NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: 3-Dimensional;alertness;Animal Behavior;Area;area striata;Astronomy;Behavior;Behavioral;Behavioral Model;Biological;Brain;Brain region;Calibration;Cell Nucleus;cell type;Cells;Communities;Complex;Data;data modeling;Data Set;design;Development;Diameter;Dimensions;Doctor of Philosophy;Education and Outreach;Ensure;Event;experimental study;Fire - disasters;Gene Expression;Individual;interest;laboratory experiment;Lead;Learning;Link;Measures;Methods;Mission;Modeling;Molecular;molecular phenotype;Motivation;Mus;network models;neural;Neuromodulator;Neurons;new technology;Noise;nonhuman primate;optogenetics;Output;Pattern;Perception;Play;Population Dynamics;Positioning Attribute;Preparation;Primates;Probability;Property;Pupil;Reaction Time;Research Project Grants;Resolution;Rodent;Role;Satiation;Sensory;sensory cortex;sensory input;Signal Transduction;Source;Specific qualifier value;Speed;Stimulus;Structure;Technology;Testing;Text;theories;Thirst;Time;tool;Training;Typology;vigilance;Visual Perception;visual stimulus;Work;Writing

PROJECT_TITLE: Research Project 1 - Developing and applying tools to probe internal state dynamics of perception and motivation


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Studies show large disparities in alcohol-involved sexual assault in bisexual women (BW) compared to heterosexual women. Research into the underlying factors that can explain these inequalities constitutes a critical area for public health. The proposed research will use multiple methods and datasets to identify modifiable determinants of alcohol-involved sexual assault within BW across the lifespan that can be used to inform public health interventions that reduce alcohol-involved sexual assaults in this vulnerable population.

PI_NAMEs: FORD, JESSIE V (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adolescence;Adult;adverse outcome;Affect;Age;Alcohol consumption;alcohol involvement;alcohol risk;Alcohols;Area;Attention;Bisexual;career;career development;Chicago;college;Cross-Sectional Studies;Data;Data Collection;Data Set;data structure;design;Development;Development Plans;Discrimination;Disparity;drinking;Educational workshop;epidemiological model;Etiology;experience;Exposure to;General Population;geographic difference;Goals;Greek;hazardous drinking;Health;health data;health disparity;Heterosexuals;Individual;Inequality;innovation;Institute of Medicine (U.S.);Institution;Interview;Lesbian Gay Bisexual;LGBT Health;Life;Life Experience;life span;Literature;Longitudinal cohort;Measurement;Measures;men;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;middle age;minority stress;Modeling;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;outcome prediction;Pathway interactions;Positioning Attribute;prevent;Production;prospective;protective factors;Public Health;public health intervention;recruit;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Risk Taking;Sampling;sexual assault;Sexual Health;sexual identity;sexual minority;Site;skill acquisition;skills;social;Statistical Methods;structural determinants;Surveys;symposium;Testing;Time;Training;training data;Universities;Variant;Vulnerable Populations;Woman;Women's study;Work;young adult

PROJECT_TITLE: Alcohol-Involved Sexual Assault among Bisexual Women: Disentangling Mechanisms of Risk at Individual, Interpersonal, and Structural Levels Across the Lifespan

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Parkinson’s disease (PD) is a common disorder among the elderly. PD is progressive and therefore with time increases costs of healthcare and financial and emotional burden to the caretakers. As the world's population ages, PD is a growing concern. Current therapies alleviate the symptoms, but do not stop the progress of the disease. Our macrophage-mediated GDNF delivery may realize the neuroprotective and neurorestorative effects of this molecule, leading to a long-sought treatment for PD patients.

PI_NAMEs: LI, SENLIN  (contact)

PROJECT_TERMS: Acute;Adverse effects;Affect;Age;AMD3100;Apoptosis;Applications Grants;Area;Aspirin;behavior test;Brain;brain parenchyma;brain tissue;Cell Physiology;Cell Survival;Cells;Chimerism;Chronic;Clinical Research;clinical translation;Clinical Trials;Corpus striatum structure;CSF3 gene;CXCR4 gene;Data;Development;Dinoprostone;Disease;Dopamine;dopaminergic neuron;Dose;Effectiveness;efficacy validation;Elderly;Emotional;Ensure;Evaluation;Evolution;Foundations;Functional disorder;Funding;Future;Gene Delivery;Gene Modified;gene therapy;Genetic;Genetic Engineering;glial cell-line derived neurotrophic factor;Health Care Costs;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Home;Homing;Human;improved;in vivo;Infiltration;Inhibition of Apoptosis;innovation;insight;interest;Intervention;irradiation;lentivirally transduced;Macrophage;Measures;Mechanics;Mediating;Methods;Microglia;migration;mitopark mouse;Modeling;Molecular;monocyte;mortality;Motor;motor impairment;mouse model;MPTP mouse;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Injury;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;neurorestoration;Neurotoxins;neurotrophic factor;nigrostriatal degeneration;novel;novel strategies;old mice;Operative Surgical Procedures;Parkinson Disease;Parkinsonian Disorders;parkinsonian rodent;Pathway interactions;Patients;Penetration;Peripheral;Population;pre-clinical;preconditioning;Process;promoter;Property;Prostaglandins;protective effect;Protocols documentation;Receptor Signaling;reduce symptoms;Reporting;Reproducibility;response;Signal Transduction;single-cell RNA sequencing;Site;stem cell gene therapy;Stromal Cell-Derived Factor 1;Substantia nigra structure;success;Symptoms;System;Technology;Testing;Therapeutic;Time;transcriptome;transgene expression;translational potential;Transplantation;Treatment Efficacy;Validation;Veterans;Work

PROJECT_TITLE: Macrophage-Mediated Gene Delivery of Neurotrophic Factors in Parkinson's Disease


FUNDING_MECHANISM: OTHERS

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Depression is the leading cause of disability worldwide and prevalent in veterans, and current treatments rely on an inefficient trial and error approach for prescribing treatment that is not based on objective biological tests. Better understanding of how changes in the brain are related to symptoms of depression is necessary to develop more targeted treatments. The role of the corticostriatal circuit in approach and avoidance behavior is well characterized in human and animal models, and implicated in symptoms of depression. This proposal tests whether a marker of approach behavior, value-based attentional capture, is a sensitive readout of corticostriatal dysfunction in depression. Brain imaging, brain stimulation, and computational modeling will be used to characterize neurobiobehavioral substrates of depression, with the long term goal of furthering development of novel brain stimulation interventions targeting specific brain circuitry and depressive symptoms.

PI_NAMEs: MILLS-FINNERTY, COLLEEN  (contact)

PROJECT_TERMS: addiction;Address;Anhedonia;Animal Model;Applications Grants;approach behavior;Area;Attention;attentional bias;avoidance behavior;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Biological;Biological Testing;Brain;brain abnormalities;brain circuitry;Brain imaging;Brain region;Clinical Research;Clinical Trials;cognitive process;Computer Models;Corpus striatum structure;cost;Data;depressive symptoms;Development;direct application;disability;Disease;distraction;Doctor of Philosophy;Educational workshop;Environment;Eye;Failure;FDA approved;Feedback;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Grant;high reward;human model;improved;Individual Differences;information model;insight;Intervention;K-Series Research Career Programs;Learning;Link;Manuscripts;Measures;Medial;meetings;Mental Depression;Mentors;Modeling;motivated behavior;Motivation;neural circuit;Neurobiology;neuroimaging;Neurologic;novel;Obsessive-Compulsive Disorder;Parkinson Disease;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;Population;practical application;Prefrontal Cortex;Process;Protocols documentation;Reaction Time;remediation;Research;Research Project Grants;Resources;response;responsible research conduct;Rewards;Role;Severities;Signal Transduction;Site;skills;social;Stimulus;Stroke;symptomatic improvement;Symptoms;Testing;Therapeutic;Time;Training;Transcranial magnetic stimulation;United States;United States Department of Veterans Affairs;Universities;Veterans;Visual Fields;Visual Perception;Walking;Work;Writing

PROJECT_TITLE: Causal brain mechanisms of value-based attentional capture in depression


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: SEIDEMANN, EYAL J (contact)

PROJECT_TERMS: Adopted;Affect;Anatomy;Animals;Area;area striata;Attention;Behavior;Behavioral;Brain;Brain region;brain size;Collaborations;Complex;Computer Models;Coupling;Decision Making;Discrimination;discrimination task;Doctor of Philosophy;dynamic system;Electric Stimulation;Elements;Event;experimental study;Factor Analysis;frontal eye fields;genomic signature;Goals;Image;insight;Lead;Link;Macaca;Measurement;Measures;Mediating;Methods;Modeling;Monkeys;Motivation;Motor;Mus;neural;neural circuit;Neuromodulator;Neurons;Noise;novel;oculomotor;Optics;optogenetics;Pattern;Perception;Performance;Population;Primates;Property;Reading;recruit;Research Project Grants;response;Rodent;sample fixation;spatiotemporal;Stimulus;Testing;tool;Training;Uncertainty;Variant;Visual;visual discrimination;Work;Writing

PROJECT_TITLE: Research Project 2 - Internal state dynamics of primate perception and decision-making


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Sepsis strikes 750,000 Americans every year; most of these patients will survive the acute stage of sepsis only to end up back in the ICU, weeks later, with hospital-acquired infections. The objective of this competitive renewal is to study how changing the “starting point” of the immune system (i.e., mature, adult-like immune system of ‘dirty’ mice that have experienced physiological microbial exposure vs. naïve, neonate-like immune system of SPF mice) influences the magnitude of the acute innate immune response to a septic event. We will also be using a human microbiota-associated mouse model that allows transfer of human microbiota to a fully developed mouse to investigate how intestinal microbiota dysfunction during sepsis affects the magnitude of the innate immune response and promotes increased incidence of late-onset mortality.

