NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Patients with structural heart disease such as myocardial infarction and heart failure are at high risk of ventricular arrhythmias that progress to sudden cardiac death. In current study, we propose an innovative strategy to chemically ablate peripheral ganglia functions with minimal surgical intervention. These data will be important in developing novel therapies for reducing cardiovascular dysfunction in chronic heart failure.

PI_NAMEs: DUAN, BIN ;WANG, HANJUN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Accounting;Adrenergic beta-Antagonists;Adult;Affect;angiogenesis;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Animal Experiments;Apoptosis;Arrhythmia;Bilateral;Biological;Biopolymers;Blood Vessels;Cardiac;Cardiac ablation;Cardiac Surgery procedures;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cell Death;Chemicals;Clinic;Complex;Congestive Heart Failure;Conscious;coronary fibrosis;Data;density;Developed Countries;Development;Diagnosis;disabled;Disease;Disease Progression;Dose;Drug Delivery Systems;Drug resistance;Echocardiography;Electric Countershock;Electric Stimulation;Electrocardiogram;Encapsulated;Endothelial Growth Factors Receptor;Endothelium;Epidemic;Event;FDA approved;Female;Foundations;Functional disorder;Ganglia;Ganglionectomy;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;high risk;Hour;Hydrogels;Implantable Defibrillators;improved;In Vitro;in vivo;Injectable;Injections;innovation;Life;Link;Local Anesthetics;LoxP-flanked allele;male;Maps;Measures;Mediating;Medical;Methods;Microspheres;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial dysfunction;Myocardial Infarction;Nature;Nerve;Neuroendocrine Tumors;neuron apoptosis;Neurons;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Patients;Peripheral;Persons;Pharmaceutical Preparations;pressure;prevent;Procedures;Protein Tyrosine Kinase;Quality of life;Rattus;Recommendation;Recurrence;Refractory;Reporter;Research;response;Rodent;Sensory Ganglia;Signal Pathway;small molecule;Solid;structural heart disease;Structure of stellate ganglion;Subgroup;sudden cardiac death;Sympathectomy;Sympathetic Ganglia;System;Tachycardia;targeted delivery;Techniques;Technology;Telemetry;Therapeutic Effect;therapeutic target;Three-Dimensional Imaging;Tissues;treatment choice;Treatment Efficacy;United States;vascular bed;Vascular blood supply;Vascular Endothelial Growth Factors;Ventricular Arrhythmia;Ventricular Tachycardia;Work

PROJECT_TITLE: Novel Stellate Ganglia Chemo-ablation Approach to Treat Cardiac Arrhythmia and Cardiac Remodeling in Heart Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Influenza remains a persistent global health threat especially among higher risk patients. In this study, we propose that a unique population of cells in the lung regulate the host response to influenza A infection. The proposed studies will further define this cell and will identify host immune pathways used by this cell to control viral infection.

PI_NAMEs: HENAO VASQUEZ, JHONATAN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;airway epithelium;Anti-viral Agents;Area;Binding;Biology;Bone Marrow;Bone Marrow Cell Transplantation;career;Cells;Cessation of life;Chimera organism;Critical Pathways;Data;Development;dimension reduction;Disease;Effectiveness;Effector Cell;Epithelial Cells;Exhibits;experimental study;Flow Cytometry;flu;Foundations;Future;genome integrity;Germ Cells;Germ Lines;global health;Goals;Growth;Harvest;Hematopoietic;Heterozygote;high risk;Homozygote;Host Defense;Immune;immune function;Immune response;Immunity;immunoregulation;Infection;Inflammatory;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;Knock-in;Lung;lung development;Modeling;mouse model;Mus;Nature;novel;novel therapeutics;particle;Pathway interactions;Patients;Play;Population;Process;Protein Family;Proteins;PTPRC gene;Public Health;Puerto Rico;Reporter;Research;Research Personnel;Respiratory Tract Infections;response;Retrotransposon;RNA;Role;Saline;Seasons;Sequence Alignment;single cell sequencing;single-cell RNA sequencing;Somatic Cell;Spermatogenesis;Testis;Training;transcriptomics;Tropism;vaccine access;Vaccines;Viral;Viral Pathogenesis;viral RNA;Virion;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Lung MIWI2 and the host defense against Influenza A virus


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE The current application aims to address health disparities experienced by African Americans— established as a central public health priority—through an examination of racial stigma experiences which have been found to contribute to substance use vulnerability. Substantial information about stress, executive functioning, and emotional processing has emerged in the field of cognitive neuroscience and there are exciting new opportunities to assess these types of processes underlying responses to racial stigma. Deeper understanding of these core processes will offer important new information and form a clear basis from which to develop targeted prevention/intervention strategies.

PI_NAMEs: RISCO, CRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Acute;Address;Affective;African American;African American population;Arousal;Behavior;Behavioral;behavioral health;Brain;career development;Cognitive;cognitive control;cognitive neuroscience;Collaborations;Communities;Complex;Computers;coping;cue reactivity;Cues;Data;design;Development Plans;Electroencephalography;Emotional;ethnic health disparity;Event;Event-Related Potentials;executive function;experience;Exposure to;Feedback;Frequencies;health disparity;heuristics;Imagery;indexing;Individual;Individual Differences;insight;Intervention;Joints;Laboratories;Learning;Link;Literature;Maps;Measurement;Measures;Medial;member;Mentors;Methodology;Methods;Modeling;multilevel analysis;Negative Valence;neural;Neurobiology;neurophysiology;novel;Outcome;Parietal;Pathway interactions;Patient Self-Report;Perception;Performance;Phase;Positive Valence;Predisposition;Prevention;Process;promote resilience;Protocols documentation;Psychopathology;psychosocial stressors;public health priorities;Race;racial discrimination;racial disparity;racial identity;Recovery;Reporting;Research;Research Domain Criteria;response;reward processing;Rewards;Risk;Risk Behaviors;Sampling;skills;social stigma;Stress;stress reactivity;substance use;System;Time;time use;Training;vigilance;Work;young adult

PROJECT_TITLE: Racial Stigma and Substance Use Vulnerability Among African American Young Adults: Examining Cognitive and Affective Mechanisms

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative / Public Health Relevance This proposal aims to evaluate the relationships of brain PET and MRI markers with cognition and genetics in mild cognitive impairment/Alzheimer’s disease patients and normal controls. By leveraging complementary information of amyloid PET, tau PET, MRI, cognitive, clinical, and genetic markers via machine learning methods, this study will elucidate the first evidence on whether there are potential subgroups of patients relative to controls and show their differential relationships among these markers. Upon success, this will provide a rationale for designing larger-scale future studies and ultimately aid in precision medicine for the diagnosis and treatment of patients with Alzheimer’s disease. 1

PI_NAMEs: CHAND, GANESH  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;anatomic imaging;Apolipoprotein E;Behavior;Behavioral;behavioral phenotyping;Brain;brain based;Brain region;Clinical;Clinical Markers;clinical phenotype;Cognition;Cognitive;cognitive performance;Complex;Computer Assisted;Data;Data Set;deep neural network;Dementia;design;Diagnosis;Diagnostic;disease heterogeneity;Disease Outcome;Exhibits;Functional disorder;Future;Gene Expression Profile;Genetic;Genetic Markers;Goals;Heterogeneity;Image;imaging biomarker;imaging modality;improved;improved outcome;in vivo;innovation;Knowledge;Machine Learning;machine learning method;machine learning model;machine learning prediction;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Mental disorders;mental state;Methods;mild cognitive impairment;molecular imaging;Multimodal Imaging;Nerve Degeneration;Neural Network Simulation;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuropathology;neuropsychiatric disorder;novel;Outcome;Participant;patient subsets;Patients;Pattern;Persons;Phenotype;polygenic risk score;Positron-Emission Tomography;pre-clinical;precision medicine;Precision therapeutics;Preparation;prognostic;Psychoses;public health relevance;Research;research clinical testing;Research Personnel;Science;Senile Plaques;Subgroup;success;Sum;supervised learning;support vector machine;Symptoms;targeted treatment;tau Proteins;Techniques;Testing;Therapeutic;therapeutic biomarker;Translating;treatment response;United States;Universities;Variant;Washington

PROJECT_TITLE: Characterizing Alzheimer's disease molecular and anatomical imaging markers and their relationships with cognition and genetics using machine learning

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: The goal of the proposed Multilevel Interventions to Advance Maternal Health Equity (MIRACLE) Center is to reduce pregnancy-related and pregnancy-associated maternal morbidity and mortality (PRAMM) disparities in African American, Hispanic, and rural populations through innovative and culturally relevant community- partnered effectiveness and implementation research. This Center will address the need for multilevel, com- munity-centered, equity-focused interventions for PRAMM disparities, which are developed and tested with an emphasis on scalability and sustainment.

