ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: The VA has considered promoting increased use of lithium (LI) and clozapine (CLOZ) to prevent suicidal behavior. This study will analyze VA databases to greatly advance understanding of LI and CLOZ safety, and conduct a nationwide survey of VA MH prescribers about barriers and facilitators to LI and CLOZ use. VA databases contain far more LI users than previously studied, allowing crucial issues to be evaluated. These include identifying which patient groups would be the safest to target for increased use, and whether existing treatments and dosing strategies should be more widely used to prevent serious side effects. Findings will be summarized for Program Partners and providers, including in a user-friendly Guide and Patient-Provider Communication Tool prepared with the assistance of an Advisory Board of Veterans, VA leadership, providers, and subject experts. The survey will identify factors that might interfere or assist efforts to increase LI and CLOZ use. This state-of-the-art study will greatly enhance any future VA efforts to expand LI and CLOZ use.

PI_NAMEs: SMITH, ERIC G. (contact)

PROJECT_TERMS: Address;Age;anti-depressive agents;Area;Attitude;Behavior Therapy;behavioral health;Benefits and Risks;Caring;Characteristics;Clinical;clinical care;Clozapine;cohort;Communication;Communication Tools;comparison control;Control Groups;dashboard;Data;Databases;Development;Diagnosis;Dose;Electronic Mail;Ensure;evidence base;Formulation;Frequencies;Future;Goals;Health;implementation trial;improved;Incidence;informant;interest;Kidney;Knowledge;Leadership;Lithium;male;Medical;Mental Health;Mental Health Services;Metabolic;Metformin;Methodology;Monitor;mortality;Patient Care;patient subsets;patient-clinician communication;Patients;Pharmaceutical Preparations;pharmacy benefit;pilot test;policy implication;policy recommendation;Population;Predictive Analytics;predictive modeling;preference;prevent;Prevention strategy;preventive intervention;programs;Provider;provider behavior;randomized trial;Reporting;response;Risk;Risk Estimate;Risk Factors;risk minimization;risk mitigation;Safety;Serious Adverse Event;sex;side effect;Stratification;Structural Models;Subgroup;substance use;success;suicidal behavior;Suicide prevention;Surveys;Survival Analysis;Time;tool;treatment strategy;user-friendly;Veterans;Weight;willingness;ziprasidone

PROJECT_TITLE: Identifying Best Practices for Medication-Based Suicide Prevention Strategies to Minimize the Risk of Medically-Serious Adverse Events


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Transitioning Veterans (those who have recently separated from the military) are a high-risk group for suicide. Veterans are most likely to disclose suicidal thoughts to their close supports (family, friends, and peers). Most Veterans and their close supports are not aware of, nor have received, structured training in how to help someone at risk of suicide, despite strong interest in receiving such training. In this research project, we will use advertisements on social media to recruit transitioning Veterans and their close supports for a pilot randomized controlled trial to assess the feasibility and acceptability of a brief online training in suicide prevention called PsychArmor S.A.V.E., a gatekeeper training tailored to Veterans and their close supports. This highly scalable project has the potential to reduce suicide among Veterans by using a novel outreach strategy to increase help-seeking behavior in a high-risk population of Veterans.

PI_NAMEs: TEO, ALAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Advertisements;Agreement;analytical method;Area;arm;Attitude;Behavior;Behavioral;Caring;Characteristics;Clinical;clinical care;Clinical Practice Guideline;comparison group;Consensus;Data;Data Analyses;Data Analytics;Data Collection;Department of Defense;design;Diffuse;Educational Intervention;Educational process of instructing;effectiveness testing;Eligibility Determination;Enrollment;Evaluation;Family;Family member;family support;Feasibility Studies;Feedback;Feeling suicidal;follow-up;Friends;Future;Gatekeeping;Goals;help-seeking behavior;high risk;high risk population;improved;Individual;innovation;interest;Intervention;Intervention Studies;Interview;Knowledge;Link;Measurement;Measures;Mental Health;Methodology;Methods;Military Personnel;military veteran;novel;novel strategies;online intervention;Outcome;Outcome Assessment;outreach;Participant;Patient Recruitments;peer;Persons;Pilot Projects;Positioning Attribute;prevent;Process;Public Health;Qualitative Methods;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;reducing suicide;Research;Research Design;Research Project Grants;Risk;Self Efficacy;skills;social media;social networking website;social norm;social stigma;Structure;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Surveys;systematic review;Technical Expertise;Training;Training Programs;Veterans;Veterans Health Administration;web site;Work

PROJECT_TITLE: Increasing Help-Seeking Behavior Among Transitioning Veterans At Risk For Suicide With Online Gatekeeper Training: A Pilot Study Of PsychArmor S.A.V.E.

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: The rate of suicide among US military Veterans is approximately 50% higher than among non-Veterans. Suicide is a complex phenomenon that is highly associated with social determinants of health (SDH) including housing instability, justice involvement, and unemployment. Using existing Department of Veterans Affairs (VA) administrative data, and environmental scan of VA support programs, and qualitative interviews with VA support program staff and Veterans, this study will determine whether and how services to address SDH mitigate Veterans’ risk of suicide. Results will lay the groundwork to develop implementation trials to bolster VA and community social support services as non-medical components of suicide prevention for Veterans.

PI_NAMEs: MONTGOMERY, ANN ELIZABETH (contact);TRUE, JENNIFER GALA

PROJECT_TERMS: acceptability and feasibility;Address;Age;Area;Biological Factors;Cessation of life;Clinical;Communities;comorbidity;Complex;Data;Depression screen;design;Detection;Diagnosis;Disparity;Economics;Employment;experience;Experimental Designs;Goals;Health;health care service utilization;Health Services Administration;Healthcare Systems;Homelessness;housing instability;implementation trial;improved;informant;Infrastructure;innovation;Integrated Health Care Systems;Intervention;Interview;Justice;Legal;lens;Literature;Maps;Medical;Medical center;Medical Records;Mental Depression;Mental Health;Methodology;Methods;military veteran;Natural experiment;operation;Outpatients;Pain Disorder;Patients;Perception;Persons;Population;Predictive Analytics;prevent;Prevention;prevention practice;Prevention strategy;programs;Provider;Public Health;Questionnaires;Recording of previous events;Research;Scanning;Self-Injurious Behavior;service uptake;Services;social factors;social health determinants;Social isolation;Social support;Social Work;Structure;suicidal;suicidal morbidity;suicidal risk;Suicide;suicide mortality;Suicide prevention;suicide rate;System;Telephone Interviews;Testing;Thinking;tool;Training;Unemployment;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Violence;Visit;Work

PROJECT_TITLE: Can services to address Veterans social determinants of health reduce their suicide risk?


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Serious mental illnesses require years of monitoring and adjustments in treatment. Stress, substance abuse or reduced medication adherence cause rapid worsening of symptoms, with consequences that include job loss, homelessness, suicide, incarceration, and hospitalization. Treatment visits are infrequent. Illness exacerbations usually occur with no clinician awareness, leaving little opportunity to make treatment adjustments. Tools are needed that quickly detect illness worsening. At least 60% of Veterans with serious mental illness use a smart phone. These phones generate data that characterize sociability, activity and sleep. Changes in these are warning signs for relapse. Members of this project developed an app that monitors and transmits these mobile data. This project studies passive mobile sensing that allows Veterans to self-track their activities, sociability and sleep; and studies whether this can be used to track symptoms. The project intends to produce a mobile platform that monitors the clinical status of patients, identifies risk for relapse, and allows early intervention.

PI_NAMEs: YOUNG, ALEXANDER S. (contact)

PROJECT_TERMS: acceptability and feasibility;Adherence;Age;analytical method;Area;Awareness;Behavior;behavior change;Behavior monitoring;behavior prediction;Businesses;Categories;Cellular Phone;Clinical;Communication;Data;Data Analyses;data exchange;data privacy;Data Reporting;Data Security;Development;Diagnosis;Disabling;Early Intervention;Educational process of instructing;effectiveness study;effectiveness/implementation study;Feasibility Studies;Feedback;Focus Groups;Goals;Habits;handheld mobile device;Health Status;Healthcare;high dimensionality;Homelessness;Hospitalization;Imprisonment;improved;Individual;Informatics;innovation;Institutional Review Boards;interest;Intervention;Interview;Job loss;Light;Location;Measures;medication compliance;member;Mental Health;Mental Health Services;Methodology;Methods;military veteran;mobile application;mobile computing;mobile phone based intervention;mobile sensing;mobile sensor;Modeling;Monitor;Movement;novel strategies;Ownership;Patients;perceived stress;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Population;Predictive Value;Privacy;psychiatric symptom;psychotic-like experiences;rapid detection;Relapse;relapse risk;Reporting;Research;Research Methodology;Research Personnel;Risk;Risk Behaviors;Safety;Security;Self Management;sensor;service utilization;severe mental illness;Signs and Symptoms;Sleep;smartphone application;Social Interaction;sound;Stress;Substance abuse problem;Suicide;Symptoms;Telephone;Testing;therapy development;Time;tool;transmission process;treatment and outcome;treatment as usual;Uncertainty;usability;user centered design;Veterans;Visit;Work

PROJECT_TITLE: Passive Mobile Self-Tracking of Mental Health by Veterans with Serious Mental Illness


ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Many Veterans experience impairing symptoms of anxiety and seek treatment in the primary care setting, yet behavioral (non-medication) anxiety treatment options in primary care are quite limited. Primary Care-Mental Health Integration (PCMHI), in which mental health clinicians embedded in primary care provide behavioral treatment, can help bridge this treatment gap, but brief anxiety interventions that are compatible with PCMHI practice are needed. This proposal evaluates a brief anxiety intervention that is evidence-based, transdiagnostic (applicable to a wide range of anxiety symptoms), feasible for delivery in PCMHI (brief sessions), and Veteran-centered (tailored to Veterans and personalized to individual patients). This research addresses a major gap in VHA treatment options for anxiety and will facilitate high quality Veteran healthcare that improves clinical outcomes and patient experience. The intervention’s innovative modular design, in which Veterans collaboratively select which coping skills to learn, improves treatment engagement and acceptability.

