ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Back Pain;Bioengineering;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE A machine learning ‘global’ brain aging biomarker based on structural Magnetic Resonance Imaging (MRI), used by our lab to show that chronic musculoskeletal pain (MSK) appears to accelerate brain aging compared to healthy control individuals, is unable to distinguish among different MSK conditions. Based on previous MRI data suggesting that different MSK conditions exhibit distinct signatures of brain atrophy, we propose the use of spatially distributed brain aging biomarkers based on deep learning methods as potential measures that would inform biomarkers of MSK diagnosis and prediction, as well as of prognosis of pain-related disability. This project will identify novel biomarkers of chronic pain and shed light into the neurobiological mechanisms of pain and aging; while also providing the principal investigator with expertise in Artificial Intelligence and machine learning, and skills and knowledge about the neurobiology of pain and aging, propelling his academic career towards independence.

PI_NAMEs: VALDES HERNANDEZ, PEDRO ANTONIO (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acceleration;Adult;Affective;Age;age difference;age effect;age related;age related biomarkers;Aging;aging biomarker;aging brain;aging mechanism;Area;Artificial Intelligence;artificial intelligence method;Attention;Back Pain;biobank;Biological Markers;Brain;Brain imaging;brain morphology;career;cerebral atrophy;chronic back pain;chronic musculoskeletal pain;chronic pain;Chronology;Classification;Clinical;Cognitive;computing resources;convolutional neural network;Data;Data Set;deep learning;design;Development;Diagnosis;diagnostic biomarker;Dimensions;disability;Disease;Endowment;Exhibits;experience;flexibility;Florida;follow-up;functional decline;Functional Magnetic Resonance Imaging;Future;Goals;Health;High Performance Computing;High Prevalence;Image;improved;Individual;Infrastructure;innovation;insight;Institution;Knowledge;Light;Linear Regressions;Machine Learning;machine learning model;Magnetic Resonance Imaging;Maps;Measures;Medial;Memory;Mentorship;Methodology;Modeling;morphological criteria;Musculoskeletal;Musculoskeletal Pain;Neck Pain;neural;neural network architecture;Neural Network Simulation;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;novel;novel marker;Nucleus Accumbens;older adult;osteoarthritis pain;Pain;pain chronification;pain inhibition;pain perception;pain sensitivity;pain-related disability;Participant;Pathologic;Pathology;Pattern;Persons;Prefrontal Cortex;Prevalence;Principal Investigator;Prognosis;prognostic assays;prognostic value;prognostication;psychosocial;Questionnaires;Recovery;Reporting;Rest;Risk;Sensory;Severities;Shoulder Pain;Signal Transduction;skills;specific biomarkers;Specific qualifier value;Specificity;Subgroup;Techniques;Testing;Thick;Training;United States;Universities;Vision;young adult

PROJECT_TITLE: Machine learning-based brain aging morphological signatures of chronic musculoskeletal pain

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Acute kidney injury (AKI), the sudden loss of kidney function manifesting as the accumulation of fluid and metabolic waste and impaired electrolyte and acid-base regulation, is a common, costly, and potentially life- threatening condition for which there is no effective treatment. AKI causes cell death in the kidney by compromising a number of intracellular processes, including protein regulation. This project will, therefore, investigate the relationship between disruption of protein regulation and AKI with the goal of identifying key molecules that could be targeted by novel AKI pharmaceuticals.

PI_NAMEs: PORTER, AIDAN  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Acids;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Animal Model;Animals;Apoptosis;Apoptotic;Applications Grants;arm;ATF6 gene;Award;base;biological adaptation to stress;Biological Assay;career;Caspase;Cell Culture Techniques;Cell Death;cell injury;Cell Survival;Cells;Cessation of life;Cisplatin;Clinic;clinically relevant;Competence;Confounding Factors (Epidemiology);cost;Creatinine;Cytoprotection;cytotoxic;Data;Defect;deprivation;Development;Dialysis procedure;Drug Modulation;effective therapy;Electrolytes;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Enzymes;Epithelial Cells;Event;Exhibits;experience;experimental study;Exposure to;Female;Functional disorder;Funding;Genes;Germ Cells;Glucose;glucose-regulated protein 170;Goals;Healthcare;Heat shock proteins;Heterozygote;Homeostasis;Hospitalization;Image;Impairment;In Situ Nick-End Labeling;in vivo;in vivo Model;Individual;inhibitor;Injury;Injury to Kidney;Integral Membrane Protein;Intensive Care;Intervention;Investigation;Ischemia;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Knockout Mice;LCN2 gene;Life;Link;Liquid substance;male;Mammals;Measures;meetings;Mentors;Mentorship;Metabolic;Methods;Microscopy;Mitochondria;Modeling;Molecular Chaperones;Morbidity - disease rate;Morphology;mortality;mRNA Expression;mRNA Translation;Mus;Names;Nephrons;nephrotoxicity;novel;Organelles;oxidative damage;Oxygen;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiology;post gamma-globulins;pre-clinical;Predisposition;preservation;prevent;Process;protective pathway;Protein Biosynthesis;protein expression;protein folding;Proteins;proteostasis;Proximal Kidney Tubules;Publishing;receptor;Recording of previous events;Records;Regulation;renal epithelium;Renal function;Renal tubule structure;Reperfusion Injury;Research;Research Personnel;Resources;response;Role;Scientist;sensor;sex;Signal Transduction;skills;Small Interfering RNA;Sorting;Stress;stressor;Techniques;Testing;Therapeutic;Time;Tissues;tool;Toxin;Training;transcription factor;transcriptomics;Translation Process;treatment response;Tubular formation;United States National Institutes of Health;Universities;wasting;Writing

PROJECT_TITLE: Endoplasmic Reticulum Protein Homeostasis in Renal Physiology and Acute Kidney Injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Non-alcoholic fatty liver disease (NAFLD) affects ~30% of the global adult population and is associated with morbidity and mortality from hepatic and extra-hepatic complications, causing a major health burden for our society. Hepatic lipid droplets (LDs) have emerged as important players in NAFLD, yet their impact on its pathogenesis and progression is not fully understood. By studying common genetic coding variants in two LD proteins (PNPLA3-I148M and PLIN2-Pro251), this proposal aims to elucidate the role of LDs in NAFLD, leading to a better understanding of this disease and providing new therapeutic targets.

PI_NAMEs: SCORLETTI, ELEONORA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Adopted;Adult;Advisory Committees;Affect;Arachidonic Acids;Attention;biobank;Biochemical;Biogenesis;Bioinformatics;Biological Markers;Biological Models;Biology;Blood;Cardiovascular Diseases;Cell Death;Cells;Clinical;comorbidity;Cytosol;design;dietary;Disease;Disease Progression;Doctor of Philosophy;eicosanoid metabolism;Eicosanoid Production;Eicosanoids;extracellular;Extrahepatic;fasting glucose;fatty acid metabolism;fatty acid oxidation;Flow Cytometry;Food;Future;Genes;Genetic Code;genetic variant;Genome;Genomic medicine;Genotype;Glycosylated hemoglobin A;Health;health data;Heart;Hepatic;Hepatocyte;High Density Lipoproteins;Human;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;Insulin;Iron;Learning;lipid mediator;lipidomics;Lipids;Literature;Liver;Liver diseases;liver inflammation;liver transplantation;Mass Spectrum Analysis;Measures;Medical History;Medicine;Membrane;Mentors;Metabolic;Metabolism;Methods;monolayer;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Oxidative Stress;Participant;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Phase;phenomics;Phenotype;Phospholipids;Physical activity;Physical Examination;Physiology;PLA2G6 gene;Plasma;pluripotent stem cell differentiation;Polyunsaturated Fatty Acids;Population;precision medicine;prevent;primary endpoint;Principal Investigator;Production;Proteins;Questionnaires;recruit;Research;Risk;Risk Factors;Role;Science;Severities;simple steatosis;skills;Societies;Specialist;Sphingolipids;Systems Biology;Techniques;tool;trafficking;Training;Triglycerides;United States National Institutes of Health;Urine;Variant;Very low density lipoprotein;Vesicle

PROJECT_TITLE: The role of lipid droplet proteins in eicosanoid production and non-alcoholic fatty liver disease

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Patients with HOS frequently receive delayed treatment and have nearly 3-fold greater risk of ARF and death than patients with community-onset sepsis yet remain an understudied population. A current absence of data characterizing clinical presentation, ARF risk, and treatment benefit in HOS presents a critical barrier to designing interventions that improve treatment timing and prevent ARF for the most vulnerable patients. This proposal aims to identify latent clinical HOS phenotypes, develop a model predicting progression to ARF in HOS, and estimate heterogeneity in the effect of antimicrobial delays among patients with hospital-onset sepsis.

