ORG_DEPT: CHEMISTRY

PHR: NARRATIVE: This proposal deals with large barriers in bacteriophage discovery. We will separate mixtures of bacteriophages using electrophoresis. We will determine the physico- chemical basis of fractionation. The technology developed here has obvious implications in antimicrobial development and as a census of phage genes for molecular exploitation. Thisproposal is in line with NIH mission statement to seek fundamental knowledge of the nature of living systems.

PI_NAMEs: CHAMPION, MATTHEW M (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TITLE: Development of an electrophoretic platform for bacteriophage discovery

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: The correlates of pathogenicity for filoviruses, including the highly fatal WHO priority pathogens Ebola and Marburg viruses, remain poorly understood. Inteins, or intervening proteins, can make and break peptide bonds in a controllable and specific manner, which has led to numerous impactful tools in protein engineering. The overall goals of this application are to develop novel intein-based technologies to better understand the expression and function of individual Ebola virus proteins during infection and disease progression.

PI_NAMEs: HUME, ADAM JOSEPH (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Algorithms;Amino Acid Sequence;Biomedical Research;candidate identification;Case Fatality Rates;Characteristics;Chemistry;Communities;Data;Defect;design;Development;Disease Progression;Ebola virus;Elements;emerging pathogen;Engineering;Escherichia coli;Filovirus;Fluorescence;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Growth;Housing;hybrid protein;improved;Individual;Infection;inhibitor;innovation;intein;invention;Investigation;Mammalian Cell;Marburgvirus;Mediating;Molecular;mutant;Mutation;novel;Pathogenesis;Pathogenicity;Peptides;prediction algorithm;Principal Investigator;priority pathogen;Property;Protein Engineering;protein function;Protein Inhibition;Protein Splicing;Proteins;Reaction;recombinant virus;Recombinants;Reporter;Reporter Genes;Reporting;Research;Research Personnel;RNA Splicing;Role;Serial Passage;Site;small molecule;System;Technology;Testing;tool;Transcription Coactivator;transcription factor;Translating;Variant;Viral;viral fitness;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Establishing intein-based tools to study filovirus replication

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Infections due to Acinetobacter baumannii are increasing in frequency and have become exceeding difficult to treat with antibiotics. This proposal will investigate the roles of GacA, sRNAs and CsrA in modulating Rho-dependent termination to regulate a phenotypic switch that controls virulence in A. baumannii. The completion of this study may lead to the development of novel approaches to inhibit virulence.

PI_NAMEs: RATHER, PHILIP N. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TITLE: CsrA mediated regulation of a virulence switch in Acinetobacter baumannii

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Endoplasmic reticulum (ER)-associated degradation (ERAD) is the principal ER quality control machinery responsible for the clearance of misfolded ER proteins for cytosolic proteasomal degradation. Recent studies from our laboratory have revealed the significance of ERAD in the maturation of nephrin within the ER of podocytes; however, the underlying molecular mechanism and significance of ERAD in podocytes remain largely unclear. This study will test an exciting hypothesis that SEL1L-HRD1 ERAD protein complex plays a critical role in maintaining ER homeostasis in podocytes by coordinating autophagy activation.

PI_NAMEs: QI, LING  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adult;Affect;Age;Autophagocytosis;Autophagosome;autosome;Biogenesis;Biology;Cell Count;Cell Death;Cell Physiology;Cell Survival;Child;clinically relevant;Complex;Data;Defect;Degradation Pathway;Disease;Electrons;Endoplasmic Reticulum;Ensure;Female;Filtration;Foot Process;gain of function;Growth;Health;Homeostasis;Human;Impairment;In Vitro;in vivo;insight;Integral Membrane Protein;interest;Investments;Laboratories;life span;Link;loss of function;male;Mediating;Microscopic;misfolded protein;Modeling;Molecular;mouse model;Mus;mutant;nephrin;Nephrotic Syndrome;Pathogenesis;Pathologic;Physiological;Physiology;Play;podocyte;premature;prevent;protein aggregation;protein complex;protein degradation;protein folding;Proteins;Proteinuria;Proteomics;Quality Control;response;Role;slit diaphragm;Structure;synergism;System;Testing;Therapeutic;Work;Yeasts

PROJECT_TITLE: Mechanisms of ER-Protein Quality Control in Podocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE We propose to develop a new class of heterobifunctional small molecules that can induce phosphorylation of any given protein-of-interest on demand by using kinase inhibitors. PHS 398/2590 (Rev. 06/09) 1  Continuation Format Page

PI_NAMEs: CHOUDHARY, AMIT  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acceleration;Active Sites;Address;Affinity;Agammaglobulinaemia tyrosine kinase;amino group;Binding;Biological;cell type;Cells;Charge;Chemicals;Chemistry;Chimera organism;Complex;Cysteine;Data;Deposition;Development;Disease;Electrostatics;Endowment;Enzyme Induction;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Exploratory/Developmental Grant;Fibroblast Growth Factor Receptors;Future;Generations;Guanosine Triphosphate;HLA Antigens;Hyperactivity;Immune response;Immune system;immunogenicity;inhibitor;interest;JAK3 gene;kinase inhibitor;KRAS oncogenesis;KRAS2 gene;Label;loss of function;Lysine;Mediating;Methods;multidisciplinary;mutant;Nature;neoantigens;non-Native;overexpression;Pathway interactions;Peptides;Pharmaceutical Preparations;Phospholipids;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;pressure;programs;Proteins;Proteomics;recruit;Reporting;Research;residence;Signal Transduction;small molecule;Specificity;Structure;Sulfhydryl Compounds;Testing;Therapeutic;Time

PROJECT_TITLE: Development of phosphorylation editing chimeras using kinase inhibitors

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: FORT COLLINS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed technology will help surgeons to treat young patients who have difficulty breathing due to narrowed airways, a potentially life-threatening condition. Currently, surgeons perform either a very complicated surgery, or they open the front of the trachea with an incision and use rib cartilage to hold the trachea open. The technology is an off-the-shelf trachea patch that will replace the need to harvest rib cartilage, allowing the patient to breathe normally without the need to harvest cartilage from the rib.

PI_NAMEs: TOWNSEND, JAKOB  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 3D Print;Acceleration;Address;Age;angiogenesis;Animal Model;Area;Award;Biocompatible Materials;Biological Factors;blood vessel development;Blood Vessels;BMP7 gene;bone;Breathing;Breeding;Cartilage;cartilage regeneration;cartilage transplantation;CCL2 gene;Cell Count;Cells;Child;Childhood;clinical translation;Communities;Complex;Complication;Consumption;controlled release;cost;Country;cytokine;Defect;design;Devices;Diamond;Encapsulated;Environment;Event;fabrication;Fiber;Flow Cytometry;Funding;Goals;Growth Factor;Guided Tissue Regeneration;Harvest;healing;Heart;Histology;Homing;improved;in vivo;Individual;Industry Collaboration;Infection;Inflammatory;Injury;Insurance;Knee;Left;Legal patent;Life;Literature;Macrophage;Marketing;Mechanics;Methods;microCT;Modeling;Morbidity - disease rate;Morphology;mouse model;nanofiber;nanofiber patch;Nanofiber Scaffold;Natural regeneration;Nature;next generation;Operating Rooms;Operative Surgical Procedures;Organ;Oryctolagus cuniculus;Otolaryngologist;Pain;Patients;Phase;Play;Population;Procedures;Proteins;Qualifying;Quality of life;reconstruction;Recovery;recruit;regeneration potential;repaired;response;rib bone structure;scaffold;Secondary to;sex;Shapes;Signal Transduction;Signaling Protein;Site;Skin;Slide;Small Business Innovation Research Grant;standard of care;stem;Stenosis;subcutaneous;Surgeon;Surgical complication;Surgical incisions;Technology;Testing;Time;Tissue Engineering;tissue regeneration;Tissues;Trachea;Tracheal Stenosis;transforming growth factor beta3;United States National Institutes of Health;Vascular Endothelial Growth Factors;Vascularization;wound healing

PROJECT_TITLE: Nanofiber Patch with Gradient Presentation of Biomolecules for Treatment of Pediatric Tracheal Stenosis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Rheumatoid Arthritis;Telehealth

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative In rheumatology practice there is an unmet need for a system that can collect accurate information on disease activity during telehealth consultations. We will implement and validate a new technology that uses smartphone cameras to capture visual measures of joint-specific information such as range of motion and joint swelling. The technology can lead to faster and more precise measurement of symptoms in telehealth visits to optimize medication and therapy interventions.

PI_NAMEs: HOWE, ROBERT D (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adopted;Adoption;Adult;Affect;Agreement;Algorithms;Amendment;Articular Range of Motion;Autoimmune Diseases;Biological Markers;Bluetooth;Cellular Phone;Clinic;Clinical;clinical examination;Computer Vision Systems;Consultations;cost;cost effective;COVID-19 pandemic;Data;Decision Making;Detection;Development;disability;Disease;Early Diagnosis;Elbow joint structure;Evaluation;Feasibility Studies;feasibility testing;Feedback;Flare;follow-up;Frequencies;Functional impairment;functional status;Future;Goals;Hand;Hand Strength;handheld mobile device;health assessment;Health Services Accessibility;Hospitalization;Hospitals;Immune system;improved;indexing;Investigation;Isometric Exercise;joint inflammation;joint injury;Joints;Laboratories;laptop;Measurement;Measures;Metacarpophalangeal joint structure;Methods;Monitor;Motion;Movement;new technology;novel;novel marker;older adult;Pain Measurement;pain reduction;pandemic disease;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phase;Quality of life;Questionnaires;remote assessment;remote monitoring;Reporting;Research Personnel;Resources;response;Rheumatoid Arthritis;rheumatologist;Rheumatology;Running;Self-Examination;Shapes;Swelling;Symptoms;Synovitis;System;Techniques;Technology;telehealth;Telemedicine;Testing;therapeutic effectiveness;Therapeutic Intervention;Thick;treatment response;urgent care;usability;video chat;Vision;Visit;Visual;web app;web platform;Woman;Wrist joint;young adult

PROJECT_TITLE: Video Disease Activity Index: A novel video measure to monitor rheumatoid arthritis in telehealth

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE This project is aimed to translate our engineered extracellular vesicles (EVs) into effective cancer therapy. We will optimize cytotoxicity and immune stimulatory functions of DR5 agonistic scFvs armed EVs and test these designer EVs in mouse clinical trials. We will then optimize bioprocessing and standardize workflow for the EVs production. This work will prepare our designer EVs to be explored as an alternative therapy for CAR-T cells.

