ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE The noncoding genome has long been considered important to human health and disease, however, little direct evidence exists to support this claim. This project proposes to use a novel technology to systematically perturb noncoding genetic elements in vivo and at scale to assess their functions in animal development and behavior. The proposed work will be transformative and will result in a significant leap in our understanding of how the noncoding genome regulates various biological processes, dysregulation of which underpins many human diseases.

PI_NAMEs: PARVEZ, SABA  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Animal Model;Animals;Behavior;behavioral phenotyping;Biochemical;Bioinformatics;Biological Assay;Biological Process;blind;Brain;Budgets;career;Cell Culture Techniques;Cell Proliferation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Communities;comparative genomics;Complex;Conserved Sequence;cost;CRISPR/Cas technology;design;Development;Developmental Biology;Disease;Elements;Embryo;Embryonic Development;Enhancers;Ensure;epigenomics;Evaluation;Exclusion;Exons;Eye Development;Five-Year Plans;gene function;Genes;Genetic;genetic element;Genetic Screening;Genome;genome wide association study;genome-wide;Genomic Segment;Genomics;Growth;Guide RNA;Health;high throughput screening;high throughput technology;Human;human disease;Human Genome;Human Genome Project;Immunity;improved;In Vitro;in vivo;Infection;Injections;insight;Knock-out;knockout gene;Knowledge;Link;Malignant Neoplasms;Mammalian Cell;meetings;Mentors;Mentorship;Modeling;molecular phenotype;Molecular Profiling;monolayer;mutant;Neoplasm Metastasis;Neurodevelopmental Disorder;neuropsychiatric disorder;new technology;novel;Organoids;Phase;Phenotype;Physiology;Poison;promoter;Research;Research Project Grants;Research Training;reverse genetics;Role;scale up;Science;single-cell RNA sequencing;skill acquisition;System;Technology;Time;tool;Training;training opportunity;Transcript;Untranslated RNA;vertebrate genome;Vision;Work;Zebrafish

PROJECT_TITLE: In vivo functional screen of noncoding genetic elements

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: NARRATIVE We propose to construct the Myeloma Multidimensional Pre-Cancer Atlas (MMPCA); as multiple myeloma (MM) is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM), with a transformation rate of ~1% and ~10% per year, respectively. Large racial disparities exist in MM and its premalignant conditions; compared to Whites, African-Americans have a two- fold increased prevalence of MGUS/MM and are diagnosed with MM at younger ages. We will leverage our large collection of samples from two cohort studies that are racially diverse to create a comprehensive spatial and temporal atlas of precursor MM to understand genomic and microenvironmental alterations across the spectrum of disease evolution from healthy to MM.

PI_NAMEs: GHOBRIAL, IRENE M. (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: African;African American;African American population;African ancestry;Age;Atlases;B lymphoid malignancy;B-Lymphocytes;Biological;Biopsy;Blood;Bone Marrow;burden of illness;Cell Communication;Cells;Clinical;Clonal Expansion;cohort;Cohort Studies;Cytometry;Data;Detection;Diagnosis;Dimensions;Disease;disease model;Disease Progression;Early Intervention;Environment;Event;Evolution;Excision;Family history of;follow-up;General Population;Genetic;genome sequencing;Genomics;Germ Lines;Hematologic Neoplasms;Hematology;high risk;Image;Immune;In Situ;Individual;Lesion;Longterm Follow-up;Malignant - descriptor;Malignant Neoplasms;Maps;Marrow;Monitor;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;Operative Surgical Procedures;Organ;Participant;Patients;Persons;Plasma Cells;Population;Population Heterogeneity;Precancerous Conditions;Predisposition;premalignant;Prevalence;progression risk;racial disparity;racial diversity;Resources;Risk;Role;sample collection;Sampling;single-cell RNA sequencing;Solid;Stromal Cells;Structure;Technology;Testing;Therapeutic Intervention;Tissues;transcriptome sequencing;transcriptomics;Trephine Biopsy;whole genome

PROJECT_TITLE: Myeloma multidimensional precancer atlas

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M3)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Dendritic cells (DCs) have been implicated as the critical mediator of the demonstrated efficacy of lipid nanoparticle (LNP)-based COVID-19 vaccines but the exact molecular and cellular mechanisms of LNP immunogenicity in DCs remain unclear. The outlined proposal seeks a) to elucidate such mechanisms by characterizing changes in transcriptional program, phenotype and function of dendritic cells (DCs) upon LNP uptake and payload expression of LNPs and b) to devise bi-specific antibody-based strategies to improve DC- targeting in vivo. In achieving the aims of the proposal, we hope to pave the way forward to more rational designs of LNP formulations as well as enhanced targeting strategies to modulate DCs to enhance anti-tumor immunity.

PI_NAMEs: MOON, CHANG YOON (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 2019-nCoV;Adjuvanticity;Antibodies;Antigen-Presenting Cells;antitumor effect;Attention;Binding;Bispecific Antibodies;Bone Marrow;cancer immunotherapeutics;cancer immunotherapy;career;Cell Compartmentation;cell type;Cells;clinical efficacy;Clinical Trials;Coculture Techniques;Complex;Consensus;COVID-19 vaccine;Dendritic cell activation;Dendritic Cells;Development;Disease;Dose;Engineering;Formulation;Foundations;Gene Expression Profile;Genetic Transcription;Immune;Immune response;Immune system;Immune Targeting;Immunity;immunogenic;immunogenicity;immunoregulation;improved;In Vitro;in vivo;Inflammatory;innovation;Interleukin-12;Knockout Mice;Lipid Chemistry;lipid mediator;lipid nanoparticle;Lipids;Lung;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Methods;Molecular;mouse model;mRNA lipid nano particle vaccine;multidisciplinary;Mus;Myelogenous;Nature;novel;Outcome;Pattern recognition receptor;Phenotype;programs;Proteins;rational design;Receptor Signaling;Reporting;Research;Resolution;response;single-cell RNA sequencing;Sorting;success;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic gene;Tissues;Training;transcriptome sequencing;Transfection;tumor;Tumor Immunity;uptake

PROJECT_TITLE: Characterizing DC-specific mechanisms of LNP immunogenicity to enhance LNP-based anti-tumor therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: This proposal will detail my progress and future plans to examine the function of meiotic histone reader ZCWPW1 in ovarian reserve formation, genomic fidelity, and oocyte quality. Through this work, I hope to identify the keystone factors that regulate oocyte quality and characterize their impact on ovarian physiology and fertility. This proposal has applications to our understanding of human infertility, early embryonic miscarriages, and primary ovarian insufficiency.

PI_NAMEs: BAZZANO, DOMINIC  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Adolescent;advanced maternal age;Age;Age Months;aged;Alleles;Aneuploidy;Animals;Biology;Cell division;Cell Nucleus;Chromatin;chromatin modification;Chromosome abnormality;Chromosome Pairing;Chromosomes;Complement;Cytology;Data;daughter cell;Defect;diminished ovarian reserve;Disease;DNA;DNA Binding Domain;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Embryo;Event;Evolution;experimental study;Failure;Female;Fertility;Filament;Frequencies;Future;Gametogenesis;Genetic Crossing Over;genetic information;Genetic Models;Genetic Recombination;Genetic Variation;genomic locus;Genomics;Germ Cells;Haploidy;Histone H3;Histones;Homologous Gene;homologous recombination;Human;Hybrids;Infertility;insight;Kinetics;Life;Link;loss of function;Lysine;Maintenance;male;Male Sterility;Mammals;Mediating;Meiosis;Meiotic Prophase I;Meiotic Recombination;Metaphase;Methylation;Methyltransferase;MLH1 gene;Modeling;Modification;Molecular;Monitor;mouse model;Mus;mutant;Mutant Strains Mice;novel;Nucleosomes;oocyte quality;Oocytes;Outcome;Ovarian;ovarian reserve;Pathway interactions;Perinatal;Phenotype;Physiology;postnatal;Premature Ovarian Failure;prenatal;primary ovarian insufficiency;Process;Prophase;Proteins;Quality Control;Reader;recruit;reproductive fitness;Resolution;Role;Series;sexual dimorphism;Signal Transduction;Site;Specific qualifier value;Spermatocytes;SPO11 gene;Spontaneous abortion;Sterility;Synapses;Techniques;Testing;Work;Zinc Fingers

PROJECT_TITLE: Dissecting the role of ZCWPW1 in oocyte quality, fertility and ovarian physiology.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STONY BROOK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The most functionally important features of protein molecules are their atomic structure and the dynamics of how that structure moves. This project will directly address two major barriers to progress of biomedical research by (1) enabling investigation of protein structure not just in the test tube but in the native living environment and (2) revealing dynamics of much larger proteins than is currently feasible. Successful completion will advance a plethora of biomedical research and development efforts, most immediately the design of new antibiotics for bacterial pathogens.

PI_NAMEs: SEREBRYANY, EVGENY  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Advisory Committees;Affect;Affinity Chromatography;Algorithmic Analysis;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Aprotinin;Area;Award;Bar Codes;Biological Assay;Biomedical Research;Biophysics;Boston;career;career development;Cells;Chemicals;Chemistry;Chromosomes;Communities;community building;Computational algorithm;Computer Models;conformer;course development;Cytolysis;Data;Data Analyses;design;Development;dimer;Disease;disulfide bond;Disulfides;Educational process of instructing;Educational workshop;Environment;Escherichia coli;Evolution;experience;experimental study;fitness;Fluorescence Resonance Energy Transfer;Frequencies;Future;Future Teacher;Gene Library;Genotype;Goals;Head;improved;In Vitro;in vivo;Institution;Investigation;Ions;Kinetics;Knowledge;Lasers;Libraries;Light;Location;Maps;Mass Spectrum Analysis;Medical;member;Mentors;Mentorship;Methods;Microbial Physiology;Molecular;Molecular Chaperones;Molecular Conformation;monomer;next generation;non-Native;novel therapeutics;oxidation;Oxidation-Reduction;Pathogenesis;pathogenic bacteria;Pathway interactions;Penicillin-Binding Proteins;Peptide Sequence Determination;Peptides;Peptidyltransferase;periplasm;Pharmaceutical Preparations;Phase;Phenotype;Physics;Physiologic pulse;Point Mutation;Positioning Attribute;Productivity;protein complex;Protein Conformation;Protein Dynamics;protein structure;Proteins;Publications;recruit;Research;research and development;Research Project Summaries;resistance mutation;responsible research conduct;Ribonucleases;Role;Scanning;Seminal;single molecule;single-molecule FRET;Site;Slide;Source;Spottings;Staphylococcus aureus;structural biology;Structure;Sulfhydryl Compounds;Technical Expertise;Techniques;Technology;Testing;Time;tool;Training;Tube;undergraduate student;Universities;Variant;Work

PROJECT_TITLE: High-throughput disulfide and FRET scanning to reveal protein conformational ensembles in vitro and in vivo.


