ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE / PROJECT NARRATIVE SARS-CoV-2 infection in immunosuppressed individuals with HIV can lead to intra-host emergence of multi- mutational SARS-CoV-2 variants, some at sites linked to immune evasion or cell-receptor binding, especially in case of persistent infection. Phylodynamic and artificial intelligence can consider the evolutionary scenarios of SARS-CoV-2 variants emergence within HIV infection and assess the probability for increased strain infectivity and/or pathogenicity, thus providing a tool for planning and implementing public health measures before transmission occurs in the general population.

PI_NAMEs: ALCAIDE, MARIA LUISA;JONES, DEBORAH LYNNE;PROSPERI, MATTIA ;SALEMI, MARCO  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Affect;Amino Acids;Artificial Intelligence;artificial intelligence algorithm;Automobile Driving;Biological;Cessation of life;chronic infection;Cities;Classification;Clinical;Clinical Data;Clinical Management;co-infection;cohort;comparison control;Coronavirus;Country;COVID-19;COVID-19 burden;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;COVID-19 vaccination;Data;Databases;deep learning;deep learning model;Disease;Eligibility Determination;Epidemic;Epidemiologic Monitoring;Event;Evolution;experience;Florida;General Population;genomic epidemiology;Glycoproteins;Goals;Herd Immunity;HIV;HIV Infections;HIV Seronegativity;Hospitalization;Immune Evasion;Immune System Diseases;Immunocompromised Host;immunosuppressed;Incidence;Individual;Infection;infection rate;Investigation;Language Development;Learning;Link;Longitudinal cohort;Measures;Methods;Modeling;Molecular Epidemiology;mortality;multidisciplinary;Mutation;novel;Outcome;Participant;Pathogenesis;Pathogenicity;Patients;Pattern;Persons;Population;Population Dynamics;Probability;Public Health;public health relevance;receptor binding;Receptor Cell;Recording of previous events;recruit;Reporting;Research Personnel;saliva sample;Sampling;SARS-CoV-2 B.1.617.2;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 variant;severe COVID-19;Site;Surveys;Testing;tool;Training;transmission process;United States;unvaccinated;Vaccinated;Vaccination;vaccine effectiveness;vaccine hesitancy;Vaccines;Variant;variants of concern;Viral

PROJECT_TITLE: A Phylodynamic Artificial Intelligence framework to predict evolution of SARS-CoV-2 variants of concern in Immunocompromised persons with HIV (PhAI-CoV)


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Epidemiological studies identify that nonalcoholic steatohepatitis (NASH), a cell death and inflammation- associated nonalcoholic fatty liver disease (NAFLD), is the leading cause of hepatocellular carcinoma (HCC) and end-stage liver failure worldwide. The goal of this study is to investigate the role of the innate immune sensor cGAMP synthase (cGAS) in limiting tissue injury, improving tissue microenvironment homeostasis, and thus preventing nonalcoholic steatohepatitis. Identification of new drug targets and elucidating their mechanisms of action are critical for developing effective therapeutic treatment for liver metabolic diseases.

PI_NAMEs: BAI, JULI  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adipocytes;Apoptosis;Apoptotic;Binding;Biology;Cell Death;cell injury;Cell membrane;Cells;Cessation of life;chemokine;Chronic;Cyclic GMP;cytokine;Development;Diet;diet-induced obesity;Disease;DNA;DNA Binding;ds-DNA;Ectopic Expression;end stage liver disease;enzyme activity;epidemiology study;Equilibrium;Event;Fibrosis;Goals;Guanosine Triphosphate;Hepatocyte;Homeostasis;Immune;immune activation;Immune signaling;immunoregulation;Impairment;improved;In Vitro;in vivo;Inflammation;injured;innate immune pathways;innate immune sensing;Innate Immune System;Insulin Resistance;Knock-out;Kupffer Cells;Link;Liver;Liver diseases;Liver Fibrosis;liver inflammation;Macrophage;Mediating;Membrane;Metabolic Diseases;Molecular;monocyte;Mus;Natural Immunity;Nature;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Organ;Outcome;Pathogenesis;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Phagocytosis Induction;Phagosomes;Pharmaceutical Preparations;Phase;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;Play;Population;prevent;Primary carcinoma of the liver cells;protective pathway;recruit;Regulation;Rest;Role;sensor;Signal Transduction;spatiotemporal;Stimulator of Interferon Genes;SYK gene;Testing;Therapeutic;therapeutically effective;Thinking;tissue injury;Tissues

PROJECT_TITLE: Innate Immunity in NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) conducts collaborative research in innovative regulatory science. This research enhances the FDA’s public health mission including the evaluation of safe and effective medical products. In addition, the CERSI develops training and outreach programs for the purpose of training students, postdoctoral fellows and career scientists in regulatory sciences.

PI_NAMEs: ALTMAN, RUSS BIAGIO;GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: UCSF-Stanford Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: This proposal will study regulation of osteoblasts by the adrenal-stimulating hormone, adrenocorticotropic hormone, and by vascular endothelial growth factor, which is produced in new bone in response to adrenocorticotropic hormone. In bone, vascular endothelial growth factor promotes formation and support of blood vessels and prevents tissue death (osteonecrosis), including osteonecrosis in response to corticosterod treatment, which is a common clinical problem. Specifically, the work will determine the concentrations and time course by which adrenocorticotrophic hormone supports vascular endothelial growth factor production. This will be studied in living rabbits, and in human bone cell cultures in tissue culture.

PI_NAMEs: BLAIR, HARRY COLBERT (contact)

PROJECT_TERMS: Acetates;Adrenal Cortex Hormones;Adrenal Glands;Animal Model;autocrine;Blood capillaries;Blood Vessels;bone;bone cell;Bone Growth;bone mass;Bone necrosis;bone turnover;Cell Culture Techniques;Cell Proliferation;Cells;Cessation of life;Circadian Rhythms;Clinical;Complex;Corticotropin;Corticotropin Receptors;cytokine;Dependence;Differentiation and Growth;Dose;Endothelial Growth Factors Receptor;Feedback;femur head;Frequencies;Glucocorticoids;Hormones;Hour;Human;human disease;human model;Hypoxia;Immune;In Vitro;in vivo;Inflammatory;Injections;innovation;Lymphocyte;Macrophage;Measures;Mediating;Mesenchymal Stem Cells;Metabolic;Methods;Methylprednisolone;Modeling;Mus;novel;Oryctolagus cuniculus;Osteoblasts;Pathway interactions;Pituitary Gland;prevent;Production;Regulation;Regulatory Pathway;response;Serum;Signal Transduction;Steroids;substantia spongiosa;System;T-Lymphocyte;Time;tissue culture;Tissues;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Regulation of Osteoblasts by ACTH and VEGF


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Many gene mutations have been identified as causing cardiac diseases, but this information is of limited use without a detailed understanding of the mechanisms that relate genotype and phenotype. As an example of how these types of gaps can be bridged, we are developing biophysically detailed multiscale models that predict the impact of actin thin filament mutations on cardiac cell hypertrophy. These predictions will be validated against experiments and refined to create a robust tool for classifying pathogenicity of novel sarcomeric variants.

PI_NAMEs: CAMPBELL, STUART G (contact);LEHMAN, WILLIAM J;MOORE, JEFFREY R

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Actins;Algorithms;Amino Acids;Behavior;Benchmarking;Benign;Binding;Biological Assay;Biophysics;Cardiac;cardiac tissue engineering;Cardiomyopathies;Cells;Classification;Clinical;clinical decision support;clinical decision-making;Clinical Management;Clinical Research;ClinVar;Complex;computational pipelines;Computer Models;Computing Methodologies;Data;Databases;design;Disease;disease-causing mutation;Early Diagnosis;Early identification;Ensure;Evaluation;experience;experimental study;Family;Funding;Gene Mutation;Genes;Genetic Screening;genetic testing;genetic variant;Genotype;Goals;Health;Heart;Heart Diseases;Human;Human Engineering;Hypertrophy;In Vitro;Individual;Induced Mutation;interest;Link;link protein;Maps;Measurable;Methods;Modeling;Molecular;molecular dynamics;Motility;multi-scale modeling;Muscle Contraction;Muscle function;Mutation;novel;Outcome;Pathogenicity;Patients;Phenotype;Population;predictive modeling;protein protein interaction;Proteins;Publishing;rational design;Regulation;Risk;risk stratification;Role;Sarcomeres;Structural Models;Subcellular structure;Symptoms;Testing;Thin Filament;tool;Tropomyosin;Troponin;Troponin I;Troponin T;Variant;variant of unknown significance;Work

PROJECT_TITLE: Computational Pipeline for Identification of Disease-Causing Variants in Genes of the Cardiac Sarcomere

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on discovery of novel signaling pathways that drive castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NIH's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LIU, XIAOQI  (contact);YANG, HSIN-SHENG

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: abiraterone;Ablation;Agreement;androgen independent prostate cancer;Androgen Receptor;Androgens;Apoptosis;Binding;Biochemical;Biometry;Cancer Patient;Castration;Cell Cycle;Cells;Chemoresistance;Clinical Research;Clinical Trials;clinically significant;Complex;Creativeness;Data;design;Development;Disease;docetaxel;Dominant-Negative Mutation;Down-Regulation;Drug resistance;effective therapy;enzalutamide;Event;Fostering;FRAP1 gene;genetic approach;Genetically Engineered Mouse;Goals;Growth;Health;Human;improved;in vivo;inhibitor;innovation;Investigation;Knock-out;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Mission;mouse model;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;Outcome;Pathology;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peptides;Pharmaceutical Preparations;Phosphorylation;Play;PLK1 gene;programmed cell death protein 1;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;protein degradation;Proteins;Public Health;receptor expression;Receptor Signaling;Regulation;Reporting;Repression;Research;Resistance;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;success;System;Tertiary Protein Structure;Testing;Therapeutic;tumor growth;tumor initiation;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Work proposed here will explore the activity of a promising metabolic inhibitor against the amoebae, defining the suspected cellular target, testing new analogs of the parent inhibitor, and assessing the impact of the agent in a rodent model of disease. The described work is the first step in maturing the compounds into treatment of pathogenic free-living amoebae Naegleria fowleri infection. We will use a combination of biochemical, medicinal chemical, and model animal experiments to score the impact of enolase inhibitors developed for use in humans against the amoebae and to assess the role of the immune system in the treatment regime.

