NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Patient Safety;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Food allergy impacts 8% of children in the US. Clinical data from electronic health records (EHR) are needed to explore the FORWARD study outcomes including racial and ethnic differences in food allergy development, tolerance, management, phenotypes, and endotypes. However, data extraction methods and EHR systems are not consistent across all study sites and therefore, this administrative supplement aims to standardize food allergy-related EHR data extraction to more efficiently and effectively measure study outcomes.

PI_NAMEs: GUPTA, RUCHI S (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Administrative Supplement;Adolescence;Adopted;Affect;Allergic;Anaphylaxis;Asian;Asian population;Asthma;Award;Black race;Child;Clinical;Clinical Data;clinical development;Code;cohort;Cohort Studies;comorbidity;Consent;Data;Data Collection;data dictionary;Data Element;data harmonization;data integration;data modeling;Data Set;data standards;Databases;Development;Diagnosis;diverse data;Documentation;Eczema;electronic data;Electronic Health Record;electronic health record system;Electronics;Emergency department visit;Enrollment;Ensure;ethnic difference;ethnic disparity;Ethnic Origin;Etiology;experience;Family;Food;food challenge;Food Hypersensitivity;Funding;Geography;Goals;Grant;Hispanic;Hospitalization;Hypersensitivity;IgE;Immune Tolerance;Impairment;Individual;Infrastructure;Latino;Life;Location;Manuals;Measures;Medical;Methods;Modeling;Oral;Outcome;Outcome Study;parent project;Parents;Participant;participant enrollment;patient population;Persons;Phenotype;Physicians;Population Heterogeneity;Practice Management;Prevalence;Privatization;psychosocial outcome;Race;racial difference;racial disparity;Reaction;recruit;Research Personnel;Resources;Sampling;Severities;Site;skin prick test;sociodemographics;Source;Standardization;Structure;Surveys;Symptoms;Testing;United States;Variant;Visit;Vocabulary;Work

PROJECT_TITLE: FORWARD Supplement Standardizing EHR Data Collection


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The objective of this work is to understand the diversity of clinical presentation in sickle cell disease by studying how heterogeneity propagates from molecules to cells to systemic blood flow. Additionally, we will develop models, tools, and assays that will enable clinical management and therapeutic development.

PI_NAMEs: WOOD, DAVID KEVIN (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 3-Dimensional;acute chest syndrome;Aneurysm;Behavior;Biological Assay;Biophysical Process;Biophysics;Blood;Blood flow;blood rheology;Blood Vessels;Cells;Chronic;Circulation;Clinic;Clinical;Clinical Management;Communities;Development;Endothelium;Fiber;Functional disorder;Funding;gene therapy;Growth;Hematocrit procedure;Hemoglobin;hemoglobin polymer;Heterogeneity;hydroxyurea;Image;Individual;Injury;insight;Kinetics;Label;Link;Liquid substance;Measurement;mechanical properties;Microscopy;Modeling;Molecular;multi-scale modeling;novel therapeutics;Oxygen;Pathology;Patients;Physiological;polymerization;Polymers;Population;Population Heterogeneity;Property;Resolution;Role;self assembly;shear stress;Sickle Cell Anemia;Sickle Hemoglobin;sickling;spatiotemporal;Stroke;Structure;submicron;System;Technology;Testing;therapeutic development;Therapeutic Intervention;tool;Transfusion;Translating;viscoelasticity;Whole Blood;Work

PROJECT_TITLE: Developing a multiscale understanding of biophysical processes in sickle cell disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Pediatric;Rare Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Cystic fibrosis (CF) is a common genetic disease caused by a defect in the membrane pore protein CFTR, and CF lung disease is the most common cause of death in CF patients. This proposal addresses how mutation of a membrane pore protein leads to infection and bacterial growth, and how these characteristic features of CF lung disease differ in the different regions of the lung. Defining regional differences in development of CF lung disease is essential to understand the disease's origins and to identify new therapeutic pathways for CF.

PI_NAMEs: LI, XIAOPENG  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;airway epithelium;airway obstruction;airway surface liquid;Animal Model;Bacterial Infections;Bicarbonates;Cause of Death;cell type;Cells;cellular targeting;Cellular Tropism;Characteristics;chemical property;chronic infection;Clinical Data;Complementary DNA;Cystic Fibrosis;cystic fibrosis airway epithelia;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Dependovirus;Development;Diameter;Disease;DNA Sequence Alteration;Engineering;Epithelial Cells;experience;Family suidae;Gene Delivery;Genetic Diseases;Goals;Growth;Host Defense;Host Defense Mechanism;Human;human disease;Impairment;In Vitro;in vivo;Infection;Inflammatory;Injections;Iowa;Lung;Lung Diseases;Lung infections;Mediating;Membrane;Modeling;Mucous body substance;Mus;Mutate;Mutation;novel;novel therapeutics;Organ;Pathogenesis;Pathologic;Pathway interactions;physical property;Play;porcine model;Pore Proteins;preclinical study;prevent;Property;public health relevance;Pulmonary Cystic Fibrosis;regional difference;Regulation;respiratory examination;restoration;Role;Sampling;Satellite Viruses;Serotyping;stem cells;targeted delivery;Testing;Therapeutic;Tissues;Trachea;transduction efficiency;translational potential;Tropism;vector;Viral Vector;Viscosity

PROJECT_TITLE: Role of disrupted ASL pH regulation in small airways in CF lung disease pathogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Each cell interacts with its environment, and 1000s of human genes encode the needed hormones, receptors, transporters, and enzymes. Most are produced in the secretory pathway, but the complexity of this pathway makes it difficult to diagnose the molecular basis of associated diseases, including Alzheimer’s disease, metabolic syndrome, cancer, and many infectious diseases. Here we develop a computational platform and experimental data resource enabling researchers to study the pathway as a whole system.

PI_NAMEs: LEWIS, NATHAN ENOCH (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: algorithm development;Algorithms;Alzheimer's Disease;amyloid formation;base;Cell Adhesion Molecules;Cell Communication;cell type;Cells;Code;Communicable Diseases;Communication;Communities;computational platform;Computer Models;data resource;Disease;endoplasmic reticulum stress;Environment;Enzymes;experimental study;extracellular;Extracellular Matrix;Genes;Genomics;Hormone secretion;Hormones;Human;Human Genome;Individual;Liver;Malignant Neoplasms;Maps;Mathematics;Membrane Proteins;Messenger RNA;Metabolic syndrome;Modeling;Molecular Diagnosis;Pathway interactions;Process;Production;Protein Secretion;Proteins;receptor;Research Personnel;Resources;Role;Signal Transduction;software development;System;Systems Biology;Techniques;Tissues;tool;trafficking;Work

PROJECT_TITLE: Unraveling the mammalian secretory pathway through systems biology and algorithm development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: 8. Project Narrative Adolescence is an “age of risk” for the emergence of bipolar spectrum disorders (BSDs), a major public health problem. Using an innovative biobehavioral high-risk approach with a prospective, longitudinal design, this application will examine bidirectional relationships between circadian and reward function at multiple levels of analysis and their joint prediction of first onset of BSD and increases in hypomanic/manic and depressive symptoms. It will provide critical tools for identifying vulnerabilities for first onset of BSD, integrate two separate research traditions to increase our understanding of specific etiological pathways to BSD, and facilitate development of behavioral and biological interventions for ameliorating reward processing and circadian rhythm abnormalities that contribute to BSDs, and their lifelong negative consequences.

PI_NAMEs: ALLOY, LAUREN BERSH (contact);NUSSLOCK, ROBIN

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 16 year old;actigraphy;Adolescence;Adolescent;Affect;Age;Behavioral;biobehavior;Biological;bipolar spectrum;Brain;Chronic;circadian;Circadian Dysregulation;Circadian Rhythms;Code;depressive symptoms;design;Development;Diagnostic;Dimensions;Disease;Ecological momentary assessment;Etiology;Event;Exclusion;Feedback;functional MRI scan;Goals;high reward;high risk;Hypersensitivity;hypomania;indexing;innovation;Intervention;Joints;Life;Light;Literature;longitudinal design;Longitudinal Studies;Manic;Measures;Mediating;Mediator;Melatonin;Modeling;mood symptom;Moods;negative affect;neural;neuroimaging;novel;Onset of illness;Participant;Pathway interactions;Patient Self-Report;Phase;Physiological;Prevalence;prevent;Procedures;prospective;Public Health;Recording of previous events;Recurrence;Research;reward processing;Rewards;Risk;Risk Marker;Salivary;Sampling;Signal Transduction;Sleep;social;social engagement;Stimulus;Symptoms;synergism;System;Tail;Testing;Time;tool;trait;Work

PROJECT_TITLE: Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Cardiovascular;Hematology

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Extracorporeal circulation through a membrane oxygenator (ECMO) is used for severe heart and lung failure support worldwide, despite a high incidence of bleeding caused by systemic anticoagulation. Without adequate systemic anticoagulation components of the ECMO circuit are prone to clotting putting at risk patients. This research will refine our nitric oxide (NO) based nonthrombogenic surface which can eliminate systemic anticoagulation and set the stage for commercial development.

