ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Biotechnology;Chronic Pain;Clinical Research;Genetics;Neurosciences;Pain Research

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The underlying causes of low back pain are an enigma despite the huge socio-economic burden of this debilitating disorder, with current surgical interventions proving ineffective and highly invasive. The goal of this proposal is to establish the effects of non-viral delivery of developmental transcription factors using engineered extracellular vesicles to reprogram native diseased IVD cells from painful intervertebral discs in situ to a healthy biosynthetically active anti-nerve/vascular phenotype using clinically relevant animal models of back pain. Non- viral gene delivery with engineered extracellular vesicles is a novel concept for the treatment of discogenic back pain and there is a critical need to develop non-addictive treatments that target both the underlying cause of disease as well as pain to improve human health and quality of life.

PI_NAMEs: HIGUITA-CASTRO, NATALIA ;PURMESSUR (WALTER), DEVINA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Age;age effect;Animal Model;Animals;Award;Back Pain;Biological;Blood Vessels;Brachyury protein;Cell Survival;Cell Therapy;cell type;Cells;Chronic low back pain;clinically relevant;comparative;comparison control;Data;Development;discogenic pain;Disease;DNA;Drug Delivery Systems;Economic Burden;effective therapy;efficacious treatment;Engineering;Extracellular Matrix;Extracellular Matrix Proteins;extracellular vesicles;FOXF1 gene;Functional disorder;gene delivery system;Gene Expression;gene therapy;Goals;Growth;Health;Human;Hydration status;improved;In Situ;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Injury;innovation;Intervertebral disc structure;intervertebral disk degeneration;Ligands;Low Back Pain;Mechanics;Membrane;minimally invasive;Mission;Modeling;mouse model;Mus;Nerve;neurotrophic factor;non-viral gene delivery;novel;nucleus pulposus;Operative Surgical Procedures;opioid epidemic;opioid use;Pain;pain behavior;pain reduction;pain symptom;Pathologic;Pathology;Patients;Phenotype;phenotypic biomarker;programs;protein expression;Proteomics;Publishing;Quality of life;Research;Role;scleraxis;sex;socioeconomics;Specificity;Structure;success;symptom treatment;targeted delivery;targeted treatment;Therapeutic;Therapeutic Intervention;Tissues;tool;transcription factor;treatment strategy;United States National Institutes of Health;uptake;Vertebral column;Viral;Vision;Work

PROJECT_TITLE: Novel non-viral reprogramming strategies to treat Discogenic back pain via engineered extracellular vesicles

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: PEARSON, MELANIE ALICE (contact)

PROJECT_TERMS: Achievement;Address;Advocate;Affect;Area;Awareness;Back;Budgets;Cities;Clinic;Collaborations;Communication;Communities;community collaboration;community engaged research;community engagement;Community Health;community partners;community planning;Complex;Consultations;Core Facility;Data;Data Science;Data Science Core;Educational workshop;Ensure;Environmental Health;environmental justice;Equity;Evaluation;Excision;Federal Government;Funding;Goals;Government Agencies;Grant;Health;Health Sciences;Human;improved;Industrialization;Knowledge;Language;Laws;Learning;learning engagement;Local Government;meetings;member;Mission;Modeling;Movement;National Institute of Environmental Health Sciences;Neighborhoods;Nonprofit Organizations;Outcome;Personal Satisfaction;Phase;Pilot Projects;Play;Process;programs;remediation;Reporting;Research;Research Activity;Research Support;Resources;Role;Science;Scientist;Services;Site;State Government;Structure;Students;success;Superfund;superfund site;Training;Translating;Translational Research;Trust;Universities;usability;Vision;Work

PROJECT_TITLE: HERCULES: Exposome Research Center


NIH_SPENDING_CATS: Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: ANDERSON, KIM A. (contact)

PROJECT_TERMS: adverse outcome;Analytical Chemistry;analytical method;Aromatic Polycyclic Hydrocarbons;Assessment tool;Biological;Biological Availability;Chemical Exposure;Chemicals;Collaborations;Communities;community engagement;Community Health;community organizations;community partners;Complement;Consultations;consumer product;Core Facility;cost;Data;data visualization;Devices;Diagnosis;Disease;disorder prevention;Disparity population;Endocrine Disruptors;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Evaluation;experience;Exposure to;Faculty;Flame Retardants;Foundations;Frequencies;Health;Health Personnel;health science research;Health Sciences;Human;Human Biology;improved;Industrialization;Infrastructure;innovation;Intervention;Investments;Learning;Link;Manufacturer;Measures;member;Metals;Methodology;Methods;Mission;Modeling;Monitor;novel;Organic Chemicals;Pacific Northwest;Participant;Pathway interactions;Persons;Pesticides;Pharmacologic Substance;phthalates;Polychlorinated Biphenyls;Population;prospective;Protocols documentation;Public Health;Research;Research Personnel;Resources;Sampling;Scientist;Services;Silicones;Techniques;Technology;Toxic Environmental Substances;Toxicology;volatile organic compound;Volatilization;wristband

PROJECT_TITLE: Chemical Exposure Facility Core

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: MORGAN, EDWARD THOMAS (contact)

PROJECT_TERMS: Achievement;Affect;Applications Grants;Area;Award;career;career development;Clinical Research;Collaborations;Communication;Communities;community engaged research;community engagement;community partners;Core Facility;Data;Data Science Core;Development;Ear;early-career faculty;empowerment;Ensure;Environmental Health;Evaluation;experience;Fostering;Funding;Grant;Growth;Health;Health Sciences;Human;improved;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Leadership;Learning;member;Mentors;Mission;National Institute of Environmental Health Sciences;NIH Program Announcements;North Carolina;Personal Satisfaction;Pilot Projects;Policies;Politics;Process;programs;Public Health;Publications;remediation;Request for Proposals;Research;Research Personnel;Research Project Grants;Resources;Schools;Services;Sister;Strategic Planning;Study Section;success;synergism;Techniques;Technology;Time;Translational Research;Translations;United States National Institutes of Health;Universities;Vision;Work;Writing


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The computational principles and neural architecture supporting complex and naturalistic navigation are unknown. In the current project I will elucidate these mechanisms by performing large-scale neurophysiology and introducing ambiguities during path integration in virtual reality; rodents will be required parse optic flow signals into self- and externally-generated components, and will be submitted to multisensory illusions altering their subjective self-location. The knowledge gained from this proposal will inform our understanding of the mechanism underlying disorders of inference, such as Autism and Schizophrenia.

PI_NAMEs: NOEL, JEAN-PAUL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Accounting;Adaptive Behaviors;Animals;Architecture;Area;autism spectrum disorder;Award;Behavior;Behavioral;Belief;Biological;Biological Psychiatry;Brain;career;career development;Cells;Code;Cognition;Cognitive;Cognitive Science;Communication;Complement;Complex;Coupling;cranium;Darkness;Data Collection;Data Science;design;Development Plans;Disease;Disparity;Environment;experience;Feedback;Fireflies;Foundations;Genetic Variation;Goals;Grant;Health;Hippocampal Formation;Hippocampus;Human;Human Resources;Illusions;Institution;International;Knowledge;Link;Location;Maps;Measures;Mediating;member;Mentors;Modeling;Motion;Motor;mouse model;Movement;multisensory;Mus;neglect;neural;neural circuit;Neurons;neurophysiology;Neurosciences;nonhuman primate;novel;novel therapeutics;object motion;optic flow;Personal Space;Phase;phenomenological models;Photons;Physiology;place fields;Positioning Attribute;preference;Prize;Process;receptive field;Research;Retina;Rodent;Rodent Model;Schizophrenia;Scientist;Sensory;Signal Transduction;skills;System;Techniques;Technology;Testing;Training;virtual;virtual reality;Visual Motion;visual motor;way finding;Work;Writing

PROJECT_TITLE: Neural and Computational Architecture for Complex Navigation and Subjective Self-Location

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Clinical Research;Prevention

PI_NAMEs: KILE, MOLLY L (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Area;Award;Awareness;Budgets;career;career development;Collaborations;Communication;Communities;Core Facility;Coupling;Data;data to knowledge;Discipline;Disease;Environment;Environmental Exposure;Environmental Health;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Health;health science research;health science research support;Human Biology;improved;Individual;innovation;interdisciplinary collaboration;Intervention;Investments;Knowledge;Manufacturer;member;Mentors;Methodology;Mission;National Institute of Environmental Health Sciences;Outcome;Pacific Northwest;Pharmacologic Substance;Pilot Projects;Play;Population;prevent;Prevention strategy;Probability;Process;programs;Public Health;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Risk Reduction;Role;Science;Scientist;Services;Source;Strategic Planning;success;theories;Time;Translational Research;Translations;Tribes;Writing

PROJECT_TITLE: Pilot Projects Program


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE This project will investigate the neural representation of sequence monitoring, a process that is necessary for daily life. Currently, the neural underpinnings of sequence monitoring remain unknown. A systematic explication of the neural circuitry underlying structured sequence viewing could lead to new treatments for diseases and disorders where sequential behaviors are disrupted, such as obsessive-compulsive disorder.

PI_NAMEs: DESROCHERS, THERESA MARIE (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Activities of Daily Living;Adaptive Behaviors;Anatomy;Area;Back;Basal Ganglia;Behavior;Behavior monitoring;Behavioral;behavioral study;Brain;Cells;Cerebellum;Code;Cognitive;Complex;Computer Models;Data;Disease;Dissociation;Electrophysiology (science);Elements;experimental study;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Human;Knowledge;Lateral;Life;Location;Medial;medial temporal lobe;member;Memory;Monitor;Monkeys;Motor;Motor Cortex;Motor output;neglect;neural;neural circuit;neuromechanism;Neurons;neurophysiology;nonhuman primate;Obsessive-Compulsive Disorder;Organism;Patients;Pattern;Play;Population;Positioning Attribute;Prefrontal Cortex;Primates;Process;programs;Reporting;Research;Resolution;Rodent;Role;sequence learning;Series;Signal Transduction;Structure;Testing;Training;visual information;Work

PROJECT_TITLE: Testing neural mechanisms of sequence monitoring in the frontal cortex across species: integrated fMRI and electrophysiology

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative The main goal of our project is to improve our understanding of the genetic basis of human- specific phenotypes. This may eventually lead to deeper knowledge of the origins and etiologies of human-specific diseases such as epithelial cancers, acne, autism, schizophrenia, and Alzheimer’s disease.

