ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Acquired resistance to therapy contributes to poor survival outcomes in cancer patients. The primary objective of this U54 application is to establish a successful and self-sustaining ARTNet Center for Pancreatic Cancer (ACPC) to explore novel mechanisms and combination therapies to target acquired resistance in pancreatic cancer. We will collaborate and work closely with other ARTNet centers, coordinating center, and the National Cancer Institute to provide novel mechanistic insights and translational opportunities to target therapy resistance with the long-term goal of improving overall patient survival.

PI_NAMEs: SINGH, PANKAJ KUMAR (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Advisory Committees;Biological Assay;cancer cell;Cancer Center;Cancer Patient;cancer therapy;Caring;Cells;Chemoresistance;chemotherapy;Circulation;Clinic;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Companions;CRISPR screen;Data;Data Coordinating Center;Dedications;design;Development;Disease;Educational workshop;effective therapy;environmental stressor;Epigenetic Process;exosome;Exposure to;Fostering;Goals;Growth;human model;Immune;improved;innovation;insight;Institution;Intercellular Fluid;Investigation;Knowledge acquisition;Leadership;lectures;Libraries;lipidomics;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;meetings;member;Metabolic;metabolic phenotype;metabolomics;Methods;Mission;Modification;National Cancer Institute;neoplastic cell;novel;novel therapeutics;Outcome;Paclitaxel;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;patient prognosis;Patients;preclinical efficacy;prevent;Primary Neoplasm;Prognosis;programs;Proteins;Recording of previous events;Research;Resistance;resistance mechanism;Resource Sharing;Resources;response;Role;Sampling;Science;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;sound;stable isotope;standard of care;Stromal Cells;Stromal Neoplasm;survival outcome;symposium;synergism;System;targeted treatment;Technology;Therapeutic;therapy resistant;tissue resource;tool;translational potential;translational study;Translations;treatment response;tumor metabolism;Validation;web site;Work

PROJECT_TITLE: Cancer and stromal metabolic reprogramming drives chemotherapy resistance in human models of pancreatic cancer


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Pediatric;Rare Diseases

ORG_CITY: San Diego

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: STARLIGHT CARDIOVASCULAR, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many babies born with Congenital Heart Disease (CHD) require surgical intervention within days of life to survive. Surgery is invasive and can require putting the baby on a heart-lung bypass machine, which can have negative consequences. Starlight Cardiovascular will develop the first branch pulmonary artery flow restrictors designed specifically for babies with CHD that can be delivered minimally-invasively through a catheter, which could replace surgery and improve patient outcomes with an increased safety profile.

PI_NAMEs: TANG, BEVERLY  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Acute;Address;Administrative Supplement;Animals;Beds;Blood flow;Blood Vessels;Cardiopulmonary Bypass;Cardiovascular system;Catheters;Childhood;Chronic;Circulation;Clinical;Clinical Research;commercialization;Communication;congenital heart abnormality;design;Development;Device Designs;Devices;Equilibrium;FDA approved;Grant;Growth;Hand;heart defect;Hypoplastic Left Heart Syndrome;Implant;implant design;improved;interest;Intervention;Label;Length;Life;Lung;migration;minimally invasive;neonatal patient;Newborn Infant;Operative Surgical Procedures;Patient-Focused Outcomes;Perforation;Phase;Physiological;Pulmonary Artery Branch;Pulmonary artery structure;repaired;Resistance;Rest;Safety;Small Business Innovation Research Grant;Testing;Thoracic Surgical Procedures;Truncus Arteriosus;Ventricular Septal Defects;verification and validation

PROJECT_TITLE: Administrative Supplement to Promote Diversity in MedTech Through Development of Pulmonary Flow Restrictors


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE - OVERALL Glioblastoma is a deadly primary brain tumor, and there has been almost no progress in developing effective therapies for this disease over the past 2 decades. The MIT/DFCI Center for Systems Biology of Glioblastoma will use sophisticated techniques to better understand how growth of these tumors specifically within the brain affects treatment response and to use this knowledge to develop more effective therapies for this deadly disease.

PI_NAMEs: MICHOR, FRANZISKA ;WHITE, FOREST M (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adaptive Immune System;Address;Affect;Biological Models;Biopsy;Brain;career;cell type;Cells;Clinic;Collaborations;Complex;Computer Models;Cytotoxic Chemotherapy;Data;Development;Disease;driving force;dynamical evolution;effective therapy;Environment;Fostering;Foundations;Glioblastoma;Glioma;Goals;graduate student;Growth;Human;image registration;Immune;immune cell infiltrate;Immune Targeting;Immunooncology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Innate Immune System;insight;Invaded;Knowledge;Lead;Malignant Neoplasms;Massachusetts;medical schools;Mentorship;migration;Modeling;Modernization;Molecular;multi-scale modeling;multiple omics;Nature;Necrosis;neoplastic cell;neural;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurons;neurotransmission;next generation;novel;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;outreach;Pathway interactions;Patient Care;Patients;Phase 0 Clinical Trial;Phenotype;Phosphoproteins;predictive modeling;Primary Brain Neoplasms;programs;Proteins;Radiation therapy;Research;Research Project Grants;Resistance;response;Sampling;Secondary to;Signal Transduction;Stimulus;System;Systems Biology;targeted treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Transcript;treatment response;tumor;tumor behavior;Tumor Biology;Tumor Burden;Tumor Cell Biology;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Universities

PROJECT_TITLE: Impact of immune-targeting therapies on the GBM tumor immune interface


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: Project Narrative The proposed ITN UM1 funding addresses major unmet health needs. In the United States, autoimmune diseases affect >5% of the population, and allergic diseases affect another ~15%. Transplantation is a life- saving intervention for organ failure, but risky and burdensome. In each area, pre-clinical studies show that immune tolerance should be an achievable therapeutic prospect, and progress towards that goal is evident in recent clinical trials. Successful tolerance offers long-term freedom from immunosuppressive therapy, radically improving quality of life, disease burden, and health care costs. Sunbeam specific activities are being performed in support of CoFAR. 1 Abstract

PI_NAMEs: ANDERSON, MARK S;BUCKNER, JANE HOYT (contact)

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Allergic Disease;Area;Autoimmune Diseases;Autoimmunity;burden of illness;California;clinical application;Clinical assessments;Clinical Research;clinical research site;Clinical Trials;data sharing;design;Development;Discipline;Disease;Freedom;Funding;Future;Genetic;Goals;Health;Health Care Costs;Hypersensitivity;Immune Tolerance;Immunologics;Immunology;improved;innovation;Institution;Intervention;Knowledge;Laboratories;Lead;Leadership;Life;Medical;Mission;next generation;novel;operation;Organ failure;Population;preclinical study;Process;programs;Quality of life;Research Institute;Research Personnel;Resource Sharing;Role;San Francisco;Structure;Therapeutic;Therapeutic immunosuppression;Transplantation;treatment response;trial planning;United States;Universities

PROJECT_TITLE: Immune Tolerance Network: SUNBEAM Multi-year Supplement


ADMINISTERING_IC: OD

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Precision Medicine

PROJECT_TERMS: Advisory Committees;Advocate;Agreement;All of Us Research Program;Biomedical Research;cohort;Data;Data Aggregation;data quality;design;Disease;Evaluation;experience;Goals;handheld mobile device;Health;health administration;Health Personnel;Healthcare;Individual;Knowledge;Mediator;Modeling;Observational Study;Participant;patient engagement;precision medicine;preference;programs;Provider;Quality Control;Research;Source;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans Health Administration;volunteer;wearable device;working group

PROJECT_TITLE: IAA between the Department of Veterans Affairs (VA) Veterans Health Administration (VHA) and National Institutes of Health (NIH) - Palo Alto


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: CARSON, DENNIS  (contact)

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Antigens;Award;B-Lymphocytes;Cells;Contractor;Formulation;Human;Immunologic Memory;Innate Immune System;Ligands;liposomal formulation;Liposomes;novel;pathogen;Research;response;scale up;small molecule;T-Lymphocyte;TLR4 gene;Vaccines

PROJECT_TITLE: TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Suicide;Violence Research;Youth Violence

ORG_NAME: EVIDENCE-BASED PRACTICE INSTITUTE, INC.

PHR: PUBLIC HEALTH STATEMENT Behavioral health problems, including substance use disorders, non-suicidal self-injurious behaviors (NSSI) and suicidal behaviors (ideation, planning, attempts) have significantly increased in teens over the past two years as a result of COVID. Black youth and indigenous youth are particularly vulnerable to suicide and substance use disorders. For example, rates of suicidal behavioral and death by suicide among Black youth have risen at an alarming rate and faster than other; and suicide rates the highest among indigenous youth. iKinnect is an efficacious paired mobile app platform that supports parents (in delivering) and youth (in receiving) evidence-based techniques to reduce youth problem behaviors. This proposed fast-track seeks to adapt iKinnect to reduce substance use disorders while also preventing NSSI, suicidal behaviors (ideation, planning, attempts), and death by suicide among teens, including Black and indigenous youth.

PI_NAMEs: DIMEFF, LINDA A (contact);SCHAEFFER, CINDY M.

