NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Physical Activity;Prevention;Women's Health Research

PHR: OPACH2 is a prospective study of 6489 women (50% of whom are black or Hispanic) initially aged 63-99 years who wore a small device on their hip for 7 days in 2012-2014 to measure movement and sitting during their usual activities. The study is designed to investigate and compare different measures of physical activity intensity across the full range of effort from sitting still to light to moderate to vigorous activity taking into account a woman’s maximum effort possible. We propose to compare how strongly different physical activity intensity measures predict the occurrence of new cardiovascular disease events (heart attacks, heart failure, stroke) and mortality, as well as several indicators underlying cardiovascular health including traditional risk factors like blood cholesterol levels, newer blood measures of heart injury (cardiac troponin, natriuretic peptide, galactin-3), changes in heart rate regulation (heart rate variability) and tests of physical functioning.

PI_NAMEs: LACROIX, ANDREA Z. (contact);LAMONTE, MICHAEL J

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Accelerometer;Adult;Aerobic;Aerobic Exercise;Age;age related;age related changes;aged;Aging;American;Ancillary Study;Basal metabolic rate;Blood;Blood Pressure;Brain natriuretic peptide;Calibration;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cholesterol;Classification;Clinical;comorbidity;Coronary heart disease;cost;Data;design;Devices;Diagnosis;disability burden;Dose;Event;evidence base;exercise capacity;follow-up;Goals;Guidelines;Habits;Health;heart disease risk;Heart failure;Heart Injuries;Heart Rate;heart rate monitor;heart rate variability;Heterogeneity;high risk;Hip region structure;Hispanic;Hour;human very old age (85+);Incidence;Individual;Inflammation;Laboratories;Life;Light;Lipids;Measurement;Measures;men;Mobility disability;Monitor;mortality;mortality risk;Movement;Myocardial Infarction;National Heart, Lung, and Blood Institute;Natriuretic Peptides;novel marker;Obesity;older adult;older men;older women;Pathology;Patient Self-Report;Pattern;peer;Physical activity;Physical Function;Physical Performance;Physiological;Pilot Projects;Premature Mortality;Prevalence;Prospective Studies;Prospective, cohort study;Publishing;Questionnaires;Recurrence;Regulation;Reporting;Research Personnel;response;Risk Factors;sedentary;sedentary lifestyle;Silver;Stroke;success;Surface;Testing;Troponin;Tsunami;VO2max;Vulnerable Populations;Walking;Woman;Women's Health

PROJECT_TITLE: Objective Physical Activity and Cardiovascular Health in Older Women: OPACH2

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE ADP-ribosylation is a post-translational modification that targets hundreds of mammalian proteins and mediates a broad spectrum of biological activities, including DNA repair, transcription, translation, and protein stability. This research program will develop new technologies to study the regulation and function of specific protein ADP-ribosylation events, and investigate mechanisms that enable mono- and poly-ADP-ribosylation to operate in numerous non-overlapping cellular signaling pathways. A more clear understanding of how cells control and employ ADP-ribosylation is becoming increasingly important as PARP inhibitor development efforts and clinical applications continue to expand for the treatment of cancer and other human diseases.

PI_NAMEs: LISZCZAK, GLEN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP ribosylation;Amino Acids;beta catenin;Biochemical;Biological;Biology;cancer therapy;Cardiovascular system;Cells;Chemicals;Cherubism;chromatin remodeling;Clinical;clinical application;Complex;Development;developmental disease;Disease;DNA Damage;DNA Repair;DNA Repair Disorder;Environment;Enzymes;Event;Functional disorder;Genetic Transcription;human disease;inhibitor;Knowledge;Length;Malignant Neoplasms;Mediating;Modification;Molecular;Nature;new technology;novel strategies;Nucleosomes;Output;Peptides;Physiology;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymers;Positioning Attribute;Post-Translational Protein Processing;Process;programs;protein function;Protein Isoforms;Proteins;reconstitution;Regulation;Reporting;Research;Serine;Side;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;Site-Directed Mutagenesis;Technology;TNKS gene;Translations;Work

PROJECT_TITLE: Regulation and function of site-specific protein poly-ADP-ribosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a new and alternative strategy to treat cancer that simultaneously inhibits a common mutated oncoprotein (BRAF) and induces a mechanism of cell death (ferroptosis) that are involved in the growth and spread of variety of human cancers. Once such a strategy has been developed, there is a potential for a significant advance in anti-cancer therapy for advanced cancers that fail standard treatment approaches. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: KEBEBEW, ELECTRON  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: acquired treatment resistance;Advanced Malignant Neoplasm;anaplastic thyroid cancer;anticancer activity;Apoptosis;BRAF gene;cancer cell;Cancer cell line;cancer therapy;Cell Death;cell type;Cells;Cessation of life;Clinic;combinatorial;Combined Modality Therapy;Data;Death Rate;Development;Diagnosis;disability;efficacy evaluation;evidence base;Future;Gatekeeping;Goals;Growth;Human;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Iron;Knowledge;Lipids;Malignant neoplasm of thyroid;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Melanoma;Mesenchymal;Mission;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;mutant;Mutate;Mutation;novel;novel therapeutic intervention;Oncoproteins;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Peroxidases;Persons;pre-clinical;preclinical safety;Public Health;Refractory;Research;Resistance;response;Safety;Science;Signal Induction;Signal Pathway;standard care;Testing;Therapeutic;therapeutic effectiveness;Time;Toxic effect;translational framework;Translations;Treatment Efficacy;Treatment Protocols;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: Targeting Ferroptosis in BRAF (V600E) Mutant Anaplastic Thyroid Cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Wound Healing and Care

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project directly addresses the escalating national rate of major (above-ankle) amputations due to diabetic foot ulcers; it focuses on rural patients, who face 37% higher odds of major amputation compared to their urban counterparts. The project pilots the first integrated care model adapted to rural settings, an approach that has reduced major amputations in urban settings by approximately 40%. Pilot data will be used to improve recruitment and retention strategies and provide preliminary evidence of efficacy needed to conduct a robust, statewide efficacy trial.

PI_NAMEs: BRENNAN, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Agreement;Algorithms;American;Amputation;Ankle;Automobile Driving;Award;Blood Vessels;Caring;Cessation of life;Clinic;Clinical;Clinical Trials;clinically significant;cohort;Collaborations;Communicable Diseases;Complications of Diabetes Mellitus;Consultations;Consumption;cost;Data;Dedications;design;Diabetes Mellitus;Diabetic Foot Ulcer;Diagnostic;Disease;efficacy trial;Electronic Health Record;Engineering;Face;feasibility trial;Feedback;follow-up;Foot Ulcer;glycemic control;Goals;Guidelines;Health;health disparity;Health Personnel;Health system;Healthcare Systems;high risk;improved;Infection;innovation;integrated care;Intervention;Ischemia;limb loss;Measures;Mechanics;medical specialties;Minor;Modeling;multi-site trial;National Institute of Diabetes and Digestive and Kidney Diseases;Operative Surgical Procedures;Outcome;Participant;Patients;Phase;Physiological;Pilot Projects;Population;Preparation;Primary Care;primary care setting;Process;programs;Provider;recruit;Reporting;Research;Research Personnel;retention rate;Risk;Risk Reduction;Rural;rural disparities;Rural Health;rural health clinic;rural health disparities;rural healthcare;rural patients;Rural Population;rural setting;secondary infection;Side;Specialist;success;systematic review;Telefacsimile;tertiary care;Testing;Time;tool;Triage;United States Health Resources and Services Administration;Universities;Urban Health;urban setting;Vascular Diseases;Wisconsin;Work;wound care

PROJECT_TITLE: Crossing the divide: piloting an integrated care model to bridge rural-urban healthcare systems and reduce major amputations among rural patients with diabetic foot ulcers

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Genetics;Nutrition;Prevention;Women's Health Research

PHR: Narrative As the population ages, the number of people suffering from age-related diseases including cancer is also increasing. Our knowledge of how cancer develops naturally during aging, and how host age impacts cancer development and progression, has been limited by the use of young, inbred animal models for cancer studies. Here, we will utilize methionine restriction (MR) as a geroprotective treatment paradigm, determining the effect of MR on cancer frequency, type, and the epigenome in wild-type genetically heterogeneous animals, testing how host and tumor age interact with MR in multiple xenograft breast cancer models to determine cancer phenotypes and epigenetic response, and determine the role of a specific molecular mediator of the benefits of MR in cell culture and in vivo.

