ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: KS

PHR: Project Narrative By participating in this cooperative agreement, the Kansas Department of Agriculture (KDA) Feed Safety Program will aim to successfully maintain and continue to improve the Animal Feed Regulatory Standards (AFRPS) set forth by the FDA. In addition, the KDA Feed Safety Program will further develop the state’s Preventive Control (PC) regulatory work by enhancing its ability perform Current Good Manufacturing Practice (CGMP) & PC inspections under 21 CFR Part 507. The KDA Feed Safety Program aims to ensure a safer feed supply without adversely impacting the manufacturers of animal feed within the state of Kanas.

PI_NAMEs: JONES, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, SOMA

PROJECT_TITLE: Kansas Maintenance of the Animal Feed Regulatory Program Standards with Optional Coordinated Preventative Control


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PI_NAMEs: SANDERSON, MAUREEN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;base;behavioral health;Behavioral Sciences;Biometry;Breast;Breast Cancer Risk Factor;cancer care;Cancer Center;Cancer Control;cancer diagnosis;cancer health disparity;cancer subtypes;cancer therapy;care delivery;Categories;Clinical;clinical infrastructure;Clinical Research;clinical training;Clinical Trials;cohort;Collaborations;Collection;community advisory board;Community Developments;community engaged research;community engagement;comorbidity;Conduct Clinical Trials;Continuity of Patient Care;control trial;Coupled;Data;Death Rate;design;Disease;Disparity;doctoral student;Early Diagnosis;education research;Educational Materials;Eligibility Determination;Enrollment;Epidemiology;Equity;ethnic minority;Etiology;Evaluation;Exclusion;Exclusion Criteria;Experimental Designs;Future;General Hospitals;Goals;Health;Healthcare;improved;Incidence;inclusion criteria;Information Dissemination;Infrastructure;Institution;Intervention;Intervention Trial;Investigator-Initiated Research;Learning;Link;Logic;Longitudinal cohort;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mentorship;Methods;metropolitan;Minority Access;Mission;Modeling;neoplasm registry;Observational Study;Oncology;Outcome;outreach;Palliative Care;Participant;Pathology;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;population based;Population Research;Population Sciences;pre-doctoral;Prevention;prospective;Public Hospitals;racial minority;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Risk;Risk Assessment;Risk Factors;safety net;Science;Screening for cancer;Self Management;success;Supportive care;survivorship;Tennessee;Therapeutic Clinical Trial;Time;tobacco control;Training;trial design;Trust;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Practice Core


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC

PHR: PROJECT NARRATIVE A deeper understanding of the molecular and immunological mechanisms is urgently needed to improve the poor overall survival for high-risk neuroblastoma. Key insights may be learned by studying stromal cell-mediated extracellular matrix remodeling and the immune-stromal-ECM axis in the tumor microenvironment. The studies proposed will assess how cancer-associated fibroblast (CAF) heterogeneity affects ECM remodeling over neuroblastoma progression, examine tumor-CAF and CAF-immune signaling, and determine how perturbing ECM deposition and degradation affects tumor formation and progression. Together, these studies will generate new and exciting information about the tumor microenvironment and potential vulnerabilities to exploit in pediatric solid tumors.

PI_NAMEs: PETERSON, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Actins;ADAMTS;ADAMTS1 gene;Adrenal Glands;Adrenal Neuroblastoma;Adult;Affect;angiogenesis;anti-tumor immune response;Attention;Automobile Driving;Cancer Biology;cancer cell;CD4 Positive T Lymphocytes;cell type;Cells;Cephalic;Cessation of life;Chemicals;chemokine;Child;Childhood;Childhood Solid Neoplasm;Chromium;Chromosome Mapping;Collagen;Confocal Microscopy;crosslink;cytokine;Cytokine Gene;Data;Deposition;Development;Disease;Dissociation;Enterobacteria phage P1 Cre recombinase;Enzymes;Etiology;Evolution;experimental study;Extracellular Matrix;Fibroblasts;Flow Cytometry;Gene Deletion;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Heterogeneity;high risk;Immune;immune cell infiltrate;Immune signaling;Immune system;Immunocompetent;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunologics;improved;in vivo;Incidence;inducible Cre;Inflammation;insight;Investigation;Laboratories;Laboratory Study;Laminin;Learning;Location;lymphocyte trafficking;Macrophage;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Modeling;Molecular;Monitor;Mus;MYCN gene;Myeloid Cells;Neoplasm Metastasis;Neuroblastoma;Neuroendocrine Cell;patient subsets;Patients;Phenotype;premalignant;prevent;Process;Progressive Disease;Proteins;Proteoglycan;Proteolysis;Rag1 Mouse;recruit;Resected;Role;Signal Transduction;Site;Smooth Muscle;Solid;Solid Neoplasm;spheroids;Statistical Data Interpretation;Stromal Cells;Survival Rate;T-Lymphocyte;Testing;Tissue-Specific Gene Expression;transcriptomics;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;tumor-immune system interactions;tumorigenesis;tumorigenic;unsupervised clustering;versican;WT1 gene

PROJECT_TITLE: Cancer-associated fibroblasts and extracellular matrix remodeling in pediatric neuroblastoma


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Rehabilitation;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Greater understanding of the ways in which individuals with recover from Alcohol Use Disorder is a critical step to improving current treatment protocols. This project has the potential to provide insight into the behavior change process (clinical change points) during the course of AUD recovery and improve treatment outcomes by identifying which factors are important for initiating versus maintaining change during and after treatment.

PI_NAMEs: MAISTO, STEPHEN A;SCHLAUCH, ROBERT CHARLES (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Address;Adult;Affective;Aftercare;Age;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;American;Area;base;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral inhibition;Behavioral Mechanisms;Categories;Clinical;clinical decision-making;Clinical Markers;clinical practice;Clinical Research;clinically relevant;Cognitive;Communities;craving;Data Analyses;Data Collection;depression model;design;Diagnosis;Dimensions;Disease remission;DSM-V;effective intervention;Enrollment;follow-up;Frequencies;Goals;Grant;Heavy Drinking;heuristics;improved;Impulsivity;Individual;insight;interest;Interview;Knowledge;Literature;Measures;meetings;Modeling;Monitor;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;negative affect;novel;Outcome;partial recovery;Participant;Patient Recruitments;Pattern;person centered;Personal Satisfaction;Persons;Phase;primary outcome;Probability;Process;Psychotherapy;Recommendation;Recovery;recruit;Recurrence;Relapse;Research;response;ROC Curve;Self Efficacy;Severities;Structure;Subgroup;Survival Analysis;sustained recovery;Symptoms;Testing;Theoretical model;Therapeutic;therapy design;Time;treatment duration;Treatment outcome;treatment program;Treatment Protocols;treatment response

PROJECT_TITLE: Clinical Course of Alcohol Use Disorder Recovery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Public Health Relevance Statement Mental health disorders often involve disruptions of neuromodulatory systems. While oxytocin signaling has been implicated in autism, schizophrenia and other brain disorders, we know little about where and when oxytocin is released within the brain, or how it affects the circuits that regulate socio-spatial behaviors. Here, we take a multidisciplinary team approach to the synaptic, neuronal and circuit effects of oxytocin and the fundamental mechanisms by which this modulator affects parental care, adult social behavior, and cognitive function.

PI_NAMEs: TSIEN, RICHARD W (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Achievement;Adult;Affect;animal data;Animals;Area;autism spectrum disorder;Behavior;Behavior Control;Behavioral;Biological;Biophysics;Brain;Brain Diseases;BRAIN initiative;Brain region;career development;Caring;Central Nervous System;Child Rearing;cognitive function;Collaborations;commune;Communication;Communities;comparative;Complex;Computer Models;Core Facility;Crying;data curation;Data Science;Data Science Core;Decision Making;Development;Ecosystem;Ensure;Environment;experience;Extramural Activities;fitness;flexibility;Fostering;functional outcomes;Funding;Goals;Hippocampus;Hormones;Human;Hypothalamic structure;Image;improved;in vivo;Individual;Infant;innovation;interdisciplinary approach;Interdisciplinary Study;interest;Investments;Ion Channel;Knowledge;Lateral;Lead;Learning;life span;Literature;Mediating;medical schools;member;Memory;Mental disorders;Mentors;Methods;Molecular;multidisciplinary;Mus;neural;neural circuit;neuronal excitability;Neuronal Plasticity;Neurons;Neuropeptides;neuroregulation;next generation;offspring;Output;Oxytocin;Oxytocin Receptor;Pattern;peptide hormone;Peripheral;Physiological;Physiological Processes;Population;Postdoctoral Fellow;Property;public health relevance;Reagent;Reporting;repository;Reproduction;Research Personnel;Research Project Grants;Schizophrenia;selective attention;Signal Transduction;social;Social Behavior;social deficits;Social Dominance;Social Hierarchy;Social Interaction;social learning;Social Network;social relationships;sound;Source;Spatial Behavior;spatiotemporal;Stimulus;Structure;Students;success;supportive environment;Synapses;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;theories;Therapeutic;tool;Training;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: Oxytocin Modulation of Neural Circuit Function and Behavior


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Social Determinants of Health;Women's Health Research

PI_NAMEs: FROEMKE, ROBERT CROOKS (contact)

PROJECT_TERMS: Adult;Aggressive behavior;Animals;Area;Attention;autism spectrum disorder;Axon;Behavior;behavior change;Behavior monitoring;Behavioral;Behavioral Sciences;Birth;Brain;Brain region;Caring;cell type;Cells;Child Care;Child Rearing;Clinical;commune;Computer Models;Cues;Data;Data Science Core;Educational process of instructing;Electrophysiology (science);Ensure;Environment;Evaluation;experience;experimental study;Female;Foundations;Funding;Genetic study;Home;Hypothalamic structure;improved;In Vitro;in vivo;Infant;information processing;Infrastructure;Knowledge;Lactation;Lead;Learning;Life;male;Maternal Behavior;Maternal Physiology;Methods;Modeling;Molecular;Monitor;motherhood;Mothers;Mus;neglect;neural;neural circuit;Neurons;Neuropeptides;offspring;Oxytocin;Pair Bond;paraventricular nucleus;Parents;Partner in relationship;Pattern;Performance;Peripheral;Photometry;Physiological;Postpartum Period;Pregnancy;Prosencephalon;pup;recruit;Rewards;sex;Siblings;Signal Transduction;Single Parent;social;social anxiety;Social Behavior;Social Dominance;Social Environment;Social Interaction;Social Network;social structure;Spatial Behavior;supraoptic nucleus;Survival Rate;System;Temperature;theories;Time;tool;Video Recording;Work

