FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Complementary and Integrative Health;Genetics;Human Genome;Immunotherapy;Microbiome

ORG_CITY: Rockville

ORG_NAME: RISE THERAPEUTICS, LLC

ORG_STATE: MD

PHR: Project Narrative The microbiota of cancer patients is correlated with their response to immunotherapy drugs, but the mechanisms of specific commensal bacteria strains have not been elucidated and limit their translation into new therapeutics [7- 14]. We recently discovered that beneficial Enterococci strains express a unique enzyme, Secreted Antigen A (SagA), which generates peptidoglycan fragments to engage immune anti-tumor mechanisms. These exciting findings reveal fundamental microbiota mechanisms in cancer immunotherapy and afford a new opportunity to engineer a novel recombinant probiotic drug to delivery SagA, R-5780, to improve cancer immunotherapy.

PI_NAMEs: FANGER, GARY  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Animals;anti-CTLA4;anti-CTLA4 antibodies;anti-PD-L1;anti-PD-L1 therapy;Antigens;antitumor effect;Bacteria;Biological;Biological Assay;biomarker identification;cancer immunotherapy;Cancer Patient;cancer therapy;Capital;cell bank;cell type;checkpoint therapy;Clinical;Clinical Research;Clinical Trials;commensal bacteria;commercialization;cost;CTLA4 gene;Development;Disease;DNA cassette;Dose;drug development;Drug Kinetics;Drug resistance;Drug Synergism;Effectiveness;Engineered Probiotics;Engineering;Enterococcus;Enterococcus faecium;Enzymes;Food production;Funding;Future;Genetic Engineering;Genome;Goals;Growth;gut microbiome;gut microbiota;Health;Homeostasis;host microbiota;Human;Hydrolase;Immune;Immune checkpoint inhibitor;Immune signaling;Immunologics;Immunomodulators;Immunooncology;Immunotherapy;improved;in vivo;Industry;innovation;interest;Intestines;Investments;Laboratories;lactic acid bacteria;Lactococcus lactis;Lead;lead candidate;Link;Malignant neoplasm of lung;Malignant Neoplasms;manufacturability;manufacture;Mediating;Medical;Metastatic Melanoma;Methodology;microbial;microbiome;microbiota;Modeling;Molecular;Mucous Membrane;Mus;N-Acetylmuramoyl-L-alanine Amidase;novel;novel marker;novel therapeutics;Oral;Oral Administration;Overdose;Pathogenesis;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Pattern recognition receptor;Peptides;Peptidoglycan;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;Positioning Attribute;pre-clinical;prevent;Probiotics;Process;product development;programs;Property;Proteins;Recombinants;Refractory;Renal Carcinoma;Research;research clinical testing;resident commensals;response;scale up;Signal Pathway;Small Business Innovation Research Grant;Solid Neoplasm;Study models;synergism;targeted agent;therapeutic development;Toxicology;Translations;tumor;vaccine delivery;Validation;Vancomycin resistant enterococcus;Work

PROJECT_TITLE: A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(12)B]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Among the more common visually threatening congenital eye defects are anophthalmia (total absence of the globe); microphthalmia (anomalously small eye in the orbit); and coloboma (failure of the closure of the fetal fissure) – collectively referred to as MAC. There have been few if any population-based studies to: 1) describe the proportion of cases due to pathogenic variants in known MAC-related genes; or 2) systematically characterize co-occurring phenotypes in these individuals (herein termed “deep phenotyping”), which could provide insights into the underlying etiologies of these conditions and inform precision medicine efforts. Therefore, objectives of the current study are to 1) better define the MAC phenotype and 2) characterize the role of known and potentially novel pathogenic genetic variants that confer MAC susceptibility.

PI_NAMEs: BROOKS, BRIAN PATRICK;LUPO, PHILIP  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 3-Dimensional;Affect;Anophthalmos;Awareness;Birth;Blindness;Brain imaging;cancer predisposition;Child;Clinical;clinical center;Clinical Management;cohort;Coloboma;Complex;Congenital Abnormality;Consent;Core Facility;Counseling;Defect;Diagnosis;digital imaging;Disease Surveillance;disease-causing mutation;DNA Sequence Alteration;Echocardiography;Eligibility Determination;Epidemiologist;Epidemiology;epidemiology study;Etiology;Evaluation;Eye;Face;Failure;Family;fetal;First Degree Relative;gene panel;Genes;Genetic;genetic epidemiology;Genetic study;genetic testing;genetic variant;Genomics;Genotype;Goals;Hearing;Image;improved;Individual;Informed Consent;insight;Interview;Laboratories;Live Birth;Magnetic Resonance Imaging;malformation;Malignant Childhood Neoplasm;Medical Records;member;Microphthalmos;Monitor;multidisciplinary;National Eye Institute;Neuropsychological Tests;novel;Ocular orbit;ophthalmic examination;Ophthalmologist;Parents;Pathogenicity;Persons;Phenotype;Physical assessment;population based;Population Study;precision medicine;Predisposition;Prevalence;Prevention;Recording of previous events;Registries;Research;Resources;Role;Sampling;Screening for cancer;Series;surveillance strategy;Syndrome;System;Texas;United States National Institutes of Health;Variant;Visual;Vital Status;Work

PROJECT_TITLE: Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children (MAGIC) Study


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The University of Wisconsin-Madison Biotechnology Training Program addresses a critical need to educate scientists and engineers in the effective use of cross-disciplinary approaches to solve important problems in biomedical research. This program provides cutting-edge technical, operational and professional training to a diverse cohort of doctoral students drawn from biological, physical and engineering sciences. Ultimately, the career-long contributions of these trainees as leaders in industry, government service and academia are essential to maintain our national excellence and leadership in the application of biotechnology to demanding and dynamic societal needs.

PI_NAMEs: FOX, BRIAN G (contact);MEYERAND, MARY E.

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Biotechnology;Training Programs

PROJECT_TITLE: Biotechnology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative MRI guidance of cardiac catheterization provides a non-ionizing alternative to X-ray fluoroscopy and can improve soft tissue contrast. Recent advances have increased the availability of MRI-safe devices, but clinical use remains limited due to the relatively poor image quality of single-shot, real-time MRI. In this research, we propose to develop a novel, multi-beat data acquisition and image analysis approach to improve anatomic image quality and device visualization, which we test in silico, in vitro, and in vivo.

PI_NAMEs: CONTIJOCH, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;anatomic imaging;Anatomy;Angioplasty;Area;Arrhythmia;Biopsy;Blood Vessels;Cardiac;Cardiac Catheterization Procedures;Cardiovascular system;Catheterization;Catheters;Child;Childhood;Clinical;Clinical Data;clinical imaging;Complex;Contrast Media;Data;data acquisition;Data Collection;data space;design;Device Designs;Devices;Diagnostic;diagnostic catheterization;Drainage procedure;Evaluation;Event;experience;experimental study;first-in-human;Fluoroscopy;Genetic Complementation Test;Goals;Heart;Heating;hemodynamics;Image;Image Analysis;image guided;image reconstruction;Imaging Device;Imaging Techniques;implantable device;improved;in silico;In Vitro;in vivo;Intervention;Interventional Imaging;Ionizing radiation;Magnetic Resonance Imaging;Measures;Methods;minimally invasive;Motion;Noise;novel;novel strategies;Outcome;patient population;pediatric cardiologist;pediatric patients;Performance;Phase;Positioning Attribute;Predisposition;Procedures;Radiation;real-time images;Research;Resolution;Roentgen Rays;Sampling;Signal Transduction;soft tissue;spatiotemporal;Stenosis;Stents;success;Techniques;Testing;Time;Visual;Visualization;Work

PROJECT_TITLE: Improved MRI guidance of pediatric catheterization via autonomous multi-beat data synthesis

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative This application requests funds to support DVM-PhD dual-degree training in translational biomedical research. Well-trained veterinary scientists bring unique knowledge about comparative biology that significantly contributes to the clinician scientist workforce and aids studies of human health and disease.

PI_NAMEs: AVERY, ANNE C;REGAN, DANIEL PATRICK (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Dual-Degree Medical Scientist Training Program for Veterinarians


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Our center will study how genetic variants impact function by studying their effects in all cell types of 8 mouse tissues. We will measure the expression of genes as well as the activity of regulatory elements in a large number of individual cells from these tissues to build maps of which variants impact the expression of these genes in different cell types. We will also measure the impact of genetic variation on inflammation. Our results will help interpret the impacts of variants on gene function in humans as well as support the design of better mouse models of human disease.

PI_NAMEs: MORTAZAVI, SEYED ALI (contact);WOLD, BARBARA J

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Adult;Adult women;Affect;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease model;Astrocytes;ATAC-seq;Biological Assay;Biology;Blood Cells;Brain;Breathing;Catalogs;Cell Line;Cell Nucleus;cell type;Cells;Chromatin;Chromosome Mapping;Communities;Complex;computational pipelines;Computer Models;design;differential expression;Disease;disease model;Dissociation;Ensure;epigenome;Foundations;Gene Expression;gene function;Genes;Genetic;Genetic Engineering;Genetic study;genetic variant;Genetic Variation;Genome;Genomic approach;genomic variation;Genomics;Health;Height;Human;human disease;Human Genetics;human model;human reference genome;human tissue;Inbred Mouse;Inbreeding;Individual;Inflammation;interest;Joints;Libraries;Life;Link;Macrophage;male;Maps;Measures;member;Mission;Modeling;mouse model;Mouse Strains;Mus;National Human Genome Research Institute;Neurons;Nucleotides;Organ;Organism;Organoids;Persons;Phenotype;pre-clinical;Pre-Clinical Model;Predisposition;programs;promoter;Protein Isoforms;Proteins;Protocols documentation;Quantitative Trait Loci;Recombinants;Regulatory Element;Resolution;Resources;response;Rest;RNA;RNA Splicing;Role;Sampling;Signal Transduction;single cell ATAC-seq;single cell genomics;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;single-cell RNA sequencing;Source;Split-Pool Ligation Transcriptome sequencing;Techniques;Tissue Sample;Tissues;tool;Transcript;transcriptome;transcriptomics;TREM2 gene;United States National Institutes of Health;Variant;Work;XCL1 gene

PROJECT_TITLE: Center for Mouse Genomic Variation at Single Cell Resolution


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: We expect to engineer inorganic virus-like nanoparticles (IVLNs) for delivery of non-capsid small antigens, which not only mimic the structural features of virus peplomer, but also exhibit virus-like function in induction of antigen- specific B cells and durable antibody responses. The IVLNs have broad applications to activate B cell immunity against non-capsid small antigens, such as bacterial toxin to prevent/treat bacterial infection (anthrax or botulinum), oncogenic antigen in prevention/treatment of cancers, and high affinity/specificity antibody production against small molecules and small peptides.

