NIH_SPENDING_CATS: Aging;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Aging is an overlooked risk factor for chronic pain for which we have identified a novel potential target: senescent dorsal root ganglion (DRG) neurons induced by age and injury. In this proposal, we will validate subpopulations of senescent DRG neurons that contribute to inflammation and neuronal hyperexcitability in mouse models of chronic pain. We further extend these analyses to aged human post-mortem DRG tissues to strengthen the evidence that our target will be robust in translation, thereby opening a new therapeutic avenue for the treatment of pain.

PI_NAMEs: TAWFIK, VIVIANNE L (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: activating transcription factor 3;Adult;Afferent Neurons;Age;age effect;age related;age-related disease;aged;Aging;allodynia;Animal Model;animal old age;Animals;Apoptosis;Autopsy;Basic Science;Behavioral;Cell Aging;Cell secretion;Cells;Cellular Stress;central pain;chemokine;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;clinically relevant;comorbidity;cytokine;Data;Development;Dissociation;Electrophysiology (science);experimental study;Female;Future;ganglion cell;Genes;Genetic;Goals;Heterogeneity;Histologic;Homeostasis;Human;human old age (65+);IL6 gene;Immune system;improved;Induced Neurons;Inflammation;Inflammatory;Injury;Interleukin-1 beta;Investigation;Ion Channel;Knowledge;Laboratories;male;mechanical allodynia;Mediator;Medical;Medicine;Methods;mouse model;Mus;Nature;nerve injury;neuronal cell body;neuronal excitability;Neuronal Injury;Neurons;normal aging;novel;novel therapeutics;old mice;older adult;Orthopedics;Pain;pain behavior;Pain management;Pain Measurement;pain model;Peptide Hydrolases;Peripheral;Peripheral nerve injury;Persistent pain;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Physicians;Population;pre-clinical;Predisposition;Prevalence;Production;Research;Resistance;Risk Factors;Rodent;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sensory;sex;side effect;single nucleus RNA-sequencing;Sorting;Source;spared nerve;Spinal Ganglia;Surgical incisions;Therapeutic;therapeutic development;tissue injury;Tissues;tool;translational potential;Translations;Trauma;Validation;young adult

PROJECT_TITLE: Validation of neuronal senescence as a target for chronic pain in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Z (55)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Iron is integral to vital physiological functions in humans, and maintaining proper iron levels is critical due to the severe health problems that can arise from imbalances. This project will investigate the metalloproteins associated with human iron homeostasis, employing structural and spectroscopic methods to deepen understanding of their molecular mechanisms. The insights obtained could facilitate the development of innovative therapeutic approaches for various diseases, including cancer and neurodegenerative conditions.

PI_NAMEs: TIAN, SHILIANG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: abeta accumulation;Address;Alzheimer's Disease;Amyloid beta-Protein Precursor;Apoptosis;Biological;Biological Process;Brain;cancer therapy;Cells;Ceruloplasmin;Defense Mechanisms;Development;Disease;DNA biosynthesis;DNA Repair;Elements;Equilibrium;extracellular;Generations;Genes;Health;Hippocampus;Homeostasis;Human;Human body;Immune response;immunoregulation;innovation;insight;interdisciplinary approach;Iron;Iron-Regulatory Proteins;Label;Malignant Neoplasms;Membrane;Messenger RNA;metal transporting protein 1;Metalloproteins;Metals;Methods;Mitochondria;Molecular;Motor Cortex;Myelin;Nerve Degeneration;Neurodegenerative Disorders;neurotransmitter metabolism;Oxidation-Reduction;oxygen transport;Parietal Lobe;Pathologic;Peptides;Physiological;Play;posttranscriptional;Procedures;Process;Production;Proteins;Regulation;Research;Response Elements;Role;secretase;Senile Plaques;Structure;System;Therapeutic;transcriptome;Translations;Untranslated Regions;Work

PROJECT_TITLE: Deciphering the Structures and Mechanisms of Metalloproteins Involved in Human Iron Homeostasis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Heterogeneity in attention-deficit/hyperactivity disorder (ADHD) diagnoses and among existing genomic studies poses a major challenge that has left much of the underlying genetic etiology of well-defined primary ADHD (i.e., ADHD without co-occurring intellectual disability or autism spectrum disorder) unknown. The proposed study will be the first to assess the genetic architecture of ADHD through the development a large cohort of children with primary ADHD and their families using consistent, precise, and comprehensive diagnostic criteria. Findings from our family-based study will improve our understanding of genomic architecture of ADHD, provide important genetic diagnoses for families, and inform future genomic and neurobiological functional studies that are likely to impact clinical management for families with ADHD.

PI_NAMEs: ARNETT, ANNE BERNARD;DOAN, RYAN NEIL (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Affect;All of Us Research Program;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;biobank;Boston;Brain;Candidate Disease Gene;case control;cell type;Child;Classification;Clinical;Clinical Management;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;comorbidity;Consensus;Data;Databases;de novo mutation;Development;Diagnosis;diagnostic criteria;disease-causing mutation;DNA Sequence Alteration;DNA sequencing;Etiology;Evaluation;Exclusion Criteria;exome sequencing;Family;family management;Family member;Future;gene discovery;gene network;Generations;Genes;Genetic;genetic architecture;Genetic Databases;Genetic Diseases;genetic disorder diagnosis;Genetic Predisposition to Disease;Genetic study;genetic variant;genome wide association study;genome-wide;genomic data;Genomics;Goals;Heritability;Heterogeneity;human induced pluripotent stem cells;improved;In Vitro;Individual;induced pluripotent stem cell;Inheritance Patterns;Inherited;innovation;insight;Intellectual functioning disability;International;Investigation;Left;Medical Genetics;Medicine;meetings;Methods;Minority;Modeling;Molecular;mRNA sequencing;Mutation;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropsychology;novel;Other Genetics;Participant;Pathogenesis;Pathogenicity;Patient Self-Report;Patients;Pattern;Pediatric Hospitals;Persons;Phenotype;proband;rare variant;Recording of previous events;recruit;repository;research clinical testing;Resources;Risk;Role;Sampling;School-Age Population;screening;segregation;Siblings;Site;SNP genotyping;Source;Standardization;Symptoms;Syndrome;Testing;treatment response;United States National Institutes of Health;Validation;Variant;variant of interest;variant of unknown significance

PROJECT_TITLE: Advancing Understanding of Genomic Mechanisms for Primary ADHD in Families

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Imaging specific biological processes in cells is a fundamental capability for researchers and clinicians in the disease diagnosis and monitoring of therapeutic cells. This proposal builds on the recently introduced ultrasound- based reporter genes, which may enable one to use ultrasound to follow the state of engineered cells in human patients. Specifically, the project aims to develop the next-generation genetic design of these reporters to enable order-of-magnitude increase of the brightness of their ultrasound signals.

PI_NAMEs: LU, GEORGE J (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Next-generation design of acoustic reporter genes with optimal assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

PHR: We will test the limits of our recently developed method of NMR-guided evolution and apply it 1) to proteins that cannot be easily characterized using NMR spectroscopy; 2) to design of highly active metalloenzymes for practically useful reactions and 3) to devlop metalloproteins with high metal affinities. I will also develop new approaches to osteoarthritis treatment using smart, stimuli-responsive, self-healing biocompatible antimicrobial hydrpogels.

PI_NAMEs: MAKHLYNETS, OLGA  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Metalloproteins: evolution, catalysis and material design


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PROVO

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: The proposed research is relevant to public health because it further develops new technology in protein crys- tallography and high-resolution structure determination. Development of such technology will accelerate the study of molecular disease mechanisms and development of more effective disease treatments. The proposed research is relevant to components of the NIH NIGMS’s mission that pertain to 1) increasing our understanding of biological processes, 2) laying the foundation for advances in disease diagnosis, treatment, and prevention, and 3) supporting the training of the next generation of scientists, enhancing the diversity of the scientific work- force.

PI_NAMEs: MOODY, JAMES DANIEL (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Address;Biological Process;Biological Products;Biological Response Modifier Therapy;Biomedical Engineering;Biotechnology;Carrier Proteins;Chimeric Proteins;Communities;cost;Crystallization;Crystallography;Data Analyses;Data Collection;Development;Disease;disease diagnosis;Drug Targeting;effective therapy;Experimental Designs;Foundations;Goals;graduate student;Health Care Costs;human disease;improved;Industrialization;Industry;interest;International;Manuscripts;meetings;Methods;Mission;Molecular Chaperones;Molecular Disease;National Institute of General Medical Sciences;new technology;next generation;novel;Pharmaceutical Preparations;Polymers;Preparation;Prevention;programs;Protein Engineering;protein structure;Proteins;Public Health;Reagent;Research;Resolution;Resources;Scientific Inquiry;Scientist;small molecule;structural biology;Structure;symptom management;Technology;Time;tool;Training Support;undergraduate student;United States National Institutes of Health;Vision;X ray diffraction analysis

PROJECT_TITLE: Expanding the capabilities and usage of the TELSAM protein crystallization chaperone

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: MADISON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Bacterial infection continues to be a major global health threat that has been exacerbated by the emergence and unabated spread of antimicrobial-resistance. The goal of this proposal is to develop a new rapid identification and antimicrobial susceptibility testing platform for clinical isolates utilizing an exclusive liquid repellency-based under- oil open microfluidic system to ensure 1) prompt coverage of infecting organisms and 2) prevention of overuse of broad-spectrum antimicrobials.