PROJECT_TITLE: Functional organization and plasticity of the oxytocin system for single or communal parenting in mice


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

PI_NAMEs: LIN, DAYU  (contact)

PROJECT_TERMS: Address;Adult;Ally;Animals;Anterior;Automobile Driving;Avoidance Learning;Beds;Behavior;Behavior monitoring;Behavioral;bullying;Cell Nucleus;Cells;Chemosensitization;commune;Complex;Computer Models;Core Facility;Cues;Data;dyadic interaction;Elements;fighting;Funding;genetic manipulation;Goals;Human;Hypothalamic structure;Impairment;In Vitro;in vivo;Individual;insight;Learning;Maintenance;Memory;memory retention;Modeling;Molecular;Mus;neural;neural circuit;neuromechanism;optogenetics;OXT gene;Oxytocin;Oxytocin Receptor;parent project;Play;Predisposition;Privatization;Process;Receptor Cell;receptor expression;Receptor Signaling;response;Role;Services;Signal Transduction;social;social defeat;social group;Social Hierarchy;Social Interaction;social learning;social relationships;Social status;Source;success;supraoptic nucleus;Synapses;Testing;Theoretical model;Time;tool;transcriptomic profiling;Work

PROJECT_TITLE: The role of hypothalamic oxytocin signaling in defeat-induced social learning


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Protein production is a dynamic process that must be precisely regulated when cells are subjected to harmful conditions, which can lead to cellular malfunction, death, and diseases. The goal of this research is to understand the central role of ubiquitin in the control of protein production and define strategies to modulate this process.

PI_NAMEs: SILVA, GUSTAVO M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: aging process;Award;Biological Process;Cell Physiology;Cells;Cessation of life;Collaborations;Deubiquitination;Disease;Enzymes;Eukaryota;Failure;fighting;Future;Gene Expression;Goals;Individual;Interdisciplinary Study;Link;Mission;Modification;Molecular;molecular marker;National Institute of General Medical Sciences;Neurodegenerative Disorders;Oxidative Stress;Pathway interactions;Polyubiquitin;Post-Translational Protein Processing;Process;Production;programs;Protein Biosynthesis;protein degradation;protein expression;Proteins;Proteomics;Reaction;Regulation;Research;Resistance;response;Ribosomes;Role;Shapes;Site;Source;Stress;three dimensional structure;tool;Translational Regulation;Translations;tumor progression;Ubiquitin;Ubiquitination;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Dissecting the roles of ubiquitin in translation control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Lung;Obesity;Orphan Drug;Prevention;Pulmonary Fibrosis;Rare Diseases;Sarcopenia

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is an increasingly prevalent chronic lung disease with no available cure; frailty affects 50% of IPF patients, and is associated with increased severity of illness in response to acute insults, which are the most common cause of death in IPF. We identified that visceral adipose tissue is a risk factor for frailty and propose to investigate potential mechanisms linking visceral adipose tissue and frailty, as modifiable risk factors for morbidity and mortality in this growing patient population. Our findings may lead to novel therapies and clinical trials evaluating the role of existing medications in the prevention and treatment of frailty in IPF.

PI_NAMEs: ANDERSON, MICHAELA RESTIVO (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Adipose tissue;Adrenal Cortex Hormones;Adult;Affect;Aging;American;androgenic;antagonist;Arrhythmia;Award;Biolectric Impedance;Biological Assay;Biology;Biometry;Body Composition;Body mass index;career;career development;Cause of Death;Central obesity;Cessation of life;Chronic lung disease;circulating biomarkers;Clinical Investigator;Clinical Trials;cohort;Communities;Complex;Conduct Clinical Trials;Data;Deposition;design;Development;Development Plans;Disease;Disease Progression;Down-Regulation;Endocrine system;Epidemiology;Etiology;Evaluation;Exercise;Family;FDA approved;fibrotic interstitial lung disease;frailty;Functional disorder;Funding;Future;Goals;Grant;growth hormone deficiency;health related quality of life;High Prevalence;HIV;hormone analog;Hormone secretion;Hospitalization;human old age (65+);idiopathic pulmonary fibrosis;Inflammation;Infrastructure;Injury;Insulin-Like Growth Factor I;Interleukin-1 beta;Interleukin-1 Receptors;Interleukin-6;Interstitial Lung Diseases;Intramuscular;Investigation;K-Series Research Career Programs;Knowledge;Lead;Life;Link;Lung Diseases;Lung Transplantation;Machine Learning;Measurement;Mediator;Mentors;Mentorship;modifiable risk;Morbidity - disease rate;mortality;muscle form;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Neurosecretory Systems;novel;novel therapeutics;Obesity;older adult;Outcome;participant enrollment;Pathway interactions;patient oriented;patient oriented research;patient population;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Pilot Projects;Pneumonia;Predisposition;Prevalence;prevent;Prevention;prospective;Prospective cohort;Prospective, cohort study;Protocols documentation;Pulmonary Fibrosis;pulmonary rehabilitation;reduced muscle mass;Research;research and development;Research Priority;respiratory;response;Risk;Risk Factors;Role;sarcopenia;sarcopenic obesity;Selection Criteria;Series;Serum;Severity of illness;Skeletal Muscle;skill acquisition;Societies;Somatotropin;Somatotropin-Releasing Hormone;Steroids;Structure of parenchyma of lung;Subgroup;Syndrome;systemic inflammatory response;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic target;TNF gene;Training;translational approach;translational scientist;Transplantation;Tumor Necrosis Factor Receptor;Variant;Visceral;Work

PROJECT_TITLE: Role of visceral adipose tissue in frailty among patients with Idiopathic Pulmonary Fibrosis


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Economic empowerment (EE) interventions have demonstrated substantial promise in reducing HIV-related risk-taking behaviors, and improving ART treatment adherence and mental health outcomes. Yet, scaling EE interventions has been a challenge, signaling the need to identify and test scale-up strategies and examine determinants of implementation and sustainment. Using a two-arm Hybrid III effectiveness-implementation cluster randomized clinical trial, the Bridges2Scale study will address a critical challenge, which is: how to best support the implementation, scale-up, and sustainment of EE interventions, which have been proven to be highly efficacious in improving youth-focused HIV prevention, care, and support outcomes, but are yet to be widely scaled up.

PI_NAMEs: NAKASUJJA, NOELINE ;POWELL, BYRON JAMES;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Affect;Africa South of the Sahara;Age;AIDS prevention;arm;Behavior;Businesses;Caring;Clinical effectiveness;cohesion;Communities;community partners;comparative cost effectiveness;Contracts;cost;cost comparison;cost effectiveness;design;Development;economic evaluation;Economics;Education;Educational Status;Effectiveness;effectiveness evaluation;empowerment;Ensure;Evidence based practice;experience;Family;financial literacy;Foundations;Funding;Future;Government;Health;HIV;HIV Seronegativity;Household;Hybrids;implementation determinants;implementation outcomes;implementation process;implementation strategy;implementation/effectiveness;improved;Incentives;Income;Intervention;Interview;Investments;Kenya;Maps;meetings;member;Mental Health;Mentorship;Methods;Modification;Outcome;Outcome Measure;Participant;Penetration;Perception;Persons;post intervention;pre-exposure prophylaxis;Preparation;Prevalence;primary outcome;Process;Protocols documentation;psychosocial outcome;public-private partnership;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Research Priority;Resource-limited setting;Risk;Risk Taking;Savings;scale up;Schools;sexual risk taking;Signal Transduction;Site;standardize measure;Structure;Students;System;Testing;theories;Training;transmission process;treatment adherence;Uganda;Underserved Population;United States National Institutes of Health;Viral;Youth

PROJECT_TITLE: Bridges2Scale: Testing implementation strategies for an intervention among young people affected by AIDS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

PROJECT_TERMS: Address;Affect;Aggressive behavior;antagonist;Area;attenuation;Behavior;Behavior Control;Behavioral;Biological;Biophysical Process;Brain;Brain region;Cations;Cellular biology;Chemosensitization;Child Rearing;combinatorial;Computer Models;cyclic-nucleotide gated ion channels;Data;Decision Making;Dependence;Disinhibition;Distal;Dorsal;Electrophysiology (science);entorhinal cortex;Esthesia;Event;Feedback;Fire - disasters;G-Protein-Coupled Receptors;Generations;Goals;hippocampal pyramidal neuron;Hippocampus;Hour;Hypothalamic structure;in vivo;interest;Interneurons;Interruption;inward rectifier potassium channel;Ion Channel;Lateral;Lead;Measures;meetings;Membrane;Membrane Potentials;Memory;memory recognition;Mental Depression;millisecond;Modeling;Molecular;Molecular Conformation;Neocortex;neocortical;neural;neural circuit;neuronal cell body;Neurons;Neuropeptides;neuropsychiatric disorder;Neurotransmitter Receptor;novel;operation;Output;OXT gene;Oxytocin;Oxytocin Receptor;Pair Bond;Population;postsynaptic;Potassium Channel;Receptor Signaling;Regulation;Resistance;response;Rest;restraint;segregation;sensor;Sensory;Shapes;Signal Transduction;Site;social;Social Behavior;social competition;Social Controls;social defeat;Social Hierarchy;Structure;Synapses;synaptic depression;Synaptic Transmission;synergism;Testing;Time;tool;transmission process;Tube;voltage

PROJECT_TITLE: Oxytocin regulation of ion channels and canonical circuit operations


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE – OVERALL Aging is the most important risk factor for human chronic diseases, including type 2 diabetes, cardiovascular disease, cancer and neurodegeneration. Here we propose to continue our new approach for developing therapies for these diseases. Rather than focusing on individual diseases, we focus on the genetic differences between successfully aged, healthy centenarians and control individuals with no family history of extreme longevity. Based on results from the previous project period, many of such genetic differences involve physiological processes that have previously been shown to be involved in extreme longevity of model organisms. Using extensive genetic resources, including whole exome sequences of our ~ 700 centenarians (in the process of significant expansion), we aim to discover novel genetic variants involved in healthy aging and longevity. We will then validate these human genetic variants in other centenarian cohorts, subsequently functionalize the top candidates in vitro and in mice in vivo, and develop drug screening assays for these variants. This genes-to-drugs collaborative project is the first to use the genetics of the very rare individuals aged over a hundred in relatively good health to identify therapeutic approaches for targeting aging itself rather than its composite diseases for preventing, delaying onset and progression, and possibly even reverting many of the multiple age-related diseases.

