NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Patient Safety

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOPHYSICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Fluoride, the main agent for dental caries control, has limited antimicrobial effect because most microbes express membrane proteins to expel fluoride and keep cytoplasmic concentrations low. The goal of this project is to determine how inhibition of fluoride exporters from cariogenic species Streptococcus mutans and Candida albicans alters the microbial composition of dental biofilms, and identify natural products that could cause fluoride export inhibition. The ultimate goal is to potentiate the anticaries effect of fluoride in over-the-counter products like toothpastes and mouth rinses.

PI_NAMEs: ANDALO-TENUTA, LIVIA MARIA;STOCKBRIDGE, RANDY B. (contact)

PROJECT_TERMS: Adult;Affect;Age;anticaries;antimicrobial;Antimicrobial Effect;Bacteria;Biochemical;Biodiversity;biofilm species;Biological Assay;Biosensor;Candida albicans;Chemicals;Chemosensitization;Child;Chlorhexidine;Communities;Consumption;Crude Extracts;Culture Media;Cytoplasm;Data;dental agent;dental biofilm;Dental caries;Development;Diet;Dietary Sugars;Disease;dysbiosis;Ecology;economic impact;Electrophysiology (science);experimental study;Exposure to;Family;fitness;Fluoride Ion;Fluorides;fungus;Gene Cluster;Genetic;genetic profiling;Goals;Growth;Health;high throughput screening;Hypersensitivity;Impairment;improved;Individual;Informatics;Knock-out;Knowledge;Lesion;Libraries;Membrane Proteins;Metabolic;Metabolism;Microbe;microbial;Microbial Biofilms;microbial composition;Minerals;Modernization;Monitor;Morbidity - disease rate;mortality;Natural Products;novel;novel therapeutics;nutrition;older adult;Oral;oral bacteria;oral biofilm;Oral cavity;Oral health;oral microbial community;oral pathogen;oral streptococci;Output;Pain;Pathogenicity;Patients;Periodicals;Persons;physiologic model;Physiological;polymicrobial biofilm;prevent;Process;Productivity;Protein Export Pathway;Proteins;Quality of life;resistance mechanism;Risk;RNA;Role;Schools;side effect;Social Functioning;Sorting;Specificity;Streptococcus gordonii;Streptococcus mutans;sugar;Testing;Toothpaste;Toxic effect;Variant;Vulnerable Populations;Work;Yeasts

PROJECT_TITLE: Potentiation of fluoride toxicity in oral pathogens


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Sepsis causes more than 250,000 deaths each year in the United States. However, there are no effective therapeutics. This proposal will investigate the physiological function of a mammalian gene in sepsis pathogenesis using a transgenic mouse model and could provide a new therapeutic target.

PI_NAMEs: WANG, PENGHUA  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Age;Apoptosis;ATP phosphohydrolase;Binding;Carcinoma;CASP1 gene;Caspase;cecal ligation puncture;Cell Cycle;Cell Death;Cell membrane;Cells;Cellular Stress;Cervical;Cessation of life;effective therapy;Embryo;Endoplasmic Reticulum;Endotoxemia;Endotoxins;Foundations;Future;Genes;Hela Cells;Histopathology;Human;Human body;Human Characteristics;Human Genome;Hyperactivity;IL18 gene;Immune response;Impairment;in vivo;Infection;Inflammasome;Inflammation Mediators;Inflammatory;Inflammatory Response;Interferon Type II;Interleukin-1;Kinetics;Knock-out;Knockout Mice;Learning;Life;Link;Lipopolysaccharides;Macrophage;Mediating;Methods;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;new therapeutic target;novel therapeutic intervention;Pathogenesis;Pathology;Pathway interactions;Pattern recognition receptor;Physiological;Plasma Cells;Play;polymicrobial sepsis;pre-clinical;Process;Production;protein degradation;Proteins;Receptor Signaling;recruit;Research;Resistance;response;Rodent;Role;Sepsis;sex;Signal Transduction;Solid;Testing;therapeutic target;therapeutically effective;TLR4 gene;tool;trafficking;Transfection;Transgenic Mice;Ubiquitin;ubiquitin-protein ligase;United States

PROJECT_TITLE: UBXN1 Regulates Inflammasome Signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative: Human long-lived plasma cells (LLPC) reside in the bone marrow (BM) and are responsible for the long-term maintenance of serum antibody levels after vaccination. This application will understand the molecular mechanisms responsible for the generation and survival of LLPC in order to understand how to generate life- long protective immunity which has tremendous importance in vaccine biology.

PI_NAMEs: LEE, FRANCES EUN-HYUNG (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adult;Affect;angiogenesis;Antibodies;Antigens;Atlases;autocrine;Binding;Biological Assay;Biology;Blood;Bone Marrow;Cell Maintenance;Cell Maturation;Cell Survival;cell transformation;Cells;Cellular Morphology;cellular resilience;Chronology;cytokine;Development;differentiation in vitro;Epigenetic Process;Excision;Generations;Genetic Transcription;Genus Mentha;Glycolysis;Growth Factor;heparin proteoglycan;herpesvirus entry mediator;Heterogeneity;high voltage electron microscopy;Human;Human Resources;Immunity;Immunoglobulin-Secreting Cells;Immunoglobulins;In Vitro;in vitro testing;inhibiting antibody;inhibitor;Lightning;Link;lymph nodes;Maintenance;Malignant Neoplasms;MCL1 gene;member;midkine;migration;Molecular;novel;OX40;Pathogenicity;Phenotype;plasma cell development;Plasma Cells;Plasmablast;Play;prevent;programs;Proliferating;promote resilience;Property;Proteomics;receptor;Recovery;resilience;Role;secretory protein;Serum;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;SNAP receptor;Stress;Surface;T-Cell Activation;Testing;Time;TNF gene;TNFRSF17 gene;transcriptome;Tumor Necrosis Factor Receptor;Vaccination;Vaccine Design;vaccine response;Vaccines

PROJECT_TITLE: Human Plasma Cell Maturation & Maintenance through CD138, TNFRSF, and Modulation of Ig Secretion

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Some people with aphasia can express themselves more fluently by singing rather than speaking. This project will explore this behavior in depth to understand the conditions in which song is easier to produce than speech. At the same time, the brain mechanisms that support speech and song will be studied with state-of-the-art brain imaging and neurophysiological tools in two patient populations.

PI_NAMEs: DRONKERS, NINA F. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TITLE: Neural Mechanisms of Song vs Speech Production: Insights from Aphasia and Intracranial Recording

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prevention;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Mindfulness and acupuncture are non-pharmacologic interventions that can effectively address postsurgical pain and reliance on opioids, however the size of their effects is small. Given their distinct yet complementary therapeutic targets, integrating mindfulness and acupuncture into a combined program has strong potential for additive or even synergistic effects that could substantially reduce risk for persistent pain and opioid use following surgery. The purpose of the proposed R34 project is to assess the feasibility and acceptability of an integrated program that combines mindfulness delivered via mobile app (mHealth) with auricular acupuncture in individuals undergoing spine surgery (I-MASS) in preparation for a fully powered, pragmatic, randomized comparative effectiveness trial.

PI_NAMEs: GOERTZ, CHRISTINE MARIE;LENTZ, TREVOR  (contact)

PROGRAM_OFFICER_NAME: GINEXI, ELIZABETH M

PROJECT_TERMS: academic standard;acceptability and feasibility;Accounting;Acupuncture Therapy;addiction;Address;Administrator;Adult;Age;Analgesics;Anxiety;Area;arm;Back;Behavioral;burden of illness;care delivery;Caring;Clinical;clinical efficacy;Clinical Practice Guideline;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;comparative effectiveness;comparative effectiveness trial;compare effectiveness;cost;cost effective;Data;Data Collection;design;Development;Ear Acupuncture;Effectiveness;effectiveness study;efficacy study;Electronic Health Record;epidemiologic data;experience;feasibility testing;feasibility trial;global health;Goals;Guidelines;Health Personnel;Health system;Health Technology;Healthcare;Image;improved;improved outcome;Incidence;Individual;innovation;Integrative Therapy;Intervention;Interview;Knowledge;Laminectomy;Lifting;Medical;Mental Depression;Methods;mHealth;mind/body;mindfulness;Mindfulness Training;mobile application;multi-component intervention;multimodality;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Opioid;opioid misuse;opioid overdose;opioid use;Outcome;Overdose;Pain;Pain management;pain reduction;pain relief;pain sensitivity;participant retention;Pathway interactions;Patient Education;Patients;Persistent pain;Persons;Physical therapy;Postoperative Pain;pragmatic trial;preference;Preparation;Procedures;programs;protocol development;Protocols documentation;psychologic;Psychological Factors;Questionnaires;Randomized;Randomized Controlled Clinical Trials;randomized trial;Recommendation;recruit;Reporting;Research;Research Priority;Research Proposals;Resources;retention rate;Risk;Risk Factors;Risk Reduction;satisfaction;Site;Spine pain;Spine surgery;Structure;Surgeon;Testing;Therapeutic;therapeutic target;treatment as usual;trial comparing;United States;United States National Institutes of Health;usability;Vertebral column;Visit;Work

PROJECT_TITLE: Feasibility Trial of a Novel Integrated Mindfulness and Acupuncture Program to Improve Outcomes after Spine Surgery (I-MASS)


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Tumor-derived exosomes have shown the promise to elicit humoral and cytotoxic T lymphocyte (CTL) response in preclinical studies and clinical trials, but the antitumor efficacy is still very limited. The primary goal of this project is to develop a generalizable technology for generating chemically tagged exosomes from tumor cells and further develop adjuvant-conjugated exosomes with enhanced CTL response and antitumor efficacy.

