NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Regenerative Medicine

PI_NAMEs: CHANDEL, NAVDEEP S (contact)

PROJECT_TERMS: Acquired disability;Acute;Acute Respiratory Distress Syndrome;Alveolar;Alveolar Macrophages;Attenuated;Blood capillaries;Cause of Death;Cessation of life;Clinical;Complex;conditional knockout;cytokine;Data;Dendritic Cells;disease model;Effector Cell;Electron Transport;Electron Transport Complex III;Enzymes;Epithelium;Exudate;Failure;Floods;Functional disorder;functional restoration;Funding Opportunities;Generations;Genetic;Glucose;Glycolysis;Goals;Hospitals;IL18 gene;Immune response;Immune signaling;Impaired wound healing;Impairment;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza infection;inhibitor;Instruction;Interferon Type I;Knockout Mice;Laboratories;lactate dehydrogenase A;Lung;Lung infections;lung repair;Macrophage;Membrane;Messenger RNA;Metabolic;Metabolic Control;Metabolic Pathway;Mitochondria;monocyte;Morbidity - disease rate;mortality;Mus;Natural regeneration;Organ;Pathology;Patients;pharmacologic;Plasma;prevent;Process;Production;Proton Pump;Pyruvate;pyruvate carrier;Reactive Oxygen Species;receptor;Recovery;recruit;Regulation;repaired;Research;Research Personnel;response;Signal Transduction;Site;Sodium Lactate;Specificity;Syndrome;Testing;Time;Tissues;tool;Viral;Viral Load result;Viral Pneumonia;Virus;Virus Diseases;Work

PROJECT_TITLE: Project 2: Metabolic regulation of host response and repair mechanisms to influenza A viral pneumonia


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Estrogen;Genetics;Human Genome;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Narrative Biological sex and gender impact immune function. In order to understand how sex and gender impact sexually dimorphic immunologic disease states, we intend to identify sex and gender specific regulatory signatures on developmental differences of the immune system.

PI_NAMEs: PISARSKA, MARGARETA  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adult;anakinra;Ankylosing spondylitis;Asthma;Autoimmune Diseases;Biological Process;Biological Response Modifiers;biological sex;Cell Physiology;cell type;Cells;Childhood;Chromatin;cytokine;Cytokine Gene;Development;differential expression;Disease;Disease Progression;early childhood;Environment;Estradiol;Exposure to;Family;Female;fetal;Fetus;First Pregnancy Trimester;Flow Cytometry;Gender;gender difference;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;High Prevalence;Hormonal;hormone regulation;Hormones;Immune;immune function;Immune system;Immune System Diseases;Immunity;Immunologics;in utero;Individual;life span;Ligands;male;Maternal-Fetal Exchange;member;men;MMP9 gene;Multiple Sclerosis;Peripheral Blood Mononuclear Cell;personalized approach;Placenta;Placentation;Play;Pregnancy;Prevalence;Puberty;receptor;response;Rheumatoid Arthritis;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Stanolone;Surface;Systemic Lupus Erythematosus;Testosterone;Transcriptional Regulation;transcriptome;Transforming Growth Factor beta

PROJECT_TITLE: The impact of sex and gender on disease progression, from developmental origins


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative We propose to study the microfluidics devices that can exploit the biophysical responses of cells to ultrafast compressions. We will further study applications in which we deliver probes and reprogramming reagents to cells using the microfluidics. We aim to create new technologies for the delivery of large transgenes and probes to many cell types.

PI_NAMEs: SULCHEK, TODD  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Active Biological Transport;Affect;Biological;Biological Markers;Biomechanics;Biophysics;cancer cell;Cancer cell line;Carcinoma;cell behavior;Cell membrane;Cell Separation;Cell Survival;cell type;Cell Volumes;Cells;cellular engineering;Charge;Contrast Media;CRISPR/Cas technology;Cytoplasm;Cytoskeleton;design;Device Designs;Devices;Diagnostic;DNA delivery;Electroporation;extracellular;Extracellular Fluid;Gene Delivery;Genetic;genome editing;Goals;Grant;Health;Hematopoietic stem cells;in vivo imaging;induced pluripotent stem cell;innovation;iron oxide nanoparticle;Knowledge;Lab On A Chip;Label;lipofection;Liquid substance;Location;macromolecule;mechanical force;Mechanics;Mediating;Membrane;Mesenchymal Stem Cells;Messenger RNA;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;millisecond;Modeling;Modification;Molecular;nanoparticle;Needles;new technology;novel;novel strategies;Nuclear Structure;particle;Phenotype;plasmid DNA;pressure;Process;programs;Property;Proteins;Reaction;Reagent;Relaxation;response;Route;sensor;Series;stem cells;T-Lymphocyte;Testing;Therapeutic;Time;Transfection;Transgenes;Trauma;uptake;Viral

PROJECT_TITLE: Microfluidics to explore ultrafast cell deformations to deliver large cargo via convective transport

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE It is not required per instructions stated on the Funding Opportunity Announcement PAR-18-405, Section IV. Application and Submission Information, Project, Research & Related Other Project Information (Project), “Project Narrative: Do not complete.”

PI_NAMEs: BUDINGER, GR SCOTT  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Acute Respiratory Distress Syndrome;Alveolar;alveolar epithelium;Alveolar Macrophages;Attenuated;Biological;Cell Physiology;Cells;Cessation of life;Clinical;community acquired pneumonia;Complex;cytokine;Data;Development;Epithelial Cells;epithelial repair;Epithelium;experimental study;Failure;Functional disorder;Funding Opportunities;Genes;Genetic Transcription;Heme;Hypoxemia;improved outcome;individualized medicine;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;Infrastructure;Injury;insight;Instruction;Interferon Type I;Iron Regulatory Protein 2;Ligase;Liquid substance;Lung;lung injury;lung repair;Macrophage;Measures;Mediating;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;NF-kappa B;Organ;Outcome;Paper;participant enrollment;pathogen;Patients;Phenotype;Physiological;Play;Pneumonia;pneumonia treatment;prevent;Proteins;Recovery;Regulation;repair function;repaired;Reporting;Research;Resolution;Respiratory Failure;response;Role;Signal Transduction;Supportive care;Techniques;Therapy trial;transcription factor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Pneumonia;Virus Diseases

PROJECT_TITLE: Project 3: Targeting linear ubiquitination to attenuate inflammation and promote repair after viral pneumonia

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Because Latino children are disproportionately affected by short sleep duration, poorly timed sleep, and obesity by the age of 3 years, it is critical to understand factors that may contribute to both sleep and obesity in this population. This study will advance our understanding of how environmental (e.g., household, neighborhood, societal), sociocultural (e.g., acculturation, beliefs), and parental (e.g., sleep-related parenting practices) factors contribute to toddler sleep and toddler weight status over a 2-year period in Mexican American families, one of the largest growing ethnic minority populations in the U.S. By identifying contextual factors and modifiable behaviors that must be considered for intervention design, this study will contribute to the development of family-focused, culturally-tailored, and contextually-informed early prevention programs focused on sleep and weight status in this underserved population.

PI_NAMEs: MELTZER, LISA J;THOMPSON, DARCY ANN (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 3 year old;Acculturation;actigraphy;Adolescent;Affect;Area;Belief;Child;Child Rearing;Childhood;contextual factors;critical developmental period;Data;design;Development;Devices;Diet;Disparate;Disparity;early childhood;early-onset obesity;Ecology;Enrollment;Ensure;Environmental Risk Factor;ethnic minority population;Evaluation;Family;Fathers;Focus Groups;Future;Growth;Health;Health behavior;high risk;Home;Household;Household and Family;Hypertension;improved;innovation;Intervention;Knowledge;Latino;Life;Long-Term Effects;Longitudinal Studies;Low income;Measurement;Measures;Mediator;metropolitan;Mexican Americans;Modeling;modifiable behavior;Mothers;multidisciplinary;Napping;neighborhood disadvantage;Neighborhoods;Noise;Nursery Schools;Obesity;obesity in children;obesity prevention;Outcome;Parents;Physical activity;Population;Prevalence;Prevention program;primary caregiver;Qualitative Methods;Questionnaires;Reduce health disparities;Reporting;Research;resilience;response;Schedule;Sleep;sleep behavior;Sleep Deprivation;social culture;sociocultural determinant;System;Systems Theory;Target Populations;therapy design;Time;Toddler;Underserved Population;Weight;Work

PROJECT_TITLE: Sleep and Obesity in Toddlers from Mexican American Families


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This P01 project has public health significance, because brain and cognitive dysfunction are among the most important health issues encountered by persons living with HIV as they age. Our P01 will evaluate three promising interventions that may improve cognitive functioning among persons with HIV who consume alcohol.

