ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Microbiome;Neurosciences;Nutrition;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: This innovative study seeks to determine the role of dietary intake in supporting the growth of cognition- changing gut microbes and by-products that influence cognitive health in breast cancer survivors during receipt of chemotherapy. If proven correct, our study could provide compelling mechanistic evidence to explain how diet consumed during chemotherapy impacts the development or severity of cognitive impairment due to chemotherapy treatment in breast cancer survivors by modulating the gut microbiota and its products. The key outcomes include our first understanding of how diet and the gut microbiome impact the development or severity of cancer treatment-related cognitive impairment (CRCI), dietary or probiotic interventions designed to reduce incidence and severity of CRCI, and increased efforts to change local and nationwide policy to reimburse individuals with CRCI for the purchase of cognitively beneficial meals.

PI_NAMEs: MCLEOD, ANDREW P (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Adherence;Adjuvant Chemotherapy;Affect;Aftercare;arm;Attitude;Award;Bacteria;Bacterial Translocation;Behavior;Biological;Breast Cancer survivor;Breast Cancer Treatment;Butyrates;Calories;Cancer Patient;chemotherapy;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive process;cognitive testing;cohort;Complex;Consumption;Data;Data Analyses;Data Collection;Data Set;data submission;Delayed Memory;design;Development;Diagnosis;Diet;dietary;dietary approach;Dietary intake;Dietary Intervention;Eating;executive function;experience;Fatty acid glycerol esters;Feces;feeding;Fiber;Food;Fruit;Goals;Grant;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Impaired cognition;Impairment;improved;Incidence;Individual;Ingestion;innovation;Institution;Intake;Intervention;Interview;Learning;Link;lipopolysaccharide-binding protein;Malignant Breast Neoplasm;Measures;Mediating;Mediterranean Diet;Memory;Mentors;microbial;Modeling;monounsaturated fat;Neurologic;Neuropsychological Tests;Neuropsychology;novel;Occupations;Outcome;Participant;Patients;Pattern;Phase;Policies;Polyamines;Population;post intervention;preference;Prevalence;prevent;Probiotics;Quality of life;Randomized;Recipe;recruit;Research;Research Personnel;retention rate;Risk Factors;Role;Severities;Short-Term Memory;Side;Speed;standard care;Structure;systemic inflammatory response;Taste Perception;Testing;therapy design;Toxic effect;Training;treatment comparison;Treatment outcome;Treatment-Related Cancer;Unhealthy Diet;Vegetables

PROJECT_TITLE: The Gut Microbial and Dietary Origins of Cancer Treatment-Related CognitiveImpairment

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Natural Products;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

PHR: PROJECTIVE NARRATIVE High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic cancer with current treatment strategies including the naturally derived compound, Paclitaxel. Unfortunately, drug resistance to current therapies has led to relapse and eventually death in ovarian cancer patients. Combinatorial treatment of cytotoxic natural products didesmethyrocaglamide and phyllanthusmin34 as well as mechanism of action will be studied in vitro and in vivo as novel strategies for treating this deadly cancer.

PI_NAMEs: KAWEESA, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Accounting;Activated Natural Killer Cell;Aglaia;Allografting;Anti-tumor Natural Products;antitumor effect;Apoptosis;Apoptotic;ATP phosphohydrolase;Autophagocytosis;Award;Binding;Biological Availability;Breast Cancer gene;cancer cell;Cancer cell line;Cancer Etiology;Cancer Gene Mutation;Cancer Model;Cancer Patient;Canis familiaris;career;Cause of Death;Cell Death;Cell Death Induction;Cell Line;Cell Survival;Cells;Cessation of life;Chemoresistance;chemotherapy;Cisplatin;Clinic;Collaborations;combat;combinatorial;cytotoxic;cytotoxicity;Data;Development;Drug resistance;Drug usage;efficacy study;Eukaryotic Initiation Factor-4A;Exhibits;Faculty;Family;FDA approved;Fostering;Foundations;Goals;Half-Life;Immune response;improved;In Vitro;in vivo;ineffective therapies;inhibition of autophagy;inhibitor;insight;Interferons;Label;Laboratory Research;large scale production;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;marine;Microbe;Modeling;mouse model;mRNA Translation;multidisciplinary;nanomolar;Natural Compound;Natural Killer Cells;Natural Products;neoplastic cell;NK Cell Activation;novel;novel strategies;novel therapeutics;Outcome;Ovarian;Paclitaxel;Pathway Analysis;Patient Care;Pharmaceutical Preparations;pharmacologic;Phase;Phyllanthus;Plants;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;pre-clinical;Preclinical Testing;Prevalence;prevent;programs;Property;Protein Biosynthesis;protein expression;Protein Synthesis Inhibition;Proteins;Proteomics;Recycling;Relapse;Reporting;Research;Research Personnel;Resistance;response;RNA Binding;rocaglamide;Role;secondary metabolite;Serous;silvestrol;Source;taxane;Testing;Therapeutic;Training;Translating;Translations;treatment effect;treatment strategy;tumor;Tumor Burden;Tumor Debulking;Western Blotting;Women's mortality;women's treatment;Xenograft procedure

PROJECT_TITLE: Pharmacological Potential of Combined Translation and Autophagy Inhibition in High Grade Serous Ovarian Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Nicotine pouches and “non-menthol” cigarettes are new tobacco product categories with rapidly growing user populations. We found that the industry added artificial flavors to these products, including sweeteners and cooling chemicals. In our proposed study we will examine the content of flavors and sweeteners in these products, and test whether they make it easier to become addicted to nicotine.

PI_NAMEs: JORDT, SVEN-ERIC  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Address;Adolescent;Adult;Advertising;Air;Artificial Sweeteners;Behavior;Behavioral;Biological Assay;Blood;C57BL/6 Mouse;California;capsule;Categories;Characteristics;Chemicals;Chemistry;Cigarette;Consumption;Data;Databases;design;enantiomer;Engineering;Exposure to;Female;Female Adolescents;Filler;Flavoring;Formulation;Fruit;Industry;Intake;Intervention;irritation;Label;liquid chromatography mass spectrometry;male;Male Adolescents;Marketing;Mass Fragmentography;Massachusetts;Menthol;Mission;Modeling;Mus;Nicotine;Nicotine Dependence;nicotine inhalation;novel;Oral;Persons;Physiological;Plethysmography;Population;Powder dose form;preference;prevent;Public Health;Publishing;receptor;Research;Resources;respiratory;response;Risk;Sensory;Smoke;smoke inhalation;Smokeless Tobacco;Smoker;smoking cessation;smoking initiation;Surveys;sweet taste perception;Sweetening Agents;Taste Buds;Testing;Tobacco;Tobacco Industry;tobacco products;Tobacco smoke;tobacco-free;United States National Institutes of Health;United States National Library of Medicine;Wild Type Mouse;Work;Youth

PROJECT_TITLE: Impact of new tobacco product design and synthetic additives on use initiation and preference behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-E (56)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative The cancer substrates regulated by arginylation and subsequent degradation are largely unknown. This proposal aims to unbiasedly unveil the arginylation substrates and their sites in cancer cells and recruit ATE1 to achieve targeted protein degradation through arginylation-ubiquitination-degradataion cascade. The novel approach called arginylation targeting chimera (ArgTAC) holds full potential to be developed as cancer therapies.

PI_NAMEs: LIN, ZONGTAO  (contact);LYU, DONGWEN

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Acetylation;Amines;analytical method;Arginine;beneficiary;Binding;Bypass;cancer cell;Cancer cell line;cancer therapy;Cancerous;Catalogs;Cell Line;Cell model;Chimera organism;Computer Models;Coupling;Data;Dependence;design;Development;drug discovery;Enzymes;Eukaryota;Event;improved;interest;Isotope Labeling;Libraries;Ligands;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methods;Modality;Modeling;Modification;Molecular;Molecular Biology;Monoubiquitination;multicatalytic endopeptidase complex;N-terminal;Names;Neoplasm Metastasis;new technology;novel;novel strategies;Oncoproteins;Outcome;Pathway interactions;Peptides;Physiological;Play;Polyubiquitination;Proline;Protac;protein degradation;Protein Degradation Induction;Proteins;Proteome;Proteomics;Quality Control;RAD52 gene;recruit;Role;Sampling;screening;Series;Signal Pathway;Signal Transduction;Signaling Protein;Site;small molecule;Structure;success;System;Tacrolimus Binding Proteins;Technology;Testing;Therapeutic;Time;tool;tumor progression;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Hijacking Post-translational Arginylation for Targeted Protein Degradation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (M1)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Immunization;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: BRONX

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Recently, our lab developed a novel immune therapeutic approach delivering TT as a neoantigen surrogate into tumors by Listeria infection in vivo, which attracts pre-existing TT-specific memory T cells (generated earlier in life during childhood vaccinations) now killing the highly immunogenic tumor cells. Our ultimate goal is to test this promising therapy in patients with advanced PDAC. However, in contrast to all other Listeria-based therapies in patients, our Listeria needs to be injected intraperitoneally in order to reach tumors and metastases. This is completely new and requires extra precautions. Monitoring Listeria in vivo is such a precaution. Therefore, we have uploaded Listeria-TT with 18F-fluorodeoxyglucose (FDG) and demonstrated that this Listeria could be visualized in tumors and metastases by PET/CT. The main goal of this proposal is to finetune the Listeria-TT- FDG for human application.

