NIH_SPENDING_CATS: Brain Disorders;Hematology;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: VERSITI WISCONSIN, INC.

PHR: PROJECT NARRATIVE Platelets circulate in the bloodstream and, when they encounter a damaged blood vessel, become activated and stick together to help to plug up the damaged area and stop bleeding; excessive bleeding occurs when platelet counts are too low, which is a condition referred to as thrombocytopenia. This application represents a unique application of hematology and immunology expertise required to tackle unresolved problems in the immunologic bleeding disorder Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), which is a non- malignant hematologic disease that arises when the immune system of a pregnant person makes antibodies that clear a baby's platelets before or immediately after birth. We are especially interested in determining why FNAIT develops in some at-risk pregnancies but not others and why some babies with FNAIT experience excessive bleeding in the brain, referred to as intracranial hemorrhage, which can result in irreversible brain damage and death.

PI_NAMEs: NEWMAN, DEBRA KAY (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: adverse pregnancy outcome;Affect;Alleles;Alloantigen;Alloimmunization;Animal Model;Antibodies;Area;at-risk pregnancies;Binding;Birth;Blood Circulation;Blood Coagulation Disorders;blood damage;Blood Platelets;Blood Vessels;Brain Death;Brain hemorrhage;Brain Injuries;Breeding;Cessation of life;Circulation;Classification;Clinical;clinically relevant;clinically significant;comparative;Complex;CRISPR/Cas technology;cross reactivity;Development;Diagnosis;Diagnostic;diagnostic development;Diagnostic tests;dimorphism;Disease;disorder prevention;Dose;Endothelial Cells;Epitopes;Erythrocytes;Etiology;Event;experience;fetal;Fetal Development;Fetal Diseases;Fetus;fetus cell;First Pregnancy Trimester;Hematological Disease;Hematology;Hemorrhage;Hemorrhagic Complication of Pregnancy;high risk;Human;human disease;Human Platelet Antigens;human subject;humanized mouse;Immune response;Immune system;Immunization;Immunologics;Immunology;Impairment;improved;in vivo;indexing;Infant;Infusion procedures;Inherited;insight;Integrins;interest;Intracranial Hemorrhages;Intravenous Immunoglobulins;Isoantibodies;isoimmunity;ITGB3 gene;Knowledge;Label;Leucine;Life;Lifelong disability;Live Birth;Maternal antibody;Measures;Methods;Modeling;Molecular Biology;Morbidity - disease rate;mortality;Mothers;mouse model;Mus;Neonatal;Neonatal Alloimmune Thrombocytopenia;neonatal period;neonate;Newborn Infant;Non-Malignant;novel;off-label use;Organ;Pathology;Patients;Persons;Placenta;Plasma;Platelet Count measurement;Population;Positioning Attribute;pre-clinical;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;pregnant;Pregnant Women;prevent;Prevention;Prevention strategy;programs;Proline;prophylactic;Prophylactic treatment;Protocols documentation;Recommendation;Research;response;Risk;Scheme;Specificity;Syncytiotrophoblast;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Third Pregnancy Trimester;Thrombocytopenia;Transfusion;Transgenic Mice;Work

PROJECT_TITLE: Interrogating clinically relevant attributes of maternal alloimmunity in fetal/neonatal alloimmune thrombocytopenia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: We generated the first bisteric mTOR inhibitors, demonstrated their activity in GMB preclinically, and generated a strategy to potentiate efficacy in GBM while sparing mTOR inhibition outside the CNS; by dosing mice with both RapaLink-1 and a brain-impermeable FKBP12 ligand that we synthesized, called RapaBlock. A clinical bisteric mTOR inhibitor, RMC-5552, developed by Revolution Medicines, is currently in clinical trials, with a GBM trial to open in 2023. We hypothesize that: 1), RapaBlock will potentiate efficacy while decreasing peripheral toxicity of RMC-5552 in GBM, and 2), We can further develop our strategy to develop FKBP-dependent inhibitors of other prominent targets in GBM, including targets with liabilities outside of the CNS, initially focusing on inhibitors of JAK kinases that block activation of STAT3. 1

PI_NAMEs: FAN, QI WEN ;SHOKAT, KEVAN M.;WEISS, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affinity;Alzheimer's Disease;Automobile Driving;Binding;Binding Sites;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Cell Line;Cells;Central Nervous System;Chemotherapy and/or radiation;Clinical;Clinical Trials;Dasatinib;design;Dose;Dose Limiting;Drug Combinations;drug development;Drug Kinetics;electric field;Excision;Feedback;FK506;FRAP1 gene;Glioblastoma;Glioma;Helmet;Hematology;improved;in vivo;inhibitor;JAK1 gene;Janus kinase;kinase inhibitor;Ligands;Link;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Marketing;Medicine;Molecular Chaperones;Mus;neoplastic cell;neurotoxicity;Operative Surgical Procedures;Parkinson Disease;Pathway interactions;Patients;Penetration;Peripheral;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phosphotransferases;PIK3CG gene;pre-clinical;protein complex;Proteins;Proto-Oncogene Proteins c-akt;Reporting;Resistance;Risk;scaffold;Signal Pathway;Signal Transduction;Sirolimus;STAT1 gene;STAT3 gene;Tacrolimus Binding Proteins;Testing;Toxic effect;Xenograft procedure

PROJECT_TITLE: Brain-Restricted Kinase Inhibition with Binary Pharmacology

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Basal forebrain cholinergic neurons (BFCNs) are important for arousal, attention, learning, and memory, and they are prone to degeneration in Down syndrome (DS) and other neurodegenerative diseases. The F99 proposal will determine if there are fewer BFCNs at birth in DS and utilize iPSC models while the K00 proposal will expand this work to determine the temporal order of pathology accumulation in the DS basal forebrain and identify molecular mechanisms that may contribute to BFCN susceptibility. A better understanding of the role of BFCNs in disease progression may improve DS and other neurodegenerative disease models as well as elucidate novel therapeutic targets.

PI_NAMEs: WEST, NICOLE  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Age of Onset;age-related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Arousal;Attention;Autopsy;basal forebrain;basal forebrain cholinergic neurons;Birth;Brain;brain tissue;Caring;Cells;Characteristics;cholinergic;Chromosomes;Cross-Sectional Studies;Data;Dementia with Lewy Bodies;Development;Diagnosis;differential expression;Disease;disease model;Disease Progression;Down's Syndrome;Early Intervention;Fetal Development;Gene Expression Profile;General Population;Genes;Genetic;genetic risk factor;Goals;Health;High Prevalence;Hippocampus;Human;human stem cells;improved;In Vitro;Individual;induced pluripotent stem cell;Intellectual functioning disability;Knowledge;Learning;Life;Life Expectancy;life span;Live Birth;Maintenance;Medicine;Memory;Modeling;Molecular;Molecular Profiling;Nerve Degeneration;Nerve Growth Factors;Neurodegenerative Disorders;neurodevelopment;Neurofibrillary Tangles;neuron development;neuron loss;Neurons;new therapeutic target;novel;Output;Parkinson Disease;Pathology;Pathway interactions;Population;Postdoctoral Fellow;postnatal;pre-doctoral;Predisposition;Risk;Rodent Model;Role;Senile Plaques;stem cell model;tau Proteins;Testing;Therapeutic Intervention;Tissues;Trisomy;United States National Institutes of Health;Work

PROJECT_TITLE: Investigating the susceptibility of basal forebrain cholinergic neurons in individuals with Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (57)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Diabetes;Prevention

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: In this project, we develop and apply novel, robust, rigorous, and transparent statistical methods to identify for whom a surrogate marker can be used in place of an expensive or invasive outcome when the utility of the surrogate marker varies with multiple patient characteristics, and to formally investigate the impact of such complex heterogeneity on future trial design. The methods, software, and results of this study have the potential to inform and improve the design, content, and analysis of future studies aimed at diabetes prevention.

PI_NAMEs: PARAST, LAYLA  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Age;American;Body mass index;Characteristics;Chronic Disease;Clinical;Clinical Research;Clinical Trials;Complex;Computer software;Data;Decision Making;Dementia;design;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;Diagnosis;Effectiveness of Interventions;Face;fasting plasma glucose;Future;Goals;heart disease risk;Heterogeneity;Hormones;improved;Individual;innovation;Insulin;Intervention;Intervention Studies;Kidney Failure;Life Expectancy;Longterm Follow-up;Measurement;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Pancreas;patient subsets;Patients;Prevention strategy;Prevention trial;primary outcome;Quality of life;Research;Research Personnel;sex;Statistical Methods;Strategic Planning;Stroke;Subgroup;surrogacy;Surrogate Markers;Testing;Testosterone;treatment effect;treatment response;trial design;web app

PROJECT_TITLE: Robust Statistical Methods to Identify and Use Surrogate Markers in Diabetes

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH We have chosen to study leprosy, because it remains a global health burden on developing countries, because it provides an extraordinary model to study human immune responses to a microbial pathogen and because the lesions are readily accessible for study of immune processes at the site of disease. The investigation of how T cells are activated in leprosy and how they contribute to host defense against the bacteria that causes leprosy will provide new insights into the human immune system as well as provide novel targets for therapeutic intervention against a wide range of infectious diseases.

