PI_NAMEs: MATZINGER, POLLY C (contact)

PROJECT_TERMS: Adult;Area;Autoimmune Responses;Autoimmunity;Cells;Chicago;Collaborations;Communication;Development;Education;fighting;Genes;healing;Health;humoral immunity deficiency;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunologist;immunoreaction;infancy;Infection;intestinal epithelium;Intestines;Malignant Neoplasms;Modeling;Mus;National Institute of Allergy and Infectious Disease;Natural regeneration;Neonatal;neonate;Organism;Parasitology;pathogen;Research;response;Scientist;Signal Transduction;System;T-Lymphocyte;Testing;Thymus Gland;Tissues;Transplantation;Universities;Vaccines;Virus Diseases

PROJECT_TITLE: The Danger Model 2: how tissues control Immunity


ACTIVITY: ZIA

ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hematology;Hepatitis;Hepatitis - C;Human Genome;Infectious Diseases;Liver Cancer;Liver Disease;Lung;Lymphatic Research;Lymphoma;Pancreatic Cancer;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: LETO, THOMAS  (contact)

PROJECT_TERMS: Acute;Affect;Agammaglobulinaemia tyrosine kinase;Agonist;Anabolism;Animal Model;Anti-Inflammatory Agents;Anti-viral Response;antifibrotic treatment;antimicrobial;Apoptosis;Area;B lymphoid malignancy;Biochemical;Biological Assay;Brain Neoplasms;Breast;Cancer Patient;candidate identification;Cell Aging;Cell Culture Techniques;Cell model;cell motility;Cell Survival;Cells;chemokine;Chronic Granulomatous Disease;Chronic Hepatitis C;chronic inflammatory disease;Cirrhosis;Colon;cytokine;Defect;Disease;Disease Progression;DNA Sequence Alteration;Dose;Enzymes;Epithelial Cell Proliferation;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exhibits;Extracellular Matrix;Family;Fibrosis;Follow-Up Studies;Gastrointestinal tract structure;gene expression database;Genes;Genetic Polymorphism;Growth Factor;Hematopoietic;Hepatic;Hepatitis C;Hepatocyte;HepG2;Homologous Gene;Hormones;Host Defense;Hot Spot;Human;Hypoxia;Immune;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;insight;interest;Isoenzymes;Kidney;KPC model;KRAS2 gene;Liver;Lung;Lymphoid Cell;Macrophage;Malignant Neoplasms;Matrix Metalloproteinases;Mediating;Metastatic Carcinoma;microbial;microbicide;MMP2 gene;MMP9 gene;Molecular;mouse model;Mucous Membrane;Mus;mutant;Mutation;Mycoses;Myeloid Cells;NADPH Oxidase;National Center for Advancing Translational Sciences;Natural Immunity;Neoplasm Metastasis;neoplastic cell;neutrophil;neutrophil cytosol factor 40K;Normal tissue morphology;novel;Nox enzyme;overexpression;Oxidases;Oxidation-Reduction;Oxidative Stress;Pancreas;Pancreatic Ductal Adenocarcinoma;pathogen;patient population;Patients;Pattern;Pattern Recognition;Peroxidases;peroxiredoxin;Phagocytes;Pharmacodynamics;pharmacologic;Phenotype;Phospholipase A2;Phosphorylation;Population;Predisposition;prevent;Primary carcinoma of the liver cells;Primary Neoplasm;Process;Production;programs;Proliferating;protective effect;Reactive Oxygen Species;receptor;Recombinants;reconstitution;recruit;Research;Respiratory System;Respiratory Tract Infections;response;Role;screening;senescence;Signal Transduction;Specificity;Surface;Surveys;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;TP53 gene;transcriptomics;Transforming Growth Factor beta;translational goal;Traumatic Brain Injury;tumor;Tumor Cell Migration;tumor microenvironment;tumor progression;Work;wound closure;wound healing

PROJECT_TITLE: NOX family NADPH oxidases: roles in innate immunity and inflammatory disease


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: MURPHY, PHILIP  (contact)

PROJECT_TERMS: 6 year old;Adult;Age;Alveolar Bone Loss;AMD3100;antagonist;Area;Biological;Blood;Bone Marrow;Bone Pain;boys;Caring;Cell surface;Cells;Cellular biology;chemokine receptor;Chemotactic Factors;Clinical;clinical phenotype;cohort;congenital immunodeficiency;Cross-Over Trials;CXCR4 gene;Diagnosis;Disease;disease model;early onset;Epidemiology;Evaluation;Exanthema;Failure;Family;fMet-Leu-Phe receptor;gain of function;Gender;Gene Family;Genes;Genetic;Genetic Polymorphism;Genomics;Goals;granulocyte;healthy volunteer;Hematology;Herpesviridae;Heterogeneity;Heterozygote;HIV;Human;human disease;Immunologic Deficiency Syndromes;improved;Incidence;Individual;Infection;Journals;knockout gene;Knockout Mice;Knowledge;leukocyte activation;Leukocytes;Ligature;Lymphocyte Count;Lymphopenia;Masks;Mediating;Medical;member;Methods;migration;Molecular;Molecular Analysis;Molecular Biology;mouse model;Mus;Mutation;Neutropenia;neutrophil;new therapeutic target;novel;Oral;Pathogenesis;Patients;Periodontitis;Pharmaceutical Preparations;Phase;Phenotype;Poxviridae;Predisposition;preference;primary endpoint;Process;Property;Proteins;Quality of life;Randomized;receptor;Receptor Gene;Reporting;Research;Research Personnel;Risk Factors;Role;Safety;Serious Adverse Event;Severe congenital neutropenia;Severities;Signal Transduction;Site;standard of care;Structure;System;Testing;Tissues;Translating;trial comparing;Virus;WHIM syndrome

PROJECT_TITLE: Molecular Analysis Of Leukocyte Activation By Chemoattractants


PI_NAMEs: MARGULIES, DAVID  (contact)

PROJECT_TERMS: Adaptive Immune System;Affinity;Alleles;Antigen Presentation;Antigen Presentation Pathway;base;Binding;Binding Proteins;Cell Surface Receptors;Complex;Cross Presentation;Cryoelectron Microscopy;diagnostic development;Event;flexibility;Goals;HLA-B Antigens;Immune;Immune system;Immunologic Receptors;Innate Immune System;knockout animal;Knockout Mice;Knowledge;Laboratories;Ligands;Lymphoid Cell;macromolecule;Methods;Molecular;Molecular Chaperones;Molecular Conformation;molecular recognition;Molecular Structure;Pathway interactions;Peptides;Play;Process;receptor;Receptor Cell;Reporting;Roentgen Rays;Role;Signal Transduction;Structure;System;tapasin;Therapeutic;tool;Tumor Antigens;Viral Antigens;X-Ray Crystallography

PROJECT_TITLE: Molecular Interactions Of Lymphoid Cell Receptors


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Infant Mortality;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: MALECH, HARRY L (contact)

PROJECT_TERMS: Acute Graft Versus Host Disease;adeno-associated viral vector;adenosine deaminase deficiency;Affect;Alkylating Agents;Allogenic;Animal Model;Antibodies;Antibody-drug conjugates;Artemis deficiency;Autoimmunity;autoinflammation;Autologous;base editing;Biological Products;Blood;CD34 gene;Cell Line;Cell model;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor T cells;chronic graft versus host disease;Chronic Granulomatous Disease;Clinic;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;conditioning;congenital immunodeficiency;Defect;design;Development;Disease;Dose;Elements;Engineering;Engraftment;Epidemiology;Failure;Functional disorder;gain of function;gene therapy;gene therapy clinical trial;gene transfer vector;gene-editing approach;Genes;Genetic;Goals;graft vs host disease;Hematological Disease;Hematopoiesis;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Research;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;Human;Hypersensitivity;Immune;immune function;Immune System Diseases;Immunity;Immunoglobulin M;Immunologic Deficiency Syndromes;Impairment;improved;induced pluripotent stem cell;Infection;Infection Control;infection management;infection risk;Inflammation;Inflammatory Bowel Diseases;Inherited;Institution;Laboratories;Lentivirus Vector;Link;Marrow;Mediating;Medical;member;Messenger RNA;Methods;mouse model;Mutation;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;Natural History;Neutropenia;novel;novel strategies;Omenn syndrome;Other Genetics;Outcome;Oxidases;Patients;Pharmaceutical Preparations;Physiology;pre-clinical;preclinical development;prevent;Prevention;primary immune regulatory disorders;prime editing;programs;Publications;Reagent;Recovery;Regimen;Reporting;Research;Research Personnel;Safety;Severe Combined Immunodeficiency;Small Interfering RNA;Source;STAT1 gene;stem cell engraftment;stem cell gene therapy;Syndrome;Testing;Therapeutic;Therapeutic Clinical Trial;Therapy Clinical Trials;tool;Transfection;Translations;Transplantation;transplantation therapy;United States National Institutes of Health;vector;WHIM syndrome;Wiskott-Aldrich Syndrome;Work;x-linked Hyper-IgM Syndrome;Xenograft procedure

PROJECT_TITLE: Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine

PI_NAMEs: DE RAVIN, SUK SEE  (contact)

PROJECT_TERMS: Address;aged;Antibodies;Autoimmune;Autologous;base editing;Blood Cells;CD34 gene;Cell Survival;Cell Therapy;Cells;cellular transduction;Chronic Granulomatous Disease;Clinical;clinical application;Clinical Trials;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;comparative efficacy;conditioning;congenital immunodeficiency;CRISPR/Cas technology;CTLA4 gene;CXCR4 gene;Data;Dependovirus;design;Development;Disease;DNA Damage;DNA Double Strand Break;DNA Sequence;Engineering;Enhancers;Enzymes;experience;Exposure to;gene correction;Gene Expression Regulation;gene therapy;gene therapy clinical trial;Genes;Genetic;genome editing;Genomic Instability;genotoxicity;Goals;granulocyte;Guide RNA;Hematopoietic stem cells;HMGA2 gene;IL2RG gene;immune reconstitution;Immunity;immunodeficiency;improved;in vivo;Individual;Infusion procedures;Institutional Review Boards;Laboratories;Link;Longterm Follow-up;manufacture;Mediating;Messenger RNA;Mission;Modification;Molecular;Mutation;mutation correction;Myelogenous;National Institute of Allergy and Infectious Disease;novel therapeutics;nuclease;older patient;Oligonucleotides;Outcome;Patients;Phase;Phase I/II Clinical Trial;pre-clinical;preclinical study;Preparation;prime editing;Procedures;programs;Prostaglandins;Recording of previous events;Regimen;repaired;response;RNA Splicing;Safety;safety study;Severe Combined Immunodeficiency;Site;Specificity;stem cell genes;stem cells;tool;Transcript;transduction efficiency;Transfection;Translating;Translations;tumorigenesis;Variant;vector;Virus;X-Linked Severe Combined Immunodeficiency

PROJECT_TITLE: Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: STREBEL, KLAUS  (contact)

PROJECT_TERMS: Actin-Binding Protein;Actins;Adopted;Affect;Affinity;Affinity Chromatography;Aneuploidy;Anti-viral Therapy;Automobile Driving;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Blood;C-terminal;CD4 Positive T Lymphocytes;Cell Lineage;Cells;Centrioles;Centrosome;Co-Immunoprecipitations;Code;Collaborations;Complex;CSF1 gene;Dendritic Cells;Development;Elements;Endothelial Cells;env Genes;Environment;Equilibrium;Event;Exhibits;experimental study;Feedback;Fellowship;GAG Gene;Gel;Gelsolin;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Health;HIV;HIV-1;HIV-2;Human;Individual;Infection;insight;Integration Host Factors;interest;Link;Liver;Lymphatic;Macrophage;Malignant Neoplasms;mannose receptor;Molecular;Molecular Analysis;Molecular Conformation;monocyte;Mutation;Myelogenous;novel;particle;Pathway interactions;Persons;PLK1 gene;pol genes;Portugal;posttranscriptional;Primate Lentiviruses;Procentriole;Process;Proliferating;promoter;Property;Proteins;proto-oncogene protein Spi-1;Publishing;receptor;Receptor Gene;receptor-mediated signaling;Reporting;Research;Risk;Role;Surface;T-Cell Lymphoma;Tissues;transcription factor;transmission process;tumorigenesis;ubiquitin-protein ligase;V3 Loop;vif Gene Products;Viral;Viral Genes;Viral Physiology;Virion;Virus;virus host interaction;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Molecular Analysis Of Retroviral Genes And Their Products


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Natural Products;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: BARRY, CLIFTON  (contact)

