ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Kidney Disease

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The accumulation of fat inside of podocytes, which are key cells of the kidney filter, is an important event that contributes to progression of kidney disease. With this application, we propose to investigate how deficiency of a protein named Apolipoprotein M (APOM) affects fat content and utilization in podocytes, contributes to the leakage of protein into the urine and we aim at understanding if patients with deficiency of APOM are at higher risk for the progression of kidney disease. The strength of this proposal lies in the innovative idea on how this protein modulates fat content in the kidney, how it can be utilized to identify patients at risk, and how replacement of the deficient protein can cure kidney disease in experimental models

PI_NAMEs: FORNONI, ALESSIA  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Affect;Albumins;antagonist;Apolipoproteins;Apoptosis;Binding;Biological Markers;Biology;Cell Survival;Cholesterol;Circulation;clinical application;clinical development;cohort;Complex;Cyclodextrins;Data;Devices;disease model;Disease Progression;Enrollment;Enzymes;Event;Exhibits;Experimental Models;Extravasation;Fatty acid glycerol esters;Gene Expression Profile;Genotype;Goals;Grant;Hereditary nephritis;High Density Lipoproteins;high risk;Human;Impairment;In Vitro;Injury;innovation;interest;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;lipidomics;Lipids;Lipoproteins;Liquid substance;Metabolic Diseases;Metabolism;migration;Molecular;Molecular Chaperones;mouse model;mRNA Expression;Mus;Mutation;Names;Nephrotic Syndrome;novel therapeutics;outcome prediction;overexpression;particle;Pathway interactions;Patients;Pattern;Phenotype;Physiological Processes;Plasma;podocyte;prevent;progression risk;Proliferating;Protein Deficiency;Proteins;Proteinuria;Proteomics;Recombinants;Renal glomerular disease;Research;reverse cholesterol transport;Risk;Role;Signal Transduction;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine-1-phosphate lyase;Sphingosine-1-Phosphate Receptor;SPHK1 enzyme;Therapeutic;Therapeutic Effect;translational approach;translational study;United States;Urine

PROJECT_TITLE: APOM deficiency contributes to renal failure in glomerular diseases

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: GALVESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Respiratory syncytial virus (RSV) is a leading cause of respiratory illness for which no effective therapeutic or licensed vaccine are available. The proposed study would provide critical new understanding to the function of hypoxia inducible factors to the pathogenesis of viral respiratory infections. This has the potential to strengthen drug development against RSV infections and reduce the burden on infants, young children, and the elderly alike.

PI_NAMEs: CASOLA, ANTONELLA  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 2019-nCoV;Acute;Acute Lung Injury;airway epithelium;airway remodeling;Anemia;Animal Cancer Model;Animal Model;Anti-viral Response;Antibody Formation;antiviral immunity;Autoimmunity;B-Lymphocytes;Cancer Model;cancer type;Cell Survival;Cells;Cellular Metabolic Process;Child;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;Collagen;Complex;cytokine;Cytokine Gene;Data;Dendritic Cells;Deposition;Development;Disease;drug development;Drug Modulation;Drug usage;Elderly;Epithelial Cells;Exhibits;experience;extracellular;factor A;Flow Cytometry;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Goals;high risk;Histopathology;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immune;immune activation;Immune response;immunoregulation;improved;In Vitro;in vivo Model;Inbred BALB C Mice;Infant;Infection;Inflammation;inhibitor;Interleukin-10;Investigation;Kinetics;Knowledge;Laboratories;Licensing;Lower Respiratory Tract Infection;Lung;Lung Diseases;Lung infections;lung injury;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;migration;Molecular;mouse model;Mucous body substance;Mus;neutrophil;novel;Outcome;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phase III Clinical Trials;Phenotype;Play;Population;Process;Production;Productivity;protective effect;Proteins;Publications;pulmonary function;Pulmonary Inflammation;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;response;Role;Shapes;side effect;Signal Transduction;Structure;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;tissue regeneration;Transcription Process;Transcriptional Regulation;Transforming Growth Factor beta;vaccine access;Vaccines;Viral;Viral Pathogenesis;Viral Respiratory Tract Infection;Virion;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Role of Hypoxia-Inducible Factors (HIFs) in Respiratory Syncytial Virus Infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: LIU, XIAOWEI SHERRY (contact)

PROJECT_TERMS: Acute;Aging;Animal Model;Animals;base;Biological Assay;Biological Process;bone;bone imaging;calcification;Cartilage;Chronic;clinical imaging;Clinical Research;Collaborations;Communities;Computer software;Consultations;contrast enhanced;Data;Data Analyses;density;Development;Disease;Doctor of Philosophy;E-learning;Education;Evaluation;Event;extracellular;Faculty;Fibrocartilages;Floor;Foundations;Freezing;Funding;Genetic;Glycosaminoglycans;Health;Histologic;Histological Techniques;Histology;Home;Human;human tissue;Image;imaging approach;imaging modality;Imaging Techniques;Immunohistochemistry;in vivo;injury and repair;innovation;insight;Intervertebral disc structure;Laboratories;Laboratory Animals;Location;Maintenance;Measurement;Mechanics;member;Methods;microCT;mineralization;Modality;Modeling;Morphology;Muscle;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal Physiology;Musculoskeletal System;novel;Paraffin;Pathologic;Pennsylvania;Peripheral;Philadelphia;Process;programs;protocol development;repaired;Research;Research Design;Research Personnel;Resolution;Resources;Roentgen Rays;service delivery;Services;Skeleton;soft tissue;Stains;Structure;Techniques;Tendon structure;three-dimensional visualization;Time;Tissue Engineering;Tissue Model;Tissue Sample;Tissues;tool;Training;University resources;X-Ray Computed Tomography

PROJECT_TITLE: Micro-CT Imaging Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Drug dependence and addiction continue to constitute a major health and economic burden and our inadequate understanding of the underlying neurobiology limits better diagnostics and interventions. The proposed studies will investigate the role of neuromedin s (NMS) neurons in the ventral tegmental area in morphine responses. These data will provide rationale for design of specific NMS pharmacological reagents, offering the promise that insights gained in these studies could lead to improved treatment of addiction, a high interest priority of NIDA.

PI_NAMEs: MAZEI-ROBISON, MICHELLE SUZANNE (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Adult;Affect;Afferent Neurons;Affinity Chromatography;Behavior;Behavioral;behavioral response;Biological Assay;cell type;Cells;Characteristics;Chronic;circadian regulation;Clozapine;Clustered Regularly Interspaced Short Palindromic Repeats;conditioned place preference;CRISPR/Cas technology;Data;Data Set;design;designer receptors exclusively activated by designer drugs;Diagnostic;Dopamine;dopaminergic neuron;Drug Addiction;drug reward;Drug usage;Economic Burden;Exhibits;Future;Gene Expression;Genes;Goals;Health;Hippocampus;Hormone Responsive;Hypothalamic Hormones;improved;insight;interest;Intervention;Intraperitoneal Injections;Knock-out;Mediating;Molecular;Morphine;motivated behavior;Mus;Names;National Institute of Drug Abuse;Neurobiology;neurochemistry;neuromedin U receptor;Neurons;Neuropeptides;neurotransmitter release;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Output;Oxides;Pharmaceutical Preparations;pharmacologic;Physiological;Population;Production;Property;Reagent;receptor;receptor expression;Reporting;response;reward circuitry;Rewards;Ribosomes;Role;sensory cortex;Site;Structure;suprachiasmatic nucleus;targeted treatment;Therapeutic Intervention;Tissues;transcriptome sequencing;Transgenic Mice;Translating;Ventral Tegmental Area;Viral Vector;Work

PROJECT_TITLE: Role for novel ventral tegmental area neuromedin S neurons in morphine responses

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative People with sensorineural hearing loss face the most difficulty understanding speech in noisy backgrounds, with significant individual differences in this ability across people with the same degree of clinically defined hearing loss. This study synergizes expertise in animal and human auditory neuroscience in a coordinated cross-species experimental design that will characterize the effects of sensory, neural, and synaptic dysfunction on modulation coding and perception of signals in noise. Data will be harmonized in an open-source data-science framework to facilitate short-term advances in our understanding of the relations between individual differences in peripheral pathophysiology and real-world listening, and long-term advances in personalized audiology to target treatment and counseling to individual patients, which will ultimately lead to better hearing health, quality of life, and lower healthcare costs.

PI_NAMEs: HEINZ, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: accurate diagnosis;Acoustic Nerve;Affect;Age;Anatomy;Animals;Audiology;Auditory;Categories;causal model;Chinchilla (genus);Clinical;clinical candidate;clinical database;clinical practice;Clinical stratification;Clinical Trials;Cochlea;cochlear synaptopathy;Code;Communication difficulty;Complex;cost;Counseling;Cues;Data;Data Science;Diagnostic;experience;Experimental Designs;Face;Family;Fiber;Functional disorder;Future;Health;Health Care Costs;Hearing;Hearing Aids;hearing impairment;Human;human data;Individual;Individual Differences;individual patient;individualized medicine;Joints;Knowledge;Link;Measures;Mental Health;Modeling;Nerve Fibers;neural;Neurosciences;Noise;noise perception;noninvasive diagnosis;novel;open data;Outer Hair Cells;Perception;Performance;Peripheral;Persons;Physiological;pre-clinical;Psychometrics;Psychophysics;Publishing;Quality of life;recruit;response;segregation;Sensorineural Hearing Loss;Sensory;Signal Transduction;social;sound;Source;Speech;speech in noise;Speech Perception;speech recognition;Stimulus;Synapses;synergism;Technology;Testing;Translations;Work

PROJECT_TITLE: Effects of Sensorineural Hearing Loss on Robust Speech Coding

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Many medical device infections are caused by Staphylococcus aureus (S. aureus), which are debilitating due to their chronicity and antibiotic tolerance. We will explore the possibility that rewiring the metabolism of granulocytic myeloid-derived suppressor cells, an immune population that is key in preventing biofilm clearance, will inhibit their immune suppressive effects and decrease S. aureus burden. A better understanding of how metabolism controls immune cell function will guide the development of future strategies for the treatment of S. aureus biofilm infections.