PI_NAMEs: GINESTRA, JENNIFER CLAIRE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accounting;Acute respiratory failure;Address;Algorithms;antimicrobial;Antimicrobial Effect;Award;Calibration;Cannulas;career;career development;Caring;Cessation of life;Clinical;clinical phenotype;cohort;Communities;comorbidity;comparative effectiveness study;Consensus;Data;Data Set;Databases;Deterioration;Development;Discrimination;Drug resistance;effectiveness study;Electronic Health Record;Foundations;Functional disorder;Funding;Future;Goals;Health system;Heterogeneity;high risk;Hospital Administration;Hospitalization;Hospitals;Hour;improved;improved outcome;indexing;Individual;individual patient;individualized medicine;Infection;innovation;Institution;Intensive Care;interest;Intervention;Intubation;Knowledge;Lead;Leadership;Logistic Regressions;Machine Learning;machine learning prediction;Measures;Mechanical ventilation;Medical;meetings;Mentorship;Methodology;Methods;Modeling;Nose;novel;Organ;Organ failure;Outcome;Patient Admission;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized approach;Phenotype;Physiological;Population;predictive modeling;prevent;Probability;Prognosis;programs;progression risk;Reproducibility;Research;Research Training;respiratory;Retrospective cohort;Risk;risk prediction model;risk stratification;Sepsis;Sepsis Syndrome;septic patients;Severity of illness;skills;Subgroup;Testing;therapy design;therapy development;Time;tool;Training;Treatment Effectiveness;Treatment Failure;treatment guidelines;treatment strategy;Work

PROJECT_TITLE: Treatment implications of heterogeneity in acute respiratory failure risk among patients with hospital-onset sepsis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Alcoholic liver disease or alcohol-associated/related liver disease (ALD) is caused by chronic alcohol abuse and is a serious health concern worldwide. Production of extracellular vesicles (EVs) in ALD is significantly increased and contributes to the pathogenesis of ALD significantly. However, the mechanism of this enhanced production is not known. We are proposing that chronic use of alcohol inhibits hepatic autophagy function, which in turn activates a chain reaction mediated by several new molecules, which lead to increased EVs production. This hypothesis is supported by preliminary studies and is conceptually novel. Completion of this study will also provide a novel way to mitigate the liver injury in ALD.

PI_NAMEs: YIN, XIAO-MING  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Acute;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol response;Alcoholic Liver Diseases;Alcohols;Autophagocytosis;Autophagosome;Body Fluids;Cell Physiology;Cells;Chronic;chronic alcohol ingestion;Cirrhosis;Clinical Management;Diagnosis;diagnostic development;differential expression;effective therapy;Extracellular Space;extracellular vesicles;feeding;Fibrosis;Future;Gene Modified;Generations;Goals;Health;Hepatic;Hepatocyte;Homologous Gene;Human;improved;Inflammation;Inflammation Process;inhibition of autophagy;innovation;Knowledge;Link;Lipids;Liver;Liver diseases;liver injury;Lysosomes;Malignant Neoplasms;Mediating;MicroRNAs;Molecular;Molecular Profiling;Molecular Target;mouse model;Mus;novel;Nucleic Acids;Pathogenesis;Pathologic;Pathology;Pathway interactions;Physiological;problem drinker;Process;Production;protective effect;Proteins;Reaction;Regulatory Pathway;response;Signal Transduction;Source;therapeutic development;Up-Regulation;uptake;vesicular release

PROJECT_TITLE: A molecular mechanism of extracellular vesicle production by alcoholic livers andthe functional impact

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Project Narrative The main goal of this proposal is to understand how the brain learns from experience to provide reliable information about the environment, which is essential to produce adequate behavioral responses. Proposed experiments will provide basic science discoveries necessary to better understand and treat pathologies that disrupt perceptual maturation, such as autism and Fragile X syndrome.

PI_NAMEs: LEMPEL, AUGUSTO ABEL (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Anatomy;Animals;Architecture;Area;area striata;authority;autism spectrum disorder;Basic Science;Behavior;Behavioral;behavioral response;Biological Models;Brain;calmodulin-dependent protein kinase II;Cells;Chronic;Cognition;Collaborations;Consult;Coupled;Data;design;Development;Discrimination;Electrodes;Enhancers;Environment;excitatory neuron;experience;experimental study;Eye;Feedback;Ferrets;Florida;Fostering;Fragile X Syndrome;Future;Genetic;Goals;Image;Imaging Techniques;improved;Individual;inhibitory neuron;Institution;juvenile animal;Knowledge;Laboratories;Learning;Light;Link;Location;Measures;Mentors;Methodology;Methods;Neurons;Neurosciences;novel;Occupations;Output;Pathology;Perception;Phosphotransferases;Population;Positioning Attribute;prevent;Property;Recurrence;Research;Research Personnel;Resolution;response;Response to stimulus physiology;Role;Secure;Sensory;sensory cortex;Signal Transduction;skills;Source;Stimulus;Structure;Study models;success;Synapses;Synaptic plasticity;Techniques;tenure track;Testing;timeline;tool;Training;transmission process;two-photon;vision development;Visual;Work

PROJECT_TITLE: Experience-driven development of reliable stimulus representations in dynamic cortical networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Contraception/Reproduction;Fibroid Tumors (Uterine);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Uterine fibroids affect up to 80% of women in reproductive age and the economic impact in the United State is estimated to be nearly $34 billion annually. Fibroids account for 50% of the hysterectomies performed in the United States, and in order to develop alternatives to hysterectomy, a major gap in our understanding of how different fibroid mutations lead to disease needs to be investigated. This proposal addresses three goals of NICHD interest, improving reproductive health, health disparities and disease prevention, through studies that will determine the functional role of two most common mutations found in uterine fibroids and discover novel, personalized therapies by using the transcriptomic profile of each fibroid subtype.

PI_NAMEs: PAUL, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Affect;Age;Agonist;antagonist;Apoptosis;assay development;Award;Benign;Biological Assay;black women;cancer cell;candidate selection;career;career development;Cell Cycle;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;design;Development;Disease;disease disparity;disorder prevention;DNA Sequence Alteration;DNA-Directed RNA Polymerase;Doctor of Philosophy;drug candidate;Drug Compounding;Drug Delivery Systems;drug discovery;drug synthesis;Drug Targeting;drug testing;economic impact;effective therapy;Embryonic Development;Enantone;Environment;Enzymes;Ethnic Origin;Etiology;expectation;experience;Faculty;Fertility;Fetal Development;Fibroid Tumor;Foundations;Future;Gene Expression Profile;Genetic;Genetic Transcription;GNRH1 gene;Goals;Growth;Health Care Costs;health disparity;high throughput screening;high-throughput drug screening;Histopathology;HMGA2 gene;HMGA2 Protein;Hormones;Human;Hysterectomy;Impairment;improved;in silico;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;interest;Knowledge;Laboratories;Lead;Learning;Link;Malignant Neoplasms;Mediator;Mentors;metallicity;Methylation;Michigan;Modeling;Morbidity - disease rate;mutant;Mutate;Mutation;Myometrial;myometrium;nanoparticle exposure;National Institute of Child Health and Human Development;novel;novel therapeutics;Oral;Outcome;overexpression;Pathway interactions;Patients;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Pharmacology and Toxicology;Phenotype;Physiological Processes;Placenta;Point Mutation;Population Characteristics;Positioning Attribute;post-doctoral training;Pregnancy;preservation;Process;protein complex;Race;racial disparity;Regulation;reproductive;Reproductive Health;reproductive tract;Research Personnel;Research Project Grants;Risk;Role;screening;Secure;Seminal;senescence;side effect;Smooth Muscle;Specialist;spheroids;stem cell biomarkers;Steroids;System;tenure track;Testing;Therapeutic;therapeutic candidate;Therapeutic Studies;therapeutically effective;Tissue-Specific Gene Expression;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Transfection;treatment strategy;tumor;tumorigenesis;United States;Universities;Uterine Fibroids;Uterine Neoplasms;Uterus;White Women;Woman;women's reproductive health

PROJECT_TITLE: Understanding the functional role of fibroid subtype mutations for drug discovery

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative: Gliomas are the most common primary brain tumors in adults, a subset of which harbor mutations in the metabolic gene isocitrate dehydrogenase 1 (IDH1). My project uses a novel genetically engineered mouse model of mutant IDH1-driven astrocytoma and other models to address how mutant IDH1 inhibitors affect glioma tumor biology, with the goal of leveraging this knowledge to develop new therapies. Collectively, these studies will address clinically relevant questions with direct translational applicability to patients with IDH1-mutant gliomas.

PI_NAMEs: SHI, DIANA  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;alpha ketoglutarate;alternative treatment;Animal Model;Antitumor Response;Astrocytoma;Automobile Driving;Biological Markers;Biological Models;Biology;career;career development;cell transformation;Cells;Clinical;clinically relevant;cohort;Complement;CRISPR screen;Dana-Farber Cancer Institute;Daphne plant;Dependovirus;Detection;dihydroorotate;Dihydroorotate dehydrogenase;Dihydroorotate Dehydrogenase Inhibitor;Dioxygenases;DNA Damage;Doctor of Philosophy;Engineering;Enterobacteria phage P1 Cre recombinase;Environment;Enzyme Inhibition;Epigenetic Process;experimental study;Gene Mutation;Genes;genetic approach;Genetic Transcription;Genetically Engineered Mouse;Glioma;Gliomagenesis;Goals;Growth;Human;Immunocompetent;improved;improved outcome;In Vitro;inhibitor;inhibitor therapy;Injections;insight;instructor;Isocitrate Dehydrogenase;Knowledge;Laboratories;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Mediating;Mediator;medical schools;Mentors;Metabolic;Modeling;Molecular;molecular dynamics;Molecular Profiling;mouse model;Mus;mutant;mutant mouse model;Mutation;neuro-oncology;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Organoids;Oxidoreductase;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Physicians;Predisposition;Preparation;Primary Brain Neoplasms;Production;Progression-Free Survivals;Pyrimidine;Radiation;Radiation Oncologist;radiation response;Radiation Tolerance;Randomized;Reporting;Research;research and development;Research Personnel;response;Scientist;standard of care;stem-like cell;System;Testing;Therapeutic;Time;Training;transcriptomics;Transgenic Mice;treatment strategy;tumor;Tumor Biology;Work

PROJECT_TITLE: Molecular Dynamics of Glioma Formation and DNA Damage Response by Mutant IDH1

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative The content of THC in cannabis is now at unprecedented levels and teenage use is at historic highs. The experiments in this proposal will fill gaps in knowledge regarding the long-term impact of adolescent cannabis use on psychiatric risk by using interdisciplinary molecular and behavioral techniques. This research will provide significant insights about specific transcriptomic and physiological signatures in the cells associated with adolescent exposure to high dose THC and expand understanding of the mechanisms underlying psychopathologies including cannabis use disorder.

