NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Continuous glucose monitoring devices have improved glycemic and quality-of-life outcomes in persons with type 1 diabetes and have become the standard of care. However, significant and persistent disparities in their use have emerged, particularly in Black and Latinx youth, in whom rates of adoption and continued use trail behind their non-Latinx white counterparts. Developing and evaluating effective strategies to facilitate successful diabetes technology use that is developmentally and culturally responsive to Black and Latinx youth are critical and necessary steps to mitigate disparities and improve metabolic and behavioral health in adolescents with type 1 diabetes.

PI_NAMEs: WEINZIMER, STUART ALAN (contact);WHITTEMORE, ROBIN G

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adolescent;Adoption;Age;age group;AIDS prevention;Alcohol consumption;Attitude;Behavior;behavioral health;behavioral outcome;Black race;Blood Glucose;Caring;Chronic;Chronic Disease;Clinical;clinical care;Clinical Management;Clinical Trials;Collaborations;Communication;comparison control;Conduct Clinical Trials;Continuous Glucose Monitor;Control Groups;Development;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Disease Management;Disparity;disparity reduction;Distress;drug abuse prevention;efficacy evaluation;Emotional;Enrollment;ethnic disparity;Ethnic Population;Evaluation Studies;experience;Feasibility Studies;Feeling;Frustration;Future;Glucose;glycemic control;Health;health inequalities;Health Personnel;health related quality of life;Hypoglycemia;improved;innovation;Insulin-Dependent Diabetes Mellitus;Insurance Coverage;Intervention;Latinx;Life Style;Maintenance;meetings;Metabolic;Minority;Modeling;Monitor;monitoring device;Multi-Institutional Clinical Trial;Outcome;Parents;Participant;Patients;Pattern;peer coaching;peer support;Persons;Phase;Pilot Projects;Population;primary outcome;Privatization;Problem Solving;Process;programs;Protocols documentation;Quality of life;racial disparity;racial population;Randomized;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Reporting;Research;Research Design;response;role model;Sampling;scale up;secondary outcome;Self Efficacy;Self Management;Site;smoking cessation;social media;social situation;Socioeconomic Factors;socioeconomics;standard care;standard of care;Structure;Technology;Teenagers;Time;Training;trend;uptake;Validation;Work;young adult;Youth

PROJECT_TITLE: Glu-COACH: a peer-mentoring intervention to reduce disparities in CGM use in adolescents with type 1 diabetes


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pulmonary hypertension leads to right heart failure and death. Mechanistic details of right heart failure remain elusive with no approved therapies directly targeting the failing right heart. This proposal investigates the role of Snai1-LOXL2-CTGF axis in endothelial-to-mesenchymal-transition and fibrosis associated with right heart failure and proposes targeting Snai1 and/or LOXL2 as novel therapeutic strategies.

PI_NAMEs: UMAR, SOBAN  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Arrhythmia;Binding;Blood flow;Cardiac;Cardiac Myocytes;cell type;Cells;Centromere;Cessation of life;Chromatin;chromatin remodeling;Chronic;connective tissue growth factor;Coronary;Coronary artery;Data;Development;DNA Methylation;DNMT3a;Endothelial Cells;Endothelium;Enzymes;epithelial to mesenchymal transition;Event;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;Functional disorder;functional improvement;Gatekeeping;Gene Expression Profile;Genes;Goals;Heart;Histologic;Histone H3;Human;Human Rights;Hypertrophy;Hypoxia;Impairment;In Vitro;in vitro Model;in vivo;innovation;insight;Investigation;KDM1A gene;knock-down;Knowledge;LOXL2 gene;Lung;Mediating;Mesenchymal;Methylation;migration;Modeling;Modification;Molecular;Molecular Analysis;Monocrotaline;Morbidity - disease rate;mortality;Myofibroblast;new therapeutic target;normoxia;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;pre-clinical;prognostic;prognostic significance;promoter;pulmonary arterial pressure;Pulmonary Hypertension;Rattus;recruit;right ventricular failure;Right Ventricular Function;Right Ventricular Hypertrophy;right ventricular remodeling;Role;Secondary to;Series;Signal Pathway;Smooth Muscle Myocytes;Snails;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Tissues;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;TWIST1 gene;Ventricular

PROJECT_TITLE: Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative This project will focus on how a particular class of bacterial systems controls important aspects of bacterial survival and lifestyle decisions such as antibiotic resistance and the transition to an infective state. The mechanistic insights we gain on these systems will be critical for developing new and improved anti-infective strategies and new antibiotics.

PI_NAMEs: LIBBY, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Anti-Infective Agents;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Appearance;Architecture;Bacillus subtilis;Bacteria;Bacterial Physiology;Behavior;Cell division;cell growth;Cell Physiology;Cells;Clinical;Competence;Cues;Development;Disease;Environment;Enzymes;Generations;Germination;Goals;Health;Human;improved;insight;Laboratories;Life Style;Microbial Biofilms;model organism;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiological;Population;Post-Translational Protein Processing;Protein-Serine-Threonine Kinases;Regulation;response;Role;Serine;Signal Transduction;System;transcription factor;Transcriptional Regulation;Virulence

PROJECT_TITLE: Physiological and Developmental Role of Bacterial Ser/Thr Kinases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Humans with mutations in CLCN6, which encodes the ClC-6 chloride channel, have reduced hypertension risk, therefore, ClC-6 may be revealed as a possible novel therapeutic target, but more information about its function is essential. These studies will form a necessary foundation for the role of the channel encoded by the CLCN6 gene and provide mechanistic insight into its physiological functions and the molecular processes controlled by this understudied transporter.

PI_NAMEs: KLEMENS, CHRISTINE ANNE (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acetylcholine;Address;Adult;Affect;Animal Experimentation;Animal Model;Apoptosis;Apoptotic;Applications Grants;arterial stiffness;Arteries;ATP phosphohydrolase;Biochemical;Biological Assay;Biological Models;biophysical properties;Blood Pressure;blood pressure control;blood pressure reduction;blood pressure regulation;Blood Vessels;Bromodeoxyuridine;burden of illness;Ca(2+)-Transporting ATPase;Calcium;Cardiac;Carrier Proteins;Cell Physiology;Cell Proliferation;Cellular biology;Charge;Chloride Channels;Chlorides;Code;Compensation;Contracts;Coupling;Dahl Hypertensive Rats;Data;Deposition;Development;Diet;economic impact;Electrophysiology (science);Endoplasmic Reticulum;Equilibrium;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Foundations;Future;Genes;genome wide association study;Goals;Golgi Apparatus;health economics;Heart failure;Histologic;Histology;Human;Hypertension;hypertensive;Image;In Situ Nick-End Labeling;In Vitro;Injury to Kidney;insight;Investigation;Ions;Kidney;Kidney Diseases;Knock-out;Link;Lipid Bilayers;Measurement;Measures;Medial;Membrane;Mentors;migration;Migration Assay;Mitochondria;Molecular;Molecular Biology;mRNA Expression;Muscle Contraction;Mutation;Myocardial Infarction;Myography;new therapeutic target;normotensive;novel;Organelles;Pathologic;Peripheral;Phase;Phenotype;Physiologic pulse;Physiological;Play;Population;Post-Translational Protein Processing;Postdoctoral Fellow;prevent;Process;programs;Property;protein expression;protein function;Protein Secretion;protein transport;Proteins;Protocols documentation;Rattus;reconstitution;Research;Resistance;response;Risk;Role;Signal Pathway;Signal Transduction;skills;Smooth Muscle Myocytes;socioeconomics;Sodium Chloride;Stimulus;Stroke;stroke risk;therapeutic target;transcriptomics;Translating;uptake;Variant;Vascular resistance;Vascular Smooth Muscle;voltage;Work;wound healing

PROJECT_TITLE: The Role of CIC-6 in Vascular Control of Blood Pressure

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: HMG-CoA reductase (HMGR), a key enzyme of cholesterol synthesis and the target of statins in the clinic, is regulated by controlled degradation. We have discovered the mechanism of regulated degradation, called mallostery, in which a protein quality control pathway is harnessed for selective HMGR destruction. We are exploring the features of mallostery, to understand its role in a growing number of cellular processes, and as an exciting avenue towards an entirely new class of pharmaceutical agents.

PI_NAMEs: HAMPTON, RANDOLPH Y. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Allosteric Regulation;analog;antagonist;Biochemical;Biochemical Process;Biological Assay;Biology;Carbon;Cell Physiology;Cellular Stress;Chemicals;Cholesterol;Clinic;Dangerousness;Degradation Pathway;Development;drug discovery;Endoplasmic Reticulum Degradation Pathway;Enzymes;Evolution;Feedback;Funding;Genetic;genetic approach;Genetic Screening;genomic platform;Glean;Homeostasis;Human;In Vitro;Isoenzymes;isoprenoid;Laboratories;Lanosterol;Life;Ligands;Lipids;Mammals;Mediating;Membrane;Metabolic;Methods;misfolded protein;Mission;Molecular;mutant;Names;Oxidoreductase;Pathology;Pathway interactions;Pharmacologic Substance;Physiology;Play;Predisposition;prevent;protein folding;Proteins;Quality Control;reconstitution;Regulation;response;Rest;Role;screening;Signal Pathway;Signal Transduction;Specificity;Sterols;Structure;Testing;tool;translational applications;translational potential;Transmembrane Domain;Ubiquitin;Ubiquitination;Variant;Yeasts

PROJECT_TITLE: Mallosteric Regulation of the Sterol Pathway

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This proposed U54 Collaborative Partnership between NCCU and UNC involves increasing NCCU alcohol research and student research experiences in fetal alcohol toxicity, alcohol neurotoxicity, and alcohol-induced carcinogenesis and inflammation. Health disparities include increased severity of alcohol-related pathology. Collaborative partnerships that carry out integrated and focused research on the molecular mechanisms of alcohol pathology involving faculty and students from NCCU, a historically Black College or University, educate and involve future researchers on alcohol-related health disparities and provide opportunities for careers in medical fields as well as making discoveries on mechanisms that may lead to cures.