PI_NAMEs: KIELIAN, TAMMY L (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Adoptive Transfer;aerobic glycolysis;Anti-Inflammatory Agents;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antiinflammatory Effect;Attenuated;bactericide;Cardiac Myocytes;Cell Physiology;cell type;Cells;Cellular Metabolic Process;chemotherapy;Chronic;Coculture Techniques;congenic;Data;Development;disability;Dyes;Endothelial Cells;Epithelial Cells;Excision;Exhibits;Exposure to;Extravasation;Future;Glycolysis;Glycolysis Inhibition;Goals;granulocyte;Health Care Costs;Human;humanized mouse;Immune;Immune Evasion;Immunosuppression;Impaired cognition;Implant;improved;In Vitro;in vivo;Infection;Infiltration;Inflammatory;Inflammatory Response;innovation;Label;Laboratories;Leukocytes;Link;Macrophage;Mediating;Medical Device;Mesenchymal Stem Cells;Metabolic;Metabolic Pathway;Metabolism;Microbial Biofilms;Mitochondria;Modeling;monocyte;mouse model;Movement;Mus;Myeloid-derived suppressor cells;Myocardial Ischemia;Nanotubes;neutrophil;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Oxidative Phosphorylation;Parkinson Disease;Pathologic;Pathology;Periprosthetic joint infection;Population;prevent;programs;Property;Prosthesis;PTPRC gene;Reporting;Role;Shapes;Site;Source;Spinal cord injury;Staphylococcus aureus;superresolution microscopy;T-Cell Activation;Tissues;treatment strategy;Work

PROJECT_TITLE: Modulating granulocytic myeloid-derived suppressor cell (G-MDSC) metabolic activity to promote Staphylococcus aureus biofilm clearance

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Depression;Mental Health;Neurosciences;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Androgen deprivation therapy (ADT) for prostate cancer induces cognitive impairment that negatively impacts the quality of life for prostate cancer survivors, for which there is currently no treatment. We will study the neural mechanisms underlying this cognitive impairment to identify potential treatment targets using a rat model of prostate cancer in which ADT is produced by chemical castration. We will then test the utility of novel therapeutic candidates for treating cognitive impairment after ADT without interfering with the anti-cancer efficacy of ADT. The overall goal is to improve the quality of life for prostate cancer survivors and their families.

PI_NAMEs: MORILAK, DAVID A (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: Address;Adverse effects;Affect;androgen deprivation therapy;Androgens;antagonist;anti-cancer;anti-depressive agents;Attention;Autoimmune;Brain;Brain Neoplasms;brain tissue;Cancer Patient;carcinogenesis;Castrate sensitive prostate cancer;Castration;Cells;Chemicals;Citalopram;Cognition;Cognitive;cognitive change;cognitive performance;dementia risk;drug candidate;Endocrine;enzalutamide;executive function;Family;Functional disorder;Goals;Growth;Hippocampus;Impaired cognition;Impairment;Implant;improved;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-6;Intervention;JAK2 gene;knock-down;Label;Location;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medial;Mediating;Mediator;Memory impairment;Mental Depression;Metabolic Brain Diseases;Metastatic malignant neoplasm to brain;Modeling;Monitor;neural;neural circuit;neuroimaging;neuroinflammation;neuromechanism;neuronal circuitry;Neurons;Neurophysiology - biologic function;Neuroprotective Agents;neurovascular;Nicotinamide adenine dinucleotide;novel;novel therapeutic intervention;novel therapeutics;Ondansetron;Oxidative Stress;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical therapy;Prefrontal Cortex;prevent;Process;prostate cancer cell;prostate cancer model;prostate cancer survivors;Prostate Cancer therapy;Prostatic Neoplasms;Quality of life;Rattus;receptor;Reporting;Research;response;reuptake;Role;Selective Serotonin Reuptake Inhibitor;Serotonin Receptors 5-HT-3;Signal Transduction;Sprague-Dawley Rats;Structure;Survivors;Testing;therapeutic candidate;Therapeutic Effect;therapeutic evaluation;therapeutic target;Time;Translations;tumor progression;Visuospatial;Work

PROJECT_TITLE: Therapy-induced cognitive impairment in a rat model of prostate cancer


NIH_SPENDING_CATS: Genetics;Hearing Loss;Human Genome;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narratives: Hearing loss is the most frequent sensory defect in humans and about one in 1,000 children is affected by severe deafness at birth or during early childhood. This grant proposes to systematically elucidate how a small group of progenitor cells are induced to become functional sensory neurons and hair cells in the inner ear. Identifying enhancers that mediate the activity of transcription factors and chromatin regulators to instruct sensory or neuronal-cell specific gene expression program should provide valuable insights into the genetic and epigenetic networks that underlie congenital neurosensory deficits.

PI_NAMEs: XU, PIN-XIAN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Afferent Neurons;Apical;ATAC-seq;base;Binding;Birth;Cell Cycle;Cell Differentiation process;Cell Lineage;cell regeneration;Cells;Child;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Cochlea;cochlear development;Complex;Coupled;cyclin-dependent kinase inhibitor 1B;Data;deafness;Defect;Development;Distal;early childhood;Ectoderm;Ectoderm Cell;Embryo;Enhancers;Epigenetic Process;Epithelial Cells;Epithelium;Gene Expression;gene interaction;Genetic;Genetic Transcription;genome resource;Goals;Grant;Hair Cells;Hearing;hearing impairment;hearing restoration;Histones;Human;Human Pathology;insight;Labyrinth;Mass Spectrum Analysis;Mediating;Molecular;Natural regeneration;Neurons;neurosensory;Nucleosomes;Otic Placodes;otoconia;Pattern;Phosphoric Monoester Hydrolases;Play;precursor cell;prevent;Principal Investigator;progenitor;programs;protein complex;Proteins;Regulation;Research;response;Role;Sensory;Sensory Hair;single-cell RNA sequencing;Site;Specific qualifier value;Specificity;stem cell proliferation;stem cells;Structure;Testing;Time;Transcription Coactivator;transcription factor

PROJECT_TITLE: Transcriptional networks establishing the precise gene expression states that define neurosensory cell identity in the inner ear

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF-R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Sexual violence (SV) is common among individuals with opioid use disorder (OUD) and confers risk for worse OUD-related clinical outcomes. Shame is a potential mechanism that may explain worse outcomes among individuals with OUD who have a history of SV, and the current study seeks to identify associations between event-level shame and short-term clinical outcomes (substance use, cravings, medication adherence, motivation, and self-efficacy for changing substance use) as well as associations between aggregate levels of shame and long-term clinical outcomes (treatment dropout, percentage of treatment appointments missed) among individuals in OUD treatment who report a history of SV. Improving our understanding of these associations will aid in the development of interventions to improve clinical outcomes among this high-risk population.

PI_NAMEs: BHUPTANI, PRACHI  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Address;Appointment;Area;avoidance behavior;career;Clinical;clinically relevant;cognitive interview;comorbidity;coping;craving;Cues;Development;Diagnostic Factor;Distress;Dropout;Early treatment;Ecological momentary assessment;Emotional;Event;experience;Feeling;follow up assessment;follow-up;Goals;High Prevalence;high risk population;improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;Literature;Measurement;Measures;medication compliance;men;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;Nature;Negative Reinforcements;novel;opioid use disorder;Outcome;Participant;Personal Satisfaction;Persons;Phase;Positioning Attribute;premature;programs;Protocols documentation;psychological distress;Public Health;Recording of previous events;Recovery;Reporting;Research;Research Personnel;response;Risk;Role;Sampling;Scientist;Self Efficacy;sexual role;sexual violence;Shame;skill acquisition;skills;social stigma;Social support;Stressful Event;substance use;substance use treatment;Surveys;Survivors;therapy development;Time;Training;Translating;Trauma;Treatment outcome;Woman;Work

PROJECT_TITLE: Shame among Sexual Violence Survivors in Opioid Use Disorder Treatment: Event-level and longitudinal effects on Cravings, Substance Use, and Treatment Engagement

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Public Health Relevance The Carolina Center for Population Aging and Health will support a productive group of scholars as they increase the pace and focus of their research on topics related to the demography and economics of aging. Faculty will conduct research and primary data collection in support of three themes: aging in diverse contexts, links between social and economic productivity and health, and measurement and methods. Research produced as part of this center will provide important new results on patterns and determinants of healthy aging around the world.

PI_NAMEs: FRANKENBERG, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Age;Aging;aging demography;aging population;aging related;Area;Biological Markers;Budgets;built environment;China;Cognition;cohesion;Collaborations;Critical Thinking;Data;Data Analyses;Data Collection;data dissemination;data enclave;data harmonization;data resource;Data Set;Demography;design;Development;Economics;Ecosystem;Ensure;Environment;Ethnic Origin;experimental study;Exposure to;Faculty;Family;Fostering;Funding;Gender;Genetic;Grant;Health;health disparity;Health Sciences;healthy aging;Home;Immigrant;Impact evaluation;India;Indonesia;Infrastructure;innovation;Intervention;Life Cycle Stages;Link;Longitudinal Surveys;Malawi;Measurement;Measures;Methods;mid-career faculty;middle age;Older Population;organizational structure;Pattern;Personal Satisfaction;Persons;Philippines;Pilot Projects;Policies;Population;population based;population health;Population Research;Postdoctoral Fellow;Process;Production;Productivity;Progress Reports;public health relevance;Race;Research;Research Personnel;Research Support;Resources;Running;Russia;Science;secondary analysis;Secure;sex;Shapes;skills;social;Social Sciences;Societies;Socioeconomic Status;Source;Sri Lanka;stressor;Students;Subgroup;Surveys;Talents;Testing;tool;United States;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Genetics;Kidney Disease;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Genetic mutations of kidneys causing salt wasting can lead to electrolyte disturbances, cardiac arrhythmia, and progression to chronic kidney disease. The project will reveal insights into the disease mechanism of one group of genetic salt-wasting kidney diseases and may provide a potential therapeutic strategy for treating the disease.

