ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Narrative: Texas Tech University Health Sciences Center is a leader in academic health and biomedical research training in a West Texas region that comprises half of the state’s land mass and 10% of the state’s population. Research drives innovation and discovery, changes the lives of those we serve, and attracts a talented workforce of faculty, staff and students. This is a capacity-building project that will grow research excellence at our university.

PI_NAMEs: MCMAHON, LANCE R. (contact)

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: Acceleration;access disparities;Achievement;Address;Administrator;Area;Biomedical Research;biomedical scientist;brain health;Cardiometabolic Disease;Categories;Clinical;Clinics and Hospitals;Communicable Diseases;Communication;Communities;community engaged research;Community Services;Country;County;Data;Data Reporting;Discipline of Nursing;Doctor of Philosophy;Economics;Effectiveness;Eligibility Determination;Ensure;Equipment;Evaluation;evidence base;Extramural Activities;Faculty;FAIR principles;Fiber;Food;Fostering;Funding;Future;Geographic Locations;Goals;Grant;Health;health care availability;health care quality;health care service;Health education;Health Occupations;Health Professional;Health Sciences;health training;Healthcare;Hispanic-serving Institution;Human Resources;Inequity;Information Technology;Infrastructure;innovation;instrument;Malignant Neoplasms;Medicine;meetings;metropolitan;Needs Assessment;next generation;operation;Patient Care;Performance;Personal Satisfaction;Persons;Pharmacy facility;Population;Population Growth;Process;Productivity;programs;Public Health;Qualifying;recruit;Reporter;Research;research in practice;Research Priority;Research Training;response;Risk;Risk Assessment;rural area;Rural Community;Rural Health;Schools;Scientist;Secure;Services;Structure;Students;Talents;Teacher Professional Development;Texas;tool;Translating;Translational Research;trend;United States;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: The Future of Rural Health: Accelerating Biomedical Excellence at TTUHSC


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rehabilitation;Social Determinants of Health

ORG_CITY: Atlanta

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAPHABIT, INC.

ORG_STATE: GA

PHR: The MapHabit System (MHS), our neuroscience-based, innovative assistive technology and interactive care management platform is focused on people living with Alzheimer’s disease and Alzheimer’s disease related dementias and helps organize an individual's habits and routines into visual maps i.e., step-by- step pictures/videos to successfully carry out activities of daily living (ADLs) and other activities. This CRP will boost commercialization and marketability of the MHS by implementing the goals of three interconnected Specific Aims (SAs) that will (SA1) strengthen our platform infrastructure and security to enable new predictive analytics components, (SA2) enhance user appeal and user “stickiness” by upgrading our innovative gamification programs and improvements related to the front-end user interface, and (SA3) enhance customer care processes utilizing social determinants of health (SDOH) Z codes. Taken together, these goals provide particularly important developments for successful commercialization because value-based care models to address health equity disparities are increasingly being linked to SDOH, and SDOH codes, and because these goals reflect the nation’s public health goal of further reducing the burden of AD/ADRD on individuals, their families and caregivers, and society at large.

PI_NAMEs: GOLDEN, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Architecture;Area;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Award;Behavioral;behavioral health;Brain region;Businesses;Calendar;care coordination;Caregiver Burden;caregiver education;Caregiver support;Caregivers;caregiving;Caring;Certification;Client;Clinic;Clinical;Code;cognitive change;cognitive disability;Collaborations;commercialization;Communication;Communities;Community Health;Consult;Consultations;Data;Data Set;decision-making capacity;Dementia;demographics;Development;Disparity;effective intervention;effective therapy;Electronics;experience;Family;Feedback;food insecurity;Future;generative artificial intelligence;Goals;Government;Habits;health determinants;health equity;health goals;Health Personnel;health plan;Health Resources;Impaired cognition;improved;Incentives;Individual;Infrastructure;innovation;Intake;Learning;Legal patent;Lewy Body Dementia;Link;loved ones;machine learning model;Managed Care;Maps;Marketing;Medicaid;Medical;Memory;Memory impairment;Modeling;Neurosciences;Participant;patient home care;Pattern;Personal Satisfaction;Persons;Phase;population health;Positioning Attribute;Predictive Analytics;Privatization;Process;programs;promoter;Public Health;Quality of life;Recommendation;recruit;Reporting;Resources;Rewards;Sampling;satisfaction;Schedule;Security;Self Care;Self-Help Devices;Signal Transduction;Small Business Innovation Research Grant;social;social health determinants;Social isolation;Societies;sociodemographics;Speed;success;System;Technology;technology platform;Telephone;Testing;Time;Training;Training Programs;United States National Center for Health Statistics;United States National Institutes of Health;Update;usability;virtual healthcare;vision science;visual map;Voice;waiver;Work

PROJECT_TITLE: Adding technology that will enhance commercialization of our neuroscience-based innovative assistive technology platform for living with Alzheimer's disease and Alzheimer's disease related dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cancer is driven by DNA mutations which can increasingly be used to determine the type, likely outcome and best treatment options for individual patients. Establishing the clinical relevance of each mutation requires experts to review and summarize a growing body of evidence. By coordinating the efforts of these disease experts we will build a database of mutations and information that helps doctors guide treatment of cancer patients.

PI_NAMEs: GRIFFITH, MALACHI  (contact);GRIFFITH, OBI L.

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Acceleration;Address;Adopted;American Society of Clinical Oncology;cancer diagnosis;Cancer Patient;cancer therapy;Case Study;Classification;Clinical;clinical translation;Clinical Trials;clinically actionable;clinically relevant;clinically significant;ClinVar;Communities;Community Clinical Oncology Program;Consumption;Data;data interoperability;data platform;data sharing;Databases;Dedications;Development;Diagnosis;Diagnostic;Disease;DNA Sequence Alteration;editorial;Ethics;experimental study;FAIR principles;Gene Fusion;Genes;genome resource;genomic data;genomic variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;Growth;Guidelines;Health;Heritability;Human;human disease;improved;individual patient;Information Resources;Infrastructure;interoperability;Knowledge;knowledge curation;Knowledge Extraction;knowledgebase;Leadership;Level of Evidence;Malignant Neoplasms;member;Modeling;Mutation;Natural Language Processing;neoplasm resource;Oncogenic;online resource;organizational structure;Outcome;Paper;Phenotype;pre-clinical;precision oncology;Prediction of Response to Therapy;Procedures;Process;Prognosis;prognostic;Protocols documentation;Publications;recruit;Research;Resources;Role;Science;Secure;Sister;Somatic Mutation;Source;Specific qualifier value;Stream;System;Technology;Text;Time;tool;treatment response;Variant;Work;working group

PROJECT_TITLE: Creation of a knowledgebase of high quality assertions of the clinical actionability of somatic variants in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)S]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Proteins containing disordered regions are implicated in devastating human diseases but are challenging to characterize by conventional methods. This research will apply a novel approach to determine the molecular mechanisms by which the structured and disordered regions of the tumor suppressor p53 function synergistically to activate it in response to cellular DNA damage. Activation of p53 is of central importance in the prevention of cancer.

PI_NAMEs: WRIGHT, PETER EDWIN (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Amino Acid Sequence;Biological Process;cancer prevention;Cardiovascular Diseases;Cells;Coupling;Cysteine;Diabetes Mellitus;Disease;DNA Damage;Engineering;Eukaryota;flexibility;fluorophore;genetic regulatory protein;Goals;Human;human disease;insight;intein;intermolecular interaction;Isotope Labeling;Length;Ligation;Malignant Neoplasms;Mediating;Methods;Molecular;Mutation;Neurodegenerative Disorders;non-Native;novel strategies;Play;Post-Translational Protein Processing;Protein Dynamics;Proteins;Proteome;Regulatory Pathway;Research;response;RNA Splicing;Role;Site;Spin Labels;Stress;structural biology;Structure;tool;TP53 gene;Tumor Suppressor Proteins

PROJECT_TITLE: Structural characterization of large eukaryotic proteins containing both folded and disordered domains

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Liver Disease;Radiation Oncology

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Colorectal cancer is one of the most common cancers in both men and women in the United States and accounts for approximately 140,000 new cases annually. Hepatic metastasis, the dominant feature of life- limiting disease, occurs in approximately 20–50% of patients with colorectal cancer. In this study, we propose developing a novel strategy (hyperthermia + ferroptotic agent + TRAIL) to treat colorectal liver metastases.

PI_NAMEs: LEE, YONG J (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: anti-cancer;Apoptosis;Applications Grants;artesunate;Biochemical;biological adaptation to stress;Biological Products;Blood;Cancer Etiology;Cardiovascular system;Cause of Death;Cell Death;Cells;Cessation of life;Chemoembolization;colon cancer patients;Colorectal;Colorectal Cancer;combinatorial;Combined Modality Therapy;cytotoxicity;Diagnosis;Disease;Dose Limiting;Drug Kinetics;Effectiveness;endoplasmic reticulum stress;Excision;Gene Expression Profile;genetic signature;Glomerular Filtration Rate;Goals;Grant;Half-Life;Hepatic;Hepatic Tissue;Human;Hyperthermia;hyperthermia treatment;improved;in vivo;Induction of Apoptosis;Injections;insight;interest;Intravenous Bolus;Isolated Hepatic Perfusion;Kidney;Life;Ligands;Liver;Malignant - descriptor;Malignant Neoplasms;Maximum Tolerated Dose;men;Metabolic Clearance Rate;Metastatic Neoplasm to the Liver;Mitochondria;Modeling;Molecular;multimodality;Neoplasm Metastasis;new therapeutic target;Normal Cell;novel;novel strategies;novel therapeutics;Oncologist;Operative Surgical Procedures;Outcome;Outcome Study;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Persons;Play;preclinical efficacy;preclinical study;Proteins;Radiation therapy;Radioembolization;Rattus;receptor;Receptor Gene;Regimen;Research Project Grants;Rest;Role;sensor;Serum;Signal Pathway;Sprague-Dawley Rats;subcutaneous;systemic toxicity;Techniques;Testing;Therapeutic;Thermal Ablation Therapy;TNF gene;TNFSF10 gene;Toxic effect;treatment strategy;tumor;tumor growth;Tumor Tissue;United States;Unresectable;Woman;Xenograft procedure

PROJECT_TITLE: Assessment of hyperthermia-based multimodal approach for hepatic colorectal metastases

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN JUAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE: OVERALL COBRE Center for the Promotion of Cancer Health Equity (CePCHE) The Center for the Promotion of Cancer Health Equity (CePCHE) will focus on Hispanic health equity in cancer using a comprehensive research - basic, translational, clinical – approach to build the University of Puerto Rico (UPR) capacity, expanding the pipeline of competitive Hispanic cancer researchers to address cancers that are disproportionately higher in Puerto Rico and among mainland US Hispanics.

