NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cancer;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Maternal Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pregnancy;Prevention;Skin Cancer;Women's Health Research

PI_NAMEs: GANDJBAKHCHE, AMIR H (contact)

PROJECT_TERMS: Abdomen;absorption;Address;Adult;adverse pregnancy outcome;Affect;Air;Algorithms;Anatomy;Anemia;anti-cancer research;Area;Artificial Intelligence;at-risk pregnancies;autoencoder;Awareness;barometric pressure;Behavior;Biological Phenomena;Biophotonics;Biosensor;Blood;Blood Gas Analysis;Blood specimen;Brain;Breathing;Breathing Exercises;Cells;Cerebral Hypoxia;Cerebrovascular Circulation;Cerebrum;chromophore;Classification;Clinical;Clinical effectiveness;Clinical Protocols;Clinical Research;Collaborations;Computer Simulation;convolutional neural network;coronavirus pandemic;Country;COVID-19;Data;Data Set;deep learning algorithm;design;Detection;detector;Devices;Diagnostic Procedure;Disease;Elements;Exhibits;experimental study;Exposure to;fetal;Fetal Development;Fetus;Gases;Heart;Heart Arrest;heart function;Hela Cells;Hemoglobin;Hypotension;Hypoxia;Hypoxic Brain Damage;Image;improved;in vivo;Incubators;Individual;Institutional Review Boards;instrumentation;Intensive Care Units;Interruption;Intervention;Knowledge;Label;Left;Legal patent;Lesion;Localized Skin Lesion;Location;Longitudinal Studies;Measurement;Measures;Medical center;Melanoma;Metabolic;Metabolism;Methodology;Methods;Michigan;miniaturize;Monitor;Morbidity - disease rate;motion sensor;multimodality;National Institute of Child Health and Human Development;Near-Infrared Spectroscopy;Network-based;Neural Network Simulation;novel;novel diagnostics;Nutrient;obstetric care;Optical Coherence Tomography;optical imaging;Optics;Oxygen;Oxyhemoglobin;Partial Pressure;Patient Monitoring;Patients;Pattern;Perinatology;Photography;Physiological;Placenta;Pregnancy;Pregnancy Outcome;Privatization;Property;Protocols documentation;radial artery;relative cost;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Respiratory Disease;response;Risk;Scanning;Scientist;screening;sensor;Shapes;Shortness of Breath;Signal Transduction;Site;Skin Cancer;skin lesion;Source;spectrograph;Spectrum Analysis;Stream;success;Surface;System;Techniques;Technology;Temperature;Testing;Texture;theories;Time;time use;Tissue imaging;tissue oxygenation;Tissues;tomography;tool;Traumatic Brain Injury;Tube;United States National Institutes of Health;Universities;Upper Extremity;Vascular blood supply;volunteer;wearable device;wearable sensor technology;wireless

PROJECT_TITLE: Quantitative Biophotonics for Tissue Characterization and Function


ACTIVITY: ZIA

ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Lymphatic Research

PI_NAMEs: WEINSTEIN, BRANT  (contact)

PROJECT_TERMS: Adult;Affect;Anatomy;Animals;Atlases;Axilla;blood vessel development;Blood Vessels;cell type;Cells;Clinical;Collaborations;Cues;Defect;Development;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Epigenetic Process;Ethylnitrosourea;experimental analysis;Fishes;Fresh Water;Gases;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Germ Cells;Gills;Goals;high resolution imaging;Image;Imaging Device;imaging modality;Immune;in vivo;in vivo imaging;insight;interest;Intubation;Investigation;Life;Lung;lymph nodes;Lymphatic Endothelial Cells;lymphatic vessel;lymphoid organ;Maintenance;Meninges;Methodology;Methods;microangiography;microscopic imaging;Modeling;Molecular;Molecular Analysis;Morphogenesis;Mutagenesis;mutant;neuronal guidance;Nutrient;Optics;Organ;Oxygen;Pattern;Phenotype;Play;Population;positional cloning;Proteins;Proteomics;Rapid screening;Reporting;RiboTag;Role;Signal Transduction;Specific qualifier value;Spermatogenesis;Stroke;Testis;Tissues;tool;transcriptomics;Transgenic Organisms;translatome;tumor progression;Universities;Vascular Endothelial Growth Factors;Vascular Endothelium;Venous;Vertebrates;Visualization;Work;wound healing;Zebrafish;zebrafish development

PROJECT_TITLE: Specification And Patterning of Developing Blood Vessels


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: CHITNIS, AJAY B (contact)

PROJECT_TERMS: Amphibia;antagonist;Apical;Behavior;Binding;Body Surface;Body System;bone morphogenetic protein receptors;cell community;cell fate specification;cell motility;Cells;constriction;Deposition;Development;DUSP6 protein;Ear;Ectopic Expression;Embryo;Environment;Epithelium;Exposure to;Family member;Fertilization;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fishes;gene function;Genetic;Goals;Growth;Hair Cells;Hour;inhibitor;knock-down;lateral line;Length;Ligands;Mesenchymal;migration;Modeling;Morphogenesis;Morphology;Natural regeneration;Nervous System;neuromast;Organ;Pathway interactions;Pattern;Periodicals;Phosphoric Monoester Hydrolases;prevent;Primordium;Production;progenitor;Proliferating;promoter;receptor;response;Role;self organization;Sensory;Sensory Hair;sensory system;Side;Signal Transduction;Skin;Specific qualifier value;stem cells;Stereotyping;Supporting Cell;System;Tail;Testing;Time;Transgenic Organisms;water flow;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Building the Posterior Lateral Line system In Zebrafish Embryos


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

PI_NAMEs: ZIMMERBERG, JOSHUA  (contact)

PROJECT_TERMS: 2019-nCoV;Abbreviations;Actin-Binding Protein;Actins;Acylation;Adhesions;Affect;Amino Acid Sequence;Amino Acids;Aminoacylation;Anti-Bacterial Agents;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Area;Arginine;Attention;Avian Influenza A Virus;Basic Amino Acids;betacoronavirus;Binding;Binding Proteins;Buffers;Capsid Proteins;cell fixing;Cell membrane;Cell model;Cell Physiology;Cells;Cellular Structures;Cetylpyridinium Chloride;Charge;Cholesterol;Conserved Sequence;Cysteine;Cytoplasmic Tail;Cytoskeletal Proteins;Cytoskeleton;density;Detergents;Development;Drug Design;Drug resistance;Drug Targeting;Ebola;Ebola virus;Electrostatics;Endoplasmic Reticulum;env Gene Products;Excision;Exocytosis;Face;Family;Fluorescence;Glycine;Glycoproteins;Head;Health;Hemagglutinin;HIV;HIV-1;Human;Hydrophobic Interactions;Hydrophobicity;Impairment;improved outcome;in vivo;Influenza A virus;Influenza B Virus;Influenza Hemagglutinin;influenza virus strain;influenzavirus;interest;Interruption;Ions;Life Cycle Stages;Lipid Bilayers;Lipid Binding;Lipids;Location;Lysine;Mammalian Cell;MARCKS gene;Measles;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Methods;Micelles;Microscopy;Minor;molecular dynamics;Morbidity - disease rate;Morphology;mortality;Mutate;Mutation;nanoscale;novel;palmitoylation;Pathway interactions;Pattern;PH Domain;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phospholipase C;photoactivation;platelet protein P47;Play;Population;prevent;Process;Property;Proteins;quaternary ammonium compound;Regulation;Reporting;response;Role;Sequence Analysis;Serine;Site;Site-Directed Mutagenesis;superresolution microscopy;Surface;Tail;Techniques;Temperature;Testing;trafficking;Transmembrane Domain;vaccine efficacy;Viral;Viral Proteins;Virus;Virus Assembly;Virus Diseases;Virus-like particle;Water;Work

PROJECT_TITLE: Membrane Remodeling in Viral Infection and Viral Assembly


NIH_SPENDING_CATS: Aging;Brain Cancer;Brain Disorders;Cancer;Muscular Dystrophy;Neurosciences;Rare Diseases

PROJECT_TERMS: Acceleration;Adult;age related;age related changes;aged;Aging;Annexin A1;Behavior;Biogenesis;Biological;biomarker discovery;Biophysics;Blood Vessels;Brain;Brain Glioblastoma;brain parenchyma;brain tissue;cancer cell;CD147 antigen;Cell Communication;Cell membrane;cell motility;Cell Physiology;Cell Proliferation;Cell secretion;Cell Survival;Cells;Characteristics;chemotherapy;Classification;Consensus;Cues;Data;Disease Progression;Distal;drug discovery;drug testing;DYSF gene;dysferlinopathies;Electron Microscopy;endosome membrane;Endosomes;Endothelial Cells;Endothelium;Environment;Excision;Exocytosis;exosome;extracellular;extracellular vesicles;Female;Fluorescence Microscopy;Genetic Diseases;Genomics;Glioblastoma;Glioma;Goals;healing;Hela Cells;Heterogeneity;Human;human disease;human migration;human model;human tissue;immune cell infiltrate;Immunohistochemistry;implantation;Individual;Infiltration;Inflammation;inhibitor;Injury;Invaded;Investigation;Label;Laboratories;Left;life span;Ligands;Limb-Girdle Muscular Dystrophies;Lipids;liquid chromatography mass spectrometry;Maintenance;male;Malignant neoplasm of brain;MAP Kinase Gene;Mass Spectrum Analysis;mast cell;Mediating;Membrane;Metalloproteases;Methodology;microvesicles;migration;Mitogens;Modeling;Molecular;Movement;Multivesicular Body;Mus;Muscle;muscle aging;Muscular Dystrophies;Mutation;Myopathy;nanovesicle;Natural regeneration;neoplastic cell;novel;novel therapeutic intervention;Nucleic Acids;Oncogenic;Operative Surgical Procedures;Parasites;Pathway Analysis;Pattern;Pericytes;personalized medicine;Phosphotransferases;PIK3CG gene;Play;Post-Translational Protein Processing;preference;prevent;Primary Brain Neoplasms;Property;protein biomarkers;Proteins;Proteome;Proteomics;quadriceps muscle;Radiation therapy;Receptor Activation;Receptor Protein-Tyrosine Kinases;repaired;Reproducibility;Research Design;Resistance;response;Role;Sarcolemma;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Slice;Speed;Stem Cell Factor;Stress;Structure;Surface;Surgical margins;Surgically-Created Resection Cavity;System;Techniques;Technology;Therapeutic;therapy resistant;Time;Time trend;Tissues;transcriptomics;Tropism;tumor;tumor microenvironment;tumor progression;Variant;Vesicle;virtual;Wild Type Mouse;Work;wound;wound healing

PROJECT_TITLE: Biophysical Membrane Mechanisms of Exocytosis inside Extracellular Vesicles, Membrane Repair Failing in Muscular Dystrophy, and Parasite Replication


PI_NAMEs: ROUAULT, TRACEY A. (contact)