PI_NAMEs: CREWS, FULTON T (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adolescent;Adult;African American;African American population;African American student;Alcohol abuse;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Area;ARHGEF5 gene;Award;Behavioral;Brain;carcinogenesis;career;cellular pathology;Collaborations;Core Facility;Course Content;Data;Education;Educational Curriculum;Educational process of instructing;Endowment;Environment;Ethanol toxicity;expectation;experience;experimental study;Faculty;faculty mentor;fetal;Fetal Alcohol Spectrum Disorder;Funding;Future;Goals;graduate student;Grant;health disparity;Health Professional;Historically Black Colleges and Universities;improved;Inflammation;Infrastructure;Institution;interest;Internships;Joints;Knowledge;Laboratories;laboratory development;laboratory experience;Laboratory Research;Leadership;Learning;lectures;Malignant Breast Neoplasm;mammary;Manuscripts;Medical;Medical Libraries;medical schools;meetings;Mentors;Minority;minority investigator;Molecular;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;Neuroimmune;neuropathology;neurotoxicity;North Carolina;Pathology;post-doctoral training;Preparation;Process;Productivity;programs;Publications;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Technics;Resource Sharing;Resources;response;role model;Scholarship;Series;Severities;skills;stem cells;Structure;Students;success;summer internship;synergism;Techniques;Tissues;Toxic effect;Training;U-Series Cooperative Agreements;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;virology;Work

PROJECT_TITLE: 2/2 Partnerships to Enhance Alcohol Research Across NCCU and UNC (PEAR-NC)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Building Research Capacity at Institutions with Limited NIH Funding;Substance Misuse

PROJECT_TERMS: Accounting;Advocate;African American;alcohol research;alcohol use disorder;Alcohols;Applications Grants;Bachelor's Degree;Biomedical Research;Budgets;career;Collaborations;Data;Development;Doctor of Philosophy;doctoral student;Education;Enrollment;Environment;experience;Faculty;faculty research;Foundations;Funding;Future;Goals;Graduate Degree;graduate student;health disparity;Health Occupations;Hispanic;Historically Black Colleges and Universities;Human Resources;Institution;Joints;Laboratories;Laboratory Research;Lead;Leadership;Manuscripts;meetings;Mentors;Mentorship;Methodology;minority scientist;Minority-Serving Institution;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;North Carolina;organizational structure;Outcomes Research;Participant;Pathology;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;programs;Publications;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Rewards;Schedule;Series;Services;Structure;student mentoring;student training;Students;success;synergism;Techniques;Training;Training Activity;Training and Education;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: COLEMAN, LEON GARLAND (contact)

PROJECT_TERMS: Academia;Address;alcohol research;Alcohols;career;career development;Collaborations;Communication;Complex;Dental Schools;design;Development;Disparity;Doctor of Philosophy;doctoral student;educational atmosphere;Educational process of instructing;evidence base;experience;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate student;Grant;improved;Infrastructure;Institution;Instruction;interest;Laboratories;Laboratory Research;Learning;matriculation;medical schools;member;Mentors;Mentorship;method development;Methods;Minority Groups;minority investigator;minority scientist;National Institute on Alcohol Abuse and Alcoholism;Population Heterogeneity;Postdoctoral Fellow;Productivity;programs;Research;research and development;Research Personnel;Research Project Grants;Resources;responsible research conduct;Scholarship;Science;skill acquisition;skills;Structure;student mentoring;Students;success;summer research;symposium;Techniques;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Writing

PROJECT_TITLE: Scientific Mentoring and Research Experiences Core


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed activities will bring new insights from neighborhood research into the geroscience domain by extending studies of neighborhood disadvantage and brain health into the middle-age phase of life, where dementia prevention may be possible. This work will inform the identification of high-risk individuals and significantly advance the evidence base needed for developing neighborhood-level dementia prevention efforts. The long-term goal of this line of research is to lower the global burden of degenerative brain disease through better understanding of modifiable risk factors for dementia and improved identification of at-risk individuals before disease end-points emerge.

PI_NAMEs: REUBEN, AARON  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Age;age related;Aging;aging brain;Air Pollution;Amber;Archives;behavior change;Birth;Brain;Brain Diseases;brain health;career;career preparation;Characteristics;Clinical;cognitive ability;Cognitive aging;cognitive change;cognitive function;cognitive performance;cognitive testing;cohort;Data;Data Linkages;data resource;Dementia;dementia risk;Development;Disadvantaged;Disease;disorder prevention;Economic Conditions;Educational process of instructing;Educational workshop;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;evidence base;Exposure to;Fellowship;follow-up;Future;Genetic;Geroscience;Goals;good diet;Grain;Grant;gray matter;Health;Health behavior;Health Care Sector;health disparity populations;high risk population;Hypertension;improved;Individual;Inequity;infancy;Inflammation;informant;innovation;insight;Intervention;Investigation;Leisures;Life;life span;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;member;Mentors;Mentorship;Methods;Michigan;middle age;Modeling;modifiable risk;neighborhood disadvantage;Neighborhoods;Nerve Degeneration;neuroimaging;Neurologic;neuropsychiatry;Neurotoxins;New Zealand;novel;older adult;Organ;Outcome;Pathologic;Patient Self-Report;Phase;Phenotype;Physical activity;Play;Policies;Population;prevent;Prevention;prospective;Psychology;psychosocial;Psychosocial Assessment and Care;Public Health;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Role;skills;social;Social Conditions;social stressor;sociodemographics;socioeconomics;Sports;stressor;Structure;symposium;Symptoms;System;Techniques;Testing;Time;Training;Training Activity;Universities;white matter;Work;Writing

PROJECT_TITLE: Investigating neighborhood-environment contributions to midlife risk for dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Genetics;Lung

ORG_CITY: Los Angeles

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Asthma remains an important source of morbidity and health care costs in the U.S. The overall goals of this project are to understand the molecular and cellular genes that regulate pro-inflammatory cells in the lungs and able to alleviate allergic asthma.

PI_NAMEs: AKBARI, OMID  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Address;Agonist;airway hyperresponsiveness;airway inflammation;Allergen Immunotherapy;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Alternaria;antagonist;Anti-Inflammatory Agents;Asthma;asthma model;Bioenergetics;Biological Assay;cell type;Cells;Chromatin;Chronic;Clinical;cytokine;Data;design;Disease;disease model;energy balance;Energy-Generating Resources;Enhancers;eosinophil;Event;experimental study;Extrinsic asthma;fatty acid oxidation;Generations;Genes;Genetic Transcription;Genus Hippocampus;Glycolysis;Goals;Health Care Costs;Hypersensitivity;Immune;Immune response;Immunity;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;insight;Intention;Interleukin-10;Interleukin-13;Interleukin-5;Knockout Mice;Laboratories;Link;Lung;Lymphoid Cell;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;Modeling;Modification;Molecular;Morbidity - disease rate;Morphology;mouse model;novel;novel therapeutic intervention;novel therapeutics;overexpression;Oxidative Phosphorylation;Pathogenicity;Patients;Play;Population;Process;Production;Property;Publishing;Pulmonary Inflammation;Regulation;Research;Respiratory Disease;Role;segregation;Series;Severities;Shapes;Signal Transduction;Signaling Protein;Source;Structure of parenchyma of lung;Symptoms;Technology;tissue injury;transcription factor;Transcriptional Regulation;Translating;translational approach

PROJECT_TITLE: Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2s

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

PHR: NARRATIVE: The current treatments for alcohol use disorders are not universally effective, so determining new therapeutic areas is of critical concern. Astrocytes, key regulators of the neuroimmune response and neurotransmission, represent a novel target by which to reduce excessive alcohol consumption. The results of the current study will explore the viability of reducing binge drinking and cognitive deficits through manipulating astrocytic regulations of neuroimmune and glutamate signaling.

PI_NAMEs: MARSHALL, SIMON ALEXANDER (contact)

PROJECT_TERMS: Addictive Behavior;Address;Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol use disorder;Alcohols;Amygdaloid structure;anakinra;Anti-Inflammatory Agents;Area;Astrocytes;Behavior;Behavioral;binge drinking;Biological Assay;Brain Injuries;Brain-Derived Neurotrophic Factor;Cells;Cognitive deficits;combat;Consummatory Behavior;Consumption;Country;cytokine;Darkness;Dependence;designer receptors exclusively activated by designer drugs;Development;drinking;Enzyme-Linked Immunosorbent Assay;Ethanol;Ethanol dependence;Event;experimental study;extracellular;Functional disorder;Future;G Protein-Coupled Receptor Signaling;GLAST Protein;Glial Fibrillary Acidic Protein;Glutamate Transporter;glutamatergic signaling;Glutamates;Grant;health disparity;health economics;Heavy Drinking;Hippocampus;Human;Immune;Immunocompetent;Immunohistochemistry;improved;Incidence;Inflammatory;inflammatory marker;Inflammatory Response;innovation;insight;Interleukin-1;Interleukin-1 beta;Interleukin-10;Intoxication;Lead;Link;Measures;Mediating;Memory;Memory impairment;Microdialysis;Minority;Modeling;Molecular;Morphology;Mus;Neuroimmune;Neuroimmune system;Neuroimmunomodulation;neuroinflammation;Neuronal Plasticity;neurotransmission;novel;novel therapeutics;object recognition;Phenotype;Play;prevent;Procedures;Production;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Regulation;Reporting;Research;response;Risk;Role;sex;Sex Differences;Signal Transduction;Site;socioeconomics;synaptic function;Testing;United States;uptake;Viral;Work

PROJECT_TITLE: The Reciprocal Relationship between Binge Drinking and Astrocytic Signaling


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as an understanding of those molecular pathways that modify sensitivity to prenatal alcohol exposure-induced birth defects is expected in the long-term to inform clinical practice and ultimately reduce the incidence and severity of Fetal Alcohol Spectrum Disorders (FASD). This objective will be met by applying two innovative and complementary approaches to assess in cell and animal models if novel genes or chemicals modulate the deficits elicited by ethanol exposure. Thus, the proposed research is relevant to the parts of NIH/NIAAA’s mission that pertains to characterizing biological mechanisms underlying FASD, identifying biomarkers of prenatal alcohol exposure, and ultimately will reveal fundamental and novel insights into the mechanism of ethanol-induced birth defects.