PI_NAMEs: BAERGA-ORTIZ, ABEL J (contact);COLON, VIVIAN

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Accounting;Address;Advanced Malignant Neoplasm;anti-cancer research;Basic Science;Biochemistry;Bioinformatics;Biomedical Research;Biostatistics Core;Cancer Biology;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer type;Cause of Death;Centers of Research Excellence;Cessation of life;Clinical;Collaborations;Colon;Communities;community engagement;Community Outreach;Complement;Complex;Comprehensive Cancer Center;computerized data processing;data repository;design;Development;Disparity;disparity gap;early onset colorectal cancer;Evaluation;evidence base;experience;Faculty;fundamental research;Genetic;graduate student;Growth;health disparity;health equity;health equity promotion;Health equity research;Health Professional;Hispanic;Hispanic Populations;Human;implementation science;improved;Incidence;Infrastructure;Institution;Investments;Island;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Mentors;Methodology;Modeling;mortality;multidisciplinary;multiple omics;neighborhood disadvantage;oral HPV;outreach;Palliative Care;Peer Review;Pontine structure;Population;population based;Population Sciences;Positioning Attribute;Postdoctoral Fellow;prospective;psychosocial;Public Policy;Publications;Publishing;Puerto Rican;Puerto Rico;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Science;Secure;Services;socioeconomic disadvantage;Solid;Subgroup;Training;United States;United States National Institutes of Health;Universities;Woman


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: COLON, VIVIAN  (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Applications Grants;Award;Bioinformatics;Biostatistics Core;Cancer Center;cancer health disparity;Cancer health equity;cancer prevention;career development;Centers of Research Excellence;Colon;Communities;community engagement;Comprehensive Cancer Center;cost;Country;COVID-19 disparity;data repository;Dedications;Division of Cancer Control and Population Sciences;doctoral student;early-career faculty;Education and Outreach;Equity;Evaluation;experience;Faculty;Funding;Funding Opportunities;Future;Goals;health equity;innovation;Investments;Lead;Leadership;Malignant Neoplasms;Mentors;Monitor;outreach;Phase;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Process;Program Research Project Grants;programs;Puerto Rico;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Secure;Services;Structure;success;Teacher Professional Development;Training Programs;training project;undergraduate student;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LUGO-MARTINEZ, JOSE  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;analytical method;anti-cancer research;application programming interface;Area;Artificial Intelligence;Basic Science;Big Data;Bioinformatics;bioinformatics pipeline;Biological;Biomedical Research;Biometry;Biostatistics Core;Cancer health equity;Clinical Research;Collaborations;Collection;Communities;Complement;Computational Biology;computer infrastructure;computerized data processing;computerized tools;Data;Data Analyses;Data Collection;data management;data quality;data repository;data resource;Data Science;data sharing;Databases;Development;Education;Evaluation;Experimental Designs;Faculty;Future;Generations;genomic data;Genomics;Goals;Grant;Health equity research;high throughput analysis;Hispanic;improved;information model;Information Services;Infrastructure;Institution;interest;Investments;Journals;Knowledge;learning strategy;Libraries;Machine Learning;machine learning prediction;Maintenance;Malignant Neoplasms;Manuscripts;Methodology;multiple datasets;next generation sequencing;novel;Outcome;Peer Review;Pilot Projects;Play;population based;Population Research;Predictive Analytics;Predictive Value;programs;Publications;Publishing;Puerto Rico;Reproducibility;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Role;Semantics;Services;Software Tools;Solid;Statistical Data Interpretation;syntax;System;Terminology;tool;Training;Training and Infrastructure;Translational Research;Universities

PROJECT_TITLE: Research Core


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Prostate cancer causes death because the cancer cells move throughout the body, forming lethal metastasis. If prostate cell movement could be inhibited just as they begin to move, it would prevent them from spreading throughout the body. We have made a first-of-its-kind drug that stops these cells from moving, and in this proposal we would like to test whether it will stop their initial movement and thereby prevent development of deadly spread.

PI_NAMEs: BERGAN, RAYMOND C. (contact);NATARAJAN, AMARNATH (AMAR)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: 3-Dimensional;Achievement;Actin-Binding Protein;Address;Adhesions;Affect;Affinity;Animals;Autopsy;Binding;Binding Sites;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;Biophysics;Blood;bone;Calorimetry;cancer cell;cancer invasiveness;cancer prevention;cancer type;Canis familiaris;Carcinoma in Situ;Cause of Death;CDC37 gene;cell motility;Cell Physiology;cell type;Cells;chemoproteomics;Chromans;Clinical;clinically relevant;Complex;Coupled;Data;Development;Disease;efficacy evaluation;Engineering;Heat-Shock Proteins 90;Human;human disease;human model;Image;in silico;In Situ;In Situ Lesion;In Vitro;Individual;inhibitor;innovation;Intercept;Intervention;Invaded;Journals;kinase inhibitor;Knowledge;L-Plastin;LCP1 gene;luminescence;Malignant neoplasm of prostate;Malignant Neoplasms;mass spectrometer;Mediating;member;Metastatic Prostate Cancer;Modeling;Molecular;monomer;Motility;Movement;Mus;Nature;Neoplasm Metastasis;novel;Organoids;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;predictive modeling;prevent;Prevention;programs;Prostate;prostate cancer cell;Protac;Proteins;Proteome;Proteomics;Proto-Oncogenes;Rattus;Regulation;Regulatory Pathway;Research Personnel;Risk;Role;Safety;Signal Pathway;Signal Transduction;Specificity;System;Testing;Therapeutic;Tissues;Titrations;tool;Toxicokinetics;TP53 gene;Transgenic Model;Treatment Efficacy

PROJECT_TITLE: Preventing invasive prostate cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Active perceptual processes such as attention and saccadic eye movements are essential for sensory guided behavior and memory formation; however, the cortical circuit mechanisms of active sensory information processing remain poorly understood. The breakdown of active perceptual processes is debilitating and can be observed in various neuropathologies such as attention-deficit disorder, autism, schizophrenia, and in patients with Traumatic Brain Injury (TBI). In this proposal, we will use advanced statistical analyses, in combination with sophisticated computational modeling, of dense neurophysiological data from a non-human primate model of active perception to investigate circuit level principles of information processing in the brain.

PI_NAMEs: JADI, MONIKA P. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Animals;area V4;Arousal;Attention;Attention Deficit Disorder;autism spectrum disorder;awake;Bayesian Network;Behavior;Behavioral;Brain;Carrying Capacities;Categories;Cells;Code;Cognitive;computational neuroscience;Computer Models;Cues;Data;density;Dependence;Dimensions;Drowsiness;extrastriate visual cortex;flexibility;Frequencies;Functional dependence;information processing;interdisciplinary approach;Investigation;Joints;Mediating;Memory;Modeling;motor behavior;Nature;neural;neural correlate;Neurons;neuropathology;neurophysiology;nonhuman primate;novel;oculomotor;Organism;Output;Perception;Performance;Population;Process;Saccades;Sampling;Schizophrenia;selective attention;Sensory;Shapes;Source;Statistical Data Interpretation;Structure;System;TBI Patients;Techniques;Testing;Time;Vision;Visual Cortex;Work

PROJECT_TITLE: Discovering brain state dependent dynamics in large scale perceptual ensembles.

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DE

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Despite improvements in overall access to dental care for children in the U.S., oral health disparities persist, with low-income, publicly insured children bearing a disproportionate burden of dental disease. This study will contribute to the scientific knowledge about the potential spillover effects of adult-targeted Medicaid dental coverage policies on children. This evidence will be instrumental in informing policy and programmatic interventions aimed to improve dental care use among Medicaid-enrolled children and reduce oral health disparities.