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: active control;Address;Adolescent;adolescent substance abuse;Affect;Age;Behavioral;behavioral health;Black race;Caregiver support;Caring;Child Rearing;children of color;Cognitive Therapy;commercialization;commercialization readiness;comorbidity;comparison control;Conduct Disorder;conduct problem;coping;cost effective;COVID-19;design;design,build,test;Development;digital technology;Disease;Distress;Early Intervention;Effectiveness;Ensure;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;externalizing behavior;Family;Family psychotherapy;Feedback;formative assessment;General Population;Health;health disparity;ideation;improved;Indigenous;Intervention;iterative design;juvenile justice system;Manuals;Marketing;Measures;Medical Device;meetings;Mental Health;Methods;mobile application;mobile computing;novel;opioid overdose;Outcome;Parents;Participant;peer support;Phase;pilot test;Population;prevent;Problem behavior;Procedures;Process;prototype;Public Health;Randomized, Controlled Trials;Readiness;recruit;reduced substance abuse;reduced substance use;Regulatory Pathway;Reporting;Research;Risk Behaviors;Sales;satisfaction;Self-Injurious Behavior;Services;smartphone application;Specialist;Stress;stressor;Substance abuse problem;substance abuse treatment;substance misuse;substance use;Substance Use Disorder;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;suicide rate;Symptoms;Systemic Therapy;Techniques;Technology;Teenagers;Testing;trial design;United States Food and Drug Administration;user centered design;Youth

PROJECT_TITLE: iKinnect Mobile Technology to Reduce Teen Substance Misuse and Health Disparities


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: JHU Uganda CTU Administrative Supplement Narrative Yr 18 The purpose of this administrative supplement request for UM AI-069530 is to request much needed infrastructure funding to support the JHU Uganda CTU and its two CRSs in Kampala Uganda: The Baylor Uganda and the MUJHU CRS. These requested funds for the two CRSs will support staff training, much needed equipment and supplies; as well as internet capability and pharmacy and clinic facility infrastructure. The requested travel funds for the JHU Uganda CTU will allow for one extra international trip by JHU CTU staff to provide on the ground technical assistance focused on completion of remote monitoring training and launching of new protocols over the next 7 months, as well to allow participation of one additional JHU staff member in the HIV network meetings being held in June, and September 2024.

PI_NAMEs: FOWLER, MARY GLENN (contact);MUSOKE, PHILIPPA ;TOBIAN, AARON A

PROGRAM_OFFICER_NAME: TUCKER, JENESE

PROJECT_TERMS: Active Sites;Address;Adherence;Administrative Supplement;AIDS clinical trial group;Baltimore;behavioral study;Clinic;Clinical;clinical research site;Clinical Trials Unit;Complex;District of Columbia;Emerging infection;Equipment and Supplies;Funding;HIV;HIV prevention trial;HIV prevention trials network;Hospitals;immunotherapy trials;improved;Infrastructure;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Internet;meetings;member;Mentors;next generation;Pharmacy facility;pre-exposure prophylaxis;Pregnancy;Prevention trial;Prophylactic treatment;Protocols documentation;remote monitoring;Research;Research Personnel;Site Visit;support network;Training;Travel;treatment trial;Uganda;United States National Institutes of Health;Universities;Update;vaccine trial

PROJECT_TITLE: The Johns Hopkins University - Uganda Clinical Trials Unit


NIH_SPENDING_CATS: Bioengineering;Lung;Nanotechnology;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PHR: PROJECT NARRATIVE Supplemental oxygen and mechanical ventilation used in premature infants causes lung vascular remodeling and pulmonary hypertension. Our proposed studies will elucidate the metabolic mechanisms underlying endothelial-mesenchymal transition during the development of pulmonary hypertension using lamb and mouse models of bronchopulmonary dysplasia. This research will have significant translational potential for the development of novel pharmacological approaches targeting fatty acid metabolism or endothelial-mesenchymal transition to prevent pulmonary hypertension in patients with bronchopulmonary dysplasia.

PI_NAMEs: YAO, HONGWEI  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Adolescence;Adult;Affect;Alveolar;Attenuated;Blood Vessels;Bronchopulmonary Dysplasia;Cardiovascular system;Carnitine;Carnitine Palmitoyltransferase I;Cell Differentiation process;Cells;clinically relevant;cost;curative treatments;Data;Development;Disease;Disease Management;Endothelial Cells;Endothelium;Enzymes;Exposure to;fatty acid metabolism;fatty acid oxidation;Fetal Lung;Gene Expression;Goals;Hospitalization;Human;Hyperoxia;Infant;innovation;Innovative Therapy;Knockout Mice;lamb model;Levocarnitine;long chain fatty acid;Lung;Mechanical ventilation;Mediating;Mesenchymal;Metabolic;Metabolism;Mitochondria;Molecular;mouse model;Mus;nanoparticle;nanoparticle delivery;Neonatal Hyperoxic Injury;neonatal mice;neonate;new therapeutic target;Newborn Infant;novel;novel therapeutics;oxidation;Oxygen;Pathogenesis;Pathogenicity;Patients;pharmacologic;Play;Predisposition;Premature Infant;premature lungs;prevent;primary pulmonary hypertension;Proliferating;Protein Acetylation;Publications;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;reduce symptoms;Reporting;Research;Rodent Model;Role;Smooth Muscle Myocytes;success;Survivors;System;Testing;therapeutic target;transdifferentiation;translational potential;Up-Regulation;vascular smooth muscle cell migration;Vasodilator Agents

PROJECT_TITLE: Metabolic mechanisms underlying bronchopulmonary dysplasia-associated pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Orphan Drug;Pediatric;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative SADBE produces complete regression of congenital melanocytic nevi alongside robust inflammation in mouse models. We aim to optimize this treatment (alone or in combination with other small molecules) to accomplish maximum nevi regression with minimum (or no) inflammation, obtain treatment for this morbidity-prone devastating childhood condition, and avoid debilitating surgeries.

PI_NAMEs: FISHER, DAVID E (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Acids;adaptive immunity;Adult;Agonist;Anguish;Animal Model;Anti-Inflammatory Agents;anti-PD-1;Binding;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Child;Childhood;Clinical Trials;Complement;Congenital melanocytic nevus;constitutive expression;Cutaneous;Deformity;Dermatology;Dose;effector T cell;Engineering;Esters;Excision;Exhibits;Funding;Genetic;Genetically Engineered Mouse;giant congenital nevus;Goals;Haptens;Histology;Human;human disease;Hyperpigmentation;Imiquimod;Immunity;immunodeficiency;Immunodeficient Mouse;Individual;inducible Cre;inducible gene expression;Inflammation;Inflammatory;inhibitor;Institutional Review Boards;kinase inhibitor;Laser injury;Lasers;Lesion;LoxP-flanked allele;Macrophage;Measurable;Medical;MEK inhibition;MEKs;melanocyte;Melanocytic Neoplasm;Melanocytic nevus;Melanoma;Melanosis;Melanosomes;Methods;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Natural Immunity;Neoadjuvant Therapy;neoantigens;Neoplasms;Nevus;Oncogenes;Operative Surgical Procedures;Peptides;Phase;PIK3CG gene;pre-clinical;Pre-Clinical Model;prevent;Prevention;promoter;Publishing;recruit;Regimen;Reporting;Reproducibility of Results;Risk;Schedule;senescence;SILV gene;Skin;small molecule;Symptoms;T-Lymphocyte;Tamoxifen;Testing;Therapeutic;Tissues;Titrations;Topical application;Toxic effect;Transplantation;treatment optimization;treatment strategy;tumor;Visual;Xenograft procedure

PROJECT_TITLE: Therapeutic strategies for treatment of giant congenital melanocytic nevi

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research will provide a foundation for understanding how cell fate decisions are controlled within an epithelial stem cell lineage. Epithelial stem cells are central to both normal homeostasis and the progression of diseases such as cancer, so understanding how they are regulated their native, in vivo contexts is important for the development of new diagnostics and therapeutics. The proposed project will also contribute to the NIH mission to foster fundamental creative discoveries by investigating new and poorly understood topics such as stem cell niche competition and the role of pH dynamics in cell fate decisions.

PI_NAMEs: NYSTUL, TODD  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Affect;Aging;Alleles;Area;Atlases;beta catenin;Biological Models;cell behavior;Cell Differentiation process;Cell Lineage;cell type;Cells;Creativeness;daughter cell;Development;Disease;Disease Progression;Drosophila genus;epithelial stem cell;Epithelium;flexibility;Fostering;Foundations;Gene Expression Profile;Genetic;Homeostasis;in vivo;insight;interest;intestinal epithelium;Intestines;Ligands;Link;Malignant Neoplasms;mathematical model;Mission;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Normal tissue morphology;novel;novel diagnostics;novel therapeutics;Ovary;Physiological;Population Dynamics;Positioning Attribute;Post-Translational Protein Processing;Process;Property;Proteins;Protons;quantitative imaging;Research;Resolution;Role;segregation;self-renewal;sensor;Source;stem cell niche;stem cells;Stress;Structure;System;Tissues;tool;United States National Institutes of Health

PROJECT_TITLE: Cell Fate Decisions in Epithelial Stem Cell Lineages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;HIV/AIDS;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Epstein-Barr virus (EBV) bearing diffuse large B-cell lymphomas (DLBCL) are particularly aggressive in immunosuppressed individuals such as those with HIV – highlighting the importance of focusing on EBV- associated factors and pathways. In this application, a new collaboration enables the pursuit of a multi-pronged approach using novel proteolysis targeting chimeras to directly kill DLBCLs latently infected with EBV as well as indirectly kill DLBCL by forcing EBV into the lytic state allowing oncolysis, with the ultimate goal of improving outcomes for those with EBV+ DLBCL.

PI_NAMEs: BHADURI-MCINTOSH, SUMITA  (contact);MCINTOSH, MICHAEL T

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Administrative Supplement;Award;cancer cell;cancer clinical trial;Chemistry;Clinical Trials;Collaborations;college;design;DNA Repair;Epstein-Barr Virus-Related Lymphoma;Florida;Funding;Goals;HDAC3 gene;Histone Deacetylase;HIV;homologous recombination;Human Herpesvirus 4;immunosuppressed;improved outcome;Individual;inhibitor;interest;large cell Diffuse non-Hodgkin's lymphoma;Libraries;Ligands;Lytic;Malignant Neoplasms;Mediating;Medicine;neoplastic cell;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;oncolysis;Oncolytic;Outcome;Pathway interactions;Persons;Pharmacy facility;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Predisposition;Protac;Proteins;recombinational repair;response;targeted agent;therapeutic target;Universities

PROJECT_TITLE: PROTAC-based direct and oncolytic killing of EBV+ DLBCLs through synthetic lethality


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Overall - Project Narrative This project will use a learning healthcare system research framework to (1) develop and validate models for predicting Coordinated Specialty Care disengagement augmented by conversations with participants and clinicians to specify how this knowledge can be integrated with clinical practice and (2) develop and evaluate a centralized referral and intervention navigator service to support participants and families at high risk for disengagement. We will use robust participatory research methods to ensure the integration of CSC program staff, participants, and family members in the development of this service. Five research groups with histories of contributions to FEP/CSC research and clinical practice will collaborate to support these opportunities for in-depth study of disengagement risk and of strategies that can prevent it.

