NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Calcium entry via voltage-gated calcium channels controls many aspects of neuronal function, and precise coupling of calcium signals to effector mechanisms maintains homeostasis. The alpha2delta family of voltage- gated calcium channel subunits is required for normal brain function, however the cellular mechanisms underlying the functional roles of these proteins in neurons remain poorly defined. This proposal will investigate the role of these subunits in mediating the functional coupling of calcium entry to effector mechanisms across the brain, and help define a central role of this protein family in controlling neuronal signaling.

PI_NAMEs: SCHNELL, ERIC  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acceleration;Action Potentials;Acute;Ataxia;autism spectrum disorder;Binding;Binding Proteins;Biological Assay;Brain;brain control;Buffers;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;cell type;Cells;CNR1 gene;Compensation;Complex;Coupled;Coupling;Data;deafness;Development;Diffuse;Disease;Disparate;Drug Modulation;Drug Targeting;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Epilepsy;experimental study;Family;Fiber;gabapentin;Gene Modified;Genes;Hippocampus;Homeostasis;Human;improved;Individual;Inhibitory Synapse;insight;Knockout Mice;Link;loss of function;Mediating;Mediator;Membrane;Migraine;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;nano;Nervous System Disorder;Neurologic;neuronal excitability;Neurons;neuropathology;neurotransmission;novel;Pharmaceutical Preparations;Phenotype;Play;postsynaptic;postsynaptic neurons;Potassium Channel;presynaptic;Presynaptic Terminals;prevent;Process;Property;Protein Family;protein function;Protein Isoforms;Protein Subunits;Proteins;Publishing;Purkinje Cells;receptor;Role;Runaway;Signal Transduction;Slice;Source;Surface;Synapses;synaptic function;Synaptic plasticity;Testing;trafficking;vesicular release;Virus;voltage;voltage clamp;Whole-Cell Recordings

PROJECT_TITLE: Alpha2delta-mediated control of neuronal signaling

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative This prospective epidemiologic study is identifying novel factors, including plasma proteins, that contribute to increased risk of venous thromboembolism, i.e., blood clots in veins that may travel and block the blood supply to organs. This information will have important implications for the prevention and treatment of this common and significant cardiovascular disease.

PI_NAMEs: TANG, WEIHONG  (contact)

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Address;African American;aptamer;Atherosclerosis Risk in Communities;Biological Assay;Biological Process;Black Populations;Blood coagulation;Cardiovascular Diseases;cardiovascular health;cohort;Cohort Studies;common treatment;Community Health;Data;Deep Vein Thrombosis;Epidemiology;epidemiology study;Etiology;Event;Exclusion;follow-up;Future;Genetic;genetic association;genetic variant;Genetic Variation;genome wide association study;Genomics;Hemostatic Agents;Human;improved;Incidence;Individual;Individual Differences;Inflammatory;Intervention;Investigation;Knowledge;liquid chromatography mass spectrometry;Measures;Mediator;Mendelian randomization;Methods;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;non-genetic;Norway;novel;Organ;Participant;Pathogenesis;Pathway Analysis;Pathway interactions;Plasma;Plasma Proteins;population based;Populations at Risk;Prevention;Productivity;prospective;Prospective Studies;protein biomarkers;Proteins;Proteomics;Publications;Pulmonary Embolism;Reporting;Research Priority;Resources;Risk;Risk Factors;Risk Marker;Sampling;Scanning;Thromboembolism;Travel;Vascular blood supply;Veins;venous thromboembolism;Venous Thrombosis;Visit

PROJECT_TITLE: Epidemiology of Venous Thrombosis and Pulmonary Embolism

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE One major goal in human health is to understand the complex processes that permit regeneration of whole organs. A common approach is to employ a simplified model to address complex problems like regeneration. The proposal uses plants, which are highly adept at regeneration, as a tractable model to decode the signals that lead to complete organ repair.

PI_NAMEs: BIRNBAUM, KENNETH DAVID (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Adult;adult stem cell;Amino Acids;Body part;Cell Communication;Cell Reprogramming;cell type;Cells;Chemistry;Communication;Complex;design;Development;Distant;Embryo;Excision;Fibrinogen;Goals;Health;Human;Imaging Techniques;Injury;Label;Mass Spectrum Analysis;Mediating;Medical;Methods;Modeling;Movement;National Institute of General Medical Sciences;Natural regeneration;new technology;novel strategies;Organ;Organ Model;organ regeneration;organ repair;Organogenesis;Plants;Postembryonic;Process;programs;Proteins;reconstruction;repair model;Research;Role;self organization;Signal Transduction;single-cell RNA sequencing;stem cell niche;System;Techniques;Testing;Tissues;tool;transcription factor;transcriptomics;Work

PROJECT_TITLE: A model of repair: intercellular signaling and self-organization in plant regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative In this proposed study, we will investigate the mechanistic roles of gain-of-function p53 mutations in promoting metastasis and immunosuppression through the activation of non-canonical NF-κB signaling. We will further explore therapeutic strategies for the treatment of head and neck cancers with gain-of-function p53 mutations.

PI_NAMEs: MYERS, JEFFREY NICHOLAS (contact);SIKORA, ANDREW

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Alkylating Agents;B-Cell Activation;cancer cell;carcinogenesis;Cells;chemokine;Chromosomal Instability;Complex;Cyclic GMP;cytokine;cytotoxicity;Data;design;Development;Disease;DNA;DNA biosynthesis;effective therapy;Enhancers;gain of function;Genes;Genomic Instability;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;IL8 gene;Immunosuppression;In Vitro;in vivo;Incidence;Inflammation;innovation;Interferons;Interleukin-6;Invaded;Knowledge;Licensing Factor;Light;Link;Maintenance;Malignant Neoplasms;MCM5 gene;Mediating;mutant;Mutate;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;novel therapeutic intervention;Nuclear;Patients;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Production;Proliferating;Proteomics;Public Health;Replication Licensing;replication stress;Reporting;Research;Resistance;response;Role;Signal Transduction;Stimulator of Interferon Genes;targeted treatment;temozolomide;Testing;Therapeutic;TP53 gene;treatment strategy;tumor;Tumor Cell Invasion;Tumor Immunity;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Functional roles of GOF TP53 mutations in metastasis and immunosuppression of head and neck cancers

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative The matrisome consists of glycosylated extracellular matrix and cell surface proteins that surround cells and support normal physiological activity. While it is known that glycosylation changes during disease processes, it has not been possible to quantitatively compare glycoprotein structure among biological samples. We aim to develop technologies to meet this need.

PI_NAMEs: ZAIA, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Age;Aging;analytical method;Animals;antibody detection;Award;Binding;Bioinformatics;Biological;Brain;Brain region;Cell Surface Proteins;Cells;Clinical Trials;Cytoplasmic Granules;Data;Detection;detection method;Disease;Extracellular Matrix;Focus Groups;Funding;glycoprotein structure;Glycoproteins;glycoproteomics;Glycosaminoglycans;glycosylation;Goals;instrument;ion mobility;liquid chromatography mass spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Methods;Molecular;National Institute of General Medical Sciences;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;normal aging;pathogen;Peptides;Periodicity;Physiological;Physiology;Polysaccharides;Process;programs;Proteins;Proteoglycan;Proteomics;Research;Research Personnel;Sampling;Serine;Signal Transduction;Slide;Sulfate;Surface;Technology;Tissues;Water

PROJECT_TITLE: Methods for measuring matrisome molecule similarity during disease processes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation (transcranial alternating current stimulation (tACS)) and a novel form of closed-loop digital meditation (MediTrain).

PI_NAMEs: ZANTO, THEODORE P;ZIEGLER, DAVID A (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: Acceleration;Adult;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;attentional control;Blood;Cephalic;Clinical Markers;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive enhancement;Cognitive remediation;cognitive reserve;cognitive task;Combined Modality Therapy;Coupling;Data;Dementia;dementia risk;digital;efficacy evaluation;examination questions;Exhibits;Forehead;Foundations;Frequencies;functional decline;Future;Goals;group intervention;high risk;Home;Impaired cognition;improved;improvement on sleep;indexing;Intervention;Length;Meditation;mild cognitive impairment;Monitor;neural stimulation;neuropathology;noninvasive brain stimulation;normal aging;novel;older adult;Outcome Measure;Participant;Patients;Performance;Personal Satisfaction;Physiological;Pilot Projects;Placebos;Population;pre-clinical;Prefrontal Cortex;prevent;Randomized, Controlled Trials;Reaction Time;Regulation;remediation;Research;Risk;Sleep;Stress;stress reactivity;stress reduction;Subgroup;sustained attention;telomere;Testing;Therapeutic;Time;tool;Training;wearable sensor technology;young adult

PROJECT_TITLE: Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Inflammation is a double-edged sword, with the ability to rid the body of invading microorganisms and to cause collateral tissue damage when these mechanisms are out of balance. Oral bacteria such as Porphyromonas gingivalis, one of the main causative agents in the progression of periodontal disease, employ different strategies of subverting or enhancing the immune response to facilitate their own survival. Elucidating these methods of survival will ultimately lead to novel therapeutic targets to prevent bacteria-induced inflammation and to treat periodontitis.

