ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Hearing Loss;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: When the cochlea is injured or infected, immune cells exit the blood vessels and enter the fluid spaces of the cochlea. How normal vascular barriers exclude these cells from the inner ear during times of health and how these barriers open to allow passage of immune cells when they are needed, is not known. We will explore how vessels control traffic of these cells, how the opening and closing of the barrier occurs, what cells in the cochlea are susceptible to virus, and what steps lead to irreversible damage and hearing loss after viral infection in the inner ear. Because viral infection in utero is a well established condition that frequently leads to hearing loss, we choose to study the effects of congenital viral infection on the blood labyrinth barrier and auditory development and determine how these two may influence each other.

PI_NAMEs: HIROSE, KEIKO  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Address;Adult;Affect;Age;Anesthesia procedures;Animals;Anti-Inflammatory Agents;Anti-viral Agents;Auditory;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Injuries;Categories;cell killing;Cells;Cessation of life;Chronic;Cochlea;congenital cytomegalovirus;critical period;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;deafness;design;Development;Disease;Effectiveness;Elements;Endothelial Cells;Ensure;Event;Exclusion;experimental group;Fetal Development;Fluorescein;Focal Infection;Functional disorder;Gene Expression;Genes;Germ;Goals;Hair Cells;Health;Hearing;hearing impairment;Homeostasis;Host Defense;Immune;Immune system;Immunity;improved;in utero;Infant;Infection;Inflammation;Inflammatory Response;Informatics;injured;Injury;inner ear development;Inner Ear Infection;Inner Hair Cells;insight;Interferon Activation;Interferon Type II;Interferons;Intervention;Labyrinth;Lead;Leukocyte Trafficking;Leukocytes;Life;Liquid substance;Mammals;Measures;Mus;Natural Immunity;Nerve Degeneration;Neuroglia;Neurons;Newborn Infant;Normal tissue morphology;Nutrient;Outcome;Oxygen;pathogen;Pathology;Perfusion;Perilymph;Permeability;Pharmaceutical Preparations;Play;Population;postsynaptic;Predisposition;presynaptic;prevent;Production;progressive hearing loss;Proteins;Role;Sampling;Sensorineural Hearing Loss;side effect;Signal Transduction;single nucleus RNA-sequencing;small molecule;spiral ganglion;Stream;success;Supporting Cell;Synapses;Techniques;Time;transcriptome sequencing;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Inner ear infection and innate immunity

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The University of Florida Gators Advancing Through Opportunities in Research for Aging and Alzheimer's Disease Education (GATORAADE) Program aims to provide comprehensive research training and didactic instruction to postbaccalaureate trainees interested in advancing our understanding of brain aging and Alzheimer's Disease and related dementias (ADRD). By addressing the behavioral, socioeconomic, biological and clinical aspects of brain aging and ADRD, the GATORAADE program will contribute to increase the pipeline of diverse researchers and healthcare professionals thus promoting a more inclusive environment and workforce in the aging and ADRD fields. In alignment with the National Institute on Aging (NIA)'s mission of fostering the development of research and clinician scientists in aging, the GATORAADE program will also empower early career researchers and pre-health professionals to gain a deeper understanding of aging and related disorders, and its impact on public health outcomes.

PI_NAMEs: ALVINA, KARINA ;MAURER, ANDREW PORTER (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: academic program;Address;Affect;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Automobile Driving;Awareness;Behavioral;Biological;Black race;Brain;career;career development;Career Mobility;Clinical;clinical training;Clinical Treatment;Clinical Trials;Cognitive;Cognitive aging;Collaborations;Communication;Competence;Course Content;Data Analyses;Dedications;Dementia;design;Development;Disease;Disparity population;Diverse Workforce;Education;Educational Curriculum;Educational workshop;Elderly;empowerment;Environment;experience;Experimental Designs;Florida;Fostering;Funding;Future;Goals;hands on research;Health;health disparity;Health Personnel;Health Professional;Healthcare;high risk;Impaired cognition;improved;Individual;Inequality;innovation;Instruction;interest;Interview;Knowledge;Laboratories;laboratory experience;Laboratory Research;Latina;Latino;Latinx population;matriculation;Measurable;member;Mentors;Mentorship;Minority;minority communities;Minority Groups;minority health disparity;Mission;National Institute on Aging;Native Americans;Neurologic;Neurosciences;Not Hispanic or Latino;older adult;Outcome;Participant;Population;Postbaccalaureate;Preparation;Process;Professional Competence;programs;Public Health;recruit;Reduce health disparities;Research;research and development;Research Personnel;Research Training;Resources;Schools;Scientist;skills;socioeconomics;Students;symposium;Training Programs;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: GATORAADE: Gators Advancing Through Opportunities in Research for Aging and Alzheimer's Disease Education

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-D (J1)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This application is for renewal of a Training Program in Diabetes and Metabolism that has been funded for the last 45 years. The Program provides postdoctoral research training for MD's, PhD's, or MD/PhD's in Diabetes and Metabolism for 6 individuals for a maximum of three years. Trainees will work in the laboratories of 20 investigators in preparation for academic careers as independent investigators.

PI_NAMEs: JENSEN, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Metabolism

PROJECT_TITLE: Diabetes and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative This application is relevant to human health because the study of gene regulation is fundamental to the biology of every cell in the human body. This application is relevant to the mission of NHGRI because it supports the development of widely-used resources for the study of gene regulation.

PI_NAMEs: HUGHES, TIMOTHY ;WEIRAUCH, MATTHEW TYSON (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Alleles;base;Binding;Bioinformatics;Biology;Cells;Chemicals;Communicable Diseases;Communities;Community Outreach;Complex;computer infrastructure;Computing Methodologies;computing resources;crosslinking and immunoprecipitation sequencing;Dangerousness;Data;data quality;Data Set;Databases;design;Development;Disease;DNA;DNA Integration;Documentation;experience;experimental study;Frequencies;functional genomics;fungus;Galaxy;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genome;genome browser;genomic data;Genomics;Goals;Health;Human;Human body;human data;human disease;Human Genetics;human pathogen;improved;in vivo;information organization;Internet;Knowledge;Life;Machine Learning;Maps;Measurement;Measures;meetings;metadata standards;Mission;Modeling;Modernization;Modification;Molecular;National Human Genome Research Institute;novel;Nucleic Acid Binding;online resource;Organism;outreach;Periodicals;Persons;Planets;Play;Positioning Attribute;Process;Protein Binding Domain;Protein Family;Proteins;Reader;Research;Resources;RNA;RNA Databases;RNA-Binding Proteins;Role;Scanning;Scheme;software infrastructure;Specificity;Structure;transcription factor;Update;user-friendly;Virus;web site;web-accessible;web-based tool

PROJECT_TITLE: CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Buck Institute's Support and Preparation for an Alzheimer's Research Career (SPARC) Program will expand and diversify the Alzheimer's Disease and Related Dementias (ADRD) research workforce. A diverse cohort of postbaccalaureates will receive hands-on research training, communication skill practice, and career development support. SPARC training will prepare participants to transition into advanced degree programs or private sector careers in AD-related disciplines.

PI_NAMEs: ANDERSEN, JULIE KAY (contact);CHIN, GREGORY MITSUO

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acceleration;Address;Advertising;age related chronic disease;Aging;aging related;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Applications Grants;Area;Awareness;Biology of Aging;Biotechnology;Black Populations;career;career development;career networking;Coffee;cohort;college;Communication;COVID-19 pandemic;Degree program;Dementia;design;Development;Discipline;Disparity;Doctor of Philosophy;education research;educational atmosphere;Ensure;Environment;Exercise;experience;Exposure to;Faculty;Feedback;Foundations;Future;Geroscience;Goals;Grant;hands on research;hands-on learning;high school;human old age (65+);Impaired cognition;Institution;interdisciplinary approach;Interdisciplinary Study;Interview;K-Series Research Career Programs;Knowledge;Latino Population;Literature;meetings;Memory Loss;Mentors;Native Hawaiian or Other Pacific Islander;next generation;Nonprofit Organizations;Occupations;Oral;outreach;Participant;peer support;Positioning Attribute;Postbaccalaureate;posters;Preparation;Private Sector;Process;programs;prospective;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;role model;Running;Scientist;Series;skill acquisition;skills;skills training;sound;Structure;student participation;Students;Study Section;Suggestion;support network;symposium;Techniques;Training;Training Activity;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;university student;Writing


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The goal of the program is to prepare exceptional future leaders in developmental biology research in both academia and industry, as well as in education. Developmental biology studies are highly relevant to human health; for example, by allowing establishment of animal models of human disease, by providing experimental systems to allow rigorous studies of genetic and genomic mechanisms in whole organisms, and by defining our understanding of stem cell biology.

PI_NAMEs: HORNE-BADOVINAC, SALLY  (contact);KRATSIOS, PASCHALIS ;PRINCE, VICTORIA E.

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Developmental Biology;Training Programs

PROJECT_TITLE: Training Program in Developmental Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Neonatal Research Training Program supports the mentored career development of pediatric physician- scientists who play a vital role in advancing knowledge related to child health. It provides a structured, intensive research experience for neonatal-perinatal post-residency fellows to obtain rigorous training in basic science, translational, or clinical research in order to advance our knowledge of developmental and newborn diseases towards the eventual implementation of novel therapeutic strategies. We aim to develop future leaders and mentors who will train the next generation of physician-scientists in the field of neonatal-perinatal medicine.

PI_NAMEs: KOUREMBANAS, STELLA  (contact);SOLA-VISNER, MARTHA C.

