NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Risky alcohol use is one of the most common risk factors for surgical complications among elective surgical patients. This study will develop an automated computable phenotype to classify risky alcohol use prior to surgery using electronic health record data, and longitudinally evaluate the association between risky alcohol use and adverse surgical outcomes. Accurate and early identification of patients is needed to implement critical pre-operative alcohol interventions.

PI_NAMEs: FERNANDEZ, ANNE CHRISTIE (contact);VYDISWARAN, VG VINOD

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Accounting;Address;Adverse event;Agreement;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol risk;alcohol screening;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Algorithms;Biological Markers;care episode;Categories;Classification;Clinic;Clinical;clinical application;Clinical Data;Clinical Research;Code;cohort;Collaborations;Communities;Community Health;computable phenotypes;Computer Assisted;computerized tools;Consumption;cost;Data;Data Collection;Data Element;Data Set;direct application;early alcohol use;Early identification;Electronic Health Record;Electronics;Evaluation;Event;experience;Foundations;Funding;Future;future implementation;Guidelines;Health;health care service;Health Expenditures;Health Services Accessibility;high risk;hospital readmission;Hospitals;implementation research;improved;Individual;innovation;International Classification of Disease Codes;Intervention;Intervention Studies;knowledgebase;Label;Length of Stay;Link;longitudinal analysis;Machine Learning;machine learning method;Measures;Methodology;Methods;mortality;Natural Language Processing;novel;Operative Surgical Procedures;Opioid;Outcome;Outcome Study;Patients;Pharmaceutical Preparations;Phase;Phenotype;phosphatidylethanol;Postoperative Period;Precision Health;prevent;prospective;Research;Research Support;Risk;Risk Factors;Severities;Structure;structured data;surgery outcome;Surgical complication;surgical risk;Testing;Time;tool;Training;unstructured data;Work

PROJECT_TITLE: Leveraging electronic health records to identify risky alcohol use prior to surgery


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE PTEN hamartoma tumor syndrome (PHTS) describes individuals with germline PTEN mutations, and is characterized by high risks of breast, thyroid and other cancers, and puzzlingly, is a common cause of autism spectrum disorder (ASD) in a subset of PHTS; however, it is not known why some develop cancer and others ASD. If this project is successful, then we will identify biological factors that affect a PHTS individual’s probability of developing ASD, cancer, or both conditions together, and to build methods that clinicians can adopt at the point-of-care to inform patients of their individual risks. The proposed research is relevant to public health because ASD, increasing in prevalence annually, represents a major medical and societal challenge; despite significant advances in diagnosis and early interventions, precise determinants of etiology and comorbidities such as cancer remain unresolved.

PI_NAMEs: FRAZIER, THOMAS WILLIAM;NI, YING  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Accounting;Adopted;Adoption;Adult;Affect;autism biomarker;autism spectrum disorder;Biochemical Pathway;Biological;Biological Factors;Biological Markers;Biology;Breast;cancer predisposition;cancer prevention;cancer risk;candidate identification;Cells;Child;Clinical;clinical practice;clinical translation;Code;cohort;comorbidity;Computer software;Copy Number Polymorphism;Data;Derivation procedure;Development;Developmental Delay Disorders;Diagnosis;Disease;disorder risk;Disparate;Early Intervention;enzyme pathway;Etiology;evidence base;Family;General Population;Genetic;Genome;genome sequencing;genome-wide;genomic biomarker;Genomics;Genotype;Germ Lines;Growth;high risk;High-Risk Cancer;improved outcome;Individual;individual patient;individuals with autism spectrum disorder;Inherited;innovation;Intervention;Knowledge;Lead;Learning;lifetime risk;Longitudinal Studies;lymphoblastoid cell line;Macrocephaly;Malignant Neoplasms;Measurable;Medical;Medicine;Mental Health;Metabolic;metabolic phenotype;metabolome;metabolomics;Methods;model development;model of autism spectrum disorder;Modeling;multimodality;Mutate;Mutation;Mutation Detection;National Institute of Child Health and Human Development;Neurodevelopmental Disorder;Nomograms;Observational epidemiology;Outcome;Patients;Persons;Phenotype;phenotypic biomarker;Plasma;point of care;polygenic risk score;Population;predictive marker;predictive modeling;Prevalence;prevent;Prevention;Probability;prospective;PTEN autism spectrum disorder;PTEN gene;PTEN Hamartoma Tumor Syndrome;Public Health;Reaction;Research;Risk;Risk Estimate;Risk Management;risk stratification;Sampling;Science;segregation;Series;Strategic Planning;Syndrome;System;Testing;Therapeutic;Thyroid Gland;translational approach;Tumor Suppressor Genes;Untranslated RNA;Variant;whole genome;young adult

PROJECT_TITLE: Modeling Autism and Comorbid Cancer Risk in Individuals with Germline PTEN Mutations

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: Alternative splicing processes over 95% of mRNA in human beings and its dysregulation is a hallmark of various cancers and other diseases. The decision of exon selection is made in early- stage spliceosome assembly, which involves the key steps of RNA binding of the protein SRSF1, and recruitment of proteins U1-70K and U2AF-35. The overall goal of this proposal is to elucidate the structural mechanism by which the SRSF1 coordinates RNA binding, protein interaction and phase separation in early-stage spliceosome assembly.

PI_NAMEs: ZHANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affinity;Alternative Splicing;Binding;biophysical techniques;Complex;Disease;Enhancers;Equilibrium;Event;Exons;Family;Genes;Goals;Human;human disease;Knowledge;Length;Malignant Neoplasms;Mediating;member;Messenger RNA;Methods;Modeling;molecular dynamics;Nuclear;Pattern;Phase;Phosphorylation;Phosphorylation Inhibition;preference;Process;Protein Isoforms;Proteins;prototype;recruit;Repetitive Sequence;Ribonucleoproteins;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Site;Solubility;Specificity;Spliceosome Assembly Pathway;success;therapy development

PROJECT_TITLE: The central roles of SRSF1 in early-stage spliceosome assembly

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BURNABY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SIMON FRASER UNIVERSITY

ORG_STATE: BC

ORG_ZIPCODE: V5A 1S6

PHR: PROJECT NARRATIVE One of the major challenges in the HIV vaccine field continues to be the development of one or more formulations that can elicit antibodies to conserved sites on the spike protein. Our interest is in a reasonably conserved cluster of sugar molecules on the HIV spike. Antibodies to these sugar molecules are not elicited readily by conventional approaches, possibly because these sugars are imparted by the cell and therefore considered ‘self’ molecules. We are investigating whether synthetic sugars molecules resembling the target sugars can ‘trick’ the immune system into producing antibodies that will bind the similar-looking sugar molecules on the HIV spike surface. In this renewal application, we propose to continue our investigations on this front. In the short term, we expect our findings to provide insight into immunological discrimination between self- and non-self-sugar molecules and how the application of adjuvants might promote such recognition/differentiation.

PI_NAMEs: PANTOPHLET, RALPH ALPHONSO (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Address;Adjuvant;Affinity;analog;Antibodies;Antibody Response;Antibody titer measurement;Antigen Mimicry;arm;Avidity;B-Lymphocytes;Bacterial Polysaccharides;Binding;Carrier Proteins;Cells;Clinical;cross reacting material 197;cross reactivity;design;Development;Discrimination;Epitopes;Family;Formulation;Frequencies;Future;Germ Lines;Glycoconjugates;glycomimetics;Glycosides;glycosylation;HIV;HIV Envelope Protein gp120;HIV vaccine;HIV-1;Human;Immune system;Immune Tolerance;Immunization;Immunize;immunogenicity;Immunologics;Individual;Infection;insight;interest;Investigation;Lead;Lipid A;Mannose;mimetics;mimicry;mouse model;Mus;Nature;neutralizing antibody;Oligosaccharides;Polysaccharides;preclinical study;Progress Reports;Proteins;Publishing;Rat Transgene;receptor;Recombinants;Reporting;Research;Site;Specificity;Structure;sugar;Surface;Time;TLR4 gene;TLR7 gene;Transgenic Mice;Vaccine Design;Work

PROJECT_TITLE: Adjuvant, mimicry and booster requirements for shepherding the development of neutralizing antibodies to the high-mannose patch on HIV-1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: JACKSON

ORG_NAME: MISSISSIPPI STATE DEPARTMENT OF AGRICULTURE AND COMMERCE

ORG_STATE: MS

PHR: Project Narrative This Mississippi Department of Agriculture and Commerce’s (MDAC) project entitled Maintaining the Produce Safety Rule in Mississippi to Enhance Safety in Growing, Harvesting, Packing, and Storing Fresh Fruits and Vegetables is intended to sustain the established produce safety program that encourages the safe production of fruits and vegetables and promotes understanding and compliance with FDA’s Produce Safety Rule. To sustain the established produce safety program, MDAC will:  • Continue to assess and identify the produce landscape and available resources in Mississippi  • Continue to leverage current resources and invest in the infrastructure needed for  appropriate outreach, education, and technical assistance to produce growers  • Continue the development of the established inventory of farms in Mississippi  • Promulgate regulations based on the Mississippi produce safety law  • Continue and sustain the established compliance program for the Produce Safety Rule These five goals will greatly advance a national Integrated Food Safety System (IFSS) and effectively fulfill the requirements of the Food Safety Modernization Act (FSMA).

PI_NAMEs: THORNTON, BRANDON D (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C Maintaining the Produce Safety Rule in Mississippi to Enhance Safety in Growing, Harvesting, Packing, and Storing Fresh Fruits & Vegetables MDAC


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose a Center for Research on Complex Generics that will support the Food and Drug Administration's (FDA's) efforts to enhance research collaborations with the generic industry, to further the FDA's mission of increasing access to safe and effective generic drugs. The Center for Research on Complex Generics will increase access to safe and effective generic drugs through collaborative research, training, and exchange. Activities leverage faculty expertise in formulation and evaluation of complex drugs, as well as exceptional laboratory and training space, to move the development and assessment of complex generics forward.