PI_NAMEs: LOHNER, HANNAH  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Affect;alveolar bone;Alveolar Bone Loss;Area;Attenuated;Award;Bacteria;Bacterial Infections;Binding;bone loss;Bone Resorption;career;Cell Nucleus;Cells;Chronic;chronic inflammatory disease;CXCL2 gene;cytokine;Cytoplasm;Data;Deacetylation;Disease;Disease Progression;Economics;Elements;Enzymes;Equilibrium;experience;experimental study;Fellowship;FOXO1A gene;Fusobacterium nucleatum;gain of function;Genes;Genetic Transcription;Gingiva;Goals;HDAC6 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;Immune;Immune response;Immunology;improved;in vivo;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-12;Interleukin-6;Invaded;Knockout Mice;loss of function;Macrophage;Measures;Mediating;member;Methods;Microbe;Microbiology;microorganism;migration;model organism;Modeling;Molecular;Molecular Biology;Mus;neutrophil;Neutrophil Infiltration;new therapeutic target;non-histone protein;novel;novel therapeutic intervention;Nuclear Translocation;Oral;oral bacteria;oral infection;Osteitis;pathogen;pathogenic bacteria;Patients;Pattern;Periodontal Diseases;Periodontal Ligament;Periodontitis;Periodontium;Phosphorylation;Play;Population;Porphyromonas gingivalis;prevent;Process;Production;promoter;Protein Acetylation;Proteomics;Quality of life;Reaction;Regulation;Reporting;Research;response;Rheumatoid Arthritis;Role;Severities;Signal Pathway;Signal Transduction;subcutaneous;Testing;therapeutic target;Tissues;TNF gene;Tooth Loss;Training;transcription factor;transcriptomics;United States;Virus;Work

PROJECT_TITLE: The Role of Histone Deacetylase 6 in Oral Bacteria-Mediated Periodontal Inflammation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Amyotrophic Lateral Sclerosis (ALS);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Several neurodegenerative diseases are associated with the formation specific protein aggregates that form as a result of protein misfolding. We will use a yeast model to study such proteins, focusing on TDP-43 because its aggregates are associated with many neurodegenerative diseases. As yeast models have successfully identified human misfolding disease risk factors, it is likely that insights gained here about aggregate genesis, causes of toxicity and methods to rescue from toxicity will be applicable to human disease.

PI_NAMEs: LIEBMAN, SUSAN W (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Amyloid;Amyotrophic Lateral Sclerosis;Area;Binding Proteins;Cell Physiology;Cells;cellular targeting;Characteristics;Cytoplasmic Granules;Dementia;Development;Disease;disorder risk;Frontotemporal Dementia;gain of function;Gene Modified;Growth;Human;human disease;insight;Learning;Liquid substance;Methods;Modeling;Mutation;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;Organism;overexpression;Parkinson Disease;Physical condensation;prion seeds;prion-like;Prions;protein aggregation;protein misfolding;protein TDP-43;Proteins;PrP;Risk Factors;Therapeutic;therapeutic target;Titrations;tool;Toxic effect;Variant;Work;Yeast Model System;yeast prion;Yeasts

PROJECT_TITLE: Yeast as a gateway to conquering protein misfolding diseases.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Neuronal activity triggers the expression of new genes that play a critical role in aspects of neural development and cognitive function. The proposed study investigates how this regulatory mechanism contributes to experience-dependent neural plasticity in the central nervous system.

PI_NAMEs: GREENBERG, MICHAEL ELDON (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Address;Anxiety;Apical;Architecture;autism spectrum disorder;Axon;behavioral response;Brain;Brain-Derived Neurotrophic Factor;cell type;Cells;Central Nervous System;Cholecystokinin;Chromatin;chromogranin C;Cognition Disorders;cognitive function;Complex;Defect;Dendrites;Development;Disease;Electric Stimulation;Epilepsy;Etiology;experience;Extinction;Feedback;Fright;gain of function;Gene Expression;Gene Expression Regulation;gene product;Genes;Genetic Transcription;Hippocampus;Human;Immediate-Early Genes;in vivo;insight;Interneurons;Investigation;Knockout Mice;Laboratories;Learning;loss of function;Mediating;Mediator;memory process;Methods;motor learning;Mus;Myoepithelial cell;neocortical;Nervous System Disorder;neurodevelopment;neuronal cell body;Neuronal Plasticity;Neurons;Neuropeptides;neuropsychiatry;novel;novel therapeutic intervention;NPAS4 gene;Parvalbumins;Physiological;Play;Population;Positioning Attribute;Post-Translational Protein Processing;postsynaptic;Process;programs;Pyramidal Cells;receptor;Regulation;response;Role;Schizophrenia;Sensory;Signal Pathway;single-cell RNA sequencing;spatial memory;Specific qualifier value;Stereotyping;Stimulus;Stress;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;trafficking;transcription factor;Transcriptional Activation;Transcriptional Regulation;Translations;Vertebral column

PROJECT_TITLE: Electrical Stimulation of Immediate Early Genes

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: GENETICS

ORG_STATE: OR

PHR: PROJECT NARRATIVE: Current treatments for FTD mitigate some behavioral changes, but there are no therapies that prevent or slow the progression of the disease. Profiling the epigenetic changes in FTD disease-associated Tau expressing Drosophila will help to elucidate the nuclear mechanisms of mutant Tau and yield insight into FTD disease progression. This work will also lead to the identification of novel targets for potential treatment development.

PI_NAMEs: LOWENSTEIN, EVE  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Actins;Address;Adult;Affect;Age;age related;age related changes;aged;Aging;Apoptosis;Architecture;Atlases;Atrophic;Autopsy;Axon;axon growth;behavior change;Behavioral;behavioral phenotyping;Binding Proteins;Biological Models;Brain;Candidate Disease Gene;Cell Death;Cell Nucleus;cell type;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Structure;Chromium;Clinical;Code;Computer Analysis;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Dementia;Detection;Development;Disease;Disease Progression;Drosophila genus;Drosophila melanogaster;Enhancers;Epigenetic Process;epigenetic profiling;Exhibits;experimental analysis;experimental study;fly;FMNL2 gene;Frontotemporal Dementia;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic manipulation;Genomics;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Histologic;Histones;Human;imaging study;in vivo Model;insight;knock-down;Knock-in;Life Expectancy;life span;Link;Locomotion;longitudinal analysis;Longitudinal Studies;Lysine;Maps;Memory;Memory impairment;Methylation;Microtubules;model organism;Modeling;Modification;Molecular;Molecular Probes;Morphologic artifacts;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurons;normal aging;novel;Nuclear;Nuclear Lamina;older adult;overexpression;Parkinsonian Disorders;Pathogenicity;Pathology;Patients;Personality;Phenotype;prevent;promoter;Proteins;Relaxation;Resolution;Role;Sampling;single cell technology;single-cell RNA sequencing;System;targeted treatment;tau mutation;tau Proteins;Tauopathies;Temporal Lobe;Testing;therapy development;Tissues;Toxic effect;Vacuole;Work

PROJECT_TITLE: Effects of frontotemporal dementia-associated Tau mutations on nuclear organization in a Drosophila melanogaster human tauopathy model


NIH_SPENDING_CATS: Aging;Osteoporosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_DEPT: ORTHOPEDICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Aged-related bone loss, as seen in diseases such as osteoporosis, is a major global health problem that is characterized by a decline in skeletal stem and progenitor cell (SSPC) number and function. Therefore, it is imperative to maintain a sufficient pool of SSPCs for differentiation into osteoblasts for healthy bone homeostasis and bone regeneration during injury during aging. I hypothesize that Notch signaling is essential in maintenance of the skeletogenic stem cell pool during adulthood and aging through the induction of Ebf3 expression in SSPCs.

PI_NAMEs: REMARK, LINDSEY HOPE (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adult;Affect;Age;age related;age related decline;Age-Related Bone Loss;Aging;aging population;American;Animals;Biological Assay;Biology;bone;bone fracture repair;bone fragility;bone healing;bone loss;bone mass;Bone Regeneration;Bromodeoxyuridine;cell behavior;Cell Count;Cell Cycle Progression;Cell Maintenance;Cell Proliferation;Cell surface;Cells;Chronic;combat;conditional knockout;Data;disability;Disease;Economic Burden;Elements;Exhibits;experimental study;Femur;Flow Cytometry;fracture risk;Frequencies;Genes;global health;Health;high risk;Homeostasis;Human;human old age (65+);Impairment;In Vitro;in vivo;Individual;Injury;insight;Knock-out;Knockout Mice;Label;life span;Link;Literature;Maintenance;Mediating;Mediator;middle age;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nicastrin protein;notch protein;novel;Orthopedics;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;Osteoporosis;overexpression;Patients;Persons;Phenotype;Physiologic pulse;Play;prevent;Proliferating;Publishing;Quality of life;Regenerative Medicine;Role;self-renewal;Signal Transduction;skeletal;Skeletal bone;skeletal stem cell;Skeleton;Small Interfering RNA;Stains;stem cell biology;stem cell differentiation;stem cell function;stem cell homeostasis;stem cell self renewal;stem cells;stemness;substantia spongiosa;Testing;Therapeutic;therapeutic target;tibia;Time;Training;transcriptome sequencing;Undifferentiated;Unemployment;Work

PROJECT_TITLE: Dissecting the Molecular Mechanisms that Govern Notch Mediated Skeletal Stem Cell Maintenance Throughout Adulthood/Aging.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE To identify new treatment targets, the genomics of Alzheimerʹs disease (AD) has been examined primarily in non-Hispanic White populations. We propose here a genomics study of AD in Hispanic populations with Amerindian and southern European ancestry. We will use whole-genome sequencing in these populations together with information about ancestry and ethnicity to identify genetic variation influencing AD and to generalize existing AD genetic discoveries to this underrepresented groups.