PI_NAMEs: BARZILAI, NIR J;ROBBINS, PAUL D.;VIJG, JAN  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;age acceleration;age related;age-related disease;aged;Aging;aging mechanism;aging related;Alzheimer's disease pathology;appropriate dose;Biological Assay;Candidate Disease Gene;Cardiovascular Diseases;Cell Aging;Cell model;Cells;Centenarian;Chronic;Chronic Disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;college;Communities;Data;data integration;data portal;Data Set;data sharing;Development;Diabetes Mellitus;Disease;DNA Damage;DNA Resequencing;drug development;drug discovery;Drug Kinetics;Drug Screening;Drug Targeting;exome;extend lifespan;extreme human longevity;Family history of;FDA approved;fly;Foundations;FOXO3A gene;Freezing;Funding;FVB Mouse;Genes;Genetic;genetic analysis;genetic association;genetic information;genetic resource;Genetic Screening;genetic variant;Genome;Genomics;Goals;Growth;Health;healthspan;healthy aging;high throughput screening;Human;human disease;Human Engineering;Human Genetics;human pluripotent stem cell;Hybrids;IGF1R gene;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;interdisciplinary approach;Intervention;Intervention Studies;late life;Lead;Leadership;Link;Longevity;Longevity Pathway;MADH3 gene;Malignant Neoplasms;Medicine;Metabolism;model organism;Modeling;Morbidity - disease rate;mouse genetics;mouse model;multiple chronic conditions;Mus;Natural Products;Nematoda;Nerve Degeneration;new therapeutic target;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;old mice;Outcome;p65;Pathway interactions;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological Processes;prevent;Process;programs;promote resilience;rare variant;Regimen;repository;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Role;Route;screening;small molecule;Specificity;stem;stem cell biology;stressor;success;Testing;Therapeutic;therapeutic target;therapy development;TNFRSF5 gene;transcriptome sequencing;transcriptomics;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Genetic variant-based drug discovery targeting conserved pathways of aging


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Gender minority youth face a disproportionately high risk for serious mental health problems relative to cisgender youth, an inequity that is exacerbated by the dearth of mental health providers trained in gender- affirming care. The proposed research will develop and pilot test a scalable, mechanism-driven, user- centered, and community-engaged training to increase mental health providers’ use of gender-affirming practices. The intervention has the potential to improve the mental health of gender minority youth, and the identified mechanisms may be generalizable to provider training interventions for other consumer populations facing mental health inequities.

PI_NAMEs: PRICE, MAGGI  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adoption;Adult;Advisory Committees;Affect;Age;Anxiety;Attitude;behavior change;Behavior Therapy;Behavioral;Birth;Boston;career;career development;Caregivers;Caring;Case Series;Characteristics;Child;cisgender;Clinic;Clinical;Collaborations;college;Communities;community advisory board;community engaged research;Competence;Coupled;Data;design;Development;Diagnosis;Discrimination;Distal;Educational Curriculum;Educational Intervention;effective intervention;Effectiveness;Electronics;Ensure;Environment;Equity;experience;Face;Family;feasibility trial;Feedback;Focus Groups;follow up assessment;Future;gender affirmation;gender affirming care;Gender Identity;gender minority;gender minority youth;Goals;health care settings;health inequalities;Health Personnel;health practice;high risk;implementation science;Improve Access;improved;Inequity;Internships;Intervention;intervention refinement;Knowledge;Lead;Medical;meetings;member;Mental Depression;Mental Health;Mental Health Services;mental training;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;mHealth;minority healthcare;National Institute of Mental Health;Outcome;Parents;Participant;peer;Phase;physical assault;pilot test;pilot trial;Population;post-traumatic stress;Practice Guidelines;Price;primary outcome;programs;prototype;Provider;provider behavior;public health relevance;Race;Readiness;Recommendation;Reporting;Research;Resources;satisfaction;Self Efficacy;service engagement;sex assigned;Sexual and Gender Minorities;sexual assault;skills;Stereotyping;Stigmatization;success;Suggestion;suicidal;Suicide;Suicide attempt;Surveys;symptomatology;Technology;Testing;therapy design;therapy development;Thinking;Training;trauma exposure;United States National Institutes of Health;usability;user centered design;verbal;Youth

PROJECT_TITLE: Development of a Training Intervention to Improve Mental Health Treatment for Gender Minority Youth

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


PHR: Project Narrative – Core A The overall goals of Core A, the Administrative Core of the proposed U19 project “Genetic variant-based drug discovery targeting conserved pathways of aging” are to provide general scientific, programmatic and fiscal leadership, facilitate lines of communication between the different researchers involved in the U19, maintain coherence in the U19's overall and long-range goals, report the results obtained to the NIA, and ensure that resources resulting from the research will benefit the scientific community.

PI_NAMEs: VIJG, JAN  (contact)

PROJECT_TERMS: Affect;age-related disease;Aging;aging mechanism;Biological Assay;Biology of Aging;Cell Aging;Cells;Centenarian;Chairperson;cohort;Cohort Studies;college;Communication;Communities;Data;data integration;data resource;Data Set;data sharing;Databases;DNA Repair;drug development;drug discovery;Drug Screening;Drug Targeting;Ensure;exome;exome sequencing;extreme human longevity;Funding;Genes;Genetic;genetic analysis;genetic information;genetic resource;Genetic Screening;genetic variant;Genome;genomic data;Genomics;German population;Geroscientist;Goals;Grant;Health;healthspan;healthy aging;high throughput screening;Human;Human Genetics;Human Resources;induced pluripotent stem cell;Institution;interdisciplinary approach;Intervention;late life;Leadership;Location;Longevity;Medicine;Metabolism;Minnesota;Monitor;mouse genetics;mouse model;New England;new technology;New York;novel;Pathway interactions;Phenotype;programs;promote resilience;Qualifying;Reagent;recruit;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Scientific Evaluation;screening;small molecule;sound;stem cell biology;Technology;Testing;Tissue Sample;tool;United States National Institutes of Health;Universities;Validation;Variant

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

PI_NAMEs: BUZSAKI, GYORGY  (contact)

PROJECT_TERMS: Acetylcholine;Address;Affect;Anatomy;Animals;Anxiety;Area;Arousal;Behavior;Behavioral;Blood Pressure;Blood Vessels;Brain;Brain region;Cardiac;Caring;Cell Nucleus;cell type;Cells;Central Nervous System;Child Rearing;Classification;Collaborations;collaborative environment;Communication;Computer Models;cooperative study;Coupling;Data;Data Science Core;Dedications;Discipline of Nursing;Dorsal;Electrophysiology (science);Endocrine system;Ensure;experience;experimental study;Feedback;feeding;Fire - disasters;Goals;Heart Rate;Hippocampus;Homeostasis;Hypothalamic Hormones;Hypothalamic structure;Image;In Vitro;in vivo;Individual;Kidney;Knowledge;Laboratories;Lactation;Literature;Locomotion;magnocellular;Mammals;Measures;Memory;Methods;Molecular;Mothers;Mus;Neocortex;neocortical;neural circuit;Neuromodulator;Neurons;neuroregulation;next generation;non rapid eye movement;novel;novel strategies;optogenetics;Organ;Output;Oxytocin;paraventricular nucleus;parvocellular;Pathologic;Pathway interactions;Pattern;Physiological;Physiological Processes;Population;Population Characteristics;Postdoctoral Fellow;Posterior Pituitary Gland;Productivity;Proliferating;Property;receptive field;Regulation;REM Sleep;response;Role;sensor;Signal Transduction;Sleep;sleep pattern;Slice;social;Social Behavior;social contact;Social Hierarchy;Social Interaction;social learning;spatiotemporal;student training;supraoptic nucleus;Synaptic Transmission;System;Testing;Thalamic structure;thymocyte;Thymus Gland;Tissue-Specific Gene Expression;tool;Water;Work

PROJECT_TITLE: Neural circuits regulating brain-wide effects of oxytocin neurons


NIH_SPENDING_CATS: Aging;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The proposed data core is relevant to public health because a web data portal and novel computational methods will be developed to tackle the genetic bases and molecular mechanisms of human aging related to common human diseases and its targets for developing anti-aging therapies. The web data portal will also be used to disseminate the data to the larger research community. The proposed research is directly relevant to the NIA mission in that it pertains to developing fundamental knowledge that will help reduce the burdens of human disabilities associated with advanced age.

