ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Obesity;Physical Activity;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: MANHATTAN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative The proposed research is relevant to public health because it will advance our understanding of the feasibility, acceptability, and preliminary effectiveness of a novel park-based PA intervention in adults with SMI. This project is relevant to the mission of NIH and the National Institute of Mental Health because it will 1) improve physical activity and reduce cardiometabolic risk in SMI populations, and 2) identify novel implementation and dissemination processes and mechanisms by utilizing local parks and certified peer specialists (CPSs) to deliver the PA intervention within existing mental health services. This study will lay the foundation for large-scale effectiveness trials, which can lead to improvements in PA and reduction of cardiometabolic health disparities in adults with SMI.

PI_NAMEs: BESENYI, GINA  (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: acceptability and feasibility;active control;Adherence;Administrator;Adult;Aerobic Exercise;Age;American;Antipsychotic Agents;behavior change;behavioral health;Body fat;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Certification;Chronic Disease;Clinical;Communities;Community Mental Health Services;Data;depressive symptoms;Diabetes Mellitus;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness trial;evidence base;Evidence based intervention;Exercise;exercise intervention;experience;Face;feasibility testing;fitbit;fitness;Focus Groups;Foundations;Future;General Population;Goals;Health behavior and outcomes;Health care facility;health disparity;Health Personnel;Healthcare Systems;Heart Diseases;improved;innovation;Intervention;intervention refinement;Interview;Life;Life Cycle Stages;Light;Link;Major Depressive Disorder;Measures;Mediation;Medicaid;Medicare;Mental disorders;Mental Health;Mental Health Services;Mission;Modeling;moderate-to-vigorous physical activity;modifiable risk;Moods;Morbidity - disease rate;mortality;National Institute of Mental Health;novel;novel strategies;Obesity;Outcome;Participant;peer;Peer Group;Personality;Persons;Physical activity;Physical Fitness;physical inactivity;Population;post intervention;primary outcome;Process;programs;Protocols documentation;Provider;psychologic;Public Health;Quality of life;Recommendation;Recovery;Research;Research Personnel;resistance exercise;Resources;Risk Factors;satisfaction;scale up;Schizophrenia;schizophrenia spectrum disorder;secondary outcome;Self Efficacy;Services;severe mental illness;social;social cognitive theory;social disparities;Social support;Specialist;Stress;Stretching;system-level barriers;Technology;Testing;Training;United States National Institutes of Health;waist circumference;Walking

PROJECT_TITLE: Physical Activity to Reduce Cardiometabolic Risk in Adults with Serious Mental Illness (PARCS Study)


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE Extracellular vesicles can be used to treat various diseases, but their inherent heterogeneity and low yield have prevented them from easily translating to the clinic. Here we will synthesize scalable nanoparticles from the bottom up that mimic the effects of natural vesicles. The proposed research will create an effective platform for designing and testing extracellular vesicles with high efficacy.

PI_NAMEs: CARNEY, RANDY ;TAN, CHEEMENG  (contact);WANG, AIJUN

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;analytical method;angiogenesis;Animals;Autoimmune Responses;Benchmarking;Biodistribution;Biological;Biological Assay;Biological Models;Cell secretion;cell type;Cells;Cellular Assay;Chemicals;Clinic;clinical application;Complex;Coupled;delivery vehicle;design;Disease;Dose;Drug Delivery Systems;Engineering;Evaluation;Exhibits;Experimental Autoimmune Encephalomyelitis;experimental study;extracellular vesicles;Future;Half-Life;Heterogeneity;high throughput screening;Image;Immune;immunoregulation;In Vitro;in vivo;in vivo Model;insight;Integral Membrane Protein;intercellular communication;interest;Lead;Lipids;Liposomes;Mass Spectrum Analysis;Measurement;Membrane;Membrane Proteins;Mesenchymal;Mesenchymal Stem Cells;Methods;MicroRNAs;mimetics;Molecular;mouse model;Multiple Sclerosis;nanolitre;nanoparticle;Nervous System Disorder;Neurons;neuroprotection;Nucleic Acids;Organ;Performance;pharmacokinetics and pharmacodynamics;Physiologic pulse;Play;prevent;Printing;Production;Protein Biosynthesis;Proteins;Proteomics;prototype;public health relevance;Quality Control;Recombinants;reconstitution;regenerative;Reproducibility;Research;Resolution;RNA;Role;Set protein;Standardization;stem;Stromal Cells;superresolution microscopy;synthetic biology;System;Technology;Testing;Therapeutic;Therapeutic Effect;Toxic effect;transcriptome sequencing;Translating;unilamellar vesicle;Untranslated RNA;uptake;Vesicle;Wild Type Mouse;Work

PROJECT_TITLE: Bottom-up, high-throughput prototyping of extracellular vesicle mimetics using cell-free synthetic biology

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Each year, roughly 600,000 patients served in U.S. trauma centers develop posttraumatic stress disorder or depression after traumatic injury, but few receive mental health follow-up care. The Trauma Resilience and Recovery Program is a sustainable, stepped-care model that has addressed the mental health needs of over 8,000 patients in four Level I-II trauma centers and is being adopted by 8 additional trauma centers in the Carolinas. This study will examine the effectiveness and implementation of TRRP with a diverse sample of 350 patients served at The George Washington University hospital.

PI_NAMEs: RUGGIERO, KENNETH J (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Testing a Scalable Model of Care to Improve Patients’ Access to Mental Health Services after Traumatic Injury

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Methamphetamine;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Methamphetamine use and HIV infection share a common route of transmission (i.e., injection) and some common long-term adverse outcomes including impaired cognitive and immune functions. However, neither the specific types of cells nor the precise molecular causes of these outcomes are well understood, and little is known about how the effects of HIV and methamphetamine might exacerbate these symptoms. We will therefore use cutting edge genomic techniques to develop critical new insights into the human brain and its dysfunction in response to HIV and methamphetamine use.

PI_NAMEs: HO, YA-CHI  (contact);SESTAN, NENAD

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Address;adverse outcome;Amygdaloid structure;analysis pipeline;ATAC-seq;Atlases;Autopsy;Basic Science;Biological;Biological Assay;Biological Models;Biological Process;Biology;Brain;brain cell;Brain region;brain tissue;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Central Nervous System;Characteristics;ChIP-seq;Chromatin;Clinical Sciences;cognitive function;Collaborations;Communities;comorbidity;Complement;Complex;Confounding Factors (Epidemiology);Data;Data Analyses;data analysis pipeline;data centers;data quality;Data Set;data sharing;data standards;Detection;Disease;Drug abuse;Ensure;epigenetic regulation;Etiology;experimental study;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genomics;Genotype;global health;high risk population;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;immune function;Immune System Diseases;Immunohistochemistry;Impaired cognition;Impairment;in vivo;Individual;Injections;insight;Lead;Medial;Methamphetamine;methamphetamine use;Methamphetamine use disorder;methamphetamine user;Molecular;Molecular Profiling;Multiomic Data;Nervous System Disorder;Neurobiology;Neurocognition;neurogenomics;Neuroimmune;Neurosciences;novel;Nuclear;Nuclear RNA;Opioid;Organoids;Outcome;Pathway interactions;Patients;Population;Prefrontal Cortex;Process;Productivity;Protocols documentation;Public Health;Recording of previous events;Research;Research Personnel;Resolution;Resources;response;Risk;RNA;Route;Sampling;Science;single nucleus RNA-sequencing;Specific qualifier value;Symptoms;syndemic;Techniques;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transmission process;Transposase;Validation;Ventral Striatum;viral RNA

PROJECT_TITLE: M-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIV


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Human GABAB receptor and human calcium-sensing receptor are dimeric G protein-coupled receptors that mediate key biological phenomena including neurotransmission and Ca2+ homeostasis. Here we address the fundamental questions of how these receptors are activated by extracellular stimuli and how their functions are regulated. Defects in the signaling activities of these receptors are associated with disorders of the brain, bone and mineral metabolism, and our work will inform about the disease mechanisms and assist the design of novel therapeutic agents.

PI_NAMEs: FAN, QING R (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: addiction;Address;Anxiety;Behavior Disorders;Biological Phenomena;Blood;Bone Diseases;Brain Diseases;Calcium-Sensing Receptors;Central Nervous System;Cognitive;Coupling;Defect;design;Development;dimer;Disease;Epilepsy;extracellular;Extracellular Domain;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GTP-Binding Proteins;Homeostasis;Human;Hypercalcemia;Length;Life;Ligand Binding;Ligands;Mediating;Membrane;Metabolism;Minerals;Molecular;neurotransmission;novel therapeutics;Proteins;receptor;Receptor Activation;receptor function;Research;Signal Transduction;spasticity;Stimulus;Structural Models;Structure;synaptic inhibition;System;Therapeutic Agents;Transmembrane Domain;Work

PROJECT_TITLE: Molecular mechanism of dimeric G protein-coupled receptor signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative These studies take a stem cell-based view of tapeworm growth, regeneration, and reproduction with the potential to make discoveries about crucial aspects of tapeworm biology as well as broader discoveries in stem and germ cell biology. Completion of the proposed research could aid in the discovery of new drugs to combat diseases caused by these important parasites, which infect both humans and livestock. 1

