ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: LIU, BO ;SCHWEIZER, MARIN LEIGH (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Acceleration;Address;Area;Attention;career;career development;Clinical;clinical care;Clinical Research;Communities;community engagement;design;Discipline;Dissemination and Implementation;Ecosystem;Eligibility Determination;Ethnic Origin;Ethnic Population;Family;Fostering;Funding;Grant;Guidelines;Health;health equity;improved;Individual;Industry;innovation;Institution;inter-institutional;Journals;Leadership;Life;Measures;member;Mentors;Mentorship;Needs Assessment;Outcome;Participant;Patients;Positioning Attribute;Principal Investigator;Program Evaluation;programs;Publishing;Race;racial population;recruit;Research;research data dissemination;Research Design;Research Personnel;resilience;Science;Scientist;Secure;Strategic Planning;stressor;success;Training;translational pipeline;Translational Research;Universities;Vision;Wisconsin;Woman;Work

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  This proposal focuses on sensitizing pancreatic cancers to immunotherapy by targeting foreign proteins called ‘neoantigens’, which emerge as the cancer grows. Patient’s neoantigens will be identified and targeted by vaccines with a view to trick immune cells to recognize and kill the tumor bearing these neoantigens.

PI_NAMEs: ZAIDI, NEEHA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Advisory Committees;Affect;Algorithms;anti-tumor immune response;Antibodies;Antigen Targeting;antigen-specific T cells;Antitumor Response;Architecture;B-Lymphocytes;Binding;Bioinformatics;Biopsy;Cancer Burden;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;Categories;CD8-Positive T-Lymphocytes;Cell Count;Cell Death;Cell Reprogramming;Cells;Chronic Disease;Clinical;Clinical Trials;Clinical Trials Design;Combination immunotherapy;Complement;CTLA4 gene;cytokine;Data;early phase clinical trial;effector T cell;Environment;Epitope spreading;exhaustion;exome sequencing;FDA approved;Flow Cytometry;Funding;Future;Gene Expression;Genetically Engineered Mouse;Glioblastoma;Goals;Grant;Human;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;immunogenicity;Immunology;Immunotherapy;Infiltration;inhibiting antibody;ipilimumab;KPC model;KRAS2 gene;KRASG12D;Lesion;Ligands;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Melanoma;Memory;Mentorship;monocyte;Mus;mutant;Mutate;Mutation;neoantigen vaccine;neoantigens;neoplastic cell;Nivolumab;nonsynonymous mutation;Normal Cell;novel vaccines;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;participant enrollment;Pathologic;Pathway interactions;Patients;Peptide Vaccines;Peptides;peripheral blood;Phenotype;Point Mutation;pre-clinical;preclinical study;premalignant;prevent;Prevention;programmed cell death ligand 1;programs;Proteins;Reporting;Research Personnel;Resected;Resistance;Resources;response;safety assessment;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Somatic Mutation;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Technology;Testing;TP53 gene;trafficking;transcriptome;transcriptome sequencing;translational oncology;tumor;Tumor Burden;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;tumorigenesis;Up-Regulation;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative  This proposed research aims to leverage novel technology that enables mesoscale neural activity measurements and identify emergent mesoscale features that control the expression of innate (instinctual) behaviors such as aggression, mating, and fear responses. The experience-induced behavioral plasticity observed in these behaviors can lead to mental disorders, including uncontrolled aggression, sex offenses, and generalized anxiety, affecting more than 20% of the human population. The high-resolution studies proposed here will generate novel theories and approaches towards identifying neural substrates that can be targeted to resolve or ameliorate conditions of great scientific, medical and societal significance.

PI_NAMEs: STAGKOURAKIS, STEFANOS  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: activity marker;Address;Affect;Aggressive behavior;Amygdaloid structure;analysis pipeline;Anatomy;Animals;Anterior;Area;Award;Behavior;Behavior Control;behavior influence;behavior prediction;Behavioral;Behavioral Paradigm;behavioral plasticity;Brain;Brain imaging;Brain region;Cell Nucleus;cell type;Chronic;Cognition;cognitive process;Communication;Computer software;conditioned fear;Custom;Data;design;Development;Discipline;Electrophysiology (science);Emotional;Exhibits;experience;experimental study;extracellular;family burden;Female;Financial Hardship;Fluoxetine;FOS gene;Fright;frontier;generalized anxiety;Goals;Grain;Human;Hypothalamic structure;Image;in vivo;insight;Instinct;interest;Investigation;Laboratory mice;Learning;Logic;machine learning method;male;Maps;Measurement;Medical;Mental disorders;Mentors;Methodology;Methods;Molecular;Monitor;Mus;neural;Neurons;Neurosciences;new technology;novel;novel therapeutics;Partner in relationship;Pattern;pharmacologic;Phase;Physiological;Population;predictive modeling;Prefrontal Cortex;Prevalence;programs;Reagent;Research;Resolution;response;Risperidone;Role;segregation;Sex Offenses;Shapes;Silicon;skills;social;Social isolation;Societies;Spatial Distribution;System;Technology;Testing;theories;Therapeutic;therapeutically effective;tool;Training;Vision;Work

PROJECT_TITLE: Towards the identification of a mesoscale neural systems logic underlying innate behaviors


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative We have recently uncovered a novel role for cholinergic basal forebrain glutamatergic neurons in body weight control. This project focuses on elucidating the underlying neurocircuits for the action of glutamatergic neurons in the control feeding and body weight control. Knowledge gained from these studies will provide needed insight into how cholinergic circuits in the central nervous system modulate metabolic and appetitive programs to regulate body weight.

PI_NAMEs: ARENKIEL, BENJAMIN R (contact);TONG, QINGCHUN

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;addiction;Address;Affect;Anatomy;Area;Attention;Award;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;Body Weight;Brain;Brain region;Cardiovascular Diseases;Cause of Death;cell type;Central Nervous System;cholinergic;cholinergic neuron;Chronic;Communication;Data;Desire for food;Diabetes Mellitus;Diagonal Band of Broca;Diet;Diet Habits;Eating;Eating Behavior;Electrophysiology (science);energy balance;experimental study;Fasting;feeding;Feeding behaviors;Food;Food Aversion;food consumption;Genetic;glutamatergic signaling;Glutamates;Goals;Habenula;Healthy Eating;Homeostasis;Hyperphagia;Hypothalamic structure;insight;Knowledge;Lateral;Life;Link;Mediating;Mental Depression;Metabolic;Metabolism;Nature;neural;neuronal circuitry;Neurons;neurotransmission;novel;nutrient metabolism;Obesity;Obesity associated disease;obesity development;optogenetics;Population;programs;Prosencephalon;Research Proposals;Research Support;reward processing;Rewards;Role;Satiation;Sensory;Signal Pathway;Signal Transduction;Starvation;Synapses;Testing;United States;Wakefulness;Weight maintenance regimen;With laterality

PROJECT_TITLE: Genetically Dissecting Chorinergic Signaling in Body Weight Control


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The Academic Leadership Award will provide support for developing a comprehensive statistical training program that includes advanced statistical methods tailored to physicians and scientists in aging research. The K07 award will also enhance research capacity at Indiana University by providing data resources and analytical tools from completed and ongoing aging studies to support secondary data analyses and pilot projects.

PI_NAMEs: GAO, SUJUAN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Adult;Age;age related;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;analytical tool;Archives;Award;Biological Markers;Biometry;Blood;Cardiovascular Diseases;career;Case Study;Clinical Data;Collaborations;comorbidity;Computerized Medical Record;Data;Data Analyses;Data Analytics;Data Collection;data management;data resource;Data Science;Dedications;Development;digital;Dimensions;disability;Disease;Doctor of Philosophy;doctoral student;Educational Curriculum;Epidemiology;epidemiology study;Faculty;Funding;Genetic;Genomics;Goals;Grant;Growth;Health;health data;high dimensionality;imaging facilities;Impaired cognition;Indiana;Individual;Intensive Care Units;interdisciplinary approach;Investments;K-Series Research Career Programs;Leadership;lectures;Longitudinal Studies;Malignant Neoplasms;medical schools;Mentors;Methodology;Modernization;multidisciplinary;multiple omics;Musculoskeletal;Nature;neuroimaging;Neurosciences;next generation;Older Population;Pharmacy facility;Physicians;Pilot Projects;Population;Postdoctoral Fellow;Prevalence;Principal Investigator;Productivity;programs;Public Health;Quality of life;Recovery;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;Scientist;Statistical Methods;statistics;Students;Survivors;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities

PROJECT_TITLE: Academic Leadership Award for Statistical Training in Multidisciplinary Aging Research

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Brain microvascular dysfunction promotes impairments of neurovascular coupling (NVC) leading to cognitive dysfunction that precedes Alzheimer's disease (AD). Mitochondria are cellular energy sensors and our pilot studies observed alteration of cellular bioenergetics in brain microvessels in aged mice and mouse model of AD. Notably, we observed sex dependent alterations of microvascular bioenergetics during aging and in response to peroxynitrite. We propose that sex dependent peroxynitrite activity alters the microvascular bioenergetics leading to impaired NVC and cognitive function in AD. We believe that selectively targeting the peroxynitrite could benefit the sex-dependent microvascular bioenergetics.