PI_NAMEs: XU, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Adverse reactions;Alternative Therapies;animal imaging;Antibodies;Biodistribution;Biogenesis;biophysical properties;bioprocess;cancer cell;cancer infiltrating T cells;Cancer Model;cancer therapy;CAR T cell therapy;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;clinical translation;Clinical Trials;cytokine;cytotoxic;cytotoxicity;DNA;Dyes;Engineering;extracellular vesicles;Fibroblasts;Human;humanized mouse;Hypoxia;imaging study;Immune;Immunotherapy;In Vitro;in vivo;in vivo Model;Induction of Apoptosis;Infiltration;Interleukin-15;interleukin-21;Killer Cells;Knock-out;Label;Lentivirus Vector;Life;Ligands;Lymphoblastic Lymphoma;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Melanoma;Melanoma Cell;Melanoma patient;Modeling;Mus;mutant;Mutation;Myeloid-derived suppressor cells;Nature;neoplastic cell;Normal tissue morphology;novel;patient derived xenograft model;Patients;Penetration;Pharmacodynamics;Platelet-Derived Growth Factor Receptor;Procedures;Process;Production;programs;Qualifying;Quality Control;Resistance;response;Safety;Skin Cancer;Small Interfering RNA;small molecule;Solid;Standardization;Surface;Suspensions;T-Lymphocyte;targeted treatment;Testing;Therapeutic Effect;Therapeutic Studies;TNFRSF10B gene;Toxic effect;Transfection;Translating;Transmembrane Domain;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;Tumor Necrosis Factor Receptor;tumor-immune system interactions;vector;Work;Xenograft procedure

PROJECT_TITLE: Designer extracellular vesicles for cancer therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: TOLEDO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative Autism and neurodevelopmental disorders are commonly caused by a combination of multiple interacting environmental and genetic risk factors, and yet research on combined autism risk is underdeveloped. Here, we propose to study the interaction between a genetic risk factor (Shank3 haploinsufficiency) and an environmental risk factor (developmental exposure to the pyrethroid pesticide deltamethrin) in the prairie vole, a wild rodent with highly sophisticated social behaviors. We will leverage this model to test for the dose- dependent effects of pyrethroid exposure during development on Shank3 and wild-type prairie voles, with a focus on autism-relevant behaviors and the MAPK/mTOR signaling pathways as outcomes.

PI_NAMEs: BURKETT, JAMES  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: AKT1 gene;Animal Model;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Biological;Biological Markers;Blood;Blood specimen;Brain;Breeding;Caring;Child;Circadian Dysregulation;Circadian Rhythms;Cities;Cognition;Cognitive;Communication;communication behavior;Complex;Corpus striatum structure;Data;decamethrin;Dendritic Spines;density;design;Development;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;Disease;disorder risk;Dopamine;Dopamine D2 Receptor;dopamine transporter;Dose;Environmental Risk Factor;epidemiology study;Etiology;Exhibits;experimental study;Exposure to;Fathers;FRAP1 gene;Functional disorder;General Population;Genes;Genetic;genetic risk factor;genetic selection;Goals;Heterozygote;Hippocampus;Human;Hyperactivity;Knowledge;Laboratories;Lactation;Lead;Learning;Link;loss of function mutation;MAP Kinase Gene;MAPK3 gene;Medical;Microtus;Modeling;Molecular;Mothers;Movement;mTOR Signaling Pathway;Mus;mutant;Mutation;Neurodevelopmental Disorder;Neurologic;Neurologic Deficit;offspring;Outcome;Pathway interactions;Pesticides;Phelan-McDermid syndrome;Phenotype;prairie vole;Predisposition;Prefrontal Cortex;Pregnancy;Prevalence;primary outcome;protein function;Publishing;pyrethroid;Rattus;repetitive behavior;Research;response;Risk;Risk Factors;Rodent;Signal Transduction;social;Social Behavior;social communication;Social Interaction;synaptic function;Testing;Time;Transgenic Organisms;Variant;vocalization

PROJECT_TITLE: Developmental pyrethroid exposure in the Shank3 mutant prairie vole as a 2-hit model for neurodevelopmental disorder risk

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Current access to liver transplant is limited by the number of viable organs, and the number of suitable grafts can be improved by increasing the liver’s ability to tolerate ischemic preservation. Hypothermic oxygenated machine perfusion, a novel preservation technique, decreases ischemic damage compared to conventional storage on ice, but the molecular pathways modulated remain largely unknown. This project will identify markers of early liver graft preservation injury affected by hypothermic oxygenated machine perfusion compared with conventional storage on ice to optimize liver graft utilization, and increase access to life-saving liver transplant.

PI_NAMEs: GUARRERA, JAMES V.;LUNSFORD, KERI ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Adverse event;Affect;Age;Allografting;bile duct;Bile fluid;Biliary;biobank;Biochemical;Biochemical Markers;Bioinformatics;Biological Assay;Biological Markers;biomarker identification;Biopsy;Cardiac Death;cell injury;Cell Physiology;cholangiocyte;Clinical;Clinical Trials;Collection;Cryopreservation;Data;Devices;early detection biomarkers;early phase clinical trial;Elderly;end stage liver disease;Europe;Exhibits;experimental study;Flavin Mononucleotide;Fluorescence;Flushing;Functional disorder;Future;Genetic Markers;Genomics;Genus Hippocampus;Goals;Hepatocyte;Histologic;Homeostasis;Hypoxia;Ice;IL8 gene;immune activation;Immunohistochemistry;Improve Access;improved;Incidence;indexing;Infiltration;Inflammation Mediators;Inflammatory;inflammatory marker;Infusion Pumps;Injury;Interleukin-10;Interleukin-6;Ischemia;ischemic injury;Lead;Life;Liquid substance;Liver;liver allograft;liver injury;liver preservation;liver transplantation;Mediator;Metabolic;Metabolic dysfunction;metabolomics;Mitochondria;Molecular;Molecular Target;Monitor;Morbidity - disease rate;Multicenter Trials;nanoparticle;natural hypothermia;novel;Organ;Organ Donor;organ injury;Organ Preservation;Organ Procurements;Organ Transplantation;Organ Viability;Outcome;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Perfusion;Phase;pilot trial;portability;Postoperative Complications;potential biomarker;preservation;Preservation Technique;prospective;protective pathway;protein biomarkers;Proteins;proteogenomics;Proteome;Proteomics;Protocols documentation;Randomized;Randomized, Controlled Trials;Recovery;Reperfusion Therapy;Research;Risk;sex;Signal Transduction;Stains;standard of care;Stress;superoxide dismutase 1;System;targeted biomarker;Therapeutic;Time;tissue injury;Tissues;transcriptome sequencing;transcriptomics;Transplantation;Transplanted Liver Complication;trial comparing;Western Blotting

PROJECT_TITLE: Molecular Targets of Preservation Injury Mitigated by Hypothermic Oxygenated Machine Perfusion in Liver Transplantation

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOBOKEN

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Epilepsy is one of the most common neurological disorders and at least 3.4 million people in the U.S. live with seizures, with one third patients being drug-resistant and 50% still having persistent epilepsy after surgery. This project aims to develop an Electrophysiological Network Imaging framework to characterize the seizure onset zones and propagation pathways by an integration of scalp EEG and intracranial EEG to estimate the whole brain electrophysiological networks, based on a principled inference framework with the help of partially observable information from iEEG. The proposed framework can delineate the seizure onset zone and seizure propagation pathways, thus providing an improved epileptogenic zone identification accuracy and a reduced hospitalization time and risk for epilepsy patients.

PI_NAMEs: LIU, FENG  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Age;Biological Markers;Brain;Brain region;Clinical;clinical application;computerized tools;Data;Decision Making;Drug resistance;Electrodes;Electroencephalography;Electromagnetics;Electrophysiology (science);Epilepsy;Evaluation;Excision;Frequencies;Functional Magnetic Resonance Imaging;Generations;High Frequency Oscillation;Hospitalization;Image;improved;Learning;machine learning framework;Magnetoencephalography;Measurement;Methods;Modeling;multimodality;Nature;Nervous System Disorder;network models;Neurosciences;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Process;reconstruction;Refractory;Research Personnel;Resected;Risk;Scalp structure;Seizures;Signal Transduction;Source;source localization;surgery outcome;temporal measurement;Time;transmission process;Validation

PROJECT_TITLE: Epileptic Electrophysiological Brain Networks Modeling with Partially Observable Brain Regions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This proposal seeks to validate the first transabdominal, non-invasive fetal electroencephalogram (EEG) using data collected from fetal scalp electrodes during active labor. The system employs a novel artificial intelligence approach to reconstruct fetal EEG from electrophysiological signals collected from the maternal abdomen. Successful validation of this system has the potential of transforming fetal monitoring and brain development research in humans.

PI_NAMEs: CORTES-BRIONES, JOSE A;LEE, EMILY  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 5 year old;Abdomen;Algorithms;Artificial Intelligence;auditory stimulus;base;Biological Markers;Birth;Blinded;Brain;Brain Injuries;Brain Stem;Cardiac;Cause of Death;Cerebral Palsy;Cesarean section;Child;Clinical;Clinical Research;clinically relevant;comparative;computerized;Data;deep neural network;Dependence;Detection;Development;Diagnosis;disability burden;Discipline of obstetrics;Electrocardiogram;Electrodes;Electroencephalography;Electronics;Electrophysiology (science);Engineering;Enrollment;Evaluation;fetal;Fetal Development;fetal diagnosis;Fetal Monitoring;Fetal Movement;Fetus;fetus hypoxia;Foundations;Future;Goals;Heart Rate;Human;Hypoxia;improved;in utero;Incidence;Individual;interest;Interruption;Intervention;Lead;Life;maternal outcome;maternal risk;Measurable;Measurement;Measures;Methods;Monitor;Morphologic artifacts;Muscle;Neonatal Mortality;neonatal outcome;Nervous System Trauma;Neurodevelopmental Disability;Neurologic;Neurological status;Neurology;Newborn Infant;Noise;novel;novel strategies;Outcome;Oxygen;Participant;Patients;Pattern;Pediatrics;Perinatal;perinatal outcomes;preservation;prevent;prognostic;rate of change;reconstruction;recruit;Research;research and development;Residual state;response;Scalp structure;Signal Transduction;skills;System;Testing;Time;United States;Uterine Contraction;Vagina;Validation;voltage;Work

PROJECT_TITLE: Non-invasive abdominal fetal electroencephalography for fetal assessment


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE People with diabetes are susceptible to inflammatory morbidities associated with developing sepsis. However, the cellular targets involved in enhanced susceptibility to infection in this group of patients remain to be defined. This project will provide new fundamental knowledge regarding regulating inflammatory components, allowing us to take this work further in both basic and translational directions.