PI_NAMEs: SHEPARDSON, ROBYN LEANNE (contact)

PROJECT_TERMS: Address;Adult;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;anxiety treatment;Area;associated symptom;Behavior Therapy;Behavioral;behavioral health;brief intervention;care providers;care systems;Caring;Client satisfaction;Clinical;clinically significant;Cognitive;Cognitive Therapy;comorbidity;Consultations;coping;Coping Skills;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Early treatment;Educational Intervention;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;Ensure;evidence base;Evidence based intervention;experience;Face;flexibility;follow-up;Funding;future implementation;Health Personnel;Health Services Accessibility;Health Services Research;Healthcare;High Prevalence;Hybrids;Impairment;implementation efforts;implementation science;improved;individual patient;innovation;Intervention;intervention delivery;Leadership;Learning;Logistic Regressions;Maintenance;Manuals;Measures;medical specialties;Mental Health;Mental Health Services;Methodology;Methods;Modeling;multilevel analysis;Nonpharmacologic Therapy;Outcome;Participant;Patient Preferences;Patients;Pharmacotherapy;Philosophy;preference;prevent;Primary Care;primary care patient;primary care setting;primary outcome;Procedures;process evaluation;Protocols documentation;Provider;psychoeducation;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;relapse prevention;Relaxation;Research;research and development;Research Methodology;routine care;satisfaction;secondary outcome;Severities;Site;skills;skills training;Sleeplessness;Stress;suicidal;Suicide prevention;Supervision;Symptoms;Techniques;therapy design;treatment as usual;Treatment Protocols;treatment response;trial comparing;United States Health Resources Administration;Use Effectiveness;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Improving Anxiety Treatment Engagement and Effectiveness in Primary Care-Mental Health Integration: Multi-site Hybrid I RCT of a Brief Veteran-Centered Anxiety Intervention


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT SUMMARY/ABSTRACT: OVERALL COBRE on Implementation Science & Equity Gaps between evidence-based and clinical practice are far greater in the delivery of care to vulnerable subgroups, leading to health and treatment disparities. It is critical to accelerate the adoption of evidence- based practices into healthcare, and Implementation Science is the emerging field that aims to do so. This COBRE will provide mentoring and support to build the Implementation Science and Equity research workforce across our institution, with the goal of ensuring that all Americans receive care that is guided by current professional knowledge and is designed to achieve the best outcomes possible.

PI_NAMEs: BEFORT, CHRISTIE  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Advisory Committees;Alzheimer's Disease;American;Area;Attention;Award;care delivery;care systems;Caregivers;Caring;Centers of Research Excellence;Child;Clinic;clinical care;clinical practice;Clinical Research;Communities;Community Healthcare;cost;design;Development;Diagnosis;Dietetics;Dimensions;disability;Discipline of Nursing;Disparity;disparity gap;Disparity population;early-career faculty;Economics;Education;end of life;Ensure;Equitable healthcare;Equity;Ethical Issues;Ethnic Origin;evidence base;Evidence based intervention;Evidence based practice;experience;Family;Funding;Future;Gender;Geography;Goals;Growth;Health;Health behavior;health care delivery;health care quality;health care service organization;health disparity;health inequalities;Health system;Healthcare;Healthcare Systems;human subject;implementation research;implementation science;improved;Income;Inequity;Infant;Infrastructure;innovation;Institution;institutional capacity;Interdisciplinary Study;International;Journals;Kansas;Knowledge;Laboratory Study;Latino;Lead;Leadership;literacy;Medical center;Medical Research;medical specialties;Medicine;Mentors;Methodology;Minority;minority investigator;multidisciplinary;National Cancer Institute;National Heart, Lung, and Blood Institute;NIH Program Announcements;novel;novel therapeutics;nutrition;organizational structure;Outcome;Patients;Phase;Policies;Population;Positioning Attribute;Pre-Eclampsia;Pregnancy;Prevention;Primary Care;Procedures;Process;programs;psychologic;Psychology;Quality of Care;racial disparity;Recommendation;Records;Research;Research Project Grants;Rural;Rural Health;rurality;Schools;Services;Sex Orientation;social;Societies;Study Section;Subgroup;symposium;System;Talents;Testing;Time;Tobacco Use Cessation;Training;Translating;Translation Process;treatment disparity;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;uptake;Urban Health;Woman

PROJECT_TITLE: Implementation Science and Equity


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Acceleration;Accounting;Administrative Efficiency;Adopted;Advisory Committees;American;Behavioral;career;career development;Centers of Research Excellence;Clinical;clinical practice;Collaborations;Complex;Development;Development Plans;Disease;Doctor of Philosophy;Ensure;Environment;Equity;ethnic minority;evidence base;experience;Faculty;Funding;Goals;Health;health equity;Health Status;Healthcare;implementation evaluation;implementation research;implementation science;implementation tool;Infrastructure;Institution;interest;International;Lead;Leadership;member;Mentors;Methods;Mission;multidisciplinary;Nature;novel;Office of Administrative Management;Outcome;Pilot Projects;practice-based research network;Prevention;Primary Care;programs;Provider;racial minority;Research;research and development;Research Personnel;Research Support;Resource Sharing;Resources;Rural;Rural Minority;safety net;Services;Site;Structure;success;Systems Development;Techniques;Time;Training;Translational Research;treatment and outcome;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Implementation Science and Equity: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

PI_NAMEs: CALHOUN, ELIZABETH ANN (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Awareness;Benchmarking;Caregivers;Centers of Research Excellence;Collaborations;Communication;Communities;community based research;community collaboration;community engagement;Community Healthcare;community organizations;Community Outreach;community partners;Core Facility;COVID-19 pandemic effects;cultural competence;Data;design;Development;disparity reduction;Education;Effectiveness;Equity;Evaluation;evidence base;Evidence based intervention;experience;Family;Family member;Funding;Goals;Health;health disparity;health equity;Health Professional;Health system;Healthcare;Healthcare Systems;implementation intervention;implementation research;implementation science;implementation strategy;improved;Incentives;Individual;Inequity;Infrastructure;Institution;interest;Intervention;investigator training;Investments;Kansas;Link;Lived experience;Methods;Neighborhoods;Outcome;Patients;Pilot Projects;Policies;Policy Maker;Population;population health;Process;Provider;provider behavior;Race;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Rural;service engagement;Services;social health determinants;Societies;System;therapy design;Time;Training;Trust;underserved community;Vision;Work

PROJECT_TITLE: Implementation Science and Equity: Community Engagement & Outreach (CEO) Core


PI_NAMEs: ELLERBECK, EDWARD F. (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Behavior;behavior change;Biometry;care outcomes;Centers of Research Excellence;Clinical;Clinical Data;Clinical Informatics;clinical research site;Clinical Sciences;Collaborations;collaborative environment;Collection;Communities;community collaboration;community engagement;Community Healthcare;Community Outreach;Complex;Data;design;disparity gap;Ensure;Environment;Epidemiology;Equity;Evidence based intervention;Evidence based practice;experience;Federally Qualified Health Center;Fostering;frontier;health disparity;health equity;Health equity research;health inequalities;Health Personnel;Healthcare;healthcare community;human subject;implementation research;implementation science;implementation strategy;implementation study;improved;innovation;Institution;Kansas;Learning;Medical center;Medical Informatics;member;Methods;Minority;Modeling;NCI-Designated Cancer Center;Outcome;Outcome Measure;patient engagement;Performance;Population Heterogeneity;pragmatic implementation;Process;Process Measure;programs;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Resources;Rural;rural health clinic;rural underserved;satisfaction;Scanning;Science;service delivery;Services;Site;skills;Specific qualifier value;success;Talents;theories;tool;Training;Translational Research;treatment disparity;underserved community;Universities;uptake;urban underserved;Variant;Vision;Work

PROJECT_TITLE: Implementation Science and Equity: Pragmatic Implementation Science Methods (PrISM) Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project seeks to fulfil an unmet need for CCR2-specific imaging test. Currently there is no clinical biomarker that can be used to select patients for CCR2-targeted therapy and to monitor response to such therapy. Considering the toxicity and the rate of response to CCR2-targeted therapy, it is crucial to be able to identify patients who may not response to this therapy in order to avoid the morbidity and expense associated with ineffective therapy.

PI_NAMEs: DEHDASHTI, FARROKH  (contact);LIM, KIAN H;LIU, YONGJIAN

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Aftercare;Animal Model;antagonist;anti-CTLA4 antibodies;anti-PD-1;anti-PD1 therapy;beta-Chemokines;Biology;Biopsy;Blood;cancer imaging;cancer immunotherapy;cancer type;Cells;chemokine;chemokine receptor;chemotherapy;clinical biomarkers;Clinical Data;Clinical Treatment;Clinical Trials;Conduct Clinical Trials;Data;Data Analyses;Detection;detection sensitivity;Development;diagnostic tool;Disease;disease model;Disease Progression;early phase clinical trial;effective therapy;first-in-human;Future;Genetic;Grant;Human;human tissue;Image;image guided;imaging agent;immune checkpoint;Immuno-Chemotherapy;Immunohistochemistry;Immunosuppression;in vivo;ineffective therapies;Infiltration;Inflammatory;inhibitor;innovation;Institution;Life;Ligands;Liver;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;Monitor;monocyte;Morbidity - disease rate;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;participant enrollment;Patient imaging;Patient Selection;patient stratification;Patients;Peptides;Phase;Phase I/II Clinical Trial;Positron-Emission Tomography;pre-clinical;preclinical study;predicting response;prevent;Process;Production;Radiolabeled;radiological imaging;radiotracer;Regimen;Renal clearance function;Resectable;Resistance;response;Safety;Science;Screening procedure;Sensitivity and Specificity;Signal Transduction;Site;Specimen;targeted treatment;Testing;Therapeutic;Toxic effect;Tracer;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;Update;uptake;Variant;Work