PI_NAMEs: REYNOLDS, JULIE  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Accident and Emergency department;Adult;Age;Awareness;Behavior;care seeking;care systems;Caring;Child;Data;Dental;Dental Care;Dental Care for Children;Dental Health Services;Dental Offices;Development;Disparity;Emergency department visit;Emergency Situation;Enrollment;Future;Goals;Health;health disparity;Health Services Accessibility;Health Services Research;Improve Access;improved;Insurance;Interruption;Intervention;Knowledge;Low income;lower income families;Measures;Medicaid;National Institute of Dental and Craniofacial Research;Natural experiment;Oral health;Outcome;Parents;Policies;Preventive;Preventive care;Privatization;Quasi-experiment;Research;Research Design;Resources;secondary analysis;Series;sound;Testing;Time;Tooth Diseases;trend;United States;Work

PROJECT_TITLE: Longitudinal Examination of Changes in Medicaid Adult Dental Coverage and Spillover Effects on Children


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PI_NAMEs: SOTO-SALGADO, MARIEVELISSE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;barrier to care;cancer care;Cancer Control;cancer diagnosis;Cancer Etiology;Cancer health equity;cancer invasiveness;Cancer Patient;cancer therapy;care providers;career;Caring;Cervical;Cervical Cancer Screening;chronic infection;Clinic;clinical care;Colon;Colposcopy;Communities;Consensus;Continuity of Patient Care;Data;Development;Diagnosis;Discrimination;Disparity;Enrollment;Ensure;Equity;Ethnic Population;Evaluation;Evidence based intervention;experience;Focus Groups;follow-up;Funding;General Population;Goals;Health;health care availability;health disparities in women;health equity;Health Personnel;Health Services Accessibility;Healthcare;high risk;Hispanic Women;HIV;HIV/AIDS;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papillomavirus;improved;Incidence;informant;insurance claims;Insurance Coverage;Intervention;Interview;Investigation;Lesion;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Medical Staff;Methods;Monitor;Morbidity - disease rate;mortality;neoplasm registry;Oncogenic;Oncology;optimal treatments;Outcome;Pap smear;Persons;Population;premalignant;Prevalence;Prevention approach;Principal Investigator;Privatization;programs;Public Health;Puerto Rican;Puerto Rico;racial population;Recording of previous events;Recurrence;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Risk;screening;social;social health determinants;social stigma;Surveillance Program;Survival Analysis;Time;Training;treatment comparison;United States;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: Social determinants of health associated to the cervical cancer-related care across the cancer control continuum among women living with HIV in Puerto Rico


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Through this F30 training fellowship, I propose to examine the association between adiposity and ovulatory dysfunction among Samoan women. Project findings will shed light on the dual burden of cardiometabolic and reproductive risk among Pacific Islanders, who despite having among the highest obesity prevalence globally, are underrepresented in epidemiologic research. This training proposal integrates new learning experiences in longitudinal data analysis, epidemiological study design and implementation, and reproductive endocrinology which will prepare me for a career as a physician scientist that conducts longitudinal epidemiological research to characterize how obesity affects maternal and child health outcomes in low-resource settings.

PI_NAMEs: OYAMA, SAKURAKO  (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Abdomen;access disparities;Address;Affect;aged;Amenorrhea;Anovulation;assisted reproduction;Biochemical;Biometry;Body fat;Body mass index;Cardiometabolic Disease;cardiometabolism;career;Clinical;cohort;cost;Country;Data;Data Analyses;Data Collection;Diabetes Mellitus;Diagnosis;emotional distress;epidemiology study;Evaluation;experience;Family;Fellowship;Female;Functional disorder;Goals;Growth;Health;high body mass index;Hip region structure;hormonal contraception;Human;Hypertension;Income;Infertility;infertility treatment;insight;Irregular Menstruation;Learning;Length;Longitudinal cohort study;low and middle-income countries;Luteinizing Hormone;Maternal and Child Health;Measures;men;Menstrual cycle;Menstruation;Mental Health;Mentors;Modeling;Morbidity - disease rate;mortality;Nutritional;Obesity;Oligomenorrhea;Outcome;Ovarian;ovarian dysfunction;Overweight;Ovulation;Pacific Islander;Pacific Islands;Patient Self-Report;Periodicity;Personal Satisfaction;Physicians;Polynesian;Prevalence;Procedures;Progesterone;prospective;protocol development;Proxy;Public Health;recruit;reproductive;Reproductive Endocrinology;Reproductive Health;Research;Research Design;Resource-limited setting;Resources;Risk;Risk Factors;Samoa;Samoan;Scientist;secondary infertility;skills;Specimen;Surveys;Text Messaging;Training;Ultrasonography;United States;urinary;Urine;Vagina;Variant;Woman

PROJECT_TITLE: Ovarian Function Among Samoan Women with Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  The insoluble tau aggregates present in multiple neurological disorders such as Alzheimer’s disease are morphologically and molecularly heterogeneous species that emerge from the assembly of tau seeds carrying specific molecular profiles. I aim to illustrate that tau’s molecular modifications in the form of its degree and pattern of hyperphosphorylation vary within tau oligomers and morphologically distinct insoluble tau aggregates in Alzheimer’s. These studies will facilitate the development of therapies that can accurately target various tau aggregates through the identification of the specific molecular signatures of tau seeds and tau aggregates present in human pathology.

PI_NAMEs: SANTIAGO-RUIZ, ADRIANA NAOMI (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Antibodies;Autopsy;Brain region;brain tissue;classification algorithm;Clinical;Color;combinatorial;corticobasal degeneration;Cytosol;Data;Dementia;Disease;Evaluation;Frequencies;Goals;Heterogeneity;Human;Human Pathology;human tissue;Huntington gene;hyperphosphorylated tau;Immunofluorescence Immunologic;innovation;Knowledge;Label;light microscopy;Link;Machine Learning;MAPT gene;Methodology;Microtubules;Modeling;Modification;Molecular;Molecular Profiling;monomer;Morphology;Nerve Degeneration;Nervous System Disorder;Neurofibrillary Tangles;Neurons;neuropathology;Patients;Pattern;Phosphorylation;Pick Disease of the Brain;Play;Post-Translational Protein Processing;Proteins;Research;Role;Severities;Shapes;Site;superresolution imaging;superresolution microscopy;Symptoms;tau aggregation;tau function;tau Proteins;Tauopathies;Testing;therapy development;Tissue Sample;Tissues;tool

PROJECT_TITLE: Super-Resolution Imaging of Alzheimer's Disease Hyperphosphorylated Tau Aggregates


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Pain Research;Palliative Care

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC RELEVANCE (Project Narrative)  The outcome of this novel study will be to advance science by providing new evidence, in a US population, of the efficacy of a trial of acupuncture for the treatment of symptomatic stable angina. This study also has the potential to improve patient care and patient outcomes since our results may suggest that acupuncture is efficacious as a complementary therapy for women and men with stable angina thus improving symptom management.

PI_NAMEs: DEVON, HOLLI A (contact);SCHLAEGER, JUDITH MICHELLE

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Academic Medical Centers;Acupuncture Points;Acupuncture Therapy;Address;Adult;American;American Heart Association;Analgesics;Area;Arrhythmia;associated symptom;Atrial Fibrillation;attentional control;Autonomic nervous system;Black Populations;blood pressure reduction;Blood Vessels;Brain Stem;Cardiac;Cardiology;Cardiovascular system;care outcomes;Charge;Chest Pain;Chinese;Chinese Traditional Medicine;Clinic;Complementary therapies;Control Groups;Coronary;Data;Diagnosis;Dimensions;disability;Disease;efficacy evaluation;efficacy testing;Elements;Emotional Stress;Enrollment;Exercise;Exertion;experience;experimental group;Frequencies;functional status;Goals;group intervention;Guidelines;Health;health assessment;health care service utilization;health inequalities;health related quality of life;health service use;Healthcare;Heart Arrest;Heart Diseases;Heart failure;Heart Rate;Hospitalization;Hospitals;Hour;Hyperalgesia;Immune;impaired functional status;improved;Infarction;Inflammatory;innovation;Integrative Therapy;Ischemia;Location;McGill Pain Scale;Measures;Mediating;Medical;men;Menopausal Status;Minority Groups;Modeling;mortality;Myocardial Infarction;Myocardial Ischemia;neural;novel;Obstruction;Outcome;Outcome Measure;Pain;Pain intensity;Pain Measurement;pain reduction;pain symptom;Participant;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Persistent pain;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Pilot Projects;Placebo Effect;Population;Prevalence;primary outcome;Process;Prospective Studies;Protocols documentation;Psyche structure;Qualifying;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Science;secondary outcome;Severities;sex;social disparities;Standardization;Statistical Methods;symptom management;symptom treatment;symptomatic improvement;Symptoms;Syndrome;Testing;treatment effect;treatment group;Treatment Protocols;United States;video session;Woman;Work

PROJECT_TITLE: Effects of Acupuncture on Symptoms of Stable Angina: A Randomized Controlled Trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Burden of Illness;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GONZALEZ-PONS, MARIA  (contact)

PROJECT_TERMS: Address;Age;biobank;Blood;Cancer Burden;Cancer Etiology;cancer health disparity;Cancer health equity;cancer subtypes;carcinogenicity;Caribbean region;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;cohort;Colon;colon carcinogenesis;Colorectal Cancer;colorectal cancer registry;colorectal cancer risk;Complement;Cuban;Data;Death Rate;Development;Disparity;early onset;early onset colorectal cancer;Eating;epidemiologic data;Epidemiologic Factors;Epidemiological trend;Epidemiology;ethnic health disparity;Ethnic Population;Etiology;Event;exome sequencing;familial colorectal cancer;Feces;Foundations;Freezing;Future;Generations;Genes;Genetic;genetic analysis;genetic variant;Genetic Variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;Hispanic;Hispanic Populations;Incidence;Individual;insight;Knowledge;Malignant Neoplasms;men;Molecular;Molecular Epidemiology;mortality;Mucous Membrane;National Cancer Program;neoplasm registry;Normal tissue morphology;novel;Organoids;Participant;Pathogenicity;Pathway interactions;Patients;Population;Population Heterogeneity;Positioning Attribute;Predisposing Factor;Prevention strategy;Principal Investigator;Process;Prognosis;programs;prospective;Public Health;Puerto Rican;Puerto Rico;racial health disparity;racial population;recruit;Reporting;Research;Risk Factors;risk stratification;Sampling;SEER Program;skills;sociodemographics;Subgroup;survival disparity;Survival Rate;Time;treatment strategy;trend;tumor;Tumor Tissue;Variant;Woman

PROJECT_TITLE: Epidemiologic and germline genomic characterization of early-onset colorectal cancer among Hispanics


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The Native Mass Spectrometry Guided Structural Biology Center will develop and disseminate advanced scientific instrumentation and computational tools for the characterization of biomedically-important protein and nucleoprotein complexes. Close collaboration with biomedical researchers will improve the understanding, prevention, and treatment of various diseases and conditions such as HIV, viral infections, and neurological disorders.