PI_NAMEs: GRAVEKAMP, CLAUDIA  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;advanced pancreatic cancer;Age;Antigens;Attenuated;Bacteria;Biodistribution;Blood;Cancer Patient;CD4 Positive T Lymphocytes;Cells;Childhood;Clinical Trials;Diagnosis;diagnostic value;Dose;Enzymes;fluorodeoxyglucose;Gamma counter;gemcitabine;glucose analog;glucose transport;Glucose Transporter;Goals;Granzyme;hexokinase;Human;Immune;immune clearance;Immune system;immunogenic;Immunologics;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Incubated;Individual;Infection;inorganic phosphate;intraperitoneal;Intraperitoneal Injections;Intravenous;intravenous injection;KPC model;Life;Listeria;Listeria monocytogenes;Listeriosis;liver function;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurable;Measures;Methodology;Monitor;mouse model;multidisciplinary;Mus;Myeloid-derived suppressor cells;neoantigens;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel therapeutic intervention;Organ;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Pathologic;Patients;perforin;Phase I Clinical Trials;Phosphoenolpyruvate;Phosphorylation;Phosphotransferases;Positron-Emission Tomography;preclinical study;Publishing;Radioactive;Regimen;Route;Safety;Saline;Science;Signal Transduction;Starvation;statistics;success;System;T cell response;T memory cell;T-Lymphocyte;Testing;Tetanus Toxoid;Time;Tissues;Transgenic Organisms;Treatment Protocols;tumor;tumor microenvironment;uptake;Vaccinated;Vaccination;Visualization;Visualization software

PROJECT_TITLE: Monitoring Listeria in vivo using 18FDG and PET scan

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Intrusive memories of a traumatic experience are leading predictors of the onset, maintenance, and severity of transdiagnostic post-traumatic mental health difficulties; however, transdiagnostic treatments for such memories are limited as their underlying physiological mechanisms remain unclear. Tuning in to the distinct sensory-rich properties of trauma-related intrusive memories, the current project will test how the neurochemical and electrophysiological regulators of intrinsic sensory cortical activity are related to the day-to-day experiences of vivid trauma-related intrusions. Findings from this work will identify novel candidate targets for neurotherapeutics in the transdiagnostic treatment of intrusive memories in trauma-exposed individuals.

PI_NAMEs: CLANCY, KEVIN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Affective;Attention;Automobile Driving;Biological;Biological Models;career;Clinical;Clinical assessments;Cognitive;cognitive system;Conscious;Data;data integration;Development;Diagnostic;Disease;Disinhibition;Ecological momentary assessment;Electroencephalography;Electrophysiology (science);Episodic memory;Equilibrium;Event;experience;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Hippocampus;Hospitals;Impaired cognition;indexing;Individual;insight;Intervention;Investigation;Life;Link;Magnetic Resonance Spectroscopy;Maintenance;Measures;Memory;Mental Health;Mentors;Methods;model development;Modeling;multidisciplinary;multimodal data;multimodal neuroimaging;multimodality;neural;neural correlate;neural network;neural patterning;neurochemistry;neuroimaging;neurophysiology;neuroregulation;Neurotransmitters;novel;Pathology;Patient Self-Report;Pattern;phenomenological models;Physiological;Play;Positioning Attribute;Prefrontal Cortex;Process;Property;Protocols documentation;recruit;Research;Rest;Role;Sampling;Sensory;sensory cortex;sensory system;Severities;Specificity;Survivors;Symptoms;System;Techniques;Testing;Therapeutic Intervention;Therapeutic Research;Training;Training Programs;Translational Research;Trauma;trauma exposure;Visual;Visual Cortex;Work

PROJECT_TITLE: A Multilevel Characterization of Sensory Cortical Disinhibition in Post-Traumatic Intrusions

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Patients with Temporal Lobe Epilepsy and Alzheimer’s Disease suffer from debilitating impairments of learning and memory, which can have devastating consequences on everyday actions such as the ability to safely navigate back home. While considerable work has identified how neurons in the medial entorhinal cortex and hippocampus collectively form a “map” of the external environment to enable spatial learning and memory, little is known about how these maps can be flexibly used across environments with different cognitive demands. Here, we propose to use cutting-edge technology to determine how brain-wide interactions shape the flexibility of neural activity in entorhinal cortex, which in turn, will aid in elucidating potential neural mechanisms which may go awry in neurological disorders.

PI_NAMEs: CHO, FRANCES  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3-Dimensional;Accident Proneness;Alzheimer's Disease;Animals;Anterior Nuclear Group;Anterodorsal nucleus of thalamus;Back;Behavior;Behavioral;Brain;Brain region;Cells;Code;Cognitive;cognitive change;cognitive testing;cortex mapping;density;Disease;Electrophysiology (science);entorhinal cortex;Environment;Exhibits;Eye Movements;Fire - disasters;flexibility;Geometry;Goals;Head;Health;Hippocampus;Home;Impaired cognition;Impairment;improved;insight;Learning;Location;Machine Learning;machine learning algorithm;Maps;Medial;Memory;Motion;Mus;Nervous System Disorder;neural;neural circuit;neural model;neuromechanism;Neurons;optogenetics;Pathologic;Patients;Pattern;Periodicals;Physical environment;Positioning Attribute;Prefrontal Cortex;recruit;Research;Resolution;response;Reuniens Thalamic Nucleus;Rodent;Rotation;Running;Sampling;Sensory;sensory input;Shapes;Signal Transduction;Speed;Statistical Models;Structure;Techniques;Technology;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Thalamic structure;Three-dimensional analysis;Update;Video Recording;way finding;Work

PROJECT_TITLE: Convergence of top-down and bottom-up thalamic inputs in medial entorhinal cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Chronic Pain;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Ocular pain is highly prevalent, leading to decreased quality of life and suffering, and yet its pharmacologic management remains very limited. Protracted ocular pain is often associated with chronic inflammation that persists in the absence of ongoing insult. This project, grounded on our two pre-clinical models of chronic ocular pain, proposes to determine the analgesic efficacy and underlying mechanisms of topical neurokinin-1 receptor (NK1R) antagonism, as an effective non-addictive therapeutic strategy for chronic ocular pain management, utilizing its dual anti-nociceptive (anti-pain) and anti-inflammatory (thereby anti-neuropathic) properties.

PI_NAMEs: CHEN, YIHE ;DANA, REZA  (contact)

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: abuse liability;Acute;Acute Pain;addiction;Addictive Behavior;Afferent Neurons;allodynia;Analgesics;Animals;antagonist;Anti-Inflammatory Agents;antinociception;Axon;Biological Process;Calcium ion;Cells;Characteristics;Chronic;chronic neuropathic pain;chronic pain;Clinic;Clinical;clinical pain;clinical translation;Clinical Trials;conditioned place preference;Cornea;Corneal Injury;Data;Disease;efficacy evaluation;Electrophysiology (science);Esthesia;Exhibits;Exposure to;Eye;eye dryness;Eye Injuries;Eyedrops;Foundations;Genetic;Human;Hyperalgesia;Image;Immunofluorescence Immunologic;Inflammation;Label;Measurable;Mediating;Medication Management;Modeling;Molecular;mouse model;multidisciplinary;Mus;Nerve;Nerve Degeneration;nerve supply;Neurogenic Inflammation;Neuroimmune;Neurons;Neuropathy;Neuropeptides;neurosensory;Nociception;ocular pain;ocular surface;Operative Surgical Procedures;Outcome;Pain;Pain management;pain processing;pain sensation;pain signal;Parents;Pathologic;Pathway interactions;Peripheral;Peripheral Nerve Stimulation;Peripheral Nerves;Pre-Clinical Model;prevent;programs;Property;Quality of life;receptor;reflectance confocal microscopy;Refractory;Research;retinal toxicity;Rewards;sensory input;side effect;Signal Transduction;sound;Stains;Stimulus;Structure;Structure of trigeminal ganglion;Substance P;TACR1 gene;Testing;Therapeutic;therapeutic target;Time;Tissues;Toothache;Topical application;transmission process;Up-Regulation;Work

PROJECT_TITLE: Topical Neurokinin-1 Receptor Antagonist as an Effective Non-addictive Analgesic for Ocular Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (20)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunization;Immunotherapy;Vaccine Related;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE While patients with advanced or metastatic triple-negative breast cancer (TNBC) have a poor prognosis, survival can be extended, albeit, modestly using a combination of chemotherapy and immunotherapy, known as ‘chemo- immunotherapy’, reflecting the longstanding rationale that the immune system can be an integral player in the overall anti-cancer response. Here, we are testing a novel approach in preclinical models of TNBC, one based on the identification of new tumor antigens generated by the chemotherapy insult, which will then be utilized as a ‘vaccine’ to immunize the host potentially enriching the breadth of the anti-cancer immune response. Overall, immunization against these novel tumor antigens, termed ‘chemo-neoepitopes’, has the potential to enhance the efficacy of existing regimens and, thus, may have important implications for expanding treatment options for patients with advanced or metastatic TNBC receiving standard-of-care alone.

PI_NAMEs: ABRAMS, SCOTT I.;IONOV, YURIJ  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: acute infection;anti-cancer;Antigen Presentation;Antigens;antitumor effect;Antitumor Response;beta Chain Antigen T Cell Receptor;Bioinformatics;Biological Process;Blocking Antibodies;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;cancer cell;candidate identification;CD8-Positive T-Lymphocytes;Cells;checkpoint therapy;chemotherapy;Clinical;Combination Drug Therapy;complementarity-determining region 3;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Disease;DNA;DNA Damage;Drug Exposure;Epitopes;Frequencies;gamma irradiation;Gene Mutation;gene repression;Gene Silencing;Genes;Genetic Induction;Immune checkpoint inhibitor;Immune response;Immune system;Immunization;Immunize;Immuno-Chemotherapy;immunogenic;immunogenic cell death;immunogenicity;Immunotherapeutic agent;Immunotherapy;Individual;Induced Mutation;Intervention;Introns;liquid chromatography mass spectrometry;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Monoclonal Antibodies;mRNA Translation;Mus;mutant;Mutation;neoantigens;neoplastic cell;next generation sequencing;Normal Cell;novel;novel strategies;Pathway interactions;patient response;Patients;Pattern;PD-1/PD-L1;peptide vaccination;Peptides;Population;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;premature;Production;Productivity;Prognosis;protein aminoacid sequence;Proteomics;Radiation therapy;Reading Frames;Recurrence;Regimen;Reporting;Reproducibility;response;RNA;RNA Splicing;Source;Spliceosomes;standard of care;Terminator Codon;Testing;Therapeutic;TP53 gene;Transcript;transcriptome sequencing;Translations;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Vaccination;Vaccines

PROJECT_TITLE: Identifying Chemo-Neoepitopes for Immunotherapy Interventions Against Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: UPTON

ORG_NAME: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB

PHR: Project Narrative - Overall Core The Center for Biomolecular Structure (CBMS) presents state-of-the-art structural biology facilities at the National Synchrotron Light Source II (NSLS-II) to the world-wide community of researchers interested in the study of biological structure. These facilities include 1. micro-beam and highly automated macromolecular crystallography, 2. several modes of x-ray scattering from non-crystalline material, including from solutions, scattering images from tissues, and others, and 3. synchrotron x-ray footprinting of biological materials.

