ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Mental Health;Neurosciences;Rehabilitation;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Given that 75% or more of breast cancer survivors report cancer-related cognitive impairments (CRCI) that are associated with reduced functional ability and quality of life, efforts to adequately assess CRCI are critical. We aim to provide valuable knowledge that will advance the science in accurately measuring CRCI in the context of everyday life. Findings from this study will provide critical data for establishing best practices for using cognitive patient reported outcomes in CRCI research and clinical settings.

PI_NAMEs: HENNEGHAN, ASHLEY M. (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Activities of Daily Living;Address;Aftercare;Age;Anxiety;Attention;Breast Cancer survivor;Cancer Survivor;cancer-related cognitive impairment;Caring;chemotherapy;Chronic Disease;Clinical;clinical practice;clinically significant;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive process;cognitive testing;Consensus;contextual factors;Coupling;Data;Data Collection;depressive symptoms;Diagnosis;Disabling;Distress;Ecological momentary assessment;Enrollment;European Organization for Research and Treatment of Cancer;executive function;experience;Fatigue;Feeling;follow-up;Foundations;Future;Goals;Health Care Research;health management;Health Promotion;improved;individual variation;Information Systems;innovation;insight;instrument;interest;intervention effect;Intervention Studies;Knowledge;Life;Literature;Lived experience;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Memory;Mental Depression;Methodology;Methods;Monitor;National Institute of Nursing Research;Nature;Observational Study;Occupational;Outcome;Outcome Measure;outcome prediction;Patient Outcomes Assessments;performance tests;Persons;Phenotype;Precision Health;Prevention;primary outcome;processing speed;prospective;Prospective Studies;Psychometrics;Quality of life;Recommendation;reduce symptoms;Reporting;Research;Research Personnel;Sampling;Science;Self Assessment;Severities;Short-Term Memory;social;Social Functioning;Survivors;Symptoms;tertiary prevention;therapy development;Time;treatment planning;Validity and Reliability;Work

PROJECT_TITLE: Defining Cognitive Patient Reported Outcomes of Breast Cancer Survivors in the Context of Everyday Functioning and Quality of Life

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  There is strong evidence that viruses kill neural progenitor cells and impair neurogenesis through an unknown mechanism. We recently discovered that the widely used recombinant adeno-associated virus (rAAV) kills dividing neural progenitor cells and ablates adult neurogenesis. In the current proposal, we aim to uncover the cellular and molecular pathways that mediate this rAAV-induced toxicity in order to identify a universal mechanism for viral causes of neurodevelopment disorders.

PI_NAMEs: SHTRAHMAN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Adult;adult neurogenesis;Adverse effects;adverse outcome;Affinity;Apoptosis;Base Pairing;Binding;Binding Proteins;Biological Assay;Biological Models;Biology;Brain;Brain Diseases;Capsid;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Death;Cell division;Cell Nucleus;Cells;Central Nervous System Viral Diseases;Cerebral cortex;Cessation of life;Childhood;Chronic;Collection;Complex;Cytomegalovirus;dentate gyrus;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA replication fork;DNA Sequence;DNA Structure;DNA-Directed DNA Polymerase;Dose;Electroporation;Event;experimental study;first responder;gene therapy;Genes;Genome;Head;HIV;Hour;Human;immunoreaction;Impairment;In Situ Hybridization;In Vitro;in vivo;Induction of Apoptosis;Infectious Agent;Injections;Inverted Terminal Repeat;life span;Mass Spectrum Analysis;Mediating;member;Microcephaly;Molecular;Multiprotein Complexes;Mus;mutant;Mutation;Names;Nerve Degeneration;nerve stem cell;Neurobiology;neurodevelopment;neurogenesis;Neurons;Nuclear Proteins;Pathology;Pathway interactions;pharmacologic;postmitotic;Prevention;Proteins;R7 Virus;Recombinant adeno-associated virus (rAAV);Reporting;response;Risk;Rubella virus;S phase;Shapes;Simplexvirus;Single-Stranded DNA;Source;Stretching;Structure;Terminal Repeat Sequences;Testing;therapeutic target;Toxic effect;Transgenes;Tropism;Variant;vector;Viral;Viral Genome;Virus;Virus Diseases;Work;ZIKA;Zika Virus

PROJECT_TITLE: Investigating Mechanisms of Viral Impairment of Neurogenesis Using Recombinant AAV

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: JORDAN-SCIUTTO, KELLY L;METZGER, DAVID S (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adult;antiretroviral therapy;Area;Basic Science;Behavior Therapy;Behavioral;behavioral and social science;Behavioral Mechanisms;Behavioral Sciences;biobehavior;Biological;Biological Specimen Banks;Biology;Biometry;Botswana;Budgets;Caring;Characteristics;Child;Clinical;Clinical Sciences;co-infection;Cognitive Therapy;Collaborations;collaboratory;Combined Modality Therapy;Communities;community advisory board;community partners;comorbidity;cultural competence;data management;design;Development;Disease;Elderly;Epidemiology;Evidence based intervention;Faculty;Fostering;Funding;Goals;Grant;HIV;HIV Infections;HIV risk;HIV therapy;HIV/AIDS;Immune System Diseases;implementation science;improved;Incidence;Individual;Infection;Information Dissemination;innovation;Institution;International;Journals;Laboratories;Leadership;Life Cycle Stages;Link;Medical;Mental disorders;Mental Health;Mentors;Methodology;Mission;Modeling;National Institute of Mental Health;next generation;novel;novel strategies;organizational structure;Outcome;Pediatric Hospitals;Pennsylvania;Persons;Pharmacotherapy;Philadelphia;Pilot Projects;Population;Postdoctoral Fellow;Pregnant Women;Productivity;programs;Psychiatry;psychologic;recruit;Research;Research Design;Research Personnel;Research Priority;Research Training;Resource Sharing;Resources;Safety;Scientific Inquiry;senior faculty;Services;Social Sciences;substance use;success;syndemic;synergism;Talents;theories;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Penn Mental Health AIDS Research Center


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: METZGER, DAVID S (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Area;Award;Basic Science;Behavioral;behavioral and social science;Behavioral Mechanisms;Behavioral Sciences;biobehavior;Biological;Biological Sciences;Biological Specimen Banks;Budgets;Businesses;career development;Career Mobility;Characteristics;co-infection;cohesion;Collaborations;collaborative environment;collaboratory;Communication;Communities;community advisory board;community engagement;Community Outreach;comorbidity;cost;Development;diversity and inclusion;Education;Education and Outreach;Ensure;Environment;Epidemiology;Equipment and Supplies;Evaluation;experience;Fostering;Funding;Future;HIV;HIV risk;HIV therapy;HIV/AIDS;Human Resources;implementation science;improved;Incidence;Individual;Infection;Information Dissemination;innovation;interdisciplinary collaboration;International;Investments;Joints;Laboratories;Leadership;lens;Medical;meetings;Mental disorders;Mental Health;Mentors;Mission;Modeling;Monitor;National Institute of Mental Health;next generation;organizational structure;Outcome;outreach;outreach program;Participant;Pediatric Hospitals;Pennsylvania;Performance;Persons;Philadelphia;Play;Policies;Procedures;Process;programs;psychologic;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Priority;Research Support;Research Training;Resource Sharing;Resources;Role;Safety;Schools;Scientist;Series;Social Sciences;sound;Strategic Planning;Structure;synergism;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Administrative Core A


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Non-standard viral genomes generated during virus replication are critical determinants of disease severity in humans during infection with respiratory syncytial virus (RSV). Here we propose experiments to advance our understanding of the host and viral factors that determine the accumulation and activity of cbVG during RSV infection. This virus infects 100% of the human population at an early age and represents a large public health burden. The proposed studies may identify new opportunities to reduce the burden of RSV disease.

PI_NAMEs: LOPEZ, CAROLINA B. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Admission activity;Adult;Affect;Age;Anti-viral Therapy;antiviral immunity;Automobile Driving;Back;bioinformatics tool;Bronchiolitis;Catalogs;Child;Childhood;Clinical;co-infection;cohort;Complex;congenital heart abnormality;Data;demographics;Detection;Disease;Early Diagnosis;Elderly;experimental study;Failure;Funding;Gene Expression;Generations;high risk;Hospitalization;Hospitalized Child;Human;Human Metapneumovirus;Immune;Immune response;Immune system;Immunocompromised Host;In Vitro;Infection;Inflammation;Inflammatory;insight;Integration Host Factors;Investigation;Kinetics;Length;Life;Modeling;mortality;mouse model;Mus;Outcome;parainfluenza virus;Pathogenesis;pathogenic virus;Pathogenicity;Patients;Population;premature;primary outcome;Public Health;Reporting;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;respiratory virus;Retrospective cohort;Risk Assessment;Risk Factors;RNA Virus Infections;Role;Sampling;secondary outcome;Severity of illness;sex;Symptoms;Testing;Therapeutic;Time;tool;transcriptome;Vaccines;Viral;Viral Genes;Viral Genome;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Defective viral genomes in RSV pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BROWN, LILY A (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Area;Award;Behavioral;Biological;career;Caring;Collaborations;Communities;community advisory board;Concept Review;Consultations;cost;Databases;design;Development;ethnic minority population;Ethnic Population;Evaluation;falls;Funding;Funding Opportunities;Goals;Grant;HIV;HIV Seropositivity;HIV/AIDS;Improve Access;improved;Individual;Infrastructure;innovation;Investments;Journals;Lead;Leadership;Link;Manuscripts;Measures;meetings;member;Mental disorders;Mental Health;Mentors;Methodology;Mission;Monitor;National Institute of Mental Health;Online Systems;Participant;Patients;Pilot Projects;Play;Population;Process;Productivity;programs;Publishing;Quality of life;racial minority population;racial population;recruit;Research;Research Personnel;Research Priority;Role;service delivery;Services;Site;sound;success;Support Groups;System;Training;Training Activity;training opportunity;Training Support;United States National Institutes of Health;Universities;web platform;Woman;Work

PROJECT_TITLE: Developmental Core B


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Two-thirds of older adults with severe injuries are treated at non-trauma centers (under-triage), despite evidence that care at trauma centers reduces preventable deaths (lives that appropriate and timely medical care would have saved). One of the critical barriers to reducing preventable deaths after injury is the absence of interventions that improve physician decision making. The objective of this proposal is to test the real-world efficacy of video game interventions designed to promote physician use of evidence-based practices.

