NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: OAKLAND

ORG_NAME: MINUTIA, INC.

PHR: Project Narrative Failure of donor islet engraftment in patients living with type 1 diabetes (T1D) occurs due to challenges in the transplant niche including inflammatory stress that follows an immune assault to the allogeneic cell graft. Developing technologies that could identify such adverse events non-invasively and in real time at the site of graft could enable surgical teams to design interventional therapies to halt or reverse damage to the transplanted material, changing the landscape of allogeneic cell therapy. Our proposal describes a novel strategy to monitor intracellular responses to inflammation in insulin-producing cells that will have direct implications for long-term survival and proper function of islet grafts, leading to sustained insulin independence for patients with T1D.

PI_NAMEs: DIGOVICH, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: 3-Dimensional;Acute;Adaptive Immune System;Address;Adverse event;Allogenic;Animal Model;Anti-Inflammatory Agents;assault;autoimmune pathogenesis;Beta Cell;Binding;Biology;Biosensing Techniques;Biosensor;Black Box;Blood Glucose;C-Peptide;cell replacement therapy;Cell Surface Proteins;Cell Therapy;Cell Transplantation;cell type;Cells;Clinical;cohort;commercialization;cyanine dye 5;cytokine;Cytoprotection;design;detection platform;Development;Diabetes Mellitus;Engraftment;Environment;experience;Failure;Feedback;Future;Goals;Health;human stem cells;Immune;immune activation;Immune system;Immunosuppression;improved;improved outcome;In Vitro;in vivo;in vivo monitoring;Infection;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Innate Immune System;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Islets of Langerhans Transplantation;Lead;lead candidate;Learning;Location;manufacture;Measurable;Measures;Methodology;Methods;MicroRNAs;Mission;Monitor;nanoengineering;nanoparticle;nanoprobe;nanosensors;novel;novel strategies;Operative Surgical Procedures;Organ;Organ Transplantation;Organoids;Patients;Phase;Physiological;post-transplant;Pre-Clinical Model;Procedures;Process;replacement tissue;Resources;response;scale up;sensor;Signal Induction;Signal Transduction;Site;Small Business Innovation Research Grant;stem cell therapy;stem cells;Stress;subcutaneous;success;System;Technology;Testing;Therapeutic Intervention;therapy design;Time;Tissue Grafts;Tissue Transplantation;tool;Transplantation

PROJECT_TITLE: Monitoring graft responses to the transplant niche in allogeneic cell replacement therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Label-Free Optical Redox Imaging for Pretreatment Prognosis of Early-Stage Triple Negative Breast Cancer Narrative Abnormal metabolism and redox status have been demonstrated in high-risk breast cancer. Using clinical specimens, mouse xenografts, and cell models, we will validate an optical redox imaging method to predict the risk of progression in triple negative breast cancer (TNBC). The proposed research is relevant to public health because it will identify clinically translatable novel biomarkers to stratify the progression risk in untreated TNBC patients, supporting the NIH’s mission to improve cancer diagnosis and personalized treatment planning.

PI_NAMEs: LI, LIN Z (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Affect;Archives;Biological Markers;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Risk Factor;cancer diagnosis;Cancer Prognosis;cancer type;Cell Culture Techniques;Cell model;Cell Respiration;Cessation of life;Clinic;Clinical;clinical decision-making;clinical imaging;clinical translation;cohort;Cohort Studies;Cultured Cells;Data;Data Set;Dimensions;Disease;Disease Progression;disorder risk;Exhibits;Flavoproteins;Fluorescence;fluorescence imaging;Freezing;Future;Genetic;Glycolysis;Goals;high risk;Human;Hypoxia;Image;imaging biomarker;imaging modality;imaging study;Imaging Techniques;improved;indexing;Individual;individual patient;innovation;Label;Laboratories;lung metastatic;Malignant Breast Neoplasm;Mammary Neoplasms;Maps;Measures;Metabolic;metabolic imaging;metabolic phenotype;metabolic profile;Metabolism;metabolomics;meter;millimeter;Mission;Molecular;mouse model;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;Nicotinamide adenine dinucleotide;Nodal;novel;novel marker;nutrition;Operative Surgical Procedures;Optics;Outcome;Oxidation-Reduction;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Phenotype;Pilot Projects;Pre-Clinical Model;predict clinical outcome;Prognosis;prognostic indicator;Prognostic Marker;prognostic model;prognostic significance;prognostic value;prognostication;programs;progression risk;Prospective Studies;Public Health;Receiver Operating Characteristics;Recurrence;Research;Resolution;risk prediction;risk stratification;Role;Signal Transduction;Specimen;Stains;Techniques;Testing;Time;tool;Training;treatment optimization;treatment planning;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor metabolism;tumor microenvironment;tumor progression;Tumor Volume;United States National Institutes of Health;Validation;Variant;Vascular blood supply;Warburg Effect;Xenograft Model;Xenograft procedure

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Franklin

ORG_NAME: YAYA SCIENTIFIC, LLC

ORG_STATE: TN

PHR: PROJECT NARRATIVE Unintended nerve damage during surgical procedures is a significant and costly public healthcare delivery problem and current methods for injury prevention via intraoperative nerve monitoring leave substantial room for improvement. The ramifications of increased healthcare costs due to associated medical-liability issues and the significant reductions in quality-of-life issues, including the burgeoning chronic pain management related opioid- related drug overdose epidemic, make addressing this very impactful to society. The proposed development will yield an effective, commercially viable, non-contact multimodality imager that provides realtime intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage during surgical procedures.

PI_NAMEs: BABA, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: absorption;Acceleration;Accidents;Acoustic Neuroma;Address;Algorithmic Software;Award;Biophotonics;Blinded;Breast Cancer Treatment;Cessation of life;Characteristics;Chronic;chronic pain;chronic pain management;Clinical;Clinical Data;clinical implementation;Clinical Research;Compensation;contrast enhanced;cost;Data;data acquisition;Data Analyses;deafness;design;Detection;Development;Devices;Diffuse;diffuse reflectance spectroscopy;efficacy testing;Employment;Epidemic;Excision;Face;Feedback;Femur;Financial cost;first-in-human;flexibility;Future;Generations;Goals;Health Care Costs;health care delivery;Health Personnel;Healthcare;Healthcare Industry;human subject;Hybrids;Iatrogenesis;Image;Image-Guided Surgery;imager;Imaging Device;Impotence;improved;in vivo;Income;Individual;inferior alveolar nerve;Injury;injury prevention;Intellectual Property;Label;Laryngeal Nerves;Legal patent;Lesion;Light;Litigation;Marketing;Mastectomy;Medical;Medical Care Costs;Medical Imaging;Medical Liabilities;men;Methods;Monitor;Morbidity - disease rate;Motor;multimodality;Nerve;nerve damage;nerve injury;Nerve Tissue;neural;novel;Numbness;operation;Operative Surgical Procedures;Opioid;opioid use;Oral Surgical Procedures;Overdose;overdose death;pain outcome;Paraplegia;Patients;Performance;peroneal nerve;Pharmaceutical Preparations;Pharmacotherapy;Phase;Postoperative Pain;Postoperative Period;preclinical study;Prevention;Process;prototype;Provider;Public Health;Quality of life;Radical Prostatectomy;Recurrence;Reporting;Research Design;Rights;Risk;Role;Safety;scoliosis;Secure;Small Business Technology Transfer Research;Societies;software development;software systems;Source;spared nerve;Specificity;spectroscopic imaging;Spinal;Structure of radial nerve;Surgeon;Survivors;System;Techniques;Technology;Testing;Thoracic Surgical Procedures;Thyroid Gland;Thyroidectomy;Time;Tissues;Trigeminal nerve structure;United States;Universities;Update;Ventral thoracic nerve structure;Visualization

PROJECT_TITLE: Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project narrative Despite the success of cochlear implants, devices surgically placed in the inner ears of patients with severe hearing loss, the overall speech perception outcomes vary substantially among the individuals who receive them. The main goals of this project are: i) to produce 3-D maps of cochlear histopathology at the electrode- neuron interface in temporal bones from cochlear implant recipients and relate them to clinical measures and outcomes, ii) to apply that knowledge to develop and validate a computational model of the electrode-neuron interface using histopathology, research and clinical measures, and iii) finally, to improve speech perception scores for cochlear implant listeners by focusing and/or deactivating a subset of channels based on electrode- neuron interface estimates. The results will improve our understanding of the effects of hearing loss and cochlear implantation on the histopathology of the auditory nerve, and the relation of those details to clinical measures, ultimately leading to advances in clinical practice and improving hearing outcomes in cochlear implant listeners.

PI_NAMEs: ARENBERG, JULIE G (contact);QUESNEL, ALICIA M

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 3-Dimensional;Acclimatization;Acoustic Nerve;Action Potentials;Adult;Assessment tool;Audiology;Auditory;Axon;Basic Science;Behavioral;Bone Growth;Child;Chronic;Clinical;clinical care;Clinical Data;clinical practice;clinical predictors;Cochlea;Cochlear implant procedure;Cochlear Implants;Collection;Complex;Computer Models;Data;density;Detection;Devices;Distant;electric field;Electric Stimulation;Electrodes;Environment;Evoked Potentials;experimental study;Foreign Bodies;Goals;Growth;Health;Hearing;hearing impairment;hearing restoration;Histology;Histopathology;Human;Implant;implantation;improved;improved outcome;Individual;insight;Knowledge;Labyrinth;Learning;Machine Learning;Maps;Measures;Methods;Modeling;nerve supply;neural;neural prosthesis;neuronal growth;Neurons;Noise;Operative Surgical Procedures;Outcome;Output;Participant;Pathology;Patients;Pattern;Performance;Peripheral;Physiologic Ossification;Physiologic pulse;Positioning Attribute;programs;reconstruction;Research;response;sound;speech in noise;Speech Perception;spiral ganglion;Stimulus;success;Temporal bone structure;Testing;Time;tool;Translating;translational approach;Trauma;Update;Variant

PROJECT_TITLE: Improving Cochlear Implant Outcomes Through Modeling and Programming Strategies Based on Human Inner Ear Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-A(02)M]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: We have been studying the mechanism by which Canakinumab (an IL-1β blocking antibody) stimulates the immune response to cancer in treated patients. We have discovered that this occurs by blocking the production of immunosuppressive factors by myeloid cells that skew the tumor microenvironment in favor of tumor growth, but also unexpectedly by permitting the immunostimulatory effect of IL-1α on CD8 T cells,. In this proposal, we explore the detailed mechanism of this pathway further, and utilize novel therapeutic compounds to selectively stimulate or block cytokine activity on specific cells, towards the end of designing a definitive immunotherapeutic treatment for cancer.