PI_NAMEs: FRASER, HUNTER B (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: 3-Dimensional;Acne;Adipose tissue;Affect;Alleles;Alzheimer's Disease;ATAC-seq;autism spectrum disorder;Biology;Candidate Disease Gene;candidate identification;Carcinoma;Cardiac Myocytes;Cartilage;Cell Differentiation process;Cell fusion;Cell Line;cell type;Cells;Chromatin;Chromosomes;CRISPR/Cas technology;Data;Dermis;Disease;Environment;enzyme activity;Epidermis;Ethics;Etiology;Evolution;experience;Exposure to;fetal;Ganglia;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genome Mappings;genome-wide;Genomic Imprinting;Goals;Hair follicle structure;Hamsters;Hepatocyte;High-Throughput RNA Sequencing;Human;Human Genome;Hybrid Cells;hybrid gene;Hybrids;improved;In Vitro;in vitro Model;induced pluripotent stem cell;interest;Knowledge;Maps;Measurement;Methods;Modeling;Motor Neurons;Mus;Muscle Fibers;Natural Selections;Organism;Organoids;Pan Genus;Pancreas;Pathway interactions;Phenotype;Play;Primates;progenitor;Radiation Hybrid Map;Radiation Hybrid Mapping;Rana;Regulation;Research;Resources;Rodent;Role;Salmo trutta;Sampling;Schizophrenia;Skeletal Muscle;Skin;Structure of retinal pigment epithelium;System;Testing;three dimensional cell culture;trait;Trans-Activators;transcription factor;transcriptome sequencing;unethical;X Inactivation

PROJECT_TITLE: Investigating human cis-regulatory evolution with hybrid iPS cells

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Creating Access to Resources and Economic Support  (The CARES Study) Project Narrative Gender minorities are particularly vulnerable to COVID-19 pandemic-related economic and mental health harms. This health disparities population needs effective, sustainable, community- led interventions that address their unique needs. The goal of this study is to test the efficacy of a microgrant intervention with or without peer mentoring to reduce psychological distress and promote COVID-19 risk reduction behaviors.

PI_NAMEs: POTEAT, TONIA C (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adult;Advocacy;Alcohol abuse;arm;Automobile Driving;Award;Behavior;Behavioral;Black race;cohort;Communities;community led intervention;community organizations;community partnership;community-level factor;comparative efficacy;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevention;COVID-19 risk;COVID-19 susceptibility;Data;design;Disadvantaged;economic impact;Economics;Education;effective intervention;efficacy evaluation;efficacy testing;Emergency Situation;Employment;Enrollment;Ensure;Equity;experience;Feeling suicidal;financial literacy;Financial Support;food insecurity;Future;gender minority;General Population;Goals;Hand;Health;Health Benefit;health disparity;health disparity populations;health inequalities;Hour;Housing;Individual;Inequity;innovation;Intervention;intervention participants;Interview;Masks;Mediating;Mental Health;Methods;minority stress;minority stressor;Online Systems;pandemic disease;pandemic stress;Participant;peer coaching;peer support;Persons;polysubstance use;Population;Poverty;pre-pandemic;Process Measure;prospective;Prostitution;psychologic;psychological distress;Psychological Impact;psychosocial;Randomized;Randomized, Controlled Trials;recruit;relative effectiveness;Reporting;Resources;response;Risk Reduction Behavior;Safety;Science;social;social stigma;stress symptom;stressor;structural determinants;Surveys;Testing;Text;Text Messaging;transgender;transgender men;transgender women;Translating;traumatic stress;treatment arm;treatment as usual;Treatment Efficacy;Underserved Population;Unemployment;United States National Institutes of Health;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Creating Access to Resources and Economic Support (CARES)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: QUEENSLAND

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: GRIFFITH UNIVERSITY

PHR: PROJECT NARRATIVE Trauma and/or inflammation as mechanisms cannot fully account for the different HIV transmission rates in the presence of specific genital microbes. We have recently shown that HIV glycan shield double-up as an attachment factor via a novel ‘non-electrostatic and specific’ oligomannose (oligoman)-based interaction, offering a general mechanism to account for the opposite HIV transmission phenotypes seen in the presence of lactobacillus vs sexual transmission infection bacteria, such as Neisseria gonorrhoeae. This project will determine whether this manipulatable oligoman-based interaction has: (i) helped trapped HIV onto lactobacillus to reduce HIV transmission; and (ii) allowed HIV to hijack Neisseria gonorrhoeae to gain access into the host.

PI_NAMEs: MAK, JOHNSON  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Bacteria;Bacterial Infections;Bacterial Vaginosis;Binding;Biological Models;Biology;biophysical analysis;biophysical techniques;CCR5 gene;CD4 Antigens;cell killing;Cell surface;Cells;Cervical;cervicovaginal;Clinical;clinically relevant;cohort;Cytometry;Data;Dendritic Cells;Development;Electron Microscopy;Electrostatics;Epithelial Cells;Epithelium;Eukaryotic Cell;Exhibits;follow-up;Genetic;Genitalia;Glycoconjugates;Glycoside Hydrolases;glycosylation;HIV;HIV envelope protein;HIV Infections;HIV Receptors;Human;Image;Imaging Techniques;Immune;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Invaded;Laboratories;Lactobacillus;Langerhans cell;Language;Lectin;Life;Liquid substance;Male Circumcision;Mannose;Mannose Binding Lectin;mass spectrometric imaging;Mediating;Microbe;Microbial Biofilms;Modeling;Molecular;Molecular Cloning;Molecular Virology;Monosaccharides;Movement;nanoluciferase;Neisseria gonorrhoeae;neutrophil;novel;Nutraceutical;Oral;Outcome;particle;pathogenic virus;penile microbiome;Phenotype;Polysaccharides;Population;preference;Process;Production;receptor;Recombinants;Reporter;Resource-limited setting;Risk;Risk Reduction;Role;Route;Services;sexual HIV transmission;Sexual Transmission;Sexually Transmitted Diseases;sialoadhesin;South African;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;sugar;Surface;Surface Plasmon Resonance;T-Lymphocyte;Techniques;Tight Junctions;Time;tissue culture;transmission process;Trauma;Urethra;Vagina;Vaginal Douching;vaginal lactobacilli;vaginal microbiome;Viral;Virus

PROJECT_TITLE: Dichotomy of HIV-Sugar with Vaginal Microbes

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is focused on elucidating the psychosocial and biological pathways through which structural racism and discrimination adversely affect chronic musculoskeletal pain and associated disability in older Black or African American adults. Chronic musculoskeletal disorders are the leading cause of pain and disability worldwide, and older Black adults bear a disproportionate burden of musculoskeletal pain. Therefore, this work has the potential to inform broadly applicable strategies for reducing health disparities.

PI_NAMEs: LOSIN, ELIZABETH R;TERRY, ELLEN L. (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: accelerated epigenetic aging;Adult;Adverse effects;Affect;African American;African American population;Area;Biological;Biological Process;biopsychosocial;Black American;Black Populations;Black race;Brain;brain circuitry;Buffers;Chronic;Chronic disabling pain;chronic musculoskeletal pain;chronic pain;chronic painful condition;clinical pain;Communities;Data;deprivation;disability;Disadvantaged;Discrimination;DNA Methylation;epigenetic aging;Epigenetic Process;Ethnic Origin;experience;Food;Frequencies;Health;improved;indexing;Individual;innovation;Intervention;knee pain;Knowledge;marginalized population;Measures;Mediating;Mediator;Modeling;Movement;Musculoskeletal Diseases;Musculoskeletal Pain;neighborhood disadvantage;Neighborhoods;neurobiological mechanism;Neurobiology;Not Hispanic or Latino;novel;older adult;optimism;Pain;pain catastrophizing;Pain interference;pain outcome;pain-related disability;Pathway interactions;perceived discrimination;perceived stress;Personal Satisfaction;Physical Function;Political Systems;Process;psychosocial;psychosocial outcome;psychosocial stressors;Race;racial minority population;racial population;racism;Reduce health disparities;Reporting;Research;residential segregation;resilience;resilience factor;Sampling;Severities;skin color;social;social cohesion;Social support;Societies;socioeconomic disadvantage;Socioeconomic Status;statistics;Structural Racism;Testing;Underserved Population;United States;Work

PROJECT_TITLE: The impact of structural racism and discrimination on chronic pain in Black or African American older adults: Biopsychosocial mechanisms

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Encinitas

ORG_NAME: AIVOCODE, LLP

PHR: PROJECT NARRATIVE The goal of this proposal is to complete pharmacology studies and generate the requisite preclinical data package and regulatory dossiers to support the clinical development of a novel neuroprotective peptide as a treatment for moderate to severe traumatic brain injury. Our neuroprotective peptide specifically targets injured brain and reduces the secondary injury after the primary impact. This project addresses an underserved medical area, where there is a pressing need for new therapeutic advances.

