ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Uterine Cancer;Women's Health Research

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative We anticipate our work will offer in depth information about molecular mechanisms governing endometrial epithelium homeostasis. Our work will dramatically improve our understanding of endometrial carcinoma pathogenesis and lay the essential foundation for translational studies, such as identification of unique biomarkers and therapeutic targets based on stratification of endometrial carcinoma according to their cell of origin and causative genetic alterations. Our studies will also provide a solid basis for future studies of other critical issues of reproductive biology, such as infertility and endometriosis.

PI_NAMEs: NIKITIN, ALEXANDER Y. (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Adjuvant Therapy;Adult;Behavior;Biological;Biological Markers;Body of uterus;Bone Marrow Cells;Cancer Etiology;cancer type;Carcinoma;Cell Differentiation process;Cell Lineage;cell type;Cells;Cessation of life;Characteristics;Clinical;clinically relevant;Colorectal Cancer;Death Rate;differential expression;Endometrial;Endometrial Carcinoma;endometrial organoid;Endometrioid Carcinoma;endometriosis;Endometrium;Ensure;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Estrogen Replacement Therapy;Estrous Cycle;experimental study;Foundations;Future;Gene Modified;Genomics;Gland;Homeostasis;Human;Human Biology;improved;Incidence;Individual;Indolent;Infertility;insight;Link;Location;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mesenchymal;Molecular;Molecular Abnormality;molecular subtypes;mouse model;Mus;Mutation;Natural regeneration;Neoplasms;old mice;older women;Organ;Organoids;Pathogenesis;Pathologic;Phase;Phenotype;Physiological;Population;Predisposition;Proliferating;Recurrence;Reporter;Reproductive Biology;Reproductive History;Role;Serous;single-cell RNA sequencing;Solid;stem cell self renewal;stem cells;stemness;Stratification;stromal progenitor;Supporting Cell;System;Testing;therapeutic target;therapeutically effective;Time;tissue stem cells;Tissues;TP53 gene;transcriptome;translational study;tumor;Uterine Cancer;Uterus;Vascularization;Women's mortality;Work;Xenograft procedure

PROJECT_TITLE: Endometrial epithelial stem cells and cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The past decade in neuroscience has focused on unveiling and characterizing the diversity of neuronal populations, but the developmental mechanisms by which this diversity is generated is relatively unknown. By studying the role of Satb1 levels in the generation of the diverse features of cortical somatostatin interneuron subtypes, this proposal seeks to uncover basic developmental mechanisms that are used to generate neuronal diversity.

PI_NAMEs: LEE, JINOH  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Adult;Alleles;Antibodies;Award;Binding;Biological Assay;Brain;Categories;Cell Nucleus;cell type;Cells;Cerebral cortex;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Complex;conditional knockout;Data;Dendrites;Development;Epigenetic Process;epigenetic profiling;Epitopes;Event;Excision;experimental study;Fellowship;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Regulation;Generations;Genetic;genetic approach;Genetic Transcription;Genomics;Goals;Heterogeneity;hippocampal pyramidal neuron;Immunofluorescence Immunologic;insight;Interneurons;Knock-in Mouse;Knowledge;Laboratories;Lead;Maps;Microscopy;Molecular;mouse genetics;Mus;National Research Service Awards;Neurons;Neurosciences;Pathology;Perception;Phenotype;Physiological;Play;Population;programs;Property;Proteins;Research;Research Personnel;Role;Route;Sensory;Severities;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Somatostatin;Testing;tool;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;Work

PROJECT_TITLE: Molecular Mechanisms of Somatostatin Interneuron Diversity


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Many human diseases, such as cancer and amyotrophic lateral sclerosis (ALS), are linked to mutations and dysfunction of Erythropoietin-producing hepatoma (Eph) receptors. Both the activation mechanism and how mutants contribute to Eph receptor dysregulation are unknown. Here, we will precisely characterize the mechanistic details of Eph receptor function to provide a novel framework for therapeutic development.

PI_NAMEs: WHITEHEAD, BRIANA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Binding;Biochemical;Biological Assay;biophysical techniques;Biophysics;Blood Vessels;Cell Communication;Cell Physiology;Cells;crosslink;Cryoelectron Microscopy;Cutaneous Melanoma;Cysteine;design;Detection;dimer;Dimerization;Disease;Down-Regulation;Drug Design;Drug Targeting;Erythropoietin;extracellular;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Foundations;Functional disorder;Future;gain of function;Goals;human disease;insight;interest;Length;Ligand Binding;Ligands;Link;loss of function;Malignant Neoplasms;MAP Kinase Gene;Membrane;Methods;Modeling;Molecular Conformation;molecular dynamics;Molecular Sieve Chromatography;Morphogenesis;mutant;Mutation;nervous system development;Neurodegenerative Disorders;new therapeutic target;novel;Pathologic;Pathology;Patients;Phosphorylation;Phosphotransferases;Physiological;Play;preservation;Primary carcinoma of the liver cells;Process;receptor;Receptor Activation;receptor function;Receptor Protein-Tyrosine Kinases;Reporting;Role;Sampling;side effect;Signal Pathway;Signal Transduction;Skin;Spectrometry;structural biology;Structure;Testing;theories;Therapeutic;therapeutic development;therapeutic target;Tissues;transmission process;Work

PROJECT_TITLE: Investigating the Mechanism of Activation of EphA4


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Neurosciences;Prevention;Stroke;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

ORG_STATE: CA

PHR: NARRATIVE This research seeks to develop and test the efficacy and implementation of a multi- level, culturally-tailored self-management, nurse-guided intervention comprising of domiciliary self-monitoring of blood pressure, medication reminders and health education information on hypertension, stroke and unhealthy lifestyles delivered via mobile phones for 12 months among recent Ghanaian stroke survivors encountered at 10 hospitals across all the cadres of healthcare. Specifically, this study will test efficacy of a culturally-refined, and potentially scalable intervention aimed at addressing hypertension, the premier modifiable risk for stroke & other key variables in an under- resourced system in Ghana burdened by suboptimal care & outcomes. A secondary objective is to develop an implementation strategy for routine integration and policy adoption of mHealth as a component of a self-management strategy for post-stroke management of hypertension and other cardiovascular risk factors associated with unhealthy lifestyles in resource-limited settings.

PI_NAMEs: OVBIAGELE, BRUCE  (contact);SARFO, FRED STEPHEN

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Academy;Accident and Emergency department;Address;Adherence;Adoption;Adult;adverse outcome;Africa South of the Sahara;Age;Algorithms;American;Anti-Hypertensive Agents;Area;Belief;blood pressure control;blood pressure intervention;Brain Diseases;cardiovascular emergency;cardiovascular risk factor;Cardiovascular system;Caring;Cellular Phone;Chronic;clinical practice;Country;Data;Death Rate;Disease;Effectiveness;effectiveness evaluation;efficacy testing;Etiology;Event;evidence base;experience;Focus Groups;Funding;Ghana;global health;Goals;Health;Health Benefit;Health care facility;Health education;Health Personnel;Health Services Accessibility;Health Technology;Healthcare;high risk;Home Blood Pressure Monitoring;hospital readmission;Hospitals;Hybrids;Hypertension;hypertension control;hypertensive;hypertensives;implementation barriers;implementation context;implementation facilitators;implementation strategy;Improve Access;improved;Incidence;Income;indexing;Intake;Intention;Intervention;Investments;Learning;low and middle-income countries;Measures;Mediator;Medical center;medication compliance;Medicine;mHealth;modifiable risk;Modification;Monitor;mortality;Nurses;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Policies;Population;post stroke;preference;Prevalence;Prevention strategy;primary outcome;programs;Quality of life;Randomized, Controlled Trials;Recurrence;Research;Research Design;Resource-limited setting;Resources;Risk Factors;satisfaction;secondary outcome;Self Efficacy;Self Management;Standardization;Stroke;stroke incidence;stroke patient;stroke risk;stroke survivor;System;systematic review;Techniques;Technology;Telephone;Testing;Text Messaging;Theoretical model;Therapeutic;treatment as usual;underserved area;unhealthy lifestyle;United States;United States National Institutes of Health;usability;usual care arm;vascular risk factor;Work

PROJECT_TITLE: Phone-based Interventions under Nurse Guidance after Stroke II (PINGS II)

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: SAN MARCOS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS STATE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Many alcohol-related health problems (e.g., cirrhosis of the liver) disproportionately affect Latinx Americans, and evidence that Latina women may be disproportionately affected by some alcohol-related health problems (e.g., brain damage) as compared to Latinos is growing, underscoring the public health significance of examining alcohol use among Latinas. To this end, the research proposed in this K01 application will first examine national data to assess patterns of alcohol use and misuse that are the most reflective of the current U.S. Latina population, and next use a sequential mixed methods approach to identify and assess salient and important drinking-related gender role expectations that are endorsed by Latina women. This project seeks to triangulate across distinct and complementary research methods to comprehensively address major gaps in the literature on alcohol use among U.S. Latinas, in an effort to benefit future prevention and treatment programs designed to reduce alcohol-related health disparities in an increasingly at-risk group.

