NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Resistance to antimicrobial agents limits treatment options for bacterial infections and is a major public health concern. Bacterial ribosome is a major antibiotic target. By modifying antibiotic binding site within the ribosome, enzymes responsible for resistance block binding of antibiotics, rendering them ineffective.

PI_NAMEs: FUJIMORI, DANICA GALONIC (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Adenosine;Amino Acyl Transfer RNA;anti-microbial drug;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Infections;Binding;Binding Sites;Biological Process;Chloramphenicol;Clinical;Complex;Consensus;cost;crosslink;Cryoelectron Microscopy;Directed Molecular Evolution;DNA Sequence Alteration;Elements;enzyme reconstitution;enzyme substrate;Enzymes;Escherichia coli;Family;Family member;fitness;florfenicol;Funding;Future;Gene Expression;Genes;Geographic Distribution;Gram-Negative Bacteria;hygromycin A;improved;In Vitro;in vivo;innovation;Investigation;lincosamide;Linezolid;Macrolides;member;Messenger RNA;methicillin resistant Staphylococcus aureus;Methods;Methylation;Mobile Genetic Elements;Modification;mutant;Mutation;Nature;next generation sequencing;nucleoside analog;Nucleotides;Open Reading Frames;Orphan;Oxazolidinones;pathogenic Escherichia coli;Peptides;Peptidyltransferase;Positioning Attribute;Property;Protein Family;Protein Synthesis Inhibition;Proteins;Public Health;reconstitution;Regulation;Resistance;resistance gene;resistance mechanism;Resolution;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA methylation;RNA, Ribosomal, 23S;Sequence Analysis;Site;Streptogramins;Testing;Translational Repression;Validation;Variant;Work

PROJECT_TITLE: Radical SAM-dependent methylation in antibiotic resistance

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This project will capitalize on an ongoing and well-established late life learning (LLL) program, the University for Seniors (UfS), in Beirut, Lebanon and will include 500 previously enrolled UfS participants, 200 participants to be newly enrolled in UfS, and 700 age- and sex- matched non-UfS-participating community residents. The resulting cohort will be prospectively followed and will include two waves of data collection to rigorously evaluate the relationships of LLL with cognitive function, Alzheimer’s Disease and Related Dementias (ADRD), and other related outcomes in older age, whether these relationships are mediated by educational and social engagement, and whether LLL would modify the influence of earlier and lifecourse psychosocial exposures. Through a detailed capacity building program, this application will build research and infrastructure capacities to delineate opportunities for dementia prevention in Lebanon and other low-resourced settings.

PI_NAMEs: ELBEJJANI , MARTINE  ;SIBAI, ABLA ;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Adult Children;Age;aged;Aging;aging population;Alzheimer's disease related dementia;American;Arabs;Area;base;biological sex;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Cohort Studies;Collaborations;Communities;Community Participation;Country;Credentialing;Data;Data Collection;Dementia;dementia burden;dementia risk;depressive symptoms;design;Education;Educational Activities;Enrollment;epidemiology study;Evaluation;Exposure to;Financial Hardship;follow-up;Goals;Health;healthy aging;High Prevalence;human old age (65+);improved;Income;Infrastructure;innovation;insight;interest;Investigation;late life;Learning;learning engagement;Lebanon;Life course epidemiology;Life Cycle Stages;life history;life-long learning;Measures;Mediating;men;Methods;middle age;migration;Modeling;older adult;older men;older women;Outcome;Participant;Patient Self-Report;Persons;Pilot Projects;Politics;Population;Populations at Risk;prevent;Prevention;programs;prospective;psychosocial;Psychosocial Influences;public health priorities;Questionnaires;Records;recruit;Recurrence;Registries;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resource-limited setting;Risk Factors;risk mitigation;Risk Reduction;Role;Running;Sampling;sex;social;social capital;social determinants;social engagement;Social Policies;Standardization;stressor;Techniques;Telephone;Universities;Visit;War;Woman;women versus men;Women's prevalence;Work

PROJECT_TITLE: Late Life Learning, Dementia, and Overall Health: An Investigation of The University for Seniors in Beirut.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJRCT NARRATIVE Allergic asthma often starts in early childhood and progresses into adulthood. The central mediator of recurrent disease exacerbation is lung-resident, T helper 2 memory cells. This proposal investigates age-related mechanisms that underlie the establishment of the resident, T helper 2 memory cells in the early lung. The results are expected to identify novel treatment strategies to modulate the progression of allergic asthma from childhood to adulthood.

PI_NAMEs: AI, XINGBIN  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Adoptive Transfer;Adrenergic Agents;Adult;Age;Age of Onset;age related;Airway Disease;airway inflammation;Allergens;Allergic inflammation;allergic response;Alpha Interleukin 2 Receptor;asthmatic;Biological Assay;Birth;Brain-Derived Neurotrophic Factor;Bronchoconstriction;candidate identification;CD4 Positive T Lymphocytes;Cells;Childhood Asthma;chronic inflammatory disease;chronic respiratory disease;Clinical Research;Communication;Complex;Dependovirus;Dopamine;DRD4 gene;early childhood;early life exposure;empowerment;Environment;Epigenetic Process;Extrinsic asthma;Fostering;Gene Delivery;genetic approach;genetic signature;Genetic Transcription;genome wide association study;Histologic;Human;in vivo;infancy;Inflammation;insight;Interleukin-2;Intervention;Life;Link;Location;Long-Term Effects;Lung;lung development;Maps;Mediating;Mediator;Memory;Molecular Target;mouse model;Neonatal;neonatal exposure;neonate;Nerve;Nerve Growth Factors;nerve supply;Neurons;novel;novel therapeutics;Ovalbumin;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Polycomb;postnatal;postnatal development;Predisposition;Publishing;receptor;Recurrence;Recurrent disease;Reporting;Risk;Role;Severities;Signal Transduction;Stat5 protein;T-Lymphocyte;Testing;transcription factor;transcriptomic profiling;transcriptomics;treatment strategy;Viral

PROJECT_TITLE: Age-related mechanisms of T helper 2 memory in the early lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Food insecurity is an important social determinant of aging-related health outcomes. Understanding the impact of food insecurity on cognitive impairment and Alzheimer’s disease and related dementias (ADRD) is of direct relevance to the mission of the NIH, and specifically the NIA. The results of this project will have significant implications for health care providers, public health practitioners, and policymakers to synergistically address food insecurity, improve healthy cognitive aging, and reduce health disparities among older adults.

PI_NAMEs: LEUNG, CINDY  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Affect;African American;aged;Aging;aging related;aging related disease;Alzheimer's disease related dementia;American;Buffers;cardiometabolism;Characteristics;Child;Chronic Disease;Clinical;Cognitive aging;cognitive function;Cohort Studies;Cross-Sectional Studies;Data;Dementia;dementia risk;design;Diagnosis;Diet;Dimensions;Economically Deprived Population;Education;ethnic minority population;evidence base;executive function;Exposure to;Food;Food Assistance Programs;food insecurity;Goals;good diet;Health;Health and Retirement Study;health data;health disparity;Health Personnel;Heterogeneity;Hispanic;Household;human old age (65+);Impaired cognition;improved;Individual;late life;Link;Literature;Long-Term Effects;Low income;Measures;Mediating;Memory;Mental disorders;Mental Health;Minority Groups;Mission;modifiable risk;older adult;Outcome;panel study of income dynamics;Participant;Pattern;physical conditioning;policy implication;Policy Maker;Population;prevent;psychological distress;Public Health;Quality of life;racial minority population;Reduce health disparities;Research;Research Priority;Resources;response;Risk;Risk Factors;Running;Sampling;social determinants;social health determinants;sociodemographics;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;Specific qualifier value;Surveys;Underrepresented Populations;Unhealthy Diet;United States;United States National Institutes of Health;young adult

PROJECT_TITLE: The Longitudinal and Dynamic Effects of Food Insecurity on Cognitive Impairment and Dementia Risk

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The interpretation of new variants, especially those revealed by genetic testing in the clinic, is difficult and hampers the use of genetic information to improve the diagnosis and treatment of disease. To empower variant interpretation, we propose the Center for Actionable Variant Analysis which would measure the effect of ~200,000 single nucleotide variants in ~32 of the most clinically important genes.

PI_NAMEs: FOWLER, DOUGLAS M;STARITA, LEA  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: actionable mutation;Benchmarking;Benign;Biological Assay;Catalogs;Cell Survival;Cells;Classification;Clinic;Clinical;Clinical Data;Code;community empowerment;Consensus;Data;data analysis pipeline;Data Set;data sharing;design;Diagnosis;Disease;Elements;empowerment;Ensure;Genes;genetic information;genetic testing;genetic variant;Genetic Variation;Genome;genome editing;Goals;Human Biology;Human Genetics;improved;Individual;Life;Massive Parallel Sequencing;Measurement;Measures;Metadata;Methods;Modeling;multiplex assay;Nucleotides;Pathogenicity;Patient Care;Phenotype;predictive modeling;Production;protein function;Proteins;Protocols documentation;Reagent;Reproducibility;Resolution;Resources;RNA Splicing;Single Nucleotide Polymorphism;tool;Validation;Variant;variant of unknown significance;web interface;Work

PROJECT_TITLE: The Center for Actionable Variant Analysis; measuring variant function at scale


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Nanotechnology;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: CORVALLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Many conditions with adverse pregnancy outcomes, including ectopic pregnancy, are associated with abnormal placentation. About 1 in 50 pregnancies (~120,000/year) in the US is ectopic, and they account for 4 - 6% of all maternal deaths. In this work, a systemically injected nanoplatform loaded with magnetic nanoparticles will be developed to precisely detect and image placental tissue with MRI and, once within the placenta, generate heat under alternating magnetic field exposure to selectively and non-invasively treat ectopic pregnancy.

