NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

PHR: Narrative The Immunogenomics Core will be responsible for accurate and reproducible monitoring of immune and genomic changes in peripheral blood and tumor microenvironment in patients with ovarian cancer. The Immunogenomics Core will leverage the expertise of Center for Immunotherapy and Shared Resources at Roswell Park. Centralization and standardization of the performance of the immunologic and genomic assays will facilitate head-to-head comparisons of the immune/genomic signatures and changes being induced by cutting-edge immunotherapies in the Roswell Park Ovarian Cancer SPORE. The Immunogenomics Core personnel will work closely with Individual Research Project Leaders and Core Directors for accomplishing the projects and discovering novel findings through the immunologic and genomic data.

PI_NAMEs: MATSUZAKI, JUNKO  (contact)

PROJECT_TERMS: Ablation;antigen detection;Ascites;assay development;Bioinformatics;Biological Assay;Biometry;Blood specimen;Cancer Center Support Grant;career;Cell Culture Techniques;Cell Separation;Cells;Clinical Research Protocols;Clinical Trials;Collaborations;Computers and Advanced Instrumentation;Confusion;cost;Cryopreservation;cytokine;Cytometry;Data;data acquisition;Data Analyses;data exchange;Databases;design;Development;Dimensions;DNA methylation profiling;Education;Ensure;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Equipment;exome sequencing;Flow Cytometry;Genetic;genomic data;genomic signature;Genomics;Genomics Shared Resource;Genus Hippocampus;Goals;head-to-head comparison;Human Resources;Image;Immune;immune function;Immune response;Immunoassay;immunogenic;Immunogenomics;Immunologic Monitoring;Immunologics;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;Individual;Infrastructure;instrumentation;interest;Label;Laboratories;Malignant neoplasm of ovary;Management Information Systems;Measures;Metabolic;Methodology;Monitor;Morphology;multidimensional data;multiplexed imaging;Mutation;neoantigens;neoplasm immunotherapy;next generation sequencing;novel;organizational structure;Outcome Measure;Pathology;Pathway Analysis;Patient Participation;Patients;Peptide Vaccines;Peptides;Performance;peripheral blood;Peripheral Blood Mononuclear Cell;Procedures;Program Research Project Grants;programs;Qualifying;Quality Control;Reagent;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA analysis;Role;Running;Sampling;Slide;Specific qualifier value;Specimen;Stains;Standardization;Statistical Data Interpretation;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Technology;technology/technique;Testing;Time;Tissues;transcriptome;transcriptome sequencing;tumor;Tumor Antigens;tumor microenvironment;Vaccines;Validation;Work

PROJECT_TITLE: Immunogenomics Core


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Robust computational methods can be used to greatly reduce the time and funds in environmental health research and help environmental scientists and toxicologists to prioritize the future directions of research. This novel matrix completion algorithm called Coupled Matrix/Tensor-Matrix Completion (CM/TMC) and Coupled Matrix/Tensor-Tensor Completion (CM/TTC) has great potential in discovering molecular targets and target tissues of environmental exposures. The outcome of the proposed study will assist in filling the data gap between the novel chemicals produced annually and the toxicity assessment.

PI_NAMEs: WANG, KAI  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Algorithms;Award;Benchmarking;Bioconductor;Biological;career;career development;Chemicals;Chemistry;Communities;comparative;Computing Methodologies;Coupled;dashboard;Data;data integration;data portal;Data Science;Data Set;Databases;Disease;Dose;Drug Design;Drug Targeting;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Science;Exposure to;Funding;Future;gene environment interaction;gene expression database;Genomics;Genotype-Tissue Expression Project;Goals;Health;Human;Human Cell Line;improved;in silico;In Vitro;in vivo;large datasets;Machine Learning;Mentors;Mentorship;Methods;Michigan;Molecular;Molecular Target;Names;nonbinary;novel;Outcome;Performance;performance tests;Persons;Phase;Play;Poison;Policies;Production;public health research;Quantitative Structure-Activity Relationship;Reproducibility;Research;research and development;Research Personnel;Resources;response;Role;safety assessment;Scientist;Standardization;Targeted Toxins;Testing;Time;Tissue-Specific Gene Expression;Tissues;Toxic effect;Toxicity Tests;Toxicogenomics;Toxicology;Toxin;Training;Universities;Validation;Visualization;web portal

PROJECT_TITLE: Improving chemical exposome target prediction by application of Coupled Matrix/Tensor-Matrix/Tensor Completion algorithms


ADMINISTERING_IC: EY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Coloboma, a developmental defect in eye structure characterized by a hole or cleft in the eye, is a condition estimated to occur in ~1:10,000 live births, and a significant cause of blindness worldwide. It results from disrupted development of a specific structure in the eye called the choroid (or optic) fissure; however, despite its importance, we have a poor understanding of the crucial initial step of choroid fissure formation at the cellular or molecular level. Here, we aim to determine the mechanisms governing choroid fissure formation and its regulation by signaling pathways, tissue-tissue interactions, and metabolism, using the small freshwater teleost fish Danio rerio (zebrafish), and a combination of live microscopy, computational methods, and molecular genetics.

PI_NAMEs: KWAN, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Agrin;Anosmia;Automobile Driving;Basal Cell Nevus Syndrome;Biological;Blindness;Candidate Disease Gene;cell motility;Cell Nucleus;Cell Shape;Cells;Cellular Morphology;CHARGE syndrome;Choroid;Coloboma;Computing Methodologies;Coupling;Custom;Cytoskeleton;Data;Defect;Development;Dimensions;Disease;Dystroglycan;Embryo;Erinaceidae;Event;experimental study;Extracellular Matrix;Eye;Focal Adhesions;Four-dimensional;Fresh Water;Funding;gene regulatory network;Genes;Genetic Transcription;Human;Image;Image Analysis;imaging modality;In Vitro;in vitro activity;in vivo;Individual;innovation;Live Birth;Mechanics;Metabolic;Metabolism;Methods;Microscopy;Mitochondria;Modeling;Molecular;molecular dynamics;Molecular Genetics;Morphogenesis;mutant;novel;optic cup;Optics;Organ;Pathologic;Patients;Phenotype;Positioning Attribute;Process;Proliferating;Proteoglycan;PTCH gene;quantitative imaging;Regulation;Resources;retinal axon;Role;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;software development;Structure;syndecan-4;Syndrome;System;teleost fish;Testing;therapeutic target;Time;Tissues;Up-Regulation;Visual impairment;Visualization;Zebrafish;zebrafish development

PROJECT_TITLE: Hedgehog Signaling in Optic Fissure Morphogenesis and Coloboma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative: Clostridium difficile infections (CDI) have been categorized as one of the top 5 “urgent” public health threats by CDC. Host factors including genetics and immune mediators are key regulators of CDI pathogenesis. Here, we propose to investigate how a common mutation in the gene for leptin receptor affects CDI-induced inflammatory cytokine Macrophage Inhibitory Factor.

PI_NAMEs: MADAN, RAJAT  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;adverse outcome;Affect;Antibodies;Apoptosis;Arginine;Automobile Driving;Autophagocytosis;Bacteria;BCL2 gene;Biological;Biological Response Modifiers;Blood;Breeding;Calibration;Categories;Cells;Chemotactic Factors;Chemotaxis;Clinical;Clostridium difficile;Colon;comparison control;Confocal Microscopy;cytokine;Data;design;Development;Disease;Disease Outcome;DNA Sequence Alteration;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Exhibits;experimental study;Exposure to;Flow Cytometry;Genes;Genetic;Glutamine;Grant;Hematopoietic;Human;Image;Immune;Immune response;Immunoglobulin G;Immunohistochemistry;Immunologic Factors;improved;In Vitro;in vivo;induced pluripotent stem cell;Induction of Apoptosis;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibition of autophagy;insight;Integration Host Factors;Interleukin-8B Receptor;intestinal epithelium;Intestines;Label;Leptin;leptin receptor;life span;LoxP-flanked allele;Macrophage;Migration Assay;Migration Inhibitory Factor;Modeling;mortality;Mus;mutant;Mutation;neutrophil;Neutrophilia;new therapeutic target;Nosocomial Infections;novel;Organoids;Outcome;pathogen;Pathogenesis;Pathology;Pathway interactions;Peptide Signal Sequences;pharmacologic;Plasma;Production;Proteins;Pseudomembranous Colitis;Public Health;Publishing;receptor;reconstitution;Regulation;release factor;Reporter;Reporting;Risk;Role;Severities;Severity of illness;Shapes;Single Nucleotide Polymorphism;Source;Stains;Testing;tissue injury;Tissues;Toxin;trafficking;Western Blotting

PROJECT_TITLE: Regulation of C. difficile colitis by host genetic and immune factors

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PI_NAMEs: PALOP, JORGE J (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's Disease Pathway;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Behavior;Behavior assessment;Behavioral;Brain;Candidate Disease Gene;cell type;Cells;circadian;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;Collaborations;Complex;Dependence;Disease;Disease Progression;Electroencephalography;Electrophysiology (science);Etiology;familial Alzheimer disease;Functional disorder;Gene Expression;Genotype;Histopathology;Human;Human Amyloid Precursor Protein;Impairment;in vivo;Interneurons;Knock-in Mouse;Machine Learning;MAPT gene;Microglia;Molecular;morris water maze;mouse model;Mus;Mutation;network dysfunction;neural network;Neurons;novel;optogenetics;overexpression;Parvalbumins;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Physiological;Physiology;Protein Isoforms;Proteins;resilience;single-cell RNA sequencing;Somatostatin;tau Proteins;Testing;Therapeutic;transcriptome;transcriptomics;Transgenes;wireless

PROJECT_TITLE: Project 2: Co-pathogenic Interactions between ApoE Isoforms and Abeta in Neural Network Dysfunction of Alzheimer's Disease


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE The overall objective of this project is to reprogram the ovarian tumor microenvironment (TME) with an “armed” oncolytic vaccinia virus for local delivery of a CXCR4 antagonist (OVV-CXCR4-A-Fc) to minimize the potential for high rates of systemic toxicities. We will determine whether intraperitoneal OVV-CXCR4-A-Fc is safe and triggers a transformation of the TME from tolerogenic to immunogenic in a first-in-human clinical trial focused on patients with platinum resistant/refractory EOC. We plan to integrate immunologic and proteogenomic profiles to provide an exhaustive characterization of the interface between the TME and the immune system in order to examine the molecular mechanisms that generate functionally distinct effector/memory T cells against shared antigens, neoantigens and how vascular checkpoints regulate tumor-specific T cell trafficking into the ovarian TME.

