ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE The Eph cell surface receptors comprise a large family with 14 members; these receptors play important roles in physiological and pathological processes by assembling into signaling complexes that control cell behavior. This proposal will study the unique features of heterogeneous complexes formed by the EphA2 receptor together with other Eph receptors, which we hypothesize have distinctive signaling properties compared to homogeneous EphA2 complexes. We anticipate that our studies will ultimately inform the design of new therapies targeting mixed EphA2-Eph signaling platforms.

PI_NAMEs: HRISTOVA, KALINA ;PASQUALE, ELENA B (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affect;angiogenesis;arm;Biological;Biological Assay;Biological Process;biophysical analysis;biophysical techniques;Biophysics;C-terminal;cancer cell;cell behavior;Cell Line;Cell membrane;cell motility;Cell Surface Receptors;Cells;Complex;design;dimer;Disease;Drug resistance;Engineering;Ensure;Eph Family Receptors;EphA Receptors;EphA2 Receptor;Ephrin B Receptor;ERBB2 gene;ERBB3 gene;Family;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Future;Heterodimerization;Homo;Inflammation;inhibitor;innovation;insight;Invaded;Knowledge;Ligand Binding Domain;Ligands;Link;Lysine;Malignant Neoplasms;Measures;Mediating;member;monomer;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;Pathogenicity;Pathologic;Pathologic Processes;Peptides;Phosphorylation;Phosphotransferases;Physiological;Physiological Processes;Play;Process;Property;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;receptor;Receptor Protein-Tyrosine Kinases;recruit;Regulation;response;Role;Serine;Side;Signal Pathway;Signal Transduction;targeted treatment;Therapeutic;therapy design;Time;tool;Tyrosine;Work;β-Alanine

PROJECT_TITLE: Eph Receptor Heterointeractions in Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The onset and progression of Type 2 Diabetes (T2D) stems from the complex interaction between lifestyle, nutrition, and genetics. To better understand how the interaction between diet and genetics contributes to T2D, we are conducting whole-genome studies in the fruit fly (Drosophila melanogaster), which like humans, develops T2D when fed a high-sugar diet. Our studies in the fly will identify genes that normally prevent T2D upon chronic sugar consumption.

PI_NAMEs: D'ALESSANDRO, ANGELO ;MARYGOLD, STEVEN ;PERRIMON, NORBERT ;TENNESSEN, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;Adult women;Animal Model;Animals;Biochemical Pathway;Bioinformatics;bioinformatics resource;Body System;Brain;Cell Physiology;cell type;Cells;Chronic;Collection;Communities;Complex;computing resources;Consumption;Data;Data Set;Databases;Diabetes Mellitus;diabetic;Diet;dietary;disease model;Drosophila genus;Drosophila melanogaster;Endocrine;Enzymes;Fasting;fly;FlyBase;gene function;Genes;Genetic;Genetic Models;genetic resource;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide analysis;Glucose;Glycogen;Goals;Heart;Human;Hyperglycemia;improved;in vivo;in vivo Model;Individual;Insulin;Insulin deficiency;Insulin Resistance;insulin sensitivity;interoperability;Intestines;Kidney;knowledgebase;Life Style;Link;Liver;male;Manuals;Measures;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;Modeling;multiple omics;Muscle;new technology;Nomenclature;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrient absorption;nutrition;Obesity;Organ;Outcome;Pancreas;pancreatic juice;Pathway interactions;Peripheral;Phenotype;Population;predictive modeling;prevent;programs;Reporting;Research;response;RNA Interference;Role;Sampling;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;small molecule;stem;Stress;Structure of beta Cell of islet;Study models;sugar;System;Tissues;tool;Toxic effect;transcription factor;Triglycerides;Update;Vertebrates;whole genome

PROJECT_TITLE: Investigating metabolic responses to high sugar diets and the onset of diabetic phenotypes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Brain bleeding from aneurysm rupture is a life-threatening occurrence in 30,000 people annually in the US, and while a third have good outcome, another third survives with disability. Delayed strokes related to the bleed are a common leading cause of this disability that occurs while patients are hospitalized, but the onset can be subtle and found only in retrospect. We aim to turn an artificial intelligence model that accurately assesses risk of this secondary brain injury into a monitor, capable of implementation in any intensive care unit to maximize opportunities to intervene and improve disability.

PI_NAMEs: PARK, SOOJIN  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Age;Age of Onset;aggressive therapy;Algorithms;American;Aneurysmal Subarachnoid Hemorrhages;Architecture;Artificial Intelligence;artificial intelligence model;authority;Big Data to Knowledge;Biological Availability;Brain;Brain Injuries;Cerebral Ischemia;Classification;Clinical;clinical decision support;clinical diagnosis;clinical practice;clinical risk;Clinical Trials;Code;Collaborations;Communities;computer human interaction;Custom;Data;Decision Making;Delirium;design;Devices;Diagnosis;diagnostic strategy;Diagnostic tests;disability;effectiveness study;effectiveness testing;Ensure;Ethics;Evaluation;experimental study;Fast Healthcare Interoperability Resources;Future;Generations;health information technology;Healthcare;Heart;Hemorrhage;Hospitalization;Hospitals;Hour;improved;individual patient;Inflammatory;Informatics;innovation;Institution;Intensive Care Units;interoperability;Intervention;iterative design;Laboratories;Life;loss of function;machine learning model;Methodology;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;Nature;Nervous System Trauma;new technology;novel;Observational Study;open source;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Performance;Persons;Physiological;Physiology;Play;predictive modeling;Probability;Procedures;Production;Productivity;prospective;prototype;real time model;Research Design;Resources;Risk;Risk Assessment;Ruptured Aneurysm;Safety;Seizures;Signal Transduction;Signs and Symptoms;simulation;Site;skills;Specialist;Stroke;Stroke prevention;stroke symptom;Subarachnoid Hemorrhage;support tools;Symptoms;Syndrome;Technology;Testing;Time;tool;Translating;Translations;Trust;United States National Institutes of Health;Update;user centered design;Validation;Virginia;World Health Organization

PROJECT_TITLE: ContinuOuS Monitoring Tool for Delayed Cerebral IsChemia (COSMIC)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Palliative Care;Racial and Ethnic Minority Health Research

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The disproportionate rise in nursing home use among Black and Latino persons living with dementia (PLWD) reflects the inadequacy of existing programs and policies to support aging in place for these most at-risk populations. The goals of this study are to 1) identify the unmet needs that drive Black and Latino PLWD to experience potentially avoidable NH placements at greater rates than their White counterparts using an exploratory sequential mixed methods research design and 2) translate preliminary findings onto the public agenda as a policy issue. This work will inform intervention and policy development aimed at filling gaps in needs significant to Black and Latino PLWD’s ability to remain in the community for their long-term care as long as possible.

PI_NAMEs: TRAVERS, JASMINE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: access disparities;Address;Aging;aging in place;Alzheimer's disease related dementia;Assessment tool;Automobile Driving;Black Populations;Black race;care delivery;career;caregiving;Caring;Case Manager;college;Communities;community living;community setting;cost;COVID-19;Data;Dementia;design;Discipline of Nursing;Disparate;Disparity;disparity elimination;disparity reduction;Doctor of Philosophy;Environment;Ethnic Origin;Evaluation;evidence base;experience;Face;Family;feasibility testing;Future;Geriatric Nursing;Gerontology;Goals;Health Care Costs;Health Policy;Healthcare Systems;high risk;Home;Hospitals;Impaired cognition;Income;infection risk;informant;innovation;instrument;Interview;Jasminum;Knowledge;Latino;Latino Population;leadership development;Living Wills;Long-Term Care;Medical;Mentors;method development;Methods;Minority;Morbidity - disease rate;mortality;Needs Assessment;New York;Nurse Practitioners;Nursing Homes;older adult;Older Population;person centered;Persons;pilot test;Policies;Policy Developments;Policy Maker;policy recommendation;Population;Populations at Risk;Positioning Attribute;preference;Prevalence;prevent;professor;programs;Psychometrics;Quality of Care;Race;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Sampling;Services;Structure;Support System;Surveys;Techniques;Testing;therapy development;Training;Translating;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Identifying Unmet Needs Driving Disproportionate and Avoidable Nursing Home Placements among Black and Latino Persons Living With Dementia


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Respiratory infections such as respiratory melioidosis cause significant mortality. The objective of this project is to develop a comprehensive understanding of the many different biological changes that occur during this severe infection. The knowledge gained from this proposal may ultimately help to reduce the burden of respiratory infections and improve public health.

PI_NAMEs: GHARIB, SINA A;WEST, TIMOTHY EOIN (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Admission activity;Animal Model;Antibiotic Therapy;Aromatherapy;Bacteremia;Bioinformatics;Biological;Bioterrorism;Blood;Burkholderia pseudomallei;case control;Cells;Cessation of life;Classification;clinically relevant;comparative;Data;Disease;Disease Outbreaks;disease phenotype;E. coli bacteremia;Environment;Experimental Models;Failure;Genetic Transcription;Goals;Heterogeneity;Hospitalization;Host Defense;Host Defense Mechanism;Hour;Human;human disease;Immune response;improved;Infection;Ingestion;Inhalation;insight;Investigation;Klebsiella pneumoniae;Knowledge;Leukocytes;Lung;lung failure;Melioidosis;metabolome;metabolomics;Mississippi;mortality;mortality risk;mouse model;Multiomic Data;multiple omics;Mus;novel;Outcome;Overlapping Genes;pathogen;Pathway interactions;Patients;peripheral blood;Phenotype;Plasma;Pneumonia;programs;Prospective cohort;Proteomics;Public Health;recruit;Resolution;Resources;respiratory;Respiratory Tract Infections;Route;Sampling;Sepsis;Signal Transduction;single nucleus RNA-sequencing;Soil;Staphylococcus aureus;Structure of parenchyma of lung;success;targeted treatment;Thailand;Time;transcriptome;transcriptomics;United States

PROJECT_TITLE: Multi-omics of murine respiratory melioidosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Alcohol Use Disorder (AUD) is associated with deficits in cognitive control, including deficits in behavioral flexibility that contribute to goal-directed decision-making. These deficits contribute to poor daily function and are thought to underlie the lack of behavioral control observed in inflexible and compulsive alcohol use and relapse. Identifying how AUD alters cortical function is a critical step towards restoring cognitive function.