PI_NAMEs: MORRIS, JAMES CULVIN (contact);MOSEMAN, E. ASHLEY ;WHITEHEAD, DANIEL CHARLES

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Amoeba genus;analog;Animals;Biochemical;Biological Assay;Body Weight decreased;Cells;cellular targeting;Chemicals;Collection;Continuous Infusion;Death Rate;Development;disease model;Drug Design;Engineering;enolase;Enzyme Inhibition;Enzymes;Experimental Animal Model;experimental study;Genetic;Glioblastoma;glucose metabolism;Goals;Human;Human Cell Line;Immune;Immune response;Immune system;improved;In Vitro;in vivo;Infection;inflammatory marker;inhibitor;insight;Lead;Mammals;Medicine;Metabolic;Metabolism;Monitor;mouse model;Naegleria;Naegleria fowleri;neoplastic cell;nonhuman primate;novel;novel therapeutics;Outcome;Parasites;Parents;Pathogenicity;Pathologic;Pathway interactions;pharmacokinetics and pharmacodynamics;phosphonate;Phosphonic Acids;primary amebic meningoencephalitis;Probability;Protein Isoforms;Proteins;Proteome;Reagent;Rodent Diseases;Rodent Model;Role;Series;Specificity;Structure;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;tool;Toxic effect;treatment response;Work

PROJECT_TITLE: Enolase inhibitors as therapeutic leads for Naegleria fowleri infections

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE The treatment of severe infections caused by methicillin-susceptible Staphylococcus aureus (MSSA) has undergone an important paradigm shift since cefazolin is now considered, by many, the front-line antibiotic. However, therapeutic success of severe MSSA infections treated with cefazolin may be affected by the cefazolin inoculum (CzIE) effect, leading to poor outcomes. Our proposal seeks to determine the clinical impact of the CzIE and provide clinically relevant novel diagnostic tools to identify this phenotype with the objective of optimizing the treatment of life-threatening MSSA infections.

PI_NAMEs: ARIAS, CESAR AUGUSTO (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adverse reactions;Affect;Antibiotics;arm;Attention;Australia;Bacteremia;beta-Lactamase;beta-Lactams;Biological;Blood Circulation;Canada;Cefazolin;Cephalosporins;Child;Chile;Clinical;Clinical Data;Clinical Microbiology;clinically relevant;Colombia;cost;Data;Detection;diagnostic tool;Early Diagnosis;Effectiveness;effectiveness evaluation;Enrollment;Failure;Floxacillin;Generations;Genomics;Genus staphylococcus;Geographic Locations;Goals;Hepatotoxicity;high risk;human pathogen;Infection;insight;Interstitial Nephritis;Israel;Laboratories;Latin America;Life;Mediator;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Methodist Church;minimal inhibitory concentration;Minimum Inhibitory Concentration measurement;mortality;Nafcillin;Nature;Neutropenia;New Zealand;nitrocefin;novel;novel diagnostics;open label;Osteomyelitis;Outcome;Oxacillin;participant enrollment;pathogen;Patient-Focused Outcomes;Patients;Penicillins;Performance;Pharmaceutical Preparations;Phenotype;Prevalence;primary outcome;Production;public health relevance;Publishing;Randomized;rapid detection;rapid test;Reaction;recruit;Rest;Retrospective Studies;Risk;Risk Factors;Safety;Sample Size;secondary outcome;Sensitivity and Specificity;Sepsis;Singapore;Specific qualifier value;Staphylococcus aureus;Staphylococcus aureus infection;success;Test Result;Testing;Therapeutic;treatment optimization;United Kingdom;United States

PROJECT_TITLE: Clinical Impact of the Cefazolin Inoculum Effect

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because pancreatic cancer patients have a dismal chance of survival secondary to tumor resistance to standard chemo and immunotherapies because of the immunosuppressive tumor microenvironment. In this proposal, we will determine how an epigenetic regulator, KMT2D, regulates the tumor microenvironment via activin A and contributes to pancreatic cancer progression. Our project will contribute to impactful new knowledge on the influence of tumor cell-intrinsic epigenetic signaling on tumor microenvironment and tumor progression, which will pave the way for the clinical development of novel tumor microenvironment-targeting treatment in combination with chemo or immunotherapies for pancreatic cancer patients.

PI_NAMEs: SHI, JIAQI  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: activin A;Activins;Animal Model;Biological Assay;cancer cell;Cancer Etiology;cancer genetics;cell behavior;Cell Line;Cells;Cessation of life;Characteristics;ChIP-seq;clinical development;Coculture Techniques;cofactor;CRISPR/Cas technology;cytokine;Cytometry;Data;Development;effector T cell;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Failure;Fibroblasts;Future;Genetic;Genetic Transcription;Goals;Grant;histone modification;Immune;Immunohistochemistry;Immunologics;Immunotherapy;improved;Infiltration;Inflammatory;innovation;knock-down;Knock-out;Knowledge;KRAS2 gene;Ligands;loss of function mutation;Luciferases;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mutation;Myeloid-derived suppressor cells;Neoadjuvant Therapy;neoplastic cell;novel;Pancreas;pancreas development;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway interactions;Patients;preclinical development;Preclinical Testing;Prognosis;programs;protein expression;Public Health;receptor;Regulation;Reporter;Research;Resistance;response;Role;Secondary to;Shapes;Signal Transduction;single-cell RNA sequencing;T cell infiltration;T-Cell Activation;T-Lymphocyte;Technology;Testing;therapy resistant;three dimensional cell culture;three-dimensional modeling;transcription factor;Transcriptional Regulation;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Defining epigenetic signaling to reshape pancreatic tumor microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-R(02)M]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Back Pain;Biomedical Imaging;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Histone deacetylase (HDAC) enzymes are key components regulating gene expression in response to life experience and have recently being associated with the development and maintenance of pain. We propose to use a newly developed PET radiotracer, [11C]Martinostat, to quantify the distribution and availability of HDACs in the brain of chronic low back pain patients with and without taking prescription opioids and to evaluate sex differences. We will clarify HDAC enzymes as a relevant target relating to chronic pain and opioid use.

PI_NAMEs: WEY, HSIAO-YING  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Absence of pain sensation;Address;Adult;Affect;Age;Aging;Alzheimer's Disease;Amygdaloid structure;Analgesics;Animal Model;Animals;Area;Astronomy;Autopsy;Basic Science;Behavior;Binding;Blood;Brain;Brain Diseases;Brain region;brain tissue;Cells;Chromatin;Chronic;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;Clinical;clinical imaging;Cognition;cohort;Complex;conditioned place preference;Control Groups;cost;Data;Development;Disease;DNA;Drug Targeting;Environment;Enzymes;epigenetic drug;Epigenetic Process;Female;Functional disorder;Gene Expression;gene repression;Gene Silencing;Genes;Genetic Code;Genetic Markers;Goals;HDAC1 gene;HDAC2 gene;Healthcare;Heroin;Hippocampus;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;Histone Deacetylation;Histones;Human;Human Volunteers;Hydrocodone;Image;imaging agent;imaging study;improved;Income;Individual;Inflammatory;Investigation;kinetic model;Knowledge;Lead;Learning;Life Experience;Long-Term Effects;Magnetic Resonance Imaging;Maintenance;male;Malignant Neoplasms;Measures;Mediating;Mediator;Memory;Mental Depression;Mental disorders;mental function;Modeling;Morphine;Motor Activity;Nerve;neural;Neurodegenerative Disorders;neurodevelopment;Neuronal Plasticity;Neuropathy;novel;Opiate Addiction;Opioid;opioid use;Outcome Measure;Oxycodone;Pain;Pain management;pain model;pain patient;Pathogenesis;Patient Selection;Patients;Phase;Physical Function;Play;Positron-Emission Tomography;pre-clinical;prescription opioid;Process;Productivity;promoter;Proteins;Quality of life;radiotracer;Regulation;Research;Research Design;response;Rodent;Rodent Model;Role;Schizophrenia;Sex Differences;small molecule;Spinal Cord;success;System;Thalamic structure;Therapeutic;Tissue Sample;Translating;United States;Update;uptake;Validation;Ventral Tegmental Area;visual map;Visualization;Women's prevalence

PROJECT_TITLE: Neuroepigenetic mechanisms of chronic low back pain using histone deacetylases PET imaging


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Decline in NAD+ levels contributes to the progression of heart failure. SARM1 NAD+ hydrolase is known as an executor of axonal degeneration, but its role in the heart has not been described. This proposal will determine the mechanistic roles of SARM1 activation in NAD+ decline and mitophagy during metabolic cardiomyopathy.

