;brain tissue;candidate marker;cell cortex;Cell Physiology;cell type;Cells;Circulation;Clinical;Clinical Research;Cognitive;comparison control;Data;Data Set;Dementia;Diagnosis;diagnostic criteria;diagnostic development;diagnostic tool;Differential Diagnosis;differential expression;Disease;Drug Targeting;early detection biomarkers;Early Diagnosis;effective therapy;Elderly;epidemiology study;Experimental Models;experimental study;extracellular;Formalin;Framingham Heart Study;Freezing;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Future;Genetic Transcription;Genome;German population;Germany;Hippocampus;Human;Human Genome;human induced pluripotent stem cells;Impaired cognition;improved;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;inhibitor;Knowledge;Lasers;liquid biopsy;Materials Testing;Measures;meetings;Methodology;Methods;MicroRNAs;microvesicles;molecular pathology;mouse model;Mus;nanoparticle;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroimaging;neuroinflammation;Neurons;neuropathology;novel;Nucleotides;Paraffin Embedding;Participant;Pathology;Patient-Focused Outcomes;Patients;Pattern;Pilot Projects;Plasma;Population;Prefrontal Cortex;Process;Proteins;Protocols documentation;Report (document);Research;RNA;Role;Sampling;single nucleus RNA-sequencing;specific biomarkers;Specificity;Structure;Syndrome;Techniques;Testing;therapeutic biomarker;therapeutic target;Tissues;tool;trait;treatment stratification;Untranslated RNA;Virion

PROJECT_TITLE: Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  T cells engineered to express chimeric antigen receptors (CARs) can cure some patients with B cell cancers but have failed to meet their potential of widespread efficacy. In this proposal we aim to elucidate how a core CAR functional domain that normally supports T cell function can instead drive a novel form of T cell failure when persistently activated. We further evaluate genome engineering strategies to overcome this failure, with the goal of developing more effective CAR-based therapies that can cure more patients.

PI_NAMEs: SINGH, NATHAN  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Atlases;B-Cell Leukemia;B-Lymphocytes;Biochemical;cancer cell;cancer immunotherapy;CD19 gene;CD28 gene;Cell Death;Cell Lineage;Cell Nucleus;Cell Physiology;Cell Separation;Cell Therapy;Cells;cellular engineering;Cellular immunotherapy;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;clinical application;Cytoplasm;cytotoxicity;Data;Development;Disease Progression;Disease remission;disorder control;effective therapy;effector T cell;engineered T cells;Engineering;Epigenetic Process;Evolution;exhaust;exhaustion;extended reality;Failure;FDA approved;FOXO3A gene;Functional disorder;Gene Expression Profile;Genes;Genetic Transcription;Genome engineering;Goals;Immune response;Immunocompetent;immunodeficiency;improved;In Vitro;in vivo;inhibitor;insight;leukemia;leukemia/lymphoma;link protein;Literature;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Microscopy;Molecular;mouse model;Mutagenesis;mutant;Mutation;novel;Outcome;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;programs;receptor;Receptor Activation;Regulatory T-Lymphocyte;repository;Research;Resistance;Resolution;Sampling;segregation;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Small Interfering RNA;success;Surface;synthetic protein;System;T cell differentiation;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;transcription factor;tumor;Tumor Antigens;Virus Diseases

PROJECT_TITLE: Decoding 41BB-specific dysfunction programs in cellular immunotherapies for cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


PHR: Project Narrative The proposed research is relevant to public health because IgE antibodies that recognize innocuous environmental, food, or insect proteins cause allergic diseases that affect more than twenty percent of the world’s population. Although little is known regarding the role of sugars attached to IgE our preliminary data suggests these sugars play important roles in IgE biology. This project is relevant to the mission of NIH because it will generate basic immunology knowledge relating to the role of the sugars in relating IgE-mediated inflammation, and will establish IgE-related sugars as novel biomarkers and therapeutic targets for allergic disease.

PI_NAMEs: ANTHONY, ROBERT MCCULLOUGH (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adult;Affect;Affinity;Allergens;Allergic;Allergic Disease;Allergic inflammation;Anaphylaxis;anti-IgE;Antibodies;arm;Attenuated;attenuation;Basophils;Binding;Biochemistry;Biological Markers;Biology;biomarker discovery;Biophysics;Cell Count;Cellular Immunology;Clinical;Co-Immunoprecipitations;Complex;crosslink;Data;Disease;Engineering;Epitopes;Excision;experimental study;Food;Food Hypersensitivity;Gene Expression Profile;Genetic Screening;Glycobiology;Glycoengineering;Glycoproteins;glycosylation;Goals;helminth infection;human model;Hypersensitivity;IgE;Immune response;Immunoglobulin G;Immunology;In Vitro;in vivo;Individual;Inflammation;Insect Proteins;Knowledge;Link;Mass Spectrum Analysis;mast cell;Mediating;Mediator;Mission;Modeling;Molecular Immunology;mouse model;Neuraminidase;new therapeutic target;novel;novel marker;Outcome;Pathogenicity;Pathway interactions;Pattern;Play;Polysaccharides;Population;Public Health;receptor;Regulation;Regulatory Pathway;Research;Role;Sialic Acids;sialylation;Signal Pathway;Signal Transduction;Site;Structure;sugar;Symptoms;Systemic Lupus Erythematosus;Testing;Therapeutic;translational impact;United States National Institutes of Health;Writing

PROJECT_TITLE: Non-Templated Regulation of IgE Mediated Anaphylaxis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dissemination and Implementation Research;Nutrition;Patient Safety;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Type 1 diabetes affects more than 8 million people worldwide, shortens lifespan by an average of 10 years, and increases the risk of all ten leading causes of death in the United States. Despite strong evidence that tight control of blood sugar reduces the risk of diabetes complications, most people with type 1 diabetes do not achieve recommended blood sugar targets. This randomized controlled trial will test whether a very-low- carbohydrate ketogenic diet can effectively and safely improve blood sugar control in adults with type 1 diabetes.

PI_NAMEs: KLEIN, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Acute;Address;Adherence;Adipose tissue;Adult;Affect;American;Apolipoproteins B;Artificial Pancreas;autoimmune pathogenesis;Behavioral;Beta Cell;Biochemistry;Blood Glucose;Body Composition;Body Weight;Bone Density;bone health;bone turnover;C-terminal type I collagen telopeptide;Calcium;Carbohydrates;Carbon Dioxide;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Case Series;Cause of Death;Child;Cholesterol;Chronic;clinical efficacy;Complications of Diabetes Mellitus;Consumption;cost;Creatinine;Cyclophosphamide;Dependence;Development;Devices;diabetes distress;Diabetes Mellitus;Diabetic Ketoacidosis;Diet therapy;dietary adherence;Dietary Carbohydrates;dietary control;Dietitian;Dual-Energy X-Ray Absorptiometry;Dyslipidemias;Eating Behavior;Education;efficacy evaluation;Electrolytes;Event;evidence based guidelines;Fatty acid glycerol esters;Femur;Food;food craving;Glomerular Filtration Rate;Glucagon;Glucose;Glucose Clamp;glycemic control;Glycosylated hemoglobin A;Health;Hepatic;High Density Lipoproteins;Hip region structure;Hour;Hybrids;Hyperglycemia;Hyperinsulinism;Hypoglycemia;Iatrogenesis;Impairment;implementation outcomes;improved;improved outcome;Incidence;inflammatory marker;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intake;interest;Interleukin-6;Interview;Intra-abdominal;intrahepatic;ketogenic diet;Ketone Bodies;Ketones;Ketosis;Knowledge;Life Expectancy;life span;Life Style;lipid biosynthesis;Lipids;Lipoproteins;Liver;Low-Density Lipoproteins;Measures;medical attention;medical schools;Metabolic;Methods;Monitor;N-terminal;Neck;novel therapeutics;nutrition;Observational Study;Osteocalcin;particle;Patients;Peripheral;Persons;Plasma;Plasminogen Activator Inhibitor 1;post gamma-globulins;Preparation;Prevalence;primary outcome;Procedures;Procollagen;Quality of life;Questionnaires;Randomized, Controlled Trials;Recommendation;Records;Renal function;Research Institute;Risk;Risk Reduction;Safety;safety assessment;Serum;Site;social;Social Behavior;social determinants;sociodemographic factors;subcutaneous;Surveys;System;Technology;Testing;Thinness;Time;TNF gene;Triglycerides;United States;Universities;Uric Acid;Urine;Vertebral column;Washington

PROJECT_TITLE: EFFICACY AND SAFETY OF A KETOGENIC DIET IN TYPE 1 DIABETES

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Sudden Unexpected Deaths in Infants (SUDI) is a leading cause of preventable infant mortality and yet it has been left largely under addressed in low- and middle-income countries. Project Chisoni seeks to address this knowledge gap by 1) estimating the burden of SUDI in Zambia and (2) evaluating the prevalence of its proximate modifiable risk factors.