PI_NAMEs: MOHAN, DEEPIKA  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Academy;Accident and Emergency department;active control;Address;Affect;Aging;Agreement;Behavior;Behavior assessment;behavior change;Behavioral;Behavioral Sciences;Calibration;Caring;clinical implementation;Clinical Practice Guideline;Clinical Sciences;cognitive process;Collaborations;compare effectiveness;comparison intervention;Consolidated Framework for Implementation Research;contextual factors;continuing medical education;cost;Cues;Data;Decision Making;Detection;Development;Education;Effectiveness;effectiveness/implementation study;effectiveness/implementation trial;Emergency Department Physician;Emergency department visit;Emergency Medicine;Ensure;Evidence based intervention;Evidence based practice;Expenditure;experience;Exposure to;Failure;Feedback;follow-up;future implementation;Goals;Guidelines;Health;heuristics;hospital readmission;Hospitalization;Hour;human old age (65+);implementation efforts;implementation science;improved;improved outcome;Incidence;Independent Living;Injury;injury burden;insight;instrument;Intervention;intervention effect;Interview;Intuition;Judgment;Laboratories;Link;Literature;Maintenance;Medical;Medicare claim;Medicine;Methods;Morbidity - disease rate;mortality;multidisciplinary;novel;older adult;outreach;Pain;Paramedical Personnel;Participant;Patient-Focused Outcomes;Patients;Pattern Recognition;Persons;Physicians;pilot trial;Play;Power Sources;pressure;preventable death;programs;provider behavior;Qualitative Evaluations;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Refractory;Reporting;Research;Research Priority;Sampling;Scientist;severe injury;Source;Structure;Testing;Text;theories;therapy design;Time;Training;Trauma;trauma centers;Trauma patient;treatment as usual;Triage;trial design;Uncertainty;Variant;Video Games;videogame intervention;virtual reality simulation;Work

PROJECT_TITLE: Using video games to increase implementation of clinical practice guidelines in trauma triage

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: This HIV training grant will build upon existing research at our institutions to improve human capacity in HIV- related hematology and transfusion research in South Africa. It aims to improve the academic research stature of the Clinical Hematology division at University of Cape Town and historically disadvantaged partner institutions and to continue to strengthen the Research and Development Academy at the South African National Blood Services. Research will include studies of HIV-positive participants and blood specimens, studies of HIV cure, studies the use novel technologies to detect HIV and implementation science studies directed at HIV-related lymphoma and anemia and exclusion of HIV-infected persons from blood donation.

PI_NAMEs: JENTSCH, UTE ;MURPHY, EDWARD L (contact);VERBURGH, ESTELLE

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academy;Address;AIDS-Related Lymphoma;Anemia;antiretroviral therapy;archived data;Area;Biological Assay;Biology;Biometry;Blood;California;career;Clinical;Clinical Research;Collaborations;Country;Data;Data Analyses;design;Disadvantaged;Doctor of Philosophy;doctoral student;Education;Enrollment;Epidemic;Funding;Goals;Grant;Health;Health Sciences;Health Services Research;Hematological Disease;Hematologist;Hematology;HIV;HIV therapy;Human immunodeficiency virus test;Incidence;Inequity;Institution;International;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;National Heart, Lung, and Blood Institute;Needs Assessment;next generation;novel;outreach;Patients;Preparation;Prevalence;programs;Protocols documentation;Publications;Publishing;Recording of previous events;Registries;Research;research and development;Research Design;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;San Francisco;Schools;Services;skills;South Africa;South African;Specimen;Time;Training;Training Activity;Transfusion;transfusion medicine;Universities;Update;Vascular blood supply;Work

PROJECT_TITLE: Blood Research and EnhAnced Training against HIV in South Africa (BREATH-SA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative  Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview-based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: GOLD, JAMES M. (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;computerized;Computing Methodologies;design;Detection;Deterioration;Diagnosis;Dimensions;Early Diagnosis;Early identification;Early Intervention;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;Modeling;neural;Neurobiology;new therapeutic target;next generation;online delivery;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Psychopathology;Psychoses;psychosis risk;psychotic symptoms;Public Health;Publishing;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Sample Size;screening;Secondary Prevention;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: 1/5 CAPER: Computerized Assessment of ProdromE Risk


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Patient Safety;Prevention;Social Determinants of Health

PI_NAMEs: GIBBONS, MARY BETH  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Advisory Committees;Anti-Retroviral Agents;Area;Awareness;Behavior assessment;Behavioral;Calibration;Cellular Phone;Characteristics;Clinical;Clinical assessments;Clinical Research;Collaborations;computerized;Confidentiality of Patient Information;Consult;Consultations;cost;cost effective;Data;Data Collection;Databases;design;Development;Diagnosis;Diagnostic;diagnostic platform;digital phenotyping;Disease;Ecological momentary assessment;Ethics;Ethnic Origin;Evaluation;Exclusion;experience;Extramural Activities;Feedback;functional status;Funding;Gender;Grant;Health Technology;Heterogeneity;HIV;HIV-associated neurocognitive disorder;HIV/AIDS;Human Resources;human subject;Hylobates Genus;Individual;Informed Consent;innovation;Interview;Interviewer;Knowledge;Measures;Medical;medication compliance;Mental Depression;Mental Health;method development;mHealth;Mission;Monitor;Neurocognitive;Neuropsychology;Participant;patient safety;Patient Self-Report;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Procedures;Process Assessment;Psyche structure;psychiatric emergency;psychiatric symptom;psychologic;Published Comment;Race;recruit;Research;Research Personnel;Resource Sharing;Resources;Risk Assessment;Role;Sample Size;Sampling;screening;Services;Severities;skills;social;social health determinants;Suggestion;suicidal risk;Training;Withdrawal

PROJECT_TITLE: Clinical Assessment Core C


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Anti-cancer drugs and environmental chemicals elevate irreversible protein trapping in DNA, inducing a DNA damage response and mutagenesis if not repaired properly. The proposed research examines the key steps in cellular mechanisms that eliminate trapped proteins in DNA and thereby prevent the development of several motor neuron diseases and therapeutic resistance in breast and ovarian cancers.

PI_NAMEs: LEE, SANG EUN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;adduct;Aging;Alleles;anti-cancer;Antineoplastic Agents;APEXL2 Gene;Base Excision Repairs;Binding Proteins;Biochemical;Biochemical Genetics;Biochemistry;Biological;Biological Assay;Biological Models;Biological Process;BRCA deficient;BRCA1 gene;BRCA2 gene;Camptothecin;cancer cell;Cell Death;Cell Physiology;Cells;Chemicals;Chromatin;Collaborations;Complex;crosslink;Deoxyribonucleases;Development;Disease;Disease Resistance;DNA;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-(apurinic or apyrimidinic site) lyase;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;DNA-protein crosslink;environmental chemical;Environmental Pollutants;Enzymes;Etiology;Excision;Exposure to;Formaldehyde;Foundations;Gene Expression;Genetic;genetic approach;Genetic Recombination;Genome;Genomic Instability;Genomics;Growth;Histones;Homologous Gene;homologous recombination;Human;human disease;innovation;inorganic phosphate;Interruption;Investigation;Laboratories;Lymphopoiesis;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of ovary;Modeling;Molecular Genetics;Motor Neuron Disease;Movement;multicatalytic endopeptidase complex;Mus;Mutagenesis;mutant;Mutation;Nerve Degeneration;nuclease;Nucleotide Excision Repair;Nucleotides;Pathway interactions;Patients;Peptide Hydrolases;Peptides;Periodicity;Physiological;prevent;Process;Property;protein complex;Proteins;Proteolysis;Reaction;receptor;reconstitution;Regulation;Repair Complex;repaired;Repetitive Sequence;Research;Resistance;response;Ribonucleotides;Role;seal;Single Strand Break Repair;Stress;Symptoms;Tail;Technical Expertise;Testing;Therapeutic;therapy resistant;Topoisomerase;Toxin;Type I DNA Topoisomerases;Tyrosine;Ubiquitin;Ubiquitination;Yeasts

PROJECT_TITLE: Repair of DNA ends with adducts

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: WILSON, JACQUELINE DEANNA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive intervention;Address;Adherence;AIDS prevention;Applications Grants;Area;Attention;Behavior;Behavior Therapy;Behavioral;Behavioral Sciences;biobehavior;Biological;Biological Assay;Clinical assessments;Clinical Treatment;Collaborations;collaboratory;Communities;community advisory board;community based participatory research;community engagement;community partners;community setting;comorbidity;comparative effectiveness;Comparative Effectiveness Research;comparison group;Complex;Consultations;cost effectiveness;cost-effectiveness evaluation;Dedications;design;Detection;Development;evidence base;Evidence based intervention;Evidence based practice;experimental study;Funding;Goals;Grant;health economics;Health Personnel;Health Policy;HIV;HIV risk;HIV Vaccine Trials Network;Home;Human Resources;implementation science;Individual;innovation;interest;Intervention;Intervention Studies;investigator training;Joints;Knowledge;Laboratories;Leadership;Libraries;Link;Manuals;Medical;medication compliance;Medication Management;Mental disorders;Mental Health;Methodology;Methods;Mission;Monitor;Outcome;outreach;Patient Recruitments;Patients;Persons;pharmacologic;Philadelphia;Pilot Projects;Policies;Population;preference;Preparation;Provider;psychiatric comorbidity;Psychiatric therapeutic procedure;psychologic;Psychotherapy;Public Health;Public Policy;Quality of Care;Quasi-experiment;randomized, clinical trials;recruit;Research;Research Methodology;Research Personnel;research study;Resources;Risk Behaviors;Schools;Services;Signal Transduction;skills;Standardization;Supervision;Support Groups;syndemic;Testing;Time;Training;translational impact;Translational Research;treatment comparison;Treatment Effectiveness;Treatment Protocols;Universities

PROJECT_TITLE: Community Engagement Core D


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE; PUBLIC HEALTH RELEVANCE STATEMENT The present study aims to provide insight on the effects of minority stress, affect, and sociocultural protective factors on Hispanic and white sexual minority youth’s (SMY) use of alcohol. The study will test whether the double jeopardy or resiliency hypothesis predict use of alcohol and the sociocultural protective factors that explain the differences between Hispanic and white SMY alcohol use. Findings will help to identify risk of alcohol use among SMY and the protective factors that could be leveraged in treatment to help address problematic drinking.