PI_NAMEs: LEE, CHI FUNG  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Area;axon injury;axonal degeneration;Binding;Biosensor;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cause of Death;Cell Death;Cells;Consumption;Cytosol;Data;desensitization;diabetes control;diabetic;diabetic cardiomyopathy;diet-induced obesity;Disease;Functional disorder;Future;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;Hydrolase;inhibitor;Insulin-Dependent Diabetes Mellitus;Knockout Mice;Link;MAPK8 gene;Measures;Mediating;Metabolic;Metabolic Activation;Metabolic stress;metabolome;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Mitochondrial Proteins;Modeling;multiple omics;Mus;neuron loss;Neurons;new therapeutic target;Niacinamide;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outer Mitochondrial Membrane;Parkin;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phosphorylation;Phosphorylation Site;PINK1 gene;prevent;protein biomarkers;Proteins;Proteome;recruit;Recycling;Reporting;Research;Role;Signal Transduction;Sterility;Stress;Stress cardiomyopathy;Therapeutic;therapeutic development;Transcript;transcriptome

PROJECT_TITLE: Roles of SARM1 NAD hydrolase in metabolic cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Cystic Fibrosis;Digestive Diseases;Genetics;Liver Disease;Lung;Orphan Drug;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Cystic fibrosis (CF)-related liver disease (CFLD) is the third-leading cause of mortality in CF, an autosomal genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In the present work, we propose studies to use our newly developed rabbit CF model to preclinically test potential therapeutic effects of the sodium-dependent glucose cotransporter (SGLT) inhibitors on CFLD.

PI_NAMEs: XU, JIE  (contact);ZHANG, KEZHONG

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adverse effects;airway epithelium;Animal Model;Animals;Attenuated;autosome;Base Pairing;Bile Acids;Bile fluid;biological adaptation to stress;Biological Models;Blood Chemical Analysis;blood glucose regulation;Cells;cholangiocyte;Clinical;Code;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Diabetes Mellitus;Disease;disease phenotype;drug development;drug testing;efficacy testing;endoplasmic reticulum stress;Epithelial Cells;Exclusion;experimental study;extend lifespan;Follow-Up Studies;Genetic Diseases;Glucose;Goals;Hepatocyte;Human;Impairment;improved;Individual;Inflammation;inhibitor;inhibitor therapy;Knowledge;Lipids;Liver;liver cystic fibrosis;Liver diseases;Liver Fibrosis;liver function;Lung;Medical;Metabolic Diseases;Modeling;Molecular;mortality;Mutation;nonalcoholic steatohepatitis;Organoids;Oryctolagus cuniculus;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;Pre-Clinical Model;Preclinical Testing;pulmonary function;Regulator Genes;Reporting;Research Priority;RNA Splicing;Safety;Sodium;symporter;Testing;Therapeutic Effect;Tissues;Transducers;United States Food and Drug Administration;Up-Regulation;Weight Gain;Work;XBP1 gene

PROJECT_TITLE: Targeting SGLTs for liver disease in a rabbit model of cystic fibrosis

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Despite the clinical importance, the neural mechanisms of abnormal mechanosensation associated with dry eyes or contact lens wear remain unknown due to a lack of knowledge about primary mechanosensitive fibers involved. This proposal will characterize the role of MrgprD-expressing sensory fibers in mediating ocular mechanosensation and their regulation of lacrimation. These studies will not only advance our understanding of ocular sensation of dryness at the molecular and cellular levels, but will also provide a new neuronal target for promoting lacrimation under dry eye conditions.

PI_NAMEs: LIU, QIN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Ablation;Address;Adopted;Affect;Afferent Neurons;Anatomy;Axon;Behavioral;blink reflexes;Blinking;bodily sensation;Calcium;Chemicals;Clinical;conjunctiva;Contact Lenses;Cornea;Crystalline Lens;Data;Detection;Dissociation;Dryness;Esthesia;evaporation;Exclusion;experimental study;Eye Development;eye dryness;Eye Movements;Fiber;Film;Foreign Bodies;Friction;Funding;Genetic;genetic approach;Image;Imaging Techniques;In Vitro;insight;Knowledge;Label;Lacrimation;Lubrication;Mechanics;Mediating;Molecular;mouse genetics;mouse model;nerve supply;neural;neuromechanism;Neurons;neurosensory;novel;ocular surface;ocular surface disease;Pathologic;Pattern;Periodicals;pharmacologic;Physiological;Pilot Projects;Population;Property;Regulation;Research;Role;Saccades;Sensory;Structure of palpebral conjunctiva;Testing;Therapeutic;Viscosity;Wild Type Mouse

PROJECT_TITLE: The Neural Basis of Ocular Sensations


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Low oxygen tension, despite being a distinguishing trait of solid tumors, is rarely recapitulated in preclinical cancer research leading to the investigation of less-representative signaling pathways and the omission of hypoxia induced sensitivities and resistances to pharmalogical intervention. This proposal describes completed and ongoing pre-doctoral efforts to uncover actionable targets of tyrosine kinase signaling pathways that emerge during hypoxia and in hypoxic metastatic niches, as well as future post-doctoral efforts to investigate the impact of hypoxia induced tyrosine phosphatase (PTP) inactivation. Further, since PTPs restrain cellular signaling, identification of emergent sensitivities due to the loss of PTP activity may result in the identification of biological mechanisms amenable to therapeutic exploitation that have been not captured in previous normoxic efforts.

PI_NAMEs: MAYRO, BENJAMIN JACOB (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 2-tyrosine;ABL1 gene;ABL2 gene;Ablation;Animal Model;anti-cancer research;autocrine;Biological;Brain;brain parenchyma;cancer cell;cancer therapy;career;Cell Hypoxia;Cells;Cellular biology;Characteristics;Clinical Trials;Dasatinib;Data;Dependence;Development;Disseminated Malignant Neoplasm;Doctor of Philosophy;effective therapy;efficacious treatment;Environment;FDA approved;Fellowship;Foundations;Future;Genetic Transcription;Gleevec;high-throughput drug screening;HSF1;Hypoxia;Impairment;improved;In Vitro;in vivo;inhibitor;Intervention;Investigation;leukemia;Luciferases;Lung Adenocarcinoma;lung cancer cell;lung colonization;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Mediating;Metastatic malignant neoplasm to brain;Modality;molecular targeted therapies;Nature;Neoplasm Metastasis;oxidation;Oxygen;Patient-Focused Outcomes;Patients;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;Phosphotyrosine;Play;Postdoctoral Fellow;pre-clinical;pre-doctoral;preclinical study;Principal Investigator;programs;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Proto-Oncogene Proteins c-abl;Reporter;Reporting;Research;Research Project Grants;Resistance;response;restraint;Role;Sampling;Signal Pathway;Signal Transduction;skills;small molecule;Solid Neoplasm;targeted treatment;Technology;Therapeutic;Time;Training;trait;transcription factor;Translating;Trastuzumab;tumor;tumor hypoxia;tumor microenvironment;tumor progression;Tumor-Associated Process;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;ubiquitin-protein ligase;Work

PROJECT_TITLE: Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Nutrition;Obesity;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Eating disorders and substance abuse are significant health risks that involve brain reward circuitry; tying these together is our discovery that insulin, a recognized regulator of satiety and metabolism, is also a reward signal in the brain. This project will assess mechanisms underlying increased release of acetylcholine and dopamine in striatal slices and in vivo, evaluate nutrient learning behaviors that are reinforced by insulin and blunted by a high-fat high-sugar diet, and combine these approaches to assess insulin-dependent synaptic plasticity. Proposed studies will show how the nutritive value of what we eat affects striatal cells and circuits to influence future food choices, and investigate the potential of new pharmacological targets that could be used to break the cycle of over-eating and obesity.

PI_NAMEs: CARR, KENNETH D;RICE, MARGARET E (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acetylcholine;Address;Affect;antagonist;Axon;behavioral study;Biochemical;blood-brain barrier crossing;Brain;Bypass;Cells;cholinergic;Companions;Consummatory Behavior;Consumption;Corpus striatum structure;Data;detection of nutrient;Diet;Disabling;Dopamine;dopaminergic neuron;Dorsal;Eating;Eating Disorders;Electrophysiology (science);Elements;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Female;Fiber;Food;Future;Globus Pallidus;Glucose;Goals;Health;Healthy Eating;Hyperphagia;Hypothalamic structure;Impairment;in vivo;Incentives;Insulin;Insulin Receptor;insulin signaling;Intake;Interneurons;Intervention;Knockout Mice;Label;Lateral;learned behavior;Learning;Liquid substance;Literature;male;Metabolic hormone;Metabolism;Microinjections;Midbrain structure;Monitor;Motivation;Mus;N-Methylaspartate;Neuromodulator;Neurons;Nicotinic Receptors;Nucleus Accumbens;Nutrient;Nutritive Value;Obesity;Output;Pathway interactions;Pattern;pharmacologic;Photometry;Pilot Projects;Population;Potassium Channel;preference;prevent;Rattus;reinforced behavior;Reporting;Resolution;reward circuitry;Rewards;Risk;Rodent;Role;Satiation;Signal Transduction;Slice;Structure;Substance abuse problem;sugar;Synapses;synaptic depression;Synaptic plasticity;Testing;Training;Whole-Cell Recordings;Work

PROJECT_TITLE: Diet, Insulin, Dopamine, and Reward

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN DIEGO

ORG_NAME: CALIFORNIA MEDICAL INNOVATIONS INSTITUTE

PHR: PROJECT NARRATIVE We seek to understand the chronic effects of cardiac resynchronization therapy (CRT), HIS bundle pacing and left branch bundle pacing under ischemic condition, which we will apply it to optimize CRT. The completion of this proposal may significantly improve heart HF outcome and cost of management.