PI_NAMEs: COHEN, RONALD A;COOK, ROBERT L (contact);GOVIND, VARAN

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Advisory Committees;Affect;Age;Alcohol consumption;alcohol research;Alcohols;Autonomic nervous system;behavior change;Biological;Biosensor;Brain;brain dysfunction;brain health;brain pathway;Cephalic;Charge;Clinical;Clinical Data;Clinical Research;clinical trial participant;Clinical Trials;Cognition;Cognitive;cognitive function;Collection;community advisory board;community engagement;comorbidity;contingency management;cooking;Data;Data Analytics;data management;Data Science;Data Science Core;data sharing;Development;drinking;dysbiosis;effective intervention;Enrollment;Ethnic Origin;experience;Failure;Feedback;Florida;Future;future implementation;Gender;Goals;Grant;gut bacteria;gut microbiome;gut-brain axis;hazardous drinking;Health;high risk drinking;HIV;HIV Infections;HIV-associated cognitive impairment;Hybrids;Impaired cognition;improved;improved outcome;incentive strategies;Individual;individual response;Inflammation;Infrastructure;Intervention;Leadership;Learning;Link;Machine Learning;microbial;Monitor;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;Nerve;Nervous System;neuroimaging;neuroinflammation;Neurologic;Outcome;Outcome Assessment;Participant;payment;Persons;Phase;Population;Population Heterogeneity;prevent;probiotic supplementation;Productivity;programs;Public Health;Quality of life;Race;Randomized;Readiness;recruit;Research;Research Activity;Research Infrastructure;scale up;Structure;success;systemic inflammatory response;Training and Infrastructure;Training Programs;Training Support;transmission process;trial design;U-Series Cooperative Agreements;Vagus nerve structure;Variant;wearable device;Work;Wrist

PROJECT_TITLE: Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;HIV/AIDS;Infectious Diseases;Microbiome;Neurosciences;Substance Misuse

PI_NAMEs: COOK, ROBERT L (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Affect;Age;Aging;alcohol research;Alcohols;Autonomic nervous system;biobank;Brain;Clinical;Clinical Research;Cognition;Cognitive;Collaborations;Communication;Communities;community advisory board;community engagement;community setting;comorbidity;cooking;County;Data;Data Collection;Data Science Core;Development;Discipline;Doctor of Philosophy;Enrollment;Ensure;Epidemiology;Ethnic Origin;experience;Faculty;Florida;Future;Geographic Distribution;Goals;Growth;gut microbiome;gut-brain axis;Health Personnel;HIV;HIV Infections;Human Resources;improved;Infrastructure;Institution;International;Intervention;Leadership;Link;Measures;Medicine;member;Memory;Monitor;National Institute on Alcohol Abuse and Alcoholism;operation;organizational structure;Outcome;Paper;Pathway interactions;Patient Recruitments;Persons;Pilot Projects;Population Heterogeneity;Process;professor;programs;Protocols documentation;Quality Control;Race;recruit;reduced alcohol use;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;rural area;Safety;Sampling;Services;sexual minority status;Strategic Planning;Structure;Students;Training;Training Activity;Training Programs;transmission process;Universities;University resources

PROJECT_TITLE: Administrative Core: Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

PHR: PROJECT NARRATIVE – ESI-LED PROJECT 4 A Project Narrative is not required per instructions stated in the Funding Opportunity Announcement PAR-18- 405, Section IV. Application and Submission Information, ESI-Led Project, Research & Related Other Project Information (ESI Project), “Project Narrative: Do not complete.”

PI_NAMEs: SINGER, BENJAMIN DAVID (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adoptive Transfer;Age;age related;aged;Aging;aging process;Alveolar;Amphiregulin;Anti-viral Therapy;AREG gene;Case/Control Studies;cell age;Cell Physiology;Cells;computational platform;computerized tools;COVID-19;COVID-19 pandemic;COVID-19 pneumonia;Data;Development;DNA;DNA Methylation;DNA methyltransferase inhibition;DNA Modification Methylases;Elderly;Epigenetic Process;Epithelium;Exhibits;experience;experimental study;FOXP3 gene;Functional disorder;Funding Opportunities;Gene Expression Profile;Generations;Genetic Transcription;Genomic Instability;Global Change;Growth Factor;hallmarks of aging;healthspan;Human;Hypermethylation;Impairment;Inflammation;Influenza;Influenza A virus;influenza epidemic;Injury;Instruction;Intervention;Laboratories;life span;Link;Lung;lung injury;lung repair;Mediating;methylation pattern;mortality;mouse model;multiple chronic conditions;Mus;normal aging;novel;old mice;older patient;Paper;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physiological;predictive signature;premature;Premature aging syndrome;Printing;programs;Publishing;Recovery;Recovery of Function;Regulatory T-Lymphocyte;repair function;repaired;Research;Resolution;Respiratory Tract Infections;Risk;Role;Survivors;System;Testing;Therapeutic;Time;Viral;Viral Pneumonia;Virus;Wild Type Mouse;Youth

PROJECT_TITLE: Project 4: Epigenetic modifiers of regulatory T cell function following viral pneumonia


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention;Substance Misuse

PI_NAMEs: LI, ZHIGANG  (contact)

PROJECT_TERMS: alcohol abstinence;Alcohol consumption;alcohol effect;alcohol measurement;Alcoholic beverage heavy drinker;Alcohols;Artificial Intelligence;artificial intelligence model;Bacterial Translocation;Big Data;Biological Markers;Characteristics;clinical practice;Clinical Trials;Clinical Trials Design;cohort;Collaborations;comorbidity;Complement;Data;Data Analyses;Data Collection;data harmonization;data management;Data Management Resources;Data Pooling;data resource;Data Science Core;Data Security;data sharing;Databases;deep learning;design;Development;Disease;electronic data capture system;Ensure;Equity;Ethics;Etiology;experience;Faculty;Goals;gut microbiome;gut-brain axis;Health Policy;Heavy Drinking;HIV;HIV Infections;Human Resources;improved;Individual;Intervention;intervention effect;Intervention Studies;Intestinal permeability;Learning;Lobe;Machine Learning;machine learning model;Measurement;Mediation;Methodology;Methods;microbial;microbiome;Modeling;multimodal neuroimaging;Neurocognitive;neuroimaging;novel;Online Systems;Outcome;Pathogenicity;Pathway interactions;Patients;personalized intervention;Persons;population health;power analysis;predictive modeling;predictive tools;Prevention strategy;Procedures;Protocols documentation;Public Health;Public Policy;Publications;Qualifying;Quality Control;Randomized;randomized, clinical trials;Recommendation;reduced alcohol use;Research;research data dissemination;Research Design;Research Personnel;Research Project Grants;Resources;risk mitigation;Sample Size;Scheme;Series;Services;Site;Source;Statistical Data Interpretation;statistical learning;success;System;systemic inflammatory response;Techniques;Testing;Tissues;tool;Training;Training Programs;Translational Research;trial design;Validation;Wit;Work

PROJECT_TITLE: Data Science Core: Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PHR: Project Narrative The primary goals of the ECOG-ACRIN NCORP Research Base are: 1) to advance our understanding of approaches to prevent cancer and cancer-related physical and psychological symptoms, and 2) to develop and evaluate strategies to translate advances in high quality cancer care delivery into community oncology settings, with the aim of reducing the burden of cancer.

PI_NAMEs: ODWYER, PETER J;SCHNALL, MITCHELL D.;WAGNER, LYNNE I. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Abbreviations;Adolescent and Young Adult;Adopted;advanced disease;Advocacy;Advocate;American College of Radiology Imaging Network;anti-cancer research;Area;Attention;base;Behavioral;biobank;Biological Markers;biomarker driven;Biostatistical Methods;Breast Magnetic Resonance Imaging;Cancer Biology;Cancer Burden;cancer care;cancer clinical trial;Cancer Control;cancer prevention;Cancer Prevention Trial;Cancer Research Network;Cancer Survivorship;cancer therapy;Cardiotoxicity;care delivery;career development;Caring;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;community collaboration;community engagement;Complex;Continuity of Patient Care;control trial;Data Science;Dedications;Development;Diagnosis;Discipline;Disparity;Early Diagnosis;Eastern Cooperative Oncology Group;eHealth;Elderly;Ensure;ethnic minority;experience;financial toxicity;Fostering;Funding;gender minority;Goals;Health equity research;health related quality of life;high risk;high risk population;Image;imaging biomarker;imaging modality;Immunooncology;improved;individualized prevention;Influentials;Infrastructure;innovation;Institution;interest;International;Intervention;Laboratories;Leadership;Malignant Neoplasms;Measurement;Medical;member;Minority;minority engagement;Mission;Monitor;multidisciplinary;National Cancer Institute;National Clinical Trials Network;novel;novel marker;Nurses;oncology program;operation;overtreatment;Participant;Patient Outcomes Assessments;Patients;personalized approach;physical symptom;Physicians;Population;Population Heterogeneity;Populations at Risk;Postdoctoral Fellow;precision oncology;prevent;Prevention;Prevention strategy;Prevention trial;Primary Prevention;Process;programs;Provider;psychological symptom;Quality of life;racial minority;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Resources;risk mitigation;Risk Reduction;rural dwellers;Science;Scientist;screening;Screening for cancer;Secondary Prevention;Sexual and Gender Minorities;Site;support network;survivorship;symptom science;Symptoms;System;team-based care;Therapeutic Trials;tissue biomarkers;Tissue imaging;Tissues;Translating;Translational Research;Underrepresented Minority;Underserved Population;Work

PROJECT_TITLE: ECOG-ACRIN NCORP Research Base


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with systemic sclerosis, and a disease for which no therapies conclusively alter mortality or target the central pathogenic cells. The differentiation of resident pulmonary fibroblasts to aberrant myofibroblasts is a key process in the pathogenesis of SSc-ILD. This work will define the gene regulatory programs fundamental to SSc-ILD myofibroblast differentiation and the pathogenic myofibroblast phenotype and determine the mechanisms by which RUNX2/3 regulate critical myofibroblast effector functions.

