NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: REVEAL PHARMA

PHR: Project Narrative Gadolinium based contrast agents (GBCAs) are used with MRI to detect and stage cancers and other diseases and to guide treatment. However there are safety concerns about the potentially toxic gadolinium metal ion. We have invented a gadolinium-free contrast agent to replace GBCAs. The goal of this proposal is to test the safety and imaging efficacy of this new agent RVP-001 in patients with brain cancer or other brain disorders.

PI_NAMEs: HOFFMAN, VERA  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: 3-Dimensional;Abdomen;Acute;Address;Adult;adverse event monitoring;Affect;Angiography;Animal Model;Applications Grants;Area;Arteries;Authorization documentation;Award;Biodistribution;Black Box;Blood;bone;Brain;Brain Diseases;Cancer Detection;Cancer Survivor;Central Nervous System;chemotherapy;Chronic Kidney Failure;Clinical;Clinical Data;clinical development;Clinical Trials;comorbidity;Compensation;contrast enhanced;contrast enhanced computed tomography;contrast imaging;Contrast Media;Cyclic GMP;Deposition;Devices;Diagnostic Neoplasm Staging;Disease;Dissociation;Dose;Drug Kinetics;Electrocardiogram;End stage renal failure;Enhancing Lesion;Enrollment;Equilibrium;European;Excretory function;Family suidae;first-in-human;follow-up;Future;Gadolinium;General Hospitals;glomerular filtration;Goals;Grant;Hepatobiliary;high risk;High-Risk Cancer;Image;imaging study;improved;Injections;Injury to Kidney;invention;Ions;Kidney;Kidney Diseases;Kidney Failure;Lesion;Life;Macaca fascicularis;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Manganese;manufacture;Marketing;Massachusetts;Medical;Medicine;Metals;Modeling;Monkeys;Mus;Myocardial Infarction;Nephrogenic Systemic Fibrosis;nephrotoxicity;New Agents;Papio;Patient imaging;Patient Monitoring;patient population;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Pharmacology Study;Phase;phase 1 study;Physicians;Population;Rattus;Renal function;Resolution;Risk;Rodent;Safety;safety assessment;safety testing;screening;Signal Transduction;Site;Suspending Agents;Technology;Time;Toxic effect;Toxicology;tumor;United States National Institutes of Health;uptake;Venous blood sampling;Vial device;Woman

PROJECT_TITLE: Manganese Based MRI Contrast Agent


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Estrogen;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: ATHENS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Traumatic brain injury (TBI) is a leading cause death and long-term disability however, differing recovery outcomes have been observed between male and female children. Although these differences in recovery have been associated with basic patient factors (e.g., age, sex), current prognostic models fail to fully account for these variances in TBI recovery. As such, this proposal will utilize a representative piglet TBI model to further understand the effects of sexually dimorphic neuroanatomical structures on changes in cellular processes, functional neural networks reorganization, and cognitive, behavioral, and motor function post-TBI.

PI_NAMEs: WEST, FRANKLIN D (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Age;aged;American;Anatomy;Atrophic;Behavior;Behavioral;Body Size;Brain;brain volume;Cause of Death;Cell Physiology;Cessation of life;Child;Childhood;Chronic;Cognition;Cognitive;Cognitive deficits;Compensation;Data;deep learning model;Development;Disease;Dorsal;Emergency department visit;Emotional;Endocrine;Family suidae;Female;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;gait examination;graph theory;gray matter;Hippocampus;Hospitalization;Human;Hypothalamic structure;Impairment;improved;Injury;innovation;insight;Knowledge;Learning;Long term disability;Magnetic Resonance Imaging;male;Measures;Memory;Modeling;Motor;motor function recovery;nerve injury;neural;neural network;Neuroanatomy;neurodevelopment;neuroprotection;novel;object recognition;Outcome;Pathway interactions;Patients;pediatric traumatic brain injury;Performance;Pituitary Gland;porcine model;Positioning Attribute;Predisposing Factor;prognostic model;psychosocial;putamen;Recovery;Recovery of Function;Reporting;Research Personnel;Resolution;response to injury;Rest;restoration;Risk Factors;Rodent Model;Severities;sex;Sex Differences;sexual dimorphism;social;Structure;Testing;Time;translational potential;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States;white matter;Work

PROJECT_TITLE: The Effect of Sex Dimorphisms on TBI Injury and Recovery

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Non-typhoidal Salmonella serotypes are the single most common cause of death from diarrheal disease associated with viruses, parasites or bacteria and the leading cause of foodborne disease outbreaks in the United States, producing between $0.5 billion to $2.3 billion in annual costs for medical care and lost productivity. The most common human clinical isolate is Salmonella enterica serotypes Typhimurium (S. Typhimurium). Research proposed in this application will support pioneering studies on molecular mechanisms that control the balance between the pathogen, the host and its microbiota. The proposed studies will drive knowledge about Salmonella gastroenteritis to a higher level by providing critical new insights into pathogenesis and mechanisms that enable the pathogen to overcome colonization resistance mediated by the gut microbiota.

PI_NAMEs: BAUMLER, ANDREAS J (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Address;Affect;Anaerobic Bacteria;Bacteria;Bile Acids;Cause of Death;Cell Respiration;Clinical;Colon;colonization resistance;Colorectal Cancer;Communities;Complex;diarrheal disease;Disease;Disease Outbreaks;dysbiosis;Ecosystem;Education;enteric pathogen;Enterobactin;Environment;Epithelium;Equilibrium;expectation;experimental study;foodborne illness;Gastroenteritis;Goals;Growth;gut inflammation;gut microbiota;Health;host-associated microbial communities;Human;Immune;Immune response;Infection;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;innovation;insight;interest;Intestines;Invaded;Iron;Knowledge;LCN2 gene;Link;Mediating;Medical Care Costs;microbial;microbial community;microbiota;microbiota composition;Modeling;Modification;Molecular;Neurotransmitters;non-typhoidal Salmonella;Nutrient;nutrition;Parasites;pathogen;Pathogenesis;Phase;Physiology;polyol;Production;Productivity;public health relevance;Research;Research Personnel;Resources;Salmonella;Salmonella enterica;Salmonella typhimurium;Serotyping;shift work;Sulfides;Sulfur Metabolism Pathway;Testing;Time;United States;Virulence Factors;Virus;Work

PROJECT_TITLE: Microbiota outgrowth by Salmonella

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Preterm infants who are mechanically ventilated face increased risk of developing brain injury and neurodevelopmental problems, but we do not understand the link between mechanical ventilation and increased risk of brain injury in preterm newborns. The goal of this proposal is to test the hypothesis that mechanical ventilation causes pulmonary cells to release vesicles that penetrate the brain and induce brain cell death. If we can understand what is causing brain cell death in mechanically ventilated preterm newborns, we may be able to develop therapeutic strategies to improve the neurodevelopmental outcomes of these vulnerable infants.

PI_NAMEs: SANTOS SCHMIDT, AUGUSTO F (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Adoptive Transfer;Advisory Committees;Age Months;Animals;Area;Blood Circulation;blood-brain barrier crossing;Brain;brain cell;Brain Injuries;Bronchopulmonary Dysplasia;career;career development;CASP1 gene;Caspase;Cell Death;Cell membrane;Cells;Cessation of life;Circulation;Clinical;Collaborations;Complement;cytokine;dalton;Data;Development;doctoral student;Dyes;Enzyme-Linked Immunosorbent Assay;ex vivo imaging;exosome;Extremely Low Birth Weight Infant;Face;Fellowship;Foundations;Genetic;genetic approach;Goals;high risk infant;Hyperoxia;Immunohistochemistry;improved;Induced Neurons;Infant;Inflammation;Inflammatory;inhibitor;Injury;insight;interest;interleukin-1beta-converting enzyme inhibitor;Intervention;Knock-out;Knockout Mice;Knowledge;Label;Laboratories;Life;Link;loss of function;Lung;lung injury;Lytic;Mechanical ventilation;Mediating;Medical Students;Mentors;Modeling;Morbidity - disease rate;mouse model;Mus;myelination;Neonatal;Neonatal Brain Injury;neonatal lung injury;Neonatology;neurobehavioral;neurobehavioral test;Neurodevelopmental Impairment;Neurodevelopmental Problem;neuroinflammation;neuron loss;Neurons;neurosurgery;new therapeutic target;Newborn Infant;novel;Outcome;Paralysed;Pathogenesis;Pathway interactions;Pediatric Hospitals;Pediatrics;Penetration;pharmacologic;Physicians;Placebos;Play;Population;Postdoctoral Fellow;Premature Infant;Preterm brain injury;preterm newborn;prevent;Principal Investigator;Process;professor;pulmonary function;Randomized;Rattus;Research;Research Proposals;Residencies;respiratory;Risk;Rodent;Role;Scientist;Serum;skills;Survival Rate;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tidal Volume;Time;Training;Training Programs;Universities;ventilation;vesicular release;Visualization;Water;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Exosomal-mediated pyroptosis in ventilation-associated preterm brain injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Studies in mice and humans highlight the importance of antibody-dependent cell-mediated cytotoxicity (ADCC) in the prevention of herpes simplex virus infections. The goal of this application is to isolate and characterize monoclonal antibodies elicited by DgD-2, a novel candidate vaccine, with this protective activity and to define the role HVEM signaling pathways play in generating these IgG subclass switched ADCC antibodies. The results obtained will have broad implications and accelerate the development of strategies to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.

PI_NAMEs: HEROLD, BETSY C. (contact);KURAOKA, MASAYUKI

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;Acute;Address;Adopted;Antibodies;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;B-Lymphocytes;Binding;Biological Markers;cell type;Cells;Clinical;Clinical Trials;Complement;congenic;Cryoelectron Microscopy;Cytolysis;Data;Development;Disease;Dose;Ebola virus;Engineering;Epitopes;Exhibits;Female;Generations;Genitalia;glycoprotein D-herpes simplex virus type 2;Glycoproteins;Goals;Herpes Simplex Infections;Herpesvirus 1;herpesvirus entry mediator;Human;Human Herpesvirus 2;IgG Receptors;IgG1;IgG2;Immune;Immune Evasion;Immune response;Immune Sera;Immunoglobulin G;Individual;Infection;Intercellular Junctions;Interferon Type II;Knock-out;Knockout Mice;knowledge translation;Ligands;Ligation;Light;male;Maps;Mediating;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Neonatal;neonatal mice;neonate;neutralizing antibody;novel;pathogen;Pathway interactions;Phagocytosis;Play;preclinical study;prevent;Prevention;Production;Protein Subunits;Proteins;public health priorities;receptor;Recombinants;Recurrence;response;Role;SARS-CoV-2 spike protein;Signal Pathway;Signal Transduction;Signaling Molecule;Simplexvirus;Skin;Structure of germinal center of lymph node;Subunit Vaccines;T-Lymphocyte;Testing;TNFRSF5 gene;Tumor Necrosis Factor-Beta;Up-Regulation;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine-induced antibodies;Vaccines;Vagina;Viral;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Optimizing the Generation of Monoclonal Antibodies for Prevention and Treatment of HSV Disease

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Our laboratory uses high throughput chemical screening combined with modern target identification techniques to identify novel small molecules with physiological activity. This approach results in pharmacologically privileged mechanistic information and often the chemical starting points for drug development campaigns. This work will principally focus on three key areas: identifying compounds to promote regenerative organ repair, developing small molecule activators of transcriptional stress responses, and advancing methodology to identify small molecules with novel reactivity and/or biological activity.