PI_NAMEs: KASSAB, GHASSAN S (contact);LEE, LIK CHUAN

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Algorithms;Animal Model;Animals;Blood Vessels;Bundle-Branch Block;Cardiac;cardiac resynchronization therapy;Cardiovascular system;Chronic;Cicatrix;Clinic;Clinical;clinically relevant;computational platform;computer framework;Computer Models;Coronary;coronary perfusion;Coronary sinus structure;cost;Coupling;Development;Disadvantaged;Disease;Effectiveness;Electrophysiology (science);Epidemic;Geometry;Goals;Growth;Health Care Costs;Heart;Heart Diseases;Heart failure;hemodynamics;Histology;improved;Infarction;innovation;Intraventricular;Ischemia;Knowledge;Left;Location;Long-Term Effects;Machine Learning;machine learning algorithm;Maps;mathematical model;Measures;Mechanics;Methodology;Modeling;Morphology;mortality;novel;novel strategies;Outcome;Patients;Pattern;Perfusion;Physics;Physiological;Positioning Attribute;premature;preservation;Property;Purkinje Cells;Recommendation;Reperfusion Therapy;response;Role;Severities;Spatial Distribution;Structure of purkinje fibers;Subendocardial Layer;success;Surface;System;Time;Translating;treatment optimization;treatment response;Ventricular;Work

PROJECT_TITLE: Mathematical Model-Based Optimization of CRT Response in Ischemia

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Psychosis;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Pregnant women and their fetuses are exposed to multiple environmental insults during gestation, a very influential period for the fetal developing brain; prenatal exposures have been linked to increased cognitive, behavioral, and emotional problems including self-regulation, attention, conduct, and substance use problems, and psychotic experiences. Using a cognitive neuroscience approach, we seek to understand how in utero exposure to complex environmental mixtures alters the function of brain circuits that support cognitive control and reward processing, and gives rise to a range of behaviors that commonly emerge in late childhood and adolescence, a period that has been largely understudied with respect to the effects of prenatal exposures on neurodevelopmental outcomes. Our findings will allow public health interventions to improve the quality of children's perinatal environment and the development of novel circuit-specific intervention tools.

PI_NAMEs: MARGOLIS, AMY  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 17 year old;Address;Adolescence;Affect;Amygdaloid structure;Animals;Aromatic Polycyclic Hydrocarbons;associated symptom;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior assessment;Behavior Therapy;Behavioral;Behavioral Symptoms;Biological;Birth;Brain;brain pathway;Chemical Exposure;Chemicals;Child;Childhood;Clinical;Cognitive;cognitive control;cognitive neuroscience;cohort;Collaborations;Complex;Complex Mixtures;Data;Development;Diagnosis;Diagnostic;Disease;disorder risk;Dorsal;early life exposure;early life stress;Emotional;Ensure;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;environmental tobacco smoke;Etiology;experience;Exposure to;fetal;Fetus;Functional Magnetic Resonance Imaging;Genetic;Health;health of the mother;high dimensionality;high risk;Human;Impairment;improved;in utero;Inferior frontal gyrus;Influentials;Informal Social Control;Interdisciplinary Study;Intervention;Joints;K-Series Research Career Programs;Knowledge;Learning;Life;Link;maladaptive behavior;Mediating;Mental disorders;Mental Health;Methods;Mothers;National Institute of Environmental Health Sciences;neural;neural circuit;Neural Pathways;neurobehavioral;neurodevelopment;Neuroepidemiology;neuroimaging;Neurophysiology - biologic function;Neurotoxins;Newborn Infant;novel;Outcome;Pathway interactions;Pattern Recognition;Performance;perinatal environment;phthalates;Population;Pregnancy;Pregnant Women;prenatal;prenatal environmental exposure;prenatal exposure;Principal Investigator;Process;psychiatric symptom;Psychological reinforcement;psychotic;Psychotic Disorders;public health intervention;Quality of life;Research;Research Project Grants;Resolution;Rest;reward processing;Rewards;Risk;social;social stressor;statistical and machine learning;Substance abuse problem;substance use;Substance Use Disorder;success;Symptoms;Techniques;Testing;Time;tool;trait;Variant

PROJECT_TITLE: Prenatal Environmental Mixtures, Cognitive Control and Reward Processes, And Risk for Psychiatric Problems in Adolescence.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Heart disease is the leading cause of mortality worldwide and disruption of transcription in the heart contributes to the progression of heart disease. This application will investigate basic mechanisms of transcription in the heart by determining how transcriptional complexes work and how mutations in these complexes contribute to development of heart disease. Consequently, a better understanding of the molecular mechanisms governing cardiac gene expression will provide new insight into therapeutic strategies to restore cardiac function during disease.

PI_NAMEs: BASKIN, KEDRYN K (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Architecture;Binding;Biological Assay;Calcium;Cardiac;Cardiac Myocytes;Cells;ChIP-seq;Chromatin;chromosome conformation capture;clinically relevant;cohesin;Complex;Coupled;CREB1 gene;Data;Development;Disease;experimental study;Gel Chromatography;Gene Expression;Gene Expression Regulation;Genes;Genetic Models;Genetic Transcription;Genomics;Goals;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;human induced pluripotent stem cells;Individual;insight;Knock-out;Link;Mediating;Mediator;Missense Mutation;Modeling;Molecular;mortality;Multiprotein Complexes;Mus;Mutation;novel;overexpression;Phosphotransferases;Population;programs;Proteins;Publishing;Reporter;Reporter Genes;Reporting;Repression;RNA Polymerase II;Role;Serum Response Factor;Testing;Therapeutic;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Transgenic Model;Transgenic Organisms;Work

PROJECT_TITLE: Transcriptional Coordination and Gene Regulation by MED12 in the Cardiomyocyte


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Lung;Orphan Drug;Rare Diseases

PHR: Narrative: New therapeutics are needed to decrease the burden of acute respiratory distress syndrome. The tRNA methyltransferase TRMT1 is a critical regulator of the innate immune response to bacterial infection through the modification of tRNA. In these experiments we examine the molecular regulation of TRMT1 and the role of tRNA methylation during the inflammatory response, a mechanism that has not been studied in lung injury.

PI_NAMEs: LONDINO, JAMES DAVID (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Admission activity;Affect;alveolar epithelium;Bacterial Infections;Behavior;Biological;Biology;Cell Death;Cell Survival;Cells;Cellular Stress;Cessation of life;Clinical Trials;Complication;Critical Care;Critical Illness;cytokine;Cytoplasm;Data;Development;Disease;Edema;Environment;Enzymes;epithelial injury;Experimental Models;experimental study;gain of function;Gases;Genetic Transcription;Global Change;Host Defense;Human;Immune system;immunopathology;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Intensive Care Units;Intervention;Investigation;Knock-out;loss of function;Lung;lung injury;Macrophage;Measures;Mediating;Messenger RNA;Methylation;Methyltransferase;Mitochondria;Modification;Molecular;molecular modeling;monocyte;mortality;Myelogenous;Natural Immunity;new therapeutic target;novel;novel therapeutics;Patients;Peripheral Blood Mononuclear Cell;Pneumonia;Post-Translational Protein Processing;posttranscriptional;Production;Proteins;Reactive Oxygen Species;Regulation;Resolution;response;RNA;RNA methylation;RNA Stability;RNF139 gene;Role;Signal Transduction;Small Interfering RNA;Specificity;Stimulus;targeted treatment;Tissues;trafficking;Transfer RNA;Translations;tRNA Methyltransferases;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Examining the role of TRMT1 and tRNA methylation in acute lung injury and ARDS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative T helper type 2 (Th2) cells are a type of effector CD4T cells that plays a crucial role in allergic diseases as well as in host protection against parasitic pathogens, but how they develop from naive CD4T cells upon encountering an allergen or parasitic antigen remains unclear. CD301b+ dendritic cells (DCs) are both necessary and sufficient for inducing Th2 differentiation of antigen-specific CD4T cells, and our data suggest contact-dependent interaction between these two cell types as the key mechanism for the Th2 fate decision by CD4T cells. To understand the mechanism of Th2 cell differentiation, this grant application proposes to precisely characterize the mechanisms and consequences of the interaction between CD301b+DCs and CD4T cells, which overall would help us to understand the basic mechanism of adaptive immunity and to improve our strategies for treating allergic diseases and developing effective vaccines for infectious diseases.

PI_NAMEs: KUMAMOTO, YOSUKE  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: adaptive immunity;Address;Allergens;Allergic Disease;Antigen Presentation;Antigen-Presenting Cells;Antigens;Applications Grants;Back;Cell Differentiation process;cell type;Cells;collaborative environment;Communicable Diseases;Core Facility;Cues;Data;Dendritic Cells;Dermis;Differentiation Antigens;Disease;Effector Cell;Equipment;Event;experimental study;Exposure to;Focus Groups;genetic manipulation;Goals;HDAC7 histone deacetylase;helminth infection;Helminths;Helper-Inducer T-Lymphocyte;Homologous Gene;Hookworms;Human;Humoral Immunities;Hypersensitivity;IL2RA gene;Immune;Immune response;Immunity;immunopathology;imprint;improved;in vivo;Infection;Inflammation;Instruction;Interleukin-12;Interleukin-2;interleukin-23;Kinetics;Ligation;Lung;Mediating;Modeling;Molecular;mouse model;Nippostrongylus;novel;Organ;Papain;Parasitic infection;pathogen;Peptide Hydrolases;Peripheral;Phenotype;Play;Regulation;response;Role;Scanning;selective expression;Signal Pathway;Signal Transduction;Skin;skin hypersensitivity;Supporting Cell;Testing;Th2 Cells;Therapeutic;TNFRSF5 gene;Up-Regulation;vaccine development;Vaccines

PROJECT_TITLE: Regulation of Th2 differentiation by skin-resident dendritic cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Millions of individuals suffer from pain and loss of function due to conditions like stroke, osteoarthritis, low back pain, cerebral palsy, and age-related frailty. Rehabilitation can improve function and quality of life, but current rehabilitation practice requires in-person guidance by a skilled clinician, increasing expense and limiting access. This project will provide vital research infrastructure and training opportunities, bringing together researchers from rehabilitation medicine, computer science, and bioengineering who are applying mobile technology to revolutionize how we diagnose, monitor, and treat mobility limitations.