PI_NAMEs: VALENZI, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Affect;analytical tool;ATAC-seq;Autoimmune;Autoimmune Diseases;Automobile Driving;Binding;Binding Sites;Biological Assay;career development;Cause of Death;Cell Nucleus;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Complex;Computational Biology;Critical Care;Data;Deposition;design;Development;Disease;DNA;DNA Binding;effective therapy;Effector Cell;Environment;Epigenetic Process;Etiology;Extracellular Matrix;Fibroblasts;Fibrosis;fibrotic lung disease;Fostering;gain of function;Gases;gene regulatory network;Genes;Genetic Transcription;genome-wide;Genomics;Goals;Human;Hypersensitivity;improved;Interstitial Lung Diseases;Investigation;K-Series Research Career Programs;Knowledge;leadership development;Link;Lung;Medicine;Mentors;Molecular Biology;mortality;multiple omics;Myofibroblast;novel therapeutics;Pathogenesis;Pathogenicity;Patients;Phenotype;Physicians;Population;Process;Production;professor;programs;Publishing;Pulmonary Fibrosis;Regulation;Regulatory Element;Research;Research Proposals;Rheumatism;Role;RUNX3 gene;Sampling;Scientist;Sclerosis;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;skin fibrosis;Source;Structure of parenchyma of lung;Systemic Scleroderma;therapeutic target;transcription factor;Transcription Factor 3;transcriptome;transcriptome sequencing;Transposase;United States;Universities;Work

PROJECT_TITLE: Uncovering the genomic regulatory network of myofibroblast differentiation in systemic sclerosis-associated interstitial lung disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: LEEMAN, ROBERT F (contact)

PROJECT_TERMS: Abstinence;Acceleration;Address;Age;Agreement;alcohol abstinence;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol research;alcohol testing;Alcohols;Behavior;behavior change;Biological;Biosensor;Cellular Phone;Characteristics;Clinic;Cognition;Cognitive;cognitive enhancement;cognitive function;comorbidity;Consumption;contingency management;cost;drinking;drinking behavior;efficacious intervention;Enrollment;executive function;Eye;Failure;Feedback;Financial cost;follow-up;Friends;General Population;gut-brain axis;Health;Health behavior;Healthcare Systems;Heavy Drinking;HIV;HIV Infections;IL6 gene;implementation science;improved;Inflammation;innovation;Intervention;Liquid substance;Methods;mHealth;Minority;Monitor;motivational enhancement therapy;Neighborhood Health Center;novel;novel strategies;Outcome;outcome prediction;Participant;patient engagement;Persons;Physical Function;Population;Psychological reinforcement;Public Health;Publishing;Randomized;reduced alcohol use;Research;Risk;Risk Factors;Sampling;sensor technology;Severities;social;substance misuse;systemic inflammatory response;Technology;Testing;TNF gene;transmission process;usability;user-friendly;Viral Load result;Wrist

PROJECT_TITLE: Novel Extensions of Alcohol Contingency Management in People Living with HIV


NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The development of lung inflammation and fibrosis is a significant complication that limits the effectiveness of stem cell transplantation as a cure for cancer or autoimmune disease. This proposal seeks to understand how the process of stem cell transplant alters the natural bacterial communities in the lung, and how those altered microbial communities influence the development of immune responses that lead to inflammation and fibrosis. Successful completion of the work should identify bacterial-based therapeutic options to improve outcomes for patients.

PI_NAMEs: ZHOU, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute Lung Injury;adaptive immunity;Address;Allogenic;Animal Model;Antibiotics;Area;Autoimmune Diseases;Bacteria;bacterial community;Butyrates;C Type Lectin Receptors;Cell Physiology;Chronic Lung Injury;Cidofovir;Clinical;Complication;curative treatments;Data;Dendritic Cells;Development;Dexamethasone;Disease;dysbiosis;Effectiveness;Etiology;Family;Fibrosis;Functional disorder;Germ-Free;Goals;Hematopoietic Stem Cell Transplantation;Herpesviridae;Herpesviridae Infections;Human;Idiopathic pneumonia syndrome;IL17 gene;Immune response;Impairment;improved outcome;Infection;Infectious Agent;Inflammation;Injury;Lactobacillus;Ligands;Link;Lung;lung development;Lung Diseases;lung injury;lung microbiome;lung microbiota;Lung Transplantation;Lytic Phase;Malignant Neoplasms;Mediating;Metagenomics;microbial community;microbiome;microbiome therapeutics;microbiota;microbiota composition;microbiota transplantation;Mission;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Mus;neoplastic;notch protein;novel;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Play;pneumonitis and fibrosis;Pre-Clinical Model;Primary Infection;Process;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonary Pathology;reactivation from latency;Regulation;Research;response;Risk;Role;Stem cell transplant;Techniques;Testing;Therapeutic;Toll-like receptors;Transplant Recipients;Transplanted Lung Complication;United States National Institutes of Health;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Microbiota Regulation of Pulmonary Complications Post-HCT

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Patient Safety;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: COLUMBUS COMMUNITY CLINICAL ONCOLOGY PRG

ORG_STATE: OH

PHR: The Columbus Community Clinical Oncology Program has been serving Central Ohio for 35 years and has been participating in the NCI Community Oncology Research Program since its inception. During that time, the Columbus CCOP has excelled in delivering cancer care and access to clinical studies to a wide variety of populations – from major urban areas to rural Appalachia. The Columbus CCOP is firmly committed to the idea that cancer therapy and clinical trials are mutually supportive, and looks forward to continuing to work and grow as an NCORP community site.

PI_NAMEs: WILSON, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Advanced Malignant Neoplasm;Aftercare;Amish;anti-cancer research;Appalachian Region;Area;cancer care;Cancer Control;cancer prevention;Cancer Science;cancer therapy;care delivery;Caring;Clinical;clinical practice;Clinical Research;Clinical Trials;Collaborations;Colon Carcinoma;Communication;Communities;Community Clinical Oncology Program;Community Hospitals;community organizations;Comprehensive Cancer Center;Country;data management;data quality;Data Storage and Retrieval;Dedications;design;Disparity;Education;follow-up;gene therapy;Genomics;Goals;Grant;health disparity;improved;Incidence;Individual;innovation;Institution;Institutional Review Boards;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Managed Care;member;Minority Groups;Minority Participation;Nurses;Ohio;participant enrollment;Patients;Persons;Physicians;Population;Positioning Attribute;Prevention;Primary Care Physician;programs;Research;Research Personnel;research study;Rural;Rural Appalachia;Rural Community;screening;Services;side effect;Site;Specialist;success;symposium;targeted treatment;Time;Translating;treatment research;underserved community;urban area;Work

PROJECT_TITLE: Columbus NCORP RFA-CA-18-016


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors are drugs that have revolutionized the treatment of lung and bladder cancer as well as other cancer types. Despite their success at improving patient survival, they do not work in all patients and often have serious side effects. The goal of this project is to identify biomarkers that predict immune checkpoint inhibitor efficacy and/or side effects.

PI_NAMEs: BUCKNER, JANE HOYT (contact);LINSLEY, PETER S

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adverse event;Allergic Disease;Antigen Targeting;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;Biological Markers;biomarker identification;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cells;Characteristics;checkpoint inhibition;checkpoint therapy;Clinical;Clone Cells;cohort;Collaborations;Cytometry;Data Analyses;Development;Disease;Frequencies;Goals;Heterogeneity;high dimensionality;Human;Hypersensitivity;Immune;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunophenotyping;improved;Individual;individual response;inhibitor therapy;innovation;insight;Joints;Knowledge;Longitudinal cohort;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;National Cancer Institute;novel strategies;Oncologist;Oncology;Patient Care;Patients;peripheral blood;pharmacodynamic biomarker;Phenotype;Play;Positioning Attribute;predict clinical outcome;predicting response;predictive marker;programmed cell death protein 1;Property;Regulatory T-Lymphocyte;response;Role;Sampling;Self Tolerance;side effect;single-cell RNA sequencing;Solid Neoplasm;Source;success;T cell regulation;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;Tumor Antigens;Work

PROJECT_TITLE: Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapy


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;HIV/AIDS;Infectious Diseases;Microbiome;Neurosciences;Nutrition;Prevention;Substance Misuse

PI_NAMEs: PORGES, ERIC  (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Alcohol consumption;alcohol effect;alcohol research;alcohol risk;Alcohols;Anti-Inflammatory Agents;antiretroviral therapy;Bacteria;Biological;biological adaptation to stress;Biological Markers;Blood;Brain;brain dysfunction;brain health;Cardiovascular system;cholinergic;clinically significant;co-infection;Cognition;Cognitive;cognitive function;cognitive testing;Collaborations;comorbidity;cytokine;Data;Data Science Core;design;dysbiosis;effective intervention;Enrollment;Evaluation;fecal microbiome;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;gastrointestinal;Glutathione;Goals;gut dysbiosis;gut microbiome;gut-brain axis;Health;Heavy Drinking;Hepatitis;high risk;high risk sexual behavior;HIV;HIV Infections;Homeostasis;Human;Hybrids;immune function;immune reconstitution;Impaired cognition;improved;indexing;Inflammation;Inflammatory;Intervention;Intestinal permeability;Link;Liquid substance;Liver diseases;Machine Learning;Measures;microbial;microbiome composition;microbiota-gut-brain axis;mortality;Motility;Nerve;neural network;Neurocognition;Neurocognitive;neuroimaging;neuroinflammation;Obesity;Outcome;Parasympathetic Nervous System;Participant;Pathogenicity;Pathologic;Pathway interactions;Peripheral;Persons;Phase;Placebos;poor health outcome;Postdoctoral Fellow;pre-doctoral;Prevalence;probiotic supplementation;Probiotics;Process;Property;Public Health;Quality of life;Randomized;randomized, clinical trials;Research;Research Infrastructure;Research Personnel;Rest;Risk Behaviors;scale up;Serum;System;systemic inflammatory response;Testing;Therapeutic;Therapeutic Effect;Training Programs;transmission process;treatment adherence;United States National Institutes of Health;vagus nerve stimulation;Vagus nerve structure;Viral Load result;viral transmission

PROJECT_TITLE: Cognitive and Inflammation Targeted Gut-Brain Interventions in People Living with HIV who are High-Risk Alcohol Users


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetic Testing;Genetics;Heart Disease;Human Genome;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The current proposal seeks to uncover the population genetic determinants of dilated cardiomyopathy (DCM), the leading global cause of heart transplantation. With growing availability of genetic data, an improved understanding of DCM genetics may permit genomic risk prognostication as part of routine clinical practice, enabling early identification and management of patients at risk for DCM, and thereby mitigating risk – and the potential need for heart transplantation – before the onset of disease. Furthermore, identification of putative drug targets through genetic discovery may motivate the development of novel therapeutics capable of altering the poor prognosis that is currently associated with DCM.