PI_NAMEs: ODUNSI, KUNLE  (contact)

PROJECT_TERMS: Address;antagonist;anti-tumor immune response;antigen-specific T cells;Antigens;Bioinformatics;Biometry;Blood Vessels;cancer cell;cancer initiation;Cancer Model;Cancer Patient;CD44 gene;CD8B1 gene;cell motility;Cells;checkpoint receptors;Chemoresistance;chemotherapy;Clinical;clinical efficacy;clinical translation;Clinical Trials;Combination immunotherapy;combinatorial;Cross Presentation;CXCR4 gene;Cyclic GMP;Cytolysis;Data;Dendritic Cells;Doxorubicin;Drug resistance;endothelial stem cell;Engineering;Epithelial ovarian cancer;exhaustion;Exhibits;Extravasation;first-in-human;Frequencies;Functional disorder;Funding;Goals;Histopathology;Immune;immune checkpoint;Immune checkpoint inhibitor;immune resistance;Immune system;immunogenic;immunogenic cell death;immunogenicity;Immunologics;Immunosuppression;Immunotherapy;improved;in vivo;Infiltration;innovation;intraperitoneal;intravital microscopy;Ligands;Liposomal Doxorubicin;lymphocyte trafficking;Malignant neoplasm of ovary;Mediating;Mediator;Melanoma;Memory;Molecular;Mus;Mutation;Myeloid-derived suppressor cells;neoantigens;Non-Small-Cell Lung Carcinoma;oncolytic vaccinia virus;Oncolytic viruses;ovarian neoplasm;Pathogenesis;Pathway interactions;Patients;PD-1/PD-L1;PD-L1 blockade;Phase I/II Clinical Trial;Phase I/II Trial;Platinum;Population;Pre-Clinical Model;Production;programmed cell death ligand 1;programmed cell death protein 1;programs;proteogenomics;Proto-Oncogene Protein c-kit;recruit;Refractory;Regimen;Regulatory T-Lymphocyte;Relapse;Reporting;Research Personnel;Resistance;resistance mechanism;Serous;standard of care;stemness;Stromal Cell-Derived Factor 1;success;synergism;systemic toxicity;T cell response;T cell therapy;T memory cell;T-Lymphocyte;Testing;Toxic effect;trafficking;translatable strategy;translational impact;tumor;Tumor Antigens;Tumor Expansion;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Up-Regulation;Variant;Vascular Endothelial Growth Factors;Vascular Endothelium;Viral Vector;Visualization

PROJECT_TITLE: Project 1


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Stable maintenance of telomeres is critical to preserve genomic integrity, and studies have found that defects in protein complexes that ensure telomere maintenance, could lead to various human diseases including cancer. The overall goal of this project is to provide detailed knowledge of the mechanisms that allow conserved shelterin and CST complexes to ensure stable maintenance of telomeres by controlling DNA replication at telomeres and attenuating DNA damage responses. Since proteins involved in telomere maintenance and DNA damage responses are very well conserved between fission yeast and humans, we expect our findings to help guide future studies of telomere regulation mechanisms in humans.

PI_NAMEs: NAKAMURA, TORU  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;age-related disease;Aging;Aplastic Anemia;Applications Grants;Binding;Biochemical;Biological Assay;Bypass;Cell Proliferation;Cells;Chromosomes;Coats plus syndrome;Collaborations;Complex;Cytology;Data;Defect;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA polymerase A;DNA Polymerase I;DNA Polymerase II;DNA Repair;DNA-Directed DNA Polymerase;Dyskeratosis Congenita;effective therapy;Ensure;Eukaryotic Cell;experimental study;Fission Yeast;flexibility;Functional disorder;Future;Genes;Genetic;Genetic Recombination;Genome;genome integrity;Genomic Instability;Goals;Growth;Health;Human;human disease;idiopathic pulmonary fibrosis;Inherited;insight;interest;Knowledge;Label;Laboratories;Length;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Modeling;mRNA Cleavage and Polyadenylation Factors;Mutation;Nature;neoplastic cell;novel;Nucleoproteins;Organism;Pattern;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Polymerase;preservation;prevent;protein complex;Proteins;Proteomics;recruit;Regulation;Research Project Grants;response;RNA;RNA-Directed DNA Polymerase;Role;Site;Structure;Sumoylation Pathway;Telomerase;telomere;telomere damage;telomere loss;Telomere Maintenance;Tissues;transcription termination;treatment strategy;tumor;tumor growth

PROJECT_TITLE: Regulation of Telomere Maintenance in Fission Yeast

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Synovial sarcoma (SS) is an aggressive malignancy driven by the SS18-SSX oncofusion that is refractory to chemotherapy leading to a high mortality rate. Here, we identify a remarkable therapeutic vulnerability to both genetic and pharmaceutical disruption of the SUMOylation pathway, including with the in-clinic SUMOylation inhibitor TAK-981, that is dependent on SS18-SSX. We provide data the mechanistic basis is through deSUMOylation-mediated re-distribution of BAF complexes leading to DNA damage, cell death, and frank tumor regressions in mouse models of SS.

PI_NAMEs: FABER, ANTHONY CHARLES (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: addiction;Age;Antineoplastic Agents;Automobile Driving;Biochemical;Biology;Categories;Cell Culture Techniques;Cell Death;Cell Line;chemotherapy;Child;Chromatin Remodeling Factor;Clinic;Clinical;Clinical Trials;clinically actionable;Code;combat;Combination Drug Therapy;Complex;Data;Databases;Death Rate;Deposition;Development;Diagnosis;Disease;DNA Damage;efficacy testing;Employment;Event;expectation;experimental study;Funding;Gene Fusion;Genes;Genetic;Grant;Immunotherapy;in vivo;inhibitor;innovation;insight;kinase inhibitor;knock-down;Light;Malignant Neoplasms;Mediating;member;Modeling;mouse model;Mus;Mutation;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Pharmacologic Substance;Phosphotransferases;Post-Translational Protein Processing;pre-clinical;preclinical study;Prognosis;Proteins;Proteome;Proteomics;Recurrence;Refractory;Research Design;Research Personnel;restoration;Role;Safety;Sarcoma;Series;Small Interfering RNA;SMARCE1 gene;Soft tissue sarcoma;standard of care;stem;success;Sumoylation Pathway;Survival Rate;synovial sarcoma;Systemic Therapy;targeted treatment;Teenagers;Testing;Therapeutic;Toxic effect;transcriptome;Translating;Translations;tumor;tumor growth;whole genome;young adult

PROJECT_TITLE: SUMOylation disruption is toxic for SS18-SSX-driven synovial sarcoma

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: MUCKE, LENNART  (contact)

PROJECT_TERMS: abeta accumulation;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acid Substitution;Amyloid beta-Protein;Amyloid deposition;Antisense Oligonucleotides;Apolipoprotein E;apolipoprotein E-4;Apolipoproteins;Behavioral;Brain;Brain Diseases;Cell Nucleus;cell type;Cells;Clinical;Cognitive deficits;Collaborations;Dementia;Disabling;Disease;early onset;Etiology;Experimental Models;experimental study;familial Alzheimer disease;Frontotemporal Lobar Degenerations;Gene Expression;gene product;Genes;genetic risk factor;Gliosis;Heterozygote;Human;Impaired cognition;insight;Intervention;Knock-in;Mediating;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Nerve Degeneration;network dysfunction;neural;neural network;Neuronal Dysfunction;Neurons;novel;Onset of illness;overexpression;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pattern;Phenotype;Physiological;prevent;Protein Isoforms;Risk;Role;Senile Plaques;Synapses;tau mutation;tau Proteins;Therapeutic;transcriptomics;Variant;Wild Type Mouse

PROJECT_TITLE: Project 3: Roles of Tau Levels, Sequence and Interactors in Neural Network Dysfunction of Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: CORCES, MICHAEL RYAN (contact)

PROJECT_TERMS: Acceleration;Acute;Adverse effects;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Antisense Oligonucleotides;apolipoprotein E-4;Apolipoproteins;ATAC-seq;Behavior assessment;Brain;brain cell;Brain region;Cell Communication;Cell Nucleus;cell type;Cells;cellular targeting;Clinical;Cognition;Cognitive;cognitive testing;cohort;Collaborations;combinatorial;comorbidity;Complex;Data;data integration;design;Disease;Dissection;effective therapy;epigenomic profiling;epigenomics;epileptiform;Etiology;Functional disorder;Gene Expression;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;Genotype;Goals;Hippocampus;Human;humanized mouse;Impaired cognition;Inherited;Interneurons;Investigation;Lead;Link;Modeling;Molecular;Molecular Target;mouse model;multiple omics;Mus;Nerve Degeneration;network dysfunction;neural network;Neurofibrillary Tangles;Neuroglia;Neurons;neurotransmission;novel;novel therapeutic intervention;novel therapeutics;optogenetics;Parietal Lobe;Pathogenesis;Pathologic;Pathology;Phenotype;Prevention;Prevention strategy;Process;Proteins;Research;response;Sampling;Senile Plaques;Severities;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;tau Proteins;Techniques;Therapeutic;Therapeutic Effect;Therapeutic Intervention;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;Translations

PROJECT_TITLE: Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omics


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Relevance The Developmental Research Program of an NCI SPORE is the incubator of the cutting-edge, potentially paradigm-shifting research that will be tested to become the next generation standard-of-care. The Roswell Park Ovarian Cancer SPORE will provide two complementary advantages as a mechanism for supporting translational research: 1) a constructive review process provided by the Executive Committee, which facilitates evolution of hypotheses, and 2) a rapid review and award procedure which allows immediate and flexible funding of new ideas.