PI_NAMEs: BEEBE, DAVID J;ROSE, WARREN E (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Abscess;Adoption;Anaerobic Bacteria;Anti-microbial susceptibility;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Infections;bacterial resistance;biobank;Biomedical Engineering;Blood;Cause of Death;Cells;Centrifugation;Cessation of life;Clinical;Clinical Microbiology;Communities;Consumption;Cytolysis;deep learning;deep learning algorithm;Detection;Development;Ensure;Event;Fluorescence;global health;Goals;Growth;Hospitals;Hour;human pathogen;Image;imaging modality;improved;Individual;Infection;Intermediate resistance;Label;Laboratories;Liquid substance;live cell imaging;Methods;Microfluidics;Molecular;multidisciplinary;mutant;Nature;next generation;Oils;Organism;Outcome;Phenotype;Population;Preparation;prevent;Prevention;Recovery;Reporting;Resistance;resistance gene;Resolution;Sampling;Scientist;screening;Selection Bias;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sputum;Surface;System;Technology;Testing;Time;United States;Urine;Whole Blood;whole blood bacteria

PROJECT_TITLE: Exclusive liquid repellency enables next-generation phenotypic antimicrobial susceptibility testing

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Animal models of oxygen-induced retinopathy (OIR) have provided the foundation for our understanding of molecular responses to ischemic injury in the retina and the pathophysiology of ischemic retinal vascular diseases such as diabetic retinopathy and retinopathy of prematurity. Visible-light optical coherence tomography (vis-OCT) is a newer imaging technology that provides both retinal structure and blood vessel patterns and direct measures of retinal vascular oxygen levels in animal models of disease. In this study, we will develop a new wide-field (WF)-vis-OCT to establish normative data for longitudinal changes in tissue oxygenation and blood flow in the rat OIR model, and in vivo assessment of nonperfusion and neovascularization, with comparison to the traditional ex vivo OIR biomarkers.

PI_NAMEs: CAMPBELL, JOHN PETER;JIA, YALI  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;angiogenesis;Angiography;Animal Disease Models;Animal Model;Animals;Area;Automobile Driving;Biological Markers;Blindness;Blood capillaries;Blood flow;Blood Vessels;Childhood;Computer software;Control Animal;Custom;Data;deep learning;design;Detection;Development;Devices;Diabetic Retinopathy;Disease;Ensure;Environment;Euclidean Space;Evaluation;Evolution;Eye;Foundations;Functional disorder;Histologic;Hyperoxia;Hypoxia;Image;image guided;imaging approach;imaging probe;Imaging technology;improved;In Vitro;in vivo;innovation;insight;Intervention;Investigation;Ischemia;ischemic injury;lens;Longitudinal Studies;Measurement;Measures;Membrane;meter;Methodology;Microfluidic Microchips;Modeling;Molecular;neovascular;neovascularization;novel;novel marker;novel therapeutics;operation;Optical Coherence Tomography;Optics;Oxygen;Oxygen saturation measurement;Pathologic;Pathology;Pattern;Performance;Peripheral;Phase;Physiology;pre-clinical;Pre-Clinical Model;Rattus;real-time images;Research;Research Design;Resolution;response;Retina;retina blood vessel structure;retina circulation;Retinal Diseases;retinal imaging;retinal ischemia;Retinopathy of Prematurity;revascularization;Scanning;Study Section;System;Therapeutic;Therapeutic Intervention;Time;tissue oxygenation;Tissues;Training;Vascular Diseases;Vascular Endothelial Growth Factors;Velocimetries;Venous;Visible Radiation;Visit;Work

PROJECT_TITLE: Advancing visible-light OCT in oxygen-induced retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Small organic molecules and nucleic acid polymers are essential to developing next-generation therapeutics. Existing small molecules that can target RNA are limited by their selectivity and efficacy, and nucleic acid therapies are challenged by their off-target effects and suboptimal biostabilities. In this MIRA application, we propose to address these limitations and challenges by developing small molecule-based RNA degraders with high selectivity and efficacy, and biostable and programmable nucleic acid polymers with advanced therapeutic capabilities.

PI_NAMEs: IZGU, ENVER C (contact)

PROJECT_TERMS: Address;Agonist;Biochemical;Biotechnology;catalyst;Catalytic RNA;Cells;clinical application;Collaborations;design;Development;Dinucleoside Phosphates;Disease;diversity and inclusion;drug development;Engineering;Exhibits;Face;Foundations;G-Quartets;Goals;Inflammation Mediators;Institution;Kinetics;Ligands;Malignant Neoplasms;Molecular;novel;novel therapeutics;nucleic acid-based therapeutics;Nucleic Acids;Organic Chemistry;Pathway interactions;Periodicity;phosphoramidate;Polymers;precision medicine;programs;Research;Research Project Grants;RNA;RNA Degradation;small molecule;Stimulator of Interferon Genes;Therapeutic;therapy development;Vertebral column

PROJECT_TITLE: SMALL-MOLECULE AND NUCLEIC ACID ENGINEERING TOWARD MOLECULAR DESIGNS OF THERAPEUTIC POTENTIAL


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative This is the first effectiveness test of a highly portable home-based exercise intervention after an implantable cardioverter defibrillator (ICD), delivered using the expertise of cardiac rehabilitation staff using technology monitoring (Step Watch, Polar HR Monitor) of intervention progress and outcomes. Evidence for intervention effectiveness and implementation feasibility will lay a strong foundation that provides patients and clinicians the tools to initiate and monitor exercise for a broad spectrum of ICD recipients, and identifies protocols and training that will promote high fidelity implementation in subsequent trials.

PI_NAMEs: DOUGHERTY, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Adherence;Adoption;Aerobic Exercise;American;Anxiety;Area;Arrhythmia;Behavior;behavior test;Behavior Therapy;Behavioral;Behavioral Model;Cardiac;Cardiac rehabilitation;Caring;Cessation of life;Characteristics;Clinical;Clinical effectiveness;clinical practice;Clinical Practice Guideline;Clinical Research;clinical research site;cost;cost effectiveness;County;Data;design;Diagnosis;Disease;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness study;effectiveness testing;Elements;Eligibility Determination;Emotional;Equity;Evaluation;Exercise;exercise intensity;exercise intervention;exercise prescription;exercise program;experience;Familiarity;Financial cost;Foundations;Fright;future implementation;Gait speed;Goals;Health;health care delivery;health related quality of life;Healthcare Systems;Heart Arrest;Heart failure;Heart Rate;heart rate monitor;high risk;Home;hospital readmission;Hospitalization;Household;Hybrids;Implant;Implantable Defibrillators;implementation cost;implementation fidelity;implementation outcomes;implementation research;implementation strategy;improved;Individual;Institution;Intervention;Intervention Studies;knowledge integration;Maintenance;Measures;Mental Depression;Methods;Mind;Mission;Modeling;Monitor;mortality;National Heart, Lung, and Blood Institute;Outcome;Outpatients;Participant;participant retention;patient engagement;Patient Participation Rates;Patients;Persons;PhenX Toolkit;Physical activity;Physical Function;Pilot Projects;Population;portability;Practice Guidelines;pragmatic study;prevent;primary outcome;Protocols documentation;Public Health;Qualifying;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research Design;Resources;response;safe patient;Safety;Sampling;satisfaction;Self Efficacy;Sex Behavior;Shock;Site;social;social health determinants;Strenuous Exercise;Stress;Technology;telephone delivery;Testing;tool;Training;treatment as usual;United States National Institutes of Health;Ventricular Arrhythmia;Visit;Walking;wearable device;Work

PROJECT_TITLE: Clinical Effectiveness of Exercise After an Implantable Cardioverter Defibrillator (ICD)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Gut microbial ene-reductases mediate critical biotransformations impacting both microbial and host physiology. Stool metabolomics data implicates the existence of numerous unidentified ene-reductases, constituting a gap in our understanding of gut microbial metabolism. The proposed research will develop a platform combining microbiology, biochemistry, and bioinformatics to systematically identify novel gut microbial ene-reductases, elucidating their genetic basis, their impact on microbial physiology, and illuminating ways they may interact with host physiology.

PI_NAMEs: HALL, ANDREW BRANTLEY (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Enzymatic Determinants of Gut Microbial Metabolic Biotransformations


ADMINISTERING_IC: DC

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Lung;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative Vocalization is used in many species for social and emotional communications. Here we will not only identify the hitherto unknown cell types and circuits that trigger emotional cries but also reveal precise neurons and mechanisms underlying vocal-respiration coordination. Our study will provide foundational knowledge for finding potential treatment targets for disorders of motor speech productions, and other diseases involving vocal cord dysfunction such as dysphagia.

PI_NAMEs: WANG, FAN  (contact);YAO, SHENQIN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Ablation;adduct;Air;Air Pressure;Atlases;Automobile Driving;Brain;Brain Stem;Breathing;Cell Nucleus;cell type;Cells;cellular targeting;Communication;Contracts;Coughing;Coupling;Courtship;Crying;Cues;Deglutition;Deglutition Disorders;Disease;Dissection;Dysphonia;Electrophysiology (science);Elements;Emotional;Ensure;Exhalation;experimental study;expiration;Fiber;Foundations;Functional disorder;Future;Health;Hypothalamic structure;in vivo;Inhibitory Synapse;Investigation;Knowledge;Label;Larynx;Lung;Mammals;Maps;Mechanics;Methods;midbrain central gray substance;Molecular;molecular marker;Monitor;Motor;Motor Cortex;motor disorder;Motor Neurons;Movement;Mus;neuromechanism;Neurons;Nucleus solitarius;optogenetics;Pain;Pathway interactions;Phase;Phonation;Photometry;Physiological;Population;presynaptic;presynaptic neurons;Production;Rabies;Rabies virus;Research Proposals;Respiration;respiratory;response;Role;Shapes;social;Social Interaction;sound;Speech;Stress;success;Synapses;Testing;Toxic effect;transcriptome sequencing;transcriptomics;Ultrasonics;vibration;Viral;Virus;vocal control;vocal cord;vocalization;Voice

PROJECT_TITLE: The brainstem vocal control circuits

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Precision medicine approaches are urgently needed to improve self-management support for adults with type 2 diabetes. Our innovative validated typology of diabetes-specific family functioning will be applied to get the right intervention to the right person at the right time. In a randomized controlled trial, we will evaluate the benefits of an adaptive intervention - tailored over time using typology assessments and delivered via basic mobile phone technology - on participants' hemoglobin A1c, diabetes distress and global well-being.