PI_NAMEs: HERLIHY, JULIE MORIARTY (contact);SOMWE, SOMWE WA

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accidents;Address;adjudication;Africa;African;Age;Alcohol consumption;Asphyxia;Assessment tool;Autopsy;Back to Sleep;Beds;Biopsy;Birth Weight;Blood;Brain;Bundling;Caring;Cause of Death;Cessation of life;Child;Childhood;Communicable Diseases;Communities;Community Health;Country;Data;Death Rate;Demographic and Health Surveys;Demography;design;Enrollment;Epidemiology;Evaluation;experience;Face;Family;Future;genetic analysis;genetic risk factor;global health;Goals;Grief reaction;Health;Heart;HIV;Income;Infant;Infant Mortality;Intervention;Interview;Investigation;Knowledge;Left;Live Birth;Liver;low and middle-income countries;Lung;Matched Case-Control Study;Measures;Medical;Methods;minimally invasive;modifiable risk;Molecular Biology;mortality;Mothers;multidisciplinary;Neighborhoods;novel strategies;Odds Ratio;Parents;pathogen;Pathology;Pediatrics;Physical Examination;Policies;Population;Population Attributable Risks;premature;Prevalence;Process;Public Health;Recording of previous events;Reporting;Research;Respiratory syncytial virus;Risk Factors;rural setting;screening;Series;sex;Side;Sleep;sleep behavior;sleep position;Smoke;Societies;South Africa;Structure;Subcategory;substance use;Sudden infant death syndrome;Surface;Surveys;systematic review;Time;Tissue Sample;Tissues;tool;trend;ultrasound;urban setting;verbal;Well Child Visits;Zambia

PROJECT_TITLE: Project Chisoni: a study to define the burden of SUDI and its modifiable risk factors in Zambia and other African countries

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Clinicians rely on pulse oximeters to non-invasively estimate oxygen levels in the blood, which is a key piece of data used for diagnosis and treatment of sick children. Studies in adults indicate that pulse oximeters may be less accurate in people with dark skin color, and we therefore seek to investigate how accurate pulse oximeters are in children with different skin colors. Ensuring pulse oximeter accuracy across skin colors is essential for effective and equitable care and the findings of this study will be widely relevant to the millions of children who seek healthcare each year.

PI_NAMEs: O'BYRNE, MICHAEL L;RUPPEL, HALLEY  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: 18 year old;absorption;Accident and Emergency department;Address;Admission activity;Adult;Advisory Committees;Age;age difference;Anesthesiology;black patient;Black Populations;Black race;Blood;Cardiac;Cardiac Catheterization Procedures;Cardiology;Caring;Caucasians;Characteristics;Child;Child health care;Childhood;Clinical;clinical decision-making;Clinical Research;Colorimetry;Critical Care;Darkness;Data;density;Diagnosis;disparity reduction;Electronic Health Record;Ensure;epidemiology study;Equity;Evaluation;Foundations;General Anesthesia;Health;health inequalities;Healthcare;Heart Diseases;Hospitalization;Hypoxemia;improved;indexing;Industry;Inequity;Intensive Care;Intensive Care Units;Intervention;Knowledge;Light;light emission;Link;Literature;Lung Diseases;Manufacturer;Marketing;Measurement;Measures;Mediating;Medical Device;Medical Records;Melanins;Methods;Monitor;Morphologic artifacts;Motion;National Heart, Lung, and Blood Institute;non-invasive monitor;Observational Study;Outcome;Oxygen;Participant;Patients;Pediatrics;Perfusion;Peripheral;Persons;Physiologic pulse;Policies;Population;Positioning Attribute;Procedures;prospective;Pulse Oximetry;Race;Recommendation;Reduce health disparities;Reference Standards;Research;Research Design;routine care;Secondary to;Sedation procedure;sex;Site;Skin;skin color;Source;supplemental oxygen;Testing;Thick;treatment and outcome;treatment disparity;Uncertainty;United States Food and Drug Administration;Voice;volunteer

PROJECT_TITLE: Evaluating the relationship between skin color and pulse oximeter accuracy in children

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because inhibitors of human DNA methyltransferases (DNMT3A/3B) have therapeutic potential for cancer and other diseases. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge for ultimately protecting and improving health.

PI_NAMEs: CHEN, TAIPING ;CHENG, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Aberrant DNA Methylation;Acute Myelocytic Leukemia;analog;anti-cancer;Applications Grants;Azacitidine;Base Pairing;Basic Science;Biochemical;Biological Assay;biophysical properties;Breast Epithelial Cells;cancer cell;Cancer cell line;Cancer Center;Cancer Patient;cancer therapy;Catalytic Domain;Cell Death Induction;cell growth;Cell Line;chemical group;Chemicals;Chromatin Structure;Chronic Myelomonocytic Leukemia;Collaborations;Complex;CpG dinucleotide;Crystallization;Cytidine;Cytosine;cytotoxicity;Dacogen;Data;Decitabine;demethylation;Deoxycytidine;design;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNMT3a;DNMT3B gene;Dysmyelopoietic Syndromes;Embryo;Enzymes;Epigenetic Process;Exhibits;Family;FDA approved;Fibroblasts;Follow-Up Studies;Gene Expression;Gene Silencing;Goals;Health;Hematologic Neoplasms;Human;human DNA;Hypermethylation;improved;in vitro activity;inhibitor;intercalation;Knockout Mice;Knowledge;Laboratories;Lead;Maintenance;Malignant Neoplasms;mammalian genome;Mediating;Methylation;methylation pattern;Methyltransferase;Mission;Modification;Mouse Embryonic Stem Cells;Mus;Mutation;novel;nucleoside analog;Oncogenic;Pattern;preclinical study;Proliferating;Public Health;public health relevance;quinoline;Regulation;Reporting;Research;Solid Neoplasm;System;Testing;Therapeutic;Toxic effect;Transfection;Tumor Suppressor Genes;United States National Institutes of Health;Vidaza;Work

PROJECT_TITLE: Preclinical studies of non-nucleoside DNMT3A/3B inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (O1)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE We have made a number of unexpected observations regarding vitamin A storage and metabolism in important cells within the adult lungs and its critical role in maintaining lung health. The studies being proposed in this application are paradigm-shifting for understanding the mechanisms of how local vitamin A stores are acquired, redistributed and processed among the cells, and how these are understood by the research field. The outcomes of these studies will impact the current strategies, including nutritional interventions, aimed at alleviating lung disease.

PI_NAMEs: SHMARAKOV, IGOR  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute Lung Injury;Address;Adult;adverse outcome;Agonist;All-Trans-Retinol;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar wall;Alveolus;Animals;antagonist;Binding;Buffers;Capillary Endothelial Cell;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;Circulation;Coculture Techniques;Coupled;Data;Diet;Dietary Intervention;Disease;Dominant Negative Receptor;Endothelial Cells;Endothelium;Epithelial Cells;Esters;Exposure to;Extrahepatic;Fluorescence;Genes;Genetic;Genetic Transcription;Health;Hepatic;Hepatic Tissue;Homeostasis;Human;Impairment;in vivo;Inflammatory;interstitial cell;Kinetics;Label;LDL-Receptor Related Protein 1;lipidomics;Lipids;Lipoprotein (a);lipoprotein lipase;Lipoproteins;Liver;Lung;lung development;Lung Diseases;lung health;Maps;Mediating;Metabolic;Metabolism;Molecular;Molecular Profiling;mouse model;Mus;Natural regeneration;novel;Nuclear;Nuclear Hormone Receptors;Nutritional;Outcome Study;Pathway interactions;pharmacologic;Phenotype;Population;postnatal;prenatal;Process;Production;Proteins;pulmonary function;RBP4 gene;Research;Resolution;response;Retinoic Acid Receptor;retinoic acid receptor alpha;Retinoids;Rodent;Role;Signal Transduction;single-cell RNA sequencing;Stimulus;Structure of parenchyma of lung;Study models;surfactant;surfactant production;Tissues;Tracer;trafficking;Transcriptional Regulation;Tretinoin;uptake;Vitamin A