PI_NAMEs: KATAKAM, PRASAD V (contact);MOSTANY, RICARDO

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Age;Age Months;age-related disease;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Animals;Antioxidants;awake;Behavioral;Biochemical;Bioenergetics;Biological Assay;Blood Vessels;Brain;C57BL/6 Mouse;Cells;cerebral microvasculature;cerebrovascular;Citric Acid Cycle;cognitive function;comparison control;Dependence;Diabetes Mellitus;discrimination task;Electron Spin Resonance Spectroscopy;enzyme activity;Estrogens;extracellular;Female;Free Radicals;Genus Hippocampus;Glycolysis;high throughput screening;Hormones;Human;Impaired cognition;Impairment;in vivo;Insulin;ischemic injury;Knock-in;male;Measures;Mediating;Metabolic;Methods;Microscopy;Microvascular Dysfunction;Mitochondria;Molecular;molecular targeted therapies;mouse model;Mus;neglect;Neurodegenerative Disorders;neurovascular coupling;neurovascular unit;Nitric Oxide;novel;Obesity;old mice;Oxidative Phosphorylation;Perceptual learning;Peroxonitrite;Physiological;Pilot Projects;Play;Porphyrins;Production;protein expression;Protons;Reactive Oxygen Species;Reporting;Research;Respiration;Respiratory physiology;response;Risk;Role;senescence;sensor;Severities;sex;Sex Differences;Signal Transduction;Stress;Technology;Testing;Texture;therapeutic target;two photon microscopy;two-photon;Vibrissae

PROJECT_TITLE: Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's Disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Data Science;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Our goal is to develop a novel framework for heterogeneous data integration, including new tools for dimension reduction and interpretable machine learning. This framework will be applied to data from three HIV cohort studies (US-UNC, Switzerland, and US-Duke) to reveal relationships between host characteristics and HIV reservoir size, both in the presence and absence of cannabis use.

PI_NAMEs: RUDIN, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Anti-Inflammatory Agents;antiretroviral therapy;Biological;Cannabinoids;Cannabis;CD4 Positive T Lymphocytes;Cells;Characteristics;Clinical;CNR2 gene;cohort;Cohort Studies;Complex;complex data;Computer Models;computerized tools;curse of dimensionality;Data;data integration;Data Set;Decision Trees;Derivation procedure;dimension reduction;Dimensions;drug of abuse;Evaluation;explainable machine learning;Genes;Genetic Transcription;Goals;heterogenous data;high dimensionality;HIV;HIV Infections;Immune;Immune system;immunoregulation;Individual;Inflammation;insight;Integration Host Factors;Interruption;Laboratories;latent HIV reservoir;machine learning framework;machine learning method;machine learning model;marijuana use;Methods;Modeling;multidimensional data;Nature;Neighborhoods;novel;Participant;Pathway interactions;Pattern;Persons;Population;preservation;recreational drug use;Reporting;Residual state;Structure;Switzerland;Techniques;Therapeutic;tool;Training;Universities;usability;viral rebound;Work

PROJECT_TITLE: A machine learning framework for understanding impacts on the HIV latent reservoir size, including drugs of abuse


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project is relevant to public health because food insecurity is highly prevalent and associated with metabolic consequences such as obesity, metabolic syndrome, and chronic diseases such as diabetes. This project is relevant to the NIH’s mission and specifically NIDDK’s mission because the outcome measures of poor diet and metabolic syndrome are known risk factors for poor metabolic health.

PI_NAMEs: TOMIYAMA, A. JANET  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acute;acute stress;Affect;Behavioral;biobehavior;biological adaptation to stress;Biological Assay;Carbohydrates;Censuses;Chronic;Chronic Disease;Clinical;Clinical Research;cohort;Consumption;Country;COVID-19;Data;design;Diabetes Mellitus;Disproportionately impacts women;Eating;Epidemiology;epidemiology study;Exposure to;Fatty acid glycerol esters;Food;food consumption;food insecurity;food security;Future;Goals;Growth;Hair;Health;Health Food;High Prevalence;high risk;high risk population;Hormones;Household;Hydrocortisone;Hyperphagia;hypothalamic-pituitary-adrenal axis;improved;indexing;Individual;Intake;interdisciplinary approach;Intervention;Laboratories;Length;Literature;Measures;Metabolic;Metabolic syndrome;Methods;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Nutritional;Nutritive Value;Obesity;Outcome;Outcome Measure;Pattern;perceived stress;Physiological;Physiology;Policies;policy implication;Population;Prevalence;programs;protective factors;psychologic;Psychology;psychosocial;Public Health;resilience;resilience factor;Resources;Respondent;Risk;Risk Factors;Role;Sampling;screening;social;Socioeconomic Status;Sodium;Stress;stressor;sugar;Testing;Unhealthy Diet;United States Department of Agriculture;United States National Institutes of Health;Update;Woman;Work

PROJECT_TITLE: Food Insecurity, Poor Diet, and Metabolic Syndrome: Cortisol’s Amplifying Role

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Modern medical practice is now relying on the fruits of genomic research for analyzing the genetic makeup of patients and their cancers. New medical treatments are increasingly being tailored to individual patients for increasing their effectiveness and lessening side-effects. We propose to train scientists who will be developing the systems and analysis that will enable greater use of genomic information for biomedical researchers and the general public when they see a doctor.

PI_NAMEs: LU, QIONGSHI  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: genome sciences;Institution;Training

PROJECT_TITLE: Institutional Training in the Genomic Sciences


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative In this proposal, we will characterize the trajectories of outcome in early course psychotic disorders treated in coordinated specialty care programs. We will also identify clinical and biological features, and biological subtypes of psychotic disorders that may help predict outcome.

PI_NAMEs: GERSHON, ELLIOT S (contact);KEEDY, SARAH K

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Accounting;Age Years;Biological;Biological Markers;biomarker development;biomarker identification;biotypes;Bipolar Disorder;Boston;care outcomes;care systems;Categories;Chronic;Clinic;Clinical;clinical practice;clinical predictors;Cognition;Cognitive;cognitive function;Communities;community setting;Coordinated Specialty Care;cost;Data;Data Collection;design;Diagnosis;Diagnostic;Dimensions;Disease remission;early detection biomarkers;Early Intervention;early psychosis;early satiety;Electroencephalography;Enrollment;Eye Movements;follow-up;functional decline;functional outcomes;Funding;Goals;Grant;Heterogeneity;Image;imaging biomarker;Impaired cognition;Impairment;improved;improved outcome;Individual;individual variation;Intervention;Measures;medical specialties;meetings;Modeling;Multivariate Analysis;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neurosciences Research;Onset of illness;Outcome;outcome prediction;Participant;Patients;pharmacologic;Phenotype;phenotypic biomarker;Population;Population Characteristics;prediction algorithm;Predictive Value;Procedures;prognostic value;programs;Psychoses;psychosocial;psychotic;Psychotic Disorders;Recovery;recruit;Resources;response;Sampling;Schizoaffective Disorders;Schizophrenia;Schizophreniform Disorder;Services;Site;Stimulus;Structure;Subgroup;Substance abuse problem;success;Testing;Therapeutic Intervention;therapy resistant;Time;treatment adherence;treatment planning;treatment program;Variant

PROJECT_TITLE: 2/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative  This project will advance an innovative off-the-shelf, translational cell therapy to enhance clearance of apoptotic cells, which would be transformative for the treatment of fibrotic injuries such as volumetric muscle loss and many others. It will also build fundamental knowledge of a completely new approach to macrophage cell therapy enabled by intracellularly acting biomaterials that allow functional control over phenotype and prevention of cell mediated rejection.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Allogenic;Anti-Inflammatory Agents;Apoptotic;Autologous;Behavior;Biocompatible Materials;biodegradable polymer;Cell Therapy;cell type;Cells;Cues;Data;Dexamethasone;Disease;Dose;Drug Delivery Systems;Fibrosis;Flow Cytometry;Gene Expression Profiling;Generations;Goals;high reward;high risk;Histology;Human;Immune;Immune response;improved;In Situ;In Vitro;in vitro testing;in vivo;in vivo Model;Inflammation;Inflammatory;Injury;innovation;Knowledge;limb loss;Macrophage;manufacturing cost;Mechanics;Mediating;Mediator;mouse model;Mus;Muscle;muscle repair;Muscle satellite cell;neutrophil;novel strategies;particle;Patients;Pharmaceutical Preparations;Phenotype;prevent;Prevention;Process;Proliferating;Punch Biopsy;quadriceps muscle;regenerative;Regulatory T-Lymphocyte;response;Series;Site;Skeletal Muscle;Source;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;tissue repair;Tissues;Trauma;uptake;volumetric muscle loss;wound healing

PROJECT_TITLE: Particle-Assisted Control over Macrophage-Neutrophil interactions (Pac-Man)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia;Telehealth

ORG_CITY: LYME

ORG_NAME: SYNCHROHEALTH LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Older adults diagnosed with sarcopenia (e.g., loss of muscle mass, strength, and function) or frailty, are typically prescribed at-home resistance-based exercises to maintain and enhance physical function. Such prescriptions rely on self-report patient compliance to confirm whether the exercises are conducted and whether their exercise fidelity is sufficient to promote functional recovery. Herein, we propose to optimize the BandPass system, a Bluetooth-enabled resistance exercise band, patient app, clinician dashboard, and a cloud-based infrastructure that automatically senses the continuous force exerted during exercises to enable remote monitoring, compliance checking, and exercise classification while helping to overcome the current gaps of clinically tailored home exercise programs.

