NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: TAN, DEREK S (contact)

PROJECT_TERMS: Address;analog;anti-cancer;anti-cancer research;ARNT gene;Automobile Driving;bHLH-PAS factor HLF;Binding;Biochemistry;Biological Assay;Biology;Biophysics;Breast;Cancer Etiology;Cells;Cellular Assay;Cessation of life;Chemicals;Chronic;Clear cell renal cell carcinoma;Clinical Trials;cofactor;Collaborations;Colorectal;Community Outreach;Complex;Coupled;Cryoelectron Microscopy;Data;Death Rate;Development;Dimerization;Disparity in diagnosis;Education and Outreach;education research;Elements;Etiology;Exhibits;experience;FDA approved;Gene Expression;Genetic Transcription;Helix-Turn-Helix Motifs;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;improved;In Vitro;in vitro Model;Individual;inhibitor;innovation;insight;Link;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;men;Methods;Modeling;Molecular;neurogenesis;novel;Organic Chemistry;overexpression;Pathway interactions;patient population;Pharmaceutical Chemistry;pharmacologic;Play;Point Mutation;preclinical evaluation;Predisposition;programmed cell death protein 1;Property;Prostate;Protein Binding Domain;Protein Isoforms;Proteins;racial disparity;Regulation;Renal Carcinoma;Research;response;Roentgen Rays;Role;Route;Sensory;Series;single-minded protein;small molecule;small molecule inhibitor;Solid Neoplasm;structural biology;Structural Models;Structure;Therapeutic;tool;training opportunity;Transcription Coactivator;transcription factor;tumor;Tyrosine Kinase Inhibitor;Work;Xenobiotics

PROJECT_TITLE: Full Project 1: Structural, chemical, and cellular probing of a new anticancer target: HIF-coactivator complexes


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Patient Safety;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PI_NAMEs: SHAH, NEIL J (contact)

PROJECT_TERMS: 2 arm randomized control trial;Address;Adverse event;Affect;Age;Albumins;allostatic load;anti-cancer;anti-cancer research;Area;arm;Artificial Intelligence;Autoimmune Diseases;B-Lymphocytes;Biological;Biological Factors;Blood;Blood Pressure;Body mass index;cancer care;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Cardiac;Caring;CD80 gene;CD86 gene;CD8B1 gene;Clinical;clinical phenotype;cohort;community building;Community Outreach;community research;Counseling;Creatinine;Cutaneous;cytokine;Data;deprivation;Development;Diastolic blood pressure;DRB Gene;Education and Outreach;Electronic Health Record;Employment Status;Enrollment;eosinophil;Equity;ethnic identity;Event;Female;Food;Foundations;FOXP3 gene;Future;Gender;Genetic;Glucose;Goals;Grant;group intervention;Health Services Accessibility;Heart Rate;Hematology;Hemoglobin concentration result;Homing;Housing;Human Resources;Immune;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunobiology;Immunologic Markers;Immunooncology;Immunotherapy;improved;Incidence;Income;indexing;Individual;Inflammatory;Insurance;Intervention;Language;Lead;Life Expectancy;Life Stress;Linguistics;low socioeconomic status;Managed Care;Measures;Memorial Sloan-Kettering Cancer Center;Metabolic;Methods;Minority;Minority Enrollment;Minority Groups;minority patient;Morbidity - disease rate;mortality;National Health Interview Survey;Non-Small-Cell Lung Carcinoma;Organ;Outcome;Pathway interactions;patient engagement;patient navigation;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;PhenX Toolkit;Plasmablast;Population;primary outcome;programs;Progression-Free Survivals;Quality of life;Race;Randomized, Controlled Trials;Regimen;Regulatory T-Lymphocyte;Research;research study;Resource Sharing;Risk;safety net;secondary outcome;Serum;Severities;side effect;Skin;Skin Tissue;social health determinants;Specimen;student mentoring;Supportive care;Surveys;Symptoms;T-Lymphocyte;Testing;translational health science;Transportation;treatment duration;treatment stratification;Treatment-Related Cancer;triple-negative invasive breast carcinoma;United States National Institutes of Health;White Blood Cell Count procedure;Work;working group;World Health Organization

PROJECT_TITLE: Full Project 2: I CARE (Immunotherapy Cutaneous Adverse events REsearch)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (A1)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GANY, FRANCESCA M (contact)

PROJECT_TERMS: Address;Administrator;Adverse event;Analgesics;anti-cancer research;Appointment;Area;Artificial Intelligence;Businesses;cancer health disparity;cancer site;Certification;Chinese;Cities;Clinical;clinically significant;college;Communication;Communities;Community Outreach;comparative;Complex;Data;Diagnosis;Disease;Education and Outreach;Engineering;Equity;evidence base;Expert Systems;Face;Funding;Future;Genetic Transcription;Geography;Goals;health care quality;health care settings;health equity;Health Policy;Healthcare Systems;Human;Immigrant;improved;improved outcome;Individual;Insurance;Intervention;Language;Legal;Limited English Proficiency;Linguistics;Literature;Malignant Neoplasms;Medical;Medical Oncology;member;Memorial Sloan-Kettering Cancer Center;Methods;Modality;Modernization;New York;New York City;Oncology;Outcome;outcome disparities;Patients;Persons;Pilot Projects;Play;Population;primary outcome;programs;Provider;Randomized;Randomized, Controlled Trials;Resource Sharing;Resources;Role;Running;Schools;Screening for cancer;secondary outcome;Serious Adverse Event;service delivery;Service provision;Services;simulation;Site;Spanish;Strategic Planning;Students;Surveys;symposium;System;Technology;tool;Training;Translating;undergraduate student;United States National Institutes of Health;Visit;working group;Writing

PROJECT_TITLE: Pilot Project 1: AI HEALS (Health Equity Advances through Language Solutions)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: ZHANG, JIAN  (contact)

PROJECT_TERMS: actionable mutation;African;African American;African American population;African ancestry;anti-cancer research;Asian ancestry;Automobile Driving;Biological Markers;Biometry;cancer care;Cancer Diagnostics;Cancer Etiology;cancer genome;cancer genomics;Cancer Patient;cancer survival;cancer therapy;Cessation of life;Clinical;Clinical Data;Clinical Research;Clinical Trials;clinically actionable;clinically relevant;cohort;Cohort Studies;Community Outreach;Complex;Computing Methodologies;Consumption;Data;data mining;data pipeline;Diagnostic tests;DNA Sequence Alteration;driver mutation;East Asian;Education and Outreach;electronic health data;Electronic Health Record;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidermal Growth Factor Receptor;European;European ancestry;Future;Genetic;genomic profiles;Genomics;Germ Lines;health data;health disparity;Immune;Immune checkpoint inhibitor;Immunologic Markers;Immunology;Immunotherapy;improved;Income;Induced Mutation;Inflammation Mediators;innovation;insight;Insurance;Joints;Knowledge;KRAS2 gene;large language model;Light;Link;Malignant neoplasm of lung;Manuals;Measures;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;Mutagenesis;mutant;Mutation;Native American Ancestry;never smoker;next generation sequencing;non-genetic;non-smoker;Outcome;outcome prediction;patient population;Patient Self-Report;Patients;Pilot Projects;Plasma;Population;precision medicine;Process;Race;racial disparity;response;Rural;Sampling;small molecule inhibitor;Smoker;Smoking;smoking exposure;Smoking History;Smoking Status;social factors;social health determinants;Somatic Mutation;Testing;Text;Therapeutic;therapeutic target;Time;Tobacco smoking behavior;TP53 gene;tumor;urban setting

PROJECT_TITLE: Pilot Project 2: Comprehensive characterization of somatic-environment and somatic-immune interactions in lung cancer patients with African ancestry


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Dissemination and Implementation Research

PI_NAMEs: AHLES, TIM ALAN (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Collaborations;Communities;Community Outreach;community partnership;Data;Decision Making;Development;Education;Education and Outreach;education research;Ensure;Evaluation;Faculty;Funding;Goals;Grant;Health equity research;Institution;Linguistics;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;Methods;Mission;Monitor;Needs Assessment;programs;Publications;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;Robin bird;Strategic Planning;Students;translational cancer research;translational health science;Work

PROJECT_TITLE: Planning & Evaluation Core (PEC)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: HRICAK, HEDVIG  (contact)

PROJECT_TERMS: Academic advising;Address;anti-cancer research;Area;Artificial Intelligence;Awareness;Basic Science;Behavioral;Behavioral Research;Biological;Biomedical Engineering;Biomedical Research;Cancer Biology;cancer health disparity;Cancer health equity;Cancer Research Project;career;Career Choice;career development;Career Mobility;Clinical;Collaborations;Communities;Community Outreach;community partnership;Complement;Data Analyses;Data Science;Decision Making;design;Development;Doctor of Philosophy;Education;Education and Outreach;Education Projects;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Engineering;Enrollment;Ensure;Evaluation;experience;Face;Faculty;First Generation College Students;Funding;Future;Genomics;Goals;graduate student;Grant;hands on research;health equity;Health equity research;Immigrant family;improved;innovation;innovative technologies;Institutionalization;Knowledge;Language;Leadership;Learning;Linguistics;Literature;Machine Learning;Malignant Neoplasms;Manuscripts;Medical;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Minor;Modernization;Monitor;Nanotechnology;novel strategies;Outcome;Performance;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;prevent;Privatization;Procedures;Process;programs;Research;Research Design;Research Personnel;Research Training;Resource Development;Resource Sharing;Resources;Schools;Series;Services;skills;social determinants;Socialization;socioeconomic disadvantage;Strategic Planning;student mentoring;student participation;student training;Students;success;Therapeutic;Training;Training and Education;training opportunity;translational cancer research;translational engagement;Translational Research;Translations;undergraduate student;Underrepresented Students;underserved community;underserved students;United States National Institutes of Health;Vocational Guidance;Writing