PI_NAMEs: ROZARIO, TANIA  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adult;adult stem cell;analog;Anterior;Antibodies;Biological Assay;Biology;cell behavior;Cell Nucleus;Cell Separation;Cell Surface Receptors;Cell Transplantation;Cells;Cellular biology;Cessation of life;Cestoda;Cestode Infections;combat;Competence;Complex;Comprehension;Cues;Cyst;design;Detection;Development;Disease;Distress;drug development;Economics;fascinate;Feeling;Fresh Water;frontier;functional genomics;Future;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic approach;Germ Cells;Germ Lines;Goals;Growth;Hand;Head and neck structure;Helminths;Human;In Situ Hybridization;Injury;innovation;Intestines;Investigation;Label;Lethargies;Life Cycle Stages;Livestock;Longevity;Methodology;model organism;Modeling;Modernization;Molecular;Natural regeneration;Nature;Neck;Neoplasm Metastasis;Nervous System;novel therapeutics;Organ failure;Output;Parasites;pathogen;Pathologic;Physiological;Physiology;Planarians;Platyhelminths;Play;pluripotency;Pluripotent Stem Cells;Prevention;Rat tapeworm;regenerative;Regulation;Reproduction;reproductive;Research;RNA;RNA Interference;Role;screening;Seizures;Signal Transduction;Stains;stem cell biology;stem cell population;stem cells;stemness;Structure of primordial sex cell;Symptoms;System;Techniques;Testing;Thymidine;tissue repair;Tissues;tool;trait;Transcript;transcriptomics;transmission process;Transplantation;Work;Zoonoses

PROJECT_TITLE: Tapeworm stem cells as drivers of regeneration and reproduction


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) is a major unmet clinical need given its substantial burden of morbidity and mortality and absence of effective therapies. The prevalence of HFpEF is significantly higher among women than men and emerging data suggest that sex differences in inflammatory pathways may contribute to the female susceptibility to HFpEF. To improve our limited understanding of the pathogenesis of HFpEF, we will study upstream mediators of inflammation as they relate to clinical precursors and HFpEF outcomes in men vs women.

PI_NAMEs: LAU, EMILY  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Advisory Committees;Affect;Age;Anti-Inflammatory Agents;biological sex;Biometry;Cardiac;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Career Mobility;Clinical;clinical heterogeneity;cohort;Communities;comorbidity;Complex;Data;design;Development;Disease;disease heterogeneity;Disease Progression;effective therapy;EFRAC;Eicosanoids;Endothelial Cells;endothelial dysfunction;Endothelium;Exercise;exercise intolerance;Female;Future;Gene Expression Profiling;Goals;Heart failure;hemodynamics;Heterogeneity;High Risk Woman;Hospitals;Human;Immune response;Impairment;improved;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;insight;Investigation;Knowledge;Light;Lipids;longitudinal, prospective study;Mass Spectrum Analysis;Mediator;men;Mentorship;metabolomics;Methods;Molecular;Morbidity - disease rate;mortality;Nested Case-Control Study;novel;Obesity;Observational Study;Outcome;Pathogenesis;Pathway interactions;patient oriented research;Patients;Perimenopause;Phenotype;Physicians;Physiological;Postmenopause;Predisposition;Premenopause;preservation;Prevalence;Prevention;Program Development;prospective;Public Health;Research;Research Personnel;Research Proposals;response;Risk;Role;Scientist;sex;Sex Differences;skills;Stress;Structure;Symptoms;systemic inflammatory response;Techniques;Technology;Therapeutic;Time;transcriptomics;United States;Validation;valsartan;Venous;Woman;women versus men;Women's Health;Women's prevalence;Work

PROJECT_TITLE: HFpEF Susceptibility in Women: The Role of Inflammation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Clinical Research;Endocrine Disruptors;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The Yupik people of St. Lawrence Island are disproportionately affected by hazardous contaminants from formerly used defense sites that harm their lands, waters, traditional foods, health and well-being; they are also affected by the long-range transport of pollutants into the Arctic. This study addresses a primary environmental public health concern through investigation of the nature, extent, biological effects, and human health implications of contamination from the formerly used defense site at Northeast Cape on St. Lawrence Island, a major defense installation dating from the Cold War era that left a legacy of hazardous waste such as polychlorinated biphenyls (PCBs), pesticides, and mercury. The research will inform remediation decisions and public health assessments, and provide data and implement actions necessary for re-establishing the displaced traditional community at Northeast Cape, as well as serve as a model for improving health outcomes of arctic communities broadly.

PI_NAMEs: BUCK, CHARLES LOREN;BYRNE, SAMUEL ;CARPENTER, DAVID ORLO;MILLER, PAMELA KAY;SALAMOVA, AMINA ;VON HIPPEL, FRANK ARTHUR (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Advocate;Affect;air sampling;Alaska;Arctic Regions;Biological;Biota;Blood;Body Burden;cancer risk;Communities;community based participatory research;community collaboration;Computerized Medical Record;Consultations;Consumption;Data;Decision Making;DNA biosynthesis;DNA Methylation;DNA Repair;Endocrine;Engineering;Ensure;Equity;estrogenic;Exhibits;exposure pathway;Exposure to;Fishes;Food;Gasterosteidae;Glean;Goals;Guidelines;Hair;Hazardous Waste;Health;health assessment;Health protection;Histopathology;Hormones;Human;Hypothyroidism;improved;Indigenous;indigenous community;Ingestion;Inhalation;International;Intervention;Investigation;Knowledge;Left;male;Measurement;member;Mercury;Metabolic;Military Personnel;Modeling;Monitor;Names;Nature;Organ;organochlorine pesticide;Outcome;Participant;persistent organic pollutants;Personal Satisfaction;Persons;Pesticides;Physiological;Policies;pollutant transport;Polychlorinated Biphenyls;Public Health;Recording of previous events;remediation;Research;Sampling;Scientific Advances and Accomplishments;Sentinel;Serum;Signal Transduction;Site;Soil;Source;St. Lawrence Island;Tissue-Specific Gene Expression;Vitellogenins;War;Water;Work;Yup'ik

PROJECT_TITLE: Restoring Northeast Cape for the Health and Well-Being of the Yupik Communities of St. Lawrence Island, Alaska


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Osteoarthritis (OA) is a highly prevalent degenerative joint disease for which there is no cure or effective therapy. Oxidative stress plays a key role in the development and progression of OA, however conventional antioxidants have had limited therapeutic success due to poor stability and bioavailability. This research aims to overcome these limitations to OA therapy, by engineering a nanomaterial with antioxidant properties that effectively reduces oxidative stress in cartilage and reduces inflammation to improve joint structure and function.

PI_NAMEs: SHARMA, BLANKA  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Affect;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;antioxidant enzyme;Antioxidants;Arthralgia;arthropathies;Artificial nanoparticles;Behavioral Assay;Benchmarking;Biochemical;Biological;Biological Availability;bone;Cartilage;Cells;Characteristics;Chondrocytes;chondroprotection;Clinical;cost;cytokine;Degenerative polyarthritis;delivery vehicle;design;Development;disability;Disadvantaged;Disease;disease model;Disease Progression;Dose;effective therapy;efficacy evaluation;efficacy testing;Engineering;Enzymes;extracellular;Extracellular Matrix;Face;gait examination;Histologic;Human;human tissue;immunogenicity;improved;In Vitro;in vivo;Inflammation;Inflammatory;Intra-Articular Injections;joint destruction;joint function;joint injury;Joints;Location;longitudinal analysis;Macrophage;Manganese;Mediating;Modeling;Monitor;Morphology;Motivation;nanomaterials;nanoparticle;nanoparticle delivery;Natural regeneration;novel strategies;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pain;particle;Pathogenesis;Pathway Analysis;Pathway interactions;Phenotype;Play;preservation;prevent;Production;Property;protein degradation;Rattus;Reactive Oxygen Species;reduce symptoms;Regimen;Reporting;Research;Rodent;Role;Signal Transduction;small molecule;Source;Structure;success;Symptoms;Synovial Fluid;Tactile;targeted agent;Testing;Therapeutic;therapeutic target;therapy outcome;Tissues;transcriptome sequencing;Translations;Traumatic Arthropathy;treatment response;treatment strategy;uptake;Work

PROJECT_TITLE: ROS scavenging nanoparticles for mitigating oxidative stress in osteoarthritis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Patients with advanced chronic kidney disease (CKD) suffer from widespread tissue injuries and develop markedly increased blood levels of phosphate and fibroblast growth factor 23 (FGF23). We have experimental evidence suggesting that phosphate and FGF23 can directly target the heart and cause pathologic changes in cardiac structure and function. In this research proposal, we will determine how phosphate and FGF23 act on heart tissue and whether FGF23 made by heart muscle cells can cause CKD-associated heart injury, which would suggest that CKD patients might benefit from therapies tackling phosphate and FGF23.

PI_NAMEs: CAMPOS, ISAAC D (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Adenine;Anemia;Animal Model;Biological Markers;Blood;bone;calcification;Calcineurin;Cardiac;Cardiac Death;Cardiac Myocytes;Cardiovascular Diseases;Cell Surface Receptors;cell type;Cells;Cessation of life;Chronic Kidney Failure;Co-Immunoprecipitations;Control Animal;coronary fibrosis;cytokine;design;Development;Diet;Disease;Drug Targeting;Echocardiography;Ensure;Epidemic;Event;experimental study;extracellular;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Fibrosis;Gene Expression;Genes;Growth;Health;Heart;heart damage;Heart Diseases;Heart Hypertrophy;Heart Injuries;Histologic;Hormones;Hypertrophy;in vivo;Inflammation;Inflammatory;Injury;inorganic phosphate;Inorganic Phosphate Transporter;Integral Membrane Protein;Kidney;Knock-out;Link;Metabolism;Minerals;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Analysis;Morphology;mortality;mortality risk;mouse model;Mus;novel;novel therapeutic intervention;nuclear factors of activated T-cells;osteogenic;paracrine;Pathologic;Pathology;Patients;pharmacologic;phospholipase C gamma;Positioning Attribute;premature;prevent;Production;programs;protein function;Protein Isoforms;PTH gene;receptor;renal damage;Reporting;Research Proposals;Risk;Rodent;Rodent Model;Serum;Severity of illness;Signal Transduction;Smooth Muscle Myocytes;Source;Structure;systemic inflammatory response;Testing;Time;tissue injury;Tissues;Tubular formation;uptake;Vascular calcification;Vascular Smooth Muscle;Vitamin D;Western Blotting;Work

PROJECT_TITLE: Hyperphosphatemia Contributes to Cardiac Injury in Chronic Kidney Disease


NIH_SPENDING_CATS: Aging;Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative Despite knowledge that age, germline mutations (e.g. BRCA1, BRCA2, or PALB2), and family history of cancer are all risk factors for breast cancer, understanding what makes one person more susceptible to this disease compared to another is not well known. We propose to leverage two remarkable discoveries we have made with our innovative microfluidic platform, mechano-Node-Pore Sensing (mechano-NPS) —breast epithelial cells from younger and older women have different mechanical properties, and cells from young women who are at very high risk of cancer because they carry a germline mutation appeared mechanically “older” than the women’s chronological ages—to develop a breast cancer susceptibility detection system, which will measure the “mechanical age” of a woman’s cells. Clinically useful genetic testing relies on a handful of known monogenic risk traits, but we hypothesize that emergent mechanical properties, measured from a few hundred cells, are a characteristic of the biology that underlies cancer susceptible states, even those that are polygenic or epigenetic in nature and are passed within a family but that have so far defied definition.