PI_NAMEs: HALTER, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Accelerometer;Acute;Address;Adherence;Affect;Age;age group;aging in place;Algorithms;American;Bluetooth;Businesses;Calibration;Caring;Cessation of life;Classification;classification algorithm;Clinical;clinically relevant;cloud based;Cognitive;commercialization;Computer software;computing resources;Consumption;cost;Custom;dashboard;Data;Data Collection;data communication;data dashboard;data exchange;Data Science;data visualization;design;Device Designs;Devices;Diagnosis;diaries;disability;disability risk;Distal;Drops;Elasticity;Electronics;evidence base;Exercise;exercise adherence;exercise physiologist;exercise program;exercise training;experience;Feedback;frailty;functional decline;Future;Goals;Hand Strength;handheld mobile device;Health;Healthcare;Home;Hour;Housing;improved;Infrastructure;innovation;Institutionalization;Internet;Interview;Lead;machine learning algorithm;manufacture;Marketing;Measurement;Measures;Medical Device;Methods;mHealth;mobile application;Monitor;monitoring device;Morbidity - disease rate;Motion;muscle form;muscle hypertrophy;muscle regeneration;muscle strength;Muscular Atrophy;Musculoskeletal;Non-Invasive Detection;novel;older adult;operation;Outcome;Pain;Patient Compliance;Patient Monitoring;Patient Monitoring System;patient oriented;Patient Self-Report;Patients;Persons;Phase;Physical Function;Physical Performance;physical therapist;Physicians;Pilot Projects;Positioning Attribute;Predictive Analytics;preservation;Procedures;Production;Quality of life;Recommendation;Recovery;Recovery of Function;Recreation;remote monitoring;remote patient monitoring;remote sensing;Reporting;Research Design;Resistance;resistance exercise;Resolution;Resources;Risk;sarcopenia;satisfaction;Self-Help Devices;sensor;Services;Site;Small Business Technology Transfer Research;Sports;standard care;Structure;success;Surveys;System;Technology;Testing;Time;Training;transmission process;Tube;usability;user centered design;user-friendly;validation studies;Variant;verbal;Vision;Visual;Writing

PROJECT_TITLE: BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Postpartum depressive (PPD) symptoms are common among women following the birth of a child and increase the risk for developmental delays and behavioral problems in children. This research study will test the preliminary effects of a novel social media-based parenting program on measures of responsive parenting and child development among women with PPD. Findings from this research can inform public health interventions targeting women with PPD symptoms.

PI_NAMEs: BOYD, RHONDA C;GUEVARA, JAMES P (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Age Months;Birth;Caring;Child;Child Care;Child Development;Child Language;Child Rearing;Cognitive;cognitive development;common symptom;Competence;depressive symptoms;Development;Developmental Delay Disorders;effectiveness testing;effectiveness trial;Eligibility Determination;Emotional;ethnic diversity;evidence base;experience;follow-up;Future;Goals;Hybrids;improved;Infant;Knowledge;Language;Measures;Mediating;Mediator;Mental Depression;Mothers;novel;Outcome;parenting intervention;Pediatric Hospitals;Persons;Phase;Pilot Projects;Postpartum Depression;Postpartum Period;Poverty;primary care practice;Problem behavior;programs;public health intervention;racial diversity;Randomized;Research;research study;Risk;scale up;Signal Transduction;skills;social media;Social support;Testing;treatment effect;treatment program;urban children;Woman

PROJECT_TITLE: Social Media-Based Parenting Program for Women with Postpartum Depressive Symptoms


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Women's Health Research


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Patients with hearing impairment and central neurological disorders have difficulty keeping track of speech and other complex sounds, particularly in challenging noisy environments. We seek to understand how populations of neurons in auditory cortex change their activity as the brain adapts to noisy environments. These experiments will provide insight into basic function of the healthy brain that can inform treatment of hearing disorders.

PI_NAMEs: DAVID, STEPHEN V (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Anatomy;Animals;Area;Arousal;Attention;Auditory;Auditory area;Auditory Perception;Auditory Perceptual Disorders;auditory processing;auditory stimulus;Auditory system;Behavior;Behavioral;Brain;Categories;cell type;Code;Cognitive;cognitive function;cognitive process;Compensation;Complex;Computer Models;Crowding;Data;deep neural network;density;Dimensions;Discrimination;Dissociation;Electrophysiology (science);Enhancers;Environment;excitatory neuron;experimental study;Ferrets;flexibility;Frequencies;frontal lobe;Hearing;hearing impairment;Hearing problem;Human;improved;indexing;Individual;inhibitory neuron;insight;Interneurons;Label;Lasers;Learning;Life;Link;Machine Learning;machine learning method;Masks;Measures;Mediating;Methods;Microelectrodes;Modeling;Monitor;Nervous System Disorder;neural;neural model;neuromechanism;Neurons;neurophysiology;new technology;Noise;normal hearing;novel;optogenetics;Patients;Performance;Peripheral;Play;Population;Process;Property;Pupil;receptive field;Reporting;Rewards;Role;Sensory;Shapes;Signal Transduction;sound;Source;Speech;Stimulus;Testing;Time;tool;Training;Virus

PROJECT_TITLE: Sound encoding by neural populations in auditory cortex during behavior

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  Viruses and host are locked in an evolutionary conflict, yet our understanding of host defenses that restrict viral replication and viral countermeasures are poorly understood. This knowledge gap is driven primarily by host factors being redundant in host genomes and the efficient inactivation of these pathways by successful viruses. We overcome these obstacles to identify new virus-host interfaces and to define their function in host defense and in cellular physiology.

PI_NAMEs: ORCHARD, ROBERT C. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Area;Attenuated;Binding;Biochemical;Biology;Bypass;Cell Physiology;Communicable Diseases;comparative;Complex;Complication;Conflict (Psychology);Disparate;Epigenetic Process;Family;gain of function;Genes;Genetic;Genetic Screening;Genome;Histone Acetylation;Host Defense;Immune Evasion;Infection;Influenza;insight;Integration Host Factors;Knowledge;Ligands;Maps;Molecular;Mus;Mutation;Norovirus;Orphan;pathogen;Pathway interactions;Physiological;programs;Protein Family;protein function;Proteins;receptor;screening;System;tool;Viral;Viral Genes;Virulent;Virus;Virus Replication

PROJECT_TITLE: Overcoming host Genetic Redundancy and Pathogen Subversion to Define new host-viral Interfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Cellular senescence, a biological response to exposure to stress, including chemotherapy, is believed to prevent cancer progression. However, some phenotypes associated with cellular senescence, including invasion and metastasis, result in cancer progression. We propose test the investigate how senescence promotes cancer progression, and to identify novel therapeutic means to prevent breast cancer progression following exposure to chemotherapy.

PI_NAMEs: DAVID, GREGORY  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Adjuvant;Adverse effects;Affect;aggressive breast cancer;angiogenesis;Binding;Biological;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;cancer cell;cancer therapy;Cell Aging;Cell Cycle;Cell model;Cell Survival;Cells;chemokine;chemotherapy;Circulation;cytokine;cytotoxic;Cytotoxic Chemotherapy;Data;Development;Disease;DNA Damage;effective therapy;epithelial to mesenchymal transition;Exposure to;extracellular;Flagellin;Genetic;Genotoxic Stress;genotoxicity;Goals;HMGB1 gene;Human;IL-6 inhibitor;IL8 gene;In Vitro;Inflammatory;Inflammatory Response;Interleukin-6;Invaded;Light;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metalloproteases;Metastasis Induction;metastatic process;migration;Modeling;Molecular;mouse model;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;pharmacologic;Phenotype;prevent;Primary Neoplasm;Production;programs;Proliferating;Property;Radiation therapy;Relapse;response;Sampling;senescence;senescence associated secretory phenotype;senescent cell;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;standard care;Stress;Testing;Therapeutic;therapeutic target;TLR5 gene;Toll-like receptors;trait;tumor;Tumor Burden;tumor microenvironment;tumor progression;Withholding Treatment;Woman

PROJECT_TITLE: Targeting the HMGB1-TLR5 pathway to prevent senescence-induced metastasis in breast cancer.


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Microbiome

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative We propose to study the mechanisms contributing to immunological non-response to antiretroviral therapy (cART) in HIV-1 infected subjects by defining the bidirectional interaction between the gut microbiome and gut immune cells, in particular B cells. Specifically, we will dissect the clonal architecture and bacterial reactivity of intestinal IgA1 and IgA2 responses and their functional crosstalk with a) the gut microbiome; b) other elements of the mucosal immune system; and c) measures of viral persistence in the gut mucosa before and during cART.