PI_NAMEs: ROJAS-PENA, ALVARO  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Accounting;Adhesions;Affect;Animal Model;Anticoagulants;Anticoagulation;Argatroban;Attention;Binding;Blood flow;Blood Platelets;Cardiopulmonary Bypass;Chemistry;Clinical Trials;Coagulation Process;commercial application;compare effectiveness;comparison control;Critical Care;design;Development;Devices;Dose;Effectiveness;effectiveness evaluation;Endothelium;Experimental Designs;experimental study;Extracorporeal Circulation;Fibrin;Functional disorder;Gases;Generations;Goals;Grant;Heart failure;Hemodialysis;Hemofiltration;Hemorrhage;Heparin;Hour;hydrophilicity;Incidence;inhibitor;Laboratories;Learning;Life;lung failure;Medicine;Membrane Oxygenators;Morbidity - disease rate;mortality;Nitric Oxide;Oxygenators;Patients;Platelet Activation;platelet function;pre-clinical;prevent;prototype;Research;Research Project Grants;Risk;SARS-CoV-2 infection;Series;Sheep;Source;Standardization;Surface;surface coating;System;Technology;Testing;Thrombin;thrombogenesis;Thrombosis;Time;United States National Institutes of Health

PROJECT_TITLE: ECMO without Anticoagulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: NEW ORLEANS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: No PHR

PI_NAMEs: JONES, SHANTOYIA S;LEMIEUX, KITANI  (contact);MURRAY, DEBRA DIANNE

PROGRAM_OFFICER_NAME: BLACKBURNE, FAITH THERESA

PROJECT_TITLE: Xavier University of Louisiana Reaches the Underrepresented in Biomedical Research (XULA RUBR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The work in these studies will generate fundamental knowledge of the molecular mechanisms underlying the protein-protein interactions of the APP ectodomain and the cellular consequences of these interactions across different cell types. These studies have the potential to lay the foundation for future work to harness the fundamental functions of APP to counteract pathogenic pathways in Alzheimer’s disease, Down syndrome, and obesity.

PI_NAMEs: RICE, HEATHER C. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Affinity;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Binding;Cell Membrane Proteins;Cell Physiology;Cell Surface Proteins;cell type;cognitive function;design;Disease;Down's Syndrome;Etiology;Extracellular Domain;Family member;Foundations;Future;GABA-B Receptor;gamma-Aminobutyric Acid;Generations;Goals;Health;Knowledge;Lead;Length;Ligand Binding;Ligands;Mediating;Membrane Proteins;Mitochondria;Molecular;Neuroglia;novel;Obesity;Pathogenicity;Pathway interactions;Phosphoglycerate Mutase;Phosphorylation;Physiological;Protein Fragment;protein function;protein protein interaction;Protein Serine/Threonine Phosphatase;Proteolytic Processing;receptor;Receptor Signaling;Regulation;Research;response;Signal Pathway;Signal Transduction;Work