PI_NAMEs: JOHNSON, JENNIFER E;MEGHEA, CRISTIAN IOAN (contact);VANDER MEULEN, MARGARET

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Academic support;Address;Affect;African American;antenatal;Area;Basic Science;Birth;Black race;brief motivational intervention;Caring;Cessation of life;checkup examination;clinical care;Communication;Communities;community engaged approach;community engagement;Community Health;Community Health Aides;Community Healthcare;community organizations;community partners;community partnership;community setting;community-centered;comorbidity;cost effectiveness;County;Data;Data Analytics;data harmonization;Data Set;design;Development;digital;digital platform;Discipline;Discipline of Nursing;Disparity;Economics;Education;effectiveness evaluation;effectiveness research;Emergency Medicine;Epidemiology;Equity;Family;Financial Support;Goals;Health;health administration;health equity;Health system;Hispanic;Hispanic Populations;Home visitation;hospital care;Hospitals;implementation research;implementation science;implementation trial;improved;Inequity;innovation;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Link;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal safety;Measures;Medicaid;Medicaid eligibility;Methods;mHealth;Michigan;mobile computing;Morbidity - disease rate;mortality;mortality disparity;Mothers;multiple chronic conditions;novel strategies;Observational Study;Outcome;Outpatients;Participant;Patients;Persons;Phase;Policies;Population;Postpartum Period;Pregnancy;pregnancy related death;pregnant;programs;Provider;Psychology;Public Health;Public Policy;Quality of Care;Racial Equity;Recording of previous events;Records;Research;Risk;rural area;Rural Population;rural setting;scale up;Science;screening;Secure;Services;severe maternal morbidity;Sociology;Source;statistics;Structure;System;Technology;Testing;Text;Training;Translations;trial design;urban setting;Work

PROJECT_TITLE: Maternal Health Multilevel Intervention/s for Racial Equity (MIRACLE) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F(71)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: MEGHEA, CRISTIAN IOAN (contact)

PROJECT_TERMS: Active Learning;Address;Advocacy;Advocate;Area;Awareness;beneficiary;Birth;Birth Records;Black race;care systems;Caring;Clinical;clinical care;Communication;Communities;Community Health;Community Health Aides;Community Healthcare;community intervention;community setting;community-centered;comorbidity;Complement;Complex;cost effectiveness;cost-effectiveness evaluation;County;Data;Death Records;design;disparities in morbidity;Disparity;disparity reduction;early pregnancy;Education;Educational Curriculum;effectiveness evaluation;Effectiveness of Interventions;empowerment;Equity;evidence base;Face;health disparity;Health Services Accessibility;Health system;Hearing;Hispanic;Home visitation;Hypertension;Individual;Information Systems;Infrastructure;innovation;Intervention;intervention effect;Knowledge;Learning;Link;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Mental Health;Methods;Michigan;Modeling;mortality;mortality disparity;multiple chronic conditions;Not Hispanic or Latino;Nurses;Outcome;Participant;Patients;Perinatal;Persons;Policies;Population;Populations at Risk;postnatal;Postpartum Period;pragmatic trial;Pregnancy;pregnant;prenatal;programs;Provider;provider factors;Quality of Care;Quasi-experiment;Racial Equity;racism;Recording of previous events;Reporting;Research;Science;severe maternal morbidity;skills;Social Conditions;Social Workers;Standardization;Structural Racism;System;Testing;testing access;Training;treatment as usual;Work

PROJECT_TITLE: Multilevel community-centered intervention to reduce pregnancy related and associated morbidity and mortality (PRAMM) disparities in Non-Hispanic Black and Hispanic Medicaid-insured individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Genetic studies of tobacco and alcohol use, which are of great public health importance, have identified thousands of associated loci that can be used to predict substance use behaviors through polygenic risk scores. The proposed project leverages genetic data from >5 million individuals to improve the polygenic prediction of substance use, and to make this predictive utility applicable to all individuals across populations. Increasing genomic prediction accuracy allows for greater understanding of the genetic architecture of substance use and has substantial implications for the prevention and treatment of substance use, as well as important ethical, legal, and social implications.

PI_NAMEs: SAUNDERS, GRETCHEN  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Adoption;Affect;African;Alcohol consumption;Alcohols;All of Us Research Program;American;Award;Behavior;Behavioral Genetics;biobank;Bioethics;career;Clinical;cohort;Complex;cost;Coupled;Data;Data Discovery;Data Set;Demographic Factors;disorder risk;Distant;Drug Addiction;Drug usage;drug use behavior;East Asian;effective therapy;Equity;ethical, legal, and social implication;European;European ancestry;Exclusion;exome;functional genomics;Gene Expression;Gene Frequency;Genes;Genetic;genetic architecture;genetic association;Genetic Research;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genomic predictors;Genomics;Genotype;Goals;Health Care Costs;health disparity;Heritability;Heterogeneity;Human;improved;Individual;individualized prevention;instrument;interest;Life Style;Linkage Disequilibrium;Medical;Mental disorders;Mentors;Mentorship;Meta-Analysis;Methods;Modeling;National Institute of Drug Abuse;nicotine use;Participant;Performance;Persons;Phenotype;polygenic risk score;Population;Population Genetics;portability;precision medicine;preventable death;Prevention;Psychology;Public Health;rare variant;Research;Risk;risk prediction;risk stratification;Sample Size;Sampling;Scientist;screening;Siblings;Smoking;Source;statistics;Structure;Substance of Abuse;substance use;substance use treatment;Technology;Tobacco;Tobacco use;Training;trait;Trans-Omics for Precision Medicine;United States;Variant;Veterans;whole genome;Work

PROJECT_TITLE: Improving cross ancestry polygenic prediction of tobacco and alcohol use

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Glaucoma is the leading cause of irreversible blindness worldwide, whose defining characteristic is the loss of neurons that connect the eye to the brain. Microglia, the resident immune cells of the nervous system, have emerged as important contributors to neuronal death in glaucoma. In this proposal we will investigate how microglia cause inflammation and neuron loss in glaucoma, with the hope of ultimately developing novel neuroprotective treatments for this common blinding disease.

PI_NAMEs: MARGETA, MILICA  (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Animal Model;Animals;Apolipoprotein E;apolipoprotein E-3;Apoptotic;Aqueous Humor;Autoimmune;Autopsy;Binding;blind;Blindness;Brain;Cause of Death;Cell Culture Techniques;Cell Death;cell injury;Cell Survival;Cells;Characteristics;common treatment;Complement;conditional knockout;cytokine;Data;Data Set;Demyelinations;Development;Disease;efficacy evaluation;Eye;Galectin 3;Genes;Genetic;Glaucoma;glial activation;Goals;high intraocular pressure;Human;Immune;Immunoglobulin Fragments;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injections;Interleukins;Macrophage;Mediating;Mediator;Membrane;Mental Depression;Microglia;Microspheres;Modeling;modifiable risk;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuroprotection;neutralizing antibody;novel;NR0B2 gene;Optic Nerve;Pathogenesis;Patients;peripheral nerve regeneration;pharmacologic;Phenotype;phosphatidylserine receptor;Phosphoric Monoester Hydrolases;Physiologic Intraocular Pressure;PIK3CG gene;Play;Prevalence;prevent;PTPN11 gene;receptor;recruit;Regulation;Reporter;Research;response;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Role;sensor;Signal Pathway;Signal Transduction;Therapeutic;transcriptome sequencing;translational approach;Up-Regulation;Visual impairment;Work

PROJECT_TITLE: Mechanisms of microglial neuroinflammatory response in glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: ONDERSMA, STEVEN J. (contact)

PROJECT_TERMS: Abnormal coordination;Address;Adopted;antenatal;antenatal care;Awareness;Behavioral;Birth;Birth Records;Black Populations;Black race;brief motivational intervention;Cessation of life;checkup examination;Clinic;cluster randomized design;Collaborations;Color;Communities;community engaged approach;Community Health Aides;community partners;community-level factor;cost effective;cost effectiveness;Country;Data;Data Set;design;Development;digital;digital intervention;disparities in morbidity;Disparity;Early identification;efficacy testing;Elements;Enrollment;Ensure;Family member;Feedback;flexibility;Geography;Health;health care settings;Health Personnel;Health Services Accessibility;Home visitation;implicit bias;improved;Income;indexing;Individual;ineffective therapies;innovation;Intervention;Knowledge;Life Style;Link;Manuals;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediation;Medicaid;Mental Depression;Mental Health;Michigan;Morbidity - disease rate;mortality;mortality disparity;mortality risk;Not Hispanic or Latino;novel;open source;Outcome;Participant;partner violence;Patients;people of color;Persons;Postpartum Period;Pregnancy;Pregnancy Rate;pregnant;Primary Care;primary outcome;Privatization;programs;Provider;provider communication;provider factors;Racial Equity;randomized trial;Recommendation;Research;Research Personnel;residence;Resources;Risk;Risk Factors;Rural;rural area;Sampling;scale up;screening;secondary outcome;Secure;service providers;Services;Site;social;social stigma;Social support;Structure;substance use;Support System;Symptoms;Technology;Text;Translating;underserved rural area;urban area;urban residence

PROJECT_TITLE: High reach, multi-level digital intervention for Pregnancy-Related and -Associated Morbidity and Mortality (PRAMM) Disparities


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH High fidelity, longitudinal follow-up using the ECHO protocol will continue on an existing cohort of 881 children, 491 mothers, and 317 UCP fathers from 493 families in Utah while enrolling up to 600 couples planning pregnancy or pregnant people into the study. New and existing local and national data will be used to investigate the impact of potentially modifiable environmental exposures such as indoor air quality on perinatal and child health outcomes such as pregnancy complications and asthma. Data from multiple types of exposure assessment will be evaluated as mixtures to better understand the impact of environmental exposures as they are experienced rather than as individual exposures.

