ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE – OVERALL This Program Project Grant (PPG) was developed to improve precision cancer diagnostics, develop new methods to prevent of stomach cancer and address important questions surrounding Helicobacter pylori’s (Hp) effect on cancer development. The research team will develop new ways of intercepting stomach cancer in its earliest stage such that it can be eliminated from patients.

PI_NAMEs: HWANG, JOO HA;JI, HANLEE P (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;Administrative Coordination;Affect;American;antimicrobial;Attenuated;attenuation;Bacteria;Basic Science;Biological Markers;Biological Specimen Banks;Biology;biomarker discovery;biomarker identification;Biometry;Cancer Biology;cancer diagnosis;Cancer Diagnostics;Cancer Etiology;cancer prevention;cancer risk;carcinogenesis;Chile;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;Clinical Trials;clinically relevant;cohort;Communicable Diseases;Communication;Data;Data Analyses;data management;Detection;Development;Diagnosis;Early Diagnosis;Ensure;epidemiology study;Epithelial Cells;Epithelium;Experimental Models;Foundations;Gastric Adenocarcinoma;gastric cancer prevention;gastric carcinogenesis;gastric intestinal metaplasia;Gastroenterology;gastrointestinal;genetic analysis;Genome;genomic data;Genomics;Goals;Health Expenditures;Helicobacter Infections;Helicobacter pylori;high risk;Image;improved;Individual;Infection;Inflammatory;insight;Intercept;interdisciplinary approach;Interdisciplinary Study;Lesion;Longterm Follow-up;Malignant Neoplasms;malignant stomach neoplasm;medical specialties;Methods;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;neoplasm registry;novel;novel strategies;Occupational activity of managing finances;Oncology;Outcome;patient subsets;Patients;Persons;Precancerous Conditions;precision cancer prevention;precision medicine;premalignant;Preneoplastic Change;Prevention;Prevention strategy;Program Research Project Grants;programs;Public Health;Research;Resources;Risk;Risk Factors;risk stratification;Sampling;Screening for cancer;Screening for Gastric Cancer;single cell sequencing;stem cell niche;Stomach;synergism;Translational Research;tumor progression;United States;Universities

PROJECT_TITLE: Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: CA

PHR: NARRATIVE – PROJECT 1 Gastric cancer is a leading cause of cancer morbidity and mortality worldwide and is associated with poor clinical outcomes and limited therapeutic options. Early detection of precancerous lesions, particularly gastric intestinal metaplasia, has the potential to identify patients at highest risk for neoplastic progression, enable novel prevention strategies, and ultimately enhance health outcomes and reduce mortality for individuals with gastric cancer. Project 1 aims to characterize the precise molecular and cellular landscape of high-risk gastric intestinal metaplasia, and leverage this information to improve gastric cancer detection, prevention, and treatment.

PI_NAMEs: JI, HANLEE P (contact)

PROJECT_TERMS: 20q;Age;Anatomy;Atrophic;Bacteria;Biology;Cancer Detection;Cancer Etiology;candidate marker;Categories;Cells;Cellular biology;Cessation of life;Chromosome abnormality;Chromosome Arm;Chromosome Mapping;Chronic;Classification;Clinical;clinical biomarkers;clinical risk;cohort;Correa cascade;detection method;Diagnosis;DNA Sequence Alteration;Dysplasia;Early Diagnosis;Epigenetic Process;Epithelial Cells;Epithelium;Event;gastric intestinal metaplasia;gastric organoids;Gastric Tissue;Gastritis;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genomic aberrations;Genomics;Goals;Health;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;high risk;high risk population;Histologic;Human;Immunohistochemistry;improved;Individual;Infection;Inflammation;insight;Intestinal Metaplasia;Intestines;Lesion;Lesion by Stage;Link;Location;malignant stomach neoplasm;Methods;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;multi-ethnic;multiple omics;novel;Outcome;Patients;Pattern;Population;Precancerous Conditions;premalignant;Prevention;Prevention strategy;Process;progression risk;Property;Proteins;Risk;Risk Assessment;Risk Factors;risk stratification;Sampling;sex;single cell genomics;Somatic Mutation;Specimen;Staging;Staging System;stem cells;Stomach;Stomach Carcinoma;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;Translating;tumor progression;United States;Work

PROJECT_TITLE: Project 1 - Molecular and Cellular Determinants of High Risk Gastric Precancerous Lesions


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Bioreagents and Resource Core supports the goals of the P01 by provision of high quality biospecimens of multiple types to the P01 investigators. The Core also provides multiple skills and services – such as pathology diagnostics, microdissection, immunohistochemistry, tissue microarrays and quality control of spatial transcriptomics and single cell sequencing and engages in ongoing consultation via regularly scheduled meetings to help ensure success of each P01 project. The Core faculty have extensive experience in esophageal translational research and have been integral to the scientific discoveries leading to this submission.

PI_NAMEs: WILLIS, JOSEPH EDWARD (contact)

PROJECT_TERMS: Address;Animals;Archives;Barrett Esophagus;Barrett's carcinogenesis;Basic Science;biobank;Biological Assay;Blood;blood fractionation;Blood specimen;Body Fluids;cancer prevention;carcinogenesis;Cell Line;central database;Clinical;Clinical Research;Collaborations;Collection;Color;Complex;Comprehensive Cancer Center;Confidentiality of Patient Information;Consultations;Custom;design;Development;Diagnostic;Dissection;DNA;DNA Library;Dysplasia;Ensure;EPHB2 gene;Epithelium;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophageal injury;Esophageal Neoplasms;Esophageal Tissue;Esophagectomy;Esophagus;experience;Faculty;Family;Family suidae;follow-up;Formalin;Freezing;Fresh Tissue;Funding;gastrointestinal;Genomics;Germ Lines;Gland;Goals;High grade dysplasia;Histology;Human;human tissue;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;Inherited;injury and repair;insight;Institutional Review Boards;Investigation;Knock-in;Knockout Mice;laser capture microdissection;Link;Medical Records;meetings;Metaplasia;Microdissection;Modeling;Molecular;Morphology;mouse model;Mus;novel;novel strategies;Outcome;Paraffin Embedding;Pathologist;Pathology;Pathway interactions;Patients;Play;Predisposing Factor;Predisposition;Preparation;Procedures;Program Research Project Grants;programs;quality assurance;Quality Control;Reagent;Records;repository;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;RNA;Role;Sampling;Schedule;screening;Services;Signal Transduction;single cell sequencing;Site;skills;Specimen;Submucosa;success;Susceptibility Gene;Technology;technology/technique;Test Result;tissue archive;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Procurements;tissue resource;Tissue Sample;Tissues;transcriptomics;Translational Research;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: Bioreagents & Resources Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed CURE for Cancer program will develop and implement a multifaceted, culturally relevant cancer- focused research experience for American Indian and Hispanic high school and undergraduate students. By cultivating student interests in college to graduate and professional schools, boosting their self-efficacy in science, and helping them attain skills needed to apply and ultimately succeed in higher education programs, we expect CURE for Cancer trainees will productively contribute to tackling the significant education and health needs of underserved communities locally and nationally. Moreover, the emphasis on American Indian and Hispanic students from under-resourced communities will address national priorities for their recruitment and retention in STEM-H careers, especially biomedical science and cancer-related health careers that address the health disparities experienced by these populations.

PI_NAMEs: GILLETTE, JENNIFER  (contact);GUEST, DOLORES

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Advisory Committees;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Awareness;career;Career Choice;career development;Censuses;Chronic Disease;Classification;Clinical;cohort;college;Communities;community engagement;Comprehensive Cancer Center;Coupled;Coupling;Creativeness;cultural values;Degree program;design;Economics;Education;Educational Curriculum;Educational workshop;Enrollment;Ensure;ethnic diversity;ethnic minority population;Evaluation;experience;Future;Goals;Health;health disparity;Health education;Health Occupations;High Prevalence;high school;high school program;higher education;Hispanic;Hispanic Americans;hispanic community;Hispanic Populations;improved;Incidence;Inflammation;innovation;Interdisciplinary Study;interest;Internships;junior high school;Knowledge;Lead;Learning;Malignant Neoplasms;Mentors;Middle School Student;Minority-Serving Institution;Morbidity - disease rate;mortality;Native American community;New Mexico;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;outreach;Pathway interactions;pedagogy;peer;peer coaching;peer learning;peer networks;Personal Satisfaction;Persons;Population;Poverty;Productivity;Professional Competence;programs;Race;racial diversity;recruit;Research;Research Activity;Research Training;Resources;response;role model;Rural;rural dwellers;Schools;Science;science education;Self Efficacy;skills;socioeconomics;student participation;Student Persistence;Students;success;summer research;symposium;synergism;Talents;Training;Training Programs;Translating;tribal community;Tribes;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;underserved community;Universities;Work;Youth

PROJECT_TITLE: University of New Mexico's CURE for Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods to ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project.

PI_NAMEs: LAFRAMBOISE, THOMAS LOUIS (contact)

PROJECT_TERMS: analytical method;Barrett Esophagus;Barrett's carcinogenesis;Cancer Center;cancer epidemiology;cancer prevention;carcinogenesis;Cells;Clinical;Collaborations;Communication;Complex;Comprehensive Cancer Center;Computer Analysis;computer infrastructure;Data;Data Analyses;data management;Data Set;data sharing;Database Management Systems;Databases;design;Development;Diagnosis;Disease;Dysplasia;Early Diagnosis;Ensure;Environmental Risk Factor;Esophageal injury;Etiology;Experimental Designs;experimental study;Faculty;Formulation;Foundations;gastrointestinal;Gene Modified;Genes;genetic epidemiology;genome-wide;Goals;Grant;Human Resources;Information Dissemination;Infrastructure;Inherited;Injury;injury and repair;innovation;Institution;Investments;large scale data;Leadership;Malignant neoplasm of esophagus;Manuscripts;medical schools;meetings;Metaplasia;Methods;Molecular;Molecular Profiling;Multiomic Data;multiple omics;novel;Pathway interactions;Physiology;Positioning Attribute;Pre-Clinical Model;Predisposition;Prevention;Program Research Project Grants;programs;repaired;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Secure;skills;Specialized Program of Research Excellence;Systems Biology;Testing;Tissue Model;Tissues;Training Programs;Universities;wound healing;Writing

PROJECT_TITLE: Integrative Systems Biology Core


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: RAFT PHARMACEUTICALS, LLC

PHR: PROJECT NARRATIVE The management of pain following surgery remains an area of clear unmet medical need. The goal of this project is to validate an approach to advance a novel, non-opioid drug candidate for the treatment of postoperative pain.