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Secretion of saliva is tightly regulated, as it is critical for ease of everyday tasks such as speaking, digestion, and maintaining oral health. While autonomic neuronal control of the major salivary glands has been well described, the role of direct trigeminal sensory innervation of the glands has not been explored. The proposed research will explore the function of Trp-positive trigeminal sensory neurons innervating the submandibular salivary glands, providing a foundation for new therapeutic targets for those affected with salivary issues such as Sjogren’s disease (i.e., autoimmune disease that attacks the salivary and lacrimal glands) and xerostomia (i.e., dry mouth).

PI_NAMEs: CANNIZZARO, DEANNA NICOLE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acidity;Acute;Address;Affect;Afferent Neurons;American;Autoimmune Diseases;Base Composition;Brain;Brain Stem;C10;calcium indicator;Cell Nucleus;cellular targeting;Chemical Stimulation;Chemicals;Classification;comparative;comparison control;craniofacial tissue;Cre driver;Cues;Data;designer receptors exclusively activated by designer drugs;Detection;Diagnostic;Digestion;Disease;Duct (organ) structure;experimental study;falls;Feedback;Foundations;Functional disorder;Genes;Genetic;Gland;Goals;Head;Image;Immunohistochemistry;In Situ Hybridization;in vivo calcium imaging;Infection prevention;irradiation;Label;Lacrimal gland structure;Link;Liquid substance;Major salivary gland structure;Mammals;Mediating;Methods;Molecular;molecular targeted therapies;Mouse Strains;Mus;nerve supply;neuronal cell body;Neurons;new therapeutic target;novel;Oral;Oral cavity;Oral health;oral tissue;Osmolar Concentration;Output;Pain;Parasympathetic Nervous System;Parotid Gland;Patients;Periodontal Ligament;Peripheral;Physiological;Play;Production;Proteins;Protons;Quality of life;receptor;Reflex action;Regulation;Reporter;Research;response;Role;Saliva;saliva composition;saliva sample;saliva secretion;Salivary;Salivary Glands;Sensory;sensory feedback;side effect;single cell sequencing;Sjogren's Syndrome;somatosensory;Stains;Structure;Structure of trigeminal ganglion;Sublingual Gland;Submandibular gland;Sympathetic Nervous System;System;Temperature;therapeutic target;Time;Tissues;Tooth Demineralization;Touch sensation;transcriptomics;transmission process;Trigeminal System;TRP channel;Viral Vector;Viscosity;Xerostomia

PROJECT_TITLE: Determining the function of Trp-positive trigeminal sensory neurons innervating the submandibular salivary glands

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE (Award Period 03/01/2023-02/29/2024) The University of Rochester and Wilmot Cancer Institute has a long-standing history of conducting clinical research through the NCI’s National Clinical Trials Network. Our commitment to clinical trials and the impact they have on clinical care is evidenced by our increasing accrual rates leading to recognition as a High Performance Site and expanded involvement of Wilmot investigators within the NCTN. This award will continue to support our research activities, develop impactful clinical trials, mentor the new researchers, and provide cutting edge treatment options for patients.

PI_NAMEs: BARR, PAUL M (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adult;Award;base;Cancer Biology;cancer clinical trial;Clinical;clinical care;Clinical Research;Clinical Trials;community based practice;community partners;Complex;Correlative Study;data management;Dedications;Development;Disease;Eastern Cooperative Oncology Group;Enrollment;Funding;gastrointestinal;Genitourinary system;Goals;Gynecologic Oncology;Health;Hematology;improved;improved outcome;Institution;Investments;Laboratory Research;Lead;Leadership;leukemia;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Marketing;Medical Oncology;member;Mentors;multidisciplinary;Multiple Myeloma;National Clinical Trials Network;novel therapeutic intervention;Oncology;oncology program;participant enrollment;Patients;performance site;Persons;Phase;Prevention;programs;Radiation Oncology;rare cancer;Rare Diseases;Recording of previous events;Research Activity;Research Institute;Research Personnel;Site;Southwest Oncology Group;success;Surgical Oncology;therapy outcome;Time;Tissue Banks;Underrepresented Populations;Universities

PROJECT_TITLE: Rochester Network Lead Academic Participating Site


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The proposed research is relevant to public health because it will enable the identification of pathogenic repeat expansions in human disease, leading to a new class of precision-targeted therapeutics. The proposed research is relevant to NHGRI because new genomic tools are urgently needed to identify these repeat expansions.

PI_NAMEs: ERWIN, GRAHAM SCOTT (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Affect;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biology;career;Catalogs;Cell Physiology;Cell Survival;Chemicals;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Copy Number Polymorphism;Darkness;Data;Data Set;Detection;Development;Disease;DNA;DNA Sequence;DNA sequencing;Environment;experience;Failure;FDA approved;Fragile X Syndrome;Frequencies;functional genomics;Funding;Gene Expression;Gene Expression Regulation;Genetic Diseases;Genetic Variation;Genome;genome-wide;genomic data;genomic tools;Goals;human disease;Human Genetics;Human Genome;improved;Introns;Malignant Neoplasms;Maps;Mendelian disorder;Mental disorders;Methods;Molecular Biology;Myotonic Dystrophy;National Human Genome Research Institute;Nucleic Acid Regulatory Sequences;Oncogenes;Outcome;Pathogenicity;Phase;Public Health;Publishing;Recurrence;Renal Cell Carcinoma;Research;Research Personnel;response;Role;Sampling;Science;Sensitivity and Specificity;Structure;Tandem Repeat Sequences;targeted treatment;Testing;The Cancer Genome Atlas;tool;Training;UGT2B7 UDP-glucuronosyltransferase;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Development and application of new tools to identify repeat expansions in human diseases


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed Society for Cardiovascular Magnetic Resonance (SCMR) Mid-Year Workshop will provide a vital platform for scientists and clinicians to optimize the use of cardiovascular magnetic resonance (CMR) in the treatment of heart failure (HF). Funding support from NHLBI will reduce financial barriers for trainees and early career investigators and underrepresented minority (URM) investigators to attend this workshop. The active involvement of students and early-career scientists and clinicians and URM investigators has the potential to achieve key objectives crucial for the ongoing advancement of medical imaging and cardiovascular medicine.

PI_NAMEs: KIM, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Adult;Area;Artificial Intelligence;Award;Biology;Biomedical Engineering;Blood flow;Cardiac;Cardiology;Cardiovascular system;career;Chicago;Child;Child Care;Clinical;clinical application;clinical practice;computer science;cost;Data Analyses;Dedications;Development;Diagnosis;Diagnostic;Diagnostic tests;Education;Educational Activities;Educational workshop;extracellular;Faculty Workshop;Female;Fertilization;Fostering;Funding;Future;Gadolinium;Goals;Guidelines;Heart Diseases;Heart failure;Hematological Disease;Image;Imaging Device;Industry;innovation;insight;Institution;interest;International;Knowledge;Leadership;lectures;Magnetic Resonance;Maps;Mathematics;Medical Imaging;Medicine;meetings;Mentorship;minority investigator;minority trainee;Mission;Multi-Institutional Clinical Trial;Myocardial;National Heart, Lung, and Blood Institute;Oncology;Oral;Participant;patient engagement;Patients;Phenotype;Physicians;Physics;Postdoctoral Fellow;posters;Precision therapeutics;Prevention education;prognostic;Protocols documentation;Radiology Specialty;Research;Research Infrastructure;Research Personnel;Resources;risk prediction;Role;Scanning;Scientist;Secure;Services;Societies;Students;supportive environment;Techniques;Technology;Testing;Time;Training;Translational Research;Translations;Travel;Underrepresented Minority;United States;Update;Work

PROJECT_TITLE: SCMR Mid-Year Meeting Chicago: CMR Phenotyping the Heterogeneic Expression of Heart Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE: Pre-saccadic attention has been related to enhanced neural responses before saccades and while several visual areas (V1, V4, and MT) have shown pre-saccadic enhancements in firing and neural sensitivity, much remains unknown about the underlying neural pathway. This fellowship proposal aims to tests if FEF drives pre-saccadic enhancement through feedback pathways to superficial and deep layers in extra-striate visual cortex, specifically in visual areas MT/MTC. Completing the aims of this proposal will provide greater insight into the circuitry controlling pre-saccadic enhancements.

PI_NAMEs: BUCKLAEW, AMY BEATRICE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Affective;Architecture;Area;area MT;Attention;Behavior;Behavior Control;Behavioral;Callithrix;career;cell type;Cells;Code;Cognitive;Computer Analysis;covert attention;Data;Development;Exhibits;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;Feedback;Fellowship;fovea centralis;Future;Human;Impairment;improved;indexing;inhibitory neuron;insight;interest;Lasers;Lesion;Light;Macaca;Maps;Measures;microstimulation;Modeling;Monkeys;Motion;Motor;neural;Neural Pathways;Neurons;novel;oculomotor;optogenetics;Pathway interactions;Pattern;Peripheral;Physiologic pulse;Population;Positioning Attribute;promoter;receptive field;Research Personnel;response;Role;Saccades;sample fixation;Sensory;Signal Transduction;Smooth Pursuit;Stimulus;Surface;Techniques;Testing;Training;Viral;Virus;Visual;Visual attention;Visual Cortex;visual motor;Visual Perception;Work

PROJECT_TITLE: Investigating the distribution and timing of pre-saccadic modulation across cortical layers in MT and the influence of FEF signals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Genetics;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Deficits in chemosensory processing are associated with normal aging as well as numerous neurodegenerative disorders including Alzheimer’s Disease (AD). This proposal will investigate how taste processing and taste memory are affected by aging and AD. A functional investigation into the mechanisms regulating age- and AD- associated decline in taste and memory will further our understanding chemosensory processing, aging, and neurodegenerative disease.

