NIH_SPENDING_CATS: Brain Disorders;Headaches;Lymphatic Research;Migraine;Osteoporosis;Pain Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE: This project uses powerful biochemistry, pharmacology, and structural biology techniques to reveal how calcitonin family peptide hormones bind to their receptors on the surface of cells and develop novel tools for studying the receptors. The hormones regulate bone remodeling, vascular tone, blood glucose, and food intake and the receptors are drug targets for diseases including osteoporosis, migraine headache, cardiovascular disorders, and diabetes and obesity. Our studies will facilitate the development of therapeutics targeting these receptors and reveal concepts that are broadly relevant for several areas of human health and disease because the receptors are members of the large GPCR family that regulates most aspects of physiology.

PI_NAMEs: PIOSZAK, AUGEN A (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;adrenomedullin;adrenomedullin receptor;Affect;Affinity;Agonist;amylin receptor;analog;antagonist;Area;base;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biosensor;Blood;Blood Glucose;Blood Vessels;Bone remodeling;Calcitonin;Calcitonin Gene-Related Peptide;Calcitonin Receptor;calcitonin receptor-like receptor;Calcitonin-Gene Related Peptide Receptor;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Cell surface;Cells;Chimera organism;Collaborations;Complex;Computational algorithm;Coupled;Coupling;Cyclic AMP;design;Detergents;Diabetes Mellitus;Disease;Dissociation;drug development;Drug Receptors;Drug Targeting;Eating;Electrophoretic Mobility Shift Assay;Event;Exhibits;Extracellular Domain;Family;Food Intake Regulation;Funding;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Hand;Health;Heterodimerization;Hormone Receptor;Hormones;Human;in vivo;insight;islet amyloid polypeptide;Kinetics;Knowledge;Ligand Binding;Lymphatic System;lymphatic vasculature;Mammalian Cell;Measures;Mediating;member;Membrane;Membrane Proteins;Methods;Migraine;Molecular;Molecular Conformation;molecular dynamics;novel;Obesity;Osteoporosis;Outcome;overexpression;Pathway interactions;peptide drug;peptide hormone;Peptide Signal Sequences;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiology;preference;Property;Ramp;RAMP1;RAMP3;receptor;receptor internalization;receptor-activity-modifying protein;Regulation;residence;Resolution;response;Role;Salmon;Signal Transduction;stem;structural biology;Structure;System;Techniques;Tertiary Protein Structure;Testing;Therapeutic;therapeutic development;therapeutic target;Time;tool;Transmembrane Domain;Variant;Vasodilation;X-Ray Crystallography

PROJECT_TITLE: RAMP-altered class B GPCR hormone binding and signaling

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative Social memory impairment is one of the most debilitating factors in autism spectrum disorder (ASD). Understanding the circuits, cell-types and synaptic plasticity relevant for social memory will provide tangible targets for therapeutics. The proposed study will advance our basic understanding of the mechanisms underlying social memory as well as investigate potential approaches to improve social memory deficits in ASD-associated mouse models.

PI_NAMEs: WU, XIAOTING  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: antagonist;Antipsychotic Agents;autism spectrum disorder;autism symptoms;Bathing;Biological Assay;cell type;Cells;Cognitive;Data;debilitating symptom;Development;Disease;Dorsal;Electrophysiology (science);Emotional;experimental study;Goals;hippocampal subregions;Hippocampus;Histocytochemistry;Immune;Immunohistochemistry;Impairment;improved;in vivo;Infusion procedures;innovation;interdisciplinary approach;Investigation;Knowledge;Link;Measures;Memory;memory acquisition;Memory impairment;model of autism spectrum disorder;Molecular;mouse model;Mus;Mutation;Neuromodulator;Neurons;neuroregulation;new technology;Optics;optogenetics;Outcome;Output;Oxytocin;Pharmaceutical Preparations;Phase;Play;Population;Property;Proteins;receptor;Regulation;Research;Role;Schizophrenia;Slice;social;Social Behavior;Social Controls;social deficits;Social Interaction;Synapses;Synaptic plasticity;SYNGAP1;targeted treatment;Testing;Therapeutic;translational framework;Translational Research;Vasopressins;Viral;Virus Integration

PROJECT_TITLE: The role of the septum in social memory


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This project will conduct a mixed method study to investigate neurocognitive pathways by which neighborhood- level structural racism (i.e., socioeconomic conditions, environmental health, and educational opportunities) impacts substance use during adolescence. Findings will inform policy and interventions focused on substance use prevention among adolescents, including among Latino/a/x and Black youth.

PI_NAMEs: GONZALEZ, MARYBEL ROBLEDO (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: access disparities;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Age;Alcohol consumption;Alcohols;Area;Black race;Brain;Cannabis;Censuses;Chronic;cognitive development;cohort;Cohort Effect;Communities;community advisory board;community engaged research;community intervention;comparative;Data;Data Set;Decision Making;Development;Disadvantaged;Discrimination;distress tolerance;Economic Conditions;Education;Environment;Environmental Health;Epidemiology;ethnic minority;Ethnic Origin;Exposure to;Food;Green space;health care availability;Health Food;high school;Housing;Individual;insight;Intervention;intervention program;Interview;Investigation;junior high school;Latina;Latino;Latinx;Lived experience;longitudinal dataset;marginalization;marginalized community;marginalized population;marijuana use;Measures;Mediating;Mediator;member;Methods;minority children;minority communities;neighborhood disadvantage;Neighborhoods;Neurocognition;Neurocognitive;neurocognitive test;Nicotine;nicotine use;novel;Outcome;Pathway interactions;Phase;Photography;Play;Policies;Policy Maker;Poverty;Prevalence;Prevention program;Process;Qualitative Methods;Race;racial discrimination;racial minority;reduced substance use;Regression Analysis;Resources;Risk;Risk Factors;Role;Sampling;skills;social health determinants;Societies;socioeconomics;Structural Racism;substance use;substance use prevention;System;Techniques;Testing;Toxin;United States;Youth

PROJECT_TITLE: A mixed-method study to investigate the impact of neighborhood-level structural racism on neurocognition and substance use in adolescence


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: RICHARDS, JENNIFER RAI (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;Accidents;active control group;addiction;Address;Adolescent;Adult;Age;aged;Alaska;Alaska Native;Alaska Native population;alcohol comorbidity;alcohol use disorder;Alcohols;Ally;American Indian Population;American Indians;Awareness;Biological Models;Caring;Child;Cognitive;Collaborations;commune;Communities;community research;coping;Coupled;Data;design;Diagnostic;Drug usage;Early Intervention;Ecosystem;Education;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness measure;Elements;Enrollment;Epidemic;Equity;Ethnic Population;evidence base;Evidence based intervention;experience;Fathers;Female;follow-up;Foundations;Funding;Gender;Health;health disparity;high risk;high risk population;Homicide;implementation strategy;improved;Indigenous;Inequity;Injury;innovation;Intervention;Knowledge;Leadership;male;Male Adolescents;Mediating;Mediator;men;Mental Health;Methods;Modification;Morbidity - disease rate;mortality;Mothers;National Institute of Drug Abuse;Navajo;neglect;Outcome;Participant;Pathway interactions;Pattern;perceived discrimination;personalized approach;prevent;Prevention;Prevention program;Prevention Research;Prevention strategy;primary outcome;Program Effectiveness;programs;protective factors;Public Health;racial population;Randomized, Controlled Trials;reduced substance use;Research;Research Methodology;Research Personnel;Research Project Grants;Resource-limited setting;Risk;Risk Factors;Rural;Rural Community;Science;Secondary Prevention;Self Efficacy;Services;skills;social determinants;Source;substance use;Substance Use Disorder;substance use prevention;synergism;Testing;Time;transition to adulthood;Trauma;treatment arm;trial design;Tribes;universal prevention;Violence;Woman;Work;young adult;young man

PROJECT_TITLE: Research Project 2


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Alzheimer’s disease (AD) and AD related dementias (ADRDs) are a major cause of disability and mortality in the United States, but there are no effective therapies to slow or reverse progressive cognitive deficits in these disorders. Moreover, we have an incomplete understanding of AD and ADRD due to insufficient recruitment and retention in understudied populations. The proposed program will add to our understanding of AD and ADRD through comprehensive social and biological assessments in understudied individuals, self-identifying as Hispanic/Latinx, Black, and Asian American/Pacific Islander in Los Angeles County.

PI_NAMEs: VOSSEL, KEITH ALAN (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian Americans;Awareness;Behavior Therapy;Behavioral;Biological;Biological Markers;biomedical referral center;Biometry;Black American;Black race;Blood;California;Caring;Clinical;Cognitive deficits;cohort;Communities;community engagement;community involvement;community organizations;community partners;community partnership;comorbidity;County;Data;data sharing;Dementia;design;Diagnosis;disability;Disease;Education and Outreach;effective therapy;Electronic Health Record;Eligibility Determination;endophenotype;Enrollment;Environmental Risk Factor;Epilepsy;Face;Funding;Future;Genetic;genetic risk factor;genomic data;Genomics;Goals;Health;Health system;Heterogeneity;Hispanic;improved;Individual;Infrastructure;innovation;insight;Japanese American;Latinx;Linguistics;Link;Los Angeles;member;Methods;mortality;multidisciplinary;multiple data types;Neurobiology;neuroimaging;neurophysiology;Pacific Islander;Participant;patient health information;Patient Recruitments;Patients;Pharmacological Treatment;Phase;polygenic risk score;Population;Population Heterogeneity;precision medicine;predictive modeling;Primary Care;primary care clinic;programs;recruit;Reduce health disparities;Request for Proposals;Research;Research Design;Research Infrastructure;Risk;Risk Factors;screening;Screening procedure;Site;social;social culture;social health determinants;Standardization;Syndrome;targeted treatment;tool;Trust;United States;Universities;Work

PROJECT_TITLE: Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles County


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The use of genomic data to aid diagnosis and therapeutic decisions requires electronic health records to store and manage complex genomic information. Existing technologies do not sufficiently support our current understanding of how genomics impacts health, however, so new methods must be developed. This research program will develop new approaches for managing clinical genomic information, thereby accelerating research that improves human health.