PI_NAMEs: CRYNS, VINCENT L.;DENU, JOHN M;LAMMING, DUDLEY WILLIAM (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 4T1;Address;Adult;Affect;Age;age effect;age related;Age related pathologies;age-related disease;aged;Aging;aging process;aging related;Amino Acids;Anabolism;Animal Cancer Model;Animals;anti-cancer;anti-cancer research;antitumor effect;Biological;Breast Cancer Cell;Breast Cancer Model;Breast Carcinoma;cancer initiation;cancer therapy;Cell Culture Techniques;Cell model;Cells;Dependence;Development;Diet;dietary;Dietary Component;Dietary Intervention;Dietary Proteins;dietary restriction;DNA Methylation;DNA Modification Methylases;DNA Modification Process;Ensure;Epigenetic Process;epigenetic profiling;epigenome;experimental study;extend lifespan;Frequencies;Gene Expression Profiling;genetic approach;Genetic Transcription;geroprotection;geroprotector;Health;Health Benefit;healthspan;healthy aging;High Prevalence;histone methylation;histone methyltransferase;histone modification;Human;Immunodeficient Mouse;improved;in vivo;Inbred Strain;Inbreeding;Individual;insight;Integration Host Factors;interest;Intervention;juvenile animal;Knowledge;life span;Link;Longevity;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;Mediator;Metabolic;metabolic phenotype;Metabolism;Methionine;Methionine Metabolism Pathway;model organism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;multidisciplinary;Mus;mutant;Neoplasm Metastasis;Normal tissue morphology;novel;old mice;older women;Pathway interactions;patient derived xenograft model;Persons;pharmacologic;Phenotype;Plants;Play;Population;prevent;Prevention;pro-aging;Property;Protein Kinase;Rattus;Regulation;Research;Resistance;response;Rodent;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;self-renewal;sensor;Site-Directed Mutagenesis;Societies;stem;Techniques;Testing;tumor;tumor growth;tumor initiation;tumor progression;Tumor Tissue;tumorigenesis;Vegan Diet;Work;Xenograft procedure

PROJECT_TITLE: The regulation of cancer and aging by methionine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE Cocaine use disorder is a serious problem in today’s society, and there are no effective therapeutics available. Stress is known to increase cocaine relapse vulnerability, and we posit that a major component of the endogenous stress system, the kappa opioid receptor, underlies stress-cocaine interactions. This proposal explores the potential of blocking kappa opioid receptor-induced phosphorylation of one protein, the dopamine transporter, which is the primary target of cocaine, in reducing the rewarding effects of cocaine and drug- seeking behavior.

PI_NAMEs: JAYANTHI, LANKUPALLE D;JONES, SARA RAULERSON;RAMAMOORTHY, SAMMANDA  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Affect;Affinity;Anesthesia procedures;Animals;Attenuated;Behavior;Behavioral;behavioral study;Biochemical;Brain;Brain region;Chronic;Cocaine;Cocaine Dependence;cocaine exposure;cocaine relapse;cocaine related behaviors;cocaine reward;Cocaine use disorder;Complex;conditioned place preference;Corpus striatum structure;Disease;Dopamine;dopamine transporter;dopaminergic neuron;Dose;drug seeking behavior;Dynorphins;Etiology;extracellular;Fiber;Goals;Healthcare;in vivo;Individual;insight;Intake;Interruption;Investigation;kappa opioid receptors;Knock-in Mouse;Knowledge;Ligands;Link;Measurement;Measures;Mediating;Microdialysis;Modeling;Modification;Molecular;mouse model;Mus;mutant;negative affect;Neurobiology;neurochemistry;Neurons;neurotransmission;novel;Nucleus Accumbens;Opioid agonist;Opioid Antagonist;optogenetics;Outcome;Pathogenesis;Periodicity;Persons;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Photometry;Play;Post-Translational Protein Processing;Pre-Clinical Model;presynaptic;protein protein interaction;Proteins;Quality of life;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recombinant adeno-associated virus (rAAV);regional difference;Regulation;Relapse;Reporting;Resources;response;Retroviral Vector;Rewards;Role;Scanning;sensor;sex;Signal Transduction;Site;Slice;Societies;Stress;Substance Use Disorder;Surface;Swimming;Synaptosomes;syntaxin 1A;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Threonine;Time;trafficking;transmission process;Up-Regulation;uptake;Viral;Wild Type Mouse

PROJECT_TITLE: Kappa Opioid Receptors and Phospho-Dopamine Transporters Drive Cocaine Reward

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This multidisciplinary five-year program is designed to train postdoctoral research fellows working at the intersection of nanoscience and cancer research. The goal is to prepare scientists who will successfully pursue careers in academia, industry, and government agencies, and will become significant contributors to addressing emerging challenges in public health and medical research using nanotechnology to diagnose and treat cancer.

PI_NAMEs: KABANOV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: CAROLINA CANCER NANOTECHNOLOGY TRAINING PROGRAM (C-CNTP)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE At this exceptional time in oncology, fundamental discoveries in our understanding of cancer biology are leading to dramatic changes in cancer therapies, ranging from genotype-directed targeted therapies, to antibody and cell-based immunotherapies, and the application of liquid biopsies to enable the earlier detection of cancer. There is a critical need for physician scientists who are expert in both sophisticated molecular approaches to science and the clinical challenges of caring for patients with cancer, and who can lead innovation in basic, translational and clinical cancer research, and bridge between rapidly evolving fields. The MGH T32 physician scientist Training Program in Cancer Biology and Therapeutics selects trainees from the most competitive clinical programs at our institution, offering them advanced training in either laboratory or clinical cancer research, with highly accomplished mentors drawn from a multidisciplinary faculty at MGH, as well as our partnering institutions at Harvard and MIT. Over the past 25 years, graduates of the MGH T32 grant have made and will continue to make major contributions to the field of cancer research, and as members of the faculty at our own institution and others in the US, they are poised to emerge as the next generation of physician leaders in oncology, contributing to the critical integration of scientific and clinical innovation in cancer.

PI_NAMEs: HABER, DANIEL A. (contact);SEQUIST, LECIA V.


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Substance use in pregnant women has increased over the past decade, highlighting the importance of efforts to understand how environmental and other exposures during pregnancy affect brain development and child outcomes. The PRELUDE consortium for the HEALthy Brain and Child Development study will recruit 2720 pregnant women in the 2nd and 3rd trimester and follow their children to age 10, using neuroimaging, behavioral assessments, EEG, biosample collection, and assessments of parent-child interaction and the home environment. This research will lead to greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.

PI_NAMEs: MERHAR, STEPHANIE L (contact);VANNEST, JENNIFER J.

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Age;Alcohol consumption;Arkansas;Behavior assessment;Behavioral;Biological;Biological Factors;Birth;Brain;Child;Child Development;Childhood;clinical care;Clinical Research;Cognitive;cohort;Collaborations;Collection;Communities;community engagement;Data;Data Analyses;Data Coordinating Center;data exchange;Dedications;design;Development;early childhood;Electroencephalography;Emotional;Enrollment;Ensure;Environmental Risk Factor;Ethics;Ethnic Origin;evidence base;Exposure to;Family;fetal;Funding;General Population;Genetic;Geography;Goals;Helping to End Addiction Long-term;high risk;high risk infant;high risk population;Home environment;Image;improved;improved outcome;Infant;insight;Institution;Intervention;Legal;Longitudinal Studies;Magnetic Resonance Imaging;Maternal and Child Health;Maternal Health;maternal outcome;maternal stress;Measures;Medical center;Mental Health;Mothers;neurodevelopment;neuroimaging;neurophysiology;North Carolina;nutrition;Opiate Addiction;Opioid;opioid misuse;Outcome;Parent-Child Relations;Parents;Participant;Pediatric Hospitals;Phase;Physiological;post pregnancy;Poverty;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal experience;prenatal exposure;Protocols documentation;Public Health;Questionnaires;Race;recruit;Research;Research Institute;resilience;Resources;Risk;Risk Factors;risk minimization;Sample Size;Sampling;School-Age Population;Second Pregnancy Trimester;Series;Site;social;socioeconomic diversity;Speed;stem;substance use;Third Pregnancy Trimester;Tobacco;Toxic Environmental Substances;United States National Institutes of Health;Universities;Visit;wearable device;Work

PROJECT_TITLE: 4/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on a novel therapeutic strategy for castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NCI's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LI, ZHIGUO  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: advanced prostate cancer;Alleles;androgen deprivation therapy;androgen independent prostate cancer;Androgens;anti-PD-L1 therapy;Apoptosis;Autophagocytosis;Biometry;Breeding;cancer cell;Cancer Etiology;Cancer Patient;cell growth;Cell Survival;Cells;Cellular biology;Cessation of life;Clinic;Clinical Research;comparative efficacy;Creativeness;Data;design;Disease;effective therapy;Enterobacteria phage P1 Cre recombinase;Fostering;Genetically Engineered Mouse;Goals;Health;immune cell infiltrate;Immune checkpoint inhibitor;Immunocompetent;Immunosuppression;Immunotherapy;improved;Infiltration;inhibitor;innovation;Investigation;Lymphocyte;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Mediating;Membrane;men;Mission;Molecular;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;novel;novel strategies;novel therapeutic intervention;nuclear factor-erythroid 2;Oncology;Outcome;Oxidative Stress;Pathology;Patient-Focused Outcomes;Patients;PDL1 inhibitors;PDL1 pathway;pharmacologic;Phosphorylation;Phosphotransferases;Play;PLK1 gene;Prognosis;programmed cell death ligand 1;programs;Proliferating;promoter;prostate cancer cell;Prostate Cancer therapy;Public Health;Reactive Oxygen Species;receptor;Refractory;Regulation;Research;Residual state;response;Role;Signal Pathway;Signal Transduction;Survival Rate;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutically effective;Treatment Efficacy;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor xenograft;tumor-immune system interactions;Tumor-infiltrating immune cells;Up-Regulation;Work

PROJECT_TITLE: Targeting Polo-Like Kinase 1 in Prostate Cancer to Enhance Therapeutic Efficacy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: COLLIGA APPS CORP.

