ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: QUEENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: Narrative Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) known to cause the coronavirus disease 2019 (COVID-19), has infected 24 million in the United States with approximately 400,000 deaths (as of January 20, 2021), and the number of infections and deaths are expected to significantly increase over the next few months. There is an urgent global need to develop a thermostable and self-administrable vaccine, and the spike protein presented on the surface of coronavirus is an excellent antigenic candidate in the development of a vaccine. Here, we aim to use the spike protein as an antigen and develop a novel, thermostable, and inhalable dry powder COVID-19 vaccine that is easy to scale-up, eliminates the need for cold-chain storage and transport, and is self-administrable by individuals’ at-home by simple inhalation.

PI_NAMEs: KUNDA, NITESH K (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Adjuvant;Adsorption;Aerosols;Affect;Animal Model;Antibodies;Antibody Response;Antibody titer measurement;Antigen Presentation;Antigen-Presenting Cells;Antigens;Biological Assay;booster vaccine;Cells;Cessation of life;Characteristics;Clinic;Clinical;Cold Chains;Collaborations;comorbidity;Coronavirus;COVID-19;COVID-19 vaccine;Data;Deposition;design;Development;Diabetes Mellitus;Diarrhea;Disease;Dose;Drug Delivery Systems;Dryness;Encapsulated;Epithelium;Evaluation;Fatality rate;Formulation;Generations;Glycoproteins;Goals;Health Personnel;Home;Hospitals;Hypertension;Immune;Immune response;Immunization;Immunize;Immunoglobulin G;Individual;Infection;infection rate;Inhalation;Intramuscular;large scale production;liposomal delivery;liposome vector;Liposomes;low and middle-income countries;Lower respiratory tract structure;Lung;manufacture;manufacturing facility;Marketing;Mass Vaccinations;Mediating;Membrane Fusion;Memory B-Lymphocyte;method development;Modeling;Mucous Membrane;Multiple Organ Failure;Mus;nanoparticle;Nature;neutralizing antibody;novel;oral vaccine;Organ;pandemic disease;particle;Particulate;pathogen;Patients;Play;Pneumonia;Powder dose form;Process;Proteins;public health emergency;Publishing;receptor;Refrigeration;Respiration Disorders;response;RNA vaccine;Role;SARS-CoV-2 infection;scale up;Secretory Immunoglobulin A;Self Administration;Stress;supply chain;Surface;System;T-Lymphocyte;Testing;thermostability;Training;United States;Upper respiratory tract;Vaccination;vaccine delivery;vaccine development;vaccine distribution;vaccine efficacy;Vaccines;viral transmission;Virus;Visit;Work;World Health Organization

PROJECT_TITLE: Design and development of a novel, thermostable, and inhalable dry powder COVID-19 vaccine


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lung;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: RELEVANCE TO PUBLIC HEALTH This project aims to dissect mechanisms how inhalation of particulate matter results in the induction of lipid peroxidation and atherosclerosis, an inflammatory process within the blood vessels that is initiated and propagated by the deposition of lipids and inflammatory cells, which is the main cause for cardiovascular diseases such as heart attacks and strokes responsible for the largest number of deaths in the western world. Air pollution contains both gaseous and particulate components (particulate matter), and it appears that the latter ones are mostly responsible for its cardiovascular toxicity by promoting systemic oxidative stress and proinflammatory effects that result in exacerbation of atherosclerosis. This proposal is designed to determine whether particulate matter-induced cardiometabolic toxicity is mediated by alveolar macrophages and whether enhancement of the macrophage antioxidant defense, provided by the Nrf2/Heme oxygenase 1 anti-oxidant axis would mitigate it, with the ultimate goal of helping to develop in the future, strategies that could allow inhibiting the toxic and harmful effects of air pollutants.

PI_NAMEs: ARAUJO, JESUS ANTONIO (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Ablation;Adipose tissue;air filter;Air Pollutants;Air Pollution;Alveolar;Alveolar Macrophages;Animals;Anti-Inflammatory Agents;Antioxidants;Aorta;Apolipoprotein E;Appearance;Arachidonic Acids;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biological;Birth;Blood;Blood Vessels;Bone Marrow Transplantation;Bronchoalveolar Lavage Fluid;Cardiology;cardiometabolism;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Cells;Cessation of life;Chemistry;Chimera organism;Data;Deposition;design;Development;Diameter;Diesel Exhaust;Drug Metabolic Detoxication;Epidemiology;epidemiology study;experimental study;Exposure to;Fatty Liver;Future;Genes;Goals;Health;Heat shock proteins;Heme Group;heme oxygenase-1;Hydroxyeicosatetraenoic Acids;Inflammatory;Inhalation;Inhalation Exposure;interstitial;Intervention;Isoprostanes;Kinetics;Knockout Mice;Knowledge;Lead;Linoleic Acids;lipid metabolism;Lipid Peroxidation;Lipids;Lipoproteins;Lipoxygenase;Liver;Lung;Macrophage;Macrophage Activation;Mediating;Mediator;member;Metabolic;meter;Morbidity - disease rate;mortality;Mus;Myelogenous;Myocardial Infarction;novel;novel marker;Outcome;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress;particle;particle exposure;Particulate;Particulate Matter;Pathway interactions;Peripheral;PF4 Gene;Phase;Plasma;Prevention approach;preventive intervention;Process;prophylactic;Public Health;rational design;Reactive Oxygen Species;Research;response;Signal Induction;Signal Transduction;Stroke;Syndrome;systemic toxicity;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;transcription factor;Transcriptional Activation;Transgenic Organisms;Translating;Travel;ultrafine particle;Up-Regulation;uptake;Western World

PROJECT_TITLE: Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: Despite the development of novel targeted treatment and immune therapies that have prolonged survival in some patients with non-small cell lung cancer (NSCLC), NSCLC is still the leading cause of cancer-related death in the U.S. We will identify the target proteins of an ADC-specific and two SCC-specific pfeRNAs and decipher the machinimas underlying their interaction, opening a new window of understanding in the sncRNA field and providing new evidence on NSCLC oncogenesis.

PI_NAMEs: MEI, YUPING  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Adenocarcinoma;Antibodies;Automobile Driving;Benign;Binding;Biological;Biological Assay;Biological Markers;Biology;biomarker validation;Biopsy;Biotin;Cancer Etiology;Cells;Cessation of life;Characteristics;Clinical;Clinical Data;Computer software;Cytoplasm;Data;Data Set;deep sequencing;Development;Diagnosis;Disease;Ectopic Expression;Elements;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;Fractionation;Health;Histologic;Human;Immunoprecipitation;Immunotherapy;improved;In Vitro;knock-down;Knowledge;Label;Liquid Chromatography;Lung;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Molecular;mutant;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Nuclear;Oligonucleotides;Oncogenic;Patients;Pattern;Plasma;Play;Prognosis;protein activation;protein complex;protein expression;protein function;Protein Inhibition;Proteins;Publications;Research;RNA-Binding Proteins;Role;Sensitivity and Specificity;Solid;Specific qualifier value;Specificity;Squamous cell carcinoma;Structure of parenchyma of lung;Survival Rate;tandem mass spectrometry;targeted treatment;Tertiary Protein Structure;Testing;Tissues;tumorigenesis;United States

PROJECT_TITLE: Identify the target proteins of one ADC-specific and two SCC-specific pfeRNAs and investigate the mechanisms underlying the pfeRNA-protein interaction.


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Clinical resistance to all front-line antibiotics used to treat methicillin-resistant Staphylococcus aureus (MRSA) has been observed, highlighting the urgent need for new strategies to overcome drug resistance. Previous work by our group has identified tofacitinib analogs as beta-lactam potentiators against MRSA and have identified PurM, SrrB, and PknB as their putative molecular targets. Our current work will demonstrate target engagement and will establish their therapeutic potential in vivo.

PI_NAMEs: PHELPS, GREGORY A (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;ADME Study;Amines;analog;Animal Testing;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;beta-Lactams;Binding;Biochemical;Biological;Biological Assay;Biological Availability;biophysical analysis;Biophysics;Categories;Cell Physiology;Chemicals;Chemistry;Chemosensitization;Clinical;clinical development;Communities;Dangerousness;Daptomycin;Development;Dose;drug discovery;Drug Kinetics;Drug resistance;drug resistant pathogen;efficacy study;experimental study;gene complementation;Genetic Transcription;Gentian Violet;Genus staphylococcus;healthcare burden;high throughput screening;House mice;Human;In Vitro;in vivo;in vivo evaluation;interest;Intravenous;Janus kinase;kinase inhibitor;knockout gene;Lead;Leadership;Libraries;Linezolid;Luciferases;Measures;Mentors;Methicillin;methicillin resistant Staphylococcus aureus;microbial;Microbial Biofilms;Microbiology;Mind;Modernization;Molecular Target;mortality;mouse model;novel;Oral;Oxacillin;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Prevalence;Prevention;Prokaryotic Cells;Property;Proteomics;Public Health;Research;Resistance;Resources;response;Saint Jude Children's Research Hospital;Sepsis;Series;Signal Transduction;Signal Transduction Pathway;skills;small molecule;small molecule libraries;Staphylococcus aureus;Staphylococcus aureus infection;Stomach;System;Systems Development;Techniques;Therapeutic;Training;transcriptomics;Validation;Vancomycin;Virulence;Work;World Health Organization

PROJECT_TITLE: Tofacitinib Analogs as Oxacillin Potentiators against MRSA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Ozone exposure increases pulmonary inflammation and there are currently no available therapeutic strategies to limit the adverse effects of ozone. This application studies how dietary administration of docosahexaenoic acid (DHA), a nutrient that is generally deficient in the western diet, can improve pulmonary inflammation through two distinct mechanisms. Completion of this proposal will set the basis for improved dietary strategies to improve pulmonary outcomes upon ozone exposure.