PI_NAMEs: FERLAND, JACQUELINE-MARIE  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Affect;Amygdaloid structure;Animals;Astrocytes;Attitude;Behavior;Behavioral;Behavioral Model;behavioral phenotyping;Biochemical;Brain region;Calcium;Cannabis;career;Cell Shape;Cells;Chronic;CNR1 gene;Cognition;Cognitive;cognitive control;Cognitive deficits;Consumption;Data;Decision Making;Development;disorder risk;Dose;Down-Regulation;Drug usage;Exhibits;exogenous cannabinoid;experience;experimental study;Exposure to;Fiber;Fostering;Genes;Genetic;Glutamates;Human;Imprisonment;improved;Impulsivity;in vivo;insight;interdisciplinary approach;Knowledge;Length;Link;Long-Term Effects;maladaptive behavior;marijuana decriminalization;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Marketing;Measures;Mediating;Mental disorders;Mentors;Mentorship;Modeling;Molecular;Morphology;mRNA Expression;negative affect;Neurobiology;Neurons;neuropsychiatry;novel;optimism;Pattern;Pharmaceutical Preparations;Phenotype;Photometry;Physiological;Play;Population;Positioning Attribute;pre-clinical;Process;programs;Psychopathology;Rattus;Recreation;recruit;Research;Research Personnel;response;Rewards;Risk;Role;Self Administration;Signal Transduction;single cell sequencing;skills;social stigma;Stress;stress reactivity;Substance Use Disorder;Synapses;Techniques;Teenagers;Tetrahydrocannabinol;THC exposure;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Up-Regulation;Yasmin

PROJECT_TITLE: Determining the role of tripartite cell populations in THC-Induced behavioral phenotypes

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: AWARDED PROJECT NARRATIVE Although Black Americans are twice as likely to have Alzheimer’s disease than White Americans, little is known about the impact of social and societal determinants of health on neurocognitive integrity of the medial temporal hippocampal memory and prefrontal-executive systems, the primary brain systems impacted in Alzheimer’s disease. The objective of this application is to investigate the impact of interpersonal and institutional/structural racism on neurocognitive integrity of these brain systems in Black adults aged 65 years and older and to examine cardiovascular disease risk as an underlying biological mechanism. Addressing this knowledge gap is critical for developing new health policies and biobehavioral and social interventions for healthy aging.

PI_NAMEs: SCHON, KARIN  (contact)

PROJECT_TERMS: Acculturation;Address;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Award;biobehavior;Biological;Black American;Black race;Brain;brain health;cardiovascular disorder risk;caucasian American;Chronic;Chronic stress;Cognitive;comorbidity;Dementia;Disparity;Education;Exhibits;experience;Functional Magnetic Resonance Imaging;Genetic Risk;Goals;Grant;health determinants;health disparity;health inequalities;health literacy;Health Policy;healthy aging;Hippocampus;human old age (65+);Institution;Knowledge;Medial;Mediating;Memory;Mental Health;multimodal neuroimaging;Nerve Degeneration;Neurocognitive;neuroimaging;Outcome;parent grant;Parents;Proxy;racism;Research;Risk Factors;social;social interventions;social norm;social stigma;Societies;Socioeconomic Status;Statistical Models;stressor;Structural Racism;success;System;Training

PROJECT_TITLE: Perceived racism, cardiovascular disease risk, and neurocognitive aging: Diversity Supplement


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Carcinomas arising from Meibomian glands, the specialized sebaceous glands of the eyelid, exhibit aggressive phenotypes, resulting in worrisome rates of local recurrence and metastasis, which are often refractory to treat- ment, despite sight-threatening surgical resection. The genomic determinants driving these features of malig- nancy in ocular adnexal sebaceous carcinomas remain poorly resolved. Interrogating the upstream regulation and downstream consequences of MYC expression in the initiation and progression of these tumors will provide new information that may facilitate the development of precision therapies for affected patients world-wide.

PI_NAMEs: PETERSON, CORNELIA WARD MARY (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Affect;Automobile Driving;Biology;Carcinoma;cell behavior;Cell Survival;Cells;Clinical;clinical translation;comparative;Complementary DNA;conjunctiva;Data;Death Rate;design;Development;Diagnosis;Disease;Distant Metastasis;Ensure;Environment;Epithelium;Event;Excision;Exhibits;Eye Carcinoma;Eyelid structure;Gene Expression Alteration;gene repair;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Human;Human Papillomavirus;Immunooncology;Immunosuppression;In Vitro;in vivo;Injections;Insulin;intraepithelial;Invaded;loss of function;loss of function mutation;LoxP-flanked allele;Malignant - descriptor;Malignant Neoplasms;Mediating;meibomian gland;Mentors;Mismatch Repair;Modeling;Molecular;Molecular Biology;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic;novel;Ocular Pathology;Oncogenic;Oncology;Operative Surgical Procedures;overexpression;Pathology;Patients;pharmacologic;Phenotype;Precision therapeutics;preclinical evaluation;Process;Proliferating;Proteins;Proto-Oncogenes;RB1 gene;Receptor Protein-Tyrosine Kinases;Recurrence;Refractory;Regulation;Research;Resources;Risk;Role;Scientist;Sebaceous Adenocarcinoma;Sebaceous Glands;Signal Pathway;Signal Transduction;Site;skills;Skin Appendage Carcinoma;skip lesion;Somatomedins;Suppressor Mutations;Tamoxifen;therapeutically effective;Tissues;tool;TP53 gene;Training;Transcription Alteration;transcription factor;transcriptome sequencing;transcriptomics;Translational Research;tumor;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Universities;Veterinary Pathology;Vision;vision science;Work

PROJECT_TITLE: Investigating the Role of MYC in Meibomian Gland Oncogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


ADMINISTERING_IC: HS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Integrated behavioral health (IBH) holds great promise for improving care quality and outcomes for patients with co-occurring mental and physical health conditions by embedding mental health and substance use treatment services into primary care settings. Despite over two decades of effort, however, there still lacks widespread IBH implementation due to insufficient leadership skills to overcome organizational, attitudinal, and financial challenges. This study develops and tests an evidence-based IBH intervention that incorporates leadership concepts to prepare primary care teams to overcome IBH implementation challenges and effectively lead IBH initiatives.

PI_NAMEs: NGUYEN, ANN M (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: An Evidence-Based Leadership Training Intervention to Accelerate Integration of Behavioral Health and Primary Care

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Adoptive cellular immunotherapy utilizing T cells engineered with chimeric antigen receptor (CAR) has demonstrated lasting clinical responses in hematologic malignancies, but relapse remains a challenge. This K99/R00 project aims to precisely regulate the molecular dynamics of CAR and investigate its influence on CAR- T function. The innovative insights and versatile engineering approach proposed in this study will contribute to CAR engineering and novel CAR-T cell therapies.

PI_NAMEs: ZHOU, XIAOYU  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Address;Adoptive Immunotherapy;Amino Acids;Antigens;Biological Assay;C-terminal;CAR T cell therapy;career development;CD80 gene;Cell Physiology;Cells;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR-mediated transcriptional activation;CTLA4 gene;Cytoplasmic Tail;design;Disease;Elements;Endocytosis;engineered T cells;Engineering;Equilibrium;Faculty;Functional disorder;Genes;Genome engineering;Grant;Hematologic Neoplasms;Immune System Diseases;Immunology;Immunotherapy;improved;In Vitro;in vivo;innovation;insight;Investigation;knockout gene;Knowledge;Lysine;Mediating;Membrane;molecular dynamics;Mutate;Mutation;Nature;next generation;novel;novel strategies;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;Phase Transition;Population;Positioning Attribute;post-doctoral training;Proline;Proteins;receptor;receptor expression;receptor function;Receptor Signaling;Recycling;Regulation;Relapse;response;Role;Signal Transduction;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;TEV protease;Therapeutic Effect;Titrations;Toxic effect;trafficking;Transmembrane Domain;tumor;Tumor Antigens;Tyrosine;Work

PROJECT_TITLE: Reprogramming T cell function with multiplexed genome engineering to develop next-generation immunotherapy

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

PHR: PROJECT NARRATIVE Sleep disturbances are common in neurodevelopmental disorders and may increase risk or severity of disease. This proposal seeks to characterize the genetic, molecular, and cellular pathways controlling sleep during early life. Diverse and integrated research approaches will generate a deeper understanding of interactions between sleep and brain development in health and disease.

PI_NAMEs: KAYSER, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Adult;Affect;Behavioral;Biological Models;Brain;brain abnormalities;Cells;Characteristics;circadian;Coupling;design;Development;Disease;Drosophila genus;Genes;Genetic;genetic manipulation;Genetic Screening;Health;improvement on sleep;insight;interest;Knowledge;Life;Link;Maps;Molecular;neural circuit;Neurodevelopmental Disorder;Neurons;novel;novel therapeutics;Pathologic;Pathology;Pathway interactions;Pattern;programs;Property;Regulation;Regulatory Pathway;Research;Risk;Role;Severity of illness;Sleep;sleep abnormalities;Sleep Disorders;Sleep disturbances;sleep onset;sleep regulation;Work

PROJECT_TITLE: Investigating sleep regulation and function during early development

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (35)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Chicago

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Narrative: This project aims to provide a foundation for accelerating the development of microbiome therapeutics by systematically validating non-human primate animal models that can provide causal, mechanistic data regarding microbial impacts on host physiology. Specifically, it will improve the utility of longstanding non-human primate biomedical models for microbiome research by determining which non- human primate species model different taxonomic and functional features of the human gut microbiome and measuring the consistency of host-microbiome interactions across human and non-human primate species. Overall, the results will facilitate future studies targeting key questions about host-microbe interactions and disease in non-human primate models that, due to their genetic, physiological, and microbiomic similarities with humans, have a higher translational potential than mouse models.