PI_NAMEs: TARATULA, OLENA  (contact)

PROGRAM_OFFICER_NAME: CHENG, CLARA M

PROJECT_TERMS: Abnormal placentation;Address;adverse pregnancy outcome;Anatomy;Animal Model;Binding;biocompatible polymer;Biodistribution;Biological Markers;Birth;Blood;Cells;Cessation of life;chemotherapy;Clinic;Clinical;clinically relevant;contrast enhanced;Contrast Media;Data;design;Detection;Diagnosis;Diarrhea;Early Diagnosis;Ectopic Pregnancy;effective therapy;Enzymes;Event;Exposure to;Failure;Fertility;fetal;Fetus;First Pregnancy Trimester;Future;Gadolinium;Gestational Age;Growth;Growth and Development function;Hemorrhage;Human;Human Chorionic Gonadotropin;Hyperthermia;Image;imaging modality;Impairment;implantation;improved;Infant;innovation;Interstitial Pneumonia;Intravenous;intravenous injection;Life;Ligands;Liver;Location;Macaca;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;malformation;Mammalian Oviducts;Maternal Mortality;Measures;Mediating;Medical;Metabolic Clearance Rate;Methotrexate;Modality;Molecular Weight;Mothers;multidisciplinary;Mus;nanomedicine;nanoparticle;nanoparticle delivery;nanopolymer;nanotechnology platform;nature therapy;Nausea;nephrotoxicity;non-invasive imaging;nonhuman primate;noninvasive diagnosis;novel;offspring;Operative Surgical Procedures;Organ;Outcome;Peptides;Placenta;Placenta Diseases;Placental Toxicity;Placentation;Pregnancy;pregnant;prevent;Procedures;Quality of life;Recovery;Research;Research Personnel;Rupture;Safety;Serum;side effect;Signal Transduction;Site;Spontaneous abortion;Syncytiotrophoblast;targeted delivery;Technology;Temperature;Termination of pregnancy;Testing;Therapeutic;Time;Tissues;Toxic effect;Translating;Transvaginal Ultrasound;Treatment Efficacy;trophoblast;Ultrasonography;United States;uptake;Uterine cavity;Uterus;Vascularization;Visualization;Vomiting;Work

PROJECT_TITLE: Nanoparticle-mediated placental imaging and magnetic hyperthermia for management of ectopic pregnancy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Heart Disease;Immunotherapy;Lung;Lung Cancer;Patient Safety;Physical Rehabilitation;Precision Medicine;Prevention;Radiation Oncology;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Radiation therapy, along with surgery, chemotherapy, and immunotherapy, is the gold standard for treating lung cancer. Unfortunately, during radiation treatment of the lungs, the heart can become damaged. In order to decrease the risk of heart damage, this proposed project will focus on establishing a clinical practice guidance model, based on pre-existing cardiovascular risk factors, to help clinicians choose the best type of radiation therapy and the optimal radiation dose for each individual lung cancer patient.

PI_NAMEs: LIAO, ZHONGXING  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: 3-Dimensional;Accounting;Activities of Daily Living;Aftercare;Apoptosis;Biological Markers;Blood;Blood specimen;Brain natriuretic peptide;C-reactive protein;Cancer Patient;cancer survival;cancer therapy;cancer type;Cardiac;Cardiotoxicity;cardiovascular injury;cardiovascular risk factor;Cardiovascular system;Categories;chemoradiation;chemotherapy;Chest;Clinical;clinical practice;clinical risk;cohort;comorbidity;Complication;coronary calcium scoring;Data;Data Set;Decision Making;demographics;Disease;Disease Outcome;DNA Repair;Dose;Event;fitness;Functional disorder;Genes;Genetic;Genetic Predisposition to Disease;Goals;Heart;heart damage;heart function;Heart Injuries;high risk;Immunotherapy;improved;Incidence;Individual;individual patient;Inflammation;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mission;Modality;Modeling;Multivariate Analysis;National Cancer Institute;National Heart, Lung, and Blood Institute;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;Operative Surgical Procedures;optimal treatments;Organ;Outcome;participant enrollment;Patient Outcomes Assessments;patient population;Patient risk;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized risk prediction;Pharmaceutical Preparations;Photons;Physicians;population based;Population Study;predictive modeling;prevent;Probability;Process;prospective;Prospective cohort;Prospective, cohort study;proton therapy;Protons;Radiation;Radiation Dose Unit;radiation risk;Radiation therapy;Randomized;randomized trial;Registries;Reporting;response;Risk;Risk Factors;risk prediction;risk stratification;Selection for Treatments;Shapes;Single Nucleotide Polymorphism;Statistical Models;Structure;Techniques;Testing;Tissues;tool;Toxic effect;treatment planning;trial comparing;Troponin T;tumor;Validation;Vascular calcification

PROJECT_TITLE: Risk prediction and longitudinal assessment of cardiotoxicity and functional capacity trajectory in NSCLC patients

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: After exposure to Mycobacterium tuberculosis (Mtb), the subsequent clinical outcomes vary dramatically, from resistance to infection to severe TB meningitis. We will use genetic, genomic, proteomic, and bioinformatic strategies to examine the full range of this variation during the interaction with Mtb and its human host to discover mechanisms of resistance and susceptibility to infection and disease. Uncovering the genetic differences that underlie heterogenous clinical outcomes will lead to new insights into host-pathogen interactions, novel biomarkers for clinical management, and innovative immunomodulatory treatment strategies.

PI_NAMEs: COX, JEFFERY S;HAWN, THOMAS R (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Area;Bacillus;Bioinformatics;Biological;biomarker discovery;Cells;Clinical;Clinical Management;clinical phenotype;Clinical Treatment;cohort;Data;Data Management Resources;Data Set;Disease;diverse data;experimental study;Exposure to;follow-up;gene product;Genes;Genetic;genetic information;genetic variant;Genetic Variation;genome-wide;Genomics;Heterogeneity;Human;Human Genetics;Immune;Immune system;immunomodulatory therapies;in vivo;Infection;innovation;insight;Integration Host Factors;latent infection;Lung Diseases;Macrophage;Meningeal Tuberculosis;Methods;Modeling;Molecular;mouse model;multidisciplinary;Multiomic Data;Mus;Mycobacterium tuberculosis;novel;novel marker;Outcome;pathogen;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Predisposition;pressure;prevent;Prevention strategy;Process;programs;protein function;Proteins;Proteomics;Pulmonary Tuberculosis;Resistance;resistance mechanism;Resistance to infection;response;Source;synergism;Testing;transcriptome sequencing;transmission process;treatment duration;Treatment Protocols;treatment strategy;Tuberculosis;Uganda;Vaccines;Variant;Vietnam;Work

PROJECT_TITLE: Host Pathogen Variation & TB Pathogenesis


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

PI_NAMEs: HAWN, THOMAS R (contact)

PROJECT_TERMS: Administrator;Communicable Diseases;Communication;Communities;computerized data processing;Creativeness;data management;Educational workshop;Ensure;Evaluation;experience;Faculty;Goals;Grant;Group Meetings;Human Resources;Individual;Leadership;Maintenance;meetings;member;Occupational activity of managing finances;Office of Administrative Management;Operating System;operation;pathogen;Pathogenesis;Procedures;Productivity;programs;Protocols documentation;quality assurance;Quality Control;Research;Research Personnel;Research Project Grants;Resources;Schedule;Scientific Inquiry;Site;Structure;synergism;United States National Institutes of Health;Variant;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE COVID-19 illness is one of the greatest threats to mankind causing substantial mortality, morbidity and huge economic losses, and many suffer from effects of COVID-19 long after the acute infection is resolved. Effective vaccines offer the main path out of this pandemic but breakthrough infections and novel variants evading vaccines and causing severe pathogenesis are major concerns. Common genetic polymorphisms associated with COVID-19 illness and severity can be utilized to identify molecular pathways, genes and cell types driving disease pathogenesis. Our work here will identify functional COVID-19 GWAS variants, provide direct mechanistic insights and help define precise genetic-based severity risk scores in susceptible individuals.

PI_NAMEs: SCHMIEDEL, BENJAMIN JOACHIM (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: acute infection;Affect;Alleles;Anti-viral Response;Automobile Driving;Binding;Biological Assay;breakthrough infection;Candidate Disease Gene;causal variant;cell type;Cells;Clinical;Code;COVID-19;COVID-19 impact;COVID-19 pathogenesis;COVID-19 risk;COVID-19 severity;COVID-19 susceptibility;CRISPR interference;Data Set;Databases;Defect;Disease;disorder risk;DNA Sequence;Economics;Enhancers;epigenomics;Ethnic Origin;exome sequencing;experimental study;Exploratory/Developmental Grant;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Markers;Genetic Polymorphism;Genetic Risk;genome wide association study;genome-wide;genomic locus;Hospitalization;Human;IL10RB gene;Immune;Immune response;Immune system;immunoregulation;Impairment;in vivo;Individual;Inherited;insight;Interferons;Interleukin-10;interleukin-10 receptor;Link;Long COVID;Luciferases;Maps;Mediating;Meta-Analysis;model building;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Natural Killer Cells;novel;oligoadenylate;pandemic disease;Pathogenesis;Pathway interactions;Patients;Population;Predisposition;promoter;Protein Family;Quantitative Trait Loci;Reporter;Reporting;Respiratory Failure;response;Risk;risk variant;Role;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;Symptoms;T-Lymphocyte;Testing;transcription factor;transcriptome;Untranslated RNA;Vaccines;Validation;Variant;viral RNA;Work

PROJECT_TITLE: Experimental identification of functional GWAS variants linked to COVID-19 severity in immune cells

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: DUNSTAN, SARAH JANE (contact)