PI_NAMEs: MOYSICH, KIRSTEN B. (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Application procedure;Area;Award;base;Basic Science;Cancer Research Project;career;Clinical;clinical application;Clinical Sciences;Collaborations;Critiques;Data;Development;Diagnosis;Disabled Persons;Environment;Epidemiologist;Etiology;Evolution;Extramural Activities;Faculty;Financial Support;flexibility;Foundations;Funding;Funding Agency;Future;Goals;Grant;high reward;high risk;Human;improved;Incubated;Incubators;Individual;Infrastructure;innovation;Institution;interest;International;Malignant neoplasm of ovary;Measures;next generation;Pathogenesis;patient population;Patients;Peer Review Grants;Pilot Projects;Population;Population Research;Population Sciences;Prevention;Principal Investigator;Procedures;Process;Program Research Project Grants;programs;Recommendation;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Running;Scientist;Source;Specimen;standard of care;Study Section;success;Supplementation;Testing;Therapeutic;translational cancer research;translational potential;Translational Research;translational research program;Underrepresented Minority;University of Pittsburgh Cancer Institute;Vertebral column;Woman;Work

PROJECT_TITLE: Developmental Research Program


ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE Fungal infections have dramatically increased during the last decade and new treatment options are needed. This proposal focuses on the characterization of new fungal vaccines and new antifungal compounds, providing new insights into the development of better therapeutic strategies.

PI_NAMEs: DEL POETA, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;anti-fungal agents;Antigens;Aspergillosis;Aspergillus fumigatus;Biochemical;Biological Assay;Blood Circulation;blood glucose regulation;Brain;capsule;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Characteristics;Cryptococcosis;Cryptococcus neoformans;Data;Defect;Development;Disease;Dose Limiting;Environment;Funding;Fungal Antigens;Fungal Vaccines;fungus;Genes;Glucose;glucosidase;Glucuronic Acids;Glycolipids;Goals;Growth;high throughput screening;HIV;Immune response;Immunity;Immunocompromised Host;immunodeficiency;improved;In Vitro;in vitro activity;in vivo;Incubated;Infection;inhibitor;insight;Intranasal Administration;Knowledge;Libraries;Life;Lipids;Lung;Lymphopenia;Mannose;Mediating;Meningoencephalitis;microorganism;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mycoses;novel;novel therapeutic intervention;Pathogenesis;pathogenic fungus;Pathogenicity;Patients;Phenotype;Polysaccharides;Predisposition;prevent;Primary Infection;Public Health;Role;screening;secondary infection;side effect;small molecule;sterol glucoside;Sterols;Structure;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Vaccines;Virulence;Virulent;Xylose

PROJECT_TITLE: Lipid-mediated fungal pathogenesis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Chronic alcohol consumption leads to hepatocellular injury, fat accumulation, and liver inflammation and sometimes leads to liver cirrhosis or hepatocellular carcinoma. We have found that changes in phosphorylation status of UBC9, an essential enzyme required for SUMOylation (post-translational modification), is associated with altered inflammatory response and liver function. Our proposal aims to investigate how phospho UBC9 modifications in liver macrophages can be controlled and may provide a therapeutic target for alcoholic associated liver disease.

PI_NAMEs: TOMASI, MARIA LAUDA (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Affinity;Alcohol abuse;Alcohol consumption;alcohol exposure;Alcoholic Liver Diseases;Alcohols;Binding;Biological;Biological Process;Cells;Chemotactic Factors;chronic alcohol ingestion;Circulation;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Conditioned Culture Media;crosslink;CYP2E1 gene;cytokine;cytotoxic;Data;design;Development;disease model;DNA Repair;Endosomes;Endotoxins;Enzymes;Ethanol;Event;extracellular vesicles;Family member;Fatty acid glycerol esters;Genes;Genetic Transcription;Health;Hepatic;hepatocellular injury;Hepatocyte;I Kappa B-Alpha;Impairment;Induced Hepatocytes;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-1 beta;Interleukin-6;Interleukins;Intracellular Transport;Kupffer Cells;lipid biosynthesis;Lipopolysaccharides;Liver;Liver Cirrhosis;Liver diseases;liver function;liver inflammation;liver injury;Macrophage;Maps;Mass Spectrum Analysis;Mediating;microsomal ethanol-oxidizing system;Microsomes;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;neutrophil;NF-kappa B;novel;novel therapeutic intervention;Nuclear;p65;Pathway interactions;Phosphopeptides;Phosphorylation;Play;Post-Translational Protein Processing;posttranscriptional;prevent;Primary carcinoma of the liver cells;problem drinker;Process;Production;Proteins;Proteomics;rab GTP-Binding Proteins;Reactive Oxygen Species;Regulation;Role;Serine;Signal Pathway;Signal Transduction;Site;Source;SRC gene;src-Family Kinases;Sumoylation Pathway;Testing;therapeutic target;Tissues;TLR4 gene;TNF gene;TNFRSF5 gene;trafficking;Triglycerides;Tumor Necrosis Factor Receptor;Tyrosine;Ubiquitin;Ubiquitin-Conjugating Enzymes

PROJECT_TITLE: Role of phospho UBC9 in alcohol-associated liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Patient Safety;Pediatric;Prevention

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PUBLIC NARRATIVE Acute pancreatitis is an acute inflammatory process resulting in damage to pancreatic parenchyma with an annual incidence ranging from 5 to 45 cases per 100,000 persons. Recent studies indicate that   30-40% of patients develop diabetes mellitus or impaired glucose tolerance within three to four years of  even a single episode of acute pancreatitis   the autoantibodies associated with Type 1 diabetes (T1D) are found in people with a history of  pancreatitis, indicating that pancreatitis-related diabetes poses long-term burden and significant risk of  comorbidities as frequently as in other patients with diabetes The Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) will investigate the incidence, etiology, and pathophysiology of diabetes following acute pancreatitis with an emphasis on the auto-immune processes that result in T1D as well as the incidence, time course, and relationship to pancreatitis severity, the roles of pancreatitis etiology, genetic and genomic risk factors, environmental and biological factors, and potential biomarkers for the development of T1D.

PI_NAMEs: CHINCHILLI, VERNON M (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Accountability;Acute;acute pancreatitis;Adherence;Adverse event;Agreement;Ancillary Study;Area;Autoantibodies;Autoimmune Process;biobank;Biological;Biological Factors;Biological Markers;biomarker development;Clinical;clinical center;Clinical Trials;cohort;Collaborations;Collection;college;Common Data Element;comorbidity;Conflict of Interest;Contracts;cost;Data;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data management;Data Management Resources;Data Set;data standards;data submission;Development;Devices;Diabetes Mellitus;Disease Progression;Documentation;drug distribution;early detection biomarkers;Electronic Health Record;Endocrinology;Enrollment;Ensure;Environmental Risk Factor;Ethnic Origin;Etiology;expectation;experience;Friends;Functional disorder;Funding;Gastroenterology;Genetic;genetic risk factor;Genomics;Geography;Grant;Health;Health Insurance Portability and Accountability Act;Health Sciences;Immune;impaired glucose tolerance;Incidence;Inflammatory;Information Dissemination;Infrastructure;insight;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Internet;Laboratories;Longitudinal, observational study;Manuscripts;Medical;Medicine;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Pancreas;Pancreatitis;Parents;participant enrollment;Patients;Pennsylvania;Persons;Population Heterogeneity;potential biomarker;Predisposition;Preparation;Procedures;Process;programs;prospective;Protocols documentation;Public Health;Publications;Qualifying;quality assurance;Quality Control;Randomized;Recording of previous events;recruit;Reporting;Research Design;Research Personnel;research study;response;Risk;Risk Factors;Role;Safety;Safety Management;Sample Size;Sampling;Security;Services;Severities;Site Visit;Statistical Data Interpretation;Subgroup;Support System;System;Testing;Therapeutic;Time;United States National Institutes of Health;Universities;user-friendly;Validation;Vertebral column;Visit;web site

PROJECT_TITLE: Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis Consortium


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: MicroRNA isoforms (isomiRs), tRNA-derived fragments (tRFs), and rRNA-derived fragments (rRFs) are important classes of regulatory RNAs most of whose members are uncharacterized. To help researchers study these molecules, we will build a) specialized tools to correctly mine these small RNAs from human and mouse deep sequencing data, and b) specialized databases to organize, and make available, knowledge about these small RNAs that we will distill from tens of thousands of NIH SRA datasets. To help researchers keep up with the fast pace of the field, we will also build c) a “hands-free” system that will update these databases by automatically mining each month newly-added datasets to NIH’s SRA.

