NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Patient Safety;Pneumonia;Pneumonia and Influenza

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The current approach to treatment of ventilator-associated pneumonia (VAP)—a common, costly, and highly morbid infection—is inflexible and impersonal. The present approach increases side-effect risk, promotes drug- resistant infections, and under-treats many patients. This project aims to surmount barriers to personalizing VAP antibiotic treatment durations by identifying lung biomarkers that reliably identify cure of infection and creating novel VAP trial outcomes that inform bedside care.

PI_NAMEs: ALBIN, OWEN  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Academy;Address;Adverse drug event;Affect;Alveolar;Antibiotic Therapy;Antibiotics;antimicrobial;Award;Biological;Biological Assay;Biological Markers;biomarker signature;Biometry;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;career;career development;Career Mobility;Caring;Case Study;Clinical;clinical epidemiology;Clinical Investigator;clinical translation;Clinical Trials;Cohort Studies;Colistin;Collection;Combined Modality Therapy;Communicable Diseases;Complex;Consensus;cost;Coupled;Critical Illness;Data;Data Science;Decision Analysis;Decision Making;Dedications;Development Plans;Diagnosis;Drug resistance;Ensure;Epidemiology;extensive drug resistance;Face;Functional disorder;Funding;Future;Goals;Guidelines;Health;Health Care Costs;Hospitalization;improved;Infection;innovation;Internal Medicine;Lung;Manuscripts;Maps;Market Research;Measures;Mediating;Mentors;Methodology;Michigan;Modeling;Morbidity - disease rate;mortality;multi-drug resistant pathogen;Neutrophilia;Nosocomial Infections;Nosocomial pneumonia;novel;Nucleic Acid Amplification Tests;Organ;Outcome;overtreatment;pathogen;Patient-Focused Outcomes;Patients;Peer Review;Performance;Pharmacologic Substance;Pneumonia;pneumonia treatment;Positioning Attribute;predictive marker;preference;Professional Organizations;professor;prospective;Publications;Recommendation;Recurrence;Research;respiratory;Risk;Safety;secondary analysis;Sepsis;Series;side effect;Site;specific biomarkers;standard of care;Survey Methodology;Surveys;Syndrome;Techniques;Testing;tool;Training;treatment duration;treatment effect;Treatment Failure;treatment response;trend;trial design;Universities;ventilator-associated pneumonia;Work

PROJECT_TITLE: Personalizing Antimicrobial Use in Ventilator-Associated Pneumonia

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: Boulder

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative The goal of this application is to develop a new technology platform for delivering proteins and nucleic acids to the intracellular space to alter cellular or organismic phenotypes transiently or permanently in a dose-dependent manner.

PI_NAMEs: LIU, XUEDONG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: adaptive immune response;Address;Antibodies;Area;Basic Science;Biological Products;Biomedical Research;Bypass;CD47 gene;Cell Line;Cell membrane;Cell Nucleus;Cells;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complement;Complement component C1;Cytosol;design;Diffusion;Dose;Effectiveness;Electroporation;Encapsulated;Endosomes;Engineering;Enzymes;Exhibits;exosome;Extracellular Space;extracellular vesicles;Gene Delivery;gene function;Goals;GTP-Binding Proteins;Heterogeneity;Human;human disease;Immune response;immunogenicity;improved;In Vitro;in vivo;innovation;interest;Intracellular Space;Knock-out;macromolecule;Measures;Mediating;Methods;Microinjections;microvesicles;Modification;Molecular Weight;nanobodies;nanoengineering;new technology;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Pathway interactions;Phenotype;Production;protein aggregation;protein degradation;protein function;Proteins;Publishing;Research;Resistance;Ribonucleoproteins;RNA Interference;RNA Sequences;Safety;Specificity;success;Surface;System;systemic toxicity;Technology;technology platform;Testing;Therapeutic;Time;tool;Toxic effect;Transfection;translational medicine;treatment strategy;ubiquitin-protein ligase;vesicular stomatitis virus G protein;Viral

PROJECT_TITLE: Programmable Microvesicles for Intracellular Macromolecule Delivery

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE: Early life adversity predisposes individuals to develop anxiety and mood disorders, which are more prevalent in women than men. Understanding the role of progesterone, allopregnanolone, and estrogen in hippocampal plasticity and function and may provide clues for the creation of new therapies in adults to mitigate vulnerabilities that begin early in life.

PI_NAMEs: GOULD, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Adult;Affect;Allopregnanolone;antagonist;Anterior;Anxiety;Anxiety Disorders;avoidance behavior;Behavior;Behavioral;Binding;Buffers;Cells;comparison control;confocal imaging;Diagnosis;Diestrus;early life adversity;Electrophysiology (science);Emotional;Enzyme-Linked Immunosorbent Assay;Estradiol;Estrogens;Estrous Cycle;Exhibits;experimental study;Extracellular Matrix;Female;Frequencies;Functional disorder;Funding;Gene Expression;Genes;Goals;Hippocampus;Hormonal Change;Human;Impairment;improved;In Situ Hybridization;in vivo;Individual;Interneurons;Knowledge;Life;Link;male;Mass Spectrum Analysis;maternal separation;Measures;Memory;memory consolidation;men;Menopause;Mood Disorders;Mus;Neurons;neurosteroids;novel therapeutics;Parvalbumins;pharmacologic;Postpartum Period;Proestrus;Progesterone;Progesterone Receptors;Progress Reports;Puberty;receptor;receptor expression;Resolution;Risk;Rodent;Role;sex;Signal Transduction;social;spatial memory;steroid hormone;Steroids;Structure;Synaptic Receptors;Testing;Time;Transgenic Mice;Viral;Weaning;Woman;Women's prevalence

PROJECT_TITLE: Investigating steroid hormones, neurosteroids, and perineuronal nets in early life adversity-induced changes in hippocampal function

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Teenage Pregnancy;Women's Health Research

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Adolescent females detained or on probation in juvenile justice settings present with a unique health risk profile, including elevated risk of unplanned pregnancy, substance use, HIV/STI infection, and the overlapping risk of substance-exposed pregnancy. This study will test the efficacy of a targeted bundled prevention intervention for this vulnerable population, many of whom are ethnic minorities disproportionately at risk.

PI_NAMEs: PARRISH, DANIELLE ELIZABETH (contact);VON STERNBERG, KIRK

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Address;Adolescent;adolescent woman;Adult women;Affect;Alcohol consumption;alcohol exposure;alcohol risk;alcohol risk reduction;Alcohols;Behavior;behavior change;Behavior Therapy;Behavioral;Cognitive;Communities;Conceptions;condoms;consistent condom use;Criminal Justice;design;Development;Diversion Program;efficacy evaluation;efficacy testing;efficacy trial;ethnic minority;Ethnic Origin;Female;Female Adolescents;Female of child bearing age;follow-up;Gender;Goals;Health;Health behavior change;high risk;High Risk Woman;HIV;improved;Individual;Infection;infection risk;Informal Social Control;Intervention;Journals;Justice;juvenile justice system;Low Prevalence;male;Marijuana;marijuana cessation;marijuana use;Mediating;Mediator;Minority;Mobile Health Application;Motivation;motivational enhancement therapy;Nature;nicotine use;peer;Pilot Projects;Population;post intervention;Pregnancy;pregnant;prevent;preventive intervention;probation;Process;programs;Public Health;Race;racial diversity;racial population;Readiness;Recording of previous events;reduced alcohol use;Reporting;Research;Risk;Risk Behaviors;Risk Reduction;Services;sexual risk behavior;sexually active;Sexually Transmitted Diseases;skills;societal costs;standard care;substance use;substance use prevention;Teenagers;Testing;Theoretical model;therapy design;Time;Tobacco;Underserved Population;unintended pregnancy;Vulnerable Populations;web site;Woman;Work;young woman;Youth

PROJECT_TITLE: CHOICES-TEEN: Efficacy of a Bundled Risk Reduction Intervention for Juvenile Justice Females

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: At least 85% of colorectal cancer (CRC), the 2nd most frequent cause of cancer deaths worldwide, is due to microsatellite stable (MSS) CRC, which does not respond to immune checkpoint blockade (ICB), in contrast to microsatellite unstable (MSI-H), in which durable remissions are achieved with ICB. By combing single-cell RNA- sequencing (scRNA-seq), regional whole exome sequencing (WES), spatial transcriptomics (ST) and MxIF to enumerate consensus cell states and to project tumor programs and microenvironmental features onto progression pseudotime, we have identified an immune-exclusion IEX score in MSS CRC that consists of DDR1, TGFBi and DPEP1, which are markedly upregulated in plasma-derived small extracellullar vesicles (sEVs) and supermeres of CRC patients compared to healthy controls, and for which inhibitors are developed or being developed. In this R35 renewal, we propose to explore mechanisms by which these proteins promote tumorigenesis, develop them as liquid biomarkers, and introduce novel strategies to introduce inhibitors to them in the clinic.

