NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_DEPT: MISCELLANEOUS

PHR: Eliminating injury-related fear in patients after ACL reconstruction can decrease the healthcare burden associated with ACL reinjury rates by allowing patients to safely return to physical activity, improve their overall health and wellness, and decrease the risk for the development of overuse conditions like post-traumatic knee osteoarthritis. Relevant to the NIH mission, virtual reality mindfulness meditation may incite a paradigm shift in current treatment strategies, by promoting patient-centered holistic healthcare, for the hundreds of thousands of individuals who sustain an ACL injury and undergo ACL reconstruction.

PI_NAMEs: BAEZ, SHELBY  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Anxiety;Applications Grants;Attention;Auditory;Biological Factors;Biomechanics;Brain;Brain region;career;career development;chronic musculoskeletal pain;chronic pain patient;Complex;Data;Data Analyses;Data Collection;Development;efficacy evaluation;emotion regulation;Exhibits;experience;flexibility;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Grant;group intervention;Health;Healthcare;healthcare burden;Holistic Health;Imagination;improved;Incidence;Individual;Injury;innovation;Intervention;Knee;Knee Osteoarthritis;Knowledge;Learning;Literature;Measures;Mental Depression;mental practice;Methods;Mind;mindfulness;mindfulness meditation;Mission;Motion;Movement;muscle strength;neuroimaging;Neurological outcome;neuromuscular training;novel;Outcome;Pain;patient oriented;Patient Self-Report;Patients;Pattern;Physical activity;placebo group;Population;Positioning Attribute;psychologic;Psychological Factors;Quality of life;Questionnaires;Randomized;Real-Time Systems;Recording of previous events;Rehabilitation therapy;Reporting;Research Personnel;return to sport;Risk;Scientist;Series;Sex Differences;skills;Sports;Surrogate Endpoint;Techniques;Testing;Time;Training;Training Programs;Treatment Efficacy;treatment strategy;United States National Institutes of Health;virtual reality;Visual;Woman;Work

PROJECT_TITLE: Virtual Reality Mindfulness Meditation in Patients after Anterior Cruciate Ligament Reconstruction

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: COLLEGES OF PODIATRIC MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Disability Research;Wound Healing and Care

ORG_CITY: NORTH CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_FIPS: US

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diabetic foot disease represents the costliest of diabetes complications with fiscal as well as personal costs driven by the difficulty of healing diabetic foot ulcers, with non-healing ulcers frequently prompting lower ex- tremity amputations. In contrast to the current practice of trying to predict how specialized footwear will ‘treat diabetic foot ulcers’ in the absence of considering the patient, this project will assess how offloading devices ‘treat people with diabetic foot ulcers’ by looking at how variations in footwear design influence patients’ func- tional experience with them, and in turn adherence and healing. The proposed research is relevant to NIH’s mission because it identifies causes for poor healing of diabetic foot ulcers and potential means of improving their treatment; it is relevant to public health by offering means to reduce the fiscal and personal costs asso- ciated with poor healing of diabetic foot ulcers while improving quality of life for patients during wound healing.

PI_NAMEs: CREWS, RYAN ;ROSENBLATT, NOAH  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Accelerometer;Address;Adherence;Amputation;Ankle;Area;Behavioral;biomechanical test;Biomechanics;chronic ulcer;Clinical Trials;Complications of Diabetes Mellitus;Contralateral;cost;Data;design;Development;Device Designs;Devices;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Diabetic Neuropathies;Disease;Equilibrium;experience;falls;fear of falling;follow-up;foot;Foot Diseases;Future;Gait;Goals;Guidelines;healing;improved;Individual;innovation;Interview;Kinetics;Knee;Lifting;Link;Literature;Lower Extremity;Measurement;Measures;Mediating;Medical Care Costs;Mental Depression;Methods;Mission;Monitor;Motion;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Participant;patient oriented;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pilot Projects;predictive modeling;pressure;Process;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Sample Size;satisfaction;Self Efficacy;Series;Shoes;standard of care;Stress;Surveys;Testing;tissue stress;Uncertainty;United States National Institutes of Health;usability;Variant;walker;Walking;Weight-Bearing state;Work;wound;wound healing

PROJECT_TITLE: Improving Diabetic Foot Ulcer Offloading: A Pilot Study on the Impact of Removable Cast Walker Design Factors on Usability

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Although Δ9-tetrahydrocannabinol (THC) in marijuana provides some medical benefits, researchers need to explore mechanisms that are selective to avoid side effects. This project investigates mechanisms of CB1 cannabinoid receptor regulation by Cannabinoid Receptor Interacting Protein1a (CRIP1a), a protein that targets CB1 receptors in brain cells that express both proteins. Our elucidation of the unique mechanisms used by CRIP1a can offer new insights into human diseases involving neurodevelopment, vision and auditory function, epileptic seizures, and mental health.

PI_NAMEs: HOWLETT, ALLYN C (contact);LOWTHER, W TODD

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 2-arachidonylglycerol;addiction;Adolescent;ADP ribosylation;Agonist;Amino Acid Sequence;Amino Acids;antagonist;Attenuated;Auditory;beta barrel;Binding;Biological Assay;Brain;brain cell;C-terminal;Calcium Channel;cannabinoid receptor;cannabinoid receptor interacting protein 1a;Carrier Proteins;Cell Fractionation;Cell membrane;Cell model;Cell Physiology;Cells;CNR1 gene;Co-Immunoprecipitations;Complex;Crystallization;Cytosol;dimer;Disease;DNA Ligation;Epilepsy;Ethers;experimental study;Family;fetal;Fluorescence Polarization;Functional disorder;Future;Gel;genetic regulatory protein;GTP-Binding Proteins;Health;Homologous Gene;Human;human disease;human model;Hydrophobicity;In Vitro;in vivo Model;insight;Investigation;Knowledge;Length;Ligation;Lipids;Location;Marijuana;Mediating;Medical;Membrane;Mental Health;methanandamide;Modeling;Molecular;Monitor;Monomeric GTP-Binding Proteins;Mutation;Myristates;myristoylation;N-Myristoylation;N-terminal;neuroblastoma cell;Neurodegenerative Disorders;neurodevelopment;neuron development;Neurons;neuroprotection;neurotransmitter release;novel;Pain;Palmitates;palmitoylation;Pathway interactions;Peptide Receptor;Peptides;Pertussis Toxin;Pharmaceutical Preparations;pharmacologic;Phosphorylation;presynaptic;prevent;Process;Property;protein activation;protein aminoacid sequence;Protein Dephosphorylation;Protein Farnesylation;Proteins;Receptor Activation;Receptor Signaling;Recombinant Proteins;Recombinants;Regulation;Research Personnel;Resolution;response;Roentgen Rays;Role;Scanning;Secure;Seizures;Seminal;Sensory;side effect;Signal Transduction;Site;Specificity;SR141716;Structure;Surface;Synaptic Membranes;Testing;Tetrahydrocannabinol;Vision;voltage;X-Ray Crystallography

PROJECT_TITLE: Cannabinoid Receptors and Associated Proteins-Renewal

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a progressive neurological disorder that adversely affects cognition and daily functioning in older adults. This proposal seeks to better understand the association between alterations in dynamic functional brain activity as it relates to biomarkers and decreasing cognition in individuals with mild cognitive impairment and Alzheimer’s disease, as well as cognitively intact seniors. This project will inform clinical trials by predicting biomarker status based on dynamic functional connectivity in older adults with and without cognitive impairment.

PI_NAMEs: KING, JACE BRADFORD (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid;Amyloid deposition;apolipoprotein E-4;Area;Award;behavioral phenotyping;Biological;Biological Markers;Brain;brain abnormalities;career;career development;Classification;Clinical;Clinical Trials;Cognition;Cognitive;cognitive testing;daily functioning;Data;Data Analyses;Data Set;Dedications;Dementia;design;Diagnosis;Diagnostic;Disease;Early identification;effective therapy;Enrollment;Evolution;experience;flexibility;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Healthcare;hippocampal atrophy;Hippocampus;Impaired cognition;improved;Individual;insight;International;Intervention;Intuition;Investigation;Knowledge;Lead;Literature;Longitudinal Studies;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;Monitor;multidisciplinary;multimodality;Nervous System Disorder;neural circuit;Neurobiology;neuroimaging;neuroimaging marker;neuromechanism;Neuropsychological Tests;Neuropsychology;normal aging;novel;older adult;Participant;pathological aging;Patients;Performance;Population;Predictive Factor;predictive marker;Prevention;Prognosis;Research;Research Design;Research Personnel;response to brain injury;Rest;Scanning;skills;Statistical Methods;Statistical Models;statistics;Technology;Testing;Time;tool;Training;Training Programs;Treatment Efficacy;Universities;Utah

PROJECT_TITLE: Novel metrics of brain dynamics in Alzheimer’s disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Brain-targeted combination therapy has the potential to treat medulloblastoma (MB) efficiently. However, multiple drug use often produces toxicity and result in significant neurocognitive deficits. We propose RVG peptide decorated lipid nanoparticles for co-delivery of potent BRD4/PI3K and MDM2/XIAP dual inhibitors.