PI_NAMEs: RIGOUTSOS, ISIDORE  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Access to Information;Accounting;Address;Age;Animals;Archaea;Attention;Bacteria;breast cancer metastasis;Categories;Cell Physiology;Cells;Data;Data Set;Databases;deep sequencing;Diagnostic;Disease;Educational Materials;Educational workshop;Experimental Designs;Feedback;fungus;Genetic;Genome;Hand;Health;health disparity;Human;Human Biology;Human Genome;improved;Infrastructure;insight;interest;Internet;Knowledge;Link;Literature;member;Messenger RNA;Metadata;MicroRNAs;Mining;Molecular and Cellular Biology;Mouse Strains;Mus;Neoplasm Metastasis;novel;Nuclear;Organism;Patients;Pattern;Personal Attribute;Plants;Preparation;Property;Protein Isoforms;Proteins;prototype;Publishing;Reaction Time;Reporting;repository;Research Personnel;Ribosomal RNA;RNA;Role;Sequence Read Archive;sex;Small Interfering RNA;Small RNA;Specificity;Suggestion;System;Techniques;telomere;Testing;therapeutic target;Tissues;tool;Training;Transcend;transcriptome sequencing;Transfer RNA;United States National Institutes of Health;Update;user-friendly;Validation;Visualization software;Work;Writing

PROJECT_TITLE: Specialized Tools and Auto-updatable Scalable Interactive Databases to Study isomiRs, tRFs and rRFs in Human and Mouse

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: The ultimate long-term objective of the Career Enhancement Program (CEP) is to develop novel ways to reduce the burden of ovarian cancer, through translational, clinical, and population-based research. A prerequisite for achieving this objective is a continual influx of newly independent researchers with interest, experience, and expertise in ovarian cancer. The CEP of the Roswell Park Ovarian Cancer SPORE will support the career development of the next generation of translational ovarian cancer researchers.

PROJECT_TERMS: Advocate;anti-cancer research;Applications Grants;Award;Awareness;Caliber;Cancer Research Project;career;career development;Clinical;Comprehensive Cancer Center;Data;Data Set;Development;Disabled Persons;Disease;Epidemiologist;Ethnic Population;experience;Extramural Activities;Faculty;Foundations;Funding;Future;Goals;Grant;Group Meetings;Historically Black Colleges and Universities;Immunologist;Individual;Institution;interest;International;Leadership;Malignant neoplasm of ovary;Malignant Neoplasms;meetings;Mentors;Mentorship;next generation;novel;Nursing Faculty;Patients;Periodicals;population based;Population Programs;Population Research;Postdoctoral Fellow;Process;professor;programs;racial population;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Running;Series;Site;Specimen;Structure;Study Section;Talents;Target Populations;Tissues;Training Programs;translational cancer research;translational impact;tumor;Underrepresented Minority;United States National Institutes of Health;Universities;University of Pittsburgh Cancer Institute;Woman;Work

PROJECT_TITLE: Career Enhancement Program


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: ZFX is a transcriptional activator with large effects on the human transcriptome in multiple cell lines. Despite preliminary data from the Farnham Lab that demonstrates almost complete overlap of ZFX binding to thousands of promoter regions in several cell lines, the sets of genes activated by ZFX are surprisingly unique to each cell line. To determine how ZFX regulates cell type-specific gene expression while binding to the same set of promoters, this proposal will identify ZFX protein binding partners and other transcription factors bound to promoters of ZFX regulated genes in multiple cell lines.

PI_NAMEs: HSU, EMILY  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Affect;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological Assay;Biotinylation;C2H2 Zinc Finger;Canada;candidate identification;candidate validation;cdc Genes;Cell Line;cell type;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;CpG Islands;Data;Disease;DNA-Binding Proteins;Down-Regulation;experimental study;Family;Family member;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Health;Human;Human Cell Line;human disease;In Situ;Individual;insight;knock-down;Knock-out;Label;Learning;Ligation;Malignant Neoplasms;Maps;Mass Spectrum Analysis;MCF7 cell;Mediating;Mediator;Mentors;Messenger RNA;Methods;Molecular Biology;Molecular Biology Techniques;mutant;Mutate;Mutation;N-terminal;Nuclear Proteins;Oncogenic;Pattern;Peptides;Physicians;Proliferating;promoter;Promoter Regions;protein protein interaction;Proteins;Proteomics;Proto-Oncogene Proteins c-myc;Publishing;Quantitative Reverse Transcriptase PCR;Regulation;Research;Site;Small Interfering RNA;Techniques;Testing;Training;Transactivation;Transcription Coactivator;transcription factor;Transcription Initiation Site;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumorigenesis;Universities;ZFY protein

PROJECT_TITLE: How does the ubiquitously expressed ZFX mediate cell type-specific transcriptional regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative The overall objective of the proposed studies is to determine the role of endothelial FTO in the mechanisms of pulmonary vasoconstriction and vascular remodeling and thereby provide novel therapeutic approaches for effective treatment of PAH and promote survival.

PI_NAMEs: ZHAO, YOU-YANG  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adenosine;Adult;Affect;alpha ketoglutarate;Animal Model;Area;arginase;Arginine;bioprocess;Cessation of life;Chronic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;Data;demethylation;Dioxygenases;Disease;druggable target;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;fat mass and obesity-associated protein;FDA approved;Functional disorder;Gene Expression;Gene Transfer;Genes;Goals;Human;human disease;Hypoxia;Impairment;improved;in vivo;inhibitor;insight;Interleukin-6;Knockout Mice;Link;Lung;lung microvascular endothelial cells;Malignant Neoplasms;Maps;Meclofenamic Acid;Mediating;Messenger RNA;Metabolism;methyl group;Modeling;Modification;Molecular;Monocrotaline;Morbidity - disease rate;mortality;mRNA Stability;Mus;mutant;nanoparticle;new therapeutic target;next generation sequencing;Nitric Oxide;novel;novel therapeutic intervention;novel therapeutics;Obesity;Pathogenesis;Patients;PDGFB gene;Pharmaceutical Preparations;pharmacologic;Phenotype;Platelet-Derived Growth Factor;Post-Transcriptional Regulation;premature;Prevention;primary pulmonary hypertension;Protein Deficiency;Proteins;Protocols documentation;pulmonary arterial hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;pulmonary vasoconstriction;Rattus;Regulation;Regulator Genes;Research;resistance gene;response;right ventricular failure;RNA;RNA metabolism;RNA Stability;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Site;Stimulus;Stromal Cell-Derived Factor 1;Structure of parenchyma of lung;synergism;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic evaluation;Time;Transcription Coactivator;transcription factor;translational potential;Translations;Vascular remodeling;vasoconstriction

PROJECT_TITLE: Novel roles of RNA modifications in the pathogenesis of pulmonary vascular remodeling and PAH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative We propose to develop and demonstrate the clinical imaging performance of high resolution, clinical time-of- flight positron emission tomography detectors that achieve 100 ps FWHM coincidence time resolution. This detector technology can facilitate PET systems with substantially enhanced reconstructed image signal-to-noise ratio and contrast-to-noise ratio, which can be exploited to improve lesion detection and quantification, or greatly reduce injected radiation dose or scan duration, making PET more accurate, safe, and practical across a wide variety of imaging studies.

PI_NAMEs: CATES, JOSHUA WILLIAM (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Scintillation Photon Counting Detectors for 100 ps Time-of-Flight PET Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: San Francisco

ORG_NAME: SPIKEGADGETS, LLC

PHR: This project aims to provide a commercial alternative to the Neuropixels probe and associated electronics that will enable feature parity in recording capability, but also be usable in scientific applications currently unaddressed by the existing Neuropixels probe. By coupling the proposed probe to powerful datalogging electronics, we will offer a way to scale channel counts to above 3000 without the need for cables between the animal and a computer.

PI_NAMEs: FRANK, LOREN M;KARLSSON, MATTIAS PETER (contact);XIE, CHONG ;ZIMMERMANN, JAN

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TITLE: Commercialization of integrated electrode-electronics system for large scale, long-lasting electrophysiology


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative The protein BRAF is a key switch in a signaling pathway that controls cell growth and proliferation, and mutations that activate this switch are a frequent cause of cancer. We are working to understand how this switch works, how cancer drugs that target it and its partner MEK interact with it, and how cancer-causing mutations alter its structure. In the long term, our work should lead to more effective and less toxic treatments for cancers caused by BRAF mutations.

PI_NAMEs: ECK, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Antineoplastic Agents;Biochemical;Biophysics;BRAF gene;Cancer Etiology;cancer therapy;cell growth;Cell Proliferation;Complex;Confusion;Cryoelectron Microscopy;drug discovery;Drug Targeting;Epidermal Growth Factor Receptor;Exhibits;Goals;Human;inhibitor;insight;interest;Investigation;Knowledge;KRAS2 gene;Laboratories;Malignant Neoplasms;MAP Kinase Gene;MEKs;Melanoma;Mitogen-Activated Protein Kinases;mutant;Mutation;New Agents;Pathway interactions;pharmacologic;Pharmacology;Phosphotransferases;Protein Kinase;Proteins;Ras/Raf;receptor;reconstitution;Regulation;resistance mechanism;Signal Pathway;structural biology;Structure;targeted agent;targeted treatment;Work

PROJECT_TITLE: Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: The proposed intergenerational research study would increase our understanding of cognitive resilience in late-life older adults, and examines the relation of midlife biomarkers of brain and cardiovascular health in offspring and cognitive resilience in parent. Preserving cognitive resilience through early, mid, and late life biomarkers is a topic of high public health significance, since designing of preventive strategies through life course can offer stronger potential for slowing or reducing the risk of developing cognitive loss in late-life.

