ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Nutrition

ORG_CITY: VALLEJO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TOURO UNIVERSITY OF CALIFORNIA

ORG_STATE: CA

PHR: High sugar consumption is associated with chronic diseases; among the sugars, fructose is the most detrimental, but we do not know why. The parent grant targets mechanisms by which fructose metabolism in the liver contributes to chronic diseases, while this proposal addresses non-hepatic metabolism of fructose, including 1) the amount of fat made in the gut and intestinal factors involved in regulating fat in the bloodstream, 2) how much fructose circulates in the bloodstream, and 3) how much fructose is used as fuel, thus producing CO2. This proposal is relevant to NIDDK's mission as conclusions reached by the ancillary and parent grants will contribute valuable mechanistic information to help lay the foundation for public health policies and strategies for preventing and treating chronic diseases.    parent grants will contribute valuable mechanistic information to help lay the foundation for public health policies and strategies for preventing and treating chronic diseases.

PI_NAMEs: JONES, GRACE MARIE (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acetates;Address;Affect;apolipoprotein C-III;Apolipoproteins;Apolipoproteins B;Apolipoproteins C;Apoproteins;Appearance;Beds;Biological Assay;Blood Circulation;Carbon Dioxide;Cardiovascular Diseases;cardiovascular disorder risk;Chronic Disease;Chylomicrons;Circulation;comparison control;Consumption;Data;Diet;dietary;Dose;Enrollment;Enzyme-Linked Immunosorbent Assay;Extrahepatic;Fatty acid glycerol esters;feeding;Foundations;Fructose;Gluconeogenesis;Glucose;Glycogen;Health Policy;Hepatic;hepatic gluconeogenesis;Human;Hyperlipidemia;Impairment;Indirect Calorimetry;Ingestion;Insulin Resistance;Intake;interest;Intestines;Intravenous;Intravenous infusion procedures;Isotopes;Label;Laboratories;lipid biosynthesis;Lipids;Lipoproteins;Liver;liver metabolism;Mass Fragmentography;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolism;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Oral Administration;oxidation;parent grant;Parents;Peripheral;Physiological;Plasma;Population;Prediabetes syndrome;prevent;Process;Production;Public Health;Publishing;Reporting;response;Risk;Role;Route;Site;Small Intestines;stable isotope;Stable Isotope Labeling;sugar;Techniques;Time;Tissues;Tracer;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Extra-hepatic postprandial metabolism of dietary fructose

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: New York

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

ORG_STATE: NY

PHR: Inflammatory factors in inflamed joints of RA patients activate cells called macrophages to produce molecules called cytokines that drive disease pathology. The goals of this project are to understand mechanisms that control the balance and extent of inflammatory cytokine production by RA synovial (joint) macrophages. We anticipate that our studies will provide knowledge that can be used to develop new therapies to suppress inflammation and joint damage in RA patients.

PI_NAMEs: IVASHKIV, LIONEL B (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Ablation;activating transcription factor;Antibody Response;Antigen-Antibody Complex;Apical;Arthritis;Attenuated;autocrine;B-Lymphocytes;Bacterial Artificial Chromosomes;cathelicidin antimicrobial peptide;Cell Death;Cell surface;Cells;chemokine;Chromatin;chromatin remodeling;cytokine;Cytokine Signaling;Dendritic Cells;Disease;DNA;Endocytosis;Endosomes;Epigenetic Process;epigenomics;Equilibrium;Exhibits;Extracellular Matrix Degradation;Feedback;Gene Activation;gene induction;Gene Silencing;Genes;Genetic Transcription;Goals;HMGB1 gene;Host Defense;Human;Hypoxia;IKKepsilon;IL6 gene;In Vitro;in vivo Model;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;inhibitor;insight;Interferon-beta;Interferons;Interleukin-10;Interleukin-6;joint inflammation;joint injury;Joints;Knowledge;Link;Macrophage;Mediating;Modeling;Molecular;monocyte;Mus;Myeloid Cells;NF-kappa B;novel;novel therapeutics;Nucleic Acid Binding;Nucleic Acids;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient subsets;Patients;Pattern;Peptides;Physiological;Play;Production;Regulation;Resolution;response;Rheumatoid Arthritis;RNA;selective expression;Seminal;sensor;Signal Pathway;Signal Transduction;STAT3 gene;synergism;Synovial Membrane;Synovitis;TBK1 gene;TCF Transcription Factor;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;TLR2 gene;TLR3 gene;TLR7 gene;TLR8 gene;TNF gene;Toll-like receptors;trafficking;transcription factor;Transcription Factor AP-1;Transgenic Mice;Work

PROJECT_TITLE: Cytokine Balance in Rheumatoid Arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases;Nanotechnology;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE HIV transmission can be effectively controlled if new infection and treatment failure can be detected early. Increasing access to routine HIV testing, especially self-testing that allows individuals at risk to know their HIV status timely and privately, can greatly improve HIV prevention in the United States. This project aims to develop an easy-to-use ultrasensitive HIV self-testing device to allow lay persons to perform quantitative HIV antigen measurement with finger prick blood.

PI_NAMEs: LIU, CHANG  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;acute infection;Adherence;Age;AIDS prevention;antibody detection;Antibody Response;antigen challenge;antigen detection;antigen test;Antigens;antiretroviral therapy;Belief;Benchmarking;Benefits and Risks;Biological Assay;Biological Markers;Blood;Blood Glucose;Blood specimen;CD4 Lymphocyte Count;Cellular Phone;Characteristics;Chemistry;Clinical;Clinical assessments;Clinical Markers;cost;cost effective;Detection;detection limit;detection sensitivity;Devices;Diagnostic;Drug resistance;Early Diagnosis;Early identification;Enrollment;Ensure;Enzyme-Linked Immunosorbent Assay;experience;Feedback;Fingers;Generations;Health;HIV;HIV Antigens;HIV Infections;HIV Seronegativity;HIV-1;HIV/AIDS;Home;Human immunodeficiency virus test;Immunology;improved;Incidence;Individual;Infection;innovation;Ions;isothermal amplification;Label;Laboratories;Learning;Longitudinal Studies;Measurement;Measures;Mediating;Methods;Microfluidic Microchips;Microfluidics;minimally invasive;Monitor;nanoparticle;nanopore;nanosized;Nucleic Acid Amplification Tests;Nucleic Acids;Participant;Patients;Pattern;Performance;performance tests;Persons;Phase;Polymerase Chain Reaction;Population;Preparation;prisma;Privatization;Process;Proteins;Proteomics;Protocols documentation;prototype;Reaction;Reader;recruit;Research;research and development;research clinical testing;Risk;RNA;Sampling;satisfaction;self testing;Sensitivity and Specificity;sex;Signal Transduction;Specificity;Specimen;Structure;Surveys;Technology;Testing;Therapeutic;therapy adherence;Time;transmission process;Treatment Efficacy;Treatment Failure;United States;usability;user friendly software;Validation;viral detection;Viral Load result;viral rebound;Whole Blood

PROJECT_TITLE: Nanopore-Based HIV Self-Test for Ultrasensitive p24 Quantification in FingerPrick Blood


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative  Heading perception is determined from visual and vestibular cues which must be integrated to determine self-motion within an environment. This is this proposal seeks to better understand these phenomena which are likely factors in dizziness and motion sickness.

PI_NAMEs: CRANE, BENJAMIN T (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acceleration;Acoustic Neuroma;Acute;Attention;Auditory;Brain Concussion;Calibration;Characteristics;Chronic;Clinical;clinical investigation;clinically significant;Complex;Cues;Data;Dementia;Disease;Dizziness;Environment;Etiology;Evaluation;Exhibits;experience;Exposure to;fall risk;Functional disorder;Future;Gentamicins;Hearing;Human;improved;Individual;Lesion;Longitudinal Studies;Measures;Meniere's Disease;Methods;Migraine;Motion;Motion Perception;Motion Sickness;Movement;multimodality;multisensory;novel;otoconia;Pathologic;Pathology;Patients;Perception;Physiological;Physiology;Population;Process;Proprioception;Reflex action;Rehabilitation therapy;Reporting;Reproducibility;research clinical testing;Rotation;segregation;Self Perception;Sensory;sensory stimulus;sensory system;Side;Stimulus;Symptoms;System;Techniques;Testing;Therapeutic;Time;tool;Translations;Vertigo;Vestibular function;Vestibular loss;vestibular reflex;vestibular system;virtual environment;virtual reality simulation;Vision;Visual;Visual Fields;Visual Motion;visual stimulus;Visual System;visual-vestibular;Work

PROJECT_TITLE: Multi-modal vestibular perception

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Brain atlases are essential in guiding studies on brain functions under normal and disease conditions. Currently available atlases and methods for building such atlases, even for simpler laboratory model organisms, are simplistic, not accurate, labor intensive to build and update, and difficult to use. This project will pioneer a technique to address the current challenges and may be generalizable to many other systems.

PI_NAMEs: LU, HANG  (contact);ZHANG, YUN

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TITLE: Modularly built, complete, coordinate- and template-free brain atlases

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Researchers are devoting increasing attention to the grave and varied health-focused implications of mass incarceration – especially since the onset of the covid-19 pandemic – but there is no comprehensive historical study of health care in U.S. carceral institutions. Minimal Standards of Adequacy: A History of Health Care in U.S. Prisons analyzes how policy makers, the courts, medical professionals, incarcerated people, and others defined and experienced prison health services during the past century. It will enrich understandings of U.S. medical, policy, and legal history, and be an asset to stakeholders aiming to think critically and productively about how to improve the health and well-being of people in and beyond prisons.

