ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Sjögren’s syndrome (SS) is a complex autoimmune disorder, affects 2-3.1 million Americans, involves dysfunction of moisture-producing glands that is mediated by immune responses, and can result in irreversible tissue damage and serious complications such as neurological problems, lung disease and cancer. This project involves a large international group of SS experts collaborating to identify and characterize genetic risk factors that alter the function of various cell types in salivary glands and the immune system. This new knowledge is critical for identifying effective ways to subset patients based on different causes of SS, developing better clinical tools to diagnose patients earlier before tissue damage occurs, identifying patients at high risk for lymphoma and other poor outcomes, and helping to establish the feasibility of novel candidate therapies and repurposing existing drugs that may be effective in SS but have not yet been considered for clinical trials. !

PI_NAMEs: LESSARD, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: accurate diagnostics;Acinar Cell;Affect;American;Antigen Presentation;Autoantibodies;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Bioinformatics;Biological Markers;Biological Products;Biological Response Modifier Therapy;Biological Response Modifiers;biomarker identification;Biopsy;Blood Banks;causal variant;Cell Physiology;cell type;Cells;Classification;Clinical;Clinical Data;clinical translation;Clinical Trials;cohort;Collaborations;Complex;Coupled;cytokine;Data;Dedications;Dendritic Cells;Development;Diagnosis;diagnostic tool;Dimensions;Disease;disease heterogeneity;disease model;Dryness;Duct (organ) structure;Ductal Epithelial Cell;Epithelial Cells;European;Exhibits;Exocrine Glands;falls;Fatigue;Feedback;Fostering;Functional disorder;gene discovery;Gene Expression;Genes;Genetic;genetic architecture;genetic association;Genetic Determinism;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;genome wide association study;Genomic Segment;Gland;Goals;Hematologic Neoplasms;high risk;Histologic;IL12A gene;Immune;Immune response;Immune system;innovation;insight;Interferon Type I;Interferon Type II;Interleukin-12;International;Knowledge;Laboratories;Lacrimal gland structure;Lesion;Life;Link;Lung;Lung Diseases;lymphocyte trafficking;Lymphoma;Malignant neoplasm of lung;Maps;Mediating;Mediator;Methodology;Minor;Modeling;Molecular;molecular marker;monocyte;Morphology;Natural Killer Cells;Neurologic;Neuropathy;new therapeutic target;NF-kappa B;novel;Organ;Outcome;overexpression;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathology;Pathway interactions;patient biomarkers;Patient Care;patient stratification;patient subsets;Patients;Pattern;Peripheral;peripheral blood;Pharmaceutical Preparations;phenotypic data;Population;PRDM1 gene;Production;Proteomics;Publishing;Quantitative Trait Loci;Research;Resolution;response;Ribonucleoproteins;Risk;Risk Factors;risk variant;Role;Salivary Gland Tissue;Salivary Glands;Sample Size;Sampling;Signal Transduction;Sjogren's Syndrome;Specificity;STAT4 gene;Stratification;Study Subject;Surrogate Markers;T-Lymphocyte;targeted treatment;Technology;Testing;therapeutic target;Time;Tissue Banks;Tissues;tool;transcriptomics;TYK2;Variant;Work

PROJECT_TITLE: Discovery and Characterization of Genetic Risk Loci in Sjogren's Syndrome

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  Tyrosine Kinase Inhibitors (TKIs) can be life-saving therapies for many patients suffering from cancer. Unfortunately untoward cardiovascular side-effects are common and can lead to cessation of a life-saving therapy. This proposal is motivated by our hypothesis that TKI-induced arrhythmia acts in part through oxidative activation of CaMKII and increased INa,L in cardiac myocytes leading to cardiac excitability.

PI_NAMEs: SMITH, SAKIMA AHMAD (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Action Potentials;Animal Model;Animals;anti-cancer treatment;Apoptosis;Arrhythmia;Calmodulin;Cancer Survivor;Cardiac;Cardiac Myocytes;cardioprotection;Cardiotonic Agents;Cardiotoxicity;Cardiovascular system;Cause of Death;Cells;Cessation of life;clinical decision-making;Data;Defect;Dimethyl Sulfoxide;Drug usage;Elderly;Electrocardiogram;Electrophysiology (science);Event;experimental study;FDA approved;Fibrosis;Functional disorder;Genes;Glucose;Growth;Heart;Heart failure;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Incidence;induced pluripotent stem cell;inhibitor;inhibitor therapy;innovation;Ion Channel;Ions;Isoproterenol;Lead;Life;Malignant Neoplasms;Maps;Marketing;Mitochondria;Molecular;Morbidity - disease rate;mortality;Mus;Muscle Cells;Myocardial dysfunction;novel;Optics;Organ;oxidation;Pathogenicity;Pathologic;Pathway interactions;Patient Agents;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Population;Prevalence;prevent;Production;Proteins;Reactive Oxygen Species;Renal Carcinoma;Renal Cell Carcinoma;Role;side effect;Signal Pathway;Signal Transduction;Sodium;Stress;success;symporter;Testing;Therapeutic;Time;Transcript;Transgenic Mice;Translating;Treatment Efficacy;Treatment-Related Cancer;Tyrosine Kinase Inhibitor;Ventricular;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Defining Novel Cardiovascular Mechanisms For TKI Induced Excitability

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE – University of Colorado Denver This proposal for the University of Colorado Denver/Children’s Hospital Colorado Pediatric Critical Care  Program and our ancillary site, Arkansas Children’s Hospital, to participate in the CPCCRN describes our  institutions’ commitment to pediatric critical care research and training junior investigators as well as the  extensive capabilities, experience, investigations, and patient population which we will contribute to the  network. Our institutions represent large geographically unique and diverse populations of children, which will ensure CPCCRN studies embody the diversity of our nation and the findings are generalizable to all critically ill  and injured children.

PI_NAMEs: NOZIK, EVA S. (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Address;Admission activity;alveolar epithelium;Area;Arkansas;Award;Basic Science;Blood Vessels;carbohydrate metabolism;Cardiopulmonary;Cardiovascular Diseases;career development;Caring;Catchment Area;Child;Child Development;Child Health;Childhood;Childhood Injury;Clinical;Clinical and Translational Science Awards;Clinical Research;clinical research site;Clinical Sciences;clinical translation;Clinical Trials;cohort;Collaborations;Colorado;Complement Activation;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Development;Discipline;Disease;effective therapy;Ensure;Ethnic Origin;Evaluation;expectation;experience;Faculty;Family;follow-up;Functional disorder;Funding;Geography;Goals;Good Clinical Practice;Hospitalization;Immune response;immunoregulation;improved outcome;innovation;Institution;Investigation;Knowledge;Laboratories;Leadership;Link;Location;Longitudinal Studies;Lower Respiratory Tract Infection;Lung;Lung Diseases;medically underserved;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Metadata;Mission;Mississippi;Molecular;multidisciplinary;Multiple Organ Failure;National Heart, Lung, and Blood Institute;next generation;Organ;Outcome;Outpatients;outreach program;Participant;participant enrollment;pathogen;Pathogenesis;patient population;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;pediatric department;Pediatric Hospitals;Performance;personalized therapeutic;Physicians;Population;Population Heterogeneity;Principal Investigator;Procedures;Process;Program Development;programs;Protocols documentation;Publications;pulmonary vascular disorder;Race;Recording of previous events;Rehabilitation therapy;Research;Research Design;Research Institute;Research Personnel;Research Priority;Research Training;Resources;Respiratory Failure;respiratory microbiome;Role;Rural;Scientific Advances and Accomplishments;Scientist;Sepsis;Series;severe injury;Site;socioeconomics;success;Talents;Technology;Training;Training Programs;Translational Research;Translational trial;Translations;Traumatic Brain Injury;underserved community;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The proposed research will combine olfactory psychophysics, behavioral tasks, neuroimaging, and non- invasive brain stimulation to examine neural principles of olfactory reward in the human brain. The proposed studies will be important for revealing neural correlates and the causal contributions of brain networks to learning and decision making involving food odors. The expected findings may have clinical relevance for neuropsychiatric diseases that are characterized by impaired learning and decision making.

PI_NAMEs: ZELANO, CHRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: addiction;Address;Animal Behavior;Animals;Anterior;Architecture;Behavior;Behavioral;Brain;Central Nervous System;clinically relevant;Complex;Cues;Data;Decision Making;Desire for food;Detection;Development;diagnostic biomarker;Disparate;Dissociation;Dopamine;Eating;Eating Disorders;Environment;Event;expectation;experimental study;field study;Food;Food Processing;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Human;Hunger;Image;Impairment;Individual;innovation;insight;knowledge translation;Lateral;Learning;Mate Selections;Memory;Methods;Midbrain structure;Modality;Modeling;Motivation;Network-based;neural;neural correlate;neuroimaging;neuromechanism;Neurons;neuropsychiatric disorder;neuropsychiatry;noninvasive brain stimulation;novel;novel diagnostics;novel therapeutic intervention;Odors;Olfactory Cortex;Outcome;Pattern;Perception;piriform cortex;Play;Positioning Attribute;Property;Protocols documentation;Psychological reinforcement;Psychometrics;Psychophysics;reinforcer;Research;response;reward processing;Rewards;Role;Satiation;Schizophrenia;Sensory;Signal Transduction;Site;Sleep Deprivation;Smell Perception;Strawberries;Techniques;Testing;theories;Time;Transcranial magnetic stimulation;Update;Work

PROJECT_TITLE: Principles of olfactory reward processing in the human brain


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Narrative Kidney repair is a key determinant of the outcome or prognosis of AKI survivors. This project will investigate DNA methylation in kidney repair after AKI. The work will gain significant new insights into kidney repair and identify novel therapeutic strategies to improve kidney repair and the prognosis of AKI survivors.