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TITLE: Neonatal Research Training Program


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Social Determinants of Health

ORG_CITY: ST. PAUL

ORG_NAME: ST. CATHERINE UNIVERSITY

PHR: Project Narrative The Katies for Aging Research and Equity (KARE) program advances diversity in Geroscience research by educating students within a Gerojustice framework. Our successful program is housed within a women-centered, minority-serving institution and is poised to accelerate underrepresented women and gender diverse scientists for successful aging research careers. Uniquely located within a NIA-funded T32-rich regional environment, KARE Scholars are supported throughout our innovative, multi-year program to reduce health disparities among older adults.

PI_NAMEs: CAMPBELL, KATHERINE ANN (contact);GUGGENHEIMER, JOSH ;MYERS, MARCELLA

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academic support;Acceleration;Address;age related;Aging;aging related;Award;Behavioral;Biological Factors;Biology;Black, Indigenous, People of Color;career;career development;career preparation;Clinic;Clinical;Coin;Collaborations;college;Communities;community building;Competence;Complement;Critical Thinking;design;Doctor of Philosophy;Education;education pathway;education research;Eligibility Determination;Enrollment;Ensure;Environment;Equity;Event;experience;Extramural Activities;Faculty;Funding;Future;gender diverse;Gender expansive;Generations;Gerontology;Geroscience;Goals;hallmarks of aging;Health;Health Disparities Research;health disparity;Healthcare Systems;healthy aging;higher education;Home;innovation;Institution;Investments;Journals;lectures;lens;life span;Location;Longevity;Mentors;Mentorship;Midwestern United States;Minnesota;Minor;Minority-Serving Institution;multidisciplinary;Neurosciences;older adult;Older Population;Pathway interactions;peer;Population;Population Heterogeneity;Positioning Attribute;Postbaccalaureate;prevent;Problem Solving;programs;Publications;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;response;responsible research conduct;Schedule;Scientist;Self Efficacy;Site;skills;social culture;Social Responsibility;Social support;Students;success;symposium;synergism;Time;Training;Twin Cities;undergraduate student;Universities;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (J2)]


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;HIV/AIDS

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: OVERALL PROJECT NARRATIVE The Oregon National Primate Research Center (ONPRC) is an established national resource whose primary mission is to improve human health and quality of life through exceptional nonhuman primate (NHP) research programs. The ONPRC maintains the facilities, expertise, and infrastructure required to conduct the most advanced biomedical research using NHPs in a collaborative and interdisciplinary manner that leads to novel therapies and cures for human diseases.

PI_NAMEs: BARR-GILLESPIE, PETER GORDON (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Accreditation;Address;Advanced Development;Aging;animal care;Animal Experimentation;Animal Husbandry;Animal Model;animal resource;Animals;Area;Assisted Reproductive Technology;Awareness;Behavior assessment;Behavioral;Bioinformatics;Biomedical Research;Biometry;Breeding;Businesses;Cardiovascular Diseases;Clinical;clinical care;Clinical Medicine;Clinical Research;clinically relevant;Communicable Diseases;Communities;community engagement;COVID-19 pandemic;Databases;design;Development;Disease;DNA Sequence Databases;Drug or chemical Tissue Distribution;Elderly;Electronics;elementary school;Endocrine;Ensure;Environmental Health;Faculty;Flow Cytometry;Funding;General Population;Genetic;Genetic Diseases;Genotype;germ free condition;Goals;graduate student;Grant;Health;high standard;Human;human disease;Image;Immunology;improved;Information Systems;Infrastructure;infrastructure development;Institution;interest;International;Laboratory Animal Medicine;Libraries;Logistics;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Mentors;Metabolic;Metabolic Diseases;Mission;Modeling;Modernization;Molecular;Molecular Virology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurosciences;next generation;nonhuman primate;novel therapeutics;Obesity;operation;Operative Surgical Procedures;Oregon;organizational structure;outreach;Participant;Pathology;pathology imaging;Phenotype;Population;Postdoctoral Fellow;pre-clinical research;precision medicine;Prevention;Primates;programs;Publications;Quality of life;reproductive;Reproductive Health;Research;Research Personnel;Research Support;Residencies;Resources;Rhesus;Safety;Science;science education;Scientist;Services;Students;success;surgical service;teacher;Technology;Training;Training and Education;Translational Research;translational research program;United States National Institutes of Health;Universities;Veterinarians;Work

PROJECT_TITLE: Support for National Primate Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-A (41)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: ROHNERT PARK

ORG_DEPT: BIOLOGY

ORG_NAME: SONOMA STATE UNIVERSITY

PHR: Project Narrative This study aims to uncover how somatic cells regulate proper chromosome organization during human development. Pairing of homologous chromosomes during meiosis accomplishes genetic diversity. However, during mitosis, homologous pairing in somatic cells can lead to genetic instability and tumorigenesis. The proposal explores this significant, yet largely untouched, biological paradigm of how homologous chromosomes achieve anti-pairing organization during cellular development and disease.

PI_NAMEs: HUA, LISA L (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;age-related disease;Alleles;Behavior;Biological;Biophysical Process;biophysical properties;Biophysics;Cell Cycle;cell type;Cells;cellular development;Centrosome;chromosome movement;Chromosome Pairing;Chromosome Structures;Chromosomes;Chromosomes, Human, 13-15;Data;daughter cell;Development;Disease;Dissociation;Doctor of Philosophy;Embryo;Embryonic Development;Genetic;Genetic Recombination;Genetic Variation;Genome;Genome Stability;Genomic Instability;Goals;Haploidy;high resolution imaging;Homologous Gene;Human;Human Development;human disease;Human Pathology;Image;Individual;Interphase;Ipsilateral;Malignant Epithelial Cell;Meiosis;Meiotic Recombination;Mitosis;Mitotic;Mitotic Recombination;Modeling;Mus;novel;Nuclear;nuclear division;Outcome;Outcome Study;Pathologic;Play;Positioning Attribute;predictive modeling;prevent;Property;Renal Carcinoma;response;Role;segregation;Side;Somatic Cell;Testing;Time;tumorigenesis;Umbilicus;Vascular Endothelial Cell

PROJECT_TITLE: Chromosome organization in development and adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


NIH_SPENDING_CATS: Aging

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative To improve the health of America’s aging society requires greater understanding of the complex factors affecting cognitive and physical health during aging. Since aging health is affected by biological, sociological, economic, and psychological factors which operate within a policy, epidemiological, and environmental context, multidisciplinary training is essential for future researchers in aging. This program provides developing researchers with the tools to understand the complexity of age-related health outcomes and to enrich their work by placing it in a larger context.

PI_NAMEs: AILSHIRE, JENNIFER A (contact);CRIMMINS, EILEEN M;MATHER, MARA

PROJECT_TITLE: Multidisciplinary Research Training in Gerontology

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative We propose to renew our 20-year-old UCI Training Program in Epilepsy Research. Epilepsy is the third most common brain disorder, and one that affects the young preferentially, with a tremendous loss of human potential. Surprisingly, Epilepsy is relatively understudied and underfunded; thus, there is a major unmet need to encourage and train the new generation of the Epilepsy Investigator Workforce. Our program has strived and succeeded in preparing a diverse groups of students for their Research Career in Epilepsy and Neuroscience Research. We hope to continue this effort and educate the next generation of diverse, outstanding trainees and provide them with state-of-the-art approaches to the understanding of Epilepsy and its co-morbidities, as well as professional skills for their career development.

PI_NAMEs: BARAM, TALLIE Z.  (contact);HUNT, ROBERT F

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Epilepsy Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Increasing the diversity of the biomedical PhD workforce will result in more diverse perspectives on health issues and increase the impact and pace of scientific discovery. Through mentoring, financial support, and professional skill development, the MARC program at UCLA seeks to increase the number of undergraduates from underrepresented backgrounds who enroll in biomedical PhD programs at highly selective institutions and ultimately become leaders in biomedical disciplines.

PI_NAMEs: MCEVOY, MEGAN M (contact);POE, GINA R

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Biological Sciences;California;career awareness;CCL7 gene;Communities;community building;design;Development;Doctor of Philosophy;Enrollment;Event;evidence base;experience;Faculty;Feedback;Funding;Goals;Human;Individual;Institution;Instruction;Los Angeles;meetings;Mentors;next generation;Play;programs;recruit;Reproducibility;Research;Research Methodology;Research Training;responsible research conduct;Role;Science;science and society;Scientist;skills;social;Structure;Students;symposium;Training;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: MARC at the University of California, Los Angeles

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Pediatric

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: NARRATIVE The Children’s Surgery Methodology And Research Training (C-SMART) Program will develop the next generation of surgical scientists focused on pediatric-specific populations and diseases. The Program will provide a robust 2-year surgical research training experience curated by highly accomplished mentorship from researchers and clinicians. The C-SMART Program will be a national leader in increasing the pipeline of diverse and qualified pediatric surgeons and PhD scientists who will have successful research careers, mentor future generations of trainees, and make significant advances in the care of children.

PI_NAMEs: RAVAL, MEHUL V. (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Child;Methodology;Operative Surgical Procedures;Research Training


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE We propose to survey health care workers and the general public on vaccine-related issues by recruiting through opt-in, online survey panels and using computer-assisted self-interviewing (CASI) instruments. We argue that our proposed methods provide data more quickly, affordably, and flexibly than the current method.

PI_NAMEs: GIDENGIL, COURTNEY ;PARKER, ANDREW ;SCHERER, AARON MICHAEL (contact)

PROJECT_TITLE: RFA-IP20-005: Informing Immunization Strategies Through Rapid, Repeated Computer-Assisted Self-Interviewing Instruments and Online Panels of Physicians and the Public


ADMINISTERING_IC: DD

IC_NAME: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative This study will shed light on a wide variety of genetic, prenatal, early-life and family factors that influence the risk for autism spectrum disorder (ASD) and on differences and similarities in the behaviors, abilities, and health of preschoolers with ASD. It will also provide insights into the experiences of adolescents with ASD as they mature. By helping to explain the causes of ASD and how ASD affects children, youth and young adults, this project will contribute to efforts to reduce the risk of ASD and improve the outcomes of affected children.