PI_NAMEs: BENNETT, MELANIE E. (contact);CALKINS, MONICA E

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Address;Baltimore;Brain;care providers;Caring;Clinical;clinical care;clinical practice;Clinical Trials;Cognition;cognitive testing;cohort;Collaborations;Communities;Coordinated Specialty Care;cultural competence;Data;Data Analyses;Data Collection;design;Development;early psychosis;Effectiveness;Electronic Mail;Ensure;Evaluation;experience;Family;Family member;first episode psychosis;Fostering;Generations;Goals;Health Services Research;Healthcare;Healthcare Systems;high risk;Hybrids;implementation science;implementation strategy;improved;Infrastructure;International;Intervention;Knowledge;Learning;Length;Lived experience;Maryland;Measurement;medical schools;meetings;Methods;navigator intervention;neuroimaging;Outcome;Participant;peer;Pennsylvania;personalized medicine;Persons;predictive modeling;prevent;Production;Program Research Project Grants;programs;prospective;Provider;Psychopharmacology;Psychoses;Public Health;Recording of previous events;Recovery;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Risk;risk prediction model;Schizophrenia;Services;skills;Specific qualifier value;standard care;systems research;Telephone;Testing;therapy development;Time;Translations;Universities;Visit;Youth

PROJECT_TITLE: Harnessing a Two-State FEP LHS to Optimize Engagement and Prevent Disengagement in CSC

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (06)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Disability Research;Health Services;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: BENNETT, MELANIE E. (contact)

PROJECT_TERMS: Address;Admission activity;Behavioral Research;Biomedical Research;Budgets;career;career development;Clinical;clinical practice;Clinical Research;Clinical Trials;Cognition;cognitive testing;Collaborations;Collection;Communication;Community Practice;Coordinated Specialty Care;Data;Data Analyses;Data Collection;Data Security;data standards;Databases;Development;disability;Disabled Persons;early psychosis;Ensure;Equity;Ethnic Population;Evaluation;Family member;Financial Activity;first episode psychosis;flexibility;Fostering;Generations;Goals;Health Care Research;Health Services Research;Healthcare;Healthcare Activity;Healthcare Systems;high standard;implementation science;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;Intervention;Knowledge;Lead;Leadership;Learning;Lived experience;Maryland;medical schools;member;Monitor;Participant;participant enrollment;Pennsylvania;Persons;prevent;Privacy;Procedures;Process;Production;program dissemination;Program Research Project Grants;programs;prospective;Psychiatry;Psychoses;racial population;Recovery Support;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Risk;risk prediction model;Science;Services;Site;statistics;synergism;Technology;Testing;therapy development;timeline;Training;training opportunity;Underrepresented Populations;Universities;Vision;Work;Youth

PROJECT_TITLE: UMB Admin Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Patient Safety;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

PHR: Clinical Practice Data Research Project - Project Narrative This project will use Connection Learning Healthcare System Core Assessment Battery data to develop and validate longitudinal models for predicting risk of Coordinated Specialty Care disengagement and to integrate stakeholder input on uses in clinical practice. We will develop several versions of a risk calculator predicting length of time in program, program completion, and disengagement and establish longitudinal validity over 2-3 years to compare different calculators’ predictive accuracy. We will leverage the Administrative Core’s community, provider, and lived experience integration strategies and components to develop implementation strategies for using risk information in practice.

PROJECT_TERMS: Address;Admission activity;Affect;Algorithms;Bipolar Disorder;Cardiovascular Diseases;Caring;Classification;Client;Clinical;clinical care;clinical practice;cohort;Communities;Coordinated Specialty Care;Data;Data Collection;Data Set;Dementia;Effectiveness;Ethics;experience;Family member;first episode psychosis;Focus Groups;Fostering;Future;future implementation;Goals;Healthcare Systems;Heel;implementation strategy;Individual;Infrastructure;innovation;Investigation;Learning;Length;Lived experience;Machine Learning;Measures;Medical;Mental Health;Methods;Modeling;Movement;novel;Outcome;Participant;patient engagement;Patients;Perception;Performance;personalized medicine;personalized predictions;Persons;precision medicine;predictive tools;prevent;Program Research Project Grants;programs;Proliferating;prospective;Provider;Psychiatry;Psychoses;random forest;Research;Research Project Grants;Resources;Rest;Risk;Risk Assessment;risk prediction;risk prediction model;Series;Services;Shapes;Site;Specific qualifier value;success;Suggestion;Suicide;Surgical complication;Surveys;Testing;Time;Training;Work

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

PHR: Prospective Practice-Oriented Research Project - Project Narrative This project will develop a hub-based engagement navigator service for participants and families at high risk for disengagement. We will use robust Participatory Research methods to ensure integration of Coordinated Specialty Care (CSC) program staff, participants, and family members in developing all aspects of and materials for the service, conduct feasibility/acceptability testing in three CSC programs, and use this information to guide refinements. This will be followed by a mixed methods hub wide evaluation using a hybrid type I open cohort stepped wedge design to examine feasibility, acceptability, and effectiveness to improve disengagement outcomes and address target mechanisms.

PROJECT_TERMS: acceptability and feasibility;Address;Affect;cohort;community burden;community setting;Competence;Coordinated Specialty Care;Country;Data;Dedications;design;distrust;Early Intervention;early psychosis;Effectiveness;effectiveness research;Enrollment;Ensure;Evaluation;evidence base;experience;Face;Family;Family member;Family Relationship;first episode psychosis;Fostering;Future;Goals;Health system;high risk;Hybrids;implementation barriers;implementation facilitators;Improve Access;improved;Intervention;Interview;intrinsic motivation;Learning;Length;Lived experience;Measures;Mediating;Methods;Modality;Monitor;National Institute of Mental Health;Outcome;Participant;patient engagement;peer support;prevent;Prevention;Procedures;process evaluation;programs;prospective;Randomized, Controlled Trials;Recovery Support;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Science;Services;Social Workers;Specialist;Specific qualifier value;Stress;Structure;System;systems research;Testing;Time;tool;Training;treatment as usual;treatment effect;Vision;Work

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Supplemental Project for NIA R01AG070987 Improvement of Overall recruitment, Latino Community Outreach and MRI acquisition Project Narrative The primary goal of this supplement is to improve Hispanic patient outreach. This will improve patient recruitment, establish good relations to maintain outreach for this and future studies, and it will help underserved Hispanics in Southern Arizona have better vascular care access. We will also improve homogeneity and quality of MRI acquisition.

PI_NAMEs: WEINKAUF, CRAIG C (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Abbreviations;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Arizona;Automobile Driving;Award;Blood Vessels;Budgets;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid stent;Cephalic;Clinic;Clinical;Communities;community clinic;Community Health;Community Outreach;Complex;cost;Data;data acquisition;Dementia;design;Diagnosis;Disease;Enrollment;Ensure;Evaluation;Event;Feedback;Future;Goals;graduate student;Grant;Health Services Accessibility;Hearing;high standard;Hispanic;hispanic community;Hispanic Populations;Image;imaging facilities;improved;Institutional Review Boards;Latino;Latino Population;Low income;Magnetic Resonance Imaging;Materials Testing;Medical;Morphologic artifacts;Motion;Neurocognitive;normal hearing;Not Hispanic or Latino;outreach;Parents;patient outreach;Patient Recruitments;Patients;Phase;Physicians;Policies;prevent;Protocols documentation;Qualifying;Quality Control;recruit;Research;Research Proposals;Science;screening;Secondary to;Spanish;Standardization;Stroke;Students;Study Subject;success;Supervision;Surgeon;System;Testing;Time;Translating;Transportation;Transportation of Patients;Travel;Universities;Vascular Diseases;volunteer;Work

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE  Alzheimer's disease afflicts more than 6 million Americans, costs hundreds of billions of dollars a year, and is  the only major cause of death for which there is no treatment, and mutations in the SORL 1 gene, which codes  for a protein that helps to traffic other proteins to their correct destinations in brain cells, cause endosomal traffic  jams and are a significant factor in the development of both sporadic and familial Alzheimer's disease. This  project has an overall goal to develop the ability to predict which mutations in SORL 1 are pathogenic, and why,  and therefore which patients would benefit from treatments aimed at correcting the traffic jams. Specifically, the  project will contribute to this overall goal by relating pathogenic mutations to their effects on SORL 1 protein  structure, stability and biochemical functions.