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Aconitate Hydratase;Adult;aerobic glycolysis;Affect;Alternative Splicing;Anemia;Animals;Attenuated;axonal degeneration;Axonal Transport;axonopathy;behavior test;Behavioral;Binding;Binding Proteins;Blood Vessels;cancer cell;Cancer cell line;Cancer Etiology;Cell Death;Cell Line;Cells;Cessation of life;Child;Cognitive;Collaborations;Compensation;Complex;coronary fibrosis;CRISPR/Cas technology;dietary;Dietary Supplementation;Disease;Duodenum;Electrophysiology (science);Elements;Embryo;embryo cell;Endothelium;Enzymes;Erythroblasts;Erythrocytes;Erythrocytoses;Erythroid Cells;Erythrophagocytosis;Erythropoietin;Fatty Acids;feature detection;Ferritin;Fibroblasts;Fumarate Hydratase Deficiency;Functional disorder;functional loss;Gait abnormality;Gene Expression Profiling;Genes;Glycogen;Goals;H ferritin;Heme;heme oxygenase-1;Hereditary Leiomyomatosis and Renal Cell Cancer;Histocompatibility;homologous recombination;Human;Hypoxia Inducible Factor;In Vitro;Infant;Infusion procedures;Ingestion;Inherited;inhibitor;insight;interstitial;Iron;iron deficiency;iron metabolism;Iron Regulatory Protein 1;Iron Regulatory Protein 2;Iron-Sulfur Proteins;Kidney;Knock-in Mouse;Knockout Mice;Laboratories;Learning;Leiomyomatosis;Life;life span;Liver;loss of function mutation;Lung;Macrophage;Maintenance;Mammals;Mediating;Messenger RNA;Metabolic;Metabolism;metal transporting protein 1;microcytic anemia;Microfluidics;Mitochondria;Mitochondrial Matrix;Molecular;monocyte;Motor;Motor Neurons;mouse model;Mucous Membrane;multicatalytic endopeptidase complex;Mus;Mutation;Neoplasm Metastasis;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurons;Nutrient;Oligodendroglia;Oral;overexpression;oxidation;oxidative damage;Oxidative Stress;Oxygen;Patients;Pentosephosphate Pathway;pharmacologic;Phenotype;Physiological;Physiology;Polycythemia;Population;preservation;prevent;Production;progressive neurodegeneration;protein function;Proteins;Pulmonary Hypertension;Rare Diseases;Regulation;Renal Carcinoma;Reporting;RNA;Role;senescence;sensor;Sensory;shunt pathway;Source;Spleen;stem;Stimulus;Succinates;Sulfur;Syndrome;System;tempol;TFRC gene;Tissues;trafficking;Transcript;Translational Repression;Translations;tumor metabolism;VHL gene;Wild Type Mouse

PROJECT_TITLE: Regulation Of Intracellular Iron Metabolism


NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Digestive Diseases;Genetics;Infertility;Kidney Disease;Pancreatic Cancer;Pediatric;Rare Diseases;Women's Health Research

PI_NAMEs: LILLY, MARY A (contact)

PROJECT_TERMS: Autophagocytosis;Birt-Hogg-Dube Syndrome;Cancer cell line;Cathepsins;Cell Cycle;Cell Cycle Regulation;Cell Line;Cell model;Cell Nucleus;Cell Proliferation;Cells;Cellular Metabolic Process;Chimeric Proteins;chromosome missegregation;Complement;Complex;Congenital Abnormality;Cytoplasm;Data;Defect;Development;Digestion;DNA Sequence Rearrangement;Drosophila genus;Drosophila melanogaster;egg;Enzymes;Event;event cycle;Failure;Family;Female;Gametogenesis;Genes;Genetic Transcription;Germ Cells;Goals;Growth;Hela Cells;hormonal signals;Human;in vivo;Individual;Invaded;knock-down;Laboratories;Lysosomes;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Meiosis;member;Metabolic;Metabolism;model organism;multicatalytic endopeptidase complex;Mutation;Oncogenic;Oocytes;Oogenesis;pancreatic ductal adenocarcinoma cell;Phosphorylation;programs;protein structure;Proteins;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Reproductive Biology;Reproductive Medicine;Role;Signal Pathway;Spontaneous abortion;System;TFE3 gene;Therapeutic Intervention;transcription factor;UBE3A gene;Ubiquitin;vacuolar H+-ATPase;Xp11.2

PROJECT_TITLE: Cell Cycle Regulation In Oogenesis


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Human Genome;Hypertension;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PI_NAMEs: ROMERO, ROBERTO  (contact)

PROJECT_TERMS: adverse outcome;Affect;amniotic cavity;Angiogenesis Inhibitors;Angiogenic Factor;Antibodies;Atlases;Basal Plate;biomarker identification;Birth;CCL26 gene;Cell Communication;cell type;Cells;Cellular Stress;Cervix Incompetence;Cervix Uteri;Characteristics;chemokine;Circulation;Classification;Clinical;Collagen;Communication;comparative;Complex;cost;Coupled;cytokine;Data;Decidual Cell;Diagnosis;Discipline of obstetrics;Disease;Eclampsia;Eotaxin;Etiology;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;fetus cell;Frequencies;Galactose Binding Lectin;genomic tools;Gestational Age;Goals;Growth;high dimensionality;Homeostasis;Human;IL16 gene;IL8 gene;Immune;Immunoassay;improved;Infection;Inflammation;Inflammatory;Injections;Injury;insight;Interferon Type II;Interleukin 6 Receptor;Interleukin-12;Interleukin-15;Interleukin-16;Interleukin-6;Interleukins;Intervention;intraamniotic infection;Life;Ligands;Macrophage Inflammatory Proteins;macrophage-derived chemokine;maternal morbidity;Maternal Mortality;Measures;Medical;Membrane;Meta-Analysis;microbial;Modality;Monitor;Monocyte Chemoattractant Proteins;mortality;Mothers;mouse model;Myeloid Cells;Nature;Necrosis;Neonatal;neonatal morbidity;Neonatal Mortality;neonatal outcome;Nested Case-Control Study;neurodevelopment;Nucleic Acids;Organ;Pathologic Processes;pathophysiology of preeclampsia;Pathway interactions;Patients;perinatal morbidity;Perinatal mortality demographics;Perinatology;PGF gene;Physiological Processes;Physiology;Placenta;Plasma;Pre-Eclampsia;Pregnancy;Pregnancy Complications;premature;Premature Birth;Premature Labor;prenatal;Prevalence;prevent;Prevention;Process;Progesterone;Proteins;Proteomics;rapid diagnosis;rapid technique;Research;Resolution;Role;Rupture;Science;Second Pregnancy Trimester;Signal Transduction;single-cell RNA sequencing;Site;Sterility;Stromal Cells;Subgroup;Syndrome;System;Term Birth;Testing;Thymus Gland;Time;TNF gene;transcriptomic profiling;transcriptomics;Ultrasonography;ultrasound;United States;Vagina;Vascular Endothelial Growth Factor Receptor-1;Work

PROJECT_TITLE: The Role Of Subclinical Infection And Cytokines In Preterm Parturition


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PROJECT_TERMS: 3-Dimensional;actigraphy;Anatomy;Atopobium vaginae;Biometry;Birth;Body Composition;Breathing;Cervical;Cesarean section;clinical decision-making;clinically relevant;Conceptions;Confidence Intervals;congenital anomaly;Data;Diagnosis;Dimensions;Discipline of obstetrics;early pregnancy;Embryo;Embryonic Development;Epidural Anesthesia;Failure;Female;fetal;Fetal Growth;Fetus;Formulation;Frequencies;Geography;Gestational Age;Growth;heart function;Hematopoiesis;Hour;Image;imaging modality;improved;Induced Labor;instrument;intrapartum;Labor Onset;Light;Link;Longitudinal cohort study;Longitudinal Studies;Machine Learning;machine learning method;Magnetic Resonance Imaging;male;Maternal-fetal medicine;Measures;Membrane;Metabolism;Methods;Modality;Modeling;Mothers;Nulliparity;nutrition;obstetrical syndromes;Optical Methods;Organ;Pattern;Physical activity;Physiological;Play;Predictive Value;Pregnancy;Prenatal Diagnosis;Process;prospective;Role;Rupture;sex;Sleep;Statistical Methods;statistics;Time;two-dimensional;ultrasound;Vaginal delivery procedure;Validation;Woman;Yolk Sac

PROJECT_TITLE: Prenatal Diagnosis Of Congenital Anomalies


NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Disability Research;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: SUNDARAM, RAJESHWARI  (contact)

PROJECT_TERMS: Acute;Adult;ambient air pollution;Basic Science;Biological Markers;Birth;Blood;Cadmium;Chemicals;Clinical Research;Contraceptive methods;County;Couples;Development;Ensure;Environment;environmental chemical;Environmental Impact;Environmental Risk Factor;epidemiology study;Fertility;Human;Infant;Infertility;Interview;Investigation;Lead;Length;Life Style;lifestyle factors;male;Measures;Mediating;men;Menstrual cycle;Mental disability;Metals;Michigan;Mission;National Institute of Child Health and Human Development;organochlorine pollutant;Parabens;Patient Self-Report;Phenols;phthalates;physically handicapped;Phytoestrogens;Polychlorinated Biphenyls;Pregnancy;Pregnancy loss;pregnant;Pregnant Women;Process;prospective;recruit;Reproduction;reproductive outcome;saliva sample;Sampling;Seminal fluid;Serum;Standardization;Stress;Texas;Time;time-to-pregnancy;Urine;Woman

PROJECT_TITLE: Longitudinal Investigation of Fertility and the Environment


PROJECT_TERMS: absorption;Anatomy;Animals;Axilla;blind;Blood;Blood Vessels;brain pericytes;Cardiovascular system;Characteristics;Clinical;Development;Drainage procedure;Embryo;Experimental Models;Fatty acid glycerol esters;Fishes;Fluid Balance;Gene Expression;Genes;Genetic;genetic analysis;Goals;Growth;high resolution imaging;Human;Image;Imaging Device;Immune;Immune response;in vivo;in vivo imaging;in vivo Model;insight;interest;Larva;Liquid substance;Lymph;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelium;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;Lymphocyte;lymphoid organ;Malignant Neoplasms;Meninges;microscopic imaging;model organism;Modeling;Molecular;Morphology;mutant;Neoplasm Metastasis;novel;Optics;Pathologic Processes;Pathology;Pattern;Phenotype;Population;progenitor;Regulation;Resolution;Role;Route;Specific qualifier value;Structure;Systems Development;Tissues;tool;Transgenic Organisms;Trees;tumor;Vascular System;Venous;Vertebrates;Visualization;Work;Zebrafish