PI_NAMEs: CHENG, CHIH-JEN  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: absorption;Affect;Agonist;antenatal;Apical;apical membrane;Apoptotic;Arrhythmia;Bartter Disease;Bioenergetics;Biogenesis;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell Proliferation;cell type;Cells;Cellular Assay;Chloride Channels;Chlorides;Chronic Kidney Failure;Coupled;Data;Defect;Development;Disease;Distal convoluted renal tubule structure;Disuse Atrophy;Diuretics;DNA Sequence Alteration;Electrolytes;Embryo;emerging adult;Equilibrium;Erythroid;Furosemide;G1 Phase;G1/S Transition;gain of function;Gene Deletion;Genetic;Genotype;Growth;Heterogeneity;Human;Hypertrophy;Impairment;In Vitro;in vivo;Inherited;insight;Ions;KCNJ1 gene;Kidney;Kidney Diseases;kidney medulla;Knock-out;Light;Link;loss of function;Microscopy;Mitochondria;mitochondrial dysfunction;Morphology;mouse model;Mus;mutant;Mutation;Nuclear;Orthologous Gene;Outcome;overexpression;Oxidative Phosphorylation;Pathogenesis;Patients;Peroxisome Proliferator-Activated Receptors;Phenotype;Proliferating;Regulation;Renal tubule structure;Reporting;restoration;Role;Side;Sodium Chloride;Structure of ascending limb of Henle's loop;Testing;Therapeutic;thiazide;Thick;Three-Dimensional Imaging;transcription factor;transcriptome;Transgenes;Tubular formation;Type II Pseudohypoaldosteronism;wasting

PROJECT_TITLE: Exploring the pathogenesis of classic Bartter syndrome

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Adolescent;Adult;Advisory Committees;Aging;aging population;aging related;Area;Biological Markers;Budgets;China;Collaborations;Communities;Creativeness;Critical Thinking;Data;Data Collection;data harmonization;Data Set;design;Ecological Change;Ecosystem;Educational workshop;Ensure;Environment;experience;experimental study;Faculty;Fostering;Genetic;Goals;Health;healthy aging;Home;Indonesia;innovation;interest;intergenerational;Interview;Leadership;Light;Longitudinal Studies;Malawi;Measures;meetings;Methods;middle age;Monitor;National Longitudinal Survey of Adolescent to Adult Health;Older Population;operation;Outcome;Paper;Parents;Philippines;Pilot Projects;Policies;Population;population health;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Progress Reports;Public Domains;Publications;Research;Research Personnel;Research Support;Resources;Respondent;Science;Services;Shapes;Structure;Students;success;Surveys;Talents;Technology;Time;wearable device;Work

PROJECT_TITLE: Carolina Center on Population Aging and Health:  Administrative Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Social Determinants of Health

PI_NAMEs: AIELLO, ALLISON E (contact)

PROJECT_TERMS: Address;Aging;aging population;Applications Grants;Award;built environment;Cognition;Collaborations;Data;Data Analyses;Data Collection;data resource;Demography;design;Development;Disparity;Economics;Evolution;experience;Exposure to;Faculty;Feedback;forging;Fostering;Funding;Future;Generations;Goals;Grant;Health;healthy aging;Infrastructure;innovation;Life Cycle Stages;Life Experience;Link;Measurement;member;Mentors;Mentorship;Methodology;Methods;multiple data sources;notch protein;Outcome;Pilot Projects;population health;Poverty;Production;Productivity;Program Development;programs;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;Rotation;Science;Scientist;senior faculty;Shock;social;social disparities;Structure;Students;Techniques;Testing;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Carolina Center on Population Aging and Health:  Pilot Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE Hospital infections must be diagnosed and treated rapidly to minimize spread and maximize patient outcome. This proposal will deliver a novel infectious disease diagnostic that will arm clinicians with vital quantitative information across many candidate pathogens, allowing them to diagnose and treat infections more quickly and accurately.

PI_NAMEs: ABATE, ADAM R. (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;arm;Bacterial Infections;Biological Assay;Capillary Electrophoresis;Central Nervous System Bacterial Infections;Central Nervous System Infections;Clinic;Clinical;clinical diagnostics;Communicable Diseases;Complex;Concentration measurement;cost;Custom;Cytomegalovirus;Detection;Diagnosis;Diagnostic;Dideoxy Chain Termination DNA Sequencing;digital;disease diagnostic;Emulsions;Equipment;Family;FDA approved;Flaviviridae;Flavivirus Infections;gastrointestinal infection;Generations;Health;Hepatitis C;HIV;Hospitals;human genome sequencing;Human Resources;Individual;Infection;innovation;instrument;Investments;Laboratories;Length;Licensing;Liquid substance;Manuals;Measurement;Measures;Meningitis;Methods;Microfluidics;Minor;Molecular;multiplex assay;multiplex detection;Nature;next generation;Nosocomial Infections;novel;nucleic acid quantitation;Nucleic Acids;Nucleotides;Organism;pathogen;Patient-Focused Outcomes;Patients;Persons;Preparation;Procedures;Protocols documentation;ratiometric;Reaction;Reporting;Reproducibility;Resolution;respiratory;Respiratory Tract Infections;respiratory virus;Robotics;Running;Sampling;self assembly;Sepsis;Shipping;skills;Source;Specialist;Symptoms;Techniques;Technology;technology validation;Testing;Time;treatment response;Tube;Variant;Virus Diseases;Vision;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Next Generation Infectious Disease Diagnostics: Microfluidic-Free Gigapixel PCR with Self-Assembled Partitioning

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Hypertension;Kidney Disease;Pediatric

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Adult hypertension is common, is a leading cause of death, and originates in childhood; pediatric hypertension is increasingly common, causes heart and kidney injury, and predicts hypertension in later adulthood. Poor treatment response occurs in half of children, increasing the risk of heart and kidney injury; the reasons behind this are not well known, limiting patient care of this important disease. The goal of this K23 Mentored Career Development Award is to obtain further training and initiate a mentored research project to establish a foundation of clinical evidence of angiotensin-(1-7) in pediatric hypertension and related injury to the heart and kidneys by identifying differences in disease progression and treatment response and informing causal mechanisms with ultimate goals to i) define novel causes of disease; ii) inform a targeted treatment strategy; and iii) inform development of novel therapies.

PI_NAMEs: SOUTH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Adult;Age;aged;Albuminuria;Aldosterone;angiotensin I (1-7);Angiotensin-Converting Enzyme Inhibitors;Animal Model;anti aging;Area;assay development;Basic Science;Biochemical;Biological Assay;Biological Markers;Blood;Blood Pressure;blood pressure elevation;blood pressure reduction;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular system;career;career development;Cause of Death;Cells;Child;Childhood;Clinic;Clinical;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Coupled;Data;decubitus ulcer;Development;Development Plans;Disease;Disease Progression;Education;Equipment;Etiology;Excretory function;experience;experimental study;follow-up;Foundations;Funding;Future;Goals;Grant;Health;Heart;heart damage;Heart Injuries;Human Resources;Hypertension;Impairment;improved;improved outcome;Injury;Injury to Kidney;Institution;K-Series Research Career Programs;Kidney;Kidney Failure;klotho protein;Knowledge;Learning;Left Ventricular Hypertrophy;Life;life span;Lisinopril;Longitudinal cohort study;Measures;Mediating;Mediation;Mediator;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;normotensive;novel;novel therapeutic intervention;novel therapeutics;organ injury;Outcome;Oxidative Stress;Patient Care;patient oriented;patient oriented research;Patients;Pediatric cohort;Pharmaceutical Preparations;Phenotype;Plasma;Positioning Attribute;Prediction of Response to Therapy;Prevalence;prevent;professor;Prospective, cohort study;Public Health;Race;recruit;renal damage;Renin;Renin-Angiotensin System;Research;research and development;Research Project Grants;Research Training;Resources;response;Risk;Role;sex;skill acquisition;statistics;targeted treatment;tenure track;Time;Training;treatment response;treatment strategy;Uric Acid;Urine

PROJECT_TITLE: The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damage

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Lung;Patient Safety;Pneumonia;Pneumonia and Influenza

ORG_CITY: DOWNERS GROVE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MIDWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative: The proposed research is relevant to public health because antibiotic resistant infections caused by Klebsiella aerogenes, Klebsiella oxytoca, Klebsiella pneumoniae, and P. aeruginosa were responsible for approximately $2 billion in attributable healthcare costs and over 12,000 deaths in 2017 alone. Nearly half of all patients who develop severe pneumonia caused by pathogens like these will experience antibiotic treatment failure and up to 30% will not survive. This proposal will advance the NIH mission to protect and improve patient health by addressing the urgent for new and effective treatment strategies that restore antibiotic activity against these serious pathogens.

PI_NAMEs: RHODES, NATHANIEL JAMES (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Affect;Alveolar;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Area Under Curve;beta-Lactams;biobank;Biological Assay;Bronchoalveolar Lavage Fluid;Cause of Death;Cefepime;Cessation of life;Classification;Clinical;clinical efficacy;Clinical Research;clinical risk;Clinical Treatment;combat;Critical Illness;Data;Death Rate;design;Development;Diagnostic;Disease;Dose;Drug Exposure;Drug Kinetics;drug resistant pathogen;effective therapy;Epithelium;experience;Failure;falls;Funding;genome sequencing;Goals;Health;Health Care Costs;high risk population;hospital analysis;improved;individual patient;Infection;Infrastructure;Intensive Care Units;Klebsiella aerogenes;Klebsiella oxytoca;Klebsiella pneumoniae;Knowledge;Liquid substance;Measures;Mechanical ventilation;Meropenem;Mission;Modeling;mortality;mortality risk;Nosocomial Infections;Nosocomial pneumonia;Organ;Outcome;participant enrollment;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phenotype;Piperacillin;Plasma;Pneumonia;pneumonia treatment;prospective;Pseudomonas aeruginosa;Public Health;Regimen;Research;Research Infrastructure;Resistance;response;Risk;Risk Factors;sample collection;Sampling;simulation;Site;Specimen;Statistical Models;success;System;Systems Biology;Time;tool;Treatment Failure;treatment optimization;treatment strategy;United States National Institutes of Health;Universities;Validation;whole genome

PROJECT_TITLE: Systems-based pharmacologic modelling to elucidate beta-lactam clinical pharmacodynamics and define optimal dosing regimens in severe pneumonia

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative The high rates of premature dropout in addiction treatment programs prevents clients with substance use disorders from receiving and fully benefiting from the wealth of evidence-based treatments available. While the assessment-based approach used during a client’s initial contact with a treatment program offers important information for regulatory agencies, gathering information rather than exploring client reasons for treatment may influence a client’s decision to return to treatment. This patient-oriented career development award will provide the candidate with mentorship and hands-on training in order to examine (1) the clinical utility of a stand-alone motivational interviewing intervention on client engagement, (2) the extent to which in-treatment factors explain engagement-related outcomes, and (3) feedback from treatment personnel on the feasibility, facilitating factors, and barriers to implementing MI at intake in addiction treatment programs.