PROJECT_TITLE: Novel CCR2 PET for Pancreatic Cancer Imaging and Prediction of Response to Standard and CCR2-Targeted Therapy

STUDY_SECTION: CMIP

STUDY_SECTION_NAME: Clinical Molecular Imaging and Probe Development[CMIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Social Determinants of Health

PI_NAMEs: GLENN, JASON EDWIN (contact)

PROJECT_TERMS: Address;Appropriateness Review;Area;Awareness;care delivery;Categories;Centers of Research Excellence;Clinical;Collaborations;Communities;community engaged research;community engagement;Competence;Complex;Consent;Consult;Consultations;Data;design;Discrimination;Disparity;Effectiveness;Equity;Ethics;Ethics Consultation;Evaluation;Exercise;experience;follow-up;Gender;Geography;Goals;Good Clinical Practice;Health;health care delivery;health care quality;health equity;health inequalities;Health system;Human;human subject;human subject protection;implementation research;implementation science;implicit bias;improved;Individual;Inequity;innovation;Institution;institutional capacity;Institutional Review Boards;investigator training;Lead;Leadership;Link;Medical;meetings;member;Mentors;Methods;Mind;novel;Performance;Pharmaceutical Preparations;Pilot Projects;Protocols documentation;Race;Regulation;Research;Research Design;Research Methodology;Research Personnel;research to practice;responsible research conduct;Schedule;Services;social determinants;structural health determinants;Structure;Training;Translating;Universities;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Implementation Science and Equity: Human Subjects & Regulatory (ETHICS) Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: GIBBS, HEATHER  (contact)

PROJECT_TERMS: 5 year old;Academy;Adoption;Adult;Affect;Age;American;Behavior;Behavioral;bilingualism;Body mass index;Calories;care providers;Caring;Carotenoids;Characteristics;Child;Child Care;Child health care;Childhood;Chronic Disease;Clinic;Communication;Communities;Counseling;cultural health;Data;design;Diet;Diet Habits;Dietary Intervention;disorder prevention;early childhood;Eating;Education;education resources;Effectiveness;effectiveness outcome;Equity;Ethnic Origin;evidence base;Family;Future;Goals;Health;health disparity;Health Food;health literacy;Healthy Eating;Hybrids;implementation evaluation;implementation science;improved;Individual;innovation;Instruction;Intervention;Latino;Life;life span;literacy;Maintenance;Measures;Methods;mHealth;novel;Nutrient;nutrition;nutrition education;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Parents;Patient Recruitments;Pattern;Pediatrics;Persons;pilot test;Play;Poverty;Preparation;Preschool Child;Preventive;preventive intervention;primary care clinic;programs;Promoting Action on Research Implementation in Health Services framework;Provider;psychosocial;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resources;Role;Rural Health;Sampling;satisfaction;Schools;skills;Skin;Spanish;Spanish/English;Structure;Techniques;Text Messaging;tool;Unhealthy Diet;uptake;Waiting Lists;Work

PROJECT_TITLE: Nutricity: A mHealth nutrition intervention to improve diet quality among Latino children


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Comparative Effectiveness Research;Dementia;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Palliative Care;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

PI_NAMEs: PERALES PUCHALT, JAIME  (contact)

PROJECT_TERMS: Address;Adherence;arm;caregiver stress;Caregiver support;Caregivers;caregiving;Caring;Centers of Research Excellence;Clinic;Communities;community engagement;Community Health Aides;Consolidated Framework for Implementation Research;Cues;culturally appropriate intervention;Dementia;dementia care;Dementia caregivers;depressive symptoms;design;Development;Disparity;Effectiveness;effectiveness trial;Emotional;Equity;evidence base;experience;Family;Family Caregiver;family caregiving;Feasibility Studies;feasibility testing;Goals;Health behavior;health disparity;Health education;implementation facilitators;implementation science;implementation strategy;Individual;Inequity;Intervention;Interview;Knowledge;Latino;Latino Population;Lead;learned behavior;Manuals;Mental Depression;Mentors;Methods;Modality;Modeling;Parents;Patients;Positioning Attribute;practice-based research network;pragmatic trial;Primary Care;primary care clinic;primary care provider;primary outcome;Provider;recruit;Resources;satisfaction;secondary outcome;Services;skills;social learning;Specific qualifier value;Stress;Stress and Coping;stress symptom;Structure;Support Groups;Testing;Training;trial design;Work

PROJECT_TITLE: Implementing a dementia caregiver support strategy among Latinos in primary care


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: SCHEUERMANN, TANEISHA SHANI (contact)

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;Administrator;arm;Behavioral;Biochemical;Birth;cancer risk;Carbon Monoxide;Carcinogens;Caring;Catalogs;Cellular Phone;Centers of Research Excellence;Child;child bearing;Clinic;Clinical;contingency management;cost;Counseling;Data;design;Devices;early childhood;Educational Materials;Effectiveness;Electronics;empowerment;Enrollment;Ensure;Equity;Exhalation;Family;Feedback;Female of child bearing age;follow-up;Goals;Guidelines;health equity;High Risk Woman;hybrid type 1 study;implementation facilitation;implementation intervention;implementation science;implementation strategy;improved;Incentives;Infant;informant;Information Systems;innovation;insight;Intervention;intervention program;intervention refinement;Intervention Studies;Interview;Low income;Malignant neoplasm of lung;Methods;mobile application;Modification;Monitor;mortality;non-smoker;novel;Participant;Persons;Pilot Projects;pilot trial;Population;preference;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal cigarette smoking;primary outcome;Process;programs;Psychological reinforcement;quitline;Randomized;Randomized, Controlled Trials;Recommendation;Reduce health disparities;remote assessment;remote delivery;Research;Resources;Risk;Sampling;screening;secondary outcome;Services;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking during pregnancy;smoking initiation;smoking prevalence;smoking relapse;Smoking Status;Spanish/English;Special Supplemental Nutrition Program for Women, Infants, and Children;Structure;Suggestion;support tools;System;Testing;Text;Text Messaging;text messaging intervention;Time;time use;Tobacco;Tobacco use;Training;trial design;United States;uptake;Visit;Woman

PROJECT_TITLE: Preliminary Studies on Implementation of Smoking Cessation Interventions for Low-Income Women


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: SMITH, SHARLA ANNETTE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;American College of Obstetricians and Gynecologists;Area;Aspirin;barrier to care;Birth;black patient;Black race;black women;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;Caring;Cessation of life;Child Care;Chronic;Clinic;Clinical;Computer software;cost;Counseling;Data;design;Dose;early onset;Education;Effectiveness;effectiveness evaluation;empowerment;Equity;evidence base;Evidence based program;Evidence based treatment;Feedback;Geography;Goals;Guidelines;Health;Health behavior;health care disparity;health disparity;High Risk Woman;Hybrids;Hypertension;hypertension control;implementation barriers;implementation evaluation;implementation measures;implementation outcomes;implementation science;improved;Incidence;Income;Individual;innovation;Insurance;Intention;Intervention;Low income;Maintenance;Maternal Health;Maternal Health Services;Maternal Mortality;medically underserved;medication compliance;metropolitan;Modeling;Monitor;novel;Outcome;Patient Self-Report;patient-level barriers;Patients;Perception;Persons;pilot test;Populations at Risk;Practical Robust Implementation and Sustainability Model;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy health;Pregnant Women;Prenatal care;prevent;preventable death;Prevention;Prevention trial;Process;programs;Proteinuria;Provider;provider-level barriers;racial disparity;Randomized;Recommendation;Recording of previous events;recruit;Reduce health disparities;Reproduction;Research;Research Design;Risk;Risk Factors;Rural;Self Care;Services;Site;telehealth;Telemedicine;Time;Transportation;treatment as usual;treatment disparity;trend;underserved area;Underserved Population;Uninsured;Visit;White Women;Woman;Work

PROJECT_TITLE: Improving the Quality of Prenatal Care for Low-Income, Black Women


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: PROJECT NARRATIVE The preschool age is a crucial period of growth and an optimal time to begin to establish healthy eating and physical activity habits leading to better food and activity choices into adulthood, thereby minimizing risk for obesity-related diseases and decreasing the cardiometabolic disparities in this Indigenous population. More Outside Your Door is a multi-level, randomized, stepped-wedge intervention trial designed to reduce the disparity of childhood obesity in Yup’ik Alaska Native children by increasing the proportion of nutrient-dense traditional and traditional-like foods consumed and increasing physical activity, particularly outdoor activities related to traditional Yup’ik subsistence and lifestyle practices. This 5-year intervention trial targeting 3-5 year olds is conducted in partnership with Rural Action Community Action Program Head Start programs in 12 rural Alaskan communities, where each site is assigned annually to a wedge group to receive either a community-altered culturally-tailored traditional foods and activities curriculum intervention or the standard regional Head Start program intervention.