PI_NAMEs: CONSTANTINO, JOHN N.;FITZGERALD, ROBERT  (contact)

PROGRAM_OFFICER_NAME: OGUNFUYI, SHAKIRATU BIOLA

PROJECT_TITLE: Missouri Study to Explore Early Development (SEED) Follow-Up


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Microbiome;Ovarian Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Ovarian cancer (OC) is the most lethal of gynecologic cancers, with a 5-year survival rate of 48%. There is a significant survival disadvantage in Black women. Given this disparity, it is crucial to gain an understanding of the biological impact of social and socioeconomic differences between Black and White women with OC.

PI_NAMEs: DEVEAUX, APRIL  (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: 16S ribosomal RNA sequencing;access disparities;acute stress;Address;Advanced Development;advanced disease;Anti-Inflammatory Agents;Basic Science;beta diversity;Bioinformatics;Biological;Biometry;Black race;black women;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer initiation;Cancer Patient;cancer risk;cancer survival;Carcinoma;Cardiovascular Diseases;Chronic;Clinical;cohort;Communities;Data;Data Analyses;Data Collection;Data Reporting;Diabetes Mellitus;Diagnosis;Dimensions;Disadvantaged;Disparity;disparity reduction;Drug usage;dysbiosis;Environmental Risk Factor;epidemiology study;experience;follow-up;Funding;Future;Geographic Factor;Grant;Guidelines;Health;health care availability;Health Services Accessibility;high risk;High-Risk Cancer;Histology;Incidence;Infection;Inflammation;Intervention;Investigation;Link;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Measures;Mediating;Mental Depression;microbial;microbial community;microbiome;Molecular Epidemiology;mortality;mortality risk;Newly Diagnosed;Non-Steroidal Anti-Inflammatory Agents;Obesity;Outcome;Ovarian;Pathway interactions;Patient Self-Report;perceived discrimination;Pharmaceutical Preparations;PhenX Toolkit;Play;Psychosocial Stress;Public Health;Publishing;racial difference;racial discrimination;racial disparity;Recommendation;reproductive tract;Research;Risk;Risk Factors;Sampling;Screening for Ovarian Cancer;Secondary to;Serous;social;social determinants;social health determinants;Social Interaction;Socioeconomic Factors;socioeconomics;Stage at Diagnosis;survival disparity;Survival Rate;Swab;Testing;Therapeutic;Therapeutic Intervention;Training;Treatment/Psychosocial Effects;tumor progression;tumorigenesis;United States;United States National Institutes of Health;Vagina;vaginal microbiome;White Women;Woman

PROJECT_TITLE: Experiences of Discrimination, Dysbiosis, and Racial Disparities in Ovarian Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Many types of solid tumors, including anaplastic thyroid cancer (ATC), are treated with external beam radiation with cytotoxic chemotherapy to improve cure rates and/or tumor control. BRAF activating mutations are the single most common oncogenic mutation in ATC (occurring in 30-40% of tumors), and our preliminary data supports that BRAF mutations promote therapeutic resistance to radiation and other genotoxic therapies. Developing a better understanding of this mechanism as well as developing more tumor-selective approaches to improve sensitivity to genotoxic therapies in BRAF mutant and BRAF wild-type ATC will improve our ability to control and cure this difficult cancer.

PI_NAMEs: WILLIAMS, TERENCE MARQUES (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;anaplastic thyroid cancer;Apoptosis;Biological Markers;Biological Response Modifier Therapy;biomarker identification;Blood specimen;BRAF gene;cancer cell;Cell Cycle Checkpoint;Cell Survival;cell type;Cells;Cessation of life;Chemoresistance;chemotherapy;Clinical;combinatorial;Cytotoxic Chemotherapy;Data;Dependence;disorder control;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA-dependent protein kinase;Double Strand Break Repair;Drug Kinetics;Esophagus;Excision;External Beam Radiation Therapy;FDA approved;Fostering;Frequencies;Future;G2/M Checkpoint Pathway;Genes;genomic profiling;Genomics;genotoxicity;Immunocompetent;Impairment;improved;improved outcome;In Vitro;in vivo;inhibitor;Institution;kinase inhibitor;Malignant neoplasm of thyroid;Malignant Neoplasms;MAP2K1 gene;Maximum Tolerated Dose;Mediating;MEK inhibition;MEKs;Molecular;molecular subtypes;Morbidity - disease rate;mortality;mouse model;mutant;Mutate;Mutation;neoplastic cell;Nonhomologous DNA End Joining;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Oncogenes;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;phase I trial;phase II trial;Phosphotransferases;Play;pre-clinical;Prognosis;Radiation;radiation resistance;Radiosensitization;RAS inhibition;Ras/Raf;Recurrence;Recurrent disease;Regional Disease;repaired;research clinical testing;Resistance;response;response biomarker;Role;Safety;sensor;Signal Pathway;Signal Transduction;small molecule inhibitor;Solid Neoplasm;standard of care;Testing;therapeutic target;therapy resistant;Tissue Sample;Toxic effect;TP53 gene;Treatment Failure;tumor;Up-Regulation;uptake

PROJECT_TITLE: Developing BRAF mutant and BRAF wild-type selective strategies for radiosensitization in Anaplastic Thyroid Cancer

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation;Social Determinants of Health

ORG_CITY: Atlanta

ORG_NAME: MAPHABIT, INC.

ORG_STATE: GA

PHR: PROJECT NARRATIVE MapHabit’s proposal is focused on the development of science-based, innovative assistive technology for people living with Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD). The technology objective is to help individuals maintain their independence and autonomy longer and reduce the burden of AD/ADRD caregiving by using visual mapping that cues behavior. These goals reflect the nation’s public health goals of reducing the burden of AD/ADRD on individuals, their families, and society at large. LiveWell's science-based, innovative caregiver training program (CTP) offers educational and self-care training to caregivers to reduce their burden of AD/ADRD caregiving. The integration of the MapHabit System (MHS) with the CTP will be the first app-based, personalized caregiving product to integrate caregiver training that focuses on self-care with an evidence-based visual mapping interactive care management platform. These combined behavioral tools will translate to improved independence, autonomy, and enhanced quality of life for individuals under care with AD/ADRD and their circle of support.

PI_NAMEs: GOLDEN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Behavioral;Brain region;Caregiver Burden;caregiver education;caregiver quality of life;Caregiver support;Caregivers;caregiving;Caring;Client satisfaction;Cognition;cognitive testing;Communities;community building;cost;Cues;dashboard;Data;dementia caregiving;design;Development;Education;Effectiveness;Emotional;evidence base;experience;Family;functional status;Goals;Habits;Health care facility;health goals;Home;Hospitals;improved;Individual;Information Networks;innovation;Knowledge;Learning;Legal patent;Managed Care;Marketing;Measurable;Measures;memory care;mHealth;Motivation;Neurosciences;Occupations;Outcome;Patient Care;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Personal Satisfaction;Persons;Phase;Provider;Public Health;Quality of Care;Quality of life;Role;Science;Self Care;Self Perception;Self-Help Devices;skills;smart device;social;Social Network;Social support;Societies;Standardization;Stress;Support System;System;Technology;tool;Training;Training Programs;Translating;usability;visual map

PROJECT_TITLE: An assistive-technology based Caregiver Training Program (CTP) to enhance caregiver effectiveness, well-being, and quality of life, which will improve overall care for individuals living with AD/ADRD.


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Prominent successes of the NIH BRAIN Initiative to date include the identification of many new types of neurons, but to understand how these cell-types work together in the live brain it will be crucial to have techniques that can record the coordinated voltage dynamics of multiple classes of identified neurons simultaneously. To create such techniques, we will engineer four novel fluorescent indicators of neuronal trans-membrane voltage and three new optical instruments tailored to use these indicators to image either the spiking or oscillatory voltage dynamics of up to four neuron-types concurrently in the brains of awake behaving animals. These innovations will reveal how multiple neuron-types act concertedly at the millisecond-scale to support information-processing and shape a wide range of neurophysiologic states.

PI_NAMEs: SCHNITZER, MARK J (contact);VASAN, GANESH

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: absorption;Action Potentials;Address;Amino Acid Sequence;Animal Behavior;Animals;Area;awake;Brain;Brain imaging;BRAIN initiative;brain shape;Categories;cell type;Cells;Cephalic;Chronic;Color;Complement;Computer software;Data;Deposition;design;Devices;Disease;Dorsal;Educational workshop;Electrodes;Engineering;Feedback;Fiber Optics;Fluorescence Resonance Energy Transfer;fly;Genetic;genetic signature;Head;Health;high throughput screening;Image;Imaging Device;imaging facilities;imaging modality;imaging study;Imaging Techniques;improved;Individual;information processing;innovation;instrument;Intelligence;invention;Kinetics;Knowledge;Label;Laboratories;Learning;Licensing;Light;Machine Learning;machine learning framework;machine learning method;Mammals;Membrane;Membrane Potentials;Methods;microendoscopy;Microscope;millisecond;Molecular;Monitor;Mus;mutant;neocortical;neural;neural circuit;neuroimaging;Neurons;neurophysiology;new technology;novel;novel strategies;Opsin;Optical Instrument;Optics;optogenetics;Outcome;Pattern;Performance;Population;Preparation;Proteins;public repository;Publishing;R24;Research;Resolution;Resource Sharing;response;Rodent;Science;Scientist;screening;sensor;Shapes;Slice;Specificity;Speed;success;Surface;synergism;Techniques;Testing;Time;tool;Training;Transgenic Organisms;United States National Institutes of Health;Universities;Validation;Variant;Viral Vector;Visit;voltage;Work

PROJECT_TITLE: Multi-color optical voltage imaging of neural activity in behaving animals


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Toxoplasma gondii, an important food pathogen, causes severe economic and human toll world wide, including in the United States. The goal of this proposal is to determine the factors that allow the development and maintenance of protective immunity against the pathogen so that therapeutic agents in the susceptible hosts can be developed.