PI_NAMEs: KUPPER, THOMAS S. (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;anakinra;Animals;anti-cancer;anti-PD1 antibodies;Antibodies;antibody inhibitor;autocrine;Blocking Antibodies;cancer immunotherapy;Cancer Model;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Chronic;Clinical Trials;Combined Modality Therapy;cytokine;Data;Dendritic Cells;design;Development;Disease;Dose;Eye;Future;Gene Expression;Gene Expression Profile;Goals;Heterozygote;Human;IL1R1 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunologic Stimulation;Immunosuppression;Immunotherapeutic agent;improved;in vivo;Incidence;Infiltration;Inflammatory;interest;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Knowledge;Ligands;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Memory;mouse model;Mus;Myelogenous;Myeloid Cell Activation;Myeloid Cells;neutrophil;novel;novel therapeutics;paracrine;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Process;Production;programmed cell death protein 1;programs;promoter;Publishing;Receptor Signaling;Role;Signal Transduction;success;synergism;System;systemic toxicity;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;Therapeutic Uses;Time;Tissues;Toxic effect;trafficking;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Visualization;Work

PROJECT_TITLE: Using the IL-1R1 and its ligands to optimize the T cell immune response to cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: OVERALL COMPONENT: PROJECT NARRATIVE Falls and cognitive impairments are disabling and currently untreatable features of Parkinson disease. University of Michigan scientists developed evidence that falls and cognitive impairments arise from degeneration of brain cells using the chemical messenger acetylcholine. By integrating neuroimaging, behavioral, and physiological studies in patients with Parkinson’s disease and in animal models, we aim to further dissect the relationships between falls, cognitive impairments, and abnormalities of these brain cells.

PI_NAMEs: ALBIN, ROGER L (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;Affect;Animal Model;Anterior;Attention;attentional modulation;basal forebrain;Basal Ganglia;base;Basic Science;Behavioral;Biometry;Brain;brain abnormalities;brain cell;brain dysfunction;career;catalyst;Characteristics;Chemicals;cholinergic;Clinical;Clinical Research;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cohort;Collaborations;Communities;Corpus striatum structure;Data;data management;Denervation;Diffuse;Disabling;Disease;disease heterogeneity;Disease Progression;disorder subtype;dopamine replacement therapy;Electrophysiology (science);equilibration disorder;Equilibrium;Exhibits;experience;falls;Freezing;Functional disorder;Gait;Gait abnormality;Genetic;genetic approach;Goals;Impaired cognition;improved;innovation;insight;Interneurons;Lead;Lesion;Ligands;Link;member;Mentors;Mentorship;Methods;Michigan;Modeling;Modernization;Motor;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neural circuit;neuroimaging;Neurosciences;neurotransmission;next generation;Nodal;novel strategies;optogenetics;outreach;Parkinson Disease;Pathologic;Pathway interactions;Patients;Pattern;Persons;Physiological;Play;Positioning Attribute;Positron-Emission Tomography;Posture;posture instability;Pre-Clinical Model;programs;prospective;prospective test;Rattus;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Rodent Model;Role;Scientist;Sensory;Signal Transduction;Site;Specific qualifier value;Stimulus;System;Testing;Thalamic structure;therapeutic target;therapy resistant;Training;Universities;Visual attention;Visuospatial;Work

PROJECT_TITLE: Cholinergic mechanisms of attentional-motor integration and gait dysfunction in Parkinson Disease


NIH_SPENDING_CATS: Aging;Brain Disorders;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Attention;catalyst;cholinergic;Clinical;Communication;Communities;community building;Community Health Education;Community Outreach;Data;Decision Making;Development;Education;Educational Activities;Ensure;Gait abnormality;Goals;graduate student;interest;Lead;lectures;Link;meetings;member;Mentors;Mentorship;Michigan;Monitor;Motor;National Institute of Neurological Disorders and Stroke;Occupational activity of managing finances;operation;outreach;Parkinson Disease;Participant;Personnel Management;Persons;Policies;Postdoctoral Fellow;repository;Research;Resource Sharing;Resources;Scientific Advances and Accomplishments;Scientist;Supervision;symposium;Training;Universities;web site;Work

PROJECT_TITLE: Core A:  Administrative Core


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pregnancy;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Perinatal depression is the most common complication of pregnancy, leading to impaired health for the individual, family, and community. While the collaborative care model (CCM) has demonstrated efficacy for treatment of depression in primary care, it is rarely utilized in obstetric care due to gaps in effectiveness and implementation outcomes. This rigorous stepped-wedge randomized trial 1) enhances the CCM by embedding a multi-level approach to achieving equity in mental health care, 2) evaluates the effectiveness of the CCM on mental health outcomes, 3) analyzes the impact of the CCM on racial and ethnic health disparities, and 4) optimizes an implementation strategy package via a hybrid type 2 implementation-effectiveness design with the ultimate goal of achieving broad-scale implementation of equity-centered perinatal CCMs within obstetric care sites nationally.

PI_NAMEs: FEINBERG, EMILY ;MILLER, EMILY STINNETT (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;Advocate;Algorithms;anti-racism;Attention;Behavioral;Black race;care coordination;Caring;Clinic;Clinical;Cluster randomized trial;collaborative care;Communities;cost;Data;Databases;depressive symptoms;Diagnosis;Discrimination;Disease remission;Disparity;effectiveness evaluation;effectiveness outcome;effectiveness/implementation design;Equity;ethnic difference;ethnic disparity;ethnic health disparity;Ethnic Origin;Ethnic Population;evidence base;evidence based guidelines;experience;Family;Feeling suicidal;Foundations;Goals;health disparity;health equity;Health system;Hybrids;Impaired health;Impairment;implementation evaluation;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Individual;Inequity;innovation;Intervention;Interview;Latinx;Lead;Left;Major Depressive Disorder;maternal morbidity;Maternal Mortality;Measurement;Mental Depression;Mental Health;Mental Health Services;Modeling;obstetric care;Outcome;patient oriented;Patients;Perinatal;Perinatal Care;perinatal mental health;peripartum depression;personalized care;Persons;Population;population based;post pregnancy;Postpartum Depression;Postpartum Period;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Primary Care;primary care setting;primary outcome;Provider;Psyche structure;Psychiatric therapeutic procedure;Publishing;Quality of life;Race;racial difference;racial disparity;racial health disparity;racial population;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;reducing suicide;Research;research to practice;response;Rhode Island;Risk Factors;Sample Size;screening;Services;severe maternal morbidity;Severities;single episode major depressive disorder;Site;social determinants;standard care;Structural Racism;Structure;study population;success;Suicide;Support Groups;Supportive care;Symptoms;System;Testing;therapy design;treatment as usual;Treatment Efficacy;treatment optimization;United States;Validation;Woman

PROJECT_TITLE: Collaborative Care Model for Perinatal Depression Support Services -- Population-Level Equity-Centered Systems Change (COMPASS-PLUS): A Hybrid Type 2 Cluster Randomized Trial


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Disability Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This research will test several novel hypotheses regarding the interactions between synaptic zinc, glutamate, GABA, NMDA receptors (NMDARs), AMPARs and GABARs. These interactions are fundamental to our understanding of synaptic transmission and synaptic plasticity, as well as sound processing in health and hearing loss. Because these processes are found in many brain areas and are associated with several disorders, such as epilepsy, hyperekplexia, autism, schizophrenia, Alzheimer’s disease, hearing loss, tinnitus and pain processing, this research is relevant to those aspects of the NIH mission aimed at improving health through understanding pathophysiological mechanisms in disorders causing disability.

PI_NAMEs: TZOUNOPOULOS, THANOS  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Nerve;Alzheimer's Disease;Area;auditory rehabilitation;autism spectrum disorder;awake;Behavior;Behavior assessment;Behavioral Assay;Brain;Brain region;Brain Stem;cell type;Cells;Chelating Agents;Cochlear Implants;Detection;Development;disability;Discrimination;Disease;Electrophysiology (science);Environment;Epilepsy;experimental study;flexibility;gamma-Aminobutyric Acid;Genes;Glutamates;Health;Hearing;Hearing Aids;hearing impairment;Human;Hyperacusis;improved;In Vitro;in vivo;in vivo calcium imaging;inducible Cre;Judgment;Knock-out;knockout gene;Knockout Mice;Light;Link;LoxP-flanked allele;Maintenance;Mission;Modality;Mus;N-Methyl-D-Aspartate Receptors;neuroadaptation;Neuromodulator;Neurons;neuroregulation;noise trauma;novel;novel strategies;Outcome;pain processing;Pathologic;Peripheral;pharmacologic;Pharmacotherapy;Process;programs;recombinase;Recovery;Rehabilitation therapy;Research;response;Role;Schizophrenia;Sensory;sensory stimulus;Signal Transduction;SLC30A3 gene;sound;Specificity;statistics;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Tamoxifen;Testing;Time;Tinnitus;tool;Transgenic Mice;United States National Institutes of Health;Zinc;zinc-binding protein

PROJECT_TITLE: Cortical neuromodulatory mechanisms underlying adaptation and plasticity

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: BOHNEN, NICOLAAS IDA (contact)

PROJECT_TERMS: Age;Attention;Biometry;cholinergic;Classification;Clinic;Clinical;Clinical assessments;Clinical Data;Cognition;cohort;Collaborations;Common Data Element;Consensus;Data;Data Analyses;Data Collection;data exchange;data management;Databases;Decision Making;Diagnostic;Eligibility Determination;Enrollment;Evaluation;experience;follow up assessment;follow-up;Fostering;Foundations;Gait abnormality;Gender;Goals;Health Insurance Portability and Accountability Act;human subject;in vivo;Infrastructure;Institutional Review Boards;instrument;Magnetic Resonance;Methods;Michigan;Motor;Movement Disorders;National Institute of Neurological Disorders and Stroke;neuroimaging;Neuropsychology;Newsletter;Online Systems;operation;organizational structure;Parkinson Disease;Patients;Phenotype;Policies;Population;Positron-Emission Tomography;Process;Quality Control;recruit;Registries;Regulation;repository;Research Personnel;Research Subjects;Resolution;Resources;Standardization;symposium;Universities