PROJECT_TITLE: Vitamin A metabolism in the adult lung

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Major musculoskeletal trauma, such as volumetric muscle loss (VML), requires advanced regenerative therapies capable of bulk muscle tissue replacement while promoting myogenesis and neurovascular integration. We are advancing the first pre-innervated three-dimensional Tissue Engineered Motor Units (3D-TEMUs) comprising dense centimeter-scale bundles of fascicle-like, aligned myofibers fabricated through the guided self-assembly of human induced-pluripotent stem cell derived skeletal myocytes with axonal inputs from discrete pools of motor neurons. This project will advance the fields of muscle biology and bioengineering by validating a new class of 3D engineered composite soft tissue capable of serving as a biofidelic testbed to study neuromuscular development as well as an implantable substrate to replace lost muscle and augment regeneration following VML.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Actins;Acute;Advanced Development;Afferent Neurons;alpha Bungarotoxin;Anatomy;Architecture;Attention;Axon;axon growth;axon regeneration;behavior measurement;biofabrication;Biology;Biomass;Biomedical Engineering;Biomimetics;Blood Vessels;Cell Density;Cell Survival;Cells;Chronic;Clinical;clinical translation;clinically relevant;Collagen;Control Groups;Defect;Degenerative Disorder;design;Development;developmental disease;Dimensions;Disease;Dose;Electrophysiology (science);Engineering;Environment;expectation;experimental group;Extracellular Matrix;Fascicle;Formulation;Frequencies;Functional disorder;Functional Regeneration;functional restoration;Gene Expression;Goals;Graft Survival;Growth;histological stains;histological studies;Human;human induced pluripotent stem cells;human tissue;Implant;implantation;In Vitro;in vivo;Individual;Injury;Intervention;Light;Measurement;Measures;Medical center;Modeling;Morphology;Motor;motor deficit;Motor Neurons;multidisciplinary;Muscle;Muscle Cells;Muscle Contraction;Muscle Development;muscle engineering;Muscle Fibers;muscle form;muscle regeneration;muscle repair;Muscle satellite cell;muscular system;musculoskeletal injury;myogenesis;Natural regeneration;Nerve;nerve supply;neural;neuromuscular;Neurons;neurophysiology;neurovascular;non-invasive imaging;Operative Surgical Procedures;Optics;optogenetics;Pattern;PECAM1 gene;Pennsylvania;Periodicity;Philadelphia;Physiological;Physiology;Play;Population;Pre-Clinical Model;Process;programs;protein expression;Rattus;reconstruction;Recovery of Function;regenerative;Regenerative capacity;Regenerative Medicine;regenerative therapy;reinnervation;repaired;replacement tissue;response;revascularization;Rodent Model;Role;scaffold;self assembly;Sensorimotor functions;Skeletal Muscle;skeletal muscle wasting;soft tissue;spatiotemporal;Structure;Techniques;Testing;Time;Tissue Engineering;tissue regeneration;Tissues;Transducers;Universities;Vascular blood supply;Vascular System;Vascularization;volumetric muscle loss;Weight

PROJECT_TITLE: Tissue Engineered Motor Units for Neuromuscular Modeling and Repair

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Brain Disorders;Depression;Mental Health;Neurosciences;Sleep Research

ORG_DEPT: NEUROSCIENCES

PHR: NARRATIVE Sleep in depression is characterized by disinhibited rapid eye movement (REM) sleep with an increased density of rapid eye movements. The proposed studies aim to dissect the circuit mechanisms by which the prefrontal cortex, a brain area hyperactivated in depressed patients, regulates REM sleep and the eye movement density through interaction with subcortical areas in hypothalamus and brainstem. The results are a critical precursor to understanding the causal relationship between cortical dysfunction in psychiatric disorders and sleep disturbances.

PI_NAMEs: WEBER, FRANZ L (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Area;Axon;Biological Markers;Brain;Brain Stem;Calcium;Cell Nucleus;cell type;Characteristics;Clinical;clinically relevant;Data;density;depressed patient;Disease;Disinhibition;Electroencephalography;Emotional;experimental study;Eye Movements;Facial Expression;Fiber;Frequencies;Functional disorder;Goals;Health;hippocampal pyramidal neuron;Human;Hypothalamic structure;Image;In Situ Hybridization;in vivo;in vivo calcium imaging;Lateral;Maintenance;Major Depressive Disorder;Medial;Memory;Mental Depression;Mental disorders;microendoscopy;Mood Disorders;Mus;neuromechanism;Neurons;novel;optogenetics;Output;Pathway interactions;Pedunculopontine Tegmental Nucleus;Performance;Phase;Photometry;Pontine structure;Population;postsynaptic;postsynaptic neurons;Prefrontal Cortex;rapid eye movement;recruit;Regulation;REM Sleep;Role;sensor;Sleep;Sleep disturbances;Structure;Synapses;Testing;Viral;Virus

PROJECT_TITLE: Cortical Regulation of REM Sleep

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), and cholestatic liver diseases, are major health problems both for Veterans and the general population. Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related mental disorder which poses a significant impact on veterans’ health. The prevalence of PTSD is much higher in Veterans than in general populations, especially in combat Veterans. PTSD can result in end-organ damage, such as liver cirrhosis. Both cirrhosis and PTSD independently lead to dysregulation of the gut microbiome and brain dysfunction. Understanding bile acids and sphingolipids in regulating hepatic lipid metabolism, immunity, and biliary function under different pathological conditions will provide a foundation for discovering new diagnostic markers and novel pharmaceutical interventions for the prevention and treatment of various liver diseases and PTSD-associated liver injury, which are important problems for our Veteran patients.

PI_NAMEs: ZHOU, HUIPING ROSE (contact)

PROJECT_TERMS: Address;Alcoholic Liver Diseases;American;Animal Model;Appointment;Award;Bile Acids;Biliary;Brain;brain dysfunction;career;career development;Cellular Metabolic Process;Cholestasis;Chronic Disease;chronic liver disease;Cirrhosis;Clinical;clinically relevant;cognitive function;Collaborations;combat veteran;Communication;Complex;diagnostic biomarker;Disease Progression;drug induced liver injury;dysbiosis;Fatty Acids;Foundations;Funding;Gastrointestinal Diseases;General Population;Goals;graduate student;Grant;gut dysbiosis;gut microbiome;Health;Health system;Healthcare;Hepatic;Hepatology;Homeostasis;Immunity;Immunology;Impaired cognition;Impairment;indexing;Inflammatory;inflammatory milieu;International;Intervention;intestinal barrier;Investigation;Journals;Lead;Leadership;Link;lipid metabolism;Liver;Liver Cirrhosis;Liver diseases;liver injury;Mediating;Medical center;member;Mental disorders;Mentors;Mentorship;microbial;Microbiology;Mission;multidisciplinary;nano-string;Nature;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel diagnostics;Organ;Pathologic;Patient Care;Patients;Peer Review;Pharmacologic Substance;Physicians;Physiology;Play;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Prevalence;Prevention;primary sclerosing cholangitis;Process;Productivity;Professional Organizations;programs;Publications;Research;Research Personnel;Resources;Role;Scientist;senior faculty;Services;Sheep;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Societies;Sphingolipids;stressor;Techniques;Testing;Training;Trauma;undergraduate student;Universities;Veterans;Virginia;Volatile Fatty Acids

PROJECT_TITLE: BLR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Taste is important for making decisions about what to eat, and altered taste perception is associated with obesity and eating disorders. This proposal uses a tractable model system, the fruit fly, to investigate basic mechanisms of how taste signals are processed in the brain. Given the similarities in how flies and mammals respond to taste, we expect to uncover fundamental principles of taste processing that generalize across species, laying the groundwork to study how these mechanisms are dysregulated in disease.

PI_NAMEs: DEVINENI, ANITA VANI (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Affect;Altered Taste;Area;Behavior;Behavioral;Behavioral Assay;Behavioral Paradigm;behavioral response;Biological Models;Brain;Brain region;cell type;Cells;Classification;Code;Computer Analysis;Computer Models;Cues;Decision Making;Dependence;Disease;Dose;Drosophila genus;Drosophila melanogaster;Eating;Eating Disorders;experimental study;feeding;flexibility;fly;Foundations;Genetic;Goals;Hunger;Hyperphagia;Image;in vivo calcium imaging;Individual;Learning;Locomotion;Mammals;Methods;Modeling;Monitor;Motor;Neurons;Neurosciences;Obesity;optogenetics;Organ;Output;Pathway interactions;Population;predicting response;preference;Process;Property;response;Role;Sensory;sensory input;sensory system;Signal Transduction;Synapses;System;Taste Perception;taste stimuli;taste system;Testing;tool;transmission process;Work

PROJECT_TITLE: Dissecting the first layer of central taste processing in Drosophila

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Powassan virus (POWV) is a tick-borne virus that causes a 10% fatal brain disease, and a new tick POWV isolate, LI9, was found to cause highly lethal brain damage in aged mice, a finding that mimics POWV disease in elderly patients. In contrast, an attenuated POWV, LI9-P, fails to cause brain damage in mice and is a potential vaccine that differs in its ability to regulate antiviral responses of cells that form brain barriers. Paired lethal and attenuated POWVs, and our unique ability to modify POWVs, permit us to propose defining determinants of POWV disease, mechanisms of POWV entry into the brain, age-dependent POWV virulence mechanisms and potential inhibitors of brain damage applicable to elderly POWV patients.