PI_NAMEs: MODLIN, ROBERT L (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Affect;antimicrobial;Antimycobacterial Agents;Bacteria;Bacterial Infections;Biological Assay;Biological Markers;Blood;cathelicidin;CCL1 gene;CCL20 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell secretion;Cell surface;Cells;Clinical;Communicable Diseases;CXCL13 gene;cytokine;Data;Developing Countries;Disease;drug development;Drug Targeting;Ecosystem;Endothelial Cells;Fibroblasts;Foamy Macrophage;Genes;Genus Mycobacterium;global health;granulysin;Host Defense;Human;human disease;Immune;Immune response;Immune system;Immunity;Immunohistochemistry;Immunosuppression;In Vitro;in vitro Assay;Infection;insight;Interferons;Interleukin-15;interleukin-21;Intervention;Investigation;keratinocyte;Lepromatous Leprosy;Leprosy;Lesion;Ligands;lipid metabolism;lipidome;Macrophage;Mediating;Methods;Modeling;Molecular;Molecular Analysis;Monitor;Mus;mycobacterial;Mycobacterium Infections;Mycobacterium leprae;Myeloid Cells;new therapeutic target;novel;oxidized lipid;pathogen;Pathogenesis;pathogenic microbe;Pathway interactions;Patients;Population;prevent;Process;Protein Secretion;Proteins;Public Health;Pulmonary Tuberculosis;Reaction;receptor;response;Role;Signal Transduction;single-cell RNA sequencing;Site;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Therapeutic Intervention;transcriptomics;TREM2 gene;Tuberculoid leprosy;Tuberculosis;vaccine candidate;vaccine development;vaccine evaluation;Vitamin D;XCL1 gene

PROJECT_TITLE: Molecular Analysis of Host Immune Response in Leprosy

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  The goal of the proposed research is to elucidate the cellular composition, detailed cellular morphology, and patterns of taste cell-to-nerve connectivity of murine fungiform taste buds. Several lines of evidence suggest that the fungiform taste buds of the anterior tongue might differ considerably from the circumvallate taste buds of the posterior tongue in both composition and function. A thorough examination of fungiform taste bud morphology would fill in a glaring gap in our anatomical understanding of the peripheral gustatory system in mammals.

PI_NAMEs: WILSON, COURTNEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Anterior;Apical;Area;Brain;Categories;cell type;Cells;Cellular Morphology;Central Nervous System;chorda tympani;Circumvallate Papilla;Code;Communication;connectome;Data;Data Analyses;Data Set;Detection;digital;Discrimination;Electrons;Esthesia;Face;Facial nerve structure;Fiber;Foliate Papilla;Fungiform Papilla;glossopharyngeal;Glossopharyngeal nerve structure;Goals;high resolution imaging;imaging software;Imaging Techniques;Individual;insight;interest;Ion Channel;Knowledge;Label;Literature;Machine Learning;Mammals;Manuals;Maps;Methodology;Modality;Molecular;molecular marker;Morphology;Mus;Nerve;Nerve Fibers;Neurons;novel;Nuclear Envelope;Oral cavity;Organ;Paper;Pattern;Peripheral;Physiological;Population;Process;Publishing;receptor;reconstruction;Reporting;Research;Resolution;response;Scanning Electron Microscopy;Sensory;Sodium Chloride;Stimulus;Structure;Subcategory;Subgroup;Synapses;System;Taste Buds;Taste Perception;taste system;Techniques;theories;three dimensional structure;Tissues;Tongue;Work

PROJECT_TITLE: Uncovering the ultrastructure and connectivity of murine fungiform taste buds

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project narrative Antiphospholipid antibodies can elevate the risk of blood clot formation. Unfortunately, existing treatment options in individuals with antiphospholipid antibodies have demonstrated limited effectiveness, as evidenced in antiphospholipid syndrome patients. This project introduces a novel approach that involves dual targeting of two essential coagulation factors to mitigate the risk of vascular thrombosis in individuals with prothrombotic autoantibodies.

PI_NAMEs: POZZI, NICOLA  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Active Sites;Affinity;Anti-phospholipid Syndrome;Anticoagulants;Anticoagulation;Antiphospholipid Antibodies;Autoantibodies;Autoimmune Diseases;Binding;Biochemical;Blood coagulation;Blood Coagulation Factor;Blood Vessels;Calcium ion;Cell membrane;Characteristics;Charge;Coagulation Process;Communicable Diseases;Complex;COVID-19;Cryoelectron Microscopy;design;Development;Economic Burden;Effectiveness;Elements;experience;Factor X;Factor Xa;Generations;Goals;Heparin;high risk;Human;Impairment;improved;improved outcome;In Vitro;Individual;innovative technologies;insight;Investigation;Laboratories;Lipid Binding;Mediating;Methods;Molecular Conformation;Monoclonal Antibodies;Names;nanobodies;nanomolar;novel strategies;Oral;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phospholipids;Plasma;Plasma Proteins;prevent;primary outcome;Process;Productivity;Property;Protein Family;Proteins;Prothrombin;Reaction;Reagent;recruit;Research;Research Project Grants;Resolution;Risk;risk mitigation;Series;Specificity;structural determinants;Structure;Surface;Technology;Testing;Therapeutic;Thrombin;Thrombosis;thrombotic;tool;Warfarin

PROJECT_TITLE: Introducing NanoProTEN, a novel approach for anticoagulation in patients with prothrombotic autoantibodies


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Caregiving Research;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: Project Narrative There is a need for accessible interventions to promote healthy growth and feeding practices in infancy to prevent later obesity. This proposal will evaluate an innovative virtual feeding intervention program for infants and their caregivers focused on optimizing infant breast-, bottle- and complementary feeding to support healthy growth and prevent obesity in the first two years. If effective, this program can be broadly disseminated to support healthy growth and obesity prevention.

PI_NAMEs: JACOBVITZ, DEBORAH B;WIDEN, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Adherence;Age;Anthropometry;Area;arm;attentional control;Behavior;Behavior assessment;Body Composition;Body fat;Body mass index;Body Weight Changes;Bottle feeding;Breast;Breast Feeding;Caregivers;caregiving;Characteristics;Child;Clinical;Complementary Feeding;contextual factors;Cues;design;Diet;Diet Habits;dietary;dietary guidelines;Dual-Energy X-Ray Absorptiometry;Eating;eating in absence of hunger;Educational Curriculum;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Enrollment;excessive weight gain;Family;feeding;Feeding behaviors;follow-up;Food;food insecurity;Fostering;Growth;Health;Healthy Eating;healthy weight;Hispanic;implementation fidelity;improved;Individual;infancy;Infant;Informal Social Control;injury prevention;innovation;Intervention;intervention effect;intervention program;Investments;Knowledge;Life;Life Cycle Stages;Low income;lower income families;Maintenance;Measurement;Measures;Mediation;Mental Depression;Modeling;modifiable behavior;Mothers;Newsletter;novel;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;Participant;Pathway interactions;Patient Self-Report;Pattern;Persons;Practical Robust Implementation and Sustainability Model;pragmatic trial;preference;Prevalence;prevent;primary caregiver;primary outcome;programs;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduced food intake;Research;Role;Safety;satisfaction;skills;sleep quality;Stress;successful intervention;Temperament;Testing;Text Messaging;Toddler;trial design;Underinsured;Uninsured;virtual;virtual intervention;Visit;Weight;Work

PROJECT_TITLE: Mothers and CareGivers Investing in Children: A virtual intervention to support healthy growth in infants and toddlers

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Autoimmune Disease;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE STATEMENT Neurodevelopmental disorders have become increasingly common, yet their causes remain largely unknown. The proposed research has the potential to identify immune and metabolic profiles during pregnancy that indicate risk for specific NDD. This would support the development of prenatal screening for NDD, leading to earlier intervention and the possibility of preventing future morbidity and improving quality of life.

PI_NAMEs: CROEN, LISA A (contact);VAN DE WATER, JUDY A.

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Antigen Targeting;Asthma;autism spectrum disorder;autistic children;Autoantibodies;Autoantibody binding;biobank;Biological Assay;Biological Markers;Blood specimen;Brain;California;Characteristics;Child;Child Development;Clinical;Clinical Research;clinical subtypes;cohort;Data;Development;Developmental Delay Disorders;Diagnosis;disorder risk;DNA binding protein B;Early identification;Early Intervention;Environment;Environmental Risk Factor;Etiology;fetal;First Pregnancy Trimester;Funding;Future;General Population;Genes;Genetic;genetic association;Gestational Diabetes;Goals;Grant;guanine deaminase;Health;Hypersensitivity;Immune;Immunologic Factors;Immunologic Markers;improved;Inflammation;Inflammatory;Intellectual functioning disability;Investigation;Joints;Knowledge;lactate dehydrogenase A;Language Delays;Maternal autoantibody;maternal immune system;maternal risk;Mediating;Mediator;Medical;Metabolic;Metabolic Marker;metabolic profile;Metabolic syndrome;modifiable risk;Morbidity - disease rate;Mothers;Motor;Names;Neonatal Screening;neurodevelopment;Neurodevelopmental Disorder;Neuron-Specific Enolase;novel;Obesity;offspring;Outcome;Overweight;pathogenic autoantibodies;Pattern;Phenotype;Phosphoproteins;Play;Population Control;postnatal;postnatal period;Pregnancy;prenatal;prenatal testing;prevent;Prevention;Primary Prevention;Production;programs;prospective;Proteins;Quality of life;recurrent infection;Research;Resources;response;Risk;Risk Factors;Role;Sampling;Second Pregnancy Trimester;Semaphorin-3A;Sensitivity and Specificity;sex;Statistical Data Interpretation;stem;Stress;study population;Subgroup;Testing;validation studies

PROJECT_TITLE: Maternal Autoantibody Reactivity, Gestational Inflammation, and Child Neurodevelopment (MARGIN)

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative A cell carefully regulates the transcription of each one of its many genes. In humans, abnormalities in this complex process (whether inherited or acquired) can lead to many diseases, including a variety of cancers. Plasticity in transcriptional circuitry is well documented in the progression of normal cells to cancer cells, and a deeper understanding of it will provide insights into recognizing and perhaps treating cases where it leads to aberrant physiologies.