PI_NAMEs: STILLWATER, BARBARA JANOAH (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: 3 year old;5 year old;actigraphy;Adherence;Adolescent;Adoption;Adult;Age;Alaska;Alaska Native;Alaska Native population;Alaskan;Back;Behavioral;Body mass index;built environment;Carbon;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular Pathology;cardiovascular risk factor;Child;Child Care;Child Health;Childhood;Chronic Disease;Clinical;Clip;Communities;Community Actions;community based participatory research;Community Participation;Consumption;Control Groups;COVID-19;COVID-19 pandemic;Data;Data Collection;design;Development;Diet;Diet Habits;Discrimination;Disparity;disparity reduction;Dissemination and Implementation;Early Intervention;Education;Educational Curriculum;Effectiveness;effectiveness testing;Elderly;empowerment;Enrollment;Ensure;ethnic minority population;Evidence based intervention;Exercise;experience;falls;Family;Feedback;Food;food consumption;forging;Funding;good diet;group intervention;Growth;Guidelines;Habits;Head Start Program;Health;Healthy Eating;Hemoglobin concentration result;Home;Hour;Hypertension;improved;Individual;Intervention;intervention program;Intervention Trial;Isotopes;Life;life span;Life Style;lifestyle intervention;Masks;Measures;member;Methods;migration;Morbid Obesity;Native-Born;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;Nursery Schools;Nutrient;Obesity;Obesity associated disease;obesity in children;obesity prevention;obesity risk;Outcome Measure;Overweight;Parents;Physical activity;Play;poor sleep;Preschool Child;Prevalence;prevent;primary outcome;Process;process evaluation;Program Effectiveness;Program Evaluation;programs;Qualitative Methods;racial minority population;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research Personnel;Resources;Risk Factors;risk minimization;Rural;rural Alaska;rural area;Schedule;school closure;School-Age Population;Schools;screening;Sea;Seasons;secondary outcome;Signal Transduction;Site;Sleep;sleep health;sleep quantity;stable isotope;statistics;Structure of nail of finger;success;sugar;System;Taste Perception;Taste preferences;teacher;Testing;Time;Travel;trial design;tribal health;Tribes;Unhealthy Diet;uptake;Yukon Kuskokwim;Yup'ik

PROJECT_TITLE: More Outside Your Door (MOYD)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Canine hookworm is a serious parasite of dogs and can cause several zoonotic diseases in humans. A strain of dog hookworm that is resistant to all approved deworming drugs is currently spreading through the pet population in the USA. We propose to infect small rodents with hookworm to establish a model for testing of new drugs to combat these dangerous parasites.

PI_NAMEs: HAWDON, JOHN M (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;Ancylostoma caninum;Anemia;Animal Model;Animals;Anthelmintics;canine model;Canis familiaris;Cessation of life;Child;combat;cost;cost effective;Cutaneous;Dangerousness;Developing Countries;Development;Diffuse;Disease;Dose;Drug Screening;Drug usage;efficacy testing;Enteritis;Ethics;Exploratory/Developmental Grant;Food;Future;gastrointestinal;genetic resistance;Goals;Hamsters;high reward;high risk;Hookworm Infections;Hookworms;Human;Immune system;immunodeficiency;immunosuppressed;In Vitro;in vitro activity;Infection;Infrastructure;insight;Intestinal parasite;Jird;Laboratory Animals;Larva Migrans;Link;Livestock;Modeling;Molecular;Morbidity - disease rate;Multi-Drug Resistance;Mus;Nature;Nematoda;Neuroretinitis;novel;novel therapeutics;Parasites;Parasitic nematode;permissiveness;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Predisposition;Prevalence;programs;Race;Rattus;Reproduction;Resistance;Rodent;Rodent Model;Sanitation;Specificity;STAT6 gene;Testing;Vaccines;Vulnerable Populations;Water;Zoonoses

PROJECT_TITLE: Development of a rodent model for anthelmintic testing against multidrug resistant hookworms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE - Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL) Our proposal builds on our original R01 by advancing analytical chemistry and computational techniques to characterize more fully the prenatal chemical exposome and its links to adverse maternal and perinatal health outcomes. For our renewal project, we propose to expand our study population by analyzing an additional 750 2nd trimester pregnancy samples, 300 of the samples matched to our original 3rd trimester samples and use an improved nontargeted analysis workflow to identify and quantify novel exogenous and endogenous chemical exposures. We will use new computational approaches to quantify concentrations of ~500 chemicals and evaluate relationships between multiple exogenous chemical exposures, endogenous effect biomarkers, and maternal and perinatal health outcomes, focusing on gestational diabetes and adverse pregnancy outcomes, providing unprecedented data to inform public health interventions to prevent harmful chemical exposures.

PI_NAMEs: WOODRUFF, TRACEY J. (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Acceleration;Address;advanced analytics;adverse maternal outcomes;adverse pregnancy outcome;Affect;Analytical Chemistry;analytical method;analytical tool;Binding;Biological;Biological Markers;Biological Monitoring;Birth Weight;Blood;Blood specimen;Chemical Exposure;chemical group;Chemicals;Complex;Computational Technique;Computer software;computerized tools;Computing Methodologies;Concentration measurement;dashboard;Data;Data Analyses;data integration;data tools;Databases;Development;Disease;environmental chemical;Environmental Exposure;Evaluation;Exposure to;fetal;Gestational Age;Gestational Diabetes;Goals;Health;Human;improved;Late pregnancy;Left;Link;lipid metabolism;Low Birth Weight Infant;machine learning algorithm;Mass Spectrum Analysis;Maternal Health;maternal serum;Measurement;Measures;metabolome;Methods;Modeling;Newborn Infant;novel;novel strategies;open source;Outcome;Output;Participant;Pathway interactions;Pattern;perinatal health;perinatal outcomes;personal care products;Persons;Phenotype;Plastics;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Predisposition;Pregnancy;Pregnancy Outcome;Pregnancy Trimesters;pregnant;Premature Birth;prenatal;prenatal exposure;Prevalence;prevent;Production;public health intervention;Regulation;Research;Resolution;Risk;Rubber;Sampling;Second Pregnancy Trimester;Serum;Shotguns;Siloxanes;Software Tools;Source;Stains;study population;Supercomputing;surfactant;Techniques;Technology;Third Pregnancy Trimester

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Pediatric;Rare Diseases;Women's Health Research

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: Project Narrative Statural growth impairment is an important complication of pediatric Crohn’s disease and is found in up to 80% of patients. One potential avenue for understanding the pathogenesis of impaired growth in Crohn’s disease is that it is more common in males. Understanding these sex differences will enable us to develop highly needed personalized sex-specific risk-based medical treatment strategies for pediatric Crohn’s disease.

PI_NAMEs: GUPTA, NEERA  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adult;Age;Anti-Inflammatory Agents;Biological;Biological Markers;bone age;Characteristics;Child;Childhood;Chronology;Clinical;clinical practice;cohort;Complication;Crohn's disease;cytokine;Data;Data Analyses;Data Set;differential expression;Disease Marker;disorder control;Endocrine;Epiphysial cartilage;Etiology;Female;Genetic;Genome;genome wide association study;genome-wide;Genotype;Gonadal Steroid Hormones;Gonadotropins;Growth;Harvest;Height;high risk;Hormones;hypothalamic pituitary gonadal axis;IL8 gene;Impairment;improved;Inflammation;Inflammatory;insight;Institution;Insulin-Like Growth Factor I;Interferon Type II;Interleukin-6;Investigation;Lead;Longitudinal Studies;male;Mediating;Medical;microbiome;Modeling;Molecular;nutrition;Pathogenesis;Pathway interactions;Patient risk;Patients;Pediatric Crohn's disease;Pharmaceutical Preparations;Phenotype;polygenic risk score;predictive modeling;Predisposition;prospective;Proteins;Proteome;Proteomics;Publishing;Refractory;response;Risk;risk stratification;Serum;sex;Sex Differences;Somatotropin;Standardization;targeted treatment;Testing;theories;Therapeutic;trait;treatment strategy

PROJECT_TITLE: Sex Differences in Statural Growth Impairment in Pediatric Crohn's Disease: Part 2

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Telomere shortening drives genome instability in aging and cancer. The shortening process is tightly monitored to prevent a DNA damage response and premature cell cycle arrest. Mechanistic understanding of this process and the role of RNA will provide insights to prevent premature senescence in aging cells and to promote premature death in ALT cancer cells.

PI_NAMEs: SMITH, SUSAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Aging;arm;Binding;cancer cell;cell age;Cell Aging;Cell Cycle Arrest;cell type;Cells;Centromere;Cessation of life;Chromosomal Stability;Chromosomes;cohesin;cohesion;daughter cell;Deposition;DNA Damage;Ensure;Genetic Recombination;genome integrity;Genomic Instability;Goals;Growth;Human;insight;Maintenance;Malignant Neoplasms;Mediating;Mitosis;Monitor;Normal Cell;Pathologic;premature;prevent;Prevention;Process;protein complex;Proteins;Proteome;recruit;repaired;Repetitive Sequence;Research;Resolution;response;RNA;Role;S phase;senescence;Sister;Sister Chromatid;Structure;Tankyrase;Telomerase;telomere;Telomere Shortening;TERF1 gene;Time;Work

PROJECT_TITLE: Mechanisms of Telomere Cohesion

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE  Head and neck cancer is a serious, debilitating type of cancer for which better approaches are needed in terms of both prevention and treatment. We have already shown that certain drugs that act in the vitamin A pathway can prevent head and neck cancer in a mouse model of this disease that closely mimics human cancer. We now want to figure out how these drugs work on stem/progenitor cells in the oral cavity epithelia to prevent these cancers from developing.