PROJECT_TERMS: absorption;Adverse event;Anabolism;Antibiotic Therapy;Area;ATP phosphohydrolase;Bacteria;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Biology;Cell Wall;chemical synthesis;Chemicals;Coculture Techniques;cofactor;Collaborations;Collection;crosslink;Cryoelectron Microscopy;cytotoxic;Data;Development;DNA Resequencing;Dose;Drops;drug development;efficacy study;Enzymes;Equilibrium;Exclusion;Excretory function;follow-up;Frequencies;functional genomics;fungus;Gene Cluster;Genes;Genome;genome sequencing;Genus Mycobacterium;Granuloma;Growth;high throughput screening;Human;Human Microbiome;Hypoxia;improved;in vivo;inhibitor;interest;Kinetics;Label;Lead;lead optimization;lead series;Libraries;Ligands;Maps;Medical Research;member;Metabolism;metabolomics;microbial;Microsomes;Mutation;mycobacterial;Mycobacterium tuberculosis;nanomolar;Natural Products;Natural Source;new chemical entity;novel;Nutrient;Organism;Oxazolidinones;oxidation;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peat;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;pharmacophore;Phase I Clinical Trials;Phenotype;Physiological;Physiology;Positioning Attribute;pre-clinical;Probability;Process;Prodrugs;Production;Property;protein complex;Proteins;Recombinants;research clinical testing;Research Institute;Resistance;resistance frequency;resistance mutation;Respiration;respiratory;response;Ribosomes;scaffold;screening;secondary metabolite;Series;Site;small molecule libraries;Solubility;Sphagnum Moss;Stress;Sulfhydryl Compounds;Superhelical DNA;Testing;Therapeutic;Thermodynamics;Titrations;transcriptome sequencing;Traumeel S;Tuberculosis;tuberculosis chemotherapy;tuberculosis treatment;uptake;whole genome;Work;Xenobiotics

PROJECT_TITLE: Development Of New Chemotherapeutics For Tuberculosis


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: MARQUES, ADRIANA R (contact)

PROJECT_TERMS: Address;Annual Reports;Antibiotic Therapy;Antibiotics;Area;Arthralgia;biobank;Biological Markers;Borrelia burgdorferi;Borrelia Infections;Case Study;clinical database;Clinical Protocols;Clinical Research;Country;Development;erythema migrans;Europe;European;Fatigue;Frequencies;Headache;Health;Heart;Human;Immune response;Immunity;Individual;Infection;Investigation;Joints;Lyme Disease;Lyme disease diagnosis;Memory;Myalgia;Names;Neck;Nervous System;Order Spirochaetales;Outcome;Paresthesia;Patients;Post Treatment Lyme Disease Syndrome;recruit;Research;Role;Skin;sleep difficulty;Sleep Disorders;Symptoms;Syndrome;System;Testing;Tick-Borne Diseases;Ticks;treatment response;Work

PROJECT_TITLE: Assessment Of Patients With Borrelia Infection


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: SUN, PETER D. (contact)

PROJECT_TERMS: Adoptive Transfer;Alloantigen;Allogenic;Amino Acids;Animal Model;Animals;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Binding;Biological Models;CD8-Positive T-Lymphocytes;CD94 Antigen;Cell Communication;Cell Physiology;Cells;Charge;Chemotherapy and/or radiation;Clinical;Clonal Deletion;Collaborations;comparative;Competence;complementarity-determining region 3;Cysteine;Donor person;Exhibits;Frequencies;Genotype;Germ Lines;Goals;graft vs host disease;HLA-C Antigens;Hydrophobicity;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;Individual;insight;interest;KRAS2 gene;Length;Malignant Neoplasms;Melanoma;Mixed Lymphocyte Culture Test;Molecular;Mus;Mutate;Mutation;neoantigens;Peptides;Proliferating;Property;Proteins;receptor;Receptor Cell;Role;Sequence Analysis;Spleen;stem;T cell therapy;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Therapeutic;Thymus Gland;Time;tool;Transplantation;Treatment Efficacy;tumor;Tumor-Infiltrating Lymphocytes;V(D)J Recombination;Viral;Work

PROJECT_TITLE: Structural and functional characterization of T and NK cell receptors


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

PI_NAMEs: KRISTIE, THOMAS M (contact)

PROJECT_TERMS: Address;Afferent Neurons;Animal Model;Biochemical;Biological Models;Cell Communication;Cell Culture System;Cell Culture Techniques;Chromatin;chromatin modification;Complex;Data;design;Disease;DNA Binding;Early Gene Transcriptions;Enhancers;Enzymes;Epigenetic Process;Eye diseases;Gene Expression;Genes;Genetic Transcription;Genitalia;Goals;host cell factor C1;Immediate-Early Genes;in vivo;Individual;inhibitor;insight;latent infection;Lesion;Life Cycle Stages;Lytic;Lytic Phase;Mediating;Multiprotein Complexes;Neurons;nucleocytoplasmic transport;Oral;Play;Primary Cell Cultures;Primary Infection;Productivity;protein complex;Proteins;reactivation from latency;Recurrence;Role;Signal Transduction;Simplexvirus;Stimulus;Transcription Coactivator;Transcriptional Elongation Factors;Transcriptional Regulation;Viral;Viral Genes;Viral Genome;Virus;Virus Assembly;Virus Latency

PROJECT_TITLE: Transcriptional control of herpes simplex virus lytic infection and latency-reactivation cycles


PI_NAMEs: MCBRIDE, ALISON  (contact)

PROJECT_TERMS: Architecture;Autonomous Replication;Cell Differentiation process;Cell division;Cell Line;Cell Nucleus;Cells;chromosome conformation capture;Chromosomes;daughter cell;design;Development;DNA;DNA amplification;DNA biosynthesis;Elements;Epithelium;Genome;Host Defense;Human papilloma virus infection;Human Papillomavirus;In Situ;Life Cycle Stages;Maintenance;Malignant Neoplasms;Microscopy;Molecular;Papillomavirus;Phase;Resolution;Stratified Epithelium;Surface;Therapeutic;Time;viral DNA;Virus;Virus Diseases;Virus Replication;Visualization

PROJECT_TITLE: Replication mechanisms of human papillomaviruses (HPV)


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pediatric;Precision Medicine;Prevention

PI_NAMEs: SU, HELEN  (contact)

PROJECT_TERMS: 12 year old;4 year old;Affect;Age;Age of Onset;Animal Model;Antigen Targeting;antigen-specific T cells;Antigens;Apoptosis;apoptosis in lymphocytes;Attention;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Autopsy;biobank;Biological;Blinded;British Columbia;Canada;Categories;causal variant;Cell Death Induction;Cells;Central Nervous System;Cerebrospinal Fluid;Cessation of life;Clinical Treatment;cohort;Colitis;Collaborations;Correlation Studies;Demyelinating Diseases;Demyelinations;Diagnosis;disability;Disease;Disease Outcome;Distant;DNA;exome sequencing;Family;Family member;FDA approved;fitness;follow-up;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;genetic variant;genome wide association study;Genomics;Goals;Immune;Immune System Diseases;Immunity;immunodeficiency;Immunologics;indexing;individualized medicine;Inflammatory;Inherited;inhibitor;International;Investigation;Knowledge;Lesion;lymphadenopathy;man;member;Molecular;molecular targeted therapies;Multiple Sclerosis;multiple sclerosis patient;Mutation;Myelin Proteins;National Institute of Neurological Disorders and Stroke;next generation sequencing;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phase;Phase I Clinical Trials;PIK3CG gene;Population;precision medicine;Predisposition;prevent;Process;programs;Progressive Disease;Proteins;randomized placebo controlled study;Recombinants;Regulation;Relapsing-Remitting Multiple Sclerosis;Research;Research Personnel;Retrospective Studies;Role;Sampling;senescence;Single Nucleotide Polymorphism;small molecule;Specificity;Spinal Cord;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;therapeutically effective;Time;Twin Studies;Universities;Variant

PROJECT_TITLE: Molecular Mechanisms and Treatment Of Autoimmunity In Man And Animal Models


PROJECT_TERMS: Allergic;Antigens;Apoptosis;Autoimmune;Autoimmune Diseases;Biological Process;Candidate Disease Gene;candidate identification;Cell Death;Cell Death Induction;Cell Survival;Cells;Cessation of life;Coin;Contracts;CRISPR/Cas technology;Disease;Embryonic Development;Equilibrium;Event;experimental study;Genes;genome-wide;Graft Rejection;Homeostasis;Human;Immune response;Immune system;Immunity;Immunosuppressive Agents;interest;Knock-out;Libraries;Life;Lymphocyte;Lymphoproliferative Disorders;Medicine;Methods;Molecular;Mus;Outcome;Pathway interactions;Phase;Process;Proliferating;Proteins;Reagent;receptor;Resources;Rest;screening;side effect;Signal Transduction;Specificity;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;therapeutic development;Therapeutic Intervention;therapeutically effective;Viral

PROJECT_TITLE: Molecular Pathways of Programmed Cell Death  And Viral Cytopathicity


NIH_SPENDING_CATS: Genetics

PI_NAMEs: FARBER, JOSHUA M (contact)

PROJECT_TERMS: Agonist;antagonist;Autoimmune Diseases;Bacteria;Binding Sites;Biological;Biological Process;Blood;Blood Vessels;CCR6 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Line;cell motility;cell type;Cells;chemokine;chemokine receptor;Chromatin;circadian;Circadian Rhythms;Communicable Diseases;counterregulation;cytokine;Dermis;Disease;DNA Methylation;driving force;Endothelial Cells;Epidermis;Experimental Models;experimental study;Extravasation;Family;G-Protein-Coupled Receptors;Gene Expression Profiling;gene regulatory network;Genes;genome-wide analysis;Goals;Health;Hematopoietic;Host Defense;Human;Human Activities;Immune response;Immune system;immunopathology;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;interest;intravital microscopy;Investigation;knock-down;Knockout Mice;Leukocyte Trafficking;Leukocytes;Ligands;Maintenance;Malignant Neoplasms;Mediating;member;Memory;memory CD4 T lymphocyte;microorganism;migration;Molecular;mouse model;Mouse Strains;Mucous Membrane;Mus;novel;overexpression;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Population;Process;programs;Proteins;Psoriasis;receptor;Research;response;Role;Site;Skin;Stimulus;Subgroup;Surface;System;T cell differentiation;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Tissues;trafficking;transcription factor;Translating;Tuberculosis;Work

PROJECT_TITLE: Activities Of Chemokines In Health and Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: RAO, V KONETI  (contact)

PROJECT_TERMS: 1 year old;Adult;Affect;Algorithms;Apoptosis;apoptosis in lymphocytes;Autoimmune;autoimmune lymphoproliferative syndrome;Autoimmunity;autoinflammatory;bench to bedside;Biological Response Modifier Therapy;Biology;Blood;Blood Cells;Candidate Disease Gene;Cell Death;Cells;Cellular biology;Child;Childhood;Chronic;Classification;Clinic;Clinical;Clinical Trials;cohort;Collaborations;CTLA4 gene;cytopenia;Data;Defect;Development;Disease;DNA analysis;DNA Sequence Alteration;DNA sequencing;Dose;Dose Limiting;Double-Blind Method;efficacy study;Enrollment;Epigenetic Process;Etiology;exome;experimental study;follow-up;Gene Targeting;Genes;Genetic;genetic analysis;Genetic Diseases;genetic disorder diagnosis;genetic variant;Genomics;Germ Cells;Goals;Grant;Hematology;Histopathology;Homeostasis;Human Genetics;Hypersensitivity;Hypersplenism;Immune;immune activation;immune modulating agents;Immune system;Immune System Diseases;immunodeficiency;Immunologics;Indolent Clinical Course;inhibitor;insight;International;Journals;Juvenile Myelomonocytic Leukemia;Knowledge;KRAS2 gene;Licensing;lymph nodes;lymphadenopathy;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Malignant lymphoid neoplasm;Manuscripts;Mediating;meetings;Molecular;Monocytosis;mouse model;Multi-Institutional Clinical Trial;Mutation;Myelogenous;Natural History;Non-Malignant;novel;novel marker;novel therapeutics;older patient;open label;Outcome;Paper;participant enrollment;PASLI disease;Pathogenesis;Pathogenicity;Pathway interactions;patient subsets;Patients;Pharmacological Treatment;phase III trial;Phosphatidylinositols;Phosphotransferases;PIK3CG gene;Placebo Control;placebo controlled study;Plasma;prevent;Process;Protein Kinase;Publishing;Randomized;randomized placebo controlled trial;rare genetic disorder;recruit;Refractory;Research;Role;Safety;safety assessment;Schedule;senescence;Serum;Signal Pathway;small molecule;Somatic Cell;Somatic Mutation;specific biomarkers;Splenomegaly;STAT3 gain of function;STAT3 gene;Syndrome;System;T cell differentiation;T-cell receptor repertoire;T-Lymphocyte;targeted therapy trials;targeted treatment;Therapeutic Intervention;therapeutic target;therapy duration;Thymus Gland;TLR8 gene;tool;Toxic effect;transcriptomics;Validation;Variant;Vitamin B 12