PI_NAMEs: BEECHAM, GARY WAYNE;CELIS, KATRINA ;PERICAK-VANCE, MARGARET A. (contact);RAJABLI, FARID

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Admixture;admixture mapping;African American population;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amerindian;Amyloid beta-Protein;Astrocytes;Awareness;Bioinformatics;Biological;Biological Markers;Brain;brain tissue;Caribbean region;Cell Physiology;Code;cohort;Collaborations;Collection;Cuban American;Data;Data Set;Dementia;Diagnosis;Disease;Ethnic Origin;Ethnic Population;European;European ancestry;Evaluation;Family;Family member;follow-up;Follow-Up Studies;functional genomics;Genes;Genetic;genetic architecture;Genetic Diseases;genetic linkage analysis;Genetic study;Genetic Transcription;Genetic Variation;genome editing;genome sequencing;genomic data;Genomics;Goals;Haplotypes;Health;Heterogeneity;Hispanic Populations;improved;in silico;Individual;induced pluripotent stem cell;Investigation;Literature;Maps;Measures;Methods;Mexican;Microglia;mild cognitive impairment;Native Americans;Neurocognitive;Neurons;Neuropsychology;Not Hispanic or Latino;novel;older adult;Pathway Analysis;Pathway interactions;Peruvian;Plasma;Population;Population Heterogeneity;Prevention;programs;protective factors;protein expression;Proteins;Puerto Rican;racial population;rare variant;Risk;risk prediction;risk variant;Role;Screening procedure;South American;tau expression;tau Proteins;Testing;Tissue Donations;transcriptomics;Underrepresented Populations;United States;Variant;whole genome

PROJECT_TITLE: Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Despite the prevalence and huge societal costs of Alcohol Use Disorder (AUD) – and in particular, binge drinking – few viable treatments exist, in part driven by the lack of mechanistic understanding of the disorder. This project will use advanced technologies and well-founded methods to investigate the involvement of a specific population of neurons and peptides in the prelimbic cortex in binge drinking behavior. This work will provide key insights into the neurobiological underpinnings of binge drinking, and support efforts to develop treatments for reducing AUD.

PI_NAMEs: CROWLEY, NICOLE ASHLEY (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Alcohol consumption;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;Animals;Anti-Anxiety Agents;anxiety-like behavior;anxiety-related behavior;Bathing;Behavior;Behavioral;behavioral phenotyping;Bilateral;binge drinking;brain cell;Brain Diseases;Brain region;Calcium Signaling;Cannulations;cell type;Cessation of life;Chronic;Complement;Complex;cost;Criminal Justice;Data;depressive symptoms;Disease;drinking behavior;Drug Targeting;effective therapy;Electrophysiology (science);experimental study;Fiber;Funding;Genetic;genetic manipulation;Goals;Health;Healthcare;Heavy Drinking;hippocampal pyramidal neuron;in vivo;insight;Literature;Maps;Mental disorders;Methods;Mood Disorders;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurons;Neuropeptides;neuropsychiatric disorder;new therapeutic target;Nucleus Accumbens;Octreotide;optogenetics;Output;Pathway interactions;Pattern;Peptide Signal Sequences;Peptides;Photometry;Play;Population;Prevalence;prevent;Prevention;Public Health;reduced alcohol use;Relapse;resilience;Role;sex;Signal Transduction;Site;Social Work;societal costs;Somatostatin;somatostatin analog;Somatostatin Receptor;Structure of terminal stria nuclei of preoptic region;substance misuse;System;targeted treatment;Technology;Therapeutic;therapeutic candidate;therapeutic target;timeline;transmission process;Work

PROJECT_TITLE: Prelimbic somatostatin peptide signaling in binge ethanol consumption

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE: RV-C is a major contributor to wheezing illnesses and exacerbations of asthma in young children. Vaccination to prevent RV-C infections, especially in infants with genetic polymorphism in RV-C cellular receptor CDHR3 (rs6967330), could have major public health impact. The goals of this study, that include identification of host and viral determinants of neutralizing antibody responses, determining antigenic cross-reactivity between RV-C types, and mapping major neutralizing immunogenic epitopes, could enable formulation of a broadly protective multivalent RV-C vaccine. 1

PI_NAMEs: BOCHKOV, YURY A (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 16 year old;2 year old;acquired immunity;Age;airway remodeling;Animal Model;Anti-viral Agents;Antibody Response;Appearance;Asthma;asthma exacerbation;B-Lymphocytes;Binding;Biological Assay;Birth;Bronchiolitis;Capsid;Capsid Proteins;Cell Line;Cell surface;Child;Childhood;Childhood Asthma;Chronic Obstructive Pulmonary Disease;Classification;Clinical Trials;Code;Cohort Studies;Common Cold;Common Epitope;Complex;cross reactivity;Cryoelectron Microscopy;Data;Development;early onset;Embryo;Epitopes;Family Picornaviridae;Fibroblasts;Fingers;Formulation;Genes;Genetic Polymorphism;Genotype;Goals;human monoclonal antibodies;Humoral Immunities;immunogenic;Infant;Infection;Knowledge;Life;Link;longitudinal dataset;Lower Respiratory Tract Infection;Lung;Maps;Meta-Analysis;Molecular Conformation;Monitor;monoclonal antibody production;mouse model;Mus;Natural Immunity;neutralizing antibody;novel;overexpression;Pattern;Plasma;Preschool Child;prevent;Prevention;Prevention strategy;prospective;Public Health;receptor;Recombinants;respiratory;response;Rhinovirus;Rhinovirus infection;Risk;Risk Factors;Sampling;Schedule;Serology;seropositive;Serotyping;Serum;Single Nucleotide Polymorphism;Structure;Surface;Teenagers;Testing;therapeutic vaccine;Time;Vaccination;Vaccine Antigen;vaccine development;Vaccines;Viral;Virion;Virus;Visit;Viviparous-1 protein;Wheezing

PROJECT_TITLE: Mechanisms of Enhanced Neutralizing Antibody Responses to Rhinovirus C

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The ciliary zonule, the system of fibers that suspends the lens, has an important role in the focusing mechanism of the healthy eye but is also adversely affected in a number of eye diseases. This project will examine the development of the zonule and investigate why mutations in genes encoding zonular proteins result in fiber rupture and lens dislocation.

PI_NAMEs: BASSNETT, STEVEN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Affect;Age;Aging;Atomic Force Microscopy;Biological;Biological Assay;Biology;Biomechanics;Blood Vessels;Cataract;Cells;crosslink;Development;Diagnosis;Disease;Distant;Dominant-Negative Mutation;Ectopia Lentis;Enzymes;Epithelial Cells;Epithelium;extracellular;Eye;Eye diseases;Failure;FBN1;Fiber;Fibrillin Microfibrils;Funding;Genes;Glaucoma;Glean;Goals;Growth;Human;human model;Image;In Vitro;Inherited;insight;Iris;Knockout Mice;Knowledge;Lead;lens;Lens dislocation;Lung Diseases;Marfan Syndrome;Materials Testing;Measures;mechanical stimulus;Mechanics;Modeling;Molecular;molecular marker;mouse model;Mus;mutant;Mutation;Myopia;null mutation;Optics;Pathology;Patients;Phenotype;Physiologic Intraocular Pressure;Play;postnatal;pressure;Proliferating;Property;Protein-Lysine 6-Oxidase;Proteins;Proteome;response;Retinal Detachment;Role;Rupture;S phase;Shapes;skin disorder;spatial relationship;Stains;Structure;Surface;System;Techniques;Tensile Strength;Testing;Thinness;three dimensional structure;transmission process;viscoelasticity;Visualization;Weill-Marchesani syndrome

PROJECT_TITLE: Structural, mechanical, and cell biological properties of the ciliary zonule

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: OVERALL NARRATIVE The Viral Immunity and Vaccination (VIVA) project will study factor leading to the generation of protective immune responses to vaccination against SARS CoV-2, influenza and dengue viruses in established human cohorts using state of the art immunological, genomic and data analysis tools. The outstanding team of investigators has ample expertise in virology, immunology, genomics and data analysis.

PI_NAMEs: FERNANDEZ-SESMA, ANA  (contact);SIMON, VIVIANA A

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Area;Argentina;Bioinformatics;Biological Assay;Biological Models;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Classification;Clinical;Clinical Trials;cohort;Collaborations;Communicable Diseases;Communities;Coupling;COVID-19 vaccination;COVID-19 vaccine;Cryopreserved Cell;Data;Data Analyses;data infrastructure;data management;data mining;data repository;Data Set;data standards;Dengue;Dengue Vaccine;Dengue Virus;Development;Differentiation Antigens;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemic;experimental study;Flow Cytometry;Foundations;Frequencies;Genbank;Generations;Genes;Genomic approach;genomic data;Genomics;Goals;holistic approach;Human;human disease;Immune;Immune response;Immune system;Immunity;Immunization;Immunoglobulins;Immunologic Memory;immunological status;Immunologics;Immunology;in vivo;Individual;Infection;Influenza A virus;Influenza B Virus;influenza infection;Influenza vaccination;influenzavirus;Innate Immune Response;Investigation;Learning;live attenuated influenza vaccine;Longitudinal cohort;Lymphoid Tissue;Maintenance;Maps;Measures;Mediating;Metadata;Methods;Modeling;Morbidity - disease rate;mortality;mosquito-borne;network models;next generation;novel;pandemic disease;pathogen;pathogenic virus;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Physicians;Physiological;Plasma;Population;Population Characteristics;predictive modeling;Prevention strategy;programs;Public Health;Qualifying;Research Personnel;Respiratory Tract Infections;response;Sampling;SARS coronavirus;Scientist;seasonal influenza;Seasons;sequencing platform;Serology;Serotyping;single-cell RNA sequencing;Source;Standardization;System;Techniques;Technology;Testing;Tissues;Tonsil;tool;transcriptomics;Vaccinated;Vaccination;vaccination outcome;vaccine candidate;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;vaccinology;Validation;Viral;Viral Antigens;Viral Pathogenesis;virology;Virus;Virus Diseases;World Health

PROJECT_TITLE: Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)


NIH_SPENDING_CATS: Immunization;Prevention;Vaccine Related

PI_NAMEs: FERNANDEZ-SESMA, ANA  (contact)

PROJECT_TERMS: Accountability;Address;Articulation;Collaborations;Communication;Data;data sharing;Decision Making;design;direct application;Doctor of Philosophy;Ensure;Environment;experimental study;flexibility;Funding Opportunities;Future;Goals;Human;Immunity;Immunology;Infrastructure;Institution;Laboratories;lectures;Manuscripts;medical schools;meetings;member;Microbiology;Monitor;National Institute of Allergy and Infectious Disease;New York;organizational structure;Performance;Policies;Preparation;Principal Investigator;programs;Progress Reports;Readiness;Reagent;Recommendation;Reporting;Research;Research Activity;Research Personnel;Resource Allocation;Resources;Role;Sampling;Services;Strategic Planning;symposium;Time;United States National Institutes of Health;Vaccination;Viral

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Sexual minority youth experience pronounced mental health disparities in terms of depression and suicidality. These disparities may be related to circumstances associated with the sexual minority identity development process, which primarily occurs during adolescence; however, these processes and relations are poorly understood. The proposed research is relevant to public health because it will advance our understanding of sexual minority identity development and mental health, and the findings will inform the development of evidence-based interventions to support sexual minority youth during challenges that arise during identity development.