PI_NAMEs: PETSKO, GREGORY A (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Amino Acids;Binding;Biochemical;Biological;Biological Assay;Biology;Biophysics;brain cell;causal variant;Cause of Death;Cell Culture Techniques;Cell model;Cellular biology;Code;Complex;Computer software;cost;Cryoelectron Microscopy;Crystallization;Data;data modeling;deep learning algorithm;design;Destinations;Development;Dimerization;Disease;Early Endosome;Endocytosis;Endosomes;falls;familial Alzheimer disease;Genes;Genetic Models;Glutamate Receptor;Goals;Guidelines;Histopathology;Human;human disease;Human Genetics;human model;improved;innovation;insight;Integral Membrane Protein;Late Onset Alzheimer Disease;Lead;Length;Light;Liposomes;Measurement;Measures;Membrane Protein Traffic;Modeling;Molecular Conformation;mouse model;Multiprotein Complexes;mutant;Mutation;Nerve Degeneration;Neurons;novel;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Peptides;Phenocopy;prediction algorithm;predictive modeling;presenilin-1;presenilin-2;Preventive;Property;protective allele;protein folding;protein structure;protein transport;Proteins;receptor;reconstitution;Recycling;Resolution;Risk;structural biology;Structure;Testing;three-dimensional modeling;tool;trafficking;Tubular formation;Ultracentrifugation;Variant;X-Ray Crystallography

PROJECT_TITLE: SORL 1-Retromer Biology in the Pathogenesis of Alzheimers Disease


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Health services researchers have only begun to adopt and apply modern data analytics, a subset of artificial intelligence. Data analytic tools may be particularly useful in understanding and addressing the health care inequities experienced by several AHRQ Priority Populations, especially women, racial and ethnic minorities, and persons in low-income, rural, and urban settings in the U.S. Deep South. The Annual Methods Symposium at the University of Alabama at Birmingham is uniquely positioned as a local, regional, and national outlet to disseminate knowledge of the health services research application of modern data analytic tools to a community of investigators who seek to improve care in the U.S. Deep South and beyond.

PI_NAMEs: GIBSON, MADELINE J (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Annual UAB Methods Symposium

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-T (01)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: IRVINE

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PI_NAMEs: SUN, BRYAN  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TITLE: Insights to Noncoding Disease Variants using Mosaic Diseases


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: OVERALL PROJECT NARRATIVE Bladder cancer is the second most common urologic malignancy; yet, remained a significantly underfunded and understudied cancer type. Major clinical gaps in early bladder lesions [defined as non-muscle invasive bladder cancer (NMIBC)] include 1) lack of mechanistic insights defining NMIBC progression, and 2) lack of platform for risk stratifying NMIBC that recur but never progress, from those that progresses into MIBC and consequently demonstrate poor prognosis. The knowledge gained by our Center will inform future NIMBC management through 1) the development of novel urinary profiling strategies that could risk stratify aggressive NMIBC (Project 1-3); 2) the identification of targets for future precision intervention, either by enhancing/sustaining the tumor- restraining mechanisms (Project 1) and/or inhibiting the tumor-promoting mechanisms (Project 2).

PI_NAMEs: CHAN, KEITH SYSON  (contact);THEODORESCU, DAN

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Address;Affect;anti-cancer research;Antitumor Response;B-Lymphocytes;Basic Science;Benchmarking;Bioinformatics;Biological;Biological Markers;Biology;biomarker development;biomarker validation;Bladder;Breast;Cancer Biology;Cancer Patient;cancer recurrence;cancer type;candidate marker;carcinogenesis;Carcinogens;Cell Communication;cell type;Cells;Clinical;clinical practice;cohort;Coin;Communication;Communities;Data;Development;Diagnosis;Disease;driving force;Ensure;fibroblast-activating factor;Fibroblasts;Fingerprint;functional genomics;Funding;Future;Genes;Genomics;Goals;Human;Immune;Immunoassay;Individual;induced pluripotent stem cell;innovation;insight;Knowledge;knowledge integration;Lesion;Lymphoid Tissue;lymphotoxin beta receptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;Medical center;Modeling;mouse model;Multi-Institutional Clinical Trial;multidisciplinary;Muscle;neoplastic cell;non-muscle invasive bladder cancer;novel;Organ;Outcome;Paracrine Communication;Pathologic;Pattern;personalized intervention;Persons;Pilot Projects;Population;Primary Lesion;progenitor;Prognosis;programs;Property;prospective;Protein Secretion;Proteins;Proteomics;recombinase;recruit;Recurrence;Reporting;Research;Research Personnel;Resource Sharing;restraint;risk stratification;Role;Sampling;Side;single cell technology;single-cell RNA sequencing;success;T-Lymphocyte;tertiary lymphoid organ;transcriptomics;translational oncology;tumor;tumor growth;tumor progression;Tumor Promotion;understudied cancer;urinary;Urine;urologic;Urothelial Cell;Validation;Yin

PROJECT_TITLE: A single-cell spatial map characterizing the stromal TME in bladder and breast early-lesions


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric

ORG_CITY: MORGANTOWN

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: In type 1 diabetes, the heart develops fibrosis and vascular damage that contribute to the heart’s eventual failure. Substance P, a molecule that activates the neurokinin-1 receptor, is reduced in diabetes, predisposing the heart to these adverse changes. The current proposal will explore interactions between substance P, the neurokinin 1 receptor, and adverse changes in the type 1 diabetic heart to assess the potential of activating the neurokinin 1 receptor as a therapy for adverse changes in the type 1 diabetic heart.

PI_NAMEs: CAMPBELL, WILLIAM BRYSON;LEVICK, SCOTT P (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Adolescent and Young Adult;afferent nerve;Amino Acids;Animal Model;Biological;Blood Glucose;Blood Pressure;Blood Vessels;Body Weight;C-terminal;Cardiac;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Count;cell type;Cells;Clinical;Clinical Data;Coronary;Coronary artery;coronary fibrosis;Coronary Vessels;Diabetes Mellitus;Dipeptidyl-Peptidase IV;Disease stratification;effective therapy;EFRAC;Enzymes;Failure;Family;Female;Fibrosis;Freezing;Functional disorder;functional improvement;Future;G-Protein-Coupled Receptors;Goals;Heart;Heart Diseases;Heart failure;heart function;hospitalization rates;Human;Hypertrophy;improved;Individual;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Left Ventricular Remodeling;Left ventricular structure;Ligands;mast cell;Measures;Metabolism;mimetics;Modeling;Monkeys;mouse model;Mus;Myocardial dysfunction;N-terminal;Neprilysin;Nerve;neural;Neurons;Neuropathy;Neuropeptides;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Outcome;Pathogenesis;Patients;Peptide Hydrolases;Peptides;Peptidyl-Dipeptidase A;Phenotype;Plasma;Play;Population;pre-clinical;preservation;prevent;Prevention;primary outcome;Production;receptor;Receptor Activation;Right ventricular structure;Risk;Role;Sampling;secondary outcome;Serum;Severity of illness;SP1 gene;Substance P;substance use;Tachykinin;TACR1 gene;Testing;therapeutic target;Tissues;treatment strategy;type I and type II diabetes;type I diabetic;Vascular remodeling

PROJECT_TITLE: Substance P Metabolites and Receptors in the Pathogenesis of Cardiac Disease in Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-T (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Myoclonic Atonic Epilepsy is a severe neurological disorder that has been linked to loss of function mutations in the SLC6A1 gene. Reduced SLC6A1 expression and function leads to altered signals from inhibitory brain cells and results in developmental abnormalities and epilepsy, yet the role that SLC6A1 plays in the development of inhibitory brain cells and the resultant epilepsy remains unknown. We anticipate that these studies will contribute considerable knowledge to the epilepsy and neurodevelopmental fields, and lead to novel treatment strategies for individuals with severe childhood genetic epilepsies caused by mutations in SLC6A1 and related epilepsy genes.

PI_NAMEs: VARELA, MARIA CARMEN (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Astrocytes;autism spectrum disorder;Behavioral;Biological Assay;Brain;brain cell;Calcium;Cell membrane;Cells;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Cognitive;Communities;comparison control;Complex;Data;Defect;Development;Developmental Delay Disorders;Disease;disease model;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Epileptogenesis;experimental study;Functional disorder;Future;gamma-Aminobutyric Acid;Gene Expression;Genes;Genetic;Growth and Development function;Heterozygote;Human;human induced pluripotent stem cells;human model;Image;Impairment;In Vitro;in vitro Model;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;Intellectual functioning disability;Interneurons;Intervention;Knock-out;Knockout Mice;Knowledge;Link;loss of function;loss of function mutation;Loss of Heterozygosity;Measures;Medial;Mentors;Methods;migration;Migration Assay;Modeling;Morphology;mouse model;multi-electrode arrays;Mus;Mutation;nerve stem cell;Nervous System Disorder;neural network;neurodevelopment;neuron development;neuronal excitability;Neurons;novel;optogenetics;Organoids;patch clamp;patient derived induced pluripotent stem cells;Patients;Phase;Phenotype;Physiological;Play;Postdoctoral Fellow;Presynaptic Terminals;Prevention;Process;Property;protein expression;Quantitative Reverse Transcriptase PCR;Research;Research Personnel;Research Project Grants;Resolution;reuptake;Rodent;Rodent Model;Role;Scientist;Seizures;self organization;Signal Transduction;stem;stem cell model;stem cell proliferation;Synapses;synaptogenesis;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;three-dimensional modeling;timeline;Training;transcription factor;treatment strategy;two photon microscopy;uptake;Variant;voltage;Whole-Cell Recordings;Work

PROJECT_TITLE: Human induced pluripotent stem cell-derived models of SLC6A1-related epileptic encephalopathy

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ORG_CITY: HERSHEY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE: We will convene a national conference focused on dissemination and implementation of knowledge and best practices in human factors science and engineering in healthcare delivery to enhance value, quality, and safety. The human factors approach is essential at this juncture, as sophisticated artificial intelligence (AI) tools are being introduced into healthcare.

PI_NAMEs: BRUNO, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Artificial Intelligence and Human Factors in Healthcare Quality & Safety


ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE People with type 1 diabetes (T1D) have excessive risk for cardiovascular diseases (CVD) even with well-managed traditional cardio-metabolic risk factors. We propose to assess whether chronic autoimmunity could be contributing to the excessive mortality from CVD in T1D by using the blood vessels from the heart and lower limbs that are available from the CaRe-T1D and Medalist bio-repositories. The availability of these tissue libraries will allow in-depth analysis of cardiovascular tissues from T1D to be evaluated using cutting-edge tools such as single cell analysis, spatial transcriptomics, metabolomics and others in order to understand the potential and unusual causes of CVD in T1D due to the presence of autoimmunity.