PI_NAMEs: MAHATO, RAM I. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Abbreviations;analog;anti-cancer;Apoptosis;Apoptosis Inhibitor;Binding;Biodistribution;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;Brain Neoplasms;BRD2 gene;cancer stem cell;Cell Cycle;cell growth;cell killing;Cell Line;Cell Proliferation;Cells;Cerebellum;Chemoresistance;chemotherapy;Childhood Brain Neoplasm;Cholesterol;Clinical;Combined Modality Therapy;Complex;Cyclin D1;Data;design;Development;Dioxins;Dose;Drug Transport;efficacy evaluation;Encapsulated;Erinaceidae;Escherichia coli;Exhibits;Film;Goals;Growth;Human;Hydration status;Hydrophobicity;Impairment;In Vitro;in vitro activity;in vivo;Individual;inhibitor;inhibitor-of-apoptosis protein;innovation;lipid nanoparticle;Lipids;MB03;MDM2 gene;Medulloblastoma;medulloblastoma cell line;meter;migration;mouse model;multiple drug use;mutant;Mutate;Mutation;MYC gene;MYCN gene;N-Myc Protein;Names;nanomedicine;Neoplasm Metastasis;neoplastic cell;nerve stem cell;Neurocognitive Deficit;Neurons;neurotoxicity;novel;Organ;Outcome;Parents;Particle Size;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;phosphoethanolamine;Phosphorylcholine;PIK3CG gene;Plasmids;Play;Polyethylene Glycols;Proliferating;protein purification;Proteins;Proto-Oncogene Proteins c-akt;rabies virus glycoprotein G;Recombinant Proteins;Recombinants;Resistance;Roentgen Rays;Role;Series;SHH gene;Signal Pathway;Signal Transduction;small molecule;smoothened signaling pathway;stem cell proliferation;stem cells;Structure;Surface;synergism;systemic toxicity;technology platform;Toxic effect;TP53 gene;Transgenic Organisms;Treatment Efficacy;treatment strategy;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;wound healing;x-linked inhibitor of apoptosis protein;X-Ray Crystallography

PROJECT_TITLE: Lipid nanomedicine targeting multiple signaling pathways of medulloblastoma

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Chronic stress plays a role in multiple neuropsychiatric disorders, many of which lack highly efficacious treatments. Recently, a single dose of the psychedelic drug psilocybin has been shown to promote long-lasting therapeutic effects in humans, but the underlying mechanisms remain poorly understood. Here, we elucidate the rules governing psilocybin’s repair of specific neural circuits in chronically stressed rodents, with the potential to allow for the design of even more precise and efficacious neuropsychiatric therapies with minimal off-target effects.

PI_NAMEs: AHMED, OMAR JAMIL (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Address;antagonist;Atrophic;awake;Brain;Brain region;cell type;Chronic;Chronic stress;Claustral structure;cognitive reappraisal;Coupling;Dendritic Spines;density;design;Dose;efficacious treatment;Electrodes;Electrophysiology (science);emotion regulation;Excitatory Synapse;Exhibits;Functional impairment;Genes;Glutamates;Growth;Hallucinogens;hippocampal pyramidal neuron;Human;Impairment;in vivo;Investigation;Ketamine;Knock-out;Knowledge;Maps;Modification;Morphology;Mus;neural circuit;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuropsychiatry;neurotransmission;optogenetics;Patients;Pharmacological Treatment;Physiological;Physiology;Play;Population;postsynaptic;Prefrontal Cortex;presynaptic;Property;Psilocybin;Pyramidal Cells;receptor expression;repaired;Rodent;Role;Serotonin;Serotonin Receptor 5-HT2A;Sleep;Specificity;Stress;stress related disorder;Structure;Synapses;Thalamic structure;Therapeutic;Therapeutic Effect;transcriptomics;transmission process;treatment response;Vertebral column

PROJECT_TITLE: Circuit Mechanisms of Psilocybin Following Chronic Stress

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: STATE COLLEGE OF OPTOMETRY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Amblyopia is the second most common cause of vision problems in children, and distortions in perceived forms which can negatively impact life as an adult if uncorrected have been documented but nor understood. We propose to show with experiments and a computational model that the defective perception of shapes is due to problems in the development of oriented cortical cells caused by an imbalance between the signals for lights and darks reaching the cortex due to defocus or misalignment of the amblyopic eye. We will investigate whether orientation processing deficits hinder amblyopes in seeing 3D shapes, poses and symmetry which are conveyed by orientations in the retinal image, with a view to identifying top-down signals that could reactivate plasticity in targeted cells of the primary visual cortex in future therapies.

PI_NAMEs: ZAIDI, QASIM  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Orientation Processing Deficits in Amblyopia: Neural Bases to Functional Implications

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE The medial prefrontal cortex (mPFC) makes essential contributions to learning, mood, and decision making, including evaluating and responding to threats. Compared to other circuits, mPFC circuits undergo prolonged maturation that is likely necessary in order to support complex behaviors but also extends the developmental window during which insults, such as early life adversity, can perturb healthy circuit assembly. The broad goal of this proposal is to establish causal links between mPFC circuit development and the maturation of learned threat avoidance, and to determine how ELA impacts this developmental trajectory.

PI_NAMEs: DENARDO, LAURA ANNE (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Address;Adolescence;Adolescent;Adult;Age;age difference;age related;age related changes;Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;avoidance behavior;Avoidance Learning;Beds;Behavior;Behavioral;Behavioral Assay;Caregivers;Chronic;Cognitive;Companions;Complex;Cues;Decision Making;design;Development;Disease;early experience;early life adversity;effective intervention;Emotional;emotional behavior;Event;Exposure to;Fiber;Functional disorder;Goals;Image;improved;in vivo;in vivo evaluation;Individual;innovation;insight;Intervention;Knowledge;Learning;Link;Medial;Mediating;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;Moods;National Institute of Mental Health;neural;Nucleus Accumbens;optogenetics;Pathway interactions;Pattern;personalized approach;Photometry;Pilot Projects;Prefrontal Cortex;premature;prevent;Research;response;Risk;Risk Factors;Role;Stimulus;Stress;Symptoms;Testing;therapeutic target;Time;tool;Viral;virus genetics

PROJECT_TITLE: Prefrontal circuits underlying the maturation of learned avoidance

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Microbiome;Nutrition;Pain Research;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Approximately 176 million women worldwide have endometriosis, and current treatments are sub-optimal. This project tests a new idea that whereas some gut bacteria promote endometriosis by inducing inflammation, others protect against endometriosis by fermenting fiber to produce short chain fatty acids. In the long term, this project will lead to the development of diagnostic tools and therapies to treat and prevent recurrences of this painful disease.

PI_NAMEs: KOMMAGANI, RAMAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Abdomen;Acceleration;Acetates;Affect;Age;Age Years;Bacteria;Basic Science;Butyrates;Cell Physiology;Cells;chronic pelvic pain;Consumption;cytokine;Data;Development;Diagnosis;diagnostic development;Diagnostic tests;diagnostic tool;Diet;Dietary Fiber;dietary supplements;Disease;Endometrial;endometriosis;Estrogens;experience;Feces;Fermentation;Fiber;Future;Genetic Transcription;Goals;Greater sac of peritoneum;Growth;Growth Factor;gut bacteria;gut microbiome;gut microbiota;hormone therapy;Human;Immune;Implant;In Vitro;in vivo;Inflammation;Inflammatory;Injections;Interleukin-1 beta;Lesion;Macrophage;Mammals;Mediating;Metabolic;microbiota;Modeling;Mus;National Institute of Child Health and Human Development;Operative Surgical Procedures;Oral;Organ;Pain;Pelvis;Peritoneal;Peritoneal Fluid;Peritoneal Macrophages;prevent;Probiotics;Propionates;Publishing;Recurrence;release factor;Reporting;reproductive;Retrograde Menstruation;Role;side effect;stool sample;Strategic Planning;Surface;Testing;Text;theories;Tissues;tool;treatment strategy;United States;Volatile Fatty Acids;Woman;Work

PROJECT_TITLE: Role of the gut microbiota in endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Well-documented phenomena in Alzheimer’s disease involve cases where some individuals do not manifest Alzheimer’s disease proteins in their brain despite exhibiting known Alzheimer’s disease risk factors (termed resistance), while others with significant Alzheimer disease burden maintain better-than-expected cognitive performance throughout life (termed resilience). The goal of this project is to develop individualized risk profiles to classify and validate resistance and resilience across 13 data harmonized, independent cohorts of approximately 15,000 individuals. Building individualized risk profiles of resistance and resilience to AD will have broad-sweeping implications for identifying those who will truly benefit from therapeutic intervention, improving diagnostic decision making and optimizing AD prevention trials.

PI_NAMEs: BUCKLEY, RACHEL FRANCES (contact);DONOHUE, MICHAEL C;HOHMAN, TIMOTHY J

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;African American;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;Area;behavioral neurology;Biometry;Black race;Blood Vessels;Brain;burden of illness;Calibration;Classification;Clinical;clinical decision-making;clinical practice;clinical trial recruitment;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive change;cognitive neuroscience;cognitive performance;cohort;Data;data harmonization;Decision Making;dementia risk;demographics;Diagnostic;Education;Epidemiology;Ethnic Origin;Ethnic Population;Exhibits;Female;flexibility;Gender;Genetic;Goals;gray matter;human old age (65+);Impaired cognition;improved;Individual;innovation;intersectionality;Knowledge;Life;Longitudinal cohort;Machine Learning;male;Maps;Measures;Medical;men;Modeling;Neurobehavioral Manifestations;neuroimaging;Neuropsychology;Not Hispanic or Latino;older adult;Pathologic;Pathology;Patients;Phenotype;Population;Positioning Attribute;Positron-Emission Tomography;prediction algorithm;predictive modeling;preservation;Prevention trial;profiles in patients;Proteins;Protocols documentation;Publishing;Race;racial diversity;racial population;resilience;Resistance;Resistance profile;response;Risk;Risk Estimate;Risk Factors;Sample Size;screening;sex;Signal Transduction;social culture;Structure;Symptoms;tau Proteins;Theoretical model;theories;Therapeutic Intervention;vascular factor;White Matter Hyperintensity;Woman;β-amyloid burden

PROJECT_TITLE: Building predictive algorithms to identify resilience and resistance to Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-B(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: Project Narrative The microglial receptor TREM2 is a genetic risk factor for Alzheimer’s disease (AD). We will investigate the impact of AD-associated TREM2 gain-of-function mutations on AD pathology using our collection of AD genetic datasets, together with our novel animal models of neuroinflammation and iPSC-derived human microglia-like cells. The proposed study will elucidate novel molecular mechanisms underlying microglial pathology in AD and will facilitate AD therapeutics targeting TREM2.