PI_NAMEs: HALL, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adolescence;Age;Anxiety;Area;Awareness;Calendar;Chronology;clinical practice;combat;Communities;Complex;Confusion;coping;Coping Skills;Data;Data Analyses;data visualization;Depressed mood;Development;Developmental Process;Disparity;Distress;Emotional;emotional experience;ethnic identity;Ethnic Origin;Event;evidence based guidelines;Evidence based intervention;experience;Face;Family;Feeling suicidal;Friends;Funding;gender minority group;Guidelines;health data;health disparity;Health Professional;Healthy People 2020;Heterogeneity;Homophobia;Hostility;innovation;Institute of Medicine (U.S.);interest;Intervention;Interview;Knowledge;Label;Lesbian Gay Bisexual;LGBT Health;Life Cycle Stages;life history;Liquid substance;Literature;Major Depressive Disorder;Mental Depression;Mental Health;Mental health promotion;Methods;Modeling;Modernization;mosaic;non-heterosexual;Outcome;Parents;Pathway interactions;Patient Self-Report;Pattern;peer;Persons;Population;prevent;Prevention;Process;Public Health;queer;Race;Reaction;Recommendation;recruit;Regression Analysis;Religion;Reporting;Research;Resources;Risk;Sampling;satisfaction;Schools;self esteem;Sex Orientation;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority youth;Shame;Social Environment;social media;social stigma;social stress;Societies;statistics;Stigmatization;Stress;Stress and Coping;success;suicidal;Suicide;Suicide attempt;Techniques;Technology;Testing;theories;trend;United States National Institutes of Health;Variant;Visual;Voice;Youth

PROJECT_TITLE: Charting Trajectories of Sexual Identity Development and Mental Health Disparities Among Sexual Minority Youth

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Patient Safety;Pneumonia and Influenza;Prevention;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: SIMON, VIVIANA A (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;Adenovirus Vector;Argentina;biobank;Biological;Biological Specimen Banks;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Collection;Communicable Diseases;Conduct Clinical Trials;COVID-19;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;Cryopreservation;Data;Data Analyses;Data Collection;data management;Data Set;Dengue Vaccine;Dengue Virus;Enrollment;Ensure;follow-up;Genomics;Health system;healthy volunteer;Hospitals;Human;human pathogen;human subject;human subject protection;Immune;Immune response;Immunity;Immunization;Immunization Programs;Immunology;Individual;Infection;Influenza;Influenza vaccination;influenza virus vaccine;influenzavirus;Infrastructure;interest;International;Lead;Measures;Medical;medical schools;Messenger RNA;Mission;Modality;New York City;Observational Study;Operations Research;Participant;participant enrollment;pathogenic virus;Pathology;patient oriented;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Population;Prevention strategy;Protocols documentation;Public Health Schools;recruit;Research;Research Personnel;sample collection;Sampling;SARS-CoV-2 infection;seasonal influenza;Serum;Services;Source;Specimen;Standardization;Time;Tissues;Tonsil;Tonsillectomy;Vaccination;Viral;virology

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Aftercare;Antibody Response;Assessment tool;base;Binding;Biological Assay;Cells;chemokine;Clinical;Cohort Studies;Collaborations;Coronavirus;COVID-19 vaccine;cytokine;Data;Data Analyses;data management;Data Set;Dengue Virus;Deposition;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;genomic data;Genomics;Goals;Human;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Techniques;Immunology;Individual;Infection;influenza virus vaccine;influenzavirus;instrument;Laboratories;Letters;Measures;Mission;participant enrollment;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Process;Protocols documentation;Reagent;Resolution;response;Sampling;Serology;Serum;Services;Standardization;System;Techniques;Testing;Time;Tonsil;tool;transcriptome sequencing;transcriptomics;Vaccinated;Vaccination;vaccine immunogenicity;Vaccinee;Vaccines;Viral;Viral Antigens;Virus

PROJECT_TITLE: Immune Phenotyping Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: SEBRA, ROBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Address;analysis pipeline;breakthrough infection;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Clinical;cohort;Collaborations;Coupling;COVID-19 vaccine;Custom;cytokine;Data;Data Analyses;data analysis pipeline;data integration;data management;Data Set;Databases;Dengue Vaccine;Dengue Virus;Development;differential expression;Flow Cytometry;Fostering;Gene Expression Profile;Generations;Genes;genetic signature;Genetic Transcription;genomic data;Genomics;Human;Immune;Immune response;Immunity;Immunization Programs;Immunology;Immunophenotyping;Individual;Infection;Inflammatory Response;Influenza A virus;Influenza B Virus;influenza virus vaccine;Informatics;Lymphoid Tissue;Metadata;Methods;Modeling;Molecular;Multiomic Data;multiple omics;multiscale data;Natural Immunity;Outcome;Participant;pathogen;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Population;protein expression;Proteins;Quality Control;Resolution;Resources;seasonal influenza;Serology;System;Technology;Time;Tissue-Specific Gene Expression;Tissues;Tonsil;transcription regulatory network;transcriptome sequencing;transcriptomics;Vaccinated;Vaccination;vaccination outcome;vaccine immunogenicity;vaccine response;Vaccinee;Vaccines;Variant;Viral;Viral Genome;viral genomics;Virus Diseases

PROJECT_TITLE: Genomics Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed studies address an important and under-investigated area of childhood developmental stuttering pertaining to neural network development. The results from this research are expected to have an important positive impact, by identifying neural network markers apt to predict eventual persistence versus recovery during early phases of symptom progression up to adolescence. This may, in turn, guide clinical practices in terms of prioritizing intervention and as well as provide developmentally appropriate areas to consider in preventive and therapeutic interventions for childhood stuttering.

PI_NAMEs: CHANG, SOO-EUN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Age;Area;Auditory;Basal Ganglia;base;Behavioral;Brain;brain based;Brain imaging;Child;Childhood;Childhood Stuttering;clinical practice;Cognitive;cognitive development;Communication;Compensation;Complex;Data;data acquisition;Data Collection;data collection site;Data Set;Dentate nucleus;Development;Developmental Stuttering;Discrimination;Disease;DNA;Emotional;emotional factor;Functional Magnetic Resonance Imaging;Future;Gestures;Goals;innovation;insight;Intervention;Investigation;Knowledge;Language;large datasets;large scale data;Left;Link;longitudinal dataset;Longitudinal Studies;Maps;Measures;Mental Health;Motor;Motor Cortex;multimodal neuroimaging;neural network;Neurobiology;neuroimaging;Occupational Health;Outcome;Pattern;peer;Perception;Performance;Phase;preventive intervention;Process;Production;prognostic tool;programs;Protocols documentation;Publishing;putamen;Recovery;Reporting;Research;Research Personnel;Resources;Role;Site;Speech;Structure;Stuttering;support network;Symptoms;Task Performances;Taxes;Temperament;Testing;Therapeutic Intervention;trait;verbal;white matter

PROJECT_TITLE: A longitudinal study of neural network development in children who stutter

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: SLOBOGEAN, GERARD  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Angiography;Award;Budgets;career;Chlorhexidine;Clinical;Clinical Data;clinical practice;Clinical Trials;Clinical Trials Network;Conduct Clinical Trials;Data;Data Analyses;data quality;Data Set;Dedications;Development;educational atmosphere;Enrollment;Ensure;Environment;experience;Exposure to;Fracture;Funding;Future;high standard;imaging modality;Indocyanine Green;Institution;Lasers;Lead;Local Anti-Infective Agents;Mentors;Mentorship;Methods;Multi-Institutional Clinical Trial;Multicenter Trials;next generation;Operative Surgical Procedures;Orthopedics;patient oriented research;Patients;Philosophy;Pilot Projects;Productivity;programs;prospective;Randomized, Controlled Trials;recruit;Research;sample fixation;Scientist;secondary analysis;Soft Tissue Injuries;support network;Surgeon;tibia;Time;Training;Translations;Trauma;trial comparing;trial design

PROJECT_TITLE: Development of orthopaedic surgeon-scientist expertise in patient-oriented research