PI_NAMEs: COFFEY, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Area;Biogenesis;Biological Markers;Biology;cancer biomarkers;Cancer Etiology;Cell Communication;Cells;Cessation of life;Clinic;Clinical;clinical implementation;Clinical Trials;colon cancer patients;Colonic Neoplasms;Colorectal Cancer;Colorectal Neoplasms;Consensus;DDR1 gene;Diagnosis;Disease remission;Embryonic Development;epithelial stem cell;Event;Exclusion;exome sequencing;extracellular vesicles;Funding;Genes;Immune;immune checkpoint blockade;immunoregulation;inhibitor;intestinal homeostasis;Investigation;Liquid substance;Malignant Neoplasms;Microsatellite Repeats;mortality;Mus;nanoparticle;neutralizing antibody;novel;novel marker;novel strategies;Outcome;overexpression;Plasma;Population;programs;protein function;Protein Isoforms;Protein Secretion;Proteins;Role;Seminal;single-cell RNA sequencing;Solid Neoplasm;stem;stem cell population;stem cells;Technology;Therapeutic;Thinking;transcriptomics;tumor;tumor microenvironment;tumor progression;Tumor-Derived;tumorigenesis;Vesicle

PROJECT_TITLE: Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Cannabis and cannabis-derived products are reported to be commonly used as sleep aids, yet little is known about the chronic effects of cannabis use on circadian rhythms and sleep architecture, or risk for developing cannabis use disorder (CUD). This proposal will use a rodent model and human postmortem brain tissue to investigate the molecular mechanisms underlying the bidirectional relationship between circadian rhythms and cannabis use. A better understanding of these relationships will not only provide insights into the neurobiology of cannabis use, but also the identification of novel therapeutic targets and treatment strategies for both CUD and sleep disorders.

PI_NAMEs: KETCHESIN, KYLE  (contact);SENEY, MARIANNE L;TORREGROSSA, MARY M

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Affect;Autopsy;Behavior;Behavioral;Brain;brain tissue;cannabinoid administration;Cannabinoids;Cannabis;cannabis withdrawal;Cell Nucleus;cell type;Cessation of life;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Consumption;Corpus striatum structure;Coupled;Development;Disease;Diurnal Rhythm;Electroencephalography;Endocannabinoids;Feedback;Gene Expression;Genes;Genetic Transcription;Health;Hour;Human;innovation;insight;Intake;knock-down;Legal;Link;Long-Term Effects;Maps;marijuana use;marijuana use disorder;Measures;Mediating;Modeling;Molecular;molecular clock;Neurobiology;Neurons;new therapeutic target;Nucleus Accumbens;Pattern;Peripheral;Play;Rattus;Regulation;relapse risk;Reporting;Rewards;Risk;RNA;Rodent;Rodent Model;Role;Self Administration;Series;single nucleus RNA-sequencing;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;Sleeplessness;Specificity;substance use;Substance Use Disorder;System;Testing;Time;time use;transcriptome;translational study;treatment strategy;trend;Viral

PROJECT_TITLE: Investigating the bidirectional relationship between circadian rhythms and cannabinoid use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The improving Health and Housing Outcomes through a Simulation and Economic (iHOUSE) Model is an agent-based model simulating the dynamic processes contributing to HIV incidence, overdose , and life expectancy among people along the housing and homelessness continuum of care in Denver, CO and San Francisco, CA. The project will use a Group Model Building process to engage community stakeholders in the scientific process and inform the structure of the model. The iHOUSE Model will be used to investigate potential combinations of HIV and substance use service delivery programs that are most beneficial for improving health outcomes at various steps in the housing continuum, how those compare to a housing- centered strategies, and their effectiveness at reducing racial/ethnic health disparities.

PI_NAMEs: BAROCAS, JOSHUA ADAM (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Affect;Age;AIDS prevention;American;Black Populations;Black race;care delivery;Cities;Communities;community engaged research;community engagement;Continuity of Patient Care;cost;cost effective;COVID-19 pandemic;Data Set;Development;Disparity;disparity reduction;Drug usage;Economic Factors;Economic Models;Economics;Effectiveness;Environmental Risk Factor;Epidemic;Epidemiology;ethnic disparity;ethnic health disparity;Ethnic Population;evidence base;experience;General Population;Goals;Health;health disparity;health outcome disparity;High Prevalence;HIV;HIV diagnosis;Homeless persons;Homelessness;Housing;housing instability;improved;Incidence;Inequity;injection drug use;innovation;insight;Institution;Intervention;Knowledge;Laboratories;Life Expectancy;Lived experience;Locales;Mental disorders;Mental Health;model building;Modeling;models and simulation;Municipalities;Native Americans;Outcome;outreach;Overdose;Overdose reduction;personalized approach;Persons;Population;Process;programs;racial disparity;racial health disparity;racial population;randomized trial;Resources;Risk;San Francisco;service delivery;Services;simulation;Sociology;structural determinants;Structural Racism;Structure;substance use;Substance Use Disorder;Suicide;syndemic;System;Testing;Time;Trauma;United States;Work

PROJECT_TITLE: Improving Health and Housing Outcomes through a Simulation and Economic Model (iHOUSE Model)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: American Indian or Alaska Native;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Biliary atresia and primary sclerosing cholangitis are conditions that can progress to end-stage liver disease requiring liver transplantation to avoid death in approximately 50% of affected children, as effective treatments aimed at the underlying etiology do not exist. Liver transplantation requires significant public health resources including the generosity of donors, complex multi-disciplinary medical research teams, and significant amounts of finances to be successful. Additional research is needed to understand pathophysiology and treatment targets for these diseases, to minimize the progression to liver transplantation or death.

PI_NAMEs: VALENTINO, PAMELA  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Alagille Syndrome;Alaska;Alaska Native;Alaska Native population;alpha 1-Antitrypsin Deficiency;American Indians;Ancillary Study;Asian;Bile Acids;Biliary Atresia;biobank;Biological;biomedical referral center;Caring;Cell Line;Censuses;Cessation of life;Child;Childhood;Cholestasis;chronic liver disease;Clinic;clinical center;Clinical Research;clinically relevant;Collaborations;Collection;Complement;Complex;Conceptions;Data;Data Analyses;Data Collection;data repository;Development;Diagnosis;Disease;diversity and inclusion;DNA;effective therapy;Elements;end stage liver disease;Enrollment;Ensure;ethnic diversity;Etiology;Exclusion Criteria;experience;follow-up;Functional disorder;Funding;Future;Genetic;Genotype;Geographic Locations;Hawaii;Hawaiian;Health Resources;high standard;Idaho;inclusion criteria;Investigation;Knowledge;Learning;Link;Liver;Liver diseases;liver transplantation;Logic;Longitudinal cohort;Medical Research;meetings;Mission;Mitochondria;Montana;multidisciplinary;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Native-Born;Oregon;Outcome;Pacific Northwest;Participant;participant enrollment;Pathogenesis;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Pediatric Research;Pediatrics;Persons;Pharmacologic Substance;Phenotype;Population;Population Heterogeneity;Positioning Attribute;Prevalence;primary sclerosing cholangitis;Principal Investigator;Productivity;programs;Progressive intrahepatic cholestasis;Protocols documentation;Public Health;rare condition;recruit;Recruitment Activity;repository;Research;Research Personnel;research study;Resources;Role;Scientific Advances and Accomplishments;Seasons;Site;socioeconomics;Specimen;Time;Translational Research;United States;virtual;Washington;young adult

PROJECT_TITLE: Continuation of the Childhood Liver Disease Research Network - Seattle Clinical Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (M1)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: OVERALL PROJECT NARRATIVE Climate change greatly increases the risk that new viral diseases will spillover from animals into people, and it greatly increases the spread of diseases carried by ticks or mosquitoes to new areas. Preventing the outbreak of disease before it occurs is the best way to protect the public’s health. Working in both South Africa and New York State with vulnerable rural communities who are most at risk, we propose to integrate social, biological and climate data into models that can predict when outbreaks occur, so that we can design interventions to prevent them.

PI_NAMEs: OOSTHUIZEN, MARINDA CATHARINA;TRAVIS, ALEXANDER J (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Advisory Committees;African;Anaplasma;animal data;Animals;Arboviruses;Area;Artificial Intelligence;Behavior;Biological;burden of illness;Cessation of life;Chiroptera;Climate;climate change;climate data;climate impact;climate-related health;Communicable Diseases;Communication;Communities;community based participatory research;community engaged research;community engagement;community partners;community partnership;comparative;Complex;cost effective;Coxiella;Culicidae;Data;data modeling;Data Set;data sharing;Deforestation;Dimensions;Discipline;Disease;Disease Outbreaks;diverse data;doctoral student;Economics;Elements;emerging virus;Ensure;Environment;epidemiological model;Epidemiology;Equity;Evolution;Family;feasibility testing;Filovirus;Foundations;Funding Mechanisms;Future;Future Generations;genome sequencing;genomic data;Genomics;Geography;Goals;graduate student;Grant;Health;health data;health knowledge;Health Promotion;Healthcare Systems;Human;human data;Human Resources;improved;Incidence;Infection;infection risk;infectious disease model;Infectious Diseases Research;Institution;land use;Language;Lead;Leadership;Long-Term Effects;Malaria;Mediating;meetings;member;Modeling;mosquito-borne;New York;novel;novel virus;Occupational activity of managing finances;outbreak concern;Outcome;pathogen;pathogen genomics;pathogen spillover;pathogenic virus;Persons;Policies;Policy Maker;Populations at Risk;Postdoctoral Fellow;predictive modeling;preference;Preparation;prevent;prevent outbreaks;preventive intervention;Primary Prevention;Public Health;Records;remote sensing;Research;Research Personnel;Research Proposals;Resources;response;Rickettsia;Risk;Rural Community;Science;Scientist;Shapes;skills;social;social determinants;socioeconomics;South Africa;spillover event;Strategic vision;Stress;Surveys;System;Testing;therapy design;tick-borne pathogen;Ticks;Training;Training Programs;Translating;transmission process;Universities;usability;vector;Vector-transmitted infectious disease;Viral;Virus Diseases;Virus Shedding;Water;whole genome;Woman;Work;Zimbabwe;Zoonoses;zoonotic spillover