PI_NAMEs: MCSWEENEY, SEAN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Advisory Committees;Automation;beamline;Biocompatible Materials;bioimaging;Biological;Biological Sciences;biophysical techniques;Collimator;Communities;Complex;Computer software;Crystallography;Data;Department of Energy;Education and Outreach;Ensure;Environmental Science;experience;experimental study;frontier;Funding;Grant;Image;improved;instrument;interest;International;Investigation;Laboratories;Light;Maintenance;Measures;Methods;Modernization;multimodality;New York;operation;Pattern;peer;Peer Review;Performance;Procedures;Proteins;Research;Research Personnel;Resolution;Resources;Roentgen Rays;Science;Source;structural biology;Structure;success;Synchrotrons;Techniques;Time;Tissue imaging;tool;Training;Universities;Work;X-Ray Medical Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-L (45)]


PROJECT_TERMS: Advisory Committees;beamline;Biohazardous Substance;Biological;biological research;Biological Sciences;Businesses;Communities;Critiques;Crystallography;Data Collection;Department of Energy;Development;Education and Outreach;Ensure;Environmental Science;experimental study;Goals;Head;Health;High Pressure Liquid Chromatography;Image;Infrastructure;instrument;instrumentation;Internet;Light;Measures;meetings;Methods;Mission;Molecular;Monitor;multidisciplinary;National Institute of General Medical Sciences;operation;Performance;Positioning Attribute;Procedures;Process;Program Development;programs;Reporting;Research;Research Support;Resources;Roentgen Rays;Role;Safety;Scanning;Schedule;Science;Services;Site;Site Visit;Source;Structure;success;Synchrotrons;Techniques;Technology;time use;tomography;tool;Training;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: JAKONCIC, JEAN  (contact)

PROJECT_TERMS: Artificial Intelligence;Automation;beamline;Biological;Collaborations;Communities;Companions;Computer software;computerized data processing;Computers and Advanced Instrumentation;computing resources;Confusion;Crystallography;Data Analyses;Data Collection;data quality;data reduction;data structure;density;Department of Energy;detector;Development;drug development;Ensure;experimental study;Feedback;flexibility;frontier;Funding;Grant;High Performance Computing;Hybrids;improved;International;large language model;Light;Machine Learning;Maintenance;Methods;new technology;operation;Optics;Performance;Photons;Preventive;Process;Property;quality assurance;Research;Research Support;Research Training;Resource Development;Resources;Robot;Roentgen Rays;Sampling;Scanning;Science;scientific computing;screening;Secure;Software Tools;Source;Speed;Structural Biologist;structural biology;Structural Models;Structure;Synchrotrons;Techniques;Technology;Temperature;Time;tool;Training;United States;United States National Institutes of Health;Update

PROJECT_TITLE: Macromolecular Crystallography Core


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: YANG, LIN  (contact)

PROJECT_TERMS: Adopted;Area;Automation;Basic Science;beamline;Biological;Biological Sciences;cell fixing;Cells;Center Core Grants;Charge;Communities;Computer software;computerized data processing;computing resources;COVID-19 pandemic;Data;Data Analyses;Data Collection;data quality;data visualization;Department of Energy;design;detector;Devices;Elements;Ensure;Environment;experience;flexibility;Fluorescence;fly;Funding;Grant;High Pressure Liquid Chromatography;Image;improved;Individual;instrument;instrumentation;Investigation;Laboratories;Light;Liquid Chromatography;macromolecule;Maintenance;Maps;Measurement;National Institute of General Medical Sciences;Neutrons;new technology;operation;Optics;Performance;Photons;programs;Pythons;Research;research and development;Research Personnel;Research Support;Resources;Robot;Roentgen Rays;Sampling;Scanning;software development;Software Tools;Source;Structure;Synchrotrons;System;Techniques;Technology;Thinness;Time;Tissues;tomography;tool;Training;training opportunity;United States National Institutes of Health;usability;Vacuum;Work

PROJECT_TITLE: X-ray Scattering Technology Core


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: FUCHS, MARTIN  (contact)

PROJECT_TERMS: Adopted;Award;beamline;bioimaging;Biological;Biological Sciences;Collaborations;Communication;Communities;computational platform;Computer software;Computer Systems;computerized data processing;computing resources;cost effective;Crystallography;Data Analyses;data management;Dedications;density;Department of Energy;design;Discipline;Engineering;Ensure;Equipment Failure;experimental study;flexibility;Fostering;frontier;Funding;Goals;Grant;Home;Human Resources;Image;imaging facilities;improved;Infrastructure;Institution;instrument;instrumentation;International;Investments;Knowledge;Laboratories;Light;Maintenance;meetings;Methods;models and simulation;multimodality;operation;Performance;programs;repaired;Research;Resolution;Resource Sharing;Resources;Rest;Roentgen Rays;Role;Science;Site;software development;Source;Standardization;structural biology;Structure;Support Groups;Synchrotrons;System;Techniques;Technology;tool;United States National Institutes of Health;Universities;Work;X ray diffraction analysis

PROJECT_TITLE: Integrated Technologies Core


PI_NAMEs: STOJANOFF, VIVIAN  (contact)

PROJECT_TERMS: Address;Awareness;beamline;Clip;Collaborations;Communication;Communities;Computer software;COVID-19 pandemic effects;Development;Education and Outreach;Educational workshop;experience;General Population;Goals;graduate student;Grant;Historically Black Colleges and Universities;Hour;Image;improved;interest;Knowledge;Learning;Manuals;member;Methodology;Methods;Microscopy;Minority-Serving Institution;multidisciplinary;multimodality;outreach;outreach program;Persons;Preparation;programs;Publications;recruit;Research;research facility;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Sampling;Schedule;Schools;Services;skills;Structure;success;symposium;Techniques;Time;Training;training project;user-friendly;web page

PROJECT_TITLE: User Training and Research Project for CBMS


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE – Per Parent Award R01CA259046 Non-genetic changes in gene expression promote melanoma progression and metastasis; however, whether aberrant miRNA sequestration by competitive endogenous RNAs (ceRNAs) is involved in this process is unknown. We have discovered a cluster of ceRNA genes located on the frequently gained chromosome 1q region, and found that the mRNA with the greatest predicted ceRNA potential, CEP170, promotes melanoma migration/invasion in vitro and metastasis in vivo. We propose to define the miRNA-dependent oncogenic potential of CEP170 and characterize how the deregulation of downstream miRNAs and ceRNA effectors provokes melanoma metastasis.

PI_NAMEs: KARRETH, FLORIAN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Binding;Binding Sites;Biological;Biology;Cause of Death;cell motility;Cellular biology;chromosome 1q gain;Chromosome Mapping;Chromosomes;Clinical;Code;Cultured Cells;Development;Disease;Drops;Epigenetic Process;Excision;Exhibits;experimental study;Future;Gene Expression;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genomic Segment;Genomics;Goals;Human;In Vitro;in vivo;Incidence;Invaded;Laboratories;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;melanomagenesis;Messenger RNA;Metastatic Melanoma;metastatic process;MicroRNAs;migration;Modeling;Molecular;Molecular Biology;mouse model;mutant;Mutation;Neoplasm Metastasis;non-genetic;novel;Oncogene Deregulation;Oncogenic;Outcome;overexpression;parent project;Persons;Phenotype;Porifera;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Proteins;Regulation;Repression;Research;Resources;RNA;RNA I;Role;Series;Survival Rate;Testing;tool;Transcript;tumor;Untranslated RNA;Work

PROJECT_TITLE: Chromosome 1q ceRNAs in Melanoma Progression and Metastasis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to these disparities, and the increased burden of gender minority stress may also be driving higher prevalence rates of anxiety and depression, both of which are more common among TGD individuals and among those who smoke relative to comparison samples. This study will (1) explore the ways in which gender minority stressors and associated anxiety and depression compromise smoking cessation among TGD individuals, identifying elements in an existing smoking cessation intervention that need to be adjusted to meet their unique needs; (2) adapt an existing smoking cessation intervention for TGD individuals; and (3) evaluate the feasibility and acceptability of the adapted intervention in a pilot randomized controlled trial.

PI_NAMEs: O'CLEIRIGH, CONALL MICHAEL (contact);STANTON, AMELIA M.