PI_NAMEs: WYSOCKI, VICKI H. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Agreement;Antibodies;Architecture;Area;Automobile Driving;Binding;Biomedical Technology;Blood capillaries;Buffers;Capillary Electrophoresis;Charge;Collaborations;Communication;Communities;community engagement;Complement;Complex;complex data;Computer Models;computerized tools;Computing Methodologies;Coupled;Couples;Coupling;Data;design;Detection;Development;Devices;digital;Disease;Dissociation;Educational workshop;Electrospray Ionization;empowerment;flexibility;Fostering;Fourier Transform;Funding;Future;Genetic;Geography;Goals;Grant;Heterogeneity;HIV;Human Resources;improved;Industrialization;Institution;instrumentation;interest;ion mobility;Ions;Journals;Laboratories;Leadership;Legal patent;Licensing;Lipids;Macromolecular Complexes;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;member;Membrane Glycoproteins;Membrane Proteins;Membrane Structure and Function;Mission;Molecular Conformation;Multiprotein Complexes;Nervous System Disorder;non-Native;Nucleoproteins;organizational structure;Phase;Photometry;Polymorph;Prevention;Procedures;Productivity;protein complex;protein oligomer;Protein Secretion;Proteins;Proteomics;Publications;Quaternary Protein Structure;Research Personnel;Resolution;Resources;restraint;RNA;Role;Sampling;Scientific Advances and Accomplishments;Services;Site;Small Business Innovation Research Grant;Specialist;Spectrometry;stoichiometry;structural biology;Structure;Sudden infant death syndrome;Surface;System;tau aggregation;Technology;technology development;technology research and development;Technology Transfer;Temperature;Thermodynamics;tool;Training;Translating;Translations;Vendor;Viral;virtual;Virus Diseases;Water;Work


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Burden of Illness;Cancer;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Social Determinants of Health

PI_NAMEs: ORTIZ, KAREN J (contact)

PROJECT_TERMS: Advance Care Planning;Advanced Malignant Neoplasm;Affect;Aging;aging population;Attitude;Behavior;Breast;Cancer Burden;cancer care;Cancer Center Planning Grant;Cancer health equity;Cancer Patient;care costs;Caregivers;Caring;Cause of Death;Characteristics;Clinical;Communication;Complex;Consultations;cost;cost comparison;cost effective;Coupled;Cross-Sectional Studies;Data;Data Analytics;Data Collection;Databases;Decision Making;Development;Diagnosis;Disparity;Disparity population;Economic Burden;effective intervention;Emergency department visit;end of life;end of life care;Enrollment;Family;Future;gastrointestinal;Goals;Gynecologic;health care delivery;Health Insurance;Healthcare Systems;Hematologist;Hispanic;Hospice Care;hospice environment;hospice utilization;Hospitalization;improved;Incidence;Inequity;Inpatients;Insurance;Insurance Coverage;Intervention;Investigation;Knowledge;leukemia;Life;Low income;Lung;male;malignant mouth neoplasm;Malignant Neoplasms;medical specialist;mortality;neoplasm registry;Oncologist;opioid use;Outcome;Pain management;Palliative Care;Palliative Medicine;participant enrollment;Patient Care;Patients;Pattern;Persons;Phase;Physicians;Population;Poverty;preference;Privatization;Procedures;Process;Prognosis;Prostate;Provider;Puerto Rican;Puerto Rico;Quality of Care;Quality of life;randomized trial;Recommendation;Series;sociodemographics;Surveys;System;Testing;Time;Training;United States;Variant

PROJECT_TITLE: Examining the multilevel factors on quality of end-of-life care among cancer patients in Puerto Rico


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Social Determinants of Health

PI_NAMEs: PEREZ-SANTIAGO, JOSUE  (contact)

PROJECT_TERMS: 21 year old;Acquired Immunodeficiency Syndrome;Affect;Age;Aging;antiretroviral therapy;bead chip;Behavioral;biobank;Bioinformatics;Biological;Biological Aging;Biological Assay;Biological Process;Biometry;Blood;Butyrates;Cancer Biology;Cancer health equity;cancer prevention;cancer risk;carcinogenesis;Cell Aging;Characteristics;Chronic;Collection;community organizations;Data;Data Storage and Retrieval;Development;Diagnostic;Disparity;DNA Damage;DNA Methylation;dysbiosis;Early identification;Enrollment;Epidemiology;experience;Genome;genomic locus;Genotype;Goals;health disparity;high risk population;HIV;HIV Infections;HPV oropharyngeal cancer;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune response;Immunologic Factors;immunosenescence;Immunosuppression;improved;Incidence;Infection;Inflammation;Integration Host Factors;Interdisciplinary Study;Knowledge;lifestyle factors;Longitudinal Studies;machine learning classifier;Malignant Neoplasms;men;Mentors;Methylation;methylation pattern;methylome;microbial;microbiome;Mucosal Immune Responses;Mucosal Immunity;multiple omics;Natural History;novel;Oral;Oral cavity;Oral Characters;Oral health;oral HPV;oral HPV infection;oral microbial community;oral microbiome;Outcome;outreach;Oxidative Stress;Pathogenicity;Patient Recruitments;Persons;Predictive Factor;Prevalence;prevent;Prevention;Preventive;prognostic;public education;Public Health;Puerto Rico;Resources;Ribosomal DNA;Risk;Risk Factors;Risk Reduction;Saliva;screening guidelines;Shapes;Social Behavior;social determinants;social health determinants;socioeconomic disadvantage;socioeconomics;Spectrophotometry;Time;Tissues;tumor progression;tumorigenesis;Viral;Virus Integration;Visit;Volatile Fatty Acids;Woman;Work

PROJECT_TITLE: Multi-Omics Predictors of Oral HPV Outcomes among PLWH


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric;Precision Medicine;Prevention;Sleep Research

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Obstructive sleep apnea (OSA) in children is a common problem that is usually treated by adenotonsillectomy (AT), but the optimal treatment for children with small tonsils is unclear. This randomized controlled trial of sleep endoscopy-directed surgery vs AT in children with small tonsils will demonstrate the effectiveness of a personalized surgical approach for the treatment of OSA in children. This study has the potential to change the treatment paradigm in children from a one-size-fits-most approach to one of personalized treatment with improved surgical outcomes and less need for secondary treatments.

PI_NAMEs: LAM, DEREK J (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Address;Adult;Age;airway obstruction;Anatomy;Apnea;Attention deficit hyperactivity disorder;Autonomic Dysfunction;Case Series;Characteristics;Child;Childhood;Clinic;Clinical;comparative effectiveness trial;comparison control;Confusion;Data;Decision Making;Disease;effective therapy;Effectiveness;effectiveness testing;Endoscopes;Endoscopy;Event;executive function;flexibility;Funding;health care service utilization;High Prevalence;Hypertension;Hypertrophy;improved;improved outcome;improvement on sleep;indexing;individualized medicine;Intervention;Knowledge;Larynx;nasal obstruction;Neurocognitive Deficit;Nose;novel;novel strategies;Obesity;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;optimal treatments;Outcome;Palate;Patients;Pattern;Performance;personalized approach;personalized medicine;Pharmaceutical Preparations;Pharyngeal structure;Physiological;precision drugs;Prevalence;Principal Investigator;Procedures;Publishing;Quality of life;Randomized, Controlled Trials;Recommendation;Reporting;Research;response;Risk Factors;Schools;Sedation procedure;Severities;Site;Sleep;standard care;study population;surgery outcome;Symptoms;Testing;tongue root;Tonsil

PROJECT_TITLE: A Personalized Surgical Approach for the Treatment of Children with Obstructive Sleep Apnea and Small Tonsils


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Acanthamoeba keratitis is a blinding eye infection with poor treatment options. This study will determine whether steroid eye drops improve vision outcomes and also assess for genetic predictors of severe inflammation using metagenomic sequencing. The study will help ophthalmologists better treat this debilitating eye infection.

