NIH_SPENDING_CATS: Biotechnology;Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: OMAHA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Traumatic injury is the leading cause of death from ages 1-44 in the United States, claiming more than 200,000 lives per year and is responsible for millions of hospital encounters at an annual cost of over $4 trillion USD. While approximately half of trauma patient deaths occur early after injury from bleeding or brain injury, the other half occur in a delayed fashion and frequently are related to organ failure (lungs, kidneys) that is driven, in part, by inflammatory responses. We are performing research focused on understanding how a key inflammatory system called complement gets activated and contributes to the organ failure and delayed deaths observed after traumatic injury, which may eventually lead to novel therapeutic interventions to prevent death in these predominantly young, healthy patients who would otherwise have a long life ahead of them.

PI_NAMEs: BARRETT, CHRISTOPHER DAVID (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Acute;Age;Alteplase;Animals;Antibodies;Antigens;Award;Binding;Biological Assay;Biological Markers;Blood Circulation;Blood Coagulation Disorders;Brain Injuries;Bypass;career;Cause of Death;Cell Culture Techniques;Cessation of life;Circulation;Clinical;Clinical Research;Coagulation Process;Complement;Complement Activation;complement pathway;complement system;cost;Coupled;Data;Development;Dryness;Endothelial Cells;Endothelium;Experimental Designs;exposed human population;Fibrinolysis;fighting;Foundations;Future;Generations;Glycobiology;Glycocalyx;Goals;hemodynamics;Hemorrhage;Hemorrhagic Shock;Hospitals;Human;hypoperfusion;Immune system;Immunohistochemistry;improved;improved outcome;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Investigation;Ischemia;Kidney;Knockout Mice;Knowledge;Lectin;Life;Link;Literature;Lung;lung injury;Mannose Binding Lectin;Mass Spectrum Analysis;Measurement;Mediating;Medicine;Mentors;Mentorship;Methodology;microbial;model design;Modeling;Molecular;mortality;mouse model;Multiple Trauma;Mus;novel therapeutic intervention;Organ failure;organ injury;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Plasma;Plasmin;Polysaccharides;prevent;Process;programs;Proteins;randomized, clinical trials;Research;response;response to injury;Role;Sampling;Scientist;Series;severe injury;Shock;Signal Pathway;skill acquisition;skills;Specificity;Stimulus;Surgeon;System;Testing;Therapeutic;therapeutic target;Trauma;trauma induced coagulopathy;Trauma patient;Traumatic injury;Traumatic Shock;United States;Vascular Endothelium;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of Complement Activation in Traumatic Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Telehealth

ORG_CITY: CORONA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SANO HEALTHCARE CONSULTANTS, LLC

ORG_STATE: CA

PHR: Methadone, the most dispensed Medications for Opioid Use Disorder (MOUD) in poor and minority neighborhoods, which maintains the most stringent federal regulations, must be obtained at an Opioid Treatment Program (OTP), for one, two, or three years of daily supervised use before a person receives up to 6, 14, and 30 days of unsupervised take-home doses, respectively. Future health innovations must deliver low-cost liquid methadone dispensing and telehealth solutions through a single device to overcome current digital barriers (e.g., required use of a mobile phone/smartphone) and traditional SUD barriers (e.g., taking time off work, long travel times, transportation costs, pharmacy preparation costs). SANO’s MOUD-Environmental Interactive Device (EID) provides such a single device solution, with capabilities of obtaining Food and Drug administration Breakthrough Medical Device Designation, as it is comprised of (a) an inner-container, which uses electromechanical valves to precisely dispense up to 30-days liquid methadone through a low-cost volumetric-control system; (b) a reusable external Smart- container with audio, video, and a low-cost gravimetric-control system (supplemental adherence/device efficacy assessment); (c) Wi-Fi and Bluetooth® capability for remote supervised use (Video Observed Therapy) and telehealth/behavioral health access, without use of a smartphone; and (d) a unique device identification system with biometric security (Phase 2).

PI_NAMEs: KENDRICK, EDWIN  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Adherence;Air;Altitude;barometric pressure;barrier to care;behavioral health;Biometry;Bluetooth;Calibration;Caring;Cells;Cellular Phone;cost;Cost Control;density;design;Devices;digital;Dose;Early Diagnosis;Economic Burden;economic impact;efficacy evaluation;Environment;fabrication;Future;Geography;Grain;Health;Home;Hour;Humidity;improved outcome;innovation;Intervention;Liquid substance;Medical Device;medication for opioid use disorder;meetings;Methadone;Methods;Minority;Modeling;mortality;Neighborhoods;novel;Opioid;opioid overdose;opioid treatment program;opioid use disorder;Overdose;Pathway interactions;person centered;Persons;Pharmaceutical Preparations;Pharmacy facility;Phase;point of care;Preparation;prevent;Privacy;prototype;Quality Control;Regulation;remote assessment;remote technology;Residual volume;Security;severe mental illness;Solid;Substance Use Disorder;Surface;System;telehealth;Temperature;Testing;Time;Transportation;Travel;United States Food and Drug Administration;Video Recording;wireless fidelity;Work

PROJECT_TITLE: Advancing Access to Opiate Care and Treatment through a Novel Liquid Methadone Dispensing Device and SMART Container

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-S (M1)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This assesses whether integrated Dually Eligible Special Needs Plans (D-SNPs) in Medicare offer adults living with Alzheimer’s disease and Alzheimer’s related dementias (AD/ADRD) improved long-term care coordination and better outcomes compared with non-integrated D-SNPs. The results of this project will be used to inform state Medicaid policy decisions regarding D-SNP implementation in their states and also will help individuals with AD/ADRD and their families select a Medicare Advantage health plan that best meets their individualized needs.

PI_NAMEs: SLADE, ERIC  (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Abnormal coordination;Acute;Address;Admission activity;Adopted;Adult;Advocate;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Beds;Behavioral;beneficiary;care coordination;care providers;care systems;Caring;Case Management;Categories;Chronic;Chronic Care;Communication;Communities;community based service;comparative effectiveness study;compare effectiveness;Complex;Comprehensive Health Care;cost;Data;Data Set;Dementia;dementia care;deprivation;Diagnosis;Disadvantaged;Disparity population;Drug Prescriptions;dual eligible;Dual Enrollment;Enrollment;evidence base;Exclusion;exhaust;Family;financial incentive;follow-up;Goals;Grant;Health;health care availability;Health Insurance;health plan;Health Policy;Home;Home Health Aides;hospital readmission;Hospitals;improved;Incentives;indexing;Individual;Inequity;Insurance Carriers;insurance plan;Letters;Link;Long-Term Care;Managed Care;Managed Care Programs;Medicaid;Medicaid eligibility;Medicaid services;Medical;Medicare;Medicare/Medicaid;Modeling;mortality risk;Nursing Homes;older adult;Older Population;Outcome;Outcome Study;Persons;Persuasive Communication;Policies;Privatization;Process;programs;Provider;Public Health;Qualifying;Quality Indicator;Quality of Care;readmission risk;Research;Resources;safety net;Self Care;Services;Social support;socioeconomic disadvantage;Source;Special needs plan;Structural Models;System;telehealth;trend;United States Centers for Medicare and Medicaid Services;Visit

PROJECT_TITLE: Health Care Access, Quality, and Outcomes among Individuals with Dementia in Dual Eligible Special Needs Plans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Glaucoma is a progressive neurodegenerative disorder of the optic nerve and retinal ganglion cells (RGCs) which affects a substantial percentage of the adult and elderly population of the United States. Clinical studies and our preliminary experimental data in mice suggest that there is an understudied relationship among serotonin, an important neurotransmitter, RGC function, and glaucoma. In this proposal, we will study the roles that serotonin level and a key serotonin receptor play in RGC biology in both normal mice and mice with experimental glaucoma.

PI_NAMEs: FRANKFORT, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Adrenergic beta-Antagonists;Adult;Affect;Agonist;Amacrine Cells;Anatomy;antagonist;Axon;Axonal Transport;Behavioral;biobank;Biology;Blindness;brain cell;brain circuitry;Cell Density;Cell Physiology;Cell Separation;Cell Survival;cell type;Cells;Cellular biology;Clinical;Clinical Research;Complex;conditional knockout;Data;Data Set;Disease;DLG4 gene;Dose;drinking water;Elderly;Electroretinography;Excitatory Synapse;Fibronectins;ganglion cell;Ganglion Cell Layer;gephyrin;Germ Lines;Glaucoma;Histology;Human;Immunohistochemistry;In Situ Hybridization;in vivo evaluation;Inhibitory Synapse;Injury;Inner Plexiform Layer;Intrabody;intravitreal injection;Investigation;Knock-out;Knowledge;Label;Light Cell;loss of function;macula;Maps;Measures;Mediating;Membrane;Membrane Potentials;Messenger RNA;Microspheres;Modeling;multi-electrode arrays;Mus;mutant;Neurites;Neurodegenerative Disorders;neuroprotection;neuroregulation;Neurotransmitters;novel;Open-Angle Glaucoma;Operative Surgical Procedures;optic nerve disorder;Oral;overexpression;Participant;patch clamp;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiologic Intraocular Pressure;Physiological;Physiology;Play;Population;postsynaptic;Potassium Channel;Predisposition;prevent;Primary Open Angle Glaucoma;Progressive Disease;protective effect;Proteins;receptor;Regulation;Resistance;response;Retina;retinal damage;Retinal Ganglion Cells;retinal nerve fiber layer;reuptake;Risk Factors;Role;Selective Serotonin Reuptake Inhibitor;Series;Serotonin;serotonin receptor;Signal Transduction;single-cell RNA sequencing;Site;Subcellular Anatomy;superior colliculus Corpora quadrigemina;Synapses;System;Techniques;Testing;Thick;Tissues;Transcript;transcriptomics;United States;Vision;Visual

PROJECT_TITLE: Mechanisms of serotonin and serotonin receptor biology in normal and glaucomatous retinas

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative: Wolbachia bacteria of arthropods are key to several global initiatives such as the World Mosquito Program in controlling pests and the transmission of arboviruses such as dengue. Based on new data demonstrating Wolbachia’s ability to inhibit fungal pathogenesis as well, this proposal will combine a variety of approaches to determine the breadth, mechanistic basis, and translational potential of this phenotype. Doing so will have many important implications for human health, including the potential for novel antifungal therapies, bolstering the accuracy of population modeling for vector control initiatives, and increasing our basic understanding of interkingdom microbial interactions within hosts.