PI_NAMEs: GOWDY, KYMBERLY MAE (contact);SHAIKH, SAAME R

PROJECT_TERMS: Acute;Adverse effects;air filter;Air Pollution;Alveolar Macrophages;Apoptotic;Area;Biochemical;biophysical model;Biophysics;Cell membrane;Cells;chemokine;Cholesterol;Chronic lung disease;Clinical;Complex;Consumption;criteria air pollutant;cytokine;Data;Diet;dietary;Dietary Administration;Docosahexaenoic acid supplement;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Environmental Pollutants;Exposure to;FPR2 gene;Health;human model;imaging approach;Immunology;improved;In Vitro;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;Inhalation Toxicology;Injury;innovation;Intake;Knockout Mice;Link;lipid mediator;lipidomics;Lung;lung injury;Macrophage;Mediating;Membrane;Membrane Microdomains;methyl-beta-cyclodextrin;Microscopy;Modeling;Morbidity - disease rate;multidisciplinary;Mus;NF-kappa B;novel therapeutic intervention;Nutrient;Nutritional Biochemistry;Omega-3 Fatty Acids;Outcome;Ozone;ozone exposure;Phenotype;Population;Predisposition;prevent;Production;Public Health;Pulmonary Inflammation;quantitative imaging;receptor;Recommendation;recruit;Reporting;Resolution;Role;Signal Transduction;Sorting;Source;Structure;targeted treatment;Testing;Therapeutic;TLR4 gene;western diet

PROJECT_TITLE: Dietary DHA mitigates ozone induced pulmonary inflammation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Cell fate decisions depend on the activity of enhancer elements and their target genes. Elucidating the enhancer-gene pair "code" that establishes early cell type diversity will yield fundamental insights into how cell fates emerge during differentiation and development. This project will deliver an unprecedented dataset of functionally validated enhancer-gene pairs during a key period of mammalian development, germ layer formation, which we anticipate will open new frontiers in stem cell differentiation and cellular therapies.

PI_NAMEs: REGALADO, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Adult;Affect;Architecture;ATAC-seq;Automobile Driving;Bar Codes;Biological Assay;candidate validation;Catalogs;Cell Aggregation;cell fate specification;Cell Line;Cell Therapy;cell type;Cells;Code;combinatorial;CRISPR interference;CRISPR screen;CRISPR/Cas technology;critical period;Data;Data Set;Development;Differentiation Therapy;Dissection;DNA;DNA Sequence;dynamic system;Ectoderm;Elements;Embryo;Embryoid bodies;Embryonic Development;embryonic stem cell;Encyclopedia of DNA Elements;Endoderm;Enhancers;Epigenetic Process;frontier;gastrulation;Gene Expression;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome editing;Germ Layers;Human body;Human Genome;Human Genome Project;Immunofluorescence Immunologic;improved;indexing;Individual;insight;Life;Link;Maps;Measurement;Mesoderm;Methods;Molecular Profiling;Mouse Embryonic Stem Cells;Mus;pluripotency;programs;Proteins;Publishing;Regulatory Element;Research Design;RNA;Sampling;single cell analysis;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;stem cell differentiation;stem cell technology;System;Testing;Tissues;Transcript;transcriptome sequencing;Untranslated RNA;Validation;Whole Organism

PROJECT_TITLE: Optimization of a massively parallel genome editing approach to link regulatory elements to their target genes during mouse germ layer formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Prevention;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE There is nothing more aligned with the NIDA Strategic Plan to protect the public health than detecting signals of emerging drug use trends. This proposal coordinates the data collection efforts from 18 sites and NIDA funded investigators to notify people everywhere of the signals detected. With this information, immediate responses can take place for interventions. The team at UF/NYU and FAU are strong and have the capability to immediately innovate an expanded National Drug Early Warning Network for the public health.

PI_NAMEs: COTTLER, LINDA B. (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: addiction;Algorithms;Annual Reports;Anticonvulsants;Area;Artificial Intelligence;Attention;authority;Bioinformatics;Cities;Cognitive;Collaborations;Communicable Diseases;Communities;Consensus;dashboard;Data;Data Collection;data dashboard;Data Sources;Detection;Development;Diffusion of Innovation;Discipline;Drug usage;Early Diagnosis;Education;Ensure;Epidemiology;epidemiology study;evidence base;Feedback;Florida;Forensic Medicine;Funding;Future;future epidemic;Geography;Hair;Health;innovation;International;Intervention;Location;Machine Learning;Maps;Measures;meetings;Methodology;Methods;Modeling;mortality;National Institute of Drug Abuse;New York;next generation;Notification;novel;Outcome;Overdose;Peer Review;Perception;Persons;Pharmaceutical Preparations;Population Surveillance;prevent epidemics;Prevention strategy;Price;Process;Psychiatry;Public Health;Publications;Qualifying;Quality Control;Reporting;Research;Research Personnel;response;Robotics;Rural;Science;Scientist;Sentinel Surveillance;Signal Transduction;Site;social media;Sociology;Source;Standardization;Strategic Planning;substance use;substance user;suburb;surveillance data;Surveillance Methods;System;Techniques;Testing;theories;Time;Toxicology;Training;trend;U-Series Cooperative Agreements;Universities;Update;virtual;web site;webinar;Work

PROJECT_TITLE: National Drug Early Warning System Coordinating Center


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Whereas Alzheimer's Disease (AD), a progressive neurodegenerative disease, generally manifests in cognitive decline and brain pathology in the form of plaques and tangles, a subset of aged individuals show AD-like pathology without the corresponding cognitive decline. Initial post-mortem analysis of brain tissue from these “resistant” individuals has highlighted changes in the composition of a specific class of non-neuronal cells called astrocytes, suggesting that distributions of these cells may confer protection against AD pathology. This proposal aims to shed light on astrocytes and coordinated changes in their composition with other cells at the molecular level, thus furthering our understanding of the disease, and potentially identifying sets of therapeutic avenues to counter cell type- dysregulation in AD.

PI_NAMEs: MENON, VILAS  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Aging;aging population;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Antibodies;Astrocytes;Autopsy;Brain;Brain Pathology;Brain region;brain tissue;Candidate Disease Gene;candidate identification;Caucasians;cell type;Cells;Clinical;clinical phenotype;Cognitive;cohort;Data;data integration;data modalities;Disease;ethnic diversity;frontal lobe;Gene Expression;Genes;genetic signature;genome-wide;Goals;Human;Image;Immunohistochemistry;Impaired cognition;Indirect Immunofluorescence;Individual;Maps;Mediating;Molecular;Molecular Profiling;multi-ethnic;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;neuropsychiatric symptom;Pathologic;Pathology;Pathway interactions;Predisposition;Proteins;Resistance;Resolution;response;Sampling;single nucleus RNA-sequencing;Spatial Distribution;spatial integration;Stains;System;Systems Biology;tau Proteins;Therapeutic;Tissues;transcriptome;transcriptomics;Work

PROJECT_TITLE: Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Poly ADP ribose polymerase inhibitor (PARPi) have changed treatment paradigms, with greatest clinical benefits in BRCA mutant homologous recombination (HR) deficient ovarian cancer. A critical clinical problem is chemotherapy drugs, including PARPi, are far less effective in BRCA wild-type HR proficient ovarian cancer (e.g. CCNE1 amplification/gain). This proposal will apply an innovative translational research approach to determine the potential benefits of PARPi-epigenetic drug combinations for the treatment of poor prognostic ovarian cancer.

PI_NAMEs: KHABELE, DINEO  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Aftercare;antitumor effect;Back;Biological Assay;Biological Markers;Blood specimen;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Model;carcinogenesis;CCNE1 gene;Cell Line;cell type;Chemicals;chemotherapy;ChIP-seq;Clinic;Clinical;clinical development;Clinical Trials;clinically relevant;Combined Modality Therapy;companion diagnostics;Complement;Data;design;DNA Methyltransferase Inhibitor;Drug Combinations;effective therapy;epigenetic drug;Epigenetic Process;epigenetic therapy;Future;Gene Expression;gene function;gene repression;Genes;Genetic Transcription;genome-wide;Histone Deacetylase Inhibitor;homologous recombination;homologous recombination deficiency;In Vitro;in vivo;inhibitor;inhibitor therapy;innovation;insight;Knowledge;Malignant neoplasm of ovary;Measures;Methods;Molecular;mutant;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase I/II Clinical Trial;Phase I/II Trial;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;pre-clinical;Pre-Clinical Model;Precision Run-On Sequencing;preclinical development;prognostic;Publishing;Regimen;Repression;Resistance;response;response biomarker;Surrogate Markers;Testing;Therapeutic;Toxic effect;transcriptome sequencing;translational approach;Translational Research;tumor;Validation

PROJECT_TITLE: Epigenetic Drug Regimens for Homologous Recombination Proficient Ovarian Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE For the over 15 million epilepsy patients worldwide who do not respond to drugs, successful surgery is a hopeful alternative for seizure freedom, but it can only be achieved through complete resection or disconnection of the epileptogenic zone (EZ), the brain region(s) where seizures originate. Unfortunately, surgical success rates vary between 30%-70% because no clinically validated biological markers of the EZ exist, requiring days to weeks of extensive monitoring by clinicians of many patients with intracranial EEG. The objectives of our proposed computational approaches and experiments are to (i) develop and validate a new EEG marker based on dynamical systems modeling, and (ii) develop a method to guide periodic cortical stimulation to elicit seizures for EZ localization – which, if successful, have the potential to significantly reduce invasive monitoring times, avoiding further risks to patients and reducing costs.