PI_NAMEs: MACKOW, ERICH R (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Age;age related;aged;Anti-viral Response;Astrocytes;Attenuated;attenuation;Black-legged Tick;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Brain;brain control;Brain Diseases;brain endothelial cell;Brain Injuries;C57BL/6 Mouse;Cell-Matrix Junction;Cells;chemokine;Chimera organism;Choroid Plexus Epithelium;Disease;Elderly;Encephalitis;Epithelial Cells;Failure;Genetic Determinism;genetic element;Hematogenous;Histopathology;Human;IL1R1 gene;Immune;immune cell infiltrate;Immunohistochemistry;In Vitro;in vivo;Incidence;Infection;Inflammatory;Inflammatory Response;inhibitor;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-1 Receptors;Kinetics;Modeling;Mus;mutant;Nervous System Trauma;neuroinflammation;neurovascular;neurovirulence;novel;old mice;older patient;Pathogenesis;Pathology;Patients;Pericytes;Powassan virus;prevent;Proteins;Rationalization;Recombinants;recruit;Regulation;Reporting;response;single-cell RNA sequencing;Skin;Slice;Stains;Structure of choroid plexus;tick bite;tick saliva;tick-borne flavivirus;tick-borne virus;Ticks;Tight Junctions;Vaccines;Vascular Endothelial Cell;Viral;Viremia;virtual;Virulence;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of Age Dependent Powassan Virus Neurovirulence

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Nearly all pregnant individuals with type 2 diabetes mellitus experience either maternal or newborn morbidity, with disparities seen in socially disadvantaged groups. The proposed study seeks to improve outcomes in pregnant individuals with type 2 diabetes by testing the effectiveness of continuous glucose monitoring, which was shown to be beneficial in type 1 diabetes pregnancies. Successful completion of the study will not only determine if continuous glucose monitoring is superior to self-monitoring of blood glucose, but also identify optimal glucose targets for management of type 2 diabetes in pregnancy and the key social determinants of health affecting outcomes in this high-risk population.

PI_NAMEs: BATTARBEE, ASHLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Address;Admission activity;adverse outcome;Affect;Biological;Birth trauma;Blood Glucose Self-Monitoring;CEACAM7 gene;Cesarean section;Cessation of life;Child;Complex;Consensus;Continuous Glucose Monitor;Data;diabetes management;Diabetes Mellitus;Disease;Disparity;Disparity population;disparity reduction;Dystocia;effectiveness evaluation;effectiveness testing;Ensure;Ethnic Origin;experience;Fasting;Foundations;Future;Gestational Age;Gestational Diabetes;Glucose;glucose monitor;glycemic control;Goals;Guidelines;health equity;high risk population;Hyperbilirubinemia;Hypoglycemia;improved;improved outcome;Individual;Infection;Insulin-Dependent Diabetes Mellitus;Intervention Studies;Knowledge;low socioeconomic status;maternal hyperglycemia;maternal morbidity;maternal outcome;Measures;meetings;Methods;Morbidity - disease rate;mortality;multidisciplinary;Neonatal Hypoglycemia;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;neonatal outcome;neonate;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;open label;Outcome;outcome disparities;Patients;Perinatal mortality demographics;Population;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy in Diabetics;pregnant;Premature Birth;prevent;Provider;racial minority;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Risk;Risk Reduction;Shoulder;Site;social;social determinants;social disparities;social factors;social health determinants;Spontaneous abortion;stillbirth;structural determinants;success;Testing;Time;tool

PROJECT_TITLE: Continuous glucose monitoring for management of type 2 diabetes in pregnancy (CGM2 trial)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: CINCINNATI

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Traumatic peripheral nervous system injuries have a devastating impact on patient quality of life and currently lack therapies for consistent functional recovery. The proposed project will develop and demonstrate the feasibility of an ultrashock-mediated, biocompatible, piezoelectric scaffold integrated with integrated bioactivity. The scaffold will transmit the necessary electrical, physical, and chemical signals to initiate and improve cell-biomaterial interactions, minimize the immune response, and facilitate peripheral nerve regeneration in critical injury gaps.

PI_NAMEs: HARRIS, GREG M (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;American;animal tissue;axon guidance;axon injury;axon regeneration;bioactive scaffold;Biochemical;Biocompatible Materials;biomaterial compatibility;bioscaffold;cell type;Cells;Cellular Morphology;Chemicals;Clinical;clinical translation;Communication;Cues;Devices;Distal;Electric Stimulation;electrical potential;Electrodes;Extracellular Matrix;Fibroblasts;Fluorides;Functional disorder;Genetic Transcription;Goals;Growth;Immune response;Implant;implantation;Implanted Electrodes;improved;In Vitro;in vivo;in vivo regeneration;injured;Injury;insight;Mechanical Stimulation;Mechanics;Mediating;Movement;Muscle;Nerve;nerve gap;Nerve Regeneration;nerve repair;nerve supply;Nervous System Trauma;Neurons;neurotrophic factor;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;peripheral nerve regeneration;peripheral nerve repair;Peripheral Nerves;Peripheral Nervous System;Persons;Phenotype;polyvinylidene fluoride;Production;Proliferating;Quality of life;Recovery of Function;regeneration potential;regenerative;repaired;response;Rodent Model;scaffold;Schwann Cells;severe injury;Signal Transduction;Stimulus;subcutaneous;Swelling;Tissues;Toxic effect;Traction;transdifferentiation;transmission process;vinyl fluoride;wireless

PROJECT_TITLE: Developing multi-cue piezoelectric PVDF-TrFE biomaterials for peripheral nerve repair


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Physical Activity;Precision Medicine

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Although cardiovascular congestion is the hallmark of heart failure our understanding of mechanisms that lead to cardiovascular congestion and potential treatment options remain limited. Supported by our recent work, cardiac congestion and decompensation could be the result of internal volume redistribution from the splanchnic vascular compartment but validation of this innovative concept and novel therapeutic intervention requires detailed physiological testing. During this project, we will test the safety and mechanisms of action of prolonged splanchnic nerve blockade on exercise performance in patients with chronic heart failure and we will learn relevant methodology in phenotyping patients with chronic heart failure.

PI_NAMEs: FUDIM, MARAT  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Abdomen;Ablation;Activities of Daily Living;Acute;Address;Adult;Affect;Anatomy;Animals;Autonomic nervous system;Blood;Blood Vessels;Blood Volume;body volume;Cardiac;Cardiopulmonary;Cardiovascular system;Catheters;Chest;Chronic;Classification;Clinical;cohort;Congestive Heart Failure;Diagnostic;Disease;Disease Progression;Diuretics;Dyspnea;Edema;Excision;Exercise;Exercise Test;follow-up;Foundations;Functional disorder;functional status;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;hemodynamics;Hospitalization;Hour;Human;Hypovolemia;Hypovolemics;Image;Imaging Device;improved;improved outcome;in vivo;innovation;Interruption;Knowledge;Learning;Liquid substance;Lung;Measures;Mediating;Medical;Methodology;Nerve;neurotransmission;novel;novel therapeutic intervention;Outcome;Oxygen Consumption;participant enrollment;patient subsets;Patients;Pattern;Performance;personalized approach;personalized medicine;Phenotype;Physical activity;physiologic model;Physiological;Plethysmography;Population;Predictive Factor;pressure;Prevalence;Randomized;response;Rest;safety testing;sham-controlled study;Splanchnic Nerves;success;Symptoms;Testing;Therapeutic;therapeutic target;treatment arm;ultrasound;Validation;Visualization;Work

PROJECT_TITLE: Splanchnic Nerve Modulation In Heart Failure (Splanchnic X)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE BRAF activating mutations occur in approximately 10% of metastatic colorectal cancer (CRCs) and are associated with worse prognosis due to an inferior response to standard chemotherapy. With the use of more potent targeted therapy, shifts in cell identity due to epithelial cell plasticity is an emerging cause of therapy resistance. The overall goal of this study is to develop an epigenetic inhibitor-based therapeutic strategy to block therapy-induced shifts in cell identity in BRAF mutant CRC and prolong responses to targeted therapy and improve clinical outcomes for patients with this disease.