PI_NAMEs: GREMEL, CHRISTINA M. (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Address;Affect;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohols;Area;Behavior;Behavior Control;Behavioral;Calcium;Cell Physiology;cell type;Chronic;cognitive control;cognitive function;Corpus striatum structure;daily functioning;Data;Decision Making;Dependence;Dorsal;Ethanol;experimental study;flexibility;Functional disorder;Funding;Goals;Homologous Gene;Hyperactivity;Impulsivity;in vivo;Interneurons;Lateral;Medial;Monitor;Motor;Motor Cortex;Motor output;Mus;Nature;neuronal excitability;Neurons;novel;Output;Pathway interactions;Physiology;Population;preclinical study;Primates;Process;Psychopathology;recruit;Rodent;Secondary to;Self Administration;Series;Slice;Testing;transmission process;Withdrawal;Work

PROJECT_TITLE: Dependence induced dysfunction of decision-making circuits

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: A major challenge of genomic medicine is to convert the large catalogue of disease- associated variants and gene expression states into actionable therapeutic targets. The proposed aims will build the foundational knowledge base and tools for controlling gene expression in human cells by delivering synthetic constructs that trigger epigenetic memory of gene expression states. These aims will pave the way for future epigenetic therapeutic strategies that open large portions of the human genome to direct therapeutic targeting with high precision for disease pathophysiology.

PI_NAMEs: HSIUNG, CHRIS CHUAN SHU (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Area;Bypass;career;career development;Catalogs;Cell division;cell type;Cells;cellular transduction;Chromatin;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Complex;constitutive expression;cost effective;Disease;DNA Library;DNA Sequence;DNMT3a;Engineering;Enhancers;epigenetic memory;Epigenetic Process;epigenetic silencing;epigenomics;Exhibits;frontier;Functional disorder;functional genomics;Future;Gene Expression;Gene Silencing;gene-targeted therapy;Genes;genetic regulatory protein;Genetic Transcription;Genome;genomic locus;Genomic medicine;Genomics;Goals;Guide RNA;Heritability;Human;Human Genome;immunogenicity;improved;Induced pluripotent stem cell derived neurons;innovation;insight;interest;K562 Cells;knowledge base;Libraries;Memory;Mentors;Messenger RNA;Methods;Mitotic;Molecular;Monitor;N Domain;Neurodegenerative Disorders;neurogenetics;nuclease;Physiologic pulse;promoter;protein complex;Proteins;recruit;Regulation;Regulatory Element;Reporting;Repressed Memory;Repression;Research;Research Personnel;Resources;Ribonucleoproteins;Risk;Running;Sampling;Signal Transduction;Site;Specificity;success;synthetic biology;synthetic construct;targeted treatment;tau Proteins;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;tool;Training;transcriptomics;Variant

PROJECT_TITLE: High-throughput engineering of combinatorial chromatin signals and epigenetic cellular memory

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Amyloids are fibrous protein assemblies that play a critical role in the progression of numerous severe human diseases including Alzheimer’s, Parkinson’s, and transthyretin cardiac amyloidosis. My research goals are to delineate the physiological pathways and mechanisms that healthy cells have evolved to regulate formation, function, and reversibility of amyloids. Knowledge gained from these studies will lead to important advances in our understanding of the causes of neurodegenerative diseases and will eventually lead to therapeutic opportunities.

PI_NAMEs: BERCHOWITZ, LUKE E (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Elucidating the regulation and function of amyloid-like assemblies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE Aging and aging-related vascular diseases are associated with decreased cellular functions. The proposed studies seek to investigate how aging and decreased blood flow to the brain affect the brain vasculature of mice. Specifically, we aim to explore the associations among aging, vascular structure, function, decreased brain perfusion, and vascular mitochondria.

PI_NAMEs: RUTKAI-GREEN, IBOLYA  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Affect;Aging;aging brain;aging related;Alzheimer's Disease;Arteries;Autophagocytosis;Bilateral;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood flow;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Mapping;brain parenchyma;Cardiovascular Diseases;Cardiovascular Pathology;Carotid Stenosis;Cell Physiology;Cells;Cephalic;cerebral hypoperfusion;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chimeric Proteins;Common carotid artery;Complement;Complex;Data;Dementia;density;Deterioration;Development;Disease;Elderly;Endothelial Cells;Endothelium;Equilibrium;Exposure to;Female;functional decline;Functional disorder;Goals;hallmarks of aging;Health;Heart;Hyperemia;hypoperfusion;Immunofluorescence Immunologic;Impaired cognition;improved;in vivo;Lead;Link;Long term disability;male;Maps;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morphology;mortality;Mus;Nature;Neurodegenerative Disorders;neurovascular coupling;old mice;Organ;Pathology;Peptides;Perfusion;Process;Production;protein expression;Proteins;Proteome;Proteomics;Quality Control;Reactive Oxygen Species;reconstruction;Rejuvenation;Research;respiratory;restoration;Risk Factors;Role;senescence;sham surgery;Skeletal Muscle;Slice;Structure;Surface;Testing;Therapeutic;Time;Tissues;two photon microscopy;vascular bed;Vascular Diseases;Vascular Endothelium;Vascularization;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Understanding the role of the cerebral microvasculature in brain aging

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Anemia and dysregulated iron homeostasis is a common complication of inflammatory bowel disease (IBD). However, the regulation and impact of intestinal iron homeostasis in IBD is unknown. The focus of this proposal is to better understand how intestinal iron is regulated in intestinal inflammation, and whether modulating iron homeostasis might be therapeutic in IBD.

PI_NAMEs: BESSMAN, NICHOLAS J. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acute;Address;Affect;Anatomy;Anemia;Bacteria;Biological Markers;Biology;Cell Physiology;cell type;Cells;Cellular biology;Childhood;Chronic;Colitis;Complication;Crohn's disease;Data;Dendritic Cells;Diabetes Mellitus;Dietary Iron;Disease;experience;extracellular;Genetic;Growth;gut inflammation;healing;Health;Helicobacter hepaticus;hepcidin;Homeostasis;Hormones;Human;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Interleukin-10;Intestines;Iron;iron supplementation;Knowledge;Link;Liver Cirrhosis;Macrophage;Malignant neoplasm of liver;Mammals;Mediating;metal transporting protein 1;Microbe;microbiota;mouse model;Mucous Membrane;Mus;Myeloid Cells;neutrophil;novel;novel therapeutic intervention;Pathology;Patient risk;Patients;Pediatric Crohn's disease;Personal Satisfaction;Phagocytes;Predisposition;Publishing;Recycling;Refractory;Regulation;Research Proposals;Resistance;Role;Sampling;senescent cell;Small Intestines;Sodium Dextran Sulfate;standard care;T-Lymphocyte;Therapeutic;therapeutic target;tissue repair;Tissues;TNF gene;tool;uptake;Variant;Work

PROJECT_TITLE: The role of local iron homeostasis in inflammatory bowel disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: This project will contribute to public health by increase the recruitment, retention and success of community college students in obtaining a bachelor’s degree in the behavioral and biomedical sciences. The students in our training program will conduct research project contributing to the knowledge base in behavioral and biomedical sciences improving the health, life span, reducing illness and disability. This training program will increase the numbers, retention and success of students continuing on in the behavioral and biomedical science workforce at graduate students, research technicians, medical professionals, etc.

PI_NAMEs: LAYBOURN, PAUL JAMES (contact);SMITH, HEIDI R

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academic support;Articulation;Bachelor's Degree;Behavioral;Biological Sciences;bridge to the baccalaureate;career;Career Choice;cohort;Colorado;community college;Employment;Enrollment;Event;experience;Faculty;Financial Support;learning community;Mentors;Pathway interactions;Pattern;peer;Population;programs;recruit;Research;Research Training;scaffold;Scholarship;Scientist;Services;social;Students;summer research;Traineeship;Training Programs;transfer learning;transfer student;undergraduate research experience;Underrepresented Students;Universities;Wages

PROJECT_TITLE: Northern Colorado (NoCo) Bridges to the Baccalaureate Research Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Medicare is the primary health insurance for older adults (65+) living in the U.S., and eligible beneficiaries must choose between two different plan types: traditional Medicare and Medicare Advantage. The number of socioeconomically disadvantaged Black and Hispanic Medicare beneficiaries with Alzheimer’s disease and related dementia (ADRD) is growing, and they experience less preventive care and more adverse health events than their White counterparts. The proposed mixed methods study will examine racial/ethnic health disparities within and between the two Medicare plan options and explore the challenges of health plan decision-making among beneficiaries with ADRD to inform policies promoting more equitable health care and facilitating better health plan decision-making for socioeconomically disadvantaged Black and Hispanic Medicare beneficiaries with ADRD.

PI_NAMEs: MAHMOUDI, ELHAM  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academy;Adverse event;Advisory Committees;Alzheimer's disease related dementia;Back;beneficiary;Black race;care coordination;Caregivers;Caring;Characteristics;Communities;Complex;Continuity of Patient Care;County;Data;Data Analyses;Death Rate;Decision Making;design;Disadvantaged;Disparity;disparity reduction;econometrics;Eligibility Determination;eligible participant;Enrollment;Equitable healthcare;Equity;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Event;experience;Fee-for-Service Plans;Goals;Growth;Health;health care disparity;Health Insurance;health plan;Health Policy;Healthcare;high risk;Hispanic;Hospital Costs;hospital readmission;Hospitalization;innovation;Inpatients;insurance plan;Interview;Lead;Length of Stay;Maps;Measures;Medicare;Medicare claim;Medicine;Methods;Modeling;multidisciplinary;older adult;Older Population;patient population;payment;Policies;Positioning Attribute;Preventive care;Preventive service;Prospective Payment System;Qualifying;Quality of Care;Race;racial disparity;racial health disparity;racial minority;Reporting;Research;Risk;Sampling;Selection Bias;socioeconomic disadvantage;Structure;theories;treatment effect;Variant

PROJECT_TITLE: Racial/Ethnic Disparities in Health Care and Challenges in Insurance Plan Choices among Older People with Alzheimer’s Disease and Related Dementia: A Mixed Methods Study of Medicare Options


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Rehabilitation;Substance Misuse

ORG_CITY: PALO ALTO

ORG_NAME: AMYGDALA NEUROSCIENCES, INC.

