ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Applying an accelerated follow-up design we will test whether and how social isolation contributes to the health challenges of individuals with schizophrenia-related disorders as they age. This study may show that in SZ socialization in midlife can reduce the risk for poor health outcomes and ultimately facilitate much-needed preventive targeted therapies to reduce early-age mortality in SZ.

PI_NAMEs: REICHENBERG, ABRAHAM  (contact);VELTHORST, EVA

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;Age;age acceleration;age difference;age related;Age Years;Aging;Antipsychotic Agents;Behavior;Biological Markers;Body mass index;Characteristics;Clinical;Cognition;cohort;comorbidity;Country;COVID-19;COVID-19 pandemic;Data;Death Rate;Depressed mood;design;Diagnosis;Diet;digital phenotyping;Disabling;Disease;Environment;Ethnic Origin;Ethnic Population;Europe;Exhibits;follow-up;General Population;Goals;Government;Health;health data;health difference;human old age (65+);Individual;Life;life span;Loneliness;longitudinal database;longitudinal design;Measures;Medical;medical examination;Medical Records;Mental Depression;middle age;mortality;Natural experiment;neuropsychiatry;older adult;Outcome;Participant;Patients;Pattern;physical conditioning;physical inactivity;Physically Challenged;Physicians;poor health outcome;post-pandemic;premature;Premature Mortality;prevent;Preventive;Process;Psychotic Disorders;Race;racial population;Research;Resources;Risk;Risk Factors;Risk Reduction;SARS-CoV-2 exposure;Schizophrenia;secondary analysis;Severity of illness;sex;Siblings;Smoke;Smoking;social contact;Social isolation;Social Network;Socialization;Stress;Subgroup;symptomatology;Symptoms;targeted treatment;Testing;Time;Unhealthy Diet;unhealthy lifestyle;Vulnerable Populations;Work

PROJECT_TITLE: The impact of social isolation on aging health in schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Lung;Pediatric;Prevention

ORG_CITY: COLLEGE STATION

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project 2 Narrative Children living near Superfund sites are at high risk for inhalation exposures to hazardous volatile organic compounds (VOCs), especially following environmental disasters. Since mechanisms underlying the role of VOCs in asthma pathogenesis are poorly understood, this project will develop an age-appropriate, population- based in vitro pediatric airway model to rapidly characterize respiratory risks and determine the role of extracellular vesicles in response to VOC exposure. Using a state-of-the-art mobile air sampling approach, we will also characterize ambient VOC mixtures in high-risk communities to support real-world toxicity testing and disaster research response.

PI_NAMEs: JOHNSON, NATALIE M (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Age;Air;air monitoring;Air Pollution;air sampling;airway epithelium;Apical;Area;Asthma;Atlases;Atmosphere;Biomedical Research;bronchial epithelium;Cell Line;Cell model;cell type;Cells;Chemicals;Child;Child Health;Childhood;Coculture Techniques;Collaborations;Communities;Data;Data Set;design;detection method;Development;Disasters;Elements;Emergency Situation;Environment;Epithelial Cells;Epithelium;Evaluation;Event;Exhibits;exosome;experimental study;Exposure to;extracellular vesicles;Fire - disasters;gas analyzer;Genetic;hazard;Hazard Identification;Hazardous Substances;Health;high risk;Homeostasis;Human;Hurricane;improved;In Vitro;in vitro Model;in vivo;Individual;individual variation;Inflammation;Inhalation Exposure;Injury;irritation;Laboratories;Life;Liquid substance;Location;Lung;lung injury;mass spectrometer;Measurement;Mediating;Methods;mobile computing;Modeling;Molecular;Monitor;Morphology;Neighborhoods;novel;Outcome;Outcome Study;Pathogenesis;Pathologic;Pattern;Permeability;Phenotype;Physicians;Population;population based;potential biomarker;Predisposition;preservation;Prevention;Process;programs;protein expression;Proteins;Proteome;Proteomics;Protons;Race;Reaction;Research;Research Project Grants;Resources;Respiration Disorders;respiratory;respiratory health;response;response to injury;Risk;Risk Assessment;Role;Sampling;Science;Scientist;sex;Signal Transduction;Superfund;superfund site;Surface;Testing;Texas;three-dimensional modeling;time use;tool;Toxicity Tests;training opportunity;Translating;Translational Research;Universities;volatile organic compound;Work

PROJECT_TITLE: Project 2


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Chronic kidney disease (CKD) affects more than 35 million Americans and can progress to complete kidney failure, a condition in which patients must undergo kidney dialysis or transplantation for survival. Veterans are more likely to have CKD compared to the general population, and the prevalence of CKD among veterans is rising. When CKD is accompanied by the abnormal excretion of proteins in the urine (known as proteinuria or albuminuria), the risk of developing complete kidney failure is greatly increased. Treatments for this type of CKD are extremely limited and are intended to slow disease progression rather than cure the disease. This application tests the specific effects of a major cellular pathway (Nrf2) on proteinuric CKD in order to develop more effective treatments for this disease in the veteran population.

PI_NAMEs: TAN, RODERICK JASON (contact)

PROJECT_TERMS: Adriamycin PFS;adverse outcome;Affect;Albuminuria;American;analog;Angiotensin II;Animal Model;Animals;Antioxidants;Basement membrane;Biological Models;Biology;Cardiovascular Diseases;Cell Differentiation process;Cell Proliferation;cell type;Cells;Cellular Stress;Chronic;Chronic Kidney Failure;Clinic;Clinical Trials;clinically relevant;conditional knockout;Consumption;Cytoprotection;Data;Diabetes Mellitus;Diabetic Nephropathy;Dialysis procedure;Disease;Disease Progression;Dose;Drug Metabolic Detoxication;effective therapy;End stage renal failure;Endothelial Cells;Endothelium;Enhancers;Etiology;Excretory function;Experimental Models;Exposure to;Fibrosis;Focal and Segmental Glomerulosclerosis;Foot Process;Functional disorder;GATA1 gene;General Population;Genes;Genetic;glomerular filtration;Glomerular Filtration Rate;glomerulosclerosis;Goals;Health;Health Care Costs;Hereditary nephritis;High Prevalence;Human;human disease;improved;Individual;inhibitor;Injury;Injury to Kidney;interstitial;Kidney;kidney cell;Kidney Failure;Kidney Transplantation;Knock-out;Knockout Mice;Malignant Neoplasms;Mediator;military veteran;Modeling;mouse model;Mus;nuclear factor-erythroid 2;Nuclear Translocation;Pathologic;Pathway interactions;Patients;pharmacologic;Play;podocyte;Population;preclinical study;Prevalence;Proteins;Proteinuria;Reactive Oxygen Species;Renal dialysis;Renal glomerular disease;Repression;restraint;Risk;Role;single nucleus RNA-sequencing;Testing;Therapeutic;Time;transcription factor;trigonelline;Tubular formation;United States Department of Veterans Affairs;Up-Regulation;urinary;Urine;Veterans;Wild Type Mouse;Work

PROJECT_TITLE: The Role of Nrf2 in Proteinuric Chronic Kidney Disease


NIH_SPENDING_CATS: Biotechnology;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: Project 3 NARRATIVE Exposures to environmental hazardous substances, including those that may be released in the event of natural and anthropogenic disasters, are known to impact pregnancy, leading to adverse pregnancy outcomes like preterm birth. Here, we propose to address our central hypothesis that a tissue chip model mimicking the complex multi-cellular feto-maternal interface can be used to evaluate the mechanistic pathophysiologic pathways related to preterm birth that may be perturbed by complex mixtures of environmental hazardous substances. We will also develop and utilize a higher throughput tissue chip model that can rapidly assess the potential hazard of environmental samples that may lead to preterm birth.

PI_NAMEs: HAN, ARUM  (contact)

PROJECT_TERMS: 37 weeks gestation;Address;adverse outcome;adverse pregnancy outcome;Affect;Aging;Animal Model;anthropogenesis;Cells;Chemicals;Child;Clinical;Clinical Research;Coculture Techniques;Collaborations;Complex;Complex Mixtures;cost;Data;Data Analyses;data management;Decidua Basalis;decidua parietalis;detection method;Disasters;Emergency Situation;Environmental Exposure;Environmental Hazards;Environmental Impact;Environmental Monitoring;Environmental Pollutants;Epidemiology;Evaluation;Event;Exposure to;fetal;Fetal Membranes;Fetal Tissues;Fetus;Future;Hazard Assessment;Hazardous Chemicals;Hazardous Substances;Health;Health Hazards;Homeostasis;Human;Immune Tolerance;improved;in utero;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Intervention;Kinetics;Knowledge;Link;Measures;Membrane;Methods;Modeling;neonatal morbidity;Neonatal Mortality;novel;Oxidative Stress;Pathway interactions;Physiology;Placenta;potential biomarker;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;remediation;Research;response;Risk;Risk Assessment;Risk Reduction;Sampling;Science;senescence;Side;Structure;success;Superfund;superfund site;System;Technology;Testing;Texas;therapeutic target;Tissue Microarray;Tissues;tool;Toxic effect;Toxic Environmental Substances;toxicant;Toxicity Tests;Toxicokinetics;Toxicology;Universities;Uterus;Vulnerable Populations;Work

PROJECT_TITLE: Project 3


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: ROLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Glaucoma remains the second leading cause of blindness worldwide. We will investigate a three-pronged strategy to reduce intraocular pressure by reducing aqueous humor production and promoting outflow promotion through the trabecular meshwork and uveoscleral pathways. The new formulation based on this novel therapeutic intervention will be clinically impactful for improving glaucoma treatment and patient adherence.