PI_NAMEs: DELP, SCOTT L (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Acceleration;age related;Area;Award;Biomechanics;Biomedical Engineering;Caring;Cellular Phone;Cerebral Palsy;Clinic;Clinical;Collaborations;Communication;Communities;community center;computer science;computer scientist;Computer software;Data;data hub;Data Science;Data Set;data sharing;Degenerative polyarthritis;design;Diagnosis;Educational process of instructing;Engineering;experience;Faculty;Fostering;frailty;functional improvement;Funding;Generations;Goals;Grant;Human;improved;Individual;Industry;Infrastructure;innovation;insight;interdisciplinary collaboration;knowledgebase;Leadership;loss of function;Low Back Pain;massive open online courses;member;mHealth;Mission;mobile computing;mobile sensor;Monitor;Movement;new technology;novel;online resource;Online Systems;open source;Outcome;Outcome Measure;outreach program;Pain;Parkinson Disease;Patient Care;Patient Recruitments;Patients;Persons;Physical Medicine;physical therapist;Physical therapy;Physicians;Pilot Projects;Postdoctoral Fellow;programs;Protocols documentation;Quality of life;rat Ran 2 protein;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Running;Scholars Program;Scientist;sensor;sensor technology;shared repository;skills;Software Tools;Standardization;statistics;Stroke;stroke-like outcome;symposium;Talents;technique development;tool;Training;Training and Infrastructure;training opportunity;Translating;Travel;visiting scholar;wearable data;wearable sensor technology

PROJECT_TITLE: Center for Reliable Sensor Technology-Based Outcomes for Rehabilitation (RESTORE)


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: KU, JOY P (contact)

PROJECT_TERMS: Acceleration;Algorithms;Area;Award;Biomechanics;Biomedical Engineering;biomedical scientist;Caring;Cerebral Palsy;Client;Clinical;Collaborations;Communities;community center;computer science;computer scientist;Computer software;Data;data cleaning;Data Science;Data Set;data sharing;Degenerative polyarthritis;design;Devices;Discipline;Distance Learning;Documentation;Education;Educational process of instructing;Educational workshop;effectiveness evaluation;Engineering;Evaluation;Event;experience;Exposure to;Faculty;Feedback;Fostering;Foundations;frailty;Generations;Goals;Grant;improved;Individual;Industry;innovation;insight;interdisciplinary collaboration;knowledgebase;Leadership;Letters;Libraries;Low Back Pain;Machine Learning;massive open online courses;Mentors;mHealth;Mission;mobile computing;mobile sensor;Monitor;Movement;neurological rehabilitation;new technology;open source;Outcome;outreach program;Parkinson Disease;Participant;Patient Care;patient engagement;Patient Recruitments;Patients;Physical Medicine;physical therapist;Physical therapy;Physicians;Pilot Projects;Process;Production;programs;Published Comment;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;rehabilitation technology;Rehabilitation therapy;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Robotics;Rotation;Running;Sampling;Scientist;sensor technology;shared repository;simulation;Software Tools;Specialist;statistics;Stroke;Students;Surveys;symposium;Talents;Technology;Time;tool;Training;Training and Infrastructure;Training Programs;Translating;Translations;Travel;Universities;user-friendly;Validation;wearable data;wiki

PROJECT_TITLE: Didactic Interaction


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebral Palsy;Cerebrovascular;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

PROJECT_TERMS: Acceleration;Area;artificial intelligence method;Award;biomechanical model;Biomechanics;Biomedical Engineering;Caregivers;Caring;Cartilage;Cellular Phone;Cerebral Palsy;Child;Classification;Clinic;Clinical;clinical outcome measures;Clothing;Collaborations;Communities;community center;complex data;computer science;computer scientist;Computer software;Data;Data Collection;data hub;Data Science;Data Set;data sharing;Degenerative polyarthritis;design;Elderly;Engineering;Environment;Ethics;experience;Fostering;frailty;functional improvement;Gait;Generations;Goals;Grant;heart rate monitor;Human;improved;Individual;Industry;innovation;insight;instrument;interdisciplinary collaboration;Intervention;Knee;knowledgebase;Leadership;Location;Low Back Pain;Machine Learning;machine learning model;massive open online courses;Measurement;Measures;mHealth;Mission;mobile computing;mobile sensor;Modeling;Monitor;Movement;Nature;new technology;novel strategies;open source;Operative Surgical Procedures;Outcome;Outcome Measure;Output;outreach program;Parkinson Disease;Patient Care;patient population;Patient Recruitments;Patients;Performance;Physical activity;Physical Medicine;physical therapist;Physical therapy;Physicians;Population;Population Heterogeneity;post stroke;predict clinical outcome;Protocols documentation;Public Health;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Running;Scientist;sensor;sensor technology;shared repository;smart watch;smartphone application;software development;Software Tools;Spinal Stenosis;statistics;Stroke;symposium;Talents;technique development;Technology;Technology Assessment;technology development;Testing;tool;Training;Training and Infrastructure;Translating;usability;Validation;wearable data;wearable device;wearable sensor technology;web site

PROJECT_TITLE: Technology Development


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Asthma is a common, chronic disease in both children and adults that is characterized by wheezing, shortness of breath, and coughing. Treatments for asthma are designed to control symptoms by relaxation of airway smooth muscle. Our work focuses on understanding how G protein coupled receptor signaling pathways coordinate airway smooth muscle functions with the long term goal of identifying new targets for treatment of this important clinical problem.

PI_NAMEs: OSTROM, RENNOLDS S;PENN, RAYMOND B.;RICH, THOMAS C (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: A kinase anchoring protein;Adenylate Cyclase;Adult;Affect;Agonist;airway hyperresponsiveness;airway inflammation;airway remodeling;Arrestins;Asthma;asthmatic;Basic Science;Biology;Biosensor;Cell membrane;Cell Nucleus;Cell Physiology;Cell Separation;Cells;Characteristics;Child;Chronic Disease;Clinical;Coughing;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;design;Disparate;Dissociation;Elements;EP4 receptor;Exhibits;experimental study;Foundations;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic regulatory protein;Goals;Grant;grasp;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;Image;imaging approach;Imaging Techniques;insight;Integral Membrane Protein;Intracellular Membranes;Kinetics;knock-down;Knowledge;Link;Location;mathematical model;Measures;Mediating;Membrane Microdomains;Methodology;migration;Molecular Biology;Muscle Cells;Muscle Contraction;Muscle function;new therapeutic target;novel;Outcome;overexpression;Pathway interactions;Phospholipase C;Phosphoproteins;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;preservation;Protein Isoforms;protein protein interaction;Proteins;Proteome;receptor;Receptor Signaling;Regulation;Relaxation;respiratory smooth muscle;response;Role;Second Messenger Systems;Shapes;Shortness of Breath;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;spatiotemporal;Specificity;stoichiometry;subcellular targeting;Symptoms;System;Testing;tool;Visualization;Wheezing;Work

PROJECT_TITLE: Compartmentalized signaling and crosstalk in airway myocytes

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: HICKS, JENNIFER LEE (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Area;Award;Biomechanics;Biomedical Engineering;Caliber;career;Caring;Cerebral Palsy;Clinical;Collaborations;Communities;community center;computer science;computer scientist;Computer software;Computing Methodologies;Data;Data Science;Data Set;data sharing;Degenerative polyarthritis;design;Discipline;Emerging Technologies;Engineering;Ensure;experience;Feedback;Fostering;Foundations;frailty;Funding;Future;Generations;Goals;Grant;improved;Individual;Industry;innovation;insight;Institution;interdisciplinary collaboration;interest;Knowledge;knowledgebase;Lead;Leadership;Low Back Pain;massive open online courses;Measurement;Measures;meetings;Mentors;Mentorship;mHealth;Mission;mobile computing;mobile sensor;Monitor;Movement;new technology;open source;Outcome;Outcomes Research;outreach program;Parkinson Disease;Patient Care;Patient Recruitments;Patients;Physical Medicine;physical therapist;Physical therapy;Physicians;Pilot Projects;Process;programs;Publications;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;rehabilitation technology;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Running;Scientist;sensor;sensor technology;Series;shared repository;Software Tools;statistics;Stroke;Surveys;symposium;Talents;tool;Training;Training and Infrastructure;Translating;Travel;United States National Institutes of Health;videoconference;wearable data

PROJECT_TITLE: Pilot Studies


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Data Science;Disability Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;Ally;American;Apple;Area;Artificial Leg;Attention;Award;Awareness;Biomechanics;Biomedical Engineering;Caring;Cerebral Palsy;Clinical;Collaborations;Communication;Communities;community center;computer science;computer scientist;Computer software;Congresses;Data;data hub;Data Science;Data Scientist;Data Set;data sharing;Degenerative polyarthritis;design;Development;Devices;Disabled Persons;Discipline;Effectiveness;Electronic Mail;Engineering;Ensure;Equity;ethnic minority;Event;experience;fitbit;Fostering;frailty;Future;Generations;Goals;Grant;Human;improved;Incentives;Individual;Industrialization;Industry;innovation;insight;interdisciplinary collaboration;Joints;knowledgebase;Leadership;Libraries;Low Back Pain;Machine Learning;massive open online courses;Medical center;member;mHealth;Minority Groups;Mission;mobile application;mobile computing;mobile sensor;Monitor;Movement;new technology;Newsletter;Nonprofit Organizations;open source;Outcome;outreach program;Parkinson Disease;Patient Care;Patient Recruitments;Patients;Persons;Physical Medicine;physical therapist;Physical therapy;Physicians;Problem Solving;Professional Organizations;programs;Prosthesis;racial minority;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Running;Scientist;sensor technology;shared repository;Site;social media;Software Tools;statistics;Stream;Stroke;symposium;System;Talents;Technology;Technology Assessment;tool;Touch sensation;Training;Training and Infrastructure;Translating;Underrepresented Minority;United States National Institutes of Health;Visit;Walking;wearable data;wearable sensor technology;web site;Woman;Work

PROJECT_TITLE: Promoting Center Expertise


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative  Cells must coordinate multiple independent processes during division to ensure that each daughter cell faithfully inherits the genome and all essential compartments to maintain viability. This proposal aims to study the novel role of the separase pathway, essential for chromosome segregation, in the regulation of cortical granule exocytosis in C. elegans oocytes. The control of disparate processes by core cell cycle regulators enables cells to synchronize mitotic events to maintain the fidelity of cell division.

