NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The characterization of novel small molecules identified in high-throughput screening assays will allow the development efficacious therapies for neurological manifestations of a lysosomal leukodystrophy known as globoid-cell leukodystrophy, or Krabbe disease. This is an inherited lysosomal disorder that is currently screened at the neonatal period. There is an unmet need for efficacious and safer therapies to arrest and eventually revert the neurological course of this neurological condition.

PI_NAMEs: MAEGAWA, GUSTAVO HENRIQUE BOFF (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Affect;Age;analog;Binding;Biochemical;Biological Assay;blood-brain barrier crossing;blood-brain barrier penetration;Brain;brain cell;Cell Line;Cells;Central Nervous System;cytotoxic;Demyelinations;Development;Diagnosis;Diffuse;disabled;efficacious treatment;established cell line;Evaluation;Excision;Galactose;galactosylceramidase;Genetic;Globoid cell leukodystrophy;Goals;Hematopoietic Stem Cell Transplantation;high throughput screening;Histologic;Human;Hydrolase;improved;In Vitro;in vivo;Inherited;leukodystrophy;Libraries;Lysosomal Storage Diseases;Modeling;Monitor;mortality;mouse model;Mus;mutant;Mutation;Myelin;Nature;neonatal period;Neonatal Screening;nerve stem cell;neurobehavioral;Neurologic;Neurologic Symptoms;Newborn Infant;novel;Oligodendroglia;Outcome;parent grant;Patients;Peripheral Nervous System;pharmacokinetics and pharmacodynamics;Phenotype;Physiological;Positioning Attribute;prevent;Prevention;Property;Psychosine;Reducing Agents;Residual state;Schwann Cells;screening;screening program;small molecule;small molecule therapeutics;Sphingolipids;Testing;Therapeutic;Therapeutic Agents;Transplant Recipients;Validation;Wheelchairs

PROJECT_TITLE: Characterization of Small Molecule Therapeutic Agents for a Lysosomal Leukodystrophy


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Tumors affecting the brain, with the most devastating type a Diffuse Intrinsic Pontine Glioma (DIPG) with the H3K27M mutation, result in more cancer-related deaths than any other type of tumor in children. The major pathologic finding in H3K27M tumors is a global loss of H3K27me3 that dramatically change gene expression and are likely to function as drivers of malignancy in these tumors. Our goal is to develop new therapies for treating children with H3K27M tumors by developing a toolbox of primary and secondary assays and to identify small molecule compounds that increase the suppressed H3K27me3 levels and leads to H3K27M mutant tumors death.

PI_NAMEs: DANIELS, DAVID  (contact)

PROJECT_TERMS: Acetylation;Affect;Amino Acids;anti-cancer;Antineoplastic Agents;Biological;Biological Assay;Biological Markers;Brain;Brain Neoplasms;Brain Stem Neoplasms;cancer cell;cancer therapy;Cell Line;Cell Maintenance;Cell Survival;cell type;Cells;Cessation of life;Chemicals;Child;Childhood Glioma;Childhood Malignant Brain Tumor;Clinical Trials;CRISPR/Cas technology;Data;design;Development;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;Diversity Library;Dose;drug repurposing;Drug Screening;Enhancers;Ensure;Epigenetic Process;epigenome;Gene Expression;Gene Silencing;Genes;glioma cell line;Goals;H3 K27M mutation;Heterogeneity;high throughput screening;Histone H3;Image;Immunofluorescence Immunologic;innovation;Libraries;life span;Link;Lysine;Malignant Neoplasms;Methionine;Methylation;methylation pattern;Morphologic artifacts;Mutation;Names;neoplastic cell;Normal Cell;novel;novel therapeutics;palliative;Pathologic;Patients;Pediatric Neoplasm;pediatric patients;Performance;Pharmaceutical Preparations;Phase;Play;Primary Brain Neoplasms;Proliferating;Reproducibility;Research;response;Role;screening;small molecule;Somatic Mutation;Specificity;stem cell differentiation;success;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Agents;tool;Toxic effect;tumor;tumorigenesis;Validation;Vision

PROJECT_TITLE: Development of A High-Throughput Screen for Identification of Targeted Therapies in Brainstem Tumors with the H3K27M Mutation

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Traumatic brain injury (TBI) is a major cause of death and disability in developed societies. Every year, approximately 3.5 million Americans sustain a TBI, of which 50,000 die, and another 300,000 are hospitalized and survive the injury. This proposed study focuses on the most severely injured of this group, approximately 27,000 Americans each year who experience prolonged coma from a TBI, and require sophisticated care in neurological Intensive Care Units. This group experiences high rates of mortality and morbidity, and only 20% make a good recovery resulting in an enormous psychosocial burden on patients, their families, and society. This study proposes to determine whether a treatment protocol based on brain tissue oxygen monitoring, using technology that has been available for over 10 years, improves neurologic outcome in this most severely injured group of patients.

PI_NAMEs: BARSAN, WILLIAM G (contact);DIAZ-ARRASTIA, RAMON ;SHUTTER, LORI ;YEATTS, SHARON DZIUBA

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Abbreviations;Admission activity;Adopted;Adverse event;American;Area;Behavior assessment;behavioral outcome;Brain;Brain Hypoxia;Brain Injuries;brain tissue;Caring;Cause of Death;Classification;clinical center;clinical efficacy;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;clinically relevant;Cognitive;cognitive testing;Coma;Conscious;Control Groups;cost estimate;Data;Death Rate;design;Devices;disability;effective intervention;Emergency Care;Enrollment;experience;Family;functional improvement;Glasgow Coma Scale;Glasgow Outcome Scale;Head;Hospitalization;Hospitals;Hour;Hypoxia;improved;Informed Consent;Injury;innovation;Intensive Care Units;Intervention;Intracranial Hypertension;Intracranial Pressure;Left;Lifelong disability;Measures;Medical;Monitor;Morbidity - disease rate;nerve injury;Neurologic;Neurological outcome;neurosurgery;Outcome;Outcome Measure;Oxygen;Partial Pressure;Participant;participant enrollment;Patient Monitoring;Patients;Phase;phase III trial;Post-Head Injury Coma;prevent;primary outcome;Procedures;Protocols documentation;psychosocial;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;Safety;secondary outcome;severe injury;Severities;Societies;Specific qualifier value;Supportive care;Technology;Time;Traumatic Brain Injury;Treatment Protocols;trend;United States;United States Food and Drug Administration

PROJECT_TITLE: Brain Oxygen Optimization in Severe Traumatic Brain Injury - Phase 3 (BOOST-3)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: MONASH UNIVERSITY

PHR: Project narrative Microglial activation is increasingly recognized as an important component of the nervous system’s response to demyelinative injury in progressive multiple sclerosis (MS); however, our current inability to identify the nature and extent of the microglial response to injury limits our monitoring of the therapeutic response. Our proposed studies aim to fill this gap by developing a PET radioligand as a diagnostic tool that can differentiate the subsets of microglia in order to stratify MS patients. This stratification will allow a more accurate prediction of disease outcome and monitoring of therapeutic response, as well as the development of novel treatment strategies.

PI_NAMEs: STUPPLE, PAUL ANTHONY (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: ABCG2 gene;Adult;Affect;Affinity;Animal Model;Anti-Inflammatory Agents;Autoradiography;Binding;Binding Sites;Biological Markers;Biological Process;blood-brain barrier permeabilization;Brain;C57BL/6 Mouse;Caucasians;Cells;Classification;Clinical;Clinical Trials;Cuprizone;cytokine;design;Development;Diagnostic;Diagnostic Reagent;diagnostic tool;differential expression;Digit structure;disability;Disabling;Disease;Disease Outcome;Dose;economic cost;Equipment;Exhibits;Failure;FLT3 gene;Fluorides;Fluorine;Freezing;Future;Genes;glial activation;Image;imaging approach;Immune;Immunohistochemistry;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;Injury;kinase inhibitor;Kinetics;Laboratories;Lead;Lesion;Ligands;Link;Macrophage;Measures;Mediator;Medical Care Costs;MERTK gene;Microglia;Microsomes;Modeling;Monitor;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Mus;nanomolar;Nature;Nerve Degeneration;Nervous System;Nervous System Disorder;next generation;non-invasive imaging;novel;Outcome;Pathogenesis;Pathogenicity;patient stratification;Patients;Penetration;Pharmaceutical Preparations;Phase;Phenotype;Positron-Emission Tomography;Predisposition;Property;Proteins;Radioactive;radiochemical;Radiochemistry;radioligand;radiotracer;Receptor Protein-Tyrosine Kinases;repaired;Research;response;response to injury;Rodent;Route;Scanning;selective expression;Signal Transduction;Slice;Solubility;Stratification;Structure;success;Techniques;Testing;Therapeutic Intervention;Time;Tissues;tool;Tracer;Translational Research;treatment response;treatment strategy;uptake;Variant;Work;young adult

PROJECT_TITLE: Development of 18F PET radiotracers for M2 microglia as diagnostics for multiplesclerosis pathogenesis

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Parents may struggle to adjust to first-time parenthood, but the mechanisms underlying parents’ mental health symptoms during this period are not well understood. Though sleep quality is associated with mental health symptoms and white matter microstructure (WMM), no study has examined the role of sleep quality on parents’ mental health symptoms and WMM during the transition to parenthood. The proposed study examines sleep quality in new fathers at six months postpartum and tests associations with their WMM and mental health symptoms at one year postpartum, with the goal of identifying modifiable policy and practice targets to support parents’ adjustment to parenthood.

PI_NAMEs: CARDENAS, SOFIA ISABELA (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: actigraphy;Affect;Anisotropy;Behavior;biobehavior;Brain;brain health;caregiving;Child;Child Development;Child Rearing;Clinical;Data;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Ecological momentary assessment;Event;experience;Family;Family Study;father role;Fathers;Foundations;Goals;Health;healthy pregnancy;improved;Infant;insight;Intervention;Life;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Mediator;Mental Depression;Mental Health;Mothers;National Institute of Child Health and Human Development;Neurobiology;neuroimaging;novel;Parents;Patient Self-Report;perceived stress;Personal Satisfaction;Policies;poor sleep;Postpartum Period;prenatal;Psychological adjustment;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Role;Sampling;Shapes;Sleep;Sleep Deprivation;Sleep disturbances;sleep quality;Stress;Structure;Symptoms;Testing;Time;Training;Translating;Well in self;white matter;Work

PROJECT_TITLE: The role of fathers' sleep quality and white matter microstructure on the adjustment to parenthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Project Narrative The symptoms of Essential Tremor (ET), the most common movement disorder in adults, are seriously disabling. Deep brain stimulation is a very effective treatment strategy to control tremor, however, efficacy can wane over time and side effects can develop, likely due to an incomplete understanding of the network effects of chronic stimulation. The work proposed in this study, to perform imaging analysis of deep brain stimulation over time, will advance our understanding of the larger network response to stimulation so that a biomarker may be identified for an improved future treatment paradigm.