PI_NAMEs: GONZALEZ-MARTINEZ, JORGE ALVARO;SARMA, SRIDEVI V. (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Algorithms;anti-epileptic agents;Biological Markers;Biological Models;Brain;Brain region;Clinical;Consumption;cost;Data;Data Set;Diagnosis;dynamic system;efficacy testing;Electric Stimulation;Electroencephalography;Electrophysiology (science);Epilepsy;Evaluation;Evoked Potentials;Excision;experimental study;Eye;Floor;Freedom;Frequencies;Hemorrhage;Hospitals;Image;in vivo;Individual;Infection;Intractable Epilepsy;Magnetic Resonance Imaging;Measures;Medical;Medical center;Methods;Monitor;Motor;network models;Network-based;Neurologic Deficit;noninvasive diagnosis;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;Periodicals;Pharmaceutical Preparations;Physiologic pulse;Positioning Attribute;Positron-Emission Tomography;Process;Property;randomized, controlled study;response;Rest;Risk;Scalp structure;Seizures;signal processing;Site;Source;Stimulus;success;System;Testing;Time;tool;Universities;Validation;Visual;voltage

PROJECT_TITLE: Establishing novel properties of dynamic systems models to identify epileptogenic networks in patients with drug resistant epilepsy


ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative: Device-related infections are a major complication in orthopaedic medicine resulting in a large economic burden, significant patient morbidity, and are increasingly difficult to treat because as biofilm infections, they are resistant to antibiotics and the host immune system. An emerging strategy to treat other types of antibiotic- and multidrug-resistant infections is to directly target and lyse the bacterial pathogen using IV-administration of bacteriophage (viruses that kill bacteria) or `phage'. As IV phage administration has drawbacks for phage treatment of orthopaedic device-related infections (ODRIs), including the loss of phage during delivery and long-term exposure to the immune system, we propose here an innovative nanotechnology strategy using a biodegradable microsphere delivery system, originally developed to deliver antibiotics, to locally administer lytic phage to treat ODRIs and eventually improve patient outcomes.

PI_NAMEs: AMBROSE, CATHERINE G;KAPLAN, HEIDI B (contact)

PROJECT_TERMS: Age;American Type Culture Collection;Animals;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;bacterial resistance;Bacteriophages;Biodegradable microsphere;biomaterial compatibility;bone;Cell Culture Techniques;Classification;Clinical;Clinical Trials;college;Complication;Cytolysis;Debridement;Devices;Economic Burden;efficacy evaluation;Encapsulated;Ensure;Excision;experimental group;Exposure to;Glycolates;Goals;Human;Immune system;Implant;improved;In Vitro;in vivo;Individual;Infection;innovation;Intramuscular Injections;Intravenous;Investigation;Irrigation;Laboratories;Life;Lytic;manufacture;manufacturing process;Medicine;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Microbial Biofilms;microsphere delivery;Microspheres;Modeling;Morbidity - disease rate;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Nanotechnology;Operative Surgical Procedures;Oral Administration;Orthopedic Surgery;Orthopedics;Osteoblasts;Osteomyelitis;pathogenic bacteria;Patient-Focused Outcomes;Patients;Penetration;Polymethyl Methacrylate;Population;Predisposition;Protocols documentation;Rattus;Regimen;Research;Resistance;resistance mechanism;Site;Staphylococcus aureus;Staphylococcus aureus infection;Surface;System;Testing;Therapeutic;Tissues;Titanium;Treatment Efficacy;Virus

PROJECT_TITLE: Treatment of Multidrug-Resistant Staphylococcus aureus Orthopaedic-Device Related Biofilm Infections with Local Delivery of Lytic Bacteriophage

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LA MARQUE

ORG_NAME: MICROGEN, LLC

PHR: Project Narrative/Public Health Significance This study will test the effectiveness of a group intervention (the MLI) integrated into prenatal care for pregnant Latinas, compared to usual care, that targets reducing psychosocial risks (depressive symptoms, anxiety, stress, and negative coping). We will explore potential effects of the MLI on: a) the maternal hormonal response, and b) infant birth outcomes. We expect the MLI will provide a greatly needed, novel, feasible, and effective nonpharmacological program for this underserved population.

PI_NAMEs: RUIZ, ROBERTA JEANNE (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acculturation;Address;Admission activity;adverse birth outcomes;American;antepartum depression;Anxiety;anxiety reduction;Behavior Therapy;Biological;biopsychosocial;Birth;Birth Weight;Caproates;care providers;Cervical Cerclage;Child;Clinical;Cognitive Therapy;college;Comprehensive Health Care;coping;Corticotropin-Releasing Hormone;Depressed mood;depressive symptoms;design;Diagnosis;Discipline of obstetrics;early pregnancy;effectiveness testing;efficacy evaluation;Estriol;evidence base;flexibility;follow-up;Gestational Age;group intervention;Gynecology;Health;health disparity;Hispanic Women;Hormonal;Hydroxyprogesterone;improved;Infant;innovation;Intervention;intervention participants;Latina;Latina Population;lifestyle intervention;Long-Term Effects;longitudinal analysis;Low Birth Weight Infant;Manuals;Mediating;Mediator;Medical;Mental Depression;Mexican Americans;Mission;Modeling;Mothers;National Institute of Child Health and Human Development;Neurosecretory Systems;novel;Nurse Midwives;Nurse Practitioners;Outcome;Participant;perceived stress;Pharmaceutical Preparations;Pilot Projects;pilot test;Population;Postpartum Depression;Pregnancy;pregnant;premature;Premature Birth;Prenatal care;prenatal health;prevent;problem solving therapy;Progesterone;programs;Provider;psychologic;psychological distress;Psychological Stress;Psychoneuroimmunology;psychosocial;Public Health;Randomized, Controlled Trials;Reporting;Research;response;Risk;Risk Factors;Risk Reduction;screening;Stress;Subgroup;Testing;Time;treatment as usual;treatment group;Underserved Population;United States;Woman;Work

PROJECT_TITLE: Reductions in biopsychosocial risks for pregnant Latinas and their infants: the Mastery Lifestyle Intervention

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: GEOHealth Bangladesh Center for research training main phase grant was jointly awarded to the University of Chicago (UofC) and International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B) in 2015 to strengthen the research capacity of Bangladesh on pressing environmental and occupational health threats. In this renewal phase, we propose to refine and advance the training curricula that were used over the past 5 years to incorporate more materials on utilizing advanced technologies and analytical tools (artificial intelligence/machine learning (AI/ML), image analysis, mobile health (mHealth) data capture/analytics, exposure data science, etc.) for analyzing environmental exposure and health effects data with the existing materials, all of which are highly relevant to the linked U01 application’s research. Moreover, we propose to leverage the newly launched Masters of Public Health (MPH) and Masters of Science in Precision Health (MSPH) degree programs at UofC as a long-term training option, along with the 1-year post-doctoral and 12-week training at UofC, and shorter-term in-country short-courses (2 weeks) and workshops (1-2 days) in Bangladesh.

PI_NAMEs: AHSAN, HABIBUL  (contact);RAQIB, RUBHANA

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Acute;Address;analytical tool;Artificial Intelligence;Award;Bangladesh;career;career development;Chicago;Collaborations;Country;Custom;Data Science;Degree program;design;diarrheal disease;Educational Curriculum;Educational workshop;Ensure;Environmental Health;Evaluation;Fellowship;Foundations;Funding;global environment;Goals;Grant;health data;Image Analysis;Influentials;Institution;international center;Knowledge;Link;Machine Learning;Master of Science;Medical;Mentors;mHealth;Modernization;Monitor;Occupational Health;Participant;Peer Review;Phase;post-doctoral training;Postdoctoral Fellow;Productivity;programs;Publications;Reporting;Research;Research Methodology;Research Personnel;satisfaction;Students;success;System;Techniques;Technology;tool;Training;Training Activity;Training Programs;Universities;Work

PROJECT_TITLE: 2/2 Bangladesh Center for Global Environmental and Occupational Health-US

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Project Narrative The proposed research builds on our previous work in the region and is designed to enhance capacity to carry out research and provide data useful to policy makers in our focus area of building capacity in Ambient Air Pollution (AAP) research in Peru and study the association between AAP and cardiovascular, respiratory, and neurodegenerative health outcomes, including COVID-19 and Alzheimer’s where the association with AAP is not well established. Emory University will submit the linked research training grant application, which is titled “2/2 – Regional Geohealth Hub centered in Peru –US.”

PI_NAMEs: CHECKLEY, WILLIAM ;GONZALES, GUSTAVO F;HARTINGER, STELLA MARIA (contact);STEENLAND, NELSON K

PROJECT_TERMS: Address;Adult;Age;Air Pollution;Alzheimer's Disease;ambient air pollution;Applications Grants;Area;Asthma;atmospheric modeling;Automobile Driving;burden of illness;Cardiovascular Diseases;Cardiovascular system;Case Fatality Rates;Cessation of life;Charge;Chronic Obstructive Pulmonary Disease;Cities;Clinic;Cognition;Cognitive deficits;cognitive function;cognitive interview;Cohort Studies;Collaborations;cost effective;Country;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 risk;Data;Databases;Death Rate;Dementia;design;Disease;effectiveness evaluation;Emergency department visit;Environmental Risk Factor;Exposure to;fine particles;Frontotemporal Dementia;General Population;Government;greenhouse gases;Guidelines;Health;high risk;Hospitalization;Hospitals;improved;Incidence;Interdisciplinary Study;Interruption;Intervention;Latin America;Life Cycle Stages;Life Expectancy;Link;Long-Term Effects;low and middle-income countries;Modeling;Monitor;Morbidity - disease rate;mortality;Neighborhoods;Nerve Degeneration;Neurology;Nitrogen Dioxide;novel;Outcome;Paris, France;Peru;Peruvian;Pneumonia;Policies;Policy Maker;Population;Premature Mortality;Publishing;Questionnaires;Recommendation;Recording of previous events;Regulation;remote sensing;Research;Research Training;residence;Resolution;respiratory;Respiratory Disease;response;Series;severe COVID-19;sex;Source;supplemental oxygen;Telephone Interviews;Time;traffic-related air pollution;Universities;Update;Vaccination;Work

PROJECT_TITLE: 1/2 - Regional GEOhealth Hub Centered In Peru-Peru


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Acute liver failure (ALF) is associated with a dysfunctional immune response, but the reason for this is unclear. My proposal will investigate if senescent hepatocytes reprogram infiltrating immune cells interfering with their capacity to promote liver regeneration after injury. This work will elucidate the role of hepatocyte senescence in influencing the liver microenvironment to facilitate ALF and will support the identification of novel therapeutic approaches to address this unmet clinical need.