PI_NAMEs: LABARGE, MARK A;SOHN, LYDIA L (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Acceleration;Age;age acceleration;Aging;Biological Clocks;Biology;Biomechanics;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Detection;cancer initiation;Cell membrane;Cell Nucleus;Cell Surface Proteins;Cells;Cellular biology;Characteristics;Chronology;Cities;Classification;Clinical;Complex;Cytoskeleton;Data;design;Detection;detection platform;Devices;Diameter;Disease;Early Diagnosis;Educational process of instructing;Epigenetic Process;Epithelial Cells;Exhibits;experimental study;Family;Family Cancer History;Family history of;Funding;gene network;Generations;Genetic;Genetic Screening;genetic testing;genetic variant;Germ Lines;Germ-Line Mutation;high risk;High Risk Woman;High-Risk Cancer;Human;Immune;in silico;innovation;Intermediate Filaments;Knowledge;Machine Learning;machine learning classification;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Measures;mechanical properties;Mechanics;Microfluidics;Modeling;Molecular;molecular mechanics;molecular phenotype;Nature;new therapeutic target;non-genetic;older women;PALB2 gene;Pathway interactions;Patients;Persons;Phenotype;physical property;portability;Portraits;Predisposition;Property;Proteins;Publications;Publishing;response;Risk;Risk Estimate;Risk Factors;screening;Surface;System;Time;Tissues;tool;trait;Validation;Variant;virulence gene;Woman;Work;young woman

PROJECT_TITLE: Detection of Emergent Mechanical Properties of Biologically Complex Cellular States

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Food allergy is a serious and rapidly growing public health concern and the lack of a thorough understanding of disease mechanisms has adversely affected the development of highly effective therapies. Our proposed studies examine how a gut protein named resistin like molecule beta (RELMb) acts to disrupt immune tolerance to ingested foods to result in food allergy. We will also determine how targeting this protein can reset the immune system towards tolerance of ingested food allergens and these studies will allow the development of novel, effective therapies and prevention strategies to aid patients with food allergy.

PI_NAMEs: CHATILA, TALAL AMINE (contact);RAKOFF-NAHOUM, SETH

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Adult;Affect;Allergens;allergic response;Anaphylaxis;antagonist;Aryl Hydrocarbon Receptor;Cell Differentiation process;cell type;Cells;Child;commensal bacteria;cytokine;Dedications;Development;Disease;dysbiosis;effective therapy;Epithelial Cells;Epithelium;Evolution;Exhibits;Food;food allergen;Food Hypersensitivity;Frequencies;gastrointestinal epithelium;GATA3 gene;Genes;Genetic;Genetic Transcription;Goblet Cells;gut dysbiosis;gut microbiota;Helper-Inducer T-Lymphocyte;High Prevalence;human subject;IgE;Immune;Immune response;Immune system;Immune Tolerance;Immunologics;improved;Indoles;Ingestion;Innate Immune Response;insight;Interleukin-13;Interleukin-4;Lactobacillus;Life;Link;mast cell;Mediating;metabolomics;microbial;microbiota;Monoclonal Antibodies;mouse model;Mus;Names;novel;novel therapeutic intervention;Oral;oral immunotherapy;oral tolerance;Parasitic infection;Pathogenesis;Pathogenicity;Pathology;Patients;Phenotype;Play;Population;predictive marker;Predisposition;Prevention strategy;Production;programs;Proteins;Public Health;Reaction;receptor;receptor expression;Regulatory T-Lymphocyte;resistin;response;Risk;Role;segregation;Serum;Severity of illness;TSLP gene;Weaning

PROJECT_TITLE: Immunological and Microbial Mechanisms in Food Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT There continues to be a need for clinician scientists who are skilled in modern scientific methods and have the background to develop novel approaches to the diagnosis, treatment, and prevention of diseases affecting the heart, lungs, and blood over the entire life course. The proposed Duke NHLBI Scientist-Clinician-Investigator Stimulating access to Research during Residency (Duke NHLBI SCI-StARR) program provides dedicated research time to Resident-Investigators fromthe Departments of Pediatrics, Medicine, and Surgery to foster their maturation into independent physician-scientists who use cutting-edge methods of laboratory and clinical research to pursue long-term academic careers investigating important issues related to human health.

PI_NAMEs: ELMALLAH, MAI ;HARPOLE, DAVID H. (contact);PALMER, SCOTT M

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Achievement;Address;Affect;Applications Grants;Area;Award;Basic Science;Biomedical Research;Blood;Blood Vessels;Board Certification;Cardiopulmonary;Cardiovascular system;career;career development;Caring;Clinic;Clinical;Clinical Research;clinical training;clinical translation;Clinical Trials;Communication;Communities;Country;COVID-19 impact;Critiques;Data Science;Dedications;Development;Development Plans;Diagnosis;Disease;disorder prevention;Disparity;Drug Kinetics;early phase clinical trial;Education;Educational workshop;Eligibility Determination;Ensure;Evaluation;experience;Extramural Activities;Faculty;Fellowship;Fostering;Foundations;Funding;Goals;Grant;Health;health data;Healthcare;Heart;Heart Diseases;Hematological Disease;Human;implementation research;improved;Individual;Infrastructure;innovation;Institution;Journals;Laboratory Research;Life Cycle Stages;Lung;Lung Diseases;Manuscripts;Medical;medical schools;Medicine;meetings;Mentors;Mentorship;Methods;Mission;Modality;Modernization;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;next generation;novel diagnostics;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathway interactions;pediatric department;Pediatrics;Peer Review;Phase;Physicians;Physicians' Offices;Positioning Attribute;preference;prevent;Productivity;programs;Public Health;public health relevance;Request for Applications;Research;Research Personnel;Research Priority;Research Project Grants;Research Training;Residencies;Resources;response;Scholarship;Scientist;Signal Transduction;skills;Societies;Structure;Study Section;success;Time;tool;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Stimulating Access to Research in Residency (StARR) - NHLBI


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence

PHR: PROJECT NARRATIVE  Excessive alcohol use contributes to a wide range of negative health outcomes, including accidents, violence, alcohol dependence, and cardiovascular disease. Existing interventions to reduce alcohol use may not be appropriate for TNB people, both due to inapplicable and potentially unacceptable content (e.g., gender- specific drinking guidelines) and because they do not address anti-TNB stigma as a key determinant of alcohol use in this population. Relationship-focused interventions have the potential to jointly address alcohol use and co-occurring depression/anxiety symptoms in TNB people by reducing adverse relationship experiences (e.g., intimate partner violence) that result from stigma—and leveraging supportive romantic relationships as a buffer against the effects of stigma.

PI_NAMEs: MURCHISON, GABRIEL R (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Accidents;Address;Adult;Advocacy;Affect;Alcohol consumption;Alcohol dependence;alcohol intervention;Alcohols;Anxiety;anxiety symptoms;arm;Attenuated;Buffers;Cardiovascular Diseases;career;Clinical;Communities;community engaged intervention;community engagement;Data;Data Collection;Data Set;design;Development;diaries;Discrimination;drinking;Educational workshop;efficacy trial;Epidemiologist;Epidemiology;Evaluation;experience;Factor Analysis;Feasibility Studies;Feedback;Future;Gender;Goals;Guidelines;Health;improved;Intervention;Interview;intimate partner violence;Link;Measurement;Measures;Mediating;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Modeling;motivational enhancement therapy;nonbinary;online intervention;Outcome;Performance;Persons;Phase;Population;Process;Property;prospective;prototype;Psychometrics;Qualitative Methods;Qualitative Research;reduced alcohol use;Reporting;Research;Risk Factors;Role;satisfaction;Scientist;Series;Sexual and Gender Minorities;Shapes;Social Identification;social stigma;sound;Structure;Surveys;technology intervention;technology validation;Testing;therapy development;Training;transgender;usability;Violence;violence victimization;Work;young adult;young adult alcohol use

PROJECT_TITLE: Stigma, Romantic Relationships, and Alcohol Use Among Transgender and Nonbinary Young Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Narrative  This application will address important public health problems indirectly, through machine learning methods for inference in the presence of missing data and for causal mediation, and directly through constructing these methods to speciﬁcally address important reseach questions involving cardiovascular health in underdeveloped settings, weight management in behavioral studies, the impact of the type of bariatric surgery on weight and cancer outcomes, and pharmacoepidemiologic studies of diabetogenic risk in treatment of hypertension and mental disorders.