PI_NAMEs: LIU, XIAORONG ;YANG, HU  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adrenergic Agonists;Adrenergic beta-Antagonists;Adult;ANGPT1 gene;anterior chamber;anti-glaucoma drug;aqueous;Aqueous Humor;Artificial nanoparticles;Behavioral;Betaxolol;Biological Assay;Biological Availability;Blindness;Brimodine;Carbonic Anhydrase Inhibitors;Characteristics;Clinical;Combined Modality Therapy;Cornea;Dendrimers;design;Dose;Drainage procedure;Drug Delivery Systems;Drug Formulations;Effectiveness;Electroretinography;Excision;Eye;Formulation;Foundations;Frequencies;Glaucoma;Hydrogels;Impairment;improved;in vivo;kinase inhibitor;Kinetics;Label;liquid chromatography mass spectrometry;Long-Term Effects;mass spectrometric imaging;Mediating;mouse model;Mus;nanoparticle;nanoparticulate;Nanostructures;near infrared dye;novel therapeutic intervention;particle;Pathway interactions;Patient Compliance;Pharmaceutical Preparations;Pharmacotherapy;Physiologic Intraocular Pressure;Production;Prostaglandins;Research;Resistance;Retina;Rho-associated kinase;Risk Factors;Route;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;System;Testing;Therapeutic;Time;Tissues;Trabecular meshwork structure;treatment adherence;treatment duration;Visual Acuity;Wild Type Mouse;Work

PROJECT_TITLE: Modulating aqueous humor outflow with engineered nanoparticles for glaucoma

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project 4 NARRATIVE Project 4 will determine what cell-based human model systems best predict potential toxicity, including the extent of inter-individual and inter-tissue variability, in people who may be exposed to hazardous substances as a result of a disaster. We will also create a framework for testing mixtures of chemicals for toxicity in these cell-based systems and for how best to understand at what dose these mixtures may be harmful. The outcome of this project will be a set of experimental tools and computational models that can be used rapidly during/after natural or man-made disasters.

PI_NAMEs: RUSYN, IVAN  (contact)

PROJECT_TERMS: Address;Analytical Chemistry;Biological;Biological Availability;Biological Models;Biomedical Engineering;Cardiac Myocytes;Case Study;Cell Line;Cells;Chemicals;Collaborations;Communities;community engagement;Complex;Computer Models;Consumption;Data;Data Analyses;data management;design;detection method;Disasters;Dose;Emergency Situation;Environmental Exposure;Environmental Hazards;Environmental Monitoring;Equipment;Ethnic Origin;Evaluation;Event;evidence base;experimental study;Exposure to;first responder;Funding;Future;Genome;Goals;Government;hazard;Hazardous Substances;Health;health assessment;Health Hazards;high dimensionality;high throughput screening;Human;human induced pluripotent stem cells;human model;Image;In Vitro;in vitro Model;in vivo;in vivo evaluation;Individual;inter-individual variation;International;Knowledge;Life;liver metabolism;lymphoblast;man-made disasters;Maps;Metabolism;Methodology;Methods;Modeling;Molecular;Mus;novel;novel strategies;organ on a chip;Outcome;Parameter Estimation;Persons;Physiological;Population;population based;Population Sizes;Race;Renal clearance function;Reproducibility;Research;Resources;response;Risk;Risk Assessment;Safety;Sampling;Science;sex;Site;Source;Specificity;Study models;Superfund;superfund site;System;Techniques;Testing;Texas;Time;Tissue Microarray;Tissues;tool;tool development;Toxic effect;Toxicokinetics;Translational Research;Translations;Universities;Work

PROJECT_TITLE: Project 4


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: RELEVANCE TO PUBLIC HEALTH Elevated plasma triglyceride levels are associated with an increased risk for atherosclerotic heart disease, and severe forms of hypertriglyceridemia often lead to life-threatning pancreatitis. We will pursue discoveries on basic mechanisms for triglyceride metabolism with advanced biochemical and imaging techniques (including NanoSIMS imaging); simultaneously, we will pursue our discovery of a new human metabolic disease syndrome (chylomicronemia from GPIHBP1 autoantibodies) and test whether plasma GPIHBP1 levels are a useful biomarker for metabolic or vascular disease.

PI_NAMEs: YOUNG, STEPHEN G. (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;atherosclerosis risk;Autoantibodies;Autoimmune;Biochemical;Biological Assay;Biological Markers;Biology;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;Cells;cellular imaging;Chemicals;Clinical Medicine;Complex Mixtures;Coronary Arteriosclerosis;Coronary heart disease;Disease;disorder risk;Electrons;Endothelial Cells;Fatty Acids;Frequencies;Gene Expression;Gene Expression Profiling;Genes;Health;Heart;high resolution imaging;Human;Hypertriglyceridemia;Image;imaging approach;Imaging Techniques;interstitial;Intravenous;Ions;Isotopes;Label;Laboratories;Life;lipid metabolism;lipid transport;Lipids;Lipolysis;Lipoprotein Binding;lipoprotein lipase;Lipoproteins;Mediating;Metabolic Diseases;Methods;Molecular;Monoclonal Antibodies;Morphology;Movement;Mus;Nutrient;Pancreatitis;Patients;Plasma;Positioning Attribute;preservation;Process;Proteins;Public Health;Reagent;Role;Site;Syndrome;Testing;Textbooks;Tissue imaging;Tissues;Triglyceride Metabolism;Triglycerides;Vascular Diseases;Visualization

PROJECT_TITLE: Investigating Mechanisms for Lipid Transport in Health and Disease


NIH_SPENDING_CATS: Bioengineering;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Project 5 NARRATIVE This project is developing broad-activing sorbent materials that can be used to minimize exposures to hazardous chamicals during and after environmental and man-made disasters. The outcomes of this project will be of direct use by first responders, frontline personnel, vulnerable community members, and others exposed to hazardous chemical substances during disasters and emergencies. Ultimately, the strategy of using multicomponent sorbents and novel barrier formulations will effectively decrease chemical exposures through ingestion, dermal contact and inhalation.

PI_NAMEs: PHILLIPS, TIMOTHY  (contact)

PROJECT_TERMS: absorption;Address;Affinity;Air;Amendment;Animals;Area;Binding;Biological;Biological Assay;Biological Availability;Biological Models;Caenorhabditis elegans;Chemical Exposure;chemical reduction;Chemicals;Cnidaria;Collaborations;Communities;community collaboration;community engagement;Competence;Computing Methodologies;contaminated water;Data Analyses;data management;Dermal;dermal exposure;design;Development;Dimensions;Disasters;dosimetry;drinking water;Drug Metabolic Detoxication;efficacy validation;Emergency response;Emergency Situation;Engineering;Ensure;Environment;environmental chemical;Environmental Science;Event;experience;experimental study;Exposure to;face mask;Feedback;first responder;Food;Food Contamination;Food Supply;Formulation;Frontline worker;Funding;Goals;Hazardous Chemicals;Hazardous Substances;Human;in silico;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;Ingestion;Inhalation;Inhalation Exposure;insight;Kinetics;Legal patent;Licensing;Life;man-made disasters;manufacture;Masks;member;Methodology;Methods;Minor;Modeling;molecular dynamics;Natural Disasters;Neighborhoods;Nematoda;novel;Organism;Outcome;Pathway interactions;Persons;Plants;Play;Pollution;Process;Production;Property;Reaction;Recreation;Research;Research Personnel;response;Risk;Role;Safety;Sampling;Science;Site;Skin;Soil;Source;success;Superfund;superfund site;Surface;Technology;Technology Transfer;Testing;Thermodynamics;tool;Toxic effect;Training;Translational Research;Translations;uptake;vulnerable community;Vulnerable Populations;Water;Water Supply;Work

PROJECT_TITLE: Project 5


PHR: Administrative & Research Translation Core NARRATIVE The Administrative & Research Translation Core is providing leadership and guidance to the Texas A&M University Superfund Research Center. It provides general Center malmanagement support, promotes cross- discipline interactions among all projects and cores, and facilitates research translation. The Core operates through regular Center-wide and project-specific meetings, tracks the productivity of the Center, develops future activities, and guides scientific innovation through a pilot project program. The Core also coordinates the Center’s disaster research response (DR2) activities, training, community engagement and outreach with input from two advisory committees.

PROJECT_TERMS: Academia;Address;Advisory Committees;Biological Sciences;Collaborations;college;commercialization;Communication;Communities;community engagement;Community Outreach;community partners;Data;data sharing;Decision Making;Development;Disasters;Discipline;Educational workshop;effectiveness evaluation;Emergency Situation;Ensure;Environment;Environmental Impact;Environmental Pollution;Evaluation;Event;Exposure to;Faculty;Feedback;Future;Geography;Goals;Government;Government Agencies;hazard;Health;Health Hazards;Human;improved;in vitro testing;Industry;innovation;Institution;Leadership;man;meetings;Modeling;Monitor;National Institute of Environmental Health Sciences;Nongovernmental Organizations;Output;outreach;Performance;Pilot Projects;practical application;Private Sector;Productivity;Program Evaluation;programs;Protocols documentation;Public Sector;Publications;Qualifying;quality assurance;Reporting;Research;Research Activity;Research Project Grants;response;risk prediction;Software Tools;Superfund;support tools;System;Technology;Technology Assessment;Technology Transfer;Texas;tool;Training;Training Activity;Translating;translational goal;translational potential;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative and Research Translation Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Urologic Diseases;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE As demand for PFD care continues to grow, high-quality, collaborative research is critically needed. Brown/WIH is committed to actively participating in the PFDN and conducting high-impact research that will guide prevention and clinical management and lead to new discoveries in the field of PFDs.

PI_NAMEs: SUNG, VIVIAN W (contact)

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: Abdomen;Adoption;Advocacy;Age;Aging;Bioinformatics;Biological Markers;Caring;Clinical;clinical care;Clinical Management;clinical research site;Clinical Trials;Collaborations;Colorectal Surgery;community engagement;Community Outreach;Data Analyses;data quality;Dedications;design;Discipline;Education;Ensure;Federally Qualified Health Center;Female;Gastroenterology;Guide prevention;Health;Health system;Healthcare Systems;Hospitals;improved;Individual;Infant;Infrastructure;innovation;Institution;interdisciplinary approach;Journals;Leadership;Manuscripts;member;Memory;microbiome;minority communities;minority engagement;Minority Groups;minority health;Mission;Monitor;multidisciplinary;National Institute of Child Health and Human Development;New England;new technology;Operative Surgical Procedures;Outcomes Research;outreach clinics;outreach program;patient oriented;Patient-Focused Outcomes;Patients;Pelvic Floor Disorders;Peroxisome Proliferator-Activated Receptors;Physical therapy;Population;Population Heterogeneity;Positioning Attribute;Preparation;Productivity;programs;protocol development;Protocols documentation;Publications;Qualifying;Quality of Care;Radiology Specialty;recruit;regenerative approach;regenerative tissue;Research;Research Infrastructure;Research Personnel;Resources;Rhode Island;Robotics;Safety;Science;Scientific Advances and Accomplishments;Site;study population;Time;Tissue Engineering;Underrepresented Populations;Urology;Vagina;Woman;Women's Health;Work

PROJECT_TITLE: Brown/WIH Pelvic Floor Disorders Network Site


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Prevention;Social Determinants of Health

PHR: Community Engagement Core NARRATIVE The residents of communities located along the Galveston Bay/Houston Ship Channel (GB/HSC) region have excess risk of exposure to acute pollution, emergency chemical spills and incidents, and high-impact natural disasters, such as hurricanes and flooding. Community engagement provides a link between the adaptive capacities of a community—the human, fiscal, political, and social resources that enable proactive behavior— and its responses and changes after disruptions, including natural disasters and environmental contamination events. An engaged community has greater resilience and is better able to anticipate future threats and prepare for and recover from adverse events.