PI_NAMEs: MANN, AMAN  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Address;Air;Animals;Anti-Inflammatory Agents;Area;axonal pathfinding;Bacteriophages;base;Behavior;Binding;Binding Proteins;Biological Availability;Biological Markers;Brain;Brain Death;Brain Injuries;central nervous system injury;Chemistry;Clinical;clinical development;Clinical Trials;Closed head injuries;Collaborations;Communication;Consultations;Contusions;Data;Department of Defense;Development;Dose;drug development;Drug Kinetics;efficacy study;experimental study;Family suidae;Financial Hardship;first-in-human;Formulation;Frequencies;Future;Genetic Markers;Genetic Transcription;Goals;Guidelines;healing;Histology;Histopathology;Hour;Human;Image;imaging biomarker;improved;in vivo;Injectable;Injury;innovation;Intervention;Investigation;Investigational Drugs;Laboratory Markers;Lead;Lesion;Libraries;manufacture;Medically Underserved Area;Miniature Swine;Modeling;mouse model;myelination;National Institute of Neurological Disorders and Stroke;Nature;Neurologic;neuroprotection;Neuroprotective Agents;novel;novel therapeutic intervention;novel therapeutics;Penetration;peptide drug;Peptides;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology Study;Phase;Physiological;Plasma;Play;porcine model;pre-clinical;pre-Investigational New Drug meeting;preclinical development;preclinical study;primary outcome;Process;Property;Proteins;Rattus;Recovery;Recovery of Function;research clinical testing;response;Rodent;Rodent Model;Role;Safety;safety study;screening;secondary outcome;Severities;Side;Site;Sprague-Dawley Rats;Synaptic plasticity;TBI Patients;TBI treatment;Tenascin;Testing;Therapeutic Agents;therapeutic candidate;Therapeutic Studies;Time;tissue injury;Tissues;Toxic effect;Toxicokinetics;Toxicology;Translations;Trauma;Traumatic Brain Injury;Treatment Efficacy;United States Food and Drug Administration

PROJECT_TITLE: Development of a novel peptide therapeutic for traumatic brain injury


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE: This proposal evaluates the role of Fcγ receptors not only in CARD9-CLR signaling but also in antibody-mediated uptake and killing of Pneumocystis by macrophages. Specifically, this proposal will evaluate the combined activities of both innate (CLR-CARD9 axis) and adaptive immunity components through their common reliance on the shared Fcγ receptors and how activation of host cells through these pathways provide additive benefits crucial for proper host immunity. We will further use these observations to develop novel therapeutic approaches targeting these pathways for PCP, for those who are refractory or fail standard antibiotic therapy.

PI_NAMEs: LIMPER, ANDREW H (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Ablation;Acquired Immunodeficiency Syndrome;adaptive immunity;Address;Adjuvant;Adjuvant Therapy;Adrenal Cortex Hormones;alveolar bone;Alveolar Macrophages;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;Bone Marrow;C Type Lectin Receptors;CD4 Positive T Lymphocytes;Cells;co-infection;cytokine;dectin 1;Epithelium;experience;Fc Immunoglobulins;Fc Receptor;Generations;IgG Receptors;Immune response;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;improved outcome;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Intervention;ITAM;Kinetics;lung injury;Macrophage;Mediating;Morbidity - disease rate;mortality;mouse dectin-2;mouse model;Mus;Myeloid Cells;Natural Immunity;novel;novel strategies;novel therapeutic intervention;Organism;Pathway interactions;Patients;Phenotype;Pneumocystis;Pneumocystis carinii Pneumonia;Pulmonary Inflammation;receptor;Receptor Signaling;Refractory;Respiratory Failure;response;Role;Serum;Signal Transduction;small molecule inhibitor;Testing;treatment strategy;uptake

PROJECT_TITLE: Pneumocystis: Macrophage & Epithelial Activation

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Racial and Ethnic Minority Health Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SUGAR LAND

ORG_NAME: ASCLEPIA TECHNOLOGY LLC

ORG_STATE: TX

PHR: Atherosclerosis, a chronic inflammatory arterial disease, builds plaques in the inner part of arterial wall, leading to vessel lumen narrowing and blood clotting, consequently to two life-threatening conditions, heart attack and stroke. Minority patients exhibit an increased prevalence of advanced atherosclerotic arterial disease, and they need cellular therapy with blood vessel-specialized stem cells for repair and regeneration of their diseased arterial wall. This project will employ an innovative technology to generate nanoparticle- targeted stem cells to repair the arterial wall with advanced atherosclerosis or atheroma.

PI_NAMEs: GENG, YONG JIAN (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: 3-Dimensional;Acute myocardial infarction;Adherence;Adipose tissue;Affinity;Animal Model;Antibodies;Area;Arterial Fatty Streak;Arteries;Asclepias;Atherosclerosis;Binding;Biological Assay;Biological Models;Black race;Blood Banks;Blood coagulation;Blood Vessels;Bone Marrow;Cardiac;Cardiovascular Agents;cardiovascular health;Cause of Death;Cell Culture System;cell injury;cell preparation;Cell Therapy;Cells;cellular targeting;Cerebrovascular Disorders;Cessation of life;Chronic;cigarette smoking;Clinical;Clinical Research;Collaborations;Contrast Media;controlled release;cytokine;Cytoprotection;Data;Development;Devices;Diabetes Mellitus;disability;Disease;disease model;drug development;Economic Burden;Economics;Emergency Situation;Endothelial Cells;Endothelium;Epigenetic Process;ethnic minority;Ethnic Population;Exhibits;experimental study;Exposure to;Extracellular Matrix;Functional disorder;Gases;Generations;Goals;good laboratory practice;Growth;Health;health disparity;Hispanic;Human;Immunoglobulin G;Immunoliposome;immunoreactivity;In Vitro;in vivo;Incidence;Incubated;Inflammation;Inflammatory;injured;innovation;innovative technologies;Intercellular adhesion molecule 1;Investigational Drugs;Ischemic Stroke;Label;Lesion;Life;Lipids;Liposomes;Low-Density Lipoproteins;manufacture;MCAM gene;Mechanical Stress;Microgravity;Microgravity Simulation;migration;Minority;Minority Groups;minority patient;molecular imaging;Mus;Myocardial Infarction;Myocardial Ischemia;nanoparticle;Natural regeneration;Not Hispanic or Latino;Obesity;Operative Surgical Procedures;Organ;Organoids;oxidized low density lipoprotein;Pathogenicity;Patients;Perfusion;peripheral blood;Persons;Pharmacologic Substance;Phase;phase 1 study;preclinical study;Prevalence;Procedures;Proliferating;prototype;quality assurance;Quality Control;repaired;Research;Research Personnel;Risk Factors;Rupture;Safety;Small Business Innovation Research Grant;social;socioeconomic disadvantage;stability testing;stem cell delivery;stem cell growth;stem cell therapy;stem cells;Stroke;success;Surface;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;thrombogenesis;Thrombosis;Translations;Ultrasonography;ultrasound;United States;Universities;Validation;Variant;Vascular Diseases

PROJECT_TITLE: Development of targeted cellular therapy for atherosclerotic vascular disease in minority patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (A1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Over 7 million Americans currently suffer from a neurodegenerative disease (NDD). Although age is the greatest known risk factor for the onset of NDDs, we urgently need to understand the mechanisms by which treatable risk factors contribute to disease, including sleep and circadian clock disruption. In this proposal, we will investigate the likely bidirectional relationship between circadian desynchronization and NDD progression.

PI_NAMEs: KARATSOREOS, ILIA NICHOLAS;WOERMAN, AMANDA L. (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;Address;Age;alpha synuclein;Alzheimer's Disease;American;Animal Model;Autophagocytosis;Biological Rhythm;Brain;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Dementia;Disease;Disease Progression;epidemiology study;experience;experimental study;Feedback;Future;Goals;Hour;Impairment;Individual;Intervention;Knowledge;Literature;Measures;Mediating;Methods;Modeling;Molecular;Molecular Conformation;mouse model;Multiple System Atrophy;Nature;Neurodegenerative Disorders;novel;Onset of illness;Pathogenicity;Pathologic;Patients;poor sleep;Positioning Attribute;pre-clinical;prion-like;protein aggregation;protein misfolding;Proteins;Regulation;Research;Risk Factors;Role;shift work;Signal Pathway;Sirolimus;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;small molecule;Sorting;Symptoms;tau mutation;tau Proteins;time use;Time-restricted feeding;United States National Institutes of Health;Work

PROJECT_TITLE: Untangling the bidirectional relationship between the spread of pathological protein aggregates, sleep, and circadian clock disruption in neurodegenerative disease

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Contact PD/PI: HALPERN, SCOTT PROJECT NARRATIVE The University of Pennsylvania Patient-Oriented Research and Training to Accelerate Learning (Penn PORTAL) will develop new learning health system (LHS) Scientists and conduct state-of-the-art research to build LHS capacity. With three integrated cores, an equity and community engagement unit, and governmental, community, and health system partnerships across Philadelphia, this program will achieve the ideals of an LHS in which each patient encounter is informed by prior patient encounters, and all encounters contribute to equitable outcomes.

PI_NAMEs: DELGADO, MUCIO ;HALPERN, SCOTT D (contact);LANE-FALL, MEGHAN BROOKS

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PI_NAMEs: HALPERN, SCOTT D (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: WERNER, RACHEL M (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: JOHNSON, KEVIN B. (contact)

PROJECT_TITLE: Research Data and Analysis Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: The pathologic accumulation of misfolded α-synuclein (α-syn) in neurons leads to neurodegeneration and cognitive dysfunction and dementia in a family of disorders designated α-synucleinopathies, which includes Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) dementia (PDD). The project objectives are to understand the actions of Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN) also known as MIF in pathologic α-syn induced cognitive dysfunction and determine whether a first in class, MIF nuclease inhibitor is protective in models of pathologic α-syn induced cognitive dysfunction. In addition the role of pathologic α-syn in activating cGas and STING pathway and subsequent inflammasome activation via PAAN/MIF nuclease activity will be explored. These finding could offer innovative therapeutic approaches to treat pathologic α-syn induced cognitive dysfunction.