PI_NAMEs: SUN, DUXIN  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Affect;Affinity;Animals;Anthrax disease;anthrax toxin;Antibodies;Antibody Formation;Antibody Response;Antibody Specificity;Antibody titer measurement;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Bacterial Infections;Bacterial Toxins;Binding;botulinum;Botulinum Toxins;cancer therapy;Capsid Proteins;Cells;Clinical;crosslink;density;Development;draining lymph node;Engineering;ERBB2 gene;Exhibits;Haptens;Helper-Inducer T-Lymphocyte;Immunity;Immunization;improved;lymph nodes;Malignant Neoplasms;Memory B-Lymphocyte;mimicry;nanoparticle;nanoparticle delivery;Oncogenic;Pattern;Peptides;Plasma Cells;prevent;Prevention;response;self assembly;small molecule;Specificity;Structure;Structure of germinal center of lymph node;System;Testing;Vaccines;Viral;Virus;virus characteristic;Virus-like particle

PROJECT_TITLE: Virus-Like Nanoparticles for Non-Capsid Antigen Delivery with Virus Structure/Functional Mimicry to Activate B Cell Immunity

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Lung;Lung Cancer;Nanotechnology;Radiation Oncology

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  This project aims to develop an ultrasmall nanoparticle, metal intarcalated carbon dots (M@Cdots, M=Gd, and Bi), to enhance radiotherapy against non–small cell lung cancer (NSCLC). We conjugate neurotensin (NTS) to the surface of M@Cdots to improve tumor specificity. It is expected that with efficient dose enhancement, minimal metal leakage, excellent tumor selectivity, sufficient intratumoral penetration, and efficient renal clearance, NTS-M@Cdots will lead to greatly improved radiation therapy outcomes at the same or even reduced radiation doses while causing minimal systemic toxicities.

PI_NAMEs: LI, ZIBO  (contact);XIE, JIN

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: 18F-fluorothymidine;analog;appropriate dose;Biodistribution;Biological Assay;Cancer Etiology;Cancer Patient;cancer type;Carbon;carcinogenesis;Categories;cell killing;chemoradiation;chemotherapy;Cisplatin;cytotoxicity;Development;Diagnosis;Diameter;Disease;Dose;efficacy study;Elements;Encapsulated;Environment;Esophagitis;Etoposide;Excretory function;Extravasation;Failure;falls;follow-up;Formulation;Gadolinium;Head and Neck Cancer;Hematology;image-guided radiation;improved;In Vitro;in vivo;intercalation;Intravenous;ionization;irradiation;Label;Lead;Ligands;Lobectomy;Lung;Lymph Node Dissections;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Metals;Methodology;Methods;microPET;Modeling;molecular imaging;mortality;Mus;Names;Nanoconjugate;nanoparticle;Neurotensin;Neurotensin Receptors;Newly Diagnosed;Niacinamide;Non-Small-Cell Lung Carcinoma;novel;particle;Patient imaging;patient stratification;Patients;Penetration;Persons;Pharmaceutical Preparations;Positron-Emission Tomography;Procedures;Property;Pulmonary Inflammation;Radiation;Radiation Dose Unit;radiation resistance;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;receptor;Regional Disease;Renal clearance function;Research;research clinical testing;Reticuloendothelial System;Risk;Risk Reduction;Roentgen Rays;scale up;Scheme;Silicon Dioxide;standard care;Structure of parenchyma of lung;Surface;systemic toxicity;targeted delivery;Technology;therapy outcome;Tissues;Toxic effect;Toxicity Tests;Treatment Efficacy;Treatment outcome;tumor;tumor specificity;uptake

PROJECT_TITLE: The development of novel radiation-sensitizer based on ultra-small carbon dots


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project aims to establish the neural mechanisms of intra-individual variability in responding, a robust characteristic of ADHD. We will perform secondary data analyses of three existing datasets, to identify a biological measure of neural processing efficiency and link this measure with both variable responding and underlying network dynamics. The results will help to identify an appropriate biological target for treatment and monitoring strategies in disease states, such as ADHD, where intra-individual response variability interferes with cognition and performance in daily life.

PI_NAMEs: LENARTOWICZ, AGATHA  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adult;Attention;Attention deficit hyperactivity disorder;Back;behavior prediction;Behavioral;behavioral outcome;Biological;Characteristics;Child;Clinical;Clinical Trials;Cognition;Data;Data Analyses;Data Set;density;Development;Diffusion;Disease;Dorsal;Electroencephalography;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Hyperactivity;inattention;indexing;Individual;Individual Differences;individual response;individual variation;innovation;inter-individual variation;interest;Interruption;Life;Link;Measures;Modeling;Monitor;Multimodal Imaging;Nature;neural;neural correlate;neuromechanism;neurophysiology;Noise;Outcome;Pathway Analysis;Performance;Periodicals;Phase;Predictive Value of Tests;Property;Reaction Time;Rest;Sampling;secondary analysis;Signal Transduction;Specificity;statistics;sustained attention;Symptoms;Task Performances;temporal measurement;Testing;theories;Time;Treatment outcome;Visit;Visual;Work

PROJECT_TITLE: The neurophysiological basis of interindividual variability (IIV) in ADHD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative (Public Health Relevance) Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths worldwide and is marked by lipid accumulation within the context of fatty liver disease. This project uses microscopy, biochemistry, and in vivo mouse models to investigate novel lipid droplet trafficking mechanisms influencing tumor growth in hepatocellular carcinoma. Completion of this work will advance our understanding of the role of lipid droplets as potential therapeutic targets against liver cancer.

PI_NAMEs: SCHOTT, MICAH  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acceleration;Acid Lipase;Address;Advisory Committees;Affect;Alcohol consumption;anti-cancer research;Applications Grants;Autophagocytosis;Binding;Biochemistry;Biological;Cancer Biology;cancer cell;Cancer Center;Cancer Etiology;Cancer Model;Catabolism;Cell Energetics;Cell Fractionation;Cell Proliferation;Cells;Cellular biology;Cessation of life;Cirrhosis;clinically relevant;Data;Development;Disease;Docking;Endosomes;Energy Supply;Environment;Enzymes;Exhibits;Fatty Liver;fatty liver disease;Future;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;hepatocellular carcinoma cell line;Hepatocyte;HepG2;Homeostasis;Human;in vivo;in vivo Model;Incidence;Injections;Investigation;Knowledge;Laboratories;lipid metabolism;Lipids;Liver;liver cancer model;Liver diseases;Lysosomes;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;Medical center;Metabolic;Microscopy;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Nebraska;novel;Obesity;Oncogenes;Outcome;Pathway interactions;Patients;Phenotype;Physiology;Play;Primary carcinoma of the liver cells;Process;public health relevance;recruit;Research;Research Project Grants;Risk Factors;Role;Signal Transduction;Sleeping Beauty;Steatohepatitis;superresolution microscopy;Surface;Tail;Testing;Therapeutic;therapeutic target;trafficking;Transposase;tumor;tumor growth;tumorigenesis;Universities;Veins;Vesicle;Work

PROJECT_TITLE: Mechanisms of lipid droplet trafficking in hepatocellular carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(55)R]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: The National Academy of Medicine (NAM) labels chronic pain as one of the most extensive health care issues facing our society with “severe impacts on all aspects of the lives of its sufferers.”1 Pain predominant chronic multisymptom illness (Pain-CMI, e.g., fibromyalgia) is a particularly debilitating and presumptive service connected condition for Veterans who deployed to the Gulf region. Health coaching is an appealing potential approach to improve the disability of Pain-CMI because it is personalized to the Veteran’s unique goals and beliefs about Pain-CMI and it will be widely available as the VA is rolling out health coaching. The goal of this proposal is to understand if health coaching is also efficacious for a complex pain condition, Pain-CMI.

PI_NAMEs: MCANDREW, LISA MARIE (contact)

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adherence;Agreement;Area;Belief;Chronic;chronic pain;chronic painful condition;Clinical;Clinical Trials;clinically significant;Cognitive Therapy;Collaborations;Complex;Congresses;Data;design;Diet;disability;Educational process of instructing;efficacy evaluation;Fibromyalgia;follow-up;Goals;Guidelines;Health;Health Services Accessibility;Healthcare;Impairment;improved;Intervention;Label;Leadership;Life;Mediating;Mediation;Medicine;mind/body;motivational enhancement therapy;Pain;Pain management;Patients;Physical activity;physical symptom;Problem Solving;Provider;Psychotherapy;randomized, clinical trials;Recommendation;remote delivery;Resistance;response;satisfaction;Services;Sleep;social relationships;Societies;Symptoms;uptake;Veterans;whole health;Work

PROJECT_TITLE: Health Coaching for Chronic Multi-symptom Illness

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Vaccine Related

PHR: PROJECT NARRATIVE COVID-19 vaccine hesitancy is higher among rural populations, who have some of the lowest COVID-19 vaccination rates in the nation. Community pharmacists, who are the one of the most trusted and accessible health professionals in rural areas, are well-positioned to provide COVID-19 vaccinations and address vaccine hesitancy in their communities. This project will examine sustainable ways to support rural pharmacists as they implement COVID-19 vaccine hesitancy counseling practices to mitigate the negative impact of COVID-19 and SARS-CoV-2 variants in underserved rural populations.