PI_NAMEs: CERUTTI, ANDREA ;FAITH, JEREMIAH JAMES;MEHANDRU, SAURABH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: 3-Dimensional;antiretroviral therapy;Architecture;Automobile Driving;B-Lymphocytes;Bacteroides;Biological Assay;Biology;Blood;Cell Communication;Cell Ontogeny;Cells;cohort;commensal bacteria;community setting;Disease;Disease Outcome;Dissection;DNA;dysbiosis;Elements;epithelial injury;experience;Faith;fecal microbiome;fecal microbiota;Feedback;Flow Cytometry;Gastroenterologist;gastrointestinal;Gastrointestinal tract structure;Germ-Free;Gnotobiotic;Goals;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Gut Mucosa;healthy volunteer;HIV;HIV-1;host microbiota;IgA1;IgA2;Immune;immune function;immune reconstitution;Immune response;Immune system;Immunofluorescence Microscopy;Immunoglobulin A;Immunohistochemistry;Immunologics;Impairment;Individual;Infection;Inflammation;Inflammatory;insight;Interleukin-6;International;Interruption;intestinal epithelium;intestinal fatty acid binding protein;Intestines;Lesion;Longitudinal Studies;Measures;medical schools;member;Metagenomics;Methodology;Methods;microbial;microbial community;microbiome;microbiome research;microbiota;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;novel;Pathogenesis;patient subsets;Patients;Penetrance;Phenotype;Physiological;Population;Production;programs;Property;recruit;Regulation;Research;Research Personnel;resident commensals;response;Seminal;Serum;Signal Transduction;synergism;Testing;Therapeutic;Tissues;TNF gene;Training;Viral;Viral Pathogenesis;Viral reservoir;viral RNA;Virion;Virus Replication

PROJECT_TITLE: Decoding mutualistic microbiota-B cell interactions in the HIV-1-infected gut: impact on immunological non-responders


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MEMPHIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Project Narrative The computational enzyme modeling community is continuously seeking resources for a better understanding of enzyme structure, function and enzymatic reaction pathways, which will greatly advance drug design and enzyme bioengineering. Artificial Intelligence will be employed to facilitate computational modeling of two enzyme systems: 1) Chorismate mutase enzymes, which catalyze pericyclic rearrangement reactions to produce aromatic amino acids in bacteria, are a potential target for designing antibiotics; and 2) Cytochrome P450 which is a superfamily of enzymes that play key roles in the metabolism of drugs and other xenobiotics. Rigorous and automated quantum mechanics and molecular mechanics (QM/MM) and QM-clustering modeling design will be generated by data mining and machine learning techniques from existing and appreciative knowledge; and the output of this project will be systematic and well-formatted data as well as data mining and machine learning models which can generate computational protocol of these two enzymes, which potentially can be transferred to the study of other enzyme systems.

PI_NAMEs: CHENG, QIANYI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: antibiotic design;Aromatic Amino Acids;Artificial Intelligence;Bacteria;Biochemical Reaction;Biomedical Engineering;Case Study;Chorismate Mutase;Communities;Computer Models;Computing Methodologies;Cytochrome P450;data format;data mining;Development;Drug Design;drug discovery;drug metabolism;enzyme model;enzyme structure;Enzymes;Future;Goals;innovation;insight;Knowledge;Machine Learning;machine learning method;machine learning model;metalloenzyme;Methodology;Methods;model design;Modeling;molecular mechanics;Output;Pathway interactions;Play;protein structure prediction;Proteins;Protocols documentation;protonation;Publishing;Quantum Mechanics;Reaction;Research;Resources;Series;simulation;System;Techniques;Work;Xenobiotics

PROJECT_TITLE: Data Mining and Machine Learning Guided QM/MM and QM-Cluster Modeling of Enzymatic Reactions


ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE While chemists have made great progress in the ability to synthesize important molecules for biomedical applications, there are many useful transformations that remain impossible using current methods. Here we take cues from nature's expert use of hydrogen atom transfer (HAT) to deliver two new of these aspirational reactions, modular radical hydrogenation and transpositional functionalization. We anticipate that these catalytic chemical transformations will unlock the ability to make previously-inaccessible bioactive molecules and make an impact on human health.

PI_NAMEs: WEST, JULIAN G (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Frontiers in Chemical Reactivity Via Catalytic Hydrogen Atom Transfer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Groundbreaking research and discovery in the life sciences in the 21st century are more interdisciplinary than ever. To expedite scientific advances in the “omics” era, it is critical to train the next generation of quantitative health science students who are strong in statistical genetics and genomics, computational biology, big data computing, reproducible research, with good knowledge in molecular biology, genetic epidemiology and genomic medicine, and who have strong skills in communication, grant and paper writing, teamwork, collaboration, and leadership.

PI_NAMEs: HUTTENHOWER, CURTIS ;LIN, XIHONG  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Interdisciplinary training: Statistical Genetics/Genomics and Computational Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Rural Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Clinical research comes in many different shapes and sizes, and a robust trial innovation network must accommodate all trial types, which no single organization can do alone. Our TIC will be Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC). Led by Drs. Gordon Bernard, Wesley Self, and Christopher Lindsell, each seasoned in leading and collaborating with multisite clinical trial networks, we will embrace and draw on diverse expertise from 6 CTSA-aligned coordinating centers, the national Biostatistics, Epidemiology, and Research Design (BERD) group, health equity experts, and Historically Black Colleges and Universities (HBCUs) to build, test, and share new resources that will enhance and accelerate rigorous, reproducible research and improve human health.

PI_NAMEs: BERNARD, GORDON RAPHAEL (contact);CASEY, JONATHAN DALE;LINDSELL, CHRISTOPHER J.

PROGRAM_OFFICER_NAME: WILEY, KENNETH L

PROJECT_TERMS: Acceleration;Adopted;Adoption;Agreement;biobank;Biometry;Budgets;Businesses;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;cohort;Collaborations;community engagement;Compensation;Complex;Contracts;cost;Data;Data Collection;Data Coordinating Center;data management;data standards;Disease;Doctor of Philosophy;Elasticity;electronic consent;Electronic Health Record;Electronics;Ensure;Epidemiology;Funding;Growth;Health;health care delivery;health equity;Historically Black Colleges and Universities;Human;Image;improved;Infrastructure;innovation;Institution;Institutional Review Boards;interest;Learning;meetings;Methodology;Methods;Monitor;Multi-Institutional Clinical Trial;multi-site trial;novel;Participant;Phenotype;Population;practice-based research network;Procedures;Process;Productivity;programs;randomized, clinical trials;Readiness;Recording of previous events;recruit;Reporting;Reproducibility;Research;Research Design;Resources;Risk;Rural;Seasons;Services;Shapes;Site;Structure;support tools;System;Testing;Time;tool;Touch sensation;Training;trial design;Trust;virtual;Work


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Three-dimensional (3D) chromatin organization (chromatin interactome) plays a critical role in genome function and gene regulation. In this R35 grant application, I will develop model-based methods for imputing and normalizing chromatin chromatins at single cell resolution, identifying cell-type-specific long-range chromatin interactions, and predicting putative target genes of GWAS variants associated with complex human diseases and traits.

PI_NAMEs: HU, MING  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: 3-Dimensional;Applications Grants;Biological Assay;Cell Line;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;chromosome conformation capture;CISH gene;Complex;Computing Methodologies;Data;deep learning;Disease;falls;Gene Expression;Gene Expression Regulation;Genes;Genome;genome wide association study;genome-wide;Hi-C;human disease;Hybrids;In Situ;mammalian genome;Methodology;Methods;Modeling;multimodality;Play;Regulatory Element;Research;Resolution;Role;single cell technology;Systematic Bias;Technology;Tissues;tool;trait;user friendly software;user-friendly;Variant

PROJECT_TITLE: Model-based methods for single cell chromatin interactomic data


NIH_SPENDING_CATS: Aging;Clinical Research;Complementary and Integrative Health;Nutrition;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Sarcopenia

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PROJECT NARRATIVE and Relevance to Public Health Our proposed work will estimate total body creatine pool size by D3-creatine dilution, a novel and previously validated method that provides a direct and accurate estimate of total muscle mass from a single, fasting urine sample. Our objective is to measure total muscle mass (via the D3-creatine dilution method) in the Framingham Heart Study (FHS) and determine its association with genetic and non-genetic risk factors, and their relation with falls, injurious falls and fractures in two large, community-based cohort of older adults, FHS and the Osteoporotic Fractures in Men (MrOS) Study, thus providing new and important public health insights.

PI_NAMEs: KIEL, DOUGLAS P. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Accelerometer;Age;age related;age-related muscle loss;Animals;Attenuated;Belief;Branched-Chain Amino Acids;Clinical;cohort;Cohort Studies;Communities;Creatine;Data;Diet;Dietary Proteins;disability;Dose;Dual-Energy X-Ray Absorptiometry;Essential Amino Acids;Excess Mortality;fall injury;falls;Fasting;Fracture;Framingham Heart Study;Genetic;genetic predictors;genetic variant;genome wide association study;Genotype;Goals;Health Care Costs;Image;imaging modality;Impairment;Inflammation;inflammatory marker;Ingestion;insight;instrument;Interleukin-6;Intervention;late life;Life Style;Measurement;Measures;Mediating;men;Mendelian randomization;Methods;Modeling;modifiable risk;Morphologic artifacts;muscle form;Muscular Atrophy;N-3 polyunsaturated fatty acid;non-genetic;novel;Nutritional;older adult;older men;older women;osteoporosis with pathological fracture;Outcome;Participant;Pathway interactions;Pharmaceutical Preparations;Physical activity;Physical Function;Plants;prevent;preventive intervention;Process;protein intake;Public Health;Publishing;reduced muscle mass;Research;Rest;Risk;Risk Factors;Sample Size;Sampling;skeletal muscle wasting;Specimen;systemic inflammatory response;Techniques;Technology;Testing;therapy development;Thinness;Tissues;Urine;Work

PROJECT_TITLE: Determinants and Outcomes of Age-related Muscle Loss

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This program will provide pediatric oncology trainees with advanced training in the conceptualization, design, and execution of rigorous and reproducible research that will help advance the field and lead to improved outcomes for children with cancer.

PI_NAMEs: LAWLOR, ELIZABETH R;MESHINCHI, SOHEIL  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Pediatric Oncology;Research Training;Training Programs

PROJECT_TITLE: Pediatric Oncology Research Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: NARRATIVE Minimally invasive surgeons are limited to a surface view of the intraoperative field as provided by real- time video. By adding ultrasound, this project will develop a new augmented reality visualization technology that will allow surgeons to see hidden structures such as tumors and blood vessels below the organ surfaces. The anticipated clinical benefits of augmented reality visualization are shorten procedure times, fewer complications, reduced blood loss, and expanded use of minimally invasive surgeries.