PROJECT_TITLE: Core B:  Clinical Resource Core


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: KANEL, PRABESH  (contact)

PROJECT_TERMS: acetylcholine transporter;Age;Anatomy;Attention;Biometry;cholinergic;Classification;Clinical;Cognition;Collaborations;Consensus;Data;Data Analyses;data exchange;data management;Diagnostic;diffusion weighted;Disease Progression;dopamine transporter;Eligibility Determination;Ensure;Evaluation;follow-up;Functional Magnetic Resonance Imaging;Gait abnormality;Gender;Goals;human subject;in vivo;Infrastructure;Institutional Review Boards;Ligands;Magnetic Resonance Imaging;Michigan;Motor;multimodal neuroimaging;nerve supply;Netherlands;Network Infrastructure;neuroimaging;Neurosciences;organizational structure;Parkinson Disease;Pathology;Pathway Analysis;Pattern;Physiological;Positron-Emission Tomography;Progressive Supranuclear Palsy;Radiopharmaceuticals;Regulation;Research;Research Personnel;Resources;Rest;Retrieval;Statistical Data Interpretation;symposium;Tomogram;tomography;Universities

PROJECT_TITLE: Core C:  Neuroimaging Resource Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Disability Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: SPINO, CATHERINE A (contact)

PROJECT_TERMS: Adherence;Advocate;analytical method;Anatomy;Attention;Biological Markers;Biometry;Brain imaging;Brain region;catalyst;cholinergic;Clinical;Clinical Research;Cognition;Cognitive;Collaborations;Common Data Element;Communities;Computer Analysis;Computer software;Computing Methodologies;Data;Data Aggregation;Data Analytics;Data Collection;data dashboard;Data Element;Data Files;data harmonization;data infrastructure;data integrity;data management;Data Management Resources;Data Set;data sharing;data standards;Data Storage and Retrieval;data structure;data submission;Databases;Dedications;density;design;Development;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Education;electronic data;Ensure;Evolution;experience;Experimental Designs;Faculty;falls;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Gait;Gait abnormality;Goals;gray matter;Health;heterogenous data;high standard;Human;Image;Image Analysis;image processing;improved;Individual;interest;Investigation;Knowledge;Link;Magnetic Resonance Imaging;Maintenance;Medical Imaging;Metadata;Methodology;Methods;Michigan;Modernization;Motor;multimodality;multisensory;National Institute of Neurological Disorders and Stroke;neuroimaging;Online Systems;Parkinson Disease;Patients;Phase;Positron-Emission Tomography;Process;programs;Protocols documentation;Recommendation;relational database;repository;Research;research and development;Research Personnel;Research Project Grants;Resources;Rest;Sampling;Scanning;Site;Standardization;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Students;success;System;Techniques;Thick;Time;Training;Translating;Universities;Visit;Visualization;Vocabulary;web site;white matter;Work

PROJECT_TITLE: Core D:  Biostatistics and Data Management Core


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PROJECT_TERMS: acetylcholine transporter;Anterior;Attention;Auditory;Binding;Brain;Brain region;catalyst;caudate nucleus;cholinergic;Clinical;Cognitive;cohort;Corpus striatum structure;Data;density;Development;Diffuse;disability;Disease Progression;entorhinal cortex;equilibration disorder;Equilibrium;Etiology;Evolution;Exhibits;Failure;falls;follow up assessment;follow-up;Freezing;Functional disorder;Funding;Gait;Gait abnormality;Geniculate body structure;Goals;Grant;Impairment;in vivo;Incidence;information processing;insight;Insula of Reil;Interneurons;Intervention Studies;Lateral Geniculate Body;Ligands;Link;Medial;Modeling;Motor;multisensory;National Institute of Neurological Disorders and Stroke;nerve supply;neural circuit;novel;novel therapeutic intervention;Parkinson Disease;Participant;Patients;Persons;Phenotype;Positron-Emission Tomography;posture instability;pre-clinical;Prefrontal Cortex;Prospective, cohort study;Recommendation;recruit;Refractory;Reporting;Research;Research Project Grants;Risk;Role;Sampling;Signal Transduction;Site;Structure;System;Testing;Thalamic structure;vestibular system;Visual;Visuospatial;way finding;Work

PROJECT_TITLE: Project I:  Evolution of cholinergic deficits within multisensory, cognitive, and motor integration brain regions and development of PIGD features in PwP


NIH_SPENDING_CATS: Aging;Brain Disorders;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

PI_NAMEs: BERRIDGE, KENT C. (contact)

PROJECT_TERMS: 5-HT6 receptor;acetylcholine receptor agonist;Address;Admission activity;Animal Model;antagonist;Attention;Attenuated;attenuation;basal forebrain;basal forebrain cholinergic neurons;Basic Science;Behavioral;Behavioral Paradigm;Biosensor;cholinergic;Clinical;Code;Combined Modality Therapy;Complement;Complex;Corpus striatum structure;Coupling;Cues;Data;Deafferentation procedure;Denervation;designer receptors exclusively activated by designer drugs;Detection;Disease Resistance;Dopamine;dopamine replacement therapy;effective therapy;Elements;Environment;equilibration disorder;Equilibrium;Excision;Exhibits;experience;experimental study;Fall prevention;falls;Freezing;Frequencies;Functional disorder;Funding;Gait;Gait abnormality;Gait speed;Generations;genetic approach;glutamatergic signaling;Glutamates;Hospitalization;Human;Immobilization;Impairment;in vivo;inhibitor;insight;Interneurons;Intervention;kinematics;Levodopa;Limb structure;Link;Maps;Measures;Mediating;Michigan;Modeling;Motor;motor control;Movement;National Institute of Neurological Disorders and Stroke;neural circuit;neuronal circuitry;Neurons;neurotransmission;Nicotinic Receptors;Nodal;novel;Nursing Homes;optogenetics;Oxidases;Parkinson Disease;Pathway interactions;Patients;Performance;Persons;pharmacologic;Phase;Positron-Emission Tomography;Pre-Clinical Model;Rattus;Recommendation;Reporting;Research;research and development;Research Project Grants;Resistance;Resources;Risk Factors;Rodent Model;Role;Signal Transduction;Symptoms;Synapses;synergism;System;Taxes;Testing;therapeutic development;therapy development;translational model;translational study;treadmill;Virus;Work

PROJECT_TITLE: Project II: Circuit Mechanisms of Attentional-Motor Interface Dysfunction in PD Falls


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: LAS CRUCES

ORG_DEPT: BIOLOGY

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE The collaboration between New Mexico State University (NMSU) and Fred Hutchinson Cancer Center (Fred Hutch) with its 20-year history of innovative and impactful partnership seeks to further support cancer research at NMSU, increase participation in health disparities research at Fred Hutch, and recruit, train and support underrepresented students and Early Stage Investigators in cancer research careers. The Partnership seeks to deliver outreach and education on cancer to underserved populations in the US southwest and Pacific northwest.

PI_NAMEs: SIMON, JULIAN ;UNGUEZ, GRACIELA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;anti-cancer research;Basic Science;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;career;Clinical;Collaborations;college;Communities;community collaboration;community engaged research;community engagement;community organizations;Comprehensive Cancer Center;Dedications;design;Education;Education and Outreach;education research;Environment;Equity;equity, diversity, and inclusion;Evaluation;Exclusion;experience;Faculty;Funding;Future;Goals;Graduate Degree;Health;Health Disparities Research;health disparity;health disparity populations;Health education;Health equity research;Health Sciences;improved;Individual;innovation;Institution;Internships;Joints;Knowledge;Laboratories;Malignant Neoplasms;meetings;member;Mentors;Mission;New Mexico;outreach;outreach program;Pacific Northwest;Participant;population health;Population Sciences;Process;programs;Public Health;Publications;Recording of previous events;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Scientist;Southwestern United States;Students;success;Time;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student;Voice;Washington;Work

PROJECT_TITLE: 1/2 Partnership for the Advancement of Cancer Research: NMSU & Fred Hutch


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: UNGUEZ, GRACIELA ALEXANDRA (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Budgets;Cancer Center;cancer health disparity;Cancer Research Project;Clinical;Communication;Communities;community collaboration;community organizations;community partners;COVID-19 pandemic;Development;Education and Outreach;education research;Effectiveness;Electronic Mail;Ensure;Environment;Evaluation Research;Exclusion;experience;Feedback;Fostering;Future;global health;Goals;health equity;Health Sciences;improved;Individual;Infrastructure;innovation;insight;Institution;interest;Leadership;learning community;Link;Lived experience;Location;Logistics;Malignant Neoplasms;meetings;member;Methods;Mission;National Cancer Institute;New Mexico;outreach;outreach program;pandemic disease;Participant;Persons;population health;Process;Productivity;Program Efficiency;programs;Recording of previous events;Reduce health disparities;Research;research faculty;Research Project Grants;Resource Allocation;Resources;Scientist;Source;Structure;Students;Study Section;System;Technology;Telephone;Time;undergraduate student;Underrepresented Populations;Universities;Videoconferencing;Washington;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine

PROJECT_TERMS: Acceleration;acetylcholine transporter;Anterior;Attention;basal forebrain;Biological;Biological Markers;Biology;biomarker development;biomarker identification;Brain;cholinergic;Clinical;clinical care;Clinical Research;Clinical stratification;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cohort;Collaborations;Complex;Denervation;Development;Diffuse;Disease;disease heterogeneity;disease phenotype;disorder subtype;dopamine replacement therapy;Evaluation;Fogs;Freezing;Functional disorder;Gait;Gait abnormality;Image;Impaired cognition;Impairment;improved;Incidence;Intervention;Knowledge;Ligands;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant - descriptor;Measures;Motor;motor disorder;National Institute of Neurological Disorders and Stroke;Natural History;Neurotransmitters;Parkinson Disease;personalized medicine;Phenotype;Positron-Emission Tomography;Prognosis;prospective;Recommendation;Refractory;Reporting;Research;Resources;Subgroup;synucleinopathy;System;targeted treatment;Testing;therapy development;Universities;Validation

PROJECT_TITLE: Project III: Cingulo-Opercular Task Control Network Cholinergic Dysfunction in PD


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Nanotechnology;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE We propose to translate a novel liquid biopsy platform for early cancer detection. Specifically, we will apply a forward-thinking nano-plasmonic platform for comprehensive, high-throughput molecular analyses of extracellular vesicles (EVs). We will rigorously address EVs' clinical utility to detect high- grade serous ovarian cancer in high-risk patient cohorts.