PI_NAMEs: PERROTTE, JESSICA K. (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Acculturation;Address;Affect;Alcohol abuse;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol prevention;alcohol use disorder;Alcohols;American;Area;Attitude;Brain Injuries;Calibration;career;Cirrhosis;clinical practice;Complex;Data;Data Set;Data Sources;design;Development Plans;disparities in women;Disparity;drinking;drinking behavior;Driving While Intoxicated;Drug usage;Elements;Epidemiology;epidemiology study;Ethnic Minority Women;Ethnic Origin;Ethnic Population;expectation;experience;Feminine;Focus Groups;Future;Gender;Gender Role;Glean;Goals;Health;health disparities in women;health disparity;Hispanic-serving Institution;interpersonal conflict;Knowledge;Latin American;Latina;Latina Population;Latino;Latino Population;Latinx;Link;Literature;Liver Cirrhosis;Mainstreaming;Maps;Measures;men;Mentored Research Scientist Development Award;Mentors;Methods;Modernization;Monitor;Movement;Nature;Outcome;Paper;Pattern;Perception;person centered;Phase;Policies;Population;population based;Populations at Risk;Prevalence;Prevention program;Process;professor;programs;Public Health;public health priorities;Qualitative Research;racial minority women;racial population;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Support;Risk;Sampling;sex;Sex Differences;Sex Discrimination;skills;social culture;Societies;sociocultural determinant;sociodemographic factors;statistical center;Surveys;Techniques;tool;Training;Training Activity;transmission process;treatment program;trend;White Women;Woman;Work;young adult

PROJECT_TITLE: Alcohol use and misuse among Latinas in the U.S.: Addressing gaps in the literature with a multi-methods approach

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Triple-negative breast cancer (TNBC) is one of the leading causes of cancer related death in part due to its highly metastatic potential. Given the contribution of epigenetic processes to metastatic potential, this proposal seeks to tackle the need for effective therapeutic strategies to treat TNBC by interrogating the pathways linking prometastatic tyrosine kinase signaling and the chromatin landscape.

PI_NAMEs: COLEMON, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Antitumor Response;ATAC-seq;bone;Brain;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Model;cancer cell;Cancer Etiology;Cell Death;Cell Line;Cell Survival;Cessation of life;Chromatin;Chromatin Remodeling Factor;Clinical Trials;Combined Modality Therapy;CRISPR screen;Data;Drug Targeting;efficacy testing;Enzymes;epigenetic drug;Epigenetic Process;epigenome;experience;experimental study;Family;genetic regulatory protein;Genetic Transcription;Goals;Growth Factor Receptors;Hormones;Human;Impairment;improved;In Vitro;in vitro Assay;in vivo;inhibitor;Invaded;Knowledge;Link;loss of function;Malignant Neoplasms;Metastatic Neoplasm to the Bone;migration;Modification;Molecular;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Pharmacotherapy;Phenotype;Phosphotransferases;Protein Tyrosine Kinase;Relapse;Research;response;Signal Transduction;Site;standard of care;synergism;Therapeutic;therapeutically effective;transcriptome;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor progression;tumor xenograft;Women's mortality

PROJECT_TITLE: Investigating the Impact of ABL Kinase Signaling on Epigenetic Reprogramming in Metastatic Triple Negative Breast Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Human papilloma virus (HPV) has been established as a causative agent of cervical cancer, which disproportionally affects women with HIV in resource-limited countries. While HPV-based screen-and-treat approaches are effective in decreasing cervical cancer, they can lead to overtreatment. By leveraging an ongoing cervical cancer prevention study in a disadvantaged community, we propose herein to study the relationship between HPV, lower genital tract commensal bacteria and fungi, and cervical cancer, as a means to improve cancer screening and follow up after treatment in HIV+ and HIV- women.

PI_NAMEs: UHLEMANN, ANNE-CATRIN  (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Adjuvant Therapy;Africa South of the Sahara;Aftercare;Algorithms;beta diversity;Biological Markers;Biopsy;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;cervicovaginal;cervicovaginal microbiome;Cervix Carcinoma;Cervix Uteri;Cessation of life;Clinical Data;Clinical Research;Collaborations;Colposcopy;commensal bacteria;Communities;Complex;Country;design;Detection;detection sensitivity;Development;Diagnostic;diagnostic screening;Disease;Disparity;Disproportionately impacts women;DNA sequencing;Effectiveness;Enrollment;Environment;Etiology;Excision;Failure;Female;follow-up;fungus;Future;Generations;Genes;Genetic;Genetic Markers;genetic variant;Growth;Health;high risk;HIV;host microbiota;host-microbe interactions;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Immunosuppression;improved;Incidence;Infrastructure;insight;Integration Host Factors;Lactobacillus;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;metagenome;Metagenomics;Methods;Methyltransferase;microbial;microbial community;microbiome;microbiome alteration;microbiota;Molecular;Monitor;Morbidity - disease rate;mortality;Mutagens;neighborhood disadvantage;Nested Case-Control Study;new therapeutic target;Outcome;overtreatment;Participant;Pathogenesis;Patients;Phase;phase 1 study;phase 2 study;Pilot Projects;Play;point of care;Prediction of Response to Therapy;Predictive Value;premalignant;prevent;Primary Prevention;Productivity;prophylactic;Rapid diagnostics;Recurrence;Recurrent disease;reproductive tract;Research Support;Resources;Ribosomal RNA;Risk;Role;Safety;Sampling;screening;Screening for cancer;screening program;South Africa;South African;Subgroup;Swab;tertiary prevention;Test Result;Testing;Therapeutic;Time;Toxin;Treatment Failure;treatment response;Triage;tumor progression;Universities;unnecessary treatment;Vagina;vaginal microbiome;Variant;Viral;Virus;Woman;Women's mortality;Work

PROJECT_TITLE: The role of the microbiome in HPV-associated cervical cancer in women with HIV


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This clinical trial will compare the effectiveness, safety, and implementation feasibility of comprehensive, intensive behavioral counseling vs. medical management plus relatively low-intensity behavioral counseling among adolescents with severe obesity.

PI_NAMEs: KELLY, AARON S (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Adherence;Adolescent;Adolescent obesity;adolescent patient;Adverse event;Advisory Committees;Age;Agonist;arm;behavior change;Behavior Therapy;Behavioral;Biological;Body fat;Body mass index;Body Weight decreased;bone health;cardiometabolic risk;Clinical;Clinical Practice Guideline;Clinical Trials;Combination Drug Therapy;compare effectiveness;cost;cost effective;cost effectiveness;Counseling;Development;Disease;Effectiveness;Enrollment;Family;Food;gastrointestinal;GLP-I receptor;Health;Healthcare;Healthcare Systems;Homeostasis;Hormones;Hour;implementation evaluation;improved;increased appetite;Individual;Intervention;liraglutide;maladaptive behavior;Medical;Mental Health;moderate obesity;Morbid Obesity;Nature;Obesity;Outcome;Outcome Assessment;Patients;pediatric patients;Pharmacotherapy;Physiological;Population;Prevalence;Preventive service;primary outcome;Process;psychosocial;Puberty;Quality of life;Randomized;randomized, clinical trials;Recommendation;Refractory;Reporting;Resistance;Resources;Risk Factors;Safety;safety outcomes;screening guidelines;Services;success;System;Time;treatment strategy;Uncertainty;United States Preventative Services Task Force;Update;Weight maintenance regimen;Youth

PROJECT_TITLE: Comparison of Intensive Behavioral Counseling vs. Medical Management to Treat Adolescent Severe Obesity

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: This project proposes to better understand racial/ethnic and geographic disparities of colorectal cancer outcomes through establishment of a colorectal cancer survivor cohort containing pre- and post-diagnosis built environment exposure histories. The survivor cohort will enable investigation of numerous relationships between race/ethnicity, pre- and post-diagnosis built environment factors, colorectal cancer prognostic indicators (microsatellite instability testing, subsite, grade, stage at diagnosis), and colorectal cancer survival. The existence and magnitudes of these relationships can motivate various actions, such as inclusion of built environment assessments within central cancer registries for enhanced cancer surveillance and motivation of municipal policies that impact built environments.

PI_NAMEs: PLASCAK, JESSE JOHN (contact)

PROGRAM_OFFICER_NAME: CRONIN, KATHLEEN A

PROJECT_TERMS: Address;Black Populations;built environment;cancer health disparity;Cancer Prognosis;cancer survival;Cancer Survivor;Characteristics;cohort;Colon Carcinoma;Colorectal Cancer;data registry;deprivation;Diagnosis;Disease;Disparity;Emerging Technologies;Environment;Environmental Risk Factor;epidemiology study;ethnic disparity;Ethnic Origin;Ethnic Population;ethnic segregation;Exposure to;geographic disparity;Geographic Factor;Geography;Health;Health Insurance;Healthcare;Individual;innovation;Investigation;Location;Malignant Neoplasms;Mediating;Mediation;Methodology;Methods;Microsatellite Instability;model building;mortality;Motivation;Municipalities;Neighborhoods;neoplasm registry;New Jersey;Not Hispanic or Latino;novel;Outcome;Pattern;Policies;Population-Based Registry;prevent;Prognostic Factor;prognostic indicator;Protocols documentation;public health intervention;Race;racial disparity;racial population;Recording of previous events;Records;Rectal Cancer;Registries;Reporting;residence;Residential Mobility;Risk Factors;Role;social;socioeconomics;spatiotemporal;Stage at Diagnosis;surveillance data;Survivors;System;Test Result;Testing;Time;tumor;Variant;virtual;walkability

PROJECT_TITLE: Time-varying relationships between built environment factors, colon and rectum cancer prognosis, and survival

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Estrogen;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Males and females experience both different outcomes and symptomatology following traumatic brain injury (TBI). It is currently unknown whether injury-induced changes in sex hormones underlie these differences. This study will yield novel mechanistic insight into how high or low estrogen at time of injury modulates initial injury severity and how hormonal dysfunction following TBI affects the development of sex-specific symptomatology.