PI_NAMEs: PERLMUTTER, JESSAMYN  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Advisory Committees;Aedes;Affect;Antarctica;anti-fungal agents;Antifungal Therapy;arboviral disease;Arboviruses;Area;arthropod-borne;Arthropods;Attention;Bacteria;Basic Science;Bioinformatics;Biological Assay;Biology;burden of illness;career;Committee Members;control trial;Culicidae;Cytoplasm;Data;Data Set;Dengue;Dengue Virus;Diet;disease transmission;Drosophila genus;Drosophila melanogaster;endosymbiont;Exhibits;experimental study;feeding;fighting;fitness;fly;Frequencies;fungus;Future;Gene Expression;Generations;Genes;Genetic;Genetic Models;Genetic study;Genotype;Goals;Health;Human;human disease;Immune;Immune response;Immunity;improved;Individual;Infection;Inherited;insight;interest;Kansas;Knowledge;Life;Measures;Mediating;Medical;metabolomics;Microbe;microbial;microorganism interaction;Modeling;Molds;Molecular;Mothers;Mycoses;Nematoda;novel;Nutrient;Nutrient availability;Nutritional;offspring;Organism;Outcome;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Pest Control;Phenotype;Play;Population;predictive modeling;Prevalence;programs;Reproduction;Research;Research Personnel;Resources;Role;success;symbiont;System;Systemic infection;Techniques;Testing;Therapeutic;Time;Training;transcriptome sequencing;transcriptomics;translational potential;transmission process;Universities;vector control;Viral;viral transmission;Wolbachia;Yeasts;ZIKA;Zika Virus

PROJECT_TITLE: Breadth and mechanism of Wolbachia-based inhibition of fungal infection in Drosophila

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Child obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are driven by the early onset and progression of insulin resistance, fueled by diets high in sugars. Over 7 million children in the United States are estimated to be affected by MASLD and the accompanying features of the cardiometabolic syndrome including abdominal obesity, insulin resistance, and dyslipidemia. The aims of this K24 will expand the mentorship of new patient-oriented researchers and increase patient-oriented research in the area of prevention of childhood cardiometabolic disease.

PI_NAMEs: VOS, MIRIAM B. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adult;Affect;Alanine Transaminase;Ancillary Study;Area;Award;Biological Markers;Body Composition;Cardiometabolic Disease;cardiometabolism;cardiovascular risk factor;career;career development;Career Mobility;Central obesity;Chemosensitization;Child;Childhood;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;Complex;Data;design;Diet;dietary;Dietary Sugars;Dyslipidemias;early onset;early-career faculty;Educational workshop;Enrollment;Environment;evidence base;experience;Extramural Activities;Faculty;Fatty Liver;Fructose;Funding;Genes;Genetic;Genetic Predisposition to Disease;Goals;Grant;Growth;Health;Health Campaign;health difference;High Prevalence;Hispanic;Inflammation;Insulin Resistance;International;Intervention;Juice;Latino;Leadership;Link;lipid biosynthesis;Liver diseases;Machine Learning;Medicine;Mentors;Mentorship;Metabolic dysfunction;Metabolic Pathway;Metabolism;Michigan;Midcareer Investigator Award in Patient-Oriented Research;Molecular Genetics;Names;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;next generation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional Science;Obesity;Obesity Epidemic;obesity in children;patient oriented;patient oriented research;pediatric department;Phenotype;Physiological;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;prepuberty;Prevalence;prevent;Prevention;Prevention strategy;Prevention trial;programs;pubertal timing;Public Health;Publications;randomized, clinical trials;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Science;Series;Severities;Siblings;skills;Strategic vision;sugar;Syndrome;Testing;Time;Training;Translational Research;trial comparing;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Weight Gain;Woman;Workplace;Youth

PROJECT_TITLE: Patient-Oriented Research for Cardiometabolic Health in Children

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The proposed research is important to public health because it focuses on α-synuclein (αS), a central protein implicated in Parkinson’s disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), and certain forms of Alzheimer’s disease (AD). The applicants have developed a unique set of experimental ap- proaches to distinguish normal and abnormal Serine129 phosphorylation in αS since this post-translational mod- ification is not only a principal component of “Lewy bodies”, pathological αS deposits in diseased brains, but also has a physiological role in healthy neurons. Therefore, the proposed research is relevant to NIA’s “AD/ADRD” mission of seeking fundamental knowledge to reduce the burden of PD, PDD, DLB, and AD in patients.

PI_NAMEs: RAMALINGAM, NAGENDRAN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: 1-Methyl-4-phenylpyridinium;Acceleration;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Back;Biochemical;Biological;Biology;Brain;Brain Diseases;Calcineurin;Calcium;cell type;Cells;Classification;Complex;Data;Dementia;Dementia with Lewy Bodies;Deposition;Disease;Disease Marker;Dissociation;dopaminergic neuron;Electrodes;Electrophysiology (science);Engineering;Environmental Risk Factor;epoxomicin;Event;Exocytosis;Foundations;Future;gain of function;genetic risk factor;Goals;Health;Homeostasis;Impairment;innovation;insight;Investigation;Knock-in Mouse;Knowledge;lactacystin;Lewy Bodies;Lewy Body Dementia;Lewy neurites;loss of function;Mediating;Methods;MG132;Missense Mutation;Mission;Modeling;Molecular;Molecular Profiling;mouse model;Multiple System Atrophy;Mutation;Neurons;neurotransmission;novel;Oligodendroglia;Other Genetics;Outcome;overexpression;Paraquat;Parkinson Disease;Parkinson's Dementia;patch clamp;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phosphorylation;Physiological;Physiology;Play;Post-Translational Protein Processing;pre-formed fibril;Predisposition;preservation;presynaptic;Process;Property;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Public Health;Recycling;Research;Rodent;Role;Rotenone;Serine;SNAP receptor;Solid;Surrogate Markers;Symptoms;Synapses;Synaptic Transmission;Synaptic Vesicles;synucleinopathy;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time;Toxin;Variant;Work

PROJECT_TITLE: Distinguishing α-Synuclein S129 Phosphorylation in Health and Lewy Body Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: Gut integrity is markedly worsened following sepsis, the leading cause of death among critically ill patients. Cancer is the most common comorbidity in sepsis, and the presence of malignancy results in significant alterations in both immunity and gut integrity. This program seeks to understand mechanisms through which sepsis alters gut integrity and through which cancer worsens outcomes in order to uncover new potential therapeutic targets to improve outcomes in a disease that is very common and highly lethal.

PI_NAMEs: COOPERSMITH, CRAIG M (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adaptive Immune System;Antibiotic Therapy;Antibiotics;Apoptosis;bench to bedside;beneficiary;Blood;Cause of Death;Chronic;Clinical;Clinical Data;comorbidity;cost;Critical Illness;Disease;Distant;Elements;Epithelium;experimental study;Feces;Functional disorder;General Population;Goals;high risk;Human;Immunity;improved outcome;In Vitro;in vivo;Individual;insight;Intestines;Malignant Neoplasms;Medicare;microbiome;migration;Morbidity - disease rate;mortality;mortality risk;Motor;Mucosal Immune System;Multiple Organ Failure;Organ;Outcome;Patients;Permeability;Play;precision medicine;Process;programs;Proliferating;Public Health;Role;Sampling;Sepsis;septic patients;Supportive care;Syndrome;Techniques;Therapeutic;therapeutic target;United States;young adult

PROJECT_TITLE: The Gut as a Target to Improve Outcomes in Sepsis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Regenerative Medicine;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Emergency hematopoiesis induces the rapid expansion of inflammatory neutrophils during infection, a process which must remain tightly regulated as the overproduction of hyperactivated granulocytes underlies the disease progression of systemic inflammation into septic shock. Therefore, myeloid progenitor fate during emergency granulopoiesis must be carefully controlled at a molecular, cellular, and systemic level. This proposal aims to examine the machinery that regulates the dramatic shift in myelopoiesis towards emergency neutropoiesis, with the goal of targeting this pathway to reduce the adverse effects of an over-activated immune system during septic shock.