PROJECT_TITLE: Research Education Core (REC)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Precision Medicine;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LENG, JENNIFER CF (contact)

PROJECT_TERMS: Address;African;anti-cancer research;Area;Black race;Breast;Cancer Center Support Grant;cancer genomics;cancer health disparity;cancer prevention;cancer risk;Caring;Cervical;Chinese;clinical practice;Collaborations;Colorectal;Communities;community academic partnership;community engaged approach;community engagement;Community Outreach;community partnership;community setting;Data;Diagnosis;Diet;Disparity;disparity reduction;Dissemination and Implementation;Early Diagnosis;economic determinant;Education;Education and Outreach;education research;evidence base;Evidence based practice;Face;Faith;Federally Qualified Health Center;Foundations;Funding;Genetic;Genetic Screening;Grant;Head and Neck Cancer;Health;health determinants;health disparity populations;Health system;Healthcare Systems;Home;Hospitals;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immigrant;Immigrant community;Immunotherapy;improved;Incidence;individualized prevention;Infrastructure;Jamaica;Knowledge;Latino;Linguistics;Link;liquid biopsy;low socioeconomic status;Lung;Malignant Neoplasms;Medical center;medical schools;Medicine;Memorial Sloan-Kettering Cancer Center;Mexican;Minority;Mobile Health Units;Modeling;Municipalities;Needs Assessment;New York;New York City;Obesity;Occupational Groups;Occupations;Outcome;outreach;patient navigation;Patients;Persons;Physical activity;Policies;Policy Developments;Population;Population Heterogeneity;practice setting;precision cancer prevention;precision medicine;Prevention;program dissemination;programs;Prostate;Public Health;Quality of Care;Recommendation;Research;Research Personnel;Resource Sharing;Risk;Risk Reduction;safety net;screening;screening guidelines;Site;socioeconomics;South Asian;stem;Students;System;targeted treatment;Tobacco;Training;Training Activity;Translating;Translations;United States;uptake;Work;working group

PROJECT_TITLE: Outreach Core (PCORE)


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Disparities continue to persist across sexual orientation, gender identity, and region for people living with HIV (PLWH). Some of the highest rates of HIV are among sexual and gender diverse (SGD) people, a high risk group for developing anal cancer, in the U.S. South. In efforts to increase anal cancer screening among SGD PLWH in Georgia, the proposed supplement seeks to explore the phenomenon between HIV-related stigma, perceived social support, and cancer prevention behaviors among this vulnerable HIV population.

PI_NAMEs: WELLS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Affect;anal pap smear;antiretroviral therapy;Anus;Area;Attitude;Award;Behavior;Behavioral;Birth;Bisexual;Black race;cancer diagnosis;cancer prevention;cancer risk;career development;Caring;Characteristics;Chi-Square Tests;cisgender;Clinic;Clinical;Code;Communicable Diseases;Communities;Confidence Intervals;Data;Data Analyses;data cleaning;demographics;Diagnosis;Disparity;editorial;Emotional;Ethnic Origin;experience;Exposure to;Fellowship;Focus Groups;follow-up;Frequencies;Gays;Gender;gender diverse;Gender Identity;Health;health inequalities;Health Personnel;Health Promotion;Healthcare Systems;Heterosexuals;high risk population;HIV;HIV diagnosis;HIV disparities;HIV Seropositivity;Human Papillomavirus;improved;Incidence;Individual;Infection;Knowledge;Link;Logistic Regressions;Love;Malignant neoplasm of anus;Malignant Neoplasms;Manuscripts;Mediation;men;Modeling;Monitor;mortality;Odds Ratio;Outcome;Parents;Participant;Patient Self-Report;Patients;Peer Review;peer support;Personal Satisfaction;Persons;Population;population health;Population Heterogeneity;pre-doctoral;Process;Protocols documentation;psychologic;Published Comment;Publishing;Quality of life;Race;Rank-Sum Tests;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Risk Factors;role model;Sample Size;screening disparities;Screening for cancer;Screening Result;Services;sex assigned;Sex Orientation;Sexual Partners;Side;Site;skills;social;social health determinants;Social isolation;Social Network;social relationships;social stigma;Social support;sociodemographics;Specialist;Statistical Data Interpretation;statistics;Structure;substance misuse;symposium;System;Tail;Testing;Training;transgender men;University resources;Woman;Writing

PROJECT_TITLE: Exploring Stigma, Social Support, and Cancer Screenings among Sexual and Gender Diverse People Living with HIV in Georgia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Patient Safety;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Those with intellectual and developmental disabilities (IDD) have been designated by the NIH as a population with health disparities, reflected in increased morbidity and mortality rates, barriers to high quality care, stigma, biases, and ableism, and there is a gap in the literature about approaches for reducing health disparities in this population. We propose utilizing novel methods, including the creation of IDD patient risk profiles by including high risk combinations of comorbidities, social determinants of health, and IDD diagnoses, and then quantifying the association of nursing resource factors on the risk adjusted outcome of adult patients with IDD. The long- term goal is to reduce health disparities for IDD hospital patients through the appropriate deployment of nursing resources and the use of risk profiles.

PI_NAMEs: MCHUGH, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: ableism;acute care;addiction;Adult;Behavior;burnout;Cardiovascular Diseases;Care given by nurses;Caregivers;Caring;Child;Chronic Disease;Clinical;Clinical Nursing;clinical risk;cognitive skill;Communication;comorbidity;Complex;Data;Databases;Death Rate;Dementia;Developmental Disabilities;Diabetes Mellitus;Diagnosis;Diagnostic;Disability outcome;disability payment;disability risk;Disabled Persons;Disadvantaged;Discipline of Nursing;Disparity;disparity reduction;experience;Face;Family Caregiver;General Population;Goals;Health;health care availability;health disparity;health disparity populations;health equity;Healthcare;high risk;hospital readmission;Hospitalization;Hospitals;improved;Incidence;Individual;Inpatients;Intellectual functioning disability;Interdisciplinary Communication;Investments;knowledge base;Length of Stay;Literature;Low income;Machine Learning;marginalization;Mediation;Medical;Mental disorders;Methods;Mission;Modeling;Morbidity - disease rate;mortality;National Institute of Nursing Research;Neighborhoods;novel;Nurses;Nursing Education;Nursing Staff;Obesity;opioid use disorder;Outcome;outcome disparities;parent grant;Parents;Pathway interactions;Patient Care;patient population;Patient risk;patient safety;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Policies;Population;pressure;Preventive care;Process;professional atmosphere;Provider;Psyche structure;Quality of Care;readmission rates;Reduce health disparities;Research;Research Methodology;Resources;Risk;Risk Adjustment;risk stratification;Safety;severe mental illness;social;social determinants;social disparities;social health determinants;social stigma;sociodemographics;Specific qualifier value;Surveys;Symptoms;System;systematic review;Time;Training and Education;United States National Institutes of Health;Variant;Vulnerable Populations

PROJECT_TITLE: Multilevel Panel Study of Effects of Changes in Nursing on Health Equity and Patient Outcomes

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLUMBIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This proposal aims to develop an injectable bioengineering system to regenerate alveolar bone that is lost horizontally due to periodontitis. Completion of this project will help build up a novel treatment modality for horizontal alveolar bone loss in periodontitis; therefore, improve the health of millions of people in USA.

PI_NAMEs: LIU, XIAOHUA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Affinity;aged;Alveolar;alveolar bone;Alveolar Bone Loss;Animals;Anti-Bacterial Agents;Area;Attention;Biocompatible Materials;Biological;Biomedical Engineering;bone;bone loss;bone marrow mesenchymal stem cell;Bone Regeneration;Bone Resorption;Cell Adhesion;cell type;Cells;Chemical Structure;Clinic;Clinical;clinical application;Clinical Trials;clinically significant;Data;Defect;Dental;Dental Enamel;design;Development;Engineering;Epithelium;Evaluation;experimental study;Extracellular Matrix;Fibroblasts;Future;Gingiva;Goals;Health;improved;In Situ;In Vitro;in vitro Assay;in vivo;Injectable;innovation;Mandible;mechanical properties;Mechanics;Membrane;Mesenchymal Stem Cells;Microfabrication;Microspheres;Modality;Modeling;Modification;Morphology;Mouth Diseases;Mus;nanofabrication;nanofiber;Nanosphere;Natural regeneration;novel;osteogenic;Outcome;Peptides;Periodontal Ligament;Periodontitis;permanent tooth;Persons;Population;Porosity;pre-clinical;Procedures;Property;Rattus;regenerative;Regenerative capacity;regenerative therapy;Shapes;stem cell differentiation;Surface;System;Technology;Testing;Therapeutic;Time;tissue regeneration;Tissues;Tooth Loss;Tooth root structure;Treatment outcome;Work

PROJECT_TITLE: MINE-MS for horizontal bone loss treatment

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: PS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: ALBANY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Narrative summary The scale-up of pre-exposure prophylaxis (PrEP) is one of the central strategies in the Ending the HIV Epidemic (EHE) initiative, which aims to reduce new HIV infections by 90% by 2030. Black women (BW) are disproportionately affected by HIV, having the highest incidence, prevalence, and deaths among women in the U.S; however, they are less likely to benefit from PrEP. The purpose of this study is to refine and test PrEP- WISE (Pre-exposure prophylaxis for Women In-charge of Sexual decision-making and Engagements), a novel, peer-led intervention designed to increase PrEP uptake among cisgender BW who live in New York State.