PROJECT_TITLE: Center for Transformative Infectious Disease Research on Climate, Health and Equity in a Changing Environment (C-CHANGE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

PI_NAMEs: TRAVIS, ALEXANDER J (contact)

PROJECT_TERMS: Administrative Efficiency;Administrator;Advisory Committees;Africa;Animals;Australia;Climate;climate change;climate impact;climate-related health;Collaborations;Communicable Diseases;Communication;Communities;community based research;community engaged research;community engagement;community involvement;community organizations;community partners;Consensus;Data;data modeling;Decision Making;design;Development;Discipline;Disease Outbreaks;Ensure;Environment;epidemiological model;Equity;Event;Faculty;feasibility testing;Funding;Future;genomic data;Geography;Goals;Government;graduate student;Grant;Health;health equity;Human;Human Resources;Individual;Infection;Infectious Diseases Research;Institution;International;Laboratories;land use;Lead;Leadership;Learning;Link;Medicine;meetings;Methodology;Mission;Modeling;New York;next generation;Office of Administrative Management;operation;Outcome;pathogen genomics;Performance;Persons;Policy Maker;Postdoctoral Fellow;predictive modeling;prevent;preventive intervention;Primary Prevention;Private Sector;Process;Productivity;professional students;programs;Publications;Research;Research Design;Research Personnel;Resources;response;Risk;Role;Running;Rural Community;Science;Scientist;Self-Examination;skills;social;South Africa;Structure;Testing;Training Programs;Translations;transmission process;Underrepresented Populations;United States National Institutes of Health;Universities;vector;virtual;Washington;Work;Zimbabwe


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Prevention;Social Determinants of Health

PI_NAMEs: PLOWRIGHT, RAINA  (contact)

PROJECT_TERMS: Affect;Australia;Automobile Driving;Behavior;Buffers;Chiroptera;Climate;climate change;climate-related health;cost effective;Coupled;Data;data integration;Data Set;data-driven model;Diet;Disease;Dryness;emerging pathogen;Environment;environmental change;Equity;evidence base;explainable artificial intelligence;Family;Filoviridae Infections;Floods;Food;food resource;food shortage;Future;Geographic Locations;Goals;Habitats;Health;health data;High Prevalence;Hormones;Human;human morbidity;human mortality;immune health;Infection;Infectious Diseases Research;innovation;insight;Intervention;Lead;Link;Methodology;Methods;microbiome;Modeling;Movement;multilevel analysis;novel;pathogen;pathogen spillover;Pattern;Physiological;Prevalence;prevent;Prevention;preventive intervention;progenitor;Rain;Recording of previous events;remote sensing;Research Priority;Resolution;Resources;Risk;Role;Running;Sampling;Seasons;Source;South Africa;South Australia;Spatial Behavior;spatiotemporal;spillover event;Surface;Temperature;Testing;Time;Viral;Virus;Virus Diseases;Virus Shedding;Work;Workplace;World Health Organization;Zoonoses;zoonotic spillover


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Social Determinants of Health;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: GOODMAN, LAURA BRUNENGRABER (contact)

PROJECT_TERMS: acaricide;Acute;Affect;Africa;Anaplasmosis;Animals;Arboviruses;Automobile Driving;Babesiosis;Back;Behavior;behavioral response;Biological;Biological Models;Biology;Canis familiaris;Climate;climate change;Collaborations;Communicable Diseases;Communities;community based research;community engagement;community intervention;community partners;Community Practice;Complex;Data;data modeling;Data Sources;demographics;detection method;Development;Diagnostic;diagnostic development;Disease;disease transmission;disorder prevention;driving force;efficacy testing;Environment;environmental change;Epidemiology;Equity;Fever;Formulation;Foundations;Funding;Future;genome sequencing;Genomics;Geography;Health;health record;Human;improved;Infectious Diseases Research;insight;International;Intervention;Laboratories;Link;Livestock;Malaria;malaria transmission;microbiome;Modeling;Molecular;mosquito-borne;Mosquito-borne infectious disease;mosquito-borne pathogen;Natural Selections;New York;novel;Parasitology;pathogen;pathogen genome;pathogen genomics;Pathway interactions;Patients;Pattern;Persons;Play;Policy Making;predictive modeling;Prevalence;programs;Province;Public Health;Rain;Records;remote control;remote sensing;Research Project Grants;response;Risk Factors;Role;Sentinel;Shapes;Site;Social Conditions;socioeconomics;Source;South Africa;Specimen;System;Techniques;Technology;Testing;therapeutic development;Tick-Borne Diseases;tick-borne pathogen;Ticks;transmission process;trend;Universities;vector;vector competence;vector control;Vector Ecology;vector transmission;Vector-transmitted infectious disease;Virus;Vulnerable Populations;Washington;Water;whole genome;Zoonoses

PROJECT_TITLE: Project 2 - Center for Transformative Infectious Disease Research on Climate, Health and Equity in a Changing Environment (C-CHANGE)


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Prevention;Social Determinants of Health;Vector-Borne Diseases

PI_NAMEs: MEREDITH, GENEVIVE  (contact)

PROJECT_TERMS: Action Research;Address;Animals;Applied Research;Behavior;Border Community;Chiroptera;Climate;climate change;climate impact;climate-related health;Communicable Diseases;Communication;Communities;Community Actions;community based participatory research;community engaged research;community engagement;Community Health;community partners;community research;Complex;Data;Data Set;data sharing;Development;Disease;Disease Outbreaks;disease transmission;disorder prevention;disorder risk;Documentation;Ensure;Environment;epidemiological model;Equity;Evaluation;Evolution;experience;Fostering;Funding;Future;Generations;Goals;Grant;hazard;Health;Human;implementation facilitation;improved;Infectious Diseases Research;innovation;interest;land use;Language;Leadership;Link;Malaria;Mediating;member;Methods;Modality;Modeling;Mosquito-borne infectious disease;New York;Outcome;Output;pathogen genomics;pathogenic virus;Personal Satisfaction;Persons;preventive intervention;Process;professional atmosphere;programs;promote resilience;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;resilience;Resources;response;Risk;scientific literacy;Shapes;skills;social;Solid;South Africa;spillover event;Structure;System;Testing;tick-borne;Training;Translating;Trust;Universities;vector;Vector-transmitted infectious disease;Viral;Work;Zimbabwe


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: HAYDEN, ALISTAIR  (contact)

PROJECT_TERMS: Acceleration;Achievement;Air Pollution;analytical tool;Animals;Artificial Intelligence;artificial intelligence method;Behavior;biobank;Biological Models;Biology;career;Climate;climate change;climate impact;Collaborations;Communicable Diseases;community engagement;Complex;computer science;Computer software;Computers;Coupled;Data;Data Analyses;data curation;data integration;data library;data management;data modeling;Data Set;Data Storage and Retrieval;data streams;Databases;Development;Discipline;Disease;disease model;Disease Outbreaks;disease transmission;diverse data;Ecology;Econometric Models;econometrics;Ecosystem;Ensure;Environment;epidemiological model;Epidemiology;Equity;experience;federated database;flexibility;Fostering;genomic data;Genomic Library;Geographic Locations;Geography;Goals;Health;health data;High Performance Computing;Human;Human Biology;improved;Individual;Infectious Diseases Research;Informatics;Institution;interdisciplinary collaboration;Knowledge;Laboratories;land cover;Link;Machine Learning;mathematical model;Mathematics;member;Methods;Modeling;Modernization;novel;novel strategies;Participant;pathogen genomics;Pathway interactions;Physics;Pilot Projects;Policy Analysis;predictive modeling;remote sensing;Research;research facility;Resolution;Sampling;Seasons;skills;Social Sciences;South Africa;spatiotemporal;statistics;System;systematic review;Terminology;Testing;theories;Time;tool;Training;United States;Universities;vector;Work;Zimbabwe


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Drug abuse is an enormous public health challenge; human genetics studies have identified a significant genetic contribution to the risk of developing drug abuse. Rodent genetic studies are vital to understanding the molecular genetic basis of drug abuse, but are hampered by an incomplete catalogue of potentially causative genetic variants. In this project, we will examine two important but understudied sources of genetic variation: structural variants and tandem repeats.

PI_NAMEs: GYMREK, MELISSA ;PALMER, ABRAHAM A (contact);SEBAT, JONATHAN

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Addictive Behavior;Address;autism spectrum disorder;Behavioral;behavioral phenotyping;Bioinformatics;Bipolar Disorder;Catalogs;causal variant;cohort;Communities;Complex;computerized tools;Computing Methodologies;Data;Data Set;Drug abuse;Gene Expression;Genetic;Genetic Polymorphism;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;genomic locus;Genotype;Height;Heritability;Human;Human Genetics;Human Genome;Hybrids;Inbred Mouse;Inbred Strain;Inbred Strains Rats;Inbreeding;Leadership;Malignant Neoplasms;Methods;model organism;Molecular Genetics;mouse genome;Mouse Strains;Mus;Mutation;nanopore;novel sequencing technology;Phenotype;Play;Population;Population Study;Public Health;Publishing;rat genome;Rattus;Recombinant Inbred Strain;Resources;Risk;Rodent;rodent genome;Role;Schizophrenia;Signal Transduction;single molecule;Single Nucleotide Polymorphism;Source;Surveys;Tandem Repeat Sequences;Technology;technology platform;trait;Variant;whole genome

PROJECT_TITLE: Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and Rats


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing technologies to diagnose people with abnormal bleeding. Once such technologies have been developed, there is the potential to better define origins of disease and responses to drugs. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to seeking fundamental knowledge about the nature of living systems.