PI_NAMEs: DONG, ZHENG  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Basic Science;Biological Assay;Chronic;Chronic Kidney Failure;Cisplatin;Data;Deoxycytidine;Development;Disease;DNA Methylation;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNMT3a;Down-Regulation;Epigenetic Process;epigenetic regulation;Fibrosis;Gene Expression;gene repression;Genes;Health;Homeobox;Hypermethylation;improved;In Vitro;in vivo Model;Inflammation;Injury to Kidney;insight;interstitial;Ischemia;Kidney;Kidney Diseases;kidney fibrosis;kidney repair;Knockout Mice;Mediating;MicroRNAs;Modeling;mortality;mouse model;Mus;novel therapeutic intervention;Outcome;Pathology;Patients;pharmacologic;Play;Positioning Attribute;Prevalence;Profibrotic signal;Prognosis;promoter;Proximal Kidney Tubules;Renal function;renal ischemia;Renal tubule structure;repaired;Reperfusion Injury;Reporting;Repression;Research;Risk Factors;Role;Signal Transduction;Structure;Survivors;Testing;Therapeutic;Tubular formation;Ureteral obstruction;Work

PROJECT_TITLE: DNA methylation in kidney repair after ischemic AKI

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Older adults (age ≥ 60 years) do not tend to engage in the recommended levels of physical activity and are less active than younger adults. This lack of PA is associated with increased risk of all-cause mortality. This proposal seeks to optimize the Fit and Strong! program, or a physical activity intervention for older adults, by creating an adjunct, online platform that is capable of syncing with wearable devices (e.g., fitbit). We will examine the feasibility, acceptability and explore the efficacy and sustainability of this adjunct, online platform in churches and senior centers. This project addresses the critical need of enhancing physical activity in older adults and could have a substantial public health benefit if gains are maintained through the follow-up phase.

PI_NAMEs: SYLVIA, LOUISA  (contact);VRANCEANU, ANA-MARIA

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adult;Advocacy;Age;Black church;Black Populations;Black race;Boston;Bypass;Chronic Disease;Church;Communities;cost;Development;Education;Endowment;ethnic diversity;evidence base;Exercise;exercise intervention;experience;Exploratory/Developmental Grant;Feasibility Studies;Feedback;fitbit;Focus Groups;follow-up;Funding;Health;Health Benefit;improved;instructor;Intervention;Interview;Measures;Modeling;moderate-to-vigorous physical activity;mortality;National Institute on Aging;older adult;Older Population;Outcome;Participant;peer;Persons;Phase;Physical activity;physical inactivity;Pilot Projects;pilot trial;Policies;Population;Population Study;Program Accessibility;programs;Public Health;Randomized;Recommendation;Reduce health disparities;Research;Research Support;Risk;satisfaction;Schedule;Structure;Training;trend;wearable device;young adult

PROJECT_TITLE: Healthy Activity Improves Lives (HAIL)

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed research is relevant to public health because it is focused on identifying how TRIM29 promotes bladder cancer invasive progression and metastasis. This information is likely to identify biomarkers which may allow early detection of invasive/metastatic potential and novel therapeutic targets, both areas of unmet need in the bladder cancer field. This proposal is directly responsive to the NCI mission and specifically responsive to FOA: PAR-19-183 Biology of Bladder Cancer, which identifies “Mechanistic understanding of bladder cancer invasion and metastasis,” and “Developing and validating new human relevant models of bladder cancer” as key areas of interest.

PI_NAMEs: PALMBOS, PHILLIP L (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Animal Model;Area;Automobile Driving;beta catenin;Binding;Biological Assay;Biology;biomarker identification;Bladder Neoplasm;cancer initiation;cancer invasiveness;Cancer Model;Cells;Clinical;Complex;Development;Diagnosis;Disease;DNA Repair;Early Diagnosis;Early identification;Event;Focal Adhesions;Gene Modified;Goals;high risk;Human;human disease;Immune;improved;in vivo;inhibitor;innate immune pathways;innovation;insight;interest;Intermediate Filaments;Invaded;Keratin;Knowledge;live cell imaging;Local Therapy;Malignant neoplasm of urinary bladder;Mediating;MicroRNAs;Mission;Modeling;Molecular;Molecular Conformation;Molecular Target;mortality;mouse model;Muscle;muscle invasive bladder cancer;Mutation;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;paxillin;Persons;Pharmaceutical Preparations;prevent;Prevention;Process;progression risk;Proteins;PTK2 gene;Public Health;Regulation;Relapse;Research;Risk;Role;scaffold;Signal Transduction;SRC gene;Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;three-dimensional modeling;TRIM Motif;tumor;Tumor Cell Invasion;tumor initiation;tumor progression;Tumor Promotion;ubiquitin ligase;Ubiquitination;United States

PROJECT_TITLE: Mechanism and Therapeutic Targeting of TRIM29-mediated Invasion in Bladder Cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PHR: Project Narrative  The ability of HIV to escape from sub-optimal dosing of existing antiretroviral drugs and avoid neutralization by the immune system are two of the greatest challenges facing the development of effective strategies to control and eliminate infection. This proposal seeks to develop a novel class of drugs that can both neutralize HIV while simultaneously reducing the activity of addictive substances. Using this approach, we seek to create functional cure of HIV infection and substance use disorder with a single product administration.

PI_NAMEs: BALAZS, ALEJANDRO BENJAMIN (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Animal Model;Anti-Retroviral Agents;Antibodies;Biological Assay;Cells;Communicable Diseases;design;Development;Doctor of Philosophy;Dose;Engineering;Escape Mutant;experimental study;Gene Transfer;Grant;Health;HIV;HIV Infections;HIV-1;Immune response;Immune system;immunoengineering;Immunotherapy;improved;in vivo;Individual;Infection;Laboratories;medical schools;Mission;Modeling;Mus;National Institute of Drug Abuse;nonhuman primate;novel;novel drug class;Outcome;Persons;Pharmaceutical Preparations;polyclonal antibody;Principal Investigator;professor;Regimen;Research;Series;Substance Use Disorder;Technology;Testing;Therapeutic Intervention;United States National Institutes of Health;vector;Virus

PROJECT_TITLE: Polyclonal Bi-Specific Vectored ImmunoTherapy to Functionally Cure HIV Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-X (J1)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project narrative (3 sentences) Brain-body communication is crucial for maintaining tissue homeostasis and overall health. Studying how aging affects brain-body communication is important for finding ways to prevent age-related diseases and promote healthy aging. We aim to develop an interdisciplinary platform to unravel the intricate aging trajectories within the complex organism to uncover age-related changes in brain-body communication and develop personalized aging interventions.

PI_NAMEs: LI, HONGJIE  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Affect;Age;age related;age related changes;age-related disease;Aging;Biological Models;Blood Vessels;Brain;brain dysfunction;Cells;Communication;Complex;Comprehension;Deterioration;Health;healthy aging;Homeostasis;Hormones;Immune;Impaired cognition;Individual;innovation;interdisciplinary approach;Intervention;machine learning method;Nerve;Neurons;Organism;personalized intervention;prevent;Process;Resolution;Rest;sequencing platform;Signal Transduction;single cell sequencing;Tissues;tool;Whole Organism

PROJECT_TITLE: Systematic Brain-Body Communication and Personalized Aging Trajectories

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-A (70)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Plant nectar-feeding is essential for survival and reproduction for many mosquito species, and mosquitoes locate sugar sources by using their sensitive olfactory system. Trap-and-kill systems that exploit the nectar-feeding behaviors have shown to be an effective control intervention, but we don't know which odorants in the plant scent that mosquitoes find attractive, or how they process this information in their olfactory system. Using Aedes aegypti mosquitoes, we will characterize the genes involved in the odorant reception of nectar source odors and determine the mechanisms by which this olfactory input is processed in the brain, thereby providing new attractant lures and tools for mosquito control.

PI_NAMEs: AKBARI, OMAR SULTAN;PITTS, RONALD JASON;RIFFELL, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Aedes;Affect;Anopheles Genus;Arboviruses;base;Behavior;behavior test;Behavioral;Behavioral Assay;Biological Assay;Blood;Brain;Calcium;Chemicals;comparative;contrast enhanced;CRISPR/Cas technology;Culex (Genus);Culicidae;Data;Detection;Development;Discrimination;Disease;Drosophila genus;Effectiveness;Environment;experimental study;feeding;Feeding behaviors;Female;Flowers;Flying body movement;Fruit;gamma-Aminobutyric Acid;Gas Chromatography;Gene Targeting;Genes;genetic approach;genome editing;Goals;Image;Immune response;Insect Vectors;Insecticides;insight;Intervention;life span;Ligands;Link;Lobe;male;Mediating;Methods;Modeling;Mosquito Control;mutant;mutualism;neural;Neurons;Nutrient;Odorant Receptors;Odors;Olfactory Pathways;Olfactory Receptor Neurons;Oocytes;Orphan;Outcome;Pathway interactions;Peripheral;Persons;Physiological Processes;Plants;Play;Population;Process;programs;Publishing;Rapid screening;Reproduction;response;Role;Shapes;Smell Perception;Source;sugar;Surveys;System;Technology;Testing;tool;Variant;vector management strategies;Vectorial capacity;Volatilization;Work

PROJECT_TITLE: The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Aging;Genetics

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Age reversal in an entire organism can postpone age-related diseases and enhance the well-being during the later stages of life. Our research has revealed that sexual planarians of Schmidtea mediterranea have evolved a natural solution to age reversal at the whole-body level, and here we propose to investigate the underlying molecular and cellular mechanisms that drive age reversal. Successful completion of the project holds the promise of providing valuable insights to advance anti-aging medicine for humans.