PI_NAMEs: WILLIAMS, KEVIN PETER (contact)

PROJECT_TERMS: Acetylcysteine;Address;Agonist;alcohol effect;alcohol exposure;alcohol research;alcohol sensitivity;Alcohols;Animal Model;Applications Grants;Attenuated;Behavioral;Behavioral Model;beta Actin;Biological;Biological Models;biomarker identification;brain abnormalities;Candidate Disease Gene;Cell Line;Cell model;Cells;Chemicals;Chick;Cilia;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;Congenital Abnormality;Craniofacial Abnormalities;Data;Defect;Development;differential expression;Digit structure;disease model;Drug Screening;Embryo;Embryonic Development;established cell line;Ethanol;experimental study;Faculty;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fishes;Fostering;Foundations;Future;gene environment interaction;gene interaction;Gene Modified;Genes;Genetic;Genetically Engineered Mouse;Goals;Growth;high throughput screening;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;innovation;insight;Intervention;Knock-out;Knockout Mice;Libraries;Limb Bud;Limb Development;Limb structure;Literature;Mentorship;Mission;Modeling;Molecular;Molecular Target;Morphology;mouse genetics;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;Pathway interactions;Pectoral;pharmacologic;postnatal;Predisposition;prenatal;Public Health;Research;Research Personnel;Research Project Grants;Research Proposals;Resistance;Role;Scientist;screening;Series;Severities;SHH gene;Signal Pathway;Signal Transduction;skeletal;small hairpin RNA;Small Interfering RNA;small molecule;small molecule libraries;smoothened signaling pathway;Sonic Hedgehog Pathway;Specific qualifier value;Stains;Technology;teratogenesis;Teratogenic effects;Teratogens;Testing;Tissues;transcriptome sequencing;Transfection;Transgenic Organisms;Tretinoin;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Visual;Zebrafish

PROJECT_TITLE: Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

PHR: PROJECT NARRATIVE Hypoglycemia is a dangerous condition resulting from exogenous insulin therapy in Type 1 Diabetes that could be remedied by endogenous glucagon secretion. We found that while alanine or glucose-dependent insulinotropic peptide (GIP) alone induce modest increases in glucagon secretion, the combination of alanine and GIP synergistically increase glucagon secretion. In this proposal, we will test the hypothesis that -cell secretion of glucagon is able to mitigate insulin-induced hypoglycemia.

PI_NAMEs: EL, KIMBERLEY M (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Adrenal Glands;Alanine;Alpha Cell;Amino Acids;Arginine;Automobile Driving;Awareness;Biological Assay;Biology;Blood Glucose;Brain;Carbohydrates;Carbon;career;Catecholamines;Cell Communication;Cell Physiology;Cells;Clinical;Cognition;Complex;Complication;counterregulation;Dangerousness;design;Diabetes Mellitus;diabetic;Dose;Drops;effective therapy;effectiveness evaluation;Emergency Situation;Emergency treatment;Energy-Generating Resources;Etiology;Exposure to;Foundations;Functional disorder;G-Protein-Coupled Receptors;Gastric Inhibitory Polypeptide;gastric inhibitory polypeptide receptor;Generations;Glass;Glucagon;Glucose;glucose output;glycemic control;Hepatic;Human;Hydrocortisone;Hypoglycemia;Impairment;in vivo;Ingestion;insight;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Label;Life;Measures;Metabolic;Metabolism;Methods;Modeling;Molecular;mouse model;Mus;Neurons;Non obese;novel;novel strategies;Pathway interactions;Patients;Persons;Physiological;Physiology;prevent;Recurrence;Research Personnel;response;Schedule;Serious Adverse Event;side effect;Stimulus;Strenuous Exercise;Streptozocin;System;Technical Expertise;Testing;Therapeutic;Variant;Wine;Work

PROJECT_TITLE: Targeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE This proposal will identify and characterize the posttranslational modifications (PTMs) of the proteome of emerging viruses (the `viral PTMome') as well as the modifying enzymes that control viral PTMs and thereby virus replication and pathogenesis. We will use an integrative approach that combines proteomics and gene-targeting screens with molecular, biochemical, and virus infection studies to address fundamental unanswered questions in virology, which will spur entirely new lines of treatment for a range of infectious diseases that represent public health threats.

PI_NAMEs: GACK, MICHAELA ULRIKE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Anti-viral Agents;Anti-viral Therapy;Biochemical;biophysical analysis;Cells;Chemicals;Communicable Diseases;Creativeness;Deacetylase;design;Deubiquitinating Enzyme;Development;Disease;emerging virus;Enzymes;Future;future outbreak;future pandemic;Gene Targeting;Genetic Techniques;Goals;HIV;Human;influenzavirus;inhibitor;innovation;insight;Life Cycle Stages;Maps;Molecular;Molecular Virology;Mutate;novel;pathogenic virus;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Post-Translational Protein Processing;prevent;Proteins;Proteome;Proteomics;Public Health;Regulation;Research;Resistance;reverse genetics;RNA Virus Infections;Role;Testing;therapeutic RNA;Transferase;ubiquitin isopeptidase;ubiquitin-protein ligase;Viral;Viral Pathogenesis;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Defining the viral PTMome: Towards the development of novel antiviral approaches


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE This project aims to investigate the effects of alcohol on mammary stem cell deregulation and genomic instability in mammary tumor initiation and development. The role of the alcohol metabolite, acetaldehyde, in this process and the consequent molecular changes will be studied using transgenic animal models. Results from this project are expected to advance our understanding of the mechanisms of alcohol-associated breast cancer risk.

PI_NAMEs: YANG, XIAOHE  (contact)

PROJECT_TERMS: Acetaldehyde;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol prevention;alcohol research;alcohol response;Alcohols;Animal Model;Animals;beta catenin;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Risk Factor;Breast Carcinogenesis;Breast Epithelial Cells;Cancer cell line;Cancer Etiology;cancer initiation;cancer stem cell;Cancerous;carcinogenesis;CD44 gene;Cell Line;Cell Separation;cell transformation;cell type;Cells;cellular targeting;chromosomal location;Chromosome abnormality;Chromosomes;clinically relevant;comparative genomic hybridization;Data;Detection;Development;diagnostic biomarker;Diet;DNA Damage;DNA Repair;DNA Repair Disorder;Early Diagnosis;ERBB2 gene;experience;Female;Flow Cytometry;Frequencies;Gene Dosage;Gene Mutation;Genetic;Genome;Genomic Instability;Genomics;genotoxicity;Hematopoietic stem cells;Histopathology;Human;Impairment;in vitro Model;in vivo;in vivo Model;Injury;insight;Invaded;ITGB3 gene;Karyotype determination procedure;Knock-out;Lesion;Liquid substance;Liver;Malignant - descriptor;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Mammary Tumorigenesis;Mammospheres;Mediating;Mediator;Methodology;migration;Modeling;Molecular;Mouse Mammary Tumor Virus;mouse model;Mus;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;novel diagnostics;Pathogenesis;Pathway interactions;Play;Population;premalignant;Premalignant Cell;Prevention;Process;Production;Recurrence;Reporting;Risk;Role;self-renewal;Signal Transduction;STAT3 gene;stem;stem cell expansion;Stem Cell Research;Stem cell transplant;stem cells;stemness;Testing;therapeutic target;three dimensional cell culture;tissue injury;tissue stem cells;Tissues;TNFSF11 gene;tool;Toxic effect;TP53 gene;Transgenic Animals;tumor;tumor initiation;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Alcohol-Associated Toxicity and Genomic Instability of Mammary Stem Cells


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This study will advance the current understanding of stress and deleterious aggression in captive nonhuman primates using an experimental social network approach that will allow the development of an adaptive management program for primate facilities that will enhance group stability and successfully reduce stress and deleterious aggression, and prevent severe outbreaks in group-housed rhesus macaques. The rhesus macaque is an important biomedical model for human health research and this research is relevant by addressing the 3R's and their effects on biomarkers of individual health in a well-established nonhuman primate model.