PI_NAMEs: GUDAS, LORRAINE J (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: 3-Dimensional;4 hydroxynonenal;4-Nitroquinoline-1-oxide;Affect;Agonist;Air;All-Trans-Retinol;Antibodies;Area;Bexarotene;Bioinformatics;Body Weight;cancer diagnosis;cancer initiation;cancer prevention;cancer stem cell;cancer therapy;cancer type;carcinogenesis;Carcinogens;Carcinoma;Cells;cellular retinoic acid binding protein;Cellular Retinol Binding Protein;Chemopreventive Agent;chemotherapy;chromatin immunoprecipitation;Clinical Treatment;Clinical Trials;Collaborations;Data;daughter cell;Diagnosis;disease model;Doxycycline;draining lymph node;drug action;Epithelial Cells;epithelial stem cell;Esophageal Squamous Cell Carcinoma;experience;experimental study;Faculty;Frequencies;Funding;Gene Expression Profile;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and Neck Surgery;high risk;high risk population;Histone Deacetylase;Human;Immunohistochemistry;improved;in vivo;indexing;Knock-out;lecithin-retinol acyltransferase;Ligands;Liquid substance;Malignant Neoplasms;Medical;Medicine;meetings;member;Modeling;Morbidity - disease rate;mortality;mouse model;mouth squamous cell carcinoma;Mus;Neoplasm Metastasis;NGFRAP1 gene;novel;Oncologist;Operative Surgical Procedures;oral cancer prevention;Oral cavity;oral cavity epithelium;Oral Leukoplakia;Otolaryngology;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Precancerous Conditions;prevent;Prevention;Prevention approach;Prevention therapy;professor;Prognosis;Proliferating;Property;Publications;Publishing;Radiation;Radiation therapy;Reactive Oxygen Species;recruit;Recurrence;Relapse;Research;Research Personnel;Retinoic Acid Receptor;retinoic acid receptor gamma;Retinoic Acid Response Element;Retinoids;Running;RXR;Site;Skin;Squamous cell carcinoma;stem cells;Stratified Squamous Epithelium;success;Survival Rate;System;Tamoxifen;targeted treatment;Testing;Training;transcription factor;Transgenes;Transgenic Mice;Transgenic Organisms;Treatment Protocols;Tretinoin;tumor;Tumor Suppressor Proteins;United States National Institutes of Health;Universities;Vitamin A;Work

PROJECT_TITLE: CD 1530, an RAR Gamma Agonist for Oral Cavity Squamous Cell Carcinoma Prevention

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE There are major disparities in health research and treatment across ancestry groups. Specifically, “admixed” people – those whose DNA contains more than one ancestral component, including African American and Latinx individuals – are systemically excluded from studies due to the lack of available methods to appropriately handle their complex genomes. In this award, I propose to bridge this concerning gap in research space by developing novel computational and statistical methods to enable the study of complex phenotypes in admixed people, bettering our understanding of the genetic basis for clinically-meaningful traits in these diverse populations who have so far been understudied and underserved.

PI_NAMEs: ATKINSON, ELIZABETH GRACE (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Acceleration;Accounting;Address;Admixture;Affect;African American;All of Us Research Program;Alleles;American;Asthma;Award;Awareness;Benchmarking;biobank;Cardiovascular Diseases;career;Clinical;clinical translation;cloud based;cohort;Collection;Complex;computer framework;Computer software;Computing Methodologies;Data;Data Collection;Development;Development Plans;Diabetes Mellitus;Disease;Distal;diversity and inclusion;DNA;empowerment;Ensure;Environment;Equity;European;Exclusion;experience;Face;flexibility;Frequencies;Functional disorder;gene discovery;gene interaction;Genes;Genetic;genetic architecture;Genetic Drift;genetic element;Genetic study;Genetic Variation;Genome;genome wide association study;Genomic medicine;genomic tools;Genomics;Goals;Guidelines;Haplotypes;health disparity;improved;in silico;Individual;innovation;large scale data;Latinx population;Linkage Disequilibrium;Malignant Neoplasms;Maps;Medical;Medical Genetics;Methodology;Methods;Minority;Minority Groups;Mission;Modeling;Molecular;molecular targeted therapies;National Human Genome Research Institute;Nature;novel;Outcome;Outcome Study;Persons;Phase;Phenotype;Population;Population Heterogeneity;population stratification;Positioning Attribute;Post-Traumatic Stress Disorders;rare variant;Recommendation;Research;Research Personnel;Resolution;Resources;Sampling;Signal Transduction;simulation;Site;Software Tools;Statistical Methods;statistics;Structure;success;Testing;tool;tool development;Training;trait;trend;Underrepresented Populations;United States National Institutes of Health;Variant;Work;years lived with disability

PROJECT_TITLE: Empowering gene discovery and accelerating clinical translation for diverse admixed populations


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States, governed by profound disparities in disease aggressiveness, incidence, and mortality. This proposal will perform correlative studies in novel preclinical models and high-risk human prostate cancer to identify previously unrecognized mitochondrial genomic and functional alterations in aggressive prostate cancer. These studies will ultimately result in new precision prostate cancer interceptions that can potentially improve the survival and reduce morbidity in high-risk populations.

PI_NAMEs: PAPACHRISTODOULOU, ALEXANDROS  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Advisory Committees;Affect;African American;anti-cancer research;Anti-diabetic Drugs;Antineoplastic Agents;Automobile Driving;Award;Biological Assay;Biological Markers;biomarker discovery;biomarker driven;cancer biomarkers;Cancer Etiology;cancer health disparity;carcinogenicity;career;career development;Cessation of life;Clinical Research;clinically relevant;cohort;Correlative Study;Data;Data Set;Development;Development Plans;Diagnosis;Disease;Disease Outcome;Disparity;DNA Sequence Alteration;efficacy evaluation;Etiology;experience;Functional disorder;Genes;Genetic;Genetic Markers;Genetically Engineered Mouse;Genome;Genomics;Goals;high risk;high risk men;high risk population;Human;improved;In Vitro;Incidence;innovation;insight;Intervention;Investigation;Knowledge;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metformin;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial dysfunction;mitochondrial genome;mitochondrial metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;NKX3-1 gene;novel;Nuclear;Oncogenic;Organoids;Outcome;Oxidative Phosphorylation;patient stratification;Patients;personalized approach;Population Group;Pre-Clinical Model;Prognosis;prognostic value;progression risk;prostate cancer progression;prostate cancer risk;Prostatic;Publishing;racial disparity;racial population;Research;Research Personnel;response;Risk;Role;screening;skills;specific biomarkers;Stress;Structure of base of prostate;tool;Training;trait;tumor;United States;Universities;Work

PROJECT_TITLE: Investigating mitochondrial dysfunction in high-risk prostate cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative A growing number of patients with advanced heart failure are undergoing left ventricular assist device (LVAD) implantation around the world. Patients supported by an LVAD demonstrate low physical activity and capacity and high rates of frailty and sarcopenia, which are associated with increased morbidity and mortality. We propose a randomized, multicenter clinical trial of 80 patients newly implanted with an LVAD to study the effects of a 6-month home-based exercise program using mobile technology on physical activity and capacity, frailty and sarcopenia, and quality of life.

PI_NAMEs: VIDULA, HIMABINDU  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Cardiac rehabilitation;Cardiomyopathies;chest computed tomography;Cities;Cost Analysis;Cost Savings;Costs and Benefits;Data;Enrollment;Exercise;exercise intervention;exercise physiologist;exercise prescription;exercise program;exercise rehabilitation;Exertion;frailty;group intervention;Health;Health Care Rationing;health care service utilization;Heart failure;high risk population;Home;Hospitals;Implant;implantation;improved;indexing;innovation;intervention cost;Kansas;left ventricular assist device;Measures;mechanical circulatory support;mobile computing;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;Muscle;muscle strength;novel;Operative Surgical Procedures;Participant;Patient Participation;patient population;Patients;Pectoralis Muscles;Physical activity;Physical Capacity;Pilot Projects;Population;Protocols documentation;Quality of life;Questionnaires;Randomized;reduced muscle strength;Rehabilitation therapy;Reporting;sarcopenia;Scanning;smartphone application;Standardization;Testing;Time;treatment as usual;video chat;Walking;wearable device

PROJECT_TITLE: Home-based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-Q(02)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Health Services;Mental Health;Orphan Drug;Palliative Care;Patient Safety;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: In today's healthcare system, there is a critical need to support and better prepare family caregivers of individuals with cancer for the pivotal role they play in attaining positive patient outcomes during rigorous treatment. The proposed research will test a unique, multicomponent caregiver intervention that incorporates simulation, a commonly used strategy in training of healthcare professionals, to allow family caregivers to practice technical and communication skills in a safe and supportive learning environment. The goals are to improve caregiver physical and emotional well-being, increase confidence for caregiving, and improve patient outcomes related to health-related quality of life and care events during treatment.

PI_NAMEs: MAZANEC, SUSAN  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: Active Learning;Address;Adverse event;Affect;Aftercare;Anus;Anxiety;Cancer Center;Cancer Family;cancer therapy;care delivery;care recipients;caregiver education;caregiver interventions;Caregivers;caregiving;Caring;chemotherapy;Clinical;clinical practice;Colostomy Procedure;Combined Modality Therapy;Communication;Complex;Comprehensive Cancer Center;Control Groups;cost comparison;Data;Decision Making;Dehydration;Demographic Factors;design;Distress;Division of Cancer Control and Population Sciences;Education;educational atmosphere;Educational Intervention;Educational process of instructing;Effectiveness;Emergency department visit;Emotional;Enteral Feeding;Esophagus;Event;experience;Face;Family;family building;Family Caregiver;family management;Family member;Fatigue;Feeling;Functional impairment;Goals;Head and Neck Cancer;Head and neck structure;Health;health care service utilization;Health Professional;health related quality of life;health training;Healthcare Systems;Hospitalization;Hour;Impairment;improved;Individual;Interruption;Intervention;intervention effect;IV Fluid;Lead;Location;Malignant neoplasm of anus;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Malnutrition;Measures;Mediating;Mediation;Medical Care Team;Mental Depression;Methods;Mission;Modality;Modeling;National Cancer Institute;Non-Small-Cell Lung Carcinoma;novel;Nutritional;Oncology;Operative Surgical Procedures;Outcome;Pain management;Patient Care;Patient-Focused Outcomes;Patients;Persons;pilot test;Play;point of care;Population;Preparation;primary caregiver;Problem Solving;Process;Prognosis;prospective;psychoeducation;psychoeducational intervention;psychological distress;Psychosocial Influences;Quality of Care;Radiation;Radiation therapy;randomized trial;Randomized, Controlled Trials;recruit;Rectal Cancer;Rectum;Reporting;Research;Role;Self Efficacy;Self Management;simulation;skill acquisition;skills;skills training;Skin;Structure;survivorship;Symptom Burden;symptom management;Symptoms;Techniques;Telephone;Testing;Time;Tracheostomy procedure;Training;Translating;Treatment outcome;Treatment Side Effects;University Hospitals;usual care arm;virtual;Well in self;wound

PROJECT_TITLE: Building Family Caregiver Skills Using a Simulation-Based Intervention for Care of Patients with Cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE (Overall) Cardiometabolic diseases are a significant public health problem in the US and have a disproportionate impact on the residents of Louisiana. This COBRE Phase 2 application aims to further develop and strengthen the clinical and translational research infrastructure at Tulane University and to continuously expand and support a critical mass of investigators with expertise in clinical and translational research in cardiometabolic diseases. The proposed COBRE program will ultimately contribute to reducing the burden of cardiometabolic diseases and improving the health of individuals and the public in Louisiana and beyond.