PI_NAMEs: BEMBENEK, JOSHUA NATHANIEL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Affect;Alleles;Anaphase;anaphase-promoting complex;Binding;Biochemical;Caenorhabditis elegans;Cell Compartmentation;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Cellular biology;Chromosome Segregation;Chromosomes;cohesin;Complex;Cytokinesis;Cytoplasmic Granules;Data;daughter cell;Development;Disease;Disparate;Embryo;Enzymes;Event;Exocytosis;Fertilization;Funding;Genetic;genetic approach;Genome;Goals;Heat-Shock Proteins 90;In Vitro;Infertility;Inherited;insight;Knowledge;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Meiosis;Membrane;Mitotic;Molecular Chaperones;mutant;Mutation;novel;Oocytes;overexpression;Pathway interactions;Peptide Hydrolases;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;prevent;Process;Protein Dephosphorylation;PTTG1 gene;Regulation;Regulation of Exocytosis;Regulatory Pathway;Role;segregation;separase;Series;Sister Chromatid;Testing;tool;trafficking;Vesicle;Work

PROJECT_TITLE: Cell Cycle Regulation of Membrane Trafficking

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


PROJECT_TERMS: Acceleration;Area;Award;Biomechanics;Biomedical Engineering;career;Caring;Cerebral Palsy;Clinical;cohesion;Collaborations;Communication;Communities;community building;community center;computer science;computer scientist;Computer software;Data;data hub;Data Science;Data Set;data sharing;Degenerative polyarthritis;design;Devices;Discipline;Effectiveness;Elements;Engineering;Ensure;Event;experience;Faculty;Fostering;frailty;Funding;Generations;Goals;Grant;Health Sciences;improved;Individual;Industry;industry partner;Infrastructure;innovation;insight;interdisciplinary collaboration;Joints;knowledge hub;knowledgebase;Leadership;Libraries;Low Back Pain;massive open online courses;Mentors;mHealth;Mission;mobile computing;mobile sensor;Monitor;Movement;new technology;novel;open source;Outcome;Outcome Measure;outreach program;Parkinson Disease;Patient Care;Patient Recruitments;Patients;Physical Medicine;physical therapist;Physical therapy;Physicians;Pilot Projects;Policies;Process;programs;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;research study;Research Training;Resource Development;Resources;Rewards;Running;Scholars Program;Scientist;sensor technology;shared repository;Software Tools;statistics;Stroke;success;symposium;synergism;Talents;technology development;Testing;tool;Training;Training and Infrastructure;Translating;United States National Institutes of Health;visiting scholar;wearable data;wearable sensor technology;web site;Work

PROJECT_TITLE: Administrative Oversight


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: PROJECT NARRATIVE  Associations between the senses of smell and taste (i.e., flavors) are an essential factor in determining which foods we choose to eat; however, the neural mechanisms underlying the multisensory integration of odors and tastes remain unclear. We use a combination of behaving electrophysiology and optogenetics to investigate how interactions between the olfactory and gustatory cortices contribute to multisensory integration of smell and taste. These results will provide new insight into the circuit mechanisms underlying the perception of flavor.

PI_NAMEs: SAMUELSEN, CHAD L (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Neural mechanisms underlying integration of taste and smell

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: PROJECT NARRATIVE Impaired energy homeostasis contributes to cardiomyocyte damage and adverse cardiovascular outcomes after myocardial infarction or circulatory arrest. We have discovered a new mechanistic pathway that controls cardiac glucose metabolism under ischemic stress. This project will delineate critical molecular aspects of the pathway and its role in the pathogenesis of ischemic heart disease.

PI_NAMEs: YOSHIOKA, JUN  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adaptor Signaling Protein;aerobic glycolysis;Arrestins;Artificial Intelligence;beta-adrenergic receptor;beta-arrestin;Binding;Binding Proteins;Biochemical;Biological Assay;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular system;Cell Death;Cell Physiology;Cell Survival;Cells;Clathrin;Complex;Computer Analysis;CRISPR/Cas technology;Cytoprotection;Data;Defense Mechanisms;desensitization;drug discovery;Endocytosis;Environment;experimental study;Family;Gene Silencing;Genes;genetic manipulation;Genetic Transcription;Genome engineering;Glucose;glucose metabolism;glucose transport;Glucose Transporter;glucose uptake;Glycolysis;Heart;Homeostasis;Hypoxia;Impairment;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;insight;Ischemia;Knock-out;Knockout Mice;Knowledge;knowledge of results;Link;Mediating;member;Membrane;Metabolic;Metabolism;Molecular;mouse model;Mus;mutant;Myocardial;Myocardial Infarction;Myocardial Ischemia;Nature;neoplastic cell;novel;novel therapeutics;Nutrient;Outcome;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Physiological;Proteins;receptor;receptor function;reconstitution;Regulation;Reporting;Role;Scaffolding Protein;Signal Transduction;SLC2A1 gene;small molecule;Specificity;Starvation;Stress;Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;trafficking;TXNIP gene;ubiquitin-protein ligase;Ubiquitination;virtual screening;Warburg Effect;Wild Type Mouse

PROJECT_TITLE: Arrestin domain-containing protein 4 as a novel regulator of glucose metabolism in the ischemic heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our long-term goal is to develop and implement a novel biophotonics imaging tool for intraoperative detection of positive tumor margins during breast conserving surgery. The imaging device we propose to develop will be practically designed and validated for use in a surgical setting. The imaging device is significantly relevant to public health in that it will significantly reduce the unnecessary additional surgery for women who undergo breast conserving surgery.

PI_NAMEs: YE, DONG HYE ;YU, BING  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Adopted;Algorithms;Area;Biophotonics;Biopsy Specimen;Breast Cancer Cell;breast lumpectomy;Breast-Conserving Surgery;cancer cell;Cancer Detection;cancer invasiveness;cancer recurrence;cancer risk;cancer surgery;Caregivers;Cells;Classification;classification algorithm;Clinical;Collection;Color;Computer software;contrast enhanced;Cosmetics;cost;Data;deep learning;deep neural network;design;Detection;Development;Devices;Dyes;Emerging Technologies;Emotional;Eosine Yellowish;Evaluation;Excision;Financial Hardship;fluorescence imaging;Frozen Sections;Goals;Guidelines;Head and Neck Cancer;Healthcare Systems;Histologic;Human;Image;Imaging Device;imaging modality;improved;Infiltration;innovation;instrument;Lighting;lost work time;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measurement;Microscope;Microscopic;Microscopy;Motor;motor control;new technology;Normal tissue morphology;novel;Operating Rooms;Operative Surgical Procedures;Optics;Pathologic;Patients;pilot test;Propidium Diiodide;Prostate;Public Health;Publications;radiological imaging;Recommendation;Resolution;Sampling;Scanning;Sensitivity and Specificity;Site;Specificity;Specimen;Speed;Surface;Surgeon;System;technology platform;Testing;Time;Tissue Sample;Tissues;Touch sensation;Training;transfer learning;tumor;ultraviolet;Ultraviolet Rays;Validation;Variant;Woman;women's diagnosis

PROJECT_TITLE: Deep learning enabled, deep ultraviolet scanning microscopy for intraoperative assessment of margin status during breast cancer surgery

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: || NARRATIVE Endothelial cells line the inside of blood vessels and provide barrier integrity to regulate the amount of fluid that moves between the inside and outside of blood vessels. Fluid leakage out of the vasculature is a major complication of inflammation that often leads to a lethal systemic bacterial infection known as sepsis. Fluid leak occurs mostly in veins, where most of the blood resides. We will study how inflammatory signals induce changes in proteins that regulate the veinous endothelial barrier to identify targets with the ability to control sepsis.

PI_NAMEs: ISAKSON, BRANT E (contact);KOVAL, MICHAEL H.

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adenosine;Affect;Bacterial Infections;Binding;Blood;Blood capillaries;blood pressure regulation;Blood Vessels;Calcium;Calmodulin;Cardiovascular system;Cations;Caveolae;caveolin 1;Caveolins;cecal ligation puncture;Cell Adhesion;Cell Culture Techniques;Cell Line;Cell membrane;cell type;Certification;Cessation of life;Complex;Complication;Coupled;Cues;cytokine;Data;Development;Diagnosis;Disease;Edema;Endocytosis;Endothelial Cells;Endothelium;Endotoxins;Etiology;Extravasation;factor A;Funding;Genes;Genetic;Hand;Health;Heterogeneity;Hospitals;Human;Inflammation;Inflammatory;insight;Intervention;Knockout Mice;Knowledge;Liquid substance;Measures;member;Membrane Microdomains;Modeling;Modification;Molecular;mouse model;Mus;mutant;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Oxidation-Reduction;Pathologic;Pathway interactions;Perfusion;Permeability;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphorylation Site;Phosphotransferases;Point Mutation;Post-Translational Protein Processing;Process;Productivity;Property;Proteins;Purines;receptor;Recycling;Regulation;Research;Research Personnel;response;Role;Sepsis;septic;Severities;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Specificity;Stimulus;Testing;Tight Junctions;TNF gene;trafficking;Translating;Translations;Tyrosine;United States;Vascular Permeabilities;Veins;Venous;Work;World Health Organization

PROJECT_TITLE: Purinergic Regulation of Veinous Endothelial Permeability

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Emergency Care;Health Services;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The consequences resulting from trauma to older adults are magnified when compared to younger age groups, however very few high-quality studies have been conducted to describe the long-term experience of trauma from the perspective of these patients and their respective caregivers. This study will characterize the experience of older adult trauma patients and their family caregivers using a qualitative approach through concept elicitation interviews over time. The results from this study will lead to innovative intervention strategies designed to improve quality of life for older adults with traumatic injury.