PHR: PROJECT NARRATIVE Mental health problems in childhood are highly prevalent and impairing, placing an immense social and economic burden on society. Parent-child relationships in the early years of life play a critical role in promoting child mental health, with critical and coercive relationships increasing the risk of mental health problems across the lifespan. Our project includes the creation and systematic evaluation of an innovative technology-based therapy system that employs artificial intelligence to monitor and responsively administer dynamic (i.e., as needed) supports to families in real-world settings in order to promote positive family relationships and improve child mental health.

PI_NAMEs: AHLE, MATTHEW WILLIAM (contact);COMER, JONATHAN S;TIMMONS, ADELA

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: adaptive intervention;Address;Adult;Age;Aggressive behavior;Algorithms;analytical method;Anxiety;Appointment;Area;Artificial Intelligence;barrier to care;Behavior;Behavioral;Businesses;Caregivers;Cellular Phone;Cessation of life;Child;Child Mental Health;Child Rearing;Childhood;comparison control;Computer software;Conflict (Psychology);contagion;cost effective;Couples;Data;Data Analytics;data sharing;design;Development;digital solutions;Distal;early childhood;Early Intervention;Economic Burden;Ecosystem;Educational Curriculum;Effectiveness;efficacy evaluation;efficacy testing;Emotions;Engineering;Evaluation;Event;Exposure to;Family;Family Relationship;family support;flexibility;foster child;Fostering;Goals;handheld mobile device;health care availability;Health Services Accessibility;Heart Diseases;Home visitation;Hour;Impairment;improved;in vivo monitoring;Individual;innovation;innovative technologies;interdisciplinary collaboration;Internet;Intervention;invention;Learning;Life;life span;Link;Machine Learning;machine learning algorithm;machine learning method;machine learning prediction algorithm;Malignant Neoplasms;Measurement;Measures;Mediating;Mental Depression;Mental Health;Mental Health Services;Methods;mobile computing;mobile sensing;Modality;Modeling;Monitor;Moods;National Institute of Mental Health;new technology;Outcome;Parent-Child Relations;parenting intervention;Pattern;Performance;Persons;Phase;physical conditioning;Play;Population;Populations at Risk;prevent;preventive intervention;Process;programs;protective effect;psychologic;Psychologist;Psychology;Public Health;randomized, clinical trials;Reporting;Research;research and development;Resources;response;Risk;Role;Safety;Sampling;Schools;Scientific Advances and Accomplishments;service delivery;Service delivery model;social;Societies;Stress;substance use;symptomatic improvement;Symptoms;System;Technology;technology development;technology intervention;technology platform;Testing;Therapeutic;therapeutic effectiveness;Time;Training and Education;treatment response;Underserved Population;wearable device;Work

PROJECT_TITLE: The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health


NIH_SPENDING_CATS: Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative We have discovered Kidney Injury Molecule-1 (KIM-1), a protein that kidney proximal tubule cells express when they are injured. If KIM-1 is expressed over longer periods of time it leads to progressive kidney failure. KIM-1 acts to increase re-uptake of many noxious molecules that the kidney filters including albumin with bound fatty acids. Our goal is to understand how this uptake leads to organ failure so that we can develop strategies to prevent progression of chronic kidney disease, reducing side effects such as cardiovascular disease and the need for hemodialysis or transplantation.

PI_NAMEs: BONVENTRE, JOSEPH VINCENT (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Albumins;Algorithms;Anemia;Animal Model;Animals;Antigen Presentation;Architecture;Autophagocytosis;Binding;Binding Sites;Biological Markers;Blood;Canis familiaris;Cardiovascular Diseases;Cell Aging;Cell Cycle Arrest;cell dedifferentiation;cell injury;Cell Line;Cell Separation;Cells;Characteristics;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;Complex;Cryoelectron Microscopy;Cytoskeleton;Development;Diabetic mouse;Diabetic Nephropathy;DNA Damage;Drug Targeting;Endocytosis;energy balance;Epithelial Cells;epithelial repair;extracellular;Family suidae;fatty acid oxidation;fatty acid-binding proteins;Fatty Acids;Fibronectins;Fibrosis;FRAP1 gene;Functional disorder;G2/M Arrest;Generations;Genetic Models;glomerular filtration;Goals;Grant;Heart Hypertrophy;Hemodialysis;Human;human pluripotent stem cell;Hypertension;Impairment;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;inhibitor;injured;Injury;Injury to Kidney;Integrins;interstitial;Ischemia;Kidney;kidney epithelial cell;Kidney Failure;Link;Lymphoid Tissue;man;MAP Kinase Gene;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monoclonal Antibodies;mouse genetics;mouse model;Mucins;Mus;mutant;Myofibroblast;nephrotoxicity;NF-kappa B;non-diabetic;Nonesterified Fatty Acids;novel;Nuclear;Organ failure;Organoids;Oxidants;oxidized lipid;oxidized low density lipoprotein;Palmitates;Palmitic Acids;Pathway interactions;Phagocytes;Phagocytosis;Phagosomes;Phenotype;phosphatidylserine receptor;PIK3CG gene;Plasma;Play;polyclonal antibody;Population;pre-clinical;prevent;Process;Production;Proteins;Proximal Kidney Tubules;Qualifying;rat KIM-1 protein;Rattus;Regulation;Regulatory T-Lymphocyte;Renal Cell Carcinoma;repaired;Reporting;response;reuptake;Rodent;Role;safety study;screening;Secondary Hypertension;senescence;senescence associated secretory phenotype;side effect;Signal Transduction;small molecule libraries;Structure;System;therapeutic target;Time;Tissues;Toxic effect;Transplantation;Tubular formation;Up-Regulation;uptake;urinary;Urine;Zebrafish

PROJECT_TITLE: Kidney Injury Molecule-1 in Epithelial Repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Adolescence is a period in which the brain networks that support goal-directed decision-making undergo pronounced reorganization. It is also the typical age of clinical onset for most forms of mental illness. This project will leverage recent advances in computational modeling, which enable the quantification of parameters that govern learning and decision-making, in order to characterize the neurocognitive decision-making phenotype of adolescents and to relate this phenotype to psychopathology.

PI_NAMEs: NIV, YAEL  (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Development;Adult;Age;age related changes;Anxiety;Attention deficit hyperactivity disorder;Back;Behavior;Behavioral;Brain;Characteristics;Child;Childhood;Clinical;clinical diagnosis;clinical diagnostics;clinical predictors;Cognitive;cognitive process;comorbidity;computer framework;Computer Models;cost;Data;Decision Making;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Early Diagnosis;Early Intervention;Early treatment;follow-up;Functional Magnetic Resonance Imaging;generalized anxiety;Goals;improved;indexing;Individual;Israel;Joints;Learning;Link;Maps;Measures;Mental Depression;Mental disorders;Modeling;Motivation;multimodal modeling;multimodality;multitask;neural;neural circuit;neural network;Neurocognitive;neuroimaging;neuromechanism;novel;Outcome;Pathology;Patient Self-Report;peer;Phenotype;Population;Prefrontal Cortex;Prevalence;prevent;Process;Prognosis;Property;Psychological reinforcement;Psychopathology;Research;Research Activity;Research Proposals;response;Running;Sampling;Scanning;Structure;support network;symptomatology;Symptoms;Testing;web based interface

PROJECT_TITLE: CRCNS US-Israel Research Proposal: Computational Phenotyping of Decision Making in Adolescent Psychopathology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Delineating an anterior cingulate-claustrum-parietal cortical circuit underlying cognitive control and attention No treatments targeting the alleviation of cognitive dysfunction exist for psychiatric patients, and numerous clinical trials have failed likely due to the use of targets not validated from circuits specific to affected cognitive domains. To address this challenge, the circuits underlying cognitive control and attention in patients need to be delineated with evidence that they are pharmacologically manipulable. By combining contemporary neuroscience techniques with the 5-choice continuous performance test that is consistent with challenges used in humans, we will determine the neural circuitry underlying cognitive control and attention to delineate the mechanistic underpinnings and pharmacological effects on these circuits that drive behavior.

PI_NAMEs: YOUNG, JARED WILLIAM (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;Agonist;Animals;Anterior;Attention;attentional control;Behavior;Behavioral;Brain region;Cholinergic Antagonists;cingulate cortex;Claustral structure;Clinical Trials;Cognition;Cognitive;cognitive control;cognitive neuroscience;cost;Data;dopamine transporter;DRD4 gene;Drug Controls;Drug Modulation;efficacious treatment;Failure;Family;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Human;Ibotenic Acid;Impaired cognition;Impairment;improved;inhibitor;Institution;Lesion;Link;Marketing;Masks;Measures;Mediating;Mental disorders;Modafinil;Modernization;Mus;Muscarinics;National Institute of Mental Health;neural;neural circuit;Neurons;neurophysiology;Neurosciences;noradrenaline transporter;novel;off-label use;optogenetics;Outcome;Parietal;Parietal Lobe;Participant;Patients;Performance;performance tests;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photometry;pre-clinical;preclinical study;Process;Psychiatry;Quinolinic Acid;Rattus;receptor;Reporting;Research Domain Criteria;response;Rodent;Role;Scopolamine;sex;societal costs;Stimulus;success;suicide rate;Task Performances;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;touchscreen;Validation;Work

PROJECT_TITLE: Optimization of the 5-choice continuous performance test to reveal a parietal-anterior cingulate-claustrum circuit underlying cognitive control and attention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-B(90)M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: PROJECT NARRATIVE This project will develop and characterize autofluorescence lifetime microscopy for label-free imaging and quantification of cellular metabolism and mitochondria function in living cells with high temporal and spatial resolution. Advancements in quantitative metabolic assays will reveal new insights into the fundamental effects of anesthetics on mitochondria and cell metabolism, reduce the side-effects and toxicities of anesthetics, ensure optimal care for patients with metabolic disease including neurodegenerative disorders, and characterize potential confounding effects due to anesthesia in pre-clinical and clinical studies of metabolism and metabolic defects.