PI_NAMEs: PORUCZNIK, CHRISTINA ;STANFORD, JOSEPH BARNEY (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Accounting;Address;Air;air monitoring;Air Pollutants;Air Pollution;Area;Asthma;Biological;Birth;Breast Feeding;Bronchiolitis;Characteristics;Chemical Exposure;Child;Child Development;Child Health;Childhood;cohort;Collaborations;Communities;Complex;Conceptions;Consent;County;Couples;Data;Data Collection;Data Element;Demographic Factors;Development;Dimensions;Disease;DNA;Endocrine Disruptors;Enrollment;Environment;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Risk Factor;epigenome;Etiology;experience;Family;Fathers;Fertility;Fertilization;follow-up;Future;Genome;Genomics;Geography;Goals;Health;Hispanic;hispanic community;Home;Housing;implantation;Individual;Indoor Air Quality;indoor concentrations;infertility treatment;Inherited;innovation;Link;Measurement;Measures;Mediating;Metabolic;microbiome;Minority Groups;Modeling;Mothers;multiple data types;Native Hawaiian or Other Pacific Islander;offspring;Outcome;Ozone;Pacific Islander;Paper;Parents;Participant;Particulate Matter;Pathway interactions;Perinatal;perinatal outcomes;Persons;Phase;Phenols;phthalates;Planned Pregnancy;pollutant;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Premature Birth;prenatal;Process;Proteome;Protocols documentation;Public Health;Publishing;recruit;reproductive outcome;Research;response;Risk;Sampling;Science;sensor;Site;social factors;Sodium Chloride;Spontaneous abortion;subfertility;success;Time;time-to-pregnancy;Underrepresented Minority;urinary;Utah;volatile organic compound;Woman;Work;Writing

PROJECT_TITLE: Utah Children's Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  This project will identify new mechanisms by which the brain influences energy balance through energy expenditure. We will focus on a ventromedial hypothalamic neuropeptide and the mechanisms that it engages within downstream brain regions. We will determine the signals that necessitate this neuropeptide signal, where neuropeptide action is required, and reveal the cells and mechanisms engaged in peripheral target adipose and muscle tissues.

PI_NAMEs: FLAK, JONATHAN NICHOLAS (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adipose tissue;Affect;Agonist;Anatomy;Anterior;Area;bariatric surgery;Body Weight;Body Weight decreased;Brain;Brain region;Brain Stem;Cell Communication;Cells;cellular targeting;Communication;cost;Cost of Illness;counterregulation;Country;Data;Death Rate;Development;Diabetes Mellitus;Diet;dietary;Eating;Electrophysiology (science);energy balance;Energy Metabolism;exhaust;experimental study;Fasting;Fatty acid glycerol esters;Fiber;gamma-Aminobutyric Acid;GCG gene;Genes;Genetic;Goals;Homeostasis;Hypoglycemia;Hypothalamic structure;Individual;inhibitory neuron;Injections;Leptin;loss of function;Medial;Mediating;Metabolic;Metabolic Diseases;Midbrain structure;Morbidity - disease rate;mouse model;Mus;Muscle;neural circuit;neuromechanism;Neurons;Neuropeptide Receptor;Neuropeptides;new therapeutic target;Normal Range;novel;novel therapeutics;Nutrient;Obesity;Obesity associated disease;obesity treatment;Organ;Outcome;Output;Paper;Patients;Peripheral;Persons;pituitary adenylate cyclase activating polypeptide;Preoptic Areas;Process;Publishing;receptor;recombinase;Research;response;Role;side effect;Signal Transduction;Site;Structure of paraventricular nucleus of thalamus;Structure of terminal stria nuclei of preoptic region;System;Testing;Thermogenesis;Tissues;United States;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: Defining the neurocircuit activated by the VMH to control energy expenditure.

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative Aging is the cause of most human disease, including heart disease, neurodegeneration, and cancer. Chemicals, diets, and genetic interventions have been developed to extend organismal lifespan and health span, yet we have very limited knowledge of the molecular mechanisms at play. The proposed work seeks to identify ultimate molecular targets of lifespan extending interventions, that work in all species tested, during yeast replicative aging.

PI_NAMEs: TYLER, JESSICA K (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acidity;Age;Aging;anti aging;Autophagocytosis;biological adaptation to stress;Caloric Restriction;Cell Nucleolus;Cells;Chemicals;Chronology;cofactor;Coupled;Data;Defect;Dietary Intervention;DNA;DNA biosynthesis;DNA Repair;DNA Repair Gene;DNA replication origin;drivers of aging;Exclusion;extend lifespan;Fire - disasters;gene therapy;genetic manipulation;Genome;Genome Stability;Genomic Instability;gerotherapeutic;Goals;healthspan;Heart Diseases;Histones;human disease;improved;Intervention;Iron;Knowledge;Length;life span;Loss of Heterozygosity;Maintenance;Malignant Neoplasms;Metformin;Microfluidics;Modeling;Molecular;Molecular Genetics;Molecular Target;Mus;Nerve Degeneration;new therapeutic target;Organism;overexpression;Pathway interactions;Pharmaceutical Preparations;Play;prevent;pro-aging;Production;Proteins;Regulation;repaired;response;Ribosomal DNA;Ribosomes;Saccharomyces cerevisiae;Saccharomycetales;single cell analysis;Sirolimus;Sirtuins;Stress;Sulfur;System;Testing;Time;Up-Regulation;Vacuole;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Discovering how autophagy is sufficient to extend yeast replicative lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: JOHNSON, JENNIFER E (contact)

PROJECT_TERMS: Address;African American;American;Awareness;Birth;Birth Records;Caring;Charge;Chronic;Communities;community center;Community Health;Community Healthcare;community partners;community setting;cost;cost effectiveness;County;Data;Data Set;Death Records;design;disparities in morbidity;Disparity;effectiveness evaluation;Effectiveness of Interventions;Elements;Equity;evidence based guidelines;Evidence based practice;experience;Face;Goals;Health;Health Benefit;health equity;Health system;Hispanic;Hospitals;implementation cost;implementation intervention;implementation outcomes;implementation science;implementation trial;improved;Individual;innovation;Intervention;intimate partner violence;Investments;Lead;Link;Maintenance;Manuals;Maternal Health;maternal morbidity;Maternal Mortality;maternal safety;Medicaid;meetings;Mental Health;Michigan;Morbidity - disease rate;mortality;mortality disparity;Mothers;Not Hispanic or Latino;obstetric care;Outcome;Outpatients;Penetration;Persons;Policies;Population;postpartum care;Postpartum Period;Pregnancy;pregnancy related death;pregnant;programs;Provider;Racial Equity;Research;Safety;Sampling;scale up;Science;Services;severe maternal morbidity;Surveys;Testing;Time;United States National Institutes of Health;Women's Health;Work

PROJECT_TITLE: Scale-up implementation approaches to ending pregnancy related and associated morbidity and mortality (PRAMM) disparities


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Subarachnoid hemorrhage (SAH) is estimated to account for 25% of all cerebrovascular disease-related deaths and has a survivability rate of only 50% within 30 days of the initial event due to delayed cerebral ischemia (DCI). All clinical trials for treatment of DCI have been unsuccessful because promising therapies in preclinical models have all failed to translate to humans. The overall goals of this research are to 1) validate the lumen-perfusable, vascularized, microfluidic model system using ex vivo human brain tissue that fully recapitulates the complex multi-cellular hierarchy and cell interactions required to sufficiently model SAH and DCI and 2) develop, characterize, and assess the neuroprotective efficacy of a novel dual-targeted nanoparticle therapeutic after inducing an SAH and DCI event in the vascularized microfluidic model.

PI_NAMEs: O'GRADY, BRIAN J (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;3D Print;Ablation;Address;Affect;Age;Anatomy;Aneurysmal Subarachnoid Hemorrhages;Animal Model;Animals;Anticoagulants;Antioxidants;arteriole;Astrocytes;barrier to testing;Biological Models;Biology;Biomimetics;Blast Injuries;Blood;Blood - brain barrier anatomy;blood perfusion;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain Aneurysms;Brain Pathology;brain tissue;Cell Communication;Cell Culture Techniques;Cell Death;Cell Physiology;Cells;Cerebral Ischemia;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cessation of life;Clinical Treatment;Clinical Trials;Coculture Techniques;Complex;Data;deprivation;design;Development;Devices;Dextrans;drug discovery;Drug Kinetics;drug release profile;Drug Targeting;effective therapy;Endothelial Cells;Endothelium;Engineering;Ensure;Equipment;Event;experience;Extracellular Matrix;Extravasation;fabrication;Failure;Foundations;functional outcomes;fundamental research;Future;Glucose;Goals;Growth;Hemorrhage;Hemorrhagic Disorders;Heparin;Human;human model;Hydrogels;improved;improved outcome;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Intervention;Ischemia;Knowledge;Label;Life;Long-Term Effects;Macrophage;Managed Care;manufacture;Measures;Mentors;Microfluidic Microchips;Microfluidics;Modeling;nanoparticle;nanoparticle delivery;neovascularization;Nervous System Disorder;neural;Neuroglia;neuron loss;Neurons;neuroprotection;neurovascular;neurovascular unit;novel;novel therapeutics;Optic Nerve;Oxygen;Pathology;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Physiological;Physiology;Polymers;Pre-Clinical Model;Production;Property;propylene;protective efficacy;Quality of life;Reactive Oxygen Species;Reproducibility;Research;Research Personnel;response;Running;Rupture;screening;spatiotemporal;Stroke;stroke event;stroke-like episode;Structure;Subarachnoid Hemorrhage;success;Sulfides;System;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapeutic development;therapeutic nanoparticles;Thrombosis;Tight Junctions;Tissue Engineering;Tissues;Toxic effect;Training;Translating;Vascularization;vasogenic edema;Vasospasm;Work

PROJECT_TITLE: Development of a 3D neurovascular unit for in vitro modeling of subarachnoid hemorrhage and screening therapies


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Explicating modifiable environmental risk and resiliency factors related to early indicators of behavioral problems so that interventions can be applied early to promote optimal development will have implications for preventing psychopathology, such as depression and anxiety. Leveraging ECHO's longitudinal design with assessments over vulnerable developmental windows, combined with its large sample size, diverse geography, diverse population characteristics, and broad exposure assessment, this proposal will partner with the greater ECHO program to drive an exponential increase in our understanding of neurodevelopmental risk patterns that presage psychopathology in youth, providing particular insight into etiologies related to complex environmental mixtures. The longitudinal design also can provide insight into how and when to optimally intervene (nutrition, policy, exposure reduction) to reduce risk.

