ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative  Biologic drugs and nanomedicines with conjugated polyethylene glycol (PEG) show improved pharmacokinetics. However, the application of PEGylated therapeutics is limited by the presence of anti-PEG antibodies, which not only accelerate the clearance of PEGylated therapeutics and attenuate their efficacies but may also cause severe side effects. We propose to develop zwitterionic PEG as a replacement of PEG in therapeutic delivery for minimized side effects and consistent efficacy.

PI_NAMEs: CHENG, HAO  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acceleration;Adsorption;Affinity;Allergic Reaction;Amines;Antibodies;Antibody Affinity;Antigens;Attention;Attenuated;Azides;B-Cell Antigen Receptor;B-Lymphocytes;Behavior;Binding;Binding Proteins;Biodistribution;Biological;Biological Products;biomacromolecule;Blood;Blood Circulation;carbene;Carboxylic Acids;CD4 Positive T Lymphocytes;Cells;Characteristics;Charge;Chemical Structure;Chemistry;Circulation;Complement Activation;Cosmetics;COVID-19;Data;density;design;Diffusion;Drug Kinetics;Entropy;Ethers;Ethylenes;Excision;experimental study;Extracellular Matrix;flexibility;Foreign Bodies;Generations;Healthcare;High Prevalence;Hydration status;hydrophilicity;Hypersensitivity;immune clearance;Immune response;immunogenic;immunogenicity;Immunotherapeutic agent;improved;In Vitro;in vivo;Kinetics;Length;Life;lipid nanoparticle;Measures;Mediating;Medical Device;Modeling;Molecular Conformation;Mucous body substance;Mus;Mutate;nanomedicine;nanoparticle;novel;Nucleotides;Peptides;Pharmaceutical Preparations;Physics;Plasma Proteins;Polyethylene Glycols;Polymers;Population;prevent;Process;Property;Proteins;Publications;Radial;rational design;Reaction;Receptor Signaling;Renal clearance function;Reporting;Research;Research Personnel;response;RNA vaccine;side effect;Structure;T-Lymphocyte;Therapeutic;therapeutic protein;Thermodynamics;Toll-like receptors;Treatment Efficacy;Urate Oxidase;Vertebral column;Water

PROJECT_TITLE: Zwitterionic polyethylene glycol for therapeutic delivery

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Vaccines against influenza virus infection induce protetive antibody responses. However, these vaccine-induced immune responses are often not as durable as seen after infection. In the proposal we are investigating factors that might be responsible for the better immunity induced to infection than to vaccination with influenza virus. By identifying these factors we hope to learn how we can generate vaccines that trigger longer-lasting and better immune protection.

PI_NAMEs: BAUMGARTH, NICOLE  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: adaptive immunity;Adjuvant;Adoptive Transfer;Affect;Affinity;Agonist;Antibodies;Antibody Response;Antigens;arm;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Cells;Complex;Contracts;cytokine;Development;draining lymph node;Early identification;experience;Flow Cytometry;Genetic Transcription;Homo;Humoral Immunities;IL2 gene;IL2RA gene;Immune;Immune signaling;Immunity;Immunization;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Infection;Influenza;Influenza Hemagglutinin;influenza infection;influenza virus vaccine;influenzavirus;Innate Immune Response;Interferons;Knowledge;Learning;Lung;Lymph;lymph nodes;Mediating;Memory;Memory B-Lymphocyte;mouse model;Mus;novel;Phenotype;Plasma Cells;Plasmablast;Population;Proliferating;Regulation;Respiratory System;Respiratory Tract Infections;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Stimulus;Structure of germinal center of lymph node;Testing;Time;Tissues;TLR3 gene;TLR7 gene;Transcript;Up-Regulation;Vaccination;Vaccine Design;vaccine immunogenicity;Vaccines;Viral;Virus;Work

PROJECT_TITLE: Extrafollicular B cell response regulation during influenza infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Moyamoya disease (MMD), characterized by bilateral progressive stenosis and occlusion of the internal carotid arteries, is a common cause of stroke in children, and we propose that lack of differentiation of smooth muscle cells (SMCs) is the causative pathologic mechanism. A pathogenic prevents The SMC prospective complications specific amino acid change in the smooth muscle α-actin ( SMA protein causes MMD and nuclear localization of SMA, l eading to an incompletely differentiated SMC phenotype. proposed studies will address the mechanisms linking loss of nuclear SMA with incomplete differentiation, which will provide new insights into SMC development, and will test treatment strategies that can restore SMC phenotype and potentially prevent clinical in young patients with these SMA variants. )

PI_NAMEs: KWARTLER, CALLIE S (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Actins;Affect;alpha Actin;Amino Acids;Aorta;Aortic Diseases;Arginine;beta Actin;Bilateral;Binding;Bioinformatics;Brain;Brain region;Cell Differentiation process;Cell division;cell fate specification;Cell Line;cell motility;Cell Nucleus;Cell Proliferation;Cell Separation;Cell Shape;Cells;cerebrovascular;Cerebrovascular Disorders;Child;Childhood;Childhood stroke;Cholesterol;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;CRISPR/Cas technology;Data;Data Set;Defect;Development;Dimensions;Disease;disease-causing mutation;Distal;Embryo;Epigenetic Process;EZH2 gene;FDA approved;Foam Cells;Future;Genes;Genetic;Genetic Recombination;genetic risk factor;Genetic Transcription;genetic variant;genome editing;Goals;Heritability;Heterozygote;histone modification;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;inhibitor;Injury;insight;Internal carotid artery structure;Knock-in;Knock-in Mouse;Left;Lesion;Ligation;Link;loss of function;Maintenance;migration;Modeling;Molecular;mosaic;Mosaicism;mouse model;Moyamoya Disease;Mus;Muscle Contraction;mutant;Mutation;Neuroectodermal Cell;novel;Nuclear;Onset of illness;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Phenotype;Polycomb;postnatal;prevent;Proliferating;promoter;prospective;Proteins;Repressor Proteins;Research;Role;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Stains;stem cells;Stenosis;Stroke;Testing;Therapeutic;Thoracic aorta;Time;time use;transcriptomics;treatment strategy;Up-Regulation;Variant;Vascular Diseases;Work

PROJECT_TITLE: A novel nuclear role for smooth muscle alpha-actin

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Health inequities in older adults along racial and sociodemographic lines are pervasive, overall and among older adults living with Alzheimer’s Disease (AD) and AD-related dementias (ADRD). Accountable care organizations (ACOs), in which groups of clinicians assume responsibility for quality and costs of care for patient populations on an annual basis, are one promising mechanism by which to improve equity and outcomes. In this project, we will use quantitative and qualitative methods to study the ACO Realizing Equity, Access, and Community Health (ACO REACH) program, which is an ACO program specifically aimed at reducing health inequities among Medicare beneficiaries, including people from minoritized racial and ethnic groups and those living in poverty.

PI_NAMEs: JOYNT MADDOX, KAREN ELLEN (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: accountable care organization;Address;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;beneficiary;Black Populations;Black race;care coordination;care costs;care delivery;care fragmentation;care outcomes;Caring;Characteristics;Chronic Disease;Clinical;Community Health;Complex;Data Collection;Decision Making;Dementia;dementia care;deprivation;design;Diagnosis;Disease;Elements;Enrollment;Equity;Ethnic Population;flexibility;Future;Goals;Group Practice;health equity;health inequalities;high risk;Hispanic;Hispanic Populations;Home;Hospitalization;implementation framework;implementation science;implementation strategy;Improve Access;improved;improved outcome;Income;Individual;Inequity;informant;innovation;Interview;lens;Medical;Medicare;meetings;Minority Groups;Modeling;Neighborhoods;novel;nursing skill;older adult;Outcome;Participant;Patient Care;patient population;Patients;payment;Persons;Population;Poverty;primary outcome;programs;Qualitative Methods;Quality of Care;Race;racial minority population;racial population;Risk Adjustment;Risk Factors;safety net;Savings;Series;Service delivery model;social;sociodemographics;Structure;success;Time;Translating;Underserved Population;United States;Update;Work

PROJECT_TITLE: The Impact of the Accountable Care Organization Realizing Equity, Access, and Community Health (ACO REACH) Program on Outcomes and Equity for Patients with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Idiopathic inflammatory myopathies (IIM) such as dermatomyositis are a group of inflammatory disorders characterized by muscle weakness and associated with significant morbidity and mortality with limited treatment options that focus largely on the use of broad-spectrum immunosuppressive drugs with significant complications. Myositis and other IIM represent a truly unmet medical need as there is currently no cure for any IIM. Our research project will test if a new mechanism of muscle cell damage contributes to the progression of myositis and generate proof-of-principle data that increasing the membrane repair capacity of muscle cells may be an effective therapy for the treatment of myositis that does not involve immunosuppression.

PI_NAMEs: JARJOUR, WAEL N (contact);WEISLEDER, NOAH

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;Adoptive Transfer;Adrenal Cortex Hormones;Age Months;Animal Model;Antibodies;Antigen Presentation;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;B-Lymphocytes;cell injury;Cell membrane;Cell Physiology;Cells;Cessation of life;Clinical;clinical investigation;cohort;Data;Defect;Dermatomyositis;Development;Disease;DYSF gene;effective therapy;efficacy testing;Exhibits;Exposure to;extracellular;Extracellular Space;FOXP3 gene;Goals;Histologic;Histology;Idiopathic Inflammatory Myopathies;Immunization;Immunosuppression;Immunosuppressive Agents;Impairment;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;innovation;insight;Intravenous Immunoglobulins;Journals;Knockout Mice;Link;link protein;lymph nodes;Mechanical Stress;Medical;Membrane;Methotrexate;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle Proteins;Muscle Weakness;mycophenolate mofetil;Myopathy;Myositis;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Physiological;Poloxamers;Polymers;Process;Production;Proteins;Publishing;Rag1 Mouse;Recombinant Proteins;Regulatory T-Lymphocyte;repaired;Research Project Grants;response;Role;Sampling;Serum;Site;Skeletal Muscle;synaptotagmin VII;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic evaluation;trafficking;Transgenic Organisms;Treatment-related toxicity;Vesicle;Work

PROJECT_TITLE: Autoantibodies to membrane repair proteins in myositis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Sepsis caused by the bacteria Streptococcus pneumoniae (pneumococcus) causes significant mortality, and carries a case fatality rate of > 20%. Sepsis is defined as life-threatening organ dysfunction due to a dysfunctional host immune response to an infection. We have new data showing that when cells respond to pneumococcal infection with more rapid changes in cell metabolism because of a different genetic variant, mice are more likely to die of sepsis. The proposal investigates the inflammatory, physiological and metabolic consequences of expression of this variant in mice infected with pneumococcus, and initiates a search for therapies that prevent septic death.