PI_NAMEs: DAWSON, TED M.;DAWSON, VALINA L. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adenosine Monophosphate;alpha synuclein;Apoptosis;apoptosis inducing factor;Behavioral;Brain;Cell Death;cell type;Cessation of life;Characteristics;Clinical;Cognitive;Cyclic GMP;Cytosol;Dementia;Dementia with Lewy Bodies;Development;Disease;disease model;dopaminergic neuron;ds-DNA;Family;Female;Gene Activation;Genomic DNA;Impaired cognition;Inflammasome;inhibitor;innovation;Investigation;Knock-in Mouse;Length;male;Microglia;Mitochondrial DNA;Modeling;Mus;Nerve Degeneration;neurobehavior;Neurons;neuropathology;neuroprotection;nuclease;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathologic;Pathway interactions;Play;Poly Adenosine Diphosphate Ribose;Polymerase;prevent;response;Role;sensor;Source;Stimulator of Interferon Genes;synuclein;synucleinopathy;Testing;Therapeutic;Transferase

PROJECT_TITLE: MIF Nuclease actions in Synuclein Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Gallatin

ORG_NAME: PEDIADOSE LLC

ORG_STATE: TN

PHR: PROJECT NARRATIVE Errors in the administration of children’s medication at home disproportionally affects multiple NIH-designated health disparity populations, including low socioeconomic status and minority populations. We are developing a novel smart phone application which will improve medication safety at home through evidence-based digital innovations that target root causes of medication dosing errors. By creating higher quality of care through expanded access to medical information and improved health literacy, we aim to lessen childhood inequities and the impact they have in adulthood.

PI_NAMEs: CURRLIN, TUZDY  (contact)

PROGRAM_OFFICER_NAME: SIDHU, SIMRANN KAUR

PROJECT_TERMS: Academy;Accident and Emergency department;Address;Adult;Affect;age group;aged;American;Businesses;Caregivers;Cellular Phone;Child;Child Health;Childhood;commercialization;Confusion;conventional dosing;Custom;Data;design;Development;digital;digital health;disparity reduction;Dose;dose information;Drug Prescriptions;Ensure;ethnic diversity;evidence base;experience;Feedback;Funding;Goals;Health;health disparity populations;health inequalities;health literacy;high risk;Home;Hospitalization;Hospitals;Human;human centered design;Image;improved;Incidence;Individual;Inequity;innovation;Institution;Intuition;Knowledge;Label;Language;Lead;Life;Life Cycle Stages;Limited English Proficiency;low health literacy;low socioeconomic status;mathematical ability;Medical;Medical Device;medication administration;Medication Errors;Medication Management;medication safety;meetings;Minority;Minority Groups;mobile application;modifiable risk;novel;novel strategies;Outcome;overdose risk;Parents;Pathway interactions;Pediatrics;Pharmaceutical Preparations;Phase;Policies;Population;Population Heterogeneity;Preparation;Process;prototype;Quality of Care;Race;Reduce health disparities;Research;research clinical testing;Risk Factors;Safety;safety testing;smartphone application;Socioeconomic Status;software development;Spanish;Symptoms;Time;tool;Translations;United States National Institutes of Health;Update;usability;Validation;Work

PROJECT_TITLE: Novel Mobile Application to Reduce Health Disparities by Improving Dosing Accuracy of Children's Medication


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The brain is very vulnerable to metabolic problems and synapses, the machinery that mediates the conversion of electrical information into chemical information, are very sensitive to metabolic imbalances. Since neurodegenerative diseases results in improper function of synapses, we hypothesize that these disease states might have at their origin an imbalance between fuel availability and fuel use at the level of individual synapses. The fuel here that matters is a molecule called ATP and our work aims to understand how it is produced at synapses, who consumes it and how in diseases like Parkinson’s and Alzheimer’s this changes.

PI_NAMEs: RYAN, TIMOTHY AIDAN (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Acute;Address;adenovirus mediated delivery;adenylate kinase;Alzheimer's Disease;Bioenergetics;Biological;Blood Glucose;Brain;Brain region;Cell membrane;Cells;Chemicals;Clinical;Clinical Data;Collaborations;Coma;Consumption;Delirium;Dendrites;design;Disease;Drops;Energy consumption;enzyme activity;Enzymes;Failure;Functional disorder;Glucose;Glycogen;Glycolysis;Heart;Hereditary Spastic Paraplegia;Human;Impairment;improved;in vivo;Individual;insight;Intellectual functioning disability;Ion Pumps;Knowledge;Lipase;Lipids;Mediating;Memory;Metabolic;Metabolism;Molecular;Mus;Mutation;Nerve;Nerve Degeneration;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurologic Symptoms;Neuromodulator;neuronal cell body;Neurons;neuropsychiatric disorder;Onset of illness;Outer Mitochondrial Membrane;oxidation;PARK7 gene;Parkinson Disease;Performance;Phosphoglycerate Kinase;Physiology;presynaptic;Presynaptic Terminals;Production;programs;protective effect;Recycling;Reporter;Research;Research Personnel;response;Role;Short-Term Memory;Signal Transduction;small hairpin RNA;Speed;Surface;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Testing;Time;Tissues;Triglycerides;Up-Regulation;Vesicle;Withdrawal;Work

PROJECT_TITLE: Physiology of Single Synaptic CNS Terminals

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Pediatric;Physical Rehabilitation;Rare Diseases;Rehabilitation

PHR: Project Narrative Ankle contracture, or loss of full ankle joint motion, commonly occurs alongside progression of muscle degeneration and weakness in ambulatory children with Duchenne muscular dystrophy (DMD). A lack of understanding of the pathophysiology of contracture development has limited the impact of rehabilitation interventions used to prevent contractures and maximize functional ability in DMD. This study will evaluate the potential mechanisms leading to loss of ankle range of motion and the muscle and tendon tissue adaptations associated with ankle contractures in ambulatory children with DMD, which will give rehabilitation professionals the ability to make more evidence-based decisions and provide more targeted interventions.

PI_NAMEs: BARNARD, ALISON M (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: achilles tendon;Activities of Daily Living;Adoption;Affect;Ankle;ankle joint;ankle joint dorsiflexor;arm;Articular Range of Motion;Automobile Driving;Biological Markers;Biomechanics;Breathing;Caregivers;Cerebral Palsy;Child;Chronic;Compensation;Complex;Connective Tissue;Contracture;Data;Degenerative Disorder;design;Development;Disease;Distal;Duchenne muscular dystrophy;effective intervention;Elbow;evidence base;Extensor;Fatty acid glycerol esters;flexibility;Flexor;Functional disorder;functional improvement;Gait;Genetic Diseases;Goals;Hand;Hip region structure;imaging approach;improved;Individual;Intervention;Joints;Knee;Knowledge;Leg;Length;Link;Lower Extremity;Magnetic Resonance Imaging;Measures;Motion;Muscle;muscle degeneration;muscle stiffness;muscle strength;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;physical therapist;Positioning Attribute;preservation;prevent;Prevention;prospective;Quality of life;Rehabilitation therapy;rehabilitative care;response;Stretching;symposium;Tendon structure;Testing;Time;Tissues;Toes;United States National Institutes of Health;Walking;walking rehabilitation

PROJECT_TITLE: Ankle contractures in muscular dystrophy: mechanisms and tissue adaptations

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (57)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Multiple sclerosis is an autoimmune, demyelinating, and degenerative disease characterized by lesions in the central nervous system that cause debilitating neurologic dysfunction. This proposed research will investigate a newly described mechanism by which neurons and oligodendrocytes within the central nervous system degenerate in the context of multiple sclerosis. Therefore, this work could establish new disease-modifying therapeutic advancements that halt the disease’s pathology without relying on immunosuppressants that are often temporarily beneficial, nonspecific, and ineffective for patients with progressive multiple sclerosis.

PI_NAMEs: MACE, JACKSON  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Acute;Affect;Age Years;alpha synuclein;Atrophic;Autoimmune Diseases;Autopsy;Axon;axon injury;Biological Models;Brain;Caspase;Cell Death;Cell Death Process;cell type;Cells;Central Nervous System;Cessation of life;Chronic;Chronic Disease;Circulation;Clinical;CNS degeneration;cohort;Complex;cytokine;Data;Degenerative Disorder;Demyelinating Diseases;Demyelinations;design;Development;differential expression;disability;Disabling;Disease;DNA Damage;dopaminergic neuron;Enzymes;Experimental Autoimmune Encephalomyelitis;experimental study;Exposure to;Functional disorder;Genetic;glial activation;Gliosis;Granzyme;gray matter;Immune;immune cell infiltrate;Immune system;Immunosuppressive Agents;Impairment;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;innovation;insight;Lesion;Lumbar spinal cord structure;Lymphocyte;Mediating;migration;Migration Inhibitory Factor;Modeling;Molecular;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Mus;Myelin;Myelin Sheath;Neonatal;neonatal exposure;neonatal mice;Nerve Degeneration;Nervous System Disorder;Neurologic;Neurologic Dysfunctions;neuron loss;Neurons;neuroprotection;novel;novel therapeutics;nuclease;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Oral;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Plasma;Play;Point Mutation;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;precursor cell;prevent;Process;programs;Relapsing-Remitting Multiple Sclerosis;Research;Retina;Retinal Ganglion Cells;Role;Serum;Severity of illness;single nucleus RNA-sequencing;Spinal Cord;Symptoms;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic target;therapy development;Time;Tissues;tool;trafficking;transcriptomics;Treatment Efficacy;United States;Variant;Veins;white matter;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Inhibition of MIF nuclease-mediated parthanatos prevents neuron and oligodendrocyte death in the context of multiple sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Boston Health Equity & community-Aligned Learning Health System (Boston HEALHS) e-STAR proposal builds upon existing Learning Health System resources and training programs to train scientists to tackle refractory problems of health disparities within a safety net system. The organizational infrastructure stimulated with the award will provide the scaffolding upon which to build a robust, sustainable Learning Health System that trains a new generation of diverse, methodologically rigorous, clinically embedded, and community- engaged scientists to design more effective, efficient, and equitable health systems.

PI_NAMEs: BAIR-MERRITT, MEGAN H;FISCHER, MICHAEL A. (contact)

PROJECT_TITLE: Boston Health Equity & community-Aligned Learning Health System (Boston-HEALHS)


PI_NAMEs: FISCHER, MICHAEL A. (contact)

PROJECT_TITLE: Administrative Core (AC)


PI_NAMEs: DRAINONI, MARI-LYNN  (contact)

PROJECT_TITLE: Research Education Core (REC)


PI_NAMEs: ADAMS, WILLIAM G (contact)

PROJECT_TITLE: Research and Data Analysis Core (RDAC)


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Individuals with profound anemia, particularly sickle cell anemia (SCA), have a high risk of developing strokes and silent cerebral infarcts; this risk begins in early childhood, with more than 50% affected by 30 years of age. Better understanding stroke mechanisms in anemia should improve stroke risk identification, and lead to better treatments to prevent stroke. This study uses multiple hemodynamic and metabolic brain imaging techniques to understand differences in brain blood flow and oxygen use before versus after anemia treatments, as well as how brain blood flow and oxygen utilization differ in anemic individuals with versus without strokes.