PI_NAMEs: MCCOWAN, BRENDA  (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acute;Address;Adopted;Adult;Aggressive behavior;allostatic load;Animals;arm;Biological Markers;Breeding;Cardiovascular system;Choices and Control;Chronic stress;cohesion;community-level factor;cost;cost effective;Cost Savings;Decision Making;design;Development;Disease Outbreaks;Economic Burden;Economics;Environmental Monitoring;Event;Excision;expectation;experimental study;feeding;Food;food resource;Funding;Health;health assessment;Health Promotion;Hospitalization;Housing;Human;Immune;improved;Individual;Industry;Intervention;Investigation;Laboratories;Location;Macaca;Macaca mulatta;male;Measures;member;Metabolic;Methodology;Methods;Modeling;Neurosecretory Systems;nonhuman primate;novel;Pathway Analysis;Personal Satisfaction;Personality;physical conditioning;Physiological;preference;prevent;Primates;Procedures;Process Assessment;programs;R24;Research;Resources;Rhesus;Scheme;Series;Signal Transduction;social;Social Controls;social group;Social Network;Stress;stress reduction;Stressful Event;Structure;System;Techniques;Testing;Time;Trauma;Treatment Efficacy;United States Department of Agriculture;United States National Institutes of Health;Visual;War;welfare

PROJECT_TITLE: Proactive Management to Improve Laboratory Macaque Breeding Colony Health and Well-being

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(55)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Our training program for “Translational Research In Alzheimer’s and Related Dementias (TRIAD)” will provide predoctoral and postdoctoral trainees with the cross-disciplinary knowledge and skills needed to discover, develop, and advance new treatments for Alzheimer’s disease and related dementias. Trainees will be provided with expertise in cutting edge approaches from molecular methods to preclinical approaches and translation to clinical research. Our highly collaborative, interdisciplinary, and supportive team-based environment at the University of Kentucky will produce the skilled workforce that is critically needed to conduct basic, translational, and clinical research for Alzheimer’s disease and related dementias.

PI_NAMEs: MURPHY, MICHAEL PAUL;VAN ELDIK, LINDA J (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's disease related dementia;Training;Translational Research

PROJECT_TITLE: Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: MADISON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The public health relevance of MIDUS is its rich contributions to knowledge of how psychological and social experiences in early and middle adulthood matter for later life health and wellbeing. Psychosocial factors are recognized as protective resources as people deal with varieties of adversity, and MIDUS is at the forefront of explaining how they promote resilience by linking them to biology and neuroscience. Importantly, many of these psychosocial factors are modifiable, making them powerful targets for prevention and promotion of positive health among U.S. adults.

PI_NAMEs: RYFF, CAROL D. (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Adult;affective neuroscience;Age;Age Distribution;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Archives;Attention;Baseline Surveys;Behavioral;Biological;Biological Assay;Biological Markers;Biology;biopsychosocial;caregiving;Chronic;Clinical Trials Data Monitoring Committees;Cognitive;cognitive function;cognitive testing;Communities;Complex;computerized;COVID-19 pandemic;Data;Data Collection;Data Set;design;diaries;Documentation;Drops;Educational workshop;emotion regulation;Ensure;Event;experience;follow-up;Funding;Gene Expression;Gene Expression Regulation;genomic data;Genomics;Health;health inequalities;Health Sciences;healthy aging;Impaired cognition;Individual;Inequality;Intervention;journal article;Knowledge;late life;Life;Link;Longitudinal Studies;Measures;Metadata;Methodology;middle age;Minority;Modeling;Monitor;Morbidity - disease rate;mortality;National Archive;neurobiological mechanism;Neurobiology;Neurosciences;Outcome;Participant;Pathway interactions;perceived discrimination;Personal Satisfaction;Persons;Physiology;Politics;prevent;Prevention;promote resilience;protective factors;psychologic;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;psychosocial resources;public health relevance;Publications;Publishing;Quality Control;racial disparity;recruit;Recurrence;Research;resilience;resilience research;Resources;Running;Sample Size;Sampling;social;sociodemographic factors;sociodemographics;socioeconomic disparity;socioeconomics;statistics;Stress;Surveys;Testing;Time;tool;Translating;Universities;virtual;Work

PROJECT_TITLE: Integrative Pathways to Health and Illness


PROJECT_TERMS: access restrictions;affective neuroscience;African American;Agreement;Alzheimer's disease related dementia;Biological Markers;biopsychosocial;Cessation of life;Classification;Clinical Trials Data Monitoring Committees;Code;Cognitive;cognitive neuroscience;Communication;Communities;Complex;Custom;Data;Data Collection;data management;data portal;data quality;data resource;Data Set;Database Management Systems;Descriptor;diaries;disability;Disputes;Documentation;Funding;genome repository;Genomics;Geography;Goals;Grant;Health;health care service utilization;improved;indexing;Information Networks;innovation;Institutional Review Boards;interest;Leadership;Link;longitudinal analysis;Measures;Medicare;meetings;member;Metadata;Modification;Monitor;Morbidity - disease rate;mortality;mortality statistics;neuroimaging;Neurosciences;Occupational;Occupations;Online Systems;Participant;Pathway interactions;Pharmaceutical Preparations;population survey;Principal Investigator;Procedures;Quality Control;Records;recruit;Reporting;repository;Research;Research Personnel;Respondent;Sampling;Schedule;Secure;Standardization;Support System;Surveys;symposium;Technology;Time;timeline;tool;Update;user-friendly;web portal;webinar;Work

PROJECT_TITLE: Core A -- Administrative Core


NIH_SPENDING_CATS: Aging

PI_NAMEs: COE, CHRISTOPHER L (contact)

PROJECT_TERMS: Aliquot;Alzheimer's disease related dementia;Alzheimer's disease risk;Antioxidants;Biological;Biological Assay;Biological Markers;biomarker panel;Blood;Blood Tests;Body Fluids;bone turnover;Catecholamines;Cell Separation;Cells;Certification;chemokine;Clinical;Code;Collection;Consultations;cytokine;Data;Data Files;data sharing;Development;diaries;Dryness;Education;Educational workshop;Endocrine;Ensure;experience;Fluorescence;Freezing;Future;Gene Expression;Genetic Transcription;Health;Hematology;High Density Lipoproteins;Home;Hormones;Hydrocortisone;Immunoassay;Immunology procedure;Inflammatory;Information Dissemination;Infrastructure;Institutional Review Boards;Laboratories;Link;liquid chromatography mass spectrometry;Liquid substance;Location;Mass Spectrum Analysis;Measures;meetings;Mentors;Metabolic;Methodology;Methods;Mission;Monitor;Needs Assessment;Nitrogen;operation;Paper;Participant;Pathway interactions;Performance;Peroxidases;Preparation;Process;Protocols documentation;psychosocial;Public Domains;Publications;quality assurance;Quality Control;Records;Reporting;repository;Research Personnel;Resources;Risk;Role;Saliva;Salivary;Sampling;Site;Specimen;Spottings;Standardization;System;Test Result;Testing;Time;transmission process;urinary;Workload

PROJECT_TITLE: Core B -- BioCore


NIH_SPENDING_CATS: Aging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Neurosciences

PROJECT_TERMS: Address;Age;Aging;Alzheimer's disease related dementia;Area;Biological;Biological Markers;cohort;Cohort Effect;Collaborations;Communities;Complement;Complex;Consultations;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Data Analytics;Data Linkages;design;Development;DNA Methylation;Economics;Educational workshop;Event;Exercise;experience;Experimental Designs;Exposure to;Funding;Gene Expression;Genetic;Genomics;Goals;Growth;Health;Health and Retirement Study;Heterogeneity;Hospitals;Hybrids;innovation;International;Link;Longitudinal Studies;Measures;Mediating;meetings;member;Meta-Analysis;Methodology;Methods;Modeling;Natural experiment;neuroimaging;Neurosciences;novel;open data;Outcome;Participant;Pathway interactions;Persons;Physicians;Physiological;Process;Professional Organizations;psychologic;psychosocial;Publications;Research Personnel;Research Project Grants;resilience;Sampling;Science;Scientist;Seasons;Services;Social Well-Being;Source;Statistical Methods;statistics;stressor;Surveys;Techniques;Testing;tool;Unemployment;United States National Institutes of Health;virtual;Weight

PROJECT_TITLE: Core C -- Statistics Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

PROJECT_TERMS: Acute;acute stress;Adult;African American population;Age;age related changes;aged;aging process;Alcohols;Alzheimer's disease related dementia;Anger;Anxiety;Behavior;Behavior assessment;Behavioral;behavioral health;Biological Markers;Body mass index;caregiving;Childhood;Chronic;Chronic stress;cohesion;cohort;Cohort Studies;Conflict (Psychology);COVID-19 pandemic;Data;Data Collection;digital technology;disability;Disadvantaged;Discrimination;Disparity population;drinking;Drug usage;early onset;Eating;Education;Emotions;Employment;Ethnic Origin;Event;Exercise;experience;Family;Financial Hardship;follow-up;Friends;Functional impairment;Funding;Goals;Grant;Health;health assessment;Health behavior;health disparity;health inequalities;healthy aging;Impaired cognition;Income;Individual;Inequality;Institution;Interview;Job loss;Life;Life Cycle Stages;Life Stress;Link;long term COVID-19 pandemic impacts;loved ones;low socioeconomic status;Measures;Mediating;Mediator;Mental Depression;Mental Health;middle age;mortality;mortality risk;Multiple Birth Offspring;Neurotic Disorders;Occupational Status;Outcome;pandemic disease;Pathway interactions;peer;perceived discrimination;Personal Satisfaction;Personality;Personality Assessment;Pharmaceutical Preparations;physical conditioning;physical symptom;poor health outcome;Population;positive emotional state;Poverty;Productivity;protective factors;Protocols documentation;psychologic;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Publications;Questionnaires;Race;Recurrence;Relative Risks;Reporting;Research;resilience;Resources;Respondent;retention rate;Review Literature;Risk;Risk Factors;sample collection;Sampling;Science;Self Administration;Smoking;social;Social Distance;social engagement;Social isolation;Social support;social vulnerability;sociodemographics;socioeconomic disparity;socioeconomics;Source;Spirituality;Spouses;Stress;stressor;Surveys;Symptoms;Telephone;Testing;Time;Twin Multiple Birth;Unemployment;Virus;volunteer;Work