PI_NAMEs: ARAGAM, KRISHNA G (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Active Learning;Advisory Committees;Alcohol consumption;Atrial Fibrillation;biobank;Board Certification;Body mass index;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiovascular system;career;Circulation;Classification;Clinical;Clinical assessments;Clinical Data;Clinical Informatics;Clinical Medicine;clinical practice;clinical risk;Cloud Computing;cohort;Complex;Complex Genetic Trait;Computational Biology;connectin;Coupled;Data;Databases;Development;Dilated Cardiomyopathy;Disease;disease-causing mutation;Drug Targeting;Early identification;Electronic Health Record;Environment;Environmental Risk Factor;Epidemiology;exome sequencing;General Hospitals;General Population;Genes;Genetic;genetic analysis;Genetic Determinism;genetic epidemiology;Genetic Predisposition to Disease;Genetic Risk;genetic testing;genetic variant;genome wide association study;Genomic medicine;Genomics;Genotype;Healthcare;Heart failure;heart imaging;Heart Transplantation;Heritability;improved;Individual;inherited cardiomyopathy;instructor;Internal Medicine;International;Investigation;Joints;lifestyle factors;Link;loss of function mutation;Massachusetts;Mediating;Medical Genetics;medical schools;Medicine;Mentors;Mentorship;Meta-Analysis;multidisciplinary;Mutation;mutation carrier;Myocardial Infarction;next generation sequencing;non-genetic;novel;novel therapeutics;Onset of illness;Outcome;Participant;Pathogenesis;Patients;Penetrance;Perinatal;Phenotype;phenotypic data;Physicians;polygenic risk score;Population;population based;Population Genetics;Positioning Attribute;Predictive Value;Predisposition;Productivity;Prognosis;prognostication;programs;prospective;rare variant;Research;Research Personnel;responsible research conduct;Risk;Risk Factors;risk mitigation;Role;Scientist;skills;Structure;sudden cardiac death;Testing;Training;Training Activity;Variant;Veterans;Work

PROJECT_TITLE: Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Veterans who access health care from multiple systems are at risk of experiencing fragmented care. Fragmented care can lead to feelings of mistrust, abandonment, and isolation. Fragmentation created by dual use of VA and non-VA services creates inefficiency, unnecessary care, and worse outcomes. The 2018 MISSION Act and Medicaid expansion under the ACA result in more health care options for Veterans, but also increased risk of fragmented care. We will assess choices Veterans made about their care after Medicaid expansion. We will focus on a group particularly vulnerable to fragmented care–patients with complex health care needs from advanced chronic kidney disease. As VA incorporates more non-VA sources of care under the MISSION Act, understanding trade-offs between increasing access and ensuring high quality, coordinated care will become a central question for VA. Understanding how Veterans choose to access care when given multiple options is key to making health system improvements in resource deployment and care coordination.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;Accountability;Adopted;Affect;Affordable Care Act;American;beneficiary;Cardiovascular Diseases;care coordination;care costs;care fragmentation;care outcomes;care systems;Caring;Characteristics;Chronic;Chronic Kidney Failure;comorbidity;Complex;Comprehensive Health Care;cost;Data;demographics;Diabetes Mellitus;Dialysis procedure;Dual Enrollment;Eligibility Determination;Emergency department visit;Emotional;enhanced care;Enrollment;Ensure;experience;Face;falls;Feeling;Financial Contribution;Health;health care availability;Health Care Costs;health care delivery;health care quality;health care service;health care service utilization;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;Household;Improve Access;improved;improved outcome;Income;innovation;Insurance Carriers;Interview;Investigation;Kidney;Kidney Diseases;Low income;Mediating;Medicaid;Medicaid eligibility;medical specialties;Medicare;member;Methodology;Mission;Modeling;mortality;Natural experiment;Outcome;Outpatients;Patient Care;Patients;Pattern;payment;Persons;policy recommendation;Primary Care Physician;Process;programs;Provider;Quality of Care;Research;Resources;Risk;Services;Severity of illness;Source;Strategic Planning;Structure;Subgroup;System;Time;tool;tool development;Transplantation;Uninsured;Uninsured Medical Expense;United States Dept. of Health and Human Services;Veterans;Visit;Work

PROJECT_TITLE: Medicaid Expansion and Quality, Utilization and Coordination of Health Care for Veterans with Chronic Kidney Disease

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Diseases of the heart and lungs may result in critical illness in children and these diseases are major contributors to infant deaths in the United States. This program will train young investigators who will be capable of discovery of important underlying mechanism of disease and will contribute to improved outcomes of illness in critically ill children.

PI_NAMEs: BEMBEA, MELANIA MARIA;EVERETT, ALLEN D (contact);NORTHINGTON, FRANCES J

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TITLE: Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE There is an urgent need to identify new targets to improve present cancer immunotherapies and to make them effective in a larger subset of patients. In this grant application we identify TREM2, a receptor present on immune cells that infiltrate the tumor, as a promising target for cancer therapy in combination with other immune checkpoint blockade strategies.

PI_NAMEs: COLONNA, MARCO  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: 3-Methylcholanthrene;Address;Adipose tissue;Alzheimer's Disease;Alzheimer's disease model;anti-PD-1;antitumor effect;Appearance;Applications Grants;Arterial Fatty Streak;Attention;Awards and Prizes;Binding;Blocking Antibodies;Breast Cancer Model;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer therapy;carcinogenesis;Catabolism;Cause of Death;Cell Line;Cell surface;Cessation of life;checkpoint therapy;chemotherapy;Cholesterol;Cholesterol Esters;Chronic;chronic inflammatory disease;Cleaved cell;Colorectal;Complement;Complex;CTLA4 gene;Data;Defect;Diagnosis;Disease;disease model;effector T cell;Fibrosis;Foam Cells;Generations;Genes;Genetic study;Goals;High Fat Diet;Host Defense;Human;human cancer mouse model;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immune system;Immunologic Receptors;Immunosuppression;immunosuppressive macrophages;Immunotherapy;improved;Infiltration;inhibiting antibody;ITAM;Knowledge;Lipid Binding;lipid metabolism;Lipids;Lipoprotein Binding;Lipoproteins;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;MC38;Mediating;Membrane;Metabolism;Metalloproteases;Methylcholanthrene;Microglia;Modeling;Monoclonal Antibodies;Mouse Mammary Tumor Virus;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Newly Diagnosed;Nobel Prize;novel therapeutic intervention;Oncology;Pathway interactions;patient subsets;Patients;Peripheral;Phospholipids;polyoma middle tumor antigen;Population;Pre-Clinical Model;prevent;Process;programmed cell death protein 1;programs;receptor;Reporting;Resolution;response;Risk Factors;Senile Plaques;Shapes;Signal Transduction;standard care;subcutaneous;Subcutaneous Injections;success;targeted cancer therapy;Testing;Therapeutic;Tissues;Transgenic Mice;transmission process;TREM2 gene;tumor;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;United States;Variant;Virus Diseases

PROJECT_TITLE: Targeting TREM2 to boost anti-cancer therapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine;Sleep Research

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Our long-term goal to harness the power of circadian rhythms to ameliorate lung injury. The current proposal investigates the mechanistic underpinnings of cell autonomous clocks relevant to circadian protection from Influenza infection in both the acute phase and subsequent recovery.

PI_NAMEs: SENGUPTA, SHAON  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Adult;Affect;Alveolar;Anti-viral Agents;ARNTL gene;biobank;Bioinformatics;Biological Assay;Cell Cycle Regulation;Cell Death;Cells;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Data;Ensure;Epithelium;Evaluation;experimental study;Exposure to;Genes;Genetic;Goals;Health;Histologic;Hospitalization;Immune;immunopathology;Impairment;in vivo;Infection;Inflammatory;Influenza;Influenza A virus;influenza infection;inhibitor;Injury;Jet Lag Syndrome;Knock-out;Ligands;Lung;lung injury;lung regeneration;lung repair;Modeling;mortality;Mus;Myelogenous;Natural regeneration;novel;novel therapeutic intervention;Organoids;Other Genetics;Outcome;Pathway interactions;Pattern;Phase;Phenotype;Physiologic pulse;Publishing;Recovery;regenerative biology;Regenerative capacity;repaired;Reporter;Risk Factors;Role;Sampling;Sentinel;Signal Transduction;Testing;Therapeutic;Time;Tissues;tool;transcriptomic profiling;Vaccines;Viral;Viral Load result;virology;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Mechanistic evaluation of the role of circadian rhythms in acute lung injury and subsequent recovery

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Following current treatment regimens, clinical outcome in patients with high-risk Myelodysplastic syndrome (MDS) and Acute Myeloid Leukemia (AML) with mutant RUNX1 remains poor. Research proposed here will conduct a clinical trial of a novel combination of omacetaxine mepisuccinate (OM) and venetoclax along with correlative science studies, as well as develop additional novel and rational OM-based combinations for therapy of MDS or AML with mutant RUNX1.