PI_NAMEs: EVANS, DENIS A;RAJAN, KUMAR B. (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Affect;African American population;Age;aged;Aging;aging population;aging process;Alleles;Alzheimer's Disease;American;apolipoprotein E-4;Area;Autopsy;Biological Markers;biracial;Body mass index;Brain;brain health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Chicago;Clinical;Cognition;Cognitive;cognitive ability;cognitive change;cognitive function;cognitive performance;cognitive testing;cohort;Data;Data Analyses;dementia risk;depressive symptoms;design;Early identification;early life adversity;Economics;Elderly;Enrollment;epidemiologic data;Epidemiology;Ethnic Origin;Female;Femur;follow-up;Gender;General Population;Generations;gray matter;Health;High Prevalence;Hippocampus;human old age (65+);Impaired cognition;improved;Incidence;indexing;Injury;intergenerational;Intergenerational Relations;late life;Life Cycle Stages;life span;Magnetic Resonance Imaging;Measures;middle age;Minority Groups;Modeling;modifiable risk;neuroimaging;neuroimaging marker;neuropathology;Neurotic Disorders;novel;Occupations;offspring;older adult;Older Population;Parents;Participant;performance tests;Personality Traits;Persons;Pharmaceutical Preparations;Phase;Physical Function;Physiologic pulse;Population;Population Study;preservation;prevent;Prevention strategy;protective factors;psychologic;Public Health;Race;racial difference;racial population;recruit;Research;research study;Residual state;resilience;resilience in aging;resilience research;response;Risk Factors;Risk Reduction;Sampling;Schools;sex;slow potential;social;social factors;Social Network;Testing;white matter;Work

PROJECT_TITLE: Preserving Cognitive Resilience:  A Biracial Parent-Offspring Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  African Americans have the highest incidence and mortality rates from colorectal cancer over any other major racial or ethnic group in the United States, but it is not fully clear what drives the aggressiveness of disease in these patients. We discovered that pro-inflammatory cytokines like IL6 are persistently released during inflammation and directly impede specific repair processes centered around the DNA mismatch repair protein MSH3 such that subsequent mutations within DNA accumulate, and associates with poor patient outcome. We aim to understand the contribution of MSH3 dysfunction to the poor survival outcome of African American colorectal cancer patients.

PI_NAMEs: ASHKTORAB, HASSAN ;CARETHERS, JOHN M (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: 9p24;African American;African American population;Aneuploidy;Biological Process;Caucasians;Cell Nucleus;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;colon cancer patients;Colorectal Cancer;Copy Number Polymorphism;cytokine;Cytosol;Data;Death Rate;Defect;Disease;Disparity;DNA;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Ethnic Origin;Ethnic Population;Functional disorder;Genes;homologous recombination;Impairment;Incidence;Inflammation;Inflammatory;Interleukin-6;loss of function;Loss of Heterozygosity;Malignant Neoplasms;Microsatellite Repeats;mismatch repair protein 1;MLH1 gene;mortality;MSH2 gene;MSH3 gene;MSH6 gene;Mutation;novel;patient retention;Patient-Focused Outcomes;Patients;Phenotype;PMS2 gene;prevent;Process;Proteins;public database;Race;racial population;Rectal Cancer;repaired;Reporting;Role;Signal Transduction;survival outcome;Testing;Tetranucleotide Repeat;United States

PROJECT_TITLE: Inactivation of MSH3 in Colorectal Cancer and Race

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE African American (AA) older adults have more than twice the prevalence of Alzheimer's disease and related dementias (ADRD) compared to non-Latinx White older adults; thus, there are more AA caregivers. Formal care (paid care services for older adults usually associated with a healthcare institution) is essential to the treatment and management of ADRD and associated with better quality of life, and African American adult daughters, the largest group of caregivers of African American persons living with dementia, must navigate decision-making related to formal care. This project seeks to identify key factors associated with the formal care decision-making process for African American persons living with ADRD and to improve the quality of life of African American parent-adult daughter dementia dyads by designing and testing a structured prototype intervention to support these dyads and their families with the formal care decision-making process.

PI_NAMEs: JOHNSON, KALISHA BONDS (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Achievement;Address;Adult Children;Affect;African American;African American population;African American Women;Alzheimer's disease related dementia;Area;Behavioral;behavioral and social science;Black race;care giving burden;care systems;Caregiver research;Caregivers;caregiving;Caring;Clinical Trials;Communication;Community Outreach;contextual factors;Data;Daughter;Decision Making;Dedications;Dementia;Dementia caregivers;dementia caregiving;design;Development;Evaluation;exhaust;experience;Family;feasibility testing;Foundations;Future;Gender;Goals;Health Disparities Research;health disparity;Health Status;Health system;Healthcare;improved;informal caregiving;informant;Institution;Intervention;intervention mapping;Intervention Studies;Intervention Trial;Interview;lens;literacy;Lived experience;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;Modeling;Morbidity - disease rate;multidisciplinary;multilevel analysis;National Institute on Aging;Nurses;older adult;outcome disparities;Parents;Persons;Population Heterogeneity;Prevalence;Problem Solving;Process;programs;prototype;Quality of life;Race;racial population;recruit;Research;Research Personnel;Risk;Role;Sampling;Scientist;skill acquisition;social;social culture;Source;Spouse Caregiver;Structure;Surveys;Symptoms;System;Testing;therapy design;therapy development;Thinking;Training;United States National Institutes of Health;Variant;Voice;welfare

PROJECT_TITLE: Designing a Culturally Tailored Formal Care Decision-Making Intervention for African American Dementia Dyads and Families

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Young adult drinkers with attention-deficit/hyperactivity disorder (ADHD), compared to their non-ADHD peers, are at increased risk for experiencing alcohol-related problems and developing alcohol use disorder (AUD). The proposed project assesses individuals both in the laboratory and in their own natural environment to study associations between executive functioning, craving, and alcohol-related behaviors over a one-year period to inform etiological models underlying ADHD and AUD. Findings will identify opportunities to tailor prevention and intervention approaches aimed to reduce alcohol-related risks for young adults with ADHD.

PI_NAMEs: STAMATES, AMY  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;Affect;Age;Alcohol abuse;alcohol behavior;alcohol comorbidity;Alcohol consumption;alcohol craving;alcohol intervention;alcohol measurement;alcohol related problem;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Attention;Attention deficit hyperactivity disorder;Automobile Driving;Award;career development;Clinical;contextual factors;craving;Data;Data Analyses;design;Development Plans;Diagnosis;drinking;Ecological momentary assessment;Educational workshop;Environment;Etiology;Event;Executive Dysfunction;executive function;experience;Gender;Glass;Goals;Impulsivity;Individual;innovation;Intervention;Knowledge;Laboratories;Location;Maintenance;Measurement;meetings;Mental disorders;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;Outcome;Outcome Assessment;Participant;peer;peer influence;Persons;Population;Populations at Risk;Predisposition;Prevention;Process;programs;Relapse;Research;Research Support;Resources;Rewards;Risk;Scientist;Severities;sex;skills;social;social factors;Strategic Planning;Substance Use Disorder;symposium;theories;therapy development;Time;Training;young adult

PROJECT_TITLE: ADHD and Alcohol Use: A Longitudinal Examination of Dual Processes

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Alzheimer’s disease is a neurodegenerative disorder characterized by protein aggregation and cognitive decline and patients with Alzheimer’s disease can experience neuropsychiatric symptoms including hallucinations and delusions, which are also characteristic of schizophrenia. We recently discovered that protein insolubility is increased in a subset of postmortem brains from patients with schizophrenia and therefore, hypothesize that the overlapping proteomic changes associated with protein aggregation in schizophrenia and Alzheimer’s disease will implicate genes and proteins, and thus specific cellular processes, associated with neuropsychiatric symptoms and psychosis observed in Alzheimer’s disease. This proposal may provide evidence that the mechanisms responsible for aggregation in schizophrenia contribute to the neuropsychiatric symptoms that occur in Alzheimer’s disease, particularly those observed in women.

PI_NAMEs: NUCIFORA, LESLIE GISELLE (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;associated symptom;Autophagocytosis;Autopsy;Axon;Biogenesis;Bioinformatics;Biological;Biostatistical Methods;Brain;brain dysfunction;Cell Physiology;Cells;Characteristics;Clinical;Cognition;comparison control;Computing Methodologies;Data;Delusions;Development;Diagnosis;Disease;Etiology;experience;Female;Fractionation;Functional impairment;Genes;Genetic Risk;genome wide association study;Genomic approach;genomic data;Genomics;Hallucinations;Impaired cognition;insight;Mass Spectrum Analysis;men;Mentored Research Scientist Development Award;mortality;Neurobiology;Neurodegenerative Disorders;neuron loss;Neurons;neuropsychiatric symptom;neuropsychiatry;new therapeutic target;Onset of illness;Outcome;Pathogenesis;Pathology;Patients;Process;protein aggregation;Proteins;Proteome;Proteomics;Protocols documentation;psychiatric symptom;Psychoses;psychotic symptoms;Research;Research Personnel;Schizophrenia;sex;Sex Differences;Symptoms;Testing;therapeutic target;Training;Woman;women patients;women versus men;Women's prevalence;Work

PROJECT_TITLE: A Proteomic and Genomic Approach to Understanding Neuropsychiatric Symptoms in Alzheimer's Disease

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: The spread of tuberculosis is a global health crisis leading to over one million deaths annually. The global burden of tuberculosis is a threat to the health of all Americans, and directly relevant to the mission of the National Institute of Allergy and Infectious Diseases, given the easy transmission of the disease through the air and the emergence of drug resistant strains that are difficult to treat. Moreover, there exists an increasing population of Americans with enhanced susceptibility to TB due to factors associated with compromised immune systems, including: HIV infection, the use of anti-rejection and anti-inflammatory drugs, as well as natural decreases in immunity associated with an aging population.