PI_NAMEs: O'HAGAN, HEATHER M (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adenocarcinoma;Androgen Antagonists;BRAF gene;cancer cell;Cancer Model;Cell Differentiation process;Cell Lineage;Cell secretion;Cell Survival;Cells;chemotherapy;Clinical;Clinical Trials;clinically relevant;colon cancer cell line;Colorectal Cancer;Combined Modality Therapy;Complex;cytokine;Data;Disease;Effectiveness;Enteroendocrine Cell;Epidermal Growth Factor Receptor;Epigenetic Process;Epithelial Cells;Experimental Designs;Gene Expression;Genetic;Genomics;Goals;Growth;Hormones;Human;Immune;immune activation;Immune checkpoint inhibitor;improved;In Vitro;in vivo;in vivo Model;Inferior;inhibitor;Intestines;KDM1A gene;knock-down;loss of function;Lysine;Malignant neoplasm of lung;Malignant neoplasm of prostate;Mediating;metastatic colorectal;Microsatellite Instability;Microsatellite Repeats;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;Neuroendocrine Cell;neuroendocrine phenotype;novel;novel therapeutic intervention;Organoids;Outcome;Pathology;Pathway interactions;Patient Care;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Population;prevent;Prior Therapy;Prognosis;Proteins;Publishing;Receptor Inhibition;recruit;Resistance;resistance mechanism;response;Signal Induction;standard of care;Stat3 protein;stem cells;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;tool;transcription factor;transdifferentiation;treatment response;tumor;tumor heterogeneity;tumor-immune system interactions;Work

PROJECT_TITLE: Targeting LSD1 to prevent therapy-induced transdifferentiation in BRAF mutant colorectal cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The proposed study will integrate and analyze longitudinal multi-omics data, which spans epigenome, metabolome, and microbiome, to comprehensively characterize the molecular connections between maternal exposures to traffic-related air pollution and preterm birth among 700 participants in a socio-economically diverse, exceptionally phenotyped African American Maternal-Child cohort. The study approaches will include novel exposure assessment through existing external, traffic emission exposure modeling paired with internal, high-resolution multi-omics data integration. We expect this work to contribute to elucidating potentially sensitive TRAP biomarkers and preclinical indicators for PTB - a meaningful step for defining novel intervention strategies to mitigate traffic-related air pollution exposure risk and improve birth and health outcomes in exposed mothers and children.

PI_NAMEs: LIANG, DONGHAI  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;adverse birth outcomes;Affect;African American;African American population;Air Pollution;Attention;Bioinformatics;bioinformatics tool;Biological;Biological Markers;Biological Monitoring;Birth;C-reactive protein;Child;Child Health;Clinical;cohort;Color;Communities;Complex;cytokine;Data;data integration;Detection;Disease;DNA Methylation;Dose;early pregnancy;Environmental Health;epigenome;Exhalation;experience;Experimental Models;Exposure to;feature selection;Future;Gases;gut microbiome;Health;Health Benefit;health disparity;improved;Inflammation;Inflammatory;innovation;insight;Intervention;Knowledge;Late pregnancy;Link;longitudinal analysis;Maps;Maternal Exposure;Measurement;Mediating;Metabolic Pathway;metabolome;metabolomics;Methods;methylation pattern;microbial;microbiome;Modality;Modeling;Molecular;Mothers;multidisciplinary;Multiomic Data;multiple omics;Nitric Oxide;novel;Outcome;Oxidative Stress;Participant;particle;Pathway interactions;Persons;Phenotype;pollutant;potential biomarker;pre-clinical;Pregnancy;pregnant;Premature Birth;prenatal;prenatal exposure;Process;prospective;Public Health;Research Personnel;Resolution;response;Risk;Risk Assessment;Risk Reduction;Role;Sample Size;Shapes;Signal Transduction;Site;socioeconomics;specific biomarkers;Techniques;Time;Toxic effect;toxicant;traffic-related air pollution;vaginal microbiome;Work

PROJECT_TITLE: The Omics and Mixtures Integration on Traffic exposure and Preterm Birth (OMIT-PTB) Study

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Obesity;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Diabetes;Machine Learning and Artificial Intelligence;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Identifying neural markers of increased vulnerability for obesity in very young children exposed to maternal diabetes may enhance our understanding of etiologic pathways of obesity development and serve as a springboard for the development of early interventions before the risks manifest as long-term consequences. Given the vast health costs associated with obesity, knowledge gained from this study could offset the burden associated with obesity.

PI_NAMEs: LUO, SHAN  (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: 3 year old;Accounting;Adolescent obesity;Affect;Age;Area;Behavioral Mechanisms;Big Data;Biochemical Pathway;Birth;Body Weight;Brain;brain abnormalities;brain based;Brain Mapping;Brain region;Cardiovascular Diseases;Child;Classification;cognitive control;cohort;Cohort Studies;Country;critical period;Data;Data Analyses;data analysis pipeline;data harmonization;Data Set;deep learning model;design;Development;Diabetes Mellitus;Diffusion;Diffusion Magnetic Resonance Imaging;early childhood;Early Intervention;Economic Burden;Etiology;Exposure to;Functional Magnetic Resonance Imaging;Funding;Future;Genetic;Genomics;Goals;Growth;Health Care Costs;health economics;high risk;Hippocampus;Hypothalamic structure;Image;imaging modality;Individual;infancy;Infant;innovation;insight;Intervention;Knowledge;Length;Life;Link;machine learning algorithm;Maps;maternal diabetes;maternal obesity;Measures;Meta-Analysis;Metabolic;Modeling;Multimodal Imaging;multimodal neuroimaging;multimodality;neonate;neural;neuroimaging;Neurosciences;Obesity;obesity development;obesity in children;obesity risk;offspring;offspring obesity;Overweight;Pathway interactions;Perinatal Exposure;Population;predictive marker;predictive modeling;predictive signature;Pregnancy;Pregnancy in Diabetics;prenatal exposure;prepregnancy obesity;Prevention strategy;Public Health;Reproducibility;Resources;Rest;Rewards;Risk;Risk Factors;Site;socioeconomics;Structure;Surface;Techniques;Testing;Thick;Treatment Efficacy;Uncertainty;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Effects of Maternal Diabetes on early brain development


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Heart Disease;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Congenital Heart Defects (CHDs) are the major cause of mortality in children with 22q11.2 deletion syndrome (DS), the most common deletion syndrome in humans. While it is known that the CHDs in 22q11.2DS patients are caused by reductions in the transcription factor TBX1, the precise mechanism remains unclear. Here, we will use zebrafish tbx1 mutants as a model of 22q11.2 DS to uncover how Tbx1 regulates cardiovascular development.

PI_NAMEs: BURNS, CAROLINE E (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 22q11;Address;Animal Model;Animals;Anterior;aortic arch;Arteries;ATAC-seq;Biological Models;biomarker identification;Branchial arch structure;Cardiac;Cardiac Myocytes;Cardiovascular system;Cell Lineage;Cell Nucleus;Cells;Cephalic;Child;Childhood;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Congenital Heart Defects;craniofacial;Data Set;Defect;Development;differential expression;DiGeorge Syndrome;Dissection;Embryo;experimental study;follow-up;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Epistasis;genetic strain;Geography;Guide RNA;Head;Heterogeneity;Human;imaging capabilities;In Situ Hybridization;insight;Knock-in;Laboratories;Lateral;Learning;Link;Maps;Mesoderm;microdeletion;model organism;Modeling;Molecular;mortality;multiple omics;Muscle;mutant;Patients;Pattern;Pharyngeal Apparatus;Pharyngeal structure;Phenotype;Population;preservation;progenitor;Reporter;Reporting;Resolution;Series;single-cell RNA sequencing;small molecule;Somites;Specific qualifier value;stem cell fate;stem cell fate specification;stem cell population;stem cells;Structure;Surface;Syndrome;System;Testing;Time;tool;transcription factor;transcriptomics;Tretinoin;Undifferentiated;Zebrafish

PROJECT_TITLE: Mechanistic dissection of 22q11.2DS in zebrafish

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Congenital heart disease (CHD) affects about 40,000 births per year (1%) in the United States and these children require life-long monitoring of their heart health. This project aims to develop, validate, and clinically evaluate a magnetic resonance imaging (MRI) method to measure blood ﬂow in pediatric CHD patients. We will disseminate a “push-button” MRI package to increase diagnostic accuracy and improve clinical conﬁdence in decision making for pediatric CHD patients.