PI_NAMEs: WANG, HUA  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Adjuvant;Agonist;Antigen Presentation;Antigen-Presenting Cells;Antigens;Azides;Binding;cancer cell;cancer therapy;cancer type;Cancer Vaccines;Cell membrane;Chemicals;Chemistry;Clinical;clinical translation;Clinical Trials;Cytotoxic T-Lymphocytes;Dendritic cell activation;Dendritic Cells;Development;efficacy evaluation;Endosomes;exosome;extracellular vesicles;Generations;Glioblastoma;Glycoengineering;Glycolipids;Glycoproteins;Goals;immune modulating agents;Immunomodulators;Immunotherapy;improved;Inherited;Label;Ligands;Malignant Breast Neoplasm;Mediating;Membrane;Membrane Glycoproteins;Metabolic;Modeling;Mus;nanosized;neoplastic cell;Polysaccharides;pre-clinical;preclinical study;Process;Proteins;response;Safety;Source;success;sugar;Surface;Technology;Testing;Therapeutic;TLR3 gene;TLR7 gene;TLR8 gene;Toll-like receptors;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor-Derived;uptake;Vaccination;Vaccines

PROJECT_TITLE: Metabolic tagging of tumor exosomes for developing enhanced exosome vaccines


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative One of the most important unanswered questions in neuroscience is how the brain learns to recognize, represent, and predict temporal relationships. This project will address this issue by using the early visual system to determine how cortical circuits encode and predict spatiotemporal visual information. Understanding the mechanisms supporting this ability will provide deeper insight into brain function and into various neurological and psychiatric disorders that disrupt the ability to accurately process temporal information.

PI_NAMEs: GAVORNIK, JEFFREY PETER (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Animal Model;antagonist;area striata;basal forebrain;Behavior;Behavioral Assay;Brain;Categories;Chemosensitization;cholinergic;cholinergic neuron;Code;Cognition;cognitive function;Dissection;Electrophysiology (science);Elements;Event;experience;experimental study;Feedback;Functional Imaging;Goals;Hour;human model;Image;Influentials;Information Storage;insight;Interneurons;Learning;Long-Term Potentiation;Mediating;Memory;memory recall;Mental disorders;Modeling;Modernization;Modification;motor control;Mus;Muscarinic Acetylcholine Receptor;Muscarinics;Neocortex;Nervous System Disorder;neural network;Neurobiology;neuromechanism;Neurosciences;Ocular Physiology;Pattern;Perception;Photic Stimulation;Physiological;Physiology;Play;predictive modeling;Probability;Process;Protocols documentation;Rapid screening;Receptor Signaling;response;Role;Sensory;sensory cortex;Signal Pathway;Signal Transduction;spatiotemporal;Stimulus;Structure;System;Testing;Time;tool;Training;Transition Elements;Visual;visual information;visual stimulus;Visual System;Work

PROJECT_TITLE: A mechanistic dissection of short and long term spatiotemporal learning in V1

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: NARRATIVE Chronic pain is a major public health problem and treatments frequently require opioids resulting in a major epidemic of abuse in the United States. New, non-addicting treatments for pain are critically needed, and ultrasound presents a non-surgical, non-invasive method to modulate brain activity involved in pain. This project will examine how ultrasound modulates pain processing mechanisms in the human brain, and will produce information that will help to advance ultrasound as a method to enhance the health and reduce suffering in those with chronic pain.

PI_NAMEs: LEGON, WYNN  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acute;addiction;Affect;allodynia;American;Anterior;autism spectrum disorder;Behavior;behavior measurement;Brain;Central Nervous System;central pain;central sensitization;Cephalic;Characteristics;chronic pain;chronic pain management;Chronic pain syndrome;chronic painful condition;Clinical;conditioned pain modulation;cost;cranium;Data;Economics;effective therapy;Effectiveness;effectiveness testing;Electric Stimulation;Epidemic;Evoked Potentials;experience;Feeling;Fibromyalgia;fibromyalgia patients;Focused Ultrasound;Functional disorder;Goals;Health;Human;Human Volunteers;Hyperalgesia;Individual;Insula of Reil;Lasers;Link;Measures;Mental Depression;Methods;millimeter;neuroregulation;Neurosurgical Procedures;noninvasive brain stimulation;Nonpharmacologic Therapy;novel;Opioid;Pain;Pain management;pain processing;Penetration;Pharmacological Treatment;Public Health;Reporting;Resolution;response;Role;Safety;Sensory;sensory gating;sensory input;sensory system;social;Source;Spottings;stem;Stimulus;Surface;Techniques;Testing;tool;Transcranial magnetic stimulation;Translations;ultrasound;United States

PROJECT_TITLE: High resolution interrogation of the insula in mechanisms of chronic pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia is the most common complication of premature birth whose incidence is on the rise resulting in long term adverse multiorgan complications. Our research has shown that mesenchymal stromal cell extracellular vesicles (MEx) have profound protective effects on experimental models of BPD by reprogramming the body’s immune cells to resolve injury and promote normal lung development. Using a multifaceted approach, we plan to investigate the molecular and cellular pathways by which MEx reprogram immune cells in the neonatal period and how these changes affect long term immune function and susceptibility to disease later in life.

PI_NAMEs: KOUREMBANAS, STELLA  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: adaptive immunity;Adoptive Transfer;Adult;Affect;Airway Disease;airway hyperresponsiveness;airway inflammation;Alveolar;Alveolar Macrophages;Anti-Inflammatory Agents;Apoptotic;Architecture;Asthma;Biological;Bone Marrow;Brain;Bronchopulmonary Dysplasia;Cell Physiology;Cell Therapy;Cells;Clinical Trials;Complex;Complication;cytokine;Development;Disease;effective therapy;Etiology;exercise capacity;exosome;Experimental Models;experimental study;extracellular vesicles;extreme prematurity;Fibrosis;functional outcomes;Gene Modified;Goals;Growth;Histologic;Human;Hyperoxia;hyperoxia induced lung injury;Immune;immune function;Immunity;immunoreactivity;improved;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;Injury;injury and repair;intraamniotic infection;Life;Lung;lung development;Macrophage;Mechanical ventilation;Mediating;Mesenchymal;mesenchymal stromal cell;Modality;Modeling;Molecular;monocyte;Morbidity - disease rate;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Neonatal Hyperoxic Injury;neonatal lung disease;neonatal period;Neurological outcome;Organ;organ injury;Oxygen;Pathogenesis;Pathway interactions;Perinatal;Phenotype;Population;Pre-Eclampsia;Predisposition;premature;Premature Birth;prenatal risk factor;Prevention strategy;programs;protective effect;Pulmonary Emphysema;Pulmonary Inflammation;recruit;Research;Retina;Role;Signal Pathway;Signal Transduction;stem;Stromal Cells;Structure of thymic medulla;System;systemic inflammatory response;T-Cell Development;Testing;Therapeutic;Thymus Gland;Tissues;translational approach;Vascular remodeling;vector

PROJECT_TITLE: MSC Exosome Treatment for BPD: Impact on Immunity and Lung Development

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Alzheimer's disease (AD) is a chronic illness whose ultimate clinical expression as dementia follows years if not decades of injury, response to injury, consumption of reserve, and compensation. Genetic risk for AD now clearly highlights the potential for multiple molecular drivers and perhaps multiple pathogenic pathways. To monitor AD progression or response to treatment, cerebrospinal fluid (CSF) represents the preferred fluid to reflect brain pathophysiology. We propose to enable precision medicine for AD by developing a cooperative research program that will unite a unique research team with the specific goal of vastly improving the molecular characterization of CSF as predictors of cognitive decline and AD pathophysiology.

PI_NAMEs: MACCOSS, MICHAEL  (contact);MONTINE, THOMAS J

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Adoption;Affinity;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid deposition;Biological Assay;Biological Markers;Blood - brain barrier anatomy;Blood Proteins;Brain;Brain Mapping;Brain region;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Chronic Disease;Clinical;clinical diagnostics;clinically relevant;Compensation;Complement;Consensus;Consumption;Custom;Data;data dissemination;data sharing;Dementia;Detection;Development;Diagnosis;Diagnostic tests;diagnostic value;Disease;Disease Progression;extracellular vesicles;Flow Cytometry;Functional disorder;Genetic Risk;Goals;Human;Impaired cognition;improved;in vivo;Individual;Infrastructure;Injury;innovation;Intercellular Fluid;Lipoproteins;Liquid substance;Logic;Mass Spectrum Analysis;Medicine;Methods;Mission;Molecular;molecular imaging;Molecular Profiling;Monitor;Multiplexed Ion Beam Imaging;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuronal Injury;Neuropsychological Tests;Neurosciences;new technology;next generation;novel;outcome prediction;particle;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral;precision medicine;Process;programs;protein biomarkers;Protein Engineering;Proteins;Proteomics;Protocols documentation;Public Health;Reagent;Reproducibility;Research;Research Personnel;Resources;response to injury;Sampling;Specimen;System;Technology;therapeutic target;translational applications;translational proteomics;Transportation;treatment response;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Next Generation Translational Proteomics for Alzheimer's and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MACCOSS, MICHAEL  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;arm;Brain;Collaborations;Communities;Development;Disease Progression;Ensure;experience;Fostering;Free Will;Functional disorder;Individual;Infrastructure;Learning;Monitor;new technology;next generation;Positioning Attribute;Privatization;Productivity;programs;Protocols documentation;Reagent;Reporting;Research;Research Personnel;Resources;Series;Technology;Time;translational impact;translational proteomics;treatment response;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Core 1: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: POSTON, KATHLEEN LOMBARD (contact)

PROJECT_TERMS: Abbreviations;Alzheimer's Disease;Alzheimer's disease related dementia;Archives;Autopsy;Award;Brain;Cerebrospinal Fluid;Cerebrovascular Trauma;Clinical;clinical diagnosis;clinical diagnostics;Clinical Research;Consensus;Data;Dementia with Lewy Bodies;Diagnostic;Diagnostic tests;Disasters;Enrollment;Evaluation;extracellular vesicles;Health;Individual;Lewy Body Disease;Lipoproteins;Nervous System Disorder;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;next generation;Older Population;Parkinson Disease;Parkinson's Dementia;Participant;programs;Proteins;Public Health;Research;Research Infrastructure;Research Institute;Resource Allocation;Resources;Review Committee;Sampling;Source;Spinal Puncture;Test Result;Therapeutic;Time;translational proteomics;Ventricular;Work