PI_NAMEs: CARROLL, KECIA NICOLE;WRIGHT, ROBERT O;WRIGHT, ROSALIND J (contact)

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: 20 year old;Adolescence;Affect;Age;Air Pollutants;Anxiety;Anxiety Disorders;Arousal;Attention;Award;Biogenesis;Central Nervous System;Chemicals;Child;Childhood;cognitive control;cognitive system;cohort;Color;Communities;comorbidity;Complex;Complex Mixtures;Conceptions;Data;Depressive disorder;design;Development;Diagnostic;Dimensions;Disease;Dose;Early identification;effective intervention;emotion regulation;Enrollment;Environment;environmental chemical;Environmental Risk Factor;Ethnic Origin;Etiology;Exposure to;fine particles;Funding;Future;Genes;Geography;Grant;Health;health equity;health inequalities;high dimensionality;in utero;infancy;Infrastructure;insight;Intervention;Joints;lens;Life;Life Cycle Stages;Link;longitudinal design;maternal stress;Measures;Mediator;Mental Depression;Metals;Methodology;Methods;Micronutrients;Modeling;Mood Disorders;Mothers;Negative Valence;neurobehavioral;Nitrogen Dioxide;novel;nutrition;Nutrition Surveys;Nutritional;Obesity;Outcome;Ozone;Participant;Pathway interactions;Pattern;Perinatal;perinatal environment;Persons;physical conditioning;Pilot Projects;Policies;Population;Population Characteristics;Population Heterogeneity;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal stress;prevent;Problem behavior;Process;programs;psychological stressor;Psychopathology;Psychosocial Factor;Quality of life;Race;recruit;Regulation;remote sensing;Research;Research Domain Criteria;Research Personnel;resilience factor;respiratory;Risk;Risk Factors;Risk Reduction;Role;Sample Size;Sampling;Science;segregation;sex;Site;social stressor;Statistical Methods;statistics;Stress;Symptoms;System;theories;Toxin;Woman;Work;Youth

PROJECT_TITLE: Mount Sinai ECHO site for Perinatal  Environment and Development Studies


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: SIOUX FALLS

ORG_NAME: AVERA MCKENNAN

ORG_STATE: SD

PHR: PROJECT NARRATIVE This proposal serves to expand knowledge on prenatal stress and life events and it’s later effect on child obesity and development, with particular emphasis on how nutrition impacts these relationships. PASS ECHO is based in South Dakota and brings geographical diversity to ECHO, including a large number of rural participants, as well as a significant number of American Indian participants. During Phase I, 6,647 mother child pairs were enrolled in PASS ECHO and we are proposing an additional 1,650 new prenatal recruits.

PI_NAMEs: ELLIOTT, AMY J (contact);HOCKETT, CHRISTINE W

PROJECT_TERMS: Adipose tissue;Adolescence;Adult;Agreement;allostatic load;American Indians;Biological Markers;Body Composition;Body mass index;Body measure procedure;built environment;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cheyenne;Child;Child Development;Child Health;Chronic stress;cohort;Collaborations;Communities;Conceptions;Consent;Coronary heart disease;Data;data sharing;design;Development;Diabetes Mellitus;Disease;Dual-Energy X-Ray Absorptiometry;Dyslipidemias;early childhood;Eating Behavior;Economics;Education;Enrollment;Ethnic Population;Event;executive function;Exposure to;Fatty acid glycerol esters;Feeding behaviors;Female;follow-up;food security;Foundations;Geography;Gestational Diabetes;Health;Healthy Eating;Individual;Infant;Inflammatory;Insulin Resistance;Joints;Knowledge;Late Effects;Leadership;Life;Life Style;male;maternal obesity;Measures;Mediating;Mental Depression;Metabolic;microbiome composition;middle childhood;mortality;Mothers;Navajo;Neighborhoods;neurodevelopment;Neurosecretory Systems;Northern Plains;nutrition;Obesity;obesity in children;offspring;OGTT;Outcome;Outcome Measure;Participant;participant enrollment;Patients;Pattern;Personal Satisfaction;Phase;Physiological;Policies;Pregnancy;prenatal;prenatal stress;Protocols documentation;Psyche structure;racial diversity;racial population;recruit;Research;Research Infrastructure;Risk;Risk Factors;Roentgen Rays;Rural;rural area;Rural Community;Science;secondary analysis;sex as a biological variable;Sioux Indians;social health determinants;South Dakota;subcutaneous;success;Tribes;United States National Institutes of Health;Visceral

PROJECT_TITLE: Environmental influences on Child Health Outcomes in the Northern Plains PASS-ECHO Cohort


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: KEY, KENT DARNELL (contact)

PROJECT_TERMS: Advisory Committees;American Public Health Association;Articulation;Birth;Collaborations;Communication;Communities;community academic partnership;community based participatory research;community engaged research;community engagement;Community Health Aides;community organizations;community partners;community partnership;conflict resolution;Coronavirus;culturally appropriate intervention;Dedications;Disparity;dissemination science;Doctor of Philosophy;Ensure;Equity;Evaluation;expectation;experience;Family;Foundations;Goals;Government;Health;Health Disparities Research;health disparity;health equity;Health equity research;Health system;Healthcare;Heart;implementation science;improved;Information Dissemination;Intervention;Lead;Leadership;Learning;Maternal Health;Maternal health equity;member;Michigan;novel;operation;Ownership;Persons;Policies;Policy Maker;Process;Productivity;programs;Public Health;Public Policy;racial disparity;Racial Equity;racism;Research;Research Personnel;Research Project Grants;Resources;Role;scale up;Science;shared decision making;skills;synergism;System;theories;Translating;Trust;United States National Institutes of Health;Universities;uptake;Vision

PROJECT_TITLE: Community Partnership Consortium


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: OVERALL PROJECT NARRATIVE The broad goal of the New York Community-Hospital-Academic Maternal Health Equity Partnerships (NY- CHAMP) is to launch a novel community-centered research, training, and engagement program that will identify and address the comorbid biologic and psychologic pathways linking adverse social determinants of health to disparities in severe maternal morbidity and mortality (SMM/MM); and with our partners, co-design scalable multi-level strategies grounded in anti-racism and empowerment to reduce SMM/MM and affect systems and policy change for maternal health equity in New York City and State. NY-CHAMP brings together Columbia University, Weill Cornell Medicine, four lead community organizations, and a broad coalition of community, hospital, academic, and government partners in a highly collaborative, paradigm-shifting model for excellence in maternal health research.

PI_NAMEs: BROWN, SEVONNA ;DORVAL-MOLLER, MADELEINE ;HALL, KELLI STIDHAM;OSBORNE, LAUREN M;REDDY, UMA  (contact);RODRIGUEZ, EMILIE ;SAFFORD, MONIKA M;ST. CLAIR, VICTORIA ;TAYLOR, JACQUELYN Y

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: access disparities;Accounting;Address;Affect;anti-racism;Artificial Intelligence;Asian;Biological;Birth;Black Populations;Black race;black women;cardiovascular health;Cardiovascular system;care delivery;career development;Caribbean region;Caring;Centers of Research Excellence;Cities;Clinical Decision Support Systems;Cognitive Therapy;Collaborations;Communities;community engaged research;community engagement;Community Healthcare;Community Hospitals;community organizations;community partnership;community-centered;comorbidity;cost;Data;design;disability;Disparity;Ecosystem;effectiveness/implementation trial;Electronic Health Record;empowerment;Ensure;Equity;equity, diversity, and inclusion;Evaluation;evidence base;experience;Goals;Government;Government Agencies;Health care facility;health care service utilization;health disparity;health inequalities;Health Sciences;Health system;Healthcare;Hispanic;Hospitalization;Hospitals;Individual;Inequity;Infrastructure;Institution;Intervention;Justice;Knowledge;Lead;Leadership;Link;Maternal Health;Maternal health equity;Maternal Health Services;Maternal Mortality;Medicaid eligibility;Medical center;Medicine;member;Mental Health;Methods;Modeling;New York;New York City;novel;Outcome;Pathway interactions;Patient Education;patient oriented;Patient-Centered Care;Patients;Perinatal;Persons;pilot test;Policies;Postpartum Period;pregnancy related death;Prevalence;Process;programs;Provider;psychologic;Race;Research;research data dissemination;Research Personnel;Resources;response;risk prediction model;Rural;Science;Service delivery model;Services;severe maternal morbidity;Site;social health determinants;Sterile coverings;Structural Racism;Structure;System;Test Result;Time;Training;training opportunity;Training Programs;Trauma;United States National Institutes of Health;Universities;Vision;Women's Health;Work