PI_NAMEs: ZHANG, ZHENGDONG  (contact)

PROJECT_TERMS: Affect;age related;age-related disease;aged;Aging;aging gene;aging mechanism;aging related;anti aging;anti aging drug;base;Biological;Cardiovascular Diseases;Cell model;Cell Nucleus;Cells;Centenarian;cohort;Communities;computerized data processing;Computing Methodologies;Consultations;Data;data access;Data Analyses;data integration;data portal;Data Set;data sharing;data standards;data submission;data warehouse;Databases;Dedications;design;disability;Disease;Disease Resistance;drug development;drug discovery;Drug Targeting;Elderly;epigenetic marker;Etiology;Family history of;gene network;Genes;Genetic;genetic variant;Genome;genome sequencing;genomic data;Genotype;Geographic Locations;gerotherapeutic;global health;Goals;Grant;Health;healthspan;healthy aging;heterogenous data;Human;human disease;Human Genetics;human induced pluripotent stem cells;Individual;insight;Internet;Knowledge;late life;life span;Longevity;Malignant Neoplasms;Methods;Mission;model organism;Modeling;Molecular;mouse model;multiple omics;Mus;Nerve Degeneration;Network-based;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;Phenotype;prevent;Process;programs;Public Health;rare variant;relational database;Research;Research Personnel;Research Project Grants;Risk Factors;Role;Services;small molecule;synergism;System;Testing;therapeutic development;therapeutic target;therapy development;transcriptome sequencing;treatment strategy;user-friendly;Variant;web page;web portal;web site;whole genome;Work

PROJECT_TITLE: Data Integration and Sharing Core


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Neurosciences

PROJECT_TERMS: Acceleration;Achievement;Advisory Committees;Area;Awareness;Behavior;Biological;Brain;BRAIN initiative;Budgets;career;career development;cell type;Cities;Collaborations;Communication;Communities;Complex;Computer Models;Connexins;Core Facility;data management;Data Management Resources;Data Science;Data Science Core;data sharing;Development Plans;diversity and inclusion;Doctor of Philosophy;doctoral student;Ensure;Environment;equity, diversity, and inclusion;Event;experience;Extramural Activities;Faculty;Feedback;Fellowship;Fostering;Funding;Future;Goals;graduate student;Health;Health Science Library;Human Resources;Individual;Information Dissemination;Institution;interest;International;Interview;Job Application;Knowledge;Leadership;Learning;medical schools;meetings;member;Mentors;Mentorship;Molecular;Museums;neural circuit;Neurons;neuroregulation;Neurosciences;New York City;Occupational activity of managing finances;Occupations;operation;outreach;outreach program;Oxytocin;Paper;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Productivity;programs;Progress Reports;Publications;Publishing;Recording of previous events;Recruitment Activity;Reporting;Research;Research Personnel;Resources;Role;Schedule;Schools;Scientist;Societies;Solid;spatial memory;Structure;Students;success;summer research;symposium;synergism;tool;Training;Training Programs;Twitter;undergraduate student;Underrepresented Minority;United States National Institutes of Health;web site;Work


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Hair follicle stem cells (HFSCs) are multipotent epithelial stem cells that fuel the production of hair follicles throughout the life of an organism. We have recently identified that the key chromatin regulator, the Polycomb complex, not only plays a critical role in HFSCs but also exerts its function via a novel mechanism of gene regulation. By dissecting the molecular mechanisms of Polycomb-mediated regulation of HFSCs, we aim to gain insight into the regulation of HFSC during normal homeostasis as well as uncover processes that go awry in human diseases such as cancer.

PI_NAMEs: EZHKOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Ablation;Acceleration;Adult;Aging;Animals;Biochemical;Biological Process;bone morphogenetic protein receptors;ChIP-seq;Chromatin;comparison control;Complex;Cues;Data;daughter cell;derepression;Disease;Down-Regulation;epithelial stem cell;Equilibrium;Experimental Genetics;experimental study;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Growth;Hair;Hair follicle structure;Homeostasis;Human;human disease;in vivo;inhibitor;insight;Knockout Mice;Lead;Life;loss of function;Malignant Neoplasms;Mediating;Molecular;multipotent cell;Multipotent Stem Cells;Mus;Mutate;Natural regeneration;novel;Organism;Phenotype;Play;Polycomb;PRC1 Protein;premature;Process;Production;Proliferating;Regulation;Reporting;Repression;Rest;Role;Signal Transduction;Skin;Skin Cancer;skin disorder;stem cells;System;Testing;Transcription Coactivator;transcriptome sequencing;WNT Signaling Pathway

PROJECT_TITLE: Toward Understanding the Role of the Polycomb Complex in Skin Control


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Physical Activity;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Expanding opportunities to learn chronic pain self-management skills is a major public health priority, yet we lack evidence for successful delivery models in diverse and underserved older populations. We will test a program in which community health workers teach pain self-management skills to primarily African American older adults in a socioeconomically disadvantaged urban community. Because this group is at disproportionately high risk for poor functioning due to pain, this research could substantially reduce pain- related disparities and enhance population health.

PI_NAMEs: JANEVIC, MARY ROSE (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Accelerometer;Address;Adult;adult of color;Affect;African American;Age;age acceleration;aged;Aging;Behavior;Behavioral;Caring;chronic pain;Cities;Cognitive;Color;Communities;Community Health Aides;comparison control;Computers;cost;COVID-19;COVID-19 impact;Data;Disadvantaged;Discipline of Nursing;Disparity;economic disparity;Economics;Educational process of instructing;efficacy trial;Enrollment;environmental stressor;evidence base;Evidence based intervention;Face;Frontline worker;Goals;group intervention;Health;health disparity;Health system;high risk;Housing;Human;impression;improved;Income;Inequity;innovation;Intervention;intervention effect;intervention participants;Knowledge;Learning;marginalization;Mediating;Mediator;Methods;mHealth;Michigan;Modeling;Monitor;Musculoskeletal Pain;Needs Assessment;novel;older adult;Older Population;Online Systems;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;Pain Research;pain self-management;pain-related disability;Participant;Persons;Pharmaceutical Preparations;Physical activity;Physical Medicine;Physical Rehabilitation;Pilot Projects;pilot test;Population;population health;Positioning Attribute;Prevalence;primary outcome;Process;programs;psychologic;psychosocial stressors;Public Health;public health priorities;racial disparity;Racial Segregation;Randomized, Controlled Trials;remote delivery;Reporting;Research;Resources;Risk;Role;secondary outcome;Self Efficacy;self-management program;Services;sex;skills;Social Distance;social health determinants;Social Mobility;socioeconomic disadvantage;socioeconomic disparity;Standardization;stem;stressor;Structural Racism;Sustainable Development;Technology;telephone based;telephone delivery;telephone session;Testing;Therapeutic;tool;Training;Transportation;underserved area;underserved community;Urban Community;urban setting;usual care arm;virtual;Vulnerable Populations;wearable device

PROJECT_TITLE: An Efficacy Trial of Community Health Worker-Delivered Chronic Pain Self-Management Support for Vulnerable Older Adults

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our pharmacologically aged genotype-specific ARMS2-HTRA1 RPE cell lines will be used to identify the alleles responsible for age related macular degeneration.

PI_NAMEs: MCFALINE-FIGUEROA, JOSE LUIS;TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 10q;Address;Adult;age related;Age related macular degeneration;aged;Alleles;Anti-Inflammatory Agents;Antioxidants;Area;Biology of Aging;cell age;Cell Line;Cell Proliferation;Cells;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complement Factor H;Cultured Cells;Disease;disease model;disease phenotype;embryo cell;Environment;Etiology;experimental study;Eye;Foundations;Genes;Genetic Risk;genome wide association study;genomic locus;Genomics;Genotype;high risk;High temperature of physical object;Human Genome;Immune;Immunologics;Individual;induced pluripotent stem cell;Inflammatory;innovation;insertion/deletion mutation;Intervention;Late-Onset Disorder;Link;Mediating;Metabolic;Methods;Microglia;Modeling;Molecular Biology;Mutation;neurotransmission;new therapeutic target;New York;older adult;Outcome;Oxidative Stress;Pathogenesis;Patients;Peptide Hydrolases;pharmacologic;Predisposition;promoter;Recording of previous events;repaired;Research;Retinal Diseases;Risk;Risk Factors;risk variant;Serine;Single Nucleotide Polymorphism;SOD2 gene;stem cells;Structure of retinal pigment epithelium;Testing;therapeutic target;Transcript;Variant

PROJECT_TITLE: Identification of the specific risk allele responsible for oxidative stress in ARMS2/HTRA1-related AMD


PHR: PROJECT NARRATIVE The proposed Project 1 is relevant to public health because we will study centenarian cohorts for better understanding of the genetics of extreme human longevity and use this knowledge to identify novel therapeutics that slow or mitigate aging and all associated diseases. The proposed research is directly relevant to the NIA mission in that it pertains to developing fundamental knowledge that will help reduce the burdens of human disabilities associated with advanced age.

PROJECT_TERMS: Affect;Age;Age related pathologies;age-related disease;aged;Aging;aging mechanism;aging population;American;ATAC-seq;Biological Assay;Biological Process;Blood;Blood Cells;burden of illness;causal variant;cell type;Cells;Centenarian;Chronic Disease;Clinical Trials;cohort;comparison control;Complex;Country;Data Set;disability;Disease;DNA Sequence Alteration;drug discovery;Drug Screening;Drug Targeting;Economics;Elasticity;Elderly;Environmental Risk Factor;exome;exome sequencing;extreme human longevity;Family history of;follower of religion Jewish;Frequencies;functional gain;Funding;Gene Frequency;gene regulatory network;Genes;Genetic;genetic architecture;Genetic Epistasis;Genetic Risk;genetic variant;Genome;genome wide association study;gerotherapeutic;global health;Goals;Health;Healthcare Systems;healthy aging;Heritability;Human;human old age (65+);Individual;insight;Intervention;Knowledge;life span;Longevity;machine learning framework;Maintenance;Measures;Methods;Mission;model organism;Modeling;Morbidity - disease rate;mouse model;multi-ethnic;Mutagens;Mutation;novel strategies;novel therapeutics;older adult;Older Population;Organism;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Population;Population Study;prevent;Public Health;rare variant;Regulatory Pathway;Research;Risk;Risk Factors;Signal Pathway;single molecule;single-cell RNA sequencing;statistics;Stress;success;Testing;therapeutic target;therapy development;Tissues;trait;transcription factor;United States;Untranslated RNA;Variant;virtual

PROJECT_TITLE: Genetics of extreme human longevity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Neurosciences

PI_NAMEs: SURKIS, ALISA  (contact)

PROJECT_TERMS: Address;analysis pipeline;animal data;Animals;archive data;Archives;arm;Behavior;Behavior monitoring;Behavioral;Biomedical Research;BRAIN initiative;Brain Stem;Catalogs;Cells;Charge;Collaborations;Collection;Communities;computational neuroscience;Controlled Vocabulary;Core Facility;Data;Data Analyses;data archive;Data Collection;Data Discovery;data repository;data reuse;Data Science Core;data science management;Data Set;data sharing;Deposition;Development;Electrodes;Elements;Ensure;experience;experimental study;extracellular;Extramural Activities;Faculty;FAIR principles;Fiber;flexibility;Foundations;Gene Expression Profiling;Goals;Health Science Library;Human;Human Resources;Image;improved;In Vitro;in vivo;Infrastructure;innovation;Lead;Librarians;Librarianship;Machine Learning;medical schools;member;Metadata;Modeling;Molecular Profiling;movie;Mus;neural;neural circuit;Neurosciences;OXT gene;Oxytocin;Photometry;Physiological;Positioning Attribute;repository;Research Personnel;Resources;Services;Social Behavior;Solid;spatial memory;Standardization;Structure;success;symposium;System;tool;Training;two-photon;United States National Institutes of Health;United States National Library of Medicine;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE If we validate an SLT treatment strategy that extends the duration of medication-free disease control, we move one step closer to the possibility of a drop-free lifetime for our patients. Delaying the need for medications by 3, or 5, or 7 years not only confers all the benefits of medication-freedom during this period (which will be all that many patients would need in their lifetimes)—it also allows time for development of safer and more effective drugs dosed infrequently via sustained-release delivery systems, as well as better surgical options, for patients whose lifespans exceed SLT responsiveness. Thus, a new treatment paradigm consisting of SLT, then sustained-release medications, then surgery, could offer the majority of glaucoma patients the very real possibility of a drop-free lifetime of therapy.