PI_NAMEs: AMATO, KATHERINE RYAN (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Acceleration;Animal Model;Area;Attention;Behavioral;Biological Markers;Biological Models;Biology;Blood;Blood specimen;Callithrix;Cells;Cercopithecidae;Clinical;Clinical Research;Data;Development;Digestive Physiology;Disease;Enzyme-Linked Immunosorbent Assay;Etiology;Exhibits;Failure;Fishes;Foundations;Future;Genes;Genetic;Goals;gut microbiome;gut microbiota;Health;host microbiome;host-microbe interactions;Human;human data;Human Microbiome;human microbiota;human model;human subject;Immune;Immunity;improved;insight;Investments;Knowledge;Link;Macaca;Measures;Medical;Metabolic;Metabolism;metabolomics;Metagenomics;microbial;microbiome;microbiome composition;microbiome research;microbiome therapeutics;model organism;Modeling;mouse model;Mus;Night Monkey;nonhuman primate;Pan Genus;Papio;Pattern;Physiological;Physiological Processes;Physiology;Population;Primates;Production;Research;Research Personnel;Resources;Saimiri;Serum;Shotguns;stool sample;Taxonomy;Testing;Therapeutic;therapeutic development;trait;translational potential;Translational Research;translational study;Translations;United States National Institutes of Health;Variant;Volatile Fatty Acids

PROJECT_TITLE: Identifying non-human primate models for specific human microbiome traits

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Common viral respiratory infections, such as influenza and SARS-CoV-2, contribute to chronic lung disease. Following viral infection, airway repair mechanisms lead to differentiation of unexpected airway cell types within the lung, Microfold (M) and basal-like cells. This proposal will investigate the function of rare airway cell types during post-viral injury repair.

PI_NAMEs: BARR, JUSTINN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Aerosols;Air;airway epithelium;airway repair;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar fibrosis;Alveolus;Antibody Response;Antigens;Area;ATAC-seq;Bacterial Infections;Bioinformatics;Biological Assay;Biology;Bronchus-Associated Lymphoid Tissue;California;Cell Differentiation process;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;chemokine;Chromatin;Chronic;Chronic lung disease;Cicatrix;Communities;conditional knockout;Cre driver;Data;Distal;Environment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Epithelial Cells;Epithelium;experimental study;Future;Gases;Gene Expression;Genetic;Goals;Heterogeneity;Human;idiopathic pulmonary fibrosis;Immune;Immunologic Surveillance;Immunology;immunoregulation;in vivo;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;Inhalation;injured airway;Injury;injury and repair;Institution;Intestines;Knockout Mice;Lead;Lung;lung development;Lung Diseases;lung injury;lung repair;Lymphoid Follicle;M cell;Mentors;Mentorship;Molecular;Morbidity - disease rate;mouse model;mucosa-associated lymphoid tissue;Mucosal Immune Responses;mucosal site;Nasal Epithelium;Natural regeneration;Outcome;pathogen;Pathway interactions;Peyer's Patches;Physiology;Pneumonia;Postdoctoral Fellow;Predisposition;progenitor;programs;pulmonary function;Receptor Signaling;regenerative repair;regenerative therapy;Regulation;repaired;Research;resilience;Resolution;Resources;Respiratory System;Role;Secondary to;single nucleus RNA-sequencing;skills;Sorting;stem;stem cells;Submucosa;Surface;Surveys;Testing;Tissues;Tracheal Epithelium;Training;transcription factor;Universities;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Rare Airway Cell Function in Post-Viral Chronic Inflammation

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Non-Hodgkin lymphoma and chronic lymphocytic leukemia patients have immune system deficits that prevent them from developing appropriate immune responses to vaccines, placing them at high risk of severe infections and death. This proposal focuses on defining the responses of a type of immune system cell, namely T cells, after COVID-19 vaccination and infection in these patients. This will allow us to look for ways to improve the efficacy of vaccines in these and other immunosuppressed patients.

PI_NAMEs: CHANG, ANDRES  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;adaptive immune response;Antibodies;Antibody Response;antigen-specific T cells;Antigens;ATAC-seq;B cell therapy;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Biological Assay;Blood;Blood specimen;booster vaccine;cancer immunotherapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Therapy;Cells;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chromatin;Chronic Lymphocytic Leukemia;Clinical Data;cohort;Combined Modality Therapy;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;design;Development;Evolution;Functional disorder;Generations;Genetic Transcription;Goals;high risk;Immune response;Immune system;Immunocompromised Host;Immunologic Memory;immunosuppressed;Impairment;improved;Individual;Infection;Influenza;insight;Knowledge;Label;Laboratories;leukemia treatment;Life;lymph nodes;Lymphoma;Maintenance;Major Histocompatibility Complex;malignant lymphocyte;Malignant Neoplasms;Memory;Mentorship;Morbidity - disease rate;mortality;Non-Hodgkin's Lymphoma;novel;Nucleocapsid;patient population;Patients;Peptides;Phenotype;prevent;programs;Publishing;Recommendation;Research;response;RNA vaccine;Sampling;SARS-CoV-2 immune response;SARS-CoV-2 infection;Secondary Immunization;Serology;single cell sequencing;Stains;T cell receptor repertoire sequencing;T cell response;T-Cell Lymphoma;T-Lymphocyte;Technology;therapeutic vaccine;therapy design;Tissue Sample;Vaccinated;Vaccination;vaccine efficacy;vaccine immunogenicity;vaccine response;Vaccinee;Vaccines;Variant;Viral;Virus;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: SARS-CoV-2 immune responses in patients with lymphoma

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease;Pain Research;Patient Safety;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Nearly 30% of Emergency Department patients with chest pain have undiagnosed and/or unmanaged high cholesterol, which represents an opportunity for Emergency Medicine providers to improve health for the 8-10 million patients who receive care in an Emergency Department each year for chest pain. This study will address a critical gap in knowledge by determining the efficacy of an Emergency Department-driven cardiovascular disease prevention program that aims to identify and treat patients with high cholesterol. This is a highly significant and innovative study as it evaluates the first Emergency Department-based preventive cardiovascular care approach for high cholesterol, which could also be applicable to other cardiovascular disease risk factors among Emergency Department patients.

PI_NAMEs: ASHBURN, NICKLAUS  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adherence;American;arm;Atherosclerosis;atherosclerosis risk;Cardiac Death;Cardiology;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care systems;career development;Caring;Chest Pain;Cholesterol;Clinical Trials;Clinical Trials Design;comparative efficacy;Consolidated Framework for Implementation Research;Counseling;Data;design;Development Plans;Diabetes Mellitus;Dimensions;efficacy evaluation;efficacy outcomes;efficacy testing;efficacy trial;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Enrollment;Environment;Event;follow-up;Goals;Guidelines;Health;healthy lifestyle;Heart Diseases;Hematological Disease;High Prevalence;Hyperlipidemia;implementation determinants;improved;innovation;Interdisciplinary Study;Intervention;Interview;Knowledge;LDL Cholesterol Lipoproteins;Life Style;lipid disorder;Lipids;Lung Diseases;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;novel diagnostics;novel therapeutic intervention;Nurses;Outpatients;Patient Compliance;Patient Selection;Patients;Persons;Physician Executives;Physicians;Positioning Attribute;prevent;Prevention program;Preventive;Preventive care;Primary Care;primary outcome;Professional Organizations;Program Development;programs;prospective;Provider;Qualitative Methods;Randomized;Recommendation;Research;Research Personnel;Research Proposals;Research Training;Risk;Risk Assessment;Risk Factors;screening program;secondary outcome;Senior Scientist;Side;Site;skills;Sleep Disorders;Structure;Surveys;Testing;Theoretical Domains framework;therapy design;Training;treatment as usual;treatment program;United States Dept. of Health and Human Services;United States Preventative Services Task Force;Universities;Visit;Work

PROJECT_TITLE: Initiating Preventive Care for Hyperlipidemia in the Emergency Department: The EMERALD Trial

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Endocannabinoid System Research;Hematology;Neurosciences;Nutrition;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Therapeutic Cannabinoid Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Globally, Sickle Cell Disease (SCD) is prevalent in resource-limited settings and plagued by malnutrition including for individuals living in the United States. Our goal is to identify the multigenerational effects of diet and cannabinoid exposure in the initiation and progression of pain in SCD using humanized transgenic sickle mice which show the pathobiology and features of pain similar to persons with SCD. High-throughput data and mechanisms examined herein will pave the way for clinical studies of integrative approaches to improve pain related outcomes in SCD.