PI_NAMEs: ROSALES, ROBERT  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Alcohol abuse;Alcohol consumption;alcohol poisoning;alcohol risk;alcohol tobacco and other drug use;Alcohols;assault;ATOD;Attitude;Award;Behavior;binge drinking;cancer risk;career development;children of color;cognitive interview;contextual factors;coping;Coping Skills;cultural values;Data;Data Analyses;Development;Discrimination;drinking;drug misuse;Ecological momentary assessment;ethnic identity;Ethnic Origin;ethnoracial minority;Event;experience;Exposure to;Face;Family;Goals;Heterosexuals;high risk;high risk drinking;high risk sexual behavior;Hispanic;Homophobia;Individual;innovation;insight;Intervention;K-Series Research Career Programs;Language;Literature;marginalization;Measures;Mediating;Mentors;Mentorship;Methodology;Methods;Minority Status;minority stress;National Institute on Alcohol Abuse and Alcoholism;negative affect;Not Hispanic or Latino;Participant;Patient Recruitments;Perception;Phase;Pilot Projects;positive youth development;Predictive Factor;promote resilience;protective factors;psychological distress;Public Health;public health relevance;Qualitative Methods;racism;Research;resilience;resilience factor;response;Risk;Risk Factors;sexual minority;sexual minority health research;sexual minority youth;social culture;social stressor;Social support;Source;Statistical Data Interpretation;Stigmatization;Stress;stressor;substance use;Suicide;Suicide attempt;Testing;theories;Time;Training;underage drinking;Underserved Population;United States National Institutes of Health;Vehicle crash;Youth

PROJECT_TITLE: Socio-Cultural Protective and Risk Factors of Alcohol Use among Non-Hispanic White and Hispanic Sexual Minority Youth


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative This project is a multicenter, randomized, double-masked, placebo-controlled clinical trial designed to test the hypothesis that oxidative damage is a major contributor to cone cell death in retinitis pigmentosa (RP) and that long-term oral N-acetylcysteine will promote cone survival and reduce severe visual disability. It has the potential to provide a treatment that applies to all patients with RP regardless of the causative mutation and help to maintain visual function and reduce severe disability. It will also answer the scientific question, to what extent does oxidative damage contribute to cone cell death in RP and is it a target for the development of additional treatments.

PI_NAMEs: CAMPOCHIARO, PETER A (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Acetylcysteine;adaptive optics;adaptive optics scanning laser ophthalmoscopy;Address;Affect;Age;Animal Model;Antioxidants;Area;Biological Markers;Blindness;Caring;causal variant;Cause of Death;Cell Death;Cells;Cessation of life;Clinical Research;Clinical Trials;Clinical Trials Design;comparative efficacy;Cone;constriction;Consumption;Controlled Clinical Trials;Data;density;Development;Diabetic Retinopathy;disability;Disease;Dose;Early treatment;effective therapy;efficacy testing;evidence base;experience;Eye;Feasibility Studies;fovea centralis;functional outcomes;Future;gene therapy;Genes;genome sequencing;genomic data;Genotype;Goals;Grant;group intervention;Health;improved;Individual;inherited retinal degeneration;Intervention Trial;Laboratories;Legal patent;Light;macula;Masks;Maximum Tolerated Dose;Measures;Medical;meter;Methodology;Mission;mosaic;mouse model;Mutation;National Eye Institute;Natural History;new therapeutic target;NIH Program Announcements;non-invasive imaging;novel;Ophthalmoscopy;Optical Coherence Tomography;Optics;Oral;oral supplementation;Outcome;Outcome Assessment;Outcome Measure;oxidative damage;Oxidative Stress;Oxygen;Participant;Pathogenicity;Patient Outcomes Assessments;Patients;Perimetry;Pharmacogenomics;Phase;Phase I Clinical Trials;photoreceptor degeneration;Placebo Control;placebo group;Placebos;Play;Population;prevent;primary outcome;programs;Protocols documentation;Randomized;randomized placebo controlled trial;Reading;Recording of previous events;Research Personnel;Research Project Grants;Research Proposals;Resolution;Resources;response;Retina;Retinal Cone;retinal rods;Retinitis Pigmentosa;Rod;Role;Safety;Sample Size;Sampling Studies;Scanning;sex;Site;Smoking Status;Subgroup;Symptoms;Testing;therapeutic target;therapy development;Time;tomography;treatment duration;Treatment Efficacy;treatment group;Vision;Visual;Visual Acuity;Visual disability;Visual Fields;whole genome;Width

PROJECT_TITLE: NAC Attack, A Phase-3, Multicenter, Randomized, Placebo-Controlled Trial in Patents with Retinitis Pigmentosa


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Prevention

PI_NAMEs: JORDAN-SCIUTTO, KELLY L (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;arterial spin labeling;Autoimmunity;behavior test;Behavior Therapy;Behavioral;Big Data;biobank;biobehavior;Biochemical Markers;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker identification;biomedical informatics;Biometry;blood oxygen level dependent;Body Fluids;bone;brain behavior;Cardiovascular system;Cells;Cerebrovascular Circulation;Clinical;Clinical assessments;Clinical Data;Cognitive;cohort;Collaborations;comorbidity;computerized;computerized data processing;Data;data management;Data Set;Databases;design;Development;Diffusion;Disease;Dopamine;Emotions;Functional Magnetic Resonance Imaging;Funding;Genomic DNA;Genotype;Gur;Health;HIV;HIV Infections;HIV/AIDS;Image;immune activation;Immune response;Immunity;Immunosuppression;Immunotherapy;Inflammation;Intervention;Intervention Studies;Jordan;Kidney;Laboratories;laboratory experiment;Leadership;Link;Magnetic Resonance Imaging;Measurement;Measures;Medical;medical schools;Mental disorders;Mental Health;Metabolic;metabolomics;microbiome;Mission;Modeling;Molecular Virology;Monitor;Morbidity - disease rate;Nervous System Disorder;neuroAIDS;Neurocognitive;neuroimaging;Neuropsychology;novel;Outcome;Output;participant enrollment;Pathway interactions;Pediatric Hospitals;Pennsylvania;Persons;pharmacologic;Phenotype;Philadelphia;Physiological;Pilot Projects;Plasma;Population;Positioning Attribute;Positron-Emission Tomography;programs;Psychiatry;Public Health Informatics;quality assurance;Quality Control;Records;repository;Research;Research Personnel;Resources;Rest;Rewards;Role;Sampling;Schools;Sensory Receptors;Serotonin;Serum;single photon emission computed tomography;Specimen;Standardization;Stress;Techniques;Technology;Testing;Therapeutic;transcriptome sequencing;Universities;Viral;Work

PROJECT_TITLE: Laboratory & Biobehavioral Marker Core E


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Heart failure is the leading cause of death in industrialized societies. Our research studies the critical role of membrane abnormalities during heart failure. We have discovered new pathways that generate toxic molecules promoting the progression cardiac compromise. The proposed research is directed toward identifying several levels of new targeted approaches for the treatment of heart disease.

PI_NAMEs: GROSS, RICHARD W (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 12-HETE;Ablation;Address;Arachidonate 12-Lipoxygenase;Arachidonate 15-Lipoxygenase;Attenuated;beta-Hydroxybutyrate;Binding;Bioenergetics;Cardiac;Cardiac Myocytes;Cardiolipins;Cardiovascular Diseases;Cardiovascular system;Carnitine;Cause of Death;Cell Death;cell type;Cells;cellular targeting;Chemicals;Chemistry;chemoproteomics;Citric Acid Cycle;Complex;Congestive Heart Failure;CRISPR/Cas technology;cyclooxygenase 2;cytochrome c;cytokine;Derivation procedure;Developed Countries;diagnostic signature;Eicosanoids;Endothelial Cells;Environment;Enzymes;experimental study;Female;Fibroblasts;Free Radicals;Functional disorder;Future;G-Protein-Coupled Receptors;Generations;Glutathione Disulfide;Grant;Heart;Heart Diseases;Heart failure;Heart Mitochondria;Human;Hydrolysis;Hydroxyeicosatetraenoic Acids;Immune system;Incubated;Industrialization;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;interest;Iron;Iron Chelation;Ketone Bodies;Knowledge;Label;Ligands;lipid mediator;lipid metabolism;Lipid Peroxides;lipidome;Lipids;Lysophosphatidylcholines;Lysophospholipids;Macrophage;male;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;monocyte;Myocardial Ischemia;Myocardium;NADP;novel;Oxidases;oxidation;Oxidation-Reduction;Oxidative Stress;oxidized lipid;Palmitates;Parents;Pathway interactions;Phospholipases A;Phospholipids;Plasmalogens;Play;polyunsaturated fat;Predisposition;Production;protein complex;Proteins;Publishing;Pyruvate;Reaction;Reactive Oxygen Species;receptor;Research;research study;Resolution;Respiration;response;Role;Signal Transduction;Societies;Specificity;stable isotope;Stress;Substrate Cycling;Succinates;targeted treatment;Technology;ubiquinol;Ubiquinone;women subjects

PROJECT_TITLE: Novel Lipid 2nd Messengers Regulating Bioenergetics and Signaling in Human Myocardium

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal seeks to develop a new molecular strategy to limit subretinal fibrosis in blinding eye disease. Adenosine receptor 2A (Adora2a) is expressed in choroidal endothelial cells and macrophages and contributes to their transitions to mesenchymal cells and myofibroblasts. The proposed studies are designed to use Adora2a deficient cells and mice to investigate the involvement of different cellular Adora2a in subretinal fibrosis and to define the underlying mechanisms.