PROJECT_TERMS: Aftercare;Bacterial Genes;bacterial genetics;Bacterial Genome;bioinformatics tool;candidate identification;Cellular biology;Cessation of life;Cities;Clinical;clinical care;Clinical Data;clinical phenotype;Clinical Research;cohort;Collection;Communities;Data;data resource;Data Set;design;Disease;disease model;Disease Outcome;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Evolution;follow-up;Future;gene discovery;Genes;Genetic;Genetic Determinism;genetic variant;Genetic Variation;genomic data;genomic variation;Genomics;Household;Human;human disease;Immunology;In Vitro;in vivo Model;indexing;Individual;innovation;Investigation;Knowledge;Link;M. tuberculosis genome;Measurement;Medical Genetics;Meningeal Tuberculosis;multidisciplinary;Mutation;Mycobacterium tuberculosis;novel therapeutics;novel vaccines;Observational Study;Outcome;participant enrollment;pathogen;pathogen genomics;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Phenotype;point of care testing;Population;Predisposition;Pulmonary Tuberculosis;Randomized Controlled Clinical Trials;Research;Research Personnel;Resistance;response;Sampling;Signal Transduction;Sputum;System;Technology;tool;transmission process;Treatment Failure;Tuberculosis;Uganda;Vaccines;Variant;Vietnam

PROJECT_TITLE: Genetics & Clinical Cohorts


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE This proposal will use young people as scientific partners to identify nicotine and tobacco- related misinformation on social media. In collaboration with these youth, we will then assess how interacting with this type of misinformation is associated with susceptibility—or being willing to try a nicotine or tobacco product—among youth ages 13-17, particularly Black, Hispanic, and sexual and gender minority (SGM) youth. This information will be used to develop messages to counteract misinformation, and we will assess how acceptable the messages are to young people through surveys and interviews.

PI_NAMEs: SIDANI, JAIME ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Adolescence;Adult;Advertisements;Age;Attitude;Behavior;Black race;Brain;cancer risk;cisgender;Classification;Collaborations;community based participatory research;Cross-Sectional Studies;Data Analyses;Data Analytics;Data Collection;Development;digital;Discrimination;Disparity;disparity elimination;experience;Exposure to;Frequencies;gender minority youth;Goals;health communication;Heterosexuals;High School Student;Hispanic;human centered design;intersectionality;Intervention;Interview;Knowledge;Malignant Neoplasms;Marketing;media use;Methods;Middle School Student;Misinformation;Morbidity - disease rate;mortality;natives;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;Not Hispanic or Latino;Outcome;Pathway Analysis;peer;Persons;Play;Population;Predisposition;prevent;Process;Proliferating;Public Health;Race;recruit;Reporting;Research;research study;Role;Sampling;Sexual and Gender Minorities;sexual minority youth;social media;Social Network;Structural Racism;Surveys;Techniques;theories;Tobacco;Tobacco Industry;tobacco products;Tobacco use;trend;Trust;United States;Voice;Youth

PROJECT_TITLE: Nicotine and Tobacco Misinformation on Youth-Oriented Social Media Platforms


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Prevention

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Environmental exposures can cause the accumulation of reactive oxygen species, which will lead to many diseases such as cancer and neurodegeneration. However, fundamental knowledge on how cells respond to this environmental stress is not fully understood. This proposal aims to carefully study how ubiquitin signaling participates in this oxidative stress response in humans, to promote new methods of mitigating disease progression.

PI_NAMEs: MADUKA, AUSTIN O. (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acute;Address;Air Pollutants;Antibodies;Antioxidants;Apoptosis;Arsenicals;Atherosclerosis;Autophagocytosis;Binding;Biochemical;biological adaptation to stress;candidate identification;Cell Death;Cell Physiology;Cell Survival;Cells;Chronic Kidney Failure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Development;Disease;Disease Progression;Endoplasmic Reticulum;Environmental Exposure;Environmental Risk Factor;Enzymes;Event;experience;exposed human population;Exposure to;Foundations;Genes;Genetic;Genetic Transcription;Genomics;Human;human subject;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Knowledge;Laboratories;Lead;Libraries;loss of function;Malignant Neoplasms;Mammalian Cell;Mediating;Mentors;Methods;Modification;Molecular;multicatalytic endopeptidase complex;Mutation;Necrosis;Nerve Degeneration;novel;Outcome;oxidation;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Physicians;Population;Post-Translational Protein Processing;Postdoctoral Fellow;prevent;Production;protein degradation;Proteins;Proteomics;Reactive Oxygen Species;Recovery;Regulation;Residencies;Residual state;Resistance;response;Ribosomal Proteins;Ribosomes;Role;Scientist;Signal Transduction;skills;Small Interfering RNA;small molecule inhibitor;Stress;Structure;symposium;System;Technology;Testing;tool;Training;Transcriptional Regulation;Translations;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;Ultraviolet Rays;Western Blotting;Work;Yeasts

PROJECT_TITLE: Defining Novel Roles of Ubiquitin Accumulation During the Mammalian Oxidative Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research aims to develop new chemical technologies for efficient preparation of fluorinated molecules, carbonyl compounds, and functionalized carbohydrates. These chemical entities are involved in every aspect of life and can be found in natural products, pharmaceuticals, dyes, pesticides, lubricants, polymers, clothes, and inhaler propellants. The accomplishment of the proposed research will create novel functional molecules to accelerate drug discovery and development, improve the quality of health care products, and promote the establishment of new materials for biomedical applications.

PI_NAMEs: NGAI, MING-YU  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Address;Agrochemicals;Biocompatible Materials;Bioprobe;Carbohydrates;carbonyl compound;Catalysis;catalyst;Chemicals;Complex;Derivation procedure;Development;drug development;drug discovery;Dyes;Goals;health care quality;Hydrocarbons;imaging agent;improved;Inhalators;Life;Lubricants;Natural Products;novel;novel therapeutics;Organic Synthesis;Organometallic Compounds;Oxidation-Reduction;Pesticides;Pharmacologic Substance;Polymers;Preparation;Process;propellant;Reaction;Reagent;Research;Site;sugar;Technology;Therapeutic;Visible Radiation

PROJECT_TITLE: EXCITED-STATE CATALYSIS IN ORGANIC SYNTHESIS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: STEIN, CATHERINE MARIE (contact)

PROJECT_TERMS: Area;Bioinformatics;Biological;clinical phenotype;complex data;Coupled;Data;Data Analyses;data complexity;data integration;Data Set;Databases;Disease;diverse data;experimental study;Gene Targeting;Genes;Genetic;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Human;Individual;innovation;insight;Interdisciplinary Study;Laboratory Organism;Lung;Macrophage;Methods;model organism;Modeling;multiple omics;Mus;Mycobacterium tuberculosis;novel;Overlapping Genes;pathogen;pathogen genome;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Process;Proteins;Proteomics;Research;Research Methodology;Research Priority;Resistance;Signal Transduction;Source;synergism;Systems Biology;Testing;transcriptome;transcriptome sequencing;Tuberculosis;Uganda;Variant;Vietnam

PROJECT_TITLE: Systems Biology, Bioinformatics, & Data Integration


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROGRAM NARRATIVE The Johns Hopkins WRHR program will address the critical shortage of Ob/Gyn-trained researchers by recruiting junior Ob/Gyn faculty who demonstrate strong potential to become productive and independent physician scientists. The JH-WRHR Program leverages the abundant resources of Johns Hopkins University, the growing capabilities and research resources of the Department of Gyn/Ob at Johns Hopkins, and the critically important milieu provided by the national NIH-supported WRHR program. Together, these resources, coupled with a rigorously designed training program, will expand the pool of Ob/Gyn-trained researchers who will advance science of reproductive diseases, gynecologic disorders, obstetrical conditions, and cancers of the reproductive tract to improve the health of women.

PI_NAMEs: SATIN, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Area;Cardiovascular system;career;career development;Caring;Clinical;Clinical Research;Competence;data management;Dedications;Discipline;Discipline of obstetrics;Educational workshop;Ethics;Faculty;faculty support;Funding;Genetic;Goals;Grant;Gynecology;Immunology;innovation;Intervention;Investments;K-Series Research Career Programs;Laboratories;Leadership;medical schools;medical specialties;Mentors;Mentorship;mid-career faculty;Neurosciences;Outcomes Research;Program Development;programs;Public Health;Qualifying;recruit;Research;Research Personnel;Research Training;Resources;Scholarship;Series;skills;success;Teacher Professional Development;Training;Translational Research;Underrepresented Populations;United States National Institutes of Health;Woman;Women's Health;women's reproductive health;Writing

PROJECT_TITLE: Johns Hopkins Women's Reproductive Health Research Career Development Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: COX, JEFFERY S (contact)

PROJECT_TERMS: Alleles;Animal Model;Bacterial Genes;bacterial genetics;Bacterial Proteins;Bioinformatics;Biological Assay;Candidate Disease Gene;causal variant;CBL gene;Cell Wall;Cells;Clinical;cohort;Collaborations;Complement;complex data;CRISPR/Cas technology;Cues;Data;Data Set;Defect;Diagnostic;Disease;Disease Outcome;Distal;diverse data;ELF3 gene;Etiology;Family;Genes;Genetic;Genetic Variation;genome wide association study;Genotype;Goals;Growth;high resolution imaging;Host resistance;Human;Human Genome;Immune;Immune response;in vivo;Individual;Infection;Inflammatory Response;innate immune pathways;Innate Immune Response;insight;Interferon Type I;Laboratories;M. tuberculosis genome;Macrophage;Mediating;Messenger RNA;Modification;mouse model;mutant;Mutation;Mycobacterium tuberculosis;Network-based;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Permeability;Phagosomes;Phenotype;Population;Post-Translational Protein Processing;Predisposition;Prevalence;programs;Protein Secretion;Proteins;Proteomics;Pulmonary Tuberculosis;recruit;repaired;Resistance;response;Scanning;Site;System;Technology;Testing;transcriptomics;transmission process;Tuberculosis;Ubiquitin;ubiquitin ligase;Variant;Vietnam;Vietnamese;Virulence;Work

PROJECT_TITLE: M. tuberculosis strain-dependent interactions with host cells


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Age-related macular degeneration (AMD) is a leading cause of adult-onset blindness and is linked to defects in the blood vessels of the eye. We have discovered that defects in a system (known as the angiopoietin signaling pathway) regulating vessels in the eye cause mice to develop a disease similar to polypoidal choroidal vasculopathy, the commonest form of late-stage “wet” AMD in patients of Asian and African ancestry. In this proposal, we will characterize the role of this system in disease, and test new drug candidates targeting the angiopoietin signaling pathway for treatment of polypoidal choroidal vasculopathy.

