NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Osteoporosis;Patient Safety;Physical Activity;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: More than a million persons in the United States live with HIV, and as this population ages it shows an earlier than expected and growing prevalence of physical frailty, which carries substantial risk of falls and fractures as well as individual and societal costs. This project combines the analysis of large datasets and prior HIV model outputs with a computer simulation model of lifetime and economic consequences of HIV and physical frailty. It will establish the value of diagnosis and treatment strategies for physical frailty in persons living with HIV and comorbidities, to help inform the decisions of physicians and policy makers.

PI_NAMEs: LOSINA, ELENA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Age;Age Years;aging process;antiretroviral therapy;Attenuated;Body Weight decreased;Budgets;Cardiovascular Diseases;cardiovascular fitness;Cardiovascular system;Caring;Cessation of life;Chronic;Clinical;Clinical Management;comorbidity;Computer Simulation;Consequences of HIV;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Data;Diagnosis;disability;Economics;effective intervention;Effectiveness of Interventions;Epidemic;Exercise;exercise intervention;exercise program;experience;Exposure to;Fall prevention;fall risk;falls;Fatigue;Fracture;frailty;General Population;Goals;Guidelines;Hand Strength;Health Benefit;Hepatitis C co-infection;HIV;immune function;improved;Incidence;Individual;Infection;Inflammation;innovation;insight;interest;Intervention;intervention cost;Knowledge;large datasets;Life Expectancy;Medical Care Costs;Metabolic syndrome;Methodology;Methods;Modeling;models and simulation;multi-component intervention;multidisciplinary;Muscle function;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Opportunistic Infections;Osteoporosis;Outcome;Output;Persons;Pharmaceutical Preparations;Physical activity;Physical assessment;Physicians;Policies;Policy Analysis;Policy Maker;Polypharmacy;Population;Prevalence;prevent;Prevention program;Prevention strategy;programs;Quality-Adjusted Life Years;Recurrence;reduced muscle mass;Research;Resources;response;RNA;routine screening;sarcopenia;screening;Series;societal costs;Structure;Substance Use Disorder;Time;Tobacco;Tobacco use;Translating;Translational Research;treatment guidelines;treatment strategy;United States;walking speed;years of life lost

PROJECT_TITLE: HIV and musculoskeletal frailty: implications for care, policy and research


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Valley Fever

ORG_CITY: TEMPE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Coccidioidomycosis is an emerging disease of the American southwest where the economic impact exceeds 100 million dollars annually. Identifying new serological antigens will improve diagnostic paradigms to more effectively place patients into proper follow-up and prevent some of the severe sequalae due to dissemination.

PI_NAMEs: LAKE, DOUGLAS F.;MAGEE, D MITCHELL (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Absenteeism at work;accurate diagnosis;Activities of Daily Living;Acute;Acute Disease;aerosolized;American;Antibiotics;Antibodies;antibody detection;Antibody Response;Antibody titer measurement;antigen detection;Antigens;Area;Arizona;Bacterial Pneumonia;Biological Assay;Biological Markers;Blastomycosis;Blood Tests;bone;Bronchoalveolar Lavage;California;Categories;Chronic;clinical diagnosis;Cloning;Coccidioides;Coccidioidomycosis;community acquired pneumonia;Complement;Coughing;cross reactivity;desert fever;detection assay;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic strategy;Diagnostic tests;Disease;Dryness;economic impact;Elderly;Ensure;Enzyme Immunoassay;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;fabrication;follow-up;Fungal Spores;fungus;Growth;Health Personnel;Histoplasmosis;Illness Days;Immunoassay;Immunocompetent;Immunodiffusion;Immunoglobulin G;Immunoglobulin M;immunoreactivity;improved;Incidence;Individual;Infection;Inhalation;Laboratories;Laboratory Diagnosis;Learning;Life;Lung;Measures;Medical;Meninges;Micro Array Data;Morbidity - disease rate;mortality;Nucleic Acids;Patient Monitoring;Patients;Performance;Phase;Plasmids;Pneumonia;Population;Precipitins;Preparation;prevent;Printing;Procedures;Production;Prognosis;Protein Array;Protein Microchips;Proteins;Proteome;Publishing;Reaction;Recombinants;Reporting;Reproducibility;Reproduction spores;Resources;response;retiree;sample fixation;Sampling;Schools;screening;Sensitivity and Specificity;Serodiagnoses;Serology;Serology test;seropositive;Serum;Sick Leave;Site;Skin;Soil;Specificity;Sputum;Standardization;success;Surveys;Symptoms;System;Testing;Time;Translating;Tube;Tuberculosis;Validation;Viral;Viral Pneumonia

PROJECT_TITLE: Serological Biomarkers for Coccidioidomycosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-G(90)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Approximately 20-40% of patients with acute neurological illness hospitalized in a Neuroscience Intensive Care Unit (NICU) and their informal caregivers experience clinically significant emotional distress which becomes chronic, and is associated with worse recovery trajectory and overall quality of life. The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress. Through this study, we seek to solve the unmet need of preventing chronic emotional distress in NICU dyads through a feasible, acceptable and credible program, and ideally improve the recovery trajectory and dyads' overall quality of life.

PI_NAMEs: VRANCEANU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acute;Acute Brain Injuries;Adherence;Admission activity;Adult;Adverse effects;Anxiety;Attention;Caregivers;Chronic;Clinical;Clinical Data;clinical predictors;clinically relevant;clinically significant;Cognitive;comparison control;coping;Data;demographics;Diagnosis;Distress;Dose;Education;Educational process of instructing;effectiveness/implementation study;efficacious intervention;efficacy evaluation;efficacy outcomes;efficacy testing;efficacy trial;Electronic Health Record;Eligibility Determination;Emotional;emotional distress;emotional functioning;emotional symptom;Enrollment;ethnic diversity;Event;experience;follow-up;Funding;General Hospitals;Geography;Goals;Home;Hospitalization;Hospitals;improved;Individual;individual patient;informal caregiver;Infrastructure;Intensive Care Units;Interpersonal Relations;Intervention;Intervention Trial;Investigation;Manuals;Manuscripts;Massachusetts;Measures;Mediating;Mediation;Mediator;Medical;medical complication;member;Mental Depression;Methodology;mindfulness;mortality;multidisciplinary;Neurologic;Neurosciences;new technology;novel;Outcome;Participant;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pilot Projects;Placebos;Population;post-traumatic stress;post-traumatic symptoms;predicting response;prevent;primary caregiver;primary outcome;programs;promote resilience;Psychologist;psychosocial;Publishing;Quality of life;racial diversity;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;Research;resilience;resilience factor;response;Risk;Sample Size;Sampling;satisfaction;secondary outcome;Severity of illness;Single-Blind Study;Site;skills;Stress;Stroke;Surveys;Survivors;Team Nursing;Testing;Time;tumor

PROJECT_TITLE: Recovering Together: Building resiliency in dyads of patients with an acute brain injury admitted to the Neuroscience Intensive Care Unit and their informal caregivers

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Non-functioning kidney grafts after deceased-donor kidney transplantation remain a significant problem, with about one thousand grafts failing yearly and only 50% remain functional after ten years. The current tools we have to predict graft failure are limited in providing pathways for future intervention, therefore this project aims to identify if recipient protein markers involved in blood vessel stability are associated with future graft function in an effort to identify pathways amenable to intervention. The mission of this project aligns well with the overall mission of the NIDDK, as we aim to understand pathways that influence recipient graft outcomes to be able to enhance graft quality and improve overall recipient health.

PI_NAMEs: MANSOUR, SHERRY GEORGE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Albumins;Allografting;Angiopoietins;ANGPT1 gene;Animal Model;antagonist;antibody-mediated rejection;Atrophic;Biological;Biological Markers;Biopsy;Blood;Blood capillaries;Blood specimen;Blood Vessels;cadherin 5;career;cell injury;clinical care;clinical epidemiology;Clinical Research;cohort;Collection;Data;Development;Donor person;effective therapy;End stage renal failure;Endothelial Cells;Enrollment;Equilibrium;Evaluation;experience;Extravasation;Family;Fibrosis;Finding by Cause;Folic Acid;follow-up;Future;Glomerular Filtration Rate;Goals;graft failure;graft function;Health;Histologic;Histology;Hospitals;Human;Impairment;improved;Injury;interstitial;Intervention;Intervention Studies;ischemic injury;junctional adhesion molecule;Kidney;kidney allograft;kidney fibrosis;Kidney Transplantation;Learning;Measurement;Measures;Mediator;Mission;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;Organ;Organ Procurements;Outcome;participant enrollment;Pathology;Pathway interactions;Patients;Perioperative;Permeability;Plasma;Postoperative Period;Production;prognostic;Prognostic Marker;prospective;Prospective cohort;protein biomarkers;Protocols documentation;Recurrence;Renal function;repaired;Research;response;retransplantation;risk stratification;Role;Sampling;Stains;Structure;Testing;TIE-2 Receptor;Time;Tissue Banks;Tissue Grafts;Tissues;tool;Transplant Recipients;Transplantation;Tubular formation;Urine;Waiting Lists

PROJECT_TITLE: Evaluation of Angiopoietins as Prognostic Markers of Kidney Allograft Structure and Function

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This UNITE T32 training program at UNC Chapel Hill supports trainee development of those working at the interface of environmental biostatistics, environmental epidemiology and environmental health. The trainees develop critical thinking skills and learn how to use state-of-the-art methodologies to address urgent and critical needs in environmental health sciences as they arise. Our transdisciplinary approaches focus on: (1) cutting edge data science for environmental public health, (2) emerging contaminants due to changing climate and consumer products that threaten North Carolina and the world, and (3) environmental justice.