PI_NAMEs: GUO, LONGHUA  (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Age;Age Distribution;age effect;age-related disease;aged;anti aging drug;Back;Biological Clocks;cell age;Cell Differentiation process;Cell Physiology;Cells;Chromatin;Epigenetic Process;experimental study;Gene Expression;Genes;Goals;Homeostasis;Human;human old age (65+);improved;insight;Life;Mammals;Molecular;Natural regeneration;Organism;Personal Satisfaction;Planarians;Play;Process;Quality of life;Reporting;Research;Role;stem cell division;Tissues;Whole Organism

PROJECT_TITLE: Turning back biological clock: mechanisms of age reversal in a whole organism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-L (70)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Pediatric;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE. Benzodiazepines are frequently prescribed to adolescents and young adults, yet we lack key data on misuse, abuse, and overdose risk following benzodiazepine treatment and on what policies reduce benzodiazepine- related harms in young people. The proposed research will examine the risk of overdose and harmful substance use following benzodiazepine treatment and will evaluate whether state prescription drug monitoring program features are associated with a reduction in benzodiazepine-related harms and risky benzodiazepine prescribing. As more young people seek treatment for mental illness, it is of urgent public health importance to investigate the misuse and abuse potential of commonly prescribed pharmaceutical treatments and to consider modifiable factors, such as existing prescription drug monitoring programs, that can be leveraged to reduce harms.

PI_NAMEs: BUSHNELL, GRETA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: abuse liability;Address;Adolescent;Adolescent and Young Adult;Adolescent Development;Adult;Age;age group;Alternative Medicine;alternative treatment;Anxiety;Area;Award;benzodiazepine abuse;benzodiazepine misuse;Benzodiazepines;career;Cessation of life;Community Practice;Coping Skills;Data;Data Set;Databases;Dependence;Detection;Development;Disease;Dose;Drug abuse;Drug Prescriptions;Early Intervention;Electronics;Emergency department visit;emerging adult;Evaluation;experience;Future;Harm Reduction;Health Resources;Heterogeneity;improved;Individual;innovation;Intervention;Knowledge;Life;Measures;Medicaid;Medical;Medicine;Mental Depression;Mental disorders;Mentored Research Scientist Development Award;Methodology;Methods;misuse of prescription only drugs;Monitor;Morbidity - disease rate;Opioid;opioid epidemic;opioid use;Outcome;Overdose;overdose death;overdose risk;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Policies;prescription monitoring program;prescription opioid;prevent;Privatization;programs;Provider;Public Health;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;risk stratification;Running;Safety;Sampling;sedative;Sleep Disorders;Substance abuse problem;substance misuse;substance use;Surveys;System;Time;Training;Training Programs;Tranquilizing Agents;treatment risk;twelfth grade;young adult;Youth

PROJECT_TITLE: Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribing


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Nearly all adolescents use social media sites, yet for a vulnerable subset of teens, social media use may increase risk for suicide. Given rising suicide rates among adolescents in recent years, it is critical to examine the reasons why social media use may be related to suicidal thoughts and attempts. Findings of this study will have the potential to inform future suicide intervention and prevention efforts that address the unique needs of adolescents in the digital age.

PI_NAMEs: NESI, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Administrative Supplement;Adolescent;Adolescent Development;Affect;Affective;Age;Area;Arousal;Attention;Behavioral Mechanisms;Benefits and Risks;career;career development;Clinical;Clinical Research;Cognitive;Data;Data Set;Databases;Dedications;Development;digital;Discipline;Disease;Emotional;Ensure;Environment;Ethics;Exhibits;experience;Eye;Facebook;Feedback;Feeling suicidal;follow-up;Fostering;Frequencies;Future;gaze;Goals;Hospitals;Image;indexing;Individual;innovation;Instagram;interdisciplinary collaboration;Intervention;Interview;Laboratories;Length;Linguistics;Literature;Longitudinal Studies;Machine Learning;machine learning classifier;machine learning method;machine learning model;Measures;media use;Mental Health;Mentors;Metadata;Methods;Modeling;National Institute of Mental Health;Natural Language Processing;Participant;Patient Self-Report;peer;Persons;Phase;Physiological;Positioning Attribute;Predisposition;prevent;programs;prospective;Psychiatry;Published Comment;Questionnaires;Recording of previous events;recruit;Research;Research Personnel;Resources;response;Rhode Island;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Self Disclosure;Series;Severities;Site;social;Social Environment;social media;social norm;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Techniques;Teenagers;Testing;therapy development;Time;Training;Translational Research;Universities;Visit;visual tracking;Work;Youth

PROJECT_TITLE: Administrative Supplement: Social Media Use and Mechanisms of Suicide Risk in Adolescents


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative When a taste is placed on our tongues, we must recognize that a taste is on the tongue, identify that taste, decide whether it’s palatable or not, and then either swallow it or expel it. This thought process can be observed to play out in the firing of neurons in taste cortex, but evidence suggests that cortex doesn’t work alone. We will rigorously test how the amygdala (the seat of emotion in the brain) and hypothalamus (the center that controls hunger and thirst) work with cortex, and with one another, to make taste decisions happen, and how these decisions get implemented by motor circuits—adding to a systemic understanding of taste that will help us fight against a spectrum of feeding-related disorders.

PI_NAMEs: KATZ, DONALD B (contact)

PROJECT_TERMS: Amygdaloid structure;Back;Biological;Brain;brain circuitry;Cells;Code;Complex;Decision Making;Deglutition;Disease;Eating;Emotions;feeding;fighting;Food;Hunger;Hypothalamic structure;insight;Motor;neural;Neurons;novel;Oral cavity;Perception;Play;Process;Rattus;Reporting;Research Project Grants;Role;Sampling;sugar;sweet taste perception;System;Taste Perception;taste system;Testing;Thinking;Thirst;Tongue;Work

PROJECT_TITLE: Temporal Coding and Palatability in Gustatory Cortex


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE For more than 20 years we have studied the impact of cocaine use in African American people living with HIV (PLWH); from which two important findings are (1) cocaine accelerates coronary disease (CAD), and (2) a contingency management (CM) intervention reduces cocaine use and slows, even reverses CAD progression in PLWH. We now propose to study the impact of reduced cocaine use using this CM intervention on cognitive decline and associated structural and functional brain MRI measures in this high-risk population.

PI_NAMEs: LAI, SHENGHAN  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Acceleration;Address;Adult;Adverse effects;Affect;African American;African American population;Age Years;aged;Aging;AIDS dementia;Alzheimer's Disease;antiretroviral therapy;Appearance;arterial spin labeling;Biological Markers;biomarker performance;Brain;brain magnetic resonance imaging;Cardiovascular system;Cocaine;Cocaine Dependence;cocaine use;Cocaine Users;Cognition;Cognitive;cognitive change;cognitive performance;cognitive testing;comorbidity;contingency management;Coronary heart disease;coronary plaque;Coronary Stenosis;Data;Dementia;Diffusion Magnetic Resonance Imaging;Disease Progression;early detection biomarkers;Early Diagnosis;Education;Effectiveness;FDA approved;follow-up;Functional Magnetic Resonance Imaging;Health Benefit;health disparity;Heart Diseases;High Prevalence;high risk population;Hippocampus;HIV;HIV-associated neurocognitive disorder;Impaired cognition;improved;Incentives;Incidence;Income;Individual;instrument;Intervention;Investigation;Length;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;men;Monitor;MRI Scans;multidisciplinary;Neurobehavioral Manifestations;Neurocognitive Deficit;neuroimaging;neuropathology;Neuropsychological Tests;Outcome;Participant;Persons;Pharmaceutical Preparations;Population;radiomics;recruit;Research;Rest;Risk;Risk Factors;Severities;Structure;Symptoms;United States National Institutes of Health;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: Cocaine Abstinence or Reduced Use May Retard Alterations in Brain Structure and Function, and Associated Cognitive Changes among African American Cocaine Users with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (J2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Co-occurring substance use and HIV risk among people in carceral settings is a syndemic. Yet, gold standard interventions to stem adverse OUD outcomes and prevent HIV infection (e.g., pre-exposure prophylaxis, PrEP; and medications for opioid use disorder, MOUD, e.g., buprenorphine) have been underemployed in carceral and community re-entry settings. Therefore, we propose conducting a hybrid implementation-effectiveness type 2 study to optimize and test the efficacy of a long-acting injectable PrEP + buprenorphine (XR-B) co-located intervention in jail and prison settings located in Ending the Epidemic Sites in Maryland and Washington, DC.

PI_NAMEs: BECKWITH, CURT G;BRINKLEY-RUBINSTEIN, LAUREN  (contact);GORDON, MICHAEL SCOTT

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Adherence;adherence rate;Adult;AIDS prevention;Buprenorphine;buprenorphine treatment;Clinical;Collaborations;Common Data Element;Communities;community partners;community reentry;compare effectiveness;Complex;Consolidated Framework for Implementation Research;County;Data;Dropout;Education;effectiveness/implementation hybrid;effectiveness/implementation trial;efficacious intervention;efficacy testing;Eligibility Determination;Epidemic;experience;FDA approved;follow-up;Formulation;General Population;Goals;health care settings;high risk population;HIV;HIV Infections;HIV risk;HIV Seropositivity;housing instability;Hybrids;implementation barriers;implementation evaluation;implementation facilitation;implementation outcomes;Imprisonment;improved;improved outcome;Injectable;innovation;Institutional Review Boards;Intervention;Interview;Jail;Maintenance;Maryland;medication for opioid use disorder;opioid use disorder;Oral;Outcome;Participant;Persons;Pharmaceutical Preparations;Phase;Population;pre-exposure prophylaxis;Prevalence;prevent;primary outcome;Prisons;Procedures;prospective;Protocols documentation;Qualitative Research;Randomized;recruit;Research;Research Personnel;Risk Behaviors;Safety;Screening procedure;Services;Site;social;stem;substance use;Surveys;syndemic;Time;trial enrollment;Underemployment;uptake;Visit;Washington;Work

PROJECT_TITLE: NOTRE: optimizing long-acting pre-exposure prophylaxis and medications for opioid use disorder interventions in carceral settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 GXM-E (J1)]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE (Overall: Human Pangenome Coordination Center) We will extend the successful infrastructure developed by the Human Pangenome Reference Consortium Coordination Center. Our team has extensive experience in managing large interdisciplinary research efforts, creating high-value community resources, running outreach activities including workshops, and managing NIH- funded consortia. We will coordinate among consortium elements, construct and validate pangenome representations, develop and support a pangenome tool ecosystem, engage user communities, and build the international Human Pangenome Project.