PHR: PROJECT NARRATIVE Preclinical and available clinical data highlight the potential of selective, reversible ALDH2 inhibition as a promising validated target for safe treatment of alcohol use disorder (AUD). We have discovered ANS-858 that merits the completion of studies, enabled by this research grant, required for the application of an investigational new drug (IND) to the FDA.

PI_NAMEs: BLACKBURN, BRENT KEITH (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: acamprosate;Adult;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;American;Amygdaloid structure;Animal Model;Anxiety;attributable mortality;Behavior Therapy;Biological Availability;Centers for Disease Control and Prevention (U.S.);clinical candidate;Clinical Data;Cognitive Therapy;Counseling;craving;Development;Diagnosis;Disulfiram;Documentation;Dose;drinking;Drug Combinations;drug development;drug discovery;Drug Kinetics;economic cost;Eligibility Determination;Enzymes;European;experience;Failure;FDA approved;Grant;Health Services Accessibility;Hepatotoxicity;Human;Improve Access;inhibitor;Investigational Drugs;Investigational New Drug Application;Liver;member;Modernization;Naltrexone;Neurosciences;Oral;Outcome;Pamphlets;Patients;Penetration;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacological Treatment;Phase;Population;pre-clinical;Prodrugs;Program Development;Protocols documentation;Recovery;research clinical testing;Research Personnel;Research Project Grants;Research Support;Risk;risk mitigation;scale up;Small Business Innovation Research Grant;Societies;success;Therapeutic;Work

PROJECT_TITLE: Investigational New Drug (IND)-enabling and Early-Stage Development of Selective, Reversible, Orally Bioavailable ALDH2 inhibitor ANS-00858 to Treat Alcohol Use Disorder.


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Osteoporosis;Pediatric;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Plastin family of the actin cytoskeleton organizers contributes to the activation of immune cells, bone formation, cell division, migration, and adhesion as well as to shaping biological membranes essential for the absorbance of nutrients by the intestine, blood dialysis by kidneys, and audial perception by the inner ear. When disrupted or expressed ectopically, plastins contribute to the metastatic activity of cancer cells, autoimmune processes, congenital osteoporosis, syndrome of diaphragmatic hernia, and deafness. Our investigation will reveal fundamental molecular mechanisms underlying the activity of human plastins and will generate a strong and lasting impact on the fundamental understanding of the actin cytoskeleton leading to potential therapeutic interventions for cancers, familial osteoporosis, and autoimmune disorders.

PI_NAMEs: KUDRYASHOV, DMITRI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Adhesions;Age;Allosteric Regulation;Architecture;Attenuated;Autoimmune Diseases;Autoimmune Process;Binding;Biochemical;Biological;Blood;bone fragility;Bundling;Calcium;calponin;cancer cell;Cancer Intervention;cancer invasiveness;Cell Adhesion;Cell division;cell motility;Cell Physiology;Cells;cellular microvillus;Chronic Lymphocytic Leukemia;Communication;Communities;Complex;congenital hearing loss;Connective Tissue Diseases;coronin protein;Coupling;crosslink;Crosslinker;Cryo-electron tomography;Cryoelectron Microscopy;Cytokinesis;Cytoskeletal Modeling;Cytoskeleton;Data;deafness;Development;Diaphragmatic Hernia;Disease;Disseminated Malignant Neoplasm;Endocytosis;Epithelium;Event;F-Actin;Family;Fiber;Filopodia;Fimbrin;flexibility;Fluorescence;Focal Adhesions;Fostering;functional outcomes;Goals;Health;hearing impairment;Human;Human Activities;immune activation;Immune system;immunological synapse formation;improved;Individual;interest;Intestines;Investigation;Kidney;Labyrinth;LCP1 gene;Lead;Libraries;Link;Malignant Neoplasms;Maps;Mediating;member;Membrane;Microfilaments;Microscopy;migration;Modeling;Molecular;Molecular Conformation;molecular dynamics;mutant;Mutation;Nutrient;Osteogenesis;Osteoporosis;Pathology;Perception;Personal Satisfaction;plastin;Post-Translational Protein Processing;Process;Property;protein crosslink;Protein Isoforms;Proteins;Publishing;reconstruction;recruit;Recycling;Regulation;Renal dialysis;Research;Resolution;response;Role;Shapes;Signal Transduction;single molecule;Site;stem;Structural Models;Structure;Syndrome;Testing;Therapeutic;Therapeutic Intervention;Tissues;Translating;Tropomyosin;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular and cellular mechanisms of the actin cytoskeleton organization and function

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: NARRATIVE The proposed research will benefit NIH and have a direct impact on human health by improving our fundamental understanding of enzymes as biophysical machines. Better knowledge of long-range effects in protein structure and factors that enable high catalytic efficiency of enzymes will enable new approaches for making new and safer drugs as well as use of enzymes as biotherapeutics. The information generated on enzymes systems in this study have implications for several diseases including cancer, neuronal loss and pathogenicity.

PI_NAMEs: AGARWAL, PRATUL K (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Biliverdin reductase;biochemical model;Biological Response Modifier Therapy;biophysical model;Biophysical Process;Biophysics;Catalysis;Chemicals;Collaborations;Communities;Computing Methodologies;conformational conversion;Coupled;Coupling;Cyclophilin A;Data;Deposition;design;Development;Dihydrofolate Reductase;Disease;Distal;Drug Industry;Elements;Enabling Factors;Energy-Generating Resources;Environment;Enzyme Kinetics;enzyme model;enzyme structure;Enzymes;experimental study;Family;Health;Hereditary Disease;Human;human disease;improved;insight;interest;Investigation;Joints;Kinetics;Knowledge;laboratory experiment;Link;Malignant Neoplasms;Medical;Medicine;Metabolic;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;Motion;mutant;Mutate;Mutation;Nature;neuron loss;novel strategies;novel therapeutics;Output;Pancreas;Paper;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Play;Poison;Positioning Attribute;Process;protein data bank;protein structure;Proteins;Publications;Reaction;reaction rate;Relaxation;Research;Ribonucleases;Roentgen Rays;Role;Sampling;side effect;simulation;small molecule;software development;Solvents;Structure;success;Surface;System;Techniques;Testing;Thermodynamics;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Biophysical Model of Enzyme Catalysis: Conformational sub-states, solvent coupling and energy networks

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Prevention

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Narrative The overall goal of parent Lung Health Cohort (LHC) Study is to establish a US community-based longitudinal cohort of young adults to better understand the earliest indicators of lung disease, thus providing important public health insights. The purpose of this ancillary study is to provide detailed or sensitive lung function measures to the funded LHC study. The mechanistic hypothesis is that some persons have a mismatch of airways and blood vessels both in terms of structure and function, and this mismatch will be a marker of early and incident lung disease.

PI_NAMEs: IRVIN, CHARLES G (contact);KAMINSKY, DAVID A;MCCORMACK, MEREDITH C;WASHKO, GEORGE R

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Adult;Age;Air Pollution;airway hyperresponsiveness;Allergic rhinitis;Ancillary Study;Asthma;Blood Vessels;Body mass index;Carbon Monoxide;Cardiac;Child;Childhood Asthma;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;cohort;Cohort Studies;Communities;COVID-19;Data;Diffusion;Disease;Disease Progression;Electronic cigarette;Environmental Risk Factor;Ethnic Origin;Exercise;Funding;Future;Gases;Goals;Growth;Heart;Heart Atrium;heart dimension/size;Impairment;Individual;Infrastructure;injured airway;innovation;insight;Investigation;Knowledge;Left;Left Ventricular Mass;Link;Longitudinal cohort;Lung;Lung Capacity;Lung Diseases;lung health;lung volume;Marijuana;Measures;Morphology;National Heart, Lung, and Blood Institute;Nature;Obesity;Oscillometry;Oxygen;Oxygen saturation measurement;Parents;Participant;Pathogenesis;Persons;Phenotype;Predisposition;premature;prevent;Prevention strategy;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Questionnaires;Recording of previous events;recruit;Respiratory Signs and Symptoms;Risk Factors;Role;sex;Smoker;Spirometry;Structure;Structure of parenchyma of lung;Tobacco;Validation;Walking;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Deep Functional Phenotyping of the ALA Lung Health Cohort

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  The metastatic spread of cancer cells relies on the ability of these cells to invade into tissue surrounding the tumor. Cancer cells use specialized structures called filopodia to move through tissues and spread throughout the body. The work in this proposal will define how cells make filopodia using a simple model system and will thus aid in the development of therapeutics to block their formation.

PI_NAMEs: TITUS, MARGARET A (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Amoeba genus;axon guidance;Biological Assay;Biological Models;cancer cell;Cell Communication;cell motility;cell type;Cells;Cellular Structures;cohort;Complex;crosslink;Dictyostelium;Dictyostelium discoideum;Environment;Epithelium;Event;experimental study;Filopodia;Fluorescence Resonance Energy Transfer;Generations;Head;high resolution imaging;Human;imaging approach;in silico;In Vitro;in vitro Assay;in vivo;insight;Invaded;Knowledge;Lead;Length;Mammalian Cell;mathematical model;Mediating;Membrane;Microfilaments;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motor;Motor Activity;Myosin ATPase;Nature;Neurons;Nonmuscle Myosin Type IIA;Organism;Polymerase;polymerization;Polymers;Process;Property;Proteins;recruit;Regulation;Role;Signal Transduction;social;Structure;Tail;Testing;therapeutic development;Tissues;tumor;vasodilator-stimulated phosphoprotein;Visualization;Work

PROJECT_TITLE: Mechanism of myosin motor-dependent filopodia formation


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE: IgE-mediated food allergy is a growing public health concern. Allergen-specific IgE is largely responsible for the clinical manifestations of allergic reactions, such as life-threatening anaphylaxis. The affinity of the IgE plays a major role in determining the outcome of a patient after exposure to food allergen. IgE that is of high affinity can trigger anaphylaxis, while IgE of low affinity poses little risk and may even be preventative. It is well understood that IgG memory B cells can differentiate into IgE producing plasma cells; however, not enough is known on the distinct pathways involved to form high affinity, rather than low affinity IgE, have not been described. This proposal seeks to understand the intrinsic characteristics and/or external cues that regulate memory B cell differentiation into IgE plasma cells. We expect that outcomes of this work will identify immunotherapeutic approaches for the treatment of food allergy.