PI_NAMEs: CARPENTER, DELESHA MILLER (contact);CURRAN, GEOFFREY M

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adoption;Agreement;Ally;Automobile Driving;Budgets;Cessation of life;Charge;Communities;Community Pharmacy;comorbidity;Complex;Cost Analysis;cost effective;Counseling;Country;COVID-19 complications;COVID-19 impact;COVID-19 pandemic;COVID-19 susceptibility;COVID-19 vaccination;COVID-19 vaccine;Data;Data Collection;disparity reduction;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;evidence base;Evidence based practice;Feedback;flu;Goals;Health;health care availability;Health Professional;health professional shortage areas;Healthcare;High Prevalence;Hospitals;Hour;Human Papilloma Virus Vaccination;Human Papillomavirus;implementation facilitation;implementation fidelity;implementation outcomes;implementation science;improved;Individual;Infrastructure;Intervention;Modeling;Monitor;pandemic disease;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Politics;Positioning Attribute;practice-based research network;Primary Care;primary care provider;primary outcome;Research;Resources;Risk;Rural;rural area;Rural Community;rural counties;rural patients;Rural Population;rural underserved;Safety;Sampling;SARS-CoV-2 variant;secondary outcome;Services;severe COVID-19;Social Distance;Source;support tools;System;Telephone;Testing;Time;Training;Travel;Trust;Update;Urban Population;Vaccination;vaccine acceptance;vaccine hesitancy;Vaccines;video coaching;virtual;Walking

PROJECT_TITLE: Addressing COVID 19 Vaccine Hesitancy in Rural Community Pharmacies Reducing Disparities Through an Implementation Science Approach

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The Glycoscience Training Program provides an interdisciplinary training environment for a diverse group of predoctoral students with research interests in carbohydrates, working at the Chemistry-Biology interface. This training program capitalizes on unique research strengths and capabilities in the glycosciences that exist at the University of Georgia. The program will recruit six new T32 trainees per year, and will emphasize scientific rigor, quantitative methods, communication, and other skills that will prepare them for a broad range of career opportunities in research, education, and government.

PI_NAMEs: AMSTER, I JONATHAN;HALTIWANGER, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Grant;pre-doctoral;Training

PROJECT_TITLE: T32 Predoctoral training grant in Glycosciences

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Out-of-hospital cardiac arrest (OHCA) is a leading cause of mortality in the United States and around the world. Although OHCA occurs via heterogeneous mechanisms and manifests a time-dependent pathophysiology, the current resuscitation protocol uses a singular, one-size-fits-all approach that belies the underlying dynamic physiology within and across OHCA patients. The current project will evaluate innovative approaches of artificial intelligence that asses continuous bio-signals from the defibrillator monitor to gauge patient-specific physiologic status, which in turn may help target differential treatments that align specific therapy with the individual patient’s acute OHCA physiology, and ultimately improve resuscitation and public health.

PI_NAMEs: REA, THOMAS D (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Accounting;Acute;Adult;Affect;Algorithms;Anti-Arrhythmia Agents;Artificial Intelligence;artificial intelligence method;blind;Blinded;Carbon Dioxide;Caring;Cessation of life;Chest;Childhood;Clinical;clinical application;clinical phenotype;computerized data processing;data resource;Decision Making;Defibrillators;digital;Dose;Electric Countershock;electric impedance;Electrocardiogram;Experimental Models;Functional disorder;Goals;Heterogeneity;Hypoxia;Impedance Cardiography;improved;Individual;individual patient;individualized medicine;innovation;Interruption;Investigation;Measures;Monitor;Morphologic artifacts;Morphology;mortality;multidisciplinary;Myocardial Ischemia;novel strategies;optimal treatments;out-of-hospital cardiac arrest;Outcome;Patients;Performance;Perfusion;personalized approach;Phenotype;Physiologic pulse;Physiological;Physiology;Population;precision medicine;prevent;Process;Prognosis;prognostic;prospective;Protocols documentation;Provider;Public Health;randomized trial;Research;Resuscitation;signal processing;Signal Transduction;System;Techniques;Technology;Testing;Time;Translating;United States;Vasoconstrictor Agents;Ventricular Fibrillation;Vital Status

PROJECT_TITLE: Transforming Resuscitation through Artificial INtelligence (TRAIN Study)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE SUMMARY Identifying the effects of a significant stressor, the COVID-19 pandemic, and underlying systemic conditions, defined together as a syndemic, on mothers and children is critically important, as impaired parenting impacts neonatal development and infant/early child mental health. This study aims to apply complementary methods to investigate maternal experiences of the syndemic, note differences between Black and non-Latinx White (NLW) women’s experiences, identify other stressors that may impact women’s mental health, and talk with Black women about their experiences with the syndemic and racism. We will observe early child development and parental interactions at ages 24 and 48 months, to identify how toddlers’/preschoolers’ environment and mothers’ mental health contribute to their development and well-being.

PI_NAMEs: NJOROGE, WANJIKU FELICIA MBUGUA (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Achievement;Acute;Address;Adult;Adverse event;adverse outcome;Affect;Age;Anxiety;behavioral health;Black race;black women;care providers;Caregivers;Child;Child Behavior;Child Development;Child Health;Child Mental Health;Child Rearing;Clinical;Communities;COVID-19 pandemic;COVID-19 pandemic effects;culturally appropriate intervention;Data;Development;Developmental Process;Diagnostic;Disproportionately impacts women;Distress;Early identification;Education;emotion regulation;Enrollment;Ensure;Environment;Environmental Risk Factor;Epidemic;ethnic diversity;ethnic health disparity;experience;Exposure disparity;Family;Fathers;follow-up;Fostering;Fracture;Future;Goals;Health;health care disparity;health disparity;health equity;Healthcare;Healthcare Systems;Height;Housing;Impairment;improved;Indigenous;Inequity;Infant;Institute of Medicine (U.S.);Interview;Knowledge;Latinx;life span;Link;Longitudinal cohort;Maternal Health;Mental Depression;Mental Health;Methods;Mother-Child Relations;Mothers;Neonatal;neurodevelopment;novel;Nursery Schools;Outcome;pandemic disease;pandemic impact;pandemic stressor;Parent-Child Relations;Parents;Perception;Perinatal;Personal Satisfaction;physical conditioning;Postpartum Period;Postpartum Women;pregnant;Pregnant Women;prenatal;prevent;Prospective Studies;Psychopathology;psychosocial;Questionnaires;racial disparity;racial diversity;racism;recruit;Reporting;Research;resilience;resilience factor;Risk;Risk Factors;Sampling;SARS-CoV-2 exposure;screening;Secondary to;self reliance;Series;Severities;social;Social support;Stress;stressor;Structural Racism;Structure;Surveys;symptomatology;Symptoms;syndemic;System;therapy development;Time;time interval;Toddler;transmission process;Trust;United States;White Women;Woman

PROJECT_TITLE: Prenatal to Preschool: The Impact of the Pandemic on Mothers and children, with a focus on syndemic effects on Black families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Obesity;Contraception/Reproduction;Diabetes;Estrogen;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Polycystic Ovary Syndrome (PCOS);Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Polycystic ovary syndrome (PCOS), one of the most common endocrinopathies in women, presents with anovulation and hyperandrogenism in adolescence, and is associated with multiple co-morbidities. Research on the presentation and response to treatment in youth is limited, and no mechanism is currently available in the United States to query the early natural history and response to existing medications in a diverse population of youth with PCOS. The overall goal of the project is to describe the presenting reproductive and metabolic phenotypes, natural history, and response to therapy in a large sample of geographically, ethnically and racially diverse youth with PCOS, as a first step to develop personalized therapy strategies, and priority areas for development of new therapeutics.

PI_NAMEs: CREE, MELANIE G (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acanthosis Nigricans;Acne;Address;Adolescence;Adolescent;Adult;Adult women;Affect;Alanine Transaminase;Androgens;Androstenedione;Anovulation;Anxiety;Area;Australia;Biological;Blood Pressure;Body mass index;Body Weight;Body Weight decreased;Caring;Characteristics;Chronic;Clinical;Cluster Analysis;cohort;community center;comorbidity;Contraceptive Agents;Country;Data;Databases;Dermatologic;Development;Diabetes Mellitus;Diagnosis;diagnostic criteria;direct application;Disease;Eating Disorders;Estrogens;ethnic difference;ethnic diversity;Ethnic Origin;experience;Familial disease;Family;Fasting;fasting glucose;follow-up;Future;Genomics;Geography;girls;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;Health;Heterogeneity;High Density Lipoproteins;High Prevalence;Hirsutism;Hispanic;Hormones;Hour;Hyperandrogenism;Hypergravity;Hyperlipidemia;Hypertension;improved;indexing;Institution;Insulin;Insulin Resistance;insulin sensitivity;International;Laboratories;Life Style;Life Style Modification;Lifestyle Therapy;Luteinizing Hormone;Measures;Medical;Menstruation;Mental Depression;Mental disorders;Metabolic;Metabolic Diseases;metabolic phenotype;Metformin;Methods;Modeling;Multicenter Studies;Natural History;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Obstructive Sleep Apnea;OGTT;Overweight;Patients;Pattern;personalized approach;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Phenotype;Polycystic Ovary Syndrome;Population;Population Heterogeneity;predicting response;Pregnancy;Process;Prospective Studies;psychologic;Puberty;Race;racial difference;racial diversity;Recommendation;Recording of previous events;Registries;reproductive;Research;Research Personnel;response;Sampling;Sex Hormone-Binding Globulin;Site;Symptoms;Teenagers;Testosterone;therapeutically effective;Time;treatment response;United Kingdom;United States;waist circumference;Weight;Woman;women's treatment;Work;Youth

PROJECT_TITLE: The presentation and medical course of PCOS in adolescents across the United States

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative We will develop a new implantable medical device for treating severe psychiatric illness, especially mood and anxiety disorders. Many, if not all, of these disorders arise from communication failure in distributed brain networks, networks that communicate through rhythmic, oscillatory firing of large groups of brain cells. Our device will implement new algorithms that measure and control that rhythmic firing, restoring patterns of healthy communication.