PI_NAMEs: WALSH, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Abnormal Cell;Adoption;Anesthesia procedures;Anesthetics;Antibodies;Award;Biological Assay;Carbon;Cells;Cellular biology;Cellular Metabolic Process;Chemicals;Clinical Research;Cytosol;Defect;design;Detection;Development;Disease;Ensure;experimental study;Flavin-Adenine Dinucleotide;Fluorescence;fluorodeoxyglucose positron emission tomography;Genomics;Goals;Image;Impairment;in vivo;insight;Label;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Metabolism;metabolomics;Microscopy;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;Nature;Neurodegenerative Disorders;Nicotinamide adenine dinucleotide;Outcome;Oxygen Consumption;Pathologic;Pathway interactions;Patient Care;Pharmaceutical Preparations;pharmacologic;preclinical study;prevent;programs;Protocols documentation;Reporting;Research;Research Personnel;Resolution;Sampling;Sensitivity and Specificity;side effect;Signal Transduction;Specificity;Techniques;temporal measurement;Testing;Tissues;tool;Toxic effect;whole body imaging

PROJECT_TITLE: Autofluorescence lifetime microscopy for label-free detection of cell metabolism for cell biology research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in the mammalian brain and for studies of neurodevelopmental diseases. During development, the astonishing diversity of cell types present in the adult brain is thought to be established through sequential changes in gene expression during cellular maturation and differentiation, and further refinement with emerging brain connectivity and function. To gain a deeper understanding of this highly complex process, we aim to combine multiple single- cell genomics technologies to generate a comprehensive cell atlas of the developing mouse brain, intended to serve as a first-of-its-kind foundational resource to the neuroscience community for the study of mechanisms of mammalian brain development and neurodevelopmental disorders.

PI_NAMEs: ARLOTTA, PAOLA  (contact);NOWAKOWSKI, TOMASZ ;ZENG, HONGKUI

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 3-Dimensional;Adult;Age;Anatomy;ATAC-seq;Atlases;Bar Codes;base;Brain;brain cell;brain circuitry;candidate identification;Cell Differentiation process;Cell Lineage;Cell Maturation;cell motility;Cell Physiology;cell type;Cells;Censuses;Classification;Communities;comparative;Comparative Study;Complex;Computational algorithm;Computing Methodologies;CRISPR screen;Data;data integration;data resource;Data Set;Development;Embryo;epigenomic profiling;epigenomics;Event;Evolution;experience;Experimental Models;Funding;Gene Expression;Genetic Transcription;genomic data;Genomics;Goals;Human;Human Development;human disease;In Situ;in utero;in vivo;innovation;insight;Investigation;Knowledge;Laboratories;large scale data;Length;life span;Link;Maps;Methods;Modality;Molecular;mouse model;multiple omics;Mus;Nature;nerve stem cell;Neurodevelopmental Disorder;Neurosciences;nonhuman primate;Pattern;postnatal;postnatal development;prenatal;Process;prospective;Protein Isoforms;Regulation;Research Personnel;Resolution;Resources;response;Sampling;scale up;Science;Second Pregnancy Trimester;sensory input;single cell genomics;single nucleus RNA-sequencing;single-cell RNA sequencing;Somatosensory Cortex;Spatial Distribution;spatial relationship;Taxonomy;Technology;temporal measurement;Testing;Time;timeline;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;Validation;Viral Vector

PROJECT_TITLE: Comprehensive single-cell atlas of the developing mouse brain


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Communication between the endoplasmic reticulum (ER) and mitochondria is essential to maintain glucose homeostasis and whole-body energy balance. However, our knowledge on the regulatory elements that control the crosstalk between these two organelles, especially the regulation of mammalian mitochondrial protein import machineries and cellular respiration by the ER in health and disease, is very limited. Therefore, the goal of this proposal is to define mitochondrial-ER signaling pathways that control cellular function and energy expenditure in brown adipocytes during diet and thermal stress.

PI_NAMEs: LATORRE MURO, PEDRO ANTONIO (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: acid stress;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Affect;age related;age-related disease;Amino Acids;Award;Binding;Biochemical;Bioenergetics;Biogenesis;Blood Glucose;blood glucose regulation;Body Weight;bone;Cardiovascular Diseases;career development;Cell Physiology;Cell Respiration;Cellular biology;Client;Collaborations;Communication;Communities;Complex;Country;CRISPR/Cas technology;Crista ampullaris;Cryoelectron Microscopy;Dana-Farber Cancer Institute;Data;Development;Development Plans;Diabetes Mellitus;Diet;diet-induced obesity;dietary;dietary control;Disease;Endoplasmic Reticulum;energy balance;Energy Metabolism;Ensure;Environment;Epidemic;Equilibrium;Event;Exercise;Experimental Designs;Exposure to;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;follow-up;Future;Glucose;Goals;Health;Heat-Shock Proteins 70;Heat-Shock Proteins 90;High Fat Diet;Homeostasis;improved;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;Institution;Insulin Resistance;insulin sensitivity;Knockout Mice;Knowledge;Laboratories;Liver;Long-Term Effects;LoxP-flanked allele;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;medical schools;Membrane;Mentorship;Metabolic Diseases;Metabolism;Microscope;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Chaperones;Monitor;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;novel therapeutic intervention;Nuclear Proteins;Obesity;Organ;Organelles;Outcome;pandemic disease;Pathway interactions;PERK kinase;Phase;Physiology;Population;Preparation;protein complex;protein function;Protein Import;Protein Precursors;Receptor Signaling;Regulation;Regulatory Element;Research;research and development;Research Personnel;response;Risk;Role;Sampling;SARS-CoV-2 infection;Shapes;Signal Pathway;Signal Transduction;Skeletal Muscle;skills;Stress;stressor;structural biology;Students;sugar;therapeutic target;thermal stress;Thermogenesis;tool;Training;Weight Gain;Work

PROJECT_TITLE: Mechanisms of mitochondrial-ER communication during dietary and thermal induced stress

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative  Diabetes is a risk factor for cerebral ischemia and heart disease. For patients undergoing intensive therapy to manage diabetes, a major side effect is the development of low blood glucose levels (hypoglycemia). Our results indicate that exposure to recurrent hypoglycemia increases the risk of cerebral ischemia in diabetic rats. We propose to determine the mechanisms by which prior exposure to hypoglycemic episodes causes an increased risk of cerebral ischemia and cerebral ischemic damage in patients with diabetes.

PI_NAMEs: DAVE, KUNJAN R (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Accounting;Acute;American;Animal Model;Anti-diabetic Drugs;Awareness;Blood coagulation;Blood Glucose;Blood Platelets;Calcium Signaling;Cardiovascular system;Cerebral Ischemia;cerebral ischemic injury;cerebrovascular;Clinical Research;Coagulation Process;Collaborations;comparison control;Complications of Diabetes Mellitus;Development;diabetes management;Diabetes Mellitus;diabetic patient;diabetic rat;epidemiology study;Event;experience;experimental study;Exposure to;Frequencies;Functional disorder;Goals;Harvest;hazard;Health;Heart Arrest;Heart Diseases;Hematologist;Hyperglycemia;Hypoglycemia;hypoperfusion;Impairment;improved;in vivo Model;Incidence;Individual;Induced Heart Arrest;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Literature;Masks;Megakaryocytes;member;Molecular;mortality;Neurologic;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Outcome;Pathway interactions;Patients;Perfusion;Phosphatidylinositols;Phospholipids;Platelet Activation;Platelet aggregation;Platelet Aggregation Induction;Play;PLC gamma1;Predisposition;Rattus;Recurrence;Reporting;Risk;Risk Factors;Role;Severities;side effect;small hairpin RNA;Stimulus;Stroke;stroke risk;Symptoms;System;Testing;therapeutic target;Thrombosis;Thrombus;Time;transcriptome sequencing;Western Blotting

PROJECT_TITLE: Cerebral ischemia and exposure to recurrent hypoglycemia in diabetes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

ORG_CITY: SAN JOSE

ORG_NAME: TECH MUSEUM OF INNOVATION

PHR: Project Narrative Biology has become a powerful interdisciplinary and revolutionary technology, uniquely poised to transform human health and medicine, yet the majority of experiences that K-12 learners have with the life sciences are still rooted in traditional procedural and prescriptive approaches. To better prepare young people to engage in the research or applied sides of modern biomedicine, we need to engage students from a diversity of backgrounds - especially those from marginalized communities - in a 21st century approach to biology that emphasizes authentic science practices based in open-ended exploration and creativity. Our proposed project, Adapting and Scaling the Biotinkering Approach through a Community of Practice (CoP) Model, will create the community and culturally responsive types of informal learning experiences society needs to provide inspirational entry points for a more diverse next generation of biotech and biomedical innovators.