PI_NAMEs: KEENAN, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Acanthamoeba;Acanthamoeba Keratitis;Adrenal Cortex Hormones;Advocate;Affect;Amoeba genus;anterior chamber;Anti-Inflammatory Agents;Bacteria;Biological;Brazil;Clinical;clinical practice;clinical predictors;Clinical Research;Collaborations;Contact Lenses;Cornea;corneal scar;Cyst;Data;deep sequencing;Development;Diagnosis;Disease Outbreaks;Eligibility Determination;endosymbiont;Enrollment;Equipoise;evidence base;Eye;Eye Infections;Eyedrops;Fright;Gene Expression;Gene Expression Profile;Genes;genetic information;genetic predictors;Growth;Image;Immunologic Factors;improved;In Vitro;India;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integration Host Factors;Interleukin Gene;Intervention Trial;Keratoplasty;Knowledge;Masks;metagenomic sequencing;Metagenomics;Natural Immunity;Observational Study;ocular pain;Ophthalmologist;Organism;Outcome;Pain;Participant;pathogen;Pathway interactions;Patients;Perforation;Pharmaceutical Preparations;Placebos;polyhexamethylene biguanide;Polymerase Chain Reaction;prednisolone;primary outcome;Process;Prospective cohort;Prospective Studies;Provider;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recurrence;Regimen;Research Design;Research Personnel;Resolution;response;Risk;Risk Factors;Safety;Sample Size;Scleritis;secondary analysis;secondary outcome;sodium phosphate;Specialist;Specific qualifier value;standard of care;Steroid therapy;Steroids;Swab;Techniques;Therapeutic;Thinness;Time;TLR4 gene;TLR8 gene;topical antiseptic;Topical Corticosteroids;transcriptome;treatment trial;trial design;Ulcer;United Kingdom;United States;Virulence Factors;Vision;Visual;Visual Acuity;Work

PROJECT_TITLE: Parasitic Ulcer Treatment Trial


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: A significant portion of individuals with upper limb impairments are military service members or Veterans. In a survey of 347 people with tetraplegia, regaining arm and hand function was chosen most important for improving their quality of life. The VA’s commitment to early investment in innovation can improve the quality of life of Veterans with upper limb impairment and pave the way for more ubiquitous use of ARMs in the military, Veteran, and civilian population. The VA has also recognized the importance of caregiver input through their Campaign for Inclusive Care. Since most military caregivers are family members, it is even more important for technology to optimize their caregiver role. A collaborative flexible ARM shared control system that allows the Veteran to dictate how its usage best meets their changing needs will increase Veteran’s ability to engage in self-care, allow for greater participation in the community, and allow for those who care for Veterans with disabilities to spend more time in the role of family member, further positively impacting quality of life.

PI_NAMEs: STYLER, BREELYN  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Agreement;algorithm development;Amyotrophic Lateral Sclerosis;arm;arm function;arm movement;assistive robot;authority;Automobile Driving;Awareness;Back;Behavior;Benchmarking;career;Caregiver support;Caregivers;Caring;Clinical;Cognitive;cognitive ability;Communities;Complex;Computer software;Decision Making;design;Development;Diagnosis;disability;drinking;empowerment;Environment;Evaluation;Event;experience;Family;Family Caregiver;Family member;Feedback;Fill-It;flexibility;Future;Goals;Hand;Hand functions;Home environment;human subject;human-robot interaction;Impairment;improved;indexing;Individual;Industry;innovation;Interruption;Intuition;Investments;iterative design;Joystick;K-Series Research Career Programs;Left;Literature;Manuals;Measures;Methodology;microwave electromagnetic radiation;Military Personnel;military service;Modeling;Modification;Monitor;Movement;Multiple Sclerosis;Nature;operation;Performance;Persons;Phase;Population;Positioning Attribute;Powered wheelchair;predictive modeling;preference;Preparation;Principal Investigator;Process;Psyche structure;Quadriplegia;Quality of life;recruit;Reporting;Research Design;Robot;robot assistance;robot control;robot rehabilitation;robotic device;Robotics;Role;Rotation;Self Care;Self-Help Devices;service member;smart home;success;Surveys;System;Techniques;Technology;technology platform;Time;tool;Training;United States National Aeronautics and Space Administration;Upper Extremity;usability;Veterans;Vision;Voice;Water;Wheelchair user;Wheelchairs;Work;Workload;Wrist

PROJECT_TITLE: Flexible Control Authority With a Robotic Arm: Facilitating Seamless Transitions Between User and Robot Control in Multi-Action Manipulation Tasks.

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The long-standing goal of the University of Chicago MD/PhD training program in Growth, Development and Disabilities is to train outstanding physician-scientists. Formal training is provided for each degree, supplemented with ample, dedicated mentoring and advising to assure the attainment of this goal. The participants’ progress is followed throughout their time in the training program and their subsequent career trajectories.

PI_NAMEs: SCHWARTZ, NANCY B (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Grant;Institution;National Research Service Awards;Parents;Research Training

PROJECT_TITLE: Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This research proposal addresses system- and patient-level barriers in accruing to oncology therapeutic trials. The major goals of this project are to develop a clinical trial toolkit to minimize inefficiencies and streamline operations, and to focus on how best to scale research across other sites within our health system, with particular regard to engaging the research team and prospective patients. Protected effort for the duration of the award will provide Dr. Wagner-Johnston the necessary time to develop and implement the metrics, spend time at the satellite sites, and meet regularly with all of the stakeholders involved in these endeavors.

PI_NAMEs: WAGNER-JOHNSTON, NINA DELANEY (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Academic Medical Centers;Address;Attention;Award;Cancer Center;Caring;Clinical Research;clinical trial enrollment;Clinical Trials;Community Health;Comprehensive Cancer Center;Consent;COVID-19 impact;Development;diversity and inclusion;Electronic Mail;Enrollment;Ensure;feasibility trial;Goals;Health Educators;Health system;Hematologic Neoplasms;Home;improved;Incentives;Knowledge;Lead;Leadership;Learning;Lymphoma;meetings;Newsletter;novel strategies;Oncology;operation;Operations Research;outreach;Participant;patient-level barriers;Patients;Performance;Physicians;Precision medicine trial;programs;prospective;Research;Research Proposals;research study;Resources;Site;System;Therapeutic Trials;Time;tool;Update;web site;Work

PROJECT_TITLE: Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint


NIH_SPENDING_CATS: Aging;Cancer

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The overarching goal of this application is to understand the p53 tumor suppression network for the purpose of improving human disease diagnosis and treatment. The proposed researches will provide new insights into the biological function and regulatory mechanism of p53 in anti-tumor and anti-aging processes. The study will facilitate our knowledge of the fundamental regulatory mechanisms for p53, and will potentially lead to the development of therapeutic strategies for the treatment of human diseases.

PI_NAMEs: MARZLUFF, WILLIAM F. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: aging process;anti aging;Apoptosis;Autophagocytosis;BCL2 gene;BCL2L1 gene;Binding;Biochemical;Biological;Biological Process;Body fat;Cell Cycle Regulation;Cell Line;Cell Nucleus;Chiroptera;comparative;CUL9 gene;Cullin Proteins;Cytoplasm;Development;disease diagnosis;Dissection;DNA Sequence Alteration;Enzymes;Event;experimental study;extend lifespan;Genes;Genetic;Genetic Transcription;genome sequencing;Genomics;Glycolysis;Glycolysis Inhibition;Goals;human disease;improved;In Vitro;in vivo;Incidence;Induction of Apoptosis;inhibition of autophagy;insight;Knowledge;Lactate Dehydrogenase;Link;lipid biosynthesis;lipid metabolism;Lipids;Longevity;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Mus;mutant;Mutant Strains Mice;Nuclear;Nuclear Export;Nuclear Import;Nuclear Localization Signal;oxidation;Oxidative Phosphorylation;Peptide Signal Sequences;Physiological;Play;Polyubiquitination;Process;Proteins;Regulation;Research;Role;System;Testing;therapeutic development;TP53 gene;trait;transcription factor;Travel;treatment strategy;tumor;Tumor Suppression;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Function and regulation of cytoplasmic p53

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Dissemination and Implementation Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA  NATIONAL  HOSPITAL

PHR: PROJECT NARRATIVE In Kenya, like many other resource-limited settings, the burden of perinatal mood and anxiety disorders (PMAD) is high but routine screening and treatment is lacking. We have identified three evidence-based interventions to promote perinatal mental health: (1) universal mental health screening, (2) the Problem Management Plus (PM+) counseling intervention for women experiencing PMAD, and (3) telepsychiatry for women with severe symptoms or no response to PM+. We propose to combine these interventions in a stepped care model, named the Integrated Perinatal Mental Health program, develop implementation strategies to support its integration into routine PMTCT care in Kenya, and evaluate effectiveness and implementation outcomes of the package in a Hybrid Type II cluster-randomized trial in 20 healthcare facilities in Western Kenya, the region with the highest HIV prevalence in the country.

PI_NAMEs: BHAT, AMRITHA SUBRAY;KINUTHIA, JOHN  (contact);RONEN, KESHET

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adoption;adverse pregnancy outcome;Affect;antenatal;Anxiety;Anxiety Disorders;anxiety symptoms;arm;care delivery;care outcomes;Caring;Client;Cluster randomized trial;Consolidated Framework for Implementation Research;cost;Counseling;Country;Data;depressive symptoms;design;Development;disability;Educational workshop;effectiveness evaluation;effectiveness outcome;Ensure;Equity;Evidence based intervention;experience;Facility Controls;Feedback;Fetal Growth Retardation;Focus Groups;Generalized Anxiety Disorder;Health;Health care facility;Health Personnel;HIV;hybrid type 2 trial;Hybrids;implementation barriers;implementation outcomes;implementation strategy;improved;Infant;informant;Intervention;intervention delivery;intervention program;Interview;Kenya;Learning;low and middle-income countries;Low Birth Weight Infant;meetings;Mental Depression;Mental Health;mental health policy;Mental Health Services;Methods;Modeling;Mood Disorders;Mother-to-child HIV transmission;multidisciplinary;Names;Outcome;Patients;Penetration;Perinatal;Perinatal Care;perinatal mental health;perinatal women;Policy Maker;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy loss;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Prevalence;Prevention;Primary Care;primary care setting;primary outcome;Proctor framework;Program Effectiveness;programs;Provider;Quality of life;Questionnaires;Randomized;Recommendation;Resource-limited setting;response;Risk;routine care;routine screening;screening;secondary outcome;service delivery;Services;skills;social stigma;Specialist;standard of care;stillbirth;Structure;success;Supervision;Surveys;Symptoms;Technology;Teleconferences;telepsychiatry;Testing;therapy design;Training;Travel;treatment arm;treatment of anxiety disorders;Viral;Visit;Wait Time;Woman;World Health Organization

PROJECT_TITLE: Integration of stepped care for Perinatal Mood and Anxiety Disorders among Women Living with HIV in Kenya


NIH_SPENDING_CATS: Cancer;Hematology;Radiation Oncology

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This is a renewal application requesting continued funding for the Sylvester Comprehensive Cancer Center K12 Calabresi physician-scientist training program. The first group of graduating scholars are representative of successful recruitment and support, as all three have obtained extramural funding. The curriculum is evolving to better meet the needs of the scholars and for novel outreach to grow the pipeline of physician-scientist investigators from diverse backgrounds.