PI_NAMEs: FENOY, ALBERT J (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acute;Adult;Ataxia;Atlases;Axon;Biological Markers;biomarker identification;Blood flow;Brain;Brain region;Cell Nucleus;Cerebellum;Chronic;Clinical;clinical effect;Contralateral;Deep Brain Stimulation;Dentate nucleus;Development;Diffusion;Disabling;Disease;effective therapy;Electrocorticogram;Electrophysiology (science);Essential Tremor;Evolution;Exhibits;Failure;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gait Ataxia;Goals;Image;imaging modality;Implant;improved;Individual;innovation;insight;Knowledge;Lesion;Limb Ataxia;Maps;Mediator;Metabolic;Methodology;Methods;Modeling;Motor;Motor Cortex;Movement Disorders;Network-based;novel;Operative Surgical Procedures;Output;Pacemakers;Paresthesia;Parietal;Parietal Lobe;Pathology;Pathway interactions;Patient Selection;Patients;Periodicity;Pharmaceutical Preparations;Positron-Emission Tomography;prospective;recruit;Red nucleus structure;response;Rest;Role;serial imaging;side effect;Symptoms;Techniques;Thalamic structure;theories;Therapeutic;Therapeutic Intervention;Time;tool;tractography;Travel;treatment response;treatment strategy;Tremor;visual motor;Work

PROJECT_TITLE: Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor after successful Deep Brain Stimulation to the dentato-rubrothalamic tract

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Pediatric

ORG_CITY: SHEFFIELD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF SHEFFIELD

ORG_ZIPCODE: S10 2GW

PHR: Project Narrative Providing more effective therapies for impaired awareness of hypoglycemia (IAH) will allow more people with type 1 diabetes (T1D) to safely achieve target glucose and reduce the incidence of diabetic complications. This work may also highlight potential opportunities for basic scientists to better understand fundamental mechanisms and develop specific therapeutic interventions for IAH. Improving the ability of individuals to recognise the onset of hypoglycemia will allow people with T1D to improve their quality of life by reducing anxiety, fear of hypoglycemia and diabetes distress.

PI_NAMEs: HELLER, SIMON RICHARD (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adult;Affect;Age;aged;Anxiety;anxiety reduction;arm;Attitude;autonomic neuropathy;Awareness;Behavior;Blood Glucose;C-Peptide;Cardiovascular Diseases;Characteristics;Clinical;Clinical Trials;Closure by clamp;Cognitive;comparative efficacy;compare effectiveness;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;diabetes distress;Diabetes Mellitus;Education;Educational Intervention;effective intervention;effective therapy;Enrollment;Epinephrine;evidence base;Exclusion;Exhibits;follow-up;Fright;Glucose;Glucose Clamp;Glycosylated hemoglobin A;Heterogeneity;high risk;Hormones;human very old age (85+);Hybrids;Hyperglycemia;Hyperinsulinism;Hypoglycemia;Impairment;improved;Incidence;Individual;insight;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Studies;Intervention Trial;Measures;Mental Depression;Modernization;older adult;Older Population;Outcome Measure;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Peripheral Nervous System Diseases;Persons;Population;primary outcome;programs;psychoeducation;psychoeducational intervention;Pump;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;recruit;Recurrence;Reporting;Research;response;restoration;Running;Safety;Scientist;secondary outcome;Self Care;success;Symptoms;targeted treatment;Technology;technology intervention;Therapeutic Intervention;therapeutically effective;therapy design;Time;Training;treatment arm;two-arm study;Work

PROJECT_TITLE: Utilizing an RCT Approach to Compare the Efficacy and Sustainability of Technological and Psycho-Educational Interventions to Improve Impaired Awareness of Hypoglycemia in Type 1 Diabetes.


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MONKTON

ORG_NAME: HHT FOUNDATION INTERNATIONAL, INC.

ORG_STATE: MD

PHR: Project Narrative One half of the 50,000 U.S. HHT patients are anemic, with bleeds and symptoms currently meeting the risk:benefit balance for pazopanib therapy. Nosebleeds critically limit daily activities, while anemia and iron deficiency reduce productivity and lead to the use of substantial medical resource. Pazopanib has the opportunity to change the lives of these patients.

PI_NAMEs: GOSSAGE, JAMES RICHARD (contact)

PROGRAM_OFFICER_NAME: PIAO, YUNSHANG

PROJECT_TITLE: A Phase II/III randomized, placebo controlled, double blind study to evaluate the effects of up to 24 weeks of low dose pazopanib on HHT related epistaxis and anemia. IND#144808 June 25, 2020


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: Thousands of Veterans suffer a stroke every year, and these individuals often suffer emotional and cognitive changes that negatively affect their quality of life as well as their ability to recover. In addition to traditional rehabilitation such as physical and occupational therapy, a number of alternative treatments are now being studied for their ability to enhance patients’ recovery following stroke. One of these treatments, Mindfulness-Based Stress Reduction or MBSR, involves an 8-week course that teaches individuals strategies such as breathing techniques, meditation, and movement therapy. The current study proposes to teach MBSR to a group of Veterans with a history of stroke to determine whether this type of intervention has beneficial effects on psychological and cognitive functioning. We hope to find that MBSR is a useful, additional intervention that can improve Veterans’ well-being and quality of life as they recover from stroke.

PI_NAMEs: BALDO, JULIANA V. (contact)

PROJECT_TERMS: active comparator;active control group;Acute;Address;Affect;Alternative Therapies;alternative treatment;American;Anxiety;anxiety symptoms;Area;Attention;Awareness;Blinded;Blood Vessels;brain health;Brain Injuries;Brain region;Breathing;Caring;Chronic;Chronic Phase;chronic stroke;Clinical;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive task;cognitive testing;comparison group;Control Groups;Coping Skills;cost;daily functioning;Data;depressive symptoms;disability;Disease;Educational process of instructing;Emotional;Evaluation;Event;evidence base;follow up assessment;follow-up;Future;Goals;Hour;Impaired cognition;improved;Individual;Injury;innovation;Instruction;instructor;Intervention;Left;Lesion;Literature;Location;Longterm Follow-up;Magnetic Resonance Imaging;Maps;Measures;Meditation;Mental Depression;military veteran;mindfulness-based stress reduction;Movement;Music Therapy;neural correlate;Neuropsychology;novel strategies;Occupational Therapy;Outcome Measure;Participant;Patients;Performance;Personal Satisfaction;Phase;Physical therapy;Pilot Projects;Play;post intervention;predicting response;Prediction of Response to Therapy;predictive marker;Prefrontal Cortex;primary outcome;psychologic;Publishing;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;randomized, controlled study;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;reduce symptoms;Rehabilitation therapy;Research;Resources;Risk;Risk Reduction;Role;secondary outcome;Short-Term Memory;Site;Standardization;stress reduction;stress symptom;Stroke;stroke patient;symptomatology;Symptoms;System;Teacher Professional Development;Techniques;Testing;Time;Training;treatment group;treatment risk;Veterans;Well in self;Work;Yoga

PROJECT_TITLE: Mindfulness-Based Stress Reduction to Improve Neuropsychological Functioning in Acquired Brain Injury

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Over 80,000 Veterans with Parkinson’s disease (PD) obtain their medical care within the Veterans Administration (VA) Health Care System and this number is expected to increase due to the greater longevity of the population. Health-Related Quality of life (HRQoL), cognition, and mood are compromised in those with PD and worsen as the disease progresses. Interventions that target cognitive and mood symptoms as well as improve HRQoL are critically needed. Preliminary evidence indicates that Mindfulness-Based Stress Reduction (MBSR) is a promising behavioral intervention for HRQoL, cognition, and mood in PD; however, a systematic randomized controlled trial (RCT) is needed to establish efficacy and determine long-term benefits. The aims of this proposed study will address this need and are consistent with the VA’s clinical care goals. Findings will potentially greatly benefit the VA and its role as a leader in providing high quality care and empirically-validated treatments to Veterans.

PI_NAMEs: SCHIEHSER, DAWN M. (contact)

PROJECT_TERMS: active control;Activities of Daily Living;Aftercare;Anxiety;associated symptom;Attention;Attenuated;behavioral health intervention;Blinded;Caring;Chronic;Climacteric;clinical care;Cognition;Cognitive;cognitive ability;Communication;Control Groups;Data;disabling disease;Disease;efficacious treatment;efficacy evaluation;Enrollment;Ensure;Evaluation;executive function;experience;follow up assessment;follow-up;Frequencies;Future;Goals;health related quality of life;Healthcare Systems;Impaired cognition;improved;indexing;Individual;Intervention;Longevity;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Medical;Memory;Mental Depression;mindfulness;mindfulness-based stress reduction;Mission;Modeling;mood symptom;Moods;Motor;motor symptom;Nervous System Disorder;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurologic;Neuropsychological Tests;non-demented;non-motor symptom;Nonpharmacologic Therapy;older adult;Outcome;Outcome Measure;Parkinson Disease;Participant;Patients;Pilot Projects;pilot trial;Population;post intervention;primary outcome;programs;psychoeducation;Publishing;Quality of Care;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Role;Sample Size;Sampling;secondary analysis;Severity of illness;social stigma;Social support;Supportive care;Symptoms;Testing;Time;treatment comparison;treatment response;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Well in self

PROJECT_TITLE: Mindfulness Based Stress Reduction for Parkinson's Disease: A Longitudinal Study


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Chronic pain symptoms are very common among U.S. Military Veterans and have a profound negative impact on mental health symptoms and quality of life, in addition to increasing risk for suicidal ideation and suicidal behaviors. There are currently extremely few safe and effective pharmacological treatments for chronic pain disorders, and the clinical need to develop new therapeutics for pain has never been more urgent. Fueled by the worsening opioid crisis and further exacerbated by the COVID-19 pandemic, opioid and other drug overdose deaths have climbed to staggeringly high levels. The rapid development of medications for the management of chronic pain conditions that are safe, well-tolerated, efficacious and non-addicting is thus of paramount importance. The two neurosteroid candidates to be investigated in this trial are naturally occurring molecules enriched in human brain and potentially ideal candidates for safe and effective chronic pain treatment.