PI_NAMEs: GRECO, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Affect;Affective;Amenorrhea;antagonist;Anxiety;Behavior;biopsychosocial;Caring;Cell Death;Cerebrovascular Circulation;Cerebrum;Chronic;chronic pain;Clinical;Clinical Research;combat;Consensus;contact sports;Corticosterone;Corticotropin-Releasing Hormone;Coupling;Data;Data Analyses;Data Reporting;Development;Drug Metabolic Detoxication;duloxetine;Enrollment;Enzymes;Estradiol;Estrogen Receptor 2;Estrogens;Estrus;Etiology;Excitatory Amino Acids;Exclusion;expectation;experience;Female;female sex hormone;Free Radicals;Functional disorder;Gender;glucose metabolism;glucose transport;Glycolysis;Gonadal Steroid Hormones;gray matter;Hormonal;hormone regulation;Hormones;Hospitalization;Impairment;improved outcome;Incidence;Inflammation;inhibitor;Injury;insight;interest;Intervention;Knowledge;Learning;male;Measurement;Measures;Mediating;men;Menstrual cycle;Mental Depression;Metabolic;Metabolism;Military Personnel;Mitochondria;Monitor;Mood Disorders;Moods;mortality;neuronal circuitry;Neuronal Plasticity;neuroprotection;neurotransmission;Nociception;Norepinephrine;novel;Outcome;Outcome Measure;Oxidative Phosphorylation;Pain;Pain Disorder;Pathway interactions;Pattern;Phase;Physiological;Play;pre-clinical;preclinical study;Predisposition;prevent;Production;Proestrus;Quality of life;Reactive Oxygen Species;Recovery;Regulation;reproductive hormone;Research;reuptake;Role;Secondary to;Serotonin;Severities;sex;Sex Differences;Signal Transduction;Stress;symptomatology;Symptoms;targeted treatment;Therapeutic Intervention;Time;timeline;transmission process;Traumatic Brain Injury;treatment strategy;Woman;Women's study;Work

PROJECT_TITLE: Cerebral Mechanisms of Vulnerability Following Female Traumatic Brain Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Diabetes affects a large number of people in the US, and increases the risk of chronic complications including cardiovascular disease, blindness, kidney failure, and non-traumatic extremity amputations. Obesity is even more common, and is associated with an increase in the risk of type 2 diabetes as well as cardiovascular disease and multiple additional morbidities. The University of Maryland Baltimore has established this institutional research training program to train the next generation of biomedical scientists to conduct innovative research to address the high degree of high unmet medical need due to diabetes and obesity.

PI_NAMEs: TAYLOR, SIMEON I. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Metabolic;Obesity

PROJECT_TITLE: Diabetes, Obesity, and Metabolic Complications


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Cancer therapies based on stimulating the patient's immune system represent an important treatment modality, but much remains to be discovered to overcome tumor-induced T cell dysfunction that often limits the long-term tumor control. Our effort has focused to devise the culture conditions that program not only CD4+ T cells but also CD8+ T cells to express unique effector features exhibited by Th1 (or Tc1) and stemness phenotype of Th17 (or Tc17) – in order to generate superior hybrid phenotype anti-tumor T cells. The studies proposed in this application will determine the underlying mechanisms, in terms of epigenetic and metabolic signature of these hybrid T cells, which lead to durable long-term tumor control upon adoptive transfer in pre- clinical mouse models.

PI_NAMEs: MEHROTRA, SHIKHAR  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acetylation;Adoptive Cell Transfers;Adoptive Transfer;Aging;anti-PD1 antibodies;Antibodies;Antigens;Antitumor Response;Autologous;Biological Process;Calcium;cancer infiltrating T cells;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death;Cells;Chromatin;Clinical;clinical practice;cofactor;combinatorial;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Deacetylation;Dependence;ecto-nucleotidase;Energy Metabolism;engineered T cells;Epigenetic Process;epigenome;Epitopes;Equilibrium;Event;exhaustion;Exhibits;Failure;FOXP3 gene;Functional disorder;genetic signature;Glutamine;Helper-Inducer T-Lymphocyte;Histone Deacetylase;Homeostasis;Human;Human Engineering;Hybrids;Hydrolase;IL17 gene;IL2 gene;Immune system;Immunotherapy;improved;improved outcome;in vivo;infectious disease model;Interferon Type II;Investigation;Lead;Learning;Malignant Neoplasms;Mediating;Memory;Metabolic;metabolic profile;Metabolism;Methylation;mitochondrial metabolism;Modality;Modification;Molecular;mouse model;Mus;neoplasm immunotherapy;Nicotinamide adenine dinucleotide;novel;Patients;PD-1 blockade;Phenotype;Post-Translational Protein Processing;PPBP gene;pre-clinical;preclinical study;preservation;Primary Neoplasm;programmed cell death protein 1;programs;Property;Proteins;Protocols documentation;Publishing;receptor;Regulation;Regulatory T-Lymphocyte;Rejuvenation;Reporter;Reporting;response;Role;SIRT1 gene;Sirtuins;Solid Neoplasm;stem cell fate;stemness;T cell response;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;TC1 Cell;Testing;Th1 Cells;TNF gene;transcriptome sequencing;Transferase;Translating;tumor;tumor growth;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work;Xenograft Model

PROJECT_TITLE: Understanding Metabolic and Epigenetic Cross‐ talk in Potent Anti‐ tumor T cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Proper control of gene expression is fundamentally important for the life and development of all organisms. In all eukaryotes, proteins that regulate transcription, a central step in gene expression, operate within the constraints of a chromatin environment that must be properly managed for gene expression to occur without error. This research program will uncover the functions of the Paf1 complex and other conserved proteins in regulating chromatin structure and transcription --- core cellular processes that, when deregulated, cause a multitude of human health conditions, including cancer and developmental defects.

PI_NAMEs: ARNDT, KAREN M (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Biochemistry;Cell Physiology;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chromatin Structure;Compensation;Complex;Coupled;Defect;Development;Disease;Environment;Epigenetic Process;Eukaryota;Eukaryotic Cell;Event;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomics;Goals;Health;histone modification;Human;innovation;Life;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Modification;Molecular;Nature;Nucleosomes;Organism;pancreatic differentiation 2 protein;Pathway interactions;Pattern;Polymerase;Positioning Attribute;Post-Translational Protein Processing;Process;programs;Property;Proteins;Proteomics;Research;RNA chemical synthesis;RNA Polymerase II;Saccharomyces cerevisiae;System;tool;Transcription Elongation;Transcriptional Elongation Factors;Work

PROJECT_TITLE: Mechanisms that Couple Chromatin Modifications to Transcription

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: PORTLAND

ORG_NAME: NATIONAL UNIVERSITY OF NATURAL MEDICINE

ORG_STATE: OR

PHR: With the increasing public use of complementary and integrative health (CIH) modalities and  disciplines, rigorous research is essential so that CIH therapies can be accurately evaluated, and  members of the public adequately informed. To help meet the need to rigorously evaluate  promising CIH treatments for treating disease and improving health, CIH clinicians need  training in clinical and translational research methods, and conventionally trained researchers  need grounding in CIH therapies and philosophies. The T90/R90 BRIDG program partnership  between the University of Washington and the National University of Natural Medicine is preparing  the next generation of clinical investigators to design and carry out competitive,  rigorous programs of CIH research that are innovative, collaborative, and  multi-disciplinary, thereby generating new knowledge and contributing to improving health  care.

PI_NAMEs: BRADLEY, RYAN D;ZWICKEY, HEATHER LEA (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Applications Grants;Archives;Chinese Traditional Medicine;Clinical;Clinical Clerkship;Clinical Investigator;clinical practice;Clinical Research;Collaborations;Complementary Health;Data;Dedications;design;Development;digital;Discipline;Distance Education;Distance Learning;Doctor of Philosophy;E-learning;education research;Educational workshop;experience;Fostering;Funding;hands on research;health training;Healthcare;Herbal Medicine;improved;innovation;Institution;Integrative Medicine;interest;Knowledge;Learning;Learning Module;Medicine;Mentors;Mentorship;Methods;mind/body;Modeling;multidisciplinary;Naturopathy;next generation;Participant;Persons;Postdoctoral Fellow;preservation;programs;Research;Research Methodology;Research Personnel;Research Training;success;Training;Training Programs;Universities;Washington

PROJECT_TITLE: Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Recent work from our group has demonstrated that PRDM10, a member of the PRDM family of transcription factors, is essential in early embryogenesis leading to developmental arrest, and defects in the translation machinery. Given the expression of PRDM10 in the oocyte and its essential function as a maternal-effect gene, here we propose to investigate the function, at the mechanistic level, of PRDM10 at early stages of mammalian development. This work will greatly expand our knowledge on basic developmental processes and on the epigenetic, transcriptional and translational regulation of early embryogenesis, with future implications for reproductive biology.

PI_NAMEs: GUCCIONE, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Adult;Aging;Apoptosis;AT Rich Sequence;Automobile Driving;Binding;Biological Models;Catalytic Domain;Cell Cycle Progression;Cell Physiology;Cells;Chromatin;Chromatin Structure;Communication;Complex;Couples;Cues;Data;Defect;Developed Countries;Development;Developmental Process;Diagnosis;Disease;DNA;DNA Binding;DNA Binding Domain;Drops;Embryo;Embryonic Development;embryonic stem cell;epigenetic regulation;Event;experimental study;extracellular;Family;Family member;Family Planning;Fertility;Fingers;Future;Gene Activation;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;Germ Cells;Glutamine;Herpes zoster disease;idiopathic infertility;Infertility;inhibitor;Knowledge;Link;Lysine;Malignant Fibrous Histiocytoma;member;Methyltransferase;Mitotic;Modeling;Mus;Nature;Oncogenic;Oocytes;Oogenesis;paralogous gene;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Pre-implantation Embryo Development;Pregnancy Complications;Process;programs;promoter;Property;protein expression;Proteins;Reproductive Biology;Reproductive Medicine;Research;Role;Science;SET Domain;side effect;Signal Transduction;Societies;Soft tissue sarcoma;Specific qualifier value;stem cell biology;Time;Tissues;Transcription Coactivator;transcription factor;Transcriptional Activation;Transcriptional Regulation;Translational Regulation;Translations;Vertebrates;Work;zygote

PROJECT_TITLE: FUNCTIONAL CHARACTERIZATION OF THE PRDM10-ZN FINGER TRANSCRIPTION FACTOR IN EARLY MAMMALIAN DEVELOPMENT

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The 60 million rural residents of the United States have a lower rate of new cases of cancer per year compared to urban residents but have a higher rate of cancer deaths per year, partly due to the greater difficulty in accessing high-quality cancer treatment in rural areas. As rural patients are less likely to receive care in urban cancer centers with cancer specialists who treat very large numbers of cancer patients, an effective strategy used by the University of Kentucky Markey Cancer Center has been to share their expertise and resources with smaller community hospitals across Kentucky to help improve their quality of care. We propose to study the Kentucky model in order to identify and characterize its core functions (i.e., what made it effective in improving quality of care in community hospitals), adapt it to a new rural setting, and determine its value to the hospitals and impact on cancer care.