PI_NAMEs: NEALON, CAITLIN  (contact);SCHOLZE, ANJA ;WANAKULE, PRINDA

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TITLE: Adapting and Scaling the Biotinkering Approach through a CoP Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: Project Narrative Molecular knowledge on how to revert cellular aging can provide breakthrough therapies to combat diseases, such as cancers and other aging-related degenerative diseases. We obtained unique insight that telomere length – a key aging hallmark – is restricted by a nuclear organelle undergoing phase separation. By targeting phase- separation, we are developing a telomere-boosting chemical that can revert cellular aging.

PI_NAMEs: CHEN, LU  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Acute;Address;Aging;aging related;Antineoplastic Agents;Binding;carcinogenesis;Catalysis;Cell Aging;Cell Therapy;Chemicals;chimeric antigen receptor T cells;combat;cytotoxicity;Degenerative Disorder;Disease;driver mutation;Endowment;Engineering;Enzymes;exhaustion;Functional disorder;Genes;Genetic;genotoxicity;Goals;Growth;hallmarks of aging;Homeostasis;Hypermethylation;improved;insight;Knowledge;Length;Link;Location;Malignant Neoplasms;Modeling;Molecular;Monitor;Motor Neurons;Mutation;novel;Nuclear;optogenetics;Organelles;Organism;Phase;Play;promoter;protein transport;Proteins;Quality Control;Resistance;Ribonucleoproteins;RNA;RNA Conformation;RNA Splicing;RNA-Directed DNA Polymerase;Role;Small Nuclear RNA;stem cells;Structure;System;Telomerase;Telomerase inhibition;Telomerase RNA Component;telomere;Testing;tool;trafficking;Untranslated RNA;Vision

PROJECT_TITLE: Telomerase RNP Prisonbreaks from Phase-Separated Nuclear Body

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Radiation Oncology;Women's Health Research

ORG_CITY: San Diego

ORG_NAME: KINTARA THERAPEUTICS, INC.

PHR: NARRATIVE Cutaneous metastatic breast cancer (CMBC) develops in up to 24% of patients with metastatic breast cancer and has limited treatment options due to the extent and recurrence of tumors and treatment toxicity. Photodynamic therapy (PDT) uses a photo-sensitive drug (REM-001) and directed light to treat tumors with minimal effects to surrounding tissue. This trial will test a reduced dose of PDT on patients with CMBC who cannot undergo surgery or radiation therapy, to confirm that it produces therapeutic effects for their symptomatic lesions while minimizing the duration of post-treatment healing.

PI_NAMEs: BROWN, DENNIS  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: 3-Dimensional;Acute;Adverse event;Aftercare;Area;arm;associated symptom;Calibration;Clinical;Clinical Research;Cohort Studies;Common Terminology Criteria for Adverse Events;Coupled;Custom;Cutaneous;Dermal;design;Digital Photography;Dimensions;dosage;Dose;efficacy evaluation;efficacy study;Electrocardiogram;Eligibility Determination;Event;experimental study;follow-up;healing;Heart Function Tests;Hemorrhage;HIV;Hour;Image;improved;Incidence;Infection;interest;Kaposi Sarcoma;Laboratories;Lasers;Lesion;Light;light intensity;Local Therapy;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Metastatic breast cancer;minimal risk;Monitor;Myelogenous;Normal tissue morphology;objective response rate;open label;Operative Surgical Procedures;Outcome;Pain;Participant;Patients;Pharmaceutical Preparations;Phase;Phase II/III Trial;phase III trial;Photosensitivity;Photosensitizing Agents;Phototherapy;Physicians;Population;Progression-Free Survivals;Pruritus;Psoriasis;PUVA Photochemotherapy;Quality of life;Radiation therapy;Recovery;Recurrent tumor;Refractory;Relapse;Reporting;Research;Research Design;Research Personnel;response;Safety;safety study;Severities;side effect;Site;Source;Special Event;Specificity;standard of care;Standardization;Sum;symptom treatment;Symptoms;Systemic disease;Systemic Therapy;Testing;Therapeutic Effect;Therapy trial;Time;Tissues;Treatment Efficacy;treatment response;Treatment-related toxicity;tumor;Ulcer;Visit

PROJECT_TITLE: An Open-Labeled, Single Arm Phase 2 Efficacy and Safety Study of REM-001 Photodynamic Therapy (PDT) for Treatment of Cutaneous Metastatic Breast Cancer (CMBC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(11)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (Project Narrative) In LMIC, up to 20% of maternal deaths are due to suicide and in South Asia, is a leading cause of death among women of reproductive age. This research project explores engaging peer-volunteers in suicide detection and prevention in rural Pakistan, where findings will inform how task-shifted models for mental health care can successfully integrate suicide prevention practices, ultimately saving lives and improving community- based mental health services. Public health impacts may be substantial as results can be applied not only in similar South Asian contexts, but also in low-resourced settings in the US and abroad, where the suicide burden remains high.

PI_NAMEs: HAGAMAN, ASHLEY K (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;Advisory Committees;Advocacy;Age;Asia;Award;Birth;career;Cause of Death;Cessation of life;Child;Child Health;Child Rearing;Chronic;clinical care;Clinical Trials;collaborative care;Communities;community advisory board;Competence;Consolidated Framework for Implementation Research;Data;design;Detection;Disadvantaged;Early identification;Educational workshop;Enrollment;Epidemiology;Ethics;ethnographic method;Event;evidence base;Evidence based practice;experience;Family dynamics;Feeling suicidal;Funding;Future;Generations;Goals;Grant;Health;health care model;High Prevalence;implementation outcomes;implementation science;implementation strategy;improved;Individual;Infrastructure;instrument;Intervention;longitudinal analysis;Longitudinal cohort;low and middle-income countries;Manuals;maternal depression;Maternal Health;Maternal Mortality;member;Mental Depression;Mental disorders;Mental Health;mental health education;Mental Health Services;Mentors;Mentorship;Methods;Modeling;Monitor;mortality;motherhood;Mothers;National Institute of Mental Health;Outcome;Pakistan;Pattern;peer;perinatal period;pilot trial;Population;population health;pregnant;Pregnant Women;Prevention;prevention practice;Prevention Research;Prevention strategy;Prevention trial;preventive intervention;Procedures;programs;protective factors;Protocols documentation;Public Health;public health relevance;Qualifying;Recurrence;reproductive;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource-limited setting;Resources;response;Risk Factors;Role;Rural;Safety;screening;skills;South Asian;Stress;Structure;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;symposium;System;Testing;Thinking;Time;Training;transmission process;United States National Institutes of Health;Violence;volunteer;Woman;Women's mortality;Work;Workload

PROJECT_TITLE: Opportunities for suicide prevention integration into task-shifted mental health interventions in low-resourced contexts

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Neuronal loss in the locus coeruleus (LC) better predicts the onset and severity of symptoms of Alzheimer’s disease (AD) than Aβ/neurofibrillary tangles or cell loss in any other brain region. We have previously demonstrated the vulnerability of the LC to aging and stress, and our preliminary data shows faster LC- norepinephrine (NE) functional decline among blacks, possibly related to lifetime experience of discrimination. This innovative study will test whether loss of LC-NE function better predicts cognitive impairment than current ATN biomarkers, particularly among blacks, suggesting a novel approach to racial-dependent strategies for diagnosis and therapeutical interventions in AD.

PI_NAMEs: DING, YU-SHIN  (contact);OSORIO, RICARDO S

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Age;age difference;age related;age related changes;Aging;aging population;allostatic load;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid pathology;Arousal;Attention;Autopsy;Behavioral Research;Biological;Biological Markers;black men;Black Populations;Black race;Blood Vessels;Body mass index;Brain;Brain region;Brain Stem;Cell Death;Cell Density;Cell Nucleus;Cells;Cerebrospinal Fluid;cerebrovascular;Chronic;Chronic stress;Classification;Clinical;Clinical Trials;Cognition;Cognitive;Cognitive aging;cohort;Communities;Data;Dementia;Deposition;Development;Diabetes Mellitus;Diagnosis;Disadvantaged;Discrimination;Disease;Education;ethnic difference;ethnic discrimination;Exposure to;Fright;functional decline;Functional disorder;health disparity;High Prevalence;hippocampal atrophy;Hippocampus;Human;Hypertension;Image;Impaired cognition;Income;innovation;late life;locus ceruleus structure;male;Measures;Metabolic syndrome;middle age;Modeling;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neurons;noradrenaline transporter;Norepinephrine;norepinephrine system;normal aging;novel strategies;Participant;Pathology;perceived discrimination;perceived stress;Play;Positron-Emission Tomography;pre-clinical;predictive marker;Predictive Value;Predictive Value of Tests;Prevalence;Publishing;Race;racial difference;racial discrimination;racial disparity;radiotracer;Regulation;Reporting;Research;response;reuptake;Risk;Risk Marker;Role;Scanning;Severities;sex;Site;social;Social Environment;Societies;socioeconomic disadvantage;Source;Stress;stressor;Substance abuse problem;Symptoms;System;tau Proteins;Testing;Thalamic structure;Therapeutic Intervention;United States National Institutes of Health;Universities;Vascular Diseases;vascular risk factor;Washington;β-amyloid burden

PROJECT_TITLE: Brain Effects of Lifetime Racial/Ethnic Discrimination on the LC-NE Function and the Risk for Alzheimer's Disease


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tobacco

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: PROJECT NARRATIVE Lung cancer is the number one cause of cancer death in the United States and metals are a major cause of the disease. Our study focuses on how hexavalent chromium, a metal with widespread exposure known to cause lung cancer, causes chromosome instability, a hallmark event in lung cancer. Our findings will transform our understanding of how metals cause chromosome instability and lung cancer, which may spur new potential treatment targets, new approaches to reduce and prevent metal-induced lung cancer, and new insights to better determine and manage safer exposure levels for this major public health concern.