PI_NAMEs: REALINI, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Adherence;aqueous;Argon;Cell Physiology;Cells;Clinical Research;comparative efficacy;Complex;Cornea;Data;Data Set;design;Development;disorder control;Dose;Drops;Effectiveness;Eye;Face;Failure;follow-up;Free Will;Freedom;Glaucoma;glaucoma surgery;Goals;Health;high risk;Human;Impairment;Inflammation;Italy;Laser Surgery;Lasers;life span;Light;Maintenance;Medical;minimally invasive;Molecular;Multi-Institutional Clinical Trial;Newly Diagnosed;novel therapeutics;Ocular Hypertension;Open-Angle Glaucoma;Operative Surgical Procedures;Outcome;Participant;Patient Compliance;Patients;Pattern;Pharmaceutical Preparations;Physiologic Intraocular Pressure;preservation;prevent;primary outcome;procedure safety;Process;Protocols documentation;Randomized;randomized trial;randomized, clinical trials;Regimen;response;Retreatment;Safety;Series;Shapes;Site;Specific qualifier value;Spottings;Survival Rate;Synthetic Prostaglandins;System;Therapy trial;Time;tissue culture;Titrations;Trabecular meshwork structure;Trabeculectomy;treatment strategy;Vision

PROJECT_TITLE: Clarifying the Optimal Application of SLT Therapy (COAST)


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth;Underage Drinking

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative This project aims to develop engagement strategies translated from behavioral economics (i.e., episodic future thinking, reciprocity) to increase engagement of Black college men (BCM) who consume alcohol in a mindfulness mobile health (mHealth) app. We will investigate the feasibility and acceptability of translating and integrating strategies drawn from behavioral economics in an mHealth intervention to support engagement in mHealth mindfulness (proximal outcome) and reduction in alcohol use (distal outcome) in BCM who consume alcohol. The proposed training and research project will build on the PI’s current skills in cross-sectional and qualitative research with racial minority populations and assist in the PI’s development as an independent researcher whose goal is to improve alcohol outcomes for BCM.

PI_NAMEs: MARKS, LAURA MICHELLE REID (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Address;aged;Alcohol consumption;alcohol misuse prevention;alcohol related consequences;alcohol use disorder;Alcohols;automobile accident;Baseline Surveys;Behavior;Behavior Therapy;Behavioral;behavioral economics;binge drinking;Black Populations;Black race;black women;career development;Cellular Phone;Clinical;college;Consumption;coping;Data;Development;Distal;drinking;drinking behavior;Ecological momentary assessment;Educational workshop;emerging adult;Ensure;Environment;experience;feasibility testing;Focus Groups;Future;Gifts;Goals;habituation;handheld mobile device;Health;health disparity;Heavy Drinking;high risk drinking;Hour;improved;Incentives;Individual;Institution;Intervention;Interview;Learning;Legal;meetings;men;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mHealth;mhealth interventions;mindfulness;mindfulness intervention;Mobile Health Application;Modeling;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Participant;peer;Phase;Populations at Risk;Preparation;programs;Qualitative Research;racial minority population;Randomized;randomized trial;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;response;retention rate;Rewards;satisfaction;Scientist;skills;Statistical Data Interpretation;Stress;stress management;stress reduction;Students;symposium;Text;theories;therapy development;Thinking;Time;Training;training project;Translating;Translations;United States;United States National Institutes of Health;university student;Woman

PROJECT_TITLE: Translating Behavioral Economics Strategies to Culturally Tailor a Mobile Health Mindfulness Intervention to Reduce Risky Drinking Behaviors in Black College Student Men

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: A predoctoral T32 training program is proposed for the purpose of augmenting the research workforce in Alzheimer’s Disease, related dementias, and other neurodegenerative disorders. The training initiative is named the South Texas Alzheimer’s and Neurodegenerative Disorders Training Program: STAND TP. STAND TP is hosted by UT Health San Antonio (UTHSA), a Hispanic Serving Institution which plays a dominant role in health-care delivery to the residents of San Antonio and greater South Texas, the majority of whom are Hispanic.

PI_NAMEs: CAVAZOS, JOSE E;FOX, PETER THORNTON (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's Disease;Neurodegenerative Disorders;South Texas;Training Programs

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Neurosciences

PI_NAMEs: CHAO, MOSES VICTOR (contact)

PROJECT_TERMS: Agonist;antagonist;Antibodies;Area;Behavior;Behavioral;Biochemistry;blood-brain barrier crossing;Brain;BRAIN initiative;cell type;Central Nervous System;Chemistry;Communication;Communities;Core Facility;Data;Development;Dissection;Electron Microscopy;Elements;Ensure;Epitopes;Extramural Activities;Fc Receptor;Gene Expression;Generations;Genetic;genetic approach;Genetic Models;Goals;Hippocampus;Hypothalamic structure;improved;In Vitro;in vivo;Individual;Infusion procedures;innovation;International;Intranasal Administration;Letters;Ligands;loss of function;manufacturing scale-up;medical schools;member;Methods;Microtus;Molecular;Monitor;Monoclonal Antibodies;Mouse Cell Line;mouse model;Mus;neural circuit;Neuromodulator;Neurons;neuroregulation;novel;Optics;Organism;Oxytocin;Oxytocin Receptor;peptide hormone;Peptide Signal Sequences;Peptides;Peripheral;Physiological;Population;Postdoctoral Fellow;Production;Rattus;Reagent;receptor;Receptor Signaling;Research Support;Resources;response;Rodent;Role;sensor;Signal Transduction;Social Behavior;Songbirds;Spatial Behavior;spatiotemporal;Specificity;Study models;System;Testing;tissue fixing;Tissues;tool;Training;transcriptome;Validation;Venus;Viral;Visualization;Work

PROJECT_TITLE: Molecular Tools Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative  The predominant and commonly applied therapeutic strategies in treating human diseases are unidirectionally inhibiting or stimulating the affected biological processes. However, no drugs have successfully prevented, reversed or even modified the disease course with the strategies for many chronic and slow progression diseases like Alzheimer’s Disease and amyotrophic lateral sclerosis. This TRA project will pioneer the innovative homeostatic restoration of the affected signaling as a novel treatment paradigm to overcome this significant and formidable challenge.

PI_NAMEs: LU, QUN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acceleration;Acetylcholinesterase Inhibitors;Affect;Agonist;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyotrophic Lateral Sclerosis;antagonist;anti-depressive agents;Apolipoprotein E;Area;aripiprazole;autism spectrum disorder;Biological Process;Brain Diseases;Brain region;Buprenorphine;C9ORF72;Cellular biology;Chronic;Chronic Disease;Classification;Clinical;Complex;Computer Models;dementia risk;Disease;Disease Progression;Down's Syndrome;Drug Addiction;drug development;endoplasmic reticulum stress;Equilibrium;Event;Excitatory Amino Acid Antagonists;excitotoxicity;Exhibits;Family;FDA approved;Future;Generations;Genes;Goals;Human;human disease;inhibitor;innovation;insight;Institution;interdisciplinary approach;Learning;Medicine;Memantine;Memory;Monomeric GTP-Binding Proteins;mouse genetics;mouse model;Mus;neural;Neurodegenerative Disorders;Neurosciences;neurotoxic;novel;novel therapeutics;Pain;Pathogenesis;Pesticides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;presenilin;prevent;Process;protein aggregation;Protein Inhibition;protein protein interaction;protein TDP-43;Proteins;rab GTP-Binding Proteins;restoration;rho;rho GTP-Binding Proteins;Schizophrenia;Signal Pathway;Signal Transduction;small molecule;spatiotemporal;Subutex;superoxide dismutase 1;Synapses;Tacrine;tau Proteins;Testing;Therapeutic;trafficking;United States National Institutes of Health;Validation

PROJECT_TITLE: Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative

PHR: Narrative Recent advances in human genetics and genomics provide novel opportunities for the identification and validation of drug targets. Aging is a major risk factor for many chronic diseases, including cardiovascular disease, neurodegenerative diseases and a wide range of cancers. Interventions targeting the underlying process of aging are expected to provide significant benefits to human health and substantially reduce the social and economic costs associated with age-related disease and frailty. The experiments outlined in this proposal are aimed at identifying functional genetic factors associated with human healthy aging and extreme longevity for therapeutic modulation to improve human health span and lifespan.

PROJECT_TERMS: age related;Age related pathologies;Age-associated memory impairment;age-related disease;Aging;aging mechanism;aging process;aging related;Alzheimer's Disease;Alzheimer's disease risk;Attenuated;Biochemical;Biological;Biological Assay;Cardiovascular Diseases;causal variant;Cell Aging;Cell Differentiation process;Cell model;cell type;Cellular Assay;Centenarian;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cognitive;Collaborations;Data;dietary;drug discovery;Drug Targeting;economic cost;epigenomics;exome sequencing;experimental study;extend lifespan;fly;follower of religion Jewish;frailty;FRAP1 gene;Frequencies;Gene Expression;Genes;Genetic;genetic variant;genome wide association study;Genomics;Genotype;Goals;Health;healthspan;healthy aging;high throughput screening;Human;Human Engineering;Human Genetics;human genomics;human pluripotent stem cell;human tissue;improved;Insulin;Insulin-Like Growth Factor I;interdisciplinary approach;Intervention;Laboratories;life span;Longevity;Longevity Pathway;MADH3 gene;Malignant Neoplasms;Methods;model organism;Molecular;multiple omics;Nematoda;Neurodegenerative Disorders;new therapeutic target;NFKBIA gene;novel;novel therapeutics;Pathway interactions;pharmacologic;Phenotype;Primates;protein expression;protein function;Proteins;rate of aging;Reporter;Research Personnel;resilience;Resistance;Risk;Risk Factors;Rodent;Role;screening;Severities;Signal Pathway;Signal Transduction;social;Stress;Testing;Therapeutic;therapeutic target;Translating;Untranslated RNA;Validation;Variant;Yeasts

PROJECT_TITLE: Identification and characterization of functional genetic variants associated with human longevity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE The human brain is supplied by 600 km of vessels where each neuron has its supplying microvessel. Aging impairs functionally and structurally the cerebromicrovasculature and thus induces consequential neuronal dysfunction and cognitive impairment. Endothelial senescence, as a damage response in aging, might contribute to impaired cerebral microvascular function and structure and by selective elimination of senescent cells offers new targets for prevention and treatment of age-related cognitive impairment.