PI_NAMEs: MAGIN, CHELSEA M;NEEVES, KEITH B (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute;Address;Adhesions;Adhesives;Bar Codes;Biochemical;Biological Assay;Biomechanics;Biomedical Engineering;Blood Cell Count;Blood Coagulation Disorders;Blood flow;Blood Platelet Disorders;Blood Platelets;Chronic;Classification;Clinical;clinical translation;combinatorial;Consultations;Defect;design;Diagnosis;Diagnostic;diagnostic assay;diagnostic criteria;diagnostic strategy;Disease;Elasticity;Elements;Emulsions;Engineering;Equilibrium;Event;Exclusion;experimental study;Flow Cytometry;Goals;Health Services Accessibility;Heart Diseases;Heart Research;Hematological Disease;hemodynamics;Hemorrhage;Hemostatic Agents;Hydrogels;Immobilization;improved;in vivo;Individual;Inflammation;Inherited;innovation;Insurance Coverage;Kinetics;Knowledge;Laboratories;Ligands;light transmission;Lung Diseases;Measurement;Measures;mechanotransduction;Methods;Microfluidics;Microscopy;Mission;Nature;Newly Diagnosed;Nucleosome Core Particle;Optics;Organism;particle;Pattern;Peptide Synthesis;Perfusion;Persons;Pharmaceutical Preparations;Phase;Physiology;platelet function;Platelet Function Tests;Polyethylene Glycols;Process;Public Health;Quantum Dots;Reproducibility;Research;response;screening;Site;Sleep Disorders;Specialist;Specificity;Speed;Standardization;Stimulus;Surface;Suspensions;Techniques;Technology;technology platform;Testing;Thrombelastography;United States National Institutes of Health;Variant;Vertebral column

PROJECT_TITLE: Engineering a lab-on-a-particle platform to measure platelet function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

PHR: PROJECT NARRATIVE People with HIV (PWH) use cannabis more than the general population, but its potential beneficial/negative effects on the brain have not been investigated. Here, we will determine whether cannabis has beneficial or negative effects on cognitive functions strongly linked to HIV risk behaviors in PWH compared with healthy participants. We will then utilize an animal model of HIV to determine the directionality of effects of acute and chronic administration, withdrawal from such cannabinoid treatments, as well as effects of antiretroviral therapy using consistent behavioral tests.

PI_NAMEs: MINASSIAN, ARPI  (contact);YOUNG, JARED WILLIAM

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Adult;adverse outcome;Affect;anandamide;Animal Experimentation;Animal Model;Animals;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Area;Attenuated;Behavior;behavior test;Behavioral;Biological;Biological Assay;Biological Markers;Brain;Brain region;Cannabidiol;cannabinoid administration;cannabinoid treatment;Cannabinoids;Cannabis;cannabis administration;Cannabis policy;cannabis withdrawal;Chronic;Clinical Research;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive function;cognitive process;cognitive testing;comorbidity;Complex;Corpus striatum structure;Decision Making;Desire for food;Disease;Disease Progression;Disinhibition;Dopamine;Dopamine Receptor;dopamine system;Dose;Endocannabinoids;endogenous cannabinoid system;excitotoxicity;Exhibits;exogenous cannabinoid;experimental study;Feedback;follow-up;Formulation;General Population;Harvest;High Prevalence;HIV;HIV risk;HIV-1;Homovanillic Acid;Human;Human immunodeficiency virus test;improved;inattention;Individual;insight;Knowledge;Learning;Lifting;Limbic System;Link;marijuana use;marijuana user;Mediating;Medicine;Modeling;Moods;Motivation;Nausea;neurobiological mechanism;Neurobiology;neurochemistry;Neurocognitive Deficit;neuroprotection;Neurotransmitters;nonhuman primate;Oral;pain relief;Participant;Perception;Persons;Pharmaceutical Preparations;Pharmacology;Placebos;Policies;Population;Prefrontal Cortex;Prevalence;Property;Randomized;Rat Transgene;Rattus;receptor expression;Recommendation;Recreation;remediation;response;Rewards;Risk;Risk Behaviors;Risk Taking;Rodent Model;Role;Severity of illness;Statistical Data Interpretation;substance use;Symptoms;System;Testing;Tetrahydrocannabinol;Therapeutic;therapeutic development;Time Perception;Training;Transgenic Organisms;translational study;transmission process;Viral Load result;Virus;Withdrawal

PROJECT_TITLE: Translational Studies of Cannabis Administration, Cognition, and the Endocannabinoid System in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE: Interrogating the cholinergic basis of opioid use disorder Here, we propose to develop, characterize, and deploy a comprehensive toolset focused on opioid neuropharmacology. We will test the hypothesis that μORs on cholinergic interneurons mediate harmful effects of opioids, independent of therapeutic analgesic effects. The proposed technologies will offer the unprecedented opportunity to establish causal behavioral roles of opioid neuropharmaceuticals mediated by defined cell types.

PI_NAMEs: TADROSS, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Absence of pain sensation;Acute;Address;Adjuvant Therapy;Adoption;Affect;Analgesics;Animals;anxiety treatment;Axon;Behavior;Behavioral;brain volume;Buprenorphine;Catalogs;cell type;Cells;Chemicals;cholinergic;Cholinergic Agents;Clinical;clinical efficacy;Clinical Trials;clinically relevant;cognitive enhancement;Communities;design;Development;Dissociation;Dopamine;Dose;double-blind placebo controlled trial;drug action;Experimental Designs;experimental study;Foundations;Galantamine;Genetic;In Vitro;in vivo;Incidence;Infusion procedures;insight;Interneurons;Knowledge;Ligands;Literature;Locales;Maps;Mediating;Mental Depression;Methadone;Methods;Modeling;mu opioid receptors;Mutation;Naloxone;Neuropharmacology;Neurosciences;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;opioid use;opioid use disorder;overexpression;Oxymorphone;Pain management;Pharmaceutical Preparations;Pharmacology;Psychoses;Publishing;Reagent;receptor;Relapse;Risk;risk minimization;Rodent Model;Role;Science;side effect;Signal Transduction;Specificity;Substance Use Disorder;System;Technology;Testing;theories;Therapeutic;Time;tool;Validation;Work


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative This project aims to identify the relationships between genetically-defined subpopulations of cells in the brain and the functional roles they play in opioid self-administration. This is likely to provide insight into the neural basis of drug addiction and identify possible therapeutic targets for future studies.

PI_NAMEs: SJULSON, LUCAS L (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Autopsy;Brain;brain tissue;cell type;Cells;Drug Addiction;Electrophysiology (science);epigenomics;Future;Gene Expression Regulation;Human;in situ sequencing;in vivo;innovation;insight;Label;Link;Methods;multiphoton imaging;Mus;neural;Neurons;new therapeutic target;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Optical Methods;optogenetics;Oral;Phase;Play;Role;Self Administration;Substance Use Disorder;Techniques;therapeutic target;transcriptomics

PROJECT_TITLE: Uncovering links between neuronal transcriptomic and functional profiles in opioid addiction


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: The proposed research will investigate the impact of THC on extracellular vesicle signaling in the brain and periphery. It is predicted that extracellular vesicles will contain differential profiles of cargo in response to varying THC exposures and in the presence of nicotine co-exposure. By providing fundamental insights into novel extracellular mechanisms with THC, findings from these studies may thereby identify biomarkers and targets for the development of efficacious therapeutics to treat dependence in humans.

PI_NAMEs: FOWLER, CHRISTIE D (contact)

PROJECT_TERMS: Abstinence;Acute;Adipocytes;Alleles;Biological Markers;biomarker identification;biomarker panel;Blood;Brain;Brain region;cannabinoid receptor;Cannabinoids;Cannabis;CD81 gene;cell type;Cerebrospinal Fluid;Choroid Plexus Epithelium;Chronic;Cigarette;clinical application;CNR1 gene;CNR2 gene;Cre driver;Data;density;Dependence;Development;Disease;Dopamine;Dopaminergic Cell;dopaminergic neuron;Drug Addiction;drug of abuse;Drug usage;Epithelial Cells;extracellular;extracellular vesicles;Female;Foundations;Genetic Transcription;genome wide association study;Goals;Human;Hypermethylation;In Vitro;in vivo;Individual;innovation;insight;integration site;male;Malignant Neoplasms;marijuana use;marijuana user;Mediating;MicroRNAs;Microscopy;Mus;NCAM1 gene;neural;Neural Cell Adhesion Molecules;Neuroglia;Neurons;new therapeutic target;Nicotine;nicotine exposure;nicotine self-administration;novel;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Plasma;Population;promoter;Property;Rattus;receptor;receptor expression;Research;Resistance;response;Rewards;RNA;sex;Signal Transduction;specific biomarkers;Structure of choroid plexus;Surface;Tetrahydrocannabinol;THC exposure;Therapeutic;therapeutic development;Tissues;Tobacco use;transcriptome sequencing;Transgenic Mice;uptake;Validation;Variant;Ventral Tegmental Area;vesicular release;Virus

PROJECT_TITLE: Impact of THC on Extracellular Vesicle Signaling


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Adolescents in residential substance use treatment have high risk of relapse after discharge, but it is extremely difficult to engage these adolescents and their parents in continuing care. This study aims to improve the outcomes of adolescents following discharge from residential substance use treatment by offering their parents a novel technology-assisted intervention. Technology-assisted interventions have the potential for marked public health impact by extending the reach, duration, and scalability of evidence-based care.