PI_NAMEs: POLLI, JAMES E (contact);SCHWENDEMAN, ANNA

PROGRAM_OFFICER_NAME: RANEY, SAMEERSINGH

PROJECT_TITLE: Center for Research on Complex Generics


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

ORG_STATE: UT

PHR: Project Narrative Community-acquired pneumonia is the most common serious infection among adults in the United States, but diagnosis and treatment decisions by clinicians fall short of consistent, guideline-adherent care, thereby threatening patient safety. We aim to disseminate a validated real-time, electronic clinical decision support tool for pneumonia and optimize its interoperability, scalability, and usability by developing a SMART on Fast Healthcare Interoperability Resources version that places patients and clinicians at the center. We will then deploy the tool to two distinct emergency departments at Vanderbilt, study the implementation process, and evaluate the impact on patient outcomes.

PI_NAMEs: DEAN, NATHAN C (contact);LANGLOTZ, CURTIS P;WARD, MICHAEL J.

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Development of SMART on FHIR interoperable clinical decision support for emergency department patients with pneumonia and pilot deployment into novel Epic electronic health record environments

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: DES MOINES

ORG_NAME: IOWA DEPT AGRICULTURE/LAND STEWARDSHIP

ORG_STATE: IA

PHR: Project Narrative Our dual focus will be to maintain our compliance with the Animal Feed Regulatory Program Standards (AFRPS) and to improve our processes under the AFRPS standards and to implement the PCAF regulations at IDALS. This will require reviewing code to, developing a training program, and developing an Out Reach program to help producers to understand their responsibilities under the new regulation.

PI_NAMEs: GAMBLE, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: CLARK, JACOB

PROJECT_TITLE: IDALS/FDA AFRPS Maintenance with PC Regulatory Activities


ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Type 2 diabetes (T2D) in pregnancy affects over 100,000 individuals annually in the U.S., of which >50% are enrolled in Medicaid, and most enter prenatal care with suboptimal glycemic control. We propose “ACHIEVE: Successfully achieving and maintaining euglycemia during pregnancy for type 2 diabetes through technology and coaching,” a multi-component intervention that includes a mobile health (mHealth) application, provider dashboard, continuous glucose monitoring (CGM), and team-based coaching for medical and social needs. ACHIEVE empowers Medicaid-enrolled pregnant individuals with T2D and their healthcare providers to achieve and maintain glycemic control, improve access to care, and provide patient education and support.

PI_NAMEs: FAREED, NALEEF  (contact);JOSEPH, JOSHUA J;VENKATESH, KARTIK KAILAS

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT


ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Cells require their actin cytoskeleton to divide, move, and communicate with their environment. This project will reveal novel mechanisms of how actin monomers, the basic subunit the actin cytoskeleton, control the assembly and organization of actin structures in the cell. Deciphering these fundamental mechanisms could explain why defects in monomer regulation are associated with human diseases such as neurodegeneration, inflammatory disorders, cardiac disease and cancer.

PI_NAMEs: VITRIOL, ERIC A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Back;Behavior;Biochemical;Biochemistry;Biology;cell behavior;cell growth regulation;Cell Physiology;Cells;cellular imaging;Communication;Complex;Computer Models;Cytoskeleton;Defect;Disease;Environment;experimental study;Filament;Geometry;Heart Diseases;human disease;Image Analysis;Inflammatory;innovation;Knowledge;Malignant Neoplasms;monomer;Nerve Degeneration;novel;polymerization;Polymers;Proteins;quantitative imaging;Regulation;Role;Structure;Subgroup;superresolution imaging;tool;Work

PROJECT_TITLE: Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin Dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LAS VEGAS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE The widespread use of organophosphate esters (OPEs) as flame retardants has resulted in ubiquitous exposure, which have been observed to impact lipid levels, disrupt metabolic function, and impair glucose tolerance in toxicological studies, supporting OPEs as obesogenic and metabolism-disrupting chemicals. While some epidemiological studies have reported that OPEs are associated with lipid accumulation, specifically increased odds of being overweight and obese as well as higher waist circumference, body mass index (BMI), total cholesterol, and triglycerides, no study has examined the relationship between early life OPE exposures and adiposity and cardiometabolic health in adolescence using a prospective study design. We propose to utilize the Health Outcomes and Measures of the Environment (HOME) Study to examine whether early life OPE exposures, from gestation to adolescence, are associated with adiposity and cardiometabolic health outcomes in adolescence at 12 years using repeated measurements of OPEs to identify periods of susceptibility, while also using advanced statistical methods to account for complex OPE mixtures.

PI_NAMEs: VUONG, ANN  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: 12 year old;Adipocytes;adiponectin;Adolescence;Adult;Affect;Age;Androgen Receptor;Biological;Biological Markers;Birth;Blood Pressure;Body Burden;Body fat;Body mass index;C-reactive protein;Canada;cardiometabolism;Chemicals;Child;Cholesterol;Chronic;cohort;Complex;Data;Development;Diet;Dyslipidemias;early adolescence;early life exposure;Endocrine Disruptors;Environment;environmental chemical;Environmental Exposure;Environmental Policy;epidemiology study;Esters;Estrogen Receptors;Exposure to;Family;Fasting;fasting glucose;Fatty acid glycerol esters;Flame Retardants;General Population;Genetic;Glucose;Glycoproteins;Gonadal Steroid Hormones;Growth;Health;Health Resources;Heart Diseases;high risk;Hip region structure;Homeostasis;Hormones;Human;Hypertension;impaired glucose tolerance;indexing;Individual;Infant;Inflammation;inorganic phosphate;Insulin;Insulin Resistance;Interleukin-6;Joints;Leptin;Life;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Lipoproteins;Longitudinal Studies;Measurement;Measures;Metabolic;metabolic profile;Metabolic syndrome;Metabolism;Modeling;Modernization;Molecular Weight;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;obesity development;obesity in children;obesity risk;obesogen;obesogenic;Organophosphates;Outcome;Outcome Measure;Overweight;Oxidative Stress Induction;particle;Pathogenesis;Pathway interactions;Perinatal;Peroxisome Proliferator-Activated Receptors;Phase;Physical activity;Plasticizers;Play;Policy Making;pollutant;polybrominated diphenyl ether;postnatal;postnatal period;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Prevalence;prospective;Prospective Studies;Public Health;Reporting;Research;Research Design;Risk Factors;Rodent;Role;Serum;Statistical Methods;Thermogenesis;Thyroid Hormones;Time;Tissues;TNF gene;Toxicology;trait;transcription factor;Triglycerides;tris(2-carboxyethyl)phosphine;United States;urinary;waist circumference

PROJECT_TITLE: Early life organophosphate ester (OPE) exposures and adiposity and cardiometabolic health during adolescence

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The nickel-based cross-coupling reactions evaluated in this proposal utilize a terrestrially abundant metal catalyst to elaborate amide and ester functional groups prevalent in biologically derived and bioactive molecules. This project is relevant to the public health mission of the NIH because it will establish the critical insights necessary to develop these transformations into the next generation of practical tools for the efficient, selective, and environmentally benign preparation of pharmaceuticals for the study and treatment of human disease.

PI_NAMEs: KENNEDY, ROSE  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: 3-Dimensional;Address;Amides;Area;Benign;Catalysis;catalyst;Computer Analysis;Coupling;Crystallography;design;Development;Environment;Esters;experience;Face;functional group;Goals;Health;Human;human disease;improved;innovation;insight;invention;Investigation;Kinetics;Ligands;Metals;Methodology;Methods;Mission;Molecular Probes;next generation;Nickel;Palladium;Pharmaceutical Preparations;Play;programs;Public Health;Reaction;Reaction Time;Research;Research Personnel;Role;small molecule;small molecule therapeutics;Source;Structure;Temperature;tool;Transition Elements;Translating;translational potential;United States National Institutes of Health

PROJECT_TITLE: Mechanistic Insights into Catalytic Acyl C-O and C-N Activation and Cross Coupling


ORG_CITY: PORTLAND

ORG_NAME: OCHIN, INC.

ORG_STATE: OR

PHR: Project Narrative Healthy People 2020 and the National Institute of Health have identified rural health disparities and the lack of research on rural health as top priorities, yet little is known about the effects of the COVID-19 pandemic on primary care utilization among rural patients. The goal of the proposed study is to advance knowledge on how the COVID-19 pandemic and subsequent wide-scale expansion of telemedicine has affected the use of primary care services and quality of preventive care among rural, low-income patients compared to those residing in urban areas. This innovative research project will help inform efforts to improve healthcare access and quality of care for low-income, rural patients.

PI_NAMEs: LARSON, ANNIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: The effect of rurality and the COVID-19 pandemic on telemedicine and preventive healthcare use

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE: In well-resourced, tertiary care emergency departments (EDs), ultrasonography or magnetic resonance imaging are typically used to diagnose appendicitis, the most common pediatric surgical emergency, in children presenting to the ED with abdominal pain. Clinicians in resource-limited settings such as community EDs, however, encounter a diagnostic dilemma in these situations: they must often choose between computed tomography (CT), which carries the risk of radiation exposure, and watchful waiting, which carries the risk of delayed diagnosis. We aim to develop and test a shared decision-making intervention that would allow ED clinicians and patients/families to make the decision about diagnostic next steps together, with the goal of optimizing resource utilization, increasing patient/family engagement, and reducing unnecessary CT scans without increasing the risk of delayed diagnosis of acute appendicitis.