PI_NAMEs: CASTRO, CESAR M;LEE, HAKHO  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Acceleration;Address;Adoption;advanced disease;Ascites;assay development;Automation;Benign;biobank;Biological Assay;Biological Markers;biomarker panel;Blood;Blood specimen;Blood Tests;CA-125 Antigen;cancer biomarkers;cancer care;cancer diagnosis;cancer imaging;Cancer Model;Cancer Patient;cancer subtypes;Cells;Chromatography;circulating biomarkers;Circulation;Clinical;Clinical Research;clinical translation;cohort;comparative;Complement;design;Diagnostic;diagnostic value;Diameter;Disease;early detection biomarkers;Early Diagnosis;Epithelial ovarian cancer;Excision;exosome;extracellular vesicles;General Hospitals;Genetic Risk;Germ-Line Mutation;Goals;Gynecologic;high risk;high risk population;Hospitals;Image;Industry;insight;instrument;Intervention;Lesion;liquid biopsy;Liquid substance;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Massachusetts;Messenger RNA;Methods;minimal risk;minimally invasive;Molecular;Molecular Analysis;molecular dynamics;Monitor;multidisciplinary;Mus;nanoplasmonic;Nanotechnology;novel;Nucleic Acids;Operative Surgical Procedures;Organoids;Ovarian;Pathogenesis;Pathology;patient derived xenograft model;Patients;Performance;Perinatal;peripheral blood;Plasma;prophylactic;prospective;protein biomarkers;protein profiling;Proteins;Quality Control;Research;Resources;Sampling;screening;Screening for cancer;Screening for Ovarian Cancer;Serous;Site;Standardization;Statistical Data Interpretation;success;System;Systems Biology;Technology;Testing;Thinking;Time;tool;Translating;Tumor Burden;tumor progression;tumorigenesis;United States;Update;Validation;Woman

PROJECT_TITLE: Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic Array


PI_NAMEs: SHUSTER, MICHELE IRENE (contact)

PROJECT_TERMS: Academic support;Address;Advanced Malignant Neoplasm;Affect;Agreement;anti-cancer research;Area;Cancer Biology;Cancer Center;cancer health disparity;career;career development;Cessation of life;cohort;Collaborations;Communication;Communities;Conflict (Psychology);conflict resolution;Consultations;COVID-19 pandemic;Development;Education;Educational process of instructing;Educational workshop;Environment;Evaluation;Event;Exclusion;expectation;experience;Face;Faculty;faculty mentor;faculty support;flexibility;Fostering;Foundations;Grant;Growth;Heart;higher education;improved;Individual;Institution;Knowledge;Longevity;Malignant Neoplasms;Manuscripts;meetings;member;Mentors;Modeling;Monitor;New Mexico;outreach;pandemic disease;pandemic stressor;Participant;peer;Preparation;Process;Production;Research;Research Personnel;Resource Sharing;Resources;satisfaction;Scientist;Services;skills;Societies;student mentoring;Students;success;System;Teacher Professional Development;Time;Training;Travel;undergraduate student;Universities;Vocational Guidance;Work;Writing

PROJECT_TITLE: Core 1: Resource for AcademIc SuccEss (RAISE)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: AHMED, OMAR JAMIL (contact)

PROJECT_TERMS: Acetylcholine;Anterior;Attention;basal forebrain;Behavior;Bilateral;blood oxygenation level dependent response;Brain region;catalyst;cell cortex;cell type;Cells;cholinergic;Cholinergic Agonists;Cholinergic Receptors;cholinergic synapse;cingulate cortex;Code;Cognitive;cohort;Communication;Cues;Data;Disorientation;dopamine replacement therapy;Emotional;fall risk;Functional disorder;Future;Gait abnormality;Genetic;Head;Hemorrhage;Hippocampus;Impairment;in vivo;Individual;inhaled nitric oxide;Intervention;Lead;Lesion;Link;Maps;Modeling;Motor;motor control;Motor Cortex;Movement;Muscarinic Acetylcholine Receptor;Muscarinics;neural;Neurons;neuroregulation;optogenetics;Output;Parkinson Disease;Patients;Pattern;Persons;pharmacologic;Phase;Play;Positioning Attribute;Refractory;Research Project Grants;response;Role;Shelter facility;Signal Transduction;Space Perception;Speed;Stroke;Structure;superior colliculus Corpora quadrigemina;Synapses;System;Testing;Thalamic structure;Translating;transmission process;vestibular system;Visual Cortex;way finding;Work

PROJECT_TITLE: Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration Dysfunction


PI_NAMEs: JEON, SOYOUNG  (contact)

PROJECT_TERMS: Acute;Address;Advanced Malignant Neoplasm;anti-cancer research;Aspartate;Automobile Driving;Bioinformatics;Biological;Biometry;cancer cell;Cancer Model;Cancer Patient;cancer type;career;career development;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;Characteristics;Chronic;Citric Acid Cycle;Collaborations;community engagement;Community Health;Complex;Data;Data Analyses;Data Set;Defect;Dependence;design;education research;Educational Status;Educational workshop;Electron Transport;Environment;Enzymes;Epigenetic Process;epigenomics;Ethnic Origin;experience;Face;Fostering;Gene Expression Process;Genetic Transcription;Genotype;Health;health disparity;Human;Hypoxia;Impairment;improved;improved outcome;inhibitor;Institution;Interdisciplinary Study;Intervention;Intrinsic factor;Joints;Knowledge;loss of function mutation;Machine Learning;machine learning model;Malignant Neoplasms;Measurement;meetings;member;Mentors;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Metadata;Mitochondria;Modeling;multidisciplinary;mutant;Mutation;next generation;novel;novel therapeutic intervention;Nutrient;Oncogenic;Outcome;outreach;Oxygen;Pathway Analysis;Patients;Pilot Projects;pressure;prevent;Process;Proliferating;protein expression;Proteins;Proteomics;proteostasis;Race;Reactive Oxygen Species;Reproducibility;Research;research data dissemination;Research Personnel;Research Support;Resources;response;restoration;Science;Scientist;Statistical Methods;statistics;student training;Students;success;Succinate Dehydrogenase;Succinate dehydrogenase (ubiquinone);Supporting Cell;System;targeted cancer therapy;Techniques;Time;Tissues;Training;transcriptomics;tumor;tumor metabolism;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Underrepresented Students;underserved community

PROJECT_TITLE: Project 2: Systemic Understanding of Cellular Mechanisms of Metabolic Adaptations in Cancer


ADMINISTERING_IC: DE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Prevention

ORG_CITY: STOCKTON

ORG_NAME: UNIVERSITY OF THE PACIFIC-STOCKTON

ORG_STATE: CA

PHR: Pacific-Stanford PRIMED Program –Project Narrative The Pacific-Stanford PRIMED Program will foster a culture where oral health clinicians and students view practice-based research as a routine component of their regular daily clinical practice, and train the next generation of clinical oral health researchers to effectively translate biomedical research findings into their clinical practice to ensure optimal oral health outcomes. The program will provide clinical research skills development for dental students and clinicians, through formal training as well as mentorship. The University of the Pacific and Stanford University have a longstanding history of collaboration and are ideal partners to engage research faculty, clinical faculty, students, and residents to conduct practice-based research in three areas: sleep medicine, oral cancer and developing the Pacific-Stanford biobank.

PI_NAMEs: LAM, DAVID K (contact);MOAZZEZ, REBECCA ;O'HARA, RUTH M;SUNWOO, JOHN B

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Affect;Annual Reports;Area;Attitude;biobank;Biomedical Research;career;Certification;Chalk;Clinic;Clinical;clinical care;clinical development;clinical practice;Clinical Research;Collaborations;Data;Data Collection;Dental;Dental Clinics;Dental Schools;Dental Students;disorder prevention;Education;education research;Ensure;Event;Faculty;Feeling;Fostering;Future;Goals;Health;health disparity;Hour;improved;inter-institutional;Knowledge;Life;malignant mouth neoplasm;Medicine;meetings;Mentors;Mentorship;Mouth Diseases;next generation;Nursing Faculty;Oral;Oral health;Outcome;Participant;Patient Care;Patients;peer coaching;Personal Satisfaction;Practice based research;programs;Publications;Recording of previous events;recruit;Reporting;Research;research faculty;Research Personnel;Research Support;Resources;Running;sample collection;Schedule;Scientist;Site;skill acquisition;Sleep;student mentoring;student participation;Students;Surveys;Teacher Professional Development;timeline;Training;Translating;Universities;web site;Work

PROJECT_TITLE: Pacific-Stanford PRIMED Program: Training the next generation of clinical oral health researchers


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOTHELL

ORG_NAME: PHARMAIN CORPORATION

ORG_STATE: WA

PHR: Narrative: The 5-year survival rate for children with metastatic osteosarcoma (OSA) is extremely low, hovering around 20%-30%, a rate that has not improved in over 30 years. Novel therapies are in critically needed, specifically molecules capable of inhibiting the process of OSA metastasis. This SBIR Phase 2 application will support IND enablement of an immunomodulating peptide with unique anti-tumor and anti-fibrotic properties that PharmaIN is developing for the treatment of osteosarcoma and other cancer types.