PI_NAMEs: ARGUETA, DONOVAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;Address;adverse outcome;Affective;African American population;Age;Agonist;Analgesics;analog;anandamide;Applications Grants;Area;behavior measurement;Behavioral;Birth;Brain;Brain region;Breeding;Cannabidiol;cannabinoid receptor;Cannabinoids;cell type;Chronic;Chronic Disease;chronic pain;chronic pain management;Clinical;Clinical Research;CNR1 gene;Cognitive;cognitive function;Collaborations;comorbidity;Data;Detection;Development;Diet;dietary;Dietary Intervention;dietary manipulation;Discrimination;Dopamine;dopaminergic neuron;dorsal horn;Dose;effective therapy;Endocannabinoids;endogenous cannabinoid system;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Evaluation;experience;Eye;Fatty acid glycerol esters;Female;Gene Expression;Goals;Head circumference;Health;Health Benefit;Hematological Disease;Hematopoietic Stem Cell Transplantation;hydroxyurea;Hyperalgesia;Hypersensitivity;immunoreactivity;improved;Individual;infancy;Inherited;insight;Intervention;Latin American;Learning;Length;Life;male;Malnutrition;Mass Spectrum Analysis;Mentors;midbrain central gray substance;Mus;neuroimaging;Neurons;Neurotransmitters;Nociception;novel;Nutrient;nutrition;Nutritional;Obesity;offspring;Omega-3 Fatty Acids;Opioid;opioid therapy;opioid use;Outcome;Pain;pain inhibition;pain outcome;pain reduction;pain signal;Parents;Pathologic;Pathway interactions;Perception;Perinatal;Persons;Phase;Play;Positron-Emission Tomography;Posterior Horn Cells;postnatal;Pregnancy;prevent;Prevention;Property;prospective;Resource-limited setting;Resources;Rewards;Risk;Role;Sensory;Serotonin;Sickle Cell Anemia;Sickle Cell Trait;sickling;Signal Pathway;Signal Transduction;skills;Social isolation;social stigma;somatosensory;Spinal cord posterior horn;standard of care;Synapses;Techniques;Teratogenic effects;Teratogens;Tetrahydrocannabinol;Tissues;Training;transcriptomics;Transgenic Organisms;translational potential;treatment response;United States;Ventral Tegmental Area;Vulnerable Populations;Weaning

PROJECT_TITLE: Nutrition-based interventions to ameliorate pain in sickle cell disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Pediatric;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse;Violence Research;Youth Violence

PHR: PROJECT NARRATIVE While substance problems and associated externalizing behaviors (i.e., violence, delinquency) have a significant negative impact on health and development, empirically-supported treatments are time- and resource-intensive, placing a high burden on youth and families engaged in treatment as well as the therapists providing these services. The training and research described in this proposal will examine how neural, genetic, and environmental risk factors for early substance use problems are modified by and associated with Multisystemic Therapy treatment outcomes. This project has the potential to establish novel approaches to evaluating the impact of targeted treatment on mechanisms that contribute to severe and persistent substance use, with the long-term goal of improving treatment outcomes for high-risk youth.

PI_NAMEs: BRISLIN, SARAH  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Adolescent;adolescent substance use;Aftercare;antisocial behavior;Applications Grants;Award;Behavioral;Brain;Caregivers;Clinical;Clinical Investigator;clinical practice;Clinical Research;cognitive development;community based treatment;Complement;Data;Data Analyses;Data Collection;Data Reporting;Development;emotional functioning;Enrollment;Environment;Environmental Risk Factor;Etiology;Exhibits;externalizing behavior;Family;family support;Future;Genetic;Genetic Risk;genetic risk factor;Goals;Grant;Health;high risk;improved;indexing;Individual Differences;Knowledge;Measures;Methods;multimodality;Neighborhoods;neural;neural network;neuroimaging;neuromechanism;Neurophysiology - biologic function;Neurosciences;novel strategies;Outcome;patient oriented;peer;phenotypic data;Problem behavior;Process;programs;psychogenetics;Research;Research Personnel;Research Project Grants;Resistance;Resources;response;Rest;Rewards;Risk;Risk Marker;Sampling;Services;severe behavior problem;Siblings;skills;social health determinants;substance use;substance use treatment;System;Systemic Therapy;targeted treatment;Testing;Time;Training;Training Support;Translating;Translational Research;transmission process;Treatment outcome;treatment research;Violence;Work;Youth

PROJECT_TITLE: Neural, genetic, and environmental indicators of treatment outcomes for adolescent substance use

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Natural Products;Neurosciences;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative We aim to investigate the effects of cannabinoids and opioids for modulating pain, reward, and opioid use. Novel neuroimaging, behavioral and self-administration assays will allow us to study interactions between pain and reward pathways and evaluate the effects of these drugs on these systems.

PI_NAMEs: CAUDLE, ROBERT M;NEUBERT, JOHN K (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acquired Immunodeficiency Syndrome;Acute;Acute Pain;Affect;Analgesics;Animals;Anorexia;Attention;Attenuated;Behavior;Behavior assessment;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Brain;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;chemotherapy;Chronic;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Trials;clinically relevant;Collaborations;comorbidity;Controlled Study;cost;Data;Dependence;Depressed mood;Disease;Dose;Dronabinol;drug discovery;Epidiolex;Euphoria;experimental study;Failure;Foundations;Future;Goals;heuristics;Human;human subject;Individual;innovation;Legal;Maps;Measures;Medical Marijuana;Modeling;Motor;multidisciplinary;Multiple Sclerosis;Mus;Nabilone;Nausea;neural;Neurobiology;neuroimaging;Neurosciences;novel;novel strategies;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid sparing;opioid use;Outcome;Outcome Measure;Oxycodone;oxycodone self-administration;Pain;pain behavior;Pain Clinics;pain inhibition;Pain management;Pain Measurement;pain model;pain reduction;pain relief;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Placebo Effect;pre-clinical;prescription opioid;programs;Property;Psychological reinforcement;Public Health;PubMed;Rattus;Recreational Drugs;Reflex action;Reporting;Research;response;Rewards;Risk;Rodent;Sedation procedure;Seizures;Self Administration;side effect;Societies;substance use;Substance Use Disorder;synergism;System;Tail;Testing;Tetrahydrocannabinol;Translating;Translations;Variant;Ventilatory Depression

PROJECT_TITLE: Opioid and cannabinoid interactions in pain and reward

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Precision Medicine;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Lumbar spine disease is one of the most disabling health problems worldwide and is impacted by a variety of psychosocial influences that are rarely incorporated into surgical decision-making. Mobile health technology has created newfound opportunities for capturing real-time measures related to pain, physical function, and psychosocial health. By leveraging these novel tools, this study will lay the foundation for delivering personalized perioperative treatments that improve lumbar surgery outcomes by addressing individualized risk factors identified using mobile health assessments.

PI_NAMEs: GREENBERG, JACOB  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;advanced analytics;Award;Behavior Therapy;Behavioral;Biochemical;Biometry;biopsychosocial;chronic pain;Clinical;Cognitive;Cognitive Therapy;cohort;comorbidity;Complement;Complex;Data;Data Analytics;data integration;Data Set;Decision Making;Degenerative Disorder;Dimensions;disability;Disabling;Disease;disease phenotype;Ecological momentary assessment;efficacy testing;Etiology;Evaluation;evidence base;Evidence based treatment;Feedback;fitbit;fitness;Foundations;Goals;Grouping;Health;health assessment;Health Technology;Heart Rate;Hospitals;Impairment;implementation context;implementation science;improved;improved outcome;Individual;individualized medicine;innovation;insight;Intervention;Interview;Low Back Pain;Machine Learning;machine learning method;machine learning model;Measures;Mental Health;Mentors;Methods;mHealth;Modeling;Monitor;Moods;multidisciplinary;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;Pain;Pain in lower limb;Pain Measurement;pain model;Pain Research;pain symptom;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Perioperative;personalized approach;personalized decision;personalized medicine;Phenotype;Physical Function;Physiological;prevent;Prognosis;prognostic;prognostic value;prognostication;programs;psychologic;Psychological Factors;psychosocial;Psychosocial Influences;Questionnaires;randomized trial;rapid growth;Recommendation;Reporting;Research;Research Activity;Risk Assessment;Risk Factors;Role;Sleep;social factors;social influence;Spinal Diseases;Spine surgery;Structure;Surgeon;surgery outcome;Surgical Management;Surveys;Symptoms;Techniques;Technology;Testing;therapy development;Time;tool;Training;Training Programs;treatment planning;treatment response;treatment strategy;United States;Variant;Vertebral column

PROJECT_TITLE: Using Mobile Health Technology and Real-Time Assessments to Address Multilevel Influences on Lumbar Spine Surgery Outcomes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research and career development are relevant to public health because acute lower respiratory infections (ALRI) are the leading cause of death amongst children under 5 years old worldwide. When implemented in healthcare settings in sub-Saharan Africa pulse oximetry is known to reduce child ALRI mortality, but there is limited uptake due to lack of health system investment and healthcare worker concerns about its accuracy and effects on clinical workflows. Increased pulse oximetry use in child ALRI care in sub- Saharan Africa is critical to reducing associated mortality.

PI_NAMEs: HOOLI, SHUBHADA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 5 year old;Acute;Address;Affect;Africa;Africa South of the Sahara;African;Ambulatory Care;Ambulatory Care Facilities;barrier to care;Behavior Therapy;Black race;Blood;Blood gas;career;career development;Caring;Cause of Death;Cellular Phone;Cessation of life;Child;Child Mortality;Childhood;Classification;Clinical;clinical care;clinical predictors;Clinical Research;Clinical Trials;Clip;Cognitive Dissonance;Complex;cost;Cost Analysis;cost comparison;cost effective;Costs and Benefits;Coupled;Critical Care;Darkness;Data;Data Set;design;Devices;Early identification;Education;education planning;Emergency Medicine;Equity;experience;Fingers;Foundations;Funding;Future;global health;Goals;Government;Health;health care settings;Health Personnel;Health system;High Prevalence;Hospitalization;Hypoxemia;implementation cost;implementation science;improved;Individual;innovation;International;Intervention;Investments;Length of Stay;low and middle-income countries;Lower Respiratory Tract Infection;Malawi;Measurement;Measures;Mentors;Mentorship;Methods;Mission;mortality;mortality risk;National Heart, Lung, and Blood Institute;Outcome;Outpatients;Output;Oxygen;Oxyhemoglobin;Parents;Patient Focused Care;patient oriented research;Patients;pediatric emergency;Pediatric Hospitals;Peripheral;Physicians;Physiologic pulse;Pneumonia;Population;predictive tools;Prospective Studies;Public Health;Pulse Oximetry;Quality of Care;racial health disparity;Recommendation;Reference Standards;Reporting;Research;research and development;Research Design;Research Personnel;research to practice;Retrospective Studies;Role;routine care;Scientist;Sentinel;Shapes;skills;Skin;South Africa;success;synergism;temporal measurement;Testing;Texas;Time;Time Perception;time use;Translational Research;Trust;United States;United States National Institutes of Health;uptake;Visit;Work;World Health Organization

PROJECT_TITLE: Pulse Oximetry Accuracy and Integration into Pediatric Outpatient Care in South Africa


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Neurosciences;Pediatric

PHR: Project Narrative  This research aims to identify functional connectivity (FC) markers of disease for Chiari Malformation (CM), a condition characterized by an anatomic abnormality of the cerebellar tonsils and manifests in a wide range of often non-specific neurologic symptoms. The results will advance the fundamental understanding of how structural abnormalities in the human brain affect FC and provide translational evidence for use of FC in predicting treatment outcomes. This proposal will also serve as a model for studying human subjects who are treated for neurologic disorders associated with structural abnormalities for the long-term goal of clinical application to improve health care.