PI_NAMEs: KHAN, IMTIAZ AHMED (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Ablation;Acquired Immunodeficiency Syndrome;Agonist;Antigens;Binding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cell Physiology;Cells;Central Nervous System Infections;Cerebral Toxoplasmosis;Chromatin;Chronic;chronic infection;Communicable Diseases;cytotoxic;Data;Development;Down-Regulation;Economics;Encephalitis;Epigenetic Process;exhaustion;Exhibits;experimental study;Failure;Food;Functional disorder;Goals;HIV Infections;Human;Immunity;Immunocompromised Host;Individual;Infection;insight;Laboratories;latent infection;Life;Link;Maintenance;Malignant Neoplasms;Mediating;Memory;Methylation;mouse model;Mus;OX40;Parasites;pathogen;Patients;Play;Population;Predisposition;prevent;programs;promoter;Publishing;reactivation from latency;receptor;Receptor Gene;Recovery;Reporting;response;restoration;Role;Signal Transduction;Signaling Molecule;Site;T cell response;Therapeutic;Therapeutic Agents;Toxoplasma;Toxoplasma gondii;toxoplasmic encephalitis;Toxoplasmosis;transcription factor;United States;Up-Regulation

PROJECT_TITLE: CD4 dysfunction and cerebral toxoplasmosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative As the pace at which biomedical research advances accelerates, there is a greater need than ever for physicians and veterinarians who are trained investigators, working at the intersection between medicine and science to develop new understanding of human and animal biology and new approaches to the treatment and management of disease. The goal of the MD/PhD and VMD/PhD programs at the University of Pennsylvania is to prepare a diverse group of outstanding individuals to become the leaders of biomedical human and veterinary research, as well as teachers, clinicians, scholars, leaders, role models and mentors.

PI_NAMEs: ATCHISON, MICHAEL LEE;BRASS, LAWRENCE F (contact);KOHLI, RAHUL MANU

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Genetics

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE The high rate of mutations in human mitochondrial DNA is a major cause of inherited and age-related diseases, but the mechanisms responsible for these elevated mutation rates are still uncertain and controversial. The proposed research will advance our understanding of what causes variation in mitochondrial mutation rates by examining differences in mechanisms of mitochondrial DNA repair across diverse eukaryotic model systems.

PI_NAMEs: SLOAN, DANIEL BENJAMIN (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: age-related disease;Animal Model;base;Biological Models;Characteristics;de novo mutation;DNA Damage;DNA Repair;DNA Sequence;Eukaryota;Event;Exhibits;Frequencies;Future;Gene Family;Genome;Human;human model;Inherited;innovation;Investigation;Length;Life;Maps;member;Metabolic;Mismatch Repair;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mutation;Nature;novel;Nucleotide Excision Repair;Nucleotides;Oligonucleotides;Organelles;Oxidative Phosphorylation;Pathway interactions;Plants;Point Mutation;Positioning Attribute;programs;recombinational repair;repaired;Research;Resolution;Site;Technology;Testing;Trees;Ultraviolet Rays;Uncertainty;Variant;Virus;Work

PROJECT_TITLE: Mechanisms of mitochondrial mutation rate variation across eukaryotes

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Mental Health;Neurosciences;Pediatric

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Social interactions with peers are the building blocks of adolescent social development and puberty is a developmental period during which processes underlying social interactions, such as social attention and mentalizing, are in flux. Integration of social attention and mentalizing during puberty may facilitate social reorientation, preparing adolescents for adult life and solidifying or disrupting risk for social anxiety. The proposed project will take a naturalistic approach to examine cross-sectional and longitudinal relations between social attention, mentalizing, puberty and social anxiety.

PI_NAMEs: VALLORANI, ALICIA  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 12 year old;2 year old;Address;Adolescence;Adolescent;Adult;Age;Attention;Behavior;Behavioral;Behavioral inhibition;Biological Process;boys;Brain;career;Career Choice;Caregivers;Child;Code;Data;Data Analyses;Data Set;design;Development;Diagnosis;Disease;Emotional;Emotions;Event;Exhibits;experience;Face;Fellowship;Foundations;Fright;Functional Magnetic Resonance Imaging;Future;girls;Goals;Grant;Health;Individual;Influentials;Language;Life;Link;Measures;Mediation;mentalization;Methodology;Methods;Modeling;movie;neural;neurodevelopment;Neurosciences;Participant;Patient Self-Report;Pattern;peer;Play;Preparation;Process;Process Assessment;programs;Psychopathology;pubertal timing;Puberty;Research;Risk;Risk Factors;Role;Sampling;sex as a biological variable;Sex Differences;social;social anxiety;social attention;Social Behavior;Social Change;Social Development;social influence;Social Interaction;social learning;Social Processes;Stimulus;Structure;Temperament;theories;Training;United States National Institutes of Health;visual tracking;Work

PROJECT_TITLE: Social Attention and Mentalizing During Puberty and Risk for Social Anxiety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life. Promoting neuroplasticity may support upper limb recovery after SCI. Repetitive exposure to acute intermittent hypoxia (rAIH) combined with motor training promotes recovery of motor function after SCI; however, the overall effects of rAIH/training are limited. We will use an adult rat model of long-term contusive cSCI to study novel approaches to enhance the effect of rAIH/training on forelimb function and study the neuronal substrate underlying the effects. The findings will be used to direct the development of more effective rAIH/training approaches for people with contusive, functionally incomplete, cSCI. Because deficits in upper limb function are a major problem after stroke, amyotrophic lateral sclerosis, multiple sclerosis, and other motor disorders, our work may also be relevant for patients with other types of CNS lesions.

PI_NAMEs: CASELLA, GIZELDA T.B.;OUDEGA, MARTIN  (contact);PEREZ, MONICA A

PROJECT_TERMS: Acute;Adult;Agonist;Amyotrophic Lateral Sclerosis;Anatomy;Animals;arm function;Bilateral;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;clinical application;Contusions;Corticospinal Tracts;Cycloserine;Data;Development;Dose;Electrophysiology (science);experimental study;Exposure to;Forelimb;Frequencies;Goals;grasp;Growth Associated Protein 43;Hand;Hand functions;hand rehabilitation;Human;Hypoxia;Imaging Techniques;immunocytochemistry;Impairment;improved;Individual;Intervention;Knowledge;Lesion;Life;Location;Lower Extremity;Measurement;Mediating;minimally invasive;Modeling;Motor;motor disorder;motor function recovery;Motor Neurons;motor recovery;Multiple Sclerosis;Muscle function;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neuronal Plasticity;Neurons;novel strategies;Patients;Persons;Pharmaceutical Preparations;post stroke;Protocols documentation;Quality of life;Rattus;Recovery;Recovery of Function;Recovery Support;Research;Spinal Cord Contusions;Spinal cord damage;spinal cord repair;Spinal Injuries;Synapses;Synaptic plasticity;Testing;Training;Upper Extremity;Upper limb movement;Veterans;Work

PROJECT_TITLE: Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Exposure to drugs of abuse, such as alcohol, induces plasticity in the brain and creates persistent drug-related memories that contribute to alcohol dependence. This project seeks to characterize transcriptional alterations in AUD, notably pathways related to the extracellular matrix (ECM) in human subjects and to test how genetically modifying a microglial ECM protease signaling pathway may alter alcohol-related memories. Results from these studies will inform more effective treatments for and/or optimize current treatment paradigms for AUD.

PI_NAMEs: VALERI, JAKE RYAN (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acute;addiction;Adult;Affect;alcohol comorbidity;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol memory;alcohol reward;alcohol use disorder;Alcohols;Anabolism;Area;Astrocytes;Autopsy;Brain;Brightfield Microscopy;Cells;Chondroitin Sulfate Proteoglycan;cohort;comorbidity;Complex;conditioned place preference;Confocal Microscopy;Corpus striatum structure;Cue-induced relapse;cytokine;Data;Dependence;design;Development;Drug Addiction;drug of abuse;effective therapy;Enzymes;Excitatory Synapse;experience;experimental study;Exposure to;Extracellular Matrix;Extracellular Matrix Degradation;fear memory;Gene Expression Profile;Gene Expression Profiling;Gene Modified;Glycoproteins;high reward;Hippocampus;Human;human subject;Individual;Interleukins;Interneurons;Intoxication;Knock-out;Knockout Mice;Label;Literature;Maintenance;Major Depressive Disorder;Matrix Metalloproteinases;Measures;Mediating;Memory;memory acquisition;memory consolidation;Methods;Microglia;MMP9 gene;Modeling;Molecular;Mood Disorders;mRNA Expression;Mus;Neuroglia;Neurons;neurotransmission;next generation sequencing;novel strategies;Parvalbumins;Pathology;Pathway interactions;Peptide Hydrolases;Persons;Pharmaceutical Preparations;pharmacologic;Phase;postsynaptic;pre-clinical;preclinical study;preference;Prefrontal Cortex;presynaptic;Prevalence;prevent;Process;Protease Inhibitor;protein expression;Public Health;receptor;Recovery;Regulation;Regulatory Pathway;Rewards;Rodent;Rodent Model;Role;Sampling;Signal Pathway;Signal Transduction;Substance Use Disorder;Synapses;Techniques;Testing;Therapeutic;therapeutic development;Tissue Sample;Tissues;Transcription Alteration;transcriptome sequencing;Transgenic Organisms;Work

PROJECT_TITLE: The Role of the Extracellular Matrix in Alcohol Use Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Emotional experience shows well documented shifts across adulthood. Emotions impact all aspects of health and well-being ranging from physical health to mental health to adaptive decision-making and social relationships. Consequently, a better understanding of the neurobiological mechanisms underlying maturational shifts in emotional experience can support scientists, practitioners and policymakers working on the prevention and treatment of health disorders (e.g., geriatric depression, cardiovascular disease, dementia) and policies to support our globe’s growing population of older adults.