PROJECT_TITLE: Clinical, Immunological and Genetic  Analyses of ALPS and Related Immunedysregulatory Disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PROJECT_TERMS: Acetylation;Advanced Development;Alcohols;animal facility;Animal Model;Animals;anti-microbial peptide;Antibiotics;Antitubercular Agents;Bacille Calmette-Guerin vaccination;Bacteria;bacterial metabolism;Barbering;Benchmarking;bevacizumab;black hole;Blood Vessels;Callithrix;Cell Wall;chemotherapy;Clinical assessments;Clinical Research;Clinical Trials;Collaborations;cytokine;Data;Deoxyglucose;Development;Disabling;Disease;Disease Progression;Dose;drug candidate;Drug Combinations;Drug Delivery Systems;drug distribution;drug efficacy;Drug Kinetics;drug testing;enzyme activity;Enzymes;Eukaryotic Cell;experience;Experimental Animal Model;Extracellular Matrix;FDA approved;fluorodeoxyglucose;Foundations;Functional Imaging;Gene Expression;Genes;Genus Mycobacterium;Goals;Granuloma;Human;human data;Image;Imaging Techniques;Immunologics;improved;in silico;in vivo;Individual;Infection;Infection Control;Inflammation;Inflammatory;inflammatory marker;inhibitor;Kinetics;Knowledge;Label;Lesion;Linezolid;Losartan;Lung;Maintenance;Mammalian Cell;Manuscripts;Mediating;metabolic abnormality assessment;Metabolism;Modeling;Modernization;Monitor;Moxifloxacin;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nitroimidazoles;nonhuman primate;novel therapeutics;Organ;Organism;Oryctolagus cuniculus;Outcome;Oxazolidinones;Pathology;Patients;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Positron-Emission Tomography;Pre-Clinical Model;predictive modeling;Prodrugs;Production;quinoline;radiotracer;rational design;Regimen;Reporter;Reporting;response;Role;Safety;secondary metabolite;Series;small molecule;Spatial Distribution;structural imaging;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Tracer;transcriptome sequencing;treatment effect;Treatment Protocols;treatment response;Trehalose;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs;tuberculosis granuloma;tuberculosis treatment;uptake;Work;X-Ray Computed Tomography

PROJECT_TITLE: Experimental Animal Models of TB: Chemotherapeutics and Imaging


PI_NAMEs: KEHRL, JOHN H (contact)

PROJECT_TERMS: Acceleration;Adhesions;Automobile Driving;B Cell Proliferation;B-Cell Activation;B-Cell Development;B-Lymphocytes;Behavior;beta-arrestin;Binding;Biological Assay;Blood;Blood Vessels;Bone Marrow;Breeding;C-terminal;C2 Domain;Calcium;cell assembly;Cell Line;Cell membrane;cell motility;Cell Polarity;Cell Surface Receptors;cell type;Cells;Cellularity;chemokine;chemokine receptor;Chemotactic Factors;Chemotaxis;Chimera organism;Chromosome 1;Complex;CRISPR/Cas technology;CXCL13 gene;Data;Defect;density;desensitization;dimer;Dissociation;Elements;Embryo;Endothelium;Event;Exhibits;F-Actin;G-Protein-Coupled Receptors;Gene Cluster;Genes;Goals;GTP Binding;GTP-Binding Protein alpha Subunits;GTP-Binding Protein Regulators;GTP-Binding Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hela Cells;Heterotrimeric GTP-Binding Proteins;Human;Humoral Immunities;Image;Immune;Immunoglobulin A;Impairment;in vivo;Individual;Inflammatory;inhibitor;Injections;insertion/deletion mutation;insight;Intercellular adhesion molecule 1;interstitial;intravital imaging;Investigation;Knockout Mice;Lamina Propria;Lateral;Ligand Binding;link protein;lymph nodes;Lymphatic;Lymphocyte;Lymphopenia;Lysine;Mammalian Cell;Mediating;Methodology;Microscopy;migration;Minor;Motility;Mus;N-terminal;Nonmuscle Myosin Type IIA;Nucleotides;Pathway interactions;Peyer's Patches;PH Domain;pharmacologic;Phenotype;Phospholipase C;Phosphotransferases;PIK3CG gene;Play;Property;Protein Family;Proteins;Proto-Oncogene Proteins c-akt;pup;ras GTPase-Activating Proteins;receptor;Receptor Signaling;recruit;response;Rest;RGS Proteins;Role;Sepharose;Sequence Homology;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Sinus;Splenomegaly;success;T-Lymphocyte;Thick;Time;transmission process;Western Blotting;Wild Type Mouse;wortmannin

PROJECT_TITLE: Control of G-protein Signaling: Role of RGSs


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

PROJECT_TERMS: Activated Natural Killer Cell;Adoptive Transfer;Affect;Alanine;Alleles;Anhidrosis;Annual Reports;Antibody-Producing Cells;Autoimmune Diseases;autoinflammatory diseases;Autophagocytosis;autosome;B-Lymphocytes;biological adaptation to stress;c-myc Genes;Calcium;Cancer Biology;cancer type;Cell membrane;cell motility;Cell Physiology;Cell Polarity;Cell Size;Cell Surface Receptors;Cell Volumes;Cells;chemokine receptor;chloride-cotransporter potassium;Complex;Coupled;CRISPR/Cas technology;Crohn's disease;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Disease;DNA;Edema;EIF-2alpha;Enterobacteria phage P1 Cre recombinase;Exhibits;Exposure to;extracellular;F-Actin;Failure;Family;Family member;Flow Cytometry;FOXO1A gene;gain of function;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Transcription;germinal center kinases;Gram-Negative Bacteria;Headache;Host Defense;Hour;Immune;Immune response;Immunity;Immunoglobulin A;Impairment;Inflammasome;Inflammation;Inflammatory;Inherited;inhibitor;Innate Immune System;Integration Host Factors;interest;Interferon Type I;Interferons;Interleukin-2;Ions;kinase inhibitor;Knock-in;LATS1 gene;LATS2 gene;Leprosy;light scattering;Link;Liquid substance;LoxP-flanked allele;LRRK2 gene;Lymphocyte;lymphoid organ;Lysine;Lysosomes;Macrophage;Mediating;Mediation;member;Metabolism;migration;Motility;mRNA sequencing;mTOR inhibition;Mucosal Immunity;Mus;mutant;Mutate;Mutation;Natural Immunity;Natural Killer Cells;Neoplasm Metastasis;NF-kappa B;Optic Nerve;Organism;Osmoregulation;Osmosis;Osmotic Pressure;Oxidative Stress;Parkinson Disease;pathogen;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Phospholipase C;Phospholipases A;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Play;Process;Production;Proline;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;Protons;receptor;Reporting;response;Rest;Retinal Dystrophy;Risk Factors;RNA;Role;Second Messenger Systems;Serine;Side;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Site;solute;Splenomegaly;Stress;symporter;synergism;Testing;Threonine;Tissues;TRAF2 gene;transcription factor;tumor;Tyrosine Phosphorylation

PROJECT_TITLE: Signal Transduction In B Lymphocytes and Macrophages: Identification Of Key Signaling Molecules


NIH_SPENDING_CATS: Infectious Diseases;Prevention

PI_NAMEs: KWON-CHUNG, KYUNG  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Agrobacterium;Air;Alanine;Amino Acids;Animals;Antibodies;antimicrobial;Australia;Autoantibodies;base;Biological;Biology;Brain;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Central Nervous System;China;Classification;Clinical;Containment;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Data;Defense Mechanisms;Disease;Drug resistance;Ecology;Environment;Epidemiology;Etiology;Extravasation;Feedback;fluorescein isothiocyanate dextran;Frequencies;fungus;Genes;genetic makeup;Genomics;Granulocyte-Macrophage Colony-Stimulating Factor;Granuloma;Host-Parasite Relations;Immune response;Immunocompetent;Immunocompromised Host;Immunoglobulin G;Immunologic Factors;Immunologics;Individual;Infection;Inflammatory;Interferons;Interleukin-1;Interleukin-6;Intravenous;Invaded;Iron;Libraries;Liquid substance;Lung;Macroglobulins;Macrophage;Mediating;Molecular;Mus;mutant;Mycoses;Names;Natural Killer Cells;Nitrogen;Organ;Pathogenicity;Patients;Pattern;Plasma;Predisposing Factor;prevent;Proline;recruit;Risk;Risk Factors;Role;Sampling;Serum;Serum Iron Level;Serum Proteins;Siblings;Signal Transduction;Source;Structure;therapeutic target;tool;Vascular Permeabilities;Virulent

PROJECT_TITLE: Pathogenic differences between Cryptococcus neoformans and C. gattii


NIH_SPENDING_CATS: Asthma;Genetics;Lung

PI_NAMEs: DRUEY, KIRK M (contact)

PROJECT_TERMS: Acceleration;Adenylate Cyclase;Allergens;Allergic;Allergic inflammation;allergic response;Area;Asthma;Basophils;Binding;Biochemical;cell growth;cell motility;Cell Proliferation;Cells;chemokine;Clinical;Coupled;Cyclic AMP;desensitization;Development;disease phenotype;Effector Cell;Extrinsic asthma;Family;G(q) Alpha;G-Protein-Coupled Receptors;Gene Deletion;genetic approach;Germ-Line Mutation;GNAI2 gene;Goals;granulocyte;GTP Binding;GTP-Binding Protein alpha Subunits;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Protein Regulators;GTP-Binding Proteins;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hereditary Disease;Heterotrimeric GTP-Binding Proteins;Human;human subject;Immune;Immunity;immunodeficiency;Impairment;Inflammation;Inflammatory;Investigation;Knowledge;Laboratories;leukocyte activation;Leukocyte Trafficking;Leukocytes;Ligands;Lung;Lymphocyte;MAP Kinase Gene;mast cell;Mediating;Modeling;Mus;mutant;Mutation;neutrophil;novel;overexpression;Pathway interactions;Patients;Phenotype;Physiological;PIK3CG gene;Process;Production;Property;Proteins;Proto-Oncogene Proteins c-akt;Pulmonary Inflammation;receptor;Receptor Activation;Receptor Signaling;recruit;release of sequestered calcium ion into cytoplasm;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;T-Cell Receptor;Time;trafficking

PROJECT_TITLE: Heterotrimeric G Protein Signaling In Allergic Inflammation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: PRIOLA, SUZETTE ALISE (contact)

PROJECT_TERMS: Ablation;Acute;Address;Affect;Alzheimer's Disease;Amino Acids;Animals;Annual Reports;Apoptosis;Autophagocytosis;Axon;axonal degeneration;Biochemical;Biological Assay;Bovine Spongiform Encephalopathy;Brain;Cells;Cellular Stress;Chronic Wasting Disease;Clinical Treatment;Collaborations;Creutzfeldt-Jakob Syndrome;Data;Deer;Development;Diet;Disease;disease phenotype;Disease Progression;Equine mule;Event;experimental study;Genus Hippocampus;Great Britain;Health;Hospitals;Human;Iatrogenesis;Immunohistochemistry;Impairment;in vivo;Infection;Infectious Agent;inhibitor;Knowledge;Laboratories;Manuscripts;Mass Spectrum Analysis;Measures;Mediating;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Biology;Molecular Genetics;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Oxidation-Reduction;Parkin;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Phenotype;PINK1 gene;Post-Translational Protein Processing;Postdoctoral Fellow;Predisposition;Preparation;Prion Diseases;Prions;Process;Production;Prophylactic treatment;protective effect;protein aggregation;protein misfolding;protein transport;Proteins;Protocols documentation;PrP;PrPSc Proteins;Public Health;Publishing;Reactive Oxygen Species;Regulation;Research;Resistance;Respiration;response;Retina;Rodent;Role;Sampling;Scrapie;secretory protein;Sheep;Sterilization;System;Techniques;Therapeutic;therapeutically effective;trafficking;Transgenic Mice;transmission process;Vaccination;Western Blotting;Work

PROJECT_TITLE: Molecular Genetics Of Scrapie Pathogenesis


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PI_NAMEs: GERMAIN, RONALD N (contact)