PI_NAMEs: BOLLONG, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Animal Model;Area;Biological;biological adaptation to stress;Carbon;Cells;Cellular Stress;Chemicals;Clinical;drug development;Enzymes;Family;Genetic Transcription;Goals;Heat-Shock Response;Knowledge;Laboratories;Language;Libraries;Ligands;Logic;Medicine;Metabolism;Methodology;Methods;Modernization;novel;organ repair;Oxidative Stress;Pathway interactions;pharmacologic;Physiological;Property;proteostasis;regenerative;Regenerative Medicine;regenerative tissue;Research;Research Personnel;response;screening;Signal Transduction;small molecule;small molecule libraries;stem cell population;Techniques;Therapeutic;tissue repair;Tissues;tool;Transcription Coactivator;Work

PROJECT_TITLE: Methods and approaches to expand the pharmacological toolset


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Latently infected CD4+ T cells are considered to be the most important HIV reservoir preventing the implementation of an HIV cure, however, myeloid cells have been shown to be infected by HIV/SIV and to establish latency in animal models. Therefore, elimination of the T cell reservoir alone is not likely to result in complete virus eradication. Our long-term goal is to aid the development of effective HIV cure strategies by gaining a better understanding of the type and location of the cells in the brain that harbor replication-competent HIV under ART suppression.

PI_NAMEs: WAHL, ANGELA RAQUEL (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Affect;Animal Model;Autopsy;Binding;Brain;brain cell;brain tissue;CD4 Positive T Lymphocytes;Cell division;Cells;Clonal Expansion;Development;DNA;Drug Kinetics;experimental study;Goals;HIV;HIV Infections;Human;humanized mouse;Individual;Infection;innovation;integration site;Interruption;Kinetics;Knowledge;Location;Macrophage;Microglia;mouse model;Myeloid Cells;neuroAIDS;Neurocognitive;novel;Pathology;Penetration;Performance;Persons;Population;prevent;reconstitution;Regimen;Reporting;Rest;Role;Sampling;self-renewal;SIV;Source;T-Lymphocyte;Tissues;viral rebound;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: The Role of Myeloid Cells in HIV Latency and Persistence in the Brain

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Non-typhoidal Salmonella enterica is a leading cause of bacterial foodborne gastroenteritis and causes the most deaths of any foodborne pathogen in the United States. Here, we will explore how Salmonella regulates its response to sulfite stress produced by the innate immune system. Since sulfites are antibacterial reactive sulfur species with widespread availability in the host, our work will lead to new therapeutic strategies to combat Salmonella infections.

PI_NAMEs: ELFENBEIN, JOHANNA REBECCA (contact)

PROJECT_TERMS: amino acid metabolism;Amino Acids;Anabolism;Anti-Bacterial Agents;antimicrobial;Area;Bacteria;Bacterial Infections;Binding;Biogenesis;biological adaptation to stress;Cause of Death;Cell Physiology;Cessation of life;ChIP-seq;combat;Cysteine;Data;density;Disease;DNA;Drug Metabolic Detoxication;Enteral;enteric infection;enteric pathogen;Evaluation;Flagella;Food;foodborne;foodborne illness;foodborne pathogen;Future;Gastroenteritis;Gene Expression;gene repression;Genes;genetic approach;Genetic Transcription;Growth;gut colonization;high reward;high risk;Homologous Gene;human pathogen;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Innate Immune Response;Innate Immune System;Intestines;Libraries;Life;Link;Lipids;Lipopolysaccharides;Liver;Mediating;Methionine;Microbe;Modeling;mouse model;Mus;mutant;neutrophil;Neutrophil Infiltration;non-typhoidal Salmonella;novel therapeutic intervention;Organ;Orthologous Gene;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Phase;Play;prevent;Process;Production;promoter;Proteins;Pseudomonas aeruginosa;Publishing;Reaction;Regulation;Regulon;Repression;Resistance;response;Role;Salmonella;Salmonella enterica;Salmonella infections;Sepsis;Side;Signaling Molecule;Spleen;Stimulus;Stress;Sulfate;Sulfite reductase;Sulfites;Sulfur;Systemic infection;Testing;Toxic effect;transcriptome;United States;Vibrio cholerae;Virulence;Virulence Factors;Work;Yersinia enterocolitica

PROJECT_TITLE: Mechanistic evaluation of resistance to sulfite toxicity in Salmonella

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Biotechnology;Maternal Health;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Placental dysfunction, in particular changes in placental nutrient delivery, contributes to many important pregnancy complications and has been linked to disease in childhood and in adult life. Very little information is available on placental phospholipid synthesis or the role of these lipids in regulating placental function and delivering essential lipids to the fetus. We expect that the results from the proposed work will ultimately lead to new understanding of the causes for placental dysfunction in pregnancies complicated by growth restriction, and maternal diabetes and could help to improve life long health of children whose development was affected by these conditions.

PI_NAMEs: POWELL, THERESA L (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acyltransferase;Address;Adult;Affect;alpha-glycerophosphoric acid;Amino Acid Transport System A;Amino Acids;Arachidonic Acids;blastocyst;Blood;Blood - brain barrier anatomy;Blood specimen;Brain;cancer cell;Cell membrane;Cells;Child Health;Childhood;Choline;choline transporter;Circulation;Complex;Data;Deposition;Development;Disease;Docosahexaenoic Acids;enzyme activity;enzyme pathway;Enzymes;Epithelium;Fatty acid glycerol esters;Fatty Acids;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;FRAP1 gene;Functional disorder;Gene Silencing;Gene Targeting;Gestational Diabetes;Growth;Human;improved;Incubated;innovation;inorganic phosphate;knock-down;Label;Lentivirus;Life;Link;lipid metabolism;Lipids;Lysophosphatidylcholines;maternal diabetes;Measures;Mediating;Mediator;Mitochondria;Mus;Nonesterified Fatty Acids;novel;Nutrient;Oleic Acids;Outcome;Phosphatidic Acid;Phospholipase A2;Phospholipids;Physiological;Placenta;placental transfer;Pregnancy;Pregnancy Complications;Protein Biosynthesis;Protein Isoforms;Reporting;Respiration;Role;Signal Transduction;Small Interfering RNA;Stable Isotope Labeling;Syncytiotrophoblast;Testing;Tissues;Transferase;trophoblast;Umbilical Blood;Umbilical vein;Western Blotting;Work

PROJECT_TITLE: Novel Roles for Phospholipids in Regulating Placental Function and in the Delivery of DHA to the Fetal Brain.

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Justification (Project Narrative) Deciphering the interactions of microbes with each other and their host habitats is essential for understanding the oral microbiome's role in health and disease and for developing preventive and therapeutic strategies. Currently, we lack sufficient understanding of why bacteria live where they do in the mouth—such as on teeth, tongue or gums--to accomplish these goals. This proposal will close that knowledge gap using bioinformatic tools and in-depth analysis to establish a genomic, ecologic framework that will eventually enable clinicians to treat oral diseases through knowledge-based manipulation of bacterial composition.

PI_NAMEs: BORISY, GARY G (contact);DEWHIRST, FLOYD E;EREN, A. MURAT ;MARK WELCH, JESSICA LEIGH

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Bacteria;bioinformatics tool;Biotechnology;Candidate Disease Gene;candidate identification;Communities;Complex;Data;Databases;Dental Plaque;Disease;Ecosystem;follow-up;General Practitioners;Genes;Genetic;Genome;Genomics;Goals;Habitats;Health;Human;human data;Human Microbiome;improved;in vitro Model;Individual;insight;Knowledge;Maps;Metagenomics;Microbe;microbial;microbial genome;microbiome;microbiome research;Molecular;Mouth Diseases;Oral;Oral cavity;oral microbiome;Organism;pan-genome;Pathogenesis;Population;Prevalence;Preventive;public database;Research;Research Personnel;Resources;Role;Saliva;Sampling;Site;Source;Specialist;Specificity;Testing;Therapeutic;Tongue;Tooth structure;Tropism;Visualization;whole genome

PROJECT_TITLE: Metapangenomics of the Oral Microbiome

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This proposed project will contribute vital knowledge regarding the risk factors, etiology, clinical course, and hospital outcomes in a population of children in sub-Saharan Africa (SSA) with severe febrile illness, without which providers cannot determine appropriate management, therapy, or resource allocation. Furthermore, this project will determine which point-of-care biomarker tests are clinically relevant in this setting, and develop a treatment algorithm incorporating clinical signs and biomarkers that will guide management and resource allocation with the potential to meaningfully impact outcomes for children throughout SSA.