PROJECT_TITLE: Project 1 -- MIDUS Survey Project


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Adult;Affect;Age;allostatic load;Alzheimer's disease related dementia;Behavioral;Biological;Biological Markers;Black race;Brain;cardiovascular risk factor;caregiving;Characteristics;Cognitive;cognitive performance;Collection;Complex;COVID-19;Data;Data Collection;Dementia;design;diaries;Diurnal Rhythm;Economic Recession;Economics;Emotional;Epigenetic Process;experience;follow-up;Frequencies;Functional impairment;Future;Gene Expression;Gene Expression Profile;Genomics;Health;health disparity;Health Status;human old age (65+);Hydrocortisone;Impaired cognition;Impairment;individual variation;Inflammation;Inflammatory;innovation;late life;Life Cycle Stages;Link;Long-Term Effects;Measurement;Measures;Mental Health;middle age;Neurosciences;Neurosecretory Systems;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;Performance;Personal Satisfaction;Personality;Persons;physical conditioning;physical symptom;Physiological;Process;Protocols documentation;Psychosocial Factor;Publications;racial disparity;racial prejudice;Recovery;Regulation;Retirement;Role;Saliva;Salivary;smartphone based assessment;Social Change;sociodemographic factors;sociodemographics;Stress;stressor;Surveys;Tablet Computer;Tablets;Technology;Telephone;Testing;Time;Uncertainty;Widowhood;Work

PROJECT_TITLE: Project 2 -- MIDUS Daily Diary Project


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative   The creation of a spatially anchored atlas of the kidney is relevant to public health because the state-of-the art interrogation of human biopsies is ultimately expected to provide novel and rational targets for therapeutic interventions in acute and chronic kidney disease. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing knowledge that will help to reduce the burden of human disease and improve people’s health and quality of life.

PI_NAMEs: ASHKAR, TAREK MAURICE;DAGHER, PIERRE C (contact);EADON, MICHAEL THOMAS

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 3-Dimensional;Acute;Acute Renal Failure with Renal Papillary Necrosis;Atlases;Biological Markers;Biopsy;Biopsy Specimen;Cell Communication;cell type;Cells;Cellular biology;Chronic Kidney Failure;Clinical;cohort;Core Biopsy;Cytometry;Detection;Development;digital pathology;Disease;disease phenotype;Disease Progression;Endothelial Cells;Epithelial Cells;experience;Fibrosis;Genes;Genetic Transcription;Goals;Health;Health system;Heterogeneity;Histopathology;Human;human disease;Image;Immune;immune activation;immune cell infiltrate;Immunofluorescence Immunologic;improved;In Situ;Incidence;indexing;Individual;Infrastructure;Injury;Injury to Kidney;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Knowledge;Link;Longitudinal cohort;Maps;Microscopy;Mission;Molecular;Molecular Disease;molecular phenotype;Molecular Profiling;Molecular Structure;Morphology;Neighborhoods;Nephrons;novel;novel marker;novel therapeutics;Organ;Outcome;Pathogenesis;Pathology;Pathway interactions;Pattern;Persons;Phase;Phenotype;precision medicine;preclinical study;protein expression;proteomic signature;Proteomics;Public Health;Quality of life;Recommendation;repaired;Research;Resources;single nucleus RNA-sequencing;single-cell RNA sequencing;spatial integration;Specimen;Stromal Cells;Structure;targeted treatment;Technology;Testing;Text;Therapeutic Intervention;Tissues;tool;transcriptomics;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Integrated spatial interrogation of cellular and molecular signatures of human kidney disease


ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE (RELEVANCE) We will elucidate the mechanisms by which DNA breaks suppress proliferation in developing B cells to promote normal development and suppress leukemic initiation. We will also delineate RAG-specific mechanisms that regulate DNA damage responses, which will establish critical insights into immune deficiencies and tumor suppressor pathways in B cells. This work will identify new approaches for engineering cellular responses to DNA injury and will reveal new therapeutic opportunities for B cell leukemia.

PI_NAMEs: BEDNARSKI, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Antigen Receptors;Automobile Driving;B cell differentiation;B Cell Proliferation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Cell Leukemia;B-Lymphocytes;Binding;Cell Cycle;Cell Cycle Arrest;Cell Maturation;cell type;Cells;cellular engineering;Clonal Expansion;Complex;Critical Pathways;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Integration;endonuclease;Ensure;Family;Feedback;G1 Arrest;Gene Expression;Generations;Genes;Genetic Recombination;Genetic Transcription;Goals;Immune;Immunity;immunodeficiency;Immunoglobulin Light Chain Genes;immunoglobulin receptor;innovation;insight;Lead;leukemia;leukemic transformation;leukemogenesis;Light-Chain Immunoglobulins;Lymphocyte;Malignant Neoplasms;Mediating;Modeling;Mus;N-terminal;novel;novel strategies;novel therapeutics;Pathway interactions;Phosphotransferases;pre-B cell receptor;prevent;Process;programs;Proliferating;Property;protein complex;Proteins;Receptor Gene;Receptor Signaling;recruit;Regulation;repaired;Reporter;Repression;Repressor Proteins;response;segregation;Signal Pathway;Signal Transduction;Site;SYK gene;System;Testing;TP53 gene;Transcription Coactivator;transcription factor;Transcription Repressor;Tumor Suppressor Proteins;Visualization;Work

PROJECT_TITLE: RAG-mediated DNA Damage Responses in Immune Development and Function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;affective neuroscience;Age;age group;age related changes;Aging;aging population;Alzheimer's disease related dementia;Amyloid beta-42;Amyloid beta-Protein;Behavior;Behavioral;Biological;Biological Factors;Biological Markers;Biology;biopsychosocial;Cardiovascular system;Chronic;Chronic stress;Clinic Visits;clinically significant;Cognitive;cognitive testing;cohort;Collection;Communities;comparative;Conflict (Psychology);COVID-19 pandemic;Data;Data Collection;design;Disadvantaged;Disease;experience;Exposure to;follow-up;functional decline;Functional impairment;Genomics;glucose metabolism;Goals;Health;health disparity;Health Status;Hearing Tests;human old age (65+);Income;Individual;Inflammation;Inflammatory;innovation;late life;Light;Link;Measures;Mediating;Mediator;Mental Health;middle age;Musculoskeletal;neurofilament;Neurosciences;Neurosecretory Systems;Outcome;Participant;Pathway interactions;Pattern;Persons;Physiological;Play;population based;Process;prospective;psychosocial;Psychosocial Factor;psychosocial resources;Publications;Race;racial disparity;Regulation;Research Design;Risk;Role;Sampling;Scientific Advances and Accomplishments;sex;social;social integration;Social support;sociodemographic factors;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Stress;Surveys;System;tau-1;Testing;Time;Treatment/Psychosocial Effects;Twin Multiple Birth;Visit;Well in self;Work

PROJECT_TITLE: Project 3 -- MIDUS Biomarker Project


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurodegenerative;Prevention;Social Determinants of Health

PROJECT_TERMS: accelerated epigenetic aging;Affect;Age;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;American;analytical tool;Biological;Biological Aging;Biological Markers;Biological Process;Biology;biopsychosocial;Blood specimen;Buffers;Cognitive aging;cohort;Communities;Cross-Sectional Studies;Data;Data Collection;design;Disadvantaged;disorder risk;DNA;DNA Methylation;Elements;Epigenetic age;Epigenetic Process;functional genomics;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic information;Genetic Polymorphism;genetic risk factor;Genetic Transcription;genetic variant;genome resource;genome-wide;genomic data;Genomics;Genotype;Health;Human;Individual;Individual Differences;Inflammatory;Leukocytes;Life;Link;Longitudinal Studies;Measures;Mediating;Mediator;Methodology;middle age;Molecular;mortality risk;optimism;Outcome;Participant;Pathway interactions;Pattern;Personal Satisfaction;Personality Character;polygenic risk score;population health;Process;psychologic;psychosocial;Psychosocial Factor;Psychosocial Influences;rate of aging;rate of change;Research;Research Personnel;resilience;resilience factor;Resources;response;Risk;Risk Assessment;Risk Factors;RNA;RNA methylation;Role;Sampling;Single Nucleotide Polymorphism;social;Social support;socioeconomics;Stress;targeted biomarker;Time;Training;transcriptome;Twin Multiple Birth;Venous blood sampling;Viral;Viral Genes;Well in self

PROJECT_TITLE: Project 4 -- MIDUS Genomics Project


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This proposal aims to use leukapheresis product that samples 1-2 L of the blood volume to isolate large number of circulating tumor cells to provide a reliable alternative approach to traditional invasive surgical biopsies. Ultimate goal is to enable detection and tissue localization of early invasive cancers in at-risk individuals.

PI_NAMEs: HABER, DANIEL A.;MAHESWARAN, SHYAMALA ;TONER, MEHMET  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: acquired drug resistance;Active Sites;Address;Antibodies;Biological;Biomedical Engineering;Biopsy;Blood;Blood Cells;Blood Platelets;Blood specimen;Blood Volume;cancer cell;cancer immunotherapy;cancer invasiveness;Cancer Patient;cancer therapy;Cell Separation;Cell Surface Proteins;Cells;Chemotherapy-Oncologic Procedure;Cirrhosis;Clinical;clinical application;clinically relevant;Complex;design;Detection;Diagnostic;diagnostic accuracy;Disease Progression;DNA;Drug Kinetics;Drug resistance;Environmental Risk Factor;Epithelium;Evolution;Excision;experimental study;Explosion;first-in-human;Genetic;Goals;Hereditary Breast Carcinoma;Hour;Human;Immune response;Immunomodulators;Immunotherapy;Individual;innovation;Label;Lesion;Leukapheresis;liquid biopsy;Location;Lung;lung cancer cell;Lung nodule;magnetic beads;Magnetism;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Mesenchymal;Microfluidics;Modality;molecular marker;Monitor;Mononuclear;mouse model;multidisciplinary;multiple omics;neoantigens;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;Patients;Performance;peripheral blood;Persons;Pharmacotherapy;Pilot Projects;Population;pre-clinical;precision oncology;predictive marker;pressure;prevent;Procedures;Property;Proteins;radiological imaging;real time monitoring;Resistance;Resources;response;Risk;RNA;Sampling;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;Smoker;Solid Neoplasm;Sorting;Source;Speed;standard of care;success;targeted treatment;Technology;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Tube;tumor;Tumor Antigens;Tumor Debulking;tumor progression;Tumor-Derived;Validation;validation studies;virtual;Whole Blood

PROJECT_TITLE: Microfluidic sorting of lung cancer cells from leukapheresis product as an alternative to metastatic tumor biopsy


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This proposal is designed to utilize state-of-the-art gene editing technology for knocking out genes that control liver development in the mouse embryo. To replace that liver with one derived from a rat, we will then inject stem cells from a donor rat into the blastocyst of the mouse. This should allow the mouse fetus to grow and function with a new liver that is derived from an entirely different animal species than mouse. These pilot studies are designed to ultimately develop a reproducible and efficient method for generating human livers in pigs for transplantation without the need for immunosuppression; and represent a glimpse into the future of highly individualized medicine.