PI_NAMEs: BECKER, SARA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent binge drinking;adolescent substance use;Behavioral;binge drinking;Caring;Child Rearing;Clinical Trials;Communication;computer program;computerized;Controlled Environment;Data;design;Development;Distal;Drug usage;Effectiveness;effectiveness evaluation;Evaluation;evidence base;Exhibits;experience;externalizing behavior;Family;follow up assessment;Follow-Up Studies;Funding;Goals;high risk;high risk sexual behavior;improved;improved outcome;in vivo;Intervention;Legal;Measurement;Measures;Mediating;Mediator;Methods;Mind;Modeling;Monitor;Motivation;National Institute of Drug Abuse;new technology;Notification;Outcome;parent-adolescent communication;parental monitoring;parenting intervention;Parents;Patient Self-Report;pilot trial;Problem behavior;Process;psychologic;Public Health;Randomized;Recommendation;Relapse;relapse risk;Research;Residential Treatment;Risk;Schools;skills;substance misuse;substance use;Substance Use Disorder;substance use treatment;Technology;telehealth;Testing;Time;treatment as usual;treatment center;Truancy;Underserved Population;Urine;Vocation;Youth

PROJECT_TITLE: Improving Outcomes of Adolescents in Residential Substance use Treatment via a Technology-Assisted Parenting Intervention

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Most young adult (<30 years old) people who inject drugs (PWID) –who are the group at greatest risk for hepatitis C virus (HCV) infection—do not initiate available curative therapy. Building on our extensive foundation of dyadic research and dyadic behavior change theories, we developed the Partner Navigation Intervention a two-session injecting partnership intervention to enhance dyadic capacity for HCV treatment initiation for young adult PWID. The proposed study is a randomized controlled study (RCT) to assess the efficacy and mechanism of action of the first behavioral intervention to increase HCV treatment initiation among young adult PWID.

PI_NAMEs: MORRIS, MEGHAN D (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: acceptability and feasibility;Action Potentials;Address;Adult;Affect;Age;Behavior;behavior change;Behavior Therapy;Clinical;clinical diagnosis;cohort;Communities;community advisory board;comparison intervention;Control Groups;Counseling;County;curative treatments;Data;design;Diagnosis;Discrimination;Dissemination and Implementation;distrust;efficacy evaluation;efficacy testing;Emotional;Epidemic;Evidence based program;experience;Family;Foundations;Friends;Goals;group intervention;Health;Health behavior;Health behavior and outcomes;Health Promotion;Health Resources;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Homelessness;improved;indexing;Individual;Infection;Injecting drug user;Intervention;Intervention Studies;intimate behavior;Maps;marginalization;Medical;member;novel;opioid epidemic;Paper;Partnership Practice;Personal Satisfaction;Persons;Population;Poverty;Prevention;Probability;Professional counselor;programs;Randomized;randomized trial;randomized, controlled study;Records;Research;response;Risk;Role;Safety;San Francisco;Site;social;Social Network;social relationships;Social support;standard of care;success;System;Testing;Theory of Change;Time;timeline;tool;Translating;Trust;United States;Visit;Work;young adult

PROJECT_TITLE: A Randomized Trial to Test the Efficacy of a Partner Navigation Intervention for HCV Treatment among Young Adult People who Inject Drugs

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Established smoking cessation medications effectively treat withdrawal symptoms but do little to address the powerful influence that cues and contexts have on smoking behavior. Across both basic and clinical research, β-adrenergic medications have demonstrated potential to reduce these influences by disrupting the key cognitive processes that unfold when smoking cues and contexts are encountered. This project will use neuroimaging to determine the effects of these medications on brain responses to smoking cues and contexts in human cigarette smokers, providing vital information on the mechanisms responsible for their effect and informing further treatment development efforts.

PI_NAMEs: OLIVER, JASON ANTHONY (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;addiction;Address;Adjuvant Analgesic;Adjuvant Therapy;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adult;Amygdaloid structure;Attention;Attenuated;Automobile Driving;Award;Basic Science;Behavior;Behavioral;Behavioral Mechanisms;behavioral response;beta-adrenergic receptor;Brain;Brain region;cerebrovascular;Cerebrovascular Circulation;Cessation of life;Cigarette;Cigarette Smoker;cigarette smoking;Clinical;Clinical Research;cognitive control;cognitive process;craving;Crossover Design;cue reactivity;Cues;design;Development;drug development;Drug Modulation;Drug Targeting;Drug usage;Emotional;Exposure to;Follow-Up Studies;functional MRI scan;Future;Goals;Health Personnel;Hippocampus;Hour;Human;Image;imaging science;Impairment;improved;Intervention;Laboratories;Medial;Mediating;Mediation;Memory;Methods;Modeling;Motivation;National Institute of Drug Abuse;neural;neurobiological mechanism;neuroimaging;neuromechanism;nicotine patch;Nicotine Withdrawal;Participant;Pathway interactions;Pattern;Perfusion;Pharmaceutical Preparations;pharmacologic;pill;Placebos;Play;Policy Maker;pre-clinical;Pre-Clinical Model;preclinical study;preference;Prefrontal Cortex;Procedures;programs;Propranolol;Protocols documentation;Psychological reinforcement;Public Health;Relapse;Research;Research Personnel;response;Rest;Retrieval;Rodent Model;Role;Sampling;Scanning;Scientist;Series;Shapes;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking cue;Stimulus;System;Testing;therapy development;Translational Research;United States;Withdrawal Symptom;Work

PROJECT_TITLE: Beta-Adrenergic Modulation of Drug Cue Reactivity: Neural and Behavioral Mechanisms

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;Neurosciences;Substance Misuse

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat drug abuse and addiction is critically dependent on fundamental understanding of brain networks altered by drugs of abuse and associated signaling pathways. The research described in this proposal will establish a new system to study how cannabinoid signaling impacts intact brains at cellular resolution that culminate in affecting elemental motivated behavior. If successful, it will pave a way to uncover principles of neural circuit development and dynamics, bridge a critical gap between molecules and systems impact associated with drugs of abuse, and shape policy and treatment strategies for drug abuse disorders.

PI_NAMEs: GUO, SU  (contact)

PROJECT_TERMS: Ablation;Address;Affect;Animals;Anti-Anxiety Agents;approach behavior;avoidance behavior;Behavior;Behavioral;Brain;brain cell;Brain region;Calcium;Cannabinoids;Cannabis policy;cell type;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;Complex;computational platform;Corticotropin-Releasing Hormone;Cues;Darkness;Data;Dependence;Development;Diagnosis;Disease;Drug abuse;Drug Addiction;drug of abuse;Elements;endocannabinoid signaling;Endocannabinoids;Enzymes;exogenous cannabinoid;fitness;Food;Foundations;Frequencies;Functional Imaging;Future;Genes;Genetic;Genetic Models;genetic regulatory protein;Glutamates;Head;Human;Hypothalamic structure;Image;imaging platform;Immune;improved;in vivo calcium imaging;interest;Knock-in;knockout animal;Life;Ligands;Light;Lipids;Mammals;model organism;Molecular;Monitor;motivated behavior;Motivation;Motor;Motor Activity;Movement;Mus;neural;neural circuit;Neurons;Neuropeptides;Neurotransmitters;optogenetics;Outcome;Pathway Analysis;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Policies;postsynaptic;preference;Property;Proteins;Public Health;receptor;Receptor Inhibition;Receptor-Interacting Protein;Regulation;Research;Resolution;Resources;response;Rewards;Role;Sensory;sensory stimulus;Shapes;Signal Pathway;Signal Transduction;Slide;social;Specificity;Stimulus;Stress;stressor;System;Tail;Testing;Time;tool;treatment strategy;Vision;Zebrafish

PROJECT_TITLE: Role of endocannabinoid signaling in a preference/aversion circuitry

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Opioids cause many changes in the brain, some of which underlie substance use disorder, but most of which merely reflect exposure to drug, including benefits such as pain relief. Identifying the neural substrates underlying the pathologic side effects of opioid use, and disentangling them from the beneficial effects of opioid drugs in particular, will be critical for intervening in the opioid crisis.