PI_NAMEs: ALFARO, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Accounting;Acute;Adjuvant Chemotherapy;Adolescent;analytical method;antifibrotic treatment;Biological Assay;bone;C-Type Natriuretic Peptide;Cancer Model;cancer type;Canis familiaris;chemotherapy;Chest;Child;Cisplatin;Clinical;Clinical Research;Clinical Trials;Cyclic GMP;Data;Data Set;Development;Diagnosis;Disease;Dose;Doxorubicin;Engineering;Excision;Feedback;Femur;Formulation;Freeze Drying;Freezing;Funding;Human;humerus;immunoregulation;improved;In Vitro;Lead;Life;limb bone;Liquid substance;Localized Disease;long bone;Lung;Malignant Neoplasms;manufacture;Measures;meetings;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;Methods;Methotrexate;Micrometastasis;Modeling;Neoadjuvant Therapy;Neoplasm Metastasis;Newly Diagnosed;novel therapeutics;Operative Surgical Procedures;Osteosarcoma;Patients;Pediatric Neoplasm;Peptides;Perioperative;Pharmaceutical Preparations;Phase;Population Control;Primary Lesion;Process;product development;Progressive Disease;Property;Rattus;Reporting;Sampling;Small Business Innovation Research Grant;Specific qualifier value;standard of care;success;Survival Rate;tibia;Time;tool;Translations;tumor;Work

PROJECT_TITLE: Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Natural Products;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GUZMAN, IVETTE  (contact)

PROJECT_TERMS: Adult;Advanced Malignant Neoplasm;anti-cancer research;Ascorbic Acid;Back;Behavioral Research;Biological Availability;Biological Markers;Blood;Cancer Center;cancer health disparity;cancer prevention;cancer recurrence;cancer risk;Cardiometabolic Disease;career;Carotenoids;Chlorophyll;Chronic Disease;Collaborations;Communities;Community Actions;community based research;community collaboration;comorbidity;Computer software;Consumption;cooking;County;Cross-Over Trials;design;Diet;dietary;Dietary Intervention;Dietary Practices;Digestion;Dryness;education research;Educational Curriculum;Educational Intervention;Effectiveness;effectiveness testing;Environment;Evaluation;evidence base;Exclusion;experience;faculty mentor;Folic Acid;Food;fruits and vegetables;Funding;Future;graduate student;Health;Health Sciences;Hispanic;human centered design;improved;In Vitro;Information Systems;Infrastructure;Intake;Intervention;Knowledge;Latinx;Lived experience;Low income;Malignant Neoplasms;Measurable;meetings;member;Mentors;meter;Methods;Mexican;Modeling;Modernization;New Mexico;nutrition;Outcome;Outcome Measure;outreach;Participant;Phytochemical;Phytonutrients;Pilot Projects;Plants;population health;portion control;Prevention education;Preventive;primary outcome;Process;Program Evaluation;programs;Public Health;Public Health Education;Randomized;Recipe;recruit;Research;Research Personnel;Resources;Risk;Scientist;secondary outcome;Self Efficacy;Services;Spanish/English;Spottings;Students;success;systems research;Testing;Time;Tocopherols;Training;Translating;trial design;Universities;Variant;Vitamin B Complex;vulnerable community;Vulnerable Populations;Waiting Lists

PROJECT_TITLE: Project 3: A Transdisciplinary Approach to Increasing Phytonutrients in New Mexican Diets: A Kitchen-to-Lab-to-Table Model


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The applicant group led by the Principal Investigator (PI) has conducted a series of Early Detection Research Network (EDRN) defined Phase 1-3 biomarker studies that have led to the identification and development of a panel of circulating proteins as well as autoantibodies directed against tumor proteins (including TP53 and novel citrullinated antigens) for detection of breast and ovarian cancers. The primary translational objective of this project is to advance candidate biomarkers for detection of breast and ovarian cancers via testing in pre- diagnostic plasmas from the Prostate Lung Colorectal and Ovarian (PLCO) cohort and to develop a multi-analyte blood-based biomarker panel based on protein and autoantibody biomarkers for risk assessment of breast and ovarian cancers. The resulting biomarker test would then be integrated with other risk models based on individual subject characteristics, such as the Gail Model for breast cancer, to deliver personalized cancer risk assessment and inform on a need for further pertinent tests that enable earlier diagnosis.

PI_NAMEs: FAHRMANN, JOHANNES F (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Algorithms;Antigens;Autoantibodies;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Blood Tests;blood-based biomarker;Breast Cancer Detection;Breast Cancer Prevention;Breast Cancer Risk Assessment Tool;cancer risk;candidate marker;Characteristics;Clinical;cohort;Colorectal;Data;Development;Diagnosis;Diagnostic;Disease;Early Detection Research Network;Early Diagnosis;Exhibits;Female;follow-up;Immunoassay;improved;Individual;long short term memory;Lung;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Modeling;multidisciplinary;novel;Ovarian;Participant;Patients;Pattern;Performance;personalized biomarkers;Phase;Plasma;pre-clinical;Predictive Value;Principal Investigator;Probability;Prostate;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Proteins;Random Allocation;recurrent neural network;Resources;Risk;Risk Assessment;risk prediction;risk prediction model;Sampling;screening;screening program;Series;Specificity;Specimen;Standardization;success;Technology;Testing;Time;tool;TP53 gene;tumor;Tumor Antigens;Validation;validation studies

PROJECT_TITLE: Blood-Based Biomarkers for Personalized Risk Assessment of Breast and Ovarian Cancer


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE  Alzheimer’s disease (AD) is the leading cause of dementia worldwide in older individuals, while HIV associated neurocognitive disorder (HAND) is prevalent in 20-50% of people with HIV, who live longer due to successful antiviral therapy, being the leading cause of dementia in younger individuals. The crosstalk between the signaling pathways of AD and HAND warrant studies to better understand the neuropathologic mechanisms and identify novel candidates for therapies. Studying the altered interferon type 1 immune response in monocytes will yield novel information on how interactions between immunologic signaling and the CNS contribute to cognitive impairment.

PI_NAMEs: CANTRES-ROSARIO, YISEL M. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Abeta clearance;Academia;Affect;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease patient;Amyloid beta-42;Amyloid beta-Protein;Anti-Inflammatory Agents;Anti-viral Therapy;antiretroviral therapy;Basic Science;Biology;Blood;Blood - brain barrier anatomy;Brain;brain tissue;candidate identification;CD14 gene;Cells;Cellular biology;Central Nervous System;Cerebrospinal Fluid;Characteristics;Clinical;Coculture Techniques;Cognition;Cognitive;cognitive function;Collecting Cell;CRISPR/Cas technology;cytokine;Data;Dementia;Development;effective therapy;Ensure;Etiology;Exhibits;Exposure to;FCGR3B gene;Gene Expression;genetic variant;Goals;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-associated neurocognitive disorder;Homeostasis;Human;Immune;Immune response;Immune signaling;Immune System Diseases;Immunity;Immunology;Impaired cognition;Impairment;In Vitro;Individual;induced pluripotent stem cell;Infection;Infiltration;Inflammation;Inflammatory;Insulin;Insulin Receptor;insulin receptor substrate 1 protein;Insulin Resistance;insulin signaling;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;knock-down;Knowledge;Macrophage;Measures;Mediating;Mentors;Metabolic;Metabolism;Methodology;Modeling;monocyte;multidisciplinary;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;Neuronal Dysfunction;Neurons;Neuropathogenesis;neuropathology;neuroprotection;Neuropsychology;novel;Older Population;Organoids;Pathogenesis;Pathway interactions;Patients;Performance;Peripheral;Peripheral Blood Mononuclear Cell;Peripheral Nervous System;Persons;Phagocytes;Phagocytosis;Phase;Phenotype;Phosphorylation;Plasma;Population;postsynaptic;presynaptic;Prevalence;Process;Production;protein expression;Reactive Oxygen Species;receptor expression;Receptor Signaling;recruit;Regulation;Research Personnel;Research Training;response;restoration;Role;Senile Plaques;Signal Pathway;Signal Transduction;skills;Surface;Technical Expertise;Techniques;Testing;three dimensional cell culture;Tissue Donors;Tissues;tool;Training;Translational Research;type I interferon receptor;Viral;Virus Replication;Vocational Guidance

PROJECT_TITLE: nbInnate Immunity Responses In Monocytes: Contribution To Neurodegeneration


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: STIMATZE, TAMARA  (contact)

PROJECT_TERMS: Abstinence;Accounting;Address;Adult;Advanced Malignant Neoplasm;anti-cancer research;arm;Biochemical;Cancer Research Project;career development;Cessation of life;Cigarette;Communities;community advisory board;community engaged approach;community organizations;comparison group;Counseling;culturally appropriate intervention;Data;design;Development;diaries;digital;digital intervention;Disparity;Disparity population;education research;effectiveness testing;efficacy outcomes;Electronic Nicotine Delivery Systems;empowerment;Environment;Equity;Ethnic Origin;Evaluation;experience;Feedback;flexibility;follow-up;Future;Gender Identity;gender minority community;gender minority group;Health;High Prevalence;individualized medicine;innovation;Intervention;Interview;Language;Latinx;Lead;Lived experience;Malignant Neoplasms;Media Intervention;member;Methods;mhealth interventions;Modification;mortality;National Cancer Institute;New Mexico;Nicotine;nicotine user;novel;novel strategies;outreach;Pharmacotherapy;Pilot Projects;pilot trial;Population;Prevalence;Preventable cancer cause;primary outcome;Process;programs;psychologic;queer;Randomized, Controlled Trials;Readiness;recruit;Reduce health disparities;Research;Research Personnel;Research Training;Resources;Risk;satisfaction;Science;secondary outcome;Sex Orientation;Sexual and Gender Minorities;sexual minority group;Smoke;Smoker;smoking cessation;smoking prevalence;Smoking treatment;social media;Spanish;Structure;Students;success;Testing;theories;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco user;Training;treatment effect;treatment group;Treatment outcome;treatment research;trend;United States National Institutes of Health;user centered design;Work;young adult

PROJECT_TITLE: Project 4: Culturally-Tailored, Avatar-Led mHealth Intervention to Aid Smoking Cessation Among Sexual and Gender Minority Young Adults in New Mexico


ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative We will determine 1) how tumors and the tumor microenvironment accumulate fatty acids and use them to induce lipid peroxidation in tumor-infiltrating CD8+ TTE or TEM cells; 2) how lipid peroxidation induces CD8+ TTE or TEM cell ferroptosis and dysfunction in tumor beds, and 3) explore new methods to counteract fatty acid effects and to restore T cell function in cancer patients. We hypothesize that inhibiting T cell ferroptosis will effectively enhance the therapeutic efficacy of immunotherapy in cancer patients. Completing this project will allow us and others to identify novel therapeutic targets and develop new methods to improve the efficacy of current cancer immunotherapies.