PI_NAMEs: ROLAND, JAROD  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 10 year old;18 year old;Abnormal coordination;Address;Adolescent;Affect;Age;Anatomy;associated symptom;Attention;Brain;career;career development;Cerebellar tonsil;Cerebellum;Cerebral cortex;Cerebrum;Characteristics;Child;Childhood;Clinic;Clinical;clinical application;clinical care;clinical phenotype;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive neuroscience;cognitive testing;cohort;Communication;Data;Data Analyses;Data Collection;Data Set;data sharing;Deformity;design;Development;Dimensions;Disabling;Disease;Disease Marker;Disparity;Enrollment;Executive Dysfunction;executive function;experience;foramen magnum;Functional disorder;Functional Magnetic Resonance Imaging;Future;General Population;Goals;Headache;Health;Healthcare;Human;human subject;Image;Image-Guided Surgery;Impaired cognition;improved;indexing;Individual;Intervention;Interventional Imaging;Knowledge;Language;Link;Literature;Magnetic Resonance Imaging;malformation;Measures;Mechanics;Memory;Methodology;Methods;Motor;National Institute of Neurological Disorders and Stroke;Natural History;Neck Pain;Nervous System Disorder;network dysfunction;Neurobehavioral Manifestations;neuroimaging;Neurologic;Neurologic Symptoms;Neurosurgeon;neurosurgery;novel;novel marker;Operative Surgical Procedures;Outcome;Paresthesia;Participant;Pathologic;Pathology;Pathway Analysis;Patient Care;Patients;Pediatrics;Positioning Attribute;post intervention;Posterior Fossa;potential biomarker;Prediction of Response to Therapy;prospective;Prospective cohort;protocol development;recruit;Reporting;Research;response;responsible research conduct;Rest;Role;Sampling;Severities;Sorting;Standardization;standardize measure;Structural defect;Structure;Study models;Surface;symptom treatment;Symptoms;Time;time interval;Tonsil;Training;Translating;translational potential;treatment comparison;treatment effect;Treatment outcome;treatment response;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Functional Connectivity Markers of Cognitive Network Disfunction in Chiari Malformation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Despite the proliferation of local retail policies to curb tobacco use, the impact of these policies on disparities in tobacco outcomes remains unclear. This evaluation study, which uses advanced statistical methods has three primary goals: 1) describe and examine the impact of local TRL laws and fees on sociodemographic differences in retailer density by area-level race/ethnicity, income, and education; 2) explain and measure the impact of local FTP restrictions on sociodemographic differences in product sales within the communities by area- level race/ethnicity, income, and education; and 3) visualize and investigate the interactive effect of both policies on sociodemographic differences in individual-level exclusive and dual youth and adult cigarette and e-cigarette use using spatial and causal inference modeling. These study findings provide insight into future directions for tobacco retail policymaking to help curb the tobacco epidemic within the communities.

PI_NAMEs: USIDAME, OMOBUKOLA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Adopted;Adult;advanced analytics;Advertisements;American Indians;American Lung Association;Area;Award;Black Populations;Budgets;California;Cancer Etiology;career;Case Study;Characteristics;Cigarette;Communities;Computer software;Data;Demographic Impact;density;design;Disparity;Disparity population;Education;electronic cigarette use;empowerment;Environment;Epidemic;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation Studies;Fees;Foundations;Future;Geography;Goals;Grant;Health;health disparity;health equity;Income;Individual;insight;Interview;Investments;K-Series Research Career Programs;Laws;Licensing;low socioeconomic status;Marketing;Measures;Mentors;Methodology;Methods;Minority;Minority Groups;Modeling;multiple data sources;Neighborhoods;Outcome;outcome disparities;Persons;Policies;Policy Analysis;Policy Maker;Policy Making;Population Group;Prevalence;preventable death;Principal Investigator;programs;Proliferating;public policy on tobacco;Race;racial difference;racial disparity;racial minority;Research;Research Personnel;Sales;skills;Smoking;smoking prevalence;sociodemographic disparity;sociodemographic group;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;Solid;Statistical Methods;Stratification;Surveys;System;Techniques;Testing;Tobacco;tobacco control;tobacco flavor;Tobacco Industry;tobacco products;Tobacco use;Training;Visualization;Youth

PROJECT_TITLE: Examining the Impact of Local Policies on Sociodemographic Disparities in Tobacco Use


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Project Narrative The goal of this work is to examine if transcranial direct current stimulation (TDCS), paired with training in the emotional regulation strategy of reappraisal, may enhance regulation of craving (measured with self-report and EEG) in individuals with Cannabis Use Disorder (CUD) and result in clinical reduction of cannabis use as measured by ecological momentary assessment (EMA). Sixty participants with CUD will be randomized to either real or sham DLPFC stimulation in 5 20-minute TDCS and reappraisal training sessions one week apart using a double-blind design, with EEG sessions at the first and final visit, and participants will report daily cannabis use with EMA. Findings will serve important proof-of-concept data on the clinical effectiveness of TDCS as an augment for CUD treatment.

PI_NAMEs: CROWLEY, MICHAEL J;POTENZA, MARC N (contact);STEELE, VAUGHN R

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Action Potentials;addiction;Addictive Behavior;Affect;Aftercare;Anodes;Behavior;Behavior Therapy;Cannabis;cannabis craving;Clinical;Clinical effectiveness;Cognitive Therapy;Country;Coupled;craving;Cues;Data;design;Development;Disease;Double-Blind Method;Ecological momentary assessment;effective therapy;Effectiveness;Electroencephalography;emotion regulation;Evidence based treatment;follow-up;Food;Future;Goals;Image;improved;Individual;innovation;interest;Internet;Investigation;Laboratories;Left;Legal;Literature;Location;longitudinal design;marijuana legalization;marijuana use;marijuana use disorder;Measures;Meta-Analysis;Methods;Mindfulness Training;Motivation;neural correlate;Participant;Patient Self-Report;Pattern;Persons;Prediction of Response to Therapy;Prefrontal Cortex;Prevalence;Randomized;recruit;Regulation;Reporting;response;Sampling;skills;substance use;success;Techniques;therapy design;Time;tool;Training;transcranial direct current stimulation;transmission process;Use Effectiveness;Visit;Work

PROJECT_TITLE: Examination of potential effectiveness of transcranial direct current stimulation (TDCS) paired with reappraisal training for Cannabis Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE The etiology of central serous chorioretinopathy (CSC) and associated choroidal anatomy is poorly understood and could be better understood through discovery of genetic risk factors. Despite its being the 4th most common maculopathy, its substantial morbidity in a younger population and its phenotypic and genetic overlap with age-related macular degeneration (AMD), CSC lacks pathophysiologic understanding and treatment options. Discovery of the genetic underpinnings of CSC and choroidal thickening (and how they relate to those of AMD) could lead to a better understanding of the pathophysiology of CSC, and it could point to molecular pathways on which to intervene.

PI_NAMEs: ROSSIN, ELIZABETH JEFFRIES (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Age;Age related macular degeneration;Anatomy;Area;automated algorithm;automated segmentation;biobank;Biological;Blindness;Blood Vessels;Caliber;career;Categories;Characteristics;Choroid;Choroid Diseases;Clinical;clinical research site;cohort;Collaborations;Complement;Critical Pathways;Data;Data Set;design;Diagnosis;diagnostic technologies;Disease;disorder of macula of retina;Doctor of Philosophy;Etiology;experience;Fostering;Functional disorder;Genetic;genetic association;Genetic Research;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome wide association study;genomic locus;Genotype;Hand;Heritability;Image Analysis;improved;Individual;Japan;Learning;Learning Skill;Link;Liquid substance;Machine Learning;macula;Manuals;Measurement;Measures;men;Mentors;Meta-Analysis;Modernization;Molecular;Morbidity - disease rate;novel;Optical Coherence Tomography;Pathway interactions;patient oriented;Patient Recruitments;Patients;Phenotype;Population;prospective;Prospective cohort;Publishing;Quality Control;recruit;Reporting;Research;Resources;Retina;Retinal Diseases;Sample Size;Scientist;Serous;Services;sex;skills;Source;Specialist;statistics;Steroids;Stress;Techniques;Testing;Thick;Training;Training Programs;trait;Universities;Variant;Visual Acuity;Work

PROJECT_TITLE: Genetics of central serous chorioretinopathy and choroidal thickening

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Currently it is unknow if the reduced carnosine and increased toxic acrolein reported in AD patients and in murine models of AD reflects a cause or a consequence of disease progression. This gap in our knowledge is caused partially by lack of appropriate experimental models. We will generate and characterize new mouse models to answer this long-standing question.