PI_NAMEs: CSISZAR, ANNA  (contact);UNGVARI, ZOLTAN ISTVAN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abbreviations;Affect;age related;Age-associated memory impairment;Aging;aging brain;aging mechanism;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Cell Aging;cell type;Cells;Cellular biology;cellular imaging;Cellular Morphology;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Characteristics;Cognition;cognitive performance;contrast imaging;cost estimate;cytokine;Data;density;DNA Damage;Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;Ganciclovir;Gene Expression;genetic manipulation;Heterogeneity;Homeostasis;Human;human old age (65+);Hyperemia;Imaging Techniques;Impaired cognition;Impairment;improved;Intervention;Laser Speckle Imaging;Learning;liposomal delivery;Maintenance;Matrix Metalloproteinases;Mediating;Mediator;Memory;microvascular aging;Modality;Morphology;mouse model;network architecture;neuroinflammation;Neuronal Dysfunction;Neurons;neurovascular;neurovascular coupling;neurovascular unit;novel;Nutrient;old mice;older patient;Oxidative Stress;Oxygen;paracrine;Pathogenesis;pathological aging;Pathway interactions;Persons;Phenotype;Play;prevent;Prevention;pro-aging;Production;programs;Proteins;Proteomics;Publishing;Radiation therapy;red fluorescent protein;Regulation;Reporter;response;Rodent Model;Role;senescence;senescent cell;senolytics;Series;stressor;Structure;Testing;Tight Junctions;transcriptomics;two-photon;Vascular blood supply;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Endothelium;Vasodilator Agents;Work

PROJECT_TITLE: Age-related vascular cognitive impairment: role of endothelial senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences

PI_NAMEs: MAR, ADAM CHRISTOPHER (contact)

PROJECT_TERMS: 3-Dimensional;Affect;affiliative behavior;Agonistic Behavior;analysis pipeline;analytical tool;Animal Behavior;Animal Welfare;Animals;Behavior;Behavior assessment;Behavior monitoring;behavior test;Behavioral;Biological Assay;BRAIN initiative;Breeding;Collaborations;commune;Communication;Complex;Computer software;Computer Vision Systems;Computers;Core Facility;Custom;Darkness;Data;Data Analyses;Data Collection;data pipeline;Data Science Core;Data Set;data streams;Decision Making;deep learning;design;Detection;Development;Ensure;Environment;Ethology;experience;Experimental Designs;facility renovation;flexibility;Funding;Genetic;Home;Hour;Housing;Image;improved;Individual;information processing;Infrastructure;innovation;Investments;Laboratories;learning network;Light;Machine Learning;Measures;medical schools;member;Methods;Modality;Molecular;Monitor;Mus;neural;neural circuit;neuroregulation;Neurosciences;next generation;novel;optogenetics;Oxytocin;parallel processing;Parents;Partner in relationship;Postdoctoral Fellow;Posture;predictive modeling;Protocols documentation;Quantitative Evaluations;Research;Resources;Rodent;Scientist;social;Social Development;Social Environment;Social Hierarchy;Social Interaction;Spatial Behavior;Specific qualifier value;Standardization;success;System;Techniques;Testing;tool;touchscreen;Training;training project;Transgenic Mice;Validation;Vendor;Work

PROJECT_TITLE: Behavior Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Mutational signature analysis is an increasingly important technique in cancer discovery, based on extracting patterns from the changes in tumor DNA, to reveal important aspects of the underlying carcinogenic process. The goal of this proposal is to develop, test, and pilot a general, robust, and comprehensive approach for the statistical analysis of the mutation data typically used to learn mutational signatures. The result will be open source and freely available software tools that will enable more rapid discovery, and also provide a more realistic assessment of the accuracy of results.

PI_NAMEs: PARMIGIANI, GIOVANNI LUIGI (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Acceleration;Address;analytical tool;Assessment tool;Bayesian Modeling;Bioconductor;Biology;cancer cell;cancer type;carcinogenesis;carcinogenicity;Carcinogens;clinical application;clinical translation;Clinical Trials;Computer software;Data;Data Analyses;Data Analytics;Development;Disease;DNA;DNA Repair;Drug resistance;exome;experience;Frequencies;genome sequencing;Genomics;Goals;Grant;Growth;interest;Learning;Malignant Neoplasms;Maps;Methods;Modeling;Morphologic artifacts;Multiple Myeloma;Multivariate Analysis;Mutation;Mutation Analysis;novel;Oncogenic;open source;Pattern;pressure;Probability;Process;programs;Research Personnel;Resort;Role;Scientist;Software Tools;Somatic Mutation;Statistical Data Interpretation;Statistical Methods;Statistical Models;Study models;success;Techniques;Testing;Tissues;Tobacco smoking behavior;tool;tumor;tumor DNA;Ultraviolet Rays;Uncertainty;Visualization;whole genome;Work

PROJECT_TITLE: Statistical methods for cancer mutational signatures

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: LOUIE, KENWAY  (contact)

PROJECT_TERMS: Affect;Animal Behavior;Animals;Architecture;Area;Behavior;behavior prediction;Behavioral;Biophysics;Brain;BRAIN initiative;Code;Cognitive;cognitive process;Collaborations;Complex;Computer Analysis;computer framework;Computer Models;computing resources;Core Facility;Data;Data Collection;data modeling;Data Science;Data Science Core;Data Set;data standards;Decision Making;Dedications;Development;Disinhibition;diverse data;Electrodes;Electrophysiology (science);Ensure;experience;experimental study;flexibility;Foundations;Goals;Hippocampus;in vivo imaging;Individual;information processing;interest;Knock-out;Lead;Learning;Link;Mediating;medical schools;member;Metadata;Methods;Modeling;Molecular;Molecular Profiling;network models;neural;neural circuit;neurobehavioral;neuroregulation;Neurosciences;Oxytocin;Oxytocin Receptor;Postdoctoral Fellow;predictive modeling;Process;Property;Psychological reinforcement;repository;Research;Research Support;Role;Scientist;simulation;Social Behavior;Social Hierarchy;social learning;Social Network;Source Code;Standardization;Structure;Synapses;Techniques;Testing;theories;Training;Validation;Whole-Cell Recordings;Work

PROJECT_TITLE: Computational Modeling Core


PHR: PROJECT NARRATIVE - PROJECT 3 The goal of Project 3 is to validate rare sequence variants identified in centenarians by Projects 1 and 2, which are hypothesized to contribute to their healthy aging, in mice. This can be done rapidly by overexpression or depleting expression of the target gene in Ercc1-/D mice, which age six times faster than normal mice, using existing transgenic strains. Project 3 will also test drugs developed and validated by Project 4, which target the same pathways, in Ercc1-/D mice and aged wild-type mice for their ability to promote healthy aging.

PROJECT_TERMS: 5 year old;Acceleration;Adenosine;Affect;Age;age acceleration;age related;aged;Aging;aging mechanism;Animals;Attenuated;Biological Models;Candidate Disease Gene;Cell Aging;Centenarian;Chronic Disease;Code;Collaborations;college;Complex;CRISPR/Cas technology;Data;Deacetylase;Defect;Diphosphates;Disease;DNA Damage;DNA lesion;DNA Repair Endonuclease;DNA Resequencing;drug discovery;Drug Targeting;drug testing;efficacy testing;Epigenetic Process;ERCC1 gene;Evaluation;exome;extreme human longevity;follower of religion Jewish;FOXO3A gene;frailty;Frequencies;fucoidan;Funding;gene product;Gene Targeting;Genes;Genetic;genetic analysis;genetic approach;Genetic study;genetic variant;Genome Stability;genome-wide;Genotoxic Stress;Geropathology;Goals;Grant;hallmarks of aging;Health;healthspan;healthy aging;Heterozygote;Human;I-kappa B Proteins;IGF1R gene;improved;in vivo;inhibitor;innovation;Intervention;Life;life span;Link;Location;Longevity;macromolecule;MADH3 gene;Mammals;Measures;Medicine;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Target;mouse model;Mouse Strains;multiple chronic conditions;Mus;mutant;Mutate;Mutation;NF-kappa B;novel;novel therapeutic intervention;overexpression;oxidative damage;Oxidative Stress;p65;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenotype;Point Mutation;pre-clinical;Proteomics;Rapid screening;rare variant;Reactive Oxygen Species;Reporter;resilience;Resources;Risk;Role;senescence;senescent cell;Sleep Deprivation;stem cell function;Syndrome;Testing;TNFRSF5 gene;tool;transcriptomics;Transgenes;Transgenic Model;Transgenic Organisms;Translations;Untranslated RNA;Validation;Variant;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Validation and characterization of the identified variants associated with human longevity in mouse models


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Endometrial cancer is more common than all other gynecologic cancers combined, and the incidence and death rates have both increased over the past 25 years. The work proposed will lead to both an improved understanding of endometrial cancer biology and new approaches to prevent and treat this disease. Additionally, this SPORE will expand the numbers of researchers dedicated to studying endometrial cancer.