PI_NAMEs: POLLACK, ALAN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advocate;cancer health disparity;Cell Transplantation;Childhood;Clinical Management;Clinical Oncology;Clinical Oncology Supplement (K12);Clinical Sciences;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Critiques;design;Development;Doctor of Philosophy;Educational Curriculum;Faculty;Faculty Recruitment;Feedback;Fellowship;Florida;Foundations;Grant;Gynecologic Oncology;Head and neck structure;Hematology;inter-institutional;Joints;K-Series Research Career Programs;Link;Liquid substance;Malignant Neoplasms;Master of Science;Medical;Medical Oncologist;Medical Oncology;medical specialties;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Oncology;oncology program;Operative Surgical Procedures;Patients;Phase;Physicians;Population;Population Sciences;Process;programs;Radiation;Radiation Oncologist;Radiation Oncology;recruit;Research;Residencies;Resources;Running;Scholarship;Scientist;Solid Neoplasm;Standardization;Structure;Students;Surgical Oncology;Training;Translational Research;tumor;Universities;urologic;Urology

PROJECT_TITLE: UM Calabresi Clinical Oncology Research Career Development Award

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: FOREST GROVE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PACIFIC UNIVERSITY

PHR: Project Narrative Childhood adversity is a major risk factor for non-communicable diseases across the lifespan, and Kenya has a high rate of child maltreatment, a prominent form of childhood adversity. Despite the high prevalence rate, there is a lack of preventative services to support families to address child maltreatment and NCD burden in Kenya. This project will conduct an effectiveness study of the recently adapted evidence-based parenting program, SafeCare, for implementation in Kenya.

PI_NAMEs: ARMISTEAD, LISA P;NDETEI, DAVID MUSYIMI;SHANLEY, JENELLE R (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: abuse liability;Address;adolescent mental health;Adoption;Adult;Advisory Committees;Africa;AIDS prevention;Area;Behavioral;Biological;burden of illness;Cellular Phone;Cessation of life;Child;Child Abuse;Child Abuse and Neglect;Child Behavior;Child Development;Child Health;Child Rearing;Child Welfare;Childhood;childhood adversity;Childhood Injury;Chronic Disease;Clinical effectiveness;Communities;community building;community engagement;Community Health;Community Health Aides;cost effectiveness;Country;COVID-19;Disease;disorder risk;Distal;early life adversity;Effectiveness;effectiveness study;Equity;Evaluation;evidence base;Evidence based program;experience;Failure;Family;family support;field study;Foundations;Funding;Goals;Government;Health;health knowledge;High Prevalence;Home;Human Resources;Hybrids;implementation process;implementation research;improved;Infrastructure;Injury;Intervention;Kenya;Knowledge;Language;late life;Life;life span;low and middle-income countries;maltreatment;Manuals;medical attention;Mental disorders;Mental Health;Methods;Mission;Modality;Mothers;National Institute of Child Health and Human Development;Outcome;Parent-Child Relations;parenting intervention;Parents;Pathway interactions;Persons;physical conditioning;post intervention;prevent;Prevention approach;Prevention program;Preventive service;Primary Prevention;Probability;Problem behavior;programs;Provider;Public Health;Quality of life;Randomized;randomized trial;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource-limited setting;response;Risk;Risk Factors;Risk Reduction;Safety;scale up;Services;skills;Strategic Planning;Stress;success;Supervision;System;Testing;Training;Translating;treatment as usual;Universities;Violence;virtual;virtual delivery;volunteer;Work

PROJECT_TITLE: Implementing SafeCare Kenya to Reduce Noncommunicable Disease Burden: Building Community Health Workers' Capacity to Support Parents with Young Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(50)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

PHR: NARRATIVE Children of incarcerated parents are a particularly vulnerable population that are at risk for a host of negative outcomes, including increased likelihood of substance use in late childhood and adolescence. Mentoring is a commonly used positive youth development approach to prevention with this population, whose impact can be enhanced through identifying characteristics of effective mentors. Results from this project will help guide mentoring programs that serve vulnerable populations of youth to more accurately identify volunteers who may need additional training and support as mentors.

PI_NAMEs: STUMP, KATHRYN N (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Adolescence;Adult;Affective;Age;Alcohols;archived data;Attitude;Awareness;Behavioral;Black race;Caregivers;Caring;Characteristics;Child;Childhood;Cognition;Data;Data Set;Development;Drug Prescriptions;early adolescence;Effectiveness;efficacy evaluation;Empathy;Evaluation;experience;Exposure to;Face;Family;follow-up;Future;girls;Goals;Growth;High Prevalence;Hispanic;Imprisonment;improved;Intervention;knowledge base;Latinx;Length;Literature;Logistic Regressions;Marijuana;Measurement;Mentors;Mission;National Institute of Drug Abuse;Outcome;parent project;Parents;Personality Assessment;Personality Character;Personality Traits;Persons;Philadelphia;Population;Population Heterogeneity;Populations at Risk;positive youth development;Predictive Factor;premature;Prevention approach;Prevention program;programs;Randomized, Controlled Trials;Recording of previous events;reduced substance use;Regression Analysis;Reporting;Research;Risk;Role;Sampling;Screening procedure;Self Efficacy;Series;skills;Social Functioning;Stigmatization;Stress;substance misuse;substance use;success;Surveys;Survival Analysis;Symptoms;therapy development;Training;Trust;Victimization;volunteer;Vulnerable Populations;Work;Youth

PROJECT_TITLE: The impact of mentor characteristics on mitigating substance use outcomes among children of incarcerated caregivers

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The results of these experiments in animal models will provide critical new information about insula projection- specific mechanisms that can differentially drive compulsive alcohol drinking and alcohol-intake, and alcohol/anxiety co-morbidity, and especially whether there are sex differences in aINS mechanisms that drive these conditions. Alcohol Use Disorder is a substantial clinical and health problem, with AUD rates increasing in women in recent years, and anxiety likely contributes strongly. Thus, our experiments investigating the projection- and sex-specific mechanisms of excessive responding will help identify novel therapeutic targets for the treatment of human addiction and co-morbid anxiety, with broader relevance across neuropsychiatric conditions.

PI_NAMEs: HOPF, FREDERIC WOODWARD (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: addiction;Address;Agreement;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Anterior;Anxiety;anxiety-like behavior;Behavior;Behavioral;Cells;chronic alcohol ingestion;Clinical;comorbidity;compulsion;Data;Devices;drinking;economic cost;Electrophysiology (science);Emotional;experimental study;Female;Goals;Health;Heavy Drinking;Human;Implant;in vivo;Individual;Insula of Reil;Intake;Link;male;Measures;Mediating;Mediator;Medical;men;Methods;Mood Disorders;Motivation;negative affect;Neurons;neuropsychiatry;new therapeutic target;novel;Nucleus Accumbens;optogenetics;Output;Pattern;personalized medicine;Prevalence;Probability;Property;rapid detection;Rattus;response;Rodent;Role;sex;Sex Differences;social;Testing;Woman;Work

PROJECT_TITLE: Anterior Insula Projections for Alcohol Drinking/Anxiety Interactions in Female and Male Rats

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Public Health Relevance Statement Latinx gay/bisexual men and men who have sex with men experience disproportionately high HIV prevalence, a burden intensified among immigrant Latinx populations. Yet, scientifically tested HIV prevention interventions for those populations remain scarce. This proposal strongly aligns with the goals of the RFA on Transformative Research to Address Health Disparities and Advance Health Equity at Minority serving Institutions; and it directly addresses NIH’s UNITED Initiative of fostering racial equity and inclusion in biomedical research. We propose to determine the effectiveness of a community-based HIV prevention intervention (Hermanos de Luna y Sol) to reduce HIV sexual risk behavior among Latinx immigrant men who identify as gay/bisexual or men who have sex with men. The intervention was developed in Spanish with input from community members. If effective, it could be relatively easy to disseminate and, hence, improve the efforts to reduce HIV incidence and related inequities across racial/ethnic and sexual minority groups.