PI_NAMEs: ELBAZ-EILON, BENAYAHU  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Ablation;Acrolein;adduct;Affect;age related;aged;Aging;Aldehydes;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid deposition;amyloid pathology;Animals;Area;behavioral study;Binding;Body Fluids;Brain;Breeding;Carnosine;Cells;Core Facility;Data;Development;Disease;Disease Marker;Disease Progression;DNA;Drug Metabolic Detoxication;Ensure;Enzymes;Etiology;experience;Experimental Models;Food Supplementation;Funding;Future;Genetic;Genetic Recombination;Genetic study;Grant;Heart Abnormalities;Human;Inflammation;interest;Investigation;Knowledge;Link;Lipid Peroxidation;Lipids;macromolecule;Mediating;Metabolic Pathway;Microglia;Modeling;mouse model;Mus;Mutation;Myelin;Names;Nerve Degeneration;new therapeutic target;normal aging;Oligodendroglia;Pathogenesis;Patients;Play;pre-clinical;Production;Proteins;Reporting;Research;RNA;Role;Source;sperm cryopreservation;Tamoxifen;tool;Toxic effect;toxicant;Training

PROJECT_TITLE: Development of new tools to explore the role of oligodendrocyte-derived carnosine in Alzheimer Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Lung;Physical Activity;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a progressive disease with high morbidity and mortality; physical activity limitations are the most common initial presentation. The current research will be the first step in integrating cardiopulmonary measures with physical activity to phenotype patients, investigating the correlation of these phenotypes with clinical outcomes in PAH, and understanding patients’ attitudes and preferences for activity-based interventions. This work will set the stage for a trial of interventions promoting preferred exercise patterns, eventually allowing personalized activity-based prescriptions in PAH.

PI_NAMEs: MINHAS, JASLEEN  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accelerometer;actigraphy;Address;adverse outcome;Agreement;Attitude;Award;Behavior Therapy;Biological Markers;Biosensor;Cardiopulmonary;career development;Career Mobility;Caring;Cessation of life;Characteristics;Clinic;Clinical;cohort;Complex;Critical Care;Data;Data Analyses;data streams;Defect;design;Development;Development Plans;Devices;dimension reduction;Disease;Electrocardiogram;Emergency department visit;Enrollment;Ensure;Environment;Event;Exercise;exercise capacity;Female;Future;General Population;Goals;health related quality of life;Heart Rate;heart rate variability;high body mass index;Hip region structure;Home;Home environment;Hospitalization;human old age (65+);improved;improved outcome;Individual;individual variation;innovation;insight;Intervention;Intervention Trial;Interview;Investments;Joints;Knowledge;Lung;Measurement;Measures;Mentors;Methodology;Methods;Monitor;Morbidity - disease rate;mortality;multidimensional data;multimodal data;novel;Older Population;operation;Outcome;Parents;Patient Preferences;Patient-Focused Outcomes;Patients;Pattern;Pennsylvania;personalized intervention;Phenotype;Physical activity;Physicians;Physiological;Physiology;Population;Positioning Attribute;preference;Principal Component Analysis;prognostication;Progressive Disease;Prospective Studies;Prospective, cohort study;pulmonary arterial hypertension;Qualitative Methods;Research;Research Personnel;respiratory;Right Ventricular Dysfunction;Risk;Scientist;sedentary lifestyle;Severities;Severity of illness;Site;skills;Statistical Methods;Structure;success;Techniques;Testing;Time;Training;treatment response;Universities;Variant;Walking;Work

PROJECT_TITLE: Physical activity phenotypes and their association with traditional outcomes in pulmonary arterial hypertension


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biomedical Imaging;Chronic Pain;Clinical Research;Neurosciences;Pain Research;Prevention;Psoriasis

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Psoriatic arthritis (PsA) is a chronic, immune-mediated disease characterized by widespread skin and musculoskeletal inflammation that affects up to 1% of the population leading to joint swelling, disability and pain. While the use of biologic therapies and other novel treatments has significantly improved the lives of many people with PsA, more than 50% of patients do not respond adequately to these medications and persistent joint pain often remains intractable and a major driver of poor clinical outcomes. Successful completion of our proposed studies will characterize the prevalence and drivers of persistent joint pain, identify changes in brain connectivity that correlate with persistent pain, and develop a predictive model of persistent pain in newly diagnosed, medication naïve patients in order to design adjuvant treatment strategies for pain amelioration and improvement in overall clinical outcomes.

PI_NAMEs: HABERMAN, REBECCA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Achievement;Acute-Phase Proteins;Adjuvant Therapy;Affect;Ankylosing spondylitis;Anti-Rheumatic Agents;Applications Grants;Area;Arthralgia;Arthritis;arthropathies;Award;behavioral health;Biological;Biological Response Modifier Therapy;Biometry;Brain;brain magnetic resonance imaging;career;career development;Cementation;central pain;Chronic;Clinical;clinical investigation;clinical phenotype;Clinical Trials;cohort;Complex;Data;Dedications;design;Development;Development Plans;disability;Disease;Disease remission;Epidemiologic Methods;Epidemiology;experience;Exposure to;Extramural Activities;Fatigue;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;IL17 gene;Image;Immune;immunomodulatory therapies;improved;improved outcome;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory pain;inhibitor;innovation;Insula of Reil;interleukin-23;Intervention;Intervention Trial;joint inflammation;joint injury;Joints;Journals;Location;Magnetic Resonance Imaging;Master of Science;Measures;Mechanics;Mediating;medical schools;memory process;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;Musculoskeletal;Nail plate;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;neuroimaging;Newly Diagnosed;novel;novel therapeutic intervention;Outcome;Outcomes Research;Pain;Pain Measurement;pain perception;pain processing;Participant;patient population;Patients;Peripheral;Persistent pain;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Population;Positioning Attribute;Predictive Factor;predictive modeling;Prevalence;prevent;Process;professor;Psoriasis;Psoriatic Arthritis;psychologic;Psychological Factors;Publications;recruit;Reporting;Research;Research Personnel;Resolution;Resources;response;Rest;reward processing;Rheumatoid Arthritis;Rheumatology;sensory input;skills;Skin;Sleep disturbances;Statistical Models;success;Swelling;Symptoms;Synovitis;tenure track;Therapeutic;Titrations;TNF gene;tool;Training;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical and neuroimaging determinants of persistent joint pain in psoriatic arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M2)]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Nutrition;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In spite of significant advances in medical therapeutic options for Crohn’s disease (CD), there are currently no strategies for prevention of this chronic, disabling inflammatory disease. This project will delineate the impact of dietary and lifestyle modification on preventing CD development in high-risk individuals, and conduct the first interventional study to assess the feasibility and effect of personalized risk disclosure and risk-factor counseling as a tool to reduce behaviors and biomarkers associated with CD development in unaffected first- degree relatives. Such work addresses a critical gap in the field of CD prevention and provides a foundation for future strategies to reduce CD burden in high-risk populations.

PI_NAMEs: LOPES, EMILY WALSH (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Academic advising;academic standard;Address;Adherence;Adult;Advisory Committees;Affect;Age;Award;Behavior;Behavioral;Biological;Biological Markers;burden of illness;C-reactive protein;career development;CD11 Antigens;CD6 antigen;Chronic;Clinical;Clinical Investigator;Colitis;Conduct Clinical Trials;Consumption;Counseling;Crohn's disease;Data;Dedications;design;Development;Development Plans;didactic education;Diet;Diet Modification;dietary;Dietary Factors;Disabling;Disclosure;Disease;disorder prevention;disorder risk;economic impact;Education;Environment;Epidemiology;Europe;Feasibility Studies;feasibility testing;First Degree Relative;Flax;Follow-Up Studies;Foundations;fruits and vegetables;Funding;Future;Gastroenterology;General Hospitals;genetic variant;Genotype;Goals;good diet;Grant;Health Professional;healthy lifestyle;high risk;high risk population;immune activation;Immune response;Immunologic Markers;Immunologics;immunoreactivity;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;insight;Intervention;Intervention Studies;Intestinal permeability;Leukocyte L1 Antigen Complex;Life Style;Life Style Modification;lifestyle factors;lifestyle intervention;lifetime risk;Massachusetts;Mediating;Medical;Mentorship;Methodology;microbiota;mortality;Motivation;novel;Nurses' Health Study;nutrition;nutritional epidemiology;Online Systems;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;physical inactivity;Pilot Projects;polygenic risk score;pre-clinical;Predisposition;prevent;Prevention;Prevention strategy;Prospective cohort;Prospective Studies;Proxy;Public Health Schools;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Relative Risks;Research;retention rate;Risk;Risk Estimate;Risk Factors;Risk Reduction;Role;Saccharomyces cerevisiae;skills;small molecule inhibitor;Smoking;Social Impacts;specific biomarkers;Symptoms;Testing;Therapeutic;TNFRSF8 gene;tool;Training;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Prevention of Crohns Disease in High-Risk Individuals

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), is the tumor virus that causes Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease in individuals with acquired immunodeficiency. It remains largely unknown how antiviral selective autophagy is activated by and responds to pathogenic HHV-8 productive replication, but our preliminary studies have shown that the autophagy-related protein LC3B plays a key role in the first line of host defense, potentially by mediating nuclear export of viral DNA for autophagic degradation and type III interferon gene expression. This proposed study will reveal the molecular mechanisms and functional significance of LC3B regulation of viral DNA in HHV- 8 infection and thereby provide a molecular basis for future studies of viral regulation of antiviral autophagy and therapeutic targeting in HHV-8 diseases.

