NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE COPD is a leading cause of death worldwide and is linked to inflammation, yet the influence of fatty acid- derived compounds that resolve inflammation (called “SPMs”) on COPD outcomes is unknown. The proposed work, utilizing samples from the NIH BIOLINCC biospecimen repository, will allow for a deeper investigation into the role of SPMs in improving health disparities and outcomes in COPD. Findings from this study may ultimately lead to new therapeutic targets aimed at modulating inflammation in COPD.

PI_NAMEs: BOSE, SONALI  (contact);HANSON, CORRINE K

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Air Pollution;airway inflammation;American Lung Association;Anti-Inflammatory Agents;Asthma;Attenuated;Biological Markers;Biological Process;Biological Specimen Banks;Blood specimen;Bronchoconstriction;Cardiovascular Diseases;Cause of Death;CD59 Antigen;Cells;Chemical Exposure;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical practice;Clinical Trials;cohort;Cohort Studies;COVID-19;Data;deprivation;Development;Dietary Fatty Acid;Dietary intake;Disease;Disease Management;Disease Outcome;disease phenotype;Disease Progression;Disparity;Economics;Equilibrium;Ethnic Origin;Event;Exhibits;Fatty Acids;Future;Health;health disparity;high reward;Human;improved;Individual;Inequity;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;insight;Intervention;Investigation;Link;Lipids;Lipoxins;Losartan;loss of function;Lung;Lung Diseases;lung injury;Maintenance;Mediating;Mediator;Metabolic Diseases;Mission;Molecular;Morbidity - disease rate;mouse model;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Nutritional;Observational epidemiology;Omega-3 Fatty Acids;Outcome;Outcome Measure;Participant;Particulate Matter;Pathologic;Pathway interactions;Patients;personalized strategies;Phenotype;Plasma;Population;Population Heterogeneity;Prevention;Process;Production;promote resilience;public health intervention;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary Inflammation;Race;repaired;resilience;resilience factor;Resolution;respiratory;respiratory morbidity;Respiratory Signs and Symptoms;response;Risk;Risk Factors;Role;Sampling;Series;Severities;sex;Signal Transduction;Smoking;Symptoms;systemic inflammatory response;Testing;Therapeutic;therapeutic target;Tobacco;Tobacco smoke;Translations;trial design;Unhealthy Diet;United States National Institutes of Health;Validation;Virus;Vulnerable Populations;Work;Yin-Yang

PROJECT_TITLE: Role of specialized pro-resolving mediators of inflammation resolution in emphysema:  analyses of SPIROMICS and LEEP


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Hydrocephalus;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Pediatric hydrocephalus needs a new strategy to improve treatment outcomes. Our approach focuses on the development of a new non-surgical tool to control CSF production rate by inducing choroid plexus-specific apoptosis. The data gained in this research proposal will be directly applicable to developing additive therapy in shunt-treated neonatal hydrocephalus.

PI_NAMEs: GOTO, JUNE  (contact);MANGANO, FRANCESCO

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Ablation;adeno-associated viral vector;Adoptive Cell Transfers;Adult;Animal Behavior;Antigens;Apoptosis;autism spectrum disorder;Biological Assay;Biological Products;blood cerebrospinal fluid barrier;Brain;Brain Diseases;cancer therapy;CASP9 gene;Catalytic Domain;Cauterize;Cell Death;Cells;Cephalic;Cerebral Ventricles;Cerebrospinal Fluid;Childhood;Childhood Astrocytic Tumor;childhood epilepsy;Choroid Plexus Epithelium;Clinical;Coagulation Process;Creation of ventriculo-peritoneal shunt;Data;Dependence;Dependovirus;design;Development;Dimerization;Dose;Drug Kinetics;efficacy study;engineered T cells;Enzymes;Epithelial Cells;Excision;experience;Functional disorder;Funding Opportunities;Gene Expression;gene therapy;Genetic;Goals;Histology;Human;Hydrocephalus;immune cell infiltrate;Immunologics;improved;in vivo;Induction of Apoptosis;innovation;Insulin;Intracranial Pressure;Intraventricular;Magnetic Resonance Imaging;Measures;Mediating;Modeling;Mus;myelination;Neonatal;Nervous System Disorder;neuroinflammation;Neurologic;Neuromuscular Diseases;Neurosurgeon;neurosurgery;NIH Program Announcements;novel;novel therapeutics;Operative Surgical Procedures;Organ;Organoids;Outcome;Patients;Penetration;Peripheral;Phase;Procedures;Prodrugs;Production;promoter;Rattus;Recombinant adeno-associated virus (rAAV);Research Proposals;response;RNA;Rodent;Rodent Model;Safety;safety study;Serotyping;Shunt Device;Sirolimus;Specificity;Structure of choroid plexus;suicide gene;System;Techniques;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tissues;tool;Training;Transgenic Mice;translational study;Treatment Efficacy;Treatment outcome;Tropism;United States National Institutes of Health;Ventricular;Ventriculostomy;white matter injury;Work

PROJECT_TITLE: Novel Biologics to ablate choroid plexus for the treatment of neonatal hydrocephalus

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders—but this fear reduction is often transient and vulnerable to relapse. Stress undermines exposure therapy by disabling brain circuits critical for extinction learning. The long-term goal of this project is to understand the circuit and cellular mechanisms by which stress undermines extinction learning, a program of study that is essential for improving the long-term efficacy of exposure-based therapies .

PI_NAMEs: MAREN, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TITLE: Neural Circuits for Stress-Impaired Extinction Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project aims to pilot and assess an innovative, enhanced closed-loop health-related social needs (HRSN) screening and referral model designed to maximize the proportion of uncontrolled type 2 diabetes (T2DM) patients with HRSN who connect with and obtain resources from social service organizations to address those needs. The objectives of this proposal are consistent with the goals of the RFA-DK-22-038 to assess both the feasibility and acceptability of screening and implementing referral service linkages initiated within the context of the health care visit and assess the impact on both HRSN and T2DM outcomes. We expect that evidence generated from implementing and piloting this community-engaged, patient-centered model with form the basis for a fully powered study of this approach, contributing critical evidence for how safety-net health systems can advance health equity at the clinical, institutional, and community levels.

PI_NAMEs: BUITRON DE LA VEGA, PABLO ;DEDIER, JULIEN ;FISCHER, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: FLOURNOY FLOYD, MINNJUAN WYNCEPHEL

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Behavioral;biomedical referral center;Boston;Caring;Case Management;Characteristics;Clinic;Clinical;Clinical Data;clinical outcome measures;Communication;Communities;community engagement;Community Health Aides;Community Healthcare;community intervention;community partnership;Complex;Control Locus;Data;Data Analyses;Data Collection;diabetes control;diabetes management;Diabetes Mellitus;digital platform;Directories;Disparity;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Enhancement Technology;Ensure;Equity;Exhibits;experience;Foundations;Future;Glycosylated hemoglobin A;Goals;Health;Health Care Visit;health equity;health management;Health Status;Health system;Healthcare;Healthcare Systems;Hybrids;implementation cost;implementation evaluation;implementation framework;implementation outcomes;implementation strategy;improved;Individual;individual patient;Inequity;innovation;insight;Institution;Intervention;Joint Commission on Accreditation of Healthcare Organizations;Knowledge;Link;Medical;Medical center;model design;Modeling;Monitor;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;outreach;patient navigator;patient oriented;Patient Preferences;patient screening;Patient-Focused Outcomes;Patients;Penetration;person centered;Pilot Projects;population health;Primary Care;primary care clinic;primary care practice;Process;programs;Protocols documentation;Race;racial disparity;Randomized;Randomized, Controlled Trials;referral services;Resolution;Resource Allocation;Resources;safety net;screening;service organization;Services;Signal Transduction;Site;social;social capital;social service provider;Social Work;socioeconomic disparity;socioeconomics;standard of care;success;System;Technology;Testing;tool;Training;treatment and outcome;treatment as usual;Triage;trial design;web site;Work;working group

PROJECT_TITLE: THRIVE-DM: Improving Diabetes Care with Strategies for Addressing Health-Related Social Needs and Community Partnerships

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M2)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Microbiome;Neurodegenerative;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Loss of muscle and bone mass with age are underlying factors contributing to falls and fractures in the elderly, and these fractures are very costly in terms of both financial burden and quality of life. A critical barrier to progress in correcting the problem of muscle and bone loss with aging is a poor understanding of the molecular and cellular mechanisms underlying age-related musculoskeletal dysfunction. Our goal is to address this problem by providing critical, new information on the molecular and cellular mechanisms that control these processes, and thereby improve scientific knowledge, technical capability, and eventually clinical practice.