PROJECT_TERMS: Adjuvant;Affect;Affinity;Animals;Antibody Response;Antibody-mediated protection;Antigen Presentation;Antigen-Presenting Cells;Antigens;Architecture;Atlases;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;autoreactivity;B-Lymphocytes;Bacteria;Behavior;Binding;Biology;Blood;Bone Marrow;cancer cell;cancer immunotherapy;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD80 gene;Cell Communication;cell cortex;Cell Cycle;cell type;Cells;central tolerance;Chicago;Chronic;Collaborations;combat;Complex;Computer Models;Consumption;CRISPR/Cas technology;CTLA4 gene;cytokine;Data;Dendritic Cells;deprivation;Development;Effector Cell;Engineering;Enhancers;Epithelial Cells;Event;expectation;Feedback;fungus;Generations;Genetic;Genotype;Goals;Homeostasis;Human;IL2RA gene;Image;image registration;imaging platform;Immune;immune checkpoint blockade;Immune response;Immunologic Memory;In Situ;In Vitro;Infection;Inflammation;insight;Interleukin-2;intravital imaging;Laboratories;Ligands;Link;Lymphocyte;Lymphoid Tissue;Maintenance;MAPK8 gene;Maps;mathematical model;Mediating;Memory;Methods;Microscopy;migration;mimetics;minimal risk;Minor;Molecular;Monitor;Movement;multiplexed imaging;Mus;NF-kappa B;nuclear factors of activated T-cells;p38 Mitogen Activated Protein Kinase;p65;pathogen;Pathology;Pathway interactions;Pattern;PD-1/PD-L1;Peptide/MHC Complex;Peripheral;Phenotype;Plasma Cells;Play;Predisposition;Prevention;Production;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Property;Protozoa;Regulation;Regulatory T-Lymphocyte;Reporter;Reporting;Research;Research Personnel;response;Rest;Role;sample fixation;Scientist;selective expression;Shapes;Signal Transduction;Site;Software Tools;Specificity;Statistical Data Interpretation;Structure;Structure of germinal center of lymph node;T cell differentiation;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Theft;Three-Dimensional Imaging;Thymus Gland;Time;Tissue imaging;Tissues;tumor;tumor microenvironment;Up-Regulation;Vaccination;Vaccine Design;Vaccine Research;Viral Cancer;Virus;Virus Diseases;Work

PROJECT_TITLE: Functional Biology Of T Cells


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Hematology;Human Genome;Lymphatic Research;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Abdominal Pain;Affect;Anaphylatoxins;Animal Experiments;Antibodies;Apoptosis;Autoimmune;Autoimmune Diseases;autoimmune lymphoproliferative syndrome;autoimmune pathogenesis;Autoimmune Process;autosome;Binding;Biochemical;Candidate Disease Gene;casein kinase II;CD55 Antigens;Cell Aging;Cell Death;Cell Line;Cells;Ceramides;Cessation of life;China;Clinical;clinical diagnostics;clinical investigation;Clinical Protocols;Clinical Research;Clinical Trials;comparative genomic hybridization;Complement;Complement 3 Convertase;Complement 3d;Complement Membrane Attack Complex;congenital immunodeficiency;cost;Cytolysis;Deposition;Deterioration;Development;Diabetes Mellitus;Diarrhea;dihydroceramide desaturase;Disease;DNA Sequence Alteration;DNA sequencing;early onset;Edema;effective therapy;Endothelial Cells;Enrollment;Equilibrium;Evaluation;exome sequencing;Failure;Family;Flare;Gene Mutation;Genes;Genetic;Genetic Diseases;Genetic study;genetic variant;Genomics;Guanosine Triphosphate Phosphohydrolases;gut inflammation;healthspan;Homeostasis;Human;Hypoproteinemia;Immune;immune function;Immune system;Immune System Diseases;immunodeficiency;Immunoglobulins;Immunologic Deficiency Syndromes;Immunologics;immunoregulation;immunosenescence;India;Infection;Infectious Agent;Inflammatory;insight;interest;Intravenous;Investigation;Link;Liver Dysfunction;Longevity;lymph nodes;Lymphangiectasis;Lymphatic;Lymphocyte;lymphoid organ;Malabsorption Syndromes;Malignant lymphoid neoplasm;Mammals;Mediating;Meleagris gallopavo;Molecular;Molecular Abnormality;Monoclonal Antibodies;mortality;Multiple Sclerosis;Mutation;Names;National Institute of Allergy and Infectious Disease;next generation;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;precision medicine;prevent;Process;programs;protein expression;Protein Kinase;Protein-Losing Enteropathies;Protocols documentation;Reaction;reconstitution;Recovery;recurrent infection;Regulation;Reporting;Rheumatoid Arthritis;Scientist;selective expression;Serum Albumin;side effect;subcutaneous;Swelling;Symptoms;Syndrome;T-Lymphocyte;Technology;Therapeutic;Thrombosis;Tissues;transcriptome;transcriptome sequencing;United States Food and Drug Administration;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Molecular Mechanisms Of The Autoimmune Lymphoproliferative Syndrome And Other Immunoregulatory Disorders


PI_NAMEs: NUTMAN, THOMAS  (contact)

PROJECT_TERMS: airborne allergen;Allergens;Allergic;Allergic inflammation;allergic response;Antibodies;Antigens;Ascaris;asthmatic;atopy;Barbering;Basophils;Bystander Effect;CCL11 gene;CCL24 gene;CD30L;Cells;Chronic;Clonal Expansion;cohort;Collaborations;Color;cytokine;Data;Development;Disease;Down-Regulation;Effector Cell;effector T cell;eosinophil;Eosinophilia;eosinophilic inflammation;Eotaxin;Fibroblasts;filaria;Flow Cytometry;Frequencies;Gene Expression Profile;helminth infection;Helminths;Heterogeneity;Human;Hygiene;Hypersensitivity;IgE;IgG1;IgG4;IL13 gene;IL4 gene;IL5 gene;Immune response;Immunoglobulins;Impairment;In Vitro;Individual;Infection;Inflammation;Inflammation Mediators;insight;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-9;Interleukins;KLRB1 gene;Lung;Lymphoid Cell;Macrophage;Maps;mast cell;Mediating;Memory;memory CD4 T lymphocyte;Modeling;Molecular;monocyte;mouse model;Mucous Membrane;Mus;National Institute of Allergy and Infectious Disease;Nematoda;neutralizing antibody;novel;Parasites;Pathogenesis;Pathogenicity;Patients;Phase;Phenotype;Play;Population;prevent;Process;Production;Pulmonary Inflammation;Regulation;response;Role;self organization;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Sorting;Structure of parenchyma of lung;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;terminally differentiated effector memory (TEM) T cells;Th2 Cells;Tissues;tool;trafficking

PROJECT_TITLE: Th2-associated responses and their control in parasitic helminth infections and related disorders


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: RIBEIRO, JOSE  (contact)

PROJECT_TERMS: Acid Phosphatase;Address;Adult;Aedes;Animals;Anti-Inflammatory Agents;Argasidae;arm;Arthropods;Artificial Feeding;Biogenic Amines;Bioinformatics;Biological;Biological Assay;Biology;Blood;Blood coagulation;Blood Platelets;Blood Proteins;Borrelia;Brazil;Castor Bean Tick;Cattle;cDNA Library;Cell Line;Chemicals;Chromatography;co-infection;Coagulation Process;Collaborations;Complement;Complex;Crithidia;Culicidae;Diagnosis;Diet;Disease Vectors;Eukaryotic Cell;European;Evolution;Experimental Designs;Fat Body;feeding;Fleas;Future;Genome;Goals;Greek;Hemolymph;Hemorrhage;Hemostatic Agents;Hemostatic function;Immune;Immune response;immunoreaction;immunoregulation;in vitro testing;in vivo;Individual;Injury;Insecta;insight;interest;Invaded;Laboratories;Learning;Leishmania infantum;Leukotrienes;Lyme Disease;Magic;Maps;member;Methodology;Methods;Midgut;Modification;Molecular Biology;National Institute of Allergy and Infectious Disease;novel;Organism;Ornithodoros;pathogen;Peptides;pharmacologic;Pharmacologic Substance;Phlebotominae;Physiological Processes;Plague;Platelet aggregation;prevent;Process;programs;Property;Protein Family;Proteins;Proteome;Proteomics;Publications;Reaction;Recombinants;Refractory;Relapse;Research;Rhipicephalus;Saliva;Salivary;Salivary Glands;Salivary Proteins;Site;skills;success;sucking;System;Techniques;tick feeding;Ticks;Time;transcriptome;transcriptomics;transmission process;vaccine development;Vaccines;vasoconstriction;Vasodilator Agents;vector;vector tick;Vector-transmitted infectious disease;Visceral Leishmaniasis;Work

PROJECT_TITLE: Vector-Borne Diseases: Biology Of Vector Host Relationship


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: MOIR, SUSAN  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Annual Reports;Antibodies;Antibody Repertoire;Antibody Response;Antibody Therapy;Antibody titer measurement;Antigens;antiretroviral therapy;Architecture;arm;Autologous;B-Lymphocytes;Binding;booster vaccine;Cell Culture Techniques;Cell Lineage;Cell Physiology;Cell surface;Clinical;Clinical Research Protocols;Cloning;COVID-19;Cryoelectron Microscopy;design;Detection;Development;Disease;Disease Progression;Dose;Early identification;Ebola;Ebola Vaccines;Emerging Communicable Diseases;Enrollment;experience;experimental study;Family;Flow Cytometry;Follow-Up Studies;Formalin;Genomics;Glycoproteins;Goals;Health;HIV;HIV Antibodies;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;Human;imaging platform;immune function;Immune response;immunogenicity;Immunoglobulin G;Immunoglobulin M;Immunologics;Immunology;In Vitro;indexing;Interruption;Knowledge;Life Cycle Stages;lymph node biopsy;Lymph Node Tissue;Lymphoid;Lymphoid Tissue;Maryland;Measures;Memory B-Lymphocyte;Metalloproteases;Mutation;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;neutralizing antibody;Outcome;Paraffin;Participant;Pathogenesis;peripheral blood;Persons;Phase;Phenotype;Pilot Projects;Placebo Control;placebo group;Plasma;Plasma Cells;prevent;Process;Property;Proteins;Recombinants;Recommendation;Regulation;Reporting;Research;Research Personnel;Resistance;Resistance profile;Resources;response;RNA;RNA Stability;RNA vaccination;RNA vaccine;Role;Safety;Sampling;screening;Serology;Serum;Severe Acute Respiratory Syndrome;Somatic Mutation;Specimen;superinfection;Technology;Therapeutic Intervention;Time;transcriptomics;Universities;Vaccination;vaccine platform;Vaccines;Vesicular stomatitis Indiana virus;Viral;Viral reservoir;Viremia;Virus;Visualization;Zaire Ebola virus

PROJECT_TITLE: Role of B Lymphocytes In HIV Infection And Pathogenesis


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Rare Diseases;Vaccine Related

PI_NAMEs: KELSALL, BRIAN  (contact)

PROJECT_TERMS: acquired immunity;Acute;Affect;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Automobile Driving;B cell clonality;B-Lymphocytes;Bacteria;base;Blood;Blood specimen;Blood Vessels;Cell Differentiation process;Cell Physiology;Cell Separation;Cells;Cholera Toxin;Colitis;Collaborations;Colon;commensal bacteria;commensal microbes;Complex;Crohn's disease;cytokine;Defect;Dendritic Cells;Development;dextran sulfate sodium induced colitis;Disease;effector T cell;enteric infection;Epithelial Cells;Experimental Models;experimental study;Exposure to;Flow Cytometry;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;genome wide association study;Goals;gut inflammation;gut microbiota;Heterogeneity;Homeostasis;Humoral Immunities;IL6 gene;Immune;Immune response;Immune system;Immunity;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunoglobulin A;Immunoglobulin Class Switching;Immunosuppression;In Situ;in vitro Assay;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-10;Interleukin-6;Intestines;knockout gene;Knockout Mice;Laboratories;Lamina Propria;lymphatic drainage;Lymphoid Follicle;Macrophage;Memory B-Lymphocyte;Messenger RNA;Methods;microbial products;migration;Modeling;Molecular;monocyte;Mononuclear;mouse model;mRNA Expression;Mucosal Immune Responses;Mucous Membrane;Mus;Myeloid Cells;Natural Immunity;novel;oral vaccine;Organism;Outcome;pathogen;Pathogenicity;Pathway interactions;Patients;Peripheral;Peyer's Patches;Phagocytes;Phenotype;Physiological;Play;Population;population based;Post-Transcriptional Regulation;posttranscriptional;Predisposition;Production;protein expression;Proteins;Pulmonary Inflammation;receptor;Regulation;Regulatory T-Lymphocyte;Reovirus;repaired;Resolution;response;Rest;Role;Sampling;Silicosis;single-cell RNA sequencing;Skin;Surface;Susceptibility Gene;T cell differentiation;T cell response;T-Lymphocyte;Time;Tissues;TNF gene;Ulcerative Colitis;uptake;Vaccination;Vaccines;Vibrio cholerae infection