PI_NAMEs: DANIELS, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;Algorithms;bariatric surgery;Bayesian learning;Bayesian Method;Bayesian Modeling;behavior change;Behavioral Mechanisms;behavioral study;Behavioral trial;Blood Pressure;Body Weight;cardiovascular health;Cardiovascular system;Caring;Clinical;Clinical Research;Clinical Trials;Cluster randomized trial;Code;Collaborations;Comparative Study;Complex;Computer software;cost;Data;data complexity;Data Element;data modeling;Diabetes Mellitus;diabetogenic;Electronic Health Record;Ensure;Ethics;Exhibits;flexibility;Frequencies;Funding;Future;Hand;Heterogeneity;hypertension treatment;improved;Individual;interest;Intervention;Kenya;large datasets;Literature;longitudinal, prospective study;machine learning method;Malignant Neoplasms;Mediating;Mediation;Mediator;Mental disorders;Methodology;Methods;Modeling;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;Observational Study;Outcome;Paper;Pharmaceutical Preparations;Pharmacoepidemiology;primary outcome;Process;Property;prospective;Protocols documentation;Public Health;randomized trial;Recording of previous events;Research;Research Personnel;Risk;Sampling;Science;secondary outcome;Structure;Time;tool;Uncertainty;usability;virtual;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Bayesian machine learning for complex missing data and causal inference with a focus on cardiovascular and obesity studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Natural Products

ORG_CITY: ATLANTA

ORG_DEPT: DERMATOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE Regardless of the biological source (bacterial, fungal, plant, animal, or engineered organism), natural product scientists face a common bottleneck: structure elucidation of compounds found in complex mixtures. Here, we propose development and optimization of a micro-crystal electron diffraction platform technology for high- throughput compound identification with nanogram quantities of analytes found in natural mixtures.

PI_NAMEs: NELSON, HOSEA MARTIN;QUAVE, CASSANDRA LEAH (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acceleration;Algorithms;analytical method;Animals;Anti-Bacterial Agents;anti-fungal agents;atorvastatin;Automobile Driving;Bacteria;bioactive natural products;Bioinformatics;Biological;Cardiovascular Diseases;Chemicals;Code;Collection;Complementary Health;Complex;Complex Mixtures;Computer software;Crude Extracts;Cryoelectron Microscopy;Data;Data Analyses;Data Collection;Deposition;Development;Disease;Disparate;DNA Microarray Chip;Drug usage;economic impact;electron diffraction;Engineering;Eubacterium;Face;fungus;Goals;Health;high throughput technology;Human;Human Resources;hypocholesterolemia;Image;improved;Infection;innovation;Integrative Medicine;interest;Intervention;Location;Malignant Neoplasms;marine;marine organism;Microarray Analysis;Microbial natural product;mind/body;Modality;Modernization;Molds;nano;Natural product discovery;Natural Products;Natural Products Chemistry;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Nutrient;open source;Organism;Pain;Pain Measurement;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacopoeias;physical property;Plants;Population;Process;Property;Protista;Reporting;Research;Roentgen Rays;Safety;Sales;Sampling;Science;Scientist;signature molecule;Site;small molecule libraries;solid state;Source;Speed;stereochemistry;Structure;submicron;synergism;technology platform;Time;tool;Transmission Electron Microscopy;Validation;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Development and validation of a high-throughput MicroED-driven platform technology for natural product discovery


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The Indiana Pediatric Scientist Award (IPSA) K12 program will identify and develop a talented and diverse cohort of pediatric physician-scientists to carry out cutting-edge basic science and translational research to transform child and adolescent health. This program will leverage infrastructure and resources at the Indiana University School of Medicine and the Riley Hospital for Children to nurture the careers of the next generation of pediatric physician-scientist leaders.

PI_NAMEs: CLAPP, DAVID W (contact);EVANS-MOLINA, CARMELLA

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;adolescent health;Attention;Award;Basic Science;bench to bedside;career;Child;Child Health;Child health care;Childhood;Communicable Diseases;design;Development;Diabetes Mellitus;Disease;experience;Faculty;Foundations;Funding;gender diversity;Genetic Diseases;Goals;Indiana;Individual;Institution;interest;International;investigator training;Knowledge;Learning;medical schools;Mentors;Mentorship;multidisciplinary;next generation;Other Genetics;Pathogenesis;Pediatric cohort;pediatric department;Pediatric Hospitals;pediatrician scientist;Physicians;Positioning Attribute;programs;racial diversity;recruit;Research;research faculty;Research Personnel;Resources;Science;Scientist;Stretching;Structure;success;Talents;targeted treatment;Training;Training and Education;Training Programs;Translational Research;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Opioid use in adults including pregnant women has skyrocketed in recent years which led to the government's declaration of the opioid epidemic as a public health emergency in 2017. Newborns exposed to opioids prenatally are at high risk for developing a drug withdrawal syndrome known as Neonatal Opioid Withdrawal Syndrome (NOWS). In this proposal we will identify predictors of NOWS and chart the neurodevelopmental outcome of newborns with NOWS with the ultimate goal of developing tools that will allow clinicians to intervene early, improve care for these infants and improve their long term developmental outome.

PI_NAMEs: CONRADT, LIZ D;LESTER, BARRY M. (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Age;Birth;Caregivers;Characteristics;Child;Childhood;Clinical;Clinical Markers;clinical predictors;Cognitive;cohort;Collaborations;Crying;Data;design;Development;Diagnosis;Drug abuse;Drug Exposure;drug withdrawal;Enrollment;Environment;Epidemic;evidence base;Exhibits;Exposure to;feeding;fetal drug exposure;fetal opioid exposure;fetal substance exposure;follow up assessment;follow-up;Follow-Up Studies;Functional disorder;Funding;Goals;Government;Hair;Health;high risk;Hospital Charges;Hospitalization;Hospitals;Hour;human subject protection;Hyperactivity;Impairment;improved;in utero diagnosis;Incidence;infancy;Infant;Infant Care;insight;interest;intergenerational;Intervention;Language Development;Length of Stay;Life Style;Longitudinal Studies;Measures;Methods;Modeling;Motor;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;neurobehavior;neurobehavioral;neurodevelopment;Neurodevelopmental Impairment;Newborn Infant;Nonpharmacologic Therapy;novel;Opioid;opioid epidemic;opioid exposure;opioid use;Outcome;Participant;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;Policies;postnatal;predictive marker;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;prescription opioid;prevent;prospective;Protocols documentation;Psyche structure;public health emergency;Publishing;Recording of previous events;recruit;reduce symptoms;research clinical testing;Resources;retention rate;Rhode Island;Risk;Risk Behaviors;risk minimization;screening;Severities;Sex Differences;Site;Sleep;social health determinants;sociodemographic predictors;sociodemographics;socioeconomics;standard of care;Stress;substance use;Substance Withdrawal Syndrome;success;Symptoms;Testing;Time;tool;transmission process;Treatment Protocols;Tremor;United States;United States National Institutes of Health;Universities;Utah;Woman

PROJECT_TITLE: Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: As bacteria increasingly evade antibiotics that attack their cell walls, it is ever more crucial to understand the mechanisms by which bacteria monitor and repair their cell walls. This work identifies novel mechanisms by which bacteria can repair their cell walls during growth.

PI_NAMEs: COHEN, JENNIFER DARA (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Adaptive Immune System;Amino Acids;Antibiotic Therapy;Antibiotics;Area;Bacillus subtilis;Bacteria;Biochemical;Biogenesis;capsule;career;cell envelope;cell growth;Cell membrane;Cell Shape;Cell Wall;Cells;Cellular biology;Communities;Complement;crosslink;Cytolysis;Cytoprotection;Data;Defect;Disease;Encapsulated;Environment;Enzymes;experimental study;extracellular;Fellowship;Fortification;Future;Genes;Genetic Screening;Glycerophosphates;Goals;Gram-Positive Bacteria;Growth;Homologous Gene;Hydrolase;Immobilization;Immune;Innate Immune System;intercalation;Knowledge;Laboratories;Link;Lipids;lipoteichoic acid;Maintenance;medical schools;Membrane;Mentors;Microbiology;Modeling;Monitor;mutant;novel;Osmosis;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptides;Peptidoglycan;Polymers;Polysaccharides;Process;Proteins;Publishing;repaired;Research;Research Personnel;Role;Shapes;Signaling Protein;Specific qualifier value;Surface;Teichoic Acids;therapeutic development;Training;Transferase;Vaccine Therapy;virtual;Virulence Factors;Work

PROJECT_TITLE: Assembly and Maintenance of the Bacterial Cell Envelope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative (public health related) Seizure disorders (epilepsies) are very common and some children suffering from seizures also have autism and intellectual disabilities. In this proposal, we will use mutation-bearing mouse and cell models, including patient- derived cells, to in-depth study the disease mechanisms and test a novel rescue option via repairing impaired protein trafficking. Our goal is to design the most effective treatment option based on the specific patho- mechanisms and correct the problem at the root level.