PI_NAMEs: KING, GEORGE L (contact)

PROJECT_TERMS: Acceleration;adaptive immunity;Advanced Glycosylation End Products;Agatston Score;Age;Amputation;Antigens;Aorta;Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Beta Cell;biobank;Blood Pressure;Blood Vessels;C-Peptide;calcification;Calcium;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Pathology;cardiovascular risk factor;Cardiovascular system;Caring;CD4 Positive T Lymphocytes;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;comparative;congenic;Coronary artery;coronary artery calcium;coronary calcium scoring;cytokine;diabetes management;Diabetes Mellitus;diabetic;Diabetic mouse;Endothelial Cells;Event;Excess Mortality;Exhibits;Genes;glycemic control;Glycosylated hemoglobin A;Heart;heart imaging;High Density Lipoproteins;Hyperglycemia;Hyperlipidemia;Hypertension;I-kappa B Proteins;imaging study;Immune;immune activation;Inbred NOD Mice;Individual;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Insulin-Dependent Diabetes Mellitus;insulitis;Interferon Type II;Interleukin-1 beta;Kidney Diseases;Knowledge;Libraries;Lipids;Lipoproteins;Longitudinal Studies;Low-Density Lipoproteins;Lower Extremity;Macrophage;male;Metabolic Control;metabolomics;Microarray Analysis;mouse model;Mus;Natural Immunity;Necrosis;Non obese;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathologic;Pathology;Pathway interactions;Persons;Plasma;Process;Proinsulin;Proteome;Publishing;Recording of previous events;Regulatory T-Lymphocyte;Reporting;repository;Risk;Risk Factors;risk variant;Sampling;screening;Severities;sex;single cell analysis;single cell sequencing;Smooth Muscle Myocytes;Testing;Time;Tissues;tool;transcriptomics;Vascular Smooth Muscle

PROJECT_TITLE: Characterization of risk factors for excessive cardiovascular diseases (CVD) from circulating and cardiovascular tissues of people with well-controlled chronic type 1 diabetes


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: This Administrative Supplement to Promote Diversity in Health-Related Research will support the career development of Jose Mejia, a post-baccalaureate scholar who will receive a mentored research experience in preparation for applying for admission to nursing school. Under the guidance of Dr. Grant (PI for R01 DK134446: “Pragmatic Clinical Trial of Continuous Glucose Monitoring-based Interventions for Safe Insulin Prescribing in High-Risk Older Patients with Type 2 Diabetes, 02/01/2023 - 01/31/2028), Mr. Mejia will gain research experience by analyzing baseline data related to older Latino participants with type 2 diabetes eligible for the parent clinical trial (approximately 12% of expected participants, similar proportion to the source population in Northern California). The planned projects will supplement the parent R01 by allowing an increased emphasis on examining the similarities and unique differences in how older Latino patients with diabetes engage with the health care system and to current medication-related practices.

PI_NAMEs: GRANT, RICHARD W (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Administrative Supplement;Admission activity;Award;California;career;career development;Caring;Clinical;Clinical Trials;Complex;Continuous Glucose Monitor;Data;design;Diabetes Mellitus;Discipline of Nursing;Eligibility Determination;Enrollment;ethnic difference;experience;Family;Focus Groups;Goals;Grant;Health;health disparity;Healthcare Systems;high risk;Hypoglycemia;improved;insight;Institution;Insulin;interest;Intervention;Interview;Latino;Learning;Lived experience;Mentors;minority investigator;Multivariate Analysis;Non-Insulin-Dependent Diabetes Mellitus;Nursing Schools;older patient;Outcome;Parents;Participant;patient engagement;patient oriented;patient population;Patients;Pharmaceutical Preparations;Population;Postbaccalaureate;Pragmatic clinical trial;Preparation;racial difference;Research;Research Design;Research Personnel;Research Training;Risk;skills;Source;Techniques;Training;Training Activity;Underrepresented Minority

PROJECT_TITLE: Race/ethnic Differences Among Older Patients with Type 2 Diabetes at Risk for Hypoglycemia


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Sterilization testing of the COSMIIC System The aim of this supplement is to conduct sterilization testing of the COSMIIC System components and to make the testing procedures and results available to the public under our open source licenses.

PI_NAMEs: CHESTEK, CYNTHIA ANNE;KILGORE, KEVIN L. (contact);SMITH, BRIAN

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Address;age acceleration;Clinical;clinical application;Collaborations;Data;Devices;Documentation;Equipment and supply inventories;Feasibility Studies;Feedback;Goals;implantable device;insight;Knowledge;Licensing;Life;Materials Testing;Modification;open source;Procedures;Process;Protocols documentation;Research;Research Personnel;Running;Sample Size;Shipping;Sterility;Sterilization;System;Testing;Time;Vendor;web site;Work;Writing

PROJECT_TITLE: Sterilization of the COSMIIC System


PHR: Project Narrative SCS+CARSS to COSMIIC Adapter Lead The goal of this supplement is to create an adapter that can connect between standard spinal cord stimulator electrodes and the COSMIIC System.

PROJECT_TITLE: SCS + CARSS to COSMIIC Adapter Lead


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Relevance to Public Health This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029, and relates to a funded parent award U01-CA254886 focused on genetic changes in solid tumors based on our novel ways for monitoring in live cell changes. Because changes in Tumor Suppressor levels is a well documented risk factor for many cancers, we focus here on their levels and mechanisms of changing them in relation to Chromosome loss – making use of our novel ChReporter methods that provide evidence of physically driven changes to chromosome number. We focus on epigenetic drugs emerging in the clinic and also take gene-specific CRISPR-activation & inhibition approaches to help clarify impacts of chromosome loss on expression levels of key Tumor Suppressors as well as Oncogenes. The work recruits into the NCI and its PSON anew collaboration and newInvestigator, Professor Karmella Haynes.

PI_NAMEs: DISCHER, DENNIS E. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Affect;Cells;chromosome loss;Chromosomes;Clinic;Clinical;Collaborations;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Development;epigenetic drug;Epigenetic Process;epigenetic therapy;Exhibits;Funding;Genes;Genetic;Image;interest;Liquid substance;Malignant Neoplasms;Methods;Modeling;Modernization;Molecular;Monitor;Mutation;novel;Oncogenes;parent project;Pharmaceutical Preparations;Phenotype;professor;programs;PTEN gene;Public Health Applications Research;recruit;Regulation;response;Risk Factors;Solid;Solid Neoplasm;success;TP53 gene;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Stiff, solid microenvironments induce Chromosome loss and challenge Epigenetic therapies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE (RELEVANCE)  This project will construct models of gene regulatory networks controlling early human development by taking an integrative approach involving perturbation of core regulatory network elements, quantitative genomic and proteomic measurements with high temporal and single-cell resolution, and systems level analyses. Knowledge gained from the study will provide a conceptual framework for dissecting gene regulatory networks during cell state transitions, and reveal general features of genomic variants that contribute to cellular and organismal phenotypes.

PI_NAMEs: BEER, MICHAEL A;HADJANTONAKIS, ANNA-KATERINA ;HUANGFU, DANWEI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Adult;algorithmic methodologies;ATAC-seq;Atlases;Attention;Back;Binding Sites;Biological Assay;Biological Models;Cell Fate Control;Cell model;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin Conformation Capture and Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Computing Methodologies;CRISPR interference;CRISPR screen;Data;Data Set;design;Development;Developmental Biology;Disease;DNA Computations;DNA Sequence Analysis;Ectoderm;Elements;Embryo;Embryonic Development;Emerging Technologies;Endoderm;Enhancers;Epiblast;functional genomics;Gene Expression;gene regulatory network;Generations;Genes;Genetic;genetic variant;genome-wide;genomic variation;Genomics;Germ Cells;Germ Layers;Goals;Health;Hi-C;Histones;Homeostasis;Human;Human Development;human embryonic stem cell;improved;Individual;innovation;Knowledge;Learning;Machine Learning;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;mathematical model;Measurement;Mesoderm;Modeling;multimodality;Mus;Natural regeneration;network models;Neuroectoderm;Organoids;Pathologic;Pathway Analysis;Peripheral;Phenotype;Physiological;pluripotency;predictive modeling;Proteins;Proteomics;Publishing;Records;Regulatory Element;Research Personnel;Resolution;Role;screening;self-renewal;Sequence Analysis;Signal Transduction;single cell genomics;single-cell RNA sequencing;Somatic Cell;stem cell biology;stem cell differentiation;System;Systems Biology;temporal measurement;Testing;Tissues;transcription factor;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Genomic control of gene regulatory networks governing early human lineage decisions


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Social Determinants of Health

ORG_CITY: Mission

ORG_NAME: INTERNATIONAL SOCIETY/ EXPOSURE ANALYSIS

ORG_STATE: KS

PHR: Narrative The International Society of Exposure Science (ISES) is the premier international society devoted to bringing the full value of exposure science to research and decision-making to improve human health and the environment. This conference represents the most comprehensive gathering of environmental exposure scientists and environmental health professionals from academia, government, communities and organizations from around the world, reflecting the interdisciplinary nature of the field.