PI_NAMEs: DOUGHERTY, PATRICK M (contact);KOGAN, YAKOV

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Accounting;Acute Pain;addiction;adverse outcome;allodynia;Analgesics;Animals;Apolipoprotein A-I;Area;Behavior;Behavioral;Binding;Binding Proteins;Biological Assay;Biological Markers;Blood;Cancer Center;Cancer Patient;cancer survival;Cell membrane;Cells;Chemotherapy-induced peripheral neuropathy;Cholesterol;chronic pain;Clinic;clinical development;Clinical Trials;Contralateral;cost;Cyclic GMP;Data;Data Set;Day Surgery;Dependence;dermatome;Development;Development Plans;Dose;drug candidate;Drug Kinetics;efficacy study;Excision;Female;first-in-human;Formulation;Fright;Funding;Future;Generations;Goals;Harvest;Hospitals;Human;Human Activities;Hyperactivity;immunogenicity;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Injury;Intravenous;intravenous injection;Ipsilateral;Laboratories;Link;Macrophage;male;manufacture;Mediating;Medical;Membrane;Membrane Lipids;Membrane Microdomains;Methods;Microglia;Modeling;nerve injury;neuroinflammation;Neurons;Nociception;Nociceptors;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;Operative Surgical Procedures;Opioid;Organ;Pain;Pain management;pain model;pain relief;Patients;Perioperative;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Postoperative Pain;pre-Investigational New Drug meeting;Prevalence;prevent;Procedures;Process;Protocols documentation;Publishing;Quality of life;Rattus;Regulation;Reporting;response;Safety;safety assessment;safety study;safety testing;Secondary to;Sensory;sex;Sex Differences;Side;side effect;Site;Small Business Technology Transfer Research;Source;Spinal;Spinal Cord;Spinal Ganglia;spontaneous pain;Surgical incisions;Surgical Injuries;System;Tactile;Testing;Therapeutic;Time;tissue injury;TLR4 gene;Toxicology;Translating;Variant;Withdrawal;Work;wound

PROJECT_TITLE: Targeting TLR4-lipid rafts to prevent postoperative pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: NOVUS VISION LLC

ORG_STATE: MD

PHR: PROJECT NARRATIVE Novus Vision Inc. is developing a novel eye drop drug delivery technology, OcuGel, that has promise for providing longer-lasting and more effective drug delivery to the anterior and posterior segments to treat a variety of ophthalmic diseases. Here, we describe preclinical development work to reformulate a brimonidine OcuGel eye drop as a pharmaceutically appropriate, shelf stable, repeat use formulation for once daily dosing to treat glaucoma. At the end of the project period, we will have an appropriate data package for an IND submission to continue development.

PI_NAMEs: ENSIGN, LAURA ;HSUEH, TUNG HENG  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: absorption;Acceleration;Acids;Acute;Adherence;Aliquot;alpha 2 agonist;Anterior;Area Under Curve;Award;Benzalkonium Chloride;Biological Sciences;Blindness;Borates;Brimodine;Buffers;chlorine dioxide;Chronic;clinical development;Contracts;Data;density;Development;Disease;Dose;Drops;Drug Delivery Systems;Dry Eye Syndromes;Evaluation;Eye;eye dryness;Eyedrops;Feedback;Film;Formulation;Frequencies;Gel;Glaucoma;High Pressure Liquid Chromatography;Hour;Industry;Industry Standard;inorganic phosphate;International;Label;Lasers;Legal patent;Licensing;Light;Liquid substance;Lubrication;Marketing;Measurement;Miniature Swine;neuroprotection;novel;ocular surface;ocular surface disease;Optics;Oryctolagus cuniculus;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;phase 2 study;Physiologic Intraocular Pressure;pre-Investigational New Drug meeting;Precipitation;preclinical development;preclinical safety;preservation;prevent;Prostaglandins;Recommendation;reduce symptoms;residence;retinal toxicity;risk mitigation;Safety;safety testing;sodium chlorite;stability testing;Sterility;sterility testing;success;Surface;surface coating;Symptoms;System;systemic toxicity;Tartrates;Technology;Temperature;Testing;Thinness;Time;Tissues;Toxic effect;Trabeculectomy;Universities;Viscosity;Vision;Water;Work

PROJECT_TITLE: Pharmaceutical development of longer-lasting brimonidine eye drops

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

PHR: NARRATIVE – PROJECT 2 Project 2 will develop a renewable human gastric tissue culture model that represents stages of pre-neoplastic progression. Investigators will be able to study and induce changes in gastric stem cells with the hopes of understanding the mechanisms behind cancer development.

PI_NAMEs: AMIEVA, MANUEL R (contact)

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Antibiotics;Apical;Atrophic;Bacterial Genes;Basic Science;Behavior;Biological;Biology;Biopsy;Cancer Etiology;carcinogenesis;Carcinoma;Categories;Cell Communication;Cell model;Cell Polarity;Cellular biology;Cessation of life;Chronic;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Confocal Microscopy;Correa cascade;Data;Development;Disease Progression;DNA Sequence Alteration;Dysplasia;Endoscopic Biopsy;Epithelial Cells;epithelial stem cell;Epithelium;Experimental Models;experimental study;Exposure to;fitness;Gastric Glands;gastric intestinal metaplasia;gastric organoids;Gastric Tissue;Gastritis;Gene Expression;Gene Expression Profile;gene-editing approach;Genes;genetic selection;Genotype;Gland;Growth;Helicobacter Infections;Helicobacter pylori;high risk;Human;human tissue;Immune response;improved;In Situ;In Vitro;Infection;Inflammation;Inflammatory;insight;Intestines;Laboratory Research;Lesion;Libraries;Location;Malignant Neoplasms;malignant stomach neoplasm;Measures;Methods;Microscopy;Modeling;Molecular;Monitor;mortality;Mutation;neoplastic;next generation sequencing;novel;Organoids;Pathogenesis;Patients;Peptide Initiation Factors;Persons;Phenotype;Precancerous Conditions;premalignant;Process;programs;Property;Quantitative Microscopy;Recrudescences;Research;Research Personnel;Resolution;Resources;response;Risk;Risk Factors;Risk Marker;risk stratification;Role;Sampling;single cell genomics;single-cell RNA sequencing;Site;stem;stem cell niche;stem cell organoids;stem cell population;stem cells;stemness;Stomach;Stomach Carcinoma;Surface;System;Techniques;Testing;Time;tissue culture;Tissue Model;Tissues;tumor progression;Tumor Stem Cells;Virulence Factors;Visualization

PROJECT_TITLE: Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Clathrin-mediated endocytosis is the primary route of internalization from the plasma membrane and is required for cell viability and the proper response to extracellular cues like growth factor signaling. Mutations in the endocytic machinery, or the proteins that regulate this process, lead to a variety of diseases like cancer and neurodegeneration. This research will take an interdisciplinary approach to understand the mechanisms of endocytic initiation and cargo selection to understand CME in normal cells and how it is subverted in human disease.

PI_NAMEs: BAKER, RICHARD WAYNE (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Area;Automobile Driving;Binding;Biochemical;Cell membrane;Cell Physiology;Cell Survival;Clathrin;Clathrin Adaptors;Coated vesicle;Complex;Cryoelectron Microscopy;Cues;Data;Decision Making;Defect;Development;Disease;disease model;drug development;Endocytosis;enhancer-binding protein AP-2;Environment;experimental study;extracellular;Fluorescence Microscopy;G-Protein-Coupled Receptors;Growth Factor;human disease;insight;interdisciplinary approach;Lead;live cell imaging;Malignant Neoplasms;Mediating;Medical;Membrane;Methodology;Modeling;Molecular;Molecular Conformation;Mutation;Nature;Nerve Degeneration;Normal Cell;Nutrient;Phosphorylation;Process;Protein Family;Proteins;Quality Control;reconstitution;Regulation;Research;response;Role;Route;Signal Transduction;single molecule;Sorting;Systems Development;uptake;Vesicle

PROJECT_TITLE: Molecular mechanisms of endocytic initiation and cargo selection


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ROME

ORG_COUNTRY: ITALY

ORG_FIPS: IT

ORG_NAME: FOOD & AGRICULTURAL ORG/UNITED NATIONS

PHR: Project narrative The main objective of this project is to implement a complementary set of capacity building actions, at global level and in a number of selected countries focusing on risk-based practices and overall comprehensive assessments of food control systems to improve national food control frameworks. Risk-based approaches to food control and identification of the weaknesses in the food control system help minimizing exposure to food hazards, while making more efficient use of the available resources, that may be scarce for many developing or transition countries. In the development and delivery of this project, high importance is placed on coherence with other activities, both in FAO and beyond, to support an optimal and a sustainable outcome, while linkages will be ensured between the technical and the political frameworks to facilitate policy changes based on the improved understanding about where the risks lie.

PI_NAMEs: BESSY, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, KEVIN

PROJECT_TITLE: Strengthening global food safety through improved capacities for food control at regional and country levels


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: BIOLOGY

PHR: Narrative Over the course of human evolution, a complex process of genetic inheritance across diverse human populations has given rise to intricate patterns of statistical association between genetic variants and common complex diseases. Population-based studies that assess the genomes of large samples of unrelated cases and controls offer a powerful approach for identifying common disease risk variants, primarily those for which risk is conferred by possessing a single copy of a risk allele. Our project will leverage models from human population genetics to provide methods and software that will accelerate the discovery and characterization of rare, recessive genetic factors—for which risk is conferred by possession of two copies of the risk variant— addressing challenges arising from large data sets, complex genome sequencing projects, and the effort to find disease variants in underrepresented populations.