PROJECT_TITLE: NY Community-Hospital-Academic Maternal Health Equity Partnerships (NY-CHAMP)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: OSBORNE, LAUREN M (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Advocacy;Age;allostatic load;attentional control;Behavior Therapy;Behavioral;behavioral health intervention;Birth;Black race;Breast Feeding;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caribbean region;Caring;Client satisfaction;Clinical;Cognitive;Cognitive Therapy;Collaborations;Communities;Community Health Aides;Community Hospitals;community partners;comorbidity;Competence;Complex;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data;Detection;Dimensions;Disadvantaged;E-learning;Ecosystem;effectiveness evaluation;effectiveness measure;effectiveness testing;Electronic Health Record;Emergency Situation;empowerment;ethnic minority;Event;evidence base;Evidence based intervention;experience;Focus Groups;Goals;Health;health care service utilization;health equity;Health Personnel;Health system;Healthcare;Home Blood Pressure Monitoring;Hospital Administrators;hospital services;Hospitals;Hybrids;implementation framework;implementation outcomes;implementation process;implementation strategy;implementation trial;improved;Incidence;Individual;Infrastructure;innovation;integrated care;Intervention;intervention participants;intervention refinement;Interview;intrapartum;Learning;Life;Low income;Maternal Health;Maternal health equity;Maternal Mortality;Measures;Medical;Mental Health;Methods;New York;New York City;novel;Overdose;Parents;Participant;Patients;perceived stress;Perinatal;Personal Satisfaction;Persons;physical conditioning;Physiological;policy implication;Population;postpartum care;Postpartum Depression;postpartum health;postpartum outcome;Postpartum Period;Pregnancy;prevent;primary outcome;Process Measure;programs;Provider;Psyche structure;Quality of Care;Quality of life;Questionnaires;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research Personnel;resilience;Resources;Risk;satisfaction;scale up;Services;Site;social;Social support;substance use;Suicide;Surveys;System;Telephone;Testing;theories;Thinking;Training;training opportunity;Trauma;treatment arm;Update;Visit;Women's Health;Work

PROJECT_TITLE: Living Healthy for Moms


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: MARGERISON, CLAIRE E (contact)

PROJECT_TERMS: Active Learning;Address;Affect;Behavioral;Biological;Black race;cohort;Collaborations;college;Communities;community engaged research;community partners;community partnership;Data;design;Development;disparities in morbidity;Disparity;disparity reduction;dissemination science;Environment;Environmental Risk Factor;experience;Faculty;Family;Funding;Goals;Health;health disparity;Health Sciences;Health system;Hispanic;Human;implementation science;indigenous community;Inequity;Insurance Claim Review;Interdisciplinary Study;interest;Intervention;Knowledge;Learning;Location;Maternal Health;Maternal health equity;Medicaid eligibility;Medicine;mentoring community;Mentors;mHealth;Michigan;Morbidity - disease rate;mortality;mortality disparity;Mothers;partner violence;Patients;Phase;Policies;Population Analysis;Postdoctoral Fellow;Pregnancy;Provider;Quasi-experiment;Racial Equity;randomized trial;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Role;Rural Community;rural setting;Scientist;severe maternal morbidity;sociocultural determinant;Source;structural determinants;Structure;Students;substance use;Suicide;synergism;System;Testing;Training;training opportunity;Training Programs;Training Support;Translating;trial design;United States National Institutes of Health;Universities;urban setting;Work

PROJECT_TITLE: Training program addressing the multilevel factors that affect pregnancy-related and pregnancy-associated morbidity and mortality disparities


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Indigenous mothers have the highest rates of maternal mortality and morbidity in the U.S. The primary objective of this U54 application is to establish a successful and self-sustaining Center for Indigenous Resilience, Culture, and Maternal Health Equity (CIRCLE) to understand and intervene to improve Indigenous maternal health. We will collaborate and work closely with other Maternal Health Research Centers of Excellence, Implementation Science Hub, and Innovative Data and Coordination Hub to provide insights on root causes and translational opportunities with the long-term goal of reducing Indigenous maternal mortality and morbidity and promoting maternal health equity.

PI_NAMEs: FRIEDMAN, JACOB E;SHREFFLER, KARINA M. (contact);SPICER, PAUL G;VANWAGONER, TIMOTHY M

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Alaska Native;American Indians;Amniotic Fluid Embolism;Anthropology;Autoimmune Diseases;Automobile Driving;base;Behavioral;biobehavior;Bioinformatics;Biological;Biometry;Birth;Blood Vessels;Cardiac;cardiometabolism;career;Centers of Research Excellence;Cessation of life;Chronic stress;Collaborations;Collagen;Communities;community based participatory research;community partners;community partnership;Conceptions;Continuity of Patient Care;Coronary;Country;cultural health;Data;Death Rate;Discipline of Nursing;Discipline of obstetrics;disparities in morbidity;disparity elimination;Ensure;Epidemiology;Equity;Ethics;experience;Family;Food;food insecurity;Foundations;Funding;Future;Goals;Gynecology;Health;health disparity;Health equity research;health inequalities;Health system;Hemorrhage;high risk;Homicide;Human Development;Immunology;implementation science;improved;Indigenous;indigenous community;Individual;Inequity;Infection;Injury;innovation;insight;intergenerational;Interruption;Intervention;intimate partner violence;Knowledge;Label;Leadership;Life;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal outcome;maternal wellbeing;Maternal-fetal medicine;Medical;member;Mental Health;Mission;mortality;Mothers;Native Americans;Not Hispanic or Latino;Nursing Care Management;nutrition;Obesity;Oklahoma;Outcome;Outcomes Research;Pathway interactions;Patient-Focused Outcomes;Physiology;Population;postpartum care;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnancy related death;prenatal;Process;Public Health;public health priorities;Race;Recommendation;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;Research Training;resilience;Resources;Role;Rural;Sampling;Self Care;severe maternal morbidity;social;Sociology;Source;Substance Use Disorder;Suicide;synergism;Testing;Translating;translational potential;Translational Research;Trauma;tribal community;tribal health;tribal leader;tribal member;tribal organization;Tribes;United States;United States National Institutes of Health;White Women;Woman;Women's Health;Work


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PI_NAMEs: JONES, EMILY JEAN (contact);WETHERILL, MARIANNA

PROJECT_TERMS: Acculturation;Address;adverse childhood events;Affect;Alaska Native;Alaska Native Women;American Indians;Behavior;Behavioral;Biological;Biological Markers;Birth;cardiometabolic risk;cardiometabolism;care giving burden;care providers;Child;Childbirth;Chronic;Collaborations;Communities;community engagement;Community Health;Community Healthcare;comorbidity;comparison group;cultural health;Data;Decision Making;design;Diabetes Mellitus;Diagnosis;Diet;dietary;Dietary intake;dietary manipulation;Discrimination;Disparity;Educational Curriculum;Ensure;Equation;Equity;Evaluation;Excision;experience;Family;Feedback;Female of child bearing age;Focus Groups;follow-up;Food;food insecurity;food security;gender-based violence;Gestational Diabetes;gestational weight gain;Glycosylated hemoglobin A;group intervention;Group Interviews;Health;health care availability;health care service utilization;Health Food;health inequalities;Health Personnel;Healthcare;High Prevalence;high risk;High-Risk Pregnancy;Home;Homicide;Household;Hypertension;Immune;Indigenous;indigenous community;Inflammation;Influentials;intergenerational;Intervention;Interview;intimate partner violence;Involuntary Sterilization;Kansas;Lactation consultant;Life Cycle Stages;Link;Live Birth;Managed Care;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;maternal safety;maternal stress;maternal wellbeing;Measures;Medicine;Midwife;Modeling;Morbidity - disease rate;motherhood;Mothers;Native Americans;Needs Assessment;Nutrient;nutrition;Nutrition Assessment;Nutritional;Obesity;Observational Study;Oklahoma;Outcome;parous;Participant;Pathway interactions;Pattern;perceived stress;Perinatal;Personal Satisfaction;Physical activity;Population;Postpartum Depression;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnant;Premature Birth;Prenatal care;prepregnancy;Prevalence;Prevention;primary outcome;Provider;Randomized;Recording of previous events;recruit;Reporting;Research;Research Design;resilience;Risk;Risk Behaviors;Risk Factors;rural area;secondary outcome;Security;Self Care;Self-Injurious Behavior;Series;severe maternal morbidity;Sleep;social;social health determinants;Social support;Source;Stress;stress management;stress reduction;Stressful Event;structural determinants;substance use;Suicide;Support System;Surveys;Testing;Texas;theories;Trauma;tribal community;tribal health;Tribes;Victimization;Violence;Well in self;whole health;Woman

PROJECT_TITLE: Food for LifecOURse equity In maternal Security and Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Women's Health Research

PI_NAMEs: LI, GUOHUA  (contact)

PROJECT_TERMS: Address;Automobile Driving;Birth;Black race;black/white disparity;career development;Caring;Childbirth;Cities;Communities;community engagement;Community Hospitals;community organizations;cost estimate;Country;County;Data;data modeling;Development;Dimensions;disparities in morbidity;Disparity;Disparity population;disparity reduction;Education;Effectiveness;Employment;Ensure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;Exclusion;Focus Groups;Health Care Costs;health data;health disparity;health equity promotion;health inequalities;Health Policy;Health system;Healthcare;Height;Hospital Administrators;Hospital Costs;Hospitals;Imprisonment;Improve Access;improved;Incidence;indexing;Inequity;insight;Institutional Practice;Intervention;intervention effect;Interview;Life Experience;Link;Lived experience;Maternal Health;Maternal health equity;Maternal Health Services;Maternal Mortality;maternal outcome;Measures;Medicaid;Medicaid eligibility;Methods;Morbidity - disease rate;mortality;mortality disparity;mortality risk;multilevel analysis;multiple data sources;New York City;Not Hispanic or Latino;Outcome;Patient-Centered Care;Patients;Persons;Play;Policies;Politics;Population;Postpartum Period;Pregnancy;Procedures;prospective;Public Policy;Race;racial determinant;racial disparity;racial minority;racial population;racism;Records;Research;Research Methodology;Research Project Grants;Research Technics;residence;residential segregation;Risk;Risk Factors;Role;safety net;Sampling;Science;segregation;severe maternal morbidity;Site;social determinants;societal costs;Sterile coverings;structural determinants;Structural Racism;Structure;suicidal;System;system-level barriers;Techniques;Testing;theories;Translating;United States National Institutes of Health;Urban Hospitals;Washington;Work

PROJECT_TITLE: Policy solutions for addressing structural racism in maternal health disparities


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Rural Health;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE The COVID-19 pandemic exposed deficiencies in communication between intensive care unit (ICU) clinicians and family members and shed light on how social determinants of health (such as education/healthcare access, economic stability, and neighborhood environment) inequitably impact underrepresented populations (such as rural, Black, and Hispanic communities). This project will collect data to examine how communication quality, healthcare distrust, social determinants of health, personality traits, and other factors play a role in how communication unfolds in the ICU and their impact on patient- and family-centered care. When the research is completed, we will have a better understanding of how these factors impact health outcomes that will help us to develop and tailor interventions that address these issues and may improve the relationship between clinicians and patients/families as well as patient- and family- centered outcomes.