PI_NAMEs: HURLOCKER, MARGO  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Alcohols;Ambulatory Care;Area;Attention;Award;Behavior Therapy;career development;Client;Clinical;Clinical effectiveness;Clinical Trials Design;Consolidated Framework for Implementation Research;cost;Data;Data Collection;design;Development;Dose;Dropout;Drops;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness/implementation design;effectiveness/implementation hybrid;Elements;Evidence based intervention;Evidence based treatment;experimental study;Feedback;Funding;Goals;Grant;health care delivery;Healthcare;Human Resources;implementation evaluation;implementation process;implementation science;implementation strategy;improved;Influentials;information gathering;innovation;Intake;Intervention;Interview;K-Series Research Career Programs;Literature;Measures;Mentors;Mentorship;Methods;Modeling;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;New Mexico;Outcome;Participant;patient engagement;patient oriented;patient oriented research;Patients;Prediction of Response to Therapy;premature;Preparation;prevent;Probability;Procedures;Process;Process Assessment;process evaluation;programs;Provider;Readiness;Recommendation;Reporting;Research;Research Personnel;research study;skills;Structure;substance use;Substance Use Disorder;System;Targeted Research;Testing;theories;Therapeutic;Time;Training;Treatment Factor;treatment program;Universities;Washington

PROJECT_TITLE: Adapting intake procedures to improve treatment delivery in addiction treatment

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Via a longitudinal study of brain development (from late childhood to early adolescence), this study seeks to find additional evidence supporting a hypothesis of overly rapid followed by too slow brain maturation in children with autism spectrum disorder (ASD); positive findings will suggest a basic mechanism that results in a patterned derailment of emerging neural processes in ASD that extends far beyond infancy and early childhood. In parallel, the study will map a shifting landscape of ASD auditory encoding and resting-state neural markers in order to identify late childhood and early adolescence diagnostic markers and treatment targets that are specific to age, brain location, and neural process. Finally, building upon the PIs adult studies, analysis of simultaneously collected magnetoencephalography (MEG) and high-density electroencephalography (EEG) will assess the consistency of MEG and EEG measures as well as the prospect of translating MEG and EEG brain source-space findings to much more clinically scalable scalp EEG.

PI_NAMEs: EDGAR, JAMES CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 8 year old;Acceleration;Adolescent;Adult;Age;age related;Alpha Rhythm;Anxiety;Attention;Attention deficit hyperactivity disorder;Auditory;Auditory area;autism spectrum disorder;autism symptoms;autistic children;Brain;brain abnormalities;Brain Diseases;Brain imaging;Child;Child Development;Childhood;Clinic;Clinical;Clinical assessments;Clinical Research;clinically significant;cognitive ability;cognitive process;Communication;Communication difficulty;comorbidity;density;design;Development;Developmental Process;Diagnosis;diagnostic biomarker;Disease;early adolescence;early childhood;Electroencephalography;Foundations;Future;Gene Expression Regulation;Goals;Hearing problem;infancy;Intention;Interneurons;Intervention;Language;Left;Location;Longitudinal Studies;Magnetoencephalography;Maps;Measures;Methods;neural;neural circuit;Pattern;Preventive;Process;Pyramidal Cells;rate of change;Reporting;Research;response;Rest;Sampling;Scalp structure;Sensory;Series;Source;Specificity;Structure;Time;Translating;Work

PROJECT_TITLE: A longitudinal study of brain development in children with autism

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Bacterial viruses, called phages, infect and kill bacteria and thus represent a potential alternative to antibiotics. However, bacteria are equipped with diverse immune systems that prevent phage replication. We have identified a phage family possessing the most potent immune evasion tactics discovered to date, and will characterize their molecular mechanisms to identify and develop better phage therapeutics.

PI_NAMEs: BONDY-DENOMY, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Alleles;Antibiotics;Back;Bacteria;Bacteriophages;Biological;Biology;Biotechnology;Cations;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cryo-electron tomography;Detection;DNA;DNA biosynthesis;DNA Restriction-Modification Enzymes;drug resistant pathogen;Engineering;Enzymes;Exclusion;Experimental Genetics;experimental study;Family;fascinate;fighting;Future;Genes;Genetic Screening;genetic selection;Genetic Transcription;Genome;Goals;human pathogen;Immune;Immune Evasion;Immune system;Immune Targeting;Immunity;In Vitro;Infection;inhibitor;innovation;Ion Channel;Lytic;Medicine;member;Microbe;Microscopy;Modeling;Modification;Molecular;Molecular Target;mutant;Mutation;next generation;novel;Nuclear Pore;nuclease;Organelles;pathogen;Pathway interactions;Planets;prevent;Production;programs;Property;Protein Import;protein purification;protein transport;Proteins;Proteomics;Pseudomonas aeruginosa;response;restriction enzyme;Role;scaffold;Structural Models;Structure;success;Superbug;System;Testing;Therapeutic;Virus;Work

PROJECT_TITLE: Investigating the mechanisms that make jumbophages impervious to bacterial immune systems

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Patient Safety;Prevention;Vaccine Related

ORG_CITY: BETHESDA

ORG_NAME: EXBAQ LLC

ORG_STATE: MD

PHR: New technologies are needed to prevent, hospital acquired infections, which are the 6th leading cause of death in the US. The purpose of this proposal is to establish proof of principle that a novel vaccine strategy can broadly prevent infections caused by the most dangerous and common bacterial and fungal pathogens found in hospitals.

PI_NAMEs: SPELLBERG, BRAD J (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acinetobacter baumannii;Adjuvant;Aluminum Hydroxide;Antibiotic Resistance;Antimicrobial Resistance;Bacteria;Biological Assay;Biotechnology;Businesses;Candida albicans;Carbapenem-resistant Acinetobacter;Cause of Death;Classification;Clinical Protocols;Clinical Trials;Competitive Bidding;Contracts;cost;Dangerousness;Data;Diabetes Mellitus;Dose;experience;FDA approved;Funding;fungus;Future;Glucans;Goals;healthcare-associated infections;Hospitals;Human;Immune;Immunity;Immunization;immunotoxicity;Immunotoxicology;In Vitro;Infection;Infection prevention;Inflammasome;Innate Immune System;Kidney Diseases;Klebsiella pneumoniae;Lead;Ligation;Lipid A;Macrophage;Mannans;manufacture;member;methicillin resistant Staphylococcus aureus;mouse model;Mucormycosis;Mus;new technology;Nosocomial Infections;novel strategies;novel vaccines;parenteral administration;particle;Particulate;pathogen;pathogenic bacteria;pathogenic fungus;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Phase II/III Trial;Phase III Clinical Trials;Phylogenetic Analysis;pre-clinical;pre-Investigational New Drug meeting;prevent;programs;Protocols documentation;Regimen;Rhizopus;Rivers;scale up;Scientist;Small Business Technology Transfer Research;Source;Sterility;TLR4 gene;Toxicology;trial planning;United States Dept. of Health and Human Services;uptake;Vaccination;vaccine development;vaccine strategy;vaccine trial;Vaccines;Vendor

PROJECT_TITLE: Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  This proposal will improve our understanding of methicillin-resistant Staphylococcus aureus (MRSA) and Candida auris, two antibiotic-resistant pathogens common to nursing homes that spread by colonizing the body and shedding profusely into the environment. This work in nursing homes will identify risk factors associated with MRSA and C. auris carriage, which predisposes individuals to infection. It will also evaluate whether common care activities result in contamination of nearby objects, which would suggest the need for post-activity cleaning in the rooms of MRSA and C. auris carriers.

PI_NAMEs: GUSSIN, GABRIELLE  (contact)

PROJECT_TERMS: Acute;Address;Adverse event;adverse outcome;Affect;American;Antibiotic Resistance;Antibiotics;attributable mortality;Bathing;Beds;Biometry;California;Candida auris;career;Caring;Case Mixes;Characteristics;Clinical;Clinical Research;Communicable Diseases;comorbidity;County;COVID-19 pandemic;Data;Devices;Disease Outbreaks;Doctor of Philosophy;drug resistant pathogen;Environment;Environmental Pollution;Epidemiology;epidemiology study;Fellowship;fungus;Goals;Head;Health care facility;Healthcare;high risk;Home Nursing Care;Hospitalization;Hospitals;improved;Incontinence;Individual;Infection;Infection prevention;infection risk;Intensive Care Units;Intervention;Investigation;Link;Long-Term Care;Measures;Mentors;methicillin resistant Staphylococcus aureus;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;multidisciplinary;neglect;novel;Nursing Homes;operation;Oranges;pathogen;pathogenic fungus;patient population;Patients;Performance;population health;Prevalence;Prevalence Study;prevent;Prevention;Prospective Studies;Public Health;Quality of Care;Research;Resources;response;Risk;Risk Factors;Sampling;screening;Site;skills;Sterile coverings;Surface;Systems Biology;Touch sensation;Training;transmission process;Universities;Virulent;Work;wound

PROJECT_TITLE: Endemic and Emerging Multidrug Resistant Organisms in Nursing Homes: A Neglected Clinical Setting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: ES

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE – OVERALL While the name is not familiar, N-nitrosamines are among the most mutagenic chemicals known to humankind, and they are not only present at hazardous waste sites, but they are also present in our water, food and drugs. In response to the needs of agencies that are responsible for management of N-nitrosamine-contaminated sites, and to the needs of impacted communities (including the Passamaquoddy Tribe), the MIT Superfund Research Program scientists and engineers will work together to create new technologies to sense contaminants in the environment and to reveal their health impacts. Research will lead to new knowledge and technologies that will guide effective cleanup, destroy hazardous chemicals in drinking water, and identify opportunities for interventions that prevent disease, efforts that will collectively have a significant and sustained positive impact on public health.