PI_NAMEs: ROSENBERG, NOAH  (contact);SCHEET, PAUL A;ZOELLNER, SEBASTIAN

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Acceleration;Achievement;Address;Admixture;Affect;Algorithms;Alleles;biobank;Calibration;cancer risk;Chromosome abnormality;cohort;Collaborations;Collection;Complex;Computer software;Copy Number Polymorphism;Data;Data Set;Demography;design;Detection;Disease;disorder risk;European;Evolution;Explosion;Frequencies;Funding;gene environment interaction;Gene Frequency;gene interaction;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Models;Genetic Phenomena;Genetic Processes;Genetic Structures;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Germ Lines;Growth;Haplotypes;Historical Demography;Homozygote;Human;human disease;Human Genetics;human population genetics;human population study;Inbreeding;Individual;Inherited;insight;Investigation;large datasets;Large-Scale Sequencing;Length;Link;Linkage Disequilibrium;Loss of Heterozygosity;Measures;Medical;Mendelian disorder;Methods;Michigan;Modeling;mosaic;Natural Selections;novel strategies;Partner in relationship;Pattern;Phase;phenome;Phenotype;Play;Population;population based;Population Distributions;Population Genetics;Population Heterogeneity;Population Sizes;Population Study;preference;Productivity;programs;Quality Control;Rare Diseases;rare variant;recessive genetic trait;Recording of previous events;Reporting;Research Design;Research Personnel;Risk;risk variant;Role;Running;Sampling;Signal Transduction;Statistical Data Interpretation;Structure;success;Techniques;Testing;Theoretical model;tool;trait;Underrepresented Populations;user friendly software;Variant;whole genome

PROJECT_TITLE: Population genetics for large-scale sequencing studies of diverse populations

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

PHR: NARRATIVE – PROJECT 3 This project is geared towards developing better ways of detecting stomach cancer in its earliest stages when there is a high chance of cure. This research will lead to ways of reducing the risk of developing stomach cancer.

PI_NAMEs: HWANG, JOO HA (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;adjudication;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;arm;Back;Biological Assay;Biological Specimen Banks;Biology;biomarker panel;Biopsy;Blinded;cancer risk;Carcinoma;cell type;Chile;Chromosome Mapping;Clinical;clinical data repository;Clinical Management;cohort;Cohort Studies;design;Detection;Development;Diagnosis;DNA Sequence Alteration;Dysplasia;Endoscopy;Enrollment;Epithelial Cells;Epithelium;Evaluation;experience;expression vector;Gastric Adenocarcinoma;Gastric Glands;gastric intestinal metaplasia;Gastric Tissue;gastrointestinal;Gene Expression;Gene Expression Profile;Genetic;Genomics;Gland;Goals;Helicobacter Infections;Helicobacter pylori;high risk;Histologic;histological specimens;Histology;Histopathology;human subject;Immunohistochemistry;improved;Individual;Intervention;Label;Lesion;Link;Machine Learning;Malignant Neoplasms;malignant stomach neoplasm;Methods;Molecular;Mucous Membrane;Network-based;neural network;novel;Organism;Outcome;Pathologist;patient subsets;Patients;Pattern;Placebos;Precancerous Conditions;premalignant;Prevalence;prevent;Prognostic Marker;Program Research Project Grants;progression risk;Randomized;randomized placebo controlled trial;Recrudescences;recruit;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;risk stratification;Sampling;Severities;Slide;Specimen;Stains;Stomach;Surrogate Endpoint;Techniques;Technology;Testing;Training;transcriptome sequencing;Translating;tumor;tumor progression;Universities;Work

PROJECT_TITLE: Project 3: Molecular Risk Stratification of Gastric Precancerous Lesions


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative The function of macromolecules involves dynamic interactions with other molecules, so studying their structural variability is often key to understanding their functioning mechanism. In this proposal, we will develop novel computational methods that analyze the structural heterogeneity of proteins imaged by CryoEM and CryoET. Using the Gaussian mixture model for protein structure representation and deep neural network for constructing the conformation space, the software tools will provide a more comprehensive view of the dynamic of macromolecular systems.

PI_NAMEs: CHEN, MUYUAN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Amino Acid Sequence;Behavior;Biochemistry;Biological Process;biological systems;Cells;Classification;combat;Complex;computerized data processing;computerized tools;Computing Methodologies;cost;Cryoelectron Microscopy;cryogenics;Data Set;deep neural network;density;dynamic system;electron tomography;Environment;Exercise;flexibility;Gaussian model;Goals;Heterogeneity;Homologous Protein;Ice;Image;In Situ;Individual;innovation;insight;Knowledge;macromolecule;Maps;Memory;Methods;microscopic imaging;Modeling;Modernization;Molecular Conformation;molecular modeling;Movement;Noise;novel;particle;Property;Protein Analysis;protein complex;Protein Conformation;protein structure;Proteins;Protocols documentation;Research Personnel;Resolution;Rotation;Sampling;Signal Transduction;Software Tools;structural biology;Structure;Structure-Activity Relationship;Sum;System;Tomogram;Visualization;Work

PROJECT_TITLE: Comprehensive analysis of macromolecule structural variability in CryoEM/CryoET

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: UCSF Helen Diller Family Comprehensive Cancer Center: Narrative The UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) seeks to drive scientific discovery and develop tailored interventions to improve cancer outcomes in the catchment area and beyond. This mission, established through a unique strategic planning process, encompasses three Center-wide themes that are integrated throughout the HDFCCC and will drive research into the next decade and thereafter: Impactful Discovery, Effective Translation, and Implementation and Dissemination.

PI_NAMEs: ASHWORTH, ALAN  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: anti-cancer research;Area;Automobile Driving;Awareness;Basic Science;Biological;California;Cancer Center Support Grant;Caring;Catchment Area;Characteristics;Clinical;Clinical Research;Communities;community engagement;Comprehensive Cancer Center;Data;Dedications;Development;Diagnosis;Disease;Dissemination and Implementation;Early Diagnosis;Ensure;Environment;equity, diversity, and inclusion;Family;Funding;Health;improved;improved outcome;Individual;Inequity;Infrastructure;innovation;insight;Intervention;Location;Malignant Neoplasms;member;Mission;Outcome;Patient-Focused Outcomes;Population;Population Heterogeneity;Population Research;Population Sciences;Prevention;Process;programs;Research;Research Support;Resource Sharing;Risk;San Francisco;Science;screening;Strategic Planning;Training and Education;Translating;Translations;treatment center;Treatment outcome;Universities

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SHUMATE, KATE TAYLOR (contact)

PROJECT_TERMS: Award;Cancer Center Support Grant;Collaborations;Contracts;Data Collection;data management;Ensure;Equipment;Evaluation;Goals;Grant;Health;Human Resources;Infrastructure;Leadership;Malignant neoplasm of prostate;medical schools;member;Mentored Clinical Scientist Development Program;Mission;Occupational activity of managing finances;Operations Research;Positioning Attribute;prevent;Production;programs;Progress Reports;Research;Research Activity;Resource Allocation;Resources;Schools;Services;Strategic Planning;Training and Education;Universities;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATVE Aggressive variant prostate cancers (AVPC) respond to carboplatin+cabazitaxel but remain with a poor prognosis. We propose a tissue-rich clinical trial, and co-clinical studies in mice, combining ADI-PEG20 (which depletes serum arginine levels) with carboplatin+cabazitaxel to evaluate the safety, efficacy and effects of this combination on intratumoral metabolites, signaling pathways, and immune profiles of the AVPC tumor microenvironment. The results of these studies will serve to inform further rational combinations for the treatment of the AVPC.

PI_NAMEs: APARICIO, ANA  (contact);FRIGO, DANIEL EDWARD;SHARMA, PADMANEE

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;advanced prostate cancer;androgen independent prostate cancer;Androgens;anti-PD-1;Antibodies;Antitumor Response;Arginine;Arginine deiminase;argininosuccinate synthase;Biological Markers;biomarker identification;Biopsy;Cancer Biology;Carboplatin;CD8-Positive T-Lymphocytes;Cell model;Cell Physiology;Cells;chemotherapy;Citrulline;Clinical Data;Clinical Research;Clinical Trials;Combination Drug Therapy;Combined Modality Therapy;Cytotoxic Chemotherapy;Data;Development;digital;Disease;Dose;effective therapy;effector T cell;Elements;Enzymes;Epithelium;Evaluation;experimental study;extracellular;Goals;Human;Immune;Immune system;Immunohistochemistry;Immunology;immunoregulation;improved;inhibitor;Ions;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Chromatography;Mass Spectrum Analysis;Measures;Mediating;men;Metabolic Pathway;Metabolism;mouse model;Mus;Neoplasm Metastasis;Nitric Oxide;Outcome;Participant;Pathway interactions;Patients;peripheral blood;Phagocytosis;Phase;Phase I/II Trial;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Polyamines;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;Prognosis;prospective;prostate cancer cell;prostate cancer cell line;Proteins;Reporting;response;Role;Safety;Sampling;Series;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Subjects Selections;synergism;T cell infiltration;targeted treatment;taxane;Technology;Time;Tissues;treatment effect;trial design;tumor;tumor metabolism;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Variant;Vertebral column;Virulence

PROJECT_TITLE: Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Precision Medicine;Prevention;Rare Diseases;Stomach Cancer

PHR: NARRATIVE – ADMINISTRATIVE CORE A The objective of the Project Program Grant (PPG) is to improve precision cancer prevention for patients with a high likelihood of developing gastric malignancies. To achieve this goal, the PPG will rely on a centralized operational, fiscal and regulatory support system. Core A will streamline managing the administrative components of the research program and enables the PPG to be successful in achieving its goal of improving prevention of stomach cancer.