PI_NAMEs: MANGUS, COURTNEY W. (contact)

PROGRAM_OFFICER_NAME: WYATT, DERRICK

PROJECT_TITLE: Development and Testing of an Intervention to Facilitate Shared Decision-Making in Pediatric Patients with Abdominal Pain Presenting to the Community Emergency Department Setting


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative.  The central goal of our project is to better understand the role of mobile genetic elements in human cancers. Because new mobile element insertions (MEIs) can initiate human cancers, our work is relevant to the mission of the National Cancer Institute.

PI_NAMEs: DEVINE, SCOTT E (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Adult;Brain;Colorectal;Complement;Data;Data Collection;DNA Insertion Elements;Elements;Epithelium;Genome;Germ Lines;Goals;Human;human disease;Human Genome;human tissue;L1 Elements;Length;Lung;Malignant Neoplasms;Mediating;Methods;Methylation;Mission;Mobile Genetic Elements;Mutagenesis;Mutagens;Mutate;National Cancer Institute;Normal tissue morphology;novel;offspring;Oncogenes;Pancreas;Regulation;Reporting;Repression;Resources;Retrotransposon;Role;Sampling;Somatic Cell;Source;Suggestion;The Cancer Genome Atlas;Tissues;tumor;Tumor Suppressor Genes;Tumor Tissue;tumorigenesis;Work

PROJECT_TITLE: Mobile element mutagenesis as a driver of human cancers

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: NORMAN

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative: Patients suffering from a traumatic injury, autoimmune reaction, or severe viral infection often experience a sense of ‘brain fog’, which is the manifestation of chronic inflammation and acute damage within the brain tissue. We have identified two mechanisms through which innate immune cell activation drives this acute brain damage; infiltration of activated white blood cells from bloodstream circulation and chronic inflammation of brain- resident microglia. We will use drug delivery systems to activate innate immune cells within target tissues (i.e. blood, brain) in a controlled manner, both to uncover mechanistic insights into inflammation-induced brain injury and the lay groundwork for new anti-inflammatory therapeutics.

PI_NAMEs: CLEGG, JOHN R (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Acute Brain Injuries;Address;Anatomy;Anti-Inflammatory Agents;Autoimmune;Autoimmune Diseases;Award;Basic Science;Biodistribution;biomaterial compatibility;Blood;Blood Circulation;Brain;brain fog;Brain Injuries;brain parenchyma;brain tissue;Cells;Central Nervous System;Chronic;Circulation;crosslink;cytokine;Development;Disease;Drug Delivery Systems;Drug usage;Encapsulated;Encephalitis;experience;Exposure to;Hydrogels;Immune;immune activation;immune cell infiltrate;immunoregulation;Implant;implantation;Infiltration;Inflammation;Inflammatory;Injectable;Injections;insight;interdisciplinary collaboration;Interferon Type II;Interleukin-10;invention;Investments;Leukocytes;Macrophage;Mentors;Microglia;monocyte;monomer;mouse model;Mus;Myeloid Cells;NanoGel;Neurologic Deficit;neutrophil;Neutrophil Activation;Patients;Peripheral;Phenotype;Process;Prophylactic treatment;Proteins;Reaction;Resources;Role;Scientist;targeted treatment;Technology;Therapeutic;Time;Tissues;Toxin;Training;Traumatic injury;Variant;Virus Diseases

PROJECT_TITLE: Enabled by drug delivery: Studying the role of brain-resident and infiltrating myeloid cell phenotype in brain damage associated with inflammatory disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lymphatic Research;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Inflammation in the brain results in the accumulation of excess waste, fluid, and immune cells which require mechanisms of drainage and coordination with the peripheral immune system. Failure to do so may result in the exacerbation of a variety of brain diseases like Alzheimer’s, traumatic brain injury, Parkinson’s, glioblastoma, multiple sclerosis and stroke. Our lab discovered that meningeal lymphatic vessels at the cribriform plate near the front of the brain are highly dynamic regulators of neuroinflammation and we seek to understand if local crosstalk between these lymphatic vessels and migratory dendritic cells controls disease related immune response in the brain. Pharmacological manipulation of the cross-talk between dendritic cells and cribriform lymphatic endothelial cells may have potential therapeutic value for diseases of the central nervous system.

PI_NAMEs: FABRY, ZSUZSANNA  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adhesions;Alzheimer's Disease;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Binding;Brain;Brain Diseases;Brain Drains;brain parenchyma;Cell Communication;cell motility;cell type;Cells;Central Nervous System;Central Nervous System Diseases;CNS autoimmunity;Communication;confocal imaging;cribriform plate;Cues;Data;Dendritic Cell Pathway;Dendritic Cells;Disease;Disease Progression;disorder control;Drainage procedure;draining lymph node;Endothelial Cells;Failure;Flow Cytometry;Fluid Balance;Foundations;Gene Expression;Genomics;Glioblastoma;Growth;Homeostasis;Immune;Immune response;Immune system;Immunity;Immunologics;immunoregulation;In Situ;in vivo;Infiltration;Inflammation;Inflammatory;Intervention;Intravenous;ITGAX gene;Label;Leukocytes;Liquid substance;Location;Longitudinal Studies;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vessel;Lymphoid;Maps;Measurable;Measures;Meningeal;Meningeal lymphatic system;migration;Multiple Sclerosis;Mus;Nature;Neuroimmune;neuroinflammation;neuropathology;Parkinson Disease;Pathway interactions;Peripheral;pharmacologic;Population;Positioning Attribute;prevent;programmed cell death ligand 1;Publishing;receptor;recruit;Regulation;Resolution;Role;Route;single-cell RNA sequencing;Stains;Stroke;Structure of choroid plexus;Subarachnoid Space;Synapses;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;timeline;Tissues;trafficking;Traumatic Brain Injury;Vascular Endothelial Growth Factor C;Visualization;wasting

PROJECT_TITLE: Regulation of Neuroinflammation by Meningeal Lymphatics

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Cancer vaccines are promising strategy to stimulate robust and durable immune responses against tumors, but they have yielded only modest clinical success due to several critical immunological barriers. This proposal aims to address these challenges through the development of a new cancer vaccine platform that targets antigens arising from patient-specific mutations. If successful, this approach to bolstering antitumor immunity has potential to increase the number of patients that benefit from cancer immunotherapy.

PI_NAMEs: WILSON, JOHN TANNER (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: adaptive immunity;Address;Adjuvant;Agonist;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Artificial nanoparticles;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cell Maturation;Cellular Immunity;Characteristics;Charge;Circulation;Clinical;clinical translation;Clinical Treatment;combinatorial;cytotoxic;cytotoxic CD8 T cells;Data;Dendritic Cells;design;Development;Dinucleoside Phosphates;Drug Delivery Systems;Endosomes;Engineering;fabrication;Formulation;Goals;Homing;Hydrophobicity;immune checkpoint blockade;Immune response;immunoengineering;immunogenicity;Immunologics;Immunosuppression;Immunotherapy;improved;improved outcome;Infiltration;Inflammatory Response;insight;Interferon Type I;Investigation;Length;Libraries;Link;Lipids;lipophilicity;lymph nodes;Malignant Neoplasms;manufacture;Mediating;Minority;Modeling;Morphology;multidisciplinary;Mutation;Myeloid Cells;N-terminal;nano;nanoparticle;nanopolymer;nanoscale;Natural Immunity;neoantigen vaccine;neoantigens;novel;novel strategies;novel therapeutics;particle;Patients;Peptides;Periodicity;personalized cancer vaccines;personalized immunotherapy;pharmacologic;Pharmacologic Substance;Polymers;Proliferating;Property;protein aminoacid sequence;Publishing;Readiness;recruit;Regimen;Research;Resistance;response;Science;Shapes;Signal Transduction;Solid Neoplasm;Stimulator of Interferon Genes;success;synchronous delivery;synergism;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;therapeutic vaccine;therapy outcome;TLR4 gene;treatment response;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Vaccination;Vaccine Adjuvant;vaccine delivery;vaccine efficacy;vaccine platform;Vaccine Therapy;Vaccines;Vesicle;virtual

PROJECT_TITLE: Engineered Vaccines for Neoantigen Targeted Cancer Immunotherapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: BICAN's Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) is designed to provide effective coordination benefits to the awardee network, the NIH, and the scientific community. Advancing the ambitious BICAN goals requires CUBIE to anticipate and address potential challenges in coordinating time-sensitive management activities, mitigating data complexity and tool scalability, and supporting diverse service needs. Our CUBIE coordination and outreach team is highly experienced in leading large consortia projects at national scale, unique in bringing a set of diverse perspectives, and well-positioned to advance the overarching goals of BICAN.

PI_NAMEs: XU, HUA ;ZHANG, GUO-QIANG  (contact);ZHENG, WENJIN JIM

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Address;Agreement;Area;Atlases;Automobile Driving;Big Data;Biometry;Brain;brain cell;brain health;BRAIN initiative;career;Cataloging;cell type;Cells;Classification;cloud based;Collaborations;Communication;Communities;computerized data processing;Data;Data Analytics;data complexity;Data Coordinating Center;data dashboard;Data Discovery;data ecosystem;data format;data modalities;data modeling;data resource;data reuse;Data Science;Data Scientist;Data Set;data standards;data tools;design;Development;digital;Discipline;Disease;Elements;Engineering;Ensure;Equipment and supply inventories;experience;FAIR principles;Feedback;gigabyte;Goals;Health;Human;Image;improved;Individual;Informatics;Institution;Ion Channel;Knowledge;knowledge base;Logistics;Machine Learning;member;Metadata;metadata standards;Microscopy;Monitor;multidisciplinary;multiplex assay;nanometer;Nervous System Disorder;neuroinformatics;Neurologic;Neurosciences;Online Systems;Ontology;outreach;petabyte;portability;Positioning Attribute;Procedures;Process;programs;RADx Radical;receptor;Research Personnel;Resource Development;Resource Sharing;Resources;Role;Secure;Services;skills;Slice;Speed;Structure;Subgroup;Synapses;synergism;System;Technology;Terminology;Testing;Time;tool;United States National Institutes of Health;usability;user-friendly;Validation;web portal;Woman;Work

PROJECT_TITLE: Engagement and outreach to achieve a FAIR data ecosystem for the BICAN


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Foodborne Illness;Prevention

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Relevance to Public Health: Growing evidence indicates that exposure to chemicals in the environmental might increase NCD risk although the mechanisms of disease initiation are not well understood. In Uganda, the estimated risk of mortality from NCDs is 22%, primarily due to cardiovascular disease and cancer among other factors. This work will assess the risk of exposure to emerging pollutants and the potential effects on mammalian metabolism to provide fundamental knowledge on how environmental insults alter biological processes and therefore inform interventions that prevent diseases and deaths through healthier environments.