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;Adult;American;Anxiety;anxiety symptoms;associated symptom;Attention;Automobile Driving;Behavioral;behavioral health;Cause of Death;cigarette smoke;cigarette smoking;cis-male;cisgender;Clinical;Cognitive;Cognitive Therapy;Communities;coping mechanism;craving;Data;Depressed mood;depressive symptoms;Discrimination;Disparity;distress tolerance;effectiveness trial;electronic cigarette use;Elements;Employment;expectation;experience;Exposure to;feasibility testing;Focus Groups;follow-up;Gender Confirmation Surgery;gender diverse;gender dysphoria;Gender Identity;gender minority;gender minority stress;General Population;Goals;harassment;Health;health care settings;Health Personnel;heart disease risk;High Prevalence;HIV;hormone therapy;Housing;Hybrids;Impairment;implementation barriers;implementation intervention;improved;Individual;internalized stigma;Intervention;Lesbian Gay Bisexual Transgender;Link;long term abstinence;Major Depressive Disorder;Mediating;Mental Depression;Mental Health;minority stress;minority stressor;Modeling;negative affect;Neighborhood Health Center;Outcome;Participant;Patients;Persons;Population;Prevalence;Primary Health Care;primary health center;primary outcome;Process;promote resilience;protective factors;Provider;Published Comment;Randomized, Controlled Trials;Recovery;recruit;Reporting;Research;resilience factor;response;Sampling;secondary outcome;Sex Orientation;sexual minority group;Signal Transduction;skills;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;smoking relapse;smoking-related disease;social stigma;standard of care;stress symptom;substance use;success;suicidal;Surveys;Testing;Tobacco use;transgender;transgender men;transgender women;United States;vaping;verbal;Withdrawal Symptom;Work

PROJECT_TITLE: Adapting and testing a smoking cessation intervention for transgender and gender-diverse individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Thyroid cancer affects up to 1-in-10 people in the United States, and there are several acceptable treatments. While prognosis is excellent, these treatments are costly to society and may produce significant adverse effects. This study uses a preference-elicitation instrument to measure how patients value different treatments for small, low-risk thyroid cancers so that we can maximize value-for-cost through consensus guidelines and policy.

PI_NAMEs: HU, YININ  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;Address;Adult;Adverse effects;Affect;Aftercare;Baltimore;Benign;Biometry;Cancer Survivor;Carcinoma;career development;Caring;Cessation of life;Clinical;Clinical Research;cognitive load;cohort;comparative cost effectiveness;Consensus;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Cross-Sectional Studies;Data;design;Disease;Doctor of Philosophy;Education;Educational Status;epidemiology study;experience;Familiarity;Fellowship;follow-up;General Population;Guidelines;Health;health economics;Health Personnel;Health Policy;Health Services Research;Health Technology;Hormones;Hypocalcemia;improved;instrument;K-Series Research Career Programs;Knowledge;Malignant neoplasm of thyroid;Maryland;Master of Science;mathematical model;Measures;medical schools;Mentors;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;Operative Surgical Procedures;Papillary;Paresis;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Perception;Persons;Pharmacy Schools;Physicians;Pilot Projects;Policies;Positioning Attribute;preference;Process;professor;Prognosis;Publishing;Radiofrequency Interstitial Ablation;Research;Resource Allocation;Resources;Respondent;Risk;Series;societal costs;Societies;Specialist;Supplementation;Surgical Oncology;Surveys;Survivors;Technology Assessment;Testing;Thyroid Diseases;Thyroid Gland;Thyroidectomy;Time;time use;Training;Treatment Cost;treatment strategy;United States;Universities;vocal cord;volunteer

PROJECT_TITLE: Preference-Based Treatment Valuation in Low-Risk Thyroid Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Existing and proposed mental health quality measures may be biased against health systems, facilities, and clinicians serving more Black and Hispanic patients, measuring the patients they serve rather than the quality of care they provide. This research will use detailed records data from five large health systems to evaluate potential biases in existing and proposed measures and evaluate alternatives to reduce biases.

PI_NAMEs: SIMON, GREGORY E. (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Accounting;Address;Affect;Anxiety;anxiety treatment;Black race;care episode;care providers;Caring;Characteristics;Clinical;Collaborations;Community Practice;Complex;Data;design;Disadvantaged;Disease remission;disparity reduction;Effectiveness;ethnic difference;ethnic disparity;Evaluation;Family member;Fee-for-Service Plans;Health Care Quality Assurance;Health system;Healthcare;Healthcare Systems;Hispanic;improved;improved outcome;Incentives;Individual;Inequity;interest;Measurement;Measures;Medicare;Mental Depression;Mental Health;Methods;National Committee for Quality Assurance;Neighborhoods;Outcome;Outcome Assessment;Pathway interactions;patient population;Patients;payment;Population;Population Heterogeneity;preference;Prognosis;programs;Quality Indicator;Quality of Care;Race;racial difference;racial disparity;Recording of previous events;Records;Reporting;Research;response;Rewards;Severities;social;social determinants;social health determinants;Specific qualifier value;Standardization;Structure;System;Treatment Failure;United States Centers for Medicare and Medicaid Services;Work

PROJECT_TITLE: Identifying and addressing bias in depression and anxiety quality measures

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (05)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative Dysregulated proteostasis, particularly protein turnover, is a hallmark of brain aging and Alzheimer’s Disease (AD), but many details remain to be understood about protein turnover due to previous technical limitations. In this proposal, leveraging new protein-tagging methodologies, l aim to (1) identify aberrations in neuronal protein turnover dynamics and their functional consequences during aging and AD and (2) understand a neuron-intrinsic regulator of protein turnover (autophagy/lysosome) and a neuron-extrinsic regulator of neuronal protein turnover (microglia) during aging and AD. The findings from my studies will substantially increase our basic biological understanding of neuronal proteostasis/protein turnover during brain aging and AD, and ultimately identify new targets to promote resilience to brain aging and AD.

PI_NAMEs: GULDNER, IAN HUNTER (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Affect;Age;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amino Acids;Amino Acyl-tRNA Synthetases;Amyloid beta-Protein;Autophagocytosis;Award;Azides;Biological;Biological Models;Biology;Brain;brain health;cell type;Cells;Clinical;Collaborations;Communication;Data Set;Development;Disease Pathway;disease phenotype;Educational workshop;empowerment;Etiology;experimental study;follow-up;Functional disorder;Health;Homeostasis;Human;Immunoprecipitation;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;innovation;insight;Kinetics;Knock-out;Label;Learning;liquid chromatography mass spectrometry;loss of function mutation;lysosomal proteins;Lysosomes;Maintenance;Mass Spectrum Analysis;Mediating;Mediator;Mentors;Methodology;Methods;Microglia;Modeling;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;New Territories;novel;old mice;overexpression;Pathologic;Pathology;Pathway interactions;Phenylalanine;Physiologic pulse;Positioning Attribute;prevent;Process;promote resilience;Protein Biosynthesis;protein degradation;Proteins;Proteome;proteostasis;proteostasis loss;Rationalization;Regulation;Research;Research Personnel;resilience;resilience in aging;Resistance;Risk Factors;Role;Scheme;therapeutic target;Time;Tissues;tool;Training;Transgenic Mice;TREM2 gene;uptake

PROJECT_TITLE: Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging Tools

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE One in five American children live in rural regions, and almost 3 million of these have chronic health conditions. The overall objective of this project is to analyze three States’ all-payer claims data to comprehensively evaluate urban-rural disparities in healthcare utilization and quality for children with complex or disabling health conditions, and to identify community and health system factors associated with these disparities. This research will be the first population-level analysis to characterize the magnitude of urban-rural disparities in healthcare quality for children with chronic and disabling conditions, generating foundational knowledge to improve clinical care and public health support for this vulnerable population.

PI_NAMEs: LEYENAAR, JOANNA  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Adult;adverse outcome;Ambulatory Care;American;Area;Attenuated;beneficiary;care outcomes;care systems;Caring;Characteristics;Child;Child Care;Child health care;Childhood;Chronic;Chronic Disease;Clinical;clinical care;Colorado;Communities;Complex;complex chronic conditions;cost;Data;disability;Disabling condition;Disease Management;Disparity;effective intervention;Emergency department visit;Emergency Situation;Ethnic Origin;Ethnic Population;Evaluation;experience;Future;Geography;Health;health care availability;health care disparity;health care quality;health care service utilization;health disparity;Health Personnel;Health system;Healthcare;Healthcare Systems;High Prevalence;high risk;Hospital Charges;hospital readmission;Hospitalization;improved;improved outcome;Inpatients;Insurance;Intervention;Knowledge;Length of Stay;Massachusetts;Measures;Medical;medical specialties;Medicare;multidisciplinary;New Hampshire;novel;organizational structure;Outcome;Pathway Analysis;Patients;Patterns of Care;Pediatric Hospitals;peer;Physicians;Population;Population Heterogeneity;Poverty;Preventive care;Preventive healthcare;primary care provider;Provider;Public Health;Quality of Care;Race;racial population;readmission risk;Reduce health disparities;Reporting;Research;Resources;Retrospective cohort study;Risk;Rural;rural area;rural disparities;rural health disparities;rural residence;rural setting;rurality;Services;Social Network;Specialist;Surveys;tertiary care;Time;Travel;Underserved Population;United States;urban area;urban setting;Vulnerable Populations;Work

PROJECT_TITLE: Urban-Rural Disparities in Healthcare Quality for Children with Complex or Disabling Health Conditions

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Structural variants (SVs) are frequently associated with disease phenotypes and represent the largest and most complex source of human genomic variation. Limitations in sequencing technologies lead to challenges in the accurate discovery and characterization of SVs, but which can be overcome by taking an integrative approach leveraging the advantages of multiple platforms, as well as by utilizing more comprehensive reference genome representations such as the pangenome graph. In this proposal, I will be constructing an SV calling pipeline which is versatile to technological developments across sequencing platforms, and which can leverage the latest developments in graph genome reference representations to achieve high-performance results.