PROJECT_TITLE: Mechanisms of APP ectodomain function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: 1. Background The burden of HIV disease worldwide remains disproportionally concentrated in sub-Saharan Africa (SSA), the only region with the majority of HIV infections occurring among women and a region with exceptionally high rates among young women aged 15-24. Control of the HIV epidemic globally, in SSA and in a country like Kenya in the top 10 high HIV burden countries requires increased attention to the condition of women and adolescent girls. In such countries effective implementation and expansion of HIV prevention and treatment interventions that have been proven to work are urgently needed. In addition, it is critical to understand the biological, psychological and structural factors, as well as unique co-morbidities, that women living with HIV (WLHIV) face, especially as they age. Building the in-country capacity to design and conduct implementation-focused research addressing the health of women affected by HIV is the primary goal of the parent Fogarty-funded program led by Drs. Elizabeth Bukusi (Kenya Medical Research Institute [KEMRI]) and Carey Farquhar (University of Washington [UW]), entitled, Women and HIV: Translation of Research into Practice (WHIV). From 2015 to the present, the WHIV Fogarty training program has supported 27 researchers as they have earned advanced degrees at the University of Washington and University of Nairobi (23 MPH, 4 PhD). One major challenge for these trainees has been bridging the gap between their advanced degree training and establishing an independent research career. Those who have successfully obtained a K43 or similar career development award have been able to launch their research careers. Those who have not been able to secure post-graduate funding have had a more challenging time achieving independence and instead have largely remained as co-investigators on others’ grants. Post-graduate funding is essential to ensure success of recent graduates conducting research to address important gaps in the health of women living with HIV and increase our understanding of the intersectionality of HIV infection and women’s health, and the long-term effects of HIV for women. Providing funding, mentorship and support for new investigators to successfully transition into initiating independent research on HIV and women’s health issues is the primary goal of this supplement. 2. Objective We propose to leverage the KEMRI/UW WHIV Fogarty D43 training program to increase capacity for research responsive to this request for applications by supporting two new investigators who recently graduated with an MPH from UW. They will conduct high-impact mentored research in Kenya focused on health of WLHIV across the lifecycle, leading to their independence as an investigator and a strong foundation for a research career. 3. Approach 3.1 Overview The supplement will support two new MPH graduates launch their research careers in Kenya by providing by providing them with tools, mentorship, and experience to bridge them to an independent career in HIV research focused on women living with HIV and women’s health at KEMRI and partner institutions. The one-year post- graduate fellowship award includes funding for a stipend and for the candidate’s own research project. It also includes mentorship from a team of highly qualified KEMRI and UW researchers, individual coaching, group meetings, seminars, and skills- building workshops to promote their career development. 3.2 Program leadership The proposed program will be directed by Dr. Elizabeth Bukusi at KEMRI with support from Dr. Carey Farquhar and the administrative team at UW. Both Drs. Farquhar and Bukusi have substantial experience with Fogarty training programs, as well as other training programs in Kenya. They have been successfully co-directing the Women and HIV: Translation of Research into Policy training program since it was funded 9 years ago and are excited to continue to work together and co-lead activities proposed in this supplement. Elizabeth Bukusi, MBChB, MMed, MPH, PhD, Program Director, is an obstetrician/gynecologist, epidemiologist and a Chief Research Officer at the Center for Microbiology Research, KEMRI. She earned an MPH in 2000 and PhD in Epidemiology at the UW in 2006. Dr. Bukusi was awarded a postgraduate diploma in research ethics (University of Cape Town) in 2010 and completed a master’s degree in Bioethics. Her research focuses on sexually transmitted infections, reproductive health and HIV prevention, care and treatment and she was one of the two co-founders of KEMRI’s Research Care and Treatment Program (RCTP). She was founding chair of KEMRI’s Program on Sexual, Reproductive, Adolescent and Child Health and currently serves as Core Faculty for the Fogarty-funded UCSF Glo-Cal Fellowship. She co-chaired the HPTN Women at Risk Committee and serves on the Kenya MOH National HIV Prevention Task Force. In the last 25 years she has mentored over 100 Kenyan and international scholars and is the PI/Co Director for a FIC Bioethics Training Program expanding Masters training in 2 Kenyan universities. She is also an accredited executive coach. Carey Farquhar, MD, MPH, Program Director, is a Professor jointly appointed in the Departments of Global Health, Medicine and Epidemiology at the University of Washington and Director of the UW IARTP since 2003. In May 2022, she was appointed the Interim Chair of the UW Department of Global Health. Her research has focused most recently on HIV testing and assisted partner notification services in Kenya, HIV and cardiovascular disease risk factors, and research with marginalized and unreached populations, such as persons who inject drugs. She has mentored more than 60 US and Kenyan trainees earning degrees at UW and published more than 260 papers on HIV-related topics, global health leadership and capacity building in under-resourced settings, ~25% of which have her trainees as first author. Several of her trainees have been successful obtaining NIH career development awards, such as the GRIP (1), K43 (3), K01 (1), K23 (2), as well as NIH Diversity supplements (2). 3.3 Selection process The KEMRI/UW WHIV program has issued a request for proposals from our alumni and networks and has identified 4 post-graduate researchers as finalists for this funding opportunity. These 4 will submit full-length proposals for review by the WHIV Technical Advisory Committee (TAC) which will recommend two finalists to receive research funding and support for the one-year fellowship. TAC members include Dr. Dorothy Mbori-Ngacha, Dr. Criag Cohen, Dr. Patty Garcia, Dr. Edwin Were and Dr. Joseph Zunt. All 5 have extensive experience with Fogarty training programs and have been WHIV TAC members since 2015. They are familiar with the training opportunities, mentors, and resources available in Kenya for graduates of the WHIV program and will be able to identify trainees with the highest potential for success, the strongest mentorship teams, as well as those projects that are high-impact and feasible in the available timeframe available. They will be provided with a rubric and asked to assess the applications using criteria for the candidate, proposed mentorship team and the research project. Candidates must have a track record of excellent performance and a clear goal statement, expressing their commitment to working in the field of women’s health and HIV; mentorship teams must include mentors at both KEMRI and UW who have expertise in the research area as well as in mentoring trainees at this level; research projects will be considered based on their responsiveness to the call for research on women living with HIV across the lifecycle and their potential for impact, innovation and feasibility. 3.4 Finalist candidates and proposed studies The 4 finalists for this post-graduate fellowship are listed below followed by brief biographies and overviews of the research projects they are proposing and their mentorship teams (Table 1). Biosketches for the finalists are also included as attachments to this proposal. Of these 4 finalists, 2 will be selected by the WHIV TAC for the post-graduate fellowship which will include funding project expenses, as well as a stipend to provide fellows with time to conduct the research. Shradha Doshi, MBChB, MMed, MPH: Cardiovascular health and risk stratification in women aging with HIV Dr. Shradha Doshi is a medical doctor from Kenya. She earned her Bachelor of Medicine, Bachelor of Surgery, and Master of Medicine degrees from the University of Nairobi, Kenya. She has 16 years of experience as a doctor, nine of which she has focused on HIV care and treatment. As a consultant physician, Dr. Doshi practices clinical medicine at The Aga Khan University Hospital in Nairobi, Kenya. She has also worked in HIV prevention research in Kenya with the Kenya Medical Research Institute. Her primary research interests were pulmonary hypertension and the use of cardiovascular biomarkers as diagnostic, prognostic, and predictive markers in heart failure. Dr. Doshi received her MPH in Global Health from the UW in 2023 and her thesis was entitled, “Association between mild chronic kidney disease and coronary artery disease in persons living with and without HIV in Uganda.” Dr. Doshi proposes to conduct a cross-sectional study involving 100 women over the age of 50 who are living with HIV. This study aims to evaluate cardiac abnormalities in older women living with HIV by utilizing 2D echocardiograms and NT-pro BNP levels and factors associated with this finding. Few studies have assessed comprehensive aging data with echocardiographic assessments and biomarker analysis. Dr. Doshi aims to fill the gap by enhancing understanding of the interplay between frailty, osteoporosis, and cardiovascular health in this population. The specific aims include 1) to determine the prevalence of cardiac abnormalities in older women living with HIV using 2D echocardiographic assessments. 2) To evaluate the levels of NT-pro BNP as a biomarker for cardiovascular risk and potential heart failure in older women living with HIV. 3) To correlate traditional cardiovascular risk factors and NT pro-BNP levels with echocardiographic findings. The study will leverage the supplement to the Fogarty-funded D43 award entitled, Women and HIV: Translation of Research into Policy (TW009783). The parent study investigates the prevalence and correlates of frailty and osteoporosis among women aged 50 and above with HIV. Dr. Doshi will utilize existing data from the parent study, including age, sex, duration of HIV, antiretroviral therapy (ART) usage and type, CD4 count and viral load, history of cardiovascular risk factors like smoking, diabetes, hypertension and body mass index (BMI), current HbA1c levels, and dual-energy X-ray absorptiometry (DEXA) scan parameters such as T-score and body composition and frailty scores. The study will additionally conduct blood draws to measure NT-pro BNP levels to screen for potential heart failure. She will also collect additional data on structural and functional cardiac status by performing 2D Echocardiography and NT pro-BNP on participants. Table 1. WHIV Post-graduate Fellow Candidates, Proposed Research and Mentors Name/Title Date, Degree, Institution Research Area Mentors Shradha Doshi, MBChB, MMed, MPH  August 2023,  MPH in Global Health, University of Washington  Cardiovascular health and risk stratification in women aging with HIV  Sarah Masyuko, Carey Farquhar, Chris Longenecker, Elizabeth Bukusi,  Rose Bosire Stanley Ndwiga,  MBChB, MPH  June 2024,  MPH in Global Health, University of Washington  Psychosocial factors influencing  viral suppression among adolescents and young adults living  with HIV Kenneth Ngure, Nelly Mugo, and  Kenneth Mugwanya Marilyn Nyabuti, MBChB, MPH  August 2024,  MPH in Global Health, University of Washington  Structured counseling and warm  handoffs to promote successful  linkage of WLHIV during the transition from maternal and child  health clinics to comprehensive  care centers Carey Farquhar, James Ayieko, and  Cyrus Mugo Dismas Ouma, MBChB, MPH  June 2024,  MPH in Global Health, University of Washington Evaluating the integration of point  of care for STI screening into the routine care of women living with  HIV aged 18-49 years  Susan Graham,. Elizabeth  Harrington, Cyrus Mugo, Maricianah Onono, and Elizabeth Bukusi Stanley Ndwiga, MBChB, MPH: Exploring the Psychosocial Factors Influencing Viral Suppression among Adolescents and Young Adults Living with HIV: A Qualitative Follow-up Study Dr. Stanley Ndwiga is a medical doctor at the Kenya Medical Research Institute (KEMRI) and most recently was a study coordinator, supervising teams of research clinicians. He also coordinated study regulatory matters, drafted SOPs and trained study staff on study protocol and study operational manuals. For the last three years, he has worked in HIV prevention research in Kenya with KEMRI. Dr. Ndwiga received his MPH in Global Health from the University of Washington in June 2024. Dr. Ndwiga’s study aims to provide deeper insights into the psychosocial challenges faced by Adolescents and Young Adults (AYA) living with HIV to inform the development of targeted interventions and improve adherence to ART and viral suppression. The findings will help healthcare providers tailor support services to better meet the needs of this population and contribute to the broader literature on HIV care and support, particularly in Kenya and similar resource-limited settings, highlighting the importance of addressing mental health, stigma, and social support in the management of HIV among AYA. The primary objective of this study is to explore the personal experiences and perspectives of adolescents and young adults living with HIV, focusing on how psychosocial factors affect their ability to achieve and maintain viral suppression. The secondary objectives include identifying barriers and facilitators to achieving viral suppression, understanding the role of primary care givers and other social support systems and stigma in adherence to antiretroviral therapy (ART), and exploring the coping mechanisms and interventions that AYA find most acceptable and effective. This study will employ a phenomenological qualitative design, utilizing in-depth interviews and focus group discussions to gather detailed information. The population of interest includes AYA aged 15-24 years living with HIV who participated in a previous quantitative study. The study will be conducted at the Thika Partners in Health Research and Development (PHRD) research clinic in Kiambu County, Kenya, and will also include participants from Murang’a and Nairobi Counties. Purposive sampling will be used to select participants who exhibit a range of experiences with viral suppression and psychosocial challenges. Data will be collected through the use semi-structured interview guides informed by the CFIR framework and conducted by trained qualitative researchers. Thematic analysis will be used to identify and interpret patterns and themes related to psychosocial factors and their impact on viral suppression. Marilyn Nyabuti, MBChB, MPH: Structured counseling and warm handover to promote successful linkage of WLHIV during the transition from MCH to CCC Dr. Marilyn Nyabuti is a medical doctor trained at the University of Nairobi, Kenya, and is a team lead/co- investigator in a NIH-funded clinical trial in Western Kenya. She received her MPH in Global Health from the University of Washington in August 2024. Dr. Nyabuti’s research interest lies in understanding the unique cyclic barriers adolescents and youth seeking HIV prevention and treatment contend with as they transition through the different life-stages. Dr. Nyabuti’s study aims to provide evidence demonstrating the need for guidelines to assist healthcare providers to ensure uniform services for women living with HIV during the transition period from MCH to CCC, and to reduce the incidence of treatment interruptions among these women. Dr. Nyabuti proposes an intervention to provide targeted psychosocial counseling three months in advance, followed by a warm handover to CCC staff for WLHIV at increased risk of HIV treatment interruption (women <25 years, screening positive for depression, and newly diagnosed with HIV during PMTCT follow-up). The specific aims of this intervention are: 1) To evaluate the correlation between structured psychosocial counselling and warm handover and successful linkage to CCC during transition from MCH to CCC. 2) To assess the impact of counselling and a warm handover during transition from MCH to CCC on one year retention in HIV care. 3) to estimate the incremental cost of offering targeted counselling and a warm handover to WLHIV during the transition from MCH to CCC. Dr. Nyabuti will use a cluster-randomized control study with randomization at clinic level to enroll at least 300 women living with HIV aged 15 years and above who have completed PMTCT follow up and are scheduled for transition to the CCC who screen positive for any form of depression or aged <25 years old or newly diagnosed with HIV during PMTCT follow up. Each participant will have 4 study visits as follows: 3 months prior to transition, on day of transition, within 2 weeks after CCC appointment date, and 1 year post transition. Additionally, she will collect micro-costing and time and motion data to compare the resources used to deliver the intervention to the resources used in standard of care. She postulates that the intervention will reduce the proportion of women who miss their initial visit at CCC after transition and facilitate sustained retention up to 1 year post transition thus improving their health outcomes and improving their quality of life. In addition, she hopes that her results will inform the development of clinical guidelines that will guide healthcare workers when transitioning women from PMTCT to CCC. Dismas Ouma Congo, MBChB, MPH: A pilot study to evaluate the integration of point of care for sexually transmitted infection screening into the routine care of women living with HIV aged 18 to 49 years Dr. Dismas Ouma Congo is a research scientist at the Kenya Medical Research Institute (KEMRI), Centre for Microbiology Research in Kisumu. In this role, he develops clinical standard operating procedures, executes them, ensures participant safety and general health, and submits safety reports to both sponsors and local ethics committees. Dr. Ouma Congo received his MPH in Global Health at the University of Washington in June 2024 and was awarded the Outstanding MPH Student award by the Department of Global Health. Dr. Ouma proposes a study to evaluate organizational readiness, as well as the feasibility and acceptability of the use of POCT for STI screening and management, using self-collected genital swabs in the Lumumba subcounty HIV care clinic in Kisumu County. His proposed study hinges on the central hypothesis that a POCT for STI testing that integrates self-collection by WLHIV and links them to treatment offers distinct advantages from a syndromic or provider-collected swab approach. According to UNAIDS 2022 report, approximately one million women aged between 15-49 years were living with HIV in Kenya, with the highest incidence of new HIV infections occurring among women aged 15-24 years. No studies in Kenya currently assess the use of POCT for STI testing among WLWH, the most affected group, and allowing for self-collection of samples. This study includes the following aims: 1) To determine factors influencing the acceptability and feasibility of POC STI testing for WLHIV, and characterize baseline readiness to implement POC STI testing. The study will administer surveys and conduct workshops with WLWH attending their routine care clinic and the healthcare providers to assess the acceptability and feasibility of POC STI testing. 2) To pilot POC STI testing for WLWH and determine early implementation outcomes, including acceptability, feasibility, appropriateness, and understand factors necessary for expanded use. The study will pilot the use of POC STI testing among 100 WLWH-attending their routine HIV care clinic using self-collected swabs. Dr. Ouma will use the laboratory at the Lumumba CIS building to conduct POC STI testing for CT, GC, and TV. This laboratory has staff with extensive experience in POCT for STIs. The estimated turnaround time is 2 hours. Those who test positive will be treated according to 2022 National STI treatment guidelines and offer intimate partner notification and testing for those who agree to notify their sexual partners. Dr. Ouma will also administer surveys to assess factors associated with STIs including socio-demographic variables, sex and relationships, and reproductive history. He will also conduct a focus group discussion with WLWH and key informant interviews with providers to assess factors necessary for expanded use of POC STI testing in HIV clinics using self-collected swabs. Responsible Conduct of Research (RCR): All the trainees identified as finalists for this fellowship have completed the RCR course at the University of Washington in Fall 2022 and have met NIH’s RCR training requirements. 3.5 Mentors Mentorship will be a critical component of this project. The post-graduate fellows will meet weekly with mentors and the entire team (fellows and mentors) will meet quarterly to report on professional development goals and research updates. The trainees will also participate in monthly IARTP seminars and other forums. In addition to the program leaders, the mentorship team at KEMRI and UW includes: Sarah Masyuko, MBChB, MPH, PhD, Assistant Professor, UW Department of Global Health. Dr. Sarah Masyuko received her Masters in Global Health and her PhD in Global Health-Implementation Science from the University of Washington. She has been the lead of the HIV Testing Services and Pre Exposure Prophylaxis (PrEP) program at the National AIDS and STI Control Program (NASCOP) with the Kenyan Ministry of Health. Dr. Masyuko has been involved in research that spans from designing, implementing, disseminating and bringing to scale evidence-based health interventions. Her research interests are in implementation science with the direct translation of research results into policy and practice in HIV Prevention, Care and Treatment and Non- communicable diseases in low- and middle-income countries. Cyrus Mugo, MBChB, MPH, PhD, Senior Research Scientist at Kenyatta National Hospital. Dr. Mugo received his Masters in Global Health and his PhD in Epidemiology from the University of Washington. His research focus has been on improving treatment outcomes for adolescents and young adults living with HIV. He has 10-years of experience coordinating pediatric and adolescent HIV research across the care continuum, which includes multiple clinical trials and implementation science projects in Kenya. Dr. Mugo has been the PI of two studies, one, looking to strengthen the viral load monitoring for children and adolescents by identifying gaps in the monitoring cascade and their solutions using failure mode and effect analysis, and two, a longitudinal study on patterns and effect of self-disclosure of HIV status by adolescents and young adults living with HIV. Nelly Rwamba Mugo, MBCH, MMED (Ob,Gyn), MPH: Senior Principal Clinical Research Scientist KEMRI Dr. Mugo is a reproductive health specialist with three decades of work experience. Her research focus has been on prevention of HIV and cervical cancer among other reproductive health research work. She has been an investigator on two landmark clinical trials, the Partners PrEP study that contributed evidence to inform the change of indication for use of Truvada as HIV prevention pre-exposure prophylaxis (PrEP), and a protocol lead for the on-going ‘Kenya Single-dose HPV Vaccine-Efficacy (KEN SHE) Study –’ that has provided evidence on efficacy of single dose HPV vaccination. Dr. Mugo is a member of the International Papillomavirus Society education committee, the Kenya Obstetrics and Gynecology society, and has contributed to several World Health Organization and Kenya ministry of health working group scientific committees. Chris Longenecker, MD. Dr. Longenecker is a non-invasive cardiologist and Associate Professor in the Division of Cardiology and Department of Global Health at the UW School of Medicine. He is the inaugural Director of the Global Cardiovascular Health Program, a joint initiative of cardiology and global health. Clinically, he attends on the Harborview cardiology consultative service and is director of a unique HIV-Cardiology clinic within the Madison Clinic at Harborview. Dr. Longenecker’s research, which is primarily in the USA and Uganda, focuses on mechanisms and prevention of cardiovascular disease in people living with HIV, with a secondary focus on quality of care and outcomes for people living with rheumatic heart disease. Kenneth Mugwanya MBChB, MS, PhD. Dr. Mugwanya is a physician-epidemiologist and an Assistant Professor in the Department of Global Health at the UW. His research focuses on multidisciplinary studies of epidemiology and prevention of HIV and other STIs, implementation science, and antiretroviral PrEP pharmacology in African populations, particularly among young women. Over the past decade, he has led or collaborated on pivotal HIV prevention studies involving >30,000 HIV at-risk participants that have advanced PrEP implementation and HIV prevention for populations in Africa and globally. 3.6 Career development support a. Research work in progress meetings: In addition to weekly meetings with individual mentors and monthly  meetings with mentoring teams, all fellows and mentors will meet quarterly to report on professional  development goals and share research progress. These will be facilitated by Drs. Bukusi and Farquhar. b. Leadership coaching: To enhance research leadership skills, mentees will have monthly scheduled  leadership coaching sessions with Dr. Bukusi. These sessions will help clarify their career trajectory, build  confidence in any areas identified for additional skills building and enable professional development of skills  that are useful for successful career development, including but not be limited to improving self-awareness  and clarification of leadership styles, work life balance, conflict management and negotiating. c. Grant and manuscript writing training: The fellowship with include grant writing and manuscript writing  workshops. The grant writing workshops will be focused on development of K43 and other funding  opportunities. The manuscript writing workshops will include a focus on publishing their MPH and fellowship  research results. d. UW Kenya Research and Training Center (KRTC) seminars: The trainees will also participate in monthly  KRTC seminars offered on Zoom on the third Tuesday of each month. The seminars are held at a time to  prioritize Kenyan participation. Below is a list of selected KRTC seminars this last year:  1. Cardiovascular Health Research and Training in Kenya. UW Global Cardiovascular Health Program,  April 18, 2023.  2. Optimizing COVID-19 Vaccine Uptake Among PLHIV. Nancy Ngumbau, Kenyatta National Hospital,  June 30, 2023.  3. The Kenya Data Protection Act 2019 – What you Need to Know as a Researcher. Antony Kariri, University  of Nairobi, February 27, 2024. 3.7 Timeline We have solicited full proposals from the 4 finalists. These will be submitted by July 30, 2024 and reviewed by the TAC by August 30, 2024. The table below shows the activity timeline for this program. Activities June-Aug 2024 Sept-Nov 2024 Dec 2024-Feb 2025 Full applications solicited, submitted and reviewed X  Two Fellows selected and funds awarded to recipients X  IRB applications and other regulatory paperwork X  Research activities X X Manuscript preparation, oral presentation, and other dissemination activities X Career development activities, including coaching, research in progress, writing workshops and seminars X X X