PI_NAMEs: BROWN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Afferent Neurons;Age;age effect;age related;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-42;Amyloid beta-Protein;Behavioral;Brain region;cell type;Cells;Cyclic AMP;Data;Detection;Deterioration;Drosophila genus;Drosophila melanogaster;Esthesia;experimental study;fly;Functional disorder;Functional Imaging;gene interaction;Genes;Genetic;genetic manipulation;genome-wide;Genomic approach;GTP-Binding Protein alpha Subunits, Gs;healthy aging;Human;hyperphosphorylated tau;Image;Impairment;in vivo;insight;Investigation;knock-down;Libraries;Measures;Mediating;Memory;Memory impairment;Mentors;Modeling;Molecular;Mushroom Bodies;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;normal aging;novel;pathological aging;Pathology;Pathway interactions;Phase;Phenocopy;Physiological;Physiology;Process;Protein Isoforms;response;RNA Interference;RNA interference screen;screening;sensor;Sensory;Signal Pathway;Signal Transduction;Structure;Study models;sugar;Synapses;Taste Perception;taste system;tau Proteins;Tauopathies;Testing;Toxic effect;Training;transcriptome sequencing;Transgenes;Variant

PROJECT_TITLE: The neural basis for aging-dependent decline in taste function


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE  This administrative supplement for the Early-stage Surgeon Scientist Program supports a female pediatric surgeon-scientist who is well-positioned to achieve scientific independence with the detailed career plan laid out in this application. The proposed study will provide fundamental knowledge about the effect of PIM kinases on lipid metabolism and differentiation in neuroblastoma and about lipid metabolism in neuroblastoma cancer stem cells. This information may uncover aspects of lipid metabolism that are able to be targeted in combination with other therapies to better treat children with neuroblastoma.

PI_NAMEs: SLECKMAN, BARRY P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;Affect;Animals;Basic Science;Benign;Biological Assay;Biology;Brain;cancer cell;Cancer Center Support Grant;cancer stem cell;career;Cell Line;Cells;Cellular Metabolic Process;Characteristics;Child;Childhood;Childhood Extracranial Solid Tumor;Childhood Solid Neoplasm;Clinical;Comprehensive Cancer Center;Coupled;Diagnosis;Differentiated Gene;Differentiation Antigens;Differentiation Therapy;Disease;disorder risk;Disparate;Drug resistance;Evaluation;Exhibits;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Female;Gene Expression Regulation;Genes;Goals;high risk;Image;in vivo;integration site;interest;Knowledge;Link;lipid metabolism;lipidomics;Lipids;Lipolysis;Maintenance Therapy;Malignant Neoplasms;metabolic phenotype;Metabolism;metabolomics;Methods;Mitochondria;Molecular;Morbidity - disease rate;Morphology;Murine leukemia virus;Mus;MYCN gene;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;neuroblastoma cell;Neurons;new therapeutic target;novel therapeutics;patient derived xenograft model;Patients;Phenotype;Phosphotransferases;PIM1 gene;Positioning Attribute;Process;Prognosis;programs;Property;proto-oncogene protein pim;Recurrence;Recurrent disease;Relapse;Research;response;Risk;Scientist;self-renewal;Serum;Shotguns;Sorting;stable isotope;Staging System;stemness;Surgeon;Survival Rate;Survivors;Testing;Tracer;Treatment Protocols;Tretinoin;tumor;tumor growth;tumor initiation;Undifferentiated;Up-Regulation;uptake;Work

PROJECT_TITLE: Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Patient Safety;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Chronic pain is both a leading cause of disability and the primary reason for seeking out medical attention in the US, making it a significant socioeconomic burden on healthcare systems, particularly given the rapidly aging population. Recent evidence suggests that acupuncture is an appropriate and effective long-term non- pharmacological treatment for chronic pain; however, there are large gaps in our understanding of how acupuncture may be streamlined and integrated equitably into the American healthcare system. This proposal uses ethnographic, implementation science, and health equity approaches to better understand pain management plans that include acupuncture, identify gaps in continuity of care within integrated pain management plans for older adults, and evaluate randomized controlled trial study designs to advance this area of research forward.

PI_NAMEs: DING, JESSICA LU (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Acupuncture Therapy;Address;Adoption;Adult;adverse event risk;Age;Aging;aging population;American;American College of Physicians;Area;Biological Markers;California;Caring;Case Series;Chinese;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;Clinical Practice Guideline;Clinical Trials;cohort;Community Hospitals;Continuity of Patient Care;cost;Counseling;Data;disability;Dissemination and Implementation;Documentation;Economic Burden;Effectiveness of Interventions;Electronic Health Record;electronic health record system;Epidemic;Equity;ethnographic method;Ethnography;evidence base;experience;Future;Goals;Health;health care delivery;health care service;health equity;health record;Healthcare;healthcare burden;Healthcare Systems;Hospitals;human old age (65+);Immigrant;implementation science;implementation strategy;improved;Individual;innovation;Inpatients;Institution;Integrated Health Care Systems;Integrative Medicine;interest;Interview;Knowledge;Language;lens;Mainstreaming;Managed Care;Maps;Medical;medical attention;Metabolism;Mission;Modeling;Molds;Monitor;multidisciplinary;National Health Interview Survey;Neuroanatomy;Nonpharmacologic Therapy;older adult;opioid overdose;Outcome Measure;Outcomes Research;Pain;Pain management;patient population;patient safety;Patient-Focused Outcomes;Patients;payment;Pharmaceutical Preparations;pharmacologic;Physicians;Play;Population;Prevalence;Process;prospective;Provider;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Research Proposals;research study;Risk;San Francisco;Serum;Service delivery model;Services;Shapes;skills;social health determinants;socioeconomics;stakeholder perspectives;Structure;System;Systems Integration;Training;underserved community;United States;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Addressing Chronic Pain in Older Adult Populations: Acupuncture Healthcare Delivery Model Innovation in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE (Relevance Statement): We have developed the largest fully integrated database that is shared with researchers around the world to help identify promoter–enhancer interactions (PEIs) that contribute to complex patterns of gene expression in the retina. Using this database, we identified evolutionarily conserved enhancers for each of the early retinal transcription factor network genes that regulate developmental stage– and cell type–specific gene expression. Discoveries from this study will advance our understanding of complex gene regulation mechanisms that are directly relevant to human retinopathies and bridge a fundamental gap in our knowledge about gene regulation in retinal development and disease.

PI_NAMEs: DYER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Address;Affect;Amacrine Cells;ATAC-seq;Binding;Binding Sites;Biomedical Research;Birth Order;Brain;cell fate specification;cell type;Cells;Chromatin;Chromatin Structure;Communities;Complex;Data;data integration;data sharing;Databases;Defect;Development;Disease;Elements;Enhancers;Ensure;Evaluation;Eye Development;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;gene network;Genes;Genetic Engineering;Genome;genome-wide;Government;Health;Human;human disease;human embryonic stem cell;Individual;knockout gene;Knowledge;Location;malformation;Maps;Molecular;Molecular Conformation;Mus;Mutation;Nucleic Acid Regulatory Sequences;Organoids;Pattern;Persons;Phenocopy;Play;Process;Proliferating;promoter;Publishing;Regulation;Regulatory Element;Research Personnel;Research Proposals;Retina;Retinal Diseases;retinal progenitor cell;retinogenesis;Role;Saint Jude Children's Research Hospital;single cell ATAC-seq;single-cell RNA sequencing;Spinal Cord;Structure;Testing;Thalamic structure;Time;transcription factor;Untranslated RNA;Update;Vision;Vision research;Work

PROJECT_TITLE: The Role of Modular Super-Enhancers in the Developing Murine and Human Retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-F (02)]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Cardiomyocyte calcium dysregulation is a well-established contributor to cardiovascular disease, yet few advances have been made in understanding the mechanisms underlying this dysregulation. The experiments proposed in this application aim to define the role of a novel microprotein, ALN, in cardiomyocyte calcium regulation in health and disease. The successful completion of this work will expand our current knowledge of calcium handling in the heart and contribute to the long-term goal of developing new therapeutics aimed at restoring cardiomyocyte calcium homeostasis to alleviate the major health burden of heart disease.

PI_NAMEs: HASSEL, KEIRA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Active Biological Transport;Adrenergic Agents;Adult;Affect;Affinity;Agonist;Alanine;Angiotensin II;Area;base;Binding;Body System;Ca(2+)-Transporting ATPase;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Caring;cell type;Cells;Chronic;Co-Immunoprecipitations;Coupled;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Defect;Development;Disease;Disease Progression;Dissociation;doctoral student;Endoplasmic Reticulum;Endothelin;Endothelin-1;Event;experience;experimental study;Felis catus;Functional disorder;G alpha q Protein;G-Protein-Coupled Receptors;gain of function;gene delivery system;Goals;GTP-Binding Protein alpha Subunits, Gs;Health;Heart;Heart Contractilities;Heart Diseases;Homeostasis;In Vitro;in vivo;insight;Isoproterenol;Knock-out;Knockout Mice;Knowledge;Laboratories;loss of function;Measures;Mediating;Medical center;mimetics;Morbidity - disease rate;mortality;Mus;Muscle Cells;Mutate;Neonatal;Neurosecretory Systems;novel;novel therapeutics;Pathway interactions;Pediatric Hospitals;Phenylephrine;phospholamban;Phosphorylation;Physiology;Positioning Attribute;prevent;Prevention;Proteins;Rattus;receptor;Receptor Signaling;Regulation;Relaxation;Research;response;Role;Sarcoplasmic Reticulum;Sequence Homology;Serine;Signal Induction;Signal Pathway;Signal Transduction;Stimulus;Testing;therapeutic target;Tissues;Ventricular;Work

PROJECT_TITLE: Determining the regulatory role of microprotein ALN on SERCA2a and heart contractility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research will elucidate fundamental mechanisms that ensure the faithful inheritance of chromosomes during meiosis, the specialized cell division program that produces sperm and eggs. Errors in the inheritance of chromosomes are the primary known cause of miscarriage and birth defects and are also a major factor contributing to the development and progression of many cancers, making the study of meiosis informative for human health at multiple levels. My approach will focus on a newly discovered component of the meiotic machinery that provides an exceptional opportunity to investigate the formation and regulation of meiotic crossovers, which are needed to direct faithful chromosome segregation during meiosis.