PI_NAMEs: RULE, ANA MARIA (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Academia;Affect;Air;analytical method;Area;Asia;Biological;Canada;citizen science;climate change;Collaborations;Communication;Communities;community based participatory research;community engaged research;Community Participation;Complex;Country;COVID-19;Data;Data Collection;Decision Making;Developing Countries;Development;Discipline;Disparity;Ecosystem;Education;Environment;environmental agent;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Policy;Epidemiology;Europe;Event;exposed human population;Exposure to;extreme weather;Faculty;Financial Support;Food;Fostering;Funding;Goals;Government;Government Agencies;Health;Health Policy;Health Professional;Human;improved;Industry;International;Knowledge;Link;low and middle-income countries;low income country;meetings;member;Mentors;Methodology;Methods;Names;Nature;new technology;next generation;Noise;Nonprofit Organizations;North America;Oral;Participant;pathogen;Peer Review;Policies;Policy Making;posters;Public Health;Radiation;Research;Research Methodology;Research Personnel;Resources;Risk;Scholarship;Science;Scientist;sensor;Societies;Statistical Methods;Students;success;successful intervention;symposium;Technology;tool;Training;Translational Research;Travel;Vulnerable Populations;Water

PROJECT_TITLE: ISES 2024 Annual Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 MGE-D (R3)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Chronic Pain;Pain Research;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Advancements in the treatment and functional restoration of composite bone-muscle traumas are hindered by a lack of available therapies that can repair both of these tissues together. In the parent grant, we proposed to engineer regenerative materials that work in concert with the body’s healing programs and physical rehabilitation to restore the structure-function relationship within and between damaged muscle and bone. The goals of this Research Supplement to Promote Diversity in Health-Related Research are to: 1) to train a highly innovative biomedical engineering graduate student to integrate concepts in biomechanics with regenerative rehabilitation models in musculoskeletal research; 2) determine the impact of load-bearing exercise on muscle/bone regeneration after traumatic injury; 3) evaluate the contribution of exercise intervention timing and intensity on the systemic inflammatory response and functional limb recovery.

PI_NAMEs: NAKAYAMA, KARINA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: allodynia;Animals;Award;Behavioral Model;Biocompatible Materials;Biology;Biomechanics;Biomedical Engineering;bone;Bone Density;Bone Regeneration;career development;Cell Culture Techniques;Characteristics;Clinical;Clinical Treatment;Complex;composite restoration;Cues;cytokine;Data;Development Plans;Educational workshop;Ethics;Exercise;exercise intervention;Exercise Physiology;exercise regimen;experience;Extracellular Matrix;fabrication;Fatigue;Frequencies;functional restoration;Goals;graduate student;healing;Health;health assessment;Histology;Image Analysis;Immune;In Situ;in vivo imaging;Individual;Inflammatory;Injury;innovation;Intervention;Leadership;Length;limb injury;Limb structure;Mentorship;microCT;Mission;Modeling;Mus;Muscle;muscle engineering;Musculoskeletal;musculoskeletal injury;myogenesis;nanoscale;Natural regeneration;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;parent grant;Pattern;peer;Phenotype;Physical Rehabilitation;Physical therapy;Production;programs;Protocols documentation;Recovery;Recovery of Function;regenerative;regenerative approach;Regenerative engineering;regenerative rehabilitation;Regenerative response;Rehabilitation therapy;repaired;Research;research and development;response to injury;Running;Skeletal Muscle;Structure-Activity Relationship;Students;Surgical Management;symposium;systemic inflammatory response;Tactile;Time;tissue regeneration;Tissues;Training;Trauma;Traumatic injury;Weight-Bearing state;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Regenerative engineering for complex extremity trauma


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: RELEVANCE (See instructions): We are examining the role of the myosin molecular motor during aging of healthy and diseased muscles and are attempting to ameliorate muscle degeneration. To this end, we are 1) modeling aging human skeletal muscle by studying myosin with modifications found in human biopsies from aged individuals, 2) over- or under-expressing proteins that are dysregulated in two myosin-based progressive diseases of skeletal muscle and 3) studying mutant cardiac myosins that cause age-related dilated cardiomyopathy.

PI_NAMEs: BERNSTEIN, SANFORD I (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Age;age related;Aging;aging population;aging related;ATP phosphohydrolase;Autophagocytosis;Biochemical;Biological Assay;Biopsy;Cardiac;Cardiac Myosins;Crystallography;Defect;Dilated Cardiomyopathy;Drosophila genus;Drosophila melanogaster;Enhancers;Exhibits;Fiber;Functional disorder;Genetic;Heart;Human;improved;In Vitro;in vivo;Inclusion Bodies;insight;Instruction;Locomotion;Mechanics;Methods;Modeling;Modification;Molecular Biology;Molecular Motors;Motility;Motor;Muscle;muscle degeneration;Muscular Atrophy;mutant;Mutation;Myocardium;Myopathy;Myosin ATPase;myosin storage myopathy;overexpression;Phenotype;Physiology;Progressive Disease;Property;protein aggregation;protein structure;Proteins;proteostasis;Rod;Role;skeletal disorder;Skeletal Muscle;Skeletal Muscle Myosins;Striated Muscles;Structural defect;Structure;Testing;Thick Filament;tool;Transgenic Model;Transgenic Organisms

PROJECT_TITLE: Genetics and Molecular Biology of Striated Muscle Myosin

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The opioid crisis has inflicted a tremendous socioeconomic burden and resulted in the countless loss of lives. In order to further initiatives geared towards resolving the opioid crisis with novel treatments, basic neurophysiological mechanisms that underlie pathological opioid behaviors need to be elucidated. The goal of this proposal is use combinatorial genetic, photometric, electrophysiological, and machine-learning based behavioral analysis to decode the behavioral and neural correlates of the heterogeneous mesolimbic dopamine system that regulate morphine response and associative learning in non-dependent and morphine-dependent mice.

PI_NAMEs: JUAREZ, BARBARA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;Academia;Acute;Advisory Committees;analytical tool;Association Learning;Attenuated;Behavior;Behavioral;behavioral pharmacology;Biomedical Research;Brain region;Calcium;career development;Cells;Cholecystokinin;Chronic;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Computational Technique;conditioned place preference;Corticotropin-Releasing Hormone Receptors;Coupled;CRISPR/Cas technology;Cues;Data Set;Dependence;design;Development;Dissociation;Dopamine;dopamine system;dopaminergic neuron;Dose;Economic Burden;Electrophysiology (science);Equity;experience;Exposure to;Fiber;functional loss;gamma-Aminobutyric Acid;Genes;Genetic;genetic approach;Glutamates;Goals;Heterogeneity;Implant;in vivo;Injections;Interneurons;Laboratories;Learning;Link;Machine Learning;maladaptive behavior;Measures;Medial;Mediating;Mentors;mesolimbic system;Methods;Morphine;Morphine Receptors;Motivation;mu opioid receptors;Mus;Mutagenesis;neural;neural correlate;neuroadaptation;Neurons;neurophysiology;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid use disorder;opioid withdrawal;optical fiber;Pathologic;Pharmaceutical Preparations;Phase;Photometry;Play;Principal Investigator;programs;Psychological reinforcement;Receptor Gene;Receptor Signaling;recruit;Regulation;Relapse;response;reward processing;Rewards;Role;sensor;skills;socioeconomics;Synapses;Technology;Training;Ventral Tegmental Area;Viral;virtual;Virus;Withdrawal;Work

PROJECT_TITLE: Dopamine Circuit Regulation of Morphine Reinforcement Across the Opioid Exposure Cycle


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Genetic Testing;Genetics;Human Genome;Hypertension;Kidney Disease;Mental Health;Pain Research;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative GUARDD-US: People with African ancestry (AAs) have the highest rates of uncontrolled high blood pressure, chronic kidney disease and kidney failure, due in part to APOL1 genetic variants nearly exclusively found in AAs that increase risk of kidney failure up to 10-fold. We will test AA adults with high blood pressure for APOL1 and return the results to patients and their clinicians, to see if early knowledge of high genetic risk improves blood pressure, provider and patient behaviors and is cost effective. ADOPT PGx: Certain genetic variations have been shown to cause poor, intermediate or ultra-rapid of commonly prescribed opioid and SSRI medications, thus genotype guided prescribing like that proposed in this study has the potential to greatly improve treatment and quality of life for patients with pain and depression.

PI_NAMEs: HOROWITZ, CAROL R (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Administrative Supplement;Adult;African ancestry;APOL1 gene;Behavior;Blood Pressure;Chronic Kidney Failure;Clinical Trials;cost;cost effective;Data Analyses;demographics;Genetic Risk;genetic testing;genetic variant;Genetic Variation;Genomic medicine;Genomics;Genotype;Health;Healthcare;Hypertension;implementation research;improved;Kidney Failure;Knowledge;Mental Depression;New York City;Pain;Pain management;patient population;Patients;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Pragmatic clinical trial;prescription opioid;prospective;Provider;Quality of life;Randomized;Risk;Selective Serotonin Reuptake Inhibitor;Testing;timeline;Writing

PROJECT_TITLE: GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Despite the effectiveness of CAR T therapy for patients with refractory B cell malignancies, approximately 50% of patients relapse within one year of treatment. A common cause of relapse is the emergence of CAR-resistant leukemias. Our proposal develops two key models for studying mechanisms of relapse following cellular therapy for leukemia and identifies avenues for improving durability of remission.

PI_NAMEs: ERNST, PATRICIA  (contact);FRY, TERRY J.

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acute Myelocytic Leukemia;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Bar Codes;CAR T cell therapy;CD19 gene;Cell Therapy;Cells;chimeric antigen receptor T cells;Clinical Research;curative treatments;design;Disease remission;Effectiveness;Epigenetic Process;Fusion Oncogene Proteins;Genetic;Heterogeneity;Immunoglobulins;improved;in vivo;leukemia;leukemia treatment;Membrane Proteins;MLL gene;Myelogenous;Patients;Population;Predisposition;pressure;prospective;Refractory;Relapse;relapse patients;Resistance;stem cells;Study models;System;Translocation Breakpoint;tumor

PROJECT_TITLE: Defining and predicting features of lineage-switch potential in KMT2A-r B-ALL using barcoding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Natural vocal communication relies on the perception and production of signals influenced by internal states and environmental conditions. The proposed project aims to unify our neurobiological understanding of context-dependent auditory perception and vocal production in songbirds by integrating both behaviors into a common analytical framework. This proposal outlines a novel approach to understanding how networks of neurons can affect different behavioral goals, offering insight into how neural population dynamics shape complex, flexible behaviors through conserved mechanisms.