PI_NAMEs: WALCOTT, MELONIE  (contact)

PROJECT_TITLE: PS24-063, MARI: Refining and pilot testing an intervention to improve PrEP uptake among marginalized Black cisgender women PrEP-WISE

STUDY_SECTION_NAME: Special Emphasis Panel[ZPS1 SPE (60)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Walking in stroke survivors is compromised by muscle weakness, lack of joint coordination or increased tone which causes toe dragging, poor stability, and increased risk of falls. Limited ability to walk can affect veteran’s work, social activities, role as a family member, ability to help others, religious and recreational activities and health benefits derived from walking. A novel neuro-mechanical gait assist combining bracing with motorized knee joint with surface stimulation will be implemented to improve walking. The expected gains for the veteran are improved quality of life, participation and health benefits derived from walking.

PI_NAMEs: TRIOLO, RONALD J (contact)

PROJECT_TERMS: Abnormal coordination;Acceleration;Activities of Daily Living;Address;Affect;Aging;algorithm development;Algorithms;Ankle;Back;base;Clinical;Clinical Trials;clinically significant;Communities;Data;design;design and construction;Detection;detector;Development;Device Designs;Devices;dexterity;disabled;Energy consumption;Evaluation;Event;Exercise;exoskeleton;experience;Extensor;fall injury;fall risk;Family;Family member;feasibility testing;Feedback;Flexor;follow-up;foot;functional outcomes;Future;Gait;gait correction;Goals;Health Benefit;hemiparesis;Hemiplegia;Hip region structure;Home;Hybrids;improved;inclusion criteria;Individual;instrument;Intervention;Intuition;Isotonic Exercise;Joints;Knee;Knee joint;Laboratories;Limb structure;Manuals;Measures;meetings;Metabolic;Methodology;military veteran;Motor;Movement;Muscle;Muscle Weakness;neural stimulation;Neuromechanics;neuromuscular stimulation;novel;Orthotic Devices;Outcome;Outcome Measure;Outcome Study;Output;Pattern;Phase;pilot test;Population;Preparation;prevent;Professional Role;prototype;Quality of life;Recreation;rectus femoris;Religion;Research;Resistance;Role;Safety;Self-Help Devices;sensor;social;Societies;Specific qualifier value;Stroke;stroke survivor;Surface;synergism;System;Systems Development;Testing;Toes;Traumatic Brain Injury;Veterans;Walking;walking speed;Work

PROJECT_TITLE: Stimulation combined with externally powered motorized orthoses for stroke

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Chemotherapy medications can cause tinnitus, hearing loss, and communication deficits – known as ototoxicity – in up to half of Veterans receiving these drugs. Predicting which patients will experience ototoxicity is currently impossible. This is problematic because patients and their doctors generally lack awareness of early indicators of ototoxicity which could prompt intervention to address the subsequent health-related and psychosocial consequences. By examining the auditory injury and the burden of morbidity from ototoxic agents in relation to the perspectives of the patient-oncology team, the proposed research will provide a better understanding of which patients are at high risk for ototoxicity, why they are more susceptible to the damage, and how best to address their ototoxicity through monitoring, rehabilitation, and drug therapy interventions. To further enhance patient-centered oncologic care, this new knowledge will be used to develop tools for forecasting an individual patient's risk for ototoxicity using information obtained prior to treatment.

PI_NAMEs: KONRAD-MARTIN, DAWN L (contact)

PROJECT_TERMS: acoustic reflex;Address;Adult;Adverse effects;Aftercare;Age;Aging;Animal Model;Audiology;Auditory;Auditory Brainstem Responses;auditory pathway;aural rehabilitation;Behavioral;Bladder;Cancer Center;Cancer Survivor;Carboplatin;Caring;chemobrain;chemotherapy;Cisplatin;cisplatin induced hearing loss;Clinic;Clinical;Cochlea;Cognitive;Communication;Communication impairment;Comprehensive Cancer Center;cost effective;Counseling;Cueing for speech;Cues;Decision Making;Diagnosis;diagnostic tool;Disabling;Dose;drug modification;early awareness;Early Diagnosis;experience;follow-up;Functional disorder;Generations;Goals;Guidelines;Head and Neck Neoplasms;Health;Healthcare;Hearing;hearing impairment;Hearing problem;Hearing Tests;high risk;Human;Hyperacusis;improved;Incidence;Individual;individual patient;Injury;insight;Intervention;Knowledge;Labyrinth;Learning;Lesion;Letters;Life;Lung;Measurement;Measures;medical schools;Methods;Modeling;Monitor;Morbidity - disease rate;National Cancer Institute;neoplasm registry;Nerve Degeneration;neural;Neuronal Plasticity;Noise;novel diagnostics;novel strategies;Oncologist;Oncology;otoacoustic emission;ototoxicity;Outcome;Outer Hair Cells;Ovary;oxaliplatin;patient oriented;Patient risk;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Platinum;Policies;predictive modeling;Predisposition;prevent;processing speed;prospective;Provider;psychosocial;Publishing;Quality of life;Questionnaires;Recommendation;Reflex action;Rehabilitation therapy;Research;Resource Allocation;Risk;Risk Assessment;Sampling;Sensory;side effect;Site;Solid Neoplasm;sound;Speech;speech in noise;Speech Perception;standard of care;Stimulus;Surveys;survivorship;Symptoms;System;Testing;Testis;Therapeutic;Therapeutic Intervention;Time;Tinnitus;tool;Toxic effect;Universities;Veterans;Visit;Washington;Work

PROJECT_TITLE: Physiological, Behavioral and Predictive Correlates of Ototoxicity in Humans

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: This project is part of a 3-site VA BLR&D Collaborative Merit project that addresses the intersection between two significant challenges currently faced by the VA: 1) the increased rates of suicide among Veterans and, 2) the significant rates of individuals who have sustained mild traumatic brain injury (mTBI) while serving in Operation Enduring Freedom/Operation Iraqi Freedom. Veterans with mTBI die by suicide at 1.8 times the rate of the general Veteran population. We hypothesize that impulsivity may underlie this enhanced suicide risk and propose to investigate brain activity during impulsivity tasks in Veterans with and without a mTBI and suicide attempt history. These same cognitive (Delay discounting) and motor (Go/No-Go) impulsivity tasks will be conducted in animals (rats) at the VANJHCS site to facilitate a translational approach. Blood for biomarkers and genetic studies will be gathered at this JJPVA site, but analyses will be performed at the INDVA site. Identifying biomarkers for suicide risk in Veterans with mTBI is essential for developing targeted care.

PI_NAMEs: GOODMAN, MARIANNE  (contact);HAZLETT, ERIN A.

PROJECT_TERMS: Address;Amygdaloid structure;animal data;Animals;Anisotropy;Anterior;Award;Behavior;Behavior assessment;Behavioral;Biological Markers;biomarker identification;Blood;Brain;Caring;causal model;cingulate gyrus;Clinical assessments;Cognitive;comorbidity;Data;Death Rate;Decision Making;design;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;discounting;emotion regulation;Evaluation;Exhibits;Feeling suicidal;Female;Freedom;frontal lobe;frontal lobe function;Functional disorder;Functional Magnetic Resonance Imaging;Genetic study;genomic biomarker;Human;human data;human imaging;Impairment;Impulsive Behavior;Impulsivity;Individual;Inferior;Inflammation;Machine Learning;Magnetic Resonance Imaging;Major Depressive Disorder;male;Matched Group;Measures;mild traumatic brain injury;military veteran;Modeling;Motor;MRI Scans;multimodality;neural circuit;neural correlate;Neurobiology;neuroimaging;neuroinflammation;neuronal circuitry;Neurons;New Jersey;novel strategies;operation;Performance;Post-Traumatic Stress Disorders;predictive marker;Psychometrics;Rattus;Recording of previous events;Research;response;Risk;Risk Factors;Role;Serotonergic System;Site;Stress;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Temporal Lobe;trait;translational approach;Traumatic Brain Injury;Veterans;white matter

PROJECT_TITLE: CTBI: Traumatic brain injury-induced inflammation effects on cognitive evaluations and response inhibition: Mechanisms of increased risk forsuicidality


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Patient Safety;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: SHASQI, INC.

ORG_STATE: CA

PHR: Narrative Since most drugs are administered systemically, doses required to achieve effective therapeutic concentrations can cause toxicity and adverse drug events (ADEs) at sites of the body where they are not needed and leading to overall costs of ADE-related morbidity and mortality that are thought to exceed $177 billion. Shasqi’s Click Activated Protodrugs (CAP) platform uses a selective activating agent to capture a protodrug bioorthogonal click chemistry reaction and release active drug at a specific site in the body, thus enhancing its efficacy while minimizing systemic toxicity and ADEs. This project will develop a second-generation platform with an antigen- targeted version of the activating agent that would enable local activation of the protodrug at multiple sites and in locations that may not be reachable by injection.

PI_NAMEs: MCFARLAND, JESSE MISCHA;MEJIA ONETO, JOSE M (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acceleration;advanced system;Adverse drug event;Adverse Drug Experience Report;Anti-Inflammatory Agents;Antibiotics;Antibodies;Antibody-drug conjugates;Antigen Targeting;Antigens;Area;Attenuated;Autoimmune Diseases;Autoimmunity;Biology;Biopolymers;Breast Cancer Model;Cancer Model;Cell Line;Chemistry;Clinic;cohort;Conjugating Agent;cost;Cyclooctenes;Cysteine;design;Development;Disease;Dose;Dose Limiting;Doxorubicin;drug candidate;drug development;Drug Kinetics;Effectiveness;Engineering;ERBB2 gene;Failure;Future;Generations;Hospitalization;improved;in vivo;Infection;Injectable;Injections;Local Therapy;Location;Lysine;malignant stomach neoplasm;manufacture;Medical;Modality;Morbidity - disease rate;mortality;novel;Pain management;Pathologic;Patients;Pharmaceutical Preparations;Phase;Price;Quality of life;Reaction;Risk Reduction;Schedule;side effect;Site;Sodium Hyaluronate;Solid Neoplasm;Specificity;Sprague-Dawley Rats;Structure;success;System;systemic toxicity;Technology;Testing;Therapeutic;therapeutically effective;Time;Toxic effect;Toxicity Attenuation;Toxicology;tumor;Xenograft Model

PROJECT_TITLE: Antibody-guided localized activation of bioorthogonal protodrugs via click chemistry


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative Although diversity is a well-recognized driver of research innovation, biomedical research institutions have often failed to effectively incorporate minoritized groups. In partnership with the University of South Carolina’s leadership, this project will transform institutional policies, practices, and culture toward inclusive excellence with the aim of creating inclusive environmental change and in the process supporting a cohort of 10 tenure- track Assistant Professors. The results of this research will yield best practices and evidence-based models for institutional transformation toward inclusive excellence.