PI_NAMEs: FULZELE, SADANAND TUKDOJI;ISALES, CARLOS M. (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Age;age related;age related changes;Age-Related Bone Loss;Aging;Aryl Hydrocarbon Receptor;Automobile Driving;Autophagocytosis;Award;Bioinformatics;Biological Assay;Biometry;Body Composition;bone;bone cell;Bone Density;bone imaging;bone loss;Bone Marrow Stem Cell;bone mass;Cell Aging;clinical practice;Collaborations;Core Facility;cost;cytokine;Data;detection of nutrient;Development;Dual-Energy X-Ray Absorptiometry;Elderly;Enzymes;falls;Financial Hardship;Fracture;frailty;Functional disorder;functional outcomes;Funding;Gait;Goals;healthspan;Hip Fractures;improved;In Vitro;in vivo;Individual;Inflammaging;Inflammatory;Intervention;Knock-out;Knowledge;Kynurenine;Measures;Mechanics;Mediating;Medical Students;Mentors;microbiota;Mitochondria;Modeling;Molecular;Mus;Muscle;Muscle Cells;muscle form;muscle progenitor cell;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;Nuclear Receptors;Nutrient;older patient;Osteopenia;Osteoporosis;Pathway interactions;Phenotype;Play;prevent;Process;Productivity;programs;Puerto Rico;Quality of life;Receptor Activation;Receptor Cross-Talk;Receptor Signaling;receptor-mediated signaling;recruit;Research Personnel;Resources;sarcopenia;senescence;senescence associated secretory phenotype;Serum;sex;Sex Differences;skeletal;small molecule;stem cell function;stem cells;Testing;Tissues;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Work

PROJECT_TITLE: Microbiota-derived Tryptophan Metabolites in AD Pathophysiology


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Despite the observed epidemiological evidence linking fine particulate matter (PM2.5) exposures and Alzheimer’s Disease and related dementias (AD/ADRD), we still lack a deep understanding of the neurotoxicity of the specific PM2.5 components and the molecular mechanisms involved. By using innovative targeted and untargeted exposure assessment, single- and multi-omics analysis, and cross-tissue approaches, our primary objective is to offer valuable insights into how individual PM2.5 pollutants and mixtures interact with biological responses across epigenome, proteome, and metabolome, ultimately contributing to our understanding of AD/ADRD. This knowledge can aid future endeavors aimed at shaping environmental regulations and health policies to reduce the risk of AD/ADRD associated with air pollution.

PI_NAMEs: HUELS, ANKE  (contact);LIANG, DONGHAI ;WINGO, THOMAS SPURGEON

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Affect;African American;Age;Air Pollutants;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;ambient air pollution;Ammonium;Area;Autopsy;Biological;Biological Markers;Blood;Blood Circulation;Blood specimen;Brain;brain tissue;burden of illness;Carbon;Cerebrospinal Fluid;Chemicals;Chronic Disease;Clinical;Cognitive;cohort;Complex;Complex Mixtures;dementia risk;Development;development policy;Disease;DNA Damage;DNA Methylation;DNA Repair;Elements;endophenotype;Energy Metabolism;Enrollment;Environmental Health;Environmental Impact;Epidemiology;epigenome;epigenomics;Etiology;Exposure to;fine particles;follow-up;Functional disorder;Future;Gases;Genetic;Genetic Risk;Health;Health Policy;Human;Impaired cognition;Individual;innovation;insight;Intervention;Knowledge;Link;Location;Longitudinal cohort study;Maps;Measurement;Measures;Mediating;metabolome;metabolomics;Metals;meter;Modeling;Molecular;Molecular Profiling;multiple omics;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuroinflammation;neuropathology;neurotoxic;neurotoxicity;Nitrates;novel;Olfactory Nerve;Oxidative Stress;Participant;particle;Particulate Matter;Pathway interactions;Pattern;Phenotype;Plasma;pollutant;Prevention strategy;prospective;Prospective, cohort study;Proteins;Proteome;Proteomics;racial diversity;Regulation;Research;Resolution;Respiratory System;response;Risk;Risk Reduction;Role;Senile Plaques;Shapes;spatiotemporal;Sulfate;Time;Tissues;Toxic Environmental Substances;toxicant;Visit

PROJECT_TITLE: IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and their Contribution to Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Mutations in a mitochondrial protein, coiled helix coiled helix domain containing protein 10 (CHCHD10), cause frontotemporal dementia and amyotrophic lateral sclerosis. This project studies the mechanisms leading to disease in CHCHD10 mutations and therapeutic strategies to treat these disorders, using animal and cellular models.

PI_NAMEs: ELIEZER, DAVID ;FUJITA, HIBIKI  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affect;ALS pathology;Alzheimer's Disease;Amyloid;Amyloid Fibrils;amyloid formation;Amyotrophic Lateral Sclerosis;Animal Model;Antisense Oligonucleotides;Attenuated;Autophagocytosis;Autopsy;Biochemical;Bioenergetics;biological adaptation to stress;Brain;Cardiomyopathies;Cell model;Cells;Cellular Stress;clinical development;Collaborations;Data;Defect;Dementia;Deposition;Disease;disease phenotype;Encephalopathies;Exhibits;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;genetic approach;Genetic Transcription;Goals;High Fat Diet;Human;improved;In Vitro;in vivo;Knock-in Mouse;Knockout Mice;Knowledge;Link;lipid metabolism;loss of function;Mediating;Membrane;Metabolic;Metabolic Pathway;metabolomics;Mitochondria;mitochondrial autophagy;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Molecular;monomer;mouse model;mTOR inhibition;Mus;mutant;Mutant Strains Mice;Mutation;Myopathy;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurologic Symptoms;neuropathology;neuroprotection;Outcome;Parkin;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peripheral;Pharmacologic Substance;Phenotype;pre-formed fibril;Prions;Process;programs;promoter;Property;protective effect;protein aggregation;Protein Biochemistry;protein folding;protein structure;Proteins;proteostasis;proteotoxicity;Quality Control;Reporting;Resolution;Sampling;Sirolimus;Stress;Structure;subcutaneous;System;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Tissues;ubiquitin-protein ligase

PROJECT_TITLE: CHCHD10 Frontotemporal Dementia, Molecular Mechanisms and Therapeutic Strategies

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Palliative Care;Primary Health Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative: Older adults with serious illness have high rates of anxiety and depression not well addressed by current paradigms of care. This study aims to implement Collaborative Care, a model of mental health care integrated in medical care, in the palliative care setting to improve the treatment of depression and anxiety among older adults with serious illness. This work will lead the way to sustainable, scalable approaches to improving mental health care in the medical treatment of older adults.

PI_NAMEs: SHALEV, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;adjudication;Aging;American;Anxiety;arm;Award;Behavior Therapy;Behavioral;behavioral clinical trial;career;career development;Caregiver support;Caregiver well-being;Caregivers;Caring;Cessation of life;Chronic Disease;Chronic lung disease;Clinic;clinical care;clinical training;Clinical Trials;collaborative care;community engagement;comorbid depression;Consultations;Data;depression model;design;Development Plans;Diagnosis;Diagnostic;direct patient care;Disease;efficacy trial;Elderly;end of life care;experience;Face;falls;Feedback;flexibility;Funding;Geriatric Assessment;geriatric mental health;Geriatrics;Goals;Grant;Health Services for the Aged;Heart failure;Home;Hospice Care;hospital care;Hospitals;implementation science;improved;integrated care;interdisciplinary approach;Intervention;Intervention Studies;Knowledge;Leadership;Life;Loneliness;longitudinal care;Malignant Neoplasms;Measures;Medical;Medicine;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Modeling;multidisciplinary;multiple chronic conditions;older adult;Older Population;Oncology;Outcome;Palliative Care;Palliative Medicine;Patients;Phase;pilot test;Polypharmacy;Primary Care;primary outcome;professor;Prognosis;programs;psychiatric symptom;Psychiatrist;Psychiatry;psychological symptom;Quality of life;Randomized, Controlled Trials;Recommendation;reduce symptoms;referral services;Research;Research Personnel;Research Training;satisfaction;Schedule;secondary outcome;Self Efficacy;Site;skills;Social isolation;Social Work;Social Workers;Societies;Specialist;standard of care;Symptom Burden;Symptoms;therapy design;Training;treatment as usual;treatment duration;trend;United States;Work;Writing

PROJECT_TITLE: CoCM-PAL: Adapting Collaborative Care for Older Adults with Serious Illness and Comorbid Depression or Anxiety Receiving Ambulatory Palliative Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Prevention;Sleep Research

PHR: NARRATIVE: A large percentage of children with Down Syndrome (DS) have obstructive sleep apnea (OSA) that is suboptimally treated by first-line surgical interventions. The persistence of OSA-related nightly intermittent hypoxemia and fragmented sleep may contribute to a cognitive impairment, reduced daily functional impairment as well as pulmonary vascular disease and myocardial dysfunction. We propose a randomized trial of oxygen therapy to treat obstructive sleep apnea.

PI_NAMEs: AMIN, RAOUF S. (contact);REDLINE, SUSAN S.

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: 17 year old;actigraphy;Address;Adolescent;Age;Agitation;Air;airway obstruction;Algorithms;Anatomy;Apnea;arm;Arousal;Attenuated;Behavior;Cardiac;Caregivers;Characteristics;Child;Childhood;Clinical;clinical research site;Clinical Trials;cognitive function;comparison control;Compensation;Continuous Positive Airway Pressure;craniofacial;Data;Data Coordinating Center;data handling;data quality;design;Dilator;Dose;Down's Syndrome;Early identification;Echocardiography;efficacious treatment;Enrollment;Equipment and supply inventories;executive function;experience;Family;Functional impairment;health assessment;health related quality of life;heart function;high risk;Hippocampus;Hour;Hypoxemia;Hypoxia;Impaired cognition;Impairment;improved;indexing;Individual;Injury;Knowledge;Laboratories;Left Ventricular Function;mathematical model;Measures;Methods;Monitor;Muscle;Muscle Tonus;Myocardial;Myocardial dysfunction;Neurocognition;Neurocognitive;neurocognitive test;normoxia;Nose;novel;Obesity;Obstructive Sleep Apnea;Operative Surgical Procedures;Outcome;Outcome Measure;Oxygen;Oxygen Therapy Care;Participant;patient population;patient subsets;Patients;Performance;pharynx muscle;Phase;Physiologic intraventricular pressure;Physiological;Physiology;Population;precision medicine;Prefrontal Cortex;prevent;primary endpoint;primary outcome;Process;Protocols documentation;pulmonary arterial pressure;pulmonary vascular disorder;Quality Control;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;Reflex action;Reporting;response;Right Ventricular Function;Safety;Sampling;secondary outcome;Severities;Short-Term Memory;Sleep;Sleep disturbances;Sleep Fragmentations;sleep health;Structure;Supervision;supplemental oxygen;Supplementation;Testing;Therapeutic;Time;Titrations;Ventricular Function;Weight maintenance regimen

PROJECT_TITLE: Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(90)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Food insecurity disproportionately affects those who have been historically marginalized and significantly contributes to poor health outcomes. Increasing awareness and access to programs that promote food equity by providing affordable healthy produce is a promising way to improve health outcomes and empower patients and communities to achieve better health and well-being. The goal of this proposal is to refine and optimize implementation strategies that connect families to food security nutrition support programs through medical clinics, and improve communication between the healthcare and healthy food access systems to support greater patient autonomy and self-efficacy to obtain, prepare, and consume healthy foods.