PI_NAMEs: CHARLTON, MARY E. (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Accreditation;adaptation algorithm;Address;Adopted;Adoption;American College of Surgeons;Area;Breast;breast cancer diagnosis;Breast-Conserving Surgery;cancer care;Cancer Center;Cancer Death Rates;cancer health disparity;Cancer Patient;cancer therapy;cancer type;Caring;Colon Carcinoma;Colorectal;Colorectal Cancer;Community Hospitals;Consolidated Framework for Implementation Research;cost;Data;Data Collection;data registry;Death Rate;Diagnosis;Diffusion;disparity reduction;draining lymph node;Effectiveness;evidence base;Familiarity;Goals;Guidelines;health difference;Health system;Healthcare;Home;hospital care;Hospitals;implementation determinants;implementation outcomes;implementation process;implementation science;improved;Incidence;Infrastructure;Intervention;Intervention Trial;Interview;Iowa;Kentucky;Logistics;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Methods;Modeling;Monitor;mortality;multidisciplinary;Needs Assessment;neoplasm registry;network models;novel;Outcome;Patients;Pattern;Performance;Physicians;Population;post intervention;preference;preservation;Proctor framework;programs;psychosocial;Qualifying;Quality of Care;Radiation therapy;Readiness;Research;Resected;Resource Sharing;Resources;Risk;Rural;rural area;rural cancer care;rural disparities;rural dwellers;Rural Hospitals;rural patients;Rural Population;rural setting;Services;Social support;Specialist;Specific qualifier value;Structure;survival outcome;survivorship;Testing;theories;Time;tool;Transportation;treatment guidelines;treatment planning;United States;Universities;Urban Population;Woman;Work

PROJECT_TITLE: Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Prevention;Rural Health

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Increasing evidence from animal studies and humans suggests that exposures to environmental insults during fetal development can promote adverse health outcomes that persist transgenerationally by mechanisms that remain unknown. Mouse prenatal exposure to polybrominated biphenyls (PBBs), a flame retardant that people in rural Michigan were highly exposed to in the 1970s, leads to reproductive phenotypes in mouse descendants that mirror those observed in affected Michigan populations, and results in transgenerationally persistent newly accessible transcription factor (TF) footprints in the mouse sperm chromatin. The proposed project will assess the molecular makeup of transgenerationally persistent PBB-induced TF footprints in sperm, the genomic distribution of these sites in oocytes, and the fate of these epimutations from the gametes to the E6.5 postimplantation embryo, when the germline is specified.

PI_NAMEs: RUIZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adipose tissue;Adult;Affect;Androgen Receptor;Animals;ATAC-seq;Binding;Binding Sites;bisphenol A;bisulfite sequencing;cancer type;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Daughter;Development;Disease;disorder prevention;DNA;DNA Methylation;early experience;Ectoderm;Embryo;embryo cell;Enhancers;Environment;environmental chemical;Epiblast;Epigenetic Process;epigenome;experimental study;Exposure to;Female;Fertilization;Fetal Development;Flame Retardants;Functional disorder;Gene Expression;Generations;Genes;genome-wide;Genomic Segment;Genomics;Germ Cells;Germ Lines;girls;Goals;Health;histone modification;Histones;Human;in utero;Individual;Inherited;Knowledge;Livestock;Mammals;Mediator;Michigan;Modeling;Modification;Molecular;Mothers;mouse model;Mus;natural Blastocyst Implantation;neuronal cell body;Neurons;novel;Nuclear Hormone Receptors;Nucleosomes;Obesity;offspring;Oocytes;Outcome;Persons;Phenotype;Polybrominated Biphenyls;Population;Pregnancy;prenatal exposure;prevent;Preventive care;Process;Proteins;Puberty;Registries;reproductive;reproductive outcome;Rural;rural area;rural dwellers;Rural Population;single cell technology;Site;Specific qualifier value;sperm cell;Structure of primordial sex cell;Testing;Time;transcription factor;transgenerational epigenetic inheritance;transmission process;Variant;Work;zygote

PROJECT_TITLE: Mechanisms of transgenerational epigenetic alterations induced by polybrominated biphenyls

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Variation in epidermal pigmentation, one of the most striking features of modern humans, is critical for protection against the harmful effects of ultraviolet radiation and is altered in melanomas and many genetic diseases. The goal of this proposal is to identify genetic variants associated with skin pigmentation in a unique cohort of ethnically diverse Africans with varied skin tones. We will then determine how the sequence variations impact the expression of the associated genes, and identify the molecular and cellular mechanisms by which these genes modulate pigmentation within skin cells.

PI_NAMEs: MARKS, MICHAEL S (contact);OANCEA, ELENA ;TISHKOFF, SARAH ANNE

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;African;Animal Model;Biological Assay;Biology;Candidate Disease Gene;candidate identification;Carrier Proteins;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;Chromatin;Code;cohort;Collaborations;CRISPR/Cas technology;Cytoplasm;Data;Data Set;Disease;enzyme activity;ethnic diversity;Ethnic Population;European;G-Protein-Coupled Receptors;gene discovery;Gene Expression;gene product;Genes;Genetic;genetic analysis;Genetic Diseases;genetic variant;Genetic Variation;Genome;genome wide association study;Genomic Segment;Genomics;Goals;GTP-Binding Proteins;Hair;Human;Human Genetics;Hypersensitivity skin testing;Ion Transport;Knowledge;Link;Luciferases;Lysosomes;Maps;Melanins;Melanocortin 1 Receptor;melanocyte;Melanogenesis;Melanoma;Melanosomes;Membrane;Membrane Transport Proteins;Metastatic Melanoma;Microscopy;migration;Modernization;Molecular;Molecular Mechanisms of Action;Mus;Mutagenesis;Natural Selections;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Organelles;patch clamp;Pathologic;Phenotype;Physiological;Pigmentation physiologic function;Pigments;Population;Production;Prognosis;Protein Subunits;Proteins;Publishing;rare genetic disorder;receptor;Receptor Signaling;receptor-mediated signaling;Regulatory Element;Risk;Sample Size;Scanning;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Skin;Skin Pigmentation;SNP array;solute;success;Testing;trafficking;trait;Ultraviolet Rays;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Genetic and molecular basis for variation in human skin pigmentation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Glutamate, the major excitatory neurotransmitter in the brain, acts at 8 metabotropic glutamate (mGlu) subtypes, expressed in a partially overlapping fashion in distinct brain circuits. Evidence indicates that specific mGlu receptor protomers can heterodimerize and exhibit dramatically different pharmacology when compared to their homomeric counterparts. Our preliminary evidence supports the presence of a heteromer of mGlu7 and mGlu8 in the hippocampus, and we will pursue electrophysiological, genetic, and pharmacological approaches to support this hypothesis, building toward more selective ligand modulation of mGlu receptor biology in the brain.

PI_NAMEs: JAVITCH, JONATHAN A (contact);NISWENDER, COLLEEN M

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: addiction;Agonist;Area;Attention;Binding;Biology;Brain;brain tissue;Cells;Clinical Trials;Complement;Corpus striatum structure;Data;dimer;Electrophysiology (science);Energy Transfer;Exhibits;gamma-Aminobutyric Acid;Genetic;Glutamate Agonist;Glutamates;Heterodimerization;Hippocampus;Homo;In Vitro;in vivo;Intervention;Knock-out;Knockout Mice;Knowledge;Lead;Ligands;Long-Term Potentiation;Mediating;Mental Depression;Metabotropic Glutamate Receptors;Molecular;Mus;neuronal circuitry;Neurons;Neurotransmitters;novel;optogenetics;Parkinson Disease;pharmacologic;Pharmacology;Phenotype;positive allosteric modulator;Property;Protomer;receptor;Receptor Activation;Reporting;research clinical testing;response;Signal Transduction;Slice;Synapses;Techniques;Testing;tool;Transactivation;Translating;Transmembrane Domain

PROJECT_TITLE: Impact of metabotropic glutamate receptor heteromerization on signaling and pharmacology

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE To understand the effectiveness and implementation of the SCP-PHR, we will conduct a hybrid type 1 effectiveness-implementation trial consisting of the following components: (A) a randomized clinical effectiveness trial, and (B) a mixed methods implementation study.