PI_NAMEs: GRIFFITH, THOMAS S (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Affect;American;Antibiotic Resistance;Antibiotics;apoptosis in lymphocytes;Back;Biology;Birth;cecal ligation puncture;Cells;Cessation of life;Clinical;Clinical Research;clinically relevant;commensal microbes;Critical Care;Critical Illness;Cues;cytokine;cytokine release syndrome;Data;emerging pathogen;Enteral Nutrition;Environment;Event;experience;Experimental Models;experimental study;Exposure to;fitness;Functional disorder;germ free condition;gut microbiome;gut microbiota;House mice;Housing;Human;Human Biology;human microbiota;Hyperactivity;Immune;Immune response;Immune system;Immunity;Immunologics;Immunosuppression;improved;Incidence;Infection;Infiltration;Inflammatory;Innate Immune Response;Interferon Type II;Interleukin-1 beta;Interleukin-6;Interruption;Intra-abdominal;Knowledge;Laboratory mice;Lead;Life;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Medical;Microbe;microbial;microbiota;Modeling;monocyte;mortality;mouse model;Mus;neonatal human;neonate;neutrophil;Nosocomial Infections;novel;Organ;Organism;Outcome;pathogen;pathogen exposure;Pathogenesis;pathogenic microbe;Pathogenicity;Patient Care;Patients;Pattern;Pattern recognition receptor;Peritoneal;Phagocytes;Physiological;Play;polymicrobial sepsis;Population;pre-clinical;Public Health;Publishing;receptor expression;Reproducibility;Research;Research Personnel;resident commensals;Residual state;response;Role;routine care;secondary infection;Sepsis;septic;septic patients;Shapes;Signal Transduction;stem;T memory cell;Testing;TLR4 gene;TNF gene;tool;Training;Translating;Vaccination;virtual;Virulence Factors

PROJECT_TITLE: Using microbially-experienced mice to study the innate immune response in sepsis


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Missed diagnosis of child abuse, in which abusive injury goes unrecognized or is misattributed to accidental trauma, is among the gravest examples of pediatric diagnostic error. At the same time, there are striking disparities in child abuse evaluation. To lay the groundwork for improved accuracy and equity of abuse diagnosis in pediatric primary care, the objectives of this proposal are to 1) identify markers of abuse in primary care EHR data, 2) characterize clinician diagnostic-process failure modes using EHR-based simulation, and 3) develop and prioritize strategies for improving primary care diagnosis of abuse.

PI_NAMEs: RASOOLY, IRIT R (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Averting Diagnostic Error Through Improved Recognition of Child Abuse

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: GANGULI, SURYA  (contact)

PROJECT_TERMS: Algorithms;Astronomy;Attention;Behavior;Biological Models;Brain;Brain region;cell type;Cells;clinically relevant;Collaborations;computational neuroscience;computer framework;computerized tools;Computing Methodologies;control theory;curse of dimensionality;Data;design;Doctor of Philosophy;empowerment;excitatory neuron;Experimental Designs;Experimental Models;experimental study;Feedback;field theory;flexibility;Freedom;Generations;Hippocampus;inhibitory neuron;insight;Joints;Knowledge;Learning;Macaca;Maintenance;Measures;Methods;millisecond;Modeling;Monkeys;multisensory;Mus;network models;neural;neural circuit;neural network;Neurons;Neurosciences;next generation;Observational Study;oculomotor;Optics;optogenetics;Outcome;Pattern;Play;Positioning Attribute;Property;Reading;recruit;Research Project Grants;Research Project Summaries;Resolution;response;Role;Satiation;Sensory;sensory input;sensory integration;sensory system;Signal Transduction;spatiotemporal;statistics;Stimulus;Synapses;System;Technology;Testing;theories;Thirst;Time;tool;Uncertainty;Update;virtual reality;Visual;Work;Writing

PROJECT_TITLE: Research Project 3 - Theory and computation of internal state dynamics


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Multiple sclerosis (MS) is a cause of significant morbidity amongst veterans. Experimental autoimmune encephalomyelitis (EAE) is a well-established mouse model for MS. In prior studies, we have found a novel immune suppressive role for central nervous system myelin antigen-targeted CD8+ immune T cells (CNS- CD8), which can protect against EAE, halt EAE progression, and reverse ongoing EAE. In the proposed studies, we will dissect the mechanisms of such CNS-CD8-mediated disease suppression and investigate novel approaches for activating and enhancing this population with the goal of developing innovative treatment strategies for this disease and providing important insights into an overlooked area of MS immunology.

PI_NAMEs: KARANDIKAR, NITIN J (contact)

PROJECT_TERMS: Address;Adoptive Immunotherapy;Adoptive Transfer;Affect;American;Animal Model;Anti-Inflammatory Agents;Antigen Targeting;Antigenic Specificity;Antigens;Area;arm;Attenuated;Autoimmune;Autoimmune Diseases;Automobile Driving;autoreactive T cell;autoreactivity;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Central Nervous System;central nervous system demyelinating disorder;Characteristics;Chronic;CNS Demyelinating Autoimmune Diseases;cytotoxic;cytotoxicity;Data;Demyelinating Diseases;Demyelinations;Dendritic Cells;Development;Disease;Dissection;Exhibits;Experimental Autoimmune Encephalomyelitis;Experimental Models;experimental study;Goals;Granzyme;Histocompatibility Antigens Class I;Histology;IFNGR1 gene;Immune;Immunization;Immunologics;Immunology;immunopathology;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in vivo;Infection;Inflammatory;innovation;insight;Interferon Type II;Intervention;ITGAX gene;Listeria monocytogenes;Mediating;Modeling;Molecular;Morbidity - disease rate;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis treatment;Mus;Myelin;neuroinflammation;novel;novel strategies;Organ;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;perforin;Peripheral;Phenotype;Population;prevent;Process;Production;Publishing;receptor;Recurrent disease;Regulation;Regulatory T-Lymphocyte;Relapse;Reporting;Role;Signal Transduction;Site;SJL Mouse;T cell response;T-Lymphocyte;Therapeutic;Time;trafficking;treatment strategy;vaccination strategy;Veterans;Work

PROJECT_TITLE: Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Orphan Drug;Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT RELEVANCE: We propose to optimize and validate an AI-enabled Digital Pathology Platform (ADAPT) for multi-cancer diagnosis, prognosis and prediction of therapeutic benefit. By integrating the AI- pathomic tools within PathPresenter, a widely used digital pathology image analysis platform, ADAPT will have a global footprint for the prognostic and predictive tools. ADAPT will be validated in the context of estrogen receptor positive (ER+) and triple negative (TN) breast cancer, oral cavity squamous cell carcinoma (OC-SCC), and prostate cancer for (1) prognosticating recurrence, (2) predicting pathologic complete response to neoadjuvant chemotherapy, (3) predicting benefit of adjuvant chemotherapy and radiotherapy as well as for (4) identifying individuals in whom radiation therapy can be de-intensified, respectively.

PI_NAMEs: MADABHUSHI, ANANT  (contact);SHET, TANUJA

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Accounting;Acute;Adjuvant Chemotherapy;Adjuvant Radiotherapy;Adjuvant Therapy;Affect;Asian Americans;behavioral outcome;Biological Assay;Breast;Breast Cancer Patient;Cancer Center;cancer diagnosis;Cancer Patient;caucasian American;Cell Nucleus;Chemotherapy and/or radiation;Clinical;Clinical Trials;Collaborations;companion diagnostics;Computer Vision Systems;cost comparison;Data Set;Diagnosis;Diagnostic tests;digital;digital imaging;digital pathology;Early identification;Estrogen receptor positive;Gene Expression;Gene Expression Profiling;Genomics;Head and Neck Cancer;Health Services Accessibility;Hematoxylin and Eosin Staining Method;high risk;high risk population;Image;Image Analysis;improved;In complete remission;India;Individual;innovation;low and middle-income countries;Malignant Breast Neoplasm;malignant mouth neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;men;Molecular;morphological criteria;Morphology;mouth squamous cell carcinoma;Neoadjuvant Therapy;Nomograms;oncotype;Oral cavity;Outcome;outcome prediction;overtreatment;Pathologic;Patient-Focused Outcomes;Patients;Pattern;Pattern Recognition;Pelvis;Performance;Population;Postoperative Period;precision medicine;predictive modeling;predictive test;predictive tools;Prevalence;Price;Prognosis;prognostic;prognostic assays;prognostic model;prognostic tool;prognostication;prospective;Prostate;prostate cancer risk;Radiation;Radiation therapy;Radiation Therapy Oncology Group;Recurrence;Recurrent disease;Resources;response;Risk;Role;Shapes;side effect;Slide;South Asian;Southwest Oncology Group;Stains;success;Testing;Therapeutic;Tissue Stains;Tissues;tool;treatment response;trial comparing;triple-negative invasive breast carcinoma;tumor behavior;Universities;Validation;Visual;Woman

PROJECT_TITLE: An AI-enabled Digital Pathology Platform for Multi-Cancer Diagnosis, Prognosis and Prediction of Therapeutic Benefit


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: GIOCOMO, LISA  (contact)

PROJECT_TERMS: alertness;Algorithms;area striata;Arousal;Automobile Driving;Bayesian Analysis;Behavior;Behavioral;Behavioral Paradigm;Brain;Brain region;Cells;Code;Collaborations;Complex;computer framework;Coupled;Cues;Data;Data Science Core;Decision Making;density;Detection;Development;discrimination task;Disparate;Doctor of Philosophy;driving behavior;Electrophysiology (science);entorhinal cortex;Environment;Etiology;flexibility;Hippocampus;Image;imaging modality;Individual;Lead;Maps;Measurement;Measures;Medial;Memory;Motivation;Movement;Mus;Nature;Navigation System;network models;neural;neural circuit;neuronal patterning;Neurons;novel;optic flow;Optics;optogenetics;Perception;Population;Positioning Attribute;predictive modeling;Primates;recruit;Research Project Grants;Resolution;Rodent;Satiation;Sensory;sensory input;Silicon;spatiotemporal;Techniques;technology development;Testing;theories;Time;two-photon;Uncertainty;virtual;virtual reality;virtual reality environment;Visual;Visualization;way finding;Weight;Work

PROJECT_TITLE: Research Project 4 - Internal state dynamics of navigation and memory


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Pain Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  The proposed study uses mixed methods, including claims-based analyses and qualitative interviews with key stakeholders, to examine insurance coverage for acupuncture. The training platform supports a long-term goal of designing insurer-driven interventional studies that help patients access evidence-based pain care.