PI_NAMEs: MARX, CHRISTINE E.;NAYLOR, JENNIFER C (contact)

PROJECT_TERMS: Absence of pain sensation;active duty;addiction;adverse outcome;Affect;Afghanistan;Aftercare;Allopregnanolone;American;Anxiety;associated symptom;Back Pain;Biological Markers;Brain;Brief Pain Inventory;candidate marker;Caring;Central Nervous System;Cessation of life;Chest Pain;Chronic;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;COVID-19 pandemic;daily pain;Data;dehydroepiandrosterone;design;Development;Diagnosis;Dose;dose information;Double-Blind Method;double-blind placebo controlled trial;Drug Kinetics;effective therapy;efficacy evaluation;Electrocardiogram;Exhibits;Feeling suicidal;flexibility;Functional disorder;Human;improved;Intervention;Investigation;Iraq;Laboratories;Lead;Life;Low Back Pain;Mass Spectrum Analysis;Measures;Medical;Medication Management;Mental Depression;Mental Health;metabolic profile;Methodology;Methods;Military Personnel;military veteran;Monitor;neurosteroids;non-opioid analgesic;novel;novel therapeutic intervention;novel therapeutics;Numeric Rating Scale;Opioid;opioid epidemic;opioid use;overdose death;Pain;Pain Disorder;Pain intensity;Pain interference;Pain management;pain reduction;pain symptom;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;phase II trial;Phase III Clinical Trials;Placebo Control;Placebos;Play;Population;pre-clinical;preclinical study;Prediction of Response to Therapy;predictive marker;Pregnenolone;primary endpoint;Publishing;Quality of life;Randomized;randomized, clinical trials;Reporting;Research Design;Risk Factors;Role;Safety;secondary endpoint;Serum;suicidal behavior;suicidal risk;Supplementation;Symptoms;Therapeutic;three-arm trial;Translating;Treatment Efficacy;treatment optimization;trial design;Veterans

PROJECT_TITLE: Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURP-N (01)]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: VA use of prescribed stimulants (PS) has skyrocketed > 400% since 1999. VA’s upcoming Psychotropic Drug Safety Initiative (PDSI) will target PS. This grant uniquely supports the PDSI by using VA’s nationwide data to support the safer use of PS. We will identify patient groups at higher risk of adverse outcomes from PS (mortality, overdose, psychosis, mania, and substance abuse), and quantify the amount of increased risk. This will enable our Partners (OMHSP & PBM) to promote reduced use or increased monitoring of PS in these high- risk groups. We will also quantify risks attributable to prescriber choices, such as prescribing certain forms (immediate versus extended release) or high doses of PS, or choosing to continue PS despite “warning signs” (e.g., tox screen results). Findings will directly inform the PDSI as it occurs. We will then develop an implementable risk score, similar to VA’s opioid risk tool, to help providers assess PS risks for specific patients, who may have multiple risk factors. This study will improve care for thousands of Veterans receiving PS.

PI_NAMEs: SMITH, ERIC G. (contact)

PROJECT_TERMS: Academic Detailing;Address;Adopted;Adoption;Adverse effects;adverse outcome;Area;atomoxetine;Attention deficit hyperactivity disorder;attributable risk;Benzodiazepines;Cardiac;Cardiovascular Diseases;Cardiovascular system;Caring;Cause of Death;Clinical;clinical database;Clinical Practice Guideline;Communication;Counseling;dashboard;Data;Data Files;Databases;Decision Making;Detection;Development;Diagnosis;disorder risk;Dose;Education;Event;follow-up;Formularies;Frequencies;Grant;Health;high dimensionality;high risk;high risk population;Hospitalization;human old age (65+);Hybrids;hypomania;Implementation readiness;improved;innovation;Investigation;Label;Lead;Link;Logistic Regressions;Manic;Manuals;Medicare/Medicaid;medication safety;Mental Health;Methodology;Methods;Modeling;Monitor;mortality;mortality risk;Newly Diagnosed;novel strategies;older patient;Opioid;Outcome;Overdose;Pathway interactions;patient safety;Patients;Pharmaceutical Preparations;pharmacy benefit;physical conditioning;prescription opioid;programs;Provider;provider communication;Psychoses;Psychotropic Drugs;random forest;Recording of previous events;Reporting;Research;Resources;Risk;Risk Assessment;Risk Factors;risk mitigation;risk perception;risk stratification;Safety;Screening Result;Signal Transduction;Stimulant;stimulant use;stimulant use disorder;Structural Models;Substance abuse problem;substance use;Substance Use Disorder;Suicide;Suicide prevention;support tools;Surveys;Text;tool;Toxicology;Veterans;Work

PROJECT_TITLE: Identifying Safe Stimulant Prescribing Practices to Protect Patients, Inform Key Program Initiatives, and Assist Providers

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: RICHMOND

ORG_DEPT: NEUROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Myotonic dystrophy causes progressive disability and premature death. This proposal seeks to develop the essential clinical research tools that are needed to evaluate new drug treatments for myotonic dystrophy. The long-term goal is to promote the development of treatments that prevent the disease, slow the progression, reduce the disability, or reverse the symptoms.

PI_NAMEs: JOHNSON, NICHOLAS ELWOOD (contact);THORNTON, CHARLES A

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type-1 (Renewal)


PHR: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and difficult to treat cancer, with an overall 5-year survival rate of 9%. PDAC is a leading cause of cancer death affecting the VA population and most of these deaths are the result of cancer metastases. Pancreatic cancer is characterized by a stiff extracellular matrix that increases tissue pressure and shear stress. We recently discovered that these forces enhance pancreatic cancer growth and metastasis. This project will investigate the molecular mechanism by which mechanical forces affect PDAC and provide a strategy for treating pancreatic cancer and reducing metastases.

PI_NAMEs: LIDDLE, RODGER A. (contact)

PROJECT_TERMS: Acinar Cell;Affect;Agonist;Calcium;Cancer Etiology;Cells;Cessation of life;Circulation;Collagen;Data;Disease;Ductal Epithelial Cell;Enzymes;Exocrine pancreas;extracellular;Extracellular Matrix;Fibroblasts;Fibronectins;Fibrosis;Fluids and Secretions;Gene Modified;Generations;Genetic;Growth;hepatic sinusoid;Hepatocyte;Human;IL8 gene;improved;improved outcome;In Vitro;in vivo;injured;Interleukin-6;Ion Channel;Knockout Mice;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;mechanical force;Mechanics;mechanotransduction;Mesenchymal;Metastatic Neoplasm to the Liver;Methods;Molecular;mortality;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Pancreas;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic stellate cell;pancreatic tumorigenesis;Patient-Focused Outcomes;pharmacologic;Phenotype;Piezo 1 ion channel;Population;pressure;prevent;Proteins;Role;shear stress;Signal Transduction;Site;stellate cell;Survival Rate;Testing;Therapeutic;Tissues;tool;transplant model;Transplantation;tumor growth;tumor microenvironment;tumor progression;Tumor Volume;Veterans

PROJECT_TITLE: Mechanosensing in Pancreatic Cancer and Metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


NIH_SPENDING_CATS: Contraception/Reproduction;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Social Determinants of Health;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The tight regulation of meiosis, the specialized cell division that results in haploid gametes (sperm and eggs) is crucial for proper ploidy (correct number of chromosomes). Perturbations in meiosis can lead to gametes with the wrong number of chromosomes, which is the leading cause of infertility, miscarriages, and birth defects. The results from this proposal will begin to determine the sex-specific mechanisms that contribute to gametes with the correct ploidy providing a further understanding for the differences in male vs. female infertility.

PI_NAMEs: ROURKE, CHRISTINE KIELY (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Affinity Chromatography;Alleles;Aneuploidy;aurora B kinase;Biochemical;Biochemistry;Caenorhabditis elegans;career;Cell division;Cells;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesion;Collaborations;Confocal Microscopy;Congenital Abnormality;Couples;Data;Delaware;Developed Countries;Developing Countries;Diploidy;DNA;egg;Ensure;Environment;Enzymes;Equipment;Ethnic Origin;Event;Exhibits;Faculty;Female;Female infertility;Fluorescence;Gametogenesis;Genetic;Genetic Crossing Over;Genetic Recombination;Germ Cells;Goals;Haploidy;Health;Homologous Gene;In Vitro;in vivo;Infertility;innovation;insight;Knowledge;Label;male;Meiosis;Meiotic Prophase I;Mentors;Mentorship;Microscopy;Mitosis;model organism;Molecular;Molecular Biology;mutant;nano;Nationalities;novel;Oocytes;Oogenesis;Organism;Pathway interactions;Persons;Phenotype;Physical condensation;Ploidies;Postdoctoral Fellow;precursor cell;programs;Prophase;protein complex;protein expression;protein protein interaction;Proteins;Race;Regulation;Research Personnel;Resolution;Resources;Role;segregation;sex;Sex Differences;sexual dimorphism;Sister Chromatid;skills;Socioeconomic Status;socioeconomics;sperm cell;Spermatogenesis;Spontaneous abortion;stoichiometry;success;Testing;Topoisomerase II;Training;Universities

PROJECT_TITLE: Characterizing the Sexually Dimorphic Role of Topoisomerase II During the Sister Chromatid Cohesion Release Pathway.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative  Increasing evidence indicates that, in a group of patients, Parkinson’s Disease (PD) may start in the gut and spread to the central nervous system via the vagus nerve. Indeed, gastrointestinal (GI) symptoms such as gastroparesis and constipation are prodromal to the onset of PD. We have discovered recently a nigro-vagal pathway that modulates colonic motility, and is impaired in an experimental model of PD. Based on our preliminary data, the present proposal aims to investigate the hypothesis that the GI hypomotility observed in PD induces a maladaptive plasticity in the nigro- vagal pathway that favors the progression of PD which, if corrected with therapeutic interventions, will slow down the progression of PD. Results from these studies will provide important translational information that will be used to target vulnerable patients and delay/ameliorate the progression of PD.