PI_NAMEs: BHALLA, KAPIL ;DINARDO, COURTNEY  (contact);TAKAHASHI, KOICHI

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Age;AML/MDS;analog;Architecture;ATAC-seq;attenuation;autosome;Biogenesis;c-myc Genes;chemotherapy;ChIP-seq;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;co-clinical trial;Combined Modality Therapy;Complex;Core-Binding Factor;Coupled;Data;Data Set;Disease remission;DNA Binding;Dysmyelopoietic Syndromes;Enrollment;Epigenetic Process;Familial Platelet Disorder;Gene Expression;Gene Expression Profile;Genetic;Germ Lines;Germ-Line Mutation;graft vs host disease;Guide RNA;Harvest;Hematopoiesis;high risk;homoharringtonine;Homologous Transplantation;Impairment;improved;In Vitro;in vivo;in vivo Model;inhibitor;knock-down;Lesion;Libraries;loss of function mutation;Malignant - descriptor;Maps;MCL1 gene;Mediating;Messenger RNA;Molecular;Mus;mutant;Mutation;Myeloproliferative disease;Network-based;new therapeutic target;Newly Diagnosed;next generation sequencing;novel;Outcome;participant enrollment;Patients;Phase Ib/II Clinical Trial;Phase Ib/II Trial;preclinical efficacy;Prognosis;Progression-Free Survivals;Protein Inhibition;Proteins;Recurrent disease;Refractory;Relapse;Repression;Research;Resistance;response;Ribosomes;Risk;RUNX1 gene;Safety;Science;small hairpin RNA;targeted agent;targeted treatment;Tertiary Protein Structure;transcription factor;transcriptome sequencing;Translations;Treatment Protocols;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel combination therapy for AML expressing mutant RUNX1

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative Shigella species are a major global cause of morbidity and mortality, estimated to be responsible for 269 million cases and 212,000 deaths annually. There is no approved vaccine and only a poor understanding of natural or vaccine-elicited immunity, in large part because of the lack of a physiological mouse model of infection. In this application, we propose to take advantage of our development of a new oral infection mouse model of shigellosis to answer fundamental questions about Shigella pathogenesis and immune responses to this important global pathogen.

PI_NAMEs: VANCE, RUSSELL E (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Actins;adaptive immune response;Animal Model;Animal Testing Alternatives;Back;Bacteria;Bacterial Proteins;Body Weight decreased;CASP4 gene;Caspase;Cavia;Cells;Cessation of life;cost;cytokine;Data;Development;Disease;Dissection;Dose;Eicosanoids;Epithelial Cells;Epithelium;Exhibits;Feces;Fever;Flagellin;Foundations;gut colonization;gut inflammation;Hemorrhagic colitis;Human;Human Characteristics;human disease;human pathogen;Immune;Immune response;Immunity;Immunocompromised Host;Immunologics;in vivo;Infant;Infection;Inflammasome;Inflammatory Response;interest;intestinal epithelium;Intestines;intraperitoneal;Invaded;Knowledge;Lung;Mediating;Methodology;Modeling;Morbidity - disease rate;mortality;Motility;mouse genetics;mouse model;Mus;Muscle Cramp;mutant;Natural Immunity;Needles;neutrophil;Neutrophil Infiltration;Oral;oral infection;Oral Ingestion;Organoids;Oryctolagus cuniculus;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Physiological;Predisposition;Primates;Protein Secretion;Reagent;Research;Research Personnel;Resistance;response;Rod;Route;Salmonella;Salmonella infections;sensor;Shigella;Shigella Infections;success;Tail;Testing;Time;tool;Type III Secretion System Pathway;Vaccines;Virulence Factors;Work;Zebrafish;Zinc deficiency

PROJECT_TITLE: Dissection of Shigella pathogenesis in vivo using a new oral infection mouse model

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative This training grant application focused on lung biology and pathobiology requests continuing support for 7 predoctoral and 6 postdoctoral trainees. The Training Program is grounded in 5 inter-related thematic areas of research training: (1) Biology and Pathobiology of Lung Vasculature, (2) Regenerative Mechanisms in Lung and Vascular Biology, (3) Cellular and Humoral Bases of Lung Inflammation and Injury, (4) Cell Signaling Mechanisms in Lung Injury, and (5) Lung and Vascular Genomics. We are well positioned to continue to train a highly-qualitied group of young scientists, providing a range of skills needed in a rapidly-evolving and increasingly competitive scientific environment that can be applied in careers in both academic research and alternative pathways.

PI_NAMEs: MEHTA, DOLLY  (contact)

PROJECT_TERMS: Biology;Lung;Training Programs

PROJECT_TITLE: Training Program in Lung Biology and Pathobiology


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_CITY: TAIPEI

ORG_COUNTRY: TAIWAN

ORG_FIPS: TW

ORG_NAME: NATIONAL TAIWAN UNIVERSITY

PHR: PROJECT NARRATIVE This proposal will leverage the Asian Bipolar Genetics Network (A-BIG-NET), an international collaboration of investigators from the U.S., Taiwan, South Korea, Singapore, India and Pakistan, to carry out a molecular genetics study of bipolar disorder in East and South Asia. It will establish a valuable genetics resource with 4x low-pass whole genome sequence and rich phenotype data that will dramatically increase the worldwide diversity of genetics data on bipolar disorder, an important step to accelerate gene discovery in this disorder and advance global mental health equity.

PI_NAMEs: KUO, PO HSIU  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adopted;Adult;Alleles;Asia;Asian;Asian Americans;Asian ancestry;Asian population;Bipolar Disorder;causal variant;Clinical;cohort;Collaborations;comparative;Complement;Consensus;Country;Data;data archive;data collection site;Disease;disorder subtype;DNA;East Asian;Environmental Risk Factor;environmental stressor;Equity;European;European ancestry;experience;field study;Funding;gene discovery;Gene Frequency;Genetic;genetic architecture;genetic association;Genetic Diseases;Genetic Research;genetic resource;genetic risk factor;genetic signature;Genetic study;genetic variant;Genetic Variation;genome sequencing;genomic data;genomic locus;Genomics;Genotype;health disparity;health equity;India;insight;International;Joints;Maps;Measures;Mental disorders;Mental Health;Modeling;Molecular;Molecular Genetics;National Institute of Mental Health;Nature;neuropsychiatric disorder;novel;Outcome;Pakistan;Pathogenesis;Phenotype;phenotypic data;Play;pleiotropism;polygenic risk score;Population;Prevalence;Procedures;Process;Production;Protocols documentation;psychiatric genomics;psychogenetics;Public Health;Publications;Quality Control;rare variant;Records;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Sampling Studies;Schizophrenia;severe psychiatric disorder;Singapore;Site;South Asian;South Korea;Taiwan;Time;Uncertainty;Variant;web portal;whole genome;Work

PROJECT_TITLE: 4/4 Asian Bipolar Genetics Network (A-BIG-NET)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(60)C]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Nanotechnology;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Relevance The proposed research aims to develop a novel general strategy to enhance radiotherapy for cancer treatment. These results will help advance cancer therapy with better treatment outcome and quality of life while the radio- and chemo-toxicity to healthy tissues is much minimized.

PI_NAMEs: RAO, JIANGHONG  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;affective disturbance;androgen deprivation therapy;Apoptosis;Apoptotic;Biochemical;Brachytherapy;cancer care;cancer cell;Cancer Etiology;Cancer Patient;cancer radiation therapy;cancer therapy;Cardiovascular Diseases;CASP3 gene;Cells;Cessation of life;chemotherapy;Clinical;clinical application;Combined Modality Therapy;Deposition;design;Development;diabetes risk;Disease;Disease-Free Survival;Distant Metastasis;Dose;Dose Limiting;Drug Kinetics;drug release profile;Early treatment;Elements;empowerment;Epithelial Cells;External Beam Radiation Therapy;Failure;Feedback;Fluorescence;Follow-Up Studies;Functional disorder;Goals;health related quality of life;Heterogeneity;high risk;Hydrolysis;Iatrogenesis;Image;image guided;image guided radiation therapy;imaging facilities;imaging probe;Imaging Techniques;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;Intensity-Modulated Radiotherapy;Investigation;irradiation;Low Dose Radiation;Lymph Node Dissections;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medical center;men;Mental Depression;mouse model;nanoassembly;nanoparticle;nanoparticle delivery;Nanotechnology;neoplastic cell;novel;optimal treatments;Organ;partial response;Patients;Pelvic lymph node group;Penetration;Permeability;personalized intervention;Pharmaceutical Preparations;Phase I Clinical Trials;Population;Positron-Emission Tomography;Prodrugs;Property;Prostate;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;Quality of life;Radiation;Radiation Dose Unit;radiation effect;radiation response;Radiation therapy;Radiation Toxicity;Radiation-Sensitizing Agents;Radical Prostatectomy;Radio;Radiosensitization;Reactive Oxygen Species;Recurrence;Recurrent tumor;Reporting;Research;Resistance development;Scheme;self assembly;Sexual Health;side effect;small molecule;Specificity;systemic toxicity;targeted treatment;Technology;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Toxic effect;treatment effect;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;tumor;tumor heterogeneity;tumor xenograft;United States

PROJECT_TITLE: Targeting apoptotic cells to enhance radiotherapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Since 2011, the Amazon has experienced the largest percent increase in malaria cases in the world, with the highest increase in burden occurring in Venezuela, Peru, Brazil, Colombia and Ecuador. Through support from NASA, our team developed a Malaria Early Warning System (MEWS) for Peru that accurately predicts malaria cases 8-12 weeks in advance using sophisticated statistical models and environmental drivers of malaria transmission (i.e., climate, land cover, hydrology). The objective of this proposal is to geographically expand our MEWS to all Amazonian regions and obtain additional data to improve downscaling and forecasting by mapping community networks and potential migration routes related to malaria transmission.