PI_NAMEs: CANDON, MOLLY  (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acupuncture Therapy;adverse outcome;Affect;alternative treatment;American;Back Pain;behavioral health;care providers;career development;Caring;Characteristics;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinic;cohort;Coinsurance;Complex;copayment;cost;Cost Analysis;cost effective;cost effectiveness;Cost Sharing;Data;Deductibles;design;Disabling;Drops;evidence base;Evidence based treatment;follow-up;Follow-Up Studies;Goals;Grant;health care service utilization;health economics;health plan;Health Services Accessibility;Health Services Research;implementation strategy;Improve Access;Insurance;Insurance Carriers;insurance claims;Insurance Coverage;insurance plan;Integrative Medicine;Intervention Studies;Interview;Knowledge;knowledge base;Learning;Low Back Pain;Managed Care Programs;Measures;Medicaid;Medicare;medication compliance;Mentored Research Scientist Development Award;Mentorship;Methods;multimodality;non-opioid analgesic;Office Visits;Opioid;Opium;Outcome;Pain;Pain management;pain outcome;Patient Care;patient population;Patients;Physical therapy;Play;Policies;prescription opioid;Privatization;Proliferating;Provider;Publishing;Qualitative Methods;Qualitative Research;randomized trial;Reporting;Research;Research Activity;Research Design;Research Personnel;Risk;Role;Running;Sampling;Sampling Studies;skills;Structure;substance use;suicidal;Testing;Training;Training Activity;Translating;trend;visit adherence;Work

PROJECT_TITLE: Insurance Coverage for Acupuncture


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Rare Diseases;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Progressive resistance exercise has been shown as an effective therapy for many neurological disorders but has never been studied in patients with dystonia. The current study will employ functional MRI and TMS techniques to understand whether there are significant brain adaptation effects specific to dystonia pathophysiology in response to progressive resistance exercise in dystonia. The outcome of these studies will advance our understanding of pathophysiological underpinnings, which is critical for the initiation of a large scale clinical trial in patients with dystonia.

PI_NAMEs: WAGLE SHUKLA, APARNA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Activities of Daily Living;Advisory Committees;Alzheimer's Disease;Base Pairing;Behavioral;Blinded;botulinum neurotoxin injection;Brain;brain circuitry;Brain region;Cervical;Cervical Dystonia;Clinical;Clinical Research;Clinical Trials;Cognition;Control Groups;Data;Deep Brain Stimulation;Dose;Dystonia;effective therapy;Exercise;exercise program;exercise regimen;Exercise Therapy;Fatigue;Focal Dystonias;functional disability;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;Gait;Goals;grasp;improved;Intervention;Involuntary Movements;Measures;Mediating;Medical;Monitor;Moods;Motor;motor control;Motor Evoked Potentials;motor symptom;Movement;Movement Disorders;Muscle;Muscle Contraction;Muscle relaxation phase;muscle strength;Nervous System Disorder;network dysfunction;non-motor symptom;novel;Operative Surgical Procedures;Oral;Outcome;Outcome Study;Oxygen;Pain;Parkinson Disease;Participant;participant enrollment;Patients;Pharmaceutical Preparations;pharmacologic;Physical Function;physical therapist;Physiological;Pilot Projects;Posture;programs;Protocols documentation;Quality of life;Randomized;Range of motion exercise;Relaxation;resistance exercise;response;Rest;Role;Shoulder;Signal Transduction;Sleep;Smooth Muscle;standard of care;Stretching;symptomatic improvement;Symptoms;Techniques;Testing;Therapeutic;Training;Training Programs;Transcranial magnetic stimulation;Treatment outcome;trend

PROJECT_TITLE: Progressive resistance exercise and dystonia pathophysiology.

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The T35 Northwestern Summer Research Program for Medical Students provides an academically rich and fertile environment at the Feinberg School of Medicine, Northwestern University (NU), for 8 academically promising students interested in basic, translational and outcomes research in the NIDDK areas of interest from five participating medical schools in the Chicago metropolitan area (NU, Loyola, University of Chicago, University of Illinois, Rosalind Franklin). It provides a highly didactic 8-weeks of hands-on experience in the lab with mentorship from predominantly NIDDK-funded researchers that includes daily T35 Lunch Lectures, weekly T35 Trainee Meetings with the PD, a T35 Retreat with a NIDDK funded Visiting Professor and a Poster Session at the end of the summer. The program emphasizes the recruitment of students from underrepresented minorities and women, encourages the continuation of research after the T35 summer and will mentor students in a structured format until graduation and beyond, paving a path for medical students, especially URM and women, to become the next generation of clinician-scientists.

PI_NAMEs: LADNER, DANIELA P (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: academic standard;Area;Basic Science;career;Chicago;Event;experience;Faculty;Feedback;Female;Fertilization;Funding;Illinois;improved;Institutional Review Boards;interest;Knowledge;lectures;Literature;medical schools;Medical Students;meetings;Mentors;Mentorship;National Institute of Diabetes and Digestive and Kidney Diseases;Outcomes Research;posters;Process;professor;programs;Progress Reports;recruit;Research;Research Project Grants;Schools;Science;Scientist;skills;Students;summer program;summer research;Training Activity;Visit;Woman

PROJECT_TITLE: The Northwestern Summer Research Program for Medical Students

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE The proposed project targets reduction in mortality and morbidity from skin cancer via advancement of improved informatics tools to improve artificial intelligence development and clinical education for skin detection. Multi-modal International Skin Imaging Collaboration (M-ISIC) archive will advance machine learning and computer vision informatics tools to support large-scale multimodal ingestion, organization, registration, and curation of skin images and metadata datasets to improve skin cancer detection. With its open-source tools for automatic data quality control, ingestion, organization and curation, the M-ISIC archive will support the education of medical professionals and the development and clinical testing of automated diagnostic systems and eventually supporting flexible clinical translation of AI algorithms.

PI_NAMEs: KOSE, KIVANC ;ROTEMBERG, VERONICA MIRIAM (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;algorithm development;Algorithms;analysis pipeline;archive data;Archives;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Automation;Boston;Cancer Detection;cancer type;Clinical;clinical application;Clinical Distribution;clinical translation;Clinical Trials;Collaborations;Complex;Computer software;Computer Vision Systems;Custom;Data;data curation;data ingestion;data integration;data management;data quality;Data Set;Data Sources;data wrangling;Dermatology;design;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic platform;digital technology;Disparate;Early Diagnosis;Education;Evaluation;Experimental Models;flexibility;Goals;Health protection;Human;Image;image archival system;image registration;improved;Informatics;informatics tool;Ingestion;International;Intervention;Label;large datasets;Link;Machine Learning;Manuals;Medical Education;Melanoma;Metadata;Methods;microscopic imaging;Modality;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;multidimensional data;multimodal data;Multimodal Imaging;multimodality;next generation;Online Systems;open source;open source tool;Operative Surgical Procedures;Organizational Efficiency;Participant;Pathology;Performance;Persons;Plug-in;prevent;primary care clinician;Process;quality assurance;Quality Control;Radiology Specialty;reflectance confocal microscopy;Research;research clinical testing;Resolution;response;Retrieval;Screening for Skin Cancer;Skin;Skin Cancer;Skin Malignancy;Sorting;success;Tattooing;Techniques;teledermatology;Testing;tool;Training and Education;United States;Visual;Visualization;Work

PROJECT_TITLE: M-ISIC: A Multimodal Open-Source International Skin Imaging Collaboration Informatics Platform for Automated Skin Cancer Detection


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Rare Diseases

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Chronic rhinosinusitis is a disease of the sinonasal airways that causes significant morbidity and economic burden but for which the etiology is unknown. In this proposal, I seek to define causative mechanisms for this disease through defining alterations in the structure and function of the nasal submucosal glands, as well as key regulators of glandular development and remodeling in both mice and humans. Outcomes from this study will enable the design of therapeutics for the treatment and cure of this chronic and debilitating disorder.

PI_NAMEs: MAY, ALISON  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Ablation;Acinus organ component;acute rhinosinusitis;Adult;Advisory Committees;Affect;Airway Disease;Animal Model;Architecture;Biology;Breathing;career development;cell behavior;cell type;Cells;Cellular Morphology;Chronic;chronic rhinosinusitis;Cues;curative treatments;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;deep sequencing;design;Development;Dimensions;Disease;disorder prevention;Drainage procedure;Duct (organ) structure;Economic Burden;Educational workshop;Ensure;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;Exhibits;experimental study;Facial Pain;fetal;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Gland;gland development;Goals;Health Expenditures;Heterogeneity;Histologic;Human;Imaging Techniques;Immune System Diseases;Immunohistochemistry;Impairment;In Situ Hybridization;insight;Integration Host Factors;Knowledge;Location;loss of function;Lung;Maps;Measures;member;Molecular;Morbidity - disease rate;Morphogenesis;Morphology;mouse model;Mucous body substance;Mucous Membrane;mucus hypersecretion;Mus;mutant;Mutation;new therapeutic target;Nose;novel;Operative Surgical Procedures;Organ;organ repair;Organogenesis;Organoids;Outcome;Outcome Study;particle;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Penetrance;Phase;Phenotype;Polyps;Population;Positioning Attribute;Preventive treatment;Process;Publishing;Quality of life;Regulator Genes;Research;respiratory;rhinosinusitis;Role;Signal Pathway;single-cell RNA sequencing;Sinus;socioeconomics;Structure;Submucosa;Swelling;Symptoms;System;Techniques;Testing;Therapeutic;Three-Dimensional Imaging;Time;Tissues;Training;transcriptome sequencing;transcriptomics;United States

PROJECT_TITLE: Defining the role of respiratory gland patterning in rhinosinusitis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurosciences;Pediatric;Precision Medicine;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Dynamic changes in the 3D epigenomic landscape during corticogenesis remain mostly unexplored. We aim to identify the differences in 3D regulatory chromatin loops in six cell types from the prefrontal cortex across three critical developmental stages: third trimester, neonatal/infancy, and adolescence ages and interrogate the relationship between neuropsychiatric diseases associated variants and their target genes via chromatin loops. Our plan will generate a precious resource and reveal new insight into 3D chromatin architecture in human brain development and diseases.