PI_NAMEs: REDES, JAMIE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adoptive Cell Transfers;Affect;Affinity;Allergens;Allergic Reaction;Allergy to peanuts;Anaphylaxis;Antibodies;Antigens;B cell differentiation;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;Binding;Biological;career;CD80 gene;Cell Degranulation;cell motility;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Child;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cues;cytokine;Data;Detection;differential expression;Disease;egg;Exposure to;Flow Cytometry;Food;food allergen;Food Hypersensitivity;Functional disorder;Genetic Engineering;Genetic Transcription;Growth;Gut Mucosa;Heterogeneity;Human;Hypersensitivity;IgE;IgG1;Immunity;Immunize;Immunoglobulin Class Switching;Immunoglobulin G;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;Impairment;improved;in vivo;Individual;Laboratories;Life;Lymphoid Tissue;mast cell;Mediating;Memory;Memory B-Lymphocyte;Milk;Mission;Modeling;Molecular;mouse model;Mus;National Institute of Allergy and Infectious Disease;new therapeutic target;novel;Outcome;Outcome Study;pathogen;Pathogenicity;Pathway interactions;Patients;Phenotype;Plasma Cells;Play;Population;Prevalence;Probability;Process;Production;Public Health;Quality of life;Research;Research Personnel;response;Risk;Role;selective expression;Signal Transduction;single-cell RNA sequencing;Structure of germinal center of lymph node;Surface;System;Techniques;Testing;Therapeutic Intervention;Tissue Stains;Tissues;training opportunity;Trust;Variant;Work

PROJECT_TITLE: Characterizing the IgG1 Memory B cells that are precursors of pathogenic IgE


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Callous-unemotional traits, which are defined as deficits in empathy, prosociality, and guilt, are highly heritable and can be observed by 3 years of age. This study aims to examine whether the relationship between parent’s CU traits and children’s early-emerging CU traits is mediated by heritable changes in brain connectivity that are present at birth, prior to postnatal environmental exposures. This work may identify brain differences that precede the onset of callous-unemotional traits and are useful targets for earlier and more effective brain-based treatments.

PI_NAMEs: BRENNER, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 3 year old;Address;Adolescent;adverse outcome;Affect;Affective;Age;Aggressive behavior;Amygdaloid structure;Anterior;antisocial behavior;Area;Behavior;Behavior assessment;Biological;Birth;Brain;brain based;callous unemotional trait;career;Child;Child Development;Child Rearing;cingulate cortex;Code;cohort;comorbidity;Conduct Disorder;conduct problem;Data;Data Collection;Development;Dimensions;Disease;early childhood;Early Intervention;Educational Status;emotion regulation;Emotional;Emotions;Empathy;Environmental Exposure;Environmental Risk Factor;Equipment and supply inventories;experience;Fathers;Functional disorder;Functional Magnetic Resonance Imaging;Genes;Genetic;genetic variant;Guilt;Heritability;high risk;Impairment;improved;Infant;insight;Insula of Reil;Light;Link;Longitudinal cohort;Longitudinal Studies;longitudinal, prospective study;maternal stress;Measures;Mediating;Mediation;Mental Health;Mentorship;Methods;Modeling;Mothers;Neonatal;neonatal brain;neonatal magnetic resonance imaging;neonatal period;neonate;neural;neuroimaging;Neurotransmitter Receptor;Neurotransmitters;Newborn Infant;novel;Nursery Schools;offspring;parental influence;Parents;Pathology;Patient Self-Report;Patients;Physicians;postnatal;Prefrontal Cortex;prenatal;Prognosis;programs;prospective;prospective test;psychopathic personality;Psychopathology;Questionnaires;recruit;Research;Rest;Risk;Role;Sampling;Scientist;skills;social;socioeconomic adversity;Specificity;Substance Use Disorder;Symptoms;Testing;Toddler;treatment response;Twin Studies;Variant;Work

PROJECT_TITLE: Neonatal Functional Connectivity Associated with Callous-Unemotional Behaviors in Preschoolers


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: JACKSONVILLE

ORG_NAME: NEMOURS CHILDREN'S CLINIC

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study is relevant to public health because many school-age children with type 1 diabetes and their parents experience diabetes distress, which may go under-recognized and undertreated leading to persistent distress and sub-optimal levels of diabetes self-care and glycemic control. Current clinical care guidelines recommend routinely screening children (8 years and older) and their parents for diabetes distress during diabetes clinic visits. If the aims of this project are achieved, the result will be a new screen-to-treat programfor diabetes distress targeting school-age families that could be realistically deployed in a clinical setting, ready to test in a larger trial, and scalable for widespread implementation.

PI_NAMEs: PATTON, SUSANA R (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: 12 year old;8 year old;acceptability and feasibility;Address;Adopted;American;Anger;Behavior Therapy;Behavioral;Behavioral Model;Caregivers;Caring;Child;Childhood diabetes;Clinic;Clinic Visits;Clinical;clinical care;Clinical Trials;clinically relevant;Cognitive;Cognitive Therapy;comparative effectiveness;Complex;Complications of Diabetes Mellitus;Consumption;Continuous Glucose Monitor;coping;cost effective;crowdsourcing;Data;data registry;Depressed mood;design;diabetes distress;Diabetes Mellitus;diabetes self-management;Distress;Educational Curriculum;Emotional Stress;evidence base;experience;Family;feasibility testing;Foundations;Fright;Future;Glucose;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Grief reaction;Guidelines;high risk;Hybrids;Hypoglycemia;implementation science;improved;innovation;Insulin-Dependent Diabetes Mellitus;interest;Knowledge;Learning;Longitudinal Studies;Mathematics;Measures;Memory;Mental Depression;mHealth;mhealth interventions;mindfulness;Modality;Modeling;Modernization;multidisciplinary;novel;Outcome;parenting intervention;Parents;Pathway interactions;patient subsets;Persons;Phase;programs;promote resilience;Public Health;Recommendation;recruit;Reporting;Research;Research Design;Research Personnel;Resources;response;restraint;routine screening;School-Age Population;Schools;Scientist;screening;screening program;Series;skills;standard of care;System;Techniques;telehealth;Testing;Therapeutic;therapy development;Time;time use;trend;United States;uptake;Youth

PROJECT_TITLE: Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-Age Families


ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative  The goal of this project is to carry out a detailed study of a key protein, the sodium/iodide symporter (NIS)—a molecule present most notably in the thyroid gland, where it is responsible for the critical first step in the production of the thyroid hormones. One of our research groups was the first to clone and characterize NIS, and our two groups have since collaborated to uncover the characteristics of the molecule and understand them in detail—characteristics including how it handles the molecules it transports (e.g., sodium and iodide) and other molecules that modify its mechanism of action, such as the environmental pollutant perchlorate. In this project, our two groups will continue to use a highly innovative approach that combines biochemical experiments with computational analysis to obtain structure/function and mechanistic information on NIS that will, without a doubt, considerably deepen our understanding of this crucial protein and of other proteins that transport ions and/or molecules across biological membranes.

PI_NAMEs: CARRASCO, NANCY  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affinity;Allosteric Site;Amino Acid Substitution;Anions;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Birth;Calorimetry;cancer therapy;Cell membrane;Cells;Characteristics;Cloning;Collaborations;Computer Analysis;Computing Methodologies;contaminated drinking water;Couples;Data;Defect;Development;drinking water;driving force;Electrophysiology (science);Environmental Pollutants;environmental transport;Equilibrium;experimental study;extracellular;Free Energy;Gene Transfer;Goals;Health;Homology Modeling;hormone biosynthesis;Human;Hydrophobicity;Impaired cognition;Individual;inhibitor;innovation;internal radiation;Iodides;Ion Transport;Ions;Kinetics;Malignant neoplasm of thyroid;Measurement;Mediating;Membrane;Membrane Potentials;Membrane Proteins;Modeling;Molecular Conformation;mutant;Mutation;Nature;novel;Oncogenes;Perchlorates;Physiological;Play;Population;Predisposition;prevent;Production;Property;protein transport;Proteins;proteoliposomes;Public Health;reconstitution;Regulation;Research;simulation;Site;Site-Directed Mutagenesis;Sodium;stoichiometry;Structure;symporter;Testing;Thermodynamics;Thyroid Gland;Thyroid Hormones;Thyroidectomy;Time;Titrations;Uncertainty;uptake

PROJECT_TITLE: Mechanism of I- transport by the Na+/l- symporter (NIS)

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This K24 Mid-Career Mentoring Award will support the further career development and 50% protected time for my mentoring and research. Through the K24 award, I will gain additional training in dissemination /implementation research and health equity research. The K24 will leverage my current R01 to serve as a training platform for trainees and incorporate my career development objectives, ultimately advancing the ability to disseminate interventions to preserve physical function in older people with HIV and support patient- oriented researchers.