PI_NAMEs: ENGEL, STEPHANIE ;FRY, REBECCA  (contact);ZHOU, HAIBO

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Biometry;Environmental Health;Research

PROJECT_TITLE: Biostatistics for Research in Environmental Health


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pediatric obesity is an epidemic that is disproportionately experienced by children from lower socioeconomic backgrounds, underscoring the need to identify novel, modifiable risk factors for obesity prevention and treatment, particularly for those at greater risk. Mounting evidence rooted in circadian science suggests that the timing and consistency with which children engage in sleep, eating and activity behaviors may represent novel targets for enhancing existing prevention and treatment approaches with potential for high public health impact.

PI_NAMEs: HART, CHANTELLE NOBILE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 8 year old;Accelerometer;actigraphy;Adolescence;Adult;Affect;Behavior;Behavior assessment;behavior influence;Behavioral;Biological;Biological Process;Biological Rhythm;Body mass index;Child;circadian;circadian biology;circadian pacemaker;Circadian Rhythms;comorbidity;dietary;Disparity;Eating;Economics;energy balance;Enrollment;Ensure;Environment;Environmental Risk Factor;environmental stressor;Epidemic;excessive weight gain;experience;experimental study;Family;Food;food insecurity;food security;Future;Glucose;Habits;Health;Health behavior;health disparity;Height;Home;Hour;Household;improved;Intake;Light;low socioeconomic status;Measures;Melatonin;Metabolism;modifiable risk;Napping;neighborhood disadvantage;neighborhood safety;Neighborhoods;novel;novel strategies;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Observational Study;Patient Self-Report;Pediatric Research;Phase;Physical activity;Prevention;Public Health;Regulation;Research;Research Support;response;Risk;Risk Factors;Risk Reduction;Rodent;Rodent Model;Role;Schedule;School-Age Population;Science;Seasons;sedentary activity;Shapes;Sleep;sleep behavior;socioeconomic disparity;Socioeconomic Status;socioeconomics;Structure;Testing;therapy development;Time;Weight;Weight Gain;weight gain prevention;Work;Youth

PROJECT_TITLE: Behavioral and Biological Rhythms in Children's Obesity-Related Health Disparities


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Immunotherapy;Infectious Diseases;Neurosciences;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The overall mission of the DARE Collaboratory is to harness the power of the immune system to control HIV in the absence of antiretroviral therapy (a “remission”) or eliminate it during therapy (which if successful could lead to a complete “cure”). To address our first goal – developing an effective remission strategy – we will in develop a combination regimen that enhances the ability of CD8+ T cells and other parts of the immune system to target SIV/HIV immediately after therapy is interrupted. To address or second goad – reservoir reduction and elimination – we will develop drugs that render infected cells more susceptible to immune-mediated clearance mechanisms.

PI_NAMEs: DEEKS, STEVEN GRANT (contact);LEWIN, SHARON RUTH;PICKER, LOUIS J.

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;acute infection;adaptive immune response;Address;Aftercare;Animal Model;antagonist;Anti-Retroviral Agents;Antigens;antiretroviral therapy;Apoptotic;BCL1 Oncogene;Binding;Biological;CD8-Positive T-Lymphocytes;Cell Death;cell killing;Cell Survival;Cells;Cessation of life;Clinical;Clinical Trials;Clinical Trials Design;cohort;collaboratory;combinatorial;Cytomegalovirus Vaccines;design;Development;Disease remission;Event;Frequencies;Future;Genetic Transcription;Goals;Growth;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;Human;humanized mouse;Immune;Immune Evasion;Immune response;Immune system;Immunologics;Immunotherapy;In Vitro;in vitro Model;in vivo;Individual;Infection;Innate Immune Response;Intercept;Interruption;Investments;Lymphoid Tissue;Mediating;meetings;member;mimetics;Mission;Modeling;Monkeys;mouse model;Nature;nonhuman primate;Pathway interactions;Persons;Pharmaceutical Preparations;Population;preclinical development;Predisposition;prevent;programs;Proliferating;Proteins;Proviruses;Recrudescences;Regimen;Research;Research Design;Research Personnel;Residual state;Resistance;Resources;response;Sampling;Series;Signal Transduction;SIV;T cell response;T-Lymphocyte;Testing;Therapeutic;therapy development;treatment optimization;Viral;Viral Antigens;Viral Proteins;viral rebound;viral RNA;Viremia;Virus;Work

PROJECT_TITLE: Delaney AIDS Research Enterprise to Cure HIV


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative  Food allergy affects 6-8% of children and ~3% of adults the general population. Food allergy is mediated by antigen crosslinking of IgE antibody bound to mast cells (MC), and is often associated with intestinal dysbiosis. IgE sensitization to food is not sufficient by itself to drive food anaphylaxis. Intestinal MC load, which controls intestinal permeability and systemic antigen absorption, is an important determinant. DOCK8 deficiency is characterized by recurrent infections, eczema and food allergy with a high incidence of food anaphylaxis As food allergy and anaphylaxis are cardinal features of DOCK8-deficient patients, DOCK8 deficiency constitutes a disease model for identifying mechanisms underlying food allergy. We will test the hypothesis that DOCK8 deficient mice, which show increased susceptibility to anaphylaxis caused by food ingestion, have dysregulated immunity that results in an abnormal intestinal microbiome, which results in an increased intestinal MC load and exaggerated susceptibility to ingested antigens. We will examine whether the principles learned from studying food allergy in Dock8 deficiency are applicable to patients with food allergy. The results obtained. They may suggest novel for food allergic patients.

PI_NAMEs: GEHA, RAIF SALIM (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: absorption;Adult;Affect;Allergic;Anaphylaxis;anti-microbial peptide;Antibiotics;Antibodies;antigen challenge;Antigens;Automobile Driving;Binding;Cell Physiology;Cells;Child;crosslink;cytokine;disease model;DOCK8 deficiency;dysbiosis;Eczema;Enteral;Exhibits;fecal transplantation;Food;food allergen;Food Hypersensitivity;General Population;Genes;Germ-Free;Guanine Nucleotide Exchange Factors;gut microbiome;IgE;IL17 gene;Immune;Immunity;Incidence;Ingestion;interleukin-22;Interleukin-4;intestinal epithelium;Intestinal permeability;Intestines;Lamina Propria;Learning;mast cell;Mediating;microbiome;Molecular;Mouse Strains;Mus;novel;novel strategies;Oral;Outcome;passive sensitization;Patients;Phenocopy;Predisposition;Prevention strategy;Production;recurrent infection;Regulatory T-Lymphocyte;Role;Serum;Severities;Signal Transduction;Small Intestines;STAT3 gene;stool sample;T-Lymphocyte;Testing;Th2 Cells;Transgenic Mice;Tryptase

PROJECT_TITLE: Molecular and cellular mechanisms in food anaphylaxis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE We are developing a new generation of diverse young scientists who are broadly skilled with the latest tools of scientific excellence and rigor to be inquisitive and critical as they expand the frontiers of science. We are training these future leaders to be broadly cognizant of the potential of many different scientific careers.

PI_NAMEs: BLEMKER, SILVIA SALINAS (contact);KELLY, KIMBERLY A.

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Biotechnology;Training Programs

PROJECT_TITLE: Biotechnology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: EPITEL, INC.

ORG_STATE: UT

PHR: This grant proposal aims to create a digital health platform that includes a wearable medical device worn on the scalp below the hairline. The system detects and counts seizures, and alerts to seizures in real time. The goal is to empower people with epilepsy to take control of their seizure monitoring and help improve the treatment of epilepsy.

PI_NAMEs: LEHMKUHLE, MARK J. (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Admission activity;Adoption;Algorithms;Applications Grants;Artificial Intelligence;Auras;Awareness;Back;Behavioral;Bluetooth;Businesses;Cellular Phone;Charge;Clinical;cloud platform;commercialization;Communication;Community Hospitals;Consumption;Cues;Data;Data Collection;Data Set;design;Detection;detection platform;Development;Diagnosis;diaries;digital;digital health;effective therapy;Electroencephalography;Emergency Medicine;empowerment;encryption;Environment;Environmental Risk Factor;Epilepsy;Event;Family;Financial Hardship;Focal Seizure;Forehead;Freedom;Goals;Home;Hospitals;Hour;improved;Left;Life;Location;Machine Learning;machine learning algorithm;Manuals;Medical Device;Methods;Modeling;Monitor;Morphologic artifacts;Motion;motor impairment;multimodal data;multimodality;Neurologic;optimal treatments;Paper;Patient Self-Report;Patients;Periodicity;Persons;Phase;Physiological;Precipitating Factors;Predisposition;Probability;Process;programs;psychologic;Quality of life;remote monitoring;Reproducibility;Running;Scalp structure;Screening procedure;Secure;Seizures;sensor;Services;Sleep;social;standard of care;Subclinical Seizures;System;Time;transmission process;Uninsured Medical Expense;Validation;wearable device;wireless;wireless fidelity;Work

PROJECT_TITLE: Automated Seizure Detection for Home Seizure Monitoring with Epilog Sensors


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HUNTER COLLEGE

ORG_STATE: NY

PHR: Project Narrative – Public Health Significance Interventions such as Couples HIV testing and counseling (CHTC), which address HIV-risk within primary relationships, are an essential component to a comprehensive national prevention strategy. Up to two-thirds of HIV infections among MSM occur within the context of primary partnerships, and these rates are highest among younger men who have sex with men (aged 18-29). Despite its promise, the current CHTC protocol is limited in two ways. First, CHTC does not incorporate a focus on drug use – a well-established correlate of HIV infection risk among YMSM specifically. Second, CHTC provides limited guidance for formal communication skills training in instances where partners have substantial communication deficits. Building upon pilot research funded by DA036419, the proposed project seeks to evaluate the efficacy of the We Test intervention – which includes two adjunct CHTC components: a substance use module (SUM) and an assertive communication training (CT) video. A total of 240 YMSM couples will be enrolled equally across sites in New York City and Detroit. Couples will be randomized in a factorial design to receive CHTC as usual; CHTC + SUM; CHTC + CT; or CHTC+SUM+CT. Follow-ups will occur at 3-, 6-, 9-, and 12-months post intervention. Analyses evaluate the efficacy of the intervention components to reduce drug use, drug related problems, and HIV transmission risk. Secondary outcomes include syphilis infection, PrEP uptake, and binge drinking as well as qualitative intervention feedback.