PI_NAMEs: UEBEL, CELJA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Aneuploidy;Architecture;Binding;Biological Assay;Caenorhabditis elegans;Cell division;Cells;Charge;Chromosome Arm;chromosome missegregation;Chromosome Pairing;Chromosome Segregation;Chromosome Structures;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Congenital Abnormality;Cytology;Data;Development;Diploidy;Disease;DNA;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;egg;Ensure;Equilibrium;Exhibits;experimental study;Failure;Gene Modified;Genetic;Genetic Crossing Over;Genetic Recombination;Genetic Screening;Genome;genome integrity;Germ Cells;Haploidy;Health;Homologous Gene;Human;innovation;insight;Investigation;Label;Malignant Neoplasms;Meiosis;Methodology;microscopic imaging;Modeling;Names;Organism;Process;programs;protein degradation;protein protein interaction;Proteins;recruit;Regulation;repaired;Reproduction;Research;Risk;Role;scaffold;segregation;Series;Sexual Reproduction;Site;sperm cell;Spontaneous abortion;superresolution microscopy;System;Testing

PROJECT_TITLE: Formation and Regulation of Meiotic Crossovers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BRONX

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative There is some evidence that World Trade Center (WTC) rescue/recovery workers considered to have high- level WTC dust exposure have a greater risk of cardiovascular disease (CVD) events compared with workers with lower exposure. Inconsistencies in prior WTC CVD study results could be due to the use of different definitions for WTC exposure and for CVD. The goal of the current proposal is to clarify whether WTC exposure leads to an increase in risk of CVD events in rescue/recovery workers and to evaluate the temporal pattern of post-9/11 CVD incidence, using a large unified cohort of 69,100 WTC-exposed rescue/recovery workers, harmonized exposure definitions, and consistent outcome definitions.

PI_NAMEs: ZEIG-OWENS, RACHEL  (contact)

PROGRAM_OFFICER_NAME: YIIN, JAMES

PROJECT_TITLE: Cardiovascular Disease among WTC-exposed Rescue/Recovery Workers

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 LEE (52)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE There are a half-million open heart surgeries annually in the United States, and roughly 165,000 of these patients will develop postoperative atrial fibrillation (poAF). As the risk of chronic AF is eight-fold greater in poAF patients, developing safe and effective targeted therapies that work within the relevant timeframe would significantly reduce rates of chronic atrial fibrillation, which is the most common arrhythmia worldwide and a leading cause of ischemic stroke that currently has no disease-modifying therapies. Thus, this research is relevant to the NHLBI’s mission as it will enhance the health and lives of the many individuals who undergo cardiothoracic surgery by reducing the risk of poAF as well as future AF and stroke.

PI_NAMEs: KEEFE, JOSHUA ANTHONY (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adrenergic beta-Antagonists;Anti-Inflammatory Agents;Aorta;Arrhythmia;Atherosclerosis;Atrial Fibrillation;Automobile Driving;Binding;Calcium;calmodulin-dependent protein kinase II;Cardiac Myocytes;Cardiac Surgery procedures;Cardiovascular Diseases;cell type;Cells;Chronic;Closure by clamp;conditional knockout;Data;Dichloromethylene Diphosphonate;Disease;Drug Targeting;Exhibits;experimental study;FDA approved;Future;Generations;Genetic Transcription;Goals;Health;Heart Atrium;Heart failure;Hepatocyte;Hour;Human;IL6ST gene;Immunosuppression;Incidence;Individual;Infiltration;Inflammasome;Inflammation;Inflammation Mediators;inhibitor;Interleukin-6;interleukin-6 receptor alpha;Interleukins;Ischemic Stroke;Knockout Mice;Leukocytes;Liposomes;Lymphocyte;Macrophage;Mediating;Membrane;Methods;mimetics;Mission;Molecular;molecular targeted therapies;monocyte;mortality risk;mouse model;Mus;National Heart, Lung, and Blood Institute;Non-Steroidal Anti-Inflammatory Agents;novel;Open Reading Frames;Operative Surgical Procedures;Pathway interactions;Patients;Pericardiectomy;Perioperative;Phosphorylation;Postoperative Period;Prevention;Production;Prophylactic treatment;Proteins;Publishing;Recurrence;Reproducibility;Research;Risk;Risk Reduction;Ryanodine Receptor Calcium Release Channel;Secondary to;side effect;Signal Transduction;Sinus;STAT3 gene;Stroke;stroke risk;Symptoms;systemic inflammatory response;targeted treatment;Technology;Testing;therapeutic target;Tissues;Transactivation;Transgenic Mice;United States;Up-Regulation;Work

PROJECT_TITLE: Macrophage-mediated interleukin-6 signaling drives ryanodine receptor 2 calcium leak in postoperative atrial fibrillation


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Natural Products

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The World Health Organization and 2030 United Nations Agenda for Sustainable Development have urged research aimed at reducing cancer mortality rates. Plant peptide natural products with macrocyclizations, such as moroidins, are an important source of anticancer agents, but their synthetic production and diversification has been challenging due to complex macrocyclization chemistry. Metabolic engineering of moroidin biosynthesis in transgenic Nicotiana benthamiana will generate a small library of moroidin analogs for high- content screening and mechanistic elucidation in cancer cell lines.

PI_NAMEs: SHAFIQ, KHADIJA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Adenocarcinoma Cell;Anabolism;analog;anti-cancer treatment;Antineoplastic Agents;Biological Availability;Biological Products;C-terminal;Camptothecin;cancer cell;Cancer cell line;cancer therapy;Cell Line;Cell Membrane Permeability;Chemical Structure;Chemicals;Chemistry;Cloning;Complex;Copper;crosslink;Cyclic Peptides;Cyclization;cytotoxic;cytotoxicity;Death Rate;Development;Disease remission;Dose;drug development;drug discovery;Drug resistance;Engineering;Exhibits;expression vector;FDA approved;Fluorescent Probes;Genes;Goals;high throughput screening;Histidine;Human;improved;Infiltration;insight;Japanese;Label;Leucine;Libraries;liquid chromatography mass spectrometry;Lung Adenocarcinoma;Machine Learning;Malignant Neoplasms;Measurement;Metabolic;metabolic engineering;Metabolism;Modification;mortality;mutant;N-terminal;Natural product discovery;Natural Products;Nicotiana;novel;Oral;Organic Synthesis;Paclitaxel;Pathway interactions;peptide analog;Peptide Library;peptide natural products;Peptides;Periodicity;Pharmaceutical Preparations;Phenotype;Plant Model;Plant natural product;Plant Sources;Plants;Production;Pyroglutamate;rational design;Reaction;Research;Resistance;response;Rhizobium radiobacter;Ribosomes;Route;scaffold;Scoring Method;screening;Side;small molecule;Source;Specificity;Structure;Substrate Domain;Sustainable Development;Syringes;System;Testing;Time;Tobacco;Transgenic Organisms;treatment strategy;Tryptophan;United Nations;unsupervised learning;Validation;Work;World Health Organization

PROJECT_TITLE: Biosynthetic Development and Diversification of Moroidin Peptides for Cancer Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04A-V (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Staphylococcus aureus infections are a major public health concern due to their high prevalence and significant morbidity and mortality. This proposal will investigate a novel facet of S. aureus peptidoglycan processing that promotes recognition by the host immune system. It is anticipated these studies will aid in our understanding of how immune cells sense peptidoglycan and its relevance to host-pathogen interactions.

PI_NAMEs: JOHNSON, KAELIE RENEE (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Antibiotic Resistance;Antibiotics;Attenuated;Bone Marrow;CASP1 gene;Caspase;Cell Survival;Cell Wall;Cells;Cessation of life;Cleaved cell;clinically relevant;community setting;Complex;crosslink;cytokine;Cytosol;Data;Disaccharides;Ensure;Environment;Enzymes;Extracellular Space;Glucosaminidase;Grant;High Pressure Liquid Chromatography;High Prevalence;Hospitals;Hydrolase;Immune;Immune response;Immune system;Immunologics;immunopathology;in vivo;Infection;Infectious Skin Diseases;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interleukin-1 beta;Knowledge;Length;lipoteichoic acid;Literature;macromolecule;Macrophage;Mediating;Mediator;methicillin resistant Staphylococcus aureus;Microscopy;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutation;N-acetylmuramic acid;N-Acetylmuramoyl-L-alanine Amidase;Natural Immunity;Nature;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Pattern;Pattern recognition receptor;Peptide Hydrolases;Peptides;Peptidoglycan;Physiological;Polysaccharides;Preparation;Process;Production;Public Health;Reporting;Resistance;response;Role;Skin Tissue;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;stressor;Structure;Surveys;Systemic infection;Teichoic Acids;Thick;Time;Virulence

PROJECT_TITLE: Elucidating the Role of a Staphylococcus aureus Glucosaminidase in the Innate Immune Response.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE A fundamental feature of perception is the ability to recognize objects or object features despite changes in presentation, such as size, position, or context. By investigating the population and circuit mechanisms underlying how the cerebral cortex builds neural representations that are invariant to these manipulations, we will begin to untangle the basic biological mechanisms underlying perception. This proposal specifically aims to investigate how invariance is computed for motion encoding in visual cortex with the goal of elucidating fundamental principles of sensory information processing in the brain.