PI_NAMEs: HALL, IRA M;LI, HENG ;MARTIN, FERGAL JAMES;PATEN, BENEDICT ;WANG, TING  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Acceleration;Address;Adoption;Archives;Attention;Basic Science;Biomedical Research;Clinical;clinical application;Collaborations;Collection;Communication;Communities;community engagement;Community Health;Computing Methodologies;Consensus;Consent;Data;Data Reporting;Democracy;Development;Diploidy;Disease;Disparate;Documentation;E-learning;Ecosystem;Educational workshop;Elements;Ensure;ethical, legal, and social implication;Ethics;experience;Feedback;flexibility;Fostering;Foundations;Funding;Future;Generations;Genes;genetic resource;Genetic Variation;Genome;genomic variation;Genomics;global health;Goals;Graph;Haplotypes;Human;Human Genetics;human genomics;human pangenome;human reference genome;improved;indexing;informatics tool;Infrastructure;innovation;Interdisciplinary Study;International;international partnership;Libraries;Medical Genetics;Mission;National Human Genome Research Institute;outreach;pan-genome;Participant;Phase;Population;precision medicine;recruit;reference genome;Research;Research Design;Resources;Running;Sampling;Sister;Technology;telomere;tool;Training and Education;United States National Institutes of Health;usability;user-friendly;web site;webinar;Work;working group

PROJECT_TITLE: The Human Pangenome Reference Consortium Coordination Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J2)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: WANG, TING  (contact)

PROJECT_TERMS: Adopted;Adoption;bioinformatics tool;cohort;Collaborations;Communities;community engagement;Consent;Data;data access;Data Reporting;Data Storage and Retrieval;Democracy;Economics;Ecosystem;Elements;Ensure;Environment;Equity;ethical, legal, and social implication;experience;Feedback;flexibility;Fostering;Foundations;Generations;Genes;Genome;genomic data;Genomics;Graph;Haplotypes;Human;Human Genome;human pangenome;human reference genome;Humanities;improved;indexing;Individual;informatics tool;International;Libraries;Methods;pan-genome;Participant;Phase;Population;Process;Publications;Publishing;reference genome;Research Personnel;Resources;Sampling;Science;Sister;Solid;Strategic Planning;Structure;success;System;Technology Transfer;telomere;tool;Update;Work

PROJECT_TITLE: Human Pangenome Reference


NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PROJECT_TERMS: Address;Adopted;Adoption;Basic Science;Benchmarking;Clinical;Clinical Research;Code;Collaborations;Communication;Communities;community engagement;Community Outreach;Complement;Consent Forms;Data;Data Analyses;data dissemination;data exchange;data quality;data sharing;Data Storage and Retrieval;data submission;Democracy;design;Development;Disease;Documentation;Ecosystem;Education;education resources;Ensure;Equity;equity, diversity, and inclusion;ethical, legal, and social implication;Ethics;Feedback;Fostering;functional genomics;Future;genetic counselor;Genetic study;Genomics;global health;Graph;Haplotypes;Health;health disparity;Human;human pangenome;Infrastructure;International;international partnership;interoperability;Justice;Knowledge;Language;Laws;Medical;meetings;member;Methods;Molecular;Molecular Diagnosis;Ontology;outreach;Ownership;pan-genome;Pathway interactions;Phase;Policies;Population;portability;programs;Protocols documentation;public database;quality assurance;Readability;recruit;Research Personnel;Resources;sample collection;Science;Sister;success;Technology;tool;tool development;Training;Training and Education;Translating;Trust;TRUST principles;Update;Variant;Work;working group

PROJECT_TITLE: Community Outreach and Adoption


PROJECT_TERMS: Address;Adopted;Adoption;Collaborations;Communication;Communities;community engagement;Data;data access;Development;Education and Outreach;Educational Activities;Educational Materials;Educational workshop;Effectiveness;ethical, legal, and social implication;Feedback;Foundations;functional genomics;Future;genetic counselor;Genomics;Goals;Graph;human pangenome;human reference genome;implementation strategy;Infrastructure;innovation;International;international partnership;Lead;Leadership;Library Materials;Link;Maintenance;Manuscripts;Medical;meetings;member;Methods;Molecular;Monitor;National Human Genome Research Institute;Newsletter;Nuclear;Online Systems;operation;outreach;pan-genome;Participant;Persons;Policies;Population;Press Releases;programs;Protocols documentation;Publications;recruit;Reporting;repository;Research;Research Design;Research Personnel;Resource Sharing;Resources;social media;success;Technology;telomere;tool;Training;Training and Education;Update;web site;webinar;Work;working group;Writing

PROJECT_TITLE: HGRP Logistical Coordinating Center


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MILFORD

ORG_NAME: INSTANOSIS, INC.

ORG_STATE: DE

PHR: Project Narrative We propose to develop and commercialize the first regulatory approved over-the-counter test for rapid, sensitive and instrument-free fentanyl detection, using our InstaStrip technology. The resources developed in this proposal will serve as a blueprint to allow us to quickly modify the technology for other analytes and respond rapidly to emerging drug threats.

PI_NAMEs: WANG, PING ;XIA, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Affect;Agreement;Antibodies;Benchmarking;Biological Assay;Clinical;Clinical Management;Clinical Sensitivity;Collection;commercialization;Communication;Contracts;cross reactivity;Data;design;Detection;detection sensitivity;Development;Device Designs;Devices;Diagnostic;diagnostic screening;Disease Outbreaks;dosage;drug testing;Enrollment;Ensure;Fentanyl;fentanyl analog;fentanyl test;Frequencies;Funding;Health Professional;Hospitals;Hour;Human;Infrastructure;Instruction;instrument;instrumentation;Laboratories;Legal patent;manufacture;Manufacturer;manufacturing process;Marketing;Mass Spectrum Analysis;meetings;Methods;Monoclonal Antibodies;Naloxone;Narcotics;National Institute of Drug Abuse;novel;Opioid;Overdose;overdose death;Patients;Performance;Pharmaceutical Preparations;Phase;point of care;Population;prototype;Public Health;Publishing;rapid detection;Rapid screening;rapid test;Reagent;Regulatory Pathway;Reporting;Research Design;Residual state;Resources;Sampling;screening;Sensitivity and Specificity;Small Business Innovation Research Grant;Specificity;Speed;synthetic opioid;System;Technology;Testing;Time;Tube;United States;Urine;usability;Validation;validation studies;Ventilatory Depression;verification and validation;Visual;Work

PROJECT_TITLE: Rapid, Instrument-free and High Sensitivity Over-the-counter Urine Fentanyl Testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SUY-S (J1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases

ORG_CITY: Raleigh

ORG_NAME: GLYCAN THERAPEUTICS CORPORATION

PHR: Project Narrative Heparin and low-molecular weight heparins (LMWHs) are mixtures of highly sulfated polysaccharides isolated from animal tissues. In this project, Glycan Therapeutics plans to use an innovative chemoenzymatic technology to synthesize heparin-like glycan. The project is designed to improve the safety of heparin drugs, and to reduce the cost of heparin synthesis.

PI_NAMEs: PAGADALA, VIJAYAKANTH  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Animal Model;Animal Sources;animal tissue;Animals;Anticoagulants;Biological Assay;Carbohydrates;Cells;Cessation of life;Chemicals;Clinical Trials;Complex Mixtures;Controlled Environment;cost;cost effective;dalton;depolymerization;design;Development;drug production;Enoxaparin;Ensure;Enzymes;Escherichia coli;Family suidae;flexibility;Formulation;Funding;Glycoside Hydrolases;glycosyltransferase;Goals;Grant;Hemorrhage;Heparin;heparin-induced thrombocytopenia;Human;improved;Individual;innovation;Insecta;Intestines;Investigational Drugs;Investigational New Drug Application;Label;Life;Low-Molecular-Weight Heparin;manufacture;manufacturing process;Marketing;Measures;Medicine;Metabolic Clearance Rate;method development;Methods;Modeling;Modernization;molecular mass;Monkeys;mouse model;Mus;Natural Products;nonhuman primate;Oligosaccharides;Outcome;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;pharmacophore;Phase;phase 2 study;Plasma;Polysaccharides;Preparation;Process;Production;Property;Protocols documentation;Recombinants;Reproducibility;Risk;Route;Safety;Sampling;scale up;side effect;Small Business Innovation Research Grant;Structure;Sulfate;sulfotransferase;Technology;Therapeutic;Toxic effect;Universities;Work

PROJECT_TITLE: Development of anticoagulant sulfated glycans


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PUBLIC HEALTH RELEVANCE The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and anergic stroma that inhibits vascular perfusion, suppresses immune function, and reduces tumor permeability to drugs and immune cells. We propose developing and evaluating a novel oncolytic virus modified to selectively deliver stroma-degrading enzymes to enhance the expression of neoantigens and increase tumor immunogenicity as well as immune cell infiltration. Currently, advanced PDAC patients have limited treatment options; thus, this project will address a critical unmet need for more effective therapies.

PI_NAMEs: NAGALO, BOLNI MARIUS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Alloantigen;Allogenic;Biodistribution;Biological Availability;Blood Vessels;cancer immunotherapy;cancer type;carcinogenesis;Cell Death;Cells;clinical application;Collagen;collagenase;Cytotoxic T-Lymphocytes;Development;Directed Molecular Evolution;Drug Delivery Systems;effective therapy;Enzymes;Glycoproteins;high reward;high risk;Human;Hyaluronic Acid;Hyaluronidase;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immune response;immunogenicity;immunoregulation;improved;innovation;Major Histocompatibility Complex;Malignant neoplasm of pancreas;Mediating;Modification;mouse model;multiple myeloma M Protein;Mus;neoantigens;neurotoxicity;novel;novel strategies;oncolysis;oncolytic vector;oncolytic virotherapy;Oncolytic viruses;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Perfusion;Permeability;Pharmaceutical Preparations;preclinical study;public health relevance;refractory cancer;Research;Safety;Survival Rate;Technology;therapy resistant;Toxicology;Treatment Efficacy;tumor;tumor microenvironment;Tumor Promotion;vector;Vesicular stomatitis Indiana virus;Viral;Virus;Work

PROJECT_TITLE: Novel Strategies to Enhance Drug Delivery and Tumor Immunogenicity in Pancreatic Cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Obesity

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Angiogenesis is a key pathogenic component of obesity and at least 70 known diseases, and it is primarily driven by the vascular endothelial growth factor receptor (VEGFR) and its family of VEGF ligands. However, targeting VEGF alone has not achieved the promise of stable vascular control, so new approaches are needed to control and direct vascular development. The purpose of these studies is to biologically and computationally assess how the new theory of cross- family signaling may control vascular signaling at the molecular, protein, and cellular levels.