PI_NAMEs: DONAHUE, MANUS J (contact);JORDAN, LORI CHAFFIN

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Aftercare;Age;Age Years;Alzheimer's Disease;Anemia;arterial spin labeling;Benefits and Risks;Biological Markers;biomarker development;Blood;Blood capillaries;Blood Transfusion;Blood Vessels;Brain;brain health;Brain imaging;Cephalic;cerebral autoregulation;cerebral capillary;Cerebral Infarction;Cerebral Ischemia;Cerebrovascular Circulation;Cerebrum;Child;Clinical;clinically relevant;cohort;Compensation;Data;Disease;early childhood;Enrollment;Exclusion;Functional disorder;Genetic;Goals;Health;hemodynamics;Hemoglobin;Hemoglobin concentration result;high risk;Hyperemia;Hypertension;Image;imaging approach;Imaging Techniques;improved;in vivo;Individual;Infarction;innovation;intracranial artery;Ischemia;Ischemic Stroke;Magnetic Resonance Imaging;Measures;Metabolic;Metabolism;Methods;Migraine;Nervous System Trauma;neuroimaging;neurovascular;non-invasive imaging;novel;novel therapeutics;Outcome;Oxygen;Oxygen Consumption;Participant;Patients;Physiologic arteriovenous anastomosis;Physiology;Prevention therapy;Procedures;public health relevance;Publishing;Race;Regression Analysis;Reporting;Reproducibility;Risk;Risk Factors;Scanning;Severity of illness;sex;Sickle Cell Anemia;Signal Transduction;Sinus;stem cell therapy;Stenosis;Stroke;Stroke prevention;stroke risk;Testing;Therapeutic Trials;Time;Tissues;tool;Transfusion;Traumatic Brain Injury;treatment response;Triage;Vascular Diseases;Venous;venous sinus;Work

PROJECT_TITLE: Mechanisms of cerebral infarcts and brain oxygen utilization in anemia

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: POISERA, INC.

ORG_STATE: MI

PHR: 1 PUBLIC HEALTH RELEVANCE STATEMENT 2 Maternal mortality rates are three times higher among non-Hispanic Black than White women. SDoH are 3 social, economic, and environmental conditions that have been found to mediate between racial and ethnic 4 health disparities in maternal mortality, yet no standard of care exists for how and when to screen for health- 5 related social needs in pregnancy, let alone address them. In this SBIR, BetterHope LLC (dba Poisera) will 6 develop chatbot technology to identify and address SDoH for half a million Black pregnant women annually to 7 ultimately reduce the inequitable rates of maternal morbidity and mortality. 8

PI_NAMEs: KERPPOLA, MARIANNA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accountability;Address;application programming interface;behavioral health;Black race;black women;Cardiovascular system;chatbot;Child Rearing;commercial application;Community Health;cultural competence;Data;Death Rate;design;Development;Disclosure;Disparity;disparity reduction;early pregnancy;Economics;Employment;Enrollment;ethnic health disparity;Ethnic Origin;experience;Financial Hardship;follow-up;food insecurity;Fright;Health;health disparity;Health Technology;Hospitals;housing instability;Human;Individual;Inequity;Infant;Infant Mortality;innovation;insight;Intellectual Property;Interpersonal Violence;Intervention;Interview;Judgment;Knowledge;Licensing;Low Birth Weight Infant;Marketing;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;Medicaid;Mental Health;minority health;minority health disparity;mobile application;Mobile Health Application;Monitor;Mood Disorders;Morbidity - disease rate;mortality;Mothers;Not Hispanic or Latino;novel;Outcome;Participant;Patients;Personal Satisfaction;Phase;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Premature Birth;Prenatal care;Professional counselor;programs;prototype;Psychosocial Stress;public health relevance;Race;racial health disparity;Randomized, Controlled Trials;Reporting;Resources;Rights;Risk;Risk Factors;Risk Reduction;screening;Screening procedure;Services;Small Business Innovation Research Grant;social;social determinants;social health determinants;social stigma;Social support;standard of care;Strategic Planning;Stress;Surveys;technological innovation;Technology;Testing;Transportation;treatment risk;United States Centers for Medicare and Medicaid Services;usability;Validation;White Women;Woman

PROJECT_TITLE: Identifying and Addressing Social Determinants of Health in Pregnant Women


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PEDSnet Scholars: A National Pediatric Learning Health System Embedded Scientist Training and Research Program NARRATIVE Creating integrated learning health systems (LHSs) that improve child health will require a new generation of pediatric scientists with diverse backgrounds who will be embedded in healthcare organizations’ clinical and research operations. We propose to address this need by creating a Pediatric LHS Embedded Scientist Training and Research Center. The Center will be integrated within PEDSnet, a PCORnet Clinical Research Network and a national pediatric LHS with 11 institutional members that provide care for 10% of the nation’s children.

PI_NAMEs: CHISOLM, DEENA ;FORREST, CHRISTOPHER B (contact);GOLDMANN, DONALD ALAN


PI_NAMEs: FORREST, CHRISTOPHER B (contact)

PROJECT_TITLE: Admin Core (use for Administrative Core)


PI_NAMEs: GOLDMANN, DONALD ALAN (contact)

PROJECT_TITLE: Res Ed Core (use for Research Education Core)


PROJECT_TITLE: Res and Data Analysis Core (use for Research and Data Analysis Core)


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE: OVERALL The Learning Health systems training to improve Disability and chronic condition care (LeaHD) center will train embedded scientists to conduct PCOR/CER and dissemination and implementation research that will inform improvements in health system operations and quality of care. LeaHD will train a cadre of learning health systems (LHS) scientists who will be poised to transform the delivery, quality, and outcomes of care for persons with disability and chronic conditions by focusing on rehabilitation and long term services and supports (LTSS). LeaHD will build upon a well-established infrastructure and collaborative relationships between Brown University, University of Pittsburgh, and Boston University, extensive faculty expertise, and established and emerging partnerships with a diverse group of nine health system partners.

PI_NAMEs: RESNIK, LINDA J. (contact)


PROJECT_TITLE: Learning Health systems training to improve Disability and chronic condition care (LeaHD) Administrative Core


PI_NAMEs: SHIREMAN, THERESA I. (contact)

PROJECT_TITLE: Learning Health systems training to improve Disability and chronic condition care (LeaHD) Research Education Core


PI_NAMEs: FREBURGER, JANET KUES (contact)

PROJECT_TITLE: Learning Health systems training to improve Disability and chronic condition care (LeaHD) Research and Data Analysis Core


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The University of Pittsburgh TraCe MPS Center’s (Pitt-TraCe) qualified, patient-derived, structured, biomimetic liver Microphysiology Systems (MPS) platform will deliver qualified DDTs that will dramatically improve the efficiency and accuracy in liver safety and efficacy for drug development decisions, especially for complex heterogeneous diseases in precision medicine. These commercially available, qualified DDTs will benefit the drug development process for the pharmaceutical industry and FDA regulatory oversight. In addition, the Automated Biomimetic Analytic MPS (ABAMPS) platform employing commercially available materials from can be harnessed to qualify new organ structured, biomimetic MPS in the future.

PI_NAMEs: MIEDEL, MARK T.;SCHURDAK, MARK E (contact);SOTO-GUTIERREZ, ALEJANDRO ;TAYLOR, D. LANSING;VERNETTI, LAWRENCE A

PROGRAM_OFFICER_NAME: KREPKIY, DMITRIY

PROJECT_TERMS: Acceleration;Address;Automation;Back;Biomimetics;Biotechnology;cell type;Cells;Cellular biology;Clinic;Clinical Trials;cohort;Collaborations;commercialization;Communication;Complement;Complex;Computational Biology;Computer Models;Critical Pathways;Data;Decision Making;Development;Disease;drug development;drug discovery;drug efficacy;Drug Industry;drug metabolism;drug testing;efficacy testing;Ensure;Environment;Exhibits;experience;Fatty Liver;Future;Genetic;Goals;Hepatic;hepatic acinus structure;Hepatocyte;Hepatotoxicity;Heterogeneity;Human Resources;Immune;improved;Individual;induced pluripotent stem cell;Informatics;innovation;Life Style;Liver;Medical center;meetings;microphysiology system;Molecular Biology;Names;National Center for Advancing Translational Sciences;non-alcoholic fatty liver disease;Obesity;Organ;organizational structure;participant enrollment;Patients;Pharmacologic Substance;Physiological;Population;precision medicine;Procedures;Process;programs;Progressive Disease;Protocols documentation;Qualifying;Quality Control;Reagent;Reporting;Research Design;Resources;Role;Safety;safety testing;Science;Source;spatial relationship;statistics;Structure;Systems Biology;Technology;technology platform;tool;tool development;Toxic effect;translational applications;United States Food and Drug Administration;Universities;Work

PROJECT_TITLE: Qualification of Patient-Derived Biomimetic Liver MPS as Drug Discovery Tools for Drug Metabolism, Toxicity, Drug Efficacy Testing and Clinical Trial Cohort Selection

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 TC-9 (01)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Patient Safety;Precision Medicine

PI_NAMEs: SOTO-GUTIERREZ, ALEJANDRO  (contact)