PI_NAMEs: SHOARAN, MAHSA ;WIDGE, ALIK S. (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acceleration;Algorithms;analog;animal safety;Animal Testing;Anxiety Disorders;Area;Behavioral;Brain;brain cell;brain dysfunction;Brain region;Budgets;Clinic;Clinical;cognitive function;cognitive neuroscience;commercialization;Communication;Complex;conditioning;Consensus;Contracts;Coupling;Data;Data Analyses;Deep Brain Stimulation;design;Detection;Devices;digital;Disease;Ecosystem;Electric Stimulation;Electronics;Electrophysiology (science);emotional functioning;Epilepsy;Equipment;fabrication;Failure;first-in-human;Frequencies;Future;Human;Implant;improved;in vivo;Individual;industry partner;innovation;integrated circuit;Laboratory Animals;Machine Learning;Manufacturer;Marketing;Measurement;Measures;Medical;Medical Device;Medical Device Designs;medical implant;Mental disorders;Methods;microelectronics;Minnesota;Modeling;Modernization;Monitor;Mood Disorders;Movement Disorders;nanofabrication;neural;neural implant;Neurosciences;Neurosciences Research;neurotechnology;neurotransmission;novel strategies;novel therapeutics;Output;Parkinson Disease;Patients;Pattern;Performance;Periodicity;Phase;Physiologic pulse;Physiology;Play;Positioning Attribute;Protocols documentation;prototype;psychiatric symptom;Psychiatric therapeutic procedure;Psychiatry;Qualifying;Rattus;Resolution;Risk;Rodent;safety testing;Seizures;signal processing;Signal Transduction;Speed;Structure;success;Symptoms;System;Techniques;Technology;Testing;Therapeutic Effect;Time;tool;Translating;translational barrier;translational neuroscience;Tremor;trigonometry;Universities;Validation;Work

PROJECT_TITLE: Implantable Neurostimulators for Control of Oscillatory Brain Networks

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The central nervous system is an HIV reservoir and a barrier to cure of the virus. In this project, we will study the effect of a novel treatment with baricitinib to decrease the central nervous system HIV reservoir in people with HIV. If successful, this medication could be part of combination HIV cure treatments in the future.

PI_NAMEs: GAVEGNANO, CHRISTINA  (contact);MARCONI, VINCENT CHARLES;TYOR, WILLIAM R

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: AIDS clinical trial group;Antibodies;antiretroviral therapy;Authorization documentation;Behavioral;Biological Assay;Biological Availability;Blood;Brain;brain parenchyma;brain tissue;Cells;Central Nervous System;Cerebrospinal Fluid;Clinic;Clinical;COVID-19;CXCL10 gene;cytokine;Data;depressive symptoms;DNA;Dose;Drug Kinetics;efficacy evaluation;Emergency Situation;Encephalitis;FDA approved;Future;Genetic;Goals;HIV;HIV Antibodies;HIV Envelope Protein gp120;HIV Infections;IL7 gene;immune activation;Immunologic Markers;improved;In Vitro;in vivo;Individual;Infection;inflammatory marker;inhibitor;inhibitor therapy;innovation;Interleukin-15;Intervention;Janus kinase;life span;Light;Link;Macaca mulatta;Magnetic Resonance Imaging;member;Mental Depression;Microtubule-Associated Protein 2;Modeling;Morbidity - disease rate;mortality;mouse model;Myelofibrosis;Neopterin;Neurocognitive Deficit;neurofilament;Neurons;neuroprotection;Neuropsychology;novel;Opportunistic Infections;Oral;Participant;Performance;Peripheral;Persons;Pharmaceutical Preparations;Phase;phase 2 study;phase 3 study;phenotypic biomarker;Placebos;Polycythemia Vera;pre-clinical;preference;Property;Publishing;Randomized;randomized placebo controlled study;Regimen;Renal clearance function;Reporting;Research;Retroviridae Infections;Rheumatoid Arthritis;Risk;RNA;Safety;side effect;Site;social stigma;Source;Spectrum Analysis;symposium;Testing;Therapeutic;Virus;Virus Diseases;Work

PROJECT_TITLE: Phase II study to evaluate the efficacy and safety of baricitinib for reduction of HIV in the central nervous system

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Childhood ADHD is one of the most common neurodevelopmental disorders with prevalence of 5-10% across the globe, and is characterized by pervasive deficits in cognitive control and motivation. This project seeks to uncover dynamic cognitive processes and functional brain circuits underlying impaired cognitive control, its modulation by reward and their relation to core ADHD symptoms. The proposed research will provide new insights into the brain and cognitive bases of childhood ADHD using novel cognitive, neuroscience and computational models and will contribute foundational knowledge that eventually facilitate more effective and precise interventions to reduce the global burden of ADHD.

PI_NAMEs: CAI, WEIDONG  (contact)

PROJECT_TERMS: Address;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;base;Behavior;Behavioral;Biological;boys;Brain;brain dysfunction;Brain imaging;Child;Childhood;cingulate cortex;Classification;Clinical;Cognitive;cognitive control;Cognitive deficits;cognitive neuroscience;cognitive process;computational neuroscience;computer framework;Computer Models;Development;Diagnosis;Disease;expectation;Family;Financial Hardship;Functional disorder;Future;girls;Goals;Hyperactivity;Impaired cognition;Impairment;improved;Impulsivity;inattention;Individual;Individual Differences;innovation;insight;Intervention;Knowledge;Link;Mental disorders;Modeling;Motivation;Neurobiology;Neurodevelopmental Disorder;Neurosciences;novel;Nucleus Accumbens;Performance;Prefrontal Cortex;Prevalence;Process;psychologic;Research;response;Rewards;Schizophrenia;Severities;Sex Differences;social;Social Functioning;Societies;Speed;Subgroup;Symptoms;System;Testing;Time;United States National Institutes of Health

PROJECT_TITLE: An integrative framework of cognitive control and reward modulation in children with ADHD: from brain dynamics to clinical symptoms


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The goal of the proposed project is to develop a low-cost screening assay based on DNA methylation biomarkers to improve detection of early-stage ovarian cancer in high-risk women using liquid Pap specimens obtained during routine gynecological examination.

PI_NAMEs: PISANIC II, THOMAS RUSSELL;SHIH, IE-MING ;WANG, TIAN-LI ;WANG, TZA-HUEI JEFF  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;Achievement;Address;Algorithms;assay development;Benign;Bioinformatics;Biological Assay;Biological Markers;Biometry;BRCA mutations;Cancer Biology;cancer type;Carcinoma;Carcinoma in Situ;Case/Control Studies;Cervix Uteri;Clinical;Clinical assessments;Clinical Research;Clinical Sensitivity;cohort;Collaborations;Complex;cost;cost effective;Curative Surgery;Cytology;Detection;detection assay;Development;Diagnosis;diagnostic technologies;digital;Discrimination;Disease;DNA;DNA Methylation;early detection biomarkers;Early Diagnosis;Engineering;epigenetic marker;Epigenetic Process;Excision;Exhibits;Feces;Female Genital Diseases;Fluorescence;genome wide methylation;Germ-Line Mutation;Goals;Gynecologic;Gynecologic Pathology;high risk;High Risk Woman;Hypermethylation;imaging modality;improved;instrumentation;Intercept;Laboratories;Lesion;liquid biopsy;Liquid substance;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mammography;melting;Methods;Methylation;methylation biomarker;Microfluidic Microchips;Microfluidics;Morbidity - disease rate;mortality;multidisciplinary;multiplex assay;neoplastic cell;novel;Operative Surgical Procedures;Ovary;Pap smear;parallelization;Pathology;Patients;Performance;performance tests;ratiometric;Recording of previous events;Research;Research Personnel;Resolution;Sampling;Scheme;screening;Sensitivity and Specificity;Serous;Side;Specificity;Specimen;Statistical Models;success;Survival Rate;Symptoms;Techniques;Technology;Testing;Time;Tissues;Training;Translating;Travel;tumor;tumor progression;Tumor stage;Ultrasonography;user-friendly;Vagina;variant detection;Woman;Work

PROJECT_TITLE: Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Symptom relapse is quite common in the course of illness of schizophrenia, yet its pathophysiology has not been well captured in most previous research, as few studies account for the common confounder of treatment non-adherence. In this proposal, we aim to study brain functioning in individuals treated with long acting injectable antipsychotics at the time of relapse, for whom medication delivery can be confirmed. The results from this study will generate knowledge about the essential brain mechanisms of psychosis relapse despite confirmed medication delivery.