PI_NAMEs: SEREZANI, C. HENRIQUE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Acetylation;Affect;Affinity;Amino Acids;Animals;antagonist;ATP Citrate (pro-S)-Lyase;Automobile Driving;Blood;Cells;cellular targeting;Cessation of life;Chronic;comorbidity;cytokine release syndrome;Data;Death Rate;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;DNA;drug repurposing;effective therapy;EP300 gene;Epigenetic Process;Event;Exhibits;Exposure to;Gene Targeting;Genes;Genetic Transcription;Glucose;glucose monitor;Histone Acetylation;histone acetyltransferase;Histone H3;Human;Hyperglycemia;Immune response;improved;improved outcome;In Vitro;in vivo;in vivo imaging;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Insulin;Knowledge;Leukocytes;Leukotriene B;Leukotriene B4;Leukotriene Receptor;Link;lipid mediator;Lipids;LTB4R gene;Macrophage;Mediating;Memory;Metabolic;Metabolism;microbial products;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;mRNA Expression;Multiple Organ Failure;Mus;Myelogenous;Myeloid Cells;non-diabetic;novel strategies;Nuclear;Organ;organ injury;pathogen;Pathogenesis;Patients;Pattern;Peritoneal Macrophages;Persons;Phagocytes;Plasma;Play;Predisposition;prevent;Production;promoter;protective effect;Proteins;Publishing;receptor;receptor expression;Reporter Genes;response;Risk;risk mitigation;Role;Sepsis;septic;Serum;Severities;Signal Transduction;Staphylococcus aureus infection;System;Systemic infection;systemic inflammatory response;Testing;theories;Therapeutic;therapeutic development;Tissues;transcription factor;Transgenic Organisms;Translating;Treatment Protocols;Work

PROJECT_TITLE: Hyperglycemia and increased severity to Staphylococcus aureus infections.

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Hemorrhagic shock following a traumatic injury is a leading cause of preventable deaths in people aged 1-44 years old. To enhance treatment and clinical management of critically injured patients, this Diversity Supplement aims to investigate the impact of endovascular devices on fluid and medication requirements. Leveraging on an established preclinical model of hemorrhagic shock, the candidate will use novel quantitative methods including machine learning to understand the relationship between poor blood flow and heart performance with the goal of identifying improved patient monitoring algorithms.

PI_NAMEs: RAHBAR, ELAHEH  (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Acute;Address;aged;Algorithms;Aorta;Artificial Intelligence;Balloon Occlusion;Blood Coagulation Disorders;Blood flow;Blood Vessels;Cardiac;Center for Translational Science Activities;Cessation of life;Clinical;Clinical Management;clinically relevant;Comprehension;Critical Care;crystalloid;Development;Devices;Early identification;Educational workshop;Effectiveness;Environment;experience;Foundations;Goals;Grant;Heart;hemodynamics;Hemorrhage;Hemorrhagic Shock;Hemostatic Agents;hypoperfusion;Hypotension;Hypoxia;improved;improved outcome;indexing;Intervention;Ischemia;Knowledge;Life;Liquid substance;Machine Learning;machine learning model;Maintenance;Managed Care;Measures;medical schools;Medicine;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;multi-scale modeling;novel;parent grant;Parents;Patient Care;Patient Monitoring;Patients;Pattern;Performance;Perfusion;Persons;Pharmaceutical Preparations;Physiology;Pre-Clinical Model;pressure;preventable death;Procedures;programs;Research;research and development;Resources;response;Resuscitation;severe injury;statistics;symposium;Thoracotomy;Time;Tissues;Training;translational impact;Translational Research;Trauma;Trauma patient;Traumatic injury;Universities;Vasoconstrictor Agents;Work;Writing

PROJECT_TITLE: Development of a Multi-scale closed loop model for hemorrhagic shock: a platform to assess REBOA performance


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Lung cancers with mutations in KRAS and KEAP1 are notoriously difficult to treat and associated with poor outcomes in patients. We found these cancers can be killed by a histone deacetylase inhibitor drug, and by combination of this drug with a KRAS inhibitor that was recently FDA approved. In this grant we will determine the potential of this drug and drug combination to inhibit KRAS/KEAP1 mutant human lung cancers grown in mice, and identify the mechanisms involved.

PI_NAMEs: MAKI, CARL G (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acetylation;anticancer activity;Apoptotic;BCL2L11 gene;Biological Availability;Cancer cell line;Cancer Patient;Cell Death;Cell Line;Cells;Clinical;Clinical Research;clinically relevant;Data;Development;Drug Combinations;FDA approved;Genes;Grant;HDAC4 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;improved;inhibitor;inhibitor therapy;knock-down;KRAS2 gene;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mus;mutant;Mutate;Mutation;mutational status;Non-Small-Cell Lung Carcinoma;Outcome;overexpression;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Proteins;refractory cancer;Reporting;Resistance;response;Role;Series;targeted treatment;Testing;Toxic effect;tumor;Tumor Suppressor Proteins;tumor xenograft

PROJECT_TITLE: Synthetic lethal targeting of KRAS/KEAP1 co-mutant non-small cell lung cancer

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pediatric;Prevention;Vaccine Related

ORG_DEPT: PEDIATRICS

PHR: NARRATIVE Understanding the immune response to SARS-CoV-2 vaccination is important to improve vaccine efficacy in populations that are vulnerable and more at risk of developing complications from COVID-19. Patients with multiple sclerosis (MS) are on immunotherapies that can impact their immune system, affecting the quality of the vaccine response, particularly in children. Our study will assess the quality and duration of antibody and B- and T-cell responses, including neutralizing antibodies against SARS-CoV-2 infection, in vaccinated children and adults with MS undergoing different immunotherapy regimens, which may inform therapeutic decisions prescribed to vulnerable MS patients and identify critical immune pathways to boost the vaccination response in patients with MS and other patients on similar immunotherapies.

PI_NAMEs: GHOSN, ELIVER ;GOMBOLAY, GRACE YOONHEEKIM (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Admission activity;Adult;Affect;Age;age group;anti-CD20;Antibodies;Antibody Response;antigen detection;Antigens;Autoantibodies;Autoantigens;B cell therapy;B-Lymphocytes;Biological Assay;Cellular Immunity;Cessation of life;Child;cohort;Coronavirus;COVID-19 complications;COVID-19 mortality;COVID-19 patient;COVID-19 risk;COVID-19 severity;COVID-19 vaccination;Cytometry;Data;Development;Dimensions;Disease;Flow Cytometry;Future;high dimensionality;Hospitalization;Human;human coronavirus;Humoral Immunities;IgA1;IgA2;IgE;IgG1;IgG2;IgG3;IgG4;Immune;Immune response;Immune system;Immunization;Immunoglobulin M;Immunosuppressive Agents;Immunotherapy;Impairment;improved;Infection;Intensive Care Units;lymph nodes;Measures;Memory B-Lymphocyte;Messenger RNA;Monoclonal Antibody CD20;MS4A1 gene;Multiple Sclerosis;multiple sclerosis patient;neutralizing antibody;new technology;novel;Participant;Pathway interactions;Patients;pediatric multiple sclerosis;Phenotype;Plasma Cells;prevent;Production;Proteins;Regimen;response;Risk;Risk Reduction;rituximab;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 variant;Serology;severe COVID-19;Shapes;Specificity;Sphingosine-1-Phosphate Receptor;Structure of germinal center of lymph node;systematic review;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Technology;Therapeutic;Vaccinated;Vaccination;vaccination strategy;vaccine effectiveness;vaccine efficacy;vaccine response;vaccine strategy;Vaccines;variants of concern;Vulnerable Populations;Work

PROJECT_TITLE: Serological and cellular immune response to SARS-CoV-2 vaccination in pediatric multiple sclerosis on immunotherapy

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation;Telehealth

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal will evaluate the validity and reliability of mobile health technology to quantify movement of the hand and arm in children with hemiparetic cerebral palsy. Validating assessments that could extend into the home or other environments offers potential for measuring real-world performance that is not captured from existing clinical measures. Such assessment technology could be implemented in future work to expand the current knowledge of how children with hemiparetic cerebral palsy develop and respond to rehabilitation interventions.

PI_NAMEs: NEMANICH, SAMUEL THOMAS (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Affect;Age;Apple;arm;Cerebral Palsy;Child;Clinical;Clinical assessments;clinical practice;clinically relevant;Cohort Studies;cost efficient;Data;Development;Dyskinetic syndrome;Elements;Environment;Equipment;Evaluation;Exhibits;Family;finger movement;Fingers;flexibility;follow-up;Functional disorder;Future;Goals;grasp;Hand;handheld mobile device;Health Technology;hemiparesis;Home;Human Resources;Impairment;Individual;insight;Intervention;Investigation;joint mobilization;kinematics;Knowledge;Laboratories;limb movement;Limb structure;Link;Longitudinal Studies;Manuals;Measurement;Measures;Medical;Methodology;mHealth;mobile computing;Mobile Health Application;Monitor;Motion;Motor;motor control;motor impairment;Motor Skills;Movement;neurological rehabilitation;novel;Optics;Outcome;Outcomes Research;Output;Participant;patient engagement;Pattern;Performance;Perinatal Brain Injury;perinatal injury;Persons;Play;Positioning Attribute;prenatal;Property;Psychometrics;Quality of life;Questionnaires;Recovery;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;response;Sampling;sex;Site;software development;spatiotemporal;Standardization;synergism;Systems Development;Tablets;Techniques;Technology;Technology Assessment;telerehabilitation;Testing;Therapeutic Intervention;Time;touchscreen;Training;treatment planning;Upper Extremity;Upper limb movement;usability;Validity and Reliability;Visit;Visual;wireless data transmission;Wireless Technology;Work

PROJECT_TITLE: Game-based Mobile-Health Quantification of Upper-Limb Motor Performance in Children with Hemiparetic Cerebral Palsy

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Digestive Diseases;Estrogen;Liver Disease;Menopause;Nanotechnology;Precision Medicine;Women's Health Research

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE As mitochondria are fundamental to both cellular and organismal metabolic homeostasis, their dysfunction in aged women due to accumulated mitochondrial DNA mutations coupled with lack of circulating estradiol contributes to metabolic-associated steatotic liver disease. Thus, targeted mitochondrial delivery of estradiol has the potential to improve treatment for metabolic conditions in post-menopausal women. We will test whether mitochondria-targeted drugs with and without estradiol can correct age-related mitochondrial dysfunction in hepatocytes and menopausal mouse models.