PI_NAMEs: RHEE, KYUNG E (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Administrator;Adoption;Affect;Awareness;bilingualism;Blood Pressure;California;Caring;Characteristics;Child;Child Nutrition;Chronic;Clinic;Clinical;Communication;Communities;Consumption;Counseling;delivered meals;design;Diabetes Mellitus;Dietitian;Dose;Economics;Education;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Electronic Health Record;empowerment;Environment;Equity;experience;Family;Family health status;follow up assessment;Food;Food Access;food insecurity;food security;Fruit;fruits and vegetables;Funding;Gastroenterology;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care quality;health care settings;health equity promotion;Health Food;Health Personnel;Health system;Healthcare;Healthcare Systems;Healthy Eating;Home;Housing;Hunger;implementation determinants;implementation evaluation;implementation outcomes;implementation process;implementation strategy;improved;Incentives;Insulin;Insurance;Intake;Lipids;Liver diseases;Liver Function Tests;marginalization;Medicaid;Medical;Medicare/Medicaid;member;Metabolic dysfunction;Metformin;Modification;Neighborhoods;nutrition;nutrition education;Nutritional;Outcome;Patients;Pediatric Hospitals;Personal Satisfaction;Pharmaceutical Preparations;Policies;Policy Maker;poor health outcome;Process;Program Effectiveness;Program Sustainability;programs;Provider;Public Health;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;screening;Self Efficacy;Services;social health determinants;Social Work;Social Workers;socioeconomics;Stress;Structure;success;symposium;System;Testing;Transportation;type I and type II diabetes;United States Department of Agriculture;Weight;Work

PROJECT_TITLE: Addressing Food Insecurity in the Health Care Setting to Promote Health Equity


NIH_SPENDING_CATS: Biomedical Imaging;Complementary and Integrative Health;Hyperbaric Oxygen;Lung;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This proposal tests the hypothesis that exposure to brief periods of 100% oxygen will have an anti- inflammatory impact on the injured cervical spinal cord. We further hypothesize that combining 100% oxygen therapy with treatment with a perfluorocarbon molecule will result in neuroprotection as shown by reduced loss of neurons after spinal cord injury. We predict that this will improve breathing ability after cervical spinal cord injury.

PI_NAMEs: BOSE, PRODIP K.;FULLER, DAVID D (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Anesthesia procedures;Anti-Inflammatory Agents;Astrocytes;Attenuated;Blood;Blood flow;Breathing;Cells;Cervical;Cervical spinal cord injury;Cicatrix;Control Groups;Contusions;Coupled;Data;Drops;Evaluation;experimental study;Exposure to;Flow Cytometry;Fluorocarbons;Histologic;Hour;Hyperbaric Oxygen;Hyperbaric Therapy;Hyperoxia;Hypoxia;image visualization;Immunohistochemistry;Impairment;improved;in vivo;Inflammation;Injury;innovation;Interruption;Lesion;Magnetic Resonance Imaging;Measurement;Measures;Methods;Microglia;Modeling;Molecular;Motor Pathways;nano;Necrosis;Nerve Degeneration;neural tract;Neuroglia;neuroinflammation;neuromuscular system;neuron loss;Neuronal Plasticity;Neurons;neuroprotection;next generation;Outcome;Outcome Measure;Output;Oxygen;Oxygen Therapy Care;Partial Pressure;Persons;Plasma;preservation;pressure;Qualifying;Quality of life;Rattus;Recovery;Research;Resolution;respiratory;Respiratory Diaphragm;response;Solubility;Spinal;Spinal cord injury;Structure of phrenic nerve;Testing;therapeutically effective;Tissues;tractography;treatment duration;Work

PROJECT_TITLE: Normobaric Oxygen Therapy for Spinal Cord Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-M (03)]


ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative The proposed research is relevant to public health because it explores development of new approaches to target injured neurons for the treatment of brain disorders, with a focus on seizures and epilepsy. The proposal develops a nanotechnology-based approach that targets the increased activity of neurons during seizures to deliver drugs specifically to them, thereby increasing drug efficacy and reducing side effects. Therefore, this work is relevant to the mission of NIH relating to treating neurological disorders.

PI_NAMEs: KANNAN, SUJATHA ;RANGARAMANUJAM, KANNAN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Address;Affect;Affinity;Antibodies;Area;Attenuated;Avidity;bench-to-bedside translation;Binding;Biodistribution;Brain;brain cell;Brain Diseases;Brain Injuries;Brain region;Central Nervous System Diseases;Chemistry;chronic pain;Clinical;clinically relevant;cyanine dye 5;Data;Dendrimers;design;Development;Dose;Drug Delivery Systems;drug efficacy;Drug Kinetics;efficacy evaluation;Epilepsy;excitotoxicity;experimental study;Formulation;Generations;Glucose;glucose metabolism;glucose transport;Glucose Transporter;glucose uptake;Goals;Hydroxyl Radical;Image;In Vitro;in vivo;in vivo Model;inhibitor;injured;Injury;injury and repair;Intracellular Transport;Ketamine;Label;Ligands;Ligation;Longitudinal Studies;Macrophage;Measures;Metabolic;Microglia;Mission;Modeling;mouse model;nanomaterials;nanomedicine;Nanotechnology;Nervous System Disorder;Nervous System Trauma;neuroinflammation;neuron loss;Neuronal Injury;Neurons;neuroprotection;Neurosciences;novel;novel strategies;Organ;Parkinson Disease;Pathologic;Pathology;Patients;Phagocytes;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Phosphorylation;Pilocarpine;Positron-Emission Tomography;preservation;prevent;Proteins;Public Health;Radioactivity;Rattus;Research;response;Risk;Rodent;Rodent Model;Seizures;Serum;side effect;SLC2A1 gene;Specificity;Status Epilepticus;Stroke;Surface;Testing;Therapeutic;Tissues;Transgenic Mice;Trauma;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Novel Glucose dendrimers for targeting injured neurons

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Racial and ethnic minorities with chronic kidney disease are more likely to progress to end-stage kidney disease, to be disproportionately burdened by health-related social needs, and to receive suboptimal transitional care including less initiation of home dialysis therapies. This application tests the feasibility, acceptability, and possible effect of multipronged intervention to address both care delivery and social risk factors that undermine home dialysis uptake in minority populations. The results will be used to inform further studies in care delivery to reduce health inequities in home dialysis use and improve the quality of life for patients with chronic kidney disease.

PI_NAMEs: JOHNS, TANYA  (contact);MELAMED, MICHAL L

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult;African American;American;arm;Black Populations;Black race;care coordination;care delivery;Caring;Chronic Care;Chronic Kidney Failure;Clinic;Clinical;clinical effect;community advisory board;community engaged approach;community engaged research;Community Health Aides;community partners;Dialysis procedure;Dimensions;Disparity;Education;Effectiveness;End stage renal failure;Enrollment;ethnic disparity;ethnic minority;experience;feasibility testing;Fibrinogen;financial toxicity;food insecurity;Fostering;Goals;Health;health equity;health inequalities;Health system;Healthcare;Hispanic;Hispanic Populations;Home;Home Hemodialysis;Hospitals;Housing;implementation determinants;improved;Institution;Intervention;Interview;Kidney;Latinx;Link;Lived experience;Measures;Medical;member;Minority;Minority Groups;Modality;motivational enhancement therapy;multi-component intervention;Nephrology;Nurse Practitioners;Outcome;Outpatients;Participant;patient engagement;Patients;peer support;Peritoneal Dialysis;Population;primary care setting;Process;Provider;Qualifying;Quality of life;Questionnaires;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Resources;Risk Factors;Sampling;secondary outcome;social;social health determinants;Social support;Social Work;Standardization;Structure;System;Techniques;Therapeutic;Training;Transplantation;Transportation;trial design;Trust;uptake;willingness;Work

PROJECT_TITLE: Community Health Workers in an Interdisciplinary Outpatient CKD Clinic to Optimize Social Care Navigation, Patient Engagement, and Home Dialysis Utilization- the CHOOSE Home trial


ADMINISTERING_IC: AR

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The ability of muscle and other tissues to respond to internal and external mechanical forces with the expression of specific genes that allow cells to adapt to their dynamic environment is critical for the development, maintenance, and function of these tissues. Building on recent findings that indicate that the cell nucleus itself contributes to cellular mechanotransduction, the studies proposed in this application will determine the molecular mechanisms responsible for the rapid expression of mechanoresponsive genes upon mechanical stimulation, define the role of nuclear envelope proteins involved in the force transmission between the cytoskeleton and nucleus in this process, and assess the functional consequences of impaired nuclear mechanotransduction in skeletal muscle. Insights gained from these studies will be critical to the development of new targeted therapeutic approaches for muscular dystrophy and other diseases caused by perturbed cellular mechanotransduction.