PI_NAMEs: GANNON, SARA MARIE (contact)

PROJECT_TERMS: Animals;Area;area striata;area V1;Back;Behavior;Behavioral Paradigm;Biological;Brain;Calcium;Callithrix;Cells;Cerebral cortex;Color;Complex;Data;design;discrimination task;Experimental Designs;experimental study;extrastriate visual cortex;Frequencies;Goals;Human;Image;Individual;information processing;Inherited;Investigation;Linear Models;Literature;Macaca;Measures;Modeling;Motion;Motion Perception;multiphoton imaging;Mus;neural;neuronal patterning;Neurons;nonhuman primate;object recognition;optogenetics;Pathway interactions;Pattern;pattern perception;Perception;Population;Positioning Attribute;preservation;Property;Publishing;Rodent;Sensory;Series;Signal Transduction;spatiotemporal;Stimulus;Stream;Testing;Training;two-photon;Variant;Visual;Visual Cortex;visual processing;Work

PROJECT_TITLE: Investigating invariant motion encoding in mouse visual cortex


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Respiratory viral infections and interstitial lung diseases are characterized by the large-scale expansion and migration of ectopic cells to alveoli, where they participate in a dysplastic form of remodeling, leading to long- term reduced lung function as well as increased mortality in cases of Idiopathic Pulmonary Fibrosis. The signals facilitating this dramatic proliferative/migratory event and whether these cells contribute to pulmonary fibrosis is unknown. This proposal will therefore investigate the role of NF-κB signaling in dysplastic remodeling and the pro-fibrotic function of these ectopic cells, thereby providing insight into the underlying mechanisms governing their migration and fibrotic pathology.

PI_NAMEs: HOLCOMB, NICOLAS PHILIP (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;airway epithelium;Alveolar;alveolar epithelium;Alveolus;Animals;Area;Basal Cell;Biological Assay;Cause of Death;Cell Line;cell motility;Cell Proliferation;Cells;Collagen;combat;conditional knockout;connective tissue growth factor;Coupled;cytokine;Data;Deposition;Diagnosis;Diffuse;Distal;Distant;Dysplasia;Environment;Epithelial Cells;epithelial stem cell;epithelial to mesenchymal transition;Epithelium;Event;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Functional Regeneration;Future;Gases;Growth Factor;Hydroxyproline;idiopathic pulmonary fibrosis;Image;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;Infection;Inflammation Mediators;Inflammatory;Influenza;Influenza A Virus, H1N1 Subtype;injured;Injury;insight;Interstitial Lung Diseases;Knock-out;Knockout Mice;Link;Lung;Lung Diseases;lung injury;Mediating;Mesenchymal;migration;mortality;Myofibroblast;Natural regeneration;novel strategies;overexpression;paracrine;Paracrine Communication;Pathology;Pathway interactions;Phenotype;Proliferating;Pulmonary Fibrosis;pulmonary function;Recovery;respiratory;Respiratory Disease;response;restoration;Risk;Role;Signal Pathway;Signal Transduction;Site;stem cells;Surface;Testing;therapeutic target;Tissues;TNF gene;TNFRSF5 gene;transcription factor;transcriptome sequencing;Up-Regulation;Viral;Viral Pneumonia;Viral Respiratory Tract Infection;Western Blotting

PROJECT_TITLE: Identifying Inflammatory Signals Facilitating Ectopic Krt5+ Cell Migration and their Function in the Alveoli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Despite the high prevalence of epilepsy in the United States, current anti-seizure medications are limited because a significant proportion of patients develop drug resistance and experience significant off-target side effects. This proposal will determine whether pathological neuronal expression of the SUR1-TRPM4 channel, a potential disease-specific therapeutic target I’ve previously found to upregulate in epileptic human and rodent brain, contributes to elevated seizure susceptibility in chronic epilepsy. Direct inhibition of SUR1-TRPM4 has high therapeutic potential, especially with the availability of an FDA-approved inhibitor glyburide, as an effective mechanism for seizure reduction in patients with epilepsy and other pathologies associated with seizures in which neuronal SUR1-TRPM4 expression has been characterized such as stroke, traumatic brain injury, neonatal hypoxia, and intracranial hemorrhage.

PI_NAMEs: MOYER, MITCHELL BRADLEY (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Anticonvulsants;Attenuated;Behavioral;Brain;brain tissue;burden of illness;Calcium;career;Cells;Central Nervous System;Cerebral hemisphere hemorrhage;Chronic;Clinical Research;Clinical Trials;comparison control;Confocal Microscopy;Coupled;Data;Data Analyses;Data Collection;defined contribution;Development;Disease;Drug resistance;drug resistance development;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;experience;experimental study;FDA approved;Fellowship;Frequencies;Funding;Genetic;Glyburide;Goals;High Prevalence;Hippocampus;Human;Hyperactivity;Hypoxia;hypoxia neonatorum;Image;Implant;improved;In Vitro;in vivo;inhibitor;Injections;Institution;Intracranial Hemorrhages;Ion Channel;Knock-out;Knockout Mice;Maryland;medical schools;Mission;Molecular;Molecular Target;Monitor;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuronal excitability;Neurons;Neurosurgeon;novel;overexpression;Pathologic;Pathology;Patients;Pentylenetetrazole;pharmacologic;Plasmids;Population;Positioning Attribute;preclinical study;Predisposition;prevent;Protein Overexpression;Proteins;Rattus;Research;Resected;response;Rodent;Rodent Model;Scientist;Seizures;sensor;side effect;Sodium;Sodium Channel;Status Epilepticus;Stimulus;Stroke;Techniques;Therapeutic;therapeutic target;Time;Tissues;Transfection;Translational Research;Traumatic Brain Injury;United States;Universities;Up-Regulation;vector;vector control;Viral;Wild Type Mouse;Work

PROJECT_TITLE: Pathological SUR1-TRPM4 Expression in Neurons Heightens Chronic Seizure Susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Our goal is to explore therapeutic modulation of heart ion pumps, with a focus on calcium and sodium pumps- crucial in heart function and established targets for heart failure treatment. We'll create innovative technologies to study drug effects on these pumps, driving drug discovery for these critical targets. This project aims to uncover structural insights into cardiac ion pump modulation and identify molecules for potential drug development.

PI_NAMEs: ESPINOZA-FONSECA, LENNANE MICHEL  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Artificial Intelligence;ATP phosphohydrolase;Automobile Driving;Binding;Binding Sites;Biological Assay;Ca(2+)-Transporting ATPase;Cardiac;Cardiac Glycosides;Cardiotoxicity;Cells;Clinical;clinically relevant;Congestive Heart Failure;Cryoelectron Microscopy;Crystallography;Data;Dose;Drug Design;drug development;drug discovery;experimental study;Goals;Heart;Heart failure;heart function;human induced pluripotent stem cells;Image;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;inhibitor;innovation;innovative technologies;insight;Ion Pumps;K ATPase;Kinetics;Lead;lead optimization;Machine Learning;Microscopy;Myocardium;Na(+)-K(+)-Exchanging ATPase;nanomolar;new therapeutic target;novel;Nucleotides;Outcome;Pathologic;Pharmaceutical Preparations;pharmacologic;phospholamban;Play;potency testing;protective effect;Pump;Rattus;Regulation;Relaxation;Research;Research Personnel;response;Roentgen Rays;Sarcoplasmic Reticulum;side effect;small molecule;small molecule inhibitor;Speed;structural biology;Structure;TAC1 gene;Therapeutic;Time;Treatment Failure;Ventricular;virtual screening

PROJECT_TITLE: Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumps

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: Project Narrative The majority of mammals rely on a placenta for in utero gas, nutrient and waste exchange. This organ must grow and vascularize to nourish an embryo whose metabolic demands it cannot directly sense, but the mechanisms underlying placental vascular development are poorly understood. The proposed studies will investigate the role of a cardio-placental BMP10-ENG/ALK1 endocrine signaling axis in instructing the formation of the placental labyrinth to improve our understanding of how this process is regulated.

PI_NAMEs: FRANKFURTER, MAXWELL T (contact)

PROJECT_TERMS: ACVRL1 gene;Affect;Affinity;allantois;angiogenesis;Arteriovenous malformation;Blood Vessels;BMP10 gene;bone morphogenetic protein receptor type I;Cardiac;Cardiac Myocytes;Cell Physiology;Circulation;Communication;Cone;congenital heart abnormality;Congenital Heart Defects;Data;Defect;Development;Disease;Embryo;Endocrine;Endoglin;Endothelial Cells;Endothelium;experimental study;fetal;Fetal Growth Retardation;Functional disorder;Gases;Genetic Transcription;Geometry;Goals;Growth;Heart;Hereditary hemorrhagic telangiectasia;Histologic;Human;Hypertension;Image;Impairment;improved;in utero;In Vitro;in vivo;Labyrinth;Ligands;Liver;Location;Mammals;Measures;Mediating;Metabolic;Molecular;Morbidity - disease rate;mouse genetics;Mus;mutant;Mutation;Nutrient;Nutritional Requirements;Organ;Oxygen;Pathology;Pathway interactions;Pattern;Perfusion;Phenocopy;Phenotype;Phosphorylation;Placenta;Placental Circulation;Placental Insufficiency;Placentation;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;Process;receptor;response;Role;Secondary to;Shapes;Side;Signal Transduction;single nucleus RNA-sequencing;Testing;TGFBR1 gene;Tissues;tool;transcriptomics;Transforming Growth Factor beta;Umbilical cord structure;vascular bed;Vascular Endothelial Cell;Vascularization;wasting

PROJECT_TITLE: Investigating a potential cardio-placental signaling axis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-J (20)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Services;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

PHR: NARRATIVE (OVERALL) The University of Michigan Rogel Cancer Center (Rogel) is committed to reducing cancer burden and improving cancer outcomes through research, innovation, transdisciplinary collaboration, education, and outreach. The Rogel vision is to be a leader in prevention, early diagnosis, optimal treatment and care for all at risk of or affected by cancer.