PI_NAMEs: NEWELL-FUGATE, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acids;Affect;Age;age effect;age related;age-related disease;aged;Binding;Biogenesis;Cell Line;Cell Nucleus;Cells;cost;Coupled;covalent bond;Data;Deep Vein Thrombosis;Development;Disease;Disulfides;Drug Targeting;effective therapy;Elements;Enzymes;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;ethylene glycol;fatty acid oxidation;Fatty Liver;Female;Foundations;Functional disorder;Generations;Goals;Health;Healthcare Systems;Hepatic;Hepatocyte;HepG2;Homeostasis;Hormone replacement therapy;Impairment;improved;Individual;innovation;Link;lipid metabolism;Liver diseases;Malignant Female Reproductive System Neoplasm;Menopause;Metabolic;Metabolic Diseases;Metabolic dysfunction;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Molybdenum;Morbidity - disease rate;mouse model;mtTF1 transcription factor;Mus;nanoparticle;National Institute on Aging;Outcome;Ovariectomy;oxidation;Oxidative Phosphorylation;Oxygen Consumption;PGLA;Pharmacologic Substance;Play;Postmenopause;precision medicine;prevent;Production;Quality of life;Reactive Oxygen Species;Research;Research Personnel;Risk;Role;Selective Estrogen Receptor Modulators;SOD2 gene;Source;Stroke;targeted treatment;Testing;therapeutic nanoparticles;triphenylphosphine;Woman;Work

PROJECT_TITLE: Mitochondria-targeted therapy to improve metabolic health post-menopause

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Biotechnology;Hematology;Immunotherapy;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project narrative Graft versus host disease (GvHD) is a frequent outcome of hematopoietic stem cell transplants used to treat hematologic diseases, such as leukemia. We have identified a means of reducing GvHD by administering cells pre-treated with a purified bacterial molecule, exopolysaccharide (EPS). EPS is non-toxic and the goal of this grant is to use a humanized mouse system to optimize treatment and to determine how EPS-treated cells inhibit GvHD, leading to new drugs to prevent GvHD in humans.

PI_NAMEs: KNIGHT, KATHERINE L. (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Affect;Alloantigen;Allogenic;Antigens;B-Lymphocytes;Blocking Antibodies;Blood Cells;Body Weight decreased;CD34 gene;Cell Therapy;Cells;cellular engineering;Chronic;Clinical;Complication;Cryopreservation;Cytoprotection;Data;Dendritic Cells;Dioxygenases;Disease;dosage;Dose;Freezing;Goals;graft vs host disease;graft vs leukemia effect;Grant;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;HLA-A2 Antigen;Human;humanized mouse;Immune;Immunologics;improved;improved outcome;In Vitro;in vivo;indolamine;Inhibition of Cell Proliferation;inhibitor;Injections;Interleukin-10;Intervention;leukemia;Macrophage;Membrane;Metabolic;Mixed Lymphocyte Culture Test;Molecular;mouse model;Mus;Myeloid Cells;Natural Killer Cells;novel;novel therapeutics;Organ;Outcome;Patients;Peripheral Blood Mononuclear Cell;pre-clinical;prevent;Prevention;Probiotics;Process;programmed cell death ligand 1;prophylactic;Prophylactic treatment;Regimen;Regulatory T-Lymphocyte;response;Risk Factors;Sickle Cell Anemia;Signal Transduction;System;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Time;Tissues;Translating;Transplantation;transplantation therapy;treatment optimization;Umbilical Cord Blood;Xenograft Model

PROJECT_TITLE: Cell therapy for GvHD

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Dementia;Disability Research;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: CALIFORNIA PACIFIC MED CTR RES INSTITUTE

ORG_STATE: CA

PHR: SOMMA is a groundbreaking, highly productive and impactful study about the biological basis of mobility. SOMMA2 expands the cohort, adding power to test new hypotheses that pathways, such as DNA damage, play a role in disability, dementia and death and in the decline of muscle power and fitness with aging.

PI_NAMEs: CUMMINGS, STEVEN RON (contact);GOODPASTER, BRET H;HEPPLE, RUSSELL T;KRITCHEVSKY, STEPHEN B.;NEWMAN, ANNE B.

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: age related;age related changes;Aging;aging mechanism;Ancillary Study;Award;Biological;Biopsy;Blood;Cardiopulmonary;career development;Cell Aging;Cell Nucleus;cell type;Cells;Cessation of life;Clinical;cohort;Cohort Studies;Data;Data Set;Dementia;Denervation;design;disability;Disability outcome;DNA Damage;DNA Sequence Alteration;Ethnic Origin;Explosion;Fiber;fitness;follow-up;Foundations;Funding;Gene Expression;Gene Expression Profile;Gerontology;Goals;Grouping;Health;healthspan;Hematopoiesis;Human;Inflammatory;Intervention;Leg;Link;Lipids;Measures;Mitochondria;Mobility disability;Modification;Muscle;Muscle Cells;Muscle Mitochondria;Mutation;novel strategies;older adult;Older Population;Outcome;oxidative damage;Oxidative Stress;pandemic disease;Paper;Participant;Pathway interactions;Phenotype;Post-Translational Protein Processing;preservation;prevent;primary outcome;Printing;Process;Productivity;programs;Progress Reports;Property;Proteins;Publications;Publishing;Race;recruit;repaired;repository;Research;Research Personnel;Resources;Sampling;Scientist;senescence associated secretory phenotype;sex variable;single nucleus RNA-sequencing;Specimen;Testing;Time;Tissue-Specific Gene Expression;Transcript;transcriptome;transcriptomics;Translational Research;Walking

PROJECT_TITLE: Study of Muscle, Mobility and Aging: SOMMA2

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Recently, we introduced a transformative approach for cancer patient stratification by concurrently profiling canonical and modified miRNAs (miR isoforms), revealing intricate interactions influencing gene regulation. Current miR isoform-oriented resources lack user-friendly result consultation, missing the chance to uncover new cancer mechanisms. To address this gap and align with FOA objectives, we aim to develop isomiRGate, a free web-based gateway to comprehensively outline the broader miRNAome's function and regulation in cancer, including integrated methodologies and accessible data retrieval to discover novel cancer biomarkers.

PI_NAMEs: NIGITA, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Address;Adenosine;Adult;Affect;Age;American Cancer Society;anti-cancer research;Apoptosis;Architecture;base;Base Pairing;Biological Assay;Biological Markers;Cancer Biology;cancer biomarkers;cancer diagnosis;cancer genomics;Cancer Patient;cancer type;Cause of Death;clinical application;Code;cohort;Communities;Consensus;Consultations;Coupled;Data;data repository;Data Storage and Retrieval;design;Development;Diagnosis;Diagnostic;Disease;DNA;effective therapy;Epigenetic Process;epitranscriptomics;Event;experimental analysis;experimental study;Future;Gender;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;improved;in silico;innovation;Inosine;insight;Intuition;Investigation;Light;Malignant Childhood Neoplasm;Malignant Neoplasms;Messenger RNA;Methodology;Methods;MicroRNAs;migration;Modification;Neoplasm Metastasis;new therapeutic target;novel;online resource;Online Systems;Pathway Analysis;patient stratification;Patients;Pediatric Neoplasm;Persons;Play;Porifera;Post-Transcriptional Regulation;posttranscriptional;potential biomarker;prognostic;prognostic signature;Proliferating;Protein Isoforms;Quantitative Reverse Transcriptase PCR;Regulation;Regulator Genes;repository;Research;Resources;RNA;RNA Editing;Role;Sampling;statistics;Stratification;Testing;The Cancer Genome Atlas;Therapeutic;Time;tool;Transcript;tumor;tumor progression;United States;Untranslated RNA;user-friendly;Validation;web platform

PROJECT_TITLE: isomiRGate: a comprehensive gateway for studying the canonical and modified microRNAomes in Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: SEATTLE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  By 2050, osteoporosis is expected to affect >50% of Americans over the age of 50; further, osteoporotic hip fracture incidence is expected to increase by >200% compared to rates in 1990. Recent studies have identified a large number of loci associated with bone mineral density (BMD), an important clinical marker for osteoporosis diagnosis. This project aims to define causal genes at these loci to understand their biological mechanisms, and in turn, identify new drug targets for osteoporosis therapies.

PI_NAMEs: KWON, RONALD Y (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;Age;American;Bachelor's Degree;Biological;Bone Density;bone mass;career;career development;causal variant;Clinical;Clinical Markers;Development Plans;Diagnosis;Doctor of Philosophy;Environment;equity, diversity, and inclusion;experience;falls;Genes;genetic risk factor;Genetic Screening;Germ Lines;Goals;Grant;Health;Hip Fractures;Incidence;Individual;loss of function;Mentors;Mentorship;Minerals;mutant;new therapeutic target;novel;Osteoporosis;Osteoporotic;outreach;parent grant;Physicians;Postbaccalaureate;programs;Research;Research Project Grants;reverse genetics;Science;Scientist;Services;skills;symposium;Testing;Training;Work

PROJECT_TITLE: Diversity Supplement for Rohda Yase

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE Pathogenic mutations in the mitochondrial Lon protease cause a broad spectrum of rare developmental disorders, which include CODAS syndrome and profound neurological dysfunction. This exploratory project addresses a critical gap in our understanding about the mechanistic impact of Lon's binding to mitochondrial DNA (mtDNA) and its role in regulating mtDNA integrity and expression. By using innovative approaches and isogenic patient-derived cell lines expressing wild-type and mutant Lon proteins, we will elucidate the function and dysfunction of Lon not only in rare diseases, but also in common disorders in which Lon has been implicated (e.g., cancer, neurodegeneration and heart disease).