PI_NAMEs: HAGGSTROM, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: Anxiety;Attention;Attitude;Blood Tests;cancer care;Cancer Detection;Cancer Patient;cancer recurrence;Cancer Survivor;cancer therapy;cancer type;Carcinoembryonic Antigen;care delivery;care systems;Caregivers;Caring;Client satisfaction;Clinical;Colonoscopy;Colorectal Cancer;contextual factors;cost;Data;design;Disabling;Effectiveness;effectiveness clinical trial;effectiveness/implementation trial;Fatigue;follow-up;Foundations;Frequencies;Guidelines;Health;health information technology;Health Personnel;Health Planning;health record;Healthcare;Hybrids;implementation barriers;implementation science;implementation strategy;implementation study;implementation trial;improved;indexing;Individual;Information Systems;Institute of Medicine (U.S.);Internet;Interview;Knowledge Management;Long-Term Care;Malignant Neoplasms;Measurement;Measures;Medical;Mental Depression;Methods;neoplasm registry;Online Systems;Outcome;Pain;Participant;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;Pattern;Personal Health Records;Physicians;population based;Population Study;Prevention;Preventive;Preventive care;Primary Care;Primary Prevention;Process;process evaluation;Quantitative Evaluations;Randomized;Recommendation;recruit;reduce symptoms;Reporting;Research;Research Design;Role;screening;Self Management;Severities;Sleep;Software Tools;Structure;survivorship;symptom management;Symptoms;systematic review;Technology;Testing;tool;treatment as usual;Twin Multiple Birth;United States Preventative Services Task Force;usability;Visit;web site;X-Ray Computed Tomography

PROJECT_TITLE: SPHERE (Survivorship Plan Health Record) Implementation Trial

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative  This proposal seeks to advance our understanding and treatment of coronary microvascular disease (CMD) through the development of new imaging methods and their use investigating underlying cellular and molecular disease mechanisms (in mouse models), and in the evaluation of pharmacological therapy (in mice and humans). Specifically, we will develop MRI methods to quantify the fatty acid composition of epicardial adipose tissue, use multiparametric MRI applied in a mouse model to elucidate the roles of the fatty acid composition and M1-polarized macrophages in CMD, and, in mice and humans, investigate a role of SGLT2 inhibition for the treatment of CMD.

PI_NAMEs: EPSTEIN, FREDERICK H (contact);WOLF, MATTHEW J

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acceleration;Accounting;Address;Adenosine;Adipose tissue;Anti-Inflammatory Agents;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;Cells;clinical effect;Coronary;Coronary Arteriosclerosis;Data;Development;Diabetes Mellitus;Dictionary;Diet;Endothelium;Engineering;Evaluation;Event;Exhibits;FAT gene;Fatty acid glycerol esters;Fatty Acids;Female;Gender;Gene Modified;high risk;Human;human subject;Image;imaging modality;imaging Segmentation;Impairment;improved;in vivo;Inflammation Mediators;Inflammatory;inhibitor;Investigation;Knock-out;Least-Squares Analysis;Link;Lipids;Macrophage;Magnetic Resonance Imaging;Maps;Mediator;Metabolic syndrome;Methods;Microcirculation;Microvascular Dysfunction;Modeling;Molecular;Molecular Disease;mortality;mouse model;Mus;Myocardial;Myocardial Ischemia;Myocardial perfusion;Myocardium;N-3 polyunsaturated fatty acid;NMR Spectroscopy;novel marker;Obesity;Oxidative Stress;Patients;pharmacologic;Play;Positron-Emission Tomography;pre-clinical;preclinical study;preservation;primary endpoint;Protocols documentation;Protons;Reference Standards;Resolution;Rest;Role;Saturated Fatty Acids;Signal Transduction;Sucrose;System;Testing;Tissues;Transgenic Organisms;Triglycerides

PROJECT_TITLE: Multiparametric MRI for the investigation of coronary microvascular disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Peripheral nerve injuries (PNIs) account for approximately 3% of trauma cases in the clinic, which translates into an expenditure of approximately 150 billion dollars spent in annual care due to the increased morbidity and decrease in the patient’s quality of life caused by PNIs. An alternative to promote nerve regeneration across an injured nerve resulting in a gap are Acellular Nerve Allografts (ANAs), which are processed allogenic nerves that promote regeneration across short gaps (< 3 cm) but fail to promote regeneration across longer gaps (> 3 cm). The goal of this research is to identify and compare the subpopulations of cells inside short and long ANAs and autografts, identify the cells promoting the inflammatory microenvironment in long ANAs, and reduce inflammation in long ANAs to observe the effects of decreasing inflammation on axonal regeneration and to further develop therapies promoting nerve regeneration across long ANAs.

PI_NAMEs: ACEVEDO CINTRÓN, JESÚS ALBERTO (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affect;Allogenic;Allografting;angiogenesis;Autologous Transplantation;Axon;axon regeneration;Biomedical Engineering;Blood Vessels;Caring;cell motility;Cells;Chemicals;Chronic;Clinic;Clinical;cytokine;Data;Defect;Detergents;Expenditure;experience;Extracellular Matrix;Fellowship;FK506;Gene Expression;Goals;Harvest;immunogenicity;Immunology;Immunosuppressive Agents;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;inflammatory modulation;Inflammatory Response;Injury;Intervention;Knowledge;Learning;Length;Macrophage;Measures;migration;Modeling;Modification;Molecular Target;Morbidity - disease rate;Morphology;myelination;Natural regeneration;Nerve;nerve autograft;nerve damage;nerve gap;nerve injury;Nerve Regeneration;nerve repair;Neurobiology;novel;Operative Surgical Procedures;Patients;Peripheral nerve injury;Peripheral Nerves;pharmacologic;Process;Quality of life;Rattus;reconstruction;Recovery of Function;regeneration potential;regenerative;repaired;Research;Role;sciatic nerve;Scientist;single-cell RNA sequencing;Site;standard of care;T-Lymphocyte;Tacrolimus;Techniques;Testing;therapy development;Time;Training;Translating;Trauma;United States

PROJECT_TITLE: The role of the inflammatory microenvironment in Acellular Nerve Allografts (ANAs) repairing nerve gaps


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  This proposed research is relevant to woman’s health and overall public health by implementing a specialized breast screening simulation system within radiology residency to study the interpretation and perception skills that occur over time. These findings will aid in developing tools that can avert or correct interpretation errors early in resident education to reduce missed cancers and unnecessary additional imaging and biopsies. Thus, this proposal is relevant to the NIH’s mission to improve the accuracy of breast cancer detection through training and education.

PI_NAMEs: SALKOWSKI, LONIE  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: American College of Radiology;Applications Grants;Architecture;Benign;Biopsy;Breast;Breast Cancer Detection;breast imaging;calcification;Cancer Detection;Characteristics;Clinic;Clinical;Cognition;Cognitive;computer science;Continuing Education;cost;Data;density;Detection;Development;Discrimination;Education;Educational Psychology;Evaluation;experience;Faculty;Feedback;Fellowship;General Practitioners;Goals;high risk;Image;imager;improved;Individual Differences;innovation;insight;Intelligence;Judgment;Learning;Legal patent;Lesion;Liquid substance;Machine Learning;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Measures;Mission;Outcome;Patient Care;Patient-Focused Outcomes;Perception;Performance;Personality Traits;Physicians;Positioning Attribute;Preparation;processing speed;programs;Psychology;Public Health;radiologist;Radiology Specialty;Reading;Research;Research Proposals;Residencies;Resources;Risk;screening;Short-Term Memory;simulation;skill acquisition;skills;Societies;Specialist;stem;Surveys;System;Testing;Time;Time Perception;tool;Training;Training and Education;United States;United States National Institutes of Health;visual tracking;Women's Health

PROJECT_TITLE: Defining and Optimizing Critical Interpretation Skills in Screening Mammography to Improve Cancer Detection


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The proposed study addresses an important and under-investigated area of treating atrial fibrillation using a completely fluoroless approach with ICE imaging. The proposed research is significant since it will allow for better therapeutic outcomes by reducing recurrence rates and complications associated with cardiac ablation, and avoiding exposure of the patient and clinical care team to X-ray radiation.

PI_NAMEs: JAGADEESAN, JAYENDER  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adopted;Adoption;Algorithms;Anatomy;Area;Arrhythmia;Atrial Fibrillation;Canada;cancer risk;Cardiac;Cardiac ablation;Catheters;clinical care;Computer software;Computer Vision Systems;convolutional neural network;Coupling;deep learning algorithm;design;design verification;dexterity;Diagnosis;Early Diagnosis;Echocardiography;Ensure;Esophageal Fistula;Family suidae;Fluoroscopy;Goals;Grant;Heart;Heart Atrium;Hospitals;Image;image guided;image registration;innovation;instrument;Intuition;Ionizing radiation;kinematics;Lesion;light weight;Machine Learning;machine learning algorithm;machine vision;Manuals;Maps;Medical;Microbubbles;Modeling;Monitor;Myocardium;Navigation System;Necrotic Lesion;novel;Ontario;Operative Surgical Procedures;Patient Care;Patients;Perforation;Performance;phantom model;porcine model;Positioning Attribute;Procedures;Pulmonary veins;Radial;radio frequency;real time monitoring;Recurrence;Research;Research Personnel;Risk Reduction;Robot;robot assistance;Robotics;Roentgen Rays;Surgical Instruments;System;Technology;therapy outcome;Thrombus;Time;time use;ultrasound;United States;Universities;Vision;Visualization;Woman;Work

PROJECT_TITLE: Robot-Assisted 3D ICE Catheter for Cardiac Ablation


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Human Genome;Immunotherapy;Pediatric;Precision Medicine;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Anti-thymocyte globulin (ATG), an immunotherapy, preserves β-cell function in type 1 diabetes (T1D). However, not all treated individuals boast a similar response, necessitating immune characterization of these clinical “responders”. Identification of a response signature could be applied to future clinical trial enrollment criteria—to personalize care and direct patients to an immune therapy with the highest likelihood of success (β-cell preservation).