PROJECT_TERMS: Budgets;Clinical;Clinical Trials;Collaborations;Communication;Communities;Conflict of Interest;Consent Forms;cost effectiveness;Data;data dissemination;data resource;data sharing;database of Genotypes and Phenotypes;Development;Ensure;Expenditure;Fostering;Funding;gastric cancer prevention;Goals;Grant Review;Guidelines;Human Resources;improved;Institution;Institutional Review Boards;Intercept;interdisciplinary collaboration;malignant stomach neoplasm;Manuscripts;meetings;member;Mission;Molecular;Monitor;multidisciplinary;Occupational activity of managing finances;Office of Administrative Management;online resource;Patients;precision cancer prevention;precision medicine;Productivity;Program Research Project Grants;programs;Protocols documentation;Quality Control;recruit;Reporting;Research;Resource Sharing;Resources;risk stratification;Sampling;Services;Supervision;Support System;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Core A: Administrative


PI_NAMEs: NGUYEN, TUNG T. (contact)

PROJECT_TERMS: Accountability;Address;Affect;anti-cancer research;Cancer Center Support Grant;career;career development;Catchment Area;Collaborations;community engagement;Community Outreach;community partnership;Data;Dedications;Disabled Persons;diversity and equity;Elements;Ensure;Equity;equity, diversity, and inclusion;Faculty;flexibility;Fostering;Goals;graduate student;Health;improved;Income;Individual;Inequity;Infrastructure;Institution;Leadership;Malignant Neoplasms;Mentors;Monitor;Occupations;Outcome;Persons;Population Heterogeneity;Procedures;Productivity;recruit;Research;Research Personnel;Resources;Science;social health determinants;Structure;System;Training;Training and Education;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Rare Diseases;Stomach Cancer

PHR: PROJECT NARRATIVE – CELLULAR IMAGING AND GENOMICS CORE B Core B's experimental processing services will determine the cellular and genomic features defining high risk gastric precursors. The core will support experimental models to define the underlying biology. By providing a range of sophisticated imaging, molecular and sequencing assays, the core will streamline the progress of the Program Project Grant and its goal of advancing precision cancer detection.

PROJECT_TERMS: 16S ribosomal RNA sequencing;Achievement;Antibodies;automated analysis;Biological Assay;Biology;Biometry;Biopsy;Cancer Detection;Cell Physiology;Cells;Cellular Assay;cellular imaging;Chromatin;Clinical Trials;cohort;Confocal Microscopy;Data;Data Analyses;data management;data repository;Data Set;database of Genotypes and Phenotypes;Detection;DNA sequencing;Ensure;Epigenetic Process;experience;experimental analysis;Experimental Models;follow-up;Future;gastric organoids;Gastric Tissue;Generations;Genetic;genetic profiling;genomic data;Genomic Library;Genomics;Goals;Helicobacter pylori;high risk;human tissue;Image;image archival system;imaging study;Imaging Techniques;Immunohistochemistry;Individual;Laboratories;Leadership;Learning;Libraries;Malignant Neoplasms;malignant stomach neoplasm;Management Information Systems;Metadata;Methods;microscopic imaging;Molecular;Molecular Analysis;Molecular Genetics;Multiomic Data;next generation sequencing;Organoids;Pathologic;pathology imaging;Precancerous Conditions;premalignant;Preparation;Process;Production;Program Research Project Grants;programs;Protocols documentation;Quality Control;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;risk stratification;Sampling;Sampling Studies;Sequence Read Archive;Services;single cell genomics;single-cell RNA sequencing;Stains;Standardization;Stomach;Structure;System;Techniques;Technology;tissue culture;tissue processing;Tissue Sample;Tissues;transcriptome sequencing;transcriptomics;translational study;Transposase;United States National Institutes of Health;wasting;Work

PROJECT_TITLE: Core B: Translational, Cellular and Molecular Analysis


PROJECT_TERMS: American Society of Clinical Oncology;anti-cancer research;APBA1 gene;Area;Biomedical Research;Body mass index;Breast;Cancer Center Support Grant;career development;Caring;Clinical Oncology;Collaborations;college;Communities;community engagement;Community Outreach;Data;design;Development;Dissemination and Implementation;Diverse Workforce;Education;educational atmosphere;Educational workshop;Ensure;equity, diversity, and inclusion;experience;Faculty;Fostering;Future;girls;Goals;Grant;Health education;Health Professional;Healthcare;high school;Individual;interest;Interest Group;Internships;K-Series Research Career Programs;Leadership;Malignant Neoplasms;member;Mentored Clinical Scientist Development Program;Mentors;Mission;neurosurgery;Oncology;Oncology Group;patient oriented;Play;Program Development;programs;Research;Research Personnel;Research Training;Resource Sharing;Resources;Role;Science;science education;Series;Site Visit;skills;skills training;Strategic Planning;success;summer internship;Training;Training and Education;Training Programs;Translations;Travel;Underrepresented Populations;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Narrative Advanced computational methods are needed to obtain comprehensive mechanistic understanding of the regulation of substrate transport via membrane transporter proteins. The research projects pursued in the PI's lab employ a synergistic combination of experiments, computational modeling and data-driven approaches to investigate neurotransmitter and sugar transporters.

PI_NAMEs: SHUKLA, DIWAKAR  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: algorithm development;Algorithms;Carrier Proteins;Cells;Computer Models;Computing Methodologies;conformational conversion;Coupled;Coupling;Data;Data Set;deep learning;Development;Emerging Technologies;Experimental Designs;experimental study;Fluorescence;Free Energy;G-Protein-Coupled Receptors;improved;in silico;In Vitro;Investigation;Ion Cotransport;Ions;Kinetics;Libraries;machine learning algorithm;Measures;Membrane Proteins;Membrane Transport Proteins;Methods;Modeling;Molecular Conformation;molecular dynamics;monoamine;Mutagenesis;mutant;Mutation;mutation screening;Neurons;Neurotransmitter Receptor;neurotransmitter transport;Neurotransmitters;Pathway interactions;programs;Protein Conformation;protein function;protein structure;Proteins;Regulation;Research;Research Project Grants;Resolution;Role;simulation;Site;Sodium;Sorting;Structure;success;sugar;Techniques;transfer learning;Variant

PROJECT_TITLE: Elucidating sequence, structural and dynamic basis of the functional regulation of membrane proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases;Stomach Cancer

PHR: NARRATIVE – BIOSTATISTICS CORE C The large scale of genomic and clinical data that will be generated by the Program Project Grant (PPG) offers innumerable opportunities. The Biostatistics Core is advantageously positioned to develop study designs and novel computational methods which will ensure completion of the research projects within the PPG and serve as lasting scientific resources for the broader biomedical community.

PI_NAMEs: HAN, SUMMER S (contact)

PROJECT_TERMS: Address;Administrative Personnel;Advanced Development;Basic Science;Bioinformatics;Biological;biomedical data science;biomedical informatics;Biometry;Biostatistics Core;cancer genomics;cellular imaging;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Communities;Computing Methodologies;Data;Data Analyses;Data Collection;data harmonization;data management;data repository;Data Scientist;Data Set;data standards;design;Development;Elements;Ensure;Environment;Epidemiologist;Equity;experience;Experimental Designs;experimental study;follow-up;Formulation;Genetic;genomic data;Genomics;Genotype;Goals;Grant;Housing;human data;human subject;human tissue;Image;Infrastructure;innovation;Institution;interdisciplinary approach;Intervention;Laboratory Study;Maintenance;malignant stomach neoplasm;medical schools;meetings;member;Methods;mid-career faculty;Mission;Molecular;next generation sequencing;novel;Observational Study;open source;Output;Pathway interactions;Patient Monitoring;Phenotype;Play;Policies;Positioning Attribute;pre-clinical;prevent;Procedures;Program Research Project Grants;Publications;Randomized;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;risk stratification;Sample Size;Science;Secure;Services;single cell analysis;single cell genomics;Specialist;Statistical Data Interpretation;Statistical Methods;Structure;Supervision;Talents;Technology;Translational Research;United States National Institutes of Health;Universities;web-based tool

PROJECT_TITLE: Core C: Biostatistics


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: GOGA, ANDREI  (contact)

PROJECT_TERMS: Adverse effects;Area;Award;Biology;Breast;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast lesion;Breast Oncology;Cancer Burden;Cancer Center Support Grant;cancer risk;cancer therapy;Catchment Area;Cells;Classification;Clinical Engineering;Clinical Research;Clinical Trials;cohort;combinatorial;Communities;community engagement;demographics;Development;Diagnosis;Disease;disorder risk;Drug Combinations;drug development;Elements;Ensure;Ethnic Origin;Extracellular Matrix;Genetic;Goals;Healthcare;Heterogeneity;high risk;improved;improved outcome;Individual;individualized medicine;Inflammation;innovation;insight;Intervention;Laboratories;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammographic screening;Measures;member;Methodology;Methods;Modeling;Molecular;mortality;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Noninfiltrating Intraductal Carcinoma;novel;novel therapeutic intervention;Oncogenic;oncology program;Outcome;outcome disparities;Participant;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;personalized intervention;personalized screening;Pharmaceutical Preparations;Phase;Population;predicting response;Predisposition;Prevention;Prevention Measures;Process;programs;Race;recruit;Regimen;Research;response;Risk;Risk Assessment;Risk Reduction;routine screening;Safety;screening;Site;study population;success;Testing;Therapeutic;therapy resistant;Time;Tissues;Training and Education;Treatment outcome;trial design;tumor;tumor heterogeneity;Tumor Tissue;Woman;Work

PROJECT_TITLE: Breast Oncology Program


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed study will test of the influence of two individual difference factors, motivation for alcohol and cognitive control, on alcohol use and problems in young adults making the transition to legal drinking (i.e., the 21st birthday). The study will examine how these processes contribute to the increase in alcohol problems, especially alcohol-impaired driving, that is known to occur in the year after the 21st birthday. Knowledge gained from this research will inform efforts to reduce alcohol-related problems in young adult drinkers.