PI_NAMEs: STARKS, TYREL J (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: 4-hydroxybutyric acid;Address;Age;aged;Agreement;AIDS prevention;Amphetamines;Assertiveness;Behavioral;binge drinking;Biological Assay;Biological Markers;Chlamydia;Chlamydia Infections;Clinical Virology;club drug;Cocaine;Communication;condomless anal sex;condoms;Counseling;Couples;Data;Data Analytics;delivery vehicle;design;Development;Drug usage;ecstasy;effectiveness/implementation trial;efficacy evaluation;efficacy testing;emerging adult;Enrollment;ethnic diversity;experience;Feedback;follow-up;Funding;Funding Agency;future implementation;Goals;Gonorrhea;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/STD;Human immunodeficiency virus test;implementation research;Individual;Infection;infection risk;innovation;Intervention;intervention delivery;intervention effect;Interview;Investments;Joints;Ketamine;Laboratory Research;Link;male couples;Marijuana;Measures;Mediating;Mediator;men;men who have sex with men;Methodology;multi-site trial;New York City;Nitrates;Participant;Patient Self-Report;Pharmaceutical Preparations;pilot test;Play;post intervention;pre-exposure prophylaxis;Prevention;Prevention strategy;Process;Protocols documentation;Provider;Public Health;Race;Randomized;Recording of previous events;recruit;Reporting;Research;Resources;Risk;Risk Behaviors;Role;Sampling;Science;secondary outcome;Services;sex;sexual HIV transmission;Site;skills;skills training;Structure of nail of finger;substance use;Syphilis;Testing;theories;Training;transmission process;Treatment Efficacy;United States National Institutes of Health;uptake;Viral Load result;Work;young men who have sex with men

PROJECT_TITLE: Expanding the potential of couples HIV testing: Adjunct modules to reduce drug use among vulnerable male couples


NIH_SPENDING_CATS: Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The goal of this project, developed in partnership with Chicago Public Schools and the Boys & Girls Clubs of Chicago, is to develop a new, efficient approach for training and supporting elementary K-5 science teacher leaders well-versed in Next Generation Science Standards (NGSS) pedagogy, leadership, coaching, and evaluation skills. This project, “ESTELE: Developing the Next Generation of Science Teacher Leaders,” uses an authentic. practicum-based training strategy where teacher leaders coach and support new-to-NGSS teachers working in a community-based youth summer camp. Through this approach, science teacher leaders are prepared for school-level NGSS coaching and leadership roles, novice NGSS teachers gain valuable NGSS pedagogical skills, and hundreds of disadvantaged youths receive high-quality health- and science-focused summer learning.

PI_NAMEs: KENNEDY, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Acceleration;Acute;Affect;Age;Agreement;Area;Biological Sciences;boys;career;Chicago;Collaborations;college;Communities;community partnership;Country;Decentralization;design;Development;Disadvantaged;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational Status;Effectiveness;Elements;Environment;Evaluation;experience;Funding;Future;girls;Goals;Health;Healthcare;Hour;improved;innovation;Instruction;K-12 Faculty;K-12 student;Knowledge;Leadership;Learning;Location;Low income;mathematical learning;Mathematics;Mentors;minority children;Modeling;next generation;Next Generation Science Standards;Pathway interactions;pedagogy;peer;Population;Preparation;Primary School Faculty;Program Development;programs;Reading;Research;Resources;Risk;Role;role model;school district;Schools;Science;science teacher;Science, Technology, Engineering and Mathematics;skills;Societies;STEM career;Students;teacher;Teacher Professional Development;Teaching Method;Testing;third grade;Time;Training;Underrepresented Populations;United States National Institutes of Health;urban school;virtual;Work;Youth

PROJECT_TITLE: ESTELE: Developing The Next Generation Of NGSS Elementary Science Teacher Leaders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Both genetic and environmental risk factors play a part in the development of autism, yet despite being estimated to account for 41% of autism risk, we know very little about what environmental factors contribute to autism risk. Because social deficit is one of the 3 core symptoms of autism, I developed a high-throughput screening approach to systematically search for chemicals that inhibit the development of social behavior. This screen revealed topoisomerase II as a key regulator of the development of social behavior in zebrafish and mouse, which is investigated in further detail in this proposal.

PI_NAMEs: GENG, YIJIE  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Affect;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Binding;Biochemical;Biological;Brain;Chemicals;conditional knockout;Defect;Development;Developmental Gene;DNA;DNA Methylation;DNA methyltransferase inhibition;DNA Modification Methylases;DSM-V;Embryo;Embryonic Development;Environmental Risk Factor;Epigenetic Process;Etiology;Exposure to;gain of function;Gene Expression Regulation;Genetic;genetic risk factor;Genomics;Goals;Grant;Heterozygote;high throughput screening;Human;Investigation;Libraries;Link;Literature;loss of function;Methods;mouse model;Mus;Mutation;Names;National Institute of Environmental Health Sciences;new therapeutic target;overexpression;Pathway interactions;PHD Finger;Phenocopy;Phenotype;Play;postmitotic;prenatal exposure;prevent;Protein Isoforms;Regulation;repetitive behavior;Ring Finger Domain;Risk;Rodent Model;Role;screening;small molecule libraries;social;Social Behavior;social communication impairment;social deficits;Social Development;Social Responsibility;Stress;System;Techniques;Testing;Tissues;TOP2A gene;Topoisomerase II;Topoisomerase II inhibition;Topoisomerase-II Inhibitor;Ubiquitin;Zebrafish

PROJECT_TITLE: A systematic study of the environmental etiology of autism spectrum disorder using high-throughput behavioral screening

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Spread of cancer cells into the spinal fluid, or leptomeningeal metastasis, is a cruel complication of cancer that results in rapid neurologic disability and death. We understand little about the mechanisms that allow cancer cells to grow with the spinal fluid. To remedy this, we propose a bench-to-bedside approach combining state-of- the-art analyses of clinical samples with rigorous, hypothesis-driven mouse modeling.

PI_NAMEs: BOIRE, ADRIENNE A. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;analytical method;bench to bedside;Bioinformatics;Biological Assay;Biological Models;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Cell Growth;cancer complication;Cd68;cell growth;Cell Survival;Cells;Cerebrospinal Fluid;Cessation of life;Citric Acid Cycle;Clinical;Clinical Management;clinically relevant;Coculture Techniques;Collection;Complication;Coupled;cytokine;Data;Data Set;Dedications;design;Development;Disease;Disease Progression;Dissection;Environment;Flow Cytometry;functional adaptation;Future;gain of function;Gene Expression Profile;gene product;Genes;Genetic Epistasis;Genetic Transcription;Growth;Growth Factor;Health;human disease;Hypoxia;immune cell infiltrate;Immunologics;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo evaluation;Inflammatory;inflammatory milieu;instrument;interest;Iron;iron metabolism;Knowledge;Leptomeninges;Lipids;loss of function;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediator;Metabolic;Metabolic Pathway;metabolome;metabolomics;Metastatic Neoplasm to the Leptomeninges;Metastatic to;Modernization;Molecular;Molecular Profiling;mouse model;multimodality;Myeloid Cells;Natural Immunity;Neurological disability;novel strategies;Nutrient;Nutritional;Oxygen;Pathway interactions;Patients;Plasma;Population;pressure;Proteins;Proteome;Proteomics;PTPRC gene;Reporter;Research;Respiratory Burst;RNA;Sampling;Signal Transduction;single-cell RNA sequencing;Site;small molecule;System;Techniques;Technology;Testing;therapeutic target;transcriptome;transcriptome sequencing;translational approach;treatment strategy;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Investigating Microenvironmental Interactions in Leptomeningeal Metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Project Narrative Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance use disorders lead to impairments in these same cognitive processes. Recent large-scale research initiatives in forensic settings by our research team have begun to identify substance abuse and psychopathy- related disruption in the neural mechanisms involved in moral decision-making processes, and associations between these neural networks and future relapse and antisocial behavior. Here we extend our prior work (with incarcerated men) to examine these issues among incarcerated women in order to better understand sex differences. This project addresses the overall lack of neurocognitive research in criminal offenders with substance use disorders, thereby focusing on a major public health issue in an underserved and understudied population.

PI_NAMEs: KIEHL, KENT A (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Address;Amphetamines;Amygdaloid structure;Anatomy;Anterior;anti social;antisocial behavior;Antisocial Personality Disorder;Area;Award;Basal Ganglia;behavior test;Biological;Biological Markers;Borderline Personality Disorder;Brain;Cocaine;Cognition;cognitive process;Cognitive Therapy;Communities;comorbidity;Consultations;Corpus Callosum;cost;Data;Data Set;Decision Making;density;design;Diffusion;Dorsal;Drug abuse;Emotional;Ensure;Equipment;Etiology;Female;Forensic Medicine;frontal lobe;Functional disorder;functional MRI scan;Future;gender difference;gray matter;Health;high risk;high risk population;High Risk Woman;Image;Impairment;Imprisonment;improved;independent component analysis;Individual Differences;interest;Intervention;Lead;Linguistics;Magnetic Resonance Imaging;men;Mental disorders;Mental Health;Methamphetamine;Mindfulness Training;Modeling;Morals;Multimodal Imaging;multimodality;National Institute of Drug Abuse;Nature;neural circuit;neural network;Neuroanatomy;Neurobiology;Neurocognitive;neuromechanism;novel;offender;Outcome;Participant;Pathologic;Pathway Analysis;Pattern;Personality;Personality Traits;Pharmaceutical Preparations;Physiologic pulse;Population;Prediction of Response to Therapy;predictive modeling;Prisons;Process;programs;Psychopath;psychopathic personality;Public Health;Published Comment;Publishing;Relapse;relapse prediction;Request for Applications;Research;Resources;response;Sampling;Severities;sex;Sex Differences;Social outcome;Stimulant;stimulant abuse;stimulant use;Substance abuse problem;Substance Use Disorder;System;Task Performances;Temporal Lobe;Testing;Time;trait;Treatment outcome;treatment strategy;United States National Institutes of Health;white matter;Woman;Work

PROJECT_TITLE: Neurocognitive Abnormalities in Stimulant Abuse among High-Risk Women

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Recovery Support Services;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE There are few proven interventions that support parenting and long-term recovery for pregnant and postpartum women with Opioid Use Disorders (OUD). Using a community-based participatory research approach, the feasibility and preliminary effects of using a customized evidence-based digital technology self-management recovery program for women with OUD during the pregnancy and postpartum period will be evaluated. The findings from the proposed research will support the development of a targeted and cost-effective digital intervention to improve mother and infant outcomes for this vulnerable population.