PI_NAMEs: TRZECIAK, ALISSA JANE (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adverse effects;Affect;Biology;Blood Cells;Bone Marrow;Cell Count;Cell Fractionation;Cell Lineage;Cells;Chlorides;Colony-Stimulating Factor Receptors;Communication;Complex;cost;cytokine;Cytokine Receptors;Data;Deterioration;Development;directed differentiation;Disease Progression;Embryonic Development;Emergency Situation;Ensure;Event;Exhibits;Extracellular Fluid;Extracellular Space;functional genomics;Genes;GFI1 gene;Goals;granulocyte;Granulopoiesis;Growth Factor;Hematopoiesis;Hematopoietic;Homeostasis;Immune;Immune system;Immunity;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Innate Immune Response;Invaded;Link;Lysine;Macrophage;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Mediating;Mentors;metabolomics;Methods;Modeling;Molecular;monocyte;mortality;mouse model;Multipotent Stem Cells;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;neutrophil;Neutrophilia;novel;organ growth;Output;pathogen;Pathogenicity;Pathway interactions;Phase;Phosphorylation;Phosphotransferases;pluripotency;postnatal;Preparation;Process;Production;progenitor;programs;Proliferating;Regulation;Reporting;Research;response;Role;Sepsis;Septic Shock;Shunt Device;Signal Pathway;Signal Transduction;skills;small molecule;stem cell differentiation;stem cell fate;Stimulus;Systemic infection;systemic inflammatory response;Techniques;Testing;Tissues;tool;transcription factor;Transcriptional Regulation;Treatment Factor;uptake;Work

PROJECT_TITLE: WNK1-dependent macropinocytosis mediates emergency myelopoiesis

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE. Blood-based biomarkers have the potential to transform diagnosis and clinical management of Alzheimer’s disease in the community, but it is unclear how these biomarkers perform in diverse populations. We plan to investigate the effects of various sociodemographic and medical factors on the performance of plasma p- tau217, a promising new blood-based biomarker for Alzheimer’s disease. Results from this study will ultimately contribute to improved early identification and screening for Alzheimer’s disease in communities that are disproportionately affected by the disease.

PI_NAMEs: BOLTON, COREY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adult;Affect;African American;Aging;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Autopsy;base;behavior change;Biological Assay;Biological Factors;Biological Markers;Biometry;Black race;Blood;Blood specimen;Blood Tests;blood-based biomarker;cardiovascular risk factor;career;Chronic Kidney Failure;Cirrhosis;Clinical;clinical implementation;Clinical Management;Cognitive;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Consensus;cost;Cox Proportional Hazards Models;Data;Data Analyses;Dementia;dementia risk;Development;Diagnosis;Disclosure;Disease;Disparity;Early Diagnosis;Early identification;Early Intervention;early screening;Ensure;Epidemiology;Equipment;Ethnic Origin;experience;Funding;Future;Goals;Head;Health;Health behavior;Health Planning;improved;in vivo;Income;Individual;Individual Differences;Institution;International;Intervention;Kidney;Kidney Diseases;Knowledge;Leadership;Linear Regressions;Liver diseases;Long-Term Care;Longitudinal cohort;Low income;Measures;Mediator;Medical;Medicare claim;Memory;Mentors;Mentorship;Methods;Modeling;motivated behavior;neighborhood disadvantage;neuron loss;Obesity;older adult;Participant;Pathology;Performance;Phenotype;Plasma;Population;Population Heterogeneity;Procedures;Productivity;programs;Public Health;Race;racial difference;racial disparity;racial diversity;racial population;Research;Resources;Risk;Risk Reduction;Scientist;screening;single molecule;skills;sociodemographics;Southeastern United States;success;tau-1;Technical Expertise;Tennessee;Threonine;tool;Training;training opportunity;underserved community;United States National Institutes of Health

PROJECT_TITLE: Examining the influence of sociodemographic and medical factors on plasma p-tau217 performance in diverse communities

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cardiovascular;Genetics;Heart Disease;Human Genome;Immunotherapy

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposal for mentored career development is designed to train the principal investigator in order to confer the skills necessary to be a successful independent investigator. The first focus is on commitment to ensuring that the principal investigator receives the mentorship and training to address any gaps in technical knowledge and ensure attainment of skills required of an independent biomedical investigator. The second focus is on understanding unexplored mechanisms by which a new combination immunotherapy (OX40 activation+PD-1 inhibition) reshapes the cardiac immune landscape and promotes myocardial vulnerability.

PI_NAMEs: MA, PAN  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Acute;Address;Adoptive Transfer;Adverse event;Advisory Committees;Agonist;Angiotensin II;Antibodies;Antigen-Presenting Cells;antitumor effect;Antitumor Response;Award;Blocking Antibodies;Cardiac;Cardiovascular system;career;career development;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint therapy;chemokine;Chronic;Clinical;clinical application;clinical investigation;Clinical Trials;clinically relevant;Clonal Expansion;Clonality;Clone Cells;Combination immunotherapy;Computational Biology;cytokine;Data;Data Set;design;Doctor of Philosophy;early phase clinical trial;effector T cell;Ensure;Eragrostis;Event;Exposure to;Fibrosis;Flow Cytometry;Frequencies;Future;gain of function;Genetic Transcription;Goals;Grant;Heart;Heart Diseases;Heart Hypertrophy;Immune;immune checkpoint;Immune response;immune-related adverse events;Immunology;Infiltration;Inflammation;Inflammatory;Infusion procedures;inhibitor;Injury;innovation;Intervention;Investigation;Knowledge;Link;Long-Term Effects;Macrophage;Maps;Memory;Mentors;Mentorship;Modeling;Molecular;monocyte;Mononuclear;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;myocardial injury;new technology;Oncology;OX40;Pathogenicity;Pathologic;Phagocytes;Phenotype;Phenylephrine;Population;post-doctoral training;preclinical study;prevent;Principal Investigator;programmed cell death protein 1;Proliferating;Proteomics;Rag1 Mouse;recruit;Regulatory T-Lymphocyte;Research;Research Personnel;Risk;Shapes;skill acquisition;skills;Specific qualifier value;success;Surface;T cell clonality;T cell receptor repertoire sequencing;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Technical Expertise;Techniques;Testing;Therapeutic;therapeutic target;Time;Training;transcriptomics;treatment effect;Treatment Protocols;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor necrosis factor receptor superfamily member 4;Writing

PROJECT_TITLE: Emerging Immune Checkpoint Therapies Reshape the Cardiac Immune Landscape and Promote Myocardial Vulnerability


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Pregnancy

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The lack of appropriate dosing information in pregnant individuals with uncontrolled asthma is an unmet public health need that can result in therapeutic failure and death. This proposal will build a framework for the use of physiologically based pharmacokinetic (PBPK) modeling for pregnant individuals with asthma. These developed PBPK models can be broadly applied to inform dosing of other drugs, improve outcomes in pregnant individuals, and further the NIH’s mission to reduce illness and disability.

PI_NAMEs: JOB, KATHLEEN MARIE (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adult;Affect;Anatomy;appropriate dose;Area;Asthma;asthma model;Binding Proteins;Biological;Blood flow;career;career development;Cessation of life;Chronic;Chronic Disease;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Collection;Creatinine clearance measurement;Data;design;Development;disability;Dose;dose information;drug action;drug disposition;Drug Exposure;Drug Kinetics;Drug Modelings;Drug Prescriptions;efficacy trial;Equilibrium;Ethics;Event;Exposure to;Failure;FDA approved;fetal;Fetus;fluticasone;Future;Goals;Health;Human;improved outcome;Incidence;Individual;Infant;inflammatory marker;Inhalation;Injury;innovation;Interdisciplinary Study;interest;Leadership;Leukotriene Antagonists;Link;Literature;maternal morbidity;Maternal-fetal medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolism;Methodology;Methods;Mission;Modeling;montelukast;Mothers;Occupations;Organ Size;Outcome;participant enrollment;patient oriented;Pharmaceutical Preparations;pharmacodynamic model;Pharmacoepidemiology;pharmacokinetic model;Pharmacology;pharmacometrics;Phase;Physiological;physiologically based pharmacokinetics;Physiology;Population;predictive modeling;Pregnancy;pregnant;programs;prospective;Prospective Studies;Public Health;Regimen;Research;research and development;Research Design;Research Personnel;Safety;Sampling;Science;skill acquisition;skills;Special Population;Specialist;standard of care;Surveys;Symptoms;Techniques;Therapeutic;Time;Toxic effect;Training;Treatment Failure;United States;United States National Institutes of Health;Venous blood sampling

PROJECT_TITLE: Physiologically-Based Pharmacokinetic (PBPK) Modeling of Asthma Drugs during Pregnancy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Lack of contraceptive autonomy is associated with health inequities and adverse health outcomes ranging from STIs to depression to low birth weight. However, without the tools to measure contraceptive autonomy, researchers and policymakers are left without a clear idea of where and how contraceptive autonomy is lacking, and which sociodemographic groups are most affected. The study proposed here will develop and validate a standardized metric of contraceptive autonomy, documenting reproductive inequities and situating the multidimensional construct of autonomy within cultural context.

PI_NAMEs: SENDEROWICZ, LEIGH GABRIELLE (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Affect;Age;Burkina Faso;career;career development;Coercion;cognitive interview;Collaborations;comparative;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Country;Data;Data Set;Decision Making;Demographic and Health Surveys;design;Development;Dimensions;Disincentive;Disparity;Economics;empowerment;Equity;Ethnic Origin;Ethnic Population;Evaluation;Exposure to;Extended Family;Family Planning;Family Planning Center;Family Planning Programs;Fertility;Fostering;Funding;Future;global health;Goals;Grant;Health;health disparity;health inequalities;Health Planning;Health Priorities;Health system;improved;Incentives;Individual;Inequity;instrument;intergenerational;Interview;Kenya;Left;Low Birth Weight Infant;marginalization;Measurement;Measures;Mental Depression;Mentors;Methodology;Methods;Modeling;Monitor;Montana;Nepal;novel;Outcome;patient oriented;person centered;Personal Satisfaction;Persons;Policy Maker;population based;Population Study;Positioning Attribute;prevent;Program Evaluation;programs;psychologic;Psychometrics;Public Health;Quality of Care;racial population;reproductive;reproductive coercion;Reproductive Health;Research;Research Personnel;Respondent;Rights;Risk;Sampling;scale up;Sexually Transmitted Diseases;Site;social culture;sociodemographic group;sociodemographics;Standardization;Structure;Surveys;Techniques;Testing;Time;tool;Training;Training Activity;Training Programs;Translational Research;Universities;Update;uptake;Validation;validation studies;Wisconsin;Woman

PROJECT_TITLE: Contraceptive Autonomy: A Mixed-Methods Approach to Developing a Novel Family Planning Measure

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The communities of microbes that inhabit our bodies modulate our immune systems with remarkable precision leading to the generation of antigen-specific responses in the absence of inflammation or barrier breach. This proposal seeks to uncover the function and molecular mechanisms elicited by the skin microbiota on the immune system and leverages this knowledge to develop non-invasive approaches to induce targeted immune responses. Overall, this work lays the foundation for a novel vaccination modality against viral and bacterial infections.