PI_NAMEs: ADLER, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Abuse Reporting;Advocate;American Medical Association;American Public Health Association;Archives;Articulation;Attention;Books;Caring;Chronic;Civil Rights;Collaborations;Communities;Complex;Conceptions;Constitution;Country;court;COVID-19;COVID-19 impact;COVID-19 pandemic;Critical Thinking;Data;Development;diaries;Ethics;expectation;experience;Face;Gambling;Government;Group Meetings;Health;health care availability;health disparity;Health Policy;Health Services;Healthcare;Healthcare Systems;Hepatitis C;HIV/AIDS;Hospitals;Imprisonment;improved;insight;Institution;Interdisciplinary Study;Jail;Justice;Legal;Length;Letters;Literature;marginalized population;Medical;Medical Research;Medicine;men;Mental disorders;Modernization;Movement;Nature;news;Peer Review;Penetration;Personal Satisfaction;Persons;Policies;Policy Maker;Population;Prisons;Privatization;Productivity;Professional Organizations;programs;Public Health;Published Comment;Publishing;Reader;Recording of previous events;Reporting;Research;Research Personnel;Research Subjects;Review Literature;Rights;Science;Service provision;Services;Sexually Transmitted Diseases;Shapes;social movement;Source;Statutes and Laws;Time;trend;Tuberculosis;United States;Variant;Woman;Work;World War II

PROJECT_TITLE: Minimal Standards of Adequacy: A History of Health Care in US Prisons


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARATIVE The main goal of this project is to determine the contribution of the ID/ASD-risk SETD5 gene during human development in healthy and disease conditions. We will determine the molecular downstream targets of SETD5, the contribution of the non-neuronal IL6 mediated neurotoxicity and test pharmacological and genetic therapeutic interventions.

PI_NAMEs: GOREN, ALON ;MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 2 year old;Acute;Address;Affect;Antisense Oligonucleotides;Appearance;Astrocytes;ATAC-seq;Attenuated;attenuation;autism spectrum disorder;autism symptoms;Automobile Driving;Behavior;Behavioral;Binding;Biochemical;Biological Assay;Brain;brain cell;brain dysfunction;Catalogs;Cells;Child;Child Development;ChIP-seq;Chromatin;chromatin remodeling;Clinical;Communication;Communication difficulty;Compensation;Complex;cost;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;debilitating symptom;Defect;design;Development;Diagnosis;Disease;disorder risk;Drug Screening;Early Intervention;effective therapy;Electrophysiology (science);Emotional;Epigenetic Process;Epilepsy;Ethnic Origin;Etiology;experience;Failure;Family;Financial Hardship;Functional disorder;Gene Targeting;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome editing;genomic tools;Genomics;global run on sequencing;Goals;Heterogeneity;Histones;Homeostasis;Human;Human Development;human induced pluripotent stem cells;IL6 gene;Impaired cognition;Impairment;improved;In Vitro;Individual;Induced Neurons;Intellectual functioning disability;Interpersonal Relations;Janus kinase;kinase inhibitor;Knowledge;Life;Link;loss of function;Lysine;Mediating;Methods;Methyltransferase;Modeling;Molecular;Motor;motor impairment;mouse model;multiple omics;Mus;Mutate;Mutation;NCOR1 gene;neural;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;neurotoxic;neurotoxicity;new therapeutic target;novel;Nuclear Pore Complex;Optics;Outcome;pancreatic differentiation 2 protein;Pathology;Pathway interactions;pharmacologic;Physiology;Play;prevent;Process;psychologic;Public Health;Race;Recovery;Regulator Genes;Research;risk variant;RNA Processing;Role;Sensory;service intervention;SET Domain;Severities;single-cell RNA sequencing;skills;social;socioeconomics;Stereotyping;Structure;synaptogenesis;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;trait;Transcription Elongation;Translations;United States;Visualization

PROJECT_TITLE: Novel SETD5-based Molecular Mechanisms and Therapeutic Tools to Understand and Revert Neuronal Dysfunction Associated with Intellectual disability and Autism


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Diseases such as cystic fibrosis, all forms of dementia, prion/scabies diseases, and diabetes result in dysfunctional proteins due to aberrant folding events involving lipid-protein interactions. Understanding the underlying principles governing lipid-dependent folding and assembly of proteins in cell membranes will provide information necessary to modulate the seriousness of genetic defects or pathophysiological states resulting from such aberrant protein folding.

PI_NAMEs: BOGDANOV, MIKHAIL V.;DOWHAN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Aerobic;Affect;Amino Acid Sequence;Amino Acids;Area;Behavior;Binding;Biochemical;Biological;cardiolipin synthase;Cardiolipins;Cell division;cell growth;Cell membrane;Cell Physiology;Cells;Charge;Chemicals;Cystic Fibrosis;Cytoplasm;Defect;Dementia;Diabetes Mellitus;Disease;driving force;Engineering;Environment;Enzymes;Equilibrium;Escherichia coli;Eubacterium;Event;experimental study;Genes;Genetic Complementation Test;Goals;Gram-Negative Bacteria;Growth;Hydrophobicity;In Vitro;in vivo;insight;Integral Membrane Protein;interfacial;Laboratories;Libraries;Lipid Bilayers;Lipids;Measures;Mechanics;Membrane;membrane assembly;Membrane Biology;Membrane Lipids;Membrane Proteins;membrane reconstitution;Membrane Structure and Function;method development;Methods;misfolded protein;Modeling;Molecular;Molecular Genetics;mutant;Mutation;new growth;novel;Organelles;Organism;Pathogenicity;Pattern;Peptides;Phenotype;Phosphatidylethanolamine;Phosphatidylglycerols;Phospholipids;Phosphorylation;Physiological;Play;Prions;Process;Protein Dephosphorylation;Protein Dynamics;Protein Engineering;protein function;protein misfolding;protein structure;Proteins;proteoliposomes;Reagent;response;Role;Scabies;scaffold;Septal Region;Signal Transduction;System;temperature sensitive mutant;Testing;Thermodynamics;Transmembrane Domain

PROJECT_TITLE: Dynamic Lipid and Protein Organization in Cell Membranes

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LEXINGTON

ORG_NAME: OASIS PHARMACEUTICALS

ORG_STATE: MA

PHR: The only FDA-approved treatment for thrombotic stroke is tissue plasminogen activator, but it is used in less than 5% of stroke victims with no noted improvement in survival and with no direct neuroprotective effects. Here, we provide a blueprint for developing the first GPR31 inhibitor as an effective antiplatelet therapy that provides secondary neuroprotective effects for mitigating against the acute neurologic sequela of stroke for a potentially more effective and safer alternative option or adjunct to fibrinolytic therapy in this area of high unmet medical need.

PI_NAMEs: KULIOPULOS, ATHAN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acceleration;Acute;acute stroke;Adult;Adverse effects;Alteplase;antagonist;Arachidonate 12-Lipoxygenase;Arachidonic Acids;Area;Biological Assay;Blood Platelets;Boston;Brain Edema;Canis familiaris;Cardiovascular system;Cause of Death;Cell Death;Cells;Central Nervous System;Cerebrovascular Disorders;Chemistry;clinical effect;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;commercialization;cost estimate;Coupled;Cytochrome P450;Data;design;Development;disability;disabled;Dose;drug development;efficacy evaluation;Enzyme Induction;Enzyme Inhibition;Enzymes;experimental study;Fatty Acids;FDA approved;first-in-human;Formulation;G-Protein-Coupled Receptors;Genetic;Glucose;Glutamates;Goals;GPR31 receptor;Grant;GTP-Binding Proteins;Hemorrhage;Hemostatic function;Hepatic;Hydroxyeicosatetraenoic Acids;Hypertension;Implant;improved;Individual;Infarction;Inflammation;Inflammatory;Infusion procedures;inhibitor;Intracranial Hemorrhages;Intravenous;Ischemic Stroke;Knockout Mice;Lipids;manufacture;Mediating;Medical;Medical center;meetings;Membrane;Metabolism;method development;Modeling;Molecular Target;mouse model;Mus;Mutation;Neurologic;Neurology;neuron loss;Neurons;neuroprotection;Orphan;oxidation;Oxidative Stress;Oxygen;Papio;Pathologic;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Pharmacology Study;Phase;phase 1 study;Phase I Clinical Trials;Phenocopy;Physiological;post stroke;pre-clinical;Primary Prevention;Production;Program Development;Prostate;protective effect;Rattus;receptor;Recovery;Reporting;respiratory;Risk Factors;Role;Safety;safety assessment;Series;side effect;Signal Transduction;Signaling Molecule;Small Business Technology Transfer Research;Specificity;Stroke;stroke model;stroke patient;stroke therapy;stroke victims;Symptoms;Technology;Telemetry;Therapeutic;Thrombolytic Therapy;Thrombosis;thrombotic;Thrombotic Stroke;Time;Tissue Model;Tissues;Toxic effect;Toxicology;Validation;Water

PROJECT_TITLE: Lipid Receptor GPR31 as a Target for Anti-Thrombotic and Stroke Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE In the United States, substance use behaviors contribute to the leading causes of mortality and morbidity of adolescents, and are associated with approximately $60 billion in economic costs per year. Influence from social peers can contribute to adaptive or maladaptive decision-making in adolescents and depends on the context and nature of the peers. Here, we combine a longitudinal cohort design, functional neuroimaging, novel behavioral economic paradigms, and a model-based approach to examine how social information influences decision processes leading adolescents to make risky or safe choices, including substance use behaviors.

PI_NAMEs: CASAS, BROOKS  (contact);CHIU, PEARL H

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Addictive Behavior;Adolescence;Adolescent;Adolescent Development;adolescent substance use;Affect;Age;Anterior;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral economics;Behavioral Mechanisms;Computer Models;Data;Decision Making;design;Development;drug seeking behavior;early onset substance use;economic cost;Economic Models;Environmental Risk Factor;Evaluation;Female Adolescents;Functional Magnetic Resonance Imaging;Health;Humulus;Individual;Individual Differences;information processing;Insula of Reil;Intervention;Investigation;Longitudinal cohort;Male Adolescents;Measures;Modeling;Morbidity - disease rate;mortality;Nature;neural;neurobehavioral;neuroimaging;neuromechanism;neurotoxic;novel;Outcome;Participant;Pattern;peer;peer influence;Predisposition;Prefrontal Cortex;Probability;Process;recruit;resilience;response;Risk Behaviors;Risk Factors;Scanning;social;social cognition;social influence;social observations;Social support;Social Values;substance use;Testing;Time;United States;Update

PROJECT_TITLE: Social influences on choices in adolescent substance use

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa use a cell-cell communication process called quorum sensing to orchestrate collective behaviors required for virulence and biofilm formation. QS relies on the group-wide detection of extracellular signal molecules called autoinducers. These studies will provide insight into the role played by two newly discovered regulators that control the response of activated quorum-sensing receptors, potentially providing key information for the development of new medicines to combat bacterial pathogens.