PI_NAMEs: MORLEY, SHARON CELESTE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acceleration;Affect;Anabolism;Anti-Inflammatory Agents;antimicrobial;Aspartate;Automobile Driving;Bacteremia;Bacteria;Biological Response Modifiers;Blood;Blood Coagulation Disorders;Blood Pressure;Blood Vessels;Bone Marrow;candidate identification;Cardiac;Case Fatality Rates;Cell Physiology;Cells;Cellular Immunology;Cellular Metabolic Process;Cessation of life;Chimera organism;Citric Acid Cycle;Clinical;Communicable Diseases;cytokine;Data;Disease;donor stem cell;Down-Regulation;Echocardiography;Electron Transport;Enzymes;Evaluation;Exhibits;Extravasation;Functional disorder;Gene Expression Profile;Generations;Genes;genetic variant;Genotype;Genus Hippocampus;Glycolysis;Goals;Health;Heart;heart metabolism;Hematopoietic;Hematopoietic stem cells;Histology;Human;Immune;Immune response;Immunity;Immunologic Factors;immunomodulatory therapies;Immunosuppression;improved;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Inflammatory Response;Inner mitochondrial membrane;innovation;Kidney;Knowledge;Lead;Life;lipid biosynthesis;Lipids;Liver;Lung;lung histology;Lung infections;Metabolic;metabolic profile;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardium;novel;novel therapeutics;Organ;Outcome;Oxidants;Oxidative Phosphorylation;pathogen;Pathway interactions;Physicians;Physiological;Physiology;Pneumococcal Infections;Population;Predisposition;prevent;PTPRC gene;Qualifying;reconstitution;Research;response;Risk;Scientist;Sepsis;septic;Serum;Serum Markers;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Specific qualifier value;Streptococcus pneumoniae;Succinates;Supplementation;Supportive care;System;Technology;Testing;therapeutic target;Thrombin;Tissues;Transcriptional Regulation;transcriptomics;Troponin;Tyrosine;Ubiquinone;ubiquinone 6;Ubiquinone Biosynthesis Pathway;Vaccines;Variant;Wild Type Mouse

PROJECT_TITLE: Novel coenzyme Q6 variant reveals non-immune determinants of survival during pneumococcal sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Pulmonary Fibrosis

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE Conventional ultrasound does not allow the quantitative assessment of the severity of pulmonary edema and fibrosis. We propose to develop quantitative ultrasound methods to assess the severity of pulmonary edema in patients with heart failure, and to monitor response to diuretic treatment. We will also investigate whether these methods can be used for the diagnostic and assessment of severity of pulmonary fibrosis.

PI_NAMEs: MAMOU, JONATHAN ;MULLER, MARIE  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Affect;Air;Alveolar;Alveolar wall;Alveolus;American;Appearance;Area;attenuation;Biological Markers;Blood;Body Weight;cardiology service;Chest wall structure;Chronic;Clinical Research;clinical translation;Compensation;Coughing;Data;data acquisition;density;Development;Diagnosis;Diagnostic;Disease Progression;Diuretics;Dryness;Edema;experimental study;Family suidae;Fibrosis;fibrotic lung;Frequencies;Goals;healthy volunteer;Heart failure;High Resolution Computed Tomography;Histology;Hospitals;Human;Human Volunteers;idiopathic pulmonary fibrosis;Image;imaging modality;in vivo;Intake;Interobserver Variability;Interstitial Lung Diseases;ionization;Ionizing radiation;Liquid substance;Lung;Lung Diseases;Measurement;Measures;Medical Research Council Dyspnea Scale;Methods;Monitor;Morphologic artifacts;North Carolina;novel;Output;Patient Monitoring;Patients;Periodicals;Persons;Pilot Projects;point of care;portability;Probability;Public Health;Pulmonary Edema;Pulmonary Fibrosis;Pulmonary function tests;quantitative ultrasound;radiologist;response;Rodent Model;Sensitivity and Specificity;Severities;Shortness of Breath;simulation;Structure;Structure of parenchyma of lung;Study models;Surface;System;Thick;Thoracic Radiography;Time;Tissues;Ultrasonic wave;Ultrasonography;ultrasound;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative Ultrasound for Interstitial Lung Diseases

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BRONX

ORG_DEPT: PSYCHIATRY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This study addresses the critical knowledge gap in understanding how peptidergic neuromodulation dynamically adapts cerebellar processing to physiological state and behavioral context. We investigate the fundamental cellular and circuit mechanisms by which the neuropeptide oxytocin regulates information processing in the cerebellar cortex, establishing the cerebellum as an oxytocin-sensitive brain region that may link cognitive-affective and motor components of complex behavior. These findings have implications for neurodevelopmental, psychiatric, and neurological disorders characterized by impairments in both social communication and motor domains.

PI_NAMEs: RUDOLPH, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Ablation;Action Potentials;Acute;Address;Affect;Affective;affiliative behavior;Anatomy;Area;awake;Axon;Behavior;Behavior Control;Behavior Disorders;Behavioral;Brain;Brain region;Calcium;cell type;Cells;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Cerebrospinal Fluid;Chemistry;Closure by clamp;Cognitive;comorbidity;Complex;Coupled;Coupling;Cytoplasmic Granules;Data;Degenerative Disorder;Electrophysiology (science);Elements;Exclusion;Failure;Fluorescent in Situ Hybridization;Functional Imaging;Future;Gap Junctions;Gene Expression;Gene Expression Profiling;Genetic;Goals;Golgi Apparatus;granule cell;Hormones;Human;Image;Impairment;In Vitro;in vivo;Individual;information processing;insight;Interneurons;Knowledge;Link;Logic;Maps;Measures;Mediating;Mental disorders;Minor;Molecular;mossy fiber;Motor;Motor Activity;mouse genetics;multimodality;multisensory;Mus;Nervous System Disorder;neural network;Neurodevelopmental Disorder;Neuromodulator;neuronal excitability;Neurons;Neuropeptide Receptor;Neuropeptides;neuroregulation;Output;Oxytocin;Oxytocin Receptor;patch clamp;Peptides;pharmacologic;Pharmacology;Physiological;Play;Population;Process;Property;Purkinje Cells;receptor;receptor binding;receptor expression;response;Rodent;Role;Sensory;sensory input;Shapes;Signal Transduction;Slice;Social Behavior;social communication;Synapses;Synaptic Transmission;System;Testing;Tissues;two-photon

PROJECT_TITLE: Peptidergic Neuromodulation of the Cerebellum

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating syndrome of unknown etiology. This proposal seeks to determine if there are distinct cells in the spinal cord that contribute to bladder sensation and overactive bladder in IC/BPS. These studies will improve our current understanding of how spinal cord processes bladder sensations and possibly launch new avenues for drug discovery for relieving IC/BPS.

PI_NAMEs: SAMINENI, VIJAY K (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Absence of pain sensation;Affect;allodynia;anatomical tracing;Anatomy;Animals;Anterolateral;Attenuated;Behavioral;Bladder;bladder pain;Brain;Brain region;Cardiovascular system;Cell Nucleus;cell type;Cells;Central cord canal structure;central sensitization;Chronic;Classification;Clinical;Clinical Research;Cordotomy;Cutaneous;Cystitis;Development;Dorsal;dorsal column;dorsal horn;drug discovery;druggable target;Electrophysiology (science);Esthesia;Etiology;Exhibits;experimental study;Fiber;Fluorescent in Situ Hybridization;Functional disorder;Genetic;Goals;Gray Commissure;Human;improved;In Situ Hybridization;Increased frequency of micturition;insight;Interstitial Cystitis;Knowledge;Label;Lesion;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Micturition Reflex;midbrain central gray substance;Modality;Molecular;molecular marker;Mus;Neurons;neurotransmission;Neurotransmitters;Nociception;novel therapeutic intervention;optogenetics;Organ;Overactive Bladder;Pain;pain relief;parabrachial nucleus;Pathologic;Pathway interactions;Patients;Pelvic Pain;Pelvis;Pharmacological Treatment;Play;Population;Posterior Horn Cells;pressure;Primates;Process;receptor;response;Rodent;Role;Seminal;Sensory;Series;side effect;Signal Transduction;single nucleus RNA-sequencing;somatosensory;Spinal;Spinal Cord;Spinal cord posterior horn;spinal pathway;Stream;Structure;Symptoms;Syndrome;System;Testing;transcriptomics;transmission process;treatment strategy;United States;Urination;Visceral;Visceral pain;Woman;Work

PROJECT_TITLE: Elucidating Roles of Distinct Spinal Cord Cell types in Mediating Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

PHR: PROJECT NARRATIVE Precision Medicine has now been firmly incorporated into the routine standard-of-care in many medical specialties, in stark contrast with Psychiatry where quantitative predictors that guide clinical decision-making remain extremely limited. Our proposed studies aim to advance the goals of Precision Psychiatry by using artificial intelligence to build clinical outcome predictors of psychosis through integration of electronic health records, dimensional phenotyping, and genetic information, in addition to exploring the psychosocial impact on patients and clinicians. Our long-term goal is to advance the tools available for personalized approaches to diagnosis, treatment, and prognosis in mental health.