PI_NAMEs: ENNIS, DANIEL B (contact);VASANAWALA, SHREYAS S

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;4D MRI;Adult;Affect;Algorithms;Anatomy;Birth;Blood;Blood flow;Cardiac health;Cardiovascular system;Characteristics;Child;Childhood;Clinical;clinical care;Compensation;Complex;Cone;congenital heart abnormality;Data;data acquisition;Data Set;Decision Making;deep learning;diagnostic accuracy;Diagnostic Imaging;diagnostic value;Dimensions;Echocardiography;Evaluation;heart function;hemodynamics;Hour;Image;image reconstruction;imaging modality;improved;Individual;innovation;Intervention;Ionizing radiation;Magnetic Resonance Imaging;Measurement;Measures;Memory;Methods;Monitor;Morphologic artifacts;Motion;Operative Surgical Procedures;Patients;pediatric patients;Performance;Phase;Physiologic pulse;prospective;Randomized;reconstruction;repaired;Resolution;respiratory;Sampling;Scanning;soft tissue;spatiotemporal;temporal measurement;Time;time use;tool;Training;training data;United States;Validation;Vendor

PROJECT_TITLE: Fast and Accurate Cardiovascular MRI with Hyper 4D-Flow

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: SOCIAL SCIENCES

PHR: Public Health Relevance Information on how the risk of death varies with age during the late fetal and neonatal periods in a resource- poor setting like India represents critical evidence for health policy. This information, together with risk factors such as preterm, low birthweight and small for gestational age, will help understand which newborns are most at risk of death, guide policy action and improve progress for children. The present study will make important substantive and methodological contributions to understanding the dynamics of late fetal and neonatal mortality in the Indian context, with implications for other low- and middle-income countries where stillbirth and neonatal mortality rates remain high.

PI_NAMEs: GUILLOT, MICHEL  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse birth outcomes;Africa South of the Sahara;Age;Area;Biological;Birth;Birth Weight;Cessation of life;Child;Country;Data;Data Collection;Death Rate;Demographic and Health Surveys;Environment;Excess Mortality;fetal;Gender;Gestational Age;girls;global health;Goals;Health;Health Policy;improved;India;Infrastructure;innovation;Joints;Late Fetal Mortality;Live Birth;low and middle-income countries;Low Birth Weight Infant;low income country;Measurement;Methodology;Monitor;mortality;mortality risk;Neonatal;Neonatal Mortality;neonatal period;Newborn Infant;novel;Outcome;Pattern;Play;Policies;Population;postneonatal mortality;Pregnancy;Premature Birth;prospective;Protocols documentation;public health relevance;Resource-limited setting;Risk;Risk Factors;Role;sex;Site;Small for Gestational Age Infant;social;Source;South Asian;stillbirth;Sustainable Development;Time;ultrasound;Women's mortality

PROJECT_TITLE: The dynamics of late fetal and neonatal mortality in the Indian context

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We plan to investigate the effect of implant design and surface architecture on the foreign body and fibrotic responses to glaucoma drainage implants. We will then incorporate optimal materials and surface features into a novel glaucoma drainage implant design and compare its effectiveness to commercially available implants. This research may influence the design of a next generation of implants with improved biological integration and long-term efficacy, and help prevent disease progression and vision loss in glaucoma patients.

PI_NAMEs: PARIKH, KUNAL SAILESH;PITHA, IAN FRANZ (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Affect;anterior chamber;Aqueous Humor;Architecture;Atomic Force Microscopy;beneficiary;Biocompatible Materials;Biological;biomaterial compatibility;Blindness;Bulla;Cicatrix;Clinic;Clinical;clinical efficacy;clinical practice;Color;cost;Cues;Data;design;Devices;Diameter;Dimensions;Disease Progression;Drops;Effectiveness;Electrons;Electrospinning;Encapsulated;Engineering;Evaluation;Eye;Eyedrops;Failure;Fibroblasts;Fibrosis;Filtering Surgery;Flow Cytometry;Foreign Bodies;Formulation;Gel;Genes;Genetic Transcription;Glaucoma;Glaucoma Drainage Implants;glaucoma surgery;healthcare burden;Healthcare Systems;Histologic;Histology;Immunofluorescence Immunologic;Implant;implant design;implantation;Implantation procedure;improved;improved outcome;In Vitro;in vivo;Individual;Inflammation;insight;Intervention;Lead;Legal patent;Libraries;Liquid substance;manufacture;Measurement;Medical Device;Medicare;migration;minimally invasive;Modeling;modifiable risk;Morphology;Mus;nanoarchitecture;Nanostructures;next generation;normotensive;novel;novel strategies;Ocular Hypertension;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phase;Physiologic Intraocular Pressure;Polymers;Porosity;Postoperative Complications;Postoperative Period;pressure;prevent;Procedures;Process;Profibrotic signal;Property;Proteins;rational design;Repeat Surgery;Reporting;Research;response;Risk Factors;Safety;Scanning;Scanning Electron Microscopy;screening;Shunt Device;Signal Pathway;Silicones;skills;Standardization;Stents;Stress Fibers;Subcutaneous Tissue;Surface;Surgeon;Thick;Time;Tissues;Trabeculectomy;Transforming Growth Factor beta;Tube;Vent;Visit;Visual

PROJECT_TITLE: Understanding and optimizing the influence of glaucoma drainage implant surface architecture and design to prevent post-operative fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Diabetic cardiomyopathy is a major complication and the leading cause of death and disability in patients with diabetes. Exercise is an effective strategy for the prevention and treatment of diabetic cardiomyopathy, however, the underlying molecular mechanisms remain poorly understood. The proposed research will explore the role of METTL3, a N6-methyladenosine methyltransferase, in diabetic cardiomyopathy and the cardiac benefits of exercise, with the vision of establishing clinically relevant approaches targeting METTL3 to treat diabetic cardiomyopathy. 1

PI_NAMEs: LI, HAOBO  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adenosine;Animal Model;Animals;Binding;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;cardioprotection;Cause of Death;Cell Death;Cessation of life;Clinical;clinically relevant;combat;Complication;Data;db/db mouse;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;dietary;disability;DNA binding protein B;Dose;effective therapy;EFRAC;Eukaryota;Exercise;fat mass and obesity-associated protein;functional decline;Functional disorder;gain of function;Gene Delivery;Genes;Genetic;Glucose;Goals;Growth;Heart;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;High Fat Diet;improved;improved outcome;In Vitro;knock-down;Knock-out;Knockout Mice;Learning;loss of function;LoxP-flanked allele;Mediating;Methylation;Methyltransferase;Modeling;Modification;Molecular;Monitor;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;overexpression;Oxidative Stress Induction;Palmitates;Pathway interactions;Patients;Physiological;preservation;Prevention strategy;Prognosis;protective effect;Reader;Regulation;Research;response;RNA;RNA immunoprecipitation sequencing;RNA methylation;Role;Streptozocin;targeted treatment;Testing;Time;treadmill training;Vision

PROJECT_TITLE: METTL3 in Cardiac Benefits of Exercise in Diabetes

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Gut bacterial pathogens need to obtain nutrients to colonize and infect intestinal environments. The consumption of preferred substrates and micronutrients by commensals offers opportunities to target critical events in pathogen colonization and infection. The pathogen Clostridioides difficile has a diverse metabolism that supports gut colonization. Using target fermentable substrates metabolized by protective commensals and/or by C. difficile, we will evaluate molecular mechanisms by which target fermentable substrates interact with the host, pathogen and commensals to modulate critical events in pathogen colonization, infection, and resolution. Findings will be evaluated in conventional mouse models to inform targeted approaches using small molecule, bacteriotherapeutic, or combined approaches to mitigate risks for these infections.

PI_NAMEs: BRY, LYNN  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Ablation;absorption;Acute;Affect;amino acid metabolism;Amino Acids;Anaerobic Bacteria;Antibiotics;Automobile Driving;bacterial metabolism;Biomass;Carbohydrates;Carbon;Chronic;Clindamycin;Clostridium;Clostridium difficile;Complex;Consumption;Diet;dietary;Disease;disorder prevention;Environment;Equilibrium;Event;Exposure to;Fermentation;Gene Expression;Generations;Genome;Germ-Free;Glucose;Glycine;Gnotobiotic;Growth;gut colonization;In Vitro;in vivo;Infection;Infection prevention;infection risk;innovation;Intervention;Intestines;Label;Leucine;Magic;Mannitol;Metabolic;Metabolism;microbiota;Micronutrients;Molecular;mouse model;Mus;Nutrient;Nutrient availability;Nutrient Depletion;Oral;Oral Administration;Outcome;Oxidation-Reduction;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phenotype;Process;Production;programs;Proline;recruit;Resolution;risk mitigation;Role;small molecule;Source;Substrate Interaction;Sugar Alcohols;Sweetening Agents;System;Tissues;Toxin;toxin metabolism;Virulence;Work;Xylitol

PROJECT_TITLE: Harnessing commensal redox metabolism in infection prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cannabis and alcohol are the two most widely used substances among emerging adults (~ ages 18-25), with elevated rates of use among sexual minoritized emerging adults in college settings. This K23 involves developing a technology-driven, app-based intervention with input from community partners (e.g., campus resource centers) and students with lived experience that will lead to the development of a novel adaptive intervention for sexual minoritized emerging adult college students who report cannabis and alcohol co-use (i.e., using both substances within the same period [e.g., past month], which could be different occasions or simultaneously so drug effects overlap). Given the high rates of smartphone use among this population, if the efficacy is established, this intervention will have great promise for increasing delivery of efficacious co-use interventions for sexual minoritized emerging adult college students, thereby benefiting public health.