PI_NAMEs: FEARON, ERIC R. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Abbreviations;Advanced Malignant Neoplasm;Advisory Committees;Affect;Animal Model;anti-cancer research;Appointment;Basic Science;Biological Markers;Biological Sciences;Cancer Burden;Cancer Center;cancer clinical trial;Cancer Control;Cancer Detection;cancer education;cancer genetics;career;career development;Caring;Catchment Area;Cells;cellular imaging;Clinical;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Collaborations;college;Communities;community advisory board;community center;community engagement;Community Outreach;Comprehensive Cancer Center;Data Science;Development;Developmental Therapeutics Program;Direct Costs;Doctor of Philosophy;Drug Kinetics;Drug Screening;Early Diagnosis;Education;Engineering;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Faculty;Female;Financial Support;Flow Cytometry;Fostering;Funding;Gifts;Glossary;Grant;Growth;health communication;health equity;Health Policy;Hematopoiesis;Immunologic Monitoring;Immunology;improved;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;Investments;irradiation;Journals;Justice;Leadership;liquid biopsy;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;medical schools;Medicine;member;Michigan;Mission;molecular imaging;molecular pathology;Monitor;Names;National Cancer Institute;next generation;optimal treatments;Outcome;outreach;Patient Care;Patients;Population Sciences;pre-clinical;Prevention;Prevention program;programs;Proteomics;Public Health Schools;Publications;Publishing;Quality of life;Recording of previous events;recruit;Research;Resource Sharing;Resources;Risk;RNA;Role;Schools;Signal Transduction;Strategic Planning;Structure;Survivors;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translational Research;translational research program;Translations;tumor;tumor microenvironment;United States National Institutes of Health;Universities;University of Michigan Comprehensive Cancer Center;Vision;Work

PROJECT_TITLE: Discovery of circulating tumor RNA biomarkers for pancreatic cancer detection and monitoring


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project aims to leverage three advanced techniques in single-cell and spatial omics profiling to construct a comprehensive spatiotemporal molecular and cellular atlas of human lymphomas. Furthermore, it seeks to assess the utility of this tumor atlas in examining the progression of lymphomas and uncovering potential biomarkers, thereby constituting a profoundly valuable data resource for mechanistic discovery. The outcomes of this project are anticipated to significantly enhance our understanding of lymphomagenesis and treatment responses.

PI_NAMEs: FAN, RONG  (contact);HALENE, STEPHANIE ;MA, ZONGMING ;XU, MINA LUQING

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: age group;Architecture;Atlases;B-Cell Lymphomas;B-Lymphocytes;Biological;Biological Markers;Biology;Cell Communication;cell type;Cells;cellular imaging;Classification;Clinical;Clonal Evolution;Computational Biology;Computer Models;computerized data processing;Data;data resource;Data Science;Development;Diagnosis;Disease;Disease Progression;Epigenetic Process;epigenome;Ethnic Population;Event;Evolution;Extranodal;Follicular Lymphoma;Gender;Goals;Growth;Hematologic Neoplasms;Hematology;Hematopathology;Histopathology;Human;human data;humanized mouse;Image;Immune system;Immunoblastic Lymphadenopathy;Immunofluorescence Immunologic;Immunologic Surveillance;Indolent;Inflammatory;large cell Diffuse non-Hodgkin's lymphoma;Link;Location;Lymphoid Tissue;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Maps;Medicine;Methods;Modeling;Molecular;Motivation;mouse model;multidisciplinary;multimodality;mutant;Mutation;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Nodal;Organ;Outcome;Pathology;patient stratification;Phenotype;Physiological;Play;potential biomarker;prevent;Proteins;racial population;Resistance;Resistance development;Resources;response;single cell proteins;single nucleus RNA-sequencing;spatial integration;spatiotemporal;Specimen;statistics;synergism;T-Cell Lymphoma;T-Lymphocyte;Techniques;Technology;Testing;Tissue atlas;Tissue Banks;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;treatment response;treatment stratification;tumor;tumor microenvironment;Visualization

PROJECT_TITLE: Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M2)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

PHR: Project Narrative Heart failure is a leading cause of death worldwide, in part because the adult mammalian heart lacks the ability to regenerate after injury. Cardiomyocyte and endothelial cell interactions are known to regulate cardiac growth during development. This proposal aims to use cardiac organoids to model myovascular growth niches, with the goal of identifying endothelially secreted factors that can stimulate cardiomyocyte proliferation.

PI_NAMEs: PARKER, LAUREN ELIZABETH (contact)

PROJECT_TERMS: Acceleration;Acute;Adult;Ambystoma;Biological Assay;Biological Models;Blood Vessels;bone;Bone Marrow;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cause of Death;CDH5 gene;Cell Communication;Cell Cycle;Cell Proliferation;Cells;Chronic;combinatorial;Complex;Coupling;CRISPR-mediated transcriptional activation;crypt cell;curative treatments;Custom;Data Set;Development;Disease;Endothelial Cells;Endothelium;experimental study;Genetic;Genetic Models;Goals;Growth;Growth Factor;Guide RNA;Heart;Heart failure;Heart Injuries;Human;Human Engineering;human induced pluripotent stem cells;human model;human subject;human tissue;IGF2 gene;Image;Injury;injury recovery;intercellular communication;intestinal crypt;Intestines;Ischemia;KDR gene;Left Ventricular Mass;Length;live cell imaging;Liver;Mammals;Mediating;Mendelian randomization;Modeling;Mus;Myocardial;Myocardial Infarction;Natural regeneration;Neonatal;neonatal mice;neonatal period;new therapeutic target;novel therapeutics;Organism;Organoids;overexpression;Physiological;Proliferating;Protocols documentation;receptor;Recovery;regenerative;Reperfusion Injury;Reperfusion Therapy;Reporter;Reproducibility;response to injury;Role;self assembly;Signal Transduction;single-cell RNA sequencing;spatiotemporal;stem cell niche;Testing;tissue regeneration;Tissues;translational therapeutics;United States;Validation;Vascular Endothelial Growth Factors;VEGFA gene;Work;Zebrafish

PROJECT_TITLE: Self-assembling cardiac organoids to model myovascular interactions in human cardiac tissue regeneration


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative:  Motor learning is fundamental for humans to become proficient in daily activities and includes two fundamental components, motor adaptation and skill learning, which are both critical for learning new competencies in daily life and in rehabilitation. This study will use non-invasive brain stimulation to examine the neural mechanisms that underlie motor learning, including whether both components of learning are lateralized to the left brain-hemisphere. The information gained from this study should prove essential for the optimal translation of non-invasive brain stimulation techniques to motor learning in rehabilitation.

PI_NAMEs: SAINBURG, ROBERT L (contact);TUNIK, EUGENE

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;Air;Anodes;arm;Behavioral Paradigm;Brain;Competence;Computer software;Data;experimental study;Foundations;Hand;Hockey;Human;Inferior;Laboratories;Learning;Learning Skill;Left;Left cerebral hemisphere;Leisure Activities;Leisures;Lesion;Life;Lobule;Magnetic Resonance Imaging;Measures;Mediating;Memory;Motor;motor control;motor learning;Movement;neural;Neuroanatomy;neuromechanism;noninvasive brain stimulation;Parietal;Parietal Lobe;Patients;Phase;Physiologic pulse;prevent;primary outcome;Process;programs;Rehabilitation therapy;Research;Role;Rotation;Self Care;skills;Sports;Stroke;stroke patient;Techniques;Tennis;Testing;transcranial direct current stimulation;Transcranial magnetic stimulation;transfer learning;Translations;Upper limb movement;virtual;visual motor;Visual Motor Coordinations;Work

PROJECT_TITLE: Lateralization of posterior-parietal cortex contributions to motor learning

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Hematology;Lung;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The primary goals of the parent award HL 163085 are: to understand the mechanisms of accelerated structural degeneration of implantable biomaterials in pediatric and young adults by assessing the role of protein absorption on implanted biomaterials and to test mitigation strategies to extend the lifespan of these biomaterials in vitro, ex vivo, and in vivo by using juvenile and adult rat models. In this revision we address how systemic vs pulmonary circulation conditions (including the different blood biochemistry and hemodynamic conditions) is impacting the materials used for reconstructive heart surgery.

PI_NAMEs: FERRARI, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: absorption;Acceleration;Address;Adolescent;Adult;Affect;Albumins;Amino Acids;aortic valve;Aortic Valve Insufficiency;Arrhythmogenic Right Ventricular Dysplasia;Biochemistry;Biocompatible Materials;Biological;biomaterial compatibility;Birth;Blood;Blood flow;calcification;Cardiac;cardiac implant;Cardiac Surgery procedures;Cattle;Childhood;Circulation;congenital heart abnormality;Congenital Heart Defects;Crosslinker;Disease;Ebstein's Anomaly;extend lifespan;Family suidae;Fatigue;Glucose;glycation;Goals;Harvest;Heart;Heart Valves;hemodynamics;high risk;IACUC;Implant;In Vitro;in vivo;Incubated;Ischemia;juvenile animal;Knowledge;Laboratories;Left;Lesion;Life;Mechanical Stress;Mediating;Methodology;Mitral Valve;Mitral Valve Insufficiency;Modeling;novel;oxidation;Oxygen;parent grant;parent project;Parents;Patients;pericardial sac;Physical condensation;Physiologic pulse;pressure;Process;programs;Proteins;Protocols documentation;Publications;Pulmonary Circulation;pulmonary vascular disorder;Rattus;reconstruction;Reconstructive Surgical Procedures;Risk Factors;Role;septal defect;Sheep;Side;Stenosis;Structure of jugular vein;sugar;System;Testing;Tetralogy of Fallot;Thrombosis;Time;Transposition of Great Vessels;United States;Venous;young adult

PROJECT_TITLE: Revision to Mechanisms of accelerated calcification and structural degeneration of implantable biomaterials in pediatric cardiac surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-D (02)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is associated with particularly poor outcomes and chemotherapy has been the mainstay of TNBC treatment for many years. With the recent advent of immunotherapy, certain patients with TNBC have experienced improved outcomes, although most patients fail to respond initially or develop resistance due to an immunosuppressive tumor microenvironment. This proposal investigates a molecular mechanism by which TNBC cells induce immunosuppression in their tumor microenvironment, paving the way for future development of new immunotherapeutic approaches to improving outcomes for patients with this challenging cancer.