PI_NAMEs: JACOBSEN, LAURA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: adaptive immune response;Algorithms;alpha-beta T-Cell Receptor;Antithymoglobulin;Area Under Curve;arm;Autoimmune Diseases;Beta Cell;Big Data Methods;Biological Assay;Biological Markers;C-Peptide;career;Career Choice;career development;CD4 Positive T Lymphocytes;Cell Death;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Childhood;Clinical;clinical care;clinical efficacy;clinical trial enrollment;Clinical Trials;Clinical Trials Design;Complex;Coupled;CSF3 gene;Data;Defect;Development;Development Plans;differential expression;Disease;Dose;Endocrinologist;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenetic profiling;exhaust;exhaustion;Florida;Flow Cytometry;Frequencies;Funding;Future;Genes;Genetic;Genetic Predisposition to Disease;Genomics;Glycosylated hemoglobin A;Goals;Heterogeneity;Human;Immune;immune function;Immune Tolerance;immunological intervention;Immunology procedure;immunomodulatory therapies;Immunophenotyping;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo evaluation;Individual;individual patient;Innate Immune Response;innovation;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Trial;Knowledge;Manuscripts;Measures;Mediating;Methodology;Methylation;methylome;Mission;next generation;Outcome Assessment;Outcome Measure;Patient Selection;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;personalized care;personalized therapeutic;Pharmaceutical Preparations;Phenotype;Physicians;Placebos;Play;precision medicine;predicting response;predictive marker;Preparation;preservation;primary outcome;Production;prospective;Regulatory T-Lymphocyte;Research Personnel;response;response biomarker;responsible research conduct;Role;Sampling;Scientist;side effect;single cell analysis;single-cell RNA sequencing;skills;Structure of beta Cell of islet;Subgroup;success;Surface;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;Training;Transcript;transcriptome;transcriptomic profiling;transcriptomics;treatment optimization;treatment response;trial enrollment;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Development of a Predictive Response Signature to Anti-Thymocyte Globulin in Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Development of the models proposed in this application will contribute to the unmet need for accurate, broadly accessible stratification tools to enhance precision medicine for colorectal cancer (CRC). Public availability of our models and de-identified dataset will enhance future machine learning–based CRC research by other investigators. Finally, these resources and models are readily extendable to other cancer types.

PI_NAMEs: SHEN, JEANNE  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adjuvant Therapy;anti-cancer research;Architecture;Area;Biological Markers;biomedical data science;cancer biomarkers;Cancer Etiology;cancer surgery;cancer type;Catalogs;Cessation of life;chemotherapy;Clinical;Clinical Data;Clinical Medicine;cohort;Collaborations;colon cancer patients;Colorectal Cancer;Companions;computer science;Computerized Medical Record;cost;cost efficient;Data;data de-identification;data fusion;data modeling;Data Set;data sharing;deep learning;deep learning model;Deposition;Development;Diagnosis;Diagnostic;Disease;Disease-Free Survival;electronic structure;empowerment;Ensure;Evaluation;Excision;follow-up;Future;Health Care Costs;high risk;Human;Image;imaging study;improved;Institution;Laboratories;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant Neoplasms;Methods;Modality;Modeling;Morbidity - disease rate;mortality;multimodal data;multimodal learning;multimodal modeling;multimodality;novel;Oncologist;Oncology;online repository;Operative Surgical Procedures;Outcome;overtreatment;Pathologic;Pathologist;Pathology;pathology imaging;Patient Triage;Patients;Performance;Pharmaceutical Preparations;Physicians;precision medicine;Precision therapeutics;primary outcome;prognostic;prognostic assays;prognostication;radiological imaging;radiologist;Radiology Specialty;Records;Recurrence;Research;Research Personnel;Resectable;Resources;Risk;risk stratification;Secure;standard of care;statistics;Stratification;Structure;Testing;Time;tool;Training;treatment planning;Treatment-related toxicity;tumor;unnecessary treatment;Validation;whole slide imaging;X-Ray Computed Tomography

PROJECT_TITLE: Multi-modal machine learning to guide adjuvant therapy in surgically resectable colorectal cancer

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Caspases control whether cells live or die by apoptosis and are critical factors in neurodegener- ation and other diseases, making a full understanding of their roles and regulation pivotal in pharmaceutical development. Our work over the past two decades has focused on understand- ing caspase regulation at a structural level and has resulted in development of the most selec- tive and potent caspase-6 inhibitor to date. The overall goal of this research project is move one step beyond that success, identifying new exosites in caspases that engage just a subset of caspases substrates will allow us to develop an entirely new class of potential drugs: substrate- selective caspase-directed inhibitors.

PI_NAMEs: HARDY, JEANNE ANN (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Allosteric Site;Alzheimer's Disease;Apoptosis;Apoptotic;Area;Binding;Biology;Cancerous;CASP6 gene;CASP9 gene;Caspase;Cell Death;Cells;Clinical;Development;Disease;Drug Targeting;Family;Goals;Human;inhibitor;interest;Malignant Neoplasms;Marketing;Molecular Conformation;Myocardial Infarction;nanobodies;Nerve Degeneration;neurofibrillary tangle formation;novel;PARK7 gene;Parkinson Disease;Pharmaceutical Preparations;Pharmacologic Substance;Phosphorylation;Play;prevent;Protein Isoforms;Regulation;Reporting;Research;Research Project Grants;Role;Stroke;success;tau Proteins;tau-1;Work;Zinc

PROJECT_TITLE: Discovering and Exploiting Caspase Regulatory, Allosteric and Exosites


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Despite the importance of sleep for health and the prevalence of sleep disorders, the regulation of sleep remains poorly understood. We will use zebrafish to identify genetic and neuronal mechanisms that mediate homeostatic, circadian and light-dependent regulation of sleep, and to identify genes and mechanisms that underlie human sleep disorders. These studies will likely identify novel targets that may eventually lead to new therapies for sleep disorders.

PI_NAMEs: PROBER, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Animals;Behavior;Behavioral Assay;Brain;Candidate Disease Gene;candidate validation;Cells;circadian;circadian regulation;Circadian Rhythms;Complement;Coupled;Cues;Darkness;Economic Burden;Genes;Genetic;genome wide association study;genome-wide analysis;Health;Homeostasis;Human;Hypothalamic structure;Light;Mediating;Melatonin;Melatonin Receptors;Mental disorders;Monitor;Morbidity - disease rate;Mus;mutant;neuronal circuitry;Neurons;Neuropeptides;novel;novel strategies;novel therapeutics;optogenetics;Pathway interactions;Phenotype;poor sleep;Prevalence;Process;programs;Research;Resolution;Rodent Model;Sleep;Sleep Disorders;Sleep Disorders Therapy;sleep health;sleep regulation;Testing;Time;Wakefulness;Zebrafish

PROJECT_TITLE: Genetic and Neuronal Mechanisms that Regulate Zebrafish Sleep


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: How healthcare organizations adapt in response to disruptive change has critical implications for patients. VA recently underwent two unprecedented disruptive changes that fundamentally altered the way in which care is delivered to Veterans. First, expanded community care access under the MISSION Act was implemented in June 2019, representing the biggest policy change in VA care delivery since the "Kizer revolution.” While VA healthcare systems were in the early phases of adapting to MISSION, the COVID-19 pandemic spread rapidly across the world, resulting in a sudden and prolonged ramp-down of elective outpatient care across the entire healthcare system. Our proposed research will leverage this rare combination of events to provide important insights into how large, complex health systems such as VA adapt to manage the health of a population in the face of disruptive forces, the relationship between these adaptation approaches and environmental and organizational characteristics, and their impact on specialty care access and the Veteran experience.

PI_NAMEs: ADAMS, MEGAN ADKINS (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Ambulatory Care;care coordination;care delivery;Caring;Case Study;Characteristics;Cirrhosis;Community Healthcare;comorbidity;Complex;COVID-19;COVID-19 pandemic;economic impact;Enrollment;environmental change;Event;experience;Face;financial incentive;Future;Geography;Goals;Grant;Health;health care service organization;health management;Health Services Accessibility;Health system;Healthcare Systems;improved;Individual;innovation;insight;Interview;Knowledge;Leadership;Measurable;Measures;medical specialties;Methodological Studies;Methodology;Methods;Modernization;Natural experiment;Nephrology;Outcome;Patients;Performance;Phase;Policies;Policy Making;Population;post-COVID-19;Process;Ramp;Recommendation;Recovery;Research;Resources;response;Sampling;Services;Site;Specialist;Structure;System;Telephone;Time;time use;Variant;Veterans;virtual healthcare

PROJECT_TITLE: Understanding the Effects of the MISSION Act on VA's Specialty Care Referral Networks

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We will develop and validate a method to measure brain perfusion in real-time prior to, during, or immediately after an intra-arterial interventional procedure is performed for acute stroke patients in order to make the procedure safer and more effective.

PI_NAMEs: TAGUCHI, KATSUYUKI  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;acute stroke;Agreement;Angiography;arm;Arteries;Blood flow;blood-brain barrier permeabilization;Brain;Brain region;Cerebral Angiography;cerebral artery;Cerebral Infarction;Cerebrum;Coagulation Process;Collateral Circulation;Compensation;Computers;Data;Death Rate;digital;Distal;Foundations;functional outcomes;Growth;Head;Hemorrhage;Hour;improved;indexing;Infarction;interest;Intervention;Ischemia;Ischemic Stroke;Lesion;Letters;Liver neoplasms;Long term disability;Magnetic Resonance;manufacture;Measures;Mechanics;Medical;Methods;Motion;novel;Oncology;Outcome;Patient Admission;Patient Selection;Patients;Perfusion;perfusion imaging;Perfusion Weighted MRI;Procedures;radiologist;Reperfusion Therapy;Retrieval;Risk;Risk-Benefit Assessment;risk/benefit ratio;Roentgen Rays;Rotation;Safety;Scheme;simulation;standard of care;Stroke;stroke intervention;stroke outcome;stroke patient;success;System;Techniques;Testing;Thrombectomy;thrombolysis;Thrombus;Time;Tissue Viability;Tissues;United States;vascular bed;Veins;Work;X-Ray Computed Tomography

PROJECT_TITLE: Assessing brain perfusion using IPEN during intra-arterial stroke intervention

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Social accountability interventions are designed to improve the performance of service providers via public monitoring and the use of feedback mechanisms to address deficiencies in service delivery, but little is known about their true impact on contraceptive use, especially in the context of Universal Health Coverage. This study aims to implement and evaluate two social accountability interventions: the community score card and the citizen report card. A three-armed cluster randomized controlled trial will assess the impact of each of these interventions on contraceptive use over a one-year follow-up period; implementation science research, including in-depth interviews with intervention facilitators and healthcare providers, will be used to assess the acceptability, replicability, and sustainability of social accountability interventions.