PI_NAMEs: JOHNSON, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Amino Acid Sequence;Amino Acids;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Models;cancer cell;Candida;Case Study;Cells;chromatin immunoprecipitation;Code;combinatorial;Complement;Complex;Computing Methodologies;Controlled Study;Coupled;Disease;DNA;DNA Binding;DNA Binding Domain;Eukaryota;Evolution;experimental study;Frequencies;fungus;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene product;Genes;Genetic;genetic manipulation;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Grant;homeodomain;Human;Immunoprecipitation;Inherited;insight;Intuition;Lead;Malignant Neoplasms;Modeling;Modernization;Modification;Molecular;mutation screening;Normal Cell;Pattern;Phylogenetic Analysis;Physiology;Positioning Attribute;Probability;Process;Productivity;protein aminoacid sequence;protein complex;protein protein interaction;Proteins;Publications;reconstruction;Regulon;Roentgen Rays;Role;Saccharomyces cerevisiae;Source;Structure;Surface;Testing;Time;transcriptome sequencing;Trees;United States National Academy of Sciences;Variant;Work;Yeasts

PROJECT_TITLE: Mechanism of Yeast Transcriptional Regulators

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Our previous studies identified Natural Killer (NK) cells as important regulators of the immune response to cancer and responses to current FDA-approved immunotherapies. This research proposal will define novel cellular and molecular pathways that regulate the immunomodulatory effects of NK cells in the tumor microenvironment. This project will be the first steps towards the development of novel immunotherapies that harness the immunomodulatory effects of NK cells to increase patient’s immune responses to cancer.

PI_NAMEs: BARRY, KEVIN C (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Activated Natural Killer Cell;Address;Affect;anti-PD-1;anti-tumor immune response;Antigen-Presenting Cells;Antitumor Response;Biological Assay;Biological Response Modifiers;Cell Culture Techniques;Cell Shape;Cells;Cellular immunotherapy;checkpoint inhibition;chemokine;Clinic;Clinical;Combination immunotherapy;cytokine;Cytokine Signaling;cytotoxic;cytotoxicity;Data;Dendritic Cells;Development;Disease;Disseminated Malignant Neoplasm;Ecosystem;Ensure;FDA approved;FLT3 ligand;Gene set enrichment analysis;Human;Hypoxia;Image;Immune;Immune checkpoint inhibitor;Immune response;Immunology;immunoregulation;Immunotherapy;In Vitro;in vivo Model;Infection;Infiltration;Interleukin-15;Intrinsic factor;Ligands;Lymphocyte;Malignant Neoplasms;Measures;Melanoma;Melanoma patient;Metastatic Melanoma;Modeling;Molecular;mouse model;Mus;Natural Killer Cells;neoplastic cell;new therapeutic target;novel;novel therapeutics;Outcome;Output;Pathway interactions;patient response;Patients;Phenotype;Population;Population Heterogeneity;Production;Regulation;Research Proposals;response;Sampling;Shapes;Signal Pathway;Signal Transduction;Slice;Stat5 protein;synergism;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Techniques;transcriptome sequencing;transcriptomics;translational potential;treatment response;tumor;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Veins;Work

PROJECT_TITLE: Dissecting the immunomodulatory effects of NK cells on immune responses to cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is one of the most common causes of respiratory failure worldwide, but there are no disease-modifying therapies that have demonstrated efficacy. Alveolar macrophages (AMs) are an attractive therapeutic target for ARDS because they play a central role in almost all aspects of its pathophysiology. This project will determine the ontogeny and functional characteristics of AM subsets, and evaluate which subsets are robustly associated with ARDS clinical outcomes.

PI_NAMEs: MORRELL, ERIC DOUGLAS (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Admission activity;Alveolar;Alveolar Cell;Alveolar Macrophages;Animal Model;Bilateral;Biological Assay;Biology;Cell Lineage;Cell Ontogeny;Cell Surface Proteins;cell type;Cells;Characteristics;Chimerism;Clinical;clinically relevant;cohort;Computational Biology;cytokine;Data;Development;Disease;Embryo;Environment;Flow Cytometry;Functional disorder;Future;genomic variation;global health;Growth;Human;human model;Hypoxemia;Image;Immunology;improved;Inflammation;Inflammatory;Injury;innovation;insight;Intensive Care Units;Intervention Studies;Life;Lung;Lung Transplantation;Macrophage;Mechanical ventilation;Molecular Analysis;monocyte;mortality;multidisciplinary;Myocardial dysfunction;novel;Outcome;patient oriented;Patients;pharmacologic;Phenotype;Play;Population;programs;Property;Public Health;Publications;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Respiratory Failure;response;Role;self-renewal;single-cell RNA sequencing;Sorting;Source;Stains;Supportive care;T-Lymphocyte;Testing;therapeutic target;therapy development;Time;Transplant Recipients

PROJECT_TITLE: Alveolar macrophage subset ontogeny and differentiation during ARDS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Natural Products;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: HILO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HAWAII AT HILO

ORG_STATE: HI

PHR: PROJECT NARRATIVE - PUBLIC HEALTH RELEVANCE STATEMENT Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and it has defined risk factors, including hepatitis C virus (HCV)/hepatitis B virus (HBV) infection, liver cirrhosis and nonalcoholic steatohepatitis (NASH), making it a type of cancer which can clearly benefit from chemoprevention. TEA domain transcription factors (TEADs) bind to YAP/TAZ and mediate transcriptional output of Hippo pathway, and activation of TEAD-YAP complex has been shown to play an important role in HCC initiation. Hence, inhibition of TEAD palmitoylation could lead to the prevention of HCC initiation, which is highly relevant to public health.

PI_NAMEs: CAO, SHUGENG  (contact);CHEN, XIN ;WU, XU

PROGRAM_OFFICER_NAME: MOHAMMED, ALTAF

PROJECT_TERMS: Binding;Biochemical;Biological Assay;Biology;Cancer Etiology;cancer prevention;cancer type;Cells;Cessation of life;Chemicals;Chemoprevention;Chronic Hepatitis B;clinical development;combat;Complex;Cryoelectron Microscopy;Development;Disease;Docking;Dose;Drug Kinetics;experience;Follow-Up Studies;Genetic Transcription;Goals;Grant;Hawaii;Hawaiian;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;High Pressure Liquid Chromatography;high risk;high throughput screening;Human;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Intercept;interest;Lead;Libraries;Lipid Binding;Liquid Chromatography;Liver Cirrhosis;Liver neoplasms;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methods;Micro Electron Diffraction;microorganism;National Center for Advancing Translational Sciences;Natural product discovery;Natural Products;Natural Source;nonalcoholic steatohepatitis;novel;novel chemoprevention;Nuclear Magnetic Resonance;Output;Palmitoyl Coenzyme A;palmitoylation;Pathogenesis;Pathway interactions;Performance;Pharmaceutical Preparations;Play;Population;preclinical efficacy;preclinical toxicity;prevent;Prevention;Prevention trial;Preventive;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Properdin;Protein Isoforms;Public Health;public health relevance;Research;Risk Factors;Role;Sampling;Scheme;screening;small molecule;small molecule inhibitor;Source;Specificity;Structure;Toxic effect;transcription factor;tumorigenesis;Validation;Virus Diseases

PROJECT_TITLE: Discovery of novel natural TEAD inhibitors for the chemoprevention of liver tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J1)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Older adults are more vulnerable to health impacts from climate-related events such as hurricanes, floods, wildfires, and heat waves. This project provides important research infrastructure to improve understanding of these impacts and their implications. Through funding for pilot projects, training for researchers, and the development of useful publicly available data resources and tools, we enhance understanding of the public health consequences of environmental conditions and change across the US.

PI_NAMEs: BALK, DEBORAH L;HUNTER, LORI M. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;access restrictions;Adult;Aging;aging population;Archives;Area;base;Behavioral;career;Chronic Disease;Climate;climate change;climate data;climate impact;climate science;climate-related health;Code;Collaborations;Communities;computerized;Data;data integration;data platform;data resource;data sharing;Data Sources;data tools;data visualization;Death Rate;Demography;design;Development;Disasters;Discipline;Educational workshop;Electricity;Encapsulated;Ethnic Origin;Event;experience;Feedback;Floods;Fostering;Foundations;Funding;Future;gender diversity;Geography;Grant;Health;Health and Retirement Study;health disparity;Health Sciences;Heat Waves;Hurricane;improved;indexing;Indigent;Infrastructure;infrastructure development;Injury;innovation;insight;Institution;interdisciplinary approach;Interdisciplinary Study;interest;International;Investments;Knowledge;Link;Living Arrangement;Location;Measures;Medical;meetings;Mental Health;Methodology;mortality;National Archive;older adult;outreach;Phase;physical conditioning;Pilot Projects;Policies;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Public Health;Race;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;response;sample archive;Sampling;Scholarship;Scientist;social;Social isolation;Social Sciences;sociodemographics;Surveys;symposium;System;tool;Tornadoes;Training;virtual;weather-related disaster;web platform;webinar;Wildfire;Work

PROJECT_TITLE: Aging and Health in a Changing Climate

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (J1)]


ADMINISTERING_IC: CE

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: EAST LANSING

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Child sexual abuse (CSA) is preventable yet many existing programs focus on raising awareness regarding relevant risk and protective factors, rather than fundamentally shifting the contexts in which CSA takes place. The purpose of this community-partnered study is to evaluate the Public Will Campaign to End Child Sexual Abuse (PWC) for its effectiveness in building community connection, promoting collective efficacy, identifying and correcting misperceived social norms relative to CSA prevention, and ultimately, reducing CSA perpetration.