PI_NAMEs: ZODY, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Antipsychotic Agents;Artificial Intelligence;Attitude;biobank;cardiometabolism;Classification;CLIA certified;Clinical;clinical decision-making;clinical implementation;clinical practice;clinical predictive model;clinical predictors;clinical subtypes;Code;Cognition;cohort;comorbidity;Computer Analysis;Consensus;Consent;Copy Number Polymorphism;Data;Data Analytics;Data Collection;Database Management Systems;Databases;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Dimensions;Disease;DNA;Electronic Health Record;emotional reaction;Ethics;experience;Future;Genetic;genetic analysis;Genetic Counseling;genetic information;genome sequencing;genomic data;Goals;Impairment;improved;Individual;individual patient;individualized medicine;Institutionalization;Insurance;Interview;Knowledge;Life;long term hospitalization;Machine Learning;Medicaid;Medical;medical specialties;Medicine;meetings;Mental Health;Methods;model building;Modeling;Monitor;mortality;multidisciplinary;Nature;New York;novel;Outcome;outcome prediction;Pathogenicity;Patient Recruitments;patient subsets;Patients;Perception;personalized approach;Persons;Pharmacological Treatment;Phenotype;phenotypic data;Population;Population Database;precision medicine;predict clinical outcome;predictive modeling;preventive intervention;Prognosis;prognostic;prospective;Psychiatry;Psychoses;psychosocial;Public Health;rare variant;Recovery;recruit;Refractory;Research;Resistance;Resource Allocation;Risk;Sampling;Schizophrenia;Services;severe mental illness;Severity of illness;side effect;Site;social health determinants;standard of care;Study models;Surveys;System;tool;treatment optimization;treatment planning;treatment response;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: 2/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (60)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE CAR-T cell therapy has revolutionized the treatment of lymphoma, but its unprecedented efficacy is often limited by acute ICANS (Immune Effector Cell Associated Neurotoxicity Syndrome), which may increase the risk for neurocognitive dysfunction; however, the chronic neurologic impact of CAR-T cell therapy has not been studied systematically. Our proposal will describe the molecular, neurocognitive and neuroimaging features of acute and chronic neurotoxicity through retrospective and prospective cohorts of lymphoma patients treated with CAR-T cells, with the overarching goal of providing a comprehensive characterization of neurotoxicity and improving current trial and therapeutic design in this vulnerable set of patients.

PI_NAMEs: SANTOMASSO, BIANCA DENISE (contact)

PROGRAM_OFFICER_NAME: EPSTEIN, MONICA

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Adult;Agonist;anakinra;Anisotropy;antagonist;anti-cancer research;Aphasia;Attention;biobank;Bioinformatics;Biometry;Blood;Brain;CAR T cell therapy;Cells;Cerebrospinal Fluid;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinical;clinical decision-making;Clinical Management;Coma;cytokine;Data;design;Development;Disease;Encephalopathies;Enzymes;executive function;experience;Functional disorder;Glial Fibrillary Acidic Protein;Goals;gray matter;Hematologic Neoplasms;Immune;immune effector cell-associated neurotoxicity syndrome;Immunology;Immunosuppression;improved;Inflammatory;Infusion procedures;Injury;innovation;insight;Interleukin-1;Intervention;Kynurenine;Light;Link;Lymphoma;Memory;Molecular;multidisciplinary;Myeloid Cell Activation;Myeloid Cells;N-Methyl-D-Aspartate Receptors;Neurocognitive;neurocognitive test;neurofilament;neuroimaging;Neurologic;Neurologic Symptoms;Neurology;Neurons;Neuropsychology;neurotoxic;neurotoxicity;novel;Outcome;overexpression;Pathogenesis;Pathway interactions;patient subsets;Patients;Performance;peripheral blood;Phase II Clinical Trials;Phenotype;Pilot Projects;Positioning Attribute;potential biomarker;prevent;Production;prospective;Prospective cohort;Proteins;psychiatric symptom;Quinolinic Acid;Reporting;Research;response;Rest;Retrospective cohort;Risk;Sampling;Seizures;Serum;Structure;systemic inflammatory response;Therapeutic;Toxic effect;Transcript;transcriptome;Treatment Efficacy;Tryptophan 2,3 Dioxygenase;verbal;white matter

PROJECT_TITLE: Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Comparative Effectiveness Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Nanotechnology;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Most children with cancer globally are diagnosed in low and middle-income countries, where there is limited access to tools for pathologic diagnosis and, by extension, a high probability a child will receive the wrong treatment for their disease and needlessly die. Recent advancements in nanopore-based platforms for RNA sequencing provide a transformative low-cost, flexible and scalable approach, with potential for broad applicability to the diagnosis of most pediatric cancers. We propose to developa cost-effective nanopore RNA sequencing-based platform to characterize diverse pediatric tumors and prospectively validate its effectiveness in a realistic LMIC setting; in a step toward ultimately curing more children with cancer globally.

PI_NAMEs: AIJAZ, JAVERIA ;ALEXANDER, THOMAS BLICK;WANG, JEREMY R (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: accurate diagnosis;Acute leukemia;acute leukemia cell;Air;cancer classification;cancer diagnosis;Cancer Diagnostics;Capital;Cell Lineage;Cells;Cephalic;Cessation of life;Child;Childhood;Childhood Cancer Treatment;Childhood Extracranial Solid Tumor;Childhood Leukemia;Childhood Lymphoma;Childhood Solid Neoplasm;Classification;clinically actionable;clinically relevant;cloud based;Cloud Computing;computational pipelines;Computer software;cost;cost effective;Country;Cytogenetics;Data;Diagnosis;Diagnostic;diagnostic platform;diagnostic strategy;diagnostic technologies;Disease;Disparity;Effectiveness;flexibility;Flow Cytometry;Formalin;Gene Expression Profiling;Genomics;global health;Healthcare;Histologic;hospital care;improved;Income;Infrastructure;Investments;low and middle-income countries;Lymphoma;machine learning classification;Maintenance;Malawi;Malignant Childhood Neoplasm;Malignant Neoplasms;Messenger RNA;Methodology;Methods;Modeling;Modernization;Molecular;molecular diagnostics;Mononuclear;mRNA sequencing;nanopore;North Carolina;opportunity cost;Pakistan;Paraffin Embedding;Pathologic;Pathology;pediatric acute leukemia;Pediatric Neoplasm;point of care;Prevention;Probability;prospective;Protocols documentation;Publishing;Quality Control;Reporting;Research;Research Personnel;Saint Jude Children's Research Hospital;Sampling;sequencing platform;Solid Neoplasm;Specimen;standard of care;Supportive care;Technology;technology platform;Time;tool;transcriptome sequencing;treatment center;United States;Universities;Update;Validation;virtual;Work

PROJECT_TITLE: Characterization of Diverse Pediatric Cancers in LMIC Using Low-Cost Nanopore Sequencing

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The disruption of gene expression through Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2), which consists of a group of proteins that serve an essential role in chromatin regulation, is a common occurrence in various human malignancies, including cancer. While PRC2 has been the primary focus of pharmaceutical research, our objective is to identify small molecules that can specifically inhibit PRC1. Validated and selective inhibitors of PRC1 could provide unique insights beyond conventional genetic techniques and offer new options for therapeutic development, potentially addressing the existing challenges associated with PRC2 inhibition in cancer treatment.

PI_NAMEs: BELL, OLIVER  (contact);PASS, IAN

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Address;analog;B-Cell Lymphomas;Biological Assay;Biology;cancer cell;cancer therapy;Catalogs;Cell Proliferation;Cell Survival;Cells;Cellular Assay;Chemicals;Chromatin;Chromatin Remodeling Factor;Collaborations;Complex;derepression;Dose;drug development;Drug Targeting;Epigenetic Process;Expression Profiling;EZH2 gene;FDA approved;Flow Cytometry;Future;Gene Expression;gene repression;Gene Silencing;Genes;Genetic;Genetic Techniques;Genetic Transcription;Genomics;Histone H3;histone modification;Human;Hyperactivity;inhibitor;innovation;insight;Intervention;Libraries;Luminescent Measurements;Lymphoma;Lysine;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;Molecular Biology;mutant;Mutation;new therapeutic target;novel;novel strategies;overexpression;Pathway interactions;Pharmacologic Substance;Poison;Polycomb;Powder dose form;PRC1 Protein;pre-clinical assessment;programs;Proteins;Publishing;recruit;Regulation;Reporter;Reporter Genes;Repression;Research;response;Risk;Role;Sarcoma;scaffold;Second Primary Cancers;Signal Transduction;small molecule;small molecule inhibitor;SMARCB1 gene;Structure-Activity Relationship;System;Tetanus Helper Peptide;Therapeutic;therapeutic development;Tissues;tool;translational study;tumor;Validation

PROJECT_TITLE: Discovery of small molecules targeting Polycomb repressive complexes 1 and 2

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE As an important oral pathogen, the oral bacterium Treponema denticola is not only associated with oral infections (e.g., periodontitis, necrotic root canals and endodontic infections) but also implicated in several systemic illnesses such as Alzheimer’s disease and oral squamous cell carcinoma. However, little is known about its virulence determinants that are associated with those diseases. Therefore, identification of virulence factors and understanding their roles in the pathogenicity of T. denticola will ultimately lead to a new modality to prevent and treat periodontitis and probably other diseases as well.