PROJECT_TITLE: Antigen Processing And Presentation In The Intestine


PI_NAMEs: CHUN, TAE-WOOK  (contact)

PROJECT_TERMS: Acute;Address;Adherence;Affect;Anti-Retroviral Agents;antiretroviral therapy;Biological Markers;CD4 Positive T Lymphocytes;Cell Count;Cells;Chronic;Chronic Phase;Clonal Expansion;cohort;CPG-oligonucleotide;cytotoxic;cytotoxicity;Data;Development;Disease;Disease remission;DNA;DNA Folding;Effector Cell;exhaustion;experience;FCGR3B gene;Frequencies;Goals;Health;high dimensionality;HIV;Immune;Immunity;Immunologic Markers;Immunologics;improved;Infection;interest;Interruption;Life Expectancy;longitudinal analysis;Mediating;Mucous Membrane;Natural Immunity;Natural Killer Cells;novel therapeutic intervention;novel therapeutics;Participant;Pathogenesis;perforin;peripheral blood;Persons;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Play;Primary Infection;programmed cell death ligand 1;Proviruses;Research;Residual state;RNA;Role;Sequence Analysis;study population;T-Cell Activation;T-Lymphocyte;Time;viral rebound;Viral reservoir;Viremia;Virion;Virus

PROJECT_TITLE: Role of Viral Reservoirs in the Pathogenesis of HIV Disease


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: CONNORS, MARK  (contact)

PROJECT_TERMS: Acceleration;Alleles;Antigens;antiretroviral therapy;Area;Autologous;Benchmarking;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;cell killing;Cells;chronic infection;cohort;Conserved Sequence;cytotoxic;cytotoxicity;Data;Detection;Development;Disease Progression;Epitopes;experience;Frequencies;Genetic;Goals;HIV;HIV Infections;HIV vaccine;HIV-1;Immune;immune function;Immune response;Immune system;Immunity;Immunologics;Immunotherapy;In Vitro;Individual;Infection;insight;Lentivirus;Link;Maintenance;Measurable;Measures;Mediating;Methods;milliliter;Modeling;Nature;patient response;patient subsets;Patients;Peptides;perforin;Plasma;Process;Proliferating;protective allele;protective effect;Reporting;response;Sampling;segregation;SIV;Specificity;T cell response;T-Lymphocyte;Vaccinated;Vaccination;vaccine development;Vaccinee;Vaccines;viral RNA;Viral Vector;Virus;Virus Replication;Work

PROJECT_TITLE: Mechanisms Of Immune Mediated Restriction Of HIV Replication In LTNP


PI_NAMEs: LOBANENKOV, VICTOR  (contact)

PROJECT_TERMS: 16q22;3-Dimensional;acronyms;Address;Affect;Algorithms;Animals;Apoptosis;Architecture;base;Binding;Binding Sites;Biological;Boundary Elements;Brothers;cancer cell;Cancer Center;cancer/testis antigen;CCCTC-binding factor;Cell Lineage;Cell Nucleus;Cell Proliferation;cell type;Cells;Cessation of life;ChIP-seq;Chromatin;Chromatin Loop;Chromosomes;Clinical;Code;Codon Nucleotides;cohesin;Collaborations;combinatorial;Communication;Communities;Complex;Data;Data Set;Development;Disease;Distal;Distant;DNA;DNA Binding Domain;DNA Methylation;DNA Polymerase II;DNA Sequence;DNA-Binding Proteins;DNase-I Footprinting;dosage;Drosophila genus;Elements;encryption;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Eukaryota;Evolution;falls;Fertility;Fertilization;Fingers;fly;Future;Gene Expression;gene regulatory network;gene repression;Genes;Genetic Code;Genetic Diseases;genetic information;Genetic Transcription;Genome;genome-wide;Genomic Segment;Genomics;Genotype;Germ Cells;Goals;Haploidy;Heritability;Histones;Human;Human Genetics;Human Genome;human subject;immunotherapy trials;imprint;in vivo;Individual;Length;Letters;Link;Literature;Mammalian Cell;Maps;Meiosis;Messenger RNA;Modification;Molecular Biology;monomer;Mothers;mouse genetics;mouse genome;Mus;mutant;Mutate;Mutation;Names;National Institute of Allergy and Infectious Disease;Nature;next generation sequencing;novel;Nucleosomes;Nucleotides;Open Reading Frames;Organism;Paper;paralogous gene;Pathology;Persuasive Communication;Phylogenetic Analysis;Play;postmitotic;Prevention;Process;promoter;Promoter Regions;Protamines;Proteins;Reproduction;Resources;Ribosomes;Role;Sagittaria;Site;Somatic Cell;sperm cell;Spermatids;Spermatogenesis;Spottings;Techniques;Time;transcription factor;Transcription Initiation Site;transcription regulatory network;Transcriptional Activation;Transcriptional Regulation;Translational Research;Translations;Trinucleotide Repeat Expansion;tumor;Untranslated RNA;Viral;Vocabulary;X Inactivation;Zinc Fingers

PROJECT_TITLE: Deciphering CTCF code in mammalian host and viral epigenomes


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases

PI_NAMEs: STROBER, WARREN  (contact)

PROJECT_TERMS: Ablation;activin A;Activins;Address;alpha ketoglutarate;arm;Asthma;asthmatic;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pancreatitis;Autoimmunity;beta-Chemokines;beta-Glucans;Binding;Candida albicans;Cell Communication;Cell Physiology;cell type;Cells;chemokine;chemokine receptor;Cholangitis;Circulation;Citric Acid Cycle;Clinical;Complex;Consumption;CREB1 gene;CXCL10 gene;CXCL9 gene;cytokine;Data;dectin 1;Dendritic Cells;deprivation;Dermatophagoides Antigens;Development;differential expression;Disease;Distal;effector T cell;Enzyme Precursors;eosinophil;Epigenetic Process;Event;Exhibits;Experimental Models;Exposure to;Feedback;Follistatin;FOXP3 gene;FRAP1 gene;GATA3 gene;Generations;Genes;Genetic Transcription;Glutamate Metabolism Pathway;Glutamates;Glutaminase;Glutamine;Helper-Inducer T-Lymphocyte;Histologic;Histone Acetylation;Human;Hyphae;IgE;IgG4;IgG4-related disease;In Vitro;Inflammation;Inflammatory;Inflammatory Bowel Diseases;INHA gene;inhibin;Inhibin A;inhibitor;Injections;Interferon alpha;Interferon Type I;Interleukin-10;Interleukin-4;Laboratories;Ligands;Link;Lysosomes;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic profile;metabolome;migration;Mitochondria;Modeling;Molecular;mouse model;MRL/MpJ Mouse;mTOR Signaling Pathway;Mus;Nature;Norleucine;Organ;Organism;Oxygen Consumption;Pancreas;Pancreatitis;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Permeability;Phenotype;Phosphorylation;Poly I-C;Population;Process;Production;promoter;Protein Isoforms;Pulmonary Inflammation;receptor;Regulation;Regulatory T-Lymphocyte;release factor;Reporting;Research;Respiration;response;Role;Serum;Sialadenitis;Signal Transduction;Site;Source;Stimulant;Study models;systemic autoimmune disease;T cell differentiation;T cell regulation;T cell response;T-Cell Activation;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;TGF-beta type I receptor;Th2 Cells;Time;Tissues;TLR3 gene;Training;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Yeasts;Zymosan

PROJECT_TITLE: Regulation of T cell Differentiation


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: SUN, PETER D. (contact)

PROJECT_TERMS: adhesion receptor;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Apoptotic;Binding;C Type Lectin Receptors;Caspase;Caspase Inhibitor;CD4 Antigens;CD4 Positive T Lymphocytes;Cell surface;Cells;chemokine receptor;Chronic;cytokine;Exhibits;Family;fitness;Goals;HIV;HIV 1 Envelope Protein gp120;HIV Infections;HIV-1;Individual;Infection;inhibitor;L-Selectin;Life Cycle Stages;Mediating;memory CD4 T lymphocyte;Metalloproteases;nef Genes;Pathway interactions;Patients;Phase;Phosphatidylserines;Polysaccharides;Production;receptor;Role;Selectins;SELL gene;sialic acid binding Ig-like lectin;Signal Pathway;small molecule inhibitor;Supporting Cell;T memory cell;Viral;Viral reservoir;Virion;Virus;Virus Activation;Virus Diseases;Virus Shedding

PROJECT_TITLE: Mechanism and pathways controlling HIV-1 viral release


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: DESAI, SANJAY A (contact)

PROJECT_TERMS: Ablation;Acceleration;Adhesions;Agonist;analog;Anions;Anti-malarials;antibody-dependent cell cytotoxicity;Binding;Biological Assay;Biology;biophysical properties;Blocking Antibodies;Blood;Blood Circulation;Buffers;burden of illness;Carrier Proteins;CD58 gene;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cell Separation;Cell surface;Cells;Cellular biology;Chemicals;Collaborations;Communities;Complex;Computational Biology;CRISPR/Cas technology;Culicidae;Cytolysis;Dependence;Development;DNA;drug development;drug discovery;Electron Microscopy;Electroporation;Engineering;Epitopes;Erythrocytes;Evaluation;Excision;Exhibits;experimental study;extracellular;Florida;Flow Cytometry;Future;gene cloning;Gene Family;Genes;Genetic;genetic manipulation;Genetic study;Glutathione;Goals;Growth;high throughput screening;Human;human model;human pathogen;Image Cytometry;Immune;Immunoglobulin G;Impairment;improved;In Vitro;Incubated;Individual;Infection;Inflammation;inhibitor;insight;instrumentation;Integrins;intercellular cell adhesion molecule;Invaded;Ion Channel;Ion Transport;Ions;Killer Cells;knock-down;Knock-out;Ligands;Link;Lipid Bilayers;Lipid Biochemistry;Macrophage-1 Antigen;Malaria;Mediating;member;Membrane;Methods;microorganism;model organism;Molecular;Molecular and Cellular Biology;Molecular Biology;Molecular Chaperones;monocyte;multidisciplinary;Multigene Family;mutant;National Institute of Allergy and Infectious Disease;Natural Killer Cells;novel;novel strategies;Nutrient;paralogous gene;parasite genome;Parasites;pathogen;Peptide Hydrolases;Peptides;Permeability;Phagocytosis;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiological;Physiology;Plasma;Plasmids;Plasmodium;Plasmodium falciparum;Procedures;Process;Property;Protein Biochemistry;Protein Export Pathway;Proteins;reconstitution;Reporter;Research;Resistance;Resources;rhoptry;Role;seal;small molecule libraries;solute;Structure;Structure-Activity Relationship;Study Section;Surface;Symptoms;Synapses;Technology;therapy development;trafficking;transcriptome;Transfection;Transmembrane Transport;uptake;vaccine development;Vaccines;Vacuole;Variant;vector mosquito;Vesicle;Work

PROJECT_TITLE: Cellular and Molecular Physiology of Bloodstream Malaria Parasites


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ARTHOS, JAMES L (contact)

PROJECT_TERMS: acute infection;adaptive immune response;Affinity;Annual Reports;Area;Basic Science;Binding;Biology;CD4 Antigens;CD4 Positive T Lymphocytes;Cell Surface Receptors;Development;Epitopes;Event;Future;Goals;Gut associated lymphoid tissue;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV Receptors;HIV vaccine;Immune;Immunology;Infection;Infection prevention;integrin alpha4beta7;Knowledge;Lymphoid;Mediating;mesenteric lymph node;migration;Mucous Membrane;novel;novel strategies;novel therapeutics;prevent;Prevention;Prevention strategy;programs;Publishing;receptor;receptor binding;Reporting;Research;Role;Site;Surface;T cell regulation;Time;transmission process;Tropism;vaccine development;Viral;Viral reservoir;Virus;Work

PROJECT_TITLE: Interaction of HIV envelope with cell surface receptors


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: CICALA, CLAUDIA  (contact)

