ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: This health services research center will produce innovations that augment the value, accessibility and quality  of health care in the Veterans Health Administration and in the United States as a whole. Our extensive, deep  and longstanding connections to implementation research centers and delivery system partners will ensure  that the innovations we test make a difference. We will focus particularly on value-promoting opportunities in  mental health care (including substance use disorder) and medical specialty care (including heart, liver, and  renal disease). Improving value, accessibility and quality in these areas will significantly benefit both the  Veterans we serve and the overall health care system.

PI_NAMEs: ASCH, STEVEN M. (contact)

PROJECT_TERMS: Address;Area;Breeding;California;career development;Caring;Chronic Care;Chronic Disease;Clinical;Coin;Collaborations;cost;cost effectiveness;design;Ensure;Environment;Face;Fostering;frontier;Goals;Health;health care quality;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;Heart Diseases;Homogeneously Staining Region;Hospital Costs;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Kidney Diseases;Learning;Liver diseases;medical specialties;Mental Health Services;Mentors;Methodology;Methods;Mission;Modeling;next generation;Organizational Innovation;Outcome;Pharmaceutical Preparations;Primary Care;Procedures;Provider;Research;Research Personnel;Research Support;Resource Allocation;Resources;Role;San Francisco;Self Care;Special Population;Specialist;Structure;Substance Use Disorder;System;Technology;Testing;United States;Universities;Value Orientations;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Center for Innovation to Implementation (Ci2i): Fostering High Value Health Care

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducting and promoting research in additional areas including cancer prevention and control, health aging, and other timely topics. CCDOR has deep and strong partnerships with VA Program Offices, including the Office of Mental Health and Suicide Prevention, the National Center for PTSD, and National Pain Management. These and other partnerships ensure the value and impact of Center research.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: acronyms;Aging;Area;Cancer Control;cancer prevention;care delivery;care outcomes;chronic pain;Communities;community based participatory research;community engagement;data management;Dedications;Disease;Ensure;Equitable healthcare;Evidence based practice;experience;Family;functional outcomes;Goals;Harm Reduction;Health;health care delivery;Health Services;Health Services Research;health training;Healthcare;Healthcare Systems;healthy aging;implementation research;implementation strategy;improved;Informatics;innovation;Intervention;Mental Health;Mentors;Methodology;Methods;Mission;Names;Opioid;Outcome;Outcomes Research;Pain management;Pain Research;Positioning Attribute;Post-Traumatic Stress Disorders;preservation;programs;Research;Research Personnel;Resources;Services;statistics;Strategic Planning;Structure;success;Suicide prevention;Training;Trauma;Trauma recovery;Veterans;Vision


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: The Center of Innovation for Complex Chronic Healthcare (CINCCH) is a HSR&D COIN based at Hines VA Hospital. CINCCH's mission is to conduct research to optimize coordination and contextualization of healthcare delivery and improve outcomes for Veterans with high priority neurologic conditions, disseminate and implement best evidence, and train future researchers. We utilize innovative direct observation methods to collect data that compliments other forms of data to assess quality and patient experiences. CINCCH collaborates with several VA Operations Partners and is affiliated with three universities in the Chicago area. In addition, we have established a Veterans Engagement Panel that provides feedback on grant proposals and dissemination activities. Our COIN's vision is to create the evidence and implement the findings to support and guide VA in providing the best care in the right place at the right time.

PI_NAMEs: WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Address;Antibiotics;Applications Grants;Appointment;Area;Award;bone health;Books;care coordination;career;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic;Chronic Care;Collaborations;Complex;Data;decubitus ulcer;Disease;Doctor of Medicine;Doctor of Philosophy;experience;Faculty;Feedback;Funding;Future;health care delivery;Health Care Research;Health Services;Healthcare;Homelessness;Homogeneously Staining Region;Hospitals;Illinois;improved;improved outcome;innovation;Institution;instrument;Kidney Diseases;Leadership;Life;Medicare;Mentors;Methods;Mission;Modeling;Modernization;Neurologic;operation;Paper;Patient-Centered Care;Patients;Persons;pharmacy benefit;Physical Medicine;Physical Rehabilitation;programs;Renal dialysis;Research;Research Personnel;Respiratory Tract Infections;Scientist;Services;Source;Spinal cord injury;telehealth;Time;Training;Universities;Veterans;Vision;Weight Gain;Weight maintenance regimen;Work


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: The Center for Access and Delivery Research and Evaluation (CADRE) is seeking to renew its Center of Innovation (COIN) funding to advance research and improve access for Veterans. We aim to build upon our existing expertise, established operational partnerships, and long-term research objectives through prioritizing five overarching goals that align with our focused areas of research and emerging priorities. GOAL 1: Improve access to high quality care for rural Veterans through innovative applications of telehealth in specialty care, community care, and dual use. GOAL 2: Develop and evaluate interventions targeting the multidrug-resistant organism crisis. GOAL 3: Expand efforts in developing innovative health services research in three additional areas: (1) women’s health, (2) epidemic opioid use and substance use disorders, and (3) cardiovascular outcomes. GOAL 4: Continue the Center’s success in supporting mentored career development. GOAL 5: Promote Veteran engagement with recognition that Veterans are experts on Veteran experience.

PI_NAMEs: PERENCEVICH, ELI N (contact)

PROJECT_TERMS: Address;Area;barrier to care;Cardiovascular system;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Communities;Community Healthcare;connected care;design;digital intervention;Endocrinologist;Enrollment;Equity;Evaluation;experience;Face;Fertility;Funding;Goals;health care availability;Health Services Research;Healthcare Systems;Improve Access;improved;innovation;Internet;Intervention;Iowa;Leadership;medical specialties;meetings;Mentors;multi-drug resistant pathogen;operation;opioid epidemic;opioid use;Outcome;pharmacy benefit;Poverty;Prevention;Provider;Publishing;Quality of Care;Recommendation;reproductive;Research;Research Personnel;Research Priority;Resources;Rural;rural area;Rural Health;rural setting;Scientist;Services;Substance Use Disorder;success;telehealth;Universities;Veterans;Women's Health;Women's Health Services

PROJECT_TITLE: Center for Access & Delivery Research and Evaluation (CADRE)


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This application proposes the continuation of a Center of Innovation (COIN), called the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center. The COIN builds on the successes of our existing PRIME Center at VA Connecticut Healthcare System. The goals of the PRIME Center are to conduct research to improve care for all Veterans with a specific focus on pain management and women's health. The Center also fosters innovative research in emerging areas like suicide prevention and CHOICE care. Through a Veteran Engagement Group, the Center strives to be Veteran-centric. Investigators provide research mentoring to train the next generation of VA health services researchers. To achieve its goals, the PRIME Center is supported by partnerships with VHA Patient Care Services and Operations leaders, especially the Pain Management Program and Women's Health Services, as well as a large number of cross-COIN and other VHA medical center collaborations.

PI_NAMEs: BASTIAN, LORI A (contact)

PROJECT_TERMS: Area;Award;behavioral health;Behavioral Sciences;care systems;career;career development;Caring;Chronic;Clinical;Collaborations;Complementary Medicine;Connecticut;Disparity;Eating Disorders;Education;Electronic Health Record;Fostering;gender difference;Goals;Health;health data;Health Services;Health Services Research;Healthcare;Healthcare Systems;High Prevalence;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Integrative Medicine;Intervention;Leadership;Medical;Medical center;Medical Informatics;medical schools;medical specialties;Mental Health Services;Mentors;Minority;Mission;multimodality;Neurology;New England;next generation;operation;Opioid;Pain;Pain management;Pain Research;Patient Care;Patient-Centered Care;Primary Care;programs;Reproductive Health;Research;Research Methodology;Research Personnel;sex;Strategic Planning;success;Suicide;Suicide prevention;System;Technology;Training;Veterans;Woman;Women's Health;Women's Health Services

PROJECT_TITLE: Pain, Research, Informatics, Multimorbidities, Education


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: The VA HSR&D Center for the Study of Healthcare Innovation, Implementation & Policy (CSHIIP) has had a fundamental role in the ongoing transformation of VA health care, through critical examination of multilevel determinants of variations in VA care, development and testing of innovative healthcare delivery models that improve the effectiveness and value of VA care, and impact on VA practice and policy through implementation and spread of evidence-based practice. Our work is anchored in a longstanding history of high-impact research through career development, support, and engagement of a multidisciplinary cadre of investigators, leveraging extensive partnerships that have infused our mission, vision, and values with a deep understanding of VA priorities. These partnerships and priorities have guided our strategic planning, enabling us to build a portfolio of highly responsive research in key focused (primary care, women’s health, high-risk/high-need groups) and emerging areas (complementary/integrative health, specialty care, and emergency management).