PROJECT_TERMS: Acceleration;Administrator;Automation;Biochemical;Biomimetics;Biotechnology;Budgets;Clinical;clinical care;Clinical Trials;cohort;Collaborations;commercialization;Communication;Communities;companion diagnostics;Complex;Computational Biology;Computer Models;Data Set;data sharing;Decision Making;Development;Disease;Disease Progression;drug development;drug discovery;drug efficacy;Drug Industry;drug metabolism;drug testing;Education;efficacy testing;empowerment;Ensure;Environment;experience;Faculty;Feedback;Fostering;Foundations;Goals;Government Agencies;Grant;health care delivery;Hepatic;Hepatotoxicity;Human;improved;Industry;Infrastructure;innovation;Innovative Therapy;Institution;Leadership;Liver;Medical center;meetings;member;microphysiology system;Mission;Molecular;National Center for Advancing Translational Sciences;non-alcoholic fatty liver disease;novel strategies;novel therapeutics;operation;Outcome;Patients;Pharmacologic Substance;Precision therapeutics;Procedures;Process;Productivity;program dissemination;Qualifying;Regulation;Reporting;Research;Resources;Role;safety testing;Schedule;Science;Scientist;Seasons;stem cells;Structure;success;Systems Biology;Technology;technology development;Therapeutic;three dimensional cell culture;tool;tool development;Toxic effect;Translational Research;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Networking and Information Technology R&D (NITRD);Patient Safety

PI_NAMEs: VERNETTI, LAWRENCE A (contact)

PROJECT_TERMS: Advisory Committees;Automation;Back;Biological Sciences;Biomimetics;Cells;Cellular biology;Clinic;Clinical;Clinical Trials;cohort;Collaborations;commercialization;Computational Biology;Computer Models;Data;Devices;drug development;drug discovery;drug efficacy;drug metabolism;drug testing;efficacy testing;Ensure;Fatty Liver;Future;Goals;Hepatic;induced pluripotent stem cell;Informatics;Liver;Measurement;Medical center;Metadata;microphysiology system;Molecular Biology;Names;non-alcoholic fatty liver disease;Obesity;Organ;Patients;Positioning Attribute;Preparation;Procedures;Production;Protocols documentation;Qualifying;Quality Control;Reagent;Reproducibility;Research Design;Resource Sharing;Resources;safety testing;Sampling;scale up;Source;statistics;Structure;Systems Biology;technology platform;tool;tool development;Toxic effect;Toxicology;Universities;Validation;Work

PROJECT_TITLE: MPS Resources Section


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Patient Safety;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SCHURDAK, MARK E (contact)

PROJECT_TERMS: Animal Testing;Area;Automation;Back;Binding;Biomimetics;Blood Vessels;Cells;Clinic;Clinical;clinical diagnosis;Clinical Trials;Clinical Trials Design;cohort;Collecting Cell;Collection;Complex;Computer Models;Critical Pathways;Data;data platform;Development;Disease;Dose;drug candidate;drug development;drug discovery;drug efficacy;drug metabolism;drug testing;Drug toxicity;efficacy testing;Endothelial Cells;Environment;experience;falls;Fatty Liver;Fibrosis;first-in-human;Genetic;Hepatic;hepatic acinus structure;Hepatocyte;Hepatotoxicity;Heterogeneity;Human;human disease;Image;Immune;improved;Incubated;individual patient;individualized medicine;induced pluripotent stem cell;Infiltration;Inflammation;Injections;innovation;Kupffer Cells;Life Style;Liver;Liver diseases;Measurement;Measures;Medical center;meetings;Metabolic Clearance Rate;Microfluidic Microchips;National Center for Advancing Translational Sciences;non-alcoholic fatty liver disease;Obesity;Outcome;Parameter Estimation;Parents;participant enrollment;Patients;Pharmaceutical Preparations;Polymers;precision medicine;predicting response;Process;programs;Protocols documentation;Qualifying;Reproducibility;Research Design;Role;Safety;safety testing;Science;screening;stellate cell;Structure;System;Technology;Testing;Texas;Tissue Microarray;tool;tool development;Toxic effect;trial design;Universities;Validation;Vascularization

PROJECT_TITLE: MPS Qualification Section


ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our LHS STAR NJ program will train future scientists and health professionals in the best ways to evaluate and improve the quality, outcomes, and patient-centeredness of care through educational classes, mentoring, and hands on learning. It makes available to a broad community all of the research knowledge and resources needed to do projects that will improve health and health equity. Our program combines the teaching and research knowhow of Rutgers Biomedical and Health Sciences (7 health professions schools) partnered with a 6 diverse health system partners, insurers, and government agencies.

PI_NAMEs: HALM, ETHAN A;HUDSON, SHAWNA V. (contact)

PROJECT_TITLE: Learning Health System Scientist Training And Research in New Jersey (LHS STAR NJ)


PI_NAMEs: PANETTIERI, REYNOLD ALEXANDER (contact)


PI_NAMEs: JIMENEZ, MANUEL E (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: GERHARD, TOBIAS  (contact)

PROJECT_TITLE: Research and Data Analysis Core


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Overall Project Narrative The overarching goal of the Massachusetts Institute for Equity-Focused Learning Health System Science (MIELHSS) is to train embedded health system scientists and accelerate the conduct of equity-focused PCOR/CER to improve health system operations, quality, and health outcomes. Our group includes several large academic health systems, FQHCs, community centers, safety net hospitals, PCORnet sites, and the VA; together we care for diverse populations and share a common goal to advance equity-focused learning health system science. Our proposed infrastructure will: 1) create a stimulating environment to develop embedded LHS scientists from diverse backgrounds, 2) build a robust shared data structure that will support and accelerate equity-focused research, and 3) accelerate the collaborative culture change that will be needed to drive meaningful impact in LHS and health equity.

PI_NAMEs: GUISE, JEANNE-MARIE  (contact)


PHR: Administrative Core Narrative The Administrative Core of the Massachusetts Institute for Equity-focused Learning Health System Science (MIELHSS) coordinates and manages all Institute activities across its Research Education and Research Data Cores. The role of the Administrative Core is to: 1) Provide leadership, direction, and oversight of MIELHSS; 2) Foster internal and external communications and engagement across health systems, community and stakeholder partners, scholars, mentors, projects, and cores to create a broad and sustained culture of integrated E-LHS science; and 3) Advance E-LHS research methods through a methods incubator. We will measure success using metrics such as grant submissions and publications while also by measuring health system engagement in MIELHSS activities and sustained implementation and widespread adoption of equity-focused interventions and health system improvements.

PROJECT_TITLE: MIELHSS - Admin Core


PHR: Education Core Narrative The Education Core works with the Administrative and Data Cores, and Heath system and community partners to train embedded health system scientists and accelerate the conduct of equity-focused PCOR/CER to improve health system operations, quality, and health outcomes. Our educational infrastructure will: 1) create a stimulating environment to develop embedded LHS scientists from diverse backgrounds, 2) provide a novel intensive program of embedded research training featuring Human-Centered Design, and 3) provide meaningful experiential mentored learning in diverse settings.

PROJECT_TITLE: MIELHSS - Research Education Core


PHR: Research Data Core Narrative The Research Data Core (RDC) for the Massachusetts Institute for Equity-focused Learning Health System Science (MIELHSS) aims to support ongoing equity-focused research for and beyond the scholars by developing common data standards, shared practices, and an infrastructure for conducting distributed data analysis and data sharing across the MIELHSS organizations. We provide ongoing mentorship of MIELHSS scholars, assisting scholars in accessing and interpreting PCORnet, Medicare, Medicaid, and other research datasets, and we work in concert with the Administrative Core on dissemination strategies.

PROJECT_TITLE: MIELHSS - Data Core


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Disparities in healthcare quality and outcomes persist and a systematic approach is needed to reorient and restructure healthcare systems to address this urgent problem. The Columbia-Cornell-Einstein EQUIP+ Center for Learning Health System (LHS) Science will provide a novel training and research program that leverages cross-institutional collaborations to develop a diverse cadre of embedded LHS Scientists who are equipped to improve healthcare delivery and outcomes. EQUIP+ Center LHS Scientists will generate and disseminate evidence through this dynamic infrastructure to advance the equity, quality, and safety of healthcare for all.

PI_NAMEs: ADELMAN, JASON STUART (contact);ALCANTARA, CARMELA ;MASTERSON CREBER, RUTH MARIE;MOISE, NATHALIE

PROJECT_TITLE: Columbia-Cornell-Einstein EQUIP+ Center for Learning Health System Science


PI_NAMEs: ADELMAN, JASON STUART (contact)


PI_NAMEs: MOISE, NATHALIE  (contact)


PI_NAMEs: MASTERSON CREBER, RUTH MARIE (contact)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE This research project aims to understand the molecular mechanisms leading to the demise of neurons in Alzheimer's disease (AD) brains and identify potential therapeutic targets and biomarkers. By studying select AD pathology-associated proteins and their impact on disease progression, non-amyloid pathways mediated by these proteins, and the biochemical mechanisms by which they regulate assembly of Aβ filaments, this project seeks to inform the development of more effective experimental models and therapeutic and imaging agents for AD. The ultimate goal is to enhance public health by improving our fundamental knowledge of AD pathogenesis and finding new ways to lengthen life, reduce illness, and minimize disability caused by this devastating disease.

PI_NAMEs: PENG, JUNMIN ;YU, GANG  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: abeta toxicity;Aducanumab;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid formation;amyloid pathology;Amyloid Proteins;Antibodies;Apolipoprotein E;beta amyloid pathology;Binding;Biochemical;Biochemical Pathway;Biochemistry;Biology;Brain;Clinical;Code;cognitive benefits;Collaborations;Complex;computerized data processing;Cryoelectron Microscopy;Data;Deposition;Detergents;Development;disability;Disease;disease phenotype;Disease Progression;Experimental Models;Family;Filament;genome editing;Goals;Human;human tissue;imaging agent;improved;In Vitro;in vivo;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Label;large scale data;laser capture microdissection;Life;Light;Link;Maps;Mass Spectrum Analysis;Mediating;midkine;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Neurons;neuroproteomics;novel;NTN1 gene;Pathogenesis;Pathologic;Pathway interactions;Pharmaceutical Preparations;pleiotrophin;Protein Family;Proteins;Proteome;Proteomics;Public Health;reconstitution;recruit;Research Project Grants;resilience;Resolution;Resources;response;restraint;Role;Sampling;screening;skills;structural biology;Structure;success;Symptoms;System;Systems Biology;Testing;Therapeutic Agents;Therapeutic antibodies;therapeutic biomarker;therapeutic target;tool;Toxic effect;validation studies

PROJECT_TITLE: Systems Approaches to Novel Molecular Mechanism in Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public Health Relevance Statement To address the growing need for mHealth scientists who can integrate diverse scientific approaches and work in transdisciplinary teams, the UCLA mHealth Institutes will provide an innovative training program that will offer the didactic and team science experiences essential for solving complex behavioral health problems.

