NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Acetaminophen (paracetamol), the most commonly used painkiller, is safe when used within therapeutic doses, but its overdose can lead to liver injury, liver failure, and even death. While pathways that trigger acetaminophen-induced liver injury have been extensively studied, those that lead to disease progression or recovery from acetaminophen toxicity are poorly understood. This project will investigate how liver toxicity is halted and liver repair is controlled endogenously during acetaminophen-induced liver injury. The proposed studies are expected to uncover previously unknown regenerative mechanisms in the liver and suggest new therapeutic approaches against acetaminophen-induced liver disease.

PI_NAMEs: PARK, PYONG WOO  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Accidents;Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;Acetylcysteine;Acute Disease;Acute Liver Failure;Affect;Analgesics;anti-microbial peptide;Antidotes;Binding;Biological;Blood Coagulation Factor;cell motility;Cell Physiology;Cell Proliferation;Cell surface;Cessation of life;Chemotactic Factors;Chronic Disease;Cicatrix;Clinical;combat;Complex;cytokine;Data;Destinations;Disease Progression;Dose;Drops;drug induced liver injury;Endogenous Factors;Etiology;Extracellular Matrix;Generations;Genetic;Goals;Growth Factor;healing;Hemostatic function;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Hepatocyte;Hepatotoxicity;HMGB1 gene;Immobilization;Impairment;in vivo;Inflammation;Inflammatory;injured;Injury;injury and repair;Innate Immune Response;Liver;liver cell proliferation;Liver diseases;Liver Failure;liver injury;liver repair;loss of function;Matrilysin;Mediating;Molecular;Molecular Conformation;Mus;N-acetyl-4-benzoquinoneimine;Necrosis;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Organism;Outcome;Overdose;Pathogenesis;Pathway interactions;Patient Admission;Peptide Hydrolases;Phenotype;Predisposition;prevent;Process;programs;Proliferating;Recovery;regenerative;repaired;Resolution;response;response to injury;Role;Signal Transduction;Structure;Sulfate;syndecan;Testing;Therapeutic;tissue injury;tissue repair;Tissues;Toxic effect;Treatment Efficacy;Western World;Wild Type Mouse

PROJECT_TITLE: HSPG Interactions in Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: The proposed research is relevant to public health because rates of obesity and eating disorders are increasing and there are significant health and financial costs associated with this increase. Understanding the neural mechanisms that underlie feeding, and especially those underlying non-homeostatic feeding, which can drive feeding in the absence of energy deficit, is necessary to identify new targets and approaches to treat obesity and other eating disorders. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental basic science discoveries, using innovative approaches, with the goal of ultimately improving health.

PI_NAMEs: FURMAN, KATHERINE L (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Affect;Amygdaloid structure;Anatomy;Animals;Appetite Regulation;Area;Arousal;Basic Science;Behavior;Behavioral;Behavioral Paradigm;Body Weight;Brain;Cerebral cortex;Complex;Consummatory Behavior;Consumption;craving;Decision Making;diet and exercise;Disease;Dissociation;Eating;Eating Disorders;Equilibrium;experience;experimental study;feeding;Feeding behaviors;Financial cost;Food;food consumption;Food Intake Regulation;Fostering;Future;Goals;grasp;Health;Health Care Costs;Heterogeneity;Human;Hypothalamic structure;improved;Infusion procedures;innovation;Intervention;Lateral;Learning;locus ceruleus structure;Maps;Mediating;melanin-concentrating hormone;Metabolic;Mission;Modernization;Motivation;Mus;neural;neural circuit;neuromechanism;Neurons;new therapeutic target;Nose;Nucleus Accumbens;Nutrient;Nutritional;Obesity;optogenetics;Pattern;peptide hormone;Phenotype;Physiological;Population;Prevalence;Property;Public Health;REM Sleep;Research;Rewards;Role;Self Stimulation;Sleep;sleep behavior;Societies;Structure of nucleus infundibularis hypothalami;System;Therapeutic;United States;United States National Institutes of Health;Work;zona incerta

PROJECT_TITLE: Elucidating MCH neural circuitry underlying consummatory behavior


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Circulating CFH and mtDNA are both associated with severe sepsis in patients. Here, we present a novel link between oxidized CFH, release of mtDNA from the vascular endothelium and increased endothelial permeability.

PI_NAMEs: RIEDMANN, KYLE JOSEPH (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Acute Respiratory Distress Syndrome;Affect;Alveolar;Animals;Antioxidants;Apoptosis;Biogenesis;Biomedical Research;Blood capillaries;Blood Platelets;Blood Vessels;career;Cell Culture System;Cell secretion;Cells;Cessation of life;Circulation;clinically relevant;Coculture Techniques;Critical Illness;Cytolysis;Data;Development;Dextrans;Disease;Disease Progression;DNA;Education;electric impedance;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;experience;extracellular;extracellular vesicles;Foundations;Functional disorder;Genetic;Growth;Hemoglobin;Human;Immunologic Receptors;Inflammatory;inhibitor;Intensive Care Units;interdisciplinary approach;Interferons;Knowledge;Link;Lung;lung microvascular endothelial cells;Mediating;Methemoglobin;Methods;Microvascular Permeability;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;Morphology;mortality;multidisciplinary;Necrosis;neutrophil;novel;novel therapeutics;Organ;Outcome;oxidation;oxidative damage;Pathogenesis;Pathogenicity;Patients;Pattern;Permeability;Physiological;Plasma;Process;Production;Prospective cohort;Reporting;Research;response;Role;Sepsis;septic;septic patients;Septic Shock;Signal Pathway;Signal Transduction;small molecule inhibitor;Superoxides;Technical Expertise;Testing;therapeutically effective;TLR9 gene;translational scientist;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium

PROJECT_TITLE: Cell-Free Hemoglobin Induces Endothelial Mitochondrial Oxidative Damage Causing Extracellular DNA Release


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Natural killer (NK) cells can recognize and kill cancer cells; however, their use in adoptive cancer therapy has been limited by several factors including limited supply of cells and host immune responses that interfere with NK cell survival and targeting of cancer cells. This Program will advance our understanding of basic immunology of human NK cells and develop off-the-shelf NK cell products that can optimally target specific types of cancer.

PI_NAMEs: MILLER, JEFFREY S. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adoptive Cell Transfers;Adoptive Transfer;Adult;Affinity;Allogenic;allotransplant;Antibodies;arm;Autologous;Binding;Biology;Biometry;cancer cell;cancer therapy;cancer type;CD19 gene;CD276 gene;CD8-Positive T-Lymphocytes;Cell Death Induction;Cell Line;Cell Survival;Cell Therapy;Cells;Cellular Metabolic Process;chimeric antigen receptor;chimeric antigen receptor natural killer cells;Clinic;Clinical;clinical efficacy;Clinical Investigator;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost;Cytomegalovirus;Data;Development;Dose;early phase trial;engineered NK cell;Exhibits;experience;Fc Receptor;FCGR3B gene;Funding;Generations;Genes;Goals;Human;Immune;Immune response;Immunogenetics;Immunologic Memory;Immunologic Monitoring;Immunologics;Immunology;improved;improved outcome;in vivo;Individual;induced pluripotent stem cell;Infusion procedures;Institution;Interleukin-15;Interleukin-2;International;intraperitoneal;K-562;Knock-out;leukemia relapse;Link;Maintenance Therapy;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Mediating;medical specialties;Membrane;Methylation;Minnesota;Modeling;Monoclonal Antibodies;Natural Increases;Natural Killer Cell Immunotherapy;Natural Killer Cells;next generation;NK cell therapy;Non-Hodgkin's Lymphoma;novel;overexpression;Oxidative Stress Induction;Patients;Performance;Phase I Clinical Trials;Phase I/II Trial;Population;Positioning Attribute;pre-clinical;Preclinical Testing;Process;Productivity;programs;Property;Proteins;Publishing;receptor;Relapse;Research Support;Resources;response;rituximab;safety testing;Signal Transduction;Solid Neoplasm;Source;Specificity;success;T-Cell Activation;targeted delivery;Testing;Tissues;transgene expression;translational scientist;Transplantation;trispecific killer engager;tumor;Tumor Antigens;Work

PROJECT_TITLE: NK cells, their receptors and cancer therapy


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Proper cell division requires proteins in the kinetochore complex to sense tension exerted on chromosomes to ensure they are segregated correctly. Although harmful genome imbalance known as aneuploidy results when this process goes awry, the regulation and molecular details of this tension-sensing activity remain unknown. In this proposal, we will investigate how cells regulate protein factors to control kinetochore tension-sensing and also how these proteins function to carry out these mechanisms, which will give insight into how aneuploidy arises and how to prevent it.

PI_NAMEs: STEWART, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Adult;Affect;Affinity;Anaphase;Aneuploidy;Binding;Binding Sites;Biochemical;Biological Assay;biophysical analysis;biophysical techniques;Biophysics;cancer type;Cell division;Cell Survival;Cells;Chromosome Segregation;Chromosomes;Complex;Data;daughter cell;Defect;Development;Disease;DNA;Ensure;experience;experimental study;Face;Genetic;genetic information;Genome;Goals;Human;In Vitro;in vivo;insight;intermolecular interaction;Investigation;Kinetochores;Location;Maintenance;Malignant Neoplasms;mechanical force;Microtubules;Mitosis;Mitotic;model organism;Molecular;Molecular Conformation;mutant;Mutate;Mutation;novel;optic trap;optical traps;Phenotype;Phosphorylation;Phosphotransferases;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;protein complex;protein function;Protein Region;Proteins;Publications;Publishing;receptor;Recombinant Proteins;reconstitution;Regulation;Research;response;Saccharomyces cerevisiae;segregation;sensor;Sirolimus;Sister Chromatid;System;Testing;Therapeutic;tool;treatment strategy;Work;Yeasts

PROJECT_TITLE: Investigating the regulation and mechanism of tension-sensors Stu2 & Ndc80c

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: We have discovered a unique population of NK cells that is primed to better attack cancer and can be targeted with immune engagers to enhance the specificity of NK cell-mediated killing. We will test the best way to use this knowledge in first-in-human clinical trials with the goal of making the treatment off-the-shelf for easy and feasible export to the cancer community. Clinical trials and pre-clinical investigation will test research themes that can be applied broadly against all cancer types.