PI_NAMEs: MCCAULEY, HEATHER L (contact);SMITH-DARDEN, JOANNE P.

PROJECT_TITLE: CE21-006 - Cultivating Communities for Change:  Promoting Collective Action to Prevent Child Sexual Abuse


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Obesity continues to increase in children and is associated with increased metabolic risk. Oxytocin, a hypothalamic hormone that regulates eating behavior and energy metabolism, is a promising therapy to promote weight loss and improve metabolic risk in adolescents with obesity. This randomized placebo- controlled investigation will study the effects and underlying mechanisms of twelve weeks of intranasal oxytocin on weight and metabolic risk markers in adolescents with obesity 12-18 years old.

PI_NAMEs: BREDELLA, MIRIAM ANTOINETTE;LAWSON, ELIZABETH AUSTEN (contact);MISRA, MADHUSMITA

PROJECT_TERMS: 18 year old;Adolescence;Adolescent;Adolescent obesity;Adult;adult obesity;Animal Model;Anti-Inflammatory Agents;Automobile Driving;Behavior;Body Composition;Body mass index;Body Weight;Body Weight decreased;cardiometabolic risk;Child;comorbidity;critical period;Data;developmental plasticity;Diet;diet-induced obesity;Dose;Dual-Energy X-Ray Absorptiometry;Dyslipidemias;Early treatment;Eating;Eating Behavior;efficacy study;energy balance;Energy Intake;Energy Metabolism;Epidemic;Executive Dysfunction;Fasting;Fatty acid glycerol esters;food consumption;Food Energy;Heart Diseases;Hepatic;Hunger;Hypothalamic Hormones;Hypothalamic structure;Image;improved;Indirect Calorimetry;Individual;Inflammation;Interleukin-6;Intervention;intrahepatic;Investigation;late life;Life;lifestyle intervention;Lipids;Lipoproteins;Magnetic Resonance Imaging;Measures;Mediating;Medical;Metabolic;Monkeys;mortality;Motor Activity;muscle form;Neuroendocrine Therapy;neuroinflammation;Neurosecretory Systems;nonhuman primate;novel;novel therapeutics;obese patients;Obesity;obesity treatment;Overweight;Oxytocin;peptide hormone;Pharmaceutical Preparations;Physical activity;Physiological;Physiology;Placebo Control;Placebos;Population;preservation;prevent;Property;Quality of life;Randomized;randomized placebo controlled study;Randomized, Controlled Trials;Rattus;reduced food intake;Rest;Risk;Risk Marker;Rodent;Rodent Model;Safety;Serum;Single-Blind Study;systemic inflammatory response;Taste Perception;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Thermogenesis;Thinness;Time;TNF gene;Triglycerides;Visceral;Weight;Weight Gain;young adult;Youth

PROJECT_TITLE: Oxytocin as a Neuroendocrine Therapy for Obesity in Youth

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pediatric Cancer;Physical Activity;Precision Medicine;Prevention;Primary Health Care;Rare Diseases;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE  We propose to develop survivor-specific risk models to predict adverse outcomes of childhood cancer through collecting daily symptoms and other patient-generated health data (physical activity, sleep behavior, heart rate variability) using mobile health devices. We will apply machine/statistical learning methods to develop and validate risk prediction models, and use qualitative methods to receive input from clinicians and survivors for developing a user-friendly dashboard and decision support tools. Our risk prediction tool will facilitate informing individualized levels of specific adverse outcomes, and providing key information for clinicians and survivors to discuss in view of preventive interventions.

PI_NAMEs: HUANG, I-CHAN  (contact);YASUI, YUTAKA

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: 18 year old;Accelerometer;actigraphy;Adult;adverse event risk;adverse outcome;Age;Applications Grants;associated symptom;Attention;Behavioral;behavioral health;Biometry;cancer diagnosis;Cancer Survivorship;cancer therapy;cancer type;care providers;Caring;Cellular Phone;Cessation of life;childhood cancer survivor;Chronic;Clinical;Clinical assessments;Clinical Management;clinical outcome assessment;cohort;Cohort Studies;common symptom;Consultations;dashboard;Data;Data Collection;Devices;Diagnosis;Dose;Early Intervention;Education;Electronic Health Record;Eligibility Determination;Emergency department visit;Energy Metabolism;Enrollment;Environment;Evaluation;Fingers;Future;Genetic;Goals;Health;Health behavior;health care service utilization;health data;heart rate variability;Hospitalization;Hospitals;improved;Income;Intervention;Late Effects;learning strategy;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Medical;mHealth;Modeling;Monitor;Outcome;outcome prediction;Patient Monitoring;Patient Outcomes Assessments;patient portal;patient variability;Patients;Pattern;Performance;personalized risk prediction;Physical activity;Physical Performance;Pilot Projects;Population;predictive tools;premature;Prevention;preventive intervention;Primary Care;Process;Qualitative Methods;Quality of life;Reporting;Risk;Risk Factors;Risk Management;risk prediction;risk prediction model;Saint Jude Children's Research Hospital;sensor;Series;Severities;sex;sleep behavior;sociodemographic factors;sociodemographics;Specific qualifier value;statistical learning;support tools;Survivors;survivorship;Symptoms;Techniques;Testing;training data;user-friendly;Validation;wearable device;web-based tool;Wrist

PROJECT_TITLE: Patient-Generated Health Data to Predict Childhood Cancer Survivorship Outcomes


ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative The ACAD project will build the first major AD genetics study for Asians in US and Canada. Successful completion will lead to new genetic and lifestyle screening markers for Asian Americans and insights about novel therapeutic targets for AD. ACAD will be a first network for recruiting and studying AD in Asian Americans, serving the unmet needs of Alzheimer’s disease research for Asian Americans.

PI_NAMEs: CHUI, HELENA CHANG;JUN, GYUNGAH ;PARK, VAN MY TA;WANG, LI-SAN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;adjudication;Advocacy;Affect;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Area;Asia;Asian;Asian Americans;Asian population;Awareness;Biological Markers;Biology;Blood;Blood specimen;Canada;Caregivers;Categories;Chinese;Clinical;Clinical Data;clinical predictors;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community advisory board;community collaboration;community engagement;Community Outreach;community partners;Consensus;Data;Data Collection;data management;Data Set;data sharing;Dementia;Diagnosis;Diagnostic;Diet;Disease;DNA;Drug Targeting;effective therapy;Etiology;European ancestry;experience;Family;follow-up;Frequencies;Funding;Future;gene discovery;Genetic;Genetic Diseases;Genetic Research;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;Genotype;geriatric depression;Gold;Health care facility;health disparity;Health Personnel;Hour;Human Genetics;Immigration;improved;Infrastructure;insight;International;Investments;Knowledge;Koreans;Language;Leadership;Life Experience;Life Style;Literature;Long-Term Care;Meta-Analysis;metropolitan;Minority Groups;Modeling;Molecular;multi-ethnic;Neurologic;Neurology;new therapeutic target;non-genetic;outreach;Participant;Pathway interactions;Patients;Persons;Physical activity;Plasma;polygenic risk score;Population;Population Heterogeneity;precision medicine clinical trials;prevent;Procedures;Protocols documentation;quality assurance;Recording of previous events;recruit;reference genome;repository;Research;Research Project Grants;Resources;retention rate;Risk;Risk Factors;risk variant;saliva sample;Sampling;Scientist;screening;sex;SNP array;Socioeconomic Status;Staging;synergism;Training;Translating;Translation Process;United States;Variant;Vietnamese;whole genome

PROJECT_TITLE: Asian Cohort for Alzheimer's Disease (ACAD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: WANG, LI-SAN  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Asian;Asian Americans;Benchmarking;Biological Markers;Budgets;Canada;cohort;Collaborations;Communities;community advisory board;Complex;Consent Forms;Data;data access;Data Analyses;data exchange;data harmonization;data management;Data Set;data sharing;dementia risk;Development;Electronic Mail;Enrollment;Ensure;FAIR principles;Freezing;functional genomics;Funding Agency;Future;Genetic;Genetic Diseases;Genetic study;genome sequencing;genome wide association study;genome-wide;genomic data;Genotype;Human Subject Research;Institutional Review Boards;interest;Leadership;meetings;National Institute on Aging;non-genetic;outreach;Participant;Performance;Persons;Phenotype;phenotypic data;programs;Progress Reports;Protocols documentation;Publications;Qualifying;quality assurance;recruit;Recruitment Activity;Recurrence;repository;Research;Research Personnel;Research Project Grants;Resources;response;Sampling;Schedule;Science;Site;SNP array;Standardization;Structure;symposium;Training;Training Activity;Transfer Agreement;Update;web site;whole genome;Work

PROJECT_TITLE: Core A: Administrative and Enrollment Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PARK, VAN MY TA (contact)

PROJECT_TERMS: Address;Adult;Advocacy;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;animation;Asian;Asian Americans;bilingualism;Biological Markers;brain health;Chinese;cohort;Collaborations;collaborative approach;Collection;Communication;Communities;community advisory board;community based participatory research;community based practice;community partners;Decision Making;Dementia;dementia risk;Directories;diversity and inclusion;Education;Education and Outreach;education resources;Educational Curriculum;Educational Materials;Educational workshop;Effectiveness;English Language;ethnic minority;Ethnic Origin;Event;Family;follow-up;Funding;Genetic;Goals;Health behavior;Health education;Health Fairs;health literacy;improved;Individual;Infrastructure;Intention;Intervention;Koreans;Language;Life Style;Linguistics;Maintenance;Medical;meetings;Methods;Minority Health Research;Monitor;Multicultural Education;Multilingualism;multimodality;older adult;outreach;Pacific Islander;Participant;participant enrollment;participant retention;Policy Maker;Population;Principal Investigator;Professional Organizations;racial minority;Readiness;recruit;Registries;repository;Research;Research Methodology;Research Personnel;Resource Development;Resources;satisfaction;sex;skills;social;social media;sociodemographics;Socioeconomic Status;success;symposium;Theoretical model;tool;Training;Translating;Underrepresented Populations;Vietnamese;virtual;Visit;web site;Writing