PI_NAMEs: THOMSON, BENJAMIN R. (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adult;Affect;African ancestry;Age related macular degeneration;Angiopoietins;ANGPT1 gene;ANGPT2 gene;Animal Model;Asian ancestry;Atrophic;attenuation;Automobile Driving;Biology;Blindness;Blood Vessels;Caliber;cell type;Cells;Characteristics;Chimeric Proteins;Choroid;Choroidal Neovascularization;Clinic;Clinical;Cre driver;Data;Defect;Development;Differentiation Antigens;Disease;disease prognosis;Disease Progression;drug candidate;Drug Targeting;Drusen;Dryness;Endothelial Cells;endothelial dysfunction;Endothelial Growth Factors Receptor;Endothelium;Ethnic Origin;European ancestry;Exhibits;experimental study;Eye;eye blood vessel;Eye diseases;Functional disorder;Future;Genes;Genetic;Genetic Models;Genetic study;Growth Factor;Growth Factor Inhibition;Human;inhibitor;Injectable;insight;KDR gene;Knockout Mice;Lead;Lesion;Link;Maintenance;member;mimetics;Modeling;Morphology;mouse model;Mus;neovascular;Neural Crest;new therapeutic target;NOS3 gene;novel;novel therapeutics;optimal treatments;Pathogenesis;Pathway interactions;Patients;PDGFRB gene;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Photoreceptors;Polyps;Prevalence;prevent;Production;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-akt;Recombinants;recruit;response;Rodent;Rodent Model;Role;Secondary to;Serous;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure of retinal pigment epithelium;System;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Tissues;tool;transcriptomics;Translating;Translations;Variant;vascular bed;Vascular Diseases;Vascular Endothelial Growth Factors;vascular endothelial protein tyrosine phosphatase

PROJECT_TITLE: The role of Angiopoietin-TEK signaling in polypoidal choroidal vasculopathy

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Obesity is a driver of cellular senescence in the brain and may contribute to neurodegenerative diseases such as AD. This project will allow the elucidation of the molecular mechanisms by which senescent cells contribute to neurodegeneration in the context of aging, obesity and AD. This knowledge could potentially lead to novel clinical treatments to counteract AD.

PI_NAMEs: JURK, DIANA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abeta synthesis;Acceleration;age acceleration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Anxiety;anxiety-like behavior;Area;Astrocytes;Attenuated;Brain;brain cell;Brain region;CDKN2A gene;Cell Aging;cell type;Cells;Chronic;Clinical Treatment;Cognitive aging;Data;Dementia;Deposition;Development;diet-induced obesity;Encephalitis;Excision;Fatty acid glycerol esters;Foundations;functional improvement;Genetic;genetic approach;global health;Goals;healthy aging;imaging approach;Imaging Device;Impaired cognition;impaired driving performance;Impairment;Inflammation;innovation;interest;Intervention;Knowledge;Link;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;LOX gene;Mass Spectrum Analysis;Measures;Mediating;Mental Depression;Mental disorders;Microglia;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuroinflammation;Neurons;neuropsychiatric disorder;novel;Obese Mice;Obesity;old mice;oxidation;Parkinson Disease;pharmacologic;Phenotype;Play;Pre-Clinical Model;premature;Process;Reporting;Risk;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;Testing;Tissues;Transgenic Mice;Transgenic Model

PROJECT_TITLE: Does obesity exacerbate age-related cognitive decline via senescence?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE These studies will explore connections between Alzheimer’s disease (AD) and a novel, non-cell autonomous, neuroprotective pathway involving lipid droplet formation in glia due to neuronal stress. The identification of pathways that contribute to AD-onset is likely a key component in the development of a successful therapy. By taking a multidisciplinary approach, our work will define the impact of glial LD formation on disease-risk, onset, and progression while considering the role of genes that are potential therapeutic targets.

PI_NAMEs: BELLEN, HUGO J (contact)

PROJECT_TERMS: Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;American;Amyloid beta-42;Apolipoprotein E;apolipoprotein E-4;Apolipoproteins;ATP binding cassette transporter 1;Attenuated;attenuation;Autopsy;Brain;Cells;cerebral atrophy;Chronic;Coculture Techniques;Data;Defect;Development;Disease;Disease Progression;disorder risk;Drosophila genus;Early Intervention;Endocytosis;Event;extracellular;fly;Future;Genes;genetic risk factor;genome wide association study;Glutamates;Healthcare Systems;Human;human data;hyperphosphorylated tau;Immunohistochemistry;Induced Neurons;insight;interdisciplinary approach;Investigation;Knowledge;Lentivirus;Link;lipid mediator;lipid metabolism;Lipid Peroxidation;Lipids;loss of function;Mammals;Measures;Mediating;Mediator;Microglia;Modeling;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neuroglia;neuron loss;neuronal survival;Neurons;neuroprotection;neurotoxicity;new therapeutic target;novel;Onset of illness;Orthologous Gene;Oxidative Stress;Pathologic;Pathway interactions;Patients;Phosphorylation;Play;premature;Process;Production;Protein Isoforms;Publishing;Rattus;Reactive Oxygen Species;Research;Resolution;response;risk variant;RNA Interference;Role;Running;Severity of illness;short hairpin RNA delivery;Societies;Stress;System;tau aggregation;tau Proteins;Testing;therapeutic target;Time;Tissues;Toxic effect;Up-Regulation;uptake;Variant;Work

PROJECT_TITLE: IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASE

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


PROJECT_TERMS: Address;Adult;Animal Model;antimicrobial;Biological Assay;Candidate Disease Gene;Clinical;Clinical Management;cohort;CRISPR/Cas technology;cytokine;Data;Data Set;detection method;Development;differential expression;Disease;disease heterogeneity;Disease Progression;Dissection;Enrollment;Family;follow-up;gene discovery;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic Transcription;genetic variant;genome wide association study;Genomics;Goals;Heterogeneity;Household;Human;Human Genetics;Immunogenetics;in vivo Model;Individual;induced pluripotent stem cell;insight;Interferons;Interleukin-1 beta;knockout gene;Knowledge;Macrophage;Meningeal Tuberculosis;Methods;Molecular;monocyte;Mus;Mycobacterium tuberculosis;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Pathway interactions;Phosphorylation;Post-Translational Protein Processing;protein protein interaction;Proteins;proteomic signature;Proteomics;Pulmonary Tuberculosis;Regulation;Resistance;resistance mechanism;Resistance to infection;response;risk stratification;Role;Signal Transduction;small molecule inhibitor;Testing;trafficking;transcriptome sequencing;Tuberculosis;Uganda;Vaccines;Variant;Vesicle;Vietnam

PROJECT_TITLE: Human macrophage variation & TB pathogenesis


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_NAME: INTERNATIONAL CANNABINOID RES SOCIETY

PHR: The mission of the International Cannabinoid Research Society (ICRS) is to foster cannabinoid research. Results of research in this area are presented at an annual Symposia on the Cannabinoids. Enhancement of trainee participation in the Symposia, particularly support for individuals traditionally underrepresented in science, and sponsorship of an annual symposium, are the primary goals of the proposed grant.

PI_NAMEs: BRADSHAW, HEATHER BRYTE (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Adolescence;Agonist;anandamide;antagonist;Anxiety;Area;Award;Biology;Books;Brain;Budgets;cannabinoid receptor;Cannabinoids;Cannabis;career;career development;Classification;Clinical Trials;CNR1 gene;CNR2 gene;Collaborations;Communication;Copyright;critical period;Critiques;design;Development;doctoral student;Educational workshop;Endocannabinoids;Epidiolex;ethnic minority;Family suidae;Fostering;Functional disorder;Funding;Funding Agency;Goals;Grant;Health Professional;Homeostasis;Human;improved;Incentives;Individual;interest;International;Investigation;Learning;lectures;Ligands;marijuana use;Medicine;meetings;member;Memory;Mentorship;Mission;Molecular;Motor;Movement;National Institute of Drug Abuse;Neurobiology;neuropsychiatric disorder;next generation;novel;Oral;Participant;Pathology;Physiological;Policy Maker;Postdoctoral Fellow;posters;pre-doctoral;Pregnancy;Printing;Privatization;Process;Program Development;programs;psychologic;Public Health;Publishing;racial minority;receptor function;recruit;Regulation;Reporting;Research;Research Personnel;Rewards;Risk;Science;Scientific Societies;Scientist;Series;Services;Signal Transduction;Social Functioning;Societies;Sports;SR 141716A;Students;success;symposium;Talents;Training;Travel;United States;United States National Institutes of Health;volunteer;Vulnerable Populations;web site;Woman

PROJECT_TITLE: Annual Cannabinoid Research Society Symposium on the Cannabinoids


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Among females, reproductive mood disorders (peripubertal depression, postpartum depression, premenstrual dysphoric disorder, and perimenopausal depression) are prevalent and associated with substantial morbidity and mortality. Reproductive mood disorders are similar to other depressive disorders in symptom expression, but they differ in their greater predictability of affective state change resulting from changing reproductive hormone levels. Training the next generation of researchers in reproductive mood disorders will not only increase our understanding of the causes of these debilitating disorders and aid in the identification of therapeutic targets, but because reproductive mood disorders may serve as a model for studying affective state change, our comprehension of the causes of mood disorders overall will also be advanced.