PI_NAMEs: SUZUKI, CAROLYN K (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;aerobic glycolysis;Alleles;Amish;ATP-Dependent Proteases;Bacteria;Bacterial Genome;Bacterial Proteins;Behavior;Binding;Biogenesis;biological adaptation to stress;Cell Differentiation process;Cell Line;cell type;Cells;Cellular Stress;cerebro-oculo-dento-auriculo-skeletal syndrome;Cerebrum;Childhood;chromatin immunoprecipitation;Cytoplasmic Granules;Cytosol;Data;Dental;Development;developmental disease;Disease;DNA Binding;Electrophoretic Mobility Shift Assay;Embryonic Development;endopeptidase La;Escherichia coli;Etiology;Fluorescence;Fluorescent in Situ Hybridization;Functional disorder;Gel;Gene Expression;Genes;Genetic Transcription;Genome;Glucose;Heart Diseases;Heat-Shock Response;Human;Image;Individual;induced pluripotent stem cell;innovation;insight;Knockout Mice;Knowledge;Life;Link;Maintenance;Malignant Neoplasms;Metabolic;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitochondrial Proteins;Mitochondrial RNA;Molecular Chaperones;mutant;Mutation;Myocardial dysfunction;Nerve Degeneration;nerve stem cell;Neurologic Dysfunctions;Neurons;Oligonucleotides;Opitz trigonocephaly syndrome;Outcome;oxidation;Oxidative Phosphorylation;Oxygen Consumption;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Peptide Hydrolases;Physiology;Play;Population;Production;programs;Property;protein degradation;Proteins;proteostasis;Rare Diseases;Research Personnel;Resources;response;Ribosomal RNA;RNA;Role;Shapes;single molecule;Single-Stranded DNA;skeletal;Specificity;Spottings;System;Transcript;Transcription Initiation;Transfer RNA;Translations

PROJECT_TITLE: Mechanistic etiology of developmental diseases caused by biallelic mutations in the mitochondrial Lon protease (111)

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: We will determine whether the ATG16L1 T300 isoform predominantly found in African Americans predisposes that patient population, over non-Hispanic whites who predominantly express the ATG16L1 A300 isoform, to tumors that present earlier, grow faster, metastasize more rapidly and that are predisposed to being killed by drug combinations which utilize autophagy as a killing mechanism versus standard of care therapies where autophagy acts to reduce drug efficacy. Outcomes of this work will define the concept that the ATGL16L T300T isoform is a prognostic indicator of response in AA CRC patients and represents a predictive treatment biomarker that can be used to inform treatment decisions and help to reduce disparate outcomes.

PI_NAMEs: DENT, PAUL  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: African American population;Alanine;Antitumor Response;Autophagocytosis;Autophagosome;Azoxymethane;Biological;Biological Markers;Biology;cancer cell;Cancer Etiology;cancer health disparity;cell killing;Cell Line;Cell Separation;Cells;chemically induced colitis;chemotherapy;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;Colorectal Neoplasms;Combined Modality Therapy;Competence;Complex;Crossbreeding;cytotoxic;Cytotoxic Chemotherapy;Data;differential expression;Disease;Disease Progression;disparity reduction;Drug Combinations;drug efficacy;Epithelial Cells;Female;Fibroblasts;field study;Frequencies;Genetic;Genotype;Goals;Growth;GRP78 gene;HCT116 Cells;health inequalities;improved outcome;In Vitro;in vivo;Incidence;inhibitor;Location;male;Modeling;Molecular Biology;Molecular Chaperones;mortality;Mus;Neoplasm Metastasis;Not Hispanic or Latino;novel;Outcome;outcome disparities;Paracrine Communication;patient population;Patients;Phosphorylation;Play;pre-clinical;Prediction of Response to Therapy;prognostic indicator;Protein Isoforms;response;Role;Sodium Dextran Sulfate;specific biomarkers;standard of care;Threonine;Time;Tissues;Transgenic Mice;Treatment Efficacy;Treatment Protocols;treatment response;tumor;Tumor Biology;tumor growth;tumor microenvironment;Up-Regulation;Vesicle;Work

PROJECT_TITLE: ATG16L1 isoforms and CRC health disparities

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Neurosciences;Nutrition;Prevention;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The proposed research study aims to identify whether a daily ketone supplement (KS) reduces the need for benzodiazepine medication to treat withdrawal and improves brain ketone and GABA metabolism in individuals with alcohol use disorder (AUD) during inpatient detoxification. The proposed study will generate fundamental knowledge on the potentially beneficial effects of a novel treatment for AUD and its underlying neural mechanisms. As a treatment for AUD, KS may offer a unique option: a dietary supplement whose use could obviate potentially dependence-producing benzodiazepine medication or augment its beneficial effects.

PI_NAMEs: NANGA, RAVI PRAKASH REDDY ;WIERS, CORINDE E (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Abstinence;abuse liability;Acetates;Acetoacetates;Acetone;Acute;Affect;Agitation;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Alzheimer's Disease;American;Aminobutyric Acids;Anxiety;Benzodiazepines;beta-Hydroxybutyrate;Brain;Brain Diseases;brain dysfunction;brain health;brain metabolism;Carbohydrates;Cessation of life;Chronic;chronic alcohol ingestion;Clinical;clinical effect;clinical efficacy;Clinical Research;Clinical Trials;Cognitive;cognitive performance;Collaborations;cost;craving;Delirium;Dependence;Development;Diet;dietary;Dietary Intervention;dietary supplements;dosage;Dose;drinking;Drug Metabolic Detoxication;dysphoria;eligible participant;Energy-Generating Resources;Epilepsy;Fatty acid glycerol esters;gamma-Aminobutyric Acid;Glucose;glucose metabolism;Glutamate Metabolism Pathway;Glutamates;Goals;group intervention;Hour;Human;Image;improved;Individual;individualized medicine;Inpatients;Intake;Intervention;Intoxication;ketogenic diet;ketogentic;Ketone Bodies;Ketones;Knowledge;Life;Magnetic Resonance Spectroscopy;Magnetism;Measures;Medical center;Metabolism;Methods;Monitor;Moods;neuroimaging;neuromechanism;Neurons;neurotoxicity;neurotransmission;novel;Nutritional;Oral cavity;Outcome;Participant;Patients;Pharmaceutical Preparations;Physicians;placebo group;Placebos;Plasma;preclinical study;Presbyterian Church;Protons;Psychiatry;Radiology Specialty;Randomized;Rattus;Recovery;Regimen;Relapse;Research;Research Personnel;research study;Rodent Model;Scanning;Seizures;Severities;Signal Transduction;Signs and Symptoms;Source;Spectrum Analysis;Structure;success;Supplementation;Taste Perception;Testing;Therapeutic Intervention;Tremor;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Ketone supplementation as an intervention to alleviate alcohol withdrawal and improve brain energetics in Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Contraception/Reproduction;Drug Abuse (NIDA only);Estrogen;Menopause;Mental Health;Neurosciences;Nutrition;Obesity;Substance Misuse;Women's Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE An increasing number of women are using cannabis products to treat their menopausal symptoms. Our research will investigate the causal relationship between endocrine status, aging, and cannabis exposure on mood, cognition, and metabolism, with the overarching goal of understanding how cannabis use during menopause alters aging trajectories.

PI_NAMEs: DELEVICH, KRISTEN MARIE (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acute;Address;Adherence;Affect;Affective;Affective Symptoms;Age;aged;Aging;Air;Anxiety;Behavior;Behavioral;Benefits and Risks;Bilateral;Body Composition;Brain;Cannabis;Chronic;Clinical Data;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;Consumption;Data;Dissociation;Drug Kinetics;Eating;Elderly;emotion regulation;Emotional;emotional behavior;Endocrine;endogenous cannabinoid system;energy balance;Estrogen Receptors;Estrogens;Excision;Exhibits;Exposure to;Female;female reproductive system;flexibility;Frequencies;Funding;Future;Glutamates;Goals;Health;hippocampal pyramidal neuron;Home;Hormone replacement therapy;Human;Impaired cognition;indexing;Informal Social Control;Inhalation;innovation;Legal;Link;marijuana use;marijuana user;Marketing;Measures;Medial;Medical Marijuana;Medicine;Menopausal Symptom;Menopause;Menstruation;Mental Depression;Metabolic;Metabolism;Modeling;Monitor;mood regulation;Moods;Motivation;Motor Activity;mouse model;Mus;negative affect;neural;neurobehavioral;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;novel;Obesity;Outcome;Ovarian;Ovarian Follicle;Ovariectomy;Ovary;Pattern;Persons;Pharmaceutical Preparations;Physical activity;Physiological;Physiology;Plants;poor health outcome;Population;Population Heterogeneity;Postmenopause;postnatal;pre-clinical;Pre-Clinical Model;Prefrontal Cortex;Progesterone;Recreation;Regimen;reproductive senescence;Research;Research Personnel;response;Rodent;Signal Transduction;Sleep;surgical menopause;Symptoms;Synapses;Synaptic Transmission;Testing;Tetrahydrocannabinol;vapor;vasomotor symptoms;Weight;Weight Gain;Withdrawal;Woman;Women's Group;Women's Health;young adult

PROJECT_TITLE: Mood, cognitive, and metabolic consequences of chronic vaporized cannabis exposure in mouse models of menopause

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (02)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Single cell genomic technologies enable systems-level characterization of individual cells and are rapidly transforming biomedical research. This proposal will develop a coordinated set of computational and statistical methods and software tools for unsupervised integrative analyses of single cell genomic data across multiple samples, different data modalities, and different species. These methods and tools will advance our understanding of both basic biology and human diseases by allowing scientists to use multi-sample single cell data to discover dynamic cellular and molecular programs associated with the variations in sample phenotype without prior knowledge about the sample phenotype.