PROJECT_TITLE: Core B: B-HEARD Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: HENDERSON, VICTOR  (contact)

PROJECT_TERMS: adjudication;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Asian;Asian Americans;Asian population;Assessment tool;balance testing;bilingualism;Biological Markers;Clinical;Clinical dementia rating scale;Cognition;Cognitive;cohort;Consensus;Cultural Sensitivity;Data;Data Collection;Dementia;dementia risk;design;Diagnosis;Diet;Documentation;Ensure;Evaluation;Exclusion Criteria;experience;Feedback;follow-up;Future;Genetic;genetic analysis;geriatric depression;Goals;improved;innovation;instrument;Life Experience;Life Style;Linguistics;Medical;Medical History;mild cognitive impairment;Neurologic;Neurological observations;Neurologist;non-genetic;older adult;Participant;phrases;Plasma;Population;Procedures;Process;protective factors;Protocols documentation;quality assurance;recruit;Reporting;Research Project Grants;Risk Factors;Site;Stream;Subgroup;Training;waiver

PROJECT_TITLE: Core C: Clinical Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The Molecular Biology Across Scales multidisciplinary training program will train students to tackle biological problems across length scales within and beyond a traditional discipline, thereby enabling high-impact discoveries with ultimate relevance to human health. We will offer a rigorous program focused on broad conceptual knowledge, creative and critical thinking, mastery of experimental logic and methods, application of computational and quantitative approaches, appropriate analysis and interpretation of results, clear and fluent communication of findings, and incorporation of responsible, safe, and ethical practices. MBAS will prepare a highly diverse cadre of young scientists (~30% from historically excluded groups) to join the modern biomedical workforce, meet both present and future scientific and societal challenges, and push the boundaries of knowledge forward.

PI_NAMEs: BILDER, DAVID  (contact);UNAL, ELCIN

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Molecular Biology;Training Programs

PROJECT_TITLE: Molecular Biology Across Scales Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The advent of functional magnetic resonance imaging (fMRI) has revolutionized our understanding of human cognition. Unfortunately, it is nearly impossible to ensure identical execution of fMRI experiments across different MRI scanners due to subtle differences in how MRI scanners from different vendors implement fMRI protocols, leading to challenges in interpretation or pooling results from different fMRI centers. This project will establish and distribute a software environment to help fMRI researchers achieve consistent results across sites and scanner models.

PI_NAMEs: NIELSEN, JON-FREDRIK  (contact);ZAITSEV, MAXIM

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: 3-Dimensional;Active Sites;Adoption;Algorithms;Brain;Brain region;Clinical;Clinical Research;Cognition;cognitive task;Communities;Complex;Computer software;computerized data processing;Data;data acquisition;Data Pooling;data quality;design;Development;Documentation;Education;Ensure;Environment;experimental study;Fatty acid glycerol esters;file format;flexibility;Functional Magnetic Resonance Imaging;Future;Human;Image;image reconstruction;Improve Access;Institution;interest;invention;Knowledge;magnetic field;Magnetic Resonance Imaging;Manufacturer;Maps;Measurement;Methods;Modeling;Motor;Multicenter Studies;Neurosciences Research;open source;open source library;Performance;Physiologic pulse;portability;Procedures;Protocols documentation;Pythons;quality assurance;Quality Control;Reproducibility;Research;Research Personnel;Resources;Rest;Scanning;Signal Transduction;Site;Structure;sustainable resource;Techniques;Technology;Training;Travel;Variant;Vendor

PROJECT_TITLE: A harmonized vendor-agnostic environment for multi-site functional MRI studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: JUN, GYUNGAH  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;analytical method;application programming interface;Asian;Authorization documentation;Biological Markers;central database;Clinical;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communities;computerized data processing;Consultations;Data;data access;data acquisition;Data Analyses;Data Collection;data dictionary;data management;Data Management Resources;data platform;data resource;Data Set;data sharing;data storage site;Database Management Systems;Databases;Dedications;Deposition;design;ethnic diversity;Genetic;genetic analysis;Genetic Diseases;Genetic study;genome-wide;Genotype;Human Resources;Infrastructure;innovation;instrument;Language;Leadership;Life Style;Manuals;Methods;multi-ethnic;National Institute on Aging;non-genetic;Online Systems;outreach;Participant;Phenotype;phenotypic data;Population;Preparation;Protocols documentation;Quality Control;racial diversity;recruit;Reporting;repository;Research Design;Research Personnel;Resources;sample collection;Sampling;Scanning;screening;Secure;Single Nucleotide Polymorphism;Site;SNP array;Statistical Data Interpretation;Statistical Methods;Surveys;System;tool;Training;web interface;web services

PROJECT_TITLE: Core D: Data Management and Analysis Core


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Evaluation and improvement of cancer care quality is of growing interest nationally, with a pressing need for research to support decisions by policy makers, hospital systems, payers, clinicians, and patients – evidenced by the growing scope of the National Cancer Institute’s Division of Cancer Control and Population Science in areas germane to this application, including the programs of Health Care Delivery Research, Health Disparities and Health Equity, Implementation Science, and Survivorship. The UNC Lineberger Comprehensive Cancer Center’s Cancer Care Quality Training Program (CCQTP) is a pre- and postdoctoral fellowship training program that prepares fellows for careers in cancer care quality research, by providing rigorous methodological training with an applied clinical orientation. The CCQTP has successfully trained researchers with a multidisciplinary and collaborative focus over the past 15 years, and proposes to continue its mission to train the next generation of investigators in this field over the next five years.

PI_NAMEs: BASCH, ETHAN M. (contact);WHEELER, STEPHANIE BROOKE

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer care;Quality of Care;Training Programs

PROJECT_TITLE: Cancer Care Quality Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Human Genome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The purpose of this grant is to provide under-represented minority undergraduate students with an opportunity to work on an mentored research project in genome sciences or medicine, supplemented with training in the core genome sciences and ethical/legal/social issues, and to develop essential research skills including conducting a literature review, critical reading of scientific literature, and oral and written presentations. The students supported by this grant will gain the necessary knowledge and experience to continue their educational training in a research-oriented path in science, technology, or mathematics.

PI_NAMEs: HAGA, SUSANNE  (contact);WRAY, GREGORY A.

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: African American;Area;Awareness;Bioinformatics;career;Career Choice;career development;Community Services;Complement;Computational Biology;Country;Data;data access;Data Analyses;Data Science;Data Set;Development Plans;Discipline;education pathway;Education Projects;educational atmosphere;Educational workshop;Engineering;ethical, legal, and social implication;experience;Faculty;faculty mentor;Faculty Workshop;Female;Foundations;genome sciences;Genomic medicine;Goals;graduate student;Grant;Historically Black Colleges and Universities;Individual;Industry;information gathering;Interdisciplinary Study;interest;Interruption;Interview;Knowledge;Laboratories;Learning;Literature;Mathematics;Measures;medical schools;Medicine;Mentors;metabolomics;Modernization;North Carolina;Oral;Paper;Policies;posters;precision medicine;programs;public health relevance;Reading;recruit;Research;Research Project Grants;Review Literature;Schedule;Science;Science, Technology, Engineering and Mathematics;Series;skill acquisition;skills;statistics;STEM field;student mentoring;Students;summer program;summer research;summer student;Surveys;Techniques;Technology;Time;tool;Training;Training and Education;Training Programs;translational genomics;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;Visit;Work;Writing

PROJECT_TITLE: Summer Scholars in Genome Sciences & Medicine


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: YU, HO WH (contact)

PROJECT_TERMS: Address;African American population;Alleles;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid imaging;Asian;Asian population;astrogliosis;biobank;Biological Markers;biomarker development;biomarker performance;Blood;Blood specimen;blood-based biomarker;Brain Diseases;Canada;Cerebrospinal Fluid;Clinical;clinical investigation;Clinical Research;cohort;Cohort Studies;Collection;Communication;Communities;Country;Creatine;Data;Data Analyses;Data Set;Dedications;Detection;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Diet;Disease;Disease Progression;disorder risk;DNA;Early identification;early onset;Elderly;Elements;Ensure;Equipment;ethnic diversity;Ethnic Origin;Etiology;European;European ancestry;Exercise;Foundations;Gene Mutation;Genetic;genetic analysis;genetic risk factor;genetic variant;genome wide association study;Genomics;Glial Fibrillary Acidic Protein;global health;Goals;Heterogeneity;high risk;Hispanic Americans;Image;Individual;Investigation;Knowledge;Late Onset Alzheimer Disease;Life Experience;Life Style;Ligands;Light;Lived experience;Magnetic Resonance Imaging;Manuals;Measures;Modality;Mutation;National Institute on Aging;Nerve Degeneration;neurofilament;neuroinflammation;North America;Participant;Pathologic;Pathology;Pennsylvania;Persons;Plasma;polygenic risk score;population stratification;presenilin;Procedures;Process;Proteins;quality assurance;Race;racial diversity;racial minority;racial population;recruit;repository;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;risk prediction;risk variant;sample collection;Sampling;Serum;Site;Socioeconomic Factors;Spinal Puncture;success;tau Proteins;tau-1;Technology;Therapeutic;tomography;Training;United States;Universities;variant of interest

PROJECT_TITLE: Core E: Biosample Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative The Biophysics Training Program supports a multi-pronged approach to recruiting and training a diverse cadre of predoctoral students and preparing them to become future leaders in biophysics. The program includes core coursework in biophysics at the molecular and cellular levels, quantitative and computational skills development, career development activities, rigorous, reproducible and responsible research, record keeping, and laboratory safety. Students trained in this interdisciplinary program will be uniquely positioned for employment in the biotechnology and pharmaceutical industries and in academic biomedicine, where their discoveries will lead to novel diagnostics and therapeutics for human disease.