PI_NAMEs: PAN, WILLIAM KUANG-YAO (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Academia;Address;Affect;Area;Bayesian Modeling;Behavioral;Border Community;Border Crossings;Brazil;Case Study;Censuses;Climate;Collaborations;Colombia;Communicable Diseases;Communities;Community Networks;Community Relations;comparison intervention;Country;Data;Data Collection;data infrastructure;Decentralization;Detection;Development;Disease;Disease Outbreaks;Economics;Ecuador;Ecuadorian;Ecuadorian Amazon;Effectiveness of Interventions;El Nino southern oscillation;Event;experience;extreme weather;Funding;Geography;Goals;Government;Health;Health system;Healthcare;hydrology;improved;Incidence;indexing;indigenous community;informant;Infrastructure;innovation;Internal Migrations;International;International Migrations;Intervention;Interview;Knowledge;land cover;Malaria;malaria transmission;Maps;migration;Modeling;Morbidity - disease rate;Native-Born;outbreak prediction;Pan American Health Organization;Pathway Analysis;Pattern;Performance;Peru;Politics;Population;preventive intervention;Probability;Prophylactic treatment;Reaction Time;Reporting;Research;Resources;response;Risk;risk sharing;Role;Route;Rural;Rural Population;Seasons;social;Social Distance;Social Network;socioeconomics;Source;South America;spatiotemporal;Specificity;Statistical Models;Structure;success;surveillance data;Surveys;System;Technical Expertise;Testing;Time;transmission process;Transportation;United States National Aeronautics and Space Administration;Vector Ecology;vector management strategies;Venezuela;Vulnerable Populations;Withdrawal

PROJECT_TITLE: Improving Response to Malaria Outbreaks in Amazon-Basin Countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE  This innovative new proposal is designed to supplement the education of postdoctoral trainees with MD, PhD, or equivalent degrees in the areas of pulmonary, allergy, or critical care medicine by supporting research in heart, lung, blood, and sleep related disorders. We built a research training curriculum to meet the special needs of these trainees and expose them to high standards of multidisciplinary medical research. Once they complete our highly adaptive program, trainees will have the knowledge and skills to pursue outstanding cutting-edge independent research careers that will give them the ability to rapidly translate scientific discoveries into better ways to diagnose and treat disease.

PI_NAMEs: DWEIK, RAED A. (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Supporting Multidisciplinary Achievement in Respiratory Research Training (SMARRT)

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CORAL GABLES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Organs-on-Chips are becoming an ever more popular tool to tackle the downsides of static cell cultures and animal models; while the standard models can demonstrate basic biological phenomenon, these models are inefficient for modeling disease and studying therapeutics in-vitro. While Organs-on-Chips are a better model, there is still a need to address their reliability and use in large scale studies. Here we propose improvements and experiments for a novel, organ-on-chip platform to recapitulate normal glomerular filtration, as well as glomerular hyperfiltration due to changes in hydrostatic pressure, osmotic pressure, and membrane stiffness.

PI_NAMEs: ALVER, CHARLES GARCIA (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;Animal Model;Apical;arteriole;Basement membrane;Biological Phenomena;Biomedical Engineering;Biomimetics;Body System;Caring;Cell Culture Techniques;Cells;Chronic Kidney Failure;Cicatrix;Coculture Techniques;Collagen;combat;Complications of Diabetes Mellitus;Congestive Heart Failure;constriction;Consumption;cost;Culture Media;Cytoskeleton;Development;Devices;Diabetes Mellitus;Diabetic Nephropathy;Dialysis procedure;Disease;disease model;Doctor of Philosophy;Endothelial Cells;experimental study;extracellular;Filtration;Gelatin;Generations;glomerular basement membrane;glomerular filtration;Glomerular Filtration Rate;Health;Heart Diseases;Heart failure;hemodynamics;Hereditary nephritis;Human;Hydrogels;Hydrostatic Pressure;Hypertrophy;improved;In Vitro;in vitro Model;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;Left;Liquid substance;Medicare;Membrane;Membrane Proteins;Mentors;Metabolic;Microfluidic Microchips;mimetics;Modeling;Nephrons;new technology;novel;organ on a chip;Osmolar Concentration;Osmosis;Osmotic Pressure;Pathogenesis;Pathologic;Patients;Persons;Physiological;Plasma;podocyte;Porosity;pressure;Proteins;renal damage;Renal function;response;Running;scaffold;Scientist;Side;skills;stem;System;Therapeutic Studies;Therapeutic Uses;tool;Training;Transplantation;United States;Up-Regulation

PROJECT_TITLE: Glomerulus on a Chip: A Model to Study Glomerular Hyperfiltration


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Sleep Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: PROJECT NARRATIVE Shift work disorder (SWD) is a widespread disorder that affects millions of night shift workers. However, SWD is also highly undertreated in part because the underlying mechanisms are not well characterized. The proposed project will elucidate critical and novel mechanisms driving SWD to inform future precision medicine approaches.

PI_NAMEs: CHENG, PHILIP  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Accidents;Acute;Address;Affect;alertness;Automobile Driving;Biological Clocks;circadian;Circadian desynchrony;Circadian Rhythms;Clinical;clinical translation;Cognitive Therapy;comparison control;Data;Disease;Disease remission;Drowsiness;Education;first responder;Future;Goals;hospital services;hypnotic;Light;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Noise;novel;occupational stress;operation;persistent symptom;Pharmaceutical Preparations;precision medicine;Precision therapeutics;prospective;Public Health;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Residual state;Risk;Role;Safety;Sampling;Schedule;Severities;shift work;Shift-Work Sleep Disorder;Sleep;Sleep Deprivation;Sleep disturbances;Sleeplessness;Stimulant;Stimulus;stressor;symptom management;Symptoms;Testing;time use;trait;Work

PROJECT_TITLE: Sleep reactivity as a novel mechanism in Shift Work Disorder

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: RELEVANCE (See instructions):  Tick-borne Disease (TbD) in the US has tripled due to both vector range expansions and emergence of  novel tick-transmitted pathogens, leading to increased morbidity and mortality. A major limitation of the  current detection techniques is the extreme bias towards detecting single pathogens and lack of  consideration of coinfections. Our MEDICO platform will diagnose babesiosis, anaplasmosis, and acute,  early-stage Lyme disease that share the same tick vector, I. scapularis, and often coexist.

PI_NAMEs: SRIVASTAVA, SOUMYA K (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Acute;Anaplasma phagocytophilum;Anaplasmosis;Area;Babesia microti;Babesiosis;bioelectricity;Bite;Black-legged Tick;Borrelia;career;career awareness;Case Study;cell behavior;Cell Physiology;cell type;Cells;Cellular biology;Centers for Disease Control and Prevention (U.S.);Chronic;climate change;Clinical;co-infection;college;Communicable Diseases;Complex;Coupling;Data;Data Set;design;Detection;detection method;detection platform;Development;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic technologies;dielectric property;Disease;Disease Surveillance;disease transmission;Early Diagnosis;Electric Capacitance;electric field;electric impedance;Electrophysiology (science);Environmental Monitoring;Equilibrium;Exposure to;Female;First Generation College Students;Food;Frequencies;Funding;Generations;graduate school;graduate student;high school;Hospitalization;Hybrids;Idaho;improved;In Vitro;Incidence;Infection;Instruction;instrumentation;integrated circuit;Intervention;Label;Learning;Liquid substance;Lyme Disease;Machine Learning;machine learning algorithm;machine learning model;mathematical model;Measures;Mechanics;Mentors;Methods;microdevice;Microfabrication;Microfluidics;Modality;Modeling;Morbidity - disease rate;mortality;Movement;multimodality;novel;novel strategies;open source;Optics;outreach;particle;pathogen;Pathogenesis;Performance;point of care;Population;programs;Property;Psyche structure;Publishing;recruit;Research;Resolution;response;Safety;Sampling;sensor;Signal Transduction;software repository;Sorting;Speed;STEM field;Student recruitment;System;Technical Expertise;Techniques;Testing;tick transmission;Tick-Borne Diseases;Time;undergraduate research;undergraduate student;Underrepresented Students;vector;vector tick;Vision;voltage;Water;West Virginia;Whole Blood;Work;work-study

PROJECT_TITLE: SCH: Machine LEarning & MicrofluiDics for Multimodal Sensing of TiCk-bOrne Diseases(MEDICO)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

PHR: PUBLIC HEALTH RELEVANCE Although there is a substantial burden of cervical cancer among Nigerian women, there are significant gaps in implementing both primary and secondary HPV prevention strategies. The study will engage young girls and their mothers to increase uptake of essential HPV prevention services. The findings from this study will be relevant to other resource-constrained settings that are expanding HPV vaccination and screening programs.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Address;African;Age;AIDS prevention;anti-cancer research;Applications Grants;Area;Cancer Burden;Cancer Control;cancer prevention;cancer vaccination;Cancerous;Caregivers;Cervical Cancer Screening;Clinic;Collection;Communities;community based participatory research;community clinic;community engaged approach;Community Health Aides;Community Participation;cost effectiveness;Country;crowdsourcing;Daughter;design;Development;direct application;Dissemination and Implementation;dissemination science;Dose;Economic Models;effectiveness evaluation;Elements;experience;experimental study;Female;girls;Goals;Government;Group Structure;health communication;Health Services Accessibility;HIV;HPV screening;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papillomavirus;Human papillomavirus 6;Immunization Programs;implementation evaluation;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;improved;Individual;Interdisciplinary Study;Intervention;Knowledge;Laboratories;Learning;learning community;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical Research;Methods;Modeling;Morbidity - disease rate;mortality;mother-daughter relationship;Mothers;National Cancer Institute;Nigeria;Nigerian;older women;Participant;Population;preference;premalignant;Prevention;prevention service;Prevention strategy;Preventive measure;primary outcome;Primary Prevention;Problem Solving;Proctor framework;programs;public health relevance;Quality-Adjusted Life Years;Randomized, Controlled Trials;Recommendation;Records;recruit;Research;Research Infrastructure;Resource-limited setting;Risk;risk perception;Sampling;scale up;screening;screening program;secondary outcome;Secondary Prevention;self testing;Services;social cognitive theory;Specimen;State Government;Strategic Planning;Techniques;Time;treatment as usual;United States;United States National Institutes of Health;uptake;Vaccination;vaccine acceptance;Woman;Work;Youth

PROJECT_TITLE: Actions for Collaborative Community Engaged Strategies for HPV (ACCESS-HPV)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a leading cause of death and disease among Black American women and is associated with pregnancy complications and experiences of early and chronic stress. We will measure health and behavioral indicators of CVD risk in a sample of Black women who have participated in a 20-year longitudinal study to examine the effects of lifetime stress exposure and stress reactivity on profiles of CVD risk across the first two years postpartum. New data from this study will improve understanding of CVD risk specific to Black women, and will inform the targets and timing of interventions to reduce persistent racial disparities in maternal health.