PI_NAMEs: NEWMAN, GALEN  (contact)

PROJECT_TERMS: Acute;Address;Adverse event;Advocacy;Air;anthropogenesis;Area;Behavior;Biological;chemical disaster;chemical incident;chemical spill;Chemicals;citizen science;Communication;Communities;community based research;community center;community engaged research;community engagement;Community Health;community involvement;community organizations;community partners;Coupled;crowdsourcing;Data;Data Analyses;Data Collection;data management;Data Set;Detection;Development;Disasters;Educational workshop;Emergency Situation;Environmental Hazards;Environmental Health;environmental justice;Environmental Pollution;Environmental Risk Factor;Evaluation;Event;evidence base;Evidence based intervention;experience;Exposure to;Face;Faculty;Fire - disasters;Floods;Fostering;Future;Generations;Geographic Information Systems;Growth;hazard;Hazard Identification;Hazardous Chemicals;Hazardous Substances;Health;high school;Human;Hurricane;improved;Inequity;Infrastructure;Inhalation;Intervention;Knowledge;Link;man;member;Methods;Modeling;multidisciplinary;Natural Disasters;Neighborhoods;Outcome;Play;Policies;Politics;Pollution;Prevention;Prevention strategy;promote resilience;Public Participation;Regulation;Research;Research Design;Research Personnel;resilience;Resources;response;Risk;Risk Assessment;Role;Sampling;Schools;Science;science education;Services;social;social vulnerability;Soil;Students;Superfund;Testing;Texas;tool;Toxic effect;toxicant;Training;Translating;Translational Research;Translations;Trust;Universities;Water;Work

PROJECT_TITLE: Community Engagement Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diseases of the respiratory system and of critical illness constitute major public health problem in the US and worldwide. The objective of this Program is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory disease and critical illness. We expect that trainees from this Program will identify disease mechanisms and develop and implement new effective treatments that will improve human health.

PI_NAMEs: FANG, YUN ;MUTLU, GOKHAN M. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Biology;Research Training;respiratory

PROJECT_TITLE: Research training in respiratory biology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Prevention

PHR: Research Experience and Training Coordination Core (RETCC) NARRATIVE The Center brings together a team of scientists from biomedical, geosciences, data science, and engineering disciplines to design comprehensive solutions for complex exposure- and health hazard-related risk assessment and reduction challenges. Given the diversity of the disciplines involved, the excellence of the investigators, and the tight integration of the fundamental and applied research, the Center will form an outstanding training environment for graduate students and postdoctoral fellows and will create ample opportunities for integration and professional development of our trainees. The Research and Experience Training Coordination Core promotes interdisciplinary learning via collaborative projects across multiple Projects/Cores; augments trainees’ existing graduate and postdoctoral programs with targeted skill-building workshops; provides opportunities for interactions with diverse audiences (scientific and layperson); and tracks and evaluates trainee development and success.

PI_NAMEs: BRINKMEYER-LANGFORD, CANDICE L. (contact)

PROJECT_TERMS: Academia;Address;Affect;Applied Research;Award;biomedical scientist;career;Certification;Chemical Exposure;Chemicals;cohesion;Collaborations;Collection;Communities;community engagement;community research;Complex;Complex Mixtures;Data;Data Analyses;Data Collection;data management;Data Science;Decision Making;design;Detection;Development;Disasters;Discipline;Distance Learning;doctoral student;Economics;Educational process of instructing;Educational workshop;Emergency response;Emergency Situation;Engineering;Environment;Environmental Health;environmental toxicology;Event;experience;Exposure to;externship;Faculty;first responder;fundamental research;Funding;Geoscience;Goals;Government;graduate student;Growth;hazard;Hazard Assessment;Hazardous Chemicals;Hazardous Substances;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;Health Hazards;Health protection;improved;Industry;innovation;Institution;Interdisciplinary Education;International;Knowledge;Learning;Legal;Legal patent;Measures;meetings;Methods;Modeling;multidisciplinary;National Institute of Environmental Health Sciences;next generation;Persons;Postdoctoral Fellow;programs;Protocols documentation;Public Health;Publications;Records;remediation;Reporting;Research;Research Personnel;Research Support;response;Risk;Risk Assessment;Risk Reduction;Safety;sample collection;Science;Scientist;Signal Recognition Particle;Site;skills;social;success;Superfund;Taiwan;Texas;tool;tool development;Toxicology;Training;training opportunity;Training Programs;Translational Research;Translations;Universities;Update;Work


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Home health is an ideal post-acute setting for people living with Alzheimer's Disease and Related Dementias (ADRD), yet, people with ADRD experience barriers to accessing needed health care services. Unprecedented changes in home health in 2020 due to pandemic disruption and implementation of a new reimbursement model pose a significant threat to home health access and quality for people with ADRD. This study examines the impact of these changes on home health access and quality of care for people with ADRD and will inform advocacy efforts, current home health practice, and future post-acute care health policy.

PI_NAMEs: KNOX, SARA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acute;acute care;Admission activity;Advocacy;Affect;aging in place;Alzheimer's disease related dementia;Behavioral Symptoms;beneficiary;billing data;care costs;career development;Career Mobility;Caring;Characteristics;Clinical;college;Communities;comparison group;Competence;Complex;cost;COVID-19;COVID-19 pandemic;Data;Data Analyses;Doctor of Philosophy;economic implication;Equilibrium;Ethics;experience;functional decline;Funding;Future;Goals;Grouping;Health;health care service;Health Occupations;Health Policy;health practice;Health Services Research;Healthcare Systems;Home;Home Care Services;Home Health Agency;hospital readmission;Hospitalization;Individual;Institution;Institutionalized Persons;International;Length;Link;Matched Group;Measures;Medical;Medicare;member;Mentors;Mentorship;Methods;Modeling;Observational Study;older adult;operation;Outcome;Outcome Measure;pandemic disruption;patient population;Patient Preferences;Patient risk;Patients;payment;Persons;Physical therapy;Policies;Professional Competence;professor;psychological symptom;Qualifying;Quality of Care;Quality of life;Research;Research Design;Research Personnel;Research Training;Resources;Risk Factors;Scoring Method;Services;skills;Source;South Carolina;Stress;System;Techniques;Training;trend;Universities;Vulnerable Populations;waiver

PROJECT_TITLE: Potential New Barriers to Home Health Access for People with Alzheimer's Disease and Related Dementias

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Data Management and Analysis Core (DMAC) NARRATIVE The Data Management and Analysis Core of the Texas A&M Superfund Research Center serves as a hub for translating the raw experimental data produced by the Research Projects into useful knowledge to the community via data collection, integration, quality control, analysis, and model generation. The Core utilizes state-of-the-art methods in data science, optimization and machine learning, develops and applies novel dimensionality reduction techniques, and establishes a common data management and computational platform for collaboration within the Center and data dissemination to the Center stakeholders.

PI_NAMEs: PISTIKOPOULOS, EFSTRATIOS  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Algorithms;Analysis of Variance;Area;Benchmarking;Bioinformatics;Biological;Calibration;Chemical Exposure;Chemicals;Childhood;Classification;Code;Collaborations;Communities;community engagement;Complex;complex data;computational platform;Computer Analysis;Computer software;cytokine;Data;data access;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data dissemination;data management;Data Management Resources;data platform;data quality;data repository;Data Science;Data Science Core;Data Set;data sharing;data standards;data visualization;Deposition;Descriptor;Detection;detection method;dimension reduction;Dimensions;Disasters;Documentation;Educational workshop;Elements;Emergency Situation;Ensure;Environmental Hazards;Evaluation;Event;experience;Experimental Designs;exposure pathway;Exposure to;FAIR principles;feature selection;Frequencies;Funding;Generations;Hazardous Substances;Health;Human;Human Resources;In Vitro;Individual;Inflammatory;Infrastructure;insight;interoperability;ion mobility;Knowledge;Libraries;Lung;Machine Learning;Mass Spectrum Analysis;Mathematics;Measurement;Measures;member;Metadata;Methodology;Methods;Modeling;nonlinear regression;novel;Online Systems;organ on a chip;Outcome;Output;Pattern;Performance;Population;predictive modeling;Pregnancy;Procedures;Protocols documentation;Publications;quality assurance;Quality Control;Recipe;Regression Analysis;Research;Research Personnel;Research Project Grants;respiratory;response;Risk;Sampling;Science;screening;Secure;Services;shared repository;Spectrometry;Statistical Data Interpretation;Statistical Methods;Superfund;System;Techniques;Testing;Texas;tool;toxicant;Toxicokinetics;Training;transcriptomics;Translating;Translational Research;Universities;web platform;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Transcription, a process by which RNA polymerase (RNAP) converts the information stored in the DNA (or RNA) into an RNA message, is critical to the survival of all organisms. The speed with which RNAP makes RNA determines the three-dimensional shape into which RNA folds and consequently whether or not the RNA product can be used for downstream gene expression processes; however, our understanding of the interplay between RNAP kinetics and co-transcriptional RNA folding is lacking. In the proposed project, we will develop novel tools for capturing structural snapshots of RNA folding intermediates and apply them to study RNA folding and function in bacteria and human mitochondria, with ultimate insights into the underlying causes of mitochondrial diseases and applications in engineering microbes for synthetic biology, diagnostic, and therapeutic applications.