PI_NAMEs: BOUSBAINE, DJENET  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Affect;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Award;B cell repertoire;B-Lymphocyte Epitopes;B-Lymphocytes;Bacteria;bacterial genetics;Bacterial Infections;Bacterial Model;Biochemical;Biochemistry;Biomedical Research;cancer therapy;career;Cell Wall;Cells;Cellular biology;Cold Chains;commensal bacteria;commensal microbes;Communicable Diseases;Complement;Complex;Cutaneous;Data;Development;disease transmission;draining lymph node;Electron Microscopy;Engineered skin;Engineering;Formulation;Foundations;Generations;Genetic;Genetic Engineering;Goals;gut bacteria;gut inflammation;Herd Immunity;Human;Human Volunteers;Immune;Immune response;Immune system;Immune Targeting;Immunity;Immunology;Infection;Inflammation;Influenza A virus;insight;Intramuscular;Knowledge;Label;low and middle-income countries;Memory;Mentors;Methods;Microbe;microbial community;Microbiology;microbiome therapeutics;microbiota;microbiota composition;Modality;Modeling;Molecular;mouse model;Mucosal Immunity;mucosal vaccination;mucosal vaccine;Mucous Membrane;Mus;Needles;new technology;novel;novel vaccines;pathogen;pathogenic bacteria;pathogenic virus;Pathology;Positioning Attribute;programs;Proteins;Research;response;Role;single-cell RNA sequencing;Site;Skin;skin barrier;Skin colonization;skin microbiome;skin microbiota;Staphylococcus aureus infection;Staphylococcus epidermidis;Structure of germinal center of lymph node;success;Surface;T cell response;Technology;Testing;Time;Tissues;tool;Training;Vaccinated;Vaccination;vaccination strategy;vaccine development;vaccine strategy;Vaccinee;Vaccines;vaccinology;Viral;Viral Antigens;Virus Diseases;Work

PROJECT_TITLE: Probing and engineering the B cell response to the skin microbiota

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This study will use a combination of qualitative and quantitative methods to develop and validate a measure of structural gendered racism (cross cutting racism and sexism) and determine the impact of early life exposure on Black women’s cognitive aging and risk of Alzheimer’s disease and related dementia (ADRD). This proposal will also leverage data collected from the Health and Retirement Study to identify categorically distinct subgroups of older Black women whose exposure patterns to gendered racism in early life differ, and examine associations with cognitive baseline, cognitive decline, and incident ADRD. Results of the study will include the development of a novel index that can be used longitudinally to track changes in Black women’s exposure to structural gendered racism over the lifecourse and illumination of modifiable structural mechanisms that, with intervention and public policy, may reduce the disproportionate burden of ADRD in a historically marginalized subgroup.

PI_NAMEs: HILL-JARRETT, TANISHA G (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;aged;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Black American;black men;Black race;black women;brain health;Childhood;Civil Rights;Classification;Code;Cognitive;Cognitive aging;cognitive performance;Comparative Study;Criminal Justice;Data;Data Set;dementia risk;Development;Diagnosis;Dimensions;Disadvantaged;Disparity;Dose;early childhood;early life exposure;Education;ethnic minority population;experience;Exposure to;Failure;Focus Groups;Gender;gender disparity;Geographic Locations;Geography;Goals;Group Interviews;Grouping;Health;Health and Retirement Study;Healthcare;Heterogeneity;high risk;Housing;Impaired cognition;improved;indexing;Intervention;Interview;Investigation;late life;leadership development;Life;Life Cycle Stages;Lighting;Link;Lived experience;marginalization;Measurement;Measures;Memory;Memory Loss;men;Methodology;Methods;middle age;Modeling;Nature;neighborhood disadvantage;Neurocognitive;Neuropsychology;novel;Outcome;Participant;Pathway interactions;Pattern;Performance;Policies;Process;psychologic;psychosocial;Public Policy;Race;racial disparity;racial minority population;racism;remediation;Research;Research Design;Research Methodology;Research Personnel;response;Role;Sampling;Scientist;sex;Sexism;Social Conditions;social determinants;Social Environment;Social Policies;Statistical Methods;Statutes and Laws;structural determinants;Structural Racism;Subgroup;System;Testing;Training;Training Activity;Typology;United States;Validation;Vulnerable Populations;White Women;Woman

PROJECT_TITLE: Measuring the Impact of Structural Gendered Racism on Black Women’s Cognitive Aging and Risk of Alzheimer’s Disease and Related Dementia: A Mixed-Methods Investigation


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pneumonia;Pneumonia and Influenza;Precision Medicine

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Community-acquired pneumonia is one of the most common infections among children in the United States. However, accurately diagnosing community-acquired pneumonia can be challenging due to its similarity with other common respiratory infections, resulting in misuse of diagnostic tests and overuse of antibiotics. The proposed research will develop a prediction model for community-acquired pneumonia using data from the electronic health record and design a clinical decision support system that will improve use of radiographs and antibiotics, thus improving health outcomes of children with this infection.

PI_NAMEs: RAMGOPAL, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acceleration;Accident and Emergency department;accurate diagnosis;Active Learning;acute care;Address;advanced analytics;Age;Antibiotics;antimicrobial;Area;Artificial Intelligence;Artificial Intelligence enhanced;Attention;Award;Benchmarking;career;career development;Caring;Chest;Child;Childhood;Clinical;clinical care;clinical decision support;Clinical Decision Support Systems;Clinical Informatics;Clinical Investigator;clinical practice;clinical predictive model;clinical predictors;community acquired pneumonia;computer human interaction;cost;Data;Data Sources;Decision Making;Dedications;design;Development;Development Plans;Diagnosis;Diagnostic tests;Discrimination;Disease;Educational workshop;electronic health data;Electronic Health Record;Emergency Medicine;Emergency Situation;Ensure;Environment;evidence base;experience;Funding;Goals;Guidelines;Health;Health system;high risk;Hospitalization;Hospitalized Child;human centered design;implementation science;improved;Individual;Infection;Informatics;Infrastructure;innovation;Institution;Intervention;iterative design;Knowledge;Lead;Lower Respiratory Tract Infection;Machine Learning;Medical;Mentors;Mentorship;Methodology;Methods;model building;Modeling;Morbidity - disease rate;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Parents;Pathway interactions;Patients;pediatric emergency;Pediatric Hospitals;Perception;Performance;Physicians;Positioning Attribute;precision medicine;Predictive Analytics;predictive modeling;prospective;prototype;Radiation exposure;Receiver Operating Characteristics;Recommendation;Registries;Research;Research Activity;Research Personnel;research study;Resolution;Resources;respiratory;Respiratory Tract Infections;Retrospective cohort study;Risk;Scientist;skills;Structure;Techniques;Technology;Testing;Time;tool;Training;United States;United States National Institutes of Health;Universities;usability;Validation;Work

PROJECT_TITLE: Precision medicine approaches in the diagnosis of community-acquired pneumonia in children

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Maternal infection during pregnancy increases the risk of neuropsychiatric disease/disorders in offspring; however, maternal immune activation does not induce neurodevelopmental disorder vulnerability in the majority of offspring. Here, we test whether maternal immune activation acts as a ‘priming event’, increasing susceptibility to subsequent risk factors such as early-life stress, exposure to which has been shown to increase susceptibility to neuropsychiatric disorders. In this R21 proposal, we will test the hypothesis that a two-hit model of maternal immune activation using toll-like receptor 7 activation during pregnancy in combination with early-life postnatal resource deprivation stress results in sex-specific neurodevelopmental vulnerabilities.

PI_NAMEs: BORDT, EVAN ANDREW (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Agonist;Anterior;Bacteria;Beds;Behavior;Behavioral;Biological Assay;Blood;Brain;brain cell;Caring;Cells;chemokine;cingulate cortex;Cognition Disorders;Cognitive;Coupled;cytokine;Data;deprivation;developmental disease;Diet;Disease;Double-Stranded RNA;early life adversity;early life stress;Embryo;Emotional;Emotional disorder;Endotoxins;Environment;epidemiology study;Etiology;Event;excitatory neuron;Excitatory Synapse;Exposure to;Female;fetal;Homelessness;Housing;Human;Hypothalamic structure;Imiquimod;Immune;immune activation;Immune response;Immune system;Immunologic Sensitization;Impairment;in utero;Infection;Infectious Agent;Inflammatory;inflammatory milieu;Inflammatory Response;Influenza;Inhibitory Synapse;Injections;Life;Link;Lipopolysaccharides;Macrophage;male;maltreatment;Maternal Behavior;Microglia;mimetics;Modeling;Morphology;mouse model;neglect;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;offspring;paraventricular nucleus;Perinatal;perinatal period;Phagocytosis;Placenta;Play;Poly I-C;postnatal;Poverty;Predisposition;Pregnancy;pregnant;prenatal;Process;Production;Regulation;Resources;response;Risk;Risk Factors;RNA;Rodent;Rodent Model;Role;Rubella;sex;Sex Bias;social;Social Behavior;Stress;stress related disorder;stressor;Synapses;Testing;Time;TLR3 gene;TLR4 gene;TLR7 gene;Ventral Tegmental Area;Virus;Work

PROJECT_TITLE: Defining the Neuro-Immune and Placental Profile of a Dual-Hit Toll-like Receptor 7 and Stressor Mouse Model

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Telehealth

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed K23 study will significantly contribute to public health by assessing the needs of a minoritized population, Hispanic informal caregivers of patients with ADRD, and culturally tailoring an existing caregiver mobile intervention with the long term goal of providing a scalable and effective intervention for this population.