PI_NAMEs: FREIMUTH, ROBERT RICHARD (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Acceleration;Area;Automobile Driving;Award;Clinical;Clinical Management;clinical practice;Collaborations;Communities;Complex;Data;data sharing;Decision Making;Development;Diagnosis;Diagnostic;Electronic Health Record;genomic data;Genomic medicine;Genomics;Germ Lines;Health;Healthcare Systems;Human;improved;Information Management;Knowledge;knowledge integration;Knowledge Management;Learning;Life;Medical;Methods;Modeling;Modernization;Nature;novel strategies;Patients;precision medicine;Process;programs;rapid growth;Reporting;Research;Research Support;Resources;Science;Speed;Standardization;structured data;System;Technology;Testing;Therapeutic;Translating;Translations

PROJECT_TITLE: Integrated Knowledge Management Framework for Clinical Genomics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The proposed project will determine mechanisms that control -cell and -cell Na+/K+-ATPase activity and how they regulate Ca2+ handling as well as islet hormone secretion. Results from this project are also expected to provide significant mechanistic insights into disruption of islet Ca2+ handling and hormone secretion in T2D in the context of perturbed glucose control and GPCR regulation of Na+/K+-ATPase function. Thus, the proposed research project will generate fundamental knowledge about human islet function and dysfunction that will help reduce the burden of human illness in the context of diabetes.

PI_NAMEs: JACOBSON, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Animal Disease Models;Beta Cell;blood glucose regulation;Cell membrane;Cell Physiology;Cells;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;cytokine;D Cells;Data;Data Set;Diabetes Mellitus;diabetes pathogenesis;diabetic;diabetogenic;Exposure to;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression;Genes;Glucose;glycemic control;Goals;Health;High Fat Diet;Homeostasis;Hormone secretion;Human;Inflammation;inhibitor;insight;Insulin;Insulin Receptor;insulin receptor tyrosine kinase;Insulin Resistance;insulin secretion;insulin signaling;Ion Channel;islet;Islet Cell;Islets of Langerhans;K ATPase;knock-down;Knowledge;Laboratory Finding;Mediating;Membrane Potentials;Metabolic stress;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Paracrine Communication;Pathway interactions;Patients;pharmacologic;Phosphorylation;Physiological;protein complex;Protein Tyrosine Kinase;Proteins;Pump;Reactive Oxygen Species;receptor;Receptor Inhibition;Receptor Signaling;Regulation;Research Project Grants;response;Role;Signal Transduction;Somatostatin;src-Family Kinases;Stress;Testing;therapeutic target;Time;Tissues;transcriptome sequencing;Transgenic Mice;type I and type II diabetes;voltage;Work

PROJECT_TITLE: Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Precision Medicine;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: Project Narrative Short-term mortality prediction is critical to optimizing healthcare quality for hospitalized older adults by identifying which patients are most likely to benefit from which healthcare services (e.g. hospice) and medications (e.g. statins). Unfortunately, we lack high-quality validated prediction tools to help clinicians determine short term mortality risk. The objective of this project is to create prediction tools for estimating short term mortality risk for hospitalized older adults with and without Alzheimer’s disease and related dementias.

PI_NAMEs: LEE, SEI  (contact);SMITH, ALEXANDER KELIIMOEANU

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acute care;Age;Alzheimer's disease related dementia;Anti-Hypertensive Agents;Chronic;Clinic;clinical decision-making;clinical diagnosis;cohort;collaboratory;Communities;Conscious;Data;Data Element;Delirium;design;Development;Effectiveness;effectiveness validation;Elderly;Electronic Health Record;Eligibility Determination;end of life;Ensure;Equity;Exclusion;experience;functional status;health care quality;health care service;Health Services;Healthcare Systems;high risk;Hospice Care;hospice environment;Hospitalization;Hospitals;improved;indexing;innovation;Israel;Laboratories;Length of Stay;Life;Lipids;Measures;Medical center;Methodology;Methods;model building;Modeling;mortality;mortality risk;neighborhood disadvantage;nonalzheimer dementia;older adult;online resource;Online Systems;outcome prediction;Outpatients;Palliative Care;patient prognosis;Patients;personalized predictions;Persons;Pharmaceutical Preparations;Physical Function;Physiological;Positioning Attribute;predictive modeling;predictive tools;Prognosis;prognostic index;prognostic model;prognostic value;Publications;Qualifying;Research;Role;Site;social health determinants;Standardization;System;Techniques;Validation;Work

PROJECT_TITLE: Prognostic Indices for Hospitalized Older Adults with and without Alzheimer’s Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: ALLEN, SEAN T (contact)

PROJECT_TERMS: Abstinence;Affect;Alaska Native;Ally;American Indians;Attitude;Belief;Client;Communicable Diseases;Communities;community based participatory approach;community based participatory research;Data;Drug usage;Drug user;Emotional;Equipment;Equity;Ethnic Population;evidence base;Funding;Goals;Harm Reduction;healing;Health;health inequalities;Healthcare;HIV;HIV diagnosis;implementation facilitation;implementation process;Indigenous;indigenous community;Inequity;Infection;informant;Injecting drug user;injection drug use;Injections;innovation;Intervention;Interview;Knowledge;Leadership;Legal;Life Expectancy;medication for opioid use disorder;member;Mental Health;Methods;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Nature;Needle Sharing;Needle-Exchange Programs;opioid misuse;Outcome;Overdose;Pattern;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;prescription opioid misuse;Prevalence;Primary Care;programs;Public Health;Racial Equity;racial population;Reporting;Research;Research Personnel;Research Project Grants;Role;service programs;service utilization;Site;social;social factors;social stigma;sociocultural determinant;sociodemographic group;Spirituality;Sterility;structural determinants;substance use;substance use treatment;Tribes;United States;Viral hepatitis

PROJECT_TITLE: Research Project 3


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE High blood pressure can lead to heart attacks, strokes, and kidney failure, amongst other outcomes, but lowering blood pressure too much leads to bad outcomes. This study will help understand how more information about certain people, especially those with multiple chronic conditions and older adults, can help balance the risks and benefits.

PI_NAMEs: DORR, DAVID A. (contact);SAMAL, LIPIKA

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;adjudication;Adverse event;adverse event risk;adverse outcome;American;Award;Benefits and Risks;Blood Pressure;blood pressure control;Caring;Chronic;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Research;Clinical Trials;cognitive function;Collaborations;collaborative approach;Data;data harmonization;data integration;Data Set;Data Sources;Decision Making;Effectiveness of Interventions;electronic data;Electronic Health Record;Electronics;Equilibrium;Evaluation;FAIR principles;falls;Fast Healthcare Interoperability Resources;Goals;Guidelines;Health behavior and outcomes;health record;Hypertension;hypertension control;Hypotension;improved;Infrastructure;Institution;interoperability;Journals;Kidney Failure;Measurement;Measures;Medical Informatics;Methods;Modeling;multiple chronic conditions;multiple data sources;Myocardial Infarction;Natural Language Processing;New York;older adult;optical character recognition;Outcome;Outcome Measure;Outcome Study;Paper;Participant;participant enrollment;patient engagement;patient prognosis;Patient-Centered Care;Patient-Focused Outcomes;Patients;personalized decision;Persons;Population;preference;Primary Care;Process;Provider;Readiness;Research;Research Personnel;Resources;Scanning;Site;social health determinants;Stroke;symposium;Techniques;Text;tool;usability;Work

PROJECT_TITLE: Multiple Chronic COnditions: MultiPle dAta SouRcEs (MC COMPARE)


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: The proposed software will improve the quality of genomic datasets by empowering individual researchers to contribute their own annotations, as well as putting more sophisticated tools in the hands of expert biocurators, allowing them to simultaneously annotate multiple phylogenetically related organisms at once. It will also collect data from biocurators en masse to help train machine learning systems for AI-assisted genome annotation.

PI_NAMEs: HOLMES, IAN H (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;annotation  system;Artificial Intelligence;cloud based;Code;Collaborations;Communities;community engagement;comparative;comparative genomics;Computer software;computerized tools;crowdsourcing;Custom;Data;design;Detection;Documentation;Education;Educational workshop;empowerment;Event;experience;gene function;Generations;Genes;Genome;genome annotation;genome editing;genome resource;genome sequencing;genomic data;Genomic DNA;Genomics;improved;indexing;Individual;Infrastructure;innovation;interest;Internet;Location;Machine Learning;Maintenance;Manuals;Maps;Methods;Modernization;next generation;Ontology;operation;Organism;outreach;Parasites;Performance;Phylogenetic Analysis;Plug-in;Population;Productivity;protein structure;Quality Control;Recommendation;Research;Research Personnel;scale up;Security;Sequence Homology;Side;Source;Structural Genes;Structure;symposium;Synteny;System;Testing;tool;Training;usability;Validation;Variant;volunteer;web app;web services;WormBase;Writing

PROJECT_TITLE: Developing the Apollo software for high-throughput annotation of multiple genomes

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE To develop Real-World Data (RWD) and Real-World Evidence (RWE) of the broad activity and benefit to society from new therapies approved by the FDA, we propose a collaborative research project to be funded under the U01 mechanism to implement novel approaches to this research. We suggest a more longitudinal approach to real-world data acquisition, starting during Phase III trial testing and feeding into a more rigorous and diverse approach to Phase IV confirmation. We will partner with Optum Life Sciences to facilitate identification of patients, especially those with rare tumors and uncommon molecular subgroups, and to build relevant cohorts to interpret community-wide treatment results.

PI_NAMEs: BENSON, AL B;COLE, SUZANNE MARIE;ODWYER, PETER J (contact);WANG, XIN VICTORIA

PROGRAM_OFFICER_NAME: LAUDA, MARK

PROJECT_TITLE: Real-World Data to Generate Real-World Evidence in Regulatory Decision-Making


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: WASHINGTON

ORG_NAME: EDVOTEK, INC.