PI_NAMEs: MISHANINA, TATIANA VLADIMIROVNA (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Bacteria;Binding;Cells;Communities;Coupling;Diagnostic;Disease;DNA;DNA Sequence;DNA-Directed RNA Polymerase;Engineering;Equilibrium;Event;Gene Expression;Gene Expression Process;Genetic Transcription;Human;insight;interest;Interruption;Kinetics;Link;Maps;Microbe;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial RNA;Molecular;Mutate;Mutation;novel;Nucleic Acids;Nucleotides;Organism;Outcome;Oxidative Phosphorylation;Pathway interactions;Process;Production;programs;Proteins;Research;RNA;RNA chemical synthesis;RNA Folding;Shapes;small molecule;Speed;synthetic biology;Temperature;Testing;Therapeutic;Time;tool;Transcriptional Regulation;Transfer RNA;Variant;Visualization

PROJECT_TITLE: Mechanism of transcription and related gene expression processes in bacteria and human mitochondria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The proposed studies will have important implications for the management of patients with diabetes and metabolic syndrome, in whom the risk of premature cardiovascular disease remains a serious threat. The investigations will provide important and interrelated insights into novel fundamental mechanisms of diabetic vascular disease, which in the long-term will set the stage for the development of new therapeutic agents and pharmacological strategies designed to prevent and interrupt the devastating complications of diabetes.

PI_NAMEs: BORNFELDT, KARIN E. (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Address;Affect;analytical tool;ANGPTL3 gene;Apolipoproteins;Applications Grants;Area;atherogenesis;Atherosclerosis;atherosclerosis risk;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Chylomicrons;Complement;Complications of Diabetes Mellitus;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;diabetic cardiomyopathy;Doctor of Philosophy;dyslipoproteinemia;effective intervention;Ensure;fatty liver disease;Fertilization;Generations;Genes;Glucose;glucose metabolism;Goals;Hepatic;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Hypertriglyceridemia;Impairment;Inflammatory;insight;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Interruption;Investigation;Knowledge;LDL Cholesterol Lipoproteins;Lesion;Link;lipid metabolism;Lipids;Lipolysis;lipoprotein lipase;Lipoproteins;Low-Density Lipoproteins;Macrophage;Metabolic;Metabolic syndrome;Metabolism;Methods;mouse model;Myeloid Cells;Nature;New York;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;particle;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Phospholipid Transfer Proteins;Population;premature;prevent;Prevention strategy;Production;Productivity;Program Research Project Grants;programs;Prospective Studies;Proteins;Proteomics;Regulation;Research;Research Personnel;Residual state;Risk;synergism;Testing;Therapeutic Agents;Therapeutic Intervention;Triglyceride Metabolism;Triglycerides;Universities;Very low density lipoprotein;Washington

PROJECT_TITLE: Triglycerides, Diabetes and Cardiovascular Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: Risk and Geospatial Sciences Core (RGSC) NARRATIVE The Risk and Geospatial Sciences Core will support the Center in synthesizing, mapping, and visualizing relevant scientific data and conclusions for use by those involved in decisions related to risk management. These services will support the Center’s overall goal by helping to interpret and translate research project findings into information that can be used by varied stakeholders, from communities to federal and state decision-makers, to assess the human health impact of contaminant exposures after an environmental emergency, and enhance the planning, emergency response, as well as long-term recovery and remediation efforts related to environmental disasters.

PI_NAMEs: CHIU, WEIHSUEH A (contact)

PROJECT_TERMS: Address;built environment;Chemical Exposure;Chemicals;cohesion;Communication;Communities;community engagement;Complex;Coupled;Data;Data Analyses;data management;Decision Making;design;Disasters;diverse data;Economic Models;Emergency response;Emergency Situation;Environmental Impact;Environmental Policy;Environmental Pollutants;Environmental Risk Factor;Event;experience;Experimental Designs;Exposure to;first responder;Funding;Geographic Distribution;Geography;Goals;Government;hazard;Health;Health Hazards;Human;improved;Individual;Infrastructure;Knowledge;long term recovery;Maps;Methods;Modeling;Outcome;Pilot Projects;Population;population based;remediation;Research;Research Project Grants;Research Support;response;Risk;Risk Assessment;Risk Management;Sampling;Science;Service delivery model;Services;Site;sociodemographics;Source;Spatial Distribution;spatiotemporal;Superfund;support tools;Texas;tool;Toxic effect;Toxicokinetics;Training;Translating;Translational Research;Uncertainty;Universities;Visualization;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Risk and Geospatial Sciences Core


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;Atherosclerosis;Bioinformatics;Cardiovascular Diseases;career;Communication;data communication;data portal;data sharing;Diabetes Mellitus;Ensure;Evaluation;Faculty;Fellowship;Funding;Goals;Human;Individual;Institution;Lipoproteins;Location;medical schools;Medicine;meetings;Myeloid Cells;National Heart, Lung, and Blood Institute;next generation;operation;peer;Peer Review Organizations;Principal Investigator;Program Research Project Grants;programs;Proteomics;Regulation;Reporting;Research;Research Personnel;Review Committee;Scientific Evaluation;Scientist;statistics;success;Training;Triglycerides;Universities;Washington;web site

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative: Abnormal swelling and weakness in blood vessels (aneurysms) can be a life-threatening emergency if the aneurysm ruptures. This project identified circulating blood cells called platelets for predicting when an aneurysm may rupture and as targets to treat aneurysms without surgery.

PI_NAMEs: CAMERON, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Abdomen;Abdominal Aortic Aneurysm;Acceleration;Affect;American;Aneurysm;antagonist;Antiplatelet Drugs;Aorta;Aortic Aneurysm;Arteries;Aspirin;Biological Markers;Biomechanics;Biosensor;Blood;Blood Cells;Blood flow;Blood Platelets;Blood Vessels;Cardiovascular Diseases;career;Cause of Death;cerebrovascular;Cessation of life;Chronic;Circulation;Clinical Trials;cohort;Communication;Communities;comorbidity;Coronary Arteriosclerosis;cost;Country;Data;Development;Disease;Elderly;Emergency Situation;Endopeptidases;Engineering;Environment;Enzymes;Event;Exposure to;extracellular;Glycoproteins;Goals;Growth;Health Care Costs;Hospital Mortality;human old age (65+);insight;Intervention;Laboratories;Life;Ligands;Link;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechanics;Mediator;Medical;Membrane;Membrane Proteins;men;mouse model;Mus;novel;olfactory receptor;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;Platelet Activation;Platelet aggregation;platelet phenotype;protein expression;Proteins;rapid detection;receptor;Research Personnel;Risk;Rupture;Ruptured Abdominal Aortic Aneurysm;Ruptured Aneurysm;Surface;surgical risk;Swelling;System;Testing;Therapeutic;thrombotic;Thrombus;Time;Tissue Inhibitor of Metalloproteinase-1;Tissue Inhibitor of Metalloproteinases;Tissues;transcriptomics;United States;Zinc

PROJECT_TITLE: Platelets as Biosensors and Mediators of Aortic Aneurysm Growth

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


PI_NAMEs: VAISAR, TOMAS  (contact)

PROJECT_TERMS: Abbreviations;analytical method;analytical tool;apolipoprotein B-48;Apolipoprotein E;Atherosclerosis;Basic Science;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Calibration;Cardiovascular Diseases;Chylomicrons;Collaborations;Complex;complex data;Concentration measurement;Consultations;cost;cost effectiveness;Data;Data Analyses;Data Set;Data Storage and Retrieval;Databases;Development;Diabetes Mellitus;Diabetic Angiopathies;Disease;Electrospray Ionization;Ensure;Family;Goals;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Human Resources;IDL lipoproteins;Individual;instrument;instrumentation;interest;ion mobility;Isotopes;Label;Laboratories;link protein;Lipoproteins;Liquid Chromatography;liquid chromatography mass spectrometry;Low-Density Lipoproteins;Mass Spectrum Analysis;Measurement;Measures;Metabolism;Methods;Modernization;Molecular;Monitor;mouse model;New York;novel;novel strategies;particle;Pathogenesis;Pathway Analysis;phenotypic data;Physiological;Procedures;Process;program costs;Program Research Project Grants;programs;protein complex;Proteins;Proteome;Proteomics;Reaction;Reproducibility;Research;Research Personnel;Risk Factors;Scientist;Services;Shotguns;Site;Standardization;Systems Biology;Techniques;Technology;tool;Translational Research;translational study;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Core B: Proteomics and lipoprotein characterization core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

PHR: Disaster Research Response (DR2) Core NARRATIVE The Texas A&M University Superfund Research Center is engaged in a number of disaster research response (DR2) activities and deployed personnel to a number of disasters to collect samples and respond to concerns from community partners, non-governmental organizations, and local and state agencies. Activities included sampling of water, sediment, and soils in response to Hurricane Harvey (2017), Hurricane Florence (2018), and the large-scale industrial fire at the Intercontinental Terminals Company (ITC) facility (2019). Therefore, this new DR2 Core will support the Center, and the rigor and reproducibility of its DR2 activities, by ensuring the Center’s ability to respond to disasters through creation of a centralized resource to support DR2 infrastructure, methods, supplies, and training.

PI_NAMEs: MCDONALD, THOMAS JOSEPH (contact)

PROJECT_TERMS: Address;Analytical Chemistry;Basic Science;Catalogs;Certification;Collection;Communities;community engagement;Community of Practice;community partners;Complex;Consultations;Data;Data Analyses;data management;Databases;Decision Making;Dedications;Dependence;design;Dimensions;Disasters;Documentation;Electronics;Emergency Situation;Ensure;Environment;environmental chemistry;Equipment;Event;experience;experimental study;Exposure to;Faculty;Fire - disasters;Freeze Drying;Funding;Future;Hazardous Substances;Hazardous Waste Operations and Emergency Response;Health;Human;Human Resources;Hurricane;improved;Industrialization;Infrastructure;innovation;instrumentation;Laboratories;laboratory equipment;Learning;Life;Measures;method development;Methods;Modeling;Nongovernmental Organizations;Procedures;Process;programs;Protocols documentation;quality assurance;Records;repository;Reproducibility;Research;Resources;response;Risk;Safety;sample collection;Sampling;Science;Services;Site;Soil;Superfund;System;Techniques;Technology;Testing;Texas;Time;Time trend;tool;Training;Translating;translational engagement;Translational Research;Translations;Transportation;United States National Institutes of Health;Universities;water sampling;Work

PROJECT_TITLE: Disaster Research Response (DR2) Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative We will use behavioral, electrophysiological, neuroimaging, and brain manipulation techniques to determine the mechanisms that mediate social competence—the processes that match behavior to the current demands of the social environment and which are often compromised in neuropsychiatric disorders like schizophrenia and diseases like HIV.