PI_NAMEs: YI, QING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Cell Transfers;Beds;Blood;Bone Marrow;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;CD36 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;Clinical;Coenzyme A;comparison control;cytokine;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Effector Cell;effector T cell;Enzymes;fatty acid oxidation;Fatty Acids;Functional disorder;Gene Expression;Genes;immune checkpoint blockade;Immunotherapy;Impairment;improved;In complete remission;Individual;individual patient;Infiltration;Interferon Type II;knock-down;lipid metabolism;Lipid Peroxidation;Malignant Neoplasms;Mediating;Melanoma;Melanoma patient;Memory;Metabolic;Methods;Modeling;Multiple Myeloma;Mus;new therapeutic target;novel;novel therapeutic intervention;oxidation;Oxidoreductase;Patients;Polyunsaturated Fatty Acids;Production;Prognosis;programs;Publications;Reporting;response;Role;single-cell RNA sequencing;success;T-Lymphocyte;terminally differentiated effector memory (TEM) T cells;Testing;TNF gene;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Burden;tumor microenvironment;uptake

PROJECT_TITLE: Role of lipid metabolism in CD8+ T cell ferroptosis


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE  The Colorado Learning Disabilities Research Center (CLDRC) is a long-standing interdisciplinary, multisite research program that investigates the genetic and environmental etiologies, neurobiology, neuropsychology, classification, and outcomes of specific learning disabilities (SLDs).

PI_NAMEs: WILLCUTT, ERIK G (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Anxiety;Attention deficit hyperactivity disorder;Basic Science;Behavioral;Benchmarking;career;career development;Child;Classification;Clinic;clinical training;Cognitive;Collaborations;Colorado;Communities;community engagement;Community Health Education;comorbidity;Development;Differential Diagnosis;Disability research;Disease;Distal;Ensure;Equity;Etiology;Family;Funding;Future;Genetic;Genomics;Goals;Health Services Accessibility;Individual;Infrastructure;innovation;Instruction;Intervention;Laboratories;Leadership;Learning Disabilities;Learning Disorders;Measures;member;Mentorship;Methods;Modeling;Neurobiology;neuroimaging;Neuropsychology;next generation;Outcome;Policies;polygenic risk score;Positioning Attribute;prevent;programs;Publications;Publishing;Reading;recruit;Research;Research Personnel;Resources;Risk Factors;risk sharing;Role;Sampling;Scientist;Site;Time;Training Programs;Translating;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Differential Diagnosis in Learning Disabilities


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Social Determinants of Health

PI_NAMEs: MAGOC, DEJAN  (contact)

PROJECT_TERMS: 11 year old;18 year old;Accelerometer;active lifestyle;Address;Adolescence;Adult;Advanced Malignant Neoplasm;after-school program;Age;American;anti-cancer research;Behavior;behavior change;Body mass index;Cancer Center;cancer risk;cancer type;career development;Cellular Phone;Child;Childhood;Chronic Disease;Clinical;Collaborations;Colorectal Cancer;community academic partnership;community engaged research;Computers;cost;County;design;Diabetes Mellitus;Diet Habits;Disease;Disparity;Education;education research;efficacy evaluation;Electronics;Environment;Epidemic;Evaluation;Facebook;Family;Family member;feasibility testing;fifth grade;Fostering;Fruit;fruits and vegetables;Funding;Goals;graduate student;Guidelines;Health;health disparity;health equity promotion;Health Food;Healthy Eating;healthy lifestyle;Heart Diseases;high body mass index;Hispanic;Hodgkin Disease;Home;Hour;Household;improved;innovation;Institution;Intake;Leisures;leukemia;Life;Life Style;Long-Term Effects;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Mentorship;mortality;New Mexico;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;oral communication;outreach;Overweight;Parents;Physical activity;physical inactivity;Pilot Projects;pilot test;Play;Preparation;Prevalence;Prevention program;Privatization;programs;Protocols documentation;Recommendation;Recreation;recruit;Reduce health disparities;Reporting;Research;Research Project Grants;Risk;school district;Schools;Science;Scientist;sedentary lifestyle;Site;skills;Sleep;social;Stroke;Students;Surveys;Teenagers;Television;Testing;Time;tv watching;undergraduate student;underserved community;Universities;Update;Video Games;Washington;Writing;Yakima Valley

PROJECT_TITLE: Pilot Project 1: H-PACE: Promoting Healthy Living Through Behavior Change


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: Achievement;Address;Age;Attention;Awareness;Behavior;Behavioral Sciences;Benchmarking;Budgets;career;Clinic;Clinical Sciences;Collaborations;Colorado;Communication;Communities;community engaged approach;Development;Differential Diagnosis;Ensure;Family;follow up assessment;Follow-Up Studies;Infrastructure;Institution;International;Learning;Learning Disabilities;Mathematics;Measures;Molecular Genetics;Monitor;neuroimaging;Neuropsychology;Neurosciences;operation;Paper;Participant;participant retention;Procedures;Progress Reports;Psychopathology;Publishing;Quantitative Genetics;Reading;recruit;Research;Research Personnel;Research Project Grants;research study;Risk;Sampling;Scholarship;Services;Site;Slide;Social Sciences;Specific qualifier value;success;System;Twin Multiple Birth;Twin Studies;Underrepresented Populations;Universities;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

PROJECT_TERMS: 3-Dimensional;Address;Area;Basic Science;career;career development;Child;child services;Clinic;Clinical;clinical training;Collaborations;Colorado;Communities;community center;Community Developments;community engaged research;community engagement;Crowns;Development;Development Plans;Differential Diagnosis;Disease;Economics;effectiveness evaluation;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Excision;Family;Grant;Health Services Accessibility;Individual;Information Dissemination;insight;Institution;interest;Intervention;Knowledge;Lead;Learning Disabilities;low socioeconomic status;member;Mentorship;Methods;Monitor;Neuropsychology;outreach;Policies;prevent;Procedures;Publications;Research Personnel;research study;Resources;Scholars Program;Scholarship;Scientist;service learning;Services;skill acquisition;Slide;Structure;Technology;Training;Training Support;Translations;Universities;webinar;Writing;Youth

PROJECT_TITLE: Engagement Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: BOREN, RACHEL  (contact)

PROJECT_TERMS: Accountability;Address;Advanced Malignant Neoplasm;Advisory Committees;American;anti-cancer research;Assessment tool;Cancer Center;cancer health disparity;Cancer health equity;career;Collaborations;Communication;Communities;community academic partnership;Community Actions;community engagement;Consensus;Consultations;Data;Data Analyses;data collection methodology;Decision Making;Education;Effectiveness;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Evaluation Methodology;Evaluation Research;evidence base;Faculty;Faculty Recruitment;Familiarity;Funding;Goals;Grant;health equity;Impact evaluation;implementation evaluation;improved;Individual;innovation;Institution;instrument;Interview;Lead;Logic;Malignant Neoplasms;Measures;meetings;member;Modeling;New Mexico;Outcome;Outcome Assessment;Outcome Measure;outreach;Pacific Northwest;Participant;Policies;Process;Productivity;Program Evaluation;programs;Publications;Questionnaires;Recommendation;Regional Cancer;Reporting;Request for Applications;Research;Research Project Grants;Science;Scientist;Southwestern United States;Students;Study Section;success;Suggestion;Surveys;synergism;Techniques;Training;translational health science;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Planning & Evaluation Core


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: analytical method;Anxiety;Attention deficit hyperactivity disorder;career;Clinic;Communities;Complex;complex data;Data;Data Analyses;Data Analytics;Data Collection;Data Files;data management;data repository;Data Set;data sharing;database of Genotypes and Phenotypes;Databases;Development;Differential Diagnosis;Documentation;Education;Equation;Etiology;experience;Faculty;flexibility;follow up assessment;Funding;genome wide association study;Genomics;Individual;Information Dissemination;Infrastructure;innovation;Intervention;Investments;Learning Disabilities;Libraries;Literature;Location;longitudinal dataset;longitudinal design;Measurement;Measures;member;Meta-Analysis;Methods;Modeling;Molecular Genetics;National Institute of Child Health and Human Development;neuroimaging;Neuropsychology;online repository;Participant;Policies;Procedures;Protocols documentation;Psychopathology;public database;Qualifying;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Sampling;Science;Scientist;secondary analysis;Siblings;Statistical Data Interpretation;Statistical Methods;Structure;Text;Twin Multiple Birth;Twin Studies;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Data Core


ORG_CITY: Cambridge

ORG_NAME: VINCERE BIOSCIENCES, INC.

PHR: NARRATIVE Parkinson’s Disease is an age-associated neurodegenerative disorder affecting nearly 1 million Americans, and present treatments provide only symptomatic benefit, with disease progression resulting in diminished efficacy and often intolerable motor complications. Mitochondrial dysfunction is tightly involved in the loss of dopaminergic neurons central to the disease, raising the possibility clearance of damaged mitochondria via increased mitophagy may hold disease modifying benefit. We developed potent and selective USP30 inhibitors that promote mitophagy in cells, which we now propose to evaluate in vivo for their potential as first-in-class therapeutics to stop or slow progression of Parkinson’s Disease.