PI_NAMEs: YANO, ELIZABETH M (contact)

PROJECT_TERMS: Academy;Acceleration;acute care;Adoption;Affect;Area;care coordination;care delivery;career development;Caring;Collaborations;Communication;Complementary Health;Comprehensive Health Care;Development;Disasters;Discipline of Nursing;Dissemination and Implementation;Doctor of Philosophy;Effectiveness;Emergency Situation;Employee;Employee Engagement;Evaluation;evidence base;Evidence based practice;experience;Funding;Gender;Goals;harassment;Health;Health system;Healthcare;high risk;Home;Homelessness;Homogeneously Staining Region;implementation science;improved;innovation;Integrative Medicine;Intervention;Leadership;Los Angeles;Medical;Medical center;medical schools;medical specialties;Medicine;Mentors;Methodology;Methods;Mission;Modeling;multidisciplinary;Neighborhoods;novel;older adult;operation;Outcome;Paper;Patients;Policies;Primary Care;Provider;provider behavior;Public Health;Publishing;Quality of Care;Readiness;Recording of previous events;recruit;Research;Research Personnel;resilience;Role;Safety;scale up;Scientific Advances and Accomplishments;Service delivery model;Services;severe mental illness;Site;Strategic Planning;substance use;System;Testing;tool;Training;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Veterans;Vision;whole health;Woman;Women's Health;Women's Health Services;Work;Workplace


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of the Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) is to enhance the Veterans Health Administration's (VHA) ability to continually improve health care and optimize Veteran wellbeing and independence. ADAPT will lead innovative research on promoting and sustaining healthy lifestyles, improving access through virtual care, and optimizing Veteran function and independence. Working closely with VA and non-VA partners, ADAPT investigators will apply and advance state-of-the-art methods, translate research findings into meaningful practice change, and train the next generation of VA researchers. ADAPT will play a vital role in helping VHA meet the challenges of providing timely, coordinated, consistently high-quality care to more than 9 million Veterans each year.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Area;Behavior;burden of illness;care systems;career development;Caring;Clinical;clinical care;Collaborations;Communities;Data Sources;design;Development;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Ensure;experience;Face;Family;Fostering;Funding;Goals;Grant;Health behavior;health care availability;health care service organization;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation research;Improve Access;improved;Individual;innovation;Lead;Leadership;Life;Long-Term Care;Mentorship;Methods;Modeling;Names;next generation;novel;Observational Study;Personal Satisfaction;Phase;Physicians;Pilot Projects;Play;Policies;Postdoctoral Fellow;Pragmatic clinical trial;Process;Quality of Care;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;research study;resilience;Resources;Role;routine practice;Science;social factors;Time;Training;Translating;Translations;Veterans;Veterans Health Administration;virtual healthcare;Work;World Health Organization


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The Veterans Health Administration (VA) provides care for individuals who are more likely to be racial and ethnic minorities, older, and poorer than the general population. Although VA provides a health care safety net, disparities in health and health care exist for many vulnerable Veteran populations and are associated with increased risks of disability, illness, and death. In addition to individual, provider, and health system factors, disparities may originate outside of the health care system and involve personal behaviors and social and community influences. As a health system committed to delivering high-quality, equitable care to all Veterans, VA must identify vulnerable populations, understand the root causes of disparities, and assess interventions to eliminate them. The Center for Health Equity Research and Promotion's mission is to advance the quality and equity of health and health care for vulnerable Veterans.

PI_NAMEs: FINE, MICHAEL JONAH (contact);LONG, JUDITH A

PROJECT_TERMS: Address;behavioral economics;Big Data;Caring;Cessation of life;Clinical;clinical care;clinical epidemiology;Clinical Trials;Collaborations;Communities;community advisory board;Community Healthcare;Data Analyses;Decision Analysis;design;Development;disability risk;Discipline;Disparity;Ensure;Equity;ethnic minority;General Population;Genomics;Goals;Health;Health behavior change;health disparity;health equity;Health equity research;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;medical specialties;medication safety;Mentors;Meta-Analysis;Methods;military veteran;Mission;Outcome;Pattern;Pennsylvania;Personal Behavior;Pharmacologic Substance;pharmacy benefit;Policies;Program Development;programs;Provider;Psychometrics;Publications;Qualitative Research;racial minority;Records;Research;Research Personnel;Research Training;Safety;safety net;Scientific Advances and Accomplishments;Services;Site;social;Technology Assessment;Therapeutic;tool;Training;Training and Education;Translating;Universities;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Center for Health Equity Research and Promotion (CHERP)


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Given Veterans' increasing choices about where and how they receive care, successful coordination of care will require improving effective communication among a variety of individuals and entities, as well as improved management and use of health information. This project supports the Center for Health Information and Communication, of the U.S. Department of Veterans Affairs Health Services Research & Development Service. The Center's mission is to improve Veterans' health care through innovative research on health information, technology, and communication. The Center's vision is to improve Veterans' health through innovative applications of health information and health information systems that serve the population-based and interpersonal needs of patients and health professionals. The Center will generate knowledge about the impact of the Department's investment in health information technology, and will determine how systems-based and interpersonal communication of health information can improve delivery and outcomes of care.

PI_NAMEs: WEINER, MICHAEL  (contact)

PROJECT_TERMS: Address;alternative treatment;Area;cancer care;care coordination;care outcomes;career development;Caregivers;Caring;chronic pain;chronic pain management;Clinical;clinical decision support;clinical practice;Communication;Communities;computer human interaction;connected care;Decision Making;Dissemination and Implementation;Documentation;Electronic Health Record;Foundations;Funding;Goals;Health;health application;health communication;Health Information System;health information technology;Health Professional;Health Sciences;Health Services Research;Health Technology;Healthcare;improved;Individual;Information Management;innovation;Investments;Knowledge;Mediation;Mental disorders;Mental Health;Mentors;Mission;Office Management;operation;Opioid;Outcome;Pain management;Patients;person centered;Personal Communication;Pharmaceutical Preparations;Policies;population based;Positioning Attribute;programs;Provider;Publications;Research;research and development;Safety;Science;Scientist;Services;skills;Stroke;System;Technology;tool;Translations;Veterans;Veterans Health Administration;virtual;Vision;Work


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The Center for Healthcare Organization and Implementation Research has a mission to conduct organizationally-partnered, and Veteran-partnered research in order to develop, implement, and evaluate evidence-based and innovative practices that improve Veterans Health Administration (VA) healthcare. Our priority goals are: (1) to advance the field of HSR by sustaining, developing, and growing our existing, scientific focus areas, and growing our evolving and emerging scientific areas; (2) to enrich VA's cadre of world-class HSR investigators, by supporting training and education across the career spectrum; and (3) to grow and support innovation in order to maintain VA at the cutting edge of HSR and adapt to meet VA's ever- changing needs.

PI_NAMEs: BOKHOUR, BARBARA G.;GIFFORD, ALLEN L (contact)

PROJECT_TERMS: Address;Adherence;Adverse event;Area;Behavioral;Boston;care coordination;care systems;career;career development;Caring;Collaborations;Communication;community living;connected care;Decision Making;Development;Diffusion of Innovation;Educational process of instructing;Elderly;Elements;Environment;evidence base;Face;Future;Geriatrics;Germination;Goals;health care service organization;Health Service Area;Health Services Administration;Health Services Research;Healthcare;Homelessness;implementation research;improved;Incubators;innovation;International;Justice;K-Series Research Career Programs;Long-Term Care;Long-Term Care for Elderly;Measurement;Measures;Medication Management;Mental Health;Mentors;Mission;Modeling;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Postdoctoral Fellow;Primary Care;Process;programs;Recovery;Research;Research Personnel;Resources;Safety;Scientist;Standardization;success;Suicide prevention;Surgeon;System;team-based care;Technology;Testing;Training and Education;Training Support;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Vulnerable Populations;whole health;Work


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Not applicable

PI_NAMEs: KERR, EVE A (contact)

PROJECT_TERMS: Achievement;Adverse event;Alcohols;Area;Award;behavioral economics;Cannabis;care coordination;care delivery;career;Caring;Chronic;Cladribine;Clinical;clinical center;Clinical Management;Collaborations;Communities;Community Healthcare;Complex;Critical Illness;Data Collection;Development;digital data;Disease Progression;disorder prevention;Effectiveness;experience;Family;Funding;Future;Health;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;high risk;Homogeneously Staining Region;Hospitalization;implementation research;improved;Infrastructure;innovation;Inpatients;Intervention;investigator training;Knowledge;Measurement;Measures;Mental Health;mHealth;Michigan;Mission;Modernization;multidisciplinary;opioid misuse;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;peer support;Performance;Physicians;Play;predictive modeling;Prevention;Primary Care Physician;Productivity;programs;Reporting;Research;Research Infrastructure;Research Personnel;Role;Safety;Scientist;screening;Services;square foot;suicidal risk;Suicide prevention;System;Technology;theories;tool;Training;United States National Institutes of Health;Veterans;Vision;Wages

PROJECT_TITLE: Ann Arbor COIN Renewal Application


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Not applicable.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Area;career development;Caring;Collaborations;Decision Making;Dissemination and Implementation;empowerment;Ensure;experience;Faculty;falls;Family;Feedback;Fellowship;Goals;Health;Health Services Research;Healthcare;Healthcare Systems;improved;innovation;Malignant neoplasm of lung;member;Mental Health;Methodology;Mission;non-opioid analgesic;operation;Opioid;Oregon;Pain;Pain management;Patient-Centered Care;Personal Satisfaction;prescription opioid;Process;Research;Research Methodology;Research Personnel;Safety;Science;Self Care;Site;Substance Use Disorder;Suicide prevention;Support System;Technology;Universities;Veterans;whole health

PROJECT_TITLE: Center to Improve Veteran Involvement in Care (CIVIC)


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation will conduct research to advance scientific discovery, implement novel interventions, promote cross-center collaboration, increase research capacity, and engage operational partners to improve Veteran health. Our research will focus on the public health threat of antibiotic resistance, on mitigating health risks in Veterans during periods of vulnerability, and on improving medication safety as the Department of Veterans Affairs (VA) transitions to a new electronic health record. Across all of these areas, we study methods to promote the adoption of research findings into clinical practice. In the process, we train the next generation of outstanding VA health services researchers. Veteran and stakeholder engagement is a topmost priority for our Center. All of our research is highly collaborative and integrated with clinical programs.

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TERMS: addiction;Adoption;adverse outcome;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;biomedical informatics;Caring;Cities;Clinical;Clinical Investigator;clinical practice;Cognitive;Collaborations;Community Healthcare;Coupled;Data;Decision Making;Decision Support Systems;design;Discipline;Electronic Health Record;Ensure;Environment;Event;Goals;Guidelines;hazard;Health;health care delivery;health information technology;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;implementation science;improved;Infection prevention;Informatics;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Link;medication safety;Medicine;Mental Health;Methodology;Methods;Military Personnel;Modernization;Natural Language Processing;Nature;next generation;novel;Overdose;patient safety;Pharmacoepidemiology;Population;prediction algorithm;Process;programs;Public Health;Qualitative Research;recruit;Research;Research Activity;Research Personnel;Risk;Rural Health;Safety;Science;Scientific Advances and Accomplishments;simulation;Sodium Chloride;Source;stakeholder perspectives;Statistical Models;success;suicidal;System;Therapeutic;tool;Training;Translational Research;Traumatic Brain Injury;Trust;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vision;Visualization

PROJECT_TITLE: IDEAS 3.0


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The Center for Mental Healthcare & Outcomes Research (CeMHOR) is an HSR&D Center of Innovation whose mission is to optimize health and well-being of Veterans through innovative research to improve access to and engagement in evidence-based care for mental health and substance use disorders and prevent suicide. CeMHOR accomplishes its mission by partnering directly with Veterans, clinical leaders, and front-line providers to develop feasible and effective interventions to address top VA and national priorities. CeMHOR expertise in implementation science leads to widespread uptake of these interventions. CeMHOR investigators are also experts in rural health and community engagement. CeMHOR research will apply this expertise to include Veterans who are not receiving VA care, as well as those who use VA services but do not fully engage in needed care. In addition to two focus areas, mental health care access/engagement and suicide prevention, investigators conduct research to address opioid misuse and abuse and advance implementation science.