PI_NAMEs: PERDOMO, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Area;Awareness;base;Base Pairing;Bioinformatics;Biomedical Engineering;Biomedical Research;candidate identification;career;Collection;Communication;Communities;Complex;computerized tools;contig;Data;data integration;Data Science;Detection;Development;Disease;disease phenotype;doctoral student;Education;Ethnic Population;file format;Future;Genetic Variation;Genome;genome sequencing;genome-wide;Genomic DNA;genomic platform;genomic variation;Genomics;Goals;Graph;Haplotypes;Human;Human Genome;human pangenome;human reference genome;insertion/deletion mutation;Lead;Length;machine learning model;Maps;Methods;Modeling;novel;Optics;Oral;pan-genome;Performance;Population;reference genome;Repetitive Sequence;Research Training;Resolution;Resources;restriction enzyme;scaffold;Sequence Alignment;sequencing platform;Site;skills;Source;statistics;Structure;Technology;technology development;Time;tool;Variant;variant detection;whole genome;Work;Writing

PROJECT_TITLE: Novel bioinformatics methods for integrative detection of structural variants from long-read sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Women with atrial fibrillation (AF), a common cardiac arrhythmia, endure higher symptom burden and lower quality of life (QOL) compared to men, but the factors that contribute to these gender differences remain largely unknown. The proposed research will elucidate and compare differences in social (social support, living situation, social network interaction) and biological (epicardial adipose tissue and adipokines) factors that influence AF symptoms and QOL in women and men. Findings generated from this investigation will provide foundational knowledge for a program of research focused on interventions that bridge the gender gap and improve symptom burden and QOL in AF.

PI_NAMEs: FRAZIER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Ablation;Address;adipokines;adiponectin;Adipose tissue;Age;Anti-Inflammatory Agents;Anticoagulation;Arrhythmia;Atrial Fibrillation;Award;Behavior Therapy;biobehavior;Biological;Biological Factors;Biological Markers;Biology;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;Caring;Cicatrix;comorbidity;Complex;Cross-Sectional Studies;cytokine;debilitating symptom;Dedications;design;Diabetes Mellitus;Diagnosis;Disease;doctoral student;Evaluation;experience;Fatigue;Fellowship;Foundations;Future;Gender;gender difference;General Population;Goals;Health;health determinants;Health Promotion;Heart;Heart Atrium;Heart failure;Heart Rate;heart rhythm;Hypertension;imaging modality;Impairment;Incidence;Individual;Individual National Research Service Award;Inflammation;inflammatory marker;innovation;Intervention;Interview;Investigation;Knowledge;Left;lens;Leptin;Life Style Modification;Link;Literature;Medical center;men;Metabolic;Methods;mortality risk;Myocardium;novel;Nurses;Nursing Research;Obesity;Outcome;Palpitations;Participant;Pathway interactions;Patients;Personal Satisfaction;Persons;Population;pre-doctoral;Prevention;Procedures;programs;Qualitative Methods;Quality of life;reduce symptoms;Reporting;Research;Research Training;response;Risk;Risk Factors;Role;Sampling;School Nursing;Scientist;Shortness of Breath;Signal Transduction;Sinus;social;Social Environment;social factors;Social Network;Social Perception;Social support;stroke risk;Structure;study population;Symptom Burden;symptomatic improvement;Symptoms;Tissues;Training;Universities;Visceral fat;Washington;Woman;women versus men

PROJECT_TITLE: Differences in Women and Men with Atrial Fibrillation

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(87)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Suicide

ORG_CITY: NOTRE DAME

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE  Stressful events are a well-established risk factor for suicidal ideation, but a more granular understanding of when stressful events increase risk for suicidal ideation, as well as which person-level markers exacerbate this risk relationship, is imperative. This research will: (1) evaluate the direct effect of real-time stressful events on concurrent and prospective momentary suicidal ideation, (2) evaluate the moderating effects of trait and state impulsivity and emotion dysregulation on the stressful events – momentary suicidal ideation relationship, and (3) explore the propensity to experience suicidal ideation in response to prior stress as a potential moderator of this association. Findings of the proposed research will specify person-level conditions that portend imminent suicidal ideation, information that has the potential to inform the development of effective just-in-time interventions, consistent with precision care objectives of the NIMH Strategic Plan.

PI_NAMEs: KNORR, ANNE  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Accidents;Accounting;acute stress;Adult;Age;Aging;Cessation of life;Cognitive;Development;Discrimination;Ecological momentary assessment;emotion dysregulation;Emotional;Environment;Ethics;Etiology;Event;experience;Feeling suicidal;Fellowship;Frequencies;Future;Goals;high risk;high risk population;improved;Impulsivity;Individual;Individual Differences;Intervention;Investments;Joints;Knowledge;longitudinal design;Maps;Measures;men;mortality;National Institute of Mental Health;next generation;Pathway interactions;Personality;personalized care;Persons;Phase;Predisposition;prevent;Prevention;prospective;Reaction;recruit;Reporting;Research;response;Risk;Risk Factors;Risk Reduction;Sampling;skills;Specific qualifier value;Statistical Data Interpretation;Strategic Planning;Stress;Stressful Event;suicidal behavior;suicidal risk;Suicide;suicide rate;Testing;Time;Training;trait;United States;Universities

PROJECT_TITLE: Stress experiences as markers of person-level vulnerability and temporal risk for near-term suicidal ideation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-H(20)L]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: CHICAGO

ORG_NAME: MICROSENSOR LABS, LLC

PHR: Project Narrative This SBIR project aims to continue developing and validating a novel magnetic cytometer to rapidly isolate, identify and sort single intact and viable cells from heterogeneous cell population. The project will provide a powerful tool for single cell analysis and have a broad impact in both basic research and clinical applications.

PI_NAMEs: LIU, PENG PAUL  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: antigen-specific T cells;B-Lymphocytes;Basic Science;Biological Sciences;Cell Culture Techniques;cell fixation;Cell Line;Cell Separation;Cell Survival;Cells;Clinical;clinical application;Computer software;Consumption;Development;fetus cell;Magnetism;Micromanipulation;Molecular Analysis;monoclonal antibody production;Neoplasm Circulating Cells;next generation;novel;Phase;Population;precision medicine;rapid growth;Research Project Grants;Resolution;Sampling;Semiconductors;single cell analysis;Small Business Innovation Research Grant;Sorting;Stains;stem cells;System;Techniques;Technology;Time;tool

PROJECT_TITLE: SBIR Fast Track: Development of a High-throughput Magnetic Cytometer for Single Cell Sorting


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The study goal is to promote viral load suppression among women with serious mental illness (SMI) and HIV in Botswana, given that these women are especially vulnerable to psychiatric medication nonadherence and symptom exacerbation, which are made worse by stigma and threaten antiretroviral therapy (ART) adherence. We propose to test an intervention to reduce stigma due to the statuses of SMI and HIV, against an attention control condition, in the high-risk transition period after discharge from an initial psychiatric hospitalization. Enabling women with SMI and HIV to resist stigma has the potential to improve their HIV outcomes and empower these women to elicit broader, structural-level change.

PI_NAMEs: YANG, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 2 arm randomized control trial;Acute;Address;Adherence;Africa South of the Sahara;Ambulatory Care;antiretroviral therapy;arm;Articulation;Attention;attentional control;Binding;Botswana;Caring;Client;Communities;community reintegration;compare effectiveness;coping;Depressive disorder;depressive symptoms;Educational workshop;empowerment;Ensure;Face;Family;Family Caregiver;Family member;follow-up;Foundations;Funding;Future;Goals;Health system;high risk;HIV;Household;improved;inpatient psychiatric treatment;Inpatients;Intervention;intervention effect;Lived experience;marginalization;marginalized population;Measures;medication nonadherence;Mental Health;Modeling;Mothers;novel;Outcome;peer;Perception;personalized approach;Personhood;Persons;Pharmaceutical Preparations;Placebo Control;Policies;Policy Maker;post intervention;Postpartum Period;Pregnant Women;Prevalence;primary outcome;Professional counselor;Public Health;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Respondent;Risk;scale up;Schizophrenia;secondary outcome;Services;severe mental illness;Social outcome;social stigma;Symptoms;Testing;therapy adherence;therapy design;treatment adherence;Viral;Viral Load result;Woman;Women Status;women's outcomes

PROJECT_TITLE: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: GAITHERSBURG

ORG_NAME: INSTITUTE FOR IN VITRO SCIENCES, INC.

PHR: Project Narrative The Institute for In Vitro Sciences is organizing and hosting a series of expert Workshops (8 so far) to identify, discuss and publish recommendations for the best scientific/technical approaches to the generation and interpretation of in vitro assay (initially genetic toxicity) data that can be used to compare toxicity across different tobacco products, and within and between classes of tobacco products. These recommendations will assist public health researchers in performing high quality experiments to understand the relative toxicities of conventional cigarettes, the new Electronic Nicotine Delivery Systems (ENDS), and other tobacco-related products. Such studies will then provide public health officials with the high quality data they need to make science-based decisions during the regulation of tobacco and nicotine containing products.