PI_NAMEs: LAMMERDING, JAN  (contact);LIS, JOHN T

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Base Pairing;Biochemical;Biological Assay;Cell Nucleus;Cell surface;cell type;Cells;Characteristics;Complex;Cytoplasm;Cytoskeleton;Data;Defect;Detection;Development;differentiation in vitro;Disease;disease-causing mutation;env Gene Products;Environment;Event;experimental study;Exposure to;FASTK Gene;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Heart Diseases;Human body;Impairment;In Vitro;in vivo;insight;Intervention;Knowledge;Lamins;Lead;Maintenance;Maps;mechanical force;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanical Stress;Mechanics;mechanotransduction;Medical;Molecular;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;Muscular Dystrophies;Mutation;Myocardium;Myopathy;new therapeutic target;novel;Nuclear;Nuclear Envelope;Nuclear Structure;Pathology;Pathway interactions;Physical environment;Physiology;Polymerase;Process;Proteins;rapid detection;Regulation;Regulator Genes;Research;Resolution;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Skin;Structure;System;Techniques;Time;Tissues;tool;transcription factor;Translating;transmission process;Work

PROJECT_TITLE: Defining nuclear mechanisms for ultrarapid mechanically induced gene expression

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Kidney Disease;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN) are rare glomerular diseases that cause serious morbidity including kidney failure and high mortality, generating enormous individual and societal burden. CureGN has assembled nephrologists, scientists with broad expertise, and patients in a consortium that will maintain and analyze a large, longitudinal observational data set and biorepository. This broad effort provides a critical infrastructure that will advance our ability to study, classify, characterize, diagnose, and treat primary glomerular diseases of the kidney.

PI_NAMEs: HOLZMAN, LAWRENCE B. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Achievement;actionable mutation;Address;Adult;Advocacy;Affect;Ancillary Study;APOL1 gene;biobank;Biocompatible Materials;Biology;biopharmaceutical industry;Biopsy;Blood;career development;Caring;Child;Childhood;Classification;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;community engagement;Consultations;Data;Data Collection;data collection methodology;Data Coordinating Center;Data Set;Databases;Development;Diagnosis;digital pathology;Disease;Disease remission;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Epigenetic Process;Etiology;Focal and Segmental Glomerulosclerosis;follow-up;Formalin;Fostering;Funding;Funding Agency;Future;Genetic;genome sequencing;Goals;Grant;handheld mobile device;Health Technology;Heterogeneity;high risk;high standard;IGA Glomerulonephritis;Immunologics;improved;Individual;Industry;industry partner;Infrastructure;innovation;International;Investigation;Kidney Diseases;Kidney Failure;Knowledge;Longitudinal, observational study;Medical Record Linkage;Membranous Glomerulonephritis;metabolomics;Methods;mHealth;Michigan;Mission;Modernization;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;Natural History;Nephrology;next generation;North Carolina;novel;observational cohort study;Observational Study;Outcome;Output;outreach;pandemic disease;Paraffin Embedding;Participant;participant retention;Pathogenesis;Pathology;patient advocacy group;patient engagement;Patient Outcomes Assessments;Patient Participation;Patients;Pattern;Pennsylvania;personalized care;Persons;Phase;Pilot Projects;Population;precision medicine;predict clinical outcome;Procedures;Process;Productivity;Professional Organizations;Prognosis;programs;prospective;Protocols documentation;Publications;Publishing;recruit;Renal glomerular disease;repository;Research;Research Personnel;risk variant;Role;sample collection;Sample Size;Science;Scientist;Services;Site;social;social health determinants;Standardization;Statistical Data Interpretation;Structure;Time;Tissue Embedding;tool;Training;transcriptome sequencing;Translational Research;treatment response;treatment strategy;Universities;Visit;whole genome;Work;working group

PROJECT_TITLE: CureGN-Penn PCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: Boulder

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project directly addresses the family planning objectives of Healthy People 2030. It does so by investigating the impact of decreased access to contraception in Texas on fertility, especially of young women, and on women’s later economic outcomes and human capital accumulation. Its results will contribute to establishing evidence-based policies to promote health.

PI_NAMEs: STEVENSON, AMANDA JEAN (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Affect;Age;age related;American;Birth;Caring;Censuses;Cessation of life;Childhood;Clinic;Code;Colorado;Community Surveys;Contraception Behavior;Contraceptive Agents;Contraceptive methods;Data;data centers;Dedications;economic impact;economic outcome;Education;Employment;Enrollment;Ethnic Origin;evidence base;Exclusion;experience;experimental study;Exposure to;Family;Family Planning;Fertility;Funding;Geographic Locations;Grant;Health Promotion;Healthcare Systems;Heterogeneity;Hormonal;Household;human capital;improved;Income;Individual;Investments;Journals;Labor Forces;Life Cycle Stages;Link;Location;longitudinal dataset;Longitudinal Surveys;Measures;Mediating;meetings;Methods;National Institute of Child Health and Human Development;Natural experiment;Outcome;Paper;parity;Pathway interactions;Persons;Policies;Poverty;prevent;programs;Proliferating;Provider;Quasi-experiment;Race;Reproduction;reproductive;Research;Research Personnel;response;social norm;Social outcome;Socioeconomic Status;socioeconomics;Source;Surveys;Taxes;teenage fertility;Testing;Texas;United States;Update;US State;Woman;young woman

PROJECT_TITLE: Life course impacts of reduced access to contraception

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE The timing and sequence of animal development are genetically controlled. While many genes identified in model organisms have been found to play conserved roles in organizing the sequence of developmental progression in all animals, we still have a limited understanding of how the precise timing of developmental gene expression is accomplished. Using biochemical, structural, and genetic approaches, experiments outlined in this proposal aim to characterize a novel biological clock that directly coordinates the timing and output of key developmental miRNA genes during animal growth.

PI_NAMEs: HAMMELL, CHRISTOPHER MARTIN (contact);JOSHUA-TOR, LEEMOR

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Affinity;Agonist;Alleles;Animals;Binding;Biochemical;Biochemistry;Biological Assay;Biological Clocks;Caenorhabditis elegans;cell fate specification;Cell Lineage;Cells;Characteristics;Cholesterol;circadian;circadian pacemaker;Complex;Cryoelectron Microscopy;Defect;design;Development;Developmental Gene;DNA;DNA Binding;Docking;dosage;Engineering;Exhibits;experimental study;Family member;Feedback;gain of function;Gene Expression;gene regulatory network;Generations;Genes;Genetic;genetic analysis;genetic approach;Genetic Complementation Test;Genetic Transcription;Growth;Heme;Heterodimerization;Hormonal;imaging platform;imaging system;In Vitro;in vivo;Knowledge;Libraries;Ligands;Lobular Neoplasia;loss of function;Measures;Mediating;Messenger RNA;Metabolic;Microfluidics;MicroRNAs;model organism;Molecular;molecular clock;Monitor;mutant;Mutation;Nematoda;novel;Nuclear Hormone Receptors;Orthologous Gene;Output;Pattern;Periodicals;Phase;Play;Postembryonic;posttranscriptional;Process;programs;protein complex;protein function;Proteins;Regulatory Element;Reproducibility;Resolution;Role;stem cell division;Structure;Surface;System;Time;Tissues;Trans-Activators;transcription factor;Transcriptional Activation;transcriptome;Visualization;X-Ray Crystallography

PROJECT_TITLE: Molecular timekeeping and temporal cell fate specification in C. elegans

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE We propose using exceptional resources and cutting-edge technologies to conduct the first proteogenomics study and the first prospective breast tissue-based nested case-control proteomics study to discover and validate breast cancer risk proteins. The biological functions of promising proteins will be further evaluated by a series of bioinformatics analyses and in vitro functional assays. Successful completion of this proposed study will unveil causal protein candidates for future mechanistic research, improve our understanding of the biological basis for breast cancer, and have important implications for disease prevention and treatment for this common malignancy.

PI_NAMEs: LONG, JIRONG  (contact);SHU, XIAO-OU

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Affect;African ancestry;Age;Asia;Asian ancestry;Atlases;biobank;Bioinformatics;Biological;Biological Assay;Biological Process;Biometry;Breast;Breast Cancer cell line;Breast Cancer Genetics;Breast Cancer Risk Factor;Cancer Biology;Carcinoma;case control;causal variant;Cell Physiology;cell type;Cells;Clinical;Clinical Data;cohort;Collaborations;common treatment;cost;cost efficient;Data;Diagnostic;Disease;disorder prevention;disorder risk;Epidemiology;European;follow-up;Foundations;Freezing;Future;gene product;Genes;Genetic;genetic predictors;Genetic study;genetic variant;genome wide association study;genomic data;genomic locus;Genomics;Genotype-Tissue Expression Project;Goals;Human;improved;In Vitro;Incidence;indexing;Individual;innovation;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Gland Parenchyma;Mass Spectrum Analysis;Messenger RNA;Modeling;multiple reaction monitoring;Nested Case-Control Study;novel;novel strategies;Pathogenesis;Pilot Projects;Play;Post-Translational Regulation;predictive modeling;Prevention;prospective;Proteins;proteogenomics;Proteome;Proteomics;Publications;Race;racial population;Research;Resources;risk variant;RNA;Role;Sampling;Series;statistics;Technology;Testing;Tissue Banks;Tissue Donations;Tissue Sample;transcriptome;Translating;Translations;tumor;Woman

PROJECT_TITLE: Identification of proteins for breast cancer risk: an integrative epidemiologic and genomic study

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: LAY NARRATIVE MCD, FSGS, MN, and IgAN are rare glomerular diseases of the kidney that cause serious illness including kidney failure and high mortality, generating enormous individual and societal burden. CureGN has assembled nephrologists, researchers with expertise in different scientific disciplines, and patients in a consortium that maintains and analyzes a large, longitudinal observational data and biosamples like blood, urine and images of kidney biopsies. This initiative has developed a critical infrastructure that will advance our ability to study, classify, characterize, diagnose, and treat primary glomerular diseases of the kidney.