PI_NAMEs: SCOTT, ALLISON M;VAN SCOY, LAUREN JODI (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Affect;Anxiety;Attention;Black race;Caring;Clinical;Communication;COVID-19 pandemic;Data;Decision Making;demographics;design;Disparity;distrust;Economic Conditions;Economics;Education;Environment;experience;Family;Family member;Future;Goals;Health;health care availability;Health education;Health Professional;Healthcare;hispanic community;improved;Individual;innovation;Intensive Care Units;Intervention;Intrinsic factor;Knowledge;Length of Stay;Longitudinal, observational study;Measures;Mediating;Mediation;meetings;Mental Depression;Modeling;Neighborhoods;Outcome;outcome disparities;pandemic disease;Pathway interactions;patient oriented;Patient-Focused Outcomes;Patients;Perception;Personality Traits;post-pandemic;Post-Traumatic Stress Disorders;post-traumatic symptoms;programs;Protocols documentation;psychological outcomes;Psychological Stress;Questionnaires;Research;Risk;Rural;Rural Community;rural underrepresented;Severity of illness;shared decision making;Social Conditions;social health determinants;Stress;Testing;Therapeutic;trait;trial design;Trust;Underrepresented Populations;underserved community;Ventilator;Work

PROJECT_TITLE: Communication quality during family meetings in the intensive care unit: how does quality impact health outcomes?

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: Overall   Postpartum hemorrhage (PPH) is a leading cause of maternal death and severe maternal morbidity (SMM) and disproportionately affects socially marginalized groups. The goals of this center are to reduce PPH and associated SMM by targeting important precursors to PPH-related SMM and mortality: cesarean birth and iron deficiency anemia (IDA). We propose a research agenda that includes scalable interventions that will lead to sustainable declines in all of these outcomes and realization of maternal health equity.

PI_NAMEs: CARMICHAEL, SUZAN L;EL-SAYED, YASSER Y (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Affect;Anemia;antenatal;Asian;Asian population;Attention;Birth;Black Populations;Black race;California;Caring;Centers of Research Excellence;Cesarean section;Clinical;Collaborations;Communities;community academic partnership;community involvement;Complex;Diagnosis;Dimensions;Discipline;Discipline of obstetrics;Disparity;disparity elimination;disparity reduction;effective therapy;Emotional;Environment;Equity;ethnic disparity;Ethnic Origin;Evaluation;experience;Goals;health equity;Healthcare;Hemorrhage;High Prevalence;high risk;Hospitalization;Hospitals;improved;Incidence;Individual;Inequity;innovation;Intervention;intrapartum;Iron deficiency anemia;Latinx;Latinx population;Leadership;Life;Life Cycle Stages;Link;Location;marginalized population;Maternal Health;Maternal health equity;Maternal Mortality;Mental Health;Methods;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Native American population;Outcome;Patients;Persons;Play;Population;Population Heterogeneity;Positioning Attribute;post-traumatic stress;Post-Traumatic Stress Disorders;post-traumatic symptoms;Postpartum Depression;postpartum health;Postpartum Hemorrhage;Postpartum Period;Pregnancy;Prevalence;prevent;Prevention;Prevention strategy;prospective;Provider;Race;racial disparity;Research;Research Infrastructure;Rest;Risk;Risk Factors;Role;Science;severe maternal morbidity;social;social structure;Standardization;Training;training opportunity;Translating;treatment strategy;underserved area;Universities;Work

PROJECT_TITLE: Stanford PRIHSM: PReventing Inequities in Hemorrhage-related Severe Maternal Morbidity


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: SPICER, PAUL G (contact)

PROJECT_TERMS: Academia;career;Cherokee Nation;Chickasaw Nation;Clinical;Clinical Sciences;Communities;community engaged research;community engagement;Community Health Systems;community organizations;community partners;community partnership;cultural health;design;Development;Ensure;Ethics;experience;Faculty;Fostering;Foundations;Funding;Genomics;Goals;Grant;health equity;health organization;Healthcare;Healthcare Systems;improved;Indigenous;indigenous community;innovation;Institution;Institutional Policy;Institutional Practice;Institutionalization;Intervention;Investments;Leadership;Legal Status;Link;Maternal Health;Maternal health equity;maternal outcome;Mission;multidisciplinary;National Human Genome Research Institute;Oklahoma;operation;Outcome;Outcomes Research;Patient-Focused Outcomes;Postdoctoral Fellow;Productivity;protocol development;Protocols documentation;Public Health;Research;Research Personnel;resilience;Resources;Science;Series;Structure;student participation;System;Training;Translational Research;tribal community;tribal health;Tribes;Woman;Work

PROJECT_TITLE: Community Partnership and Engagement


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: HALL, KELLI STIDHAM (contact)

PROJECT_TERMS: Accountability;Address;Advocacy;anti-racism;Area;Award;barrier to care;Birth;black women;care delivery;career development;Caribbean region;Caring;Centers of Research Excellence;Cities;Collaborations;Communities;community based participatory research;community building;community engaged research;community engagement;Community Health;Community Health Systems;Community Hospitals;community organizations;community partnership;community research;County;cultural competence;design;Dimensions;Directories;disparity reduction;empowerment;Equity;equity, diversity, and inclusion;Family;Foundations;Goals;Government;Grant;Health;health equity;Health Personnel;Health Policy;Health Priorities;Healthcare;Healthcare Systems;Hospitals;human centered design;implicit bias;Infrastructure;innovation;insight;Institution;Intervention;Investments;Justice;Lead;Leadership;Learning;Link;Maps;Maternal Health;Maternal health equity;Maternal Health Services;maternal morbidity;Maternal Mortality;Medical center;Medicine;member;Methodology;Mission;Modeling;Needs Assessment;Neighborhoods;New York;New York City;novel;Patient Education;Patients;Perinatal;Persons;Policies;Principal Investigator;Process;Provider;Race;repository;Research;research data dissemination;Resources;Role;Rural;safety net;scaffold;severe maternal morbidity;Site;Strategic Planning;System;Time;Training;Training Programs;Translating;Trust;United States National Institutes of Health;Universities;virtual;Woman;Work

PROJECT_TITLE: NY-CHAMP Community Engagement & Policy Action Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Microbiome;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This longitudinal study will continue to investigate the mechanisms by which social disadvantage (family and neighborhood financial disadvantage) experienced beginning in utero and through middle childhood impacts brain development and risk for clinical mental disorders in a unique sample of children closely followed across multiple assessment waves since birth. We will test the hypothesis that social disadvantage adversely affects brain structure and function and increases risk for psychopathology through chronic inflammatory pathways also linked to differences in the gut microbiome. We will explore the effects of caregiver and family, peer, and school supports on this risk trajectory, testing the idea that high caregiver support reduces the negative influences of social disadvantage, altered immune biomarkers, and gut microbiome disruptions.

PI_NAMEs: LUBY, JOAN L. (contact);SMYSER, CHRISTOPHER DANIEL;WARNER, BARBARA B

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 2 year old;3 year old;Adverse effects;Affect;Age;Behavior;Behavioral;Biological;Birth;Brain;brain volume;Caregiver support;Caregivers;caregiving;Child;Childhood;Chronic;circulating biomarkers;Clinical;clinical risk;Cognitive;cognitive development;Collection;Communities;Crime;cytokine;Data;Data Collection;data repository;Development;Diagnosis;Diffusion;Disadvantaged;early childhood;early life adversity;effector T cell;Environment;experience;Exposure to;Extended Family;Family;Frequencies;Functional Magnetic Resonance Imaging;gut microbiome;Immune;Immunologic Markers;in utero;Induced Neurons;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Inflammatory Response;Interleukin-6;Investigation;Language;Life;Link;Lipopolysaccharides;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Meditation;Memory;mental disorder prevention;Mental disorders;Metabolic Pathway;microbiome;microbiome alteration;middle childhood;monocyte;multimodality;neighborhood safety;Neighborhoods;Neonatal;neurodevelopment;neuroinflammation;Neurons;novel;Parents;Pathway interactions;peer;peer support;Phase;Pregnancy;prenatal;Prevalence;Prevention;preventive intervention;prospective;Psychopathology;Reporting;repository;resilience;resilience factor;response;Risk;risk minimization;Role;Sampling;school environment;School-Age Population;Schools;social;social disparities;social influence;social relationships;social structure;Social support;spectrograph;Structure;Surface;Symptoms;systemic inflammatory response;Testing;Time;TNF gene;translational potential;Variant

PROJECT_TITLE: Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project aims to develop a scalable and transformative technology for simultaneous profiling of multi epigenomic modalities, whole transcriptome, and a panel of proteins at tissue scale and cellular level in a spatially resolved manner. It will be applied to brain lesions in multiple sclerosis to generate detailed spatial map of relevant cells, including interactions among them, and to identify cellular and molecular mechanisms operating in MS brain lesions. It will improve our understanding of the relationship between tissue organization, function, and gene regulatory networks in MS.