PROJECT_TITLE: Specification And Patterning of the Lymphatic System


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Aconitate Hydratase;Apoproteins;Attenuated;Binding;Binding Sites;Biogenesis;Biological Assay;Biological Markers;candidate identification;Carrier Proteins;Cell Nucleus;Cells;Citric Acid Cycle;cofactor;Collaborations;Common Cold;Complex;Coronavirus;COVID-19;cysteine desulfurase;Cytosol;Data;Development;Disabling;Disease;Electron Transport Complex III;Enzymes;Exoribonucleases;Ferredoxin;FGF21 gene;fibroblast growth factor 21;Fibroblasts;frataxin;Friedreich Ataxia;gene product;Genes;Genetic Transcription;Goals;Hamsters;helicase;heme biosynthesis;Homeostasis;Human Cell Line;human coronavirus;human disease;In Vitro;Inductively Coupled Plasma Mass Spectrometry;Infection;Informatics;Iron;iron deficiency;Iron Overload;Iron-Sulfur Proteins;Lactic Acidosis;Ligation;lipoic acid synthase;lymphoblast;Mammalian Cell;Mass Spectrum Analysis;Mediating;metabolic abnormality assessment;Metabolic Pathway;Mitochondria;Mitochondrial Diseases;Mitochondrial Matrix;Molecular Chaperones;Mutagenesis;Mutation;Myopathy;Neonatal;neuromuscular;Nonstructural Protein;Nuclear;Oral;overexpression;Oxidants;oxidation;Oxidoreductase;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptides;Phenotype;Physiological;Plaque Assay;Porphobilinogen Synthase;Primer Extension;Process;Prosthesis;protein function;Protein Isoforms;Proteins;Publishing;rare genetic disorder;Regulation;replicase;Research;respiratory;Respiratory Chain;Respiratory physiology;RNA;RNA Binding;RNA-Binding Proteins;Role;SARS-CoV-2 infection;scaffold;Scaffolding Protein;Scanning;Sideroblastic Anemia;Skeletal Muscle;skeletal muscle metabolism;Specificity;stem;Structure;Study models;Subgroup;Succinate Dehydrogenase;Sulfur;Sulofenur;System;tempol;Thioctic Acid;tissue/cell culture;Tissues;Translations;Viral;Viral Physiology;Virus;Work;Zinc

PROJECT_TITLE: Mammalian iron-sulfur cluster biogenesis


NIH_SPENDING_CATS: Infertility;Pregnancy

PROJECT_TERMS: Address;adverse outcome;Biomedical Research;Child;Complex;Data;Enrollment;Epidemiology;epidemiology study;Event;Goals;interest;Literature;Methods;Modeling;Names;National Institute of Child Health and Human Development;Nature;novel;Pregnancy;Pregnancy loss;pregnant;Prevention Research;prospective;Recurrence;Risk;Risk Factors;Sexual Maturation;Statistical Methods;statistics;Stress;Study models;Survival Analysis;Time;time-to-pregnancy;Woman;Women's study

PROJECT_TITLE: The analysis of survival data


NIH_SPENDING_CATS: Bioengineering;Clinical Research

PI_NAMEs: LIU, AIYI  (contact)

PROJECT_TERMS: Address;Area;Area Under Curve;Biological Markers;biomarker evaluation;Biomedical Research;cost;cost effective;Data;Data Analyses;Data Pooling;detection limit;diagnostic accuracy;diagnostic biomarker;Disease;disease diagnosis;epidemiology study;Evaluation;Health;improved;indexing;Individual;innovation;interest;Literature;Maximum Likelihood Estimate;Measurement;Measures;Methodology;Methods;novel;Outcome;Probability;Procedures;Research;Research Personnel;Research Project Grants;ROC Curve;Sampling;sound;Specificity;Statistical Methods;Test Result;Testing;tool;Visually Impaired Persons

PROJECT_TITLE: Statistical Methods for Evaluation of Biomarkers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Physical Activity

PROJECT_TERMS: Acute;Adult;Age;Area;Beginning of Life;Behavior;Belief;bioelectricity;bioimaging;Biological Markers;Biophotonics;Brain;Brain imaging;Brain region;Categories;cerebral hemodynamics;Child;Child Development;Classification;Cognitive;cognitive ability;cognitive function;cognitive task;cohort;Collaborations;Collection;Color;Coupled;Critiques;Data;data fusion;Data Set;Development;developmental disease;Dimensions;Electroencephalography;Equilibrium;Exercise;Exhibits;expectation;experimental study;Exposure to;France;frontier;functional magnetic resonance imaging/electroencephalography;functional near infrared spectroscopy;healthy volunteer;hemodynamics;Human;Imagery;Imagination;imaging modality;Infant;Inferior;information processing;insight;Institution;interest;Investigation;Journals;Knowledge;Left;Link;Literature;Machine Learning;Maryland;Measures;Medical center;Methodology;Methods;Military Personnel;mirror neuron;Modality;Modeling;Monitor;Motor;Motor Cortex;multimodal data;multimodality;National Institute of Mental Health;neural;neural network;Neurodevelopmental Disorder;neuroimaging;Neurosciences;Optics;Outcome;Parietal;Pattern;Performance;Photic Stimulation;Physical activity;Positioning Attribute;predictive marker;preference;Primates;Psyche structure;Psychiatry;Publications;Publishing;Regenerative Medicine;rehearsal;Reporting;Research;Research Personnel;Resolution;response;Rest;Risk;Role;Scientist;Sensory;Signal Transduction;Stimulus;Structure;systematic review;Systems Integration;Task Performances;TBI Patients;Techniques;temporal measurement;Testing;Tissues;Toddler;Universities;Urea cycle disorders;Visual;Visual attention;visual information;Visual Perception;visual stimulus;Visual System

PROJECT_TITLE: Functional and Structural  Optical Brain Imaging


PROJECT_TERMS: Affect;Behavioral;Biological;Biological Factors;biological heterogeneity;Cervix Mucus;Childbirth;Coitus;Conceptions;Contraceptive Agents;Contraceptive methods;Couples;Data;Demography;Elderly;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiologist;Epidemiology;Exposure to;Female;Fertility;flexibility;Functional disorder;Heterogeneity;high dimensionality;Hormonal;Human;human model;Impairment;infertility treatment;interest;Investigation;Joints;Length;Longevity;male;Measurement;Medical;Menstrual cycle;Methods;Modeling;Names;New York;Ovulation;parity;Pattern;Physiological;Poison;population based;Pregnancy;Probability;prospective;Prospective cohort;Psychosocial Stress;reproductive;Reproductive Biology;Research;Research Personnel;response;Risk Factors;Source;sperm cell;Statistical Models;time-to-pregnancy;Woman

PROJECT_TITLE: Statistical Modeling of Human Fecundity


NIH_SPENDING_CATS: Cerebrovascular;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

PROJECT_TERMS: Adult;Aging;Alleles;Anatomy;angiogenesis;Animals;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain hemorrhage;cell type;Cells;Cephalic;Cerebral endothelium;Cerebrospinal Fluid;cerebrovascular;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Connective Tissue;Craniocerebral Trauma;cranium;Defect;Development;Diabetes Mellitus;Embryo;Endothelium;experimental analysis;Fishes;Fresh Water;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;genetic analysis;genetic regulatory protein;Genetic Screening;Goals;Growth;healing;Image;Immune;Immune response;Impairment;in vivo;Inflammation;Injury;insight;interest;Intubation;Larva;Maintenance;Meningeal;Meninges;Methods;model organism;Modeling;Molecular;Molecular Cloning;Morbidity - disease rate;mortality;mutant;Mutation;Natural regeneration;Neurocognitive Deficit;Neurodegenerative Disorders;new therapeutic target;next generation sequencing;Nutrient;optical imaging;Optics;Organ;Oxygen;Pathology;Pathway interactions;Play;Process;Rapid screening;Reagent;Recovery;Regulation;repaired;Reporting;Resolution;response;rhoA GTP-Binding Protein;Role;Rupture;Series;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Skin wound healing;Stroke;Thinness;Tissues;tool;Trauma;Vascular Diseases;Vascular regeneration;Vertebrates;wasting;wound healing;Wound models;Zebrafish

PROJECT_TITLE: Regulation of Vascular Integrity


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: BANERJEE, ANIRBAN  (contact)

PROJECT_TERMS: Acyl Coenzyme A;Acylation;Anabolism;Anemia;Area;Ataxia;Attention;Binding;Biochemical;Biological;Biological Assay;Biology;biophysical techniques;cancer therapy;Carbon;Catalysis;Cell membrane;Cell Physiology;Cells;Chemicals;cofactor;Collaborations;COVID-19;Cryoelectron Microscopy;Cues;Cysteine;deacylation;design;Disease;Elements;Engineering;enzyme mechanism;Enzymes;Equilibrium;Eukaryota;experimental study;Family;Family member;Genetic;Goals;Heart;Heme;heme biosynthesis;Homeostasis;Human;human disease;Hydrophobicity;In Vitro;in vitro Assay;Individual;inhibitor;insight;Integral Membrane Protein;interest;Intervention;Iron;Iron Overload;knock-down;Knock-out;Knowledge;Lead;Legionella;Legionella pneumophila;Legionnaires' Disease;Link;Lipids;Literature;Macrophage;Maintenance;Malignant Neoplasms;member;Membrane;Membrane Lipids;Membrane Proteins;Membrane Structure and Function;Metabolic;Metal Ion Binding;Metals;Methods;Mitochondria;Molecular;mutant;Mutate;Nature;Neurodegenerative Disorders;neuropsychiatric disorder;novel;Organism;overexpression;oxygen transport;Palmitoyl Coenzyme A;palmitoylation;pathogen;pathogenic bacteria;Peptide Fragments;Pharmacologic Substance;Phosphorylation;Physiological;Play;Pneumonia;Post-Translational Protein Processing;preference;Process;Proliferating;Property;Protein Family;Protein S;Proteins;proteoliposomes;Reaction;Recombinants;reconstitution;Resolution;response;Role;Signal Transduction;Signaling Protein;Starvation;Structure;Sulfur;Surface;synthetic peptide;Time;tool;Touch sensation;Transition Elements;Universities;Vacuole;Virus;X-Ray Crystallography;Zebrafish

PROJECT_TITLE: Structural and chemical biology


PI_NAMEs: MACFARLAN, TODD SCOTT (contact)

PROJECT_TERMS: Alleles;arms race;autism spectrum disorder;Behavior;Binding;Binding Sites;Biochemical;Biological Assay;Birds;Brain;C-terminal;C2H2 Zinc Finger;ChIP-seq;Chromosome Pairing;cohesin;Complex;Data;Defect;Dendrites;Development;Developmental Gene;DNA Binding;DNA Double Strand Break;DNA Repair;driving force;Elements;Endogenous Retroviruses;Ensure;Epigenetic Process;epigenetic silencing;Epitopes;Equilibrium;Evolution;Failure;Family;Female;Fetal Development;Fetal Growth;follow-up;functional genomics;gain of function;gastrulation;Gene Cluster;gene interaction;Gene Proteins;gene repression;Genes;Genetic;genetic corepressor;genetic variant;Genome;Genomic DNA;genomic locus;Germ Lines;Growth Factor;Health;Heart Septal Defects;heterochromatin-specific nonhistone chromosomal protein HP-1;Histone H3;histone methylation;histone methyltransferase;Human;in silico;In Vitro;in vivo;Individual;Infertility;innovation;Insulin-Like Growth Factor II;Knock-out;Knockout Mice;Laboratory Study;Lead;Link;loss of function;male;Male Sterility;Mammals;Mediating;Meiosis;Meiotic Recombination;member;men;Methods;Mouse Strains;Murine leukemia virus;Mus;mutant;Mutation;N-terminal;Neurons;Orthologous Gene;Parasites;Patients;Perinatal;Phenotype;Physiological;Placenta;placental mammal;Placentation;Play;Positioning Attribute;prevent;Production;Proline;proline-tRNA;promoter;Prophase;Protein Family;protein function;Protein Isoforms;Proteins;recruit;reference genome;repaired;Repression;Retrotransposition;Retrotransposon;Retroviridae;Role;SETDB1 gene;Site;Somatic Cell;Somatotropin;Sterility;symbiont;System;Tetrapoda;Time;Tissues;Transcript;transcription factor;Transcription Repressor;Transcriptional Regulation;Viral;Virus Activation;Work;Zinc Fingers