PROJECT_TITLE: Core 2: Clinical Resource Core


PI_NAMEs: HOOFNAGLE, ANDREW N (contact)

PROJECT_TERMS: Affinity;Alzheimer's Disease;Alzheimer's disease related dementia;Antibodies;Applications Grants;assay development;Autoantibodies;Binding;Biological Assay;Biological Markers;Body Fluids;Brain imaging;Cell Separation;Cerebrospinal Fluid;Clinical;Column Chromatography;Complex Mixtures;data dissemination;Deposition;design;Digestion;direct patient care;Elements;Ensure;experimental study;extracellular vesicles;Family;Goals;Human;human disease;Hybridomas;Image;imaging study;Immunoassay;improved;instrument;interest;Investigation;Iowa;Label;Laboratories;Lipoproteins;Liquid Chromatography;mass spectrometer;Modernization;molecular mass;Monoclonal Antibodies;Mus;Natural regeneration;next generation;North America;novel;Oryctolagus cuniculus;particle;Patients;Peptides;Plasma;Proteins;Proteolysis;Reagent;Reproducibility;Research;Research Personnel;Running;Sampling;Serum;Specificity;tandem mass spectrometry;Techniques;Technology;Thyroglobulin;Time;Tissues;tool;translational proteomics;Trypsin;Universities;Washington

PROJECT_TITLE: Core 3: The Affinity Reagent Characterization Core


NIH_SPENDING_CATS: Cancer;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative  Dysregulation of DNA damage and repair is an important hallmark of prostate cancer that is associated with increased risk of disease aggressiveness and failed response to treatment. Our studies will provide a comprehensive assessment of the functions of two key DNA repair genes, namely BRCA1 and BRCA2, in prostate cancer progression, metastasis, and treatment, as well as the foundation for broader analyses of DNA damage and DNA repair in prostate tumorigenesis. Overall, we envision that these studies will refine the management and treatment of men with lethal prostate cancer.

PI_NAMEs: ABATE-SHEN, CORY  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;advanced prostate cancer;Allografting;Androgens;Anti-androgen Therapy;Biochemical;Biological;Biological Assay;Biological Process;bone;BRCA1 gene;BRCA2 gene;Cancer Etiology;cancer therapy;candidate identification;Castration;Cells;Cessation of life;chemotherapy;clinical investigation;clinical practice;Clinical Trials;clinically relevant;Complement;computerized tools;deprivation;Development;Disease;Disease Progression;disorder risk;DNA analysis;DNA Damage;DNA Repair;DNA Repair Gene;Double Strand Break Repair;Drug Combinations;Drug Targeting;Foundations;Funding;Future;gene function;Generations;Genes;Genetically Engineered Mouse;genome integrity;genome-wide;Human;Individual;individual patient;innovation;insight;loss of function;Malignant neoplasm of prostate;men;Metastatic Prostate Cancer;Modeling;Molecular;Mus;Neoplasm Metastasis;new therapeutic target;Organoids;Patients;Pharmaceutical Preparations;Phenotype;Play;pre-clinical;precision oncology;Primary Neoplasm;Prostate;prostate cancer progression;prostate carcinogenesis;Prostatic Neoplasms;repair function;Resistance;Resources;response;Role;Series;single nucleus RNA-sequencing;targeted agent;Treatment Failure;treatment response;tumor;Tumor Suppressor Genes;Variant

PROJECT_TITLE: Preclinical analyses of advanced prostate cancer in genetically-engineered mice

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: TIAN, LU  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Big Data;Bioinformatics;Biometry;Consultations;Data;Data Analyses;data dissemination;data management;Data Management Resources;Data Set;data sharing;Education;experience;innovation;Laboratory Scientists;Manuscripts;next generation;Paper;Postdoctoral Fellow;programs;Research;research data dissemination;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Statistical Data Interpretation;success;tool;translational proteomics;Writing

PROJECT_TITLE: Core 4: Statistical Analysis and Data Dissemination


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE  It is unclear whether and to what extent cannabis use impacts early parenting behaviors and the maternal- infant relationship, whether these effects are confounded by critical social environmental factors, and what role stress coping may play in the relationship. The proposed project will seek to answer these questions and in doing so will promote the development of tailored interventions to reduce inequities in drug-related consequences across the life course by supporting parents co-managing stress, substance use and parenting with the objective of reducing the intergenerational transmission of cannabis harm. The importance of understanding these relationships is underscored by shifting social norms and policies surrounding adult cannabis use in the United States, adding further urgency to the task of identifying biological, environmental, behavioral and social causes and consequences of cannabis use and addiction across the lifespan.

PI_NAMEs: SOKOL, NATASHA ALESSANDRA (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acute;Address;Adult;antenatal;Area;Award;Behavior;behavior observation;Behavioral;Biological;Biological Assay;Biological Markers;Cannabis;cannabis administration;Cannabis policy;cannabis use behavior;career;career development;Child;Child Health;Child Rearing;Chronic stress;Clinical Research;Cognitive;Complex;coping mechanism;critical period;Data Analyses;Data Collection;design;Development;Developmental Process;developmental psychology;Discrimination;Disparity;Drug Addiction;drug of abuse;Drug usage;Education;Emotional;Environment;Environmental Risk Factor;Epidemiologic Methods;epidemiological model;experience;Family;Frequencies;Goals;Growth;Harm Reduction;Health;Health behavior;health disparity;health inequalities;Hormones;Human Subject Research;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;Income;Individual;Inequity;Infant;insight;intergenerational;Intervention;Interview;Laboratories;Legal;Life course epidemiology;Life Cycle Stages;life span;Longitudinal cohort;Marijuana Dependence;marijuana use;marijuana user;Maternal and Child Health;maternal marijuana use;Measurement;Measures;Mediating;Mental Health;Mentored Research Scientist Development Award;Methods;Mothers;Motivation;National Institute of Drug Abuse;novel;offspring;Outcome;outcome disparities;parenting intervention;Parents;Pathway interactions;peer;perceived stress;Pharmaceutical Preparations;physical conditioning;Physiological;Play;Population;postnatal;Postpartum Period;Pregnancy;Pregnant Women;Prevalence;prospective;Qualitative Methods;Race;Reporting;Research;Research Personnel;Risk;Role;social;social determinants;Social Environment;social epidemiology;social norm;Social Policies;Societies;socioeconomics;Statistical Methods;Strategic Planning;Stress;Stress and Coping;stress management;substance use;Surveys;Techniques;Theoretical model;therapy development;Training;Training Activity;transmission process;United States;Women's cohort

PROJECT_TITLE: The Effect of Antenatal Maternal Cannabis Use on Parenting Behavior

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


PROJECT_TERMS: Adopted;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid Fibrils;Apolipoprotein E;Biological Assay;Biological Markers;Brain;brain cell;candidate marker;Categories;Cells;Cholesterol Homeostasis;Clinical;clinical diagnosis;clinical practice;cohort;comorbidity;Data;Detection;Development;Differential Diagnosis;Digestion;Disease;Enzyme-Linked Immunosorbent Assay;exosome;Extracellular Fluid;extracellular vesicles;Failure;falls;Functional disorder;Human;Hybrids;improved;Individual;inhibitor;Interneurons;Lipoproteins;Mass Spectrum Analysis;Measures;Methods;misfolded protein;Modification;Molecular Conformation;Molecular Weight;Monitor;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;neuroinflammation;next generation;particle;Pathogenesis;Pathogenicity;Pathology;Peptide Hydrolases;Peptides;Performance;Predisposition;Process;programs;protein folding;Protein Isoforms;protein misfolding;Protein Truncation;Proteins;Proteome;Proteomics;Reaction;recruit;Reproducibility;Research;RNA Splicing;Role;Sampling;Source;sulfated glycoprotein 2;Symptoms;tau Proteins;tau-1;Technology;Temperature;thermal stress;translational proteomics;Trypsin;Validation;Variant

PROJECT_TITLE: Project 1: Discovery of proteins with altered abundance and stability


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: It is largely unknown why some neurons are highly vulnerable to degeneration in early Alzheimer's disease (AD), and why others are not. We have proposed experiments to determine if, and why ectodermal-neural cortex 1 (ENC1) may be responsible for this selective neuronal vulnerability in early AD. The proposed studies will provide mechanistic insight into the role of ENC1 in mediating the degeneration of vulnerable neurons, and identify new therapeutic targets for the prevention and treatment of AD.

PI_NAMEs: FU, HONGJUN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Autophagocytosis;Autophagosome;Autopsy;Bioinformatics;Brain;brain cell;brain control;brain tissue;Cell Nucleus;cell type;Cells;Cerebrum;Cognition;cohort;Cytoplasm;Data;Data Set;design;endoplasmic reticulum stress;entorhinal cortex;excitatory neuron;experimental study;expression vector;Functional disorder;Genes;genetic signature;Genomics;Homeostasis;Human;Huntington gene;Impairment;In Vitro;in vivo;in vivo Model;Individual;inhibition of autophagy;insight;knock-down;Link;LoxP-flanked allele;Maps;Measures;Mediating;Modeling;Molecular;Mus;mutant;neoplastic cell;Nerve Degeneration;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurons;neurotoxicity;new therapeutic target;novel;Nuclear;nuclear factor-erythroid 2;Organoids;overexpression;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;prevent;Prevention;Primary Brain Neoplasms;promoter;Proteins;proteostasis;Regulation;RNA;Role;Signal Pathway;single nucleus RNA-sequencing;Specimen;tau aggregation;tau mutation;tau Proteins;Tertiary Protein Structure;Testing;Transcript;transcriptomics;Transgenic Mice;Work

PROJECT_TITLE: Ectodermal-neural cortex 1 and neuronal vulnerability to tau pathology in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MONTINE, THOMAS J (contact)