PI_NAMEs: KRIEGSTEIN, ARNOLD ;SHEN, YIN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Adolescence;Adolescent;Affect;Age;Architecture;Astrocytes;ATAC-seq;autism spectrum disorder;Biological;Biological Process;Biological Testing;Brain;Budgets;Cell Lineage;Cell Maturation;Cell Separation;cell type;Cells;Chromatin;Chromatin Loop;Collaborations;Collection;Communities;Data;data integration;Data Set;Development;Disease;Distal;Elements;epigenome;epigenomics;excitatory neuron;Fluorescence-Activated Cell Sorting;Funding;Future;Gene Expression;Gene Expression Regulation;General Population;Genes;Genetic;genetic resource;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genomic locus;Goals;Health;Human;Human Genome;in vivo;induced pluripotent stem cell;infancy;insight;Interneurons;Knowledge;Ligation;Link;Maps;Medical Genetics;member;Methods;Microglia;Modeling;Nature;Neonatal;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropsychiatric disorder;neuropsychiatry;Newborn Infant;Nucleic Acid Regulatory Sequences;oligodendrocyte lineage;Pathway interactions;Patients;personalized medicine;Phenotype;Population;Prefrontal Cortex;promoter;Radial;Regulatory Element;Research;Resources;Sampling;Second Pregnancy Trimester;Single Nucleotide Polymorphism in Regulatory Sequence;Specific qualifier value;stem cells;Testing;Third Pregnancy Trimester;three dimensional structure;Trans-Omics for Precision Medicine;Transcriptional Regulation;transcriptome;transcriptomics;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Charting the 3D epigenome in human brain development and diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative According to a recent UNAIDS report, alcohol use is an overlooked factor in the HIV epidemic that requires greater attention. My proposed research will estimate the long-term, population impact of harmful alcohol use on HIV transmission and mortality, and will assess the value for money of investing in alcohol use interventions to reduce HIV transmission in the UTT era in Uganda. As countries in Sub-Saharan Africa seek to end the HIV epidemic, my research could provide impactful information for policymakers on integrating alcohol and HIV strategies and resource allocation.

PI_NAMEs: WYNN, ADRIANE MICHELLE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Africa South of the Sahara;AIDS prevention;Alcohol consumption;alcohol measurement;alcohol risk;alcohol use disorder;Alcohols;antiretroviral therapy;Attention;Award;binge drinking;career;career development;CD4 Lymphocyte Count;Clinical;Collaborations;Cost Analysis;cost effectiveness;Country;Data;Decision Making;Diagnosis;Disease;Disease Progression;disease transmission;economic evaluation;Effectiveness of Interventions;Epidemic;Epidemiology;Ethics;Evidence based intervention;Face;Failure;Funding;Goals;Grant;Health;health economics;high risk sexual behavior;HIV;HIV risk;HIV/AIDS;implementation facilitation;improved;Incidence;Individual;infectious disease model;insight;Intervention;Investments;Maps;Measures;Methods;Modeling;mortality;National Institute on Alcohol Abuse and Alcoholism;Pathway interactions;Pattern;Persons;Policies;Policy Maker;Population;Population Study;Preparation;Prevalence;prevent;Prevention;Public Health;Publications;Qualifying;Recommendation;reduced alcohol use;Reporting;Research;Research Priority;Resource Allocation;Resource-limited setting;Resources;response;Risk;Role;Rural;scale up;Sex Behavior;skill acquisition;skills;sociodemographics;Strategic Planning;Testing;transmission process;Uganda;United States National Institutes of Health;Update;uptake;Viral;Viral Load result;Virus Replication;Work;World Health Organization;Writing

PROJECT_TITLE: Modeling reductions in harmful alcohol use on HIV transmission and mortality in the era of universal test and treat in Uganda

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE While there has been a significant increase in the uptake of antiretroviral therapy among women living with HIV (WLHIV) in many low- and-middle income countries (LMICs), the coverage of cervical cancer screening and, treatment among WLHIV remains low. In this study, we aim to leverage the available infrastructure for HIV care and treatment programs in Nigeria to integrate cervical cancer screening and treatment and conduct a cluster randomized, hybrid type III trial design to assess the comparative effectiveness of a Core set of implementation strategies versus a Core+ (enhanced) set of implementation strategies to implement cervical cancer screening, onsite treatment, referral and referral completion, treatment, and retention in care among WLHIV. The overarching goal is to improve the health and life expectancy of WLHIV with co-occurring cervical cancer.

PI_NAMEs: AARONS, GREGORY  (contact);EZEANOLUE, ECHEZONA EDOZIE

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adoption;Adult women;Africa;African;Aftercare;anti-cancer research;antiretroviral therapy;arm;California;Cancer Burden;cancer care;Cancer Control;Cancer Etiology;cancer risk;Caring;Cervical Cancer Screening;Cessation of life;Clinical effectiveness;Communities;comparative effectiveness;Country;Data;Diagnosis;effectiveness outcome;Emergency Situation;Epidemic;evidence base;Exploration, Preparation, Implementation, and Sustainment;Female;General Population;Goals;Health;Health care facility;Health Personnel;Healthcare;HIV;HIV Infections;Hybrids;implementation evaluation;implementation outcomes;Implementation readiness;implementation science;implementation strategy;Improve Access;improved;Individual;Infrastructure;Intervention;Life Expectancy;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;meetings;Methods;mortality;Nigeria;Outcome;Persons;Population;Prevalence;programs;Protocols documentation;Randomized;Recommendation;Reporting;Research;Resource-limited setting;Resources;scale up;screening;Screening for cancer;service delivery;Services;System;treatment center;treatment program;treatment site;trial design;Universities;uptake;Woman;women's treatment;World Health Organization

PROJECT_TITLE: ACCESS: Accelerating Cervical Cancer Elimination through the integration of Screen-and-treat Services


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: FORT COLLINS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Plasmids are engineered pieces of DNA that are used for biological research and for manufacturing biologic drugs and therapeutics. Despite the central importance of plasmids to biomedical research and development, the scientific community does not have a standardized, validated and secure infrastructure for associating the physical DNA molecules with the electronic records that describe them. We are proposing to develop a new digital certificate technology that will permanently label the DNA molecules themselves with an identifier that will connect them to standardized electronic documents describing their sequence, function, history, and other essential information allowing scientists to use them in a reproducible, safe, and secure manner.

PI_NAMEs: PECCOUD, JEAN M (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Affect;Algorithms;Architecture;Bar Codes;bioinformatics pipeline;Biological;Biological Process;biological research;Biological Sciences;Biological Testing;Biology;Biomedical Research;Biotechnology;Cell Therapy;Certification;Circulation;Clinical Research;Code;Communities;Complex;computer network;Computer Security;Computers;cryptography;Data;Database Management Systems;design;Development;digital;DNA;DNA Sequence;Documentation;Electronics;Elements;Engineering;Ensure;Event;expression vector;follow-up;Fostering;Funding;Gene Expression;gene therapy;Generations;Genetic;genetic element;Genetic Engineering;Genome engineering;improved;Individual;Industry;Infrastructure;innovation;Investments;Knowledge;Label;Link;manufacture;medical specialties;Methodology;Methods;Modification;Molecular;Mutate;Mutation;Names;new technology;online resource;Persons;Pharmaceutical Preparations;Plasmids;Play;Printing;Production;Property;Publications;Recombinants;Recording of previous events;Records;Reproducibility;Research;research and development;Resources;response;Role;Safety;Scheme;Scientist;Secure;Security;Self Correction;Semiconductors;Signal Transduction;Software Engineering;Standardization;System;Technology;Technology Assessment;technology validation;Testing;Therapeutic;therapeutic protein;tool;Tube;United States National Institutes of Health;vaccine development;Validation;Variant;Visualization software;web site;Writing

PROJECT_TITLE: Development of a technology to certify engineered DNA molecules

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: MIAMI

ORG_NAME: MIAMI VA HEALTH CARE SYSTEM

PHR: Infection with H. pylori affects almost 4.4 billion people world-wide. According to the World Health Organization, National Cancer Institute, and epidemiological data, individuals with chronic H. pylori infection carry a 6-fold higher risk of developing gastric cancer. Recent studies of U.S soldiers deployed to the Middle East and Far East have shown that the incidence of H. pylori infection was 7.3 percent per year compared to 2.5 percent of U.S. military recruits living at home, which represents a major increase in risk. We will investigate molecular factors that promote H. pylori-induced inflammation and oncogenic signaling, leading to the development of gastric cancer. Our results will have a strong impact on understanding the biology and could have a potential role in the preventive, early diagnosis, and possibly therapeutic interventions in gastric cancer.