PI_NAMEs: RAYNOR, PHYLLIS ANN (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Acute;addiction;Address;Adopted;Age;Award;Behavioral;Caring;Cessation of life;Child;Child Custody;Child Rearing;Child Welfare;Chronic;Collaborations;community advisory board;community based participatory research;cost;cost effective;Data;design;Development;digital;digital intervention;digital technology;Disputes;drug abstinence;Drug usage;evidence base;Evidence based program;feasibility testing;Female;Female of child bearing age;Fright;Future;Goals;Health;health care delivery;Health Services Accessibility;Healthcare;help-seeking behavior;HIV;Hospital Costs;Imprisonment;improved;Individual;Infant;infant outcome;infection risk;Insurance;Intervention;intervention program;K-Series Research Career Programs;Knowledge;Legal;Life;Location;long term recovery;Maternal complication;maternal outcome;Mediation;Medicaid;member;Mental Health;Mentors;Mothers;Neonatal;Neonatal Abstinence Syndrome;new technology;Newborn Infant;Not Hispanic or Latino;opioid use;opioid use disorder;Outcome;Outpatients;parent project;parenting intervention;Participant;patient oriented;Patients;Perception;Pharmacotherapy;Population;population health;Positioning Attribute;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prescription opioid;Prevalence;Privatization;Process;Program Evaluation;programs;Recovery;Recovery Support;reproductive;Research;Research Methodology;Research Training;Resources;Rural;rural health disparities;Self Care;Self Management;Site;skills;smartphone application;social stigma;Substance Use Disorder;substance use treatment;Syphilis;Technology;therapy development;Time;Training;transmission process;Transportation;unborn child;Vulnerable Populations;White Women;Woman;women's outcomes

PROJECT_TITLE: P.A.R.E.N.T.S.S Project -  Parents Adopting Recovery-management through Enhanced New Technology for Self-care and Support (for Mothers)

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Reduced shoulder mobility caused by prolonged joint immobilization, trauma, or surgical procedures is painful and debilitating. Current pharmacological and surgical treatment options for patients suffering from shoulder arthrofibrosis, or “frozen shoulder,” are limited in scope and effectiveness, resulting in many patients never regaining full joint function. The sustained and localized delivery of the antifibrotic peptide hormone, relaxin-2, is described as a novel solution to treat the underlying causes of shoulder contracture and to restore joint range of motion.

PI_NAMEs: GRINSTAFF, MARK W. (contact);KRUSE, ANDREW ;NAZARIAN, ARA

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adhesions;Adrenal Cortex Hormones;Adult;Anesthesia procedures;Animals;Ankle;Articular Range of Motion;Binding;biocompatible polymer;biodegradable polymer;Biological Markers;Caring;cartilaginous;Cell Physiology;Cells;Characteristics;Childbirth;Chondrocytes;Collaborations;Collagen;Contracture;Cryoelectron Microscopy;crystallinity;Cyclic GMP;cyclooxygenase 1;cytotoxicity;Data;Deposition;diabetic;Disease;Down-Regulation;Drug Kinetics;Effectiveness;Encapsulated;Engineering;Experimental Designs;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Formulation;Freezing;G-Protein-Coupled Receptors;Gene Expression;Glucocorticoid Receptor;Hip region structure;Histologic;Hormones;Human;Immobilization;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Injections;innovation;Intra-Articular Injections;joint function;joint stiffness;Joint structure of shoulder region;Joints;Kinetics;Knee;knock-down;Ligaments;Ligands;Manuscripts;Matrix Metalloproteinases;Measures;Medical;member;Modeling;Molecular;Molecular Weight;Myofibroblast;Nerve;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Operative Surgical Procedures;optimal treatments;Pain;particle;Particle Size;Pathway interactions;Patients;Pelvis;peptide hormone;Peptides;pharmacologic;Phenotype;Physical therapy;Polymers;Population;Pregnant Women;Preparation;Prevalence;Procedures;Property;Proteins;PTGS2 gene;Publishing;receptor;Regulation;Relaxin;restorative treatment;Risk;Serum;Shoulder;Signal Induction;Signal Pathway;Signal Transduction;Small Interfering RNA;small molecule;Structure;Symphysis pubis structure;Symptoms;Synovial Fluid;targeted treatment;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;Trauma;United States;Uterus;Variant;Western Blotting;Wrist

PROJECT_TITLE: Sustained Release Relaxin-2 for the Treatment of Frozen Shoulder

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: ECLIPSE LIFE SCIENCES, INC.

PHR: PROJECT NARRATIVE The goal of this project is to develop a novel eye injection treatment for dry age-related macular degeneration (AMD). In dry AMD, vision loss occurs due to formation of abnormal deposits of fat and proteins under the retina (drusen) and atrophy of retinal tissue over time. There are no approved therapies for dry AMD. One major cause of AMD is damage to mitochondria, the energy factories within our cells. This project will develop a new drug designed to repair damaged mitochondria, which in turn, may slow disease worsening and improve vision in patients suffering from dry AMD.

PI_NAMEs: COUSINS, SCOTT WILLIAM (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;advanced disease;Affect;Age related macular degeneration;Alcohols;Applications Grants;Atrophic;Biochemical;Biological Availability;Biological Response Modifier Therapy;Biological Sciences;Blindness;Bolus Infusion;Cells;Clinical Research;Clinical Trials;Deposition;design;Disease;Dose;Drug Delivery Systems;Drug Design;Drug Kinetics;Drug Targeting;Drusen;Dryness;effective therapy;efficacy study;Elderly;Esters;Eye;Fatty acid glycerol esters;Formulation;geographic atrophy;Goals;good laboratory practice;Good Manufacturing Process;Growth;improved;In Vitro;in vivo;in vivo Model;Injections;intravitreal injection;Investigational Drugs;Lead;Link;Lipids;luminance;Macular degeneration;manufacture;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Nonexudative age-related macular degeneration;novel;novel therapeutics;off-patent;open label;Organelles;Oryctolagus cuniculus;Patients;Penetration;Pharmaceutical Preparations;Phase;Photoreceptors;Pigment Epithelium;polyarginine;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;Preparation;Prodrugs;Production;Proteins;Reading;repaired;Research;response;Retina;Schedule;Small Business Innovation Research Grant;small molecule;Specific qualifier value;subcutaneous;Superoxides;targeted treatment;Therapeutic;Time;Tissues;Toxicology;Vision;Visual Acuity

PROJECT_TITLE: Mitochondrial-Targeted Therapy for Macular Degeneration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

ORG_CITY: KANSAS CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The proposed research will characterize a chemokine receptor inhibitor therapy to mitigate radiation injury and inflammation with efficacy at 24 hours after radiation exposure. This proposal will also define the mechanism of action of the countermeasure which will provide data necessary for product licensure requirements according to the FDA Animal Rule. Successful completion of this project will lead to the development of this chemokine receptor inhibitor-based therapy as a new medical countermeasure to treat injuries resulting from a radiation or nuclear accident.

PI_NAMEs: DIPAOLO, RICHARD J;PERRY, JOHN MARK;SAHA, SUBHRAJIT  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Acute;Affect;Aftercare;animal old age;animal rule;Animals;antagonist;Anti-Inflammatory Agents;Antineoplastic Agents;Atherosclerosis;B-Lymphocytes;Basophils;Bone Marrow;Bone Marrow Involvement;Cell Lineage;Cells;chemokine;chemokine receptor;Circulation;Data;Development;Disease;Dose;Early treatment;effector T cell;experimental study;Exposure to;Extramedullary;Face;FOXP3 gene;gastrointestinal;Gene Deletion;Hematopoietic;Hour;Human;Immune;Immune response;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;inhibitor therapy;injured;Injury;intestinal injury;Intestines;irradiation;juvenile animal;Knockout Mice;Licensure;Lung;Lymphocyte;mass casualty;medical countermeasure;Modeling;monocyte;mouse model;multiorgan damage;Multiple Organ Failure;Mus;Myelogenous;Myeloid Cells;Nuclear;Nuclear Accidents;Organ;Peritoneal Macrophages;pharmacologic;Play;Population;programs;Pulmonary Fibrosis;Radiation;Radiation Accidents;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;radiation resistance;Radiation Syndromes;Radiation Toxicity;radioresistant;recruit;Regulatory T-Lymphocyte;repair function;Research;Resistance;Rheumatoid Arthritis;Risk;Role;Schedule;Signal Transduction;Site;Structure of parenchyma of lung;Surface;Syndrome;T memory cell;T-Lymphocyte;Terrorism;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;tissue repair;Tissues;Toxic effect;trafficking;Whole-Body Irradiation

PROJECT_TITLE: Modulation of chemokine signaling to mitigate radiation induced inflammation


ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE This MIRA application combines projects supported by R01s GM124434 and GM126033. The project employs genetic and genomics tools in Drosophila and human cells to determine how cell growth and growth factor signaling are regulated, and how they in turn regulate cell proliferation. This work will uncover genes and regulatory mechanisms relevant to a broad range of human diseases that involve dysregulated cell proliferation, including degenerative diseases, chronic inflammatory diseases, and cancers.