PI_NAMEs: SANCHEZ-VAZNAUGH, EMMA V. (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Area;Awareness;base;Behavioral;bilingualism;Biomedical Research;Bisexual;Buffers;Centers for Disease Control and Prevention (U.S.);Chicago;Cities;Collaborations;Communities;community building;Community Health;community intervention;community involvement;community organizations;contextual factors;Country;design;Diagnosis;Discrimination;distrust;effective intervention;effectiveness evaluation;Effectiveness of Interventions;Equation;ethnic minority population;Ethnic Origin;Evidence based intervention;experience;Face;Fostering;Gays;Goals;Government;group intervention;Health;health disparity;health equity;health inequalities;Heart;Hispanic-serving Institution;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;Homophobia;Human immunodeficiency virus test;Human Resources;Immigrant;improved;Incidence;Individual;Inequity;infection rate;Informal Social Control;innovation;insight;Interdisciplinary Study;Intervention;Intervention Studies;Language;Latin American;Latino;Latino Population;Latinx;Latinx population;Lead;Location;male;marginalized community;marginalized population;member;men;men who have sex with men;migration;Minority-Serving Institution;Modeling;multidisciplinary;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;novel;Observational Study;Participant;Patient Recruitments;pedagogy;Persons;Population;pre-exposure prophylaxis;Prevalence;prevent;preventive intervention;prospective;psychological distress;public health priorities;public health relevance;Quasi-experiment;queer;Race;Racial Equity;racial minority population;racism;Randomized;recruit;Research;Risk;Risk Behaviors;Sampling;Sampling Biases;self esteem;Self Perception;Sexual Health;sexual minority group;sexual risk behavior;sexual risk reduction;Shapes;social;social culture;social epidemiology;Social isolation;Social support;sociocultural determinant;Spanish;Spanish/English;Testing;therapy design;Time;time use;Translations;United States;United States National Institutes of Health;Unsafe Sex;uptake;Use Effectiveness;volunteer;Woman

PROJECT_TITLE: Hermanos de Luna y Sol: A community-based HIV prevention intervention


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE  Attention-deficit/hyperactivity disorder (ADHD) is a central component in an early causal pathway to future mental and physical health problems, relationship issues, suicide, and premature death, thus an important public health concern. A multinutrient dietary supplement has demonstrated promising benefit for ADHD and its often-accompanying feature, emotional dysregulation, in three randomized clinical trials, but in majority white, non-Hispanic populations. To increase diverse research participation, focus groups will seek input from racially and ethnically diverse communities on their needs and priorities to inform a feasibility study testing the acceptability of: 1) the multinutrient supplement; and 2) refined collection methods designed to reduce research participant burden and increase data sensitivity while exploring how the multinutrients confer benefit.

PI_NAMEs: JOHNSTONE, JEANETTE M (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: 12 year old;Academic Medical Centers;acceptability and feasibility;addiction;Address;Adult;Affect;Anger;Anxiety Disorders;Area;Attention deficit hyperactivity disorder;Award;behavior change;Behavioral;Biological;Biological Markers;Black race;Blood;Blood capillaries;career development;Caregivers;Caring;Cessation of life;Child;Child Behavior;Child Mental Health;Childhood;Chronic;Clinical Trials;Collaborations;Collection;Communities;community engagement;Complementary Health;Conduct Clinical Trials;cytokine;Data;Data Collection;design;Development;Devices;Diagnosis;Dietary Component;dietary supplements;Disease;Ecological momentary assessment;Elements;emotion dysregulation;Enrollment;Ensure;ethnic diversity;Evaluation;Failure;Family;Feasibility Studies;Feedback;Focus Groups;Foundations;Frequencies;Future;Goals;Grant;Health;Health Priorities;Healthcare;Hispanic;Home;Hour;Immune;Impairment;improved;Individual;Integrative Medicine;Intervention;Intervention Studies;Investigation;K-Series Research Career Programs;Leadership;Measures;Mediator;Mental Depression;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mindfulness;Minerals;Modeling;National Center for Complementary and Integrative Health;Neurodevelopmental Disorder;Neuroimmune;Neuroimmune system;neuroinflammation;Neurotransmitters;Not Hispanic or Latino;novel;Nutrient;Occupations;open label;Outcome;parenting intervention;Parents;Participant;Pathway interactions;patient population;Patients;physical conditioning;Plasma;Population;Population Heterogeneity;potential biomarker;premature;Preparation;Problem behavior;Process;programs;Protocols documentation;Public Health;public health priorities;racial diversity;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;Reporting;Research;Research Design;Research Methodology;Resources;response;sample collection;Sampling;Self Administration;side effect;Signal Transduction;skills;Specimen;standard care;substance misuse;Suicide;Supplementation;Symptoms;Testing;Theoretical model;Time;Training;Urine;Vitamins;Writing

PROJECT_TITLE: Optimizing Research Methodology in a Multinutrient Study of Racially and Ethnically  Diverse Children with ADHD and Emotional Dysregulation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: DENVER

ORG_DEPT: BIOLOGY

ORG_NAME: METROPOLITAN STATE UNIVERSITY OF DENVER

ORG_STATE: CO

PHR: Project Narrative A diverse community of genomic scientists are needed to fully support biomedical research and translation into the clinic. To train the next generation of genomic scientists, we present a partnership between the diverse, Hispanic-serving Metropolitan State University of Denver with the world-renowned genomics research at the University of Colorado Denver’s Downtown and Anschutz Medical Campuses. As part of the “Pathways in Genomics Research Experiences for Undergraduates (PATH-GREU) from underrepresented groups” program, we will recruit, train, and build a community of genomic scientists from groups traditionally underrepresented in biomedical research.

PI_NAMEs: DURAN, KRISTY L. (contact);HENDRICKS, AUDREY E;LIU, HSIU-PING

PROGRAM_OFFICER_NAME: TINGLE, SHARNA R

PROJECT_TERMS: Academia;Biology;Biomedical Research;career;Chemistry;Clinic;Colorado;Communication;Communities;community building;community college;computer science;County;Creativeness;Data Science;Data Scientist;Development;disability;Dryness;Education;Educational workshop;Enrollment;Ensure;Ethnic Population;Event;experience;faculty mentor;falls;Fostering;genome sciences;genomic data;Genomics;Goals;graduate school;graduate student;Grant;Health;Hispanic;human genomics;Industry;Inequity;innovation;Institution;interest;Internships;Knowledge;Laboratory Research;Learning;learning community;Life;Mathematics;Medical;member;Mentors;Mentorship;metropolitan;Minority-Serving Institution;Mission;next generation;Pathway interactions;peer coaching;Persons;Physics;Population;Positioning Attribute;posters;programs;recruit;Research;Research Support;Research Training;Rotation;Science;Scientist;skill acquisition;skills;STEM field;Structure;Students;summer internship;supportive environment;Time;Training;Training Programs;Translations;twelfth grade;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Pathways in Genomics Research Experiences for Undergraduates from Underrepresented Groups


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Adolescents and young adults (AYAs) with cancer enroll in therapeutic clinical trials at low rates, but limited research has evaluated the underpinnings of low trial enrollment in this vulnerable group, or the extent to which disparities in trial enrollment exist by race, ethnicity, socioeconomic status, and rural versus urban geography. The proposed study will evaluate disparities in enrollment to therapeutic clinical trials among AY As with cancer aged 12-29, with a focus on three key barriers: structural, individual, and interpersonal. We will examine availability and access to clinical trials for AYAs in 3 diverse states, Louisiana, New Mexico, and Tennessee, and use surveys and audiotaped encounters to examine individual and interpersonal barriers to trial enrollment, using results to develop high yield strategies for intervention in a diverse population of AYAs.

PI_NAMEs: MACK, JENNIFER W (contact);SANTANA, VICTOR M

PROGRAM_OFFICER_NAME: LEWIS, DENISE

PROJECT_TERMS: Address;Adherence;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;age group;aged;American Indians;Area;Attention;Audiotape;Belief;Black race;Cancer Center;Caregivers;Caring;Child;clinical trial enrollment;Clinical Trials;Collaborations;Communication;Community Clinical Oncology Program;cost;Data;data registry;data sharing;Development;Diagnosis;Disparity;Eligibility Determination;Enrollment;ethnic diversity;Ethnic Origin;experience;Family;Family Caregiver;Family member;Geography;Goals;health communication;health disparity;Hispanic;improved;Income;Individual;Inferior;interest;Intervention;Interview;Location;Longterm Follow-up;Louisiana;Low income;Malignant Neoplasms;neoplasm registry;New Mexico;Newly Diagnosed;older adult;Oncologist;Oncology;Patients;Population;population based;Population Heterogeneity;Poverty;Process;programs;Progress Review Group;Psychology;Race;racial difference;racial disparity;racial diversity;rare cancer;Research;Research Priority;Rural;rural area;Site;socioeconomic disparity;Socioeconomic Status;socioeconomics;Surveys;survivorship;Tennessee;Therapeutic Clinical Trial;Therapeutic Trials;trial enrollment;Underrepresented Populations;United States;urban area;urban residence;Vulnerable Populations;willingness;Work

PROJECT_TITLE: Disparities in Clinical Trial Enrollment among Adolescents and Young Adults with Cancer

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Overall NARRATIVE The SPORE will improve outcomes for ovarian cancer patients by using innovative drugs and/or combinations that target drug resistant ovarian cancer cells and tumor-associated blood vessels, based on the abnormalities in each cancer.