PI_NAMEs: RODRIGUEZ, MIRIAM JOCELYN (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;African American;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer's disease related dementia;Behavior;Behavior Therapy;Behavioral Model;Behavioral Symptoms;bilingualism;Brain;career;career development;Caregiver Burden;caregiver interventions;Caregivers;caregiving;caucasian American;Clinical Investigator;Clinical Trials;Cognition;cohort;Communities;community based service;cultural values;culturally appropriate intervention;Data;Dementia;Dementia caregivers;design;Devices;Diagnosis;Distress;effective intervention;Effectiveness;Effectiveness of Interventions;Ensure;Equipment and supply inventories;Equity;experience;Family;Family Caregiver;feasibility testing;Funding;Future;Goals;Habits;handheld mobile device;Health;health application;health care service;Hispanic;Hispanic Americans;Hispanic Populations;Home;Hour;improved;Individual;informal caregiver;Internet;Intervention;Interview;iterative design;Knowledge;Language;Latino Population;Lead;Lived experience;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Minority Groups;Modeling;Modification;Native-Born;Needs Assessment;Nervous System Physiology;neuropsychiatry;Not Hispanic or Latino;Outcome;Participant;Patients;Persons;Pilot Projects;pilot test;Population;Population Intervention;psychologic;psychological symptom;Public Health;Randomized, Controlled Trials;recruit;remote health care;Reporting;Research;Research Personnel;Resources;retention rate;Sampling;Secure;Spanish;Structure;symptomatology;Symptoms;telehealth;Testing;therapy development;Training;Translating;Translations;United States National Institutes of Health;usability

PROJECT_TITLE: Cultural adaptation of a mobile caregiver intervention for Hispanic dementia caregivers


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The contribution of lifecourse income to late life risk for Alzheimer’s Disease and Related Dementias (ADRD) is not known. The parent grant will tackle this research gap by creating a pooled, synthetic cohort with data that spans the full lifecourse. This diversity supplement research project will validate the parent study’s pooling method using valid and accurate income data from the social security administration (SSA) data linked to the Health and Retirement Study (HRS). Furthermore, this project will evaluate the association of lifecourse income data from the SSA and, separately, the pooled, synthetic cohort with cognition, ADRD risk, and mortality.

PI_NAMEs: GLYMOUR, MEDELLENA MARIA;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adult;Age;age related;Aging;aging related;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Blood Vessels;Cognition;cohort;Cohort Studies;Data;Data Pooling;Data Security;Dementia;dementia risk;Disease;Education;emerging adult;Future;Health and Retirement Study;health data;Impaired cognition;Income;innovation;late life;Life;Life Cycle Stages;Link;low socioeconomic status;Measures;Methods;middle age;mortality;National Longitudinal Survey of Youth;Outcome;parent grant;Parents;Participant;Patient Recruitments;Patient Self-Report;Pattern;Population;Prevalence;Research;Research Project Grants;Retirement;Risk Factors;Security;social;social epidemiology;Time;Training;United States Social Security Administration;Validation

PROJECT_TITLE: Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related Disorders


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative Poor sleep during cocaine abstinence is one of the strongest predictors of return to use (relapse). The current project will use cutting edge approaches to characterize how cocaine alters the function of a brain neuropeptide system critical for arousal. These studies will contribute to the development of novel medications to treat cocaine use disorder.

PI_NAMEs: ASTON-JONES, GARY S. (contact);JAMES, MORGAN H.

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;antagonist;Arousal;Behavior;behavioral economics;Binding;Brain;Cell Count;Chronic;Clinical Management;Cocaine;cocaine relapse;cocaine self-administration;Cocaine use disorder;Data;Development;Dose;Drug usage;Electroencephalography;Electromyography;Event;Exhibits;experimental study;FDA approved;Fiber;Future;Genetic;genetic approach;Goals;hypocretin;Hypothalamic structure;improvement on sleep;Lateral;Link;Literature;Measures;Mediating;Mediator;Motivation;National Institute of Drug Abuse;Neurobiology;Neurons;Neuropeptides;non rapid eye movement;novel;novel strategies;orexin 1 receptor;orexin B receptor;Outcome;Pharmaceutical Preparations;Phenotype;Photometry;poor sleep;Population;Prediction of Response to Therapy;prevent;Rattus;receptor;Regulation;Relapse;relapse prediction;Reporting;return to use;Rewards;Role;Schedule;sensor;Signal Transduction;Site;Sleep;Sleep Architecture;Sleep disturbances;Sleeplessness;System;Testing;Therapeutic;Time;Training;treatment duration;Treatment Protocols;Ventral Tegmental Area;virtual;Wakefulness;Work

PROJECT_TITLE: Orexin (hypocretin) signaling in ventral tegmental area as a common mediator of sleep disturbances and drug demand in cocaine abstinence

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Kidney Disease;Neurosciences;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Lipoic acid, an over-the-counter dietary supplement, is associated with NELL1 membranous nephropathy, an autoimmune kidney disease characterized by urine protein loss (proteinuria), and at late stages, kidney failure. In this proposal we will determine the relationship among NELL1 antibodies, proinflammatory T cells, and proteinuria in people who use lipoic acid. This research has the potential to identify early-stage disease in lipoic acid users and unmask important treatment targets to prevent kidney failure.

PI_NAMEs: AVASARE, RUPALI  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Address;Adult;Affect;Antibodies;Antibody Response;Antigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;B cell therapy;B-Lymphocytes;Biological Markers;Blood;Blood coagulation;CD4 Positive T Lymphocytes;Cells;Characteristics;chronic pain;Clinical;clinical risk;Computerized Medical Record;Counseling;cytokine;Data;design;dietary supplements;Diffuse;Disease;Disease remission;Drug Exposure;Dyslipidemias;early detection biomarkers;Early Diagnosis;Early identification;Edema;End stage renal failure;Environmental Risk Factor;Epidermal Growth Factor;experience;Fc Receptor;Feasibility Studies;Female;Flow Cytometry;Foundations;Funding;Future;Goals;high risk;Immune;Immune Tolerance;Immunologic Markers;Immunologics;Inflammatory;Institution;Investigation;K-Series Research Career Programs;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Lead;Leadership;Longitudinal cohort;Longitudinal Studies;Manuscripts;Marketing;Measures;Mediating;Medical;Medical Research;Membranous Glomerulonephritis;Mentors;Mentorship;neural;Neuropathy;novel;Observational Study;Oregon;pathogen;Pathogenicity;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Phospholipase A2;Play;podocyte;Population;pre-clinical;Predisposition;Prevalence;prevent;Proteins;Proteinuria;Rare Diseases;receptor;recruit;Regulatory T-Lymphocyte;Reporting;Research;Resources;Risk;Risk Factors;Role;Science;Serum;sex;Spain;Specific qualifier value;Sulfhydryl Compounds;Swelling;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Thioctic Acid;Thrombosis;Training;translational scientist;Urine;Western Blotting;Woman

PROJECT_TITLE: Mechanisms of autoimmune dysregulation in lipoic acid users at risk for NELL1 membranous nephropathy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Patients with ALK+ lung cancer experience variable levels of tumor control when treated with tyrosine kinase inhibitors (TKI), and our data suggest neutrophils within the tumor microenvironment can reduce patient response to TKI. Using immunocompetent mouse models and patient specimens, this proposal will determine how neutrophils dampen TKI response. These insights will support future clinical trial approaches with novel immunotherapies not yet considered in patients with ALK+ NSCLC.

PI_NAMEs: SCHENK, ERIN L (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;anaplastic lymphoma kinase;Antitumor Response;Biological Models;Biopsy;cancer cell;Cancer Center;Cancer Model;career;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chemotactic Factors;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Colorado;comparison control;CXCL1 gene;CXCL2 gene;CXCL5 gene;cytokine;cytotoxicity;Data;Development;Diagnostic;Disease;Disease Progression;Environment;Exhibits;experience;Flow Cytometry;Future;genetic approach;Genetic Transcription;Goals;IL8 gene;Immune;Immune system;Immunocompetent;Immunologics;Immunologist;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;in vivo;Infiltration;inhibitor therapy;innovation;insight;Institution;International;Investigation;Knowledge;Laboratories;Malignant neoplasm of lung;Mediating;Medical Oncology;Mentors;Modeling;molecular targeted therapies;mouse model;Mus;NCI-Designated Cancer Center;neutrophil;Neutrophil Infiltration;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;oncology program;patient population;patient response;Patient-Focused Outcomes;Patients;PD-1/PD-L1;Persons;Phenotype;Physicians;Positioning Attribute;pre-clinical;Production;Publishing;Qualifying;Research;Resource Sharing;response;Role;Scientist;Shapes;single-cell RNA sequencing;skills;Spatial Distribution;Specimen;survival outcome;T cell response;T-Lymphocyte;technology platform;Testing;Thoracic Oncology;Tissue imaging;Toxic effect;transcriptomics;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;Tyrosine Kinase Inhibitor;Universities;Work

PROJECT_TITLE: Tumor Microenvironment Determinants of TKI Response in Oncogene-Driven Lung Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Lupus

ORG_CITY: DAYTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Environmental exposure to ultraviolet (UV) radiation mediates systemic inflammatory responses in susceptible individuals with photosensitive autoimmune disease, yet mechanisms of signal transduction are poorly understood. We present evidence that exposure to UVB results in release of photoproduct-containing DNA in extracellular vesicles, and photoproducts can be detected in the lymphatic systems of mice and in urine of human subjects. The proposed research seeks to understand the mode of circulation and impact of extracellular damaged DNA in the context of photosensitive autoimmune disease and contribute to better diagnostics and treatments for sensitizing exposures to environmental genotoxins.