PI_NAMEs: WISE, JOHN PIERCE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3-Dimensional;Animals;Attention;Cancer Etiology;carcinogenicity;Carcinogens;Cell Line;cell type;Cells;Cessation of life;chromium hexavalent ion;Chromosomal Instability;Collection;Colon Carcinoma;Complex;Disease;Environmental Health;Epithelium;Event;Fibroblasts;Funding;Health;Heritability;Human;human subject;improved;Individual;induced pluripotent stem cell;insight;interest;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Metal Carcinogenesis;Metal exposure;Metals;Minority;mixed cell culture;Mutagens;neoplastic;Neoplastic Cell Transformation;novel;novel strategies;Outcome;Persons;Population;prevent;programs;Public Health;Risk Assessment;social stigma;stem cell model;Tobacco;Tobacco use;tobacco user;tool;Translating;United States

PROJECT_TITLE: Chromosome Instability Drives Metal-Induced Lung Cancer


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project narrative Structural models provide uniquely detailed information that is used to understand cellular processes in health and disease and to design more effective drugs. This proposal aims to advance methods for data analysis in X- ray crystallography and cryo-electron microscopy, so that currently unattainable problems of structural variability and of using electron diffraction efficiently can be solved. The development of these methods will advance thousands of structural projects each of which has individual importance for the NIH mission.

PI_NAMEs: OTWINOWSKI, ZBYSZEK  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Algorithms;Area;Biochemical;Biophysics;Cell Physiology;Cellular biology;combinatorial;comparative genomics;Complex;complex data;Cryoelectron Microscopy;Data;Data Analyses;data complexity;data mining;Data Set;design;dimension reduction;Disease;Drug Design;electron crystallography;electron diffraction;Electron Microscopy;Health;Individual;method development;Methods;Mission;Modeling;Molecular;nanocrystal;Noise;particle;Pattern;Pharmaceutical Preparations;Phase;Procedures;reconstruction;Research;Research Design;Resolution;Roentgen Rays;Sampling;segregation;Signal Transduction;single molecule;small molecule;Source;structural biology;Structural Models;Structure;Techniques;United States National Institutes of Health;Work;X-Ray Crystallography

PROJECT_TITLE: From complex data to complex structures: new methods for structural biology

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: FAYETTEVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE Cancer cachexia affects up to 80% of cancer patients and is responsible for 20-40% of cancer-related mortalities depending on type of cancer. At current efficacious therapies to prevent and attenuate the onset of cancer cachexia are lacking. The proposed studies will examine targeted approaches to the development of cancer cachexia and specific means of therapy delivery for the prevention of this condition.

PI_NAMEs: GREENE, NICHOLAS PERRY (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;Allografting;Antioxidants;Atrophic;Attenuated;attenuation;Binding;Cachexia;Cancer Cachexia;Cancer Patient;cancer prevention;cancer type;Cessation of life;chemotherapy;Clinical;clinical translation;Colorectal Cancer;Data;Depressed mood;Development;Dietary Intervention;early onset;efficacious treatment;efficacy evaluation;Event;experimental study;Fluorescein-5-isothiocyanate;Gene Transfer;Genetic;Goals;Health;Impairment;Implant;improved;In Vitro;innovation;insight;Intervention;Laboratories;Lewis Lung Carcinoma;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;mortality;Mus;Muscle;muscle form;Muscular Atrophy;Nature;network dysfunction;Nodal;novel;novel strategies;novel therapeutic intervention;OPA1 gene;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pleiotropism;Pre-Clinical Model;prevent;Prevention;Preventive;Preventive measure;protein degradation;Proteins;Public Health;Reactive Oxygen Species;Repression;Respiratory physiology;small molecule;success;System;Therapeutic;Therapeutic Agents;therapeutic development;Time;tool;Transgenic Mice;treatment strategy;tumor;Viral load measurement;virus testing;Virus-like particle;wasting;Work

PROJECT_TITLE: DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE This project will dissect the dysregulated molecular circuitry in the brains of individuals with cocaine use disorder and/or HIV infection. The proposal will identify genes in human brain that contribute to cocaine use disorder and HIV-related neurocognitive impairments. These approaches could lead to novel gene therapies to control and perhaps reverse the relentless disease state.

PI_NAMEs: CHENG, CHRISTINE  (contact);MOORE, DAVID J

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Acute;acute infection;addiction;Alcohols;antiretroviral therapy;Astrocytes;Behavior;Biological Assay;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain cell;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;cerebrovascular;chronic inflammatory disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;Cocaine misuse;cocaine use;Cocaine use disorder;Cocaine Users;Computer Analysis;Corpus striatum structure;Data Set;Databases;Development;Disease;Dorsal;Event;Exhibits;Gene Expression;gene regulatory network;gene therapy;Genes;genome-wide;glial activation;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immune;immune activation;immune cell infiltrate;Immunosuppression;In Vitro;in vivo;Incidence;Individual;Induced Neurons;Infection;Inflammation;Inflammatory;Interneurons;knock-down;Knock-in;Knock-out;Lead;Leptomeninges;Methamphetamine;Methods;Microglia;Microtubules;Modeling;Molecular;nano-string;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Neuroglia;Neurologic;Neurologic Dysfunctions;Neuronal Injury;Neurons;neurotoxicity;new technology;novel;Organoids;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;Pericytes;Persons;Pharmaceutical Preparations;Population;Prefrontal Cortex;Primary Infection;Property;Regulation;Research;resilience;response;Route;Sampling;seroconversion;single nucleus RNA-sequencing;stimulant use;Substance Use Disorder;Technology;Transcript;transcriptome;transcriptomics;Validation;Variant;Vascularization;Viral Load result;Viral reservoir

PROJECT_TITLE: Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIV


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative  Understanding how leptin modulates LepRb neurons and how these neurons control energy balance represent the long-term goals of our previous and proposed studies under this project (DK056731). We have identified several novel populations of LepRb neurons that play important roles in energy balance. We now propose to understand the regulation, function, and mechanisms of action for these LepRb neuron types, thereby identifying processes that may be targeted for the therapy of obesity.

PI_NAMEs: MYERS, MARTIN G (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adult;American;Award;Behavior;Body Weight;cell growth regulation;cell type;Cells;Communication;cost;Cues;derepression;design;Development;Diabetes Mellitus;Disease;Eating;Endocrine;energy balance;Energy Metabolism;Gene Expression;Genes;Genetic Transcription;Goals;Healthcare Systems;Hormones;Hypothalamic structure;Individual;insight;interest;Leptin;Longevity;median eminence;Mediating;Medical;Metabolic;Metabolic Diseases;Molecular;Molecular Genetics;neural;neural circuit;neuromechanism;Neurons;Neurosecretory Systems;neurotransmission;new therapeutic target;novel;Obesity;obesity treatment;Persons;Physiological;Physiology;Pituitary Hormones;Play;Population;prevent;Process;programs;Quality of life;receptor;Regulation;response;restraint;Role;Signal Pathway;single nucleus RNA-sequencing;STAT3 gene;targeted treatment;Testing;Therapeutic Intervention;tool;transcription factor;Transcriptional Activation;Work

PROJECT_TITLE: Molecular and Neural Mechanisms of Leptin Action

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


PHR: NARRATIVE The development of a highly skilled diverse workforce that will impact all aspects of health related research efforts is essential to sustain the Nation’s research priorities, scientific and economic competitiveness. The San Diego IRACDA Program will address this need by providing rigorous training in research, teaching and critical academic skills to a diverse group of postdoctoral scholars who will seek independent research and teaching careers in academia. The San Diego IRACDA Program will also enrich the science curriculum, improve teaching and learning at two large Hispanic-serving institutions in the San Diego area and provide critical mentoring and research experiences for underrepresented students that will enhance the training of the next generation of scientists.

PI_NAMEs: TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Award;Biomedical Research;biomedical scientist;California;career;career development;Cities;Clinical;college;Educational Curriculum;Educational process of instructing;Ethnic Population;evidence base;Evidence based practice;experience;Faculty;Fellowship;Funding;Goals;Grant;Health;Healthcare;improved;innovation;Institution;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;next generation;Population;Positioning Attribute;Postdoctoral Fellow;Professional Competence;Program Evaluation;programs;Publishing;racial population;recruit;Reproducibility;Research;role model;Scholars Program;Science;Scientist;skill acquisition;student participation;Students;tenure track;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: San Diego IRACDA Scholars Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Regenerative Medicine

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: Project Narrative The genetic regulation of the shape and size of internal organs and whole body is crucial during development, regeneration, and homeostasis. This project will develop a novel integrated systems biology approach to elucidate mechanistically the molecular pathways and their coordination that control large-scale tissue growth dynamics in living organisms. These advancements will have a broad impact on our understanding of human development and regeneration towards novel therapeutic interventions for treating birth defects, traumatic injuries, and cancer.