PI_NAMEs: BENBROOK, DORIS MANGIARACINA;LESLIE, KIMBERLY K.;MUTCH, DAVID G (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Affect;Aftercare;angiogenesis;anti-cancer research;Atypical Endometrial Hyperplasias;axl receptor tyrosine kinase;behavior test;biobank;Bioinformatics;Biological;Biological Process;biomarker identification;Biometry;Biopsy;Body Weight decreased;Cancer Biology;Cancer Model;Cancer Patient;Cancer Science;cancer therapy;career;Clinical;clinical practice;Clinical Trials;Collaborations;Combination Drug Therapy;Communities;Complement;Data;Data Analyses;Death Rate;Dedications;design;Development;Disease;drug development;Drug Kinetics;Early Diagnosis;early phase clinical trial;effective therapy;Endometrial Carcinoma;Endometrial Hyperplasia;Enrollment;Ensure;Equity;Fertility;fluorescence imaging;forging;Fostering;Funding;Future;Genes;Goals;Health Sciences;Heat shock proteins;Histology;Immunohistochemistry;Immunologics;improved;Incidence;Individual;inhibitor;innovation;Institution;interest;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Marriage;Measures;member;Mentors;Metabolic;metabolomics;Minority;Molecular;Molecular Chaperones;molecular marker;Mutation;New Mexico;novel;novel drug combination;novel marker;novel strategies;novel therapeutics;Obesity;Oklahoma;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Population Sciences;pre-clinical;Premenopause;preservation;prevent;Prevention;Prevention strategy;Primary Prevention;Progestins;programs;Proteins;recruit;Recurrence;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;response biomarker;Route;Scientist;Specialized Program of Research Excellence;Specimen;stable isotope;Standardization;Testing;Therapeutic;therapy outcome;TP53 gene;Translational Research;translational research program;translational study;treatment response;treatment strategy;Tumor Biology;Underrepresented Minority;Underrepresented Populations;United States;Universities;Uterus;virtual;Washington;Woman;Work

PROJECT_TITLE: Route 66 Endometrial Cancer SPORE


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE. This project seeks to define how the protein Muscleblind-like protein 1 (MBNL1) regulates cardiomyocyte differentiation and heart regeneration. Heart disease is the number one cause of death globally because the adult heart is incapable of any meaningful regeneration after injury due to a postnatal developmental switch during which cardiomyocytes transition from an immature, proliferative state to a mature, terminally differentiated state largely incapable of proliferation. MBNL1 has never been studied in this context, but understanding its role in controlling cardiomyocyte differentiation, cardiac regeneration, and the mechanisms by which it acts will allow us to determine if modulation of MBNL1 could be used therapeutically for the creation of novel regenerative medicine approaches to treating cardiovascular disease.

PI_NAMEs: BAILEY, LOGAN ROBERT JEFFERSON (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Address;Adult;Biological;Biological Assay;Biological Models;Biology;Calcium;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cardiovascular Diseases;Cause of Death;cell behavior;Cell Cycle;Cell Differentiation process;cell growth;Cell Proliferation;cell type;Cells;critical developmental period;Data;Development;Disease;Dose;Embryo;Embryonic Heart;Event;Experimental Genetics;fetal;gain of function;Genes;genetic approach;genetic information;Genetic Models;Genetic Transcription;Glean;Growth;Heart;Heart Diseases;Heart failure;High-Throughput RNA Sequencing;Hypertrophy;In Vitro;in vivo;in vivo regeneration;Injury;insight;Ions;Knock-out;Knowledge;Link;loss of function;Maintenance;mature animal;Messenger RNA;Metabolic;Modeling;Molecular Biology;Molecular Target;Mus;Muscle;Myocardial Infarction;Natural regeneration;Neonatal;new therapeutic target;novel;Outcome;Pathway interactions;Play;pluripotency;Post-Transcriptional Regulation;postnatal;postnatal development;posttranscriptional;prenatal;Process;programs;Proliferating;Protein Isoforms;Proteins;rational design;regeneration potential;Regenerative capacity;Regenerative Medicine;Regulation;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;single nucleus RNA-sequencing;stem cells;Tamoxifen;Testing;Therapeutic Uses;Time;Transcript;Transcriptional Regulation;transcriptome;transcriptomics

PROJECT_TITLE: Investigating the Role of MBNL1 in Maintaining Cardiomyocyte Terminal Differentiation.


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Uterine Cancer;Women's Health Research

PI_NAMEs: MUTCH, DAVID G (contact)

PROJECT_TERMS: Advocacy;Advocate;Amendment;Bioinformatics;Biometry;Biostatistics Core;Body System;Budgets;career;Caring;Clinical Trials;Collaborations;Committee Members;Communication;Conduct Clinical Trials;Contracts;Decision Making;Development;Documentation;Electronics;Endometrial;Endometrial Carcinoma;Enrollment;Ensure;Equity;Ethics;Fostering;Goals;Grant;Human Resources;innovation;Institution;Institutional Review Boards;Instruction;Malignant Neoplasms;meetings;metabolomics;mindfulness;Mission;National Cancer Institute;New Mexico;Newsletter;next generation;Oklahoma;operation;Participant;Pathology;Patients;payment;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Route;Services;Site;Specialized Program of Research Excellence;success;Sum;Time;Underrepresented Minority;Universities;Washington;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Natural Products;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE – PROJECT 4 The overall goal of this U19 is to use genetic variation in human populations linked to extreme phenotypes of healthy aging, centenarians and super-centenarians, to identify rare variants in genes and pathways important for human aging for guiding drug development. Project 4 will focus on developing therapeutics targeting these identified rare variants and pathways, leading to new drugs for extending healthy lifespan.

PI_NAMEs: VIJG, JAN  (contact)

PROJECT_TERMS: Adenosine;age acceleration;Aging;aging mechanism;Apoptosis;appropriate dose;Bar Codes;Binding;Biodistribution;Biological Assay;CDKN2A gene;Cell Culture Techniques;Cell Line;Cell Lineage;Centenarian;Clinical;Clinical Research;Code;Collaborations;Complex;Data;Development;Diphosphates;DNA;DNA Repair;drug development;drug discovery;Drug Kinetics;FDA approved;Flavanol;Fluorescence Resonance Energy Transfer;FOXO3A gene;fucoidan;Funding;Generations;Genes;Genetic Code;genetic variant;Genetic Variation;Goals;healthspan;healthy aging;helicase;high-throughput drug screening;homologous recombination;Human;I-kappa B Proteins;IGF1R gene;improved;in silico;in vivo;induced pluripotent stem cell;Inflammation;inhibitor;Investigational Drugs;Lead;Libraries;Link;Longevity;Longevity Pathway;Luciferases;luminescence;MADH3 gene;model organism;mouse model;Mus;Natural Products;new therapeutic target;NF-kappa B;Nonhomologous DNA End Joining;normal aging;novel;novel therapeutics;old mice;Oligosaccharides;p65;Pathologic;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Population;pre-clinical;promoter;Protac;rare variant;Regimen;Reporter;Research;screening;Seaweed;senescence;senescent cell;Senotherapeutic;Signal Pathway;Signal Transduction;small molecule;stem cells;Structure-Activity Relationship;Sulfate;Testing;therapeutic evaluation;therapeutic target;Time;TNFRSF5 gene;Toxicology;ubiquitin-protein ligase;Untranslated RNA;Variant

PROJECT_TITLE: Development of novel therapeutics targeting the identified pathways associated with human longevity


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed work will help understand a wide range of biological processes involving the interactions between biomolecular condensates and other cellular structures, particularly cell membranes. Our work will also elucidate the effects of protein mutations and putative drugs on the material properties of biomolecular condensates in live neurons. Insights from the data can be used to unravel molecular mechanisms, as well as facilitate therapeutic advances in the treatment of neurodegenerative diseases.

PI_NAMEs: SHI, ZHENG  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Animals;aspirate;Autophagocytosis;Biological;Biological Process;Cell Line;Cell membrane;Cell surface;Cells;Cellular Structures;Complex;Cytoplasmic Granules;Data;Exocytosis;experimental study;Growth;insight;Liquid substance;Mechanics;Mediating;Membrane;Microtubules;Molecular;Morphologic artifacts;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;Organelles;patch clamp;Pathologic;Pharmaceutical Preparations;Phase;Phase Transition;Physical condensation;Process;Property;Proteins;Role;Signal Transduction;Solid;Source;Surface Tension;Synapses;Synapsins;Synaptic Vesicles;Techniques;Testing;Therapeutic;Tight Junctions;tool;trafficking;transmission process;Vesicle;vesicular release;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Understanding the viscoelasticity, surface tension, and membrane interactions of biomolecular condensates in live cells


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Uterine Cancer;Women's Health Research

PHR: PROJECT NARRATIVE The rate of endometrial cancer deaths is increasing and current treatments cause serious side effects. This project will study a new drug, called SHetA2, that has shown no significant toxicities to date and is targeted at specific molecular defects that occur in endometrial cancers. The outcome of this research has the potential to optimize SHetA2-based treatments for endometrial cancer patients and identify those patients who will most likely benefit from this therapy.

PI_NAMEs: BENBROOK, DORIS MANGIARACINA (contact)

PROJECT_TERMS: Address;advanced disease;Advanced Malignant Neoplasm;Aneuploid Cells;Animal Model;Apoptosis;Autophagocytosis;Binding;biomarker identification;cancer cell;Cancer cell line;Cancer Patient;cancer survival;cancer therapy;carcinogenesis;Carcinoma;Categories;CDK4 gene;Cell Cycle Arrest;Cell Cycle Progression;Cell Death;Cell Line;Cell Nucleus;Cell Survival;Cells;Centrosome;Cessation of life;Chromosomes;Classification;Client;Clinical Trials;Complement;Complex;Cyclin D1;Cyclin-Dependent Kinases;Data;Defect;Development;Disease;DNA Sequence Alteration;Dose;Drug Combinations;Drug Kinetics;drug testing;Endometrial;Endometrial Carcinoma;Endoplasmic Reticulum;endoplasmic reticulum stress;Epigenetic Process;Epithelial Cells;first-in-human;Future;G1 Arrest;Gene Mutation;Genes;Genetic;Genetic Induction;Grant;Growth;Growth and Development function;GRP78 gene;Heat shock proteins;Homeostasis;improved;in vivo;Incidence;Induction of Apoptosis;inhibitor;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;Mediating;Metabolism;Mitochondria;Molecular;Molecular Chaperones;Molecular Profiling;mortalin;mortality;Mutation;novel therapeutics;Oncoproteins;Organelles;Organoids;Outcome;Outcomes Research;overexpression;Paclitaxel;patient prognosis;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;Phase Ib/II Clinical Trial;phase III trial;Phosphorylation;Phosphotransferases;preclinical study;predictive marker;Preparation;prevent;Progression-Free Survivals;Proliferating;protein complex;Proteins;PTEN gene;Randomized;Recurrence;Recurrent disease;Refractory;Regulation;response;Route;Schedule;Serous;SHetA2;side effect;Specimen;standard of care;Stress;synergism;Systems Biology;Testing;The Cancer Genome Atlas;Therapeutic;Toxic effect;TP53 gene;Treatment Efficacy;tumor;Tumor Burden;tumor growth;Uterus;Woman;Xenograft procedure

PROJECT_TITLE: Project 1: Targeting HSPA Proteins in Advanced and Recurrent Endometrial Cancer Therapy


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: NARRATIVE The role of gastrin as a hormone controlling acid secretion is well understood, however, the impact of gastrin on the regulation of epithelial growth has been less clear. In addition, our understanding of stem and progenitor cells in the stomach is quite limited. The proposed studies will broaden our understanding of gastrin’s role in modulating gastric progenitors; and advance the treatment of peptic ulcer disease and gastric tumorigenesis.