PI_NAMEs: GIRDLER, SUSAN S. (contact);RUBINOW, DAVID R.

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Postdoctoral Training in Reproductive Mood Disorders


ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Mitotic cell division errors are a major initiating source of DNA damage that can trigger diverse forms of genomic rearrangements. The proposed research will utilize multidisciplinary approaches to investigate the origins of complex genomic alterations from fragmented chromosomes entrapped within aberrant nuclear structures called micronuclei. These studies will provide critical insight into the cellular and molecular mechanisms driving a spectrum of chromosomal abnormalities that underlie a range of human diseases and disorders.

PI_NAMEs: LY, PETER  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Automobile Driving;Bypass;cancer genome;Cell Cycle;Cell division;Cell Nucleus;Cells;Chromosomal Rearrangement;Chromosome abnormality;Chromosome Condensation;chromosome missegregation;Chromosomes;chromothripsis;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytoplasm;daughter cell;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Sequence Alteration;DNA Sequence Rearrangement;Double Strand Break Repair;Encapsulated;Engineering;Environment;Event;Genetic Diseases;Genetic Materials;Genome;genome integrity;genome sequencing;Genomic Instability;Genomics;Human;human disease;Human Genetics;Immune response;Individual;insight;interdisciplinary approach;Interphase;Knowledge;Label;Lateral;Light;Malignant Neoplasms;micronucleus;Microscopy;Mitosis;Mitotic;Molecular;Monitor;Movement;Mutagenesis;Nuclear;Nuclear Structure;Pathway interactions;Phase;Predisposition;premature;programs;Research;response;Shapes;Source;spatiotemporal;Visualization

PROJECT_TITLE: Genomic Instability from Fragmented Chromosomes in Micronuclei

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: URDAHL, KEVIN B (contact)

PROJECT_TERMS: Acceleration;aerosolized;Aerosols;Alveolar Macrophages;Animal Model;Bacillus;Bar Codes;Behavior;Candidate Disease Gene;candidate identification;caseating granulomas;Cell Communication;Clinical;clinical phenotype;cohort;Confocal Microscopy;Containment;data integration;Data Set;Development;Disease;Distant;Dose;Event;Exhibits;experimental study;Gene Expression Profile;Genes;Genetic;Genetic Polymorphism;Goals;Granuloma;Hematogenous;high risk;holistic approach;Human;human disease;human model;Image Analysis;Immune;Immunity;in vivo;Individual;Infection;Inhalation;insight;Intervention;Kinetics;Location;Lung;Lung Diseases;Lung immune response;Lung infections;Macrophage;Mediating;Meningitis;metabolic profile;migration;Modeling;Modification;Molecular;monocyte;mouse model;Mus;mutant;Mycobacterium tuberculosis;neutrophil;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phagosomes;Physiological;Population;pulmonary granuloma;quantitative imaging;response;Shapes;Site;Sorting;Study models;System;Testing;trafficking;transcriptome;transmission process;Tuberculosis;Variant

PROJECT_TITLE: Mtb strain-dependent mechanisms of pathogenesis in mouse models


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE It is estimated that 25.8 million people in the United States (8.3 percent of the population) currently have diabetes, and the rate is higher among the elderly and Hispanics, Native Americans, and African-Americans. The mission of the Penn Diabetes Research Center is to prevent and cure this devastating disease and its complications through interdisciplinary basic and translational research.

PI_NAMEs: LAZAR, MITCHELL A. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Accreditation;Achievement;African American population;Area;base;Basic Science;bench to bedside;Beta Cell;Biological Markers;Biomedical Research;Cardiovascular system;Cellular biology;Chemicals;Clinical;Clinical Sciences;Collaborations;Communication;cost;design;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic Nephropathy;direct application;Direct Costs;Disease;Doctor of Medicine;Doctor of Philosophy;Elderly;Emerging Technologies;Endocrine System Diseases;Endocrinology;Environment;Faculty;Feedback;Fellowship;Fostering;functional genomics;Funding;genome editing;Goals;Grant;Hispanic Populations;Hormones;human tissue;improved;Infrastructure;innovation;Institution;insulin signaling;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;interest;Internet;Investigation;Islet Cell;Islets of Langerhans;Joints;Knowledge;medical schools;member;Mentors;Metabolic Diseases;metabolic phenotype;Metabolism;metabolomics;Mission;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;organizational structure;Pathology;Pennsylvania;Persons;Phenotype;Philadelphia;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;Prevention approach;Productivity;programs;Radioimmunoassay;Recording of previous events;recruit;Research;Research Personnel;Research Support;Research Training;Rodent;Schools;Science;Services;Special Event;success;symposium;The Wistar Institute;Thinking;Training;Transgenic Mice;Translational Research;translational research program;Translations;undergraduate student;United States;Universities;University adminstration;Viral Vector;web site;Work

PROJECT_TITLE: University of Pennsylvania Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Accreditation;Awareness;base;Clinical;clinical investigation;Collaborations;collaborative environment;Communication;Communities;Development;Diabetes Mellitus;Endocrinology;Ethics;Event;Feedback;Fellowship;Fostering;Funding;Goals;Grant;improved;International;Leadership;lectures;Medical Students;member;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;organizational structure;Pennsylvania;Philadelphia;pre-doctoral;prevent;Prevention approach;Productivity;programs;Public Domains;Research;Research Personnel;Resources;Review Committee;Science;Services;synergism;Training;translational research program;translational scientist;Universities;Vision;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative The objective of this proposal is to develop human age-relevant glial cellular models using direct reprogramming technology, in order to recapitulate age-associated phenotypes in brain aging and neurodegeneration and uncover novel underlying mechanisms. We propose to establish cellular models for brain aging and AD using astrocytes directly reprogrammed from fibroblasts of aged subjects and LOAD patients and co-cultures of astrocytes with other brain cell types. The proposed studies will likely help to define roles of glial cellular aging in brain functional deterioration during aging and uncover the underlying mechanisms, which could lead to the development of novel strategies to maintain brain health and reduce risk for AD.

PI_NAMEs: SHI, YANHONG  (contact)

PROJECT_TERMS: Activities of Daily Living;Age;age related;age related neurodegeneration;age-related disease;aged;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Animal Model;Astrocytes;Brain;brain cell;brain health;Cell Aging;Cell Communication;Cell Lineage;Cell model;Cell Reprogramming;cell type;Cells;Cessation of life;Coculture Techniques;cognitive capacity;Complement;design;Deterioration;Development;disability;Disease;disease model;effective therapy;Elements;Epigenetic Process;Fibroblasts;Gene Expression Profile;Generations;hallmarks of aging;Heterogeneity;Homeostasis;Human;human disease;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;Knowledge;Late Onset Alzheimer Disease;Late-Onset Disorder;Learning;Memory;Microglia;Modeling;Modification;Morphology;mouse model;Mus;myelination;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;neuroinflammation;Neurons;novel;novel strategies;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;Organ;Organoids;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Physiology;Play;Process;Property;Reporting;Research;Risk Factors;Risk Reduction;Role;Signal Pathway;single-cell RNA sequencing;Somatic Cell;Source;species difference;stem cells;Synapses;synaptogenesis;Technology;Transgenic Mice

PROJECT_TITLE: Develop age-relevant glial cellular models using human directly reprogrammed cells


PI_NAMEs: KAESTNER, KLAUS H (contact)

PROJECT_TERMS: Adipocytes;Adoption;Applications Grants;ATAC-seq;Basic Science;Bioinformatics;biological systems;Cell Nucleus;Cells;Cellular biology;ChIP-seq;Clinical Research;Communities;Complementary DNA;cost;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;data integration;data repository;Data Set;data submission;data visualization;Diabetes Mellitus;DNA;DNA Resequencing;DNA sequencing;epigenetic regulation;exome;exome sequencing;experience;Experimental Designs;experimental study;Fees;flexibility;functional genomics;Funding;Genes;Genome;genome browser;genomic data;Genomics;global run on sequencing;Goals;Grant;High-Throughput Nucleotide Sequencing;Human;Individual;interest;Islet Cell;Islets of Langerhans;Libraries;Maps;Measures;member;Metabolic;Metabolism;methylome;MicroRNAs;multiple data sources;multiple datasets;multiple omics;Mus;next generation sequencing;novel sequencing technology;Nucleosomes;Pennsylvania;Phenotype;Physiology;Preparation;Protocols documentation;Publications;Quality Control;Reporting;Research;Research Personnel;response;RNA;RNA amplification;Rodent;Sampling;Services;single cell ATAC-seq;single-cell RNA sequencing;Source;System;Technical Expertise;Technology;Training;transcriptome sequencing;Transgenic Mice;Translational Research;Universities;user-friendly;web interface;whole genome;Zebrafish

PROJECT_TITLE: Functional Genomics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Heart Disease;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening. A critical gap exists in our knowledge of the most effective method of delivering cascade screening. This study will compare contact by trained professionals versus the traditional, proband-initiated contact of relatives on the uptake of screening as well as the acceptability of the approaches by both probands and family members.