PI_NAMEs: BUKUSI, ELIZABETH ANNE;FARQUHAR, CAREY  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Advisory Committees;Affect;Africa South of the Sahara;Age;Attention;career development;comorbidity;Complement;Country;design;Doctor of Philosophy;Educational workshop;Eligibility Determination;Ensure;experience;Face;Fellowship;Funding;girls;Goals;Grant;Health;HIV;improved;Infection;Institution;Kenya;Manuscripts;Medical Research;meetings;Mentors;Mentorship;parent project;Parents;peer;Positioning Attribute;Postdoctoral Fellow;Prevalence;programs;Research;Research Institute;Research Personnel;Research Support;research to practice;success;Training;Training Programs;Translational Research;Universities;Washington;Woman;Women's Health;Writing

PROJECT_TITLE: Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research Fellowship


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide mechanistic knowledge about the generation of the optokinetic reflex from the retina to the motor response. Such fundamental knowledge will enable more sensitive diagnosis of nervous system disorders, with the possibility of precisely linking specific OKR characteristics to specific pathology, thus advancing the clinical use of this simple, non-invasive, and evolutionarily conserved reflex.

PI_NAMEs: DUNN, FELICE A (contact);KOLODKIN, ALEX L

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: attenuation;Behavior;behavior influence;Behavioral;cell behavior;Cell Physiology;cell type;Cells;Characteristics;Clinic;Clinical;clinical application;Computer Models;Cues;Dedications;Dependence;Development;Diagnosis;Diagnostic;differential expression;Disease;Environment;Eye;Eye Movements;Functional disorder;ganglion cell;Generations;Genes;Genetic;Goals;Head Movements;Health;Image;improved;Individual;Inferior;insight;Knowledge;Lead;Ligands;Link;loss of function;Maps;Measures;Molecular;Morphology;Motion;Motor;mouse genetics;Nervous System Disorder;nervous system disorder diagnosis;Neurologic;Neurons;Noise;Optics;Organism;Outcome;Output;Pathology;Perception;Physiological;Population;preservation;Process;Property;Public Health;receptor;Receptor Signaling;Reflex action;Research;response;Retina;Role;Sensory;Signal Pathway;Signal Transduction;single cell sequencing;statistics;Stimulus;Structure;Synapses;System;Translating;vestibular system;Vision;Vision Disorders;Visual;Visual System;Work

PROJECT_TITLE: Retinal mechanisms underlying the optokinetic reflex


NIH_SPENDING_CATS: Bioengineering;Data Science;Dissemination and Implementation Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: RELEVANCE (See instructions): This project creates the first-ever knowledge base of Bio Tools and uses multidimensional indicators to assess their impact and adoption in the biomedical ecosystem. The new indicators of Bio Tool impact, particularly measures of reach and disease impact, advance the state-of-the-art in scientometrics, and the results contribute to our understanding of how Bio Tools diffuse along research trajectories in the biomedical ecosystem and what factors drive success, establishing a foundation for future research.

PI_NAMEs: BARABASI, ALBERT-LASZLO  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: SoS: BIO: Evaluating the Impact of Biomedical Tools and Methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 GDB-T (SP)]


ADMINISTERING_IC: CE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed research is highly relevant to public health due to its potential to advance research on preventing the commercial sexual exploitation of children (CSEC). The current study evaluates a promising prevention education program being implemented in Minnesota using rigorous randomized controlled trial evaluation methodology informed by a Community Based Participatory Research (CBPR) approach. Given that there is little evaluation to guide best practice for CSEC prevention efforts, we expect results from this study to directly inform community efforts in this area of public health.