PROJECT_TERMS: Acute;CCR5 gene;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Development;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV-1;Immune System Diseases;Immunologic Surveillance;Immunotherapy;In Vitro;Infection;Ligands;lymph nodes;Maintenance;Mediating;Methods;mucosal addressin cell adhesion molecule-1;Mucous Membrane;Pathogenesis;Play;Productivity;Reporting;Research;Role;Signal Transduction;Site;SIV;Testing;tissue resident memory T cell;Tissues;Transforming Growth Factor beta;transmission process;Tretinoin;Tropism;Vaccines;Vascular Cell Adhesion Molecule-1;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Role of HIV Envelope Proteins  In Viral Replication and HIV Pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PI_NAMEs: WHITEHEAD, STEPHEN  (contact)

PROJECT_TERMS: Accounting;Admixture;Antibodies;Asia;Attention;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;attenuation;Basic Science;Binding;Biochemical;Biological Assay;Brain;Brazil;cancer type;Case Study;Cells;Cessation of life;China;Clinical;clinical application;Clinical Distribution;clinical lot;Clinical Research;Clinical Trials;Collaborations;Collecting Cell;Culicidae;Cyclic GMP;Data;Dengue Fever;Dengue Vaccine;Dengue Virus;Development;E protein;Engineering;Epididymis;Epitopes;Evaluation;Family;Flaviviridae;Flavivirus;Formulation;Generations;Genes;Genome;Goals;Harvest;Human;human subject;Immune;Immune response;immunogenicity;Immunology;In Situ;Individual;Infection;Innate Immune Response;Institution;interest;Japanese Encephalitis;Japanese encephalitis virus;Laboratories;Laboratory Study;Length;Licensing;Macaca mulatta;Macrophage;Maintenance;manufacture;manufacturing process development;member;Methods;MicroRNAs;Modeling;Molecular;Monkeys;mosquito-borne;Mus;Mutation;Neutralizing antibody assay;nonhuman primate;Pathogenicity;Pathology;Phase;phase 3 testing;Placenta;preclinical study;Preclinical Testing;Preparation;programs;Proteins;Qualifying;recombinant virus;Recombinants;research clinical testing;Research Personnel;RNA;Role;Saliva;Salivary Glands;Sequence Analysis;Serotyping;Shipping;Southeastern Asia;Sterility;Structure;Syndrome;Techniques;Technology;Tight Junctions;Time;Tissues;trial planning;Untranslated Regions;vaccine candidate;vaccine formulation;vaccine immunogenicity;vaccine platform;Vaccines;Viral;Viral Encephalitis;Viral Pathogenesis;virology;Virulent;Virus;Virus Replication;Visit;West Nile Fever;Work;Yellow Fever;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Laboratory And Preclinical Studies Of Flaviviruses


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: SU, XINZHUAN  (contact)

PROJECT_TERMS: 3-Dimensional;5' Untranslated Regions;Address;Affect;Alleles;Amino Acid Substitution;Amino Acids;Anemia;benflumetol;Candidate Disease Gene;Cell membrane;Cerebral Malaria;Collaborations;Cytoplasm;Development;Disease;Drug resistance;Evaluation;Experimental Designs;experimental study;functional genomics;Gene Expression;Genes;Genetic;Genetic Crosses;Genetic Polymorphism;Genome;genome annotation;genome-wide;genomic locus;Genomics;Genotype;Goals;Human;Immune;Immune response;Immunologics;Impairment;improved;Infection;Interferon Type I;Interruption;Introns;IRF3 gene;Malaria;malaria infection;Malignant Neoplasms;Manuscripts;Maps;Measures;Mediating;Mefloquine;Messenger RNA;Metabolic;Methods;MMP3 gene;Molecular;Motility;Movement;Multi-Drug Resistance;Mus;Mutation;Nucleotides;olfactory receptor;overexpression;Paper;parasite genome;Parasites;Parasitic infection;Pathogenesis;Pharmaceutical Preparations;Phosphorylation;Plasmodium;Plasmodium berghei;Plasmodium yoelii;Play;Proteins;Publications;Published Comment;Publishing;Quantitative Trait Loci;Receptor Gene;Research Project Grants;response;RNA;Role;Signal Pathway;Sporozoites;Suggestion;Symptoms;TBK1 gene;transcriptome sequencing;transmission process;ubiquitin isopeptidase;Ubiquitination;Universities;Vacuole;vector;Virulence;Work

PROJECT_TITLE: Malaria Parasite Genomics, Development, Drug Resistance, Pathogenesis, and host-parasite interaction


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: GREEN, KIM Y. (contact)

PROJECT_TERMS: Acute Diarrhea;Address;age group;Anti-viral Agents;Basic Science;Biological Models;Biopsy;burden of illness;Calicivirus;Cell Culture System;Cell Line;Cells;Characteristics;Child;Chronic;Chronic Disease;chronic infection;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;congenital immunodeficiency;continuous cell line;Data Analyses;Death Rate;Defect;design;diarrheal disease;Disease;Disease Outbreaks;Dissociation;effective therapy;Engineering;Epidemic;exome sequencing;experimental study;Family;Gastroenteritis;Gene Mutation;Genetic Variation;Genome;Genotype;Goals;Human;Immune;immune reconstitution;Immune response;Immunocompromised Host;immunodeficiency;Immunotherapy;improved;Individual;Infection;Institutional Review Boards;Integration Host Factors;Intestines;Intravenous Immunoglobulins;Investigation;Laboratories;Lagovirus;lytic replication;Medical center;member;Modeling;Molecular;Molecular Epidemiology;Monkeys;Morbidity - disease rate;mortality;Mus;National Institute of Allergy and Infectious Disease;Natural History;nitazoxanide;Norovirus;participant enrollment;Pathogenesis;pathogenic virus;Patients;Performance;Play;Population;preclinical study;Prevention;receptor;Recombinants;Reporting;Research;research and development;Research Personnel;Research Support;RNA;RNA Viruses;Safety;Sapovirus;Shock;single-cell RNA sequencing;Specificity;surveillance study;System;T cell therapy;T-Lymphocyte;Techniques;Therapeutic;therapeutically effective;Therapy trial;Time;Tissues;tool;transcriptomics;Translating;Translational Research;United States National Institutes of Health;vaccine development;vaccine trial;Variant;Vesivirus;Viral;Virus;Washington;Work

PROJECT_TITLE: Noroviruses and Epidemic Gastroenteritis


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

PI_NAMEs: PIERCE, SUSAN  (contact)

PROJECT_TERMS: Affinity;Antibodies;antigen challenge;Antigen Presentation;Antigens;autoreactivity;B cell repertoire;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Blood Cells;Calcium;Calcium Channel;CD19 gene;Cell Communication;Cell Compartmentation;Cell membrane;Cell surface;Cells;Cellular biology;Centenarian;Characteristics;cohort;Collaborations;COVID-19 vaccination;design;Dose;Event;experience;fluorescence lifetime imaging;Generations;Germ Lines;Goals;HPV analysis;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus HPV L1 protein;Immune;Immunoglobulin G;Immunoglobulin M;In Vitro;in vivo;Individual;Induction of Apoptosis;Influenza vaccination;influenza virus vaccine;inhibitor;knock-down;Laboratories;Membrane;Memory;memory acquisition;Memory B-Lymphocyte;Molecular;Mutate;Mutation;neutralizing antibody;Older Population;Outcome;pandemic disease;particle;pathogen;peripheral blood;Phenotype;Phosphorylation;Piezo 1 ion channel;Piezo ion channels;Plasma;Plasma Cells;PLCgamma2;Population;prophylactic;recruit;Recurrence;response;Role;Second Messenger Systems;secondary lymphoid organ;single-cell RNA sequencing;Somatic Mutation;Stimulus;Stretching;Structure of germinal center of lymph node;Surface;tool;vaccination strategy;Vaccinee;Vaccines;Variant;Virus-like particle

PROJECT_TITLE: B Cell Biology


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Abdominal Pain;Adverse effects;Adverse event;Agammaglobulinaemia tyrosine kinase;Albumins;Alkaline Phosphatase;anakinra;Anti-Inflammatory Agents;Antibodies;Area;Autoimmune;Autoimmune Hepatitis;B-Cell Activation;B-Lymphocytes;Benign;Biological Response Modifier Therapy;Blood Vessels;Bone Marrow Transplantation;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chronic;Clinical;clinical remission;Clinical Research;clinically significant;cohort;Collaborations;Common Variable Immunodeficiency;Complex;Complication;Crohn's disease;cytokine;Data;Dendritic Cells;Disease;Disease Progression;Disease remission;disorder risk;effective therapy;Enrollment;Environmental Risk Factor;Enzymes;Evaluation;Exhibits;experience;Failure;Feces;FOXP3 gene;Functional disorder;Gamma globulin;gastrointestinal function;Gastrointestinal tract structure;Generations;Genes;Genetic Polymorphism;Goals;gut inflammation;gut microbiome;HDAC4 gene;healing;Hepatic;High Prevalence;Histologic;Histology;Histone Deacetylase Inhibitor;Hyperplasia;hypogammaglobulinemia;IL18 gene;Immune;immunodeficiency;immunological status;Immunologics;Immunosuppressive Agents;Impairment;improved;Individual;Infiltration;Inflammasome;Inflammation;Inflammatory Bowel Diseases;inhibitor;Integrins;Interferon Type II;Interleukin-12;Intestinal Mucosa;Intestines;Intravenous;kinase inhibitor;Laboratories;large bowel Crohn's disease;life span;Liver;Liver diseases;Liver Failure;liver transplantation;LRRK2 gene;Macrophage;Malabsorption Syndromes;Mediating;Medical center;Methods;microorganism;Modality;Modification;Molecular;Molecular Abnormality;Mucosal Immune Responses;Mucosal Immunity;Mucositis;Mucous Membrane;Mutation;Nature;Neutropenia;New York;Nigericin;Organism;Pathologic;patient population;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;Phosphorylation;Phosphotransferases;Portal Hypertension;preservation;Process;Production;Progressive Disease;Proteins;Recording of previous events;recurrent infection;regenerative;Relapse;Reporting;Research;research study;resident commensals;response;Safety;safety study;Severity of illness;Side;side effect;Signaling Molecule;Small Intestines;Source;Splenomegaly;standard of care;Steroid therapy;Study Section;subcutaneous;Subgroup;Suppressor-Effector T-Lymphocytes;Symptoms;T-Lymphocyte;Therapeutic immunosuppression;Thrombocytopenia;Tissues;TNF gene;trafficking;Transaminases;Treatment Protocols;Trypsin;Ulcerative Colitis;Villous Atrophy;virtual;Vorinostat;X-Linked Agammaglobulinemia

PROJECT_TITLE: Clinical Studies of Inflammatory Bowel Diseases


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: OTTO, MICHAEL  (contact)

PROJECT_TERMS: Bacteria;Bacterial Infections;Collaborations;Disease;Genus staphylococcus;Goals;Hospitals;Host Defense;Human;Immune Evasion;Infection;Institution;Invaded;Investigation;Microbial Biofilms;Molecular;pathogen;Pathogenesis;pathogenic bacteria;Phenols;Phenotype;Process;quorum sensing;Research Personnel;Sepsis;Series;Signal Transduction;Staphylococcal Infections;Staphylococcus aureus;Toxin;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Staphylococcal pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

PI_NAMEs: STEELE-MORTIMER, OLIVIA  (contact)

PROJECT_TERMS: Actins;Acute;Affect;Animals;Bacteria;Binding;Biological Models;Biomedical Engineering;Cells;Chemoreceptors;Chemotaxis;Chronic;chronic infection;cohort;Complement;Complex;Cytosol;cytosolic receptor;Disease;Enterocolitis;Environment;Epithelial Cells;Feces;Fluorescence;Frequencies;Gastrointestinal tract structure;Gene Expression;Genes;Genetic Transcription;Goals;Growth;gut colonization;Hela Cells;Human;human model;human pathogen;In Vitro;in vitro Model;Individual;Infection;Inflammation;Integration Host Factors;Interleukin-8;intestinal epithelium;Intestines;Invaded;lytic gene expression;Mediating;Membrane;methyl-accepting chemotaxis proteins;Modeling;Molecular;Motility;Mus;mutant;Natural Resistance;NF-kappa B;oral infection;Oxygen;pathogen;Pathogenesis;Pathogenicity Island;Pathway interactions;Phase;Physiological;Play;polymerization;Polymers;Population;Predisposition;Process;protein expression;Proteins;Regulation;Regulon;Reporting;Role;Salmonella;Salmonella enterica;Salmonella typhimurium;Signal Pathway;Signal Transduction;Swimming;System;trafficking;transcriptomics;Type III Secretion System Pathway;Typhoid Fever;Vacuole;Virulence;Work;Zinc

PROJECT_TITLE: Invasion and intracellular replication of Salmonella Typhimurium in epithelial cells