PI_NAMEs: EL-RIFAI, WAEL  (contact)

PROJECT_TERMS: Address;Adult;Affect;Antioxidants;Binding;Bioinformatics;Biological Process;Biology;Cancer Biology;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer statistics;carcinogenicity;Carcinogens;Caring;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Cessation of life;chemotherapy;Chronic;Classification;clinically significant;Data;design;Development;Diagnosis;Diagnostic;Early Diagnosis;epidemiologic data;Epithelial Cells;Epithelium;Etiology;Event;experience;Far East;FGF19 gene;FGFR4 gene;Fibroblast Growth Factor;Future;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric Intraepithelial Neoplasia;gastric tumorigenesis;genotoxicity;global health;Goals;Helicobacter Infections;Helicobacter pylori;high risk;Histologic;Home;Human;human tissue;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;Individual;Infection;Inflammation;Inflammatory;Intestinal Metaplasia;Knockout Mice;Knowledge;Ligands;Link;Malignant Neoplasms;malignant stomach neoplasm;Mediating;member;Middle East;Military Personnel;Molecular;mouse model;National Cancer Institute;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Oncology;Organoids;overexpression;Oxidative Stress;Pathology;patient derived xenograft model;Patients;Persons;Play;Population;Pre-Clinical Model;Preventive;prognostic;Reactive Oxygen Species;recruit;Regulation;Reporting;Resistance;response;Risk;Risk Factors;Role;Signal Transduction;Soldier;STAT3 gene;Stimulus;Stomach;Survival Rate;Technology;TFF1 gene;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissue Sample;Tissues;transcription factor;Transcriptional Regulation;translational potential;translational study;Treatment Efficacy;tumorigenesis;tumorigenic;United States;Work;World Health Organization

PROJECT_TITLE: Molecular Pathobiology of Gastric Carcinogenesis


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: OVERALL: PROJECT NARRATIVE Recognizing that one of the greatest areas of need for pancreatic cancer patients is the rapid translation of therapies to the clinic, our Tissue Procurement, Pathology, and Genomics Core and Integrative Quantitative Sciences Core work seamlessly with the projects to process and analyze data from each of the projects and for the Selective Targeting of Pancreatic (SToP) Cancer SPORE as a whole. Thus the foremost goal of our SToP Cancer SPORE is to establish a new paradigm for clinical trial design based on cutting edge research that is not isolated to a single therapy or biomarker.

PI_NAMEs: YEH, JEN JEN  (contact)

PROGRAM_OFFICER_NAME: NOTHWEHR, STEVEN F

PROJECT_TERMS: Address;Advocate;aging population;Area;Biological Markers;biomarker identification;Cancer Etiology;career;Cellularity;Cessation of life;chemotherapy;chimeric antigen receptor T cells;Clinic;clinical biomarkers;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Colorectal Cancer;combinatorial;Complex;Consensus;Consent;Data;Dedications;design;Desmoplastic;Development;Diagnosis;Disease;early phase clinical trial;effector T cell;Environment;Environmental Risk Factor;Epigenetic Process;Etiology;Frequencies;Gene Mutation;Generations;Genetic;Genomics;Goals;Immunosuppression;Incidence;individualized medicine;Industry;innovation;Institution;International;KRAS2 gene;Lead;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;multidisciplinary;Mutation;Myeloid-derived suppressor cells;Names;Neoadjuvant Therapy;neoplastic cell;next generation;novel;novel therapeutics;oncology trial;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathology;Patients;Pilot Projects;Population;pre-clinical;precision oncology;Prevalence;Process;programs;recruit;Research;research and development;Research Personnel;Sampling;Science;Solid Neoplasm;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Time;Tissue Procurements;Tissues;translational goal;Translational Research;translational scientist;translational therapeutics;Translations;tumor;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Work

PROJECT_TITLE: Selective Targeting of Pancreatic Cancer SPORE


PHR: Public Health Relevance  Our immediate goal is to develop a tool for quantitative, high-speed endoscopy via anatomic optical coherence tomography (aOCT) that eliminates radiation exposure for evaluation of infants and children with subglottic stenosis, a life-threatening upper airway disorder. The tool will be developed as part of an individualized pipeline to model each subject’s airway, simulate surgery, and predict surgical outcomes to better inform surgical decision-making. Our long-term goals are to validate this approach clinically at multiple institutions, to evaluate the ability of these methods to improve outcomes, and to extend our methods to study other common airway diseases in children and adults.

PI_NAMEs: OLDENBURG, AMY L (contact);ZDANSKI, CARLTON J

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Adult;Affect;Air;Air Movements;Airway Disease;airway obstruction;Anatomy;Atlases;Bronchoscopes;Bronchoscopy;Catheters;Cessation of life;Child;Childhood;Cine CT;Clinical;computational pipelines;Data;Decision Making;deep learning;Development;Disease;elastography;Endoscopy;Enrollment;Evaluation;evidence base;experimental study;Failure;Family suidae;Foundations;Four-dimensional;Geometry;Goals;Growth;healing;Hypoxia;Image;imaging capabilities;imaging modality;Imaging technology;improved;improved outcome;in vivo;Infant;Infrastructure;Institution;Ionizing radiation;Lasers;Life;Liquid substance;Location;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;Multicenter Studies;novel;Obstructive Sleep Apnea;Operative Surgical Procedures;Optical Coherence Tomography;Outcome;outcome prediction;Output;Patients;Pattern;Phase;Physiological;Population;Postoperative Period;pre-clinical;Prediction of Response to Therapy;pressure;Property;prospective;public health relevance;quantitative imaging;Radiation;Radiation exposure;Resistance;Resolution;Respiration;respiratory;respiratory imaging;Respiratory Insufficiency;Risk;Scanning;Signal Transduction;Speed;Stenosis;Structure;success;surgery outcome;Surgical Models;Testing;Time;Tissue Model;tool;Treatment Failure;Treatment outcome;treatment planning;ventilation;virtual;viscoelasticity;Vision

PROJECT_TITLE: Predicting the Need for Surgery in Pediatric Subglottic Stenosis using Airway Elastography Derived from Endoscopic OCT and Intraluminal Pressure Measurement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: CORE A: PROJECT NARRATIVE The Administration Core (Core A) is essential for leading the Selective Targeting of Pancreatic (SToP) Cancer SPORE. Core A will provide scientific, financial and administrative oversight for all SPORE activities and make critical decisions regarding oversight and management of projects and cores.

PROJECT_TERMS: Advocacy;Advocate;anti-cancer research;Basic Science;cancer care;career;career development;Clinical;Clinical Trials;Collaborations;Communication;Consultations;cost effective;Data;Development;Disease;Disputes;Elements;Ensure;Evaluation;Faculty;Foundations;Fund Raising;Funding;Grant;Human Subject Research;Infrastructure;Institution;International;Leadership;Malignant neoplasm of pancreas;meetings;Mentorship;Minority;Monitor;National Cancer Institute;new technology;Occupational activity of managing finances;operation;outreach;Patients;Pilot Projects;Population;Privatization;Program Evaluation;Program Research Project Grants;programs;Publications;recruit;Regulation;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Series;Strategic Planning;Talents;timeline;translational cancer research;Translational Research;translational scientist;United States National Institutes of Health;Universities;website development;Work

PROJECT_TITLE: SToP Cancer SPORE: Administrative Core A


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT 1: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS-dependent tumorigenic growth. We recently determined that the treatment of PDAC with inhibitors of the key KRAS effector pathway, the RAF-MEK- ERK mitogenic activated protein kinase cascade, unexpectedly caused further elevation of the metabolic process autophagy, rendering PDAC acutely dependent on autophagy, and hypersensitive to autophagy inhibition. We propose studies to facilitate further clinical advancement of novel combination anti-autophagy strategies with the goal of identifying effective treatments for PDAC.

PI_NAMEs: DER, CHANNING J. (contact)

PROJECT_TERMS: Acute;advanced pancreatic cancer;Aftercare;anti-tumor immune response;arm;Automobile Driving;Autophagocytosis;Biological Markers;Biopsy;BRAF gene;cancer cell;Caring;Cells;Chronic;Clinical;clinical efficacy;Clinical Trials;Combined Modality Therapy;CRISPR/Cas technology;cytokine;Cytostatics;cytotoxic;cytotoxicity;Development;Eating;effective therapy;effectiveness evaluation;Evaluation;experimental study;Future;gemcitabine;Gene Expression;Genes;Genetic;genetic profiling;Genome;Genomic Library;Glycolysis;Goals;Growth;Growth Inhibitors;Hydroxychloroquine;Immune;Immune response;Impairment;improved;inhibition of autophagy;inhibitor;innovation;KRAS2 gene;loss of function;macromolecule;Malignant neoplasm of pancreas;Malignant Neoplasms;MEK inhibition;MEKs;Metabolic;Metabolism;Mitochondria;Mitogen-Activated Protein Kinases;Modeling;mouse model;Mus;mutant;Mutation;Normal tissue morphology;novel;Nutrient;Oncology;Organelles;Organoids;Paclitaxel;Pancreas;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;phase 2 study;Phase II Clinical Trials;Phenocopy;Pre-Clinical Model;Process;Protein Kinase;Publishing;Randomized;Recycling;research clinical testing;Resistance;resistance gene;resistance mechanism;response;response biomarker;Signal Transduction;small molecule libraries;Source;standard of care;targeted treatment;therapeutic target;therapeutically effective;Toxic effect;tumor;tumorigenic;Up-Regulation

PROJECT_TITLE: Project 1: Targeting autophagy for the treatment of KRAS-mutant PDAC


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Interstitial Cystitis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Urologic Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it seeks to establish the efficacy of an innovative and scalable intervention to addresses two prevalent and debilitating conditions, falls and urinary incontinence, which together affect 1 in 2 older adult women. Successful completion of this project has the potential to significantly decrease the substantial morbidity that results from these two conditions in community-dwelling women and thus is relevant to the NIH’s mission to enhance health and reduce disability.