PI_NAMEs: BROWNING, KIRSTEEN NAIRN;SUBRAMANIAN, THYAGARAJAN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;alpha synuclein;Anatomy;Animal Model;Animals;Area;Attenuated;Behavioral;Bilateral;Binding Proteins;biomarker discovery;Brain Stem;Breath Tests;Cell Nucleus;Central Nervous System;Characteristics;Colon;Compensation;Confocal Microscopy;Constipation;Data;Development;Diet;dietary;Disease;Dopamine;dopaminergic neuron;dorsal motor nucleus;Dose;Electrophysiology (science);Enteral;Enteric Nervous System;Environment;Etiology;Exhibits;Experimental Models;Functional disorder;gastrointestinal;Gastrointestinal Motility;gastrointestinal symptom;Gastrointestinal tract structure;Gastrointestinal Transit;Gastroparesis;Generations;Genetic;gut-brain axis;Herbicides;Human;Human Resources;Hyperactivity;Idiopathic Parkinson Disease;Impairment;in vivo;inorganic phosphate;Intervention;Intestines;Lead;Lectin;Levodopa;Lewy Bodies;Microinjections;Midbrain structure;Modeling;Motility;Motor;motor behavior;motor deficit;Nerve Degeneration;Neural Pathways;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;Neurotoxins;nigrostriatal degeneration;novel;novel therapeutics;Oral;Paraquat;Parkinson Disease;Parkinsonian Disorders;pars compacta;patch clamp;Pathologic;Pathway interactions;Patients;Positioning Attribute;prevent;protein aggregation;Rattus;reduce symptoms;Regulation;Reproducibility;response;Rodent;Rodent Model;Role;Slice;Source;Squalamine;Stomach;Substantia nigra structure;sugar;Symptoms;synucleinopathy;Testing;Therapeutic Intervention;Time;tool;Vagus nerve structure

PROJECT_TITLE: Gut-brain axis in Parkinson's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The global SARS-CoV-2/COVID-19 pandemic, with unprecedented mortality rates of COVID-induced ARDS, has dramatically highlighted the critical role of lung endothelial cell (EC) dysfunction and permeability, the lack of key insights into ARDS pathobiology, the lack of key insights into ARDS health disparities, and the absence of FDA-approved ARDS pharmacotherapies. This competitive PPG renewal application maintains its highly translational focus on a key ARDS target, the lung endothelial cell, and the essential role of the EC cytoskeleton in the pathobiology of ARDS with the vascular endothelium as a highly druggable target to attenuate lung vascular permeability and inflammation and ARDS mortality.

PI_NAMEs: GARCIA, JOE G. N. (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;African ancestry;Animal Model;Arizona;Attenuated;Binding;Biochemical;Biophysics;Black race;Blood Vessels;Cell Line;Cell secretion;Circulation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;COVID-19 pandemic;COVID-19/ARDS;Cytoskeleton;Data;Death Rate;design;Development;druggable target;EMS1 gene;Endothelial Cells;Endothelium;Environment;FDA approved;Focal Adhesions;FRAP1 gene;Functional disorder;Genes;Genetic;Genetic Transcription;Genome;Genomics;health disparity;Illinois;Image;Inflammation;Inflammatory;Injury;insight;Integrin beta4;Leukocytes;Ligands;Ligation;Lung;lung injury;Mechanical Stress;Mediating;Microscopy;Miniature Swine;Mitogen-Activated Protein Kinases;Modeling;Molecular;mortality;Multiple Organ Failure;Myosin Light Chain Kinase;nicotinamide phosphoribosyltransferase;non-muscle myosin;novel;novel therapeutics;P-Selectin;P-selectin ligand protein;Pathway interactions;Pattern;Peripheral;Permeability;Pharmacotherapy;Physicians;pre-clinical;Protein Isoforms;Proteins;Proteome;Publishing;Pulmonary Circulation;Pyruvate Kinase;Rattus;receptor;recruit;Regulation;repaired;Reporting;Research Personnel;Resolution;response;Role;Scientist;Signal Transduction;Site;Sphingosine-1-Phosphate Receptor;Stimulus;Systems Biology;Therapeutic;TLR4 gene;Universities;Vascular Endothelium;vascular inflammation;vascular injury;Vascular Permeabilities;Ventilator-induced lung injury;Work

PROJECT_TITLE: Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

PROJECT_TERMS: Accounting;Acute Respiratory Distress Syndrome;Administrator;Agreement;Budgets;Charge;Chicago;cloud based;Collaborations;Communication;Cytoskeleton;data sharing;Endothelium;Ensure;Evaluation;Expenditure;experimental study;Fostering;Geographic Locations;Grant;high standard;Human Resources;Illinois;Individual;Institution;inter-institutional;Laboratories;Lung;meetings;member;Monitor;National Heart, Lung, and Blood Institute;operation;Peer Review;Periodicals;Persons;Principal Investigator;Productivity;programs;Reagent;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;Secure;Services;Structure;success;symposium;translational goal;Travel;Universities;Videoconferencing;virtual;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Genetics;Human Genome;Lung;Rare Diseases

PI_NAMEs: ELLIS, NATHAN A. (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Bioinformatics;Biological Assay;Blood Vessels;Cell Line;Cellular Structures;Code;Computer Models;Cytoskeleton;data platform;Data Set;Disease;DNA;DNA Methylation;DNA sequencing;EMS1 gene;Endothelial Cells;Endothelium;experimental analysis;Focal Adhesions;Gene Proteins;Generations;Genes;Genetic;genetic analysis;Genome;genome editing;genome-wide;Genomics;Human;Immunoprecipitation;in silico;Incidence;Inflammatory;Integrin beta4;ITGB4 gene;Knock-in;Knock-out;Lung;Mass Spectrum Analysis;Methylation;methylome;Modeling;Mutation;Myosin Light Chain Kinase;nitration;non-muscle myosin;Nucleotides;P-Selectin;Peripheral;Phosphorylation;Post-Translational Protein Processing;Predisposition;Production;promoter;protein function;protein protein interaction;protein structure;Proteins;Proteome;Proteomics;Recombinant Proteins;Regulation;Research;Research Personnel;restoration;Role;Sampling;Services;Severities;Signal Transduction;Single Nucleotide Polymorphism;Site;Sphingosine-1-Phosphate Receptor;Structural Models;Structure;Surface Plasmon Resonance;Testing;TLR4 gene;transcriptome sequencing;translational impact;Translational Protein Modification;Ubiquitination;Variant;Vascular Permeabilities

PROJECT_TITLE: Genomic/Genetic and Proteome


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biomedical Imaging;Biotechnology;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: SAMMANI, SAAD  (contact)

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Agonist;Albumins;animal care;Animal Model;Animals;antagonist;Arizona;Automobile Driving;Basic Science;Biochemical;Biological;Biological Assay;Blood capillaries;Blood Vessels;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Caring;Cell Count;Cellularity;Clinical;COVID-19 pandemic;COVID-19/ARDS;Cytoskeleton;Data Analyses;Death Rate;design;Dyes;efficacy testing;Endothelial Cells;Endothelium;Equipment;Evans blue stain;experience;experimental study;Extravasation;Family suidae;FDA approved;Focal Adhesions;Genomics;Goals;Housing;Imaging Techniques;Immunohistochemistry;in vivo imaging;indexing;Individual;inhibitor;Injury Severity Score;insight;Intervention;Leadership;Liposomes;Lung;lung histology;lung injury;Measurement;Miniature Swine;Modeling;Monoclonal Antibodies;mortality;novel therapeutic intervention;Patients;Performance;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Plasma;porcine model;pre-clinical;Pre-Clinical Model;preclinical efficacy;Proteins;Protocols documentation;PTK2 gene;Pulmonary Circulation;Pulmonary Inflammation;radiological imaging;Rattus;Recovery;Regulation;Reproducibility;Research Personnel;Resources;Respiratory System;response;Role;Services;Simvastatin;small molecule inhibitor;Sprague-Dawley Rats;Structure of parenchyma of lung;Techniques;Therapeutic;therapeutic development;Tissue Sample;tool;Training;Translations;UCHL1 gene;Ultrasonography;Universities;Vascular Permeabilities;Ventilator-induced lung injury;Western Blotting;Work

PROJECT_TITLE: Pre-Clinical Large and Small Animal Models of ARDS/VILI


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Lung;Nanotechnology;Rare Diseases

PI_NAMEs: GREGORIO, CAROL C (contact)

PROJECT_TERMS: 3-Dimensional;ABL1 gene;Acute Respiratory Distress Syndrome;Address;Arizona;Atomic Force Microscopy;Biological;biophysical analysis;Biophysics;Cells;cellular engineering;chemical property;Chicago;Complex;Computer software;Consultations;Core Facility;Correlative Study;Cytoskeleton;Data;Data Analyses;Data Set;Directories;DOCK1 gene;Doctor of Philosophy;EMS1 gene;encryption;Endothelial Cells;Endothelium;Engineering;Equipment;experience;experimental study;fabrication;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Focal Adhesions;Genetic;Genomics;Health Insurance Portability and Accountability Act;high resolution imaging;Human;Human Resources;Image;imaging study;Individual;instrument;Integrin beta4;Intercellular Junctions;Laboratories;laboratory facility;Laboratory Research;Lasers;live cell imaging;Lung;Measurement;Measures;Mechanics;Membrane;Microfabrication;Microscopy;Molecular;multimodality;Mutation;MYLK gene;Names;nano;Optics;Organelles;P-Selectin;paxillin;physical property;Post-Translational Protein Processing;Procedures;Process;Proteome;Quantitative Microscopy;receptor;Regulation;Research Personnel;Research Project Grants;Resolution;Resources;Retrieval;Sampling;Scanning;Scanning Probe Microscopes;Scanning Probe Microscopy;Scientist;Secure;Services;Signal Transduction;Site;Slide;Standardization;Structure;superresolution microscopy;System;Technology;Text;three dimensional structure;Time;tissue culture;TLR4 gene;tool;Traction Force Microscopy;Training;Transgenes;Universities;University resources;web portal

PROJECT_TITLE: Biophysical Imaging


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Orphan Drug;Rare Diseases

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;Address;Adhesions;Agonist;antagonist;Attenuated;Binding;Binding Proteins;Biophysics;Black Populations;Blood Vessels;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cytoskeletal Proteins;Cytoskeleton;design;DNA Methylation;DOCK1 gene;EMS1 gene;Endothelial Cells;Endothelium;Engineering;epigenetic regulation;Extracellular Matrix;Family suidae;Focal Adhesions;Genes;Genetic;genetic regulatory protein;Genetic study;genetic variant;Glycolysis;Goals;Guanosine Triphosphate Phosphohydrolases;health disparity;Human Genetics;Hypoxia;hypoxia inducible factor 1;Image;imaging modality;in vivo;Inflammation;Inflammatory;inhibitor;insight;Integrins;Leukocyte Trafficking;Link;Liposomes;Lung;Mechanical Stress;Mediating;Modality;Modeling;mortality;Multiple Organ Failure;Mus;Myosin Light Chain Kinase;non-muscle myosin;novel;novel therapeutics;Peptides;Peripheral;Permeability;Phosphorylation;porcine model;pre-clinical;Pre-Clinical Model;Predisposition;Process;promoter;Protein Isoforms;Proteins;Proteomics;Publishing;Pyruvate Kinase;Rattus;receptor;Receptor Activation;Regulation;response;restoration;Risk;RNA Splicing;Sepsis;Signal Transduction;Simvastatin;Structure;Surface;Systems Biology;Therapeutic;therapeutic target;therapeutically effective;TLR1 gene;TLR4 gene;transcription factor;Translating;translational approach;Trauma;Tyrosine;Tyrosine Phosphorylation;ultra high resolution;Variant;vascular inflammation;Vascular Permeabilities;Ventilator;Work