PI_NAMEs: BEHROUZ, BAHAREH  (contact);HENDERSON, MICHAEL

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acute;Address;Affect;age related neurodegeneration;age-related disease;alpha synuclein;American;Animal Model;Animals;antimycin;Automobile Driving;Autopsy;Back;Binding Proteins;Biochemical;Biological Assay;Biological Sciences;Biology;Biotechnology;Brain;Cell Count;Cell Line;cell type;Cells;Central Nervous System Diseases;Clinic;Clinical;clinical development;Clinical Trials;Complex;Corpus striatum structure;cytotoxicity;Data;Deubiquitinating Enzyme;Development;Disease;Disease Pathway;Disease Progression;Dopamine;dopaminergic neuron;Dose;Drosophila genus;drug discovery;Drug Kinetics;Elements;Experimental Designs;experimental study;FBXO7 gene;Female;Future;Genetic;Genetic Models;Homeostasis;Human;Human Genetics;Idiopathic Parkinson Disease;In Vitro;in vitro activity;in vivo;in vivo evaluation;inhibitor;Investigational Drugs;Investments;Kinetics;knock-down;Knowledge;Lead;lead candidate;Letters;Licensing;Light;Link;LRRK2 gene;male;Manuscripts;Measures;Mediating;Methods;Microsomes;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Motor;mouse model;multidisciplinary;Mus;Mutation;nanomolar;Nerve Degeneration;Neuronal Differentiation;Neurons;neuroprotection;neurotransmission;novel;Oligomycins;Other Genetics;overexpression;Paper;Paraquat;Parkin;Parkinson Disease;pars compacta;Pathogenesis;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Penetration;Permeability;Persons;Pharmaceutical Chemistry;Pharmacodynamics;Pharmacology;PINK1 gene;Plasma;Plasma Proteins;Positioning Attribute;pre-formed fibril;Property;Rattus;Regimen;Risk Factors;Rodent;Series;Sex Differences;small molecule;small molecule inhibitor;Solubility;sporadic Parkinson's Disease;Study models;Substantia nigra structure;success;Testing;Therapeutic;Tissues;Toxic effect;Toxin;ubiquitin isopeptidase

PROJECT_TITLE: In vivo Evaluation of USP30 Inhibitors in Models Relevant to Parkinson's Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine;Rehabilitation;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The patient perspective is essential for managing unilateral vocal fold paralysis, which affects 16 million persons in the US who have significant difficulty communicating, eating, and breathing. Patients with acute paralysis have profound mental and physical health effects that limit everyday activities and demonstrate variable responses to treatment due to unique patient characteristics and baseline disability. We therefore address the need to individualize how we assess treatment effectiveness using patient-reported outcome measures (PROM) at the point of care by using an innovative statistical machine-learning approach that accounts for the value the individual patient puts on outcomes related to voice, psychosocial, and swallowing.

PI_NAMEs: FRANCIS, DAVID O. (contact);ZHAO, JIWEI

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acute;Address;Adult;Affect;Aftercare;Aspiration Pneumonia;Biometry;Breathing;Characteristics;Climacteric;Clinic;Clinical;clinical decision-making;Clinical Trials;clinically relevant;Communication difficulty;Communication impairment;Decision Making;Deglutition;design;disability;Disability Evaluation;Distress;Eating;Effectiveness;Employment;Etiology;expectation;experience;forging;Functional disorder;Functional impairment;Goals;Health;Health Services Research;Healthcare;Heterogeneity;Impairment;improved;individual patient;Injections;Injury;innovation;Intervention;machine learning method;Measures;Mental Health;Methods;novel;observational cohort study;Occupational;Outcome;Outcome Measure;Paralysed;Patient Care;Patient Outcomes Assessments;patient population;Patient Preferences;patient response;Patients;personalized approach;Persons;physical conditioning;point of care;Provider;psychosocial;Quality of Care;Quality of life;Recurrent Laryngeal Nerve;Reporting;Research;Risk;Severities;Site;sociodemographics;Speech Therapy;standard of care;Standardization;statistical and machine learning;Subgroup;supervised learning;Surveys;Symptoms;teacher;Testing;theories;Thyroidectomy;tool;treatment effect;Treatment Effectiveness;treatment response;Universities;Use Effectiveness;vocal cord;Voice;voice therapy;Wisconsin;Work

PROJECT_TITLE: CoPE II: Individualizing patient-reported outcomes in patient care for vocal fold paralysis in the clinic and in research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCOTT, MARY ALICE (contact)

PROJECT_TERMS: Academic support;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Area;Biological Sciences;Biomedical Research;Cancer Biology;cancer health disparity;Cancer health equity;Career Mobility;Collaborations;Communication;Communities;Creativeness;design;Development;Discipline;Education;education research;Educational Activities;Effectiveness;Environment;equity, diversity, and inclusion;Ethnic Population;Evaluation;Exclusion;experience;Feedback;formative assessment;Funding;Future;Goals;graduate student;Grant;Health;Health Disparities Research;health disparity;health equity;improved;Individual;innovation;Institution;interest;Internships;Joints;Knowledge;learning community;Malignant Neoplasms;Measures;meetings;member;Motivation;Names;next generation;Participant;population health;Positioning Attribute;Process;Program Evaluation;programs;Public Health;public health research;Public Health Schools;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;role model;Science;Scientist;skills;social group;Students;success;synergism;tool;Training;Training and Education;Training Programs;undergraduate student;underserved community;Universities;Washington;Work

PROJECT_TITLE: Research Education About Cancer and Health (REACH) Core


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric

PROJECT_TERMS: Academic achievement;Age;Anxiety;Attention;Attention deficit hyperactivity disorder;Child;Childhood;Clinic;Cognitive;cognitive ability;Cognitive deficits;cognitive task;Collaborations;Communities;community collaboration;comorbidity;Complement;Development;Diagnosis;Differential Diagnosis;Dimensions;Disease;emerging adult;Enrollment;Equation;Etiology;examination questions;executive function;follow up assessment;follow-up;Follow-Up Studies;Functional impairment;Funding;Individual;Laboratories;Learning Difficulty;Learning Disabilities;Learning Disorders;Life;lower income families;Mathematics;Measures;member;Mental disorders;Methods;Minority;Modeling;Motor;Names;Neuropsychology;Nursery Schools;Onset of illness;Outcome;Parents;Participant;phonology;processing speed;Production;Psychopathology;Reading;reading comprehension;reading difficulties;Research Personnel;Sampling;secondary analysis;Short-Term Memory;Specificity;Speed;spelling;Structure;Subgroup;sustained attention;Symptoms;Testing;Time;Twin Multiple Birth;Twin Studies;vigilance;Work;Writing

PROJECT_TITLE: Understanding comorbidity between specific learning disabilities and developmental psychopathology


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Alcohol addiction is a chronic brain condition that severely damages the lives of affected patients and their families, exerting a tremendous burden on society at large with currently available treatments not showing efficacy in most patients. An emerging research field for treatment of alcohol addiction is the interface of metabolic and epigenetic regulation in brain function; in this proposal, we seek to clarify whether alcohol consumption engages a novel epigenetic-metabolic pathway, via acetate signaling from liver alcohol breakdown directly to neuronal gene regulation. This work will help to discover new targets for novel treatment strategies and therapeutic interventions for alcohol use disorders.

PI_NAMEs: MEWS, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acetaldehyde;Acetates;Acetyl Coenzyme A;Acetylation;addiction;Adult;Affect;Alcohol consumption;Alcohol dehydrogenase;Alcohol dependence;alcohol effect;alcohol response;alcohol use disorder;alcoholism therapy;Alcohols;Animal Model;Animals;Award;Behavior;Behavioral;behavioral response;Binding;binge drinking;Biological Assay;Brain;Brain Diseases;career;Chromatin;Chronic;clinically relevant;comparison control;Complement;Consummatory Behavior;Consumption;cost;Coupled;Darkness;Data;defined contribution;Deposition;Development;Disease;drinking;drinking behavior;Drug Addiction;Enzymes;Epigenetic Process;epigenetic regulation;epigenomics;Ethanol Metabolism;Etiology;extracellular;Family;fomepizole;Future;Gene Expression;Gene Expression Regulation;gene function;Generations;Genes;genetic manipulation;Genetic Transcription;genome-wide;Goals;Grant;Hepatic;Hippocampus;Histone Acetylation;Histones;human model;in vivo;Induced Neurons;information processing;inhibitor;Injections;innovation;Intoxication;Investigation;knock-down;learned behavior;Learning;Link;Liver;Lysine;Mediating;Memory;memory process;Mentors;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Nature;neural;Neurobiology;Neurons;neurotransmission;new therapeutic target;novel;Nuclear;overexpression;Pathologic;Pathway interactions;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Process;programs;Proteins;Public Health;recruit;Research;reward circuitry;Rodent;Role;Scientist;Signal Transduction;social;Societies;Stimulus;Technical Expertise;Testing;Therapeutic Intervention;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;treatment strategy;United States National Institutes of Health;Viral;Viral Vector;Work

PROJECT_TITLE: Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Kidney Disease;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and exhibits multiple nearly universal metabolic alterations compared to adjacent healthy tissue. The proposed research herein builds on prior studies involving the gluconeogenic enzyme Fructose-1,6- bisphosphate 1 (FBP1), urea cycle enzymes, and lipid accumulation as defining hallmarks of this disease. Characterization of consistent and dramatic metabolic changes, and their downstream outputs, has revealed novel strategies for ccRCC treatment that can be extended to other cancers with similar metabolic features, such as hepatocellular carcinoma and soft tissue sarcoma.

PI_NAMEs: SIMON, M. CELESTE (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Angiogenesis Inhibitors;Antineoplastic Agents;ARG2 gene;argininosuccinate lyase;argininosuccinate synthase;Biochemical Pathway;cancer subtypes;Cells;Cholesterol Esters;cholesterol transporters;Clear cell renal cell carcinoma;Complex;Copy Number Polymorphism;Data;Diagnosis;Disease;Disseminated Malignant Neoplasm;Drops;Enzymes;Excision;Exhibits;Fibroblasts;Fructose;Future;Heterogeneity;High Density Lipoprotein Cholesterol;Human;Immune;immune checkpoint blockade;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;innovation;KRAS2 gene;Lipids;Malignant Neoplasms;men;Metabolic;Metabolic Pathway;metabolomics;Modeling;Molecular;mouse model;Mutation;Neighborhoods;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Organelles;Organoids;Output;patient derived xenograft model;Patients;Pharmaceutical Preparations;PIK3CG gene;Primary carcinoma of the liver cells;PTEN gene;Receptor Protein-Tyrosine Kinases;Relapse;Renal Carcinoma;Renal Cell Carcinoma;Research;senolytics;Soft tissue sarcoma;targeted treatment;Therapeutic;Tissues;TP53 gene;transcriptomics;Triglycerides;tumor;tumor metabolism;Tyrosine Kinase Inhibitor;United States;urea cycle;Vascular Endothelial Growth Factors;Woman;Work