PI_NAMEs: HURLEY, JAMES H (contact);YILDIZ, AHMET

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biophysics;Training Programs

PROJECT_TITLE: Biophysics Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Many classes of natural products have tremendous potential as therapeutics or as biological tools but have structural liabilities that limit their utility. Our lab uses modular chemical synthesis with accompanying methodology development to enable systematic modification of promising chemical scaffolds to overcome such liabilities. This proposal outlines several examples of this approach for molecules with anticancer, antibiotic, and antiviral properties.

PI_NAMEs: SEIPLE, IAN BASS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: 2019-nCoV;analog;anti-cancer;Antibiotics;antimicrobial;Area;Bacterial Infections;Binding;Biological;biological systems;Biology;chemical synthesis;Chemicals;Chemistry;Collaborations;Complex;Cryoelectron Microscopy;Data;Derivation procedure;Development;Evaluation;Goals;in vivo;innovation;Investigation;Laboratories;lead optimization;Malignant Neoplasms;Membrane Proteins;method development;Methodology;Methods;Modification;Natural Products;novel;prevent;Property;Protein Isoforms;Research;Research Personnel;resistant strain;Ribosomal Proteins;Roentgen Rays;Route;scaffold;Streptogramins;Structure-Activity Relationship;Therapeutic;tool;Viral;Work

PROJECT_TITLE: Modular synthesis of antibiotic and anticancer classes of natural products


PI_NAMEs: TEE, BOON LEAD  (contact)

PROJECT_TERMS: Adopted;Alzheimer's Disease;American;Asian;Assessment tool;Big Data;Biological Markers;Certification;Chinese;Clinical;Cognitive;cohort;Collaborations;Copyright;Data;Data Analyses;Data Collection;data management;data standards;Educational process of instructing;Educational workshop;efficacy evaluation;Electronics;Ensure;Feedback;Future;health care disparity;Infrastructure;International;Interview;Koreans;Language;Life Style;Manuals;Measures;meetings;member;Minority Groups;Modeling;Monitor;Neuropsychology;outreach;Participant;Periodicals;Population;Population Heterogeneity;Positioning Attribute;Predisposition;prevent;Procedures;Process;programs;Protocols documentation;Publishing;Qualifying;quality assurance;Quality Control;Questionnaires;recruit;Research;response;Risk;Scientist;Site;social health determinants;Standardization;Structure;Surveys;Training;Training and Education;Training Programs;Underrepresented Populations;user-friendly;Video Recording;Vietnamese;web site;Work

PROJECT_TITLE: Core F: Training and Quality Assurance Core


PROJECT_TERMS: African;African ancestry;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Asian;Asian Americans;Asian ancestry;Asian population;Biological Markers;Canada;causal variant;Characteristics;Cognitive;cohort;Collaborations;Collection;Creatine;Data;Data Analyses;data management;Data Set;Disease;East Asian;ethnic difference;European;European ancestry;Frequencies;gene environment interaction;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;genetic profiling;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;Genotype;Glial Fibrillary Acidic Protein;Goals;Heritability;imaging biomarker;Individual;insight;Koreans;Late Onset Alzheimer Disease;Light;Maps;multi-ethnic;neurofilament;North America;novel;Participant;Pathogenicity;Peptides;Performance;Phenotype;Plasma;pleiotropism;polygenic risk score;Population;Positioning Attribute;prevent;Prevention trial;Process;protective allele;Quantitative Trait Loci;Risk;Risk Reduction;risk variant;Sample Size;sex;Subgroup;success;synergism;tau Proteins;tau-1;therapeutic target;treatment trial;Variant

PROJECT_TITLE: Project 1: Genetic Analysis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: YOKOYAMA, JENNIFER S (contact)

PROJECT_TERMS: Acculturation;accurate diagnosis;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Asia;Asian;Asian Americans;Asian ancestry;Asian population;astrogliosis;axon injury;Biological Markers;biomarker development;Blood;Canada;Clinical;clinical diagnosis;clinical trial readiness;Clinical Trials;cognitive function;cohort;Communities;Creatine;Dementia;design;Development;Diagnosis;Diagnostic;Diet;Disease;disease diagnosis;Education;effective therapy;Environment;ethnic minority;Ethnic Population;European;European ancestry;Future;Genetic;Genetic Risk;Glial Fibrillary Acidic Protein;Goals;gray matter;high risk;imaging biomarker;Immigration;Impaired cognition;Individual;Intervention;Intervention Trial;Knowledge;Leisure Activities;Life Style;Light;Link;Measures;Mediating;modifiable risk;Molecular;neglect;neurofilament;neuropathology;non-genetic;North America;novel;Patients;Peripheral;Physical activity;Plasma;Plasma Proteins;polygenic risk score;Population;Population Heterogeneity;Population Study;Positioning Attribute;prevent;Preventive;protective factors;protein biomarkers;Proteins;Psychosocial Stress;racial minority;racial population;Recording of previous events;Reporting;Research;Resources;Risk;Risk Factors;Role;Serum;sex;sex as a biological variable;tau Proteins;tau-1;Testing;Therapeutic Trials;Time;Traction

PROJECT_TITLE: Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic Interactions


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Congenital conditions in which the calvarial suture joints fuse prematurely are common and lead to serious developmental problems, yet the reason why susceptibility to fusion varies among sutures is unclear. This proposal addresses fundamental components that drive regional differences in suture patterning and aims to identify the role for these differences in disease models of premature and delayed suture fusion. These findings will decode cues that impart suture-specific features, which will inform future improvements in patients’ treatments and outcomes.

PI_NAMEs: MERRILL, AMY E (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Affect;Alleles;Anterior;Birth;bone;Brain;Calvaria;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Congenital abnormal Synostosis;Connective Tissue;Connective Tissue Cells;craniofacial;Craniosynostosis;cranium;Cues;Data;Deformity;Development;Developmental Bone Diseases;Disease;disease model;disease-causing mutation;Fibroblast Growth Factor Receptor 2;Fibroblasts;Funding;Future;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;Geometry;Growth;improved;In Situ Hybridization;Infant;joint formation;Joints;Legal patent;Ligaments;Link;loss of function;Mediating;member;Mesoderm;Modeling;Molecular Profiling;Morphology;mouse genetics;mouse model;multiple omics;Mus;Nature;Neural Crest Cell;novel;Nuclear;Pathology;Patients;Pattern;Phenotype;Play;Predisposition;premature;Process;recruit;regional difference;Regulation;Research;Role;Shapes;Signal Pathway;Signal Transduction;single cell genomics;single-cell RNA sequencing;Specific qualifier value;Structure of fontanel of skull;Surgical sutures;suture fusion;Syndrome;Technology;Tendon structure;Testing;TP53 gene;transcriptome sequencing;treatment and outcome;Tretinoin;Variant;WNT Signaling Pathway

PROJECT_TITLE: Fgf signaling in patterning of the calvarial joints

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Trichotillomania and excoriation disorder are disabling psychiatric conditions with limited effective treatments. This research uses a series of complementary neurogenomic investigations to significantly advance our understanding of the genes and neurodevelopmental pathways that contribute to these conditions. This is relevant to public health because it advances our fundamental knowledge of the underlying mechanisms that lead to trichotillomania and excoriation disorder, which has the potential to identify novel treatment targets to ultimately reduce the burden of these conditions.

PI_NAMEs: OLFSON, EMILY HUNT (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Area;autism spectrum disorder;Award;Behavior Therapy;Biological;Biology;Brain;brain cell;Candidate Disease Gene;career;Child;Child Rearing;cohort;comparison control;Copy Number Polymorphism;Data;de novo mutation;Development;differential expression;Disabling;Disease;Distress;DNA Damage;DNA Sequence;DNA sequencing;effective therapy;Ensure;excitatory neuron;Excoriation;exome;exome sequencing;experience;First Degree Relative;Functional impairment;gene network;Genes;Genetic;Genetic Risk;genetic variant;genome-wide;genome-wide analysis;Genomic approach;Genomics;Gilles de la Tourette syndrome;Glutamates;Goals;Hair;Hour;improved;Individual;induced pluripotent stem cell;Inherited;inhibitory neuron;innovation;insight;Intervention;Investigation;Knowledge;medical complication;Mentors;multidisciplinary;Mutation;neural;Neurobiology;neurogenetics;neurogenomics;neuropsychiatry;neurotransmission;novel;Obsessive-Compulsive Disorder;Organoids;Outcome;Parents;Pathway Analysis;Pathway interactions;Patients;Pattern;pharmacologic;Physicians;Population;programs;Public Health;Publishing;Recurrence;repetitive behavior;Research;Research Personnel;Risk;risk variant;Role;Scientist;Series;sex;single-cell RNA sequencing;skills;Skin;success;Synapses;Systems Analysis;Techniques;Testing;Training;transcriptomics;Trichotillomania;Variant;variant detection;Work

PROJECT_TITLE: Neurogenomic Investigations of Trichotillomania and Excoriation Disorder

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: SAN DIEGO

ORG_NAME: ELECTRONIC BIOSCIENCES, INC.