ORG_STATE: DC

PHR: Project Narrative Mastery of quantitative biology skills, through training in mathematics and statistics in high school and undergraduate laboratory courses, is crucial for the successful preparation of students for contemporary STEM careers. To address this need, we propose the continued development of the EdvoReader platform, a quantitative biology framework that combines a user-friendly instrument, a collection of hands-on educational experiments, and a citizen science curriculum to guide students through data collection and analysis. Importantly, experimentation using this platform will introduce students to quantitative polymerase chain reaction (qPCR) and colorimetry, essential laboratory techniques that have become a cornerstone of disease detection, environmental monitoring, and biotechnology research.

PI_NAMEs: ELL, BRIAN  (contact);SNOWFLACK, DANIELLE

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Awareness;Biochemistry;Biological;Biological Assay;Biological Sciences;Biology;Biotechnology;career;career awareness;career development;Career Exploration;citizen science;Collection;Colorimetry;commercialization;Communities;community science;Complement;cost;Data;Data Analyses;Data Collection;Data Display;data sharing;Dedications;design;Detection;detection assay;detection platform;Development;Device Designs;Disease;Education;education resources;educational atmosphere;Educational Curriculum;Educational process of instructing;Enterococcus;Environmental Health;Environmental Monitoring;Environmental Protection;Environmental Science;Equipment;experimental study;Face;Focus Groups;Funding;Goals;Health protection;Heavy Metals;high school;High School Student;Human;improved;instructor;instrument;Intuition;Laboratories;laboratory curriculum;Learning;Length;Libraries;Life;materials science;mathematical analysis;Mathematics;Measurement;Modeling;Modernization;operation;Optics;Pathway interactions;Phase;Play;Polymerase Chain Reaction;Preparation;Printing;Protocols documentation;prototype;recruit;Regulation;Research;Research Design;Resources;Sampling;Science;science teacher;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Series;simulation;skills;skills training;Small Business Innovation Research Grant;statistics;STEM career;Students;success;Surveys;System;teaching laboratory;Techniques;Technology;Testing;Time;touchscreen;Training;undergraduate student;United States Environmental Protection Agency;user-friendly;water quality

PROJECT_TITLE: The EdvoReader: Developing a Quantitative PCR and Colorimetry Instrument for Laboratory Skills Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SCIL-D(10)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Obesity-associated disease of the liver is a common and significant condition in the Mexican American Community. This study seeks to identify possible genes and their related elements that are associated with susceptibility and progression of liver disease in participants randomly chosen from the CCHC. We anticipate this could lead to identifying targets for intervention in this condition as well as identifying elements we could use for identifying those at high risk before they develop significant liver disease.

PI_NAMEs: BELOW, JENNIFER ;MCCORMICK, JOSEPH  (contact);NORTH, KARI E.

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Abdomen;Address;Adipose tissue;Adult;Affect;Biological;Biological Markers;biomarker discovery;Biopsy;Blood specimen;cardiometabolic risk;chronic liver disease;cohort;Collaborations;Collection;Communities;Consent;County;Data;Data Analyses;Data Collection;data integration;data sharing;design;Development;Disease;Disease Progression;elastography;Elements;Enrollment;Environmental Exposure;Equation;experience;Fatty acid glycerol esters;Fibrosis;follow-up;Future;Generations;Genes;Genetic;global health;Health;high risk;Hispanic;Hispanic Populations;human disease;Individual;Infrastructure;Intervention;Latino;Latino Population;Leadership;Liver;Liver diseases;Liver Fibrosis;Longitudinal cohort;Longitudinal Studies;Measures;Mediation;Mendelian randomization;Metabolic;Metabolic dysfunction;metabolic-associated fatty liver disease;metabolomics;Mexican Americans;Modeling;Molecular;Molecular Profiling;multidimensional data;multiple omics;non-alcoholic fatty liver;nonalcoholic steatohepatitis;novel;Obesity associated liver disease;Participant;Pathogenesis;Pharmacotherapy;Phenotype;phenotypic data;Population;Population Heterogeneity;Population Study;Predisposition;preservation;Prevalence;Production;prospective;Proteomics;Research;response;Risk Factors;Science;Signal Transduction;Site;social health determinants;Specimen;subcutaneous;Technology;Time;Tissues;transcriptomics;United States National Institutes of Health;Visit;Vulnerable Populations;Whole Blood;Work

PROJECT_TITLE: Multi-omics for obesity-associated liver disease discovery in Hispanics/Latinos: the Cameron County Hispanic Cohort


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Endocrine Disruptors;Estrogen;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This study will evaluate how everyday chemicals found throughout our environment – in food packaging, medication coating, and plastics – affect mood and cognition in middle and older age women. It will also drill down to identify the biological mechanisms by which these chemicals exert their effects, exploring multiple pathways including via inflammation, sex hormones, and a brain growth factor. Understanding biological mechanisms in depression and cognitive decline is critical to developing new targets for treatment, and knowledge of the role of endocrine-disrupting chemicals in such symptoms in later life is vital to the public health, because while exposure is nearly ubiquitous, lifestyle changes can reduce such chemical exposures and may alter disease trajectories.

PI_NAMEs: HARDER, JESSICA ANN (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adverse effects;Affect;affective disturbance;Age;Animal Model;Awareness;Behavior;Biological;Biological Markers;Biological Process;Biometry;Brain;Brain-Derived Neurotrophic Factor;C-reactive protein;career development;chemical association;Chemical Exposure;Chemicals;Child;Childhood;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Collaborations;Competence;consumer product;cytokine;Data;Data Collection;depressive symptoms;Development Plans;Dimensions;Disease;disorder risk;early life exposure;Educational workshop;Emotional;Endocrine Disruptors;Environment;Environmental Exposure;Environmental Impact;Environmental Pollutants;Estradiol;Estrogens;experience;Exposure to;Female;Food Packaging;Foundations;Genes;Goals;Gonadal Steroid Hormones;Grant;Growth Factor;Health;Hormonal;Hormones;human old age (65+);Impaired cognition;Individual;Inflammation;Inflammatory;inflammatory marker;interest;Interleukin-6;Intervention;Knowledge;laboratory experience;late life;Life;Life Style;lifestyle intervention;Literature;Major Depressive Disorder;Measures;Mediating;Mediation;Mediator;Menopause;Mental Depression;Mentorship;Methods;Methylation;middle age;Mood Disorders;mood symptom;Moods;neurobehavioral;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;neurotrophic factor;neurotropic;novel;older women;Outcome;Outcome Measure;Pathway interactions;Patients;Pharmaceutical Preparations;phthalates;Plastics;Postmenopause;pre-clinical;Predisposition;prenatal;primary outcome;profiles in patients;programs;Public Health;Public Policy;Qualifying;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Series;Serum;Severities;sex variable;Standardization;Statistical Methods;symposium;symptomatology;Symptoms;Synaptic plasticity;Testing;Testosterone;Therapeutic Intervention;TNF gene;Training;urinary;Urine;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Understanding the Relationship Between Environmental Endocrine Disrupting Chemicals, Neuropsychiatric Outcomes, and Related Biological Processes in Depression


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative It is predicted that 16% of the world’s population will be older than 65 years by 2050. The proposed research project will develop new methods to assess the brain metabolism across the healthy lifespan. These techniques will contribute to our understanding of healthy aging and its link to cognitive performance, may identify biomarkers for healthy aging, and may lead to earlier identification of subject-specific abnormalities associated with a higher risk of age-related disease.

PI_NAMEs: ZOELLNER, HELGE JOERN (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;Age;age related changes;Age Years;age-related disease;Aging;Algorithms;Alzheimer's disease related dementia;Biochemical;Biochemistry;Biological Markers;Biological Process;biomarker identification;Biophysical Process;brain metabolism;candidate marker;career;career development;Choline;Clinical;Clinical Research;cognitive performance;cohort;Communities;Computer software;Consensus;Consumption;Coupled;Creatine;Data;Data Analyses;density;design;Development;Diagnostic;Dictionary;early detection biomarkers;Early identification;Early Intervention;Environment;Evolution;experimental study;Exposure to;Female;Fingerprint;Foundations;Generations;Glutamates;Goals;Grant;healthspan;healthy aging;healthy volunteer;high risk;human old age (65+);improved;in vivo;Individual;innovation;Knowledge;Learning;Life;Life Expectancy;life span;Link;Lipids;Literature;macromolecule;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measurement;Measures;Medicine;Mentors;Methodology;Methods;Modeling;Molecular;myoinositol;N-acetylaspartate;Neurobiology;neurochemistry;Neurodegenerative Disorders;Neurons;next generation;normal aging;North America;novel;novel marker;open source;Paper;Participant;Pattern;Physiologic pulse;Population;preventive intervention;Process;Protons;Recovery;Relaxation;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resolution;Resource Development;Risk;Role;Schedule;Sequence Analysis;Side;Signal Transduction;Societies;Source;Specificity;Structure;Techniques;Testing;Time;Training;training opportunity;Universities;volunteer;Water

PROJECT_TITLE: Brain metabolism across the lifespan using multi-parametric MRS

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE The hypothalamus plays a fundamental role in whole-body aging, but the underlying basis and the interventional value remain to be established; thus, this project is to study the aging relevance and anti- neurodegenerative actions as well as the therapeutic significance of hypothalamic extracellular vesicles. Overall, the study represents a major milestone for developing an important strategy and target for aging- associated health problems and especially neurodegeneration and related diseases.