PI_NAMEs: ANDY, UDUAK UMOH (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;Admission activity;Adult women;Affect;Age;Aging;Anti-Cholinergics;Anxiety;anxiety reduction;Attitude;Behavioral;Biological Markers;Bladder;Bladder Control;Clinical effectiveness;Communities;community engaged approach;comparison control;Consultations;Control Groups;Dependence;diaries;Dimensions;disability;Education;Educational Intervention;effective intervention;Effectiveness;efficacy testing;Elements;Environmental Hazards;Equilibrium;Exercise;exercise intervention;experience;Extravasation;Fall prevention;fall risk;falls;Fracture;Functional dependence;Goals;Hazard Assessment;Health;high risk population;Home;improved;Incontinence;innovation;International;Intervention;Life;Link;Lower Extremity;marginalized population;Measures;men;Mental Depression;micturition urgency;Minority;Minority Women;Mission;Modeling;Morbidity - disease rate;muscle strength;novel;Nursing Homes;older adult;older women;Outcome;Patients;Pharmaceutical Preparations;Physical environment;Physical Exercise;Pilot Projects;Prevention;preventive intervention;primary outcome;programs;Psyche structure;Public Health;Qualifying;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;Role;secondary outcome;Shame;social expectations;Social isolation;social stigma;Stroke;Symptoms;Techniques;Testing;Training;United States National Institutes of Health;Urban Community;Urinary Incontinence;Urine;Woman

PROJECT_TITLE: An integrated exercise and bladder training intervention to reduce falls in older women with urinary incontinence

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Coronaviruses;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: In this grant we will structurally characterize HIV-1 glycan shield targeting Fab-dimerized glycan reactive (FDG) antibodies. The overall goals of this study are to define atomic level structures of novel FDG antibodies in complex with their HIV-1 Env epitopes, to elucidate the structural determinants of FDG antibody evolution, and to determine the structural basis for FDG antibody recognition of diverse Coronavirus (CoV) spikes.

PI_NAMEs: ACHARYA, PRIYAMVADA  (contact);WILLIAMS, WILTON B

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Affinity;Amino Acid Substitution;Antibodies;Antigens;Architecture;arm;Avidity;B-Cell Development;Binding;Biological;Biology;Complex;Coronavirus;Coronavirus spike protein;cross reactivity;Cryoelectron Microscopy;design;Dimerization;Discrimination;Disulfide Linkage;Epitopes;Evolution;expectation;experimental study;glycosylation;Goals;Grant;HIV Infections;HIV-1;Human;Hydrogen Bonding;Hydrophobicity;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunologics;innovation;insight;Invaded;Macaca;Middle East Respiratory Syndrome Coronavirus;Molecular Conformation;mutant;natural antibodies;Negative Staining;neutralizing antibody;novel;pathogen;Polysaccharides;Population;Property;Proteins;Resolution;response;SARS coronavirus;SARS-CoV-2 spike protein;Shapes;simian human immunodeficiency virus;structural determinants;Structure;sugar;Variant;X-Ray Crystallography

PROJECT_TITLE: Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

PHR: PROJECT 2: PROJECT NARRATIVE We have had success in treating patients with hematological malignancies by using their own immune cells modified with a chimeric molecule that eliminates tumor cells but spare part of the immune B-lymphocytes. We are now extending this approach to solid tumors such as pancreatic cancer that remains a tumor with poor prognosis. In this project we intend test in a Phase I clinical trial the safety, persistence and in vivo functionality of these cells that have been modified to persist target an antigen expressed by pancreatic cancer cells.

PI_NAMEs: DOTTI, GIANPIETRO  (contact)

PROJECT_TERMS: Address;Adverse event;Antibodies;Antibody Specificity;Antigen Targeting;Antigens;B lymphoid malignancy;B-Lymphocytes;Biological Availability;cancer cell;cancer type;Caspase;CD19 Antigens;CD276 gene;Cell Physiology;Cell surface;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;Cross Reactions;Data;Desmoplastic;Dose Limiting;effector T cell;Endoplasmic Reticulum;Engineering;Enzymes;Epitopes;Evaluable Disease;Evaluation;extracellular;Extracellular Matrix;Family;first-in-human;Genetic;glucose-regulated protein 94;Goals;Growth;Heat-Shock Proteins 90;Hematologic Neoplasms;Heparan Sulfate Proteoglycan;heparanase;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunocompetent;immunosuppressive macrophages;Immunotherapy;In Vitro;in vivo;Infiltration;Infusion procedures;inhibitor;Integral Membrane Protein;Invaded;leukemia;Macrophage;Malignant Breast Neoplasm;Malignant lymphoid neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Melanoma;member;Molecular Chaperones;Molecular Conformation;mouse model;Mus;Myelogenous;Myeloid-derived suppressor cells;Nature;neoplastic cell;Normal tissue morphology;North Carolina;novel;Oral;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;patient prognosis;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;Penetration;Phase;phase 1 study;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Prognosis;programs;Proteins;Reaction;receptor expression;Receptor Protein-Tyrosine Kinases;Refractory;Reporting;response;Safety;safety assessment;Shapes;Signal Transduction;small molecule inhibitor;Solid Neoplasm;success;suicide gene;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Toxic effect;tumor;Tumor Escape;tumor microenvironment;Tumor Promotion;tumorigenesis;tumorigenic;Universities

PROJECT_TITLE: Project 2: Combined CAR-T cell therapy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Disability Research;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Regenerative Medicine;Rehabilitation;Spina Bifida;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Spina bifida (SB) is the most common cause of lifelong childhood paralysis, which results from the incomplete closure of the neural tube and overlying spine during fetal development. Patients require life-long treatment as they navigate lifelong paralysis, cognitive disabilities, musculoskeletal deformities, and bowel and bladder dysfunction. We aim to develop a novel engineered hydrogel system for local and sustained neuroprotection to be used in conjunction with a bone scaffold, thus resulting in an optimal combination scaffold as a long-term therapy for the in utero treatment of SB.

PI_NAMEs: FARMER, DIANA LEE (contact);WANG, AIJUN

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Achievement;Animal Model;Animals;Binding;Biocompatible Materials;biodegradable polymer;Biomedical Engineering;bioscaffold;Birth;Bladder Dysfunction;bone;Bone Diseases;Bone Regeneration;bone scaffold;Caring;Cell Communication;Cells;Chemical Injury;Child;Childhood;Clinical;Clinical Trials;cognitive disability;Collagen;Defect;Deformity;density;design;Disease;dosage;embryo surgery;Engineering;Environment;exosome;experimental study;Exposure to;extracellular vesicles;fetal;Fetal Development;Fetal Sheep;Fetal Tissues;functional group;Glycolic-Lactic Acid Polyester;Goals;Growth;Health Care Costs;hindbrain;Human;Hydrogels;Hydroxyapatites;Immobilization;improved;in utero;In Vitro;in vivo;independent ambulation;Intestines;Kyphosis deformity of spine;Limb structure;Longevity;mechanical properties;Mechanics;Meningomyelocele;Mesenchymal Stem Cells;Methods;Modeling;Molecular;Molecular Weight;Morbidity - disease rate;Motor;Muscle;Musculoskeletal;Neural Tube Closure;Neurodegenerative Disorders;neuroprotection;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Oryctolagus cuniculus;Osteogenesis;Outcome;paracrine;Paralysed;Patients;Peptides;Physical therapy;Placenta;Play;postnatal;pre-clinical;prenatal therapy;prevent;Preventive care;Quality of life;Recovery of Function;regeneration function;regeneration potential;regenerative;regenerative therapy;Regimen;repaired;Rodent;Role;scaffold;sheep model;Speed;Spinal Cord;spinal cord compression;Spinal cord injury;Spinal Dysraphism;standard of care;stem cell exosomes;Surface;System;Testing;Therapeutic;Therapeutic Uses;Transplantation;Trauma;United States;United States National Institutes of Health;Vertebral column;Walking

PROJECT_TITLE: Engineered Neuroprotective Stem-Cell Exosomes for In Utero Spina Bifida Therapy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: Three redundant proteins, the YTHDF proteins, share the unique function to degrade mRNAs marked with a specific chemical modification called m6A. However, it’s been challenging understanding how this process is regulated. Using innovative technologies, I propose to study how these YTHDF proteins are dynamically regulated to control the degradation of m6A-marked mRNAs and the impact of this mechanism in hematopoietic stem cells differentiation.

PI_NAMEs: ZACCARA, SARA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affect;Amino Acids;Biological Assay;Cell Fate Control;cellular engineering;Chemicals;Code;CRISPR/Cas technology;Data;Defect;Ensure;Event;experimental study;Gene Expression Profile;Goals;hematopoietic differentiation;hematopoietic stem cell differentiation;Hematopoietic stem cells;Impairment;In Vitro;in vivo;innovative technologies;Knock-out;Maps;Measurement;Mediating;Mediator;Messenger RNA;Methylation;mimetics;Modeling;Modification;Monitor;mRNA Expression;mRNA Instability;mRNA Stability;mRNA Transcript Degradation;Mus;mutant;Nucleotides;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Population;Positioning Attribute;Process;Protein Dynamics;Proteins;Reading;Regulation;response;Role;Signal Pathway;single-cell RNA sequencing;Site;stem cell differentiation;Testing;Time;transcriptome;Work;Writing

PROJECT_TITLE: The DF phospho-code regulating the degradation of m6A mRNA


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

PHR: PROJECT 3: PROJECT NARRATIVE Leveraging the strengths of molecular subtyping expertise and neoadjuvant therapy infrastructure, we propose a pilot substudy where PurIST subtype will be used to direct the initial chemotherapy supported from the retrospective analyses of two prior trials where the basal-like subtype is resistant therapy. To our knowledge this will be the first trial to use molecular subtyping to direct treatment in the neoadjuvant setting.