PI_NAMEs: CALDWELL, RUTH B;HUO, YUQING  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Actins;Adenosine;Anatomy;Angioblast;Blood Vessels;Bone Marrow;cell type;Cells;Choroidal Neovascularization;Cicatrix;Data;design;Development;Endothelial Cells;Endothelium;Epithelial Cells;Exudative age-related macular degeneration;Eye diseases;Fibrosis;Genetic;Hypoxia Inducible Factor;Hypoxia-Inducible Factor Pathway;In Vitro;in vitro Model;in vivo;Infiltration;Inflammatory;inhibitor;Lasers;Lesion;Macrophage;Mediating;Mesenchymal;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;Myofibroblast;Neuroglia;novel strategies;novel therapeutic intervention;overexpression;Oxygen;Pathologic;Patients;pharmacologic;Prevention;Production;Profibrotic signal;Purinergic P1 Receptors;Receptor Signaling;Retina;retinal angiogenesis;Retinal Diseases;Role;Signal Transduction;Smooth Muscle;Snails;Structure of retinal pigment epithelium;Testing;Therapeutic;tool;transcription factor;Transforming Growth Factor Beta 2;Vascular Diseases;Vascular Endothelial Growth Factors;vascular inflammation;Visual impairment

PROJECT_TITLE: Adenosine receptor 2A in subretinal fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: MORALES, KNASHAWN HODGE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animals;Award;Basic Science;Behavioral;Behavioral Mechanisms;Bioinformatics;Biological;Biological Assay;Biological Markers;Biometry;Bipolar Disorder;Cellular Phone;Characteristics;Clinical assessments;clinical biomarkers;clinical center;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Community Health;comorbidity;Computerized Medical Record;Data;Data Collection;data management;Data Reporting;data repository;design;Development;Disease;electronic data;Faculty;Family Practice;Funding;Genetic;Goals;Grant;HIV;Human Resources;improved;Individual;innovation;Intervention;Intervention Studies;Investigation;Laboratories;Medical;medical schools;Mental Health;Mental Health Services;Methodology;Methods;mHealth;Mission;mobile application;Modeling;National Institute of Mental Health;novel;Outcome;Patient Self-Report;Patients;Pediatric Hospitals;Personal Satisfaction;Philadelphia;Pilot Projects;Population;population health;Preparation;Preventive;prognostic;psychologic;Qualitative Methods;Qualitative Research;Regimen;Relapse;Research;Research Design;Research Methodology;Research Personnel;Resources;Schizophrenia;sensor;Statistical Methods;Symptoms;Therapeutic;wearable data;Work

PROJECT_TITLE: Biostatistics and Data Management Core F


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PASADENA

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Cross-coupling reactions enable the construction of new C–X bonds (X = C, N, O, F, etc.) necessary for the synthesis of existing pharmaceuticals and new drug candidates. While precious metal Pd-based catalysts are largely used on an industrial scale, the combination of the disparate electron transfer properties of earth abundant first row transition metal catalysts and the possibility of harnessing light energy to generate uniquely reactive electronic states represents an attractive, sustainable approach to accessing new mechanistic possibilities for drug synthesis and discovery. Using a combined spectroscopic and computational approach, the objective of this proposal is to define the critical electronic structure contributions to ground state Cu- and Ni-catalyzed cross-couplings and to further use and develop time-resolved spectroscopies to elucidate key excited state factors that allow for sustainable light-driven syntheses of molecular therapeutics.

PI_NAMEs: HADT, RYAN G (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: absorption;Adopted;Calibration;Catalysis;catalyst;circular magnetic dichroism;Computing Methodologies;Coupling;Development;Disparate;drug candidate;drug discovery;drug synthesis;Electron Transport;electronic structure;Electronics;emission spectroscopy;Engineering;Evolution;frontier;geometric structure;Industrialization;Industry;knowledge base;Ligands;Light;magnetic field;metal complex;Metals;Methodological Studies;Methods;Molecular;molecular orbital;Nature;novel therapeutics;Optics;Pathway interactions;Pharmaceutical Chemistry;Pharmacologic Substance;Photochemistry;photonics;Planet Earth;Potential Energy;Process;Property;Reaction;Relaxation;Research;Rest;Roentgen Rays;Spectrum Analysis;Structure;success;Surface;Temperature;Therapeutic;Time;Transition Elements;Translations;Work

PROJECT_TITLE: Understanding Geometric and Electronic Structure Contributions to Ground and Excited State Cu- and Ni-Catalyzed Cross-Coupling Reactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(07)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE: OVERALL - Center for Native Environmental Health Equity Research Indigenous communities in the US experience substantially higher rates of chronic diseases and an ever- increasing prevalence of cancer compared to the US population overall with decades of industrial mining, in these communities that rely heavily on natural resources resulting in disparately greater exposures to the waste from 161,000 abandoned hard rock mines remaining within 10km of 600,000 tribal members. Disparities in solid waste infrastructure and continued use of low-temperature burning results in incomplete combustion of ever-increasing amounts of plastics in the waste stream now adds exposure concerns due to microplastics and other plastic degradation products that now combine with and exacerbate the metals exposures, further increasing risks for cancer and other chronic diseases. This Center will identify these emerging tribal contaminants and evaluate exposure:disease relationships to develop mitigation strategies.

PI_NAMEs: HOOVER, JOSEPH HAMILTON;LEWIS, JOHNNYE L;MACKENZIE, DEBRA  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Affect;Air;Animals;Arsenic;Autoimmunity;Biological;cancer health disparity;cancer risk;Cells;Chemicals;Cheyenne;Chronic Disease;cold temperature;Communication;Communities;community building;community engagement;Community Participation;community partners;Complex;Consultations;Consumption;cooking;Crow Tribe;Crows;Custom;Data Collection;design;Diet;Disease;disease disparity;disorder prevention;Disparity;distrust;drinking water;Early identification;Environment;environmental disparity;Environmental Health;Equity;experience;exposed human population;Exposure disparity;Exposure to;Food;Food Chain;Genetic;Genetic Research;Geography;Goals;Health;health disparity;Health equity research;Heating;Home;Human;immune function;Immune System Diseases;Indigenous;indigenous community;Individual;Industrialization;Industry;Infrastructure;Ingestion;Inhalation;Intervention;Language;Life Style;Link;Livestock;Malignant Neoplasms;Manganese;meetings;member;mentoring community;Metal exposure;Metals;migration;Mining;mobile sensor;Modeling;Modification;Monitor;Native American population;Native Americans;Natural Resources;Navajo;Outcome;outcome disparities;Pathway interactions;Pattern;Persons;Phase;Plants;Plastics;Policies;Population;predictive modeling;Prevalence;Prevention strategy;Probability;Process;Recording of previous events;Refuse Disposal;Research;Research Design;Resources;Risk;risk mitigation;Route;Rural Community;Science;Services;Sioux Indians;Site;Solid;Solid Waste Disposals;Source;Stream;Surveys;Time;toxicant;tribal community;tribal member;Tribes;Uncertainty;United States;Uranium;volatile organic compound;Waste Management;wasting;Water;Work

PROJECT_TITLE: Center for Native American Environmental Health Equity Research


NIH_SPENDING_CATS: Aging;Clinical Research;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Primary open angle glaucoma is a complex chronic disease that affects over 2.9 million people in the United States and is the 2nd leading cause of blindness in this country. Clinical decision making for glaucoma is challenging, as clinicians must incorporate large amounts of longitudinal data from many data sources, which often results in suboptimal testing and management. This study will lead to the development of a standards- based clinical decision support system that presents data at the point of care to help clinicians determine a personalized frequency for visual field testing for patients with glaucoma, which will reduce over- and under- testing and ultimately prevent vision loss.

PI_NAMEs: STAGG, BRIAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;Biometry;Blindness;career;career development;Caring;Characteristics;Chronic;Chronic Disease;Clinic;Clinical;clinical decision support;Clinical Decision Support Systems;clinical decision-making;Clinical effectiveness;clinical encounter;clinical practice;Cognitive;cognitive task;Complex;Country;Data;Data Science;Data Sources;Decision Making;Decision Support Systems;design;Development;Development Plans;Early identification;effectiveness-implementation randomized trial;efficacy evaluation;efficacy testing;Environment;Ethnography;Evaluation;experience;Eye;Eye diseases;Face;Fast Healthcare Interoperability Resources;Fellowship;field study;Frequencies;Future;General Practitioners;Glaucoma;Goals;Grant;Health;health care delivery;Health Care Research;health information technology;Health Services Research;Human;implementation research;improved;indexing;individual patient;innovation;Institution;interoperability;Interview;iterative design;Knowledge;Laboratories;Lead;Leadership;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Michigan;Modeling;Ophthalmologist;Ophthalmology;Optometrist;Outcome Measure;Patient Care;Patients;Periodicals;Persons;point of care;pre-clinical;preclinical efficacy;predictive modeling;pressure;prevent;Primary Open Angle Glaucoma;professor;prototype;Public Health Informatics;randomized trial;Recommendation;Research;Research Personnel;Residencies;Site;Specialist;Statistical Models;support tools;System;Technology;Testing;theories;Time;Training;United States;United States National Aeronautics and Space Administration;Universities;usability;Utah;Vision;Visual Fields;Workload;Writing

PROJECT_TITLE: Improving Glaucoma Care Using a Scalable Decision Support System


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MACKENZIE, DEBRA  (contact)