PI_NAMEs: MAYBERRY, LINDSAY S. (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: adaptive intervention;Adult;Affect;American;Behavior;behavior change;Behavior Therapy;Behavioral;Caring;Cellular Phone;Classification;Clinical;Data;depressive symptoms;design;diabetes distress;Diabetes Mellitus;diabetes self-management;Dimensions;Disease;Enrollment;Ethnic Origin;Evidence based intervention;experience;Family;Family member;family structure;Friends;Glycosylated hemoglobin A;Goals;Heterogeneity;improved;improved outcome;Individual;Individual Differences;Infrastructure;innovation;Intervention;intervention effect;Learning;Literature;Measurement;Mediating;medication compliance;meetings;Methods;Monitor;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Participant;Patients;Personal Satisfaction;Persons;post intervention;precision medicine;Prevalence;Primary Care;psychosocial wellbeing;racial diversity;racial minority;Randomized, Controlled Trials;Recommendation;Research;Right to Treatments;Sampling;Self Care;Self Efficacy;Self Management;skills;social;Social Environment;Source;Strategic Planning;Surveys;System;systematic review;Technology;telephone coaching;texting support;Thinking;Time;time use;tool;treatment as usual;treatment effect;Typology;United States National Institutes of Health;Variant;Well in self

PROJECT_TITLE: Tailoring Diabetes Support to Social Contexts for Adults Living with Type 2 Diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The proposed INCLUDE supplement aligns with INCLUDE’s research plan Component 3 priority area, as well as NIDCD’s vision to improve the lives of people with communication disorders, by informing language and communication interventions for young children with Down syndrome (DS). Findings from the proposed supplement will inform caregiver-mediated interventions by providing empirical evidence for specific clinical recommendations on adult linguistic simplification, thus contributing to improved long-term outcomes in children with DS.

PI_NAMEs: VENKER, COURTNEY E (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Affect;Age;Area;autistic children;Behavioral;Birth;Canis familiaris;Caregivers;Characteristics;Child;Child Language;Clinical;Clinical Management;clinical practice;Clinical Trials;Cognitive;cognitive ability;cognitive skill;Communication;Communication impairment;Cues;Diagnosis;Down's Syndrome;Early Intervention;Educational process of instructing;evidence base;evidence based guidelines;expectation;experience;falls;Impairment;improved;Individual;innovation;Intellectual functioning disability;Intervention;Language;language comprehension;Language Development;Language Disorders;language processing;Learning;lexical;Life;Light;Linguistics;literacy;Mediating;mental age;Methodology;Mothers;National Institute on Deafness and Other Communication Disorders;non-verbal;Outcome;Parents;Participant;Pathologist;Performance;Persons;Population;prevent;Process;Quality of life;Recommendation;Research;Sampling;Short-Term Memory;skills;Speech;Standardization;syntax;Testing;theories;Time;Vision;Vocabulary;word learning;Work

PROJECT_TITLE: How Single-Word and Telegraphic Simplification Affects Language Processing and Word Learning in Young Children with Down Syndrome


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Fragile X syndrome is the most common genetic cause of autism and symptoms of autism typically emerge during early infancy, a time when the neocortex undergoes extensive synaptogenesis and synapse elimination, so-called transient connectivity. Using multi-facetted approaches, including electrophysiology, single-cell transcriptomics and CRISPR strategy, we will investigate the role of sensory and neuromodulatory transient connections in the development of healthy and FXS cortical maturation. This work will provide novel insights into the role of transient connectivity on sensory and cognitive experience-dependent cortical maturation and lay the foundations for exploring approaches targeting the onset of circuit dysfunctions in FXS.

PI_NAMEs: POUCHELON, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: 3 year old;Acetylcholine;Address;Adult;Age Months;Anatomy;autism spectrum disorder;autism symptoms;autistic children;Automobile Driving;Behavior Therapy;Birth;Brain;Candidate Disease Gene;cell type;Cells;Child;cholinergic;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;combinatorial;critical period;Cues;D Cells;Data;Development;Diagnosis;early onset disorder;effective therapy;Electrophysiology (science);Environment;Equilibrium;experience;Foundations;Fragile X Syndrome;Functional disorder;Future;Gene Expression Regulation;Genes;Genetic;genetic approach;Hypersensitivity;Impairment;infancy;Infant;inhibitory neuron;insight;interdisciplinary approach;Interneurons;Knowledge;Measures;Modeling;Molecular;molecular marker;mouse genetics;mouse model;Mus;Muscarinic Acetylcholine Receptor;Neocortex;neuronal circuitry;Neurons;Neuropeptides;neuroregulation;novel;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;postnatal;receptor;Research;Role;Sensory;Signal Transduction;Slice;Somatostatin;Synapses;synaptic pruning;synaptogenesis;synergism;Testing;therapeutic development;Time;tool;transcriptomics;Viral;virtual;Work

PROJECT_TITLE: Postnatal transient connectivity in brain development and implications in fragile x syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Patient Safety;Pediatric;Prevention;Telehealth

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The Emergency Medical Services (EMS) 2050 Agenda for Future Systems envisions integration of telehealth tools to make prehospital care safer and more effective, so we need to demonstrate whether this technology can improve patient safety. This study tests the efficacy of using low-cost, mobile technology for infants and children who need life-saving care outside hospitals in two ways—(1) using pediatric experts in hospitals to support EMS clinicians in ambulances by video, and (2) reviewing video recorded EMS encounters as a method to measure care safety and quality. If this strategy produces measurably safer care with real EMS- physician teams in realistic simulated environments, it will provide the scientific basis for EMS systems to adopt and use telehealth tools to improve care for children.

PI_NAMEs: BOYLE, TEHNAZ PARAKH (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;Adverse effects;Agreement;Ambulances;Applied Research;arm;Benefits and Risks;Blinded;Caring;Cessation of life;Child;Child Care;Childhood;Clinical;clinical encounter;clinical implementation;cohort;Collaborations;Communication;Community Services;Consultations;cost;Critical Illness;Critically ill children;Crossover Design;Data Set;Decision Making;design;Detection;effectiveness trial;efficacy research;efficacy testing;Electronics;Emergency Care;Emergency Department Physician;Emergency medical service;Enrollment;Environment;Equipoise;Event;evidence base;Frequencies;Funding;Future;Goals;Harm Reduction;Health Services Research;high risk;high risk population;Hospital safety;Hospitals;improved;improved outcome;In Situ;Infant;Infrastructure;innovation;Interdisciplinary Study;Intervention;intervention effect;Investments;Life;Measurable;Measures;Medical Records;Mentored Patient-Oriented Research Career Development Award;Methods;mobile computing;Modeling;models and simulation;multidisciplinary;Outcome;Outcome Assessment;Outcome Measure;Paper;Paramedical Personnel;patient health information;patient safety;Patients;pediatric emergency;Physicians;Pre-hospital setting;Pre-hospitalization care;Prevalence;prevent;primary outcome;Process;Protocols documentation;prototype;Radio;Randomized;randomized trial;Randomized, Controlled Trials;Records;Reporting;Research;Research Infrastructure;Resuscitation;resuscitative care;Retinal blind spot;Risk Reduction;Safety;safety study;Service delivery model;service providers;simulation;Single-Blind Study;Standardization;Surveillance Methods;System;Techniques;Technology;teleconsultation;telehealth;Telephone;Testing;Time;tool;treatment as usual;Treatment Efficacy;Variant;Video Recording

PROJECT_TITLE: Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Project Narrative The influence of tissue mechanics on cell behavior has been widely acknowledged, especially in the contexts of wound healing, disease advancement, and regenerative medicine, however, there is a critical shortage of materials that can effectively elucidate the intricate relationship between tissue mechanics and cellular responses. In this proposal, our primary goal is to enhance the applicability of hydrogel biomaterials by harnessing clinically approved plasmid deoxyribonucleic acid (DNA) to create materials that emulate the properties of living tissues. This approach will allow us to integrate unique structural and functional attributes inspired by the versatile and dynamic characteristics of DNA enabling fundamental understanding of cell- environment homeostasis research and facilitating transition into clinical applications.

PI_NAMEs: OLDENHUIS, NATHAN JOHN (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Biocompatible Materials;Biological Process;biological systems;Biology;biomaterial compatibility;biophysical analysis;Biosensing Techniques;cell behavior;Cell Culture Techniques;Cells;Cellular biology;cGMP production;Characteristics;Clinical;clinical application;clinical efficacy;clinical translation;Complex;cost;cytotoxicity;Disease;DNA;Drug Delivery Systems;ds-DNA;Elasticity;Encapsulated;Environment;Exhibits;Extracellular Matrix;Goals;Growth Factor;healing;Homeostasis;Hydrogels;insight;large scale production;mechanical properties;Mechanics;mimetics;Nutrient;Onset of illness;Plasmids;programs;Property;Proteins;Regenerative Medicine;Research;response;Role;scaffold;Time;Tissue Engineering;Tissues;Vaccines;viscoelasticity;wound healing

PROJECT_TITLE: Using DNA hydrogels to mimic, exploit, and fundamentally investigate extracellular matrices


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The long-term goal of this research project is to understand the neural mechanisms underlying the control of behavior in two domains: self-control (motivation) and response inhibition (motor). We will record neurons from 5 different areas in the prefrontal cortex, while NHPs engage in two oculomotor decision tasks that require them to exert self-control and motor-control, respectively. This will allow us to determine the functional overlap and separation between these control systems.