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Infectious Diseases;Lupus;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: BOLLAND, SILVIA  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Antigen Receptors;Arthritis;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;clinical risk;Collaborations;Development;Diabetes Mellitus;Disease;Double-Stranded RNA;effective therapy;Environmental Risk Factor;fitness;Future;Genes;Genetic;Goals;Human;IgG Receptors;Immune response;Infection;insight;Interferon Inducers;Interferon Type I;Interferons;Investigation;Link;Lupus;Malaria;malaria infection;member;metabolic fitness;Methods;Mitochondria;Molecular;mouse model;Mus;National Institute of Allergy and Infectious Disease;Other Genetics;Pathogenicity;Pathology;Pathway interactions;Patients;Predisposition;pressure;Prevention;programs;Research;Role;sensor;Signal Transduction;systemic autoimmune disease;Systemic Lupus Erythematosus;Therapeutic;TLR7 gene;Viral;viral RNA;Virus Diseases;working group

PROJECT_TITLE: Genetic and Environmental Modifiers Of Autoimmune Disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: COHEN, JEFFREY  (contact)

PROJECT_TERMS: Allogenic;Asia;asparaginase;B-Lymphocytes;Blood;Burkitt Lymphoma;cancer cell;Cells;chemotherapy;Chronic;Complication;curative treatments;Dexamethasone;Diagnosis;Diagnostic;diagnostic criteria;Disease;Early Diagnosis;EBV-associated disease;Epithelial Cells;Epstein-Barr Virus Infections;Etoposide;Europe;Goals;Hematopoietic Stem Cell Transplantation;Hemophagocytic Lymphohistiocytoses;Hodgkin Disease;human disease;Human Herpesvirus 4;Immune response;Immunologics;Infectious Mononucleosis;Infiltration;latent infection;Leukemic Natural Killer Cell;Life;Lymphoma;Modality;Molecular Abnormality;morphological criteria;Multiple Organ Failure;Nasopharynx Carcinoma;Natural Killer Cells;Organ failure;Oropharyngeal;Pathogenesis;Patients;Prognosis;Reporting;response;Role;Severity of illness;Standardization;Stomach Carcinoma;Tissues;United States;Virus;Virus Diseases

PROJECT_TITLE: Epstein-Barr Virus Associated Disorders


PI_NAMEs: JIN, TIAN  (contact)

PROJECT_TERMS: Actins;Amoeba genus;Bacteria;Binding;Binding Sites;Biochemical;Biological Models;Biology;cell motility;Cells;Chemotactic Factors;Chemotaxis;Complex;Computer Assisted;Computer Simulation;Consumption;Coupled;Cues;Cyclic AMP;Cyclic AMP Receptors;Detection;Dictyostelium discoideum;Endowment;Eukaryotic Cell;experimental study;Exposure to;extracellular;fluorescence imaging;folate-binding protein;Folic Acid;Food;G-Protein-Coupled Receptors;Genome;Goals;Heterotrimeric GTP-Binding Proteins;imaging modality;Immunity;Immunoglobulins;Invaded;Invertebrates;Investments;Life;Lipopolysaccharides;Mediating;member;microbial;Modeling;Molecular;Organism;Orphan;Orthologous Gene;particle;pathogen;pathogenic bacteria;Pattern;Pattern recognition receptor;Phagocytes;Phagocytosis;Proteomics;Protozoa;receptor;response;Signal Pathway;Signal Transduction;social;Surface;Techniques;Toll-like receptors;Venus Flytrap;Vertebrates

PROJECT_TITLE: The mechanisms underlying the GPCR-mediated chemotaxis in D. discoideum


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: LEPPLA, STEPHEN  (contact)

PROJECT_TERMS: Affinity;Amino Acids;Animals;Anthrax disease;anthrax toxin;Anthrax Vaccines;Antibodies;anticancer activity;Antigens;Bacillus anthracis;Bacteria;Bacterial Infections;Binding;Biochemical;Biological Assay;Calorimetry;Cell Nucleus;Cell surface;cell type;Cells;Chimeric Proteins;Community Developments;Complex;Cultured Cells;Cytosol;cytotoxicity;Data;Distant;Edema;efficacy evaluation;Engineering;Enterobacteria phage P1 Cre recombinase;Eukaryotic Cell;Genes;Human;improved;Infection;Infection prevention;Intervention;lethal factor;Macrophage;MAP2K1 gene;MEKs;Metalloproteases;Methods;Modeling;Monoclonal Antibodies;Mus;mutant;Mutation;N-terminal;Names;neoplastic cell;Normal tissue morphology;pathogen;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Predisposition;prevent;Property;protein expression;Proteins;Rattus;Reporter;Reporting;research and development;Role;Septic Toxemia;Specificity;Symptoms;System;Testing;Therapeutic;Therapeutic Index;Tomatoes;tool;Toxic Actions;Toxic effect;Toxin;Transcription Coactivator;tumor;Tumor Tissue;Urokinase;vaccine candidate;vaccine efficacy;Vaccines;Variant;Virulence Factors;Work

PROJECT_TITLE: Vaccines and Therapeutics for Anthrax


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: VALENZUELA, JESUS  (contact)

PROJECT_TERMS: Address;adenosine deaminase;Adopted;Aedes;Animal Model;Animals;Anopheles Genus;anti-tick vaccine;Antibodies;Antibody Response;Antigens;arm;asexual;Attenuated;B-Lymphocyte Epitopes;Binding;Biochemical;Bioinformatics;Biological Markers;Biopsy;Bite;Blood;Borrelia burgdorferi;Brazil;Cambodia;Canada;CD8-Positive T-Lymphocytes;Cell fusion;Cellular Immunity;Child;Chimeric Proteins;Clinical Protocols;Cohort Studies;Collaborations;Communicable Diseases;comparison control;Complex;cross reactivity;Culex (Genus);Culicidae;Cutaneous Leishmaniasis;Dengue;Development;disease transmission;disorder control;DNA;Electron Microscope;Elements;Enrollment;Enzyme-Linked Immunosorbent Assay;eosinophil;epidemiology study;Event;exposed human population;Exposure to;Female;fitness;Future;gastrointestinal epithelium;Genetic;Glycoside Hydrolases;Goals;good laboratory practice;Guidelines;Health Sciences;Hematoxylin and Eosin Staining Method;Human;Human Volunteers;Hybrids;Hyperpigmentation;Hypersensitivity skin testing;Immune;Immune response;Immunization;immunogenic;Immunoglobulin G;Immunoglobulin M;Immunologics;improved;In Vitro;in vivo;Incidence;Infection;Infiltration;Ingestion;Insect Bites;Insect Vectors;Integration Host Factors;Interferon Type II;Interleukin-10;Knowledge;Laboratories;large scale production;Leishmania;Leishmania donovani;Leishmania major;Leishmaniasis;leishmanin;lipophosphonoglycan;Lyme Disease;macula;Malaria;Measures;Mediating;Medicine;Membrane;microorganism;Midgut;Mite Controls;Mites;Molecular;Molecular Biology;molecular vector;Mononuclear;Morphology;mortality;mouse model;Mus;National Institute of Allergy and Infectious Disease;natural antibodies;neglect;Nymph;Parasites;Parasitic Diseases;Parasitology;Partner in relationship;pathogen;Pathogenicity;Pattern;Pediatric cohort;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Phlebotominae;Phlebotomus;Plasma;Play;Population;Population Sizes;Production;Productivity;Proteins;Punch Biopsy;Reaction;Recombinant Proteins;Recombinants;Reporting;Research;Resistance;response;RNA vaccination;Role;Route;Saliva;Salivary;Salivary Glands;Salivary Proteins;Sampling;Scanning;Seasons;serosurvey;Serum;Site;Skin;Stains;Standardization;success;Surface;Taxonomy;Testing;tick bite;Tick Infestations;Tick-Borne Diseases;tick-borne pathogen;Ticks;Time;tool;Transcript;Translating;transmission process;United States National Institutes of Health;Universities;University Health Services;Vaccination;Vaccine Clinical Trial;Vaccines;vector;vector-borne;Virulence;volunteer;Western Blotting;whole genome

PROJECT_TITLE: Molecular approaches to understand vector-host and vector-pathogen interactions


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: CHESEBRO, BRUCE  (contact)

PROJECT_TERMS: Animals;Biological Assay;Biology;Brain;brain cell;Brain Injuries;C57BL/10 Mouse;C57BL/6 Mouse;Cells;coisogenic;Cone;Dendrites;design;Disease;DLG4 gene;Electroretinography;Exclusion;experimental study;Focal Adhesions;Genetic Transcription;Gliosis;Host Defense;Human;human disease;Immunohistochemistry;Individual;Infection;Infiltration;Inflammation;Integrins;ITGAX gene;ITGB2 gene;Knockout Mice;Macrophage;Measures;Methodology;Microglia;Minor;Modeling;monocyte;Morphology;Mouse Strains;Mus;Mutation;Nature;Nervous System;Neurodegenerative Disorders;neuroprotection;Optical Coherence Tomography;Pathogenesis;Pathologic;Pathway interactions;Peptide Hydrolases;Phagocytosis;Phase;Photoreceptors;Population;Predisposition;Prevention strategy;Prion Diseases;Prions;protein expression;Proteins;PrP;receptor;Resistance;Resolution;response;Retina;Retinal Cone;ribbon synapse;Signal Transduction;Site;Synapses;Testing;Thick;Time;Tissues

PROJECT_TITLE: Biology of Prion Protein and the TSE Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: BUCHHOLZ, URSULA  (contact)

PROJECT_TERMS: Adult;Adverse event;Aerosols;airway epithelium;Alpha Virus;Animal Experiments;Animals;Antibodies;Antibody Response;Antibody titer measurement;antigen test;Antigens;Attenuated;attenuation;Avian Influenza A Virus;Avulavirus;Biological Assay;Cattle;Cavia;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cells;Child;Chimera organism;Clinical;Clinical Research;cohort;Coronavirus spike protein;Cytoplasm;Data Analyses;design;Development;Dose;Ebola virus;Ebola virus envelope glycoprotein;Effectiveness;emerging pathogen;Engineering;expression vector;Family member;Future;Gene Order;Generations;Genes;Genetic Transcription;Genome;Genomics;Glycoproteins;Helper-Inducer T-Lymphocyte;Human;Immune response;Immunity;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;Infant;Infection;Influenza Hemagglutinin;Inpatients;Intranasal Administration;Lung;Macaca;Macaca mulatta;Measures;Mediating;Membrane Glycoproteins;Membrane Proteins;Messenger RNA;Modification;Mucosal Immunity;Mucous Membrane;Murine pneumonia virus;Mus;Nasal Lavage Fluid;neutralizing antibody;Newcastle disease virus;nonhuman primate;open label;Para-Influenza Virus Type 1;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;Participant;pathogen;pathogenic virus;Pathogenicity;phase 1 study;Phase I Clinical Trials;Placebos;Pneumovirus;Polymerase;Population;Preparation;Primates;Proteins;Public Health Schools;Publications;Quantitative Reverse Transcriptase PCR;Randomized;respiratory;respiratory pathogen;Respiratory syncytial virus;Respiratory System;response;reverse genetics;RNA;Rodent;Route;Safety;safety study;Sampling;SARS coronavirus;seropositive;Serum;Severe Acute Respiratory Syndrome;Signal Transduction;Surface Antigens;System;Testing;Time;tissue tropism;TRIP10 gene;United States National Institutes of Health;Upper respiratory tract;Vaccination;vaccine candidate;vaccine delivery;vaccine development;Vaccines;vector;vector vaccine;vector-based vaccine;Viral;viral detection;Viral Vaccines;Virion;Virus;Virus Replication;Virus Shedding;volunteer;Work

PROJECT_TITLE: Paramyxoviruses as Vaccine Vectors Against Highly Pathogenic Viruses


NIH_SPENDING_CATS: Asthma;Infectious Diseases;Lung

PI_NAMEs: DRUEY, KIRK M (contact)