PI_NAMEs: OWEN, RICHARD R. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;American;Area;Arkansas;Awareness;behavioral health;career development;Caring;clay;Clergy;Clinical;Collaborations;Communities;community college;community engagement;Community Outreach;community setting;Demographer;design;Development;effective intervention;Effectiveness;Epidemiologist;Evaluation;evidence base;Federally Qualified Health Center;gaps in access;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare Systems;implementation intervention;implementation science;Improve Access;improved;innovation;Intervention;Knowledge;Location;Managed Care;Medical;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Methods;Mind;Mission;Modeling;opioid abuse;opioid misuse;opioid use disorder;Outcomes Research;peer support;Personal Satisfaction;Pharmacists;Prevention;Prevention strategy;Primary Care;Professional counselor;programs;Provider;Psychiatrist;Psychologist;Research;Research Personnel;Resources;Risk;Rural;rural area;Rural Community;Rural Health;Science;Services;Social Workers;sociologist;Substance Use Disorder;Suicide prevention;Testing;Training;Translating;Universities;uptake;Veterans;virtual healthcare;Work


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care has had outstanding productivity and impact on Veteran healthcare and well-being through the application of the National Academy of Medicine's learning health system. In the past 3 years, our 47 investigators generated ~$47 million in operating revenue, published 583 manuscripts, and led 113 projects across our research, implementation science, operational projects/program evaluations and training programs. Our dual-site Center will continue to address our two focus areas: 1) promote Veteran-centered care to improve patient experiences across VA healthcare and community settings and 2) advanced value-driven care by providing Veterans the highest quality care at the lowest financial burden. Building on our prior success, we will continue to partner with operational leaders and our Veteran Engagement Board to innovate new research, implementation science, and operational programs as well as train the next generation of outstanding research leaders.

PI_NAMEs: AU, DAVID H (contact);HO, P. MICHAEL

PROJECT_TERMS: Academy;Address;Area;Award;care delivery;career development;Caring;clinical care;Colorado;Communities;community setting;Complex;Congresses;Deimplementation;disparity elimination;Evaluation;experience;Faculty;Financial Hardship;Funding;geographic disparity;health care service;health care settings;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;improved outcome;innovation;Intervention;Knowledge;Lead;Learning;Manuscripts;Medical center;medical specialties;Medicine;Mental Health Services;Methods;Mission;next generation;novel strategies;Paper;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Policies;Postdoctoral Fellow;Primary Care;primary health service;Productivity;Program Evaluation;programs;Provider;Psyche structure;Publishing;Quality of Care;Research;research clinical testing;Research Personnel;Rural Health;Safety;satisfaction;Self Management;Site;socioeconomic disparity;sound;Statutes and Laws;success;Suicide prevention;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Veterans;Washington;Women's Health;Work;Workforce Development

PROJECT_TITLE: Seattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care


PHR: Center for Innovation to Implementation (Ci2i)'s mission is to foster high-value health care for Veterans within and beyond VA. We do so by identifying opportunities to improve value and then testing the implementation of innovations that respond to those opportunities. We have organized our work in fostering value within a learning health care system around three foci: 1) mental health care, 2) medical and surgical specialty care and 3) care beyond the VA.

PROJECT_TERMS: Abbreviations;Academy;Acceleration;acronyms;Address;Area;Award;care providers;career development;caregiving;Caring;Clinical;Collaborations;Communication;Communities;Community Services;Complex;cost;Dissemination and Implementation;Ensure;Environment;Evaluation;Fostering;Funding;Future;Grant;Health;health care delivery;health economics;Health Services;Health Services Research;Healthcare;Healthcare Systems;high risk;Home;implementation efforts;implementation science;Improve Access;improved;Infrastructure;innovation;Institution;International;Leadership;Learning;Maps;Measures;Medical Care Costs;Medical center;medical specialties;Medicine;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;Methods;Mission;Monitor;novel strategies;operation;organizational structure;Outcome;Paper;Patient-Centered Care;Patients;Performance;Physicians;Policies;Policy Maker;Post-Traumatic Stress Disorders;Process;Provider;Publishing;Quality of Care;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Resource Allocation;Resources;Role;Services;Silicon;social;Social Work;Specialist;Substance Use Disorder;success;Suicide prevention;Surgical Specialties;System;Testing;theories;Time;Training and Education;Veterans;Vision;Visit;Work

PROJECT_TITLE: Center for innovation to implementation


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: The Houston Health Services Research & Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (IQuESt) has been continuously funded by HSR&D since 1990, providing strong scientific leadership and institutional infrastructure dedicated to a model of embedded health system research. We have a nearly 20-year tradition of conducting research in partnership with the health care delivery system and responding to its needs, making us pioneers in the execution of the learning health care system model in VHA. The IQuESt mission, “Improving health and well-being through innovations in health care delivery”, conveys our commitment to transformative and innovative research that is aligned with VHA national priorities. IQuESt is ideally poised to contribute to making care more accessible, safer, and more patient-centered with innovative research, rapid implementation of evidence, novel methodologies, solid partnerships, stakeholder engagement, career development of scientists, and infrastructure to promote the learning health care system in VHA.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: Biological Models;career development;Caring;Dedications;Effectiveness;Funding;Health;health care delivery;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Leadership;Learning;Methodology;Mission;Modeling;novel;patient oriented;Personal Satisfaction;Research;research and development;Safety;Scientist;Solid;System;systems research

PROJECT_TITLE: Center for Innovations in Quality, Effectiveness, and Safety (IQuESt)


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: There is a pressing need to examine value, defined as health outcomes achieved per dollar spent. Heart failure (HF) is a common illness among Veterans with frequent hospitalizations and significant mortality and costs occurring and accruing after hospital discharge. We will examine variation in home time, defined as time spent alive and outside of health care institutions, and costs across VA facilities during HF care episodes over a 90-day period. We will then identify practices and factors underlying the variation. We will then pilot-test using key strategies to implement an intervention consisting of the identified practices and accounting for the identified factors. This implementation and intervention may then be used for all Veterans with HF discharged from VA hospitals. This proposal supports the vision of current VA leadership to improve health care value and test implementation strategies to support care coordination. The proposed work, with appropriate guidance and training, will foster the career development of Paul L. Hess, MD, MHS, to improving VA health care value.

PI_NAMEs: HESS, PAUL LAURENCE (contact)

PROJECT_TERMS: Academy;Accounting;Admission activity;Adoption;Affect;American;American Heart Association;Appointment;Cardiology;care coordination;care costs;care delivery;care episode;career development;Caring;Chronic Disease;Clinical;cohort;college;Complement;Complex;Consolidated Framework for Implementation Research;cost;Data;Death Rate;Disease;Dissemination and Implementation;dissemination science;Education;effectiveness/implementation trial;Eligibility Determination;evidence base;Evidence based intervention;Evidence based practice;Feedback;follow-up;Fostering;Goals;Guidelines;Health;health economics;Healthcare;Healthcare Systems;Heart failure;Home;hospital readmission;Hospitalization;Hospitals;implementation design;implementation intervention;implementation science;implementation strategy;improved;indexing;Individual;informant;innovation;Institution;Intervention;Interview;Leadership;Measurement;Medicine;Mentorship;Methodology;Methods;mortality;novel;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;pilot test;Policy Maker;Process;Provider;Quality of Care;Recommendation;Risk;Risk Adjustment;Self Management;skills;social organization;Specific qualifier value;Standardization;Testing;theories;Time;Training;United States Department of Veterans Affairs;uptake;Variant;Veterans;Veterans Health Administration;Vision;Work

PROJECT_TITLE: Designing for Implementation and Dissemination of High-Value Heart Failure Transitional Care

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Harassment of women Veterans is a recognized problem in VA facilities. Harassment can negatively impact women Veterans’ perceptions of safety and comfort, generate feelings of fear and/or anxiety, or for women with trauma histories, trigger trauma-related memories and symptoms. This, in turn, can contribute to avoidance of or reduced use of VA care, placing women at greater risk for poorer health outcomes. However, currently there are no interventions to address harassment in healthcare settings. The proposed study aims: 1) to create a bystander intervention to address gender-based harassment using photonarratives developed using Photovoice participatory action research methods and bystander intervention education adapted for VA; and 2) to assess if the intervention is feasible, acceptable, and if it increases awareness of harassment as well as its impacts and attitudes towards and confidence in one’s ability to engage in behaviors to address harassment.