PI_NAMEs: MILLS, KATHERINE TERESA (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;Adult;Amylases;Apolipoproteins;Bioinformatics;biomarker identification;Biostatistics Core;black patient;Black race;Blood Pressure;Carbohydrates;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;Centers of Research Excellence;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinic;Clinical;clinical center;clinical practice;Clinical Research;Clinical Sciences;Cohort Studies;Collaborations;Communities;community engagement;Copy Number Polymorphism;Core Facility;cost;Data;Death Rate;Deceleration;Detection;Diabetes Mellitus;diabetes risk;Diagnostic;disease disparity;Disease Progression;disorder prevention;double-blind placebo controlled trial;ethnic disparity;evidence base;extracellular vesicles;Faculty;Financial Support;Fostering;Funding;Funding Agency;Gene Dosage;Generations;genetic variant;Grant;Guidelines;Health;health disparity;Health Policy;Heart;Hyperglycemia;Hypertension;improved;Individual;innovation;Intake;interdisciplinary collaboration;Interdisciplinary Study;Kidney Diseases;Knowledge;Leadership;Louisiana;Mediating;member;Mentorship;Metabolic;metabolomics;Methodology;Molecular;mortality;multidisciplinary;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Paper;Participant;Patient Care;peer;Peer Review;Phase;Pilot Projects;Play;Population;Positioning Attribute;Potassium;Productivity;Program Development;programs;Public Health;Publishing;racial disparity;Randomized;Randomized, Controlled Trials;recruit;Research;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Support;response;Risk Factors;risk variant;Role;Scientist;Socioeconomic Status;square foot;success;Supplementation;Teacher Professional Development;tenure track;Testing;Training;Translational Research;translational scientist;United States National Institutes of Health;Universities

PROJECT_TITLE: Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: HE, JIANG  (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Award;Bioinformatics;Biostatistics Core;Budgets;Cardiometabolic Disease;cardiometabolism;career development;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Committee Members;Communication;community engagement;Core Facility;cost;Detection;Diagnostic;Ensure;Evaluation Research;Expenditure;Faculty;Funding;Funding Opportunities;Goals;Grant;Growth;Health;improved;Individual;Infrastructure;interdisciplinary collaboration;interest;International;Louisiana;meetings;Mentors;Mentorship;Molecular;multidisciplinary;National Institute of General Medical Sciences;Paper;peer;Peer Review;Performance;Phase;Pilot Projects;Play;Positioning Attribute;Preparation;Process;Productivity;programs;Publications;Publishing;recruit;Regulation;Reporting;Research;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Role;Strategic Planning;success;Translational Research;translational research program;translational scientist;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: As an intermediate regulatory paradigm between DNA sequences and gene expression, epigenetic mechanisms can exert substantial influence on normal brain function. Increasing evidence indicates that multiple neurodevelopmental, neurodegenerative, and psychiatric disorders are caused, at least in part, by aberrant epigenetic modifications. We will integrate various disciplines to understand dynamic DNA modifications during neurodevelopment and aging as well as their dysregulation in the pathogenesis of human diseases.

PI_NAMEs: JIN, PENG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adenosine;Aging;Biochemistry;Bioinformatics;Brain;Cellular biology;Central Nervous System;Cytosine;Development;Discipline;Disease;DNA;DNA Methylation;DNA Modification Process;DNA Sequence;DNA-Protein Interaction;Epigenetic Process;Gene Expression;Gene Expression Regulation;gene function;Genetic;Genetic Transcription;Genomics;Heritability;human disease;Hydroxylation;Learning;mammalian genome;Memory;Mental disorders;Methylation;Modification;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;novel;Pathogenesis;Process;Protein Family;Regulation;Role;Tetanus Helper Peptide;Work

PROJECT_TITLE: Dynamic DNA Modifications in Brain and Diseases


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: CHEN, JING  (contact)

PROJECT_TERMS: Adoption;Biochemical;Bioinformatics;Biostatistics Core;Blood;Businesses;Cardiometabolic Disease;Centers of Research Excellence;Clinic;Clinical;clinical infrastructure;Clinical Research;Collection;Communities;community advisory board;community engagement;cost;Data Collection;Development;Diagnosis;Dissemination and Implementation;Ensure;Equipment;Etiology;Farm;Fees;Funding;Future;Goals;Grant;Healthcare;Hurricane;implementation research;improved;Individual;Institutional Review Boards;International;Intervention;intervention delivery;Laboratories;Manuals;Multi-Institutional Clinical Trial;Nursing Research;operation;Paper;participant retention;Patient Recruitments;Peer Review;Phase;Pilot Projects;Play;population health;Preparation;Prevention;Procedures;programs;protocol development;Protocols documentation;Publishing;quality assurance;Quality Control;real world application;recruit;Research;research facility;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resources;Role;Sampling;Services;Specimen;success;Training;translational pipeline;Translational Research;translational research program;translational study;United States National Institutes of Health;Universities;Urine;Visit

PROJECT_TITLE: Clinical Research and Community Engagement Core


ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Project Narrative The objective of this Phase 2 COBRE is to (1) support four independent, but complementary research projects initiated by all early-stage/new investigators on host-pathogen interactions (HPI); (2) continue and expand administrative and infrastructural support by nurturing the existing and new core facilities that are essential to our COBRE group as well as to other biomedical researchers within and outside of UND; (3) implement individualized mentoring program and career development opportunities for our junior investigator to achieve independence and attain national/international recognition. Successful completion of these aims in Phase 2 will solidify the independent, nationally recognized status of the HPI COBRE composed of a group of investigators exploring novel areas of host-microbe interactions in human health and disease.

PI_NAMEs: BRADLEY, DAVID S. (contact);BRISSETTE, CATHERINE AYN

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acute;Affect;airway epithelium;anti-cancer research;Area;Bacterial Infections;Behavior Disorders;Big Data;Businesses;career development;career networking;Centers of Research Excellence;chronic inflammatory disease;Communicable Diseases;Communities;Core Facility;Data Analyses;design;Development;Disease;dysbiosis;Ensure;Epigenetic Process;equipment acquisition;experimental study;Extramural Activities;Faculty;Flow Cytometry;Focus Groups;Food Hypersensitivity;Fostering;Funding;gastrointestinal;Genomics;Giardia;Goals;Grant;Growth;gut microbiota;gut-brain axis;Health;Histology;host-microbe interactions;Human;Image;Immune response;Individual;Infection;Inflammation;Inflammatory;innovation;Interdisciplinary Study;interest;International;Intestines;Investigation;Light;Mentors;microbiome;Mucous Membrane;multidisciplinary;Neurodegenerative Disorders;novel;Parasites;Parasitic Diseases;Parasitic infection;pathogen;Phase;Predisposition;Process;Program Development;programs;Publications;Qualifying;Research;Research Infrastructure;Research Personnel;Research Project Grants;respiratory;Respiratory syncytial virus;SARS-CoV-2 infection;Science;Scientist;Stream;success;Support Groups;Surface;Talents;Viral;Virus Diseases;Vision

PROJECT_TITLE: Center for Excellence in Host Pathogen Interactions


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PHR: Narrative  The Administrative Core of this Phase 2 COBRE will provide oversight support to Core service providers and  junior investigators focused on determining the mechanisms underlying immune modulations in the host upon  interaction with various microbes. Our long-term goal is to identify possible treatments for devastating  inflammatory diseases.

PI_NAMEs: COMBS, COLIN K (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Big Data;Bioinformatics;biomedical scientist;career;career development;Career Mobility;Cell Separation;Center for Translational Science Activities;Centers of Research Excellence;Clinic;Clinical;clinical translation;Collaborations;Collection;Core Facility;COVID-19 testing;Data Analyses;Dedications;Disease;education resources;Ensure;Epigenetic Process;Evaluation;Event;Extramural Activities;Flow Cytometry;Fostering;Funding;Goals;Graduation Rates;Grant;Grant Review;Grooming;gut dysbiosis;Hand;Health;Health Sciences;high throughput analysis;Histology;host-microbe interactions;Human;Image;Image Cytometry;Immune response;immunoregulation;Individual;Inflammatory;Journals;medical schools;meetings;member;Mentors;Microbe;microbial community;Nature;North Dakota;novel;Outcome;pandemic disease;pathogen;pathogenic bacteria;pathogenic virus;Peripheral;Phase;Productivity;Program Development;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;retention rate;Sampling;Series;service providers;Services;success;Support Groups;symposium;Therapeutic;United States National Institutes of Health;Work


PI_NAMEs: KELLY, TANIKA NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Bioinformatics;Biomedical Research;Biometry;Biostatistics Core;Cardiometabolic Disease;Centers of Research Excellence;Clinical;clinical care;Clinical Research;Communities;complex biological systems;complex data;Computational Technique;computer infrastructure;computing resources;Core Facility;Data;Data Analyses;data management;data quality;Data Set;data structure;Dedications;disorder prevention;Educational workshop;empowerment;Ensure;Fees;Funding;Funding Agency;Goals;Grant;high dimensionality;Individual;Interdisciplinary Study;Manuscripts;Measures;Mentorship;Methodology;Methods;Molecular;multidimensional data;novel;Peer Review;Phase;Pilot Projects;programs;protocol development;Public Health Practice;Publishing;Quality Control;randomized, clinical trials;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;Scientific Inquiry;Services;skills;Statistical Data Interpretation;success;Technology;tool;Training;training opportunity;Translating;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Bioinformatics and Biostatistics Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative Exosomes are nano-sized extracellular vesicles that are naturally present in the blood and all organs, and they are secreted by all cells. The origin and function/s of exosomes in normal physiology and cancer progression remains largely unknown, and challenged by the need for precise methodologies for their purification and characterization, and the need for new genetic mouse models for in vivo evaluation. This program is designed to understand the functional contribution of exosomes in normal physiology and in pancreatic cancer, with a focus on developing new diagnostic and therapy options.