PROJECT_TERMS: Address;Affect;Air;Annual Reports;career development;Cheyenne;Communication;Communities;community partners;comparative;complex data;Crow Tribe;Crows;Data;data acquisition;data management;Data Set;Development;Disparity;drinking water;Ensure;environmental disparity;Environmental Health;environmental health disparity;Epidemiologist;Equity;Evaluation;evidence base;experience;Exposure disparity;Fostering;Funding;Goals;Health;health disparity;health equity;Health equity research;Health Personnel;Immunologist;improved;insight;Institution;Institutionalization;Leadership;member;Montana;Native American community;Native Americans;Navajo;New Mexico;operation;particle;Prevention strategy;Program Development;programs;Regulation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Reservations;resilience;resilience factor;Resource Allocation;Resources;Risk Factors;Risk Reduction;Scientist;Sioux Indians;social health determinants;Source;Standardization;Structure;synergism;Time;toxicant;Translations;tribal community;tribal leader;Tribes;Trust;United States National Institutes of Health;Universities;Waste Products;wasting;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ERDEI, ESTHER  (contact)

PROJECT_TERMS: Accreditation;Address;Affect;Air;artist;Biological;Chemical Exposure;Cheyenne;Chronic;Chronic Disease;citizen science;Collaborations;Collection;college;Communication;Communities;community collaboration;community college;community engagement;community partners;community research;Complex;contaminated water;Crows;Data;Development;Diné Nation;Disparity;Education;Engineering;Ensure;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Monitoring;environmental toxicology;Epidemiologist;experience;Food;Fostering;Frequencies;Goals;Health;health equity;Health equity research;health literacy;Heavy Metals;Horns;Imagery;Immunologist;improved;Indigenous;Infrastructure;intergenerational;Knowledge;Link;literacy;Location;Metal exposure;Metals;Monitor;Montana;Multimedia;Native Americans;Navajo;outcome disparities;outreach;Paint;Pathway interactions;Patient Recruitments;Pilot Projects;Plants;Plastics;Process;programs;Quality Control;Research;research data dissemination;Research Personnel;Research Project Grants;Research Support;residence;resilience;resilience factor;response;Risk;Rural;Sampling;Scientist;Series;Sioux Indians;social determinants;social health determinants;social stressor;Soil;Solid;Source;Surveys;Symbolism;symposium;Teton Sioux Indian;Toxic effect;toxicant;Translating;translational approach;Translations;tribal community;tribal lands;Tribes;Universities;wasting;webinar;Work;wristband

PROJECT_TITLE: Community Engagement and Dissemination Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This decade has seen an explosive, devastating epidemic of opioid use disorder (OUD) in the U.S. Yet few treatments for OUD have emerged from neuroscience, perhaps in part due to a failure of conventional rodent models to capture fundamental behavioral aspects of the disorder. Using state of the art tools for manipulating and determining activity within brain circuits and networks during translationally-relevant behaviors in rats, we determine the specific roles of GABAergic ventral pallidum neurons in OUD-like behaviors, thus potentially opening new therapeutic avenues to treat addiction.

PI_NAMEs: MAHLER, STEPHEN VINCENT (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;American;Animal Model;Animals;Attention;Behavior;Behavior Disorders;Behavioral;Brain;Chronic;cocaine relapse;Cues;Dangerousness;Darkness;Data;Desire for food;Disease;drug action;Drug usage;Economics;Elasticity;Essential Drugs;experience;Failure;fentanyl analog;gamma-Aminobutyric Acid;Genetic;genetic manipulation;Globus Pallidus;Habenula;Half-Life;hedonic;Heroin;heroin use;Human;Individual;Intervention;Knowledge;Lateral;Learning;Life;Measures;Mediating;Modeling;motivated behavior;Motivation;neural network;Neurons;Neurosciences;novel therapeutics;Occupations;Opiate Addiction;Opioid;opioid epidemic;opioid use disorder;Output;Pathway interactions;Performance;Pharmaceutical Preparations;Play;Positioning Attribute;Pre-Clinical Model;preclinical study;Process;Psychological reinforcement;Punishment;Rat Transgene;Rattus;Relapse;remifentanil;Rewards;Rodent;Rodent Model;Role;Scourge;segregation;Shock;Side;stem;Symptoms;Testing;tool;treatment strategy;Ventral Tegmental Area;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Ventral Pallidum Circuits Underlying Preclinical Models of Opioid Addiction

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Cheyenne;Collaborations;Communities;community partners;Development;Dioxins;Environment;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;Environmental Pollutants;Exposure disparity;Exposure to;Funding Opportunities;Goals;greenhouse gases;Health;Health Disparities Research;health disparity;health disparity populations;Health equity research;Human;Infrastructure;innovation;Institution;Knowledge;Livestock;member;Mentors;Metals;Mission;Native American community;Native Americans;Navajo;Plants;Plastics;programs;promote resilience;recruit;Reduce health disparities;Research;Research Personnel;Research Proposals;Research Training;Resources;Sioux Indians;Spirituality;success;tribal community;tribal lands;Tribes;volatile organic compound;Waste Management;wasting;Work

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Human Genome;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Approximately 200,000 new cases of ovarian cancer (OC) occur per year worldwide, but the overall survival of OC has not significantly changed for decades. Therapies targeting host immune cells to destroy cancer cells have shown great promise in many tumor types, but thus far most OC patients have failed to respond. This project will determine how P53, which is mutated in nearly 100% of the most common OC subtype, affects epigenetic regulation of repetitive elements in OC to activate immune cells against tumors, informing future epigenetic and immune therapies against this deadly disease.

PI_NAMEs: CHIAPPINELLI, KATHERINE B (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;anti-PD-1;Antigen Presentation;antigen-specific T cells;Antigens;Apoptosis;Basic Science;Binding;Binding Sites;cancer cell;Cancer cell line;Cancer Patient;cancer subtypes;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Cycle Regulation;Cell Line;cell type;Cells;Chromatin;chromatin immunoprecipitation;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Data;demethylation;Disease;DNA Binding Domain;DNA Methylation;Double-Stranded RNA;Engineering;Epigenetic Process;epigenetic regulation;epigenetic therapy;Exhibits;Future;gain of function;Genes;Genetic Transcription;Histone Deacetylase Inhibitor;Human;Human Genome;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune signaling;Immune system;Immunosuppression;Immunotherapy;immunotherapy clinical trials;improved outcome;Infiltration;inhibitor;innovation;Interferons;Libraries;Lymphocyte;Malignant neoplasm of ovary;Malignant Neoplasms;Methylation;Missense Mutation;Modification;mouse model;mutant;Mutate;Mutation;neoantigens;novel;novel therapeutics;Oncogenic;Outcome;Patients;Peptides;prevent;Primary Neoplasm;Production;Proteins;Proteomics;Publishing;recruit;Regulation;Repetitive Sequence;Research;response;Role;Sampling;Serous;Signal Transduction;T cell response;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;TP53 gene;Transcript;Transcriptional Regulation;Transcriptional Silencer Elements;transcriptome sequencing;Translating;tumor;Tumor Antigens;Tumor Burden;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Regulation of repetitive elements in cancer by P53 and epigenetic mechanisms

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Our long-term goal is to eliminate inequities in birth outcomes for black women. This timely and urgent project not only aligns with NICHD’s goal of preventing pregnancy-related complications and reducing maternal and infant death but will further underscore the negative impact of racialized police violence on society, bolstering arguments for large-scale change in police-community interactions. This study also marks an important change in public health framing from one that incorrectly names race—a seemingly immutable characteristic—as a “risk factor” to one that centers racism as a fundamental cause of health inequities.

PI_NAMEs: HARDEMAN, RACHEL R (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Acute;adverse birth outcomes;Age;Belief;Birth;Birth Records;Black American;black men;black women;Caucasians;Cessation of life;Characteristics;Charge;Child;Cities;Cohort Studies;Communities;County;Crime;Data;Death Rate;Discrimination;Distal;early childhood;Event;experience;Family;Fostering;Goals;Health;health inequalities;Improve Access;Incidence;Inequity;Infant;Infant Mortality;Intervention;Interview;killings;Link;Lived experience;Low Birth Weight Infant;Maternal and Child Health;Maternal Mortality;maternal stress;Medical;Minnesota;Names;National Institute of Child Health and Human Development;Neighborhoods;novel;Outcome;Pathway interactions;Pattern;Persons;Police;Population;population based;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;Prenatal care;prevent;Psychosocial Assessment and Care;Psychosocial Stress;Public Health;public health research;Quasi-experiment;Race;racial disparity;racism;Records;Reporting;reproductive;Reproductive Health;reproductive outcome;Research;Resources;Risk;Risk Factors;Site;social;Societies;Source;Stress;stressor;Structural Racism;Surveys;System;Testing;Twin Cities;Violence;White Women;Woman

PROJECT_TITLE: Community Events and Pathways to Inequities in Birth Outcomes

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: GONZALEZ ESTRELLA, JORGE  (contact)

PROJECT_TERMS: Address;Air;Attention;Biophysics;Burn injury;Carbon Dioxide;Carbon Monoxide;Cellular Structures;Characteristics;chemical property;chemical release;Chemicals;Chemistry;Cheyenne;combustion product;Communities;community partners;Crow Tribe;Crows;Dioxins;Disparity;Ecosystem;Environment;environmental disparity;Environmental Health;Environmental Pollution;experimental study;exposure pathway;Exposure to;Fire - disasters;Food;Gases;Generations;Goals;greenhouse gases;Hand;Health;Health equity research;Heavy Metals;Human;Hydrogen Sulfide;Infection;Infrastructure;insight;Investigation;laboratory experiment;Mechanics;Medicine;Methodology;Microbe;Microscopy;Monitor;monomer;Morphology;Native Americans;Navajo;Odors;Particulate Matter;Pathway interactions;Pattern;Personal Communication;Photosynthesis;physical property;Plague;plant growth/development;Plant Roots;Plants;Plastics;Poison;Pollution;Practice Management;Process;Reaction;Refuse Disposal;Research Project Grants;Risk;Role;Sampling;Silicones;Sioux Indians;Site;Soil;Solid;Spectrum Analysis;Surface;Symbiosis;System;Testing;tool;Toxic effect;transmission process;tribal community;tribal lands;Tribes;volatile organic compound;Waste Management;wasting;Water;water vapor;Wildfire;wristband

PROJECT_TITLE: Role of open dumping and open burning of solid waste in the generation of microplastics and products of incomplete combustion on tribal lands


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This research program will use genetics and genomics to understand how organisms evolve extreme traits and alter mechanisms governing inheritance. Examining natural variation in wild relatives of the laboratory mouse will illuminate common human diseases ranging from the metabolic syndrome to chromosomal birth defects.