PI_NAMEs: GORMAN, JULIA C (contact)

PROJECT_TERMS: Acoustics;Active Listening;Affect;Animals;Area;Auditory;Auditory area;Auditory Perception;auditory processing;Behavior;Behavioral;Biological Models;bird song;Birds;Brain;brain control;career;Categories;Chronic;Communication;communication behavior;Complex;Cues;Data;Data Analyses;data modeling;Decision Making;design;Development;Dimensions;dynamic system;Electrophysiology (science);Encapsulated;Environment;European;experience;experimental study;flexibility;Gestures;Goals;high dimensionality;innovation;insight;Instinct;Laboratories;Learning;Link;markov model;Measurable;Measures;Methods;Modeling;Motivation;Motor;Motor Cortex;Movement;neural;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;Neurophysiology - biologic function;Neurosciences;neurotransmission;novel;novel strategies;Pattern;Perception;Phase;Population;Population Dynamics;post-doctoral training;Postdoctoral Fellow;Probability;Production;Property;Recurrence;Research;Research Personnel;response;Sensory;sensory system;Shapes;Signal Transduction;skills;Songbirds;Space Models;Structure;Sturnus vulgaris;Systems Theory;Techniques;Testing;Training;Work

PROJECT_TITLE: Neural population dynamics underlying flexibility in natural communication behaviors


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Obesity;Pediatric

PHR: Narrative Cardiovascular disease is the leading cause of death in people with type 1 diabetes, but its causes are poorly understood in this vulnerable population. This project seeks to uncover the molecular mechanisms by which dysfunction in epicardial adipose tissue cascades onto coronary arteries to cause cardiac disease in people with type 1 diabetes.

PI_NAMEs: GUPTA, RAJAT M;MAJITHIA, AMIT  (contact)

PROJECT_TERMS: Address;Adhesions;Adipocytes;adipokines;Adipose tissue;analytical method;angiogenesis;ATAC-seq;Atlases;Automobile Driving;Big Data;biobank;Biological Assay;Blood Vessels;Cardiac;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Catalogs;causal variant;Cause of Death;Cell Physiology;cell type;Cells;combinatorial;comparative;Complex;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary vasculature;Credentialing;Data;Development;Diabetes Mellitus;differential expression;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;epigenomics;Etiology;Event;Fatty acid glycerol esters;Freezing;Functional disorder;functional genomics;Future;Genes;Genetic;genomic data;Genomics;Heart Diseases;Human;human tissue;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Measurement;Mendelian randomization;Methods;migration;Molecular;monocyte;mortality;multiple omics;Mutation;Myocardium;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Nuclear RNA;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;preservation;Prevention;programs;Proteomics;Research;Research Personnel;Resolution;response;RNA;Running;Sampling;System;Technology;Testing;Thick;Tissue Banks;Tissue Sample;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Vulnerable Populations

PROJECT_TITLE: Single-cell, multi-omic investigation of epicardial adipose and coronary endothelial dysfunction in type 1 diabetes


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Despite the critical influence of both aging and the immune system on carcinogenesis there is little understanding of the interplay between aging and anti-cancer immune responses. We will use quantitative in vivo genetic approaches to generate tumors with alteration in diverse immune regulators and assess how age impacts the influence of the adaptive and innate immune systems on lung carcinogenesis.

PI_NAMEs: RETICKER-FLYNN, NATHAN EDWARD;WINSLOW, MONTE MEIER (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Age;age effect;age related changes;aged;Aging;analytical method;anti-cancer;Bar Codes;Biological Response Modifiers;Cancer Model;cancer therapy;carcinogenesis;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Environment;experimental study;gene function;Genes;genetic analysis;genetic approach;Genetically Engineered Mouse;Genome engineering;Genotype;Immune;Immune response;Immune system;in vivo;in vivo Model;Innate Immune Response;Innate Immune System;insight;interest;Laboratories;lung cancer cell;lung cancer prevention;lung carcinogenesis;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Pathway interactions;Resolution;response;Statistical Methods;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor initiation

PROJECT_TITLE: Genetic analysis of aging on immune responses to lung cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Per SPA document not needed

PI_NAMEs: FREDERICK, KENDRA KING (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TITLE: High sensitivity NMR for structure determination of neurodegenerative disease associated protein aggregates in native contexts


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Psychosis;Rural Health;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PI_NAMEs: WOODBERRY, KRISTEN ANNE (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: acute care;Address;Adolescent;Adolescent and Young Adult;Age;aged;Agreement;attenuated psychosis syndrome;automated analysis;Caring;Centers of Research Excellence;Clinical;Collaborations;Communities;Data;design;Development;Diagnosis;Early Intervention;Electronic Health Record;Equipment;Evidence based intervention;fifth grade;Goals;high risk;improved;improved outcome;Individual;Interview;Life;Maine;Measurement;Measures;Medical Records;Mental Health;Mental Health Services;Minority;Modeling;Outcome;Patient Self-Report;Performance;Primary Care;primary care patient;primary care practice;primary care setting;Protocols documentation;Psychometrics;Psychoses;psychotic;Psychotic Disorders;rapid detection;Reading;recruit;Research;Rural;Rural Community;rural disparities;Sampling;Schizophrenia;screening;Screening procedure;sociodemographics;Speech;Standardization;Structure;Symptoms;Testing;Time;tool;Triage;Validity and Reliability;Writing;young adult;Youth

PROJECT_TITLE: Developing Universal Psychosis Screens for Use With Maine Youth in Primary Care


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: TEMPLE, JEFF R (contact)

PROJECT_TITLE: CE23-005 - Longitudinal mixed-methods study of Firearms among Ethnically Diverse Adolescents and Young Adults


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

PHR: PROJECT NARRATIVE Staphylococcus sp. are essential members of the human skin microbiome. We seek to understand the mechanisms by which genetically diverse staphylococci isolated from human skin contribute to skin health and homeostasis.

PI_NAMEs: OH, JULIA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;Affect;Atopic Dermatitis;Cell Separation;cell type;Collection;commensal microbes;Congenital ichthyosis;congenital immunodeficiency;CRISPR interference;Data;Disease;Eczema;experimental study;Fibroblasts;Genetic Transcription;Genus staphylococcus;Goals;Health;Homeostasis;Human;Immune system;Immunity;immunoregulation;Inflammatory;inflammatory milieu;intercellular communication;interest;Mediating;member;metabolomics;microbial;microbiome;Modeling;Molecular;Mucous Membrane;pathobiont;Patients;Proteomics;response;Role;Signal Pathway;single-cell RNA sequencing;Skin;skin barrier;skin disorder;skin microbiome;Staphylococcus aureus;Staphylococcus epidermidis;Staphylococcus haemolyticus;Staphylococcus hominis;Surveys;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Molecular mechanisms of staphylococcal modulation of skin homeostasis


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Program Director/Principal Investigator (Last, First, Middle): Bekker, Linda-Gail The University of Cape Town Clinical Trials Unit (UCTCTU) based at the Desmond Tutu HIV Centre, University of Cape Town has four unique, expert and integrated clinical research sites which are ready and willing to contribute to the research priorities of the 4 NIH funded clinical trial Networks namely the ACTG, IMPAACT, HPTN and HVTN. Collaboratively this clinical trials consortium will utilise the experience and expertise of the core and it’s sites to efficiently and effectively promote the research and development of new innovations in treatment, prevention and management of HIV, tuberculosis and related conditions.

PI_NAMEs: BEKKER, LINDA-GAIL GAIL (contact)

PROGRAM_OFFICER_NAME: GREENFIELD, TERI L

PROJECT_TERMS: Africa;Africa South of the Sahara;AIDS clinical trial group;clinical diagnostics;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Communities;Competence;Country;Disease;epidemic response;experience;Face;Faculty;Funding;Goals;Health Sciences;HIV;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;Infrastructure;innovation;Institution;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratories;Leadership;Location;Methods;Persons;Population;Prevention;Principal Investigator;programs;Reporting;Research;research and development;Research Priority;Resources;Site;South Africa;Southern Africa;synergism;Tuberculosis;United States National Institutes of Health;Universities

PROJECT_TITLE: HIV/AIDS Clinical Trials Units University of Cape Town CTU 2020 to 2027


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Skin Cancer

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Emerging data from our parent grant support the novel concept that age-related detrimental changes in the dermal compartment drive skin cancer initiation. The aged dermis drives cancer initiation, in part, by influencing the functions of skin immune cells. This supplemental proposal seeks to use the most advanced high-definition spatial gene expression tools to extend the findings of the parent grant by examining the interactions of immune cells with the aged dermis during cancer initiation.

PI_NAMEs: DLUGOSZ, ANDRZEJ A.;FISHER, GARY J (contact);QUAN, TAIHAO

PROJECT_TERMS: Acceleration;Accounting;Age;age effect;age related;age related changes;aged;Aging;aging related disease;American;Biology;Cancer Center;cancer initiation;Carcinoma;Cell Communication;Cells;Cutaneous;Data;data acquisition;Data Analyses;data management;Dermal;Dermis;Development;driver mutation;Elderly;Epidermis;Extracellular Matrix;Fibroblasts;Financial Hardship;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Modified;Healthcare Systems;Human;humanized mouse;Immune;immune cell infiltrate;Immune response;Immunity;immunoregulation;In Situ;Individual;Infiltration;Inflammation Mediators;insight;interest;Investigation;keratinocyte;Keratinocyte cancer;Location;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;medical schools;Michigan;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;neoplastic cell;notch protein;novel;Older Population;Oncogenic;parent grant;Pathology;Personnel Management;Phenotype;Physiological;premalignant;Production;professor;programs;Proteins;Quality Control;recruit;Research;Resolution;Resource Sharing;response;Sentinel;Skin;Skin Cancer;Skin Carcinogenesis;Source;Squamous cell carcinoma;Squamous Cell Neoplasms;Technology;Testing;tool;TP53 gene;transcriptome;Transgenes;tumor immunology;tumor initiation;Tumor stage;tumorigenesis;tumorigenic;Universities;Urology;virtual

PROJECT_TITLE: The impact of aged-related dermal microenvironment on the development of precancerous stroma and cancer initiation


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The MetNet Center for Systems-level Study of Metastasis will elucidate how dynamic interactions between neuronal cells, localized lymphatics, metabolites and cancer cells collectively contribute to the emergence of metastatic disease—thereby identifying critical genes as therapeutic targets for its eradication.