PI_NAMEs: JONES, LISA M (contact)

PROJECT_TITLE: CE22-003 - A Randomized Controlled Trial Evaluation of the Not a Number Program to Prevent the Commercial Sexual Exploitation of Children (CSEC) and Youth in Minnesota


ORG_CITY: MELROSE

ORG_NAME: CENTER FOR VIOLENCE PREVENTION RESEARCH, INC.

ORG_STATE: FL

PHR: PI: BRIGHT Project Narrative Page 1 of 1 PROJECT NARRATIVE Using a matched cluster randomized control design and partnership with USA Football (USAF), the proposed study will evaluate a CSA primary prevention strategy, Circles of Safety®. League leadership, staff, and coaches with USAF will be focal participants. Outcomes include CSA among youth athletes served, protective and inappropriate behaviors from coaches & league leaders, as well as knowledge of and perceived ability to identify and address CSA and resource-seeking behavior.

PI_NAMEs: BRIGHT, MELISSA  (contact)

PROJECT_TITLE: CE22-003 - Evaluation of Circles of Safety? for the Primary Prevention of Child Sexual Abuse


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Although the commercial sexual exploitation of children (CSEC) is a serious public safety and health problem in the U.S., we know very little about how to prevent CSEC. The purpose of this study is to further develop, implement, and rigorously evaluate a CSEC prevention program (i.e., READY to Stand [RTS] Curriculum) with racially/ethnically diverse high school students using community-based participatory action research. The project is highly responsive to RFA-CE-22-003 and is consistent with the mission of the NCIPC and Healthy People 2030 Objective to reduce violence against adolescents.

PI_NAMEs: EDWARDS, KATIE M (contact)

PROJECT_TITLE: CE22-003 - Rigorous Evaluation of the READY to Stand Curriculum as a Tool to Prevent the Commercial Sexual Exploitation of Children Among Racially and Ethnically Diverse Urban Youth


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Menopause;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative. More research is needed in Uganda to understand optimal ways to prevent and treat HIV and associated comorbidities across women's lifespans, but research capacity is still limited. Building on existing partnerships between Makerere University (MU), its affiliated HIV programs and the University of California, San Francisco, we have established a pioneer implementation science (ImS) Research Training Program at MU, built a strong foundation for ImS in Uganda, and influenced practices along the cascade of HIV care. The Program focus of this supplement is to catalyze research and training on the health impact of HIV on women living with HIV in Uganda.

PI_NAMEs: KAMYA, MOSES ROBERT (contact);SEMITALA, FRED C

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;aging population;Alcohol consumption;antiretroviral therapy;care outcomes;career;Caring;Collaborations;Complex;design;Environment;Epidemic;Face;Health;HIV;HIV/AIDS;implementation science;Infrastructure;interest;Intervention;intimate partner violence;Lead;Leadership;life span;Menopause;Mentorship;next generation;Perimenopause;Persons;Population;Prevention;programs;Research;Research Personnel;Research Training;Resource-limited setting;Resources;response;scale up;Symptoms;Training;Training Programs;transmission process;Uganda;Universities;Viral;Woman;Women's Health;Work

PROJECT_TITLE: Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in Uganda


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Older adults need transportation options that maximize their physical activity and social participation, regardless of disability status. This research will inform future planning and policy by highlighting components of accessible public transit systems which are associated with physical activity and social participation among older adults with disabilities. The knowledge gained will inform whether accessible and inclusive public transit options are a potential avenue to maximize health equity among older adults with disabilities.

PI_NAMEs: TWARDZIK, ERICA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accelerometer;Adult;Affect;Age;Aging;aging in place;Area;Automobile Driving;Award;Behavior;beneficiary;career;career development;Cognition;Communication;Communities;Complex;Data;data integration;Data Sources;density;Development;disability;Disability status;Disabled Persons;Disparity population;Elderly;end of life;Environment;Equity;Facility Designs;Family;Fellowship;Foundations;Friends;Future;Goals;Health;Health behavior;health determinants;health disparity;health equity;Health Status;healthy aging;Hearing;Home;human old age (65+);improved;Intervention;Investigation;Knowledge;lens;Link;longitudinal analysis;Measures;Mediating;Mediation;Medicare;Mentorship;mortality;Neighborhoods;older adult;Pathway interactions;Patient Self-Report;Persons;Phase;Physical activity;Physical shape;Policies;Population;Population Group;Population Heterogeneity;Positioning Attribute;Quality of life;Reduce health disparities;Religion;Reporting;Research;Research Personnel;Role;Sampling;Self Care;Services;social;social engagement;social epidemiology;social health determinants;Societal Factors;structural determinants;Surveys;System;Testing;Training;Transportation;transportation access;Travel;trend;Universities;Urban Developments;urban planning;Visit;Walking;Work

PROJECT_TITLE: Investigating the role of public transit on health behaviors among older adults with disabilities

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Brain rhythms coordinate the activities of millions of neurons for complex cognitive functions, such as learning and memory. We will dissect the circuit mechanisms that generate and route the theta rhythm (4-12 Hz) – one specific brain rhythm critical for memory processing. Our systematic functional mapping of theta-related circuits connecting the hypothalamus and the hippocampus will provide insights into how aging affects brain rhythm coordination and have translational implications for improving memory function in Alzheimer’s disease.

PI_NAMEs: CHEN, SHUO  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;age related changes;age related neurodegeneration;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease model;Anatomy;Animal Diseases;Animals;Area;Attenuated;Biological Models;Brain;Cell Nucleus;Cells;Cephalic;Chronology;Code;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive reserve;Complex;computational neuroscience;Data;Data Analyses;Deep Brain Stimulation;dentate gyrus;Dentate nucleus;Electrophysiology (science);Episodic memory;frontier;Genetic;Goals;Hippocampus;Histologic;Hypothalamic structure;Impaired cognition;improved;in vivo;Individual;insight;Learning;Link;Maps;Medial;Memory;Memory impairment;memory process;Mentors;minimally invasive;Modeling;Modernization;molecular pathology;mouse model;Mus;Nature;neural;Neurobiology;Neurodegenerative Disorders;Neurons;neuroregulation;optogenetics;Pathway interactions;Performance;Phase;Physiological;Physiology;Play;Population;prevent;resilience;Risk;Role;Route;Science;Scientist;Shapes;Signal Transduction;spatial memory;Structure;success;targeted treatment;Techniques;Technology;Testing;Theta Rhythm;Training;Transgenic Organisms;translational impact;Work;young adult

PROJECT_TITLE: Elucidating circuit mechanisms of brain rhythms in the aging brain


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This Pathway to Independence Award focuses on leveraging advanced artificial intelligence approaches and large-scale electronic health records (EHR) to study antecedent risk factors for subjective cognitive decline (SCD) and dementia outcomes in SCD. Specifically, machine learning and natural language processing techniques and statistical methods will be used to identify pre-dementia and presumed SCD study cohorts in a large EHR, analyze social and clinical characteristics for potential risk factors for SCD, and predict the risk of dementia progression in SCD. Research results gleaned from these analyses using large, longitudinal EHR data will advance the understanding of the antecedents and outcomes of SCD in EHR, which has the potential to improve the process of participant selection and enrollment in clinical trials and thereafter early interventions for Alzheimer’s disease and related dementias.

PI_NAMEs: WANG, LIQIN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;Age;Agreement;Algorithms;Alzheimer's disease related dementia;Appearance;Area;Artificial Intelligence;Award;biomedical informatics;Cardiovascular Diseases;case finding;Characteristics;Clinical;clinical epidemiology;Clinical Informatics;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Cohort Studies;Data;Dementia;dementia risk;Development;Diagnosis;Early Diagnosis;Early Intervention;Electronic Health Record;Enrollment;Ensure;Epidemiology;Exclusion;Exclusion Criteria;experience;Factor Analysis;Glean;Goals;Health Personnel;Healthcare Systems;high risk;Impaired cognition;Impairment;Incidence;Individual;Informatics;innovation;insight;Intervention;Investigation;Kidney Diseases;Knowledge;longitudinal analysis;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Measures;Medical;medical attention;Memory Loss;Mentorship;Methods;mild cognitive impairment;multimodality;Natural Language Processing;Neurology;neuropsychiatric disorder;novel therapeutics;observational cohort study;older adult;Outcome;Participant;participant enrollment;Pathway interactions;patient stratification;Patients;Performance;performance tests;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;pre-clinical;Prevalence;Procedures;process improvement;prognostic model;programs;Research;Research Personnel;Respiratory Tract Infections;Risk;Risk Factors;risk prediction;risk prediction model;Sampling;skill acquisition;skills;Sleep Disorders;social;Statistical Methods;Surveys;Symptoms;Techniques;Technology;Testing;tool;Training

PROJECT_TITLE: Antecedents and Outcomes of Subjective Cognitive Decline: An Electronic Health Records and Artificial Intelligence Approach


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The SWI/SNF complex is a critical regulator of gene expression and is frequently mutated in a wide range of human diseases. This complex is combinatorially assembled from approximately 30 genes, yet we don’t understand how these assemblies are regulated or what the consequences are of having different compositions. The goal of this project is to define new mechanisms that regulate chromatin remodeler composition and function.

PI_NAMEs: RAAB, JESSE R. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemical;Chromatin;Chromatin Remodeling Factor;combinatorial;Complex;Development;Disease;functional outcomes;Gene Expression;Gene Expression Regulation;Genes;Goals;Human;human disease;insight;Malignant Neoplasms;Mediating;Molecular;mutant;Mutate;novel strategies;novel therapeutics;Outcome;Play;Positioning Attribute;Post-Translational Protein Processing;Regulator Genes;RNA;Role;SWI/SNF Family Complex;tumor;Variant

PROJECT_TITLE: Mechanisms of SWI/SNF complex assembly and function

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: RIVERSIDE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE Much of the human head is formed from neural crest cells and abnormalities during neural crest cell development can lead to congenital craniofacial and neurological defects and cancers including melanoma. Preliminary data suggests that the precise location of RNAs within individual neural crest cells or their derivatives can affect behavior of the cell. This project will elucidate the fundamental principles regulating the location and function of these RNAs within cells, and causally link RNA localization to developmental and cancer-related outcomes.