PI_NAMEs: CARPENTER, MAE ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: adduct;Autoantibodies;Autoimmune;Autoimmune Diseases;autoinflammatory diseases;Award;Biology;Biometry;Cell Culture Techniques;Cells;Chemistry;Chromatin;Circulation;Clinical Trials;Cutaneous Lupus Erythematosus;Dermatomyositis;Diagnostic;Diffuse;Digestion;Disease;Distal;DNA;DNA Adducts;DNA Damage;DNA damage checkpoint;Education;Environment;Environmental Exposure;Epidemiology;Excretory function;Exonuclease;Exposure to;extracellular;extracellular vesicles;Genome;Health;Health Sciences;Human;human subject;Human Subject Research;immunogenic;improved;In Vitro;indexing;Individual;Inflammation;Inflammatory Response;Interferon Type I;Interferons;keratinocyte;Kinetics;Libraries;Lupus;lymph nodes;Lymphatic System;Maps;Measures;Mediating;Mediation;Mediator;Medical;Modeling;mouse model;Mus;Mutagens;National Institute of Environmental Health Sciences;new therapeutic target;nuclease;Organ;particle;Pathway interactions;Patients;Photosensitivity;Phototherapy;Ploidies;population health;Predisposition;Public Health;Pyrimidine Dimers;Research;research faculty;response;Role;Serum;Severity of illness;Shock;Signal Transduction;Signaling Molecule;Skin;Specimen;Stimulator of Interferon Genes;systemic inflammatory response;Systemic Lupus Erythematosus;Testing;TLR7 gene;Training;Translational Research;Travel;ultraviolet;Ultraviolet B Radiation;ultraviolet damage;Ultraviolet Rays;Universities;Urine;UV induced;UV Radiation Exposure;Work

PROJECT_TITLE: Systemic travel of damaged DNA in photosensitive autoimmune disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-S (99)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (AD/ADRD) are predicted to increase substantially, yet how early life risks work together with midlife and late-life modifiable factors to alter AD/ADRD risk is unclear. The proposed project will leverage twin and sibling data, with genomic data, to evaluate life course risk and protective factors for AD/ADRD, testing causal hypotheses and gene-environment interplay. Converging evidence from our approaches will inform clinical and policy recommendations regarding life course risk and protective factors that create differential vulnerabilities for AD/ADRD.

PI_NAMEs: NEIDERHISER, JENAE M.;REYNOLDS, CHANDRA A (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adoption;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;Attention deficit hyperactivity disorder;Australia;autism spectrum disorder;Bereavement;Body mass index;Cessation of life;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive reserve;cohort;Country;Data;dementia risk;Denmark;depressive symptoms;Development;Dimensions;Disparity;early life adversity;Education;emotional factor;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;foster care;Genes;Genetic;Genetic Risk;genomic data;Goals;Guide prevention;Health;Health behavior;healthy lifestyle;high body mass index;high risk;Individual;Inequity;Influentials;Intervention;late life;Life;Life Cycle Stages;life span;Link;Marital Status;Measures;Mediating;Mendelian randomization;Mental Depression;Methods;middle age;Modeling;modifiable risk;Monozygotic twins;neurodevelopment;Neurodevelopmental Disorder;novel strategies;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Physical activity;physical conditioning;policy recommendation;Population;Positioning Attribute;prospective;protective factors;Research;Research Personnel;research study;resilience;Risk;Risk Factors;Role;Sampling;Schools;sex;Siblings;social;social engagement;Social Environment;Social isolation;Socioeconomic Status;socioeconomics;Structure;Sweden;System;Testing;Twin Multiple Birth;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Gene-environment Interplay Among Modifiable Factors for AD/ADRD: Risk and Resilience Across the Lifespan

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Sleep disruption commonly occurs during opiate withdrawal and elevates the probability of relapse. This application will elucidate the circuit mechanism underlying opioid withdrawal-induced sleep disturbances. We will determine whether and how locus coeruleus-centering arousal circuits become dysfunctional during opioid withdrawal and expected results will reveal novel circuit-based strategies for treating sleep disruption in Opioid Use Disorder (OUD).

PI_NAMEs: ZHONG, PENG  (contact)

PROJECT_TERMS: Abstinence;Affect;Arousal;Brain;Calcium;calcium indicator;Cell Nucleus;Cells;Characteristics;Chronic;Clinical Research;craving;CRISPR/Cas technology;Cytoplasm;Development;Dose;effective therapy;Electrophysiology (science);Fiber;Gene Expression;Genes;Genetic;genetic approach;Genetic Markers;Heterogeneity;in vivo;Individual;Label;locus ceruleus structure;long term abstinence;Maps;Mediating;Membrane;Modeling;Molecular;Molecular Profiling;Monitor;Morphine;morphine administration;mouse model;Neurobiology;neuromechanism;Neurons;Neurosciences;Neurotransmitters;noradrenergic;Norepinephrine;novel;olfactory stimulus;Opiate Addiction;Opioid;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Opsin;optogenetics;patch sequencing;Pathway interactions;Patients;Phase;Photometry;Population;preclinical study;presynaptic;prevent;Probability;Property;Regulation;Relapse;relapse risk;Reporter;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;Sleep;Sleep Disorders;Sleep disturbances;Sleep Wake Cycle;Sleeplessness;Slice;Symptoms;System;Tactile;Techniques;Testing;tool;transcriptome sequencing;transcriptomics;vestibular system;Viral;Visual;Wakefulness;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Mechanistic studies of opiate withdrawal-induced sleep disturbances


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Genetics;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Mitochondria regulate metabolism, the process that changes food to energy and if people have abnormal or missing copies of the genes required for mitochondrial function they will develop primary mitochondrial disease for which there are neither cures nor treatments. Many patients with mitochondrial disease have neurologic symptoms, so to understand how mitochondrial dysfunction causes neurologic problems, this proposal studies mitochondrial metabolism in neurons. Successful completion of the proposed studies would result in advancing both the understanding and methods for studying mitochondrial metabolism in the brain, with the goal of translating these findings into treatments for patients with mitochondrial diseases.

PI_NAMEs: MITHAL, DIVAKAR SINGH (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Applications Grants;Boston;Brain;Brain region;Brain Stem;brain tissue;career;Cell Nucleus;Cell Survival;cellular targeting;Cerebellum;Child;Chronic;Citric Acid Cycle;Clinical;Collaborations;Complex;Critical Care;Data;Dedications;Defect;design;disease heterogeneity;disease phenotype;Electron Transport;excitatory neuron;experience;experimental study;extend lifespan;Food;Foundations;Functional disorder;Funding;Future;gamma-Aminobutyric Acid;Genes;Genetic;Genetic Diseases;genomic locus;Glutamates;Goals;Health;Heterogeneity;Hippocampus;Human;human disease;human stem cell-derived;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Incidence;induced pluripotent stem cell;Inpatients;Interneurons;Intravenous infusion procedures;Knock-out;Label;Laboratories;Learning;Lesion;Live Birth;Measurement;Measures;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mortality;mouse model;Mus;Natural regeneration;Neurologic;Neurologic Symptoms;Neurologist;neuronal circuitry;neuronal survival;Neurons;Neurosciences;Nicotinamide adenine dinucleotide;Outpatients;oxidation;Oxidoreductase;Patients;Pattern;pediatric department;Pediatric Neurology;Pediatrics;Persons;pharmacologic;Phenocopy;Phenotype;Physicians;Play;Population;postnatal;Prevalence;Process;Production;professor;Program Development;Proton Pump;Proton-Motive Force;Regulation;Research;Role;Scientist;Seizures;skills;Symptoms;System;Techniques;Testing;therapeutic target;Time;tool;Transfection;Translating;translational scientist;Universities;Vision;Work

PROJECT_TITLE: Mitochondrial Metabolic Regulation of GABAergic Interneurons

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Alzheimer's Disease (AD) is the most common cause of dementia, and it disproportionately affects African Americans and Hispanics. Emerging data suggest that the “causal” pathological markers of AD, as defined by the AT(N) framework (Amyloid, Tau, Neurodegeneration) vary by race/ethnicity. The current grant will examine the role of the exposome, and its link to the ATN framework, in the risk of developing AD among the three ethnic groups.