PROJECT_TITLE: Mammalian Development and Evolution


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Women's Health Research

PI_NAMEs: CHEN, ZHEN  (contact)

PROJECT_TERMS: Accounting;Air;Alabama;Asthma;asthmatic;atopy;Biological;Blood Pressure;Breathing;Cells;Chronic Disease;Clinic;Clinic Visits;Clinical;Clinical assessments;clinical center;Clinical Data;Cohort Studies;Data Collection;dietary antioxidant;Dietary intake;Emergency Situation;Environmental Risk Factor;Exhalation;experience;Exposure to;Flow Cytometry;FOXP3 gene;Genetic;Hospitalization;Hypersensitivity;Immune;improved;Inflammation;inflammatory marker;interest;Literature;Mediation;Medical Records;minimal risk;National Heart, Lung, and Blood Institute;neonatal outcome;Nitric Oxide;obstetrical complication;Patients;Pharmaceutical Preparations;Population;Postpartum Period;Predictive Factor;Pregnancy;pregnancy immunology;prenatal;Procedures;Protocols documentation;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Pulse Oximetry;Questionnaires;Recording of previous events;recruit;Regulatory T-Lymphocyte;Reporting;Risk;Risk Factors;Role;Severities;Specimen;Surveys;Symptoms;Universities;Visit;Woman

PROJECT_TITLE: B-WELL-Mom Study


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Dietary Supplements;Infertility;Nutrition;Pregnancy;Prevention

PI_NAMEs: PERKINS, NEIL  (contact)

PROJECT_TERMS: 18 year old;Affect;Age;aged;American Medical Association;Assisted Reproductive Technology;Birth Rate;Body mass index;Caring;Characteristics;Clinic;Collection;college;cost;Couples;dietary supplements;DNA Fragmentation;Double-Blind Method;efficacy evaluation;Eligibility Determination;Etiology;Female;Fertilization in Vitro;Folic Acid;folic acid supplementation;gastrointestinal symptom;General Population;Height;improved;Infertility;infertility treatment;interest;Intervention;Journals;Live Birth;Magnesium;male;male fertility;Marketing;men;Micronutrients;Morphology;Motility;Observational Study;Outcome;Participant;Placebos;Population;Pregnancy;primary outcome;Process;Publications;Publishing;Randomized;randomized placebo controlled trial;randomized trial;recruit;Reporting;reproductive;Seminal fluid;Site;sperm cell;Sperm Count Procedure;Sperm Motility;Spermatogenesis;subfertility;success;Time;treatment arm;Treatment Efficacy;trial design;Visit;Weight;Woman;Zinc;Zinc supplementation

PROJECT_TITLE: Folic Acid and Zinc Supplementation Trial


NIH_SPENDING_CATS: Behavioral and Social Science;Complementary and Integrative Health;Contraception/Reproduction;Dietary Supplements;Infertility;Mental Health;Natural Products;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: adiponectin;Affect;Alcohols;Anxiety;Biological Markers;Caffeine;Carbohydrates;Collection;Conceptions;Consumption;cost;Couples;Data Analyses;Diet;dietary;Dietary Fiber;Dietary intake;Dietary Practices;Disease;Dual-Energy X-Ray Absorptiometry;Embryonic and Fetal Development;Enrollment;Evaluation;Exercise;Fatty acid glycerol esters;Female;Fertility;fertility improvement;Fertility Study;folic acid supplementation;follow-up;Goals;Gynecologic;implantation;Individual;Infertility;infertility treatment;Intake;interest;intimate partner violence;Journals;Leptin;leptin receptor;Life Style;lifestyle factors;male;Measurement;Measures;Mediterranean Diet;men;Mental Depression;Metabolic;modifiable lifestyle factors;Molecular Weight;Obesity;Outcome;Ovulation;Paper;Participant;Physical activity;Phytoestrogens;Pregnancy;Pregnancy Outcome;pregnant;prospective;Psychosocial Factor;Publishing;Questionnaires;recruit;reproductive success;reproductive system disorder;Research Design;Role;Sex Behavior;sleep pattern;Smoking;Stress;United States;urologic;Visit;Vitamin D;Weight;Woman;Women's Role;Zinc supplementation

PROJECT_TITLE: Impact of Diet, Exercise And Lifestyle on Fertility: The IDEAL Fertility Study


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SODT, ALEXANDER  (contact)

PROJECT_TERMS: Affect;Amino Acid Motifs;Biological;Biological Process;Cell Nucleus;Cells;Chemical Structure;Chemicals;cluster computing;Complex;Computer Models;Computer software;Coupling;Cryoelectron Microscopy;Custom;Cytoskeleton;deep ocean;design;Disease;Elements;Environment;Event;Experimental Models;experimental study;Fluorescence Spectroscopy;G-Protein-Coupled Receptors;Goals;Hydrophobicity;Integral Membrane Protein;Intuition;Knowledge;Laboratories;Length;Libraries;Life;lipidome;Lipids;Magnesium;mathematical model;Mechanics;Membrane;Membrane Lipids;meter;Methodology;Methods;Modeling;models and simulation;Molecular;Molecular Biology;Molecular Conformation;molecular dynamics;Movement;nanoscale;National Institute of Child Health and Human Development;Nature;Nervous System Physiology;Neutrons;novel;NUP214 gene;Organelles;Organism;Paper;Pharmaceutical Preparations;physical model;Physics;Post-Translational Protein Processing;pressure;Process;protein function;Proteins;quantum;receptor binding;Research;Resources;response;Role;Running;Sampling;Shapes;side effect;Signal Transduction;Signaling Molecule;Signaling Protein;simulation;software development;Stress;Structure;Techniques;Temperature;Testing;theories;Thick;ultra high resolution;United States National Institutes of Health;Validation;Vesicle;vesicle transport;Viral;Viral Proteins;Virus Replication;Work

PROJECT_TITLE: Molecular simulations of lipid curvature stress and its effect on transmembrane proteins


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: LE PICHON, CLAIRE  (contact)

PROJECT_TERMS: Ablation;activating transcription factor 3;Address;ALS pathology;Anatomy;Animal Model;Apoptotic;Area;Axon;axonal degeneration;Axotomy;Back;Biogenesis;biological adaptation to stress;Brain Concussion;Categories;cell type;Cells;Central Nervous System;Cessation of life;confocal imaging;Cytoprotection;Data;Disease;Dynamin;Early Diagnosis;Early identification;effective therapy;Exhibits;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Human;Human Development;human imaging;Image;Inherited;Injury;Intervention;Lead;Learning;Leucine Zippers;Methods;Mitochondria;Modeling;Molecular;motor neuron development;Motor Neuron Disease;Motor Neurons;mouse development;mouse model;Mus;Mutation;Nerve Degeneration;nerve injury;Neurodegenerative Disorders;neuron loss;Neurons;novel;Pathology;Pathway interactions;Patients;Peptides;Peripheral Nervous System;Personal Satisfaction;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Population;Prevalence;prevent;programs;repaired;Research;resilience;response;response to injury;Risk Factors;Role;Signal Transduction;Site;Sphingolipids;stem;Syndrome;therapy development;transcriptional reprogramming;transcriptomics;Traumatic Brain Injury;Traumatic injury;Travel;ward;Work

PROJECT_TITLE: Mechanisms regulating neuronal degeneration and repair


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cancer;Clinical Research;Neurosciences

PI_NAMEs: BASSER, PETER J. (contact)

PROJECT_TERMS: Address;Aging;Anatomy;Anisotropy;Architecture;Axon;bench to bedside;Biological;Biological Markers;Biomedical Research;Biopsy;Brain;Brain Neoplasms;brain tissue;cancer diagnosis;cancer imaging;Cell membrane;cell water;Cells;Cellularity;Cerebral cortex;Clinic;Clinical;clinical diagnostics;clinically relevant;Color;Communities;Complex;Contrast Media;Data;Data Science;Detection;Development;Diagnostic Neoplasm Staging;Diameter;Diffusion;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Doctor of Philosophy;Dyes;experimental study;extracellular;Foundations;Gel;Glean;Goals;gray matter;Heterogeneity;high dimensionality;Histologic;Histology;Hour;Image;imaging biomarker;imaging modality;improved;in vivo;Individual;innovation;interest;invention;Joints;Length;macromolecule;Magnetic Resonance Imaging;Maps;mathematical model;Mathematics;Measurement;Measures;Methodology;Methods;Microscopic;migration;mild traumatic brain injury;millimeter;Modeling;Monitor;MRI Scans;Multicenter Studies;Multicenter Trials;neural;Neurosciences Research;Normal Statistical Distribution;novel;novel strategies;Outcome;Pathologic;Pathology;Pathway interactions;patient population;physical model;Physiologic pulse;Population;Porosity;pre-clinical;Process;Property;quantitative imaging;Radial;radiologist;reconstruction;Relaxation;Resolution;Scheme;Shapes;Signal Transduction;soft tissue;Specimen;Stains;Statistical Distributions;statistics;Stroke;Structure;submicron;Testing;Time;Tissues;tool;tractography;Translating;Translations;Trauma;tumor;Uncertainty;Visualization;Water;water diffusion;white matter;Work

PROJECT_TITLE: Quantitative Imaging of Water Transport and Relaxation Processes in the Brain and in Other Soft Tissues


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Depression;Mental Health;Neurosciences;Rare Diseases

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatomy;Anisotropy;Antimitotic Agents;Area;Attention;Axon;Basal Cell;Biological;Biophysical Process;Biophysics;Blood flow;blood oxygen level dependent;Brain;Brain region;Categories;Cell Death;Cell division;cell growth;Cell Line;Cell membrane;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Clinical;clinical application;Clinical Treatment;Complex;Coupled;Data;Data Compression;daughter cell;density;Deposition;Depressed mood;deprivation;Development;Devices;Diffusion;Diffusion Magnetic Resonance Imaging;Electric Conductivity;electric field;Electrodes;Electromagnetic Fields;Electromagnetics;Elements;Environment;Epilepsy;Exhibits;experimental study;Exudate;falls;fluid flow;Frequencies;Functional Magnetic Resonance Imaging;Glioblastoma;Glucose;Goals;Heterogeneity;Hot Spot;improved;In Situ;In Vitro;in vivo;insight;instrument;interest;Ions;Knowledge;Length;Link;Location;magnetic field;Magnetic Resonance Imaging;Magnetism;Major Depressive Disorder;Malignant neoplasm of brain;Maps;Measurable;Measurement;Measures;Membrane;Methodology;Methods;Microscopic;Microscopy;Migraine;Mitotic spindle;Modeling;Motion;Movement;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;neoplastic cell;Nervous System;Nervous System Physiology;neural;neural stimulation;Neurologic;Neurons;Neurosciences;new technology;novel;Organelles;Organism;Osmotic Pressure;Oxygen;Parents;Pattern;Phase Transition;Physics;Physiology;Population;Process;Proxy;Publishing;Pump;Relaxation;Reporter;Research;Research Activity;response;Safety;Scalp structure;Signal Transduction;Slice;sound;Stimulus;Stream;Stroke;Structure;System;Techniques;Temperature;Testing;Theoretical Studies;theories;Therapeutic;Therapeutic Uses;three-dimensional modeling;Time;tissue culture;Tissues;Transcranial magnetic stimulation;Transport Process;Visit;Water;water flow;Water Movements;water testing;Work