PI_NAMEs: KORTZ, TERESA  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acute;Affect;Africa;Africa South of the Sahara;African;Algorithms;Antibiotics;Bacteremia;Bacterial DNA;Bacterial Infections;Bioinformatics;Biological Markers;Biometry;Blood;Blood Glucose;C-reactive protein;career;Cessation of life;Child;Childhood;Clinical;Clinical Data;Clinical Research;clinical risk;Clinical Trials;clinically relevant;Collaborations;Complex;Data;Data Analyses;Decision Trees;Dehydration;design;Detection;detection method;Deterioration;Development;diagnosis standard;Diagnostic;Diagnostic Procedure;Early treatment;Etiology;evidence base;Evidence based intervention;Ferritin;Fever;Funding;Future;global health;Goals;health training;Hemoglobin;high risk;Hospitals;Impairment;improved;improved outcome;Infection;infection risk;Infectious Agent;innovation;Intensive Care;Intervention;Knowledge;Laboratories;Learning;Life;Malaria;malaria infection;Measures;member;mental state;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;microbial;Modification;mortality;next generation sequencing;novel;Outcome;Parasitic infection;pathogen;Pathogen detection;pathogenic bacteria;Patients;Perfusion;Physicians;point of care;point of care testing;Population;Positioning Attribute;predictive marker;Prevalence;Probability;procalcitonin;Process;prognostic;prospective;Prospective, cohort study;Provider;rapid diagnosis;recruit;Research Infrastructure;Research Personnel;Resource Allocation;Resource-limited setting;Respiratory distress;Risk;Risk Factors;risk stratification;Sampling;San Francisco;Science;Scientist;Serum;Severities;skills;Source;Tanzania;Technology;Testing;Time;Time Management;Training;urgent care;Virus Diseases

PROJECT_TITLE: Fever Etiology and Prognostic Point-of-Care Biomarkers in African Children with Severe Febrile Illness

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Sleep Research;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We use the interface of aging and breast cancer in older women to inform geroscience and Alzheimer’s disease- related dementias (ADRD). We propose to use data from our older breast cancer survivors and non-cancer controls to elucidate the role of biological aging in cognitive and physical declines, and examine the role of sleep in these relationships. This clinical translational project addresses key NIA priority areas and will provide important data to inform future ADRD studies and interventions to improve health and resilience of our aging population.

PI_NAMEs: CARROLL, JUDITH E (contact);MANDELBLATT, JEANNE

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: actigraphy;Address;Affect;Age;age acceleration;age related;aged;Aging;aging biomarker;aging mechanism;aging population;aging process;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavior Therapy;biobank;Biological;biological age;Biological Aging;Biological Assay;Biological Specimen Banks;Biological Testing;Blood;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer therapy;Cancer Center;Cancer Control;Cancer Survivor;cancer therapy;Cell Aging;Chronology;clinical translation;Cognitive;Cognitive aging;cognitive function;cohort;comparison control;Consent;Control Groups;Data;Demographic Factors;Disease;DNA Damage;drivers of aging;Educational Status;Elderly;Enrollment;Epigenetic age;follow-up;Frequencies;functional decline;Future;Geriatrics;Geroscience;Goals;Grant;Hand Strength;Health;Heterogeneity;Homeostasis;Impaired cognition;improved;improvement on sleep;Indiana;Inflammation;Intervention;Knowledge;Lead;Length;Leukocytes;Long-Term Effects;Longitudinal cohort;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Modeling;multiple chronic conditions;Neurocognitive;neurocognitive test;Neurosciences;Newly Diagnosed;novel;Obesity;older women;Oncology;parent grant;Parents;Pathway interactions;Patient Self-Report;Pattern;Persons;Physical assessment;Physical Function;poor sleep;Population;primary outcome;prospective test;Psychosocial Factor;racial population;recruit;Regulation;repaired;Research;resilience;Risk;Role;Site;Sleep;sleep health;Survivors;Syndrome;System;Systemic Therapy;telomere;Testing;theories;Thinking;Time;transcriptome sequencing;United States National Institutes of Health;Universities;Visit;Waste Products;Woman;Work

PROJECT_TITLE: Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Title: Targeting NQO1+ tumor to trigger innate and adaptive immunity  Project Narrative Defective innate sensing in tumor microenvironment (TME) might contribute to checkpoint blockade resistance.  In  a  new  study,  we  will  demonstrate  that  a  tumor- targeting  prodrug  triggers  tumor- selective  innate  sensing  to  overcome  checkpoint  blockade  resistance  and  bridge  innate  and  adaptive  immunity.  This  prodrug  will  be  bioactivated  by  tumor- enriched  enzyme  and  overcome  immunotherapy  resistance  and  eradicate  well-   established and checkpoint blockade refractory tumors. This study implicates that proper innate sensing inside  TME might synergize with T- cell- dependent immunotherapy.

PI_NAMEs: HUANG, XIUMEI  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antigen-Presenting Cells;Antigens;beta-Lapachone;Biological Assay;cancer cell;Cause of Death;CD8B1 gene;Cells;Clinical;Combined Modality Therapy;Complex;Cross-Priming;Cytotoxic T-Lymphocytes;Diagnosis;DNA;DNA Damage;Electrons;Enzymes;Genomics;Goals;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic cell death;Immunotherapy;improved;in vivo;Individual;innate immune sensing;Interferon Type I;Interferons;Macrophage;Malignant Neoplasms;Mediating;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Mus;Natural Immunity;Necrosis;neoplastic cell;neutrophil;Neutrophil Infiltration;new combination therapies;novel;Oxidoreductase;Pattern;PD-1 blockade;Phagocytes;Pharmaceutical Preparations;pre-clinical;Prodrugs;Production;programmed cell death ligand 1;Quinones;Reactive Oxygen Species;recruit;Refractory;Relapse;Research;Resistance;resistance mechanism;response;Role;Signal Transduction;Solid;Solid Neoplasm;Source;Stimulator of Interferon Genes;synergism;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic vaccine;tumor;tumor DNA;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Suppression;Up-Regulation;uptake

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This T32 grant proposal seeks support for a “new” PhD training Program in the Pharmacological Sciences. We have a top-tier Pharmacology Program that was established in 1952, hosted jointly by the Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center (MSKCC). Our faculty is a group of highly productive biomedical researchers who share the aspiration to develop the next generation of scientists and create innovative therapies that will better our world.

PI_NAMEs: GROSS, STEVEN S (contact);PLEIL, KRISTEN ELIZABETH

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Predoctoral Training in Pharmacological Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Hematology;Mental Health;Mental Illness;Palliative Care;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Hematopoietic stem cell transplantation (HSCT) survivors experience tremendous psychological symptoms (e.g., anxiety and depression symptoms), low levels of positive psychological well-being (e.g., flourishing, gratitude), and diminished quality of life (QOL) in the setting of high rates of treatment-related toxicities, a prolonged recovery with a substantial risk of life-threatening complications, and long-term morbidity and mortality. However, scalable psychosocial interventions tailored to the unique needs of HSCT survivors which focus on psychological well-being holistically (i.e., incorporate positive psychological skills and can buffer against distress) are lacking. To address these gaps, the proposed trial assesses the efficacy of a positive psychology intervention (PATH) in HSCT survivors for improving anxiety and depression symptoms and QOL.

PI_NAMEs: AMONOO, HERMIONI L. (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Address;Affect;Allogenic;Anxiety;anxiety symptoms;Award;Behavioral Model;Black race;Buffers;Cancer Center;Chronic;Clinic;Clinical;clinically significant;coping;cost;curative treatments;Dana-Farber Cancer Institute;depressive symptoms;Diabetes Mellitus;Discipline of Nursing;Disease;Distress;efficacious intervention;efficacy evaluation;efficacy testing;Ensure;Environment;Evidence based intervention;experience;Goals;gratitude;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;High Dose Chemotherapy;high risk population;Hispanic;Hospitalization;Hospitals;improved;Individual;Intervention;Letters;Life;Malignant Neoplasms;Mediating;Mediator;Medical;Mental Depression;Meta-Analysis;Morbidity - disease rate;mortality;Nurses;Outcome;Palliative Care;Participant;Patients;Personal Satisfaction;Persons;Physical activity;physical symptom;Population;primary outcome;Psychiatrist;psychologic;psychological distress;psychological symptom;Psychologist;Psychology;psychosocial;Psychosocial Assessment and Care;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Reporting;Research;Risk;Sampling;Self Management;Site;skills;Social Work;Social Workers;Structure;Supportive care;Telephone;therapy development;Training;transplant survivor;treatment as usual;Treatment-related toxicity;Uncertainty;United States;United States National Institutes of Health;Well in self;Work;Writing

PROJECT_TITLE: Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Prevention;Rehabilitation;Sleep Research;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE 30-50% of cancer survivors who have completed treatment with curative intent have untreated insomnia, and cognitive behavioral therapy for insomnia (CBT-I) is a first line, evidence-based treatment. In response to PAR-21- 341, this resubmission aims to optimize synchronous, virtual CBT-I for cancer survivors (Survivorship Sleep Program; SSP) in a 2x2 factorial trial (N=80 cancer survivors with insomnia) by evaluating 2 intervention design components [delivery (individual vs. group) and booster sessions (0 vs. 3)] on the primary outcome (change in insomnia severity from baseline to 1-month surveillance/booster), explore study participation and sleep outcomes by race and by ethnicity using feasibility benchmarks established in our previous pilot trial, and characterize the acceptability of the SSP design components via exit interviews to characterize preferences, challenges, and future intervention delivery considerations. Bolstered by support from our community partnerships, this project will yield multiple deliverables to innovate cancer survivorship care, chiefly an optimized, scalable, virtually-delivered intervention that addresses chronic insomnia, one of the most deleterious concerns among the growing, and racially and ethnically diverse, demographic of cancer survivors in the U.S, and will inform a future R01 efficacy trial and future considerations for delivering CBT-I to cancer survivors.

PI_NAMEs: HALL, DANIEL LEE (contact)

PROGRAM_OFFICER_NAME: RICHMOND, ELLEN S

PROJECT_TERMS: Absenteeism;actigraphy;Acute;Address;anxiety symptoms;Behavior Therapy;Behavioral;Benchmarking;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Chronic Insomnia;Clinical Trials;clinically significant;Code;Cognitive Therapy;community engagement;community organizations;community partners;community partnership;Data;depressive symptoms;design;diaries;efficacy trial;Eligibility Determination;Emotional;emotional distress;Enrollment;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Evidence based treatment;experience;Feedback;follow-up;Funding;Future;Goals;High Prevalence;Hospitals;Impairment;improved;indexing;Individual;innovation;Intervention;intervention delivery;Interview;Maintenance;Malignant Neoplasms;Medical;Meta-Analysis;Methods;Modality;multiphase optimization strategy;Not Hispanic or Latino;Oncologist;Outcome;Participant;patient oriented;Persons;Pharmaceutical Preparations;pilot trial;post intervention;preference;primary outcome;Problem Solving;programs;Qualitative Methods;Race;racial diversity;racial minority;Randomized, Controlled Trials;Recommendation;recruit;relapse prevention;remote delivery;Research;Residual state;response;Sampling;satisfaction;Scientist;secondary outcome;Severities;side effect;Sleep;sleep health;Sleeplessness;Survivors;survivorship;Symptoms;synchronous delivery;Testing;therapy design;Time;Travel;treatment as usual;trial enrollment;virtual;virtual delivery;Work

PROJECT_TITLE: Innovating CBT-I for Cancer Survivors: An Optimization Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: PROJECT NARRATIVE Tens of thousands of Veterans survive critical illness annually, only to experience profound and often persistent impairments in physical function for months to years later that lead to disability and poor quality of life. Little is known, however, about the mechanisms and biological basis of physical recovery, inhibiting efforts to improve outcomes. This study will enroll 62 Veterans who survive an admission to the intensive care unit (ICU) and characterize mitochondrial function in these patients using novel metabolic imaging methods (31- phosphorus magnetic resonance spectroscopy) and blood-based biomarkers to determine the association with physical recovery up to 6 months after critical illness. This knowledge gained from this proposal will pave the way for new rehabilitation and intervention strategies to restore function and quality of life after the ICU.