PI_NAMEs: STUPHORN, VEIT  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adaptive Behaviors;Althaea;Anatomy;Area;Attention deficit hyperactivity disorder;Behavior;Behavior Control;Behavioral;behavioral outcome;Brain;Data;dieting;Disease;Eating;Eating Disorders;executive function;experimental study;Failure;frontal eye fields;frontal lobe;Goals;Grant;Human;Informal Social Control;innovation;Interruption;Lesion;Light;Monkeys;Motivation;Motor;motor control;neural;neural circuit;neuroimaging;neuromechanism;neuronal circuitry;Neurons;novel;Obsessive-Compulsive Disorder;oculomotor;Parkinson Disease;patient population;Pattern;Play;Population;Prefrontal Cortex;Public Health;Publishing;Research Project Grants;response;Rewards;Role;Running;Schizophrenia;Self-control as a personality trait;Signal Transduction;Substance Addiction;System;Testing;Thinking;thought control;Time;Training;United States;Visual Fields

PROJECT_TITLE: Role of Frontal Cortex in Self-Control

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Telehealth

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

PHR: Project Narrative The objective of this project is to develop a robust multi-modal platform for remote monitoring of speech, psychomotor and cognitive function in Frontotemporal lobar degeneration (FTLD) syndromes - focusing initially on Progressive supranuclear palsy (PSP, a rapidly progressing FTLD syndrome), and later extending to Corticobasal syndrome and Frontotemporal dementia. In this Direct Phase II project, we will use wearable sensors and computerized speech, psychomotor, and cognitive assessments to create outcome measures and digital biomarkers for FTLD syndromes and will use the solution to monitor 60 PSP patients for 12 months. The developed tools will facilitate clinical trials that are focused on novel therapeutics for tau-related diseases and can be readily adapted to other neurodegenerative diseases.

PI_NAMEs: PANTELYAT, ALEXANDER Y.;VAZIRI, ASHKAN  (contact);WILLS, ANNE-MARIE

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;Affect;Algorithms;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Award;Caring;Cessation of life;Clinical Trials;Cognition;cognitive function;cognitive testing;Collection;commercialization;computerized;corticobasal syndrome;Data;Dementia;Development;digital;digital assessment;Digital biomarker;digital solutions;disability;Disease;Disease Progression;effective therapy;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Future;Grant;Home;Legal patent;Marketing;Medical Records;Monitor;Motor;motor symptom;Movement;multimodality;Multiple System Atrophy;Myotonic Dystrophy;Nervous System Disorder;Neurodegenerative Disorders;novel therapeutics;Outcome Measure;Parkinson Disease;Participant;Pathologic;Patients;Pharmacologic Substance;Phase;Pilot Projects;Progressive Supranuclear Palsy;Psychomotor Performance;Recommendation;recruit;remote monitoring;Research;sensor;Severity of illness;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Speech;Stroke;Syndrome;System;tau Proteins;Tauopathies;Technology;Testing;timeline;tool;United States National Institutes of Health;Vendor;wearable sensor technology

PROJECT_TITLE: A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE This project will create a computational framework capable of describing and estimating the time-dynamic adaptation of biological systems that occur in variable environments using imputed data sampled over multiple time points. We will apply our developed model to study the adaptation strategies utilized by SARS-CoV-2 and leukemia to evade targeting by the immune system. This project will contribute to our fundamental knowledge on the adaptation strategies that are utilized by biological systems in navigating dynamical environments, which is directly useful for better understanding treatment failure in many medical contexts such as infectious diseases and cancer.

PI_NAMEs: GEORGE, JASON  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Antigens;Biological;Biological Adaptation;Biological Process;biological systems;Clinical;Collaborations;Communicable Diseases;computer framework;Computer Models;Data;data-driven model;design;Disease;Disease Outcome;Doctor of Medicine;Doctor of Philosophy;Environment;Evaluation;fitness;Gene Expression;Generations;Goals;high dimensionality;Hybrids;Immune;Immune system;Immune Targeting;improved;in silico;Instruction;intervention effect;Knowledge;leukemia;Malignant Neoplasms;Mathematics;Medical;Modeling;Outcome;Phenotype;prevent;Recording of previous events;Request for Applications;Research;Research Project Grants;Role;Sampling;System;T-Lymphocyte;theories;Therapeutic;therapy resistant;Time;time use;Treatment Failure

PROJECT_TITLE: Quantifying phenotypic adaptation of biological systems in dynamic environments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Antimicrobial cyclic and lasso peptide natural products motivate the development of chemical strategies and novel reactions to prepare protease-resistant scaffolds for use in drug discovery. In the short term, this research will develop peptide cyclization methods to access constrained antimicrobial peptides that combat multidrug resistant bacteria. Longer term, we will use reversible peptide chemistry and computational tools to design folded lasso peptides with the goal to enable their use as customizable frameworks for addressing unmet therapeutic challenges.

PI_NAMEs: ROBERTS, ANDREW GEORGE (contact)

PROJECT_TERMS: Address;anti-microbial peptide;antimicrobial;Chemicals;Chemistry;combat;computational platform;computerized tools;Cyclic Peptides;Cyclization;design;Development;drug discovery;Goals;Gram-Negative Bacteria;human disease;innovation;Lasso;Link;MccJ25;Methods;molecular dynamics;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;novel;peptide chemical synthesis;peptide drug;Peptide Hydrolases;peptide natural products;Peptides;Periodicity;Probability;Process;programs;Reaction;Research;Resistance;scaffold;Structure;Therapeutic;Tyrosine

PROJECT_TITLE: Chemical methods to prepare bioactive cyclic and lassoed peptide therapeutics


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

PHR: Project Narrative  The PI will address three significant challenges in biomechanics: the lack of a versatile technique for quantifying multiscale cell mechanics, the absence of high-precision, real-time force measurement tools at the nanoscale, and challenges in measuring in vivo dynamic mechanical regulations. This MIRA program will establish a pioneering analytical platform for biomechanics, from building a comprehensive library of Molecular Force Gauges (MFGs), integrating MFGs into various biological targets for precise biomechanical measurements, to developing a state-of-the-art super-resolution biomechanical microscopy, BM-STORM, to visualize cellular and subcellular biomechanics with unprecedented detail. Our long-term vision is to advance biomechanics for in vivo biomechanical testing, three-dimensional biomechanical mapping, and deep-tissue biomechanical monitoring.

PI_NAMEs: LU, XIAOCUN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Atomic Force Microscopy;Biological;biomechanical test;Biomechanics;Cells;Chemistry;clinical application;Complex;Darkness;Data Analyses;design;Dimensions;Disease;Engineering;flexibility;Fluorescence Resonance Energy Transfer;force sensor;frontier;in vivo;in vivo imaging;innovation;insight;interdisciplinary approach;Life;Maps;Measurement;Measures;mechanical force;Mechanics;Membrane;Methodology;Methods;Microscopy;Molecular;Molecular Bank;Monitor;nanoscale;Nature;operation;Optics;Organism;Pathology;Positioning Attribute;programs;Protocols documentation;reconstruction;Regulation;Research;Research Personnel;Resolution;response;superresolution microscopy;System;Techniques;Technology;Time;Tissues;tool;ultra high resolution;viscoelasticity;Visualization

PROJECT_TITLE: Advancing Visualization and Quantification of Subcellular and Biomolecular Mechanics through Mechanochemical Protocols


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our proposed strategy utilizes both ontology and NLP methods to streamline ADRD-related BSSR data standardization and integration. By establishing a shared ontological framework and employing NLP for information extraction, we aim to foster interdisciplinary collaboration among researchers from diverse fields, facilitating a more comprehensive understanding of ADRD and its behavioral and social aspects. This integrated approach improves data quality, accessibility, and the ability to uncover insights critical to ADRD research.

PI_NAMEs: BIAN, JIANG ;TAO, CUI  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior assessment;Behavior Therapy;Behavioral;behavioral and social science;Caregiver Burden;caregiver education;Caregivers;Caring;Clinical;Clinical Data;Clinical Pathways;Cognitive;cohort;Collaborations;Communities;coping mechanism;Data;data integration;data quality;Data Set;Data Sources;data standards;deep learning;Development;Diet;Disease;Effectiveness;electronic health data;Electronic Health Record;Elements;Emotional;Ensure;Environmental Risk Factor;Evaluation;evidence base;Family;Family member;Fostering;health disparity;improved;Individual;Information Retrieval;innovation;insight;interdisciplinary collaboration;interoperability;Intervention;Knowledge;knowledge graph;large language model;Link;Literature;Machine Learning;Methods;minority communities;Names;Natural Language Processing;Nonpharmacologic Therapy;novel;Ontology;Personal Satisfaction;Physical activity;Play;Policies;Population;programs;psychologic;Research;Research Personnel;Resources;response;Risk;Role;Semantics;social;social determinants;social engagement;Social Environment;social factors;Social Interaction;social science research;Source;Specific qualifier value;Standardization;Structure;structured data;Support System;symptom management;System;Techniques;Technology;therapy development;tool;underserved community;Underserved Population;unstructured data

PROJECT_TITLE: Standardizing and Harmonizing Behavioral and Social Science Research Factors in Alzheimer's Disease through Ontology-Based Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The mission of the PsycheMERGE Network is to advance equitable precision psychiatry in learning healthcare system frameworks across the United States. During the course of this project, an interdisciplinary team of investigators at twelve academic medical centers will bring together clinical data (>29 million individuals), genetic data (>1.9 million), and an extraordinary range of scientific expertise (psychiatry, medical informatics, machine learning, statistics, genetics, sociomedical sciences, decision sciences, and ethics) to advance this mission. We will leverage this expertise and data to build on our prior success and address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice.