PI_NAMEs: ENGELWARD, BEVIN P. (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;adverse outcome;analytical method;analytical tool;Animal Model;animation;Biochemical;Biological;Biomedical Research;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;career;Cells;Cellular Phone;Chemicals;Chloramines;citizen science;Coal;Collaborations;Collection;Communication;Communities;community engagement;community partners;Data;Data Analyses;data management;data sharing;data streams;detection assay;detector;Development;Devices;Dimethylnitrosamine;Disease;disorder prevention;DNA Damage;DNA Sequence Alteration;Dose;drinking water;Education;Educational process of instructing;Engineering;Environment;Environmental Engineering technology;environmental justice;Environmental Science;Evaluation;experience;Exposure to;Family;Filtration;Food;Genetic Engineering;Global Warming;Goals;graduate student;Hazardous Chemicals;Hazardous Substances;Hazardous Waste Sites;Health;Human;improved;Induced Mutation;innovation;Intervention;Knowledge;Learning;Light;Machine Learning;Malignant Neoplasms;Mammalian Cell;Mass Fragmentography;mathematical analysis;Measures;Mediating;meetings;member;Methods;Microarray Analysis;Mission;mouse model;Multiomic Data;Municipalities;Mutagens;Mutation;N-nitrosodimethylamine;Names;Nanotechnology;National Institute of Environmental Health Sciences;new technology;Nitrosamines;Nitroso Compounds;novel;optical sensor;Passamaquoddy;Pathway interactions;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population Growth;Postdoctoral Fellow;predictive marker;prevent;Probability;Probiotics;programs;Public Health;Recipe;remediation;Research;Research Project Grants;Research Support;response;Risk;Risk Assessment;Role;Scientist;sensor;sensor technology;Serinus;Site;Source;Statistical Data Interpretation;Structure;Sum;Superfund;superfund chemical;superfund site;synergism;System;Systems Biology;Technology;Testing;Toxic effect;Training;training opportunity;transcriptome;translational potential;Translational Research;Translations;Tribes;United States Environmental Protection Agency;wasting;Water;water sampling;well water;Work

PROJECT_TITLE: The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Significant variation currently exists amongst hospitals regarding NICU admission rates and clinical thresholds for admission in late preterm infants that is not explained by clinical illness. This suggests potential overutilization of NICU care, which may lead to unnecessary separation of the mother-infant dyad. The proposed research develop a prediction model identifying which late preterm infants are most likely to benefit from automatic admission to a NICU at the time of birth, safely minimizing mother-infant dyad separation and its associated implications.

PI_NAMEs: JOSHI, NEHA SHIRISH (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 37 weeks gestation;Address;Admission activity;Birth;Birth Weight;Breast Feeding;career;Career Choice;Career Mobility;Caring;classification trees;Clinical;clinical decision-making;cohort;cost;Data;Data Analyses;Data Set;Eligibility Determination;Environment;Evaluation;Event;evidence base;extreme prematurity;Fellowship;Frequencies;Gestational Age;Goals;Grant;Healthcare Systems;high risk;Hospitalization;Hospitals;Hyperbilirubinemia;Hypoglycemia;Incidence;Infant;Infant Care;infection risk;Institution;Intervention;K-Series Research Career Programs;lens;Life;Literature;Live Birth;Location;Medical;Methodology;Methods;Modeling;Morbidity - disease rate;Mothers;Neonatal Intensive Care Units;neonatal morbidity;Newborn Infant;Nurseries;Outcome;Patients;Pediatric Hospitals;Physicians;predictive modeling;Pregnancy;Premature Infant;Protocols documentation;regression trees;Reporting;Research;Research Design;Resources;Respiratory distress;Retrospective cohort;Risk;Scientist;Sensitivity and Specificity;Severity of illness;Site;skills;Stress;Symptoms;Techniques;Temperature;Testing;Time;Training;training data;United States;Universities;Validation;Variant;Writing

PROJECT_TITLE: Towards Identifying Optimal NICU Admission Criteria for Late Preterm Infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Complementary and Integrative Health;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – PROJECT 1 N-nitrosamines are probable human carcinogens that are present not only at Superfund Sites, but also in the municipal water that is used by the Passamaquoddy Tribe, making it imperative that the NIEHS Superfund Research Program enable problem-based solution-oriented research on N-nitrosamines using cutting edge technologies. Genetic engineering will be used to create `canary in a coal mine' mice that can be used to detect the potential danger of conditions that people are experiencing (e.g., long-term low-dose exposure in drinking water), and by using chemicals that make cells sensitive to N-nitrosamines, we will be better able to predict the health consequences of N-nitrosamines, and so be in a better position to develop ways to prevent disease. Technologies that will be developed and results from these studies will be shared with stakeholders, including other scientists, community members, and organizations that oversee cleanup and environmental policies (including the EPA) in order to maximize the impact of this work on public health.

PROJECT_TERMS: Address;Animals;animation;beneficial microorganism;Biological;Biology;Biosensor;carcinogenesis;Carcinogens;Cells;Chemical Engineering;chemical genetics;Chemicals;Coal;Collaborations;Communities;community engagement;Data;Data Analyses;data management;Development;Devices;Dimethylnitrosamine;Disease;DNA;DNA Adducts;DNA Damage;DNA glycosylase;DNA Repair;DNA Repair Disorder;DNA Sequence Alteration;Dose;drinking water;Educational Curriculum;Educational process of instructing;Ensure;Environment;Environmental Policy;experience;Exposure to;Food;gene environment interaction;Genetic Engineering;Genetically Engineered Mouse;Goals;Hazardous Chemicals;Health;health assessment;high throughput screening;Human;In Vitro;Induced Mutation;innovation;Intervention;Knowledge;Longitudinal Studies;Machine Learning;Malignant Neoplasms;mathematical model;Measures;member;Metabolic;Methods;Methyltransferase;Mission;Molecular;multiple omics;Municipalities;Mus;Mutagens;Mutation;Mutation Detection;N-Methylaspartate;N-nitrosodimethylamine;National Institute of Environmental Health Sciences;Nitrosamines;Nitroso Compounds;novel;Organism;Passamaquoddy;Persons;Pharmaceutical Preparations;Positioning Attribute;predictive marker;Predisposition;prevent;Probability;Probiotics;program dissemination;programs;Propylamines;Public Health;remediation;repaired;Research;Research Activity;Research Support;response;Risk;Scientist;screening;sensor;Serinus;Source;Structure;Superfund;superfund chemical;superfund site;System;Technology;Toxic effect;Training;Transgenes;Tribes;Water;Work

PROJECT_TITLE: Project 1: Assessment of the Health Effects of N-Nitrosamines and Development of Disease Mitigation Strategies


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Complementary and Integrative Health;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE – PROJECT 2 According to the World Health Organization, about one-quarter of human deaths are associated with environmental factors, dominated by air and water pollution. Genetic changes and cell signaling disruptions produced by such environmental chemicals underlie many of these disease outcomes. Given that carcinogenic chemicals were released from prior industrial activities at Superfund sites, this project uses a systems-based approach to examine the impact of these toxicants on the human genome and the repertoire of proteins that are involved in critical signaling systems.

PI_NAMEs: ESSIGMANN, JOHN M (contact)

PROJECT_TERMS: Acute;Address;Affect;Air Pollution;Animal Model;Animals;animation;Biological;Biological Markers;biological systems;burden of illness;carcinogenicity;Catchment Area;Cell Culture System;Cell Culture Techniques;Cell model;Cells;Cessation of life;Characteristics;Chemical Exposure;Chemicals;Collaborations;Communities;community engagement;community partners;Complex Mixtures;Custom;Data;Data Analyses;data management;Data Set;data streams;Detection;Dimethylnitrosamine;Disease;Disease Outcome;disorder prevention;DNA Adducts;DNA Damage;DNA Repair;DNA Repair Gene;DNA sequencing;Dose;drinking water;early onset;efficacy evaluation;Embryo;Environment;environmental chemical;Environmental Exposure;Environmental Risk Factor;Epidemiology;Etiology;Excision;Exposure to;Female;Fibroblasts;gene environment interaction;Gene Expression;Genetic;Genetic Engineering;Genetically Engineered Mouse;genome integrity;Genomics;genotoxicity;Goals;Hazardous Chemicals;Hazardous Substances;Health;high throughput screening;Human;human data;human disease;Human Genome;Individual;Industrialization;Inflammation;Informatics;insight;Intervention;Intraperitoneal Injections;Investigation;Kinetics;Knowledge;late life;Learning;Maine;male;Malignant Neoplasms;Mammalian Cell;Measurable;member;Methods;MGMT gene;Modeling;Molecular;Molecular Epidemiology;mouse model;multiple omics;Mus;Mutagens;Mutation;Mutation Spectra;N-nitrosodimethylamine;Nitrosamines;Nitroso Compounds;novel;overexpression;Passamaquoddy;Pathology;Pathway interactions;Pattern;Persons;Phenotype;phosphoproteomics;Phosphorylation;Predisposition;Prevention;Probiotics;Procedures;Process;programs;Propylamines;Protein Analysis;Proteins;Proteome;Proteomics;Public Health;Records;Regimen;remediation;Research;Resolution;response;Risk;Risk Assessment;Risk Reduction;Sampling;screening;Screening procedure;Signal Recognition Particle;Signal Transduction;Site;Source;stressor;Superfund;superfund chemical;superfund site;System;Techniques;Technology;Testing;The Cancer Genome Atlas;Tissues;tool;Toxic effect;Toxic Environmental Substances;toxicant;Toxicology;Toxin;transcriptomics;Tribal group;Tribes;tumor;Water;Water Pollution;welfare;Work;World Health Organization

PROJECT_TITLE: Project 2: High Resolution Mutation Spectra and Multi-Omics for Deducing Etiology and Predicting Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Psychosis;Rare Diseases;Schizophrenia;Serious Mental Illness;Sleep Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Chromosomal deletions at 22q11.2 are among the highest known genetic risk factors for the development of psychotic illness, while duplications at the same locus may be associated with decreased risk. Here we will prospectively study links between gene dosage effects, brain structure and function, sleep physiology and neurobehavioral outcomes in youth with 22q11.2 deletions and duplications, in order to advance our understanding of the mechanisms by which disruption of genes in this locus impacts brain development and ultimately contributes to disease pathogenesis.