PI_NAMEs: BARTHOLOW, BRUCE D (contact);MCCARTHY, DENIS M

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: 21 year old;Accounting;Acute;addiction;Affect;Age;Alcohol abuse;alcohol availability;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol involvement;alcohol related problem;alcohol seeking behavior;Alcohols;Area;Behavior;Behavioral;Censuses;Characteristics;Chronic;cognitive control;Cognitive Science;cognitive system;college;contextual factors;Data;Databases;Decision Making;design;Desire for food;Development;drinking;driving behavior;Drunk driving;effective intervention;Etiology;executive function;experience;experimental study;Failure;Family;follow up assessment;Heterogeneity;high risk;improved;indexing;Individual;Individual Differences;Influentials;innovation;Intoxication;Knowledge;Legal;Licensing;Life;Link;Measurement;Measures;Methodology;minimum drinking age;Missouri;Modality;Modeling;Motivation;multimodality;neurobehavioral;neurophysiology;Outcome;Participant;Patient Self-Report;peer;Persons;Population;predictive modeling;Prevention;Process;Public Health;Questionnaires;Recording of previous events;recruit;remediation;Reporting;Research;Risk;Role;Rural;Sampling;sobriety;Societies;standard measure;Structure;Testing;trait;Work;young adult

PROJECT_TITLE: A rigorous test of dual process model predictions for problematic alcohol involvement


NIH_SPENDING_CATS: Clinical Research;Dystonia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Blepharospasm is a neurological disorder characterized by over-activity of the muscles around the eyes, leading to excessive blinking, eye spasms, impaired eyelid opening, and sometimes involvement of the lower face and jaw. In the current studies, we describe a multifaceted approach for the detection, discrimination, and measurement of these different problems, so that they can be better studied.

PI_NAMEs: JINNAH, HYDER A (contact);YEO, WOON-HONG

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TITLE: Deep phenotyping in blepharospasm

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE After learning, new memories are consolidated, which relies on transferring information from the hippocampus to the cortex. This project aims to understand how hippocampal inputs and local circuit dynamics in the prefrontal cortex interact to support memory consolidation. Thus, this proposal will lead to a critical understanding of the mechanisms of memory processing that will provide insight into how memories are consolidated in the cortex for long-term storage.

PI_NAMEs: ROBINSON, HEATH LARSSON (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Behavior;Behavioral;Brain region;cell type;cognitive function;Communication;Computer Analysis;Control Groups;educational atmosphere;Electrophysiology (science);Event;Evolution;experience;experimental study;Hippocampus;Impairment;Implant;in vivo;insight;Interneurons;Learning;Life;Light;long term memory;Memory;memory consolidation;memory encoding;memory process;memory recall;memory retrieval;Mission;Modification;Monitor;Mus;National Institute of Mental Health;neural;Neurons;neurophysiology;optical fiber;optogenetics;Output;Parvalbumins;Pattern;Performance;Physiological;Play;Prefrontal Cortex;Process;Property;Pyramidal Cells;Research Project Grants;Role;Short-Term Memory;Silicon;spatial memory;Structure;Synaptic plasticity;System;Testing;Time;Transgenic Mice;Tungsten;Work

PROJECT_TITLE: Prefrontal cortical circuit reorganization during immediate memory consolidation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: LING, PAMELA MAY (contact)

PROJECT_TERMS: Address;African American;Attention;Behavioral;Biological;Cancer Biology;Cancer Burden;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer health equity;cancer prevention;cancer risk;Caring;Catchment Area;Cells;Cigar;Cigarette;Clinical;Clinical Practice Guideline;Communities;community based participatory research;community engagement;Data;Electronic cigarette;Equity;Etiology;Evidence based intervention;Geography;Goals;Health;Health Disparities Research;health equity;Health equity research;health inequalities;Health Policy;improved;Incidence;Individual;Industrialization;Intervention;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;men;Menthol;multidisciplinary;neoplasm registry;novel;Outcome;Physical activity;Policies;Policy Research;Population;population based;Population Heterogeneity;Positioning Attribute;Prevention;programs;public policy on tobacco;Regulation;Research;Resources;Risk;Risk Factors;Sales;San Francisco;Science;screening;Screening for cancer;social;social determinants;Societies;Source;structural determinants;Structural Racism;survivorship;System;Testing;tobacco flavor;tobacco products;Tobacco use;tool;Training and Education;Translating

PROJECT_TITLE: Cancer Control Program


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative In this study, the DISCOVER (Digital Innovation, Simulation, and Collaboration using Virtual Environment Realities) for Pediatric Diagnostic Excellence Learning Lab we will build a patient safety learning lab combining the expertise of LiveWell, a design collaborative with user-centered design and human factors expertise, with the clinical knowledge, implementation science expertise, and world-renowned virtual simulation program of Cincinnati Children’s Hospital Medical Center. This learning lab will use systems engineering methodology to envision, develop, prototype and test design-informed clinical decision support approaches to improving diagnosis in an existing highly immersive virtual clinical world.

PI_NAMEs: DEWAN, MAYA L (contact);ZACKOFF, MATTHEW WILLIAM

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Digital Innovation, Simulation, and Collaboration using Virtual Environment Realities (DISCOVER) for Pediatric Diagnostic

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The gene regulation processes by which an olfactory sensory neuronal progenitor goes from co-expressing multiple olfactory receptor genes to monogenic, monoallelic choice of olfactory receptor genes in mature olfactory sensory neurons needs to be further elucidated. Tex15 is transiently expressed during the critical gene regulation window in olfactory sensory neuronal progenitors, and we hypothesize that Tex15 is regulating monoallelic olfactory receptor gene choice through either methylation patterns or through its effect on chromatin state of developing olfactory sensory neurons. Through this study, I will be trained on cutting-edge molecular, cellular and computational neuroscience approaches to answer some of the broader questions of the field of olfactory sensory neuron gene expression and gene regulation patterns.

PI_NAMEs: YUSUF, NUSRATH  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adolescent;Alleles;Binding;Binding Proteins;Biochemical;chemical binding;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;Complex;computational neuroscience;Data;Deposition;Detection;Development;DNA Methylation;DNA methylation profiling;DNA Transposable Elements;Down-Regulation;Elements;Ensure;Environment;Epigenetic Process;Excision;experimental study;Faculty;Fellowship;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genetic Transcription;genome-wide;Genomics;Heterochromatin;histone demethylase;histone methyltransferase;Histones;innovation;insight;KDM1A gene;Knock-out;Knockout Mice;link protein;Mammals;Maps;Mediating;Mentorship;Methylation;methylation pattern;Molecular;Mus;mutant;Mutant Strains Mice;nerve stem cell;Nervous System;Neuronal Differentiation;novel;Nuclear;Odorant Receptors;Olfaction Disorders;Olfactory Epithelium;olfactory receptor;olfactory sensory neurons;Pattern;Perception;Phenotype;piRNA;Process;programs;promoter;Proteins;receptor expression;Receptor Gene;recruit;Repression;Rest;Role;Sensory;Shapes;single-cell RNA sequencing;Smell Perception;Specificity;Spermatocytes;Students;Techniques;Testing;Testis;Training;Transcriptional Silencer Elements;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: The role of Tex15 in shaping stochastic olfactory receptor gene choice.


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative In this project, we will conduct exome-wide discovery efforts to identify rare variants and genes that contribute to risk of prostate cancer and aggressive disease in men of European, African, Asian and Latino ancestry. We expect findings from this study will make a major contribution to our understanding of genetic susceptibility to prostate cancer and will have widespread applicability and significance, leading to better risk models to more accurately predict a man's risk of developing prostate cancer and aggressive disease.

PI_NAMEs: HAIMAN, CHRISTOPHER ALAN (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: African;African ancestry;Alleles;Allelic Imbalance;Asian;Asian ancestry;biobank;Biological;Biology;BRCA2 gene;Cancer Patient;Candidate Disease Gene;CHEK2 gene;Clinical;clinical translation;Code;cohort;cost;Data;density;Development;Diagnosis;Disease;disease phenotype;Disease susceptibility;disorder risk;diverse data;DNA Repair Pathway;driver mutation;European;European ancestry;exome;Family history of;Frequencies;Gene Expression Profile;Gene Frequency;Genes;Genetic Predisposition to Disease;Genetic Risk;Genetic Variation;Genome;genome wide association study;genome-wide;Germ Lines;Germ-Line Mutation;Gleason Grade for Prostate Cancer;Heritability;Heterogeneity;high risk;Hispanic;Latino;Malignant neoplasm of prostate;man;men;Metastatic Prostate Cancer;Minor;Modeling;Modification;Mutate;Mutation;novel;PALB2 gene;Pathogenicity;Pathway interactions;personalized risk prediction;Phenotype;polygenic risk score;Population;prevent;prospective;prostate cancer prevention;prostate cancer risk;Protein Truncation;Proteins;rare variant;Reporting;Resources;Risk;risk variant;Sample Size;screening;Somatic Mutation;Surveys;Susceptibility Gene;Testing;Time;Trans-Omics for Precision Medicine;transcriptomics;tumor;Variant;whole genome

PROJECT_TITLE: Leveraging whole-exome sequence data from diverse biobanks and cohorts to study rare coding variation in prostate cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Acute seizures may evolve into status epilepticus (SE) which can result in irreversible brain injury or death and costs ~$4 billion per year to the US healthcare system. The QuITT-SE effectiveness-implementation hybrid trial utilizes quality improvement interventions and methods derived from a single-center project that improved outcomes in children and mitigated over $2 million in charges. By studying the effects of these interventions and their implementation across an established research consortium, we will develop and refine a standardized toolkit and implementation framework to improve the safety and value of SE treatment across diverse hospital settings.