PI_NAMEs: SMOLLER, JORDAN W (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acute;Address;algorithm training;Algorithms;anti-depressive agents;Artificial Intelligence;artificial intelligence method;Attitude;Awareness;Basic Science;Big Data;biobank;Biology;Biomedical Research;Bipolar Disorder;Bipolar I;causal variant;Clinical;clinical application;Clinical Data;clinical decision support;clinical practice;Communities;Country;Data;data privacy;depressive symptoms;Development;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;Early Diagnosis;Early treatment;effective therapy;Effectiveness;Environment;Equity;Ethics;experience;federated learning;Funding;Genes;Genetic;genetic analysis;genetic association;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Health system;Healthcare Systems;improved;Individual;individual variation;Infrastructure;innovation;Label;large scale data;Learning;Left;Life Style;Machine Learning;machine learning algorithm;Maps;Medical;Medical Informatics;Medical Records;member;Mental disorders;Methods;Midwestern United States;Mission;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;network models;novel;Outcome;Patients;Pattern;Performance;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Prevention;privacy preservation;Process;Psychiatric Diagnosis;Psychiatry;Records;Research Personnel;response;risk prediction;Sampling;Science;Scientist;Site;social health determinants;Standardization;statistics;Strategic Planning;success;support tools;Testing;Time;tool;Training;transfer learning;Translational Research;Translations;treatment response;United States;Update;Validation;Vision;Work

PROJECT_TITLE: 2/7 PsycheMERGE: Advancing Precision Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PHR: NARRATIVE Ischemic stroke is a leading cause of death and disability worldwide. New therapeutic approaches to stroke prevention are needed to reduce its growing public health burden. By combining proteomics and genomics methods in two high-risk populations, the goal of this proposal is to identify plasma proteins that are likely to be etiologic factors for ischemic stroke, and thus potential treatment targets for its prevention.

PI_NAMEs: KALANI, RIZWAN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Address;Antibodies;Anticoagulants;Anticoagulation;Aspirin;Atrial Fibrillation;biobank;Biological Assay;Biological Process;Blood Vessels;Cause of Death;Clinical;clinical translation;cohort;Communities;Computerized Medical Record;Data;Development;disability;Effectiveness;eHealth;Etiology;follow-up;Future;genomic data;Genomics;Genotype;Goals;Health;Heart;Hemorrhage;high risk;high risk population;high throughput screening;hypertension control;Immunoassay;improved;Incidence;Individual;insight;Ischemic Stroke;Lipids;Measurement;Measures;Medical;Mendelian randomization;Methods;Modernization;multidisciplinary;new therapeutic target;novel;novel therapeutic intervention;Oral;Participant;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacy facility;Plasma;Plasma Proteins;Population;population based;Prevention;Proteins;Proteome;Proteomics;Public Health;Records;recruit;Recurrence;Reporting;Reproducibility;Research Personnel;Residual state;Risk;Risk Factors;Risk Reduction;Sample Size;Sampling;Specificity;Stroke;stroke event;Stroke prevention;stroke risk;stroke survivor;study population;Survivors;targeted treatment;Technology;Therapeutic;therapeutic target;Translating;translational study;United States

PROJECT_TITLE: Proteomics and Genomics to Identify Therapeutic Targets for Ischemic Stroke Prevention

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative During embryogenesis, cells orient their behaviors along a tissue or body axis to drive essential processes such as neural tube closure and axis elongation. The highly conserved Planar Cell Polarity pathway allows cells to coordinate directional information between neighbors but the ‘directional cues’ that function upstream of the pathway to link it to a tissue axis remain unknown. Utilizing the mammalian skin as a model system, this research aims to overcome challenges in identifying and characterizing directional cues to yield fundamental insight into the mechanisms that organize cells across great distances.

PI_NAMEs: CETERA, MAUREEN PATRICIA (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Animals;Behavior;Biological Models;Birds;cell behavior;cell motility;Cell Polarity;Cells;Communication;Congenital Heart Defects;Consensus;Couples;Cues;Defect;developmental disease;embryo tissue;Embryonic Development;Epidermis;extracellular;Feathers;Goals;Growth;insight;Integral Membrane Protein;interest;Lead;Link;Mammals;Membrane Proteins;Modeling;Morphology;Mus;Mutation;Neural Tube Closure;Pathway interactions;Pattern;Phenotype;planar cell polarity;Process;Property;Proteins;Research;Role;self organization;Side;Signal Transduction;Skin;Tissue Differentiation;Tissues;trafficking;Variant

PROJECT_TITLE: Long-range coordination of planar polarity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: BETHESDA

ORG_NAME: U.S. NATIONAL INST/NEURO/DS/STROKE

PHR: Project Narrative Microtubule networks in neurons are coated in an array of microtubule associated proteins (MAPs) which regulate microtubule stability, spacing, and motor protein binding, but the mechanisms governing their formation into distinct patterns for efficient cargo transport remain unclear. The proposed experiments aim to use human neurons to elucidate the establishment of MAP pattern and their impact on microtubule modifications and intracellular transport. Given the large number of neurodevelopmental and neurodegenerative disorders linked to MAP or tubulin PTM disfunction, this project will provide insights into understanding disease mechanism.

PI_NAMEs: CLEARY, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Acetylation;Alzheimer's Disease;Area;Axon;Binding;Binding Proteins;Binding Sites;Biological Assay;Capsicum;career;Cell Differentiation process;Cells;Cellular biology;cellular imaging;Code;Competitive Binding;Consultations;Coupled;CRISPR interference;CRISPR/Cas technology;crosslink;Cytoskeleton;Dedications;Dendrites;Deposition;Detection;Disease;Dynein ATPase;Enzymes;experimental study;Feedback;Fellowship;Foundations;Frontotemporal Dementia;Functional disorder;Generations;Genetic Engineering;Health;Human;human disease;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;insight;Intracellular Transport;Island;Kinesin;Kinetics;knock-down;Knowledge;Length;Light;light microscopy;Link;lissencephaly;Maps;Measures;meter;Microscopy;Microtubule Bundle;Microtubule-Associated Proteins;Microtubules;Missense Mutation;Modification;molecular imaging;Molecular Motors;Monitor;Morphology;Motility;Motor;nanopattern;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;Pattern;Pattern Formation;Physical condensation;Play;Post-Translational Protein Processing;Process;programs;Proteins;reconstitution;Regulation;Regulatory Pathway;Research;Resolution;Role;single molecule;Spatial Distribution;spatiotemporal;Stereotyping;superresolution microscopy;tau Proteins;Techniques;Total Internal Reflection Fluorescent;trafficking;Training;Tubulin;ward;Work

PROJECT_TITLE: Functional interplay between MAP and PTM patterns in the human neuron

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: Project Narrative The proposed research will investigate biomolecular aspects of thiyl radical formation, chemistry, and reduction relevant to the fidelity of thiyl radical enzymes and their non‐specific reactivity. These studies will employ a variety of techniques and investigate thiyl radicals in a number of distinct contexts, broadening the impact of the findings. Ultimately, outcomes of the proposed work will inform rational therapeutic design, open the door for thiyl radical biocatalysis engineering, and strategic approaches to intercept reactive sulfur species involved in oxidative stress.

PI_NAMEs: GREENE, BRANDON  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Regulation and maintenance of thiyl radicals in enzyme catalysis and protein degradation

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: CHARLOTTE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: PROJECT NARATIVE Despite being a key step in the central dogma of biology, there are major gaps in our knowledge of the dynamics and downstream effects of the interaction between codons and tRNAs. This project explores the evolutionary and cellular consequences of codon biases and tRNA fluctuations. The findings of this work are critical to the construction of evolutionary models and our understanding of cellular regulation.

PI_NAMEs: LABELLA, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Amino Acids;Biological;Biological Models;Biology;cell growth regulation;Cells;Cellular biology;Codon Nucleotides;Collaborations;Computer Models;Data;Data Set;Equilibrium;Evolution;Gene Expression;Genes;Genetic Transcription;Genome;genomic tools;Growth;Knowledge;lens;Machine Learning;machine learning method;Messenger RNA;Methods;Modeling;Modernization;Mutation;novel;Phenotype;Phylogeny;protein expression;Recording of previous events;Regulation;Research;Ribosomes;Role;Saccharomycetales;Scheme;Shapes;skills;Study models;System;Testing;trait;Transfer RNA;Work

PROJECT_TITLE: Role of codon usage bias in eukaryotic evolution and regulation


NIH_SPENDING_CATS: Genetics

ORG_CITY: LITTLE ROCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE Alternative splicing is coupled with nonsense-mediated mRNA decay (AS-NMD) to regulate gene expression. AS-NMD is often fine-tuned in a tissue-specific manner and frequently dysregulated in diseases, including neurological disorders, cardiac myopathies, diabetes, lupus, and different malignancies. Here, we will elucidate molecular mechanisms and therapeutic strategies targeting AS-NMD errors in specific diseases.