PHR: Project Narrative This program is aimed at developing and validating the individual components and the overall methodology for new nanopore-based technology capable of direct, de novo, single-molecule sequencing of full-length proteins. Rapid, reliable, high-throughput, low-cost, protein sequencing and characterization will enable basic biological research; a more comprehensive assessment of gene expression, protein variations and post translational modifications; and faster disease biomarker discovery and validation, as well as enhanced clinical testing and monitoring of diseases.

PI_NAMEs: PETERSON, ERIC MAYO (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Amino Acids;Back;Biological;biological research;biomarker discovery;biomarker validation;ChIP-seq;Complex;Computer software;cost;data acquisition;Diameter;Disease;DNA;Electronics;Elements;Enzymes;Evaluation;Exclusion;Feasibility Studies;Gene Expression;Goals;high reward;high risk;Homo;improved;Individual;instrumentation;Length;Ligation;Lipid Bilayers;Magnetism;Measurement;Methodology;Methods;Monitor;Motor;nanopore;novel;Nucleic acid sequencing;particle;Peptide Sequence Determination;Peptides;Positioning Attribute;Post-Translational Protein Processing;Preparation;prevent;programs;protein folding;Protein translocation;Proteins;Proteome;Proteomics;prototype;Reader;Reading Frames;research clinical testing;RNA;Sampling;Scheme;Secondary Protein Structure;sequencing platform;single cell proteins;single molecule;Stretching;synthetic peptide;System;Systems Integration;Technology;Time;Variant;voltage

PROJECT_TITLE: Controlled Protein Translocation in Nanopores for Sequencing Applications

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Protective factors across the life course can have profound effects on individual health, including mental health symptoms. Black and transgender women experience intersectional impacts of racism and gender-based discrimination, which may compound adversity and cause symptoms of psychological distress. The proposed study will explore and describe multiple interpersonal protective factors and their association mental health symptoms among Black transgender women, as well as the potential moderating influence of mental health self-management.

PI_NAMEs: KLEPPER, MEREDITH  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Adult;adverse childhood events;Affect;Attitude;barrier to care;Behavior;Birth;Black race;black women;career;Categories;Childhood;cisgender;Communities;community-level factor;Complex;Data Analyses;Data Collection;depressive symptoms;Discrimination;Disease Management;Distress;empowerment;Ethics;experience;Exposure to;Family;functional status;Future;Gender;gender affirmation;gender diverse;Gender Identity;Grant;healing;Health;Health Disparities Research;Health Promotion;improved;Individual;interest;intersectionality;Intervention;Interview;Life Cycle Stages;life span;Major Depressive Disorder;Mental Depression;Mental Health;Mental Health Associations;Methods;Outcome;parenting intervention;Parents;peer;Personal Satisfaction;Persons;physical conditioning;Population;Post-Traumatic Stress Disorders;Prevalence;protective effect;protective factors;Psyche structure;psychological distress;psychological symptom;Quality of life;Race;racial discrimination;racial diversity;racism;Recommendation;Reporting;Research;Research Methodology;Research Personnel;resilience;Respondent;Role;Self Management;Severities;sex;social;Social support;Surveys;symptom self management;Symptoms;theories;Training;transgender;transgender women;United States;Victimization;Woman;Youth

PROJECT_TITLE: Interpersonal Protective Factors and Mental Health Symptom Self-Management Among Black Transgender Women: A Mixed-Methods Study

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(84)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Medications to treat addiction exist for many drugs of abuse, but not for amphetamine-type stimulants, which include amphetamine, methamphetamine and the increasingly popular new psychoactive substances such as synthetic cathinones, also knowns as “bath salts” and “legal highs”. Amphetamine-type stimulants are among the most commonly abused, afflicting approximately 56 million people between the ages of 15 and 64 worldwide, creating a major public health burden, and underscoring a vital need to find effective treatments. Proposed studies will explore a previously unknown mechanism of action of amphetamine-type drugs, with the goal to identify and validate organic cation transporter 3 as a novel target for the development of effective treatments for amphetamine-type stimulant abuse.

PI_NAMEs: DAWS, LYNETTE C (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: addiction;Affinity;Age;Amphetamine Addiction;amphetamine use;Amphetamines;Astrocytes;Attenuated;attenuation;bath salts;Behavior;Behavioral;Brain region;Chronic;Cocaine;Compensation;Complex;conditional knockout;conditioned place preference;Corpus striatum structure;Data;Development;Disease;Dopamine;Dopamine Receptor;dopamine transporter;dopaminergic neuron;Dorsal;Dose;Drug Design;drug of abuse;effective therapy;Elements;Female;Gene Expression;Germ Lines;Goals;Histologic;In Vitro;in vivo;inhibitor;insight;knock-down;Knock-out;Knockout Mice;Knowledge;Legal;Light;Literature;Locomotion;LoxP-flanked allele;male;Measures;Mediating;mephedrone;Methamphetamine;Modeling;Molecular Target;monoamine;Motor Activity;mouse model;Mus;Neuroglia;neurotransmission;nigrostriatal pathway;novel;Nucleus Accumbens;Organic Cation Transporter;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacology;presynaptic;Presynaptic Terminals;prevent;Property;protein expression;psychostimulant;Public Health;response;Rewards;Role;Self Administration;sex;Sex Differences;Signal Transduction;stereotypy;Stimulant;stimulant abuse;stimulant dependence;stimulant use disorder;Substance Use Disorder;synthetic drug;Tamoxifen;Testing;Therapeutic;therapeutic target;Time;Transgenic Mice;treatment strategy;Tyrosine 3-Monooxygenase;uptake;vesicular monoamine transporter;Viral;Wild Type Mouse

PROJECT_TITLE: Uptake2 transporters: Novel sex-dependent molecular targets to treat stimulant use disorder

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The goal of this predoctoral program is to train highly versatile, productive, independent research neuroscientists. To do this, trainees will be equipped with a broad range of skills and knowledge of molecular, cellular, systems, and integrative neuroscience as well as training in translational research, quantitative skills, rigor and reproducibility, career development, cutting edge scientific techniques, mentoring and other issues important to their scientific future.

PI_NAMEs: MAJEWSKA, ANNA K (contact);ROMANSKI, LIZABETH M

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Graduate Training in Neuroscience


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

PHR: Obstructive sleep apnea (OSA) is commonly reported in Veterans with post-traumatic stress disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen nightmares. Continuous positive airway pressure (CPAP) is the most effective therapy but adherence to treatment is suboptimal. Insomnia is considered a barrier to long-term adherence. The overarching theme of the proposal is to compare the effectiveness of cognitive behavioral therapy for insomnia (CBT) plus eszopiclone, a nonbenzodiazepine hypnotic, versus CBT alone in Veterans with PTSD who are diagnosed with both OSA and insomnia, using a randomized, clinical trial, on sleep quality of life, PTSD severity, and CPAP adherence.

PI_NAMEs: EL SOLH, ALI A (contact)

PROJECT_TERMS: actigraphy;Address;Adherence;anxiety symptoms;Area;Awareness;Beck depression inventory;Behavior;Behavior Therapy;Case Management;chronic pain;Clinical;Clinical Trials;cognitive function;Cognitive Therapy;combat;Combined Modality Therapy;Comorbid Insomnia;comorbidity;comparative effectiveness;Comparative Study;compare effectiveness;Complex;Consensus;Continuous Positive Airway Pressure;depressive symptoms;Development;Diagnosis;Disease;Distress;Dreams;Drowsiness;effective therapy;Effectiveness;Eszopiclone;Evaluation;evidence base;Exclusion;experience;Fatigue;follow-up;Guidelines;Health Technology;hypnotic;Impairment;improved;improvement on sleep;indexing;instrument;Investigation;Label;Masks;Measures;Mental Depression;Methods;mHealth;Military Personnel;military veteran;Modality;Modeling;Morbidity - disease rate;Night Terrors;Nightmare;Obstructive Sleep Apnea;Outcome;Pain management;Panic Attack;Participant;Patients;personalized medicine;physical conditioning;Pittsburgh Sleep Quality Index;Placebos;Post-Traumatic Stress Disorders;Primary Insomnia;psychiatric symptom;Psychometrics;Quality of life;Randomized;randomized, clinical trials;Reporting;response;Risk Factors;sedative;Severities;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep Disorders;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;suicide rate;Symptoms;Testing;Therapeutic;therapy adherence;Time;Translating;treatment effect;Treatment Protocols;Veterans;Waiting Lists;Work

PROJECT_TITLE: A pragmatic randomized comparator trial of eszopiclone and brief behavioral therapy for insomnia in CPAP non adherent Veterans with PTSD and complex insomnia


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative The purpose of this training grant renewal, From Biological to Social Processes: Interdisciplinary Training in Life Course Research (ITLCR), is to facilitate the integration of social and health science research approaches to improve the scientific community’s understanding of population health and well-being across the life course. Junior scientists trained in the ITLCR better identify, understand, and produce new knowledge on the social and biological pathways that are important to population health and the understanding of health disparities across the life course. The ITLCR is a demographically diverse training program in which junior scientists work on the cutting edge of the interdisciplinary population sciences while being trained in a context that focuses on the highest standards of research ethics, rigor, and reproducibility.

PI_NAMEs: HUMMER, ROBERT A (contact);THOMPSON, AMANDA L

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Biological;Life Cycle Stages;Research;Social Processes;Training


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE There are 57.7 million people living in the world with limb amputation due to traumatic causes with a 5-year post-amputation survival rate of only 48.6%. Thus, it is important to understand the major limitations behind mammalian composite tissue regeneration in order to develop more effective treatments for those with major wounds such as limb amputations. This project utilizes cutting edge single-cell lineage tracing and gene delivery techniques to investigate the driving forces behind fibrosis and regeneration in the mouse digit tip, a model system that has strong translatability to humans.