PI_NAMEs: FELDMAN, MALLORY JEAN (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Affective;Affective Symptoms;age difference;age related;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Award;bodily sensation;Brain;Brain scan;Cardiovascular Diseases;Cardiovascular system;Central Nervous System;Cognitive aging;cognitive process;Cohort Studies;Communities;comparative efficacy;Data;Data Analytics;Decision Making;Dementia;Development;Disease;emotion regulation;Emotional;Emotional disorder;emotional experience;Emotions;Equation;experience;falls;Functional Magnetic Resonance Imaging;geriatric depression;Grant;graph learning;graph theory;Health;Health Promotion;Healthcare;Informal Social Control;Interoception;investigator training;Journals;Knowledge;late life;Learning;lectures;Life;life span;Link;Measurement;Measures;Memory;Mental Health;Mentorship;Methodology;Methods;Modeling;Motivation;multimodality;neurobiological mechanism;Neurobiology;novel;older adult;Older Population;Participant;Patient Self-Report;Peer Review;Peripheral;Peripheral Nervous System;Personal Satisfaction;Persons;physical conditioning;Physiological;Physiology;Policies;Policy Maker;Population;positive emotional state;Postdoctoral Fellow;Prevention;Process;Productivity;Regulation;Reporting;Research;Sampling;Scientific Advances and Accomplishments;Scientist;skill acquisition;social relationships;Structure;Supervision;support network;Support System;symposium;System;Techniques;Testing;Training;ultra high resolution;United States National Institutes of Health;young adult

PROJECT_TITLE: Age-related differences in neurobiological systems supporting emotion


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Here we study the genome organization mechanisms by which IKAROS, a lymphoid- lineage transcription regulator, supports B cell differentiation and antibody formation. Elucidating these fundamental mechanisms that support development of a diverse B cell repertoire and safeguard against lineage infidelity will provide new approaches to fight high- risk B cell lymphoblastic leukemias.

PI_NAMEs: GEORGOPOULOS, KATIA  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Antibody Formation;Architecture;B cell differentiation;B cell repertoire;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Behavior;Binding;Binding Proteins;Binding Sites;Biochemical;Bioinformatics;Cell Nucleus;cell type;Cells;Chromatin;chromatin modification;Chromatin Structure;cohesin;comparative;Complex;Confined Spaces;Coupled;Data;derepression;Development;Dimerization;Disease;DNA;DNA cassette;empowerment;Engineering;Enhancers;Epithelial Cells;Epithelium;Event;experimental study;fighting;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Goals;high risk;Higher Order Chromatin Structure;histone modification;Histones;IgK;Ikaros protein;in vitro Assay;in vivo;Knowledge;loss of function;Lymphoid;Malignant - descriptor;Mediating;Modeling;Mus;mutant;Mutation;neural;Neurons;novel;novel strategies;Nuclear;NuRD complex;Organization administrative structures;Pathogenesis;Patients;Phase;Process;promoter;Property;Proteins;Regulation;Repression;Resistance;Role;Sampling;segregation;Site;Specific qualifier value;Structure;System;Tertiary Protein Structure;Testing;Tissue Differentiation;Tissues;tool;Work

PROJECT_TITLE: Ikaros regulation: Study on hemolymphopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

ORG_STATE: NY

PHR: Project Narrative We propose to implement and rigorously evaluate a novel ‘data-to-suppression’ (D2S) intervention with Ryan White HIV/AIDS Program Part A (RWPA) support-service programs, to address a viral suppression (VS) deficit among RWPA clients in HIV care. While data-to-care (D2C) efforts pursue data sharing and linkages with medical providers, our premise is that support-service (particularly behavioral health and housing) program staff are best positioned to address major barriers to antiretroviral adherence, once they have the information needed to triage those who struggle to maintain VS. Surveillance data sharing by health departments with their community-based Ryan White programs may be especially critical to fill communication gaps between clinical and support-service providers as ‘telehealth’ becomes more prevalent in response to the COVID-19 pandemic.

PI_NAMEs: IRVINE, MARY KATHRYN;NASH, DENIS  (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;barrier to care;Behavioral;behavioral health;Black Populations;Black race;care coordination;Caring;Characteristics;Cities;Client;Clinical;Communication;Communities;Continuity of Patient Care;County;COVID-19;COVID-19 burden;COVID-19 pandemic;Data;Data Collection;Data Linkages;data resource;data sharing;design;Diagnosis;disparity reduction;effectiveness evaluation;Enrollment;Epidemic;epidemic preparedness;evidence base;Evidence based intervention;experimental study;Factor Analysis;Focus Groups;follow-up;Funding;Future;Goals;Government;Health;health disparity;Health system;HIV;HIV Infections;HIV/AIDS;Housing;hybrid type 1 study;hybrid type 1 trial;Hybrids;implementation measures;implementation outcomes;implementation research;implementation science;improved;Income;Intervention;intervention delivery;intervention effect;Interview;Latinx;Latinx population;Left;Light;Link;Low income;Low Income Population;Maintenance;Measures;Medicaid;Medical;meetings;Methods;Modeling;Modification;Monitor;multiple datasets;Neighborhoods;New York City;novel;Outcome;outcome disparities;outreach;Participant;patient navigator;Persons;Positioning Attribute;post-COVID-19;Poverty;preference;programs;Provider;psychosocial;Psychosocial Influences;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Reporting;Research;research to practice;Resources;response;Route;safety net;scale up;service delivery;service programs;service providers;Service setting;Services;Shapes;Site;social;stem;success;surveillance data;telehealth;Testing;therapy adherence;Time;Translations;treatment arm;Triage;trial design;Uninsured;United States Health Resources and Services Administration;uptake;Viral

PROJECT_TITLE: Strengthening the Safety Net: Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Alzheimer's disease (AD) is an escalating major health concern in the United States. The proposed research will use cutting-edge neuroscience techniques to map vulnerable cell types and neural connectivity changes using mouse models of aging and AD. Our research meets multiple major goals of RFA-AG-22-008 and is expected to have high impact by providing critical reference information for molecular and neural circuit studies of multiple established and new AD models for the large AD research community.

PI_NAMEs: GREEN, KIM ;MUKAMEL, ERAN A;XU, WEI ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Age;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Anatomy;Atlases;Behavioral;Brain;BRAIN initiative;Brain Mapping;Brain region;cell type;Cells;Code;Cognitive deficits;Communities;computational pipelines;connectome;connectome data;Data;Data Set;data sharing;Defect;Dementia;Development;diagnostic tool;Disease Progression;Disease Resistance;Elements;entorhinal cortex;Environment;epigenomics;excitatory neuron;experimental study;Fluorescent in Situ Hybridization;Funding;Gene Expression;Gene Modified;Goals;Health;Hippocampal Formation;Hippocampus;Human;Image;Impairment;improved;Institution;Knock-in Mouse;Late Onset Alzheimer Disease;Lead;Maps;Missense Mutation;model development;Modeling;Molecular;Molecular Genetics;mouse model;Mus;Mutation;Nerve Degeneration;neural;neural circuit;neural network;Neurons;neuropathology;Neurosciences;neurotropic virus;next generation;novel;novel therapeutic intervention;older adult;Output;Pathology;Patients;Predisposition;Property;rabies viral tracing;Research;Research Personnel;Resolution;Resource Sharing;Resources;response;Risk;RNA;Science;Standardization;success;Synapses;System;Techniques;Technology;Tissues;tool;Toxic effect;transcriptomics;TREM2 gene;United States;Variant;Viral;virus genetics;Work;Yellow fever virus

PROJECT_TITLE: Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

PHR: Project Narrative: Idiopathic pulmonary fibrosis (IPF) is a progressive and deadly fibrotic disease of the lung, where early microscopic diagnosis and assessment of disease progression are essential to determine which therapy may be the most effective for patients and whether individual patients are responding to those therapies. Unfortunately, computed tomography cannot detect early IPF or microscopic changes over time, and surgical lung biopsy to obtain tissue for microscopy has high risks of adverse events and even death. The goal of this proposal is to validate a low-risk, minimally-invasive optical bronchoscopy tool for early microscopic IPF diagnosis and monitoring of therapy response in order to offer patients the most effective treatment for their specific diagnosis and monitor treatment efficacy early on in the disease, which will improve patient outcomes and survival.

PI_NAMEs: HARIRI, LIDA P (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: accurate diagnosis;adverse event risk;Affect;Anatomy;antifibrotic treatment;Biopsy;Blinded;Bronchoscopy;Catheters;Cessation of life;Clinical;Clinical Research;Correlative Study;Data;Databases;Death Rate;Diagnosis;Diagnostic;Disease;Disease Progression;Early Diagnosis;Early treatment;effective therapy;efficacy evaluation;Elements;FDA approved;feature detection;Fibrosis;fibrotic interstitial lung disease;fibrotic lung disease;Goals;healthcare burden;High Resolution Computed Tomography;high risk;Histologic;Histology;Hospitalization;Hospitals;idiopathic pulmonary fibrosis;Image;imaging modality;Immunosuppression;improved;in vivo;Individual;individual patient;Interstitial Lung Diseases;Libraries;Location;Lung;Lung Diseases;lung volume;Maps;Measures;Methods;Microscopic;Microscopy;minimally invasive;Monitor;Morbidity - disease rate;mortality risk;Multicenter Studies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;optimal treatments;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Peripheral;Persons;Pilot Projects;prevent;Prognosis;prospective;pulmonary function;Pulmonary function tests;Reader;Resolution;Rhode Island;Risk;Sampling;Sensitivity and Specificity;Site;socioeconomics;Structure;Structure of parenchyma of lung;Survival Rate;Testing;Thinness;Three-Dimensional Imaging;three-dimensional visualization;Time;Tissues;tool;Translating;Treatment Efficacy;treatment response;Usual Interstitial Pneumonia;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: In vivo endobronchial OCT for IPF diagnosis and therapy response assessment

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is an incurable, disabling, and often fatal disease characterized by the accumulation of myofibroblasts predominantly in the peripheral areas of the lung. Identifying Sox9-driven gene networks involved in fibroblast activation will validate the pathological role of Sox9 in IPF.