PI_NAMEs: BOMBACK, ANDREW STEPHEN (contact);GHARAVI, ALI G;KIRYLUK, KRZYSZTOF

PROJECT_TERMS: Acceleration;Achievement;actionable mutation;Address;Adult;Advocacy;Affect;Ancillary Study;APOL1 gene;biobank;Biocompatible Materials;Biology;biopharmaceutical industry;Biopsy;Blood;career development;Caring;Child;Childhood;Classification;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;community engagement;Consultations;Data;Data Collection;data collection methodology;Data Coordinating Center;Databases;Development;Diagnosis;digital pathology;Discipline;Disease;Disease remission;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Epigenetic Process;Etiology;Focal and Segmental Glomerulosclerosis;follow-up;Formalin;Fostering;Funding;Funding Agency;Future;Genetic;genome sequencing;Goals;Grant;handheld mobile device;Health Technology;Heterogeneity;high risk;high standard;IGA Glomerulonephritis;Immunologics;improved;Individual;Industry;industry partner;Infrastructure;innovation;International;Investigation;kidney biopsy;Kidney Diseases;Kidney Failure;kidney imaging;Knowledge;Longitudinal, observational study;Medical Record Linkage;Membranous Glomerulonephritis;metabolomics;Methods;mHealth;Michigan;Mission;Modernization;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;Natural History;Nephrology;next generation;North Carolina;novel;observational cohort study;Observational Study;Outcome;Output;outreach;pandemic disease;Paraffin Embedding;Participant;participant retention;Pathogenesis;Pathology;patient advocacy group;patient engagement;Patient Outcomes Assessments;Patient Participation;Patients;Pattern;Pennsylvania;personalized care;Persons;Phase;Pilot Projects;Population;precision medicine;predict clinical outcome;Procedures;Process;Productivity;Professional Organizations;Prognosis;programs;prospective;Protocols documentation;Publications;Publishing;recruit;Renal glomerular disease;repository;Research;Research Personnel;risk variant;Role;sample collection;Sample Size;Science;Scientist;Services;Site;social;social health determinants;Standardization;Statistical Data Interpretation;Structure;Time;Tissue Embedding;tool;Training;transcriptome sequencing;Translational Research;treatment response;treatment strategy;Universities;Urine;Visit;whole genome;Work;working group

PROJECT_TITLE: The Columbia PCC for CureGN: the Cure Glomerulonephropathy network


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Disability Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: Narrative Schizophrenia is a major neuropsychiatric disorder associated with long-term disability and excess mortality. Large-scale brain imaging data sets capable of addressing the underlying causes and identifying novel treatment approaches are lacking. This study leverages the ongoing NKI Rockland Sample II study to collect a large-scale multimodal imaging data set in schizophrenia which will be shared on-line to allow open investigation into causes and consequences of brain imaging abnormalities in schizophrenia.

PI_NAMEs: JAVITT, DANIEL C. (contact);MARTINEZ, ANTIGONA

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Achievement;Address;Affect;Age;age related;Aggressive behavior;Algorithms;Behavior;Behavior assessment;Behavioral;Brain;brain dysfunction;brain health;Brain imaging;cardiovascular fitness;Caring;Chronology;Clinical;clinical investigation;Cognition;Cognitive;cognitive function;cognitive performance;cognitive task;Collection;Communities;Companions;comparative;County;Data;data archive;Data Reporting;Data Set;data sharing;Databases;design;Development;Diabetes Mellitus;Diffusion;Dimensions;disability;Disability Evaluation;Disease;Distress;Ecological momentary assessment;Electroencephalography;Event;Event-Related Potentials;Excess Mortality;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;functional outcomes;Funding;Goals;Health;health data;Human;human very old age (85+);Hypertension;Image;imaging approach;imaging system;Impaired cognition;Impairment;improved;Impulsivity;Individual;informant;insight;International;Investigation;Investments;large datasets;large scale data;Libraries;Life;life span;Life Style;Loneliness;Long term disability;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Measurement;Measures;Mental disorders;Mental Health;Methods;Morbidity - disease rate;mortality;multimodal data;Multimodal Imaging;multimodality;National Institute of Mental Health;neural;Neurocognitive;neuroimaging;neuromechanism;neuromelanin;neurophysiology;neuropsychiatric disorder;neuropsychiatry;New York;novel;Obesity;Occupational;open data;Outcome;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phenotype;phenotypic data;Physiological;Physiology;Population;Procedures;Process;prospective;Proxy;Psychopathology;recruit;Resources;Rest;Risk;Risk Factors;sample fixation;Sampling;satisfaction;Schedule;Schizophrenia;Scientific Advances and Accomplishments;sensor;Sensory;severe mental illness;Signal Transduction;skills;smartphone application;social;Social outcome;suicidal;suicide rate;Symptoms;Technology;United States National Institutes of Health;Vision;visual tracking;wearable device

PROJECT_TITLE: A  Schizophrenia Extension Study for the NKI Rockland Sample II project: An Open Resource of Multimodal Brain, Physiology & Behavior from a Community Lifespan Sample

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE This project investigates the impact of sleep disturbances and physical frailty on the cognitive progression of older adults with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), as well as the moderating effect of physical frailty on the relationship between sleep disturbances and cognitive outcomes. By exploring these factors, the study aims to shed light on the mechanisms underlying the conversion from SCD/MCI to Alzheimer’s Disease and Related Dementias (ADRD). The findings will help to identify vulnerable populations and proposing public health strategies for delaying or preventing ADRD progression in SCD and MCI cohorts, with a focus on sleep and physical frailty.

PI_NAMEs: HUANG, JING  (contact)

PROJECT_TERMS: Acceleration;actigraphy;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Award;biobank;Brain;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;computerized;Data;Dementia;Diagnosis;Disease Progression;Drowsiness;frailty;Future;Goals;Growth;Health;Health and Retirement Study;high risk;high risk population;Hospitals;Impaired cognition;Incidence;Individual;lens;Literature;Magnetic Resonance Imaging;Measures;Meta-Analysis;mild cognitive impairment;Modeling;mortality;neuroimaging;older adult;Outcome;Patient Self-Report;Phase;poor sleep;Population;Populations at Risk;Postdoctoral Fellow;pre-clinical;prevent;Public Health;Records;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk sharing;Role;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep onset;Sleeplessness;Structure;Symptoms;Testing;Training;Vulnerable Populations

PROJECT_TITLE: Cognitive progression among older adults with subjective cognitive decline and mild cognitive impairment: the roles of sleep and physical frailty

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Albany

ORG_NAME: REGENERATIVE RESEARCH FOUNDATION

PHR: Alzheimer’s disease- and related dementias typically show pathological changes in the cerebral cortex, affecting brain and vascular cells. Mutations in PSEN1 are the most common cause of early onset, heritable Alzheimer’s disease. We will construct a 3D human stem cell model in tissue culture that will include the major cell types affected in patients carrying PSEN1 mutations and test whether the model shows key features of patient pathology. The goal is to develop a reliable and reproducible model that leads to a greater understanding of disease mechanism and improves our ability to predict the safety and efficacy of candidate drugs.

PI_NAMEs: TEMPLE, SALLY  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3-Dimensional;Achievement;Adoption;Aducanumab;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Animal Model;Antibodies;Antibody Therapy;Astrocytes;autosomal dominant Alzheimer's disease;Binding;Biological;Blood Vessels;Brain;brain tissue;Cell Line;Cell Lineage;cell type;Cells;Cerebral Amyloid Angiopathy;Cerebral cortex;cerebral vascularization;Cerebrospinal Fluid;cerebrovascular;Cerebrum;Characteristics;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Conditioned Culture Media;Confounding Factors (Epidemiology);Data;Data Set;Development;Disease;disease-causing mutation;donor stem cell;drug candidate;early onset;Elements;Endothelial Cells;Engineering;evaluation/testing;Face;Family;Gene Expression;Genetic;Glial Differentiation;Goals;Growth;Hemorrhage;Heritability;Human;human disease;human induced pluripotent stem cells;human stem cells;hydrogel scaffold;Hydrogels;hyperphosphorylated tau;improved;in vivo;Induced Mutation;induced pluripotent stem cell;insight;Institution;Knock-in Mouse;Laboratories;Light;lipidomics;macroglia;Measures;Mesoderm;metabolomics;Methods;Microglia;Modeling;mouse model;mutant;Mutate;Mutation;mutation carrier;National Institute of Neurological Disorders and Stroke;Neural Crest;neurodegenerative phenotype;neurofilament;Neuroglia;Neurons;novel;Nuclear;Nuclear RNA;oligodendrocyte lineage;Organoids;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Pericytes;Pharmaceutical Preparations;Phase;Phenocopy;Phenotype;Predictive Value;presenilin-1;Production;Property;Prosencephalon;prospective;Proteomics;Protocols documentation;release factor;Reporting;Reproducibility;Research;research clinical testing;response;Safety;Sampling;self assembly;Shapes;side effect;Smooth Muscle Myocytes;stem cell model;stressor;Structure;success;symposium;tau Proteins;tau-1;Testing;tissue culture;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Translations;Validation;Vascular Endothelial Cell

PROJECT_TITLE: Human iPSC model of Cerebro-Vascular Interactions in ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (19)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE More than 76 million Americans use opioid drugs as analgesics for the treatment of long-term pain, and more than 2 million Americans now have opioid use disorder. This research program will identify and evaluate molecular mechanisms intimately linked to treatment of chronic pain, addiction, and withdrawal. Thus, this project has long-term potential to contribute significantly to managing two major problems in medicine.