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adoptive Transfer;Allogenic;antibody-dependent cell cytotoxicity;Antigens;base editing;Benchmarking;Blood;cancer therapy;cancer type;Cell Line;Cells;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Communities;Cytomegalovirus;Disease;Dose;Effector Cell;Eligibility Determination;Engineering;exhaustion;FCGR3B gene;first-in-human;Frequencies;Funding;Generations;glycogen synthase kinase 3 beta inhibitor;Goals;Homologous Transplantation;Immune;immune activation;Immune response;Immunologic Monitoring;immunological synapse;improved;In complete remission;in vivo;induced pluripotent stem cell;Inflammatory Response Pathway;Infusion procedures;Ink;Interleukin-15;intraperitoneal;Investigation;K-562;Knowledge;Learning;leukemia;leukemia treatment;Ligands;Link;Malignant Neoplasms;Marrow;Mediating;Metabolic;Methylation;Modeling;Myeloid-derived suppressor cells;Natural Killer Cell toxicity;Natural Killer Cells;neoplasm immunotherapy;NK cell therapy;novel;novel strategies;Pathway interactions;patient derived xenograft model;Patient Monitoring;Patients;phase I trial;pluripotent stem cell differentiation;Population;pre-clinical;preclinical study;Preclinical Testing;Process;programs;Property;receptor;reconstitution;Refractory;Regulatory T-Lymphocyte;Relapse;Remission Induction;Research;research clinical testing;Research Personnel;Resistance;Resolution;Role;Signal Transduction;Solid Neoplasm;Specificity;success;synergism;Systemic Therapy;T-Cell Activation;Technology;Testing;Therapeutic;Translations;trispecific killer engager;TYROBP gene;Universities;Xenograft Model

PROJECT_TITLE: NKG2C+ Adaptive NK Cells For AML


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Rheumatoid Arthritis is an autoimmune disease affecting up to 1% the people in the United States. This proposal aims to better understand how T cells, a type of immune cell involved in RA, migrate toward the inflamed joint and if certain T cell populations are responsible for pathology. Better understanding of these cell populations could lead to better therapeutics for RA.

PI_NAMEs: BRACERO, SABRINA ESMERALDA (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Affect;Area;ATAC-seq;Autoimmune Diseases;Automobile Driving;Bioinformatics;Biometry;Blood;bone;Bone Marrow;candidate identification;Cartilage;CCL2 gene;CD4 Positive T Lymphocytes;cell motility;Cells;chemokine;chemokine receptor;Chimera organism;Chronic;Collagen Arthritis;CRISPR screen;cytokine;Data;Dedications;Development;Disease;Environment;Enzyme-Linked Immunosorbent Assay;experience;Flow Cytometry;Genes;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;Human;Immune;Immunohistochemistry;Immunology;Infiltration;Inflammatory;Inflammatory Arthritis;Integral Membrane Protein;Investigation;joint inflammation;Joints;Knock-out;Laboratory Finding;Lymphocyte Biology;Macrophage;Memory;Mentors;migration;Modeling;monocyte chemoattractant protein 1 receptor;Mononuclear;mouse model;multiplex assay;Mus;Myeloid Cells;Pathogenesis;Pathology;Patients;Peripheral Blood Mononuclear Cell;Persons;Population;Positioning Attribute;Production;programs;promoter;receptor;recruit;Regulation;Research;Research Personnel;Rheumatoid Arthritis;Role;skills;Synovial Fluid;Synovitis;System;systemic autoimmune disease;T cell infiltration;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;United States;Work

PROJECT_TITLE: Regulation and function of CCR2 on T cells in Rheumatoid Arthritis


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE: OVERALL To respond adaptively to the environment, the brain must process information to develop accurate and stable representations of the current state of the environment (termed “state representation” in computational neuroscience). Our Center focuses on the unifying hypothesis that neural processes underlying state representation dysfunction are relevant to psychosis, providing a window into pathophysiologic heterogeneity and precision treatment.

PI_NAMEs: REDISH, A DAVID;VINOGRADOV, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: ZALCMAN, STEVEN J

PROJECT_TERMS: Ablation;Affect;animal data;Behavior;behavior measurement;Behavioral;Brain;cell type;Characteristics;Clinical;cognitive training;computational neuroscience;Computer Models;Data;data acquisition;Data Analyses;data modeling;early psychosis;Electroencephalography;Environment;Equilibrium;Expectancy;experimental study;Failure;Feedback;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Generations;genetic manipulation;genetic variant;Heterogeneity;Human;improved;Leadership;Learning;lens;Mediating;Mental disorders;Methodology;Modeling;Modification;Mus;N-Methylaspartate;network models;neural;neural information processing;Neuronal Plasticity;neurophysiology;Noise;nonhuman primate;novel;Outcome;Parameter Estimation;Participant;Patient Recruitments;Patients;Pattern;Performance;Persons;Physiology;Precision therapeutics;Process;Psychopathology;Psychoses;Randomized;Regimen;Reversal Learning;Role;sensory system;Signal Transduction;Slice;Structure;Subgroup;Synapses;System;Testing;Training;Translating;treatment as usual;Variant

PROJECT_TITLE: Dysfunctional State Representations in Psychosis: From Neurophysiology to Neuroplasticity-based Treatment


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Contraception/Reproduction;Estrogen;Genetics;Infertility;Uterine Cancer;Women's Health Research

ORG_CITY: LARAMIE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative Tissues of the female reproductive tract, and the endometrium in particular, undergo cycles of proliferation and differentiation that are coordinated by the female sex hormones estradiol and progesterone, respectively. We recently established that members of the progesterone receptor membrane component (PGRMC) family are essential for estradiol-induced proliferation of epithelial tissue within the endometrium. In this application, we seek to establish the mechanism(s) by which these proteins function to ensure that estradiol-induced proliferation is allowed to normally occur.

PI_NAMEs: PRU, JAMES K (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Ablation;Adenomyosis;Aerobic;aerobic glycolysis;Anabolism;Appearance;building materials;Carbon;Cell Proliferation;Cells;chemotherapy;crosslinking and immunoprecipitation sequencing;Development;Disease;early pregnancy;Endometrial;Endometrial Carcinoma;Endometrial Hyperplasia;endometriosis;Endometrium;Enzymes;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Estradiol;estrogenic;Estrogens;Estrous Cycle;Evaluation;Event;experimental study;Failure;Family;Family member;Female;female fertility;female reproductive tract;female sex hormone;Gene Expression;gene function;Genes;Glucose;Glycolysis;Gonadal Steroid Hormones;Human;implantation;In Vitro;in vivo;Infertility;Leiomyoma;Link;LoxP-flanked allele;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Measures;Mediating;member;Membrane;Menorrhagia;Menstrual cycle;Messenger RNA;Metabolic;Metabolism;model design;Molecular;mouse model;mRNA Expression;Mus;Mutagenesis;novel;Outcome;Output;overexpression;Oxidative Stress;Oxygen;Phase;Physiological;Polyribosomes;posttranscriptional;premature;Prevalence;Primary Cell Cultures;Primates;Progesterone;Progesterone Receptors;Proliferating;proliferative phase Menstrual cycle;protein function;Proteins;Proteomics;receptor;Regulation;Reproductive Process;reproductive senescence;Resistance;response;RNA Splicing;RNA-Binding Proteins;Severities;Signal Transduction;Signaling Molecule;stem;Sterols;subfertility;Testing;Tissue Expansion;Tissues;Transcription Process;transcriptome sequencing;Transgenic Mice;Translation Initiation;tumor xenograft;Tumor-Derived;uterine receptivity;Uterus

PROJECT_TITLE: Regulation of endometrial proliferation by the PGRMC family

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

PI_NAMEs: VINOGRADOV, SOPHIA  (contact)

PROJECT_TERMS: Accountability;Address;Advocacy;Behavioral;career development;Centers of Research Excellence;Climate;Communication;Communities;Community Health Education;Community Outreach;community partners;Computer Models;conflict resolution;Data;data integrity;data management;data quality;data sharing;development policy;diversity and inclusion;Education;Educational Activities;Educational workshop;Ensure;equipment acquisition;Equipment and Supplies;Expenditure;Fostering;Goals;graduate student;Grant;Institution;interdisciplinary collaboration;Knowledge;Leadership;Medical Students;member;Mission;Modeling;Neuronal Plasticity;neurophysiology;next generation;novel;outreach;outreach program;Policies;Postdoctoral Fellow;Preparation;Procedures;Program Development;programs;Psychiatry;Psychoses;quality assurance;Quality Control;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Science;Structure;symposium;Technology;timeline;Training;Training and Education;Training Programs;Translating;undergraduate student;Vision;webinar;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Epidemiology and population genetics suggest that non-familial forms of PD (90% of PD cases) result from a complex interaction between age, genetic, and environmental risk factors. Elucidating how non-coding risk variants and their target genes, specifically glycoprotein nonmetastatic melanoma protein B (GPNMB), functionally contribute to disease pathogenesis will facilitate identification of new therapeutic targets for etiological treatment of PD.