PI_NAMEs: MADALA, SATISH K (contact)

PROJECT_TERMS: Adult;American;Apoptosis;Apoptotic;Area;Attenuated;BCL1 Oncogene;BCL2L1 gene;Biochemical;Biological Assay;Bleomycin;Cartilage;Cell Separation;Cell Survival;Cells;chronic liver disease;Cicatrix;Cirrhosis;Co-Immunoprecipitations;Collagen;Complex;Coupled;crosslink;Data;Deposition;Development;Diagnosis;Disabling;Disease;Distal;effective therapy;epithelial stem cell;experimental study;Extracellular Matrix;Family;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Future;Gene Expression;Gene Expression Profiling;gene network;Generations;Genes;Genetic Transcription;Goals;Growth Factor;HMG-Box Domains;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;in vivo Model;innovation;insight;Knowledge;Laboratories;Learning;Lesion;LOXL2 gene;Luciferases;Lung;lung development;Lung Diseases;lung lesion;Maintenance;Medical;member;Mesenchymal;Methods;migration;Modeling;Molecular;Morphogenesis;mouse model;multidisciplinary;Mus;Myofibroblast;Nephroblastoma;novel;Organ;overexpression;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Patients;Peripheral;Prevention;Process;Production;programs;promoter;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Pathology;Regulation;Regulator Genes;Research;Resolution;Respiratory Failure;Role;selective expression;Severities;Testing;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Transforming Growth Factor alpha;Transforming Growth Factor beta;Transgenic Mice;translational study;treatment strategy;Up-Regulation

PROJECT_TITLE: Sox9 Regulation of Fibroblast Activation and Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Deciding whether to explore a new opportunity or exploit what already has been learned is a fundamental component of behavioral flexibility. Unbalanced exploration or exploitation can have dramatic consequences on well-being and quality of life, however, explore-exploit decision making is understudied in psychiatry because the neural mechanisms underlying it are not well understood. The research in this grant will uncover the neural mechanisms underlying explore-exploit decision making and determine if different cortical and subcortical circuits are engaged when the motivation to explore novel opportunities is driven by a desire to maximize gains or minimize losses.

PI_NAMEs: COSTA, VINCENT D (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Amygdaloid structure;Animals;Anterior;arm;Attenuated;Behavior;Behavioral;Brain;Brain region;Code;cognitive control;Computer Models;Conditioned Reflex;Data;Decision Making;Desire for food;Disease;Equilibrium;experience;Feedback;flexibility;Genetic;Goals;Grant;Human;Lead;Learning;Lesion;Location;Macaca mulatta;Mental disorders;Modeling;Monkeys;Motivation;neural;neural circuit;neuromechanism;Neurons;novel;Nucleus Accumbens;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Population;Prefrontal Cortex;Primates;Process;Psychiatry;Quality of life;Research;Rewards;Signal Transduction;Testing;Time;Training;transmission process;Uncertainty;willingness

PROJECT_TITLE: Neurocomputational mechanisms of explore-exploit decision making in prefrontal and motivational neural circuits

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;HIV/AIDS;Infectious Diseases;Nanotechnology;Natural Products;Neurodegenerative;Neurosciences;Prevention;Substance Misuse

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative: With the use of cART, even after the complete suppression of viral load in the peripheral system, active/latent HIV infection, neuroinflammation and associated neurocognitive impairments could not be eliminated in cannabinoid abusers due to the continuous production of HIV-1 Tat protein and inability of the drugs to cross the blood-brain barrier. In this study, we are using a novel gene-editing CRISPR/Cas9 technology targeting HIV-1 Tat gene in microglia in combination with a recently discovered (by Dr. Alexandros Makriyannis, co-PI of the grant) stable endocannabinoid analog AMG315 in both in vitro and in vivo iTat mice model employing our patented (US 20130317279 A1 and WO2014074584 A1) nanotechnology drug delivery approach. Successful delivery of the nanoformulation across the BBB will have a translational significance in the prevention of neurocognitive impairments in HIV positive cannabinoid-abusing patients.

PI_NAMEs: LAKSHMANA, MADEPALLI KRISHNAPPA (contact);MAKRIYANNIS, ALEXANDROS

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Affinity;Analgesics;analog;anandamide;Animal Model;Anti-Inflammatory Agents;antiretroviral therapy;astrogliosis;Attenuated;Behavioral;Binding;Biological Models;blood-brain barrier crossing;Brain;cannabinoid administration;Cannabinoids;Cells;Charge;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;controlled release;CRISPR/Cas technology;Development;Disease;DNA;Doxycycline;Drug Delivery Systems;drug of abuse;Drug Targeting;Electromagnetics;Electrostatics;Encapsulated;Endocannabinoids;endogenous cannabinoid system;gene editing technology;Genes;Genetic Transcription;Genome;Grant;Guide RNA;HIV;HIV Genome;HIV Infections;HIV Seropositivity;HIV-1;HIV-associated neurocognitive disorder;Impairment;improved;In Vitro;in vivo;Induced Neurons;Infection;Inflammasome;Inflammation;latent infection;Legal patent;Ligands;Liposomes;magnetic field;marijuana use;Mediating;Medical;Medical Marijuana;Metabolic;Methods;Microglia;Motor Activity;mouse model;multidisciplinary;Mus;nanocarrier;nanoformulation;nanoparticle;nanoparticle delivery;Nanotechnology;Nerve Degeneration;neuroAIDS;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neurogenesis;neuroinflammation;Neurologic;Neuronal Plasticity;Neurons;neurotoxicity;novel;Patients;Peripheral;Pharmaceutical Preparations;Plants;prevent;Prevention;Production;Property;Proteins;Receptor Activation;Reporting;research study;response;Role;Surface;synthetic cannabinoid;System;tat Genes;tat Protein;Technology;Therapeutic;Time;Transgenic Mice;Treatment Efficacy;Viral Load result

PROJECT_TITLE: Targeting Inflammasome with stable endocannabinoid ligand AMG315. CRISPR/Cas9 and nanotechnology study in the context of HIV and cannabinoid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE  The ability of mosquitoes to detect, process, and respond to olfactory information emitted by their hosts can affect disease transmission. The magnitude of their responses to odors varies drastically throughout the day, but, despite their clear epidemiological relevance, the neural and molecular mechanisms acting at the circuit levels to control mosquito behavior remain to be determined. The proposed research will employ an interdisciplinary approach combining behavioral assays, electrophysiological recordings, transcriptomic analysis, and CRISPR/Cas9 gene editing, to characterize rhythms in odorant detection, perception, and olfactory behavior, thereby identifying the genetic basis of the temporal plasticity in mosquito-host interactions.

PI_NAMEs: VINAUGER, CLEMENT  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Affect;Afferent Neurons;Arrhythmia;base;Beds;Behavior;Behavioral;Behavioral Assay;behavioral plasticity;behavioral response;Biological Rhythm;Bite;Blood;Brain;cell type;Cells;Cessation of life;Characteristics;Chronobiology;circadian;circadian pacemaker;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cues;Culicidae;Data;Dengue Virus;Detection;disease transmission;Dissection;Electrophysiology (science);Epidemiology;experimental study;Flying body movement;Gene Expression;Genes;Genetic;Goals;human pathogen;improved;innovation;Insecticide Resistance;Insecticides;insight;interdisciplinary approach;Knock-out;Knowledge;Lobe;Mediating;Methods;Molecular;molecular clock;molecular marker;Molecular Mechanisms of Action;Monitor;Mosquito Control;mutant;Nature;neural;Neurons;Odorant Receptors;odorant-binding protein;Odors;Orthologous Gene;Pacemakers;Pattern;Perception;Periodicity;Peripheral;Physiological;Plasmodium falciparum;Population;Probability;Process;Regulation;Research;resilience;response;Sensory;single-cell RNA sequencing;Smell Perception;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;Translating;transmission process;Variant;vector management strategies;Volatilization;Work

PROJECT_TITLE: Neural and molecular rules of mosquito olfactory rhythms

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Although the gut microbiome and human genetic variation are both associated with disease, we do not know their relative contributions and how they interact to affect host health. Here, we propose to use a combination of genomic, computational, and experimental techniques to quantify the heritability of microbiome functions, characterize associations between host and microbial genes, and identify microbiome strains, genes, and pathways that regulate host gene expression. Results from this project will generate unprecedented insight on the interaction between host genetics and the microbiota across populations and disease states, and will facilitate the development of novel microbiome-based diagnostics and therapeutics.

PI_NAMEs: BLEKHMAN, RAN  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Affect;Area;Binding;Biological Models;Complex;Computational Technique;design;Development;Diagnostic;Disease;Environment;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Variation;genomic data;Genomics;Goals;gut microbiome;Health;Heritability;host microbiome;Human;Human body;human disease;Human Genetics;human genomics;improved;In Vitro;Individual;insight;Knowledge;Laboratory Research;Maps;Methods;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome components;microbiome composition;microbiome therapeutics;microbiota;novel;Pathway interactions;Physiology;Population;Primates;programs;Research;System;Techniques;Therapeutic;Time;trait;Variant

PROJECT_TITLE: Population Genomics of Host-Microbiome Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE This work will use molecular diagnostic methods to define the epidemiology and impact of infections with diverse Campylobacter species in children in low-resource settings, many of which have been poorly characterized or missed by traditional culture-based approaches. It will define the specific mechanisms underlying the association between Campylobacter infections and linear growth faltering and identify the primary reservoirs and pathways for transmission of Campylobacter to young children in an endemic setting. Successful completion of this work will lead to interventional studies designed to reduce Campylobacter infections and associated malnutrition.