PI_NAMEs: LOW, WALTER C;STEER, CLIFFORD JOHN (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Ablation;Aging;Alcoholic Liver Diseases;Animal Organ;Animals;Back;Biological;Biological Markers;blastocyst;Cell Differentiation process;cell type;Cells;Chimera organism;chronic liver disease;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;cost effective;CRISPR/Cas technology;design;Development;Developmental Gene;Disease;donor stem cell;Down-Regulation;Education;Embryo;Endoderm;Endothelial Cells;Endothelium;Exhibits;Family suidae;Fetal Development;Fetus;Flow Cytometry;Future;gene editing technology;Gene Expression Profile;Generations;Genes;Genetic Engineering;Genetically Modified Animals;Genomics;Goals;Graft Survival;graft vs host disease;Healthcare;Hematopoiesis;Hematopoietic;Hepatic;Hepatitis;Hepatocyte;Hepatocyte transplantation;high risk;Homeobox;Homeobox Genes;Homologous Transplantation;Human;human embryonic stem cell;human stem cells;Immune;Immune response;Immune system;Immunohistochemistry;Immunologics;Immunology;Immunosuppression;Implant;improved;Incidence;Incubators;Individual;individualized medicine;induced pluripotent stem cell;Injections;innovation;Knock-out;knockout gene;Ligands;Liver;liver development;Liver diseases;liver transplantation;metabolic-associated fatty liver disease;Methods;morphogens;mouse model;Mus;Natural regeneration;nonalcoholic steatohepatitis;novel;offspring;Organ;Organ Donor;organ growth;Organ Transplantation;Pancreas;Patients;permissiveness;Persons;Persuasive Communication;Pilot Projects;Pluripotent Stem Cells;Population;pre-clinical;preimplantation;Process;Production;Property;Protocols documentation;Rattus;receptor;Receptor Cell;Regulation;Reporter;Reproducibility;Research;Resistance;Sheep;single-cell RNA sequencing;Source;stem cells;success;Systems Development;Testing;Thymus Gland;Time;Transcript;transcription activator-like effector nucleases;transcriptomics;translational approach;Translations;Transplantation;Visual;Xenograft procedure

PROJECT_TITLE: Generating Exogenic Organs for Transplantation without the Use of Immunosuppression

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

PHR: Project Narrative Lower respiratory tract infection (LRTI) is a common reason for antibacterial use and overuse globally. The objective of this proposal is to develop and evaluate an evidence-based, cost-effective strategy to improve antibacterial use for LRTI in a low-resource setting. The long-term goal of this work is to translate these methods to other low-resource settings to combat the growing global crisis of antimicrobial resistance.

PI_NAMEs: TILLEKERATNE, GAYANI  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: adjudication;Admission activity;Adult;algorithm development;Algorithms;Anti-Bacterial Agents;Antibiotics;Antimicrobial Resistance;Bacterial Drug Resistance;Bacterial Infections;biobank;Biological Markers;C-reactive protein;Caring;Categories;Cessation of life;Child;Clinical;clinical implementation;clinical outcome assessment;clinical predictors;clinical risk;Clinical Trials Design;Cluster randomized trial;cohort;combat;Communication Methods;cost;cost effective;Country;COVID-19 incidence;COVID-19 pandemic;Data;Decision Trees;design;Development;Diagnostic;diagnostic algorithm;Diagnostic tests;diagnostic tool;Enrollment;epidemiologic data;Etiology;Evaluation;evidence base;Exclusion;Focus Groups;Fright;Goals;hospital bed;Hospitalization;Hospitalized Child;Hospitals;implementation barriers;improved;Income;Infection;infection management;Influenza;Infrastructure;innovation;Intervention;Laboratories;Leadership;Lower Respiratory Tract Infection;Mentored Patient-Oriented Research Career Development Award;Methods;Modeling;novel;Outcome;participant enrollment;pathogen;Patient Admission;Patients;Physicians;point of care;point of care testing;point-of-care diagnostics;Probability;procalcitonin;prototype;Randomized;Randomized, Controlled Trials;Research;Resource-limited setting;response;Risk;Sampling;Sri Lanka;superinfection;System;Teaching Hospitals;Testing;Time Study;Translating;treatment as usual;trial design;Viral;ward;Work

PROJECT_TITLE: A randomized controlled trial of a novel, evidence-based algorithm for managing lower respiratory tract infection in a resource-limited setting

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  The vector-borne spirochetes that cause relapsing fever are transmitted to humans by either ticks or human body lice, and although the etiological agents of relapsing fever were identified over 100 years ago, very little information exists regarding the pathogenic strategies employed by these bacteria. We will gain critical knowledge regarding the regulatory networks that control adaptation of tickborne relapsing fever spirochetes during transmission and infection and identify virulence determinants required by the bacteria for host-pathogen and vector-pathogen interactions. Regulators and virulence factors identified in this project represent potential targets against which future therapeutic interventions and/or diagnostics for tickborne relapsing fever could be developed.

PI_NAMEs: BLEVINS, JON SCOTT (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affinity;Applications Grants;Area;Argasidae;Arthropod Vectors;Arthropods;Bacteria;beta-Lactams;Binding Proteins;Biological Assay;Bite;Borrelia;Borrelia burgdorferi;Borrelia turicatae;cDNA Library;Cell Physiology;Data;Defect;Developing Countries;Diagnostic;Dinucleoside Phosphates;Disease;Elements;Environment;Environmental Impact;environmental stressor;enzootic;Enzymes;Etiology;Future;Gene Expression;Genes;Genetic;Genetic Transcription;genome sequencing;Global Change;Gram-Positive Bacteria;Growth;Heat-Shock Response;High-Throughput Nucleotide Sequencing;Human;Human body;Hydrolysis;In Vitro;Individual;Infection;insight;Ixodes;Knowledge;Life Cycle Stages;Lyme Disease;Mass Spectrum Analysis;Measures;Mediating;Modeling;Molecular;Morphology;Mus;Mutagenesis;mutant;Mutation;neglect;Nutrient;Nutrient availability;Order Spirochaetales;Ornithodoros;Osmosis;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Pediculus humanus humanus;Periodicity;Phenotype;Physiological;Physiology;Play;Poison;Post-Transcriptional Regulation;Production;promoter;Proteins;Proteome;Reactive Oxygen Species;Regulation;Regulon;Relapsing Fever;relapsing fever borrelia;response;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;small molecule;Stress;Suppressor Mutations;System;Testing;Therapeutic Intervention;Tick-Borne Relapsing Fever;Ticks;transcriptome;transcriptome sequencing;transmission process;vector;vector tick;vector-borne;Virulence;Virulence Factors;whole genome;Work

PROJECT_TITLE: Cyclic di-AMP-dependent signaling in tickborne relapsing fever Borrelia

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative To advance public and population health (PPH) within the U.S. healthcare system, we seek to continue training researchers in PPH informatics through an institutional educational program offered by the Regenstrief Institute, Indiana University (IU) Fairbanks School of Public Health, and IU School of Medicine. The program leverages our institutions’ unparalleled population-level data and information systems, close working relationships with multiple innovative health systems, and advanced data science approaches to train the next generation of pioneering PPH informatics researchers, faculty, and leaders.

PI_NAMEs: DIXON, BRIAN E. (contact);SCHLEYER, TITUS K.

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Area;biomedical informatics;Biometry;Caliber;career;Caring;Clinical Informatics;Data Analytics;Data Science;Discipline;Doctor of Philosophy;doctoral student;Education;Epidemiology;Ethnic Origin;experience;Faculty;faculty mentor;Funding;Goals;Health;health data;health management;Health Policy;HIV;improved;Indiana;informatics training;Information Sciences;Infrastructure;Institution;Knowledge;Master of Science;meetings;Mentorship;Methods;Minor;Modernization;next generation;Persons;Population;population health;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Public Health Informatics;Publications;Race;recruit;Research;Research Personnel;Research Project Grants;Scientist;skills;Students;success;Training;Training Programs

PROJECT_TITLE: The Indiana Training Program in Public & Population Health Informatics


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed study aims to solve critical limitations of adoptive cell therapy of cancer by facilitating the development and evaluation of “off-the-shelf” engineered anti-tumor T-cells that will a) resist host immune rejection and b) withstand the immunosuppressive microenvironment of solid tumors. In the F99 phase, I will modify therapeutic T-cells to selectively recognize and eliminate alloreactive lymphocytes via an alloimmune defense receptor (ADR), and in the K00 phase I will identify key changes in tumor microenvironment in response to T-cell activity to further engineer therapeutic T-cells for optimal performance in solid tumors. Successful completion of this proposal will inform the development of next-generation banked T-cell therapies that are safe and effective in cancer patients.