PI_NAMEs: HAINES, KRISTA  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acute care;Address;Admission activity;Affect;Age;age group;Aging;Anxiety;Award;career;career development;Caregiver Burden;Caregivers;Caring;Cause of Death;Cessation of life;Climacteric;Cognitive;Complication;Critical Care;Dedications;design;Development;Disease;Elderly;Emotional;Enrollment;Ensure;expectation;experience;experimental study;Family;Family Caregiver;Family member;functional outcomes;functional status;Future;Geriatrics;Gerontology;Goals;Guilt;health care disparity;Health care facility;health related quality of life;Healthcare;Healthcare Systems;Heart Diseases;Hospitals;improved;Injury;innovation;inpatient service;instrument;Intervention;Interview;Knowledge;Lead;Length of Stay;Longitudinal Studies;Lung Diseases;Malignant Neoplasms;Measurement;Measures;Medical;Mental Depression;Mentors;Methodology;Methods;older adult;older patient;Operative Surgical Procedures;Outcome;Outcome Measure;Patient Care;patient oriented;patient oriented research;patient population;Patient-Focused Outcomes;Patients;Personal Satisfaction;Population;post-trauma;Process;professor;Program Development;prospective;Psychometrics;Qualitative Research;Quality of Care;Quality of life;Questionnaires;readmission rates;Recovery;Reporting;Research;research and development;Research Design;Research Personnel;Review Literature;Scientist;Services;severe injury;shared decision making;skills;social;Stress;success;Surgeon;Surveys;System;therapy design;Time;tool;Training;Trauma;trauma care;Trauma patient;Traumatic injury;United States;Universities;Work

PROJECT_TITLE: Longitudinal Characterization of the Older Adult Trauma Patient Experience

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: FARGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: PROJECT NARRATIVE This project will: 1) identify motivation, emotion, and health behavior pathways through which a core psychological resource (perceived control) supports cognitive functioning, and 2) determine the extent to which the protective influence of perceived control on cognition is more pronounced for populations with limited socioeconomic resources who are at increased risk of cognitive decline. We will use micro- and macro- longitudinal data to systematically test the proposed pathways linking perceived control to changes in cognitive functioning across multiple timescales (days, months, and years). Our project will identify the mechanistic pathways and socioeconomic populations for whom perceived control buffers against cognitive declines.

PI_NAMEs: HAMM, JEREMY  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: acute symptom;Address;age related;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Behavioral;Behavioral Mechanisms;Belief;Buffers;Characteristics;Cognition;Cognitive aging;cognitive function;Collection;Data;Data Analyses;Development;Disparity;Emotions;evidence base;field study;Funding;global health;Goals;Health;Health behavior;Health behavior change;Health Status;human old age (65+);Impaired cognition;Individual;innovation;Intervention;Knowledge;Link;low socioeconomic status;Measurement;Measures;Mediating;Mediation;middle age;mortality;Motivation;negative affect;older adult;Outcome;Pathway interactions;Persons;Physical activity;Population;Population Heterogeneity;preservation;Process;prospective;psychologic;Psychological Factors;Research;Research Personnel;Resources;Risk;Risk Reduction;Sampling;Scientific Advances and Accomplishments;secondary analysis;Sleep;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;Testing;therapy design;Time;United States;Work

PROJECT_TITLE: Perceived Control and Cognitive Aging: Pathways to Preserve Cognitive Functioning and Reduce Risk of Alzheimer’s Disease in Socioeconomically Diverse Populations

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative See Project Summary.

PI_NAMEs: BROW, DAVID A (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: accurate diagnosis;age related;autosome;Biological Models;Biotechnology;Blindness;Defect;Disease;disease prognosis;Enzymes;Exhibits;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Genetic Transcription;Goals;Heart;Human;Human Pathology;Informatin;Inherited;Molecular;Motor Neurons;mRNA Precursor;Mutation;neural;Neurodegenerative Disorders;novel therapeutic intervention;Nuclear;Nuclear RNA;nucleotide metabolism;Pathologic;Pathway interactions;posttranscriptional;Process;Proteins;Purine Nucleotides;Regulation;Retinal Degeneration;Retinitis Pigmentosa;RNA;RNA Polymerase II;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Saccharomyces cerevisiae;Signal Transduction;Spliceosomes;synthetic biology;Tissues;transmission process;Yeasts

PROJECT_TITLE: RNA-based mechanisms in nuclear steps of gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Lung;Regenerative Medicine

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cell death is an obligate consequence of tissue injury and fibroblasts are important cells during tissue repair. This proposal tests the hypothesis that fibroblast recognition of dead cells, termed cell corpses, promotes fibroblast repair capacity by triggering elevation of polyamine synthesis and hypusination of eiF5a, which drives fibroblast proliferation and synthesis of collagen proteins. Achieving the aims of this proposal will enhance our understanding of fibroblast-corpse interactions and the role of hypusine-eiF5a in fibroblasts and pave the way for development of novel approaches to promote lung repair.

PI_NAMEs: MCCUBBREY, ALEXANDRA LEIGH (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Alveolar;Apoptotic;Basement membrane;Binding;Biological Process;Bleomycin;Blood capillaries;Cell Death;Cell Proliferation;Cells;Coculture Techniques;Collagen;Cues;Data;deoxyhypusine synthase;Deposition;Development;eIF-5A;Enzymes;Extracellular Matrix;Fibroblasts;Gene Deletion;healing;Health;Human;hypusine;In Vitro;in vivo;Inflammation;inhibitor;Injury;Isotopes;Lipids;Liposomes;Lung;lung health;lung injury;lung repair;Macrophage;Maintenance;metabolomics;Molecular Conformation;Mus;novel;novel strategies;novel therapeutics;Ornithine Decarboxylase;Phagocytes;phosphatidylserine receptor;Phosphatidylserines;Polyamines;polyproline;prevent;Production;Proliferating;Protein Biosynthesis;Proteins;Proteomics;Pulmonary Inflammation;receptor;reconstitution;repair function;repaired;Research;response;restoration;Ribosomes;Role;scaffold;seal;Signal Transduction;Small Interfering RNA;Spermidine;Tamoxifen;Testing;tissue injury;tissue repair;transcriptome sequencing;Translations;Work;wound closure

PROJECT_TITLE: Interaction of fibroblasts with cell corpses increases collagen synthesis during lung repair


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Polyploidization, which increases the number of chromosome sets, is an alternative to cell division during tissue development and regeneration. This project aims to understand the mechanisms that mediate the cell cycle decision between division and polyploidization during epicardial regeneration. It has important, generalizable implications for how polyploidy can be controlled to improve the efficacy of the therapeutic repair of human tissues like the heart and for the treatment of diseases like cancer and acute kidney injury that involve polyploidy.

PI_NAMEs: CAO, JINGLI  (contact)

PROJECT_TERMS: Ablation;Activity Cycles;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;age-related disease;Apoptosis;Behavior;Biological Assay;Cardiac;Cardiac Myocytes;cardiac regeneration;cell behavior;Cell Cycle;Cell Cycle Regulation;Cell Density;Cell division;cell motility;Cell Proliferation;cell type;Cells;Chromosomes;Cicatrix;Cytokinesis;Defect;Development;Disease;DNA;Dominant-Negative Mutation;Epicardium;factor C;Fibroblasts;gain of function;Genes;Genetic;Genome;Heart;human tissue;improved;Injury;innovation;Knowledge;loss of function;lung injury;Malignant Neoplasms;mechanical signal;Mechanics;mechanotransduction;Mediating;migration;Molecular;Myocardium;Natural regeneration;Normal tissue morphology;novel;novel strategies;Nuclear;Organ;overexpression;paracrine;Paracrine Communication;Pathologic;Pathologic Processes;Pathway interactions;Pattern;Pericytes;pharmacologic;Pharmacological Treatment;Physiological;Polyploid Cells;Polyploidy;Population;Process;progenitor;Proliferating;Proteins;receptor;regeneration model;regenerative;Regulation;repaired;Reporter;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Source;spatiotemporal;System;Testing;tissue regeneration;tissue repair;Tissues;tool;Treatment Efficacy;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;Vegf inhibition;Work;wound;wound healing;Zebrafish

PROJECT_TITLE: Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-R(02)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: Failure to disassemble or degrade RNA and protein complexes in cells has been associated with cellular dysfunction. Evidence suggests this may influence the progression and onset of various cancers and neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). Understanding how cells can clear potentially toxic accumulations of proteins and RNA, and developing a means to boost such clearance processes, may be crucial to developing new therapeutic strategies in these disease states.