PI_NAMEs: KALLURI, RAGHU  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Address;Area;Biogenesis;Biology;Blood;cancer cell;Cell membrane;Cell secretion;Cells;Clinical;Complex;design;Diameter;Disease;Endosomes;engineered exosomes;Engineering;exosome;extracellular;extracellular vesicles;Genetic;Genomic DNA;in vivo;in vivo evaluation;intercellular communication;Lipid Bilayers;Lipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Messenger RNA;Methodology;MicroRNAs;mouse model;Mus;nanosized;neoplastic cell;novel;novel diagnostics;novel therapeutics;Oncogenes;Organ;Pathogenesis;Pathology;Physiology;Production;Prognosis;programs;Proteins;Research;Role;Source;Therapeutic Intervention;Tissues;trafficking;translational applications;translational potential;treatment response;Tropism;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;United States;Untranslated RNA

PROJECT_TITLE: Biology and Function of Exosomes in Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Nanotechnology;Precision Medicine;Prevention

PI_NAMEs: HU, TONY Y. (contact)

PROJECT_TERMS: Address;Analytical Chemistry;analytical method;APOL1 gene;Basic Science;Biochemistry;Biology;biomarker discovery;Biomedical Engineering;biophysical techniques;Biosensor;Biotechnology;Blood Pressure;blood pressure reduction;Cardiometabolic Disease;career development;Cells;Centers of Research Excellence;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical Research;Clinical Sciences;Collaborations;Communicable Diseases;Complex;Consultations;Core Facility;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Doctor of Philosophy;early detection biomarkers;Early Diagnosis;empowerment;Etiology;Evaluation;experience;Experimental Designs;Future;Genetic Markers;Goals;Human Resources;Image;Immune;Individual;Infrastructure;innovation;innovative technologies;Institution;instrument;instrumentation;Intake;Interdisciplinary Study;Knowledge;Louisiana;Mass Spectrum Analysis;Methodology;Methods;Molecular;Molecular Analysis;Molecular Biology;Molecular Diagnosis;molecular diagnostics;molecular marker;Monitor;Nanotechnology;novel;novel marker;organ on a chip;Overweight;Pathologic;personalized diagnostics;personalized medicine;Phase;Pilot Projects;point of care testing;Population Sciences;Potassium;Prevention;Process;professor;prognostic;programs;Proteome;Proteomics;real time monitoring;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Sampling;screening;Services;single cell analysis;skills;specific biomarkers;sustainable resource;synergism;Technology;Tissues;Training;Translational Research;treatment response;Universities;Whole Organism;X Inactivation

PROJECT_TITLE: Molecular Detection and Diagnostics Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Large amounts of molecular, neuroimaging, biomarker and clinical data have been generated in the context of Alzheimer’s disease (AD), but the wide range of causal factors for AD have not always been connected to the methods for tracking the disease etiology or to possible treatments. To process the diverse genetic causes of AD into useful information for other researchers, in this proposal we assemble an interdisciplinary team to develop and implement a robust artificial intelligence (AI) framework, namely AIM-AI, for transforming the genetic catalog of AD in a way that is Actionable, Integrated and Multiscale, so that genetic factors have clear utility for subsequent studies focusing on cognitive systems. The successful completion of this project will generate a robust AIM-AI framework, including machine learning methods and tools, resources, and scientific discoveries, which will be immediately shared with AD researchers and other complex disease research communities.

PI_NAMEs: GAITERI, CHRISTOPHER A.;JIANG, XIAOQIAN ;ZHAO, ZHONGMING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Accountability;Address;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Artificial Intelligence;artificial intelligence model;Autopsy;Awareness;Biological Markers;Brain;Brain region;brain tissue;Catalogs;cell type;Cells;Characteristics;Chromatin;Chromosome Mapping;Clinical;Clinical Data;Clinical Sciences;cognitive system;Communities;Complex;computational neuroscience;convolutional neural network;Data;Data Analyses;data curation;deep learning;deep learning model;design;Disease;disease diagnosis;disease phenotype;Disease Progression;disorder risk;DNA Methylation;DNA Sequence;drug development;drug discovery;epigenomics;Etiology;feature extraction;functional genomics;Gene Expression;Genetic;genetic analysis;genetic architecture;genetic association;Genetic Diseases;Genetic Risk;Genetic Transformation;genetic variant;genomic data;Genomics;Goals;Histone Acetylation;Image;imaging genetics;Impaired cognition;Individual;Informatics;Intercept;Joints;knowledgebase;Light;Link;Machine Learning;machine learning method;Mediating;Medical Imaging;Methods;MicroRNAs;Modality;Modeling;Molecular;Molecular Biology;multimodal data;Multiomic Data;multiple omics;neuroimaging;novel;Nucleic Acid Regulatory Sequences;Ontology;Pathology;Pharmaceutical Preparations;Phenotype;phenotypic data;Play;polygenic risk score;Population;Process;protein expression;Proteins;Proteome;Regulation;Research;Research Personnel;Resolution;Resources;response;risk variant;Role;Signal Transduction;single-cell RNA sequencing;System;Systems Analysis;Systems Biology;Time;Tissues;tool;Training;Translational Research;Validation;Variant

PROJECT_TITLE: AIM-AI: an Actionable, Integrated and Multiscale genetic map of Alzheimer's disease via deep learning


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: LI, CHANGWEI  (contact)

PROJECT_TERMS: adjudication;Affect;African American;African ancestry;Alleles;American;Apolipoproteins;Area;Articulation;bioinformatics tool;Biological;black patient;Black Populations;Black race;Bladder;Cardiometabolic Disease;Catalogs;Centers of Research Excellence;Cessation of life;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical Research;clinically significant;cohort;Cohort Studies;Complex;Cox Proportional Hazards Models;Data;Development;Disease Progression;disorder prevention;End stage renal failure;Environment;Equation;Etiology;Event;evidence base;experience;follow-up;Foundations;functional decline;Funding;Genes;Genetic Models;genomic data;Genotype;Glomerular Filtration Rate;high risk;high risk population;Hour;Human;Hypertension;Individual;innovation;Kidney;Kidney Diseases;Linear Regressions;Link;Measures;Mediating;Mediation;Metabolic Pathway;metabolome;metabolomics;Modeling;Molecular;multidisciplinary;Nephrons;new therapeutic target;novel;novel therapeutic intervention;Participant;Pathway interactions;Patients;Persons;Phenotype;Plasma;Population;Precision Health;premature;prevent;Process;programs;prospective;Public Health;Publishing;racial disparity;recessive genetic trait;Renal function;Research;Research Personnel;Risk;risk variant;Sampling;Testing;Therapeutic;Translational Research;urinary;Urine;Variant;Work

PROJECT_TITLE: Metabolomics Study of APOL1-Associated Chronic Kidney Disease Progression


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: DOYLESTOWN

ORG_NAME: CONIFER POINT PHARMACEUTICALS, LLC

PHR: Project Narrative The goal of this proposal is to provide drug researchers with compelling new tools that address off-target selectivity in the rational design of drugs. To do this, we propose to employ our large repository of maps of where chemical fragments tightly bind to 1,000’s of proteins (Boltzmann maps) in searches for differences in spatial binding patterns of fragments across proteins. This will empower medicinal chemists in attacking the off-target toxicity challenge that plagues clinical candidates in drug discovery.

PI_NAMEs: KULP III, JOHN LAURENCE (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Acceleration;Achievement;Address;Affinity;Algorithms;Benchmarking;Big Data;Binding;Binding Sites;Biological Sciences;Biotechnology;candidate identification;Capital;Case Study;Chemicals;Chemistry;clinical candidate;Clinical Trials;Cloud Computing;cloud platform;Cloud Service;Collection;commercialization;computational chemistry;Coniferophyta;Consumption;cost;Data;Data Set;Databases;design;DHFR gene;Doctor of Philosophy;Drug Design;drug discovery;Drug Targeting;empowerment;enzyme pathway;Evaluation;experience;Family;Family member;Feedback;Free Energy;Funding;Generations;Geometry;Goals;Grant;Hand;Homology Modeling;Image;improved;Individual;inhibitor;innovation;insight;Internet;Learning;Libraries;Maps;Medicine;Methodology;Modification;Mutation;open source;p38 Mitogen Activated Protein Kinase;Patients;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phosphotransferases;Phylogenetic Analysis;pre-clinical;priority pathogen;programs;protein data bank;Protein Family;Protein Fragment;protein protein interaction;protein structure;Proteins;prototype;PTGS1 gene;Publications;Publishing;rational design;repository;Research Personnel;Resources;Running;Sales;Sampling;scale up;Scientist;Services;simulation;SIRT1 gene;Sirtuins;Small Business Innovation Research Grant;Structure;success;Techniques;Technology;Therapeutic;therapeutic protein;therapeutic target;Time;tool;Toxic effect;Trees;United States National Institutes of Health;Validation;Visualization;Water;web app;web interface;web services;Work

PROJECT_TITLE: A Web Service for Fragment-based Selectivity Analysis of Drug Leads


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PHR: Narrative The Imaging Core will expand its microscopic imaging capabilities and services to support studies of the cellular and physiological mechanisms underlying host responses to pathogens by members of the Host- Pathogen COBRE program. The Core will also serve a broadening user base addressing research interests of the broader regional biomedical research community including Lyme disease, Alzheimer’s disease, drug addiction, depression, aging, and cancer to name only a few.