PI_NAMEs: FLORIMBIO, AUTUMN RAE H (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;access disparities;adaptive intervention;Address;Age;Alcohols;Behavior;Behavior Therapy;Cannabis;career;Cellular Phone;Characteristics;Collection;college;Communities;community partners;Consumption;coping;Data;Data Collection;Development;Discrimination;Distress;Dose;Early Intervention;efficacious intervention;emerging adult;emerging adulthood;Environment;Evaluation;experience;feasibility testing;Feedback;Gender;Goals;Grain;harassment;Health;Health Services Accessibility;Heterosexuals;high risk;high risk population;Image;improved;Individual;innovation;Intervention;intervention delivery;intervention refinement;Knowledge;Learning;Lesbian Gay Bisexual;Literature;Lived experience;Love;marijuana use;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;minority stress;minority student;Modeling;Monitor;Motivation;non-heterosexual;novel;pansexual;Participant;Pattern;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase Transition;Population;Prevalence;Procedures;protective factors;psychoeducation;Public Health;Recommendation;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Risk Behaviors;Risk Factors;Same-sex;satisfaction;Scientist;screening;Self Care;Sequential Multiple Assignment Randomized Trial;Severities;Sex Orientation;sexual minority;sexual minority group;skill acquisition;skills;smartphone application;social stigma;Stress;stressor;Students;substance use;Substance Use Disorder;substance use prevention;Target Populations;Targeted Research;Technology;Testing;theories;therapy development;Time;Training;Training Activity;Treatment Efficacy;trial design;Universities;university student;usability;Variant;Visualization

PROJECT_TITLE: Optimizing an App-based Intervention for Sexual Minoritized Emerging Adults to Reduce Cannabis and Alcohol Co-use

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Nanotechnology;Urologic Diseases

PHR: NARRATIVE The goal of this R01 proposal is to assess the efficacy of a new precision cancer targeting approach using CRISPR technology that brings together a “split” endonuclease precisely at structural variant junctions in bladder cancer cells. This approach is targeting only the cancer cells and is not dependent on the specific tumor biology of the cancer. This personalized and tumor-specific targeting approach is a paradigm-shifting platform technology that could transform bladder cancer treatments.

PI_NAMEs: LJUNGMAN, MATS  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Animal Model;Apoptosis;Binding;Bioinformatics;Biology;Bladder;Bladder Neoplasm;Cancer Biology;cancer cell;Cancer cell line;Cancer Model;cancer therapy;carcinogenicity;Cell Culture Techniques;Cell Death;Cell Line;Cells;Chromosomes;Circulation;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;CRISPR/Cas technology;design;Development;Dimerization;Disease;Disseminated Malignant Neoplasm;DNA Double Strand Break;DNA Sequence Alteration;efficacy evaluation;efficacy testing;Elements;Encapsulated;endonuclease;Enzymes;Essential Genes;Funding;Gamma-H2AX;Gene Dosage;Genome;genome-wide;Genomic Instability;Genomics;Goals;Growth;Guide RNA;Human;Image;in vivo;innovation;Libraries;lipid nanoparticle;Malignant neoplasm of urinary bladder;Malignant Neoplasms;manufacture;Maps;Medicine;Messenger RNA;Modeling;Monitor;mouse model;Mus;nanoparticle delivery;neoplastic cell;Normal Cell;Oncogene Activation;Oncogenes;Oncogenic;particle;Patients;pre-clinical;preclinical efficacy;Process;Reagent;Research Personnel;resistance mechanism;System;Technology;technology platform;Testing;Therapeutic;Time;Toxic effect;tumor;Tumor Biology;Tumor Suppressor Genes;Variant;Vesicle;Work

PROJECT_TITLE: Precision targeting of bladder cancer using CRISPR

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Diabetes;Kidney Disease;Nutrition;Obesity;Organ Transplantation;Physical Activity;Prevention;Transplantation

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative For patients with end-stage renal disease, kidney transplantation is the best clinical treatment. Weight and adipose gain following kidney transplantation has been implicated for deleterious cardiometabolic effects. This pilot and feasibility clinical trial is being implemented to evaluate the feasibility and plausible effectiveness of a lifestyle intervention on change in weight, effects on cardiometabolic biomarkers, and kidney function in kidney transplant recipients. If feasible and plausible this will provide the foundation for a full-scale clinical trial.

PI_NAMEs: CIBRIK, DIANE M;JAKICIC, JOHN M (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Adipose tissue;adverse outcome;Area;Biological Markers;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolism;Caring;Clinical;Clinical Treatment;Clinical Trials;Combination Medication;Conduct Clinical Trials;Cost Effectiveness Analysis;Data;Development;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;Effectiveness;End stage renal failure;energy balance;Energy Intake;Energy Metabolism;experience;Feasibility Studies;Feedback;Focus Groups;Foundations;Funding Mechanisms;Funding Opportunities;Glucose Intolerance;glucose metabolism;graft failure;Health;high risk;Human;Impairment;improved;Insulin Resistance;Intervention;intervention effect;Kansas;Kidney;Kidney Transplantation;lifestyle intervention;Literature;Manuals;Medical center;Methods;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;organ procurement transplantation network;Organ Procurements;Outcome;Outcome Measure;Participant;participant retention;Pathway interactions;patient population;Patients;Physical activity;Physician Executives;Pilot Projects;prevent;Prevention;Procedures;Process;programs;Protocols documentation;Provider;Randomized;Recommendation;recruit;Renal function;Reporting;Safety;Sample Size;standard care;systematic review;Testing;Transplant Recipients;Transplantation;United States;Universities;Weight;Weight Gain;weight gain prevention;Work

PROJECT_TITLE: Prevention of Weight Gain and Impaired Glucose Metabolism Post Kidney Transplantation: A Pilot and Feasibility Study

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative A molecular pathway that links N-glycosylation to birth defects Damage to cell-cell communications systems can cause a variety of human birth defects. We have uncovered a system that tunes the volume of a key developmental signal between cells. By understanding how this amplifier works, we hope to lay the foundation for new diagnostic, preventative and therapeutic strategies to ameliorate the burden of birth defect syndromes.

PI_NAMEs: ROHATGI, RAJAT  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;Adult;Amplifiers;Anabolism;beta catenin;Biochemical;Biological Process;Biology;Birth;Body System;bone;Bone Diseases;bone fragility;Bone Matrix;Bone Resorption;Calcium;causal variant;Cell Communication;cell injury;Cell Line;Cell surface;Cells;Collagen Type I;Communication;Complex;Congenital Abnormality;Congenital disorders of glycosylation;CRISPR screen;Data;Defect;Deposition;Development;Diagnostic;Disease;Endoplasmic Reticulum;Ensure;experimental study;fetal loss;Fibroblasts;Foundations;Genes;Genetic;Genetic Epistasis;Genetic study;Genome;genome wide screen;genome-wide;genomic locus;glycosylation;Goals;Homeostasis;Human;Human Development;Human Genetics;Impairment;Infant Mortality;Inherited;insight;Ligands;Link;link protein;loss of function mutation;Mass Spectrum Analysis;Measures;mineralization;Molecular;Molecular Chaperones;molecular marker;Monitor;multidisciplinary;Mutate;Mutation;novel;novel diagnostics;Organelles;osteoblast differentiation;Osteoblasts;Osteogenesis Imperfecta;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;Phosphorylation;Post-Translational Protein Processing;precise genome editing;Process;Production;protein folding;Proteins;receptor;Regenerative response;repaired;response;Role;Signal Transduction;Site;sugar;Syndrome;System;Testing;Therapeutic;Tissues;Translating;United States;WNT Signaling Pathway;Work

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: BOSTON

ORG_STATE: MA

PHR: Project Narrative In this proposal we study the role of a novel inflammatory pathway in suppressing immune regulation and promoting allograft rejection. In particular, we study an inflammatory cytokine, macrophage migration inhibitory factor (MIF), secreted by myeloid cells and alloreactive T cells during rejection and inflammation that binds CD74 (MIF receptor) on the surface of activated Tregs to dampen their function and homeostasis with opposite effect on alloreactive T cells. These finding open the possibility of CD74 based therapies in transplantation.