PI_NAMEs: WANG, TIMOTHY CRAGIN (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;Acetic Acids;Acids;Agonist;Antral;Bacterial Artificial Chromosomes;Behavior;bone;carcinogenicity;Carcinogens;CCKBR gene;Cell Count;Cell division;Cell Lineage;Cell Proliferation;Cells;Cholecystokinin B Receptor;Data;Diphtheria Toxin;Disease;Endocrine;Enterochromaffin Cells;Enterochromaffin-like Cells;Epithelial Cells;Epithelium;Exhibits;G Cells;G-Protein-Coupled Receptors;Gastric Parietal Cells;gastric tumorigenesis;Gastrins;Gene Expression;Gland;Growth;healing;Helicobacter;Helicobacter Infections;Hormonal;Hormone secretion;Hormones;Human;In Vitro;in vivo;Inflammation;Injury;Long-Term Effects;Longevity;Mediating;Methylnitrosourea;Natural regeneration;Parietal;Pathway interactions;Peptic Ulcer;peptide hormone;Population;Prevention;Process;Production;progenitor;Proliferating;Publishing;Pyloric antrum;receptor;regeneration following injury;Regenerative response;Regulation;response;response to injury;Role;self renewing cell;Signal Transduction;single-cell RNA sequencing;stem;stem cell division;stem cell proliferation;stem cells;stemness;Stomach;Stomach Neoplasms;Technology;Time;Transgenic Mice;Ulcer

PROJECT_TITLE: Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(05)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative Adaptation is a fundamental attribute of living systems, allowing organisms to react to their environments on scales ranging from the physiological responses to environmental signals to long-term evolutionary adaptations. The work proposed here aims to provide a quantitative description of the adaptive dynamics of cells by exploring how cells mount responses through rapid changes in molecular conformation, alterations in the proteome through regulated gene expression and evolutionary rewiring of the genome in contexts such as the rise of antibiotic resistance. This work will provide a far-reaching but detailed view of how cells adapt by integrating precise measurements with biophysical theory.

PI_NAMEs: PHILLIPS, ROB  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Adopted;Amaze;Antibiotic Resistance;Antibiotics;Award;Binding;biological systems;Biology;Biophysics;Carbon;Case Study;Cells;Chromosome Segregation;Cytoskeleton;Environment;Escherichia coli;Evolution;Gene Expression;Generations;Genes;Genome;genome sciences;Goals;gut bacteria;gut microbiota;Health;Human;improved;Individual;Laboratories;Light;Measurement;Metabolic;Molecular Biology;Molecular Conformation;Motor;Operon;Organism;Organization administrative structures;pathogenic bacteria;Physiological;Population;Proteins;Proteome;Reaction;Research;response;Signal Transduction;Source;Stress;success;System;theories;Time;transcription factor;Transcriptional Regulation;whole genome;Work

PROJECT_TITLE: The Principles of Regulatory, Conformational and Evolutionary Adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PHR: Project Narrative An effective treatment for metastatic osteosarcoma is a critical unmet medical need. Our preclinical data demonstrate that a neutralizing antibody against the canonical Wnt signaling antagonist, DKK-1, slows primary tumor growth, induces nuclear translocation of β-catenin, upregulates markers of differentiation, and abolishes metastasis in a mouse model of osteosarcoma based on patient-derived xenografts. We propose testing a small molecule inhibitor of DKK-1 in a similar model to determine effects on both canonical and noncanonical Wnt signaling, on the growth and differentiation of osteosarcoma patient-derived xenografts, and on osteosarcoma metastasis, as well as validating DKK-1 serum levels as a biomarker of disease burden and response to therapy in patients newly diagnosed with osteosarcoma.

PI_NAMEs: LOEB, DAVID M. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Adolescent and Young Adult;Affect;antagonist;beta catenin;Biological Markers;Biology;Biopsy Specimen;Blood;bone;burden of illness;Cause of Death;Cell Differentiation process;Cells;Chemoresistance;chemotherapy;Clinical Trials;clinically relevant;Collaborations;Complex;Data;Diagnosis;Differentiation and Growth;Differentiation Antigens;Disease;effective therapy;Equilibrium;established cell line;Excision;Foundations;Gene Expression;Genetic;Genetically Engineered Mouse;glycogen synthase kinase 3 beta;Harvest;Human;immunodeficiency;improved;inhibitor;Investigation;Laboratories;Laboratory Finding;Ligands;Localized Disease;Malignant - descriptor;Malignant Childhood Neoplasm;MAP Kinase Gene;MAPK8 gene;Measures;Medical;Metastatic Osteosarcoma;Modeling;Monoclonal Antibodies;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Newly Diagnosed;novel;novel therapeutic intervention;Nuclear Translocation;Operative Surgical Procedures;osteoblast differentiation;Osteosarcoma;Pathway interactions;patient derived xenograft model;Patients;peripheral blood;pharmacologic;Phosphotransferases;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;prevent;primary bone cancer;Primary Neoplasm;Process;Prognosis;Prognostic Marker;Proliferating;receptor;Recurrence;Relapse;relapse risk;Reporting;Resected;responders and non-responders;Role;Serum;Signal Pathway;Signal Transduction;small molecule inhibitor;Survival Rate;targeted treatment;Testing;treatment response;tumor;tumor growth;WNT Signaling Pathway;Xenograft Model

PROJECT_TITLE: Targeting DKK-1 To Prevent Osteosarcoma Metastasis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Studying coordinated cell processes in the 3D tissue context requires precise manipulation of cell behavior in time and space, however this is difficult to achieve in 3D culture using current biomaterials. To address this, our approach leverages innovative 3D biomaterial scaffolds that respond to focused ultrasound, allowing precise genetic manipulation of cellular behavior at specific times and locations. This research program will generate new insights into cellular processes and communication in the 3D context, including chemotaxis, with applications to tissue maturation, regeneration and wound repair.

PI_NAMEs: IBSEN, CAROLYN SCHUTT (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Affect;Biocompatible Materials;Biological;Biological Process;bioscaffold;cell behavior;Cell Communication;Cell Culture Techniques;cell motility;Cell Physiology;cell type;Cells;Cellular Structures;Chemotaxis;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;Complex;Disease;disease model;DNA delivery;Endothelial Cells;Endothelium;Focused Ultrasound;Gene Expression;Genes;genetic manipulation;Growth Factor;Individual;innovation;insight;intercellular communication;Knock-out;Libraries;Location;Mediating;Methods;migration;Natural regeneration;novel therapeutic intervention;Nucleic Acids;overexpression;particle;Pattern;Process;programs;protein expression;Protein Secretion;Proteins;regenerative therapy;Regulation;Research;Research Personnel;Role;scaffold;Societies;spatiotemporal;System;Testing;three dimensional cell culture;Time;tissue repair;Tissues;Transfection;ultrasound;Vascularization;Vision;Work;wound healing

PROJECT_TITLE: Genetically Manipulating Protein Expression to Probe 3D Cell Behavior using Ultrasound-Responsive Biomaterials


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine;Uterine Cancer;Women's Health Research

PHR: PROJECT NARRATIVE These studies seek to enhance standard-of-care treatment with chemotherapy and anti-angiogenic agent through inhibition of AXL in aggressive forms of uterine cancer.

PROJECT_TERMS: active method;Address;Affinity;angiogenesis;Angiogenesis Inhibitors;Apoptosis;axl receptor tyrosine kinase;bevacizumab;Binding;Biological Markers;Biopsy;Blood;blood glucose regulation;Blood Vessels;cancer cell;Cancer Histology;Cancer Patient;cancer type;Cell Survival;Cessation of life;Chemoresistance;chemotherapy;Chimeric Proteins;clinical care;Clinical Research;Clinical Trials;Data;density;Diagnosis;Disease;Dose;Drug Combinations;Drug Kinetics;Endometrial Carcinoma;Endometrial Neoplasms;Endometrioid Tumor;Equity;experimental study;Foundations;Future;Genes;Glycolysis;Growth;Histology;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;insight;Invaded;Ligands;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Metabolic;Metabolism;metabolomics;Monoclonal Antibody Therapy;mouse model;Names;Neoplasm Metastasis;neoplastic cell;new combination therapies;objective response rate;Oklahoma;open label;Paclitaxel;participant enrollment;Pathology;Pathway interactions;patient derived xenograft model;Patients;personalized medicine;Pharmacodynamics;Phase;Phase 1/1b Clinical Trial;Phase Ib Trial;phase II trial;Phenotype;PI3K/AKT;Platinum;Positioning Attribute;pre-clinical;primary outcome;Prognosis;Proliferating;protein expression;Publishing;recruit;Recurrence;Relapse;Resistance;response;Route;Safety;Sampling;secondary outcome;Serous;Serum;stable isotope;standard of care;Sterically Stabilized Liposome;targeted treatment;Testing;Tissues;Translating;treatment response;tumor;Tumor Burden;Universities;Uterine Cancer;Uterus;Vascular Endothelial Growth Factors;Washington;Woman;Work

PROJECT_TITLE: Project 2: Inhibiting AXL to Improve Treatment Response in Endometrial Cancer