PROJECT_TITLE: Transport Processes and Nervous System Function


PROJECT_TERMS: Animals;blastema;Blood Cells;Blood Vessels;Brain;Caenorhabditis elegans;Cell Cycle;cell regeneration;Cell Separation;cell type;Cells;Darkness;Development;DNA;DNA Methylation;Drosophila genus;Endothelium;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenetic silencing;epigenome;Evolution;Eye;Eye Development;Fatty acid glycerol esters;fatty liver disease;Fishes;Follow-Up Studies;Food;Food deprivation (experimental);Fresh Water;Gametogenesis;Gases;Gene Activation;Gene Expression Regulation;Genes;Genetic Screening;Genome;Goals;Hair Cells;Heart;Hematopoietic stem cells;Histones;Human;Hypoxia;insight;Invertebrates;Laboratories;Liver;Maintenance;Maps;memory retention;Metabolic;Mexican;Mexico;model organism;Molecular;Monitor;multipotent cell;Mus;Muscle;mutant;Mutate;Natural regeneration;Neurons;novel;Nucleotides;Organ;Pathway interactions;Pattern;Phenotype;Pigmentation physiologic function;Pigments;Play;Population;Proteins;reduced muscle mass;regeneration model;Regulation;Reporter;Reporter Genes;Reporting;Reproduction;Role;Salamander;Sampling;Sensory Hair;single-cell RNA sequencing;stem;Surface;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomic profiling;Transgenic Organisms;Vertebrates;Work;wound healing;Zebrafish

PROJECT_TITLE: Epigenetics of Development


PROJECT_TERMS: Architecture;Area;Atlases;Axon;Biophysics;Brain;Brain imaging;BRAIN initiative;brain tissue;Callithrix;Clinical;clinical implementation;clinical translation;connectome;Data;Development;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Ensure;Experimental Designs;Family;Fractals;Funding;General Hospitals;Goals;Grant;Heterogeneity;histological image;Human;Image;image processing;Imaging Device;in vivo;Infrastructure;Intramural Research Program;invention;Laboratories;Macaca;magnetic field;Magnetic Resonance Imaging;mathematical model;Mathematics;Measures;Methodology;Methods;Microscopic;migration;Modeling;Morphologic artifacts;Morphology;National Institute of Child Health and Human Development;Noise;novel;Performance;physical model;Physiologic pulse;processing speed;prototype;Research;research clinical testing;Research Personnel;Resolution;Role;Scanning;Side;Signal Transduction;Structure;Testing;Time;Tissues;Translating;United States National Institutes of Health;volunteer;Water;water diffusion

PROJECT_TITLE: Development of the Connectome II MRI Scanner


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PI_NAMEs: MATTHIES, DOREEN  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Aging;Amino Acids;autism spectrum disorder;Binding;Binding Sites;Biochemical;Biochemistry;Biogenesis;Biological;biophysical techniques;Cells;Child;Child Development;Citric Acid Cycle;Collaborations;combat;Complex;computer studies;Controlled Environment;Couples;COVID-19;COVID-19 pandemic;Cryo-electron tomography;Cryoelectron Microscopy;Cytochrome bc1 Complex;cytochrome c;Data;Detergents;Development;Dissociation;drug development;Electron Microscopy;Electron Transport;Electron Transport Complex III;Environment;extracellular vesicles;Fumarates;Goals;Home;Homologous Gene;Human;human disease;Hydroquinones;Individual;Inner mitochondrial membrane;Investigation;Ions;Lead;Length;light microscopy;lipid transport;Lipids;Liposomes;Magnesium;magnesium ion;Membrane;Membrane Lipids;Membrane Proteins;Membrane Structure and Function;Methods;Micelles;Microscopy;Mitochondria;mitochondrial membrane;Mitochondrial Respiratory Chain Deficiencies;Molecular Biology;Morphology;mutant;Mutate;N-terminal;nanodisk;Oxidative Phosphorylation;particle;Peptides;Pharmaceutical Preparations;Polymers;Primary Prevention;Process;programs;protein complex;Protein Conformation;protein function;protein structure;Proteins;Protomer;Protons;Reaction;receptor;Regulation;Research;Resolution;Respiratory Chain;SARS-CoV-2 spike protein;Scanning Electron Microscopy;Scientist;Shapes;Sodium Chloride;Specificity;structural biology;Structure;Succinate Dehydrogenase;Succinates;Techniques;Testing;Therapeutic;Tissues;Transport Process;tumorigenesis;ubiquinol;Ubiquinone;vaccine development;Vaccines;Variant;Vesicle;vesicle transport;Viral;viral entry inhibitor;Virus;Virus-like particle

PROJECT_TITLE: Towards high-resolution structural biology of membrane protein complexes in their native lipid environment


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Lymphatic Research;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

PI_NAMEs: SHEPPARD, SARAH  (contact)

PROJECT_TERMS: 3-Dimensional;advocacy organizations;Affect;Ascites;Biological Models;Blood;Blood Vessels;bone;cell free DNA;Cell Separation;Cessation of life;Clinical Trials;cohort;Complex;Conduct Clinical Trials;Data;deep sequencing;Dermal;Development;Diagnostic Procedure;Disease;disease phenotype;DNA;Drug Screening;Dysplasia;Edema;efficacious treatment;Etiology;Family;Fertility;Future;Genes;Genetic;genetic disorder diagnosis;genetic manipulation;genetic variant;Genomics;Genotype;Goals;Gorham-Stout disease;Guidelines;Human;Image;improved;in vivo;Individual;inhibitor;KRAS2 gene;Larva;Lesion;Life;liquid biopsy;Lymph;Lymphangiomatosis;Lymphatic;lymphatic development;Lymphatic Diseases;Lymphatic Endothelial Cells;Lymphatic Endothelium;lymphatic malformations;lymphatic vasculature;Lymphedema;Lymphocyte;malformation;MAP Kinase Gene;Medical;Medication Management;MEK inhibition;Modeling;Molecular;Molecular Diagnosis;molecular targeted therapies;Monitor;Morbidity - disease rate;mosaic variant;Mosaicism;Natural History;novel;novel therapeutics;Organoids;Outcome;Parents;Participant;Pathogenicity;Pathway interactions;Patients;PECAM1 gene;Pericardial effusion;Pharmaceutical Preparations;Phenotype;Phosphorylation;PIK3CA gene;Plasma;Pleural effusion disorder;precision medicine;preclinical study;prenatal;prognostication;prospective;Rare Diseases;recruit;Research;screening;Signal Transduction;Somatic Mutation;Symptoms;targeted treatment;Technology;Tissue Sample;Translational Research;tumor;Variant;Venous;Work;Zebrafish

PROJECT_TITLE: Cellular and Molecular Mechanisms of Vascular Malformations


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

PROJECT_TERMS: adipokines;adverse pregnancy outcome;American;biomarker panel;Body fat;cardiometabolism;Clinical Endocrinology;Clinical Nutrition;Data;Development;Diabetes Mellitus;Endocrinology;Epidemiology;Etiology;Fetal Growth;First Pregnancy Trimester;Functional disorder;Future;Gestational Diabetes;Glycosylated hemoglobin A;Growth Factor;High Risk Woman;improved;insight;Insulin;International;Investigation;iron metabolism;Journals;Length;Life Style;Lipids;longitudinal, prospective study;Metabolic;metabolomics;Nested Case-Control Study;Nutrient;Nutritional;Obesity;Outcome;Pathway interactions;Physiological;Pregnancy;Pregnant Women;Reporting;Research;Risk;Risk Factors;Role;Saturated Fatty Acids;screening;telomere;Thyroid Function Tests;Thyroid Gland;Vitamin D;Woman;Work

PROJECT_TITLE: GDM sub-study of Fetal Growth Studies


PROJECT_TERMS: Agreement;Bayesian Analysis;Bayesian Modeling;Chemicals;Data Analyses;Data Set;Development;diagnostic accuracy;epidemiology study;Goals;Measurement;Methodology;Methods;Modeling;multidimensional data;National Institute of Child Health and Human Development;novel;Perinatal Epidemiology;prenatal;public health research;reproductive development;Statistical Methods;United States National Institutes of Health

PROJECT_TITLE: Statistical methodology development for reproductive and perinatal epidemiology


NIH_SPENDING_CATS: Clinical Research

PROJECT_TERMS: Collaborations;data cleaning;Data Collection;Device or Instrument Development;Epidemiologist;Goals;Information Dissemination;National Institute of Child Health and Human Development;Patient Recruitments;Public Health;Research Design;Statistical Data Interpretation;United States National Institutes of Health

PROJECT_TITLE: General collaborations


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Congenital Structural Anomalies;Genetics;Lung;Neonatal Respiratory Distress;Osteogenesis Imperfecta;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LEIKIN, SERGEY  (contact)

PROJECT_TERMS: 1 year old;Acute;Acute Respiratory Distress Syndrome;Affect;Animals;Biological Assay;Birth;Bone Surface;Breathing;Cells;Collaborations;Collagen;Computational algorithm;Connective Tissue;Data Analyses;Deformity;Deposition;Development;Diagnostic;diagnostic tool;Disease;Distress;Early Intervention;Embryo;Evaluation;experimental analysis;Extracellular Matrix;fetal;Fiber;Fluorescent in Situ Hybridization;Fracture;Frequencies;Functional Imaging;Genomics;Goals;Histologic;Histology;Image;imaging approach;imaging modality;Immunofluorescence Immunologic;improved;In Situ;in utero;Knock-out;Life;Lung;Measures;Messenger RNA;Methodology;Methods;microscopic imaging;Microscopy;Modality;mouse model;Movement;Multimodal Imaging;multimodality;Mus;Neonatal;Neonatal lung;neonate;Newborn Infant;Osteoblasts;Osteogenesis Imperfecta;Pathology;Personal Satisfaction;Pregnancy;Prevention;progenitor;Protocols documentation;Publications;pulmonary hypoplasia;Pulmonary Pathology;Resolution;rib bone structure;RNA;Sampling;skeletal dysplasia;spectroscopic imaging;Spectrum Analysis;structural imaging;substantia spongiosa;Technology;Testing;Tissue Fixation;Tissue imaging;Tissues;transcriptome;transcriptomics;ultrasound;Work

PROJECT_TITLE: Imaging structural and functional relationships between cells and ECM


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Fetal Tissue;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SIDRANSKY, ELLEN  (contact)