PI_NAMEs: PAYSEUR, BRET A (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Body Size;Cell Physiology;Cells;Complex;Congenic Strain;Congenital Abnormality;Defect;Ensure;Environment;Evolution;Exploratory Behavior;Female;Genes;Genetic;Genetic Crossing Over;Genetic Determinism;Genetic Models;Genetic Recombination;Genetic Variation;Genome;Genomics;Gigantism;House mice;human disease;Individual;interest;Island;Laboratories;Laboratory mice;male;Meiosis;Metabolic syndrome;Methods;model organism;Mus;Mutation;Nervous System Disorder;novel;offspring;Organism;Phenotype;Population;Positioning Attribute;Process;programs;Research;Resolution;segregation;sex;System;trait;Variant;whole genome

PROJECT_TITLE: Evolution of Phenotypic Extremes and Mechanisms Governing Inheritance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: HOOVER, JOSEPH HAMILTON (contact)

PROJECT_TERMS: Address;Air;Animals;Area;Autoimmune Diseases;Autoimmunity;Biological Monitoring;Cardiovascular Diseases;chemical association;Chemical Exposure;chemical release;Chemicals;Cheyenne;Chronic Disease;cold temperature;Collaborations;Communities;community partners;Complex;contaminated water;Crow Tribe;Data;Decision Analysis;Development;Diet;Disease;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Pollution;Equity;experience;exposed human population;exposure pathway;exposure route;Exposure to;Gases;Goals;Health;health disparity;Health equity research;Health Surveys;Human;Immune;Immune response;Immunologic Markers;Immunologics;Immunology;improved;Individual;Information Dissemination;Infrastructure;Ingestion;Inhalation;innovation;Investigation;Knowledge;land use;Lead;Livestock;Malignant Neoplasms;Measurement;member;Metal exposure;Metals;Modeling;Movement;Native Americans;Navajo;novel;Oils;Outcome;outcome disparities;Participant;Pathway interactions;Patient Self-Report;Pattern;Persons;Pesticides;Pilot Projects;Plants;Plastics;Policy Maker;Population;Power Plants;predictive modeling;Process;Production;Reporting;Research;Research Project Grants;Reservations;Resources;response;Risk;Sampling;Silicones;Sioux Indians;Site;Soil;Source;Spirituality;Statistical Methods;Statistical Models;Testing;tribal community;tribal health;tribal lands;Uncertainty;Uranium;Volatilization;wasting;Water;Work;wristband

PROJECT_TITLE: Evaluating Cumulative Environmental Exposure to Metals and Non-metals and Community-level Health Using Geospatial Modeling and Personal Exposure Assessment


NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Public Health Relevance Statement Exposure to volatile organic compounds (VOCs) is an important determinant of maternal-fetal health, with implications for preterm birth and other adverse health outcomes. VOCs contaminate shallow soils and groundwater of post-industrial cities at Superfund, residential, commercial, and industrial properties, leading to exposures via vapor intrusion. The outcome of this study will help to understand the impact of VOCs on the fetal immune development and the susceptibility to respiratory viral infections in children.

PI_NAMEs: MOR, GIL G (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 2019-nCoV;Abbreviations;Address;Affect;Air Pollutants;Air Pollution;Area;Asthma;B-Lymphocytes;Benzene;Biological;Child;Chronic Disease;Cities;Clinical;Communicable Diseases;Decidua;Development;Ebola;epidemiology study;Equilibrium;ethylbenzene;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;Fetal health;fetal programming;Fetus;Future;ground water;Growth and Development function;Health;Homing;Immune;immune activation;Immune response;Immune system;implantation;in utero;Incidence;Industrialization;Infant;Infection;Inflammation;Inflammatory;Life;Link;Liver;male;Maternal Exposure;maternal morbidity;maternal outcome;microbial;Modeling;Modification;Molecular;mortality;Nature;Neonatal;neonatal morbidity;neonate;offspring;Outcome;Outcome Study;pandemic disease;pathogen;Pathogenesis;Phenotype;Placenta;postnatal;Pre-Eclampsia;preclinical study;Predisposition;Pregnancy;Pregnancy Complications;Premature Birth;prenatal exposure;prevent;Process;Property;public health relevance;Resolution;response;Severities;Signal Pathway;Signal Transduction;Site;Soil;stressor;Superfund;T cell differentiation;T-Cell Development;T-Lymphocyte;Testing;Thymocyte Development;Thymus Gland;Toluene;Training;Vaccines;vapor intrusion;Viral Respiratory Tract Infection;volatile organic compound;Volatilization;Xylene;ZIKA

PROJECT_TITLE: Impact of benzene-induced MIA on fetal T cell development

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: LUO, LI  (contact)

PROJECT_TERMS: Air Pollutants;American;Asthma;Bayesian Method;Behavior;Behavioral;behavioral economics;Biological;cancer type;causal model;Cause of Death;Chemical Exposure;Cheyenne;Chronic;Chronic Disease;cold temperature;Communities;Community Health;Complex;cost effective;Crows;Data;data management;data quality;data reuse;Data Set;Databases;Development;Diabetes Mellitus;Diet;dietary;Dimensions;Disease;Disparity;disparity reduction;Ensure;Environmental Exposure;Environmental Hazards;Environmental Health;Environmental Pollutants;Exposure disparity;exposure pathway;Exposure to;Frequencies;frontier;Future;General Population;Genetic Predisposition to Disease;Health;health determinants;Health Disparities Research;health disparity;Health equity research;high risk;Hypertension;improved;Incidence;Individual;Infectious Agent;Infrastructure;innovation;Intervention;Intervention Studies;Kidney Diseases;Knowledge;large datasets;Life Style;lifestyle factors;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;malignant stomach neoplasm;Manuscripts;Mediation;member;Metal exposure;Metals;Mining;Modeling;modifiable risk;National Cancer Institute;National Health and Nutrition Examination Survey;Native American community;Native American population;Native American Tribe;Native Americans;Navajo;Not Hispanic or Latino;novel;Nutrient;Obesity;Outcome;Pathway Analysis;Pathway interactions;Physical activity;Play;Policy Making;Population;Preparation;Prevalence;Psychosocial Stress;Public Health;Reduce health disparities;Renal Carcinoma;Reporting;Research;Research Project Grants;Resource Allocation;Resources;response;Risk;Risk Factors;Role;Sioux Indians;social;social determinants;sociodemographics;Socioeconomic Status;socioeconomics;Solid Waste Disposals;Source;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;stressor;Structure;Techniques;transmission process;tribal community;tribal lands;Uranium;War;wasting;Water

PROJECT_TITLE: Hierarchical statistical modeling and causal inference approaches to elucidate exposure pathways underlying health disparities


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: MONTROSE

ORG_NAME: HILLHURST BIOPHARMACEUTICALS, INC.

PHR: PROJECT NARRATIVE This application aims to evaluate the clinical safety, proof of concept efficacy, and pharmacokinetic profile of HBI-002, an oral low dose carbon monoxide (CO) drug product with dual mechanisms of action in a Phase 2a clinical study in sickle cell disease (SCD). If successful, this research will provide critical safety, efficacy, dosing, and mechanistic information for advancing HBI-002 into later stage clinical trials in SCD, with the ultimate objective being to provide a multimodal therapeutic to reduce the incidence of vaso-occlusive crises and inflammation, thus reducing the incidence of disability and premature mortality in this devastating disease.

PI_NAMEs: GOMPERTS, EDWARD  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adverse event;Anti-Inflammatory Agents;Binding;Biological;Biological Availability;Biological Markers;Blood flow;Blood Vessels;Canis familiaris;Carbon Monoxide;Carboxyhemoglobin;Cell Survival;Characteristics;Chronic;Circulation;Clinical;Clinical Data;clinical efficacy;Clinical Research;Clinical Trials;clinically significant;cost;Data;Development;disability;Disease;disease model;Dose;Drug Kinetics;efficacy evaluation;efficacy study;Epidemiology;Erythrocytes;experience;Family suidae;Gases;Genes;Glutamine;Goals;Hematocrit procedure;Hematology;heme oxygenase-1;Hemoglobin;Hemoglobin concentration result;Hemolysis;Human;hydroxyurea;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;inflammatory pain;Inflammatory Response;Inhalation;innovative technologies;Life Expectancy;Literature;Measures;Modality;Morbidity - disease rate;mouse model;multimodality;Mus;novel;Oral;Oral Administration;Organ;Oxidative Stress;Patient Compliance;Patients;Pharmaceutical Preparations;Phase;phase 1 study;Phase I Clinical Trials;polymerization;Polymers;pre-clinical;preclinical efficacy;preclinical study;Premature Mortality;prevent;Prevention;Process;Prodrugs;protective effect;Quality of life;Red Blood Cell Count;Reporting;Research;Research Contracts;Risk;risk/benefit ratio;Rodent;Role;Safety;safety study;Severities;Sickle Cell;Sickle Cell Anemia;sickling;standard of care;success;System;Testing;Therapeutic;Therapeutic Index;Therapeutic Uses;Toxic effect;Toxicology;Transgenic Organisms;vaso-occlusive crisis;White Blood Cell Count procedure

PROJECT_TITLE: HBI-002 to Prevent Vaso-Occlusive Crises in Sickle Cell Disease


NIH_SPENDING_CATS: Asthma;Lung

PHR: PROJECT NARRATIVE  Severe, drug-resistant asthma is a growing public health issue in the United States and worldwide, creating a large burden on the health care system. The goal of this proposed work is to understand aberrant immune responses in severe asthma, a subset of disease that is poorly responsive to standard therapies. Our novel focus on the role of immune mediators, interleukin-22 binding protein, type I interferons, and interleukin- 22, in severe asthma will identify targets for the development of new therapeutic approaches.