PI_NAMEs: EDGAR, BRUCE ALEXANDER (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Animals;ATAC-seq;Autoimmune Diseases;Back;Binding;Biogenesis;Catalogs;CCNE2 gene;CDC45L gene;Cell Cycle;Cell Cycle Progression;Cell division;cell growth;cell growth regulation;Cell Proliferation;Cells;Cellular biology;chronic inflammatory disease;clinically relevant;combat;Complex;Coupled;cytokine;Degenerative Disorder;Developmental Biology;Diagnosis;Disease;DNA biosynthesis;Drosophila genus;E2F transcription factors;Enterocytes;Epidermal Growth Factor Receptor;Epithelium;FRAP1 gene;gastrointestinal epithelium;Gene Targeting;Genes;Genetic;genetic approach;Genomic approach;genomic tools;Grant;Growth;Growth Factor;Human;human disease;in vivo;Infection;Inflammation;Inflammatory;Insulin;intestinal epithelium;Intestines;Malignant Neoplasms;Metabolic;Metabolism;Mitochondria;mRNA Translation;National Institute of General Medical Sciences;Natural regeneration;novel strategies;Organoids;PIK3CG gene;Prevention;regenerative;Regenerative response;Research;Research Support;Resources;response;RNA Interference;Signal Transduction;stem cells;Stress;Testing;Tissue Engineering;Tissues;transcriptome sequencing;Translating;translation factor;Work

PROJECT_TITLE: Regulation of cell growth and proliferation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

PHR: This proposal will establish the extent to which retrieval constitutes a control-independent internal attention state. The results are expected to advance understanding of how the retrieval state may drive the processes and representations that support memory and cognition. In so doing, this proposal will provide a foundation for under- standing and identifying memory performance deﬁcits across the lifespan in healthy individuals and in patients suffering from cognitive impairments due to stroke or disease.

PI_NAMEs: LONG, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Accounting;Attention;attentional modulation;Behavior;behavior influence;behavioral outcome;Brain;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;Cues;Data;directed attention;Disease;Electroencephalography;Episodic memory;Event;Failure;Familiarity;flexibility;Foundations;Future;Goals;healthy aging;Impaired cognition;indexing;Individual;Instruction;Knowledge;Learning;life span;Link;Maintenance;Measures;Memory;memory encoding;Memory impairment;memory process;memory retrieval;millisecond;Modeling;neural;novel strategies;operation;Outcome;Patients;Pattern;Performance;Process;programs;Property;Research;Retrieval;Scalp structure;Semantics;sensory stimulus;Short-Term Memory;Stimulus;stimulus processing;Stroke;Testing;theories;Time;Work

PROJECT_TITLE: Multivariate Decoding of the Retrieval Brain State Across Cognition

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This proposal, “Research Training in Biobehavioral Disturbances of Eating Disorders,” requests support for a three-year research fellowship program for post-doctoral MD and PhD scientists to train much needed future researchers specializing in eating disorders. Eating disorders are medically and psychiatrically serious illnesses in critical need of research into their underlying mechanisms and potential treatments. The training program outlined in this application describes a plan to successfully train clinical researchers in this specialized area.

PI_NAMEs: ATTIA, EVELYN  (contact);WALSH, B. TIMOTHY

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY


ORG_NAME: YALE UNIVERSITY

PHR: Project narrative We propose a deep interrogation and a systems approach that will identify molecular signatures to vaccination across three cohorts of vulnerable patient populations that share a dysregulated inflammatory milieu: autoimmune patients treated with B cell depletion therapy, aged and frail individuals, and patients with sickle cell disease.

PI_NAMEs: HAFLER, DAVID A.;MONTGOMERY, RUTH R (contact)

PROJECT_TERMS: Adjuvant;Age;aged;Autoimmune;B cell therapy;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Benchmarking;Biological Assay;Blood;Blood Cells;cell type;Cells;Clinical;Clonal Expansion;cohort;Cohort Studies;Collaborations;Coupled;COVID-19 vaccine;Critical Pathways;Cytometry;Data Analyses;data integration;Development;dimensional analysis;Dose;draining lymph node;effectiveness evaluation;Elderly;Goals;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunologic Markers;Immunologics;Immunology;Immunophenotyping;Individual;Inflammatory;inflammatory milieu;Influenza vaccination;influenza virus vaccine;Infrastructure;Investigation;Knowledge;Link;lymph nodes;Mass Spectrum Analysis;Mathematics;Methods;MF59;Molecular Profiling;Multiomic Data;new technology;novel;novel vaccines;Pathway interactions;patient population;Patients;Phenotype;Physicians;Polyvalent pneumococcal vaccine;Population;Productivity;programs;Proteins;Proteomics;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;RNA vaccine;Scientist;Serum;Services;sharing platform;Sickle Cell Anemia;Signal Transduction;single cell analysis;single cell technology;single-cell RNA sequencing;Skin;Specificity;Standardization;success;System;T-Cell Receptor;Techniques;Therapeutic;Time;Tissues;tool;transcriptome;transcriptomics;Vaccination;vaccine effectiveness;vaccine formulation;vaccine immunogenicity;vaccine response;Vaccines;Vulnerable Populations

PROJECT_TITLE: Immune signatures of vaccine responses in vulnerable populations


NIH_SPENDING_CATS: Immunization;Vaccine Related

PI_NAMEs: MONTGOMERY, RUTH R (contact)

PROJECT_TERMS: Address;Advisory Committees;Communication;Consultations;cost effective;Data;data repository;data sharing;Data Storage and Retrieval;Decision Making;Ensure;Goals;Human;Immune;Immunology;Institution;Intellectual Property;meetings;Monitor;Publications;Research;Research Project Grants;Resources;success;Technology;vaccine response;Vulnerable Populations

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Services;Hematology;Immunization;Immunotherapy;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Primary Health Care;Rare Diseases;Sickle Cell Disease;Vaccine Related

PI_NAMEs: SHAW, ALBERT C (contact)

PROJECT_TERMS: 21 year old;Adherence;Adjuvant;Adult;Age;anti-CD20;Archives;Assisted Living Facilities;Autoimmune;Autoimmune Diseases;Autoimmunity;Axillary lymph node group;B cell therapy;B-Lymphocytes;Bar Codes;Bioinformatics;Biological;Blood;Bulla;Chronic;Clinic;Clinical;Code;Collaborations;Connecticut;Consent Forms;Control Groups;COVID-19 booster;COVID-19 vaccination;COVID-19 vaccine;Data Analyses;data management;Data Management Resources;Data Security;Databases;Dermatology;design;Disease;Dose;draining lymph node;electronic data;Enrollment;Ensure;experience;Generations;Geriatrics;Goals;Health system;Human;human old age (65+);human subject;Human Subject Research;human tissue;Immune;Immune response;Immunization Programs;Immunological Models;Immunologics;Immunology;Individual;Inflammation;influenza pneumonia;Influenza vaccination;influenza virus vaccine;Informed Consent;Investigation;lymph node biopsy;Maps;Measures;MF59;Multiple Sclerosis;Neurology;novel;Nursing Homes;older adult;Older Population;open label;Participant;participant enrollment;Patient Recruitments;Patients;Physician Executives;Physicians;Pilot Projects;Polyvalent pneumococcal vaccine;Preparation;Primary Care;primary care patient;Procedures;programs;Protocols documentation;Randomized;randomized trial;recruit;Research;Research Personnel;Research Project Grants;Resources;response;Retrieval;Safety;Sampling;Scientist;screening;Secondary Immunization;Services;Sickle Cell Anemia;Site;Skin;skin biopsy;Source;Splenectomy;Streptococcus pneumoniae;System;Tissues;transcriptomics;Vaccination;vaccine response;Vaccines;Vulnerable Populations;young adult

PROJECT_TITLE: Clinical subjects and recruitment


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Immunization;Precision Medicine;Prevention;Vaccine Related

PROJECT_TERMS: Adaptive Immune System;Antibodies;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;Bar Codes;Biological Assay;biomarker discovery;Biopsy;Blood;Blood Cells;Blood specimen;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Circulation;Clinical;clinically relevant;Clonal Expansion;cohort;Cohort Studies;Collaborations;comparative;Complex;computerized tools;Cytometry;Data;Data Analyses;data integration;data management;data repository;Detection;dimensional analysis;Dimensions;Disease;feeding;Frequencies;functional status;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Heavy Metals;high dimensionality;human disease;Immune;immune function;Immune response;Immunologic Markers;immunological status;Immunologics;Immunophenotyping;Innate Immune System;insight;interest;Investigation;Ions;Knowledge;Label;lymph nodes;Manuals;Maps;Mass Spectrum Analysis;Measurement;Membrane Proteins;Messenger RNA;Molecular;Molecular Profiling;multiple omics;National Institute of Allergy and Infectious Disease;new technology;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Process;protein expression;Proteins;Proteome;Proteomics;Quality Control;Reproducibility;Research Project Grants;Resolution;Resources;response;response biomarker;Sampling;Serum;Services;sharing platform;Signal Pathway;Signal Transduction;single cell analysis;single cell technology;Site;Skin;Specificity;Standardization;study population;T-Lymphocyte;Technology;Time;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;unsupervised clustering;Vaccination;vaccine immunogenicity;vaccine response;Vaccines;Visualization;Vulnerable Populations;Weight