PI_NAMEs: LI, CHUNHAO CHRIS (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abnormal Cell;Abscess;Acute;Address;Adherence;alveolar bone;Alveolar Bone Loss;Alzheimer's Disease;Anabolism;Animal Model;Apical;Bacteria;Binding Proteins;Biochemistry;Bioinformatics;Bone Resorption;Cells;Cellular Morphology;Cellular Structures;Chemical Structure;Chemicals;Complex;cytokine;design;Disease;Endodontics;Endotoxins;Esters;Fatty Acids;Functional disorder;Gene Cluster;Genes;Genetic;Genetic Determinism;Genetic Transcription;Glycerol;Glycolipids;glycosyltransferase;Immune response;Immunology;Impairment;In Vitro;in vivo;Infection;Inflammatory;insight;interdisciplinary approach;Interleukin-12;Interleukin-6;Invaded;Knowledge;Lipids;lipooligosaccharide;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;lipoteichoic acid;Macrophage;Mass Fragmentography;member;Membrane;Microbial Biofilms;Modality;Molecular;Molecular Sieve Chromatography;monocyte;Monosaccharides;Motility;mouth squamous cell carcinoma;Mus;mutant;Necrosis;novel;Oral;oral bacteria;oral infection;oral pathogen;osteoclastogenesis;pathobiont;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Periodontitis;periodontopathogen;Phenols;Play;Polysaccharides;prevent;Probability;Production;Protein Biosynthesis;Proteins;Pulp Canals;Regulation;Reporting;response;Role;Second Messenger Systems;skin lesion;structural biology;Structure;sulfoglycolipids;sulfotransferase;Systemic disease;Techniques;Testing;trait;Treponema denticola;Virulence;Virulence Factors;Water

PROJECT_TITLE: Decoding the glycome of oral Treponema denticola

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Immunotherapy;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Public Health Statement The genetic logic circuit is invaluable in basic research and has the potential to transform diagnostics, cell fate reprogramming, tissue engineering, and cell therapy, but their sensitivity and specificity need to be improved before they can be widely adopted. We proposed to develop tools that can enhance the sensitivity and specificity of signal detection in immune cells. Success from this work will greatly enhance our ability to design novel living devices for therapeutic and diagnostic applications.

PI_NAMEs: WONG, WILSON  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Adopted;Antigens;Appearance;Arithmetic;Basic Science;Biological Markers;Biotechnology;Blood;Blood Circulation;Blood Tests;cancer cell;Cancer Diagnostics;cancer therapy;Cell Line;Cell Therapy;Cells;cellular engineering;Characteristics;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;clinically relevant;Collection;combinatorial;cost effective;cytokine;design;Detection;detection method;Devices;Diagnostic;Diagnostic Equipment;digital;DNA;DNA Footprint;Early Diagnosis;Engineering;Enhancers;Ensure;Excision;Exhibits;extracellular;Female Genital Diseases;Foundations;Gene Expression;Genes;Genetic;Genetic Engineering;Heterodimerization;Image;Immune;Immune Targeting;improved;In Vitro;in vivo;in-vivo diagnostics;Inflammation;Leucine Zippers;Libraries;Location;Logic;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Cell;manufacture;Memory;Modeling;Monitor;MSLN gene;Mus;neoplastic cell;Noise;novel;Output;ovarian neoplasm;Pathologic;Performance;Positron-Emission Tomography;prevent;Process;Production;Public Health;Publishing;receptor;recombinase;Reporter;response;ROR1 gene;Science;Screening for Ovarian Cancer;self assembly;Sensitivity and Specificity;sensor;Signal Transduction;Site;Site-Directed Mutagenesis;small hairpin RNA;small molecule;Solid Neoplasm;Specificity;success;Surface Antigens;System;Technology;Therapeutic;Time;Tissue Engineering;tool;trafficking;Transcription Initiation;tumor;Tumor Antigens;tumor diagnostic;tumor immunology;ward;Work;Xenograft procedure

PROJECT_TITLE: Engineering recombinase circuits for cellular diagnostic devices

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Clostridioides difficile (Cd) infections (CDIs) constitute a significant public health challenge, annually affecting ~500,000 individuals in the U.S. alone. The etiologies of CDIs are complex and depend on pathogen variations, gut microbiome (GM) composition, and environmental exposures (i.e., antibiotics); however, how these environmental and microbial-host factors interact to affect disease progression remains unknown. To address this gap in knowledge, we propose to leverage our extensive collection of cultured Cd isolates and patient stool samples from Cd carriers and CDI patients to i) identify genomic determinants of Cd pathogenesis, ii) establish GM signatures of Cd colonization and CDI onset, and iii) investigate the role of clinically-relevant Cd genetic variation in disease development utilizing defined GM-humanized gnotobiotic animal models.

PI_NAMEs: DANTAS, GAUTAM  (contact);DUBBERKE, ERIK R

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Affect;Animal Model;Antibiotics;antimicrobial;Architecture;Atlases;Bacterial Model;bacteriome;Bacteriophages;biobank;Biological;Biological Markers;Clinic;Clinical;clinically relevant;Clostridium difficile;cohort;Collection;commensal bacteria;Communicable Diseases;Community Networks;comparative;Complex;computerized tools;cost;deep sequencing;design;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Disease Progression;Elements;Environmental Exposure;Etiology;Feces;follower of religion Jewish;genetic element;Genetic Transcription;Genetic Variation;Genome;genome analysis;genome sequencing;Genomics;Gnotobiotic;Goals;gut microbiome;gut microbiota;healthcare-associated infections;Hospitals;host microbiome;Human;improved;in vivo;Individual;Infection;infection risk;innovation;innovative technologies;Integration Host Factors;Investigation;Knowledge;Lead;Mediating;Metadata;Metagenomics;metatranscriptomics;microbial community;microbial host;microbiome;microbiome alteration;microbiome composition;microbiome signature;Modeling;Morbidity - disease rate;mortality;Motivation;mouse model;novel;novel diagnostics;Outcome;pan-genome;pathobiont;pathogen;Pathogenesis;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Persons;Phylogenetic Analysis;pre-clinical;Precision therapeutics;predictive modeling;Predisposition;prevent;previous epidemic;Pseudomembranous Colitis;Public Health;Recurrence;Reproducibility;Research;resident commensals;Resolution;Risk Assessment;Role;Severity of illness;Specimen;Statistical Models;stem;stool sample;Taxonomy;Technology;Testing;Therapeutic;tool;Toxin;trait;transmission process;Variant;virome;Virulence;Virulent;whole genome;Work

PROJECT_TITLE: High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Bipolar Disorder;Brain Disorders;Clinical Research;Data Science;Depression;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

ORG_STATE: PA

PHR: PROJECT NARRATIVE The mission of the PsycheMERGE Network is to advance equitable precision psychiatry in learning healthcare system frameworks across the United States. During the course of this project, an interdisciplinary team of investigators at twelve academic medical centers will bring together clinical data (>29 million individuals), genetic data (>1.9 million), and an extraordinary range of scientific expertise (psychiatry, medical informatics, machine learning, statistics, genetics, sociomedical sciences, decision sciences, and ethics) to advance this mission. We will leverage this expertise and data to build on our prior success and address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice.

PI_NAMEs: CHABRIS, CHRISTOPHER F. (contact)

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acute;Address;algorithm training;Algorithms;anti-depressive agents;Artificial Intelligence;artificial intelligence method;Attitude;Awareness;Basic Science;Big Data;biobank;Biology;Biomedical Research;Bipolar Disorder;Bipolar I;causal variant;Clinical;clinical application;Clinical Data;clinical decision support;clinical practice;Communities;Country;Data;data privacy;depressive symptoms;Development;Diagnosis;Diagnostic;Differential Diagnosis;disability;Disease;Early Diagnosis;Early treatment;effective therapy;Effectiveness;Environment;Equity;Ethics;experience;federated learning;Funding;Genes;Genetic;genetic analysis;genetic association;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Health system;Healthcare Systems;improved;Individual;individual variation;Infrastructure;innovation;Label;large scale data;Learning;Left;Life Style;Machine Learning;machine learning algorithm;Maps;Medical;Medical Informatics;Medical Records;member;Mental disorders;Methods;Midwestern United States;Mission;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;network models;novel;Outcome;Patients;Pattern;Performance;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Prevention;privacy preservation;Process;Psychiatric Diagnosis;Psychiatry;Records;Research Personnel;response;risk prediction;Sampling;Science;Scientist;Site;social health determinants;Standardization;statistics;Strategic Planning;success;support tools;Testing;Time;tool;Training;transfer learning;Translational Research;Translations;treatment response;United States;Update;Validation;Vision;Work

PROJECT_TITLE: 7/7-PsycheMERGE: Advancing Precision Psychiatry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Patient Safety;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Tailoring cancer therapy to allow the best cure with the fewest side effects is one of the highest priorities in cancer care. Unfortunately, even radiation therapy, one of the most widely used cancer therapies, although very technologically advanced, has not had biomarkers to identify those at increased risk of toxicity. We have identified a new class of biomarkers that predict significant late toxicity risk to radiation therapy in prostate cancer, and believe that further validating, defining and understanding these biomarkers, as well as applying the most advanced technologies for treatment of these patients, will radically improve our ability to meaningfully decrease toxicity for prostate cancer radiation treated patients in the near future.