PI_NAMEs: GRICIUC, ANA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acute-Phase Reaction;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid beta-42;Amyloid beta-Protein;anakinra;Animal Model;Astrocytosis;Attenuated;Binding;Brain;case control;Cell Culture Techniques;Cell Line;Cell surface;Cells;Cognition;cognitive function;Collection;CRISPR/Cas technology;cytokine;Data;Data Set;Disease associated microglia;Drug Compounding;drug development;Family;gain of function;gain of function mutation;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Databases;Genetic Diseases;genetic risk factor;genome sequencing;genome wide association study;glial activation;Goals;Human;IL8 gene;Immune response;improved;induced pluripotent stem cell;insight;Interleukin-1 beta;Interleukin-6;Knock-out;Late Onset Alzheimer Disease;Ligands;Link;Lipopolysaccharides;loss of function;Microglia;Molecular;Mus;Mutation;National Institute of Mental Health;Nerve Degeneration;neuroinflammation;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathology;Phagocytosis;programs;receptor;recruit;Regulation;Reporter;Reporting;response;risk variant;Role;Sampling;Senile Plaques;Signal Pathway;Signal Transduction;System;Testing;Therapeutic;therapeutic target;Tissue-Specific Gene Expression;transcriptome sequencing;TREM2 gene;uptake;Variant;whole genome

PROJECT_TITLE: Role of TREM2 gain-of-function mutations in modulating microglial pathology in Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Chronic Pain;Genetics;Neurosciences;Pain Research;Rehabilitation;Stroke

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: The ability of the brain’s neural circuits to re-organize after amputation, nerve damage or stroke mediates optimal recovery after a traumatic event, but this neural plasticity can also cause problematic phenotypes such as chronic pain, phantom limb pain or hyperalgesia. The mechanisms underlying these adaptations are poorly understood. Basic research findings from this study will elucidate the specific neurons, synapses and receptors in the circuit underlying adaptive or maladaptive plasticity after peripheral nerve transection.

PI_NAMEs: PETRUS, EMILY ROSE (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Affect;American;Amputation;Amputees;Anatomy;Animal Model;Animals;Anxiety;Area;barrel cortex;Basic Science;Behavior;Behavior assessment;Behavioral;Bilateral;Biological Assay;Brain;Brain region;Broca's area;Calibration;cell cortex;Cells;central nervous system injury;Characteristics;Chemosensitization;chronic pain;chronic painful condition;Clinical;Complex Regional Pain Syndromes;Corpus Callosum;Data;Denervation;Electrophysiology (science);Equilibrium;Event;Exhibits;experience;experimental study;Fiber;Foundations;Functional Magnetic Resonance Imaging;Gene Expression;Genetic;Goals;Human;Hyperactivity;Hyperalgesia;imaging study;in vivo;Injections;Injury;Intervention;Knowledge;Label;Language;Left;Life;limb loss;Limb structure;Malignant Neoplasms;Mediating;military service;Modification;nerve damage;nerve injury;nerve transection;neural;neural circuit;Neuronal Plasticity;Neurons;Output;Pain;pain reduction;Patient imaging;Patients;Pattern;Peripheral nerve injury;peripheral nerve transection;Persons;Phantom Limb Pain;Phase;Phenotype;post stroke;postsynaptic;presynaptic;Prosthesis;receptor;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Resolution;Rest;Rodent;Secondary to;Sensory;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;somatosensory;Stroke;Subgroup;Synapses;synaptic function;Synaptic plasticity;System;Therapeutic;Tissues;Training;traumatic event;Vascular Diseases;Vibrissae;Viral;Virus

PROJECT_TITLE: The Mechanisms and Functional Consequences of Interhemispheric Plasticity

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Nutrition;Physical Activity;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Regular exercise provides numerous metabolic and cardiovascular health benefits, however significant inter- individual differences exist in the cardiometabolic responses to regular exercise and there remains a limited understanding of the molecular mechanisms through which exercise confers its salutary effects. The goal of this proposal is to identify new molecular pathways and/or predictors of chronic exercise-induced cardiometabolic changes by integrating genetics, metabolomics and richly-phenotyped cardiometabolic traits from a completed chronic exercise study as well as large population-based cohort studies. In parallel with these aims, this proposal will generate cross-sectional metabolomics and cardiac imaging data in individuals with metabolic syndrome as preliminary data for a future exercise trial.

PI_NAMEs: ROBBINS, JEREMY  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Aerobic Exercise;Affect;African American;Alanine;Alanine-glyoxylate aminotransferase;Aminoisobutyric Acids;Attenuated;Award;bariatric surgery;Biochemical;Biochemical Pathway;Biological;Biological Markers;Blood Pressure;cardiac magnetic resonance imaging;Cardiac Output;Cardiology;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career development;caucasian American;Chronic;Clinical;Clinical Trials;clinically relevant;cohort;Cohort Studies;Data;Data Set;design;Development;Diabetes Mellitus;endurance exercise;Enzymes;Exercise;Exercise Physiology;exercise training;Faculty;Family Study;Fatty acid glycerol esters;Foundations;Future;Genetic;Genetic Determinism;Genome;genome resource;Glycine;Goals;Guidelines;Health;Health Benefit;Heart failure;heart imaging;Heart Rate;high risk;human data;improved;Individual;Individual Differences;insight;insulin sensitivity;Investigation;Israel;Jackson Heart Study;laboratory experience;Left;Lipids;Liver;Measures;Medical center;member;Mendelian randomization;Mentors;Mentorship;Meta-Analysis;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;metabolomics;Methods;Molecular;Molecular Profiling;Myocardial dysfunction;N,N-dimethylarginine;n-pentanoic acid;novel;novel therapeutics;Outcome;Participant;Pathway interactions;Patients;Phenotype;Physiological;Pilot Projects;Plasma;Population;population based;prevent;Prevention;Production;Protocols documentation;Publishing;Research;Resources;response;Science;sedentary;skills;small molecule;Standardization;Stimulus;symposium;Techniques;Training;Training Programs;trait;Translating;Translational Research;Ventricular;VO2max;Work

PROJECT_TITLE: DMGV and the AGXT2 pathway in chronic exercise-induced cardiometabolic adaptations.


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: COLLEGE PARK

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Mortality and Morbidity in biomaterial and medical device-induced foreign body response (FBR) are very high and are directly related to the development of inflammation and fibrosis in affected organs/tissues. The results of this proposal promise to define the role of microRNA-146a in the pathogenesis of FBR, and may lead to novel and effective therapeutics for FBR and other fibrotic disorders.

PI_NAMEs: HE, XIAOMING ;RAHAMAN, SHAIK O (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;Adhesions;Affect;Alginates;Atomic Force Microscopy;Biocompatible Materials;Bone Marrow;Cell fusion;Cell Physiology;Cells;Cessation of life;Chronic;Cicatrix;Collagen;Conditioned Reflex;Cues;Data;Development;Devices;Diabetic mouse;Disease;Encapsulated;Extracellular Matrix;Failure;Family;fibrogenesis;Fibrosis;Foreign Bodies;Foreign-Body Giant Cells;Gene Expression;Generations;Genetic;Goals;Human;Hydrogels;Implant;implantation;improved;in vitro Model;in vivo;Inflammation;Inflammatory;inflammatory marker;insight;intraperitoneal;Ion Channel;islet;Islets of Langerhans;Knock-out;Knockout Mice;Laboratories;Link;loss of function;Macrophage;Macrophage Activation;mechanical signal;mechanical stimulus;mechanotransduction;Mediating;Medical;Medical Device;Microcapsules drug delivery system;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;mouse model;Mus;novel;novel strategies;Organ;Pathogenesis;Pathway interactions;Patients;Performance;Phagocytosis;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;Play;Process;Protein Isoforms;Proteins;receptor;reconstitution;Regulation;Regulator Genes;Reporting;Research;response;Role;Severities;Shapes;subcutaneous;Testing;therapeutic miRNA;therapeutically effective;Tissues;Traction Force Microscopy;transcriptome sequencing;TRPV channel;Untranslated RNA;Vanilloid;Work

PROJECT_TITLE: Investigate the mechanisms underlying microRNA-146a activity in regulation of foreign body response to biomaterials

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The relevance of this work for public health is that the comprehensive determination of how genomic information specifies proper execution of spatial and temporal gene expression programs is essential for understanding how cells divide or respond to their environment, for identifying the regulatory mechanisms that control development, for learning dysregulation in disease, for studying phenotypic variations among human populations, and for determining the clinical significance of genomic variation.

PI_NAMEs: WANG, TING  (contact);YUE, FENG

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Adopted;Adoption;Affect;analysis pipeline;Bioinformatics;Biological Assay;biological research;Biology;Books;Catalogs;Cells;clinically significant;Communication;Communities;Community Outreach;complex data;Computer Analysis;computerized tools;Controlled Vocabulary;Data;Data Analyses;data analysis pipeline;Data Collection;data format;data integration;data mining;data portal;data resource;Data Set;data standards;data visualization;Databases;Development;Disease;distributed data;Documentation;Educational Materials;Educational workshop;Ensure;Environment;epigenome;experience;Feedback;Gene Expression;Genes;Genome;genome browser;genome resource;genomic data;genomic variation;Genomics;Goals;Housing;Human;human pangenome;improved;Laboratories;large datasets;Lead;Learning;Maps;meetings;member;Metadata;metadata standards;Methods;Modeling;Mus;novel;operation;outreach;outreach program;Participant;Pathway Analysis;Periodicals;Phenotype;Population;Process;Production;programs;Progress Reports;Protocols documentation;Provider;Public Health;Quality Control;Reporting;Research;Resources;Series;service organization;Shapes;Specific qualifier value;Speed;Structure;symposium;System;Technology;Testing;tool;Training;Update;user-friendly;Variant;verification and validation;Vision;Visualization;web portal;webinar;Work;working group;Writing

PROJECT_TITLE: WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative: Substance use disorder is a chronic, long-lasting disorder in which patients suffer from high rates of relapse despite successful attempts at abstinence. The goal of this proposal is to delineate the role of circular RNAs in drug-seeking phenotypes to uncover novel mechanisms that can be targeted for treatment of substance use disorder. This proposal will provide critical information on the neurobiological adaptations that the brain undergoes in response to drugs while also exploring the molecular biology of a class of RNA previously unstudied in addiction models.