PI_NAMEs: CURREN, RODGER D (contact)

PROGRAM_OFFICER_NAME: STATON, JILL

PROJECT_TITLE: Workshop series to identify, discuss and develop recommendations for the optimal generation and use of in vitro assay data for tobacco product regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CTP-J (01)]


NIH_SPENDING_CATS: Aging;Back Pain;Behavioral and Social Science;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Pain Research

ORG_CITY: AKURE

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: THE FEDERAL UNIVERSITY OF TECHNOLOGY, AKURE, NIGERIA

PHR: PROJECT NARRATIVE Intervertebral disc degeneration (IVDD) is a multifactorial process regarded as the primary cause of low back pain that exerts an enormous public health burden and disability on millions of individuals with current conserva- tive surgical options having limited treatment efficacy. This study evaluates the modulating role of gene therapy, an unleveraged therapeutic intervention, on pyroptosis-mediated pathways in a rat model of IVDD progression over 12 weeks. Uncovering the potential of gene therapy as an alternative treatment option for low back pain and its role in pyroptosis proteins aligns with the National Institute of Health’s mission and Fogarty International Center’s vision statements to reduce disease burden and disability, improve health, and extend longevity for all people. 1

PI_NAMEs: OGUNLADE, BABATUNDE  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adult;Affect;Africa South of the Sahara;African;Aging;Alternative Therapies;alternative treatment;Apoptosis;Award;Behavior;Biomedical Research;biomedical scientist;burden of illness;Caring;CASP1 gene;CASP3 gene;Caspase;Cell Death;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Chronic low back pain;comparison control;Control Groups;cytokine;Data;Data Analyses;data management;Degenerative polyarthritis;Deposition;design;Deterioration;Development;disability;Discipline;Disease;Disease Progression;Economic Burden;effective intervention;Effectiveness;Experimental Animal Model;Extracellular Matrix;Fogarty International Center;gene therapy;global health;Goals;Health;Healthcare;Height;High Prevalence;Homeostasis;Human;IL18 gene;Immunofluorescence Immunologic;Immunohistochemistry;improved;Individual;Inflammatory;innovation;insight;Interleukin-1;Interleukin-1 beta;Intervention;Intervention Studies;intervertebral disk degeneration;Knowledge;Knowledge acquisition;Learning;Longevity;loss of function;low and middle-income countries;Low Back Pain;Low Prevalence;Manuscripts;Mediating;Mediator;Medical;Mentors;Mentorship;Methods;MicroRNAs;Mission;Modeling;Musculoskeletal Diseases;National Institute on Aging;Needles;next generation;Nigeria;Nigerian;novel;nucleus pulposus;Occupational;Operative Surgical Procedures;Organ;Pain;Pathology;Pathway interactions;Personal Satisfaction;Persons;Polymerase Chain Reaction;preclinical study;preservation;Prevalence;Process;Productivity;Proteins;Public Health;Puncture procedure;Radiology Specialty;Rattus;receptor;reduce symptoms;Regulation;repaired;Research;Research Design;Research Methodology;Resources;Role;Route;Safety;Scientist;Shock;social;socioeconomics;Spinal;Structure;support network;Support System;Therapeutic Intervention;Time;Tissues;TNF gene;Training;Translational Research;Treatment Cost;Treatment Efficacy;United States National Institutes of Health;Vertebral column;Vision;Western Blotting;Work;Writing

PROJECT_TITLE: Unravelling the role of gene therapy on spinal disc mediated low back pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Precision Medicine;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Acquired therapy resistance is a major problem for patients with metastatic prostate cancer. This proposal seeks to identify novel strategies to prevent acquired therapy resistance by studying a rare subtype of prostate cancer with IDH1 mutation that fails to acquire therapy resistance.

PI_NAMEs: SENA, LAURA A. (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: alpha ketoglutarate;Androgen Receptor;Biological;Biological Sciences;cancer cell;cancer subtypes;candidate identification;Castration;chemotherapy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Cre driver;Cues;Data;demethylation;Development;Dioxygenases;Disease;DNA;DNA Methylation;Epigenetic Process;epigenetic regulation;Epithelium;exome sequencing;Gene Expression;gene therapy;Genetic Transcription;Genomics;Glioma;Goals;Hematologic Neoplasms;histone methylation;Hypermethylation;In Vitro;in vivo;Incidence;individualized medicine;inhibitor;insight;Isocitrate Dehydrogenase;Isocitrates;Knock-in;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Metastatic Prostate Cancer;Molecular;molecular subtypes;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;novel strategies;Outcome;Pathway interactions;Patients;Persons;Point Mutation;prevent;Primary Neoplasm;programs;Progression-Free Survivals;Prostate;Receptor Inhibition;Receptor Signaling;Relapse;Research;Resistance;response;Solid Neoplasm;Stress;stressor;Systemic Therapy;Testing;therapeutic candidate;therapeutic target;therapy duration;therapy resistant;Time;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;treatment response;tumor;tumorigenesis

PROJECT_TITLE: A study of IDH1-mutant prostate cancer to identify novel therapeutic targets

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M3)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Rural areas experience several vaccine-related disparities, yet little is known about two salient public health issues (COVID-19 vaccination and general vaccine hesitancy) in such areas. The proposed study will analyze existing data on a national sample of participants to provide an in-depth understanding of how rurality affects COVID-19 vaccine coverage and general vaccine hesitancy. Findings will lay the foundation for future interventions to increase COVID-19 vaccine coverage and decrease general vaccine hesitancy in rural areas.

PI_NAMEs: REITER, PAUL L (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TITLE: COVID-19 Vaccine Coverage and General Vaccine Hesitancy in Rural Areas in the United States

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Patient Safety;Prevention;Primary Health Care;Suicide;Suicide Prevention;Violence Research

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHIATRY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Suicide is a major public health concern in the United States, and healthcare systems have begun implementing evidence-based screening, prevention, and intervention approaches to mitigate risk. New national process and outcome quality measures are needed to assess whether suicide prevention processes are being implemented and whether suicide outcomes are improved. This proposed R01 application develops and tests quality measures for suicide prevention across multiple health systems in partnership with leading quality organizations.

PI_NAMEs: AHMEDANI, BRIAN KENNETH (contact);PENFOLD, ROBERT B.

PROJECT_TERMS: 10 year old;Accreditation;Acute;Adoption;Age Years;behavioral health;Benchmarking;Caring;Cessation of life;Clinical;Code;Collaborations;Colorado;Consensus;Country;Data;Death Rate;Death Records;design;Development;Diagnosis;Electronic Health Record;Emergency Situation;evidence base;Feeling suicidal;follow-up;Funding;Geography;Goals;Health;Health Insurance;Health Services;Health system;Healthcare;Healthcare Systems;implementation efforts;implementation study;improved;improved outcome;Inpatients;insurance claims;International;Intervention;Joints;Location;machine learning model;Measurement;Measures;medical specialties;meetings;member;Mental Health;Michigan;Movement;National Committee for Quality Assurance;National Institute of Mental Health;Network Infrastructure;Outcome;Outcome Assessment;Outcome Measure;Outpatients;Pathway interactions;Patients;Performance;Population;Prevention;Prevention approach;prevention service;Primary Care;Procedures;Process;Process Measure;Professional Organizations;Public Health;Quality of Care;Questionnaires;Recommendation;reducing suicide;Reporting;Research;Research Personnel;Research Priority;Resources;Risk;Risk Assessment;risk mitigation;Safety;screening;Screening procedure;Series;Services;Severities;Shapes;Site;standard of care;Standardization;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;System;Testing;Text;tool;treatment services;United States;Visit;Washington;Work

PROJECT_TITLE: Quality Measures to Advance Suicide Prevention and Care Across Health Systems


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

PHR: Project Narrative There is a growing mental health crisis among older adults, which may be exacerbated by limited access to mental health specialists in the rapidly growing Medicare Advantage program. This project will characterize geographic access to mental health specialists for older adults and evaluate how access to specialists impacts mental health treatment and outcomes for older adults in the Medicare Advantage program. This application will support a new investigator who aspires to a research career focused on improving access to mental and behavioral health treatment in underserved populations and will allow him to develop new skills necessary to achieving this goal.

PI_NAMEs: MEISELBACH, MARK  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Affect;age group;age related;aged;Aging;Alzheimer's disease related dementia;Anxiety Disorders;Appointment;Area;associated symptom;behavioral health;beneficiary;career;career development;Caring;Catchment Area;Clinical;clinical practice;Data;Data Linkages;Data Sources;Databases;Dementia;Demographic Factors;Depressive disorder;Development Plans;Diabetes Mellitus;Diagnosis;Directories;econometrics;Economic Factors;Economics;effective therapy;Effectiveness;Emergency department visit;Enrollment;Evaluation;experience;Fee-for-Service Plans;Feeling suicidal;Foundations;Geographic Factor;Geographic Locations;Geography;geriatric mental health;Geriatric Psychiatry;Geriatrics;Goals;Growth;Health;Health Policy;Health Services;Health Services Research;Hospitalization;human old age (65+);Improve Access;improved;improved outcome;Income;instrument;Insurance;Insurance Carriers;Intervention;K-Series Research Career Programs;Leadership;Link;Measurement;Measures;medical specialties;Medicare;Medicare claim;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Modeling;National Institute of Mental Health;novel;older adult;Outcome;Patients;Pharmaceutical Preparations;Play;Policies;Prevalence;Prevention;Privatization;programs;Provider;provider factors;provider networks;Psychiatrist;Psychotherapy;Public Health;rapid growth;Regulation;Reporting;Research;Research Personnel;Risk Factors;Role;Services;severe mental illness;side effect;skills;social stigma;Specialist;statistics;suicide rate;Techniques;Time;Training;Translating;Travel;treatment and outcome;Underserved Population;Variant;Vascular Diseases;Visit;Work

PROJECT_TITLE: Access to Mental Health Care Specialists in Medicare Advantage: Improving Outcomes for Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-I (01)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Soil-transmitted parasitic nematodes infect over a billion people around the world and can cause devastating and sometimes fatal illness, but their basic biology remains almost entirely unexplored. The proposed research will investigate how temperature cues shape the specialized behavioral and physiological responses of parasitic nematodes. Our results will elucidate the key molecular and cellular mechanisms that underlie the remarkable thermal adaptability of mammalian parasitic nematodes, establishing an essential foundation to enable the development of novel interventional strategies.