PI_NAMEs: GROVE, BRYON D (contact)

PROJECT_TERMS: 3-Dimensional;Address;Aging;Alzheimer's Disease;base;Biomedical Research;Cells;Centers of Research Excellence;Collaborations;Communities;Computer Workstations;Confocal Microscopy;Core Facility;Coupled;Data;Data Analyses;design;Development;Drug Addiction;Education;education resources;Educational workshop;Electron Microscope;Electron Microscopy;Equipment;experience;Experimental Designs;experimental study;Fees;Fiji;Fluorescence Microscopy;Funding;Goals;Grant;Health Sciences;Image;Image Analysis;imaging approach;imaging capabilities;Immune response;instrument;instrumentation;interest;intravital microscope;intravital microscopy;live cell imaging;Lyme Disease;machine learning algorithm;Malignant Neoplasms;medical schools;member;Mental Depression;Microscope;microscopic imaging;Microscopy;Mission;Modeling;multi-photon;Names;operation;Outcome;pathogen;Phase;Physiological;programs;quantitative imaging;Quantitative Microscopy;Records;Research;Research Activity;Research Personnel;Research Training;Scanning;Services;Software Tools;Specialist;System;Three-dimensional analysis;tool;Total Internal Reflection Fluorescent;Training;transmission process;Viral;web site;webinar;Writing

PROJECT_TITLE: Imaging Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Machine Learning and Artificial Intelligence;Obesity;Prevention

PI_NAMEs: FAN, JIA  (contact)

PROJECT_TERMS: Acceleration;Adipocytes;adipokines;Adipose tissue;Affect;Age;Appearance;Attenuated;Binding;Biological Assay;Biological Factors;Biological Markers;biomarker development;Body mass index;candidate marker;Cardiometabolic Disease;Cardiovascular Diseases;Cardiovascular system;Cells;Centers of Research Excellence;Chronic Disease;Circulation;Clinical;clinical application;Clinical Data;clinical practice;Clinical Research;clinical translation;Cohort Studies;Collaborations;cost;Detection;detection limit;Development;Diabetes prevention;diabetes risk;differential expression;Disease;Disease Progression;Distant;early detection biomarkers;Early Diagnosis;Early identification;Enrollment;Evaluation;Event;Exhibits;extracellular vesicles;follow-up;Friends;Functional disorder;Glucose;Glucose Intolerance;glucose metabolism;Glycosylated hemoglobin A;Heart;high risk;high risk population;Human;improved;Individual;Inflammatory Response;Innate Immune Response;innovation;Insulin Resistance;Investigation;Label;Lead;Louisiana;machine learning algorithm;machine learning model;Macrophage;Mass Spectrum Analysis;Measurement;Measures;Mediating;Membrane;Mentors;Mentorship;Metabolic Diseases;Metabolic syndrome;Methods;Modeling;Morbidity - disease rate;mortality;nanoGold;nanoparticle;nanoplasmonic;Non-Insulin-Dependent Diabetes Mellitus;novel;obese patients;obese person;Obesity;obesity development;obesity risk;Organ;Participant;Pathologic;Pathway interactions;Pattern;Peptide Hydrolases;Performance;Plasma;potential biomarker;Prediabetes syndrome;predictive marker;prevent;Procedures;Process;programs;progression risk;protein biomarkers;Proteins;Proteomics;Race;Reporting;Reproducibility;Research;Research Personnel;Resources;response;Risk;risk prediction;Sampling;Serum;sex;Signal Transduction;Standardization;Statistical Models;success;supervised learning;Symptoms;targeted biomarker;Therapeutic Intervention;Tissues;Translating;Translational Research;Translations;vesicular release

PROJECT_TITLE: Adipose Tissue-Derived Extracellular Vesicles as Early Biomarkers of Type 2 Diabetes


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This is a renewal application requesting further funding for our recently established Memorial Sloan Kettering Cancer Center (MSK) K12 training program. Through initial K12 funding we have successfully established a robust MSK K12 program for highly selected and motivated candidates from multiple relevant clinical departments at our center as well as other regional cancer training programs. Promised institutional matching funds has allowed and will continue to allow the center to double the number of trained clinical investigators, making the K12 Career Development Award a premier and highly ambitious training program at MSK and perhaps serve as a template of similar high output translational clinical investigator training programs at other academic centers.

PI_NAMEs: ABDEL-WAHAB, OMAR ;POWELL, SIMON N. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advertisements;Advisory Committees;Annual Reports;anti-cancer research;Appointment;Award;candidate selection;Clinical;Clinical Investigator;Clinical Oncology;clinical translation;design;Doctor of Philosophy;Educational Curriculum;Eligibility Determination;Evaluation;Faculty;fitness;Funding;graduate school;Institution;K-12 Education;K-Series Research Career Programs;Memorial Sloan-Kettering Cancer Center;Mentored Clinical Scientist Development Program;Mentors;Performance;Positioning Attribute;Program Reviews;programs;Progress Reports;Qualifying;Questionnaires;Recommendation;recruit;Research;Science;Site Visit;symposium;Time;Training Programs;translational cancer research;Translational Research;translational scientist;Writing

PROJECT_TITLE: MSK Paul Calabresi Career Development Award for Clinical Oncology

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: RELEVANCE Lesch-Nyhan disease is an inherited disorder caused by pathological genetic variants in the HPRT1 gene. A major uncertainly that has blocked attempts to rescue this disorder is uncertainty regarding the developmental age when treatments must be started to prevent or reverse its neurobehavioral defects. This project uses neurons growing in a dish, mouse models, and human brain samples to delineate the developmental stage at which treatments need to occur to rescue developing neurons.

PI_NAMEs: JINNAH, HYDER A (contact);VISSER, JASPER

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Age;Animal Model;Autopsy;Behavior;Biological;Brain;Brain Diseases;Cell Line;Cell model;Cerebral Palsy;Characteristics;Clinical;clinical phenotype;clinical translation;Clinical Trials;conditional knockout;Defect;Development;Disease;dopaminergic neuron;Embryonic Development;Environment;Enzymes;Event;Evolution;Experimental Models;Functional disorder;Gene Expression Profile;genetic variant;Gout;Hereditary Disease;HPRT1 gene;Human;human induced pluripotent stem cells;Hypoxanthine Phosphoribosyltransferase;Impulsivity;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Intellectual functioning disability;Intervention;Intervention Trial;Kidney Calculi;Knockout Mice;laser capture microdissection;Lead;Lesch-Nyhan Syndrome;male;mature animal;Mental Retardation;Metabolic;Midbrain structure;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;Morphology;motor impairment;mouse model;Mutation;Neurites;neurobehavioral;Neurodevelopmental Disorder;neuron development;Neuronal Dysfunction;Neurons;new therapeutic target;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Poverty;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Process;Production;Purines;restoration;Sampling;Self-Injurious Behavior;Source;Specimen;Stains;stem cell model;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;transcriptome sequencing;Translating;Tyrosine 3-Monooxygenase;Uncertainty;Uric Acid

PROJECT_TITLE: Rescue of Lesch-Nyhan Disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Genetics;Nutrition;Obesity;Prevention

PI_NAMEs: HEIANZA, YORIKO  (contact)

PROJECT_TERMS: Advanced Development;Amylases;Baseline Surveys;Biological Markers;biracial;Black race;Blood Glucose;blood glucose regulation;carbohydrate metabolism;Carbohydrates;Cardiometabolic Disease;Centers of Research Excellence;Clinical Research;Communication;Complex;Consensus;Copy Number Polymorphism;Data;Diet;Dietary Carbohydrates;Dietary intake;dietary starch;Digestion;digital;Disease;disorder risk;Distant;DNA;Endocrine;Energy Intake;Energy-Generating Resources;Ensure;Enzymes;epidemiology study;Exhibits;experience;Fasting;fasting glucose;fibroblast growth factor 21;follow-up;Funding;Genes;Genetic;Genomics;Genotype;global health;Glucose;glucose metabolism;Glycosylated hemoglobin A;Goals;Heart;Hormones;Hyperglycemia;Impairment;Individual Differences;insight;Insulin;Insulin Resistance;insulin secretion;Intake;Interdisciplinary Study;Life;Life Style Modification;Link;Louisiana;Macronutrients Nutrition;Measures;Mediating;Mediator;men;Metabolic;Metabolic Pathway;metabolomics;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Outcome;Pancreas;Paper;Participant;Pathway interactions;Patients;Plasma;Play;Prediabetes syndrome;Preventive;programs;prospective;Publishing;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Risk Reduction;Role;Salivary;Sample Size;Sampling;Starch;Surveys;Testing;Therapeutic;Time;Translational Research;United States;Variant;Woman

PROJECT_TITLE: Metabolic Pathways in Carbohydrate Digestion-Related Amylase Variation and Type 2 Diabetes


PHR: Narrative The Host-Pathogen Interaction (HPI) COBRE Histology Core Facility was established to provide high quality instrumentation, tissue preparation, staining, image analysis services, and training in a wide spectrum of fundamental and advanced histological techniques to COBRE research investigators. The Core also provides access and support to non-COBRE investigators within and outside the UND SMHS, as well as those from institutions adjoining (USDA-Grand Forks Human Nutrition Research Center) and in neighboring cities (North Dakota State University, North Dakota primarily undergraduate institutions and tribal colleges).

PROJECT_TERMS: analytical tool;Applications Grants;base;Biomedical Research;Businesses;Centers of Research Excellence;Certification;Cities;Communities;Core Facility;cost;Coupled;detection method;Drops;Ensure;Equipment;Experimental Designs;Fee-for-Service Plans;Fees;Floor;fluorescence imaging;Growth;Health Sciences;Histological Techniques;Histology;Human;Image;Image Analysis;improved;Infrastructure;Institution;Instruction;instrument;instrumentation;Investments;Maintenance;medical schools;meetings;member;Morphology;North Dakota;Nutritional Study;Outcome;pathogen;Pathologist;Phase;Preparation;Productivity;programs;Publications;Recommendation;Research;Research Personnel;Resolution;Resources;response;Safety;sample fixation;Sampling;Services;Slide;Stains;Structure;Students;Suggestion;Techniques;Tissue Banks;Tissue Fixation;tissue preparation;Tissue Sample;Tissues;Training;tribal college;undergraduate student;United States Department of Agriculture;United States National Institutes of Health;Universities;Veterinarians;Vision;whole slide imaging

PROJECT_TITLE: Histology Core