PI_NAMEs: KANG, JING-QIONG  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Acids;Address;Affect;Alleles;Astrocytes;autism spectrum disorder;Biological Models;Brain;Calnexin;Cell Line;Cell model;Cell surface;Cells;Child;Childhood;Clinical Trials;Collaborations;comorbidity;Data;design;Disease;disease mechanisms study;Disease Outcome;disease phenotype;DNA Sequence Alteration;Dominant-Negative Mutation;effective therapy;Electroencephalography;endoplasmic reticulum stress;Epilepsy;extracellular;FDA approved;Foundations;Functional disorder;Future;GABA Transporter 1;gamma-Aminobutyric Acid;Genes;Genetic;Goals;Heterozygote;high throughput screening;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;inhibitory neuron;insight;Intellectual functioning disability;interdisciplinary approach;Intervention;Investigation;Knock-in Mouse;Letters;Libraries;loss of function;loss of function mutation;Measures;Mediating;Membrane;Microdialysis;misfolded protein;Molecular Chaperones;mouse model;Mus;mutant;Mutation;Neurodevelopmental Disorder;Neurons;new therapeutic target;Nonsense Mutation;novel;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;pharmacologic;Phase;Phenotype;phenotypic data;Phenylbutyrates;pilot trial;Plasmids;Pre-Clinical Model;programs;protein misfolding;protein transport;Proteins;Public Health;receptor;repaired;Research;Research Design;Research Methodology;scale up;Seizures;small molecule;success;Surface;Synaptosomes;Syndrome;Techniques;Testing;tiagabine;trafficking;Translating;uptake;Work

PROJECT_TITLE: Promoting Protein Trafficking with 4-phenylbutyrate to Treat Genetic Epilepsy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE The development of new approaches to enhance the therapeutic potential of autologous bone-forming cells will provide valuable and necessary options to clinicians treating bone defects, especially for cases of slow-healing or nonhealing damage, and cases that require minimal immune and other side effects. We seek to determine if applying novel programming methods to aggregates of progenitor cells, right before implantation, will enhance their reparative function for bone regeneration.

PI_NAMEs: LEACH, J. KENT (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adhesives;Adsorption;Affect;Age;Allogenic;Angiogenic Factor;Apoptosis;Autologous;Binding;Biological Assay;Biomimetics;BMP2 gene;bone;bone healing;Bone Regeneration;bone repair;Bone Transplantation;Cartilage;cartilage implant;cartilage transplantation;Cell Adhesion;Cell Differentiation process;cell growth;Cell Physiology;Cell secretion;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Chondrogenesis;Clinical;Cues;Data;Defect;Development;Disease;disease transmission;dosage;Excision;Exhibits;Extracellular Matrix;Fracture;Growth Factor;Growth Factor Receptors;healing;Health;Histology;Immune;Impairment;Implant;implantation;In Situ;In Vitro;Individual;innovation;Integrins;Intervention;intramembranous bone formation;life span;long bone;mesenchymal stromal cell;Methods;Mitogens;morphogens;Musculoskeletal;Natural regeneration;non-invasive imaging;novel;novel strategies;Osteogenesis;osteogenic;Outcome;Pathway interactions;Patients;Phenotype;Physiologic Ossification;Publishing;Quality of life;Recombinant Growth Factor;repair function;repaired;Research;response;Role;Safety;side effect;Signal Transduction;skeletal;spheroids;stem cells;synergism;Testing;Therapeutic;Tissue Engineering;Tissues;Transplantation;Trauma;tumor

PROJECT_TITLE: Identifying the superior ossification pathway for tissue engineered approaches to long bone repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE (PROJECT NARRATIVE)  The proposed research is relevant to public health because it provides detailed insight into the fundamental mechanism of mitochondrial fission, an essential process in cellular homeostasis. Consequently, mitochondrial division is misregulated in several diseases, leading to organelle dysfunction and eventually cell death. Therefore, the proposed research aims dissect the regulatory mechanisms that govern organelle division and the physiologic changes associated with altered mitochondrial morphology to identify novel therapeutic targets and inform future studies that advance disease diagnosis, treatment and prevention.

PI_NAMEs: MEARS, JASON  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: advanced disease;Aging;Apoptosis;Binding;Bioenergetics;Cardiovascular Diseases;Cell Death;cell injury;Cells;Child;cofactor;combinatorial;Complement;Complex;constriction;Core Assembly;Crista ampullaris;Cryoelectron Microscopy;Cues;Cytosol;Data;Defect;Degenerative Disorder;dimer;Disease;disease diagnosis;Dynamin;Electron Transport;Ensure;Evaluation;Event;experimental study;Frequencies;Functional disorder;Funding;Future;Genes;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Homeostasis;Impairment;improved;In Vitro;insight;Lesion;Lipid Binding;Lipids;Liquid substance;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Membrane;Metabolic stress;Methods;Mitochondria;mitochondrial membrane;Molecular;Molecular Conformation;Monitor;Morphology;Mutation;Nerve Degeneration;new therapeutic target;Nucleotides;Organelles;Outcome;Pathologic;Patients;Physiological;Physiology;Post-Translational Protein Processing;premature;prevent;Prevention;Process;Production;Property;Proteins;Public Health;public health relevance;Reactive Oxygen Species;reconstitution;recruit;Regulation;Research;response;Role;self assembly;Shapes;Signal Transduction;Site;Stains;Stimulus;Stress;Structure;Surface;System;targeted treatment;Tertiary Protein Structure;Therapeutic;therapeutic target;three dimensional structure;Time;time use;Visualization

PROJECT_TITLE: Defining Molecular Interactions that Drive Mitochondrial Fission

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative We will evaluate the role of the purinergic receptors P2rX4 in the survival and function of antibody-producing plasma cells. Our results should reveal novel strategies to deplete problematic and pathogenic plasma cells, and hence improve outcomes in autoimmunity and transplantation.

PI_NAMEs: ALLMAN, DAVID M (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;Aftercare;Alleles;Antibodies;Antibody Response;Antibody titer measurement;Apoptosis;Apoptotic;ATF6 gene;Autoantibodies;Autoimmunity;B-Lymphocytes;Binding;Biochemical;Blood Vessels;bone;bone loss;Bone Marrow;Bone Marrow Cells;Cations;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;chemokine;Connexins;Cre driver;Cues;Data;Disease;Elements;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Exposure to;extracellular;Family;Fostering;Health;Homeostasis;Homing;Host Defense;Human;Humoral Immunities;Immunoglobulin A;Immunoglobulin G;improved;improved outcome;In Situ;In Vitro;Infection;inhibitor;insight;Longevity;Mammals;Mediating;Metabolic;Mitochondria;Modeling;Mutagenesis;Mutation;Newborn Infant;novel strategies;Osteoblasts;Outcome;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Plasma Cells;Play;prevent;Process;Protein Biosynthesis;Purinoceptor;Regulation;response;restraint;Role;Serum;Signal Transduction;Source;Spleen;Stromal Cell-Derived Factor 1;Testing;transcription factor CHOP;Transplantation;Vaccination;Vaccines;Work;XBP1 gene

PROJECT_TITLE: Biochemical Mechanisms for Sustained Humoral Immunity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: OLD WESTBURY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK INST OF TECHNOLOGY

PHR: PROJECT NARRATIVE Although more than 170 RNA modifications have been identified so far, we only know the function of a few of these, mainly due to technological limitations. The goal of the proposed research is to bring the power of mass laddering technology from proteomics to RNA for developing a direct RNA sequencing and quantitative mapping tool for multiple RNA modifications at single-base resolution all in a single analysis, as a critical step toward elucidating their possible impact on human health.

PI_NAMEs: ZHANG, SHENGLONG  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: 2019-nCoV;Adopted;Affect;Algorithms;American;Automation;base;Base Sequence;Chemicals;Complementary DNA;Complex Mixtures;COVID-19;Defect;Development;Disease;disease model;empowerment;genome-wide;Goals;Health;High Fat Diet;High-Throughput Nucleotide Sequencing;Human;human disease;insight;instrumentation;Length;Location;Malignant Breast Neoplasm;Maps;Mass Spectrum Analysis;Metabolic Diseases;Methods;Modification;mouse model;Mus;Nature;next generation;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Obesity;pandemic disease;Phenylalanine-Specific tRNA;posttranscriptional;Preparation;prevent;Proteomics;Research;Resolution;Ribosomal RNA;RNA;RNA Sequences;Running;Sampling;scale up;Series;Site;Small RNA;stoichiometry;Techniques;Technology;Time;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Transfer RNA;Variant;Yeasts

PROJECT_TITLE: Development of Next-Generation Mass Spectrometry-based de novo RNA Sequencing for all Modifications


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative / Relevance Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. We propose to expand the work of the PGC so we can learn key lessons about the fundamental basis of major psychiatric disorders

PI_NAMEs: BULIK, CYNTHIA M;SULLIVAN, PATRICK F (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;base;biobank;Biological;Biology;Biotechnology;career;case control;Cells;Clinical;Collaborations;Communication;Communities;Country;Data;Diagnostic;digital media;Disease;DNA Resequencing;education resources;Educational Materials;Ensure;Epidemiology;exome;exome sequencing;experimental study;Facebook;Family;Fostering;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;Genets;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;improved;Individual;Industry;innovation;insight;Institution;instrument;Investments;Journals;Knowledge;Learning;Life;Maps;Measures;Medical;Medicine;Mendelian randomization;Mental disorders;Meta-Analysis;Methods;Mission;Modeling;Molecular;National Institute of Mental Health;Nature;Neurosciences;novel;novel therapeutics;Outcome;outreach;Paper;patient stratification;patient subsets;Patients;Phase;Phenotype;predict clinical outcome;Productivity;Psychiatric Diagnosis;psychiatric genomics;Psychiatry;rare variant;Recording of previous events;Reproducibility;Research Personnel;Resistance;Resources;Risk;Risk Factors;Science;Scientist;severe psychiatric disorder;Source;statistics;success;Symptoms;Therapeutic;therapeutic development;Time;translational potential;Twitter;Update;Variant;whole genome;Work;working group

PROJECT_TITLE: 1/7 PGC: Advancing Discovery and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project examines how being on cardiopulmonary bypass activates a severe inflammatory response that impairs the function of all most every organ in the body, especially in infants. We will test how a pro-inflammatory molecule is activated by bypass, how this molecule causes damage to organs, and if blocking this molecule reduces post-bypass inflammation/organ damage. The resulting data will be used to help new ways of protecting infants during cardiac surgery.