PI_NAMEs: OSTENDORF, ADAM P. (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Academy;Acute;Address;Admission activity;Adoption;American;Anticonvulsants;Benzodiazepines;Brain Death;Brain Injuries;Caring;Categories;Cerebrum;Cessation of life;Charge;Child;Childhood;Cluster randomized trial;Conscious;cost;demographics;design;Diagnosis;Dose;effectiveness/implementation design;effectiveness/implementation trial;efficacy outcomes;evidence based guidelines;Evidence based intervention;Geography;Goals;Guidelines;Healthcare Systems;Hospital Costs;Hospitalization;Hospitalized Child;Hospitals;implementation determinants;implementation framework;improved;improved outcome;Individual;Intensive Care;Intervention;intervention effect;Measures;Mechanical ventilation;Methodology;Methods;Morbidity - disease rate;mortality;Neurology;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Performance;Phase;post implementation;Practical Robust Implementation and Sustainability Model;Process;process improvement;Public Health;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Refractory;Research;Resources;Safety;Seizures;Site;Societies;Standardization;Statistical Computing;Status Epilepticus;Testing;Time;United States

PROJECT_TITLE: Quality Improvement in time to Treatment of Status Epilepticus (QuITT-SE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


PI_NAMEs: FONG, LAWRENCE  (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Attention;Back;Biological Models;Biology;Blood;Brain Neoplasms;Cancer Center Support Grant;cancer immunotherapy;Catchment Area;Cell Therapy;cell type;Cells;checkpoint therapy;Clinic;Clinical;clinical application;clinical investigation;Clinical Investigator;community engagement;Complement;cytokine;Data;Development;Disparity;engineered T cells;Environment;Genetic Engineering;Goals;high dimensionality;Immune;Immune response;Immune system;Immunologic Surveillance;Immunology;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;interest;Laboratories;leukemia;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;member;Molecular;mouse model;Multiple Myeloma;Myelogenous;Myeloid Cells;Myeloproliferative disease;next generation;Non-Hodgkin's Lymphoma;novel;novel therapeutics;Patients;Population;Population Heterogeneity;Positioning Attribute;pre-clinical;programs;Regulatory T-Lymphocyte;Research;Resistance;resistance mechanism;response;Role;Sampling;Science;Scientist;T-Lymphocyte;Techniques;Technology;Therapeutic;Therapeutic Intervention;therapy resistant;Training and Education;Translating;Translational Research;translational study;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Cancer Immunology and Immunotherapy Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: SAINT PAUL

ORG_NAME: MYRIEL, INC.

ORG_STATE: MN

PHR: PROJECT NARRATIVE Myriel, Inc., is a pharmaceutical start-up company founded in 2022 whose goal is to find cures for tauopathies by developing small-molecule caspase-2 inhibitors that repair synapses by preventing the cleavage of the tau protein and increasing the number of functional AMPA receptors in dendritic spines. The goal of this Phase 1 STTR application is provide Myriel with a brain-penetrant analogue of our lead caspase-2 inhibitor, GPHR ‘739, by preparing prodrugs and validating the improvements in brain-penetration through pharmacokinetic studies.

PI_NAMEs: ASHE, KAREN H (contact);WALTERS, MICHAEL A.

PROJECT_TERMS: Academia;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;amidation;AMPA Receptors;analog;Antibodies;Back;blood-brain barrier crossing;Brain;Carboxylic Acids;CASP2 gene;Charge;Cholinesterase Inhibitors;Clinical Trials;cognitive function;Communication;Cyclization;Dementia;Dendritic Spines;Depressed mood;design;Disease;drug development;Drug Kinetics;Elderly;Esterification;experience;fatty acid amide hydrolase;Financial Support;Foundations;Frontotemporal Dementia;Frustration;Functional disorder;Future;General Population;Goals;human old age (65+);Impaired cognition;improved;inhibitor;innovation;Investigational Drugs;Ischemic Brain Injury;Lead;Letters;Lewy Body Dementia;Mediating;Medical;Medicine;Memantine;Membrane;Memory Loss;Metabolic;mild cognitive impairment;Modeling;Nature;Nervous System Disorder;Neurons;neuropathology;neurotransmission;Paper;Pathologic;Pathology;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;Phase II Clinical Trials;postsynaptic;Prevalence;prevent;Prodrugs;Protease Inhibitor;Publications;Qualifying;Rattus;receptor;repaired;Reproducibility;Research Personnel;Rodent Model;Route;Small Business Technology Transfer Research;small molecule;Specific qualifier value;Structure-Activity Relationship;Synapses;synaptic function;Synaptic Receptors;Synaptic Transmission;tau Proteins;Tauopathies;Therapeutic;Validation

PROJECT_TITLE: Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The recent explosion in biobanking, more routine collection of data on gender identity, and rapid expansion of research in transgender and gender diverse (TGD) populations has afforded both an opportunity to study whether gender identity has genetic underpinnings, and a time sensitive need to inform how such research is used to benefit and not harm TGD populations. In partnership with and guided by an Executive Stakeholder Board of diverse TGD community members, advocates, clinicians, and ethics, legal, and genomics and health equity scholars, we will explore potential risks and benefits of studying genomic associations with gender identity, host a summit to develop guidelines and recommendations for such research, and widely disseminate our findings. Our team will continue to serve as a national network to provide consultation and leadership in the expanding field of genomic research related to gender diverse populations.

PI_NAMEs: BAKER, KELLAN E.;HOROWITZ, CAROL R (contact);REISNER, SARI

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Address;Adult;Advocate;Ally;Area;Benefits and Risks;biobank;Birth;Categories;cisgender;Classification;Collaborations;Collection;Communication;Communities;community engagement;Complex;conflict resolution;Consultations;Data;Data Collection;Decision Making;design;Development;Disclosure;Discrimination;Disparity population;diverse data;ethical, legal, and social implication;Ethics;Ethnic Origin;Ethnic Population;Exclusion;experience;Explosion;Female;Gender;gender affirmation;gender confusion;gender diverse;gender diversity;gender expression;gender fluid;Gender Identity;gene editing technology;Genetic;genetic analysis;genetic variant;genomic data;Genomics;Geography;Goals;Guidelines;Harm Reduction;Health;health care delivery;health disparity populations;health equity;health inequalities;Health Services Accessibility;Individual;Institutional Review Boards;Interview;Knowledge;Laws;Leadership;Legal;Liquid substance;Literature;Lived experience;male;Measures;member;Mental Health;Methodology;Methods;Modeling;National Human Genome Research Institute;nonbinary;Participant;Pathology;Patient Self-Report;people of color;Persons;Phase;physical conditioning;Policies;polygenic risk score;Population;Population Heterogeneity;precision medicine;Process;Race;Recommendation;Reporting;Reproductive Technology;Research;Research Personnel;Research Priority;Review Literature;Risk;Scanning;Scientific Advances and Accomplishments;sex;sex assigned;Sex Orientation;Shapes;social stigma;Standardization;Stereotyping;Strategic vision;Surveys;symposium;Techniques;Terminology;Thinking;Time;transgender;unethical;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: Trans/Forming Genomics: Guidance for Research Involving Transgender and Gender Diverse People


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE As rates of depression in adolescent girls continue to rise, causing worsening disability and illness in this population worldwide, it is critical to investigate how social media use may amplify certain behaviors in ways that exacerbate vulnerability to depression. The overarching objective of the proposed project is to advance our knowledge of a potentially modifiable social media use behavior, intimate self-disclosure, and whether it represents a unique risk factor for depression in girls, especially those with high levels of social media use. Completion of the proposed aims is an important step towards identifying potentially modifiable behaviors that confer risk for depression-related outcomes in the context of social media use, and informing future prevention and intervention for depression in adolescent girls.

PI_NAMEs: MCNEILLY, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adolescent Development;Affective;Age;Behavior;Behavioral;boys;Brain;child depression;Clinical;Communication;Data;Decision Making;Depressive disorder;depressive symptoms;Development;disability;Disclosure;early adolescence;Elements;experience;Fellowship;Female Adolescents;Functional Magnetic Resonance Imaging;Funding;Future;girls;Goals;indexing;innovation;Intervention;intimate behavior;Knowledge;Learning;Link;longitudinal analysis;longitudinal, prospective study;Measures;media use;Medial;Mental Depression;Mental disorders;Mental Health;Methods;modifiable behavior;modifiable risk;National Research Service Awards;neural;neurobehavioral;neurobehavioral test;neuroimaging;Oregon;Outcome;Pattern;peer;Population;predictive modeling;Prefrontal Cortex;Prevalence;Prevention;prospective;Published Comment;Research;Research Infrastructure;Rewards;Risk;Risk Factors;Science;Scientist;Self Disclosure;social;social media;Societies;Surgeon;Testing;Time;Training;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Intimate self-disclosure and social media use in adolescent girls: Predicting depression from brain and behavior


NIH_SPENDING_CATS: Cancer;Genetics;Prevention

PI_NAMEs: CRAIK, CHARLES SCOTT (contact)

PROJECT_TERMS: anti-cancer research;Back;Basic Science;Behavior;bench to bedside;Big Data Methods;Biological Markers;Biology;Cancer Center Support Grant;Chemicals;Chromosome Mapping;Clinical;clinical application;collaborative environment;community engagement;Computers;Diagnostic;Discipline;Dissemination and Implementation;Drug resistance;Drug Targeting;Early Diagnosis;Environment;Epidemiologist;Epigenetic Process;Foundations;Genetic;Germ Lines;Goals;imaging detection;Incidence;KRAS2 gene;Malignant Neoplasms;member;Mission;molecular oncology;mutant;Mutation;new therapeutic target;novel;novel therapeutics;oncology program;Pathway interactions;Phenotype;Population Heterogeneity;Predisposition;Preventive;programs;Research;Research Personnel;Resistance development;Resources;Risk;Risk Factors;Scientist;Signal Pathway;Systems Biology;Technology;Therapeutic;Tissues;tool;Training and Education;Translating;Translations;treatment response;tumor;Tumor Biology;Work

PROJECT_TITLE: Molecular Oncology Program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Chronic alcohol exposure produces profound changes in neurotransmission. This project investigates the relationship between chronic alcohol exposure, brain cholesterol metabolism and glutamate transmission. Completion of this project may provide new molecular targets for potential therapeutic intervention of alcohol use disorder.