PROJECT_TERMS: Aftercare;alternative treatment;Biological Assay;Biopsy;Cancerous;Cells;Cellularity;Characteristics;chemotherapy;Classification;CLIA certified;Clinic;Clinical;clinical infrastructure;Clinical Trials;Coculture Techniques;cohort;combinatorial;Computing Methodologies;Consensus;Data;Data Set;Desmoplastic;Devices;differential expression;Ecosystem;Effectiveness;Epidermal Growth Factor Receptor;Evaluation;Fibroblasts;gemcitabine;Genes;Immune;Immunooncology;improved outcome;Infrastructure;inhibitor;innovation;kinase inhibitor;KPC model;Letters;Libraries;Light;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Mass Spectrum Analysis;medical schools;Methodology;Methods;molecular subtypes;nano-string;Neoadjuvant Therapy;Normal Cell;North Carolina;novel;novel strategies;Organoids;Outcome;Paclitaxel;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;patient derived xenograft model;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phosphotransferases;Physicians;precision oncology;predicting response;Prediction of Response to Therapy;programs;prospective;Proteins;Proteomics;Regimen;Resistance;response;Risk;Sampling;Selection for Treatments;Signal Transduction;single-cell RNA sequencing;Therapeutic;therapy resistant;transcriptomics;Treatment outcome;treatment response;tumor;tumor microenvironment;Tumor Subtype;Universities;Validation;Wisconsin

PROJECT_TITLE: Project 3: Transcriptomic subtypes, response predictions, and therapy selection


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE MDM2 and its numerous isoforms are key regulators of the expression and function of the p53 gene, a critical tumor suppressor that prevents inappropriate cell growth and proliferation. The proposed research will study the molecular connection between DNA damage, MDM2 isoform switching, p53, and cancer. Unraveling this pathway could lead to the discovery of novel therapeutic intervention points and thus be a crucial stepping-stone for cancer drug discovery.

PI_NAMEs: CHANDLER, DAWN S (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adult;Alanine Transaminase;Alternative Splicing;Antineoplastic Agents;Astrocytoma;Automobile Driving;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biology;Biophysics;Breast;Cancer Biology;cancer therapy;cancer type;cell growth;Cell Line;Cell Proliferation;cell type;Cells;Cellular Stress;Chemistry;chemotherapeutic agent;Childhood Glioma;combinatorial;Complex;Coupled;Data;design;Disease;DNA Damage;Dominant-Negative Mutation;drug discovery;Engineering;Event;Excision;exon skipping;Exons;Future;gene-editing approach;Generations;Genetically Engineered Mouse;Genome;Genotoxic Stress;genotoxicity;Glioma;Goals;High-Throughput Nucleotide Sequencing;Human;In Vitro;industry partner;Knowledge;Length;liposarcoma;Lung;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;MDM2 gene;Measures;Mechanics;Mediating;Methodology;Methods;MicroRNAs;Modality;Modeling;Molecular;mouse model;mRNA Precursor;Mus;Mutation;novel;novel therapeutic intervention;Nuclear;Nuclear Protein;Nuclear RNA;Oligonucleotides;Oncogenic;Outcome;Ovary;overexpression;Pathway interactions;Pharmacologic Substance;Phenotype;Play;Positioning Attribute;prevent;Primary Neoplasm;Property;Protein Isoforms;Proteins;Publishing;Regulation;Regulatory Element;Repression;Research;response;Rhabdomyosarcoma;RNA;RNA Biochemistry;RNA metabolism;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Stress;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy design;TP53 gene;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Variant;Viral;Work;Xenograft procedure

PROJECT_TITLE: Mdm2 Alternative Splicing in DNA Damage and Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: CORE B: PROJECT NARRATIVE The Tissue Procurement, Pathology, and Genomics (TPPG) Core will assist SPORE projects with expertise and guidance in pathology, genomics, and data analysis and will provide investigators with research specimens and clinical data. TPPG will provide database support for collecting, tracking, and distributing data and will ensure rigor, reproducibility, and transparency within all SPORE projects.

PI_NAMEs: IUGA, ALINA  (contact)

PROJECT_TERMS: analysis pipeline;Bioinformatics;Cellularity;Clinical;Clinical Data;Clinical Laboratory Information Systems;Code;Collaborations;Collection;Comprehensive Cancer Center;computer cluster;Core Facility;Data;Data Analyses;data de-identification;data management;data sharing;Data Storage and Retrieval;Databases;Development;distributed data;DNA;DNA sequencing;Doctor of Philosophy;Ensure;Environment;Evaluation;Fostering;genomic data;Genomics;Histologic;Hospitals;improved;Infrastructure;Laboratories;Leadership;Link;Malignant neoplasm of pancreas;Management Information Systems;Methods;Normal tissue morphology;Pancreas;pancreatic cancer patients;Pathologic;Pathology;Process;Proteins;public repository;Reproducibility;Research Activity;Research Personnel;Resource Sharing;RNA;sample collection;Sampling;Science;Services;Specimen;System;Technology;Tissue Banks;Tissue Procurements;Tissues;transcriptome sequencing;Translational Research;Tumor Tissue;Update

PROJECT_TITLE: Core B - Tissue Procurement, Pathology, and Genomics


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE AIDS is one of the largest pandemics in history that remarkably, in the 40 years since its first description, the etiologic agent was identified, accurate tests to detect its presence were created, and over 30 novel drugs developed. This has turned a universally fatal disease into a chronic, manageable condition. Owing to the rapid emergence of both the disease and its treatment, many unanswered questions regarding the long-term outcomes of patients remain proving that ongoing research is needed to help answer these questions.

PI_NAMEs: SAAG, MICHAEL S. (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adjudication;analytical method;antiretroviral therapy;Area;Behavioral Research;Biological;Biological Specimen Banks;Biostatistics Core;Cardiac;career;Caring;Chronic;Clinic;Clinical;clinical care;Clinical Data;Clinical Management;clinical training;clinically relevant;cohort;Collection;Communities;comorbidity;Complex;Concept Review;Consultations;cost;COVID-19;Data;Data Collection;data interoperability;data management;data repository;Data Science;Data Set;Dedications;Development;Disease;Disease Progression;Drug resistance;Electronic Health Record;electronic health record system;epidemiologic data;Epidemiology;epidemiology study;Etiology;Event;experience;FAIR principles;Foundations;Funding;Genetic;Health;HIV;improved;Individual;Intervention;Kidney;Knowledge;Life;life span;Link;Liver;Measurement;Mentors;Mission;Modernization;neoplastic;Neurocognitive;North Carolina;novel;novel therapeutics;Outcome;pandemic disease;Pathogenesis;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Peer Review;Personal Satisfaction;Persons;point of care;Policies;Policy Maker;Process;programs;R24;Randomized;Recording of previous events;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Resources;RNA;sample collection;Sampling;Science;Scientist;Site;Social Behavior;Source;Specimen;Strategic Planning;success;System;Testing;Translational Research;United States National Institutes of Health;Virus;Washington

PROJECT_TITLE: CFAR Network of Integrated Clinical Systems (CNICS)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Patient Safety;Precision Medicine;Rare Diseases

PHR: CORE C: PROJECT NARRATIVE The Integrated Quantitative Sciences Core participates in the design of all clinical trials, animal studies, and translational research proposed in the SPORE to ensure that all relevant studies are well powered, utilize appropriate statistical methods, and are properly designed to address relevant hypotheses of study aims. In this manner the Core supports the rigor and reproducibility of all results that are generated by the SPORE, which in turn has significant impacts in the fields of public health and medicine. Expert analysis of project data and clear reporting of scientific results are of similar importance for addressing scientific hypotheses and similarly have strong implications in public health.

PI_NAMEs: KOSOROK, MICHAEL R (contact)

PROJECT_TERMS: Address;analytical tool;Animals;Applications Grants;biomarker discovery;Biometry;career development;Characteristics;Clinical;Clinical Data;clinical decision-making;Clinical Protocols;Clinical Trials;Clinical Trials Design;Data;data integration;data management;data platform;database design;design;Development;diverse data;Documentation;Ensure;Faculty;Future;Gene Expression Profiling;genomic data;genomic platform;Genomics;high dimensionality;Human;Individual;individual patient;innovation;machine learning method;Maintenance;Malignant neoplasm of pancreas;Medicine;Methodology;Methods;Mission;Molecular;multiple data types;Outcome;Participant;Pathology;patient response;patient subsets;Portraits;Preparation;Program Development;Proteomics;Public Health;Publications;Quality Control;Reporting;Reproducibility;Research Design;Research Personnel;Research Project Grants;research study;response;Sample Size;Science;Services;skills;Statistical Data Interpretation;Statistical Methods;Technical Expertise;Time;Tissue Procurements;Translational Research;treatment response;treatment strategy;tumor

PROJECT_TITLE: Core C - Integrated Quantitative Science (IQS)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

PHR: DEVELOPMENTAL RESEARCH PROGRAM: PROJECT NARRATIVE The Developmental Research Program of the UNC Pancreatic Cancer SPORE supports developmental research into causes and treatment of pancreatic cancer. Announcements for funding will be widely distributed to all UNC faculty and to partner institutions. Evaluation of projects will be performed by the DRP review committee.

PI_NAMEs: BALDWIN, ALBERT SIDNEY (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Award;Basic Cancer Research;Biomedical Engineering;Budgets;cancer cell;Cancer Control;cancer imaging;cancer prevention;cancer therapy;career;career development;Cellular biology;Clinical Research;Collaborations;Development;drug development;Early Diagnosis;Early treatment;Epigenetic Process;Evaluation;experience;Extramural Activities;Faculty;flexibility;Foundations;Funding;Genetic;Goals;Historically Black Colleges and Universities;Immunology;Immunotherapy;improved outcome;Incidence;innovation;insight;Institution;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;Mission;Modeling;Monitor;mortality;North Carolina;novel therapeutic intervention;Pancreas;Participant;Peer Review;Population Research;Population Study;pre-clinical;Program Research Project Grants;Program Reviews;programs;Publications;Research;Research Personnel;Research Support;Resources;Review Committee;Signal Transduction;Sister;success;Technology;Testing;Therapeutic;Time;translational goal;translational potential;Translational Research;tumor immunology;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: SToP Cancer SPORE: Developmental Research Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative The Transfusion of Prematures (TOP) Trial randomized 1,824 preterm infants to liberal or restrictive red blood cell transfusions in order to determine which practice might be best for neurodevelopmental outcomes at 2 years. The current “TOP 5 Study” will assess functional neurodevelopmental outcomes of TOP subjects at 5 years of age, an age which will permit detailed assessment of cognitive skills, motor coordination, emotional/behavioral development, and academic readiness. Evaluating which approach to transfusion minimizes damage to vulnerable neuronal circuits is expected to have a significant impact on the clinical management of preterm infants and, in turn, improve both short and long-term outcomes for premature infants.