PI_NAMEs: LO BU, RIANA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Age;Aging;Autophagocytosis;Autophagosome;Binding;Brain;brain tissue;Chromatin Structure;Chronic;Complex;CRISPR/Cas technology;cytokine;Data;Data Set;Development;Disease;Disease susceptibility;disorder risk;Distal;DNA;Electrophoretic Mobility Shift Assay;Elements;Enhancers;Environmental Risk Factor;Epidemiology;epigenomics;Etiology;Functional disorder;gain of function;Gene Deletion;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Enhancer Element;Genetic Risk;genetic risk factor;Genetic Transcription;genome editing;genome wide association study;genomic locus;Genomic Segment;glial activation;Glycoproteins;human pluripotent stem cell;Impairment;Individual;Inflammasome;Inflammation;Inflammatory;inhibitor;insight;Integral Membrane Protein;Link;Literature;loss of function;lysosome membrane;Macrophage;Mediating;Melanoma;Membrane;Microglia;migration;Molecular;Molecular Chaperones;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;new therapeutic target;Nonmetastatic;novel;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Phagocytes;Phagocytosis;Play;Population Genetics;Probability;protein B;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Regulatory Element;Reverse Transcriptase Polymerase Chain Reaction;Risk;risk variant;Role;Single Nucleotide Polymorphism;sporadic Parkinson's Disease;Stress;Substantia nigra structure;System;Testing;theories;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Untranslated RNA;Up-Regulation;Upstream Enhancer;Variant;Work;zinc finger nuclease

PROJECT_TITLE: Dissecting GWAS Identified Risk Variants in Parkinson's Disease – Functional Role of GPNMB in the Pathogenesis of PD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: CHAFEE, MATTHEW V (contact)

PROJECT_TERMS: Action Potentials;Anatomy;Area;Back;Behavior Control;Behavioral;behavioral response;Belief;Biology;Brain;Cells;Clinical;Cognition;Cognitive deficits;cognitive training;Corpus striatum structure;Data;Decision Making;Defect;DNA Sequence Alteration;Dorsal;early psychosis;Electrodes;Electroencephalography;Equilibrium;Exhibits;Failure;Functional disorder;Genetic;Human;Impaired cognition;Impairment;improved;indexing;Individual;Learning;Link;Measures;Mediating;Monkeys;N-Methyl-D-Aspartate Receptors;neural;Neural Network Simulation;Neuronal Plasticity;Neurons;neurophysiology;neurotransmission;Noise;nonhuman primate;Parietal;Parietal Lobe;Patients;Pattern;Perception;Perceptual Disorders;Persons;pharmacologic;Play;Prefrontal Cortex;Process;Production;Psychoses;psychosis risk;Regimen;response;Role;Schizophrenia;Series;Signal Transduction;Silicones;Structure;Symptoms;Synapses;Synaptic Receptors;Synaptic Transmission;Techniques;Testing;Thinking;Time;Training;Translating

PROJECT_TITLE: Spike Timing Defects and State Representation Impairments in Nonhuman Primates


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Non-small cell lung cancer (NSCLC) is the leading cause of cancer related deaths worldwide with frequent recurrence and limited treatment options. Despite advances in immune checkpoint therapies, a disconnect remains in patient expression and treatment response, highlighting the need to determine the mechanisms that facilitate therapeutic resistance. Our proposed studies will uncover mechanisms of immune checkpoint expression and define a new targeted treatment for lung cancer.

PI_NAMEs: THOMAS-JARDIN, SHAYNA  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: 5' Untranslated Regions;Amino Acids;arm;biological adaptation to stress;Biological Assay;cancer cell;Cancer Etiology;Cancer Patient;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;checkpoint therapy;Clinical;Coculture Techniques;Data;Dendritic Cells;deprivation;Development;endoplasmic reticulum stress;Environment;Eukaryotic Initiation Factors;experience;fitness;Heme;heme biosynthesis;humanized mouse;Hypoxia;Immune;Immune Cell Suppression;immune checkpoint;immune checkpoint blockade;Immune response;Immunocompetent;In Vitro;in vivo;inhibitor;ITIM;Ligands;Luciferases;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;Membrane Glycoproteins;Messenger RNA;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural Killer Cells;Nature;neoplastic cell;new combination therapies;Non-Small-Cell Lung Carcinoma;Oncogenic;Open Reading Frames;Osmosis;Outcome;Pathway interactions;Patients;PD-1 blockade;Phosphorylation;Phosphotransferases;polysome profiling;Population;programmed cell death ligand 1;programmed cell death protein 1;Prokaryotic Initiation Factor-2;Protein Biosynthesis;protein expression;Proteins;receptor;Receptor Cell;Recurrence;Regulation;Reporter;Research;resistance mechanism;response;ribosome profiling;Role;Solid Neoplasm;Starvation;Stimulus;Stress;synergism;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;translational study;Translations;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Immune Checkpoint Regulation by the Integrated Stress Response Pathway in Lung Ca


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Evaluating the Influence of Culture and Risk Perception on HPV Vaccination Intention among Haitian Immigrant Women Living with HIV Project Narrative Affective dimensions of risk perception and cultural worldviews may have a significant role in Haitian immigrant women’s intention of undergoing HPV vaccination. When there is no prior experience of a disease, and minimal knowledge is available, emotions along with cultural influences can shape an individual’s appraisal of their disease risk and guide their behavior decisions. This proposed study aims to understand how affective dimensions of risk perception, which are shaped by cultural worldviews, influence the HPV vaccination intention among Haitian immigrant women with and without HIV.

PI_NAMEs: GUILLAUME, DOMINIQUE GISELE (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acculturation;Address;Affect;Affective;Behavior;Behavior Therapy;black women;burden of illness;Cancer Etiology;cancer prevention;cancer risk;cervical cancer prevention;Cognitive;cognitive process;Communication Programs;Communities;Community Health;Data;Decision Making;Development;Dimensions;Disease;disorder risk;Disparity;Emotional;Emotions;ethnic minority;Ethnic Population;Evaluation;experience;Feeling;Female;Florida;Formulation;Geographic Locations;Haitian;Health;Health behavior;health communication;health disparity;Health Promotion;Health Status;high risk;HIV;HIV Infections;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immigrant;Immunization;Incidence;Individual;Intention;Intervention;Intuition;Knowledge;Link;Literature;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mentors;Methods;Minority Status;Modeling;Perception;Planning Theory;Population;population health;Population Heterogeneity;Prevalence;prevent;Prevention Measures;Preventive;Procedures;Process;psychosocial;Race;racial disparity;racial minority;racial population;racism;Reporting;Research;Risk;risk perception;Role;Sampling;Sexism;Sexual Transmission;Shapes;Shoulder;Social Environment;social stigma;Societies;socioeconomics;Strategic Planning;Thinking;Treatment Cost;Uncertainty;United States;uptake;Variant;Woman;Women's mortality

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Given the foundational importance of early brain development for subsequent psychopathology, it is imperative to capture children’s everyday experiences with their caregivers in relation to changes in infant brain development. Addressing the need for more ecologically-valid approaches to our understanding of children’s early experiences, this study uses a newly developed wearable device that can dynamically, unobtrusively, and continuously measure patterns of physical proximity between children and caregivers, regardless of location. The proposed project will yield extraordinary insight into the early environment from a child-centered perspective during the first 18 months of life, with relevance to NIMH’s mission to determine the biological and psychological mechanisms by which the environments affect neural and behavioral development.

PI_NAMEs: HUMPHREYS, KATHRYN LEIGH (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Achievement;Address;Adult;Affect;Age;Amygdaloid structure;Award;Behavior;Behavior assessment;Behavioral;Biological;Birth;Brain;brain circuitry;brain shape;brain volume;Caregivers;caregiving;Caring;Characteristics;Child;Child Abuse and Neglect;Coupled;design;Development;direct application;early childhood;early experience;Early Intervention;emotion regulation;Emotional;Emotions;Environment;environmental enrichment for laboratory animals;experience;Exposure to;Family;Human;improved;infancy;Infant;Infant Behavior;innovation;insight;Institutionalized Child;Insula of Reil;Intervention;Knowledge;Laboratories;Language;Learning;Life;Life Experience;Link;Location;Maps;Measurement;Measures;Medial;Mediation;Mental disorders;Mental Health;Methods;Mission;Modeling;Monitor;Moods;MRI Scans;multimodal neuroimaging;National Institute of Mental Health;Nature;neglect;neural;Neurocognitive;neurodevelopment;neuroimaging;Neurosciences;Outcome;Parents;Pattern;Prefrontal Cortex;Pregnancy;Pregnant Women;preventive intervention;primary caregiver;psychologic;Psychopathology;psychosocial;Recording of previous events;recruit;Research;Risk;Risk Reduction;Scanning;Sensory;Severities;Shapes;Source;Speech;Symptoms;Technology;Testing;Theoretical model;theories;Time;tool;Variant;wearable device;Woman

PROJECT_TITLE: Parent-child proximity and emerging psychopathology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Suicide is the second-leading cause of death among adolescents ages 10-14, making identification of risk factors for self-injurious thoughts and behaviors (SITBs) in early adolescence a research priority. Weight discrimination, among the most common types of discrimination reported by adolescents, might be one such risk factor and may disproportionately impact sexual and gender minority (SGM) adolescents who are at particularly high risk of SITBs. The proposed study will analyze associations between weight discrimination and SITBs and whether they differ for SGM adolescents in a large national sample of early adolescents, informing future interventions to promote mental health, prevent suicide, and reduce disparities in this population by addressing social determinants of health.

PI_NAMEs: LEONARD, SARAH IRENE (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: 12 year old;Address;Adolescence;Adolescent;adolescent mental health;Adult;Age;Behavior;Birth;Body Weight;Brain;Cause of Death;Characteristics;cisgender;cognitive development;completed suicide;critical period;Data Analyses;Data Science;Dedications;Development;Discrimination;Disparity;disparity reduction;early adolescence;Early Intervention;Environment;ethnic discrimination;Ethnic Origin;experience;Feeling suicidal;Foundations;Funding;Future;gender minority;gender minority group;gender minority health;gender minority health disparity;gender minority youth;Goals;health disparity;health disparity populations;health equity;Health Promotion;Heterosexuals;high risk;insight;Intervention;Knowledge;lens;Lesbian Gay Bisexual Transgender;Linear Models;Literature;marginalization;Measures;Mental Health;Mental health promotion;Mentorship;minority stress;minority stressor;Modeling;multilevel analysis;non-suicidal self injury;Nurses;peer;perceived discrimination;Persons;Population;Prevention;preventive intervention;programs;Race;racial discrimination;Recording of previous events;Reporting;Research;Research Priority;Resources;Risk Factors;Risk Reduction;Sampling;Scientist;secondary analysis;sex assigned;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority youth;skills;social health determinants;Stress;suicidal adolescent;suicidal behavior;Suicide;Suicide attempt;Suicide prevention;suicide rate;Thinking;Training;United States National Institutes of Health;Universities;Violence;Weight;Weights and Measures;Youth

PROJECT_TITLE: Weight Discrimination and Self-Injurious Thoughts and Behaviors Among Sexual and Gender Minority Adolescents and their Peers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Psychosis

PI_NAMEs: ROTHWELL, PATRICK  (contact)