PROJECT_TITLE: Regulation of Peripheral EC Cytoskeletal Remodeling, Gap Closure and Barrier Restoration by nmMLCK/MYLK and Cortactin/CTTN


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;ATP-Binding Cassette Transporters;Attenuated;Automobile Driving;Bacterial Infections;Binding;Biological Markers;Blood Vessels;Cell Line;Cell secretion;Circulation;COVID-19 pandemic;COVID-19/ARDS;CRISPR/Cas technology;cytokine;Cytoskeleton;Data;Deubiquitination;Dimerization;DNA Methylation;Dose;efficacy validation;Endothelial Cells;Endothelium;epigenetic regulation;Event;Exposure to;extracellular;extracellular vesicles;Family suidae;FRAP1 gene;Functional disorder;Genetic;Genomics;HIF1A gene;Hyperoxia;Hypoxia;Hypoxia Inducible Factor;Inflammasome;Inflammatory;Injury;Knockout Mice;Ligation;Lung;lung injury;lung vascular inflammation;Mechanical Stress;Mechanical ventilation;Mediating;Mitogen-Activated Protein Kinases;Modality;Modeling;Molecular;Monoclonal Antibodies;mortality;Mus;new therapeutic target;nicotinamide phosphoribosyltransferase;nitration;novel;Organ;Pathway interactions;Pattern;Permeability;Plasma;porcine model;pre-clinical;preclinical study;Predisposition;Production;promoter;Proteins;Rattus;Regulation;response;Role;SARS-CoV-2 infection;Severities;Signal Transduction;Small Interfering RNA;Stimulus;Structure;synergism;Therapeutic;therapeutic target;TLR4 gene;transcription factor;ubiquitin isopeptidase;Ubiquitination;UCHL1 gene;Ventilator;Ventilator-induced lung injury;Vesicle;Viral

PROJECT_TITLE: Role of Endothelial eNAMPT/NAMPT secretion and TLR4 signaling in the ARDS Vascular Endotype


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Rare Diseases

PI_NAMEs: CRESS, ANNE E (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Acute Respiratory Distress Syndrome;Address;Adhesions;Alternative Splicing;Anti-Inflammatory Agents;Automobile Driving;Binding;Blood Vessels;Cell Adhesion Molecules;Cell membrane;Cells;Chimeric Proteins;Code;Complex;COVID-19 pandemic;Cytoplasmic Tail;Cytoskeletal Proteins;Cytoskeleton;DNA Methylation;EMS1 gene;Endothelial Cells;Endothelium;epigenetic regulation;Erinaceidae;Family suidae;Focal Adhesions;Functional disorder;Generations;Genes;Genetic;Genetic Polymorphism;health disparity;HIF1A gene;Inflammation;Inflammatory;inhibitor;insight;Integrin beta4;Integrin Binding;Integrins;Intercellular Junctions;Laminin;link protein;Liposomes;live cell imaging;Lung;lung injury;Mechanical Stress;Mechanical ventilation;mechanotransduction;Mediating;Modeling;Molecular;mortality;Multiple Organ Failure;mutant;nitration;novel;paxillin;Peripheral;pharmacologic;Phosphorylation;plectin;porcine model;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;promoter;Proteins;PTK2 gene;Pulmonary Circulation;Rattus;Reactive Oxygen Species;recruit;Regulation;response;restoration;Role;Signal Transduction;Signaling Molecule;Simvastatin;Site;Stimulus;Structure;Therapeutic;transcription factor;translational approach;ubiquitin-protein ligase;Variant;Vascular Permeabilities;Viral

PROJECT_TITLE: Functional Involvement of IntegrinB4/ITGB4 and Kindlin/FERMT2 in Focal Adhesion Dynamic Remodeling in ARDS


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Rare Diseases

PI_NAMEs: DUDEK, STEVEN M (contact)

PROJECT_TERMS: Actins;activated protein C receptor;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alveolar;analog;antagonist;Binding;Biological;Black Populations;Blood Vessels;CD44 gene;Circulation;Code;COVID-19 pandemic;Cytoskeleton;Data;demethylation;Deubiquitinating Enzyme;Deubiquitination;DNA Methylation;DOCK1 gene;effective therapy;efficacy evaluation;Endothelial Cells;Endothelium;epigenetic regulation;Exhibits;Extravasation;Family suidae;FDA approved;Floods;Focal Adhesions;G-Protein-Coupled Receptors;Genes;Genetic;Glycoproteins;GTP Phosphohydrolase Activators;Guanosine Triphosphate Phosphohydrolases;Immunoglobulins;in vivo Model;Inflammatory;inhibitor;insight;Intervention;Ligands;Ligation;Link;lipid mediator;Liposomes;Lung;lung injury;Mechanical Stress;Mediating;Membrane;microvesicles;Modeling;Morbidity - disease rate;mortality;Multiple Organ Failure;Mus;nitration;novel;P-Selectin;P-selectin ligand protein;Permeability;pharmacologic;porcine model;pre-clinical;Pre-Clinical Model;predictive marker;promoter;Proteins;Proto-Oncogene Proteins c-akt;Pulmonary Circulation;Rattus;receptor;Regulation;Research Personnel;response;rho GTP-Binding Proteins;Risk;Role;Selectins;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;survival prediction;Susceptibility Gene;targeted treatment;Therapeutic;therapeutic effectiveness;Thrombosis;trafficking;transcription factor;ubiquitin isopeptidase;UCHL1 gene;Vascular Endothelial Cell;Vascular Permeabilities;Weibel-Palade Bodies

PROJECT_TITLE: Crosstalk between S1P Receptor 1/S1P1 and P-Selectin/Selp in Regulation of Inflammatory Vascular Permeability


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Hazardous drinking is common among Veteran primary care patients and increases risk for more costly and complex medical problems over the long-term. Yet, the vast majority of these Veterans go untreated due to patient, provider, and organizational barriers. By providing an option for care that is easily accessible, private, and self-directed, mobile applications (apps) circumvent many of the often-cited barriers to alcohol use treatment. However, poor patient engagement remains the Achilles’ heel of these apps. Through supportive accountability, Peer Specialists can maximize the reach and engagement of these apps with patients and improve drinking outcomes. If successful, our proposed research has the potential to transform care and increase access to alcohol-related services for Veterans who engage in hazardous drinking but rarely seek treatment, and, in turn, mitigate the adverse health outcomes that stem from untreated hazardous drinking.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL (contact)

PROJECT_TERMS: Accountability;addiction;Adherence;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol seeking behavior;Alcohols;brief intervention;care delivery;care systems;Caring;Complex;connected care;cost;Coupled;Data;design;drinking;Drug usage;Effectiveness;effectiveness testing;eHealth;evidence base;Foundations;Gender;Goals;hazardous drinking;Health;Health Services Accessibility;Heavy Drinking;Human;human old age (65+);implementation trial;improved;informant;innovation;Intervention;Interview;Lived experience;Mediating;Mediator;Medical;medical specialties;Mental Health;Mental Health Services;Methodology;mobile application;Modeling;novel;novel strategies;Online Systems;Outcome;patient engagement;patient oriented;Patients;peer;peer support;Pilot Projects;Population;pragmatic trial;Primary Care;primary care patient;primary care visit;primary outcome;Privatization;Provider;psychiatric comorbidity;psychiatric symptom;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Recovery;recruit;Reporting;Research;Risk;Role;role model;routine screening;satisfaction;Secure;Self Care;Self Direction;Self Efficacy;Self Management;Services;Severities;Site;social stigma;Specialist;standard of care;stem;substance use;Suicide prevention;technological innovation;Telephone;telephone session;Testing;Time;tool;Training;Travel;treatment as usual;Veterans;virtual healthcare;Work

PROJECT_TITLE: Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking with Peer Phone Support

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Aging is the greatest risk factor for memory decline and associated pathologies, including Alzheimer’s disease. No treatments exist to slow or reverse memory decline, but this proposal will address this deficit by identifying new genes and small molecule regulators of long-term memory formation. By identifying new candidates involved in long-term memory, these experiments may lead to better therapeutics for maintaining memory function with age.

PI_NAMEs: STEVENSON, MORGAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Affect;Age;age related decline;Age-associated memory impairment;Aging;Alzheimer's Disease;Behavioral;Behavioral Assay;Biological Assay;Biological Models;Caenorhabditis elegans;Candidate Disease Gene;career;Chromatin;Code;cognitive ability;Cognitive aging;cognitive function;CREB1 gene;Data;Dementia;Disease;effective therapy;Emotional;Ensure;experimental study;Family;Fellowship;Financial cost;Gene Expression;Genes;Genetic;Genetic Transcription;healthspan;Impaired cognition;improved;infancy;Invertebrates;Knowledge;Learning;life span;Life Style;long term memory;Maintenance;member;Memory;memory consolidation;Memory Loss;Mentorship;Messenger RNA;Molecular;Mus;Nematoda;Nervous System;Neurodegenerative Disorders;Neuroglia;Neurons;Nuclear;Nuclear Receptors;Organism;Pathologic;Pathology;Pathway interactions;Patients;posttranscriptional;Prevalence;programs;Protein Biosynthesis;Proteins;rapid testing;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;RNA Interference;Role;Site;small molecule;Small RNA;social relationships;Societies;Supporting Cell;System;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;Training;Transcript;transcription factor;transcriptomics;Untranslated RNA;Vertebrates

PROJECT_TITLE: Identifying new mechanisms of long-term memory formation


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CLOQUET

ORG_NAME: FOND DU LAC RESERVATION

PHR: The Fond du Lac Band of Lake Superior Chippewa Regional Research Institute (FDL-RRI) brings together research, education, and tribal research capacity building in a tribal-led partnership to contribute to national efforts to reduce health disparities, improve mental and physical health outcomes, and ultimately promote health and wellness among American Indians and Alaska Natives (AIAN). Our projects are informed by AIAN key stakeholders and health researchers and have the potential to increase the availability of high-quality AIAN health data through the implementation of innovative science that will ultimately lead to improved health and the reduction of health disparities among American Indian and Alaska Native populations.