PI_NAMEs: MART, MATTHEW FRANKLIN (contact)

PROJECT_TERMS: Acute;Admission activity;Adult;Award;Bioenergetics;Biological;Biological Markers;Blood;blood-based biomarker;Cardiopulmonary;career;career development;Clinical Trials;Critical Care;Critical Illness;Data;deconditioning;Dedications;Development;Development Plans;disability;effective intervention;Energy Metabolism;Enrollment;exercise capacity;Exercise Physiology;Exercise Test;experience;extracellular;Failure;follow-up;Fostering;Foundations;functional decline;Functional disorder;functional outcomes;functional restoration;Future;Generations;Goals;Grant;Health system;Heart Diseases;Hospitalization;Hospitals;imaging modality;Impairment;improved;improved outcome;Infrastructure;insight;Intensive Care Units;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measures;Medical center;Medicine;Mentors;Mentorship;metabolic imaging;Methods;middle age;Mitochondria;mitochondrial dysfunction;Mitochondrial Myopathies;Mobility decline;Muscle;Muscle Mitochondria;Muscle Weakness;Muscular Atrophy;novel;novel therapeutic intervention;observational cohort study;Outcome;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Patients;Peripheral Blood Mononuclear Cell;Phosphorus;Physical assessment;Physical Function;Physicians;Physiological;primary outcome;programs;prospective;Prospective, cohort study;quadriceps muscle;Quality of life;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;Research Training;Resources;Respiration;Role;Scientist;Skeletal Muscle;skills;successful intervention;Survivors;Tennessee;Testing;Thigh structure;Training;United States Department of Veterans Affairs;Veterans;Walking;Work;Writing

PROJECT_TITLE: The Role of Mitochondrial Dysfunction in Physical Recovery after Critical Illness

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  There is a national shortage of qualified clinician-scientists with the skills to conduct the rigorous clinical research needed to address the most vexing population-based questions in neurology. Leveraging the efforts of a distinguished, experienced, and committed training program faculty, a rigorous curriculum of both didactic training and mentored research, and a world-class biomedical research environment, this training program provides trainees with the skills needed to design, conduct, and complete high-quality epidemiologic research in clinical neurology.

PI_NAMEs: KASNER, SCOTT E (contact);WILLIS, ALLISON

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Neurologic Clinical Epidemiology Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Women's Health Research

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE In South Africa, women with HIV (WWH) are at a dramatically elevated risk for cervical cancer, which is preventable through timely screening and treatment of precancerous lesions; however, screening via Pap smears is only effective if women are retained in care, and unacceptably high rates of WWH with abnormal Pap smears are lost to follow-up. This study will (1) explore the barriers and facilitators to follow-up appointment attendance and subsequent treatment among WWH with a recent high-risk abnormal Pap smear and their providers; (2) develop a multi-level intervention to increase follow-up appointment attendance and subsequent treatment; and (3) evaluate the feasibility and acceptability of the intervention in a pilot randomized trial. If feasibility, acceptability, and preliminary efficacy are demonstrated, then the intervention will be ready for large- scale efficacy/effectiveness testing, with the ultimate goal of decreasing the incidence of cervical cancer among WWH.

PI_NAMEs: PSAROS, CHRISTINA ;STANTON, AMELIA M. (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Africa South of the Sahara;Appointment;Attention;cancer health disparity;cancer therapy;care delivery;Caring;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Clinic;Clinical;co-infection;community advisory board;community barrier;Complex;Continuity of Patient Care;Country;Cytology;Data;Development;Education;Effectiveness;effectiveness testing;effectiveness trial;Employment;Enrollment;Europe;Event;Face;feasibility testing;Feedback;follow-up;geographic disparity;Goals;health belief;high risk;HIV;HIV Seronegativity;HPV-High Risk;Human Papillomavirus;Hybrids;implementation intervention;implementation outcomes;Incidence;Income;Individual;Intervention;Interview;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Medical;Modeling;Morbidity - disease rate;North America;novel;Outcome;Outcome Study;Pap smear;Participant;participant enrollment;patient retention;Patients;Persons;Phase;post intervention;preference;premalignant;Premature Mortality;Prevalence;prevent;Provider;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Resource-limited setting;Resources;Risk;screening;screening program;secondary outcome;Self Efficacy;seroconversion;Signal Transduction;skills;South Africa;Specific qualifier value;Structure;Testing;therapy development;Time;tv watching;Vaccination;Visit;voucher;Woman;Women's prevalence;women's treatment;Work

PROJECT_TITLE: Identifying and Addressing Barriers in the Cervical Cancer Treatment Cascade among Women with HIV in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative: Three sentences. Damage to the spinal cord doesn’t heal because regrowth of injured axons is limited by the lack of growth capacity of adult neurons and by the inhibitory environment in the injury site. We use rodent models to test controlled delivery of treatments to promote axonal regeneration after injury avoiding off-target effects and study the role of the inhibitory environment when injured axons are prompted to grow. These studies are relevant as they could open the field to explore combinatorial strategies to promote optimal axonal regrowth after spinal cord injury.

PI_NAMEs: METCALFE, MARIAJOSE  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;adenovirus mediated delivery;Adult;Adverse effects;Affect;Axon;axon growth;axon injury;axon regeneration;Bilateral;Cells;Central Nervous System;Cervical spinal cord injury;Chondroitin ABC Lyase;Chondroitin Sulfate Proteoglycan;combinatorial;Communication;Corticospinal Tracts;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Digestion;Doxycycline;Environment;Evaluation;FRAP1 gene;Functional disorder;functional improvement;Genes;genetic approach;Goals;Growth;healing;Homologous Gene;Impairment;improved;improved outcome;Individual;Injections;Injury;innovation;inorganic phosphate;insight;Interruption;Intrinsic factor;knock-down;Knowledge;Lesion;Link;Mediating;motor recovery;Movement;MT3 gene;Mus;Natural regeneration;Nervous System Disorder;neural repair;neuronal growth;Neurons;novel therapeutic intervention;Paralysed;Pathway interactions;Pharmaceutical Preparations;Play;promoter;Proteins;Proto-Oncogene Proteins c-akt;Recovery of Function;Research;retrograde transport;Rodent Model;Role;Site;small hairpin RNA;Spinal Cord;Spinal cord injury;spinal tract;Structure of rubrospinal tract;System;tensin;Testing;Text;therapeutically effective;Time;transgene expression;Transgenes;Upper limb movement;Variant

PROJECT_TITLE: Regulated PTEN expression to overcome barriers to corticospinal tract regeneration after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Relevance Nearly half of all childhood cancers occur in children under 5 years of age who are at greatest cognitive risk due to a rapidly developing brain and treatment-related disruption to the early learning environment; yet, there are no studies of cognitive interventions targeting young children undergoing cancer treatment. Studies have shown caregiver education regarding the importance of the early learning environment on child brain development combined with interactive neurodevelopmental games designed to strengthen brain pathways for specific skills, at times when the pathways are particularly sensitive to life experiences, are associated with improvement in parent-child interactions and child problem solving skills. If caregiver education combined with interactive neurodevelopmental games are shown to promote cognitive and social-emotional development in infants undergoing medulloblastoma treatment, there is great potential for reducing cognitive morbidity and improving quality of life for the entire population of young children undergoing cancer therapy.

PI_NAMEs: CONKLIN, HEATHER M (contact)

PROJECT_TERMS: 5 year old;acceptability and feasibility;Age;Agreement;Behavioral;Brain;Brain Neoplasms;brain pathway;cancer diagnosis;cancer therapy;caregiver education;Caregivers;Characteristics;chemotherapy;Child;Child Development;Child Rearing;Childhood Brain Neoplasm;childhood cancer survivor;Clinical;Clinical Trials;Code;Cognition;Cognitive;cognitive ability;cognitive development;cognitive skill;design;Development;Diagnosis;Disease;early life adversity;educational atmosphere;Educational process of instructing;Emotional;empowerment;Enrollment;Failure;Family;Frequencies;Goals;group intervention;Impairment;improved;Incidence;infancy;Infant;interest;Intervention;Knowledge;Late Effects;Life;Life Experience;Literature;Longitudinal Studies;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Medulloblastoma;Morbidity - disease rate;Neurosciences;Outcome;Parent-Child Relations;Parents;Participant;Pathway interactions;Performance;Pilot Projects;Play;Population;post intervention;Problem Solving;programs;psychosocial adjustment;Quality of life;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Records;recruit;Reporting;Research;Research Support;Risk;Risk Factors;satisfaction;Single-Blind Study;skills;social;standard of care;Surveys;Survivors;Telephone;Text;therapy development;Treatment Efficacy;Videotape

PROJECT_TITLE: Caregiver Education with Interactive Neurodevelopmental Games to Improve Cognitive and Social-Emotional Outcomes in Infants Undergoing Treatment for Medulloblastoma

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: SOLNA

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: KAROLINSKA INSTITUTE

PHR: Project Narrative This proposal will systematically characterize the properties and mechanisms underlying the influx pathway of cochlear aqueduct and how age may alter its function in mice. The studies will address key gaps in our understanding of the cochlear aqueduct and will use the most sensitive pre-clinical MRI and laser capture microscopy coupled to single cell sequencing technologies to investigate an unexplored area in auditory research. The results from this project will establish a fundamental basis for understanding the CA as a passage route to and from the cochlea and its use for pre- clinical delivery strategies to treat cochlear disorders.