PROJECT_TERMS: 16p11.2;22q11.2;Ablation;Algorithms;Automobile Driving;Behavior;behavior measurement;Behavior monitoring;Behavioral;behavioral impairment;behavioral phenotyping;Biological;Brain;Cells;Characteristics;Chronic;cognitive testing;Compensation;Complex;Computer Analysis;Computer Models;conditional knockout;Copy Number Polymorphism;Coupled;Data;design;Disease;disease phenotype;Enterobacteria phage P1 Cre recombinase;Equilibrium;excitatory neuron;Exhibits;Expectancy;experience;experimental study;Failure;Functional disorder;Genes;Genetic;genetic manipulation;Genetic Models;genetic variant;Genetic Variation;genome-wide;Genotype;Heterogeneity;Heterozygote;Human;Impairment;Implanted Electrodes;in vivo;Individual;information processing;inhibitory neuron;Interneurons;Knockout Mice;Link;Measurement;Measures;Medial;Methods;Modeling;Mus;Mutant Strains Mice;Mutation;N-Methyl-D-Aspartate Receptors;network models;neural;neural circuit;Neuronal Plasticity;Neurons;neurophysiology;NMDA receptor A1;nonhuman primate;optogenetics;patch clamp;patient population;Patients;Pattern;pharmacologic;Phenotype;Physiology;Prefrontal Cortex;Process;promoter;Psychoses;Publishing;Pyramidal Cells;Receptor Signaling;Reversal Learning;Rodent;Slice;Synapses;synaptic function;Synaptic Transmission;Syndrome;System;Testing;Translating;Variant;Virus;Weight

PROJECT_TITLE: Genetic and Synaptic Mechanisms of State Representation Impairments in Mice


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Current approaches for the diagnosis of early breast cancer (i.e. mammograms) in particular in women with dense breast tissue have major limitations leading to delayed or missed diagnoses as well as false positive results. This research will develop a new ultrasound imaging platform that allows diagnosing breast cancer with high sensitivity and specificity to enable rapid and effective detection of breast cancer at an early, still curable stage. The widespread and easy availability of ultrasound system in the clinics further improve the applicability this technique and save the lives of many patients through early diagnosis.

PI_NAMEs: DAHL, JEREMY  (contact);PAULMURUGAN, RAMASAMY

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 4T1;Adopted;Adoption;Affinity;aggressive breast cancer;Animal Model;Anxiety;Benign;Binding;Biological Markers;biomarker identification;Biopsy;Blood Vessels;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;Breast Cancer Model;Breast Cancer Patient;breast imaging;breast lesion;breast scan;Cancer Etiology;CD276 gene;Chemistry;Clinic;Clinical;clinical translation;clinically relevant;Computer software;computing resources;contrast enhanced;contrast imaging;cost;design;design and construction;Detection;detection method;Development;Diagnosis;diagnostic accuracy;Disease;Early Diagnosis;Engineering;experimental study;Frequencies;Future;Goals;high risk;Human;human imaging;Image;imaging modality;imaging platform;imaging system;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;Incidence;Lesion;Ligands;Liver;lymph nodes;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Mammography;Metastatic breast cancer;Microbubbles;Modality;molecular imaging;Molecular Target;Monitor;Mouse Mammary Tumor Virus;mouse model;Neoplasm Metastasis;neovasculature;Network-based;neural network;Noise;Normal tissue morphology;novel;Outcomes Research;Patient imaging;patient screening;Patients;performance tests;polyoma middle tumor antigen;pre-clinical;Process;Proteins;radiological imaging;real-time images;Research;Sensitivity and Specificity;Signal Transduction;Source;Specificity;System;targeted imaging;Techniques;Testing;Time;Tissue imaging;Tissues;Transgenic Organisms;Translations;tumor;Ultrasonography;ultrasound;United States;Visualization;Woman;Women's mortality

PROJECT_TITLE: B7-H3 Targeted Ultrasound Molecular Imaging System for Early Breast Cancer and Metastatic Detection

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: MACDONALD, ANGUS W (contact)

PROJECT_TERMS: Adolescent and Young Adult;aged;Algorithms;Behavior;Behavioral;Brain;Clinical;clinical heterogeneity;Data;Data Collection;Data Set;density;early psychosis;Electroencephalography;Equilibrium;experimental study;Failure;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;guided inquiry;Heterogeneity;Human;Impairment;indexing;information processing;Intervention;Link;Maps;Measures;Modeling;Monkeys;Mus;network models;neural;neural circuit;Neuroanatomy;Neuronal Plasticity;neurophysiology;Noise;nonhuman primate;novel;Parietal;Participant;Patients;Pattern;Performance;Persons;Phase;Process;Psychophysiology;Psychoses;Quality of life;recruit;research clinical testing;Scanning;Short-Term Memory;Symptoms;Testing;Time;treatment as usual;Validation;Visit

PROJECT_TITLE: Characterizing State Representation Impairments in People with Early Psychosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Malignant relapse is the biggest reason for failure in treatment of lymphoma. Natural killer (NK) cells can target lymphoma, and we will study genetically engineered, off-the-shelf NK cells directed to multiple targets on lymphoma as new “smart bomb” cellular treatments to limit relapse. Future improvements to enhance NK cell persistence and potency may make this therapy safer, cheaper, and even more effective.

PI_NAMEs: WEISDORF, DANIEL J (contact)

PROJECT_TERMS: Adoptive Transfer;Affinity;Allogenic;antibody-dependent cell cytotoxicity;Antigen Targeting;Antigens;ATAC-seq;Autologous;Autologous Transplantation;B-Cell Lymphomas;Binding;cancer therapy;CD19 gene;CD34 gene;Cell Death Induction;Cell Line;Cell Physiology;Cell surface;Cells;Cellular Metabolic Process;cellular transduction;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;ChIP-seq;Clinical;Clinical Trials;Clip;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cytokine;cytokine release syndrome;Data;Development;disorder risk;Dose;Dose Limiting;engineered NK cell;Engineering;Engraftment;Enzymes;Exhibits;experience;Failure;FCGR3B gene;FDA approved;Funding;Future;gastrointestinal;Gene Deletion;Gene Modified;Genes;Genetic Engineering;Goals;Half-Life;Heterogeneity;high risk;Immune;improved;In complete remission;in vivo;Individual;induced pluripotent stem cell;Infusion procedures;inhibitor;Ink;Interleukin-15;Investigation;Knock-out;Lymphoma;Maintenance Therapy;Malignant - descriptor;manufacturing process;manufacturing run;Mediating;Membrane;Metabolic;metabolic abnormality assessment;metabolic fitness;metabolic profile;Metabolism;Minnesota;Modification;MS4A1 gene;Natural Increases;Natural Killer Cells;NK cell therapy;Non-Hodgkin's Lymphoma;Oral;overexpression;Oxidative Stress Induction;patient derived xenograft model;Patients;phase 1 study;Phenotype;pluripotent stem cell differentiation;post-transplant;pre-clinical;preclinical trial;prevent;Prevention strategy;Process;Production;progenitor;programs;receptor;Relapse;relapse prevention;Reporting;Resistance;response;rituximab;Role;safety study;scale up;Site;small molecule;Specificity;synergism;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Toxic effect;transcriptome sequencing;transgene expression;Translations;Transplantation;Universities;Variant;Work

PROJECT_TITLE: Off-The-Shelf Dual Targeted NK Cells For NHL


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Address;Affect;Auditory;auditory discrimination;Auditory system;Behavioral;Characteristics;Clinical;Cognition;cognitive performance;cognitive training;computational neuroscience;Data;design;disability;early psychosis;efficacy study;Electroencephalography;Equilibrium;Failure;Functional disorder;functional magnetic resonance imaging/electroencephalography;Goals;Hour;Impairment;improved;indexing;Individual;information processing;Intervention;Investigation;Maintenance;Measures;Modification;network models;neural;Neuronal Plasticity;neurophysiology;Noise;Output;Parameter Estimation;Participant;Pathology;Patients;Persons;Precision therapeutics;Process;Psychoses;Randomized;recruit;response;Short-Term Memory;System;Testing;Training;treatment as usual;Treatment Efficacy

PROJECT_TITLE: Neuroplasticity-Based Treatment to Address State Representation Failures in People with Early Psychosis


ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Microglia, which comprise nearly 10-15% of total cells within the mammalian brain, have been linked to neurodegeneration. To understand the mechanisms of microglia-driven neurodegeneration we propose to identify genes that drive microglia-mediated neuronal damage. The identification of genes that govern microglial inflammatory and neurotoxic activation are important for the development of novel therapeutic approaches against neurodegeneration.

PI_NAMEs: SCHAEFER, ANNE  (contact);TARAKHOVSKY, ALEXANDER

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Address;Affect;Animal Model;Area;attenuation;Automobile Driving;Behavior;Binding;BRAF gene;Brain;Brain region;BRD2 gene;Bromodomain;Cells;Cognition;Complex;constitutive expression;Data;Development;Disease associated microglia;DNA Polymerase II;Epigenetic Process;Family;Family member;Foundations;Gene Expression;Gene Expression Profile;gene function;Gene Silencing;Gene Targeting;Genes;Genetic Transcription;genomic locus;Histone Acetylation;Homeostasis;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Link;Macrophage;Mediating;Mediator;Microglia;Modeling;Mus;Myeloid Cells;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Phagocytosis;pharmacologic;Phenotype;Play;Polycomb;Prevention approach;Production;Proliferating;Protein Family;Protein Inhibition;Proteins;Regulation;Relaxation;Research;response;RNA;Role;Signal Induction;Signal Pathway;Signal Transduction;Specific qualifier value;synaptic function;Testing;Tissues;Toxic effect;Transcriptional Regulation

PROJECT_TITLE: Transcriptional Control of Microglia Diversification and Inflammation

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: SPONHEIM, SCOTT R (contact)

PROJECT_TERMS: Address;Animals;Behavioral;Behavioral Paradigm;behavioral phenotyping;Biological Testing;Brain;Clinical;Collection;Computer Models;Data;data acquisition;Data Analyses;Data Collection;data modalities;design;Diffusion Magnetic Resonance Imaging;digital;early psychosis;Ensure;Equilibrium;Functional disorder;functional magnetic resonance imaging/electroencephalography;Goals;Homologous Gene;Human;human data;Impairment;indexing;Individual;Intervention;Knowledge;Link;Maps;Measures;Methods;Modality;model development;Mus;neural;neural circuit;Neuroanatomy;Neuronal Plasticity;neurophysiology;Noise;nonhuman primate;Participant;Performance;phenotypic data;portability;Process;Psychoses;Research;response;Role;Sampling;Secure;Services;Standardization;Structure;System;Translations;Variant;Visualization;Work