PI_NAMEs: BIRUNGI, GRACE  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Adverse effects;Affect;Africa;African;albino mouse;Americas;Animals;anthropogenesis;Aromatic Polycyclic Hydrocarbons;Arsenic;Asia;Biological;Biological Markers;Biological Process;biomarker validation;candidate identification;Cardiovascular Diseases;career;career development;Case Study;Cessation of life;Chemicals;Chromatography;Chronic;Cities;Communities;Control Groups;Country;Data;Data Analyses;Developed Countries;Development;Development Plans;Diagnosis;Disease;disorder prevention;disorder risk;Doctor of Philosophy;drinking water;Ecosystem;Environment;Environmental Health;environmental toxicology;Europe;Exposure to;Fluorides;Goals;Grant;ground water;Health;Health Priorities;Heavy Metals;high risk;Histologic;Histopathology;Human;Human Resources;Industrialization;insight;Intervention;Knowledge;Leadership;Link;low and middle-income countries;Malignant Neoplasms;Mammals;Manuscripts;Mentors;Mentorship;Metabolic;metabolic profile;Metabolism;metabolome;metabolomics;Methods;Monitor;Morbidity - disease rate;mortality risk;Municipalities;Mus;National Institute of Environmental Health Sciences;Nitrates;Organ;Pathway interactions;Persons;Pesticides;Plants;pollutant;Pollution;prevent;Prognosis;Public Health;Publications;Recommendation;Reporting;Research;Research Methodology;Research Personnel;responsible research conduct;Risk;Risk Assessment;Risk Estimate;Science;Secure;Serum;skills;Source;Statistical Data Interpretation;Structure;Surface;System;Techniques;Technology;Testing;Training;Uganda;Universities;wastewater epidemiology;Water;Water Stress;Work;Writing

PROJECT_TITLE: Exposure to Mixtures of Emerging Contaminants in the Environment - Are Communities in Uganda at Health Risk?- A Case Study of Mbarara City.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


NIH_SPENDING_CATS: Aging;Bioengineering

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative  The proposed research aims to deepen our understanding of sugar-mediated protein-protein and protein-DNA non-enzymatic cross-link formation. We propose to identify the structural and dynamical molecular factors responsible for these abnormal cross-links in biological tissues. Our theoretical approach complements existing observations by accessing time and length scales invi- sible to experiments. Because cross-links are involved in a broad range of diseases, from cancer metastasis to bone and skin disorders, this project will lay the foundation for advances in disease treatment or prevention, ﬁtting NIGMS's mission statement.

PI_NAMEs: VAISSIER WELBORN, VALERIE  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;adduct;Adsorption;Aging;alpha synuclein;Alzheimer's Disease;Amines;Biological;Bone Diseases;Carbohydrates;Cardiovascular Diseases;Chronic Kidney Failure;Collagen;Computing Methodologies;crosslink;Data;Dehydration;density;Development;Diabetes Mellitus;Disease;DNA;DNA-protein crosslink;Elastin;electric field;Environment;experimental study;Foundations;Genetic Complementation Test;Glucose;glycation;Goals;Hydration status;Intervention;kinetic model;Knowledge;Length;Location;macromolecule;Mediating;Metastatic Neoplasm to the Bone;Microscopic;mineralization;Mission;Modeling;Molecular;molecular dynamics;National Institute of General Medical Sciences;Nature;Neoplasm Metastasis;nucleobase;open source;Parkinson Disease;Pathologic;Pathology;Post-Translational Protein Processing;Prevention;Process;Proteins;Protocols documentation;Proxy;quantum;Reaction;Research;Retinal Diseases;Side;Site;skin disorder;Source Code;sugar;System;theories;Therapeutic;therapeutic development;Time;Tissues;Water

PROJECT_TITLE: Elucidating the dynamical and structural molecular factors at the origin of non-enzymatic protein-protein and protein-DNA cross-links


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Based on our findings in three cardiomyocyte-restricted inducible KO models, we discovered a new GR-KLF15- BMAL1 mechanism regulating clock and metabolism in cardiomyocytes. We test here the overarching hypothesis that this cardiomyocyte-autonomous axis is triggered by specific GC timing and rescues cardiomyopathy in type-2 diabetes. We will test this paradigm by identifying 1) the circadian cue specifying this glucocorticoid effect in diabetic heart; 2) the role of the cardiomyocyte-specific BMAL1 in discriminating between beneficial versus adverse effects of chronic glucocorticoids on heart metabolism; 3) a novel provocative role for the cardiomyocyte-specific GR-KLF15 cascade to reactivate metabolic flexibility in the diabetic heart.

PI_NAMEs: QUATTROCELLI, MATTIA  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;adiponectin;Adverse effects;Antioxidants;ARFIP2 gene;ARNTL gene;Biogenesis;Biology;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Ceramidase;Ceramides;Cessation of life;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical Trials;cofactor;Corticosterone;Cues;Darkness;diabetic;diabetic cardiomyopathy;Diabetic mouse;Dimensions;Dose;Exercise;Exercise Tolerance;Failure;flexibility;Frequencies;Functional disorder;functional improvement;Genes;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Glucose;glucose metabolism;Heart;heart function;heart metabolism;Human;Impairment;improved;Insulin Resistance;insulin sensitivity;Intake;Ischemia;lifestyle intervention;Light;Link;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Mus;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;oxidation;Oxidative Stress;Pathology;Patients;Periodicity;Pharmaceutical Preparations;Pharmacology;Phase;Prednisone;programs;Pyruvate;pyruvate carrier;response;Role;safety outcomes;Signal Transduction;Specific qualifier value;Stimulus;Testing;Therapeutic Intervention;Thinness;Time;transcription factor

PROJECT_TITLE: Harnessing novel glucocorticoid biology to treat diabetic cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: Rockville

ORG_NAME: RISE THERAPEUTICS, LLC

PHR: Project Narrative Over 3 million adults in the U.S. suffer from inflammatory bowel disease (IBD). This project aims to develop clinical proof-of-concept for a novel oral immune therapy, R-3750, which delivers SlpA to the intestinal tract to reestablish gut immune homeostasis. SlpA reduces gut inflammation, reestablishes gut mucosal barrier function, induces positive maintenance of the gastrointestinal microbiome, and eliminates symptoms of experimental colitis. Based upon these properties, commercialization of R-3750 could provide an important new IBD treatment that is oral-based, safer than current drug options, and potentially lower cost.

PI_NAMEs: FANGER, GARY  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adult;Animal Model;Anti-Inflammatory Agents;Bacteria;Binding;Biological;Biological Assay;Biological Markers;Biological Response Modifier Therapy;Biopsy Specimen;Blood specimen;Bulla;C-reactive protein;C-Type Lectins;capsule;Cell Adhesion Molecules;Cell Line;Cell Physiology;Cells;Chemistry;chronic inflammatory disease;Climacteric;Clinical;clinical biomarkers;Clinical Data;clinical development;Clinical Research;clinical research site;Clinical Trials;Colitis;commensal bacteria;commercialization;Consent;Containment;cost;Crohn's disease;cytokine;data management;delivery vehicle;Dendritic Cell Pathway;Dendritic Cells;design;Development;Diagnosis;Digestive System Disorders;Disease;Documentation;Dose;Drug Compounding;Drug Delivery Systems;drug development;Engineering;Enteral;Excipients;Excretory function;Feces;first-in-human;Florida;Formulation;Future;gastrointestinal;Genetic Engineering;genetic manipulation;Goals;Growth;gut homeostasis;gut inflammation;gut microbiome;Gut Mucosa;Homeostasis;Homologous Gene;Human;Human Microbiome;Immune;Immunity;Immunologics;Immunotherapy;improved;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Infrastructure;innovation;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Investments;Label;lactic acid bacteria;Lactococcus;Lactococcus lactis;Leukocyte L1 Antigen Complex;Life;Ligands;lipoteichoic acid;Maintenance;manufacture;manufacturing process;manufacturing scale-up;Measurement;Measures;Mediating;Medical;Membrane;microbiome;microbiota;Modeling;Mucous Membrane;Mus;normal microbiota;novel;novel therapeutics;operation;Oral;Oral Administration;overexpression;Pathway interactions;Patients;Pattern recognition receptor;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Play;prevent;Probiotics;Process;Production;Property;Proteins;Qualifying;receptor;Recombinants;Recommendation;Refractory;Research;research clinical testing;response biomarker;Role;Running;safety assessment;Sampling;scale up;side effect;Sigmoidoscopy;Signal Transduction;Signaling Protein;Site;Small Business Innovation Research Grant;Solubility;stool sample;sugar;Surface;Symptoms;Testing;Therapeutic;Time;transcriptome sequencing;Ulcerative Colitis;Universities;vaccine delivery;Validation

PROJECT_TITLE: A Novel Immunological-Directed Live Biotherapy Product for Treating Ulcerative Colitis


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Oncogenic activation by well-defined mutations of the RAS family of GTPases is among the most frequent mutations in human cancers, but there remains a paucity of FDA approved drugs that specifically target most RAS mutants. We have established an innovative strategy, utilizing protein engineering, to identify novel inhibitory agents to each RAS family member and to select mutants. We will extend our study to address important unanswered questions regarding RAS biology, identify vulnerabilities in RAS mutants, and inform the development of cancer therapy that directly targets oncogenic RAS mutants.