PI_NAMEs: PLATTS-MILLS, JAMES ALEXANDER (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;African;antimicrobial;Archives;Award;Bangladesh;Birth;Campylobacter;Campylobacter coli;Campylobacter hyointestinalis;Campylobacter infection;Child;Chronic;cohort;Cohort Studies;Communicable Diseases;cytolethal distending toxin;Data;Development;Diagnostic;diagnostic strategy;Diarrhea;DNA;Enteral;enteric infection;Environment;Epidemiology;Etiology;Evaluation;exposure pathway;Exposure to;Failure;Feces;Funding;Genes;Goals;Growth;High Prevalence;Hormonal;Hygiene;Immune response;Impairment;improved;Incidence;Individual;Infection;inflammatory marker;Infrastructure;innovation;International;Intervention;Intervention Studies;Knowledge;Life;Malnutrition;mathematical model;Metabolic;microbiota;Modeling;Molecular;Molecular Diagnostic Techniques;molecular diagnostics;Motility;next generation;next generation sequencing;Niacinamide;Outcome;Output;pathogen;Pathway interactions;Peru;Prevalence;programs;Protozoa;Research;Research Design;Research Personnel;Resource-limited setting;Risk Factors;Route;Rural;Sampling;Sanitation;Schedule;Site;Small Intestines;stool sample;Tanzania;Testing;transmission process;Water;Work

PROJECT_TITLE: Epidemiology and impact of diverse Campylobacter species in low-resource settings

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PUBLIC HEALTH SIGNIFICANCE One in eight US women is expected to develop an invasive breast cancer in her lifetime, and among the various breast cancer subtypes, triple-negative breast cancer (TNBC) carries the worst prognosis, in part, due to a lack of effective therapies. Mutations in p53 are present in over 80% of TNBCs, and we have found that ASAH1 is required for tumor and metastatic growth of p53-mutant TNBCs. The results of the experiments proposed in this application will establish the role of ASAH1 in promoting p53-mutant TNBC tumor growth and metastasis, as well as investigate the translational potential of ASAH1 inhibitors for p53-mutant TNBC therapy.

PI_NAMEs: GUPTA, ROMI  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: adenylate kinase;American;Amidohydrolases;Attenuated;Automobile Driving;Basic Science;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;cancer subtypes;cancer therapy;Cell Culture Techniques;Cell membrane;Cell Nucleus;Cell Survival;Ceramidase;Ceramides;Characteristics;chemotherapy;Clinical;Combined Modality Therapy;CRISPR/Cas technology;Data;Dependence;Development;Diagnosis;Disease;Doxycycline;Drug Targeting;effective therapy;Enzymes;ERBB2 gene;Estrogen receptor positive;experimental study;Fatty acid glycerol esters;Female;Genes;Genetic;Glucose;Glucose Transporter;Growth;Guide RNA;Human;humanized mouse;Immune Evasion;Immune system;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;improved;in vivo;inhibitor;Injections;innovation;knock-down;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Measures;Mediating;Metabolic;Metabolic Pathway;metabolome;metabolomics;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;National Cancer Institute;Neoplasm Metastasis;neoplastic cell;non-genetic;Normal Cell;novel therapeutic intervention;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Precision therapeutics;prevent;Prognosis;Proteins;Public Health;Repression;response;Role;Sampling;Series;SLC2A1 gene;small hairpin RNA;small molecule;small molecule inhibitor;Starvation;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;timeline;TP53 gene;translational potential;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Up-Regulation;Woman;Xenograft procedure

PROJECT_TITLE: PRECISION METABOLIC THERAPY OF p53 MUTANT TRIPLE NEGATIVE BREAST CANCERS

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Heart failure which afflicts nearly 5 million people in the United States, and an additional 550,000 new cases are diagnosed each year. Non-compaction (LVNC) is the third most common cardiomyopathy with an estimated prevalence from 4.5 to 26 per 10,000 adult patients referred for echocardiographic diagnosis; however, there remains a poor genotype-phenotype association in LVNC patients, and a paucity of knowledge on the biomechanical forces underlying the initiation and organization of trabeculation and compaction during cardiac development. For these reasons, our multi-disciplinary team seeks to embrace advanced optics, genetic animal models, and precise computation to provide mechanotransduction insights into the organization of cardiac trabeculation for ventricular structure and function.

PI_NAMEs: HSIAI, TZUNG K (contact);MARSDEN, ALISON L

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Adult;Animal Genetics;Animal Model;Arrhythmia;automated segmentation;autosome;Biomechanics;Budgets;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Collaborations;Congenital Heart Defects;Custom;deep learning;Development;Diagnosis;Diastole;Disease;Echocardiography;erbB-2 Receptor;ERBB2 gene;Event;Failure;Functional disorder;gene interaction;Genetic;Genotype;Goals;Heart;Heart failure;hemodynamics;Hereditary Disease;high risk;Image;in silico;indexing;insight;interdisciplinary approach;Kinetics;Knowledge;Lasers;Left ventricular non-compaction;Ligands;Light;Link;Liquid substance;Malignant - descriptor;Mechanics;mechanotransduction;Mediating;Morphogenesis;multidisciplinary;Muscle Cells;Mutation;Myocardial;Myocardial Contraction;Myocardium;Myopathy;Non-compaction cardiomyopathy;notch protein;Optics;Oxygen;Pathway interactions;Patients;Perfusion;Persons;pharmacologic;Phenotype;preservation;Prevalence;Proliferating;receptor;shear stress;Signal Transduction;skeletal;Structure;superresolution imaging;System;Testing;Time;ultra high resolution;United States;vector;Ventricular;Ventricular Dysfunction;Ventricular Function;Ventricular Remodeling;Viscosity;Zebrafish

PROJECT_TITLE: Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and Function

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: CENTER OVERVIEW: Project Narrative For the last 35 years, the Joslin Diabetes Research Center has provided critical infrastructure to catalyze groundbreaking diabetes research efforts at Joslin, at Harvard, and in the broader research community. Contributions of the Center’s Cores, Pilot & Feasibility Program, and Enrichment Program can be measured by their heavy use by 49 Joslin Research Base investigators and more than 40 outside investigators in the Boston area, and by the seminal publications that have benefitted from Center support. The Joslin Diabetes Center fosters collaborative, multidisciplinary approaches across the basic and translational spectrum to advance our understanding of diabetes and related metabolic disorders and to develop new treatments and preventive strategies for the disease and its complications.

PI_NAMEs: SCHAFFER, JEAN E. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Area;Awareness;base;Biomedical Research;Boston;Caring;catalyst;Clinic;Clinical;Clinical Sciences;clinical translation;collaborative environment;Communication;Communities;community organizations;Complex;Complications of Diabetes Mellitus;design;Development;diabetes education;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;Disease;Education;Ensure;Equity;Evolution;Faculty;Fostering;Funding;Future;Growth;Human;improved;Individual;Infrastructure;innovation;insight;Institution;instrumentation;interdisciplinary approach;Interdisciplinary Study;interest;Investigation;Knowledge;Leadership;Massachusetts;Measures;medical schools;meetings;Mentored Clinical Scientist Development Program;Metabolic Diseases;Metabolism;Movement;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutic intervention;operation;Pathogenesis;Postdoctoral Fellow;Prevention;Prevention strategy;Productivity;programs;Publications;Recording of previous events;recruit;Research;Research Personnel;Resources;Role;Seminal;service delivery;Services;Students;success;summer research;System;Talents;Technology;Training and Education;Translating;translational pipeline;Translational Research;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Advisory Committees;Area;base;bench-to-bedside translation;Biomedical Research;Boston;Clinical Sciences;Collaborations;Communication;Communities;Core Facility;design;Development;Diabetes Mellitus;driving force;Effectiveness;Environment;Evolution;Fostering;Funding;Goals;Guidelines;Infrastructure;innovation;Institution;Institutional Policy;Laboratories;Leadership;medical schools;Metabolic;Metabolic Diseases;Metabolism;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Office of Administrative Management;operation;Productivity;programs;Research;Research Personnel;Scientific Advances and Accomplishments;Self Assessment;Technology;United States National Institutes of Health;Vision

PROJECT_TITLE: Administrative Core


PI_NAMEs: GOODYEAR, LAURIE J (contact)

PROJECT_TERMS: animal imaging;Animal Model;Animals;Area;base;Biometry;Blood flow;Blood Glucose;Blood Pressure;Body Composition;Bone Density;Cells;Cellular Metabolic Process;clinical investigation;Collaborations;Collection;Consult;Data Collection;Diabetes Mellitus;Diabetic mouse;Disease Progression;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Energy Metabolism;Equipment;Evaluation;Exercise;Exposure to;Feces;food consumption;Functional disorder;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Genomics;Germ-Free;glucose tolerance;Gnotobiotic;Hand Strength;Home;Human;Human Resources;Hyperoxia;Hypoxia;Imaging technology;improved;in vivo;in vivo imaging system;in vivo Model;Incubators;insight;Institution;Insulin Resistance;investigator training;Journals;Lasers;Martes zibellina;Measurement;Measures;Medicine;Metabolic;Metabolic Diseases;Metabolism;meter;microbiome;microscopic imaging;Molecular;Monitor;mouse model;Mus;muscle strength;Nature;novel;Obesity;optical imaging;Paper;perfusion imaging;Phenotype;Physiological;Physiology;pre-clinical;Prevention;Procedures;Publications;Publishing;Rattus;Reporter;Research;Research Design;Research Personnel;retinal imaging;Rodent;Role;Services;System;Tail;Technology;Temperature;Testing;Therapeutic Intervention;trafficking;Training;translational medicine;translational potential;Translational Research;treadmill;Urine;Water consumption