PROJECT_TITLE: Translational Neurophysiology Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

PI_NAMEs: REDISH, A DAVID (contact)

PROJECT_TERMS: Adaptive Behaviors;Address;Algorithms;Animals;Behavior;Behavioral;behavioral outcome;Behavioral trial;Cells;Clinical;Clinical Data;Computer Models;Data;data acquisition;Data Analyses;data management;data modeling;Data Set;Ensure;Equilibrium;experimental study;Family;Functional disorder;Generations;Goals;Human;Infrastructure;Ion Channel;Learning;mathematical algorithm;Measures;Membrane;Methodology;Minnesota;Modeling;Monkeys;Neuronal Dysfunction;Neuronal Plasticity;Neurons;neurophysiology;Noise;Pharmaceutical Preparations;Population;Process;Property;Psychoses;Psychotic Disorders;Services;Statistical Data Interpretation;Synapses;System;Techniques;theories;Translating;Universities;voltage;Work

PROJECT_TITLE: Computational Core


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

PHR: Chronic non-alcoholic steatohepatitis (NASH) of the liver is a public health priority because it leads to scarring, or fibrosis, and is the fastest rising cause of primary liver cancer development, affecting millions of individuals worldwide. We propose to clarify the behavior of fibrogenic cells known as hepatic stellate cells that generate scar in this disease, and characterize how they contribute to primary liver cancer. New insights expected to emerge from these studies could significantly advance our understanding of how to prevent and treat liver fibrosis and cancer in patients with NASH, thereby improving the lives of patients with liver disease, which is highly relevant to the NIDDK mission, throughout the developed and developing world.

PI_NAMEs: FRIEDMAN, SCOTT L. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;Affect;American;Animal Model;Animals;Behavior;bile duct;carcinogenicity;CD8-Positive T-Lymphocytes;cell killing;Cells;Cellular biology;Cessation of life;chimeric antigen receptor T cells;Chronic;Cicatrix;Cirrhosis;Clinical;clinically relevant;Coupled;cytokine;Data;defined contribution;Development;Diagnosis;Disease;engineered T cells;Extracellular Matrix;Fibroblasts;Fibrosis;gene regulatory network;Goals;Green Fluorescent Proteins;Growth Factor;Health;Hepatic Stellate Cell;hepatocyte injury;Histologic;Histology;Homeostasis;Human;Hyperlipidemia;Hypertension;improved;Individual;Inflammation;innovation;insight;Knowledge;Ligation;Link;Liver;Liver diseases;Liver Fibrosis;liver injury;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic syndrome;Metagenomics;Methods;Mission;Modeling;morphometry;mouse model;Mus;Myofibroblast;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Obesity;Pathogenesis;Pathogenicity;Patients;permissiveness;Plasminogen;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;Population;Positioning Attribute;Prevalence;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;promoter;Public Health;public health priorities;receptor;Reproducibility;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;single-cell RNA sequencing;Source;Stromal Change;System;T-Cell Depletion;T-Lymphocyte;Testing;therapeutic target;Tissues;tool;transcriptome;transcriptomics;transdifferentiation;Transgenic Mice;tumor;Urokinase;Viral hepatitis;Vitamin A

PROJECT_TITLE: Hepatic stellate cells in NASH fibrosis and HCC


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Alcohol use disorder and other addictions have their origins in early development; consequently, the next generation of addiction researchers should be trained to conduct rigorous work that uses developmental approaches to characterize antecedents leading to these conditions and strategies to mitigate these outcomes. The T32 training program in Development and Neuroadaptations in Alcohol and Addictions (DNA2) at Binghamton University addresses this critical gap by providing highly qualified pre- and post-doctoral trainees with an interdisciplinary training program that focuses on research into developmental influences on drug and alcohol use and use disorder from a translational perspective.

PI_NAMEs: JENTSCH, J. DAVID  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: NEW HAVEN

ORG_NAME: OUI THERAPEUTICS, INC

ORG_STATE: CT

PHR: PROJECTIVE NARRATIVE Suicide is the second leading cause of death among youth in the US; however, effective suicide prevention programs are often difficult to disseminate because their implementation is labor intensive. In response to this gap, Oui Therapeutics seeks to determine the efficacy of Aviva-Y: a mobile technology tool designed to help youth reduce their risk of suicide.

PI_NAMEs: FEUERSTEIN, SETH ;SIMON, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Acute;adolescent suicide;aged;animation;Appointment;Behavior;Behavioral;Caring;Cause of Death;chatbot;Clinical;Cognition;Cognitive;Cognitive Therapy;Companions;Complement;cost;Day Care;design;Development;digital;digital treatment;Educational process of instructing;effective therapy;efficacy evaluation;efficacy trial;emotion regulation;experience;Feedback;Feeling suicidal;Future;Gender;Goals;High School Student;Hospitals;Human body;improved;Incidence;Inpatients;interest;Interruption;Intervention;Learning;Measures;Mediation;Mental Depression;Methods;mobile application;mobile computing;Narration;open label;Outcome;Outpatients;Parents;Participant;Patients;Persons;Phase;phase 1 study;prevent;Prevention program;primary endpoint;programs;psychoeducation;Randomized, Controlled Trials;Recording of previous events;recruit;reducing suicide;relapse prevention;response;secondary endpoint;Self-Injurious Behavior;Shapes;skills;Small Business Technology Transfer Research;suicidal;suicidal adolescent;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Survival Analysis;System;Therapeutic;Thinking;Time;tool;treatment as usual;usability;Youth

PROJECT_TITLE: An Efficacy Trial of Mobile Technology for Reducing and Preventing Adolescent Suicide


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative:  Polycomb Repressive Complex 2 (PRC2) is a key epigenetic regulator of cell identity maintenance; dysregulation of PRC2 function is linked to human cancers and developmental disorders. PRC2 is recruited to CpG island chromatin to mediate trimethylation of histone H3 lysine 27 (H3K27me3), hallmark for gene silencing. The overall goal of the proposed research is to reveal the structural basis of catalysis and chromatin targeting of PRC2 and to connect the structural mechanisms to PRC2 function in cells.

PI_NAMEs: LIU, XIN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Award;Binding;Biochemical;Biological Process;BRCA1 gene;Catalysis;Catalytic Domain;Cell Differentiation process;Cell division;Cell Physiology;Cell Proliferation;cell type;Cells;Chromatin;Clinical;Complex;CpG Islands;Dedications;Development;developmental disease;Disease;DNA Damage;DNA Methylation;epigenetic memory;Epigenetic Process;EZH2 gene;Gene Expression Regulation;Gene Silencing;Genome;Genomic Imprinting;Goals;Histone H3;histone methylation;Human;imprint;Link;Lysine;Maintenance;Malignant Neoplasms;Mediating;Methylation;Molecular;Molecular Analysis;molecular assembly/self assembly;Mutation;paralogous gene;Polycomb;reconstitution;recruit;repaired;Research;response;Role;Signal Pathway;Signal Transduction;stem cell differentiation;Stem cell pluripotency;Structure;X Inactivation

PROJECT_TITLE: Molecular Basis of Gene Regulation by Polycomb Repressive Complex 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunotherapy;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PHR: Survival has been shown to correlate with intraperitoneal NK cells numbers in women with ovarian cancer. We propose to test local delivery of an off-the-shelf NK cell product directly into the peritoneal cavity of women with ovarian cancer, an environment that may evade immune attack. Pre-clinical research proposed in this project will test if we can further manipulate NK cells to enhance specificity and clinical efficacy in ovarian cancer, which will be translatable to other cancers.

PI_NAMEs: GELLER, MELISSA ANN (contact)

PROJECT_TERMS: Affinity;Allogenic;Antibodies;antibody-dependent cell cytotoxicity;Antigens;antitumor effect;Ascites;Binding;Blood;Blood Component Removal;cancer cell;Cancer Patient;cancer stem cell;cancer therapy;CD276 gene;CD32 Antigens;CD34 gene;Cell Count;Cell Line;Cells;Cellular Metabolic Process;Clinical;clinical efficacy;Clinical Trials;Clip;Cryopreserved Cell;Cytomegalovirus;Data;design;Disease;Dose;Eligibility Determination;Environment;Fc Receptor;FCGR3B gene;first-in-human;Frequencies;Gene Modified;Genes;glycogen synthase kinase 3 beta inhibitor;Greater sac of peritoneum;Homing;Human;IgG1;Immune;Immune Evasion;Immunoglobulin G;Immunologics;improved;in vitro testing;in vivo;induced pluripotent stem cell;Infusion procedures;Interleukin-15;Interleukin-2;intraperitoneal;Intravenous;Malignant neoplasm of ovary;Malignant Neoplasms;manufacturing process;manufacturing run;Mediating;Minnesota;Monoclonal Antibodies;monomer;mouse model;Mus;Natural Killer Cells;NK Cell Activation;novel;Ovarian;participant enrollment;patient derived xenograft model;Patients;peripheral blood;Peritoneum;Phenotype;pluripotent stem cell differentiation;pre-clinical;pre-clinical research;Preclinical Testing;Process;progenitor;programs;receptor;Recurrence;Reporting;research clinical testing;response;safety testing;scale up;seropositive;Specificity;synergism;T-Lymphocyte;Testing;Therapeutic;Toxic effect;trispecific killer engager;tumor;Tumor Antigens;tumor microenvironment;Universities;Variant;Woman;Work

PROJECT_TITLE: Locally Targeted Off-The-Shelf NK Cells For Ovarian Cance


NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on identifying mechanisms of detection, resistance and co-option of three food-borne toxins of medical importance: isothiocyanates, cardiac glycosides and cytolethal distending toxins. Although these toxins cause human illness, each is also being used or is in development for treatment of common and debilitating diseases, including Parkinson’s disease, congestive heart failure, and cancer. The proposed research is relevant to that part of the NIH mission that pertains to seeking fundamental knowledge about the nature and behavior of living systems and to that part of the NIGMS mission that supports basic research toward understanding how living systems function across levels of biological organization, from molecules, to cells, tissues, individuals and populations.