PI_NAMEs: DRAPALSKI, AMY L (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;Address;Anxiety;Attitude;Awareness;Behavior;Caring;Charge;Collaborations;college;Communities;community based participatory research;Comprehensive Health Care;Data;Development;disparity reduction;Educational Intervention;Educational Materials;efficacy evaluation;Ensure;Evidence based intervention;experience;Feedback;Feeling;Female;Focus Groups;Fright;future implementation;Gender;Goals;harassment;health care settings;Health Services Administration;high school;implementation intervention;Individual;innovation;Intervention;intervention program;intervention refinement;Intervention Trial;Interview;Knowledge;Leadership;male;meetings;member;Memory;Methodology;Methods;Military Personnel;Modeling;novel;Outcome;Participant;peer;Perception;pilot test;pilot trial;poor health outcome;post intervention;prevent;Privacy;programs;Provider;Published Comment;Quality of Care;randomized trial;Recording of previous events;recruit;Reporting;Research Methodology;Resources;Risk;Safety;Security;Self Efficacy;Services;Sexual Harassment;sexual violence;Sexual violence prevention;Social Marketing;Symptoms;System;Training;Trauma;Veterans;Veterans Health Administration;willingness;Woman;Women's Health;Women's Health Services;Women's study

PROJECT_TITLE: Bystander Activation Intervention to Address Gender-Based Harassment

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

ORG_STATE: NY

PHR: In 2007, Veterans Health Administration (VHA) created a Veterans Crisis Line (VCL) as a 24-hour point of contact for Veterans who are at high-risk for suicide. Despite high use, there is a critical need to examine the impact of emergency dispatches (i.e., 911) because of the potential life-saving benefits and possible negative consequences. Emergency intervention could be viewed as intrusive or problematic by Veterans who did not agree to it; thus, predicting negative outcomes. We are proposing a multi-method examination of VCL emergency dispatches among Veteran callers. Quantitative analyses will be used to examine key correlates (i.e., call and caller characteristics) of emergency dispatches and agreement to the dispatch, and their prospective associations with treatment engagement and suicide outcomes (i.e., deaths and attempts). Qualitative interviews will be used to understand Veteran and responder emergency dispatch experiences to evaluate the ecological validity of the quantitative findings and inform policy and research.

PI_NAMEs: BRITTON, PETER C (contact)

PROJECT_TERMS: Aftercare;Agreement;Awareness;Caring;Cessation of life;Characteristics;Data;Databases;design;emergency service responder;Emergency Situation;empowerment;Evaluation;experience;Health Services Research;high risk;Homogeneously Staining Region;Hour;improved;innovation;Intervention;Interview;Leadership;Life;Link;Measurement;Measures;Methodology;Methods;novel;Outcome;Policies;Procedures;prospective;Research;Risk;Site;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Training;United States Department of Veterans Affairs;Veterans;Veterans Health Administration

PROJECT_TITLE: A Multi-Method Examination of Veteran Crisis Line Emergency Dispatches

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


PHR: Female Veterans are twice as likely to die by suicide, compared to female non-Veterans, and most commonly use firearms as their method of suicide. Lethal means safety (LMS; i.e., temporarily reducing access to lethal means) is recommended to prevent suicide. However, efforts primarily focus on male Veterans, whose firearm experiences and needs differ from female Veterans. LMS for female Veterans likely requires a systemic approach involving partners and providers. This study will: (1) describe female Veterans’ experiences, perspectives, and preferences regarding firearm LMS; (2) explore female Veterans’ partners’ perspectives and willingness to engage in firearm LMS; (3) understand VHA mental health (MH) and primary care (PC) providers’ perspectives and experiences of firearm LMS with female Veterans. Qualitative interviews will be conducted with female Veterans who have experienced suicidal ideation or attempt, female Veterans’ partners or spouses, and VHA MH and PC providers to inform a patient-centered, gender-sensitive approach to preventing firearm suicide.

PI_NAMEs: MONTEITH, LINDSEY LIH (contact)

PROJECT_TERMS: Address;Age;Behavior;Belief;Caring;Cessation of life;comorbidity;Congresses;Counseling;Data;Development;empowerment;Ensure;experience;Family member;Feeling suicidal;Female;firearm access;Firearms;Gender;Health Personnel;Household;Individual;innovation;Interpersonal Violence;Intervention;intervention refinement;Intervention Studies;Interview;intimate partner violence;Knowledge;lens;Location;male;Medical;Mental Health;Mental Health Services;Methods;operation;Ownership;patient oriented;patient population;Population;Population Intervention;preference;prevent;Prevention program;Prevention Research;Prevention strategy;Primary Care;primary care practice;primary care provider;Process;Provider;provider behavior;Qualitative Methods;Recommendation;Recording of previous events;Reporting;Research;Resources;Role;Safety;sexual assault;Spouses;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Theoretical model;therapy development;Trauma;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;willingness;Woman;Women's Health;Work

PROJECT_TITLE: Perspectives of Female Veterans, VHA Providers, and Family Members on Preventing Firearm-Inflicted Suicides among Female Veterans


PHR: Acute and chronic inflammation contributes significantly to poor health, most notably as a risk factor for the development of atherosclerotic vascular disease and its complications, such as heart attacks, strokes, and limb ischemia that are substantial causes of morbidity and mortality in veterans. Evidence from preclinical studies and a recent large clinical trial suggest that targeting inflammation can reduce arterial thrombosis and myocardial infarction. However, the precise mechanism(s) that link inflammation to thrombosis remain unknown. In this proposal, we will test the hypothesis that the acute phase reactant serum amyloid A plays a novel role in accelerating thrombosis through a direct effect on platelet function. We will define the signaling pathways involved and their contributions to thromboinflammatory conditions using preclinical models. Our work could define a unique signaling pathway that links inflammation to thrombosis and may suggest innovative targets to prevent devastating cardiovascular complications.

PI_NAMEs: MORRIS, ANDREW J (contact);SMYTH, SUSAN S.

PROJECT_TERMS: Acceleration;Acute;acute coronary syndrome;Acute-Phase Proteins;Address;Adhesives;Agonist;Amyloid;Animal Model;Arterial Injury;Atherosclerosis;Biochemical;Biological Models;Biology;Blood Platelets;C-reactive protein;Cardiovascular Diseases;Cardiovascular system;Chronic;Clinical Trials;Collaborations;Creativeness;Cues;Data;Development;Diagnosis;disability;Event;Experimental Models;Future;Genetic;Goals;Grant;Health;Healthcare Systems;Hemostatic function;Human;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;innovation;Intervention;Knowledge;Leukocytes;limb ischemia;Link;Literature;loss of function;Mediating;Mediator;Medical Care Costs;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;myocardial injury;novel;overexpression;P-Selectin;Pathologic;Pathway interactions;Patients;pharmacologic;Physiological;Plasma;Platelet Activation;Platelet aggregation;platelet function;Play;Pre-Clinical Model;preclinical study;prevent;preventable death;Prevention;Reagent;Research;Research Personnel;Resources;response;response to injury;Risk Factors;Role;Serum;Serum amyloid A protein;Signal Pathway;Signal Transduction;Stroke;synergism;systemic inflammatory response;Techniques;Testing;thromboinflammation;Thrombosis;tissue injury;transmission process;treatment strategy;vascular injury;Veterans;Work

PROJECT_TITLE: Serum Amyloid as a Critical mediator between inflammation and thrombosis


PHR: Eating disorders (EDs) are pernicious conditions with the highest mortality rate of any psychiatric disorder. Gaps in our knowledge regarding the prevalence of EDs in male and female Veterans, what healthcare services are being used by Veterans with EDs and what services Veterans with EDs would like to use if offered in the VA, the impact of military sexual trauma and combat exposure on the development of EDs, validity of ED screening measures, and Veteran preferences for screening limit VA's ability to respond to the needs of Veterans with EDs. EDs disproportionately affect women, and female Veterans are the fastest growing segment of Veterans Health Administration (VHA), underscoring the need for examination of EDs and gender similarities/differences. Our findings will provide important information regarding the scope of the problem of EDs and inform approaches for targeted screening within VA. This proposal addresses an important gap in caring for Veterans with EDs. Findings will be highly relevant to VHA clinical leaders and policy makers. !

PI_NAMEs: MITCHELL, KAREN SUZANNE (contact)

PROJECT_TERMS: Address;Affect;Anorexia Nervosa;Anxiety;Area;Binge Eating;Binge eating disorder;Bulimia;Caring;Clinical;cohort;combat;combat trauma;Communities;Comprehensive Health Care;Data;Death Rate;Dedications;Department of Defense;Development;Diagnosis;Disease;Disproportionately impacts women;Eating Disorders;Equation;Ethnic Origin;experience;Exposure to;Family;Female;Gender;General Population;Generations;Guidelines;health care service;health care service utilization;Healthcare;Impairment;Individual;individualized medicine;Knowledge;Leadership;male;Measures;Medical;medical appointment;men;Mental Depression;Mental disorders;Methods;Military Personnel;military veteran;Modeling;Newsletter;older adult;older men;Overweight;Participant;Patients;Policy Maker;Post-Traumatic Stress Disorders;preference;Prevalence;Procedures;programs;protective factors;Provider;Psychotic Disorders;Race;Random Allocation;Recommendation;Records;recruit;Reporting;repository;Research;resilience;Resources;Risk;Risk Factors;ROC Curve;Roundup;Sampling;screening;screening program;Sensitivity and Specificity;Services;sexual trauma;statistics;Subgroup;Substance Use Disorder;Surveys;Symptoms;Time;Training;Trauma;trauma exposure;treatment services;Veterans;Veterans Health Administration;Woman;Women's Health;Women's prevalence;Work

PROJECT_TITLE: Eating disorders in Veterans: Risk, resilience, and service use


PHR: This project will fill several critical gaps in the area of suicide research by developing methods to identify sexual minority status, suicide attempts and completed suicide using data from the Veterans Administration (VA), the nation's largest integrated healthcare system. We will examine whether there is variation in suicide risk and protective factors among LGBT and other Veterans in VA care, with emphasis on mental health and substance use disorders, pain, and use of complementary health approaches such as acupuncture, which may help to reduce suicidality. Results have important public health implications, and the methodology may be adapted to expand our understanding and promote outreach to all individuals at risk for suicide both within and outside VA.