PI_NAMEs: MO, FEIYAN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Ablation;Acceleration;Address;Adoptive Cell Transfers;Adoptive Transfer;Affect;Allogenic;Antibodies;arm;Autologous;Cancer Patient;cancer therapy;CAR T cell therapy;CD19 gene;Cell Therapy;Cells;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinical;Clinical Research;clinical translation;Complex;cost;cytokine;Development;Dose;engineered T cells;Engineering;Evaluation;exhaust;Genetic;Goals;Hematologic Neoplasms;Hematology;Immune;Immune Evasion;Immune system;Immunosuppression;Impairment;improved;individual patient;Inflammation;inflammatory milieu;inhibitor;Knowledge;Liquid substance;Lymphocyte;Macrophage;Malignant Neoplasms;manufacture;Mediating;Mediator;Modification;Molecular;mouse model;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;Neuroblastoma;next generation;OX40;Patients;Peptides;Performance;Phase;post-doctoral training;Postdoctoral Fellow;Pre-Clinical Model;preclinical study;prevent;Primary Neoplasm;receptor;Research;Research Project Grants;Resistance;response;Rest;Reverse engineering;Risk;Site;Solid;Solid Neoplasm;Study models;Surface;T cell therapy;T-Lymphocyte;Therapeutic;TNFSF5 gene;Treatment Efficacy;Treatment outcome;tumor;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions

PROJECT_TITLE: Improving the Efficacy of Allogeneic Cell Therapies of Cancer


ORG_CITY: RICHMOND

ORG_DEPT: CHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Peripheral membrane proteins are highly important mediators of biology and disease, but have proven difficult to study and are a challenge for drug development. We will focus on creating new tools to better understand and to enable inhibition for this class of proteins. Using these original tools, we will gain key insight into how these proteins function and will embark on an innovative approach to develop inhibitors and drug leads.

PI_NAMEs: FUGLESTAD, BRIAN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TITLE: Peripheral membrane proteins and disease: tool development, basic investigations, and inhibitor design


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: NARRATIVE There are major challenges facing the nephrology community in the United States: the overall decrease in interest in nephrology as a specialty and the decreased interest in a career as physician scientist. Therefore, implementation of programs at earlier stages of training in areas where the interest in academic medicine is diminishing is a priority. The goal of this proposal is to engage first year medical students across the Florida state in a summer program designed to foster interest in nephrology by exposing students to basic, clinical, and translational science research opportunities.

PI_NAMEs: FORNONI, ALESSIA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Advisory Committees;American;Area;Basic Science;career;Career Choice;Certification;Clinical Research;Clinical Sciences;Communities;Dedications;design;Educational Curriculum;empowerment;Event;experience;experimental study;Florida;Fostering;Goals;Grant;innovation;Institution;interest;Journals;Kidney;lectures;Medical Education;medical schools;medical specialties;Medical Students;Medicine;meetings;member;Mentors;Names;Nephrology;Outcome;Physicians;programs;Research;Research Activity;Research Project Grants;Schools;Scientist;student participation;Students;summer program;summer research;Supervision;symposium;Training;Translational Research;United States;Universities

PROJECT_TITLE: University of Miami kidney Innovative & Interdisciplinary Medical Education in Research Activities (UM-KIIMERA)


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: GENKINGER, JEANINE M.;SHIMBO, DAICHI  (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Benchmarking;big-data science;career;career development;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;clinically relevant;Collaborations;Communities;curriculum development;Dentistry;design;Development;Discipline;Discipline of Nursing;Disease;Education;Effectiveness;effectiveness evaluation;Engineering;Entrepreneurship;Evaluation;Exposure to;Faculty;Funding;Goals;Grant;Health Professional;implementation science;improved;Individual;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Knowledge;Lead;Medical center;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;multidisciplinary;National Center for Advancing Translational Sciences;National Center for Research Resources;National Research Service Awards;next generation;novel;Operative Surgical Procedures;patient oriented research;Patients;precision medicine;prevent;Prevention;professor;Program Development;Program Effectiveness;programs;Psychiatry;Public Health;recruit;Research;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;Scholars Program;Schools;Science;Scientist;skills;summer research;Teacher Professional Development;TNFSF15 gene;Training;Training Programs;Translating;Translational Research;Universities;Workforce Development

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Bioengineering;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The composition and concentration of proteins in a cell are tightly regulated to maintain cell identity and ensure physiological functions. We propose to apply stable isotope labeling, mass spectrometry, and kinetic modeling methods to understand how the processes of protein synthesis and degradation are orchestrated during cell state transitions in human induced pluripotent stem cell differentiation into various cell types. The resulting knowledge, data, and software tools have the potential to advance current understanding of cellular differentiation and open new avenues for disease modeling and tissue engineering applications.

PI_NAMEs: LAU, EDWARD  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Animal Model;Area;Biological;Cardiac Myocytes;Cell Differentiation process;cell type;Cells;Data Set;data tools;density;Deuterium;Deuterium Oxide;Disease;Disease Marker;disease model;dynamic system;Ensure;Event;experimental study;Hepatocyte;Human;human induced pluripotent stem cells;Investigation;kinetic model;Kinetics;Knowledge;knowledge of results;Maps;Mass Spectrum Analysis;Methods;Modeling;Molecular;nerve stem cell;novel;Physiological;pluripotent stem cell differentiation;Process;Production;Protein Biosynthesis;protein degradation;Proteins;Proteome;Research;Software Tools;Stable Isotope Labeling;success;Techniques;Tissue Engineering;Transcript

PROJECT_TITLE: Investigations of proteome turnover kinetics under cellular differentiation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alcohol-associated liver disease is a pressing public health problem and accounts for increasing mortality due to cirrhosis in the United States. Effective and safe treatments for alcohol-associated liver disease are severely lacking. This project proposes a new paradigm of pathogenesis in alcohol-associated liver disease with the possibility for novel therapies.

PI_NAMEs: MCCONNELL, MATTHEW JOSEPH (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acetaldehyde;acute liver injury;Adhesions;Affect;alcohol abuse therapy;alcohol consequences;alcohol exposure;alcohol response;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Antibodies;Biochemical;Bioinformatics;Biological Process;Biology;Blood Platelets;Blood Vessels;Bone Marrow;career;Cell Communication;Cell Physiology;Cirrhosis;Clinical;Collagen;Cytometry;Data;education resources;Electron Microscopy;Endothelial Cells;Endothelium;experimental study;Fibrinogen;Functional disorder;Generations;Goals;Hepatitis;Image;In Vitro;in vivo;Inflammation;Inflammatory;insight;Integrins;intrahepatic;Liver;Liver diseases;Liver Fibrosis;liver inflammation;Liver Regeneration;Mediating;Mentorship;Microvascular Dysfunction;Mitochondria;Molecular;mortality;multiple omics;Mus;new therapeutic target;novel therapeutics;Outcome;Oxidative Stress;particle;Pathogenesis;Pathologic;Patients;Pharmacotherapy;Phenotype;Platelet Activation;Platelet aggregation;platelet phenotype;Play;Portal Hypertension;Pre-Clinical Model;problem drinker;Process;Proteome;Public Health;Publishing;Research;response;Role;Sampling;targeted treatment;Testing;Therapeutic Effect;Thrombosis;transcriptome;transcriptome sequencing;transcriptomic profiling;United States;Universities;Up-Regulation;vascular inflammation;Visualization

PROJECT_TITLE: The role of platelets in the pathogenesis of alcohol-associated liver disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE: Opioid use disorder most commonly begins during adolescence and young adulthood and requires early intervention to prevent lifetime harms. This project will use Medicaid data from across the US and apply a novel analytic framework, the Cascade of Care, to the care of youth aged 13-25 with opioid use disorder. Researchers will identify racial and ethnic disparities in key stages of the Cascade of Care (diagnosis, treatment initiation, medication receipt, short-term engagement, and long-term retention), examine the role of medications in promoting treatment engagement and retention in youth of color, and measure real-world health outcomes in youth who fall out of treatment.

PI_NAMEs: HADLAND, SCOTT EVAN (contact);WILLIAMS, ARTHUR R

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Acceleration;Accident and Emergency department;addiction;Adolescence;Adolescent and Young Adult;Adopted;Adult;adverse outcome;Age;age group;aged;Black race;Buprenorphine;Caring;children of color;Chronic Disease;Climate;Clinical;clinical care;community engagement;Continuity of Patient Care;County;Data;Databases;Diagnosis;Disparity;Drug abuse;Early Intervention;Enrollment;Ensure;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;experience;falls;Family;Future;Generations;Geographic Locations;Goals;Health;health disparity;health equity;Health Services Research;Healthcare Systems;HIV;Hospitalization;Hospitals;Imprisonment;improved;Individual;Inequity;Information Systems;Inpatients;Insurance Carriers;interest;Intervention;Lead;Legal;Life Cycle Stages;Link;Longitudinal Studies;Measures;Medicaid;medication for opioid use disorder;Methadone;minority children;Modeling;Morbidity - disease rate;mortality;Naltrexone;Not Hispanic or Latino;novel;operation;opioid misuse;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;Pharmaceutical Preparations;Pharmacy facility;Policies;Population;prevent;primary outcome;programs;protocol development;Quality of Care;Race;racial disparity;racial minority;Research;Research Personnel;Role;secondary outcome;Series;Services;social;substance use;treatment disparity;Unemployment;US State;Work;World Health;young adult;Youth

PROJECT_TITLE: Identifying Disparities in the Cascade of Care for Medicaid-Enrolled Youth with Opioid Use Disorder


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health;Stroke;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Extreme weather events such as wildfires and prolonged drought in the last decade alone have adversely affected air pollution exposure in states such as California, resulting in a number of metropolitan counties with particulate pollution levels above federal and state ambient standards and levels that rival the world's most polluted cities during large wildfires. In this application, we will leverage 25 years of follow-up in the California Teachers Study cohort to evaluate the intersection of severe weather events and air pollution in an aging female population who are at their peak susceptibility for stroke and other cardiovascular diseases.