PROJECT_TITLE: Multi-omic immune profiling


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: HAFLER, DAVID A. (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Adenoviruses;Adjuvant;Affect;Age;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;antigen challenge;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Attenuated;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B cell therapy;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Blood;BLR1 gene;Cell Communication;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;cohort;COVID-19 booster;COVID-19 mortality;COVID-19 patient;COVID-19 vaccination;Custom;Dendritic cell activation;Disease;Dose;draining lymph node;Elements;Event;Exhibits;extracellular;flu;Frequencies;Generations;genetic signature;Hemagglutinin;HLA-DR Antigens;Immune;Immune response;Immunity;Immunization;Impairment;improved;Individual;Influenza;influenza virus vaccine;Investigation;investigator-initiated trial;lipid nanoparticle;lymph nodes;Measures;Messenger RNA;Methodology;MF59;nanoparticle;novel;Oligonucleotides;Outcome;pathogenic autoantibodies;Pathogenicity;Patients;Peptides;Peripheral;Pharmaceutical Preparations;Phenotype;Plasmablast;Play;Production;programmed cell death protein 1;Proteins;Proteomics;Protocols documentation;Recovery;response;RNA vaccination;RNA vaccine;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Secondary Immunization;sensor;Severe Acute Respiratory Syndrome;sex;single-cell RNA sequencing;Site;Skin;System;Systems Analysis;T cell response;T-Lymphocyte;Technology;Time;transcriptomics;Vaccination;vaccine immunogenicity;vaccine response;vaccine strategy;Vaccines;vector vaccine;Viral;Viral Vaccines;Viral Vector;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Systems investigation of vaccine responses in B cell depleted autoimmune patients


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Health Services;Human Genome;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Adjuvant;Adult;Affect;age effect;age related changes;Aging;anti-influenza;Antibodies;Antibody Response;Antigens;Appearance;Architecture;B-cell receptor repertoire sequencing;Biological Models;Biological Response Modifier Therapy;Blood Platelets;Boston;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Clinical Trials;Collaborations;Color;Communities;COVID-19;COVID-19 outbreak;COVID-19 pandemic;Cryoelectron Microscopy;cytokine;Dendritic Cells;Disease;Disease Outbreaks;Dose;draining lymph node;Enrollment;Epitope Mapping;Flow Cytometry;frailty;Functional impairment;functional status;Future;Gene Expression;Gene Expression Profile;Genetic;genetic signature;Geriatrics;High Prevalence;Home;Hospitalization;Human;human old age (65+);human subject;Immune;immune activation;Immune response;Immunoglobulins;Immunologics;Immunology;In Vitro;Incidence;Individual;Infiltration;Inflammasome;Influenza;Influenza A Virus, H3N2 Subtype;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus vaccine;Infrastructure;innovation;insight;Investigation;Laboratories;lymph node biopsy;Mediating;Memory B-Lymphocyte;MF59;monocyte;Morbidity - disease rate;mortality;mouse model;Natural Immunity;new pandemic;novel;Nursing Homes;older adult;pandemic disease;pandemic influenza;Participant;Pathway interactions;Patients;Pattern recognition receptor;Pediatric Hospitals;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Physician Executives;Pneumonia;Population;Prevention;Primary Care;Production;programs;prospective;Proteins;proteomic signature;Proteomics;Public Health;Randomized;receptor function;Receptor Signaling;recruit;Regulation;Relaxation;Reporting;respiratory;Respiratory Tract Infections;response;Risk;Sampling;Seasons;secondary lymphoid organ;Serum;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;skin biopsy;System;T-Lymphocyte Subsets;targeted treatment;Tissues;Toll-like receptors;transcriptomics;United States;Vaccination;vaccine effectiveness;vaccine response;vaccine trial;vaccine-induced antibodies;Vaccines;Viral;Viral Respiratory Tract Infection;Virus Diseases;Visualization;Vulnerable Populations;ward;Work;young adult

PROJECT_TITLE: Systems investigation of vaccine responses in aging and frailty


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Exosomes and their cargo RNAs have been shown to play a role as novel signaling entities and may serve as a new class of markers in heart failure patients. In this proposal, we seek to validate and improve the performance of these RNA biomarkers, study how they regulate cellular processes important in progression of heart failure and develop new therapies to interrupt this disease. We expect our work will yield new insight into the biology of heart failure, develop clinically actionable markers and provide a platform for new types of therapy.

PI_NAMEs: DAS, SAUMYA  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Address;Area;Arrhythmia;Autophagocytosis;biobank;Biological Markers;Biology;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cell Culture Techniques;Cell Physiology;Cells;Cessation of life;Clinical;clinical biomarkers;clinically actionable;Complex;Diagnosis;Disease;exosome;experimental study;extracellular;extracellular vesicles;Fibrosis;flexibility;Grant;Health Expenditures;Heart failure;Heart Hypertrophy;high reward;high risk;Hospitalization;Human;improved;induced pluripotent stem cell;insight;intercellular communication;Interruption;Ischemia;Measures;Mediating;Mentors;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;next generation;novel;novel therapeutics;Nuclear;organ on a chip;Pathogenesis;Patients;Performance;Phenotype;Plasma;Prevalence;Process;prognostic;Research;Research Personnel;risk stratification;RNA;Role;Sampling;Signal Pathway;Signal Transduction;small molecule;therapeutic siRNA;therapeutic target;Time;Tissues;tool;transcriptome sequencing;United States;uptake;vesicular release;Work

PROJECT_TITLE: Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failure


NIH_SPENDING_CATS: Aging;Biotechnology;Chronic Pain;Clinical Research;Genetics;Hematology;Immunization;Orphan Drug;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease;Vaccine Related

PROJECT_TERMS: Acute;adaptive immunity;Adjuvant;Affect;African American population;Age;Aging;Amino Acid Substitution;Antibodies;Appearance;B-Lymphocytes;beta Globin;Biological Assay;Blood Platelets;Blood specimen;Bone necrosis;Cell Lineage;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Clinical;cytokine;Data;Data Analyses;data management;Data Set;Development;Enzyme-Linked Immunosorbent Assay;Erythrocyte Membrane;flu;Frequencies;Functional disorder;Gene Expression;Genetic;Genetic Transcription;global health;Hematological Disease;Heme;hemoglobin polymer;Hemolysis;Hydrophobicity;hydroxyurea;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin M;Immunologic Markers;Immunologic Stimulation;immunological status;Immunologics;Impairment;improved;In Situ;Income;Infection;Inflammasome;Inflammatory;inflammatory milieu;influenza virus vaccine;Investigation;Iron;Ischemia;Life Expectancy;Ligands;lymph node biopsy;Mass Spectrum Analysis;Memory B-Lymphocyte;MF59;Microcirculation;Modality;Modeling;Molecular Profiling;Natural Immunity;neutrophil;Organ;Pain;Pathway interactions;patient population;Patients;Pattern recognition receptor;Peripheral Blood Mononuclear Cell;Phenotype;Point Mutation;Polyvalent pneumococcal vaccine;Predisposition;Production;protein biomarkers;Proteomics;Pulmonary Hypertension;Recurrence;responders and non-responders;response;Retinal Diseases;seroconversion;Serotyping;Serum Proteins;Severity of illness;Shapes;Sickle Cell;Sickle Cell Anemia;sickling;single cell technology;Skin;Streptococcus pneumoniae;Stroke;System;T cell response;T-Lymphocyte Subsets;Therapeutic;TLR4 gene;transcriptomics;Transfusion;United States;Vaccination;vaccination strategy;vaccine efficacy;vaccine immunogenicity;vaccine response;Vaccines;vascular abnormality;Vulnerable Populations;Whole Blood

PROJECT_TITLE: Inflammatory dysregulation of vaccine responses in sickle cell disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Hematology;Human Genome;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Sickle Cell Disease;Vaccine Related

PI_NAMEs: KLEINSTEIN, STEVEN H. (contact)

PROJECT_TERMS: Address;Adoption;aged;Autoimmune;B-Lymphocytes;Bioinformatics;Biological;Biometry;Biopsy;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinical;Clinical Medicine;cohort;Collaborations;Collection;Communicable Diseases;Communities;Complex;complex data;computerized data processing;Consultations;Data;Data Analyses;data integration;data management;Data Management Resources;data modeling;data repository;Data Security;Data Set;data sharing;data standards;Data Storage and Retrieval;data submission;Databases;Deposition;Development;Disease Outcome;draining lymph node;Ensure;Environment;Experimental Designs;experimental study;FAIR principles;frailty;Gene Expression;Gene Expression Profile;Goals;Health;Heterogeneity;heterogenous data;Human;Human Resources;Immune;Immune response;Immune system;Immunologics;Immunophenotyping;improved;In Situ;Individual;Knowledge;large datasets;Left;Linear Models;Manuscripts;Measurable;Methods;Modeling;Molecular;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;Non-linear Models;Outcome;outcome prediction;Pathway Analysis;patient population;Patients;Pattern;Population;Population Heterogeneity;power analysis;Preparation;Process;Proteomics;Public Health;rational design;Recommendation;Regimen;Reporting;repository;Research;Research Design;Research Personnel;Resources;response;Risk Factors;Sample Size;Sampling;Secure;Sequence Read Archive;Services;Sickle Cell Anemia;single-cell RNA sequencing;Skin;Software Tools;spatiotemporal;Statistical Data Interpretation;success;supervised learning;System;T-cell receptor repertoire;Testing;Time;timeline;Tissues;Training;transcriptomics;Vaccination;vaccination outcome;vaccination strategy;vaccine response;vaccine strategy;Vaccines;Validation;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Data management and analysis


NIH_SPENDING_CATS: Genetics;Infertility

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative/Relevance Defects in chromosome segregation can give rise to cells with an incorrect number of chromosomes, also known as aneuploidy. Aneuploid cells are associated with cancer, birth defects, miscarriages and infertility. Thus, understanding how cells avoid defects in chromosome segregation can help prevent, develop diagnostics for and treat these disorders.