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: KRAMMER, FLORIAN  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Adenovirus Vector;Adenoviruses;Antibodies;Antibody Response;Antigens;Area;Argentina;Autoantibodies;Biological;Biological Models;booster vaccine;breakthrough infection;cell type;Cells;chemokine;climate change;Clinical;cohort;Country;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;cytokine;Cytometry;Data;Data Analyses;data dissemination;data management;Dose;Epidemic;experience;exposed human population;Gender;Genes;Genomics;Global Change;Human;Immune;Immune response;Immunity;Immunization;Immunology;Individual;Infection;Innate Immune Response;International;longitudinal analysis;Longitudinal cohort;Measures;Mediating;Messenger RNA;metropolitan;Molecular;new outbreak;New York City;next generation sequencing;novel vaccines;pandemic disease;pandemic potential;pathogenic virus;pathogens of pandemic potential;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Preparation;Research Activity;response;RNA;RNA vaccine;Sampling;sequencing platform;Serology;Serum;severe COVID-19;side effect;Specimen;Techniques;Time;Tonsil;Vaccination;vaccination outcome;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine-induced antibodies;Vaccinee;Vaccines;vector-based vaccine;Viral;Virus;Work;World Health

PROJECT_TITLE: Immune phenotyping of human immune responses to SARS CoV-2 vaccination and infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: GARCIA-SASTRE, ADOLFO  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adult;Antibodies;Antibody Response;B-Lymphocytes;biomarker identification;Blood;Cells;Cessation of life;chemokine;Circulation;Clinical;cohort;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Data Analyses;data management;Dedications;Defect;Dengue Infection;Effectiveness;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemic;exposed human population;Exposure to;Flow Cytometry;Genetic Transcription;Genomics;Health;Human;Immune;immune activation;Immune response;Immunity;Immunologic Factors;Immunologic Memory;immunological status;Immunology;Immunophenotyping;imprint;in vivo;Individual;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;Innate Immune Response;innovation;Lifting;Longitudinal cohort;Measures;Molecular Profiling;multiplex assay;Output;Pathway interactions;Patient Recruitments;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;Predisposition;public database;recruit;Recurrence;Reporting;Research;Respiratory Tract Infections;response;Sampling;SARS-CoV-2 infection;seasonal influenza;Seasons;Serology;Serum;System;T cell response;Techniques;Technology;Tonsil;transcriptomics;Vaccination;vaccine platform;vaccine response;Vaccinee;Vaccines;Viral;Virus

PROJECT_TITLE: Immune phenotyping of responses to influenza virus vaccination and infection


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Gene Therapy;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE This project will identify gene regulatory elements that enable selective expression of activity modulators and sensors in specific neuronal populations using recombinant adeno-associated viral vectors (AAV). The novel AAV vectors developed during the course of this proposal will be screened and evaluated for their ability to enable the study and modulation of specific disease-related circuits multiple in vivo and in vitro models of human disease.

PI_NAMEs: DEVERMAN, BENJAMIN E;FISHELL, GORDON J (contact);WANG, YATING

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: adeno-associated viral vector;Animals;Biological Models;blood-brain barrier crossing;Brain;brain cell;brain circuitry;Callithrix;Capsid;Carrying Capacities;cell type;Cells;cholinergic;Collaborations;Complex;Corpus striatum structure;Data;Dependovirus;Development;Disease;Engineering;Enhancers;Enterobacteria phage P1 Cre recombinase;Epilepsy;Evolution;Exhibits;expression vector;Functional disorder;Gene Expression;Genes;Genetic;Genetic Enhancer Element;genetic manipulation;high throughput screening;Human;human disease;human induced pluripotent stem cells;human model;in vitro Model;in vivo;Individual;Injections;Interneurons;Intravenous;Macaca;Maps;Mental disorders;Methods;Mus;Nature;Neurons;neuroregulation;nonhuman primate;novel;optogenetics;Organoids;Performance;Phase;Population;Prosencephalon;rabies viral tracing;Reagent;Recombinant adeno-associated virus (rAAV);Recombinants;Regulatory Element;Safety;screening;selective expression;sensor;Specificity;success;Target Populations;Technology;Testing;transgene expression;Transgenic Mice;Validation;vector;Viral;Virus;Visual Perception

PROJECT_TITLE: Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: adaptive immune response;Admixture;Aftercare;Architecture;Area;Attenuated;Biological Assay;Biology;Cells;Cellular Assay;Cellular Immunity;Clinical;Clinical Trials;Data Analyses;data management;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Development;Disease;Dissociation;Elements;Exanthema;Flow Cytometry;Formulation;Generations;Genetic;genetic approach;Genomics;Homo;Human;Humoral Immunities;imaging approach;Immune;Immune response;Immunity;immunogenicity;Immunologics;Immunology;Individual;Infection;Innate Immune Response;Knowledge;Lead;Modeling;mosquito-borne;Peripheral Blood Mononuclear Cell;Phenotype;Population;protective efficacy;response;Sampling;Serology;Serotyping;Structure of germinal center of lymph node;Suspensions;Time;Tissue imaging;Tonsil;transcriptomics;United States National Institutes of Health;Vaccination;vaccine development;vaccine efficacy;vaccine formulation;vaccine immunogenicity;vaccine trial;Vaccinee;Vaccines;Viral;Viremia;virology;Virus;Visualization

PROJECT_TITLE: Immune phenotyping of human immune responses to dengue vaccination and challenge


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

PI_NAMEs: VAN BAKEL, HARM  (contact)

PROJECT_TERMS: 2019-nCoV;analysis pipeline;Antibodies;Biological Assay;Blood;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Clinical;Code;cohort;Communities;computational pipelines;Computer Analysis;Consultations;cost;COVID-19 vaccine;cytokine;Cytometry;Data;Data Analyses;data infrastructure;data integration;data management;data repository;Data Set;database of Genotypes and Phenotypes;Dengue Virus;Ensure;Enzyme-Linked Immunosorbent Assay;Genbank;Gene Expression;Gene Expression Profiling;Generations;Genetic Transcription;Genomic approach;genomic data;genomic profiling;Genomics;Goals;high throughput analysis;Human;Immune;Immune response;Immunity;Immunization;Immunology;in vivo;Individual;Infection;influenzavirus;Infrastructure;insight;Investigation;Joints;Knowledge;Longitudinal cohort;Lymphoid;Maps;Metadata;Methodology;Modeling;Molecular;novel;pathogen;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Plasma;Quality Control;response;Sampling;screening;Serology;single cell analysis;Site;spatiotemporal;Statistical Data Interpretation;Technology;Time;Tissues;Tonsil;tool;transcriptome sequencing;transcriptomic profiling;transcriptomics;Vaccinated;Vaccination;vaccination outcome;vaccine immunogenicity;Vaccines;Viral;Visualization

PROJECT_TITLE: Core E Data Management Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: High-grade gliomas are a common and incurable form of brain tumor in both children and adults. We have recently discovered that high-grade gliomas utilize an extracellular regulated protein for survival and this protein can remodel the tumor microenvironment to sustain glioma growth. The proposed work and experiments will seek to deepen our understanding of the unique functions and the role of this protein in brain tumors. This study will extend our knowledgebase on how this protein promotes glioma growth and to identify a beneficial therapeutic strategy for brain tumors and all other cancers that utilize this protein.

PI_NAMEs: AGNIHOTRI, SAMEER  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Apoptosis;attenuation;Biological Models;Biology;Blood - brain barrier anatomy;Brain Neoplasms;Cancer Etiology;cancer type;cell growth;Cells;Cessation of life;Characteristics;Child;childhood cancer mortality;Cre-LoxP;cytokine;Data;Defect;derepression;Development;Diffuse intrinsic pontine glioma;Event;Exhibits;experimental study;extracellular;Extracellular Domain;Extracellular Signal Regulated Kinases;Genetic Transcription;Glioma;Gliomagenesis;Growth;Growth Factor;Histone H3;Human;In Vitro;in vitro Model;in vivo;inhibitor;innovation;knock-down;Knowledge;knowledgebase;Lead;Long-Term Effects;Lysine;Macrophage;Malignant Neoplasms;MAP Kinase Gene;MAPK1 gene;MAPK3 gene;Methylation;Microglia;Modality;Modeling;Molecular;Mus;Mutation;neoplastic cell;nerve stem cell;Neuroglia;Neurosciences;novel;novel therapeutics;oligodendrocyte progenitor;Oncoproteins;Outcome;Paracrine Communication;Pathway interactions;patient derived xenograft model;patient population;pediatric patients;pharmacologic;Phosphorylation;Phosphotransferases;Population;precursor cell;Production;Proliferating;Proteins;Publications;Publishing;Radiation;Receptor Protein-Tyrosine Kinases;Regulation;Research;Role;Signal Transduction;small hairpin RNA;System;Testing;Therapeutic;Transactivation;transcriptome sequencing;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Variant;Work;Xenograft procedure

PROJECT_TITLE: Targeting extracellular signaling-regulated kinase 5 (ERK5) in brain tumors and their microenvironment


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Cells use a diversity of chemical nucleotide modifications to regulate genes, and scientists use them to create potent RNA vaccines and drugs, where such modifications often exert their effect by altering RNA folding to trigger additional changes. This underscores a need to determine how modified RNAs fold, but while computational folding is widely used, accounting for the effects of modifications warrants revising its many parameters via a multitude of costly and laborious UV melting assays. We will develop computational methods for rapid estimation of these parameters from alternative, high-throughput structure probing assays, to advance studies of the roles of modifications in cellular function and to accelerate engineering of efficacious RNA medicines.