PI_NAMEs: JI, HONGKAI  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;analytical method;analytical tool;Animal Model;ATAC-seq;Biological;Biological Process;Biology;Biomedical Research;Biomedical Technology;Cell Communication;cell type;Cells;comparative;computer framework;Computing Methodologies;Data;Data Analyses;data harmonization;data integration;data modalities;design;Detection;Development;Dimensions;Disease Progression;disorder subtype;epigenome;Experimental Animal Model;experimental study;Gene Expression;Genetic Transcription;genomic data;health care settings;Heterogeneity;Human;human disease;human model;Individual;Infrastructure;Investigation;Knowledge;Maps;Measures;Methods;Modality;Molecular;Noise;open source;Organ;Patients;Pattern;Persons;Phenotype;Population;programs;Research Personnel;Resolution;RNA;Sampling;Sampling Studies;Scientist;single cell analysis;single cell genomics;Software Tools;Statistical Methods;System;T-Cell Activation;Technology;temporal measurement;Time;Tissues;tool;transcriptome;transcriptome sequencing;tumor microenvironment;user-friendly;Variant;World Health

PROJECT_TITLE: Analytical Infrastructure for Multiple Sample Single Cell Genomic Data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Multiple hereditary exostoses (MHE) is a debilitating genetic disorder that affects one in every 50,000 children worldwide, and currently there are no approved therapies. The significance of this work lies in the development of novel screening assays to uncover new therapeutic targets for MHE and the potential for discovery of regulatory factors involved in heparan sulfate formation. This research is highly relevant to public health because the candidate genes identified in these studies represent new potential therapeutic targets for drug development to treat this orphan disease as well as other disorders where heparan sulfate formation goes awry.

PI_NAMEs: WEISS, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;autosome;Biochemical;Bioinformatics;Biological Assay;Candidate Disease Gene;Cartilage;Cartilaginous exostosis;Categories;Cell Line;Cell Separation;Cells;cellular transduction;Child;Chondrocytes;chronic pain;Compensation;CRISPR screen;CRISPR/Cas technology;deep sequencing;Defect;Deformity;Development;Disease;Disease Progression;DNA Sequence Alteration;drug development;drug discovery;Drug Targeting;druggable target;Elements;Enzymes;Epigenetic Process;Epiphysial cartilage;Exostoses;experience;Expression Profiling;EXT1 gene;FDA approved;Flow Cytometry;Fluorescence;functional genomics;functional restoration;Future;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Screening;Genetic Transcription;genome wide screen;genome-wide;Genomic DNA;Genomics;glycosyltransferase;Goals;Green Fluorescent Proteins;Growth;Growth Factor;Hela Cells;Heparan Sulfate Biosynthesis;Heparitin Sulfate;Hereditary Multiple Exostoses;Heritability;Heterozygote;Human;improved;In Vitro;Individual;innovation;knockout gene;Knowledge;Libraries;Liquid Chromatography;Location;long bone;loss of function;Loss of Heterozygosity;Malignant - descriptor;Mass Spectrum Analysis;Methods;Modeling;Molecular;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pain management;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Plasma;Population;prevent;Process;Proliferating;protein expression;Public Health;Quality of life;Rare Diseases;real time monitoring;Regulation;Reporter;Research;Research Project Grants;restoration;RNA Interference;Route;screening;Signal Pathway;skeletal;Sorting;Surgical Management;Techniques;Testing;therapeutic target;Tissues;Work

PROJECT_TITLE: Functional Genomics of Multiple Hereditary Exostoses


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PARENT R35 PROJECT NARRATIVE The active sites of central synapses are several times smaller than can be resolved using conventional approaches. Thus, much of what we know about the complex and dynamic processes involved in synaptic transmission has been inferred from indirect electrophysiological and/or biochemical assays. Our innovative nanoscale resolution imaging technology can visualize, track, and quantify presynaptic processes with single- vesicle resolution. We propose a research program based on this technology that promises to close the gap in our knowledge of synaptic transmission, including the role such processes play in the pathophysiology of Fragile X syndrome.

PI_NAMEs: KLYACHKO, VITALY A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Actins;Active Sites;Address;Area;autism spectrum disorder;Behavior;Biochemical;Biological Assay;Cognition;Complex;Cytoskeleton;Defect;Diagnostic;Disease;dynamic system;Electrons;Electrophysiology (science);Fragile X Syndrome;Functional disorder;Funding;Goals;Heritability;Imaging technology;innovation;Intellectual functioning disability;Knowledge;Lead;light microscopy;Link;Motor;Movement;Myosin ATPase;nanoscale;Neurobiology;novel;Parents;Play;postsynaptic;presynaptic;Process;programs;Recycling;Research;Resolution;Role;spatiotemporal;Synapses;Synaptic Transmission;Synaptic Vesicles;synergism;Technology;Therapeutic;Time;Tissues;translational impact;Vesicle;Visualization;Work

PROJECT_TITLE: Mechanisms of Synaptic Transmission in Healthy and Disease States


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE Schizophrenia is associated with disrupted activity of brain circuitry, precipitated by aberrant synaptic interactions between pyramidal and interneurons. Previously, we reported that Src kinase signaling, the hub of N-methyl-d- aspartate (NMDA) receptor pathway in the postsynaptic neurons, is reduced in schizophrenia, resulting from convergence of multitudes of molecular alterations schizophrenia. This project is designed to investigate how Src ad NMDAR signaling is altered distinctly in pyramidal neurons vs. interneurons.

PI_NAMEs: HAHN, CHANG-GYU  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Affect;Anterior;Autopsy;behavioral phenotyping;Binding;Biological Assay;Brain;brain circuitry;cell type;Characteristics;cohort;Complex;Dendritic Spines;density;design;DLG4 gene;embyronal Fyn substrate;excitatory neuron;Exhibits;Functional disorder;Genetic;glutamatergic signaling;Glutamates;Goals;hippocampal pyramidal neuron;Histologic;Immunoprecipitation;Incubated;inhibitory neuron;interest;Interneurons;Intervention;Label;Lead;Ligation;Liquid Chromatography;Mass Spectrum Analysis;Mediating;Methods;MFGE8 gene;Microscopic;Molecular;molecular phenotype;Monitor;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neural;neuroimaging;NMDA receptor A1;Parvalbumins;Pathology;Pathway interactions;Peptides;Persons;Phosphotransferases;postsynaptic;postsynaptic neurons;Prefrontal Cortex;protein complex;protein protein interaction;Proteins;Reaction;receptor;receptor function;Receptor Signaling;Reporting;Resolution;response;risk variant;Schizophrenia;schizophrenia risk;Series;Signal Pathway;Signal Transduction;src-Family Kinases;Superior temporal gyrus;Synapses;Synaptosomes;Testing;Therapeutic Intervention;therapeutic target;Tissues;Tyrosine Phosphorylation

PROJECT_TITLE: Cell type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: In this project, we will use state-of-the-art cryogenic electron tomography in situ (i.e., within cells) to understand how the filovirus nucleocapsid assembles inside cells. This work, combined with high-resolution structures, mutagenesis, and biochemical analyses, will deepen our understanding of filovirus replication processes and pave the way for the development of novel therapeutics to treat filovirus infections.

PI_NAMEs: SAPHIRE, ERICA OLLMANN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Anti-viral Agents;Binding;Biochemical;Biological Assay;C-terminal;Cell surface;Cells;Classification;Complex;Cryo-electron tomography;cryogenics;Cytoplasm;Data;density;Development;Disease Outbreaks;Ebola;Ebola virus;electron tomography;Elements;Fatality rate;Filoviridae Infections;Filovirus;flexibility;Genetic Transcription;Genome;Glycoproteins;Goals;Hand;Human;human pathogen;Immunosuppression;In Situ;Individual;insight;Ions;Knowledge;Life Cycle Stages;Location;Maps;Marburgvirus;Mediating;Modeling;mortality;Mutagenesis;mutant;Mutate;N-terminal;new technology;novel therapeutics;Nucleocapsid;Nucleoproteins;obligate intracellular parasite;Polymerase;Polymers;Population;Process;programs;protein purification;protein structure;Proteins;Recombinant Proteins;Recombinants;recruit;Replication-Associated Process;Resolution;RNA;RNA Binding;RNA replication;RNA Viruses;Sampling;Site;Sorting;structural biology;Structural Models;Structure;Techniques;Time;Transfection;Validation;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Inclusion Bodies;Viral Proteins;viral RNA;Virion;Virus;Virus Diseases;Virus Replication;Visualization;Work

PROJECT_TITLE: Filovirus nucleocapsid assembly, caught in the act, by in situ structural biology

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Prevention;Substance Misuse;Therapeutic Cannabinoid Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed study consists of a randomized, double-blind, counter-balanced, crossover behavioral pharmacology study of Δ9-Tetrahydrocannabivarin (Δ9-THCV) for individuals who smoke 10+ cigarettes per day. This study will test the initial efficacy of Δ9-THCV, which is essential for understanding the clinical potential of this naturally occurring cannabinoid as a treatment for tobacco use disorder.

PI_NAMEs: GRODIN, ERICA N;RAY, LARA A. (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abstinence;addiction;Agonist;Animal Model;Attenuated;Behavior;behavioral pharmacology;Binding;Biochemical;Cannabinoids;Carbon Monoxide;CB1 receptor antagonist;CB2 receptor antagonist;Chronic;Cigarette;cigarette craving;cigarette smoke;cigarette smoking;Clinical;Clinical Trials;CNR1 gene;CNR2 gene;craving;Cues;Development;Disease;Dizziness;Double-Blind Method;Effectiveness;Esthesia;FDA approved;Future;Human;human subject;improved;Individual;innovation;Laboratories;Laboratory Study;Measures;Methods;mouse model;Natural Products;Nausea;Nicotine;Nicotine Dependence;nicotine self-administration;Nicotine Withdrawal;Nicotinic Receptors;novel therapeutics;Oral;Outpatients;Participant;Pharmaceutical Preparations;Pharmacology Study;Pharmacotherapy;phytocannabinoid;Placebos;pre-clinical;Prevalence;preventable death;primary outcome;psychologic;Psychological reinforcement;Randomized;randomized, clinical trials;reduce tobacco use;Relapse;Reporting;Rewards;Sampling;satisfaction;Self Administration;Signal Transduction;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking initiation;substance use;Testing;Therapeutic;Therapeutic Agents;tobacco smokers;Tobacco use;Tobacco Use Disorder;Translating;United States;Visit;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Development of Tetrahydrocannabivarin as a Treatment for Smokers

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE The science is overwhelming that the climate of our planet is changing with little time to reverse course and climate action has the potential to benefit human health and address long standing health inequities; yet local health departments and health care systems—frontline defenders of the population’s health—have historically not engaged in local climate resilience efforts. Local health systems are in constant recovery mode as evidenced by the significant impact of the COVID-19 pandemic and critical barriers to local climate action include a lack of expertise, capacity, and sustained funding within the public health workforce. The proposed community-driven project seeks to integrate climate change impacts into a regional community health assessment framework to enhance the capacity of local health systems to identify, address, and monitor climate impacts on health in rural Appalachia.