PI_NAMEs: GERMAN, DWIGHT C. (contact);JONES, DEAN PAUL;RICHARDSON, JASON R

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Aducanumab;Affect;African American;African American population;Age;aging brain;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Area;Aromatic Hydrocarbons;Biological;Biological Markers;Biostatistics Core;Blood;Blood specimen;Blood Vessels;Chemicals;Clinical;Clinical Trials;cognitive change;cognitive function;cohort;Communities;comparison control;Data;Dementia;deprivation;environmental chemical;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Epidemiology;ethnic difference;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Flame Retardants;fungicide;Future;Gas Chromatography;Genetic;Genomics;Grant;Health;Health Disparities Research;health disparity;Herbicides;Hispanic;Hispanic Populations;Human;Image;Impaired cognition;indexing;Inflammatory;Informatics;Insecticides;Knowledge;Life Cycle Stages;Link;Liquid substance;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Metabolic;metabolomics;Methods;Mexican Americans;multi-ethnic;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychology;Not Hispanic or Latino;novel;organochlorine exposure;Outcome;Participant;Pathologic;Pathway interactions;Patients;pesticide exposure;Pesticides;Pharmaceutical Preparations;Plasticizers;polybrominated diphenyl ether;Polychlorinated Biphenyls;Population;Population Heterogeneity;Populations at Risk;Positron-Emission Tomography;Proteomics;Race;racial difference;racial population;Research;Resolution;Risk;Risk Factors;Role;Sampling Studies;social culture;Solvents;Systems Biology;tau Proteins;Testing;Work

PROJECT_TITLE: Environmental Exposome as a Driver of Race/Ethnicity Differences in Alzheimer's Disease

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Microbiome;Nutrition;Substance Misuse;Transplantation

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Fecal microbiota transplant (FMT) is a promising therapeutic for alcohol misuse. FMT in patients suffering from alcohol use disorder (AUD) reduced craving for alcohol, improved transplant-free survival, reduced rates of infections, and this drinking reduction could be transmitted to mice where drinking was also reduced as compared to untreated donors. This proposal will use behavioral and genomic approaches in a murine model to test the composition of individual human donor samples which will reduce drinking in mice; dietary fiber will also be used to test for relative enhancement of engraftment and further reductions in drinking.

PI_NAMEs: BAJAJ, JASMOHAN S (contact);WOLSTENHOLME, JENNIFER T

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Adult;Affect;alcohol behavior;Alcohol consumption;alcohol craving;alcohol misuse;alcohol relapse;alcohol use disorder;Alcoholic Liver Diseases;Antibiotics;Anxiety;anxiety-like behavior;associated symptom;Bacteria;bacterial community;Behavioral;behavioral pharmacology;Brain;Butyrates;Carbohydrates;Characteristics;Chronic;chronic liver disease;Cirrhosis;Clinical;Clinical Research;Clinical Trials;Data;Defect;Diet;Dietary Fiber;Donor person;Donor Selection;drinking;drinking behavior;dysbiosis;effective therapy;effectiveness evaluation;Engraftment;Evaluation;experimental study;fecal transplantation;Feces;Female;Fiber;Genomic approach;Germ-Free;Growth;gut microbiome;gut microbiota;gut-brain axis;Heavy Drinking;Human;Immune;Immune response;improved;Individual;infection rate;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Intervention;intestinal barrier;Intestinal permeability;Investigation;Laboratories;laboratory experience;Leaky Gut;Length;Liver;Liver diseases;male;Mediating;Mental Depression;metagenomic sequencing;Metagenomics;microbial;microbiome;microbiome alteration;microbiome research;microbiota;microbiota transplantation;Modeling;Motor Activity;mouse model;Mus;neuropsychiatric symptom;Patients;Pharmacotherapy;Phenotype;Population;Pre-Clinical Model;preclinical study;preference;Production;Reaction;Rodent;Role;Sampling;Sex Differences;Shotguns;Signal Transduction;Testing;Therapeutic;Therapeutic Uses;Time;transmission process;Transplantation;transplantation therapy;Volatile Fatty Acids;Work

PROJECT_TITLE: Evaluation of individual FMT as a potential therapeutic to reduce ethanol drinking in mice

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project narrative 20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to develop an intelligent clinical decision support system to help clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don’t, thus improving patient safety while reducing blood waste and healthcare costs.

PI_NAMEs: LOU, SUNNY S. (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Adoption;Anemia;Antibodies;Artificial Intelligence;Artificial Intelligence enhanced;artificial intelligence model;Blood;Blood Donations;blood product;Blood Transfusion;Blood typing procedure;Blood Volume;care costs;career;career development;Caring;Characteristics;Clinic;clinical decision support;Clinical Decision Support Systems;clinical decision-making;Clinical Pathways;clinical practice;Clinical Research;Clinical Trials;Cluster randomized trial;cost;Data;Data Science;Data Set;Decision Making;design;Development Plans;Discrimination;Doctor of Philosophy;Effectiveness;effectiveness/implementation hybrid;Electronic Health Record;Emergency Situation;Environment;Equilibrium;Erythrocytes;Evaluation;experience;Frequencies;Future;Goals;hazard;Health Care Costs;Health Technology;Healthcare;Hour;human centered design;implementation evaluation;implementation framework;implementation science;implementation strategy;improved;Informatics;Infrastructure;innovation;Intervention;Interview;Judgment;Life;Logistic Regressions;Measures;Mentors;Mentorship;Methods;model development;Modeling;multidisciplinary;Names;Operating Rooms;Operative Surgical Procedures;Outcome;Participant;patient safety;Patients;Perioperative;personalized decision;personalized medicine;pilot trial;point of care;Pragmatic clinical trial;predictive modeling;Preparation;primary outcome;Procedures;Process;programs;prototype;Public Health;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Training;Risk;Risk Estimate;risk prediction;safety outcomes;Science;screening;secondary outcome;Site;skill acquisition;skills;standard of care;support tools;surgical risk;Techniques;technological innovation;Testing;Time;tool;Training;Transfusion;transfusion medicine;treatment as usual;United States;Universities;Washington;Waste Products;wasting;Work

PROJECT_TITLE: Intelligent Clinical Decision Support for Perioperative Blood Management

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE We have little knowledge of factors that promote optimal neurodevelopmental outcomes in opioid-exposed infants. In this K23, we propose incorporating lived experience through an active partnership with a local community advisory board with an innovative focus on positive experiences in an established, large prospective longitudinal birth cohort of children with neonatal opioid withdrawal syndrome. Our investigation of children who exhibit positive adaptation in the face of biological and social adversity will identify specific protective or promotive factors for optimal neurodevelopment in this high-risk population which could serve as future intervention targets.

PI_NAMEs: BENNINGER, KRISTEN L (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 3 year old;6 year old;Academic achievement;Address;Adult;adverse childhood events;Affect;Age;Area;Behavior;Biological;Birth;Buffers;Caregivers;Child;Child Rearing;Childhood;Cognitive;cohort;Communities;community advisory board;community engaged research;community partners;Competence;Complex;Data;design;Development;Diagnosis;early childhood;Educational workshop;efficacy testing;Emotional;Ethics;Evaluation;executive function;Exhibits;experience;Exposure to;Family;Feedback;Feeling;fetal opioid exposure;follow-up;Foundations;Functional disorder;Funding;Future;Goals;Health;Health Care Rationing;health care service utilization;high risk population;Hospital Costs;improved;in utero;Individual;Infant;innovation;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Language;Lead;Linear Regressions;Lived experience;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Measures;meetings;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Modification;Motor;multidisciplinary;Neonatal Abstinence Syndrome;Neonatology;neurodevelopment;neurodevelopmental effect;Neurodevelopmental Impairment;neuroimaging;Neuropsychology;Newborn Infant;novel;opioid exposure;Outcome;Parent-Child Relations;Patient-Focused Outcomes;Phase;Populations at Risk;postnatal;pre-clinical;preference;prevent;Procedures;Process;programs;prospective;Prospective cohort;Psychology;Public Health;Recording of previous events;recruit;Reporting;Research;Research Design;resilience;Risk;Risk Factors;School-Age Population;social;social adversity;sociodemographic factors;socioeconomics;Standardization;Stress;Structure;symposium;Testing;tool;Training;training opportunity;Translations;Treatment Efficacy;Voice;Work

PROJECT_TITLE: Optimizing Developmental Outcomes in Early Childhood After Neonatal Opioid Withdrawal Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Cardio and cerebrovascular risk factors (CVRFs) such as hypertension, diabetes, heart disease, obesity, and stroke increase the risk of Alzheimer's disease (AD). This project uses cutting-edge multi-omics data in humans with advanced statistical methods to identify novel genes that interact with CVRFs in AD using GWAS and to identify epigenomic and transcriptomic profiles, and integrative pathways in AD that interacts with vascular pathologies. My findings may elucidate how genes and CVRFs interplay to influence AD risk, provide insights into the racial/ethnic disparities in AD, suggest personalized strategies for preventing AD in elderly individuals with CVRFs, and reveal novel molecular targets for potential AD treatment.