PI_NAMEs: IMOUKHUEDE, PRINCESS IZEVBUA (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adipose tissue;angiogenesis;Area;Binding;Blood Vessels;Cells;Computer Models;Data;design;Development;Directed Molecular Evolution;Disease;Disease Progression;Endothelial Growth Factors Receptor;Engineering;experimental analysis;Family;Goals;Growth Factor;Human;in silico;innovation;kinetic model;Lead;Ligands;Measures;member;migration;Modeling;Molecular;novel;novel strategies;Obesity;Pathogenicity;Platelet-Derived Growth Factor;Process;Proliferating;Property;protein structure;Proteins;Receptor Activation;Regulation;Research;response;Signal Transduction;simulation;Statistical Data Interpretation;Structure;System;Systems Biology;Testing;theories;Vascular Diseases;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Developing Deterministic Computational Models and Statistical Analysis of VEGF+PDGF Cross-Family Signaling in Adipose Tissue

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: FANNIN PARTNERS, LLC

PHR: PROJECT NARRATIVE The incidence and prevalence of methamphetamine and other stimulant use disorders have been steadily increasing to epidemic proportions, with no approved drug treatments available. Fannin is developing a drug with a novel mechanism of action that reduces neuroinflammation and has shown therapeutic potential in animal models of cocaine-use disorder. Here, we propose to further advance the compound through testing in preclinical animal models and complete further testing to demonstrate safety and efficacy and to prepare for eventual clinical testing.

PI_NAMEs: LACKOVIC, JACOB EDWARD;VARADHACHARY, ATUL  (contact)

PROGRAM_OFFICER_NAME: KARUPPAGOUNDER, SARAVANAN SHANMUGAM

PROJECT_TERMS: abuse liability;Adverse event;AMPA Receptors;Animal Model;Animals;Anti-Inflammatory Agents;Applications Grants;Area;awake;Behavior;behavioral sensitization;Binding;Biological Availability;Blood specimen;Body Weight;Brain;Brain region;Cannabis;Cells;Central Nervous System;Clinical;Cocaine;Cocaine use disorder;Consumption;cost estimate;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Development;Dopamine;Dose;drug craving;Drug Kinetics;drug seeking behavior;efficacy study;Environment;Enzymes;Epidemic;Evaluation;experience;extracellular;Family;food consumption;glutamatergic signaling;Glutamates;Health;Homeostasis;Immune;Impairment;in vivo;Incidence;Inflammatory;inhibitor;innovation;Inpatients;Investigation;Link;Mediating;Mediator;Medical;Methamphetamine;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;Microdialysis;Microglia;Modeling;Monitor;Monoamine Oxidase;Morphology;Nerve;Nervous System Disorder;neuroinflammation;Neuronal Plasticity;Neurons;neurotransmission;Neurotransmitters;novel;novel therapeutics;Nucleus Accumbens;Ophthalmology;Opioid;Oral;Oxidative Stress;Pathologic;Pathway interactions;PDE4B;Penetration;Pharmaceutical Preparations;Pharmacotherapy;phosphodiesterase IV;Phosphorylation;Play;Positioning Attribute;pre-clinical;presynaptic;Prevalence;Rattus;Reinforcement Schedule;research clinical testing;reuptake;Role;Rolipram;Safety;Schedule;Self Administration;Signal Pathway;Signal Transduction;small molecule;Stimulant;stimulant use;stimulant use disorder;substance use;Substance Use Disorder;Synapses;Testing;Therapeutic;Tissue Sample;Toxic effect;Toxicokinetics;Toxicology;Training;transmission process;Treatment Cost;Vomiting;Withdrawal;Work

PROJECT_TITLE: Investigation of a Novel PDE4B Inhibitor for Stimulant Use Disorder


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Regenerative Medicine;Wound Healing and Care

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative Corneal keratocytes play a central role in fundamental biological processes such as developmental morphogenesis, normal wound healing, and corneal scarring. In this proposal, we request supplemental funding to acquire a microscope stage CO2 incubator system that will allow us to perform live-cell analysis, time lapse imaging, and provide us with multi-modal information. The acquisition of this live-cell imaging system will allow us to characterize interactions between keratocytes and their microenvironment in real time, and provide unprecedented insights into the role of key biophysical signaling pathways on the differentiation of keratocytes.

PI_NAMEs: SCHMIDTKE, DAVID W (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Biochemical;Biological Process;Biomechanics;Biophysics;Blindness;Carbon Dioxide;cell behavior;Cells;Cellular Morphology;Collagen Fibril;Cornea;corneal scar;Cues;Data;Development;Dimensions;Elasticity;Extracellular Matrix;Extracellular Matrix Proteins;Feedback;Fibrosis;Funding;Growth Factor;Image;imaging system;Immobilization;improved;Incubators;insight;instrumentation;Knowledge;live cell imaging;Measures;Microscope;migration;Modeling;Morphogenesis;Motor;multimodality;novel;Parents;Pattern;Phenotype;Play;Proliferating;Proteins;regenerative;Regulation;repaired;replacement tissue;response;Role;Signal Pathway;Stimulus;Stromal Cells;System;temporal measurement;Testing;Time;Tissue Engineering;wound healing;wound injury

PROJECT_TITLE: Regulation of Corneal Keratocyte Differentiation through the Integration of Biochemical, Biomechanical and Topographic Cues


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE The Massachusetts HIV/Justice Research Network will develop and study the outcomes and implementation of an intervention to increase access to carceral HIV healthcare. Findings will have implications for HIV treatment and prevention to end the HIV epidemic in jail populations.

PI_NAMEs: EVANS, ELIZABETH A.;WURCEL, ALYSSE GAIL (contact)

PROJECT_TERMS: acceptability and feasibility;Address;AIDS prevention;Authorization documentation;Boston;care coordination;Caring;Collection;Communication Methods;Communities;Community Healthcare;community partners;Community Services;contextual factors;Continuity of Patient Care;cost effective;cost estimate;County;Data;Data Set;data warehouse;design;Development;Diagnostic Services;Disease Outbreaks;economic value;effectiveness/implementation study;Epidemic;Event;experience;formative assessment;Foundations;Future;Geography;Goals;Health Care Costs;Health Care Sector;health care service;Health Status;Healthcare;HIV;HIV Seronegativity;Human immunodeficiency virus test;implementation intervention;implementation study;Imprisonment;improved;Individual;Infection;insight;Intervention;Jail;Justice;Legal;Legal system;Link;Lived experience;Massachusetts;Measures;Medicaid;medication for opioid use disorder;Methods;Modality;Modeling;mortality;Opioid;opioid use disorder;Outcome;Outcome Measure;Outcome Study;outreach;outreach program;Overdose;Patient Outcomes Assessments;Patient Self-Report;Penetration;Persons;Pharmaceutical Preparations;Phase;pilot test;pilot trial;Policy Maker;Population;Population Research;pre-exposure prophylaxis;prevent;Prevention;prevention service;primary outcome;process improvement;programs;Public Health;public health relevance;Race;Recommendation;reincarceration;Research;Resources;response;safety net;secondary outcome;Site;success;System;Testing;treatment as usual;Treatment outcome;treatment services;uptake

PROJECT_TITLE: Massachusetts HIV and Justice-Involved Populations Research Network


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: 8. PROJECT NARRATIVE This application seeks to explore the efficacy, safety, acceptability and cost-effectiveness of long-acting antiretroviral therapy (LA ART) on viral suppression among virally unsuppressed people who inject drugs in New Delhi, India. If successful, this application will generate evidence to support a new indication for the use of LA ART and transform the delivery of ART in a disenfranchised vulnerable population with high mortality.

PI_NAMEs: SOLOMON, SUNIL SUHAS (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Adherence;Africa South of the Sahara;antiretroviral therapy;arm;Clinical Treatment;Clinical Trials Design;Cost Analysis;cost effectiveness;Cost Savings;Drug usage;efficacy evaluation;Ethnography;experience;Exposure to;health care delivery;Health Personnel;HIV;Homelessness;improved;Incidence;India;Individual;Infection;Injectable;Injecting drug user;Intervention;Intramuscular;Intramuscular Injections;Lamivudine;low and middle-income countries;Modeling;mortality;Needle-Exchange Programs;Network-based;open label;Oral;outreach;Participant;Pattern;Persons;Phase;Population;Randomized;randomized, clinical trials;response;RNA;Role;Safety;Scholarship;Secondary Prevention;Site;social structure;subcutaneous;substance use;Surveys;Tenofovir;three-arm study;transmission process;treatment arm;treatment as prevention;Unemployment;Vial device;Viral;Vulnerable Populations;Work

PROJECT_TITLE: Long-Acting Injectables for Treatment of HIV among PWID (LIFT HIV)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Rehabilitation;Substance Misuse

ORG_CITY: Lehi

ORG_NAME: PHOTOPHARMICS, INC.

ORG_STATE: UT

PHR: PROJECT NARRATIVE The objective of this proposal is to improve a novel device to treat anxiety and drug use in subjects with opioid use disorder. The rationale for this proposal is predicated on the belief that non-invasive, non-pharmacological activation of peripheral sensory receptors by specific mechanical stimulation modulates brain substrates dysregulated by opioid use disorder. Our novel technology has much promise to target the brain mechanisms underlying the recreational use and abuse potential of opioids, and its development will pave the way for an FDA-approved de novo device to reverse dependence on opioids and save lives and resources throughout the world.