PI_NAMEs: WHITEMAN, NOAH K (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Aloral;Animal Model;Animals;base;Basic Science;Behavior;Biological;Biology;Butterflies;Cardiac Glycosides;Cells;common treatment;Congestive Heart Failure;CRISPR/Cas technology;cytolethal distending toxin;Detection;Development;Disease;Drosophila melanogaster;Evolution;flexibility;fly;foodborne;gene editing technology;Genes;Genetic;Genetic Models;genome-wide;Genomics;Goals;Human;Immune;Immune system;in vivo;Individual;interest;Isothiocyanates;Knock-in;Knowledge;Malignant Neoplasms;Mediating;Medical;Mission;Modeling;Mouse-ear Cress;mustard oil;Mutation;National Institute of General Medical Sciences;Natural Selections;Nature;Odorant Receptors;Organism;Parasite resistance;Parasites;parasitism;Parkinson Disease;Pattern;Phase;Plant Model;Population;Process;Proteins;Public Health;Research;Resistance;Shapes;System;therapy development;Tissues;Toxin;transmission process;United States National Institutes of Health;Variant;Volatilization;Walking

PROJECT_TITLE: Co-evolutionary Genetics of Host-Parasite Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Physical Rehabilitation;Rehabilitation

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: RELEVANCE TO PUBLIC HEALTH The Improving Medicare Post-Acute Care Transformation (IMPACT) Act is standardizing the collection of functional outcome data across post-acute providers. This legislation is revolutionizing how post-acute services are being delivered, evaluated, and reimbursed. The K01 research will improve consumer care and contribute to how the IMPACT Act will influence performance on national quality measures such as hospital readmission and discharge to the community.

PI_NAMEs: LI, CHIH-YING  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;acute care;Administrator;Admission activity;Advisory Committees;Agreement;Area;Assessment tool;Attention;Biometry;care systems;career;career development;Caring;Clinical;Cognition;Collection;Communities;Community Health;comparative;Data;Data Collection;Data Element;Data Science;Data Set;data standards;Development;Doctor of Philosophy;Equation;Evaluation;Event;experience;functional outcomes;functional status;Funding;Future;Goals;Grant;Health care facility;Health Policy;Healthcare Systems;Home Health Agency;hospital care;hospital readmission;Impairment;improved;Inpatients;Knowledge;Learning;Logistic Regressions;Long-Term Care;Longitudinal Studies;Measurement;Measures;Medical;Medicare;member;Mentored Research Scientist Development Award;Mentors;Methods;Monitor;Natural experiment;Nurses;Occupational Therapist;Occupational Therapy;Outcome;Outcome Measure;outcome prediction;Outcomes Research;Patient-Focused Outcomes;Patients;Pattern;peer coaching;Performance;Persons;Policy Maker;Preventive Medicine;Productivity;Professional Organizations;professor;programs;Property;Provider;Public Health;Publications;Quality of Care;Rehabilitation Outcome;rehabilitation science;Rehabilitation therapy;rehabilitative care;Reporting;Research;response;Risk;Scientist;Self Care;service delivery;Services;Skilled Nursing Facilities;skills;Standardization;statistics;Statutes and Laws;success;Texas;Time;Training;trend;United States Centers for Medicare and Medicaid Services;Universities;Walking;Writing

PROJECT_TITLE: Standardized Patient Assessment across Post-Acute Care: Opportunities and Challenges

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed work will advance our understanding of the molecular mechanisms by which the oncogene EVI1 protects leukemia cells from chemotherapy. This work will also translate previous findings from in vitro and in vivo models into the context of human EVI1-overexpressing AML and test new treatment regimens using patient- derived xenograft models. Together, these studies will provide the rationale for future clinical trials of treatments that will improve the survival rates of patients with EVI1-overexpressing AML.

PI_NAMEs: AYOUB, EDWARD  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 3q26;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adult Acute Myeloblastic Leukemia;Aftercare;ATAC-seq;Binding;Binding Proteins;Binding Sites;Bone Marrow;CDKN1C gene;Cell Cycle;Cell Line;Cell model;Chemoresistance;chemotherapy;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromosomes;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Complex;Cyclin-Dependent Kinase Inhibitor;Data;data integration;Disease-Free Survival;DNA Binding;Enhancers;EVI1 gene;EZH2 gene;Future;Genes;Genetic Transcription;genomic data;Goals;Granulocyte Colony-Stimulating Factor;Health;Hematopoiesis;hematopoietic stem cell quiescence;Hematopoietic stem cells;Human;improved;In Vitro;in vivo Model;individualized medicine;Inflammatory;inhibitor;insight;knock-down;Laboratories;lambda Spi-1;leukemia;leukemia relapse;Leukemic Cell;Link;Molecular;Molecular Analysis;mouse model;Mus;Myelogenous;Myeloid Progenitor Cells;Myelopoiesis;Myeloproliferative disease;Neoadjuvant Therapy;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;overexpression;Pathway interactions;patient derived xenograft model;Patients;Play;preclinical study;Progression-Free Survivals;Proliferating;Purines;Regulation;Relapse;Research;Research Personnel;response;Role;RUNX1 gene;Sampling;Severities;small hairpin RNA;Stress;Survival Rate;Techniques;Testing;Therapeutic;Training;transcription factor;Transcription Initiation Site;transcriptome sequencing;Translating;Treatment Protocols;treatment response;Up-Regulation;Upstream Enhancer;Work;Xenograft Model

PROJECT_TITLE: Targeting Quiescence Pathways to Overcome Chemoresistance in EVI1-Overexpressing Leukemia


NIH_SPENDING_CATS: Cancer;Immunotherapy;Patient Safety

PHR: The Administrative and Clinical Research Support Core will provide essential support for all administrative activities and clinical trials associated with the program project grant. The administrative components of the core will provide support for accounting, budgeting, fiscal reporting, and communication, while the clinical research support components will facilitate protocol activation and execution as well as effective dissemination of information between Program sites.

PI_NAMEs: MILLER, JEFFREY S. (contact)

PROJECT_TERMS: Accounting;Alleles;Biometry;Budgets;Calendar;Cancer Center;cancer therapy;Cellular biology;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Cohort Analysis;Collaborations;Collection;Communication;Cytomegalovirus;Data;data submission;design;early phase clinical trial;Ensure;Funding;Goals;Grant;human leukocyte antigen testing;Human Resources;Immunogenetics;Immunologic Monitoring;Individual;industry partner;Information Dissemination;Institution;Institutional Review Boards;Interactive Communication;Laboratory Research;Leadership;Link;Maintenance;Marrow;meetings;Minnesota;Monitor;Monitoring Clinical Trials;Multi-Institutional Clinical Trial;Natural Killer Cells;NK cell therapy;Outcome;Participant;Patients;Performance;Persons;Phase;Preparation;Productivity;Program Research Project Grants;programs;Progress Reports;Protocols documentation;receptor;Recommendation;Reporting;Research;Research Personnel;Research Support;Resources;Review Committee;Sampling;Schedule;screening;Services;Site;symposium;synergism;Telephone;timeline;Tissues;Transplantation;United States Food and Drug Administration;United States National Institutes of Health;Universities;Visit;Work


PHR: PROJECT NARRATIVE  Ion transfer across biological membranes is an essential physiological process mediated by ion channels and is central to nerve excitation, muscle cell contraction, signal transduction, and hormone secretion. The immense physiological importance of ion channels is reflected in the fact that their dysfunction underlies a variety of disabling human diseases including seizures, deafness, ataxia, long QT syndrome, and cardiac arrhythmias. We aim to perform structural and functional analyses of eukaryotic organellar cation channels which play important roles in regulating organelle ion concentrations and cytosolic Ca2+ signaling.

PI_NAMEs: JIANG, YOUXING  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Arrhythmia;Ataxia;Award;Biological;Biological Process;biophysical properties;Calcium;calcium uniporter;Cations;Cell Death;Cell membrane;Complex;Cryoelectron Microscopy;Crystallography;cyclic-nucleotide gated ion channels;Cytoplasm;Cytosol;Data;deafness;Defect;design;Disabling;Electrophysiology (science);Endosomes;Functional disorder;Gatekeeping;Homeostasis;Hormone secretion;Human;human disease;Inner mitochondrial membrane;insight;interest;Ion Channel;Ions;Lipids;Long QT Syndrome;Lysosomal Storage Diseases;Lysosomes;Measures;Mediating;Membrane;Metabolism;Mitochondria;Muscle Contraction;Nerve;Organelles;particle;Physiological;Physiological Processes;Physiology;Play;Potassium Channel;Process;Production;Property;protein complex;Proteins;Recording of previous events;Regulation;Research;Research Personnel;Role;Seizures;Signal Transduction;three dimensional structure;trafficking;TRP channel;uptake;Work

PROJECT_TITLE: Structural and Functional Studies of Organellar Ion Channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The goal of this research program is to gain detailed mechanistic insight into retrotransposition and pre-mRNA splicing. Retroelements and spliceosomal introns comprise ~70% of the human genome and defects in their function results in many human diseases. We aim to use the molecular insight into these essential genetic mechanisms as a foundation for the development of RNA therapeutics.

PI_NAMEs: TOOR, NAVTEJ SINGH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Active Sites;Biochemical;Catalysis;Catalytic RNA;Complex;Cryoelectron Microscopy;Defect;Development;DNA;Eukaryota;Excision;Exhibits;Exons;Foundations;Future;Genetic;genetic element;Genome;Goals;human disease;Human Genome;In Vitro;insight;Introns;Investigation;Knowledge;Ligation;Location;Molecular;mRNA Precursor;Nucleotides;particle;Paste substance;Prevalence;programs;Proteins;Reaction;Research;Resolution;Retroelements;Retrotransposition;Ribonucleoproteins;RNA;RNA Splicing;RNA-Directed DNA Polymerase;single molecule;Spliceosomes;structural biology;Structure;System;therapeutic RNA;thermostability;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Biology of Retrotransposition and pre-mRNA Splicing


NIH_SPENDING_CATS: Cancer

PHR: The primary objective of the Biostatistics Core B is to contribute to the science and operation of the program project by participating fully in its activities as it has for the preparation of this application. This includes assistance and direction in experimental design, data collection and management, quality control, statistical data analysis, and interpretation of findings through consultation and collaboration; inventing and incorporating new and novel procedures as needed.