PI_NAMEs: BEITELSHEES, AMBER L (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: actionable mutation;Address;Affect;Amish;Anxiety;arm;Arrhythmia;autosome;cascade genetic testing;Centers for Disease Control and Prevention (U.S.);Communication;Communities;community engaged intervention;community engagement;comparative efficacy;comparison group;Consolidated Framework for Implementation Research;cost;Coupled;Decision Making;design;Disease;disease-causing mutation;efficacy evaluation;Equity;Ethics;Familial Hypercholesterolemia;Family;Family member;First Degree Relative;Founder Effect;Founder Generation;Frequencies;Genetic;genetic information;Genomic medicine;Genomics;geographic barrier;Goals;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation science;improved;insight;interest;Intervention;Knowledge;Laws;Long QT Syndrome;Malignant Neoplasms;Mental Depression;Methods;Minority Groups;Modeling;Morbidity - disease rate;mortality;National Cancer Institute;Outcome;outreach;Participant;Pathogenicity;Patient Self-Report;Patient-Focused Outcomes;Patients;pilot test;Population;population health;pressure;primary care provider;Privacy;proband;Procedures;process evaluation;Provider;randomized controlled design;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Relative Risks;Research;Resource-limited setting;Risk;Rural;Rural Population;screening;skills;Social Impacts;stem;Sudden Death;Target Populations;Testing;Training;trial comparing;Underserved Population;uptake;Variant;Work

PROJECT_TITLE: Comparing Direct and Indirect Methods for Cascade Screening in Familial Hypercholesterolemia (FH) and Long QT Syndrome (LQTS)


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE The diversity, population size, and health challenges of metropolitan Houston provides an ideal setting for a NIMHD Research Centers in Minority Institutions (RCMI). The University of Houston (UH) proposes to establish the Helping Everyone Achieve a LifeTime of Health (HEALTH) Center for Addictions Research and Cancer Prevention to advance institutional infrastructure to pursue cutting-edge health-equity science. Investing in health-equity science has the potential to save lives and improve the overall quality and length of life for some of our most vulnerable populations.

PI_NAMEs: BEECH, BETTINA M. (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Acceleration;addiction;Address;Administrator;Area;Asian;Asian Americans;Biometry;Black race;cancer prevention;career;Chronic Disease;Collaborations;college;Communicable Diseases;Communities;community advisory board;community engaged research;community engagement;community research;Competence;cost effective;Data;data management;Degree program;design;Development;Diagnosis;Disparity;Early Diagnosis;Educational Materials;Educational workshop;Equity;Ethics;ethnic diversity;Formulation;Funding;Grant;Health;Health Disparities Research;health disparity;health equity;Health Sciences;Hispanic-serving Institution;improved;Infrastructure;innovation;Institution;Intervention;Investments;Laboratories;Latinx;lectures;Location;Longevity;Malignant Neoplasms;marginalized community;member;Mentors;metropolitan;minority health;minority health disparity;Minority Health Research;Minority-Serving Institution;Mission;National Institute on Minority Health and Health Disparities;Native Americans;novel;Outcome;Pacific Island Americans;Paper;Peer Review;Policies;Population Sizes;Postdoctoral Fellow;prevent;Prevention;Prevention strategy;Process;Productivity;professor;programs;Public Health;Public Health Informatics;Publications;Research;research faculty;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;Scientist;Secure;Self Efficacy;Series;Services;success;Support Groups;Techniques;Technology Transfer;Training;Trust;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;vulnerable community;Vulnerable Populations

PROJECT_TITLE: HEALTH Center for Addictions Research and Cancer Prevention


PI_NAMEs: STOFFERS, DORIS A (contact)

PROJECT_TERMS: Affect;Alpha Cell;Animal Model;Area;Basic Science;Beta Cell;Biochemistry;Bioenergetics;Biological Assay;Biophysics;blood glucose regulation;Cell Count;Cell membrane;Cell Physiology;Cells;Cellular biology;Clinical Research;Collaborations;Complex;Computer software;Consultations;Coupled;Diabetes Mellitus;Disease;Electrodes;Electrophysiology (science);Environment;Equipment;equipment acquisition;Experimental Designs;experimental study;extracellular;fluorescence imaging;Fostering;Funding;Gastric Bypass;Genus Hippocampus;Goals;graduate student;Growth;High-Throughput Nucleotide Sequencing;Human;Hyperinsulinism;in vivo;Incubated;insight;Instruction;interest;Investigation;Ion Channel;islet;Islet Cell;Islets of Langerhans;Laboratories;Measurement;member;Metabolic;metabolic phenotype;Methods;Mitochondria;Modeling;Mus;Organ;Oxidative Phosphorylation;Oxygen Consumption;pancreatic islet function;Pathology;Pennsylvania;Performance;Perfusion;Phenotype;phosphorescence;Physiological;Physiology;Play;Postdoctoral Fellow;quantitative imaging;Research;Research Personnel;Resources;Respiration;Rodent;Role;Services;Signal Transduction;Source;Spirometry;success;Techniques;Technology;Tissues;Training;translational therapeutics;Universities

PROJECT_TITLE: Islet Cell Biology Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Diabetes;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This study is designed to investigate the status and longitudinal trajectories of maternal metabolic health and endocrine function for up to five years following pregnancy among women participating in the Puerto Rico PROTECT cohort study. Little is known about the health status of women after the postpartum period and until mid-life, despite emerging evidence that this life stage may be influential with respect to long-term metabolic health outcomes. This study will fill this knowledge gap among a population at high risk for both adverse metabolic health and exposure to environmental chemicals.

PI_NAMEs: KARVONEN-GUTIERREZ, CARRIE ANNE;MEEKER, JOHN D. (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: adverse pregnancy outcome;Aromatic Polycyclic Hydrocarbons;Biological Markers;Blood;Blood Glucose;blood lipid;Blood Pressure;Body Composition;Body Size;Breast Feeding;chemical association;Chemicals;Child Development;Child Health;clinical diagnosis;cohort;Cohort Studies;Data;Data Collection;Data Set;design;diabetes risk;Education;Endocrine;Endocrine disruption;Endocrinology;environmental chemical;Environmental Exposure;Environmental Impact;Estradiol;Estrogens;experience;exposed human population;Exposure to;Fetal Growth;Follicle Stimulating Hormone;follow up assessment;follow-up;Gestational Diabetes;Glucose;Glycosylated hemoglobin A;Hand Strength;Health;Health behavior;health determinants;health of the mother;health record;Health Status;high risk;Hormonal;Hormones;Income;Individual;Influentials;Insulin;Knowledge;LDL Cholesterol Lipoproteins;Life;Life Experience;Lipids;lipoprotein cholesterol;Longterm Follow-up;Maternal Exposure;Maternal Health;Measures;Menopause;Mental Depression;Metabolic;Metabolic Marker;Metals;middle age;Modification;Morbidity - disease rate;Mothers;mullerian-inhibiting hormone;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcome Study;Parabens;Participant;Pattern;Phenols;phthalates;Physical activity;pollutant;Polycystic Ovary Syndrome;Population;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Premature Birth;Puerto Rico;Questionnaires;Recording of previous events;recruit;Research;Risk Factors;sample collection;Sampling;Sex Hormone-Binding Globulin;social determinants;social factors;Social support;sociodemographics;Socioeconomic Status;Stress;Testosterone;Time;urinary;Urine;Visit;Woman;Women Status;Women's Health;Work

PROJECT_TITLE: Pregnancy Exposures to Chemical Mixtures and Later Metabolic Health and Endocrine Function Among Women in the Puerto Rico PROTECT Cohort


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: OBASI, EZEMENARI M (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Affect;Area;Asian Americans;Basic Science;Black race;Budgets;Businesses;cancer prevention;career;Certification;Characteristics;Charge;Chronic Disease;Cities;Collaborations;college;Communicable Diseases;Communication;Communities;Data;Education;Ensure;Environment;Equity;ethnic diversity;Evaluation;evidence base;executive function;Extramural Activities;Funding;Goals;Grant;Health;health disparity;health equity;Health equity research;Health Occupations;Hispanic-serving Institution;Human Resources;improved;Influentials;Infrastructure;innovation;Institution;interest;Investments;Lead;Leadership;Logic;Longevity;member;Mentors;metropolitan;minority scientist;Minority-Serving Institution;Mission;Modeling;Monitor;National Institute on Minority Health and Health Disparities;Native Americans;Operations Research;Pacific Island Americans;Pilot Projects;Policy Maker;population health;Postdoctoral Fellow;prevent;Prevention Research;Productivity;professor;Program Evaluation;programs;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Schedule;Science;Scientist;Strategic Planning;Structure;success;System;Time;Translations;Underrepresented Minority;underserved community;Universities;vulnerable community;ward

PROJECT_TITLE: RCMI Administrative Core


PI_NAMEs: RICKELS, MICHAEL R (contact)

PROJECT_TERMS: Address;Alpha Cell;Animals;assay development;base;Beta Cell;Biochemistry;Biological Assay;Biological Markers;Blood;Cell Physiology;Cellular biology;Center for Translational Science Activities;Chronic Kidney Insufficiency;Clinical;Cohort Studies;Collaborations;Communities;Core Facility;cost;Custom;cytokine;Data;data quality;Development;Diabetes Mellitus;Enzyme-Linked Immunosorbent Assay;Equipment;experience;experimental study;Floor;Fostering;functional genomics;Future;Generations;Glucagon;Glucose Clamp;High Pressure Liquid Chromatography;Home;Hormones;Human;Human Resources;Immunoassay;improved;Inflammation;informatics infrastructure;instrument;islet;Islet Cell;Laboratories;Lipids;Location;Maintenance;Mass Fragmentography;mathematical model;medical schools;member;Metabolic;metabolic phenotype;Metabolism;Microfluidics;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;operation;outreach;Pennsylvania;Performance;physiologic model;Physiological;Procedures;Process;programs;quality assurance;Quality Control;Radioimmunoassay;Research;Research Personnel;Resource Sharing;Resources;response;Rodent;saliva sample;Sampling;Savings;Scientist;service delivery;Services;stable isotope;System;Technical Expertise;Technology;Tissue Sample;Tracer;United States National Institutes of Health;Universities;Urine

PROJECT_TITLE: Radioimmunoassay and Biomarkers Core


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

PI_NAMEs: MERCHANT, FATIMA AZIZ (contact)