PROJECT_TITLE: Animal Physiology Core


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Diabetes;Nutrition;Physical Activity;Prevention

PI_NAMEs: LAFFEL, LORI M (contact)

PROJECT_TERMS: Adipose tissue;Adult;Algorithms;Angiography;Anthropometry;Back;base;biobank;Biological;Biology;Blood Vessels;Body Composition;Bone Density;Brown Fat;Caring;Catalogs;Childhood;Clinic;Clinical Data;clinical epidemiology;clinical investigation;Clinical Investigator;Clinical Research;clinical translation;clinical trial implementation;Clinical Trials;Closure by clamp;Cohort Analysis;Collaborations;Collection;Complex;Consultations;Continuous Glucose Monitor;Core Facility;Data;Data Analyses;data management;design;Development;Diabetes Mellitus;Dietary Intervention;Dual-Energy X-Ray Absorptiometry;Electroretinography;Energy Metabolism;epidemiology study;Equipment;euglycemia;Evaluation;Evolution;Exercise;exercise intervention;Exercise Test;exercise training;Family;Fatty acid glycerol esters;first-in-human;fitness;Functional disorder;Funding;Glomerular Filtration Rate;Glucose;Home;Human;Hyperglycemia;Hypoglycemia;improved;Infrastructure;Infusion procedures;Institution;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;interdisciplinary collaboration;Intravenous;Investigation;Link;Liquid substance;man;Measurement;Measures;Mentors;Metabolic;Metabolic Diseases;Metabolism;Methodology;Methods;Modeling;Muscle;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Optical Coherence Tomography;Oral;Patient Care;patient oriented;patient population;pediatric patients;Performance;pharmacokinetics and pharmacodynamics;pharmacologic;Physiological;Physiological Processes;Population;Prevention;Procedures;Process;programs;Protocols documentation;Publications;Research;Research Design;Research Personnel;Resources;Retina;Sampling;Science;Scientist;Services;skin biopsy;Skin Tissue;Specimen;Techniques;technology intervention;Testing;Tissue Sample;Tracer;Training;Translating;translational impact;Translational Research;translational research program;translational study;treatment optimization;type I and type II diabetes;Visualization

PROJECT_TITLE: Clinical Translational Research Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE A major problem facing clinicians is their inability to identify idiopathic pulmonary fibrosis (IPF) patients who will experience rapid progression before irreversible loss of lung function occurs. The proposed research will fill a significant void in pulmonary medicine through integration of longitudinal clinical data with chromatin accessibility and gene expression to uncover biologically relevant pathways that drive, or result from, disease course variability. The results will form an innovative platform in which to explore the biologic underpinnings and identify patients at high-risk for rapid IPF progression.

PI_NAMEs: NEWTON, CHAD ALAN (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Acute;Architecture;Asthma;ATAC-seq;Automobile Driving;Behavior;Bioinformatics;Biological;Blood;Blood Cells;Cessation of life;Chromatin;Chromatin Structure;Chronic Obstructive Pulmonary Disease;cigarette smoke;Clinical;clinical care;Clinical Data;cohort;Collection;Cystic Fibrosis;Data;design;Disease;Disease Progression;disorder risk;DNA;Dyspnea;Enrollment;Environment;Environmental Exposure;Epigenetic Process;epigenetic regulation;Etiology;experience;Fibrosis;fibrotic lung disease;Foundations;Functional disorder;gene discovery;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Markers;genetic variant;genomic biomarker;Genomics;Goals;Heterogeneity;high risk;Hypoxemia;idiopathic pulmonary fibrosis;Impairment;improved;Individual;Inflammation;innovation;Light;Lung Diseases;Lymphocyte;Mentors;Molecular;Molecular Biology;molecular marker;Molecular Profiling;next generation sequencing;novel;novel marker;Outcome;Pathogenicity;Pathway interactions;Patients;Pattern;personalized management;Phenotype;Physicians;predict clinical outcome;predictive modeling;Proliferating;prospective;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonology;Regulation;Regulatory Element;Research;Research Personnel;Risk;RNA;Scientific Advances and Accomplishments;Scientist;statistics;Susceptibility Gene;Technical Expertise;Technology;telomere;Telomere Maintenance Gene;Testing;tool;Training;transcriptome;transcriptome sequencing;translational impact;Translational Research;Vital capacity

PROJECT_TITLE: Molecular Markers of Idiopathic Pulmonary Fibrosis Progression

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Nanoscale vesicles are known to shed from tumor cells into the blood stream, carrying with them the molecular signatures of pancreatic cancer. We propose an innovative, clinically practical approach to probe the RNA contained within these nanoscale vesicles to better understand the disease's development and spread. Our rapid and multiplexed platform is designed to offer uniquely high precision to diagnose and to guide physicians towards the most efficacious treatments, offering tremendous benefits for patients.

PI_NAMEs: CARPENTER, ERICA ;ISSADORE, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Algorithms;Benchmarking;Benign;Biological Assay;Biological Markers;Blinded;Blood;Blood specimen;CA-19-9 Antigen;Cancer Etiology;cell free DNA;Cell Line;cell type;Cessation of life;Classification;Clinical;clinical diagnostics;cohort;Data;Data Set;design;Detection;detection limit;detection sensitivity;Development;Diagnosis;Diagnostic;diagnostic signature;diagnostic value;Disease;Disease Progression;disorder control;Distant Metastasis;drug efficacy;Early Diagnosis;efficacious treatment;Elements;Endoscopic Biopsy;Endoscopy;Environment;Evaluation;extracellular vesicles;Goals;Hour;Image;improved;Individual;innovation;instrumentation;KRAS2 gene;Lesion;liquid biopsy;Localized Disease;Machine Learning;machine learning classification;machine learning classifier;Magnetic Resonance Imaging;Magnetism;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacturability;Membrane Proteins;Messenger RNA;Methods;microfluidic technology;MicroRNAs;Modeling;Molecular Profiling;Monitor;multimodality;Mutation Detection;nanofluidic;nanoparticle;nanopore;nanoscale;Neoplasm Metastasis;neoplastic cell;next generation;noninvasive diagnosis;novel strategies;Nucleic Acids;operation;Operative Surgical Procedures;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Patient-Focused Outcomes;Patients;Performance;physical property;Physicians;Plasma;Positron-Emission Tomography;predictive panel;prognostic signature;protein expression;Proteins;Resectable;RNA;RNA Probes;Role;Sampling;screening;Sorting;Staging;standard of care;Stream;Surface;Technology;Testing;Training;treatment response;tumor;tumor DNA;Tumor-associated macrophages;Tumor-Derived;United States;Validation;Vesicle;Work;X-Ray Computed Tomography

PROJECT_TITLE: Combining Machine Learning and Nanofluidic Technology for The Multiplexed Diagnosis of Pancreatic Adenocarcinoma


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics

PI_NAMEs: WAGERS, AMY JO (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Antibodies;Apoptotic;Atherosclerosis;autoimmune pathogenesis;Bar Codes;base;Biology;Boston;Cell Count;Cell Physiology;Cell Separation;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Collaborations;Communities;Complex;Consultations;cost efficient;Data;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;Dissection;DNA;Educational Activities;Endothelium;Equipment;Flow Cytometry;Functional disorder;Funding;Gene Expression Profiling;Genotype;Hematopoietic;Human Resources;Immunology procedure;improved;Inflammatory;instrument;instrumentation;Investigation;Islet Cell;Islets of Langerhans;Kidney Diseases;Liver;Metabolic;Metabolic Diseases;Metabolism;Methodology;Methods;molecular phenotype;Muscle;Muscle Cells;Nervous System;novel;novel strategies;Pancreas;Pathogenesis;Phenotype;phenotypic biomarker;Population;programs;protein expression;Proteins;Publications;Reader;Research;Research Personnel;response;Retina;Sampling;screening;Services;Signaling Molecule;single-cell RNA sequencing;Sorting;Speed;Stains;Structure of beta Cell of islet;Technology;technology development;Thymus Gland;Tissues;Training and Education;Update

PROJECT_TITLE: Flow Cytometry Core


PI_NAMEs: DORIA, ALESSANDRO  (contact)

PROJECT_TERMS: Area;Automation;bacteria classification;base;Basic Science;biobank;Bioinformatics;Biological Assay;Biological Markers;Biostatistics Core;Cell Nucleus;Cell Separation;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin Structure;Clinical Research;clinical translation;Collaborations;Collection;Communities;Consultations;cost;Coupled;Custom;Data Analyses;Data Storage and Retrieval;Databases;density;Development;Diabetes Mellitus;digital;Disease;DNA;DNA analysis;Drops;Equipment;Fee-for-Service Plans;Flow Cytometry;Funding;Gene Expression Profiling;Genes;Genetic;Genomics;Genotype;Genus Hippocampus;Human;improved;Individual;Institution;instrument;Insulin-Dependent Diabetes Mellitus;Laboratories;Libraries;Mediation;Metabolic Diseases;metabolic phenotype;metabolic rate;Methodology;Molecular;molecular phenotype;nano;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Phenotype;pilot trial;Preparation;Price;Productivity;Proteomics;Publications;Quality Control;Research;Research Personnel;research study;response;RNA;Role;Sampling;Secure;service programs;Services;single nucleus RNA-sequencing;SNP genotyping;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrophotometry;Taxonomy;Techniques;Technology;Time;Tissues;Training;Training Programs;Translational Research;translational study;Update;Work

PROJECT_TITLE: Molecular Phenotyping and Genotyping Core