PI_NAMEs: DEL ALAMO, JUAN CARLOS ;NIGAM, VISHAL  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Adrenal Cortex Hormones;Animal Model;Biomechanics;Blood;Blood Cells;Bypass;Calcium;Calcium Signaling;candidate identification;Cardiac Surgery procedures;Cardiopulmonary Bypass;cell cortex;Cell Death;Cells;Cellular Structures;Cessation of life;Childhood;Clinical;Congenital Heart Defects;Critical Pathways;cytokine;Data;Drug usage;effectiveness evaluation;experience;experimental study;Exposure to;Functional disorder;Gene Expression;Goals;Health Care Costs;Impairment;improved outcome;In Vitro;in vivo;Infant;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Knowledge;Leukocytes;Lytic;Mediating;Mediator;Membrane;migration;Molecular;monocyte;Morbidity - disease rate;mortality;Myeloid Cells;Neonatal;neonatal patient;novel;novel strategies;Operative Surgical Procedures;Organ;Outcome;palliation;Pathway interactions;Patients;Pattern;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Plasma;Play;porcine model;preclinical development;Process;Protein-Serine-Threonine Kinases;Publishing;receptor;Receptor Activation;repaired;Research;response;RIPK3 gene;Role;shear stress;Signal Pathway;Signal Transduction;small molecule;STIM1 gene;systemic inflammatory response;Techniques;Temperature;Testing;Tissues;Translating;treatment strategy;Tube

PROJECT_TITLE: Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative: The major goal of this proposal is to investigate the role and underlying mechanism(s) of IGF2BP2 (a reader of RNA N6-methyladenosine) in MLL-rearranged (MLLr) acute myeloid leukemia (AML) pathogenesis and leukemia stem/initiating cell (LSC/LIC) self-renewal, and to also assess the therapeutic potential of pharmacological inhibition IGF2BP2 in treating MLLr AML. The success of this project will define the pathological function of IGF2BP2 in MLLr AML biology and provide profound novel insights into the complex mechanisms underlying MLLr AML pathogenesis and LSC/LIC maintenance, and may also lead to the development of effective novel targeted therapeutic strategies to treat MLLr AML. Therefore, our project is of great significance in both basic science and translational research.

PI_NAMEs: CHEN, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Accounting;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acute Promyelocytic Leukemia;Adolescent;adult leukemia;Arsenic Trioxide;Basic Science;Binding Proteins;Biology;bioprocess;cancer type;Cells;Childhood Leukemia;Chimeric Proteins;Chromosome abnormality;Complex;Cytogenetics;Data;Development;effective therapy;Exhibits;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Hematopoietic Neoplasms;Hematopoietic stem cells;improved;inhibitor;insight;Knowledge;Lead;leukemia;leukemia treatment;Maintenance;Medical;Messenger RNA;Mixed-Lineage Leukemia;MLLT3 gene;Modification;Molecular;Molecular Abnormality;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;pharmacokinetics and pharmacodynamics;pharmacologic;Play;posttranscriptional;Prognosis;Promoter Regions;Proteins;Reader;Relapse;RNA;Role;self-renewal;side effect;small molecule inhibitor;Solid Neoplasm;stem;Subgroup;success;Survival Rate;t(8;21)(q22;q22);targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Therapeutic Intervention;therapeutically effective;Toxic effect;Transcript;translational medicine;Translational Research;Translations;Treatment Efficacy;Treatment Failure;Tretinoin;Tumor Promotion

PROJECT_TITLE: The role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemia


NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Wound Healing and Care

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This project will define a newly recognized system for communication between the immune systems of the skin and gut. The work builds on the scientific premise that the exposure of intestinal stromal fibroblasts to hyaluronic acid fragments released from the skin enhances the capacity of these precursor cells to differentiate into adipocytes. The project will show how this process of reactive adipogenesis is important for antimicrobial defense and inflammation of the intestine.

PI_NAMEs: GALLO, RICHARD L (contact);SALZMAN, NITA H

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Address;adipocyte differentiation;Adipocytes;adipokines;Affect;Allergic inflammation;anti-microbial peptide;antimicrobial;Bacteria;Catabolism;cathelicidin;Cells;Chemicals;Clinical;clinically relevant;Communication;Cutaneous;Data;Dermal;Dermis;Digestion;Disease;Epithelium;Estrogen Receptors;experimental study;Extracellular Matrix;Fatty acid glycerol esters;fecal microbiome;Fibroblasts;genetic approach;Genetic Transcription;Gnotobiotic;Goals;gut inflammation;Host Defense;human tissue;Hyaluronan;Hyaluronic Acid;Hyaluronidase;Immune;immune function;Immune system;Immunity;immunological status;In Vitro;in vitro Model;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;injured;Injury;Innate Immune Response;innovation;Intervention;intestinal injury;Intestines;Keratin;lipid biosynthesis;Measures;Mediating;microbiome;Modeling;Mucous Membrane;Mus;Names;Outcome Assessment;Outcome Measure;Patients;Phenotype;precursor cell;Process;Reactive Inhibition;receptor;response;Role;Salmonella;Series;Severities;Severity of illness;Skin;skin disorder;Skin injury;Skin Tissue;Staphylococcus aureus;Stimulus;Stromal Cells;Submucosa;Surface;System;Testing;Work;wound

PROJECT_TITLE: Inflammatory cross-talk between skin and gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Tuberculosis, one of the world's most important diseases, with 10 million cases and 1.6 million deaths in 2017, is the leading cause of death from a single infectious agent worldwide (and among the top ten causes of all death). BCG, the currently administered vaccine against tuberculosis, is only partially effective. This proposal will apply a combination of novel strategies to develop a vaccine that is safer and much more potent than BCG, comprising a highly attenuated Mycobacterium tuberculosis engineered for precise control of its in vivo growth and clearance so as to maximize its immunoprotective response and simultaneously eliminate its capacity to disseminate in an immunocompromised host.

PI_NAMEs: HORWITZ, MARCUS AARON (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Aerosols;Affect;Animal Model;Attenuated;Attenuated Vaccines;attenuation;Bacille Calmette-Guerin vaccination;Bacteria;BCG Vaccine;booster vaccine;Cause of Death;Cavia;Cells;Cessation of life;Characteristics;Child;Childhood;Development;Disease;Dose;efficacy study;Engineering;Essential Genes;exhaust;expectation;Generations;Genes;Genetic;Goals;Growth;Heme Iron;Human;Immune response;Immunity;Immunization;Immunize;Immunocompetent;Immunocompromised Host;Immunodominant Antigens;immunogenicity;immunopathology;improved;In Vitro;in vivo;Individual;Infectious Agent;Inflammatory Response;Iron;iron metabolism;Knock-out;Licensing;Life;Mediating;Metabolic Clearance Rate;Modification;mortality;Mus;mutant;Mutation;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;novel;novel strategies;Organism;Pathway interactions;Persons;preservation;prevent;protective efficacy;Public Health;Pulmonary Tuberculosis;rBCG;Recombinants;response;Role;Safety;SCID Mice;Siderophores;System;T memory cell;T-Lymphocyte Epitopes;Testing;Time;Tuberculosis;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine development;vaccine immunogenicity;Vaccines;Virulence

PROJECT_TITLE: Development of a novel TB vaccine safer and more effective than BCG based on a precisely controlled replication-limited Mycobacterium tuberculosis engineered for optimal in vivo growth and clearance

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Several adult and pediatric cancers are driven by activating RET fusions/mutations which can be effectively treated by selpercatinib, a novel, FDA-approved selective RET inhibitor. Unfortunately, resistance to selpercatinib is both uncharacterized and a liability. This proposal seeks to computationally and preclinically characterize intrinsic and acquired mechanisms of genomic and non-genomic resistance to selective RET inhibition to identify therapeutic strategies that prevent or delay the development of resistance.

PI_NAMEs: DRILON, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Allelic Imbalance;Biological;Biopsy;Bypass;Cataloging;cell free DNA;Cells;Clinical;clinically relevant;Clonality;co-clinical trial;Collection;combinatorial;Combined Modality Therapy;Computer Analysis;Computing Methodologies;Data Set;deep sequencing;Dependence;disorder control;Drug Approval;Effectiveness;Evolution;exome sequencing;FDA approved;Future;Genetic;Genomics;Histologic;In Vitro;in vivo;inhibitor;inhibitor therapy;Kinetics;KRAS2 gene;Leadership;Lesion;Libraries;Life;Lung;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;MDM2 gene;Methods;model development;Modeling;Molecular;mutant;Mutation;Nature;next generation;non-genomic;novel;novel therapeutic intervention;Pathway interactions;patient biomarkers;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;Phase I/II Trial;PIK3CG gene;Plasma;pre-clinical;Pre-Clinical Model;prevent;programs;Progression-Free Survivals;prospective;Protocols documentation;Receptor Protein-Tyrosine Kinases;Resistance;Resistance development;resistance mechanism;Resources;responders and non-responders;response;RET inhibition;Role;Sampling;Signal Transduction;Therapeutic;Time;Tissues;Treatment Efficacy;tumor;tumor progression;Tyrosine Kinase Inhibitor;Validation

PROJECT_TITLE: Predicting sensitivity and resistance in RET-driven cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative This project is relevant to public health because it addresses a novel mechanism of mesenchymal lineage dysfunction and bone loss in aging. If successful, it will provide a scientific basis for development of new strategies to prevent and/or treat bone loss. It is also expected to advance the field of bone biology by elucidating yet unknown mechanisms connecting phagocytic activity of mesenchymal stromal cells, subsequent metabolic disruption, senescence and their dysfunction leading to decreased osteogenic capacity and bone loss. This is highly relevant to the NIH mission of developing fundamental knowledge that will help to reduce the burdens of human aging and disability.