PI_NAMEs: HUETTEL, SCOTT ALLEN;PLATT, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adherence;Adopted;Anxiety;Behavior;Behavior Control;Behavioral;Brain;Complex;Computer Models;Data;Decision Making;Dehumanization;Disadvantaged;Discrimination;Disease;Effectiveness;Electrophysiology (science);Elements;Environment;experimental study;flexibility;Grant;Health;health disparity;HIV;HIV Seropositivity;Homologous Gene;Human;improved;Individual;Individual Differences;Link;Mediating;Mental Depression;Mental Health;microstimulation;Modeling;Monkeys;neural;neural model;neuroimaging;neuropsychiatric disorder;nonhuman primate;novel;Outcome;Parietal;Persons;Play;Positioning Attribute;Prefrontal Cortex;Primates;Process;Property;Role;Schizophrenia;Shapes;social;Social Behavior;Social Controls;Social Environment;social exclusion;Social Functioning;social group;Social Hierarchy;Social Perception;social situation;social skills;Social status;Structure of superior temporal sulcus;Support System;Techniques;Testing;theories;Time;Treatment Protocols;Work

PROJECT_TITLE: Mechanisms Regulating Complex Social Behavior

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


PI_NAMEs: KANTER, JENNY E. (contact)

PROJECT_TERMS: analytical method;analytical tool;Aorta;Arterial Fatty Streak;Arteries;Atherosclerosis;Bioinformatics;Biological Assay;Biology;Cardiovascular Diseases;Cell Compartmentation;cell type;Cells;Characteristics;Complement;Confocal Microscopy;cost effectiveness;Data;Data Set;Diabetes Mellitus;Digestion;Ensure;Family;Flow Cytometry;Gene Expression;Gene Expression Profiling;Histologic;histological stains;Histology;immunocytochemistry;Immunohistochemistry;Individual;instrumentation;Laboratories;laser capture microdissection;Lesion;Lesion by Morphology;Lipoproteins;Macrophage;Measurement;Molecular;Morphology;mouse model;Myeloid Cells;novel;Procedures;Process;Program Research Project Grants;programs;Protocols documentation;Regulation;Reproducibility;Research;Research Personnel;RNA analysis;Services;single-cell RNA sequencing;Site;Stains;Standardization;Techniques;Technology;tissue preparation;Tissues;transcriptome sequencing;Triglycerides;Valsalva sinus

PROJECT_TITLE: Core C: Myeloid cell and atherosclerosis core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Skin Cancer

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE While immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have shown unprecedented and durable clinical responses in a variety cancers, resistance to therapy remains a problem for the majority of patients. This project seeks to understand the fundamental mechanisms linking cancer cell mutations that confer resistance to immunotherapy with immunosuppressive myeloid cells infiltrating these tumors. This work will define a new paradigm of personalized immunotherapy to tailor treatment to an individual patient based on their tumor’s mutations and infiltrating myeloid cells.

PI_NAMEs: MILLER, BRIAN C (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Advisory Committees;anti-PD-1;anti-PD1 therapy;Antigen Presentation;Biological Assay;Biopsy;cancer cell;cancer therapy;career development;cell killing;Cell Line;Cells;Cellular biology;Clinical;clinical efficacy;clinical practice;Combination immunotherapy;Combined Modality Therapy;Computational Biology;Dana-Farber Cancer Institute;Data;Data Set;Development;Development Plans;Dissection;Doctor of Philosophy;Educational process of instructing;Effector Cell;Ensure;Environment;Generations;Goals;Heterogeneity;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunologist;Immunosuppression;immunosuppressive macrophages;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;individual patient;individualized medicine;Infiltration;Inflammatory;Laboratory Research;Laboratory Study;Lead;Link;Malignant Neoplasms;Mediating;medical schools;Melanoma;Melanoma Cell;Melanoma patient;mentoring community;Mentors;Mentorship;Modeling;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;neutrophil;novel;novel therapeutics;Oncologist;Patient Care;Patients;Pattern;PD-1/PD-L1;personalized immunotherapy;personalized medicine;Population;prevent;Property;Publishing;Reagent;recruit;Regimen;Research;Research Project Summaries;Resistance;Resistance development;resistance mechanism;resistance mutation;response;Series;Shapes;single cell analysis;single-cell RNA sequencing;skill acquisition;skills;Somatic Mutation;success;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;Time;tool;Training;Translational Research;translational scientist;tumor;tumor growth;tumor immunology;tumor microenvironment;tumor-immune system interactions;tumorigenic;Work

PROJECT_TITLE: Targeting Unique Meyloid Populations to Overcome Anti-PD-1 Resistance Conferred by Specific Cancer Mutations

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PROJECT_TERMS: Acceleration;Address;Affect;ANGPTL3 gene;Antisense Oligonucleotides;Apolipoproteins;Arterial Fatty Streak;Atherosclerosis;atherosclerosis risk;Cardiovascular Diseases;cardiovascular disorder risk;Caspase;Cessation of life;Cholesterol;Cyclic AMP-Responsive DNA-Binding Protein;Data;Data Adjustments;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Event;Exhibits;Health;Hemorrhage;Hepatic;Human;Human Genetics;Hypertriglyceridemia;in vivo;Inflammasome;insight;Insulin deficiency;Insulin Receptor;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;interest;LDL Cholesterol Lipoproteins;Lesion;Lesion by Morphology;Link;Lipids;Lipoproteins;loss of function mutation;Macrophage;Mediating;Metabolic syndrome;Metabolism;Modeling;mouse model;Mus;Mutation;Myeloid Cells;Necrosis;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;particle;Pathway interactions;Patients;Phenotype;Plasma;Prediabetes syndrome;prevent;Prevention strategy;Proteins;Publishing;Receptor Signaling;Residual state;Risk Factors;risk prediction;Role;Serum;Severities;Testing;Time;trait;transcription factor;treatment effect;treatment strategy;Triglyceride Metabolism;Triglycerides;uptake

PROJECT_TITLE: Project 1. Diabetes, triglyceride-rich lipoproteins, and advanced atherosclerosis


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Diabetes;Heart Disease;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: STITZIEL, NATHAN OLIVER (contact)

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Address;Adipose tissue;Alleles;ANGPTL3 gene;Antisense Oligonucleotides;Atherosclerosis;Biological Assay;Biology;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cell Fractionation;Cells;Classification;Co-Immunoprecipitations;Collaborations;Complement;Data;Diabetes Mellitus;Dyslipidemias;Endoplasmic Reticulum;Epidemiology;Exhibits;extracellular;Family;Fasting;Fatty Liver;Genetic Transcription;Glucose;Glucose Clamp;glucose metabolism;glucose production;glucose uptake;Goals;Golgi Apparatus;Health;Hepatic;Hepatocyte;High Density Lipoprotein Cholesterol;high risk;Human;Human Biology;Human Genetics;human induced pluripotent stem cells;Hyperinsulinism;imaging approach;improved;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;Insulin;insulin sensitivity;Insulin Signaling Pathway;Kinetics;LDL Cholesterol Lipoproteins;Lead;Link;Lipase;LIPG gene;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;lipoprotein lipase;lipoprotein triglyceride;Lipoproteins;Liver;loss of function mutation;Low-Density Lipoproteins;Measures;Mendelian randomization;Metabolic;Metabolism;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Oxidoreductase;Participant;particle;Particle Size;Pathway interactions;Patients;pharmacologic;Physiologic pulse;Physiological Adaptation;Plasma;programs;protective effect;Proteins;Proteomics;randomized, clinical trials;recruit;Regulation;Research Personnel;Risk;Risk Reduction;Role;side effect;Skeletal Muscle;subcutaneous;Testing;Therapeutic;therapeutic target;Tissue Harvesting;Tracer;transcriptome;transcriptome sequencing;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Project 2: Regulation of lipid and glucose metabolism by ANGPTL3 in humans


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pleiotropy (the phenomenon where a genetic region or locus confers risk to two or more traits) is widely observed among complex human traits and diseases, including seemingly unrelated traits. While the scientific significance of studying pleiotropy is well-understood, statistical methods for identifying variant-level shared genetic basis of traits in genome-wide association studies (GWAS) are still lacking, especially for family-based studies and studies with partial/complete sample overlap. In this R21 application, we propose to develop novel, powerful and genome-wide scalable methods, along with open-source, user-friendly software, to statistically investigate questions of pleiotropy between complex diseases/traits with or without sample overlap and across the entire allele frequency spectrum using existing aggregate-level genotype-phenotype association results (or GWAS summary statistics) under both population- and family-based study designs.

PI_NAMEs: RAY, DEBASHREE  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Address;Adopted;Area;Autoimmune;Benchmarking;Biological;Biology;Calibration;case control;Case/Control Studies;Collaborations;Communities;Complex;Computer software;Coronary Arteriosclerosis;Craniofacial Abnormalities;Crohn's disease;Data;Data Set;design;Detection;Development;Diagnosis;Disease;drug development;early onset;endophenotype;Ensure;Etiology;Evaluation;Family;Frequencies;Gene Frequency;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Research;genetic testing;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Health;Human;human disease;Human Genome;human subject protection;Individual;innovation;Intervention;Investigation;Knowledge;large scale simulation;Male Pattern Baldness;Malignant neoplasm of prostate;Malignant Neoplasms;Mathematics;Measures;Methodology;Methods;Modeling;Molecular;Molecular Target;Non-Insulin-Dependent Diabetes Mellitus;Normalcy;novel;open source;Parents;Parkinson Disease;Pattern;Phenotype;pleiotropism;Population;Public Health Applications Research;rare variant;Research;Research Design;Research Personnel;Resource-limited setting;Risk;Risk Factors;Sample Size;Sampling;side effect;Signal Transduction;Span 60;Statistical Distributions;Statistical Methods;statistics;Testing;theories;Therapeutic;Tonsillectomy;tool;trait;translational impact;Ulcerative Colitis;user friendly software;user-friendly;Variant

PROJECT_TITLE: Statistical methods for identifying pleiotropy between complex human traits

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


PI_NAMEs: GOLDBERG, IRA J (contact)