PROJECT_TERMS: Abbreviations;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Apolipoproteins;Apoptotic;Biological;Biological Process;Brain;Brain Mapping;Brain region;Cells;Cellular biology;Cellular Structures;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;collaborative approach;Color;Communities;Corpus striatum structure;Cytometry;Data;data dissemination;data sharing;Data Storage and Retrieval;Dementia with Lewy Bodies;Diagnostic;Disasters;Elements;exosome;extracellular vesicles;Flow Cytometry;Formalin;Glutamates;Health;hippocampal pyramidal neuron;Human;human imaging;Image;imaging study;Individual;Infrastructure;Injury;insight;interest;Ions;Lewy Bodies;Lewy neurites;Lipoproteins;Maps;Mass Spectrum Analysis;Medical;microvesicles;mild cognitive impairment;Mitochondria;Monoclonal Antibodies;multiplexed imaging;Multiplexed Ion Beam Imaging;Nervous System Disorder;Neurofibrillary Tangles;Neurons;neuropathology;next generation;Older Population;Paraffin Embedding;Parkinson's Dementia;particle;Pathologic;Pathway interactions;Production;protein distribution;protein TDP-43;Proteins;Proteome;Proteomics;Public Health;Reagent;Reporter;Research;Resources;response to injury;Role;Sampling;Scientist;Senile Plaques;Statistical Data Interpretation;Structure;Subcellular structure;symposium;Synapses;tau aggregation;Testing;Therapeutic;tissue resource;translational proteomics;web portal

PROJECT_TITLE: Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry


PROJECT_TERMS: abeta deposition;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;Bathing;Behavior;Biochemical;Biological;Biological Assay;Biological Markers;biomarker discovery;brain tissue;Cause of Death;Cell Death;Cell Separation;Central Nervous System;Cerebral cortex;Cerebrospinal Fluid;Cessation of life;Clinical;clinical translation;Computer software;Data;Dementia;Deposition;Development;differential expression;Disease;Disease Management;Ensure;Event;experience;extracellular vesicles;gene product;Goals;gray matter;Guidelines;Hand;Impaired cognition;Injury;interest;Laboratories;Lipoproteins;Liquid Chromatography;Liquid substance;Mediator;Methods;mild cognitive impairment;Molecular Conformation;Molecular Weight;Monitor;multiplex assay;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neuronal Dysfunction;Neurons;next generation;novel;novel marker;Outcome;Pathologic;Patients;Phosphorylation Site;Post-Translational Protein Processing;Procedures;Process;protein aggregation;Proteins;Proteomics;regional atrophy;Reproducibility;Research Personnel;Sampling;Senile Plaques;Speed;success;Synapses;tandem mass spectrometry;tau Proteins;tau-1;Tissue imaging;translational proteomics;Validation;verification and validation

PROJECT_TITLE: Project 3: Development of multiplex assays for clinical monitoring of disease


ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: We seek to advance the potential clinical efficacy of a tumor targeting, cell-penetrating antibody that directly inhibits the DNA repair factor, RAD51, and thereby suppresses homology-dependent DNA repair, sensitizes cancer cells to radiation, and mediates synthetic lethality to cancers with mutations in the BRCA2 and PTEN genes. We will do so by a combination of structural, biochemical, cell-based and animal tumor studies to increase the antibody’s ability to inhibit RAD51. This proposal will leverage complementary expertise of the two principal investigators in structural biology of DNA binding proteins and macromolecular machines (Bleichert) and in DNA repair, tumor biology and pre-clinical development of cancer therapeutics (Glazer).

PI_NAMEs: BLEICHERT, FRANZISKA ;GLAZER, PETER M (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Affinity;Amino Acid Substitution;Animals;anti-cancer;Anti-DNA Antibodies;Anti-Idiotype Vaccine;Antibodies;Antineoplastic Agents;Binding;Biochemical;Biochemistry;Biological Assay;Biotechnology;BRCA2 gene;cancer cell;cancer therapy;Cell Nucleus;cell type;Cells;Clinic;Clinical;clinical development;clinical efficacy;Clinical Treatment;Crystallization;design;DNA;DNA Binding;DNA Repair;DNA Repair Inhibition;DNA-Binding Proteins;extracellular;Generations;Goals;Health;Human;improved;In Vitro;in vivo;inhibiting antibody;inhibitor;insight;Institution;Licensing;Lupus;Malignant Neoplasms;Measures;Mediating;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutation;novel;Oligonucleotides;overexpression;Patients;Penetration;Phase I Clinical Trials;phase I trial;preclinical development;Principal Investigator;Property;PTEN gene;Rad51 recombinase;Radiation;Radiosensitization;Reporter;Resolution;Solid Neoplasm;Specificity;structural biology;Structure;Systemic Lupus Erythematosus;Testing;Therapeutic;Time;Tissues;Toxic effect;translational potential;tumor;Tumor Biology;tumor microenvironment;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Structure-Function Studies of a Cell Penetrating Antibody that Inhibits DNA Repair


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: A region found on the midline of the front of the brain, area 25, communicates with areas in the temporal lobe. Balance in this network is disrupted in mood disorders, which emerge early in some young athletes who engage in contact sports. Repeated impact to the head leads to the serious and progressive disease of chronic traumatic encephalopathy (CTE). The proposed research will study the frontal and temporal network to examine how CTE starts and progresses in humans. Information from this study will provide the foundation to develop rational therapeutic methods when the first signs of the disease emerge.

PI_NAMEs: BARBAS, HELEN  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Anatomy;antagonist;Architecture;Area;Axon;axon growth;Behavior;Brain;brain control;Brain Diseases;calbindin;Caliber;calretinin;chronic traumatic encephalopathy;Communication;Confocal Microscopy;contact sports;Data;density;Disease;Distant;Electron Microscopy;Emotional;Emotions;Environment;Equilibrium;excitatory neuron;executive function;experience;Foundations;Goals;Growth Associated Protein 43;Head;Hippocampus;Human;Hyperactivity;inhibitory neuron;innovation;Interoception;Ketamine;Label;light microscopy;Link;Macaca mulatta;Medial;medial temporal lobe;Mediating;Memory;Mental Depression;Mental disorders;Methods;Modeling;Molecular;Monkeys;Mood Disorders;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;Neural Pathways;neurochemistry;Neuroglia;Neurons;nonhuman primate;Parvalbumins;Pathology;Pathway interactions;Pattern;predictive modeling;Prefrontal Cortex;Primates;Process;Progressive Disease;receptor;Research;Resolution;Runaway;Signal Transduction;Statistical Data Interpretation;Statistical Methods;Structural Models;Synapses;System;tau Proteins;Tauopathies;Temporal Lobe;Testing;Therapeutic;Thick;Thinness;Tracer;Variant;white matter

PROJECT_TITLE: Prefrontal Anatomic Pathways in Executive Control

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


PI_NAMEs: BAKER, DAVID  (contact)

PROJECT_TERMS: Affinity;age related neurodegeneration;Age-associated memory impairment;Algorithms;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acids;Amyloid;Amyloid beta-Protein;Antibodies;Binding;Binding Proteins;Biological Assay;Biological Markers;Brain-Derived Neurotrophic Factor;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;Collaborations;data dissemination;data sharing;Data Storage and Retrieval;design;Detection;detection platform;Development;Diagnostic;Engineering;experimental study;Feedback;Functional disorder;Goals;Green Fluorescent Proteins;improved;Length;Logic;Measures;Methods;Molecular;Monoclonal Antibodies;Neurodegenerative Disorders;neurogranin;next generation;novel;Outcome;Parkinson Disease;particle;Peptides;Production;programs;protein biomarkers;Protein Engineering;Proteins;Reagent;Research;Resources;Sampling;Series;Specific qualifier value;Specificity;Statistical Data Interpretation;Surface;System;targeted biomarker;Testing;translational proteomics;Work

PROJECT_TITLE: Project 4: Novel reagent development to enable molecular characterization


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DALLAS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Extracorporeal membrane oxygenation (ECMO) prevents death by supporting the failing heart or lungs and allowing time to heal; -1/3 of ECMO patients do not survive and major neurological injury is common in survivors, leading to long-term neurological deficits. The resulting financial cost and reduction in quality of life place enormous burdens on patients, their families, and society. There are currently no brain monitors which allow clinicians to dynamically adjust ECMO parameters to prevent neurologic injury; the proposed research will demonstrate that continuous quantitative optical monitors of cerebral autoregulation predict neurological injury and inflammation, enabling future development of neuroprotective ECMO protocols.

PI_NAMEs: BUSCH, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acids;Adult;base;Biological Assay;Biological Markers;Blood;Blood flow;blood lead;Blood Pressure;Blood specimen;Brain;brain health;Cardiopulmonary Bypass;cerebral autoregulation;Cerebrovascular Circulation;Cerebrum;Cessation of life;Child;Childhood;Clinical;cohort;conventional therapy;Critical Illness;Critically ill children;cytokine;Development;Diffuse;Disease;Extracorporeal Membrane Oxygenation;Family;Financial cost;Future;Goals;healing;healthy aging;Heart;Hemorrhage;high risk;Homeostasis;Hour;Image;Immunotherapy;Impairment;indexing;Inflammation;Inflammatory;Injury;insight;Intervention;ischemic injury;Knowledge;Lead;Life;Limes;Lung;Measurement;Measures;Mediator;Methods;Monitor;Morbidity - disease rate;mortality;Neonatal;neonatal patient;Nervous System Trauma;neurobehavioral;neuroinflammation;Neurologic;Neurologic Deficit;neuroprotection;novel;Nursery Schools;Optics;Outcome;Pathway interactions;Patients;pediatric patients;Perfusion;Pilot Projects;point of care;Population;prevent;prospective;protocol development;Protocols documentation;Quality of life;recruit;Research;Risk;School-Age Population;Scientist;Secondary to;Societies;Spectrum Analysis;Speed;Survivors;Systemic blood pressure;temporal measurement;Testing;Time;timeline;Titrations;tool;Up-Regulation;Work

PROJECT_TITLE: Development of quantitative optical tools to continuously monitor cerebral autoregulation, blood flow, oxygenation and inflammation during pediatric extracorporeal life support


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Collegiate recovery programs provide support for students in recovery from addiction as well as students seeking to recover. They’ve spread rapidly, but little is known about their availability, effectiveness, best practices, and utilization. In this project, I will describe collegiate recovery programs, identify their core elements, chart their national spread and draw conclusions about how they can be scaled up and evaluated.