PI_NAMEs: CAI, DONGSHENG  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: age acceleration;age related;age related neurodegeneration;Aging;aging brain;aging related;Animals;anti aging;Area;Autonomic nervous system;Biochemical;Biological Process;Brain;Cell secretion;cell type;Cells;Cognition Disorders;Communication;Data;Disease;Distant;DNA Damage;Effectiveness;Endocrine;Endocrine system;Equilibrium;Event;Experimental Models;experimental study;extracellular vesicles;Formulation;Funding;Generations;Genetic;genetic manipulation;Health;healthspan;healthy aging;Homeostasis;Hormonal;Hypothalamic structure;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Inflammatory;Intervention;Knockout Mice;Knowledge;life span;Longevity;Maintenance;Metabolic;Metabolism;Methods;Modeling;Molecular;mouse model;Nerve Degeneration;nerve stem cell;neural;Neurodegenerative Disorders;neurodegenerative phenotype;Neurons;neuroprotection;Neurosecretory Systems;normal aging;novel;novel strategies;old mice;pharmacologic;Physiological;Physiology;Play;pro-aging;programs;Publications;Publishing;Research;Role;senescence;Signal Transduction;Site;Small Nuclear RNA;stem cells;Therapeutic;Therapeutic Effect;tissue degeneration;uptake;Vesicle

PROJECT_TITLE: The Hypothalamic Basis of Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: RFA-HL-23-019 RMIP II-Collaborative U01. Contact PI - Gary Yam Project Narrative Millions of people suffer from corneal blindness and a low percentage of them (an estimated rate of 1 in 70) are treated by donor cornea transplantation, with limited success due to various issues like post-operative complications, graft rejection, and scarcity of donor corneas worldwide. Our team has discovered corneal stromal stem cells that can effectively reduce corneal scarring in animal models. This project aims to establish procedures to generate Good Manufacturing Practice stem cells, and confirm their safety and efficacy, leading to future clinical trials.

PI_NAMEs: SIKDER, DEVANJAN ;YAM, HIN FAI  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: absorption;Advisory Committees;Affect;Allografting;Animal Model;Animals;Anti-Inflammatory Agents;Behavior;Biological Assay;Blindness;Cancer Center;Cell Therapy;Cells;Characteristics;Chemistry;Cicatrix;Clinic;clinical application;Clinical Data;Clinical Protocols;Clinical Treatment;clinical trial readiness;Clinical Trials;Clinical Trials Design;clinically relevant;Cornea;corneal allograft;Corneal Injury;Corneal Opacity;corneal regeneration;corneal scar;Cryopreservation;Cyclic GMP;dashboard;Data;Data Analyses;Data Analytics;data mining;Databases;design;digital;Disease;Documentation;efficacy testing;electronic health data;Eligibility Determination;Environment;Etiology;Excretory function;experience;eye center;Foundations;Future;Goals;Good Manufacturing Process;Graft Rejection;healing;Human;Immunologic Monitoring;in vivo;indexing;innovation;Investigation;Investigational Drugs;Joints;Keratitis;Keratoplasty;Laboratories;Manuals;manufacture;Medical center;Metabolism;Modeling;Monitor;mouse model;Multivariate Analysis;Mus;Natural regeneration;novel therapeutics;Operative Surgical Procedures;ophthalmic examination;Ophthalmology;Outcome;patient health information;Patients;Persons;pharmacologic;Pharmacology and Toxicology;Phase;Postoperative Complications;Preparation;prevent;Procedures;Production;programs;Protocols documentation;Qualifying;quality assurance;Quality Control;regenerative;Rehabilitation therapy;response;Route;Running;Safety;safety testing;scale up;Solid;stem cell based approach;stem cell therapy;stem cells;stemness;stromal progenitor;success;System;Testing;Tissues;Topical application;Toxic effect;Toxicology;Translating;translational study;Transplantation;Treatment Efficacy;Treatment outcome;Tumorigenicity;Universities;Visit;Visual;Visual Acuity;visual performance;welfare;Work;Wound models;Yam - dietary

PROJECT_TITLE: Cell Therapy Program with Scale-up cGMP Manufacturing of Human Corneal Stromal Stem Cells


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative The use of Big Data analytics or data science in healthcare has already presented promising results for the generation of value for all healthcare stakeholders in several contexts. However, more technological, organizational, multidisciplinary, and collaborative connectivity among stakeholders from academia, government and industry is critical to realizing the full potential of data science in healthcare. The proposed conference will stimulate further advancements in Big Data health science research through rich interdisciplinary and multidisciplinary collaboration and promote NIH’s Strategic Plan for Data Science.

PI_NAMEs: LI, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Academia;Academic Training;Address;Aging;analytical tool;Area;authority;Big Data;Big Data Methods;biomedical data science;Case Manager;climate change;Communication;community engagement;Complex;Computer software;cost;COVID-19;Data;data infrastructure;data management;data resource;Data Science;Data Scientist;Development;Disease;Disease Outbreaks;disorder prevention;Ecosystem;Educational workshop;Ensure;Event;experience;Funding;Future;Generations;global health;Goals;Government;Growth;Health;health disparity;health practice;health science research;Health Sciences;Healthcare;Healthcare Industry;Healthcare Systems;Human;improved;Industry;innovation;Institution;Interdisciplinary Study;Investments;Knowledge;leadership development;Legal;Mentors;Methodology;Methods;minority investigator;Mission;Modernization;multidisciplinary;next generation;novel strategies;Output;Patients;Pattern;Pharmacologic Substance;Policies;Policy Maker;Politics;Population;Provider;Publications;Published Comment;Publishing;Request for Applications;Research;Research Personnel;Scientific Advances and Accomplishments;Series;Shapes;skills;Source;South Carolina;Strategic Planning;Students;success;symposium;System;Talents;Technology;tool;Training;United States National Institutes of Health;United States National Library of Medicine;Universities;Visualization software;Workforce Development

PROJECT_TITLE: University of South Carolina Big Data Health Science Conference


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Gene Therapy;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Hypertrophic cardiomyopathy (HCM) is a common genetic heart condition that causes sudden cardiac death and congestive heart failure, and for which current treatments do not slow or prevent progression of the condition. The gene that is most commonly mutated in HCM is called myosin binding protein C. The goals of this study are to understand how mutations in myosin binding protein C affect how the protein associates with other binding partners, and whether these effects can be reversed therapeutically by delivery of the normal protein using gene therapy.

PI_NAMEs: DAY, SHARLENE M (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: adeno-associated viral vector;Affect;Alleles;Arrhythmia;Binding;Binding Proteins;Biological Assay;Biological Process;Biology;Cardiac Myocytes;Chimeric Proteins;Clinical Trials;Complement;Complex;Congestive Heart Failure;Cytoskeleton;Data;delivery vehicle;Disease;Disease Pathway;DNA Sequence Alteration;Dose;Echocardiography;Electrostatics;Eligibility Determination;experience;experimental study;Familial Hypertrophic Cardiomyopathy;Gene Delivery;gene replacement;gene replacement therapy;gene therapy;Genes;Genetic;genetic variant;Goals;Heart;Heart failure;Heterozygote;Human;Hypertrophic Cardiomyopathy;improved;in vivo;induced pluripotent stem cell;insight;Knock-in Mouse;Label;Laboratories;Lead;Lentivirus Vector;loss of function;Mass Spectrum Analysis;Measures;Mediating;Missense Mutation;Molecular Chaperones;Molecular Conformation;mouse model;mutant;Mutate;Mutation;Myocardium;Myofibrils;Myosin ATPase;myosin-binding protein C;Neighborhoods;novel;Outcome Measure;Pathogenicity;Patients;prevent;primary outcome;protein degradation;protein protein interaction;Proteins;Proteomics;Publishing;Reagent;Regulation;Relaxation;Research Personnel;response;Ribonucleoproteins;Ribosomes;Sarcomeres;secondary outcome;skills;stoichiometry;success;sudden cardiac death;Surface Properties;Tacrolimus Binding Protein 1A;Talents;Techniques;Tertiary Protein Structure;Testing;Therapeutic;Translations;Treatment Efficacy;Variant;Viral Vector

PROJECT_TITLE: Missense Variants in Myosin Binding Protein C that Cause Hypertrophic Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Mechanical interactions and signals provide the basis for numerous physiological processes including allowing cells to move and form multicellular structures. Misregulation of these mechanical signals has been implicated in a broad array of diseases and developmental impairments. This project investigates novel mechanisms for how proteins can sense these mechanical signals and convert them to biochemical signals, thereby uncovering new signaling pathways and potentially identifying new therapeutic targets.

PI_NAMEs: OAKES, PATRICK WILLIAM (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Ablation;Actins;adhesion receptor;Adhesions;Affect;Architecture;Binding;Binding Proteins;Binding Sites;Biochemical;biophysical techniques;Breathing;Cancerous;cell behavior;Cells;Cellular biology;Cellular Structures;Chimera organism;Cytoskeleton;Data;Development;Disease;Environment;experimental study;extracellular;Extracellular Matrix;Family;Family member;Focal Adhesions;Impairment;Individual;insight;Integrins;Kinetics;Knowledge;Lasers;LIM Domain;LIM Domain Protein;Location;Machine Learning;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Microfilaments;migration;Molecular Conformation;Motor;new therapeutic target;novel;optogenetics;paxillin;Phenylalanine;Phosphorylation;Physiological Processes;Physiology;Play;polymerization;Polymers;pressure;Process;protein purification;Proteins;PTK2 gene;recruit;repaired;Research;respiratory smooth muscle;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Smooth Muscle Myocytes;Stress;Stress Fibers;Stretching;Structure;Talin;Testing;Tissues;Traction;transmission process;Vinculin;Work;ZYX gene

PROJECT_TITLE: Mechanotransduction via LIM Domain Protein Mechanosensing

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE (Public Health Relevance) Based on recent findings from our collaborative laboratories, we propose a very innovative hypothesis for systemic sclerosis (SSc) pathogenesis implicating altered NAD metabolism. This proposal will determine the cellular, metabolic and epigenetic events associated with dysregulated NAD metabolism that underlie pathogenesis and progression in SSc, and can be selectively targeted for effective therapy.