PI_NAMEs: AVIRAN, SHARON  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Academy;Acceleration;Accounting;Adoption;Agreement;Algorithms;Area;base;Biological Assay;Biology;Biotechnology;Cell Physiology;Cells;Chemicals;Collaborations;Complex;Computer software;Computing Methodologies;cost;Data;Data Analyses;data mining;Data Set;data structure;Dedications;design;Development;Disease;Engineering;experimental study;Free Energy;Future;Gene Expression Regulation;Genes;genome-wide analysis;Goals;Half-Life;improved;Infrastructure;Innate Immune Response;insight;interest;Investments;Learning;Life;Link;Measurement;Medicine;melting;Messenger RNA;method development;Methods;Modeling;Modification;next generation sequencing;novel;Nucleotides;Optics;Parameter Estimation;Performance;Pharmaceutical Preparations;Play;Polishes;posttranscriptional;Probability;Publishing;rapid technique;rational design;Reporting;RNA;RNA Folding;RNA library;RNA Splicing;RNA Stability;RNA vaccine;Role;Science;Scientist;Specificity;Structure;Techniques;Therapeutic;Thermodynamics;Time;tool;Transcript;transcriptome;Translations;Untranslated RNA;Uridine;Validation;Work

PROJECT_TITLE: Prediction of nearest neighbor parameters for folding RNAs with modified nucleotides

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Microbiome;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Hazardous alcohol use (HAU) is associated with gut microbiome dysbiosis and separately, an increased risk of cardiovascular disease (CVD). Gut microbiome-derived metabolites, like trimethylamine-N-oxide (TMAO) have been linked as a diagnostic and prognostic indicator of CVD. The goals of this project are to evaluate the relationship between HAU-induced alterations in the gut microbiota and its’ metabolites (i.e., TMAO), changes in the host metabolome, endothelial dysfunction and CVD severity while investigating the potential therapeutic efficacy of gut microbiota-targeted therapies to improve cardiovascular health.

PI_NAMEs: SHARP, THOMAS E. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Adoptive Transfer;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol use disorder;Alcohols;American;Amines;Atherosclerosis;Attenuated;Basic Science;Biochemical;Biological Availability;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Carnitine;Cessation of life;Choline;Chronic;chronic alcohol ingestion;Clinical Research;Cognitive;comorbidity;Coronary heart disease;cost;Development;Diabetes Mellitus;Diagnosis;Diagnostic;dietary;Digestive System Disorders;Disease;Disease Progression;dysbiosis;egg;endothelial dysfunction;Fishes;Flavins;FMO3;Functional disorder;Goals;gut dysbiosis;gut microbiome;gut microbiota;Health;Health Care Costs;Health Status;Heart;Heart failure;heart function;Hepatic;Homeostasis;Hour;Hypertension;improved;Individual;Inflammation;inflammatory milieu;inhibitor;insight;Intestinal permeability;Link;Liver;Measurement;Meat;Mediating;Metabolic syndrome;metabolome;metabolomics;Metagenomics;microbiome;microbiota;Mixed Function Oxygenases;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;myocardial infarct sizing;Myocardial Ischemia;Neurons;Nitric Oxide;novel;novel therapeutic intervention;Outcome;oxidation;Oxides;Pathology;Patients;Physiological;Play;Predisposition;Production;Prognosis;prognostic indicator;psychosocial;Reperfusion Therapy;Research;Risk;Role;Series;Severities;Severity of illness;sex;targeted treatment;Techniques;Therapeutic;Thrombus;Treatment Efficacy;United States;Vascular Diseases

PROJECT_TITLE: Alcohol-induced Gut Dysbiosis and Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: WEST HENRIETTA

ORG_NAME: LIGHTOPTECH CORPORATION

PHR: Noninvasive imaging is the holy grail for clinical diagnosis. Current corneal imaging techniques lack the capability to visualize cellular structures in 3D. We propose to commercialize a dual-mode optical coherence tomography and Gabor-domain optical coherence microscopy imaging system to enable non-invasive, high-definition, wide field of view imaging of the cornea in 3D for clinical applications.

PI_NAMEs: CANAVESI, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Address;Affect;aged;Anterior eyeball segment structure;Area;Bilateral;Biopsy;Blindness;Cell Density;Cells;Cellular Structures;Characteristics;Clinic;Clinical;clinical application;Clinical Data;clinical diagnosis;Clinical Investigator;clinical translation;Collaborations;commercial application;commercialization;Confocal Microscopy;Cornea;Corneal Diseases;Data;data acquisition;Data Collection;data management;Developing Countries;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Disease Progression;Dry Eye Syndromes;Endothelial Cells;Evaluation;Eye;Eye Banks;Fuchs' Endothelial Dystrophy;Future;Glaucoma;Goals;Gold;Grant;Health;Image;Image Analysis;image guided;image processing;imaging capabilities;Imaging Device;imaging modality;imaging system;Imaging Techniques;Imaging technology;improved;in vivo;Infection;innovation;Innovation Corps;instrument;instrumentation;interest;Keratitis;Legal patent;Licensing;Machine Learning;Measurement;Measures;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Monitor;Morphology;mosaic;multidisciplinary;neurosensory;non-invasive imaging;novel;novel therapeutics;ocular surface;Ophthalmology;Optical Coherence Tomography;Optics;Pain;Pathology;Patients;Persons;Phase;phase 2 study;Prevalence;Process;programs;prototype;Qualifying;Research;Resolution;Retina;Rights;Sampling;Small Business Innovation Research Grant;standard of care;Standardization;Structure;Surveys;Systems Development;Technology;Thick;Thinness;Three-Dimensional Imaging;three-dimensional visualization;Time;Tissue Transplantation;Tissues;tool;tumor;United States;United States National Institutes of Health;Universities;Variant;Visual;Visual impairment;Visual System;Visualization;Visually Impaired Persons

PROJECT_TITLE: In vivo high-definition 3D corneal imaging


ORG_DEPT: PATHOLOGY

PHR: Project Narrative  The amazing collection of monoclonal antibodies with potent neutralizing activity against a broad range of HIV-1 isolates has stimulated great interest in their use for therapeutic and for prevention purposes, whether by passive administration or by long-term delivery with vectors such as adeno-associated virus. As use of such monoclonal antibodies in people increases, it will be important to understand the nature of different resistance mutations and the selective pressures driving certain types of sequence changes.

PI_NAMEs: DESROSIERS, RONALD C (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: adeno-associated viral vector;Amaze;Amino Acids;Antibodies;Antibody Response;Automobile Driving;B-Lymphocytes;Biology of HIV Infection;Carbohydrates;Categories;Cell Line;Characteristics;Collection;course sequence;Data Collection;Databases;Dependovirus;Deposition;Disadvantaged;env Gene Products;Evolution;glycosylation;HIV Envelope Protein gp120;HIV-1;HIV-2;Individual;Infection;interest;Journals;Knock-out;knowledge base;Laboratories;Length;Link;Macaca mulatta;Malawi;man;Membrane Glycoproteins;Monkeys;Monoclonal Antibodies;Nature;neutralizing antibody;neutralizing monoclonal antibodies;Paper;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Persons;Plasma;Polysaccharides;Predictive Factor;pressure;Prevention;Publishing;recombinant virus;Recombinants;resistance mutation;RNA;Role;Serine;simian human immunodeficiency virus;Site;Specificity;Testing;Therapeutic Uses;Threonine;Time;Variant;vector;Virion;virology;Virus;Work

PROJECT_TITLE: Functional Role of O-glycosylation of HIV-1

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Pannexins are membrane channels widely distributed throughout the human body and play important roles in inflammation and neurotransmission. Our research objective is to understand mechanisms of how pan- nexins function at a molecular level, which may lead to the design of novel pharmacological agents to treat inflammatory and neurological diseases.

PI_NAMEs: KAWATE, TOSHIMITSU  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adrenergic Receptor;Biological Assay;Blood Vessels;brain tissue;C-terminal;Caspase;Cell Line;Cell Membrane Permeability;cell type;Cells;chronic pain;Cryoelectron Microscopy;design;Disease;Electrophysiology (science);Extracellular Domain;Family;Foundations;G-Protein-Coupled Receptors;Genetic;Goals;Human body;Hypertension;Immune response;Inflammation;Inflammatory;inhibitor;innovation;insight;Ion Channel;Ion Channel Gating;knock-down;Knock-out;Knowledge;Ligands;Link;lymphatic vasculature;Mediating;Molecular;Molecular Conformation;N-Methyl-D-Aspartate Receptors;N-terminal;Nervous System Disorder;neurodevelopment;neurotransmission;novel;novel therapeutics;Papaverine;pharmacologic;Phospholipase A2;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Play;Post-Translational Protein Processing;Process;Protein Dephosphorylation;receptor;reconstitution;reconstruction;Regulation;Renal tubule structure;Research;Resolution;Role;screening;shear stress;Signal Pathway;Signal Transduction;Signaling Molecule;Stimulus;Structure;Synapses;Tissues;tool;Tumor Necrosis Factor Receptor;Tyrosine Phosphorylation

PROJECT_TITLE: Structure and Function of Pannexins: Activation Mechanism

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: STONY BROOK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Acute pain accompanies invasive surgical procedures and is often difficult to control, despite the use of analgesics such as morphine and cyclooxygenase inhibitors. Moreover, opioids present additional risks to surgical patients that cause complications, delay discharge, and can lead to addiction. This proposal will characterize the contribution of endocannabinoid metabolism toward postoperative pain and may lead to the development of novel opioid sparing analgesics.