PROJECT_TERMS: Actins;Adenosine;Adrenal Cortex Hormones;Adrenergic beta-Agonists;Affect;Affinity;aggressive therapy;Agonist;airway hyperresponsiveness;airway obstruction;Albuterol;Allergens;allergic airway inflammation;anti-fungal agents;Area;Aspergillus fumigatus;Asthma;asthma model;asthmatic;asthmatic airway;Autopsy;Binding;Bradykinin;Bronchoconstriction;Bronchodilator Agents;Calcium;Cells;Cessation of life;Collaborations;Coupled;Cyclic AMP;cysteinyl-leukotriene;Disease susceptibility;Drug Targeting;efficacy study;Endothelin-1;eosinophil;eosinophilic inflammation;Exhibits;experience;Experimental Models;Extracellular Matrix;Extrinsic asthma;fungus;G alpha q Protein;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Deletion;Goals;Grant;granule cell;GTP-Binding Protein alpha Subunits;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Protein Regulators;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Hepatitis C;Hepatitis C Therapy;Heterotrimeric GTP-Binding Proteins;Histamine;Human;Hypersensitivity;IgE;In Vitro;in vivo;Infection;Inflammation Mediators;Inflammatory Response;inhibitor;Inhibitory G-Protein Gi;insight;interest;Knock-in Mouse;Knockout Mice;Lead;Leukotriene Antagonists;Leukotriene D4;Life;Ligands;Link;Lung;mast cell;Mediating;Modeling;Molds;Monoclonal Antibodies;mouse model;Mus;Muscle Contraction;Muscle Fibers;Muscle function;Muscle relaxation phase;mutant;Myosin ATPase;Natural Substance;novel;novel therapeutics;omalizumab;PAR-2 Receptor;Pathologic;Peptide Hydrolases;Persons;Physiological;PIK3CG gene;preservation;Proliferating;Proteins;pulmonary function;Pulmonary Inflammation;receptor;Regulation;Relaxation;respiratory;respiratory smooth muscle;RGS Domain;RGS Proteins;Role;Serine Protease;Signal Induction;Signal Pathway;Signal Transduction;Slice;Smooth Muscle;Smooth Muscle Myocytes;Specimen;STAT1 gene;success;Therapeutic;Therapeutic Uses;Thrombin;Tissue Banks;Tissues

PROJECT_TITLE: Regulation of Normal and Asthmatic Lung Function by G-Protein-Coupled Receptors


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: BLOOM, MARSHALL ELLIOTT (contact)

PROJECT_TERMS: Acinus organ component;acute infection;Adult;Alaska;Allergic Reaction;alpha helix;Amino Acid Sequence;anatomic imaging;Animal Model;Anti-viral Agents;Appearance;Area;Argas;Arthropods;Artificial Feeding;Artificial Intelligence;Artificial Membranes;Attenuated;Basic Science;beta pleated sheet;Biology;Birds;Bite;Black-legged Tick;Blood;Borrelia;Borrelia burgdorferi;California;Cell Culture System;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;cellular imaging;Cessation of life;Chiroptera;chronic infection;Classification;Codon Nucleotides;Collaborations;Data;Development;Disease;Dissection;Dissociation;Domestic Fowls;Entomology;Experimental Models;experimental study;Family;feeding;Female;Flavivirus;Flavivirus Infections;Gene Expression;Genes;genetic approach;Genetic Transcription;Genome;Genomics;Geography;Goals;Growth;Histologic;Human;human pathogen;Image;Imaging Techniques;Immunology;improved;in silico;In Situ Hybridization;Indigenous;Individual;Infection;Investigation;Island;Laboratories;Langat virus;Laridae;Leg;Libraries;Lyme Disease;male;Mammals;member;Methods;Microbe;microbiome;Midgut;Modeling;Modification;Molecular;Molecular Biology;Molting;Montana;Mus;North Dakota;novel;Nymph;Organ;Organ Culture Techniques;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phylogenetic Analysis;Plasmid Cloning Vector;Powassan virus;Preparation;Procedures;Process;programs;Protein Analysis;protein structure prediction;Proteins;Proteomics;Protocols documentation;Public Health;Publications;Reaction;Recording of previous events;Relapsing Fever;Reporting;reproductive;Research;reverse genetics;Risk;RNA;RNA Viruses;Rodent Model;Salivary Glands;Sea Cucumbers;Sequence Alignment;single cell analysis;single cell technology;Specimen;Structure;System;Tail;Testing;tick feeding;tick-borne;Tick-Borne Diseases;tick-borne flavivirus;tick-borne virus;Ticks;Tissues;Transcript;transcriptome;transmission process;Trinidad;Universities;vector;vector transmission;vector-borne;Viral;Viral Proteins;virology;Virus;Virus Diseases;virus identification;Virus Replication;Work

PROJECT_TITLE: Pathogenesis of Tick-Borne Flavivirus Infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vector-Borne Diseases

PI_NAMEs: BARILLAS-MURY, CAROLINA  (contact)

PROJECT_TERMS: Acceleration;Adult;Aedes;Affect;Affinity;African;Anopheles gambiae;Anopheles Genus;antiviral immunity;Apoptosis;Apoptotic;Asia;Asian;Binding;Caspase;cell injury;cell type;Cells;Code;Complement Activation;Complex;Computer software;Culicidae;Cytolysis;defense response;Dengue Infection;Dengue Virus;disease transmission;Double-Stranded RNA;Drosophila genus;env Gene Products;Epithelial Cells;Epithelium;Falciparum Malaria;Female;Genes;genetic analysis;Genome;Glycoproteins;Goals;Gorilla gorilla;granulocyte;gut microbiota;Haplotypes;Heat shock proteins;Hemocytes;Heterozygote;Hsc70 protein;Human;Image;Immobilization;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunoglobulin binding proteins;Immunologic Memory;Individual;Infection;ING1 gene;Injections;Invaded;Kinetics;Knock-out;Malaria;malaria infection;malaria transmission;Maps;Mass Spectrum Analysis;Mediating;Membrane Proteins;microvesicles;Midgut;Molecular;mRNA Expression;nitration;novel;Oocysts;Orthologous Gene;Papua New Guinea;Parasites;pathogen;Pathway interactions;Phagocytosis;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Population;precursor cell;Prevalence;prevent;progenitor;Proliferating;protein E;Protein Isoforms;Proteins;receptor;Receptor Gene;Recombinants;response;RNA;RNA Splicing;Role;Serotyping;single cell analysis;Site;stem cell proliferation;stem cells;Surface;Surface Plasmon Resonance;Time;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Trypsin;Untranslated RNA;vector;vesicular release;Virion

PROJECT_TITLE: Mosquito Immune Responses and Malaria  Transmission


NIH_SPENDING_CATS: Autoimmune Disease;Genetics

PI_NAMEs: SHEVACH, ETHAN  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Age;antagonist;Antibodies;Antibody Specificity;Antigen Targeting;Area;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocyte Epitopes;beta catenin;Birth;CCR6 gene;CD4 Positive T Lymphocytes;CD44 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Collaborations;congenic;Cytoplasmic Granules;cytotoxic;deprivation;Development;directed differentiation;Disease;disease phenotype;Effector Cell;Equilibrium;exhaust;Exhibits;Family;Family member;Fatty Liver;Flow Cytometry;FOXP3 gene;Frequencies;G-Protein-Coupled Receptors;Gene Expression;Gene Family;Goals;HDAC1 gene;Hypergammaglobulinemia;IL2RA gene;immune activation;Immunofluorescence Microscopy;Immunoprecipitation;In Vitro;in vivo;Inbred BALB C Mice;Infiltration;Inflammatory;Insulin Resistance;Integrins;Interleukin-2;Knock-out;Knockout Mice;Libraries;Life;Lipodystrophy;Lymphocytic Infiltrate;Maintenance;Mediating;member;Memory;migration;Molecular;Monoclonal Antibodies;Mus;NFAT Pathway;offspring;Organ;Parabiosis;Pathogenesis;Pathway interactions;perilipin;Peripheral;Phage Display;Phage ImmunoPrecipitation Sequencing;Phenotype;Play;Population;prevent;Process;Property;Proteins;Proteome;Regulation;Regulatory T-Lymphocyte;response;Role;Self Tolerance;Serum;Signal Pathway;single-cell RNA sequencing;Site;Splenocyte;Structure of germinal center of lymph node;Structure of thymic medulla;systemic autoimmunity;T memory cell;T-Cell Immunologic Specificity;T-Lymphocyte;T-Lymphocyte Epitopes;T-Lymphocyte Subsets;Technology;Thymus Gland;transcription factor;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Tumor Necrosis Factor Ligand Superfamily Member 6;Wild Type Mouse

PROJECT_TITLE: Studies of the Function of Naturally Occurring and Adaptive T Regulatory Cells


PI_NAMEs: GERMAIN, RONALD N (contact)

PROJECT_TERMS: Animals;Antigens;assay development;Autoimmune;Bacterial Infections;Behavior;Biochemical;biochemical model;Biological Models;CD8B1 gene;Cell Communication;Cell Death;Cell division;Cells;Cluster Analysis;Collaborations;Complex;Computer Models;Data;Development;Disease;drug development;Environment;Event;experience;Experimental Animal Model;Exposure to;Gene Expression;Genetic Transcription;Goals;Hour;Human;human model;Immune;Immune response;Immune system;immune system function;Immunological Models;Immunology;In Situ;Individual;Infection;Infectious Agent;Inflammatory;insight;Laboratories;Ligands;Link;Lymphoid Cell;Macrophage;Malignant - descriptor;Measurement;member;Methods;Modeling;Myeloid Cells;Nuclear;nuclear factors of activated T-cells;Organism;pathogen;Pathogenicity;Pathway interactions;Peptide/MHC Complex;Phenotype;predictive modeling;Process;programs;Proteins;Reagent;real-time images;Real-Time Systems;receptor expression;Regulatory Pathway;Research;response;Role;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stains;Stimulus;success;System;Systems Biology;T-Lymphocyte;Tail;Time;Tissue imaging;Tissues;tool;vaccine development;Vaccines;Variant;Virus Diseases

PROJECT_TITLE: Immunology Team Contributions to the LSB


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: LUSSO, PAOLO  (contact)

PROJECT_TERMS: Affect;Anatomy;antagonist;antimicrobial;Blood Cells;cancer therapy;CCL3 gene;CCL4 gene;Cells;chemokine;Chemotherapy-Oncologic Procedure;Collaborations;Communicable Diseases;Complex;COVID-19;cytokine;Disease;experimental study;Face;Gene Expression;Genes;HIV;HIV-1;HIV/AIDS;Homeostasis;Homing;Human;IL7 gene;Immune;immune function;immune modulating agents;Immune response;Immune system;Immunologics;immunoregulation;In Vitro;in vivo;Inflammatory;Integrins;interest;Interferon alpha;Interferon Type II;Intervention;Intestines;Invaded;Knowledge;Laboratories;Lymphocyte;Lymphopenia;Macaca;Mediating;Medical;Microbe;microorganism;Modeling;monocyte;novel;P-selectin ligand protein;pathogen;Pathogenesis;pathogenic microbe;Patients;Physiological;Prevention;Production;programs;RANTES;Readiness;receptor;reconstitution;recruit;Research;response;Rest;Role;Signal Transduction;Stimulant;T-Cell Activation;T-Lymphocyte;TNF gene;Toll-like receptors;transcriptome sequencing;Virion;Work

PROJECT_TITLE: Role of IL-7 in Immune Defense against HIV-1 and Other Infectious Pathogens


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: HACKSTADT, TED  (contact)

PROJECT_TERMS: Ablation;Actins;Address;Affect;Amblyomma;Animal Model;Antibodies;Apoptosis;Arizona;Attenuated;Awareness;Bacteria;Biological Models;Biology;Bite;Brazil;Cavia;Cell Culture Techniques;Cells;Characteristics;Clinical;clinically relevant;comparative genomics;Cytolysis;Cytoplasm;Data;Dermal;design;Disease;Disease Outbreaks;Disease Progression;emerging pathogen;Etiology;Exanthema;experimental study;Extravasation;Fever;Future;Genes;Genetic;genetic technology;Genome;Genomics;Goals;Golgi Apparatus;Growth;Human;human disease;IFNAR2 gene;Immunologics;improved;in vivo;Infection;Interferon-beta;Interferons;Iowa;Knock-out;Laboratory Animals;Length;Life;Life Style;Liquid substance;member;Membrane;Mexico;Microfilaments;Molecular;monolayer;Motility;mutant;N-terminal;Nature;Organism;Outcome;overexpression;Pathogenesis;Pathogenicity;Peptide Hydrolases;periplasm;Phenotype;Polymers;Process;Production;Productivity;prototype;Publishing;Recombinants;reconstitution;Recording of previous events;Regulation;response;Rhipicephalus sanguineus;Rickettsia;Rickettsia Infections;Rickettsia rickettsii;Rocky Mountain Spotted Fever;SCA2 protein;Serial Passage;Severities;spotted fever;Stains;Surface;Surface Antigens;System;Tail;tick-borne;Ticks;trafficking;transmission process;Variant;Vascular Endothelial Cell;Vascular Permeabilities;vector tick;Vero Cells;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Biology of Rickettsia