PI_NAMEs: VEST, NOEL ADAM (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: addiction;Address;Administrator;Affect;Area;Attention;Award;California;career;career development;Characteristics;Clinical;clinical training;Collaborations;college;Communities;comparative;Consolidated Framework for Implementation Research;design;Development;Effectiveness;Elements;emerging adult;emerging adulthood;Enrollment;Ethnography;evidence base;Evidence based intervention;Evolution;experience;Experimental Psychology;Funding;Geography;Goals;Grant;Harm Reduction;Health;higher education;implementation intervention;implementation science;improved;Individual;innovation;insight;Institution;Interdisciplinary Study;Interview;Investments;Knowledge;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Morphologic artifacts;National Institute of Drug Abuse;Nature;Online Systems;Outcome;Population;Preventive;Professional counselor;programs;Proliferating;Public Health;Publications;Qualitative Methods;Recovery;Reporting;Research;Research Methodology;Research Personnel;Safety;scale up;Schools;Science;Services;skills;statistics;Structure;Students;substance use;Substance Use Disorder;Surgeon;Surveys;sustained recovery;Testing;Texas;Time;Training;trend;United States National Institutes of Health;Universities;university student;Update;Work;Writing

PROJECT_TITLE: Collegiate recovery programming in the U.S.: An implementation science and mixed methods study

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Genetics;Physical Rehabilitation;Rehabilitation;Sarcopenia

ORG_CITY: EUGENE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Age-related muscle atrophy and contractile dysfunction have been well described at the cellular level, but the molecular mechanisms that contribute to this dysfunction are poorly understood. Improved understanding of these mechanisms is critically important for the improvement of physical rehabilitation in older adults at risk for mobility impairment and physical disability. Our studies will pursue pre-clinical evidence that post translational modification of specific proteins in skeletal muscle lead to an “aging phenotype” in skeletal muscle that may unlock new strategies for improving physical function in older adults with physical frailty.

PI_NAMEs: CALLAHAN, DAMIEN MARK (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Actins;Acute;Address;Adult;Age;age difference;age effect;age related;age related changes;Aging;Area;Atrophic;Binding;Biology;Cardiac;Cell Respiration;Characteristics;Clinical;Coupling;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Exhibits;experience;experimental study;Failure;fall risk;Fatigue;Fiber;frailty;Functional disorder;genetic regulatory protein;Goals;Heart;Heart failure;Human;Impairment;improved;In Vitro;in vivo;interest;Intervention;Isometric Contraction;Isometric Exercise;Kinetics;Lead;Life;life span;Mediating;Mobility decline;Mobility disability;Modification;Molecular;Molecular Target;Muscle;muscle aging;Muscle Cells;Muscle Fibers;muscle form;Muscle function;Muscle Tension;Muscular Atrophy;Myocardial;Myosin ATPase;Myosin Regulatory Light Chains;myosin-binding protein C;novel;older adult;Outcome;Performance;Phenotype;Phosphorylation;Physical Function;physical impairment;Physical Rehabilitation;physically handicapped;Post-Translational Protein Processing;pre-clinical;preclinical study;Protein Dephosphorylation;Protein Isoforms;Proteins;Rehabilitation Outcome;Reporting;Research;Resistance;Risk;Role;Sarcomeres;sarcopenia;screening;Sequence Homology;skeletal;Skeletal Muscle;skeletal muscle wasting;Testing;Thick Filament;Thin Filament;Tissue Sample;Tissues;Translating;Walking;young adult

PROJECT_TITLE: Protein modification and the aging phenotype of human skeletal muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Newark

ORG_DEPT: NEUROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: In old age, apathy is a strong predictor of cognitive decline and dementia, and is associated with increased burden of ADRD-related brain characteristics. However, its role as a marker for incipient dementia in midlife, a critical time point for intervention, has not been studied. This study will investigate the cognitive and ADRD- related brain correlates of apathy components (based on subjective and objective measures) in middle-aged, cognitively normal offspring of ADRD patients, and is anticipated to enable the development of apathy as an accessible behavioral screening tool for identifying individuals at high risk for ADRD.

PI_NAMEs: RAVONA, RAMIT ;SCHNAIDER BEERI, MICHAL  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Affect;Age;age group;aging population;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Autonomic nervous system;Behavior;Behavior assessment;Behavioral;behavioral impairment;Behavioral Symptoms;Biological;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;brain volume;cerebral atrophy;Cerebrovascular Disorders;Characteristics;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;critical period;Curiosities;Data;Dementia;Development;Devices;diagnostic accuracy;Dimensions;Disease;disorder risk;Emotional;Eye;frontal lobe;Functional Magnetic Resonance Imaging;gaze;Genetic;Goals;Health;Health Services;high risk;human old age (65+);imaging biomarker;Impaired cognition;Individual;informant;innovation;Intervention;Investments;Israel;Knowledge;Life;Life Style;Link;longitudinal design;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical center;medical schools;Mental Depression;middle age;Neurobiology;offspring;older adult;Parietal;Participant;Pathology;Patients;Personality;PET/CT scan;Phenotype;Photic Stimulation;Physical activity;preventive intervention;Questionnaires;Recording of previous events;Registries;Reporting;Rewards;Risk;Role;Screening procedure;Signal Transduction;smartphone application;social;Stimulus;tau Proteins;Testing;Time;visual stimulus;White Matter Hyperintensity;willingness;young adult;β-amyloid burden

PROJECT_TITLE: Cognitive and brain imaging correlates of apathy- components in asymptomatic middle aged individuals at high ADRD- risk

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative The obesity epidemic has led to an increased risk for youth to develop type 2 diabetes, particularly during puberty and in minority populations. There is a need to comprehensively understand the underlying pathophysiology of T2D progression in youth to identify those at the highest risk for developing T2D as well as any modifiable exposures and determinants of T2D progression and how these factors differ regarding sex or race/ethnicity. With the power of this large clinical consortium, the development of a structured risk score analysis can be achieved to help identify youth at the greatest risk and optimize interventions during this critical developmental period designed for long-term prevention of type 2 diabetes.

PI_NAMEs: GORAN, MICHAEL ISAAC (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Abdomen;Adipose tissue;Adolescent;Adult;Air Pollutants;Air Pollution;Beta Cell;biobank;Biochemical Markers;Bioinformatics;Biological;biomarker discovery;biomarker identification;Biopsy;Body fat;California;Cell Physiology;Child;Childhood;Childhood diabetes;Clinical;clinical center;cohort;Collaborations;Collection;community partners;Continuous Glucose Monitor;critical developmental period;Data;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diagnostic criteria;Diet;Dietary Sugars;DNA;Dual-Energy X-Ray Absorptiometry;Endocrine Disruptors;Environmental Exposure;Environmental Risk Factor;Enzymes;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Family;Family dynamics;Family history of;Fasting;Fatty acid glycerol esters;Feces;food environment;Functional disorder;Funding;Future;Gender;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Gonadal Steroid Hormones;Health;Health Food;high risk;Image;improved;Individual;Inflammatory;Insulin Resistance;insulin secretion;Intervention;Investigation;Knowledge;Latino;Latino Population;Life Style;Lipids;Liver;Longitudinal Studies;Los Angeles;Magnetic Resonance Imaging;Measurement;Measures;Medical Care Costs;Metabolic;Metabolic Marker;metabolic phenotype;Methods;Minority Groups;Modeling;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nutritional;Obesity;Obesity Epidemic;obesity risk;OGTT;Outcome Measure;Pancreas;Participant;Physical activity;Plasma;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Populations at Risk;Predictive Factor;predictive marker;Predisposition;Prevention;Prevention strategy;Protocols documentation;Puberty;Publications;Race;recruit;Resources;Risk;Risk Factors;risk prediction;Saliva;Sampling;screening;sex;Site;Sleep;social determinants;social factors;social health determinants;specific biomarkers;Structure;subcutaneous;Subgroup;Time;tool;Underserved Population;Urine;Visceral;Work;Youth

PROJECT_TITLE: Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Immune-mediated inflammatory diseases of the intestines, such as IBD, are mediated by CD4 T cells with poorly restrained reactivity to the enteric microbiota. Here, we will advance understanding of mechanisms that control the development of peripheral regulatory T (pTreg) cells into mature, effector Treg (eTreg) cells that can act therapeutically to reverse intestinal inflammatory disease. We expect that results from these studies will our proposal will establish new biological paradigms and inform interventions to curb pathogenic immunity to the microbiota in IBD.

PI_NAMEs: HATTON, ROBIN D;WEAVER, CASEY T (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Amplifiers;Autoantigens;Biological;Biology;Calibration;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Maintenance;Cells;Chemosensitization;Clinical Trials;Clinical Trials Design;Colitis;commensal microbes;Competence;cytokine;Development;Disease;disorder risk;early onset;effector T cell;Environment;Equilibrium;Eragrostis;Fibrosis;food antigen;FOXP3 gene;GATA3 gene;Gene Expression;Gene Targeting;Generations;Genes;Genetic study;gut inflammation;gut microbiota;Homeostasis;Human;Human Genetics;IL10RB gene;IL17 gene;IL2 Signaling Pathway;Immune;Immune system;Immunity;immunoregulation;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Interleukin 2 Receptor;Interleukin-10;interleukin-10 receptor;Interleukin-2;Intervention;Intestines;knock-down;Large Intestine;Lesion;Maintenance;man;Mediating;member;Methods;microbiota;mouse model;Mus;Mutation;Myeloid Cells;novel;novel strategies;novel therapeutic intervention;Output;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral;Play;pleiotropism;Population;Production;programs;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;response;restraint;Role;Signal Pathway;Signal Transduction;Source;STAT3 gene;Stat5 protein;synergism;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Thymus Gland;Tissues;TNF gene;TNFSF15 gene;transcription factor;Transcriptional Regulation;Tumor Necrosis Factor Receptor

PROJECT_TITLE: Mechanisms Controlling the Development and Function of Intestinal Effector Treg cells

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Therapeutic targeting of SARS-CoV-2 will likely need a combination of antiviral agents in addition to a vaccine: we propose to develop an antiviral agent that targets SRAS-CoV-2 PLpro vital to virus survival.