PI_NAMEs: HIPWELL, ALISON E (contact);LEVINE, MICHELE D

PROGRAM_OFFICER_NAME: PLEVOCK HAASE, KAREN MARIE

PROJECT_TERMS: Acute;acute stress;Address;Adult;adverse birth outcomes;Affect;Age Years;behavior change;Behavioral;biobehavior;Biological;biopsychosocial;Birth;Black American;Black race;black women;Blood;Blood Glucose;Blood Pressure;Buffers;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;causal model;Cause of Death;Childhood;Chronic stress;Conceptions;Data;Development;Diet;dietary;Discipline of obstetrics;Discrimination;Disease;early experience;Early identification;Exposure to;Fetal Development;Future;girls;Health;Health Personnel;Healthcare;heart rate variability;Heterogeneity;Hydrocortisone;improved;Individual Differences;inflammatory marker;innovation;Intervention;Knowledge;Laboratories;life span;Life Stress;Link;Lipids;Longitudinal Studies;Low income;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;minority stress;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Obesity;Outcome;Pathway interactions;Perinatal;Persons;Phenotype;Physiological;Polyunsaturated Fatty Acids;post pregnancy;postpartum health;Postpartum Period;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnancy Trimesters;Pregnant Women;prenatal;Prenatal care;prenatal stress;Prevention;Prevention Guidelines;preventive intervention;Primary Prevention;Prospective Studies;protective effect;Race;racial disparity;racial health disparity;racism;recruit;Regulation;Reproductive Health;Research;response;Risk;Risk Assessment;Role;Salivary;Sampling;Second Pregnancy Trimester;Smoking;Stress;stress reactivity;stress reduction;Stress Tests;stressor;System;Testing;theories;Third Pregnancy Trimester;Time;Violence;White Women;Woman;Women's Health;women's morbidity;Women's mortality;Work

PROJECT_TITLE: Preconception and prenatal stress effects on cardiovascular disease risk in black women


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE / RELEVANCE Disorders of the respiratory tract continue to be a major cause of morbidity and mortality, affecting tens of millions of people. Effective treatments are lacking or suboptimal due to our lack of understanding of the disease pathogenesis and a pool of scientists too small to meet the research needs. This grant will prepare MD and PhD scientists with superior training in areas relevant to lung biology and lung disease and equip them to be leaders in their selected field of research.

PI_NAMEs: KAMINSKI, NAFTALI  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Biology;Lung;Training

PROJECT_TITLE: Training in Translational Lung Biology and Pathobiology


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: NARRATIVE The Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials2 (HIPACT2) will build upon the success of the first cycle of HIPACT as a continuing partner in the Environmental Influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN). In this second five-year cycle of funding, with an engaged pediatric clinical faculty, newly committed partners and generous institutional support, HIPACT2 will increase opportunities for faculty development, participate in collaborative multicenter clinical trial research, and engage rural and underserved communities to improve health outcomes in Hawaii and across the nation.

PI_NAMEs: BALARAMAN, VENKATARAMAN  (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Achievement;Adolescent;Alaska Native;American Indians;Area;Asian population;base;Black Populations;Burn injury;Child;Child Health;Childhood;Clinic;clinical research site;Clinical Trials;Clinical Trials Network;Communities;Development;Discipline of obstetrics;Environment;Environmental Science;Ethnic Population;Faculty;faculty research;Funding;Geography;Goals;Gynecology;Hawaii;Hawaiian;Hawaiian population;Health;health inequalities;health outcome disparity;Hispanic Populations;Home;Immersion;Immigrant;improved;Indigenous;Infant;innovation;Institution;interest;invention;Leadership;Maternal-fetal medicine;Medical center;medical schools;Mentors;multi-ethnic;Multi-Institutional Clinical Trial;Native Hawaiian or Other Pacific Islander;neurodevelopment;Nursing Faculty;Obesity;Outcome;Pacific Islander;pediatric department;Pediatric Research;Perinatal;Personal Satisfaction;Population;postnatal;prenatal;Productivity;programs;Research;Research Personnel;Role;Rural;rural area;Rural Community;Scholars Program;Site;socioeconomics;success;Taxes;Teacher Professional Development;Traction;Training and Education;Trust;underserved area;underserved community;Universities;Woman

PROJECT_TITLE: Hawaii IDeA Center for Pediatric and Adolescent Clinical Trials 2 (HIPACT 2)


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Heart and vascular disease are common in individuals affected by diabetes and metabolic disorders. Development of advances to combat cardiometabolic disease requires scientists who understand both cardiovascular as well as metabolic science. This training program provides critical and structured guidance from both cardiovascular and metabolism investigators in an environment that is highly conducive to the matriculation of postdoctoral trainees who will be at the forefront of future advances in cardiometabolic science.

PI_NAMEs: HSUEH, WILLA A (contact);SMITH, SAKIMA AHMAD

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Postdoctoral Training in Cardiometabolic Science


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Clinical trials provide the highest quality research evidence for the effectiveness of medical treatments, but most pediatric clinical trials fail to achieve enrollment and retention goals. The Nebraska Pediatric Clinical Trials Unit (NPCTU) addresses this gap in improving child health outcomes by extending research infrastructure and clinical trials participation opportunities to children, families, and health care providers in rural and underserved communities across Nebraska and neighboring IDeA states. The NPCTU will build upon its initial successes in enrolling children into clinical trials conducted in the IDeA States Pediatric Clinical Trials Network by expanding rural outreach, research infrastructure, and professional development programs through collaborations with multiple institutional partners across Nebraska and other IDeA states.

PI_NAMEs: MCCULLOH, RUSSELL JAMES (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Adverse event;adverse event risk;Affect;Age;Awareness;Capital;career;Child;Child Health;Childhood;Chronic Disease;Clinic;Clinical Research;clinical trial enrollment;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communication;Communities;community advisory board;community engagement;community partnership;Conduct Clinical Trials;Contracts;Data;Development;Disease;drug efficacy;drug metabolism;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness measure;Enrollment;Ensure;Etiology;Event;Face;Faculty;Family;feasibility trial;Feedback;First Independent Research Support and Transition Awards;Funding;Gender;Goals;Great Plains;Health Personnel;Healthcare;high standard;Hospitalized Child;Human;improved;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Interview;Knowledge;Leadership;Life;Maintenance;Measures;Medical;Medical center;medically underserved;Mentorship;Metabolism;Multi-Institutional Clinical Trial;Nebraska;Nursing Faculty;off-label drug;off-label use;Outcome;outreach;participant enrollment;Pediatric Hospitals;pediatric patients;Pediatric Research;pediatrician;Performance;Persons;Pharmaceutical Preparations;Physicians;Physiology;Play;Positioning Attribute;Prevention;Productivity;Program Development;Program Effectiveness;programs;Protocols documentation;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;research facility;Research Infrastructure;Research Institute;Research Personnel;Resources;Risk;Role;Rural;rural area;Rural Community;rural dwellers;rural families;rural underserved;Safety;side effect;Site;skills;Socioeconomic Status;success;Time;Training;underserved area;underserved community;United States National Institutes of Health;Universities

PROJECT_TITLE: The Nebraska Pediatric Clinic Trials Unit


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative (Overall) Increasing faculty diversity in the biological, biomedical, and health sciences will contribute to the diversity of the academy, and future generations of the STEM workforce. Cornell University aims to increase the number of minoritized faculty in the biological, biomedical, and health sciences through establishing an NIH FIRST Program at Cornell University. Cornell FIRST will support the hiring and retention of 10 new assistant professors from groups underrepresented in their fields, while transforming institutional climate into a culture of inclusive excellence.