PROJECT_TITLE: Metabolic Influences on Complex Tumor Neighborhoods


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Active Learning;Address;Advanced Malignant Neoplasm;Affect;American Indians;anti-cancer research;Behavior;Cancer Control;cancer education;Cancer Etiology;cancer prevention;colorectal cancer screening;Communities;community academic partnership;Community Actions;community based participatory research;community collaboration;community engaged research;community engagement;Community of Practice;community organizations;community partners;community partnership;community-centered;Country;COVID-19;COVID-19 outbreak;COVID-19 pandemic;Decision Making;Detection;Development;diversity and inclusion;E-learning;Education;Educational workshop;Elements;Ensure;Environment;Equity;Evaluation;evidence base;Evidence based program;experience;Faculty;Fostering;Funding;Geographic Locations;health equity;Health Insurance;Healthy Eating;healthy lifestyle;high school;Hispanic;improved;Individual;Inequity;Infrastructure;Intervention;Knowledge;Latinx;Learning;lens;low health literacy;Low income;Malignant Neoplasms;marginalized community;Measures;Medically Underserved Area;member;Mexico;Navajo;New Mexico;Outcome;outreach;Outreach Research;Persons;Pilot Projects;Policy Making;Population;Poverty;Prevention;Prevention education;Process;Research;Research Activity;research in practice;Research Methodology;Research Project Grants;Research Training;rural underserved;Science;screening program;Series;Services;social;social media;Spanish/English;Students;Training;Training and Education;Trust;Underserved Population;Vaccination;Voice;Washington;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Pediatric cancer, the number one cause of disease-related death in school age children, is still largely treated with old approaches such as cytotoxic chemotherapy, radiation, and surgery. These childhood malignancies typically express cancer-promoting proteins that make for challenging drug targets and generally have been less responsive to immunotherapy approaches that have revolutionized the care of subsets of adults with cancer. We will apply innovative, transformative approaches in functional genomics and chemical biology to overcome these challenges toward new, paradigm-shifting therapies for children with cancer.

PI_NAMEs: STEGMAIER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult;Area;Biology;Cancer Model;career;Caring;Cessation of life;Chemicals;Child;Childhood;Childhood Solid Neoplasm;CRISPR screen;Cytotoxic Chemotherapy;Dedications;Dependence;Disease;Disincentive;Drug Targeting;Ensure;Epigenetic Process;Ewings sarcoma;functional genomics;Fusion Oncogene Proteins;genome-wide;Genomic approach;Goals;Immune checkpoint inhibitor;Immunologist;Immunotherapy;inhibitor;innovation;Laboratories;Lead;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Marketing;Medicine;Molecular;Morbidity - disease rate;Mutation;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Pediatric Oncologist;Pediatric Oncology;Pediatrics;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;programs;protein degradation;Proteins;Radiation;Research Personnel;response;Risk;Role;Sarcoma;School-Age Population;Scientist;Structural Biologist;success;Therapeutic;therapeutic target;therapy development;Time;transcription factor;tumor;Validation;Work

PROJECT_TITLE: Targeting Pediatric Cancer Vulnerabilities


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

PI_NAMEs: MCGRATH, LAUREN M (contact)

PROJECT_TERMS: 17 year old;Address;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Behavioral;Child;Child Mental Health;childhood anxiety;Clinic;Clinical;clinical anxiety;Clinical Research;Cognitive;Collaborations;collaborative approach;Communities;comorbidity;Comprehension;comprehension skill;Cost Analysis;Coupled;design;Development;Differential Diagnosis;executive function;experience;Genetic;Goals;Image;Impairment;insight;Intervention;Knowledge;Learning Disabilities;Learning Disorders;Literature;Longitudinal Studies;Mathematics;Measures;Mental Health;Modeling;Neuropsychology;novel;Panic;peer;Personal Satisfaction;Positioning Attribute;Prevention;processing speed;Publishing;Quality of life;Reading;reading comprehension;reading difficulties;Reading Disabilities;recruit;Research;Resources;Risk;Sampling;Science;Services;skills;social;social anxiety;Specificity;Testing;theories;therapy development;Time;Training;translational potential;Work;Youth

PROJECT_TITLE: Identifying the correlates and trajectory of academic and clinical anxiety symptoms in children with reading disabilities


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Genetic defects in the cohesin complex member Stag2 are recurrently mutated in various human cancers and lead to disruption of tissue-specific gene expression through DNA looping. Using cutting-edge epigenomic techniques, primary patient samples, and a reversible in vivo Stag2 mouse, we will map Stag2-specific chromatin looping in transcriptional regulation of hematopoietic stem and progenitor cells and functionally assess their contribution to the lineage fate and self-renewal. Using these techniques in combination with sequential mutagenesis of the AML driver mutation FLT3ITD, we will determine the effects of altered chromatin structure on leukemogenesis, the requirement of Stag2 for leukemia maintenance, and the effects on therapeutic response.

PI_NAMEs: VINY, AARON D (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acute Promyelocytic Leukemia;Affect;Alleles;AML/MDS;biobank;Biological Assay;Biological Markers;Blood Cells;Bone Marrow;Bone Marrow Stem Cell;cancer subtypes;Cell Lineage;Cells;Charge;chemotherapy;Chromatin;chromatin immunoprecipitation;Chromatin Loop;chromatin remodeling;Chromatin Structure;cohesin;Complex;Credentialing;Cytarabine;Cytotoxic agent;Dependence;Disease remission;Doxorubicin;driver mutation;Dysmyelopoietic Syndromes;Enhancers;Epigenetic Process;epigenomics;Equilibrium;Euchromatin;Event;FLT3 gene;FLT3 inhibition;Functional disorder;Gene Expression;gene regulatory network;Genetic;Genetic Transcription;Genomics;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Heterochromatin;Hi-C;hip replacement arthroplasty;Homeostasis;Human;Impairment;In Vitro;in vivo;inhibitor;innovative technologies;insight;leukemia;Leukemic Hematopoietic Stem Cell;leukemic transformation;leukemogenesis;loss of function;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;member;Mission;Modeling;Molecular Profiling;mouse model;multiple omics;Mus;Mutagenesis;mutant;mutant mouse model;Mutate;Mutation;mutational status;Myelogenous;Myeloproliferative disease;Neighborhoods;new therapeutic target;novel;Output;patient derived xenograft model;Patients;Phenocopy;Phenotype;Play;Population;Prediction of Response to Therapy;prevent;Production;progenitor;programs;recombinase;Recurrence;Regimen;Regulation;Repression;Resources;restoration;Role;Sampling;Secondary acute myeloid leukemia;self-renewal;Serial Passage;stem;stem cell population;stem cell proliferation;stem cell self renewal;Strategic Planning;Structure;Survival Rate;System;targeted treatment;Techniques;Technology;Therapeutic;therapy resistant;Tissue-Specific Gene Expression;transcription factor;Transcriptional Regulation;transcriptome sequencing;Treatment Protocols;treatment response;Tretinoin;tumorigenesis;Validation

PROJECT_TITLE: The role of the cohesin complex in hematopoietic transformation and leukemia maintenance

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Placental dysfunction results from abnormal development of this organ early in gestation, and is the underlying cause of adverse pregnancy outcomes, including miscarriage, preeclampsia, and fetal growth restriction. Pregnancies affected by Trisomy 21 are at high risk of miscarriage and fetal growth restriction, at least partly due to abnormalities of placental development. This project will use placental cells, derived directly from normal and Trisomy 21-affected placentas or pluripotent stem cells in order to identify cellular defects underlying placental dysfunction.

PI_NAMEs: PARAST, MANA M (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;adverse pregnancy outcome;Affect;Basal Plate;Biological Assay;Biological Models;blastocyst;CDX2 gene;Cell Nucleus;cell type;Cells;chorionic plate;Chorionic villi;Complement;cytotrophoblast;Data;Data Set;Defect;Derivation procedure;Development;differentiation protocol;Disease;disease phenotype;Down's Syndrome;Embryo;Environment;Epithelial Cells;Ethics;fetal;Fetal Growth;Fetal Growth Retardation;First Pregnancy Trimester;Functional disorder;Generations;Genetic Models;Goals;Heterogeneity;high risk;Human;human data;human pluripotent stem cell;human stem cells;implantation;In Vitro;in vivo;insight;Karyotype;Knowledge;LGR5 gene;Maintenance;Maternal-Fetal Exchange;Modeling;Molecular;Multiple Pregnancy;Nutrient;Organ;organ growth;Organoids;overexpression;Oxygen;Phenotype;Placenta;Placentation;Play;Pluripotent Stem Cells;Pre-Eclampsia;preference;Pregnancy;Pregnancy Complications;progenitor;Protocols documentation;Reproducibility;Retained Placenta;Risk;Role;Second Pregnancy Trimester;single cell analysis;single-cell RNA sequencing;small hairpin RNA;Sorting;Specific qualifier value;Spontaneous abortion;stem cell differentiation;stem cells;Subgroup;Surface;Syncytiotrophoblast;Third Pregnancy Trimester;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;trophoblast;trophoblast stem cell;Villous

PROJECT_TITLE: Trophoblast progenitor heterogeneity and function in normal and Trisomy 21-affected placentae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-E(90)S]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Disability Research;Mental Health;Neurosciences;Pediatric

PI_NAMEs: BANICH, MARIE T (contact)

PROJECT_TERMS: Achievement;Address;Age;aged;Amygdaloid structure;Anxiety;Area;Back;Brain;Brain region;Characteristics;Child;Collection;comorbidity;Data;Differential Diagnosis;Emotional;Emotions;Enrollment;Etiology;Evaluation;Excision;executive function;experience;Funding;goal oriented behavior;Graph;graph theory;high reward;high risk;in silico;Individual;Individual Differences;Inferior;Inferior frontal gyrus;interest;intraparietal sulcus;Investigation;Lateral;Learning Disabilities;Left;Lesion;lexical;mathematical ability;mathematical difficulties;Mathematics;neural;neural patterning;Neurobiology;neuroimaging;novel;Participant;Pattern;Play;Population;Positioning Attribute;Precentral gyrus;Prefrontal Cortex;Process;Reading;reading ability;reading difficulties;remediation;Research;Rest;Role;Sample Size;Sampling;Short-Term Memory;System;Task Performances;Testing;visual processing;Work;Youth

PROJECT_TITLE: Neuroimaging