PI_NAMEs: WHISTLER, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;Acute;addiction;Agonist;Analgesics;Animals;Arrestins;Behavior;Behavioral;Biology;Brain;Cells;Characteristics;Clinical;Cognitive;Color;Data;Decision Making;Dependence;Derivation procedure;Diagnosis;Dissociation;Distress;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dose;Down-Regulation;drug abstinence;Drug abuse;Drug Exposure;Drug Modelings;drug withdrawal;Endocytosis;Endorphins;Engineering;Enkephalins;Equilibrium;Essential Drugs;experimental study;Exposure to;Failure;flexibility;G-Protein-Coupled Receptors;GABA Receptor;gamma-Aminobutyric Acid;Genotype;Goals;GTP-Binding Proteins;Human;Impairment;Knock-in Mouse;Lateral;Ligands;Link;Medial;Modeling;Molecular;Monitor;Morphine;Morphine Dependence;mu opioid receptors;Mus;mutant;Naloxone;neural;neuroadaptation;neuromechanism;Neurons;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use;Pain;pain relief;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharmacology;Phenotype;Physical Dependence;Positioning Attribute;Pre-Clinical Model;pre-clinical research;preclinical study;Prefrontal Cortex;prevent;Probability;Property;protein activation;receptor;recruit;Recycling;Regimen;Relapse;Research;response;Rewards;Risk;Role;Self Administration;sensor;side effect;Signal Transduction;Signaling Protein;Study models;Substance Use Disorder;Synapses;Time;Titrations;tool;Ventral Tegmental Area;Weaning;Wild Type Mouse;Withdrawal;Work

PROJECT_TITLE: Signaling balance and opioid dependence

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE A necessary step in the development of improved OUD therapeutics is to understand the architecture and function of endogenous opioid receptor-expressing neural circuits in the brain. Despite extensive research, how these circuits maintain cellular dependence and drive brain-wide maladaptive plasticity across different stages of the addiction cycle is unclear. To address these gaps, we will map the global cell-type identity, shifting connectivity, and ensemble activity of the opioidergic networks throughout various stages of addiction. Our team-driven project will create an integrated, rapidly searchable database to be mined by other researchers to accelerate the pace of OUD research and future development of new OUD treatments.

PI_NAMEs: BASSETT, DANIELLE SMITH;BEIER, KEVIN T;BLENDY, JULIE A;CORDER, GREGORY  (contact)

PROJECT_TERMS: 3-Dimensional;Abstinence;Acceleration;Acute;addiction;Address;Adopted;Amygdaloid structure;Anatomy;Anterior;Architecture;Atlases;Axon;Behavior;behavior measurement;Brain;brain cell;Brain region;cell type;Cells;Characteristics;Chronic;cingulate cortex;Classification;control theory;Coupled;Data Set;Databases;Dependence;Development;Drug usage;endogenous opioids;Epidemic;Equilibrium;Evolution;experimental study;Future;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;Genomics;Graph;Head;high throughput screening;Image;improved;In Situ Hybridization;Incidence;innovation;Label;Lifestyle-related condition;Link;Machine Learning;Maintenance;Maps;mathematical model;Measurement;Methods;Microscope;midbrain central gray substance;Modeling;mu opioid receptors;neural;neural circuit;neural network;neuroadaptation;Neuroanatomy;neuroimaging;Neurons;next generation;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid exposure;Opioid Peptide;Opioid Receptor;opioid use disorder;opioid withdrawal;Output;Pathologic;Pharmaceutical Preparations;Population;Process;Relapse;Research;Research Personnel;Resolution;response;Role;Sampling;searchable database;single nucleus RNA-sequencing;Site;System;Technology;theories;Therapeutic;Time;Tissues;transcriptomics;Ventral Tegmental Area;virus genetics;Visualization;Withdrawal

PROJECT_TITLE: Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanisms


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Research under this grant is aimed to decode a biochemical pathway all cells use under starvation conditions, which is frequently deregulated in cancer. This starvation pathway contains a gene called LKB1 that is mutated in about 20% of lung cancers, for which there are limited effective treatment options available. By studying normal functions of the starvation pathway in growth limitation and metabolic preservation, new therapeutic targets for treating this common form of lung cancer will be identified and experimentally tested.

PI_NAMEs: SHAW, REUBEN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;AMP-activated protein kinase kinase;Autophagocytosis;Biochemical;Biochemical Pathway;Cancer Etiology;Cancer Patient;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;checkpoint therapy;chemotherapy;Clinical;Complex;Consumption;CREB1 gene;CRISPR screen;Data;Disease;Dissection;drug metabolism;effective therapy;Exhibits;fatty acid oxidation;FRAP1 gene;Genes;Genetic;Genetically Engineered Mouse;Glucose;Grant;Growth;Hereditary Malignant Neoplasm;Homeostasis;Human;Immunotherapeutic agent;in vivo;insight;KRP protein;Laboratory Finding;lipid biosynthesis;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;mutant;Mutate;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;Oxygen;Pathway interactions;Patients;Peutz-Jeghers Syndrome;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;preclinical study;preservation;Process;Protein-Serine-Threonine Kinases;Research;Resistance;response;Role;screening;sensor;Serine;Signal Pathway;Starvation;STK11 gene;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;TP53 gene;tumor;tumor growth;tumor metabolism;Tumor Suppressor Proteins;tumorigenic;Work

PROJECT_TITLE: Decoding And Targeting The LKB1-AMPK Signaling Pathway In Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: TULSA

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: CROFF, JULIE MAY (contact);HAYS-GRUDO, JENNIFER ;MORRIS, AMANDA S

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 10/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Childhood glaucoma is an important cause of pediatric blindness worldwide, and particularly in countries such as India where many affected patients may be undiagnosed and treatment options are limited. Genetic testing while potentially useful, currently can only detect molecular diagnoses in 20% of childhood glaucoma cases worldwide. This project will complete large-scale genetic profiling of childhood glaucoma in India to improve genetic testing through discovery of novel genetic causality.

PI_NAMEs: WIGGS, JANEY L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Animal Model;Anterior;aqueous;Biological Assay;blind;Blindness;candidate selection;causal variant;Cells;Child;Childhood;Clinical;clinical care;ClinVar;Collaborations;Complex;Country;Data;Development;Diagnostic;Disease;disease model;Early Intervention;Environment;ethnic diversity;Etiology;European ancestry;Evaluation;Exhibits;exome;Eye Development;Family;Family member;Filipino;follow-up;Frequencies;Future;gene discovery;Gene Expression;Gene Frequency;gene therapy;Genes;Genetic;Genetic Counseling;genetic profiling;genetic risk assessment;Genetic study;genetic testing;genome wide association study;Glaucoma;improved;in silico;In Vitro;in vivo Model;India;Individual;International;Knowledge;Measurement;Medical;Methods;Molecular Diagnosis;novel;Onset of illness;Open-Angle Glaucoma;Operative Surgical Procedures;Pathogenicity;Pathway interactions;Patients;Phenotype;Population;Population Heterogeneity;proband;Process;protein function;rare variant;Research Personnel;Resources;Retina;risk variant;Science;segregation;trait;Variant;web platform;young adult;Zebrafish

PROJECT_TITLE: Genetic profiling of childhood glaucoma in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (02)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The research team will work with providers, staff, management and patients at Cherokee Nation Health Services to culturally adapt and evaluate Counseling for Harm Reduction and Retention in MAT with Cherokee Nation (CHaRRM-CN). In the short-term, this project is positioned to make a strong, individual-level impact by increasing MAT retention, reducing substance-related harm and illicit opioid use, and increasing Native enculturation. This project may have a broader impact on public health by reducing substance-related harm and associated strain on publicly funded services.

PI_NAMEs: COLLINS, SUSAN E;GASSAWAY, ASHLEY ;NELSON, LONNIE A. (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;Address;American Indians;Biochemical;Cherokee Nation;Cognitive Therapy;Communities;community advisory board;comparative efficacy;comparison control;Counseling;Data;Death Rate;Development;efficacy testing;Emergency department visit;Evaluation;evidence base;experience;flexibility;Focus Groups;follow-up;Foundations;Funding;General Population;Goals;Harm Reduction;Health Services;Health system;High Prevalence;illicit opioid;improved;Individual;Interview;Length;Manuals;marginalized population;Medical;medication-assisted treatment;Methods;mortality;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Participant;patient oriented;Patient Self-Report;Patients;Phase;Positioning Attribute;primary outcome;Professional counselor;programs;Provider;Proxy;Public Health;Recommendation;Relative Risks;Research;Research Methodology;Research Personnel;response;retention rate;secondary outcome;self reliance;Services;services as usual;Suboxone;substance use;Substance Use Disorder;substance use treatment;systematic review;treatment as usual;Treatment outcome;treatment program;tribal community;United States Substance Abuse and Mental Health Services Administration;Universities;Washington;Work

PROJECT_TITLE: Counseling for Harm Reduction and Retention in Medication-assisted treatment - Cherokee Nation (CHaRRM-CN)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: PEDIATRICS

PHR: Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BANDOLI, GRETCHEN E. (contact);GAHAGAN, SHEILA

PROJECT_TITLE: 14/24 The Healthy Brain & Child Development National Consortium


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PI_NAMEs: FOX, NATHAN A (contact);HARDEN, BRENDA J;RIGGINS, TRACY L.

PROJECT_TITLE: 16/24 Healthy Brain and Child Development National Consortium


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: UNANDUP, LLC

ORG_STATE: MO

PHR: Arrhythmias are a major cause of US mortality with ventricular fibrillation, ventricular tachycardia, and atrial fibrillation resulting in 430,000 annual deaths. Although catheter ablation is a proven treatment option, as reinforced by the HRS/EHRA/ECAS/APHRS/SOLAECE Expert Consensus Statement, control of ablation catheters can be complex, resulting in imprecise and unreliable heart-wall contact leading to an increased likelihood of injury and arrhythmia recurrence. UNandUP (short for “Unmet Needs and Underserved Populations”) is developing an affordable angiosuite compatible platform which uses low magnetic fields to overcome prior limitations related to electrophysiology catheter navigational accuracy, stability, and applied forces.