PI_NAMEs: BHALLA, NEEDHI  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Aneuploid Cells;Aneuploidy;Behavior;Biological;Caenorhabditis elegans;Cell Cycle;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Physiology;cell type;Cells;Chromosome Segregation;Chromosome Structures;Chromosomes;Congenital Abnormality;daughter cell;Defect;Diagnostic;Disease;Future;Infertility;Malignant Neoplasms;Monitor;Organism;Play;prevent;Proteins;Regulation;response;Role;Shapes;Spontaneous abortion;Tissues;Work

PROJECT_TITLE: Cell cycle checkpoint control in C. elegans


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Violence Research

PHR: PROJECT NARRATIVE Decreasing suicide death is now a primary focus of NIMH efforts. Aggregated data across multiple large genetic studies yield heritability estimates of approximately 45%, yet research has been limited by a lack of molecular genetic data on suicide death. This project will leverage genome-wide and comprehensive health record data on suicide death to discover genetic risk factors, model genetic and clinical heterogeneity, and extend clinically relevant findings to independent cohorts.

PI_NAMEs: DOCHERTY, ANNA R. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Admixture;Age;alcohol use disorder;Attention deficit hyperactivity disorder;autism spectrum disorder;biobank;Cessation of life;Clinical;clinical heterogeneity;clinical phenotype;clinically actionable;clinically relevant;cohort;comorbidity;Complex;Computerized Medical Record;Craniocerebral Trauma;Data;Data Aggregation;Databases;Development;Diagnosis;Diagnostic;DNA;Environmental Exposure;Etiology;Feeling suicidal;follow-up;Funding;Genetic;genetic analysis;Genetic Enhancement;Genetic Heterogeneity;Genetic Models;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genotype;health record;Heritability;ideation;improved;Individual;Link;Manic;Medical;Medical Examiners;Medical Records;Metabolic;Modeling;Molecular Genetics;Mood Disorders;National Institute of Mental Health;Nature;novel;Observational epidemiology;opioid use;Pain;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Population;population based;Population Database;predictive modeling;Predictive Value;Pregnancy;Prevalence;psychiatric comorbidity;psychiatric genomics;Psychiatry;Psychopathology;Psychoses;Public Health;Research;Resources;Risk;Risk Factors;risk prediction;Sampling;Schizophrenia;sex;Sex Differences;Signal Transduction;Site;statistics;Subgroup;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Testing;United States;Utah;Variant;Work

PROJECT_TITLE: Genome-Wide Association Analysis of Suicide Death

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE The objective of this project is to determine the effectiveness of transcarotid artery revascularization (TCAR) to prevent stroke in patients with carotid artery stenosis compared to carotid endarterectomy or transfemoral carotid artery stenting. With no randomized trial of TCAR to guide treatment decisions, this study will resolve important knowledge gaps surrounding how TCAR should be used in clinical practice. In addition, this work will serve as a project-based learning example allowing Dr. Columbo to fill critical conceptual knowledge gaps in his training as a comparative-effectiveness researcher, launching his career as an independent investigator.

PI_NAMEs: COLUMBO, JESSE A (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Accounting;Area;arm;Arteries;Award;Blood Platelets;Blood Vessels;career;Caring;Carotid Arteries;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Cessation of life;Characteristics;Cholesterol;clinical application;clinical practice;Clinical Trials;cohort;comorbidity;comparative effectiveness;Comparative Effectiveness Research;comparative trial;Complement;Data;Data Collection;Data Set;Decision Making;Derivation procedure;Development;Disease;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Event;Excision;femoral artery;Femur;follow-up;Foundations;Future;Goals;Grant;high risk;Implant;Individual;Ischemic Stroke;Knowledge;Link;Longterm Follow-up;Machine Learning;Medical;Medicare claim;Medicine;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;mortality risk;Observational Study;Operative Surgical Procedures;Outcome;Patient Care;patient stratification;patient subsets;Patients;Pharmaceutical Preparations;Play;post stroke;Procedures;project-based learning;Prospective Studies;Publishing;random forest;randomized trial;randomized, clinical trials;Recommendation;Registries;Research;Research Personnel;responsible research conduct;revascularization;Risk;Risk Factors;risk stratification;Role;Safety;skills;Stroke;Stroke prevention;stroke risk;stroke therapy;Subgroup;Techniques;Technology;Testing;Training;treatment effect;treatment planning;United States;United States National Institutes of Health;Validation;Work;Writing

PROJECT_TITLE: Comparative-Effectiveness of Procedures for Carotid Revascularization

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Specific errors, also referred to as mutations, in the genetic code of normal cells turns them into cancer. However, studying how these mutations cause a normal cell to become a cancer cell remains difficult. We have developed a new approach that enables one to study thousands of cancer mutations in a single experiment.

PI_NAMEs: JI, HANLEE P (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Alternative Splicing;Amino Acid Substitution;base;base editing;base editor;Base Sequence;Biological;Biological Sciences;cancer cell;Cancer Gene Mutation;Cancer Model;cancer type;Categories;Cell Line;Cell model;Cells;Cellular Assay;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Colorectal Cancer;Complementary DNA;CRISPR/Cas technology;Data;data integration;Data Set;design;Detection;DNA;Engineering;Exons;Experimental Models;experimental study;Gene Expression;Gene Expression Profile;gene function;Gene Targeting;Genes;Genetic;Genetic Code;Genetic Transcription;genome editing;genomic platform;Genomics;Genotype;Guide RNA;in silico;Individual;Introns;Length;Link;Malignant Neoplasms;malignant stomach neoplasm;Messenger RNA;Methods;Modeling;mRNA sequencing;Mutation;mutation screening;nanopore;Normal Cell;novel;novel strategies;nuclease;Oncogenes;Organoids;parallelization;Pattern;Point Mutation;Process;Protein Isoforms;Reporting;Resolution;RNA Sequences;RNA Splicing;screening;single cell genomics;single cell sequencing;single molecule;single-cell RNA sequencing;Somatic Mutation;technological innovation;Technology;Testing;tissue culture;tool;Transcript;transcriptome

PROJECT_TITLE: Single cell modeling of cancer mutations


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Rare Diseases;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Hospitalizations for serious injection-related infections may motivate individuals to seek treatment with medications for opioid use disorder which reduce mortality and re-hospitalization in this population. However, the benefits of medications for opioid use disorder are not fully realized for individuals with serious injection- related infections due to limited treatment retention. This Career Development Award will use insights from public health treatment data and qualitative interviews to systematically adapt and evaluate a medication for opioid use disorder retention intervention, Recovery Management Checkups, for individuals with serious injection-related infections. Simeon Kimmel, MD, MA

PI_NAMEs: KIMMEL, SIMEON  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;acute care;Acute suppurative arthritis due to bacteria;addiction;Address;Advisory Committees;Antibiotics;Area;Bacteremia;Biometry;Board Certification;Boston;Buprenorphine;career;Caring;Cessation of life;checkup examination;Clinical Trials;Clinical Trials Design;Communicable Diseases;Complex;Continuity of Patient Care;cost;Data;Data Set;Death Rate;design;Development;Drug usage;effectiveness trial;Endocarditis;Enrollment;Epidural Abscess;Event;evidence base;Evidence based intervention;experience;Future;Goals;Health care facility;Healthcare Systems;high risk population;Home;hospital care;hospital readmission;Hospitalization;Hospitals;Imprisonment;improved;Individual;Infection;Infective endocarditis;Injectable;Injections;Inpatients;insight;Intervention;Interview;Intravenous;K-Series Research Career Programs;large datasets;Lead;Link;Massachusetts;Medical;Medical center;medication for opioid use disorder;Medicine;Mentorship;Methadone;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;Naltrexone;National Institute of Drug Abuse;novel;opioid epidemic;opioid injection;opioid overdose;opioid use;opioid use disorder;Osteomyelitis;Outcome;Outpatients;outreach;Overdose;Participant;peer;Persons;Population;Positioning Attribute;prevent;Primary Care;programs;Public Health;Qualitative Methods;randomized trial;Randomized, Controlled Trials;Records;Recovery;Recurrence;Research;Research Personnel;response;skills;Specialist;Structure;substance use treatment;success;Testing;therapy development;Training;trial design;Work

PROJECT_TITLE: Retention and Re-Engagement in Treatment for Addiction following Serious Injection Related Infections (RETAIN)


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project narrative The proposed research is relevant to public health because the success of the proposal could help us in the future to design disease modifying drugs to prevent, reverse, or slow down the progression of cardiac fibrosis that could lead to eventual heart failure.

PI_NAMEs: LIU, ZHI-PING  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adult;Affect;angiogenesis;autocrine;Binding;Biological Assay;Blood;Blood Vessels;Bone Development;Cardiac;Cartilage;cartilage development;CD36 gene;cell behavior;Cell Communication;Cell Proliferation;Cell Proliferation Regulation;cell type;Cicatrix;Clinical;Collagen;Conditioned Culture Media;coronary fibrosis;Cues;cytokine;Deposition;design;Development;differential expression;Disease;DNA cassette;effective therapy;Electric Conductivity;Embryonic Development;Enterobacteria phage P1 Cre recombinase;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;genomic locus;Growth Factor;Heart;heart cell;Heart Diseases;Heart failure;heart function;heart preservation;inducible Cre;Infarction;Inflammation;Inflammatory;Injury;insight;Integrins;Interleukin-6;ischemic injury;Knock-out;Knockout Mice;Left Ventricular Hypertrophy;Liver Fibrosis;Macrophage;Measures;Molecular;Molecular Profiling;Mus;Mutagenesis;Myocardial Infarction;Myocardium;Myofibroblast;N-terminal;Necrosis;NFKB Signaling Pathway;organ growth;Outcome;overexpression;paracrine;Pathologic;Pathway interactions;periostin;Pharmaceutical Preparations;Phenotype;Physiological;postnatal;prevent;Process;Production;Proliferating;promoter;Property;Protein Secretion;Proteins;Proteomics;Public Health;Reagent;receptor;Receptor Cell;receptor-mediated signaling;Recombinants;Regenerative capacity;Research;response to injury;Risk Factors;Role;Shapes;Signal Pathway;single nucleus RNA-sequencing;Structural Protein;success;Tamoxifen;tendon development;Testing;Therapeutic;therapeutic target;Tissues;Transgenic Mice

PROJECT_TITLE: Role of Cilp1 in Post-Natal Heart Response to Injury

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Opioid drugs remain the most effective analgesics for the treatment of moderate and severe pain. However, chronic opioid use can cause pain hypersensitivity and the loss of their analgesic effects, which remain a major obstacle for adequate treatment of painful conditions using opioid drugs. This proposed work will identify the key molecular targets responsible for opioid-induced pain hypersensitivity and tolerance and provide new information for the design of effective strategies to improve pain treatment with opioid drugs.