PI_NAMEs: CANLON, BARBARA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Age;Aging;Animals;Area;Attention;Auditory;awake;Blood Vessels;bone mass;Bypass;CBA/CaJ Mouse;Cell Line;Cells;Cerebrospinal Fluid;Characteristics;clinically relevant;Cochlea;contrast enhanced;Coupled;Development;Disease;Equilibrium;Experimental Designs;experimental study;Future;Gadovist;Goals;Histologic;Histology;Image;Immune;improved;Individual;Inflammatory;Investigation;Knowledge;Label;Labyrinth;laser capture microdissection;Lasers;life span;Liquid substance;Lymphatic System;Lymphoid;Macrophage;Magnetic Resonance Imaging;Maps;Membrane;Microscopy;Microspheres;middle age;Molecular;monocyte;Morphology;Mus;neuroimaging;new technology;next generation sequencing;noise exposure;noise trauma;old mice;pathogen;Pathway interactions;Perilymph;Perilymphatic Duct;Pharmaceutical Preparations;Physiological;pre-clinical;pressure;Process;Property;Reagent;recruit;Research;Resolution;Respiratory Diaphragm;Rodent;Role;Route;single cell sequencing;single-cell RNA sequencing;Sorting;Source;stem cells;Subarachnoid Space;Technology;Testing;Therapeutic;Therapeutic Uses;Tissues;Tracer;transcriptome sequencing;treatment strategy;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Characterization of the cochlear aqueduct

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Systems Genetics of Tuberculosis. Overall program. Project Narrative. Understanding the biological factors that control an individual’s susceptibility to tuberculosis would enable the rational design of more effective interventions. This project will take advantage of new genetic strategies and unique cohorts of diverse human, animal, and bacterial populations to identify the critical factors that determine the outcome of this infection.

PI_NAMEs: SASSETTI, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;analytical method;Animal Model;Animals;bacterial genetics;Biological;Biological Factors;biological heterogeneity;Biological Models;Biology;Cells;chemotherapy;Clinical;clinical phenotype;cohort;Collaborations;combinatorial;Communities;comorbidity;cytokine;Data Set;Diagnostic;Disease;disease phenotype;Disease Progression;disorder risk;effective intervention;Ensure;Environmental Risk Factor;Epidemiology;Exposure to;fitness;Fostering;Funding;Genes;Genetic;genetic approach;Genetic Polymorphism;genetic resource;genetic variant;Genomics;Goals;Heterogeneity;Human;human data;Human Genetics;Immune;Immune response;Immunity;Immunologics;Inbred Strains Mice;Individual;Infection;Inflammatory;insight;Interferon Type II;Intervention;Link;Location;Macrophage;Mammalian Genetics;Metabolic;Mitochondria;Modeling;mouse genetics;mouse model;Mus;Mycobacterium tuberculosis;novel;nutrition;Outcome;pathogen;Pathologic;Pathology;Pathway interactions;Patients;Persons;Peru;Phenotype;Play;Population;preclinical development;Predisposition;Process;programs;Proteins;rational design;Recording of previous events;Research;Resources;response;Risk;Role;Sampling;Signal Transduction;Societies;Structure;success;System;Testing;transmission process;Tuberculosis;tuberculosis immunity;Vaccination;vaccine development;vaccine efficacy;vaccine formulation;Vaccines;Variant

PROJECT_TITLE: Systems Genetics of Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MC-M (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PROJECT_TITLE: Core C Admin Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PROJECT_TERMS: Alleles;Animal Model;Automobile Driving;Biological;causal variant;Chromosome Mapping;Complex;congenic;Custom;Development;Disease;disease model;Disease Outcome;Disease Pathway;efficacious treatment;Engineering;fitness;Funding;Generations;Genes;Genetic;genetic approach;Genetic Polymorphism;genetic resource;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome resource;genome sequencing;Genomic Segment;genomic variation;Genomics;Goals;Haplotypes;Health;Human;human disease;human model;Immune response;Immunity;Immunization;Immunologics;Immunophenotyping;improved;Inbred Strains Mice;Infection;Infection Control;Intervention;Link;Maps;Mediating;model development;Modeling;Molecular;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Mutation;Mycobacterium tuberculosis;new technology;novel;Optics;Outcome;pathogen;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiological;Play;Population;Positioning Attribute;Predisposition;Process;programs;Protein Isoforms;Quantitative Trait Loci;Recording of previous events;Reproducibility;Research Project Grants;Resources;response;Role;segregation;Speed;Structure;Support System;System;transcriptomics;Tuberculosis;Tuberculosis diagnosis;vaccine efficacy;vaccine response;Vaccines;Validation;Variant;Work

PROJECT_TITLE: Core A Mouse Genetics and Genomics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PI_NAMEs: LAUFFENBURGER, DOUGLAS A (contact)

PROJECT_TERMS: Address;Admission activity;animal data;Animals;Bar Codes;behavioral phenotyping;biological information processing;Biological Process;Blood;Blood Cells;Complex;Computer Analysis;Computer Models;Data;Disease;Disease Outcome;Disparate;Exhibits;Feedback;Genetic;Genotype;Heterogeneity;Human;Immune response;Immunity;Immunologics;Individual;Infection;Integration Host Factors;Libraries;Lung;Machine Learning;Macrophage;Measurement;Mediating;Methods;Mitochondria;Modeling;Molecular;Motivation;Mouse Strains;multiple data types;Mus;Mycobacterium tuberculosis;Myelogenous;network models;novel;Outcome;pathogen;Pathway interactions;Persons;Population;Predisposition;programs;Property;Quality Control;Research Personnel;response;single-cell RNA sequencing;Subgroup;success;System;Techniques;Testing;Tissues;transcriptome sequencing;translational model;Tuberculosis;Tuberculosis Vaccines;vaccine strategy;vaccine-induced immunity;Variant

PROJECT_TITLE: Core B Computational Modeling and Analysis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PROJECT_TERMS: Anatomy;Animal Model;Animals;Bar Codes;Biology;Blood;Cell model;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;computer framework;cytokine;Development;Disease;Disease Marker;Disease Progression;DNA;efficacy testing;Engineering;Genes;Genetic;genetic variant;genome wide association study;genome-wide;Goals;Heterogeneity;Human;human data;Immune;Immune response;Immunity;Immunologics;immunoregulation;Immunotherapy;Individual;Infection;Inflammatory;Inflammatory Response;insight;Libraries;Link;Lung;Lung infections;Macrophage;Mediator;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Mus;Mutagenesis;Mycobacterium tuberculosis;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;novel;Outcome;pathogen;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;Population;Predisposition;Process;Production;programs;Progressive Disease;Proteins;Respiration;response;Role;Shapes;Signal Transduction;single cell technology;Site;Source;Stress;success;System;Testing;transcriptomics;Tuberculosis;Variant

PROJECT_TITLE: Project 1 Immunometabolic Determinants of Susceptibility


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Rare Diseases;Tuberculosis;Vaccine Related

PROJECT_TITLE: Project 2 Bacterial determinants of host adaptation and evolutionary success


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PI_NAMEs: BEHAR, SAMUEL M (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Animals;Antitubercular Agents;Attention;Bacille Calmette-Guerin vaccination;Bacteria;BCG Live;Blood;causal variant;Clinical;cohort;Collaborations;Control Locus;cytokine;Data;design;Drug resistant Mycobacteria Tuberculosis;Engineering;Evaluation;Exposure to;Funding;Gene Expression Profile;Gene Pool;Genetic;Genetic Polymorphism;Genetic Transcription;Genetic Variation;genomic locus;Genus Mycobacterium;Goals;Hand;Human;Human Genetics;Immune;immune function;Immune response;Immunity;Immunologics;improved;Inbreeding;Infant;interest;Knowledge;Laboratory mice;Lung;Mammalian Genetics;Measures;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;Nature;novel;novel vaccines;Outcome;Pathway interactions;Persons;Polyproteins;Population;Population Heterogeneity;Pre-Clinical Model;prevent;Production;programs;prospective;Pulmonary Tuberculosis;Quantitative Trait Loci;Reporting;Research;response;Role;Sampling;South Africa;success;System;Testing;Translating;translation to humans;Tuberculosis;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine evaluation;Vaccine Production;vaccine response;vaccine strategy;vaccine trial;vaccine-induced immunity;Vaccines;Variant;vector vaccine;Viral Vector;Work

PROJECT_TITLE: Project 3 Determinants of Vaccine Efficacy


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: There are currently no treatments that reverse disability or repair cortical demyelinating lesions in progressive multiple sclerosis (MS). Cortical microglia respond to demyelination, but it is not well-understood how microglia later contribute to myelin and oligodendrocyte replacement. This proposal will provide a fundamental understanding of the relationship between cortical microglia and oligodendrocytes, that will drive future therapeutic remyelination strategies.

PI_NAMEs: ORTHMANN-MURPHY, JENNIFER LAUREN (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adopted;Adult;antagonist;behavior prediction;Caring;Cell Communication;Cell Count;Cell Lineage;cell type;Cells;Central Nervous System;Chemicals;Cuprizone;Demyelinations;density;differential expression;disability;Disease;Environment;Excision;experimental study;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Gifts;Goals;Grant;gray matter;Heterogeneity;Image;Immune;Impairment;In Situ;in vivo;in vivo imaging;in vivo two-photon imaging;Individual;Ingestion;Injury;innovation;Knowledge;Label;Lesion;Mediating;Microglia;Modeling;Modification;Molecular;Morphology;Motor;Multiple Sclerosis;Multiple Sclerosis Lesions;Mus;Myelin;myelin degeneration;Myelin Sheath;Natural regeneration;new therapeutic target;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Outcome;Pathology;precursor cell;prevent;Process;Recovery;remyelination;repaired;Resolution;response;RNA;Role;single-cell RNA sequencing;Spatial Distribution;Surveys;temporal measurement;Testing;Therapeutic;Time;Tissues;tool;two-photon;Visualization;white matter

PROJECT_TITLE: The role of microglia in cortical remyelination

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Approximately 42,000 Veterans are living with chronic spinal cord injury (SCI) in the United States. SCI often leads to an extremely sedentary lifestyle and marked bone loss that is associated with an increased life-long risk of fractures, morbidity, and financial burden. To date, there is no practical approach to safely and efficaciously treat osteoporosis and bone fractures in Veterans with chronic SCI. This study will test if a novel agent, an antibody against a bone cell receptor (Siglec-15) with unique bone-preserving and bone-building activity, can safely improve skeletal integrity, strength, and fracture healing in a preclinical model of chronic SCI and severe bone loss below the level of lesion. The proposed study will clarify basic mechanisms of novel processes that control bone cell function, thereby improving efforts to reverse SCI-related deterioration of bone. If successful, the proposed treatment can be swiftly deployed in a clinical trial and, ultimately, to clinical care with greater promise to improve skeletal health in Veterans with chronic SCI than that of currently available treatment options.