PI_NAMEs: CALVI, LAURA M (contact);ELISEEV, ROMAN

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adult;age related;Aging;AMD3100;antagonist;antioxidant enzyme;Apoptosis;Apoptotic;BAI1 gene;Biology;biomechanical test;bone;bone aging;bone health;bone loss;Bone Marrow;Bone marrow failure;bone repair;bone turnover;catalase;Cell Aging;Cell Physiology;Cell Senescence Induction;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Trials;CXCL1 gene;CXCR4 gene;Data;Degenerative Disorder;Development;disability;Disease;Dose;drug repurposing;Flow Cytometry;Functional disorder;gain of function;Genetic Models;Genetic Recombination;Genetic Transcription;Goals;Health;Homeostasis;Human;IL8RB gene;Immune;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;innovation;Insulin-Like Growth Factor I;Interleukin-1;Interleukin-1 beta;Knowledge;Label;Longevity;loss of function;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Measures;Mediating;Mesenchymal;mesenchymal stromal cell;Metabolic;Metals;Mission;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;neutrophil;novel;novel therapeutics;old mice;osteoblast differentiation;osteogenic;osteoimmunology;overexpression;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;particle;pathogen;Pathogenicity;Pathologic;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Physiology;Population;preclinical study;prevent;pro-aging;Process;programs;Public Health;Reactive Oxygen Species;receptor;Reporting;response;Role;senescence;serine receptor;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;stem;Stromal Cell-Derived Factor 1;Stromal Cells;Tamoxifen;Testing;Transgenic Organisms;United States National Institutes of Health

PROJECT_TITLE: Efferocytosis by Bone Marrow Stromal Cells and Bone Aging


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Alcohol toxicity is a leading cause of liver disease. The long-term goal of this research project is to investigate how alcohol changes protein signaling and activity in the liver through modification of cysteine and lysine amino acid residues. We will study these processes to better understand how alcohol-associated liver disease occurs and to develop targeted therapeutic interventions to protect the liver from alcohol toxicity.

PI_NAMEs: FRITZ, KRISTOFER S (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acetylation;Alcohol abuse;Alcohol consumption;Alcohol Hepatotoxicity;alcohol misuse;Alcoholic Liver Diseases;Alcohols;aldehyde dehydrogenases;American;Amino Acids;Antioxidants;Area;Aspartate Transaminase;Automobile Driving;Basic Science;Biochemical;Biochemical Pathway;Bioinformatics;Biological Assay;Cessation of life;Chemistry;Chronic;Cirrhosis;Citric Acid Cycle;Clinical;Coenzyme A;community burden;Complex;Cysteine;Data;Data Analyses;Data Set;Deacetylase;Development;Ethanol Metabolism;Ethanol toxicity;Fatty-acid synthase;Feedback;Functional disorder;Glutathione;Glycolysis;Goals;GOT2 gene;Healthcare Systems;Hepatic;Hepatocyte;Homeostasis;Hospitalization;Inflammatory Response;innovation;Intervention;Investigation;Link;lipid metabolism;Liver;Liver diseases;liver metabolism;Lysine;Metabolic;Modeling;Modification;Morbidity - disease rate;mortality;Mus;novel;novel therapeutics;overexpression;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;peroxiredoxin;peroxiredoxin 5;Post-Translational Protein Processing;Process;Protein Acetylation;protein function;Proteins;Proteome;Proteomics;Recombinant Proteins;Research;Research Project Grants;response;Signal Transduction;Signaling Protein;SIRT1 gene;Sirtuins;Site;Source;Specificity;statistics;Sulfhydryl Compounds;System;targeted treatment;Testing;Therapeutic Intervention;Time;toxicant;TXN gene;United States;Validation;Work

PROJECT_TITLE: Alcohol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Acute Myeloid Leukemia (AML) is a blood cancer that results in the death of the majority of patients. The body's immune system, particularly T cells, may recognize and eradicate the leukemia cells but are often unable to do so due to negative signals that are generated by the leukemia. The work in this proposal will allow us to better understand how drugs that target leukemia impact the immune system, which will help develop future therapeutic strategies for this lethal disease.

PI_NAMEs: LIND, EVAN FERGUSON (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adaptive Immune System;adult leukemia;Affect;Amino Acid Motifs;Animal Model;Antibodies;Behavior;Biology;Blood;Bone Marrow;Bone Marrow Aspiration;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;cancer type;Cell Differentiation process;Cell Physiology;Cell Survival;cell transformation;cell type;Cells;Cessation of life;Chromatin;Chromatin Structure;Chronic;cytokine;Data;Development;Diagnosis;Disease;DNA Methylation;DNA Methyltransferase Inhibitor;DNA Modification Methylases;Drug Targeting;Drug usage;Epigenetic Process;epigenome;exhaust;exhaustion;experimental study;Family member;Functional disorder;Functional impairment;Future;Genetic Transcription;Genetically Engineered Mouse;Goals;Hematopoietic Neoplasms;Human;Immune;immune checkpoint;immune checkpoint blockade;immune clearance;Immune Evasion;immune function;Immune system;Immune Targeting;Immunosuppression;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;Laboratories;leukemia;Leukemic Cell;Literature;Lymphoid;Malignant Neoplasms;MEK inhibition;MEKs;Mitogen-Activated Protein Kinases;mouse model;Mutation;Myelogenous;neoplastic cell;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;precursor cell;Prognosis;programs;Proliferating;Property;protein function;Protein Methyltransferases;Publishing;rational design;Reader;response;Role;Sampling;Signal Pathway;Signal Transduction;small molecule;T cell regulation;T-Cell Depletion;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Time;transcription factor;tumor;Tumor Escape;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Pathways of Immune Evasion in Acute Myeloid Leukemia

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This is a competitive renewal application for continued support of the University of Michigan Department of Pediatrics Child Health Research Career Development Award (CHRCDA) Program entitled “Advancing Child Health through Cellular and Molecular Biology.” The U-M Child Health Research Center program trains junior pediatric-scientists under the guidance of experienced biomedical scientists in scientific methods, tools and technologies that they then apply to study diseases that afflict children and young adults. The program has been highly successful in attracting accomplished physicians into careers in academic pediatrics.

PI_NAMEs: MARTIN, DONNA M. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Advisory Committees;Agreement;career development;Cellular biology;Child Health;Childhood;Complement;design;didactic education;Disease;Education;Ensure;Evaluation;Funding;Individual;K-Series Research Career Programs;medical schools;Mentors;Michigan;Minority Recruitment;Molecular Biology;Pathogenesis;pediatric department;pediatrician scientist;Physicians;Program Reviews;programs;recruit;Research;research and development;Research Personnel;Research Training;Scientist;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Advancing Child Health Through Cellular and Molecular Biology


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative: A central question in biology is to understand how the naive genome in the early embryo progressively undergoes a series of modifications to control gene expression in “time and space” such that proper cellular differentiation programs are correctly implemented. We recently investigated embryonic germ layer formation, the earliest cell fate determination process and demonstrated that Foxh1 and its associated transcription factors functions at the top of a hierarchy of interactions by marking developmental genes for activation beginning with the onset of zygotic gene expression. Here, we propose to tease out the interactions between maternal transcription factors and chromatin and uncover how the genome of embryos undergoes major structural changes as they proceed from pluripotent to differentiated cell states.

PI_NAMEs: CHO, KEN W.Y. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Area;Binding;Biology;Cell Differentiation process;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Code;combinatorial;Complex;Development;Developmental Gene;DNA Sequence;Embryo;Enhancers;Ensure;Epigenetic Process;Event;FOXH1 gene;Gene Activation;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Genomic approach;Germ Layers;Goals;histone modification;imaging approach;in vivo;insight;Modification;molecular assembly/self assembly;Nucleosomes;Phase;pluripotency;Process;programs;Proteins;Rana;Regimen;Research;Role;Series;Shapes;Site;System;Time;transcription factor;transcriptome;Work;zygote

PROJECT_TITLE: Maternal transcription factors shaping early embryonic chromatin landscape

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Winship Cancer Institute of Emory University has made outstanding contributions to the NCTN in multiple ways, including providing scientific leadership, service to the network groups, robust patient enrollment, participation in important NCI steering committees and task forces, and providing mentorship to the next generation of researchers. As Georgia's only comprehensive cancer center, Winship is well positioned to continue its major contributions to the NCTN in every possible manner.

PI_NAMEs: JANI, ASHESH ;LOWE, MICHAEL ;SABA, NABIL F (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adolescent;Advisory Committees;African ancestry;American College of Radiology Imaging Network;Award;base;Cancer Center Support Grant;cancer imaging;cancer prevention;career;career development;Caring;Cause of Death;Child;Clinical Trials;Clinical Trials Network;Community Clinical Oncology Program;Comprehensive Cancer Center;Dedications;design;Diagnosis;Eastern Cooperative Oncology Group;Education;Enrollment;Faculty;Fellowship;Funding;Goals;health disparity;Hospitals;Immunotherapy;innovation;Institution;Investments;K-Series Research Career Programs;Lead;Leadership;Lung;Malignant Neoplasms;Measures;Medical center;member;Mentors;Mentorship;Minority Enrollment;minority patient;National Clinical Trials Network;next generation;novel;Oncology;Operative Surgical Procedures;participant enrollment;patient population;Patients;Pediatric Oncology Group;Play;Positioning Attribute;Precision medicine trial;programs;Radiation Oncology;Research;Research Activity;Research Personnel;Resource Sharing;Role;Services;Site;success;targeted treatment;Therapeutic;Underrepresented Minority;underserved minority;Universities;working group

PROJECT_TITLE: Winship National Clinical Trials Network Lead Academic Participating Site


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Natural Products;Patient Safety;Substance Misuse;Therapeutic Cannabinoid Research

PHR: Project Narrative I will learn how cannabis (specifically CBD) products have been researched and regulated and how to apply natural language processing (NLP). I will field a detailed survey with open- and close-ended questions to (1) Describe the characteristics of CBD users, (2) Characterize CBD use as a substitute or adjunct to other medications, and (3) Characterize self-reported CBD- related adverse events. I will apply modern text analysis approaches vested natural language processing to analyze responses to open-ended questions, discovering responses that cannot be anticipated based on current understanding or may be missed by theoretical expectations.