PI_NAMEs: BUCHAN, JOHN ROSS (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Affect;ALS pathology;Amyotrophic Lateral Sclerosis;Autophagocytosis;Biochemical;Biological Assay;Biology;Cell model;Cell Physiology;Cell Survival;Cells;Cellular biology;Coupled;Cytoplasm;Cytoplasmic Granules;Cytoplasmic Protein;Data;Disease;endosome membrane;Event;Excision;Failure;Functional disorder;Gene Expression;Genetic;Genetic Screening;Goals;Grant;Growth;Homeostasis;Human;Image;Impairment;Individual;innovation;Knowledge;Label;Link;Lysosomes;Malignant Neoplasms;Maps;Measures;Membrane;Messenger RNA;Methods;Microscopy;Modeling;Molecular Chaperones;molecular imaging;multicatalytic endopeptidase complex;Multivesicular Body;Mutagenesis;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Outcome;Pathology;Pathway interactions;Phenotype;Physical condensation;Physiologic pulse;prevent;Process;protein complex;protein TDP-43;Proteins;proteostasis;Regulation;Reporting;Ribonucleases;RNA;RNA Decay;RNA Stability;RNA-Binding Proteins;Role;screening;Signal Pathway;Signal Transduction;Signaling Protein;single molecule;Specificity;Stress;stress granule;Testing;Therapeutic;therapeutic target;Toxic effect;trafficking;transcriptome;transcriptome sequencing;Ubiquitin;Ubiquitination;Vacuole;Validation;Viral;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Analysis of mRNP granule clearance, vacuolar RNA decay and TDP-43 turnover

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

PHR: Project Narrative Zoonotic viruses (those transmitted from animals to humans) pose a significant threat to global public health. Traditionally, researchers have taken a retrospective approach to studying zoonosis—only after a virus has emerged in humans have we started to dissect what genetic barriers the virus faced during zoonotic transmission, and how the animal virus adapted to overcome those barriers. The goal of this proposal is to take a prospective approach to studying zoonosis, by taking a virus family of high zoonotic potential and assessing their relative risk for zoonosis using a novel experimental framework.

PI_NAMEs: WARREN, CODY JAY (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Animals;antiviral immunity;Arterivirus;Biological;Blood;Blood Circulation;cDNA Library;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;CRISPR screen;cross-species transmission;Data;Data Analyses;Disease;Dominant Genes;Ebola virus;Ecology;Epidemic;Face;Family;functional genomics;Genes;Genetic;genome analysis;genome sequencing;genome-wide;Genomic approach;Geographic Distribution;Goals;Health;High-Throughput Nucleotide Sequencing;HIV-1;Human;Infection;insight;Integration Host Factors;interest;Interferons;Investments;knock-down;Knock-out;Macrophage;Membrane Glycoproteins;Metagenomics;Middle East Respiratory Syndrome Coronavirus;Molecular Evolution;Monkeys;Mutation;Natural experiment;Natural Immunity;Natural Selections;Nature;novel;Orthologous Gene;pandemic disease;Pathogenicity;Phenotype;Play;Predisposition;prevent;Primates;Process;prospective;Proteins;Public Health;receptor;receptor binding;Relative Risks;Research Personnel;Risk;Role;SARS coronavirus;Series;Severe Acute Respiratory Syndrome;SIV;Species Specificity;success;Testing;tool;Training;transcription factor;transmission process;Viral;Viral Load result;Viral Proteins;viral transmission;Virus;Virus Diseases;virus host interaction;Virus Replication;Work;Writing;Zoonoses

PROJECT_TITLE: Identifying genetic barriers to animal virus replication in human cells: Insights into zoonosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: This proposed research is relevant to public health because drug abuse among HIV-infected individuals poses a significant health burden to the Society. One of the hallmark features of morphine abuse is augmented astrocyte activation in the setting of HIV infection. Herein, we proposed to investigate the molecular mechanisms underlying the effects of both HIV and morphine on astrocyte activation in the context of NLRP6 inflammasome signaling using various state-of-the-art approaches that could have ramifications for the future development of novel therapeutic approaches to mitigate central nervous system complications of NeuroHIV.

PI_NAMEs: PERIYASAMY, PALSAMY  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: antiretroviral therapy;Astrocytes;Biological Assay;Biological Process;bisulfite;bisulfite sequencing;Brain;brain tissue;CASP1 gene;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Central Nervous System;combinatorial;comorbidity;Confocal Microscopy;cytokine;cytotoxic;Data;demethylation;Development;Disease Progression;DNA;DNA Methylation;DNA sequencing;Down-Regulation;Drug abuse;drug of abuse;Enzyme-Linked Immunosorbent Assay;Enzymes;Epidemic;Epigenetic Process;exposed human population;Exposure to;Family;frontal lobe;Future;Gene Expression Profile;Gene Silencing;Genetic Transcription;Genomic DNA;glial activation;Goals;Health;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;IL18 gene;Immunoprecipitation;In Vitro;in vivo;Individual;Inflammasome;Inflammatory;Interleukin-1 beta;Knockout Mice;Knowledge;Lead;Luciferases;lymph nodes;Macaca mulatta;marenostrin;Mediating;Mediator;Microglia;MicroRNAs;Molecular;Morphine;Morphine Abuse;morphine administration;Mus;neuroAIDS;neuroinflammation;novel therapeutic intervention;novel therapeutics;Opioid;opioid use;Pain management;Pharmaceutical Preparations;pharmacologic;posttranscriptional;promoter;Proteins;Public Health;receptor;Reporting;Research;response;Role;Signal Transduction;Signaling Protein;SIV;Societies;tat Protein;Testing;therapy adherence;Tissues;Transgenic Organisms;Untranslated Regions;Untranslated RNA;Up-Regulation;Validation;Viral Proteins;Viremia;Western Blotting;whole genome

PROJECT_TITLE: HIV Tat and morphine-mediated pyroptosis activates astrocytes: Role of NLRP6 inflammasome in HAND

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The NUAIR T32 Fellowship program is designed for MD, MD/PhD and/or PhD trainees with an interest in advanced training in translational research in the field of Allergy-Immunology. Projects of trainees have both clinical and laboratory components, and trainees have access to renowned mentors in both clinical and basic departments in order to develop a mentoring team with expertise in both realms to successfully complete projects and training. NUAIR is highly compliant with scientific, programmatic and social initiatives of the NIAID and the NIH, and has been very successful in training academic investigators during its first two funding periods.

PI_NAMEs: BERDNIKOVS, SERGEJS ;EISENBARTH, STEPHANIE CAROLINE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Northwestern University Allergy and Immunology Research (NUAIR) Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Clinical Research

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

PHR: Project Narrative ROS and RNS production play an important role in various physiological processes (e.g. immune response, vascular regulation, neural functions) and in numerous pathological conditions. This study will provide a mechanistic understanding of how the remodeling of cellular metabolism powers up RONS production by NOXs and NOSs, and how their production causes downstream effects in metabolism and cell physiology. Such knowledge will provide a foundation to develop strategies to control RONS production or target the mechanisms for its downstream effects, which can modulate a broad range of physiological processes across tissues involving RONS production and improve the treatment of a variety of related diseases.

PI_NAMEs: FAN, JING  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acetyl Coenzyme A;arm;Automobile Driving;Biochemical;Blood Vessels;Cardiovascular Diseases;Cell Physiology;Cells;Coenzyme A;Coupled;Cysteine;Disease;electron donor;Endothelial Cells;enzyme substrate;Enzymes;Foundations;Free Radicals;genetic manipulation;glucose metabolism;Glycolysis;Histone Acetylation;Immune;Immune response;improved;Inflammation;Inflammatory;Isotopes;Ketoglutarate Dehydrogenase Complex;Knowledge;Link;Macrophage;Mediating;Metabolic;Metabolism;Mitochondria;Modification;Molecular;NADP;NADPH Oxidase;Nerve Degeneration;Neurons;Neurophysiology - biologic function;neutrophil;Nitric Oxide Synthase;Nitrogen;novel;oxidation;Oxidation-Reduction;Oxygen;Pathologic;Pentosephosphate Pathway;Periodicity;Physiological Processes;Play;Production;Proteins;pyruvate dehydrogenase;Reaction;Reactive Nitrogen Species;Reactive Oxygen Species;Recovery;Regulation;Role;Signal Transduction;Sulfhydryl Compounds;Time;Tissues

PROJECT_TITLE: Metabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE This project examines experiences of health and economic challenges during the COVID-19 pandemic across generations of American families and how families responded to these challenges. The project creates a contextual database with information on multiple domains linked to two nationally-representative surveys of extended families to describe the degree to which family members shared the same challenges during the pandemic and how this affected their ability to help each other with time, money, and shared housing. The project focuses on the pandemic’s immediate and intermediate effects on health, whether it exacerbated health disparities, and if family support mitigated negative health effects.

PI_NAMEs: WIEMERS, EMILY  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Affect;Age;American;Body mass index;Caring;Characteristics;Collaborations;combat;Communities;contextual factors;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;data dissemination;data resource;Data Set;Databases;depressive symptoms;design;Dimensions;Disadvantaged;Disparity;Economic Conditions;economic cost;economic impact;Economics;Effectiveness;Environment;Ethnic Origin;experience;Exposure to;Extended Family;Face;Family;Family dynamics;Family health status;Family member;family structure;family support;Financial Support;Gender;Generations;Goals;Health;Health and Retirement Study;health care availability;health disparity;Health protection;Household;Household and Family;Housing;Individual;Inequality;Interview;Knowledge;Life;Life Cycle Stages;Link;local economy;Measures;Medical;Medical Records;member;Mental Health;Neighborhoods;Occupations;older adult;Outcome;outcome disparities;pandemic disease;pandemic impact;pandemic response;panel study of income dynamics;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Policies;Population;Privatization;programs;prospective;Race;Records;Research;residence;Respondent;response;Retirement;Risk;Risk Factors;Role;safety net;Sampling;Schools;Severities;Sleep;social group;Socioeconomic Status;Surveys;Time;Training;Unemployment;Update;Variant;Work

PROJECT_TITLE: Tracing the Health Consequences of Family Support during the COVID-19 Pandemic