PI_NAMEs: PACZKOWSKI, JON E (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Affect;Affinity;Anti-Bacterial Agents;Architecture;Bacteria;Behavior;Binding;Biochemical;Biological Assay;Carrier Proteins;Cell Communication;Cell Cycle;Cell Density;Cell Signaling Process;Cells;ChIP-seq;Clinical;combat;Communication;Communities;Complex;cost;Data;Deoxyribonucleases;Detection;Development;DNA;DNA Binding;DNA Binding Domain;Down-Regulation;Environment;Enzymes;experimental study;extracellular;Gene Expression;Gene Expression Profile;Genes;genetic approach;Genetic Transcription;Goals;Growth;High-Throughput Nucleotide Sequencing;human pathogen;In Vitro;in vivo;Infection;insight;Ligands;Light;Maps;Mediating;Medicine;metalloenzyme;Microbial Biofilms;microbial community;Molecular;Molecular Conformation;Mutagenesis;Mutation;novel;Organism;Output;Pathogenesis;pathogenic bacteria;Phase;Play;prevent;Process;Production;promoter;protein folding;protein protein interaction;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;quorum sensing;receptor;receptor binding;Regulation;Regulatory Element;Regulon;Relaxation;Reporter;Repression;response;rhamnolipid;Role;Shapes;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Specificity;Structure;surfactant;System;Techniques;Therapeutic;Time;trait;transcription factor;Transcriptional Regulation;transcriptome sequencing;transmission process;Up-Regulation;Virulence;Virulence Factors;X-Ray Crystallography

PROJECT_TITLE: Characterization of the mechanisms underpinning quorum sensing progression in Pseudomonas aeruginosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(02)M]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Narrative Using a model system of ERα in breast cancer, we will a) identify distinct types of ERα-regulated chromatin interacting foci including promoter-enhancer, enhancer-enhancer and enhancer-repressor looping foci; and b) identify 3D-regulated breast cancer cell identities and sensitive-resistant transition cell subpopulations. The successful completion of our project may result in the better understanding of the contribution of enhancer- enhancer interacting network towards to functions of various biological processes, in particular breast cancer endocrine resistance, and on how 3D chromatin structure governs the breast cancer sensitive cell subpopulations into resistant cell subpopulations.

PI_NAMEs: JIN, VICTOR  (contact);LIN, SHILI

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 3-Dimensional;Apoptosis;Architecture;Awareness;Bayesian Method;Binding;Biological Assay;Biological Models;Biological Process;Breast Cancer Cell;cancer cell;Cell Line;Cell model;Cell Nucleus;Cell Proliferation;cell transformation;cell type;Cells;Characteristics;Chromatin;Chromatin Loop;Chromatin Structure;Chromosome Territory;Classification;Communities;Complex;Computer Analysis;Computer Models;Computing Methodologies;CRISPR/Cas technology;Data;Data Set;Dropout;Endocrine;Enhancers;EP300 gene;Epigenetic Process;ESR1 gene;Estrogens;experimental study;Funding;gain of function;Gene Expression Regulation;Genes;genomic profiling;Genomics;Goals;Graph;HDAC3 gene;Hi-C;Higher Order Chromatin Structure;Hormones;Human Genome;Invaded;KDM1A gene;Malignant Breast Neoplasm;malignant endocrine gland neoplasm;Malignant Neoplasms;MCF7 cell;Measures;Metabolism;Methods;Modeling;Modification;Names;novel;Outcome Measure;Phenotype;Play;preservation;prognostic signature;promoter;Resistance;Signal Pathway;Statistical Methods;Stimulus;T47D;Tamoxifen;Technology;Testing;Three-dimensional analysis;Time;Transcriptional Regulation

PROJECT_TITLE: Omics analysis of three-dimensional transcriptional regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Cognitive impairment and dementia is a major source of disability in Parkinson disease and Dementia with Lewy bodies, yet how these symptoms develop and progress is not well understood. The objective of this proposal is to understand the role of the pathological protein alpha-synuclein in causing the dysfunction of cortical circuits that leads to cognitive impairments, as well as how changing the activity of circuits might impact the advancement of Parkinson disease associated pathology. This knowledge will be essential for designing clinical trials to treat symptoms of cognitive impairment, or even slow the progression of these diseases.

PI_NAMEs: ZEIGER, WILLIAM ABEL (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Anatomy;area striata;Autopsy;behavioral study;beta amyloid pathology;Biological Models;Biology;Brain;Calcium;Caregivers;Cells;Cessation of life;Chronic;Clinical Trials Design;Corpus striatum structure;cost;Dementia;Dementia with Lewy Bodies;Denervation;Deposition;designer receptors exclusively activated by designer drugs;Development;Diagnosis;disability;Disease;Disease Progression;Exhibits;experimental study;Functional disorder;Functional impairment;Future;Genetic;Hallucinations;Human Pathology;Image;imaging modality;imaging system;Impaired cognition;Impairment;in vivo;in vivo imaging;Individual;innovation;Knowledge;Label;Lead;Lewy Bodies;Lewy body pathology;Lewy neurites;Link;Mediating;mild cognitive impairment;Modeling;Monitor;Motor Cortex;motor symptom;mouse model;Mus;Neocortex;neural;neural circuit;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;neuroregulation;novel;Parkinson Disease;Pathologic;Pathology;Patients;Pattern;Population;postsynaptic;pre-formed fibril;presynaptic;prevent;Process;Proteins;Recombinants;Research;Resolution;Rodent;Role;serial imaging;Site;Societies;Source;symptom treatment;Symptoms;synucleinopathy;System;Testing;Therapeutic Uses;Time;tool;Transgenic Mice;translational study;transmission process;two-photon;Viral;Visualization

PROJECT_TITLE: Reciprocal interactions between cortical circuit dysfunction and α-synuclein pathology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: Sepsis remains to be associated with a significant morbidity and mortality, and the development of a novel therapy is urgently needed. Neutrophils are the first-line defense leukocytes for microbial eradication, and the de novo generation of mature neutrophils with high effector functions are needed, but immature neutrophils are also released into the circulation to match a demand for neutrophil number. In this proposal, we will examine our hypothesis that CD11c would be a critical regulator of neutrophil maturation and effector functions and will also screen CD11c small molecule agonists and antagonists.

PI_NAMEs: YUKI, KOICHI  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accounting;Adult;Advocate;aged;Aging;Agonist;antagonist;antimicrobial;Binding;Biological Assay;Biological Markers;Blood;Bone Marrow;candidate identification;CD34 gene;cecal ligation puncture;Cell Adhesion Molecules;Cell surface;Cells;Child;Circulation;Clinical Trials;Complement Receptor;cost;CRISPR/Cas technology;cytokine;Data;Dendritic Cells;Development;Emergency Situation;Escherichia coli;experimental study;Future;Generations;Genes;Genetic Transcription;Goals;Granulocyte Colony-Stimulating Factor;Granulopoiesis;Hematopoietic stem cells;Heterogeneity;HL-60 Cells;Hospital Mortality;Hospitalization;Host Defense;Human;Immune;improved;improved outcome;In Vitro;in vivo;Incidence;Infection;Integrin Binding;Integrins;Intervention;ITGAX gene;ITGB2 gene;Knock-in Mouse;Knockout Mice;Leukocytes;Ligand Binding;Ligands;member;Microbe;microbial;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;novel;novel therapeutics;Ontology;Operative Surgical Procedures;Outcome;Output;Patients;peripheral blood;Phagocytes;Play;polymicrobial sepsis;Population;precursor cell;Production;Proliferating;Reporting;Research;Role;Sampling;Sepsis;septic;septic patients;Signal Pathway;single-cell RNA sequencing;small molecule;Sterility;Supportive care;Systemic Inflammatory Response Syndrome;Testing;Therapeutic;Therapeutic Intervention;Time;transcriptomic profiling;Translations;United States;Wild Type Mouse

PROJECT_TITLE: CD11c as a novel target to improve neutrophil effector functions and sepsis outcome

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The goal of this proposal is to define the molecular mechanisms that underlie the metabolic actions of insulin on skeletal muscle with the goal of elucidating new signaling mechanisms that contribute to metabolic disease. Specifically, this project will examine the role of AKT, a serine/threonine kinase, in the regulation of glucose metabolism and skeletal muscle growth by insulin.

PI_NAMEs: TITCHENELL, PAUL MICHAEL (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;adenylate kinase;Affect;Aging;AKT inhibition;Anabolism;Automobile Driving;Biochemical;blood glucose regulation;carbohydrate metabolism;Carbohydrates;Cardiovascular Diseases;Cardiovascular system;Clinical;Data;Defect;Development;Diabetes Mellitus;diabetic;Disease;Disuse Atrophy;Effectiveness;Event;Exhibits;experimental study;FOXO1A gene;Functional disorder;Genetic;genetic manipulation;Glucose;glucose disposal;Glucose Intolerance;glucose metabolism;glucose uptake;Goals;Growth;Homeostasis;Hormones;Human;Hyperglycemia;improved;in vivo;Individual;Insulin;insulin mediators;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;interest;Investigation;Isotope Labeling;Knowledge;Measures;Mediating;Medical;Metabolic;Metabolic Control;Metabolic Diseases;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;molecular modeling;Molecular Target;Mus;Muscle;muscle form;Muscle function;Muscle Mitochondria;Muscle Proteins;Muscular Atrophy;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Organ;Pathway interactions;Performance;pharmacologic;phosphoproteomics;Phosphotransferases;Pilot Projects;Play;preservation;Protein Biosynthesis;protein degradation;protein metabolism;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;Regulation;Research;restoration;Role;Serine;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle growth;skeletal muscle metabolism;skeletal muscle wasting;stem;Techniques;Testing;Therapeutic Intervention;Time;Treatment Efficacy;uptake;wasting

PROJECT_TITLE: Regulation of Skeletal Muscle Metabolism by Insulin Signaling

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The voltage-gated proton channel Hv1 plays roles in proton extrusion, pH homeostasis, and production of reactive oxygen species in a variety of cell types. There is a need for discovery of Hv1 regulators that confer important physiological profiles required for the function of cells where the Hv1 channels expressed. We identified new Hv1 channel regulators and will determine the roles of their function in regulation of Hv1 proton channel.