PI_NAMEs: ERLANDSON, KRISTINE MACE (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Adult;Age;aged;Aging;Award;Behavioral;Biological;Cardiovascular system;career;career development;Clinic;Clinical;clinical care;Clinical Management;Clinical Trials;Communicable Diseases;Communities;community based research;Data;design;Development Plans;Discipline;Dissemination and Implementation;effective intervention;Effectiveness of Interventions;Elderly;Elements;Ensure;Epidemiology;Evaluation;evidence base;Exercise;exercise intensity;exercise intervention;exercise prescription;experience;Feedback;functional decline;Funding;Future;Geriatric Assessment;Geriatrics;Goals;Group Interviews;Guidelines;Health;health data;health disparity;health equity;Health equity research;healthy aging;HIV;Impairment;implementation research;improved;Income;Individual;informant;Institution;Interval training;Intervention;Interview;Knowledge;Leadership;Location;Lower Extremity;Measurement;Measures;member;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Minority Groups;Modality;Modeling;Modification;motivational enhancement therapy;Muscle;muscle form;National Institute on Aging;older adult;Older Population;Outcome;Outcome Assessment;Parents;Participant;patient oriented;patient oriented research;Patients;Persons;Physical activity;Physical Function;portability;Positioning Attribute;Poverty;pragmatic implementation;preference;preservation;prevent;Process;programs;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;resistance exercise;Risk;Role;Scanning;Science;social culture;Structure;Surveys;systematic review;Text Messaging;Thick;Time;tool;Training;ultrasound;Upper Extremity;uptake;Work

PROJECT_TITLE: Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on Mobility

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE A thorough understanding of the regulatory networks that govern cardiomyocyte maturation is essential for development of successful regenerative strategies and targeted molecular therapies. The goal of this project is to functionally characterize select factors and cis-regulatory elements within these networks.

PI_NAMEs: VANDUSEN, NATHAN JAMES (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Adult;Birth;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;chromatin modification;Complex;conditional knockout;congenital heart abnormality;Congenital Heart Defects;CRISPR screen;Data;Defect;Deposition;Development;Disease;disease model;Dissection;Down-Regulation;Epigenetic Process;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;Heart;Heart failure;heart function;hemodynamics;Histone H2B;histone modification;Histones;Homeostasis;Human;Hypertrophic Cardiomyopathy;Hypertrophy;improved;in vivo;Incidence;insight;loss of function;Maps;Mentors;Metabolism;Molecular;molecular targeted therapies;Monoubiquitination;Morphology;Mus;Mutate;Mutation;Myosin ATPase;Myosin Heavy Chains;Neonatal;neonate;novel;Operative Surgical Procedures;Palliative Surgery;Pathologic;Patients;Phase;Phenotype;Process;Production;promoter;Protein Isoforms;Protocols documentation;regenerative approach;Regenerative Medicine;Regulation;Regulatory Element;Replacement Therapy;Repression;response;Role;Sarcomeres;sound;Stress;targeted treatment;tool;transcription regulatory network

PROJECT_TITLE: Functional dissection of the regulatory network that governs cardiomyocyte maturation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Women's Health Research

PHR: Project Narrative Significant sex differences exist in glioblastoma incidence and survival have been repeatedly documented. However, the implications of these observations, and other observations like them in other cancers, have yet to be routinely incorporated into laboratory-based cancer research and the implications for cancer treatments have not been evaluated. Here, we investigate sex differences in cellular responses to DNA damage. This innovative focus will yield novel insights and support new directions in lab-based and clinical research aimed at curing glioblastoma. !

PI_NAMEs: RUBIN, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Affect;American;anti-cancer research;Astrocytes;base;Biological;Biological Models;Bone Marrow;Brain;Brain Neoplasms;Breast Cancer Model;cancer therapy;Cell Aging;Cell model;Cells;chemokine;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical Research;cytokine;defined contribution;DNA Damage;Endowment;Epigenetic Process;Etoposide;Evaluation;Exhibits;experience;Female;Fibroblasts;FRAP1 gene;Funding;Gene Expression Profile;Genomics;Glioblastoma;Goals;Growth Factor;Human;Hydrogen Peroxide;improved outcome;In Vitro;Incidence;Inflammatory;innovation;insight;Investigation;Knowledge;Laboratories;male;Malignant Neoplasms;Modeling;Molecular;mouse model;Mus;neoplastic cell;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;novel;novel strategies;Pathologic;Pathway interactions;Patients;Phosphorylation;Play;Ploidies;Property;prostate cancer model;Publishing;Radiation;Regulation;Reporting;Repressor Proteins;Research;response;Role;senescence;senescence associated secretory phenotype;senescent cell;Severities;sex;Sex Chromosomes;Sex Differences;Sex Differentiation;sex disparity;sexual dimorphism;Stromal Cells;success;Techniques;Technology;Therapeutic;tool;TP53 gene;Translations;treatment optimization;treatment response;tumor growth;Tumor Promotion;tumorigenesis;tumorigenic

PROJECT_TITLE: Molecular basis for the impact of sex on brain tumorigenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Physical Activity;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Walking is important for maintaining independence and is highly valued by older adults. We plan to examine the real-world effectiveness of On the Move, a group exercise program to improve walking in older adults, when taught by community instructors. Our study will determine the value of offering On the Move as a health and wellness program for older adults in the community.

PI_NAMEs: BRACH, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;Adherence;Affect;Aging;American;arm;Certification;Clinical;cluster randomized design;Cluster randomized trial;Communities;community center;community setting;Competence;Control Groups;Controlled Environment;cost;Development;diaries;Dose;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness trial;evidence base;Exercise;exercise program;Focus Groups;follow-up;Funding;future implementation;Gait speed;Health;Health Care Costs;Health Promotion;Hybrids;implementation efforts;improved;improved mobility;Individual;innovation;instructor;instrument;Intervention;Intervention Studies;Interview;Life;Measures;meetings;Monitor;older adult;Outcome;Participant;Patient Self-Report;post intervention;primary outcome;programs;Provider;Randomized;Research;Research Personnel;Resource-limited setting;Resources;Rural;Testing;Training;Translating;Translations;treatment as usual;Walking;Wellness Program

PROJECT_TITLE: Effectiveness of the On the Move group exercise program to improve mobility in community-dwelling older adults

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Corticosteroids are among the most prescribed drugs in the world, important for the treatment of numerous forms of heart failure and chronic inflammation. This work will dissect mechanisms of corticosteroids in the etiology and treatment of dystrophic cardiomyopathy, using steroid receptor mutations as well as mouse models of Duchenne and Becker muscular dystrophy. By identifying corticosteroid mechanisms that can be selectively targeted, we will provide a basis for improved muscular dystrophy treatments and enable drug development in other diseases with cardiomyopathy or chronic inflammation.

PI_NAMEs: HEIER, CHRISTOPHER RYAN (contact)

PROJECT_TERMS: Ablation;Address;Adrenal Cortex Hormones;Affect;Agonist;Animal Model;Animals;antagonist;Anti-Inflammatory Agents;Asparagine;Becker Muscular Dystrophy;Binding;Biological Models;Cardiomyopathies;cardioprotection;Cell Culture Techniques;Cells;Childhood;Chronic;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;coronary fibrosis;Corticosteroid Receptors;Data;Disease;Dissociation;drug development;drug discovery;Drug Prescriptions;Drug Targeting;Duchenne muscular dystrophy;dystrophic cardiomyopathy;Dystrophin;effective therapy;Etiology;exon skipping therapy;Gene Expression;gene therapy;Genes;Genotype;Glucocorticoid Receptor;Goals;Grant;Heart;Heart Diseases;Heart failure;Human;Hydroxysteroids;Immune;improved;improved outcome;Inflammation;Inflammatory;Knock-out;Knockout Mice;Knowledge;Ligands;LoxP-flanked allele;mdx mouse;Mediating;Methodology;micro-dystrophin;MicroRNAs;Mineralocorticoid Receptor;Modeling;Molecular;mortality;mouse model;Mus;Muscle;Muscular Dystrophies;Mutation;Myocardial dysfunction;Myocardium;Myopathy;novel;novel therapeutics;Outcome;Pathology;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Phenotype;Physiological;Point Mutation;Positioning Attribute;Prednisone;receptor;Receptor Activation;restoration;Role;Safety;Serum;side effect;Signal Transduction;Skeletal Muscle;standard of care;Steroid Receptors;Steroids;Structure;System;Testing;Tissues;tool;Transactivation;Work

PROJECT_TITLE: Mechanisms of corticosteroids in dystrophic cardiomyopathy

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ED_INST_TYPE: UNIVERSITY-WIDE

PHR: Project Narrative The intestinal epithelium is a critical interface between our body and the environment of our intestinal lumen, coordinating intestinal immune responses and shaping our gut microbial composition. However, how intestinal cells recognize beneficial gut bacteria, and which intestinal cell responses promote their selection within the gut remains poorly understood. This project addresses fundamental questions to improve our understanding of how intestinal innate immunity influences and is influenced by gut bacteria using the model organism C. elegans, providing the fine-sale spatial resolution needed to dissect the intricacies of host-microbe interactions in the gut.

PI_NAMEs: HILL, JESSICA L (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adaptive Immune System;Address;Adult;antimicrobial;Atlases;Bacteria;Biological Models;Biological Process;C-Type Lectins;Caenorhabditis elegans;career;Cause of Death;Cell Differentiation process;Cells;cohort;commensal bacteria;commensal microbes;Communicable Diseases;Communities;Data;Data Set;Defense Mechanisms;Development;developmental genetics;Disease;dysbiosis;Embryo;Environment;Epithelial Cells;Escherichia coli;Exhibits;Exposure to;Foundations;Gastrointestinal tract structure;Gene Family;Genes;Genetic Models;Genetic Transcription;gut bacteria;gut microbes;gut microbiome;gut microbiota;Home;host-microbe interactions;Human;Immune;immune function;Immune response;Immunologic Receptors;immunoregulation;improved;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;insight;intestinal epithelium;Intestines;Investigation;Maintenance;Mammals;Mediating;Mediator;Microbe;microbial;microbiome;microorganism;Microscopy;model organism;Modeling;Molecular Biology;Natural Immunity;novel;oral vaccine;Organ;pathogen;Pathogenicity;Pathway interactions;Pattern;Pattern recognition receptor;Play;Polysaccharides;prevent;Process;Protocols documentation;Pseudomonas aeruginosa;receptor;Research;Research Personnel;Resolution;response;RNA Interference;Role;Sales;Shapes;single-cell RNA sequencing;Surveys;System;targeted treatment;Techniques;Testing;Training;transcriptome;Work

PROJECT_TITLE: Caenorhabditis Elegans: a Model for Genetic Interaction between the Gut Microbiota and Intestinal Epithelial Cells


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Kidney Disease;Mental Health;Mental Illness;Organ Transplantation;Prevention;Social Determinants of Health;Transplantation

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Psychiatric disorders are highly prevalent following kidney transplantation (KT) and significantly reduce survival and quality of life of kidney transplant recipients; however, to date, most studies of risk factors for psychiatric disorders have been small or restricted to retrospective data collection after KT. The overarching aim of this proposal is to systematically investigate genomic, clinical, and psychosocial contributors to MDD and PSTD following KT to improve our ability to understand and mitigate risk of psychiatric disorders for KT recipients. Kidney disease disproportionately impacts traditional US minorities, and most KT recipients are not of European ancestry, so this proposal will build on innovative efforts to apply genomic data to patients with non-European ancestry.