PI_NAMEs: UMBAUGH, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;Acute Liver Failure;Address;Alanine Transaminase;Anti-Inflammatory Agents;Automobile Driving;Blood Coagulation Disorders;Cell Aging;Cell Cycle Arrest;Cell Physiology;Cell Reprogramming;Cells;Cellular Stress;Cessation of life;chromatin immunoprecipitation;Circulation;Clinic;Clinical;Communication;cytokine;Data;Dependovirus;design;Development;Dose;Drug Metabolic Detoxication;Equilibrium;Event;Exhibits;experimental study;Female;Flow Cytometry;Functional disorder;functional status;gain of function;Genes;Genetic;Genetic Transcription;Hepatic Encephalopathy;Hepatocyte;Human;Icterus;Immune;immune cell infiltrate;Immune response;immunological status;improved;in silico;In Vitro;in vivo;Inflammatory;Inflammatory Response;Injury;injury recovery;Innate Immune Response;insight;Lead;Literature;Liver;liver injury;Liver Regeneration;loss of function;Macrophage;male;Mediating;Mediator;Molecular;mouse model;Multiple Organ Failure;Mus;N-acetyl-4-benzoquinoneimine;Necrosis;neutrophil;novel strategies;novel therapeutic intervention;overexpression;Pathway interactions;Patients;Phenotype;Plasma;Play;Population;Production;programs;Recovery;Recovery Support;Resolution;Role;senescence;senescent cell;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Sorting;Stress;Testing;tissue injury;tissue repair;Tissues;Transcription Coactivator;Transcriptional Activation;United States;Work

PROJECT_TITLE: Senescent hepatocytes mediate reprogramming of immune cells in acute liver failure


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Dilated cardiomyopathy (DCM) is one of the most common hereditary heart diseases and cardiac fibrosis is a common hallmark. In this study, we will investigate the mechanism of cardiac fibrosis by elucidating cellular crosstalks between cardiac fibroblasts (CFs) and cardiomyocytes (CMs). Coupled with engineered heart tissue (EHT), single cell RNA sequencing (scRNA-seq), state-of-the-art CRISPR/dCas9i and CRISPR/dCas9a genome screening technologies, and DCM mouse model, we aim to uncover the underlying mechanism for cardiac fibrosis development and identify potential therapy to inhibit this process.

PI_NAMEs: WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 3-Dimensional;Address;Bioinformatics;Biological Process;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;connectin;coronary fibrosis;Coupled;CRISPR screen;CRISPR/Cas technology;Development;differentiation protocol;Dilated Cardiomyopathy;Disease;disease model;druggable target;effective therapy;Electrophysiology (science);Endothelial Cells;familial dilated cardiomyopathy;Family;Fibroblasts;Fibrosis;Functional disorder;Future;Gene Activation;Gene Mutation;Gene Silencing;Genes;Genome;Grant;Heart;Heart Diseases;heart function;high throughput screening;human induced pluripotent stem cells;induced pluripotent stem cell;Inherited;interstitial;Knowledge;Lamin Type A;Maps;mechanical properties;Mediating;Medicine;Modeling;monolayer;mouse model;multidisciplinary;Mutation;Myocardial dysfunction;Myofibroblast;novel;Nuclear;Optics;Organ;Paper;Pathogenesis;Pathway interactions;Patients;Pattern;Point Mutation;Process;Proteins;Publications;Qi;Role;screening;single-cell RNA sequencing;Stromal Cells;System;Technology;Testing;Tissue Engineering;Tissues;transcriptome;transcriptomics;Transforming Growth Factor beta;Troponin T;Tungsten;Wing

PROJECT_TITLE: Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering;Genetics;Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Genetic and molecular approaches in the fruit fly, Drosophila melanogaster, will be used to dissect the complex problem of how neurons obtain their unique identities. By focusing on a set of motor neurons used for walking in the adult fly, the goal is to gain insights into how neurons achieve their exquisite synaptic specificities and dendritic architectures, and how perturbations to these morphologies affects coordinated leg movements, such as walking by adult flies.

PI_NAMEs: MANN, RICHARD S (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Affect;Afferent Neurons;appendage;Architecture;Area;Astrocytes;ATAC-seq;Axon;Binding;Cells;Cellular Morphology;Central Nervous System;Chest;Chromatin;Code;combinatorial;Complex;Data;Dendrites;Development;Drosophila genus;Drosophila melanogaster;Embryonic Development;Equilibrium;experience;Family;Family member;fly;Funding;Gene Expression;Gene Family;Genes;Genetic;genome-wide;Goals;Image;in vivo;Individual;insight;Instruction;Interneurons;Knowledge;Larva;Leg;Locomotion;Logic;Maps;member;Methods;Modeling;Molecular;Molecular Profiling;Morphology;Motor;motor control;motor neuron development;Motor Neurons;Movement;Muscle;Muscle Fibers;Names;neural;neuroblast;Neuroglia;Neurons;Neuropil;Play;Postembryonic;postmitotic;programs;Recording of previous events;Resolution;Role;Series;Side;Specific qualifier value;Specificity;Stereotyping;Synapses;synaptogenesis;System;Testing;Time;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;Walking;whole genome

PROJECT_TITLE: Development and Function of an Adult Locomotion Circuit in Drosophila

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Glioblastoma is a universally fatal brain tumor that is resistant to both the standard of care and novel therapies including immunotherapy, which have been approved by the FDA for more than 15 indications, such as melanoma and lung cancer. Based on our preliminary studies and the published literature, we hypothesize that abnormal vasculature in brain tumors enhances immunosuppression resulting in resistance to the immunotherapy. Our findings will provide unprecedented insights into the mechanisms of resistance to immunotherapy in glioblastoma, and a novel strategy to overcome this resistance while alleviating putative adverse effects, which will inform the design of clinical trials of glioma patients.

PI_NAMEs: FUKUMURA, DAI  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Abbreviations;Adverse effects;Adverse event;Angiopoietin-2;anti-PD-1;anti-PD1 therapy;Antibodies;antibody test;antibody-dependent cell cytotoxicity;Antigen-Presenting Cells;Autoimmune;bevacizumab;Bispecific Antibodies;Blood Vessels;Brain Neoplasms;cancer cell;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cell Communication;cell killing;Cells;Cervical;chemoradiation;Clinical Research;Clinical Trials Design;Combined Modality Therapy;comorbidity;Complex;cytokine;Cytolysis;Cytotoxic T-Lymphocytes;Data;Development;dosage;Drug Delivery Systems;Edema;Endothelial Cells;Exclusion;Failure;FDA approved;Glioblastoma;Glioma;Hemorrhage;Hypoxia;Imaging Techniques;Immune;immune checkpoint blockers;Immune Evasion;Immunoglobulin G;Immunohistochemistry;Immunologic Surveillance;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;in vivo;in vivo imaging;Infiltration;Inflammation;Inflammatory Response;insight;intravital imaging;Literature;Long-Term Survivors;lymph nodes;Lymphocyte Function;lymphocyte trafficking;Lymphocytic Infiltrate;Macrophage;Malignant neoplasm of lung;Measures;Mediating;Melanoma;Memory;Mus;Myeloid Cells;neoantigens;neoplastic cell;novel strategies;novel therapeutics;Operative Surgical Procedures;Organ;Patients;Perfusion;Peripheral;Phase III Clinical Trials;Phenotype;Pilot Projects;preclinical study;Proliferating;Publishing;Quality of life;Reaction;receptor;Regulatory T-Lymphocyte;repaired;Resistance;resistance mechanism;response;Risk;Spleen;standard of care;Surgical Models;T-Lymphocyte;Testing;Toxic effect;trafficking;Treatment Efficacy;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Up-Regulation;vascular abnormality;Vascular Endothelial Growth Factors

PROJECT_TITLE: Reprogramming the Tumor Microenvironment to Improve Immunotherapy of Glioblastoma by Co-Targeting VEGF and Ang2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Mucopolysaccharidoses (MPS);Orphan Drug;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE Enzymopathies are diseases caused by deficiencies in enzyme function, including genetic deficiency or defects in specific enzymes. Current methods for the treatment of patient’s enzymopathies are insufficient and rely on potentially life-threatening bone marrow transplant or life long enzyme replacement therapy costing upwards of hundreds of thousands of dollars annually. However, it is possible that a patients blood cells, specifically B cells, can be non-invasively isolated, engineered to express the normal functioning enzyme, and subsequently transplanted back into the patient to provide a life long cure for some forms of enzyme deficiencies.