PI_NAMEs: RUNKLE, JENNIFER D. (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Affordable Care Act;Appalachian Region;Awareness;Climate;climate change;climate crisis;climate data;climate impact;climate variability;climate zone;climate-related health;Collaborations;Communication;Communities;community burden;Community Health;Community Health Networks;community partners;County;COVID-19 pandemic effects;Data;data integration;design;Droughts;Environmental Health;Equity;Event;extreme weather;Fostering;Frequencies;Funding;Future;Generations;Goals;hazard;Health;health assessment;health communication;health data;health disparity;health inequalities;Health Personnel;Health Priorities;Health protection;Health system;Healthcare Systems;Heat Waves;Hospitals;Human;implementation strategy;improved;Infrastructure;Intervention;Joints;Knowledge;marginalized community;member;Modeling;Monitor;Needs Assessment;Outcome;pandemic disease;Pathway interactions;Persons;Phase;Planets;Play;Policies;population health;Precipitation;pressure;Process;Process Assessment;Public Health;Readiness;Recovery;Research;resilience;Risk;Rural;rural America;Rural Appalachia;rural area;Rural Community;Rural Health;Rural Population;rural underserved;Science;Scientist;social determinants;social disparities;social stressor;Strategic Planning;stressor;Structural Racism;Subgroup;Time;Training;Underserved Population;United States National Institutes of Health;Vision;Visual;Visualization;vulnerable community;weather patterns;Wildfire;Work

PROJECT_TITLE: Integrating Climate Impacts into a Community Health Assessment for Rural Communities

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project narrative Rising levels of antibiotic resistance in the bacteria as well as rising case numbers have created an urgent need to develop effective vaccines against Neisseria gonorrhoeae, and studies suggest that vaccines that contain bacterial outer membrane vesicles may provide partial protection against N. gonorrhoeae. A major protein antigen in outer membrane vesicles, PorB, has immune suppressive properties that may limit the immunogenicity of these vaccines. We propose to develop chemically inactivatable PorB proteins that can be used to generate outer membrane vesicles with improved immunogenicity.

PI_NAMEs: DUNCAN, JOSEPH A;NICHOLAS, ROBERT A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Ablation;Antibiotic Resistance;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antimicrobial Resistance;Bacteria;Biological;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Chemicals;Country;Crosslinker;Culture Media;Cysteine;cytokine;Data;Dendritic Cells;Development;Drug Metabolic Detoxication;Drug-resistant Neisseria Gonorrhoeae;Effectiveness;epidemiology study;Escherichia coli;Exhibits;experimental study;Failure;falls;Future;Genes;Genome;gonorrhea vaccine;Growth;Human;human pathogen;Immune;Immune Evasion;Immune response;Immune signaling;Immune system;Immunity;Immunization;Immunize;immunogenicity;immunoregulation;Immunosuppression;improved;Individual;Infection;Ions;Isopropyl Thiogalactoside;Label;Lipid Bilayers;Location;Mass Vaccinations;Measures;Mediating;Membrane;Membrane Proteins;Modification;Molecular Weight;mouse model;Mus;mutant;Mutate;Mutation;Natural Immunity;Neisseria;Neisseria gonorrhoeae;Neisseria meningitidis;novel;pathogen;Pathogenicity;Patients;PorB porin;Predisposition;Prevention strategy;promoter;Property;protective effect;protein function;Proteins;Protocols documentation;Public Health;Reagent;Recombinants;Reporting;Research;response;Role;Serogroup B Neisseria meningitidis;Structural Models;Swelling;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;tool;Vaccination;vaccine development;vaccine immunogenicity;Vaccines;vaginal infection;Variant;VDAC1 gene;Vesicle

PROJECT_TITLE: Modulation of immune responses mediated by PorB from Neisseria gonorrhoeae

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Networking and Information Technology R&D (NITRD);Palliative Care;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: The decision to perform a biventricular repair (BiVR) or a single ventricle palliative (SVP) in patients born with a  borderline left ventricle (BLV) remains challenging and subjective. We aim to develop a robust personalized  computational model capable of predicting the immediate postoperative outcomes of virtual BiVR and SVP with  confidence intervals and provide recommendations to choose the procedure that yields the most favorable  hemodynamics. Ultimately, this simulation-guided treatment planning will mitigate the risk of morbidity and  mortality and reinterventions in this critical population. Project Narrative

PI_NAMEs: KALFA, DAVID ;VEDULA, VIJAY  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Acceleration;Address;Adopted;Adult;Bayesian Analysis;Blood flow;candidate identification;Cardiac Catheterization Procedures;Cardiopulmonary Bypass;Cardiovascular system;Circulation;Classification;Clinical;Clinical Data;clinical decision-making;clinical translation;cohort;Common Ventricle;computer framework;Computer Models;Confidence Intervals;Data;Decision Making;dimension reduction;Echocardiography;Endocardial Fibroelastosis;Goals;Growth;Guidelines;Heart;hemodynamics;Hybrids;Hypoplastic Left Heart Syndrome;improved;Individual;innovation;Intervention;Left;Left ventricular structure;malformation;Markov chain Monte Carlo methodology;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;Morphology;mortality;neonate;network models;neural network;Operative Surgical Procedures;Outcome;palliation;palliative;Parameter Estimation;Pathway interactions;Patients;Physiology;Population;Postoperative Period;predictive modeling;Procedures;Pump;Recommendation;Rehabilitation therapy;repaired;restoration;risk mitigation;risk stratification;simulation;Structure;Testing;treatment planning;ultrasound;Uncertainty;Variant;Ventricular;virtual;Work

PROJECT_TITLE: Personalized Computational Modeling for Predicting Hemodynamics in Borderline Left Ventricles

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


PHR: Lassa virus causes thousands of cases of hemorrhagic fever each year in West Africa. Infection by Lassa virus is marked by pH-dependent conformational rearrangements of viral glycoprotein complex (GPC) that drive a switch from the receptor used at the cell surface to a subsequent receptor used in the endosome. In this project, we will interpret these GPC rearrangements and endosomal receptor engagement at the atomic level in order to provide the long-term missing knowledge of Lassa infection, as well as novel templates for antiviral design.

PI_NAMEs: LI, HAOYANG  (contact)

PROJECT_TERMS: Acids;Address;Adopted;Africa;Arenavirus;base;Binding;Binding Proteins;Biochemistry;Biological Assay;Cell Compartmentation;Cell surface;Cell-Matrix Junction;Cells;Cellular biology;Characteristics;Complex;conformational conversion;Cryoelectron Microscopy;design;Disease;Dissociation;emerging virus;Endocytosis;Endosomes;Engineering;epidemic preparedness;extracellular;global health;Glycoproteins;GP2 gene;GTPBP1 gene;Hemorrhage;human monoclonal antibodies;Image;Incubated;Individual;Infection;innovation;insight;Knowledge;Lassa;Lassa Fever;Lassa virus;Lujo virus;Lymphocytic choriomeningitis virus;Mediating;Medical;Membrane Fusion;Membrane Proteins;Modeling;Modification;Molecular Conformation;Monoclonal Antibodies;monomer;Morbidity - disease rate;mortality;novel;Old World Arenaviruses;Peptide Signal Sequences;Polysaccharides;prevent;Procedures;Process;programs;protonation;Public Health;receptor;receptor binding;Receptor Cell;Resolution;Risk;structural biology;Structure;Surface;tool;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Proteins;Virion;Virus;Virus Diseases;Western Africa;Work;World Health Organization;α-Dystroglycan

PROJECT_TITLE: Understanding pH-dependent receptor utilization of Lassa virus


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE  A substantial number of clinical studies have observed defects in mitochondria in Alzheimer’s disease (AD) patients as well as post-mortem patient samples, but research remains overwhelmingly needed to better understand the mechanisms underlying mitochondrial dysfunction in AD in order to reveal promising therapeutic targets. The proposed project will study the AD-associated ubiquitination of mitochondrial proteins by a E3 ubiquitin ligase Nedd4L using a familial AD mouse model. The goal is to establish Nedd4L as a contributor for mitochondrial dysfunction in AD and introduce future therapeutic approaches.

PI_NAMEs: TSAI, NIEN-PEI  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;Address;Affect;Alcohol dehydrogenase;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Antibodies;APP-PS1;Autopsy;Binding;Brain;Calcium;Cells;Clinical Research;Complex;Data;Defect;Development;Down-Regulation;Electron Transport;Electrophysiology (science);Energy Metabolism;Exhibits;familial Alzheimer disease;Functional disorder;Future;Genes;Goals;Health;imaging approach;Impaired cognition;Impairment;improved;in vivo;Knock-out;Link;Mediating;Membrane Potentials;Membrane Proteins;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Molecular;mouse model;Mus;Names;Nerve Degeneration;nerve stem cell;Neurons;novel;optogenetics;Outer Mitochondrial Membrane;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Peptides;Permeability;Phenotype;Phosphorylation;Production;Protein Dephosphorylation;Protein Isoforms;Proteins;Reactive Oxygen Species;Repression;Research;Respiration;Role;Sampling;Serine;Signal Pathway;System;Testing;Therapeutic;therapeutic target;Toxic effect;Transgenic Organisms;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health

PROJECT_TITLE: Ubiquitination of Mitochondrial Proteins in Alzheimer's Disease


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Genomic medicine is rapidly expanding in cancer care and altering how and when patients receive hereditary cancer genetic testing and genetic counseling, with fewer patients being seen for both pre- and post-test counseling with a genetic counselor. This project observationally investigates how the process and content of post-test genetic counseling for hereditary breast and ovarian cancer (HBOC) vary depending on whether posttest counseling was preceded by pre-test counseling by a genetic counselor, and whether differences in communication are associated with client outcomes (retention of key information, intention to inform at-risk relatives, efficacy for follow-up, satisfaction with communication quality, psychological health, and decisional regret). Understanding how communication affects client outcomes in post-test HBOC genetic counseling interactions (F99) is critical for developing practice and curriculum standards and designing targeted training interventions (KOO) poised to increase cancer prevention and control through effective genetic counseling.