PI_NAMEs: NASH, REBEKAH POTTS (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Abbreviations;Abdomen;Applied Genetics;Biochemistry;biopsychosocial;biopsychosocial factor;career;Cessation of life;Chronic;Clinical;clinical care;Clinical Data;clinical database;Clinical Research;Cognitive;cognitive function;cohort;Cohort Studies;comorbidity;Consent;Data;Data Analyses;Data Collection;database design;design;Dialysis procedure;Disease;DNA;DNA purification;Doctor of Philosophy;Documentation;Drug Kinetics;Electronic Health Record;End stage renal failure;Enrollment;Etiology;European;European ancestry;Event;experience;Exposure to;Feasibility Studies;Fellowship;Foundations;Funding;Future;Genetic;genetic association;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genomic data;Genomics;Genotype;Goals;Graft Rejection;Immunosuppression;Impairment;improved;Incidence;Inherited;innovation;Institutional Review Boards;International;Kidney Diseases;Kidney Failure;Kidney Transplantation;Length;Maintenance;Major Depressive Disorder;Measures;Medical;medication nonadherence;member;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Minority;Modeling;Mood Disorders;Natural experiment;Operative Surgical Procedures;organ transplant recipient;Organ Transplantation;Outcome;Participant;patient oriented;Patients;Physicians;Post-Traumatic Stress Disorders;Predictive Factor;predictive modeling;Prevalence;Procedures;Prognosis;programs;prospective;Prospective cohort;Prospective, cohort study;psychiatric comorbidity;psychiatric symptom;Psychiatrist;psychogenetics;psychologic;psychosocial;Psychosocial Factor;Publishing;Quality of life;Registries;Renal function;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;risk mitigation;Sampling;Scientist;sociodemographics;Solid;Statistical Data Interpretation;stressor;Suicide;Survey Methodology;Testing;Time;Training;trait;Transplant Recipients;Transplantation;Uncertainty;Validation;Work

PROJECT_TITLE: Biopsychosocial Risk Factors for Psychiatric Disorders Following Kidney Transplantation

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Kidney Disease;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Urinary tract infections are common bacterial infections in women, but also affect male populations, in some cases with worse outcomes. Infections of the kidney can result in renal scars, which carry risk for chronic kidney disease later in life. In this work, we will use traditional and cutting-edge scientific approaches to reveal how sex and sex hormones affect susceptibility to, and outcomes of, kidney infection.

PI_NAMEs: EARL, ASHLEE MIRIAM;HUNSTAD, DAVID  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: activin A;Acute;Affect;Anatomy;Androgen Receptor;Androgenization;Androgens;Antibiotics;Automobile Driving;Bacteria;Bacterial Infections;Bacterial RNA;Biological Assay;Bladder;bladder surgery;Bypass;Catheters;Cell Culture System;cell type;Child;Chronic Cystitis;Chronic Kidney Failure;Cicatrix;Collaborations;Communities;Complex;Complication;conditional knockout;Data;Emerging Technologies;epidemiologic data;Epidemiology;Epithelial Cells;Escherichia coli Infections;Exhibits;experimental study;Female;Flow Cytometry;Functional disorder;Gastrointestinal tract structure;Gene Expression;Genetic Transcription;Germ Lines;Gonadal Steroid Hormones;Health;Healthcare;Histology;Hormonal;Human;Hybrids;Hypertension;Immune response;In Vitro;in vivo;Inbred C3H Mice;Incidence;Infection;infection management;infection risk;Infective cystitis;innovation;insight;Kidney;kidney fibrosis;kidney infection;Knock-out;Knockout Mice;Laboratories;Leukocytes;Life;Link;long-term sequelae;Macrophage;male;Mediator;men;Methods;Microscopy;minimally invasive;Modeling;Molecular;Morbidity - disease rate;mortality;Mouse Strains;Mus;mutant;Myofibroblast;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Phenotype;Polycystic Ovary Syndrome;Population;pre-clinical;Pre-Clinical Model;Predisposition;prevent;programs;prototype;Publishing;recruit;Recurrence;renal abscess;renal epithelium;renal scarring;Resolution;response;Risk;Severities;sex;Sex Differences;SHH gene;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;Specific qualifier value;Specificity;Techniques;Technology;Testing;Time;transcriptome sequencing;Transforming Growth Factor beta;Tubular formation;Universities;Urethra;Urinary tract;Urinary tract infection;Uropathogenic E. coli;Vesico-Ureteral Reflux;Virulence;Virulence Factors;virulence gene;Washington;Western Blotting;Woman;Work;young adult

PROJECT_TITLE: Cellular and Molecular Basis of Sex Specificity in UTI Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Patient Safety;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PHR: IMPACT OF IMMUNE SEX DIFFERENCES IN THE FIRST 1000 DAYS OF LIFE  AND IN CHILDHOOD AND ADOLESCENCE PROJECT NARRATIVE We believe the reason that sex-specific prevention and treatment strategies have not been developed, even in this age of precision medicine, is that the underlying mechanisms have not been established. In this project we seek to demonstrate that immune sex differences are present in early life, starting in utero, and that these have considerable impact on the protective responses to vaccines, such as BCG, measles vaccine and COVID-19 vaccines, and to outcome from infections such as HIV. Through investigations of sex-discordant twins, mother-child and adolescent cohorts, we will analyse innate and adaptive immunity, DNA methylation and sex steroid profiles to address the fundamental mechanisms underlying early life immune sex differences, that form the basis for lifelong outcomes in response to vaccines and infections.

PI_NAMEs: GOULDER, PHILIP J (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: adaptive immunity;Address;Adolescence;Adolescent;Adult;Adverse event;Affect;Age;age related;aged;Agonist;Androgens;Antibody Response;Autoimmune Diseases;Bacille Calmette-Guerin vaccination;Birth;Cells;Child;Childhood;cohort;Cohort Studies;Conceptions;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Diet;Disease;DNA;DNA Methylation;Environment;Epigenetic Process;Ethnic Origin;Evaluation;Female;Fetus;Genes;Gonadal Steroid Hormones;Health;high risk;HIV;human old age (65+);Immune;immune function;Immune response;Immunity;Immunization;Immunization Schedule;immunopathology;immunoregulation;improved;in utero;Individual;Infection;Inflammatory;Interferon Type I;Interferons;Investigation;Licensing;Life;Long COVID;male;Maternal antibody;Measles;Measles Vaccine;Medical;methylome;mortality;mortality risk;Mothers;Natural Immunity;Nature;neutralizing antibody;Observational Study;Outcome;Pattern;Pfizer-BioNTech COVID-19 vaccine;placental transfer;precision medicine;Predisposition;Pregnancy;prenatal exposure;Prevention;Prevention strategy;Production;Regulation;Resistance;response;RNA Viruses;Role;Serious Adverse Event;seroconversion;sex;Sex Differences;Signal Pathway;Site;South Africa;T-Lymphocyte;TLR7 gene;treatment strategy;Tuberculosis;Twin Multiple Birth;Twin Studies;Vaccination;vaccination outcome;vaccine adverse event;Vaccines;virtual;Virus;young adult

PROJECT_TITLE: Impact of immune sex differences in the first 1000 days of life and in childhood and adolescence


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Overall Section  This proposal focuses on elucidating the genomic and microenvironmental determinants, and temporal dynamics underlying efficacy of radiation-based combination therapies. We will use an innovative molecular characterization trial testing radiation plus antibody-drug conjugate in bladder cancer and radiation plus immunotherapy in head and neck cancer to characterize the mechanistic drivers underlying these next generation RT-based therapies. Our studies will help build a foundation to optimize multimodal, radiation- based definitive treatment strategies.

PI_NAMEs: CHAN, TIMOTHY AN-THY (contact);YU, DAVID SUNG-WEN

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Antibody-drug conjugates;antitumor effect;Automobile Driving;Biography;Biological Markers;Biological Products;Bladder;Breast Cancer Patient;Cancer Patient;cancer therapy;cancer type;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Cisplatin;Clinic;Clinical;Combined Modality Therapy;Data;Disease;DNA Damage;Event;Foundations;Gene Expression;Genetic;Genetic Transcription;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunologic Factors;Immunologics;Immunotherapy;improved;improved outcome;innovation;insight;International;Malignant neoplasm of urinary bladder;Modality;Molecular;multidisciplinary;multimodality;Mutation;next generation;Oncology;Outcome;Pathogenesis;Patients;preservation;programs;Radiation;radiation effect;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;radiomics;Research;Research Personnel;Resistance;response;Robin bird;Roentgen Rays;standard of care;Testing;Therapeutic;Treatment Efficacy;treatment strategy;tumor;Work

PROJECT_TITLE: Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

PI_NAMEs: CHAN, TIMOTHY AN-THY (contact)

PROJECT_TERMS: Accounting;Animal Experimentation;Animals;Cancer Center;Clinic;Clinical;Clinical Management;Clinical Trials;Collaborations;Combined Modality Therapy;Communication;Comprehensive Cancer Center;Core Facility;Data;Development Plans;Documentation;Education;Enrollment;Ensure;experience;Feedback;Florida;Funding;Genomics;Goals;Grant;Human;Human Resources;human subject;Human Subject Research;Individual;innovation;Institution;Investigation;Laboratories;Leadership;Manuscripts;meetings;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;National Cancer Institute;Office of Administrative Management;operation;Oral;Performance;Preparation;programs;Progress Reports;Radiation;Research;Research Personnel;Resources;Schedule;Services;Site;Study Subject;System;Time;Training;Treatment Efficacy;Universities;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Radiation Oncology;Urologic Diseases