PI_NAMEs: JOU, VIVIAN  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Alleles;Amputation;Automobile Driving;Bar Codes;Behavior;Biological Assay;Biological Models;Biological Process;blastema;Candidate Disease Gene;Cell Lineage;cell type;Cells;Cellular Structures;Chromosome Mapping;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;design;differential expression;digit regeneration;Digit structure;Distal;DNA;Doxycycline;driving force;effective therapy;Electroporation;experimental study;Fibroblasts;Fibrosis;Gene Delivery;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetically Engineered Mouse;high throughput screening;Homeostasis;Human;Hydrogels;improved;in vivo;insight;knock-down;Knowledge;limb amputation;Mammals;Modeling;Molecular;Mus;Nail plate;Natural regeneration;overexpression;Persons;Plasmids;Play;Population;Population Dynamics;Population Heterogeneity;Process;Protein Secretion;regenerative;repaired;Research;Resolution;response;Role;Sepharose;single-cell RNA sequencing;small hairpin RNA;Source;Survival Rate;System;Techniques;Testing;tissue regeneration;Tissues;tool;transcriptomics;wound;wound healing

PROJECT_TITLE: Defining key differences in mouse fibroblasts during digit regeneration and fibrosis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This is competitive renewal application for the Brown University Community and Clinical Research Training Program currently funded through NIMH R25MH083620. This structured mentoring program will focus on community-engaged scholarship, geographically circumscribed interventions, reducing racial disparities in HIV infection, and delivering proven HIV prevention and care interventions through novel means in the rural South.

PI_NAMEs: NUNN, AMY STEWART (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Active Learning;Address;Affect;African American;African American population;AIDS prevention;Alabama;Applied Research;Arkansas;Behavioral;Black race;burden of illness;care systems;Caring;Clinical;Clinical Research;Clinical Services;Collaborations;Communities;community engagement;community research;community setting;design;Disparity;Educational Curriculum;Educational workshop;Enrollment;Epidemic;epidemic preparedness;Epidemiology;epidemiology study;ethnic disparity;experience;Faith;Funding;geographic disparity;Geography;Goals;Grant;Health;Health Services Accessibility;Hispanic;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV/AIDS;implementation research;Individual;Institution;Intervention;Investigation;investigator training;Latino Population;Latinx;Latinx population;Lead;men of color;men who have sex with men;Mentors;Mississippi;Missouri;National Institute of Mental Health;Neighborhood Health Center;next generation;novel;novel strategies;Outcome;Peer Review;people of color;Population;pre-exposure prophylaxis;prevention service;programs;racial disparity;Research;Research Personnel;Resource-limited setting;Risk;Rural;Scholarship;Science;screening;screening services;service delivery;Services;social;social factors;Societies;South American;structural determinants;Structure;Technology;therapy design;Training;Training Programs;treatment as prevention;treatment services;underserved community;United States;Universities;uptake;Viral;webinar;Work


ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). Those who have guilt tend to have more severe PTSD and depression symptoms and greater suicide risk. Although PTSD treatments such as Cognitive Processing Therapy (CPT) are effective to treat PTSD and trauma-related guilt, many still experience symptoms or maintain their diagnosis after treatment. Thus, additional and less burdensome approaches are needed. Our work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. In our first study with 144 Veterans who served in conflicts with Iraq or Afghanistan, TrIGR reduced PTSD and depression more than supportive therapy. More than 50% lost their PTSD diagnosis. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like CPT, is the next critical question that this proposed study will seek to answer.

PI_NAMEs: NORMAN, SONYA  (contact)

PROJECT_TERMS: Afghanistan;Aftercare;arm;brief intervention;Clinic;Clinical;Cognitive;cost;depressive symptoms;Diagnosis;Disease;Distress;Dropout;efficacy study;Emotions;Enrollment;evidence base;Exclusion Criteria;experience;Feeling suicidal;Guilt;Healthcare Systems;Impairment;improved;Intervention;Iraq;Learning;Mediating;Mental Depression;Mental Health;Mental Health Services;Outcome;Persons;Phase;Post-Traumatic Stress Disorders;Protocols documentation;Psychopathology;psychosocial;Randomized;randomized, clinical trials;reduce symptoms;Reporting;Resources;response;Role;Severities;Shame;Site;suicidal risk;Supportive care;Survivors;Symptoms;Trauma;trauma exposure;traumatic event;Treatment outcome;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Non-Inferiority Trial of Trauma Informed Guilt Reduction Therapy (TrIGR) for PTSD


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE To advance both a prophylactic HIV-1 vaccine and a functional cure, this Consortium for Innovative HIV/AIDS Vaccine and Cure Research in Non-Human Primates will pursue two main research foci. Research Focus 1 is aimed at optimizing and understanding the mechanism of protection for highly protective vaccine. Research Focus 2 aims to determine whether combining the optimized vaccine concept with latency reversing agents and immune modulators can result in sustained suppression of pathogenic SHIV infection following interruption of high active antiretroviral treatment.

PI_NAMEs: AMARA, RAMA RAO ;HUNTER, ERIC  (contact)

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Address;Adjuvant;Animals;Antibodies;Antibody Formation;Antibody Response;antigen challenge;Antigens;antiretroviral therapy;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;Clinical Research;delivery vehicle;Discipline;Disease remission;Environment;Epigenetic Process;Gene Expression Profile;Goals;Highly Active Antiretroviral Therapy;HIV;HIV envelope protein;HIV resistance;HIV vaccine;HIV-1 vaccine;Immune;Immune response;Immunity;Immunization;Immunomodulators;Individual;Infection;innovation;Interruption;Intravenous;latent HIV reservoir;Macaca;Macaca mulatta;Mediating;Mucosal Immune Responses;Mucous Membrane;neutralizing antibody;nonhuman primate;novel;operation;Pathogenicity;Play;Population;Preventive vaccine;Production;Productivity;programs;prophylactic;Proteins;Refractory;Research;Research Personnel;Resistance;Resources;response;Role;Scheme;Serum;Shock;Signal Transduction;simian human immunodeficiency virus;single cell analysis;SIV;Specificity;Structure of germinal center of lymph node;success;synergism;T cell response;T-Lymphocyte;Techniques;therapeutic vaccine;Tissues;transcriptomics;Vaccinated;Vaccination;Vaccine Design;vaccine efficacy;vaccine response;Vaccine Therapy;Vaccines;vector;vector vaccine;Viral Antigens;viral rebound;Viral reservoir;Viral Vector;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Bacteriophages, viruses that infect bacteria, can defend against emerging pathogens when deployed as targeted antimicrobials or vaccine platforms. However, the human immune response to bacteriophage administration can interfere with efficacy. The proposed research will improve our understanding of bacteriophage immunogenicity and establish novel methods of modulating it to improve phages for biomedical applications.

PI_NAMEs: FREEMAN, KRISTA GABRIELLE (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: adaptive immune response;Adjuvant;Advisory Committees;anti-microbial drug;Antibiotics;Antibodies;Antibody Formation;Antibody Response;Antigen-Presenting Cells;Antigens;antimicrobial;Automobile Driving;B-Lymphocytes;Bacteria;Bacterial Antigens;Bacterial Infections;Bacterial Vaccines;Bacteriophages;Binding;Capsid;career;Clinical;Clinical Trials;combat;Communicable Diseases;Communities;Complex;Cryoelectron Microscopy;Cytotoxic T-Lymphocytes;Data;Data Analyses;Data Collection;Defense Mechanisms;Development;Directed Molecular Evolution;DNA;dosage;Education;emerging pathogen;Engineering;Epitope Mapping;Epitopes;Escape Mutant;experience;experimental study;Foundations;Generations;Grant;Helper-Inducer T-Lymphocyte;Human;Immune Evasion;Immune response;Immune system;Immune Tolerance;Immunocompetent;Immunocompromised Host;immunoengineering;immunogenic;immunogenicity;Immunologics;Immunology;immunoreaction;immunoregulation;Immunosuppressive Agents;improved;in vivo;Infection;Infection prevention;interest;Laboratories;Learning;manufacture;Maps;Medical;Medicine;Mentors;Methods;microbial;Modeling;mouse model;Mus;mutant;Mutate;Mycobacteriophages;Mycobacterium abscessus;Mycobacterium Infections;nanoparticle;Nature;neutralizing antibody;novel;Occupations;Outcome;particle;pathogen;pathogenic bacteria;pathogenic virus;Patients;Phage Display;Pharmaceutical Preparations;Physics;Polymers;Predisposition;Preparation;Price;prophylactic;Publishing;Recombinants;reconstruction;Regulatory T-Lymphocyte;Research;Respiratory Disease;response;Route;Sampling;Serology;Serum;Sirolimus;Site;structural biology;Structure;T cell response;T-Lymphocyte Epitopes;Techniques;Technology;text searching;Therapeutic;thermostability;Training;Vaccination;vaccine candidate;vaccine development;vaccine platform;Vaccines;vector;Virus;Writing

PROJECT_TITLE: Improving phage-based medicine with immunoengineering

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The goal of the proposed program is to support training of advanced graduate students to prepare them for successful and productive careers in neuroscience research that is relevant to translational neuroscience. We anticipate that students so trained will make important future contributions to understanding the causes of, and finding treatments for, disorders of the nervous system.

PI_NAMEs: HENGST, ULRICH  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Behavior;Neurobiology;Training Programs

PROJECT_TITLE: Advanced Graduate Training Program in Neurobiology & Behavior