PI_NAMEs: CHEN, SHAO-RUI ;PAN, HUI-LIN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;addiction;Afferent Neurons;Agonist;Analgesics;Attenuated;Behavioral;BRAF gene;Chronic;Clinical;Complex;Cultured Cells;Dependence;design;Development;dorsal horn;Dose;Electrophysiology (science);excitatory neuron;Extracellular Signal Regulated Kinases;FDA approved;Fentanyl;Glutamates;Hyperactivity;Hyperalgesia;Hypersensitivity;Impairment;improved;In Vitro;in vivo;inhibitor;interdisciplinary approach;knock-down;Knock-in;knockout gene;Link;Malignant Neoplasms;Mediating;MEKs;Metabotropic Glutamate Receptors;Molecular;Molecular Target;Morphine;mu opioid receptors;N-Methyl-D-Aspartate Receptors;Neurons;Nociception;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid use;overdose death;Pain;Pain management;pain relief;Patients;Pharmaceutical Preparations;Phosphorylation;Pilot Projects;Play;Posterior Horn Cells;preservation;presynaptic;Protein Biochemistry;Protein Kinase;Role;Serine;Signal Pathway;Signal Transduction;Slice;Spinal;Spinal Cord;Spinal Ganglia;Synapses;synaptic inhibition;Testing;Threonine;trafficking;transmission process;Trauma;Work

PROJECT_TITLE: Signaling Mechanisms of Opioid-Induced Hyperalgesia and Tolerance

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: There is a growing emphasis on and the need to utilize advances in the fields of omics, big data, and systems science to understand how the interactions between individual, micro-, meso- and macrosystems influence health and disease. We need to train nurse scientists who can utilize the skills necessary to incorporate systems science approaches to health promotion across the lifespan. With this preparation, new and innovative approaches to enhance health at the individual and population levels can be developed and tested.

PI_NAMEs: DOUGHERTY, CYNTHIA M (contact);HEITKEMPER, MARGARET MCLEAN

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TITLE: Interdisciplinary Nurse Scientist Training in Multilevel Approaches: Biology to Society


ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Public Health Relevance Statement The InQuBATE T32 at the Georgia Institute of Technology will train PhD candidates spanning the biosciences, engineering, and computing to integrate computational models, data analytics, and the experimental study of molecules, cells, and populations. By fostering a quantitative and data-driven mindset, the T32 will train the next generation of thought leaders to identify principles underlying transitions between health and disease in complex living systems spanning microbial communities, developmental pathways, tumor microenvironments and the dynamics of tissue. Overall, InQuBATE will help transform the foundational and applied study of computational- and data-intensive biosciences in the 21st century and prepare diverse trainees for impactful careers across academia and industry.

PI_NAMEs: GUMBART, JAMES C.;QIU, PENG  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Integrative and Quantitative Biosciences Accelerated Training Environment


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Pathogenic variants in the gene KCNC1 encoding the voltage-gated potassium channel subunit KV3.1 have recently been established as a cause of neurological disease, yet the cellular, synaptic and circuit mechanisms underlying cognitive impairment and epilepsy in KCNC1-related disorders is unknown. Using a novel mouse model of KCNC1-related epileptic encephalopathy, I propose to link across scales to define the ion channel, neuronal, synaptic and circuit-basis of this devastating disorder, as well as basic roles of KV3 channels in normal physiology. This training fellowship will capitalize on my experimental strengths while addressing key gaps in my conceptual knowledge and technical skills and methodology to propel me toward my career goal to be an independent investigator committed to understanding the mechanistic basis of neurological diseases to inform novel treatment development.

PI_NAMEs: WENGERT, ERIC RYAN (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Action Potentials;Address;Ataxia;awake;Axon;barrel cortex;Behavior;Behavioral;biophysical properties;Calcium;calcium indicator;career;Cells;Cerebral cortex;Characteristics;Complex;Dendrites;density;Disease;Disinhibition;early onset;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Event;excitatory neuron;Exhibits;experimental study;Fellowship;Frequencies;Functional disorder;Generations;Genes;Goals;Heterozygote;hippocampal pyramidal neuron;Image;Impaired cognition;Impairment;In Vitro;in vivo;Individual;insight;Intellectual functioning disability;Interneuron function;Interneurons;Ion Channel;Knowledge;Link;loss of function;Measures;Mediating;Mentors;Methodology;mouse model;Mus;mutant;National Research Service Awards;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neurologic;neuronal cell body;neuronal circuitry;neuronal excitability;Neurons;Neurosciences;neurotransmission;novel;Optics;Other Genetics;Parvalbumins;patch clamp;Pathogenesis;Pathogenicity;Patients;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Potassium;Potassium Channel;Presynaptic Terminals;Productivity;Progressive Myoclonic Epilepsies;Property;Recovery;Recurrence;Research;Research Personnel;response;Role;Seizures;Sensory;Sodium Channel;Symptoms;Synapses;synaptic inhibition;Synaptic Transmission;Technical Expertise;Techniques;Testing;therapy development;Training;two-photon;Variant;Vibrissae;voltage;Voltage-Gated Potassium Channel;Wild Type Mouse

PROJECT_TITLE: Mechanisms of cellular, synaptic and circuit dysfunction in Kcnc1-related epileptic encephalopathy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Kidney Disease

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE: Left ventricular assist devices (LVADs) are increasingly used in the US to support heart function in the growing population with advanced heart failure, and they can improve length and quality of life. However, worsening or persistent kidney dysfunction after LVAD placement is common and harmful. This project seeks to understand and predict how LVADs affect kidney health, to help patients who receive LVADs achieve longer, healthier lives.

PI_NAMEs: WALTHER, CARL  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;advanced analytics;Affect;analytical method;Anatomy;Animal Model;Animals;Area;Bayesian Analysis;Biological;Biological Markers;biomarker panel;blood pressure control;Board Certification;Cardiac Output;Cardiac Surgery procedures;Cardiorenal syndrome;cardiovascular health;career;Central venous pressure;Cessation of life;Characteristics;Chronic;Clinical;Clinical Data;Clinical Investigator;Clinical Research;Cluster Analysis;Coca;cohort;college;Complex;Congestive Heart Failure;Creatinine;Databases;Dialysis procedure;Dimensions;Disease;Doctor of Philosophy;Environment;Event;experience;Factor Analysis;Fibrosis;Filtration;Foundations;Functional disorder;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Transplantation;high risk;Hour;implantation;improved;Individual;Inflammation;inflammatory marker;Injury;innovation;insight;interstitial;Ischemia;Kidney;Kidney Diseases;kidney dysfunction;kidney imaging;Kidney Transplantation;Knowledge;left ventricular assist device;Length;Master of Science;Measurement;Measures;mechanical circulatory support;Medical center;medical specialties;Medicine;Mentors;Modernization;Multicenter Trials;multidimensional data;Nephrology;Niacinamide;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Outcome;Patients;Perioperative;Persons;Phenotype;Physiology;Population;precision medicine;predictive modeling;Process;professor;prospective;Quality of life;randomized trial;Refractory;renal damage;Renal function;repaired;Research;Research Methodology;Research Support;Research Technics;Risk;Risk Assessment;Science;Sepsis;Serum;Severities;symposium;systemic inflammatory response;Techniques;Texas;Time;Training;Training Programs;Tubular formation;Uncertainty;Variant

PROJECT_TITLE: The kidney in advanced heart failure and durable mechanical circulatory support: phenotypes, prediction, and pathophysiology


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: PISCATAWAY

ORG_DEPT: NUTRITION

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  The phosphatidate phosphatase is a conserved enzyme from yeast to human that catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol that is used for the synthesis of triacylglycerol and the major phospholipids phosphatidylcholine and phosphatidylethanolamine. The enzyme-mediated control of phosphatidate content plays a key role in the transcriptional regulation of phospholipid synthesis genes, membrane phospholipids, and growth of the nuclear/endoplasmic reticulum membrane. Genetic defects in yeast, mouse, and human are manifested in metabolic disorders that include obesity, lipodystrophy, peripheral neuropathy, myoglobinuria, and inflammation.

PI_NAMEs: CARMAN, GEORGE M. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biochemistry;Cell Physiology;chronic recurrent multifocal osteomyelitis;Complex;Congenital dyserythropoietic anemia;Cytosol;Defect;derepression;Diglycerides;Disease;Endoplasmic Reticulum;Enzymes;Fatty Liver;Gene Expression;gene synthesis;Genes;Genetic Variation;Growth;Homeostasis;Human;Inflammation;Insulin Resistance;Lecithin;lipid biosynthesis;lipid metabolism;Lipids;lipine;Lipodystrophy;Location;Mediating;Membrane;Membrane Proteins;Metabolic Diseases;Molecular Genetics;Mus;Mutation;Myoglobinuria;Nature;neonatal period;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Obesity;overexpression;Peripheral;Peripheral Nervous System Diseases;phosphatidate;Phosphatidate Phosphatase;Phosphatidylethanolamine;Phospholipids;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Process;Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Regulation;Rhabdomyolysis;Role;Structure;trafficking;Transcriptional Regulation;Triglycerides;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]