PI_NAMEs: LE, CHAP T. (contact)

PROJECT_TERMS: Acceleration;Animals;Basic Science;Biometry;Biostatistics Core;Cancer Center;cancer therapy;Clinical;Clinical Trials;Collaborations;Consultations;cost effectiveness;Data;Data Analyses;Data Collection;data management;design;Development;Ensure;Ethics;experience;Experimental Designs;experimental study;Future;Genetic;Information Systems;interdisciplinary approach;invention;member;Methodology;Methods;Minnesota;Monitor;Natural Killer Cells;novel;operation;pre-clinical;Preparation;Procedures;Process;programs;Public Health;Publications;quality assurance;Quality Control;receptor;Reporting;Research;Research Personnel;Research Support;Resources;Science;Secure;Societies;sound;Statistical Data Interpretation;statistics;Survival Analysis;Translations;trial design;Universities

PROJECT_TITLE: Biostatistics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH Nearly 20% of women in the U.S. (1 million women per year) experience clinically significant depressive symptoms during pregnancy or postpartum, and the majority of these women suffer “in silence” due to various barriers to care. A promising internet-based approach for preventing perinatal depressive symptoms, “Mamma Mia”, has been developed and tested in Norway; we propose to build upon this work by evaluating an adapted version through a multi-site randomized controlled trial in a large group of diverse women in the U.S. If successful, the proposed project has high potential to change self-management of perinatal depressive symptoms because it is practical, internet-based, and low-cost.

PI_NAMEs: KINSER, PATRICIA ANNE (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Adherence;adherence rate;Age;Anxiety;Arizona;arm;barrier to care;Behavior;Belief;biobehavior;Birth;Breast Feeding;Child;Child Development;Clinical;clinically significant;comorbidity;coping;cost;depressive symptoms;design;Development;disorder prevention;Economic Burden;Education;Effectiveness;Emotional;Emotions;Enrollment;Ethnic Origin;evidence base;experience;Family;Geographic Locations;Goals;health management;Health Personnel;Health Promotion;Healthcare;Human;Impairment;improved;Individual;Infant;Informal Social Control;interest;Internet;Intervention;intrinsic motivation;Low Birth Weight Infant;Maternal and Child Health;Measures;Mediating;Mediator;Medical Care Costs;Mental Health;Monitor;National Institute of Child Health and Human Development;neonatal outcome;Norway;novel;Nursing Research;Outcome;Parents;parity;perinatal depressive symptom;perinatal intervention;perinatal women;Personal Satisfaction;postpartum care;Postpartum Depression;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Premature Birth;prenatal;prevent;Prevention;Prevention strategy;primary outcome;programs;Public Health;Qualifying;Race;racial diversity;Randomized;randomized, controlled study;Randomized, Controlled Trials;recruit;Registered nurse;Research Priority;Resources;retention rate;secondary outcome;Self Efficacy;Self Management;self-management program;Self-reflection;Severities;Site;skills;Social Perception;social stigma;Social support;societal costs;Societies;Socioeconomic Status;socioeconomics;Stress;study population;suicidal;symptom self management;Symptoms;Testing;theories;Time;treatment as usual;United States;Universities;Virginia;Woman;Work

PROJECT_TITLE: A multisite randomized controlled trial of an internet-based program for preventing and reducing perinatal depressive symptoms

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Breast cancer mortality disparities remains an important public health and clinical challenge. Understanding breast cancer recurrence is a critical target in reducing disparities, but a lack of population-based data limit inferences. The proposed study will advance our understanding of multi-level drivers of demographic disparities in recurrence and breast cancer-specific mortality, and facilitate prioritization of intervention targets.

PI_NAMEs: MCCULLOUGH, LAUREN E (contact)

PROGRAM_OFFICER_NAME: CRONIN, KATHLEEN A

PROJECT_TERMS: Accounting;Adopted;Affect;Area;Black Populations;Black race;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer survivor;cancer health disparity;Cancer Prognosis;cancer recurrence;cancer survival;Caring;Cells;Censuses;Characteristics;Clinical;Clinical Data;Clinical Research;Communities;Data;data registry;data streams;Death Rate;demographic disparity;demographics;Diagnosis;Disease;Disparate;Disparity;disparity reduction;Distal;Distant;Early Diagnosis;economic disparity;Epidemiologic Methods;ethnic disparity;Ethnic Origin;Event;evidence base;experience;Funding Opportunities;Guidelines;high risk;Hospitals;improved;Individual;Inequity;innovation;Institution;intersectionality;Intervention;Investigation;lifetime risk;Low income;low socioeconomic status;Malignant Breast Neoplasm;Mediating;Mediator;Minority;mortality;mortality disparity;multidisciplinary;multilevel analysis;neoplasm registry;Nonmetastatic;Not Hispanic or Latino;Outcome;outcome disparities;Outcomes Research;Pathway interactions;Pattern;Policies;Population;population based;Population Heterogeneity;Population-Based Registry;Positioning Attribute;Prevalence;Prognosis;Public Health;Race;racial determinant;racial disparity;Recurrence;Research;Risk Estimate;Role;Rural;rural disparities;rural residence;Social Environment;social epidemiology;Societies;Source;Statistical Methods;survival disparity;Survivors;Time;Tumor Biology;United States;Woman;women's diagnosis;Women's mortality;Work

PROJECT_TITLE: Improving our understanding of breast cancer mortality disparities through recurrence: a multi-level approach among women in Georgia

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: This grant focuses on clinical implementation of novel NK targeted therapeutics and third-party NK cell products in a variety of cancer settings. Core C will serve all of the projects by uniformly integrating sample processing and state-of-the-art analytics for all clinical trials carried out in this grant. The resulting high-quality data will be linked to clinical outcomes, in collaboration with Cores A and B, and presented to Project 1, 2, and 3 leaders.

PI_NAMEs: FELICES, MARTIN  (contact)

PROJECT_TERMS: Allogenic;Biological Assay;Cancer Center Support Grant;cancer therapy;Cell Physiology;Cells;Cellular biology;Clinical;Clinical Data;clinical implementation;Clinical Trials;Collaborations;cytokine;cytokine release syndrome;Cytometry;Data;Databases;Dose;Drug Kinetics;Effector Cell;Evaluation;Funding;graft vs host disease;Grant;Histologic;Image;Immune;immune function;immune reconstitution;immunogenicity;Immunologic Monitoring;Immunotherapeutic agent;Immunotherapy;improved;Individual;Inflammatory;Infusion procedures;Intervention;Laboratories;Link;Lymphoma;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Methodology;migration;Natural Killer Cells;neoplastic cell;neutralizing antibody;novel;Outcome;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;Process;programs;Quality Control;receptor;recruit;Reproducibility;Resource Sharing;Sampling;Standardization;synergism;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;Tissues;translational therapeutics;tumor;tumor microenvironment;Variant

PROJECT_TITLE: Immune Monitoring and Tissue Analysis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative A significant number of pregnancies fail at very early stages in embryonic development for reasons that have been difficult to ascertain due to limitations in studying human development. We propose to investigate the developmental mechanisms the human embryo uses at these early stages to pattern its initial form through an innovative combination of micron-scale stem cell engineering technologies and optogenetic tools, that enable the systematic variation of the signaling patterns thought to drive human embryonic pattern formation. In addition to understanding these mechanisms, enhanced control of natural patterning mechanisms of human stem cells promises to boost the efficiency and precision of engineered tissues for regenerative medicine.

PI_NAMEs: WILSON, MAXWELL ZANE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Adult;algorithm development;Amniotic Sac;Anterior;beta catenin;Biochemistry;Biology;biomaterial compatibility;bioprinting;Cell Count;Cell Line;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Coupling;Development;Dissection;Dorsal;Ectoderm;Embryo;Embryo Research;Embryonic Development;Embryonic Pattern Specification;engineered stem cells;Engineering;Environment;Epiblast;Ethics;Event;extracellular;Failure;fluorescence imaging;Frequencies;gastrulation;Genes;Genetic;Genetic Transcription;Genome;Germ Layers;Human;Human body;Human Development;human embryonic stem cell;Human Engineering;human model;human stem cells;human tissue;Image;implantation;inhibitor;innovation;insight;Laboratories;Lead;Ligands;Light;Maps;Mesoderm;model organism;Modeling;Molecular;Noise;Optics;optogenetics;Pathway interactions;Pattern;Pattern Formation;Physics;Positioning Attribute;Pregnancy;pregnancy failure;Pregnancy loss;Process;Regenerative Medicine;Reporter;Resolution;Role;Signal Pathway;Signal Transduction;Signaling Protein;spatiotemporal;Specific qualifier value;stem cell derived tissues;stem cell model;stem cells;Stereotyping;Structure;Technology;three-dimensional modeling;Time;Tissue Engineering;Tissues;tool;transmission process;Variant;Visualization;WNT Signaling Pathway

PROJECT_TITLE: Optical dissection of human embryonic germ layer patterning mechanisms using microengineered stem cell models

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

PHR: Bipolar androgen therapy (BAT) is a promising new strategy to treat prostate cancer patients that have developed metastatic castration-resistant disease and would otherwise be left with no other therapeutic options. We have found that BAT induces the expansion of monocytic-myeloid derived suppressor cells (M-MDSCs) in patients who do not respond to this treatment and hypothesize that these cells could be partly responsible for limiting its efficacy. We propose to use new high resolution technologies to study these cells in 2 cohorts of patients exposed to BAT, coupling this to the use of animal models of prostate cancer, to determine if targeting M-MDSCs in combination with BAT might form the basis of a future approach to boost therapeutic efficacy.