PI_NAMEs: BAST, ROBERT C;SOOD, ANIL K (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Affect;Algorithms;angiogenesis;Angiogenesis Inhibitors;anti-cancer research;Autoantibodies;bevacizumab;Biological Markers;Biology;biomarker identification;biomarker panel;Biopsy;Blood Vessels;CA-125 Antigen;cancer cell;Cancer Center;Cancer Patient;Carboplatin;career;Caring;Cell Therapy;chimeric antigen receptor natural killer cells;Clinical;Clinical Trials;Combined Modality Therapy;conventional therapy;CSF1R gene;Cytotoxic Chemotherapy;Development;Diagnosis;Disease;docetaxel;Drug resistance;Drug Targeting;Early Detection Research Network;effective therapy;efficacy testing;EGF-Like Domain;EGFL6 gene;Environment;EP300 gene;Epidermal Growth Factor;Exhibits;Future;Goals;Histologic;Human;humanized monoclonal antibodies;immune checkpoint blockade;immune checkpoint blockers;Immune checkpoint inhibitor;Immunologic Memory;improved;improved outcome;Infrastructure;inhibitor;innovation;Institution;International;Laboratories;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;Measures;MEKs;Molecular;Monoclonal Antibodies;Moon;Morbidity - disease rate;Natural Killer Cell toxicity;Natural Killer Cells;novel;novel therapeutic intervention;novel therapeutics;objective response rate;Outcome;Ovarian;Paclitaxel;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phase III trial;Philanthropic Fund;Phosphotransferases;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;preclinical study;predicting response;pressure;programs;Progression-Free Survivals;recruit;Recurrence;Relapse;Research;Research Design;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Risk;screening;Signal Transduction;Sodium Chloride;Speed;Surface Antigens;T cell infiltration;targeted agent;Testing;Therapeutic Monoclonal Antibodies;therapy development;therapy resistant;Time;TP53 gene;Translating;translational study;treatment strategy;trophoblast;tumor;Tumor Angiogenesis;tumor microenvironment;Underrepresented Minority;University of Texas M D Anderson Cancer Center;Vascular Endothelial Growth Factors;Wages;Woman;Women's mortality;women's outcomes;Work;wound healing

PROJECT_TITLE: The University of Texas MD Anderson Cancer Center SPORE in Ovarian Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: SOOD, ANIL K (contact)

PROJECT_TERMS: Administrator;Advocate;anti-cancer research;Basic Science;Bioinformatics;Biostatistics Core;Cancer Center;career;Clinical;Clinical Trials;Collaborations;Communication;data quality;data sharing;Development;Discipline;Disputes;Ensure;Evaluation;Goals;improved;Institution;inter-institutional;interdisciplinary approach;Malignant neoplasm of ovary;Mentorship;Monitor;Ovarian;Pathology;Patients;Policies;Policy Compliance;Procedures;Process;programs;quality assurance;Quality Control;recruit;Regulation;Reporting;Research;Research Personnel;Resolution;success;timeline;Translating;Underrepresented Minority;University of Texas M D Anderson Cancer Center;Woman;women's outcomes

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project 1 NARRATIVE Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year, and its poor outcomes are related to delayed diagnosis and development of resistance to conventional therapy with carboplatin, paclitaxel and PARP inhibitors. Inhibition of salt induced kinase 2 (SIK2) has enhanced sensitivity to all three agents. Our proposal will explore the ability of GRN-300, a SIK-2 inhibitor, to enhance response to the PARP inhibitor olaparib and to immune checkpoint blockade, enhancing their antitumor activity.

PI_NAMEs: BAST, ROBERT C (contact)

PROJECT_TERMS: Affect;Binding;Biopsy;Blood;brca gene;BRCA mutations;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;cancer type;Carboplatin;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;checkpoint therapy;Chromatin;Clinical;conventional therapy;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Diagnosis;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;DNA Repair Pathway;DNA replication fork;DNA Sequence Alteration;Dose;Double Strand Break Repair;Enhancers;Excision;Exhibits;EXO1 gene;experience;FANCD2 protein;first-in-human;FOXP3 gene;Frequencies;Gene Expression;Genetic Transcription;Germ Lines;Goals;HDAC4 gene;homologous recombination;homologous recombination deficiency;Human;IL2RA gene;IL6 gene;immune checkpoint blockade;Immunotherapy;Impairment;Infiltration;inhibiting antibody;inhibitor;IRF3 gene;ITGAM gene;Malignant neoplasm of ovary;Malignant Neoplasms;Marrow;Maximum Tolerated Dose;Mediating;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA Expression;Mus;Muscle Cells;Myeloid-derived suppressor cells;Myelosuppression;Names;novel;Nuclear;Nucleic Acid Regulatory Sequences;Organoids;Outcome;Ovarian;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;phase I trial;Phase Ib Trial;Phosphorylation;Phosphotransferases;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;preclinical study;prevent;Primary Neoplasm;programmed cell death ligand 1;Progression-Free Survivals;recombinational repair;refractory cancer;Regulatory T-Lymphocyte;Relapse;Repression;Resistance;Resistance development;response;restoration;Sampling;Second Look Surgery;Site;Sodium Chloride;Stimulator of Interferon Genes;T cell infiltration;T-Lymphocyte;targeted agent;TBK1 gene;Testing;TGFB1 gene;Toxic effect;transcriptome sequencing;tumor;University of Texas M D Anderson Cancer Center;Woman;Xenograft procedure

PROJECT_TITLE: The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project seeks to perform new analyses beyond GWAS on three large datasets from Mayo Clinic and the UK Biobank to improve risk assessment of pancreatic cancer, for which no prevention or early detection is widely available for the majority of the population. The enhanced risk score will then be tested in a novel way on a large dataset of first-degree relatives of pancreatic cancer patients to compare performance of risk models. The results are anticipated to shift the paradigm for risk counseling.

PI_NAMEs: OBERG, ANN LAURA (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: biobank;Cancer Etiology;cancer predisposition;carrier status;Cessation of life;Clinic;Counseling;Data;Data Set;design;Detection;Development;Diagnosis;Disease;disease-causing mutation;DNA;Early Diagnosis;Epidemiology;exome;exome sequencing;Family;Family history of;First Degree Relative;Future;Gene Mutation;General Population;Genes;Genetic;Genetic Counseling;genetic epidemiology;genetic information;Genetic Predisposition to Disease;Genetic Risk;genetic testing;genome wide association study;genomic data;Genotype;Germ Lines;Goals;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;high risk;high risk population;improved;Incidence;Individual;Informatics;Inherited;innovation;insight;Intervention;large datasets;lifetime risk;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;minimally invasive;Modeling;non-genetic;novel;Oncogenes;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Participant;Pathogenicity;Patients;Performance;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Prevention;Primary Care;primary care clinic;Process;prospective;Publishing;Questionnaires;rare cancer;Recommendation;Recording of previous events;recruit;Reporting;Risk;Risk Assessment;Risk Factors;risk stratification;Screening for cancer;SEER Program;Standardization;Survival Rate;Susceptibility Gene;Syndrome;Testing;Time;translational impact;United States;Validation;Variant;virulence gene;Work

PROJECT_TITLE: Multifactor risk scores with susceptibility gene mutations to enhance risk assessment of pancreatic cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE A universal analytical platform will be developed to thoroughly screen biological samples. Sample preparation, analysis, and detection will be incorporated into an automated system to expedite analyses without the need for user intervention. Developing a tool to conveniently validate the biomolecular composition of a sample is a critical step towards increasing the accuracy of subsequent biomedical research studies.

PI_NAMEs: LINZ, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: analytical method;Biological;Biomedical Research;Cells;Chemicals;Consumption;Detection;Development;Devices;disulfide bond;Dreams;Electrophoresis;Evaluation;Gel;gel electrophoresis;Government;Heart;Higher Order Chromatin Structure;improved;Industry;innovation;Intervention;Label;Laboratories;Manuals;Measurement;micro-total analysis system;Microfluidic Microchips;neglect;Peptides;Preparation;protein structure;Reproducibility;Research Personnel;research study;Risk;RNA;Sampling;Scheme;Science;Structure;sugar;Sulfate;System;Techniques;Temperature;Time;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Automated Electrophoresis Platform to Streamline Validations of Biomedical Samples


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project 2 NARRATIVE We identified TROP2 as a highly promising and safe therapeutic target for CAR-NK therapy against ovarian cancer based on extensive preclinical and pre-IND studies. Here, we propose a Phase I/II clinical trial to test the safety and efficacy of TROP2-targeting CAR-NK cells in platinum-resistant ovarian cancer. In addition, we propose to develop the next-generation TROP2-targeting CAR-NK cells by silencing the metabolic checkpoint CREM to further enhance their potency and metabolic fitness.

PI_NAMEs: REZVANI, KATY  (contact)

PROJECT_TERMS: Adoptive Transfer;aerobic glycolysis;Allogenic;Autologous;B lymphoid malignancy;B-Lymphocytes;biobank;CAR T cell therapy;CASP9 gene;CD19 gene;Cell Therapy;Cells;cellular transduction;Cessation of life;checkpoint inhibition;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Research;cost;Cryopreservation;Cyclic AMP;Cyclic AMP Response Element;cytokine;Data;design;Dose;effective therapy;Effector Cell;Endowment;engineered NK cell;Engineering;Event;Exhibits;first-in-human;fitness;Gene Deletion;Gene Modified;Generations;Genes;genetically modified cells;graft vs host disease;Hematologic Neoplasms;human study;immune checkpoint;Immune Targeting;Immunosuppression;improved outcome;In Vitro;in vivo;innovation;Institutional Review Boards;interest;Interleukin-15;intraperitoneal;Lactic acid;Lymphoid Cell;lymphoid neoplasm;Malignant Female Reproductive System Neoplasm;Malignant lymphoid neoplasm;Malignant neoplasm of ovary;manufacturing cost;manufacturing process;Membrane Glycoproteins;Metabolic;metabolic fitness;mortality;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;next generation;NK cell therapy;Normal tissue morphology;novel;novel strategies;Pathway interactions;Patients;peripheral blood;Peritoneal;Peritoneal Fluid;pharmacologic;Phase I/II Clinical Trial;Platinum;point of care;Population;pre-clinical;pre-IND studies;Preparation;Proliferating;Proteomics;Protocols documentation;Publishing;Reporting;Research;Resistance;response;Retroviral Vector;Safety;safety testing;Sampling;Secondary to;Signal Transduction;Solid Neoplasm;Specificity;success;suicide gene;Surface Antigens;T-Lymphocyte;Testing;therapeutic target;Time;Toxic effect;transcription factor;transcriptomics;Translations;trophoblast;tumor;Tumor Antigens;tumor microenvironment;Umbilical Cord Blood;University of Texas M D Anderson Cancer Center;vector

PROJECT_TITLE: Next-Generation Engineered NK Cell Immunotherapy for Ovarian Cancer