PI_NAMEs: TUMLINSON, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Abbreviations;Absenteeism;Accountability;Address;Age;Area;arm;Award;Behavior;care providers;Childbirth;Client;Collaborations;Communities;community empowerment;community engagement;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Country;County;Cross-Sectional Studies;Data;Effectiveness;evidence base;experience;experimental study;Family Planning;Feedback;Fees;Focus Groups;follow-up;Funding;Goals;Health;Health care facility;Health Personnel;Healthcare Systems;implementation barriers;implementation evaluation;implementation science;implementation strategy;improved;Individual;Infant Mortality;interest;Intervention;Interview;Job Satisfaction;Kenya;Knowledge;low income country;Maternal Mortality;Measures;member;Methods;Modeling;Modernization;Monitor;National Institute of Child Health and Human Development;Newborn Infant;Nulliparity;Outcome;Pathway interactions;Patient Rights;payment;Perception;Performance;post intervention;Pregnancy;Pregnancy Rate;Prevalence;Provider;Public Facilities;Public Health;Public Sector;Quality of Care;Randomized;Randomized, Controlled Trials;reinforced behavior;Reporting;reproductive;Research;Research Design;Research Project Grants;Resource-limited setting;Resources;Sampling;scale up;service delivery;service providers;service utilization;Site;Social Accountability;Supervision;Surveys;therapy design;three-arm study;Time;unintended pregnancy;Unmarried;uptake;Wait Time;Woman;Work

PROJECT_TITLE: Randomized Controlled Trial to Address Unintended Pregnancy Rates in Low Resource Settings

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The overall objective of the proposed research is to prospectively investigate the effects of two weight-maintaining diets (low glycemic, moderately CHO-restricted diet vs. fat-restricted diet) on reduction of hepatic lipid content, improvement in hepatic insulin sensitivity, and changes in the plasma metabolome in adolescents with NAFLD. We propose a 6 month, scientifically rigorous, RCT using a family-based design with two phases: a 12-week controlled feeding phase followed by a 12-week free-living phase. As such, results from this trial stand to address three key gaps in knowledge: 1) the role of diet composition in the depleting hepatic lipid content in pediatric NAFLD in the absence of weight loss; 2) the role of diet composition on hepatic insulin sensitivity and whether loss of hepatic lipid is associated with improvement in hepatic insulin sensitivity in pediatric NAFLD, and 3) the changes in metabolic pathways linked to diet-induced depletion of hepatic lipid using high resolution, untargeted metabolomics in pediatric NAFLD.

PI_NAMEs: GOSS, AMY MISKIMON (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adolescent;Adult;age group;amino acid metabolism;Biological Process;Body Weight decreased;Branched-Chain Amino Acids;Calories;Child;Childhood;Cirrhosis;clinical practice;Data;design;Developed Countries;Development;Diet;dietary approach;dietary guidelines;Dietary Intervention;Dietary Practices;dietary restriction;Disease;Disease Progression;Early Intervention;Effectiveness;energy balance;evidence based guidelines;Family;Fat-Restricted Diet;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;feeding;Fibrosis;Food;Glucose Clamp;Glucose Intolerance;Hepatic;high risk;Hyperinsulinism;improved;indexing;Infiltration;Insulin Resistance;insulin sensitivity;Intervention;Knowledge;Life Style;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;Liver Failure;liver transplantation;Macronutrients Nutrition;Magnetic Resonance Imaging;Measures;Metabolic Pathway;metabolome;metabolomics;Methods;Molecular;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;obesity in children;oxidation;Participant;Pathogenesis;Patients;pediatric non-alcoholic fatty liver disease;Peripheral;Pharmacologic Substance;Pharmacotherapy;Phase;Phospholipid Metabolism;Physiological;Pilot Projects;Plasma;Population;Prevalence;prevent;Prevention;prospective;randomized, clinical trials;Recommendation;Reporting;Research;Resolution;response;Role;Sampling;Satiation;Spectrum Analysis;Steatohepatitis;tool;Translations;treatment guidelines;Weight

PROJECT_TITLE: Moderately CHO-restricted diet as treatment targeting improvement in hepatic lipid and insulin sensitivity in adolescents with NAFLD

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Research training is integral to the future of biomedical advancement and the needs of academic centers to provide an environment that integrates the vision of research to deepen our understanding of biology, stimulate interdisciplinary research teams, and reshape clinical research that in turn accelerates medical discovery and improves health. The present proposal will train medical doctors (MDs) and scientists (PhDs) to study the origins of disorders of glucose metabolism in children (illnesses such as obesity, pre-diabetes, diabetes) using basic or clinical science investigation and applying these to accelerate medical discoveries to improve children's health, prevent development and/or ameliorate severity of metabolic diseases. This approach will undoubtedly improve the health of the US population.

PI_NAMEs: OLSON, DAVID P (contact);PADMANABHAN, VASANTHA ;VAZQUEZ, DELIA M

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Development;Metabolic Diseases

PROJECT_TITLE: Developmental Origins of Metabolic Disorders


ORG_CITY: SYRACUSE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: In this project, we will study molecular mechanisms that allow cells to change their shape in order to seek out and destroy pathogens and to take up nutrients and other materials from the extracellular environment. We will specifically investigate the roles of myosins, molecular motor proteins that move along actin filaments, in cell shape changes. In the long term, this work will help us better understand how myosin activity contributes to cell motility, immune response, cell growth, and differentiation.

PI_NAMEs: KRENDEL, MIRA  (contact);SIROTKIN, VLADIMIR A

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adhesions;Affect;Automobile Driving;Binding;Biological Models;Biological Process;cell growth;Cell membrane;Cell model;cell motility;Cell Shape;Cells;Complex;Cytoskeleton;Data;Endocytic Vesicle;Endocytosis;Environment;Eukaryota;Experimental Models;experimental study;extracellular;Filament;Fission Yeast;Gene Modified;Generations;Immune response;Invaded;Knockout Mice;Macrophage;Mammalian Cell;Measures;Mediating;Membrane;Microfilaments;migration;Modeling;Molecular;Molecular Motors;monomer;Motor;Motor Activity;Mus;mutant;Mutation;Myosin ATPase;Myosin Type I;Nonmuscle Myosin Type IIA;Nutrient;pathogen;Phagocytes;Phagocytosis;Physiological;Play;Plus End of the Actin Filament;polymerization;Polymers;pressure;protein crosslink;Proteins;recruit;Regulation;Regulation of Cell Shape;Resistance;Role;Shapes;Site;Structure;System;Tail;Techniques;Testing;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Class I myosins regulate protrusive forces at the actin-membrane interface

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Genetics;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Wound Healing and Care

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life threatening, immune-mediated and largely drug-induced diseases that have high acute morbidity and mortality and poorly defined long-term outcomes without defined evidence-based treatment strategies. We will perform the first double-blinded randomized controlled multicenter study to determine the benefit of cyclosporine or etanercept over supportive care for the treatment of SJS/TEN. We will fill critical research gaps necessary to prevent SJS/TEN and improve patient outcomes by: 1) Establishing the most effective management; 2) Identifying genetic and other biological markers to aid prevention, early diagnosis, risk stratification and treatment; and 3) Elucidating cellular and molecular signatures and specific antigens that define the mechanistic basis and population risk of SJS/TEN.

PI_NAMEs: PHILLIPS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Adult;adverse drug reaction;Adverse effects;Affect;African;African American population;Age;Alleles;American;antagonist;Antigens;Automobile Driving;biobank;Biological;Biological Assay;Biological Markers;Blinded;Blood;Body Surface Area;Bulla;Carbamazepine;CD8-Positive T-Lymphocytes;Cell Surface Proteins;Cells;Clinical;clinical care;cost effective;Country;Cryopreservation;Cyclosporine;cytokine;design;Diagnosis;Disease;Disease Progression;DNA;Double-Blind Method;Drug Design;Drug Exposure;Drug Kinetics;Drug Tolerance;Early Diagnosis;effective therapy;efficacious treatment;Emergency Situation;Enrollment;Epitopes;Etanercept;Ethnic Origin;European;evidence base;Evidence based treatment;Exposure to;follow-up;Future;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Screening;Genetic Transcription;genome-wide;Geography;Half-Life;high risk;Hispanic;Hispanic Americans;Histocompatibility Antigens Class I;HLA Antigens;human leukocyte antigen testing;Immune;Immune response;Immunologics;immunomodulatory therapies;immunopathology;implementation cost;improved;In Vitro;infection rate;Intensive Care;Intervention;Intravenous Immunoglobulins;Knowledge;Left;Length of Stay;Level of Evidence;Life;Liquid substance;Low Prevalence;Measures;Mediating;Molecular Profiling;Morbidity - disease rate;mortality;Multicenter Studies;multiple omics;novel;Observational Study;optimal treatments;Outcome;Patient-Focused Outcomes;Patients;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;phase 3 study;Phenotype;Plasma;Population;Population Control;predictive marker;Predictive Value;prevent;Prevention;Prevention strategy;Preventive;primary outcome;Prognosis;protein expression;Race;Randomized;randomized controlled design;Randomized, Controlled Trials;re-epithelialization;Reporter;repository;Research;Resolution;Risk;Risk Factors;risk prediction;risk stratification;RNA;Role;Sampling;screening;screening program;secondary outcome;Severities;Severity of illness;sex;Site;Skin;southeast Asian;Southeastern Asia;Specificity;standard of care;Stevens-Johnson Syndrome;Subgroup;Supportive care;Syndrome;T-Cell Antigen Receptor Specificity;T-Cell Receptor;targeted treatment;Testing;Therapeutic;Time;Tissues;Toxic Epidermal Necrolysis;transcriptome;transcriptomics;treatment arm;treatment effect;Treatment outcome;treatment response;treatment strategy;Tumor Necrosis Factor Receptor;United States;Urine;Variant

PROJECT_TITLE: NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Our project entitled `Modelling Longitudinal Reading Comprehension in Adolescence: Protective and Risk Factors' brings together multidisciplinary researchers to advance our understanding of reading comprehension in adolescents and how reading comprehension changes over time. Our overarching goals are to determine the structure of reading comprehension in 11th grade, clarify key predictors of reading comprehension within and across adolescence, and to identify protective and risk factors for good and poor reading comprehension.