PI_NAMEs: BRYANT, ASTRA SHAMGAR (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adult;Antiparasitic Agents;Automobile Driving;Award;Behavior;Behavioral;Behavioral Assay;behavioral response;Biology;Caenorhabditis elegans;Candidate Disease Gene;comparative;comparative genomics;Complex;CRISPR/Cas technology;Cues;Cyclic GMP;design;Development;Ectopic Expression;Environment;Evolution;Exhibits;experimental study;Foundations;functional genomics;gastrointestinal;Genetic;Genome;Genomics;global health;Goals;Health;Helminths;Hookworms;Human;Human Biology;Infection;insight;Intervention;Invaded;knockout gene;Knowledge;Larva;Life;Life Cycle Stages;Link;Mammals;Maps;Modeling;Molecular;Molecular Biology;Mutagenesis;neighborhood disadvantage;Nematoda;Nervous System;neural;neural circuit;neuroadaptation;neuroimaging;Neurons;Neurosciences;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Parasites;Parasitic nematode;parasitism;Parasitology;Pathway interactions;Penetration;Persons;Phase;Phylogenetic Analysis;Physiological;Physiology;preference;Process;programs;Reproduction;Research;Resolution;response;Role;Schistosoma;Sensory;Shapes;Signal Transduction;Skin;socioeconomic disadvantage;Soil;Strongyloides;Strongyloides stercoralis;System;targeted treatment;Temperature;Therapeutic Intervention;tool;transmission process;TRP channel;virtual;Work

PROJECT_TITLE: Dissecting the thermosensory biology of soil-transmitted parasitic nematodes

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This project aims to address the pervasiveness of structural racism and discrimination (SRD) and its impact on the health of rural Black adolescents. Integrating Life Course Theory with community-based systems dynamics, our study will investigate potential intervention strategies aimed at reducing adolescent exposure to SRD and mitigating the impact of SRD within neighborhoods, schools, and peer networks on adolescent substance use and mental health. Study findings will yield data-driven recommendations for policy and community-level interventions; offering insights into key implementation factors while advancing efforts to reduce adolescent health inequities.

PI_NAMEs: TAGGART, TAMARA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Administrator;Adolescent;Adolescent Development;adolescent health;adolescent substance use;Adverse effects;Affect;American;Biological Models;Black race;built environment;candidate identification;candidate selection;Censuses;Characteristics;Child;Civil Rights;Collection;Communities;community based participatory research;community engaged approach;community intervention;community setting;Community Surveys;Complex;County;Data;Data Sources;Discipline;Discrimination;dynamic system;Educational workshop;Eligibility Determination;ethnic minority;experience;Exposure to;Face;Focus Groups;geographic disparity;Goals;Health;health determinants;health equity;health inequalities;Health Policy;implementation determinants;improved;Individual;insight;Intervention;intervention mapping;Interview;Investments;Life;Life Cycle Stages;Link;Longitudinal cohort;Maps;Measures;Mental Depression;Mental Health;model building;Modeling;Neighborhoods;North Carolina;Outcome;Parameter Estimation;Participant;peer networks;Policies;Policy Maker;policy recommendation;Population;population health;Property;public health intervention;Race;racial diversity;racial minority;Recommendation;Records;Research;Resources;Risk;rural Americans;rural area;Rural Community;rural counties;Rural Health;Sampling;Schools;sexual risk behavior;simulation;social;social integration;Social Network;Specific qualifier value;Stress;Structural Racism;Structure;Students;substance use;System;Taxes;Techniques;Testing;Theoretical model;theories;twelfth grade;Uncertainty;United States;United States National Institutes of Health;young adult

PROJECT_TITLE: A community driven modeling approach for identifying community & policy-level interventions to address the impact of structural racism and discrimination on adolescent substance use and mental health

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Diffuse midline glioma (DMG) is a lethal form of brain tumors that occurs in the brain stem region of children and young adults. DMG is an exceptionally challenging cancer to treat because of its unique cellular features and location, resulting in a median survival time of 9-12 months and a 5-year survival rate that is nearly 0%. This proposal aims to develop drug delivery technologies that can facilitate mRNA therapies for DMG.

PI_NAMEs: YERNENI, SAIGOPALAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Advisory Committees;Aggressive course;Antibodies;Antigens;base;Biodistribution;Biology;Blood;blood-brain tumor barrier;Brain;Brain Diseases;Brain Neoplasms;Brain Stem;cancer therapy;career;Cell Membrane Permeability;Cells;Central Nervous System;Cessation of life;Chemistry;Child;Childhood Brain Neoplasm;Childhood Glioma;Clinic;Clinical;combat;Committee Members;COVID-19 vaccine;Data;Development;diffuse midline glioma;Disease;Disease Progression;Drug Delivery Systems;efficacy evaluation;efficacy testing;Enzymes;Epigenetic Process;epigenetic silencing;extracellular vesicles;Fellowship;Foundations;gene therapy;gene-targeted therapy;Genes;Genetic Transcription;genome editing;Goals;H3 K27M mutation;Histone H3.3;Immunocompetent;in vivo;insight;Institution;Intrabody;Knowledge;Lipid Chemistry;lipid nanoparticle;Location;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Medicine;Mentors;Mentorship;Messenger RNA;Microglia;Modification;mouse model;mRNA delivery;Mutation;nanoparticle delivery;novel therapeutic intervention;nucleic acid delivery;oncohistone;Patients;Penetration;Pharmaceutical Preparations;Phase;Pontine structure;Postdoctoral Fellow;pre-clinical;Prognosis;Proteins;Radiation therapy;Radiation Tolerance;Reporter;Research Proposals;Safety;Site;Sphingolipids;standard of care;Survival Rate;System;targeted delivery;Technology;technology platform;Testing;Therapeutic;therapeutic RNA;Therapeutic Uses;Time;trafficking;Training;Transfection;Translating;Translations;tumor;Universities;young adult

PROJECT_TITLE: Enabling mRNA Therapies for Pediatric High-Grade Gliomas

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a deadly under-recognized disease characterized by high blood pressure in the lungs and right heart failure. While there are several medicines available to treat PAH, none cure the disease nor address right heart failure directly. In this proposal, we will conduct a clinical trial to determine if a new class of drugs called sodium glucose co-transporter 2 inhibitors, currently used to treat diabetes and heart failure, will improve right heart function and outcomes in PAH.

PI_NAMEs: HERESI DAVILA, GUSTAVO ADOLFO (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acetylcarnitine;Address;Adipose tissue;Affect;Animals;Anti-diabetic Drugs;arm;Attenuated;Biological Markers;Blood capillaries;Brain natriuretic peptide;burden of illness;Cardiac;cardiac magnetic resonance imaging;Cause of Death;Cessation of life;Clinical;Clinical Trials;clinically relevant;Conduct Clinical Trials;Coupling;cytotoxic;Data;Death Rate;Deterioration;Development;Diabetes Mellitus;diet and exercise;Dietary Intervention;Disease;drug action;Dyslipidemias;Echocardiography;Excess Mortality;exercise intervention;experience;fatty acid oxidation;Fatty Acids;fluorodeoxyglucose positron emission tomography;Glucose;Glucose Intolerance;glucose uptake;Goals;Heart;Heart failure;heart function;heart imaging;High Density Lipoprotein Cholesterol;Human;Hypertension;improved;inhibitor;Insulin Resistance;Intervention;Left;Left Ventricular Ejection Fraction;Lipids;Lung;lung pressure;Masks;Measures;Medical;Medicine;Metabolic;Metabolism;Metformin;N-terminal;new therapeutic target;novel drug class;Outcome;outcome prediction;Palmitates;Patient Outcomes Assessments;Patients;Phase II Clinical Trials;Phase III Clinical Trials;Phenotype;Placebos;Plasma;Positron-Emission Tomography;premature;primary endpoint;Production;pulmonary arterial hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;Quality of life;Randomized;Reporting;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Right ventricular structure;Risk;Safety;secondary endpoint;Sodium;Stroke Volume;subcutaneous;Survival Rate;symporter;targeted treatment;Testing;Time;treatment response;Vasodilator Agents;Ventricular;Ventricular Ejection Fractions;Walking;Work

PROJECT_TITLE: 1/2 Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (MA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE  Rising syphilis cases have led to shortages in the treatment of choice ‐ single‐dose intramuscular penicillin – leading to increased reliance on multiday therapy with doxycycline, since high rates of drug resistance preclude use of azithromycin as an alternative single‐dose therapy. This proposal outlines development and validation of two complementary types of molecular tests to detect genotypic determinants of drug resistance to azithromycin and doxycycline which could be applied at the point of patient care to inform antibiotic therapy and for public health monitoring of emerging doxycycline resistance. The point‐of‐care strategy will develop an allele‐speciﬁc variant of a rapid, Loop‐mediated isothermal ampliﬁcation (LAMP) assay developed by our laboratory to detect Treponema pallidum, the etiologic agent of syphilis; a second, complementary approach will develop an amplicon‐next‐generation sequencing assay for detection of T. pallidum drug resistance in the clinical laboratory.

PI_NAMEs: LIEBERMAN, JOSHUA ABRAHAM (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Alleles;alternative treatment;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Azithromycin;azithromycin resistance;Binding;Biological Assay;Certification;CLIA certified;Clinical;clinical diagnostics;Complex;cost;design;Detection;detection assay;Development;diagnostic strategy;Diagnostic tests;disparities in morbidity;Distal;dosage;Dose;Doxycycline;Drug resistance;ethnic minority;Etiology;False Negative Reactions;fetal;follow-up;Genotype;Geographic Locations;Goals;Gram-Negative Bacteria;Growth;Health;health disparity;Hot Spot;improved;Individual;Infection;Intramuscular;isothermal amplification;Laboratories;Link;Macrolide-resistance;Macrolides;marginalized population;Mediating;men who have sex with men;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;mortality disparity;multiplex assay;Mutation;Mutation Detection;neonate;next generation sequencing;novel;Nucleic Acids;Nucleotides;optimal treatments;Order Spirochaetales;Organism;pathogen;Patient Care;Patient Compliance;Patient Selection;Patients;Penicillins;Pharmaceutical Preparations;Point Mutation;point of care;point of care testing;point-of-care detection;Population;Population Surveillance;pre-exposure prophylaxis;Predisposition;pregnant;pressure;prevent;Procedures;Prophylactic treatment;Protocols documentation;Public Health;racial health disparity;racial minority;Recommendation;Recording of previous events;Resistance;resistance mutation;resistant strain;Reverse Transcription;Risk;rRNA Genes;Signal Transduction;Single Nucleotide Polymorphism;Site;Specificity;success;surveillance study;Syphilis;Testing;Tetracyclines;Therapeutic;Time;Tissues;tool;treatment choice;Treponema pallidum;Treponema pallidum subspecies pallidum;United States;Validation;Variant;Work

PROJECT_TITLE: Rapid Point-of-Care Detection of T. pallidum Resistance to Macrolides and Tetracyclines by Multiplexed Loop-mediated amplification (LAMP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (M1)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PUBLIC HEALTH SIGNIFICANCE Triple negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer with low survival rate and limited therapeutic options and therefore, novel and effective therapies are urgently needed for TNBC treatment. We discovered that PBK kinase is a driver of anoikis resistance, a cell state that promotes TNBC tumor growth and metastasis, and thus, the studies in this proposal aim to establish PBK as a driver of TNBC tumor growth and metastasis, and establish small-molecule inhibitor of PBK kinase as novel and efficacious therapeutic agents for TNBC treatment.