PI_NAMEs: DENG, YANXIANG  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Address;Affect;Area;axon injury;Bar Codes;Biochemistry;Biological Markers;biological systems;Biology;Brain;brain cell;brain tissue;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;CNS autoimmune disease;Coupled;Data;Degenerative Disorder;Demyelinations;Development;Disease;Dissociation;Environment;epigenomics;gene regulatory network;Genetic Transcription;healthspan;Heterogeneity;histone modification;Human;Immune;immune cell infiltrate;Immune response;Immune Targeting;improved;Inflammation;Inflammatory;Inflammatory Response;Knowledge;Lesion;life span;Maps;Mentorship;Messenger RNA;Methods;microdevice;Microfluidics;Modality;Molecular;Molecular Profiling;Motivation;multiple omics;Multiple Sclerosis;Multiple Sclerosis Lesions;Neighborhoods;Neuroglia;neuroinflammation;Neurologic;neuron loss;novel;novel therapeutic intervention;Outcome;Peripheral;Persons;Phenotype;Postdoctoral Fellow;Process;Progressive Disease;Proteins;Refractory;Relapse;repaired;Research;Resolution;Sampling;Scheme;Shapes;single cell genomics;success;Suspensions;targeted treatment;Technology;Testing;Time;Tissues;tool;trafficking;transcriptome;white matter;Work

PROJECT_TITLE: High-spatial-resolution multi-omics sequencing of brain lesions in multiple sclerosis


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: TAYLOR, JACQUELYN Y (contact)

PROJECT_TERMS: Academic Medical Centers;Address;anti-racism;Behavioral;Biological Factors;career development;Centers of Research Excellence;Collaborations;Communities;community academic partnership;community center;community engagement;Community Hospitals;community partners;community partnership;community-centered;design;Development;Discipline;Ensure;equity, diversity, and inclusion;ethnic disparity;experience;Financial Support;Fostering;Funding Opportunities;Goals;health equity;Health system;Hospitals;implicit bias;Inequity;innovation;Institution;Intervention;Justice;Knowledge;Leadership;Learning;learning community;Link;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Medical center;Mentors;Methodology;Methods;minority investigator;Modeling;Morbidity - disease rate;mortality;New York;New York City;next generation;novel;Outcome;Patients;people of color;Philosophy;Policies;Positioning Attribute;Pregnancy;Race;racial disparity;Research;Research Personnel;Research Training;Resources;Role;Schools;Science;Scientist;Self-reflection;Series;severe maternal morbidity;skills;social;Structural Racism;synergism;theories;tool;Training;training opportunity;Training Programs;Underrepresented Minority;United States;Universities;Work

PROJECT_TITLE: Career Development and Training Core


PI_NAMEs: VANWAGONER, TIMOTHY M (contact)

PROJECT_TERMS: Academia;Area;base;career;Centers of Research Excellence;Clinic;Clinical;clinical care;Collaborations;Communities;Competence;cultural health;design;Development;Discipline;education research;Ensure;Ethics;Faculty;Feedback;Fostering;Foundations;Funding;Goals;Health;health disparity;Health education;Health Professional;health training;Healthcare;Healthcare Systems;Hospitals;Human Resources;improved;Indigenous;indigenous community;Individual;Inequity;innovation;Institution;Intervention;Kansas;Maternal Health;Maternal health equity;Medical Students;Mentors;Mentorship;multidisciplinary;novel;Oklahoma;Outcome;Patients;Persons;Pilot Projects;Postdoctoral Fellow;Process;programs;Public Health;repository;Research;research in practice;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;resilience;Resource Development;Resources;Science;Scientist;Site;Solid;Source;student mentoring;Students;System;Texas;Training;Training and Education;training opportunity;Training Programs;Training Support;Translating;Translational Research;tribal health;Tribes;United States National Institutes of Health;web site

PROJECT_TITLE: Training and Development


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project narrative: Dysregulation of the tumor suppressors LATS1/2, core components of Hippo pathway, is common in many human tumors including breast cancer, but its upstream regulator and physiological role in breast tumorigenesis remains unclear. This proposal aims to elucidate how LATS1/2 kinase activity and tumor suppressive function is regulated by upstream deubiquitinase OTUD3, as well as to examine how LATS1/2 are critically involved in breast tumorigenesis through phosphorylating Raptor at Ser606, which in turn suppresses mTORC1 kinase activity.

PI_NAMEs: DAI, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Accounting;Automobile Driving;Award;Basic Science;Biochemical;Biological Assay;Biological Process;Breast;Breast Cancer Treatment;breast tumorigenesis;Cancer Biology;Cancer Diagnostics;cancer therapy;career;cell growth;Cell Physiology;Cell Polarity;Colorectal Cancer;Data;design;Deubiquitinating Enzyme;Deubiquitination;Development;Drosophila genus;druggable target;Ectopic Expression;Endometrial Carcinoma;experimental study;Family;Family member;Female Breast Carcinoma;fly;Future;Genetic Status;Genetically Engineered Mouse;Glioma;Goals;Growth;Human;In Vitro;in vivo;Individual;insight;Knock-in Mouse;LATS1 gene;Liver;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammals;mammary;Mammary Neoplasms;Mediating;Metabolism;Modification;Molecular;Molecular and Cellular Biology;Mouse Mammary Tumor Virus;Mus;Natural regeneration;Newly Diagnosed;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Organ Size;Orthologous Gene;Pathway interactions;Phase;Phosphorylation;Phosphotransferases;Physiological;polyoma middle tumor antigen;Polyubiquitination;Problem Solving;Process;Protein-Serine-Threonine Kinases;Proteins;Regulation;Role;Sarcoma;Scientist;Serine;Signal Pathway;Signal Transduction;Site;skills;targeted treatment;Time;Tissues;Training;Transcription Coactivator;Translational Research;tumor;Tumor Burden;Tumor Suppressor Proteins;tumorigenesis;ubiquitin isopeptidase;Ubiquitination;Woman

PROJECT_TITLE: Elucidating a Novel Mechanism for LATS1/2 in Suppressing Tumorigenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cerebrovascular;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PHYSICS

ORG_NAME: HUNTER COLLEGE

PHR: This project proposes to develop and validate ultrasonic-tagged remote interferometric flowmetry for brain activity with single-shot off-axis holography. The outcome of this project is a noninvasive imaging platform for quantifying the local dynamics inside deep tissue through ultrasonic tagging. It will pave the way for highly selective and accurate recording of local CBF and absorption variation associated with brain activity in human brains with millimeter spatial resolution and at a depth of one centimeter and be- yond.

PI_NAMEs: XU, MIN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: absorption;Address;biological systems;Blood;Blood flow;blood flow measurement;blood oxygen level dependent;Brain;Brain imaging;brain size;Caring;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;Cerebrum;Cognitive aging;cost;Detection;detection method;Diffusion;electric field;experimental study;Flowmetry;Focused Ultrasound;Functional Magnetic Resonance Imaging;Goals;hemodynamics;heterodyning;Holography;Human;Image;imaging platform;innovation;Laser Speckle Imaging;Lasers;Light;Lighting;Measurement;Measures;Metabolic;metabolic rate;Methods;millimeter;Monitor;Monte Carlo Method;Nature;neural;neuroimaging;Noise;non-invasive imaging;novel;Optical Methods;Optics;Outcome;Oxygen;Performance;Photons;portability;Process;quantum;real time monitoring;Research;Research Design;Resolution;Scheme;Signal Transduction;Site;Spectrum Analysis;Structure;Technology;Tissue imaging;Tissues;Ultrasonics;ultrasound;uptake;Variant;Work

PROJECT_TITLE: Ultrasonic-tagged remote interferometric flowmetry for brain activity


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Patient Safety;Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Adolescents living with HIV in sub-Saharan Africa are a particularly vulnerable group with poorer health outcomes than adults living with HIV. The proposed study will design, develop, and test in Kenya an interactive smartphone game for adolescents living with HIV focused on increasing their adherence to antiretroviral therapy and retention in HIV care and reducing their sexual risk, with a view to improving their health outcomes and preventing HIV transmission. This intervention has the potential to be highly scalable, low cost, and culturally adaptable to individual African countries; the study will also seek to advance the effective use of mobile devices in global health through structured capacity strengthening activities.