PI_NAMEs: FELDER, TISHA ;LIESE, ANGELA D (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Area;Biomedical Research;cohort;Collaborations;college;Communities;Complement;Development;Discipline of Nursing;Ensure;environmental change;Ethnic Origin;Evaluation;evidence base;experience;Faculty;Fostering;Funding;Future;Goals;health disparity;Health equity research;Health Sciences;improved;Incubators;innovation;Institution;Institutional Policy;Leadership;meetings;Minority Groups;Modeling;Nationalities;Process;professor;programs;Public Health Schools;Race;Recording of previous events;recruit;Research;response;Science;South Carolina;success;System;Teacher Professional Development;tenure track;Travel;United States National Institutes of Health;Universities

PROJECT_TITLE: Faculty Initiative for Improved Recruitment, Retention, and Experience (FIIRRE)


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative In this proposal we will utilize innovative molecular adjuvants to augment CD4 helper T cell responses with the primary objective of establishing sustained immunological memory against HIV.

PI_NAMEs: IYER, SWAMINATHAN SMITA (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: Adjuvant;Affinity;AIDS prevention;Animals;Antibodies;Antibody Affinity;Autologous;Avidity;B-Lymphocytes;Bioinformatics;Biology;Biometry;Blood;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Cellular Immunity;Cellular Immunology;Characteristics;Clinical;Collaborations;Data;design;DNA;DNA Vaccines;effectiveness measure;efficacy evaluation;env Gene Products;Generations;Glycoproteins;Goals;gp160;Helper-Inducer T-Lymphocyte;high dimensionality;HIV;HIV envelope protein;HIV vaccine;HIV-1;Humoral Immunities;Immune;Immunity;Immunization;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunologic Memory;Immunologics;improved;in vivo;Inflammatory Response;innovation;insight;Interferons;Interleukin-6;Laboratories;Longevity;Louisiana;lymph nodes;Macaca;Macaca mulatta;Memory;Messenger RNA;Modality;Modeling;Molecular;Molecular Profiling;Monitor;mucosal site;Mucous Membrane;neutralizing antibody;Nucleic Acids;peripheral blood;Persons;Phenotype;Plasma Cells;prevent;Proliferating;protective efficacy;Proteins;Publishing;rectal mucosa;Rectum;Regimen;Reporting;response;RNA vaccine;Serology;simian human immunodeficiency virus;Structure of germinal center of lymph node;T cell response;Testing;Time;Tissues;tool;Universities;vaccine adverse event;Vaccine Design;vaccine development;vaccine efficacy;vaccine platform;Vaccines;vector;Viral;Virus

PROJECT_TITLE: Harnessing CD4 T follicular helper 1 cells for HIV vaccine efficacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (02)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: RELEVANCE Recent studies reported increasing numbers of Plasmodium vivax infections in Duffy- negative individuals and that the parasites may have adapted to the African populations, but the erythrocyte invasion mechanisms are unknown. This study will investigate the expression and function of specific erythrocyte binding genes in Duffy-negative P. vivax and the immune response of Duffy-negative individuals to P. vivax infections in Ethiopia, where malaria is a major public health problem and about 30% of the 1.2 million confirmed malaria cases are P. vivax. Knowledge of P. vivax invasion mechanisms and host immune responses in Duffy negatives will have important implications for P. vivax vaccine development and vivax malaria risk assessment both within and outside Africa.

PI_NAMEs: LO, EUGENIA  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;African;African ancestry;Age;Antibodies;Antibody Response;antigen binding;Antigens;Binding;Binding Proteins;Biochemical;Biological Assay;Candidate Disease Gene;candidate identification;Case Study;Cells;Classification;comparative;Copy Number Polymorphism;Data;density;Diagnosis;differential expression;Disease;DNA biosynthesis;Enrollment;Epidemic;Erythrocytes;Ethiopia;feasibility research;Flow Cytometry;Foundations;Gender;Gene Dosage;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genomic signature;Genotype;Health;Immune response;Immunize;Immunoassay;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;inhibiting antibody;Invaded;Knowledge;Ligand Binding;Ligands;Logistics;Malaria;Measures;Molecular;Mutation;Oryctolagus cuniculus;Outcome;parasite invasion;Parasites;Patients;Phenotype;Plasma;Plasmids;Plasmodium vivax;Plasmodium vivax vaccine;Population;Process;Proteins;Public Health;receptor;Recombinant Proteins;Reporting;Research;residence;Reticulocytes;Risk Assessment;RNA;sample collection;Sampling;Site;Surface;Time;transcriptome;transcriptome sequencing;Transfection;vaccine development;Variant;vector;Vivax Malaria;Whole Blood

PROJECT_TITLE: Plasmodium vivax Erythrocyte Invasion Mechanisms and Humoral Immune Response in Duffy Negative Africans

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The training of the next generation of knowledge creators in digestive diseases will require concerted efforts to harness the explosion of information that has been created by advances in genomics, functional genomics, network analysis, stem cell biology, the human microbiome, and other technologies. Now more than ever, a planned approach to the research career development of physician scientists – one that must incorporate solid scientific environment, mentorship, didactic curriculum, monitoring, and inter action – becomes critical to maximize likelihood of success. To preserve a training environment that, despite a challenging funding environment, has continued an exceptional track record of producing leaders in academic gastroenterology, we have retained preceptors from a stellar group of fundamental, translational and clinical scientists who have adapted and incorporated these recent advances while also having actively participated in mentoring.

PI_NAMEs: CHUNG, RAYMOND T (contact);GOESSLING, WOLFRAM

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Digestive System Disorders;Research Training

PROJECT_TITLE: Research Training in Digestive Diseases


PHR: PROJECT NARRATIVE The Training Program in Endocrinology at Massachusetts General Hospital (MGH)’s goal is to train MD, and MD-PhD physician scientists and PhD scientists in clinical and/or laboratory research related to endocrinology, diabetes, metabolism and allied fields. The public health burden of endocrine diseases (such as diabetes and its complications, obesity and osteoporosis) and its associated societal costs are enormous, and therefore there is an urgent need to train and enable the best and brightest individuals considering careers in biomedical investigation to deploy contemporary experimental methods that will generate insights into this set of disorders, elucidate their pathophysiology, and illuminate potential avenues for treatment. With these goals in mind, the MGH Training Program in Endocrinology has produced a large number of endocrine investigators over the years, many of whom have become authentic leaders in science, academia and industry.

PI_NAMEs: MILLER, KAREN K (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Training Programs

PROJECT_TITLE: Training Program in Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Research training is integral to the future of biomedical advancement and the needs of academic centers to provide an environment that integrates the vision of research to deepen our understanding of biology, stimulate interdisciplinary research teams, and reshape clinical research that in turn accelerates medical discovery and improves health. The present proposal will train medical doctors (MDs) and scientists (PhDs) to study the origins of disorders of glucose metabolism in children (illnesses such as obesity, pre-diabetes, diabetes) using basic or clinical science investigation and applying these to accelerate medical discoveries to improve children's health, prevent development and/or ameliorate severity of metabolic diseases. This approach will undoubtedly improve the health of the US population.

PI_NAMEs: OLSON, DAVID P;PADMANABHAN, VASANTHA ;VAZQUEZ, DELIA M (contact)

PROJECT_TERMS: Development;Metabolic Diseases

PROJECT_TITLE: Developmental Origins of Metabolic Disorders


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE. Latinx are at increased risk for Alzheimer's disease and related dementias (ADRD) compared with non- Hispanic whites. Bilingualism may reduce ADRD risk but prior studies lack detailed characterization of within- group differences among bilinguals such as age of second language (L2) acquisition, L2 proficiency, and frequency of dual language use and its relationship to cognition in the presence of neuropathology. The current study will elucidate mechanisms underlying the relationship among bilingualism, neuroimaging markers of pathology, and cognitive function, which has the potential to inform novel interventions to preserve cognitive function and reduce ADRD disparities.

PI_NAMEs: ARCE, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Attention;bilingualism;Biological Markers;Brain;Buffers;California;career;cerebral atrophy;Cerebrovascular Disorders;Clinical;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive neuroscience;cognitive reserve;cognitive testing;cohort;Communities;comparison control;Cross-Sectional Studies;Data;Data Analyses;data harmonization;dementia risk;Disparity;disparity reduction;Education;Enrollment;Environmental Risk Factor;Exclusion;executive function;experience;Family;Foundations;Frequencies;Goals;health disparity;Healthcare Systems;Height;Hispanic Populations;Home;human old age (65+);imaging biomarker;Immigrant;Immigration;Impaired cognition;Intervention;Knowledge;Language;Latinx;Latinx population;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Methodology;Methods;middle age;Modeling;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;Neuropsychology;Not Hispanic or Latino;novel;offspring;Outcome;Pathology;Phase;Population;Population Heterogeneity;Populations at Risk;Positron-Emission Tomography;preservation;protective effect;protective factors;Proxy;Psycholinguistics;recruit;Reporting;Research;Research Personnel;resilience;resilience factor;Risk;Role;sex;Sex Differences;social culture;sociocultural determinant;Socioeconomic Status;Statistical Methods;Symptoms;tau Proteins;Training;Universities;Washington

PROJECT_TITLE: Factors of Resilience to Alzheimers Disease and Related Dementias among Latinx: The Role of Bilingualism

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The purpose of this application is to better understand heart failure among people with human immunodeficiency virus (HIV). People with HIV have much higher risks for heart failure than the general population for reasons that are not adequately understood. Our goal in this application is to fundamentally improve how heart failure is understood in HIV, with the ultimate goal of improving heart failure prevention and treatment in HIV.