PI_NAMEs: ABRAMOVITCH, ROBERT B (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: aging population;Air;American;Amino Acids;Animal Model;Anti-Inflammatory Agents;Antibiotics;Bacteria;Biochemical;Biological;C3HeB/FeJ Mouse;Carbon Monoxide;Cause of Death;Cavia;Cells;Cessation of life;chemical genetics;Chemicals;Communicable Diseases;CRISPR interference;Data;Development;disease transmission;drug action;Drug resistance;Drug Tolerance;Evolution;Genes;genetic approach;Genetic Screening;genetic selection;Genetic study;global health;Goals;Granuloma;Health;heme a;Heme Group;HIV Infections;Hypoxia;Immune;Immune system;Immunity;In Vitro;in vivo;Infection;inhibitor;innovation;Libraries;Mission;Modeling;Multidrug-Resistant Tuberculosis;Mus;mutant;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Nitric Oxide;non-compliance;nonhuman primate;Oryctolagus cuniculus;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Physiology;Population;Predisposition;pressure;Regimen;Relapse;Reporter;Resistance;resistant strain;response;sensor;side effect;Signal Transduction;small molecule;Structure-Activity Relationship;System;tool;Triglycerides;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Virulence

PROJECT_TITLE: Chemical genetics of M. tuberculosis DosRST signaling and persistence

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: This application tackles the novel idea that coupling between KCC3a, pendrin, and NCC maintains potassium and acid-base balance in response to the consumption of alkaline and potassium-rich foods but drives potassium wasting in alkalosis. KCC3a-mediated potassium secretion will be reduced in distal nephron-specific KCC3a knockout mice but increased in distal nephron-driven pendrin knockout animals, and in Gitelman syndrome. Consumption of an alkaline-rich diet stimulates phosphorylation of the Na-Cl cotransporter, NCC, leading to increased Na+ and Cl- reabsorption and maximizing the secretion of K+ through KCC3a.

PI_NAMEs: DELPIRE, ERIC J (contact);WALL, SUSAN MARIE;WELLING, PAUL A

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Ablation;absorption;Acid-Base Equilibrium;Alkalosis;Animals;Anions;Apical;apical membrane;Bicarbonates;Cell membrane;Cell model;Cellular biology;chloride-cotransporter potassium;Chlorides;clinical care;Consumption;Coupling;Data;Diet;dietary;Dietary Potassium;Distal;Distal convoluted renal tubule structure;Ensure;Equilibrium;Excretory function;Food;Genes;Genetic Transcription;Genetically Engineered Mouse;Gitelman syndrome;Homeostasis;In Vitro;in vitro Model;in vivo;inhibitor;innovation;Intake;Intercalated Cell;interdisciplinary approach;Investigation;Kidney;knockout animal;Knockout Mice;Knowledge;Link;Mediating;Metabolic;Modeling;Molecular;mouse model;multidisciplinary;Mus;Nephrons;novel;novel therapeutics;Pathway interactions;Persons;Phenotype;Phosphorylation;Physiological;Physiology;Potassium;potassium bicarbonate;preservation;prevent;programs;Proteins;Public Health;Publishing;Recycling;Regulation;response;Role;SLC12A3 gene;Sodium;Sodium Chloride;symporter;Syndrome;targeted treatment;Testing;Textbooks;Therapeutic Intervention;thiazide;Translations;urinary;Variant;Vegetarian diet;wasting;Wild Type Mouse

PROJECT_TITLE: Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Acute Respiratory Distress Syndrome;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lung;Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Patients with acute respiratory failure (ARF) experience delirium and cognitive impairments. The role of reactive oxygen species (ROS) in cognitive impairment is not well understood. To address this knowledge gap, we propose to study the relationship among ROS, delirium, and cognitive impairment in patients with ARF.

PI_NAMEs: KHAN, SIKANDAR HAYAT (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Acute;Acute respiratory failure;Address;Admission activity;Adult;age acceleration;Aging;Alveolar;Alzheimer's Disease;Alzheimer's disease related dementia;Astrocytes;Award;Biological;Biological Markers;Blood specimen;career;career development;Circulation;Clinical Research;Clinical Sciences;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Critical Illness;cytokine;Delirium;Development Plans;effective therapy;Endothelium;Enrollment;Environment;experience;Extravasation;Faculty;Functional disorder;Funding;Geroscience;Goals;Health;Impaired cognition;Impairment;improved;Indiana;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Institutionalization;Intensive Care Units;Interleukin-6;Interleukins;K-Series Research Career Programs;Knowledge;Leadership;Learning;leukocyte activation;Lipids;Lung;Measures;Mechanical ventilation;medical schools;meetings;Mentors;Mentorship;mild cognitive impairment;mortality;multidisciplinary;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic Dysfunctions;Neuronal Injury;older adult;Outcome;Outcome Study;Outcomes Research;oxidative damage;Oxidative Stress;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Peripheral;Pharmacological Treatment;Physical Function;physical impairment;Plasma;Play;postoperative delirium;preclinical study;Prevalence;Production;prospective;Prospective Studies;Prospective, cohort study;Proteins;Quality of life;Reactive Oxygen Species;Recovery;Research;Research Personnel;Resources;Respiratory Failure;Risk;Role;Sampling;Severities;skills;success;Survivors;Testing;Time;TNF gene;Training;Translational Research;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Reactive Oxygen Species in Respiratory Failure, Delirium, and Post-ICU Cognitive Impairment


NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Pain Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Most patients with chronic pancreatitis experience severely debilitating pain. Unfortunately, only ~25% of these chronic pancreatitis patients achieve meaningful pain relief with current standard of care for pain management, highlighting the urgent need for objective biomarkers to stratify pain type and pain severity. This proposal is designed to discover (Specific Aims 1 and 2) and validate (Specific Aims 3 and 4) such pain biomarkers in plasma and/or urine, which have the potential to significantly improve pain management for chronic pancreatitis patients so that the majority can enjoy a meaningful pain relief.

PI_NAMEs: SALOMAN, JAMI LYNN;STEEN, HANNO  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: acute pancreatitis;Address;Antibodies;Arthritis;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker validation;Blood;Calcitonin Gene-Related Peptide;candidate marker;chemokine;Chronic;chronic pain management;chronic pancreatitis;Clinical;clinically relevant;cohort;Complications of Diabetes Mellitus;cytokine;Data;debilitating pain;Decision Making;Dedications;design;Diabetes Mellitus;diagnostic criteria;Disease;Endoscopy;Enrollment;epidemiology study;Evaluation;Exocrine pancreatic insufficiency;experience;Fibrosis;Funding;Hand;Home;IL6ST gene;improved;Inflammation;insight;Interstitial Cystitis;Intervention;Knowledge;Leadership;Letters;liquid chromatography mass spectrometry;Malignant neoplasm of pancreas;Maps;Mass Spectrum Analysis;member;Methods;molecular marker;Monitor;Multiomic Data;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Nerve Growth Factors;Neuropathy;Neuropeptides;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Opioid;Pain;Pain management;pain relief;Pancreas;Pancreatic Diseases;Pancreatitis;Participant;patient population;Patients;Pelvis;Phase;Phenotype;Physicians;Plasma;Plasma Proteins;Platelet-Derived Growth Factor;potential biomarker;prospective;Proteins;Proteomics;Quality of life;Recurrence;Research Personnel;Resources;Sampling;secondary analysis;Serum;Set protein;Severities;Site;standard of care;success;Symptoms;Syndrome;Testing;Transforming Growth Factor beta;translational study;treatment response;Up-Regulation;urinary;Urine;Validation;validation studies;Visceral pain

PROJECT_TITLE: Biomarkers to stratify pain severity and type in pancreatic disease

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PASADENA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This project aims to develop a laser-engraved wearable molecular sensing patch that can continuously monitor a panel of key cardiometabolic biomarkers. This project spans across chemistry, engineering, cardiovascular medicine, and clinical nutrition to explore the novel method of monitoring key cardiometabolic biomarkers in patients with pre-diabetes and obesity. This platform has the potential to modulate the patient-specific cardiometabolic risk factors in the pre-diabetic and obese individuals, with translational significance to mitigate clinical manifestation of major adverse cardiovascular events.

PI_NAMEs: GAO, WEI  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acceleration;Adult;Affect;Antibodies;Biological Markers;Biosensing Techniques;Biotechnology;Blood;Branched-Chain Amino Acids;Calibration;Cardiology;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cessation of life;Chemistry;Chronic;Clinical;Clinical Nutrition;clinically relevant;clinically significant;Collaborations;COVID-19 pandemic;Cystic Fibrosis;design;Detection;Diabetes Mellitus;Diagnosis;Dietary Intervention;Disease;Electrolytes;Engineering;Engravings;Epigenetic Process;evaporation;Event;Fatty Liver;Generations;Genetic;Glucose;Goals;Gold;Gout;graphene;high risk;Home;Human;Hyperlipidemia;Hypertension;imprint;In Situ;Institutional Review Boards;Insulin;Intervention;ischemic cardiomyopathy;Isoleucine;Joints;Lasers;Leucine;Liquid substance;manufacturing cost;Measurement;Medicine;Metabolic;Metabolic Diseases;Metabolic syndrome;Methods;Microfluidics;Molecular;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;nano;nanoengineering;Natural regeneration;Nature;Non-Insulin-Dependent Diabetes Mellitus;Non-Invasive Detection;non-invasive monitor;novel;nutrition;obese patients;obese person;Obesity;Obesity Epidemic;Pathogenesis;Patient Monitoring;Patients;personalized health care;Physical activity;Physiologic Monitoring;Physiological;Population;Potassium;Prediabetes syndrome;Prevention;Protocols documentation;Publications;Reduce health disparities;remote screening;Research;Risk;Risk Factors;Sampling;screening;sensor;simulation;Stroke;System;Techniques;Temperature;temporal measurement;Testing;Uncertainty;Uric Acid;Valine;wearable device;wearable sensor technology;wireless;wireless sensor

PROJECT_TITLE: Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project narrative Infections caused by the opportunistic fungal pathogen Aspergillus fumigatus range from a chronic inflammatory and fibrotic process known as chronic pulmonary aspergillus to an acute life-threatening pneumonia known as invasive aspergillosis. This study will employ newly developed model systems to understand how lung fibroblasts coordinate with the immune system to protect the lung from this infection, with the long-term goal of using this information as a foundation to develop novel treatment strategies to enhance pulmonary defenses.