PI_NAMEs: KOIDE, SHOHEI ;O'BRYAN, JOHN P (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Affect;Affinity;Alleles;Amino Acids;anti-cancer research;Antibodies;Architecture;Award;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Products;Biological Testing;Biology;Cancer Control;Cancer Patient;cancer therapy;Cause of Death;Cells;Colorectal Cancer;Communities;Complex;Data;Development;Dimerization;Disulfides;empowerment;Engineering;established cell line;Family;Family member;FDA approved;Funding;Genetic;GTP Binding;Guanine;Guanine Nucleotide Exchange Factors;Guanine Nucleotides;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Human;in vivo;inhibitor;innovation;insight;KRAS2 gene;Laboratories;Lobe;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Molecular;mouse model;mutant;Mutate;Mutation;nano;nanocluster;novel;novel strategies;Nucleotides;Oncogenes;Oncogenic;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phase;prevent;Process;Productivity;Protein Engineering;Protein Isoforms;Proteins;RAS genes;RAS inhibition;Ras Inhibitor;Reagent;recruit;Research Personnel;Role;Series;Signal Transduction;Site;small molecule inhibitor;Specificity;success;Synthetic Genes;System;Technology;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;tool;tumor addiction;tumorigenesis;ubiquitin ligase;United States;Work

PROJECT_TITLE: Probing RAS-mediated Signaling with Monobody Inhibitors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Lung;Networking and Information Technology R&D (NITRD);Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease with significant morbidity and mortality. The overall objective of this application is to apply the principles of systems biology to create, refine and validate a cell specific causal model of IPF emergence and progression in the human lung and thus transform our ability to design effective interventions.

PI_NAMEs: BENOS, PANAGIOTIS V;KAMINSKI, NAFTALI  (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Address;Affect;allograft rejection;Alveolar;Animal Model;Architecture;Bioinformatics;Biomedical Engineering;Blood Vessels;causal model;Cell Aggregation;cell injury;Cell Nucleus;Cells;Cellular biology;Cellular Infiltration;Chronic;Collagen;Computational Biology;computer science;Computing Methodologies;Connective Tissue Diseases;Data;data dissemination;data sharing;Deposition;design;Development;Disease;Distal;effective intervention;Epithelial Cells;experimental study;Extracellular Matrix;FDA approved;Fibrosis;fibrotic interstitial lung disease;Foundations;Gene Expression;Generations;Genes;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Grant;Heterogeneity;Histologic;Histology;Human;human model;idiopathic pulmonary fibrosis;Image;Immune;Immunity;insight;Intervention;Lung;lung allograft;Lung Diseases;Machine Learning;Maps;member;Metadata;Methods;microCT;miRNA expression profiling;Modeling;Molecular;Molecular Biology;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;Myofibroblast;novel;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;predictive modeling;Process;Proteomics;Pulmonary Fibrosis;Pulmonary Inflammation;repaired;Resolution;Sampling;Severities;Signal Transduction;single cell technology;statistics;Systems Biology;Techniques;Technology;Therapeutic Intervention;tissue resource;Tissues;tool;transcriptome;transcriptome sequencing;Usual Interstitial Pneumonia;Validation;Work

PROJECT_TITLE: Genomic Analysis of Tissue and Cellular Heterogeneity in IPF

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: Project Narrative This revised application focuses on the discovery that melanoma are selectively addicted to the lysine catabolism enzyme GCDH, which controls NRF2 glutarylation, impacting transactivation of apoptotic UPR signaling in melanoma. The newly discovered GCDH-NRF2-UPR axes constitutes a novel paradigm for control of melanoma survival and offers novel therapeutic targets.

PI_NAMEs: OLSON, STEVEN H;RONAI, ZEEV A. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: activating transcription factor 3;addiction;Address;Advanced Development;anti-PD-1;Antibodies;Apoptosis;Apoptotic;Attenuated;Azoles;Brain Neoplasms;Breast Cancer Cell;cancer cell;CASP3 gene;Catabolism;Cell Death;Cell Death Signaling Process;Cell Line;Cell Survival;Cessation of life;Chemicals;Chemoresistance;Clinical;Data;Development;Dissociation;Effectiveness;Enzymes;Evaluation;Foundations;gene function;Genetic;Genetic Transcription;genome-wide analysis;glutaryl coA;Growth;Human;Immune;Immunotherapy;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Knockout Mice;liquid chromatography mass spectrometry;Liver neoplasms;Lysine;Lysine Degradation Pathway;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Mitochondria;Modality;Modeling;Mole the mammal;Molecular Weight;Monitor;mouse model;Mus;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Outcome;Oxidoreductase;Pathway interactions;Patients;Pharmaceutical Chemistry;Phenocopy;Phenotype;Physiological;Process;Production;prostate cancer cell;Prostatic Neoplasms;Proteins;Regulation;Resistance;Resistance development;response;Sampling;Signal Pathway;Signal Transduction;Site;small molecule;small molecule inhibitor;Specimen;targeted treatment;Testing;therapy resistant;Transactivation;Transcription Coactivator;transcription factor;Transcriptional Activation;treatment response;tumor;Tumor Cell Line;tumor growth;tumor heterogeneity;ubiquitin-protein ligase;Xenograft procedure

PROJECT_TITLE: GCDH Addiction in Melanoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE While scientific talent is distributed broadly across the United States, opportunities to develop such talent are not. We have identified a partnership between the University of Idaho (U of I) and North Idaho College (NIC) as a mechanism to bring biomedical research training opportunities to students in Northern Idaho who would not otherwise have them. Our program will provide students enrolled at NIC an opportunity to engage in independent research before and after transfer to U of I to complete a biomedical bachelor’s degree, with the long-term goal of increasing the size and diversity of the biomedical research workforce.

PI_NAMEs: COOPER, RHENA ;WAYNANT, KRISTOPHER V (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Bachelor's Degree;Biology;Biomedical Research;bridge to the baccalaureate;career;cohort;college;Communication;design;Environment;experience;faculty mentor;Financial Hardship;Goals;Graduation Rates;Idaho;interest;Knowledge;laboratory experience;Learning;matriculation;Mentors;Pathway interactions;programs;recruit;Research;Research Training;Science;Scientist;Self Assessment;Students;Surveys;Training Programs;transfer student;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program T34

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Inherited alteration in BAP1 gene causes wide variety of cancers including eye and skin melanomas, kidney cancer and mesothelioma. In this study we will assess the risk for different cancers in patients who inherit mutation in BAP1. Expected outcomes will include identification of different cancer associated with genetic alterations in BAP1, identification of different mutations that causes the disease and characterization of experimental assay to test for disease causing potential of different genetic alterations in BAP1.

PI_NAMEs: ABDEL-RAHMAN, MOHAMED H. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Apoptosis;BAP1 gene;Benign;Biological Assay;Biological Models;cancer genetics;Cancer Patient;cancer risk;Cell Cycle Regulation;cell growth;cell growth regulation;chromatin remodeling;Classification;Clinical;clinical phenotype;clinical predictors;clinically significant;ClinVar;Code;cohort;Collection;Complex;Counseling;Cutaneous Melanoma;Databases;Deposition;Development;Disease;disease phenotype;disorder risk;DNA Repair;Enhancers;Environmental Risk Factor;Evaluation;evidence base;evidence based guidelines;exome;Experimental Models;Eye;Family;Family member;Frequencies;Gene Expression Regulation;General Population;Genes;Genetic;Genome;Germ Lines;Germ-Line Mutation;Goals;Guidelines;high risk;Hydrolase;In Vitro;Individual;Inherited;International;Lead;Malignant Neoplasms;melanocyte;Melanocytic Neoplasm;Mesothelioma;Modeling;Mutate;Mutation;neoplastic;Nuclear;Oncogenes;Online Mendelian Inheritance In Man;Other Genetics;Outcome;Outcome Study;Pathogenesis;Pathogenicity;patient registry;Patients;Penetrance;Phenotype;population based;Predisposition;programs;promoter;PTEN gene;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Reporting;repository;Research Personnel;Residual state;Resources;Risk Assessment;RNA Splicing;Role;Scientist;screening;skin lesion;Susceptibility Gene;Syndrome;Testing;The Cancer Genome Atlas;translational impact;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Uncertainty;United States National Institutes of Health;Untranslated Regions;Untranslated RNA;Uveal Melanoma;Variant;variant of unknown significance

PROJECT_TITLE: Spectrum of clinical phenotype of the BAP1-tumor predisposition syndrome (BAP1-TPDS)


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Shared decision-making (SDM) ensures that clinical decisions without a single best choice incorporate and reflect patient preferences, thereby promoting patient empowerment, improving transparency, and increasing trust. There are no instruments specifically designed to measure the process of SDM in pediatrics, limiting the evaluation of SDM on health outcomes in this population. The overall goal of this project is to develop and evaluate an instrument to measure the process of SDM with parents of young children.

PI_NAMEs: OPEL, DOUGLAS J (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Development and Evaluation of an Instrument to Measure Shared Decision-Making in Pediatrics

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: KENNESAW

ORG_DEPT: PSYCHOLOGY

ORG_NAME: KENNESAW STATE UNIVERSITY

PHR: Narrative Biomedical research is sorely lacking the presence, voice, and talent of underrepresented scientists with doctoral training. Kennesaw State University and the University of Georgia request funding to conduct a five-year Peach State Bridges to the Doctorate Program with the goals to train five Master’s-level graduate students per year and bridge them into PhD programs in biomedical science. Incumbent to carrying out the NIH mission to diversify this field, this inclusive and nurturing environment will provide high-quality research training for URMs with positive impacts within and between the institutions, thereby increasing the number of URM biomedical PhD- level research scientists.