PI_NAMEs: GUPTA, ROMI  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: American;Anchorage-Independent Growth;Anoikis;Apoptosis;Automobile Driving;Basic Science;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;breast malignancies;cancer subtypes;Cancerous;Cells;Clinic;Clinical;Development;Diagnosis;Disease;Distal;Doxycycline;Drug Targeting;effective therapy;Epithelial Cells;ERBB2 gene;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Genes;Genetic;Goals;Growth;Human;improved;in vivo;Injections;kinase inhibitor;knock-down;lifetime risk;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Measures;Mediating;Medical;Mesenchymal;Modeling;Molecular;Monitor;mouse model;National Cancer Institute;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;non-genetic;novel;novel therapeutics;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;PDZ-binding kinase;Pharmaceutical Preparations;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;Precision therapeutics;Process;Prognosis;Protein Kinase;Public Health;Recurrent disease;Regulatory Pathway;Relapse;Resistance;RNA interference screen;Role;Sampling;small hairpin RNA;small molecule inhibitor;subcutaneous;Survival Rate;Testing;Therapeutic;Therapeutic Agents;therapeutic target;transcription factor;triple-negative invasive breast carcinoma;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;tumor xenograft;TWIST1 gene;United States;Woman;Xenograft procedure

PROJECT_TITLE: A novel cellular identity regulatory pathway that drives anokis resistance-mediated TNBC growth and metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Rapid fluctuations in the strength of synaptic connections in the brain underlie the complex patterns of neural activity which drive all behaviors including those that require the retrieval of stored information in memories. Therefore, understanding how synapses operate is crucial to our understanding of cognitive deficits associated with aging and aging-related neurological disorders. In this project we will determine how the properties of synaptic connections directly map onto cognitive processes that allow us to separate similar instances in episodic memory.

PI_NAMEs: ARMSTRONG, JOHN NORMAN;CONTRACTOR, ANIS  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;Affinity;Aging;aging related;Animals;Axon;Behavior;Binding;Brain;Brain region;Cells;Characteristics;Code;Cognitive;Cognitive deficits;cognitive process;Complex;conditional knockout;Custom;Data;dentate gyrus;design;Educational process of instructing;Electrophysiology (science);Endowment;Environment;Episodic memory;Excitatory Postsynaptic Potentials;Frequencies;Glutamates;Goals;granule cell;hippocampal pyramidal neuron;Hippocampus;Immediate-Early Genes;Impairment;In Vitro;information processing;Interneurons;Kinetics;knockout animal;Maps;Measures;Mediating;Memory;Mental Depression;mossy fiber;Mus;Nervous System Disorder;neural circuit;neural patterning;Neurons;neurotransmitter release;novel;patch clamp;Pattern;Performance;Play;postsynaptic;presynaptic;Property;Proxy;Pyramidal Cells;Regulation;Retrieval;Role;sensor;Signal Transduction;Slice;Space Perception;Synapses;Synaptic plasticity;Synaptic Transmission;synaptotagmin VII;Task Performances;teacher;Testing;tool;touchscreen;transmission process;Work

PROJECT_TITLE: A dynamic synaptic sensor controlling hippocampal CA3 circuit function

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_DEPT: GENETICS

PHR: Contact PD/PI: Vollger, Mitchell PROJECT NARRATIVE This research aims to decode the regulatory elements in fast-evolving regions of the human genome, segmental duplications, shedding light on their roles in human evolution and susceptibility to diseases. By understanding these genetic components, the findings could pave the way for novel therapeutic targets and improved health outcomes. Ultimately, this project seeks to enhance knowledge about the functional contribution of duplications to the human genetic makeup, with the potential to uncover mechanisms of disease and adaptation in these unique regions. 1

PI_NAMEs: VOLLGER, MITCHELL R. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acceleration;Address;Adenine;Architecture;Area;Behavior;Biological Assay;career development;Chromatin;Chromatin Fiber;Chromosome Mapping;Code;cohort;Collaborations;Computing Methodologies;Detection;Development;Disease;DNA;Elements;Epigenetic Process;epigenetic variation;Evolution;Exclusion;Exhibits;Fiber;Foundations;Gene Duplication;Gene Expression Regulation;Gene Family;Genes;Genetic;genetic makeup;Genetic Variation;Genome;genome-wide;Genomic Segment;genomic tools;Genomics;Goals;Graph;Haplotypes;Health;Human;Human Genetics;Human Genome;human pangenome;human tissue;improved;Individual;insight;Investigation;Knowledge;Light;machine learning framework;Maps;Measures;Methyltransferase;Mission;neglect;neurogenesis;new therapeutic target;novel;novel therapeutics;Outcome;pan-genome;paralogous gene;Pattern;personalized medicine;Phase;Play;Population;Positioning Attribute;Predisposition;preservation;programs;Property;Proteins;Regulatory Element;Repetitive Sequence;Research;Research Design;Research Methodology;Role;single molecule;Source;statistics;Technology;telomere;Time;Tissues;tool;trait;Variant;Work

PROJECT_TITLE: The regulatory landscape of segmentally duplicated genes:  Implications for human evolution and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (KR)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Follicular lymphoma is the most common indolent non-Hodgkin lymphoma, and while it has a highly variable clinical course, advanced stage patients requiring treatment who have an early clinical failure (within 2 years of diagnosis) have very poor outcomes. We have identified a tumor gene expression signature that can be used at diagnosis to predict early clinical failure and propose to conduct both analytic and clinical validation in order to improve clinical trials and care of patients with follicular lymphoma.

PI_NAMEs: CERHAN, JAMES R;RIMSZA, LISA  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Accreditation;Age;Algorithms;anti-CD20;assay development;Biological Assay;biomarker discovery;Biometry;Biopsy;burden of illness;Cause of Death;CLIA certified;Clinic;Clinical;clinical care;clinical practice;clinical predictive model;clinical risk;Clinical Trials;Clinical Trials Cooperative Group;Development;Diagnosis;digital;Disease;Disease Progression;Disease remission;Enrollment;Epidemiology;ethnic diversity;Ethnic Origin;Event;Excess Mortality;experience;Failure;Follicular Lymphoma;Formalin;Gene Expression Profile;Gene Expression Profiling;General Population;genome-wide;Geography;Goals;Guidelines;high risk;hospital laboratories;Immuno-Chemotherapy;improved;Incidence;Indolent;Infrastructure;innovation;International Prognostic Index;Laboratories;Life Expectancy;Lymphoma;Maintenance Therapy;migration;Modeling;Monoclonal Antibody CD20;nano-string;Non-Hodgkin's Lymphoma;observational cohort study;Outcome;Paraffin Embedding;Pathology;Patient Care;patient population;patient stratification;Patients;Performance;Phase;Phase III Clinical Trials;Population;predictive modeling;prognostic model;prognostic value;Race;racial diversity;Regimen;Reproducibility;research clinical testing;Resources;Retreatment;Risk;risk prediction;risk stratification;rituximab;sex;Southwest Oncology Group;Specialized Program of Research Excellence;standard of care;Subgroup;Survival Rate;Technology;Test Result;Testing;Time;Tissue Embedding;Tissues;tool;Training;Treatment-related toxicity;trial design;tumor;Tumor Burden;Validation

PROJECT_TITLE: Assay Development and Prognostic Model for Predicting Early Clinical Failure in Follicular Lymphoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-8 (M2)]


NIH_SPENDING_CATS: Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Pregnancy represents a unique physiological situation in which the mother harbors within her a genetically foreign fetus. We propose to study how the mother’s immune system is balanced to prevent rejection of the fetus while guaranteeing the mother’s health and lifetime reproductive success. The studies will provide novel insights into the regulation of the immune system and into disorders of pregnancy such as preeclampsia.

PI_NAMEs: LAKKIS, FADI G. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Allogenic;Animals;Applications Grants;Attention;Binding;CD47 gene;CD47-SIRPα;Clinical;cohort;Conflict (Psychology);Conflict of Interest;cost;Disease;Equilibrium;fetal;Fetal Growth;Fetus;fitness;Future;Genes;Genetic;genetic regulatory protein;health of the mother;Histology;Human;Immune;immune activation;Immune response;Immune system;Immunologics;Immunologist;immunoregulation;insight;Invaded;Investments;Link;Macrophage;Macrophage Activation;maternal immune system;Maternal-Fetal Exchange;member;monocyte;Mothers;Mus;Myeloid Cell Activation;Myeloid Cells;Nature;novel;Nutrient;offspring;Organ Transplantation;Outcome;Pathology;Physiological;Placenta;Play;Pre-Eclampsia;predicting response;Pregnancy;pregnancy disorder;prevent;PTPNS1 gene;receptor;reproductive;reproductive success;Resources;response;Risk;Shapes;Signal Transduction;Spiral Artery of the Endometrium;success;Testing;Transplantation;trophoblast

PROJECT_TITLE: Innate Allorecognition at the Maternal-Fetal Interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]