PI_NAMEs: SHEKHAR, RAJ  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Ablation;ablative procedure;Adoption;Algorithms;Anatomy;Area;Augmented Reality;Blood Vessels;Calibration;Child;Clinical;clinical translation;cognitive load;Collaborations;Commercial grade;Computer software;Computer Vision Systems;computerized;Custom;data fusion;design;Development;Devices;Educational process of instructing;Electromagnetics;experience;eye hand coordination;Family suidae;Feedback;Future;Goals;Hemorrhage;Hospitals;Human;Hybrids;Image;image registration;improved;industry partner;innovation;Intuition;Laparoscopes;Laparoscopy;Liver neoplasms;manufacture;minimally invasive;Modality;Needles;novel;Operating Rooms;Operative Surgical Procedures;Organ;Pathologic;Performance;preclinical evaluation;Preclinical Testing;Procedures;prototype;Provider;Psyche structure;Reporting;Research;research and development;Running;Safety;sensor;Source;spatial relationship;Structure;Surface;Surgeon;System;Technology;Testing;Thermal Ablation Therapy;Time;Transducers;tumor;Ultrasonic Transducer;ultrasound;usability;Vision;Visualization;Work

PROJECT_TITLE: A clinical platform for ultrasound-augmented laparoscopy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE People with serious mental illness are grossly overrepresented in populations experiencing incarceration and homelessness, representing the culmination of health inequities and unmet mental health and social needs. This mixed methods K23 proposal aims to address important gaps in our understanding of the effects of incarceration on homelessness and downstream mental health and social service use by quantitative analysis of an existing linked administrative database, archival research, and direct ethnographic observations of individuals with SMI in jail. The proposed research responds to NIMH Strategic Priority 4 by strengthening the public health impact of NIMH supported research, particularly Priorities 4.1, 4.2, and 4.4, and the NIMH Division of Services and Intervention Research area of high priority to “Identify new targets for innovative intervention (development/refinement) and service delivery models through research that examines the burdens from mental illness as well as the current use, benefits, safety, costs, and unmet needs for mental health care.”

PI_NAMEs: CASTILLO, ENRICO GUANZON (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;administrative database;Administrator;Area;care coordination;care systems;career;career development;Collaborations;cost;Country;County;Criminal Justice;Data;data infrastructure;Data Set;delivery vehicle;design;Development;Discharge Plannings;Elements;Ensure;Ethnography;evidence base;experience;Failure;Future;Goals;Health;health care service;health inequalities;Health Planning;Health Resources;health service use;Health Services;Health Services Research;Health system;Health trends;Healthcare;high risk;Homeless persons;Homelessness;Hospitalization;Hospitals;Housing;Imprisonment;improved;Individual;Inequity;innovation;Institution;Institutional Policy;Intervention;Intervention Studies;Jail;Justice;Knowledge;Laws;Link;Los Angeles;medically underserved;Mental disorders;Mental Health;Mental Health Services;mental representation;Mentors;Methods;Modeling;National Institute of Mental Health;Outcome;Pattern;Persons;Policies;Policy Maker;Population;prevent;Prisoner;Prisons;programs;psychological distress;Public Health;Public Sector;Qualitative Research;Quality of Care;recidivism;reincarceration;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Risk;Safety;Service delivery model;Services;severe mental illness;Site;skills;social;Social outcome;Social Work;Subgroup;System;Testing;therapy design;Translations;trend;underserved community;Vulnerable Populations

PROJECT_TITLE: The Jail-to-Homelessness Pipeline and Serious Mental Illness

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Genomic testing has become integrated into cancer care and physicians routinely order tumor sequencing analyzing hundreds of genes to identify options for personalized treatment. As almost every physician will treat patients with cancer or cancer survivors and assist in cancer prevention and risk assessment, all require some knowledge of cancer genomics. Education beginning in medical school and continuing through training is needed to allow physicians to appropriately utilize genomic test results in the care of patients.

PI_NAMEs: HASPEL, RICHARD L (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: actionable mutation;American Society of Clinical Oncology;Applied Genetics;cancer care;Cancer Education Grant Program;cancer genomics;cancer prevention;cancer risk;Cancer Survivor;care providers;clinical care;Clinical Oncology;Clinical Pathology;clinically actionable;Development;Education;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;efficacy evaluation;Ensure;Evaluation;Fellowship Program;Funding;Future;Genes;Genetic;genomic data;Genomics;Goals;Grant;handbook;improved;innovation;International;Knowledge;Learning;Malignant Neoplasms;Medical Oncology;medical schools;Medical Students;meetings;member;Modeling;novel;Oncologist;Oncology;online community;online resource;Participant;Pathologist;Pathology;Patient Care;Patients;personalized medicine;Physicians;Play;Process;programs;Publications;Reporting;resilience;Risk Assessment;Services;Site;skills;Specimen;Structure;Test Result;Testing;Trainers Training;Training;Training Programs;tumor;undergraduate student;Update;web site;Work;working group

PROJECT_TITLE: A National Curriculum in Cancer Genomics for Physicians and Medical Students


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Kidney Disease;Microbiome;Pediatric;Polycystic Kidney Disease;Prevention;Urologic Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Kidney stone disease is increasingly common, causes significant co-morbidities and has a vast economic impact in adult patients with autosomal dominant polycystic kidney disease (ADPKD). Our preliminary data indicates that kidney stone disease may increase the rate of ADPKD progression. Based on this finding we will address the link between kidney stones and disease severity in ADPKD, and investigate whether frequent use of antibiotics poses a risk for kidney stone disease in individuals with ADPKD.

PI_NAMEs: CHONCHOL, MICHEL BENJAMIN (contact);GITOMER, BERENICE YOLANDE

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Adult;Affect;Age;Antibiotic Therapy;Antibiotics;Automobile Driving;Autosomal Dominant Polycystic Kidney;Bacteria;Biochemical;Cessation of life;Chemistry;Clinical;Clinical Data;Clinical Trials;cohort;comorbidity;Cyst;Data;Data Analytics;Database Management Systems;Databases;Development;Diagnosis;Disease;Disease Progression;disorder prevention;dysbiosis;economic impact;End stage renal failure;experience;Exposure to;Family;Feces;Fibrosis;Future;Gene Mutation;Germ Lines;Goals;Growth;gut dysbiosis;gut microbiome;Healthcare;Healthcare Systems;high dimensionality;Human;Incidence;Individual;Infection;Inflammation;inflammatory marker;Inflammatory Response;Injury;Injury to Kidney;insight;Interleukin-6;Intestines;Kidney;Kidney Calculi;Kidney Diseases;Link;Measures;Medical;member;Metabolic Pathway;metabolomics;microbiome;National Institute of Diabetes and Digestive and Kidney Diseases;Nested Case-Control Study;new therapeutic target;novel;novel therapeutics;Oral;Oxalates;Participant;Patients;Pharmacy facility;Play;Population;prevent;Prevention;Randomized, Controlled Trials;recruit;Renal function;Renin-Angiotensin-Aldosterone System;Resources;Risk;Risk Factors;Role;Sampling;Secondary to;Severity of illness;sex;Testing;Time;transcriptomics;Tubular formation;urinary;Urinary tract;Urine

PROJECT_TITLE: Kidney Stone Disease In ADPKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The current study will determine the role of infant autonomic regulation of attention in the unfolding of autism spectrum disorder (ASD). This work will inform developmental models of ASD wherein disrupted autonomic regulation of attention has proximal effects on real-world interactions that may interfere with learning and have cascading effects on long-term outcomes. Findings will lead to new models for earlier intervention that enrich early experiences and enhance learning opportunities from the first months of life, ultimately improving lifelong outcomes for individuals with ASD.

PI_NAMEs: BRADSHAW, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 3 year old;Age;alertness;Arousal;Attention;Attenuated;autism spectrum disorder;autism symptoms;autistic children;Autonomic nervous system;Behavior;Behavioral;Biological;Biological Markers;Biological Process;biomarker discovery;Birth;Child;comparison group;Control Groups;cost effective;critical period;Data;Deceleration;design;Development;Developmental Process;Diagnosis;early experience;Early identification;Early Intervention;Environment;experience;flexibility;Functional disorder;General Population;Goals;Heart;Heart Rate;improved;individuals with autism spectrum disorder;infancy;Infant;innovation;Knowledge;Lead;Learning;Life;Machine Learning;Measures;model of autism spectrum disorder;Modeling;Neonatal;neonatal period;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Outcome;predictive marker;Premature Infant;rate of change;Regulation;Research;Research Design;response;Role;Siblings;Specificity;Stimulus;Symptoms;System;Techniques;Testing;Time;translational potential;Visual attention;Work

PROJECT_TITLE: The Role of Autonomic Regulation of Attention in the Emergence of ASD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE This project’s goals are to identify, characterize, and quantify CCR5 subsets preferentially used by HIV transmitted founder viruses. The purpose of the study is to facilitate the development of more effective CCR5 targeting drugs and prevention methods.