PI_NAMEs: RAHMAN, MOHAMMAD ALINOOR (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Alternative Splicing;Attention;Biological Models;Biological Process;Brain;Cardiac;Cell model;Clinical;Code;Coupled;Defect;Development;Diabetes Mellitus;Disease;Disease susceptibility;Gene Expression;Gene Expression Regulation;Generations;Genes;Hematopoietic;Human;human disease;Human Genome;innovation;Liver Dysfunction;Lupus;Malignant Neoplasms;Mediating;Messenger RNA;Molecular;mRNA Decay;Mutate;Myocardial dysfunction;Myopathy;Neoplasms;Nervous System Disorder;Noise;Normal Cell;Oligonucleotides;Outcome;overexpression;Pathologic;Pathway interactions;Pharmacology;Physiological;Physiology;Play;premature;preservation;Protein Isoforms;Proteins;Regulation;RNA;RNA Processing;RNA Splicing;Role;Technology;Terminator Codon;Therapeutic;Tissues;tool;Translations

PROJECT_TITLE: Decoding Mechanisms of Nonsense-mediated mRNA Decay through Alternative Splicing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_NAME: U.S. NATIONAL INSTITUTE ON DRUG ABUSE

PHR: Project Narrative Environmental enrichment demonstrates promise as a therapeutic tool for excessive alcohol use in animal models. However, studying the effects of environmental enrichment in humans has been difficult. This proposal seeks to fill this gap by developing a virtual reality-based methodology to rigorously test the effects of environmental enrichment on craving for alcohol in people with alcohol use disorder.

PI_NAMEs: TYLER, RYAN EDWARD (contact)

PROJECT_TERMS: addiction;Alcohol consumption;alcohol craving;alcohol cue;alcohol demand;alcohol exposure;alcohol relapse;alcohol response;alcohol use disorder;Alcohols;Animal Model;anxiety-like behavior;Apoptosis;Attention;Attenuated;Biological;Blood specimen;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Collaborations;collaborative environment;Complex;Consumption;craving;cue reactivity;Cues;Data;depressive symptoms;Development;Diabetes Mellitus;Diagnosis;diagnostic criteria;digital;Disease;DSM-V;Economics;Environment;environmental enrichment for laboratory animals;Etiology;Exposure to;Feeding behaviors;Galvanic Skin Response;Gene Expression;Genes;ghrelin;glucagon-like peptide 1;glucose metabolism;Growth;Growth Factor;Heart Rate;Homeostasis;Human;Impairment;improved;improved outcome;Inpatients;Insulin;Investigation;Leptin;Letters;Measures;Mediating;Mental Depression;Metabolic;Metabolism;Methodology;Modality;Molecular;Morbidity - disease rate;mortality;Motivation;multisensory;neural growth;Neurobiology;neurogenesis;Neuronal Plasticity;neuropsychiatric disorder;NGFR Protein;novel;Obesity;Ontology;Organism;Outcome Measure;Participant;Pathway interactions;Patients;Performance;performance tests;Peripheral;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Physiological;pre-clinical;preclinical study;Procedures;programs;Protein Precursors;Protocols documentation;Publishing;receptor;Receptor Signaling;remediation;Research;response;Rodent Model;Self Administration;Signal Pathway;Signal Transduction;Structure of beta Cell of islet;synaptogenesis;Techniques;Technology;Testing;Therapeutic;Time;tool;transcriptome sequencing;translational approach;Translations;Tropomyosin;Validation;virtual reality;virtual reality intervention;Western Blotting;Withdrawal;Work

PROJECT_TITLE: Effects of virtual reality-based environmental enrichment on alcohol craving


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Based on strong preliminary data we propose that the transcription factor ThPOK serves as a critical transcriptional checkpoint for neutrophil commitment in granulocyte lineage-specified cells and thereby enforces a set point for granulocyte lineage output. Here we will dissect the upstream pathways that control ThPOK induction during myelopoiesis, the modus operandi by which ThPOK controls transcription, and its importance for emergency myelopoiesis. Completion of these studies will provide critical insights into the contribution of ThPOK to homeostatic and emergency myelopoiesis and provide a conceptual basis for the future design of therapeutic strategies for the treatment of neutropenia, sepsis, and Myeloproliferative Disorder through targeting of ThPOK and its associated pathways.

PI_NAMEs: BASU, JAYATI  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Ablation;Acceleration;Aging;Animal Model;Binding Sites;Biological Assay;Blood Cells;Bone Marrow;CD4 Positive T Lymphocytes;Cells;ChIP-seq;Chromatin;cofactor;CSF3 gene;cytokine;Cytokine Receptors;Cytokine Signaling;Data;design;Development;Disease;DNA Binding;Elements;Emergency Situation;Enhancers;Epigenetic Process;Exhibits;first responder;functional outcomes;Future;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;granulocyte;Granulopoiesis;Growth Factor;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;Immunity;In Vitro;Infection;Inflammatory;insight;Interleukin-1;Knock-in Mouse;Knockout Mice;Knowledge;loss of function;Malignant Neoplasms;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;mutant mouse model;Mutant Strains Mice;Mutation;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Myeloproliferative disease;Names;Neutropenia;neutrophil;Neutrophilia;new therapeutic target;novel;NuRD complex;Output;Pathogenicity;Pathologic;Pathway interactions;Physiological;Play;Production;progenitor;programs;Receptor Signaling;recruit;Regulation;Reporter;response;Role;Sepsis;Signal Transduction;Specific qualifier value;stem;stem cell fate specification;stem cell population;T-Cell Development;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Transcriptional Silencer Elements;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Transcriptional regulation of Myelopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative The majority of metabolites in the human body remain unknown, yet these metabolites may play a critical role in important biological mechanisms such as disease pathogenesis. This proposal uses a strategy called reverse metabolomics, which combines organic synthesis, mass spectrometry and public data mining for the high-throughput characterization of small molecules in humans. Ultimately, this approach offers insight into new disease biomarkers, druggable pathways and bioactive small molecules.

PI_NAMEs: GENTRY, EMILY  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Biological;Biological Markers;Data;data mining;Detection;Disease;experimental study;Goals;Human;Human body;insight;interest;Libraries;Maps;Mass Spectrum Analysis;metabolome;metabolomics;Methods;Neurotransmitters;novel;Organic Synthesis;Pathogenesis;Pathogenicity;Pathway interactions;Physiology;Play;potential biomarker;Process;Research;Role;small molecule;Sphingolipids;Structure;therapeutic target;Work

PROJECT_TITLE: Mapping the Human Metabolome Using Synthesis and Mass Spectrometry


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Research on solitude and gerotranscendence is siloed, despite significant overlap in the context of older adults. Ambiguous constructs within each field make integration challenging, but also motivate our project "Promoting Health Aging through Semantic Enrichment of Solitude Research (PHASES)" which seeks to integrate these fields by developing ontologies and a web portal to foster innovative research on healthy aging.

PI_NAMEs: BEVERLEY, JOHN  (contact);DUNCAN, WILLIAM

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adult;age-related disease;Aging;aging related;Area;Attention;Basic Science;behavior change;Biological;biomedical ontology;Communities;Complex;computer based Semantic Analysis;Consensus;Data;data modeling;Development;developmental psychology;Disparate;Educational workshop;Engineering;Evaluation;Exercise;Exhibits;expectation;experience;Fast Healthcare Interoperability Resources;Florida;Fostering;Foundations;Goals;Health;Health Promotion;healthy aging;human old age (65+);Individual;Inequity;Infrastructure;innovation;insight;interest;Intervention;intervention refinement;Intervention Studies;Investigation;Knowledge;Link;Literature;Loneliness;Longevity;Maps;Measurement;meetings;Mental Depression;Michigan;middle age;Mission;mortality;multidisciplinary;natural language;novel;older adult;Ontology;open data;Outcome;pandemic disease;Pathology;Peer Review;Personal Satisfaction;physical separation;Population;Positioning Attribute;preference;Process;psychologic;Public Health;Publications;Recommendation;Research;Research Personnel;Risk;Role;Safety;Semantics;social;Social isolation;Societal Factors;Students;success;symposium;System;technical report;Technology;theories;Time;Training;undergraduate student;United States National Library of Medicine;Universities;web interface;web portal;Well in self;Work


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Data Science;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Complementary medicine (CM) interventions are increasingly used by health care consumers and accepted by the medical community, although much remains poorly understood about their effectiveness and safety as well as the underlying biological mechanisms through which they affect health and well-being. Published literature is a growing source of evidence on CM approaches; however, much of this evidence remains in unstructured text in specialty journals, creating barriers for effectively integrating the evidence with conventional medicine. The proposed research will develop informatics resources (ontology, knowledge graphs) and literature mining tools to consolidate the high-quality evidence on CM approaches and integrate it with conventional medicine in a machine-readable and AI-ready form, and will demonstrate the utility of these resources for knowledge management and scientific discovery in complementary and integrative health.