PI_NAMEs: DAWS, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;Address;Area;Award;Behavior;Behavioral;behavioral phenotyping;Binding;Biogenesis;Brain;Brain region;Cessation of life;Chronic;Chronic Disease;circular RNA;Cognitive;cost;Data Set;Disease;Drug Exposure;drug seeking behavior;Enzymes;Epigenetic Process;Extinction;Gene Expression;genetic manipulation;Genetic Transcription;Goals;Heroin;insight;interdisciplinary approach;Messenger RNA;MicroRNAs;Modeling;Molecular;Molecular Biology;Motivation;Neurobiology;Neurons;novel;Opioid;opioid use disorder;Outcome;Overdose;Patients;Pharmaceutical Preparations;Phenotype;Process;Proteins;Public Health;Rattus;Rehabilitation therapy;Relapse;Reporting;Research;response;Rewards;RNA;RNA Splicing;Role;Self Administration;Signal Pathway;Signal Transduction;Substance abuse problem;Substance Use Disorder;targeted treatment;Translations

PROJECT_TITLE: Circular RNA signaling in opioid seeking phenotypes


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PHR: Project Narrative Our earlier work establishing aberrant regulation of mTORC1 and mTORC2 signaling in NF2 led to clinical trials with mTORC1 inhibitor everolimus for NF2, and dual mTORC1/mTORC2 inhibitor, AZD2014, for NF2- associated and sporadic meningiomas. Our ongoing studies uncover role of growth factors and other receptor tyrosine kinases in NF2-negative tumors, and potential cross talk between mTOR and other signaling pathways. This project will explore these druggable therapeutic targets along with other promising drugs in clinical development using cellular and animal models of NF2-deficient meningioma, which will have a direct impact on developing novel therapeutic strategies and promoting public health.

PI_NAMEs: RAMESH, VIJAYA  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 14q;Acoustic Neuroma;Adult;Alleles;Anaplastic Meningioma;Animal Model;antitumor effect;APLN gene;Arachnoid mater;Back;Benign Meningiomas;Biological;bioluminescence imaging;Cell Line;Cell model;Cells;chromosome 22q loss;Clinical;clinical care;clinical development;Clinical Trials;Collaborations;comparative genomic hybridization;CRISPR/Cas technology;cytotoxic;Dasatinib;Data;Drug Combinations;drug efficacy;Drug Screening;Drug Targeting;effective therapy;Enzymes;Eph Family Receptors;ERBB3 gene;Exhibits;Family;follow-up;FRAP1 gene;Future;Genetic Heterogeneity;Genetic Transcription;genome editing;Genomic Instability;Growth;Growth Factor;heparin-binding EGF-like growth factor;Heregulin;Human;IGF1R gene;Implant;In Vitro;in vivo;in vivo evaluation;in vivo Model;inhibitor;Intracranial Neoplasms;Ligands;Luciferases;Maximum Tolerated Dose;Measures;member;meningioma;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;mTOR Inhibitor;multicatalytic endopeptidase complex;Mus;Mutation;Names;National Center for Advancing Translational Sciences;neoplastic cell;Neuregulins;Neurofibromatosis 2;novel;novel therapeutic intervention;Null Lymphocytes;Ohio;Operative Surgical Procedures;Outcome Study;Pathway interactions;Pediatric Hospitals;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phosphotransferases;pre-clinical;Proliferating;Proteasome Inhibitor;Proto-Oncogene Protein c-kit;Public Health;Publishing;Radiation;Randomized;Receptor Protein-Tyrosine Kinases;Regulation;Research;Resected;response;Role;Screening Result;SDZ RAD;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skull base;small molecule inhibitor;src-Family Kinases;System;Systemic Therapy;targeted treatment;Testing;therapeutic target;transcriptome;transcriptome sequencing;Translating;tumor;tumor growth;tumor heterogeneity;Tumor Suppressor Genes;Ubiquitin;Ubiquitin-Activating Enzymes;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: NF2-Associated Meningiomas: From Omics Discovery to Targeted Therapy

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Understanding the initiation and progression of diabetes is paramount to designing therapies to block or reverse disease. Here, we investigate molecular mechanisms of cellular stress responses in diabetes pathogenesis, and leverage our insights to identify new targets to develop novel therapies for the treatment of the disease. We use sophisticated genetic and pharmacological tools focusing exclusively on human stem cell- derived beta and islet cells to achieve these goals.

PI_NAMEs: HEBROK, MATTHIAS ;PAPA, FEROZ R (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Affect;Alleles;Beta Cell;biological adaptation to stress;Blood Glucose;cell dedifferentiation;Cell Nucleus;Cell Physiology;Cells;Cellular Stress;chemical genetics;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;coping mechanism;Cytoprotection;Cytosol;Data;Defect;Degenerative Disorder;Deterioration;Diabetes Mellitus;diabetes pathogenesis;dimer;Disease;Disease Progression;Endoplasmic Reticulum;endoplasmic reticulum stress;engineered beta cell;exhaustion;Functional disorder;Genetic;Genetic Transcription;Goals;Health;Hormone secretion;Human;human embryonic stem cell;Human Engineering;human stem cell-derived;human stem cells;innovation;insight;Insulin;insulin secretion;Intervention;Islet Cell;kinase inhibitor;loss of function;Maintenance;Marriage;Mitochondria;Modeling;Molecular;novel;novel strategies;novel therapeutics;Organelles;Outcome;Output;Pancreas;Participant;Pathology;Pathway interactions;pharmacologic;Pharmacology;Physiological;Population;preservation;prevent;Prevention;Production;Productivity;progenitor;Protein Biosynthesis;protein folding;Proteins;response;Role;Secretory Cell;sensor;Severity of illness;Signal Pathway;Signal Transduction;small molecule;stem;stem cell population;stem cells;Stress;System;Testing;Therapeutic;Therapeutic Intervention;therapy design;tool;transcription factor;type I and type II diabetes;Variant;Work

PROJECT_TITLE: Modulating intrinsic beta cell stress to block diabetes pathogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE This project aims to explore how neuromodulation plays a critical role in valence assignment in the basolateral amygdala, a site identified as a divergence point in circuits mediating positive and negative valence. It will test the hypotheses that neuromodulation can extend time scales and guide plasticity to the appropriate synapses and downstream circuits during learning.

PI_NAMEs: TYE, KAY MAXINE (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: addiction;Affect;Amygdaloid structure;Animals;antagonist;Anxiety;Architecture;Association Learning;Attenuated;Behavior;Behavioral;Bipolar Disorder;Brain;Cell surface;Cells;Chemosensitization;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cues;Data;differential expression;Discrimination;druggable target;effective therapy;Electrophysiology (science);Fright;Funding;G-Protein-Coupled Receptors;Genes;Geniculate body structure;glutamatergic signaling;Glutamates;Goals;Hippocampus;Impairment;in vivo;knock-down;Learning;Long-Term Potentiation;Maintenance;Medial;Mediating;memory retrieval;Mental Depression;Mental disorders;Modeling;Mus;Negative Valence;nerve supply;neural;neural circuit;Neuromodulator;Neurons;Neuropeptides;neuroregulation;Neurotensin;neurotensin type 1 receptor;Noise;novel;novel strategies;novel therapeutics;optogenetics;Outcome;Output;parallel processing;Pathologic;pharmacologic;Play;Positioning Attribute;Positive Valence;postsynaptic;Prevalence;Property;Punishment;receptor;Research;response;Rewards;Role;Schizophrenia;self-directed learning;side effect;Signal Transduction;Site;Source;Stimulus;Surface;Synapses;System;Testing;Textbooks;Thalamic structure;therapeutic development;Time;transcriptome;transmission process;Ventral Nuclear Group;Vision;Work;Writing

PROJECT_TITLE: Solving the Valence Assignment Problem

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance to public health We are developing a set of technologies to enable real-time intraoperative microscopy of the final resection margins of low-grade glioma (LGG) patients who have been administered with 5-ALA prior to surgery (FDA approved in 2017). These quantitative and sensitive imaging techniques have the potential to improve the extent of resection for LGG patients, and therefore to improve patient outcomes such as overall survival and progression-free survival (time to recurrence).

PI_NAMEs: LIU, JONATHAN T.C. (contact);SANAI, NADER

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Adult;Aminolevulinic Acid;Area;automated algorithm;Biological;Biophotonics;brain tissue;Child;Clinical;Clinical Research;clinically relevant;Collection;Computer software;Confocal Microscopy;Data;design;Devices;Diffuse;Engineering;Excision;FDA approved;Fluorescence;fluorescence-guided surgery;Future;Glioma;high resolution imaging;Histology;Image;Image Analysis;image guided;image processing;Image-Guided Surgery;imaging modality;Imaging Techniques;Imaging technology;Immunohistochemistry;improved;in vivo;indexing;industry partner;innovation;instrumentation;lens;Location;Machine Learning;Magnetic Resonance Imaging;Mechanics;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Molecular;Nature;neoplastic cell;Neurologic;Neuronavigation;neurosurgery;Operative Surgical Procedures;Optics;Outcome;overexpression;Pathologist;Patient-Focused Outcomes;Patients;Pattern;Performance;Postoperative Period;Procedures;Progression-Free Survivals;Proliferating;prototype;Public Health;Quality of life;radiological imaging;Randomized;Recurrence;Recurrent disease;Reporting;Residual state;Resolution;Sampling;Sampling Biases;Specimen;Speed;Sterility;Surgeon;Surgical margins;survival outcome;Techniques;Technology;Time;Tissues;training data;tumor;Tumor Burden;Validation;Visualization

PROJECT_TITLE: In vivo dual-axis confocal microscopy of 5-ALA-induced PpIX to guide low-grade glioma resections


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Despite racial/ethnic disparities in outcomes for younger adults with traumatic brain injury (TBI), there are no U.S. standards for TBI transitional care for patients discharged home from acute hospital care. To enhance the standard of care, we will examine the efficacy of our existing intervention named BETTER (Brain Injury, Education, Training, and Therapy to Enhance Recovery), a culturally-tailored, patient- and family-centered TBI transitional care intervention, compared to usual care, among younger adults with TBI and families. The knowledge generated will drive improvements in health equity for younger adults with TBI of various races/ethnicities and families, resulting in improved health of the public.