PROJECT_TERMS: Affect;alpha synuclein;Alternative Therapies;American;Animals;Ashkenazim;Astrocytes;base;Basic Science;bench to bedside;Biochemical;Biological Assay;Brain;Cell Differentiation process;Cell model;Cell Physiology;Cells;Cellular biology;Cessation of life;Chemicals;Clinical;Clinical Data;clinical phenotype;Clinical Protocols;Clinical Research;Clinical Sciences;cohort;Collaborations;Complex;cost;Defect;Development;Disease;Disease Progression;DNA;dopaminergic neuron;drug development;Engineering;enzyme deficiency;enzyme replacement therapy;Enzymes;Evaluation;experience;Family;Family Study;Fibroblasts;Gaucher Disease;gene therapy;Genes;Genetic Diseases;genetic risk factor;Genetic Screening;Genetic study;genome sequencing;Genomic approach;Genotype;Germ Lines;glucosylceramidase;Glycolipids;Goals;Hereditary Disease;Heterogeneity;Human;Human Genetics;improved;in utero;Incidence;Individual;induced pluripotent stem cell;Inherited;insight;Intravenous infusion procedures;Laboratories;Lead;Lewy Body Disease;Libraries;Link;lipidomics;Lipids;Lysosomal Storage Diseases;Lysosomes;Macrophage;Mendelian disorder;Metabolic;metabolomics;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutation;National Center for Advancing Translational Sciences;Natural History;Nerve Degeneration;Neuronal Differentiation;Neurons;neuropathology;new technology;next generation sequencing;novel therapeutic intervention;novel therapeutics;Octogenarian;Odds Ratio;Other Genetics;overexpression;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;Prevalence;Proteomics;prototype;rare genetic disorder;Relative Risks;Research;research clinical testing;Research Personnel;Risk;Risk Factors;RNA;Role;Sampling;screening;serial imaging;Siblings;small molecule;Solid;Sphingolipidoses;Study Subject;Techniques;Testing;therapeutic evaluation;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;translational approach;Uniparental Disomy;whole genome;Work

PROJECT_TITLE: Genetic and clinical studies of Gaucher disease and other lysosomal disorders


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lupus;Racial and Ethnic Minority Health Research

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PI_NAMEs: CRISWELL, LINDSEY  (contact)

PROJECT_TERMS: Adenine;Age;Anti-malarials;apoAI regulatory protein-1;Asian;Asian ancestry;Asian population;autoencoder;Autoimmune Diseases;autoimmune rheumatologic disease;Autoimmunity;Award;B-Lymphocytes;bead chip;biobank;Biologic Characteristic;Biological;Biopsy;Biopsy Specimen;Blood;Blood Cells;California;Candidate Disease Gene;cell type;Cells;Chemical Exposure;Chemicals;climate change;climate-related health;Clinical;clinical care;clinical center;Clinical Data;clinical phenotype;Code;cohort;Cohort Studies;Collaborations;comparison control;Coupled;Data;Databases;design;Development;Diagnosis;differential expression;Disease;Disease remission;disorder risk;DNA;DNA Integration;DNA Methylation;East Asian;Enrollment;environmental chemical;Environmental Exposure;Environmental Risk Factor;epidemiology study;Epigenetic Process;epigenetic profiling;epigenome;Epithelial Cells;Estrogen deficiency;Eugenol;European;exome sequencing;experience;Family;Family member;Fibroblasts;Flare;follow-up;Frequencies;Funding;Gene Expression Regulation;Gene set enrichment analysis;Genes;Genetic;genetic architecture;genetic epidemiology;Genetic Research;Genetic study;genetic variant;genome wide association study;genome-wide;Genomics;Gland;Glutamic Acid;Goals;gut microbiota;Health;Hypermethylation;Immune;improved;Individual;Inflammation;Interferons;International;Laboratories;Lacrimal gland structure;large datasets;Leadership;Link;Lipid Peroxidation;Liquid Chromatography;Longitudinal Studies;Lupus;Lupus Nephritis;Manuscripts;Mass Spectrum Analysis;Measures;metabolome;metabolomics;Methods;Methylation;Modeling;Modification;mouse model;multi-ethnic;multi-racial;National Human Genome Research Institute;National Institute of Dental and Craniofacial Research;National Institute of Environmental Health Sciences;Not Hispanic or Latino;Oleic Acids;Onset of illness;Outcome;Oxidative Stress;Participant;Pathogenesis;Pathway interactions;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Peru;Pharmaceutical Preparations;Phenotype;phthalates;Physicians;Plasma;Production;programs;Protocols documentation;Publishing;Race;rare variant;Rattus;recruit;Registries;repository;Research;Research Project Grants;Rheumatoid Arthritis;rheumatologist;Risk;Saliva;Salivary Glands;sample collection;Sampling;San Francisco;Serum;sex;Site;Sjogren's Syndrome;small molecule;Smoke;sociodemographic factors;Statistical Methods;Subgroup;Systemic Lupus Erythematosus;targeted treatment;Testing;Time;Tissues;United States National Institutes of Health;Universities;Variant;Visit;Whole Blood;Wildfire

PROJECT_TITLE: Genomic Studies of Autoimmune Rheumatic Disease


ACTIVITY: ZIC

ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: FLEGEL, WILLY  (contact)

PROJECT_TERMS: Address;blood group;Blood typing procedure;clinical center;Collaborations;editorial;Erythrocytes;Genotype;Goals;Immunology;Institution;International;Laboratories;Molecular Genetics;patient safety;Publications;Published Comment;Publishing;Reporting;Research;Resources;Serology;Services;Summary Reports;transfusion medicine;United States National Institutes of Health

PROJECT_TITLE: Laboratory Services Section, Department of Transfusion Medicine Core Report


PI_NAMEs: WEST-MITCHELL, KAMILLE  (contact)

PROJECT_TERMS: Aliquot;Blood;Blood Component Removal;Blood Donations;Blood donor;clinical center;Code;Collection;Compensation;Consent Forms;Counseling;design;Education;Electronics;Eligibility Determination;Enrollment;healthy volunteer;Human Subject Research;In Vitro;in vivo;Informed Consent;Institutional Review Boards;Laboratories;Link;meetings;Monitor;National Institute of Allergy and Infectious Disease;Nature;Online Systems;Procedures;Process;Protocols documentation;recruit;Research;Research Personnel;Resources;Risk;Safety;Sampling;Schedule;Study Subject;Techniques;transfusion medicine;United States National Institutes of Health;Venous blood sampling;Whole Blood

PROJECT_TITLE: Collection and Distribution of Blood Components from Healthy Donors for In Vitro Use


ACTIVITY: ZIH

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PI_NAMEs: IDRISS, ASMA  (contact)

PROJECT_TERMS: Annual Reports;Appointment;Area;biobank;Biological;Businesses;Capital;Cardiac;Certification;Clinical;clinical application;clinical center;Clinical Data;Clinical Informatics;Clinical Medicine;Clinical Trials;Clinical Trials Database;cloud platform;Collaborations;Collection;Communication;Communities;Computer software;Computers;Custom;Data;data integration;Data Mart;Data Reporting;Databases;design;Development;Development Plans;Documentation;Education;Eligibility Determination;Environment;Equipment;Event;Expenditure;Feedback;Funding;Health;Human Resources;improved;Individual;Informatics;informatics tool;Information Systems;Information Technology;Infrastructure;instrument;Internet;Intramural Research;Intranet;Journals;Laboratories;laboratory experience;Libraries;Licensing;Magnetic Resonance;Maintenance;Medical;Mentors;migration;Modernization;Monitor;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;National Institute of Mental Health;Natural History;Newsletter;occupational health/safety;Office of Administrative Management;operation;Patient Self-Report;Postbaccalaureate;posters;Process;Professional counselor;Progress Reports;Protocols documentation;Publications;Publishing;quality assurance;Recovery Support;Reporting;Research;Research Personnel;Research Project Grants;response;Running;Safety;Sampling;satisfaction;Secure;service programs;Services;Site;software development;Surveys;System;Time;Training;Training Programs;translational medicine;Translational Research;Travel;United States National Institutes of Health;Update;Validation;Visualization;web services;web site;Work

PROJECT_TITLE: Clinical & Research Informatics


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: OVERALL – PROJECT NARRATIVE The University of Hawai‘i Cancer Center (UHCC) is dedicated to pioneering cancer research tailored to the distinct ethnic and cultural characteristics of Hawai‘i and the Pacific. Through a blend of innovative research, clinical trials, and robust community outreach and engagement, UHCC prioritizes underserved groups like Native Hawaiians and Pacific Islanders. Supported by many stakeholders, including State and Federal sponsors, our mission is to transform cancer care, emphasizing diversity, equity, and inclusion, ensuring Hawai‘i and the Pacific lead in globally impactful cancer discoveries.

PI_NAMEs: UENO, NAOTO T. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Aging;Analytical Biochemistry;anti-cancer research;Area;Asian Americans;authority;Automobile Driving;base;Basic Cancer Research;Biodiversity;Bioinformatics;Biological;Biometry;Body Composition;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Etiology;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer research center director;Cancer Research Center of Hawaii;cancer risk;cancer therapy;Catchment Area;Characteristics;Clinic;Clinical Investigator;Clinical Research;Clinical Trials;clinically relevant;cohort;Collaborations;collaborative approach;Communities;community engagement;Community Networks;Community Outreach;community setting;Cultural Characteristics;culturally appropriate intervention;Death Rate;Dedications;diversity and equity;Education;Ensure;Environment;equity, diversity, and inclusion;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;Etiology;experience;Extramural Activities;Fostering;Funding;Genetic;Genomics;Geography;Goals;Growth;Guam;Hawaii;health disparity;health equity;health equity promotion;Health Policy;Health Professional;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;inter-institutional;Intervention;Lead;Leadership;Life Style;Location;Malignant Neoplasms;Medical;member;Mission;Monitor;multi-ethnic;National Cancer Institute;Native Hawaiian or Other Pacific Islander;Network-based;next generation;novel;novel strategies;nutrition;Outcome;Pacific Islands;participant enrollment;Patient Care;patient population;Patient Representative;Peer Review;Phase;Policies;Population;Population Heterogeneity;Population Programs;Population Sciences;Positioning Attribute;Prevention;Prevention approach;programs;Provider;Public Health;Public Policy;Publications;Publishing;Race;racial diversity;racial minority;racial population;Recording of previous events;Research;Research Activity;Research Infrastructure;Research Personnel;Research Priority;Research Training;Resource Sharing;Rural;Screening for cancer;Societies;socioeconomics;Students;Therapeutic;Traditional Medicine;Training;Translating;translational cancer research;Translations;Travel;treatment response;underserved area;Underserved Population;Universities;Vision;Vulnerable Populations;Work

PROJECT_TITLE: University of Hawaii Cancer Center CCSG

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MARTIN, CLIFFORD C (contact)

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Automobile Driving;Award;Budgets;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer education;Clinical Trials;Collaborations;Communication;Communication Methods;community engagement;Community Outreach;Data Reporting;Dedications;Development;diversity and equity;diversity and inclusion;Education;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;experience;Extramural Activities;fighting;Fostering;Funding;Grant;Hawaii;Hospitals;Human Resources;human subject;Information Technology;Infrastructure;innovation;Institution;Lead;Leadership;Malignant Neoplasms;meetings;member;Mission;Monitor;National Cancer Institute;operation;Outcome;outreach;Patient Care;Pilot Projects;Play;Policies;Population Sciences;Positioning Attribute;Price;Process;programs;Publications;Quality Control;Research;research facility;Research Infrastructure;Research Support;Research Training;Resource Sharing;Resources;Role;satisfaction;Source;Strategic Planning;Strategic vision;Stream;success;symposium;Training and Education;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Cancer Center Administration


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: NORTHSIDE HOSPITAL ATLANTA

ORG_STATE: GA

PHR: Project Narrative GA NCORP Community Site addresses two important challenges in US public health: expanding cancer research to a broader population and including underserved populations in cancer research. Advances in clinical care and scientific discovery are not currently equally available to all races and ethnic groups. GA NCORP will continue to analyze data to identify areas for potential improvement, identify proven best practices, and utilize the expertise of research network affiliates and disparities experts to develop and enhance efforts to achieve equitable access to clinical trials.