PI_NAMEs: QIN, WEIPING  (contact)

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Address;Alleles;Amputation;Anabolic Agents;Animal Model;antagonist;Antibodies;Area;Binding;Biological Markers;Blood;blood vessel development;bone;bone cell;bone fracture repair;bone fragility;bone health;bone loss;bone mass;Bone necrosis;bone preservation;Bone Resorption;Caring;Cell Physiology;Cell Surface Receptors;Chest;Chronic;clinical care;Clinical Trials;clinically relevant;Collaborations;Communication;Complex;Contracture;cost;decubitus ulcer;Deep Vein Thrombosis;Defect;Deterioration;Disease;Eligibility Determination;Etiology;exoskeleton;FDA approved;Female;Femoral Fractures;Financial Hardship;Fracture;fracture risk;functional independence;functional outcomes;Future;Gait;Goals;Health;Healthcare;Hip region structure;Hospitalization;Immobilization;Immune system;Immunoglobulins;Impairment;improved;in vivo;Individual;inhibiting antibody;innovation;insight;Intervention;Jaw;Knee;Knockout Mice;Knowledge;Lectin;Lesion;Lifelong disability;Lower Extremity;Macrophage;male;Marketing;Measures;mechanical properties;Mediating;Medical;member;MicroRNAs;Minor;Mission;Modality;Modeling;Molecular;Monoclonal Antibodies;Mononuclear;Morbidity - disease rate;Multiple Sclerosis;Mus;Natural Killer Cells;Nature;Nervous System Disorder;neural circuit;Neurologic;Neurostimulation procedures of spinal cord tissue;novel;novel strategies;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteomyelitis;Osteoporosis;Paralysed;Parkinson Disease;Pathological fracture;Persons;Physiologic Ossification;Polysaccharides;Population;Postmenopausal Osteoporosis;pre-clinical;Pre-Clinical Model;preservation;Prevalence;prevent;Process;Property;Quality of life;Rattus;Receptor Cell;Recovery of Function;Regulation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Residual state;response;Rheumatism;Risk;Rodent Model;Role;Safety;sedentary lifestyle;sialic acid binding Ig-like lectin;Sialic Acids;side effect;skeletal;skeletal preservation;Space Flight;Spinal Cord Contusions;Spinal cord injury;Stress;Stroke;Technology;Testing;Therapeutic;Time;TNFSF11 gene;Torsion;Translating;Trauma;tumor;TYROBP gene;United States;Vascularization;Veterans;Walking;Wistar Rats;Work

PROJECT_TITLE: The Blockade of Siglec-15 as a Novel Approach to Improve Skeletal Integrity and Fracture Healing in Chronic SCI

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ORG_CITY: PITTSBURGH

PHR: All manual lifting and repositioning techniques have a high-risk for injury to caregivers. Work-related back pain and injuries are a widespread epidemic, and due in large part to repeated patient handling activities, including lifting, transferring, and repositioning tasks. Research has shown that mechanical lift technologies reduce the risk of injuries, but people with mobility impairments and caregivers both desire new, powered devices for safer, more comfortable, and independent transfers. The goals of this project are to iteratively design, prototype and test a modified AgileLife Powered Personal Transfer System and a compatible group 3 power wheelchair to allow the ‘no lift’ system to be used independently by wheelchair users.

PI_NAMEs: DUVALL, JONATHAN  (contact)

PROJECT_TERMS: Area;assistive robot;Back Injuries;Back Pain;Beds;career;Caregivers;Characteristics;Clinical;Code;Community Participation;Computer software;Consensus;design;Development;Devices;disability;Disabled Persons;Docking;Epidemic;Equipment;Evaluation;experience;Failure;Floor;Focus Groups;Goals;Grant;Hand;Head;Health;high risk;Home;hospital bed;Hospitals;Immobilization;Impairment;indexing;Individual;Individuals with physical disabilities;Injury;iterative design;Licensing;Lifting;Long-Term Care;Manual wheelchair;Manuals;Marketing;Measures;Mechanics;Medical center;member;Mobility decline;Modification;Movement;Musculoskeletal Diseases;Outcome Measure;Participant;Patient Transfer;Patients;Persons;Phase;Policies;Positioning Attribute;Powered wheelchair;prototype;Quadriplegia;Quality of life;Questionnaires;Research;Risk;Risk Reduction;Robotics;Safety;Scientist;Self-Help Devices;skills;Surveys;System;task analysis;Techniques;Technology;Technology Transfer;Testing;tool;Training;Transcript;Trees;United States National Aeronautics and Space Administration;Upper Extremity;usability;Veterans;Voice;Wheelchair user;Wheelchairs;Work

PROJECT_TITLE: Refinement and Evaluation of Group 3 Powered Personal Transfer System

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


PHR: Compromised hand function due to stroke and spinal cord injury is a leading cause of disability among U.S. Veterans and the broader population. There is growing evidence that pairing stimulation of the vagus nerve with task repetition during rehabilitation can enhance relearning of motor functions compromised by neurological injury. Implantable vagus nerve stimulators require medical procedures that are invasive and costly, but there is evidence to support that the vagus nerve can be accessed with electrical currents applied to different locations on the external ear. Which location to target is not well understood, and the intensity and timing of stimulation needed to achieve therapeutic effects remain unresolved. This project examines whether a noninvasive approach to vagus nerve stimulation enhances motor learning and addresses practical considerations, such as where and how to stimulate.

PI_NAMEs: URBIN, MICHAEL A. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Anatomy;Area;Arousal;associated symptom;Attention;Behavior;Brain;Brain Stem;Caring;Cell Nucleus;chemical release;Clinical;clinical translation;Clinical Trials;cost;Cutaneous;Data;dermatome;Diameter;Digit structure;disability;Disease;Distal;Ear;efficacy testing;Electrodes;Enhancement Technology;External Ear;functional improvement;Funding;Future;grasp;Hand functions;hand rehabilitation;Health;Human;Impairment;Implant;Implantation procedure;improved;indexing;Individual;individual variation;Injury;Investigation;Knowledge;Learning;Life;Limb structure;Location;Maps;Mediating;Medical;Methods;Motor;motor control;motor impairment;motor learning;Muscle;Mydriasis;Nerve;Nerve Fibers;nerve supply;Nervous System;Nervous System Trauma;neural circuit;neural network;neuroregulation;Outcome;Performance;Physiologic pulse;Physiological;Physiology;Placebo Control;placebo group;Population;post stroke;Procedures;Pupil;Randomized;Recovery;recruit;Rehabilitation therapy;Resources;response;Scientific Inquiry;segregation;Site;Skin;Spinal cord injured survivor;Spinal cord injury;Stroke;stroke survivor;Structure;symptom treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Trials;therapy outcome;Time;tool;Training;transcutaneous stimulation;Transdermal substance administration;trend;Up-Regulation;vagus nerve stimulation;Vagus nerve structure;Variant;Veterans;visual motor;Work

PROJECT_TITLE: Transcutaneous Auricular Vagus Nerve Stimulation: Motor Learning & Mechanisms

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: We propose a highly coordinated and synergistic Center that will develop end-to-end approaches and generalizable methods for designing potently protective vaccines against paramyxoviruses and bunyaviruses. Our Center brings together groups with world-leading expertise in computational protein design, structure-based vaccine design, mRNA vaccines, structural biology, viral entry, viral diversity and evolution, animal model development, high biosafety-level containment virology, vaccinology, and vaccine process development and technology transfer. Our Center will generate new knowledge, tools, and generalizable vaccine design approaches that will significantly advance vaccine development for pandemic preparedness generally, and will have a direct impact on public health through the development of antibody and vaccine candidates for several paramyxoviruses and bunyaviruses.

PI_NAMEs: KING, NEIL  (contact);STUART, LYNDA ;VEESLER, DAVID

PROGRAM_OFFICER_NAME: BRIDWELL, ANNE ELIZABETH MAYER

PROJECT_TERMS: Address;Animal Model;animal model development;Animals;Antibodies;Antigens;Arenavirus;Bioinformatics;Biological Assay;Biological Products;Communities;Computing Methodologies;Containment;COVID-19 vaccine;data management;design;Development;Disease Outbreaks;Electron Microscopy;emerging pathogen;Ensure;Epitopes;Evolution;experience;Family;fundamental research;Generations;Glycoproteins;Hendra Virus;Human;Immunize;immunogenic;Industry;innovation;Institution;Knowledge;Lassa virus;Leadership;Learning;Libraries;Licensure;Machine Learning;machine learning method;Medicine;Membrane;Messenger RNA;method development;Methods;model development;Modeling;Monoclonal Antibodies;mRNA delivery;mutation screening;nanoparticle;next generation;novel;novel strategies;Office of Administrative Management;Orthobunyavirus;Output;pandemic potential;pandemic preparedness;Paramyxovirus;pathogen;Pathway interactions;Performance;Phase;preclinical development;Process;product development;Production;Protein Engineering;protein structure prediction;Proteins;prototype;Public Health;receptor;Research;Resolution;Rift Valley fever virus;RNA vaccine;scaffold;self assembly;structural biology;Structure;synergism;Technology;Technology Transfer;Testing;Therapeutic;tool;tool development;vaccine candidate;Vaccine Design;vaccine development;vaccine discovery;vaccine evaluation;vaccine platform;vaccine strategy;vaccine-induced antibodies;Vaccines;vaccinology;Variant;Viral;Viral Antigens;virology;Virus;Work

PROJECT_TITLE: Machine learning-enabled design of prototype pathogen vaccines and antibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (J1)]


PI_NAMEs: STUART, LYNDA  (contact)

PROJECT_TERMS: Agreement;Antibodies;Area;career;cohesion;Collaborations;Communication;Communities;Conflict (Psychology);conflict resolution;Contracts;data management;data sharing;design;Development;Ensure;Event;Evolution;experience;Fostering;Funding;Goals;Government;Human Resources;Immunology;industry partner;Infrastructure;Institution;Intellectual Property;Laboratories;Lead;Leadership;Machine Learning;meetings;member;Monoclonal Antibodies;Orthobunyavirus;Paramyxovirus;pathogen;Persons;Pilot Projects;Process;Productivity;programs;Protein Engineering;prototype;Publications;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Rest;Route;Running;Series;structural biology;success;symposium;Technology Transfer;Training;Training Support;Travel;United States National Institutes of Health;Vaccine Design;vaccine development;Vaccines;Viral;virology;Work

PROJECT_TITLE: Core A: Administrative


PI_NAMEs: GOLDSCHMIDT, LUKI  (contact)