PROJECT_TERMS: Adipose tissue;Affect;Angiopoietins;ANGPTL4 gene;Animal Model;Animals;Antisense Oligonucleotides;Aorta;Apolipoproteins;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;Biology;Blood Vessels;Bone Marrow Transplantation;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Characteristics;Cholesterol;Data;Diabetes Mellitus;Diabetic Angiopathies;Diabetic mouse;Diet;Dyslipidemias;Eicosapentaenoic Acid;Endothelial Cells;Fasting;Fatty acid glycerol esters;feeding;Fibrates;Foam Cells;Gene Expression;Generations;Genes;genome wide association study;Glucose;Heterozygote;High Density Lipoproteins;High Fat Diet;Human;human data;hypercholesterolemia;Hyperglycemia;Hyperlipidemia;Hypertriglyceridemia;Impairment;Inflammation;Inflammatory;inhibitor;Insulin;Insulin deficiency;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Investigation;islet;Knock-out;Knockout Mice;Knowledge;Laboratories;laser capture microdissection;Lesion;Leukocytes;Lipids;Lipolysis;lipoprotein lipase;lipoprotein lipase inhibitor;Lipoproteins;Loss of Heterozygosity;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macrophage;magnetic beads;Meta-Analysis;Methods;Modeling;monocyte;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Omega-3 Fatty Acids;particle;Pathogenesis;Patients;Plasma;prevent;Process;programs;Proteins;Regulation;repaired;Role;single-cell RNA sequencing;Smooth Muscle Myocytes;Sodium;Sorting;Source;Streptozocin;Subgroup;Sucrose;symporter;Testing;Toxic effect;transcriptomics;Triglyceride Metabolism;Triglycerides;type I and type II diabetes;Vascular Diseases

PROJECT_TITLE: Project 3: Lipolysis regulation and diabetes-impaired regression


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Therapeutic irradiation is commonly used to treat both primary and metastatic brain tumors and can cause a number of late effects including progressive cognitive dysfunction. There is no treatment currently available that can even partially reverse cognitive changes observed after radiation injury and our data demonstrates. Our proposed studies will identify immune related factors as potentially critical contributors to the susceptibility of the radiation-induced loss of cognitive function.

PI_NAMEs: GUPTA, NALIN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Adolescent;Affect;Age;age effect;Animal Model;Animals;ATAC-seq;Biological;Biological Assay;Brain;brain irradiation injury;Brain Neoplasms;Cellular Structures;Central Nervous System;Central Nervous System Neoplasms;Clinical;clinically relevant;cognitive change;Cognitive deficits;cognitive function;conventional therapy;Cranial Irradiation;CSF1R gene;Data;Dendritic Spines;Development;Euchromatin;Evolution;experimental study;Female;Functional disorder;Gender;Gene Expression;genome-wide;Glioma;Goals;Hippocampus;Immune;Immune system;Immunocompetent;Impaired cognition;in vivo;Individual;Inflammation;Inflammatory Response;inhibitor;Innate Immune System;ionization;Ionizing radiation;irradiation;Late Effects;Learning;Link;Macrophage;male;Measures;Mediating;Memory;Memory impairment;Microglia;model design;Modeling;Modification;monocyte;Mus;Myeloid Cells;Nature;neural;Neurobiology;neuroinflammation;Neurons;Patients;Peripheral;Phenotype;phenotypic biomarker;Population;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Process;Proto-Oncogene Protein c-kit;Publishing;Radiation;radiation during childhood;Radiation Injuries;radiation-induced cognitive dysfunction;recruit;Rodent;Role;sex;Signal Transduction;single-cell RNA sequencing;Synapses;synaptic function;Synaptic Transmission;Synaptosomes;Temporal Lobe;Therapeutic;Time;transcriptome;transcriptomics;tumor;Tyrosine Kinase Inhibitor;young adult

PROJECT_TITLE: Myeloid cells and radiation-induced memory deficits in rodent glioma model: sex and age effects

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Diabetes;Heart Disease;Prevention

PI_NAMEs: HEINECKE, JAY W (contact)

PROJECT_TERMS: Acceleration;analytical method;Animals;Apolipoprotein A-I;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;base;Biological Assay;Biological Markers;Calibration;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cholesterol;Clinical Research;Cohort Studies;Collaborations;Complement;Couples;Data;Defect;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;disorder risk;Event;Exhibits;experience;experimental study;Future;Generations;Genetic Engineering;Genetic Polymorphism;glycemic control;Goals;Heart Diseases;Hepatic;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Hypertriglyceridemia;Impairment;In Vitro;Incidence;interest;ion mobility;Lipids;Lipolysis;Lipoprotein (a);Lipoproteins;Low-Density Lipoproteins;Macrophage;Mediator;Mendelian randomization;Metabolism;Modeling;mouse model;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;particle;Pathway interactions;Patients;Persons;Phospholipid Transfer Proteins;Play;Population;Production;programs;prospective;Proteins;Regulation;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Severities;Testing;Triglycerides;Type 2 diabetic;type I diabetic;Very low density lipoprotein

PROJECT_TITLE: Project 4: Lipoproteins and CVD risk in diabetes


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Mental Health;Neurosciences;Pediatric;Rare Diseases

PHR: Project narrative This proposal expands upon extensive preliminary data to achieve a comprehensive assessment of brain somatic mosaicism, in healthy and diseased brain. This genetic variation may play a role in normal development and may shape individual susceptibility and resilience to neuropsychiatric disorders. We will provide the first comprehensive estimate of the number and frequency of genomic variation in cells of the human brain and will test hypotheses about mechanisms responsible for their creation as well as their significance for brain development.

PI_NAMEs: GLEESON, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Adult;Algorithms;Alleles;Anatomy;Animal Model;Astrocytes;Autopsy;Bar Codes;Behavior;Blood;Brain;brain cell;brain circuitry;Brain Diseases;brain surgery;Cadaver;Candidate Disease Gene;Cell division;Cell Lineage;Cell Size;cell type;Cells;Chemicals;Childhood;Clinical;clinically significant;cohort;Complex;Cortical Dysplasia;Data;Databases;daughter cell;deep sequencing;demethylation;Detection;Development;Developmental Process;disability;Disease;DNA;DNA Damage;DNA Methylation;DNA Sequence Alteration;Dysplasia;Electroencephalography;Electroporation;Embryo;Embryonic Development;Evaluation;Excision;Exposure to;FRAP1 gene;Freezing;Frequencies;Functional disorder;Funding;gene function;Genetic;Genetic Variation;genome sequencing;genomic variation;Genomics;Genotype;Goals;Growth;Human;human model;in utero;Individual;interest;Intractable Epilepsy;Investments;Knowledge;Life;loss of function;Maps;Metabolic stress;Methods;Microglia;migration;Minority;Modeling;mosaic variant;Mosaicism;mouse model;mTOR Inhibitor;Mus;mutant;Mutation;neocortical;neural;Neurodevelopmental Disorder;neurogenesis;neuron development;neuronal circuitry;Neurons;neuropathology;neuropsychiatric disorder;neuropsychiatry;novel;Nuclear;Oligodendroglia;Organism;Outcome;Pathogenicity;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Predisposition;Recording of previous events;recruit;Regional Anatomy;repaired;Resected;resilience;response;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;Somatic Cell;Somatic Mutation;Sorting;success;Synapses;synaptic function;Testing;Tissues;Variant;Work

PROJECT_TITLE: Origins of Brain Somatic Mosaicism in Developmental Brain Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Essential tremor is a common neurological disorder that is often disabling, interfering with daily tasks, and forcing early retirement. Many Veterans with tremor also have anxiety and depression. Current therapies are unsatisfactory. Our initial goals are to confirm our findings that cannabidiol suppresses tremor in the harmaline mouse model of essential tremor, and that a specific enzyme inhibitor that raises the brain level of a natural endocannabinoid also suppresses tremor. Our pilot data indicate that these agents work by activating a specific serotonin receptor subtype. We will seek to confirm out pilot findings that drugs that selectively activate these serotonin receptors suppress tremor and, also study how well they are tolerated and whether their effectiveness wears off. This work will facilitate the development of new therapies for disabling tremor in Veterans that are expected to be potent yet well tolerated. Moreover, based on published data, these treatments are expected to be effective for co-morbid depression and anxiety.

PI_NAMEs: HANDFORTH, CHARLES ADRIAN (contact)

PROJECT_TERMS: Adverse effects;Affect;Agonist;AMPA Receptors;anandamide;Anatomy;Animal Model;antagonist;anti-depressive agents;Anxiety;Autoreceptors;Behavior;Brain;Cannabidiol;Cannabinoids;Cannabis;Cells;Cerebellum;Cerebral cortex;Clinical;clinical efficacy;Clinical Trials;CNR1 gene;CNR2 gene;comorbid depression;Complex;Data;Development;disability;Disabling;Dose;drug repurposing;Drug usage;Drug Utilization;Effectiveness;Endocannabinoids;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Epilepsy;Essential Drugs;Essential Tremor;experimental study;FAAH inhibitor;fatty acid amide hydrolase;gamma-Aminobutyric Acid;Gap Junctions;General Population;Goals;Harmaline;Hepatic;Human;human old age (65+);Impairment;Inferior;Intention Tremor;interest;Knock-out;Knockout Mice;Laboratory Research;Mediating;Mental Depression;Modeling;Molecular Target;mouse model;Mus;Nervous System Disorder;Neurons;novel therapeutics;Occupational;Olives - dietary;Pain;Patients;Persons;Pharmaceutical Preparations;Pharmacology;Pilot Projects;postsynaptic;pre-clinical;Prevalence;programs;Publishing;Purkinje Cells;receptor;Receptor Activation;Reporting;research clinical testing;response;Retirement;Role;Serotonin;Serotonin Agonists;serotonin receptor;Serotonin Receptor 5-HT1A;Serotonin Receptor 5-HT2A;social;stem;T-Type Calcium Channels;Testing;Thalamic structure;Therapeutic;Therapeutic Uses;therapy development;Tremor;TRPV1 gene;Vanilloid;vanilloid receptor subtype 1;Veterans;Withdrawal;Work

PROJECT_TITLE: New Therapies for Essential Tremor from Cannabidiols Mechanisms


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: STOOPS, WILLIAM WALTON (contact);WHITEHURST, LAUREN