PI_NAMEs: KILICOGLU, HALIL  (contact);TAO, CUI ;ZHANG, RUI

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Adult;Affect;base;Biological;Biological Process;biomedical informatics;Body System;Clinical Data;Collaborations;Communities;comparative;Complementary Health;Complementary Medicine;Databases;Development;Diet;dietary;dietary supplements;Disease;Disparate;Effectiveness;Electronic Health Record;evidence base;Evidence based practice;Food Supplements;Fostering;Future;Generations;Goals;graph knowledge base;Growth;gut microbiome;Health;Health Surveys;Healthcare;Human;Human Microbiome;Immunology;improved;individual patient;Informatics;information organization;Information Resources;Information Retrieval;innovation;insight;Integrative Medicine;Intervention;Journals;Knowledge;knowledge base;knowledge curation;Knowledge Extraction;knowledge graph;knowledge integration;Knowledge Management;large language model;Literature;Manuals;Medical;medical specialties;Medicine;Metabolism;metabolomics;Metagenomics;Methods;microbiome;Modeling;National Center for Complementary and Integrative Health;Natural Language Processing;Neural Network Simulation;novel;Ontology;Patient Care;Personal Satisfaction;pharmacovigilance;psychologic;Publishing;Readability;Research;Research Personnel;Resource Informatics;Resources;Role;Safety;Source;Standardization;Strategic Planning;Structure;System;Terminology;Text;text searching;tool;training data;Translating;United States;Validation;whole health;Work

PROJECT_TITLE: COMBINI: connecting COmplementary Medicine evidence and BIological kNowledge to support Integrative Health

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE: In Bangladesh and other low- and middle-income countries (LMICs) antibiotics are readily used to treat acute lower respiratory infections even though most are caused by viruses. Novel tools for diagnosing pediatric respiratory diseases that are feasible for application in LMICs are desperately needed to safely improve outcomes while strengthening antibiotic stewardship. The BLAAST Project plans to conduct a randomized, double-blinded, placebo, non-inferiority trial of pediatric care enhanced by a novel automated digital stethoscope, compared to standard care, in Bangladesh (Aim 1) with an integrated implementation assessment (Aim 2) and economic evaluation (Aim 3) over a period of three years among low-risk children with IMCI-defined pneumonia.

PI_NAMEs: MCCOLLUM, ERIC DOUGLASS (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Acute;Address;Ambulatory Care;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;arm;Artificial Intelligence;Asia;Asian population;Auscultation;Award;Bacterial Infections;Bacterial Pneumonia;Bangladesh;Caregivers;Caring;Catchment Area;Cessation of life;Chest;Child;Child Care;Child health care;Childhood;classification algorithm;Clinic;Clinical;clinical decision-making;clinical efficacy;Clinical Management;comparative cost effectiveness;Computer software;cost;cost effective;cost effectiveness;cost estimate;Crackles;Decision Making;design;Devices;Diagnosis;Diagnostic Specificity;diagnostic strategy;diagnostic technologies;diagnostic tool;digital;disability-adjusted life years;Double-Blind Method;economic evaluation;Effectiveness;efficacy evaluation;eHealth;Eligibility Determination;enhanced care;Evaluation;Exclusion;experience;FDA approved;Focus Groups;Frequencies;Friends;Guidelines;Health Personnel;Healthcare;implementation evaluation;improved;improved outcome;Individual;innovation;Intention;Intervention;Interview;low and middle-income countries;Lower Respiratory Tract Infection;Lung;Masks;Methods;Morbidity - disease rate;Morphologic artifacts;mortality;Noise;novel;opportunity cost;Outcome;Outpatients;Participant;Perception;Physicians;Placebos;Pneumonia;Population;primary outcome;Private Sector;Process;Quality of Care;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Resources;respiratory;Respiratory Disease;Respiratory Sounds;Risk;Role;routine care;Rural;sound frequency;South Asian;standard care;stem;Stethoscopes;Structure;Time;tool;Training;Translating;transmission process;treatment arm;Treatment Failure;United States National Institutes of Health;Vaccinated;Vaccination;Variant;Virus;Virus Diseases;Wheezing

PROJECT_TITLE: The BLAAST Trial:  Bangladesh Lung Auscultation AI for Antibiotic Stewardship Randomized Controlled Trial


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Bacteria communicate through molecules on their surface, called glycans, which can help them invade our bodies. Our research investigates these molecules and how they interact, using advanced computational techniques. In doing so, our goal is to advance our knowledge of bacterial glycan behavior, leading to new ways to enhance health and prevent infections.

PI_NAMEs: MINKARA, MONA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Amino Sugars;Bacteria;Behavior;Binding;Biological Assay;Biological Models;Cells;Collectins;Communication;Communication Methods;Computational Technique;Computer Models;Computer software;computerized tools;design;Docking;efficacy testing;Fimbriae Proteins;Foundations;Glycobiology;Goals;Health;Human;in silico;In Vitro;in vivo evaluation;Infection prevention;Invaded;Investigation;Knowledge;Libraries;Link;Mission;Modeling;novel therapeutic intervention;Peptidoglycan;Polysaccharides;Process;programs;Pseudomonas aeruginosa;Pulmonary Surfactant-Associated Protein D;Research;Research Design;Research Personnel;Serotyping;Software Tools;Structure;Surface;synergism;Update;Validation;Vision

PROJECT_TITLE: Foundational Investigations into Bacterial Surface Glycan Dynamics


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE As the volume of human genome sequencing data continues to grow, most sequence variants identified are of unknown biological significance, thus our ability to leverage these data for the improvement of human health is limited by variant interpretation challenges. We have developed novel bioinformatic tools to interrogate human sequencing data and deployed these tools to discover rare and putatively deleterious variants in genes involved in inflammation. In this project, we will use in-depth molecular and cellular assays to decipher the functional impacts of these novel variants, and in addition, we will use a DNA biobank linked to electronic health records to uncover new genotype-phenotype relationships at a population scale.

PI_NAMEs: MARKLE, JANET G (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Amaze;biobank;bioinformatics tool;Biological;Cell Communication;Cells;Cellular Assay;Childhood;chronic inflammatory disease;Clinical;cohort;complex biological systems;Data;Disease;DNA;Drug Design;Electronic Health Record;experimental study;Genes;Genetic;Genetic study;genetic variant;genome wide association study;Genotype;Glean;Health;Human;Human Genetics;human genome sequencing;Immune;Immune response;Immune signaling;Immune system;Immunologics;Immunosuppressive Agents;improved;Individual Differences;individual patient;Inflammation;Inflammatory;insight;inter-individual variation;knockout gene;Knockout Mice;Lead;Link;Medical;Mendelian disorder;Methods;migration;Molecular;mouse model;Mus;Mutate;Mutation;novel;Orthologous Gene;Pathogenesis;Pathway interactions;Patients;personalized medicine;Phenotype;Population;Process;programs;Proteins;Public Health;Refractory;Research;Resolution;Sampling;Self-Injurious Behavior;Signal Pathway;Signal Transduction;Specific qualifier value;Therapeutic;therapeutic candidate;therapeutic target;tool;Untranslated RNA;Variant;Work

PROJECT_TITLE: From genetic variants to mechanisms: understanding drivers of inflammation


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Internal ribosome entry sites (IRESs) are structured RNAs essential for translation of viral mRNAs and for translation of circular mRNAs—a promising new class of mRNA therapeutics with applications ranging from cancer immunotherapy to genome editing. This proposal will investigate how IRESs initiate translation and build potent IRES-based expression technologies. These studies will inform the treatment and prevention of viral infectious diseases and advance circular-mRNA technologies for research and therapeutics.

PI_NAMEs: LI, LI  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Base Pairing;Biochemical;cancer immunotherapy;Chemicals;Communicable Diseases;Complex;Cryoelectron Microscopy;design;Development;Elements;Gene Expression;Genetic Transcription;genome editing;Goals;immunogenicity;insight;interest;Internal Ribosome Entry Site;Introns;knowledge base;Mediating;Messenger RNA;Modification;Molecular;molecular modeling;Mutation;Nucleosides;Nucleotides;Prevention;Protein Biosynthesis;Pseudouridine;Research;Resolution;RNA;RNA Folding;Structure;System;Techniques;Technology;Therapeutic;three dimensional structure;Translating;Translation Initiation;Translations;Untranslated RNA;Uridine;Viral;virtual;Virulence

PROJECT_TITLE: IRES-mediated translation: mechanisms and applications in mRNA therapeutics


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Women at high risk of breast cancer have opportunities for breast cancer risk reduction, including risk-reducing medications and more intensive breast cancer screening. The goal of this proposal is to determine whether new Artificial Intelligence (AI) technologies can accurately identify women at high risk of breast cancer who may benefit from risk reduction. The project will draw on a large, diverse group of women undergoing routine mammography screening across the United States to ensure that these new AI technologies perform equally well in women of all race and ethnicity groups.

PI_NAMEs: LOWRY, KATHRYN PAIGE (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Academy;Address;Adoption;advanced breast cancer;Advanced Malignant Neoplasm;Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Benefits and Risks;Big Data;black women;Breast Cancer Detection;Breast Cancer Epidemiology;Breast Cancer Model;Breast Cancer Prevention;breast cancer registry;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast imaging;cancer care;Cancer Intervention and Surveillance Modeling Network;cancer risk;Cessation of life;Chemoprevention;Clinical;clinical practice;clinical risk;Continuity of Patient Care;Data;Eligibility Determination;Equity;Ethnic Population;Evaluation;Goals;Health;high risk;High Risk Woman;Hispanic Women;Image;improved;improved outcome;Incidence;Individual;Inequity;innovation;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Measures;Medicine;Modeling;models and simulation;Outcome;Patient-Focused Outcomes;Performance;Pharmaceutical Preparations;Physicians;Policy Maker;Population;precision medicine;Prevention;Prognosis;racial population;randomized trial;Registries;Reporting;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;routine screening;Sampling;screening;Secondary Prevention;supplemental screening;Technology;Technology Assessment;tool;United States;United States Food and Drug Administration;White Women;Woman;Women's Group;women's outcomes;Work

PROJECT_TITLE: Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Microbiome

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative: Intestinal mucus serves as a nutrient source and signaling molecule for microbes residing in the gut. Our understanding of the impact of mucus on the composition and function of gut bacteria, as well as the reciprocal regulation of goblet cells by microbes, is still in its early stages. This proposal has the potential to advance our comprehension of bacterial ecology and the interactions between bacteria and their host, offering exciting prospects for further exploration in this field.