PI_NAMEs: MORIARITY, BRANDEN S (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affect;Animals;Antibodies;Antibody-Producing Cells;Antigens;Automobile Driving;autosome;B cell therapy;B-Lymphocytes;Back;biological research;Blood Cells;Bone Marrow Transplantation;cancer immunotherapy;Cardiopulmonary;CD34 gene;Cell Line;Cell model;Cell Therapy;Cell Transplantation;cell type;Cells;cellular engineering;Cessation of life;Complementary DNA;Cornea;cost;CRISPR/Cas technology;Defect;Development;Disease;disease model;DNA cassette;Effectiveness;Emu species;Engineering;Engraftment;Enhancers;enzyme deficiency;enzyme replacement therapy;Enzymes;Excretory function;experimental study;expression vector;Future;GAG Gene;gene correction;Gene Delivery;gene editing technology;Gene Expression;gene therapy;gene-editing approach;Genes;Genetic;Genetic Diseases;Genetic Transcription;genome editing;Genome engineering;Glycosaminoglycans;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hepatosplenomegaly;Human;Human Engineering;Immunization;immunodeficiency;Immunosuppression;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;insight;integration site;Knock-in;Knock-out;L-Iduronidase;Life;Link;Lymphocyte;Lysosomal Storage Diseases;Medical;Memory B-Lymphocyte;Metabolic;Methods;model organism;Modeling;Morbidity - disease rate;mouse model;Mucopolysaccharidosis I;Mucopolysaccharidosis I H;Mus;National Institute of Allergy and Infectious Disease;Neurologic;novel therapeutics;Obstruction;overexpression;Pathology;Patients;Phycoerythrin;Physicians;Plasma Cells;Pre-Clinical Model;Preclinical Testing;preconditioning;Process;Production;promoter;Proteins;public health relevance;Reagent;Recombinant adeno-associated virus (rAAV);Regimen;Research Personnel;Risk;Serotyping;Signal Transduction;Site;skeletal dysplasia;Specificity;success;System;Systemic disease;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;therapeutic transgene;transgene expression;Transplantation;treatment group;Urine;Work

PROJECT_TITLE: Engineered B Cells as a Universal Platform for the Treatment of Enzymopathies

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed research training builds on our previous work in the region and is designed to enhance capacity to carry out research and provide data useful to policy makers. Our partners at the Universidad Peruana Cayetano Heredia (UCPH) in Lima will submit the linked research application, which is titled ‘1/2 – Regional GEOHealth Hub centered in Peru - Peru’, with projects in the area of air pollution and health outcomes. Our training activities are directly relevant to the research projects and will provide research training opportunities to strengthen the capacity of Peru and neighboring countries to conduct environmental and occupational health research.

PI_NAMEs: CHECKLEY, WILLIAM ;GONZALES, GUSTAVO F;HARTINGER, STELLA MARIA;STEENLAND, NELSON K (contact)

PROJECT_TERMS: Air Pollution;Alzheimer's Disease;Bolivia;Chile;Clinic;Collaborations;COVID-19;Disease;Doctor of Philosophy;Ecuador;Educational Status;Electronic Mail;Environmental Health;Faculty;Food Safety;Frontotemporal Dementia;Funding;Goals;Government Agencies;Grant;Health;hydrology;Letters;Link;meetings;Mentors;Meteorology;Neurology;Peru;Peruvian;Positioning Attribute;programs;Publications;Research;Research Activity;Research Assistant;Research Personnel;Research Project Grants;Research Proposals;Research Training;responsible research conduct;Services;Short-Term Course;skills;South American;Students;Training;Training Activity;training opportunity;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: 2/2 – Regional GEOHealth Hub Centered in Peru-U.S.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Age-related changes in memory for everyday events are a major source of concern for older adults. They have a substantial impact on the economy because they affect elders' ability to live independently and perform tasks of daily living. This project will address fundamental questions about age and dementia-related cognitive differences. It uses tasks that parallel situations people encounter in daily life, which will be of value in translating the findings from the lab to the clinic.

PI_NAMEs: ZACKS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Affect;Age;age effect;age related changes;Aging;Alzheimer's Disease;Anatomy;Attention;attentional control;Basic Science;behavior test;Behavior Therapy;Behavioral;Biological;brain dysfunction;brain metabolism;Cereals;Child;Cities;Clinic;Clinical;clinical application;Clinical Trials;Cognitive;Computer Models;demented;Dementia;effective intervention;Elderly;Elements;Environment;Epidemiology;Event;experience;experimental study;Failure;Family;Goals;healthy aging;Human;Impairment;improved;Individual;innovation;insight;Intervention;Joints;Laboratories;Laboratory Finding;Life;Measures;Medial;medial temporal lobe;member;Memory;memory encoding;memory retrieval;metabolic imaging;Methods;movie;Nervous System;neural;neuroimaging;Neurologic;neuropathology;neurophysiology;novel;older adult;Older Population;Organ;Paper;Parietal Lobe;Participant;Pattern;Perception;Persons;Positioning Attribute;Positron-Emission Tomography;psychologic;remediation;Reporting;Resolution;Sampling;scaffold;Sensory;Source;Stream;Structure;System;Testing;Time;Translating;translational goal;young adult

PROJECT_TITLE: IMPROVING EVERYDAY MEMORY IN HEALTHY AGING AND EARLY ALZHEIMER'S DISEASE

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Defective skin barrier function is a hallmark of diseases known as ichthyoses. In this grant, we will explore how the hair follicle is disrupted in the most severe form of ichthyosis, known as harlequin ichthyosis (HI). In doing so, we will also learn more about the basic physiology and function of the hair follicle.

PI_NAMEs: WONG, SUNNY Y (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acne;Affect;Anatomy;behavior influence;Carrier Proteins;Cell Death;Cell Differentiation process;Cell membrane;Cell Physiology;Cells;Cytoplasmic Granules;Defect;Disease;Enterobacteria phage P1 Cre recombinase;Environment;Epidermis;extracellular;Gene Expression;Gene Expression Profile;Grant;Hair;Hair follicle structure;Harlequin Ichthyosis;Hidradenitis Suppurativa;Homeostasis;Hyperplasia;Ichthyoses;Immunocompetent;In Vitro;insight;keratinocyte;keratinocyte differentiation;Keratosis;Knowledge;Learning;Link;Lipids;Mediating;member;molecular domain;mouse model;Mus;Mutant Strains Mice;Mutate;novel;novel therapeutics;Organelles;Outcome;Patients;Peptide Hydrolases;Phenotype;Physiology;Play;Process;Protein Family;Proteins;response;Role;Sebum;Signal Transduction;Site;Skin;skin barrier;skin disorder;stem cell population;Stratum corneum;Structure;Surface;Testing;Time;tool;Work;wound

PROJECT_TITLE: Exploring hair follicle-associated functions in normal and ichthyotic skin

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Cells frequently face adverse conditions such as toxic substances or a lack of nutrients, and they respond by altering protein synthesis and the expression of their genes in order to ensure their survival. The research in this proposal will reveal how this occurs by studying the regulation of the protein synthesis machinery in response to cellular stresses. Misregulation of these cellular processes is common in both cancer and aging, so studying their mechanisms will provide a foundation for designing future treatments as well as broadening our knowledge of the fundamentals of cell biology.

PI_NAMEs: BOLGER, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Aging;Binding Proteins;Biochemistry;biological adaptation to stress;Biological Assay;Biology;cancer cell;cell growth;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Stress;Childhood Malignant Brain Tumor;Classification;Cognitive;Complement;Complex;Cytoplasm;Defect;design;developmental disease;Disease;Dissociation;Ensure;Environment;Enzymes;Eukaryota;extracellular;Face;Family;Foundations;Fractionation;Future;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;Growth;HIV;Homo;Homologous Gene;Human;Immunoprecipitation;In Vitro;insight;Investigation;Knowledge;Life;Link;live cell microscopy;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Medulloblastoma;Messenger RNA;Methods;Modeling;molecular pathology;mutant;Mutation;Nutrient;nutrient deprivation;Organism;Oxidative Stress;Pathology;Pathway interactions;Play;Poison;Proliferating;Protein Biosynthesis;protein complex;Proteins;Regulation;Reporter;Research;Resources;response;ribosome profiling;Ribosomes;RNA;RNA Helicase;RNA-Binding Proteins;Role;scaffold;sensor;Signal Transduction;Sirolimus;Site;Sorting;Specificity;Stress;stress granule;Structure;T-Cell Lymphoma;Techniques;Testing;Transcript;translation factor;Translation Initiation;translational impact;Translational Regulation;Translational Repression;Translations;tumor progression;Viral Cancer;Virus;Virus Diseases;Work

PROJECT_TITLE: Regulation of the Translational Response to Cellular Stress

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative Early detection of young people at clinical high risk for psychosis offers a critical opportunity for early intervention to improve the course of illness, and perhaps even prevent onset entirely. Current interview-based methods for psychosis risk detection lack specificity, and are only available in a handful of research centers in the United States. The proposed study aims to improve accessibility and broaden impact of high risk screening by testing brief computerized measures, ultimately able to be administered on the internet, and to improve prediction by focusing on tasks specific to underlying mechanisms driving emerging psychotic symptoms.

PI_NAMEs: ELLMAN, LAUREN M (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;American;Attenuated;Automobile Driving;Behavioral;Biological Markers;Clinical;clinical high risk for psychosis;clinical practice;cognitive testing;Collaborations;computerized;Computing Methodologies;design;Detection;Deterioration;Diagnosis;Dimensions;Early Diagnosis;Early identification;Early Intervention;follow-up;Foundations;Frequencies;functional decline;Functional disorder;functional outcomes;Generations;Goals;help-seeking behavior;high risk;high risk population;Human Resources;improved;Individual;Internet;Intervention Trial;Interview;Joints;Link;Longitudinal Studies;Machine Learning;machine learning classification;machine learning method;Measures;Methods;Modeling;neural;Neurobiology;new therapeutic target;next generation;online delivery;Outcome;Participant;Patient Self-Report;Performance;Persons;Population;Predictive Value;prevent;preventive intervention;Primary Prevention;Psychopathology;Psychoses;psychosis risk;psychotic symptoms;Public Health;Publishing;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Sample Size;screening;Secondary Prevention;Severities;Site;social;Specificity;Symptoms;System;Techniques;Test Result;Testing;Training;trait;Translating;United States;Work;Youth

PROJECT_TITLE: CAPER: Computerized Assessment of Psychosis Risk


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE During bacterial infection, the immune system senses both components of the bacteria (known as PAMPS) and perturbation of cellular function by virulence factors of pathogenic bacteria, and this sensing can trigger inflammation. Our results show that manipulation of the endoplasmic reticulum during infection with the bacterial pathogen Brucella abortus triggers inflammatory responses involving two innate immune receptors, NOD1 and NOD2. This application proposes to determine how this pathway is activated during bacterial infection and how endoplasmic reticulum stress can lead to survival or death of infected cells, a process that is central to the development of many inflammatory diseases.