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Acceleration;Address;Appalachian Region;Area;Biological Assay;Biology;biomedical informatics;Blood flow;career;career development;Characteristics;Clinical;Clinical and Translational Science Awards;clinical center;clinical effect;Clinical Research;Clinical Sciences;cohort;Collaborations;college;Communication;Communities;Competence;Complex;Data Science;Dentistry;design;Development;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;doctoral student;Education;education research;Educational Activities;Educational Status;Elderly;Engineering;Ensure;Equipment and supply inventories;Ethics;experience;Feedback;Fellowship;Foundations;Funding;Future;Goals;graduate student;Growth;Health;health disparity;health equity;Health Sciences;Healthcare;HIV;Human;improved;Incubators;Infrastructure;Institution;instructor;Interdisciplinary Study;interest;Interview;investigator training;Kentucky;Leadership;Learning;Legal patent;life span;Macular degeneration;Medical;Medicine;Mentors;Methods;Minority Access;Mission;Monitor;multidisciplinary;National Research Service Awards;patient oriented;Pharmaceutical Preparations;Pharmacy facility;Policies;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;prenatal;Preparation;Process;Productivity;professional students;professor;programs;Psychology;Public Health;Publications;Publishing;Qualifying;Rare Diseases;Research;Research Methodology;Research Personnel;Research Training;Residencies;Resources;Role;Scholars Program;Science;Scientist;skills;Social Work;Solid;Students;summer research;Talents;Text;theories;Time Management;TNFSF15 gene;Training;Training and Education;Training Programs;Translational Research;translational scientist;Underrepresented Populations;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: NRSA Training Core


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Liver cancer, also known as hepatocellular carcinoma (HCC), is the fastest growing cause of cancer-related deaths among Americans. HCC occurs in people with liver disease, and fatty liver disease related to metabolic dysfunction (e.g., diabetes, obesity), also called MAFLD, has become the most common liver disease in the world. Our research aims address important gaps in our understanding of how to prevent HCC among people with MAFLD by investigating the role of chemoprevention, surveillance, and risk scores in 3 highly synergistic scientific projects that are supported by 2 shared cores for data and samples collection and analysis.

PI_NAMEs: EL-SERAG, HASHEM B (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;Adult;Affect;Alcoholic Liver Diseases;Algorithms;American;Benefits and Risks;Biochemical;Biological;Biological Assay;Biological Markers;biomarker development;Blood specimen;Cancer Etiology;Carcinoma;Cessation of life;Chemoprevention;Chemopreventive Agent;Chronic Hepatitis C;Cirrhosis;Cities;Clinical;cohort;Collaborations;Collection;Communication;comorbidity;comparative;comparative cost effectiveness;comparative effectiveness;cost effectiveness;curative treatments;Data;Data Analyses;Data Collection;data harmonization;data management;Data Set;design;Development;Diabetes Mellitus;DNA;Epidemic;Etiology;fatty liver disease;Foundations;Functional disorder;Future;Genetic;Genetic Markers;Goals;Hepatitis B;Hepatitis C;high risk;high risk population;Incidence;indexing;Individual;individual variation;individualized prevention;Institution;Knowledge;lipidomics;Liver;Liver Cirrhosis;Liver diseases;liver imaging;Malignant neoplasm of liver;Mathematical Model Simulation;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;metabolic-associated fatty liver disease;metabolomics;Metformin;Modeling;Morbidity - disease rate;mortality;novel;novel marker;Obesity;Pathway interactions;Patients;personalized screening;Persons;Pharmaceutical Preparations;Phenotype;Population;Practice Guidelines;Prevalence;prevent;Prevention;Prevention Research;Prevention strategy;Preventive measure;Primary carcinoma of the liver cells;Process;programs;prospective;Prospective cohort;protective factors;Protocols documentation;radiomics;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resources;Retrospective cohort study;Risk;Risk Factors;risk prediction;Risk Reduction;risk stratification;Role;sample collection;Sampling;Series;Serum;Statistical Data Interpretation;Subgroup;surveillance strategy;Texas;Thiazolidinediones;trait;Ultrasonography;United States;United States National Institutes of Health;web-based tool;Work

PROJECT_TITLE: Prevention of Hepatocellular Carcinoma Related to Metabolic Syndrome


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Cost Effectiveness Research;Diabetes;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Obesity;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Liver cancer, also known as hepatocellular carcinoma (HCC), is the fastest growing cause of cancer-related deaths among Americans with liver disease. Fatty liver disease related to metabolic dysfunction (e.g., diabetes, obesity), also called MAFLD, has become the most common liver disease in the world. Our research is significant because it investigates several risk factors and novel biomarkers that can be reliably used to identify subgroups of MAFLD patients with an increased HCC risk, so they can be targeted for prevention and early detection.

PROJECT_TERMS: Address;adipokines;Age;Alcohol abuse;American;Anti-Inflammatory Agents;Biological Assay;biomarker discovery;biomarker selection;blood-based biomarker;Body fat;Body mass index;Calibration;Cancer Etiology;candidate identification;candidate marker;capsule;Cessation of life;Characteristics;Chemoprevention;Chronic;Chronic viral hepatitis;Cirrhosis;Cities;clinical practice;cohort;Collection;comparative cost effectiveness;cost effectiveness;CSPG3 gene;cytokine;Data;Diabetes Mellitus;Diastolic blood pressure;Discrimination;disease phenotype;Early Diagnosis;ethnic minority;Ethnic Origin;Etiology;Event;Fatty acid glycerol esters;fatty liver disease;follow-up;Functional disorder;General Population;Genetic;Genetic Markers;genetic risk factor;Glycosylated hemoglobin A;Goals;Growth;Hepatitis B;Hepatitis C;High Density Lipoprotein Cholesterol;High Prevalence;high risk;Hispanic Populations;Image;imaging biomarker;improved;indexing;Individual;Infrastructure;Insulin;Insulin Resistance;Lesion;Life Style;lipidomics;Lipids;Liver;Liver diseases;liver imaging;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolic syndrome;metabolic-associated fatty liver disease;metabolomics;Methods;Modeling;molecular marker;Nature;Nested Case-Control Study;novel;novel marker;Obesity;Pathway interactions;Patients;Performance;Persons;Physical activity;polygenic risk score;practice setting;Predictive Value;Prevention;Primary carcinoma of the liver cells;programs;progression risk;prospective;Prospective cohort;Prospective, cohort study;quantitative imaging;Race;racial minority;radiomics;recruit;Research;Risk;Risk Factors;risk prediction;risk stratification;Sampling;Serum;sex;Site;Skin;Smoking;Specificity;Subgroup;Survival Rate;synergism;Texas;tool;Triglycerides;Ultrasonography;ultrasound;Validation;Variant;Waist-Hip Ratio

PROJECT_TITLE: HCC Risk Stratification in MAFLD Cirrhosis


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Nutrition;Obesity;Orphan Drug;Patient Safety;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Liver cancer also known as hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related deaths among Americans. Fatty liver disease related to metabolic dysfunction (e.g., diabetes, obesity), also called MAFLD, has become the most common liver disease in the world. Our research aims are significant because they will examine the effects of promising chemopreventive medications like statins and metformin on preventing the occurrence of HCC, and which groups of patients with MAFLD are most likely to benefit.

PI_NAMEs: KANWAL, FASIHA  (contact)

PROJECT_TERMS: Address;Adverse event;adverse event risk;Affect;American;biological adaptation to stress;burden of illness;cancer chemoprevention;Cancer Etiology;cancer risk;carcinogenesis;Cessation of life;Chemoprevention;Chemopreventive Agent;Child;chronic liver disease;Cirrhosis;Clinical;clinical practice;Clinical Trials;cohort;Cohort Studies;comparative;Complement;curative treatments;Data;design;diabetes control;Diabetes Mellitus;Dose;Dyslipidemias;Etiology;Evaluation;experimental study;fatty liver disease;Fibrosis;Functional disorder;General Population;Genes;Genetic;Genetic Determinism;Genetic Markers;Goals;Guidelines;Hepatocarcinogenesis;Heterogeneity;High Prevalence;high risk;high risk population;Hospitals;human old age (65+);Hybrids;Individual;innovation;Knowledge;Laboratories;Link;Lipids;Liver;Liver Cirrhosis;Liver diseases;Machine Learning;Malignant neoplasm of liver;Manuals;Measures;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;metabolic-associated fatty liver disease;Metformin;mortality;Natural Language Processing;neoplasm registry;Non obese;novel;Obesity;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacy facility;Phenotype;Pioglitazone;Population;predicting response;prevent;Prevention;Prevention strategy;Primary carcinoma of the liver cells;programs;Prospective cohort;Recommendation;Registries;Reporting;Research;Research Design;response;Retrospective cohort;Risk;Risk Factors;Risk Reduction;Series;Severities;Severity of illness;stem;Subgroup;Thiazolidinediones;Toxic effect;trait;tumor;United States Department of Veterans Affairs;Work

PROJECT_TITLE: Chemoprevention of HCC related to MAFLD


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hematology;Infant Mortality;Liver Disease;Microbiome;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: Narrative Two of the more serious clinical syndromes that afflict newborn children are severe neonatal hyperbilirubinemia (SNH), which can develop both in preterm and term newborns and lead to severe CNS toxicity, and necrotizing enterocolitis (NEC), which is mainly restricted to preterm newborns. We will argue and present new findings that the development of SNH and the events leading to protection against NEC are regulated through similar mechanisms, leading us to suggest that the onset of SNH, which displays potent antioxidant properties, is not a random event in preterm newborns but may have evolved as a protective event to combat inflammatory diseases. Using novel animal models that express the human UGT1 locus and the UGT1A1 gene and develop SNH during the neonatal period, experiments are outlined to examine the interrelationships in the mechanisms that control the onset of SNH and NEC with the intention of exploiting these findings to identify potential therapeutic targets to treat NEC.