PI_NAMEs: HEREDIA, ALONSO  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: 3-Dimensional;Address;Affinity;AIDS prevention;Amino Acid Sequence;antagonist;Anti-Retroviral Agents;Binding;CCR5 gene;CD4 Positive T Lymphocytes;Cell surface;cell type;Cells;Characteristics;chemokine;chronic infection;Comparative Study;Data;Data Set;detection sensitivity;Development;Dimerization;Down-Regulation;Drug Targeting;Early Diagnosis;env Gene Products;Environment;experimental study;Exposure to;Fluorescence Resonance Energy Transfer;Genotype;Goals;GTP-Binding Proteins;HIV;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;Human;humanized mouse;imaging approach;imaging modality;immunoreactivity;In Situ;In Vitro;in vivo;Individual;Infection;innovation;Intervention;Knowledge;Ligands;Link;Lymphocyte;Macrophage;Measures;Mediating;Membrane;Methods;Molecular;Monoclonal Antibodies;monocyte;mutant;Nature;nef Protein;Open Reading Frames;optical imaging;Phenotype;Population;pressure;prevent;Prevention;Productivity;Proteins;Reagent;receptor;Receptor Signaling;Recycling;Reporting;Resistance;Resolution;Role;Signal Transduction;simian human immunodeficiency virus;SIV;Sorting;Structure;Sulfate;superresolution imaging;Surface;Testing;Translating;transmission process;ultra high resolution;Vaccine Design;Viral Genes;Viral Proteins;Virus;Virus Diseases;virus envelope;Virus Replication

PROJECT_TITLE: CCR5 determinants for the HIV transmitted founder phenotype

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Dental, Oral, and Craniofacial Disease;Hearing Loss;Neurosciences;Regenerative Medicine;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of the MORE program is to provide research training fellowships to medical students and otolaryngology residents in the NIDCD mission areas of hearing, voice, communication disorders, taste, smell, balance, and head and neck oncology. The long term goal is to develop the next generation of clinician-scientists in otolaryngology, who can both treat patients with these disorders as well as advance the science in ways to improve the health and well-being of future generations of patients.

PI_NAMEs: CORFAS, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 3D Print;Advocacy;Anesthesiology;Appointment;Area;Basic Science;Biology;Biomedical Engineering;Biomedical Research;Biometry;career;career development;Caring;Cellular biology;Clinical;Clinical and Translational Science Awards;Clinical Research;Cochlear Implants;collaborative environment;Communication;Communication impairment;Core Facility;deaf;Dedications;design;Development;Discipline;Disease;Education;education research;Engineering;Environment;Equilibrium;Evaluation;evidence base;experience;Extramural Activities;Faculty;Family Practice;Fellowship;Fostering;Funding;Future Generations;Goals;Grant;hard of hearing;Head and Neck Cancer;Head and neck structure;Head and Neck Surgery;Health;health literacy;Health Services;Healthcare;Hearing;hearing impairment;hearing restoration;Human Genetics;Image;improved;Infrastructure;Institution;Interdisciplinary Study;interest;Internal Medicine;International;Investments;Laboratories;Language;Manuscripts;Measures;Mechanics;Medical;Medical Students;member;Mentors;Michigan;Mission;Molecular and Cellular Biology;National Institute on Deafness and Other Communication Disorders;Nerve Regeneration;Neurology;next generation;Oncology;Operative Surgical Procedures;Otolaryngologist;Otolaryngology;Patient Care;Patients;Pediatrics;Personal Satisfaction;Physicians;Play;Positioning Attribute;pre-doctoral;precision oncology;Process;programs;Psychiatry;Psychology;Recording of previous events;recruit;Research;Research Ethics;Research Institute;Research Methodology;Research Personnel;Research Proposals;Research Training;Residencies;Resources;Role;Rotation;satisfaction;Science;Scientist;skills;Smell Perception;Speech;Structure;Surgeon;symposium;Talents;Taste Perception;Techniques;Tissue Engineering;Training;training opportunity;Training Programs;translational potential;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Voice

PROJECT_TITLE: Michigan Otolaryngology Research Education (MORE)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This application’s long-term goal is to generate novel, efficacious strategies to combat challenging to treat multi-resistant bacterial infections. This study focuses on elucidating complex inter- and intraspecies bacterial interactions to uncover crucial insights about mechanisms bacteria use to synergize and compete in a human-like environment. These interactions using human-relevant microenvironments have not been addressed before.

PI_NAMEs: RAHME, LAURENCE G (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Address;antagonist;Antibiotic Resistance;antibiotic tolerance;Antibiotics;antimicrobial;Architecture;Bacteria;Bacterial DNA;Bacterial Infections;bacterial resistance;bactericide;Cells;Chronic;Clinical;clinically relevant;Collection;combat;Communication;Communities;Complex;cytokine;Disease Progression;dysbiosis;Environment;ESKAPE pathogens;Feces;fighting;Frequencies;Gene Mutation;Goals;gut microbiota;health care settings;Healthcare;Homeostasis;host-associated microbial communities;Human;Immune;Immunofluorescence Immunologic;Immunologics;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;inhibitor;insight;Intestinal permeability;Investigation;Lead;Lung;Metabolic;Microbe;Microbial Biofilms;microbial community;microbial homeostasis;microbiota;microbiota composition;microorganism interaction;Modeling;Molecular;Monitor;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;mutant;Mutation;novel;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;preservation;pressure;Proliferating;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;quorum sensing;Regulation;Relapse;Resistance;Resistance development;Role;Severities;Signal Transduction;small molecule;Stains;synergism;System;Systemic infection;Therapeutic;Time;Trachea;traditional therapy;Transcriptional Regulation;transcriptome sequencing;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: A comprehensive investigation of Pseudomonas quorum sensing regulatory relationships and the consequences on quorum sensing inhibitors in complex communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative  The proposed study is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. We have developed a new remotely-delivered intervention combining targeted cognitive training exercises and group support to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

PI_NAMEs: CARRION, RICARDO ;CORNBLATT, BARBARA A. (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 20 year old;active control;Adolescent;Adolescent and Young Adult;Adopted;Adult;Aftercare;Age;Antipsychotic Agents;Architecture;arm;Attenuated;Behavior;Brain;Child;Clinical;clinical heterogeneity;clinical high risk for psychosis;Cognition;Cognitive;cognitive change;Cognitive deficits;Cognitive remediation;cognitive system;cognitive training;computer game;Consensus;Data;design;Disease;Distal;Dose;Dropout;Early Intervention;Environment;Etiology;Exercise;Future;high risk;high risk population;high-risk adolescents;Hour;Impairment;improved;improved outcome;Individual;information processing;innovation;interest;Internet;Intervention;Lead;MATRICS Consensus Cognitive Battery;Measures;Mental disorders;Modeling;Motivation;National Institute of Mental Health;Neurocognitive;Neuropsychology;Noise;novel;novel strategies;Outcome;Participant;Patients;Performance;pharmacologic;Phase;Pilot Projects;Prevention;Prevention Research;Preventive;processing speed;Psychoses;psychosis risk;psychosocial;Psychotic Disorders;Randomized;remediation;remote delivery;Reporting;Research;Resistance;Risk;Running;Sampling;Schizophrenia;schizophrenia risk;Signal Transduction;Social Functioning;Social Interaction;Speed;Structure;study population;Support Groups;Symptoms;Teenagers;Testing;Thinking;Time;Training;Youth

PROJECT_TITLE: Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE. New methods are needed to kill the deadly antibiotic-resistant opportunistic pathogen, Pseudomonas aeruginosa. R-pyocins are a group of lytic antimicrobials that target the outer lipopolysaccharide core and have been shown to be effective at killing susceptible P. aeruginosa isolates under laboratory conditions, however whether resistant isolates might be similarly susceptible under conditions that more accurately mimic those ongoing during infection is not known. We propose to test the R-pyocin susceptibility of a panel of P. aeruginosa isolates under conditions relevant to the cystic fibrosis lung environment and in an acute murine respiratory model of infection to provide the much-needed justification for further consideration of R-pyocins as potential antibacterial agents to treat P. aeruginosa infections.

PI_NAMEs: GOLDBERG, JOANNA B (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acute;acute infection;Acute Pneumonia;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Award;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;bacteriocin;Bacteriophages;Binding;Biological Assay;Cessation of life;Chemicals;Chronic;chronic infection;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis sputum;Development;efficacy testing;Environment;Gene Expression;Genetic Materials;Goals;Grant;Growth;Head;hospital care;Hour;improved;In Vitro;in vivo;Individual;Infection;Laboratories;Life;Lipopolysaccharides;Lung;Lung infections;Lytic;Methods;Modeling;mouse model;Multi-Drug Resistance;Mus;Nosocomial Infections;Nosocomial pneumonia;novel therapeutics;Nucleic Acids;Nutritional;O Antigens;opportunistic pathogen;pathogen;pathogenic bacteria;Patients;Pneumonia;pneumonia model;Predisposition;priority pathogen;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Pulmonary Cystic Fibrosis;Reporting;Research Personnel;Research Project Grants;Resistance;resistance gene;respiratory;Serotyping;Site;Spottings;Structure;Tail;Testing;Therapeutic;Therapeutic Agents;Translating;United States National Institutes of Health;validation studies;virulence gene

PROJECT_TITLE: Pyocins as antibacterials to treat Pseudomonas aeruginosa infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Lupus;Rheumatoid Arthritis

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE. More than 20% of all Americans suffer from an autoimmune disease, like Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE). Tissue and organ damage in these diseases are caused by cells of the immune system, which produce inflammatory mediators, and antibodies, which recognize and bind to self-tissues. The immediate goal of this proposal is to understand how B lymphocytes are activated to produce destructive antibodies with the long-term goal of identifying new therapeutics that can block production of these destructive antibodies in autoimmune patients.