PI_NAMEs: WINSKELL, S KATE (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Active Learning;Address;Adherence;Adolescence;Adolescent;adolescent health outcomes;Adult;Africa;Africa South of the Sahara;African;Age;aged;antiretroviral therapy;Attitude;base;behavior influence;Behavior Therapy;Behavioral;care systems;Caregivers;Caring;Cellular Phone;Clinical;Communication;Continuity of Patient Care;coping;cost;cost effective;Country;Data;Data Collection;design;Development;digital;Disclosure;Education;efficacy trial;Electronics;Emotional;Environment;Epidemiology;Evidence based practice;experience;feasibility testing;Female;Funding;Future;global health;Goals;handheld mobile device;Health;HIV;HIV-infected adolescents;Human Resources;improved;Individual;Infection;Intervention;intervention effect;Kenya;Knowledge;Life;Life Expectancy;male;Managed Care;Mediating;Mediator;Medical Research;medication compliance;Mental Health;mHealth;Modeling;Morbidity - disease rate;mortality;Motivation;multidisciplinary;mutual learning;Outcome;pedagogy;Perinatal;Persons;Pharmaceutical Preparations;Pilot Projects;poor health outcome;Population;preadolescence;prevent;Randomized, Controlled Trials;Research;Research Institute;Resources;response;Risk;safety assessment;safety testing;Sampling;scaffold;Self Care;Self Efficacy;sexual and reproductive health;sexual risk taking;skills;social;Social Behavior;social cognitive theory;social stigma;Social support;Structure;Target Populations;Technology;Telephone;Testing;theories;Time;transmission process;treatment arm;unintended pregnancy;United States National Institutes of Health;Universities;uptake;usability;Vertical Disease Transmission;Viral;Viral Load result;virtual;Vulnerable Populations;Youth

PROJECT_TITLE: A Smartphone Game to Increase Engagement in Care among African Adolescents Living with HIV


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: LYELL, DEIRDRE  (contact)

PROJECT_TERMS: Accountability;Admission activity;Adopted;Adoption;adverse maternal outcomes;Affect;Anemia;antenatal;Awareness;Birth;Black race;California;Cesarean section;Childbirth;Childhood;Clinic;Clinical;clinical care;Communities;community partners;community-centered;data centers;Dedications;dietary;Discipline of obstetrics;Disparity;disparity reduction;Education;Ensure;Equity;Erythrocytes;ethnic disparity;Evaluation;evidence base;Evidence based practice;Exclusion;experience;Feedback;Frontline worker;Goals;Guidelines;health disparity;Health system;Hematology;Hemoglobin;Hemorrhage;Hispanic;Hospitals;Household;Impairment;implementation framework;implementation strategy;improved;Incidence;Income;Inequity;Infant;Infection;Inherited;innovation;Institution;Iron;iron deficiency;Iron deficiency anemia;iron supplementation;Latina;Latino;Latinx;Leadership;Link;Lived experience;Maternal Mortality;maternal risk;Measures;Methodology;Methods;Modeling;Modification;Native American population;novel;Oregon;Outcome;Oxygen;Pathway interactions;Patient Care;Patient Education;patient oriented;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Postpartum Hemorrhage;Pre-Eclampsia;Predisposition;Pregnancy;pregnant;Premature Birth;Prenatal care;prevent;Prevention;Prevention approach;Provider;Public Health;Qualitative Research;Quality of Care;Race;racial disparity;Reporting;Research;Resources;Risk;screening;severe maternal morbidity;Severities;Sickle Cell Anemia;Site;Source;Standardization;Structural Racism;Structure;System;Testing;Time;tool;trend;United States;usability;Uterus;Washington;webinar;Work

PROJECT_TITLE: Patient Centered Community and Clinical Approaches to Reduce Racial Disparities at Birth by Preventing Anemia


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Immunotherapy;Kidney Disease;Rare Diseases

PHR: PROJECT NARRATIVE Membranous nephropathy is a leading cause of nephrotic syndrome and end stage kidney disease. A better understand of disease pathophysiology is needed to develop more specific, hypothesis-driven therapies. This project will develop and apply new precise and high-throughput molecular techniques to characterize the T cell receptor repertoire of anti-PLA2R reactive T cells in patients with membranous nephropathy and characterize their transcriptional profile at a single-cell level.

PI_NAMEs: CRAVEDI, PAOLO  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: active method;Adult;Affect;Aftercare;Alloantigen;alpha-beta T-Cell Receptor;Antibodies;Antigen Targeting;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;Autologous;autoreactive T cell;B-Lymphocytes;Biological;Biological Markers;biomarker identification;Blood specimen;Blood Volume;CD4 Positive T Lymphocytes;Cell Compartmentation;Cells;Characteristics;Circulation;Clinical;Clinical Research;Cloning;Complement;cost effective;Couples;Data;Deposition;design;Development;Diagnosis;Disease;Disease remission;DNA Sequence;End stage renal failure;Epitope spreading;Epitopes;experience;Exposure to;Fc Receptor;Functional disorder;Gene Expression Profile;Gene Library;Generations;Genetic Transcription;glomerular basement membrane;high reward;high risk;Human;Human Herpesvirus 4;Immune response;Immune Tolerance;Immunologic Monitoring;In Vitro;Individual;Inflammatory;Injury;innovation;innovative technologies;kidney biopsy;Libraries;Link;Maps;Mediating;Membranous Glomerulonephritis;Molecular;Nephrotic Syndrome;novel strategies;Outcome;pathogen;Pathogenicity;Pathway interactions;patient screening;patient subsets;Patients;Peptide Receptor;Peptides;Peripheral Blood Mononuclear Cell;Phospholipase;Phospholipase A2;podocyte;prevent;Production;prophylactic;receptor;Receptor Cell;Recombinants;Renal glomerular disease;Research;Research Design;rituximab;Role;Sampling;screening;Severity of illness;Signal Transduction;single-cell RNA sequencing;Specificity;T cell regulation;T cell response;T-Cell Immunologic Specificity;T-Cell Receptor;T-Cell Receptor Genes;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;therapeutic target;Therapeutic Uses;tool;Tumor Antigens;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: High-throughput identification and transcriptional analysis of autoreactive T cells in individuals with membranous nephropathy.

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: MAIN, ELLIOTT K (contact)

PROJECT_TERMS: Address;Birth;Black Populations;black women;California;Caring;Cesarean section;Clinical;clinical practice;Collection;Communities;Community Health;Community of Practice;Complex;cultural equity;Data;data centers;Data Set;Discipline of obstetrics;Disparity;disparity elimination;disparity reduction;effectiveness analysis;effectiveness evaluation;Equity;Ethnic Origin;Evaluation;experience;Hemorrhage;high risk;Hospitals;implementation strategy;improved;Individual;Inequity;insight;Institution;Intervention;Interview;Language;Life;Link;Lived experience;Maternal Health;maternal outcome;Measures;Methods;microaggression;Morbidity - disease rate;mortality;novel;obstetric care;Outcome;Outpatients;patient oriented;Patients;payment;people of color;Performance;Persons;Population;Postpartum Hemorrhage;postpartum morbidity;Postpartum Period;prevent;Process;prospective;Provider;Public Health;Qualitative Methods;Quality of Care;Race;racism;Reporting;Research;Resources;response;Risk;severe maternal morbidity;Structure;Surveys;System;Time;tool;Translating;United States;Vaginal delivery procedure;Validation;Voice;web site;Woman;Work

PROJECT_TITLE: Equity in Obstetrics: Reducing disparities in rates of cesarean birth and cesarean-linked hemorrhages


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Rehabilitation;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE By understanding how cancer treatments alter the course of biological and functional aging in cancer survivors, our study can help to guide patient care. Specifically, our study will help identify patients at risk for long-term physical function impairment as a result of cancer treatment, provide clues as to the biological mechanisms through which these adverse effects occur, and inform future strategies to mitigate these effects.

PI_NAMEs: BINDER, ALEXANDRA MARGARET LYNN;FELICIANO, ELIZABETH MARJORIE CESPEDES (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;Adjuvant Therapy;Adult;Adverse effects;Affect;Aftercare;Age;age acceleration;age related;Aging;aging biomarker;aging related;Anthracycline;anti-cancer research;Biological;Biological Aging;Biological Assay;Biology of Aging;biomarker validation;Blood specimen;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer survivor;cancer diagnosis;Cancer Survivor;cancer therapy;Caring;Characteristics;chemoradiation;Childhood Cancer Survivor Study;Chronology;Clinical;clinical diagnosis;cohort;comparison control;Data;design;Diagnosis;DNA Methylation;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;Ethnic Origin;experience;Follow-Up Studies;frailty;functional decline;functional status;Future;Goals;hazard;Health;healthspan;human old age (65+);Impairment;indexing;Intervention;life span;Life Style;Long-Term Survivors;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Modality;Molecular;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;Nutritional;Operative Surgical Procedures;optimal treatments;Patient Care;Patient Self-Report;Patients;Pattern;performance tests;personalized intervention;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Physiological;Population;Postmenopause;Pre-Clinical Model;premature;Race;Radiation;rate of aging;Recording of previous events;Rejuvenation;Research;Risk;Severities;Survival Rate;Survivors;survivorship;Testing;Time;Toxic effect;treatment duration;United States;Variant;Woman;Women's Health;Work

PROJECT_TITLE: Long-Term Trajectories of Accelerated Biological Aging and Functional Decline Associated with Breast Cancer and its Treatment

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: ROSAS, LISA GOLDMAN (contact)

PROJECT_TERMS: Affect;Anemia;Asian;Biomedical Research;Black race;Clinical;Communication;Communities;community academic partnership;community engaged research;community engagement;community organizations;community partners;community partnership;Country;Data;Dedications;design;digital;disparity reduction;Equity;experience;Goals;Grant;Health;health equity promotion;Health Services Accessibility;Healthcare;Hemorrhage;improved;Income;Inequity;innovation;Intervention;Latinx;Leadership;Learning;Lived experience;Maternal Health;Maternal health equity;Maternal Mortality;Mental Health;Mothers;Native American population;obstetrical complication;Outcome;Outcome Study;patient engagement;Patient-Focused Outcomes;Patients;Persons;Phase;physical conditioning;Policies;Population;Postpartum Hemorrhage;Postpartum Period;pregnant;prevent;programs;Provider;Research;Research Priority;Research Project Grants;Research Training;Resources;Risk;severe maternal morbidity;Training;Translating;Translational Research;Translations;uptake;Work

PROJECT_TITLE: COMMUNITY ENGAGEMENT AND PARTNERSHIP (CEP)