PI_NAMEs: KACZOCHA, MARTIN  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 2-arachidonylglycerol;Absence of pain sensation;Acute;Acute Pain;addiction;Afferent Neurons;Anabolism;Analgesics;Arachidonate 5-Lipoxygenase;Arachidonic Acids;Attenuated;behavior measurement;cannabinoid receptor;cell type;Cells;Centers for Disease Control and Prevention (U.S.);chronic neuropathic pain;chronic pain;Clinical;Coupled;cyclooxygenase 1;Cyclooxygenase Inhibitors;Development;Dinoprostone;Eicosanoids;Endocannabinoids;endogenous cannabinoid system;Enzymes;Epidermis;experimental study;Failure;Foundations;genetic approach;Human;human tissue;Hydrolysis;Hydroxyeicosatetraenoic Acids;Immune;improved;inflammatory pain;inhibitor;insight;keratinocyte;knee replacement arthroplasty;Knockout Mice;Knowledge;Ligands;MAGL inhibitor;Measures;Mediating;Medical Care Costs;Metabolism;Modeling;Monoacylglycerol Lipases;Morphine;Mus;non-opioid analgesic;novel;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid abuse;opioid sparing;opioid use;Outcome;Outcome Study;Oxycodone;Pain;Pain management;Pathway interactions;Patient-Focused Outcomes;Patients;Perioperative;Peripheral;Persons;pharmacologic;Population;Postoperative Pain;Postoperative Period;pre-clinical;Prescription drug overdose;Prevalence;Productivity;Property;Prostaglandin-Endoperoxide Synthase;Publications;Receptor Activation;Reporting;Risk;Rodent;Role;Sampling;Site;Skin;Surgical incisions;Surgical Models;Testing;Tissues;translational potential;Translations;United States;Vicodin;Work

PROJECT_TITLE: Endocannabinoid Metabolism in Acute Pain

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Sleep Research;Telehealth

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Attention-Deficit/Hyperactivity Disorder (ADHD) is a chronic condition that emerges early in life yet is rarely identified or treated during early development. Current preschool ADHD treatments are limited by barriers to access, inconsistent impact on core ADHD symptoms, and a primary focus on daytime behaviors, when ADHD may be best understood as a 24-hour disorder. The proposed project evaluates the effectiveness of PASS (Preschool Sleep and Attention Support), a behavioral telehealth intervention, in enhancing attention, behavior, and sleep among preschoolers identified as high risk for ADHD in the pediatric primary care setting.

PI_NAMEs: LUNSFORD-AVERY, JESSICA RUTH (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;age group;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior Therapy;Behavioral;behavioral health;behavioral sleep intervention;Caregivers;Child;Child Rearing;Childhood;Chronic;Clinical;clinical care;Clinical Trials;Cognition;comorbidity;critical developmental period;Development;Disease;early childhood;Early identification;Early Intervention;Early treatment;Effectiveness;effectiveness evaluation;Environment;evidence base;expectation;Focus Groups;follow-up;Foundations;functional outcomes;Health Personnel;high risk;Hour;Impairment;improved;improvement on sleep;Individual;Intervention;intervention delivery;Life;Life Cycle Stages;life span;Measures;Medicine;Mental Health;Morbidity - disease rate;Nursery Schools;Outcome;parenting intervention;Parents;physical conditioning;post intervention;Preparation;Primary Care;primary care setting;prospective;Public Health;Randomized, Controlled Trials;Reporting;Research Personnel;Risk;Risk Factors;Sampling;School-Age Population;Science;Severities;Shapes;skills;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep regulation;Societies;Stress;Symptoms;System;telehealth;Time;Toddler;Training;treatment effect;treatment trial;Work;Youth

PROJECT_TITLE: Preschool Attention and Sleep Support (PASS): A Telehealth Intervention for Children at Risk for ADHD


NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

PHR: NARRATIVE High-mobility group box 1 (HMGB1) has a recognized role in platelet activation and thrombosis formation, but its mechanism of platelet activation in sickle cell disease remains unclear. I propose that circulating hemoglobin oxidizes HMGB1 to trigger an intracellular platelet signaling cascade that potentiates platelet mitochondrial reactive oxygen species (mtROS) and platelet activation. Investigating this novel mechanism of platelet activation will improve our understanding of the mechanisms linking hemolysis and inflammation to platelet activation and thrombosis, and establish a foundation for developing and applying HMGB1-inhibitors to prevent thrombotic complications in sickle cell disease.

PI_NAMEs: NOLFI-DONEGAN, DEIRDRE  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Advisory Committees;Attenuated;Blood;Blood Platelet Disorders;Blood Platelets;Blood Vessels;career;career development;Cells;Complex;Cysteine;Data;Development;Development Plans;Disease;Disulfides;Electron Transport;Environment;Erythrocytes;Event;Experimental Models;ferric chloride;Foundations;Generations;Genetic Diseases;Haptoglobins;Heme;Hemoglobin;hemoglobin polymer;Hemolysis;Hemopexin;high risk;HMGB1 gene;Human;Hypoxia;improved;in vivo;Incubated;Inflammation;Inflammation Mediators;Inflammatory;Infusion procedures;inhibitor;Institute of Medicine (U.S.);Knock-out;Life;Link;Mass Spectrum Analysis;Measurement;Measures;Mediating;Membrane Potentials;Mentors;Mentorship;Mitochondria;Molecular;mouse model;multidisciplinary;Mus;mutant;new therapeutic target;novel;oxidation;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Pattern;Plasma;Platelet Activation;Platelet aggregation;Play;Polymers;prevent;Production;Proteins;Pulmonary Hypertension;Reactive Oxygen Species;receptor;Receptor Signaling;Recombinants;Research;Research Personnel;Respiration;Risk;Role;Sickle Cell Anemia;Sickle Hemoglobin;Signal Pathway;Signal Transduction;Sterility;Stimulant;Stimulus;Stroke;Sulfhydryl Compounds;Surface;synergism;Therapeutic;therapeutic target;Thrombosis;thrombotic;thrombotic complications;Thrombus;TLR4 gene;Training;Transgenic Mice;Universities;Work

PROJECT_TITLE: Mechanisms of platelet stimulation in hemolysis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Organelle dysfunction and compromised membrane protein quality control are hallmarks of neurodegenerative disorders. This proposal investigates the molecular mechanisms that collaborate to ensure high-fidelity membrane protein localization and topology. Molecular-level insights into these fundamental protein biosynthetic and quality control processes are necessary to understand how neurodegenerative diseases develop and identify effective treatments.

PI_NAMEs: SHAO, SICHEN  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;ATP phosphohydrolase;Binding;Biogenesis;Biological Assay;Biosynthetic Proteins;Cell Physiology;Cell Surface Receptors;Cells;Cellular Membrane;Client;Collaborations;Cytosol;Defect;Degradation Pathway;Disease;Dislocations;Dissection;effective therapy;Endoplasmic Reticulum;Ensure;Face;Functional disorder;Goals;Health;Homeostasis;Human;Huntington Disease;Hydrophobicity;Impairment;insight;Ion Channel;Knowledge;life span;Mediating;Membrane;Membrane Proteins;Mitochondria;Mitochondrial Membrane Protein;Mitochondrial Proteins;Modeling;Molecular;N-terminal;Neurodegenerative Disorders;Neurons;Neurotransmitters;Organelles;Organism;Parkinson Disease;preservation;Process;Protein Biosynthesis;Proteins;Proteome;proteostasis;Quality Control;Reaction;Ribosomes;Role;secretory protein;Site;Sorting;Surface;Synaptic Vesicles;System;Tail;trafficking;Transmembrane Domain;transmission process;Triage

PROJECT_TITLE: Quality control of mislocalized membrane proteins

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  The recent advances in high-throughput sequencing technologies enable cost-effective characterization of the immune system and provide novel opportunities to study adaptive immune receptor repertoire (AIRR) at the population scale. In this study, we will develop robust and scalable bioinformatics tools and databases to leverage the largest dataset covering individuals of various ancestries composed of over half a million NGS samples. The availability of large and ethnically diverse sets of samples will allow us to discover novel population- specific immune alleles and clonotypes and will enhance our understanding of human adaptive immune responses across heterogeneous and admixed populations.

PI_NAMEs: ALACHKAR, HOUDA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;aggregation database;Algorithms;Alleles;Autoimmune Diseases;B-Cell Antigen Receptor;B-Lymphocytes;Benchmarking;Bioinformatics;bioinformatics tool;Biological Assay;Cataloging;Certification;Collection;Communicable Diseases;Communities;cost effective;Data;Data Science;Data Set;Databases;deep sequencing;DNA amplification;ethnic diversity;Ethnic Population;European;European ancestry;Genes;Genetic;genetic architecture;genomic tools;health disparity;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;human disease;Immune;immune health;Immune system;Immune System Diseases;Immunogenetics;Immunogenomics;Immunologic Receptors;improved;Individual;Information Dissemination;Information Systems;insight;International;Malignant Neoplasms;Medical;Methods;Neurodegenerative Disorders;next generation sequencing;novel;Population;Population Heterogeneity;receptor;Reduce health disparities;RNA;Sampling;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;Technology;tool;transcriptome sequencing;Variant

PROJECT_TITLE: Developing robust and scalable genomics tools and databases to analyze immune  receptor repertoires across diverse populations

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Racial and ethnic minoritized youth with prior juvenile justice system contact experience significant health and legal inequities that persist into adulthood, but the impact of structural factors on these inequities is unknown. Project EPICC-2 examines the impact of structural racism and discrimination and interaction with individual, familial and extrafamilial influences on longitudinal health and legal inequities among ethnoracial youth with prior justice contact. Leveraging an existing adolescent longitudinal dataset, pre-existing relationships with justice-impacted families, an intersectional lens and intergenerational approach, this study will inform public health and criminal justice interventions to dismantle structural racism and reduce health and legal inequities for justice-impacted youth and families.