PI_NAMEs: AZZI, JAMIL  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;adaptive immunity;Affect;allograft rejection;Allografting;Antigens;autocrine;Binding;Biological Assay;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;ChIP-seq;Chronic;clinically relevant;Co-Immunoprecipitations;Complex;conditional knockout;cytokine;cytotoxic;Data;Dose;draining lymph node;effector T cell;Eragrostis;exhaustion;Exhibits;FDA approved;Flow Cytometry;FOXP3 gene;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;heart allograft;Heart Transplantation;Homeostasis;Human;Immune;immunoregulation;Impairment;In Vitro;in vivo;Inbred BALB C Mice;Infiltration;Inflammation;Inflammatory;insight;Interferons;IRF1 gene;isoimmunity;Luciferases;Macrophage;Mediating;Migration Inhibitory Factor;Modeling;Molecular;Monoclonal Antibodies;Mus;Myeloid Cells;Natural Immunity;novel;novel therapeutics;Organ Transplantation;Outcome;Pathway interactions;Phenotype;Play;Process;programs;Proliferating;promoter;receptor;Regimen;Regulatory T-Lymphocyte;response;Role;Signal Pathway;Signal Transduction;Solid;Specificity;Surface;T cell receptor repertoire sequencing;T memory cell;T-Lymphocyte;Tamoxifen;Techniques;Technology;Testing;Therapeutic;therapeutic target;transcription factor;transcriptomics;Transgenic Mice;translational potential;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance;Treatment Efficacy;Work

PROJECT_TITLE: The novel role of MIF-CD74 inflammatory pathway in immune regulation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Subarachnoid hemorrhage (SAH) is a type of stroke that usually results from rupture of an intracranial aneurysm. One of the most feared complications of SAH is delayed cerebral ischemia, which occurs in approximately 30- 50% of patients and is responsible for significant morbidity and mortality. This proposal uses a novel noninvasive optical instrument called pathlength resolved diffuse correlation spectroscopy to better understand the mechanisms of ischemic damages in patients with aneurysmal SAH.

PI_NAMEs: MOKIN, MAXIM  (contact);PARTHASARATHY, ASHWIN BHARADWAJ

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Acute;Aneurysm;Aneurysmal Subarachnoid Hemorrhages;Angiography;Angioplasty;blood flow measurement;Blood Pressure;Blood Vessels;Brain Ischemia;Cephalic;cerebral hemodynamics;Cerebral Ischemia;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Physiology;Cerebrovascular Spasm;Cerebrum;Clinical;Cognitive deficits;cognitive testing;Complication;Data;Deterioration;Devices;Diagnostic;diagnostic tool;diagnostic value;Diffuse;disability;Disabling;effectiveness measure;efficacy evaluation;Evaluation;Focal Neurologic Deficits;Fright;Functional disorder;functional outcomes;Health;hemodynamics;high risk;Homeostasis;Hospitalization;imaging biomarker;Impaired cognition;Impairment;indexing;individual patient;innovation;instrument;Intensive Care Units;Intervention;Intracranial Aneurysm;Ischemia;Knowledge;Length;Length of Stay;Life;Measurement;Measures;Medical;Monitor;Morbidity - disease rate;mortality;non-invasive monitor;novel;Optical Instrument;Optics;Outcome;outcome prediction;Patient Care;patient population;Patients;Perfusion;perfusion imaging;Pharmacologic Substance;Phase;Physiology;prevent;real time monitoring;Recovery;Regulation;response;Risk;Rupture;Ruptured Aneurysm;Spectrum Analysis;Stroke;Subarachnoid Hemorrhage;Syndrome;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;tool;Vasodilator Agents;Vasospasm

PROJECT_TITLE: Noninvasive monitoring of cerebrovascular regulation in subarachnoid hemorrhage.

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE These studies seek to understand how diverse elements in the fibrotic stroma of pancreas cancer impact disease progression and tumor immunity. Understanding how the pancreas cancer tumor environment regulate tumor immunity is critical to employing stromal modulatory therapy to enhance immunotherapeutics.

PI_NAMEs: DENARDO, DAVID G (contact);PROVENZANO, PAOLO

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Antigen Presentation;Architecture;Automobile Driving;Basic Science;biophysical properties;biophysical techniques;cancer cell;cancer initiation;Cell Aging;Cell Cycle Arrest;Cell Physiology;Cell Survival;Cells;Clinical;Complex;Data;Defense Mechanisms;Dendritic Cells;density;Diagnosis;Disease;Disease Progression;Elements;Environment;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Galactosidase;Genetically Engineered Mouse;Human;human tissue;Immune;Immunologic Surveillance;Immunologic Techniques;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo imaging system;Infiltration;Inflammatory;Invaded;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;mouse model;Myelogenous;Myeloid Cells;Myofibroblast;Nature;Neoplasm Metastasis;neoplastic cell;Organ;Outcome;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phenotype;Play;Property;Refractory;Research;Research Personnel;response;restraint;Role;senescence;senescent cell;Specimen;standard of care;Stromal Cells;Survival Rate;T cell infiltration;T cell response;T-Lymphocyte;therapy resistant;Tissue Model;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenesis

PROJECT_TITLE: Stomal Senescence Regulator of Tumor Immunity and Progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative: Influenza A virus (IAV) remains a critical global public health threat, responsible for an estimated 250,000- 500,000 deaths each year. This proposal aims to dissect the host and viral factors that constrain the antigenic evolution of these viruses in humans.

PI_NAMEs: BROOKE, CHRISTOPHER BYRON (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: adaptive immunity;Affect;Amino Acids;Avidity;base;Binding;Cells;Cessation of life;Circulation;Data;Development;Economic Burden;Environment;Equilibrium;Evolution;Future;Genes;Genetic;Genome;Genotype;Glycoproteins;Hemagglutinin;Herd Immunity;Human;Humoral Immunities;Immune;Immune response;improved;In Vitro;in vivo;Individual;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza vaccination;influenzavirus;Knowledge;Molecular;molecular array;Monoclonal Antibodies;Mutation;Neuraminidase;neutralizing antibody;next generation;Pathway interactions;Pattern;Phenotype;Play;polyclonal antibody;Population;pressure;Process;Proteins;Public Health;receptor;receptor binding;Resistance;RNA Viruses;Role;seasonal influenza;Seasons;Shapes;sialic acid receptor;Sialic Acids;Testing;Tissues;trend;Vaccination;vaccination strategy;Vaccines;Variant;Viral;viral fitness;Viral Hemagglutinins;Viral Physiology;Virus

PROJECT_TITLE: Dissecting the viral and host constraints that govern influenza virus antigenic evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-U (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SUNNYBROOK RESEARCH INSTITUTE

ORG_STATE: ON

ORG_ZIPCODE: M4N 3M5

PHR: Project Narrative: Despite the availability and promise of transcranial alternating current stimulation, its effectiveness at arresting memory decline has hitherto been limited and highly variable across Alzheimer’s Disease (AD) patients. Our experimental AD model studies will leverage novel approaches to cellular-level interrogation of neuronal function and relate the cellular scale changes in brain activity elicited by tACS to mesoscopic scale changes in neurotransmitter levels and flux, and working memory. We will establish multi-scale machine learning models for predicting the effects of transcranial alternating current stimulation on neuronal activity and working memory using clinic-ready neuroimaging protocols, so as to lay the foundation for development of personalized neuromodulation interventions for treating memory deficits in the early stage of AD pathology.

PI_NAMEs: GOUBRAN, MAGED ;HYDER, DEWAN SYED FAHMEED;MCLAURIN, JOANNE ;STEFANOVIC, BOJANA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;analysis pipeline;Animal Diseases;Animals;Attenuated;Behavior;behavior test;Behavioral;Biological Assay;Biological Markers;Blood flow;Brain;Cephalic;clinic ready;Cognition;cognitive performance;computational pipelines;Coupling;Data;density;Dependence;Development;Diffusion Magnetic Resonance Imaging;Disease;Effectiveness;effectiveness evaluation;Elderly;Electrodes;Electrophysiology (science);Experimental Models;Fluorescence;Fluorescence Microscopy;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Genes;graph neural network;Health;Heterogeneity;Image;Imaging Techniques;Immunization;Immunotherapy;Impairment;improved;In Situ;Individual;inhibitory neuron;Intervention;Investigation;machine learning model;machine learning prediction;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Maps;Measures;Membrane;Memory;Memory impairment;Memory Loss;Microscopic;Modeling;multimodality;neuroimaging;Neuronal Dysfunction;Neurons;neuroregulation;neurotransmission;Neurotransmitters;novel;novel strategies;Optical reporter;Pathologic;Pathology;patient population;Pattern;Periodicity;Phase;precision neuromodulation;predictive tools;Protocols documentation;Rat Transgene;Rattus;Reporting;response;Rest;sensor;Sensory;Short-Term Memory;somatosensory;spatial memory;spectroscopic imaging;Study models;tau Proteins;Technology;Testing;Time;Training;Transgenic Organisms;two-photon;Virus;voltage;Work

PROJECT_TITLE: Imaging the effects of transcranial alternatingcurrent stimulation in an experimental model of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]