PI_NAMEs: GRILL, BROCK  (contact);MARTEMYANOV, KIRILL A.

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acute;addiction;Address;Adenosine;Affect;American;Analgesics;Animals;Behavior;Behavior Control;Behavioral;behavioral response;Biochemical;Biological;Biological Assay;Biology;Caenorhabditis elegans;Candidate Disease Gene;Categories;Cells;chronic pain management;Corpus striatum structure;Coupled;Dependence;desensitization;Engineering;Exhibits;Family;Fentanyl;forward genetics;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;genetic regulatory protein;Genetic Screening;Genetic study;Goals;Golgi Apparatus;golgin;GPSM1 gene;GTP-Binding Proteins;Homologous Gene;in vivo;insight;interdisciplinary approach;Link;Mammalian Cell;Mammals;Mediating;Medicine;Modeling;Molecular;Molecular Genetics;Molecular Probes;Monitor;Morphine;mutant;Nature;Nervous System;novel;Opioid;Opioid Analgesics;Opioid Receptor;opioid therapy;opioid use;opioid use disorder;Organism;Orphan;Pain;Pain management;Peripheral;Pharmaceutical Preparations;Phenotype;Positioning Attribute;prevent;Process;Productivity;programs;Proteins;Publishing;receptor;receptor function;Receptor Signaling;Regulation;Research;response;Rewards;Rodent;Role;Saccharomyces cerevisiae;sensor;Shapes;side effect;Signal Transduction;success;System;Time;trafficking;trans-Golgi Network;Transgenic Organisms;Validation;Withdrawal;Work;Yeast Model System

PROJECT_TITLE: Molecular genetic mechanisms of opioid receptor signaling

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: This research addresses a critical public health challenge by developing a high-accuracy AI tool for early glaucoma detection. By leveraging advanced AI applied to widely available fundus photography, the project aims to improve access to early and accurate diagnosis in settings where traditional diagnostic resources may be limited. This approach has the potential to prevent avoidable vision loss and significantly reduce the burden of glaucoma.

PI_NAMEs: MEDEIROS, FELIPE  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Address;Affect;Agreement;Area;Artificial Intelligence;Black race;Blindness;Caring;Clinic;Communities;Community Services;convolutional neural network;cost;cost effective;County;Data Science;Data Set;Databases;deep learning;deep learning algorithm;deep learning model;deep neural network;Detection;Development;Diagnosis;Diagnostic Services;diagnostic tool;Disease;Disparity;Early Diagnosis;Ensure;Equitable healthcare;Equity;ethnic disparity;Ethnic Origin;Evaluation;Exhibits;Eye;flexibility;Florida;Fundus;Fundus photography;generative artificial intelligence;Glaucoma;health care disparity;health care settings;Health Fairs;health goals;high risk;Hispanic;Human;Imaging technology;improved;Individual;innovation;Label;Latino;Lead;learning network;Los Angeles;Manuals;Measurement;Measures;Modeling;Names;Nature;neural;Optical Coherence Tomography;Outcome;Patients;Performance;Population;population based;Population Heterogeneity;Population Study;Prevalence;prevent;programs;Public Health;Publications;racial disparity;racial population;Registries;Reproducibility;Research;retinal nerve fiber layer;Risk;screening;Screening procedure;screening program;Sensitivity and Specificity;Series;service programs;socioeconomics;Strategic Planning;Surveys;teleophthalmology;Testing;Thick;tool;Training;underserved community;Underserved Population;United States;Universities;urban area;Validation;Vision;Visit

PROJECT_TITLE: Validation and Implementation of an Artificial Intelligence Machine-to-Machine (M2M) Model for Glaucoma Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ORG_DEPT: UROLOGY

PHR: Project Narrative Prostate cancer (PCa) is a leading cause of cancer-related death in American men, with lethality due largely to castration-resistant prostate cancer (CRPC). This study will develop degraders (PROTACs) that fully target/degrade EZH2, a major driver of late-stage metastatic PCa and evaluate their therapeutic potential in PCa models. In addition, we will exploit PROTACs as tool compounds to study the EZH2 biology in various stages of PCa.

PI_NAMEs: SCHILTZ, GARY E;YU, JINDAN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;American;androgen independent prostate cancer;Androgen Receptor;AR gene;Binding;Biology;c-myc Genes;Cancer Etiology;Cell Aging;Cell Proliferation;Cessation of life;Chemicals;Complex;Data;Development;Diagnosis;Disease;drug discovery;Drug Kinetics;Drug Targeting;EP300 gene;Epigenetic Process;epigenetic silencing;EZH2 gene;Follicular Lymphoma;Future;Gene Activation;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;histone methylation;histone methyltransferase;improved;In Vitro;in vivo;in vivo Model;inhibitor;Invaded;knock-down;Lead;lead optimization;Ligand Binding;luminescence;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;Metastatic Prostate Cancer;Methylation;Modeling;Modification;Mus;novel;novel therapeutic intervention;Oncogenes;Operative Surgical Procedures;Pathway interactions;Pharmaceutical Chemistry;Pharmacologic Substance;Polycomb;Property;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Protac;Proteins;Radiation;Refractory;Relapse;Reporting;Resistance;Role;Series;SET Domain;small molecule;small molecule inhibitor;STAT3 gene;stemness;Structure of base of prostate;Survival Rate;Targeted Research;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Toxic effect;Translational Research;tumor;tumor growth;tumor xenograft;tumorigenesis;ubiquitin-protein ligase;Western Blotting

PROJECT_TITLE: Development of Protein Degraders Targeting EZH2 Non-enzymatic Functions in Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE A growing number of Americans over the age of 65 live with dementia, brought on by a set of devastating neurodegenerative diseases with overlapping pathologies and symptoms, including Alzheimer’s disease (AD), frontotemporal lobar degeneration, and other AD related dementias (AD/ADRD). While the ultimate molecular mechanisms driving neurodegeneration in AD/ADRD are poorly understood, our previous work and preliminary results demonstrate disruptions to nuclear protein quality control are characteristic of AD/ADRD and that the activity of nuclear ubiquitin ligase complexes control pathological tau, TDP-43, and other protein aggregation in disease. The completion of the proposed work will provide further insight into biological mechanisms underlying the role of BRD transcription factor degradation (F99) and, more broadly, the role of disruptions to nuclear protein homeostasis (K00) in driving neurodegeneration in AD/ADRD.

PI_NAMEs: ECK, RANDALL  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Adaptor Signaling Protein;Age;Age of Onset;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;American;Automobile Driving;Autopsy;Behavioral;Binding Proteins;Biological;Brain;BRD2 gene;Bromodomain;Caenorhabditis elegans;Calcium Signaling;Characteristics;cohort;Complex;cullin-3;Data;Defect;Dementia;Disease;DNA Repair;early onset;Environment;Family;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;Genetic Transcription;Hippocampus;Homeostasis;Homologous Protein;Human;human disease;human old age (65+);Huntington Disease;hyperphosphorylated tau;Individual;Induced pluripotent stem cell derived neurons;Inherited;insight;life span;loss of function;Mentors;Microtubules;Modeling;Molecular;multicatalytic endopeptidase complex;Mus;mutant;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;neurotoxic;neurotoxicity;novel;Nuclear;Nuclear Envelope;Nuclear Pore Complex;Nuclear Protein;Nuclear Proteins;nucleocytoplasmic transport;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Phase;polyglutamine;Prevalence;programs;protein aggregation;protein degradation;protein TDP-43;Proteins;proteostasis;Publishing;Quality Control;Research;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;sex;Stress;Symptoms;System;tau aggregation;tau Proteins;Tauopathies;TDP-43 aggregation;Toxic effect;transcription factor;transcription factor PML;transcriptome sequencing;Transgenic Animals;Transgenic Organisms;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Disruptions to nuclear proteostasis machinery as drivers of neurodegeneration in dementia.


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE (PI: YU) Proposed study aims to improve the efficacy of existing rheumatoid arthritis antibody drugs by attaching a peptide that specifically binds to degraded collagens abundant in inflamed joint tissues (bones and cartilage). Antibody drug that can be localized to diseased tissue will exhibit high efficacy and low systemic side effects.

PI_NAMEs: YU, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affinity;Animals;Anti-Tumor Necrosis Factor Therapy;Antibodies;antibody engineering;Antibody Therapy;Arthritis;Autoimmune Diseases;bevacizumab;Binding;Biological;Biology;bone;Bone Diseases;Cartilage;Cartilage Diseases;Cells;Chemistry;Chronic Disease;Collagen;comparative efficacy;cytokine;Cytometry;Data;Degenerative Disorder;design;Development;Dimensions;dimer;Disease;dosage;Dose;Educational process of instructing;efficacy study;Exhibits;experience;Extracellular Matrix;follow-up;Goals;Histology;Immune;immune activation;immune checkpoint;immune modulating agents;Immunoglobulin G;Immunologic Memory;Immunosuppression;improved;In Vitro;in vivo;in vivo imaging;Infection;Inflammatory;infliximab;joint inflammation;Joints;Label;Link;Malignant Neoplasms;Methods;Modeling;mouse model;Mus;Nature;next generation;Osteoporosis;Paper;Pathologic;Patients;Peptide Hydrolases;peptide structure;Peptides;Periodicals;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;Physiological;Plasma;Production;Property;Publishing;Radiochemistry;radiotracer;Reaction;Research;Research Personnel;Rheumatoid Arthritis;Serum;side effect;Site;skeletal tissue;Source;Specialist;stoichiometry;Structure;success;Symptoms;Synovitis;Technology;tertiary lymphoid organ;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;Tissues;TNF gene;Toxic effect;Treatment Protocols;triple helix;Work

PROJECT_TITLE: Localization of Antibody Drugs to Arthritic Joints via Collagen Hybridization

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Research shows that group singing can improve health and promote happiness. We will develop, refine, and investigate the feasibility and acceptability of an online group singing intervention for adults age 60+ with brain disorders of aging (i.e., mild cognitive impairment) according to the NIH music-based intervention (MBI) Toolkit principles. Results from this study will support a larger, subsequent effectiveness trial that will rigorously evaluate our online MBI following principles of the NIH MBI Toolkit.