PI_NAMEs: MANNI, MICHELLE LYNN (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Affect;Airway Disease;airway epithelium;airway hyperresponsiveness;Allergens;allergic airway disease;Allergic Disease;Alveolar Macrophages;Animal Model;Antibodies;Antiinflammatory Effect;Asthma;asthmatic;asthmatic patient;Attenuated;Binding;Binding Proteins;Biological Availability;Biological Response Modifiers;Bone Marrow;bronchial epithelium;burden of illness;Cells;Chronic;cytokine;Data;Dendritic Cells;Development;Disease;disease model;Drug resistance;effective therapy;Epithelial Cells;Epithelium;Extrinsic asthma;Flow Cytometry;Genes;Goals;Health;Healthcare Systems;Hematopoietic;Human;IFNAR1 gene;Immune;Immune response;Immunomodulators;improved;in vivo;Incidence;Inflammation;Inflammatory;Injury;insight;Interferon alpha;Interferon Type I;Interferons;Interleukin-10;interleukin-22;Interleukins;Investigation;Ligands;Link;Lung;Lymphoid Cell;Modeling;Molecular;Mucous body substance;mucus hypersecretion;Mus;Myelogenous;new therapeutic target;novel;novel therapeutic intervention;Ovalbumin;overexpression;Pathogenesis;Pathway interactions;personalized medicine;Persons;Play;pre-clinical;protein expression;Public Health;Publishing;Pulmonary Inflammation;Pyroglyphidae;receptor;Refractory Disease;repaired;Reporter;response;Role;Sampling;Serum;Severity of illness;Signal Transduction;Source;Sputum;STAT1 gene;STAT2 gene;STAT3 gene;Steroid Resistance;Steroids;Subgroup;Surface;targeted treatment;Testing;Th2 Cells;Tissues;United States;Wild Type Mouse;Work

PROJECT_TITLE: Immune Mediators of IL-22 Signaling Alter Allergic Airway Disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Reproductive success in several mammalian species is greatly limited by embryo loss due to chromosomal abnormalities, or aneuploidy. The proposed studies aim to determine the precise relationship between aneuploidy and a dynamic process called cellular fragmentation that differs in frequency across mammals using a comparative genomics approach. This work has the potential to improve reproductive efficiency in agriculturally important animals and for translational application to human assisted reproduction.

PI_NAMEs: CARBONE, LUCIA ;CHAVEZ, SHAWN L. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Agriculture;Aneuploid Cells;Aneuploidy;aneuploidy analysis;Animals;Appearance;assisted reproduction;blastocyst;Cattle;Cell division;Cell Physiology;Cells;Chromosomal Gain;Chromosomal Loss;Chromosome abnormality;chromosome missegregation;Chromosome Segregation;Chromosomes;comparative;comparative genomics;Comparative Study;Copy Number Polymorphism;Cytokinesis;Cytoplasm;Cytoskeleton;Data;Detection;Development;differential expression;DNA;DNA Fragmentation;DNA sequencing;Embryo;Embryo Loss;embryo stage 2;Embryonic Development;Encapsulated;Equus caballus;Exhibits;failure Implantation;Family suidae;Female;Fertility;Fertilization in Vitro;Frequencies;Gene Expression;Genes;genetic manipulation;genome analysis;Genomic approach;Goals;Human;Image;Implant;implantation;improved;In Vitro;in vivo;Incidence;insight;Investigation;knock-down;Link;live cell imaging;Macaca mulatta;Mammals;Maternal Age;Measures;Meiosis;Messenger RNA;Methods;Microinjections;micronucleus;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Molecular;Monitor;mosaic;Mus;natural Blastocyst Implantation;nonhuman primate;offspring;overexpression;Pathway interactions;Ploidies;Pre-implantation Embryo Development;Pregnancy;Prevalence;Primates;Process;real-time images;reproductive;reproductive success;Resolution;Rhesus;RNA Decay;Role;species difference;Spontaneous abortion;success;Testing;Tissue-Specific Gene Expression;transcriptome sequencing;translational applications;Trees;whole genome;Work

PROJECT_TITLE: Comparative Analysis of Aneuploidy and Cellular Fragmentation Dynamics in Mammalian Embryos

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eczema / Atopic Dermatitis;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Atopic Dermatitis remains one of the most important challenges to pediatric public health in the United States affecting millions of children and adults, and continues to increase in prevalence, causing significant morbidity, mortality, and tremendous financial burden. The causes, genetic bases and relationship between S aureus skin colonization and AD remain incompletely understood. We will contribute extensively to the Atopic Dermatitis Research Network as a Clinical Research Unit through successful implementation, scientific expertise, and training of the next generation of NIH funded investigators skilled in AD. We will also specifically examine the role of genetic and microbial modifiers in AD by investigating the mechanisms of increased AD severity in patients with the R576 polymorphism in IL-4Rα and the impact of S aureus skin decolonization on AD

PI_NAMEs: GEHA, RAIF SALIM (contact);PHIPATANAKUL, WANDA

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Academic Medical Centers;Adult;Affect;Allergic;Allergic Disease;Antigens;Arginine;Atopic Dermatitis;base;Biological;Biological Markers;Biology;Biometry;Blood;Bone Marrow;Boston;Cells;Child;Childhood;Chimera organism;Clinic;Clinical;clinical center;clinical diagnosis;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Cutaneous;Data;data management;Dermatology;Development;Disease;Disease Marker;experience;Financial Hardship;fundamental research;Funding;Gene Expression;General Hospitals;Generations;Genetic;Genetic Polymorphism;Genotype;Glutamine;Hematopoietic;Hospitals;Human;Human Resources;Hypersensitivity;Immune;Immunologics;Immunology;improved;Inflammation;Infrastructure;injured;Institutional Review Boards;Interleukin-13;Interleukin-4;Knowledge;Laboratories;laboratory facility;Laboratory Research;Link;Massachusetts;Mechanics;member;microbial;Microbiology;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;National Institute of Allergy and Infectious Disease;next generation;novel;Observational Study;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Pharmaceutical Services;Population;Prevalence;Protocols documentation;Public Health;Quality Control;receptor;Records;recruit;repository;Research;research facility;Research Personnel;response;Role;Sampling;Schools;Seasons;Severities;Severity of illness;Shipping;Signal Transduction;Site;skills;Skin;skin barrier;Skin colonization;Staphylococcus aureus;statistics;Testing;Topical application;Training;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Genetic and microbial modifiers of Atopic Dermatitis (AD): Mechanisms of increased AD severity in patients with the R576 polymorphism in IL-4Ra and impact of S aureus skin decolonization on AD


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Nutrition

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Macrophages play a critical role in host defense and tissue repair, but their dysregulation leads to chronic inflammatory diseases associated with metabolic disorders. Our data support a new paradigm that implicates Mao A and Nox4-derived ROS production in both monocyte “priming” and dysfunction induced by metabolic disorders and the subsequent reprogramming of monocyte-derived macrophages as early and essential drivers of atherogenesis. The studies we propose here aim to test this novel paradigm and to elucidate the underlying molecular mechanisms.

PI_NAMEs: ASMIS, RETO H.R. (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Adhesions;atherogenesis;Atherosclerosis;Autophagocytosis;biological adaptation to stress;Bone Marrow;Calories;Cardiovascular Diseases;catalase;Cell Death Induction;Chemotactic Factors;ChIP-seq;Chronic;chronic inflammatory disease;Data;Development;Diet;feeding;Functional disorder;Genes;Glutathione;Grx1 protein;Hematopoietic;Homeostasis;Host Defense;Human;human subject;Hydrogen Peroxide;Impairment;Inflammation;Inflammatory;knock-down;Link;Macrophage;Mediating;Mediator;Memory;Metabolic;Metabolic Diseases;Metabolism;migration;Mitogen-Activated Protein Kinases;Molecular;molecular modeling;Monoamine Oxidase A;monocyte;Mus;Myelogenous;NADPH Oxidase;novel;novel therapeutics;Nutrient;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Peritoneal Macrophages;Phenotype;phosphatase-1 kinase;Play;preservation;prevent;Prevention;Production;Proteins;Proteomics;Reactive Oxygen Species;Reporting;response;Role;Severities;Source;Stress;Sulfhydryl Compounds;Testing;tissue repair;Tissues;transcriptome sequencing;Transferase

PROJECT_TITLE: Role of Monoamine Oxidase A and Diet-Induced Monocyte Dysfunction, Macrophage Reprogramming, and Atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE (RELEVANCE) T helper 17 (Th17) cells are critical to immunity at mucosal surfaces such as the intestine, however, these pro- inflammatory cells have also been implicated as mediators of autoimmunity in conditions such as Inflammatory Bowel Disease (IBD), Multiple Sclerosis, Rheumatoid Arthritis, and Psoriasis. Recent work has highlighted the ability of Th17 cells to convert into other CD4 T cell subtypes, including anti-inflammatory regulatory T cells, providing a strategy for therapeutic intervention. This project investigates the mechanisms that control the stability of Th17 cell identity that can be exploited in autoimmune disease to extinguish damaging inflammatory responses.