PI_NAMEs: DYER, KELLY A;GRIFFIN, MELANIE CHRISTINE;HUDSON, MARTIN LYN;MENSA-WILMOT, KOJO A. (contact);WELLS, LANCE

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;Peach

PROJECT_TITLE: Peach State Bridges to the Doctorate


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Microbiome;Neurosciences

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The gut microbiome is emerging as key regulator of complex behaviors, including those associated with neurodevelopmental disorders, but little is known about the underlying mechanism. Here, we will use a series of multidisciplinary and convergent approaches to identify the signals, structures and mechanisms by which a given bacterial species (L. reuteri) regulates a selective behavior (social behavior). We believe that these studies could lead to the development of novel probiotic-based non-invasive treatments for individuals with neurodevelopmental disorders associated with social deficits.

PI_NAMEs: SAHIN, ERGUN  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Amaze;Animals;Area;bacterial genetics;Behavior;Behavioral;Bilateral;Brain;Brain region;Candidate Disease Gene;Central Nervous System Diseases;commensal bacteria;Complex;Data;Development;Dimensions;Disease;Dissection;DNA Sequence Alteration;Electrophysiology (science);Engineering;Environmental Risk Factor;Etiology;Exhibits;Fiber;gain of function;Generations;Genes;Genetic;genetic makeup;Genetic Models;Genetic Screening;Goals;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Impairment;improved;Individual;insight;Laboratories;Lactobacillus reuteri;loss of function;maternal obesity;Mediating;metabolomics;Metagenomics;microbial;microbial based therapy;Microbial Genetics;Microbiology;microbiome alteration;microorganism;Modeling;Molecular;mouse model;multidisciplinary;Mus;Neurodevelopmental Disorder;Neurons;Neurosciences;novel;offspring;optogenetics;Oxytocin;Pathway interactions;Pharmacology;Physiology;Prevalence;prevent;Probiotics;Reproducibility;Research;Rewards;Role;Series;Signal Pathway;Signal Transduction;social;Social Behavior;social deficits;Structure;synaptic function;Synaptic plasticity;System;Testing;tetrahydrobiopterin;Therapeutic;transcriptome sequencing;transcriptomics;Vagotomy;Vagus nerve structure;Work

PROJECT_TITLE: Unraveling gut-microbiome-brain interactions in neurodevelopmental disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The overall goal of our project is to validate a diagnostic tool for dementia with Lewy bodies, and Parkinson’s disease dementia, two common neurological diseases currently affecting 1.4 million people in the U.S. Our study may ultimately help early diagnosis to improve patient care and aid the development of therapeutics for patients living with dementia with Lewy bodies and Parkinson’s disease dementia.

PI_NAMEs: CHEN, SHU G. (contact);KRAUS, ALLISON L

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Age;alpha synuclein;Alzheimer's Disease;atypical parkinsonism;Autopsy;Biological Assay;Biological Markers;biomarker identification;Biopsy;Biopsy Specimen;Brain;Cadaver;Caring;Central Nervous System;Cerebrospinal Fluid;Clinical;Clinical Trials;cohort;Colon;Colonoscopy;comorbidity;comparison group;corticobasal degeneration;Dementia;Dementia with Lewy Bodies;Deposition;Detection;Diagnosis;diagnostic biomarker;diagnostic strategy;Diagnostic tests;diagnostic tool;Differential Diagnosis;Disease;Early Diagnosis;Emerging Technologies;Enteric Nervous System;follow-up;Functional disorder;Goals;Hypersensitivity skin testing;Immunologics;improved;Lewy Body Dementia;Measures;Medical;Methods;Nervous System Disorder;Neurodegenerative Disorders;neuropathology;Nose;Parkinson's Dementia;Parkinsonian Disorders;participant enrollment;Patient Care;Patient Recruitments;patient stratification;Patients;Peripheral;Persons;prion-like;Progressive Supranuclear Palsy;protein aggregation;Reporting;Salivary Glands;Sampling;Sensitivity and Specificity;Severity of illness;Sigmoid colon;Sigmoidoscopy;Skin;skin biopsy;Specimen;Spinal Puncture;Submandibular gland;Symptoms;synucleinopathy;tau aggregation;tau Proteins;Tauopathies;Testing;therapeutic development;Time;tissue biomarkers;Tissues

PROJECT_TITLE: Peripheral Tissue Biomarker for Premortem Diagnosis of Lewy Body Dementia


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Obesity and metabolic disorders are increasing in epidemic proportions in the country which ultimately leads to poor outcomes including heart failure. AKT substrate of 160kDa (AS160) has been identified as nodal regulator between insulin signaling and glucose uptake, but research into its physiological role in cardiomyocyte metabolism has been hampered by limitations of available models. In this context, our studies are focused on elucidating the composition of the cardiac AS160 regulatory complex, how this complex and AS160 regulation is altered during disease, and the effect on cardiomyocyte metabolism in order to develop novel therapeutic strategies for cardioprotection in obesity and obesity related metabolic syndromes.

PI_NAMEs: SCHUMACHER, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: abdominal fat;Adipocytes;adipokines;Adipose tissue;ADRBK1 gene;Adult;Adverse effects;Affect;American;atherosclerosis risk;Binding;Biological Markers;Biology;Body mass index;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;cardiometabolism;cardioprotection;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Central obesity;Chronic;Co-Immunoprecipitations;Complex;Consensus;Country;crosslink;Cues;Data;Death Rate;Diabetes Mellitus;Diet;diet-induced obesity;Disease;driving force;Epidemic;flexibility;Functional disorder;G protein coupled receptor kinase;genetic risk factor;glucose uptake;GLUT 4 protein;Goals;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;High Fat Diet;Homeostasis;Human;Immunoprecipitation;improved;inhibitor;insight;Insulin;insulin receptor substrate 1 protein;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;interest;Intervention Studies;Investigation;knock-down;Knock-in;Knock-out;Knowledge;Left;Length;Life Style;Link;Mass Spectrum Analysis;Mediating;Membrane;men;Metabolic;Metabolic Diseases;Metabolic stress;Metabolic syndrome;Metabolism;Mitochondria;Modeling;mouse model;Mus;Mutation;Myocardial dysfunction;N-terminal;Nodal;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;novel therapeutic intervention;obese person;Obesity;Organ;Outcome;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Peptides;Performance;Phenotype;Phosphorylation;Phosphotransferases;Physiological;preservation;pressure;Protein Inhibition;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;recruit;Regulation;Research;Respiration;response;Role;Sampling;Severity of illness;Signal Transduction;Skeletal Muscle;small molecule;Stress;Stroke;systemic inflammatory response;targeted treatment;Tertiary Protein Structure;Therapeutic Intervention;therapeutic target;Tissue Sample;trafficking;Translating;United States;uptake;Ventricular;Vesicle;Visualization;Woman;Work

PROJECT_TITLE: AS160 as a nodal regulator of the cardiac response to metabolic stress

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Early liver transplantation (elT), defined as LT evaluation with <6 months of alcohol abstinence, is associated with acceptable outcomes for patients with severe alcohol-associated liver disease (ALD) in retrospective studies. However, prospective, multi-center data including biopsychosocial factors on elT for all patients with ALD in racially, culturally, and socioeconomically diverse populations are lacking. The INTEGRATE collaborative is a highly diverse investigative team that seeks to: 1) define factors influencing referral and waitlisting for elT in ALD (selection); 2) identify which biopsychosocial factors are causally related and predictive of outcomes most important to stakeholders (outcomes); and 3) determine how integrated care among the healthcare team influences stakeholder-relevant outcomes in elT for ALD (management).

PI_NAMEs: VERNA, ELIZABETH CLARICE (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;access disparities;Address;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Behavioral Research;Biological Factors;biopsychosocial;biopsychosocial factor;candidate selection;career;Caregivers;Caring;Cirrhosis;Clinical;cohort;Communication;County Hospitals;Data;data harmonization;design;ethnic diversity;Ethnic Origin;Evaluation;Family;Focus Groups;Funding;Geographic Locations;health care disparity;health disparity;Hepatitis;improved;innovation;integrated care;Interview;Knowledge;Liver diseases;liver transplantation;Longitudinal cohort;Measures;Medical;Medical Care Team;Medical center;Medicine;member;Mental Health;Methodology;Methods;Michigan;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;organ allocation;Organ Donor;Organ Procurements;Outcome;outcome prediction;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Perception;Population;Population Heterogeneity;Positioning Attribute;preference;Process;prospective;Protocols documentation;Provider;Psychological Factors;Qualitative Evaluations;Race;racial diversity;Recurrence;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Retrospective Studies;Risk;risk prediction model;sex;social health determinants;socioeconomics;Sodium Chloride;stakeholder perspectives;Standardization;substance use;Surveys;survival prediction;Techniques;Texas;Time;transplant centers;transplant model;Transplantation;Underinsured;United States National Institutes of Health;Universities;virtual;Waiting Lists;Work

PROJECT_TITLE: 2/4-The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopschosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease


ORG_DEPT: FAMILY MEDICINE

PHR: Narrative The proposed research is relevant to public health because reducing contaminated urine cultures will help reduce unnecessary antibiotic use, slow emergence of antimicrobial resistance, and preserve the effectiveness of antibiotics for current and future generations. Reducing contaminated urine cultures will also reduce waste of laboratory resources and decrease costs for patients and healthcare institutions. The proposed research is also relevant to the National Action Plan for Combating Antibiotic-Resistant Bacteria because it will improve accuracy of a diagnostic test commonly used to detect resistant bacteria.