PI_NAMEs: ADAMS, DANIEL NATHAN (contact);STEFFENSEN, SCOTT C

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: abuse liability;Acute;Alcohol dependence;alcohol effect;Alcohol withdrawal syndrome;Alcohols;Analgesics;Anxiety;Anxiety Disorders;anxiety reduction;Attention;Behavior Therapy;Behavioral;Belief;Biological Markers;Blood;Brain;Catecholamines;Cervical;Cervical spine;Chronic;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collaborations;college;commercial prototype;commercialization;comorbidity;Corpus striatum structure;Counseling;craving;Databases;delta opioid receptor;Dependence;design;Development;Device Designs;Devices;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Drug Rehabilitation Centers;Drug usage;efficacious treatment;endogenous opioids;Epidemic;Evaluation;FDA approved;Female;Florida;Frequencies;gamma-Aminobutyric Acid;generalized anxiety;heterodyning;Home;Hour;Human;improved;indexing;Legal patent;Leukocytes;male;Measures;Mechanical Stimulation;Mechanoreceptors;mesolimbic system;Midbrain structure;Modification;Molecular;Monitor;National Institute of Drug Abuse;neurochemistry;Neurons;new technology;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid use;opioid use disorder;opioid withdrawal;Osteopathic Medicine;Pain;Pain Clinics;pain rehabilitation;Paper;Parents;Pathway interactions;Patient Outcomes Assessments;Patients;patients who use opioids;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;phase 1 study;Phase I Clinical Trials;Phase II Clinical Trials;phase II trial;Physiological;Placebos;point of care;Postdoctoral Fellow;pre-clinical;preclinical study;prescription opioid;prevent;Property;prototype;receptor expression;Recording of previous events;Recreation;recruit;Regulation;Rehabilitation Centers;Relapse;Reporting;Research Personnel;Resources;Rewards;Rodent;Safety;safety testing;Sensory Receptors;Spinal;Stress;Students;System;Technology;Telemetry;Treatment Efficacy;United States;United States National Institutes of Health;usability;Utah;Ventral Tegmental Area;vibration;volunteer;Withdrawal;withdrawal-induced anxiety

PROJECT_TITLE: Amelioration of opioid use disorder with heterodyned whole body vibration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE This proposed study addresses a highly relevant public health question: how people living with HIV and affected by disaster access and remain engaged in HIV care. This study will take place in Ukraine, which continues to experience one of the highest HIV rates in Europe and has been devastated by Russia’s 2022 invasion and ongoing war. The information gained through this study has the potential to inform the development of policies and practices to help people living with HIV maintain access to care in contexts of instability.

PI_NAMEs: MOROZOVA, OLGA ;OWCZARZAK, JILL  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Acute;Address;Adopted;Affect;antiretroviral therapy;Appointment;Area;care outcomes;Caring;Characteristics;Chronic;Clinical;Communities;Complex;Conflict (Psychology);Consequences of HIV;Coping Skills;development policy;disability;Disasters;Distal;Drug usage;Drug user;Economics;Enabling Factors;Environmental Risk Factor;Epidemic;Europe;Event;experience;Exposure to;follow-up;Health;health care service;Health Services;Health Services Accessibility;Healthcare;HIV;HIV diagnosis;HIV Seropositivity;Human;Individual;Infrastructure;injection drug use;injured;innovation;Interruption;Invaded;Left;Life;Link;Longitudinal cohort;marginalization;Measures;Mediating;Methods;Military Personnel;Modeling;Natural experiment;Outcome;patient engagement;Persons;Pharmacotherapy;Physical environment;Policies;Population;Poverty;Prevalence;Prior Therapy;Productivity;Provider;psychologic;psychological distress;Public Health;Randomized;Research;residence;resilience;Resources;Route;Russia;secondary outcome;service providers;Services;Shapes;skills;social;Social Conditions;Social Environment;social factors;social health determinants;Social Network;social service provider;Social support;stressor;structural determinants;substance use;supply chain;therapy adherence;Time;transmission process;Trauma;trauma exposure;Treatment outcome;treatment risk;trend;Ukraine;Viral;Vulnerable Populations;War;Water;Work

PROJECT_TITLE: The Effects of Complex Humanitarian Disaster on HIV Care Engagement and Health Outcomes among HIV-Positive People Who Use Drugs in Ukraine


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Microbiome;Neurosciences;Stimulant Use and Misuse

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: PROJECT NARRATIVE Addiction is a chronic, relapsing disorder that affects millions of people in the United States and worldwide, and yet no successful treatments have been developed. In the past years, the composition and type of bacteria that inhabit our gut (the gut microbiota) has emerged as a crucial regulator of brain maturation, function, and response to different diseases, including addiction; however, the mechanisms behind this communication remain mostly unknown. This project proposes a novel multidisciplinary approach directed to characterize clear and mechanistically defined interactions between the gut microbiota, psychostimulant use, and addiction, which can lead to the development of more successful evidence-based systemic interventions for treating this debilitating psychopathology. |Contact PD/PI: Cuesta, Santiago

PI_NAMEs: CUESTA, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: addiction;Adult;Affect;Animal Model;Bacteria;bacterial genetics;Bacterial Physiology;Behavior;behavior test;Brain;Chronic;Chronic Disease;Communication;cost;Crime;Data;Development;Disease;Equipment;evidence base;experience;fecal microbiome;Goals;gut microbiome;gut microbiota;gut-brain axis;Health;Healthcare;Human;In Vitro;in vivo Model;innovation;interdisciplinary approach;Knowledge;Mediator;member;Mental disorders;metabolomics;Metagenomics;microbial;microbial composition;Microbiological Techniques;Microbiology;microbiome;Molecular;multidisciplinary;Mus;neurobehavioral;Neuropsychology;Neurosciences;novel;pandemic disease;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;Productivity;Protocols documentation;Psychopathology;psychostimulant;Recurrent disease;Relapse;Resources;response;Running;Signal Transduction;social;stimulant exposure;stimulant use;Substance Use Disorder;systemic intervention;United States;Work

PROJECT_TITLE: Multidisciplinary Characterization of the Gut-Brain Axis in Addiction


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The experiments proposed aim to examine the neural mechanisms of active avoidance learning and explore how these mechanisms are modulated by fear extinction learning circuits. We will use a novel conditioning and avoidance paradigm to gather functional MRI and subjective reports data from healthy controls and from patients diagnosed with post-traumatic stress disorder (PTSD). The anticipated impact is to enhance our understanding of the neural mechanisms of adaptive and maladaptive avoidance responses, reduce the translation gap in this area between rodents and human studies, and explore potential novel targets for advancing the treatment of PTSD.

PI_NAMEs: MILAD, MOHAMMED R (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Amygdaloid structure;Area;avoidance behavior;Avoidance Learning;Brain;Characteristics;Color;conditioned fear;Conditioned Stimulus;conditioning;Control Groups;Corpus striatum structure;cost;Data;Data Reporting;Decision Making;design;Diagnosis;Dorsal;Endowment;experience;Experimental Designs;experimental study;Extinction;Financial cost;Fright;Functional Magnetic Resonance Imaging;Future;Hippocampus;Human;Impairment;indexing;Learning;learning extinction;Light;Literature;Measures;Mediating;Methods;Modeling;neural;neural correlate;neuroimaging;neuromechanism;neuropathology;novel;Nucleus Accumbens;Participant;Patients;Phase;Play;Post-Traumatic Stress Disorders;Pre-Clinical Model;Prefrontal Cortex;prevent;Price;Probability;Psychopathology;random forest;Research;response;Rewards;Rodent;Role;Shock;Signal Transduction;Stimulus;success;Symptoms;Testing;Training;Translating;Translations;trauma exposure;Ventral Tegmental Area;willingness to pay

PROJECT_TITLE: Neural correlates of active avoidance learning and their interactions with fear extinction mechanisms in PTSD patients

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

PHR: Project Narrative The experiments proposed are aimed to understand how timing and location of transcranial magnetic stimulation (TMS) in humans will impact their ability to reduce conditioned fear responses and impact the activation of their brain regions involved in fear regulation. We will use a novel TMS approach to vary timing and location of its delivery so that we can characterize and establish best time and location to obtain optimal impact on fear inhibition, and then test these parameters in PTSD patients and see if such can rescue extinction deficits in PTSD. The anticipated impact is to enhance our understanding of the neural mechanisms of associated with TMS use and explore potential novel approaches for advancing PTSD treatment.

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: Affect;Amygdaloid structure;Anatomy;Anterior;Anxiety;anxiety sensitivity;Brain;Brain region;cingulate cortex;Clinical;Clinical Data;Collection;conditioned fear;Conditioned Reflex;Coupled;Cues;Data;Dorsal;Effectiveness;experimental study;Extinction;Fright;frontier;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Genetic Complementation Test;Hippocampus;Human;Hypersensitivity skin testing;indexing;Individual;interest;Knowledge;Location;mathematical model;Mathematics;Measures;Memory;memory consolidation;Memory impairment;Methodology;Modeling;neural circuit;neural correlate;neuromechanism;neuropsychiatry;neuroregulation;novel;novel strategies;Outcome;outcome prediction;Participant;Patients;Population;Post-Traumatic Stress Disorders;predictive modeling;Prefrontal Cortex;Psychiatry;Rattus;recruit;Regulation;response;Rodent;Running;Sampling;Shock;Side;Statistical Models;Stimulus;success;Surface;Testing;Time;tool;Training;Transcranial magnetic stimulation;Variant

PROJECT_TITLE: Neuromodulation of the fear extinction circuit using temporally and anatomically specific TMS in humans


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Lung;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: Pittsburgh

ORG_NAME: RESILIENT LIFESCIENCE, INC.