PI_NAMEs: BEARDEN, CARRIE E (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 22q11.2;Acceleration;Adolescence;Adolescent;Age;Area;Automobile Driving;awake;Behavior;Bilateral;Biological;Biological Markers;Brain;brain abnormalities;Cell Cycle;Cell Nucleus;Cells;Chromosome Deletion;Chromosomes;Clinical;clinical high risk for psychosis;clinical phenotype;Cognition;cognitive development;cohort;Complex;Congenital Abnormality;Copy Number Polymorphism;Coupling;Data;design;Development;DiGeorge Syndrome;Disease;disorder risk;early detection biomarkers;Electroencephalography;emerging adult;ethnic diversity;Event;Evolution;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;gene conservation;Gene Dosage;Gene Expression;General Population;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genomic Segment;Genomics;Goals;Growth;Heterogeneity;high risk;Histology;imaging modality;Impaired cognition;Individual;Investigation;Language;Link;longitudinal design;longitudinal, prospective study;Methodology;Methods;microdeletion;Modeling;Mutation;neural;neural circuit;Neuroanatomy;neurobehavioral;Neurobehavioral Manifestations;neurodevelopment;Neurons;neuropsychiatric disorder;novel;Onset of illness;Outcome;Parietal;Pathogenesis;Patients;Pattern;Phenotype;Poverty;Pre-Clinical Model;Process;Proliferating;prospective;Prospective Studies;Psychoses;psychosis risk;psychotic;Psychotic Disorders;psychotic symptoms;Rest;Risk;Schizophrenia;Sleep;Sleep disturbances;sleep physiology;sleep spindle;Spanish;structural imaging;Structure;Surface;symptomatology;Symptoms;Testing;Thalamic structure;Thinness;virtual;Work;Youth

PROJECT_TITLE: Neurodevelopment and Psychosis in the 22q11.2 Copy Number Variants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-M(90)S]


NIH_SPENDING_CATS: Genetics;Human Genome;Osteoporosis

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Public Health Relevance Statement: While osteoporotic hip fracture rates had been decreasing, these serious and sometimes fatal fractures are again increasing in per capita incidence. One reason for this is that patients fear rare side effects caused by the available medications that are used to prevent the bone loss that can lead to fracture and are refusing treatment. The osteoblast is the cell that builds bone and this study is focused on identifying the regulators of osteoblast function, and potentially novel druggable targets that promote anabolic bone formation. The results of this project have the potential to lead to newer, more effective treatments for this common disease.

PI_NAMEs: ACKERT-BICKNELL, CHERYL LYNNE (contact);FARBER, CHARLES R

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;Age;Anabolic Agents;ATAC-seq;Bayesian Analysis;Bayesian Network;Black Box;bone;Bone Density;Bone Diseases;bone loss;bone mass;Bone Matrix;Bone remodeling;Bone Resorption;bone strength;Calvaria;candidate identification;causal variant;cell type;Cells;Child;Chromosome Mapping;Collaborations;common treatment;Complex;Complex Genetic Trait;Cytokinesis;Data;Development;Disease;Dissection;Drug Targeting;effective therapy;Equilibrium;Extracellular Matrix;FDA approved;follow-up;Fracture;fragility fracture;Fright;Genes;Genetic;genetic analysis;Genetic study;genome wide association study;genome-wide analysis;Goals;Heritability;Hip Fractures;Human Genetics;In Vitro;Incidence;insight;Maps;Measures;Mediating;migration;mineralization;Minerals;Mus;Mutant Strains Mice;neonate;Network-based;new therapeutic target;novel;osteoblast proliferation;Osteoblasts;Osteoclasts;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiologic calcification;Physiological Processes;Pilot Projects;Population;prevent;Prevention therapy;Process;Proliferating;public health relevance;Quantitative Trait Loci;Resolution;Risk;Role;side effect;single cell ATAC-seq;single-cell RNA sequencing;Site;Testing;Therapeutic;therapeutic target;Time;trait;translational potential;Trauma;Work

PROJECT_TITLE: Identification of Novel Genes Impacting Osteoblast Activity

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – PROJECT 3 N-nitrosamines are probably human carcinogens that are present not only at Superfund Sites, but also in the municipal water that is used by the Passamaquoddy Tribe, making it imperative that the NIEHS Superfund Research Program enable problem-based solution-oriented research on N-nitrosamines using cutting edge technologies. This project will provide improved methods for the detection of toxic N-nitrosamines in water and make the methods available to affected communities. Specifically, materials that absorb N-nitrosamines will be developed to improve detection, and easy-to-use field-deployable detection methods will be developed that exploit smartphone technology.

PI_NAMEs: SWAGER, TIMOTHY M (contact)

PROJECT_TERMS: absorption;Address;Affect;Animal Model;Binding;Biological;carcinogenicity;Carcinogens;Cellular Phone;Chemicals;citizen science;Collaborations;Color;Communities;community empowerment;community engagement;Comprehension;Data Analyses;data management;data streams;design;Detection;detection limit;detection method;detector;Devices;Dimethylnitrosamine;drinking water;Early Diagnosis;efficacy testing;Elements;Environment;environmental justice;experience;Film;Filtration;Food;Fostering;Goals;Halogens;Hazardous Chemicals;Health;Human;Hydrogen Bonding;improved;Individual;International Agency for Research on Cancer;Intervention;Knowledge;Laboratories;laboratory equipment;Liquid substance;Location;Measurement;member;Metals;Methods;Mission;Municipalities;Mutagens;N-nitrosodimethylamine;National Institute of Environmental Health Sciences;Nitrosamines;Nitroso Compounds;novel;optical sensor;Optics;organizational structure;particle;Passamaquoddy;Persons;Pharmaceutical Preparations;Phase;photolysis;Polymers;Porosity;Positioning Attribute;Prevention;Probability;Process;programs;Public Health;Reaction;Reader;Research;Research Support;Resistance;Risk;Seasons;sensor;Signal Transduction;Solid;Source;Superfund;superfund site;System;Technology;test strip;Testing;Training;Translating;Translational Research;Tribes;Ultraviolet Rays;Visual;Water;water sampling;Water Supply;water treatment;Weather

PROJECT_TITLE: Project 3: Methods for Selective Extraction, Concentration and Detection of N-Nitrosamines


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Overall Program Project Narrative  This project will advance understanding of diarrheal diseases caused by three important enteric pathogens, including two types of diarrheagenic E.coli and Shigella. A recently developed model of the human intestine called enteroids allows the formation of human mini-intestines that can mimic important aspects of disease due to these organisms and can be co-cultured with innate immune cells to more closely resemble normal intestine. Three universities with long histories of contributions in studying diarrheal diseases will collaborate in utilizing this novel model to study basic mechanisms of disease, characterize attenuated vaccine strains, and elucidate interactions with the immune system. Project Narrative Page 79

PI_NAMEs: FOULKE-ABEL, JENNIFER ;KAPER, JAMES B (contact);NATARO, JAMES P.

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;anti-microbial peptide;Attention;Attenuated Vaccines;Biological Response Modifiers;Cell Communication;Cell model;cell motility;Cell Physiology;Cells;Cellular biology;Childhood;Clinical;Coculture Techniques;Collaborations;Communicable Diseases;Culture Media;cytokine;Dendritic Cells;Development;Diarrhea;Diarrheagenic E. coli;diarrheal disease;Disease;Electronic Mail;Enteral;enteric pathogen;enteroaggregative Escherichia coli;enterotoxigenic Escherichia coli;Enterotoxins;Environment;Epithelium;Escherichia coli;eVisit;experience;Exposure to;Functional disorder;Funding;Gastroenterology;Glycoproteins;Goals;Goblet Cells;gut inflammation;Human;human model;Human Resources;Immune;Immune Evasion;Immune system;Immunology;improved;insight;International;Intestines;intraepithelial;Laboratories;Leukocytes;M cell;Macrophage;Maryland;Measurement;meetings;Methodology;Methods;Microbiology;Modeling;Molecular;monolayer;Mucins;Mucous Membrane;neutrophil;novel;Organism;pathogen;Pathogenesis;pathogenic bacteria;Peptide Hydrolases;Phagocytes;Physiology;Porosity;pre-clinical;Production;Program Research Project Grants;programs;Publications;Reagent;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Role;scaffold;Serine Protease;shear stress;Shigella;Shigella Infections;Shigella Vaccines;System;T-Lymphocyte;Telephone;tool;transcytosis;Universities;Virginia;Work

PROJECT_TITLE: Pathogenesis of E. coli and Shigella infections in human enteroid models


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Foodborne Illness;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – PROJECT 4 N-nitrosamines are probable human carcinogens that are present not only at Superfund Sites, but also in the municipal water that use used by the Passamaquoddy Tribe, making it important for this team to develop novel technologies for detecting N-nitrosamines in the environment and in people's tap water, as well as to create novel nanotechnologies and biotechnology approaches to destroy N-nitrosamines. The proposed studies will enable 1) agencies to understand the fate of this important class of compounds in the environment, 2) identification of contaminated water, and 3) deployment of under-sink devices that will protect people from these hazardous chemicals. Technologies that will be created and results from these studies will be shared with stakeholders at the local, state, tribal, and national levels (including the Environmental Protection Agency), in order to maximize the impact of this work on public health.