PI_NAMEs: CHINI, EDUARDO N;VARGA, JOHN  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Ablation;Address;Animal Model;Automobile Driving;Biopsy;Bleomycin;Blocking Antibodies;Cell Reprogramming;cell type;Cells;chromatin remodeling;Chronic Disease;Complex;Computer Analysis;Confocal Microscopy;Consumption;Couples;Coupling;Development;Disease;disease model;effective therapy;Engineering;Enzymes;Epigenetic Process;Event;Fibroblasts;Fibrosis;Genetic;guided inquiry;Homeostasis;human subject;Immune;In Vitro;in vivo;indium-bleomycin;Infiltration;innovation;insight;Knockout Mice;Laboratories;Link;LoxP-flanked allele;Lung;Maps;Mediating;Metabolic;Metabolism;Methylation;methylome;Modeling;mouse model;Mus;Myofibroblast;NAD+ Nucleosidase;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide N-Methyltransferase;novel;novel strategies;novel therapeutic intervention;Organ;Organ Model;Pathogenesis;Pathogenicity;Pathologic;Patients;pharmacologic;Phenotype;Play;prevent;Process;public health relevance;Pulmonary Fibrosis;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Sampling;Scheme;Scleroderma;Severities;single-cell RNA sequencing;Skin;skin biopsy;skin fibrosis;Source;Stromal Cells;Systemic Scleroderma;targeted treatment;Tissues;Transferase;Transforming Growth Factor beta;Up-Regulation

PROJECT_TITLE: CD38 modulation of NAD metabolism driving scleroderma pathogenesis


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurosciences;Pain Research;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Common chronic overlapping pain syndromes (COPCs), such as fibromyalgia and temporomandibular disorder, constitute one of our nation’s most significant healthcare problems, affecting nearly one in every three Americans. Despite their high prevalence, COPCs remain ineffectively treated, in large part, due to lack of valid animal models with translational relevance for discovery of safe effective therapies. Thus, the objective of this proposal is to develop and validate a novel mouse model of COPCs in which genetically predisposed mice undergo stressful and injurious events resulting in clinically-relevant behavioral and molecular phenotypes for in vivo screening of analgesic therapeutics.

PI_NAMEs: NACKLEY, ANDREA G (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Abdomen;Affect;American;Analgesics;Animal Model;Antiinflammatory Effect;anxiety-like behavior;Automobile Driving;Back;Behavior;behavioral phenotyping;Bilateral;Biological Markers;calcium indicator;Catechol O-Methyltransferase;Catecholamines;celecoxib;Chronic;chronic pain;Clinical;clinical effect;clinically relevant;Complex;cytokine;Data;depressive symptoms;duloxetine;effective therapy;Environmental Risk Factor;Enzymes;Etiology;Event;Exhibits;FDA approved;Female;Fibromyalgia;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genotype;Healthcare;High Prevalence;Hyperalgesia;improved;in vivo;in vivo calcium imaging;Individual;Inflammation;Inflammatory;Injury;Lead;male;Mastectomy;Measures;mechanical allodynia;Mechanics;meetings;Modeling;molecular phenotype;mouse model;multiplex assay;Mus;Nerve;Nociceptors;novel;Operative Surgical Procedures;Pain;pain behavior;pain model;pain reduction;Parents;Patients;Peripheral;Peripheral Nerves;Persistent pain;Persons;pharmacologic;Phase;Plasma;pregabalin;Production;psychologic;Reporting;response;Rodent;Rodent Model;Sampling;screening;Site;Stimulus;Stress;Stressful Event;Swimming;Syndrome;Temporomandibular Joint Disorders;Testing;Therapeutic;Time;Variant;Vehicle crash;Vulva;Wild Type Mouse;Woman;Work

PROJECT_TITLE: A novel clinically- relevant mouse model of chronic overlapping pain conditions for screening analgesics

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ORG_CITY: CORAL GABLES

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Relevant statement Our proposal will identify an itch-specific brain circuit and dopamine genes influencing individual differences in itch perception. Success of our project has the potential to develop genetic information based tailored itch treatment targeting the brain. This will eventually help the many chronic itch patients regardless of the underlying etiology.

PI_NAMEs: MOCHIZUKI, HIDEKI  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Achievement;Affect;Alleles;Area;Binding;Brain;brain based;Brain imaging;Brain region;Brain Stem;chronic itch;Corpus striatum structure;Development;Disease;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dorsal;Esthesia;Etiology;Functional Magnetic Resonance Imaging;Genes;Genetic;genetic information;Genetic Polymorphism;Genotype;global health;Human;imaging study;Individual Differences;Investigation;Location;Methods;Motivation;Motor;Neurotransmitters;novel;Pain;pain sensation;Participant;Pathway interactions;Patients;Perception;Persons;Play;Prefrontal Cortex;Pruritus;Reporting;Research Project Grants;Research Proposals;Role;Signal Transduction;Spinal;Stimulus;success;Thalamic structure;therapeutic target;Work

PROJECT_TITLE: Itch-specific brain circuit and dopaminergic gene polymorphisms influencing individual differences in itch perception

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ORG_CITY: ALBUQUERQUE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative: The anti-tumor immunity induced by oncolytic virotherapy is blunted by numerous poorly characterized cellular pathways. For example, our preliminary data demonstrates the presence of TNF within the tumor microenvironment prevents effective oncolytic therapy by directly killing anti-tumor T cells. The current proposal will more fully examine the impact of TNF on oncolytic therapy by understanding the molecular mechanisms involved and identifying how to best translate these findings into human patients.

PI_NAMEs: BARTEE, ERIC CARTER (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Address;anti-tumor immune response;Antibodies;Apoptosis;Binding;cancer infiltrating T cells;Cells;Chimeric Proteins;Clinical;clinical application;clinical effect;clinical translation;Data;design;Development;Disease;Enzymes;Failure;FDA approved;Follow-Up Studies;Genetic;Goals;Human;Immune;immune clearance;immune-related adverse events;improved;in vivo;Inflammation;inhibitor;Interferons;Interleukin-12;Knowledge;Mediating;Membrane;Methods;Modeling;Molecular;Myxoma virus;Nature;novel;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Outcome;Pathway interactions;Patients;PD-1 inhibitors;PD-1/PD-L1;Play;Pre-Clinical Model;prevent;Property;Receptors, Tumor Necrosis Factor, Type II;Regulatory Pathway;Role;Solid Neoplasm;Specificity;success;synergism;T-Lymphocyte;Testing;Therapeutic antibodies;TNF gene;TNFRSF1B gene;Toxic effect;Translating;Translations;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Viral;Virus;Virus Replication;Work

PROJECT_TITLE: Impact of TNF on Oncolytic Virotherapy

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ORG_CITY: STANFORD

ORG_DEPT: ORTHOPEDICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed research aims to provide new insights in Osteoarthritis (OA), an unmet medical need from a fresh perspective of how cellular response to changes in the mechanical properties of its surrounding matrix drive the initiation and progression of OA. Completion of these studies will lead to an increased molecular understanding of such responses, which should help in accelerating drug development efforts as well as development of tissue-engineered products for OA.

PI_NAMEs: BHUTANI, NIDHI  (contact);CHAUDHURI, OVIJIT

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Adult;Affect;Age Years;Alginates;articular cartilage;Biochemical;Bioinformatics;Biology;Biomedical Engineering;biophysical properties;Biophysics;Bypass;Calcium;Calcium Channel;Calcium Signaling;Cartilage;cartilage cell;cartilage development;Cartilage injury;cartilage regeneration;cartilage repair;Cell Volumes;Cells;Chondrocytes;Clinical;Clinical Engineering;clinically relevant;Complex;Cues;cytokine;Data;Defect;Degenerative polyarthritis;Development;differential expression;Disease;drug development;efficacy testing;Elasticity;Engineering;Exhibits;Exposure to;Extracellular Matrix;FDA approved;Femur;Gel;Gene Expression;Generations;Genetic;Health;Histologic;Homeostasis;Human;human induced pluripotent stem cells;Hydrogels;Immunodeficient Mouse;Impairment;in vitro testing;in vivo;in vivo evaluation;Inflammation;Inflammatory;insight;International;Ion Channel;Joints;knock-down;Laboratories;Lead;mechanical load;mechanical properties;mechanotransduction;Medical;Methods;Modeling;Molecular;Movement;Nature;new therapeutic target;Nude Rats;Operative Surgical Procedures;Outcome Study;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Preparation;Production;Publishing;Quality of life;Rattus;receptor;Regulation;Relaxation;repaired;Research;response;Role;scaffold;Signal Pathway;Societies;Stress;Stretching;subcutaneous;System;Testing;Therapeutic;Tissue Engineering;tissue repair;Tissues;transcription factor;transcriptome sequencing;Transplantation;viscoelasticity;Viscosity;voltage

PROJECT_TITLE: Regulation of chondrocyte fate and function by ECM Viscoelasticity

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Abnormal modifications have been long hypothesized as a factor that contributes to the forms of tau proteins observed in Alzheimer’s disease. However, this has not been conclusively tested, and whether the various tau species contribute to toxicity remains unknown. We aim to answer this question by enabling exact modifications in tau and testing their effect on physiologically relevant properties.

PI_NAMEs: CHO, YONGKU PETER (contact);RINEHART, JESSE

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acetylation;Adopted;Affect;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Antibodies;Antibody Specificity;Binding;Biological Assay;Biosensor;Brain;Cell Line;Collection;combinatorial;crosslink;Cryoelectron Microscopy;Data;Disease;Gel;Generations;Genes;Goals;Human;Individual;Length;Libraries;Lysine;Mass Spectrum Analysis;Measures;Mediating;Methods;Microtubules;Modification;Molecular;Molecular Conformation;Molecular Profiling;Monoclonal Antibodies;monomer;mutant;Neurodegenerative Disorders;neurotoxicity;novel;Pathogenicity;Pathologic;Patients;Phosphorylation;Phosphoserine;Phosphothreonine;Physiological;Polymorph;Post-Translational Protein Processing;Preparation;Production;Property;Protein Engineering;Rapid screening;Reagent;Recombinants;Resolution;Resources;Site;Source;synthetic biology;System;tandem mass spectrometry;tau aggregation;tau conformation;tau Proteins;tau-1;Tauopathies;Testing;Time;Toxic effect

PROJECT_TITLE: A synthetic biology approach for tau post-translational modifications in AD

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Organ Transplantation;Rare Diseases;Transplantation

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Epstein Barr virus (EBV) infection is associated with significant morbidity and mortality in solid organ transplant recipients including the development of EBV+ B cell lymphomas and post-transplant lymphoproliferative disease (PTLD). The goal of our study is to determine how EBV genetic diversity, leading to alterations in viral gene function and immune recognition, contributes to the pathogenesis of EBV+ PTLD.