PI_NAMEs: FEINSTEIN, MATTHEW JOEL (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: abacavir;Address;adjudication;aging population;American Heart Association;Anti-Retroviral Agents;antiretroviral therapy;Autopsy;Biological Markers;Biological Specimen Banks;Biology;candidate marker;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;case control;CD4 Lymphocyte Count;CD8B1 gene;Cells;Clinical;clinical care;Clinical Data;clinical imaging;clinical risk;clinically relevant;cohort;comorbidity;Complex;Data;design;Diabetes Mellitus;Diagnosis;EFRAC;Endothelium;Epidemiology;Event;Female;Fibroblasts;Freezing;Functional disorder;Funding;Gene Expression;General Population;Genes;Goals;Heart failure;Heart Rate;hemodynamics;High Prevalence;high risk;Hispanic;HIV;Hypertension;Immune;Immune response;Immune System Diseases;Immunologics;immunoregulation;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;Intervention;Investigation;kidney dysfunction;Knowledge;Link;Longevity;male;Maps;Methods;middle age;migration;Modernization;monocyte;mortality;Multicenter Studies;multidisciplinary;Myocardial;Myocardial tissue;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;novel;Obesity;overexpression;Pathogenesis;Patient Outcomes Assessments;Patients;Pattern;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;power analysis;Predisposition;preservation;Prevention;protein biomarkers;Proteins;Proteomics;Protocols documentation;Recovery;Regulation;Regulatory T-Lymphocyte;Request for Proposals;Research;Research Priority;Resolution;response;Risk;Risk Factors;RNA;Role;Sampling;screening;senescence;Specimen;Structural defect;Syndrome;T-Cell Activation;T-Lymphocyte;targeted treatment;Therapeutic Intervention;Time;Tissues;trafficking;transgender;United States;Update;Validation;Weight Gain;Writing

PROJECT_TITLE: Immunologic, Inflammatory, and Clinical contributors to HIV-Related Heart Failure with Preserved Ejection Fraction (HFpEF)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Depression, non-suicidal self-injury (NSSI) and suicidal thoughts and behaviors (STB) commonly emerge in youth and each represent important risk factors for death by suicide. The current proposal seeks to delineate the neurodevelopmental trajectories of strength and flexibility in fronto-limbic, cortico-striatal and default mode networks associated with the risk, onset and early course of depression, NSSI and STB in children and adolescents in the ABCD study using novel analytic strategies. New insights from this study will provide the foundation for designing personalized interventions to facilitate early detection of depression and suicide risk, and to guide interventions capable of restoring healthy brain development and averting serious negative outcomes including suicide.

PI_NAMEs: CULLEN, KATHRYN REGAN (contact);FIECAS, MARK JOSEPH BARILAR

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Age;age acceleration;aging related;Anisotropy;Biological;biological systems;Brain;Brain imaging;Child;Childhood;Clinical;cognitive development;cohort;Conflict (Psychology);Corpus striatum structure;Data;Data Collection;design;Development;Early Diagnosis;Early Intervention;early life adversity;Entropy;Environmental Risk Factor;ethnic minority;Exhibits;experience;Exposure to;Feeling;Feeling suicidal;flexibility;follow-up;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Gender Identity;gender minority youth;genetic risk factor;Home;Hormonal;Hormones;imaging modality;improved;Individual;Individual Differences;Information Theory;insight;Intervention;Laboratories;Link;longitudinal design;Measures;Mental Depression;Methods;minority stress;Modeling;neural;neural network;neuroimaging;neuromechanism;non-suicidal self injury;novel;novel strategies;Outcome;parent project;Parents;Pattern;personalized intervention;Population Study;Psychopathology;pubertal timing;Puberty;racial minority;Recording of previous events;Reporting;Research;response;Rest;Rewards;Risk;Risk Factors;Sampling;Schools;Self-Injurious Behavior;Sexual and Gender Minorities;sexual identity;sexual minority youth;Shapes;Signal Transduction;Stress;stressor;Structure;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Techniques;Theoretical model;Thick;Thinking;Time;white matter;Work;Workplace;Youth

PROJECT_TITLE: Developmental Trajectories of Brain Network Strength and Flexibility: Relationship to Risk, Onset and Course of Depression and Self-Harm in Youth

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Hypertension;Infectious Diseases;Prevention;Primary Health Care

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This hybrid clinical-implementation study will be conducted in 3 phases: 1) a pre-implementation phase using CFIR to determine the barriers and facilitators of the adoption of TASSH and to develop the practice facilitation (PF) intervention; 2) an implementation phase which will compare, in a cluster RCT of 30 HIV clinics among 960 HIV+ patients, the effect of the PF intervention vs. a self-directed condition (i.e. receipt of information for implementation of HTN control without PF) on BP reduction; and 3) a post-implementation phase using RE- AIM to compare the effect of PF vs. self-directed condition on adoption and sustainability of TASSH. The PF intervention will comprise an advisory board of key stakeholders who will provide leadership support for TASSH adaptation and its implementation; practice facilitators, and trained nurses, who will deliver TASSH.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET ;OGEDEGBE, OLUGBENGA G. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;Adopted;Adoption;Africa;antiretroviral therapy;blood pressure reduction;burden of illness;Caring;Characteristics;Chronic Care;Climate;Clinic;Clinical;Clinical effectiveness;Collaborations;Consolidated Framework for Implementation Research;Counseling;Country;Data;design;Effectiveness;effectiveness/implementation design;evidence base;Evidence based intervention;experience;Feedback;General Population;Ghana;Health;Health Insurance;Healthcare;Healthcare Systems;HIV;Hybrids;Hypertension;hypertension control;implementation framework;implementation process;implementation strategy;implementation study;Income;Infrastructure;Insurance Coverage;Intervention;Knowledge;knowledge base;Leadership;Life Style;low and middle-income countries;Maintenance;Mediator;Medical Research;Modeling;Morbidity - disease rate;mortality;New York;Nigeria;Nigerian;Nurses;Patients;Performance;personalized approach;Persons;Pharmaceutical Preparations;Phase;Physicians;post implementation;pragmatic implementation;Prevalence;prevent;primary care practice;Primary Health Care;primary outcome;Probability;Protocols documentation;Qualitative Methods;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;research to practice;Risk;Risk Assessment;Role;routine care;routine practice;secondary outcome;Self Direction;System;system-level barriers;Testing;Titrations;Training;Translating;Universities;uptake

PROJECT_TITLE: Integration of Hypertension Management into HIV Care in Nigeria: A Task Strengthening Strategy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-G(91)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Substance Misuse

ORG_CITY: Boston

ORG_NAME: PASCALL SYSTEMS, INCORPORATED

PHR: PROJECT NARRATIVE Effective nociception monitoring and control during surgery can minimize post-operative pain and reduce post- operative opioid requirements among surgical patients, thereby decreasing their chances of opioid dependency, but existing nociception monitoring tools are imperfect in that they monitor markers such as heart rate and blood pressure that are inherently influenced by various intraoperative factors. This leads to suboptimal opioid administration for nociception control. This project proposes to develop a novel surgical nociception monitor that comprises of an integrated measure of nociceptive control based on neurophysiological (EEG) and autonomic (EDA) markers of arousal and nociception that aren’t susceptible to intraoperative factors.

PI_NAMEs: LE MAU, TUAN  (contact);PURDON, PATRICK L.

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Algorithms;Anesthetics;Anti-Hypertensive Agents;Arousal;Blood Pressure;Chronic;Data;Dose;Electroencephalography;General Anesthesia;Heart Rate;Hemorrhage;improved;Incidence;Light;Measures;Methods;Monitor;neurophysiology;new technology;Nociception;novel;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid epidemic;Patients;Postoperative Pain;Postoperative Period;Predisposition;prospective;sensor;Surgeon;tool

PROJECT_TITLE: Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia to minimize postoperative opioid requirements


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Our Program plans to focus on a vital unmet need in idiopathic pulmonary fibrosis (IPF), understanding the etiologic and initial pathogenic events in lung fibrosis so we can prevent the development of progressive and irreversible pulmonary fibrosis. We will accomplish this through 3 highly interactive Scientific Projects, 3 Research Cores, and an Administrative Core and by focusing on the initial pathogenic mechanisms, dominant risk factors, and a two-hit model of disease pathogenesis. In aggregate, we will identify key mechanisms that are critical to initiation of the fibroproliferative process that may serve as new targets for drug development, especially in early stages of disease.