PI_NAMEs: NORRIS, MEGAN L (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Advisory Committees;Affect;Attention;Award;Biological Assay;cancer genetics;career;Catalogs;cell behavior;cell motility;Cell Physiology;cell type;Cells;Co-Immunoprecipitations;collaborative environment;Congenital Abnormality;craniofacial;Data;Defect;design;Development;Diagnosis;Disease;Elements;Embryonic Development;Environment;experience;experimental study;falls;gain of function mutation;Galium;Genes;Genetic Engineering;Genetic Transcription;Goals;Head;Human;Image Analysis;In Vitro;in vivo;Individual;insight;interest;Intervention;Invaded;Kinesin;light microscopy;Link;Location;loss of function;Malignant Neoplasms;Mammalian Cell;melanocyte;Melanoma;Melanoma Cell;Mentorship;Messenger RNA;migration;Modeling;Molecular;Motor;mouse model;Mus;Mutation;Neural Crest;Neural Crest Cell;Neurologic;Neurons;novel;Outcome;Pathway interactions;Phenotype;Physiological;Physiology;Post-Transcriptional Regulation;posttranscriptional;Prevention;Process;programs;protein function;protein protein interaction;Proteins;Regulation;Research;Resources;RNA;Role;Route;Running;Schwann Cells;single molecule;System;Techniques;Technology;Testing;Time;Tissues;Total Internal Reflection Fluorescent;trafficking;Training;Trans-Activators;Transcription Process;transcriptomics;Translations;tumor progression

PROJECT_TITLE: Regulation and function of subcellular RNA localization in neural crest cells and their derivatives


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: DOVER

ORG_NAME: COSMYC INC

ORG_STATE: DE

PHR: PROJECT NARRATIVE The goal of this project is to develop new cancer therapeutics that work by blocking the activity of the MYC oncogene. We have developed a revolutionary drug discovery platform that, for the first time, has enabled the screening and identification of promising small molecules that directly inhibit the cancer-promoting function of MYC. We will perform a series of in vitro and in vivo assessment of these hits to determine their suitability for progression towards a clinically relevant, novel, highly MYC-specific, and safe cancer therapy, which currently does not exist.

PI_NAMEs: FERIS, ED  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: 3-Dimensional;Amides;Attenuated;Awareness;Binding Sites;Biological Assay;Biological Sciences;Biology;Businesses;Cancer Biology;Cancer cell line;cancer therapy;Capital;cell growth;Cell Proliferation;Cellular biology;Climate;clinical development;Clinical Drug Development;clinically relevant;commercialization;Data Science;Development;Down-Regulation;drug discovery;experience;Funding;Future;Gene Targeting;Genes;Genetic Transcription;Goals;Grant;Growth;high throughput screening;Human;In Vitro;in vivo;Individual;Industry;inhibitor;innovation;Innovation Corps;insight;Laboratories;Lead;Ligand Binding;Lymphoma;Malignant Neoplasms;MAX gene;Medicine;meter;Molecular;Molecular Biology;mouse model;MYC gene;novel;Oncoproteins;overexpression;Phase;pre-clinical;prevent;programs;protein protein interaction;Proteins;Research;screening;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Specificity;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Training;Transactivation;transcription factor;tumor growth;United States National Institutes of Health;Validation;Work;Xenograft procedure

PROJECT_TITLE: Therapeutic Inhibition of MYC:TRRAP Interaction in Cancer (I-Crops Supplement)


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

PI_NAMEs: MCCORMICK, DAVID L. (contact)

PROJECT_TERMS: Canis familiaris;Mus;Pharmaceutical Preparations;Rattus;Recovery;Toxic effect;Toxicology;Work

PROJECT_TITLE: TOXICOLOGY STUDIES IN MICE AND DOGS ADMINISTERED MTX-531


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The rapid expansion of the aging ethnic/racial and linguistic minority population is outstripping the capacity to offer disability prevention services necessary to respond to their needs. The proposed renewal project aims to test the effectiveness and implementation readiness of an enhanced mental health and physical disability prevention intervention, delivered by community- based staff in four languages. If proven effective, we will develop a dynamic toolkit to accelerate its dissemination and implementation.

PI_NAMEs: ALEGRIA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Age;Aging;Area;Caring;Client;Clinic;Clinical;clinical research site;Clinical Services;Collaborations;Communities;community building;community clinic;Community Health Aides;community organizations;community setting;Consolidated Framework for Implementation Research;cultural competence;design;disability;Disability prevention;disability risk;Disparity;Dissemination and Implementation;dosage;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Elderly;Elements;emotional distress;Enrollment;Environment;ethnic minority population;Ethnic Origin;evidence base;Evidence based treatment;Exercise;Feedback;Florida;frailty;Funding;Geographic Locations;Grant;Health Professional;help-seeking behavior;human old age (65+);implementation barriers;implementation evaluation;implementation process;Implementation readiness;Improve Access;improved;Individual;innovation;interest;Intervention;intervention participants;Language;learning community;Limited English Proficiency;Linguistics;Maintenance;Massachusetts;Mental Depression;Mental disability;Mental disorders;Mental Health;Mental Health Services;Mind;Minority;Minority Groups;Modeling;Mood Disorders;mood symptom;National Institute of Mental Health;Neighborhoods;New Agents;New York;Not Hispanic or Latino;novel;older adult;Older Population;Outcome;Participant;Patients;Persons;Phase;Physical activity;physically handicapped;Population;prevention service;preventive intervention;programs;Provider;psychoeducation;Puerto Rico;Race;racial minority population;Recurrence;reduce symptoms;Reporting;Research;Resource-limited setting;Resources;Risk;self reliance;Services;Severities;Site;social stigma;Source;Spanish;substance use;success;Testing;Therapeutic;Training;treatment research;uptake;Work

PROJECT_TITLE: Building Community Capacity for Disability Prevention for Minority Elders

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Evaluation of SeMaglutide as an Adjunct to buprenorphine treatment for the treatment of opioid use disorder: A pragmatic Randomized placebo-controlled Trial (SMART) PROJECT NARRATIVE The present study is a multi-site, randomized placebo controlled pragmatic trial with the primary objective of evaluating the impact of semaglutide, relative to placebo, as an adjunct to BUP on substance use outcomes with illicit opioid use and on retention in treatment. While it is expected that semaglutide will be more effective as an adjunct than as a mono-therapy for OUD, the BUP dropout that will naturally occur during the trial provides the opportunity to explore the feasibility of, and collect some efficacy data on, the provision of semaglutide, relative to placebo, in individuals discontinuing BUP. The exploratory aim is to compare substance use outcomes and opioid-related overdoses for the semaglutide and placebo groups in individuals discontinuing BUP.

PI_NAMEs: WINHUSEN, T JOHN (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: Abate;Affinity;analog;Buprenorphine;buprenorphine treatment;craving;Data;Dropout;Enrollment;Epidemic;Evaluation;glucagon-like peptide 1;illicit opioid;Individual;mortality;Non-Insulin-Dependent Diabetes Mellitus;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Persons;Placebo Control;placebo group;Placebos;pragmatic trial;primary outcome;Public Health;Randomized;randomized placebo controlled trial;receptor binding;Site;Stimulant;stimulant use;stimulant use disorder;stimulant user;substance use;therapeutic target;treatment effect;Weight maintenance regimen

PROJECT_TITLE: CTN -  Evaluation of SeMaglutide as an Adjunct to buprenorphine treatment for the treatment of opioid use disorder: A pragmatic Randomized placebo-controlled Trial (SMART)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Assistive Technology;Atherosclerosis;Bioengineering;Cardiovascular;Diabetes;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Intervention of many cardiovascular diseases requires bypassing or replacing blood vessels. The current gold standard is the autograft, which causes donor site morbidity and often has limited supplies. The goal of this project is to test a redesigned biodegradable synthetic graft that can transform into an artery-like conduit in situ in preclinical animal models.

PI_NAMEs: TZENG, EDITH ;WANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acceleration;Address;Affect;age effect;aged;Aging;Animal Model;Architecture;Arteries;Arteriovenous fistula;artery occlusion;Atherosclerosis;Autologous;Autologous Transplantation;Automobile Driving;biodegradable scaffold;Biological;Bioreactors;Blood flow;Blood Vessels;Bypass;Caliber;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;cell motility;Cells;Clinical;clinical translation;comorbidity;controlled release;Coronary;cost;cytokine;Data;Deposition;design;Development;Devices;Diabetes Mellitus;diabetic;Diameter;effectiveness evaluation;Elasticity;elastomeric;Elastomers;Elderly;endothelial stem cell;Extracellular Matrix;Fiber;Goals;graft failure;graft function;Harvest;Human;Immune response;Impairment;Implant;improved;In Situ;infection risk;Infiltration;Inflammation;insight;Interleukin-10;Intervention;Kidney Failure;Knee;Knowledge;Limb structure;Modeling;Morbidity - disease rate;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Operative Surgical Procedures;Pathology;patient population;Patients;Performance;pre-clinical;Process;Property;Proteins;Rattus;reconstruction;Research;Rodent;Route;scaffold;Sheep;Site;Source;Speed;Sprague-Dawley Rats;stem cell population;Stromal Cells;Systemic disease;Technology;Testing;Tissues;Vascular Graft;Vein graft;wound healing

PROJECT_TITLE: Elastic, Degradable Vascular Grafts with Helical Microfibers

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Many diseases are linked to the abnormal function of proteins or the macromolecular complexes or machines into which they assemble. My laboratory uses structural biology to interrogate both these machines and machines that are capable of editing genes associated with diseases. By analyzing these structures, we will learn the fundamentals of how they work and how to alleviate their dysfunction that leads to disease states.