PI_NAMEs: GOULET, JOSEPH LUCIEN (contact);ZENG, QING

PROJECT_TERMS: Achievement;Acupuncture Therapy;Address;Aftercare;age group;American;Area;Attenuated;Awareness;care outcomes;Caring;Cessation of life;Clinical;cohort;Coin;comorbidity;Complementary Health;completed suicide;Data;data repository;database structure;Diagnosis;Discrimination;Disease;Distal;Electronic Health Record;Enrollment;Ensure;Ethnic Origin;Ethnic Population;Event;Gays;Gender;Gender Identity;Gender identity disorder;Goals;health service use;Health Services;Health Services Research;High Prevalence;Homelessness;Homogeneously Staining Region;Hospital Administration;Human Resources;indexing;Individual;infancy;informatics tool;Integrated Health Care Systems;Integrative Medicine;Lesbian;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Letters;LGBT Health;Literature;Longitudinal cohort;Machine Learning;Medical;Mental Health;Methodology;Methods;Military Personnel;military veteran;Minority;minority stress;Morbidity - disease rate;musculoskeletal disorder diagnosis;Natural Language Processing;Opioid;Outcome;outreach;Pain;Pathway interactions;Patient Self-Report;Patients;Persons;Policies;Population;Post-Traumatic Stress Disorders;Predisposing Factor;prescription opioid;Prevalence;programs;protective factors;Provider;Public Health;Race;racial population;reducing suicide;Research;Research Personnel;Risk;Risk Factors;rural setting;Sampling;satisfaction;Services;sex;Sex Orientation;sexual minority status;sexual trauma;social health determinants;social stigma;Stress;Structure;structured data;Substance abuse problem;Substance Use Disorder;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;Time;tool;transgender;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;urban setting;Variant;Veterans;Veterans Health Administration;Woman;Work;Youth

PROJECT_TITLE: Understanding Suicide Risks among LGBT Veterans in VA Care


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: The rate of suicide among women Veterans has grown in recent years and is significantly higher than that of women who have not served in the military. The Veterans Crisis Line (VCL) is a VA suicide prevention initiative that connects Veterans in crisis, as well as concerned family or friends, with supportive resources to prevent suicide. The purpose of this study is to identify the characteristics of women Veteran VCL users and how they compare to male Veteran VCL users, identify the relationship between VCL contact characteristics suicide- related outcomes among male and female Veteran VCL users, and identify the experiences and recommendations of women Veteran VCL users. Through analysis of administrative clinical data and in-depth interviews with women Veteran VCL users, along with input from a multi-stakeholder advisory board, this research will serve to develop clinical recommendations and implementation strategies to strengthen suicide prevention initiatives specifically for vulnerable populations of women Veterans.

PI_NAMEs: DICHTER, MELISSA E (contact)

PROJECT_TERMS: Acute;Address;Area;Caring;Characteristics;Clinical;Clinical Data;Collaborations;Crisis Intervention;Data;data repository;Economics;Eligibility Determination;Enrollment;Evaluation;expectation;experience;Family;Feeling;Feeling suicidal;Female;follow-up;Friends;Gender;gender difference;Health;health record;Health Services Administration;Health Services Research;help-seeking behavior;High Risk Woman;Hotlines;Hour;Housing;housing instability;implementation strategy;improved;innovation;Interpersonal Violence;Interview;Investigation;Investments;Knowledge;Left;male;Medical Records;men;Mental Health;Methodology;Methods;Military Personnel;operation;Outcome;Patients;Policies;Population;prevent;Prevention;Prevention Research;prevention service;programs;Recommendation;Research;Research Priority;Resolution;Resources;Risk;Sampling;Self Direction;service intervention;service utilization;Services;Severities;social;Social Characteristics;Social isolation;social relationships;Statistical Data Interpretation;Structure;suicidal;suicidal behavior;suicidal risk;suicidal women;Suicide;Suicide attempt;Suicide prevention;suicide rate;Telephone;Telephone Interviews;Text Messaging;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Violence;Vulnerable Populations;Woman;Women's Health;women's outcomes;Work;young woman

PROJECT_TITLE: Strengthening Suicide Prevention Efforts for Women Veterans through the Veterans Crisis Line


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Neurosciences;Prevention;Rehabilitation;Sleep Research;Stroke

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Obstructive sleep apnea (OSA) is a treatable illness that affects the majority of stroke patients and predicts poor outcomes after stroke, including mortality, functional outcome, and recurrent stroke. Leveraging the infrastructure of StrokeNet, we propose a phase III multicenter, prospective randomized open-, blinded- endpoint controlled trial of positive airway pressure for stroke recovery and prevention in stroke patients with OSA.

PI_NAMEs: BROWN, DEVIN L (contact);CHERVIN, RONALD D

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acute;acute coronary syndrome;acute stroke;Address;Adherence;Affect;airway obstruction;American Stroke Association;Biomedical Technology;Blinded;Blood Vessels;Cardiopulmonary;Caring;Coagulation Process;Cognitive;community setting;comparative;Continuous Positive Airway Pressure;cost;cost effective;cost effective intervention;Cost Savings;Country;Data;design;Devices;Diagnosis;Diagnostic;digital technology;Eligibility Determination;Event;experience;Foundations;functional outcomes;Goals;high risk;Home;Hospitalization;Hospitals;Hour;Hypoxemia;implementation facilitation;improved;Infrastructure;innovation;insight;Intervention;Investigation;Ischemic Stroke;Location;Managed Care;Mechanics;Methods;Monitor;mortality;Neurologic;novel;novel therapeutics;Observational Study;Obstructive Sleep Apnea;open label;Outcome;Patients;Phase;Physiological;pilot trial;Polysomnography;Population;portability;Positioning Attribute;positive airway pressure;post stroke;pragmatic trial;prevent;Prevention;Prevention Guidelines;Prevention trial;primary outcome;prospective;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Recurrence;Research Design;Research Personnel;Resources;Retrieval;Risk;Risk Factors;Role;Safety;Secondary Prevention;Sleep;Sleep Apnea Syndromes;Stroke;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke risk;Sympathetic Nervous System;Testing;Therapeutic Intervention;Thrombectomy;thrombolysis;Time;Titrations;Transient Ischemic Attack;Translating;treatment as usual;trial design;Work

PROJECT_TITLE: Sleep for Stroke Management And Recovery Trial (Sleep SMART)


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Veterans with bipolar disorder (BP) and comorbid substance use disorders (SUDs) have poor treatment adherence and poor clinical outcomes, high rates of suicide, and increased psychiatric hospitalization. They are at particularly high risk for treatment nonadherence when transitioning from psychiatric hospitalization to outpatient care, with little to no treatment options available to improve care of this high-risk population at the critical period following hospital discharge. The current project will test the effectiveness of Integrated Treatment Adherence Program (ITAP), which is the first adjunctive psychosocial program specifically designed to improve treatment adherence and reduce suicidality, bipolar symptoms, and substance use among high-risk patients with BP-SUD. If shown effective, ITAP could be easily and efficiently adopted as standard care for hospitalized Veterans with co-occurring BP and SUD within VHA. Findings from this study will inform clinical and policy efforts on the implementation of BP treatment for Veterans with co-occurring SUD post-discharge.

PI_NAMEs: GAUDIANO, BRANDON A;METRIK, JANE  (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Aftercare;Alcohol consumption;Alcohols;Ambulatory Care;Appointment;Area;Behavior;Behavioral;Bipolar Disorder;Blinded;Caring;Cessation of life;Clinical;comorbidity;contextual factors;critical period;Data;Death Rate;depressive symptoms;design;Disease;Dissemination and Implementation;Dose;Drug usage;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Electronics;Emergency department visit;Evaluation;evidence base;Feeling suicidal;follow-up;formative assessment;Future;future implementation;Gender;Health Care Costs;Health Services;high risk;high risk population;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation efforts;implementation framework;Implementation readiness;implementation strategy;implementation trial;improved;innovation;inpatient psychiatric treatment;inpatient service;Intervention;intervention effect;intervention program;Leadership;Manic;Measures;Mediating;Mediator;medication compliance;Mental Health;Methodology;Monitor;mood symptom;Moods;Opioid;opioid overdose;organizational readiness;Outcome;Participant;Patient Discharge;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;Population;Populations at Risk;Prevalence;preventive intervention;primary outcome;Problem Solving;process evaluation;programs;psychiatric inpatient;psychosocial;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reducing suicide;Relapse;Research;Research Priority;safety assessment;Sampling;scale up;secondary outcome;Severities;Site;skills;Social Workers;standard care;standard of care;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Telephone;Testing;Therapeutic;therapy design;Training;treatment adherence;treatment as usual;treatment effect;Treatment outcome;treatment risk;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Post-Hospital Intervention for Veterans with Comorbid Bipolar and Substance Use Disorders


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Posttraumatic stress disorder (PTSD) afflicts many war Veterans, but often they are reluctant to seek help despite availability of effective treatments. Family members are key sources of support who can help encourage such Veterans to initiate mental health services. Toward that goal, VA provides telephone coaching to family members through its Coaching Into Care (CIC) program to help get their Veterans into care. While CIC enjoys high caller satisfaction, it has shown only modest success getting Veterans into care. Blended interventions that include professional support and technology-based interventions offer promise for improving effectiveness of services. Therefore, this proposal tests an intervention that blends CIC calls with a web program called VA Community Reinforcement and Family Training (VA-CRAFT). VA-CRAFT is a translation of an empirically-validated model intended to help Veterans by training their family members to effectively promote care-seeking. If successful, this approach will support families and help more Veterans receive needed mental health care for PTSD.

PI_NAMEs: KUHN, ERIC ROLAND (contact);SAYERS, STEVEN L.

PROJECT_TERMS: acceptability and feasibility;Address;Advertisements;Advertising;Aftercare;care seeking;care systems;Caregiver Burden;Caring;cohesion;Collaborations;combat veteran;Communities;Conflict (Psychology);Data;Distress;effective therapy;Effectiveness;effectiveness evaluation;efficacious treatment;empowerment;Evidence based treatment;Expectancy;Face;Family;family influence;Family member;family support;follow-up;Friends;Funding;future implementation;Goals;help-seeking behavior;Impairment;improved;improved outcome;Individual;innovation;Internet;Intervention;intervention effect;Interview;Leadership;loved ones;Manuals;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mental Health Services;Methods;military veteran;Modeling;Motivation;Online Systems;Outcome;outreach;Participant;Personal Satisfaction;Population;post intervention;Post-Traumatic Stress Disorders;process evaluation;Program Evaluation;programs;psychological distress;Psychological reinforcement;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;response;satisfaction;Self Efficacy;service utilization;Services;services as usual;social media;Source;Spouses;success;symptomatology;technology intervention;telephone based;telephone coaching;Testing;Training;Translations;treatment as usual;treatment effect;Veterans;Waiting Lists;War;web site;Work

PROJECT_TITLE: A Randomized Controlled Trial of Coaching into Care with VA-CRAFT to Promote Veteran Engagement in PTSD Care


PHR: Suicide is a significant problem for Veterans and those who report sleep difficulties are at higher risk of dying by suicide. The current project will examine the relationship between sleep and suicide using a longitudinal, multimodal assessment protocol. Sleep, suicide thoughts and behaviors, and proposed mechanisms such as emotional reactivity and impulsivity will be assessed regularly. Findings will help clarify the nature of the sleep- suicide relationship and will help identify targets for suicide prevention.