PI_NAMEs: HONG, LIANG  (contact)

PROJECT_TERMS: Acids;Action Potentials;Adaptive Immune System;Affinity;airway surface liquid;Alveolar Cell;Binding;Binding Sites;Biochemical;Biophysical Process;biophysical properties;Biophysics;Cell membrane;Cell Physiology;cell type;Cells;channel blockers;Charge;Co-Immunoprecipitations;Compensation;Complex;design;Disease;Dissociation;drug development;Elements;Epithelial Cells;Family;Goals;in vivo;insight;Integral Membrane Protein;Interferons;Ion Channel Gating;Kinetics;knock-down;Lung;Mediating;member;Membrane;Molecular;Mutagenesis;mutant;Mutation Analysis;NADPH Oxidase;Neurons;neutrophil;novel;paralogous gene;Permeability;pH gradient;pH Homeostasis;Phagocytes;Pharmacology;Physiological;Physiology;Play;Production;Proteins;Protons;Reactive Oxygen Species;Regulation;Research;Respiratory Burst;RNA Interference;Role;Scanning;screening;Shapes;Site;Snails;Sperm Capacitation;sperm cell;Testing;therapy development;Tissues;voltage;yeast two hybrid system;Yeasts

PROJECT_TITLE: Regulation of Voltage-gated Proton Channel


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The function of S1P-signaling in AD is more complex than assumed and demands further investigation. Our research will test a novel hypothesis that the S1P transporter Spns2 contributes to AD pathogenesis by promoting microglial pro-inflammatory activation induced by AD-related stimuli. By focusing on Spns2, this proposal holds a unique premise to reveal novel aspects of S1P-signaling in AD

PI_NAMEs: BIEBERICH, ERHARD  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;amyloid pathology;antagonist;Anti-Inflammatory Agents;Astrocytes;astrogliosis;ATP binding cassette transporter 1;Autopsy;Brain;cell type;Central Nervous System;Ceramides;Chronic;Clinical;cognitive function;Complex;Data;Disease;Drug Kinetics;Exposure to;extracellular;Extracellular Space;genome wide association study;glial activation;Goals;Homologous Gene;Immune;Impaired cognition;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Inorganic Phosphate Transporter;Investigation;Knockout Mice;Lipids;MAPT gene;Mediating;Microglia;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuroprotection;NF-kappa B;novel;novel therapeutic intervention;Onset of illness;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathology;Pathway interactions;Peptides;Phagocytosis;Phagocytosis Induction;Phenotype;Play;pre-clinical;Procedures;Process;Proteins;Public Health;Regulation;Reporting;Repression;Research;response;Role;Senile Plaques;Signal Induction;Signal Pathway;Signal Transduction;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;Stimulus;tau Proteins;Testing;Therapeutic

PROJECT_TITLE: Regulation of Microglial Activation State by a Lipid Transporter

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative We will develop a novel chemical scaffold that is effective in targeting the important and undertreated pathogen, Acinetobacteri baumannii. These and other compounds discovered in this project will be applied to unmet needs in antimicrobial resistance and undertreated bacterial pathogens.

PI_NAMEs: SCHMIDT, ERIC W (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Animals;Anti-Bacterial Agents;Antibiotics;Antimicrobial Resistance;Bacteria;Benign;Biological Assay;Biology;Cecum;Cells;Cellulases;Cellulose;chemical genetics;chemical synthesis;Chemicals;Chemistry;Clinical;clinically relevant;combat;Communicable Diseases;Consumption;Data;design;Digestion;Distant;Distel;drug development;drug discovery;Drug resistance;Eating;Ecology;Environment;Evolution;experience;experimental study;gene cloning;Genetic;genetic analysis;Genetic Engineering;Genomics;Gills;Glucose;Goals;guided inquiry;Health;Human;human pathogen;improved;in vivo;interest;Investments;Learning;Marketing;Membrane;Methods;Microbe;microbial;Modification;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Natural Product Drug;Natural Products;new technology;novel;novel therapeutics;Nutritional;pathogen;pathogenic bacteria;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Physiology;Process;Production;programs;Property;Research;Resistance;resistant strain;Role;scaffold;Science;Sea;Series;small molecule;Source;Streptomyces;symbiont;Symbiosis;System;Technology;Time;Toxic effect;virtual;Volatile Fatty Acids;Water;Wood material

PROJECT_TITLE: Microbial Ecology-Guided Discovery of Antibacterial Drugs

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Single-particle cryo-EM, a method of molecular structure research pioneered in the PI's lab, has been further developed with the inclusion of time-resolved techniques to allow capture and structure determination of short- lived states. A combination of standard and time-resolved techniques will be applied to elucidate processes in protein biosynthesis with fundamental significance to public health. In addition, a novel method of data analysis aiming at characterization of the dynamic behavior of molecules will be applied to large datasets of important membrane-associated molecules: rotary ATPase and Cystic fibrosis trans-membrane conductance regulator.

PI_NAMEs: FRANK, JOACHIM  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: ATP phosphohydrolase;Behavior;Biological;Collaborations;Cryoelectron Microscopy;Cystic Fibrosis Transmembrane Conductance Regulator;Data Analyses;Dimensions;Encephalomyocarditis virus;Escherichia coli;Free Energy;Image;Kinetics;large datasets;Length;Liquid substance;macromolecular assembly;macromolecule;Maps;Membrane;Methods;Microfluidic Microchips;millisecond;Molecular Conformation;Molecular Structure;novel;particle;Preparation;Procedures;Process;Protein Biosynthesis;Public Health;Quality Control;Reaction;Recycling;Research;Resolution;Ribosomes;Sampling;Specialist;Structure;Techniques;Time;Translation Initiation;Translation Process;Translational Regulation;Translations;Virus;Visualization;Yeasts

PROJECT_TITLE: Structural Studies of Macromolecular Assemblies Using Cryo-EM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Emergency Care;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DAVIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The primary objective of the Northern California Acute Care Research Consortium (NORCARES) Hub is to facilitate the enrollment of a diverse population of patients into SIREN clinical trials. The highly adaptable design of NORCARES includes an innovative Co-Hub and multi-PI model, allowing for flexibility to maximize patient enrollment regardless of the study focus. In this project, we seek to be leaders in SIREN and train junior investigators for future leadership roles in multicenter emergency care clinical trials.

PI_NAMEs: HIRSCH, KAREN G;NISHIJIMA, DANIEL KIDEN (contact);RODRIGUEZ, ROBERT

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Admission activity;Ancillary Study;Applied Research;Area;Asian;Black race;California;Cardiac;career;Clinical;clinical trial participant;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Hospitals;Critical Care;Data Coordinating Center;data hub;demographics;design;Development;dissemination strategy;diversity and equity;Education;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Emergency research;Emergency Situation;Enrollment;Ensure;ethnic diversity;Ethnic Origin;Event;experience;Faculty;Fellowship;flexibility;Fostering;Funding;Future;Gender;Generations;Geography;Goals;Good Clinical Practice;Grant;Growth;Growth and Development function;Health;Hematology;Heterogeneity;Hispanic;Hospitals;Human Resources;improved;improved outcome;Infrastructure;injured;innovation;Institution;Interdisciplinary Study;Leadership;Medical emergency;medical schools;medical specialties;Medicine;meetings;Mentors;Mentorship;Mission;Modeling;Multi-Institutional Clinical Trial;Multicenter Trials;Native Hawaiian or Other Pacific Islander;Neurologic;novel;participant enrollment;Patient Care;patient population;Patient-Focused Outcomes;Patients;pediatric emergency;Personal Satisfaction;Persons;Play;Population;Population Heterogeneity;Positioning Attribute;Productivity;programs;Quality Control;Race;racial diversity;Records;Regulation;Research;Research Activity;Research Infrastructure;Research Personnel;Research Proposals;Research Subjects;Resources;respiratory;Role;Rural;rural setting;San Francisco;Site;Site Visit;Solid;Special Population;Structure;symposium;System;Teacher Professional Development;Training;Training Programs;Trauma;trauma centers;Underrepresented Minority;United States National Institutes of Health;Universities;Woman


NIH_SPENDING_CATS: Clinical Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Bronchopulmonary dysplasia (BPD) is the severe lung disease that occurs in 10% of all preterm births. BPD results from a disruption in pulmonary vascular and alveolar growth. Our lab has been one of the first to demonstrate that vitamin D has striking pro- angiogenic effects in the distal vasculature of the developing lung. This current proposal will utilize animal models of BPD and vitamin D deficiency to study how vitamin D regulates vascular development in the fetal lung and how antenatal stress, especially in the setting of preterm birth, alters vitamin D signaling and contributes to the pathogenesis of BPD. This will help will lead to therapies that improve quality of life for infants with this severe lung disease.