PI_NAMEs: TAYLOR, DAVID W (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Architecture;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;Cryoelectron Microscopy;Disease;Foundations;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;genome editing;Genome engineering;Image;insight;interest;Label;Laboratories;Learning;Link;Macromolecular Complexes;Molecular;Molecular Conformation;Negative Staining;Production;protein function;Proteins;Research Personnel;Site;structural biology;Structure;tool;Translational Research;Work

PROJECT_TITLE: Imaging macromolecular machines in gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Live discharge from hospice presents particularly profound challenges to end-of-life (EoL) care of patients with Alzheimer's disease and related dementias (ADRD) due to their complex EoL conditions and symptoms, highly uncertain prognosis, and difficulty in communicating EoL care preference. Despite two recent policy changes, live discharges from hospice remain persistently high among ADRD patients. This proposed mixed-methods study aims to provide novel evidence for patient-centered EoL care delivery of ADRD patients who are discharged alive from hospice by characterizing and predicting patient trajectories in care transition, functional decline, and healthcare utilization after hospice live discharge.

PI_NAMEs: ZHANG, YONGKANG  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: accountable care organization;adverse outcome;Affect;aggressive therapy;Alzheimer's disease related dementia;behavioral health;beneficiary;care coordination;care delivery;care preference;Caregivers;Caring;Cessation of life;Clinical;Communication;comorbidity;Complex;Confusion;Counseling;Data;Data Set;Diagnosis;Discharge Plannings;Disease;Distress;Electronic Health Record;end of life;end of life care;end of life outcomes;Ensure;Ethnic Origin;experience;Fee-for-Service Plans;follow-up;frailty;functional decline;Future;Goals;Growth;Health;health care service organization;health care service utilization;Heterogeneity;high risk;Home;Hospice Care;hospice environment;hospice utilization;Human Resources;Impaired cognition;improved;Informatics;Intensive Care;Interview;Leadership;Link;machine learning method;machine learning model;Marketing;Medicare;Medicare claim;Methods;model development;Modeling;multiple chronic conditions;National Institute on Aging;novel;older adult;Outcome;Pain management;Patient Care;patient oriented;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;payment;Performance;personalized intervention;Physicians;Policies;predictive modeling;Process;Prognosis;programs;Provider;Race;Recommendation;Reporting;Research;Socioeconomic Status;Structure;symptom management;Symptoms;System;tool;Validation;Visit

PROJECT_TITLE: Characterizing and Predicting Patient Trajectories After Live Discharge from Hospice among Older Adults with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-D(90)S]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;HIV/AIDS;Human Genome;Prevention;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE This project will provide advanced training in the conduct of research in an understudied area: the impact of HIV and antiretroviral treatment on menopause and on birth outcomes in older women with HIV. As women living with HIV age, this is a population that is increasingly important in the global HIV epidemic, but about which little is known. The results of these research projects are expected to contribute to mentee training and to generate preliminary data that will catalyze the career development of two promising trainees, such that they continue research on the health of older women living with HIV.

PI_NAMEs: LOCKMAN, SHAHIN ;MAKHEMA, JOSEPH MOEKETSI;SHAPIRO, ROGER L (contact)

PROJECT_TERMS: adverse pregnancy outcome;age group;Birth;Botswana;career development;Clinical Trials;Databases;Genomics;Goals;Grant;Health;HIV;improved;Incidence;interest;Laboratory Research;Menopause;Mentors;older women;Outcome;Parents;Persons;Population;Pregnancy;Records;Research;Research Infrastructure;Research Project Grants;Training;training opportunity;Training Support;Woman;Women's Health

PROJECT_TITLE: Training in HIV Genomics, Treatment, and Cure Research in Botswana


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: Project Narrative The proposed ITN UM1 funding addresses major unmet health needs. In the United States, autoimmune diseases, including T1D, affect >5% of the population. Pre-clinical studies show that immune tolerance should be an achievable therapeutic prospect, and progress towards that goal is evident in recent clinical trials and the resulting mechanistic work. Successful tolerance offers long-term freedom from immunosuppressive therapy, radically improving quality of life, disease burden, and health care costs. 1 Abstract

PI_NAMEs: ANDERSON, MARK S;BUCKNER, JANE HOYT (contact)

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Area;Autoimmune Diseases;burden of illness;California;clinical application;Clinical assessments;Clinical Research;clinical research site;Clinical Trials;design;Development;Discipline;Disease;Freedom;Funding;Future;Genetic;Goals;Health;Health Care Costs;Immune Tolerance;Immunologics;Immunology;improved;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interest;Knowledge;Laboratories;Lead;Leadership;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;Population;preclinical study;Process;programs;Quality of life;Research Institute;Research Personnel;Role;San Francisco;Structure;Therapeutic;Therapeutic immunosuppression;treatment response;trial planning;United States;Universities;Work

PROJECT_TITLE: Immune Tolerance Network-NIDDK 2024 Supplement


ADMINISTERING_IC: DE

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Nanotechnology;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PUBLIC HEALTH RELEVANCE Priming approaches activating innate immune sensors, which constitute the first step of generating tumor- specific immunity, have emerged as appealing methods to sensitize non-responsive head and neck cancers to immune checkpoint receptor blockade immunotherapy. However, many of these priming approaches are challenged by emerging resistance whose mechanism is poorly understood and few strategies are available for cancers that escape from innate immune sensors. This innovative program will leverage our recent discoveries of central regulators of the innate immune sensors to engineer a robust nanoparticle system with a strong promise in overcoming cancer resistance to innate immune priming therapies.

PI_NAMEs: LEI, YU LEO (contact);MOON, JAMES J.

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Agonist;analysis pipeline;Antigen-Presenting Cells;Beds;Biochemical;cancer cell;Carcinogens;Cells;checkpoint receptors;Clinical;Competence;Complex;Cross-Priming;Cytoplasm;Dependence;Dinucleoside Phosphates;DNA;DNA Repair;DNA Replication Induction;Effectiveness;Effector Cell;effector T cell;Endoplasmic Reticulum;Engineering;Epithelial Cells;fitness;Funding;Gene Activation;gene induction;gene translocation;Generations;Genes;Genetic Engineering;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Hematopoietic;Human;Human papillomavirus 16;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune Tolerance;Immunity;immunogenicity;Immunotherapy;Implant;improved;Individual;innate immune sensing;innovation;Interferon Activation;Interferon Type I;Interferons;Intraepithelial Neoplasia;irradiation;Lead;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Membrane;Metabolic;Methods;Modeling;Molecular;Mus;Mutation;Myeloid Cells;Nanodelivery;nanoparticle;nanoparticle delivery;Nanotechnology;novel;Oncogenes;oral cavity epithelium;Pathway interactions;Patients;Performance;Periodicity;Phosphorylation;Phosphorylation Site;Physiological;Prevention;Preventive;Production;programs;public health relevance;Recurrence;replication stress;Resistance;Resolution;response;RNA;Role;sensor;Shapes;Signal Transduction;single cell technology;Solid Neoplasm;Specimen;Stains;Stimulator of Interferon Genes;synergism;System;T-cell inflamed;T-Cell Receptor;T-Lymphocyte Subsets;Therapeutic;Time;Tissue Microarray;trafficking;Translating;tumor;Tumor Antigens;Tumor-infiltrating immune cells;Unresectable;γδ T cells

PROJECT_TITLE: Restoring the Immunogenicity of Head and Neck Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Congenital Heart Disease;Epilepsy;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: It is critical to use a clinically-relevant model and to take a multi-system approach when developing drugs to treat the pathologies associated with genetic ion channelopathies of the brain and heart. In people, KCNH2 variants are linked to a high risk of epilepsy, sudden unexpected death in epilepsy (SUDEP), arrhythmias, and Long QT Syndrome Type 2 (LQT2). As there are no established anti-seizure medications for LQT2 patients with epilepsy, we will demonstrate that our new translational model of Kcnh2-mediated epilepsy, SUDEP, and LQT2 will facilitate future neurotherapeutic discovery and testing.

PI_NAMEs: AUERBACH, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Animal Model;Anticonvulsants;Arrhythmia;Biological Assay;Brain;Cardiac;Cause of Death;cell type;Clinical;clinically relevant;CRISPR/Cas technology;Data;Development;Drug Modelings;drug testing;Epilepsy;Face;Family member;Frameshift Mutation;Future;Genetic;genetic variant;Genotype;Heart;Heterozygote;high risk;Human;in vivo;Ions;Link;Long QT Syndrome;Mediating;Membrane Potentials;Modeling;Muscle Cells;Neurons;Oryctolagus cuniculus;Pathology;patient registry;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenytoin;Potassium Channel;Proteins;Research;Rest;Risk;Rodent;Rodent Model;screening;Seizures;Sudden Death;sudden unexpected death in epilepsy;System;Testing;translational model;translational study;Type 2 Long QT syndrome;Validation;Variant

PROJECT_TITLE: Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Pediatric

ORG_CITY: RENO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Program Director/Principal Investigator (Last, First, Middle): HOY, JENNIFER, LYN PROJECT NARRATIVE This work will identify neural circuit mechanisms underlying the development of visual stimulus detection and pursuit behavior. Appropriately orienting towards salient stimuli and filtering out distraction is required for healthy visual cognition and attention in adults and is sensitive to developmental experience. Autism, schizophrenia, ADHD and generalized anxiety are disorders rooted in perturbed development and are associated with deficits in the ability to properly modulate visuospatial orienting behavior.