PI_NAMEs: KISHAN, AMAR U (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Acute;acute toxicity;Area;Biological;biological adaptation to stress;Biological Markers;Biology;biomarker panel;cancer care;Cancer Etiology;Cancer Patient;cancer radiation therapy;cancer therapy;Cells;Chronic;Clinical;Clinical Trials;cohort;Collection;Complex;Data;Diagnosis;DNA;Dose;Evaluation;experience;Future;gastrointestinal;Gene Expression;Genetic;genetic signature;Genitourinary system;Genome;Germ Lines;Goals;high risk;immune cell infiltrate;improved;Incidence;Individual;individual patient;Institution;Intervention;Intestines;Life;Linear Accelerator Radiotherapy Systems;Localized Disease;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;MicroRNAs;Modernization;Morbidity - disease rate;Neoadjuvant Therapy;Normal tissue morphology;Organ;patient subsets;Patients;personalized cancer therapy;Phase;Phase I Clinical Trials;Physicians;predictive marker;prevent;prospective;Prostate;Prostate Cancer therapy;Quality of life;Radiation;Radiation Dose Unit;Radiation exposure;radiation response;Radiation therapy;Radiation Therapy Oncology Group;Radiation Tolerance;Radiation Toxicity;Radiobiology;Randomized;randomized trial;Reporting;Request for Proposals;Research;Risk;side effect;Single Nucleotide Polymorphism;specific biomarkers;Specimen;standard care;standard of care;Structure;Subgroup;Symptoms;Technology;Tissue Sample;Tissue Therapy;Toxic effect;Translating;treatment response;Treatment-Related Cancer;Treatment-related toxicity;United States;Untranslated RNA;urinary;Work;years lived with disability

PROJECT_TITLE: Reducing toxicity from prostate cancer radiotherapy through genetics and technology

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The primary objective of this project is to determine how the formation of heterochromatin is driven by targets of the degradative ubiquitin ligase anaphase-promoting complex (APC), including Ki-67 and phosphorylated histone 3. The elegant experiments we propose aim to test the hypothesis that these APC-targets drive heterochromatin formation by promoting the biophysical process of phase separation. Achieving these aims will provide fundamental insight into the role of chromatin regulation in neurons and the contribution of this process to inherited disorders of neurodevelopment.

PI_NAMEs: FERGUSON, COLE JOHN (contact)

PROJECT_TERMS: Alleles;anaphase-promoting complex;aurora B kinase;Behavior;Binding;Biology;Biophysical Process;Brain;Cell Nucleolus;Cell Nucleus;Cells;Charge;Chromatin;chromatin modification;Chromosomes;Complex;Computing Methodologies;Data;Development;Disease;DNA;epigenetic regulation;Exhibits;experimental study;Fluorescence Recovery After Photobleaching;Foundations;Gene Modified;Genetic;Genome;genome-wide;Genomics;Health;Hereditary Disease;Heterochromatin;Histones;Image;image reconstruction;in vitro Assay;in vivo;infancy;innovation;insight;interest;Length;Liquid substance;live cell imaging;LoxP-flanked allele;Measures;Mediating;Membrane;Methods;Mitosis;Molecular;Molecular Analysis;Molecular Conformation;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;next generation sequencing;novel;Nucleosomes;Online Mendelian Inheritance In Man;Organelles;Pathogenesis;Patients;Phase;Phosphoproteins;Phosphorylation;Physical condensation;postmitotic;Process;Proteins;Recombinant Proteins;Regulation;Role;scaffold;Series;Signal Transduction;Syndrome;System;Testing;Time;tool;Ubiquitin;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Regulation of phase separation in neuronal heterochromatin

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Down syndrome (DS), caused by triplication of chromosome 21, is the most common intellectual disability disorder affecting more than 250,000 individuals in the United States alone. Abnormalities in brain development and metabolic dysregulation are hallmarks of DS, and emerging evidence suggests that metabolism plays a key role in brain development, yet the consequence of altered cellular metabolism on brain development in the context of DS is unknown. This project will support the NIH’s mission to seek fundamental knowledge about the nature of living systems and apply that knowledge to advance human health by exploring the consequence of altered cellular metabolism on neural progenitor cell proliferation and fate specification in brain development to gain insight into the pathogenesis of DS and enhance health outcomes for individuals suffering from the disorders.

PI_NAMEs: MEHARENA, HIRUY SIBHATU (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 3-Dimensional;Acetyl Coenzyme A;Address;Affect;Aneuploidy;autism spectrum disorder;Behavioral;Brain;cancer cell;Cell Differentiation process;cell fate specification;cell type;Cellular Membrane;Central Nervous System;Cholesterol;Cholesterol Homeostasis;Chromatin;Chromosome 21;Cognitive;Cognitive deficits;Communities;Complex;Cues;Development;Diabetes Mellitus;Disease;Down's Syndrome;Epigenetic Process;Etiology;Exhibits;fetal;Functional disorder;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Genome;genome-wide;Global Change;Glucose;Glycolysis;Goals;Health;Histone Acetylation;histone acetyltransferase;Human;human stem cells;Hypoxia;Impaired cognition;improved;In Vitro;in vivo;Incidence;Individual;induced pluripotent stem cell;insight;Intellectual functioning disability;Internships;Intracellular Accumulation of Lipids;Knowledge;lipid metabolism;Lipids;Maps;member;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mission;Molecular;Morphogenesis;mouse model;Mus;Nature;nerve stem cell;neural;neural circuit;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;Nuclear;Obesity;Organism;Organoids;Outcome;Pathogenesis;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Play;Population Heterogeneity;Process;Production;programs;Proliferating;Property;Regulation;Research;Research Project Grants;Rewards;Role;sensor;single-cell RNA sequencing;Specific qualifier value;stem cell fate specification;stem cell model;stem cell proliferation;student participation;Students;Testing;Therapeutic;Tissues;underserved students;United States;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Nuclear-Metabolic Interplay in Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative You see because light from objects in your environment evokes electrical signals in the retina of your eye. The brain decodes these signals to analyze what those objects are, but because the eye is moving all the time, the brain cannot decode where those objects are in the world without using information about how the eye moves and where it is located in the skull when it moves. This project will apply physiological and neuropsychological methods to investigate the brain network that creates an accurate representation of the world around us for memory and action, and which goes awry in patients with certain brain lesions of the cerebral cortex.

PI_NAMEs: GOLDBERG, MICHAEL E. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Area;Back;Brain;Categories;Cell Separation;cell type;Cells;Cerebral cortex;Cognitive;cognitive neuroscience;Compensation;Contralateral;cranium;Data;Development;entorhinal cortex;Environment;Exhibits;experimental study;Eye;Eye Movements;Feedback;feeding;gaze;Generations;Head;Hippocampus;Human;Impairment;lateral intraparietal area;Lesion;Light;Location;Maps;Measures;member;Memory;Memory impairment;Methods;Modernization;Monkeys;Motor;Neurons;Neuropsychology;nonhuman primate;novel;Ocular orbit;oculomotor;Parahippocampal Gyrus;Patients;Perception;Physiological;Positioning Attribute;Process;Production;Property;Proprioception;Proprioceptor;Psychophysics;Published Comment;receptive field;response;Retina;retinotopic;Rodent;Role;Saccades;sample fixation;sensor;sensory system;Signal Transduction;somatosensory;Somatosensory Cortex;spatial memory;Stimulus;Suggestion;System;Testing;Time;virtual reality environment;Visual;visual memory;Visual System;Visuospatial

PROJECT_TITLE: The Role of Oculomotor Proprioception in the Establishment of Long-Term Visuospatial Memory

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE We recently showed that chronic mild hypoxia (CMH; 10% O2) accelerates clinical recovery in the multiple sclerosis (MS) mouse model, experimental autoimmune encephalomyelitis (EAE), leading to long-term stable reductions in clinical score, in part due to enhanced vascular integrity and apoptotic removal of infiltrated monocytes. As we have recently shown that hypoxia mimetics, drugs that stimulate hypoxia signaling pathways, confer similar protection, here we plan to explore the therapeutic potential of this finding and define the underlying mechanisms responsible by testing the hypothesis that hypoxia mimetics promote recovery from inflammatory demyelinating disease by enhancing vascular integrity and suppressing neuroinflammation via HIF-mediated signaling. The proposed research is relevant to public health and the mission of NIH because it is expected to lead to the development of novel therapeutic approaches aimed at treating MS.

PI_NAMEs: MILNER, D. RICHARD (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acceleration;angiogenesis;Apoptosis;Apoptotic;axonal degeneration;Biotinylation;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Cells;cellular targeting;Central Nervous System;Chronic;chronic inflammatory disease;Clinical;Demyelinating Diseases;Demyelinations;Development;disability;Disease;Disease remission;Dose;Drug or chemical Tissue Distribution;Endothelium;Event;Excision;Experimental Animal Model;Experimental Autoimmune Encephalomyelitis;experimental study;Flow Cytometry;Goals;HIF1A gene;Histologic;Hypoxia;Hypoxia Inducible Factor;Immunofluorescence Immunologic;immunological status;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Knockout Mice;Leucocytic infiltrate;Leukocytes;Maintenance;Mediating;middle age;mimetics;Mission;Modeling;monocyte;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;neuroinflammation;Neurologic;neurological recovery;novel;novel therapeutic intervention;optimal treatments;Pathogenesis;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Play;Proteins;Protocols documentation;Public Health;Recovery;Relapse;remyelination;Research;response;Role;Signal Pathway;Signal Transduction;Testing;Therapeutic;Tight Junctions;translational potential;Treatment Protocols;United States National Institutes of Health;Vascular Cell Adhesion Molecule-1;vascular contributions;Vascular remodeling

PROJECT_TITLE: Evaluating the therapeutic potential of hypoxia mimetics in inflammatory demyelinating disease

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Few adolescent girls and young women (AGYW, ≥16 to 24 years) at risk of HIV acquisition are initiating pre- exposure prophylaxis (PrEP) for HIV prevention in Kenya. Thus, in the R00 parent award of this supplement application, we proposed refining and testing a new model to increase PrEP initiation among AGYW at HIV risk that has never been explored: formalized peer PrEP referral + HIV self-test delivery. Unexpected implementation challenges (e.g., approval delays, participant recruitment challenges), however, have had cost implications for this award so we are requesting additional resources to complete the proposed R00 parent award research on time and generate high-quality evidence on how to engage an important population in PrEP services.