PI_NAMEs: KRAMS, SHERI M.;MARTINEZ, OLIVIA M (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Activities of Daily Living;adaptive immune response;Allografting;antiviral immunity;B-Cell Lymphomas;B-Lymphocytes;biobank;Blood;Cell Physiology;Cell Proliferation;Cell Survival;cell transformation;Cells;Characteristics;Custom;Cytometry;Development;Epithelium;Epstein Barr Virus B cell lymphoma;Epstein Barr Virus B lymphoma cell;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;extracellular vesicles;FOS gene;gain of function mutation;gammaherpesvirus;gene function;Genes;Genetic Variation;genome sequencing;Goals;high dimensionality;HIV;Human Herpesvirus 4;Immune;Immune response;Immunity;Immunocompromised Host;immunoregulation;immunosuppressed;Immunosuppression;Impairment;Individual;infected B cell;Infection;innovation;Life;Link;Lymphoid;Lymphomagenesis;Lymphoproliferative Disorders;Lytic Phase;Lytic Virus;Malignant Neoplasms;MAP Kinase Gene;Membrane Proteins;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Mutation;Natural Killer Cells;NCAM1 gene;novel;Oncogenes;organ transplant recipient;Organ Transplantation;Pathogenesis;Patients;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Population;post-transplant;Predisposing Factor;prevent;Proliferating;prospective;Proteins;response;Risk;Role;Sampling;Signal Pathway;Solid;T cell response;T-Lymphocyte;Testing;Therapeutic;Transcription Factor AP-1;transforming virus;Transplant Recipients;tumor;Variant;Viral;Viral Genes;Viral Pathogenesis;Viral Proteins;Virus;virus genetics;whole genome;Work

PROJECT_TITLE: Epstein Barr Virus Driven Mechanisms of Post Transplant Lymphoproliferative Disease


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infant Mortality;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Early rupture of the “bag of waters”, known as the fetal membranes, often results in preterm birth with increased risk of infant mortality and morbidity. This research investigates how the hormone progesterone prevents the fetal membranes from rupturing and how its production is controlled. Understanding how this natural protection works may lead to therapies to prevent early rupture and preterm birth.

PI_NAMEs: MESIANO, SAM ANTONIO;MOORE, JOHN J (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 37 weeks gestation;Address;Affect;amnion;Anti-Inflammatory Agents;Back;Birth;Cell Culture Techniques;Cells;Chorion;clinically significant;cytokine;cytotrophoblast;Data;Decidua;decidua parietalis;Development;effective therapy;Enzymes;Event;Feedback;Feeds;Fetal Membranes;Genetic;Granulocyte-Macrophage Colony-Stimulating Factor;Hemorrhage;Hormones;Human;Induced Labor;infant morbidity/mortality;Infant Mortality;Infection;Inflammation;Inflammation Mediators;Inflammatory;innovation;Knowledge;Labor Onset;Link;Maternal-Fetal Exchange;Mechanics;Mediating;Metabolism;Methods;Modeling;Molecular;myometrium;neonatal morbidity;Neonatal Mortality;new therapeutic target;novel;Nuclear;paracrine;Pathway interactions;Pregnancy;Pregnancy Maintenance;premature;Premature Birth;prevent;Process;Production;Progesterone;receptor;Regulation;Research;Research Personnel;response;Risk;RU-5020;Rupture;Signal Pathway;Signal Transduction;steroid hormone;Stimulus;Stromal Cells;System;Testing;Therapeutic;therapy development;Tissues;trophoblast;Water;Withdrawal;Work

PROJECT_TITLE: Paracrine control of the maternal-fetal interface critical for pregnancy wellness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-C(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Early identification of cognitive impairment and dementia is associated with multiple public health benefits and will become even more important if a disease-modifying treatments for Alzheimer’s disease becomes widely available. However, delayed or missed identification of dementia is common, particularly among people from racial and ethnic minority backgrounds and disadvantaged socioeconomic status. In this mixed-methods study we will identify barriers to early identification of dementia in older adults who receive healthcare in a safety net health system.

PI_NAMEs: JOE, ELIZABETH BARTELT (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adoption;Adult;Affect;Aging;aging process;Alzheimer's Disease;Awareness;barrier to care;Behavioral;Belief;beneficiary;Black race;care delivery;care seeking;Caregivers;Caring;Clinical;cognitive testing;Complement;cost;Country;County;Data;Data Set;Dementia;dementia care;Demographic Factors;Diagnosis;Diagnostic;Diagnostic tests;Disadvantaged;disadvantaged background;Disease;Disparity in diagnosis;Early identification;economic need;Elderly;Electronic Health Record;Eligibility Determination;Equity;ethnic minority;Evaluation;evidence base;experience;Family;Family member;Fright;Future;Goals;Health Benefit;health care availability;health disparity;health literacy;Health Services;Health Services Accessibility;Health Services Research;Health Status;Health system;Healthcare;Healthcare Systems;Hispanic;Impaired cognition;improved;Intervention;Interview;Knowledge;Logistic Regressions;Los Angeles;Measures;Medical;Medicare;Memory;Memory Disorders;Memory impairment;Memory Loss;Methods;Minority;modifiable risk;Municipalities;Needs Assessment;Neurobehavioral Manifestations;Not Hispanic or Latino;older adult;Pathway interactions;patient population;Patient Self-Report;patient subsets;Patients;Persons;Physicians;Population;Preventive care;Primary Care;Provider;psychologic;psychosocial;Public Health;racial minority;racial minority population;Reduce health disparities;Resources;response;Risk Factors;safety net;screening;shared decision making;social stigma;socioeconomic disadvantage;Socioeconomic Status;Spanish/English;Structure;Surveys;Symptoms;Trust;Visit;wellness visit;willingness

PROJECT_TITLE: Barriers to early identification of dementia in a safety net healthcare system


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Wound Healing and Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH Chronic wound infections are a growing public health threat and can result in significant quality of life reduction, hospitalization, amputation and death. We propose to optimize acoustically responsive particles and therapeutic ultrasound to improve antibiotic efficacy against infected wounds. We will examine the ability of our therapeutic platform to predict therapeutic response in terms of both infection control and wound healing, with the long-term goal of personalizing wound care.

PI_NAMEs: PAPADOPOULOU, VIRGINIE  (contact);ROWE, SARAH ELIZABETH

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acoustics;Adjuvant;Affect;Amputation;Animals;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteria;bacterial community;Bacterial Infections;Benchmarking;Biological;biomaterial compatibility;Blood Vessels;Cardiovascular Diseases;Cells;Cessation of life;Chemosensitization;chronic wound;Clinical;clinical translation;Clinical Trials;comorbidity;Contrast Media;cost;Data;Detection;detection limit;Development;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic mouse;Diameter;Drug Delivery Systems;Drug Tolerance;efficacy evaluation;Enterococcus faecalis;experience;Failure;Goals;Hospitalization;Immune;Impaired healing;Impaired wound healing;improved;In Vitro;in vitro activity;in vivo;Infection;Infection Control;innovation;Lead;Letters;Measures;Mediating;Metabolic;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microbubbles;Modeling;Moon;mouse model;multidisciplinary;nanosized;novel therapeutic intervention;Nutrient;Organism;Oxygen;particle;pathogen;Patients;Penetration;Persons;Pharmaceutical Preparations;phase change;Physicians;polymicrobial biofilm;Prediction of Response to Therapy;Pseudomonas aeruginosa;Public Health;Quality of life;recurrent infection;Research;Resistance;Sepsis;Sonication;standard of care;Staphylococcus aureus;Study models;Technology;theranostics;Therapeutic;Topical application;treatment response;ultrasound;Work;wound care;wound closure;wound healing;Wound Infection;Wound models;wound treatment

PROJECT_TITLE: A theranostic ultrasound approach to improve chronic wound treatment using phase-change contrast agents

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Life-threatening fungal infections are an escalating human health problem because of limited treatment options and the evolution of drug resistant pathogens. Thus, identification and validation of new targets for therapeutics is an urgent need. This project will introduce a powerful functional genomics technology for human fungal pathogens that will accelerate the identification and characterization of promising drug targets and factors involved in virulence and drug resistance.