PI_NAMEs: ASKEW, DAVID S (contact);KANISICAK, ONUR

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Ablation;Acute;Acute Respiratory Distress Syndrome;Affect;Allergic Bronchopulmonary Aspergillosis;Aspergillosis;Aspergillus;Aspergillus fumigatus;Atmosphere;Behavior;Biological Models;Blood capillaries;Cell Differentiation process;cell type;Chronic;Complication;Connective Tissue;COVID-19;cytokine;Data;Dendritic Cells;Development;Disease;Effectiveness;Environment;Enzymes;Epithelium;Exposure to;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;Foundations;Fright;fungus;Gene Expression Profile;Genetic;Genetic Models;Genetic Transcription;Geographic Locations;Germination;Goals;Grant;Growth Factor;Hematogenous;Hematopoietic stem cells;Host Defense;Host Defense Mechanism;Human;Hyphae;Immune;Immune system;Immunocompetent;immunological status;immunoregulation;immunosuppressed;Immunosuppression;improved outcome;in vivo;Incidence;Individual;Infection;Inflammatory;Inflammatory Response;Inhalation;Innate Immune System;interstitial;Knowledge;Life;Light;long-term sequelae;Lung;Lung infections;lung injury;lung pathogen;Macrophage;Mediator;Molds;mouse genetics;mouse model;Mus;Myelogenous;Myeloid Cells;novel;novel therapeutic intervention;Opportunistic Infections;Organ Transplantation;Outcome;Outcome Study;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;Pathology;Patients;Pneumonia;Population;Process;Production;Pulmonary Fibrosis;Pulmonary vessels;Reaction;repaired;Reproduction spores;respiratory;response;response to injury;Severities;Solid;Structural defect;Structure of parenchyma of lung;Testing;Tissues;Transplantation;treatment strategy

PROJECT_TITLE: Aspergillus fumigatus infection and fibrosis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PI_NAMEs: ERTEKIN-TANER, NILUFER  (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Active Learning;Address;Appointment;career development;Charge;Clinic;Clinical Competence;Clinical Research;Clinical Sciences;Communities;community building;Competence;Development Plans;Discipline;Doctor's Degree;Education;educational atmosphere;Educational Curriculum;Elements;Environment;experience;Extramural Activities;Faculty;faculty mentor;Fostering;Funding;improved;Individual;innovation;Institution;Lead;Leadership;Learning;Mentors;Mentorship;multidisciplinary;novel strategies;peer;Process;Program Development;Program Evaluation;programs;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Role;Science;sex as a biological variable;skills;social media;Structure;success;Training;Translational Research;translational scientist;visiting scholar

PROJECT_TITLE: Institutional Career Development Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Prospective memory failures represent a significant public health issue because medicine nonadherence is associated with poor treatment outcomes, disease progression, and billions of dollars annually in avoidable direct healthcare costs. Education and instruction on how to offload prospective memory intentions onto the environment rather than relying one’s own memory ability will improve healthcare outcomes and quality of living for older adults. This work aligns with NIH’s mission because offloading represents an easy and effective method to reduce prospective memory errors in healthy older adults and individuals with Alzheimer’s disease and related dementias.

PI_NAMEs: BALL, BRETT HUNTER (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Adult;adverse drug reaction;Age;age difference;age related;age related decline;Age-associated memory impairment;aging population;Alzheimer's disease related dementia;Attention;attentional control;Awareness;behavior measurement;Behavioral;care outcomes;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive process;Communities;Development;Diameter;Disease Progression;Education;Educational Intervention;Educational process of instructing;effectiveness testing;Environment;Expenditure;experience;experimental study;Failure;functional independence;Future;Generations;Goals;Health;Health Care Costs;healthy aging;Hospitalization;improved;indexing;Individual;individualized medicine;innovation;Instruction;instrumental activity of daily living;Intention;Knowledge;Laboratories;Learning;locus ceruleus structure;long term memory;Low income;Maintenance;Measures;Medicine;Memory;memory encoding;Memory Loss;memory process;metacognition;Methods;Mission;norepinephrine system;novel;older adult;Older Population;Participant;Performance;Pharmaceutical Preparations;Physiological;Process;prospective memory;Public Health;Pupil;rehearsal;Research;Research Personnel;Retrieval;Role;Source;Speed;Students;success;Techniques;Testing;theories;Time;tool;Training;Treatment outcome;undergraduate student;United States National Institutes of Health;Work;young adult

PROJECT_TITLE: Using Cognitive Offloading to Mitigate Age-Related Declines in Prospective Memory


PHR: Project Narrative Capsular polysaccharides (CPSs), by which most pathogenic bacterial surfaces are decorated, have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical practice worldwide. Due to inadequate understanding of how the immune system interacts with these complex vaccines, their design and production have often been empirical, yielding poorly characterized, heterogeneous, and variably immunogenic vaccines, with poor immune responses in high-risk populations such as the elderly and patients with weak immune systems. Through the mechanistic knowledge attained in this project, we propose to establish a new-generation vaccine development platform to produce knowledge-based vaccines that are target-specific, structurally designed, highly immunogenic, and protective, produced at much lower cost and allowing much wider use on a global scale than current vaccines to control or eliminate a wide variety of infectious diseases.

PI_NAMEs: AVCI, FIKRI Y (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Affinity;Antibodies;Antibody titer measurement;Antigen-Presenting Cells;Antigens;B-Cell Activation;B-Lymphocytes;Bacteria;Bacterial Infections;Benchmarking;Binding;Biological Assay;Carbohydrates;Carrier Proteins;CD4 Positive T Lymphocytes;Cells;chemical conjugate;Chemistry;Clinical;clinical efficacy;clinical practice;clinical predictors;Communicable Diseases;Complex;Conjugate Vaccines;cost;Coupling;cross reacting material 197;Data;depolymerization;design;Elderly;Epitopes;Funding;Future;Generations;Glycoconjugates;Health Benefit;Helper-Inducer T-Lymphocyte;high risk population;Human;Humoral Immunities;Immune;immune activation;Immune response;Immune system;Immunity;Immunization;immunogenic;immunogenicity;Immunoglobulin Class Switching;Immunoglobulin G;Immunologic Surveillance;improved;In Vitro;in vivo;Investigation;Knowledge;Maps;Measures;Mediating;Memory B-Lymphocyte;Methods;microorganism;Modeling;Modification;Molecular;Mus;novel;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Peptides;Plasma Cells;polypeptide;Polysaccharides;Population;Process;Production;Publishing;Research;response;Serotyping;Streptococcus pneumoniae;Structure;success;Surface;Surface Antigens;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;vaccination outcome;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine platform;Vaccine Research;vaccine strategy;Vaccines;Work

PROJECT_TITLE: Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII Pathway

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: When we encounter a virus or a tumor in our body, we use specialized sensors to detect these threats. One of these sensory pathways recognizes the DNA within viruses or tumors, and alerts our immune system to attack the threat. Our goal is to understand how DNA-sensing works and control it to improve immune health.

PI_NAMEs: HACOHEN, NIR  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Affect;Alleles;Autoimmunity;Autophagocytosis;Autophagosome;Biochemical;Biology;Cell Death;Cell model;Cells;Central Nervous System;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Development;disease-causing mutation;DNA;Endosomes;Factor Analysis;Genes;genome-wide;Goals;Golgi Apparatus;Hereditary Spastic Paraplegia;Human;human disease;Human Pathology;Immune;immune activation;immune health;Immune system;Immunity;improved;Inflammation;Inherited;Interferons;IRF3 gene;Knock-out;Knowledge;Ligands;Ligation;Lysosomes;Malignant Neoplasms;Mediating;Mitochondria;Modeling;mutant;Mutate;Mutation;mutation screening;neoplastic cell;novel;Nuclear;nuclease;Optical Methods;pathogen;Pathogenicity;Pathway interactions;Pattern;Process;Proteins;Proteomics;pseudotoxoplasmosis syndrome;recruit;Regulation;Resolution;response;Role;seal;sensor;Sensory;Signal Transduction;Site;Stimulator of Interferon Genes;TBK1 gene;Testing;Therapeutic;trafficking;TREX1 gene;tumor;Tumor Immunity;ubiquitin-protein ligase;Ubiquitination;Vaccines;Vascular Diseases;Virus;Virus Diseases;Work

PROJECT_TITLE: Factors regulating strength and duration of STING signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  The study of persons with or at-risk for autosomal dominant Alzheimer’s disease (ADAD) had made significant contributions to our understanding of AD in general. In collaboration with investigators in Mexico, we have identified a large number of families there with this otherwise rare form of AD. Therefore, there is a substantial population of persons with or at-risk for ADAD available for and motivated to participate in research. To date, little systematic research has been performed in this population in Mexico, in part due to a lack of resources and infrastructure. In this project we propose to facilitate research in ADAD in Jalisco state by providing the technology for research and clinical genetics as well as funding and training to develop a cohort that will prospectively be followed using standardized clinical and cognitive measures, enabling additional research studies.