PI_NAMEs: OYESANYA, TOLU O. (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Activities of Daily Living;Acute;Address;Affect;Age;Area;arm;Behavior Therapy;Behavioral;bilingualism;Black race;Brain Injuries;budget impact;care coordination;care costs;caregiver strain;Caring;Clinical;clinical encounter;clinical practice;Clinical Skills;Cognitive;Communities;Complex;Coping Skills;cost;Cost Analysis;culturally appropriate intervention;Dependence;design;Education;Effectiveness;efficacy evaluation;Emotional;Enrollment;Ensure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Event;evidence base;Face;Family;family management;Future;Goals;Health;health care service;health equity;Health Services Accessibility;Health system;Healthcare;Home;hospital care;hospital readmission;hospitalization rates;Hour;Impairment;improved;Incidence;Individual;Inequity;Insurance;Intervention;Interview;Knowledge;Language;Latino;Linguistics;Location;Manuals;minority communities;multi-site trial;Myocardial Infarction;Names;Outcome;Participant;Patient Care;Patient Discharge;Patient Transfer;Patient-Focused Outcomes;Patients;Persons;Pilot Projects;preference;primary outcome;Process;Protocols documentation;Provider;Public Health;Quality of life;Race;racial disparity;racial minority;racial population;Randomized;Randomized, Controlled Trials;Recovery;recruit;Reduce health disparities;Research;Research Methodology;Research Personnel;Resources;secondary outcome;Self Management;Services;sex;SF-36;Site;Spanish;Spanish/English;standard of care;Stroke;Structure;Symptoms;TBI Patients;theories;Time;Training;Training and Education;Transitional Care Planning;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment as usual;United States National Institutes of Health;young adult

PROJECT_TITLE: A Randomized Controlled Trial of BETTER, A Transitional Care Intervention, for Diverse Patients with Traumatic Brain Injury and Their Families

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Many preclinical and some clinical studies suggest that the irradiation at ultra-high dose rates, namely FLASH-RT, can substantially reduce normal-tissue toxicities while maintaining tumor response, compared with the irradiation at conventional dose rates. However, the effectiveness of FLASH-RT for general cancer patients is to be further validated through clinical trials, for which this project will develop first-of-its-kind simultaneous dose and dose rate optimization (SDDRO) methods with FLASH optimization capability that is currently unavailable and urgently needed for clinical FLASH-RT. The availability of FLASH-RT treatment planning system with SDDRO will facilitate animal studies and clinical trials on FLASH-RT, which will potentially become a new paradigm for cancer radiotherapy in general.

PI_NAMEs: GAO, HAO  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Animals;Award;Biology;cancer cell;Cancer Patient;cancer radiation therapy;Characteristics;Clinical;Clinical Research;clinical translation;Clinical Trials;conventional dosing;Dose;Dose Rate;dosimetry;Effectiveness;Future;high risk;improved;industry partner;innovation;Intensity modulated proton therapy;irradiation;Joints;Location;Lung;lung volume;Methods;Modality;Modeling;Nature;Normal tissue morphology;novel;Outcome;Paper;Patients;Physics;Positioning Attribute;pre-clinical;predictive modeling;preservation;prospective;proton beam;Protons;Quality of life;Radiation;Radiation Dose Unit;radiation risk;Radiation therapy;Radiobiology;response;Structure;System;Technology;Testing;Therapy Clinical Trials;Time;Toxic effect;Translations;transmission process;treatment planning;treatment site;tumor;Uncertainty;Validation;verification and validation;Work

PROJECT_TITLE: Simultaneous dose and dose rate optimization for clinical FLASH proton radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Lung;Patient Safety;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Oxygen is a lifesaving therapy but needs to be balanced since both high and low extremes are harmful. This proposal describes an innovative approach to maintain targeted oxygenation preventing both extremes. The proposal also looks at identifying biomarkers of oxygen toxicity, which can help health care workers prevent oxygen induced toxicity and result in shorter time on mechanical ventilation, less organ failure and better life quality after illness.

PI_NAMEs: PANNU, SONAL R. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Active Learning;Acute Lung Injury;Adverse effects;Advisory Committees;Affect;Algorithms;Automobile Driving;Bioinformatics;Biological Markers;biomarker identification;Bronchoalveolar Lavage Fluid;cardiovascular collapse;career;career development;cell injury;Clinical;Clinical Research;Clinical Trials Design;Cluster randomized trial;Cognitive;cognitive function;Coupled;Critical Care;Critical Illness;Data;design;Development;Doctor of Medicine;efficacy evaluation;Electronic Health Record;Electronics;Enrollment;Ensure;Environment;Event;Exclusion;Exposure to;follow-up;Funding;Future;Goals;Guidelines;Health Personnel;Hour;Hyperoxia;hyperoxia induced lung injury;Hypoxemia;Hypoxemic Respiratory Failure;Hypoxia;improved;improved outcome;Injury;innovation;Interdisciplinary Study;interest;Intervention;Knowledge;Laboratory Technicians;Length of Stay;Life;Lipid Peroxidation;lipidomics;Lipids;Lung;lung failure;lung injury;Mass Spectrum Analysis;Measures;Mechanical ventilation;Mediating;Medicine;Mentors;Metabolic acidosis;mortality;Multi-Institutional Clinical Trial;novel;Ohio;Omega-3 Fatty Acids;Organ failure;Outcome;Oxidative Stress Induction;oxidized lipid;Oxygen;Oxygen Therapy Care;oxygen toxicity;patient population;Patient-Focused Outcomes;Patients;Peripheral;peroxidation;Persons;Physicians;Physiological;Pilot Projects;Population;Pragmatic clinical trial;prevent;Prevention;primary outcome;Protocols documentation;Quality of life;Questionnaires;Randomized;Recording of previous events;Research;Research Personnel;Resources;Respiratory Failure;Rice;Safety;Scientist;secondary outcome;skills;Sleep;Sonal;statistics;supplemental oxygen;Supplementation;Survivors;Telephone;Therapeutic;Time;tissue oxygenation;Tissue Preservation;Tissues;Titrations;tool;Toxic effect;Training;translational approach;Translational Research;translational scientist;treatment as usual;Universities;Unsaturated Fatty Acids;Variant;Ventilator

PROJECT_TITLE: Leveraging Automated Optimization of Inspired Oxygen and Oxidized Biomarker Lipidomics for Targeted Oxygenation during Mechanical Ventilation: a Pragmatic Clinical Trial

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ORG_DEPT: NEUROLOGY

PHR: Overall: Project Narrative The Adult Children Study has created a cohort of middle age and older individuals, with and without a parental history of Alzheimer disease (AD), who longitudinally undergo a comprehensive battery of biological, clinical, and cognitive tests to identify the earliest brain changes of AD prior to any clinical symptoms. Our hypothesis is that the compromise of neuronal function by these brain changes predicts the transition from preclinical AD to symptomatic AD. This renewal will focus on the factors that accelerate or prevent development of symptomatic disease.

PI_NAMEs: MORRIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Adult Children;adverse childhood events;Affect;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Apolipoprotein E;Astrocytosis;bacterial community;Biological Markers;Biological Testing;Biometry;Blood;Blood Pressure;Body mass index;Brain;Brain-Derived Neurotrophic Factor;cardiovascular risk factor;Cerebrospinal Fluid;Cerebrovascular Disorders;Cerebrum;Clinical;Cognitive;cognitive performance;cognitive testing;cohort;Cohort Studies;Data;data management;Development;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;DNA;Enteral;Feces;Framingham Heart Study;Functional disorder;Funding;Genetic Risk;Genotype;Gliosis;Glycosylated hemoglobin A;gut inflammation;gut microbiome;Head;Hydrocortisone;Image;Impaired cognition;Individual;Inflammation;Inflammatory;inflammatory marker;Intestinal permeability;Intestines;life span;Liquid substance;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mediating;Metagenomics;metatranscriptomics;middle age;mild cognitive impairment;Moderate Exercise;molecular marker;neighborhood disadvantage;Nerve Degeneration;neural;Neuronal Injury;Neurons;novel;offspring;Older Population;Parents;Participant;Patient Self-Report;Pattern;perceived stress;Physical activity;Plasma;polygenic risk score;Positioning Attribute;Positron-Emission Tomography;pre-clinical;predictive marker;prevent;Race;radioligand;Recording of previous events;Risk;Risk Factors;risk prediction;RNA;social health determinants;stool sample;Stress;Structure;Sum;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Time;Tracer;White Matter Hyperintensity

PROJECT_TITLE: Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Adult Children;Advisory Committees;Age;Alzheimer's Disease;Alzheimer’s disease biomarker;Biological Markers;Biometry;Clinical;Cognitive;cohort;data harmonization;data integration;data management;Databases;Disease Progression;Effectiveness;Enrollment;Ensure;Enteral;Evolution;Functional disorder;Funding;Gifts;Goals;gut microbiome;Head;healthy aging;Image;imaging biomarker;Impairment;Inflammation;Informatics;interest;International;Leadership;Liquid substance;Mediator;Monitor;National Institute on Aging;Normalcy;Onset of illness;parent grant;Pathogenesis;Periodicals;Physical activity;Pilot Projects;Plasma;pre-clinical;preclinical study;predictive marker;Predictive Value;Program Research Project Grants;programs;Race;Research;Resources;risk prediction;Senile dementia;social health determinants;Structure;tau Proteins;Universities;volunteer;Washington

PROJECT_TITLE: Administration Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Copper is an essential trace nutrient important for fundamental processes including respiration, removal of toxic oxygen radicals, cell signaling, and tissue development. Copper is also toxic, and impaired import and distribution is associated with a number of human diseases including Menkes disease, a fatal genetic Cu deficiency that is characterized by severe postnatal developmental defects. These studies focus on gaining a deeper knowledge of how cells balance copper levels during dynamic states like tissue development by focusing on how the copper is prioritized to control the signaling pathways that promote or inhibit development and how expression of genes regulating Cu import and distribution are regulated.