PI_NAMEs: CHEN, RONG  (contact);MCCOOL, BRIAN A

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Ablation;Acceleration;Affect;alcohol abuse therapy;alcohol behavior;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Animals;anxiety-like behavior;Attenuated;Behavior;behavior measurement;Behavioral;Binding;Brain;Brain region;Cholesterol;Cholesterol Homeostasis;Chronic;CRISPR/Cas technology;Data;Density Gradient Centrifugation;Dependence;Electrophysiology (science);Enzymes;Ethanol;Ethanol dependence;Excision;extracellular;Genes;Glutamates;GTP-Binding Proteins;Impairment;improved;innovation;Knowledge;Learning;Lentivirus Vector;Measures;Mediating;Membrane;metabotropic glutamate receptor 2;Microdialysis;Molecular;Molecular Target;Monitor;Mood Disorders;National Institute on Alcohol Abuse and Alcoholism;neural;Neurobiology;neuronal excitability;Neurons;neurophysiology;neurotransmission;novel;Oxidoreductase;Patients;postsynaptic;Prefrontal Cortex;presynaptic;prevent;protein activation;Rattus;Reporting;Research;Rodent Model;segregation;Signal Transduction;Strategic Planning;Sucrose;Synapses;Testing;Therapeutic Intervention;Tissues;tool;transmission process

PROJECT_TITLE: Ethanol and mGluR2 signaling

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nanotechnology;Substance Misuse

ORG_CITY: Mountain View

ORG_NAME: REJUVENATION TECHNOLOGIES, INC.

PHR: Narrative Alcoholic hepatitis (AH) is an acute form of alcoholic liver disease (ALD) with high short-term mortality, with over 450,000 hospital admissions per year and a 40–50% mortality rate (for severe AH) at 1 month from presentation. Chronic liver injury from excessive alcohol consumption leads to telomere shortening in the liver, and there is strong evidence that telomere extension may improve AH patient survival. This project will advance Rejuvenation Technologies’ breakthrough treatment for AH, comprised of telomerase mRNA that extends telomeres transiently, the same mechanism used by stem cells, and a lipid nanoparticle vehicle that delivers the telomerase mRNA to the liver with high efficiency and low toxicity.

PI_NAMEs: RAMUNAS, JOHN  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acute;Alcohol consumption;Alcoholic Hepatitis;Alcoholic liver damage;Alcoholic Liver Diseases;Animals;Biodistribution;Biological;brief intervention;Cell division;Cells;Chromosomes;Chronic;chronic liver disease;chronic liver injury;Cirrhosis;Clinical;Clinical Treatment;Clinical Trials;COVID-19 pandemic;Data;Death Rate;design;disease model;Disease Progression;DNA;DNA Damage;Dose;Drug Kinetics;Epidemiology;Etiology;Exhibits;Fibrosis;first-in-human;Grant;Health;Heavy Drinking;Hepatic Stellate Cell;Hepatocyte;Hospitalization;Hospitals;improved;infection risk;Inflammation;Intravenous;invention;Legal patent;Length;lipid nanoparticle;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;loss of function;lung health;manufacture;manufacturing scale-up;Medical;meetings;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA delivery;Mus;Mutation;Natural regeneration;nonhuman primate;Oncogenes;Pathologic;Patients;Pharmaceutical Preparations;Pharmacology;Phase;Play;pre-Investigational New Drug meeting;Primates;Prognosis;Proteins;Recovery;Regenerative capacity;Rejuvenation;response;Risk;Role;senescence;senescence associated secretory phenotype;Severities;Small Business Innovation Research Grant;stem cells;Steroids;Survival Rate;T cell infiltration;Technology;Technology Transfer;Telomerase;telomere;Telomere Shortening;Testing;Therapeutic Effect;Thioacetamide;Toxic effect;Toxicokinetics;Toxicology;Transfection;Translating;treatment effect;Universities

PROJECT_TITLE: TERT mRNA lipid nanoparticles to extend telomeres to treat alcoholic hepatitis


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: CHANG, SUSAN M (contact)

PROJECT_TERMS: Affect;Back;Biology;biomarker identification;blood-brain barrier disruption;Brain;Brain Neoplasms;Cancer Center Support Grant;Caring;Characteristics;Clinical;clinical application;Clinical Trials;Collaborations;collaborative environment;community engagement;Databases;Development;Developmental Biology;Disease;Dissemination and Implementation;Drug Delivery Systems;effective therapy;Ensure;Epidemiology;Evaluation;Evolution;Genetic;Genomics;Glioblastoma;Glioma;Goals;Government Agencies;Growth;health determinants;Image;imaging probe;Immunotherapy;improved;Industry;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;interest;International;Leadership;Malignant neoplasm of brain;Malignant Neoplasms;member;meningioma;metabolic imaging;Molecular;neuroimaging;neuroimmunology;Neurologic Oncology;Neurons;Neurosciences;novel therapeutics;oncology program;Outcome;Patients;personalized approach;Phase;Positioning Attribute;precision medicine;Prediction of Response to Therapy;Predictive Factor;Prognostic Factor;programs;Progression-Free Survivals;Quality of life;Research;Research Personnel;Resources;response;Risk Assessment;Role;Science;Scientist;Signal Transduction;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Training and Education;Translating;Translational Research;Translations;tumor;Tumor Biology;Tumor Markers;tumor microenvironment;ultrasound;Work

PROJECT_TITLE: Neurologic Oncology Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Chronic alcohol exposure causes cognitive deficits, which are associated with increased relapse probability and continued misuse. I hypothesize that chronic alcohol exposure produces cognitive deficits through altering activity and function of the nucleus reuniens of the thalamus and that normalizing its activity will attenuate cognitive dysfunction. Using a multimodal experimental approach, I will characterize the impact of chronic ethanol exposure on nucleus reuniens physiology and demonstrate how it impacts cognitive function.

PI_NAMEs: LINDQUIST, KATHY  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adult;Age;alcohol abstinence;alcohol abuse therapy;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Animal Model;Attention;Attenuated;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Brain region;Cells;Chronic;chronic alcohol ingestion;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive process;cohort;Data;Dependence;Development;drinking;Drug usage;Electrophysiology (science);Ethanol;executive function;Exhibits;experimental study;Female;Fetal Alcohol Syndrome;Fiber;flexibility;Fright;functional adaptation;Future;Goals;Health;Heavy Drinking;Hippocampus;Hyperactivity;Impaired cognition;improved;in vivo;Inhalation;Knowledge;Lead;Learning;maladaptive behavior;male;Measures;Medial;Mediating;Memory;Midline Thalamic Nuclei;Modeling;mouse model;multimodality;Mus;negative affect;Neurons;neurotransmission;new therapeutic target;optogenetics;patch clamp;Pattern;Performance;Persons;Photometry;Physiology;Play;Predisposition;Prefrontal Cortex;Probability;Relapse;Research;Research Proposals;Reuniens Thalamic Nucleus;Role;sex;Sex Differences;Short-Term Memory;Slice;Stress;Surveys;Synaptic Transmission;Testing;Thalamic structure;Tracer;Training;vapor;Withdrawal

PROJECT_TITLE: Nucleus reuniens, chronic ethanol and cognitive deficits


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

PHR: PROJECT NARRATIVE Conceptual models of childhood adversity propose that specific features of adversity significantly increase risk for mental health problems throughout the lifespan likely through mechanisms such as changes in biological development. This project aims to leverage multivariate approaches with a longitudinal sample to identify the respective benefits of each conceptual model in relation to adolescent neural development and mental health trajectories, and will explore how positive childhood experiences influence such relationships. The knowledge gained from this project will contribute to scientific understanding of linkages between exogenous exposures and development, and will advance methodological approaches to be coextensive with the complexity inherent to measuring and operationalizing childhood experiences.

PI_NAMEs: BARRETT, ANN-MARIE  (contact)

PROJECT_TERMS: Adolescence;Adolescent;adolescent brain development;Adolescent Development;adverse childhood events;Adverse event;Age;age related;Area;Behavior;biological development;Biology;Brain;brain based;brain health;Buffers;career;Child;Childhood;childhood adversity;Chronic stress;Clinical;Communication;Computational Technique;Consultations;Data;Data Set;deprivation;Development;Dimensions;Dose;early life adversity;experience;Female Adolescents;flexibility;Goals;Health;Individual;Intervention;Knowledge;Life Experience;life span;Link;longitudinal analysis;Longitudinal Studies;Measurement;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;Methods;Modeling;neural;Neurobiology;neurodevelopment;neuroimaging;neuromechanism;neurophysiology;Neurosciences;Oregon;Outcome;Pathway interactions;Pattern;Persons;Process;Psychopathology;Reporting;Reproducibility;Research Personnel;resilience factor;response;Risk;Role;Sampling;Science;Standardization;Stress;Structure;Sum;Symptoms;Techniques;Thinness;Time;Training;Training Support;translational applications;translational neuroscience;Undifferentiated;United States;Universities

PROJECT_TITLE: Conceptual Models of Childhood Adversity: Multivariate and Neural Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-H(20)L]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The escalating rates of alcohol use among vulnerable youth populations necessitate a thorough understanding of how environmental factors shape risky decision-making, especially regarding alcohol use. This study proposes a novel multivariate approach that uses longitudinal data from the ABCD Study to calculate a polyexposure risk score and determine the role of inhibitory control in the risk for alcohol use onset in youth ages 10-14. The findings are expected to provide critical insights into the complex multidimensional features of youth at greater risk for early onset of alcohol use, and inform effective risk-mitigating strategies to reduce the prevalence of alcohol use among vulnerable youth populations.