PI_NAMEs: SCHWARTZ, DAVID ALBERT (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Aging;airway epithelium;alveolar epithelium;Apoptosis;Apoptosis Promoter;Biological;biological adaptation to stress;Bleomycin;Bronchioles;Cells;Cyst;Development;Disease;disease model;disorder prevention;Distal;Dominant Genetic Conditions;drug development;Early Intervention;endoplasmic reticulum stress;Enhancers;Epigenetic Process;epigenetic regulation;Epithelial Cells;epithelial injury;Epithelium;Etiology;Event;Exposure to;Fibroblasts;Fibrosis;Functional disorder;gain of function;genetic variant;Goals;Heat shock proteins;idiopathic pulmonary fibrosis;In Vitro;Individual;Inflammation;Injury;injury and repair;Intervention;Lung;lung injury;Microscopic;Modeling;Molecular;MUC5B gene;Mus;new therapeutic target;non-genetic;novel;overexpression;Pathogenesis;Pathogenicity;Pathologic;Patients;Phenotype;Physiological;post-COVID-19;Predisposition;prevent;preventive intervention;Process;programs;promoter;Public Health;Pulmonary Fibrosis;recruit;Reporting;Research;respiratory;response;Risk;Risk Factors;Role;Scanning;Stress;Structure of parenchyma of lung;Tobacco smoke;Usual Interstitial Pneumonia;Variant

PROJECT_TITLE: Diversity Supplement to Mechanisms Regulating Lung Injury and Early Lung Fibrosis

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: ACEPRE, LLC

PHR: PROJECT NARRATIVE Public Health Relevance: Alzheimer’s disease is the sixth-leading cause of death in the United States and costs about $345 billion in 2023. This research will develop an AD brain targeted delivery system that can carry N- acetylcysteine into the brain to effectively quench the elevated ROS, attenuate the activation of microglia, reduce Aβ burden, eliminate senescent cells, improve the survival of neurons in the brain, and stop the progression of Alzheimer’s disease. The success of validating this concept will open a new era for treating Alzheimer’s disease, which is consistent with the mission of the NIH.

PI_NAMEs: FAN, DAPING ;XU, PEISHENG  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3xTg-AD mouse;abeta deposition;Acetylcysteine;Aducanumab;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amino Acids;Amyloid beta-Protein;Animal Model;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Antioxidants;Area Under Curve;Attenuated;behavior test;Behavioral;behavioral impairment;Binding;Biochemical;Biological Availability;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cause of Death;Cells;Cholinesterase Inhibitors;Clinical Trials;cost;Cyclic GMP;Cysteine;Data;Deposition;Development;Disease Progression;disulfide bond;donepezil;Dose;drug development;Drug Kinetics;effective therapy;Effectiveness;Ensure;feasibility testing;Formulation;Galantamine;Glutathione;glutathione receptor;Half-Life;Health;Healthcare;healthcare community;Human;Hydrophobicity;improved;In Vitro;Inflammatory Response;Injections;intravenous administration;Investigational New Drug Application;Lead;Learning;Ligand Binding;Macrophage;Maintenance;manufacture;Maximum Tolerated Dose;Measures;Memantine;Memory;Microglia;Mission;Monoclonal Antibodies;mouse model;Mus;Muscarinic Acetylcholine Receptor;Names;nanoparticle;Neurofibrillary Tangles;neuronal survival;Nicotinic Receptors;NMDA receptor antagonist;novel strategies;Oral;oxidation;Oxidative Stress;Pathologic;Penetration;Performance;Pharmaceutical Preparations;Phase;phase 2 study;Plasma;Play;Polymers;Process;Production;Property;public health relevance;Publishing;Reporting;Research;research and development;rivastigmine;Role;Safety;safety testing;senescent cell;Senile Plaques;Serum Albumin;side effect;Small Business Technology Transfer Research;success;Sulfhydryl Compounds;Surveys;Symptoms;System;systemic toxicity;targeted delivery;tau Proteins;Technology;Therapeutic;therapeutic evaluation;therapeutic target;tool;Toxic effect;treatment effect;Treatment Efficacy;treatment strategy;Treatment-related toxicity;United States;United States National Institutes of Health;β-amyloid burden

PROJECT_TITLE: Develop a novel strategy to deliver N-acetylcysteine for AD treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Immunization;Infectious Diseases;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE  Herpes simplex virus (HSV) causes cold sores, genital sores, ocular infections, and encephalitis; can cause permanent ocular and brain damage and death in newborns; and is associated with neurodegeneration. This work will test the ability of maternal immunization and vector-delivered antibodies to protect newborns and adults from HSV-induced corneal diseases, behavioral pathologies, and neurodegeneration in a mouse model. We will also test the role of the autophagy pathway in the genesis of HSV-induced corneal disease, and whether autophagy- modulating agents can prevent or reduce ocular damage and other sequelae of HSV infection.

PI_NAMEs: LEIB, DAVID A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;acute infection;Acyclovir;adaptive immunity;adeno-associated viral vector;Adult;Alzheimer's Disease;American;Animal Model;Anterior;Anti-viral Agents;Antibodies;Anxiety;Area;Autophagocytosis;Bacteremia;Behavior;Behavioral;Birth;Blepharitis;Blindness;Brain Death;Brain Injuries;Central Nervous System Diseases;Clinical;Clinical Research;clinically significant;Communities;Congenital herpes simplex;congenital infection;Conjunctivitis;Cornea;Corneal Diseases;Data;Dependovirus;Development;Diagnosis;Disease;Economic Burden;Emotional;Encephalitis;Epithelium;Exposure to;Eye diseases;Eye Infections;Female;fetal;Frequencies;Funding;Gene Expression;Genes;genital infection;Genitalia;Goals;Health;Herpes Labialis;Herpes Simplex Infections;Herpes stromal keratitis;Herpesviridae;Herpesvirus 1;Herpetic Keratitis;Human;Human Herpesvirus 2;Human Milk;human model;Immune;Immunize;improved;Incidence;Individual;Infant;Infection;Integration Host Factors;Intervention;Keratitis;latent infection;Learning;Life Cycle Stages;long-term sequelae;Maternal antibody;maternal vaccination;Maternally-Acquired Immunity;Mediating;member;Memory;Morbidity - disease rate;mortality;Mothers;mouse model;Mouth Diseases;mucosal site;Mus;Natural Immunity;Neonatal;neonatal health;neonatal immune system;neonatal infection;Neonatal Mortality;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurodevelopmental Disability;Neurologic;Neurons;neurosensory;neurotropic;Newborn Infant;novel;novel therapeutic intervention;offspring;Outcome;Pathogenesis;Pathology;Pathway interactions;Pattern;Peripheral;Phase;Placenta;Population;postnatal;postnatal period;preclinical study;prevent;Prevention;Prevention approach;prophylactic;prototype;Recrudescences;Recurrence;Reporting;Research;Resistance;Risk;Role;Seizures;Sepsis;Seroprevalences;Simplexvirus;Site;Skin;skin disorder;Spastic Tetraplegia;standard of care;Strategic Planning;Testing;Therapeutic;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Tissues;translational study;vaccine candidate;Vaccines;vector;Vertical Transmission;Viral;Viral Encephalitis;Viral Genes;Viral Load result;Viral Pathogenesis;viral transmission;Virus;Virus Diseases;Virus Latency;Virus Replication;Vision;Vision Tests;Visual System;Vulnerable Populations;Work

PROJECT_TITLE: Viral and Host Factors in Herpetic Diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Mental Health;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative. In older adults with musculoskeletal pain, both joint pathology and pain have been associated with mobility decline, but the relationship between joint pathology and pain and their unique contributions to mobility decline is more complex, because pain is shaped by a combination of central and peripheral factors. The proposed study goes beyond the characterization of an individual mechanism and integrates multiple fields of study using a biopsychosocial approach to identify the factors that contribute to functional trajectories of mobility decline in aging.

PI_NAMEs: COOMBES, STEPHEN ;CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Accounting;Address;Affective;Age;age related;aged;Aging;Anxiety;Behavioral;biopsychosocial;Body mass index;Brain;chronic musculoskeletal pain;Clinical;Communities;Complex;Corticospinal Tracts;Data;density;Diffusion Magnetic Resonance Imaging;disability impact;Disinhibition;Elderly;Electroencephalography;Ethnic Origin;experience;field study;Frequencies;Gait speed;Individual;Joints;Knowledge;life span;Link;Longitudinal Studies;Measures;Mediating;Mental Depression;Mobility decline;Mobility disability;Musculoskeletal Pain;neural;Neurobiology;neuroimaging;novel;older adult;Older Population;Pain;Pain Measurement;Pathology;Patient Self-Report;Peripheral;Pharmaceutical Preparations;Positioning Attribute;Predictive Factor;preservation;Process;prospective;Prospective Studies;psychosocial;Publishing;Quality of life;Race;recruit;Research;Research Design;Role;sex;Shapes;Site;social;Socioeconomic Factors;standardize measure;Structure;Testing;Time;Tissues;Visit;Walking;Water;Work

PROJECT_TITLE: Biopsychosocial pain predictors of mobility decline in aging


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project narrative (as submitted for R00): Pontocerebellar hypoplasia (PCH), a severe neurological disorder for which there is no cure that is caused by mutations in several RNA processing complexes. The aims of this proposal will determine how several PCH- linked complexes assemble, recognize and process RNA, how they are enzymatically and spatially regulated, and how PCH mutations disrupt their function. This work is to better understand how these complexes function normally in healthy states and how their dysfunction leads to PCH.

PI_NAMEs: HAYNE, CASSANDRA K (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Cell Death;Cell Physiology;Cessation of life;Complex;Development;endonuclease;Engineering;Enzymes;Functional disorder;Genetic;insight;Introns;Lead;Link;link protein;Molecular;Molecular Biology;Mutation;Nervous System Disorder;nuclease;Pontocerebellar hypoplasia;prenatal;Process;protein complex;protein protein interaction;Proteins;Proteomics;Regulation;RNA;RNA Processing;RNA Splicing;Role;Transfer RNA;Work;Yeasts

PROJECT_TITLE: Structural and Functional Characterization of Pontocerebellar Hypoplasia Associated Nucleases


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE This career transition award supports research to better understand the function of the visual system. This research investigates the way that visual information in different parts of the brain is combined to guide perception and behavior.