PI_NAMEs: LEAS, ERIC  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adult;Adverse event;Awareness;Big Data;Cannabidiol;Cannabinoids;Cannabis;Cannabis policy;Characteristics;childhood epilepsy;Code;Consumption;Data;Data Sources;Dose;Drug Interactions;Drug usage;Epidemiology;Epidiolex;Ethics;Event;expectation;Farm;FDA approved;Frequencies;Future;Goals;Growth;Hand;Health;Hemp;Individual;innovation;Knowledge;Label;Language;Lead;Learning;Legal;Life Style;Manufacturer;Manuscripts;Marijuana;Medical;Medical Dictionaries;Medical Records;Medicine;Methodology;Methods;Modeling;Modernization;National Institute of Drug Abuse;Natural Language Processing;news;Oral;Patient Self-Report;Peer Review;Pharmaceutical Preparations;Plants;Policies;Population;population based;population health;Prevalence;Production;Publications;Reporting;Research;Research Personnel;Respondent;response;Risk;Sales;Sampling;Severities;side effect;skills;Smoking;Standardization;substance use;Surveys;symposium;System;Techniques;Text;Therapeutic;Time;tobacco regulatory science;Training;Training Activity;United States;US State;vaping;Writing

PROJECT_TITLE: Characterizing the Epidemiology of Cannabidiol (CBD) Use Among US adults

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Myelodysplastic syndromes (MDS) are myeloid neoplasms with dismal prognosis, frequent progression to acute myeloid leukemia (AML) and no effective treatment. The goal of this proposal is to investigate G⍺s, the alpha subunit of the stimulatory G protein, as a therapeutic target for MDS with splicing factor mutations and identify opportunities for therapeutic interventions that inhibit its activation or downstream signaling. This work can establish a new therapeutic target and can lead to novel therapies that can transform the treatment of MDS, AML and possibly other cancers.

PI_NAMEs: PAPAPETROU, EIRINI  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Apoptosis;Biochemical;Biochemical Genetics;Biological Assay;Bone Marrow;Cell Physiology;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cyclic Peptides;Data;Dependence;Development;Disease;drug development;Dysmyelopoietic Syndromes;effective therapy;FLT3 gene;Frequencies;Future;G-Protein-Coupled Receptors;Gases;Gene Mutation;Genes;Genetic;genetic approach;Genetic Transcription;GNAS gene;Goals;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Hematopoietic;Hematopoietic stem cells;Human;human induced pluripotent stem cells;In Vitro;induced pluripotent stem cell;Inflammatory;inhibitor;Knock-out;leukemic transformation;Malignant Neoplasms;Mediating;mRNA Precursor;mutant;Mutate;Mutation;Myeloproliferative disease;new therapeutic target;novel;novel therapeutics;Oncogenic;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Population Genetics;Process;Production;Prognosis;programs;Protein Array;Protein Isoforms;research clinical testing;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Secondary acute myeloid leukemia;Secondary to;Signal Pathway;Signal Transduction;Signaling Molecule;Somatic Mutation;Spliced Genes;SRSF2 gene;stem cell model;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Banks;Transcript;transcriptome sequencing;transcriptomics;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms and targeting of aberrant Gas activation in myeloid neoplasms

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative  Frontonasal dysplasia (FND) are congenital craniofacial disorders that profoundly impact the form and function of the face, nose, and mouth. FND patients require multiple corrective surgeries and often suffer life-long impairment. Using novel mouse and human pluripotent stem cell models, this project will uncover the underlying molecular genetic basis and lead to significant improvement in molecular diagnosis, genetic counseling, and treatment of patients with FND and related craniofacial disorders.

PI_NAMEs: JIANG, RULANG  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;Animal Model;Anterior;autosome;Caring;Cell Differentiation process;Cell Line;Cephalic;Chromatin;chromosome conformation capture;Chromosomes;Clinical Management;Code;Complex;Congenital Abnormality;craniofacial;craniofacial development;craniofacial disorder;cranium;CRISPR/Cas technology;Data;Development;developmental disease;Diagnosis;Disease;disease model;Distal;DNA Binding;Ectopic Expression;Embryonic Development;Enhancers;Etiology;Exhibits;Face;Family;Frontonasal dysplasia;Gene Deletion;Gene Expression;Gene Structure;Generations;Genes;Genetic Counseling;genome editing;Genomics;Heterozygote;Homeobox;Homozygote;Human Cell Line;human pluripotent stem cell;Impairment;improved;insight;irradiation;Kidney;Link;Lip structure;loss of function;Mediating;member;Mesenchyme;microdeletion;midfacial hypoplasia;Molecular;Molecular Diagnosis;Molecular Genetics;mouse model;Mus;mutant mouse model;Neonatal;Neural Crest Cell;Nose;novel;Operative Surgical Procedures;Oral cavity;Orbital separation excessive;orofacial;Palate;paralogous gene;Pathogenesis;Pathogenicity;Patients;Phenotype;Pluripotent Stem Cells;Positioning Attribute;promoter;Proteins;Reproducibility;Resources;Sequence Deletion;Site;stem cell model;Structure;Syndrome;Tail;Testing;transcription factor;Variant;vertebrate genome

PROJECT_TITLE: Molecular Basis of SIX2-related Frontonasal Dysplasia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: The picornaviruses are a large family of viruses that cause a range of human diseases, including paralysis, hand foot and mouth disease in young children, and many cases of the common cold. These viruses replicate using an RNA-dependent RNA polymerase enzyme that is very error prone, resulting in viruses that can rapidly adapt to different cell types or become resistant to antiviral drugs. The primary focus of this project is to gain an atomic level structural understanding of the basic protein-protein and protein-RNA interactions that control virus replication with a secondary focus to understand why the viral polymerase is so error prone and use this information to interfere with its normal function in ways that could lead to new vaccines or antiviral drugs.

PI_NAMEs: PEERSEN, OLVE BREIEN (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Active Sites;Acute;Address;Anti-viral Agents;Attenuated;Binding;Biochemical;Biochemistry;biophysical techniques;cell type;Child;Collaborations;Common Cold;Complex;Coronavirus;cost;Coxsackie Viruses;Data;design;Disease;DNA-Directed RNA Polymerase;Elements;Enterovirus 68;Enzymes;Event;Evolution;Family;Family Picornaviridae;Foot Diseases;Frequencies;Genetic Recombination;Genome;genomic RNA;Goals;Growth;Hand;Hand's disease;Heart Diseases;human disease;Human poliovirus;Life Cycle Stages;Maintenance;Maps;Mediating;member;Membrane;Molecular;Mouth Diseases;Mus;mutation screening;novel;novel vaccines;Paralysed;Pathway interactions;Peptide Hydrolases;Poliomyelitis;Polymerase;Polyproteins;Positioning Attribute;Process;Protease Domain;Protein Engineering;Protein Precursors;protein protein interaction;Proteins;Proteolytic Processing;Reaction;Replication-Associated Process;Research Project Grants;Rhinovirus;RNA;RNA Binding;RNA chemical synthesis;RNA replication;RNA Sequences;RNA Viruses;RNA-Directed RNA Polymerase;RNA-Protein Interaction;Role;Site;Specificity;stem;structural biology;Structure;Surface;Translations;Viral;Viral Drug Resistance;Viral Genome;viral RNA;Virion;Virus;Virus Assembly;Virus Replication;Work

PROJECT_TITLE: Assembly of Picornaviral Replication Complexes

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Liver Disease;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE The complex web of signals that arise from malaria parasite development within a host hepatocyte is highly medically relevant, as malaria kills more than half a million people annually. This proposal seeks to understand how malaria parasites overcome host cell death defenses, and how their inability to do so impacts subsequent immunity to infection.

PI_NAMEs: KAUSHANSKY, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Animals;Antigen-Presenting Cells;Antigens;Apoptosis;Apoptotic;Biological;Blood;CD8-Positive T-Lymphocytes;Cell Death;cell killing;Cell Survival;cell type;Cells;Cessation of life;Characteristics;Collection;comparative;Complex;CRISPR screen;Culicidae;cytokine;Data;design,build,test;Development;Disease;Dissection;Environment;Equilibrium;Erythrocytes;experimental study;Genetic;Genetic Transcription;genome-wide;Growth and Development function;Hepatocyte;Host Defense;Human;Immune;Immune response;Immunity;Immunologic Stimulation;Immunologics;In Situ;in vivo;Individual;Infection;Inflammatory;insight;Integration Host Factors;Internet;Intervention;Invaded;Investigation;Knock-out;Lipid Peroxidation;Lipid Peroxides;Liver;liver infection;LoxP-flanked allele;Macrophage;Malaria;malaria infection;Mediating;Mediator;Medical;migration;Mitochondria;Molecular;Mus;Nature;Outcome;Parasites;Parasitic infection;pathogen;Pathway interactions;Persons;Plasmodium;prevent;Process;Proteomics;recruit;Research;Resources;response;Robot;Role;Signal Transduction;Site;small molecule;Sterility;Stimulus;Stream;System;T cell response;T-Cell Development;T-Lymphocyte;Technology;Testing;Tissues;tool;transcriptomics;transmission process;Vaccination;Vaccines;whole genome

PROJECT_TITLE: Perturbations of host cell signaling by a complex hepatotropic pathogen

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]