PI_NAMEs: ADAMS, FAITH  (contact)

PROJECT_TERMS: 10 year old;15 year old;addiction;Address;Adolescence;Adolescent;Affect;Age;alcohol behavior;Alcohol consumption;alcohol misuse;alcohol outlet density;alcohol risk;alcohol use disorder;alcohol use initiation;Alcoholism;Anterior;Behavioral;Benchmarking;Big Data;big-data science;binge drinking;Bioinformatics;biopsychosocial factor;Brain;career;Child Abuse and Neglect;cingulate cortex;Clinical;clinical application;clinically actionable;cognitive development;cohort;Cohort Studies;Complex;computer science;Data;Data Reporting;Data Science;Decision Making;density;Development;Diabetes Mellitus;Diet;Dimensions;distilled alcoholic beverage;drinking;early alcohol use;effective intervention;Environment;Environmental Exposure;Environmental Risk Factor;Equity;ethnoracial;Etiology;European;European ancestry;Exclusion;experience;Family;Family history of;Functional Magnetic Resonance Imaging;Future;Genetic;genetic risk factor;Genetic study;genetic variant;Genome;genome wide association study;Goals;High Performance Computing;Home;Individual;Inferior frontal gyrus;insight;Institution;Instruction;Intervention;Life Style;Link;Mediating;Medical;medical schools;Mentors;Mission;motor control;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;neural;neurobehavioral;Neurobiology;neuroimaging;non-genetic;novel;Outcome;parental monitoring;Participant;Patient Self-Report;peer;Performance;Play;Policies;Pollution;polygenic risk score;Population;Poverty;Predisposition;Prefrontal Cortex;Prevalence;prevent;Prevention;prospective;Public Health;racial bias;Reaction Time;Research;Resources;response;Risk;Risk Factors;risk mitigation;Role;Sampling;Schools;Shapes;Siblings;Signal Transduction;skills;social;Social Desirability;social stigma;socioeconomics;substance use;Techniques;Training;Training Programs;underage drinking;young adult;Youth

PROJECT_TITLE: Data-Driven Exploration of Exposomic Influences on the Onset of Alcohol Use During Adolescence


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Hyperadrenergic autonomic crises are episodes of drastic and acute increases in blood pressure and heart rate, accompanied by unremitting vomiting, retching, and are the most frequent and severe manifestations of a rare genetic disease - familial dysautonomia (FD). Hyperadrenergic autonomic crises result from improper develop- ment and function of the autonomic nervous system and are treated primarily using non-pharmacologic measures and at-home medications that carry severe side effects and don’t prevent secondary complications. In this study, we will test a new approach to resolving the autonomic crises in patients with FD that combines an easily deliverable and effective medication, sublingual dexmedetomidine film, along with non-pharmacological assistance through telemedicine and a wearable device that continuously records vital signs, to provide data to be applied towards the development of effective, at-home strategies for autonomic crises resolution and preven- tion.

PI_NAMEs: GONZALEZ-DUARTE BRISENO, MARIA ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients with Familial Dysautonomia


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: SWEET-CORDERO, ERIC ALEJANDRO (contact)

PROJECT_TERMS: Advanced Development;Basic Science;Biological Markers;Brain Neoplasms;Cancer Center Support Grant;Cancer Patient;Cell Line;Cells;Characteristics;Child;Childhood;Childhood Leukemia;Childhood Lymphoma;Clinic;Clinical;clinical phenotype;Clinical Research;Clinical Trials;clinically relevant;community engagement;Computerized Medical Record;Correlative Study;Data;Development;Developmental Biology;early phase clinical trial;embryo tissue;Evolution;Failure;Genetic;Genome;genome sequencing;Goals;Growth;Hematologic Neoplasms;Human Development;improved outcome;induced pluripotent stem cell;innovation;innovative technologies;insight;Knowledge;Leadership;leukemia;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;meetings;member;Mutation;neuro-oncology;Neuroblastoma;new therapeutic target;novel therapeutic intervention;novel therapeutics;Osteosarcoma;Pathway interactions;patient derived xenograft model;Pattern;Pediatric Neoplasm;Pediatric Oncology Group;pediatric patients;Plexiform Neurofibroma;pre-clinical;programs;Research;Research Personnel;Resources;Sarcoma;Signal Pathway;Solid Neoplasm;stem;targeted treatment;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;Tissue Microarray;Toxic effect;Training and Education;transcriptome sequencing;Translating;Translational Research;tumor;Tumor Bank;whole genome;Work

PROJECT_TITLE: Pediatric Malignancies Program


NIH_SPENDING_CATS: Aging;Cancer;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: FENG, FELIX YI-CHUNG (contact)

PROJECT_TERMS: Address;advanced disease;Back;Basic Science;Biological;Biological Markers;biomarker development;biomarker validation;Cancer Center Support Grant;Cancer Patient;Catchment Area;Characteristics;Clinical;clinical application;clinical heterogeneity;clinical translation;community engagement;Disease;Disease Management;Disease Progression;Disparity;Early Diagnosis;effective therapy;Foundations;Goals;high risk;imaging approach;improved outcome;Intervention;Knowledge;Malignant neoplasm of prostate;men;Mission;model development;Modeling;Molecular;Morbidity - disease rate;mortality;novel therapeutics;Outcome;outcome prediction;overtreatment;Patients;Population;Population Sciences;predictive marker;Prognostic Marker;prognostic model;programs;Research;Residual Neoplasm;Risk;Science;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Training and Education;Translational Research;Translations;tumor;Tumor Biology

PROJECT_TITLE: Prostate Cancer Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cancer is the second leading cause of death in the United States. Many cancers show a difference in incidence or outcomes between males and females. This proposal explores how rearrangements involving the X- chromosome can lead sex-specific differences in cancer pathogenesis and unveil sex-specific vulnerabilities.

PI_NAMEs: VISWANATHAN, SRINIVAS RAGHAVAN (contact);ZHANG, CHENG-ZHONG

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Automobile Driving;autosome;Bioinformatics;cancer genomics;cancer initiation;cancer type;Carcinogen exposure;Cause of Death;Cells;Chromosomal Stability;Chromosome abnormality;Chromosomes;cohort;CRISPR screen;CRISPR/Cas technology;Dependence;Development;Disproportionately impacts women;Environmental Risk Factor;Epigenetic Process;Equilibrium;Experimental Models;Female;Future;Gene Expression;Gene Silencing;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Predisposition to Disease;Genetic Transcription;genome-wide;Genomic approach;genomic data;Genomics;Haplotypes;health care availability;Homologous Gene;Hormonal;Incidence;innovation;Lead;Life Style;male;Malignant Neoplasms;Methods;Modeling;Mutation;non-genetic;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;Pathogenesis;Phenotype;Play;Process;Public Health;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Risk;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;Shapes;Somatic Cell;System;Testing;TFE3 gene;tumor;tumor initiation;tumor progression;United States;Untranslated RNA;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Probing the role of somatic X-chromosome alterations in shaping cancer sex differences

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Nutrition;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Healthy tongue function is vital for human chewing, swallowing and speaking, and loss of tongue function due to stroke, degenerative diseases and surgery results in significant health problems, including, malnutrition, pneumonia, and difficulty swallowing and speaking. This project will use natural feeding behaviors in nonhuman primates to elicit a wide range of tongue movements and associated muscle and brain activity during chewing and swallowing, develop and test biomechanical models of how tongue movements are produced and how the brain controls those movements. These data will inform strategies for rehabilitation of chewing and swallowing in patients through exercise, non-invasive brain stimulation, lingual prostheses and brain machine interfaces.

PI_NAMEs: HATSOPOULOS, NICHOLAS G;ROSS, CALLUM F (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Behavior;Behavioral;Bilateral;biomechanical model;biomechanical test;Biomechanics;Brain;brain control;brain machine interface;Data;Degenerative Disorder;Deglutition;Deglutition Disorders;Development;Diet Modification;drinking;Dysarthria;Electrodes;Elements;Exercise;exercise rehabilitation;feeding;Feeding behaviors;Food;grasp;Health;Human;human mortality;Hydromorphone;Implant;innovation;insight;Intramuscular;Jaw;Joints;kinematics;Left;Link;Liquid substance;Macaca;Macaca mulatta;Malignant Neoplasms;Malnutrition;Mastication;Mechanics;meetings;Morbidity - disease rate;motor control;Motor Cortex;Movement;Muscle;Musculoskeletal System;neural;Neurons;neuroprosthesis;Neurosciences;nonhuman primate;noninvasive brain stimulation;Operative Surgical Procedures;oral behavior;Oral cavity;Organ;orofacial;Patients;Pneumonia;Population;pressure;Property;Prosthesis;Quality of life;rehabilitation strategy;Research;Research Project Summaries;Role;sensory cortex;Shapes;Signal Transduction;Solid;Speech;Stroke;Study models;System;Techniques;Testing;Tongue;tongue biomechanics;tongue root;Training;Variant

PROJECT_TITLE: Cortical control and biomechanics of tongue movement

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SAN FRANCISCO

PI_NAMEs: RHOADS, KIM FELDER (contact)

PROJECT_TERMS: Address;Age;Applications Grants;Area;Automobile Driving;Awareness;Breast;Cancer Burden;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer invasiveness;cancer survival;Catchment Area;Characteristics;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Colorectal;Communities;community academic partnership;community advisory board;community collaboration;community engagement;Community Health;Community Outreach;community partners;community partnership;community research;Country;Data;data management;demographics;Development;Dimensions;Disparity;Dissemination and Implementation;Ensure;Environment;Equity;Ethnic Origin;experience;Faculty;Funding;Gender;Geographic Distribution;Goals;health determinants;Health Educators;improved;Individual;Institution;Intervention;Knowledge;Leadership;life span;Lung;Lymphoma;Malignant Neoplasms;Maps;Measures;Mission;Nature;nutrition;Outcome;outreach;Physical activity;Policies;Population;Population Heterogeneity;Prostate;Race;Research;Research Activity;Research Personnel;Research Priority;Research Proposals;Resources;sociodemographics;Tobacco use;Toxic Environmental Substances;Translations;Work

PROJECT_TITLE: Community Outreach and Engagement