PI_NAMEs: CANTUARIA, GUILHERME  (contact);HENRY, LEONARD R.

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;Advocate;Aftercare;anti-cancer research;Area;base;biobank;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Hospital;Cancer Patient;care delivery;Caring;clinical care;Clinical Research;clinical trial enrollment;Clinical Trials;clinically significant;Collaborations;Collection;Communities;Community Clinical Oncology Program;community involvement;Contracts;control trial;Data;Development;Diagnosis;Disparity;Education;Elderly;Eligibility Determination;Enrollment;Equity;ethnic minority;Ethnic Population;evidence base;Evidence based practice;gender minority;Genetic Counseling;Goals;Guidelines;health care service organization;human subject;Image;imaging study;Improve Access;improved;Individual;Infrastructure;insight;Institution;Leadership;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;medical specialist;Monitor;National Cancer Institute;National Comprehensive Cancer Network;Newly Diagnosed;Oncologist;Oncology;Participant;participant enrollment;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Population;Prevention;Prevention trial;programs;protocol development;Protocols documentation;Public Health;Quality of Care;Quality of life;racial minority;racial population;Recording of previous events;Research;Research Design;Research Personnel;research study;Resources;Risk;rural dwellers;screening;Sexual and Gender Minorities;Side;simulation;Site;Structure;Study Subject;symptom management;treatment trial;Underrepresented Populations;Underserved Population;young adult

PROJECT_TITLE: Georgia NCI Community Oncology Research Program (GA NCORP)


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Pregnancy;Prevention;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The UCSF Discovering cancer Risks from Environmental exposures And Maternal/child health (DREAM) cohort is designed to fill current gaps in knowledge about the role of environmental exposures in cancer etiology by engaging with a diverse population of pregnant women. Through focusing on this critical, but understudied window of exposure, our study will contribute to an enhanced understanding of the relationships between multiple exposures to environmental contaminants and intermediate cancer risk biomarkers. In the long term, results can support earlier identification of risk factors, allowing for more effective prevention of environmentally mediated cancers.

PI_NAMEs: REYNOLDS, PEGGY  (contact);WOODRUFF, TRACEY J.

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: 4 year old;Address;Air;Area;Aromatic Amines;Biological Assay;Biological Markers;Biological Monitoring;Blood;California;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer risk;Carcinogens;cell immortalization;Characteristics;Chemicals;Child;Chronic;Clinical;cohort;Collaborations;Collection;Common Data Element;Communities;community engagement;consumer product;Data;Data Collection;data management;design;Development;Disparity;DNA Damage;Early identification;Endocrine Disruptors;Enrollment;Environment;environment related cancer;Environmental Carcinogens;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Risk Factor;epidemiology study;ethnic diversity;Ethnic Origin;experience;Exposure to;Feedback;flexibility;Funding;Future;Geographic Information Systems;Geography;Hair;Health;Hormonal;Hormones;Hospitals;Immune response;immunoregulation;Incidence;Infant;Inflammation;information system analysis;Infrastructure;innovation;insight;Interdisciplinary Study;Knowledge;Laboratories;Life;Link;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;mammary;Maternal and Child Health;Measures;Mediating;Medical;Methods;Modification;Morphology;Mothers;Nail plate;Neighborhoods;neoplasm registry;offspring;Outcome;Oxidative Stress;Participant;Patient Recruitments;Pesticides;Phase;phthalates;Physiological;Plasticizers;pollutant;Poly-fluoroalkyl substances;population based;population health;Population Heterogeneity;Positioning Attribute;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;Prevention;Process;programs;Questionnaires;racial diversity;receptor;Recording of previous events;Records;recruit;reproductive epidemiology;Research;research and development;research data dissemination;Research Priority;Risk;Risk Factors;Role;Saliva;Sampling;San Francisco;Science;Second Pregnancy Trimester;Site;Surveys;System;Testing;Translations;Urine;Water;Woman;Work

PROJECT_TITLE: DREAM: Discovering cancer Risks from Environmental contaminants And Maternal/child health


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Administrative Coordination;Adolescent;adolescent woman;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Area;Biological Assay;Child;clinical care;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;co-infection;cohort;Conduct Clinical Trials;Contractor;Counseling;design;detection assay;detection limit;Diagnosis;Discipline of Nursing;Disease;Disease remission;Drug Kinetics;Education;Enrollment;Ensure;Epidemiology;Equipment;experience;Formulation;Goals;high risk;HIV;HIV Infections;HIV therapy;HIV/AIDS;Human;Human Resources;human subject;Immunologics;in utero;Infant;infant infection;Inpatients;Institution;Institutional Review Boards;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Laboratories;laboratory facility;Laboratory Technicians;Leadership;Longitudinal Studies;Mediation;Medical;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Natural History;neonate;Neuropsychology;Nevirapine;Nucleosides;Office for Human Research Protections;Outpatients;Participant;participant enrollment;patient population;Patients;Pharmaceutical Preparations;Pharmacists;pharmacologic;Phase;Postpartum Women;Pregnant Women;Prevention;Protocols documentation;Qualifying;recruit;Regulation;Research;Research Activity;Research Personnel;research study;Research Subjects;Reverse Transcriptase Inhibitors;RNA;safety assessment;Sampling;Services;Site;Social Work;Specific qualifier value;Specimen;Specimen Handling;Symptoms;Testing;testing services;Treatment Protocols;United States;Vertical Disease Transmission;web site;Work

PROJECT_TITLE: P1115 - VERY EARLY INTENSIVE TREATMENT OF HIV-INFECTED INFANTS TO ACHIEVE HIV REMISSION: A PHASE I/II PROOF OF CONCEPT STUDY


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: MYERS, JEFFREY NICHOLAS (contact);SANDULACHE, VLAD C

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Administrative Coordination;Administrator;Advisory Committees;Affect;Agreement;Basic Science;Bioinformatics;Biological Specimen Banks;Cisplatin;Clinical Research;Collaborations;Communication;Communities;Consult;Consultations;cost effective;Data Coordinating Center;data integrity;data management;data quality;Decision Making;Dedications;design;Discipline;Drug resistance;Employment;Ensure;Equilibrium;Event;experience;Future;Goals;Grant;Head and Neck Cancer;Human Resources;Institution;interdisciplinary approach;Leadership;lectures;meetings;Modeling;Monitor;multidisciplinary;Outcome;Performance;Periodicals;Pharmacotherapy;pre-clinical;pre-clinical research;Preparation;Publications;Qualifying;quality assurance;Quality Control;Recommendation;Regulation;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Resistance;Resources;Rest;Schedule;Structure;success;symposium;System;Training;Translational Research;tumor;Work


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

ORG_STATE: MA

PI_NAMEs: ESCALERA, LIYA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;American;Area;behavioral and social science;Behavioral Sciences;Black Populations;Boston;Cancer Center;cancer health disparity;career;career development;Color;Communication;Communities;COVID-19 pandemic;Dana-Farber Cancer Institute;design;Development;Disabled Persons;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;Education;education research;Educational Status;Enrollment;Ethnic Population;evidence base;experience;Faculty;Fellowship;Fostering;Genomics;Graduate Degree;graduate school;graduate student;Grant;Group Affiliation;Growth;Health;health communication;Health Disparities Research;health disparity;Healthcare;improved;Individual;Infrastructure;innovation;Institutional Racism;interest;Intervention;Investments;Knowledge;Latinx;Low Income Population;Malignant Neoplasms;Manuscripts;Massachusetts;Mentors;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;outreach;Peer Review;personalized cancer therapy;Phase;physical science;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Publications;racial population;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;skills;Students;success;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Data Science;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This research infrastructure project will harmonize and merge multiple data sets needed to answer new and complex questions about the aging trajectories and health of diverse populations during the universal process of aging. This project will explore the interactions of shared risk factors across levels (patient, provider, com- munity, health care system, and society) and domains (biological, behavioral, sociocultural, and physical/ built environments) using state-of-the-art analytic methods. This project is relevant to the National Institute on Ag- ing’s mission to support clinical, social, and economic research on aging.

PI_NAMEs: JARRÍN MONTANER, OLGA F. (contact);LIN, HAIQUN

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Activities of Daily Living;Acute;Advanced Development;Affect;Age;Age Years;Aging;aging process;Air Pollution;Alzheimer's disease related dementia;analytical method;Area;Bathing;Behavioral;Behavioral Mechanisms;beneficiary;Biological;built environment;Cancer Institute of New Jersey;care costs;Caregiver Burden;Caring;Censuses;Chronic;Chronic Kidney Failure;Clinical;Clinical Sciences;cohort;Collaborations;Communities;Complex;cost estimate;COVID-19;COVID-19 diagnosis;Data;data infrastructure;data repository;Data Set;decubitus ulcer;Development;Diabetes Mellitus;Diagnosis;Dimensions;disability;Disparity;Disseminated Malignant Neoplasm;Distal;Documentation;Eating;Economics;Elderly;End stage renal failure;Environmental Exposure;experience;Exposure to;falls;functional decline;functional disability;functional independence;functional status;Geography;Goals;Health;health care availability;health care quality;health determinants;Health Disparities Research;health inequalities;Health Policy;Healthcare;Healthcare Systems;Heart failure;HIV;Home;hospice utilization;human old age (65+);Impaired cognition;improved;Incontinence;Independent Living;indexing;Individual;informal care;infrastructure development;innovation;inpatient service;Institution;Institutional Racism;Institutionalization;Institutionalized Persons;Insurance;interest;Intervention;Kidney Diseases;late life;Life;machine learning algorithm;machine learning method;machine learning prediction algorithm;Maintenance;Maps;Measures;Medicare;Mental Depression;Methodology;Methods;Mission;Modeling;mortality;multiple datasets;National Center for Advancing Translational Sciences;National Institute on Aging;Neighborhoods;New Jersey;older adult;Outcome;outcome prediction;Outcomes Research;Pain;Pathway interactions;patient oriented;patient population;Patients;Pattern;person centered;Persons;Physical Function;Policies;Pollution;Population;Population Heterogeneity;Predictive Factor;premature;Process;Provider;Quality of Care;Recording of previous events;Recovery;Recovery of Function;Recovery Support;repository;Research;Research Infrastructure;Research Personnel;resilience in aging;Resources;respiratory;response;Risk Factors;risk sharing;Science;sex;Shapes;skills;social;social culture;Societies;socioeconomics;Source Code;Sterile coverings;Stroke;Surveys;Syndrome;System;Testing;therapy design;Time;Translational Research;United States National Institutes of Health;Variant;Ventilator;Walking;Work

PROJECT_TITLE: Advanced Development and Utilization of Assembled Aging Trajectory Files from Multiple Datasets

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: CLEMSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Rapid, inexpensive detection of protein biomarkers of disease at the point of care is critical for many clinical purposes but is currently not possible for many important clinical targets. Here, we propose a new detection technique that uses in vitro, protein-based signaling networks incorporating self-amplifying enzymatic pathways that results in biomarker detection platforms with unparalleled sensing capabilities in less than two minutes. While initial detection designs will be applied for the point-of-care detection of Hepatitis C Virus, the detection system can be applied to sense any protein or small molecule biomarker with known binders, and as such could be used as a platform for the detection of many analytes currently unable to be rapidly detected at the point of care.