PI_NAMEs: PLATA, DESIREE  (contact)

PROJECT_TERMS: Acceleration;Address;Air;analytical method;animation;Biological;Biological Assay;Bioreactors;Biotechnology;Cancer Etiology;Carbon;Carbon Nanotubes;carcinogenesis;Carcinogens;Cells;Chemicals;Chromatography;Collaborations;Collection;community collaboration;community engagement;Complex Mixtures;contaminated water;Data;Data Analyses;data integration;data management;Detection;detector;Development;Devices;Dimensions;Disease;Disinfection;DNA Damage;drinking water;Encapsulated;Engineering;Ensure;Environment;Environment and Public Health;Environmental Exposure;Enzymes;Equilibrium;experience;exposed human population;Exposure to;Family;Filtration;Flame Ionization;Food;Gas Chromatography;Genetic Engineering;Genetically Engineered Mouse;genotoxicity;Goals;Hazardous Chemicals;Hazardous Substances;Health;Home;Human;improved;In Situ;invention;Ion Exchange;iterative design;Knowledge;Mass Spectrum Analysis;Measurement;Measures;Methods;Microbe;Mission;Modeling;Molecular;molecular recognition;Municipalities;Mutagens;Nanotechnology;new technology;Nitrosamines;Nitroso Compounds;novel;novel strategies;Octanols;Passamaquoddy;Performance;Persons;Pharmaceutical Preparations;Phase;Plant Resins;Polymers;Predisposition;prevent;Prevention;Probability;Process;programs;Property;Public Health;remediation;Research;Research Support;Risk;Safety;safety testing;scaffold;sensor;Solid;Source;spheroids;Structure;Superfund;superfund chemical;superfund site;System;Techniques;Technology;Testing;therapy design;toxicant;Training;Translational Research;treatment strategy;Tribes;United States Environmental Protection Agency;Water;water sampling;water treatment;Work

PROJECT_TITLE: Project 4: Measurement and Engineering Solutions to Detect and Prevent N-Nitrosamine Exposure


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

PI_NAMEs: KAPER, JAMES B (contact)

PROJECT_TERMS: Administrative Personnel;Administrator;Agreement;Annual Reports;Biological Models;Clinical;Communicable Diseases;Communication;Data;design;Disease;Ensure;Enteral;Escherichia coli;Financial Activity;flexibility;Gastroenterology;Gastrointestinal Physiology;Goals;Grant;Human;Immunology;Infrastructure;Interdisciplinary Study;Joints;Laboratories;Leadership;Maryland;medical schools;meetings;Microbiology;Modeling;Molecular;National Institute of Allergy and Infectious Disease;Office Management;Pathogenesis;Pediatrics;Program Research Project Grants;Program Reviews;programs;Progress Reports;Reporting;Research;Research Activity;Research Project Grants;Resources;Shigella Infections;Structure;symposium;synergism;System;United States National Institutes of Health;Universities;vaccinology;Virginia;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Both tau and amyloid-β peptide (Aβ) form unusual clumps in brains of Alzheimer's disease (AD) patients. While Aβ forms plaques extracellularly, tau has been thought to form tangles within the cytoplasm of neurons. However, increasing evidence shows that tau physiologically exists in the extracellular fluid. In fact, vascular deposition of oligomeric tau (o-tau) was observed in brains of AD patients and Tg2576 mice. In turn, o-tau has been reported to be the most toxic form of tau. These recent findings lead to a new hypothesis that vascular deposition of o-tau is involved in driving the vasculopathy in AD. To test this hypothesis, we examine the roles of NADPH oxidase, cytosolic phospholipase A2, and NFκB in the effects of o-tau on oxidative stress, inflammation, expressions of adhesion molecules, and membrane tether adhesion mechanics in human brain microvascular endothelial cells (HBMECs), and transmigration of THP-1 cells across the HBMEC layer. The retina, as a part of the brain, opens a window for high-resolution study of neurovascular defect. We also employ the non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) (i.e. OCT/OCTA) to study microvascular characteristics and neurodegeneration, as quantified by the ganglion layer thickness (GLT), and their relations to oligomeric Aβ (oAβ), and o-tau contents in retinas of Tg AD mouse models for studying the influences of human tau and amyloid pathology including APPswe/PSEN1dE9 and 3xTg AD mice. This project will fill the research gap between extracellular o-tau and neurovascular abnormalities in AD by providing information regarding adhesion mechanical responses to o-tau in HBMECs, and changes in retinal vessel network characteristics and GLT in relations to Aβ and o-tau, and ultimately provide insights into therapeutic strategies for AD treatment by regulating tau's effects.

PI_NAMEs: LEE, JAMES C (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3xTg-AD mouse;abeta oligomer;Actins;Adhesions;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease patient;Amyloid beta-Protein;amyloid pathology;Angiography;Atomic Force Microscopy;Automobile Driving;Biochemical;Biophotonics;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;Caliber;Cell Adhesion Molecules;Cell Physiology;Cell surface;Cells;Characteristics;Clinical;Cytoplasm;Cytoskeletal Modeling;Cytosolic Phospholipase A2;Defect;density;Deposition;E-Selectin;early detection biomarkers;Endothelium;extracellular;Extracellular Fluid;Fluorescence Microscopy;Ganglia;Gender;Hemorrhage;Human;ICAM2 gene;indexing;Inflammation;Inflammatory;innovation;insight;Intercellular adhesion molecule 1;interdisciplinary approach;Lead;Leucocytic infiltrate;Measures;mechanical force;Mechanics;Mediating;Membrane;meter;Methods;migration;monocyte;mouse model;Mus;NADPH Oxidase;Nerve Degeneration;Neurofibrillary Tangles;Neurons;neuroprotection;neurovascular;Optical Coherence Tomography;Oxidants;Oxidative Stress;Oxidative Stress Induction;P-Selectin;p65;Pathology;Pathway interactions;peripheral blood;Phosphorylation;Physiological;polymerization;Polymers;Probability;protein expression;Reporting;Research;Resolution;response;Retina;retina blood vessel structure;Role;Selectins;Side;statistics;Study models;tau aggregation;tau Proteins;Testing;Tg2576;Therapeutic;Thick;Thinness;Transgenic Mice;Up-Regulation;Vascular Cell Adhesion Molecule-1;Vascular Diseases

PROJECT_TITLE: Roles of Tau Oligomers in Alzheimer's Vasculopathy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – ADMINISTRATIVE CORE The Administrative Core plays a central role in orchestrating the MIT Superfund Research Program (SRP) so that many types of data can be combined to gain knowledge that will guide decisions on safety and cleanup, and so that work can be done hand-in-hand with community members to detect and destroy hazardous chemicals using novel filtration devices (to be created by MIT SRP engineers). The Administrative Core creates and strengthens connections among members of the MIT SRP, and between the MIT SRP and other stakeholders at local, state, national, tribal and global levels. By ensuring effective teamwork within the MIT SRP and between the MIT SRP and its stakeholders, MIT research, teaching, training, and community engagement will be optimized for their greatest impact.

PROJECT_TERMS: Acceleration;Achievement;Adoption;Advocacy;Carcinogens;career;chemical safety;Chemicals;Collaborations;Communication;Communities;community engagement;Computing Methodologies;Data;Data Analyses;data integration;data management;data sharing;data streams;Devices;Dimethylnitrosamine;Discipline;Disease;drinking water;Educational process of instructing;Educational workshop;Engineering;Ensure;Environment;Environmental Health;Environmental Protection;experience;Exposure to;Family;Filtration;Fostering;Future;Goals;Government Agencies;Hazardous Chemicals;Hazardous Substances;Health;high throughput screening;Human;improved;Infrastructure;innovation;Intervention;investigator-initiated translational research;Knowledge;Lead;Leadership;Massachusetts;meetings;member;Mentors;Methods;Mission;Municipalities;Mutagens;N-nitrosodimethylamine;National Institute of Environmental Health Sciences;National Toxicology Program;next generation;Nitrosamines;novel;Passamaquoddy;Persons;Play;posters;Probability;programs;Public Health;remediation;Research;restoration;Risk;Role;Safety;Science;sensor;Source;success;Suggestion;Sum;Superfund;superfund chemical;superfund site;System;Systems Integration;Technology;Technology Transfer;Training;Translating;translational potential;Translational Research;Translations;tribal leader;tribal organization;Tribes;Underrepresented Students;United States Environmental Protection Agency;United States Food and Drug Administration;wasting;Water;water treatment;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

PI_NAMEs: ZACHOS, NICHOLAS CONSTANTINE (contact)

PROJECT_TERMS: Adopted;Adult;Apical;Award;Bacterial Infections;biobank;Biopsy;Cell Line;cell type;Cells;Childhood;Coculture Techniques;Collaborations;Colon;Confocal Microscopy;cytokine;Dendritic Cells;Emergency Situation;Enteral;enteroaggregative Escherichia coli;Enterobacteriaceae;enterotoxigenic Escherichia coli;Environment;Epithelial Cells;Epithelium;Escherichia coli;Excision;Exposure to;Freezing;Genes;Growth;Growth Factor;Human;human model;Immune;Immune response;Immunology;Innate Immune Response;intestinal epithelium;Intestines;intraepithelial;knock-down;Laboratories;Lamina Propria;lentivirally transduced;Lymphocyte;M cell;Macrophage;Maintenance;Measurement;Methods;Modeling;monocyte;monolayer;Mucin-2 Staining Method;novel;Operative Surgical Procedures;Oxygen;pathogen;Pathogenesis;Pathologic;Patients;pediatric patients;Perfusion;programs;Protocols documentation;Publishing;Quality Control;Research Personnel;Research Project Grants;Research Support;Resources;response;scaffold;Services;Shigella;Shigella Infections;Side;small hairpin RNA;Small Intestines;spheroids;stem cells;Study models;Surface;System;Techniques;three dimensional cell culture;Time;Tissues;tool;Training;Work

PROJECT_TITLE: Enteroid Core


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;HIV/AIDS;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among people living with HIV (PWH) including in sub-Saharan Africa where approximately 70% of the global population of PWH reside. However, CVD screening and prevention remains extremely limited in practice in that region, due in part to lack of patient-oriented research (POR) on diagnostic modalities and locally-derived risk prediction criteria. Dr. Mark Siedner is a clinician scientist and emerging leader in research on CVD among PWH who has an extensive track record of scientific mentorship in patient-oriented clinical research. This award will provide him the protected time and support to 1) develop a POR mentoring program on CVD research focused on PWH in sub- Saharan Africa, 2) grow the careers of promising scientists in this area, and 3) identify optimal CVD screening algorithms and risk prediction scores for PWH in the region.