PI_NAMEs: DUNLAP, JACOB  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Accountability;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;career development;Chippewa;cohort;Collaborations;Communities;community clinic;community collaboration;community college;Data;Data Collection;data management;data repository;Dedications;Development;Disease;Education;Educational process of instructing;Employment Opportunities;empowerment;Epidemiology;Ethics;experience;Faculty;Fellowship;Fellowship Program;Fond du Lac;Fond du Lac Tribal and Community College;Foundations;Future;Goals;Great Plains;Health;health care service;health data;Health Disparities Research;Health Promotion;Health Surveys;improved;Indigenous;innovation;instrument;Intervention;Knowledge;Lead;Measurement;Measures;Mental Health;Mentors;Minnesota;minority health;Modeling;Native American community;Native American Research Center for Health;Outcome;physical conditioning;Policies;Prevention;programs;Psychometrics;Reduce health disparities;Research;research and development;Research Ethics;Research Institute;Research Personnel;Research Project Grants;Research Training;response;Science;Services;Site;Social Well-Being;Solid;Students;success;Surveillance Program;Time;tool;Training;transfer student;tribal college;tribal community;tribal health;Tribes;United States;Universities;Washington

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MOOSE, SAMUEL  (contact)

PROJECT_TERMS: Advisory Committees;Alaska Native;American Indian Population;American Indians;Chippewa;Collaborations;Communication;Communities;community clinic;community collaboration;community involvement;Data;Data Protection;Development;Documentation;Education;Employment Opportunities;empowerment;Ensure;Epidemiology;Evaluation;Event;experience;Fond du Lac;Fond du Lac Tribal and Community College;Fostering;Foundations;Goals;Grant;Health;Health Disparities Research;health disparity;Human;Human Subject Research;Indigenous;Infrastructure;innovation;Institution;Institutional Review Boards;Internships;Interview;Knowledge;Lead;Leadership;member;Minnesota;minority health;Monitor;Native American community;Native American Research Center for Health;next generation;Phase;Procedures;Productivity;Program Development;Protocols documentation;Recording of previous events;Research;Research Activity;research and development;Research Infrastructure;Research Institute;Research Project Grants;Resources;response;Role;Safety;Services;Site;social;Social Environment;Social Well-Being;Solid;sound;Strategic Planning;Structure;Students;Surveys;synergism;System;Training;Training Activity;training project;Travel;tribal community;Tribes;Universities;Washington;web site;Work

PROJECT_TITLE: Admin-Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Direct to consumer (DTC) marketing strategies, in which a service or product is advertised directly to the end user rather than a health care provider, are frequently used and highly effective at driving demand for psychotropic medications (e.g., Avery et al., 2012; Woloshin et al., 2001). DTC marketing may also be effective at driving Veteran demand for evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) because advertisements can directly target some of the primary barriers to EBP use. This proposal aims to develop DTC marketing advertisements for EBPs based upon established strategies from the marketing literature (e.g., testimonials, the utility strategy, and the compare/contrast strategy) and with input from Veteran, family member, and other stakeholders. In a randomized controlled trial, we will test their effectiveness at improving Veterans’ attitudes about psychotherapy, intention to seek psychotherapy, and initiation of a psychotherapy referral, compared to control conditions.

PI_NAMEs: HUNDT, NATALIE E (contact)

PROJECT_TERMS: Advertisements;Advertising;Attitude;Automobile Driving;Behavior;Budgets;Characteristics;Clinical;comparison control;demographics;Development;direct to consumer advertising;Education and Outreach;effective therapy;Effectiveness;effectiveness testing;Eructation;evidence base;Family member;Feedback;Focus Groups;General Population;Health Personnel;improved;insight;Intention;Intervention;Investments;Knowledge;Literature;Marketing;member;Mental Health;multidisciplinary;outreach;Participant;patient-level barriers;Patients;Pharmaceutical Preparations;Planning Theory;Post-Traumatic Stress Disorders;primary outcome;Provider;Psychotherapy;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;Reaction;recruit;relative effectiveness;Reporting;Research;Resources;response;service organization;Services;Site;social stigma;Symptom Burden;symptomatic improvement;tailored messaging;Target Populations;Testing;Theoretical model;Training;Treatment Effectiveness;uptake;Veterans;Work

PROJECT_TITLE: Direct to consumer marketing to engage Veterans in evidence-based psychotherapies for PTSD


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research will evaluate whether self-management of blood pressure (defined as pharmacist- guided Veteran-driven titration of blood pressure (BP) medications) is more effective than self-monitoring of home BP and the standard care in 160 Veterans with chronic kidney disease (CKD). The study will further evaluate Veteran characteristics that influence the acceptability of and the adherence to the self-management approach. Qualitative analyses will focus on system factors that may facilitate or hinder the implementation of the self-management approach within Veterans Health Administration (VHA).

PI_NAMEs: JALAL, DIANA I (contact)

PROJECT_TERMS: Address;Adherence;Affect;Albuminuria;Ambulatory Care;Appointment;arm;Blood Pressure;blood pressure control;blood pressure medication;blood pressure reduction;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care systems;Caring;Characteristics;Chronic Disease;Chronic Kidney Failure;Cities;Clinic Visits;Clinical;Clinical Pharmacists;Clinical Trials;Complex;Consolidated Framework for Implementation Research;Data;design;Dialysis procedure;Disease Progression;End stage renal failure;Evaluation;Exercise;experience;Feasibility Studies;Funding;General Population;Goals;health care delivery;health care model;Health Care Surveys;Healthcare Systems;high risk;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;implementation evaluation;implementation facilitation;implementation framework;improved;innovation;Instruction;Intervention;Interview;Iowa;Kidney Diseases;Learning;Licensing;Measurement;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;novel;novel strategies;Outcome;Outpatients;Participant;patient engagement;Patients;Performance;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Prevalence;primary care provider;primary outcome;programs;Provider;Quality of Care;Randomized;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Sampling;Self Management;Service delivery model;Services;shared decision making;standard care;Standardization;Structure;System;team-based care;Testing;Time;Titrations;tool;traditional care;United Kingdom;United States National Institutes of Health;Universities;Veterans;Veterans Health Administration

PROJECT_TITLE: Pharmacist-guided, patient-driven management of high blood pressure in CKD: A Novel Approach


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Narrative Plant-derived compounds (PDCs) such as gingerol from ginger, allicin from garlic, and carvacrol from oregano can improve bone disorders' healing. This follow-up application's objective is focused on mechanistic understanding of osteogenesis and angiogenesis behaviors of doped HA coatings along with PDCs. Our design goals are to improve bioactivity, introduce osteoinductivity to minimize healing time, and enhance interfacial mechanical properties between the HA coating and the implant to increase the coating in vivo lifetime. This program's scientific understanding will lead to improved long-term fixation of cementless joint replacements and minimize aseptic loosening.

PI_NAMEs: BOSE, SUSMITA  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Address;allicin;angiogenesis;Anti-Bacterial Agents;Beds;Behavior;Biocompatible Coated Materials;Biological;biomaterial compatibility;bone;bone cell;Bone Density;Bone Diseases;Bone remodeling;Bone Tissue;Cell Differentiation process;Ceramics;Chemistry;Coculture Techniques;Data;Defect;design;Distal;Failure;Femur;follow-up;Garlic;Gene Expression;Ginger;Ginger extract;Goals;Growth;HA coating;healing;Human;Hydroxyapatites;Implant;implant coating;improved;In Vitro;in vivo;interfacial;Kinetics;Knowledge;Lasers;Magnesium;Measures;mechanical properties;Mechanics;Metals;migration;Modeling;Modification;Operative Surgical Procedures;Oregano spice;Oryctolagus cuniculus;Osseointegration;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Outcome Measure;Oxides;parenting intervention;Parents;Patients;Phase;Phytochemical;Plasma;Polymer Chemistry;Process;programs;protein expression;Rattus;Replacement Arthroplasty;Research;response;sample fixation;Sample Size;Second Look Surgery;Silicon;Structure;success;Surface;surface coating;System;Time;Tissues;TNFSF11 gene;United States;Vascular Endothelial Growth Factors;Zinc

PROJECT_TITLE: Surface Modified Metal Implant Using doped Hydroxyapatite

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Persons with spinal cord injury have paralysis of the muscles necessary to cough and therefore have a high incidence of respiratory tract infections and secondary high mortality. Lower thoracic spinal cord stimulation has been shown to restore an effective cough and improve life quality in these individuals. We plan to develop an electrical stimulation system to restore an effective cough and test this device in a multi- center clinical trial leading to FDA approval and eventual world-wide availability.

PI_NAMEs: DIMARCO, ANTHONY F. (contact);MARTINS, TONY

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Air Movements;Amendment;Animals;Atelectasis;biomaterial compatibility;Bluetooth;Caregiver support;Caring;Cause of Death;CD2 gene;Cervical;Characteristics;Chest;Clinical;Clinical Trials;commercialization;cost effective;Coughing;Data;Development;Devices;Disease;Distal;Dorsal;Electric Stimulation;Electrodes;England;expiration;flexibility;Food and Drug Administration Device Approval;Generations;Hemorrhage;Implant;improved;Incidence;Indiana;Individual;Infection;Injury;Lead;Licensing;London;manufacture;Methods;minimally invasive;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;Muscle;neuromuscular system;Neurostimulation procedures of spinal cord tissue;Operative Surgical Procedures;Pain management;Paralysed;Participant;Pathway interactions;patient population;Patients;Persons;Positioning Attribute;positive airway pressure;Predictive Value;pressure;Quality of life;radio frequency;Recurrence;Reproducibility;respiratory;Respiratory Disease;Respiratory Tract Infections;Risk;Safety;Services;Site;Spinal;Spinal Cord;Spinal cord injury;Sterilization;Stimulus;Surface;Surgical incisions;System;Techniques;Testing;Thoracic spinal cord structure;Time;tool;user-friendly;Ventral Roots;virtual

PROJECT_TITLE: Multi-Center Clinical Trial of Spinal Cord Stimulation to Restore Cough

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Pediatric;Prevention

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

PHR: Project Narrative Impaired awareness of hypoglycemia affects one in four adults with type 1 diabetes and prevents them from achieving optimal blood sugar levels to protect them from the long-term complications of diabetes. It also increases the risk of severe hypoglycemia, which can cause loss of consciousness, seizures, accidents and even death. This study will develop better ways to diagnose, classify, predict and treat impaired awareness of hypoglycemia, using the most advanced technologies available, in patients with type 1 diabetes.