PI_NAMEs: SHETTY, VIVEK  (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Active Learning;addiction;Addictive Behavior;Address;advanced analytics;Age;analytical method;Articulation;behavior change;Behavioral;behavioral health;career;Collaborations;collaboratory;Communication;Community Health;Competence;Complex;Computer software;Data Collection;Dedications;design;Development;Devices;digital;digital health;digital platform;digital technology;Discipline;Ecosystem;Education;education resources;Effectiveness;effectiveness evaluation;Elements;Ensure;Evaluation;experience;Explosion;Faculty;Fostering;Geography;Graph;handheld mobile device;Health behavior change;Healthcare;Home;Hybrids;Imagination;improved;Individual;Information Sciences;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;Interpersonal Relations;Intervention;Knowledge;Life Style;Link;Logic;Methodology;mHealth methodology;mobile computing;Modeling;multidisciplinary;network models;next generation;novel;Palpable;Participant;Pathway Analysis;Pattern;Persons;Positioning Attribute;Process;process improvement;programs;public health relevance;Publications;Research;Research Personnel;Resources;Schools;Science;Scientific Advances and Accomplishments;Scientist;Social Network;Substance Addiction;success;Techniques;theories;Thinking;tool;Trainers Training;Training;Training Programs;Translations;United States National Institutes of Health;virtual;Vocabulary;web site;Work

PROJECT_TITLE: Training Institutes for mobile health (mHealth) methodologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-R (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: Carson

ORG_NAME: SAFEBEAT RX INC.

PHR: PROJECT NARRATIVE Over 38 million people worldwide suffer from atrial fibrillation, but access to heart rhythm drugs is restricted by the required three-day hospitalization to start these oral medications due to rare, dangerous rhythm side effects. The objective of this SBIR is to expand access to these life-saving medications, which are currently underprescribed to minority and rural populations due to the required hospitalization. The proposed research will advance technology created by SafeBeat Rx to allow atrial fibrillation patients to start medications safely at home via automated mobile heart rhythm analysis.

PI_NAMEs: GERSTENFELD, EDWARD PAUL;NAVARA, RACHITA  (contact);PATEL, KUNJ G.

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Address;Admission activity;Affect;Age;Agreement;Algorithms;Anti-Arrhythmia Agents;Atrial Fibrillation;automated algorithm;barrier to care;Bluetooth;Cardiac;Cardiovascular system;Caring;Clinical;cloud based;commercial application;Communities;Computer software;Computers;cost;Cost Savings;Dangerousness;Data;Decision Making;Defibrillators;design;Devices;Diagnosis;Disease;Disparity;Dose;Electric Countershock;Electrocardiogram;Electronic Health Record;FDA approved;Future;Goals;Guidelines;health care disparity;Health Disparities Research;heart rhythm;Home;hospital care;Hospitalization;Hospitals;Human;human study;improved;innovation;Inpatients;Insurance Carriers;Knowledge;Label;Lead;Letters;Licensing;Life;Machine Learning;machine learning algorithm;Manuals;Manufacturer;Marketing;Measurement;Measures;Medical;Minority;Minority Groups;minority patient;mobile application;Monitor;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;novel;Oral;Outcome;Outpatients;Palpitations;patient population;patient subsets;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians;Population;prospective;Provider;Quality of life;Recommendation;reduce symptoms;Regulatory Pathway;remote patient monitoring;Research;response;Risk;Rural;Rural Community;Rural Minority;Rural Population;Safety;satisfaction;Secure;side effect;Small Business Innovation Research Grant;standard of care;Stroke;Surveys;System;Target Populations;Technology;Telemetry;Telephone;Testing;Time;Titrations;tool;Training;transmission process;Underserved Population;usability;validation studies;wearable device;web portal

PROJECT_TITLE: Novel, automated mobile heart rhythm analysis technology to start antiarrhythmic medications safely at home


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WILMINGTON

ORG_NAME: GLAX, LLC

ORG_STATE: DE

PHR: Project Narrative The goal of this Fast-Track project is to develop chemotherapy in which the newly discovered SATB2 inhibitor in our laboratory inhibits higher HCC growth in AA, compared to CA, using clinically relevant cancer cell lines, and patient-derived tumor (PDX) model established from HCC tissues derived from AA and CA patients, resulting in eliminating HCC disparities in AA.

PI_NAMEs: SRIVASTAVA, RAKESH K. (contact)

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Affect;African American;African American population;Alcohol abuse;alcohol exposure;Artificial Intelligence;beta catenin;Binding;Binding Proteins;Biological;Brain;Cancer cell line;Cancer Etiology;cancer stem cell;caucasian American;cell growth;Cell Line;Cessation of life;chemotherapy;chromatin remodeling;Chronic;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data;design;Development;differential expression;Disease;Disparity;Disparity population;Docking;Dose;Drug Kinetics;Economics;Environment;Etiology;Exhibits;experience;exposed human population;FDA approved;Gene Expression;Generations;Genes;Genetic;Goals;Growth;Health;health disparity;Hepatocyte;In Vitro;in vivo;Incidence;Individual;Induction of Apoptosis;inflammatory milieu;inhibitor;inhibitor therapy;insight;Intestines;Kidney;Laboratories;Legal patent;Liver;liver injury;Malignant - descriptor;Malignant Epithelial Cell;Marketing;Minority Groups;Modeling;Molecular;molecular dynamics;mortality;mouse model;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Nuclear Matrix-Associated Proteins;Oncogenic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;pluripotency;Preventive;Primary carcinoma of the liver cells;Proteins;racial disparity;Reactive Oxygen Species;Regulator Genes;Sampling;self-renewal;stem cell biomarkers;Stimulus;Stress;Techniques;Testing;Therapeutic;Tissues;Toxic effect;tumor;tumor growth;Tumor Tissue;Underserved Population;Work;Xenograft procedure

PROJECT_TITLE: Elimination Racial Disparities in Hepatocellular Carcinoma


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Asthma is a disease of the airways that is growing in prevalence and represents a major public health burden. In the majority of people with asthma, IgE antibodies play a role in triggering allergic immune responses in the lung that contribute to disease pathogenesis. In this project, we will study how IgE responses to aeroallergens are initially generated, resulting in allergic sensitization.

PI_NAMEs: ALLEN, CHRISTOPHER DAVID CABALLERO (contact)

PROGRAM_OFFICER_NAME: LIN, ADORA ASHELY

PROJECT_TERMS: Affect;airborne allergen;Airway Disease;airway obstruction;Allergens;Allergic;allergic airway disease;Allergic inflammation;Antibodies;Asthma;B-Lymphocytes;Binding;Blocking Antibodies;Cell secretion;Cells;Clinical Research;Complex Mixtures;Detection;Disease;Exposure to;Flow Cytometry;Generations;Goals;Grain;Human;IgE;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Stimulation;Immunologics;improved;Individual;Inhalation;insight;Laboratories;Learning;Ligation;Lung;Lung Diseases;Methodology;Microscopy;Modeling;Molds;mouse model;Mus;omalizumab;particle;Pathogenesis;Pathogenicity;Pathway interactions;Persons;plasma cell differentiation;Plasma Cells;Pollen;Population;Prevalence;prevent;Procedures;Process;Production;Public Health;pyroglyphid;receptor;Regulation;Reporter;Reproduction spores;Respiratory System;response;Role;Sampling;Specificity;Stains;Tissues;Xolair

PROJECT_TITLE: Regulation of IgE production during aeroallergen sensitization

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Overall Project Narrative: Southwest Safety Net Embedded Scientist Training and Research (SSNE-STaR) Center Arizona State University College of Health Solutions (ASU CHS) and Valleywise Health (VH) System will create the Southwest Safety Net Embedded Scientist Training and Research (SSNE-STaR) Center. Our goal is to help improve the health equity of historically disadvantaged populations, with a strong commitment to addressing the needs of Native American, Hispanic, homeless, and other underserved populations. We will support the scientific training and professional development of Scholars embedded across Arizona Safety Net Organizations (SNOs) to conduct comparative effectiveness and patient-centered outcome research (CER/PCOR) and gain proficiency in rapid-cycle implementation.

PI_NAMEs: RILEY, WILLIAM J. (contact);WHITE, MICHAEL


PI_NAMEs: RILEY, WILLIAM J. (contact)

PROJECT_TITLE: ADMIN CORE


PI_NAMEs: OHRI-VACHASPATI, PUNAM  (contact)

PROJECT_TITLE: REC


PI_NAMEs: DOMINO, MARISA ELENA (contact)

PROJECT_TITLE: RDAC


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Obesity

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Although hundreds of genes have been associated with coronary artery disease (CAD) and insulin resistance related metabolic traits, the lack of mechanisms linking CAD to insulin resistance has hampered development of new therapies. This study will determine the role of the gene PRDM16 (PR domain containing 16), which is at the intersection of both CAD and insulin resistance, on smooth muscle cell function and atherosclerosis using novel conditional knockout mouse models in conjunction with cutting edge genomic sequencing approaches. By determining the role of PRDM16 in smooth muscle cell function and atherosclerosis, this work will not only determine the mechanistic connection between PRDM16 and CAD but will also identify novel mechanistic connections between CAD and insulin resistance.