PI_NAMEs: XIONG, RUI  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Active Sites;Address;Affinity;Animal Model;Anti-viral Agents;anti-viral efficacy;antiviral drug development;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;Caspase;Cell model;Cells;Complement;Complex;COVID-19 pandemic;COVID-19 treatment;current pandemic;Cysteine;Data;design;Development;Distal;Dose;drug candidate;drug discovery;Drug Exposure;Drug Kinetics;Ensure;Enzyme Inhibition;expectation;future outbreak;Glycine;Goals;Human;Immune;Impairment;improved;in silico;In Vitro;in vivo;inflammatory marker;inhibitor;Innate Immune Response;insight;Interferon Type I;intraperitoneal;Intraperitoneal Injections;Lead;Ligand Binding;Lung;meter;Microsomes;Modeling;mouse model;Mus;nanomolar;novel;Oral;Papain;Peptide Hydrolases;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Polyproteins;Positioning Attribute;pre-clinical;programs;Property;prophylactic;Protease Inhibitor;Research;Roentgen Rays;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;scaffold;Series;Site;small molecule;socioeconomics;Solubility;Structure;Surface;targeted agent;Testing;therapeutic target;Toxicology;Treatment Efficacy;Triage;Vaccination;Vaccines;Variant;Viral;Viral Load result;Viral Physiology;Viral Proteins;Virus;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Targeting SARS-CoV-2 PLpro for COVID-19 treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study will examine how metabolism within specific host organs and the resulting metabolites within those host environments affect the virulence potential of Fusobacterium nucleatum, a key colonizer in the development of dental plaque and a pathogen linked to both pre-term birth and colorectal cancer. A better understanding of these host-pathogen relationships is needed to unveil critical new targets for developing anti-infective therapies so as to treat and prevent significant diseases that are associated with this pathogen.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acetaldehyde;Acetyl Coenzyme A;adverse pregnancy outcome;Affect;Amniotic Fluid;Anaerobic Bacteria;Anti-Infective Agents;Applications Grants;Bacterial Adhesins;Binding;Biochemistry;Bioinformatics;Carbon;Catabolism;Cell membrane;Cells;Chorionic villi;Code;Colon;Colorectal Cancer;comparative;Data;Dental Plaque;Development;differential expression;Disease;Distal;Encapsulated;Environment;Environmental Risk Factor;Enzymes;Escherichia coli;Ethanolamine Ammonia-Lyase;Ethanolamines;fetal;Fetal Development;Fetal Tissues;Fetus;First Pregnancy Trimester;Functional disorder;Fusobacterium nucleatum;Future;Gal-GalNAc;Gene Cluster;Genes;Genetic;genetic approach;Genetic Determinism;Goals;Growth;Hematogenous;Human;Hypothetical Protein;Immunity;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Knowledge;Link;Malignant Breast Neoplasm;Mediating;Metabolic;Metabolism;Molecular;Mothers;mouse model;Mouth Diseases;Mus;mutant;Nitrogen;Odontogenesis;oral biofilm;Organ;Organelles;Organism;Parents;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Phosphatidylethanolamine;Phospholipids;Placenta;Play;polymicrobial biofilm;Pregnancy Complications;Premature Birth;prevent;Proteins;public health relevance;pup;Reporting;response;Role;Salmonella;Signal Transduction;Signaling Molecule;Site;Source;stillbirth;Structural Protein;Survival Rate;symbiont;System;Testing;therapeutic target;Third Pregnancy Trimester;Time;Toxic effect;transcriptome sequencing;Umbilical Cord Blood;Virulence;Virulence Factors;Work

PROJECT_TITLE: Metabolic modulation of Fusobacterium nucleatum virulence


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. This study utilizes high-speed optical coherence tomography (OCT) technology at the bedside of very preterm infants in the intensive care nursery, to characterize previously unseen abnormalities that can lead to poor visual development or can be indicators of poor neurological development. Our long-term goal is to help improve preterm infant health and vision via objective bedside imaging and analysis that characterizes early critical indicators of ROP and its response to treatment, poor visual function and neurological development, which will rapidly translate to better early intervention and improved future vision care.

PI_NAMEs: TOTH, CYNTHIA ANN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Achievement;Address;advanced analytics;Aftercare;Age;Angiography;Blindness;Blood Vessels;Brain;Caring;Child;Childhood Acute Lymphocytic Leukemia;Clinical;clinical care;Clinical Trials;cohort;Communication;Computer software;Cornea;cost;Darkness;Data;Data Pooling;Data Set;Databases;design;Development;Disease;Disease Pathway;Disease Progression;Documentation;Early Intervention;Ensure;Evaluation;Evolution;extreme prematurity;Eye;Feedback;Fostering;Friends;Fundus;Future;Goals;Grant;Health;high risk;Human;Image;imager;improved;Infant;Infant Care;Infant Health;information gathering;insight;Intensive Care;interest;Investigation;lens;Light;Methods;Microanatomy;Monitor;Morphology;Multivariate Analysis;Neural Retina;neurodevelopment;Neurologic;neurovascular;next generation;Nurses;ophthalmic examination;Optical Coherence Tomography;Optical Methods;Outcome;outcome prediction;Output;Pathologic;Perinatal;Photography;Physicians;Pigmentation physiologic function;Population Heterogeneity;Prediction of Response to Therapy;Premature Infant;preterm newborn;Process;programs;Recurrence;Recurrent disease;Reference Standards;Reproducibility;Research;Retina;Retinopathy of Prematurity;Retreatment;Risk;School-Age Population;Science;Scientist;screening;Speed;Stress;Technology;Telemedicine;Test Result;Testing;Therapeutic;Time;tool;Translating;treatment and outcome;treatment response;vascular abnormality;Vision;vision development;Visual impairment

PROJECT_TITLE: Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

PHR: Narrative Understanding how microbes may regulate the expression of virulence factors when directly encountering another cell type requires single-cell resolution however there are many technical and biological barriers to achieving this for bacteria. Here we propose to leverage a recent breakthrough in single-cell transcriptomics (scRNAseq) that has been developed for prokaryotes designated MicroSPLiT to study these cell-cell interactions.

PI_NAMEs: KUCHINA, ANNA ;MCLEAN, JEFFREY SCOTT (contact)

PROJECT_TERMS: Acute;Address;Affect;Architecture;Bacteria;Bacterial Adhesins;Bar Codes;Binding;Biological;Biological Models;Bypass;Cell Communication;Cell Separation;Cell Size;cell type;Cell Wall;Cells;clinically relevant;Coculture Techniques;combinatorial;Communities;Complex;cost;dental biofilm;design;differential expression;Disease;Environment;Eukaryota;experimental study;extracellular;fungus;Fusobacterium nucleatum;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Homeostasis;Human Microbiome;human microbiota;In Vitro;in vivo Model;innovation;insight;instrumentation;interest;laboratory equipment;Life Style;Ligation;Measures;member;Messenger RNA;Methodology;Methods;Microbe;microbial;Microbiology;microbiota;Microfluidics;microorganism interaction;Modeling;Modernization;Morphology;Noise;novel;Oral;oral bacteria;Oral cavity;oral microbial community;Organism;Outcome;Parasites;Pathogenicity;Pathway interactions;Peptidoglycan;periodontopathogen;Porphyromonas gingivalis;Probability;Prokaryotic Cells;Protocols documentation;Radiation;Research;Resolution;RNA;Sampling;Science;Signal Transduction;single-cell RNA sequencing;Stress;Study models;System;Techniques;Technology;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;Viral;Virulence;Virulence Factors

PROJECT_TITLE: Resolving Oral Bacteria Interactions with a High-Throughput Low-Cost Single-Cell Transcriptomics Approach

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Tuberculosis (TB) remains a leading cause of death from infectious diseases globally. Understanding why some infected individuals develop disease and others do not is paramount to developing preventative treatments. We discovered an unexpected association between TB susceptibility and inhibition of tyrosine metabolism, which could be leveraged as a novel target for preventative therapy against TB progression.

PI_NAMEs: SULIMAN, SARA  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acetoacetates;Acute;acute infection;Adoptive Transfer;African;Amino Acids;Aromatic Amino Acids;biobank;Biological Assay;Catabolism;Cause of Death;Cells;Citric Acid Cycle;cohort;Collaborations;Communicable Diseases;Complement;CRISPR/Cas technology;Data;Data Set;Defect;Dendritic Cells;Development;Disease;Disease Progression;Down-Regulation;Enrollment;Enzymes;Exhibits;experimental study;extracellular;Fetal Liver;Fumarates;Fumarylacetoacetase;Future;Generations;Genes;Genetic Polymorphism;genetic variant;Genotype;Genus Hippocampus;Glycolysis;Growth;Hematopoietic;Hematopoietic stem cells;Hepatocyte;Hereditary Disease;high risk;Household;Human;Hydrolysis;Immune Evasion;Immune response;immunoregulation;Impairment;In Vitro;in vivo;Individual;Infection;Inflammatory;Intervention;Isotope Labeling;Knock-out;Longitudinal cohort;Macrophage;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;monocyte;mortality;Mus;Mycobacterium tuberculosis;Myeloid Cells;Myeloid Progenitor Cells;Nitric Oxide;Nitrogen;novel;Nutrient;Oxidative Phosphorylation;pathogen;Pathogenesis;Pathway interactions;Patients;permissiveness;Persons;Peruvian;Phagocytes;Phase;Phenylalanine;Phenylalanine Metabolism Pathway;Plasma;Predisposition;Preventive therapy;Preventive treatment;Production;prophylactic;prospective;Publishing;Recording of previous events;Resolution;response;Risk;Role;Sampling;Series;Serum;Supplementation;Testing;transcriptome sequencing;Transgenic Organisms;Tuberculosis;Tyrosine;Tyrosine Metabolism Pathway;uptake;Variant;Virulence

PROJECT_TITLE: The role of tyrosine metabolism in tuberculosis pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Biotechnology;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research is relevant to public heath because activation of the complement system contributes to injury in a wide range of kidney diseases. Standard immunosuppressive drugs are not effective at preventing injury by the complement system, and complement-targeted drugs increase the risk of infection. The therapeutic agents tested in these experiments may offer an important new approach to treating renal disease.