PI_NAMEs: CHAO, LINDA L (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Age;aged;Aging;aging related disease;Alzheimer's disease related dementia;arm;attentional control;Behavior;behavior change;behavior influence;Brain Diseases;brain health;Brain region;Buffers;Cognition;Cognitive;cognitive control;cognitive function;cognitive reserve;Communities;Complex;Consensus;cost;cost effective;Data;Dementia;dementia risk;Development;Disease;Disease Progression;effectiveness trial;Elderly;Emotional;experience;feasibility testing;feasibility trial;Guidelines;Happiness;Health;Health behavior;Health Benefit;healthy lifestyle;Home;Homeostasis;Hormones;human centered design;Hydrocortisone;Impaired cognition;improved;Individual;Informal Social Control;innovation;Integrative Medicine;Intervention;Language;late life;Learning;Medicine;Mental Depression;Mental Health;mild cognitive impairment;multidisciplinary;Music;Music Therapy;neuroimaging;Neurologic;Neuronal Plasticity;Neuropeptides;Neurosciences;older adult;Oxytocin;Participant;Patients;Personal Satisfaction;Persons;pharmacologic;Phase;pilot trial;Play;post intervention;pre-clinical;Process;Psyche structure;Quality of life;Randomized;randomized effectiveness trial;recruit;Research;Research Personnel;Research Proposals;Risk;Science;side effect;social;social attachment;Social isolation;Social Processes;social relationships;Stress;stress reactivity;Testing;Time;United States;United States National Institutes of Health;virtual;web-based intervention

PROJECT_TITLE: Feasibility of Tele-Singing at Home for Older Adults with Mild Cognitive Decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (09)]


ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE  Our proposal utilizes mouse genetic, live-cell imaging, flow cytometry, biochemistry, and molecular biology approaches to identify 1) how Hpf1 and Parp2 collaborate to regulate Parp1 dynamics at DNA damage sites; 2) how HPF1 regulates the substrate and PAR chain structural specificity; 3) how HPF1 prevents PARP1 trapping induced hematopoietic failure promoting PARP1 release. The goal is to understand the complexity of radiation and replication-induced PARylatio and develop strategies (e.g., targeting Hpf1 compound catalytic site) to mitigate bone marrow toxicities in radiation and PARPi treatment.

PI_NAMEs: ZHA, SHAN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Ablation;Acute;Acute Myelocytic Leukemia;Address;Adenosine Diphosphate Ribose;Affect;Aftercare;Alkylating Agents;Amino Acids;AML/MDS;Anemia;Aspartate;Binding;Binding Proteins;Biochemistry;Biological;Blood specimen;Bone Marrow;BRCA1 gene;BRCT Domain;Cancer Patient;cancer radiation therapy;cancer therapy;Catalytic Domain;Cells;Charge;Cisplatin;Clinical;Collaborations;Combined Modality Therapy;Complex;Complication;Data;Defect;Development;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair Gene;DNA replication fork;Dose Limiting;Embryo;Erythroblasts;Erythropoiesis;Failure;Fatigue;Flow Cytometry;genotoxicity;Glutamine;Goals;Hematology;Hematopoiesis;Hematopoietic;Histones;inhibitor;irradiation;Knockout Mice;Length;Link;live cell imaging;Maintenance Therapy;Malignant Neoplasms;Measurable;Molecular Biology;mouse genetics;Mus;Mutant Strains Mice;nucleoside analog;Okazaki fragments;Outcome;Patients;Phosphorylation;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;prevent;Proteins;Radiation;Radiation therapy;Reactive Oxygen Species;Reader;recruit;repaired;replication therapy;response;Risk Factors;Role;Serine;side effect;Site;Specificity;Structure;targeted cancer therapy;Testing;therapy development;Toxic effect

PROJECT_TITLE: The role of HPF1 in radiation and genotoxic cancer therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Positive-strand RNA virus-related diseases are a significant global health burden and viruses from this group represent a high risk for new and emerging human pathogens. Our research seeks to identify and define common host pathways utilized by positive-strand RNA viruses to better understand mechanisms of infection and uncover potential therapeutic targets.

PI_NAMEs: NEUFELDT, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3-Dimensional;Address;Anti-viral Agents;Biochemical;Biogenesis;Cell Physiology;Cells;Cellular biology;Cellular Membrane;climate change;cofactor;Communities;Data;Dengue Virus;Disease;Disease Outbreaks;Distant;Electron Microscopy;emerging human pathogen;Environment;Evaluation;experimental study;Flavivirus;Flavivirus Infections;genetic manipulation;global health;Goals;high risk;Human;human disease;Imaging Techniques;Infection;innovation;Insecta;insight;Integration Host Factors;light microscopy;Measures;Mediating;Mediator;Membrane;Membrane Proteins;Methods;Microscopy;Molecular;Molecular Biology;Morphology;Movement;Mutagenesis;Mutation;N-terminal;novel;Organelles;pathogen;Pathway interactions;Plasmids;Population;Population Distributions;Positioning Attribute;Process;Production;programs;protein function;protein transport;Proteins;reconstitution;recruit;Replicon;Research;reverse genetics;Risk;RNA Virus Infections;RNA Viruses;Role;Shapes;South America;Structure;System;Techniques;Testing;Therapeutic;therapeutic target;tool;Transfection;ultra high resolution;Vaccines;Viral;Viral Genome;Viral Proteins;viral RNA;virology;Virus;Virus Diseases;virus genetics;virus infection mechanism;Virus Replication;Visualization;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Host factor contribution to positive-strand RNA virus induced membrane reorganization

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Developing an animal model that recapitulates heterogeneous outcomes of hepatitis C virus (HCV) infection and pathogenesis has been a long-sought goal of biomedical research. This project will develop and characterize a new, widely accessible, and informative mouse model to study HCV-like spontaneous delayed clearance and chronic infection is, therefore, highly innovative and will significantly expand this field of research.

PI_NAMEs: KAPOOR, AMIT  (contact)

PROJECT_TERMS: Affect;Amino Acids;Animal Model;Biological;Biomedical Research;CD8-Positive T-Lymphocytes;Cell Proliferation;Cells;Chronic;Chronic Hepatitis C;chronic infection;co-infection;Comparative Biology;Data;experimental study;Flavivirus;gain of function;genetic resource;Genome;Genomic Segment;Goals;Haplotypes;HCV Animal Models;Hepatitis C;Hepatitis C virus;Hepatitis C-Like Viruses;Hepatocyte;Immune;Immune Cell Suppression;Immune Evasion;Immunity;Immunocompetent;Immunologics;Immunosuppression;Individual;Infection;innate immune sensing;innovation;insight;Interferons;IRF3 gene;Kinetics;Knowledge;Leucocytic infiltrate;Liver;Maps;Molecular;mouse model;Mus;Mutagenesis;Mutate;Mutation;Natural Selections;Nature;Outcome;overexpression;Parents;Pattern;Peptide Hydrolases;Positioning Attribute;Predisposition;Property;Proteins;Rattus;Rattus norvegicus;Research;RNA Viruses;Rodent;Serial Passage;Signal Transduction;Site-Directed Mutagenesis;Solid;Specificity;T-Lymphocyte;Testing;TLR2 gene;transcriptome;Variant;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;Viremia;Virion;Virus;Virus Diseases

PROJECT_TITLE: Viral Determinants of Chronic Hepacivirus Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-Q (90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Comparative Effectiveness Research;Dementia;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Older adults frequently cite maintenance of cognitive function and prevention of dementia as their top health priority. This is highly relevant to cardiovascular treatment decisions as the modifiable risk factors for cognitive decline and cardiovascular disease overlap and early data suggest potentially differential treatment effects of cardiovascular therapies on cognitive outcomes. We propose to evaluate the effect of two of the most commonly prescribed cardiovascular therapies (Beta-blockers & Calcium Channel Blockers) on cognitive trajectory and risk for Alzheimer’s Disease and Related Dementias among older adults by leveraging existing longitudinal data from SPRINT MIND and prospective randomized trial data from the PCORI-sponsored LIVEBETTER pragmatic trial.

PI_NAMEs: NANNA, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Adult;Advisory Committees;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;apolipoprotein E-4;Atherosclerosis;Award;Awareness;Biometry;Blood Pressure;Blood Vessels;Brain;brain health;Calcium Channel Blockers;Capsicum;Cardiac health;Cardiology;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;career development;Caring;Cholesterol;Clinical;Clinical effectiveness;Clinical Research;Cognition;Cognitive;cognitive function;Cognitive Therapy;comparative effectiveness;compare effectiveness;Data;Dementia;dementia risk;Development Plans;Diabetes Mellitus;Drug Prescriptions;education resources;Effectiveness;Environment;experience;follow-up;Funding;Future;Geriatrics;Gills;Glean;Goals;Grant;Guidelines;hazard;Health Priorities;Health Sciences;healthy aging;Heart;heart function;Heterogeneity;holistic approach;Hyperlipidemia;Hypertension;hypertension control;Impaired cognition;Incidence;Infrastructure;International;Intervention;Knowledge;Leadership;Link;Long-Term Effects;longitudinal analysis;Maintenance;Measures;medical schools;Mental Depression;Mentors;Mentorship;Methodology;mild cognitive impairment;modifiable risk;mortality;multiple chronic conditions;Myocardial Ischemia;Obesity;older adult;Older Population;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physical Function;physical inactivity;Positioning Attribute;pragmatic trial;prevent;Prevention;Probability;programs;prospective;Quality of life;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;Risk;Risk Factors;Sample Size;Science;skills;Smoking;social health determinants;success;Testing;therapeutic effectiveness;therapeutic target;Time;Training;treatment effect;trial comparing;trial design;United States

PROJECT_TITLE: Estimating the treatment effect of cardiovascular medications to modify the risk for future cognitive decline in older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH STATEMENT Hypertension is a leading risk factor for global morbidity and mortality due to its effects on the heart, blood vessels and kidney leading to heart attacks, heart failure, stroke, and chronic kidney disease. These effects of hypertension seem to be mediated by an imbalance of pro- and anti-inflammatory cells of the immune system, but the precise mechanisms are unclear. By investigating what causes this imbalance and reversing it, this project can potentially lead to novel diagnostic and therapeutic targets for hypertension and related cardiometabolic diseases.