PI_NAMEs: HALL, MARK C (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acceleration;analog;Animal Model;Animals;anti-fungal agents;Antibiotics;Aspergillus;Auxins;Benign;Biology;C-terminal;Candida;Candida albicans;Candida auris;Candida glabrata;Candidiasis;Chemicals;chimera drug;climate change;Clinical;Communities;conditional mutant;CRISPR/Cas technology;Dependence;detection platform;Development;Disease Outbreaks;Disseminated candidiasis;DNA cassette;Dose;drug development;drug discovery;Drug resistance;drug resistant pathogen;Drug Targeting;Effectiveness;emerging pathogen;Engineering;Evaluation;Evolution;experimental study;Fluorescence;Frequencies;functional genomics;Fungal Drug Resistance;Fungi Model;Future;Gene Deletion;gene product;gene repression;Genes;genomic tools;global health;Health;histone acetyltransferase;Hospitals;Human;Immune;immunosuppressed;in vivo;Individual;Infection;inhibitor;interest;Kinetics;Larva;Life;Malignant Neoplasms;Methods;Modeling;Molecular Biology;Molecular Target;mouse model;Multi-Drug Resistance;Mus;Mycoses;N-terminal;new therapeutic target;novel;pathogen;Pathogenesis;pathogenic fungus;Performance;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Physiological;Predisposition;priority pathogen;promoter;Protac;protein function;Proteins;Protocols documentation;Reagent;Reporter;Reporting;Research;resistance factors;resistance in Candida auris;Saccharomyces cerevisiae;secondary infection;severe COVID-19;Severities;simulation;System;Technology;technology platform;Testing;Therapeutic;therapeutic development;Time;tool;Validation;Virulence;Work;World Health;World Health Organization

PROJECT_TITLE: Development and application of auxin-inducible degradation in Candida pathogens

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Rates of syphilis infection have risen steeply, disproportionately impacting populations of color and sexual and gender minority persons, particularly men and transgender women who have sex with men. A new method for preventing syphilis, consisting of doxycycline post-exposure prophylaxis, is showing promise in research studies. This study seeks to understand how to support adoption of doxycycline post-exposure prophylaxis in populations most impacted by syphilis in the United States.

PI_NAMEs: MCNULTY, MOIRA  (contact);PYRA, MARIA

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Adoption;Affect;Antibiotics;Attitude;Behavior;behavior change;Black Populations;Black race;burden of illness;Characteristics;Chicago;Clinic;Communities;community advisory board;Community Health;Consolidated Framework for Implementation Research;Contact Tracing;Data;Development;Doxycycline;Early identification;Education;effectiveness evaluation;Eligibility Determination;Ensure;Epidemic;Equity;Evidence based intervention;experience;Face;Future;gender minority group;Health;health equity;Health Priorities;Health Services;Health system;Hispanic;HIV;Illinois;implementation barriers;implementation framework;implementation research;implementation science;implementation strategy;Individual;Inequity;Infection;innovation;interest;Interview;Knowledge;Latinx;Latinx population;Locales;men;men who have sex with men;Methods;Modeling;Morbidity - disease rate;Motivation;novel;oral HIV;patient population;Patient Preferences;Patients;people of color;Population;pre-exposure prophylaxis;pressure;prevent;Prevention;Prevention strategy;Prophylactic treatment;Provider;provider-level barriers;Public Health;Qualitative Methods;Research;research study;response;Self Efficacy;service delivery;sex;Sex Behavior;Sexual and Gender Minorities;Sexual Health;social;stem;Structure;Surveys;syndemic;Syphilis;Testing;tool;transgender women;transgender women who have sex with men;transmission process;United States;uptake;Work

PROJECT_TITLE: Identifying Community-Informed DoxyPEP Implementation Strategies to Guide Equitable Delivery of Syphilis Prevention

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative The role of metabolism in the heart and in cardiovascular (patho)pathology is poorly understood. This project will determine how the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase 2, influences fibroblast biology and affects cardiac remodeling after myocardial infarction.

PI_NAMEs: WELLS, COLLIN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Amino Acids;Anabolism;Biology;Blood Vessels;Carbon;Cardiac;Cardiovascular system;Cell division;Chronic;Citric Acid Cycle;Collagen;coronary fibrosis;Data;Deposition;Development;diminished oxidative phosphorylation;Enzymes;extracellular;Extracellular Matrix;Fibroblasts;Fibrosis;Genetic Transcription;Gluconeogenesis;Glucose;glucose metabolism;Glutaminase;Glutamine;Glycolysis;Heart;Heart Injuries;in vivo;Infarction;Knowledge;Ligands;meetings;Metabolic;Metabolic Pathway;Metabolism;mouse model;Myocardial Infarction;Myofibroblast;Nucleotides;Output;Pathology;Pathway interactions;Phase;Phenotype;Phosphoenolpyruvate Carboxylase;Phospholipids;Positioning Attribute;Process;Production;programs;Proliferating;Protein Secretion;response;Role;Serine;Source;Stimulus;Testing;therapeutic target;Transcript;transcriptome sequencing;transdifferentiation;Transforming Growth Factor beta;virtual

PROJECT_TITLE: Role of Pck2 in cardiac fibrosis


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Advances in Magnetic Resonance Imaging (MRI) now support regional imaging of lung structures with CT-like contrast and high spatial resolution. The versatility of MRI data acquisition includes motion detection that can be used to track changes in lung inflation and oxygen distribution during free-breathing. This project will develop oxygen-enhanced imaging of ventilation of the lungs and high-resolution acquisition of lung anatomy in a single, free-breathing 7-minute acquisition using 3D ultra-short time to echo MRI and study multiple chronic lung diseases to establish utility and reproducibility.

PI_NAMEs: FAIN, SEAN BEDILION (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 3-Dimensional;Agreement;airway obstruction;Anatomy;Asthma;Blood;Breathing;Bronchiectasis;Bronchiolitis;Chest;chest computed tomography;Chest imaging;Chronic;Chronic lung disease;Clinical;Clinical Management;Communicable Diseases;Compensation;Complement;Cystic Fibrosis;Data;data acquisition;deep learning;deep learning model;design;Detection;Devices;Disease;Early Diagnosis;Elements;Environmental Risk Factor;Equilibrium;experience;Exposure to;Fibrosis;Frequencies;Functional disorder;Gases;Genetic Diseases;Glass;Goals;Granuloma;Healthcare;Heterogeneity;Image;Image Enhancement;imaging modality;improved;Incidence;Information Dissemination;Intervention;Ionizing radiation;Krypton;Learning;Localized Disease;Lung;Lung Diseases;lung imaging;lung lobe;Lung Transplantation;lung volume;Magnetic Resonance Imaging;Maps;Measurement;Methodology;Methods;Modeling;Monitor;Morphologic artifacts;Motion;Mucous body substance;Nodule;Noise;Nuclear;Outcome;Oxygen;Pathology;Patients;Pattern;Perfusion;Population;Prevalence;Process;Protocols documentation;Protons;Pulmonary Fibrosis;Pulmonary function tests;pulmonary symptom;Radiation exposure;radiologist;Radiology Specialty;Reader;reconstruction;Reproducibility;Resolution;respiratory;Respiratory Disease;Scanning;Series;single photon emission computed tomography;Site;Spirometry;structural imaging;Structure;Structure of parenchyma of lung;success;System;Techniques;Testing;therapy development;Thoracic Radiography;Time;tool;Treatment Efficacy;United States;ventilation;Visualization;Visualization software;Work;X-Ray Computed Tomography;Xenon

PROJECT_TITLE: Dynamic Imaging of Lung Ventilation and Perfusion Using CT and MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Cancer;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative  Two of the most prominent cancers of the GI tract in the U.S. are colorectal cancer (CRC) and esophageal adenocarcinoma(EAC): CRC is the second leading cause of cancer deaths, and EAC has been the fastest increasing cause of cancer deaths over the past four decades. There is clearly unmet need for effective cancer prevention and early detection for CRC and EAC. This award will provide support for an exceptional translational cancer research scientist, Dr. Yu, to perform studies that will advance our understanding of molecular alterations in the initiation and progression of GI cancers, and accelerate the development of biomarkers for cancer prevention and early detection.

PI_NAMEs: YU, MING  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Aberrant DNA Methylation;Acceleration;adenoma;Atlases;Automobile Driving;Award;Barrett Esophagus;Basic Science;Biological Markers;Biological Models;biomarker development;Cancer Etiology;cancer initiation;cancer prevention;carcinogenesis;Carcinoma;Cells;Cessation of life;Clinical;Clonal Expansion;Colon;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;DNA Methylation;Early Detection Research Network;Early Diagnosis;Ensure;Epigenetic Process;Epithelial Cells;Esophageal Adenocarcinoma;Fibroblasts;Funding;Gastrointestinal tract structure;Gene Mutation;High grade dysplasia;improved;in vivo Model;insight;Lesion;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;methylation pattern;Molecular;Molecular Carcinogenesis;novel;Patients;Polyps;premalignant;Prevention;Prevention therapy;Process;Prognosis;programs;progression marker;Public Health;Reproducibility;Research;Risk;Risk Marker;Role;Sampling;Scientist;senescence;Specialist;tissue biomarkers;Tissues;translational cancer research;Translational Research;Translations;tumor;tumor progression;Tumor Promotion;tumorigenic

PROJECT_TITLE: Translational Science of Gastrointestinal Cancer Initiation and Progression


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: This project aims to develop a lead candidate therapeutic, AAV9/AGA, as a treatment for a devastating and currently untreatable neurodegenerative disorder, Aspartylglucosaminuria (AGU). Aims are proposed to assess the safety of AAV9/AGA in preclinical models, manufacture AAV9/AGA for human use, further explore and refine clinical biomarkers relevant to assess an AGU treatment, and obtain regulatory approvals to initiate a Phase I/II clinical trial of AAV9/AGA in AGU patients. These efforts will not only lead a potentially transformative treatment for AGU, but also inform the development of similar treatments for a wide range of inherited neurological disorders.