PI_NAMEs: LEE, ANNIE J (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Advisory Committees;African American population;Age;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;ancestry analysis;Autopsy;Big Data;Bioinformatics;Biological;Biometry;Blood Vessels;Body mass index;Brain;Candidate Disease Gene;career development;Case/Control Studies;causal variant;cerebrovascular;cerebrovascular pathology;Clinical;cohort;Communities;Compensation;Complex;Computational Biology;Data;Data Analyses;Data Set;Dementia;dementia risk;Development Plans;Diabetes Mellitus;Diagnosis;Disease;DNA Methylation;Educational workshop;effective therapy;Elderly;Environment;Epidemiology;Epigenetic Process;epigenomics;ethnic disparity;ethnic diversity;Ethnic Population;Etiology;FMNL2 gene;Funding;gene discovery;Gene Expression;gene interaction;Genes;Genetic;genetic architecture;genetic association;genetic variant;genome wide association study;genome-wide;Goals;Heart Diseases;Heritability;high risk;Hispanic Populations;Human;Hypertension;Immune system;improved;Individual;insight;Investigation;Knowledge;Leadership;Measurement;Measures;Mediation;meetings;Memory;Mentors;Meta-Analysis;Methods;Methylation;Molecular;Molecular Target;multi-ethnic;Multiomic Data;multiple omics;Neurology;Neurons;Not Hispanic or Latino;novel;Obesity;Pathologic;Pathology;Pathway interactions;Patient Self-Report;personalized diagnostics;personalized strategies;Pharmaceutical Preparations;Population;Prefrontal Cortex;Prevalence;prevent;Prevention;Prevention strategy;Process;Quantitative Trait Loci;racial disparity;racial diversity;religious order study;Research;Research Personnel;Research Project Summaries;Risk Factors;Sample Size;Sampling Studies;Scientist;sex;Signal Transduction;skills;SNP genotyping;Statistical Methods;Stroke;Techniques;Testing;Training;Transcript;transcriptomics;treatment strategy;United States National Institutes of Health;Universities;Vascular Diseases

PROJECT_TITLE: Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk Factors

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  Dr. Abbott’s K08 research project addresses critical gaps and known disparities in out-of-hospital cardiac arrest (OHCA) clinical outcomes and survival through the development and testing of enhanced predictive models that include pre-hospital, patient-level, hospital-level and individual-level health-related social needs (HRSN) data. Using natural language processing (NLP) and large language models (LLMs), mediation analysis, and machine learning algorithms, his study will advance current predictive models improving clinical care and survival for OHCA patients. His research will result not only in important knowledge and techniques regarding the inclusion of HRSN for OHCA care, but also set the stage for his subsequent R01-supported study to externally validate in other health systems the HRSN-inclusive models from this K08 research project.

PI_NAMEs: ABBOTT, ETHAN  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Admission activity;Affect;Algorithms;Area;beneficiary;Black race;Cardiac Catheterization Procedures;career;career development;Caring;Cessation of life;Characteristics;Clinical;clinical care;clinical predictors;cohort;community setting;Consumption;Data;Data Science;Data Set;Development;Development Plans;Disparity;efficacy evaluation;Electronic Health Record;Emergency Medicine;experience;Faculty;food insecurity;Goals;hazard;Health;health assessment;health equity;Health Services Accessibility;Health system;Healthcare;Hospital Mortality;Hospitalization;Hospitals;Housing;housing instability;Implantable Defibrillators;improved;Individual;Information Retrieval;innovation;Intervention;Knowledge;large language model;Leadership;machine learning algorithm;Manuals;mathematical model;Mediation;Medical;Medicare;Mentorship;Methodology;Methods;Modeling;mortality;multidisciplinary;Natural Language Processing;Neighborhoods;Neurological outcome;novel;out-of-hospital cardiac arrest;Outcome;Patient Care;Patients;Performance;Persons;Physicians;Positioning Attribute;Predictive Analytics;predictive modeling;Principal Investigator;prospective;Public Health;Racial Segregation;readmission risk;Research;Research Personnel;Research Project Grants;residence;Resuscitation;Role;Scientist;skills;social;survival prediction;Techniques;Temperature;Testing;Time;Training;Transportation;transportation access;United States;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Addressing Disparities in Out-of-Hospital Cardiac Arrest: Utilization of Health-Related Social Needs and Predictive Analytics to Improve Clinical Outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Palliative Care;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it identifies the needs of family caregivers of persons living with dementia (PWLD) who suffer from urinary incontinence, the interpersonal dynamics of these care dyads (caregiver-PLWD), and potential targets for future interventions to support them. The ultimate goal of this research is to improve in-home continence care support for all parties and to keep PWLD living in their homes for as long as possible. Thus, the proposed research is relevant to the NIA’s mission to improve our knowledge and to develop more effective ways to care for older adults, in particular, those living with Alzheimer’s Dementia and their family caregivers.

PI_NAMEs: SUSKIND, ANNE M.;YANK, VERONICA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Alzheimer's Disease;Appearance;Area;Assisted Living Facilities;California;caregiver education;caregiver interventions;Caregiver support;Caregivers;caregiving;Caring;Child;Child Support;cohort;Communities;community setting;Data;Daughter;Dedications;Dementia;dementia care;Dementia caregivers;design;Disease;Disease Progression;empowerment;Enrollment;experience;Face;Family;Family Caregiver;Family member;family support;Focus Groups;Friends;Future;Goals;Health;Health Professional;Health Promotion;Health system;Home;Home environment;Husband;improved;Incontinence;Individual;Injury;innovation;insight;Institutionalization;Intervention;Interview;Knowledge;Loneliness;loved ones;lower urinary tract symptoms;men;Mental Depression;Methodology;Mission;Nature;Needs Assessment;novel;Odors;older adult;Parents;Participant;Personal Satisfaction;Persons;Photography;preference;preservation;Public Health;recruit;Reporting;Research;Research Methodology;Resources;Rural;rural area;Rural Community;Safety;San Francisco;skills;Social isolation;Son;Spouses;Stigmatization;Stress;therapy development;tool;Training;underserved area;Universities;Urban Community;Urban Population;urban setting;Urinary Incontinence;Violence;Voice;Vulnerable Populations;Wife;Woman

PROJECT_TITLE: Improving Incontinence Support for Family Caregivers and Persons Living with Dementia

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Early identification of children at high risk of deterioration is a challenge, but a data-driven approach that incorporates high-frequency physiological data from bedside monitors will improve our ability to identify this at- risk population. The proposed work will derive, validate, and design for the implementation of a machine learning-based prediction model that identifies mechanically ventilated children at risk of new or worsening cardiorespiratory dysfunction. This is a critical step towards implementing acceptable and effective real-time, longitudinal prediction models at the bedside of the critically ill child.

PI_NAMEs: BADKE, COLLEEN M (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;Age;Area;Award;biomedical informatics;Calibration;Cardiovascular system;Child;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinical practice;clinical predictive model;clinical predictors;clinical risk;cohort;Critical Care;Critically ill children;Data;Data Analyses;Death Rate;design;Deterioration;disability;Early identification;Early Intervention;effectiveness testing;experience;Foundations;Frequencies;Functional disorder;Goals;health care delivery;heart rate variability;high risk;high risk population;Hour;implementation design;implementation science;improved;improved outcome;innovation;Intervention;Intervention Studies;Intervention Trial;Lead;Machine Learning;machine learning prediction;Measures;Mechanical ventilation;Mentored Patient-Oriented Research Career Development Award;Modeling;Monitor;mortality;mortality risk;novel;Organ;Outcome;Patient-Focused Outcomes;Patients;Pediatric Hospitals;performance tests;personalized care;personalized health care;Physiologic Monitoring;Physiological;Physiology;Populations at Risk;predictive modeling;Predictive Value;programs;public health relevance;Publishing;Research;Respiration Disorders;respiratory;Risk;Risk Assessment;ROC Curve;support tools;Survivors;Testing;therapy design;Time;Training;usability;user centered design;Validation;Work

PROJECT_TITLE: Predicting Clinical Deterioration in Mechanically Ventilated Children using High-Frequency Physiologic Data

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: NARRATIVE Progressive pulmonary fibrosis encompasses a broad range of diseases with a shared progressive phenotype for which there is no cure. This application seeks to address a fundamental gap in knowledge about how fibroblasts gain BCL-2 mediated resistance to apoptosis through persistent IL-6 signaling. The results of our studies will provide insight into targeting IL-6 signaling in fibroblasts to therapeutically restore fibroblast sensitivity to apoptosis as a treatment for progressive pulmonary fibrosis.

PI_NAMEs: COOLEY, JOSEPH CHARLES (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Address;Apoptosis;Apoptotic;autocrine;Automobile Driving;Award;BCL1 Oncogene;BCL2 gene;Behavior;Biological;Biometry;Bleomycin;Board Certification;career;career development;Cell Culture Techniques;Cell Death;Clinical;clinically relevant;Collaborations;Colorado;Contracts;Critical Care;Data Analyses;Dependovirus;Deposition;Development;Development Plans;Disease;disease phenotype;Distal;Doctor of Philosophy;Dose;Educational workshop;effective therapy;Effector Cell;Environment;Epigenetic Process;Experimental Designs;Extracellular Matrix;Family member;Fellowship;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;fibrotic lung disease;follower of religion Jewish;Gene Transfer;Gene Transfer Techniques;Genetic;Genomics;Goals;Granulation Tissue;Health;Human;idiopathic pulmonary fibrosis;IL-6 inhibitor;In Vitro;in vivo;Inflammation;insight;Institution;instructor;Interleukin-6;Interruption;Interstitial Lung Diseases;Investigation;Knock-out;Knowledge;Laboratories;Leadership;Lung;lung injury;Mediating;medical schools;Medicine;meetings;Mentors;Mentorship;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Oral;overexpression;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Process;profibrotic fibroblast;Proteins;Publications;Pulmonary Fibrosis;Recording of previous events;repaired;Reporter;Research;Research Personnel;Research Project Grants;Residencies;Resistance;Resistance development;Resolution;response;Role;Scientist;Severities;Signal Transduction;skills;Slice;STAT3 gene;symposium;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Training;transcription factor;Transcriptional Activation;translational physician;Universities;Viral Vector;Work;wound;wound healing;Writing

PROJECT_TITLE: Bcl-2 dependent fibroblast resistance to apoptosis occurs through persistent IL-6 signaling