PI_NAMEs: RUBIO, JOSE M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adherence;Affect;Antipsychotic Agents;Automobile Driving;Belief;Biological Markers;Brain;Clinical;Corpus striatum structure;Data;design;Dopamine;experience;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Health Care Costs;Hospitalization;improved;indexing;Individual;Injectable;innovation;Inpatients;Knowledge;Literature;Magnetic Resonance Imaging;Measures;Mediating;medication compliance;neurobiological mechanism;neuromelanin;novel strategies;Occupational;Patients;Pharmaceutical Preparations;Play;Prognostic Marker;Psychoses;Psychotic Disorders;Quality of life;Recurrence;Relapse;relapse prevention;Research;response;Rest;reward processing;Rewards;Role;Schizophrenia;Social Functioning;Symptoms;Testing;Time;transmission process;treatment adherence;treatment response

PROJECT_TITLE: Striatal Function in Psychosis Relapse

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This program will train scholars and mentors on state-of-the-art methods for sampling, size estimation and engagement of hard-to-reach populations to improve social science and health disparities research.

PI_NAMEs: ARAYASIRIKUL, SEAN ;HOFFMANN, THOMAS ;MCFARLAND, WILLIAM ;MIRZAZADEH, ALI  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Archives;Area;Behavioral;behavioral and social science;California;career;Clinical Research;cohort;community based participatory research;Complex;Consultations;Data;Degree program;Disease;disparity elimination;Disparity population;Drug user;E-learning;Education;ethnic minority;Ethnography;experience;Faculty;faculty mentor;Female Adolescents;gang;gender minority;Goals;graduate student;Grant;H2 gene;hands on research;Health;Health Disparities Research;health disparity;Health Resources;Health Sciences;Health system;HIV;Homelessness;Housing;Immigrant;improved;Individual;innovation;Intervention;knowledge hub;lectures;Life;marginalized population;Measures;member;men who have sex with men;Mentors;Mentorship;Methodology;Methods;next generation;participant retention;Persons;Policies;Population;Population Heterogeneity;Population Sizes;Populations at Risk;programs;Public Health;racial minority;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resources;Sampling;Schedule;Schools;Services;severe mental illness;sex;Sexual and Gender Minorities;Short-Term Course;skills;social disparities;social science research;Social Sciences;Street Child;Surveys;Testing;Training;Training Programs;transgender;Universities;Vaccines;Youth

PROJECT_TITLE: Short Trainings on Methods for Recruiting, Sampling, and Counting Hard-to-Reach Populations: The H2R Training Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Quiescence is a critical property of adult muscle stem cells, but how it is maintained and how these cells transition into the activated state in response to muscle damage are poorly understood. We have developed in vitro techniques allowing the study of muscle stem cells in a more quiescent state than previously possible, and propose research that will illuminate both quiescence and transition into the activated state. Such information is required for muscle stem cells to be utilized in a therapeutic setting for muscle diseases or aging.

PI_NAMEs: KRAUSS, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adult;Axon;Basal lamina;Binding Proteins;Biological;Cadherins;Cell Communication;Cell Physiology;Cells;Cellular biology;Cellular Morphology;Cytoskeletal Proteins;Cytoskeleton;Engraftment;F-Actin;Fluorescent Probes;Genetic;Genetic study;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Image;In Vitro;in vivo;Injury;Knowledge;Maintenance;Methodology;Methods;Microscopy;Microtubules;Minus End of the Microtubule;Molecular;Molecular Analysis;Morphology;Motility;Mus;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Myoblasts;Myopathy;Natural regeneration;Nature;Neurons;novel;novel marker;Play;Preparation;Procedures;Process;Proliferating;Property;Protocols documentation;regeneration following injury;Regenerative capacity;Regenerative Medicine;Regulation;Research;response;Role;Scanning;Signal Transduction;Signaling Protein;Skeletal Muscle;stem cell biology;stem cells;Structure;Surface;System;Techniques;Testing;Therapeutic;Therapeutic Agents;Time;Tissues

PROJECT_TITLE: Cadherin-Dependent Regulation of Satellite Cell Function

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Mantle Cell Lymphoma is an aggressive and usually fatal subtype of Non-Hodgkin's Lymphoma whose pathogenesis is poorly understood, and new therapeutic options are urgently needed to improve the care of MCL patients. The transcription factor SOX11 is over-expressed in over 90% of MCL tumors and is associated with poor prognosis. Using a combinatorial approach that incorporates novel mouse models of MCL, small molecule SOX11 inhibitors, Ibrutinib(BTKi) and/or Venetoclax(BCL2i) resistant primary samples and PDX models, this application will define the role of SOX11 overexpression in MCL and explore the utility of inhibiting SOX11 directly as a novel therapeutic avenue for this incurable disease.

PI_NAMEs: PAREKH, SAMIR  (contact);WANG, MICHAEL

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Animal Model;B Cell Proliferation;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Blood;Bone Marrow;candidate validation;Caring;CD19 gene;CD72 gene;Cell Cycle;Cell Line;Characteristics;chemotherapy;ChIP-seq;Clinical Trials;combinatorial;Complement 3d Receptors;Cyclin D1;cytotoxicity;Data;Development;Diagnostic;Disease;DNA;DNA Binding;Drug resistance;efficacy evaluation;efficacy testing;Elements;Family;Foundations;Genes;Genetic Transcription;Human;human model;Immune;Immunophenotyping;improved;In Vitro;in vivo;in vivo Model;inhibitor;insight;Lesion;Lymphoma cell;Lymphomagenesis;Mantle Cell Lymphoma;Mediating;Modeling;Molecular Probes;mouse model;Mus;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel therapeutics;Other Genetics;Outcome;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;peripheral blood;Phenotype;Prognosis;Proliferating;protein kinase C beta;Publishing;Relapse;Research Personnel;Resistance;Resources;RNA Interference;Role;Sampling;Signal Transduction;small molecule;SOX11 gene;Spleen;standard of care;Structural Models;Testing;Therapeutic;transcription factor;transcriptome sequencing;Transgenic Animals;Transgenic Mice;Transgenic Organisms;tumor;tumor growth;Xenograft Model

PROJECT_TITLE: Targeting SOX11 in Mantle Cell Lymphoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research;Stroke

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (“gepants”) and anti-CGRP or anti- CGRP-receptor monoclonal antibodies (“nezumabs”) are novel treatments for migraine. The proposal will rigorously examine the cerebrovascular safety of CGRP antagonism. The results will help refine the therapeutic paradigm and the target population of migraine sufferers in whom CGRP antagonists can safely be used.

PI_NAMEs: AYATA, CENK  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;Age;aged;Aging;Animals;antagonist;arm;Blood Vessels;blood-brain barrier penetration;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Case Study;Cerebral Ischemia;cerebrovascular;Cerebrovascular Circulation;cerebrovascular imaging;Cerebrum;Chronic;Classic Migraine;clinical development;Clinical Trials;comorbidity;Conflict of Interest;Data;Defect;Diabetes Mellitus;diabetic;Distal;Dose;Drug Industry;Event;Exclusion;experimental study;Familial Hemiplegic Migraine;Female;Flowmetry;Functional disorder;Funding;Future;Goals;Hand;Homeostasis;Hypertension;hypertensive;Imaging Device;Impairment;in vivo;Industry;Infarction;Ischemia;Ischemic Stroke;Knock-in Mouse;Laboratories;Lasers;light scattering;Magnetic Resonance Imaging;male;Mediating;Methods;Middle Cerebral Artery Occlusion;Migraine;migraine treatment;Mission;Modeling;Monoclonal Antibodies;mortality;Mus;Myocardial Infarction;Neurologic Deficit;novel;Optical Coherence Tomography;optical imaging;optogenetics;Outcome;patient population;Patients;Penetration;Perfusion;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;Prophylactic treatment;Rattus;Reporting;Reproducibility;Research;response;Risk;Risk Factors;risk mitigation;Safety;small molecule;spreading depression;Stroke;Structure;Target Populations;Testing;Therapeutic;Transient Ischemic Attack;Trust;two photon microscopy;United States National Institutes of Health;vascular risk factor;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Safety of Anti-CGRP Migraine Therapeutics in Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE To understand the molecular and cellular mechanisms how protective immune responses are elicited by invading pathogens or vaccines would be useful for the design of vaccines. This project aims to study mechanisms of B cell responses to particulate antigens, or mock viral particles, at molecular and cellular level. The successful completion of this project will fill in a gap in our knowledge regarding how B cells may be activated by viral pathogens.

PI_NAMEs: CHENG, WEI  (contact);ZIKHERMAN, JULIE

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Affinity;Animals;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Autoantigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biophysics;Cell Communication;Cells;Chemicals;Dedications;density;Dissection;DNA;Encapsulated;Ensure;Epitopes;Event;expectation;Exposure to;functional outcomes;Generations;Genetic;Genetic Materials;Germ Lines;Goals;Human;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;innovation;Invaded;Investigation;Knowledge;Liposomes;live cell imaging;Mediating;Membrane Proteins;Memory B-Lymphocyte;MHC Class II Genes;Modeling;Molecular;Mus;novel;novel vaccines;Nucleic Acids;particle;Particle Size;Particulate;pathogen;pathogenic virus;Plasma Cells;programs;Proliferating;Proteins;rational design;Receptor Signaling;Recovery;Reporter;response;RNA;Shapes;Signal Pathway;Signal Transduction;single molecule;success;Surface;Surface Antigens;synergism;System;T-Lymphocyte;Techniques;Testing;Time;Titrations;Toll-like receptors;Transgenic Model;Vaccine Design;Vaccines;Viral;Viral Antigens;Viral Genome;viral pandemic;Viral Vaccines;Virion;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of B cell responses to particulate antigens

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Diabetic Retinopathy (DR) is a leading cause of vision loss in the US. Individuals with diabetes are instructed to receive annual eye exams until visible vascular changes appear which take 10-15 years to develop. The established premise that DR is only a microvascular disease, as clinically defined, has been challenged in recent years by evidence that retinal neurons undergo changes in function and structure prior to the vascular pathology. A fundamental gap in our knowledge of DR pathology is whether neuronal dysfunction is associated with or causal to the late stage vascular defects. The proposed experiments in Veterans with diabetes are designed to elucidate if neuronal defects precede vascular defects in DR and if treating neuronal deficits with levodopa early in DR will prevent the late-stage vascular defects that result in vision loss. The proposed work will inform the clinical management of DR and potentially shift detection and treatment earlier to prevent vision loss.