PI_NAMEs: LOBO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Amputation;Animals;Biological Assay;biophysical model;biophysical properties;Biophysics;Cell Adhesion Molecules;Complex;computer framework;Congenital Abnormality;Data;Data Set;Development;experimental study;Gene Expression;Gene Expression Regulation;gene regulatory network;Genetic;genetic manipulation;Goals;Growth;Homeostasis;Human;Human Development;Image;In Situ Hybridization;in vivo;Machine Learning;machine learning method;Malignant Neoplasms;mathematical learning;mathematical model;Mathematics;Medicine;Methods;Modeling;Molecular;Morphology;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Ontology;Operative Surgical Procedures;Organ;Organism;Outcome;Pathway interactions;Planarians;Process;regenerative;Regenerative capacity;Regulation;RNA Interference;Shapes;simulation;Systems Biology;Tissues;Traumatic injury;Work

PROJECT_TITLE: Systems Biology of Shape and Size Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE While great strides have been made in the diagnosis and treatment of pediatric cancers, much remains to be done. The cure of children with cancer is often achieved with unacceptable side-effects, and for many cancer subtypes of pediatric cancer, current therapy is inadequate. The best hope for reducing the burden of pediatric cancer is the training of committed researchers by an experienced and accomplished faculty that is involved in diverse aspects of basic and clinical research directly relevant to tackling these challenging problems in children.

PI_NAMEs: ARMSTRONG, SCOTT A (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Pediatric Oncology;Research Training

PROJECT_TITLE: Research Training in Pediatric Oncology

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


PHR: Project Narrative Long noncoding RNAs (lncRNAs) are a poorly understood class of genes that are subject to frequent deregulation in lung adenocarcinoma, suggesting a potential wealth of unexplored therapeutic targets. We have developed innovative approaches to model the aberrant expression of lncRNA in cell and animal models of lung adenocarcinoma, providing a unique opportunity to study the contributions of lncRNAs to the development and treatment of this aggressive disease.

PI_NAMEs: DIMITROVA, NADYA M (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Animal Model;Animals;Binding Proteins;Bioinformatics;Biology;Cell Line;Cell model;Cells;Chemicals;Chromatin;cohort;Collaborations;conditional knockout;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;cytokine;design;Development;differential expression;Disease;Disease Progression;Dissociation;Dominant-Negative Mutation;Down-Regulation;Doxycycline;Effectiveness;Event;experimental study;feasibility testing;gain of function;Gene Expression;Genes;Genetic Models;Genetic Transcription;Germ Lines;Goals;Human;Inflammatory;innovation;Knock-out;KRAS2 gene;Lung Adenocarcinoma;MALAT1 gene;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;Molecular Biology;mouse model;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;overexpression;patient prognosis;Patients;pleiotropism;posttranscriptional;Predisposition;Prognosis;programs;Regulation;RNA Splicing;Role;Series;Signal Transduction;System;Technology;Testing;Therapeutic;therapeutic target;Time;TP53 gene;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Deregulation of long noncoding RNAs in cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities

PHR: Public Health Relevance/Narrative Significant MRI scanner-dependent bias in diffusion acquisition inadvertently corrupts derived tissue diffusivity metrics increasing likelihood of false findings and inflating cost for multi-center clinical oncology trials employing this noninvasive quantitative imaging technology. The goal of the proposed renewal academic industrial partnership is to integrate bias correction tools developed during the parent project into ongoing clinical oncology trials to eliminate cross-scanner variability errors and improve accuracy of diffusivity-based cancer biomarkers. Ultimately, this will advance diagnostic, prognostic and treatment monitoring based on quantitative diffusion imaging toward more effective clinical management of cancer patients.

PI_NAMEs: MALYARENKO, DARIYA I. (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Address;Adoption;Agreement;American College of Radiology Imaging Network;Benchmarking;Biological;Bone Marrow;Breast;California;cancer biomarkers;cancer clinical trial;Cancer Detection;cancer imaging;Cancer Patient;Clinical;clinical application;clinical decision-making;clinical imaging;Clinical Management;Clinical Trials;Clinical Trials Cooperative Group;cohort;Collaborations;Complex;cost;Data;design;Detection;Development;Diagnosis;Diagnostic;Diffusion;Early treatment;Engineering;Ensure;flexibility;Generations;Goals;Head and neck structure;Image;image registration;imaging capabilities;imaging facilities;imaging platform;Imaging technology;improved;Industrialization;industry partner;Institution;Left;Lesion;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;Maps;Memorial Sloan-Kettering Cancer Center;Michigan;Modeling;Monitor;Multi-Institutional Clinical Trial;Oncology;oncology trial;Organ;Output;parent project;Parents;Pathology;Patients;Performance;Prediction of Response to Therapy;Procedures;prognostic;prospective;Protocols documentation;prototype;public health relevance;quantitative imaging;Radiation;Radiology Specialty;Reproducibility;Research;Research Personnel;Route;San Francisco;Scanning;Scientist;Site;Source;Standardization;success;System;Systematic Bias;Technology;Testing;Therapeutic;Tissue Model;Tissues;tool;translational cancer research;translational oncology;Translations;treatment response;tumor;Universities;Variant;Vendor;Washington

PROJECT_TITLE: Correction of Diffusion Gradient Bias in Quantitative Diffusivity Metrics for MultiPlatform Clinical Oncology Trials


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Kidney Disease;Neurodegenerative;Rare Diseases

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Light chain amyloidosis is a complex disease involving both the clonal expansion of a diseased plasma cell and the toxic deposition of destabilized, amyloidogenic immunoglobulin light chains as toxic oligomers and amyloid fibrils on peripheral target tissues such as the kidney and heart. Current treatments for light chain amyloidosis use chemotherapeutics to ablate the underlying diseased plasma cell population; however, a large population of patients are too sick from severe amyloid pathology on the kidney or heart to tolerate chemotherapy, necessitating the development of new strategies to reduce amyloid toxicity and improve peripheral target tissue function to treat this patient population. Here, we are establishing new multi-tissue strategies that reduce peripheral immunoglobulin light chain toxicity to provide new opportunities to reduce kidney and heart toxicity and allow chemotherapeutic access to the underlying diseased plasma cells in this currently untreatable patient population.

PI_NAMEs: WISEMAN, ROCKLAND LUKE (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Ablation;Address;Amyloid;Amyloid Fibrils;amyloid pathology;Amyloidosis;analog;Antioxidants;arm;ATF6 gene;Attenuated;Autologous Stem Cell Transplantation;Award;Cardiac;Cardiac Myocytes;Cell secretion;Cells;Cessation of life;chemotherapy;Clonal Expansion;Complex;Deposition;Development;Disease;Endoplasmic Reticulum;Epithelial Cells;Funding;Gene Expression Profile;Genes;Goals;Heart;heart cell;improved;In Vitro;in vivo;Injury;Kidney;kidney cell;Light;Light-Chain Immunoglobulins;Modeling;Molecular;Monitor;mouse model;next generation;Organ;Oxidative Stress;Pathogenesis;patient population;Patients;Peripheral;Peripheral Resistance;pharmacologic;Phototherapy;Plasma Cells;Population;primary amyloidosis of light chain type;Primary Cell Cultures;Proteins;proteostasis;Regulation;renal epithelium;response;Serum;small molecule;Stress;Testing;Therapeutic;Tissues;Toxic effect;transcription factor;translational potential

PROJECT_TITLE: Establishing Strategies to Ameliorate Amyloid Pathology in Light Chain Amyloidosis

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Cutaneous lupus erythematosus significantly impacts patients' quality of life, socioeconomic status, and can result in permanent scarring and dyspigmentation. However, our current understanding of CLE pathogenesis is limited, making the development of targeted therapies difficult. This proposal aims to investigate how immune cells respond to inflammatory signals in the context CLE, and in turn, to leverage this information to develop targeted therapies to treat CLE.