PI_NAMEs: CIOFANI, MARIA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Adopted;Adoption;Anti-Inflammatory Agents;Applied Genetics;Architecture;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;Automobile Driving;Bacteria;Biological Assay;candidate validation;CD4 Positive T Lymphocytes;Cell Lineage;Cell Physiology;cell type;Cells;Characteristics;Chromatin;Chromatin Loop;CRISPR/Cas technology;cytokine;Disease;Effector Cell;effector T cell;Elements;Environment;epigenomic profiling;epigenomics;Exhibits;Experimental Autoimmune Encephalomyelitis;flexibility;Funding;fungus;Gene Expression Regulation;Gene Targeting;Genetic Transcription;Genome;Genomics;Helper-Inducer T-Lymphocyte;IL17 gene;Immune response;Immunity;in vivo;Infection;Infiltration;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Intestines;Knowledge;Maps;Mediator;Molecular;Molecular Conformation;mouse model;Mucosal Immunity;Mucous Membrane;Multiple Sclerosis;novel;Pathogenicity;Pathology;Play;preservation;programs;Proteins;Psoriasis;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Reporter;Reporting;Rheumatoid Arthritis;Role;Series;single cell ATAC-seq;Site;Spinal Cord;Structure;Surface;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic Intervention;tool;trait;transcription factor;Work

PROJECT_TITLE: Regulatory mechanisms governing Th17 cell effector identity and plasticity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Orthopoxviruses;Rare Diseases

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative Poxviruses are infectious agents that are causing growing number of infections and have well-acknowledged bioterror potential. Through the work described here we will develop a class of small molecules that block the ability of critical poxvirus machinery to function. We will define how the molecule works and create a high-potency analog that will act as a therapeutic approach to broadly combat poxviral disease.

PI_NAMEs: CONNOR, JOHN H (contact);SCHAUS, SCOTT EDWARD

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Adenoviruses;analog;Animal Model;Anti-viral Agents;antimicrobial;Behavior;beta-Lactams;Biochemical;Biological Assay;Biology;Bioterrorism;Cameroon;candidate selection;Category A pathogen;Cells;Central African Republic;Characteristics;Chemicals;Circulation;Collaborations;combat;comparative;Complement;Cowpox;Data;Democratic Republic of the Congo;Development;Disease;Disease Outbreaks;DNA;DNA-Directed RNA Polymerase;Dose;Drug Kinetics;Drug Targeting;druggable target;efficacy evaluation;efficacy testing;Enzymes;experimental study;Family;first-in-human;General Population;Genetic;Goals;Hepatitis C virus;Herpesviridae;human pathogen;Immunity;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Infection;Infectious Agent;inhibitor;interest;Investigational Drugs;Israel;Licensure;Mail Order;Messenger RNA;Modality;Modification;Molecular Target;Monkeypox;Morbidity - disease rate;mortality;Nigeria;novel;Orf virus;Orthopoxvirus;pathogen;pathogenic bacteria;pathogenic fungus;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Polymerase;Population;Poxviridae;Poxviridae Infections;pre-clinical assessment;Production;Property;Protease Inhibitor;reconstitution;Regimen;Reporting;Resistance;Risk;RNA Polymerase I;RNA Viruses;Safety;scaffold;Sierra Leone;Singapore;small molecule;small molecule therapeutics;Smallpox;Testing;Therapeutic;therapeutic development;Toxic effect;Travel;United States Food and Drug Administration;Vaccines;Vaccinia;Variola major virus;Viral;Viral Physiology;viral resistance;Virus;Virus Replication;Work;World Health

PROJECT_TITLE: Advancement of poxvirus inhibitor

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Contraception/Reproduction;Maternal Health;Nanotechnology;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

PHR: Each year, more than $26 billion is spent on treatment and care of babies born prematurely, not accounting for the lifelong impact of developmental and cognitive impairments. Only one approved product is available for prevention of preterm birth in limited cases, so there is significant room for innovation. Herein, we propose studies that build from exciting preliminary data using nanomedicine to address fundamental questions regarding route of administration, pharmacokinetics, as well as validating drugs that could be reformulated and repurposed for more effective prevention of PTB.

PI_NAMEs: BURD, IRINA ;ENSIGN, LAURA  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 37 weeks gestation;absorption;Address;autism spectrum disorder;Birth;Birth Rate;Brain;Brain Injuries;Caproates;Cells;Cerebral Palsy;Cervix Uteri;Clinical Trials;Cognitive;Complex;Cream;Data;delayed birth;design;Development;Dose;drug action;drug candidate;Drug Combinations;Drug Delivery Systems;Drug Kinetics;drug market;Drug Targeting;Drug Transport;effective therapy;Excipients;Exposure to;female reproductive tract;fetal;fetal inflammatory response syndrome;Formulation;Gene Expression;Gene Expression Profiling;healthy pregnancy;Histone Deacetylase Inhibitor;Human;Hydroxyprogesterone;Immune;Immune response;Immune system;Immunologics;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;indexing;Infant Care;Infant Mortality;Infiltration;Inflammation;Inflammatory Response Pathway;Injections;innovation;intrauterine inflammation;Label;Live Birth;maternal risk;Measures;Membrane;Methods;Modeling;mouse model;Mucous Membrane;Mus;Myometrial;myometrium;nano;nanoformulation;nanomedicine;Neonatal;neurobehavioral;Neuroimmune;novel;Outcome;Penetration;Perinatal Brain Injury;Pharmaceutical Preparations;Pharmacotherapy;Placenta;preclinical study;Pregnancy;premature;Premature Birth;Premature Labor;prenatal exposure;prevent;Prevention;Prevention approach;Progesterone;pup;receptor expression;Receptor Gene;Recording of previous events;reproductive;reproductive tract;Route;Schizophrenia;side effect;Supplementation;Suspensions;Synthetic Progestogens;targeted treatment;Therapeutic;Therapeutic Effect;Tissues;Tocolytic Agents;Toxic effect;treatment effect;Trichostatin A;Uterine Contraction;Uterus;Vagina;Vaginal delivery procedure;Validation;Withdrawal;Woman;zeta potential

PROJECT_TITLE: Nanomedicine approaches for prevention of inflammation-induced preterm birth


ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Striated muscle myosin molecules are highly organized within exquisite force generating macromolecular complexes, but myosin molecules must somehow be replaced while continually supporting muscle contractility. Our preliminary data demonstrate that the organization of myosin is highly dynamic and rearranges on a minute-to-minute timescale in intact muscle. This project will establish the mechanisms that regulate the dynamic rearrangement of myosin in muscle and provide insight into how we can tune these mechanisms to alter muscle structure.

PI_NAMEs: PREVIS, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Adult;Affect;Amino Acids;Animal Model;Animals;Biochemical;Biological Assay;Biophysical Process;Biophysics;Cardiac;Cardiac Myosins;confocal imaging;Cytoplasm;Cytosol;Data;Data Analyses;design;Electron Microscopy;Equilibrium;Exhibits;Filament;Fluorescence Recovery After Photobleaching;Half-Life;Heart;Human;in vivo;Individual;inhibitor;innovation;insight;Isotope Labeling;Knowledge;Label;Macromolecular Complexes;Mass Spectrum Analysis;microscopic imaging;Modeling;Molecular;Molecular Conformation;monomer;mouse model;multi-photon;Mus;Muscle;muscle form;Muscle function;muscular structure;muscular system;Myocardium;Myosin ATPase;Nature;novel;novel therapeutics;Organ;Pathology;Pharmaceutical Preparations;Polymers;prevent;Property;protein expression;Proteins;reduced muscle mass;Resolution;Sarcomeres;single molecule;small molecule;Stable Isotope Labeling;Stochastic Processes;Striated Muscles;Structure;Testing;Thick Filament;Viral;Viral Proteins

PROJECT_TITLE: Mechanisms governing myosin turnover and exchange in vivo.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Depression;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Pain Research;Palliative Care;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative (Relevance) Family surrogates of critically ill patients experience severe psychological distress that undermines their capacity to make end-of-life decisions congruent with patient values, further exacerbating their risk of prolonged grief, psychological trauma, and regrets. A cycle of emotional pain ensues. Responding to the urgent need for effective, culturally sensitive, and widely accessible interventions for these vulnerable patients and their families, EMPOWER holds great promise for breaking this cycle of emotional pain and promoting family surrogates' psychological adjustment, thereby enhancing their decisional capacity, promoting patients' receipt of values-concordant end- of-life care, and psychological adjustment in bereavement.

PI_NAMEs: LICHTENTHAL, WENDY G.;PRIGERSON, HOLLY GWEN (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Advance Care Planning;Affect;Anger;Behavioral;Bereavement;Black race;Black, Indigenous, People of Color;Breathing;Caregivers;Caring;Cessation of life;Cognitive;Communication;comparative efficacy;Confusion;Conscious;contextual factors;coronavirus pandemic;COVID-19;COVID-19 pandemic;COVID-19 patient;Critical Illness;cultural competence;Data;Decision Making;Disabling;Disease;disease transmission;Disorientation;Dissemination and Implementation;Distress;efficacy evaluation;Emotional;end of life;end of life care;Equipment and supply inventories;experience;Family;Family Caregiver;Family health status;Family member;Feeling;flexibility;future implementation;Goals;Grief reaction;Guilt;Hospitals;improved;Indigenous;insight;Intensive Care Units;Intervention;intervention effect;Interview;Left;Life;Life Experience;Loneliness;loved ones;Mediating;Mediation;Mediator;Medical;Medical center;meetings;Memorial Sloan-Kettering Cancer Center;Mental Depression;Mental Health;Methods;Modeling;Numbness;Outcome;Pain;Palliative Care;pandemic disease;pandemic disruption;Parents;Patients;people of color;perceived discrimination;Persons;Positioning Attribute;post intervention;post-traumatic stress;Post-Traumatic Stress Disorders;Presbyterian Church;primary outcome;psychologic;Psychological adjustment;psychological distress;psychological outcomes;Psychological Techniques;psychological trauma;psychosocial;Quality of Care;Race;racial disparity;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Regrets;Reporting;resilience;Risk;Role;secondary outcome;Severities;Site;Social Distance;Standardization;stress symptom;Structure;symptomatic improvement;Symptoms;Techniques;telehealth;Thinking;Trauma;traumatic stress;treatment as usual;United States;United States National Institutes of Health;Videoconferencing

PROJECT_TITLE: A Multisite Randomized Controlled Trial of EMPOWER for Family Surrogates of Critically Ill Patients

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]