ORG_STATE: PA

PHR: Project Summary This proposal is submitted in direct response to RFA-DA-23-021 Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44). Persons of all ages with Opioid Use Disorder (OUD) are at risk for opioid overdose, which can cause Opioid Induced Respiratory Depression (OIRD), leading to hypoxia and death. Most overdose deaths in the U.S. occur without anybody else present, preventing bystander administration of the lifesaving drug naloxone. Technology to detect OIRD and issue an emergency signal could help ensure responders arrive at the scene of an overdose to administer naloxone in a timely fashion. Currently, there are no FDA-approved products to detect opioid overdose or OIRD that are designed for continuous wear in a discreet location on the body. Resilient Lifescience’s goal is to develop a wearable medical device that can detect OIRD and issue an emergency alert, calling a friend, loved one, or emergency medical service to the scene. The central hypothesis to test in this proposed work is that a patch-based wearable medical device worn on the abdomen will be effective at detecting OIRD in patients and will be a well-accepted form factor for use by individuals with OUD. The overall objective of Phase I in this proposal is to determine technical feasibility of the project by showing that the device is effective at measuring oxygen saturation using reflective photoplethysmography (PPG) on the abdomen and to demonstrate commercial viability of the product by showing that individuals with OUD will adhere to use of the product. Resilient Lifescience will do this by 1) completing feasibility research to evaluate the device’s ability to measure oxygen saturation using reflective PPG on the abdomen, 2) executing user-centered industrial design, and 3) demonstrating that opioid users will adhere to use of the device during a two-week pilot study. The overall objective of Phase II in this project is to de-risk the commercialization of the device by demonstrating that the device is suitable for manufacture, passes required compliance testing, and is effective at detecting OIRD within patients receiving opioid analgesia in a hospital setting. The research team will accomplish this by 1) reaching design-freeze and soliciting quotes for small batch production of the device, 2) testing the ability of the device to detect OIRD in a hospital setting, and 3) completing required electromagnetic compatibility, biocompatibility, ingress protection, and human factors testing for the device.

PI_NAMEs: HOLDEN, BRADFORD A (contact)

PROJECT_TERMS: Abdomen;Accelerometer;Adherence;Adhesions;Adhesives;Affect;Age;Algorithms;American;Apnea;Area;biomaterial compatibility;Calendar;Carbon Dioxide;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;commercialization;design;Detection;Development;Device Designs;Devices;Diagnostic;effective therapy;Electromagnetics;Emergency medical service;Emergency Situation;Ensure;Environment;experience;feasibility research;Freezing;Friends;Future;Goals;Guidelines;Health;Home;Hospitals;Hour;Human;Hypoxia;illicit opioid;Individual;Industrialization;Life;Location;loved ones;manufacture;Measures;Mechanics;Medical Device;Methods;Monitor;Naloxone;National Institute of Drug Abuse;Opioid;Opioid Analgesics;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid user;Overdose;overdose death;overdose risk;Oxygen;Participant;Patients;performance tests;Persons;Pharmaceutical Preparations;Phase;Photoplethysmography;Pilot Projects;prevent;Production;prototype;Research;Research Design;resilience;respiratory;response;Risk;Sample Size;Sensitivity and Specificity;Signal Transduction;Small Business Innovation Research Grant;Specificity;stimulant use disorder;Technology;Testing;Therapeutic;United States Food and Drug Administration;United States National Institutes of Health;user centered design;Validation;validation studies;Ventilatory Depression;wearable device;Work

PROJECT_TITLE: Developing a wearable medical device to detect opioid overdose


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;HIV/AIDS;Harm Reduction for Substance Misuse;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Amidst an explosive increase in overdose deaths linked to stimulants (e.g., cocaine, methamphetamine) along with fentanyl, it is unknown what proportion of deaths are due to unintentional exposure to fentanyl, particularly in people living with or at risk of HIV who have had relatively prevalent stimulant use alone. We propose a randomized controlled trial to test an innovative approach to opioid overdose prevention that repurposes a known injectable, long-acting opioid blocking medication (naltrexone) and when possible, couples it with injectable HIV prevention or treatment medication. Aiming to shield people living with or at risk of HIV who use stimulants from unintentional opioid exposure, this study seeks to combine overdose prevention with HIV care, addressing two critical health concerns in one integrated approach.

PI_NAMEs: APPA, AYESHA A (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;AIDS prevention;alcohol use disorder;antiretroviral therapy;Biological Markers;California;Caring;Cessation of life;Clinic;Cocaine;cohort;County;Couples;Creativeness;Death Rate;Drug user;Effectiveness;Epidemiology;experience;Exposure to;Fentanyl;fentanyl exposure;General Hospitals;Harm Reduction;Health;HIV;Home;Individual;Injectable;innovation;insight;Intramuscular;Life Expectancy;Link;Medicine;Methamphetamine;Methods;Naltrexone;novel;Opioid;Opioid Antagonist;opioid exposure;opioid mortality;opioid overdose;opioid use;oral HIV;overdose death;overdose prevention;participant interview;Patients;Persons;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevent;Prevention;Preventive measure;Randomized;Randomized, Controlled Trials;Research;Risk;San Francisco;Stimulant;stimulant use;substance use;Testing;tool;United States;Universities;ward

PROJECT_TITLE: Taking Our Shot: Extended-Release Naltrexone as Opioid Overdose Pre-Exposure Prophylaxis (PrEP) in People Using Stimulants Living With or At Risk of HIV


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposed work on the development of two new mouse models of age-related macular degeneration (AMD) and testing a new potential therapy (oral D-DHA) is important for protecting human health because AMD can cause loss of central vision. Current treatments are limited, especially for the advanced dry (geographic atrophy) form of the disease. If these mouse models are protected by D-DHA, this will also implicate DHA oxidation as a key pathogenic mechanism in the models.

PI_NAMEs: DUNAIEF, JOSHUA L (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acids;Acute;Age;Age related macular degeneration;Antioxidants;Atrophic;Cessation of life;Complement;Data;Deuterium;Development;Diet;Disease;Disease Progression;Dose;Dryness;Euthanasia;Evaluation;Functional disorder;Gender;geographic atrophy;glutathione peroxidase;Goals;Growth;Health;Histology;Human;Hydrogen;in vivo imaging;inducible Cre;Injections;Iron;Isotopes;Knockout Mice;Lipid Peroxidation;Lipids;Mass Spectrum Analysis;Measures;Membrane Lipids;Modeling;Molecular;Morphology;mouse model;Mus;Nonexudative age-related macular degeneration;novel;novel therapeutics;Oral;Oxidants;oxidation;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacodynamics;photoreceptor degeneration;Photoreceptors;pi bond;Polyunsaturated Fatty Acids;pre-clinical;Predisposition;prevent;Prevention;Publishing;Reaction;Research Personnel;Resistance;response;Retina;Rod;Site;sodium iodate;Stress Tests;Testing;Therapeutic;Thinness;Time;treatment effect;Vision;Work

PROJECT_TITLE: Development of Two Novel AMD Models for Evaluation of RPE Protection by the Novel Antioxidant D-DHA

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Viruses in the Reoviridae family infect a wide range of hosts, including animals, plants, fungi, and bacteria; within this family, rotaviruses cause 450,000 deaths worldwide each year, and BTV kills livestock, with devastating economic and social consequences. The proposed structural and functional studies focus on BTV and CPV to provide structural answers to fundamental questions of replication of these and other dsRNA viruses. The results will provide profound insight into the structural basis of dsRNA virus spread and inform rational development of anti-viral drugs and vaccines against these and other viruses.

PI_NAMEs: ZHOU, Z HONG (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Animals;Anti-viral Response;antiviral drug development;Aquareoviruses;Bacteria;Basic Science;Biochemical;Biological Models;Bluetongue virus;Capsid;Capsid Proteins;Cells;Cessation of life;Child;Chimeric Proteins;Classification;Communities;comparative;Complex;Cryoelectron Microscopy;Cues;Cytoplasm;Cytoplasmic Polyhedrosis Viruses;Detection;Double Stranded RNA Virus;Double-Stranded RNA;Drug Delivery Systems;Economics;electron tomography;Electrons;endosome membrane;Engineering;Environment;Enzymes;Event;Family;Flu virus;Funding;fungus;Gastroenteritis;General Population;Genetic Transcription;Genome;genomic RNA;Goals;Grant;Health Sciences;HIV;Human;In Situ;Infectious bursal disease virus;Insect Viruses;Insecta;insight;interest;Invaded;Ions;Iris;Lead;Life Cycle Stages;Link;Literature;Livestock;member;Membrane Proteins;Messenger RNA;Modeling;Molecular Biology;Molecular Conformation;mRNA capping;Multienzyme Complexes;Mutagenesis;N-terminal;nanometer resolution;novel;nucleoside triphosphatase;particle;pathogen;Pattern;Phase;Plants;Polymerase;Proteins;Public Health;Publishing;reconstruction;Recording of previous events;Reoviridae;Reovirus;replicator;Rhesus;RNA;RNA Caps;RNA replication;RNA-Directed RNA Polymerase;Role;Rotavirus;social;Structure;Surface;System;Techniques;Technology;Testing;Transcriptional Activation;Trichomonas vaginalis;vaccine development;Vaccines;Variant;Viral;Viral Genome;Virion;Virus;Virus Assembly;virus core;Visualization;Work

PROJECT_TITLE: Genome structure, transcription and packaging of dsRNA viruses

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE The Genome Center will lead the prioritization, recruitment, and selection of samples from study participants representing global diversity consented for open access data release. With those samples, we will produce 200 new, very high-quality haplotype-resolved, and annotated, human genome assemblies for inclusion in the human pangenome reference resource. We propose to complete this work with a team of ethical, legal and social implications (ELSI) scholars who will be embedded in our effort.