PI_NAMEs: THURMAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Affinity;Alternative Complement Pathway;Annexins;antagonist;Antigen-Antibody Complex;Autoantibodies;Autoimmune Responses;B-Lymphocytes;Basement membrane;Binding;blocking factor;Cells;Complement;Complement 3a;Complement 5a;Complement Activation;Complement Factor B;Complement Factor D;Complement Factor H;Complement Inactivators;complement system;Consumption;Defect;Deposition;design;Drug Targeting;Equilibrium;Event;experimental study;Exposure to;Feedback;Genes;glomerular basement membrane;Glomerular Capillary;Glomerulonephritis;Grant;Hemolytic-Uremic Syndrome;IGA Glomerulonephritis;Immune;Immunity;Immunosuppressive Agents;In Vitro;in vivo Model;infection risk;Inflammation;Inflammatory;Injury;Injury to Kidney;Kidney;Kidney Diseases;Kidney Failure;Ligation;Location;Lupus Nephritis;Mediating;Membranous Glomerulonephritis;Molecular;Mutation;Myeloid Cells;novel;novel strategies;novel therapeutics;Organ;Pathologic Processes;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Plasma;Predisposition;prevent;Probability;Process;Production;protective pathway;Protein Engineering;Proteins;Public Health;Publishing;receptor;Renal glomerular disease;Research;Site;Surface;T-Lymphocyte;Testing;Therapeutic Agents;Tissues;Work

PROJECT_TITLE: Complement-mediated injury of the kidney: New mechanisms and novel therapies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: Loss of limbal stem cells or destruction of the limbal stem cell niche can result in limbal stem cell deficiency, a common cause of vision loss in the world. The two Aims of this proposal will: mechanistically dissect the role of FGF7, BMP2 and AXL in the LSC maintenance using murine and human genetically engineered experimental models (Aim 1) and will test the therapeutic potential of targeting these pathways for the treatment of LSCD in pre-clinical murine disease models (Aim 2). Successful completion of  this study will further advance our understanding of LSC development, maintenance, and regulation with significant implications  for clinical translation.

PI_NAMEs: SASAMOTO, YUZURU  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Admixture;Allogenic;Area;ATP-Binding Cassette Transporters;Autologous;Autologous Transplantation;Bilateral;Binding;Blindness;BMP2 gene;CAV1 gene;Cell Maintenance;cell regeneration;Cell Separation;Cell Survival;Cells;Clinical;clinical training;clinical translation;Clinical Trials;conjunctiva;Contralateral;Cornea;corneal epithelium;Development;disease model;Doctor of Philosophy;experience;Experimental Models;Eye;fascinate;FDA approved;FGF7 gene;FGFR2 gene;Fibroblast Growth Factor;Genes;Genetic Engineering;Goals;Homologous Transplantation;Human;improved;In Vitro;in vivo;induced pluripotent stem cell;Instruction;interest;limbal;Maintenance;member;Mentorship;Modeling;Molecular;morphogens;Mus;Natural regeneration;novel;Ophthalmologist;Ophthalmology;Organ;Pathway interactions;Patients;Phase;Phenotype;pre-clinical;Receptor Protein-Tyrosine Kinases;recruit;regeneration potential;Regenerative Medicine;Regulation;Research;Research Personnel;restoration;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell biology;stem cell biomarkers;Stem Cell Development;stem cell homeostasis;stem cell niche;stem cell population;stem cell self renewal;Stem cell transplant;stem cells;stemness;success;Testing;Therapeutic;therapeutic evaluation;Tissues;Topical application;Training;Undifferentiated;Vocational Guidance

PROJECT_TITLE: Development of cell-free approaches to the treatment of limbal stem cell deficiency

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Sleep Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Memory impairment is a core, disabling feature of schizophrenia, yet we lack effective treatments. While most studies of memory focus on active learning, it is now clear that much of memory formation happens without conscious awareness, during restful wake and sleep, and depends on a deep brain structure called the hippocampus. The primary objectives of the proposed research program are to test the hypotheses that in schizophrenia, hippocampal dysfunction gives rise to offline memory deficits and can be treated with closed-loop auditory stimulation during sleep (CLASS), a novel, noninvasive brain stimulation technique that can be implemented at home.

PI_NAMEs: MANOACH, DARA S (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acoustic Stimulation;Active Learning;Address;Amnesia;Animals;archived data;Autopsy;Awareness;Brain;Chronic;Clinic;Cognition;Cognitive deficits;cognitive disability;Conscious;Coupled;Coupling;Data;Data Set;density;Disabling;effective therapy;Electroencephalography;Epilepsy;Eszopiclone;experience;Explosion;Fingers;forgetting;Functional disorder;Generations;Goals;Grant;Health;Hippocampus;Home;Human;Impairment;improved;improvement on sleep;Interneurons;Intervention;Knowledge;Laboratories;Learning;life span;Link;machine learning classifier;Magnetic Resonance Imaging;Measures;Medical;Memory;memory consolidation;Memory impairment;Memory Loss;memory process;Monitor;Motor;motor learning;mouse model;MRI Scans;neglect;neuroimaging;noninvasive brain stimulation;novel;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Physiology;Play;Polysomnography;Prefrontal Cortex;preservation;Process;programs;Research;Rest;Rodent;Role;Scalp structure;Schizophrenia;sequence learning;Sleep;sleep spindle;Structure;Techniques;Testing;Thalamic structure;Training;Translating;virtual;Wakefulness;Work

PROJECT_TITLE: Offline memory processing in schizophrenia


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Mutations in the metabolic enzyme IDH1 cause epigenetic deregulation, suppress cellular differentiation and define the majority of grade II, III gliomas and the glioblastomas that progress from these lower grades. Treatment with demethylating and other drugs demonstrates benefit in orthotopic IDH1 mutant animal models. This project goal is to further preclinical development of combination therapy for recurrent IDH1 mutant gliomas, including therapies suitable for early intervention to halt progression, and define which molecular mechanisms are responsible for response to therapy.

PI_NAMEs: RIGGINS, GREGORY JOSEPH (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: acquired drug resistance;alpha ketoglutarate;Animal Model;anti-cancer;Apoptosis;Apoptotic;Azacitidine;Brain;Brain Neoplasms;Canis familiaris;CASP3 gene;Cell Aging;Cell Differentiation process;Cell division;cell growth;Cell Line;Cell Proliferation;Cells;Characteristics;Clinical Trials Design;Combined Modality Therapy;Data;demethylating therapy;demethylation;Differentiation Antigens;Differentiation Therapy;Disseminated Malignant Neoplasm;DNA;DNA Damage;driver mutation;Early Intervention;efficacy evaluation;Enzymes;Epigenetic Process;FDA approved;Future;Gene Expression;Gene Expression Profile;Genes;Genomic DNA;Glioblastoma;Glioma;Goals;Grant;Histones;Human;Hypermethylation;improved;In Vitro;in vivo;in vivo Model;Induced Mutation;Induction of Apoptosis;Intracranial Neoplasms;Isocitrate Dehydrogenase;leukemia;Malignant Glioma;Malignant Neoplasms;Metabolic;Methylation;Modeling;Molecular;mouse model;mutant;Mutation;Neuroglia;novel;Pathogenicity;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase II Clinical Trials;pre-clinical;preclinical development;preclinical efficacy;preclinical study;prevent;Production;Publications;Radiation;Recurrence;response;Risk Reduction;Rodent;Safety;senescence;Signal Transduction;small molecule;Speed;standard of care;stem cell biomarkers;subcutaneous;synergism;targeted treatment;temozolomide;Testing;Therapeutic;Toxic effect;treatment optimization;treatment response;Tretinoin;tumor;Tumor Burden;tumor growth;Tumor Suppressor Genes;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Optimizing demethylating therapy for IDH1 Mutant Malignant Gliomas

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Opioid related deaths have become the leading cause of death among postpartum women through 12 months after delivery; treatment for opioid use disorder with medications and behavioral therapies reduce overdose risk and improve outcomes, but treatment continuation and its effectiveness at strengthening recovery de- creases rapidly after delivery. This career development award will gather patient reported data to guide revi- sions of a pre-existing battery of measures intended to capture an individual’s multidimensional profile at the pregnancy to postpartum transition feasibly in a clinical environment. We will then assess how mechanisms of recovery vary across these profiles through 1 year after delivery in order to inform subsequent clinical trials of individualized treatment regimens for postpartum women with opioid use disorder.