PI_NAMEs: MANDELL, ERICA WYNNE (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Address;Adult;Adverse effects;Alveolar;angiogenesis;Animal Model;antenatal;Antiinflammatory Effect;Award;Bioinformatics;Biology;Blood Vessels;Board Certification;Bronchopulmonary Dysplasia;career;cell growth;Cell Proliferation;Chronic lung disease;Clinical;Clinical Research;Colorado;Data;Development;Developmental Biology;Distal;Endothelial Cells;Endothelium;Endotoxins;Environment;epidemiologic data;Epithelium;experience;Experimental Models;Exposure to;fetal;Fetal Lung;Funding;Genetic;genetic approach;Genomic approach;Genomics;Goals;Growth;high risk;Hyperoxia;Impairment;improved;Infant;Injury;insight;intraamniotic infection;Knockout Mice;Link;Literature;Lung;lung development;Lung Diseases;lung injury;Mediating;medical schools;Mentors;Mentorship;Metabolism;Modeling;mouse genetics;multidisciplinary;Neonatal Mortality;novel;Pathogenesis;Pathway interactions;Pattern;pediatric department;Perinatal;perinatal injury;Peroxisome Proliferator-Activated Receptors;Physicians;Play;postnatal;preclinical study;Predisposition;Premature Birth;Premature Infant;preservation;prevent;professor;protective effect;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Hypertension;Quality of life;Rattus;receptor expression;Regulation;Research;Research Personnel;respiratory;respiratory smooth muscle;Risk;Role;Scientist;Severities;Signal Pathway;Signal Transduction;skills;Smooth Muscle Myocytes;statistics;Stress;Structure;Therapeutic;Translating;Universities;vascular abnormality;Vascular Endothelial Growth Factors;Vitamin D;Vitamin D Deficiency;Vitamin D3 Receptor;Work

PROJECT_TITLE: Role of Vitamin D in Lung Development and Bronchopulmonary Dysplasia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Type 1 diabetes (T1D) accounts for ~5% of diabetes (20 million patients worldwide), and T1D patients are predicted to triple by 2050. There is no cure for T1D or means to determine the onset and progression of the disease. These proposed studies will elucidate key mechanisms underlying the development of T1D for the future development of novel therapeutics to prevent, delay the onset, and reduce progression of the disease.

PI_NAMEs: CHALFANT, CHARLES E. (contact);EIZIRIK, DECIO LAKS;RAMANADHAM, SASANKA

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: 5' Splice Site;Ablation;Alternative Splicing;Amendment;antagonist;Anti-sense RNA;Apoptosis;Apoptotic;Arachidonic Acids;autoimmune pathogenesis;bcl-xlong protein;BCL2 gene;Beta Cell;Biological Assay;Biometry;CASP9 gene;Cell Death;Cell Survival;cell type;Cells;Cellular Stress;Cessation of life;cytokine;Development;Diabetes Mellitus;Disease Progression;Eicosanoids;Elements;endoplasmic reticulum stress;Enzymes;Event;Evolution;Family member;Female;Fingerprint;Future;Generations;Genetic;Human;human induced pluripotent stem cells;Hydrolysis;Hydroxyeicosatetraenoic Acids;Hyperglycemia;improved;Inbred NOD Mice;Incidence;Inflammatory;inhibitor;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;islet;Knockout Mice;Link;lipidome;Lipids;liquid chromatography mass spectrometry;Macrophage;MCL1 gene;Mediating;Membrane;Modeling;Molecular;mRNA Precursor;novel;novel strategies;novel therapeutics;Oligonucleotides;Participant;Patients;Phospholipase;Phospholipids;Play;Prediabetes syndrome;preservation;prevent;Process;Protein Isoforms;Proteomics;receptor;Reporting;response;RNA;RNA Binding;RNA Splicing;Rodent;Rodent Model;Role;small hairpin RNA;Small Interfering RNA;Stimulus;Testing;Text;transcriptome sequencing;Variant

PROJECT_TITLE: iPLA2beta-mediated alternative splicing and beta-cell death in type 1 diabetes

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Physical Activity;Prevention

PHR: Project Narrative Affirmative findings from this randomized trial would demonstrate that a readily adoptable workplace intervention focused only on reducing sitting time alone, reduces cardiometabolic risk, particularly as it relates to risk of diabetes. Findings would provide insight to possible mechanisms by which sitting mediates disease.

PI_NAMEs: KULINSKI, JACQUELYN P (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Adopted;Adult;American Heart Association;arm;Bed rest;Biological;Blood Vessels;Body mass index;Body Weight;brachial artery;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Categories;Cellular Phone;Chronic Disease;clinical efficacy;Coronary heart disease;coronary plaque;COVID-19 pandemic;Data;Data Reporting;Dependence;design;Diabetes Mellitus;diabetes risk;diabetic;Disease;disorder risk;Dose;Endothelium;Energy Metabolism;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Etiology;Event;Exclusion;Exercise;Expenditure;Future;Goals;Grant;Growth;Guidelines;Health;Health Expenditures;Home;Hour;Human;Hydrolysis;Hypertriglyceridemia;Impairment;improved;in vivo;Incidence;insight;Insulin Resistance;insulin sensitivity;interest;Intervention;Intervention Studies;Knowledge;Link;Lipoproteins;Measurement;Measures;Mediating;Mendelian randomization;Meta-Analysis;Metabolic;Metabolic syndrome;Monitor;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;obese person;Obesity;Occupational;Occupations;Overweight;Persons;Physical activity;physical inactivity;Pilot Projects;Prediabetes syndrome;primary outcome;public health intervention;Randomized;Randomized Controlled Clinical Trials;randomized trial;Randomized, Controlled Trials;Recommendation;Research;resilience;response;Risk;Risk Factors;Risk Reduction;sedentary;sedentary lifestyle;Superficial Femoral Artery;Therapeutic;Time;Treatment Efficacy;trend;Triglyceride Metabolism;Triglycerides;Vascular Endothelium;Weight;Work;Workplace

PROJECT_TITLE: Stand Up for Your Health: A Randomized Study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because understanding the factors associated with outcomes along the hepatitis C care continuum and systematic evaluation of interventions to improve these outcomes, with particular attention to the complication of HIV coinfection, are essential for designing hepatitis C elimination strategies among people who inject drugs. While some empirical studies have evaluated efficacy or effectiveness of interventions to improve the hepatitis C care continuum, understanding the population level impact, cost-effectiveness, and generalizability of these interventions remains an important need for evidence- based policymaking. Thus, this proposal is relevant to NIH and NIDA’s mission of acquiring and applying new knowledge to improve health, lengthen life, and reduce illness and disability.

PI_NAMEs: ZHU, LIN  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Affect;Anti-viral Therapy;Attention;Award;Bayesian Method;Calibration;career;Caring;Characteristics;co-infection;Collaborations;collaborative environment;Communicable Diseases;Communication;Complex;Complication;Continuity of Patient Care;cost effective;cost effectiveness;design;disability;disorder control;Economics;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;Environment;Evaluation;evidence base;Foundations;Goals;Health;health economics;Health Policy;Hepatitis C;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C virus;Heterogeneity;HIV;HIV Infections;HIV/HCV;improved;improved outcome;Individual;Infection;Infrastructure;Injecting drug user;Injections;Intervention;Knowledge;Leadership;Life;Mathematics;medical schools;Meta-Analysis;Mission;Modeling;models and simulation;Morbidity - disease rate;National Institute of Drug Abuse;Needle-Exchange Programs;network models;Network-based;novel;Outcome;Pathway interactions;Policy Making;Population;Prognosis;Public Health;Research;Research Personnel;Research Training;Risk;Route;rural area;Services;Sex Behavior;skill acquisition;skills;social;social determinants;social vulnerability;societal costs;Structure;systematic review;Testing;therapy design;Time;Training;transmission process;Treatment Efficacy;Treatment outcome;Trust;United States National Institutes of Health;uptake;urban area;Variant;Viral;virus testing;Work

PROJECT_TITLE: Prospects for hepatitis C elimination in networks of people who inject drugs through improvements in the care continuum


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Endosomal pathway dysfunction is a well-accepted feature in Alzheimer’s disease cellular pathophysiology. Lacking and urgently needed are biomarkers of this pathway that can detect endosomal dysfunction in living patients and potentially accelerate drug discovery. The proposed study is designed to develop such biomarkers, using a mouse model of SORL1 dysfunction, mouse and human neuronal cultures, as well as human biofluids.

PI_NAMEs: ALVES SIMOES SPASSOV, SABRINA  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;APLP1 gene;beta secretase;beta-site APP cleaving enzyme 1;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;Brain;Cell Adhesion Molecules;Cells;Cellular biology;Cerebrospinal Fluid;Cognitive;Confocal Microscopy;Consensus;Core Protein;Cytopathology;Data;de novo mutation;Defect;design;Development;Diagnostic;Disease;Disease Progression;drug discovery;Electron Microscopy;Endosomes;Enzyme-Linked Immunosorbent Assay;exosome;Extracellular Space;Frontotemporal Dementia;Functional disorder;Genes;Genetic;genetic risk factor;Goals;Histopathology;Human;human pluripotent stem cell;Image;Knock-out;Knockout Mice;Lewy Body Disease;Link;Liquid Chromatography;Measures;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;Parkinson Disease;Participant;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Plasma;potential biomarker;Preparation;prodromal Alzheimer's disease;protein expression;Proteins;Proteomics;rare variant;receptor;Sampling;Senile Plaques;Source;specific biomarkers;Specificity;tandem mass spectrometry;tau Proteins;Technology;Testing;Therapeutic Intervention;trafficking;Transgenic Mice;Western Blotting

PROJECT_TITLE: Targeting Endosomal dysfunction as a new source of biomarkers for Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Neonatal infections are a global health concern, and are due to defects in the neonatal immune system’s ability to respond to and clear pathogens. We have experimentally modeled fetal, neonatal and infant immune system development under normal and inflammatory conditions to uncover important mechanisms controlling the maturation of immune responses in these settings. The success of the studies outlined in this proposal may lead to the identification of therapeutic targets that can improve survival and long-term outcomes related to neonatal inflammatory exposures.