PI_NAMEs: AUGUST, AVERY  (contact);KOTLIKOFF, MICHAEL I.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academy;Acceleration;Advocacy;Area;Bacteriology;Behavioral Sciences;Biological;Biology;Biomedical Engineering;career;career development;Climate;cohort;college;Complex;Data;Development;early-career faculty;Environment;Epidemiology;Equity;Evaluation;evidence base;Faculty;faculty support;Fostering;Funding;Future Generations;health communication;health equity;Health Sciences;Immunology;Individual;Infection;Institution;Institutional Policy;Institutionalization;Interdisciplinary Study;interest;Learning;marginalization;Mentors;Minority;Mission;Modeling;Monitor;novel;organizational climate;Positioning Attribute;Privatization;professor;programs;Public Health;recruit;Research;Science;STEM career;success;System;Systems Biology;Teacher Professional Development;Testing;Underrepresented Populations;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Cornell FIRST


NIH_SPENDING_CATS: Aging;Cancer;Complementary and Integrative Health;Mental Health

PHR: Project Narrative Not applicable per RFA-RM-20-022

PI_NAMEs: AUGUST, AVERY  (contact)

PROJECT_TERMS: Academy;Acceleration;Advocacy;Bacteriology;Behavioral Sciences;Biological;Biology;Biomedical Engineering;career development;cohort;college;Complex;Development;early-career faculty;Environment;Epidemiology;Equity;Evaluation;evidence base;Faculty;faculty support;Fostering;Funding;Future Generations;health communication;health equity;Health Sciences;Immunology;Individual;Infection;Institution;Institutional Policy;Institutionalization;Interdisciplinary Study;interest;Mentors;Minority;Mission;Modeling;organizational climate;Positioning Attribute;Privatization;Process;professor;programs;Public Health;recruit;Research;Science;STEM career;success;System;Systems Biology;Testing;Underrepresented Populations;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Cornell FIRST Administration Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


NIH_SPENDING_CATS: Aging;Cancer;Complementary and Integrative Health;Mental Health;Social Determinants of Health

PROJECT_TERMS: Academy;Address;Adopted;Advocate;anti-racism;Area;Biological;career development;career life balance;career networking;Climate;Cognitive;cohort;college;Communication;Communities;community building;Country;design;Development;Development Plans;Discipline;Early identification;early-career faculty;Education;Educational process of instructing;Ensure;Environment;evidence base;experience;experimental study;Faculty;faculty community;Financial Support;Fostering;Funding;Future Generations;Grant;Growth;Guidelines;Health Sciences;implicit bias;Individual;innovation;Institution;Investments;Laboratories;marginalization;Measurable;member;Mentors;Michigan;Minority;Modeling;Pathway interactions;peer;Policies;Process;Program Development;programs;Research;research and development;Risk;Role;Services;social;Social Network;Soil;STEM career;Structure;success;Teacher Professional Development;Testing;Training and Education;Travel;Universities;Woman;Writing

PROJECT_TITLE: Faculty Development


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Complementary and Integrative Health;Mental Health

PROJECT_TERMS: Academy;Acceleration;Address;Advocacy;Bacteriology;Behavioral Sciences;Biological;Biology;Biomedical Engineering;career development;Climate;cohort;Collaborations;college;Complex;design;Development;early-career faculty;Ensure;Environment;Epidemiology;Equity;Evaluation;evidence base;Evidence based practice;experience;Faculty;faculty support;Feedback;Fostering;Funding;Future Generations;Goals;health communication;health equity;Health Sciences;higher education;Immunology;improved;Individual;Infection;Institution;Institutional Policy;Institutionalization;Interdisciplinary Study;interest;Learning;learning progression;Logic;meetings;Mentors;Methods;Minority;Mission;model design;Modeling;Monitor;organizational climate;Outcome;Participant;Positioning Attribute;Privatization;Process;professor;Program Evaluation;programs;Public Health;recruit;Research;Science;skills;STEM career;success;synergism;System;Systems Biology;Teacher Professional Development;Testing;theories;Thinking;Underrepresented Populations;United States National Institutes of Health;Universities;Wages;Work

PROJECT_TITLE: Evaluation Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology;Nanotechnology;Prevention;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Biological processes are regulated through intricate signaling events that vary in time and 3D space (i.e., 4D). This project pioneers generalizable efforts to mimic, exploit, and quantify biology’s 4D complexity, paving the way to new therapeutic targets and treatments of disease through a fundamentally transformed knowledge of basic cell physiology. Critically, the methods being developed and implemented are cell-, tissue-, and disease- agnostic, enabling enhanced understanding of a wide variety of biological processes while laying the foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: DEFOREST, COLE A (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Area;Biochemical;Biocompatible Materials;Biological Markers;Biological Process;Biology;biophysical properties;Blood capillaries;Blood Vessels;Cardiovascular system;Cell Culture Techniques;Cell Physiology;Cells;Cues;Development;Disease;disease diagnosis;Disease Progression;drug action;Drug resistance;Endothelium;Event;Exhibits;Foundations;Hematological Disease;Heterogeneity;Homeostasis;Human;Hydrogels;In Vitro;in vivo;Knowledge;Life;Logic;Malignant Neoplasms;Maps;Methodology;Methods;migration;model organism;Morphogenesis;multidisciplinary;nanoparticle;new therapeutic target;Optics;Organ;Photochemistry;Physiological;Prevention;Process;programs;Proliferating;Proteins;Proteomics;Reporting;Research;Resolution;response;Sickle Cell Anemia;Signal Transduction;Signaling Protein;small molecule;spatiotemporal;Specificity;Therapeutic;Thrombosis;Time;Tissue Banks;Tissues;tool;tumor;Universities;Visualization;Washington

PROJECT_TITLE: Mimicking, Exploiting, and Understanding Biology's Heterogeneity in 4D

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: HUANG, HAILIANG  (contact)

PROJECT_TITLE: 1/4 Asian Bipolar Genetics Network (A-BIG-NET)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Primary Health Care;Rehabilitation;Serious Mental Illness;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed project will first develop a novel smartphone application (app) providing cognitive based therapy via the Mothers and Babies Program (MB) curriculum and then assess the feasibility and acceptability of utilizing the app as a study intervention in a randomized feasibility trial. The study app will contain on-demand education on postpartum health, breastfeeding; and infant milestones as well as interactive MB-based modules; those randomized to the control group will not access any MB content. Data obtained in the proposed trial will be critical for the design of a subsequent R01-supported randomized controlled trial, which will be fully powered to determine the effect of app-based MB on rates of postpartum depression among low-income, racially and ethnically diverse women at high risk for developing these conditions.

PI_NAMEs: LEWKOWITZ, ADAM KORRICK (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Affect;aged;American College of Obstetricians and Gynecologists;antenatal;Area;barrier to care;base;Behavior;Biometry;Birth;Breast Feeding;Cellular Phone;Child;Child Care;Childbirth;Childhood;Client satisfaction;Cognitive;cognitive development;Cognitive Therapy;Consent;Control Groups;Coping Skills;COVID-19 pandemic;Data;Depression screen;depressive symptoms;design;Development;Diagnosis;digital health;Disparity;Education;Educational Curriculum;Educational process of instructing;effective intervention;efficacy testing;Equity;ethnic diversity;Evaluation;experience;falls;feasibility trial;Feedback;Focus Groups;food insecurity;Funding;Goals;group intervention;health equity;Health Insurance;high risk;High Risk Woman;Impairment;implementation barriers;improved;improved outcome;Individual;Infant;Infant Care;innovation;innovative technologies;insight;Internet;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Low income;maternal morbidity;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Mothers;multidisciplinary;novel;obstetric outcomes;Outcome Study;Parenting Education;parenting intervention;patient oriented;patient oriented research;Perinatal;Perinatal Care;perinatal mental health;Persons;Phase;Physiological;pilot trial;Postpartum Depression;postpartum health;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention;Preventive;primary outcome;programs;Protocols documentation;prototype;Psychology;Questionnaires;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Risk Factors;screening;screening guidelines;secondary outcome;Services;smartphone application;Social support;Spanish;Spanish/English;structural determinants;Symptoms;System;Technology;technology intervention;telehealth;Testing;Text Messaging;Therapeutic Intervention;Time;tool;Training;Transportation;trial design;United States;United States National Institutes of Health;United States Preventative Services Task Force;Unmarried;usability;Visit;Woman;women of color;women's diagnosis

PROJECT_TITLE: A novel app-based cognitive behavioral therapy intervention for preventing postpartum depression

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Project Narrative Chronic kidney disease (CKD), which affects 37 million Americans, progresses with the loss of important proteins such as Klotho, leading to severe endocrine disease, as well as increased renal oxidative stress that further damages the kidneys. In this career development proposal, I will enhance my computational skills to identify how the interactions of Klotho and its ligand fibroblast growth factor 23 (FGF23) protect against oxidative stress at the molecular level. These studies will provide the backdrop for key career development as well as help to identify new pathways regulated by Klotho and FGF23 that may slow CKD progression, and potentially uncover novel therapeutic targets.

PI_NAMEs: AGORO, RAFIOU  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Active Learning;Acute;Adenine;Affect;American;Anemia;Antioxidants;Asthma;Automobile Driving;Binding;Binding Sites;Bioinformatics;bioinformatics resource;Bone Diseases;career;career development;Cells;Chromatin;Chromosomal Rearrangement;Chronic Kidney Failure;Communication;conditional knockout;Data;Data Analyses;Development Plans;Diet;Disease Progression;disorder risk;Distal;Doctor of Philosophy;Drug Metabolic Detoxication;Educational workshop;Elements;Endocrine System Diseases;Environment;Epidemic;Faculty;Fellowship;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Fostering;France;Genes;Genetic Polymorphism;genome-wide;genomic data;Genomics;Goals;Grant;Heme;heme oxygenase-1;Hormones;Human;Hypertension;Immunology;Impairment;improved;In Vitro;Indiana;Individual;Inflammation;Inflammatory;Injections;insight;interest;iron metabolism;Kidney;Kidney Diseases;Knockout Mice;Knowledge;Leadership;Learning;Ligands;LoxP-flanked allele;MAP Kinase Gene;Mediating;medical schools;meetings;Mentors;Minerals;Mitochondria;mitochondrial dysfunction;Modification;Molecular;mouse model;Mus;new technology;new therapeutic target;Nitrogen;novel;Occupations;overexpression;Oxidative Stress;Oxygen;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Phase;Phenotype;Positioning Attribute;Postdoctoral Fellow;Prevention;Production;promoter;Proteins;Proximal Kidney Tubules;Public Health;Reactive Oxygen Species;receptor;Renal function;Research;Research Activity;Research Personnel;response;Response Elements;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;skills;Stress;stress management;Testing;therapeutic target;Training;Training Activity;transcriptomics;Transgenic Mice;Transgenic Organisms;translational study;Tuberculosis;Universities;Vision;Wild Type Mouse;Work

PROJECT_TITLE: Controlling renal oxidative stress in CKD via targeting FGF23 bioactivity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]