PI_NAMEs: BRIDGES, MINDY S (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: academic standard;Achievement;Address;Adolescence;Adolescent;Adopted;Affect;base;bilingualism;Child;Cognitive;Common Core;Complex;Educational Curriculum;elementary school;eleventh grade;English Language;Ethnic Origin;evidence base;executive function;Female;Foundations;Goals;high risk;high school;High School Student;Home;improved;Influentials;Intervention;junior high school;Knowledge;Language;Language Arts;Linguistics;listening comprehension;Longitudinal Studies;male;Modeling;Motivation;multidisciplinary;Nature;ninth grade;non-verbal;Nursery Schools;Participant;predictive modeling;protective factors;psychologic;Race;Reader;Reading;reading ability;reading comprehension;reading difficulties;Recording of previous events;Research;Research Personnel;Risk;Risk Factors;Sampling;school environment;Science;sex;sixth grade;Source;Spanish/English;Structure;Students;Testing;Text;Theoretical model;theories;Time;Work

PROJECT_TITLE: Modeling Longitudinal Reading Comprehension in Adolescence: Protective and Risk Factors


NIH_SPENDING_CATS: Genetics

PHR: Non-coding RNA forms the cell’s machinery for protein synthesis and creates regulatory switches that turn genes on and off in response to stress or infection. To function properly, these RNAs must fold into particular three-dimensional shapes soon after they are synthesized. This research will use tools for imaging single molecules and for visualizing RNA structure within the cell to predict how RNA molecules promote healthy growth and why they sometimes cause disease.

PI_NAMEs: WOODSON, SARAH A. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3-Dimensional;Address;Anabolism;Bacteria;Base Pairing;Binding Proteins;biological adaptation to stress;Biological Assay;Biological Models;Cells;Coupled;Development;Disease;Fluorescence;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Imaging Device;Infection;Link;Malignant Neoplasms;Mass Spectrum Analysis;Messenger RNA;Molecular Chaperones;mRNA Expression;Mutation;Nerve Degeneration;Pathway interactions;Post-Transcriptional Regulation;programs;Protein Biosynthesis;protein complex;Protein Splicing;Proteins;Recycling;Regulation;Reporter;Research;response;Ribosomes;RNA;RNA Folding;Shapes;single molecule;Small RNA;Stress;Structure;Untranslated RNA;Visualization

PROJECT_TITLE: Assembly Mechanisms of RNA-Protein Complexes for Genetic Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The Research Training Program for Pediatric Subspecialty Fellows at UPMC Children's Hospital of Pittsburgh supports the training of physician-scientists who seek to improve child health through research. The broad public health significance of this program will be realized through the academic and scholarly accomplishments of the trainees, with connections to both the direct treatment of patients in the clinical setting and the discovery of disease mechanisms and new therapeutic agents.

PI_NAMEs: DERMODY, TERENCE S. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Chronic liver disease is a major global health problem that affects over 1 billion people worldwide and contributes up to 2 million deaths annually. Nearly all the deaths result from progression of liver fibrosis. In this proposal, we aim to characterize the cellular and molecular mechanism(s) underlying liver sinusoidal endothelial cell capillarization, which is a common event in liver fibrosis.

PI_NAMEs: VILARINHO, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Affect;Ascites;Basement membrane;Blood flow;Blood Vessels;Capillarity;Cause of Death;CD34 gene;cell dedifferentiation;Cell Separation;Cells;Cessation of life;chronic liver disease;chronic liver injury;Cirrhosis;Clinical;clinically significant;common treatment;Complex;Critical Pathways;Cues;curative treatments;Cytoplasm;Data;end stage liver disease;Endothelial Cells;Esophagus;Etiology;Event;Extracellular Matrix;Foundations;Functional disorder;Future;GATA4 gene;Genetic;Genotype;global health;Goals;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatology;Homeostasis;Human;Individual;insight;Investigation;Knowledge;Lead;lens;Liver;Liver Cirrhosis;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver injury;liver transplantation;loss of function;loss of function mutation;Loss of Heterozygosity;Lysosomes;mechanical signal;Medical;microtubule-associated protein 1B;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;mouse model;Mus;mutant mouse model;Names;new therapeutic target;novel;novel diagnostics;novel therapeutics;Organ Donor;Pathogenesis;Pathology;Patients;Persons;Phenotype;Physiological;Piezo 1 ion channel;Portal Hypertension;pressure;prevent;Process;prognostic;Publishing;Rare Diseases;Reporting;Research;Role;shear stress;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;Sorting;Specific qualifier value;Therapeutic;Time;tool;transcription factor;Venous;Work

PROJECT_TITLE: Liver Pathobiology: insights through the lens of rare diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(03)]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: Whereas some tumor-infiltrating T cells have the ability to directly recognize and kill cancer cells, the majority of infiltrating T cells are not reactive to tumor-expressed antigens, implying that these T cells may have unique functions that are not fully appreciated. Here, we demonstrate that "memory-phenotype" CD8+ T cells reactive to non-mutated endogenous antigens infiltrate mouse prostate tumors and express high levels of the inhibitory receptor PD-1, suggesting a critical role for these cells in the tumor context. This work will define the functional role of memory-phenotype CD8+ T cells in modulating tumor development and anti-tumor immunity, and define the molecular and cellular blueprints of how these cells are generated in the body, thereby revealing new ways to identify and manipulate these cells in human cancer patients.

PI_NAMEs: SAVAGE, PETER AIDAN (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adult;anti-PD-1;Antigens;Area;Atypical lymphocyte;Autoantigens;Automobile Driving;Biological Assay;Biology;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cells;comparative;Cues;Data;Dendritic Cells;Development;Exhibits;experience;experimental study;FOXP3 gene;Gene Expression Profiling;Goals;Human;human disease;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunologics;Individual;Infiltration;Inflammatory;insight;interest;Interferon Type II;Knowledge;Laboratories;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Marker Discovery;Melanoma;Memory;Minor;Molecular;mouse model;Mus;Mutate;Nature;novel;novel marker;Oncogenes;pathogen;Peptides;Phase;Phenotype;Play;Population;Process;Production;programmed cell death protein 1;Proliferating;Property;Prostatic Neoplasms;receptor;Recurrence;Regulatory T-Lymphocyte;Reproducibility;Research;response;Role;Signal Transduction;Specificity;success;T cell infiltration;T memory cell;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;thymocyte;Thymus Gland;transcription factor;transgenic adenocarcinoma of mouse prostate;Transplantation;tumor;Tumor Antigens;Tumor Immunity;Tumor stage;Tumor-Infiltrating Lymphocytes;Up-Regulation;Work

PROJECT_TITLE: Differentiation and function of intratumoral memory-phenotype CD8+ T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative Hepatitis B virus (HBV) chronically infects more than 240 million people worldwide. The overall objective of this application is to determine molecular mechanism of cell surface receptors promoting HBV infection. We expect to identify novel antiviral targets and to develop a new HBV mouse model towards searching a cure for chronic hepatitis B.

PI_NAMEs: LUO, GUANGXIANG GEORGE (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;Affect;American;anti-hepatitis B;Anti-viral Agents;Anti-viral Therapy;Apolipoprotein E;apolipoprotein E receptor 2;apolipoprotein E-3;Binding;Biological Assay;Blocking Antibodies;Cell Culture System;Cell Culture Techniques;Cell Line;Cell Surface Receptors;Cell-Matrix Junction;Cessation of life;Chronic;Chronic Hepatitis;Chronic Hepatitis B;Circular DNA;Cirrhosis;Core Protein;CRISPR/Cas technology;Cross Infection;Crossbreeding;Development;DNA biosynthesis;DNA Maintenance;Drug Targeting;Enzymes;experimental study;Gene Expression;Genes;global health;Glypican;Goals;GPC3 gene;HBV Animal Model;Hela Cells;Heparan Sulfate Biosynthesis;Heparan Sulfate Proteoglycan;Hepatitis B;Hepatitis B Infection;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C Antiviral;Hepatocyte;Human;humanized mouse;In Vitro;in vivo;Infection;inhibitor;Interferons;Knock-in Mouse;Knock-out;knockout gene;Knockout Mice;Knowledge;Liver diseases;Low Density Lipoprotein Receptor;Mediating;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Na(+)-taurocholate-cotransporting peptide;novel;novel therapeutics;nucleoside analog;overexpression;Patients;Persons;Pharmaceutical Preparations;Physiological;Play;prevent;Primary carcinoma of the liver cells;Production;prophylactic;Proprotein Convertases;Protein Family;proteoglycan core protein;Public Health;receptor;Risk;Role;Small Interfering RNA;Subtilisins;Surface;Therapeutic;Transgenic Mice;Transgenic Organisms;Viral;Viral hepatitis;Virus Diseases;virus envelope;virus identification;Virus Receptors;Virus Replication;VLDL receptor;World Health Organization

PROJECT_TITLE: Cell surface receptors promoting hepatitis B virus infection

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]