PI_NAMEs: BERMICK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adaptive Immune System;Adult;Advanced Development;Affect;amnion;Asthma;ATAC-seq;Birth;Bone Marrow;Cells;Cessation of life;Chemotaxis;Child;ChIP-seq;Chorion;Chromatin;Chromatin Structure;Chronic;cytokine;Defect;Deposition;Development;Disease;early childhood;early life exposure;Environment;Exhibits;Experimental Models;experimental study;Exposure to;extreme prematurity;fetal;fighting;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic Code;Genetic Transcription;Germ-Free;global health;Health;high risk;histone modification;Histones;Homeostasis;Human;IFNAR1 gene;Immune;Immune response;Immune system;Immune System Diseases;Immunologics;immunoregulation;improved;in utero;infancy;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Interferons;Intestines;intraamniotic infection;intrauterine environment;Lysine;Macrophage;Mediating;Methylation;Methyltransferase;Microbe;microbial;microbial colonization;Mixed-Lineage Leukemia;MLL gene;Modeling;monocyte;mouse model;Mus;Myelogenous;Neonatal;neonatal immune system;neonatal infection;Neonatal Mortality;neonatal period;neonatal sepsis;neonate;offspring;Outcome;pathogen;Pattern;Perinatal;Phenotype;Placenta;postnatal;Predisposition;Premature Birth;preterm newborn;prevent;Process;promoter;response;Role;Signal Transduction;Site;Skin colonization;Sterility;success;Systems Development;Techniques;therapeutic target;Time;transcriptome sequencing

PROJECT_TITLE: Understanding the role of histone3 lysine4 trimethylation in neontal innate immune development under normal and inflammatory conditions

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Hematology;Infectious Diseases;Pediatric;Sepsis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE One in four children with septic shock die despite receiving intensive care and antibiotics, and cardiac dysfunction seems to contribute to this high mortality rate. No treatments exist for cardiac dysfunction in sepsis, and our goal is to better understand the causes of cardiac injury in children with septic shock to facilitate development of new medications to help these children recover and survive. We will study these processes using human cardiac cells and human serum, rather than animal models, to improve the ability to translate discoveries back to the bedside to improve patient care.

PI_NAMEs: LAUTZ, ANDREW JOHN (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Adult;Animal Model;Antibiotics;Back;biobank;Biological;Biology;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;career development;Cell Death;Cells;Child;Childhood Injury;Collection;CRISPR/Cas technology;CXCR;Data;Death Rate;Depressed mood;Development;Disease;Echocardiography;Excision;experimental study;exposed human population;Exposure to;Failure;Foundations;Functional disorder;Future;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Goals;Grant;Heart Injuries;Human;human induced pluripotent stem cells;human model;IL8RA gene;IL8RB gene;immunoregulation;improved;improved outcome;induced pluripotent stem cell derived cardiomyocytes;Intensive Care;Interleukin 8A Receptor;Interleukin-8;Knock-out;Laboratories;Mediating;Mitochondria;Modeling;Molecular;mortality;mouse model;Mus;Myocardial Depressant Factor;Myocardial dysfunction;neutralizing antibody;next generation;novel;Operative Surgical Procedures;organ injury;Pathogenesis;Pathway interactions;Patient Care;Patients;Pattern;pediatric patients;pediatric sepsis;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Physicians;Play;Predisposition;Process;programs;prospective;Recombinants;Research;response;Role;Scientist;Sepsis;septic;Septic Shock;Serum;Severity of illness;Signal Transduction;Technology;therapeutic target;Tissue Sample;Tissues;Training;transcriptome sequencing;Translating;translational model;Translational Research;Whole Blood

PROJECT_TITLE: Mechanisms of cardiomyocyte dysfunction in pediatric septic shock


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE One of the most debilitating side effects of cancer chemotherapy is cognitive impairment, including problems with attention, learning & memory, and executive functions. We have found that this condition is particularly prevalent in individuals who have inherited APOE4, which is also the strongest genetic risk factor for Alzheimer’s disease. The experiments here use a novel mouse model of chemotherapy-treated APOE4 mice to identify the molecular mechanisms behind this combined effect of APOE4 and chemotherapy, and to test whether there are preventative treatments to reduce this condition in those undergoing treatment for cancer.

PI_NAMEs: REBECK, G WILLIAM (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Acute;Adverse effects;Affect;Aging;aging process;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;antagonist;Anti-Inflammatory Agents;Antineoplastic Agents;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Attention;Autopsy;Behavior;Behavior assessment;behavioral impairment;Bexarotene;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;cancer therapy;Cell Physiology;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Research;Cognitive;cognitive process;cohort;Combination Drug Therapy;Controlled Study;Cyclophosphamide;Data;DNA Damage;Doxorubicin;executive function;experimental study;exposed human population;Female;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genotype;hippocampal atrophy;Hour;Human;human data;human tissue;Impaired cognition;Impairment;in vivo;Individual;Inflammation;Inherited;insight;Intervention;Knock-in Mouse;learned behavior;Learning;male;Malignant Neoplasms;Measures;Memory;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;neurogenesis;Neurologic;Neurons;novel;old mice;oxidative damage;Paclitaxel;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Population;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Prevention;Prevention approach;Preventive treatment;Process;receptor for advanced glycation endproducts;Regimen;Reproducibility;resilience;Risk;risk variant;senescence;side effect;Structure;Synapses;Tamoxifen;tau-1;Testing;Therapeutic;therapeutic evaluation;Time;Tissue Sample;Tissues;Translating;tumor progression

PROJECT_TITLE: APOE4 promotes pathogenesis in a mouse model of cancer chemotherapy-induced cognitive impairment


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Estrogen;Menopause;Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Women are at elevated risk of developing psychosis during the menopause transition, but the clinical, demographic, and neural factors predisposing to that risk remain poorly understood. Prediction of risk for developing psychosis earlier in life has benefitted from the systematic study of the time period just preceding the onset of frank psychosis–the psychosis prodrome. We propose to study the prodrome both retrospectively and prospectively in women during the menopausal transition, with the goal of identifying specific risk factors for development of psychosis during this high-risk period.

PI_NAMEs: POWERS, ALBERT R (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Admission activity;Adolescence;Age;Aging;Applications Grants;Attenuated;attenuated psychosis syndrome;behavior prediction;Behavioral;Belief;Biological Markers;Clinical;clinical high risk for psychosis;cohort;comorbidity;Data;Development;Diagnosis;Disabling;Disease;dysphoria;Early identification;early psychosis;Early treatment;Electrophysiology (science);Elements;emerging adult;Endocrinology;Epidemiology;Estradiol;Estrogen decline;Estrogens;Evaluation;Exhibits;experience;Family;first episode psychosis;functional decline;Funding Opportunities;Future;Gender;Goals;high risk;Hormonal;Hormones;Image;improved;Incidence;Individual;Intervention;Interview;Life;life span;Medical;Medical History;men;Menopause;Menstrual cycle;Mental Depression;Mental disorders;Moods;National Institute of Mental Health;neural;Neurobehavioral Manifestations;Neurobiology;neuroprotection;Outcome;Participant;Performance;Perimenopause;Persons;Phase;Placebos;Population;Postpartum Depression;Postpartum Period;Predisposing Factor;Pregnancy;Premature Menopause;Progesterone;prospective;Prospective Studies;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Randomized, Controlled Trials;Recording of previous events;recruit;Relative Risks;Reporting;reproductive;reproductive hormone;response;Retrospective Studies;Risk;Risk Factors;Risk Marker;risk mitigation;risk prediction;risk stratification;Schizophrenia;schizophrenia risk;Semantics;Severities;sex;Source;Structure;symptomatic improvement;Symptoms;System;Testing;theories;Time Study;treatment strategy;Unipolar Depression;Update;Vulnerable Populations;Woman;Women's cohort;Women's study;Work;young adult;Youth

PROJECT_TITLE: PREMAP - Predictors and Risk Evaluation for Menopause-Associated Psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project narrative The proposal will evaluate how HBV integrant-derived RNAs (id-RNAs) produced independently of HBV genome replication can influence the life cycle of HBV and HBV-associated pathogenesis, which may result in revision of the current model of HBV life cycle and justify id-RNAs as important targets for novel anti-HBV interventions.

PI_NAMEs: GUDIMA, SEVERIN O (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Affect;Aftercare;analog;Anti-viral Agents;Automobile Driving;Binding;Biological Assay;Cells;Chronic;Chronic Hepatitis B;Code;Complement;Data;design;DNA Integration;env Gene Products;FDA approved;Genome;Genotype;Harvest;HBV Genotype;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis Delta Virus;Hepatocyte;Human;Individual;interferon therapy;Intervention;Knowledge;Length;Life Cycle Stages;Light;Liver;liver biopsy;Liver diseases;Maintenance;Messenger RNA;Modeling;Mutation;novel;Open Reading Frames;Pathogenesis;patient subsets;Patients;Persons;Pharmaceutical Preparations;Poly(A)+ RNA;prevent;Primary carcinoma of the liver cells;Production;Property;Research;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Stability;Role;Sampling;Serum;Signal Transduction;single-cell RNA sequencing;Source;Surface Antigens;Suspensions;Testing;Tissues;transcriptome sequencing;Untranslated Regions;vector;Viral;Virion;Virus;Work

PROJECT_TITLE: Influence of integrant-derived HBV RNAs encoding the envelope proteins on HBV life cycle

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Skeletal muscle stem cell transplantation is emerging as a promising strategy for treating muscle-associated trauma and disorders, but the paucity in their quantity limits their therapeutic potential. The inability to maintain and expand these cells ex vivo further compounds this challenge. This research will develop a geometrically asymmetric culture platform that enable long-term maintenance and expansion of muscle stem cells by directing cellular polarity, division, and fate determination.