PROJECT_TERMS: Acceleration;Amino Acid Sequence;Antibodies;Archives;Biological Assay;biological research;cluster computing;Code;Collaborations;Computer software;Computer Systems;computerized data processing;Computing Methodologies;computing resources;Cryoelectron Microscopy;Data;data access;Data Collection;data exchange;data integrity;data management;data preservation;data sharing;deep sequencing;design;Ensure;Environment;Equilibrium;Event;FAIR principles;flexibility;Fostering;Goals;High Performance Computing;High-Throughput Nucleotide Sequencing;Image;in silico;Industry Standard;Information Systems;Institution;Life;Machine Learning;Maintenance;member;Methods;microscopic imaging;model design;Monitor;Negative Staining;Notification;open source;pathogen;Performance;Policy Making;Positioning Attribute;prevent;Process;Protein Engineering;protein structure;Proteins;Protocols documentation;prototype;Recovery;repository;Reproducibility;Research;Resources;Rest;Running;Scientific Advances and Accomplishments;Secure;Security;Site;success;System;Time;tool;Training;United States National Institutes of Health;Vaccines;Work;Workload;X ray diffraction analysis

PROJECT_TITLE: Core B: Data Management


PI_NAMEs: CARTER, LAUREN  (contact)

PROJECT_TERMS: Acceleration;analytical method;Antibodies;Antigens;Arenavirus;B-Lymphocytes;Benchmarking;betacoronavirus;Biological Assay;Biological Products;Biological Sciences;Cell Separation;clinical development;Clinical Trials;Collaborations;cost;Country;COVID-19 vaccine;Cyclic GMP;Data;Dedications;design;Development;Disease Outbreaks;Documentation;Equipment;Evaluation;Event;experience;experimental study;flexibility;Formulation;Foundations;Funding;Goals;Government;HIV-1;Human Resources;immunogenicity;In Vitro;in vivo;Industry;industry partner;Influenza;Infrastructure;innovation;Institution;Laboratories;Laboratory Research;Lead;Licensing;lipid nanoparticle;Machine Learning;manufacture;Medicine;Messenger RNA;method development;Methods;Monoclonal Antibodies;mutation screening;nanoparticle;National Institute of Allergy and Infectious Disease;Nucleosides;paramyxovirus vaccine;pathogen;preclinical development;Process;product development;Production;Protein Engineering;protein purification;Proteins;prototype;Reagent;receptor;Records;Reference Standards;Research Support;RNA vaccine;SARS coronavirus;Scientist;Serology;Speed;Standardization;structural biology;Technology Transfer;Testing;Therapeutic;Translating;Translations;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Production;Vaccines;Viral;Work

PROJECT_TITLE: Core C: Vaccine production and process development


PI_NAMEs: GEISBERT, THOMAS WILLIAM (contact)

PROJECT_TERMS: Advanced Development;Animal Husbandry;Animal Model;animal tissue;Animals;Antibodies;Antibody Response;Antibody Therapy;Arenavirus;Autopsy;Biological Assay;Blood specimen;Bunyavirales;Bunyaviridae;Case Fatality Rates;Cells;Clinical;Clinical Chemistry;Clinical Pathology;combat;Containment;Data;data management;design;Development;Disease;Disease Outbreaks;Endotoxins;Epidemic;Equipment;experience;Family;Genomics;Genus Phlebovirus;Ghana;Goals;Hematology;Hemorrhage;Hendra Virus;Henipavirus;Housing;Human;Human Resources;IACUC;Immune response;Immunologics;Immunology;In Vitro;in vitro Assay;Junin virus;Laboratories;Lassa virus;Laws;Machine Learning;medical countermeasure;Modeling;Monitor;Monoclonal Antibodies;Mycoplasma;National Institute of Allergy and Infectious Disease;Neutralization Tests;neutralizing antibody;novel vaccines;pandemic preparedness;Paramyxovirus;pathogen;Pathologic;Pathology;Periodicals;Plaque Assay;priority pathogen;Protocols documentation;prototype;Public Health;Recording of previous events;Records;Reporter;repository;Research Personnel;Research Project Grants;Resources;Reverse Transcriptase Polymerase Chain Reaction;Rift Valley fever virus;sample collection;Sampling;Scientific Evaluation;Secure;Services;Severe Fever with Thrombocytopenia Syndrome Virus;sterility testing;System;Technical Expertise;Testing;Therapeutic;Tissue Sample;Tissues;tool;Training;Vaccination;vaccine efficacy;vaccine evaluation;vaccine response;vaccine-induced antibodies;Vaccines;Viral;Viral Load result;Viral Physiology;virology;Virus;Work;World Health Organization;Zoonoses

PROJECT_TITLE: Core D: Animal models and vaccine evaluation


PI_NAMEs: BLOOM, JESSE D (contact)

PROJECT_TERMS: Amino Acids;animal model development;Antibodies;Antibody Response;Antigens;Biological Assay;Catalogs;Cell Culture Techniques;Cells;Computational Technique;Data;design;Epitopes;Family;Future;Glycoproteins;Libraries;Machine Learning;Maps;Measurement;Measures;Mediating;model development;Monoclonal Antibodies;mutant;Mutation;mutation screening;neutralizing antibody;novel;pathogen;Phylogenetic Analysis;polyclonal antibody;Property;protein structure;Proteins;prototype;receptor;Resources;response;Serum;Specificity;Structure;success;System;Testing;tool;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Variant;Viral;Virion;Virus;Virus Integration;Visualization;Work

PROJECT_TITLE: Core E: Phylogenetic and mutational scanning


PI_NAMEs: BAKER, DAVID  (contact)

PROJECT_TERMS: Algorithm Design;Amino Acid Sequence;Amino Acids;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;Area;biological research;Collaborations;Communities;Complex;Computer software;Computing Methodologies;Cryoelectron Microscopy;Data;Data Set;density;design;Diffusion;Dimensions;Electron Microscopy;Epitopes;Experimental Designs;Family;flexibility;Foundations;Generations;Glycoproteins;glycosylation;Goals;Heterogeneity;Immunology;improved;Infection;innovation;Knowledge;Link;Machine Learning;machine learning algorithm;machine learning method;Maps;Methods;Modeling;Molecular Conformation;Monoclonal Antibodies;Mutation;mutation screening;nanoparticle;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel strategies;open source;Paper;pathogen;polyclonal antibody;Post-Translational Protein Processing;protein complex;Protein Conformation;Protein Engineering;protein structure prediction;Proteins;prototype;Publishing;receptor;Research;Resolution;Sampling;scaffold;Science;self assembly;shot learning;Speed;structural biology;structural determinants;Structure;synergism;Techniques;tool;Training;Vaccine Design;Vaccines;Vertebral column;Viral;Viral Antigens

PROJECT_TITLE: Project 1: Computational methods


PI_NAMEs: VEESLER, DAVID  (contact)

PROJECT_TERMS: Amino Acids;Animals;Antibodies;Antibody Response;Antigens;Architecture;Biological Assay;Cells;Collaborations;Complex;Coronavirus;Coronavirus Infections;COVID-19 pandemic;COVID-19 vaccine;design;Development;Electron Microscopy;Epitope Mapping;Evaluation;Genome;Glycoproteins;Henipavirus;Human;Humoral Immunities;Immunity;Immunologics;In Vitro;in vitro Assay;in vivo;Infection;Knock-out;Knowledge;Lead;Machine Learning;Maps;Mediating;Membrane Glycoproteins;Memory B-Lymphocyte;Methods;Modeling;Molecular;Monoclonal Antibodies;Mutation;mutation screening;neutralizing antibody;neutralizing monoclonal antibodies;next generation;pathogen;Peptide Hydrolases;permissiveness;Phylogenetic Analysis;polyclonal antibody;portability;prospective;protective efficacy;prototype;receptor;Resolution;Role;SARS-CoV-2 immunity;Serology;Site;South Korea;structural biology;Structure;Time;tissue tropism;Tissues;Transfection;Tropism;United Kingdom;Vaccinated;Vaccine Design;Vaccines;Validation;Viral;viral entry inhibitor;Virus;Work

PROJECT_TITLE: Project 2: Viral entry, antibodies, and structural biology


PI_NAMEs: KING, NEIL  (contact)

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antibody Response;Antigens;Arenavirus;Base Sequence;Binding Proteins;Biochemical;Biophysics;Cancer Center;Chimeric Proteins;Collaborations;Complex;Computing Methodologies;Cryoelectron Microscopy;design;Disease Outbreaks;Evaluation;Family;Feedback;Generations;glycoprotein structure;Glycoproteins;Goals;Hendra Virus;Immunize;immunogenic;immunogenicity;Immunologics;improved;in vivo;Infrastructure;inhibiting antibody;innovation;Lassa virus;lead candidate;Length;Machine Learning;machine learning method;Maps;Measurement;Membrane;Messenger RNA;Methods;Modeling;Molecular Conformation;monomer;Mus;Mutation;mutation screening;nanoparticle;neutralizing antibody;novel;Orthobunyavirus;Paramyxovirus;Paramyxovirus Fusion Protein;pathogen;Performance;preservation;Production;Protein Engineering;Proteins;prototype;receptor;receptor binding;Resolution;response;Rift Valley fever virus;screening;Serology;Structure;thermostability;vaccine candidate;Vaccines;Variant;Vertebral column;Viral;virology;Virus;X-Ray Crystallography

PROJECT_TITLE: Project 3: Antigen design


PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Antibodies;Antibody Response;Antigen Presentation;Antigens;Arenavirus;Binding Proteins;Biochemical;Biophysics;Cancer Center;candidate selection;Chimeric Proteins;Clinical;clinical development;Clinical Trials;Complex;Computing Methodologies;Coupled;COVID-19 vaccine;design;Development;Epitopes;Evaluation;Exercise;Family;Feedback;Fire - disasters;Freedom;Geometry;Glycoproteins;Goals;HIV;immunogenic;immunogenicity;improved;In Vitro;Influenza;Infrastructure;lead candidate;Leadership;Learning;Licensing;Machine Learning;machine learning method;manufacturability;Messenger RNA;Methods;Modeling;monomer;mutation screening;nanoparticle;neutralizing antibody;Orthobunyavirus;Paramyxovirus;paramyxovirus vaccine;pathogen;Performance;Positioning Attribute;preclinical development;preclinical evaluation;Production;Productivity;Property;Protein Engineering;Proteins;prototype;Rapid screening;receptor binding;Respiratory Syncytial Virus Vaccines;Series;structural determinants;technology platform;tool;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Viral;Virus;Work

PROJECT_TITLE: Project 4: Protein nanoparticle vaccines


PROJECT_TERMS: Antibodies;Antigens;Arenavirus;Blood group antigen f;Cell surface;Cells;computerized tools;Computing Methodologies;design;Development;Diffusion;Disease Outbreaks;Epitopes;Evaluation;Exercise;experience;Family;Family member;Fire - disasters;Goals;immunogenicity;improved;in vivo;Industry;Leadership;Machine Learning;machine learning method;manufacture;Mediating;member;Membrane;Messenger RNA;Molecular Conformation;monomer;mRNA delivery;nanoparticle;Orthobunyavirus;Paramyxovirus;paramyxovirus vaccine;pathogen;Peptide Signal Sequences;Performance;Positioning Attribute;Protein Engineering;Proteins;prototype;response;RNA vaccine;Speed;Structure;Technology;Testing;Vaccine Design;vaccine platform;Vaccines;Viral;Virus;Work

PROJECT_TITLE: Project 5: mRNA and mRNA-launched nanoparticle vaccines


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Injury to axons in the central and peripheral nervous systems can have devastating consequences, often resulting in paralysis due to limited axon regeneration. Glia are critical for promoting axon regeneration – creating a permissive environment by clearing axonal and glial debris or inhibiting regeneration by releasing debris into the environment – but the mechanisms of glial adaptation to the stress of axon injury are unclear. In this proposal, I will identify the molecular and cellular basis of a novel glial recovery response to axon injury and its necessity in promotion of subsequent axon regeneration.