PI_NAMEs: MAJORS, CATHERINE E. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: adenylate;Adenylate Cyclase;Affinity;Antibodies;antigen binding;Antigens;Base Pairing;Binding;Biological Assay;Biological Markers;Biology;Biosensor;Blood;Blood specimen;Clinical;clinical biomarkers;clinical translation;Clinical Trials;clinically relevant;Collaborations;Communicable Diseases;Complex;Computer Models;Concentration measurement;Cyclic AMP;Cyclic AMP Receptor Protein;design;Detection;detection method;detection platform;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;diagnostic platform;Disease;DNA;enzyme reconstitution;Enzymes;Equipment;Feedback;Fluorescence;Fluorescence Resonance Energy Transfer;Freeze Drying;Future;Goals;Hepatitis C;Hepatitis C virus;Human;Immunoglobulin Fragments;In Vitro;in vivo;innovation;Investigation;lateral flow assay;Modeling;Nature;novel;nucleic acid detection;Output;Pathway interactions;Phase;point of care;point-of-care detection;point-of-care diagnostics;Post-Translational Protein Processing;prevent;protein biomarkers;Proteins;rapid detection;Rapid diagnostics;Reaction;Reader;Recombinants;reconstitution;Reporter;response;Sampling;scaffold;Serum;Signal Transduction;Signaling Protein;Sirolimus;small molecule;System;Tacrolimus Binding Protein 1A;targeted biomarker;Tertiary Protein Structure;Testing;Validation;Work

PROJECT_TITLE: Development of a Novel Split Enzyme Diagnostic Platform for Use at the Point of Care

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE On June 24, 2022, the U.S. Supreme Court ruled to eliminate federal protections for abortion access through the Dobbs v. Jackson Women’s Health decision. Our study will evaluate the evolving, time-sensitive impact of the Dobbs decision on people with childbearing capacity, particularly those with chronic diseases. This project will examine: 1) experiences of people seeking abortion, to understand the immediate and long-term consequences of abortion receipt or denial on health and well-being; 2) experiences of physicians who provide care for people with chronic diseases, to describe ways in which evolving abortion policy affects medical decision-making and practice; and 3) population-level data, to generate new evidence about the impact of abortion policy on clinical outcomes, including severe maternal morbidity and maternal mortality.

PI_NAMEs: TALABI, MEHRET BIRRU (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;adverse pregnancy outcome;Advertising;Affect;Age;Birth;Cardiovascular Diseases;Caring;child bearing;Chronic;Chronic Disease;Clinical;clinical center;clinical practice;Complex;Contraceptive methods;court;Dangerousness;Data;Decision Making;disabled;Discipline of obstetrics;Disease;Drug Prescriptions;Eligibility Determination;Epidemiology;Equity;experience;Family Planning;Female;fetal;Health;health equity;Health Policy;health practice;Health Services;Healthcare;healthy pregnancy;high risk;indexing;Individual;Interview;Legal;Life;Low income;Malignant Neoplasms;Maternal Mortality;Medicaid;Medical;Medicine;multidisciplinary;Outcome;Outcome Assessment;Patient Outcomes Assessments;Patients;person centered;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacy facility;Physicians;Policies;Population;population based;Pregnancy;Pregnancy Outcome;pregnant;Primary Care;Procedures;Public Health;Recommendation;Recording of previous events;recruit;Regulation;Reporting;Reproductive Health;Research;Respondent;Risk;Sampling;search engine;severe maternal morbidity;social;socioeconomics;Surveys;Systemic Lupus Erythematosus;Teratogens;Time;Travel;unintended pregnancy;Women's Health

PROJECT_TITLE: Time-Sensitive Research to Assess the Effects of Reproductive Health Policy on the Health Outcomes of People with Chronic Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-E(56)R]


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: GUTTMACHER INSTITUTE

ORG_STATE: NY

PHR: The landscape of reproductive health care in the United States is in the midst of seismic and rapid shifts; abrupt changes in access to abortion in the US are without precedent in terms of the number of individuals who are affected, the number of states in which there remains substantial uncertainty around abortion policy changes in the near future, and the scale of potential effects on the lives of pregnant people. This project addresses the urgent need to assess the impact of state abortion restrictions on the health of pregnant people, as well as the need for high quality estimates of abortion incidence both within and outside of the formal health care system as these restrictions are implemented. This study will advance the field of abortion measurement by establishing estimation approaches that encompass both facility-based and self-managed procedures and are designed for a context in which the legal status of abortion is hybridized and subject to rapid, ongoing changes, laying the foundation for a new surveillance infrastructure that will be needed for the foreseeable future.

PI_NAMEs: SULLY, ELIZABETH ANNE (contact)

PROJECT_TERMS: abortion;Address;Affect;Bayesian Modeling;Caring;Collection;court;critical period;Data;Data Collection;Decision Making;Dedications;design;Elements;evidence base;experience;Face;Family;Family Planning;flexibility;Foundations;Future;Gestational Age;Health;Health care facility;Health Care Sector;health organization;Healthcare;Healthcare Systems;improved;Incidence;Individual;Infrastructure;innovation;Legal;Legal Status;Link;Measurement;Measures;Methodology;Methods;Morbidity - disease rate;mortality;novel;novel strategies;Outcome;Persons;Phase;Policies;Policy Maker;population health;Population Surveillance;Pregnancy;pregnant;Procedures;programs;Provider;Public Health;Publishing;Reporting;Reproductive Health;Research;Research Personnel;Risk;Safety;Sampling;Self Management;service providers;Societies;Surveys;System;Testing;Travel;Uncertainty;United States;Update;Women's Health

PROJECT_TITLE: The impact of new state restrictions on abortion incidence and safety in the United States


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: Metabolic dysregulation, an important manifestation of inflammation, may hold the key for addressing the growing problem of Early-Onset CRC (EOCRC) (i.e., <50 years), and numerous other obesity-related cancers. The proposed work draws on experience that we have accumulated in working with inflammation, and metabolic dysregulation in particular, in both laboratory animal experiments and human studies and that have contributed many hundreds of papers and thousands of citations to the medical literature over the last 10 years. Results from this work, which meld our wide-ranging experience in transdisciplinary science, have important implications for advancing the science and real, practical implications for addressing cancer-related disparities that have consistently disfavor African Americans, a group that is uniquely metabolically obese (i.e., evince symptoms associated with obesity at lower levels of overall adiposity).

PI_NAMEs: HEBERT, JAMES R (contact);HOFSETH, LORNE J;MURPHY, ELIZABETH ANGELA

PROGRAM_OFFICER_NAME: RISCUTA, GABRIELA

PROJECT_TERMS: 3 year old;Address;adenoma;Adipocytes;adiponectin;Adipose tissue;Adult;African American;African American population;Age Years;American;Animal Experiments;Animals;anti-cancer research;Anti-Inflammatory Agents;Antiinflammatory Effect;associated symptom;Bacteria;Biological Assay;C-reactive protein;Cancer Control;cancer epidemiology;cancer health disparity;Cancer Intervention;Cancer Model;cancer prevention;carcinogenesis;Cells;Child;Chronic;Clinical Trials;Colon Carcinoma;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;Communication;Complement 2;Consumption;cytokine;Diet;dietary;Dietary Intervention;Disparity;early onset colorectal cancer;Enrollment;Epidemiology;epidemiology study;European;experience;experimental study;fecal transplantation;Goals;Grant;gut microbes;gut microbiota;Health;High Fat Diet;high risk;Human;human study;in vivo;Incidence;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Influentials;Infrastructure;Insulin;Insulin Resistance;Insulin-Like Growth Factor I;Interleukin-6;Intervention;Intervention Trial;intestinal barrier;Laboratory Animals;lifestyle intervention;Link;Literature;Macrophage;Malignant Neoplasms;Mediator;Medical;Metabolic;Metabolic dysfunction;microbiome;microbiome signature;microbiota;Modeling;mouse model;Obese Mice;Obesity;Obesity associated cancer;obesity in children;Outcome;Paper;Parents;Pathogenesis;Population;pre-clinical;prevent;programs;protective effect;protective factors;Publishing;Race;racial difference;racial identity;response;Risk;Role;Science;Somatomedins;South Carolina;Study models;System;systemic inflammatory response;Testing;TNF gene;tumorigenesis;Unhealthy Diet;Universities;Work

PROJECT_TITLE: A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: HUMPHREYS, KEITH N.;KORTHUIS, PHILIP TODD (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: addiction;Behavioral;Buprenorphine;California;Caring;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinics and Hospitals;Cluster randomized trial;Collaborations;Data Science;Drug abuse;Drug usage;Drug Use Disorder;Drug user;effectiveness/implementation trial;Electronic Health Record;experience;Future;Goals;Health;Health system;Healthcare;Helping to End Addiction Long-term;Hybrids;Hydromorphone;implementation trial;improved;Infrastructure;Intervention;Managed Care;Medicaid;medication for opioid use disorder;Methadone;methamphetamine use;Methamphetamine use disorder;mHealth;Mirtazapine;novel;Opiate Addiction;Opioid;opioid misuse;Oral;Oregon;peer;peer support;Persons;Pharmaceutical Preparations;Pharmacotherapy;phase III trial;Placebos;Primary Care;Protocols documentation;Public Health;Randomized;Research;Research Personnel;Resources;San Francisco;Science;Services;Site;Speed;success;Supervision;sustained recovery;Telephone;Testing;Training;trial comparing;Trillium;United States National Institutes of Health;Universities;Veterans;Vulnerable Populations


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: FOREIGN JUSTIFICATION The funding opportunity announcement requires that we partner with Latin American/Caribbean countries. We  have chosen the Dominican Republic and Peru to partner with us. Dr. Robinson Ceballo at Via Libre, in Peru  will act as a multi-PI on this grant, Dr. Lenka Kolevic, at Via Libre, in Peru will co-chair Trial 1, and Dr. Yeyce  Donastorg at Instituto Dermatologico Dominicano y Cirugia, in Santo Domingo, Dominican Republic will co-chair Trials 2 and 3.

PI_NAMEs: MADELEINE, MARGARET M (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acetic Acids;Address;Adjuvant;Age;Algorithms;Area;automated visual evaluation;Biological Assay;booster vaccine;cancer prevention;Caribbean region;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cessation of life;Child;Clinical;Clinical Trials;Colposcopy;Communities;Correlative Study;Country;Cytology;design;Detection;Disease;Disproportionately impacts women;Dominican Republic;Dose;Enrollment;experience;Funding Opportunities;girls;Goals;Grant;Health;high risk;HIV;HIV Infections;HPV E7;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Imaging technology;Immune;Immunoprevention;implementation facilitation;Improve Access;improved;improved outcome;Incidence;Infrastructure;International;Latin America;Latin American;Lesion;Licensing;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;new technology;novel;Operative Surgical Procedures;Outcome;overtreatment;Pap smear;Papillomavirus Transforming Protein E6;Participant;Patients;Persons;Peru;point of care;Population;Populations at Risk;premalignant;prevent;Prevention;prevention service;programs;progression risk;Provider;Quality of life;Randomized, Controlled Trials;Recurrence;Regimen;Repeat Surgery;Reproducibility;Research;Resources;response;Risk;Schedule;screening;Sirolimus;Site;standard of care;Testing;Time;treatment strategy;Triage;tumor microenvironment;Vaccination;Vaccines;Visual;Woman;women's diagnosis;Youth

PROJECT_TITLE: Clinical Trials Program