PI_NAMEs: HAN, WOOJIN  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Adhesives;adult stem cell;aging population;Apical;Basal lamina;beta catenin;Biochemical;Biocompatible Materials;Biological Assay;Biomechanics;Biophysics;Cachexia;Cell Culture System;Cell division;Cell Polarity;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Centrosome;combinatorial;Cues;design;Disease;Dystrophin;Economic Burden;Elasticity;Employment;Engineering;Engraftment;Epidermal Growth Factor Receptor;Ethylenes;Genes;Glycols;Hydrogels;In Vitro;Integrins;Life Cycle Stages;Ligands;Maintenance;mechanical force;mechanical stimulus;Mechanics;mimetics;Mitotic spindle;Muscle;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Myogenin;Outcomes Research;Patients;Peptides;Physiological;planar cell polarity;Proliferating;Proteins;receptor;Regenerative Medicine;Regulation;Research;Role;sarcopenia;segregation;self-renewal;Signal Transduction;Skeletal Muscle;socioeconomics;Source;Specific qualifier value;stem cell biology;stem cell division;stem cell expansion;stem cell niche;Stem cell transplant;stem cells;stemness;Stretching;System;Testing;Therapeutic;Transplantation;Trauma;volumetric muscle loss

PROJECT_TITLE: Engineered Asymmetric Hydrogel for Muscle Stem Cell Polarity and Fate Specification

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Program Director/Principal Investigator (Last, First, Middle): Kozar, R/ Dong JF Project Narrative Hemorrhagic shock remains the most common cause of early deaths after trauma. The proposed research will provide mechanistic insight into shock-induced endothelial dysregulation and subsequent coagulopathy and will test potential therapeutics to reduce these pathologic sequalae of shock to improve outcomes. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: DONG, JING-FEI ;KOZAR, ROSEMARY A (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;ADAMTS;Adhesives;Anti-Inflammatory Agents;Antibodies;Anticoagulants;Binding;Blood;Blood Cells;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood Vessels;Carbohydrates;Cause of Death;Cells;Cessation of life;Clinical;Complex;Cysteine;Data;Development;disability;Endothelial Cells;Endothelium;enhancing factor;Environment;experimental study;Exposure to;extracellular vesicles;Failure;Fluorescence Resonance Energy Transfer;Foundations;Functional disorder;Glycocalyx;hemodynamics;Hemorrhage;Hemorrhagic Shock;Hemostatic Agents;hypoperfusion;improved outcome;In Vitro;in vitro activity;Inflammatory;injured;Injury;innovation;insight;Ischemia;Lead;Leukocytes;Ligands;Measures;Mediating;Membrane Lipids;Membrane Microdomains;Metalloproteases;Microscopy;Modality;Molecular Conformation;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutics;oxidation;Oxidation-Reduction;Oxidative Stress;Oxygen;Pathologic;Pathway interactions;Patients;Plasma;prevent;preventable death;Principal Investigator;programs;Proteins;Proteomics;Publishing;receptor binding;Recombinants;Research;response;Resuscitation;Risk Assessment;Role;Rosemary;Sampling;Secondary to;severe injury;Severities;Shock;Site;Structure;Sucrose;Surface;syndecan;System;Techniques;Testing;Therapeutic;Therapeutic Agents;Thrombophilia;thrombotic;Time;Tissues;TNF-alpha converting enzyme;Trauma;Trauma patient;Traumatic Brain Injury;Ultracentrifugation;vascular injury;von Willebrand Factor

PROJECT_TITLE: Trauma and Shock-Induced Microvascular Dysregulation and Coagulopathy


NIH_SPENDING_CATS: Aging;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Skeletal muscle regeneration is critical for maintaining muscle structure and function following damage; however, older adults have impaired tissue regeneration, which leads to age-related skeletal muscle tissue remodeling, deterioration, and loss of independence. Appropriate therapies to improve muscle regeneration in older adults are needed, but the development of therapies is limited by the current understanding of nutrient and metabolic requirements of the regenerative process. This research is directly relevant to the NIH mission because it aims to understand a potential therapeutic target, serine and glycine metabolism, for the overall improvement of skeletal muscle regeneration and, thus, for the improvement of skeletal muscle health in the aging population.

PI_NAMEs: THALACKER-MERCER, ANNA E. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Activities of Daily Living;Address;Adipocytes;Adipose tissue;Affect;Age;age related;age related decline;age-related disease;age-related muscle loss;aged;Aging;aging population;Amino Acids;Biochemical;Biological Assay;Biology;cell age;Cell Count;Cell Proliferation;Cells;Cellular Metabolic Process;Cellular Stress;Coupled;Creatine;Data;Deterioration;Development;Diet;dietary;efficacy evaluation;EIF-2alpha;Elderly;Environment;extracellular;Fatty acid glycerol esters;Glutathione;Glycine;Goals;hallmarks of aging;Health;Homeostasis;Image;Impairment;improved;in vivo;Infiltration;Inflammation;injured;Injury;Intramuscular;Isotopes;Knowledge;Label;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mission;Modeling;Morphology;Mus;Muscle;Muscle Cells;Muscle function;muscle progenitor cell;muscle regeneration;Muscular Atrophy;muscular structure;Myopathy;Natural regeneration;Non-Essential Amino Acid;novel;Nutrient;Nutrient availability;Nutritive Value;Obesity;older adult;Outcome;Oxidative Stress;Pathologic;Phosphorylation;Physical Function;Physiological;Population;Process;programs;Protein Biosynthesis;Quality of life;regenerative;Regenerative capacity;Research;Risk;Serine;Skeletal Muscle;Sphingolipids;stem;stem cell expansion;stem cell function;stem cell population;stem cell proliferation;stem cells;Supplementation;Testing;therapeutic target;therapy development;tissue regeneration;Tissues;transcriptome;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: The essentiality of serine and glycine for skeletal muscle regeneration in aging

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Cardiovascular disease (CVD) remains the leading cause of death in the US. This Training Program thus addresses a critical need to train individuals in cardiovascular epidemiology, ultimately to better prevent CVD. Our Training Program reflects the changing needs of our trainees in research in cardiovascular epidemiology and aims to produce independent cardiovascular epidemiologists in multidisciplinary research settings competent in traditional as well as novel epidemiological methods in CVD.

PI_NAMEs: SEKIKAWA, AKIRA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: cardiovascular disorder epidemiology;Training Programs

PROJECT_TITLE: Cardiovascular Epidemiology Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: IOWA CITY VA MEDICAL CENTER

PHR: The Center for the Prevention and Treatment of Visual Loss (CPTVL) provides new discoveries for restoring vision and related brain functions, which are important to a Veteran’s independence and quality of life. This is done through creative and scientifically rigorous interactions between clinicians and scientists who perform research in three main focus areas: 1) Rehabilitation of Vision Loss, 2) Ocular Biomarkers for Rehabilitation of Central Nervous System Disease, and 3) Technology Development, including Automated Telemedical Assessment of Ocular Disorders and Assistive Technologies. Research is translated with the goal of rehabilitating and restoring visual function. Examples of disorders that are targeted for rehabilitation include glaucoma, diabetic retinopathy, diabetic peripheral neuropathy, macular degeneration, traumatic brain injury, optic neuropathy, multiple sclerosis, light sensitivity, and migraine.

PI_NAMEs: KARDON, RANDY H. (contact);KUEHN, MARKUS H.

PROJECT_TERMS: 3-Dimensional;Affect;Area;Artificial Intelligence;Biological Markers;Blindness;Blinking;Brain;Cardiovascular system;Cell Culture Techniques;Central Nervous System;Central Nervous System Diseases;Cities;Clinical Trials;clinically relevant;CNS degeneration;community clinic;Creativeness;Dedications;Device or Instrument Development;diabetic;Diabetic Neuropathies;Diabetic Retinopathy;Diagnosis;Disease;Disease Progression;Early Diagnosis;Environment;Esthesia;Eye;Eye diseases;Eye Movements;Eyelid structure;Facial Muscles;General Population;Glaucoma;Goals;Home;Immune system;innovation;insight;Iowa;Link;Machine Learning;Macular degeneration;Mediating;Migraine;military veteran;Mission;Monitor;Movement;Multiple Sclerosis;Nervous System;Nervous System Disorder;Nervous System Physiology;Neuro-Ocular System;Neurologic Deficit;Neurologic Symptoms;ocular imaging;ophthalmic examination;optic nerve disorder;Outcome Measure;Pain;patient response;Peripheral Nervous System Diseases;personalized medicine;Photophobia;Pre-Clinical Model;Prevention;Pupil;Quality of life;Reflex eye movement;Rehabilitation therapy;Research;Scientist;Self-Help Devices;sight restoration;Specialist;Staging;Structure;Technology;technology development;Telemedicine;Testing;Translating;Traumatic Brain Injury;treatment response;Vascular Diseases;Veterans;Vision;Vision Disorders;vision rehabilitation;Visual;Visual impairment;Visual Perception

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Musculoskeletal diseases are the most common and disabling of conditions for Veterans. More than 1 in 3 suffer from osteoarthritis, the most common cause of disability and pain and termination of service. Our CReATE Motion Center will directly address this clinical need, across the spectrum of disease, by fostering a critical mass of expertise and a culture of innovation at the CMC VAMC in Philadelphia and the Atlanta VAMC. We will build on our cutting-edge infrastructure, extensive scientific foundation, and culture of mentoring and collaboration to establish a VA-based pipeline to move next-generation regenerative therapies from the laboratory to the patients that need them. Our CReATE Motion Center will restore joint health and mobility to Veterans, fulfilling the promise of regenerative therapies in the 21st Century.