PI_NAMEs: TSOLIS, RENEE M (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: abortion;Agonist;Bacteria;Bacterial Infections;Brucella abortus;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Chlamydia muridarum;Complex;Cytokine Signaling;Cytosol;detection platform;Development;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Event;fetal;Fetal Death;Goals;Immune response;Immune signaling;Immune system;immunogenic cell death;Immunologic Receptors;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;innate immune sensing;Innate Immune System;innovation;Insulin-Dependent Diabetes Mellitus;Link;Macrophage;Mediating;Microbe;microbial;microbial products;Modeling;Molecular;Mononuclear;Natural Immunity;neuroinflammation;novel;Organism;Outcome;pathogen;Pathogen detection;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Pattern;Pattern Recognition;Pattern recognition receptor;Phagocytes;Placenta;placental trophoblasts;Process;Proteins;Research;response;Secretory Cell;Signal Pathway;Signal Transduction;Site;Structure;System;Testing;Tissues;Toll-like receptors;TRAF2 gene;Type IV Secretion System Pathway;Virulence Factors;virus host interaction;Work

PROJECT_TITLE: Innate immune sensing of ER stress during bacterial infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The main aim of this study is to reduce the time and number of tests needed to accurately detect worsening of glaucoma by 1) correcting visual field and optical coherence tomography tests for errors and 2) accurately predicting future disease worsening based on baseline visit clinical, functional and structural data. This research will impact public health by identifying high risk patients earlier so that they can be appropriately managed to prevent vision loss and also by reducing unnecessary testing which places a significant burden on the healthcare system and patients.

PI_NAMEs: YOHANNAN, JITHIN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Accounting;Affect;Area;Bayesian Analysis;Blindness;Calendar;Clinical;Clinical Data;clinical decision-making;compare effectiveness;convolutional neural network;Coupled;Data;Data Science;Data Set;deep learning;deep learning model;demographics;Detection;Diagnostic tests;Disease;Educational workshop;Effectiveness;Ethics;Eye;field study;Future;generative adversarial network;Glaucoma;Goals;Healthcare;Healthcare Systems;high risk;Image;improved;Knowledge;Learning;longitudinal database;Machine Learning;machine learning method;machine learning model;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;model design;Modeling;Monitor;multilevel analysis;neural network architecture;Optical Coherence Tomography;Outcome;Papillary;Patients;Pattern;Performance;Physiologic Intraocular Pressure;Population;predictive modeling;preservation;prevent;programs;Public Health;Pythons;Research;Research Activity;Research Personnel;Research Proposals;Resource Allocation;Resources;responsible research conduct;retinal nerve fiber layer;Risk;risk prediction;Signal Transduction;skills;Stream;Structure;Techniques;Testing;Thick;Time;tool;Training;Visit;Visual Acuity;Visual Fields;visual optics;wasting;Work

PROJECT_TITLE: A Comprehensive Strategy to Detect Glaucoma Worsening Earlier and With Fewer Tests


NIH_SPENDING_CATS: Nutrition

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Lipid Droplets are specialized transient organelles that serve as reservoirs of neutral lipids that can be tapped for energy or to resupply membranes with lipids. Failure to store or use lipids efficiently is the hallmark of metabolic diseases. The proposed research will elucidate the molecular mechanisms that lipid droplet proteins use to regulate lipid metabolism, as well as how alterations in these processes impact cellular energy homeostasis. Ultimately, understanding the molecular control of lipid storage and catabolism will be paramount to gain new insights into lipid storage diseases that will form a considerable healthcare burden in the near future.

PI_NAMEs: KAST, DAVID J (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Actins;Address;arm;Atherosclerosis;Binding;Biochemical;Biogenesis;Capsid Proteins;Catabolism;Cells;Cholesterol Esters;Complex;constriction;Consumption;Coupled;Cytoskeleton;Data;dietary;dietary excess;Dietary Fatty Acid;Disease;Docking;Energy Supply;Exercise;Failure;Fatty acid glycerol esters;Future;Goals;Growth;GTP Binding;Guanine Nucleotides;Guanosine Triphosphate Phosphohydrolases;healthcare burden;Homeostasis;Individual;insight;Insulin Resistance;Intake;lipid metabolism;Lipids;Lipodystrophy;mechanical force;Mediating;Membrane;membrane reconstitution;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Molecular;Mutation;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;Nucleotides;Obesity;Organelles;Organism;overexpression;Pathogenesis;Play;Process;Property;Proteins;Public Health;recruit;Regulation;Research;response;Role;Starvation;structural biology;Surface;Swelling;System;Tissues;Triglycerides;United States

PROJECT_TITLE: Regulation of Lipid Droplet Biogenesis and Lipophagy

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Nutrition;Obesity;Opioids;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE The use of anti-obesity medication (AOM) is recommended when conservative methods fail to achieve and maintain sufficient weight loss. Yet even with the use of AOM, there is a wide range of inter-individual weight loss suggesting that there are “responders” and “non-responders.” The purpose of this study is to determine if genetic biomarkers can be used to better predict the weight loss response to combination therapy with naltrexone/bupropion, an FDA-approved AOM, and thus, open up the field of pharmacogenetics to obesity treatment.

PI_NAMEs: KORNER, JUDITH  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Adult;Affect;Alleles;Ankyrin Repeat;antagonist;Behavior Therapy;behavioral phenotyping;Binding;Biological Markers;Body mass index;Body Weight;Body Weight decreased;Brain;Bupropion;Clinical;Clinical Trials;clinically significant;Combined Modality Therapy;comorbidity;cost;Counseling;density;Desire for food;Diet;Diet therapy;Dopamine;Dopamine D2 Receptor;DRD2 gene;drug response prediction;Eating;Energy Metabolism;Enrollment;Esthesia;Etiology;Exposure to;fat mass and obesity-associated protein;FDA approved;Genes;Genetic;Genetic Markers;Genetic Polymorphism;genetic variant;Genetic Variation;Genotype;Goals;Guidelines;Heritability;Heterogeneity;improved;Individual;Individual Differences;individual patient;individual response;Knowledge;Learning;Measures;Medicine;Metabolism;Methods;Minor;Naltrexone;Neurons;Norepinephrine;Obesity;obesity treatment;Opioid;Opioid Receptor;Other Genetics;Outcome;Participant;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenetics;Pharmacotherapy;Phase;Phosphotransferases;Physical activity;Pilot Projects;Population;prevent;primary endpoint;Pro-Opiomelanocortin;Prolactin;prospective;Proteins;Questionnaires;Recommendation;responders and non-responders;response;reuptake;Rewards;risk variant;Serum;side effect;Signal Transduction;Testing;Time;Weight;weight maintenance

PROJECT_TITLE: Association of genetic variation near the dopamine D2 receptor gene and other polymorphisms that modulate dopaminergic and opioid signaling on the weight loss response to naltrexone/bupropion

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative This project will address how the composition of the heart influences the trajectory of heart failure. In addition, it will elucidate new concepts relating metabolism to inflammation.

PI_NAMEs: JONES, STEVEN P (contact)

PROJECT_TERMS: Abate;Acute;Anabolism;Attention;Binding;Biomechanics;Cardiac;Cardiac Myocytes;Catabolism;CD44 Antigens;cell type;Cells;Chronic;Chronic Phase;Cicatrix;Collagen;Collagen Fibril;Complex;Congestive Heart Failure;Coupled;Data;Dependence;Deposition;Disease;Embryo;Enzymes;Event;Extracellular Matrix;Family;Fibroblasts;Fibrosis;gain of function;Glucose;glucose metabolism;Glycolysis;HAS2 gene;Heart;Heart failure;Hyaluronan;hyaluronan synthase 1;Hyaluronidase;Impairment;Inflammation;Inflammatory;insight;Investigation;Knowledge;Leukocytes;loss of function;Macrophage;Matrix Metalloproteinases;Mediating;Mesenchymal;Metabolic;Metabolism;metabolomics;migration;Mus;Myeloid Cells;Myocardial Infarction;Outcome;Pathologic;Pathology;Pathway interactions;Phase;Population;Process;Production;Proliferating;Proxy;Regulation;response to injury;Role;Shapes;stable isotope;Testing;Tissues;Ventricular Function;Ventricular Remodeling;wound healing

PROJECT_TITLE: Extracellular Matrix Dynamics During Remodeling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Fibromyalgia;Neurosciences;Pain Research;Physical Activity;Prevention;Rheumatoid Arthritis;Sleep Research

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Musculoskeletal pain is the leading cause of disability in the world, and the number one reason patients with arthritis visit healthcare providers. The proposed research will provide quality data on the association between sleep-wake patterns, parasympathetic activity, central nervous system regulatory pathways, and pain in patients with early rheumatoid arthritis. The proposed research is relevant to the NIH’s mission because it will enable the applicant to continue and expand her patient-oriented research training program, thereby fostering the development, maintenance, and renewal of trained investigators, including, but not limited to, those with expertise in tackling the unmet need of treating and preventing chronic pain in patients with arthritis.