PI_NAMEs: ORTBLAD, KATRINA FRANCES (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrative Supplement;Adoption;Africa;Africa South of the Sahara;African;AIDS prevention;arm;Award;behavior influence;Blood;budget impact;career;Caring;Client;Clinic;Clinical;Clinical effectiveness;Collaborations;Communities;cost;Country;County;Decision Making;design;Diagnostic Reagent Kits;Dryness;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation study;Enrollment;Ensure;Epidemic;Female;Female Adolescents;female sex worker;Focus Groups;follow-up;Government;Guidelines;Health;Healthcare;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;implementation barriers;implementation outcomes;implementation science;implementation strategy;Incidence;Individual;innovation;Institution;interest;International;Intervention;intervention refinement;Kenya;Knowledge;Measures;meetings;Modeling;multidisciplinary;new technology;Outcome;parent project;Patient Recruitments;peer;peer networks;Phase;Pilot Projects;pilot test;Population;pre-exposure prophylaxis;preference;prevention service;preventive intervention;Principal Investigator;Provider;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Risk;scale up;Self Efficacy;self testing;Services;social;social stigma;Spottings;supply chain;Surveys;Testing;Time;Training;Translations;treatment services;trial design;United States National Institutes of Health;uptake;Woman;young woman

PROJECT_TITLE: Peer PrEP referral + HIV self-test for PrEP initiation among young Kenyan women


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Nutrition;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative To combat malaria, new discoveries of parasite biology are highly desirable, especially those from the less studied lifecycle stages. We have discovered that an ancient proton pumping pyrophosphatase (PfVP1) is essential for ring stage development. We will investigate the mechanisms by which malaria parasites utilize pyrophosphate, but not ATP, as the energy source to pump protons and generate plasma membrane potential.

PI_NAMEs: KE, HANGJUN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Active Biological Transport;Affect;Agreement;Amino Acids;Anti-malarials;Archaea;asexual;Asexual Reproduction;Bacteria;Biology;Blood Circulation;Budgets;Case Study;Cell membrane;Cells;Cessation of life;Charge;combat;Complex;Cytolysis;Data;Defect;Development;Diphosphates;Disease;DNA biosynthesis;drug development;Drug resistance;Energy Metabolism;Energy-Generating Resources;Environment;Enzymes;Erythrocytes;experimental study;fungus;genetic approach;global health;Glycolysis;Growth;Hour;Human;Hydrolysis;in vitro activity;in vivo;inhibitor;insight;Invaded;knock-down;Laboratories;Life Cycle Stages;Malaria;Mammalian Cell;Mass Spectrum Analysis;Measures;Membrane;Membrane Potentials;Metabolic;Metabolism;Molecular;Morbidity - disease rate;mortality;Movement;mutant;Mutate;Mutation;Na(+)-K(+)-Exchanging ATPase;Nature;Nutrient;Organelles;Orthophosphate;Outcomes Research;Parasites;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Plants;Plasmodium;Plasmodium falciparum;Play;Polyacrylamide Gel Electrophoresis;Polyphosphates;Polyps;Population;Production;Proteins;Proton Pump;Protons;Protozoa;Pump;pyrophosphatase;Reaction;recruit;Research;Research Proposals;RNA;Role;Route;Series;solute;Spleen;Surface;System;Testing;Time;Toxoplasma gondii;Transport Process;vacuolar H+-ATPase;Variant;Yeasts

PROJECT_TITLE: Proton pumping and energy metabolism of the ring stage malaria parasites

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Mental Health

PHR: PROJECT NARRATIVE The field of psychobiology lacks robust, biologically informative biomarkers to evaluate the emerging role of mitochondria in the stress-disease cascade. We have assembled an interdisciplinary team of psychosocial, clinical, and mitochondrial scientists to examine the psychobiological regulation of cell-free mitochondrial DNA (cf-mtDNA) and validate dynamic features of stress-evoked cf-mtDNA responses across thousands of samples from healthy women and men. The combined i) multi-study psychosocial challenge approach, including nested (quasi)experimental manipulations of mitochondrial energy metabolism, ii) novel discovery-based human stress proteome analyses, and iii) laboratory experiments to dissect the molecular nature of cf-mtDNA, will provide foundational knowledge to develop novel markers of mitochondrial biology, which can subsequently be deployed at scale in clinical and epidemiological studies aiming to understand the basis of human health, resilience, and vulnerability to disease.

PI_NAMEs: PICARD, MARTIN  (contact);TRUMPFF, CAROLINE

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Anxiety;anxiety symptoms;aptamer;Biochemical;Bioenergetics;Biological;Biological Markers;Biology;Blood;Blood Cells;Blood specimen;Body System;Brain;Calibration;Cell Density;Cell Shape;cell type;Cells;Cellular biology;Characteristics;Clinical;Clinical Research;cohort;combinatorial;Cues;cytokine;Cytolysis;Data;Data Set;Defect;density;depressive symptoms;dietary manipulation;Disease;disorder risk;DNA;Electron Microscopy;Encapsulated;Endocrine;Energy Metabolism;epidemiology study;Exhibits;experimental study;Exposure to;extracellular vesicles;Fractionation;Funding;Gender;Genetic;Health;High Density Lipoproteins;Human;Hydrocortisone;Image;Immune;Individual;insight;inter-individual variation;Interphase Cell;Knowledge;Laboratories;laboratory experiment;LDL Cholesterol Lipoproteins;Life Stress;Link;Maps;Measurement;Measures;men;Mental disorders;Mental Health;mental state;Metabolic;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial Proteins;Molecular;Molecular Sieve Chromatography;Moods;Morphology;nanoparticle;National Institute of Mental Health;Nature;Neurosecretory Systems;novel;novel marker;Organism;particle;Pathway interactions;Pattern;Persons;Phenotype;Physiological;Population Heterogeneity;Positioning Attribute;Protein Family;Proteins;Proteome;Proteomics;Protocols documentation;Psyche structure;psychobiologic;psychobiology;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;Quasi-experiment;Recovery;Regulation;Research;Research Personnel;resilience;Resolution;response;Role;Saliva;saliva sample;salivary cell;Sampling;Scientist;sex;Sex Differences;Signal Transduction;Source;Specificity;Standardization;Stress;stress reactivity;stressor;System;Technology;Testing;trait;Validation;Visit;Woman;Work

PROJECT_TITLE: Psychobiological regulation and molecular characterization of cell-free mitochondrial DNA in humans

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative This proposal seeks to understand, at the level of cells and neural circuits, how visual information is detected and processed by the visual system so that it can contribute to our perception of the world around us. The discoveries made by this proposal regarding the function and organization of healthy visual system circuits will facilitate our understanding of how these circuits could be impacted by disease, and will help speed the advent of therapies designed to treat damage to, and diseases that afflict, the visual system and lead to blindness. More generally, understanding the mechanisms and neural circuits responsible for normal functioning of the visual system has important implications for a range of other diseases in other parts of the nervous system where impairment in the function of neural circuits has been implicated.

PI_NAMEs: CALLAWAY, EDWARD M;STAFFORD, BENJAMIN KNOELL (contact)

PROJECT_TERMS: area striata;Behavior;Blindness;Brain;Calcium;cell type;Cells;Disease;Dorsal;dorsal visual stream;experimental study;Eye;Generations;Genetic;Goals;Image;Impairment;innovative technologies;Label;Lateral Geniculate Body;Link;Maps;Molecular;molecular marker;Motion;Mus;Nervous System;neural circuit;Neurons;Neurophysiology - biologic function;novel;orientation selectivity;Output;Pathway interactions;Perception;Population;Process;programs;Property;Research;response;Retina;Retinal Ganglion Cells;retinogeniculate;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Speed;systems research;Testing;Thalamic structure;therapy design;transcriptomics;transmission process;two-photon;V1 neuron;Viral;Vision;Visual;visual information;Visual Pathways;Visual Perception;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Organization of Retinothalamic Circuits and their Contributions to Visual Processing in Primary Visual Cortex


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: We propose to test a program (Conmigo) to increase physical activity among girls ages 8-11 and their mothers. The study aims to understand how effective the program is, how families are involved, and any challenges in putting the program into practice. This program is pertinent to public health as it addresses health disparities stemming from limited family and community-level support.

PI_NAMEs: ARREDONDO, ELVA M (contact)

PROGRAM_OFFICER_NAME: HALL, KARA L

PROJECT_TERMS: Accelerometer;Acculturation;Address;Adolescence;Adoption;Age;aged;arm;attentional control;Behavioral;Child;Child Rearing;Chronic Disease;Collaborations;Communication;Communities;community collaboration;community organizations;community setting;Daughter;design;effectiveness outcome;effectiveness testing;effectiveness/implementation design;Eligibility Determination;evidence base;exercise intervention;expectation;experience;Family;Family health status;family influence;family support;feasibility trial;follow-up;Funding;Future;Gender Role;girls;Guidelines;Habits;Health behavior;health disparity;Hybrids;implementation barriers;implementation evaluation;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Individual;Intervention;Interview;Latina;Latina Population;Leadership;Learning;Longterm Follow-up;Low income;Measures;member;Mental Health;Methods;Mission;moderate-to-vigorous physical activity;Mothers;nutrition;Outcome;Participant;Phase;Physical activity;post intervention;preadolescence;prepuberty;Process;programs;protective factors;Public Health;Research;Resources;Risk;Risk Factors;school health;Schools;Site;Spanish;stem;Testing;Time;Training;treatment arm

PROJECT_TITLE: Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent Latinas

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Lack of representation of racial and ethnic minorities in genetic repositories, association studies, and prediction models results in their unequal benefit from medical and technological advancements, thus contributing to the persistence of health disparities. We will develop accessible methods to explore and meta-analyze data from diverse biobanks through a common coded language called phecodes and optimize phecode resolution for eye disease phenotypes (eye phecodes) with the hopes of reducing ocular health disparities. We will share these tools to allow others to practically leverage biobank data to explore ophthalmic disease patterns, associations, and disparities with results that are reliable, reproducible, and generalizable.