PI_NAMEs: CASU, ANNA ;PRATLEY, RICHARD E (contact)

PROJECT_TERMS: Accidents;Address;Adult;Affect;American;arm;Artificial Intelligence;Attention;Awareness;Blood Glucose;Brain;brain morphology;Cerebrovascular Circulation;Cessation of life;Classification;Clinical;clinical practice;Clinical Research;clinical research site;Clinical Trials;Closure by clamp;cohort;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;design;Diabetes Mellitus;Diagnosis;Education;efficacy testing;Elderly;Enrollment;Epinephrine;Event;executive function;experience;Foundations;Frequencies;Functional Magnetic Resonance Imaging;glucose production;glycemic control;Goals;Heart Rate;Heterogeneity;high risk;Hormonal;human old age (65+);Hybrids;Hyperinsulinism;Hypoglycemia;Impaired cognition;Impairment;improved;Incidence;Individual;innovation;insight;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Islets of Langerhans Transplantation;Lesion;Machine Learning;macrovascular disease;Measures;Methods;Microvascular Dysfunction;non-diabetic;novel strategies;older adult;Pancreatic Polypeptide;Participant;Patient Self-Report;patient subsets;Patients;pharmacologic;Physiologic Monitoring;Physiological;Population;Population Heterogeneity;predicting response;Prevalence;prevent;Prevention;primary endpoint;primary outcome;programs;Pump;Quality of life;Randomized;recruit;Reporting;Research Institute;Research Personnel;research study;Resolution;respiratory;response;Rest;restoration;Risk;Risk Factors;Risk Reduction;satisfaction;Seizures;Self Perception;sensor;Severities;smartphone application;Structure;support network;Symptoms;System;Technology;Testing;Time;Training;Translational Research;transplant centers;Unconscious State;United States National Institutes of Health;wearable device;white matter;Work

PROJECT_TITLE: Advanced Insulin Delivery to Reduce Impaired Awareness of Hypoglycemia in a T1D Cohort (AIDRIAHT1C)


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Recurrent HG in patients with type 1 diabetes may lead to the potentially lethal condition of impaired awareness of HG (IAH) where the first sign of a low blood sugar is confusion or unconsciousness. The purpose of this project is to perform a randomized clinical trial where a 12-month intervention of HG avoidance education and use of a hybrid closed loop system for insulin infusion is compared to standard care (which includes HG avoidance education, insulin administration via regular pump or injections, and CGM usage) to learn which best restores awareness of hypoglycemia in these patients. Individual physiological and experiential factors will also be collected to determine which exposures and experiences modify the restoration of hypoglycemia awareness and a new diagnostic tool will be tested and validated against standard methodologies.

PI_NAMEs: SEAQUIST, ELIZABETH R. (contact)

PROJECT_TERMS: Address;Age;arm;Awareness;Beta Cell;Blood Glucose;C-Peptide;Caring;Categories;Cell Physiology;Characteristics;Clinical;clinical center;Closure by clamp;Confusion;Data;design;Devices;Diabetes Mellitus;diagnostic tool;Education;Enrollment;Epinephrine;experience;Feeling;follow-up;food quality;Future;Glucagon;glucose production;glycemic control;Glycosylated hemoglobin A;Gold;Heterogeneity;Hybrids;Hypoglycemia;Impairment;Individual;Injections;insight;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Investigation;Knowledge;Learning;Machine Learning;Measurement;Measures;Metabolic;Methodology;Minnesota;Moods;novel diagnostics;Participant;Pathogenesis;Patient Self-Report;Patients;Performance;Persons;Physical activity;Physiological;prevent;primary outcome;Protocols documentation;Pump;Questionnaires;randomized, clinical trials;recruit;Recurrence;Research;Research Personnel;Residual state;response;restoration;Risk;Sleep;standard care;Stress;Symptoms;System;Techniques;Testing;therapy design;treatment arm;Unconscious State;Universities

PROJECT_TITLE: University of Minnesota Clinical Center for the Restoration of Impaired Awareness of Hypoglycemia in Type 1 Diabetes


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hypoglycemia remains a major barrier to the achievement of adequate glycemic control for most individuals with type 1 diabetes. Moreover, a substantial portion of adults with type 1 diabetes experience life-threatening episodes of severe hypoglycemia, and those with long standing disease complicated by impaired awareness of hypoglycemia (IAH) share the greatest burden of problematic hypoglycemia and its related morbidity and mortality. The present proposal aims to determine whether counterregulatory responses to hypoglycemia can be restored in individuals with long standing type 1 diabetes and IAH using state-of-the-art interventions implemented by an adaptive randomized clinical trial design with outcomes related to measures of physiologic defense mechanisms against the development of low blood glucose, glycemic control derived from continuous glucose monitoring, and participant reported assessment of hypoglycemia problems.

PI_NAMEs: RICKELS, MICHAEL R (contact)

PROJECT_TERMS: Achievement;Adult;Age;Awareness;Blood Glucose;Carbohydrates;Clinical;clinical practice;Clinical Research;Clinical Trials Design;Closure by clamp;Continuous Glucose Monitor;counterregulation;Defect;Defense Mechanisms;Development;Diabetes Mellitus;Disease;Dose;Education;Epinephrine;Event;experience;Exposure to;Failure;falls;Generations;Glucagon;glucose disposal;glucose production;glycemic control;Hepatic;Heterogeneity;Hybrids;Hyperglycemia;Hyperinsulinism;Hypoglycemia;illness length;Impairment;improved;Individual;Ingestion;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intervention;Islets of Langerhans Transplantation;Life Experience;Measurement;Measures;Morbidity - disease rate;mortality;novel;Outcome;Pancreatic Polypeptide;Participant;Patient Self-Report;Peripheral;permissiveness;personalized approach;personalized intervention;pharmacologic;Pharmacology;Physiological;post-transplant;Questionnaires;Randomized;randomized, clinical trials;Recommendation;Reporting;Research Design;response;restoration;Risk;Sequential Multiple Assignment Randomized Trial;standard of care;Standardization;Symptoms;Syndrome;System;Technology;technology intervention;technology platform;Testing;theories;Therapeutic;Time;trial design;Work

PROJECT_TITLE: Restoring awareness of hypoglycemia in type 1 diabetes


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Roughly 1 out of 20 patients living with type 1 diabetes will experience an episode of severe, life-threatening low blood sugar each year. Currently, we do not have ways to identify the patients that are most likely to experience one of these episodes, and we do not have strategies to help reduce that risk. This proposal seeks to address these two large, unmet needs by using continuous glucose monitoring technology to identify the patients at highest risk, and then use up to date management with new insulin pump technologies (called “hybrid closed loop”) to determine if these tools can reduce that risk and keep patients safe.

PI_NAMEs: PETTUS, JEREMY H (contact)

PROJECT_TERMS: Address;Age;arm;Awareness;Blinded;Blood Glucose;C-Peptide;Caring;Clinical;clinical practice;Clinical Trials;Closure by clamp;cohort;Continuous Glucose Monitor;counterregulation;Data;Day Blindness;diabetes management;Diabetes Mellitus;Enrollment;Epinephrine;experience;follow-up;Glucose;Goals;Gold;Heterogeneity;high risk;Hormones;Hospitalization;Hour;Hybrids;Hyperinsulinism;Hypoglycemia;hypoglycemia unawareness;Impairment;improved;inclusion criteria;Individual;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Life;Methods;Modernization;novel;Outcome;Patients;Plasma;primary outcome;Questionnaires;Randomized;Research;Research Design;response;Risk;risk mitigation;Risk Reduction;safe patient;Safety;screening;standard of care;Symptoms;System;Technology;Testing;Time;tool

PROJECT_TITLE: Using technology to define and mitigate risk of impaired awareness of hypoglycemia in patients with type 1 diabetes


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: “Restoration of Impaired Awareness of Hypoglycemia U01 Consortium: University of Kentucky” Narrative For people with Type 1 Diabetes (T1D) who must use insulin daily to stay alive, hypoglycemia (low blood sugar) is the rate limiting step in their goals to appropriately control their blood sugar and avoid long-term diabetes complications. People with T1D often develop an inability to sense when their blood sugar is low (known as “impaired awareness of hypoglycemia”) that increases their risk for life-threatening episodes of severe hypoglycemia. This grant application seeks to establish a 10-site clinical consortium to determine if advanced diabetes care technology coupled with intensive hypoglycemia avoidance education will improve their awareness of hypoglycemia and thus decrease their risk for life-threatening low blood sugar events.

PI_NAMEs: FISHER, SIMON J (contact)

PROJECT_TERMS: Adult;Age;Applications Grants;Awareness;Blood Glucose;burden of illness;Caring;Clinical Research;clinical research site;Closure by clamp;Complications of Diabetes Mellitus;Continuous Glucose Monitor;counterregulation;Coupled;Development;Diabetes Mellitus;Education;Event;experience;Failure;follow-up;Frequencies;Glucose;Glycosylated hemoglobin A;Goals;Heterogeneity;Hormones;Hybrids;Hyperinsulinism;Hypoglycemia;Impairment;improved;Individual;Infrastructure;Institution;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Kentucky;Leadership;Life;Measurement;Measures;Metabolic;Methodology;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;Pathologic Processes;Patient Self-Report;Patients;Persons;Physiological;Play;Questionnaires;recruit;Recurrence;Research;Research Project Grants;response;restoration;Risk;Role;Rural;Severities;Site;Study Subject;Symptoms;System;Technology;Testing;Time;U-Series Cooperative Agreements;Universities


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LINCOLN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE (OVERALL) The Rural Drug Addiction Research (RDAR) Center brings together basic and applied scientists from neurosci- ence, cognition, simulation, epidemiology, psychology, and sociology to address the etiology, assessment, pre- vention, and treatment of substance use and misuse. In Phase 2, RDAR will enhance the success of investiga- tors competing for external funding and increase the Center’s thematic footprint regarding basic, clinical, trans- lational, and community research by supporting the scientific growth and career development of investigators and fostering interdisciplinary research to investigate substance use and health disparities in Nebraska and the Great Plains. Working with community, university, and IDeA-state partners, RDAR will engage with clinical, com- munity health, and policy sectors to address the challenges of substance use in rural and underserved popula- tions, setting the stage for national, evidence-based impact on this critical health issue and supporting the trans- lation of research into intervention.