PI_NAMEs: MCGEARY, JOHN E (contact);PRIMACK, JENNIFER MARIE

PROJECT_TERMS: actigraphy;Automobile Driving;Behavior;Cause of Death;comorbidity;Data;design;Development;Devices;diaries;Ecological momentary assessment;emotion regulation;Emotional;Emotions;Environment;Feeling suicidal;follow up assessment;Future;Goals;Growth;high risk;Hospitalization;Hospitals;Hour;improved;Impulsivity;inpatient psychiatric treatment;Inpatients;interest;Laboratories;Linear Regressions;Link;Longitudinal Studies;Measures;Methodology;Military Personnel;Modeling;modifiable risk;Moods;multimodality;Nature;Neurocognitive;Outpatients;Participant;Patient Self-Report;Population;programs;Protocols documentation;Psychiatric therapeutic procedure;recruit;Regulation;Reporting;Research;Risk;Risk Factors;Sampling;Sleep;Sleep Deprivation;sleep difficulty;Sleep Disorders;Sleep disturbances;social;stressor;Structural Models;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Time;United States;Variant;Veterans

PROJECT_TITLE: Longitudinal Assessment of the Sleep-Suicide Link in Veterans Discharged from Inpatient Psychiatric Care


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: Project Narrative This project is for performing a clinical trial of an experimental intracortical visual prosthesis. Targeted for individuals with blindness, the purpose of the prosthesis is to communicate image information captured from a camera directly to the visual cortex of the brain. This will be tested under an Early Feasibility Study, approved by the FDA.

PI_NAMEs: TROYK, PHILIP R (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Accommodation phosphene;Address;Animal Testing;Biological Sciences;biomaterial compatibility;blind;Blindness;Brain;Businesses;Chicago;Clinical;Clinical Protocols;Clinical Trials;Communication;design;Development;Devices;Electric Stimulation;Electrodes;Esthesia;Evaluation;experience;fabrication;FDA approved;Feasibility Studies;feasibility trial;first-in-human;flexibility;Goals;Health;Human;Human Volunteers;Illinois;Image;Implant;implantation;In Vitro;in vivo;Individual;Institution;Institutional Review Boards;Intention;Joints;Laboratories;Lead;Marketing;member;Mental Depression;Methods;Microelectrodes;neural;nonhuman primate;Ocular Prosthesis;Operative Surgical Procedures;Patients;Perception;Persons;Phase;Preparation;Prosthesis;Protocols documentation;psychologic;Psychophysics;Quality of life;research clinical testing;Research Personnel;Safety;Seminal;Sensory;sight restoration;Social isolation;Subjects Selections;System;Technology;Testing;Texas;Universities;usability;Vision;Visual;Visual Cortex;Visual impairment;Visual System;volunteer;wireless;wireless implant;Work

PROJECT_TITLE: Clinical Testing of an Intracortical Visual Prosthesis System


PHR: Chronic insomnia, one of the most common health problems among Veterans, significantly impacts health, function, and quality of life. However, a gap exists between the high prevalence of insomnia and access to the recommended treatment, Cognitive Behavioral Therapy for Insomnia (CBTI), which is often only available in specialty care settings. Brief Behavioral Treatment for Insomnia (BBTI), adapted from CBTI, is effective, brief, flexible, and easy to deliver in the Primary Care setting by embedded mental health clinicians (Primary Care Mental Health Integration [PCMHI]). Yet, simply training PCMHI clinicians to deliver BBTI is rarely enough. Specific strategies are often necessary to ensure that evidence-based practices, like BBTI, are successfully adopted and sustainably delivered. Identifying and applying these strategies to implement BBTI into routine clinical care in VA Primary Care settings, where insomnia is typically first recognized, may effectively and efficiently increase access to care and help decrease the risks and burdens related to chronic insomnia.

PI_NAMEs: BRAMOWETH, ADAM DANIEL (contact)

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;American College of Physicians;Area;Baltimore;Behavior Therapy;Behavioral;care delivery;Caring;Chronic Insomnia;Clinic;Clinical;clinical care;Clinical Trials;Cognitive Therapy;Collaborations;Data;design;Diagnosis;Disease;Education;effectiveness/implementation design;effectiveness/implementation trial;Electronic Health Record;Ensure;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Exposure to;Feedback;flexibility;Frequencies;Funding;Future;Goals;Health;Health Services Accessibility;Health Services Research;Healthcare Systems;High Prevalence;Hybrids;hypnotic;implementation barriers;implementation efforts;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;Improve Access;improved;innovation;interest;Intervention;Interview;K-Series Research Career Programs;Maintenance;Measures;Medical center;medical specialties;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;military veteran;Modeling;operation;Outcome;Patients;Persons;Phase;Philadelphia;physical conditioning;Policies;post implementation;Primary Care;primary care practice;primary care setting;primary outcome;product development;Provider;Psychotherapy;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Research Design;Research Methodology;Risk;Sampling;sedative;Site;Sleeplessness;Stigmatization;success;Suicide prevention;Surveys;Symptoms;telehealth;Testing;Training;Translating;Treatment Effectiveness;Treatment outcome;United States National Institutes of Health;uptake;Veterans;virtual healthcare;Work

PROJECT_TITLE: Enhancing Access to Insomnia Care (EASI Care): Implementing Brief Behavioral Treatment for Insomnia in Primary Care Mental Health Integration Clinics


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Dietary Supplements;Emerging Infectious Diseases;Infectious Diseases;Lung;Natural Products;Nutrition;Palliative Care;Prevention;Pulmonary Fibrosis

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Most deaths from ß-coronavirus-19 in the US are in elderly, chronically-ill nursing home residents from hyper- inflammation, cytokine storm, thrombosis (strokes, heart attacks), and multi-organ failure. Senescent cells that accumulate with aging and chronic disease produce factors that cause inflammation, thrombosis, fibrosis, and impaired resistance to viruses and that promote entry of ß-coronavirus-19 into normal cells. We discovered drugs that ablate senescent cells, senolytics, including the natural product, Fisetin, and found: 1) Fisetin decreases death of old mice infected with ß-coronavirus, 2) Fisetin causes few or no side-effects in frail elderly humans, and 3) senolytics decrease senescent cells and inflammation in humans, so we propose a double- blind, placebo-controlled clinical trial of Fisetin to decrease progression and complications in older nursing home residents who have ß-coronavirus-19 across the multi-center Translational Geroscience Network.

PI_NAMEs: PIGNOLO, ROBERT JOHN (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Ablation;Academic Medical Centers;Acute Respiratory Distress Syndrome;adverse outcome;Age;age related;Aging;Antibody Response;Antigens;Apoptotic;Benefits and Risks;betacoronavirus;Blood;Caring;Categories;Cells;Cessation of life;Chronic Disease;Chronically Ill;Classification;Clinical;Clinical Trials;Communities;Connecticut;Controlled Clinical Trials;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 patient;cytokine release syndrome;Data;Defense Mechanisms;Delirium;Diabetes Mellitus;Disabling;Double-Blind Method;Elderly;Epidemic;Fatty acid glycerol esters;FDA approved;Fibrosis;fisetin;Flavonoids;follow-up;Food;Frail Elderly;frailty;Functional disorder;Geriatric Nursing;Geroscience;healthspan;Hospitalization;Hour;Human;human coronavirus;human old age (65+);Impaired cognition;Impairment;improved;Individual;Infection;Inflammation;Inflammatory Response;Influenza;Inhalation;Intensive Care;Intervention Trial;Investigational Drugs;men;Michigan;Minnesota;Monkeys;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multiple chronic conditions;Multiple Organ Failure;Murine hepatitis virus;Mus;Myocardial Infarction;Natural Products;Network-based;Normal Cell;Nurses;Nursing Homes;Odors;old mice;older adult;older patient;Older Population;Outcome;Oxygen;Palliative Care;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physical Function;Pilot Projects;Placebo Control;Placebos;Population;prevent;Prevention;primary outcome;Proteins;Pulmonary Fibrosis;Recovery;Research;Resistance;Respiratory Failure;Risk;Running;Safety;Sampling;secondary outcome;Secondary Prevention;senescence associated secretory phenotype;senescent cell;senolytics;side effect;Skin;Strawberries;Stretching;Stroke;Structure of parenchyma of lung;Study Subject;supplemental oxygen;Symptoms;Taste Perception;Temperature;Testing;Texas;Thinness;Thrombosis;Tissues;United States National Institutes of Health;Universities;Urine;Viral;Virus;Vulnerable Populations;Woman

PROJECT_TITLE: COVID-FIS: A PHASE 2 PLACEBO-CONTROLLED PILOT STUDY IN COVID-19 OF FISETIN TO ALLEVIATE DYSFUNCTION AND EXCESSIVE INFLAMMATORY RESPONSE IN OLDER ADULTS IN NURSING HOMES


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD);Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Narrative Pain from Chronic Overlapping Pain Conditions is a pain management challenge for the physician and patient. This discovery-driven proposal will use multiple behavior and imaging techniques in an innovative longitudinal design to identify changes in brain activity and lipid neurochemistry in an animal model of chronic overlapping pain conditions. Combined with molecular and pharmacological approaches we will identify and validate novel targets for therapeutic intervention.