PI_NAMEs: RINGMAN, JOHN M (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Adult;Advocacy;Affect;Age;Age of Onset;Alzheimer's Disease;Amyloid Beta A4 Precursor Protein;autosomal dominant Alzheimer's disease;autosome;behavioral phenotyping;C9ORF72;California;Clinic;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Cognitive;cognitive testing;cohort;Collaborations;Colombia;CSF1R gene;Data Set;Development;Disease;disease phenotype;disease-causing mutation;Elements;Ethics;Evaluation;evidence base;exome sequencing;Extended Family;familial Alzheimer disease;Family;Founder Effect;Functional disorder;Funding;Future;Gender;Genes;Genetic;Genetic Counseling;Genetic Predisposition to Disease;Genetic Screening;Genetic study;genetic testing;genetic variant;Genotype;Goals;Impaired cognition;improved;Infrastructure;International;Intervention;Leg;Measures;Medical Genetics;Mentorship;Mexican;Mexico;Mutation;mutation carrier;Neurodegenerative Disorders;Neurologic;Neuropsychology;Onset of illness;Pathogenicity;Patient Care;Performance;Persons;Phase;Phenotype;Population;Populations at Risk;presenilin-1;presenilin-2;presymptomatic testing;Prevention;Procedures;prospective;Protocols documentation;PrP gene;Reporting;Research;research clinical testing;Research Infrastructure;Research Personnel;research study;Resources;Risk;Spastic Paraparesis;Standardization;standardize measure;System;Technology;Testing;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Phenotype and Genotype of Autosomal Dominant Alzheimer's Disease in Jalisco, Mexico


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Studies proposed here are designed to elucidate the contribution of the alteration of cellular organelles, specifically lysosomes and their communication with mitochondria, in blood forming stem and progenitor cell progression towards producing leukemic stem cells. These studies are devised to uncover targetable metabolic mechanisms that promote therapy-resistance in leukemias.

PI_NAMEs: GHAFFARI, SAGHI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adopted;Adult;Aging;Autophagocytosis;Biology;Blood;Cell Maintenance;Cell Separation;Cells;Cellular Metabolic Process;Clinical;Clonality;Communication;design;Disease Progression;Fostering;Functional disorder;Gene Modified;Gene Targeting;Generations;Genomics;Glucose;Glycolysis;Goals;hematopoietic stem cell quiescence;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Heterogeneity;high resolution imaging;Human;Image;Imaging Techniques;improved;in vivo;leukemia;leukemia treatment;leukemic stem cell;leukemic transformation;Link;Lysosomes;Maintenance;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;molecular dynamics;mouse model;Mus;Myeloid Leukemia;Myeloproliferative disease;Nutrient;Organelles;Outcome;Pathogenesis;Patients;Population Heterogeneity;Preleukemia;preservation;Process;Property;Recurrence;Recycling;Regulation;Relapse;Repression;Resistance;Sampling;stem;stem cell division;stem cell population;stem cells;Testing;therapeutic target;therapy design;therapy outcome;Time;Treatment Failure;Work

PROJECT_TITLE: Lysosomes and their Communications with Mitochondria in Leukemic Stem Cell Disease Progression

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN MARCOS

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: PROJECT NARRATIVE The education, mentoring, and training of underrepresented groups for professional research careers in the biomedical sciences through the North County San Diego Bridges to the Baccalaureate Program will serve to advance the goal of NIGMS to increase diversity in the scientific workforce. The Bridges initiative is designed to assist Bridges Scholars in transferring to a four-year institution, completing their B.S. degrees, and eventually obtaining careers in the biomedical sciences. These underrepresented community members are not represented in the professional research workforce of the nation and consequently we lose a significant talent that can make meaningful contributions to the health and quality of life of the country.

PI_NAMEs: BROWN, TRACEY K (contact);GARCIA, DENISE ;MORGADO FLORES, PEDRO ;PEARSON, ELIZABETH

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic skills;Academic support;Bachelor's Degree;Biomedical Research;bridge program;bridge to the baccalaureate;California;career;career awareness;career development;college;community college;County;Credentialing;Degree program;design;Development;Development Plans;Doctor of Medicine;Doctor of Philosophy;Dropout;Education;Educational Curriculum;Educational workshop;empowerment;Enrollment;Ensure;experience;Exposure to;faculty research;Fostering;Goals;Individual;Institution;Mentors;National Institute of General Medical Sciences;pedagogy;peer;peer coaching;Program Development;programs;Recording of previous events;Recruitment Activity;Reproducibility;Research;Schools;Science;skills;social;Structure;Students;summer research;supplemental instruction;symposium;Training;Training Programs;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;university student

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Acute myeloid leukemia (AML) is the most lethal hematological malignancy, and alternatives to chemotherapy such as differentiation therapy are greatly needed. We recently found that the H3K9 histone acetyltransferase KAT6A cooperates with the H3K9ac reader protein ENL to promote stemness and proliferation in AML. Here, we aim to determine the molecular mechanisms by which KAT6A and ENL cooperate to drive leukemogenic gene expression programs, and to identify the genetic subtypes of AML that are most sensitive to KAT6A inhibition.

PI_NAMEs: BLANCO, MARIO ANDRES (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Binding;Biochemical;Biological Assay;burden of illness;Cell Cycle;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;chemotherapy;Chimeric Proteins;ChIP-seq;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR screen;Data;design;Differentiation Therapy;Disease;Disease Progression;Disease remission;DNMT3a;ENL Protein;Epigenetic Process;epigenome;epigenomics;FLT3 gene;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Hematologic Neoplasms;Hematopoiesis;histone acetyltransferase;histone-binding proteins;Human;Impairment;In Vitro;in vivo;Individual;inhibitor;KDM1A gene;Knock-out;Mass Spectrum Analysis;Methodology;Methods;Methylcellulose;MLL-AF9;MLL-rearranged leukemia;Modeling;Molecular;mouse model;Mus;mutant;Myelogenous;novel;Oncogenes;Patients;Pharmaceutical Preparations;Play;programs;Progranulocytes;Proliferating;promoter;protein complex;Reader;recruit;response;Role;Sampling;Scheme;self-renewal;small molecule;stemness;success;synergism;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Toxic effect;transcription factor;transcriptome;transcriptome sequencing;transplant model;treatment effect;Work;Xenograft Model

PROJECT_TITLE: Investigating the role of KAT6A in MLL-rearranged acute myeloid leukemia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This application for an Outstanding Investigator Award builds on a long history of discoveries concerning the p53 tumor suppressor protein and its negative regulators Mdm2 and MdmX in the laboratory of the Principle Investigator. The research planned will identify new ways to strengthen the roles of p53 in protecting from cancer and to prevent Mdm2 and MdmX from promoting oncogenesis. Such findings may eventually yield new diagnostic and therapeutic tools for treating cancer patients.

PI_NAMEs: PRIVES, CAROL  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Animals;anti-tumor agent;Award;Binding;Biological Markers;cancer cell;Cancer Patient;Cell Cycle Arrest;Cell Death;Cell Line;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Cytostatics;cytotoxic;Diagnosis;Diagnostic;DNA Repair;DNA Sequence;Genes;Genetic Transcription;genotoxicity;Goals;Homologous Gene;Human;In Vitro;in vivo;Inherited;Laboratories;Lead;Li-Fraumeni Syndrome;Malignant Neoplasms;Mediating;Metabolic;mutant;Mutation;new technology;Normal Cell;novel;novel diagnostics;novel strategies;novel therapeutics;Oncogenic;Outcome;Peptides;Pharmaceutical Preparations;Play;prevent;Process;programs;Proteins;Reagent;Recording of previous events;Research;Research Personnel;Resolution;Role;senescence;Series;single molecule;Site;small molecule;Stimulus;Stress;Therapeutic;Therapeutic Agents;therapeutically effective;Tissues;tool;TP53 gene;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Functions and Activities of p53 and Mdm2 in Normal and Cancer Cells


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Auditory verbal hallucinations (AVH) are major causes of distress and disability in psychosis. Emerging evidence suggests that some people who experience AVH are capable of developing voluntary control over their onset and offset, but very little is known about the mechanisms underlying this ability. We propose a coordinated approach to understanding voluntary control over AVH, with the goal of generating knowledge capable of rapid translation into new treatments based on enhancing control over AVH.

PI_NAMEs: POWERS, ALBERT R (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TITLE: Neural Mechanisms of Voluntary Control Over Hallucinations

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SAGE BIONETWORKS

ORG_STATE: WA

PHR: Project Narrative Understanding the factors that contribute to exceptional long life represents an opportunity to discover how to extend healthy aging and protect from diseases of old age. This proposal describes the development of a Data Coordination and Management Core (DMCC) designed to bring together researchers and resources from across the field of longevity research to further our understanding of exceptional long life.

PI_NAMEs: FABRE SUVER, CHRISTINE M.;SIEBERTS, SOLVEIG ;VARMA, SUSHEEL  (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Acceleration;Address;age-related disease;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Benchmarking;Biological;burden of illness;Catalogs;Cognitive;Collection;Communities;Complex;Data;Data Commons;Data Coordinating Center;data ecosystem;data harmonization;data integration;data management;data sharing;data standards;Dementia;design;Development;Disease;Elderly;Environment;Evaluation;Evaluation Research;experience;FAIR principles;Funding;Genetic;genomic locus;Goals;Health;healthy aging;Human;human old age (65+);improved;Individual;Infrastructure;Institution;Interdisciplinary Study;interoperability;Knowledge;Knowledge Portal;Lead;Life;life span;Longevity;Medicine;Meta-Analysis;Metabolism;Methods;Mission;Molecular;Molecular Profiling;multiple omics;National Institute on Aging;open data;Outcomes Research;Physiological;programs;protective factors;Quality of life;Research;Research Design;Research Personnel;Research Project Grants;resilience;Resource Sharing;Resources;Risk Factors;Science;Structure;Synapses;Systems Biology;tool;Training;Work;working group

PROJECT_TITLE: Exceptional Longevity Data Management and Coordinating Center