PI_NAMEs: GRIGORYAN, LARISA  (contact);TRAUTNER, BARBARA WELLS

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: A Randomized Controlled Trial of a Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Neurosciences;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE Residents of northern Lake County, Indiana, have expressed great concern regarding the potential health impacts resulting from ongoing release of environmental pollutants from the area’s numerous metal, petroleum, and chemical industries. There is substantial scientific data that exposure to individual metals and volatile organic compounds can result in neurotoxicity and other health outcomes; however, there is very little information regarding the cumulative impact of exposure to a complex mixture of these compounds. This community- engaged research project will address both knowledge gaps by characterizing resident exposure to multiple environmental chemicals, determining the association of exposure to these mixtures with self-reported health outcomes and neurological function.

PI_NAMEs: WELLS, ELLEN M (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Adsorption;Adult;Air;air sampling;Area;Aromatic Polycyclic Hydrocarbons;Arsenic;Benzene;Biological;Characteristics;Chemical Exposure;Chemical Industry;Chemicals;Child;Cognition;Cognitive;cognitive function;cognitive testing;Collection;Communities;community academic partnership;community advisory board;community engaged approach;community engaged research;community engagement;Community Health Aides;Community Outreach;Complex;Complex Mixtures;cost;County;Cross-Sectional Studies;Data;Data Collection;Dust;Effectiveness;effectiveness evaluation;elementary school;emotional functioning;Employment;empowerment;Ensure;environmental chemical;Environmental Hazards;Environmental Health;Environmental Pollutants;Environmental Pollution;Epigenetic Process;ethylbenzene;Evaluation;Event;Excision;experience;Exposure to;fine particles;Future;Gases;Genes;genome wide methylation;Geographic Information Systems;Goals;Hair;Health;Health Status;Home;House Dust;Housing;improved;Indiana;Individual;Inductively Coupled Plasma Mass Spectrometry;Institution;interest;Knowledge;Laboratories;Lead;Low income;mass spectrometer;member;Memory;Metal exposure;Metals;Methods;Methylation;methylation pattern;Modeling;Monitor;multidisciplinary;Nail plate;Nervous System Disorder;Nervous System Physiology;Neurologic;neurotoxicity;Outcome;Participant;Particulate Matter;Patient Recruitments;Patient Self-Report;Pattern;Petroleum;physical conditioning;population health;Principal Component Analysis;Process;Program Evaluation;Protocols documentation;Public Health;Questionnaires;recruit;Regression Analysis;Research;Research Project Grants;Roentgen Rays;Saliva;saliva sample;Sampling;Scientist;Silicones;Soil;soil lead;Standardization;Steel;Structure of nail of toe;superfund site;System;Testing;Toluene;toxic metal;toxicant;Training;United States National Institutes of Health;Universities;videoconference;Visit;Voice;volatile organic compound;Volatilization;Water;Work;wristband;Xylene

PROJECT_TITLE: Community-academic partnership to address environmental contamination and health

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed dissertation work will contribute to the fundamental knowledge with longitudinal empirical evidence on the influence of physical, social environmental factors on social isolation and cognitive health, and contextualized the role of technology use. The postdoctoral research will build knowledge on the behavioral and contextual pathways that could explain the association between social isolation and cognitive decline in later life. Knowledge to be built in the predoctoral and postdoctoral stages will be synthesized to inform the development of a technology-facilitated community-based intervention program to reduce social isolation and prevent cognitive decline among older adults.

PI_NAMEs: YU, KEXIN  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Access to Information;Address;Adopted;Affect;Age;Aging;aging process;Alzheimer's disease related dementia;Attention;Behavior Therapy;Behavioral;behavioral health intervention;Brain;Cardiovascular Diseases;Characteristics;clinical trial participant;Clinical Trials;Cognitive;cognitive function;cohesion;Communication;Communities;community intervention;Complex;Data;Data Analyses;design;Development;Digital biomarker;Disadvantaged;Disease;effectiveness evaluation;Enhancement Technology;Environment;Environmental Risk Factor;Equation;executive function;experience;Foundations;Goals;Health;Health Status;high risk;Home;Impaired cognition;improved;Independent Living;Individual;Internet;Intervention;intervention delivery;intervention program;Intervention Studies;Knowledge;late life;Life;Literature;lonely individuals;Measures;Mediating;Medical Technology;Methods;Modeling;multilevel analysis;Neighborhoods;neuroimaging;Neuropsychology;older adult;Older Population;Outcome;Participant;Pathway interactions;Personality;Persons;Phase;physical conditioning;Physical environment;Play;Population;Postdoctoral Fellow;pre-doctoral;prevent;Process;protective factors;Protocols documentation;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;Role;satisfaction;Shapes;social;Social Characteristics;social engagement;Social Environment;Social Interaction;Social isolation;Social Well-Being;Stimulus;systematic review;Technology;technology platform;Testing;theories;tool;trend;Work;β-amyloid burden

PROJECT_TITLE: Examining the Longitudinal Influence of the Physical and Social Environments on Social Isolation and Cognitive Health: contextualizing the role of technology


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This program trains MDs, MD/PhDs, and PhDs for careers as independent researchers in schizophrenia and psychotic disorders. An intensive three-year program of didactics and execution of research is described. Fellows learn to identify research questions, formulate hypotheses, design and execute experiments to test those hypotheses, understand effective collaboration with other researchers and the administrative organization of a successful research program, and write grants to obtain funding from federal agencies and private foundations.

PI_NAMEs: KELLENDONK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Training in Schizophrenia and Psychotic Disorders: From Animal Models to Patients


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The proposed studies are relevant to public health because discovery of novel drugs to treat colorectal cancer represents a significant unmet need in oncology. This work is thus relevant to NIH's mission to develop impactful new treatment for colorectal cancer, the second deadliest cancer in the world.

PI_NAMEs: NEAMATI, NOURI  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;anti-PD1 antibodies;Bioinformatics;Bromouridine sequencing;cancer cell;Cell Adhesion Molecules;Cell Line;Cell Survival;Cells;chemotherapy;Clinical;clinical candidate;clinical development;Clinical Research;Colorectal Cancer;colorectal cancer treatment;Complex;Coupled;CRISPR/Cas technology;Critical Pathways;Data;design;Down-Regulation;Drug Combinations;Drug resistance;Drug Targeting;druggable target;efficacy study;Engineering;Fluorouracil;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Transcription;GSTO1 gene;immune activation;Immune checkpoint inhibitor;Immune response;Immunotherapy;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;Innate Immune Response;innate immune sensing;insight;Interferon Type I;Interferons;Interleukin-1 beta;irinotecan;Knock-out;lead optimization;Link;Malignant Neoplasms;Mediating;Microsomes;Mission;Modeling;monocyte;multiple omics;Names;Natural Immunity;Neoplasm Metastasis;neoplastic cell;novel;novel anticancer drug;novel therapeutics;Oncology;overexpression;oxaliplatin;Pathway interactions;patient derived xenograft model;Patients;pharmacodynamic biomarker;pharmacologic;preclinical development;protein expression;Protein Isoforms;Proteomics;prototype;Public Health;rational design;Regulation;response;Risk Factors;Role;Series;simulation;small hairpin RNA;Small Interfering RNA;small molecule;small molecule inhibitor;spheroids;Structure;synergism;Testing;Therapeutic;therapeutic target;Thromboplastin;Time;tool;transcriptome sequencing;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Preclinical Development of First-in-Class GSTO1 Degraders for Colorectal Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Rare Diseases;Stomach Cancer

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Gastric carcinogenesis develops in a sequential progression of a carcinogenic cascade from pre-cancerous metaplasia to cancerous dysplasia and adenocarcinoma. This project will focus on the oncogenic roles of Kras activation as a driving force for carcinogenic transition in gastric carcinogenesis using novel transgenic mouse models.

PI_NAMEs: CHOI, EUNYOUNG  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Adenocarcinoma;Alleles;Automobile Driving;Biology;Cancer Etiology;Cancerous;carcinogenesis;carcinogenicity;Cell Lineage;Cells;Cessation of life;Chief Cell;Colon Carcinoma;design;Development;Doxycycline;driving force;Dysplasia;Event;Evolution;Family;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric Chief Cells;gastric pre-neoplasia;Genes;Genetic Transcription;genomic locus;Gland;Goals;Histologic;Human;In Vitro;in vivo;Individual;insight;Intestines;Intrinsic factor;Investigation;Kinetics;Knowledge;KRAS oncogenesis;Maintenance;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Metaplasia;Molecular;mouse model;Mus;new therapeutic target;novel;Oncogenic;Outcomes Research;overexpression;Patients;pre-clinical;premalignant;preventive intervention;Process;RNA;Role;Signal Pathway;Stomach;Therapeutic Intervention;Tissues;transcription factor;Transcriptional Regulation;transdifferentiation;Transgenic Mice;Up-Regulation;Zymogen Granules

PROJECT_TITLE: Drivers of gastric pre-neoplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Among the 40% of patients with an HLA-B44 supertype allele, greater clinical activity of programmed cell death 1 (PD-1) inhibitors is seen when mutations lead to peptides in which a neutral or positively charged amino acid is substituted with a negatively charged amino acid, presumably based on favorable binding to the positively charged HLA-B44 binding pocket. We propose comprehensive studies to characterize the effects of these specific mutational events on the tumor microenvironment. We will also evaluate whether these specific mutational events can assist in directing patients to appropriate therapeutic approaches in both early and advanced stage non-small cell lung cancer.