PI_NAMEs: MELEMEDJIAN, OHANNES KEVORK;TRAUB, RICHARD J (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acute;Acute Pain;Address;Affect;Affective;American;Amygdaloid structure;Animal Model;Animals;Area;awake;Behavior;Brain;Brain imaging;Brain region;brain tissue;Central Nervous System;Characteristics;Chronic;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinical;comorbidity;cost;Country;Data;Disease;druggable target;Enzymes;epidemiologic data;Female;Fibromyalgia;Functional Imaging;Functional Magnetic Resonance Imaging;Genetic;genetic manipulation;Hippocampus;Hypersensitivity;Imaging Techniques;Individual;Inflammation;Injury;innovation;Insula of Reil;interdisciplinary approach;Irritable Bowel Syndrome;knock-down;lipid structure;Lipids;longitudinal design;Magnetic Resonance Imaging;male;mass spectrometric imaging;Mass Spectrum Analysis;Masseter Muscle;Measures;Medial;Mediating;Medical;Metabolic;Metabolic Pathway;Metabolism;Methods;Microinjections;Modeling;Molecular;multidisciplinary;multimodality;Neurobiology;neurochemistry;new therapeutic target;novel;Opioid;opioid epidemic;orofacial;Orofacial Pain;Pain;Pain management;Pain Measurement;pain model;pain sensitivity;Pathway Analysis;Patients;perceived stress;Peripheral;pharmacologic;Pharmacological Treatment;Physicians;Pre-Clinical Model;Prefrontal Cortex;Rattus;Reporting;response;Role;Sensory;Sex Differences;Small Interfering RNA;Specificity;Stress;Structure;Symptoms;Temporomandibular Joint Disorders;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissue imaging;tissue stress;Tissues;tool;Translating;Validation;Visceral;Visceral pain;Woman

PROJECT_TITLE: Novel target identification for treatment of chronic overlapping pain using multimodal brain imaging


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Nanotechnology;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to discover a novel pain mechanism that underlies the most common types of chronic pain and validate a therapeutic target within that mechanism. This work will lay the foundation for the development of new types of medication that alleviates chronic pain including chronic inflammatory, neuropathic and cancer pain. Thus, the proposal directly addresses part of the mission of the NIH - to reduce illness and disability.

PI_NAMEs: BUNNETT, NIGEL W (contact);SCHMIDT, BRIAN L

PROJECT_TERMS: addiction liability;Address;Afferent Neurons;Agonist;antagonist;antinociception;biophysical techniques;Calcitonin;Calcitonin Gene-Related Peptide;cancer pain;Cell membrane;chronic pain;chronic pain management;Clathrin;Clinical;Clinical Trials;clinically significant;comparative efficacy;conventional therapy;design;Development;disability;Disease;drug development;drug discovery;Drug Targeting;Early Endosome;Electrophysiology (science);Encapsulated;Endocytosis;Endosomes;Environment;extracellular;Failure;Family;Foundations;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Transcription;Goals;GTP-Binding Proteins;Human;imaging approach;inflammatory pain;injured;innovation;Ion Channel;Ligands;Mediating;Membrane;Mission;Modeling;mouse model;Mus;nanoparticle;neuronal excitability;Neurons;Nociception;Nociceptors;novel;Nucleosome Core Particle;Opioid Receptor;Pain;pain model;pain receptor;pain relief;painful neuropathy;PAR-2 Receptor;Patients;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;Process;Property;Public Health;receptor;Research;Role;Sensory;side effect;Signal Transduction;Signaling Protein;spontaneous pain;Stimulus;Substance P;TACR1 gene;Testing;Therapeutic;therapeutic target;Tissues;Translations;transmission process;Treatment Efficacy;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Targeting Endosomal Receptors for Treatment of Chronic Pain


PHR: The focus of this application is on the impact of providing depressed veterans and their providers with the results of pharmacogenetic (PGx) testing for psychotropic medications. The project focuses on whether and how patients and providers use genetic test results given to them at the time an antidepressant is to be initiated to treat Major Depressive Disorder (MDD) and whether use of the test results improves patient outcomes. MDD is one of the most common conditions associated with military service and combat exposure, increases suicide risk, and worsens the course of common medical conditions, making it a leading cause of functional impairment and mortality. Validation of a PGx test to personalize the treatment of MDD represents an important opportunity to improve the healthcare of Veterans.

PI_NAMEs: OSLIN, DAVID W. (contact)

PROJECT_TERMS: adherence rate;Affect;Age;Alcohol consumption;alcohol use disorder;anti-depressive agents;Antipsychotic Agents;Antisocial Personality Disorder;Area;Bipolar Disorder;Businesses;Cannabis;Cardiovascular Diseases;care costs;Caring;Characteristics;Clinical;clinical application;clinical care;combat;commercialization;Complex;Consent;cost;Data Sources;Depressed mood;depressive symptoms;Development;Diagnosis;Disease;Disease remission;dosage;Drug Use Disorder;DSM-V;Early Diagnosis;Early treatment;Eating Disorders;Economics;Education;Effectiveness;Ensure;Epidemiology;Ethics;Exclusion Criteria;experience;Functional impairment;functional improvement;future implementation;Genetic Markers;genetic testing;Genetic Variation;Genomics;group intervention;Health;Healthcare;Healthcare Systems;Hospitalization;implementation study;improved;inclusion criteria;indexing;Informed Consent;Inpatients;Insurance Carriers;Intervention;knowledge translation;Major Depressive Disorder;Measures;Medical;Medicine;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Metabolism;Methods;military service;Modeling;mortality;Nicotine;novel marker;Obesity;Outpatients;Patient Care;Patient-Focused Outcomes;Patients;personalized cancer therapy;personalized medicine;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Post-Traumatic Stress Disorders;precision medicine;pressure;Process;programs;Provider;Psychiatry;Psychotherapy;psychotic;Questionnaires;Randomized;randomized, clinical trials;Recommendation;Research;routine care;Schizophrenia;secondary outcome;Severities;shared decision making;side effect;Site;suicidal risk;Test Result;Testing;Time;Tobacco use;treatment adherence;treatment as usual;treatment response;United States;United States Centers for Medicare and Medicaid Services;Validation;Variant;Veterans;Veterans Health Administration;Visit;Work

PROJECT_TITLE: PRIME Care (PRecision medicine In MEntal health Care)

STUDY_SECTION_NAME: Health Services Research[HSR0]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Narrative Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best evidence-based care available. AboutFace is a novel peer education program that features the personal stories of Veterans and is designed to improve Veterans’ likelihood of engaging in PTSD specialty care. Using a randomized controlled study design we propose to compare the efficacy of AboutFace relative to standard care for improving treatment engagement and outcomes. Additional data from VA providers will provide valuable information on wide scale implementation and dissemination of AboutFace. If AboutFace increases access of services, data will have broad implications for overcoming barriers to care for Veterans with PTSD and other stigmatized conditions.

PI_NAMEs: GRUBAUGH, ANOUK L (contact);HAMBLEN, JESSICA L

PROJECT_TERMS: Attitude;Award;Awareness;barrier to care;behavioral health;Caring;Clinic;Clinical;comorbidity;comparative efficacy;Data;design;Development;digital;Disease;Dissemination and Implementation;Education;education resources;Educational Materials;Enrollment;Ensure;evidence base;Evidence based treatment;experience;feasibility trial;follow-up;Funding;Future;future implementation;Goals;Grant;Health Services Accessibility;Healthcare;help-seeking behavior;implementation strategy;Improve Access;improved;indexing;Intake;Intervention;Interview;Learning;Location;medical specialties;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;novel;optimism;Outcome;peer;Persons;Pilot Projects;Post-Traumatic Stress Disorders;practice setting;Process;programs;Provider;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recommendation;Research;Research Design;Resources;Risk;Role;service delivery;Services;social stigma;standard care;Stigmatization;Strategic Planning;stress related disorder;Symptoms;treatment as usual;Trust;United States Department of Veterans Affairs;Update;usability;Veterans;Veterans Health Administration;Visit

PROJECT_TITLE: Randomized Controlled Trial of AboutFace: A Novel Video Storytelling Resource to Improve Access, Engagement, and Utilization of Mental Health Treatment among Veterans with PTSD


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Our newest war Veterans have complex care needs that the VA is striving to understand and address. While post-deployment mental health (MH) conditions and readjustment concerns are prevalent in this group, most Veterans do not access needed care. Our research team developed a web-based interface (WEB-ED) that screens for common post-deployment MH conditions and provides tailored education and linkage to VA resources that significantly increases engagement with needed care. This study seeks to develop and test WEB-ED enhancements (WEB-ED+) that integrate a shared decision-making (SDM) process and eHealth interface to assist secure messaging of MH/SDM interfaces with VA providers. Findings will help us to understand WEB-ED+ usability and adaptability for routine use by Veterans and VA practitioners, and to improve VA MH care access and patient-centered care for Veterans.

PI_NAMEs: SADLER, ANNE  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Advocate;alternative treatment;arm;care delivery;Caring;Chronic;Clinical;Clip;Collaborations;combat veteran;comorbidity;Complex;Computerized Medical Record;cost effective intervention;Data;Development;Disparity;Education;Educational Materials;eHealth;Enrollment;evidence base;Family;Feedback;Female;Geography;Health;health care availability;Health Promotion;Healthcare;Homelessness;Improve Access;improved;informant;innovation;Interruption;Intervention;Investments;Legal;Link;male;Managed Care;Measures;Medical;men;Mental Health;Mental Health Services;Methods;Military Personnel;Outcome;patient engagement;patient oriented;Patient-Centered Care;Patients;Perception;Phase;policy implication;primary health service;Process;process evaluation;Provider;provider adoption;Randomized;Randomized, Controlled Trials;Research;Resources;Rural;rural area;Rural Health;satisfaction;screening;Screening Result;Secure;Services;sexual trauma;shared decision making;social stigma;stakeholder perspectives;System;Testing;Triage;usability;Veterans;Vocation;War;web based interface;web services;Woman;Women's Health;Work

PROJECT_TITLE: Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Opioid medications are used to treat pain, but can they can cause serious problems. This project will fill a gap in the area of pain management for Veterans with painful disorders by examining whether complementary and integrative health approaches, such as acupuncture, yoga, meditation, and massage, help reduce the need for opioids. We will identify Veterans in VA with painful musculoskeletal disorders, including back and neck conditions. We will then determine which Veterans have used complementary and integrative health, and then examine whether it helped reduce the use of opioid medications, without causing Veterans to have additional problems, such as depression. We will examine which Veterans benefited most, with particular attention paid to those with PTSD, and then estimate how many other Veterans may benefit. This study will help to improve pain care practices in the VA and identify factors that are related to better quality pain care. Successful completion of this project has important public health implications both within and outside VA.