PI_NAMEs: LEE, YVONNE CLAIRE (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Accelerometer;Acoustics;Acute;Anesthesiology;Area;Arthritis;Autonomic Dysfunction;Behavioral Sciences;Biosensor;Brain imaging;career;Central Nervous System;central pain;Child;chronic pain;circadian;clinical center;Clinical Research;Cognitive Therapy;cohort;Collaborations;cost;Data;Data Collection;Data Set;Development;diaries;disability;Enrollment;fibromyalgia patients;Fostering;Frequencies;Funding;Future;Health Care Visit;Health Personnel;Heart;heart rate variability;immune modulating agents;Immunosuppressive Agents;improved;Individual;Inflammation;Inflammatory Arthritis;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Intervention Studies;investigator training;joint injury;Kinesiology;Link;Literature;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Mediating;medical schools;Medicine;Mentors;Methodology;Mission;Musculoskeletal Pain;neural;neurobiological mechanism;Neurobiology;neuroimaging;Neurosciences;next generation;non-opioid analgesic;novel;Operative Surgical Procedures;Pain;Pain intensity;pain sensitivity;Parents;Participant;Pathogenesis;Pathway interactions;patient oriented research;Patient Outcomes Assessments;Patient Recruitments;Patient Self-Report;Patients;Pattern;Peripheral;Phenotype;Physical activity;Play;Polysomnography;Postdoctoral Fellow;pre-doctoral;prevent;Process;Productivity;professor;programs;prospective;Recording of previous events;Regulation;Regulatory Pathway;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rest;Rheumatism;Rheumatoid Arthritis;Rheumatology;Scientist;sedentary lifestyle;Sensory;Site;skills;Sleep;sleep abnormalities;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleeplessness;Societies;Subgroup;Symptoms;Testing;Therapeutic;Time;Training;training opportunity;Training Programs;United States National Institutes of Health;Universities;Work;Wrist

PROJECT_TITLE: Mentored Patient-Oriented Research of Novel Mechanisms Linking Pain, Sleep-Wake Patterns, and Autonomic Activity in Rheumatic Diseases

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative The NIMH Repository and Genomics Resource (NRGR) provides research resources that will enable scientists to identify the genetic causes of mental disorders. Understanding these genetic causes will likely result in new diagnostic and therapeutic approaches.

PI_NAMEs: BRZUSTOWICZ, LINDA M;KNOWLES, JAMES A (contact);TISCHFIELD, JAY ARNOLD

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accreditation;adult stem cell;American;Authorization documentation;Automation;Award;base;biobank;Biocompatible Materials;Biological Process;Biological Products;Biological Sciences;bioprocess;Biotechnology;Blood;Budgets;California;Capital;Cell Line;Clinical;Clinical Data;clinical data repository;clinical diagnostics;Clinical Distribution;clinical research site;cohort;Collaborations;Collection;college;Communities;Complementary DNA;complex data;Consent;cost;cost effective;Cryopreservation;Data;data archive;Data Collection;Data Coordinating Center;data curation;data dictionary;data dissemination;data harmonization;data integration;data management;Data Set;data sharing;Data Storage and Retrieval;data submission;Databases;Deposition;Derivation procedure;design;Development;Diagnostic;DNA;Drug Industry;Ensure;Epigenetic Process;Etiology;exome;experience;Fee-for-Service Plans;flexibility;Florida;Funding;Gene Expression;Genetic;Genetic study;genome editing;genome resource;genome-wide;genomic data;Genomics;Goals;Home;improved;Individual;induced pluripotent stem cell;Informed Consent;Infrastructure;innovation;Investments;Licensing;Link;Lymphocyte;Maintenance;Manuals;Maps;Measures;meetings;Mental disorders;Methodology;Monitor;National Institute of Mental Health;New Jersey;new technology;New York;next generation sequencing;novel;novel diagnostics;novel therapeutic intervention;Outcomes Research;Pathologist;Pennsylvania;Pharmacologic Substance;phenotypic data;Price;Privacy;Process;Production;programs;prospective;Protocols documentation;psychogenetics;public repository;Publications;quality assurance;Quality Control;Recovery;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;RNA;sample collection;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Secure;Service provision;Services;Shipping;Somatic Cell;success;System;Technology;Testing;Tissue Sample;tool;transcriptome;transcriptome sequencing;Trust;United States Department of Veterans Affairs;Universities;Veterans;volunteer;web portal;web site;whole genome;Work

PROJECT_TITLE: Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

PHR: NARRATIVE  Although the intrauterine setting is considered to be a safe environment for the fetus, microbes have been detected in gestational tissues in normal asymptomatic pregnancies. The proposed studies in this grant address novel and cutting-edge concepts regarding the role of placenta-specific microRNAs in regulating exaggerated inflammation after repeated infections during pregnancy. These studies may set the stage to the identification of biomarkers and targets to treat inflammation related to preterm births and other inflammation-associated pathologic pregnancies.

PI_NAMEs: HANNA, NAZEEH N (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Attenuated;Bacterial Toxins;Biological Markers;biomarker identification;candidate marker;cell type;Cells;Clinical;Data;Disease;Distant;Dose;Down-Regulation;Endometrial;Environment;Equilibrium;Exhibits;experimental study;Exposure to;extracellular vesicles;fetal;Fetus;Future;Grant;healthy pregnancy;Histologic;Host Defense;Human;human disease;Immune;Immune response;Immune system;Immune Tolerance;Immunosuppression;implantation;Infection;Inflammation;Inflammatory;Inflammatory Response;intraamniotic infection;intrauterine environment;Invaded;Link;Maintenance;Maternal-Fetal Exchange;Mediating;Microbe;MicroRNAs;Modeling;Molecular;mortality;Mothers;Mus;novel;Organism;pathogen;pathogenic microbe;Pathologic;Phenotype;Placenta;placental trophoblasts;Placentation;Play;Pregnancy;Pregnancy Trimesters;Pregnant Women;Premature Birth;prevent;Production;Research;Role;Signal Transduction;Stimulus;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;Uterine Contraction;Woman

PROJECT_TITLE: Placenta-specific miR-519c-mediated induction of immune tolerance in human placenta

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE We aim to develop effective immunotherapy for glioblastoma multiforme (GBM) by deploying IL-13Rα2/TGF-β bispecific chimeric antigen receptor (CAR)-T cells that can both (a) directly target GBM through IL-13Rα2 surface-antigen recognition and (b) modify the tumor microenvironment by converting TGF-β from an immunosuppressant into a stimulant of engineered CAR-T cells. We will evaluate the ability of IL-13Rα2/TGF-β CAR-T cells to directly eliminate IL-13Rα2+ GBM, as well as to induce endogenous immunity against IL-13Rα2– GBM, in both patient-derived orthotopic xenograft models and immunocompetent mouse models. This work will rigorously evaluate the safety and toxicity profile of IL-13Rα2/TGF-β CAR-T cell therapy, and generate comprehensive preclinical data in support of a phase-1 clinical trial for the treatment of patients with GBM.

PI_NAMEs: CHEN, YVONNE YU-HSUAN (contact)

PROJECT_TERMS: Alpha Interleukin 2 Receptor;Antigens;Autopsy;beta Chain Antigen T Cell Receptor;Biopsy;Bone Marrow;Brain;C57BL/6 Mouse;CAR T cell therapy;Cell Physiology;Cells;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical translation;Clinical Treatment;cytokine;Cytometry;Data;Dominant-Negative Mutation;effective therapy;engineered T cells;Engineering;Environment;Epitope spreading;Evaluation;Feedback;Flow Cytometry;Genetic Heterogeneity;Glioblastoma;Glioma;Heterogeneity;Human;IL13RA1 gene;Immune;Immune response;Immune system;Immunity;Immunocompetent;Immunofluorescence Immunologic;Immunohistochemistry;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;in vivo;Infiltration;Inflammatory;Intravenous;Libraries;Lymphocyte;Malignant neoplasm of brain;Medical;Mesenchymal;Modeling;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;novel;Patients;Phase I Clinical Trials;Phenotype;Play;pre-clinical;preservation;pressure;Primary Brain Neoplasms;Proliferating;recruit;Reporting;Resected;response;Route;Safety;Signal Transduction;single-cell RNA sequencing;Specificity;Spleen;Stimulant;Surface Antigens;Survival Rate;T-Lymphocyte;targeted treatment;Testing;Time;Toxic effect;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transforming Growth Factor beta Receptors;translational potential;treatment group;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Programming multi-pronged immune response to glioblastoma with IL-13Ra2/TGF-b CAR-T cell therapy.

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE: The gut-brain axis has recently been identified as a key player in the pathogenesis of neurodegenerative diseases (NDD), most notably in Alzheimer’s disease (AD). A growing body of evidence suggests that dysfunctional gut and its microbe-derived factors may contribute to central amyloid pathogenesis. These studies will provide novel and alternative strategies for prevention/ intervention in AD and other dementias.

PI_NAMEs: GANESH, BHANU PRIYA (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: abeta accumulation;abeta deposition;absorption;Acceleration;Acute;AD transgenic mice;Affect;Age;Age Months;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Amyloid deposition;Amyloid Proteins;Anabolism;Animals;Antigens;Bacteria;behavior test;beta amyloid pathology;Bilateral;Biological Process;Blood;Brain;Brain Diseases;Breeding;Cells;Central Nervous System;cerebral amyloidosis;Circulation;Cognitive deficits;Communication;Complement;Complex;confocal imaging;cytokine;Data;Dementia;Demyelinations;Dextrans;Diet;Disease;Disease Progression;dysbiosis;E-Cadherin;Environment;Etiology;extracellular;Fermentation;Foundations;Functional disorder;gastrointestinal epithelium;Gastrointestinal tract structure;gut homeostasis;gut inflammation;gut-brain axis;Homeostasis;Human;Immune system;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;insight;Intervention;Intestines;intrinsic factor-cobalamin receptor;Knockout Mice;Lactobacillus reuteri;Life;Link;Maintenance;Malabsorption Syndromes;Mass Spectrum Analysis;Measures;Mediating;Memory impairment;Microbe;Microbial Biofilms;microbiota;microbiota composition;mouse model;Mucous body substance;Mus;mutant;Myelin;Myelin Sheath;myelination;Neurodegenerative Disorders;Neurons;novel;nutrient absorption;Oligodendroglia;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peripheral;prevent;Prevention strategy;prion-like;Production;Proteins;receptor;receptor expression;repaired;Research;response;Role;Secondary to;Senile Plaques;Severities;Sodium;Staphylococcus aureus;Symptoms;Testing;Tg2576;Tight Junctions;Transgenic Mice;Transgenic Model;Transgenic Organisms;two-photon;β-amyloid burden

PROJECT_TITLE: Link between early gut dysfunction and amyloid beta aggregation in Alzheimer's Disease related dementia


NIH_SPENDING_CATS: Genetics

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: Project Narrative DNA damage arising from oxidative stress promotes multiple human diseases, and the cell’s primary defense against these lesions is the base excision repair (BER) pathway. The overarching goal of this study is to elucidate the molecular mechanisms coupling two key biological tasks in response to oxidative DNA damage at certain G-quadruplex promoter sequences –specifically, BER and the transcription of specific genes. I will employ elegant biochemical and human cell- based approaches to elucidate the crosstalk between DNA repair and transcription, while developing the research and professional skills needed to be a successful independent investigator.