PI_NAMEs: GARON, EDWARD B (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Adjuvant Chemotherapy;Agreement;Algorithms;Alleles;Amino Acid Substitution;Amino Acids;anti-tumor immune response;antigen binding;Antigen Presentation;Antigens;bak protein;Binding;Biological Markers;biomarker evaluation;biomarker identification;Biopsy;Cancer Etiology;Cancer Patient;Cessation of life;Charge;chemotherapy;Clinical;clinical care;Clinical Data;clinically relevant;Combination Drug Therapy;combinatorial;Data;Development;Disease;Disease Progression;Disease-Free Survival;Dissociation;Early identification;Electrostatics;Epidermal Growth Factor Receptor;Ethnic Population;Evaluation;Event;exome sequencing;Gene Expression;Gene Expression Profile;genetic signature;HLA Antigens;Immune;immune checkpoint;Immune response;Immunofluorescence Immunologic;Immunologic Markers;Immunologics;improved;In complete remission;Inflammatory;inhibitor;Lead;Ligands;Malignant neoplasm of lung;Methods;Minority;Mismatch Repair Deficiency;Modeling;Mutation;Neoadjuvant Therapy;neoantigens;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;outcome prediction;Pathologic;patient population;Patient Selection;Patients;Peptides;Peripheral Blood Mononuclear Cell;Population;Positioning Attribute;predict clinical outcome;predictive marker;Predictive Value;Prevalence;programmed cell death ligand 1;programmed cell death protein 1;racial population;response;Role;Sampling;single-cell RNA sequencing;Slide;spatial relationship;Specimen;standard of care;Testing;The Cancer Genome Atlas;Therapeutic;transcriptomics;treatment strategy;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;United States;Up-Regulation

PROJECT_TITLE: HLA B44 motif neoepitopes in NSCLC: Evaluating their effects on the TME and adding them to established markers in a model to predict durable benefit from PD- 1 inhibition with and without chemotherapy

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Neoadjuvant chemotherapy is commonly applied to women with breast cancer and monitoring tumor response to chemotherapy is currently based on tumor size measured by physical exam, which is subjective, difficult to quantify, and most importantly, temporally delayed compared to underlying biological changes. Quantitative, reproducible, and objective methods that could provide an early detection of tumor physiological changes before size changes could significantly improve treatment outcome and the quality of patient care. Here, we propose to leverage Magnetic Resonance Fingerprinting (MRF), a new platform for quantitative MR imaging that was developed by our team, to develop new imaging biomarkers for early assessment of treatment response in women with breast cancer, with the ultimate goal to reduce ineffective treatment in eligible subjects and tailor the treatment methods for optimum therapeutic outcomes.

PI_NAMEs: CHEN, YONG  (contact);MA, DAN ;MARSHALL, HOLLY

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: 3-Dimensional;Acceleration;Adjuvant Chemotherapy;Adoption;algorithm training;Antibodies;Biological;Brain Mapping;Breast;breast exam;breast imaging;breast lesion;breast surgery;cancer diagnosis;Cancer Etiology;Cessation of life;Characteristics;chemotherapy;Clinical;clinical translation;cloud based;cohort;Computers;Consumption;convolutional neural network;cost;Data;deep learning;Development;diagnostic accuracy;Dictionary;Diffusion;Diffusion Magnetic Resonance Imaging;early detection biomarkers;Early Diagnosis;Eligibility Determination;ERBB2 gene;Exhibits;experimental study;Female;Fingerprint;Genetic;Goals;healthy volunteer;Heterogeneity;hormone therapy;Image;imaging biomarker;improved;In complete remission;individualized medicine;ineffective therapies;invention;Lesion;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammary Neoplasms;Maps;Measurement;Measures;Methods;Monitor;Morphology;Multiparametric Analysis;Neoadjuvant Therapy;novel;Operative Surgical Procedures;partial response;Pathologic;Patient Care;patient response;Patients;Phenotype;Physicians;Physics;Physiological;Prediction of Response to Therapy;Preparation;Prone Position;quantitative imaging;reconstruction;Relaxation;Reproducibility;research clinical testing;research study;Resolution;response;Sampling;Scanning;side effect;Standardization;targeted treatment;Techniques;Therapeutic;therapy outcome;Time;tissue mapping;tool development;Treatment outcome;treatment planning;treatment response;trend;triple-negative invasive breast carcinoma;tumor;Variant;Visualization;volunteer;Woman

PROJECT_TITLE: Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The insights from this grant will be critical to our understanding of the evolutionary origin of human adaptations and the health implications of historical population admixture. The novel methods that we will develop will allow an unprecedented level of resolution regarding the origin of genomic segments and mutations and when and why they had been selected. These insights will allow an accurate interpretation of the landscape of introgression and admixture across human genomes and will ultimately provide a key element for realizing personalized genomics and the utilization of individual genomic ancestry profiles for medicine.

PI_NAMEs: HUBER, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Admixture;Africa;Age;Alleles;Appearance;Data;detection method;DNA;Elements;emerging pathogen;Environment;European;Event;Evolution;Genetic;Genetic Recombination;Genetic Variation;Genomic Segment;Genomics;Grant;Graph;Health;Human;human data;Human Genetics;Human Genome;human genomics;Individual;insight;Knowledge;Learning;Medicine;Methods;microbiome;migration;Modeling;Modernization;Mutation;Natural Selections;novel;pathogen;personalized genomic medicine;personalized genomics;Population;population based;Population Genetics;Population Sizes;pressure;Recurrence;Resolution;Role;Sampling;skeletal;Statistical Methods

PROJECT_TITLE: The role of admixture in human evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE As a member of NCORP’s integrated network of community organizations and research bases, the Kaiser Permanente (KP) NCORP Community Site will bring medical advances to the community at large by increasing clinical trial access and accrual to cancer control, prevention, symptom management, imaging, treatment, and cancer care delivery research. KP’s integrated health plan presents an ideal platform for accelerating the translation of findings into clinical practice.

PI_NAMEs: SUGA, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Address;Affect;Ancillary Study;anti-cancer research;Area;base;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;cancer imaging;Cancer Patient;Cancer Prevention Trial;cancer therapy;Cancer Therapy Evaluation Program;care delivery;Caring;Clinical;clinical practice;clinical trial enrollment;Clinical Trials;clinically significant;Collaborations;Communities;Community Clinical Oncology Program;community involvement;Community Networks;community organizations;community research;comorbidity;Data;data harmonization;data infrastructure;data management;Dedications;Disparity;Dissemination and Implementation;Education;Elderly;electronic medical record system;Electronics;Eligibility Determination;Enrollment;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Funding;Genomics;Geography;Goals;Grant;health care delivery;health determinants;health disparity;health plan;Healthcare Systems;Image;imaging study;improved;Informatics;insight;Institution;Intervention Studies;knowledge translation;Leadership;Malignant Neoplasms;Medical;medical specialist;member;Mentors;Methods;Minority;Minority Groups;Minority Participation;Modeling;National Clinical Trials Network;novel strategies;Observation in research;Office of Administrative Management;Oncologist;Oncology;Outcome;outreach program;participant enrollment;Patient Outcomes Assessments;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Patterns of Care;Population;Population Heterogeneity;Prevention;primary care clinician;programs;protocol development;Protocols documentation;Provider;Quality of life;Race;racial diversity;racial minority;recruit;Research;Research Design;Research Personnel;research study;Scientist;screening;Shapes;Site;social factors;Southwest Oncology Group;Structure;symptom management;System;team-based care;Training;Training and Infrastructure;Translations;trial enrollment;Underrepresented Populations;Underserved Population;webinar;Work;working group

PROJECT_TITLE: Kaiser Permanente NCI National Community Oncology Research Program, NCORP


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE During HIV-1 replication, its proteins are covered in sugar molecules derived from the infected cell. The dense coat of host sugar molecules covers the virus-specific targets on the viral protein, allowing HIV-1 to circumvent proteins made by the immune system called antibodies. We have found a novel subset of antibodies, with an atypical shape, that are able to recognize the HIV-1 envelope protein via the dense shield of sugar molecules that normally inhibits antibody recognition. These antibodies, when found in macaques infected with the macaque version of HIV-1, exhibited broad inhibitory activity against HIV-1 infection. This type of antibody could be part of an effective antibody response if elicited by vaccination. Using these antibodies as a template, we developed a vaccine that focuses the immune response against the sugars on HIV-1 proteins. We will test whether our vaccine that presents only the appropriate type and number of sugar molecules can elicit broad and potent inhibitory antibodies in macaques.

PI_NAMEs: SAUNDERS, KEVIN O (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Affinity;Amino Acids;Animal Model;Antibodies;Antibody Affinity;Antibody Binding Sites;Antibody Response;Antigens;arm;Autologous;B-Lymphocytes;Binding;Biochemical;Biochemistry;booster vaccine;Categories;Cells;complementarity-determining region 3;Dependence;design;Development;Dimerization;Elements;env Gene Products;Epitopes;Exhibits;Genes;Genetic;Glycopeptides;Glycoproteins;glycosylation;Goals;Grant;Heterogeneity;HIV;HIV Antibodies;HIV-1;HIV-1 vaccine;Human;Immune response;Immune system;Immunogenetics;immunogenic;Immunoglobulin G;Infection;inhibiting antibody;innovation;Investigation;Macaca;Macaca mulatta;Mannose;mannosyl(9)-N-acetylglucosamine2;Molecular Conformation;Monoclonal Antibodies;nanoparticle;neutralizing antibody;neutralizing vaccine;novel;Phenotype;Polysaccharides;prevent;Primates;Proteins;Race;Reproducibility;Serum;Shapes;simian human immunodeficiency virus;Site;Structure;sugar;surface coating;Testing;Vaccinated;Vaccination;Vaccine Design;vaccine development;Vaccines;Viral Proteins;Virus;Work

PROJECT_TITLE: HIV-1 vaccine-elicited antibodies target envelope glycans

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]