PI_NAMEs: LITTLE, JOHN WALTON (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Archives;BCL10 gene;Biological Process;Biological Response Modifiers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer cell;Cancer Etiology;cancer subtypes;career;Cells;chemotherapy;Classification;Clinical;clinical translation;Clinical Trials;Coculture Techniques;Complex;CRISPR/Cas technology;cytokine;Data;Development;Diagnosis;Disease;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Estrogen Receptors;experience;Family;Flow Cytometry;Future;G-Protein-Coupled Receptors;Gene Expression;genetic signature;Genetic Transcription;Goals;Human;Immune;Immunobiology;Immunofluorescence Immunologic;immunoreactivity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved outcome;in silico;inhibitor;innovation;Laboratories;Link;Lymphoma;Lysophosphatidic Acid Receptors;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mentorship;Metastasis Induction;Modeling;Molecular;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;novel;Oncogenic;Organoids;Outcome;outcome prediction;overexpression;PAR-1 Receptor;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmacologic Substance;Phenotype;Phosphotransferases;Physicians;pre-clinical research;Production;Progesterone Receptors;Prognosis;programs;Protease Inhibitor;protein complex;Proteins;Proteomics;receptor;Receptor, Angiotensin, Type 1;recruit;Regulation;Research Training;Resistance development;response;Role;scaffold;Scientist;Series;Signal Transduction;Signaling Protein;single-cell RNA sequencing;skills;Solid Neoplasm;Spatial Distribution;Specimen;targeted treatment;Techniques;Therapeutic;Training;Transcriptional Activation;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;Woman;Women's mortality

PROJECT_TITLE: Immunosuppressive impact of the GPCR/MALT1 protease axis in triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (22)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Hyperphosphorylation of tau, a microtubule associated protein, is a hallmark of neurofibrillary tangles (NFT) that correlate with cognitive impairment in Alzheimer's disease (AD) patients. I propose to utilize unbiased single-cell transcriptomic profiling and electrophysiological measurements of brain slices to elucidate the cellular and molecular mechanisms underlying the neurotoxicity and cognitive effects of hyperphosphorylated tau. The proposed studies will provide greater insights into the pathogenic mechanisms of AD and tauopathies.

PI_NAMEs: PHAN, DUY  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Academic skills;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Area;Bioinformatics;Biological Models;biophysical properties;Brain;career;cell type;Church;Cognition;Cognitive;Cognitive deficits;comparison control;Cryoelectron Microscopy;Data;Defect;Detergents;Development;Dose;Electrophysiology (science);Exhibits;Exposure to;Future;glial activation;Heparin;Hippocampus;Human;hyperphosphorylated tau;Impaired cognition;In Situ Nick-End Labeling;In Vitro;in vivo;Injections;insight;Knowledge;Learning;Long-Term Potentiation;Measurement;Memory;Mentors;Microtubule-Associated Proteins;Molecular;mouse model;multidisciplinary;Mus;Nerve Degeneration;Nervous System;Neurites;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimmunology;neuroinflammation;neuron loss;Neurons;neurophysiology;Neurosciences;neurotoxic;neurotoxicity;Pathogenicity;Pathologic;Pathology;Patients;Phosphorylation Site;Physicians;Physiological;Proteins;Recombinants;Research;Research Personnel;sarkosyl;Scientist;single-cell RNA sequencing;Slice;Structure;Synaptic plasticity;System;tau aggregation;tau Proteins;tau-1;Tauopathies;Techniques;Testing;Therapeutic;Tissues;Toxic effect;Training;transcriptomic profiling;treatment strategy;Wild Type Mouse;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms of Neurotoxicity and Cognitive Deficits Due to Hyperphosphorylated Tau

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PI_NAMEs: MOHAMED, TAREK MAGDY (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: African American;African American population;Antioxidants;Biochemical;Biological Assay;Biology;Calcium;Cardiac;Cardiac Myocytes;cardioprotection;Cardiotoxicity;Cardiovascular Diseases;caucasian American;cohort;CRISPR/Cas technology;Data;Disease;Doxorubicin;EPHA2 gene;Genes;Heart;heart cell;Hepatic;high risk;Human;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inflammatory marker;Knockout Mice;Mitochondria;Mus;novel;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Production;Race;racial disparity;Regulation;Role;Severities;Signal Transduction;transcriptome sequencing

PROJECT_TITLE: Role of oxidative stress in doxorubicin-induced cardiotoxicity racial disparities


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Sarcopenia

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative RNA is cut into pieces that are either included or excluded from a final product that is made into protein, and can lead to changes in protein function and abundance. Transposable elements are parts of the genome that have copy-pasted themselves to constitute >50% of our DNA, with their expression implicated in inflammation. We will study these two mechanisms in the aging muscle to uncover insights that may help prevent muscle function decline with age with the ultimate goal of improving our health as we age.

PI_NAMEs: MUSTELIN, TOMAS M (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Address;Affect;Age;age acceleration;age effect;age related;age related decline;Aging;aging mechanism;aging process;aging related;aging related disease;Alternative Splicing;Amino Acid Sequence;analysis pipeline;Biology;Biopsy;Cell Aging;cohort;computational pipelines;Data;Data Set;Detection;Disease;DNA;DNA Sequence Alteration;DNA Transposable Elements;Elderly;Endogenous Retroviruses;Enzymes;Equilibrium;Event;Exclusion;Exons;Family;Fostering;frailty;Gene Expression;Generations;Genes;Genetic Transcription;Genome;Genomics;Genotype-Tissue Expression Project;Glucose;Goals;Health;healthy aging;high reward;high risk;Histone Deacetylase;Immune system;improved;Individual;Inflammaging;Inflammation;Inflammatory;inflammatory marker;insight;Interferon Type I;Interferons;Lamin Type A;Long Interspersed Elements;member;Messenger RNA;Metabolism;Molecular;mRNA Precursor;Muscle;muscle aging;muscle form;Muscle function;Mutation;neoantigens;normal aging;novel;Nuclear Envelope;Older Population;overexpression;Participant;Performance;prevent;Production;Progeria;protein aminoacid sequence;protein function;Protein Isoforms;protein structure;Proteins;Proteome;Publishing;Regulation;Reporting;Research;Retrotransposon;Risk;RNA;RNA Degradation;RNA Splicing;RNA, Messenger, Splicing;Role;sarcopenia;secondary analysis;senescence associated secretory phenotype;Short Interspersed Nucleotide Elements;Sirtuins;Skeletal Muscle;Solid;Somatic Mutation;Source;Terminator Codon;Testing;TP53 gene;Transcript;transcriptome;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Alternative splicing and expression of transposable elements in aging skeletal muscle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-S (02)]


NIH_SPENDING_CATS: Infectious Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Group B Streptococcus (GBS), a frequent colonizer of the vaginal tract, is also a leading cause of neonatal sepsis and meningitis and can be transmitted to a newborn during vaginal delivery or by ascension into the uterus during pregnancy. We have found that GBS is associated with the Gram-negative mucin-degrading obligate anaerobe Akkermansia muciniphila, a novel vaginal commensal, and in pregnant females the presence of both GBS and A. muciniphila coincide with pre-term birth. This proposal aims to characterize the properties of A. muciniphila that contribute to GBS persistence and how mucin-degradation alters the vaginal environment to promote GBS ascension.

PI_NAMEs: MARROQUIN, STEPHANIE MICHELLE (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adherence;adverse pregnancy outcome;Air;Anaerobic Bacteria;antagonist;Bacteria;Bacterial Adhesins;Biological Assay;Cell Communication;Cell Culture Techniques;Cell Physiology;Cells;Cervical;co-infection;Coculture Techniques;commensal microbes;CXCL1 gene;CXCL2 gene;Data;differential expression;Disease;Endocervical Mucosa;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Female;female reproductive tract;Fetus;Fimbriae Proteins;Flow Cytometry;Fluorescence Microscopy;Gene Expression;Genes;Genetic Transcription;Group B Streptococcus colonization;Human;IL8 gene;Immune;Immune response;immunoregulation;in utero;in vivo;Infection;Innate Immune Response;Interleukin-10;Interleukin-6;intraamniotic infection;Island;Liquid substance;Mediating;Meningitis;Methods;microbial;microbiome research;microbiota;Modeling;mouse model;MUC5B gene;Mucins;Mus;mutant;Neonatal;Neonatal meningitis;neonatal sepsis;Neurologic;neutrophil;Neutrophil Infiltration;Newborn Infant;novel;Organism;pathobiont;Pathway interactions;Pilum;Pregnancy;pregnant;Premature Birth;Premature Rupture Fetal Membranes;Production;Property;Protein Subunits;Proteins;recruit;Risk;Role;Sepsis;Signal Transduction;stillbirth;Streptococcus Group B;Structure;Surface;synergism;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Uterus;Vagina;Vaginal delivery procedure;vaginal microbiota;vaginal mucosa;Woman

PROJECT_TITLE: Elucidating the role of Akkermansia muciniphila in Group B Streptococcal vaginal colonization and ascending infection


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_CITY: MIAMI

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE. World Trade Center (WTC) general responders (GR) carry a significant public mental health (MH) burden related to their work in the WTC collapse. Many have increasingly moved to Florida, representing a substantial and ethnically diverse number of GRs who are away from their NY-based WTC support system, creating a need for personalized, accessible MH care. Responsive to the need to (a) develop efficacious MH treatments for the WTC responders (Zadroga Act, Title 42 USC §300mm–51) and (b) advance health equity, this research application from MPIs from a Hispanic-Serving Institution, proposes to assess the feasibility, acceptability, and efficacy of Clinician-Supported (CS) PTSD Coach, originally developed for English speaking military veterans but never tested with WTC responders, for reducing symptoms of PTSD, depression, anxiety, and sleep disturbance among English and Spanish speaking WTC GRs. If successful with the Florida cohort, CS PTSD Coach will be a readily deployable intervention to reduce PTSD, depression, and related symptoms among the dispersed English and Spanish-speaking WTC GRs.

PI_NAMEs: LUCCHINI, ROBERTO G;MACGOWAN, MARK J (contact)

PROJECT_TITLE: Clinician-Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center Responders in Florida.


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Genetics;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE Pathogenic germline mutations in the CDH1 gene significantly elevate the risk of hereditary diffuse gastric cancer, prompting many carriers to undergo prophylactic total gastrectomy at a young age due to the disease’s poor survival rates. However, the lack of fundamental understanding of the molecular and cellular mechanisms underlying premalignant disease initiation and evolution poses a barrier to precision approaches for early interception. To address this gap, we propose to construct a multimodal, spatial, and 3-dimensional (3D) atlas utilizing advanced techniques in 3D reconstruction, visualization, and artificial intelligence-driven predictive modeling.