PI_NAMEs: WHITAKER, AMY MICHELLE (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Address;Applied Skills;Back;base;Base Excision Repairs;Beverages;Binding;Binding Sites;Biochemical;Biological;Biological Assay;biophysical analysis;C-terminal;Cells;Consumption;Coupled;Coupling;Data;Development;DNA;DNA Damage;DNA lesion;DNA ligase III;DNA Repair;DNA Sequence;DNA Structure;Educational process of instructing;Environmental Exposure;Enzymatic Biochemistry;Epigenetic Process;Equilibrium;Event;Excision;experimental study;Exposure to;Fluorescence;Food;Foundations;G-Quartets;Gene Activation;Gene Expression;Gene Modified;Generations;Genes;Genetic Transcription;Genome;Goals;Grant;Guanine;Hot Spot;Human;human disease;Hypoxia;interdisciplinary approach;Kansas;Kinetics;Lesion;Life Style;Medical center;Mentors;Modeling;Modification;Molecular;Molecular Conformation;N-terminal;Nucleic Acids;OGG1 gene;Oxidation-Reduction;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Phase;pollutant;Predisposition;promoter;Promoter Regions;Proteins;Publications;Reaction;Reactive Oxygen Species;reconstitution;recruit;repair enzyme;repaired;Research;Research Personnel;Resources;response;Role;Series;single molecule;single-molecule FRET;Site;skills;Structure;Technical Expertise;Techniques;Testing;Time;Training;transcription factor;Transcriptional Activation;Transcriptional Regulation;transversion mutation;Ultraviolet Rays;United States National Institutes of Health;Universities;Vascular Endothelial Growth Factors;Work;Writing;X-Ray Crystallography;XRCC1 gene

PROJECT_TITLE: Repair of Oxidative Damage in G-Quadruplex Promoter DNA

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Despite a history of successfully receiving a kidney transplant, patients with graft failure have wide variations in their access to preemptive listing and peritoneal dialysis. The goal of this study is to understand barriers to the pursuit of PD and re-listing in patients who develop graft failure, and to identify modifiable factors that can be intervened upon to improve access to these preferred modalities of kidney replacement therapy, particular as it applies to disadvantaged populations.

PI_NAMEs: JOHANSEN, KIRSTEN L.;KU, ELAINE  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: access disparities;Address;Allografting;American;Attitude;Awareness;Black Populations;Black race;Caring;Collaborations;cost;Data;Dialysis procedure;Disease;disease registry;Disparity;Disparity population;Education;electronic health data;Electronic Health Record;electronic health record system;End stage renal failure;Equity;ethnic disparity;Evaluation;experience;Exposure to;falls;follow-up;frailty;Frequencies;Future;Glomerular Filtration Rate;Goals;graft dysfunction;graft failure;graft function;Health;Health Services Accessibility;Hemodialysis;Hispanic;Hispanic Populations;Home;Improve Access;improved outcome;Incentives;Individual;Information Systems;Insurance Carriers;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Link;Living Donors;Longevity;Medicaid;Medicare;Methods;Modality;Modeling;Nephrology;Not Hispanic or Latino;Organ Donor;Participant;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;Perception;Peritoneal Dialysis;Phase;Policies;Population;predictive modeling;Preparation;Prevalence;Privatization;Provider;Quality of life;racial disparity;Recording of previous events;Renal Replacement Therapy;Resistance;retransplantation;Risk;social health determinants;Structure;Surveys;System;Time;tool;transplant centers;Transplant Recipients;Transplantation;United States;Variant;Visit;Waiting Lists

PROJECT_TITLE: Reaching Equity in ACess to Home Dialysis And Re-Transplantation (REACH-DART)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE P. aeruginosa is a principal pathogen in cystic fibrosis and hospital-acquired infections; its pathogenicity is linked to biofilm formation. Here we aim to further the research of our current RO1 and deeper characterize a pathway for biofilm regulation in P. aeruginosa. The proposed research is relevant to public health because the discovery of new pathways that regulate biofilm growth will provide new targets for preventive and therapeutic interventions. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will extend healthy life and reduce the burdens of illness.

PI_NAMEs: BOON, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: acute infection;Aerobic;Affinity;Antibiotic Resistance;Antibiotics;arm;Bacteria;Binding;Binding Proteins;Biochemical;Biochemical Process;Biological Assay;burden of illness;Chronic;chronic infection;Clinical;Cystic Fibrosis;Data;denitrification;Development;experience;Failure;Family;Feedback;forging;Funding;Genes;Goals;Growth;Hemeproteins;Histidine;human pathogen;Infection;Infection Control;infectious disease treatment;inhibitor;innovation;inorganic phosphate;Intervention;Knowledge;Laboratories;Life;Ligation;Link;Measures;member;Microbial Biofilms;Mission;Molecular;Motility;mutant;Nitrates;Nitric Oxide;Nitrites;Nosocomial Infections;novel;novel therapeutics;Organism;Oxidoreductase;pathogen;Pathogenicity;Pathway interactions;Periodicity;Phenotype;Phosphorylation;Phosphotransferases;preventive intervention;protein-histidine kinase;Proteins;protoporphyrin IX;Pseudomonas aeruginosa;Public Health;Pyocyanine;quorum sensing;Regulation;Research;Respiration;response;Risk;Role;sensor;Signal Pathway;Signal Transduction;small molecule;Source;System;Testing;Therapeutic;Therapeutic Intervention;Transcript;United States National Institutes of Health;Up-Regulation;Virulence;Work

PROJECT_TITLE: The role of NosP in Pseudomonas aeruginosa biofilm development

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Hematology;Lung;Lung Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Lung and triple-negative breast cancers are leading causes of cancer-related deaths in the U.S., and the lethality of these diseases is largely due to their propensity to rapidly form metastases. We have recently found that tumor angiogenesis influences both immune cell recruitment and the surrounding extracellular matrix. In this proposal, we will study how tumor endothelial cell heterogeneity and immune cell recruitment leads to fibrin remodeling and cancer progression.

PI_NAMEs: DUDLEY, ANDREW CARL;PECOT, CHAD V (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Binding;Bioinformatics;Blood Vessels;Breast Cancer Model;Cancer Etiology;cancer type;CCL2 gene;cell motility;Cells;Cessation of life;Characteristics;clinical investigation;Communication;crosslink;CXCR4 gene;Death Rate;density;Deposition;Disease;Disease Progression;disorder control;Endothelial Cells;Extracellular Matrix;extracellular vesicles;Factor XIIIa;Fibrin;Fibrinolysis;Genetic;Heterogeneity;human disease;Hydrogels;Immune;immune checkpoint blockade;improved;in vivo;indexing;Inflammatory;inhibitor;insight;Kinetics;Lung;Lung Adenocarcinoma;Mediating;Microfluidics;Modeling;Molecular Probes;monocyte;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;novel;Oncogenes;pharmacologic;Plasminogen Activator Inhibitor 1;programs;recruit;Regulation;Reporter;Reporting;RNA-Binding Proteins;Role;scaffold;Signal Transduction;Squamous Cell Lung Carcinoma;Stromal Cell-Derived Factor 1;support network;targeted treatment;Transforming Growth Factor beta;triple-negative invasive breast carcinoma;tumor;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;ultrasound;vascular factor;wound healing

PROJECT_TITLE: Tumor Endothelial Cell Regulation of Pro-Metastatic Fibrin Matrices

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Chronic inflammation in the stomach is associated with gastric diseases, including gastric cancer, a leading cause of cancer related deaths. This proposal is focused on understanding the cellular and molecular mechanisms by which inflammatory cells and cytokines induce gastric metaplasia and its progression to cancer. This knowledge is expected to improve our understanding of inflammation induced metaplasia and inform strategies to diagnose and treat gastric diseases and gastric cancer.

PI_NAMEs: DIPAOLO, RICHARD J (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acceleration;Address;autoimmune gastritis;Cancer Etiology;cancer risk;carcinogenesis;CD4 Positive T Lymphocytes;Cell secretion;cell type;Cells;Cessation of life;Chronic;Chronic Gastritis;Coculture Techniques;cytokine;Data;design;Development;Diagnosis;Diagnostic;digital;disease model;Disease Progression;disorder risk;Environmental Risk Factor;Epithelium;experimental study;Gastric Adenocarcinoma;Gastric Metaplasia;Gastric mucosa;gastric organoids;Gastric Tissue;gastric tumorigenesis;Gastritis;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Growth;Helicobacter Infections;Helicobacter pylori;Human;human disease;human tissue;IL17 gene;IL4 gene;Immune;Immune response;improved;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Integration Host Factors;Interferon Type II;Interleukin-13;Knowledge;Lesion;Link;Malignant Neoplasms;malignant stomach neoplasm;mast cell;Mediating;Metaplasia;Metaplastic Cell;Methods;Molecular;mouse model;Mus;nano-string;neoplastic;Organoids;premalignant;Prevalence;prevent;Prevention;Production;response;Risk;RNA analysis;Role;Signal Transduction;Source;Stomach;Stomach Diseases;Stomach Neoplasms;T-Lymphocyte;Technology;Testing;Th1 Cells;Th2 Cells;Therapeutic;Tissue Sample;Tissues;Transcript;transcriptome sequencing;transcriptomics;translational study;treatment strategy;tumor;tumorigenesis

PROJECT_TITLE: The Role of Inflammation in Regulating Gastric Metaplasia

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]