PI_NAMEs: BEVINS, RICK A (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: addiction;Address;Advisory Committees;Aging;Area;Award;Basic Science;Behavior;Biology;Brain;career development;Centers of Research Excellence;Child;Clinical;Clinical Research;Cognition;cognitive neuroscience;Collaborations;college;Communication;Communities;community engagement;Community Health;community research;community setting;Complex;Coupled;COVID-19;Dedications;Development;Discipline;Disease;disorder risk;Drug usage;Drug user;Environment;Epidemiology;Etiology;evidence base;experience;Family;Fostering;Foundations;Funding;Future;Geography;Grant;Great Plains;Growth;Growth and Development function;Health;health disparity;health equity;Hospitals;human subject;Infrastructure;insight;Institution;Interdisciplinary Study;Intervention;investigator training;Leadership;Medical center;member;Mentors;Methods;Microscopic;minority health disparity;Mission;Molecular;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Nature;Nebraska;Neurosciences;novel;obesity prevention;Opioid;outreach;Overdose;Pathway Analysis;Pattern;Phase;Pilot Projects;Policies;Population Research;Positioning Attribute;Prevention;Process;Productivity;programs;Psychology;Public Health;Reaction;recruit;Research;research facility;Research Personnel;Research Support;resilience;Resource Development;Rhode Island;Rural;Rural Community;Rural drug addiction;Rural Population;rural setting;Sampling;Schools;science education;Scientist;Secure;Services;simulation;social;Social Network;Societies;Sociology;Strategic Planning;substance misuse;substance use;substance use treatment;success;Synapses;Technical Expertise;tenure track;therapy development;Translating;Translational Research;Underserved Population;United States;United States National Institutes of Health;Universities;Vermont;Vision;Work;Youth

PROJECT_TITLE: Rural Drug Addiction Research (RDAR) Center - Phase 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Award;Biology;Biomedical Research;Budgets;career development;Centers of Research Excellence;Clinical Research;Cognition;cohort;Collaborations;college;Communities;community setting;Complex;Data Collection;Development;Development Plans;Discipline;Drug usage;Ensure;Environment;Epidemiology;Etiology;Evaluation;Event;Faculty;Focus Groups;Fostering;Funding;Future;Geography;Goals;Grant;Growth;Growth and Development function;Health;health disparity;Health Sciences;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Interview;Investments;Lead;Leadership;Link;Measurable;member;Mentors;Microscopic;Mission;Nature;Nebraska;Neurosciences;organizational structure;Outcome;outreach;Participant;Phase;Pilot Projects;Policies;Positioning Attribute;Prevention;Process;programs;Psychology;Public Health;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Rural Community;Rural drug addiction;rural drug use;Rural Health;Rural Population;rural setting;Secure;simulation;skill acquisition;social;Societies;Sociology;Structure;substance use;substance use treatment;success;Surveys;Synapses;synergism;Teacher Professional Development;tenure track;training opportunity;Translational Research;Underserved Population;United States;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

PI_NAMEs: TYLER, KIMBERLY A (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Applications Grants;Area;base;biological research;Biomedical Research;Biometry;Cellular Phone;Centers of Research Excellence;Cognitive;cohort;Cohort Studies;Collaborations;community engaged approach;community engaged research;community engagement;community partners;community setting;Computer software;Consultations;cost effective;County;COVID-19;Data;Data Collection;design;Development;Discipline;Disparity;Drug user;Ecological momentary assessment;Ensure;epidemiologic data;epidemiology study;Etiology;experience;Funding;Goals;Grain;Grant;Health;Health behavior;health data;Health Disparities Research;health disparity;human subject;Improve Access;Infrastructure;innovation;Intervention Trial;Longitudinal cohort;member;Methods;mHealth;mhealth interventions;Mission;mobile computing;Mobile Health Application;Nebraska;novel;outreach;pandemic disease;Participant;participant retention;Pathway Analysis;Patient Recruitments;Pattern;peer;Phase;Pilot Projects;Population;Positioning Attribute;Prevention;programs;Public Health;Qualitative Methods;recruit;remote interaction;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Respondent;response;Rural;Rural drug addiction;Rural Population;Sampling;Services;smartphone application;Social Network;substance use;success;support network;Surveys;sustainable resource;System;Techniques;Testing;therapy design;Time;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Longitudinal Networks Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: CHAN, HAU  (contact)

PROJECT_TERMS: Artificial Intelligence;Behavior;Behavior Therapy;Behavioral;care costs;Childhood;cohort;Cohort Studies;Complex;Computer software;contagion;Data;Data Collection;design;Development;Drug usage;drug use behavior;Early Intervention;Ecological momentary assessment;Employment Status;experience;Foundations;Frequencies;Friends;Future;Generations;Goals;Harm Reduction;Health;Health Care Costs;in silico;Individual;innovation;Intervention;Link;Machine Learning;machine learning method;Methodology;mHealth;Mission;model building;model generalizability;Modeling;network models;novel;Outcome;outreach;overdose death;Participant;Pattern;pediatric trauma;peer;peer influence;peer networks;Performance;Persons;Pharmaceutical Preparations;Phase;Positioning Attribute;predictive modeling;prevent;Prevention;Process;Recording of previous events;Research;Resource Allocation;Resources;response;Risk;Risk Factors;Rural drug addiction;rural drug use;simulation;smartphone application;social interventions;Social Network;societal costs;Statistical Models;substance misuse;substance use;Substance Use Disorder;support network;Testing;Time;tool;trend analysis;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Modeling the Co-evolution of Substance Use behavior and peer Networks of risk/support (CoSUN)


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Pediatric;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: GORMLEY, MATTHEW JOSEPH (contact)

PROJECT_TERMS: Absenteeism at work;Adult;adverse outcome;Age Years;aged;alcohol use disorder;Attention deficit hyperactivity disorder;Behavior;career;Cellular Phone;cohort;college;community college;comorbidity;Computer software;cost;Data;Data Collection;design;Development;Diagnosis;diagnostic criteria;Direct Costs;disability;Ecological momentary assessment;Economic Burden;Education;effective intervention;Enrollment;Environment;experience;Facilities and Administrative Costs;Fees;First Year Experience;Frequencies;Future;Goals;High Prevalence;improved;Income;Individual;Injury;Institution;Intervention Studies;Interview;Knowledge;Legal;Literature;Location;Measures;meetings;Mentors;Methods;Mission;Outcome;Participant;Patient Self-Report;Pattern;peer;Phase;Population;Positioning Attribute;Predisposition;prevent;Property;protective factors;Publishing;recruit;reduced substance use;relative cost;Research;Risk;Risk Factors;Risk Taking;Rural drug addiction;smartphone application;social;Structure;Students;Subgroup;substance use;Substance Use Disorder;success;Testing;therapy development;Time;university student;Vocation;Work;young adult

PROJECT_TITLE: College Aged Substance Use in Educational Settings: Outcomes for Students with ADHD (CASE4ADHD)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

PI_NAMEs: LORENZ, TIERNEY KYLE AHROLD (contact)

PROJECT_TERMS: Acceleration;aged;Anxiety Disorders;Area;associated symptom;Automobile Driving;Bisexual;clinically significant;comorbidity;Complex;contextual factors;craving;Cross-Sectional Studies;Cues;Data;design;Development;Disparity;Exhibits;experience;Exposure to;Failure;follow up assessment;Frequencies;Goals;Grant;Heterosexuals;Individual;internalized stigma;Intervention;Link;Measures;Mediating;men;minority stress;Mission;Modeling;Mood Disorders;mood symptom;Moods;novel;Participant;Pathway Analysis;Pattern;perceived discrimination;Persons;Phase;Pilot Projects;pleasure;Positioning Attribute;prevent;Prevention;programs;Reaction;recruit;Reporting;Research;response;Rewards;Risk;Risk Factors;Rural drug addiction;Sampling;sex;Sex Orientation;sexual minority stress;sexual minority women;Stress;stress symptom;substance use;Substance Use Disorder;substance use prevention;successful intervention;Surveys;Symptoms;Testing;therapy design;Time;Woman;Women's prevalence;women's prevention;Work;young woman

PROJECT_TITLE: Reward Enhancement and Stress as Cues for Substance use (RESCUES)


ORG_STATE: MN

PHR: Project Narrative This project addresses the following public health concerns regarding neonatal seizures: 1) high morbidity rates (40-60%) of permanent disabilities such as cerebral palsy, global developmental delay and post neonatal epilepsy1, 2) knowledge gaps regarding optimal dosing of Levetiracetam for the treatment of neonatal seizures, and 3) critical barriers in developing advanced technology for highly sensitive and specific automated seizure detection algorithms. In the long term, the proposal’s contribution to the fundamental knowledge of neonatal seizure research will impact neurodevelopmental outcomes through refining neonatal seizure treatment (by seizure burden and side effect profile) and rapid detection (with associated rapid treatment) of neonatal seizures.

PI_NAMEs: GOLD, JEFFREY J;HAAS, RICHARD H;SHARPE, CYNTHIA ;WANG, SONYA GRACE (contact)

PROJECT_TITLE: NEOLEV3: A Phase IIb Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures of Mild to Moderate Severity IND-109622 (September 6, 2020)


PHR: The Fond du Lac Band of Lake Superior Chippewa Regional Research Institute (FDL-RRI) brings together research, education, and tribal research capacity building to apply what we know to contribute to national efforts to reduce health disparities, improve mental and physical health outcomes, and ultimately promote health and wellness among American Indians and Alaska Natives (AIAN). Our projects informed by AIAN key stakeholders and health researchers has the potential to increase the availability of high-quality AIAN health data through the implementation of innovative science that will ultimately lead to improved health and the reduction of health disparities among American Indian and Alaska Native populations.

PI_NAMEs: DUNLAP, JACOB  (contact)

PROJECT_TERMS: Accountability;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Chippewa;Collaborations;Communities;community clinic;community collaboration;community college;Data;Data Collection;data management;data repository;Development;Disease;Education;Educational process of instructing;Employment Opportunities;empowerment;Epidemiology;Ethics;experience;Faculty;Fond du Lac;Fond du Lac Tribal and Community College;Foundations;Future;Goals;Great Plains;Health;health care service;health data;Health Disparities Research;Health Promotion;Health Surveys;improved;Indigenous;innovation;instrument;Intervention;Knowledge;Lead;Measurement;Measures;Mental Health;Minnesota;minority health;Modeling;Native American community;Native American Research Center for Health;Outcome;physical conditioning;Policies;Prevention;Psychometrics;Reduce health disparities;Research;Research Ethics;Research Institute;Research Personnel;Research Project Grants;response;Science;Services;Site;Social Well-Being;Solid;Students;success;Surveillance Program;Time;tool;Training;tribal community;tribal health;Tribes;United States;Universities;Washington