PI_NAMEs: DENMEADE, SAMUEL R;SANIN PENA, DAVID ESTEBAN (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: advanced disease;advanced prostate cancer;Affect;Aftercare;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Therapy;Androgens;Animal Model;anti-tumor immune response;arginase;Biochemical;Biological Assay;Biopsy;Cancer Patient;Castration;Cell Physiology;Cells;Cellular biology;Cessation of life;Clinical;Clinical Trials;cohort;Computational Biology;Conceptions;Coupling;cytokine;Data;data integration;Data Set;design;Discipline;Disease;Disease Resistance;Effectiveness;Endotoxic Shock;Engraftment;enzalutamide;Exposure to;Expression Profiling;Flow Cytometry;Fluorouracil;Future;Gene Expression;Gene Expression Profile;high dimensionality;Human;Immune;Immune system;Immune Tolerance;Immunity;Immunologic Markers;Immunosuppression;improved;In Vitro;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innovative Therapy;Interleukin-10;Left;Literature;Lung;Macrophage;Malignant neoplasm of prostate;Mediating;Modeling;monocyte;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;next generation sequencing;Nivolumab;Non-Malignant;novel strategies;Oncology;Outcome;palliative;participant enrollment;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Population;Predisposition;programmed cell death protein 1;programs;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;protein expression;Publishing;Quality of life;radiological imaging;receptor expression;Resistance;Resistance development;resistance mechanism;Resolution;response;Role;Serum;Sex Differences;single-cell RNA sequencing;standard of care;success;T-Lymphocyte;targeted treatment;Technology;Testing;Testosterone;Therapeutic;Toxic effect;transcriptome sequencing;Transforming Growth Factor beta;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Immunity;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Up-Regulation

PROJECT_TITLE: The Role of Myeloid-Derived Suppressor Cells in Resistance to Bipolar Androgen Therapy in Patients with Advanced Prostate Cancer


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Moral Injury (MI) is defined as the lasting psychological, biological, spiritual, behavioral, and social impact of perpetrating, failing to prevent, bearing witness to, or being the victim of acts that transgress deeply held moral beliefs and expectations. Until recently, there has been no gold standard measure of MI and no information about the extent of this problem among Veterans. This proposal entails the first national representative epidemiological survey study of reports of exposure to potentially morally injurious events, and the extent of MI in US Veterans. Because there is no way to define clinical cases of MI, we will use the survey results to generate a cut-score on a new gold standard measure of MI that indicates clinically impairing levels of MI symptoms and report the prevalence of such cases. We will also determine the clinical value of MI, relative to PTSD and Depression, in explaining functional problems in Veterans. Finally, we will interview a random set of MI cases and controls to examine risk and resilience and the clinical care needs of Veterans with MI.

PI_NAMEs: LITZ, BRETT T (contact)

PROJECT_TERMS: Affect;base;Behavioral;behavioral health;Belief;Biological;Clinical;Clinical assessments;clinical care;Clinical Research;clinically significant;Code;Communities;Consensus;Data;design;Dimensions;Distress;Epidemiology;epidemiology study;Event;expectation;experience;Exposure to;Frustration;Functional impairment;Household;Human;Impairment;interest;Internet;Interview;Knowledge;Measurement;Measures;Mental Depression;Mental Health;Methods;Military Personnel;military veteran;Modernization;Moral injury;Morals;Outcome;Population;population based;Post-Traumatic Stress Disorders;Prevalence;Prevalence Study;prevent;Prevention;Probability;protective factors;psychologic;Psychometrics;Quality of life;Questionnaires;Random Allocation;recruit;repaired;Reporting;Research;Research Personnel;resilience;response;Risk;Risk Factors;ROC Curve;Sampling;service member;Severities;Shame;social;Social Impacts;sound;Spirituality;standard measure;stem;stressor;Surveys;Symptoms;Syndrome;Testing;Time;Trust;Vacuum;Veterans;Weight;Work

PROJECT_TITLE: The Prevalence and Functional Impact of Moral Injury in Veterans

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Endocrine Disruptors;Genetics;Human Genome;Liver Disease;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Neonatal thyroid hormone signaling in the liver modifies the future susceptibility to liver steatosis and obesity. We discovered that this is explained by differential DNA methylation that affects how genes are expressed in the adult liver. Here we will explore how the neonatal peak of thyroid hormone signaling affects DNA methylation and their physiological consequences.

PI_NAMEs: BIANCO, ANTONIO C (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Adult;Affect;Area;Brown Fat;Chromatin;chromatin remodeling;Chromatin Structure;Chromosome 4;chromosome conformation capture;Cochlea;Data;Development;DNA;DNA Methylation;Embryo;Enhancers;Enzymes;Epigenetic Process;Exhibits;fascinate;Fatty Liver;Funding;Future;Gene Expression;gene repression;Gene Silencing;Genes;genetic corepressor;Genetic Transcription;Genome;Hepatic;Hepatocyte;Heterochromatin;hormonal signals;hormone metabolism;Human;Hyperlipidemia;Hypermethylation;Iodide Peroxidase;knock-down;Learning;lipid metabolism;Liver;liver development;Mediating;Metabolic;Methylation;Mus;Neonatal;novel;Obesity;Organ;Organoids;Perinatal;Phenotype;Physiologic pulse;Physiological;Plasma;Play;postnatal;Predisposition;prevent;Production;promoter;Protein Isoforms;Role;Shapes;Signal Transduction;Site;Thyroid Crisis;Thyroid Hormone Receptor;Thyroid Hormones;Time;Tissues;transcriptome;transcriptome sequencing;Triiodothyronine;Xenobiotics

PROJECT_TITLE: Metabolic and xenobiotic control of thyroid hormone metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Lung;Organ Transplantation;Transplantation

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Lung tissue removed for transplantation currently cannot be preserved for more than 8 hours, and even then, damage to the lung tissue likely contributes to the low survival rate following lung transplantation (50% of patients do not survive more than 5 years). Our studies seek to improve lung tissue preservation and transplant outcomes; we will test using a liver cell bioreactor to improve lung tissue metabolism and reduce inflammation while the lungs are being transported for transplantation. Ultimately, our work will address current limitations in lung transplantation by helping to extend donor organ transportation time and distance beyond 8 hours and to improve post-transplant patient survival.

PI_NAMEs: GERLACH, JOERG C.;SANCHEZ, PABLO G (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Biochemical;Biological;Biomedical Engineering;Bioreactors;Blood specimen;Cadaver;cell injury;Cell Physiology;Cells;Chronic;Circulation;clinically significant;Conditioned Culture Media;Cross Circulation;Cryopreservation;cytokine;Cytokine Signaling;Data;Drug Metabolic Detoxication;Endothelium;Experimental Models;experimental study;Family suidae;Genetic;Genetic Transcription;graft dysfunction;Hepatic;Hepatocyte;Histologic;Hour;Human;human model;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;inhibitor;Injury;Intervention;Investigation;Ischemia;liver function;liver injury;Lung;lung preservation;Lung Transplantation;Measures;Metabolism;Mitochondria;Modeling;mortality;National Heart, Lung, and Blood Institute;Nuclear;Organ;Organ Donor;Outcome;Patients;Perfusion;pharmacologic;Phenotype;Play;post-transplant;preservation;pulmonary function;Rattus;Reaction;receptor for advanced glycation endproducts;Regulation;Research;response;Resuscitation;Risk;Risk Factors;Role;Running;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;Survival Rate;Technology;Testing;Time;Tissue Preservation;Tissue Transplantation;Tissue Viability;Tissues;transplant model;Transplant Recipients;Transplantation;Transportation;United States National Institutes of Health;usability;Vascular Endothelium;ventilation;Waiting Lists;Work

PROJECT_TITLE: Incorporating hepatic cell function into lung ex vivo lung perfusion for transplant preservation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Rare Diseases;Sexually Transmitted Infections

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Herpes simplex virus type 1 induced corneal stromal keratitis (HSK) is a leading infectious cause of blindness. This proposal has the potential to define, for the first time, an important contribution of the factor, Sterile alpha and TIR motif containing 1 (SARM1), and in so doing so identify a new target(s) for therapy.

PI_NAMEs: ST LEGER, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: adeno-associated viral vector;Affect;afferent nerve;Alzheimer's Disease;Anti-viral Agents;Architecture;Axon;axon growth;Back;Blindness;blink reflexes;Bone Marrow;CD4 Positive T Lymphocytes;Cell Maturation;Cells;Chimera organism;Cornea;Corneal Opacity;cytokine;Data;Desiccation;Development;Diabetic Neuropathies;Disease;effective therapy;Exposure to;Flow Cytometry;Ganglia;Generations;Genes;Goals;Growth;Health;Herpes Simplex Infections;Herpes stromal keratitis;Herpesvirus 1;Herpetic Keratitis;Human;Immune;Immune response;Immunity;immunodeficiency;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integration Host Factors;Invaded;Keratitis;Lead;Life;Link;Measures;Metabolism;migration;Modality;Modeling;Monitor;monocyte;Mus;Myelogenous;Myeloid Cells;Nature;Nerve;Nerve Degeneration;Neuroimmune;Neurons;novel;Parkinson Disease;Pathogenesis;Pathology;Persons;Play;Population;preclinical study;prevent;Process;Production;Publishing;Recurrence;response;Role;Sensory;Sensory Nerve Endings;Simplexvirus;Sterility;Steroids;Stress;Structure of trigeminal ganglion;symptom treatment;T-Lymphocyte;Testing;Therapeutic;Time;Traumatic Brain Injury;Travel;Vaccines;Vascular Endothelial Growth Factors;VEGFA gene;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Contribution of sympathetic nerves to herpes stromal keratitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative/Relevance Statement Our studies will make important contributions to help clarify the mechanisms of centromere maintenance and specify the role of EWSR1 in centromere function and chromosome segregation, which will lead to insights relevant to health and disease, including cancer, birth defects, and developmental disorders such as Down syndrome.

PI_NAMEs: KITAGAWA, KATSUMI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Auxins;Binding;Biochemical;Cell Cycle;Cell Cycle Stage;Cell division;Cells;Centromere;centromere protein A;Chimeric Proteins;Chromatids;Chromatin;Chromosomal Instability;Chromosome Segregation;Chromosomes;Congenital Abnormality;Data;daughter cell;Defect;Deposition;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA Sequence;Down's Syndrome;Engineering;Ensure;Ewings sarcoma;EWSR1 gene;FLI1 gene;Functional disorder;G1 Phase;Goals;Health;Histone H3;Human;Hybrids;Impairment;insight;Interphase;Kinetochores;Maintenance;Malignant Neoplasms;Mammals;Microtubules;Mitosis;Modeling;Molecular Chaperones;mutant;Mutation;Nucleosomes;Oncogenic;Phase;Phenotype;Play;prion-like;protein complex;Proteins;RNA;RNA Binding;RNA Recognition Motif;Role;segregation;SETX gene;Signal Transduction;Sister Chromatid;Specific qualifier value;Specificity;Structure;System;TAF15 gene;Testing;transmission process;Variant

PROJECT_TITLE: The role of EWSR1 at the centromere

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]