PI_NAMEs: CREIGHTON, FRANCIS MILTON (contact);FADDIS, MITCH

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Ablation;Angiography;animal safety;arm;Arrhythmia;Atrial Fibrillation;biomaterial compatibility;Blood coagulation;Cardiac ablation;Catheters;Cause of Death;Cessation of life;Complex;Consensus;Custom;design;digital;efficacy study;Electrophysiology (science);Feasibility Studies;fighting;Friends;Heart;Hospitalization;Hospitals;improved;Injury;Innovation Corps;Learning;magnetic field;Magnetism;Manuals;manufacture;Maps;Medical Care Costs;meetings;meter;Methods;mortality;novel;Pharmacologic Substance;Phase;pre-clinical;Prevalence;prevent;Procedures;prototype;Publishing;Recurrence;robotic system;Robotics;Signal Transduction;System;Technology;Telerobotics;Testing;Tissues;Training;Underserved Population;Ventricular Fibrillation;Ventricular Tachycardia

PROJECT_TITLE: An Improved Robotic Electrophysiology Platform for Arrhythmia Ablation


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative: Young people living with HIV in adolescence through emerging adulthood (ages 16-28 years) have the lowest rates of regular engagement in HIV care and adherence to HIV medications of any age group, with Black and Latinx individuals experiencing the greatest barriers to favorable HIV health outcomes. To provide a detailed understanding of the factors that promote or impede HIV management in this group, we will follow Black and Latinx youth/emerging adults living with HIV, half with optimal HIV health outcomes at enrollment (undetectable HIV viral load) and half without, for 18 months. Participants will engage in structured assessments, in-depth qualitative interviews, real-time ecological momentary assessments in two-week bursts, and biological tests (HIV viral load tests, drug tests), and a Youth Advisory Board comprised of youth living with HIV will help interpret findings in order to inform new policies, health care service practices, and interventions.

PI_NAMEs: GWADZ, MARYA  (contact);WILTON, LEO

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Adherence;Adolescence;Adult;African American;Age;age group;Alcohol consumption;American;antiretroviral therapy;Appointment;Behavior;Behavioral;Biological Markers;Biological Testing;Biometry;Black Populations;Black race;Caring;Cognitive;Continuity of Patient Care;Data;design;Development;Diagnosis;drug testing;Drug usage;Ecological momentary assessment;emerging adult;emerging adulthood;Enrollment;Epidemic;experience;Family Relationship;follow-up;Health;health care service;health care settings;Health Services;Healthcare;high risk;HIV;HIV risk;Homophobia;Hybrids;Individual;innovation;Intervention;Interview;Knowledge;Latinx;Latinx population;Literature;longitudinal design;Longitudinal Studies;longitudinal, prospective study;low socioeconomic status;Medical;Mental Health;Methods;microsystems;Minority;Modeling;Motivation;New York City;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;Policies;policy recommendation;Population;primary outcome;Process;prospective;protective factors;psychologic;Public Health;racism;Recommendation;recruit;Reporting;Research;Resources;Risk;Sampling;secondary outcome;Services;Sexual and Gender Minorities;social;Social Interaction;Social Network;Structure;substance use;substance use treatment;Testing;theories;therapy adherence;Time;United States;United States National Institutes of Health;Viral;Viral Load result;Vulnerable Populations;Youth

PROJECT_TITLE: Advancing knowledge on factors that promote or impede engagement along the HIV care continuum over time: A longitudinal mixed methods study of Black and Latinx youth/emerging adults living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Rehabilitation;Social Determinants of Health;Unintentional Childhood Injury;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Public Health Relevance Statement Adolescents and young adults who survive a non-fatal firearm injury may risk revictimization, the adoption or increase of firearm-related behaviors, poor mental health, and reduced economic mobility. Due to the perpetuating use of firearms in communities and the dearth of knowledge regarding firearm injury survivorship, it is imperative to understand the long-term impact of injury to psychosocial and behavioral health. We will identify risk and protective factors for repeat victimization and increased firearm-related behaviors, and we will explore the characteristics of patient subgroups to facilitate the effectiveness and efficiency of hospital-based violence intervention strategies.

PI_NAMEs: DEMELLO, ANNALYN  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescent and Young Adult;adolescent health;Adoption;Adult;Advisory Committees;Affect;Age;Aggressive behavior;Anxiety;aspirate;Attitude;Behavior;Behavioral;behavioral health;Behavioral Research;Behavioral Symptoms;black men;Caliber;career;career development;Cause of Death;Characteristics;Child Health;Clinical Investigator;Cognition;Communities;Complex;Critical Illness;Data;Development;Economic Factors;Economics;Education;Emotions;Environment;Environmental Health;Environmental Risk Factor;executive function;Exhibits;experience;Firearms;Foundations;Friends;Funding;Future;Goals;Gun injury;gun violence;Gunshot wound;Health;Health Disparities Research;Health Personnel;Healthcare;high risk;Hospitals;implementation study;improved;Impulsivity;Individual;injured;Injury;instrumentation;intervention program;Interview;Knowledge;Learning;Life;Measures;Medical;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;negative affect;novel;Outcome;Outcomes Research;Ownership;Participant;patient oriented research;patient subsets;Patient-Focused Outcomes;Pattern;pediatric trauma;people of color;perpetrators;Post-Traumatic Stress Disorders;professor;prospective;protective effect;protective factors;Psyche structure;psychological distress;psychological symptom;psychosocial;Psychosocial Assessment and Care;Psychosocial Influences;Recording of previous events;recruit;Recurrence;reduce symptoms;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Personnel;research study;response;revictimization;Risk;Risk Behaviors;Risk Factors;Role;Scholarship;School Nursing;Schools;Scientist;screening;Services;skill acquisition;skills;social cognitive theory;social culture;Social support;Statistical Methods;Subgroup;substance use;success;supportive environment;Texas;transition to adulthood;Trauma;trauma centers;Universities;Victimization;Violence;violence exposure;violence prevention;violence victimization;Violent injury;Vision;weapon carrying;Work;wound healing;Writing;young adult;Youth

PROJECT_TITLE: A Longitudinal Mixed Methods Study of Psychosocial and Behavioral Health After Non-Fatal Firearm Injuries Among High-Risk Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (03)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease;Pediatric

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Investigators from Indiana University (IU) propose to continue to take part in the NIDDK funded NASH CRN which has been conducting impact clinical and translational research and clinical trials in adults and children with nonalcoholic fatty liver disease. Since inception, IU has been a highly productive member of the NASH CRN and is committed to its full success during the next funding period.

PI_NAMEs: CHALASANI, NAGA P (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Adult;Alanine Transaminase;Ancillary Study;attenuation;Biological Markers;Biopsy;Child;Childhood;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;Data;Databases;Dimensions;Disease Outcome;Dose;double-blind placebo controlled trial;Enrollment;exome sequencing;Funding;Funding Opportunities;Genetic;genome wide association study;Genomic DNA;Genomics;Goals;Histologic;improved;Indiana;Intervention Studies;Laboratories;Liver;Longitudinal, observational study;member;Mission;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Observational Study;Oral;Outcome;Participant;Pathogenesis;Patients;pediatric non-alcoholic fatty liver disease;Placebos;primary endpoint;Productivity;proteomic signature;Proteomics;Publications;Publishing;Randomized;recruit;Research Personnel;response;Risk Factors;Safety;Sampling;Serum;Severities;Severity of illness;success;System;Therapeutic;transcriptome sequencing;transcriptomics;Translational Research;Universities;Update;Visit;Vitamin E

PROJECT_TITLE: Collaborative Clinical Research in Nonalcoholic Steatohepatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: The NASH CRN's mission is to transform scientific discoveries from laboratory, clinical, and population studies into clinical applications to reduce the incidence and improve clinical outcomes in metabolic dysfunction- associated steatotic liver disease (MASLD). The consortium is dedicated to completing two ongoing studies and utilizing existing data and biosamples for further scientific advancements. The Duke/Lurie Children's Memorial site will focus on accelerated senescence in both adult and pediatric MASLD, translating experimental findings into practical applications for future clinical interventions and preventive measures.

PI_NAMEs: SUZUKI, AYAKO  (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Adolescent;Adult;Affect;Aging;Ancillary Study;Atherosclerosis;Biological;Biological Markers;biomarker development;Child;Childhood;Chronic;chronic liver disease;Cirrhosis;Clinical;clinical application;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;cost effective;Data;Data Collection;data quality;data repository;Data Set;Databases;Dedications;Diagnostic tests;Disease Management;Disease Outcome;Disease Progression;Disparity;Dose;Dyslipidemias;EFRAC;end stage liver disease;Enrollment;Ensure;Exhibits;experience;experimental study;Extrahepatic;follow-up;Foundations;Funding;Future;Genetic;Goals;Heart failure;Hepatocyte;high risk population;Histologic;Hypertension;Immunohistochemistry;improved;improved outcome;Incidence;Individual Differences;Infrastructure;innovation;Innovative Therapy;insight;Insulin Resistance;interdisciplinary approach;Intervention;Investigation;Kidney Diseases;Knowledge;Laboratory Finding;Laboratory Study;Liver;Liver diseases;Liver Fibrosis;liver stiffness;liver transplantation;Metabolic;Metabolic dysfunction;Metformin;Mission;Morbidity - disease rate;mortality;Names;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Organ;Outcome;Participant;participant enrollment;Patients;personalized approach;Population;Population Study;practical application;predicting response;Predisposition;premature;preservation;Preventive measure;Primary carcinoma of the liver cells;Publications;randomized trial;Research;Research Design;Research Personnel;Risk;Risk Assessment;Scientific Advances and Accomplishments;senescence;Serology;Severities;Site;transcriptomics;Translating;Translational Research;trend;Visit;Vitamin E;young adult

PROJECT_TITLE: Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Relevance As the proportion of older adults in the population continues to expand, magnifying the relative impact of their decisions, it is increasingly imperative to better understand changes in decision making across the life span before and throughout all stages of significant cognitive impairment related to Alzheimers Disease and related dementias. Increasing interdisciplinary research combining psychology, neuroscience/neurology, medicine, and economics has tremendous potential for increasing translation of science for real-world impact to better understand and alleviate the burden of Alzheimers Disease and related dementias. The long-term goal of this network is to conduct integrative and multidisciplinary research that contributes directly to interventions aimed at improving health and well being in the daily lives of aging adults.