PI_NAMEs: MAUCK, ROBERT L (contact);SCANZELLO, CARLA ROSE

PROJECT_TERMS: Acceleration;Address;Area;Arthritis;arthropathies;Award;Biological;Biomanufacturing;Biomedical Engineering;Cartilage;cartilage regeneration;Cell Therapy;Cells;Chalk;Clinic;Clinical;clinical care;clinical implementation;clinical translation;Collaborations;commercialization;Communities;Degenerative polyarthritis;design;disability;Disabling condition;Disease;Education;Education and Outreach;Educational workshop;Fellowship Program;Fostering;Foundations;functional restoration;Funding;Health;Infrastructure;innovation;joint function;joint injury;Joints;Knowledge;Laboratories;Medical center;Medicine;Mentors;Mission;Modeling;Motion;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Natural regeneration;neurosurgery;next generation;novel;Orthopedic Surgery;outreach;Pain;Patient Education;Patients;Peer Review;Pennsylvania;Philadelphia;Physical Medicine;Physical Rehabilitation;Process;programs;Regenerative Medicine;regenerative therapy;Rehabilitation therapy;repaired;Research;research clinical testing;Research Personnel;Resources;restoration;Scientific Advances and Accomplishments;Scientist;Series;Services;System;Techniques;Technology;Tissue Engineering;tool;Training;translational pipeline;Translational Research;Translations;Universities;Veterans

PROJECT_TITLE: CReATE Motion Center:  Cartilage Regeneration using Advanced Technologies to Enable Motion


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

PHR: PROJECT NARRATIVE  We hypothesize manipulating brain energy metabolism through a ketogenic diet (KD) will benefit Alzheimer's disease (AD) patients. To test this, we will randomize AD participants to a three-month KD or Therapeutic Lifestyles Changes (TLC) diet intervention. We additionally include biomarker-based measures to define how a KD affects participant physiology, and to identify KD-related mechanisms of action.

PI_NAMEs: SULLIVAN, DEBRA K;SWERDLOW, RUSSELL H. (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;adiponectin;Affect;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease patient;Apolipoprotein E;Biological Markers;Blood Platelets;Brain;Carbohydrates;CCL2 gene;Citrate (si)-Synthase;Clinic;Clinical;Clinical dementia rating scale;clinical effect;Clinical Trials;Cognition;Cognitive;cognitive performance;cognitive testing;Controlled Study;cytochrome c oxidase;cytokine;Data;design;Development;Diet;Dietary Intervention;Energy Metabolism;Energy-Generating Resources;Enrollment;Eotaxin;Fasting;Fatty acid glycerol esters;feasibility trial;Feedback;Funding Opportunities;Future;Generations;Glucose;High Density Lipoproteins;Homeostasis;Human;Hydroxycholesterols;improved;Inflammation;Inflammatory;insight;Insulin;insulin sensitivity;insulin signaling;Intake;interest;Intervention;ketogenic diet;Ketone Bodies;Ketones;Ketosis;Lead;Life Style;Lipids;Literature;Low-Density Lipoproteins;Magnetic Resonance Spectroscopy;Measurement;Measures;Memory;mental state;Metabolic;Metabolism;Mitochondria;N-acetylaspartate;Nature;Outcome;Participant;pharmacologic;Physiological;Physiology;Plasma;post intervention;Prevention;primary endpoint;Production;Randomized;randomized, controlled study;Research;Research Personnel;secondary endpoint;Serum;Single-Blind Study;Strenuous Exercise;Stress;Sum;Symptoms;systemic inflammatory response;Testing;Therapeutic;therapeutic lifestyle change;TNF gene;Translating;Treatment Efficacy;treatment program;Triglycerides;Validation

PROJECT_TITLE: Validation and Mechanistic Interrogation of Metabolism Targeting for AD


PHR: Substance use (SU) disorders collectively represent the single most preventable cause of disease, disability, and death in the United States. Veterans are at higher risk than the general population for complications related to SU. Chronic pain is a risk factor for opioid drug use and is compounded by the other SU. Although SU and chronic pain both have a heritable component, isolating specific genes that affect risk across substances and that may also affect risk for chronic pain has been hampered by small sample sizes and ambiguous phenotypes. We will use the Million Veteran Program sample with SU phenotypes based on longitudinal quantity-frequency data from the VA electronic health record, and novel techniques in genome- wide association computational analysis to overcome the limitations of previous work and advance the field by enhancing the screening, diagnosis and treatment of multi-SU and SU disorders. Finally, incorporating pain phenotypes will help to elucidate the genetic variation that contributes to their frequent co-occurrence with SU.

PI_NAMEs: JUSTICE, AMY CAROLINE;KRANZLER, HENRY RICHARD (contact)

PROJECT_TERMS: Address;Admixture;Affect;African American population;Aging;Alcohol consumption;Alcohol Phenotype;Alcohols;American;Behavior;Cessation of life;chronic pain;chronic pain management;Clinical;Clinical assessments;Clinical Data;clinically relevant;Cohort Studies;Complex;Computer Analysis;Data;Data Reporting;Development;Diagnosis;disability;Disease;Dose;Electronic Health Record;Enrollment;Environmental Risk Factor;European;Frequencies;Functional impairment;Gene Frequency;General Population;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome wide association study;Health;Healthcare;Heritability;high risk;indexing;Individual;individual variation;innovation;interest;International Classification of Disease Codes;Joints;Latino Population;Link;Measurement;Measures;Mediation;Meta-Analysis;Modeling;morphine equivalent;never smoking;novel;Opioid;opioid use;Pain;pain score;Participant;Pathway interactions;Patient Self-Report;Patients;Pharmacy facility;Phenotype;pleiotropism;polysubstance use;Population;Population Group;Preparation;prescription opioid;Principal Component Analysis;programs;psychiatric genomics;Records;Risk;Risk Behaviors;Risk Factors;Role;routine care;Sample Size;Sampling;screening;Sensitivity and Specificity;Series;sex;Sex Differences;Single Nucleotide Polymorphism;Smoking Status;substance use;Substance Use Disorder;Surveys;Techniques;Time;Tobacco;Tobacco Phenotype;Tobacco use;trait;Twin Studies;United States;Validation;Variant;Veterans;wiki;Work

PROJECT_TITLE: Genetic Vulnerability for Sustained Multi-Substance Use in MVP


ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative The purpose of this research program is to further develop Conus as a sophisticated resource for study of nicotinic acetylcholine receptors. We will exploit the resulting compounds for applications in medicine. Toward this end, we will assess the mechanisms and sites of of action of analgesic conopeptides.

PI_NAMEs: MCINTOSH, J MICHAEL (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TITLE: Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Multiple sclerosis (MS) is the leading cause of non-traumatic disability of young adults, affecting over 1 million people in the USA. The cause of the disease is unknown, the mechanisms that underlie the pathology are poorly understood and treatments are only partially effective, necessitating innovative strategies to understand the disease and susceptibility factors. In the proposed study we will determine if unique miRNAs found in MS patients are potential therapeutic targets.

PI_NAMEs: LOVETT-RACKE, AMY E (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Autoimmune;Autoimmune Diseases;autoreactive T cell;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;central nervous system demyelinating disorder;CNS autoimmunity;Complement;cytokine;Data;Defect;Development;disability;Disease;Disease Progression;Disease susceptibility;Experimental Autoimmune Encephalomyelitis;experimental study;Failure;Functional disorder;Gene Expression;Genes;Human;Immune;In Vitro;in vivo;Individual;Inflammatory;inhibitor;innovation;Interleukin-6;Laboratories;Mediating;memory CD4 T lymphocyte;MicroRNAs;Modeling;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Nerve Degeneration;Neurologic Deficit;novel;overexpression;Pathology;Pathway interactions;Persons;Play;Population;Predisposition;prevent;Proteins;Receptor Signaling;Regulatory T-Lymphocyte;Risk;Risk Factors;RNA Interference Pathway;Role;Signal Pathway;Signal Transduction;T cell differentiation;T-Lymphocyte;Testing;Th1 Cells;Th2 Cells;therapeutic miRNA;therapeutic target;Transforming Growth Factor beta;young adult

PROJECT_TITLE: Role of miRNA Dysregulation on T Cell Differentiation and Function in MS

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative In the last decade, obesity has emerged a major public health challenge, with implications for several disease conditions, such as cardiovascular diseases, cancer and metabolic syndromes (e.g. type-2 diabetes and insulin resistance). This project investigates novel roles of angiogenesis-linked receptor, neuropilin 1 (Nrp1) in obesity-mediated dysfunctions. We propose that obesity and concomitant increase of circulating free fatty acids promote the expression and interaction of Nrp1 with insulin substrates, which impact vascular Nrp1 functions.

PI_NAMEs: DING, YE  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adipocytes;Adipose tissue;angiogenesis;Aorta;Attenuated;Binding;Binding Sites;blood glucose regulation;Blood Vessels;Cancer cell line;Cardiovascular Diseases;Cell Line;Cells;Cholesterol;comorbidity;Cytoplasm;Cytoplasmic Tail;Diet;Disease;Docking;Dose;Endothelium;epidemiologic data;Epidermal Growth Factor Receptor;Extracellular Domain;Fluorescein-5-isothiocyanate;Functional disorder;Glucose tolerance test;Glycoproteins;Growth Factor;Hemostatic function;Hepatocyte;High Fat Diet;High-Risk Cancer;Hypoxia;In Vitro;in vivo;Incidence;Inflammatory Response;insight;Insulin;Insulin Receptor;insulin receptor substrate 1 protein;Insulin Resistance;Insulin-Like Growth Factor I;KDR gene;Knockout Mice;Label;Link;Lipids;Liver;Malignant Neoplasms;Measurement;Mediating;Membrane;MET gene;Metabolic;metabolic abnormality assessment;Metabolic syndrome;Metabolism;mouse model;Mus;Muscle Fibers;Neuropilin-1;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Obesity;Pathologic;Phosphotransferases;Physiology;Play;Process;protein expression;Proteins;Public Health;receptor;Receptor Protein-Tyrosine Kinases;response;Role;Signal Pathway;Signal Transduction;Site;Testing;Time;Tissues;Transfection;Triglycerides;Tumor Angiogenesis;United States;Up-Regulation;vascular contributions

PROJECT_TITLE: Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Rehabilitation

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Binaural hearing (i.e. hearing with two ears) provides substantial benefits in complex listening environments. The proposed study will determine the contributions of different characteristics of auditory signals to binaural hearing. This will both deepen our understanding of the binaural auditory system and lay the groundwork for techniques that can help populations, such as cochlear implant users, who have difficulty making full use of binaural hearing.

PI_NAMEs: ARONOFF, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]