PI_NAMEs: TUKEY, ROBERT H (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Acids;Acute;Affect;Age;Animal Model;Antioxidants;Area;Ataxia;Athetosis;Bilirubin;Biological;Biological Markers;Birth;Breast Feeding;Catabolism;Cell Lineage;Cell Maturation;Central Nervous System;Cerebral Palsy;Cessation of life;Clinical;combat;constitutive expression;Data;Defect;Development;Developmental Delay Disorders;Disease;Dystonia;effective therapy;Enteral;Event;experimental study;Fatality rate;feeding;Food;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Transcription;Goals;gut inflammation;gut microbiota;hearing impairment;Heme;Human;Human Milk;Hyperbilirubinemia;improved;Individual;Inflammatory;Intention;intestinal barrier;intestinal epithelium;Intestines;Kernicterus;Knock-out;Knockout Mice;Laboratories;Link;Lipopolysaccharides;Liver;mammary;Metabolism;microbiota;Modeling;Morbidity - disease rate;mouse model;Movement Disorders;Mucous body substance;Mus;Muscle hypotonia;NCOR1 gene;Necrotizing Enterocolitis;Neonatal;Neonatal Jaundice;neonatal mice;Neonatal Mortality;neonatal period;neonate;Newborn Infant;novel;Nuclear Receptors;nursing mothers;Nutrient;oculomotor;Oligosaccharides;Oxidative Stress Induction;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;premature;preterm newborn;Process;Production;Property;Proteins;Publications;receptor;Regulation;Repression;reproductive;Research;Risk;Role;Serum;Signal Transduction;Source;Symptoms;Syndrome;Technology;Term Birth;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;TLR4 gene;Toxic effect;Transferase;UDP-Glucuronosyltransferase 1A1;UGT1A1 gene;Work

PROJECT_TITLE: Severe neonatal hyperbilirubinemia (SNH) and the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) play key roles in the development of necrotizing enterocolitis (NEC)

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Primary liver cancer also known as Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer- related deaths in the United States. This research aims to fill gaps in our understanding of the pros and cons of two HCC prevention strategies -- surveillance and chemoprevention -- in individuals with metabolic dysfunction (e.g., diabetes, obesity) associated HCC. We propose to develop the first publicly available on-line tool, HCC Simulator, for providers and their patients that will give real-time information (including graphic report print- outs) on the risk of developing HCC and effective prevention plan, all based on individual patient’s risk factors.

PI_NAMEs: CHHATWAL, JAGPREET  (contact)

PROJECT_TERMS: Address;Adult;Affect;Alcoholic Liver Diseases;American;Biological Markers;Cancer Detection;Cancer Etiology;Cardiovascular system;Cessation of life;Chemoprevention;chronic liver disease;Cirrhosis;Clinical;clinical care;cohort;comparative;comparative cost effectiveness;comparative effectiveness;Complement;cost;cost effective;cost effectiveness;Data;Diabetes Mellitus;Ethics;Etiology;fatty liver disease;Frequencies;Functional disorder;Geography;Goals;Guidelines;Hepatitis B;Hepatitis C;Heterogeneity;high risk;Image;Individual;individual patient;innovation;Life Expectancy;lifetime risk;Literature;mathematical model;Metabolic;Metabolic dysfunction;Metabolic syndrome;metabolic-associated fatty liver disease;Metformin;Modality;Modeling;Morbidity - disease rate;mortality;Natural History;novel;novel marker;Obesity;Outcome;Patients;personalized approach;Physicians;Policies;Practice Guidelines;prevent;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;programs;prospective;Provider;Publishing;Randomized, Controlled Trials;Recommendation;Reporting;Research;Retrospective cohort;Risk;Risk Factors;screening;Screening for cancer;screening guidelines;Sensitivity and Specificity;Serum;Severities;Severity of illness;simulation;Site;Source;Subgroup;support tools;surveillance strategy;Testing;Time;tool;trait;trial comparing;ultrasound;United States;United States Preventative Services Task Force;virtual;Work

PROJECT_TITLE: Comparative cost-effectiveness of HCC prevention in metabolic dysfunction associated fatty liver disease


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative The goal of this training program is to prepare individuals of outstanding potential for independent research careers in dental, oral and craniofacial research. Training of these individuals is critical to the health and quality of life of the American public.

PI_NAMEs: MINA, MINA  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Area;behavioral and social science;Bioinformatics;Biology;Biotechnology;Cancer Biology;career development;Clinical;Clinical Research;Collaborations;Computational Biology;craniofacial;Dedications;Dental;Dental Schools;Doctor of Philosophy;embryonic stem cell;Enrollment;Ensure;Environment;Evolution;experience;Faculty;flexibility;Foundations;Funding;Genomic medicine;Government;Grant;Health;Imaging Techniques;Immunology;Individual;Industry;Institution;Interdisciplinary Study;Interview;Laboratories;materials science;mathematical model;Medicine;Mesenchymal Stem Cells;microbiome;Mucous Membrane;next generation;Oral;oral biology;patient oriented research;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Productivity;programs;recruit;Regenerative Medicine;Research;research and development;Research Training;Science;Scientist;skeletal;Social Sciences;Solid;Students;symposium;The Jackson Laboratory;Training;Training Programs;Training Support;Underrepresented Minority

PROJECT_TITLE: Skeletal, Craniofacial and Oral Biology Training Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROGRAM NARRATIVE Health services research indicates those with dementia utilize healthcare differently than controls, and initial studies suggest mild cognitive impairment may also be related to altered patterns of healthcare utilization. Better understanding use of health services in older adults across the spectrum of cognitive impairment is essential to: (i) future resource planning and allocation, (ii) development of cost management strategie s; and (iii) identification of areas where healthcare patterns might eventually be improved, especially in early disease, when changes may be easier to implement. We propose to examine differences in healthcare utilization, in use of dementia drugs, and in end-of-life care, across those with no cognitive impairment, mild cognitive impairment, and dementia, using a unique linkage of Medicare claims data with rigorous cognitive data from several cohorts of cognitive aging.

PI_NAMEs: BYNUM, JULIE PW;GRODSTEIN, FRANCINE  (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Affect;African American;African American population;Age;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavioral;burden of illness;Caring;Categories;Cessation of life;Characteristics;Chronic;Classification;Clinical;Cognition;Cognitive;Cognitive aging;cognitive testing;cohort;comorbidity;cost;Data;Dementia;Development;Diagnosis;Disease;Drug Prescriptions;Eligibility Determination;Emergency department visit;end of life care;Epidemiology;Evaluation;Expenditure;Fee-for-Service Plans;follow-up;Functional impairment;Future;Geriatrics;Grant;Health;health care service utilization;health difference;health management;health service use;Health Services;Health Services Research;Healthcare;high risk;hospice environment;Hospitalization;Hospitals;Impaired cognition;improved;Individual;inpatient service;Intervention;Investigation;Link;Measures;Medicare;Medicare claim;mild cognitive impairment;minority health;Modification;Neurologic;Neurology;Neuropsychology;novel;older adult;Older Population;outpatient programs;Participant;Pattern;Patterns of Care;Pharmaceutical Preparations;Population;prospective;Race;Research;Resources;Sampling;Services;Severities;sex;social;Statistical Methods;Surveys;Time;Translations;Visit;Work

PROJECT_TITLE: Use of Healthcare Across the Full Continuum of Cognitive Health and Decline in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-L(90)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Nutrition;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The Program Project includes investigators from several institutions conducting three research projects, and supported by two shared resources cores to better understand and reduce the risk of developing the most common type of liver cancer, hepatocellular carcinoma (HCC), among individuals with metabolic dysfunction (e.g., diabetes, obesity). The Administrative Core will provide the overall administration (including financial and operational management), governance, communication, coordination and support for the Program Project. The Administrative Core has a Director, Associate Director, Executive Committee and an External Advisory Committee.

PROJECT_TERMS: Administrator;Advisory Committees;anti-cancer research;Award;Biochemical Markers;biomarker development;Cancer Biology;Cancer Center;cancer prevention;Center for Translational Science Activities;Chemoprevention;college;Communication;Computer software;conflict resolution;dashboard;Data;Dedications;Department chair;Diabetes Mellitus;Electronics;Ensure;Epidemiology;experience;fatty liver disease;Focus Groups;Functional disorder;Funding;Gastroenterology;General Hospitals;Genetic Markers;Goals;Hepatology;Hospitals;Human Resources;Individual;Information Dissemination;Infrastructure;Institution;Leadership;Liver diseases;Malignant neoplasm of liver;Massachusetts;medical schools;Medicine;meetings;Metabolic;Metabolic dysfunction;Metabolic syndrome;Methods;Mission;Monitor;mortality;multidisciplinary;Obesity;Occupational activity of managing finances;Online Systems;operation;Pennsylvania;Performance;phenotypic biomarker;Policies;Prevention;Prevention strategy;Primary carcinoma of the liver cells;process optimization;professor;Program Evaluation;programs;Protocols documentation;Qualifying;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Risk Reduction;Running;Science;Services;Structure;success;symposium;synergism;System;Technology;Texas;Time;timeline;United States National Institutes of Health;Universities;web based software;web site;webinar;Woman

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research

ORG_DEPT: NEUROLOGY

PHR: Vestibular migraine (VM) is among the leading causes of dizziness and spatial disorientation with an unknown pathophysiology. Here we apply a rigorous framework to (i) determine sensory contributions to spatial disorientation in VM patients, (ii) find the link between these measures and clinical sign and symptoms in VM patients, and 3) examine the role of neural networks that contribute to spatial disori- entation in VM pathophysiology. These are crucial steps towards devising effective treatment strategies for the debilitating symptoms in VM patients.

PI_NAMEs: KHERADMAND, AMIR  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;analog;Bayesian Modeling;Biological Markers;body position;Brain;Brain Stem;Clinical;Control Groups;Data;debilitating symptom;Dependence;Development;Diagnosis;disabling symptom;Disorientation;Dizziness;effective therapy;Environment;Exhibits;Eye;Functional disorder;General Population;Head;indexing;insight;Link;Measures;Mediating;Methods;Migraine;Modeling;multisensory;neural correlate;neural network;neuromechanism;neurophysiology;novel;Optokinetic nystagmus;Pathologic Nystagmus;Patients;Peripheral;Positioning Attribute;Posture;posture instability;Prevalence;Psychophysics;Recovery;Research;Role;Sensory;sensory integration;sensory mechanism;Sensory Process;Severities;Signal Transduction;Signs and Symptoms;Source;Space Perception;spatial integration;Symptoms;Techniques;Testing;transcranial direct current stimulation;Transcranial magnetic stimulation;treatment effect;treatment strategy;Vertigo;Vestibular dysfunction;Vestibular function;vestibular system;Visual;Visual Motion;visual stimulus;visual tracking;Visuospatial;Work

PROJECT_TITLE: Elucidating the neural mechanisms of spatial disorientation in vestibular migraine