PI_NAMEs: LIGHTHALL, NICHOLE ;SEAMAN, KENDRA LEIGH (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Awareness;Basic Science;behavior measurement;Behavioral;Biological;Brain imaging;career;career networking;Clinical;Clinical assessments;Clinical Research;Collaborations;Collection;computer science;data access;Data Aggregation;Data Set;data sharing;Decision Making;Development;Discipline;Documentation;Economics;Educational workshop;effective intervention;Ensure;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Health;imaging modality;Impaired cognition;improved;Individual;Institution;Interdisciplinary Study;interest;Intervention;Investments;Leadership;life span;Link;Measures;Medicine;meetings;member;Mentorship;Methodology;Methods;Modeling;multidisciplinary;Neurology;Neurosciences;older adult;Patient Recruitments;Personal Satisfaction;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Psychology;Public Health;Qualitative Research;recruit;Recruitment Activity;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;senior faculty;skill acquisition;social;Sociology;Students;success;Supercomputing;support network;symposium;theories;tool;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Update;Woman;Work

PROJECT_TITLE: Research Network on Decision Neuroscience and Aging


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

PHR: PROJECT NARRATIVE The proposed Equity and Climate Opportunities for Health (ECO-Health) Center at the University of California will generate rigorous scientific evidence about how climate change leads to poor health outcomes within communities that are heavily impacted by structural injustices. The Center will also partner with these communities to use this evidence to co-develop and co-implement climate adaptation interventions that improve health and reduce health inequities. Ultimately, the ECO-Health Center will help generate equitable solutions that build resilience to the health risks of climate change in California communities and beyond.

PI_NAMEs: BENMARHNIA, TARIK ;TEHERANI, ARIANNE ;WEISER, SHERI DAWN (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Affect;Area;Beds;built environment;California;career;career development;Cities;Climate;climate adaptation;climate change;climate impact;climate-related health;Communities;community academic partnership;community engaged research;community engagement;community involvement;Community of Practice;Data;data dashboard;design;Development;Dimensions;Disparity;Disparity population;Elements;environmental justice;Epidemiology;Equity;equity, diversity, and inclusion;experience;extreme heat;Food;Fostering;Foundations;Geography;Goals;Health;Health Benefit;health equity;health inequalities;health knowledge;Health Personnel;Health system;Healthcare;Housing;implementation science;improved;Income;innovation;Intervention;Intervention Studies;Investments;Justice;Life Cycle Stages;life span;Lived experience;Machine Learning;Measures;member;Mental Health;Mentorship;Methods;Mission;Modeling;Modification;Neighborhoods;novel strategies;Outcome;Outcomes Research;physical conditioning;Pilot Projects;Policies;Policy Maker;poor health outcome;Population;Program Development;promote resilience;Reduce health disparities;Reporting;Research;research and development;Research Personnel;Research Project Grants;resilience;Risk;Role;Scientist;Shapes;Smoke;social;social factors;structural determinants;Sustainable Development;Techniques;Testing;Training;Training Support;Translating;Translations;United States;United States National Institutes of Health;Universities;Wildfire;Work


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WEISER, SHERI DAWN (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Advisory Committees;Beds;built environment;California;career development;Climate;climate adaptation;climate change;climate impact;climate-related health;Collaborations;Communication;Communities;community advisory board;community engaged research;community engagement;Community of Practice;community partners;community partnership;Complex;Data;Data Analytics;data harmonization;data hub;data management;data sharing;Decision Making;design;Discipline;Educational workshop;Elements;Ensure;Environment;Epidemiology;Equity;equity, diversity, and inclusion;Food;Fostering;Foundations;Funding;Goals;Grant;hazard;Health;health disparity;Healthcare;Housing;Human;human subject;implementation science;improved;innovation;Institution;Justice;Knowledge;Leadership;Machine Learning;meetings;Methods;Mission;Monitor;next generation;operation;Outcome;Persons;Phase;Pilot Projects;Play;Policies;Policy Maker;poor health outcome;Population;Positioning Attribute;Principal Investigator;Process;programs;Protocols documentation;Reduce health disparities;Regulation;Research;Research Activity;research and development;Research Personnel;Research Project Grants;resilience;Resources;Risk;Role;Science;Scientist;Shapes;social;social factors;Strategic Planning;structural determinants;Structure;Sum;synergism;System;Testing;therapy development;Training;Training Programs;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Equity and Climate Opportunities for Health (ECO-Health) Center: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

PI_NAMEs: THAKUR, NEETA  (contact)

PROJECT_TERMS: Address;Adult;Adverse effects;African American;Air Pollution;Asthma;Birth Certificates;built environment;California;Cardiovascular Diseases;Childhood;Chronic Obstructive Pulmonary Disease;Climate;climate impact;climate policy;climate-related health;Clinical;Collaborations;Color;Communicable Diseases;Communities;community engaged approach;community engaged intervention;community partners;Data;Data Set;demographics;design;Development;Discrimination;Economics;Effectiveness;Emergency Situation;Environmental Hazards;Environmental Health;Epidemiology;Equity;Ethnic Origin;Event;experience;Exposure to;extreme heat;Food;Foundations;Frequencies;Future;Geography;Grant;hazard;Health;health care service utilization;health data;health equity;health inequalities;Healthcare;Heart failure;Heat Waves;Hospitals;Housing;improved;Income;Individual;Inequity;innovation;Intervention;Joints;Justice;Latinx population;Leadership;Life Cycle Stages;Link;Location;Low Birth Weight Infant;low socioeconomic status;Lower Respiratory Tract Infection;Modeling;multidisciplinary;Myocardial Infarction;Not Hispanic or Latino;Outcome;Perinatal;Policies;Politics;Population;Poverty;preference;Pregnancy;pregnancy hypertension;Pregnancy Outcome;Premature Birth;prototype;Pulmonology;Race;Records;Research;Research Project Grants;Resources;respiratory;response;Risk;Risk Factors;Scientist;Series;Smoke;social;social adversity;Social Environment;social factors;socioeconomics;Source;stressor;structural determinants;therapy design;Time;Translating;United States;violence exposure;Wildfire;Work

PROJECT_TITLE: Equity and Climate Opportunities for Health (ECO-Health) Center: Research Project 1


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ARNOLD, EMILY A (contact)

PROJECT_TERMS: Acceleration;Action Research;Adaptation research;Address;Affect;built environment;California;Climate;climate change;climate impact;climate science;climate-related health;Collaborations;Communities;community advisory board;community based participatory research;community engaged approach;community engaged research;community engagement;Community Health;community organizations;Community Participation;community partners;Data;design;Development;empowerment;Ensure;Environment;environmental agent;Environmental Health;Equity;evidence base;experience;Fostering;Foundations;Funding;Government;hazard;Health;health equity;health literacy;Health Professional;Health Sciences;improved;indexing;Individual;innovation;Intervention;Justice;literacy;member;Methods;Mission;Needs Assessment;novel;Personal Satisfaction;personalized approach;Persons;Phase;Policies;Policy Maker;Population;Process;programs;Public Health;Research;Research Activity;research data dissemination;Research Personnel;Research Project Grants;research study;resilience;Resources;Scientific Advances and Accomplishments;Scientist;Shapes;skills;social;social factors;structural determinants;Training;Translating;translational approach;United States National Institutes of Health;Work

PROJECT_TITLE: Equity and Climate Opportunities for Health (ECO-Health) Center: Community Engagement Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy and thus a major public health problem. Seizures may impair arousal to important stimuli, such as CO2, to contribute to SUDEP. Understanding mechanisms for impairment of CO2-arousal in relevant animal models will importantly inform risk stratification and prophylactic strategies against this devastating disease.

PI_NAMEs: BUCHANAN, GORDON F (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Animal Model;Animals;Apnea;Arousal;Biological Markers;Carbon Dioxide;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;chemical reduction;Confusion;Conscious;Data;Death Rate;Detection;Disease;dorsal raphe nucleus;dravet syndrome;Electrocardiogram;Electroencephalography;Epilepsy;epileptic encephalopathies;Etiology;experimental study;Fiber;Genetic;Goals;Impairment;Individual;insight;Intervention;Intractable Epilepsy;Life;Link;Measurable;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nervous System Disorder;Neurons;novel;optogenetics;Outcome;parabrachial nucleus;Pathway interactions;Patients;Phenotype;Photometry;Pilocarpine;prevent;preventive intervention;prophylactic;Public Health;Publishing;Recovery;Regulation;Research;respiratory;response;Risk;Risk Marker;risk stratification;Role;Seizures;Serotonin;Sleep;societal costs;Status Epilepticus;Stimulus;Stroke;Stupor;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;Symptoms;System;Temporal Lobe Epilepsy;Testing;Therapeutic;Wakefulness;Work

PROJECT_TITLE: Serotonergic circuit mechanisms in postictal recovery and arousal

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]