PI_NAMEs: MARTIN, CAITLIN EILEEN (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Abstinence;addiction;Address;alcohol use disorder;Alcohols;antidepressant effect;Anxiety;Area;Behavior Therapy;behavioral health;Biological;biopsychosocial;biopsychosocial factor;Birth;Buprenorphine;career;Cause of Death;Child;Child Custody;Clinical;clinical application;clinical care;Clinical Trials;Cohort Studies;Collaborations;Data;Data Reporting;Development;Dimensions;Dose;Effectiveness;Emotional;Environment;Ethics;Event;evidence base;Face;fourth trimester;Funding;Future;Goals;Gynecologist;Impairment;improved;improved outcome;Impulsivity;Individual;individualized medicine;Infant Health;innovation;insight;Insurance;interest;Interview;K-Series Research Career Programs;Knowledge;Life Cycle Stages;Measures;medical specialties;medication for opioid use disorder;Medicine;Mental Depression;Mentorship;Moods;National Institute of Drug Abuse;Neonatal;neurobehavioral;Neurobiology;novel strategies;Opioid;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;Patients;Pattern;Perinatal;perinatal period;personalized approach;personalized medicine;Pharmaceutical Preparations;Phenotype;Physically Challenged;Physicians;Pilot Projects;Population;Postpartum Period;Postpartum Women;Pregnancy;pregnancy related death;prenatal;Prenatal care;programs;promoter;prospective;Provider;psychologic;psychosocial;Psychosocial Factor;Qualitative Methods;Quality of Care;Quality of life;Recovery;Recovery Support;Regimen;Reporting;Research;Research Methodology;Research Personnel;Resources;routine care;Science;Scientist;Services;skills;social;Social Work;Statistical Data Interpretation;Stress;stressor;Structure;substance use;targeted treatment;Testing;Therapeutic;Time;Training;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;Withdrawal;Woman;Women's study;women's treatment;Work

PROJECT_TITLE: Adaptation and Refinement of a Clinically Applicable Phenotypic Battery to Individualize Opioid Use Disorder Treatment for Women Through the Postpartum Period

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The goal of this exploratory project is to utilize high throughput screening (HTS) along with a physiologically relevant model system to identify unique small molecules that selectively and allosterically modulate bradykinin B1 receptors for effective treatment of a multitude of disorders (e.g., inflammation, edema, asthma, pain).

PI_NAMEs: BERG, KELLY ANN;CLARKE, WILLIAM P (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Affinity;Agonist;antagonist;Asthma;Biological Models;Bradykinin;Cells;Chemicals;chronic pain;Clinical Trials;Core Facility;Data;Diabetic Retinopathy;Disease;drug action;drug development;Drug Targeting;drug-like compound;Edema;effective therapy;efficacy testing;Evaluation;experimental analysis;Exposure to;Failure;Future;Goals;Health;high risk;high throughput screening;Human;Human Activities;in vivo;Inflammation;Inflammation Mediators;innovation;Kallidin;Libraries;Ligands;lung microvascular endothelial cells;Malignant Neoplasms;Neuropathy;Normal tissue morphology;novel;Obesity;Pain;Pathologic;Pathology;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Physiological;Pre-Clinical Model;Property;receptor;receptor expression;receptor function;Reporting;Rodent;Role;Safety;screening;small molecule;small molecule libraries;species difference;Specificity;Structure-Activity Relationship;Testing;Therapeutic;Therapeutic Agents;therapeutic development;Therapeutic Uses;therapeutically effective;Tissues;Toxic effect;Vascular Diseases;Work

PROJECT_TITLE: Negative allosteric modulators for bradykinin B1 receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(03)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  The purpose of this training program is to provide a short-term, intensive research experience related to hearing, vestibular, cognition, and/or speech/language sciences for audiology doctoral (AuD) students. The overarching goal is to provide AuD students with the experience and encouragement to consider a PhD or otherwise pursue clinical/translational research careers to address the shortage of clinician-scientists in the field. Regardless of the trainees’ eventual career choice, the research experience obtained through this training program will enhance clinical service delivery to the approximately 48 million individuals in the United States with hearing loss.

PI_NAMEs: JANKY, KRISTEN L. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: American;Audiology;Auditory;boys;career;Clinical;Cognition;community engagement;Computer software;Data Collection;design;Doctor of Philosophy;doctoral student;Environment;Event;experience;Extramural Activities;Faculty;faculty mentor;Grant;Hearing;hospital laboratories;Hospitals;Human Resources;human subject;Interdisciplinary Study;Journals;Laboratories;Language;Measurement;Measures;meetings;member;Mentors;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;Process;programs;Publications;Questionnaires;recruit;Reporting;Research;research faculty;Research Project Grants;Research Training;Resources;Science;Societies;Speech;Statistical Data Interpretation;Students;success;Technology;Traineeship;Training;Training Programs;Translational Research;Underrepresented Populations;Universities;vestibular system;Work

PROJECT_TITLE: Short-Term Research Training for AuD Students


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Principal Investigator: Li, Jun  Demyelination removes segments of myelin along the nerve fibers. This pathology occurs in a group of neurological disorders with collectively high prevalence. In this study, we will test a novel mechanism upstream to segmental demyelination by disrupting myelin junctions. We will explore treatment to stop the disruption of myelin junctions, preventing myelin from being removed (demyelination). 1

PI_NAMEs: LI, JUN  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Action Potentials;Affect;Axon;Binding;Cell membrane;cell type;Cells;Characteristics;Chronic Inflammatory Demyelinating Polyneuropathy;Cyclic AMP;Data;Demyelinating Diseases;Demyelinations;Development;Disease;dysmyelination;effective therapy;Event;Excision;Family member;Functional disorder;GTP-Binding Protein beta Subunits;GTP-Binding Proteins;Guillain Barré Syndrome;Hereditary neuropathy with liability to pressure palsies;High Prevalence;Hyperactivity;Inherited;kinase inhibitor;Knock-out;Lead;Maintenance;Modeling;Molecular Target;molecular targeted therapies;mouse model;Multifocal Motor Neuropathy;Multiple Sclerosis;Mus;Myelin;Myelinated nerve fiber;myelination;Nerve;Nerve Fibers;Nervous System Disorder;Neuroglia;novel;p21 activated kinase;p21-activated kinase 1;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peripheral Nerves;Peripheral Nervous System Diseases;Permeability;Phenotype;Phosphotransferases;Play;PMP22 gene;Polyneuropathy;prevent;Principal Investigator;protein complex;Proteins;Regulation;remyelination;repaired;Role;Schwann Cells;seal;Second Messenger Systems;Surrogate Markers;targeted treatment;Testing;therapy development

PROJECT_TITLE: Myelin Junction Therapy in Peripheral Neuropathies

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Genetics;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: PROJECT NARRATIVE Environmental arsenic is a major public health concern, and early life exposure to arsenic from well water or food increases adult risk of developing of psychiatric disorders such as depression and anxiety in adulthood, by unknown mechanisms. This project will test the hypothesis that early life exposure to arsenic increases risk of developing psychiatric disorders by perturbing developmental gene expression in the brain, resulting in persistent glucocorticoid resistance and impeded regulation of neuroinflammation and stress responsivity across the lifespan.

PI_NAMEs: COFFMAN, JAMES A (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acute;Adult;Affect;Animals;antagonist;Anxiety;Arsenic;Behavior;Behavioral;Biological;Biological Models;Brain;brain tissue;Cellular Stress;Chronic;Circadian Rhythms;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;Dependence;Development;Developmental Gene;early life exposure;Embryo;Endocrine;Endocrine Disruptors;Environment;Environmental Exposure;environmental stressor;experimental study;Exposure to;Feedback;Fishes;Fluorescence Microscopy;Food;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Markers;Glucocorticoid Receptor;Glucocorticoids;Goals;Homologous Gene;Human;Hydrocortisone;Hypothalamic structure;in vivo imaging;Inflammation;Inflammatory;inflammatory marker;insight;Knock-out;Larva;Life;life span;Link;loss of function;Measures;Mediating;Mental Depression;Mental disorders;Metabolic;Metabolism;Mineralocorticoids;Monitor;Movement;mutant;Nerve Degeneration;neurogenesis;neuroinflammation;Neurons;Neurosecretory Systems;NF-kappa B;Nuclear Receptors;Output;Pathway interactions;Physiological;Pituitary Gland;Pituitary-Adrenal System;Positioning Attribute;prenatal;Psychology;Psychopathology;Public Health;receptor function;Receptor Signaling;Regulation;Regulatory Pathway;Reporter Genes;Research;Research Project Grants;Resistance;response;Risk;Signal Pathway;Signal Transduction;social;stem;Stress;stressor;Structure;System;Testing;tool;transcription factor;Transgenic Organisms;well water;Zebrafish

PROJECT_TITLE: Long-term risk for psychiatric disorders following early life exposure to environmental arsenic

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (PD)]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BOSTON

PHR: NARRATIVE Genetic diseases such as dentinogenesis imperfecta, bacterial diseases such as dental caries or fractures represent common public health problems that affect a major part of the population worldwide and impose significant burdens on patients. As dentin regeneration remains elusive, the identification of molecular mechanisms controlling dentinogenesis is of immediate need. The goal of this project is to determine the mechanisms defining dental cell fate early in development and harness this information to develop potential therapeutics for dentin regeneration.

PI_NAMEs: BEI, MARIANNA  (contact)

PROGRAM_OFFICER_NAME: WANG, LU

PROJECT_TERMS: Affect;Bacterial Infections;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Differentiation process;Cell Line;Cell Proliferation;Cell Therapy;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Chromatin;Communicable Diseases;cost;Data;Dental;Dental caries;Dental Enamel;Dentin;Dentinogenesis;Dentinogenesis Imperfecta;Dentistry;Development;differentiation in vitro;Direct Costs;Embryo;Enhancers;Epithelium;Esthetics;Fracture;functional restoration;Future;Gene Expression Profile;General Population;Genes;Genetic;Genetic Diseases;genetic signature;Goals;healing;In Vitro;inhibitor;Injury;Knowledge;Lead;Mesenchymal;Mesenchymal Differentiation;Mesenchymal Stem Cells;Mesenchyme;Methods;Molecular;Molecular Profiling;MSX1 Transcription Factor;Multipotent Stem Cells;mutant;Mutant Strains Mice;Natural regeneration;Odontoblasts;Odontogenesis;Organ;Organogenesis;Pathway interactions;Patients;Play;Population;Prevalence;Process;Proliferating;protein protein interaction;Proteins;Public Health;regenerative;Repression;Research Design;Role;Series;single cell ATAC-seq;single-cell RNA sequencing;Snails;Source;stem cell differentiation;stem cell population;stem cell proliferation;stem cell therapy;stem cells;Sumoylation Pathway;Testing;Therapeutic;Tissues;Tooth Diseases;Tooth regeneration;Tooth structure;transcription factor;Work

PROJECT_TITLE: Molecular mechanisms controlling tooth development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-A (04)]