PI_NAMEs: PARDUE, MACHELLE T. (contact)

PROJECT_TERMS: Affect;Aneurysm;Angiography;Animal Model;Appearance;Blindness;Blood Glucose;Blood Vessels;Carbidopa;Clinical;Clinical Management;clinical practice;Clinical Research;cohort;Data;Defect;design;Detection;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;diagnostic biomarker;Disease;Dopamine;early screening;Early treatment;Electroretinography;experimental study;Eye;follow-up;Functional disorder;Fundus;Fundus photography;glycemic control;Glycosylated hemoglobin A;Hemorrhage;illness length;Individual;Knowledge;Lesion;Levodopa;Link;Measurement;Measures;Microaneurysm;Microvascular Dysfunction;Monitor;National Eye Institute;Neural Pathways;Neural Retina;Neurologist;Neuromodulator;Neuronal Dysfunction;Neurons;neuroprotection;ophthalmic examination;Optical Coherence Tomography;Outcome Measure;Participant;Pathology;Pathway interactions;Patients;Persons;Placebos;preservation;prevent;primary outcome;randomized, clinical trials;Recovery;Renal function;response;Retina;Retinal Diseases;retinal neuron;Risk;Rod;Rodent Model;side effect;Sinemet;standard of care;Structure;success;Testing;Therapeutic;treatment duration;United States National Institutes of Health;Veterans;Vision;Visual;Work

PROJECT_TITLE: Treating early stage diabetic retinopathy

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more severe than outpatient settings. Obstructive sleep apnea (OSA) is highly comorbid with both disorders and untreated OSA is associated with worse functional impairment across multiple domains, worse quality of life, worse PTSD, higher suicidal ideation, and higher substance use and relapse rates. Treating OSA with evidence-based positive airway pressure (PAP) in Veterans with SUD/PTSD on a residential unit is a logical way to maximize treatment adherence and treatment outcomes. This study compares OSA treatment while on a SUD/PTSD residential unit to a waitlist control group. We hypothesize that treating OSA on the residential unit, compared to the waitlist control, will have better functional, SUD, and PTSD outcomes.

PI_NAMEs: COLVONEN, PETER  (contact)

PROJECT_TERMS: Adherence;adherence rate;Affect;Aftercare;Alcohol consumption;Arousal;Back;Blood;Breathing;Caring;Clinical;clinical practice;comorbidity;Control Groups;coping;desensitization;Diagnosis;Disease;distraction;drinking;Early Intervention;Effectiveness;Emotional;evidence base;Exhibits;Feeling suicidal;Female;follow up assessment;follow-up;functional disability;Functional impairment;functional improvement;functional outcomes;Goals;group intervention;Health;Health Care Costs;Heart failure;Hour;Hypertension;Impairment;improved;Individual;Knowledge;Link;male;Mental Depression;Mental Health;methamphetamine use;Methodology;military veteran;Obesity;Obstructive Sleep Apnea;opioid use;Outcome;Outpatients;Participant;Patients;Peripheral;Physical Function;positive airway pressure;Post-Traumatic Stress Disorders;Protocols documentation;psychologic;Quality of life;randomized, controlled study;Recovery;reduced substance use;Relapse;Research;Residential Treatment;response;screening;Severities;Sleep disturbances;Sleep Fragmentations;social;standard care;stressor;substance use;Substance Use Disorder;substance use treatment;suicidal behavior;Suicide;Suicide attempt;sustained recovery;Symptoms;Time;timeline;treatment adherence;Treatment Efficacy;treatment group;Treatment outcome;treatment program;Veterans;Wait Time;Waiting Lists;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Examining Early Intervention Obstructive Sleep Apnea Treatment on Long-Term Outcomes in Veterans with SUD/PTSD in a Residential Treatment Program

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Congenital Structural Anomalies;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Children with Down syndrome are at increased risk for acute leukemia treatment-related toxicities, but few studies have investigated survivorship outcomes in this subgroup. The proposed work will compare chronic health conditions, neuropsychological outcomes, and quality of life in Down syndrome survivors of acute leukemia to age and sex-matched children with Down syndrome and no history of cancer. Our objective is to comprehensively characterize outcomes in survivors of Down syndrome-associated acute leukemia and identify related risk factors, in order to inform clinical practice guidelines for survivorship care of this understudied and vulnerable population.

PI_NAMEs: GRAMATGES, MARIA MONICA (contact);JACOLA, LISA M;LUPO, PHILIP ;RABIN, KAREN R

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Acute;Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;adverse outcome;Age;Age of Onset;Area;Attention;Biological;Biology;cancer diagnosis;cancer epidemiology;cancer health disparity;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Case Series;Cataract;Cerebrovascular Disorders;Child;Child Support;childhood cancer survivor;Chromosome 21;Chronic;Clinical;Clinical assessments;Clinical Practice Guideline;cohort;Cohort Studies;Collaborations;Congenital Abnormality;Congenital Heart Defects;Constitution;Coronary Arteriosclerosis;Data;Dementia;Developmental Disabilities;Disabling;Disparity;Down's Syndrome;Epilepsy;Ethnic Origin;Etiology;Exclusion;executive function;experience;Frequencies;Functional impairment;General Population;Genetic;genetic association;Genetic Diseases;Guidelines;Hair;Health;health disparity;health related quality of life;Health Status;Hearing problem;high risk population;improved;Incidence;Individual;Knowledge;Late Effects;Length;leukemia;leukemia treatment;Life;Longterm Follow-up;Malignant Neoplasms;Medical Records;Methods;multidisciplinary;Neurocognitive;Neuropsychology;Osteopenia;Outcome;outcome disparities;Parents;Participant;Pediatric Oncology Group;peer;Persons;Phenotype;polygenic risk score;Population;Populations at Risk;Premature Menopause;Prevalence;processing speed;prospective;Proxy;Quality of life;quality of life for cancer survivors;Race;Recording of previous events;recruit;Refractive Errors;Registries;Reporting;Research;research study;Risk;Risk Factors;Severities;sex;Site;Skin Wrinkling;sociodemographic factors;Socioeconomic Factors;Structural Congenital Anomalies;Subgroup;Surveys;Survivors;survivorship;Susceptibility Gene;telomere;Testing;Thyroid Diseases;Treatment outcome;Treatment-related toxicity;Trisomy;Visual;Vulnerable Populations;Work

PROJECT_TITLE: Chronic Health Conditions in Survivors of Down Syndrome-Associated Leukemia


NIH_SPENDING_CATS: Infectious Diseases;Pediatric

PHR: NARRATIVE We propose to provide research training in Pediatric Infectious Diseases. Graduates of our training program will have a significant impact on the Pediatric Infectious Diseases-related research needs and workforce of the nation.

PI_NAMEs: JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Research Training in Pediatric Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The Ph.D. program in Cellular and Molecular Medicine seeks to meet the immediate and ongoing need in the biomedical workforce to rigorously train a cadre of scientists to work at the interface between basic bench science and clinical medicine.

PI_NAMEs: RAO, RAJINI  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Molecular Medicine;Training Programs

PROJECT_TITLE: Training Program In Cellular and Molecular Medicine

STUDY_SECTION: TWD


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Kidney Disease;Lymphatic Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE High sodium environment can activate immune cells and stimulate lymphatic vessel growth. Our data reveal that kidney injury leads to renal accumulation of sodium, immune cells, and increased lymphatic vessel number but also causes a heretofore unrecognized impairment in lymphatic function connected to sodium transporters and lipid oxidation products. We propose intrarenal sodium directly stimulates lymphatic vessel growth but that lymphatic interaction with sodium-activated immune cells promotes interstitial stagnation subsequent tubulointerstitial fibrosis involving the sodium transporters and lipid oxidation products which we propose are novel targets to intervene in progressive kidney damage.

PI_NAMEs: KIRABO, ANNET ;KON, VALENTINA  (contact);SHELTON, ELAINE

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;adaptive immune response;adduct;Adoptive Transfer;Affect;Animals;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apolipoprotein A-I;Biological;blood pressure elevation;Blood Vessels;Calcium;Cell Communication;Cell Physiology;Cells;chemokine;Cholesterol;Chronic Kidney Failure;comorbidity;conditional knockout;constriction;Coronary heart disease;Cultured Cells;cytokine;Data;Disease;Elements;Endothelial Cells;Endothelin;Endothelin-1;Endothelin-3;Environment;epithelial Na+ channel;Fibrosis;Fluid Balance;Growth;Human;humanized mouse;hypertensive;Immune;immune activation;immune cell infiltrate;immune clearance;immunoregulation;Impairment;In Vitro;in vivo;Inflammation;Inflammation Mediators;Injury;Injury to Kidney;Intercellular Fluid;interstitial;Kidney;Kidney Diseases;kidney fibrosis;Ligands;Link;Lipids;Lymph;Lymphangiogenesis;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic pump;Lymphatic System;lymphatic vessel;Lymphocyte;macromolecule;Mannitol;Mediating;monocyte;mouse model;Mus;mutant;NADP;neoantigens;nephrotoxicity;novel;Oxidases;oxidation;Oxidative Stress;Pathway interactions;Population;promoter;Proteins;Publishing;receptor;recruit;renal damage;Renal function;response;Role;Skin;Sodium;Sodium Chloride;Sodium-Potassium-Chloride Symporters;Structure;T-Cell Activation;Testing;Time;Tissues;trafficking;Treatment Efficacy;uptake;urinary;Vascular Diseases;vasoconstriction;Water

PROJECT_TITLE: Salt Mediated Cross Talk Between Lymphatic Vessels and Immune Cells in Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

PHR: Narrative There are ~400,000 epilepsy patients in the U.S. who do not respond to medication and do not have visible lesions on their clinical brain imaging data. Without visible lesions on their brain images it is difficult to figure out where in the brain the seizure signals originate and provide neurosurgical treatment to stop their seizures. We propose to develop a type of brain imaging that will detect many of the epilepsy brain lesions that cannot currently be seen and thereby enable more epilepsy patients to have the option of neurosurgery.