PI_NAMEs: PADOVANI-CLAUDIO, DOLLY ANN (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Acceleration;Adopted;Affect;African ancestry;Age related macular degeneration;Algorithms;Area;Arthritis;Awareness;biobank;Biological;case control;Catalogs;Categories;Clinical;clinical diagnosis;Clinical Management;clinical predictive model;clinically relevant;Code;cohort;comorbidity;Complex;Controlled Vocabulary;Data;data modalities;data resource;demographic disparity;demographics;Detection;diabetic;Disease;disease disparity;disease phenotype;disorder risk;disorder subtype;Disparity;Disparity population;diverse data;Electronic Health Record;electronic health record system;Epidemiology;ethnic minority;Ethnic Origin;European ancestry;Eye;Eye diseases;Gender;Genetic;genetic association;genetic risk factor;genetic variant;Genome;genome wide association study;genomic data;Genomics;Genotype;Glean;Goals;Grouping;Health;health disparity;Hispanic;hypertensive;improved;Individual;Inflammatory;International Classification of Disease Codes;Iritis;Knowledge;Language;Latino Population;Link;Literature;macular edema;Manuals;Maps;Medical;Methods;Morbidity - disease rate;National Eye Institute;novel;Ontology;Pathway interactions;Pattern;Performance;phenome;phenomics;Phenotype;Population Heterogeneity;predictive modeling;Procedures;Production;Publishing;Race;racial minority;Radiation;Rare Diseases;Reliability of Results;repository;Reproducibility;Research;Resolution;Retinal Diseases;Risk;Risk Factors;risk prediction model;Running;Sampling;Science;Sensitivity and Specificity;social;statistics;Strategic Planning;Structure;Study models;Technology;Testing;tool;Toxoplasma;trait;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Update;Uveitis;Validation;Vision;vision science;web site;Work

PROJECT_TITLE: Biobank phenotyping tools for improved understanding and management of eye diseases and disparities

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PHR: PROJECTIVE NARRATIVE Pancreatic cancer is an aggressive, devastating malignancy with despondent morbidity and mortality. While there have been advancements in clinical imaging, histology, and cellular/molecular profiling, these advancements have occurred largely independent of one another, thus there is a need to integrate these to provide a more causal understanding of how clinical imaging phenotypes relate to pancreatic adenocarcinoma subtypes from more to less aggressive subtypes, and in the process establish “molecular omic-type to clinical phenotype” relationship in order to find new strategies to diagnosis and treat the disease. The work in this proposal will use cutting-edge cellular and tissue measurements of the microenvironment of pancreatic adenocarcinoma (PDAC) with computational systems biology (using integrated transcription, signaling, and metabolic networks), focusing on the of glycolytic and inflammatory characteristics of tumors in relation to specific histological tumor characteristics, in order to 1) develop a non-invasive imaging test (i.e. anatomical and metabolic imaging through PET/CT) to identify PDAC phenotypes that 2) lead to new potential cellular targets for treatment in the future.

PI_NAMEs: JAMSHIDI, NEEMA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;anatomic imaging;Anatomy;Architecture;Attention;Benchmarking;Binding;Biochemical Pathway;Biological Assay;Biological Models;cancer imaging;Cell Line;Cell model;Cells;cellular imaging;cellular targeting;Characteristics;chemotherapy;Classification;Clinical;clinical imaging;Clinical Management;clinical phenotype;Clinical/Radiologic;Coculture Techniques;Confocal Microscopy;Data;data integration;data-driven model;Desmoplastic;Diagnosis;Diagnostic;Dimensions;Discipline;Disease;Disparate;Distant;DNA Sequence Alteration;E-Cadherin;Environment;epithelial to mesenchymal transition;Epithelium;follow-up;Future;Genetic Transcription;genome-wide;Histologic;Histology;Histopathology;Image;imaging approach;imaging modality;in silico;In Vitro;in vivo;Individual;Inflammatory;inflammatory marker;Invaded;Lesion;Light;Link;lymphatic Invasion;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mesenchymal;Metabolic;metabolic imaging;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Microfluidics;Microscopy;migration;Modality;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;Morbidity - disease rate;mortality;multiple data types;N-Cadherin;neoplastic cell;non-invasive imaging;Non-Malignant;Normal tissue morphology;novel;Operative Surgical Procedures;Organ;Organelles;Pain;Pancreatic Adenocarcinoma;Pathology;patient derived xenograft model;Patients;perineural;PET/CT scan;Phenotype;Population;Positioning Attribute;Positron-Emission Tomography;predictive modeling;preservation;Process;prognostic;prognostic value;radiological imaging;Radiology Specialty;reconstruction;Resources;response;Signal Pathway;Signal Transduction;simulation;skills;Small Interfering RNA;Specimen;Stromal Cells;success;survival outcome;Survival Rate;System;Systems Biology;Testing;therapeutic target;Time;Tissue imaging;Tissues;transcription factor;transcriptomic profiling;transcriptomics;treatment strategy;tumor;tumor microenvironment;Validation;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Systems Metabolic Approach for Multi-scale Pancreatic Cancer Phenotyping

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Radiation Oncology

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T-cell therapy is a groundbreaking treatment that has proven to be lifesaving for patients with blood cancers. This project is about making this treatment effective for patients with hard-to-treat solid tumors by integrating endoradiotherapy into CAR-T cell therapy. Our goal is to optimize this combinatorial therapy to enhance clinical benefits while minimizing adverse effects.

PI_NAMEs: JIN, MOONSOO M.;YANG, YANPING  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Abscopal effect;Address;Adverse effects;Affinity;Animal Model;anti-tumor immune response;Antigen Targeting;Antigens;Automobile Driving;behavioral phenotyping;Biphasic Pattern;Cancer Patient;cancer therapy;CAR T cell therapy;Case Study;Cells;cellular imaging;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;combinatorial;Combined Modality Therapy;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Disease;Dose;dosimetry;Effectiveness;Engineering;exhaustion;Exhibits;Extravasation;fighting;Flow Cytometry;Fostering;Functional disorder;Gene Expression;Genetic Engineering;Goals;Growth;Harvest;Hematologic Neoplasms;Hematopoietic Neoplasms;image guided;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunohistochemistry;immunoregulation;Immunotherapy;improved;Individual;Induction of Apoptosis;Infiltration;innovation;insight;Interferon Type II;Investigation;Kinetics;Lesion;Life;Ligands;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;Medicine;Melanoma;Modeling;Molecular;mouse model;multiple omics;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel strategies;Octreotide;Pathway interactions;Patient-Focused Outcomes;Patients;perforin;phase 1 study;Positron-Emission Tomography;Predisposition;Production;Proliferating;Radiation;radiation delivery;Radiation Dose Unit;radiation effect;Radiation therapy;Radioimmunotherapy;Radionuclide therapy;randomized, clinical trials;Refractory;Reporter;Resistance;response;safety testing;Sampling;Serum;Shapes;Solid;Solid Neoplasm;somatostatin receptor 2;spatiotemporal;Structure;success;Surface;synergism;Systemic disease;T cell infiltration;T-Lymphocyte;targeted delivery;Targeted Radiotherapy;Techniques;theranostics;TNF gene;tumor;Tumor Antigens;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor Necrosis Factor Ligand Superfamily Member 6;Tumor Promotion;tumor-immune system interactions;United States Food and Drug Administration;uptake;Work;X-Ray Computed Tomography

PROJECT_TITLE: Enhancing CAR-T cell therapy through theranostic targeted radionuclide therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Prevention;Primary Health Care

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Type-2 diabetes (T2D) is growing in an alarming rate in urban areas in many low and middle-income countries such as Bangladesh, leading to a higher risk for premature deaths, disability, and poverty. Evidence-based WHO guideline exists to help control T2D, yet effective strategies to adopt and sustain this recommended practice into routine urban primary care are unavailable – highlighting a major global unmet need for rigorous implementation research data. Our study addresses this gap and aims to evaluate the implementation and effectiveness outcomes of an integrated community-to-facility strategy for implementing the WHO best practices (HEARTS-D module) in Bangladeshi cities and other similar settings.

PI_NAMEs: CHOWDHURY, RAJIV  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acceleration;Address;Adherence;Adopted;Adoption;Adult;arm;Asia;Awareness;Bangladesh;Bangladeshi;Blood Glucose;Caring;Cessation of life;Characteristics;Chronic;Cities;Cluster randomized trial;Collaborations;Communities;Community Health Aides;compare effectiveness;Comparison arm;Complications of Diabetes Mellitus;contextual factors;Country;Data;Detection;diabetes control;Diabetes prevention;disability;Disadvantaged;Disease;Disease Management;Economics;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;Elements;Ensure;Environment;Equity;evidence base;Face;Glucose;glycemic control;Goals;Government;Guidelines;Health;Health care facility;health inequalities;Health system;high risk;Human;implementation barriers;implementation evaluation;implementation outcomes;implementation process;implementation research;implementation strategy;improved;intervention cost;Learning;low and middle-income countries;Maintenance;Maps;Measurement;member;Metabolic;Methods;Monitor;Municipalities;Non-Insulin-Dependent Diabetes Mellitus;novel;organizational structure;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Policy Maker;Population;Poverty;premature;Prevalence;Primary Care;primary care provider;programs;Provider;provider behavior;Qualitative Methods;Quality of Care;Random Allocation;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;response;rural area;Sampling Studies;service delivery;Service provision;Structure;System;Training;Trust;uptake;urban area;Urbanization;ward;World Health Organization

PROJECT_TITLE: Leveraging community-to-facility service provision to implement the World Health Organization HEARTS-D guidelines in Bangladesh for improving diabetes control and prevention.