PI_NAMEs: PALMISANO, BRIAN T. (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adipose tissue;Affect;Atherosclerosis;atherosclerosis risk;Bioinformatics;Blood Vessels;career development;causal variant;Cause of Death;cell dedifferentiation;Cell Lineage;Cell Physiology;Cell Proliferation;Cellular biology;Chromatin;Clinical;conditional knockout;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;Development;Disease Resistance;disorder risk;Dyslipidemias;Epigenetic Process;epigenetic regulation;fasting glucose;Foundations;gene discovery;Gene Expression;gene network;gene regulatory network;Genes;Genetic;genomic locus;Genomics;Glucose;Glycosylated hemoglobin A;Goals;histone methyltransferase;Human;Hypertension;In Vitro;in vivo;Inflammatory;inflammatory marker;Informatics;insight;Insulin;Insulin Resistance;knock-down;Knockout Mice;Laboratories;Link;Lipids;MADH3 gene;Measures;Metabolic;Metabolic syndrome;Metabolism;migration;Molecular;Molecular Biology;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Physicians;Plasma;Play;prevent;Proliferating;Regulation;Resolution;response;Risk;Risk Factors;Role;Scientist;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;SKI gene;skills;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;Techniques;Technology;Testing;therapy development;Tissues;trait;Transcriptional Regulation;transcriptome;translational genetics;Vascular Smooth Muscle;Vascular Smooth Muscle Tissue;Waist-Hip Ratio;Work

PROJECT_TITLE: The Epigenetic Regulator Prdm16 Controls Smooth Muscle Phenotypic Modulation and Atherosclerosis Risk


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Fibroblasts are cells that maintain the structural framework of most tissues, and many studies show that they can also promote and suppress tissue inflammation. This project will study how fibroblasts in rheumatoid arthritis develop the ability to suppress joint inflammation and enable joint healing when they are activated by specific signals. Our findings could aid in devising new therapies for rheumatoid arthritis and many other inflammatory diseases involving fibroblasts.

PI_NAMEs: ZOU, ANGELA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Affect;Apoptotic;Architecture;Arthritis;arthritis therapy;Autoimmune Diseases;Autoimmunity;Automobile Driving;axl receptor tyrosine kinase;Binding;Bioinformatics;Biology;Cell Respiration;Cells;Data;Disease;Disease remission;doctoral student;Exhibits;experience;Faculty;Family;Fibroblasts;Fibrosis;Flare;Fostering;Future;Genes;Genetic Transcription;healing;Homeostasis;Immune response;Immunology;immunoregulation;Immunosuppression;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory marker;joint inflammation;Joints;K/BxN model;Knock-out;Knockout Mice;Knowledge;Leukocytes;Ligands;Mediating;Mentors;MERTK gene;Metabolic;metabolic abnormality assessment;Microscopy;Modeling;mouse model;Mus;Nature;novel;novel therapeutics;Pathologic;Pathway interactions;Patients;Phagocytes;Phosphorylation;Physicians;Play;Population;Principal Investigator;programs;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;Recurrent disease;Regulation;Research Personnel;Residual Neoplasm;Resolution;Rheumatoid Arthritis;Role;Scientist;Serum;Severities;Signal Transduction;single-cell RNA sequencing;skills;success;Synovial Cell;Synovial joint;Synovial Membrane;Synovitis;targeted treatment;Testing;Tissues;TNF gene;transcriptome sequencing;transcriptomic profiling;transcriptomics;TYRO3 gene;uptake;Wild Type Mouse

PROJECT_TITLE: Fibroblast-mediated inflammatory resolution of rheumatoid arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative  Ninety percent of cancer related deaths are due to metastatic dissemination to distal organs, thus it is of great interest to study molecular mechanisms that contribute to metastases. Of interest, mitochondria have emerged as important organelles in tumorigenesis and metastasis. This project seeks to gain a mechanistic understanding of a novel mitochondrial signaling pathway that positively influences tumor cell invasion and metastasis, which would serve as the basis for new therapeutics targeting metastatic disease.

PI_NAMEs: BOULTON, DILLON  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 3-Dimensional;4T1;Ablation;Address;Binding;Binding Proteins;Biological Assay;Breast;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Calcium;Calcium Binding;Cause of Death;Cell Death;cell motility;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Co-Immunoprecipitations;Data;Detection;Development;Disease;Distal;Dominant-Negative Mutation;EF-Hand Domain;Goals;Growth;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;hazard;Immunohistochemistry;Immunoprecipitation;In Vitro;in vitro Assay;in vivo;in vivo imaging system;in vivo Model;Injections;interest;Invaded;knock-down;Knockout Mice;Ligation;live cell imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Matrix Metalloproteinases;MDA MB 231;Measurement;Mediating;Melanoma;Messenger RNA;Mitochondria;Mitochondrial Membrane Protein;Modeling;Molecular;mRNA Expression;Myosin ATPase;Myosin S-2;Neoplasm Metastasis;neoplastic cell;Neuroglia;Neurons;new therapeutic target;Normal tissue morphology;novel;novel therapeutics;Organ;Organelles;Outer Mitochondrial Membrane;Pancreas;pancreatic cancer cells;Patients;pharmacologic;Phenocopy;Phenotype;Primary Neoplasm;Process;Production;Proliferation Marker;Prostate;prostate cancer cell line;protein function;Recombinant Proteins;rho GTP-Binding Proteins;rho GTPase-activating protein;Role;Sampling;Secondary to;Signal Pathway;Signal Transduction;Site;small hairpin RNA;Small Interfering RNA;spheroids;System;targeted treatment;Tertiary Protein Structure;Testing;therapeutic target;Tissues;trafficking;Transfection;tumor;Tumor Cell Invasion;tumor growth;Tumor Promotion;tumorigenesis;tumorigenic;United States;Work

PROJECT_TITLE: The role of MIRO2 in tumor cell invasion and metastasis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Lung;Lung Cancer;Nanotechnology;Radiation Oncology

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The goal of this project is the improvement of cancer therapy by employing nanoparticles as image contrast and radiation therapy amplifying agents. The nanoparticles are visible in magnetic resonance imaging and provide a boost of extra energy to their immediate surroundings during therapeutic irradiation. The preferential killing of cancer cells in the tumor will lead greater tumor shrinkage and longer overall survival relative to radiation treatment alone.

PI_NAMEs: BERBECO, ROSS I. (contact);TILLEMENT, OLIVIER

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: A549;Aorta;Biodistribution;Biological;biomaterial compatibility;Bismuth;Blood Vessels;Brain Neoplasms;cancer cell;Cancer Patient;cancer therapy;Chemistry;Clinic;Clinical;clinical practice;clinical translation;clinically relevant;Collaborations;contrast enhanced;contrast imaging;Contrast Media;Dana-Farber Cancer Institute;Data;Dedications;design;Disease;Dose;Dose Limiting;Drug Kinetics;effective therapy;Environment;Esophagus;Exhibits;Formulation;Gadolinium;Goals;Histopathology;Image;improved;in vivo;industry partner;innovation;irradiation;Lead;Letters;Lung;lung lesion;Lung Neoplasms;Magnetic Resonance Imaging;Malignant neoplasm of lung;Methods;Modeling;nano;nanoparticle;Non-Small-Cell Lung Carcinoma;nonhuman primate;Normal tissue morphology;novel;Operative Surgical Procedures;Organ;Paper;particle;patient population;Patient risk;Patients;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;pre-clinical;Process;Property;prototype;Radiation;Radiation Oncology;Radiation Physics;Radiation therapy;Research Personnel;Rodent;Safety;scale up;Schedule;Solid Neoplasm;Structure;success;Technology;Testing;Therapeutic;Therapy Evaluation;Toxic effect;Translating;translational model;Translations;trend;tumor;tumor growth;Tumor Tissue;uptake;Work

PROJECT_TITLE: Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Approximately two-thirds of patients diagnosed with cancer in the United States will be cured of their disease using a combination of surgery, radiation and chemotherapy, but progress towards enhanced survival in adults with advanced and metastatic disease has been painfully slow, even in the era of targeted therapies, and new, more effective therapies are desperately needed. TYRO3 is a member of the TAM-family of receptor tyrosine kinases that is aberrantly expressed, promotes tumor cell survival and/or proliferation, and has been associated with poor prognosis in numerous human cancers, including melanoma, colorectal carcinomas, and lymphoma. Our preliminary data also suggest that agents targeting TYRO3 may be particularly useful for immuno-oncology applications, therefore, the studies described here aim to develop potent and selective TYRO3 inhibitors suitable for clinical application and as such, may have a direct impact on outcomes and/or quality of life for patients with advanced cancers.

PI_NAMEs: GRAHAM, DOUGLAS K;WANG, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acute leukemia;Adult;Advanced Malignant Neoplasm;Biochemical;Biological Assay;cancer cell;Cancer Model;cancer therapy;cell killing;Cell Line;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellular Assay;Chemotherapy and/or radiation;clinical application;clinical translation;Clinical Trials;Colon Carcinoma;Colorectal Cancer;Cytotoxic Chemotherapy;Data;Development;Diagnosis;Disease;Drug Design;Drug Kinetics;effective therapy;Family;Family member;Hematologic Neoplasms;Human;Immune;Immunocompetent;Immunooncology;in vivo;Induction of Apoptosis;inhibitor;Innate Immune Response;kinase inhibitor;Large Intestine Carcinoma;Lead;Lymphoma;Lymphoma cell;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;member;MERTK gene;Methods;Modeling;Molecular Target;Mus;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Oncogenic;Operative Surgical Procedures;Outcome;Pain;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phosphorylation;Phosphotransferases;Play;pre-clinical;Productivity;Prognosis;Property;Protac;Quality of life;Receptor Protein-Tyrosine Kinases;Research Personnel;Resistance;Role;small molecule;Structure;subcutaneous;targeted agent;targeted treatment;Therapeutic;therapeutic target;Toxic effect;tumor;tumor growth;Tumor Immunity;Tumor Promotion;tumor xenograft;TYRO3 gene;Tyrosine Kinase Inhibitor;Ubiquitination;United States;validation studies;Work;Xenograft Model

PROJECT_TITLE: Novel TYRO3 inhibitors for treatment of cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]