PI_NAMEs: TURNER, MAXWELL HOLTE (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;3D virtual reality;Advisory Committees;Animal Behavior;Animals;Award;Behavior;behavior measurement;Behavioral;Behavioral Paradigm;behavioral study;Brain;Brain imaging;career;career development;Career Transition Award;Complex;Computer Models;Cues;dimension reduction;Drosophila genus;fly;Functional Imaging;gene therapy;Genetic;genetic manipulation;Goals;Human;Laboratories;large datasets;Lateral;Link;Measures;Mediating;Mentors;Methods;Mission;Modeling;Modernization;Motion;National Eye Institute;neural;neural circuit;Neurons;Neurosciences;neurotransmission;olfactory bulb glomeruli;Optic Lobe;Optics;parallel processing;Partner in relationship;Pathway interactions;Perception;Phase;Population;Property;Research;Research Support;Resources;response;Rest;Shapes;Signal Transduction;Smell Perception;Statistical Models;Stimulus;Structure;Techniques;Testing;theories;Time;tool;Training;Universities;Vision;Visual;visual information;visual neuroscience;Visual Pathways;Visual Perception;visual stimulus;Visual System;Walking;Work

PROJECT_TITLE: Representation and integration of diverse visual features in circuits and behavior


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: NARRATIVE Ubiquitin-like modifications (UBLs) are rapid, reversible and can profoundly alter cell fate and function. Intriguingly, the majority of UBLs are involved in the cellular response to stress, in particular the response to infection, ER-stress and autophagy. This proposal takes an interdisciplinary approach combining cutting-edge proteomics with biochemistry and cell biology to determine fundamental properties and modes of action of understudied UBLs to address the fundamental question of how the cell responds to stress by decoding novel networks of covalent protein complexes.

PI_NAMEs: RADOSHEVICH, LILLIANA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Animals;Autoimmune Diseases;Autophagocytosis;Biochemistry;biological adaptation to stress;Catabolic Process;Cell Membrane Permeability;Cells;Cellular biology;Cellular Stress;cellular targeting;Coupled;Disease;endoplasmic reticulum stress;FRAP1 gene;gene repression;Genetic;in vivo;Infection;interdisciplinary approach;ISG15 gene;Laboratories;Malignant Neoplasms;Metabolic;Metabolism;Methods;Modification;Neurodegenerative Disorders;novel;Outer Mitochondrial Membrane;Pathway interactions;Physiological;Property;protein complex;Proteins;Proteomics;response;Role;Stress;Ubiquitin;Ubiquitin Like Proteins;Work

PROJECT_TITLE: Discovery of Novel Mechanisms of Action of Ubiquitin-Like Proteins in Cellular Stress Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Adolescent Wellness Visits in Tanzania: Bundling evidence-based prevention services to increase uptake of  HIV Testing and Counseling and other health services Adolescents are less likely to access prevention-oriented health services such as HIV testing and counseling (HTC) and contraception than adults, yet young people bear a disproportion burden of poor HIV and reproductive health outcomes in many low-resource settings. This study evaluates a new service delivery platform for reaching adolescents in Tanzania with HTC and other evidence-based screening services via clinic-based ‘Adolescent Wellness Visits’ coordinated between primary schools and health facilities that offer a package of youth-friendly services. We posit that by coupling sexual and reproductive health (SRH) services with non- SRH services such as nutrition, vision, dental and mental health screenings, applicable for all adolescents, adolescent health service use including HTC will increase and a tone will be set for a ‘culture of health and wellness’ during this critical developmental period.

PI_NAMEs: BAUMGARTNER, JOY NOEL (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: acceptability and feasibility;Adherence;Adolescence;Adolescent;Adolescent Health Services;Adult;Age;Ally;Area;behavioral health;behavioral outcome;Bundling;Caring;Clinic;Clinic Visits;Clinical;Consent;Consolidated Framework for Implementation Research;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost-effectiveness evaluation;Counseling;Coupling;critical developmental period;cultural health;design;Dissemination and Implementation;Education;Eligibility Determination;evidence base;Evidence based intervention;Evidence based practice;Focus Groups;Friends;Future;Health;Health care facility;Health education;health seeking behavior;health service use;Health Services;Health Services Accessibility;Health system;high risk sexual behavior;HIV;Human immunodeficiency virus test;implementation research;implementation trial;improved;Individual;informant;Intervention;Interview;Letters;low and middle-income countries;Mental Health;Modeling;National Institute of Child Health and Human Development;neglect;nutrition;Oral health;Outcome;Persons;pilot test;Policies;pragmatic implementation;Prevention;prevention service;Preventive Health Services;Preventive service;primary outcome;Primary Schools;Provider;Puberty;Public Health;Randomized, Controlled Trials;Reproductive Health;Reproductive Health Services;Research;Resource-limited setting;response;Risk;Risk Assessment;Role;Schools;Science;screening;screening services;secondary outcome;service delivery;Services;sexual and reproductive health;sexually active;sexually active adolescent;Sexually Transmitted Diseases;Shoulder;Site;Structure;Students;Tanzania;Testing;Training;unintended pregnancy;Universities;uptake;Vision;Visit;Well Child Visits;wellness visit;Youth

PROJECT_TITLE: Adolescent Wellness Visits in Tanzania


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: The proposed research is relevant to Veterans because it will provide timely and important information that supports the VA Strategic Goals to provide care that emphasizes Veteran well-being and independence and reduce risk of suicide. Depression in nursing homes is a serious problem that can lead to increased morbidity, mortality, care burden, and cost of care. In Community Living Centers (CLCs; VA nursing homes) the prevalence of depression is nearly 40%. Depression is a major risk factor for suicide. Veterans discharged from CLCs have a substantially higher risk of suicide compared to other VA users of similar age and gender. Treatments for depression using behavioral activation are rarely used in CLCs. This study will provide information on how best to implement an evidence-based behavioral intervention for depression in CLCs that will reduce symptoms of depression and improve Veteran well-being. The results will be immediately and directly relevant to staff and residents of CLCs and will be designed to be useful throughout the VA.

PI_NAMEs: MILLS, WHITNEY L (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adoption;Affect;Age;Behavior Therapy;Behavioral;Bite;care burden;care costs;Caring;Clinical;Collaborations;Communication;Communities;community intervention;community living;Competence;Complex;Data;Dedications;depressive symptoms;design;Disease;Dissemination and Implementation;Documentation;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness/implementation study;evidence base;Evidence based intervention;Feeling suicidal;follow-up;foster home;Fostering;functional improvement;Gender;Goals;High Prevalence;high risk;Home;Hybrids;implementation fidelity;implementation framework;implementation measures;implementation strategy;improved;information gathering;innovation;integrated care;Intervention;Language;Long-Term Care;Maintenance;male;Manuals;Measures;Medical;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;Morbidity - disease rate;mortality;Nursing Homes;nursing intervention;Outcome;Performance;Personal Satisfaction;Persons;Population;post implementation;Preparation;Prevalence;Primary Care;Process;programs;Provider;psychosocial;Public Health;Quality of Care;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recreation;reduce symptoms;Research;Research Personnel;Risk Factors;Risk Reduction;Sampling;satisfaction;severe mental illness;Site;Spottings;Standardization;Substance abuse problem;success;suicidal;suicidal risk;Suicide;Suicide prevention;Support System;System;Teleconferences;Telephone Interviews;Testing;tool;Training;uptake;Veterans;Visit;webinar;Work

PROJECT_TITLE: Implementing the Behavioral Activities Intervention (BE-ACTIV) to Reduce Depression among Veterans in Community Living Centers

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: The TBI literature provides preliminary evidence supporting associations between TBI exposures and poor health and functional outcomes, and extant longitudinal cohort studies of service members and Veterans with military combat and training exposures offer researchers access to extant data addressing factors that modify risks for developing and/or recovering from a range of brain disorders, including TBI, PTSD, pain, depression, and suicidality. Pooling individual participant level data from longitudinal TBI research studies will result in a large enough dataset to consider relevant moderators, mediators, and confounders in analyses and allow for more impactful and clinically meaningful findings. We have developed a model data harmonization system to combine data from multiple heterogenous studies and facilitate the analysis of a single pooled dataset. The research team will develop a 2-year plan to define a standardized approach and create a crosswalk for the modalities and domains of LIMBIC and TRACTS longitudinal cohort to create a unified assessment profile that can be analyzed.

PI_NAMEs: O'NEIL, MAYA ELIN (contact)

PROJECT_TERMS: Address;Algorithms;associated symptom;Biological Markers;Brain Diseases;brain health;Brain Injuries;Categories;Center for Translational Science Activities;Clinical;cohort;Collaborations;combat;comorbidity;Data;Data Analyses;data harmonization;data modeling;Data Pooling;data resource;data reuse;Data Set;Disparate;Elements;Ensure;experience;FAIR principles;follow-up;functional outcomes;Funding;Health;health knowledge;Image;Individual;Knowledge;large scale data;Leadership;Liquid substance;Literature;Longitudinal cohort;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Measurement;Measures;Mediator;Mental Depression;Mental disorders;Metadata;method development;Methods;Military Personnel;Modality;multimodal data;multimodality;Names;Natural Language Processing;Pain;Participant;Pattern;physical symptom;Physiological;pilot test;Post-Traumatic Stress Disorders;Prognostic Factor;programs;prospective;Recovery;Reproducibility;Research;Research Personnel;research study;Resources;Risk;Risk Factors;service member;Site;Source;Standardization;stress disorder;success;suicidal;Symptom Burden;System;Techniques;Training;Veterans;Walking;Work

PROJECT_TITLE: Harmonizing Veteran Longitudinal Cohorts to Identify Prognostic Factors in Post-Traumatic Brain Health

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ORG_CITY: DURHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Metal–protein interactions are essential for the function of at least one-third to one-half of all proteins in cells. The incorrect binding of a metal to a protein, however, can lead to harmful effects on the cell, including toxicity. The research proposed here is designed to identify the protein targets of metal stress and elucidate molecular mechanisms that lead to toxicity. The outcomes will advance our understanding of how proteins across the proteome respond to exposure to excess levels of biologically relevant Zn and Cu, with important implications for developing pharmacological agents to leverage metal stress against microbial pathogens and cancer.