PI_NAMEs: VEST, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: ATP phosphohydrolase;Cell Differentiation process;Cells;cofactor;Copper;Data;Defect;Deficiency Diseases;Development;developmental disease;differentiation in vitro;Disease;Equilibrium;Excision;Gene Expression;Genetic;Golgi Apparatus;Growth Factor;Homeostasis;human disease;Impairment;in vivo;Iron;Knowledge;Menkes Kinky Hair Syndrome;Metabolic Pathway;Muscle Fibers;Muscle hypotonia;Mutation;Nerve Degeneration;Neurons;Normal tissue morphology;Oxidative Phosphorylation;Post-Transcriptional Regulation;postnatal;posttranscriptional;prevent;Process;programs;Reactive Oxygen Species;Regulation;Regulatory Pathway;Research;Respiration;RNA;Role;Series;Signal Pathway;Signal Transduction;skeletal muscle differentiation;therapy development;Tissue Differentiation;Tissues;Trace Elements Nutrition;Work

PROJECT_TITLE: Function and regulation of copper in mammalian tissue differentiation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

PROJECT_TERMS: actigraphy;Administrative Supplement;Adult Children;African American;Age;Age Years;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Apolipoprotein E;Area;Biological;Biological Markers;Biostatistics Core;Blood;Body mass index;Cerebrospinal Fluid;Clinical;Clinical assessments;Cognitive;cognitive testing;cohort;Cohort Studies;Collection;cost;Data;data management;Dementia;Diastolic blood pressure;Disease Progression;DNA;Eligibility Determination;Enrollment;Enteral;Exercise;Exercise Test;Fasting;Functional disorder;Generations;Genetic;Genotype;Glycosylated hemoglobin A;Goals;gut microbiome;Height;human old age (65+);Hydrocortisone;Image;imaging study;Individual;instrument;International;Learning;Life Cycle Stages;Liquid substance;Longitudinal Studies;Measures;metropolitan;mild cognitive impairment;Mission;Monitor;Neurologic Examination;operation;Parents;Participant;participant enrollment;patient engagement;Physical activity;Plasma;polygenic risk score;Population;pre-clinical;predictive marker;Procedures;Program Research Project Grants;Protocols documentation;Psychometrics;Questionnaires;Recording of previous events;recruit;repository;Research;risk prediction;RNA;Sampling;Schedule;Serology;Shapes;social health determinants;stool sample;tau Proteins;virtual;Weight

PROJECT_TITLE: Clinical Core


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE We propose to characterize the intrinsic antiviral response as it relates to a novel Drosha-containing high molecular weight structure we have termed the ADAR-RISC Complex (ARC). This work will enhance our understanding of virus and host interactions and could significantly advance future therapeutics.

PI_NAMEs: TENOEVER, BENJAMIN R. (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: ADAR1;antagonist;Anti-viral Response;Arthropods;Biochemical;Biochemistry;Biogenesis;Biological;Biological Assay;Biology;C-terminal;Caveolae;caveolin 1;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;CRISPR screen;Cytoplasm;Deamination;Detection;Escape Mutant;Eukaryotic Cell;Event;Excision;experimental study;Family;Fluorescence;Future;Generations;homologous recombination;Immunoprecipitation;Infection;Integration Host Factors;Interferon Type I;Interferons;invention;Invertebrates;Life;Mammals;Mediating;Mediator;member;MicroRNAs;Molecular;Molecular Biology;Molecular Weight;novel;nuclease;pathogen;Pathway interactions;Phosphotransferases;Physiological;Plants;Play;Positioning Attribute;Process;Prokaryotic Cells;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;Recombinants;response;Ribonuclease III;RNA;RNA Editing;RNA Interference;RNA metabolism;RNA Viruses;RNA-Induced Silencing Complex;Role;Sendai virus;Signal Transduction;Site;Small RNA;Specificity;Structure;System;Terminator Codon;Testing;Therapeutic;Transcript;Translations;Trees;Variant;Vertebrates;Viral;Viral Proteins;viral RNA;Virus;Virus Diseases;whole genome;Work

PROJECT_TITLE: Defining the Biology of the ADAR1-RISC Complex

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SCHINDLER, SUZANNE ELIZABETH (contact)

PROJECT_TERMS: Acceleration;Adoption;Adult;Adult Children;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;assay development;biobank;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Biostatistics Core;candidate marker;cardiovascular risk factor;Cerebrospinal Fluid;Clinical;clinical practice;clinical predictors;Clinical Trials Design;Cognitive;cognitive function;cohort;Collaborations;Collection;Communities;Consensus;Data;data management;data sharing;Database Management Systems;Dementia;diagnostic criteria;Diffusion Magnetic Resonance Imaging;Disease;disease diagnosis;Electronics;end stage disease;Equipment and supply inventories;Etiology;Evaluation;experimental study;Fasting;follow-up;Fostering;Funding;Future;global health;Goals;Grant;gut microbiome;Healthcare Systems;Image;Impaired cognition;Impairment;Individual;Industrialization;Inflammation;Infrastructure;International;Investigation;Laboratories;life span;Liquid substance;Measurement;Measures;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuroinflammation;Nomenclature;Normalcy;novel marker;Participant;Pathology;Patient Care;Performance;Physical activity;Plasma;Positron-Emission Tomography;pre-clinical;preclinical study;preservation;Prevention trial;Procedures;Prognosis;prognostic;Protocols documentation;Qualifying;Quality Control;Reproducibility;Research;Research Personnel;sample collection;Sampling;software systems;specific biomarkers;Standardization;Target Populations;tau Proteins;Tauopathies;therapeutic evaluation;Treatment Efficacy;Universities;Validation;Washington

PROJECT_TITLE: Fluid Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: XIONG, CHENGJIE  (contact)

PROJECT_TERMS: Address;Adult Children;Alzheimer’s disease biomarker;Biometry;Biostatistics Core;Collaborations;Consult;Data;Data Analyses;data management;Data Reporting;Data Set;data sharing;Databases;design;Disease Marker;Ensure;Freezing;Growth;Informatics;Lead;longitudinal analysis;Methodology;Mission;novel;Participant;Pattern;Preparation;Program Research Project Grants;programs;Publications;Qualifying;Quality Control;Reproducibility;Research;Research Personnel;Research Support;Resources;Role;Schedule;Statistical Data Interpretation;Statistical Methods;Techniques;Work

PROJECT_TITLE: Data Management and Biostatistics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: abeta deposition;Address;Adult Children;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Amyloidosis;beta amyloid pathology;Blood;Blood Pressure;Blood Vessels;Body mass index;Brain;Brain Mapping;cardiovascular health;Cerebrospinal Fluid;Cerebrovascular Disorders;cerebrovascular lesion;Cerebrum;Clinical;Cognitive;cognitive performance;Data;Dementia;Deposition;Development;Diet;Diffusion Magnetic Resonance Imaging;Evaluation;Exercise;Functional Magnetic Resonance Imaging;Genetic;Glycosylated hemoglobin A;Goals;Grant;gut microbiome;Hemorrhage;Image;imaging biomarker;imaging modality;Imaging Techniques;Impaired cognition;Impairment;Individual;Infarction;Inflammation;Lead;life span;Life Style;Link;Magnetic Resonance Imaging;Maps;Measures;medial temporal lobe;molecular marker;Nerve Degeneration;nerve injury;neural;neuroinflammation;neuropathology;Normalcy;older adult;Participant;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Physical activity;Physiology;Pittsburgh Compound-B;Positron-Emission Tomography;pre-clinical;Program Research Project Grants;Race;radioligand;Rest;Risk;serial imaging;sex;social health determinants;social influence;Staging;Symptoms;tau aggregation;tau Proteins;Tauopathies;Testing;Thick;uptake;white matter;White Matter Disease;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Tau Burden and Spatial Spread in Preclinical Alzheimer Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE We will use a population-based approach to conduct whole exome sequencing and targeted gene panel sequencing of single and pooled circulating tumor cells (CTCs), in order to identify CTC mutations/genes that are predictive of treatment response and prognosis in patients with metastatic castration-resistant prostate cancer (mCRPC). As, to our best knowledge, the first population study of single-CTC next-generation sequencing study in mCRPC, the findings of our study will significantly improve the potential of CTCs in the clinical management of mCRPC, by precisely tailoring treatment to the genomic make-up of individual CTCs from individual patients.