PROJECT_TERMS: Acupuncture Therapy;addiction;Adopted;Adverse event;adverse outcome;Algorithms;Area;Attention;Back;Benzodiazepines;Caring;Cause of Death;Characteristics;chronic pain management;Clinic;Clinical;cohort;Cohort Studies;comorbidity;Complementary Health;Congresses;Current Procedural Terminology Codes;Data;Depressive disorder;Diagnosis;Disease;Documentation;Education;Effectiveness;Electronic Health Record;Event;evidence base;experience;Future;Guidelines;Health;health data;Health Services;High Prevalence;high risk;improved;Incidence;informatics tool;Integrative Medicine;interest;International Classification of Disease Codes;Intervention;Laws;Massage;Meditation;Mental Depression;mindfulness;Modality;Modeling;Morbidity - disease rate;mortality;Musculoskeletal Diseases;musculoskeletal disorder diagnosis;Neck;Newly Diagnosed;non-cancer chronic pain;Nonpharmacologic Therapy;Opioid;opioid misuse;opioid policy;opioid use;Outcome;Overdose;Pain;Pain management;pain outcome;Pain quality;pain relief;pain symptom;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Pharmacy facility;Population;Post-Traumatic Stress Disorders;prescription opioid;programs;Provider;Psychological reinforcement;Public Health;Recovery;Reporting;Research;response;Risk;Role;Series;Services;side effect;Standardization;Statistical Data Interpretation;structured data;Subgroup;Surveys;Symptoms;theories;Time;Title IX;unstructured data;Veterans;willingness;Woman;Yoga

PROJECT_TITLE: ASSOCIATION OF COMPLEMENTARY AND INTEGRATIVE HEALTH (CIH)INTERVENTIONS WITH OPIOID USE AND RELATED RISKS AMONG VETERANS WITH MUSCULOSKELETAL DISORDERS (MSD) AND PTSD

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


PHR: Veterans involved in the criminal justice system have complex mental health and medical treatment needs and an elevated risk for mortality. They may also experience disparities in quality of care – barriers could include patient factors (e.g., trust in the healthcare system) and provider/system factors (e.g., competing demands in the clinical encounter). The proposed project aims to understand the nature, magnitude, and drivers of disparities in quality of care among justice-involved Veterans. The perspectives of Veteran and staff stakeholders will help identify and contextualize disparities in quality of care. The ultimate goal of this research is to improve the quality of care received by a particularly vulnerable Veteran population, in an effort to improve their health and mortality risk.

PI_NAMEs: FINLAY, ANDREA K (contact)

PROJECT_TERMS: addiction;Address;administrative database;Automobile Driving;Behavioral Model;care seeking;care systems;Caring;Characteristics;clinical encounter;Code;Colorectal Cancer;comorbidity;Complex;Consolidated Framework for Implementation Research;contextual factors;Continuity of Patient Care;Criminal Justice;Data;Data Collection;Dedications;demographics;Disparity;Emotional;experience;Foundations;Fright;Future;General Population;Goals;Health;Health Services Accessibility;Health system;Healthcare Systems;Hearing;Hepatitis C;HIV;HIV/HCV;Homelessness;Hospitalization;Hypertension;improved;Individual;informant;Interview;Justice;Measures;Medical;medical specialties;Mental disorders;Mental Health;Mental Health Services;Methods;military veteran;Morbidity - disease rate;mortality;mortality risk;Nature;Needs Assessment;operation;outreach;outreach program;Patients;Pattern;Perception;Pharmaceutical Preparations;Policies;Population;Process;programs;Provider;provider factors;Psychosocial Influences;Quality of Care;Research;Research Personnel;residence;Resources;Risk;Risk Factors;secondary analysis;Site;social;social stigma;Structure;Substance Use Disorder;Supervision;System;Trust;unconscious bias;Variant;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Quality of Care for Justice-Involved Veterans: Gaps, Predictors, and Stakeholder-Driven Solutions


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Project Narrative This study aims to improve the health and satisfaction of Veterans with chronic musculoskeletal pain by better understanding the effectiveness of five types of evidence-based complementary and integrative health, which are non-pharmacologic options to treat their pain and comorbid mental health conditions.

PI_NAMEs: TAYLOR, STEPHANIE L (contact);ZELIADT, STEVEN BACCHUS

PROJECT_TERMS: Acupuncture Therapy;addiction;Address;arm;Back;Caring;chiropracty;chronic musculoskeletal pain;Clinical;clinical care;Code;Collaborations;collaboratory;Combined Modality Therapy;comorbidity;comparative effectiveness;comparative effectiveness trial;Complementary Health;Congresses;Data;Data Collection;design;Development;dissemination strategy;Education;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness measure;Electronic Health Record;evidence base;examination questions;Fatigue;Health;Healthcare;Healthcare Systems;improved;Individual;instrument;Integrative Medicine;Learning;Measurement;Meditation;Mental Health;Methods;mindfulness;Modeling;Musculoskeletal Pain;Neck;Nonpharmacologic Therapy;novel;opioid use;Outcome;Pain;Pain management;Pamphlets;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Phase;physical conditioning;Policies;pragmatic trial;prevent;Primary Care;Process;programs;Provider;Randomized;Recovery;Reporting;Research;Research Personnel;Resources;response;Review Literature;Role;Sampling;satisfaction;Self Care;Site;Standardization;Statutes and Laws;Surveys;Tai Ji;tool;treatment effect;United States National Institutes of Health;Veterans;Yoga

PROJECT_TITLE: Complementary and Integrative Health for Pain in the VA: A National Demonstration Project


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE This study will delineate the role of endogenous retroviral expression (ERV) in high grade glioma which are driven by the H3K27M mutation. We will explore mechanisms of ERV activation, expression, and detection towards defining points of cellular vulnerabilities as new therapeutic strategies.

PI_NAMEs: MACK, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Acetylation;anti-cancer;Anti-viral Response;Apoptosis;Binding;Biology;Brain;Brain Neoplasms;cancer cell;Cell Maintenance;Cell model;Cell Proliferation;Cells;Complex;Cytoprotection;demethylation;Deposition;Detection;Development;DNA;DNA Methylation;Double-Stranded RNA;Electroporation;Elements;embryo cell;embryonic stem cell;Enzymes;Epigenetic Process;Evolution;experimental study;Family member;Functional disorder;gene repression;genetic approach;Genetic Transcription;Glioma;H3 K27M mutation;helicase;Histone Acetylation;Histone H3;histone methylation;histone modification;Human;Human Genome;Impairment;in utero;inhibitor;insight;Interferon Type I;Knock-out;Lysine;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Methionine;Methylation;Mitochondria;Modeling;Mutate;Mutation;neoplastic cell;nerve stem cell;neural growth;novel;novel therapeutic intervention;Nucleosomes;oncohistone;overexpression;Pathway interactions;Patients;Pattern;Play;Polycomb;Proliferating;Reader;Recurrence;Regulation;Regulatory Pathway;Repetitive Sequence;Repression;response;Role;self-renewal;Signal Pathway;Signal Transduction;Signaling Protein;stem cell differentiation;Testing;Therapeutic;transcription factor;Transcriptional Activation;Translational Repression;tumor;Tumor Promotion;tumorigenesis;Viral;Virus Diseases

PROJECT_TITLE: Deciphering the Role of Aberrant Endogenous Retroviral Expression in Onco-histone Driven Glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Narrative African American adults have two-times the risk of developing Alzheimer's Disease compared to other ethnic groups. The current study (called “RAATE”) will determine if regular physical activity conducted over a year will reduce risk factors for developing Alzheimer's Disease in older African American adults. We will assess participants brain functioning, brain structure, memory, and chromosomes.

PI_NAMEs: CARMICHAEL, OWEN T.;NEWTON, ROBERT LEE (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;African American;African American population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Anti-Inflammatory Agents;Auditory;Base Sequence;Basic Science;Biological Factors;Blood;Blood Vessels;Brain;brain tissue;Brain-Derived Neurotrophic Factor;cardiorespiratory fitness;cardiovascular risk factor;Cardiovascular system;caucasian American;Caucasians;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chromosomes;Chronic;circulating biomarkers;Clinical;clinical phenotype;Cognitive;cognitive enhancement;cognitive function;Communities;Control Groups;Dancing;Data;Diet;Education;Effectiveness;efficacy evaluation;Elderly;Episodic memory;Ethnic Population;Exclusion;executive function;Exercise;exercise intervention;exercise training;Exposure to;fitness;Functional Magnetic Resonance Imaging;genetic risk factor;Goals;group intervention;health disparity;healthy aging;Hippocampus;Hormones;Human;Impaired cognition;improved;inflammatory marker;Insulin-Like Growth Factor I;Intervention;intervention effect;intervention refinement;Ischemia;Knowledge;Learning;Length;life span;Link;Literature;Magnetic Resonance Imaging;Measures;Memory;mild cognitive impairment;moderate-to-vigorous physical activity;Nerve Degeneration;Neurobiology;neuroprotection;neurotrophic factor;older adult;Other Genetics;Outcome Measure;Participant;Pathway interactions;Perfusion;Physical activity;Physiological;Population;Prevalence;prevent;primary outcome;programs;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Design;Risk;Risk Factors;Risk Reduction;Structure;Target Populations;telomere;Testing;Time;Treatment Efficacy;trial design;United States National Institutes of Health;VO2max;White Matter Hyperintensity;Work

PROJECT_TITLE: Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)