PI_NAMEs: HO, ALLEN WAYNE (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Ablation;Activities of Daily Living;Address;Affect;Animal Model;Attention;Autoimmune;Autoimmune Diseases;Automobile Driving;Biology;career development;CD4 Positive T Lymphocytes;Cells;Cellular biology;Cellular Immunology;Characteristics;Cicatrix;Clinical;Colitis;Cutaneous;Cutaneous Involvement;Cutaneous Lupus Erythematosus;cytokine;Data;Data Set;Dermatology;Development;differentiation in vitro;Disease;effective therapy;experience;experimental study;Genes;Genetic Transcription;Genomics;Homeostasis;Hospitals;IL17 gene;Immune;Immunologics;improved;Inflammation;Inflammatory;instructor;Interferon Type II;Interleukin-12;interleukin-21;interleukin-23;Intestines;Investigation;Laboratories;Lupus;lupus cutaneous;Lupus Erythematosus;Maintenance;Mediating;medical schools;Mentors;Molecular;Molecular Immunology;mouse model;Mus;novel;optimal treatments;Organ;Pathogenesis;Pathogenicity;Patient Care;Patients;Phenotype;Physicians;Play;Population;Positioning Attribute;Production;Program Development;Protocols documentation;Quality of life;receptor;receptor expression;receptor function;Receptor Signaling;Research;Role;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Skin;skin disorder;Socioeconomic Status;Study models;systemic autoimmune disease;Systemic disease;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Technology;Testing;Th1 Cells;therapeutic target;Time;Tissues;Treatment Protocols;whole genome;Woman;Work

PROJECT_TITLE: Mechanisms of IL-23 receptor-mediated pathogenicity in CD4+ T cells

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Substance use and substance use disorders (SUD) have significant adverse health and social effects, generate considerable costs to the healthcare system and society, and are among of the most critical public health concerns in the United States. However, the identification, assessment, and treatment of patients with substance use and SUD are very sub-optimal in general medical settings (e.g., primary care, emergency departments, adolescent medicine, obstetrics/gynecology), where the majority of such patients are seen. The University of Pittsburgh Collaboration in Addiction Training Scholars (PittCATS) Program will support promising junior faculty for 3-5 years, provide them with comprehensive mentored career development experiences, and launch them on productive careers as independent investigators and leaders in substance use and SUD research in general medical settings.

PI_NAMEs: LIEBSCHUTZ, JANE M (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Advisory Committees;Applications Grants;Award;career;Career Choice;career development;Clinical;Clinical Research;Clinical Sciences;Collaborations;Competence;Development;Development Plans;Discipline;Doctor of Pharmacy;Doctor of Philosophy;education research;Educational process of instructing;Ensure;Evaluation;experience;Faculty;Funding;Goals;Grant;Information Dissemination;Leadership;Measures;Medical;Mentors;Motivation;multidisciplinary;Outcome;Paper;Patient Care;Patients;Peer Review;post-doctoral training;programs;Public Health;Publications;Qualifying;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Scholars Program;Scientist;skills;substance use;Substance Use Disorder;success;tool;Training;Training Activity;Training Programs;Translational Research;United States;Universities;University resources


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The PACRT continues to have a clearly defined and unique direction among HIV T32 programs, with its focus on clinical outcomes research, and how that research interfaces with translational research, clinical trials, and health policy. The program plays a crucial role in training the next generation of highly successful investigators to address the complex and evolving issues arising today in HIV clinical research.

PI_NAMEs: SIEDNER, MARK J (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Clinical Research;programs;Research Training

PROJECT_TITLE: Program for AIDS Clinical Research Training (PACRT)

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BOGDAN, RYAN H;ROGERS, CYNTHIA ELISE (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 23/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Telehealth

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: Project Narrative This study will examine major changes in methadone treatment delivery that occurred following COVID-19, and will evaluate the impact of COVID-driven regulatory exemptions that expanded take-home methadone and telehealth counseling in Opioid Treatment Programs. The study will provide novel empirical data to guide regulatory reform and patient care, and is poised to have high public health impact.

PI_NAMEs: GRYCZYNSKI, JAN  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Adherence;Administrator;Admission activity;advanced analytics;Affect;analytical method;Area;Behavioral;behavioral health;care delivery;care seeking;Cessation of life;Clinic;Clinical;combat;Coronavirus;Counseling;COVID-19;COVID-19 impact;COVID-19 pandemic;Crowding;Data;Death Records;Decision Making;Disparity;Dose;Dropout;drug testing;Drug usage;effective therapy;Eligibility Determination;Equity;Ethnic Origin;Frequencies;Goals;Health Benefit;health equity;health practice;Health Services;Health Services Accessibility;Healthcare Systems;Home;indexing;Individual;Interruption;Link;Medicine;Methadone;methadone treatment;Methods;Modeling;models and simulation;Monitor;mortality;novel;opiate tolerance;Opioid;opioid mortality;opioid overdose;opioid treatment program;opioid use disorder;Outcome;Outpatients;Overdose;overdose death;overdose risk;Pain;Patient Care;Patient Monitoring;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Policies;Population;Positioning Attribute;post-COVID-19;predictive modeling;premature;Provider;Public Health;public health emergency;Qualifying;Race;Regulation;Relapse;Relaxation;Research;response;Risk;risk mitigation;Series;service delivery;sex;Shapes;Structure;System;telehealth;Time;transmission process;Travel;treatment response;trend;United States Substance Abuse and Mental Health Services Administration;willingness

PROJECT_TITLE: Scope and impact of methadone take-home and telehealth practice changes during the COVID-19 pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Frontotemporal lobar degeneration with TAR DNA-binding ~43kDa (TDP-43) inclusions (FTLD-TDP) and amyotrophic lateral sclerosis (ALS) share common pathological features but can present with heterogeneous clinical features including dementia (FTLD-TDP), motor neuron dysfunction (ALS), or both (ALS-FTD). The overall aim of this proposal is to leverage genotype and transcriptomic approaches to understand the underlying molecular mechanisms that contribute to the observed clinical heterogeneity across these sporadic TDP-43 proteinopathies. Disentangling this heterogeneity may help inform the development of therapeutic targets to attenuate the course of these devastating neurodegenerative diseases.

PI_NAMEs: SPENCER, BARBARA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Attenuated;Automobile Driving;Autopsy;Behavioral;behavioral impairment;Bioinformatics;Biological;Brain region;C9ORF72;case control;causal variant;cell type;Characteristics;Clinical;clinical heterogeneity;clinical translation;Cognitive;Complex;Data;Dementia;Development;differential expression;digital;Disease;disorder risk;Disparate;DNA Binding;DNA Sequence Alteration;experience;Family;Foundations;frontal lobe;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;functional genomics;Gene Expression;Genes;Genetic;genetic association;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genomic locus;Genomics;Genotype;Heterogeneity;Immunohistochemistry;Impaired cognition;Individual;insight;Link;Measures;Mentorship;Molecular;Motor Cortex;Motor Neurons;Mutation;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;neuromuscular;Neuronal Dysfunction;neuropathology;novel;novel strategies;Pathologic;Pathology;Pattern;Phenotype;polygenic risk score;Predisposition;protein TDP-43;Quantitative Trait Loci;regional difference;Research;Risk;risk variant;Sampling;Signal Transduction;Single Nucleotide Polymorphism;statistics;superoxide dismutase 1;Syndrome;Temporal Lobe;Testing;therapeutic development;therapeutic target;Tissue Sample;Tissue-Specific Gene Expression;Tissues;Training;trait;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Variant;Weight;Work

PROJECT_TITLE: Shared and disparate genomic features of TDP-43 proteinopathies


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The goal of the Medical Scientist Training Program at Columbia University's Vagelos College of Physicians and Surgeons is to provide outstanding training in rigorous, responsible biomedical research that will benefit human health, integrated with exceptional training in modern principles and ethical practice of medicine and patient care. A longstanding challenge for modern medical practice is rapidly applying cutting-edge scientific discoveries into better diagnosis and treatments for patients. Training contemporary clinician-scientists in a highly integrated MD-PhD dual-degree program that places great emphasis on diversifying the trainee pool and retaining program graduates into long-term research careers would, therefore, be of substantial benefit to the health and well-being of the nation's populations.

PI_NAMEs: REINER, STEVEN L (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Our training program in human genetics offers pre-doctoral students the opportunity to learn and apply human genetics science in a highly collaborative and collegial environment rich in resources that can stimulate human genetics research. BioVU, the biobank at Vanderbilt University, for example, has more than 250,000 subjects and past human genetics students have been unusually productive because of the opportunities in conducting human genetic studies in these data. Our students receive a broad-based education and have traditionally pursued a wide range of research in human genetics and professional careers.

PI_NAMEs: COX, NANCY J;SAMUELS, DAVID C (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Training Program on Genetic Variation and Human Phenotypes

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Liver fibrosis and subsequent cirrhosis are a leading cause of mortality in the US and worldwide. This application aims to uncover the role of cell metabolism on the amplification of liver fibrosis and to target this mechanism in preclinical studies. Thus, it has the potential to identify new therapeutic strategies to treat humans with advanced liver fibrosis and cirrhosis.

PI_NAMEs: KOSTALLARI, ENIS  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;AGFG1 gene;Animal Model;Bar Codes;Biological Assay;Cell membrane;Cell model;Cellular Metabolic Process;Cirrhosis;Data;Development;Disease;effective therapy;Epigenetic Process;epigenetic regulation;extracellular vesicles;Fibrosis;Gene Expression;Genes;Genetic Transcription;Genus Hippocampus;glucose metabolism;Glycolysis;Glycolysis Inhibition;Hepatic Stellate Cell;Hexokinase 2;Histones;Human;In Vitro;in vivo;innovation;Knowledge;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver transplantation;Lysine;Mediating;Metabolic;Modeling;mortality;Mus;nanoflow cytometry;novel;novel therapeutic intervention;Outcome;Pathologic;pharmacologic;Phosphorylation;Phosphotransferases;Platelet-Derived Growth Factor B;Play;preclinical study;programs;Promoter Regions;Proteins;RAS Superfamily Proteins;Regulation;Research;Research Proposals;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SLC2A1 gene;Spatial Distribution;Technology;Testing;Therapeutic;trafficking;Transcriptional Activation;transcriptomics;treatment strategy;Up-Regulation;Vesicle;vesicular release;Work

PROJECT_TITLE: Pathobiology of liver fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]