PI_NAMEs: FITZGERALD, MICHAEL C;FRANZ, KATHERINE J. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;anti-cancer;antimicrobial;Binding;Biological;Biological Assay;biophysical properties;Biophysics;cancer cell;Cancer cell line;Candida albicans;Cell Line;Cell Physiology;Cell Separation;Cell Survival;cell type;Cells;Chemicals;cofactor;Collaborations;Copper;Data;design;Development;Environment;Escherichia coli;Escherichia coli Proteins;Event;experience;Exposure to;Foundations;Functional disorder;Global Change;Goals;Growth;Homeostasis;Human;Immune system;In Vitro;Ionophores;Ions;Laboratories;Link;Location;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolism;Metal exposure;Metalloproteins;Metals;Methodological Studies;Methods;microbial;Molecular;Monitor;Neurodegenerative Disorders;Nutrient;Nutritional Requirements;Organism;Outcome;Outcome Study;pathogen;pathogenic microbe;Pathway interactions;pharmacologic;Physiologic pulse;Precipitation;Predisposition;prostate cancer cell;protein folding;protein function;protein misfolding;Proteins;Proteolysis;Proteome;Proteomics;Proxy;Publishing;Research;Signal Transduction;Stress;Techniques;Testing;Therapeutic;Time;tool;Toxic effect;Trace Elements;trafficking;Translations;Work

PROJECT_TITLE: Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic Methods


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE The focus of this research is on the sleep related function of a brain network that is affected by Tau and amyloid beta deposition in Alzheimer’s disease and the relationship between these functional changes and impaired memory in Alzheimer’s disease. This research is relevant to public health because it will increase knowledge about the role of changes in the functional interactions between the cortex and hippocampus and use current technologies to perform a functional dissection of Tau and amyloid beta clearance in these critical brain circuits, including a noninvasive approach for clearing tau and amyloid beta. The proposal is relevant to NIH’s mission in that it will expand the knowledge base, and establish a new research platform for understanding the mechanism of impaired memory in Alzheimer’s disease.

PI_NAMEs: WILBER, AARON A (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Affect;Alzheimer's Disease;Amyloid beta-Protein;Animal Model;Brain;brain abnormalities;brain dysfunction;Cells;Communication;Coupling;Disease;Disease Progression;Dissection;efficacy testing;Exhibits;familial Alzheimer disease;Functional disorder;Funding;Genes;glymphatic clearance;Grant;Hippocampus;Human;hypocretin;Impaired cognition;Impairment;improvement on sleep;Individual;insight;Instruction;Knowledge;knowledge base;Learning;Limbic System;Memory;memory acquisition;Memory impairment;Mission;mouse model;Neurofibrillary Tangles;novel;optogenetics;Pathologic;Pathway interactions;Patients;Pattern;Photic Stimulation;Public Health;Rat Transgene;Research;Rodent;Rodent Model;Role;Sleep;Sleep Disorders;Societies;spatial memory;Symptoms;Synapses;System;tau aggregation;tau Proteins;Technology;Transgenic Mice;United States National Institutes of Health;way finding

PROJECT_TITLE: Targeting the orexin pathway to treat sleep disorders and improve glymphatic clearance in Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: We have a spectrum of effective substance use prevention to harm reduction interventions that can improve outcomes and save lives, but the vast majority of rural communities lack access. This study builds on our team’s long history of community-partnered work building/testing a continuum of effective prevention and harm reduction interventions and leading pragmatic and sustainable programs training health professionals to deliver substance- related care. The overall goal of this project is to apply a user-centered design approach with rural community partners to co-develop a novel hub and spoke model/intervention specifically to help rural clinics adopt multiple prevention and harm reduction services, and test in a stepped wedge effectiveness-implementation trial.

PI_NAMEs: LIN, LEWEI ALLISON (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: addiction;Address;Adopted;Adoption;Ambulatory Care Facilities;Area;behavioral health;care delivery;Caring;Clinic;Clinical;Communities;community partners;community-centered;cost effective;Data;design;Development;disparity reduction;E-learning;Education;effective intervention;effectiveness testing;effectiveness/implementation trial;Elements;Face;Fentanyl;fentanyl test;Future;future implementation;Goals;Harm Reduction;health disparity;Health Professional;Health Services Accessibility;health training;Healthcare Systems;high risk;implementation facilitators;improved;improved outcome;innovation;Intervention;intervention effect;intervention refinement;Interview;Knowledge;Learning;Lived experience;Manuals;marginalized population;Mediator;medical specialties;Mental Health;Michigan;Modeling;multi-component intervention;Naloxone;novel;Opioid;opioid misuse;opioid use;opioid use disorder;Outpatients;Overdose;overdose education;overdose risk;Patient-Focused Outcomes;Patients;Persons;Phase;Policies;Prevention;preventive intervention;Primary Care;primary outcome;Process;Program Sustainability;programs;Public Health;Readiness;Recording of previous events;Research;response;Risk Reduction;Rural;rural area;Rural Community;rural disparities;rural health clinic;Rural Population;rural residence;Services;Site;social stigma;socioeconomics;Specific qualifier value;Sterility;Stimulant;Subgroup;substance use;substance use prevention;System;teleconsultation;telehealth;test strip;Testing;Training;Training Programs;usability;user centered design;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Coalition for harm reduction and prevention (CHRP): Developing and testing a novel Hub and Spoke Model to implement prevention and harm reduction in rural clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-E (A1)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Osteoporosis;Physical Injury - Accidents and Adverse Effects

PHR: Project Narrative Osteoporosis of the spine is a common cause of undetected fracture in the aging population. This research will yield a computationally efficient protocol for modeling degradation of vertebral trabeculae to assess aging-related changes in fracture risk from a clinical population. If successful, this research will impact healthcare of millions of adults suffering from osteoporosis.

PI_NAMEs: MOORE, AUSTIN MARK (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Adult;Affect;age effect;age related;age related changes;Age Years;Aging;aging population;aging process;aging related;American;Biological;biomechanical model;Biomechanics;bone;Bone Density;bone health;bone quality;Bone remodeling;bone strength;Cadaver;career;Clinical;clinical application;clinical imaging;clinically relevant;Compression Fracture;Computer Models;Computing Methodologies;cortical bone;cost;Data;density;Development;Diagnosis;Elasticity;Elderly;Elements;erection;Facet joint structure;Failure;follow-up;Fracture;fracture risk;Funding;Geometry;Geriatrics;Goals;Healthcare;Height;Human body;human model;Image;Image Analysis;imaging Segmentation;improved;Individual;Injury;insight;interdisciplinary approach;Lateral;Laws;Link;lumbar vertebra bone structure;Lumbar Vertebral Fracture;Measurement;Measures;Mechanics;men;Methods;Modeling;Morphology;Musculoskeletal;network models;novel;older adult;Orthopedics;Osteoporosis;Osteoporotic;Patients;Physicians;Population;Posture;process optimization;Property;Protocols documentation;Radiology Specialty;Research;Resolution;response;Risk;Risk Assessment;Safety;Sampling;Scanning;Scientist;Series;Severity of illness;simulation;skeletal;skills;Solid;Specimen;Spinal Fractures;Spinal Injuries;spine bone structure;Stress;Structure;substantia spongiosa;System;Techniques;Testing;Thick;Time;United States;United States National Aeronautics and Space Administration;United States National Institutes of Health;Validation;Variant;vertebra body;Vertebral column;Weight;Woman;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Development and Validation of an Image Based, Computed Trabecular Network Model for Estimating Vertebral Fracture Risk in the Aging Population


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

PHR: PROJECT NARRATIVE Arsenic is an environmental carcinogen the effects 200 million people worldwide. Yet, the underlying cause of arsenic mediated carcinogenesis remains without a molecular explanation. These studies will explore the relationship between redox and protein homeostasis and how this can lead to arsenic-derived tumors.

PI_NAMEs: CHAPMAN, ELI  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Agar;Air;Antioxidants;Arsenic;ATP Hydrolysis;ATP phosphohydrolase;Autophagosome;Binding;biological adaptation to stress;Cancer Model;carcinogenesis;Carcinogenicity Tests;Carcinogens;Cell Line;Cells;Cellular Stress;Chronic;Classification;Clinical;Clinical Trials;Complex;contaminated water;CRISPR/Cas technology;CUL3 gene;Cytoprotection;Data;Developing Countries;disabled;Dose;Ensure;Environment;Environmental Carcinogens;Epithelial Cells;Event;Exposure to;Feedback;Genes;Genetic Transcription;Growth;Health;Homeostasis;Human;In Vitro;in vivo;Infection;inhibitor;Isogenic transplantation;Laboratories;Letters;Lung;Lung Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;metaplastic cell transformation;Modeling;Molecular;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;Mutagenesis;Mutate;Mutation;novel;Nude Mice;Oxidation-Reduction;Oxidative Stress;Persons;Play;pre-clinical;prevent;Procedures;promoter;Proteins;proteostasis;proteotoxicity;RBX1 gene;Reporting;response;Response Elements;Risk;Role;segregation;Skin Cancer;Soil;Stress;subcutaneous;Testing;Therapeutic;Transformed Cell Line;tumor;Tumor Tissue;Tumorigenicity;ubiquitin-protein ligase;Up-Regulation;Xenograft Model

PROJECT_TITLE: Redox and Protein Homeostasis in Arsenic Tumorigenicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-L(06)]