PI_NAMEs: BROADBRIDGE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Affect;cancer care;Cancer Control;cancer genetics;Cancer Institute of New Jersey;cancer prevention;Caring;Client;Clinical;clinical care;Code;Communication;communication behavior;Counseling;Coupled;depressive symptoms;design;Educational Curriculum;Educational Intervention;Effectiveness;Eligibility Determination;Ensure;Environment;Evaluation;evidence base;Family member;follow-up;Genetic Counseling;genetic counselor;genetic testing;Genomic medicine;Goals;Health;health management;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Malignant Neoplasm;improved;Intention;Intervention;Malignant Neoplasms;meetings;Mental Health;Modeling;non-genetic;novel;Outcome;patient oriented;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;Persons;Phase;point of care;Postdoctoral Fellow;precision medicine;Process;Professional counselor;Provider;psychologic;Psychological adjustment;psychological outcomes;Qualifying;Quality of Care;Quality of life;Recommendation;reduce symptoms;Regrets;Relative Risks;Reporting;Research;Research Personnel;Risk;satisfaction;service delivery;Services;skills training;statistics;Students;Test Result;Testing;Therapeutic;therapy design;Training;Training Programs;Translational Research;United States;Well in self;Work

PROJECT_TITLE: Comparing post-test genetic counseling with and without pre-test counseling: The evolving landscape for optimizing cancer care

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Stuttering is a disorder of speech fluency that affects 3.5 million people in the USA alone. There is a great need  for increased efforts to translate recent discoveries from mechanistic neurophysiological studies into evidence based treatment options with potential for continuous optimization and personalization. The goal of this project  is to assess whether fluency enhancement with auditory feedback manipulations or with pharmacological agents  that regulate dopamine uptake improve the sensorimotor functions of speech feedback prediction and processing  in stuttering. Project Narrative

PI_NAMEs: HOUDE, JOHN FRANCIS;MAX, LUDO ;NAGARAJAN, SRIKANTAN S. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Achievement;Adult;Adult Stuttering;Affect;aripiprazole;Auditory;Auditory area;auditory feedback;Behavior;Behavior Therapy;Behavioral;Biological Assay;Brain;Central Nervous System;Child;Clinical;clinical effect;clinical practice;Clinical Trials;Data;design;Development;Disease;Dopamine;Dose;efficacious treatment;Emotional;Evidence based treatment;experience;experimental study;Feedback;Foundations;Future;Goals;improved;Individual;insight;Intervention;Laboratories;Life;Link;Literature;Magnetoencephalography;Mediating;Methods;Motor;Movement;Nature;neural;neurophysiology;neuroregulation;Neurosciences;novel;Outcome;Persons;Pharmaceutical Preparations;pharmacologic;Placebos;Process;Production;Public Health;Quality of life;Randomized;reduce symptoms;Relapse;Research;Research Design;self esteem;Sensorimotor functions;Sensory;sensory feedback;Social Well-Being;Speech;speech fluency disorder;Speech Sound;Stuttering;Symptoms;Testing;Translating;uptake;Work

PROJECT_TITLE: Dopamine and sensorimotor function in stuttering

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Obstructive Pulmonary Disease;Lung

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Our proposed implantable airway stents with integrated artificial cilia, overcome the limitation of existing airway stents such as tissue ingrowth or cilia impairment, and can allow minimally invasive removal of excessive mucus in the airway. It thus addresses the current limitation of existing airway stents in terms of excessive accumulation of mucus in patients with Central Airway Obstruction due to Chronic Obstructive Pulmonary Disease and other lung diseases. The proposed work thus could lead to novel implantable medical devices which can save lives and improve the quality of our life, with an eventual goal to shed light on new therapies for pulmonary diseases and other diseases related to cilia dysfunction.

PI_NAMEs: DONG, XIAOGUANG  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Academic Medical Centers;Address;airway obstruction;Animal Testing;Area;Biological;biomaterial compatibility;Biomedical Engineering;blind;Breathing;Bronchi;Bronchoscopes;Bronchoscopy;Cardiac Surgery procedures;Chronic Obstructive Pulmonary Disease;Cilia;Clinical;Clinical Trials;curative treatments;Cystic Fibrosis;design;Devices;Disease;disease model;Electromagnetics;Electronics;Engineering;Ensure;Excision;experience;experimental study;fabrication;Family suidae;flexibility;Frequencies;Functional disorder;Future;Goals;Growth;Home;Hospitals;Human;Human body;Hybrids;IACUC;Image;Impairment;Implant;improved;In Vitro;in vivo;Incidence;innovation;interest;Intervention;Invaded;Knowledge;Life;Link;Liquid substance;Lung;Lung Diseases;Lung Transplantation;magnetic field;Magnetism;Malignant neoplasm of lung;Mechanics;Medical Device;medical implant;Medicine;Metals;meter;Methods;Microfluidics;mid-career faculty;migration;millimeter;minimally invasive;Motion;Motor;Mucous body substance;multidisciplinary;novel;novel therapeutics;operation;Operative Surgical Procedures;Organ;Patients;Performance;portability;Prevalence;Process;professor;programs;Protocols documentation;pulmonary vascular disorder;Pulmonology;Pump;quantitative imaging;Reporting;Research;Research Personnel;Risk Reduction;Robotics;Safety;Silicones;stem;Stents;Suction;Surface;System;Technology;Testing;Thoracic Surgical Procedures;Time;Tissues;tomography;tool;Trachea;Translating;Transplant Surgeon;Transportation;Trauma;Universities;Validation;wearable device;wireless;Work

PROJECT_TITLE: Wirelessly Actuated Ciliary Stent for Minimally Invasive Treatment of Cilia Dysfunction


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Dental, Oral, and Craniofacial Disease;Physical Activity;Prevention

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Exercise represents one of the most beneficial things people can do to improve their health, but people often struggle to exercise enough to see the health benefits. In order to identify medications that provide some of the same benefits as exercise, this study will synergize two NIH Common Fund datasets (MoTrPAC and LINGS). By identifying biomolecular signatures of exercise from MoTrPAC and matching them to signatures of small molecules from LINGS, this study expects to identify multiple medicines that can be tested as exercise-in-a-pill.

PI_NAMEs: KNOWLES, JOSHUA WILEY (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Acceleration;Acute;Address;Adipose tissue;Adult;Aerobic Exercise;Area;Biological Models;Biology;Blood;Body System;Cataloging;Catalogs;Cell Physiology;cell type;Cells;Chronic;Chronic Disease;cloud based;Communities;computer infrastructure;cost;Data;Data Collection;data integration;data library;Data Set;data tools;Databases;design;Disease;drug candidate;Elements;Epigenetic Process;Exercise;exercise training;Exposure to;Funding;Future;Gene Cluster;Gene Expression;Gene Expression Profile;gene regulatory network;Gene set enrichment analysis;Genes;Health;Health Benefit;human data;improved;Infrastructure;innovation;insight;Insulin Resistance;Intervention;Knowledge;Libraries;Link;Maps;Medicine;meetings;metabolomics;mimetics;Molecular;Motivation;Multiomic Data;multiple omics;Muscle;Network-based;novel;Oral;Organism;Pain;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Physical activity;pill;programs;Proteomics;Rattus;Research;Research Personnel;resistance exercise;Resources;response;sex;skeletal tissue;small molecule;small molecule libraries;synergism;Testing;Time;Tissues;transcriptomics;Transducers;translational scientist;United States National Institutes of Health;Validity and Reliability;Vision;Visual;web app;young adult

PROJECT_TITLE: Synergizing Common Fund Data from MoTrPAC and LINCS for the Discovery of Novel Exercise Mimetic Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


PHR: Project Narrative Urethral disease and hypospadias are conditions that affect children and adults. When urethral replacement or  repair is required, alternative tissue options are limited and are associated with a high risk of short and long-term  complications. This proposal will create and test novel layered three dimensional (3D) bioprinted urethral tissue  patches with optimized mechanical and biological properties to effectively repair or replace urethral tissue.

PI_NAMEs: ANNABI, NASIM  (contact);STURM, RENEA

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adult;Affect;Animals;Binding Sites;Biocompatible Materials;bioink;Biological;biomaterial compatibility;Biomimetics;bioprinting;Bladder;Cardiovascular system;Cell Line;Cell Proliferation;Cells;Characteristics;Cheek structure;Child;clinical translation;Complex;Cues;Defect;design;Development;Disease;Diverticulum;efficacy evaluation;Elasticity;Elastin;elastomeric;Elastomers;Encapsulated;Engineering;Environment;Extracellular Matrix;Extracellular Matrix Proteins;Family suidae;Fistula;functional outcomes;Future;Goals;Growth Factor;high risk;Human;Hydrogels;Hypospadias;improved;In Vitro;in vivo;in vivo evaluation;Infection;innovation;Lower urinary tract;Lung;Malignant - descriptor;Malignant Neoplasms;mechanical properties;Mechanics;Methacrylates;Methods;migration;Modeling;Morbidity - disease rate;novel;Organ;Penile Erection;penis foreskin;preservation;prevent;Property;Proteins;Rattus;Recombinants;repaired;replacement tissue;Research;scaffold;seal;sealant;Secondary to;Shapes;Site;Skin;Smooth Muscle Myocytes;Source;standard of care;Structure;Techniques;Testing;Tissue constructs;Tissue Engineering;tissue regeneration;tissue repair;Tissues;translational applications;Trauma;Tropoelastin;Tubular formation;Urethra;Urethral Diseases;Urethral Stricture;Urinary tract;Urothelium;Vascularization;wound healing;wound vascularization

PROJECT_TITLE: Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]