PI_NAMEs: DAS, ABHIK  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 5 year old;academic preparation;Academic skills;Age;Age Months;Anemia;Behavioral;Biometry;Birth Weight;Brain;Caring;Child;Childhood;Clinical;clinical center;Clinical Management;clinical practice;Clinical Research;Cognitive;cognitive function;cognitive skill;cohort;Cohort Studies;Collaborations;Companions;Data;Data Coordinating Center;data management;data quality;Data Reporting;Data Set;design;Development;electronic data capture system;Emotional;Enrollment;Ensure;Erythrocyte Transfusion;Event;evidence base;experience;Exposure to;extreme prematurity;Extremely Low Birth Weight Infant;Family;flexibility;follow-up;Follow-Up Studies;functional outcomes;Funding;Gestational Age;Goals;Hemoglobin;Hemoglobin concentration result;Home environment;Human Resources;Impairment;improved;Infant;infant outcome;Information Dissemination;Informed Consent;Infrastructure;Institution;Intensive Care Units;International;Knowledge;Lead;Leadership;Learning Disabilities;Letters;Life;Longterm Follow-up;Low Birth Weight Infant;Manuals;meetings;Mental disorders;Monitor;Morbidity - disease rate;Motor;Multicenter Neonatal Research Network;Multicenter Studies;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;Neonatology;Network Infrastructure;neurodevelopment;Neurodevelopmental Impairment;Neurologic;Neurological outcome;neuronal circuitry;Newborn Infant;Outcome;Outcome Study;Outcomes Research;Parents;Patients;payment;Performance;Phase;Population;premature;Premature Infant;Principal Investigator;Process;Productivity;Protocols documentation;Qualifying;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Records;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Running;Safety;Sample Size;school environment;School-Age Population;skills;Statistical Data Interpretation;Structure;success;System;Time;tool;Training;Transfusion;United States National Institutes of Health;Update;Visit

PROJECT_TITLE: Transfusion of Prematurity Early School Age Follow-up (TOP 5) DCC

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


PHR: CAREER ENHANCEMENT PROGRAM: PROJECT NARRATIVE The Career Enhancement Program of the UNC Pancreatic cancer SPORE prepares the next generation of translational pancreatic cancer researchers.

PI_NAMEs: SERODY, JONATHAN S. (contact)

PROJECT_TERMS: Advisory Committees;Advocate;African American;anti-cancer research;Area;Award;Basic Science;career;career development;Clinic;Clinical;Clinical Investigator;Clinical Sciences;Collaborations;Communities;Comprehensive Cancer Center;Diagnosis;Disabled Persons;Doctor of Philosophy;Early Diagnosis;Faculty;Female;Financial Support;Fostering;Funding;Funding Mechanisms;Goals;Grant;Historically Black Colleges and Universities;Immunology;improved outcome;Individual;Institution;Jordan;Laboratories;Latino Population;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;member;Mentors;Microbiology;Minority;next generation;North Carolina;Pancreas;pancreatic cancer patients;Patient Care;Patients;Pediatric Surgical Procedures;Peer Review;Population Sciences;Postdoctoral Fellow;Prevention;Process;professor;programs;Public Health;Qualifying;recruit;Research;Research Personnel;Resources;standard care;Students;success;Teacher Professional Development;Translating;translational pipeline;translational progress;Translational Research;translational scientist;Underrepresented Minority;Underrepresented Populations;Universities;Vocational Guidance;Woman;Work;Writing

PROJECT_TITLE: SToP Cancer SPORE: Career Enhancement Program


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: This study will demonstrate the efficacy of a perturbation training intervention to reduce postoperative falls after total knee arthroplasty. Osteoarthritis is a risk factor for preoperative and postoperative falls and people with endstage osteoarthritis undergoing joint replacement are at particular risk for injurious falls. The proposed research is relevant to public health because falls are a major public health issue for older adults, including the over 750,000 who receive total knee arthroplasty each year.

PI_NAMEs: FOUCHER, KHARMA CHARISSE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adult;Aging;Amputees;clinical care;Clinical Trials;Communities;Degenerative polyarthritis;Education;Educational Intervention;Effectiveness;experience;fall injury;Fall prevention;fall risk;falls;Gait;Goals;Growth;Habilitation;Hospitalization;improved;Incidence;Injury;innovation;Intervention;kinematics;Knee Osteoarthritis;knee replacement arthroplasty;Laboratories;Literature;Lower Extremity;Measures;Mechanics;Medical Care Costs;Methods;middle age;Motor Skills;older adult;older women;Operative Surgical Procedures;patient population;Patients;Perioperative;Persons;Physical activity;Pilot Projects;Population;Postoperative Period;prevent;Prevention education;prospective;Protocols documentation;Public Health;Qualifying;Randomized;Recovery;Replacement Arthroplasty;Research;response;Risk;Risk Factors;Risk Reduction;Schedule;secondary endpoint;Step training;strength training;success;Techniques;Testing;Time;Training;With laterality;Woman;Work;Writing

PROJECT_TITLE: Preoperative perturbation training to prevent falls after total knee arthroplasty

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Diacetyl is a highly toxic chemical found in many foods and drinks. When inhaled, this chemical is known to cause debilitating lung disease, currently with no FDA-approved treatment. This proposal will critically examine the role of airway stem cells in diacetyl-induced lung disease in order to identify new therapies.

PI_NAMEs: MCGRAW, MATTHEW DANIEL (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Adult;Affect;Air;Airway Disease;airway epithelium;Basal Cell;Biological Assay;Biology;Body Weight decreased;Bortezomib;Bronchiolitis Obliterans;career development;Cell Differentiation process;cell injury;Cell Physiology;Cell Proliferation;Cells;chemical addition;chemical association;Chemical Exposure;Chemical Models;Chemicals;Child;Clinical;Coffee;comparative efficacy;Complement;cytotoxicity;Data;Development;Diacetyl;diketone;Disease;Doctor of Philosophy;Drug Targeting;Electronic cigarette;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;Etiology;Exposure to;FDA approved;fibrotic lung disease;Flavoring;Food;Functional disorder;Future;Histologic;Hour;Human;Hypoxemia;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vitro Model;in vivo Model;Inhalation;Inhalation Exposure;Inhalation Toxicology;injured;injured airway;Injury;International;Lead;Lesion;Liquid substance;Lung;Lung Diseases;Mediating;Medical center;Mentors;Modeling;multicatalytic endopeptidase complex;novel therapeutics;Occupational;Organ Transplantation;overexpression;Oxygen;Pathogenesis;Pathway interactions;Physicians;Poison;Pre-Clinical Model;preservation;prevent;Proliferating;Proteasome Inhibition;Proteins;Proteomics;proteotoxicity;Rattus;Recovery;Red Cross;repaired;reparative capacity;Research;Respiratory Tract Infections;Role;Scientist;small airways disease;stem cell biology;stem cells;Stress;Stromal Cells;System;Testing;therapeutic development;Time;Toxic effect;Training;Ubiquitin;Universities;vapor;Virus;Weight Gain

PROJECT_TITLE: Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis Obliterans


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The human immune system has evolved in response to selective pressures exerted by a range of viral pathogens. This project aims to determine the role of herpes simplex viruses in influencing and adapting to evolutionary changes in the host cell antiviral protein MxB. More generally, the results of these experiments will contribute to our understanding of the risks and barriers to cross species viral transmission events.

PI_NAMEs: GEBALLE, ADAM P. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;African;African American population;Alleles;arm;arms race;Biochemical;Biological Assay;Biotinylation;candidate identification;Capsid;Cebidae;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;cofactor;Complement;Coupled;Cytomegalovirus;Data;Development;Double Stranded DNA Virus;Event;Evolution;Experimental Genetics;experimental study;Genes;Genetic Determinism;Genetic Polymorphism;genetic signature;Genome;genome editing;Genomics;Goals;Health;Herpesviridae;Herpesvirus 1;Human;Human Herpesvirus 2;Immune;Immune system;Immunologic Factors;Infection;insight;Integration Host Factors;Interferons;Investigation;Ligation;Maps;Mass Spectrum Analysis;Measures;Mediating;Modeling;Molecular;nonhuman primate;nonsynonymous mutation;Nuclear Import;Orthologous Gene;Pan Genus;pathogen;pathogenic virus;Phenotype;Play;Population;pressure;Primates;protein B;protein Mx;Protein Truncation;resistance gene;resistant strain;response;Risk;Role;Sequence Analysis;Shapes;Side;Simplexvirus;Site;Species Specificity;Study models;System;Testing;Time;Variant;Viral;Viral Genome;Viral Physiology;Viral Proteins;viral transmission;Virus;Virus Diseases;virus genetics;Work

PROJECT_TITLE: Evolution and mechanism of restriction of herpesviruses by MxB


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Moshi

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: KILIMANJARO CHRISTIAN MEDICAL CENTRE

PHR: Narrative Every year, nearly 5 million people die from injuries and hundreds of millions more sustain non-fatal injuries that require medical attention with low and middle income countries (LMICs), accounting for 90% of all injury related deaths. This proposal will train 2 doctoral and 10 masters students and establish an injury research network to support access to quality trauma care in the region.

PI_NAMEs: MMBAGA, BLANDINA THEOPHIL (contact);STATON, CATHERINE ANN

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accounting;care systems;Caring;Collaborations;Evidence based intervention;Goals;Hospitals;implementation science;Injury;injury burden;injury-related death;innovation;Interdisciplinary Study;low and middle-income countries;medical attention;Medical center;Persons;programs;Quality of Care;rehabilitation service;Research;Research Personnel;SERPINI2 gene;Services;Students;System;Tanzania;Training;Training Programs;Trauma;trauma care;Trauma Research;Universities

PROJECT_TITLE: The TRECK Program: Trauma REsearch Capacity Building in Kilimanjaro, Tanzania