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it introduces new strategies for systematically addressing the factuality and unfaithful reasoning of Large Language Models (LLMs) – the main barriers to using LLMs in biomedicine and healthcare applications, and posing the risk of spreading misinformation, potentially leading to misdiagnosis or incorrect treatment recommendations. The research will establish a foundation for advancing LLMs, ensuring they provide more accurate and trustworthy responses to support biomedical discovery and healthcare, refine the current development and evaluation processes of LLMs in the biomedical and health domains, and provide resources including benchmarks, methods, and tools to the community. Therefore, the proposed research aligns with the National Library of Medicine (NLM)'s mission to develop innovative biomedical informatics and data science methods, including natural language processing, artificial intelligence, and LLMs, to advance biomedical discovery and data-powered health.

PI_NAMEs: CHEN, QINGYU  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Accountability;Address;Artificial Intelligence;artificial intelligence method;Benchmarking;biomedical informatics;chatbot;ChatGPT;Communities;Data;Data Science;Decision Making;Development;digital;disease diagnosis;Educational process of instructing;Effectiveness;empowerment;Ensure;Evaluation;evidence base;Feedback;Foundations;Generations;Goals;Grain;Health;health application;Healthcare;Human;implementation facilitation;improved;innovation;Instruction;Knowledge;knowledgebase;large language model;Life Cycle Stages;Medical;method development;Methods;Misinformation;Mission;Modeling;multitask;natural language;Natural Language Processing;Outcome;Process;programs;Public Health;Reaction;Reading;reading comprehension;Recommendation;Reporting;Research;Resources;response;Risk;Self Assessment;Self Perception;software development;Source;systematic review;terabyte;Text;tool;Training;Translations;trustworthiness;United States National Library of Medicine;Work;Writing

PROJECT_TITLE: Addressing Factual Inaccuracy and Unfaithful Reasoning of Large Language Models in Biomedicine and Healthcare

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Pancreatic cancer is the third leading cause of cancer mortality in the United States, and there are urgent needs to identify causally related protein biomarkers and build improved prediction models for pancreatic cancer risk. The proposed study will identify causally related protein biomarkers for pancreatic cancer using an innovative design of combining novel statistical methods and functional characterization and develop improved pancreatic cancer risk prediction models using novel methods. Knowledge generated by this project will not only significantly contribute to the etiologic understanding of pancreatic cancer, but also have potential utility in improving its risk assessment.

PI_NAMEs: WU, CHONG ;WU, LANG  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Animal Model;Apoptosis;Area;Assessment tool;Basic Science;biobank;Bioinformatics;Biological Markers;biomarker identification;Blood;Brain;Cancer Biology;cancer cell;Cancer cell line;Cancer Etiology;cancer risk;candidate identification;candidate marker;Cell Line;Cell Proliferation;clinically relevant;Cohort Studies;Data;Databases;Derivation procedure;design;Development;Disease;disorder risk;epidemiologic data;epidemiology study;Etiology;experience;Freezing;gain of function;Genes;Genetic;genetic approach;genetic predictors;high risk population;improved;In Vitro;in vivo;innovation;Invaded;Knowledge;lifestyle factors;loss of function;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Measures;Methodology;Methods;migration;model building;Modeling;mortality;multi-ethnic;multiple omics;non-genetic;novel;Organoids;Other Genetics;Pancreas;pancreatic cancer cells;pancreatic cancer model;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathogenesis;Patients;Performance;Population;Positioning Attribute;predictive marker;predictive modeling;programs;Property;prospective;protein biomarkers;protein expression;Proteins;Proteome;Regulator Genes;Research Design;Research Support;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Role;screening;Screening for cancer;Selection Bias;Series;Statistical Methods;Study models;Testing;Tissues;transcriptome;tumor progression;Tumor Promotion;Tumor-Derived;United States;Validation;Work

PROJECT_TITLE: Uncovering Causal Protein Markers to Characterize Pancreatic Cancer Etiology and Improve Risk Prediction

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative If science is to inform effective child protection policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers’ use of research evidence, yet our field lacks an evidence- based model designed for this purpose. Accordingly, we propose a state-level randomized controlled trial (N = 30 states) of a formal, theory-based approach for appropriately supporting policymakers’ use of scientific evidence--known as the Research-to-Policy Collaboration (RPC) Model. This work has the potential to reduce population-level child maltreatment and protect children by improving the use of scientific information in policymaking, thus increasing the availability of evidence-based prevention programs and policies.

PI_NAMEs: CROWLEY, DANIEL MAX;SCOTT, JENNIFER TAYLOR (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adoption;Affect;Awareness;Behavior;behavioral health;care systems;Child;Child Abuse and Neglect;child protection;Child Support;Code;Collaborations;Communities;Complement;Congresses;Effectiveness;effectiveness evaluation;effectiveness research;Equity;evidence base;Evidence based program;experience;experimental study;foster care;Fostering;Frequencies;Funding;Harm Reduction;improved;Incentives;Inequity;Infant Mortality;insight;Intervention;Interview;Investigation;Language;Lobbying;Maps;Mental Health;Methods;model design;Modeling;National Institute of Child Health and Human Development;neglect;Outcome;outreach;Perception;physical conditioning;Policies;Policy Maker;Policy Making;Population;prevent;Prevention program;Primary Prevention;Process;Productivity;Protocols documentation;Public Health;Randomized, Controlled Trials;Research;Research Personnel;Research Support;Resources;response;Science;service delivery;Services;Sexual abuse;social disparities;societal costs;Statutes and Laws;Surveys;Survivors;Testing;theories;Time;time use;Translations;Trauma;Voting;wasting;Work

PROJECT_TITLE: Experimental Study of a Model to Support Research Evidence Use for Protecting Children

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Temporal Interference (TI) is a non-invasive brain stimulation method with transformative potential for deep brain stimulation in neurological and neuropsychiatric disorders. This proposal aims to bridge the gap between theory and practice by investigating TI's mechanisms, its deep brain stimulation capabilities, frequency-dependent effects, and influence on brain components. Ultimately, our investigation into TI's mechanisms and efficacy promises a better understanding of this new non-invasive neuromodulation technique for both research and clinical applications.

PI_NAMEs: BERGLUND, KEN ;GUTEKUNST, CLAIRE-ANNE N (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Ablation;Affect;Anesthesia procedures;Autopsy;Axon;Brain;Brain region;Calcium;Cell Compartmentation;Cell Nucleus;cell type;Cells;Cellular Membrane;Central Nervous System;Clinical;clinical application;Corpus striatum structure;Deep Brain Stimulation;Effectiveness;electric field;Electrodes;Electrophysiology (science);Elements;experimental study;Fiber;fluorescence imaging;FOS gene;Frequencies;frontier;Genes;Genetic;Glutamates;Hippocampus;Histology;Image;imaging genetics;Imaging Techniques;Immediate-Early Genes;in silico;In Vitro;in vivo;Injections;innovation;Investigation;JUN gene;Knowledge;Medial;Membrane Potentials;Methods;Microelectrodes;Microfluidics;Modeling;Monitor;Mus;Nervous System Disorder;neural;neuronal cell body;Neurons;neuropsychiatric disorder;neuroregulation;noninvasive brain stimulation;Pathway interactions;Pattern;Perforant Pathway;Peripheral Nerve Stimulation;Peripheral Nervous System;Positioning Attribute;practical application;Process;Proxy;Reporter;Research;Research Personnel;Research Project Grants;response;Role;sensor;septohippocampal;Signal Transduction;simulation;Slice;Specificity;Speed;stem;Structure;success;Techniques;theories;Time;Tissues;Transgenic Organisms;two-photon;Viral;Viral Vector;voltage

PROJECT_TITLE: Advancing non-invasive brain stimulation: A CompreheNSive Study of Temporal Interference Mechanisms (CNS-STIM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: While the lung is usually adept at repairing after injury, factors that impair restoration of normal gas exchange after repetitive injury remain poorly understood. In this proposal, we will identify and study signaling pathways, including Hypoxia Inducible Factor, that inhibit normal repair mechanisms and can be targeted to improve healing after injury, thus preventing or limiting fibrosis. We believe that this work will facilitate development of new therapeutic strategies to improve outcomes in Idiopathic Pulmonary Fibrosis.

PI_NAMEs: BLACKWELL, TIMOTHY S. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acute;Acute Lung Injury;Agreement;AGTR2 gene;Alveolar;alveolar epithelium;Architecture;Area;Bleomycin;Cells;Coculture Techniques;Collagen;Data;Deposition;Development;Disease;Dose;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;Fibroblasts;Fibrosis;Functional Regeneration;Gases;Gene Expression Profile;Generations;Genetic Transcription;Genomics;healing;Human;Hypoxia Inducible Factor;hypoxia inducible factor 1;idiopathic pulmonary fibrosis;Impairment;improved;improved outcome;inhibitor;Injury;Lung;Lung Diseases;Maps;Mediator;Metaplasia;Metaplastic Epithelial Cell;Modeling;mouse model;Mus;novel;novel therapeutic intervention;Organoids;Pathway interactions;Phenotype;Pneumonia;Population;prevent;Process;Profibrotic signal;progenitor;Pulmonary Fibrosis;Recovery;repaired;Resolution;restoration;Role;Secretory Cell;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cells;Structure;Structure of parenchyma of lung;therapeutic development;Time;Tissue-Specific Gene Expression;transcriptomics;Transgenic Mice;Transitional Cell;Up-Regulation;Work

PROJECT_TITLE: Targeting dysfunctional epithelial repair in pulmonary fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]