PI_NAMEs: RASHID, ALINA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acceleration;acid sphingomyelinase;Advisory Committees;Affect;Afferent Neurons;American;Animals;Antibodies;Automobile Driving;Autophagocytosis;Axon;axon injury;axon regeneration;Axotomy;Biological Assay;Caenorhabditis elegans;Cardiac Myocytes;CASP3 gene;CASP7 gene;Caspase;Cells;Cellular biology;Central Nervous System;Ceramides;Characteristics;Data;Detection;Electron Microscopy;Environment;Excision;Exhibits;experience;experimental study;fly;Future;Genetic;Growth;Human;Image;improved;Injury;knock-down;Label;Larva;Mass Spectrum Analysis;Measures;Mediating;Membrane;Mentors;meter;Methods;Mission;Mitochondria;Modeling;Molecular;Mus;mutant;National Institute of Neurological Disorders and Stroke;Natural regeneration;Neuroglia;Neurons;neurotransmission;novel;Oxidative Stress;Paralysed;Pathway interactions;Pediatric Hospitals;Pennsylvania;Peripheral Nervous System;permissiveness;Phenotype;Philadelphia;Phospholipids;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Production;Recovery;repaired;Reporter;Research;Research Personnel;Resources;response;RNA Interference;Role;Sensory;Signal Transduction;Site;Sphingomyelins;Spinal Cord;Stains;Stress;System;Technical Expertise;Testing;Universities;Up-Regulation;Vesicle;vesicular release;Work;wound healing

PROJECT_TITLE: Mechanisms of glial detection of axonal injury and facilitation of axonal regeneration

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: The that microenvironment strategies for is NARRATIVE proposed research is relevant to public health because i t focuses on defining new and alternative strategies simultaneously monitor and effect efficacious biological modulation within the hypoxic i mmunosuppressive that is responsible for the growth and urvival of primary malignant brain tumors. Once such have been developed, there is the potential for a significant advance in anti-cancer immunotherapies  patients with the most aggressive and deadly form of brain cancer; glioblastoma. Thus, the proposed research relevant to the part of the NIH's mission that pertains to reducing illness and disability. PROJECT s

PI_NAMEs: BARAJAS, RAMON FRANCISCO (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Acceleration;Address;Adult;angiogenesis;Astrocytes;Biological;Biological Monitoring;Biology;Blood Vessels;Brain;Brain Neoplasms;cancer immunotherapy;cancer therapy;cancer type;Cell Proliferation;checkpoint therapy;chemoradiation;Clinical;clinical development;clinical efficacy;Clinical Treatment;Clinical Trials;cohort;cytotoxic;cytotoxicity;Data;Development;Diagnosis;Diagnostic;diagnostic value;disability;Early Intervention;evidence base;Failure;FDA approved;ferumoxytol;functional status;Future;Gadolinium;Glioblastoma;Goals;Growth;Human;Hypoxia;Image;Imaging technology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;innovation;Iron;Knowledge;Legal patent;Link;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Methodology;Methods;Microglia;Mission;Modeling;Monitor;nanoparticle;neuroinflammation;neurovascular unit;Newly Diagnosed;non-invasive monitor;novel;novel imaging technology;off-label use;Operative Surgical Procedures;Outcome;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phase II Clinical Trials;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;prognostic performance;prospective;Public Health;Research;Resistance;Resistance development;Rodent;Rodent Model;Schedule;segregation;standard care;standard of care;Techniques;temozolomide;Testing;Therapeutic;therapeutic development;therapeutic target;Time;tool;Treatment Efficacy;Treatment outcome;tumor;Tumor Escape;tumor hypoxia;Tumor-associated macrophages;tumor-immune system interactions;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Leveraging Biologically Specific PET/MRI Monitoring and Therapeutic Modulation of the Hypoxic Glioblastoma Tumor Immune Microenvironment into Improved Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J1)]


NIH_SPENDING_CATS: Cachexia;Cancer

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Interest in understanding and treating cachexia has intensified due to its high mortality rate in cancer patients. Thus, interventions that can improve or preserve muscle mass and function can substantially benefit the health of cachectic individuals. The proposed studies will lead to the understanding of the immune mechanisms driving the loss of skeletal muscle mass and function.

PI_NAMEs: VELAZQUEZ, KANDY T (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Adoptive Transfer;Anti-Inflammatory Agents;ApcMin/+ mice;Automobile Driving;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;carcinogenesis;Cessation of life;Chronic;Chronic Disease;Clinical;Complex;cost;Data;Death Rate;Development;Dichloromethylene Diphosphonate;Dietary Intervention;effective therapy;Exhibits;experience;Fatty acid glycerol esters;Fibrosis;Future;Goals;Health Benefit;Histopathology;Human;Immune;Immunophenotyping;Impairment;improved;Individual;Inflammation;innovation;interest;Intervention;Knockout Mice;Link;Liposomes;Macrophage;Macrophage Activation;malignant muscle neoplasm;Malignant Neoplasms;Medical Care Costs;Metabolic syndrome;mortality;mortality risk;Mus;Muscle;muscle form;Muscle function;Muscular Atrophy;Muscular Dystrophies;muscular structure;novel;novel therapeutics;Organ;Outcome;Outcome Study;overexpression;pancreatic cancer patients;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Play;Pre-Clinical Model;preservation;Protein Isoforms;Quality of life;Rattus;receptor;recruit;reduced muscle mass;Research;Role;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Testing;therapy design;Tissues;Transforming Growth Factor beta;Transforming Growth Factors;Translational Research;treatment strategy;tumor;Tumor Burden;Up-Regulation;Wasting Syndrome

PROJECT_TITLE: The Role of TGFβ2 and Macrophages in Cancer Cachexia


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The goal of the proposed United States Zimbabwe Research Ethics Training Program (US-Zim RETP) is to develop the capacity for research ethics education, training, and ethics research in Zimbabwe. The US-Zim RETP is proposed as an innovative and sustainable Research Ethics Education training program. The program aims to enhance the pedagogical and curricular strengths of key University of Zimbabwe Faculty of Medicine and Health Sciences (UZFMHS) to deliver research ethics courses and mentoring in Zimbabwe; develop and implement a 2 year Master’s level degree in research ethics at the UZFMHS; and to promote key priorities around research ethics in Zimbabwe.

PI_NAMEs: CHIDZONGA, MIDION MAPFUMO;HYDER, ADNAN A (contact);NDEBELE, PAUL

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: academic program;Address;Adoption;Africa;Area;Belief;burden of illness;cohort;Collaborations;Communicable Diseases;Country;cultural values;Decision Making;Degree program;design;Development;Disease;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Environment;Ethical Issues;Ethics;evidence base;experience;Faculty;Future;Generations;Goals;Grant;Guidelines;Health;Health Policy;Health Professional;health science research support;Health Sciences;Health Services;Health system;improved;innovation;Institution;Instruction;International;Learning;learning materials;life span;Master of Science;Medicine;Mentors;Mentorship;model development;Program Development;programs;Public Health Schools;rat Ran 2 protein;recruit;Research;Research Ethics;Research Ethics Committees;Research Priority;Research Project Grants;Research Training;Review Committee;Risk Factors;Running;skills;Students;summer institute;Teacher Professional Development;Testing;Training;Training and Education;Training Programs;United States;Universities;Visit;Washington;Work;Writing;Zimbabwe

PROJECT_TITLE: US-Zimbabwe Research Ethics Training Program (US-Zim RETP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-E (50)]


ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: Veterans are most likely to disclose suicidal thoughts to their close supports such as family and friends. These loved ones are, in turn, very interested in learning how to help a Veteran in need. Close supports are uniquely poised to provide a meaningful contribution to suicide prevention, if they can learn how to effectively promote Veterans' connection to care. VA S.A.V.E. (Signs; Ask; Validate; Encourage and Expedite) is a suicide prevention gatekeeper training specifically tailored to the Veteran community that teaches close supports how to identify signs of suicide risk and how to connect the at-risk person to professional treatment. The primary objective of this study is to evaluate the effectiveness of VA S.A.V.E. and to explore factors impacting its potential widespread implementation.

PI_NAMEs: TEO, ALAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;arm;Behavior;Benchmarking;Black, Indigenous, People of Color;Caregivers;Caring;Clinical;Communities;comparison control;Conduct Clinical Trials;Continuing Education;Data;design;digital;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness trial;Employee;Evaluation;experience;Family;family support;Feeling suicidal;follow-up;Friends;Funding;future implementation;Gatekeeping;help-seeking behavior;Hotlines;hybrid type 2 trial;implementation facilitators;implementation framework;implementation outcomes;innovation;interest;Intervention;Interview;Knowledge;Learning;loved ones;Low income;Measures;Media Campaign;Mediating;Mediator;Methodology;Methods;operation;outreach;Participant;Patient Simulation;peer;Persons;pilot trial;Populations at Risk;prevent;Prevention strategy;primary outcome;Proctor framework;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;response;Risk;Sampling;satisfaction;Self Efficacy;skills;skills training;social media;Standardization;Subgroup;suicidal behavior;suicidal risk;Suicide;suicide model;Suicide prevention;Surveys;systematic review;Target Populations;Testing;Training;treatment arm;treatment response;usability;Veterans

PROJECT_TITLE: Randomized Controlled Effectiveness Trial of VA S.A.V.E. Suicide Prevention Gatekeeper Training for Veterans’ Close Supports

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]