PI_NAMEs: MIAN, OMAR Y (contact)

PROJECT_TERMS: Address;Adjuvant;anti-PD-1;Antibody-drug conjugates;Antineoplastic Agents;antitumor effect;Biological;Bladder;Blood;Cancer Patient;cancer type;chemoradiation;Cisplatin;Clinical;Clinical Data;cohort;Cohort Studies;Collection;Combined Modality Therapy;Cytotoxic agent;Data;data acquisition;design;Disease;Foundations;Genetic;Genomics;Goals;Head and Neck Squamous Cell Carcinoma;Hybrids;Image;Immune;immune checkpoint blockade;Immunologics;immunomodulatory therapies;immunoregulation;Immunotherapy;improved outcome;insight;Intensity-Modulated Radiotherapy;irradiation;Knowledge;Laboratories;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Modality;Molecular;multimodal data;muscle invasive bladder cancer;next generation;Nivolumab;Pathogenesis;Patients;phase II trial;precision medicine;preservation;Radiation;radiation effect;Radiation Oncology;radiation resistance;Radiation therapy;Radiobiology;Recurrence;Research;Research Personnel;Resistance;response;Robin bird;sample collection;Sampling;Site;Specimen;Squamous cell carcinoma;standard of care;Statistical Methods;Surveys;targeted agent;Testing;Therapeutic;Time;Tissues;Treatment Efficacy;treatment response;trial design;tumor

PROJECT_TITLE: Molecular Characterization Trial


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE To address the need for robust gene-editing delivery systems to T cells in situ, we propose to engineer an unprecedented “Ad.AAV” nano-vector system consisting of multiple T cell-tropic adeno-associated viruses (AAVs) conjugated to a T cell-tropic adenovirus (Ad) on its capsid's surface. By virtue of combining the advantages of each virus in this conjoined form, our system holds the promise of greatly enhancing the tissue targeting specificity and efficiency and improving safety profile of existing CRISPR-Cas gene editing therapies. As a proof of concept, we plan to achieve efficient production of the heart disease-targeted CAR-T cells via the Ad.AAV-mediated knock-in of a switchable CAR transgene in the T cells in vivo in mice.

PI_NAMEs: LU, ZHI HONG  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Adenoviruses;Adverse effects;base editing;Biomedical Engineering;Capsid;CAR T cell therapy;Cell Therapy;cell type;Chemistry;chimeric antigen receptor T cells;Clinical;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;coronary fibrosis;cost;Coupling;delivery vehicle;Dependovirus;design;Development;Disease;DNA;Engineering;Fiber;gene delivery system;gene editing technology;Gene Expression;gene-editing approach;Generations;Genes;Genetic;Genetic Transcription;Genome;genome editor;Guide RNA;Heart;Heart Diseases;Human;Imagination;improved;In Situ;In Vitro;in vivo;Intervention;Knock-in;Link;Mediating;Methods;mouse model;Mus;nanovector;National Heart, Lung, and Blood Institute;neoplastic;novel;Organ;Pan Genus;Patients;practical application;pragmatic implementation;Production;Proteins;receptor;repaired;Reporting;Running;Safety;Serotyping;Simian Adenoviruses;Specificity;Sum;Surface;System;T-Lymphocyte;Techniques;Technology;technology platform;technology validation;therapeutic genome editing;Time;Tissues;transduction efficiency;transgene expression;Transgenes;vector;Viral;Virus

PROJECT_TITLE: A Novel Vector Strategy to Feasibilize Cellular Therapy for Heart Disease

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


PROJECT_TERMS: Antibodies;Antibody-drug conjugates;antitumor effect;ATM Gene Mutation;Biological Response Modifiers;Bladder;Blood;cancer cell;Cancer Patient;cell injury;Cells;Cessation of life;checkpoint therapy;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Trials;Clonality;Combined Modality Therapy;Data;Diagnosis;Dissection;DNA Damage;driver mutation;Ecosystem;Evolution;Genes;Genetic;Genetic Transcription;Genomics;Goals;Image;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;Immunologics;improved;improved outcome;irinotecan;Kinetics;Malignant neoplasm of urinary bladder;Modality;Molecular;muscle invasive bladder cancer;Mutation;neoplastic cell;next generation;Operative Surgical Procedures;Organ;Outcome;overexpression;Pathogenesis;Patient Care;Patients;Phenotype;Population;preservation;prospective;Prospective Studies;Radiation;radiation effect;radiation response;Radiation therapy;Research Project Grants;Research Project Summaries;Resistance;resistance mechanism;response;Sampling;single cell sequencing;Somatic Mutation;standard of care;Testing;Therapeutic;TP53 gene;Transurethral Resection;treatment effect;Treatment Efficacy;tumor;tumor-immune system interactions;Urothelium;Variant

PROJECT_TITLE: Project 1 Genetic and Immunologic Mechanisms Underlying Combination Sacituzumab plus Radiation Therapy for Bladder Cancer


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Scientists encounter numerous limitations of studying the human placenta using animal models or cell/tissue cultures from samples obtained from term delivery, which has reduced our understanding of placental functions in normal pregnancy as well as in placental disease-associated adverse pregnancy outcomes (APOs). To overcome these limitations and to better study placental functions, we will develop both normal and disease- state Placenta-Maternal interface organ-on-chip (PMi-OOC) models representing the distinctly different three trimesters of pregnancy. Using these in-vivo-like in vitro models, we will recreate oxidative stress and inflammation-associated placental pathologies that compromise PMi homeostasis, leading to APOs.

PI_NAMEs: RICHARDSON, LAUREN STAFFORD (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 37 weeks gestation;Adverse event;adverse pregnancy outcome;age related;Animal Model;Animals;Anti-Inflammatory Agents;Antioxidants;Biochemistry;Blood;Blood capillaries;Body System;cell growth;cell injury;Cell model;Cell Physiology;cell type;Cells;Cellularity;cigarette smoke;Circulation;Clinical Trials;Complex;cost;Cysteine;Decidua;Decidua Basalis;design;Development;Developmental Delay Disorders;Disease;disease model;efficacy testing;Endothelium;Engineering;Environment;Environmental Impact;Exhibits;exosome;experience;experimental study;fetal;Fetal Growth Retardation;Fetal Membranes;Functional disorder;Gestational Age;Gestational Diabetes;Growth;Homeostasis;Human;Hydrogen Peroxide;Image;Immune;Immunobiology;in utero;in vitro Model;in vivo;Infection;Inflammation;innovation;Interleukin-10;Knowledge;Lead;Lifelong disability;Low Birth Weight Infant;Maternal Mortality;Maternal-Fetal Exchange;Measures;Mediating;Modeling;Molecular;Molecular and Cellular Biology;Morbidity - disease rate;mortality;Neonatal Mortality;nonhuman primate;novel;organ on a chip;Oxidative Stress;Oxidative Stress Induction;Oxygen;Pathology;Perfusion;Pharmaceutical Preparations;Physiological;Physiology;Pilot Projects;Placenta;Placenta Diseases;Placental Biology;placental transfer;Placentation;Population;Pre-Eclampsia;preclinical trial;Pregnancy;Pregnancy Complications;Pregnancy Trimesters;pregnant;Premature Birth;prevent;Proteomics;Research;Risk;Risk Reduction;Role;Safety;Sampling;Scientist;Stromal Cells;Structure;successful intervention;Syncytiotrophoblast;Testing;Therapeutic;tissue/cell culture;Tissues;TNF gene;Toxic Environmental Substances;trophoblast;Villus

PROJECT_TITLE: Developing trimester-specific placenta organ-on-chips to model healthy and oxidative stress and inflammation-associated pathologies

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Genetics;Human Genome;Immunotherapy;Precision Medicine;Radiation Oncology;Urologic Diseases

PI_NAMEs: SCOTT, JACOB GARDINIER (contact)

PROJECT_TERMS: actionable mutation;Admission activity;Adopted;Affect;Alternative Therapies;Antibodies;Antibody-drug conjugates;Antineoplastic Agents;arm;Basic Science;Behavior;Bioinformatics;Biological;Biopsy;Bladder;Cancer Patient;Cell Line;Cells;chemoradiation;chemotherapy;Cisplatin;Clinic;Clinical;cohort;combinatorial;Combined Modality Therapy;computer science;cone-beam computed tomography;Cytology;cytotoxic;Data;Data Set;Decision Making;density;Discipline;Disease;Disparate;Evolution;experience;Failure;Frequencies;Funding;genetic signature;Genetic Transcription;Genomics;Glean;Head and Neck Squamous Cell Carcinoma;Head and neck structure;human genome sequencing;Image;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;individual patient;insight;interest;Intervention;Knowledge;Magnetic Resonance Imaging;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measures;Medical;Medical Oncology;Modality;Modernization;Modification;Molecular;Mutation;Nature;Nivolumab;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pelvis;personalized medicine;Pharmacologic Substance;phase II trial;Phase Transition;Physics;Play;Positron-Emission Tomography;Prediction of Response to Therapy;Primary Neoplasm;Radiation;Radiation Dose Unit;radiation effect;Radiation Oncology;radiation response;Radiation therapy;Radiobiology;radiomics;Refractory;Regimen;Resistance;response;Role;Saliva;Sampling;Site;Specificity;standard of care;Structure;success;synergism;targeted treatment;Techniques;Technology;The Cancer Genome Atlas;Therapeutic;Time;transcriptomics;Translating;Translations;treatment choice;Treatment Efficacy;Treatment Failure;treatment response;tumor;tumor DNA;Tumor Tissue;Urine;Variant

PROJECT_TITLE: Project 2: Transcriptional Dynamics and Temporal Reprogramming During Radiation Treatment


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: YU, DAVID SUNG-WEN (contact)