PI_NAMEs: CHOI, YOUNG BONG  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: acquired immunodeficiency;Anti-viral Response;Autophagocytosis;Binding;Biological;Biological Assay;Bulla;Cell Line;Cell Nucleus;cell type;Cells;cellular targeting;Classification;Complex;Custom;Cytoplasm;Data;Detection;Disease;DNA;Etiology;Excision;Family;Fractionation;Future;G22P1 gene;gammaherpesvirus;Gene Expression;Genes;Genetic study;Genome;Growth;HIV-1;Host Defense;Housekeeping;Human;Human Herpesvirus 8;immunodeficiency;Immunosuppressive Agents;In Situ;Individual;Infection;inhibition of autophagy;Innate Immune Response;Interferon Type II;Interferons;Kaposi Sarcoma;Knock-out;knockout gene;Knowledge;Literature;Lymphoma cell;Lytic;lytic gene expression;Lytic Phase;lytic replication;Malignant Neoplasms;Mediating;member;Methods;Microscope;mitochondrial autophagy;Molecular;Multicentric Angiofollicular Lymphoid Hyperplasia;Mutagenesis;Nuclear;Nuclear Export;Oncogenic Viruses;Organelles;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Play;Ploidies;primary effusion lymphoma;Productivity;protein aggregation;Protein Family;Proteins;receptor;reconstitution;Regulation;response;Role;sensor;Signal Pathway;Structure-Activity Relationship;System;Terminal Repeat Sequences;Testing;therapeutic target;ultra high resolution;Up-Regulation;Variant;Viral;viral DNA;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Role of LC3B in Host Defense against Human Herpesvirus 8 Lytic Replication

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: ABO(H) blood group antigens were the first human polymorphisms described and corresponding anti-ABO(H) antibodies continue to be the most common immunological barrier to transfusion and transplantation. However, despite their discovery over a century ago, the factors responsible for anti-ABO(H) antibody development remain relatively unknown. Using a series translational studies coupled with a new preclinical model of anti-blood group antibody formation, we will define key factors that influence the overall levels and specificity of anti-ABO(H) antibodies.

PI_NAMEs: WU, SHANG-CHUEN  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: ABO blood group system;Address;Adverse event;Antibodies;Antibody Formation;Antibody Repertoire;Antibody titer measurement;antimicrobial;B-Lymphocytes;Binding;blood group;Blood Group Antigens;Blood Group Incompatibility;Blood typing procedure;Carbohydrates;career;Clinical;clinically significant;Coupled;Data;design;Development;Erythrocytes;Exhibits;Exposure to;Foundations;Galactose Binding Lectin;Genetic Polymorphism;Glycobiology;Goals;Human;human subject;Immune;Immunobiology;Immunologic Factors;Immunologics;Immunology;Impairment;In Vitro;in vivo;Individual;inhibitor;insight;Knock-out;Knockout Mice;Lectin;Life;Lipopolysaccharides;Mediating;Microbe;microbial;Microbiology;microbiota;Modeling;Mus;Natural Immunity;Outcome;Phase;Play;Polysaccharides;Population;Pre-Clinical Model;prevent;Production;Reaction;Role;Series;Shapes;Specificity;Structure;Surface;Testing;Tissue Transplantation;tool;Training;Transfusion;transfusion medicine;translational study;Transplantation;Variant

PROJECT_TITLE: Uncovering the Impact of Innate Immunity on Transfusion Medicine Immunobiology


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Teenage Pregnancy;Telehealth;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This project will study virtual delivery of Safe Dates for Teen Mothers, a 10-session, group-based intimate partner violence prevention program tailored for teen girls who are pregnant or parenting. This program has the potential to improve the health and well-being of teen mothers and their children, and virtual delivery may improve teens’ ability to attend. This study will examine the feasibility and preliminary effects of delivering the program using a virtual approach to determine whether this approach should be used by practitioners and tested for effectiveness in a larger study.

PI_NAMEs: KAN, MARNI L (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Age;aged;attentional control;Behavior;Birth;Birth Rate;Black race;Child;Child Rearing;Child Welfare;community based evaluation;cost;County;Data;Development;Education;effectiveness testing;efficacy trial;emotional abuse;evidence base;Evidence based intervention;experience;feasibility testing;follow-up;Funding Agency;Future;Geography;girls;Goals;Health;Health education;Health Services;help-seeking behavior;High Prevalence;implementation evaluation;implementation outcomes;improved;Individual;Intervention;intervention participants;Interview;intimate partner violence;Latinx;Maternal and Child Health;Measures;Methods;multidisciplinary;North Carolina;Outcome;parenting intervention;Parents;Participant;perpetrators;Personal Satisfaction;Persons;Population;Population Programs;Pregnancy;pregnant;pregnant teen;prevent;Prevention;Prevention program;preventive intervention;Principal Investigator;programs;psychologic;Randomized;randomized trial;Randomized, Controlled Trials;recruit;reproductive coercion;Research;Research Personnel;rural area;scale up;sexual assault;Site;Surveys;Target Populations;Technology;teen birth;teenage mother;teenage parents;Teenagers;telehealth;Testing;Time;Training;Transportation;United States;violence prevention;virtual;virtual assessment;virtual delivery;virtual health;virtual platform;Vulnerable Populations;Work

PROJECT_TITLE: Preventing Intimate Partner Violence Among Teens Who Are Pregnant or Parenting

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a devastating, progressive scarring disease of the lung that is driven by multiple mechanisms. Tissue stiffening and aberrant metabolism have been identified as critical pathways contributing to progression and I have now identified potential cross-talk between these two mechanisms. Using clinically relevant patient derived cell lines and animal models I will investigate the mechanism linking stiffness and metabolism, as well as test the efficacy of targeting mechanotransduction to reduce fibrosis development and limit metabolic changes.

PI_NAMEs: THOMAS FREEBERG, MARGARET  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Animal Model;Architecture;Area;Attenuated;Bleomycin;career;Cell Culture Techniques;cell growth regulation;Cell Line;Cell surface;Cells;Cessation of life;Chemicals;Cicatrix;clinically relevant;Communication;Critical Pathways;crosslink;Data;Data Analyses;Development;Disease;Educational process of instructing;Effectiveness;efficacy testing;Elasticity;Energy Metabolism Pathway;Environment;Enzymes;Exhalation;experience;experimental study;Extracellular Matrix;Faculty;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Foundational Skills;Gases;Genetic;Goals;Grant;Human;idiopathic pulmonary fibrosis;in vivo;Individual;inhibitor;innovation;insight;K-Series Research Career Programs;knock-down;Knockout Mice;Knowledge;Link;loss of function;Lung;Lung Diseases;Mechanics;Mechanoreceptors;mechanotransduction;Mentors;Metabolic;Metabolism;metabolomics;mouse model;Mus;new therapeutic target;nintedanib;novel;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Physical condensation;Physiological;Piezo 2 ion channel;Pirfenidone;Positioning Attribute;pre-clinical;Production;Productivity;Prognosis;Proteins;Publishing;Pulmonary Fibrosis;receptor;Reporting;Research;Research Personnel;Research Project Grants;response;Role;Sampling;Scientist;Signal Transduction;Stretching;Structure of parenchyma of lung;targeted treatment;tenure track;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissues;Training;training opportunity;Transforming Growth Factor beta;Translational Research;Universities;Virginia;Work;Writing

PROJECT_TITLE: Mechanotransduction regulation of cellular metabolism in pulmonary fibrosis


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative While numerous chemotherapies give rise to senescence, a type of cell arrest implicated in metastatic disease and therapy resistance, non-invasive methods to image senescence via associated antigens in tumors remain lacking. In this proposal, we will characterize in vitro and in vivo changes in antibody- based PET imaging agents in response to several senescence-inducing therapies in murine as well as human pancreatic cancer models; define pharmacological methods to minimize antigen shed; and identify new antigens in collaboration with the Lowe Lab and independently from available RNAseq databases. Overall, we will demonstrate the enhanced potency of targeted alpha therapy with chemotherapy-induced senescence and apply our newly developed multiplexed PET method for dual imaging of the therapeutic impact in immune populations.

PI_NAMEs: PRATT, EDWIN CHARLES (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Acceleration;Address;Aftercare;Antibodies;Antibody-drug conjugates;antigen binding;antigen detection;Antigens;bafilomycin A1;Biodistribution;Bioinformatics;Biological;Biological Assay;Biopsy;cancer cell;cancer imaging;cancer therapy;career development;cBioPortal;CD8B1 gene;cell type;Cells;Cessation of life;Chelating Agents;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Chlorpromazine;Circulation;clinically relevant;Collaborations;Combination Drug Therapy;cytokine;Cytostatics;Databases;Detection;Diagnosis;Disease;Dose;Endocytosis;Environment;established cell line;Exocytosis;Fibroblasts;gemcitabine;Human;Image;imaging agent;imaging approach;Immune;immune imaging;Immunologics;ImmunoPET;improved;In Vitro;in vivo;Inflammatory;inhibitor;insight;Interleukin-6;Isotopes;Label;Link;Lovastatin;Lysosomes;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;member;Membrane;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;Mus;neoantigens;Neoplasm Metastasis;neutrophil;non-invasive imaging;novel therapeutics;Oncogenes;Organoids;Paclitaxel;pancreatic cancer cells;pancreatic cancer model;pancreatic neoplasm;Patients;pharmacologic;Phase;Population;Positron-Emission Tomography;prevent;Radiation;Radiation therapy;Radionuclide therapy;radiotracer;reconstruction;Regimen;Research;Resistance;response;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;sex;Signal Transduction;small molecule;small molecule inhibitor;Source;Specificity;Surface Antigens;Survival Rate;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;theranostics;Therapeutic;therapeutic target;Therapeutically Targetable;Time;Tissues;tool;Tracer;transcriptome sequencing;tumor;Tumor Burden;tumor growth;tumor heterogeneity;tumor microenvironment;tumorigenesis;tumorigenic;Universities;uptake;Vascular Endothelial Growth Factors;Washington;Work

PROJECT_TITLE: Targeting Pancreatic Cancer Senescence with ImmunoPET

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]