PI_NAMEs: MCNAB, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Agreement;Alzheimer's Disease;Amygdaloid structure;Anisotropy;Architecture;Autopsy;Brain;Brain imaging;brain magnetic resonance imaging;brain tissue;Cerebral cortex;Clinic;Clinical;Contralateral;Cortical Dysplasia;Cortical Malformation;Custom;Data;density;Detection;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Electrocorticogram;Electrodes;Electroencephalography;Engineering;Epilepsy;epileptiform;Excision;Fiber;Gene Expression;gray matter;healthy volunteer;high risk;Hippocampus;Histologic;Histology;Homologous Gene;Human;Implant;implantation;improved;in vivo;innovation;Intractable Epilepsy;Lesion;Link;Location;Magnetic Resonance Imaging;Maps;Medical;Methods;Microscopy;Morphology;Multiple Sclerosis;neurofilament;neuroimaging;Neurology;neuropathology;neurosurgery;Operative Surgical Procedures;Outcome;Pathology;Patients;Pharmaceutical Preparations;Physics;Positioning Attribute;Probability;Reproducibility;Research;Resected;Sampling;Scalp structure;Schedule;Seizures;Signal Transduction;Technology;Testing;Time;Tissues;tractography;transcriptomics;Translating;white matter;Work

PROJECT_TITLE: Integration of Advanced Diffusion MRI and 3D Histology for Improved Neurosurgical Targeting

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Public Health Significance: Results from this project will facilitate an improved understanding of the genetic and neurobiological factors involved in opioid-related behaviors. Such knowledge should lead to the development of improved strategies for prevention and treatment of individuals who suffer from opioid use disorders.

PI_NAMEs: BACHTELL, RYAN K;EHRINGER, MARISSA A (contact);SABA, LAURA MAREN

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Absence of pain sensation;addiction;Address;Alcohol consumption;Amygdaloid structure;Analgesics;Animals;Bayesian Analysis;Behavior;Behavioral;behavioral phenotyping;Brain;brain tissue;Data;Data Set;Development;differential expression;Future;gene environment interaction;Gene Expression;gene network;Genes;Genetic;genetic approach;Genetic Models;Genetic Transcription;Genotype;Heritability;Human;Hybrids;Hyperalgesia;improved;Inbred Strains Rats;Individual;Intake;Knowledge;Maps;Measures;Mechanics;Mediator;Modeling;Motivation;neurobiological mechanism;Neurobiology;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid use disorder;Outcome;Oxycodone;oxycodone self-administration;Pain Measurement;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenotype;phenotypic data;Population;Predisposition;Prevention strategy;Protocols documentation;Public Health;Quantitative Trait Loci;rat genome;Rattus;Recombinant Inbred Strain;response;Risk;risk variant;Rodent Model;Role;Self Administration;System;Techniques;Testing;Time;Tissues;trait;transcriptome sequencing;United States;Withdrawal;Work

PROJECT_TITLE: Identification of genes and genetic networks contributing to opioid use disorder traits in the Hybrid Rat Diversity Panel


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: The Center for Studies in Demography and Ecology (CSDE) at the University of Washington proposes a training program to create a new generation of population scientists and demographers equipped with skills to conduct data intensive research with advanced computational and statistical methods. At the core of this program is a collaboration between CSDE, the eScience Institute (UW’s data science center), and the Center for Statistics and the Social Sciences (CSSS), three units with long standing relationships, a proven track record (including a BD2K track in Big Data for Demographic Research), and combined expertise in demographic methods, data science, computer science and statistical methods. Through this collaboration, trainees will take a series of coursework in the following areas: advanced statistical methods and machine learning, coding, databases, data visualization/communication, and data ethics.

PI_NAMEs: ALMQUIST, ZACK W;CURRAN, SARA R. (contact);MCCORMICK, TYLER ;WAKEFIELD, JONATHAN C

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TITLE: Data Science Training in Demography and Population Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There is a large gap in current biomedical research field to address development and training of individuals from underrepresented minorities who would serve as the next generation pool of qualified scientists studying host and microbe interaction. The MUSC RAISE program seeks to overcome barriers that have prevented or hindered undergraduate students from gaining experiences that would engage and inspire students to continue their professional careers in the field of Microbiology and Immunology. The major goal of the RAISE program is to foster the expansion of a cadre of diverse scientists who will become part of the biomedical workforce dedicated to the development of scientific advances to tackle human diseases and disease processes dynamically associated with host and microbe interplay.

PI_NAMEs: WESTWATER, CAROLINE ;YILMAZ, OZLEM  (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academic skills;Address;Admission activity;Advisory Committees;Area;Award;Awareness;Basic Science;Biomedical Research;Brothers;Cancer Center;Cancer Education Grant Program;Cardiovascular Diseases;Cardiovascular Physiology;career;Career Mobility;career networking;Climacteric;Clinical;college;Communicable Diseases;Communication;Communities;craniofacial;Creativeness;Data;Data Pooling;Dedications;Degree Completion;Degree program;Development;disadvantaged background;Disease;Doctor of Philosophy;economic disparity;Education;Educational Curriculum;Enrollment;Ensure;Environment;Equity;Ethnic Origin;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Fostering;Gender;Goals;graduate student;Growth;Health;health disparity;higher education;Historically Black Colleges and Universities;host-microbe interactions;human disease;Immune System Diseases;Immunology;improved;Individual;Institution;Interview;Investigation;Journals;Knowledge;Laboratories;Leadership;lectures;Life;Life Experience;Medical;member;Mentors;Microbe;Microbiology;minority student;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Drug Abuse;next generation;Oral health;Outcome;Participant;Patient Self-Report;peer;prevent;Process;Productivity;programs;public health relevance;Qualifying;Race;racial population;Records;recruit;Reproducibility;Request for Applications;Research;Research Project Grants;Research Training;Resources;responsible research conduct;Role;Schools;Science;Scientific Advances and Accomplishments;Scientist;Series;Sex Orientation;Sister;skill acquisition;skills;social disparities;Social support;Socioeconomic Status;South Carolina;Strategic Planning;Structure;student participation;Students;Substance Use Disorder;success;summer program;summer research;support network;Surveys;symposium;System;Talents;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Raise Awareness In Students Early (RAISE) Host and Microbe Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Discovering the genes and mechanisms that make one individual more vulnerable to addiction than another is key for designing better therapeutic interventions. Here we propose to create dozens of new mouse models for addiction that we will characterize for addiction behaviors, brain structure, and gene expression profiles in key brain regions known to regulate addiction. Successful completion of this project will yield rich datasets and mouse resources that can be exploited by the entire addiction research community to discover novel therapeutics for addiction.

PI_NAMEs: KUMAR, VIVEK  (contact)

PROJECT_TERMS: Acute;addiction;Animals;Anxiety;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;Biological;Biological Assay;Biology;Body System;Brain;Brain imaging;Brain region;brain reward regions;Candidate Disease Gene;Child;Cocaine;cocaine sensitization;Code;Collaborations;Communities;Complement;Corpus striatum structure;cost;Darkness;Data;Data Set;design;deviant;Drug abuse;drug response prediction;Economics;effective therapy;Emotional;experimental study;Gene Deletion;gene discovery;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Models;genetic resource;Genetic Transcription;genetic variant;genome wide association study;Genomics;Goals;Hippocampus;Hospitals;Human;Hyperactivity;Image;image processing;Impulsivity;in vivo;Individual;innovation;insight;Institution;knock out mouse project;Knock-out;knockout gene;Knockout Mice;Laboratories;Light;Link;loss of function;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medial;Mediating;mesolimbic system;Metabolism;Midbrain structure;Modeling;mouse genome;mouse model;Mus;mutant;mutant mouse model;Neuroanatomy;Neurobiology;neuron development;Neurons;novel;novel therapeutics;Outcome;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiology;pleiotropism;preference;Prefrontal Cortex;prepulse inhibition;Process;programs;Proteins;psychostimulant;Public Health;Publishing;Quantitative Trait Loci;Research;Resources;reverse genetics;Rewards;Rodent;scale up;Seizures;Self Administration;Sleep;social;Structure;System;Systems Analysis;Tail Suspension;Testing;The Jackson Laboratory;Therapeutic community technique;therapeutic development;Therapeutic Intervention;Tissues;trait impulsivity;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;virtual;Work

PROJECT_TITLE: Establishment and Characterization of Novel Mutant Mouse Models for the Addiction Research Community


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Alcohol use disorder is often comorbid with anxiety, depression, and stress, thereby, making it harder to maintain sobriety. To alleviate negative affective disturbances in abstinence, this project will provide insight on novel peptide targets within neural pathways that will lead to better diagnostic tools and treatment options.