PROJECT_TERMS: Adjuvant;anti-PD-1;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Automobile Driving;Biological;Biological Markers;biomarker identification;CD8-Positive T-Lymphocytes;checkpoint inhibition;chemotherapy;Cisplatin;Clinical;Clinical/Radiologic;Collection;Combined Modality Therapy;CRISPR screen;Data;DNA Damage;fractionated radiation;Gene Expression;Genes;Genetic;Genomics;Head and Neck Squamous Cell Carcinoma;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;immunogenic;Immunologics;Immunotherapy;improved;insight;Intensity-Modulated Radiotherapy;irradiation;Knowledge;Mediating;Modality;Molecular;multimodal data;Mutation;neoantigens;Nivolumab;Normal tissue morphology;Outcome;Patients;PD-1 inhibitors;Peptide/MHC Complex;Play;Population;progenitor;programmed cell death protein 1;Proteins;Radiation;radiation effect;radiation resistance;radiation response;Radiation therapy;Radiology Specialty;Recurrence;Regulation;Research Project Grants;Research Project Summaries;Resistance;response;Role;Series;Signal Transduction;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor-immune system interactions;Work

PROJECT_TITLE: P3: Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint BlockadeýSUBAWARD


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: Los Angeles

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed research is to explore the usage of focused ultrasound for ejecting cells from their monolayer on a solid platform, without damage on the ejected cells or the cells remaining in the monolayer. An array of focused ultrasonic transducers will be developed and used to eject living cells, without damage, from their monolayer into nearby microwells for single-cell RNA sequencing for quality control in production of retinal pigment epithelium cell monolayer on a scaffold for treatment of age-related macular degeneration (AMD).

PI_NAMEs: KIM, EUN SOK (contact);ZHONG, JOHN

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acoustics;Age;Age related macular degeneration;Age related pathologies;Area;Atrophic;Biopsy;cell injury;Cell Separation;Cell Therapy;Cells;Chromosomes;Clinical;Clinical Trials;Collection;Complex;cost;Data;Derivation procedure;Developed Countries;Development;Diameter;Encapsulated;Epithelial Cells;epithelial to mesenchymal transition;Fingerprint;Focused Ultrasound;Functional disorder;Gel;Genes;Goals;Graft Rejection;human embryonic stem cell;human induced pluripotent stem cells;human stem cells;Immune;Implant;improved;Individual;induced pluripotent stem cell;Interruption;Liquid substance;Measures;Methods;Microfluidics;Microspheres;Modeling;Molecular;Molecular Analysis;Molecular Profiling;monolayer;Nature;Needles;novel;Oils;operation;particle;Pathology;Patients;Persons;Photoreceptors;pluripotency;Pluripotent Stem Cells;Polymerase Chain Reaction;Population;pressure;prevent;Production;Progressive Disease;Protocols documentation;Quality Control;Radiation;Reagent;regenerative;Research;Retina;Retinal Degeneration;Reverse Transcription;scaffold;Shapes;single-cell RNA sequencing;Solid;Spottings;Stem cell transplant;stem cells;Structure of retinal pigment epithelium;subretinal injection;Surface;Suspensions;Technology;Temperature;Testing;Thinness;transcriptome;transcriptome sequencing;Transducers;Transfection;Transplantation;Tumorigenicity;Ultrasonic Transducer;Ultrasonics;ultrasound;Variant;Visual impairment;wound healing

PROJECT_TITLE: Damage-Free, Ultrasonic Cell Isolation from Retinal Pigment Epithelium (RPE) Monolayers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: DIAZ-MONTERO, CLAUDIA MARCELA (contact)

PROJECT_TERMS: Bar Codes;biobank;Bioinformatics;Biological Assay;Biological Markers;Biometry;Cell Survival;Cells;Chairperson;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Computational Biology;computing resources;Data;Data Analyses;Data Collection;data harmonization;data management;Data Management Resources;data resource;Dedications;differential expression;empowerment;Ensure;Flow Cytometry;Generations;Genes;Genomics;Health Sciences;human leukocyte antigen testing;Immunogenomics;Immunologic Monitoring;Immunologics;Immunology;Immunology procedure;Immunooncology;Immunophenotyping;Immunotherapy;interoperability;Laboratories;Molecular;multidisciplinary;Mutation;neoantigens;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Performance;Peripheral Blood Mononuclear Cell;Plasma;preclinical study;Procedures;Process;programs;Proteomics;Quality Control;Radiation;radiation response;radiomics;Reporting;Research Design;Research Personnel;Research Project Grants;Resources;response;Sampling;screening;Sequence Analysis;Specimen;Standardization;Statistical Data Interpretation;T-cell receptor repertoire;T-Lymphocyte;Technology;Tissue Procurements;transcriptome;transcriptomics;translational goal;Translational trial;Treatment Efficacy;treatment response;Tumor Tissue;Whole Blood

PROJECT_TITLE: Translational and Clinical Trial Correlates Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Radiation Oncology

PROJECT_TERMS: Acceleration;Address;Adoption;anti-cancer research;Basic Science;Biological;Biology;Caliber;Cancer Biology;cancer diagnosis;career;Cause of Death;Clinic;Clinical;clinical practice;Clinical Trials;clinically significant;Collaborations;collaborative environment;Combined Modality Therapy;commune;Communities;Community Clinical Oncology Program;community engagement;Comprehensive Cancer Center;Data;data sharing;Detection;Development;Disabled Persons;Doctor of Philosophy;Education;Educational Curriculum;Ensure;Environment;experience;Faculty Workshop;Fostering;Foundations;Future;Genomics;Goals;immunoregulation;improved;Informatics;informatics tool;innovation;insight;Institution;Internships;Knowledge acquisition;leadership development;Malignant Neoplasms;Medical;meetings;Mentors;Mentorship;Minority;Mission;Molecular;multidisciplinary;next generation;Patient Care;Patient-Focused Outcomes;Persons;Physicians;Physics;Postdoctoral Fellow;Program Development;programs;Public Health;Quality of Care;Radiation;Radiation Oncologist;Radiation Oncology;Radiobiology;recruit;Research;Research Personnel;Resources;Rotation;Sampling;Science;Scientist;Services;Site;skills;Standardization;Talents;targeted treatment;Techniques;tool;Training;Training and Education;training opportunity;Training Programs;Translating;Translations;Treatment Efficacy;Universities;virtual;Woman;Workforce Development

PROJECT_TITLE: Cross Training Core


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Malaria is a leading cause of illness and death for children under five years of age globally, with most of these deaths resulting from infection by the Plasmodium falciparum parasite. The process of cell division in the parasite is different from human cells, and the goal of this application is to understand how an essential multi-protein contractile ring, known as the basal complex, controls parasite cell division. Through this understanding, we can identify parasite-specific targets for new anti-malarials.

PI_NAMEs: DVORIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 5 year old;Anti-malarials;asexual;Avidity;Biogenesis;Biological;Biological Process;Biomass;Blood;burden of illness;Cell division;Cell Division Process;Cell Nucleus;Cell Physiology;Cell Shape;Cells;Cessation of life;Child;Chimeric Proteins;Clinical;combinatorial;Complement;Complex;Contractile Proteins;Core Protein;Critical Pathways;Culicidae;Cytokinesis;Cytoplasm;Cytoskeleton;Data;Daughter;daughter cell;Development;Drug resistance;Ensure;Epitopes;Erythrocytes;Excision;experimental study;falls;fitness;Future;Generations;Genetic;genetic manipulation;Goals;Human;improved;Individual;Infection;Insecticide Resistance;Instruction;knock-down;Knock-out;Knowledge;Label;Lipid Bilayers;Malaria;Measurement;Mediating;member;Membrane;Microscopy;Molecular;Molecular Machines;Morbidity - disease rate;mortality;Motility;new therapeutic target;novel;Organelles;Parasite Control;Parasites;Plasmodium;Plasmodium falciparum;Pregnant Women;Process;protein complex;Proteins;Resolution;Series;Shapes;Signs and Symptoms;Structure;System;Technology;Therapeutic;Time;tool;Toxoplasma gondii;Transgenic Organisms;ultra high resolution;Visualization

PROJECT_TITLE: Spatial, temporal, and functional study of the basal complex in Plasmodium falciparum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE A history of chronic heavy alcohol drinking is a risk factor for memory loss and cognitive decline in older individuals. This research explores cellular mechanisms that involve oligodendrocytes, the myelinating glial cells of the central nervous system, which may contribute to the advancement and exacerbation of cognitive dysfunctions associated with alcohol and aging.

PI_NAMEs: RICHARDSON, HEATHER NOËL (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Ablation;Acceleration;Age;age difference;age related;age related decline;age-related disease;Aging;aging population;aging process;Air;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;animal old age;Axon;Behavior;Behavioral Assay;Birth;Blood alcohol level measurement;Brain;Cell division;Cell Lineage;Cell Physiology;Cells;cellular development;Central Nervous System;Chronic;Clinical;Cognition;cognitive ability;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive task;CSPG4 gene;Data;Dementia;dementia risk;design;Deterioration;Development;Drug Targeting;Ethanol;executive function;Experimental Designs;experimental study;Female;Foundations;frontal lobe;Future;Heavy Drinking;Hippocampus;Human;Impaired cognition;Impairment;juvenile animal;Learning;Length;Link;male;Maps;Memory;Memory Loss;Modeling;molecular scale;mouse model;Mus;Muscarinic Acetylcholine Receptor;Myelin;Myelin Sheath;neural circuit;Neuroglia;nonhuman primate;normal aging;novel;old mice;older adult;Older Population;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Outcome;Patients;pharmacologic;Phenotype;Population;precursor cell;Prefrontal Cortex;prevent;Process;Recording of previous events;Regulation;remyelination;repaired;Reporter;Research;Rest;Risk Factors;Rodent;Role;Series;sex;Sex Differences;Solid;Symptoms;tau Proteins;Technology;Temporal Lobe;Testing;Therapeutic;therapeutic target;Transgenic Organisms;treatment strategy;vapor;Visualization;white matter;Withdrawal;young adult

PROJECT_TITLE: The Role of Oligodendrocytes in Cognitive Decline after Alcohol and Aging

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]