PROJECT_TERMS: Acceleration;addiction;Area;behavioral health;Biometry;cancer prevention;Collaborations;college;Communities;Complex;cost;cost effective;Data;data management;Discipline;Disparity;Electronics;Endowment;Environment;Ethics;ethnic diversity;experience;Faculty;Funding;Gifts;Health;Health Disparities Research;health disparity populations;health equity;Health Sciences;Health Services;Incubators;Individual;Infrastructure;innovation;integrated care;Investments;Laboratories;Leadership;Link;marginalized community;Marketing;metropolitan;Mission;Monitor;Names;National Center for Advancing Translational Sciences;National Institute on Minority Health and Health Disparities;novel;Output;Physical therapy;Postdoctoral Fellow;Prevention Research;Primary Care;Productivity;Public Health Informatics;Publications;Recovery;Reproducibility;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;responsible research conduct;satisfaction;Scanning;Science;Scientist;service utilization;Services;System;Techniques;Technology;Time;Trust;underserved community;Underserved Population;United States National Institutes of Health;Universities;user-friendly;Vision;Work

PROJECT_TITLE: RCMI Research Infrastructure Core


PI_NAMEs: EPSTEIN, DOUGLAS J (contact)

PROJECT_TERMS: Address;Animal Model;Applications Grants;blastocyst;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Complement;computerized;conditioning;Consultations;cost;cost effective;CRISPR/Cas technology;Cryopreservation;Derivation procedure;design;Development;developmental genetics;Diabetes Mellitus;Diabetic mouse;Disease;disease model;DNA;Doctor of Philosophy;Electroporation;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;Equipment;Equipment and supply inventories;Etiology;experience;Experimental Models;Fertility;Fertilization in Vitro;Funding;gene function;Gene Modified;Generations;Genes;Genetic;Genome;genome editing;Goals;Grant;Harvest;Herpes zoster disease;Hormonal;improved;In Vitro;Infrastructure;Injections;Institution;Intracytoplasmic Sperm Injections;Joints;Knock-in Mouse;Knock-out;Laboratories;Laboratory Research;Lasers;Maintenance;male fertility;medical schools;member;Metabolic Diseases;Metabolism;Methods;Microinjections;Microsurgery;model development;Modeling;Modification;Monitor;mouse genome;mouse model;Mus;novel therapeutic intervention;Obesity;Oocytes;Organ;Pathogenesis;Pennsylvania;preservation;Principal Investigator;Procedures;professor;Publications;Reagent;Research;Research Personnel;Resources;RNA;Role;Sampling;Services;Speed;sperm cryopreservation;Surveys;System;Technology;therapeutic development;Time;Training;Training and Education;Transgenic Mice;Transgenic Organisms;Universities;Wait Time

PROJECT_TITLE: Transgenic Mouse Genome Editing Core


NIH_SPENDING_CATS: Genetics

PHR: This proposal describes the elucidation of how DNA damage is formed, what the consequences of damage are, and provide the inspiration for the design of agents that are useful tools. DNA damage is associated with the etiology and treatment of disease, such as cancer. Revealing the molecular basis for such diseases and their treatments is facilitated by understanding the underlying chemistry, and impacts human health.

PI_NAMEs: GREENBERG, MARC M (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;adjudication;Biochemical;Biochemistry;Biotechnology;Breathing;Carbon;Cations;Cells;Cellular biology;Chemistry;design;Disease;DNA;DNA Alkylation;DNA Damage;DNA-protein crosslink;Enzyme Inhibitor Drugs;Etiology;experimental study;halogenation;Health;histone modification;Histones;Human;Hydrogen;interest;Investigation;Ionizing radiation;Lesion;Lysine;Malignant Neoplasms;migration;Minor Groove;Modification;Molecular;Molecular Biology;Nitrogen;novel;Nucleic Acids;Nucleosome Core Particle;Nucleosomes;Organic Chemistry;oxidative damage;Pathway interactions;Prevalence;programs;Proteins;Purines;Radiation-Sensitizing Agents;Research;Research Project Grants;Signal Transduction;Site;Structure;Testing;tool;Tube

PROJECT_TITLE: How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: NESIC-TAYLOR, OLIVERA  (contact)

PROJECT_TERMS: Acceleration;addiction;Address;Adopted;Applications Grants;Award;Budgets;Cancer Center;cancer prevention;career;college;Communication;Communities;community engagement;community research;Complex;Creativeness;Data;Development;Disparity;Ensure;Evaluation;experience;Extramural Activities;Feedback;Fostering;Funding;Funding Mechanisms;Generations;Goals;Grant;Health;health disparity;health disparity populations;health equity;Health equity research;health outcome disparity;Health Sciences;Incubators;innovation;interdisciplinary collaboration;Investments;Leadership;marginalized community;Medical center;Medicine;Mentors;Mentorship;metropolitan;minority health;minority health disparity;Minority-Serving Institution;Mission;Monitor;National Institute on Minority Health and Health Disparities;next generation;Outcome;Pathway interactions;Pilot Projects;Postdoctoral Fellow;Process;professor;programs;Public Health;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Support;Resources;Science;Scientist;Secure;Shapes;success;Texas;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;Work;Workforce Development

PROJECT_TITLE: RCMI Investigator Development Core


PI_NAMEs: RABINOWITZ, JOSHUA D (contact)

PROJECT_TERMS: Acceleration;amino acid metabolism;Analytical Chemistry;Animal Model;Cell Culture Techniques;Cells;Cellular Metabolic Process;Chromatography;Clinical;clinical investigation;Clinical Research;cofactor;Consumption;Data Analyses;data quality;Detection;Diabetes Mellitus;Diagnosis;Disease;Etiology;Experimental Designs;Fatty acid glycerol esters;Foundations;frontier;Gluconeogenesis;glucose production;Glycogen;Glycolysis;Goals;Image;improved;in vivo;Infrastructure;Infusion procedures;instrument;Investments;Isomerism;Isotope Labeling;Isotopes;Journals;Label;lipidome;lipidomics;Lipids;liquid chromatography mass spectrometry;Liver;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;member;Metabolic;Metabolic Diseases;Metabolism;metabolome;metabolomics;Methodology;Methods;Modernization;mouse model;Names;Nature;next generation;Niacinamide;Obesity;Pathway interactions;Pattern;Pennsylvania;preclinical study;Preparation;Process;Production;Protocols documentation;Publications;Radioactive Tracers;Reproducibility;Research;Research Design;Research Personnel;Resolution;Sampling;Scanning;Science;selected ion monitoring;Slice;Specificity;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;synergism;System;Time;Tissues;Tracer;Universities;Water

PROJECT_TITLE: Regional Metabolomics and Fluxomics Core at Princeton


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed study will examine the relationship between discrimination, stigma, medical mistrust, health care utilization and health outcomes among homeless older adults in a novel, longitudinal cohort study. Older adults experiencing homelessness may be more likely to experience stigma and discrimination based on various characteristics common in this population (e.g., homelessness, being ethnic/racial minorities, and experiencing substance use disorder and mental health problems) which, in turn, has been linked to medical mistrust. This study will fill the gap in knowledge about medical mistrust as a barrier to health care utilization in older homeless adults and provide a toolkit for practitioners to build trust in health care systems and providers.

PI_NAMEs: KUSHEL, MARGOT B (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adherence;Adult;Age;age acceleration;Aging;barrier to care;Black American;care providers;Caring;Characteristics;Clinic;Clinical;clinical development;cohort;Communication;Communities;community advisory board;COVID-19 pandemic;Criminal Justice;Death Rate;Development;Discrimination;distrust;Elderly;Epidemiologist;Ethnic Origin;Ethnography;experience;follow-up;functional decline;Functional impairment;gender minority group;General Population;Goals;Government;Health;health assessment;health care service utilization;Health Personnel;Health system;Healthcare;Healthcare Systems;high risk population;Homeless persons;Homelessness;Housing;improved;Individual;informant;Institution;Insurance;Intervention;Interview;Interviewer;Knowledge;Lesbian Gay Bisexual Transgender Queer;Link;Longitudinal cohort study;Mediating;Medical;medication compliance;member;Mental Health;Methodology;Methods;middle age;Morbidity - disease rate;mortality;Native Americans;Nature;novel;Nurses;older adult;Outcome;Participant;participant observation;perceived discrimination;Persons;physical conditioning;Physicians;Play;Policies;policy recommendation;poor health outcome;Population;Preventive;Primary Care;primary care visit;Psychologist;Public Health;racial minority;racism;Recommendation;recruit;Research;Research Methodology;Research Personnel;Role;Sampling Studies;Scientist;sexual minority group;Social Environment;Social isolation;social stigma;Social Work;Structure;Substance Use Disorder;Supervision;System;therapy design;Training;Translating;Transportation;trend;Trust;trustworthiness;uptake;Visit;Work;working group

PROJECT_TITLE: Aging Among the Homeless: Social Isolation, Function and Institutional Care

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


PI_NAMEs: SEALE, PATRICK  (contact)

PROJECT_TERMS: Applications Grants;Award;career;Clinical;Clinical Sciences;Collaborations;Communities;Core Facility;cost;Data;Dedications;Development;Diabetes Mellitus;diabetes risk;Discipline;Disease;Environment;Faculty;Feedback;Fostering;Funding;Future;Goals;Grant;high risk;Industry;innovation;Institution;Leadership;Mentors;minority investigator;minority trainee;Mission;new technology;novel strategies;Pennsylvania;Philadelphia;Positioning Attribute;prevent;Process;programs;Research;Research Personnel;Research Project Grants;Schools;Scientist;success;Talents;Techniques;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: REITZEL, LORRAINE R (contact)