PI_NAMEs: HWANG, TAE HYUN ;LI, MINGYAO ;MANSFIELD, PAUL F;WANG, LINGHUA  (contact)

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: 3-Dimensional;Address;Advanced Development;Age;Artificial Intelligence;Atlases;cancer initiation;Cancer Patient;cancer risk;cancer type;Carcinoma;CDH1 gene;cell type;Cells;cellular imaging;Chronic;cohort;Complex;computer framework;Computer Models;Coupled;deep learning algorithm;Development;Diffuse;Diffuse gastric cancer;Dimensions;disability;Discipline;Disease;Disease Progression;Early Diagnosis;Epithelial Cells;Event;Evolution;exome sequencing;Family Cancer History;Gastrectomy;Gastric mucosa;Germ Lines;Germ-Line Mutation;Grant;hereditary risk;high risk;Histologic;Human;Imaging Techniques;In Situ;Incidence;Individual;Indolent;Inherited;innovation;insight;Intercept;Lesion;longitudinal analysis;Longitudinal Studies;Machine Learning;Malignant Neoplasms;malignant stomach neoplasm;Maps;Methods;Modeling;Molecular;molecular imaging;Molecular Profiling;Mucous Membrane;multimodality;Mutation;mutation carrier;Narration;Nature;Neighborhoods;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;operation;Pathogenesis;Pathogenicity;Pathologic;Patients;personalized approach;Phase;Phenotype;Positioning Attribute;predictive marker;predictive modeling;premalignant;Prevention strategy;Preventive measure;Probability;Prognosis;Prognostic Marker;prophylactic;Prospective cohort;Proteomics;psychosocial;Race;racial diversity;reconstruction;Research;Resolution;Resources;Retrospective cohort;Risk;Risk Reduction;risk stratification;Sampling;Scientist;spatiotemporal;Stomach;Stromal Cells;Survival Rate;Techniques;Technology;Three-dimensional analysis;timeline;Tissues;tool;transcriptomics;tumor;tumor initiation;tumor microenvironment;tumor progression;Variant;Visualization;Work;young adult

PROJECT_TITLE: Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M3)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative South Africa (SA) is home to the largest number of people with HIV (PWH) in the world. Community Health Worker (CHW) programs have been rolled out to improve HIV care engagement in SA, yet mental health (MH) conditions, particularly depression and harmful alcohol use, are prevalent non-communicable diseases that remain significant barriers to care engagement, which CHWs often lack training for addressing. This study will develop home-based CHW training program to improve HIV care engagement among patients with common MH challenges and understand how to shift clinic-based interventions to home-based delivery.

PI_NAMEs: CARNEY, TARA ;MAGIDSON, JESSICA F (contact);MYERS, BRONWYN

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Africa South of the Sahara;Alcohol consumption;antiretroviral therapy;Area;barrier to care;Behavioral;care outcomes;care systems;Caring;Clinic;clinical care;Clinical Research;Collaborations;community based care;Community Health;Community Health Aides;community setting;community-centered;comparison intervention;Consolidated Framework for Implementation Research;design;Disease;Disease Progression;Distress;Educational workshop;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation trial;Evidence based intervention;Feedback;Health;Health Services Accessibility;health training;HIV;Home;Home visitation;human centered design;implementation barriers;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Individual;Infrastructure;innovation;interest;Intervention;intervention delivery;Interview;Lead;Leadership;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;Outcome;Pathway interactions;patient population;Patients;Persons;Policy Maker;preference;primary care services;Problem Solving;problem solving therapy;programs;Provider;psychologic;Psychosocial Influences;Public Health;Quality of life;Research;screening;Services;South Africa;Structure;student training;Symptoms;Techniques;Testing;therapy adherence;Training;Training Programs;transmission process;treatment as usual;Viral;Work;worker safety

PROJECT_TITLE: Home-Based Community Health Worker Support for Mental Health among People Living with HIV in South Africa: A Hybrid Effectiveness Implementation Trial

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Data Science;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Pediatric;Precision Medicine;Rare Diseases

PHR: Project Narrative Patients with craniosynostosis often require surgical correction but their treatment outcomes are highly variable and there are no methods to quantitatively characterize continuous process of head shape normalization after corrective surgery. Therefore, the choice of the most appropriate surgical procedure for each patient is highly dependent on expert qualitative evaluation and the experience of the clinical team. This proposal aims to quantify how patient-specific factors such as age, sex, and pre-surgical severity of anomalies affect head shape normalization after surgical treatment using a large retrospective dataset, to quantitatively compare outcomes between different surgical approaches, and to determine the optimal surgical approach personalized to each patient.

PI_NAMEs: ELKHILL, CONNOR  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aftercare;Age;age effect;Anatomic Models;Anatomy;Artificial Intelligence;Biological Sciences;Biology;Biometry;Cephalic;Childhood;Clinic;Clinical;Clinical Research;clinical translation;Colorado;convolutional neural network;cost;craniofacial;Craniofacial Abnormalities;Craniosynostosis;cranium;Data;Data Reporting;Data Set;Databases;deep learning;deep learning model;design;Development;Environment;Esthetics;Evaluation;experience;Future;Graph;Growth;Head;Image;improved;Informatics;Intervention;Intracranial Hypertension;Joint structure of suture of skull;Joints;Live Birth;Machine Learning;machine learning method;malformation;Manuals;Medical;Medical Imaging;Mentors;Methods;Modality;model building;Modeling;multidisciplinary;novel;Operative Surgical Procedures;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;Pediatric Hospitals;personalized approach;personalized medicine;Phenotype;Photogrammetry;Positioning Attribute;premature;Process;progression risk;Publishing;Qualitative Evaluations;Radiation;Research Personnel;Research Training;Resources;Risk;Risk Estimate;Severities;sex;Shapes;skills;statistical and machine learning;Statistical Methods;Statistical Models;surgery outcome;Surgical sutures;suture fusion;Techniques;Time;Training;Translational Research;treatment optimization;Treatment outcome;Universities;Validation;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Development of deep learning methods to optimize patient personalized treatment for craniosynostosis

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Neurodegenerative Diseases: Biology & Therapeutics December 4 - December 7, 2024 Neurodegenerative diseases exert a staggering cost to governments and societies, and thus have become an urgent concern to public health worldwide. The cost of Alzheimer’s disease in the U.S. alone in 2023 has exceeded a quarter trillion dollars. Unfortunately, detailed understanding of the disease processes critical for effective therapeutic interventions for many such disorders remains sketchy. Thus, basic research of the disease process is needed to develop novel diagnostic strategies and new therapeutics that might halt or stem disease progression. The Cold Spring Harbor Laboratory conference on Neurodegenerative Diseases: Biology & Therapeutics will advance knowledge in the field by bringing together top scientists with expertise in disparate aspects of neurodegeneration in an excellent venue that will provide an ideal forum for catalyzing scientific interactions and collaborations to accelerate discoveries of effective therapeutics for the treatments of neurodegenerative diseases.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Academia;Acceleration;Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Awareness;Basic Science;Biological Markers;Biology;biopharmaceutical industry;Businesses;Cellular biology;Clinical;Collaborations;Communities;Complex;cost;Data;data exchange;Development;diagnostic strategy;Disease;Disease Pathway;Disease Progression;Disparate;drug discovery;Ensure;Environment;Faculty;Feedback;forging;Fostering;Future;General Population;Goals;Government;graduate student;Human;Immune system;Individual;Industrialization;Industry;Information Dissemination;innovation;Institution;International;Knowledge;Laboratories;Learning;lectures;lipid metabolism;Measures;Medical;meetings;Methodology;Methods;Molecular;multidisciplinary;Nationalities;Nerve Degeneration;Neurodegenerative Disorders;novel;novel diagnostics;novel therapeutics;Parkinson Disease;Participant;Pathway interactions;Postdoctoral Fellow;posters;Process;protein folding;Public Health;Questionnaires;Reagent;reduce symptoms;Research;Research Institute;Research Personnel;Rights;Science;Scientist;senior faculty;skills;social media;Societies;stem;success;symposium;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy design;tool;Translational Research;unpublished works;virtual

PROJECT_TITLE: CSHL 2024 Conference on Neurodegenerative Diseases: Biology & Therapeutics

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Vision loss impacts millions of people globally and can lead to significant socioeconomic burden and reduced quality of life. Retinal imaging, especially functional imaging, is vital for the diagnosis and management of vision loss, however, existing methods poorly account for the astounding variety and diversity of retinal structural characteristics, such as differences within foveal specializations and differences within photoreceptors themselves. This project seeks to address some of these limitations by assessing how variations in retinal structure impact measures of visual function such as visual acuity and optoretinography.

PI_NAMEs: GAFFNEY, MINA M (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: adaptive optics;Address;Albinism;Anatomy;Assessment tool;Biological Assay;Biological Factors;Biology;Biomedical Engineering;Blindness;career;career development;cell replacement therapy;Cells;Characteristics;Circadian Rhythms;Clinical;Collaborations;Communication;computer program;Cone;Data;density;Diagnosis;diagnostic tool;Discipline;Disease Management;Economic Burden;efficacy testing;Engineering;experience;Eye;Fellowship;fovea centralis;Functional disorder;Functional Imaging;Future;gene therapy;Goals;graduate student;Health;Human;Image;Imaging Device;improved;in vivo;Individual;insight;Light;Measurement;Measures;Medical Students;Methods;Morphology;mosaic;Ophthalmoscopy;Opsin;Optics;Pathologic;Pathology;Persons;Photoreceptors;Physiological;Population;Privatization;Procedures;Psychophysics;Publishing;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Research Subjects;Research Training;Resolution;response;Retina;Retinal Cone;retinal imaging;retinal neuron;retinal rods;Sampling;Scanning;Scientific Advances and Accomplishments;Signal Transduction;skill acquisition;skills;socioeconomics;software development;Stimulus;Structure;Systemic disease;Testing;Time;tool;training opportunity;Variant;Vision;Vision research;Visual Acuity;Visualization;Work

PROJECT_TITLE: Characterizing retinal function using AOSLO based psychophysics and optoretinography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]