PI_NAMEs: SIEDNER, MARK J (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Age;AIDS prevention;Algorithms;analytical tool;Angiography;Ankle;antiretroviral therapy;Area;Award;Biological Markers;Blood Pressure;Body mass index;C-reactive protein;Calibration;Carbon Monoxide;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Career Mobility;carotid intima-media thickness;CD4 Lymphocyte Count;Cessation of life;Chronic;Clinic;Clinical;Clinical Research;clinical risk;Code;cohort;Communicable Diseases;comorbidity;Coronary Arteriosclerosis;Coronary artery;Data;Data Science;Dedications;design;Detection;Development;Diabetes Mellitus;Diagnostic;diagnostic algorithm;diagnostic biomarker;diagnostic screening;diagnostic tool;Disease;Disease Management;Disease Outcome;disorder risk;Electrocardiogram;Environmental Risk Factor;Epidemiology;Event;FABP2 gene;Fellowship;fine particles;Framingham Heart Study;Funding;Genetic;Glycosylated hemoglobin A;Goals;Grant;Health;Health behavior;Health system;high risk population;HIV;Hospitalization;Hypertension;improved;indexing;Individual;Inflammation;Infrastructure;Intervention;Leadership;life span;Literature;Longitudinal cohort study;Machine Learning;machine learning method;Measures;medical schools;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Modality;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multiple chronic conditions;National Heart, Lung, and Blood Institute;next generation;novel;Obesity;Paper;patient oriented;patient oriented research;Patients;Peer Review;Persons;Physicians;Population;population based;predictive modeling;predictive tools;Prevalence;Prevention;Principal Investigator;programs;Public Health;Publications;Research;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Training;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Role;rural South Africa;Sampling;Science;Scientist;screening;Screening procedure;sex;Site;sociodemographic factors;South Africa;supervised learning;Techniques;Time;Training;Training Programs;Trust;Uganda;United States;United States National Institutes of Health;Validation;Viral Load result;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Mentoring patient-oriented research to improve cardiovascular health among people with HIV in sub-Saharan Africa


NIH_SPENDING_CATS: American Indian or Alaska Native;Data Science;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE – DATA MANAGEMENT AND ANALYSIS CORE Water near Superfund Sites and municipal drinking water are contaminated with potentially carcinogenic chemicals (N-nitrosamines), and the purpose of the MIT Superfund Research Program includes gaining a better understanding of the health effects and risks associated with exposure. The Data Management and Analysis Core makes the most of MIT SRP data by making sure anyone can learn from MIT SRP data (via data sharing), fostering collaborations among scientists, and by providing cutting-edge data analysis methods so that we can learn as much as possible from study results. The DMAC supports the MIT Superfund Research Program in accomplishing its goals of being better able to predict and prevent diseases caused by these hazardous chemicals, and of using knowledge of exposure risks to guide decisions on cleanup.

PI_NAMEs: LEVINE, STUART S (contact)

PROJECT_TERMS: analytical method;Animal Model;Biological;biomarker development;Biomedical Research;Cancer Etiology;carcinogenicity;Carcinogens;Chemicals;Collaborations;Communities;community engagement;Computer Models;computerized tools;contaminated drinking water;Data;Data Analyses;data hub;data integration;data interoperability;data management;Data Management Resources;data quality;Data Set;data sharing;data streams;data submission;Dimethylnitrosamine;Discipline;Disease;diverse data;DNA Damage;Ensure;environmental chemical;Environmental Engineering technology;Environmental Science;FAIR principles;Family;Fostering;Goals;Hazardous Chemicals;Hazardous Substances;Health;Human;improved;Infrastructure;Intervention;Knowledge;knowledge integration;Learning;mathematical model;meetings;member;Methods;Mission;Molecular;Multiomic Data;multiple omics;Municipalities;Mutagens;N-nitrosodimethylamine;National Institute of Environmental Health Sciences;Nitrosamines;Nitroso Compounds;novel;Passamaquoddy;Pathway interactions;Persons;phenotypic data;prevent;Prevention strategy;Privatization;Probability;programs;Public Health;quality assurance;Quality Control;Regulation;remediation;Research;Research Personnel;Research Project Grants;Rest;Risk;Science;Scientist;sensor;success;Superfund;superfund chemical;superfund site;System;Techniques;Technology;Time;timeline;Training;Translational Research;tribal organization;Tribes;Update;Vision;Water;water sampling;water treatment;Work

PROJECT_TITLE: Core B: Data Management and Analysis Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Dietary Supplements;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nutrition;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative Vitamin A deficiency is a widespread problem in low-income countries and recently has been identified as a strong risk factor for developing clinical tuberculosis disease. This research aims to better understand the mechanisms by which a lack of vitamin A influences the ability of immune cells to respond to infection, and consequently, the outcome of tuberculosis disease. The goal will be to identify points in which vitamin A deficiency contributes to a more severe tuberculosis outcome in order to inform supplementation and host- directed therapies.

PI_NAMEs: PODELL, BRENDAN  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Affect;All-Trans-Retinol;Automobile Driving;Bacille Calmette-Guerin vaccination;BCG Vaccine;Biological Availability;Birth;Cause of Death;Cavia;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Chronic;Clinical;clinical development;Communicable Diseases;Communities;comorbidity;Country;COVID-19 pandemic;Data;Detection;Development;dietary;Dietary intake;Disease;Disease Outcome;Disease Progression;Environment;experimental study;Exposure to;Generations;Goals;Granuloma;guinea pig model;high risk;Human;human mortality;human subject;Image;Immune;immune function;Immune response;Immune System Diseases;Immunity;Impairment;in vivo;Individual;Infection;Infection Control;Intake;Isotopes;Knowledge;Laboratories;Liver;Location;low income country;Lung;lung development;Lung immune response;Malnutrition;Measures;Mediating;Metabolic;Metabolism;metabolomics;Methods;Morphology;Mycobacterium tuberculosis;Neonatal;neonate;Organ;Outcome;Pathogenesis;Pathologic;Pattern;physiologic model;Physiological;Predisposition;Pregnancy;prenatal exposure;Prevention;preventive intervention;Production;programs;progression risk;prophylactic;protective efficacy;Publishing;pulmonary granuloma;Research;response;Risk;Risk Factors;Role;Serum;single-cell RNA sequencing;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure of parenchyma of lung;Supplementation;T cell therapy;T-Lymphocyte;Therapeutic Intervention;transcriptomics;Tuberculosis;tuberculosis immunity;Vaccination;vaccination strategy;vaccine access;vaccine failure;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: Mechanisms of vitamin A-dependent risk for tuberculosis progression and prevention


NIH_SPENDING_CATS: American Indian or Alaska Native;Foodborne Illness;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE – COMMUNITY ENGAGEMENT CORE The mission of the MIT Superfund Research Program (SRP) Community Engagement Core (CEC) is to continue to strengthen robust bidirectional communication and collaborations with stakeholders that will make it possible to be responsive to the needs of community members by reducing the amount and toxicity of hazardous chemicals in the environment. The CEC will use tactile learning kits (invented by the CEC leader) to teach community members about how environmental chemicals can cause cancer and will work with educators to inspire underrepresented students to pursue research careers in environmental health. Working with the EPA, community members, and other MIT SRP members, the CEC will do Citizen Science research to reveal the amount of contamination in water, and will provide filters that will reduce the amount of hazardous chemicals in drinking water.

PI_NAMEs: VANDIVER, KATHLEEN MEAD (contact)

PROJECT_TERMS: Active Learning;Address;Adopted;Animal Model;Benign;Biology;Biomedical Research;Cancer Etiology;Carcinogens;career;Chemicals;Chemistry;citizen science;Collaborations;Communication;Communities;community collaboration;community engagement;contaminated water;Data;Data Analyses;data management;Devices;Dimethylnitrosamine;Disease;drinking water;Education;Educational Curriculum;Educational process of instructing;empowerment;Engineering;Environment;environmental chemical;Environmental Engineering technology;Environmental Health;environmental justice;Environmental Pollution;Environmental Science;Evaluation;experience;Family;Filtration;Foundations;Future;Goals;hands-on learning;Hazardous Chemicals;Hazardous Substances;Health;High School Faculty;Home;Human;Industrialization;informal support;innovation;Intervention;invention;Knowledge;Learning;learning community;Maps;Measures;member;Methods;Minority Groups;Mission;Municipalities;Mutagens;N-nitrosodimethylamine;National Institute of Environmental Health Sciences;Nature;next generation;Nitrosamines;Nitroso Compounds;Nonprofit Organizations;novel;Passamaquoddy;Persons;Play;Poison;prevent;Prevention;Privatization;Program Research Project Grants;programs;Public Health;remediation;Research;Research Project Grants;Risk;Role;Scientist;Secure;sensor;Social Responsibility;Soil;Stretching;Students;Superfund;superfund chemical;superfund site;synergism;System;Tactile;teacher;Technology;Toxic effect;toxicant;Training;Translational Research;Tribes;Trust;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Vision;Water;water treatment;Work;Youth

PROJECT_TITLE: Core C: Community Engagement Core


PI_NAMEs: PASETTI, MARCELA F (contact)

PROJECT_TERMS: 3-Dimensional;5 year old;adaptive immunity;antimicrobial;Apical;Award;base;Cause of Death;Cell Communication;Cell Lineage;Cell model;cell motility;Cell Physiology;Cell Separation;Cell Survival;Cell-Matrix Junction;Cells;cellular imaging;chemokine;Child;Coculture Techniques;Collagen;Collagen Type IV;Complex;Computer software;Confocal Microscopy;Culture Media;cytokine;cytotoxicity;Data;data acquisition;Data Analyses;Dendritic Cells;Development;diarrheal disease;Engraftment;enteric infection;enteric pathogen;Epithelial Cells;Epithelium;Equipment;Escherichia coli;Event;Experimental Designs;experimental study;Flow Cytometry;Generations;Gut Mucosa;Histology;Homeostasis;Host Defense;host-microbe interactions;Human;human model;Immune;Immune response;Immunity;Immunofluorescence Microscopy;Immunologics;Immunology;improved;Individual;Infection;Inflammation;innate immune function;insight;intestinal epithelium;Intestinal Mucosa;intraepithelial;Knowledge;Lymphocyte;Macrophage;Mediator;Membrane;Methods;Microarray Analysis;Microscopy;migration;Modeling;Molecular;Monitor;monocyte;monolayer;Morphology;Movement;Mucous Membrane;neutrophil;novel;particle;pathogen;Pathogenesis;peripheral blood;Permeability;Phagocytes;Phenotype;Physiological;Population;Porosity;Prevention strategy;Process;Production;programs;prophylactic;Protocols documentation;Reader;Research Project Grants;Research Support;response;Role;scaffold;Services;Shigella Infections;Side;Structure;Support System;Surface;synergism;System;T-Lymphocyte;Technical Expertise;therapeutic development;Tissues;Training;Work;Writing

PROJECT_TITLE: Immunology Core