PI_NAMEs: TAVAZOIE, SOHAIL F. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: analytical method;Automobile Driving;Bioinformatics;Biological;biological systems;Biology;Breast Cancer Cell;cancer cell;cancer therapy;Cell Communication;Cell Physiology;cell type;Cells;chemotherapy;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colorectal Cancer;colorectal cancer metastasis;Colorectal Neoplasms;Complex;Computer Analysis;Computing Methodologies;Development;Disease;Dissection;Endothelial Cells;Epidemiology;Event;experience;Extracellular Matrix;Gene Expression;Generations;Genes;Genetic;Goals;Grant;Image;Immune;Immunity;innovation;insight;Knowledge;Lymphatic;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Metabolic;Metabolite Interaction;Methods;Molecular;multidisciplinary;Neoplasm Metastasis;nerve supply;Nervous System;neural;Neuroepithelial;Neuroimmune;Neurons;neurotransmission;novel;Nutrient;Phase;Phenotype;Physicians;Positioning Attribute;prevent;Primary Neoplasm;Process;programs;Property;Research Personnel;response;RNA-Binding Proteins;Role;Scientist;Series;Shapes;Signal Transduction;Signaling Protein;single cell sequencing;Site;success;System;Systems Biology;Technical Expertise;Technology;therapeutic target;tool;transcription factor;treatment response;tumor;tumor immunology;tumor metabolism;tumor progression

PROJECT_TITLE: Mechano-metabolism of Cancer Cells: The Role of Extracellular Matrix Stiffness


PHR: The Center for Tumor-Immune Systems Biology at MSKCC NARRATIVE Cancer immunotherapies are designed to harness the human immune system to attack cancer cells and eliminate tumors. Breakthroughs in cancer immunotherapy such as checkpoint blockade agents have revolutionized cancer care, but only a fraction of patients with specific tumor types respond to these new treatments. Our proposed Research Center will deploy tools from systems biology to improve our fundamental understanding of tumor-immune interactions in contexts where current immunotherapies fail and to develop novel strategies for enhancing responses in contexts where they have only partial success.

PI_NAMEs: LESLIE, CHRISTINA S (contact);TANSEY, WESLEY

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Algorithmic Analysis;anti-cancer;Anti-Inflammatory Agents;Astrocytes;Award;Blood Vessels;Brain;Cancer Biology;cancer care;cancer cell;Cancer Center;cancer immunotherapeutics;cancer immunotherapy;Caspase;CD8-Positive T-Lymphocytes;Cell Death;Cells;Chromatin;Clear cell renal cell carcinoma;clinical care;Colon Carcinoma;Colorectal Cancer;Complex;Computational Biology;computer studies;Computing Methodologies;Data;Data Set;Dendritic Cells;design;Development;Disease associated microglia;Distal;Ecosystem;Education and Outreach;Educational workshop;Engineering;Epithelioid Sarcomas;experimental study;Functional disorder;Genes;Genetic Transcription;graduate student;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunofluorescence Immunologic;immunogenic;immunogenic cell death;Immunological Models;Immunologics;Immunology;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;innovation;insight;Invaded;Investigation;learning strategy;lectures;Ligands;Link;Liver;Lung Adenocarcinoma;machine learning model;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma Cell;Memorial Sloan-Kettering Cancer Center;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Leptomeninges;Methods;Mismatch Repair;Mitochondria;Modality;Modeling;Molecular Analysis;mouse model;multidisciplinary;Multiomic Data;multiple omics;novel;novel strategies;optical imaging;Organ;Patients;Process;programs;receptor;Refractory;refractory cancer;Renal Cell Carcinoma;Research;Research Personnel;Research Project Grants;Resistance;Resource Sharing;response;Role;Scientific Advances and Accomplishments;Scientist;SMARCB1 gene;Solid Neoplasm;standard of care;success;symposium;System;Systems Biology;T cell response;T memory cell;T-Lymphocyte;Technology;Therapeutic;tissue regeneration;tool;Training;Training Activity;Training Programs;transcriptomics;tumor;Tumor Immunity;tumor immunology;tumor-immune system interactions;undergraduate student

PROJECT_TITLE: Spatial characterization of the tumor-immune microenvironment in SMARCB1-deficient epithelioid sarcomas


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PARKTOWN

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: PROJECT NARRATIVE HIV and TB constitute major threats to human health. Progress in understanding and managing HIV has been revolutionary and rapidly translated into practice. For epidemic control, we still require an effective HIV vaccine, biomedical interventions to solve adherence issues in treatment and prevention, and a cure. Similarly, an effective TB vaccine must still be found.

PI_NAMEs: GRAY, GLENDA E (contact);MOHAPI, LERATO ;PANCHIA, RAVINDRE

PROGRAM_OFFICER_NAME: ROBY, GREGG A,

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;Age;Anti-Retroviral Agents;Child;Clinical Research;clinical research site;Clinical Trials Network;Clinical Trials Unit;Clinics and Hospitals;Communities;Development;Disease remission;Epidemic;epidemic response;Ethics;Ethnic Origin;Generations;Geography;Goals;Health;HIV;HIV vaccine;HIV/AIDS;HIV/TB;Human;Human Milk;Incidence;Infant;Infection;International;Intervention;Investments;Joints;Monoclonal Antibodies;novel;Oral;pediatric human immunodeficiency virus;Persons;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevent;Prevention;programs;racial diversity;Research;Research Support;Role;Scientist;side effect;South Africa;South African;success;Technology;Therapeutic;Time;Translating;transmission process;treatment as prevention;Tuberculosis Vaccines;United Nations;United States National Institutes of Health;vaccination strategy;vaccine immunogenicity;Woman

PROJECT_TITLE: PHRU-Setshaba Clinical Trials Unit


PROJECT_TERMS: analytical method;Automobile Driving;Bioinformatics;Biological;biological systems;Biology;Breast Cancer Cell;cancer cell;Cancer Model;cancer therapy;Cell Communication;Cell Physiology;cell type;Cells;chemotherapy;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colorectal Cancer;colorectal cancer metastasis;Colorectal Neoplasms;Complex;Computer Analysis;Computing Methodologies;Development;Disease;Dissection;Endothelial Cells;Epidemiology;Event;experience;Gene Expression;Generations;Genes;Genetic;Goals;Grant;Image;Immune;Immunity;innovation;insight;Knowledge;Lymphatic;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Metabolic;Metabolite Interaction;Methods;Molecular;multidisciplinary;Neoplasm Metastasis;nerve supply;Nervous System;neural;Neuroepithelial;Neuroimmune;Neurons;neurotransmission;novel;Nutrient;Phase;Phenotype;Physicians;Positioning Attribute;prevent;Primary Neoplasm;Process;programs;Property;Research Personnel;response;RNA-Binding Proteins;Role;Scientist;Series;Shapes;Signal Transduction;Signaling Protein;single cell sequencing;Site;success;System;Systems Biology;Technical Expertise;Technology;therapeutic target;tool;transcription factor;treatment response;tumor;tumor immunology;tumor metabolism;tumor progression

PROJECT_TITLE: Dissecting the co-evolution of tumor and tumor-associated immune niches using orthotopic colorectal cancer models


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Deficits in learning and memory are pathological hallmarks of a range of cognitive disorders. Using a high- throughput learning paradigm in genetic outbred mice, we found gene expression differences in the subicular complex and will determine how genetic variation influences neuronal cell-type properties and functions that affect goal-directed learning. This will reveal how learning ability and deficits can manifest across individuals with diverse genetic backgrounds.

PI_NAMEs: CAREY, ALANNA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Adolescence;Affect;anatomical tracing;Appointment;Attention;autism spectrum disorder;Behavior;Behavioral;Brain;Brain region;Calcium;Candidate Disease Gene;candidate identification;career;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition Disorders;Cognitive;cognitive ability;Complex;Decision Making;Diagnosis;Disease;Doctor of Philosophy;Educational process of instructing;Emotions;Environment;Exhibits;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Family;Genes;Genetic;Genetic Screening;Genetic Variation;Goals;Grant;Health;Heritability;Hippocampus;Home;Human;Image;improved;in vivo;Inbred Strain;Inbred Strains Mice;Inbreeding;Individual;Individual Differences;Intellectual functioning disability;Intrinsic factor;Knowledge;Learning;learning ability;Learning Disabilities;Learning Disorders;Link;Mediating;Memory;memory retrieval;Mentors;Methods;Microscope;Molecular;Morphology;Motivation;Mouse Strains;multiple omics;Mus;Nervous System;neural;neural circuit;Neurobiology;neurogenetics;Neurons;Output;Pathologic;Pattern;Perception;Personal Satisfaction;Photons;Population;Postdoctoral Fellow;postnatal development;Principal Investigator;Process;Property;Quantitative Trait Loci;Research;Research Project Grants;Rewards;Risk Factors;Role;Scientist;Shapes;skill acquisition;skills;Source;Stress;success;System;Techniques;Testing;Tissue-Specific Gene Expression;Training;trait;transcriptomics;Variant;way finding;Writing

PROJECT_TITLE: Genetic and Neural Sources of Individual Differences in Goal-directed Learning in Health and Disease