PI_NAMEs: KELLY, WILLIAM K.;LU-YAO, GRACE ;YANG, HUSHAN  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Aftercare;androgen independent prostate cancer;biomarker identification;Biopsy;Blood;bone;Cancer Center;Cancer Patient;Cancer Prognosis;Cells;Censuses;Characteristics;Clinical;clinical application;Clinical Management;clinical practice;cohort;Collecting Cell;Data;Data Analyses;Detection;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;drug development;Drug resistance;effective therapy;Exhibits;exome sequencing;follow-up;gene panel;Genes;genetic signature;genomic profiles;genomic profiling;Genomics;Germ Lines;Guidelines;Heterogeneity;Heterozygote;high risk;imaging detection;Immune;improved;Individual;individual patient;individualized medicine;liquid biopsy;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Prostate Cancer;Monitor;Mutation;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;next generation sequencing;novel;patient prognosis;Patients;personalized strategies;population based;Population Study;precision medicine;Prediction of Response to Therapy;Primary Neoplasm;Prognosis;prognostic;Prognostic Factor;Progression-Free Survivals;Prostate Cancer therapy;real time monitoring;Reporting;Research Design;response;Science;single cell sequencing;Survival Rate;Testing;Therapeutic;therapy resistant;Time;Tissue Sample;Tissues;treatment planning;treatment response;tumor;tumor heterogeneity;Tumor Tissue;Universities;Validation;Washington;whole genome

PROJECT_TITLE: Genomic profiling of single circulating tumor cells in the precision medicine of metastatic prostate cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of this study is to conduct a Hybrid Type 1 effectiveness-implementation study to evaluate eHealth delivery alternatives for pre-disclosure education and return of actionable genetic research results from a large institutional biobank of healthy participants. We expect this study to provide critical and comprehensive data to inform evidence-based practice guidelines for return of actionable genetic research results to participants.

PI_NAMEs: BRADBURY, ANGELA R. (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Address;Affective;American Society of Clinical Oncology;Award;Behavior;behavioral outcome;biobank;chatbot;Clinical Research;Cognitive;cohort;Communication;Consensus;Consent;Consolidated Framework for Implementation Research;cost;Data;design;Disadvantaged;Disclosure;DNA Library;Education;Educational Intervention;Effectiveness;effectiveness/implementation study;eHealth;Environment;evidence based guidelines;Family Cancer History;Frequencies;Future;future implementation;Genes;Genetic;Genetic Counseling;genetic counselor;Genetic Research;genetic testing;genetic variant;Goals;Guidelines;Health;Hybrids;implementation barriers;Institution;Intervention;intervention delivery;Investigation;Knowledge;Life Style;Methods;Modeling;next generation sequencing;Notification;Outcome;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Penetrance;preference;Privatization;process evaluation;programs;Prospective, cohort study;psychological distress;psychosocial;Randomized;Recommendation;Research;Risk;Self Direction;sociodemographic factors;sociodemographics;Telephone;Test Result;Testing;treatment arm;treatment as usual;uptake;variant of unknown significance

PROJECT_TITLE: RESPECT3: A Randomized type 1 hybrid Effectiveness-implementation Study of returning actionable genetic PanEl researCh resulTs


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Physical Activity;Precision Medicine;Prevention;Social Determinants of Health

PROJECT_TERMS: Adult Children;Affect;African American population;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloidosis;Astrocytosis;beta diversity;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biology;candidate marker;cardiovascular risk factor;Cellularity;cerebral amyloidosis;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cessation of life;Clinical;Cognitive;cohort;Complex;Data;Demographic Factors;Development;Diffusion Magnetic Resonance Imaging;Discrimination;Disease Progression;Disparity;Environmental Risk Factor;Functional disorder;Future;Gliosis;Goals;gut bacteria;gut microbiome;Image;Impaired cognition;improved;Individual;Inflammation;insight;Intestinal permeability;Life Experience;Liquid substance;Measures;Mediating;neighborhood disadvantage;Neuronal Injury;Normalcy;novel;Pathologic;Pathology;Physical activity;Plasma;Play;Population;Positron-Emission Tomography;pre-clinical;predictive marker;Prevalence;Process;Protein Isoforms;Proteomics;racial determinant;rate of change;risk prediction;Role;Sampling;social factors;social health determinants;Social support;Stress;Symptoms;Synapses;tau Proteins;tau-1;Tauopathies;VSNL1 gene;Water

PROJECT_TITLE: Plasma and CSF Biomarkers that Predict Risk for Symptomatic Alzheimer Disease


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences;Nutrition

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: A conserved feature of aging from flies to humans is loss of circadian regulation, or disruption of 24-hour oscillations in behavior and biological function; unfortunately, there are currently few therapeutic interventions that enhance circadian regulation in the elderly. One potential therapeutic intervention is time-restricted feeding, or TRF; this proposal tests the hypothesis that TRF promotes diverse anti-aging health benefits by enhancing tissue-specific circadian clocks and the expression of circadian- regulated genes in different tissues. Here we propose to use the powerful genetic methods in Drosophila to investigate the role of central and peripheral clocks in different TRF-induced health benefits.

PI_NAMEs: SHIRASU-HIZA, MICHELE M (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;Affect;age effect;age related;Aging;aging biomarker;aging brain;aging related;aging related disease;Alzheimer's Disease;Animals;anti aging;Automobile Driving;Autophagocytosis;Behavior;Biological Models;Biological Process;blood glucose regulation;Brain;Candidate Disease Gene;circadian;Circadian gene expression;circadian pacemaker;circadian regulation;Circadian Rhythms;Communication;Complex;Cues;Data;Defect;Diabetes Mellitus;Diet;dietary;Drosophila genus;Eating;Elderly;experimental study;extend lifespan;Fasting;Feedback;feeding;fly;Food;food restriction;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Models;Genetic Transcription;Health;Health Benefit;healthspan;Hour;Human;Hypertension;Immune system;Immunity;improved;Infection;inhibitor;insight;interest;Intestines;Life;life span;lipid metabolism;Lipids;Longevity Pathway;Mammals;Mediating;Metabolic Pathway;Metabolism;Methods;Molecular;Molecular Chaperones;Motor Activity;Mus;Muscle;Nature;Neurons;Obesity;obesity prevention;Oxidative Stress;Pathologic;Pathology;Peripheral;Persons;Phenotype;physical process;Physiological;Physiology;prevent;Process;Proliferating;protein aggregation;Psyche structure;Regimen;Research;Risk Factors;Role;Sleep;stem cells;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Time-restricted feeding;Tissue-Specific Gene Expression;Tissues;tool;transcriptome sequencing

PROJECT_TITLE: Circadian-Regulated Aging Physiologies

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Antimicrobial blue light at 405 nm wavelength has attracted increasing attention because of its intrinsic bactericidal activity against a wide range of pathogenic bacteria. However, Staphylococcus aureus, a serious threat to human health flagged by the U.S. CDC, has been found to be much more tolerant of antimicrobial blue light at 405 nm due to its high antioxidant capability. A recent study discovered that the antioxidant capability of S. aureus can be mitigated using 460-nm wavelength irradiation. As such, this application aims to investigate the utility of an innovative dual-wavelength irradiation strategy, by using the combination of 460 nm and 405 nm wavelength irradiation, for improved killing of S. aureus. If this strategy can be demonstrated to be both effective and safe, it would potentially be a further advancement in the treatment of localized S. aureus infections.

PI_NAMEs: DAI, TIANHONG  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Acinetobacter baumannii;Affect;alternative treatment;Animals;anti-microbial tolerance;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Antioxidants;Attention;Bacteria;bactericide;Biological;bioluminescence imaging;Carotenoids;Cells;Clinic;Clinical;Community-Acquired Infections;Cutaneous;cytotoxic;cytotoxicity;Development;DNA Damage;Effectiveness;effectiveness evaluation;efficacy evaluation;Elderly;Endothelial Cells;Epithelial Cells;Exhibits;Exposure to;Fibroblasts;Foundations;Genetic Engineering;genotoxicity;Health;Hospitalization;Human;Immune;improved;In Vitro;Incidence;Individual;Infection;Inflammatory Response;innovation;Interruption;interstitial;irradiation;keratinocyte;lens;Light;methicillin resistant Staphylococcus aureus;Microbial Biofilms;mortality;Mus;Myoblasts;Needles;Neisseria gonorrhoeae;Nonpharmacologic Therapy;novel;Optics;Oxidative Stress;pathogen;pathogenic bacteria;Penetration;Phagocytes;Photobleaching;Photosensitizing Agents;Pigments;preclinical study;Predisposition;Prevalence;Production;Prophylactic treatment;Protocols documentation;Pseudomonas aeruginosa;Reactive Oxygen Species;real time monitoring;Regimen;Reporting;Resistance development;Resistance profile;resistant strain;Safety;safety study;Site;Staphylococcus aureus;Staphylococcus aureus infection;staphyloxanthin;Testing;Tetracyclines;Therapeutic;Time;Tissues;Toxic effect;Translating;Treatment Cost;Treatment Protocols;Virulent;wound healing

PROJECT_TITLE: Dual-Wavelength Blue Light Irradiation for Improved Treatment of Staphylococcus aureus Infections


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ANCES, BEAU M (contact)

PROJECT_TERMS: Address;Adult;Adult Children;alpha 1-Antitrypsin;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Antibodies;bacterial community;Bacteroidetes;Biological Markers;biomarker identification;Biomass;Blood;Categories;Cells;Cerebrospinal Fluid;Clinical;Cognitive;Cohort Studies;Complex;cost effective;Cross-Sectional Studies;Data;Detection;Disease;Disease Marker;Disease Progression;dysbiosis;early detection biomarkers;Early identification;Endocrine;Endotoxins;Enteral;Environment;Exhibits;Feces;Firmicutes;Foundations;Functional disorder;Gastroenterology;Gastrointestinal tract structure;Gene Expression Profile;Genes;Genetic Transcription;gut dysbiosis;gut inflammation;gut microbiome;gut-brain axis;Health;Home;Human;Immune;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Interleukin-6;Intestinal permeability;Intestines;Kinetics;Knowledge;Leukocyte L1 Antigen Complex;Link;lipopolysaccharide-binding protein;Lipopolysaccharides;longitudinal analysis;Measures;Mediating;Metabolism;metagenomic sequencing;metatranscriptomics;microbial;microbial community;Microbiology;microbiome composition;microbiome research;Modality;multidisciplinary;Nerve Degeneration;Nervous System Physiology;neural;neuroimaging;neuroimaging marker;Neurology;Onset of illness;Organ;Participant;Pathogenesis;Pathway interactions;patient engagement;Permeability;Persons;Physical activity;Plasma;Positron-Emission Tomography;pre-clinical;Reproducibility;Research;Research Personnel;Role;Serum Markers;stool sample;systemic inflammatory response;tau Proteins;tau-1;Taxonomy;Testing;Thinness;Time;uptake;Work

PROJECT_TITLE: Alzheimer Disease Progression, Host Gut Microbiome, and Enteric Dysfunction


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Approximately one-fifth of the world's couples encounter fertility problems, half of them being attributed to the male part. The main cause of this problem is attributed to an insufficient knowledge in sperm physiology at the molecular level. This project will use a cross-disciplinary approach to dissect the regulation of soluble adenylate cyclase in mammalian sperm with the goal of understanding unsolved physiological questions related to the acquisition of sperm fertilizing competence.