PI_NAMEs: JARAMILLO, ANEL ARIANA (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;addiction;Affect;affective disturbance;alcohol abstinence;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Animal Model;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;Award;Behavior;Behavioral;Biological Availability;Brain Stem;Calcitonin Gene-Related Peptide;career;career development;Cell Nucleus;cell type;Cells;Chronic;chronic alcohol ingestion;Clinical Trials;Communication;comorbidity;Complex;Corticotropin-Releasing Hormone;Data;Development;diagnostic tool;Electrophysiology (science);Ethanol;experience;Female;Fiber;Fright;Goals;hypothalamic-pituitary-adrenal axis;in vivo;Individual;insight;interest;Learning;Maintenance;Measures;Mental Depression;Mentors;Mus;negative affect;neural circuit;Neural Pathways;Neurons;Neuropeptides;neurophysiology;neuroregulation;novel;Pain;parabrachial nucleus;Pathway interactions;peptide hormone;Peptides;Peripheral Nervous System;Pharmacological Treatment;Pharmacology;Pharmacotherapy;Phase;Photometry;pituitary adenylate cyclase activating polypeptide;polypeptide;Population;Pre-Clinical Model;preclinical study;Regulation;Relapse;Reporter;Research;Resolution;response;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;skills;sobriety;Specificity;Stress;Structure of terminal stria nuclei of preoptic region;Synapses;System;Testing;therapeutic target;Training;Transgenic Animals;Transgenic Organisms;vapor

PROJECT_TITLE: Neuropeptide-dependent parabrachial control of the BNST during alcohol abstinence-induced negative affect

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Maintaining body heat is necessary to survive in the cold, but our understanding of thermoregulatory brain circuits remains incomplete. The proposed project will determine the specific brainstem neurons and circuit mechanisms that transform cold-sensory input into “cold-defense” behavioral and autonomic responses. This preclinical information holds the key to translational studies that will exploit thermoregulatory circuits for therapeutic benefit.

PI_NAMEs: GEERLING, JOEL CHARLES (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Accidents;Aging;Animals;Arousal;Axon;Behavior;Behavioral;Behavioral Assay;Behavioral Mechanisms;behavioral response;Bilateral;Body Surface;Body Temperature;Brain;Brain Injuries;Brain Stem;Cause of Death;Chronic;circadian;Classification;Climate;cold temperature;comorbidity;Critical Care;Critical Illness;defense response;Disease;Electroencephalography;Engineering;experimental study;Exposure to;falls;Food;FOXP2 gene;Genetic;Glutamates;Goals;Heart Arrest;Hypothalamic structure;Impairment;improved;Investigation;Knowledge;Lateral;Life;Location;Mammals;Measures;Medicine;metabolic rate;Methods;Molecular;motivated behavior;Motivation;Motor Activity;Mus;natural hypothermia;Nervous System Trauma;neural circuit;Neurologic;neuronal circuitry;Neurons;neuroprotection;obesity treatment;older adult;Ontology;Organ Transplantation;Outcome;parabrachial nucleus;pathological aging;Patients;Peripheral;Pharmaceutical Preparations;Phase;Population Heterogeneity;practical application;pre-clinical;preference;prevent;Prosencephalon;Protocols documentation;Public Health;response;Rewards;Sensory;sensory input;Site;Skin;Sleep;Sleep Deprivation;Space Flight;Spinal;Spinal Cord;Stimulant;Temperature;Testing;Therapeutic;Thermogenesis;Translating;Translational Research;translational study;Wakefulness;Work

PROJECT_TITLE: Brainstem cold-defense circuitry

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Gonorrhea affects about 87 million people globally, annually. The causative organism, Neisseria gonorrhoeae has become resistant to almost every antibiotic in clinical use. There is an urgent need o develop novel treatments against this disease. Here, we aim to develop camelid antibodies (nanobodies; also called VHHs) directed against N. gonorrhoeae that can serve as adjunctive treatment or as a preventive.

PI_NAMEs: RAM, SANJAY  (contact);SHOEMAKER, CHARLES BIX

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Affect;Affinity;Alpaca;anti-toxin;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Therapy;Antigens;Antimicrobial Cationic Peptides;Attenuated;B-Lymphocytes;Bacteria;bactericide;Binding;Binding Proteins;Biotechnology;Ceftriaxone;Cell division;Cells;Characteristics;Chlamydia;chronic pelvic pain;Clinical;Collaborations;Complement;Complement Factor H;Complement Membrane Attack Complex;Cytidine Monophosphate N-Acetylneuraminic Acid;Development;Disease;Drug Delivery Systems;drug-resistant gonorrhea;Drug-resistant Neisseria Gonorrhoeae;Ectopic Pregnancy;efficacy testing;Enzymes;Epitopes;Flow Cytometry;Genes;Goals;Gonorrhea;HIV;Human;hyperimmunization;IgG1;Immune;immune clearance;Immune Evasion;Immunization;Immunize;Immunoglobulin G;Immunotherapeutic agent;improved;in silico;In Vitro;in vivo;Incidence;Individual;Infection;infection burden;Infertility;Inflammatory Response;inhibitor;Lead;Libraries;Link;lipooligosaccharide;Mediating;Messenger RNA;Microbe;Modeling;Molecular Conformation;mucosal site;Multi-Drug Resistance;Mus;mutant;Mutation;nanobodies;Neisseria gonorrhoeae;novel;Organism;Pathogenesis;Pathway interactions;Persons;Phage Display;Predisposition;prevent;Prevention;Preventive;Property;Proteins;public health priorities;Reaction;receptor;Recombinants;Recommendation;Reporting;Resistance;screening;Sexually Transmitted Diseases;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Specificity;Surface;synergism;Technology;technology platform;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;Topical application;transmission process;trend;United States;vaccine candidate;Vagina;Vaginal Ring;Variant;Woman;Work

PROJECT_TITLE: Development of nanobody immunotherapeutics that prevent and treat gonorrhea

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ORG_DEPT: SURGERY

ORG_STATE: TX

PHR: NARRATIVE Non-small cell lung cancer (NSCLC) is a devasting disease and the leading cause of cancer-related death in the United States, for which surgery is a critical treatment option. During surgical procedures for patients with NSCLC, many important decisions are made by the surgeons to define the diagnosis of the tumor and the extent of tissue resection, however the clinical technologies that currently exist to support surgeons in these difficult assessments are outdated, slow, and prone to many errors, leading to dire consequences for patients. In our study, we propose to refine and validate a groundbreaking new technology that allows tissues to be accurately identified in the patient and on excised specimens, providing surgeons with new capabilities in obtaining real- time and molecular-based information to guide their surgical decisions and improve outcome for patients.

PI_NAMEs: BURT, BRYAN MICHAEL;SCHIAVINATO EBERLIN, LIVIA  (contact);WISEMAN, JUSTIN

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: accurate diagnosis;Adenocarcinoma;Biopsy;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer subtypes;cancer surgery;Caring;Cessation of life;Clinical;clinical care;clinical decision-making;Clinical Research;college;Data;Decision Making;Detection;Development;Devices;Diagnosis;Diagnostic;Disease;Evaluation;Excision;Freezing;Frequencies;Frozen Sections;Hand;handheld equipment;Hematoxylin and Eosin Staining Method;Histologic;Histopathology;improved;improved outcome;in vivo;in vivo evaluation;innovation;innovative technologies;Lobectomy;Lung;lung cancer screening;Lung nodule;Lymph Node Dissections;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Medicine;Metals;minimally invasive;Molecular;Molecular Diagnosis;Morphology;new technology;next generation;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;Observational Study;Operating Rooms;operation;Operative Surgical Procedures;Pathologist;Patient Care;Patient-Focused Outcomes;Patients;Performance;Procedures;Process;prospective;prototype;rapid diagnosis;Reporting;Reproducibility;research and development;Retrospective Studies;Robotics;Scientist;seal;Segmental Mastectomy;Side;Slide;specific biomarkers;Specificity;Specimen;Squamous Cell;Stains;standard of care;Sterility;Structure of parenchyma of lung;Surgeon;Surgical complication;Surgical margins;surgical risk;System;Techniques;Technology;technology validation;Testing;Thoracic Surgeon;Time;Tissue Banks;Tissue Sample;Tissues;Translating;Translations;tumor;tumor diagnosis;United States;Validation;Water

PROJECT_TITLE: Validation and Translation of MasSpec Pen Technology for Intraoperative Evaluation of Non-small Cell Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(57)R]


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The proposed research is relevant to public health because it focuses on identifying new therapeutic targets for neurological disorders, such as epilepsy, autism spectrum, or other pervasive developmental disorders. Determining how small G protein networks coordinate nervous system development and function will provide significant advances in the understanding of brain function and nervous system disorders at a fundamental level. Therefore, the proposed research is relevant to NIH’s mission to seek fundamental knowledge about living systems and to reduce illness and disability.

PI_NAMEs: CHERRA, SALVATORE JAMES (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Actins;Affect;Alzheimer's Disease;Animals;autism spectrum disorder;Binding;Biochemistry;Biological Assay;Biological Models;Biophysics;Biosensor;Brain;Caenorhabditis elegans;Cellular biology;cholinergic;cholinergic neuron;cholinergic synapse;Complex;Data;Development;disability;Dominant-Negative Mutation;Electron Microscopy;Electrons;Ensure;Epilepsy;F-Actin;Fluorescence Microscopy;Foundations;Functional disorder;Future;Genetic;Genetic Engineering;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Impairment;improved;In Vitro;in vitro Assay;in vivo;innovation;insight;Intellectual functioning disability;Knowledge;Light;light microscopy;Maintenance;Measures;Microfilaments;Microscopic;Mission;Modeling;Molecular;Molecular Target;Monomeric GTP-Binding Proteins;Motor;motor neuron development;Motor Neurons;mutant;Mutation;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuromuscular;Neuromuscular Junction;neuronal circuitry;Neurons;Neurophysiology - biologic function;Neurosciences;new therapeutic target;novel therapeutics;Organism;Pathway interactions;Pervasive Development Disorder;polymerization;Polymers;presynaptic;Presynaptic Terminals;prevent;Process;protein degradation;protein protein interaction;Proteins;Public Health;ras GTPase-Activating Proteins;Regulation;Research;restoration;Schizophrenia;Series;Signal Pathway;Signal Transduction;Signaling Protein;Synapses;synaptic function;Synaptic Vesicles;therapeutic development;tool;United States National Institutes of Health

PROJECT_TITLE: Regulation of synapse development by small GTPase cascades in Caenorhabditis elegans

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]