PI_NAMEs: FRANKLIN, MEREDITH ;WANG, SOPHIA S. (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Adult;Affect;Age;Aging;Air Pollutants;Air Pollution;Area;biobank;Biological;Biomass;Blood;Burn injury;California;Carbon;Carbon Dioxide;Cardiovascular Diseases;cardiovascular disorder risk;Chemicals;Cities;Cohort Studies;County;critical period;Data;Diameter;Diesel Fuels;disability;Disasters;Disease;Disease susceptibility;Droughts;Elements;Emergency department visit;Energy-Generating Resources;Environment;Environmental Policy;Evaluation;Event;Exposure to;extreme weather;Female;fine particles;Fire - disasters;follow-up;Gases;Geography;Health;Home;Hospitalization;human old age (65+);Imagery;Immune;Immune response;Immune Sera;Immunologic Markers;Industrialization;Inflammation;Inflammatory;Link;Maps;Measurable;Measures;men;Menopause;Metals;meter;metropolitan;Modeling;mortality;Myocardial Infarction;Nitrates;Nitrogen Dioxide;older adult;older women;Participant;particle;Particulate;Particulate Matter;Pathogenesis;Pathway interactions;Persons;Pollution;Population;population based;Postmenopause;Predisposition;Production;Publications;Recording of previous events;Regulatory T-Lymphocyte;Reporting;response;Risk;Role;Seasons;severe weather;Source;Stroke;stroke event;stroke risk;study population;Sulfate;systemic inflammatory response;teacher;Time;Transportation;Vulnerable Populations;Wildfire;Woman;Women's Health

PROJECT_TITLE: Extreme weather, air pollution, and stroke among an aging female population

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: RELEVANCE (See instructions): DNA sequencing is used to profile the amount of different bacteria or the expression of different genes within an organism. Yet limitations of the measurement process (e.g., measurement bias) restrict our ability to use this data. This work will develop new statistical methods which enable scientists to account for these data limitations and therefore to increase our understanding of human health and disease.

PI_NAMEs: SILVERMAN, JUSTIN D (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Bacteria;biological systems;Biomedical Research;Case Study;computer framework;Computer software;computerized tools;Data;Data Analyses;Disease;DNA sequencing;Experimental Designs;Genes;Health;Human;Instruction;Light;Measurement;Measures;Methods;Modeling;Modernization;National Institute of General Medical Sciences;Noise;Organism;Persons;Process;Reproducibility;Research Design;Scientist;Sequence Analysis;single-cell RNA sequencing;Statistical Methods;stem;System;theories;tool;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: DMS/NIGMS 1: Addressing Measurement Limitations for Sequence Count Data


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The interplay between anti-phage defense systems in bacteria and counter-defense strategies in phages can determine phage infection outcomes, which in turn have widespread impacts on the evolution and treatment of infectious disease. Most defense and counter-defense systems in nature have not been identified, so we will apply a novel functional selection scheme to identify these systems from various metagenomes and libraries of synthesized phage genes. We will then use genetic and functional techniques to characterize these systems mechanistically and reveal fundamental insights into the molecular arms race between bacteria and phage.

PI_NAMEs: FORSBERG, KEVIN J (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adsorption;Antibiotic Resistance;Antibiotics;arms race;Bacteria;Bacterial Infections;Bacteriophage lambda;Bacteriophages;Basic Science;Biological Assay;Biology;Cell Survival;conventional therapy;CRISPR/Cas technology;Data;Databases;Drug resistance;Ecosystem;Escherichia coli;Evolution;flexibility;gain of function;Genes;Genetic;Genome;Genomic Islands;Genomics;Horizontal Gene Transfer;Human;Human Microbiome;human pathogen;Immune;Immunity;Infection;infectious disease treatment;inhibitor;insight;Knowledge;Libraries;Link;metagenome;Metagenomics;Methods;microbial;Modification;Molecular;molecular array;Multi-Drug Resistance;Mutation;Nature;novel;novel strategies;Open Reading Frames;Outcome;pathogen;Pathogenesis;Phenotype;Plasmids;Prophages;Proteins;receptor;Resistance;resistance gene;Resources;response;Scheme;Source;success;Surveys;System;Techniques;Testing;Therapeutic;Time;Toxin;Virulence;Virulence Factors

PROJECT_TITLE: Discovery of bacterial defense and phage counter-defense strategies


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_STATE: CA

PHR: PROJECT NARRATIVE The 5-year survival rate for patients diagnosed with the blood cancer acute myeloid leukemia (AML) is 27.4% and the median survival for relapsed elderly patients is less than 7 months despite significant advances in care. We have developed an immunotherapy that genetically engineers human T cells to target a protein called FLT3 on leukemia cells. Upon conclusion of these studies of this FLT3 immunotherapy T cell drug, we will better understand how to treat AML and be poised to start a therapy directed at curing a greater fraction of AML patients.

PI_NAMEs: BUDDE, LIHUA ELIZABETH;CALIGIURI, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;Allogenic;Antigen Targeting;Antigens;antileukemic activity;B lymphoid malignancy;B-Cell Lymphomas;Back;Biological;Blood;Bone Marrow;CAR T cell therapy;Caring;CD19 gene;Cell Line;Cell surface;Cell Therapy;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;clinically relevant;Correlative Study;cytotoxic;cytotoxicity;Data;Databases;density;design;Diagnosis;Disease;Dose;early phase clinical trial;effective therapy;Effectiveness;Effector Cell;Eligibility Determination;engineered T cells;Engraftment;experience;experimental study;FDA approved;FLT3 gene;FLT3 inhibitor;Genetic Engineering;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Human;Human Engineering;Immune;Immune system;immunoregulation;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Infusion procedures;innovation;insight;Institutional Review Boards;Interleukin-15;interleukin-15 receptor;Leukemic Cell;leukemic stem cell;manufacture;Methodology;Morbidity - disease rate;mortality;mouse model;Mus;mutational status;Myelogenous;Natural Killer Cells;neoplastic cell;nonhuman primate;novel;older patient;overexpression;participant enrollment;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;phase 1 study;Phase I Clinical Trials;Physicians;Population;pre-clinical;preclinical study;Procedures;Process;programs;Proteins;receptor;receptor expression;Receptor Protein-Tyrosine Kinases;Refractory;Relapse;Reporting;Safety;Scientist;sound;stem cell function;success;Surface;Surface Antigens;Survival Rate;T cell therapy;T-Lymphocyte;Therapeutic Intervention;timeline;Toxic effect;transduction efficiency;translational physician;Tyrosine Kinase Inhibitor;Umbilical Cord Blood;Xenograft procedure

PROJECT_TITLE: Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE The percentage of underrepresented minorities in the biomedical careers is below the corresponding percentage for majority groups. The primary emphasis of Project ACE -- ACtion for Equity: A BUILDing SCHOLARS Pipeline is to increase the number of underrepresented students from historically and economically disadvantaged backgrounds in the biomedical fields through instruction based on a research- infused curriculum. By exposing students to biomedical research at the high school level; incorporating their teachers in research experiences; and engaging students' families in their academic and research skills growth, Project ACE will create a pipeline of Hispanic students from economically disadvantaged high schools who are prepared academically and socially to pursue biomedical careers.

PI_NAMEs: BOLAND, THOMAS ;MORERA, OSVALDO F (contact);TINAJERO, JOSEFINA V

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academic achievement;academic preparation;Active Learning;Area;Behavioral Research;Behavioral Sciences;Biomedical Research;career;career awareness;Clinical Research;Clinical Sciences;college;College Preparation;curriculum enhancement;Development;disadvantaged background;Disadvantaged minority;disadvantaged student;economic disparity;Education;Educational Curriculum;Educational process of instructing;Educational workshop;eighth grade;Endowment;Engineering;English Learner;Environment;Equity;expectation;experience;Exposure to;Faculty;Family;Fellowship Program;Fostering;Funding;Goals;graduate student;Grant;Growth;Health;high school;High School Faculty;High School Student;Hispanic;improved;Infrastructure;innovation;Instruction;interest;Laboratories;Learning;Literature;Mathematics;member;Mentors;Mentorship;neighborhood disadvantage;New Mexico;Outcome;peer coaching;Performance;Preparation;programs;Readiness;Research;Research Activity;research and development;Resources;role model;Scholarship;Science;science teacher;Self Efficacy;skills;social;Socialization;student participation;Students;summer research;symposium;Talents;teacher;Technology;Texas;Training Programs;tutoring;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;Work;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Narrative The objective of this training program is to offer an integrative curriculum and environment needed to train the next generation of thought leaders and workforce that are versed in convergence research leading to regenerative engineering solutions for adult and pediatric patients with major disabilities. Specifically, program graduates will have the capacity to develop scientific, technical, and clinical knowledge and skills that will enable them to recognize and solve challenges associated with the restoration of tissue and organ function. Core innovative and unique elements of the program include: 1) clinical rotations to gain direct insight into organ failure and tissue reconstruction challenges that afflict patients and physicians; 2) a 3-member mentorship team that includes 1 clinical, 1 life/physical sciences, and 1 engineering faculty member; 3) internships at companies and/or institutions with product development expertise involving regenerative engineering; and 4) experiential courses to learn experimental techniques that are essential to the implementation of regenerative engineering.

PI_NAMEs: AMEER, GUILLERMO ANTONIO (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TITLE: Regenerative Engineering Training Program (RE-Training)