PI_NAMEs: HOY, JENNIFER LYN (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Adolescent;Adult;Age;age related;age related changes;Animals;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior change;Behavioral Assay;Biological Assay;Calcium;Cell Physiology;cell type;Cells;Complex;Data;density;Detection;Development;developmental disease;Disease;distraction;early experience;Electrophysiology (science);Environment;experience;extracellular;Freezing;Frequencies;Generalized Anxiety Disorder;Genes;Genetic;Goals;Image;in vivo;Individual;Insecta;interest;Knowledge;Learning;Life;Link;Location;LYN gene;Mammals;Measures;Mediating;Modification;mouse model;Mus;Nervous System Disorder;neural;neural circuit;neural patterning;Neurodevelopmental Disorder;Neurons;novel;optogenetics;Output;Pathway interactions;Pilot Projects;Play;Population;Post-Traumatic Stress Disorders;postnatal;Primates;Principal Investigator;Process;programs;response;Retina;Role;Schizophrenia;Sensory;Site;Space Perception;Speed;Stimulus;Structure;superior colliculus Corpora quadrigemina;Synapses;targeted treatment;Time;tool;Ultrasonography;ultrasound;virtual reality environment;Virus;vision development;Visual;Visual attention;visual cognition;visual information;Visual Perception;visual plasticity;visual processing;visual stimulus;Visual System;Visuospatial;Work

PROJECT_TITLE: Experience-Dependent Plasticity in Superior Colliculus and Natural Visual Behavior

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

PHR: PROJECT NARRATIVE The NIAID-funded Allergy and Asthma Statistical and Clinical Coordinating Center (AA-SCCC) provides a broad range of support for research in allergic diseases and asthma, including for the following major clinical research programs: the Atopic Dermatitis Research Network (ADRN), Consortium for Food Allergy Research (CoFAR), Childhood Asthma in Urban Settings Clinical Research Network (CAUSE), and Immune Tolerance Network (ITN). These networks currently lack a platform accessible to the public for showcasing their projects and disseminating their valuable findings. This additional funding would establish a public-facing website for the AA-SCCC that will enable the supported networks to exhibit their ongoing studies, actively promote study recruitment, spotlight successful outcomes, and share findings with the broader community.

PI_NAMEs: DAVID, GLORIA ;VISNESS, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Advocate;Allergic Disease;Area;Asthma;Atopic Dermatitis;Autoimmune Diseases;Autoimmunity;Award;Budgets;Charge;Childhood Asthma;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;Computer software;Consultations;Contractor;cost;COVID-19 booster;Custom;Dedications;design;Development;Diagnosis;digital;Elements;Ensure;Exhibits;expectation;Extrinsic asthma;Food Hypersensitivity;Funding;Government;Home Page;Human Resources;Hypersensitivity;Immune Tolerance;Information Networks;Internet;Investigator-Initiated Research;Link;Maintenance;Mission;Names;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;Outcome;parent project;Pathogenesis;Phase;Prevention;programs;prototype;recruit;remediation;Research;Research Project Grants;Research Support;Resources;rho;Self-Help Devices;Services;Site;Support Contracts;support network;System;Testing;Update;urban setting;Vendor;web services;web site;Work

PROJECT_TITLE: RhoFED AA-SCCC


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: /PROJECT NARRATIVE Globally 232 million or 50% of people, with type 2 diabetes mellitus are unaware and undiagnosed leading to an increased number of serious end-organ complications and a large associated healthcare economic burden. Our prior studies demonstrated that increased deltoid muscle echo intensity (increased brightness) on ultrasound was accurate for the detection of type 2 diabetes as well as prediabetes and corresponded to skeletal muscle insulin resistance and muscle dysfunction. We aim to clarify this ultrasound skeletal muscle abnormality which could serve as a clinically feasible, novel, easy, noninvasive, nonionizing, and inexpensive method to detect developing skeletal muscle insulin resistance and muscle dysfunction, as a precursor of developing type 2 diabetes, allowing earlier interventions and more aggressive treatments for metabolic and muscle dysfunction, prior to these complications accelerating.

PI_NAMEs: SOLIMAN, STEVEN B (contact)

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Abnormal Hemoglobins;Acceleration;Adult;adult obesity;Affect;Age;aggressive therapy;Beta Cell;Biopsy;Blood capillaries;Clinical;Clinical Markers;cohort;Communities;Cross-Sectional Studies;Defect;deltoid muscle;density;Deposition;Detection;Development;Diabetes Mellitus;Diagnosis;Disease Progression;Early Diagnosis;Early identification;Early Intervention;Economic Burden;effective therapy;Evaluation;Expenditure;experimental study;Failure;Fiber;Fibrosis;Functional disorder;Glucose;Glycogen;Glycosylated hemoglobin A;Guidelines;Health;health care economics;Histologic;Histology;Hour;human subject;illness length;imaging modality;improved;indexing;Inflammatory;Insulin;Insulin Resistance;Life Style Modification;Lipids;Lower Extremity;Measurement;Measures;Metabolic;Metabolic dysfunction;Methods;mitochondrial dysfunction;mortality;mouse model;Muscle;musculoskeletal ultrasound;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Non-Invasive Detection;novel;Obesity;OGTT;Organ;Outcome;Patients;Persons;Prediabetes syndrome;prevent;prospective;Publications;quadriceps muscle;Quality of life;quantitative ultrasound;reduced muscle strength;Research;Research Design;Risk;Risk Reduction;Sampling;Signal Pathway;Skeletal Muscle;socioeconomics;Testing;Time;treatment optimization;Ultrasonography;ultrasound;United States;United States Preventative Services Task Force;Update;Upper Extremity

PROJECT_TITLE: Early Type 2 Diabetes Detection with AI-Analysis of Skeletal Muscle Ultrasound and Mechanistic Evaluations

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Animals;Bayesian Method;Cattle;Dairying;dashboard;Data;Data Discovery;Disease Outbreaks;Ensure;Evolution;Farm;Genbank;Genomics;Human;Individual;Influenza A Virus, H5N1 Subtype;insight;Intelligence;Milk;Monitor;Mutation;National Institute of Allergy and Infectious Disease;pandemic disease;pandemic potential;Pathogenicity;Phenotype;Phylogenetic Analysis;Population;Process;repository;Risk;Sampling;Sequence Read Archive;Source;System;Systems Biology;Time;transmission process;United States;Viral;Virus;Work

PROJECT_TITLE: Center for Viral Systems Biology- H5N1 Supplement


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: STAATS, HERMAN  (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adjuvant;Allergens;Allergic Disease;Animal Model;Animals;Antigens;Autoimmune Diseases;Basic Science;Biological Assay;Cells;clinically relevant;Collaborations;Communicable Diseases;Communities;Contractor;Data;data management;Development;Disease;Disease Outcome;End Point Assay;Fingerprint;Future;Goals;Human;Immune;Immunity;Immunologics;In Vitro;in vivo;Innate Immune Response;Ligands;Measures;National Institute of Allergy and Infectious Disease;novel vaccines;pathogen;Peptides;programs;Protocols documentation;research and development;Side;Site;Standardization;Tissues;TLR4 gene;TLR7 gene;vaccine development;Vaccines;Work

PROJECT_TITLE: Adjuvant Comparison and Characterization of Peanut Antigen


ORG_NAME: PREVENT CHILD ABUSE AMERICA

ORG_STATE: IL

PHR: Project Narrative This proposal is responsive to Research Priority 3 by cataloguing and rigorously evaluating state policies (i.e., school-based CSA education laws and other relevant policies) associated with the prevention of CSA. In Component A (i.e., Years 1 and 2), we will form a research- practice-policy partnership (RPPP) (Aim A1), with researchers, policy experts, CSA professionals, and those with lived expertise with CSA, to inform a state-by-state policy landscape assessment (Aim A2) and scoping review of the scientific literature (Aim A3) on the topic of CSA prevention policies. In Component B (i.e., Years 3 through 5), we propose to rigorously evaluate school-based CSA education laws (Aim B1) and their variation (Aim B2) as well as examine other CSA policies (Aim B3) across states on reports and substantiations for CSA and other forms of child maltreatment.

PI_NAMEs: KLIKA, JEFFRY BART (contact);MERRICK, MELISSA T

PROJECT_TITLE: Evaluation of the effects of child sexual abuse prevention policies on adult perpetrated child sexual abuse


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BUFFALO

ORG_NAME: STARKS ASSOCIATES, INC.

PI_NAMEs: MIDDLETON, MARK  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Basic Science;Biological;Clinical Trials;co-infection;Collaborations;Communities;Contracts;Development;Devices;Extramural Activities;Hepatitis B Virus;Hepatitis C virus;HIV;In Vitro;in vivo evaluation;Investigational New Drug Application;Investigator-Initiated Research;Licensure;Mycobacterium tuberculosis complex;National Institute of Allergy and Infectious Disease;novel therapeutics;pathogen;pre-clinical;Private Sector;product development;repository;Research;research clinical testing;research study;Resources;Services;Therapeutic;therapeutic development;United States Food and Drug Administration;Work

PROJECT_TITLE: Conduct Synthesis and Acquire Batches of Compounds for Subsequent Biological In Vitro and In Vivo Testing


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY R (contact)

PROJECT_TERMS: Antigens;Clinical Trials;Contractor;Contracts;data management;Databases;Development;Documentation;efficacy study;Equipment and supply inventories;HIV vaccine;HIV-1;Human;Human Resources;immunogenicity;In Vitro;Infrastructure;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;National Institute of Allergy and Infectious Disease;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;Reporting;research clinical testing;Shipping;stability testing;Testing;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: NIAID Preclinical Development Support: Essential Core Activities