PI_NAMEs: LUND, FRANCES E. (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Activated B-Lymphocyte;Address;Adjuvant;Affect;American;Antibodies;Antibody Response;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Models;Cell Differentiation process;Cells;Chromatin;Clinical;cytokine;Data;Dependence;Development;directed differentiation;Disease;Effector Cell;epigenome;experimental study;FDA approved;Financial Hardship;Future;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Health;Human;Immune response;Immune system;Immunoglobulin-Secreting Cells;Individual;Inflammation Mediators;Inflammatory;inhibitor;Interferon alpha;Interferon Type II;Interferons;Interleukin-2;interleukin-21;Intervention;IRF1 gene;JAK1 gene;Knowledge;Learning;Licensing;Ligands;Maintenance;Mediating;Mediator;Molecular;Molecular Probes;mouse model;novel therapeutics;Nuclear Translocation;Nucleic Acid Regulatory Sequences;Organ;pathogen;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Plasma Cells;Play;prevent;Process;Production;programs;Refractory;Research;response;Rheumatoid Arthritis;Role;Severity of illness;Signal Induction;Signal Pathway;Signal Transduction;Squalene;Study models;support network;Systemic Lupus Erythematosus;Systemic Therapy;Testing;Therapeutic Intervention;Time;Tissues;TLR7 gene;transcription factor;Transcription Factor AP-1;transcriptome;Up-Regulation;Vaccine Antigen;Vaccines

PROJECT_TITLE: TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signals

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: IOWA CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  The purpose of the Predoctoral Training Program in Genetics is to optimally prepare students in their PhD training in Genetics, to meet the challenging problems of genetics, genomics, bioinformatics and personal medicine, and to become leaders in the direction of new trends in Genetics research. Our mission for society is to generate scientists that can be at the forefront of Genetics research, who can in turn contribute to training and collaborating with physicians and other allied health professionals, and who can educate all members of society, who will increasingly need to understand genetic aspects of their own family's health care and individualized genomes. Because this need is among people from all walks of life, we emphasize diversity in our PhD students; with the pervasive implications of the individualized genome, including both the promises and the dangers of exploiting the information therein, the need to train competent PhD students is paramount.

PI_NAMEs: EBERL, DANIEL F (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;pre-doctoral;Training Programs

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The Integrative Training Program in Developmental Process trains researchers in typical and atypical patterns of behavioral and brain development, with the goal of understanding how early achievements in that process (for example, motor development, language learning, sleep patterns) set the stage for and support later achievements (for example, in sustained attention, behavioral control, school success). By understanding how development builds on itself and the potential multiple pathways to healthy developmental outcomes, we may foster healthy outcomes in children facing challenges from poverty, from sensory-motor disabilities, and from developmental disorders such as autism.

PI_NAMEs: SMITH, LINDA B. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Developmental Process;Training Programs

PROJECT_TITLE: Training Program in Integrative Developmental Process


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PHR: While a majority of studies show the pain-facilitating aspect of injury-related glial/immune activity, a potential loss of inhibitory/protective neuroglial interactions in the development of persistent pain has been largely overlooked. We propose to analyze inhibitory glial/immune activity related to nerve injury and whether disrupted immune homeostasis in the brain descending circuitry contributes to the development of chronic pain. Exploring protective/homeostatic glial activity will fill the gap in our understanding and help to develop therapeutic strategies that emphasize inducing homeostatic glial activity to restore normal neuronal activity, instead of simply blocking glial activity for pain management.

PI_NAMEs: REN, KE ;WEI, FENG  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Acute;Address;Anatomy;antagonist;Anterior;Anti-Inflammatory Agents;Attention;Attenuated;Behavioral;Biochemical;Brain;Calcium;CD 200;Cells;Central Nervous System;Chemicals;chronic constriction injury;chronic pain;chronic pain management;chronic painful condition;cingulate cortex;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;designer receptors exclusively activated by designer drugs;Development;Disease;Disinhibition;dorsal horn;equilibration disorder;Event;Excitatory Synapse;Exhibits;Failure;FOXP3 gene;Gene Deletion;Genetic;glial activation;Glutamate Transporter;Hippocampus;Homeostasis;Human;Image;Immune;immune function;Immunoglobulins;Immunohistochemistry;improved;inhibitory neuron;Injury;Measures;Mediating;Mediator;Medical;Microglia;Mus;Nerve;nerve injury;Neuroglia;Neuroimmune;Neurons;neurotransmission;Nociception;Nociceptors;novel;optogenetics;Pain;Pain Disorder;Pain management;pain sensitivity;painful neuropathy;Pathway interactions;Peripheral;Persistent pain;Persons;pharmacologic;Phase;Phenotype;preclinical study;Protein Analysis;receptor;Regulatory T-Lymphocyte;RNA;RNA Interference;Role;Serotonin;Serotonin Receptors 5-HT-3;Signal Pathway;Signal Transduction;Slice;Spinal;STAT6 Transcription Factor;Structure;System;Technology;Temporomandibular Joint Dysfunction Syndrome;Testing;Therapeutic;Transgenic Mice;Trigeminal System;two-photon;Up-Regulation;Viral

PROJECT_TITLE: Disruption of Homeostatic Neuroimmune Interactions in Descending Circuitry in the Development of Pain Chronicity

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Modern biomedical technologies, including rapid single-cell and whole tissue sequencing, high- content mass spectrometry, and modern imaging, are allowing systems-level analyses of complex diseases, such as cancer, heart disease and diabetes. Interpreting the large and complex data sets produced by these techniques requires use, and often development, of novel computational approaches. The Curriculum in Bioinformatics and Computational Biology at the University of North Carolina at Chapel Hill provides the graduate training needed to develop and apply computational methods for biomedical research with the goal of developing novel therapeutic strategies for treating complex diseases.

PI_NAMEs: ELSTON, TIMOTHY C;VALDAR, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: Predoctoral Training Program in Bioinformatics and Computational Biology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The development of alternative therapies for myocardial infarction is a necessity because of the large patient population. Innovative new approaches are needed, capable of application immediately following heart attack, to control deleterious processes leading to poor cardiac function following initial survival. This proposal seeks to develop new biomaterial based therapeutic platforms for treating acute myocardial infarction.

PI_NAMEs: CHRISTMAN, KAREN L (contact);GIANNESCHI, NATHAN CLAUDE

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acute myocardial infarction;Alternative Therapies;American;Animal Model;Antioxidants;aqueous;Biocompatible Materials;Biodistribution;biomaterial compatibility;Catheters;Cause of Death;controlled release;copolymer;cost effective;design;Development;Diameter;Drug Carriers;Drug Kinetics;Enzyme Induction;Enzymes;Evaluation;Exhibits;Flow Cytometry;Future;Gene Expression;Goals;Heart;Heart failure;heart function;hemocompatibility;Histology;Immune response;Immunohistochemistry;immunoregulation;improved;Infarction;Inflammation;Inhibition of Matrix Metalloproteinases Pathway;inhibitor therapy;Injectable;Injections;innovation;Kidney;Left Ventricular Remodeling;Liver;Magnetic Resonance Imaging;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Methods;minimally invasive;MMP2 gene;Modality;Molecular Weight;Myocardial;Myocardial Infarction;Myocardium;nano-string;nanomaterials;nanoparticle;nanopattern;nanoscale;NF-E2-related factor 2;novel;novel strategies;Operative Surgical Procedures;particle;Pathway interactions;patient population;Patients;peptide drug;Peptides;Pharmacologic Substance;Phase Transition;Polymers;Procedures;Process;Property;protein protein interaction;Proteins;Recovery;Recurrence;repaired;response;Rest;Safety;scaffold;Site;Spleen;Stress;Structure;success;System;targeted delivery;Testing;Therapeutic;therapeutic protein;therapeutic target;Translating;Translations;Vertebral column;Western World

PROJECT_TITLE: MMP responsive polymeric materials for treating acute myocardial infarction

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

ORG_STATE: OR

PHR: Project Narrative Based on formative research with targeted populations, this UG3/UH3 application will develop and evaluate a theoretically based digital dental health promotion program designed to engage lower income, Black/African American, Latinx, and white non-Hispanic 7th and 8th grade students. The school-based, web-based intervention will address existing dental health disparities by providing access to the program to all students via school internet and digital devices. The long-term goal of this project is to facilitate healthy dental care habits for adolescents by reducing persistent oral health disparities and preventing oral disease.

PI_NAMEs: FEIL, EDWARD GUSTAV;WESTLING, ERIKA  (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: access disparities;Address;Adolescence;Adolescent;Adolescent Behavior;Adult;Advisory Committees;African American;African American population;Attitude;Behavior;behavior change;Behavior Therapy;Behavioral;Black Populations;Black race;Caries prevention;Child;Chronic Disease;Clinical;Cognition;Collaborations;community partners;Consultations;Consumption;Control Groups;cost;COVID-19 pandemic;Dental;Dental Care;Dental caries;Dental Hygienists;design;Development;Devices;Diet;digital;digital intervention;digital platform;disparity reduction;E-learning;eighth grade;Ensure;ethnic disparity;ethnic diversity;Evaluation;Fluorides;Focus Groups;Goals;Habits;Health;Health behavior;health disparity;health knowledge;health management;Health Promotion;Hispanic;improved;income disparities;Internet;Intervention;intervention program;Latinx;life span;Low income;Minority;Modeling;Mouth Diseases;Not Hispanic or Latino;online delivery;Online Systems;Oral;Oral health;Orthodontic Appliances;Outcome;permanent tooth;Persons;Phase;Planning Theory;Population;Prevalence;prevent;Prevention;Prevention Research;Prevention strategy;Primary Prevention;Process;Program Acceptability;programs;prototype;Public Health;Quality of life;racial disparity;racial diversity;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Risk;Sampling;satisfaction;School-Age Population;Schools;secondary outcome;Self Care;seventh grade;Spanish;Spanish/English;Speed;student participation;Students;Subgroup;substance use;sugar;sweetened beverage;Target Populations;teacher;Technology;Teenagers;Testing;therapy design;Time;Tobacco use;Toothbrushing;Toothpaste;U-Series Cooperative Agreements;United States National Institutes of Health;usability;vaping;Waiting Lists;web-based intervention;willingness;Work;Youth

PROJECT_TITLE: Development and Evaluation of School-based Digital Adolescent Oral Health Promotion Program for the Reduction of Oral Health Disparities


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Infectious Diseases;Liver Disease

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Public Health Statement/Project Narrative Spontaneous bacterial peritonitis (SBP) is a common complication of cirrhosis and associated with high morbidity and mortality rates. Furthermore, due to the worldwide pandemic of multidrug-resistant organisms, the efficiency of antimicrobial therapy, the current standard of care, continues to deteriorate; hence, the development of novel management strategies is imperative. This proposal aims to advance our understanding of SBP pathophysiology through elucidating the role and significance of peritoneal macrophage, with the ultimate goal of defining novel therapeutic targets.