PI_NAMEs: KRAPF, DIEGO  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: 3-Dimensional;Adenylate Cyclase;Albumins;Bicarbonates;Binding;Biochemical;Biology;Calcium;Calcium Channel;CatSper;Cell Physiology;Cells;cellular imaging;Competence;Complex;Contraceptive Agents;Couples;Cre-LoxP;Cyclic AMP;Data;Development;Diagnosis;Electrophysiology (science);Emotional;Enzymes;Evolution;experimental study;Exposure to;extracellular;female reproductive tract;Fertility;Fertilization;Flow Cytometry;Functional disorder;Generations;Germ Cells;Goals;GTP-Binding Proteins;Health;Heart;Image;imaging modality;Imaging technology;In Vitro;Infertility;insight;Ion Channel;Ion Transport;Kinetics;Knockout Mice;Knowledge;Maintenance;male;Male Infertility;Measures;Mediating;member;men;Molecular;novel;Outcome;patch clamp;Pathway interactions;pharmacologic;Physiological;Physiology;Process;Production;Protamines;Proteins;Recombinants;Regulation;Regulatory Element;Reporting;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Sperm Capacitation;sperm cell;sperm function;Sperm Head;Sperm Maturation;Sterols;superresolution imaging;superresolution microscopy;synergism;Testing;Time;tool;Transgenic Mice;Transgenic Organisms;Up-Regulation;Wild Type Mouse;Woman;Work;zygote

PROJECT_TITLE: Regulation of Soluble Adenylate Cyclase During Mammalian Sperm Capacitation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: MAYWOOD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Lay Abstract The number of African Americans, Hispanic Americans, American Indians, and Pacific Islanders who are neuroscientists is much lower than would be expected based on their representation in the U.S. population. We will establish a national Mentoring Institute for Neuroscience Diversity Scholars (MINDS) program that will promote the advancement of these underrepresented minorities who are junior faculty members in neuroscience. The program will involve a series of workshops and mentoring over several years with instruction and mentoring in neuroscience research, professional development, and ethics provided by a large number of nationally recognized faculty members. !

PI_NAMEs: TORRES, GONZALO E. (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Academia;Address;Advanced Development;African American;African American population;American Indians;Applications Grants;Area;Award;career;career development;career networking;college;Communication;Data;demographics;design;Development;Development Plans;Disabled Persons;Discipline;Disparity;early-career faculty;Education;Educational process of instructing;Educational workshop;Elements;Ethics;Evaluation;experience;Exposure to;Faculty;Funding;Goals;Grant;Hispanic;Hispanic Americans;implicit bias;Individual;Individualized education program;Institution;Instruction;Interview;Journals;Letters;Manuscripts;Measures;meetings;member;Mentors;Modeling;Monitor;Native Americans;Nature;Neurosciences;Neurosciences Research;Oral;Pacific Islander;Participant;Pathway interactions;patient engagement;peer coaching;Population;Positioning Attribute;Postdoctoral Fellow;Process;Program Development;programs;Publications;Publishing;Recommendation;recruit;Research;Research Project Grants;responsible research conduct;Scholars Program;Self Assessment;senior faculty;Series;skills;success;symposium;Testing;Training;Training Programs;Underrepresented Minority;Underserved Population;United States;Universities;Visit;Work;Writing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

PI_NAMEs: HEAD, DENISE  (contact)

PROJECT_TERMS: actigraphy;Acute;Address;Adult Children;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid deposition;Animals;Biological Markers;Blood;Blood Vessels;cardiorespiratory fitness;cardiovascular disorder risk;cerebrovascular health;Clinical;Cognitive;Data;Development;Disease Progression;Effectiveness;Episodic memory;Etiology;evidence base;Exercise;Framingham Heart Study;Goals;gut microbiome;Health;Heterogeneity;Hippocampus;Human;improved;Individual Differences;Inflammation;insight;interest;Intervention;Knowledge;Life Style;Liquid substance;Literature;longitudinal course;Longitudinal, observational study;Magnetic Resonance Imaging;Maintenance;Measures;medial temporal lobe;Memory;middle age;Modeling;Moderate Exercise;neurobiological mechanism;Neuronal Plasticity;Neurons;Nonpharmacologic Therapy;Normalcy;older adult;Outcome;Participant;Pathway interactions;Patient Self-Report;Performance;Phenotype;Physical activity;physical inactivity;Positron-Emission Tomography;pre-clinical;prospective;Research;response;Risk;Risk Reduction;Rodent;Role;Stress;Structure;Synapses;tau-1;Testing;Time;Validity and Reliability;Work

PROJECT_TITLE: Mechanisms and Moderators of the Effects of Physical Activity in Preclinical Alzheimer Disease


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Biophysical, Topological, and Functional Studies of Endogenous Circular DNAs (PI: S.D. Levene) Project Narrative Circular DNAs, which are physically and topologically distinct from linear chromosomes, contribute to many biological activities including intercellular heterogeneity and, in particular, are associated with malignancies and chemotherapy-drug resistance. Understanding the structure and topology of these circular molecules, which distinguish them from linear-DNA counterparts, can lead to strategies targeting circular-DNA-specific properties. Thus, the study described in this application can provide valuable information to advance 21st– century therapies for cancer and personalized medicine.

PI_NAMEs: LEVENE, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Affinity;analog;Attention;Behavior;Biogenesis;Biological;Biological Assay;Biological Process;Biology;biophysical techniques;Biophysics;Cancer Biology;cancer cell;cancer therapy;Cells;chemotherapy;Chromatin;Chromatin Structure;Chromosomes;Circular DNA;Collaborations;Coupling;Data;Diagnosis;Diagnostic;Disease;DNA;DNA Sequence;DNA Structure;Drug resistance;Elasticity;Elements;Environment;Epigenetic Process;experience;experimental study;Explosion;fluorophore;Future;Gene Expression;gene therapy;Genes;Genetic;genetic analysis;Genetic Transcription;Genome;Genomic approach;Heterogeneity;Human;Human Cell Line;Human Engineering;In Vitro;in vivo;innovation;insight;Instruction;interest;Knowledge;Laboratories;Length;Link;Maintenance;Malignant Neoplasms;Methods;Modification;Molecular;Molecular Conformation;nanomechanics;next generation sequencing;Normal Cell;novel;Nucleic Acids;Nucleosomes;Organism;Outcome;personalized medicine;Physical Chemistry;Physiological;Plants;Play;Population;potential biomarker;Prevalence;programs;Property;Research;Research Personnel;Role;single molecule;Structure;System;Techniques;Testing;Therapeutic;tool;Training;tumor progression;Variant;Work

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Childhood Injury;Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE BPD remains the most common and severe complication of prematurity, in which innate immune mechanisms that may protect the lung are poorly understood. This project will identify unique gene regulatory networks of lung myeloid cells that support a regenerative immune response in the developing lung. These findings will elucidate novel pathways of neonatal lung resilience after hyperoxia, which will inform the development of more targeted management of multifactorial BPD.

PI_NAMEs: SAJTI, ENIKO  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Adult;Affect;Age;Air;Alveolar Macrophages;Apoptosis;Arbitration;Architecture;ATAC-seq;Binding;Birth Weight;Blocking Antibodies;Body System;Bronchopulmonary Dysplasia;cell injury;cell type;Cells;ChIP-seq;Chromatin;Chronic lung disease;Complex;Complication;Cre-LoxP;Data;Development;Disease;Disease susceptibility;DNA;Enhancers;Environment;Epigenetic Process;epigenomics;Epithelial Cells;Exposure to;Extremely Low Birth Weight Infant;Functional disorder;gene conservation;Gene Expression;Gene Modified;gene regulatory network;Genes;Genetic;Genetic Transcription;Goals;Harvest;Health;health care service utilization;Histology;Histone Acetylation;Human;Hyperoxia;hyperoxia induced lung injury;Immune;Immune response;in vivo;Individual;individual variation;Infant;Inflammatory;Inflammatory Response;inhibiting antibody;Injury;innate immune mechanisms;Innate Immune Response;Innate Immune System;insight;interstitial;Intervention;Intrinsic factor;Investigation;Life;loss of function;Lung;lung development;lung injury;lung regeneration;lung repair;Macrophage;Measures;Mediating;Modeling;Modification;monocyte;Mouse Strains;Mus;Myelogenous;Myeloid Cells;Neonatal Hyperoxic Injury;Neonatal lung;neonatal mice;neonatal period;new therapeutic target;novel;novel strategies;Outcome;Oxygen;Oxygen Therapy Care;Pathogenicity;Pathway interactions;Patients;personalized medicine;Play;Predisposition;premature;Premature Birth;Premature Infant;preservation;prevent;Prevention;programs;pulmonary function;Pulmonary Pathology;Randomized;receptor;Recovery;regenerative;Regulatory Pathway;repaired;Reporting;resilience;Resistance;respiratory health;Respiratory Signs and Symptoms;response;Role;Severities;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;sound;Stimulus;Supporting Cell;Survivors;targeted treatment;Testing;therapeutic target;therapy design;tissue injury;tissue regeneration;Tissues;TP53 gene;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;translational potential;TREM2 gene;Uterus;Wild Type Mouse;Work

PROJECT_TITLE: Role of neonatal lung macrophages in mediating resilience to hyperoxia induced lung injury via TREM2 signaling

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]