PROJECT_TERMS: Achievement;addiction;Address;Advocacy;Affect;American;base;cancer prevention;Clinical;Communication;Communities;community advisory board;community building;community empowerment;community engaged research;community engagement;community engagement process;Community Health;community partners;community partnership;community research;comparative;Country;Coupled;design;Dissemination and Implementation;Education;empowerment;Ensure;Equity;ethnic diversity;evidence base;Failure;Foundations;Generations;Goals;Guidelines;Health;health care service organization;health disparity;health equity;health equity promotion;Health Priorities;Health Promotion;implementation science;improved;informant;Infrastructure;Interactive Systems Framework;interest;Intervention;Investments;Leadership;Maintenance;member;Minority-Serving Institution;Participant;Pathway interactions;Patients;Policy Maker;Population Group;pragmatic implementation;Problem Solving;Process;Program Sustainability;programs;Recommendation;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;research to practice;Scientific Inquiry;Secure;Service provision;Social Justice;Societies;Strategic Planning;System;Translating;Translational Research;Translations;Trust;Underrepresented Populations;underserved community;Universities;Work

PROJECT_TITLE: RCMI Community Engagement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: ZVOLENSKY, MICHAEL J. (contact)

PROJECT_TERMS: Abstinence;Acculturation;addiction;Address;Adult;African American;African American population;American;Anxiety;anxiety sensitivity;anxiety symptoms;Asthma;Behavior;Biological;bodily sensation;cancer prevention;Cardiovascular Diseases;Caring;Cellular Phone;Characteristics;Cigarette;cigarette smoking;comorbidity;coping;COVID-19 stress;craving;Data;Death Rate;depressive symptoms;design;Development;Diagnostic;Diagnostic Factor;disability;Discrimination;Distress;Ecological momentary assessment;Economic Burden;Emotional disorder;emotional symptom;Enrollment;ethnic discrimination;ethnic identity;European;Evaluation;experience;Exposure to;Feedback;follow up assessment;Friends;Health;health disparity;health disparity populations;Improve Access;improved;interest;Intervention;intervention effect;Interview;Latinx;Maintenance;Malignant Neoplasms;Menthol;Methods;mobile computing;Mobile Health Application;National Cancer Institute;negative mood;nicotine replacement;Nicotine Withdrawal;novel;Outcome;Participant;Persons;Phase;pilot test;Prevalence;preventable death;programs;racial discrimination;racism;Randomized;randomized, clinical trials;Recording of previous events;remote delivery;Research;Resources;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking intervention;smoking relapse;Smoking treatment;Societies;Stress;stress symptom;success;Testing;theories;therapy design;Time;Tobacco;Tobacco use;Translating;United States;willingness;Withdrawal Symptom;Work

PROJECT_TITLE: Improving Access to Cigarette Cessation Treatment Among African American Smokers: Development and Evaluation of an Integrated mHealth Application


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Lipoproteins are essential particles that transport fats to different cells in the brain. In individuals with Alzheimer's disease (AD), lipoproteins are not taken up by cells properly and instead bind to other factors outside the cell such as amyloid, leading to amyloid plaque formation, and damage to brain tissue and function. In this proposal, we aim to enhance the activity of the enzyme lipoprotein lipase (LPL), which can help specialized cells called microglia remove excess lipoproteins, prevent amyloid accumulation, and protect against the development of AD.

PI_NAMEs: BRUCE, KIMBERLEY D (contact)

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's neuropathogenesis;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Automobile Driving;Binding;Biology;Brain;brain tissue;Cells;Clinical;Data;design;Development;Disease;Disease Outcome;Disease Progression;Disease susceptibility;effective therapy;Endocytosis;enzyme activity;Enzymes;epidemiology study;Fatty acid glycerol esters;Functional disorder;gain of function;Gatekeeping;Genetic;genetic risk factor;Human;Hydrolysis;immune function;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Intervention;knock-down;Laboratories;Left;lipid metabolism;lipid transport;lipidomics;Lipids;lipoprotein lipase;lipoprotein lipase activators;Lipoproteins;loss of function;Love;Macrophage;Mediating;Metabolic;metabolic imaging;Metabolism;Microglia;Mus;Myeloid Cells;Neurodegenerative Disorders;neuroinflammation;novel;Onset of illness;particle;Phagocytes;Phagocytosis;pharmacologic;Play;Positioning Attribute;Prevalence;prevent;Process;Protein Isoforms;Publishing;Reporting;Research;Resolution;Role;Scaffolding Protein;Senile Plaques;small molecule;Structure;Supplementation;Testing;Therapeutic;therapeutic target;transcriptomics;uptake;Variant

PROJECT_TITLE: Targeting Microglial Lipoprotein Lipase in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: CORVALLIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because improvements in quantitative trait mapping in model organisms is ultimately expected to increase the ability to associate genotypes with complex disease-related phenotypes in human beings. The proposed work will focus on age-related declines in health and fertility, where improvements in trait mapping will potentiate new horizons for gene therapies. Thus, the proposed research is relevant to the part of NIH’s mission that pertains developing fundamental knowledge that will help to enhance health and lengthen life.

PI_NAMEs: BURKE, MOLLY KATHLEEN (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Age;age related decline;Cells;combat;Complex;Data;Development;Disease;Elderly;Environment;Evolution;Fertility;flexibility;Gene Expression;gene therapy;Generations;Genetic;Genetic Variation;genome sequencing;Genotype;Goals;Health;Human;improved;innovation;insight;interest;Knowledge;Laboratories;late life;Life;Longevity;Maintenance;Maps;Methods;Mission;model organism;Molecular;Morphologic artifacts;Mutation;Natural Selections;Organism;Outcome;personalized medicine;Phenotype;Population;Population Control;pressure;Process;Public Health;reproductive success;Research;Research Personnel;Saccharomyces cerevisiae;Sampling;senescence;System;Techniques;Testing;Time;tool;trait;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Experimental evolution of complex traits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative We propose a five-year, pragmatic randomized controlled trial to compare the effect of a clinic-integrated community health worker (CHW) intervention versus treatment as usual on HIV outcomes and social determinants of health (SDOH) among 300 Black people living with HIV (PLH) who are not virally suppressed (>200 copies/ml). To directly test whether an integrated CHW intervention improves rates of viral load suppression among Black PLH, we will carry out a randomized pragmatic clinical trial of 300 Black PLWH, of whom 150 will receive 12 months of CHW support and a comparisons group of 150 Black PLWH who will continue to receive usual HIV care. To determine potential changes, HIV viral load will be extracted from electronic medical records at baseline, 3 months, 6 months, 9 months, and 12 months; and validated SDOH assessments will be administered at baseline, 6 months, and 12 months.

PI_NAMEs: KENYA, SONJIA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;African American;African American population;African Caribbean;Age;barrier to care;Behavior;black men;Black Populations;Black race;Boston;Caribbean region;Caring;Cessation of life;Clinic;Clinical;clinical care;Communities;Community Health;Community Health Aides;community setting;comparison group;Computerized Medical Record;Continuity of Patient Care;Counseling;County;Data;Disparity;disparity reduction;Emigrations;Enrollment;Exhibits;feasibility research;federal poverty level;Florida;Fostering;Goals;Health;health assessment;health care availability;health determinants;health disparity;Health system;Healthcare;Healthcare Systems;HIV;HIV disparities;HIV risk;Homelessness;Hospitalization;implementation protocol;improved;Individual;Intervention;intervention effect;Knowledge;Lesbian Gay Bisexual Transgender Queer;Long-Term Care;Maps;Medical Records;medication compliance;Minority Groups;Modeling;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Observational Study;Outcome;pandemic disease;Participant;peer support;Perception;Persons;Population;Poverty;Pragmatic clinical trial;psychosocial;Public Health;Public Hospitals;racial discrimination;racial disparity;Randomized;Randomized, Controlled Trials;Research;research study;Research Support;Risk Behaviors;Sampling;Scientific Advances and Accomplishments;Self Care;Self Efficacy;sexual minority;sexual minority group;social;social health determinants;Social support;socioeconomics;stem;Subgroup;System;Testing;Training;treatment adherence;treatment as usual;treatment services;trial design;Unemployment;Universities;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: Integrated Navigation Services for Treatment Adherence, Counseling, and Research (INSTACARE)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative: This training grant encourages individuals who are underrepresented in the sciences to seek research careers in the biomedical research, including Hawaiians and other Pacific Islanders, Filipinos, native Americans Indians and Alaskan natives, African Americans, Hispanics, under-represented Asians (Cambodian, Vietnamese, Laotian), as well as those from disadvantaged backgrounds and disabilities. MARC-Hawaii is a two-year training program designed to provide 10 students per year with the technical, operational and professional skills they need to apply to, be accepted in, and successfully complete PhD and MD/PhD programs at research-intensive Institutions of Higher Education. These underrepresented individuals will bring diversity in backgrounds, life experiences, and ideas to the biomedical workforce.

PI_NAMEs: GERSCHENSON, MARIANA ;RIVERS, RACHEL  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: African American;Age;Asian population;biological research;Biomedical Research;Cambodian;career;CCL7 gene;Communities;Cultural Backgrounds;Cultural Diversity;Data;design;disadvantaged background;Doctor of Philosophy;Economics;Educational process of instructing;Educational workshop;Eligibility Determination;Enrollment;Ethnic Origin;experience;experimental study;Faculty;Filipino;Gender;graduate school;Guamanian;Hawaii;Hawaiian;higher education;Hispanic;Inequity;interest;Invisible disability;Island;Life Experience;meetings;Mentors;Mission;Outcome Measure;Pacific Islander;peer;phrases;primary outcome;programs;recruit;Reproducibility;Research;rural dwellers;Samoan;Scientist;Site;skills;social;STEM field;STEM student;Students;summer research;Training;twelfth grade;undergraduate student;Underrepresented Students;Universities;Vietnamese

PROJECT_TITLE: MARC at University of Hawaii at Manoa

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]