PI_NAMEs: MADHUR, MEENAKSHI SWAMINATHAN (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acetates;Address;Adoptive Transfer;Adult;Affect;Angiotensin II;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Antigens;Autoimmune Diseases;Biological Availability;Blood Pressure;blood pressure reduction;Blood Vessels;Cardiometabolic Disease;cardiovascular risk factor;Cardiovascular system;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Kidney Failure;cytokine;Data;Deoxycorticosterone;Development;Endothelial Cells;endothelial dysfunction;Equilibrium;Etiology;Event;Fibrosis;Functional disorder;Heart;Heart failure;Helper-Inducer T-Lymphocyte;Human;humanized mouse;Hypertension;hypertension treatment;hypertensive;Immune;immune activation;immune function;Immune system;immunodeficiency;Immunodeficient Mouse;Immunology procedure;immunomodulatory therapies;immunoregulation;Immunosuppression;in vivo;Individual;Infection;infection risk;Inflammation;Inflammatory;inhibitor;Injury;interleukin-21;Interleukins;IRF4 gene;Kidney;Knockout Mice;Leukocytes;Lipopolysaccharides;Malignant Neoplasms;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;new therapeutic target;normotensive;novel;novel diagnostics;novel marker;Oral;Organ;Pathway interactions;Patient Care;Patients;peripheral blood;Persons;Phase II/III Clinical Trial;Phenotype;Phosphorylation;potential biomarker;Predisposition;prevent;Prevention Protocols;Production;programs;Proliferating;Protein Kinase;Public Health;Reagent;Regulatory T-Lymphocyte;response;rho;Risk Factors;Rodent Model;Role;Safety;salt sensitive hypertension;Signal Transduction;Sodium;STAT3 gene;Stat5 protein;Stimulus;Stroke;systemic inflammatory response;T cell differentiation;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Therapeutic immunosuppression;therapeutic target;tissue injury;Translating;translational study;Treatment Protocols;vascular inflammation;Work

PROJECT_TITLE: Immune Modulation in Hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Neural connectivity is altered in many, if not most, neurodevelopmental disorders, such as schizophrenia and autism. A mechanistic understanding of how the neural circuitry is formed is crucial in revealing how neurodevelopmental disorders emerge and discovering new approaches to treat these debilitating diseases. The work proposed here will uncover fundamental molecular mechanisms that regulate neural circuit development, and although our work is conducted in Drosophila, these processes and mechanisms are conserved.

PI_NAMEs: CARRILLO, ROBERT ARNULFO;OZKAN, ENGIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affinity;Animals;autism spectrum disorder;Axon;axon growth;Behavior;Binding;Biochemical;Biological Assay;Biophysics;Brain;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;Cell Culture Techniques;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Code;Collection;combinatorial;Complement;Complex;Data;Development;Dimerization;Disease;Drosophila genus;Drosophila melanogaster;Embryo;Engineering;experimental study;Family;Family member;fly;follow-up;Genes;Genetic;Growth;Human;Immunoglobulins;In Vitro;in vivo;insight;Knowledge;Larva;Lead;Learning;Ligands;Location;Measures;Mediating;Modeling;Molecular;molecular recognition;Motor;Muscle;Mutation;Nematoda;nerve supply;Nervous System;neural;neural circuit;Neurodevelopmental Disorder;neuromuscular;neuromuscular system;neuron loss;neuronal circuitry;neuronal survival;Neurons;neurotransmission;novel;novel strategies;Optic Lobe;Orthologous Gene;overexpression;Pathway interactions;Pattern;Phenotype;Physiology;Process;Protein Family;Protein Secretion;Proteins;receptor;reconstitution;Regulation;Role;Schizophrenia;Sensory Receptors;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Specific qualifier value;Specificity;Stereotyping;Structure;Surface;Surface Plasmon Resonance;Synapses;synaptogenesis;Testing;Work

PROJECT_TITLE: Mechanistic studies of molecular recognition and signaling of neuronal wiring receptors

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BROOKLYN

ORG_DEPT: PSYCHIATRY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Project Narrative African diaspora communities and other underrepresented populations have been poorly represented in large scale genetic and epidemiological research on serious mental illnesses (SMI), and yet these populations have the largest disparities in health care and outcomes. This study builds on a prior study of untreated psychoses in Nigeria and Trinidad, newly adding a cohort of patients receiving inpatient psychiatric care, and featuring a philanthropically- supported whole-genome sequencing aim. Comparative clinical and genomic analyses with data for US veterans and civilians with linked electronic health records, and with other diverse populations in Africa and globally will inform how biological and non-biological factors influence clinical presentation and health outcomes among individuals with psychotic illness.

PI_NAMEs: BIGDELI, TIM BERNARD (contact);GUREJE, OYEWUSI ;HUTCHINSON, GERARD

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;access disparities;Africa;African;African ancestry;Area;Behavior;Belief;Benchmarking;Biological;Caribbean region;Clinical;Clinical Data;clinical epidemiology;Code;cognitive function;cohort;Cohort Studies;Collaborations;Collection;Communities;comorbidity;comparative;cooperative study;Copy Number Polymorphism;Data;design;Diagnosis;disability-adjusted life years;Electronic Health Record;epidemiology study;Equity;Feasibility Studies;follow up assessment;Future;Generations;Genes;genetic epidemiology;Genetic Research;genome sequencing;genomic data;genomic variation;Genomics;Health;health care availability;health care disparity;health disparity;Health Sciences;health seeking behavior;Hospitalization;Individual;Infection;inpatient psychiatric treatment;insight;International;Link;Locales;low and middle-income countries;Medicine;Mental disorders;Modernization;mortality;National Institute of Mental Health;Nigeria;Nigerian;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Participant;patient population;Patients;Persons;Pharmacological Treatment;Phenotype;physical conditioning;poor health outcome;Population;Population Analysis;Population Heterogeneity;Prevalence;programs;Proteins;Psychoses;Psychotic Disorders;rare variant;recruit;Research;Research Infrastructure;Resources;Schizophrenia;severe mental illness;Severities;Site;social culture;social epidemiology;social health determinants;Solid;Strategic Planning;Structure;substance use;Symptoms;Techniques;Tobago;Trauma;trauma exposure;treatment response;Trinidad;Underrepresented Populations;United States;Universities;Urbanicity;Variant;Veterans;West Indies;whole genome;Work

PROJECT_TITLE: Psychosis in Ancestrally Diverse Settings (PADS)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Patient Safety

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Surgery is often deferred for older adults with inflammatory bowel disease (IBD) given the higher risk of adverse surgical outcomes as compared to younger adults with IBD. These delays, however, paradoxically increase the risk of an adverse postoperative event when surgery is required. A better understanding of which older adults with IBD are likely to need disease-related surgery, which preoperative factors contribute to the risk of adverse surgical outcomes, and which barriers exist for timely surgery can shift this trajectory and help inform evidence-based interventions.

PI_NAMEs: FAYE, ADAM SCOTTE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adult;adverse event risk;Age;Age Years;Aging;aging related;American College of Surgeons;Award;Biological Response Modifier Therapy;career;career development;Caring;Chronology;Clinical;Cognition;cognitive function;cohort;Colorectal;comorbidity;Complication;Coupled;Crohn's disease;Death Rate;demographics;design;Development;Development Plans;Discrimination;Disease;disease phenotype;Educational workshop;Elderly;Emergency Situation;Environment;Event;evidence base;Evidence based intervention;Excision;experimental study;frailty;Funding;Future;Gastroenterologist;Geriatric Assessment;Goals;Grant;Habilitation;Healthcare;high risk;Hospitals;human old age (65+);illness length;Impaired cognition;improved outcome;Individual;Inflammation;Inflammatory Bowel Diseases;Intervention;Interview;Intestines;Knowledge;Lead;Leadership;Learning;Location;longitudinal analysis;Malnutrition;Measures;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;nutrition;older adult;older patient;Older Population;Online Systems;Operative Surgical Procedures;Outcome;patient population;Patient Preferences;patient subsets;Patients;Persons;Pharmaceutical Preparations;Physical Function;Physiological;Population;population based;Postoperative Period;predictive modeling;Preoperative Care;Prospective cohort;provider factors;Race;Reporting;Research;Research Personnel;Risk;risk mitigation;risk prediction;risk prediction model;risk stratification;sarcopenia;Scientist;Severity of illness;sex;Smoking Status;Specific qualifier value;Statistical Models;statistics;Surgeon;surgery outcome;Surgical complication;surgical risk;Surveys;symposium;Time;Tobacco use;tool;Training;Ulcerative Colitis;Work;working group;young adult

PROJECT_TITLE: Optimal Preoperative Care for Older Adults with Inflammatory Bowel Disease (K76) - Resubmission - 1