PI_NAMEs: TOLOU-SHAMS, MARINA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: adjudication;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Risk Behavior;adolescent substance use;Adult;Age;behavioral health;Caregivers;Complex;convict;court;Criminal Justice;Data;Data Reporting;Development;Discrimination;Disparity;Distress;Economics;Enrollment;Equity;ethnic minority;Ethnic Origin;ethnoracial;ethnoracial minority;experience;Family;follow up assessment;Future;Gender;Health;health care availability;health disparity;health inequalities;Health system;HIV/STD;indexing;Individual;Inequality;Inequity;Intercept;intergenerational;Intervention;Interview;Justice;juvenile justice system;Legal;Legal system;lens;Life Cycle Stages;longitudinal dataset;Longitudinal Studies;Measurement;Measures;Mental Health;minority children;multidisciplinary;Outcome;Participant;Patient Self-Report;Population;primary outcome;prospective;protective factors;psychiatric symptom;Public Health;public health research;Race;racial disparity;racial minority;racism;recidivism;Research;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Sampling;Science;service utilization;Services;sex;Sexism;sexual and reproductive health;Shapes;Socioeconomic Status;structural determinants;Structural Racism;Subgroup;substance misuse;substance use;System;theories;Time;traumatic stress;treatment services;Woman;young adult;Youth

PROJECT_TITLE: The Impact of Racism on Trajectories of Substance Use, Mental Health and Legal System Contact from Adolescence to Young Adulthood


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat drug abuse and addiction is critically dependent on fundamental understanding of brain networks altered by drugs of abuse and associated signaling pathways. The research described in this proposal will establish a new system to study how cannabinoid signaling impacts intact brains at cellular resolution that culminate in affecting elemental motivated behavior. If successful, it will pave a way to uncover principles of neural circuit development and dynamics, bridge a critical gap between molecules and systems impact associated with drugs of abuse, and shape policy and treatment strategies for drug abuse disorders.

PI_NAMEs: GUO, SU  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Ablation;Address;Affect;Animals;Anti-Anxiety Agents;approach behavior;avoidance behavior;Behavior;Behavioral;Brain;brain cell;Brain region;Calcium;Cannabinoids;Cannabis policy;cell type;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;Complex;computational platform;Corticotropin-Releasing Hormone;Cues;Darkness;Data;Dependence;Development;Diagnosis;Disease;Drug abuse;Drug Addiction;drug of abuse;Elements;endocannabinoid signaling;Endocannabinoids;Enzymes;exogenous cannabinoid;fitness;Food;Foundations;Frequencies;Functional Imaging;Future;Genes;Genetic;Genetic Models;genetic regulatory protein;Glutamates;Head;Human;Hypothalamic structure;Image;imaging platform;Immune;improved;in vivo calcium imaging;interest;Knock-in;knockout animal;Life;Ligands;Light;Lipids;Mammals;model organism;Molecular;Monitor;motivated behavior;Motivation;Motor;Motor Activity;Movement;Mus;neural;neural circuit;Neurons;Neuropeptides;Neurotransmitters;optogenetics;Outcome;Pathway Analysis;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Policies;postsynaptic;preference;Property;Proteins;Public Health;receptor;Receptor Inhibition;Receptor-Interacting Protein;Regulation;Research;Resolution;Resources;response;Rewards;Role;Sensory;sensory stimulus;Shapes;Signal Pathway;Signal Transduction;Slide;social;Specificity;Stimulus;Stress;stressor;System;Tail;Testing;Time;tool;treatment strategy;Vision;Zebrafish

PROJECT_TITLE: Role of endocannabinoid signaling in a preference/aversion circuitry


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: Arlington

ORG_NAME: ISA ASSOCIATES, INC.

PHR: PROJECT NARRATIVE This project aims to develop a culturally tailored, web-based obesity intervention training for promotores. Comadres Saludables is a highly scalable training approach that will provide promotores with the self-efficacy, knowledge, skills, and tools needed to effectively implement an obesity intervention for Hispanic women in the community. The proposed training is designed for use by community health centers, large metropolitan health centers, and community organizations that employ promotores to address Hispanic health.

PI_NAMEs: RIOS, DEBRA  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adopted;Age Years;Attitude;Behavior;behavior change;Behavioral;Belief;Benchmarking;bilingualism;Body mass index;Cardiovascular Diseases;Cessation of life;Chronic;Communities;Community Health Aides;community organizations;cost;Data;demographics;design;Development;diet and exercise;Disease;Disparity;E-learning;Economic Factors;Educational Curriculum;Educational Intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;eHealth;Electronic Mail;Ensure;Ethnic Origin;Evidence based practice;Exercise;Family;field study;Goals;Health;Heart;Hispanic;Hispanic Populations;Hispanic Women;implementation intervention;improved outcome;indexing;Intervention;intervention delivery;Investments;Knowledge;Latina;Learning;lifestyle intervention;Malignant Neoplasms;Marketing;Measures;Medical Care Costs;men;metropolitan;mHealth;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;obesity prevention;obesity treatment;Online Systems;Overweight;overweight adults;Participant;Patient Self-Report;Persons;Phase;Physical activity;physical inactivity;Population;post intervention;premature;programs;prototype;Public Health;Race;Randomized;Randomized, Controlled Trials;Recipe;Reduce health disparities;Research;Risk Behaviors;Risk Factors;Role playing therapy;satisfaction;Self Efficacy;Services;skills;social;Social Interaction;Social support;Spanish/English;successful intervention;Tablets;Target Populations;Technology;Test Result;Text Messaging;theories;Time;tool;Trainers Training;Training;Training Programs;Underserved Population;Unhealthy Diet;waist circumference;Weight

PROJECT_TITLE: Comadres Saludables: A Web-Based Promotora Training Program for Obesity Prevention in Hispanic Women


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Kidney transplant can be a valuable treatment option for older adults with kidney failure; however, the prerequisite physical and psychosocial evaluation process can entail substantial burdens for older adults and many will not ultimately receive a kidney. To ensure that the approach to care during this evaluation process aligns with the values and goals of individual patients, we propose a research agenda that will strengthen shared decision-making for older adults considering referral for kidney transplant evaluation. Together with an integrated career development plan, this work will also support Dr. Catherine Butler's transition to becoming an independent physician scientist whose research focuses on making the kidney transplant evaluation process more person-centered and equitable.

PI_NAMEs: BUTLER, CATHERINE R (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;Attention;Award;Bioethics;career development;Caring;Clinical;clinical encounter;cohort;Cohort Studies;Communication Tools;comorbidity;Complex;Consumption;Data;Decision Making;design;Development;Development Plans;Dialysis procedure;early experience;Electronic Health Record;Environment;Epidemiology;epidemiology study;Equity;Evaluation;experience;Exposure to;Family member;Fostering;Foundations;Future;Goals;Hares;Health system;Healthcare Systems;human old age (65+);improved;Individual;individual patient;innovation;insight;International;Intervention;Interview;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Life Expectancy;member;Mentors;Methodology;Methods;multidisciplinary;older adult;Operations Research;Patients;person centered;Physicians;Pilot Projects;pilot test;Positioning Attribute;Predisposition;Process;Professional Organizations;psychosocial;Qualitative Methods;Qualitative Research;racial minority status;Randomized, Controlled Trials;Research;Research Design;Research Institute;Retrospective cohort study;Risk;Sampling;Scientist;screening;Shapes;shared decision making;Structure;System;Testing;Time;tool;tool development;Training;transplant centers;Transplantation;Transplantation Surgery;Treatment outcome;Uncertainty;Universities;Wait Time;Waiting Lists;Washington;Work

PROJECT_TITLE: Strengthening Shared Decision-Making for Older Adults with Kidney Failure Considering Kidney Transplant


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Novel strategies are urgently needed to shorten the duration of tuberculosis (TB) treatment in HIV-infected and uninfected individuals. The current proposal will test the ability of a novel vaccine to boost T-cell immunity against the key TB stringent response factor RelMtb, which is needed for the bacteria to become less sensitive to antibiotics, with the goal of shortening treatment and preventing relapse in a standard mouse TB infection model. In order to transition our findings to the clinical setting, we will test the vaccine’s ability to induce antigen-specific T-cell responses in rhesus macaques, and measure RelMtb-specific T-cell responses using clinical samples from a longitudinal cohort of HIV-infected and uninfected patients receiving treatment for pulmonary TB in South Africa.

PI_NAMEs: KARAKOUSIS, PETROS C (contact);MARKHAM, RICHARD B.

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acceleration;Adjuvant;Adoptive Cell Transfers;Aerosols;Animal Model;Animals;antibiotic tolerance;Antibiotics;Antibody titer measurement;antigen-specific T cells;Antigens;Antitubercular Agents;Archives;Bacteria;Biological;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cellular Immunity;chemokine;Clinical;Collaborations;Communicable Diseases;cytokine;Dendritic Cells;Development;diagnostic tool;Dinucleoside Phosphates;DNA;DNA Vaccines;Dose;Drug resistance in tuberculosis;Enzyme-Linked Immunosorbent Assay;Enzymes;Flow Cytometry;Goals;Growth;Histologic;HIV;HIV Infections;Homeostasis;Human;Immune response;Immunity;Immunize;immunogenicity;Immunology;improved;In Vitro;Individual;interest;Interferon Type I;International;Intramuscular;isoniazid;Longitudinal cohort;Lung;Macaca mulatta;Measures;Microbiology;Modeling;Molecular Biology;Monitor;mouse model;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nature;novel;novel diagnostics;novel strategies;novel vaccines;Pathway interactions;Patients;Pattern;Periodicity;Persons;Pharmaceutical Preparations;Physiological;Plasmids;Positron-Emission Tomography;Pre-Clinical Model;Predisposition;primary endpoint;protective efficacy;Pulmonary Inflammation;Pulmonary Tuberculosis;Regimen;Relapse;relapse prevention;Reporting;Research Personnel;response;Role;Sampling;South Africa;South African;Stains;Stimulator of Interferon Genes;Stress;Subunit Vaccines;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;translational potential;treatment duration;Treatment Efficacy;Treatment Protocols;Tuberculosis;tuberculosis treatment;Tuberculosis Vaccines;Vaccination;vaccination strategy;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine platform;vaccine strategy;Vaccine Therapy;X-Ray Computed Tomography

PROJECT_TITLE: Therapeutic vaccination to augment stringent response-specific T-cell immunity to MTB persisters