PI_NAMEs: ENGEVIK, MELINDA ANNE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Bacteria;Communication;Communities;Complex;Comprehension;Disease;Ecology;Ecosystem;Fostering;Gastrointestinal tract structure;Glean;Glycoproteins;Goals;Goblet Cells;gut bacteria;gut health;gut microbes;gut microbiome;gut microbiota;Health;host-microbe interactions;Human;innovation;insight;interdisciplinary approach;Intestines;Investigation;Link;metabolomics;Microbe;Microbiology;microbiota;Mission;Mucins;Mucous body substance;Nutrient;pandemic disease;Personal Satisfaction;Play;Process;Production;programs;Reagent;Regulation;Research;resident commensals;Resources;Role;Signal Transduction;Signaling Molecule;Source;Techniques;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Exploring the complex interactions between gut microbes and mucus

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The gut microbiome contributes to interindividual variability in drug responses, including efficacy and toxicity. By studying bacterial drug metabolism, we will develop strategies to predict and prevent drug-induced injury and reduce medication side effects, thus promoting public health. This research program will utilize samples from individuals of diverse races and ethnicities often understudied in biomedical research to understand how the microbiome alters drug response, thereby delivering on the promise of precision medicine for all.

PI_NAMEs: BHATT, AADRA PRASHANT (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adverse effects;Adverse event;Age;Automobile Driving;Award;Bacteria;bacterial metabolism;Beta-glucuronidase;Biomedical Research;career;drug disposition;drug metabolism;Drug Side Effects;Drug toxicity;Enzymes;ethnic diversity;Ethnic Origin;Ethnic Population;frontier;Future;Genetic;genetic manipulation;Glucuronidase Inhibitor;Glucuronides;Goals;gut microbiome;Human;improved;Individual;Injury;Integration Host Factors;inter-individual variation;Intestines;Lead;Mediating;Metabolism;Microbe;microbiome alteration;microbiota;Molecular;Organ;Pharmaceutical Preparations;pharmacokinetic model;Phase;phenotypic biomarker;Physiology;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;precision medicine;preclinical development;Predisposition;preference;prevent;Primary Cell Cultures;programs;Public Health;racial diversity;Research;Research Personnel;response;Sampling;sex;side effect;Testing;Tissues;tool;Toxic effect;Work

PROJECT_TITLE: Pharmacomicrobiomics: The Frontier of Interindividual Variability in Drug Response


PHR: Project Narrative  PRMT5 is a therapeutic target in cancer and neurodegenerative disease; however, why cells require arginine methylation by PRMT5 for survival remains largely unresolved. The following research proposal will comprehensively dissect the role of the essential methyltransferase PRMT5. In the present work, we will discern which PRMT5 methyl substrates are required for cell survival in disease and normal settings, and how arginine methyl events impact substrate protein function.

PI_NAMEs: MULVANEY, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Amino Acid Motifs;Arginine;Binding;Binding Sites;Biochemical;Biology;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Charge;Chromatin;computerized tools;Disease;enzyme activity;Enzyme Inhibitor Drugs;enzyme substrate;Enzymes;Event;Family;Future;Genetic Transcription;Hydrogen Bonding;Hydrophobicity;Malignant Neoplasms;Mechanics;Messenger RNA;methyl group;Methylation;Methyltransferase;Neurodegenerative Disorders;new therapeutic target;Normal Cell;Normal tissue morphology;novel;Outcome;Pathway interactions;Post-Translational Protein Processing;preservation;Process;programs;protein complex;protein function;Proteins;recruit;Regulatory Pathway;Research;Research Proposals;RNA;RNA Binding;RNA Splicing;Role;Site;Structure;Testing;Therapeutic;therapeutic target;Tissue Survival;Toxic effect;Translations;Validation;Work

PROJECT_TITLE: Resolving cellular functions of arginine methylation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

PHR: NARRATIVE Both soluble and bound ligands play pivotal roles in regulating cell behavior and function, particularly in tissue vascularization and chronic wound healing. This proposal aims to pioneer innovative methods to fabricate multi-structured, heterogenous angiogenic hydrogels with variable ligand binding affinities as a platform to better understand how combined structural and biochemical cues orchestrate cell signaling, and to harness these insights for enhanced vasculature. Outcomes from the proposed research will elucidate differential signaling impacts and mechanisms for binding growth factors and adhesive ligands covalently and noncovalently, offering accelerated vascularization strategies for therapeutic wound healing.

PI_NAMEs: LI, LINQING  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Acceleration;Adhesions;Adhesives;Affinity;angiogenesis;Angiogenic Factor;Binding;Biochemical;Biocompatible Materials;Biomedical Engineering;Biomimetics;Biophysics;Blood Vessels;cell behavior;cell motility;Cell Physiology;Cells;Charge;Chemicals;Chronic;chronic wound;Complex;Cues;Deposition;design;Diabetic mouse;Ensure;Equilibrium;Extracellular Matrix;fabrication;Fibrosis;Goals;Growth;Growth Factor;healing;Heparin;Hydrogels;In Vitro;Infiltration;innovation;insight;Integrins;Ligand Binding;Ligands;Liquid substance;mechanotransduction;Mediating;Methods;Microfluidics;Microspheres;mimetics;model building;Modeling;mouse model;novel;Outcome;Peptide Initiation Factors;Phase;Physiological;Play;Process;Property;Research;response;Role;Route;Signal Transduction;Specificity;Structure;synergism;System;Techniques;Therapeutic;Tissues;Vascularization;wound;wound closure;wound healing;Wound healing therapy;wound injury

PROJECT_TITLE: Combining soluble and bound factors in microstructured hydrogels to promote chronic wound angiogenesis and healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative The natural wound microenvironment and the biomaterials implanted to support its healing present complex biophysical and biochemical properties that must be navigated by invading endothelial cells, fibroblasts, and mesenchymal stromal cells during tissue repair. Hydrogels with tailorable properties like the one we propose to use allow the controlled culture of relevant cells in biomimetic environments allowing fundamental insights into cell behavior and their sensitivity to microenvironmental features. Our proposed projects will advance the basic understanding of endothelial cell invasion leading to angiogenesis, fibroblast activation leading to fibrotic scarring, and stromal cell paracrine signaling in wound-mimicking environments, ultimately enabling the discovery of broadly applicable tissue regenerative therapies.

PI_NAMEs: QAZI, TAIMOOR HASAN  (contact)

PROJECT_TERMS: Address;angiogenesis;Area;Award;Biochemical;Biocompatible Materials;Biomimetics;Biophysics;Body System;cell behavior;Cell model;Cell Physiology;cell type;Cells;Cicatrix;clinical translation;Complex;density;Deposition;design;Endothelial Cells;Endothelium;Environment;Experimental Designs;Fibroblasts;Funding;Goals;healing;Hydrogels;Implant;improved;In Vitro;in vitro Model;Infiltration;Injectable;Injury;insight;Invaded;Knowledge;Ligands;matrigel;Mechanics;mesenchymal stromal cell;migration;Outcome;Paracrine Communication;Play;Porosity;Process;programs;Property;Rationalization;regenerative therapy;regenerative tissue;Research;Research Personnel;Role;severe injury;Stromal Cells;Therapeutic;tissue repair;Tissues;wound;wound healing

PROJECT_TITLE: Leveraging cell-instructive hydrogels to understand microenvironmental impact on wound healing processes

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Mutations that impact the processing of miRNAs cause different genetic syndromes, including the bone marrow failure syndrome poikiloderma with neutropenia, where patients have mutations in the 3' - end miRNA deandenylase USB 1. In this proposal our goal is to understand the molecular mechanisms leading to hematopoietic failure in settings of altered miRNA processing, and find mechanisms to restore blood development in patients. We will use a unique combination of molecular and cellular tools that will significantly increase current knowledge on miRNA stability and function in blood cells that are deficient in patients with mutant USB 1.

PI_NAMEs: BATISTA, LUIS FRANCISCO ZIRNBERGER (contact)

PROJECT_TERMS: adenylate;Apoptosis;Biogenesis;Biological Assay;Biology;Blood;Blood Cells;blood formation;bone marrow failure syndrome;Cell Line;Cell Proliferation;cell type;Cells;Complement;Complex;Data;Degradation Pathway;Development;DNA;Ensure;Exonuclease;exosome;Failure;Future;Gene Expression;Genetic;genome-wide;Goals;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Hematopoietic System;Human;human embryonic stem cell;human pluripotent stem cell;human tissue;Impairment;In Vitro;in vivo;Intervention;Knowledge;Mediating;MicroRNAs;Modeling;Molecular;mutant;Mutation;Myeloid Progenitor Cells;Neutropenia;neutrophil;novel;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiological;Play;Poly(A) Tail;Polyadenylation;Polymerase;Population;Positioning Attribute;Post-Transcriptional Regulation;Process;progenitor;Protocols documentation;RNA;RNA Decay;RNA Degradation;RNA Processing;Role;Route;Silicon Dioxide;Specificity;stem;stem cells;Syndrome;Tail;Testing;Tissues;tool;Transcriptional Regulation;transcriptome;ubiquitin ligase;Untranslated RNA

PROJECT_TITLE: Mechanisms and relevance of miRNA decay during hematopoietic development

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]