PI_NAMEs: SAITO, TAKESHI  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Animal Model;Anti-Bacterial Agents;Antibacterial Response;antimicrobial;Architecture;Ascites;bactericide;cell type;Cells;Characteristics;chemokine;Cirrhosis;Complication;cytokine;Death Rate;design;Deterioration;Development;Digestion;Down-Regulation;Effectiveness;Equilibrium;Exhibits;Exposure to;Frequencies;Functional disorder;Goals;gut dysbiosis;gut microbiota;Human;Immune;Immune Tolerance;Immunity;Immunologics;Impairment;In Vitro;in vivo;Infection;Infection Control;Inflammation Mediators;insight;Intestines;Invaded;Investigation;Knowledge;Maintenance;mesenteric lymphatics;Microbe;Modeling;Molecular;Morbidity - disease rate;multi-drug resistant pathogen;Natural Immunity;Neutrophil Activation;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutic intervention;Omentum;pandemic disease;pathogen;pathogenic bacteria;Patients;Pattern;Peritoneal;Peritoneal Fluid;Peritoneal Macrophages;Peritoneum;Peritonitis;Process;Production;programs;Property;Public Health;Rattus;Research;response;Role;secondary lymphoid organ;self-renewal;single-cell RNA sequencing;Spottings;standard of care;Stromal Cells;Testing;therapeutic target;transcription factor;Virulence;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: Role of Peritoneal Macrophage in Spontaneous Bacterial Peritonitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-A(04)]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Anemia is the most common blood disorder affecting more than two billion people worldwide, and occurs when red blood cells are reduced or when red blood cells do not function properly. Iron is essential to form hemoglobin, a protein within red blood cells that delivers oxygen to body tissues. Our studies reveal a novel iron-dependent mechanism for regulating red blood cell numbers that will provide new insights into the pathophysiology of blood disorders.

PI_NAMEs: LEIBOLD, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 3' Untranslated Regions;Affect;Alanine;Alleles;Anemia;Binding;Binding Proteins;Blood Cell Count;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Death;Cell Differentiation process;cell growth;cell growth regulation;Cell Lineage;Cell Survival;Cells;Characteristics;Codon Nucleotides;cofactor;CRISPR/Cas technology;Development;differentiation in vitro;DNA biosynthesis;Duodenum;Dysmyelopoietic Syndromes;Elements;Embryo;Engineering;Enterobacteria phage P1 Cre recombinase;Enterocytes;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;Exhibits;Ferritin;Fibroblasts;Flow Cytometry;Functional disorder;G2 Phase;Gene Expression;Generations;Goals;Hela Cells;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic stem cells;Heme;Hemoglobin;in vivo;Inherited;insight;Iron;iron deficiency;iron metabolism;Iron Regulatory Protein 2;Knock-in Mouse;LoxP-flanked allele;Macrocytic Anemia;Mediating;Messenger RNA;metal transporting protein 1;Mitochondria;Mitosis;Molecular;mouse model;Mouse Strains;mRNA Stability;mRNA Translation;Mus;mutant;Mutate;novel;Oxidative Stress;Oxygen;Pathway interactions;Persons;Phenotype;Phosphorylation;Physiological;Population;posttranscriptional;Process;Production;Proliferating;Proteins;Proteomics;Reporting;Respiration;RNA;RNA Binding;Role;S phase;Serine;Serum;single-cell RNA sequencing;SKP Cullin F-Box Protein Ligases;Spleen;Splenomegaly;stem;stem cell proliferation;Supporting Cell;System;Testing;TFRC gene;Tissues;Translations;transplant model;Transplantation;ubiquitin ligase;uptake

PROJECT_TITLE: Cell Cycle Regulation of IRP2 Phosphorylation During Hematopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Center for Healthy Aging Behaviors and Longitudinal InvestigationS (CHABLIS) will promote research in the demography and economics of aging and assist junior scholars as they engage in this research domain. We draw on projects such as NSHAP and CCP to develop opportunities for scholars, both junior and senior, to collaborate on science and survey methods in a longitudinal context.

PI_NAMEs: MELTZER, DAVID O (contact);WAITE, LINDA J

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Administrative Efficiency;Affect;Aging;aging population;Area;Attention;Behavior;Biology;career;career development;Censuses;Centers for Population Health;Chicago;Cohort Studies;Collaborations;Communities;Community Healthcare;Comprehensive Health Care;Conceptions;Consultations;Data;Data Analyses;Data Collection;data harmonization;data resource;Data Set;Data Sources;Demographic Factors;Demography;Dental Care;design;Development;Disadvantaged;Discipline;diverse data;early-career faculty;Economic Factors;Economics;Educational workshop;Ensure;Evaluation;Event;experience;Fees;Future;Goals;Grant;Health;Health behavior;health disparity;Healthcare;healthy aging;Incentives;Individual;Influentials;Information Sciences;Infrastructure;infrastructure development;innovation;Institution;Institutional Policy;insurance claims;Intervention Studies;Investigation;Joints;Lead;Life;Life Cycle Stages;Literature;Longitudinal Studies;Measurement;Medical;Medicine;member;Mentors;Methodology;Methods;Monitor;Neighborhoods;next generation;novel;novel strategies;Observational Study;older adult;Outcome;personalized medicine;Persons;Pharmacogenetics;Physicians;Pilot Projects;Policies;Population;Prisons;Privatization;Process;Productivity;Program Development;programs;Randomized;Research;research and development;Research Personnel;research study;Research Support;Resources;Retirement;Schools;Science;social;Social Sciences;socioeconomic disadvantage;Sociology;summer institute;Survey Methodology;synergism;Techniques;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Center for Health Aging Behaviors and Longitudinal InvestigationS (CHABLIS)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Prevention

PI_NAMEs: MELTZER, DAVID O (contact)

PROJECT_TERMS: Affect;Aging;Applications Grants;Area;Award;Behavior;Biological Sciences;Black race;Budgets;career development;Communication;Computer software;Data;Demographic Factors;Demography;Development;Discipline;Economic Factors;Economics;Ensure;Equipment;Expenditure;Fostering;Funding;Funding Opportunities;Geriatrics;Goals;Grant;Health;Health behavior;Health Sciences;healthy aging;infrastructure development;Internal Medicine;Intervention Studies;Investigation;Journals;Leadership;Maintenance;meeting reports;meetings;member;Mentors;Monitor;Observational Study;Occupational activity of managing finances;older adult;Outcome;Performance;Pilot Projects;Population;Productivity;Program Development;programs;Progress Reports;Public Health;Public Policy;Publications;recruit;Reporting;Research;research and development;research data dissemination;Research Personnel;Research Support;Secure;Services;Shapes;Social Sciences;Sociology;Strategic vision;Structure;symposium;Travel;Update;web site;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Multidrug-resistant Acinetobacter baumannii is a cause of highly recalcitrant diseases in hospitals that compromise our ability to deliver health care to patients. This application proposes to study a unique two- protein system that is the global control center for both antibiotic resistance and pathogenicity in the bacterium. This research will uncover how the system modulates envelope synthesis to respond to antimicrobial stress, facilitate disease, and cause antibiotic failure, and will form a base for the development of strategies for lowering the defenses of the pathogen to enhance the treatment of nosocomial disease.

PI_NAMEs: GEISINGER, EDWARD  (contact)

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;addiction;Anabolism;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;base;biological adaptation to stress;Bypass;candidate identification;cell envelope;Cell Membrane Permeability;Cell Physiology;Cells;chemical genetics;Clinical;Data;Dedications;Defect;Dependence;Development;Disease;Drug resistance;drug resistant bacteria;drug resistant pathogen;env Gene Products;experimental study;extensive drug resistance;Face;Failure;Gene Fusion;Genes;genetic regulatory protein;Goals;Growth;Healthcare;Heart;Homeostasis;Hospitals;Human;Immune;Immune Evasion;In Vitro;Infection;infection management;Innate Immune System;knock-down;Knowledge;Lesion;Link;member;Membrane;Membrane Proteins;Microbe;Microbial Biofilms;microorganism;Modeling;mortality;Multidrug-resistant Acinetobacter;Mus;Mutation;Names;Orthologous Gene;pathogen;Pathogenicity;Pathway interactions;Patient Isolation;Patients;Penetration;Permeability;Pharmaceutical Preparations;Phospholipids;Phosphorylation;Predisposition;Production;promoter;Protein Biosynthesis;Proteins;Public Health;Regulation;Regulon;Reporter;Research;Resistance;response;Ribosomes;Sensory;Sepsis;Signal Transduction;Stress;Surface;System;Testing;therapeutic target;Translational Repression;transposon sequencing;Treatment Failure;Variant;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Global Circuitry that Controls Acinetobacter Resistance and Virulence