PI_NAMEs: GRAY, STEVEN J (contact);MINASSIAN, BERGE A

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: adeno-associated virus 9 delivery;Aspartylglucosaminuria;associated symptom;Behavioral;Biochemical;Biological Assay;Biological Markers;Blood;Body Fluids;Brain region;Caregivers;Child;Childhood;Clinical;clinical biomarkers;clinical center;Clinical Trials;Clinical Trials Data Monitoring Committees;Code;Cognitive;Communication;Data;Deformity;design;Deterioration;Development;Disease;Dose;enzyme activity;enzyme substrate;Enzymes;Feasibility Studies;first-in-human;Foundations;Functional disorder;Funding;gene therapy;gene therapy clinical trial;Gene therapy trial;Genes;Genetic;giant axonal neuropathy;Glycoproteins;good laboratory practice;Histopathology;Human;Hypertrophy;Image;imaging biomarker;Immune response;Impairment;in vivo;Individual;Inherited;institutional biosafety committee;Institutional Review Boards;Intellectual functioning disability;Investigational Drugs;Investigational New Drug Application;Joints;large scale production;Lead;lead candidate;Life;life span;Lysosomes;Magnetic Resonance Spectroscopy;manufacture;Measurement;Measures;Medical center;meetings;Methodology;Motor;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Nonprofit Organizations;novel therapeutics;Online Mendelian Inheritance In Man;Outcome;Parents;Patients;Pharmaceutical Preparations;Phase;phase I trial;Phase I/II Clinical Trial;pre-clinical;Pre-Clinical Model;preclinical study;Psyche structure;Psychomotor Performance;Publishing;Rattus;Research Personnel;Resources;safety assessment;safety testing;Sampling;skeletal;Spastic Paraplegia;specific biomarkers;Spielmeyer-Vogt Disease;Supportive care;Symptoms;Technology;Technology Transfer;therapeutic candidate;Tissues;Toxicology;trait;Translations;United States National Institutes of Health;Urine;vector

PROJECT_TITLE: IND-enabling studies for Aspartylglucosaminuria (AGU) to support the initiation of an AAV9/AGA gene transfer clinical trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Normal cognitive function requires an adequate blood supply to support neuronal activity via neurovascular coupling, and recent evidence demonstrates that age-related cognitive decline that manifests in Alzheimer’s dis- ease and related dementias (ADRD) is directly linked to reduced neurovascular coupling (NVC) responses. Caloric restriction exerts multifaceted anti-aging and lifespan-extending effects and has been demonstrated to be an effec- tive nutritional intervention that can improve vascular health and cognitive function, however, adherence to caloric restriction remains a challenge and a translational barrier as most humans may not be able, or willing, to reduce their caloric intake by 30% over extended periods of time. Based on the abundant literature in the field, our pub- lished preclinical results and preliminary data in humans, these series of studies are designed to assess a clinically relevant lifestyle intervention of time restricted eating to improve endothelial function and NVC responses in com- munity dwelling older adults to prevent and, potentially to treat, age-related cognitive decline associated with ADRD.

PI_NAMEs: TARANTINI, STEFANO ;YABLUCHANSKIY, ANDRIY  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adherence;Affect;Age;age related;Age Years;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;anti aging;Attenuated;Biological Availability;Blood;Blood Vessels;Brain;brain endothelial cell;Brain region;Caloric Restriction;Calories;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;Cerebrum;circulating biomarkers;Clinical;Clinical Research;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;Communities;Consumption;Data;Deacetylation;Dementia;design;Development;Diet Habits;Dietary Intervention;Eating;Elderly;Endothelial Cells;Endothelium;Energy Intake;extend lifespan;Fasting;Functional disorder;functional near infrared spectroscopy;Goals;Health;high risk;Hour;Human;human subject;Hyperemia;Impaired cognition;Impairment;improved;improved outcome;Individual;Inflammation;innovative technologies;Intake;Intermittent fasting;Laser Speckle Imaging;lifestyle factors;lifestyle intervention;Link;Literature;Mediating;Neurons;neurovascular;neurovascular coupling;novel therapeutic intervention;Nutrient;nutrition;old mice;older adult;Oxidative Stress;Oxygen;Participant;Pathogenesis;Pathway interactions;Performance;Peripheral;Play;pre-clinical;preservation;prevent;Prevention;Prevention approach;Public Health;Publishing;Research;response;retina blood vessel structure;Role;Series;Serum;SIRT1 gene;Stimulus;Testing;Therapeutic Intervention;Time;Time-restricted feeding;translational barrier;Vascular blood supply;Vascular Cognitive Impairment;Vascular Endothelium;Vasodilation

PROJECT_TITLE: Time restricted eating for prevention of age-related vascular cognitive decline in older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Lung

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Hepatopulmonary syndrome (HPS), the most common lung complication in cirrhosis, results in impaired transfer of oxygen into the blood, increases the risk of dying and has no effective medical treatments. The current proposal focuses on the novel hypothesis that bile acids, increased in cirrhosis, impair the function of the lung surfactant system and contribute to decreased oxygen and poor outcomes. Our goal is to develop effective treatments for HPS.

PI_NAMEs: DAI, ZHIYU ;FALLON, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Affect;Alveolar;alveolar epithelium;Alveolus;American;angiogenesis;Animal Model;Apoptosis;Arteriovenous malformation;Bile Acids;Blood;Blood Vessels;Cell Physiology;Cell Proliferation;Cells;chronic liver disease;Cirrhosis;cohort;Common bile duct structure;comparative;Compensation;Complication;Data;Defect;Development;early phase trial;effective therapy;Foundations;Functional disorder;Gases;Gene Modified;Genetic;Goals;Hepatopulmonary Syndrome;Human;human disease;human model;Hypoxemia;Impairment;In Vitro;in vivo;innovation;interest;Knowledge;Ligation;Liver diseases;liver transplantation;Lung;lung injury;Mediating;Medical;Microcirculation;Modeling;Molecular;mortality;Mus;new therapeutic target;novel;novel therapeutic intervention;Outcome;Oxygen;Patients;Physiological;Population;pre-clinical;Pulmonary Fibrosis;pulmonary function;Pulmonary Surfactants;Quality of life;receptor;Reporter;Risk;Rodent;Role;Serum;Severities;Signal Transduction;single-cell RNA sequencing;Study models;Supplementation;Surface Tension;surfactant;surfactant function;surfactant production;System;Testing;United States National Institutes of Health;Vascular remodeling;Work

PROJECT_TITLE: Novel alveolar mechanisms of hypoxemia in hepatopulmonary syndrome

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NAPERVILLE

ORG_NAME: HUMAN CELL CO

PHR: NARRATIVE  The efficacy and safety of an optimized human nerve growth factor will be evaluated in clinically relevant animal models of glaucoma.

PI_NAMEs: JEONG, SOON SEOG  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Age;Animal Model;Apoptosis;Astrocytosis;Attenuated;Axon;Axonal Transport;Benefits and Risks;Bilateral;Binding;blind;Blindness;Cauterize;Cell Physiology;Cell Proliferation;Cell Survival;Characteristics;Chronic;Clinical Trials;clinically relevant;conjunctiva;Contrast Sensitivity;Corneal Ulcer;cost;cost effective;Cyclic GMP;Cytoprotection;Data;design;diabetic;diabetic ulcer;Disease;disease model;Dose;drug development;Drug usage;Dry Eye Syndromes;efficacy validation;Electrophysiology (science);Engineering;Escherichia coli;experience;Eye;eye dryness;Eyedrops;FDA approved;Glaucoma;Goals;Half-Life;Human;Hypotensives;improved;Individual;innovation;Licensing;Life;Mammalian Cell;manufacture;Mediating;Microspheres;Modeling;modifiable risk;Modification;Mus;Nerve Growth Factors;neuroprotection;Neurotrophic Keratitis;Neurotrophic Tyrosine Kinase Receptor Type 1;NGFR Protein;nonhuman primate;novel therapeutics;Open-Angle Glaucoma;Optic Nerve;Oryctolagus cuniculus;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;phase 1 study;Phase Ib Clinical Trial;Physiologic Intraocular Pressure;Placebo Control;Population;Pre-Clinical Model;preservation;prevent;Process;protein expression;Proteins;Rattus;Receptor Protein-Tyrosine Kinases;Recombinants;research clinical testing;response;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Running;Safety;safety study;Saimiri;Sclera;Scotoma;Serum;side effect;sight restoration;Signal Transduction;Site;Small Business Innovation Research Grant;success;System;Time;Topical application;Toxic effect;translation to humans;Treatment Factor;Tumor Necrosis Factor Receptor;Veins;Visual Acuity;Work

PROJECT_TITLE: Optimizing NGF for Topical Treatment of Glaucoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Contraception/Reproduction

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Public Health Relevance/Narrative Reproduction in flowering plants produces seeds thus provides for global nutritional needs, food security, and ensures ecological balance that is important for climate health. Yet the process involves complex male-female interplays and is highly sensitive to the environment, such as high and low temperatures, drought and flood, and reproductive failure devastates seed yields. Understanding the molecular mechanisms that lead to plant reproductive success will help designs of counter measures to reproductive loss and therefore relevant to NIH commitment to fundamental research in model organisms whose success ultimately protects human health.

PI_NAMEs: CHEUNG, ALICE Y. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Agriculture;Alkalinization;Angiosperms;Binding;Biochemical;Biochemical Process;Biological Process;Brassica;Capsid Proteins;Cell Communication;Cell fusion;Cell Nucleus;Cell Physiology;Cell Wall;Cells;climate-related health;cold temperature;Communication;Complex;Cytoplasm;Deposition;design;Disease;Dissection;Droughts;egg;Ensure;Environment;Equilibrium;Event;experimental study;Failure;Female;Fertilization;Floods;Flowers;Food Chain;food security;fundamental research;Future;Germination;Glycols;Goals;GPI Membrane Anchors;Growth;Health;High temperature of physical object;Homologous Gene;Human;improved;interest;Knowledge;Ligands;Location;male;Measures;Mediating;model organism;Modeling;Molecular;Motility;Mouse-ear Cress;Nitric Oxide;Nurses;Nutritional;Partner in relationship;Pectins;Penetration;Peptide Receptor;Peptides;Personal Satisfaction;Phase;Phosphotransferases;Pistil;Planets;Plants;Pollen;Pollen Tube;Positioning Attribute;prevent;Process;Production;Proliferating;Proteins;public health relevance;Qualifying;rational design;Reactive Oxygen Species;receptor;Reproduction;reproductive;reproductive success;Research;rho GTP-Binding Proteins;Signal Pathway;Signal Transduction;social stigma;sperm cell;success;Surface;Tissues;Transcription Factor AP-1;Translating;transmission process;United States National Institutes of Health;ward;Work;zygote

PROJECT_TITLE: Deciphering Male- and Female-coordinated Gating Mechanisms that Ensure Plant Reproductive Success

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]