PI_NAMEs: COOK-DEEGAN, ROBERT MULLAN;EICHLER, EVAN ;JARVIS, ERICH D;KENNY, EIMEAR ELIZABETH;MIGA, KAREN HAYDEN (contact);WANG, TING

PROJECT_TERMS: Address;Adoption;Algorithms;benefit sharing;biobank;California;Callback;cohort;Collaborations;Collection;Communities;Consensus;Consent;cost;cost effectiveness;Country;Data;data access;data dissemination;data repository;Data Science;data sharing;Decision Making;design;Disease;DNA;Ensure;Epigenetic Process;Equity;established cell line;ethical, legal, and social implication;Ethics;Evaluation;Future;Gene Frequency;Generations;Genetic Variation;Genome;genome sequencing;genomic data;Genomic medicine;Genomics;Goals;Haplotypes;health disparity;Human;Human Genome;human pangenome;human reference genome;Human Resources;improved;Indigenous;indigenous community;Individual;Informatics;International;Los Angeles;lymphoblastoid cell line;Medical center;National Human Genome Research Institute;Nature;New York;novel;open data;operation;Output;outreach;pan-genome;Participant;Patients;Persons;Phase;Population Genetics;precision medicine;prevent;Process;Production;programs;prospective;Protocols documentation;recruit;Repetitive Sequence;Research;Research Methodology;Research Personnel;Resources;Role;sample collection;Sampling;Sampling Studies;social;Software Tools;Specialist;Strategic Planning;Structure;Technology;telomere;transcriptomics;Underrepresented Populations;Universities;Variant;Visualization;Work;working group

PROJECT_TITLE: Center for Human Genome Reference Diversity


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: CLEAR SCIENTIFIC, LLC

PHR: PROJECT NARRATIVE Co-use of fentanyl with xylazine, a sedative for which naloxone, the standard of care for opioid intoxication is ineffective, has reached crisis levels in the US, with xylazine-positive overdose deaths increasing by 1,127% in the South and over 100% in all other regions between 2020 and 2021. The proposed work addresses the urgent need for a reversal agent for combinations of fentanyl and xylazine, compatible with naloxone, that restores respiration and reverses xylazine-induced sedation. Such a therapeutic would save lives, improve patient outcomes, and relieve burden on already strained hospital resources.

PI_NAMEs: LI, XINHUA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Acceleration;Address;Advanced Development;Affect;analog;Animals;Antidotes;Binding;Biodistribution;Biological Availability;Blood;Breathing;Canis familiaris;Clinical;Clinical Research;combat;comparative efficacy;Development;Dose;Drug Kinetics;Effectiveness;efficacy study;Encapsulated;Evaluation;Excipients;Excretory function;Fentanyl;fentanyl overdose;fentanyl use;Formulation;Goals;Guidelines;Health;Hospitals;Human body;Hydrophobicity;improved;In Vitro;International;Intoxication;Intramuscular;Intramuscular Injections;Lead;lead candidate;Methamphetamine;Morbidity - disease rate;Naloxone;novel;opioid overdose;Osmolalities;Outcome;Overdose;overdose death;Patient-Focused Outcomes;Plasma;primary endpoint;Rattus;Regulatory Pathway;Resources;Respiration;response;restoration;Saline;secondary endpoint;Sedation procedure;sedative;Selection Criteria;small molecule;Solubility;standard of care;symposium;Symptoms;Therapeutic;therapeutic candidate;Toxic effect;Tranquilizing Agents;Urine;Ventilatory Depression;Work;wound;Xylazine

PROJECT_TITLE: A Novel Reversal Agent for Treatment of Overdose from the Combination of Fentanyl and Xylazine


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative The prevention and treatment of obesity, diabetes, and kidneys disease are high priorities for researchers, clinicians, and members of the public. The overall goal of the University of Utah STEP-UP coordinating center grant is to provide an integrated career development training to 11th and 12th grade high school students in Region C. Training will develop skills and competencies needed to conduct impactful research in preparation for advanced education.

PI_NAMEs: BRUSSEAU, TIMOTHY A;LUCERO, JULIE E (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;Admission activity;Area;Awareness;Behavioral Research;Behavioral Sciences;career;career development;Clinical Research;Clinical Sciences;Collaborations;Colorado;comorbidity;Competence;Creativeness;Dedications;Degree program;design;Diabetes Mellitus;Education;Elements;eleventh grade;Enrollment;experience;Exposure to;Extramural Activities;Faculty;follow-up;Goals;Grant;hands on research;Health;Health Disparities Research;health disparity;High School Student;higher education;insight;Institution;Interdisciplinary Study;interest;Internships;Interview;Iowa;Kansas;Kidney Diseases;Knowledge;meetings;member;Mentors;Mentorship;Mission;Missouri;Montana;National Institute of Diabetes and Digestive and Kidney Diseases;Nebraska;NIH Program Announcements;North Dakota;notch protein;Obesity;Obesity associated kidney disease;obesity treatment;Online Systems;Participant;Pathway interactions;Peer Review;Population Heterogeneity;Preparation;Prevention;Productivity;programs;Publications;Recording of previous events;recruit;Recruitment Activity;Research;research faculty;Research Personnel;Resource Development;Science;Scientist;senior faculty;Site;skill acquisition;skills;skills training;Socialization;Source;South Dakota;Students;summer research;Technical Expertise;Training;Training Programs;twelfth grade;Underrepresented Students;Universities;Utah;webinar;Writing;Wyoming

PROJECT_TITLE: U of U Step Up

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-B (J1)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: FAMILY MEDICINE

PHR: NARRATIVE Pregnancy is a "natural stress test" that may reveal higher cardiovascular disease (CVD) risks in early adulthood, thus providing opportunities for early prevention to alter the long-term trajectory of CVD in women. This project will provide the first comprehensive assessment of all major adverse pregnancy outcomes in relation to CVD risks across the life course in a large population-based cohort of 2.5 million women. The results will help improve women's health by identifying the long-term CVD risks associated with adverse pregnancy outcomes and guiding early prevention and long-term clinical care.

PI_NAMEs: CRUMP, CASEY  (contact);SUNDQUIST, KRISTINA

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Address;adverse pregnancy outcome;Affect;African ancestry;Age;Arrhythmia;Body mass index;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Child;Clinical;clinical care;clinical practice;cohort;Cohort Analysis;cost;cost efficient;Data;data registry;design;Diabetes Mellitus;disease disparity;Early Intervention;emerging adult;Family Relationship;Fetal Growth Retardation;follow-up;Genetic;Gestational Diabetes;Heart failure;high body mass index;high risk;human old age (65+);Hyperlipidemia;Hypertension;improved;Individual;innovation;Inpatients;Intervention;Journals;Life;Life Cycle Stages;Long-Term Care;Long-Term Effects;Longterm Follow-up;low socioeconomic status;Mediating;Mediation;Modeling;mortality;Mothers;Myocardial Ischemia;offspring;Outpatients;Peripheral Vascular Diseases;Phenotype;Population;population based;post pregnancy;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy disorder;Premature Birth;prevent;Prevention;prospective;Registries;Relative Risks;reproductive;Research;Risk;Risk Assessment;Risk Factors;screening guidelines;Sentinel;Siblings;Smoking;sociodemographic factors;Socioeconomic Status;Stress Tests;Stroke;Subgroup;Sweden;Testing;Time;Time trend;Woman;Women's Health;Women's mortality;young woman

PROJECT_TITLE: Adverse pregnancy outcomes and long-term risk of cardiovascular disease in women

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: IP

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Component A – Project Narrative: Vaccine effectiveness is a measure of how well a particular vaccine protects people against infection, symptomatic illness, hospitalization, and death in a real-world condition. This research aims to provide accurate estimates of the effectiveness of influenza and COVID-19 vaccines against respiratory virus- associated illness in that population, in the context of varying social determinants of health disparities.

PI_NAMEs: MURUGAN, VEL  (contact)

PROJECT_TITLE: RFA-IP-22-004, Platform to Assess Influenza and COVID-19 Vaccine Effectiveness in Underserved Arizona Populations


ORG_CITY: CLEVELAND

ORG_NAME: UNIVERSITY HOSPITALS OF CLEVELAND

ORG_STATE: OH

PHR: Project Narrative This study seeks to understand how well the Influenza and COVID-19 vaccines work in a real-world setting and how their effectiveness is changed by factors related to the person, the specific vaccine or the most common type of virus. The study also examines what affects who gets infected at home when someone has an infection, and what might change that. The researchers will also look into the body response to the infection or the vaccine to help understand what can be done to lessen the risk of getting an infection.

PI_NAMEs: SAADE, ELIE  (contact)

PROJECT_TITLE: RFA-IP-22-004, CORVETS - Cleveland Ohio Respiratory Viruses Vaccines Effectiveness across Traditional Risk Factors and Social Determinants of Health


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Component A: Michigan-Ford Initiative to Measure Vaccine Effectiveness (MFIVE): Seasonal Influenza, COVID-19, and Respiratory Virus Vaccines Timely monitoring of the effectiveness of influenza and COVID-19 vaccines in prevention of outpatient visits for acute respiratory infection is critical information for vaccine recommendations and preparation of new vaccines. We propose a platform for the monitoring of effectiveness overall, coupled with genomic data that will provide estimates for effectiveness against specific variants and strains.

PI_NAMEs: MARTIN, EMILY TOTH (contact)

PROJECT_TITLE: RFA-IP-22-004:Michigan-Ford Initiative to Measure Vaccine Effectiveness (MFIVE): Seasonal Influenza, COVID-19 and Respiratory Virus Vaccines


ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE – Duke Human Vaccine Institute Influenza, SARS-CoV-2 and other viral respiratory pathogens lead to tens of millions of infections on an annual basis resulting in burdens on population health, healthcare, hospital systems, and the U.S. economy. Vaccines to prevent influenza have been widely available for decades, while vaccines to prevent COVID-19 vaccine have recently been deployed to combat the ongoing SARS-CoV-2 pandemic. The Duke Human Vaccine Institute will provide coordination for the Centers for Disease Control and Prevention’s network designed to assess the effectiveness of respiratory virus vaccines, including both influenza and COVID-19 vaccines, at preventing symptomatic respiratory infection in the community setting.

PI_NAMEs: WALTER, EMMANUEL B (contact)

PROJECT_TITLE: RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings