NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: 3-Dimensional;Acceleration;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;Astrocytes;Baltimore;Biological Assay;Biological Markers;Blood specimen;Blood Vessels;Brain;cerebral atrophy;Characteristics;Clinical;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;Collaborations;Darkness;Data;deep learning;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;early detection biomarkers;Enrollment;Evaluation;Extramural Activities;Genetic;genetic risk factor;Glial Fibrillary Acidic Protein;Health;Heterogeneity;Hormonal;Impaired cognition;Impairment;Individual;Individual Differences;Inflammatory;Investigation;Laboratories;Life Style;Light;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Maintenance;Measures;Memory;Metabolic;method development;Mitochondria;MRI Scans;multisensory;Neurobiology;neurofilament;neuroimaging;Neuronal Injury;neuropathology;Neuropsychology;normal aging;novel strategies;older adult;Outcome;Paper;Participant;Pathologic;pathological aging;Pattern;Pennsylvania;Plasma;Positron-Emission Tomography;pre-clinical;programs;protective factors;Proteomics;Publications;Publishing;Research;Research Project Grants;resilience;Risk Factors;Sampling;Scanning;Serial Magnetic Resonance Imaging;Sex Differences;skeletal;sleep pattern;specific biomarkers;Structure;Time;Universities;Visit;Walking;Washington;white matter;Work;β-amyloid burden

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Neuroimaging Predictors of Alzheimer's Disease and Cognitive Decline


ACTIVITY: ZIA

ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: RESNICK, SUSAN  (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Anabolism;analytical tool;Baltimore;Behavior;Behavioral;Biochemical Pathway;Biochemical Reaction;Bioinformatics;Biological;Biological Markers;Biology;biomarker discovery;Biometry;Blood;Blood specimen;Brain;brain tissue;cardiovascular risk factor;Cholesterol;Clinical;clinical development;Cognitive;cohort;Cohort Studies;Combined Modality Therapy;Control Groups;Data Set;Development;Diabetes Mellitus;Discrimination;Disease;Disease Progression;drug repurposing;Drug Targeting;Early Diagnosis;effective therapy;endophenotype;Environment;epidemiologic data;Epidemiology;Exposure to;fatty acid metabolism;Funding;Genes;Genetic;Glucose;Goals;Human;hypercholesterolemia;interest;Intramural Research Program;Japanese;Knowledge;Laboratories;Longitudinal Studies;man;Medicine;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metabolomics;middle age;Molecular;molecular phenotype;Neurosciences;non-genetic;novel;novel marker;Obesity;Older Population;Outcome;Pathogenesis;Pathologic;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacology;Phospholipids;Polyamines;Population;pre-clinical;predictive marker;Prevalence;Proteins;Proteomics;randomized, clinical trials;Reaction;Research;Research Project Grants;Risk;Risk Factors;Secure;Serum;Severities;Symptoms;Testing;Tissue Sample;Translating;translational neuroscience;translational research program;transmethylation;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Understanding mechanisms and seeking novel biomarkers in Alzheimer's disease


NIH_SPENDING_CATS: Aging;Diabetes

PI_NAMEs: EGAN, JOSEPHINE  (contact)

PROJECT_TERMS: Age;Aging;Agonist;Alpha Cell;Anabolism;Animals;Apoptosis;Apoptotic;Beta Cell;Blood Glucose;Cardiovascular Diseases;Cell Count;Cell Line;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Clinical;Compensation;cytokine;Diabetes Mellitus;exenatide;Failure;Functional disorder;GLP-I receptor;glucagon-like peptide 1;Glucokinase;glucose sensor;Hormones;Human;Hyperactivity;Insulin;Insulin Resistance;islet;Islets of Langerhans;Kidney Failure;Maintenance;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pancreas;Phenotype;prevent;Process;Proteins;Research;Research Personnel;Rodent;transcription factor;Work

PROJECT_TITLE: CLINICAL PROJECT:  Aging And The Pancreas


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Heart Disease;Women's Health Research

PI_NAMEs: LAKATTA, EDWARD  (contact)

PROJECT_TERMS: Age;age effect;age group;Aging;Animals;Body Surface Area;Cardiac;Cardiac Output;Cardiovascular Models;Cardiovascular system;Clinical;Collaborations;Data;Diameter;Echocardiography;EFRAC;Female;Gender;Heart Atrium;Heart Diseases;heart function;High Cardiac Output;Human;Italy;Left;Left Ventricular Function;Left Ventricular Mass;Macaca mulatta;male;Maryland;Measures;morphometry;nonhuman primate;Right Ventricular Function;sex;Sex Differences;Stroke Volume;Structure;Two-Dimensional Echocardiography;Ventricular;women versus men;Work

PROJECT_TITLE: An echocardiographic study of age- and sex-dependent differences in cardiac function and morphometry in Non Human Primates


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Agents;Adrenergic Receptor;Adult;Aging;Arrhythmia;Behavior;Biophysical Process;Brain;Calmodulin;calmodulin-dependent protein kinase II;Cardiac pacemaker;Cell Culture Techniques;Cell membrane;Cell Physiology;Cells;Characteristics;Clock protein;Complex;Coupled;Couples;Coupling;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Data Set;Disease;Environment;Exhibits;experimental study;Felis catus;Heart;Heart Atrium;Heart Rate;heart rhythm;high resolution imaging;imaging study;In Vitro;Individual;Inferior;insight;Ion Channel;Ions;Kinetics;Laws;Length;Link;Measures;Membrane;Membrane Potentials;Modeling;models and simulation;molecular clock;molecular scale;Nodal;nodal myocyte;Oryctolagus cuniculus;Pacemakers;Phosphorylation;Principal Component Analysis;Proteins;Publishing;receptor;Regression Analysis;response;Rest;Sarcoplasmic Reticulum;Signal Transduction;simulation;Sinoatrial Node;Site;Structure;Surface;symposium;System;Testing;Time;Tissues;Variant;voltage

PROJECT_TITLE: Coherent beat to beat variability of self-similar Ca2+ and surface membrane's signaling mechanisms determines the spontaneous action potential firing rate and rhythm of cardiac pacemaker cells


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

PROJECT_TERMS: Actins;Address;age related;age related changes;aged;Aging;Alkaline Phosphatase;Alzheimer's Disease;Amyloid Proteins;Amyloidosis;Angiotensin II;animal old age;Animals;Aorta;Area;Arterial Disorder;Arterial Fatty Streak;arterial stiffness;Atherosclerosis;base;Blood Vessels;calcification;calcification inhibitor;Calcium;Calpain;calpastatin;Cardiovascular Diseases;Carotid Arteries;Cartilage;Cd68;Cell Aging;Cell Separation;Cells;cerebrovascular;Cessation of life;Chronic;Collagen;Collagen Fiber;Collagen Receptors;Collagen Type I;Collagen Type II;Crossbreeding;crosslink;Cytoskeleton;Dementia;Deposition;Development;EGF gene;Elastic Fiber;Elderly;Elements;endothelial dysfunction;Exhibits;Experimental Models;Extracellular Matrix;Fibrosis;Foundations;frailty;Friction;GDF15 gene;Genetic Transcription;Growth;Heart failure;Human;human subject;Hypertension;Impaired cognition;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;inhibitor;Integrin alphaVbeta3;Invaded;Investigation;juvenile animal;Length;Link;Macrophage;MADH2 gene;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mechanics;Mediating;medin;Membrane;Messenger RNA;migration;milk fat globule;mineralization;Molecular;Mothers;Necrosis;Nodal;Norway;novel;Osteocalcin;Osteonectin;osteopontin;overexpression;Peptide Hydrolases;Phenotype;Physiological;Play;prevent;Production;Proliferating;Property;protein activation;protein expression;Proteins;Rattus;Regulation;response;Role;senescence;Shoulder;Signal Pathway;Signal Transduction;Signaling Molecule;Smooth Muscle Myocytes;Stroke;System;TGFB1 gene;Therapeutic;therapy design;Thoracic aorta;Time;Tissue Inhibitor of Metalloproteinases;Transforming Growth Factor beta;Translations;Vascular calcification;Vascular Smooth Muscle;Vimentin;Vitronectin

PROJECT_TITLE: Calpain-1 Activity and Central Arterial Aging


NIH_SPENDING_CATS: Aging;Cardiovascular

PROJECT_TERMS: Adverse effects;Age;age related;age related changes;aged;Aging;aging related;Alkaline Phosphatase;Angiotensin II;Animals;Aorta;arterial remodeling;Arteries;Blood Pressure;Bromodeoxyuridine;calcification;Calcium;Cardiovascular Diseases;CCL2 gene;CCR1 gene;CDK4 gene;Cell Cycle;Cell Proliferation;Cell Separation;Cells;Cerebrovascular Disorders;chemokine receptor;Chronic;Collagen;Collagen Type I;Deoxyuridine;Deposition;Disease;Early treatment;EGF gene;Elastic Fiber;Elasticity;Elastin;Elderly;Elements;Exhibits;extracellular;Fluorescence;Gel;gel electrophoresis;Gene Expression;Genetic Transcription;Genotype;Growth;Harvest;Health;healthspan;Human;Hypertension;implantation;In Vitro;in vivo;indexing;Inflammatory;Infusion procedures;Integrins;interest;Invaded;knock-down;Knock-out;Knockout Mice;Life Expectancy;Link;MAPK3 gene;Maps;Matrix Metalloproteinases;Medial;Messenger RNA;milk fat globule;Molecular;monocyte chemoattractant protein 1 receptor;Mothers;Mus;NF-kappa B;nonhuman primate;novel;novel strategies;Nuclear Antigens;osmotic minipump;p65;Pathway Analysis;Phosphorylation;Platelet-Derived Growth Factor beta Receptor;Play;prevent;Proliferating;protein expression;Proteins;Proteome;Proteomics;Rat Protein;Rattus;receptor;Role;Saline;senescence;Signal Transduction;Signaling Molecule;Signaling Protein;Smooth Muscle;Smooth Muscle Myocytes;Stains;TGFB1 gene;Thick;TNF gene;transcription factor;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Age-Associated Changes in Arterial Proteome and Aortic Smooth Muscle Signaling


PROJECT_TERMS: 15 year old;Acetylation;Adult;Age;age effect;age group;age related;Aging;Amyloidosis;animal old age;Annexins;Aorta;Apolipoprotein E;Apolipoproteins C;Apoptosis;Arterial Disorder;Arterial Fatty Streak;arterial remodeling;Atherogenic Diet;Atherosclerosis;atherosclerosis risk;Attenuated;Blood;Blood Coagulation Factor;Blood Pressure;Blood Vessels;calcification;Calmodulin;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;Categories;Cell Death;Cell Nucleus;Cessation of life;Cholesterol;Coagulation Process;Collaborations;Collagen;Common carotid artery;Complement;Complement 1q;Coronary;Cysteine;Cytoskeleton;Deposition;Diagnosis;Diet;dietary control;Dipeptidyl Peptidases;discoidin domain receptor 2;Disease;Drosophila genus;Dynamin;Dyslipidemias;EGF gene;Elastin;Elderly;Environment;Erythrocytes;Event;Exhibits;experimental study;Exposure to;Family;Fatty acid glycerol esters;Fibroblasts;Fibrosis;fly;Functional disorder;Genetic;Glycine;Heart;Heart Contractilities;Heart failure;heart function;hemodynamics;Homologous Gene;Human;Impairment;improved;Inflammation;Inflammatory;Integral Membrane Protein;Investigation;Isocitrate Dehydrogenase;lamin C;Lamin Type A;Lead;life span;Link;Lipids;Lysine;Macaca mulatta;Maintenance;member;Metabolic dysfunction;Microfilaments;milk fat globule;Mitochondria;Molecular;molecular targeted therapies;Monkeys;Morphology;Mus;Mutation;Myelin P0 Protein;myocardial damage;Myocardial dysfunction;Myocardial tissue;Myosin ATPase;NADPH Dehydrogenase;National Institute on Aging;Necrosis;Nicotinamide adenine dinucleotide;nonhuman primate;novel;novel marker;Nuclear;old mice;overexpression;Oxidoreductase;Palmitates;Pathology;periostin;Phenocopy;Phosphorylation;Physiologic pulse;Population;premature;Prevention approach;Prokaryotic Initiation Factor-2;Proteins;Proteome;Proteomics;Rattus;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Resveratrol;Role;S100 Proteins;S100A4 gene;Sampling;Sarcomeres;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Serine Protease;Serum Amyloid P-Component;SIRT1 gene;Sirtuins;Smooth Muscle Myocytes;Soil;stem;Stress;stress tolerance;Therapeutic;Tissue Harvesting;Tissues;TNF gene;transcription factor;transcriptomics;United States National Institutes of Health;Vascular Smooth Muscle;Vinculin;Vitronectin;Voltage-Dependent Anion Channel

PROJECT_TITLE: Effects of Aging on Experimental Atherosclerosis in Nonhuman Primates


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension

PROJECT_TERMS: activation-induced cytidine deaminase;Adenoviruses;age effect;Age Months;age related;Aging;Amyloidosis;Angiotensin II;antagonist;Anti-Inflammatory Agents;Antibodies;Antibody Specificity;Antibody titer measurement;Aorta;Apolipoprotein E;arterial remodeling;arterial stiffness;atherogenesis;Atherosclerosis;Attenuated;Autoantibodies;B-Lymphocytes;Biological Aging;Blood Pressure;c-ets1 transcription factor;calcification;Caloric Restriction;Cardiovascular Diseases;cardiovascular health;CCL2 gene;Cell Aging;Cell Separation;Cells;Cellularity;Cholesterol;Chronic;Circulation;Collagen;Collagen Type I;Complementary DNA;Deceleration;density;Deposition;Disease;EGF gene;Elastic Fiber;Elastin;Elastin Fiber;endothelial dysfunction;Evaluation;Extracellular Matrix;Fibrosis;frailty;Gelatinase A;Gelatinases;Genetic Transcription;Harvest;Health;healthspan;Hypertension;Immunoglobulin G;Immunoglobulin M;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;inhibiting antibody;Inhibition of Matrix Metalloproteinases Pathway;Interstitial Collagenase;intimal medial thickening;Invaded;Length;life span;Link;Losartan;Macrophage;Malondialdehyde;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;medin;Metalloproteases;milk fat globule;MMP2 gene;Molecular;mRNA Expression;Mus;NF-kappa B;nuclear factor-erythroid 2;osmotic minipump;overexpression;oxidized low density lipoprotein;Pathogenicity;Phenotype;Phosphorylation;Plasma;Platelet-Derived Growth Factor;platelet-derived growth factor BB;preservation;pressure;prevent;Production;proendothelin 1;Profibrotic signal;Proliferating;protein expression;Protein Glycosylation;Proteins;Rattus;receptor;response;Serum;Signal Transduction;Signaling Molecule;Smooth Muscle Myocytes;Specificity;TGFB1 gene;Tissues;transcription factor;Translations;Up-Regulation;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;young adult

PROJECT_TITLE: Effect of Metalloprotease Inhibition on Age-Associated Arterial Remodeling


PI_NAMEs: WANG, MINGYI  (contact)

PROJECT_TERMS: Acceleration;Actins;age related;age related changes;Age-associated memory impairment;aged;Aging;aging related;Angiotensin II;Angiotensin II Receptor;animal old age;antagonist;Aorta;Apoptosis;Apoptotic;Atherosclerosis;Attenuated;Blood Pressure;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular system;CC chemokine receptor 2;CCL2 gene;Cell Cycle;Cell Separation;Cells;Cellularity;Chest;Chronic;Collagen;Collagen Type I;Crossbreeding;Cytoskeleton;Deceleration;Dementia;Deposition;Development;discoidin domain receptor 2;Down-Regulation;Elastic Fiber;Elastin;Elderly;Elements;Equilibrium;ETS1 gene;Exhibits;Experimental Models;Extracellular Matrix;Fibroblasts;Fibronectins;Fibrosis;Friction;Gelatinases;Genes;Genetic Transcription;Heart Injuries;Heterogeneity;human model;Hypertension;Impaired cognition;In Situ;In Vitro;in vivo;Individual;Inflammatory;inhibitor;Injury;Integrin alphaVbeta3;Integrins;Interstitial Collagenase;Invaded;juvenile animal;knock-down;Knockout Mice;Length;Link;Losartan;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;mechanical properties;Mechanics;Mediating;Messenger RNA;Metalloproteins;MicroRNAs;MMP2 gene;Molecular;Mothers;Myocardial;Myocardial dysfunction;Myocardium;nonhuman primate;novel;novel strategies;Phenotype;Phosphorylation;Physiological;Play;Predisposition;preservation;pressure;prevent;Prevention;Production;proendothelin 1;Proliferating;Proteins;Rattus;Rattus norvegicus;receptor;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Role;senescence;senescence associated secretory phenotype;Signal Transduction;Signaling Molecule;Small Interfering RNA;Smooth Muscle Myocytes;Stroke;TGFB1 gene;Therapeutic;therapy design;Time;Translations;Tropoelastin;Up-Regulation;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Western Blotting;wound healing

PROJECT_TITLE: Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1  Signaling Loop


PROJECT_TERMS: Activities of Daily Living;Age;Age Months;age related;age related changes;age related decline;age related deterioration;aged;Aging;Attention;Autonomic nervous system;Bioinformatics;Biological Markers;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cell Physiology;cell type;Cells;Cessation of life;Characteristics;cohort;Compensation;Complex;Constitution;Cross-Sectional Studies;Databases;Deterioration;Disease;Elderly;Electrocardiogram;Epidemic;experience;frailty;Frequencies;Functional disorder;gene discovery;Gene Expression Profile;Genes;Genetic Markers;Genetic Transcription;hallmarks of aging;Heart;heart function;Heart Rate;heart rate variability;Human;indexing;Left ventricular structure;Life;life span;Link;Longevity;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Maps;Maximum Heart Rate;Measurement;Measures;MicroRNAs;Minor;Modeling;Molecular;mortality;Mus;Pacemakers;Pathway interactions;Physiological;Population;posttranscriptional;Production;Proxy;Publishing;rate of change;Regulation;respiratory;Rest;Sampling;Series;Sinoatrial Node;Structure;Syndrome;therapeutic target;Time;time interval;transcriptome sequencing;Withdrawal;Work

PROJECT_TITLE: Decreased pacemaker activity in aged sinoatrial node


PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Acceleration;Action Potentials;analog;antagonist;Biological Process;calmodulin-dependent protein kinase II;Cardiac pacemaker;Cell Cycle;Cell Membrane Permeability;Cells;Characteristics;Confocal Microscopy;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Diglycerides;Family;Goals;Heart Hypertrophy;inhibitor;inorganic phosphate;Inositol;Length;Mediating;Muscle Cells;nodal myocyte;NOS1 gene;novel;Oryctolagus cuniculus;Pacemakers;Patch-Clamp Techniques;Pathway interactions;Phosphatidylinositols;Phospholipase C;Phosphorylation;Physiological;Protein Family;Protein Kinase C;Protein Kinase C Inhibitor;Proteins;receptor;Regulation;response;Role;Ryanodine Receptor Calcium Release Channel;Second Messenger Systems;Signal Transduction;Sinoatrial Node;Site;theories;transmission process;Ventricular;Western Blotting;Work

PROJECT_TITLE: EPAC, PKC and CaMKII regulate local Ca2+ releases and cardiac pacemaker firing


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

PROJECT_TERMS: Acids;Age;Alpha Cell;alpha-gustducin;Animals;Behavior;cell type;Cells;Citric Acid;Clinical;Code;Eating;Elderly;Enhancers;Esthesia;Exhibits;Feeding behaviors;Food;Food Preferences;Future;Gastric Emptying;ghrelin;ghrelin receptor;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;GTP-Binding Protein alpha Subunits;Homeostasis;Hormonal;Hormones;Hypersensitivity;improved;In Vitro;in vivo;insulin secretion;Islet Cell;Knockout Mice;L Cells;Mammals;Mediating;Metabolic;Modality;Molecular;Mus;Peptides;Perception;Peripheral;Persons;Physiological;Play;Population;proglucagon;Quality of life;Regulation;Research;response;Role;Satiation;Site;Sodium Chloride;stem cells;Stimulus;Sucrose;sweet receptor;sweet taste perception;Sweetening Agents;Taste Buds;Taste Perception;taste system;Transgenic Mice;Type II Epithelial Receptor Cell;Type III Epithelial Receptor Cell;Wild Type Mouse;Work

PROJECT_TITLE: CLINICAL PROJECT: A study of hormone-expressing taste cells: in vivo and in vitro


NIH_SPENDING_CATS: Aging;Biotechnology;Natural Products

PROJECT_TERMS: Affinity;Affinity Chromatography;Agonist;antagonist;Binding;Binding Proteins;Biological;Biological Assay;Blood capillaries;Botanicals;cellular targeting;Chemicals;Chromatography;Column Chromatography;Complex;Computer Models;Data;Development;Disease;drug discovery;Drug Screening;Drug usage;Fishes;high throughput screening;Immobilization;inhibitor;Ligand Binding;Ligands;magnetic beads;Membrane;Methods;Mitochondria;Modeling;Nicotinic Receptors;novel;novel therapeutics;Nuclear;pharmacologic;Pharmacology Study;pharmacophore;Physical condensation;protein protein interaction;Proteins;receptor;screening;small molecule;small molecule libraries;Solid;Sorting;Surface;System;Techniques;Testing;Time;tobacco screening;Tobacco smoke;Tubular formation

PROJECT_TITLE: Immobilized Proteins In Drug Discovery


NIH_SPENDING_CATS: Aging;Bipolar Disorder;Brain Disorders;Chronic Pain;Depression;Mental Health;Mental Illness;Neurosciences;Orphan Drug;Pain Research;Prevention;Rare Diseases

PROJECT_TERMS: Address;age effect;Aging;Baltimore;Bipolar Depression;Central Nervous System Diseases;Cerebrospinal Fluid;chronic pain;Clinical;clinical effect;Collaborations;Complex Regional Pain Syndromes;Development;Diagnosis;Disease;Dose;drug discovery;drug disposition;Drug Kinetics;drug metabolism;Drug usage;Early identification;high risk;improved;Inflammation;Infusion procedures;Investigation;Ketamine;Laboratories;Longitudinal Studies;Mass Spectrum Analysis;medical schools;Mental Depression;metabolic profile;metabolomics;molecular modeling;mouse model;Muscle;novel;novel therapeutics;pain relief;Patients;Pattern Recognition;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Plants;Plasma;Prevention strategy;Proteomics;Research Personnel;Resistance;response;senolytics;Series;Staging;Synthesis Chemistry;Techniques;Therapeutic;United States National Institutes of Health;Wood material

PROJECT_TITLE: Bioanalysis, Drug Metabolism and New Drug Discovery


PROJECT_TERMS: Age;age acceleration;age effect;Age Months;age related changes;Aging;aging biomarker;aging process;Alzheimer's Disease;Animal Model;Animals;Ants;Atropine;Baltimore;Biological Markers;Blood Vessels;Caloric Restriction;Cardiac;Cardiovascular system;Cessation of life;Clinical;Clinical Research;cohort;Data;Databases;Dementia;Diabetes Mellitus;Echocardiography;efficacy validation;Elderly;Electrocardiogram;Endocrine system;Environment;Equilibrium;Exercise;Food;Gene Expression Profile;Genetic;Goals;Healthcare Systems;healthspan;Heart;Heart failure;Heart Rate;Human;human data;Individual;Intervention;Investigation;Length;life span;Literature;Longitudinal Studies;male;Malignant Neoplasms;Measures;Medical;mouse model;Mus;neural;overexpression;Pathologic;Pattern;Phenotype;Physiological;Population;potential biomarker;pre-clinical;programs;Propranolol;Publishing;quantification of aging;Reporting;Running;Siblings;social;Societies;Speed;Stroke;Study Subject;Surface;Testing;Transgenic Mice;Water

PROJECT_TITLE: Baltimore Longitudinal Study of Mice Aging


PROJECT_TERMS: 3-Dimensional;Action Potentials;Age;age related;Antibodies;Appearance;Arrhythmia;Binding Proteins;Calcium;Cells;Connexin 43;Coupling;Diameter;electric impedance;external ear auricle;extracellular;Extracellular Space;Goals;HCN4 gene;Heart;heart rhythm;Image;Imaging Techniques;immunoreactivity;in vivo;interstitial;interstitial cell;Laser Scanning Confocal Microscopy;meter;Methods;Monitor;Mus;neurotrophic protein S100beta;nodal myocyte;old mice;Pathway interactions;Pattern;Phenotype;Preparation;Proteins;Rest;Sinoatrial Node;Tissue imaging;Tissues;transcription factor;Transmission Electron Microscopy;Vesicle;vesicular release

PROJECT_TITLE: Pacemaker cells meshwork the key player in the intercellular vesicles exchange within heart in young and old mice.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: GREIG, NIGEL H. (contact)

PROJECT_TERMS: 5' Untranslated Regions;Academia;Acetylcholine;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Affect;Aging;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analog;Animal Disease Models;Animal Model;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Astrocytes;Basic Science;behavioral impairment;Biochemical;Biochemistry;Biological;Biological Markers;Brain;Brain Injuries;Brain region;Cell Death;Cell model;Cells;Central Nervous System;Chemical Warfare;Chemistry;cholinergic;Cholinesterase Inhibitors;Cholinesterases;Clinic;Clinical;Clinical assessments;clinical development;Clinical Drug Development;Clinical Investigator;clinical translation;Clinical Trials;clinically relevant;Cognition;Collaborations;controlled release;design;Development;Disease;Disease Marker;Disease Progression;Distant;Dose;Down's Syndrome;drug candidate;Drug Design;drug development;drug discovery;Drug Kinetics;Drug Targeting;early phase clinical trial;Elderly;Elements;Enzyme Inhibitor Drugs;Enzymes;Evaluation;Event;exosome;Extramural Activities;Failure;Formulation;Gatekeeping;Goals;Health;Health Benefit;Human;Impairment;in vivo;in vivo Model;Industry;Inflammation;inhibitor;Investigation;Investigational Therapies;Kinetics;Legal patent;Licensing;Measurement;Mediating;Messenger RNA;Metabolism;Methods;misfolded protein;Molecular;Molecular Target;multidisciplinary;Myasthenia Gravis;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron apoptosis;neuron loss;Neurons;neuroprotection;neuropsychiatry;Neurotransmitters;New Agents;new therapeutic target;novel;novel therapeutics;Oral;Oxazoles;Parkinson Disease;Pathway interactions;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase I Clinical Trials;Phase I/II Clinical Trial;phenserine;Phenylcarbamates;Plasma;Positioning Attribute;posttranscriptional;pre-clinical;Pre-Clinical Model;pressure;Procedures;Process;Production;prophylactic;Protein Precursors;Proteins;reduce symptoms;regenerative;Research;Research Project Grants;Resources;response;Rewards;Risk;Role;Safety;Sampling;Series;Site;Stroke;stroke model;System;tau Proteins;Technology;Testing;Therapeutic;Time;Toxic effect;TP53 gene;transcription factor;Translating;Translational Regulation;Translations;Traumatic Brain Injury;Up-Regulation;X-Ray Crystallography

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity

PROJECT_TERMS: Academia;Acute;Age;age related;Aging;Agonist;Ally;Alzheimer's Disease;Anabolism;analog;Animal Disease Models;Animals;Apoptosis;Appetite Regulation;Basic Science;Beta Cell;Binding;Biochemical;Biological;Brain;Cell Culture Techniques;Cell Proliferation;Cell Transplantation;Cells;Central Nervous System;Chronic;Clinic;Clinical;Clinical assessments;clinical development;Clinical Drug Development;Clinical Trials;Collaborations;COVID-19;Degenerative Disorder;demented;Dementia;design;Development;Diabetes Mellitus;Diet;Dipeptidyl Peptidases;Disease;Disease Progression;drug candidate;Drug Design;drug development;drug repurposing;Drug Targeting;Dyskinetic syndrome;early phase clinical trial;effective therapy;Elderly;Elements;Endocrine;Enzymes;Epidemic;epidemiology study;exenatide;Extramural Activities;Fibromyalgia;Food;Formulation;gastric inhibitory polypeptide receptor;Genetic Predisposition to Disease;Genetic Transcription;GLP-I receptor;Glucagon Receptor;glucagon-like peptide 1;Glucose;Goals;Health Benefit;Human;Huntington Disease;Impairment;in vivo;in vivo Model;Industry;Inflammation;Ingestion;inhibitor;Insulin;insulin secretion;insulin signaling;Investigation;Investigational Therapies;Investments;islet;Korea;Legal patent;Licensing;Life;Link;Metabolism;mimetics;Modeling;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurons;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Oxidative Stress;Pain;Pancreas;Parkinson Disease;Pathogenicity;Peptides;peptidomimetics;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;physical inactivity;Physicians;Plasma;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;Property;Pseudotumor Cerebri;receptor;Reporting;Research;Research Project Grants;Resources;response;Rewards;Risk Factors;Rodent;Role;Satiation;Serine Protease;Stroke;Structure of beta Cell of islet;Testing;Time;Tissues;Translating;Translations;Traumatic Brain Injury;treatment strategy;trend

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  Neuroprotective role of GLP-1 receptor agonists (Neurodegenerative disorders & Alzheimer's disease)


PI_NAMEs: DE CABO, RAFAEL  (contact)

PROJECT_TERMS: Affect;Age;Age Months;age related;age related changes;age related decline;Aging;aging process;Animals;Atlases;Award;Baltimore;behavioral phenotyping;biobank;Bioinformatics;Biological Markers;Biological Process;Blood;Blood Glucose;Body Composition;Body fat;Body Weight;Brain imaging;Breeding;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cell Aging;Cell Communication;Cells;Chronic;cognitive change;cohort;Computing Methodologies;Contracts;Custom;Development;Disease;Echocardiography;Enrollment;Environment;Epigenetic Process;Erythrocytes;Euthanasia;Evaluation;Fasting;fasting glucose;Fatty acid glycerol esters;Feces;Female;food consumption;Formula Diets;Freezing;functional decline;Functional disorder;gait examination;Gait speed;Genomics;Glucose;Hand Strength;healthspan;Human;imaging modality;in vivo;Infiltration;Inflammation;Infrastructure;Insulin;Insulin Resistance;Learning;Life;life span;Longitudinal Studies;male;Maps;Measures;Memory;Metabolic;metabolic phenotype;Metabolism;metabolomics;microCT;model organism;Molecular;morris water maze;mortality risk;Motor Activity;Mus;Muscle;Neuronal Dysfunction;nonhuman primate;OGTT;Onset of illness;Organism;outcome prediction;Periodicals;Phenotype;Physiological;programs;Proteomics;Psyche structure;Research;Same-sex;Sampling;Schedule;senescence;Serum;sex;subcutaneous;System;Temperature;Testing;The Jackson Laboratory;Thinness;Time;Tissues;transcriptomics;treadmill;Urine;Width;Work;X-Ray Computed Tomography

PROJECT_TITLE: Study of Longitudinal Aging in Mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid deposition;amyloid imaging;Baltimore;Binding;Biological Assay;Biological Markers;Cognitive;cognitive change;Collaborations;Data;Deposition;Disease;Failure;Funding;Image;imaging study;Individual;Laboratories;Loneliness;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;Measures;Memory;Memory Loss;Nerve Degeneration;neuroimaging;neuroinflammation;Neuronal Injury;Participant;Personality Character;Plasma;Positron-Emission Tomography;pre-clinical;Publications;Questionnaires;radioligand;Research Project Grants;Sampling;Scanning;Spatial Distribution;Staging;tau Proteins;Universities;Washington

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: PET tau imaging in BLSA and GESTALT as an Early Marker of Alzheimer's Disease


PI_NAMEs: BASISTY, NATHAN  (contact)

PROJECT_TERMS: Adipocytes;age related;age related decline;Aging;aging biomarker;aging population;aging related;biological age;Biological Aging;Biological Markers;biomarker signature;Blood;blood-based biomarker;Cells;circulating biomarkers;Circulation;Clinical;clinical phenotype;cohort;Collection;Coupled;Data Collection;Development;Disease;Elderly;Epithelial Cells;Fibroblasts;frailty;Future;Geroscience;Glucose;Health;Human;Immune;Individual;Inflammation;innovation;Intervention;Intervention Trial;life span;Linear Models;longitudinal human study;Longitudinal Studies;Lymphocyte;machine learning algorithm;Measurement;Measures;Mediating;Metabolic;minimally invasive;Modeling;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;multiple chronic conditions;multiple omics;Mus;Myoblasts;nanoparticle;novel;novel marker;novel strategies;obese person;Obesity;Outcome;outcome prediction;Pathology;Phenotype;Physical activity;Physiological;Plasma;Proteins;Proteome;proteomic signature;Proteomics;quantification of aging;senescence;Senotherapeutic;Serum;Solid;Testing;theories;Tissues;tool;trait;treatment strategy

PROJECT_TITLE: Development of Sensitive and Specific Proteomic Biomarkers of Aging, Health, Frailty, and Morbidity in Human and Mouse Cohorts


PROJECT_TERMS: Adipocytes;Adipose tissue;age related;age-related disease;Aging;aging population;Baltimore;Biological Markers;Biology;Blood;Blood Glucose;Blood Vessels;Body mass index;candidate marker;Cardiac;Cell Culture Techniques;Cell secretion;Cell Separation;Cell surface;cell type;Circulation;Clinical;Cohort Studies;Collaborations;Data;drivers of aging;Excision;experimental study;Fatty acid glycerol esters;Fibroblasts;Flow Cytometry;frailty;High Density Lipoproteins;Hospitals;Human;human tissue;Immunofluorescence Immunologic;improved;in vivo;insight;Institutional Review Boards;Kidney;Longevity;Longitudinal Studies;Low-Density Lipoproteins;Lung;Manuscripts;Metabolic;Methods;Modernization;molecular marker;monocyte;Mus;Musculoskeletal;Neurologic;obese person;Obesity;Older Population;Outcome;Participant;personalized approach;Phenotype;Plasma;Population;Population Heterogeneity;pre-clinical;predictive signature;Preparation;Proteins;Proteome;Proteomics;Resources;Saints;senescence;senescence associated secretory phenotype;senescent cell;Specimen;Spectrometry;subcutaneous;Surface;targeted biomarker;targeted treatment;Technology;Therapeutic;therapy development;Tissues;trait;Translations;Validation;Vascular Endothelial Cell;Work

PROJECT_TITLE: Targeting, Quantifying, and Isolating Heterogeneous Populations of Senescent Cells from Tissues via Cell Surface and Secreted Proteomes


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: age related;age-related disease;Aging;aging related;Autophagocytosis;Biological;Clinic;Collaborations;Communities;Complex;computational platform;Computer software;computerized tools;Data Analyses;Development;Disease;Equilibrium;Fatty acid glycerol esters;Goals;hallmarks of aging;Human;human study;in vivo;Institutional Review Boards;Isotopes;Journals;Label;Manuscripts;Measurement;Measures;Metabolic;Methods;Mitochondria;Modeling;multicatalytic endopeptidase complex;Mus;Muscle;Muscular Atrophy;Nerve Degeneration;Non-Insulin-Dependent Diabetes Mellitus;open source;Pathology;Peripheral Blood Mononuclear Cell;Process;Protein Biosynthesis;protein degradation;Proteins;Proteome;Proteomics;proteostasis loss;Publishing;Research;Role;sarcopenia;Scientist;skeletal muscle wasting;Skin;Software Tools;System;therapeutic target;Time;Tissues;tool;Translations;Ubiquitin;Universities;user-friendly;Washington;Water;Work

PROJECT_TITLE: Proteomic Pipelines for the Quantification of Abundance and Turnover of Post-Translationally Modified Proteins in Aging Studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PI_NAMEs: WALKER, KEENAN  (contact)

PROJECT_TERMS: Acute;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Atherosclerosis Risk in Communities;Baltimore;biobank;Biological Markers;Blood Vessels;Brain;Chronic;Circulation;Clinical;Cognition;Cognitive;cohort;Cohort Studies;Data;Dementia;dementia risk;differential expression;Disease Progression;endophenotype;Epidemiologic Methods;Exposure to;Goals;Herpesviridae;Human;Immune;Infection;Inflammatory;Longitudinal cohort study;Longitudinal Studies;Measures;Memory;Nerve Degeneration;neuroimaging;older adult;Proteins;Proteomics;Research Project Grants;Risk;Structure;systemic inflammatory response;vascular risk factor;Women's Health;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Understanding immune/inflammatory and vascular mechanisms in brain aging and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Alzheimer's Disease;Amyloid beta-Protein;Atherosclerosis Risk in Communities;Baltimore;Biological;Biological Process;Brain;brain health;brain magnetic resonance imaging;brain volume;burden of illness;Central Nervous System;Cerebral small vessel disease;Cognitive;cognitive testing;cohort;Data;Dementia;differential expression;experience;Funding;Future;Goals;Immune;Impaired cognition;Individual;Longitudinal cohort study;Longitudinal Studies;Measurement;Measures;Methods;neuroimaging;Participant;Pathway interactions;Peripheral;Plasma;Plasma Proteins;Positron-Emission Tomography;Proteins;proteomic signature;Proteomics;Reproducibility;Research Project Grants;tau Proteins;therapeutic target

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT: Identifying peripheral drivers of Alzheimers disease using plasma proteomics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

PI_NAMEs: RAPP, PETER R (contact)

PROJECT_TERMS: Address;Age;age related;age related changes;Age-associated memory impairment;age-related disease;aged;Aging;Alzheimer's Disease;animal data;Animal Model;animal old age;Animals;Area;Attention;Baltimore;Basic Science;Behavioral;Biochemical;Brain;Brain region;calbindin-D28K;Calcium;Cell Count;Cerebellar Cortex;Cerebellum;Characteristics;Cognitive;Cognitive aging;cognitive capacity;comparative;Data;Dementia;disorder risk;Exhibits;experience;experimental study;Foundations;Health;Human;human old age (65+);Individual;Individual Differences;insight;Investigation;juvenile animal;Kinetics;Link;Longitudinal Studies;Measures;medial temporal lobe;Mediator;Memory;Memory impairment;memory recognition;Modeling;Monkeys;Motor;neural;neural network;Neurobiology;neurochemistry;Neurocognitive;neuroimaging;Neurons;novel;Older Population;Outcome;Output;Pattern;Phenotype;pre-clinical;Pre-Clinical Model;preference;Prefrontal Cortex;preservation;Process;protein biomarkers;Proteins;Publishing;Purkinje Cells;Quality of life;Rattus;Reporting;Research;Research Project Grants;resilience;Role;Series;social;social cognition;Social Interaction;social neuroscience;spatial memory;Stimulus;System;Testing;translational approach;translational study;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Neurocognitive Aging: Experience-Dependent Dynamics, Plasticity and Network Contributions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Affect;Age;age effect;age related;Age Years;aged;Aging;Alzheimer's Disease;animal old age;basal forebrain;behavior test;Brain;Cells;cholinergic;cholinergic neuron;Chronology;Cognitive;Cognitive aging;cohort;comparative;comparison group;Desire for food;Elderly;Exhibits;Human;Hypertrophy;Impaired cognition;Impairment;Individual;Individual Differences;lens;Macaca;Macaca mulatta;Maps;mature animal;Measures;medial temporal lobe;Modeling;Monkeys;Neuroanatomy;Neurobiology;Neurocognitive;Neurons;Neuropsychology;Outcome;Pattern;Performance;Persons;Population;Prefrontal Cortex;Primates;Publishing;Rattus;Recording of previous events;Research Project Grants;resilience;Rodent Model;Sampling;sex;System;Testing;translational model;Visit;Work;young adult

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Primate Models of Neurocognitive Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: BOUHRARA, MUSTAPHA  (contact)

PROJECT_TERMS: Acceleration;Affect;age-related disease;Aging;aging related;Alzheimer's Disease;Amyloid;autosomal dominant Alzheimer's disease;Axon;axonal degeneration;biobank;Biological Markers;Brain;cardiovascular fitness;Cerebrum;Cholesterol;Cognitive;cohort;Collaborations;Complex;Data;Dementia;Democracy;Demyelinations;density;Early Diagnosis;Ensure;functional decline;Functional disorder;Functional impairment;Funding;Germany;Goals;Health;Hypertension;Image;imaging biomarker;Impaired cognition;Impairment;improved;insight;Intellectual Property;Intervention;Iron;Lawyers;Legal patent;Link;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;mild cognitive impairment;Modeling;Monitor;Motor;Myelin;Myelin Proteins;myelination;Nerve Degeneration;neuroimaging;neuroinflammation;normal aging;Obesity;Oligodendroglia;Pattern;Positron-Emission Tomography;Prevention;programs;Property;Property Rights;Protocols documentation;Research;Research Project Grants;Risk Factors;Role;Secure;Senile Plaques;Sister;Structure;tau Proteins;Techniques;theories;United States National Institutes of Health;Vascular Dementia;Water;white matter;white matter change;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Cerebral Microstructure in Aging and Dementia using Advanced Quantitative MRI


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BENJAMINI, DAN  (contact)

PROJECT_TERMS: Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Area;Astrocytes;astrogliosis;Autopsy;axon injury;Biological Markers;blind;Brain;brain control;brain dysfunction;Central Nervous System;Cerebral cortex;Cerebrum;Chemicals;Cicatrix;Clinical;Cognition;Cognitive;Complex;Correlation Studies;Data;demented;Dementia;Demyelinations;Deposition;detection method;Diagnostic Imaging;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Elderly;Evaluation;Exhibits;glial activation;Glial Fibrillary Acidic Protein;Goals;Histologic;histological image;Histology;Histopathology;Image;imaging biomarker;imaging modality;immunoreactivity;Impaired cognition;improved;in vivo;in vivo imaging;Individual;Injury;innovation;interest;Knowledge;Lesion;Linear Regressions;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;member;meter;Methods;Microscopic;microscopic imaging;Microscopy;millimeter;Modality;multimodality;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;neuroinflammation;Neuronal Injury;Neurons;neuropathology;non-demented;non-invasive imaging;novel marker;Pathology;Positron-Emission Tomography;Process;quantitative imaging;Radiology Specialty;Reaction;Relaxation;repaired;Research;resilience;Resolution;response;response to injury;Sampling;Sensitivity and Specificity;sex;Signal Transduction;Slice;Specificity;Specimen;Stains;Standardization;Structure;Symptoms;tau Proteins;tau-1;Tauopathies;Techniques;tissue injury;Tissue Sample;Tissues

PROJECT_TITLE: Alzheimers Disease Project: Quantitative imaging of astrogliosis and neuroinflammation


NIH_SPENDING_CATS: Aging;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition

PROJECT_TERMS: Anthocyanins;Apigenin;Biological Assay;Cell Aging;Cell Culture Techniques;Cell Death;Cell membrane;Cell Survival;cell type;Cells;cellular targeting;Cessation of life;chemoproteomics;Dietary Flavonoid;Dose;Drug Screening;efficacy evaluation;epicatechin;Epithelial Cells;fisetin;Flavonoids;Future;genetic manipulation;IFIH1;Intake;Intervention;Ions;kidney cell;Mass Spectrum Analysis;Measures;meter;Methods;Modeling;monocyte;myricetin;Natural Compound;novel;Pathway interactions;POLB gene;Procyanidins;Proteins;Proteomics;Quercetin;renal epithelium;response;screening;senescence;senescent cell;senolytics;Specificity;TXNIP gene;uptake;Work

PROJECT_TITLE: Evaluating the Cell-Type Specificity and Cellular Targets of Senotherapuetic Compounds with Unknown Mechanisms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: ADAMTS;Alzheimer's Disease;Alzheimer's disease related dementia;Astrocytes;brain cell;Cell Aging;Cell Culture Techniques;cell type;Cells;Conditioned Culture Media;Data;Data Set;Databases;Disease;Dose;Doxorubicin;drivers of aging;Engineering;extracellular vesicles;Future;Genes;Genetic Risk;genetic variant;Genetic Variation;Genotoxic Stress;Hand;Heritability;Human;human data;Image;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Laboratories;Link;Methods;Modeling;multiple omics;Neurodegenerative Disorders;Neuroglia;Neurons;Oligodendroglia;Phenotype;Population;prion-like;Proteins;Proteomics;Protocols documentation;repository;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk;risk variant;Sampling;senescence;senescence associated secretory phenotype;senescent cell;Senotherapeutic;Stress;Testing;transcriptomics;transmission process;Variant;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT:  CARD - Senescent Phenotypes of Isogenic iPSC-Derived Alzheimer's Disease and Related Dementia Models at Cellular Resolution


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: SEN, RANJAN  (contact)

PROJECT_TERMS: 3-Dimensional;activation-induced cytidine deaminase;Age;Aging;Alleles;Antigen Receptors;B-Cell Development;B-Lymphocytes;Bone Marrow;Bone Marrow Transplantation;CCCTC-binding factor;Cell Nucleus;Cells;Cellular biology;Chromatin;Chromatin Structure;chromosome movement;Confocal Microscopy;Defect;derepression;Development;Distant;Ensure;Environment;Enzymes;Epigenetic Process;Gene Expression;Genes;genomic locus;Goals;Heavy-Chain Immunoglobulins;Hematopoiesis;IGH@ gene cluster;Immune response;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Lamins;Location;Lymphocyte;Movement;Mus;Mutate;Myelogenous;Myeloid Cells;Nuclear;Nuclear Matrix-Associated Proteins;Paper;Pathway interactions;Positioning Attribute;Process;programs;Publishing;Receptor Gene;recombinase;Role;Scaffolding Protein;single-cell RNA sequencing;stem cells;three dimensional structure;Tissue-Specific Gene Expression;Tissues;transcription factor;V(D)J Recombination;YY1 Transcription Factor

PROJECT_TITLE: Chromosome movements that regulate tissue-specific gene expression


NIH_SPENDING_CATS: Aging;Genetics

PROJECT_TERMS: Aging;anti-IgM;Antibodies;Area;B Cell Proliferation;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;Binding;Cell Adhesion Molecules;Cell Line;Cell Maintenance;Cell Survival;cell type;Cells;chromatin immunoprecipitation;Cleavage Under Targets and Release Using Nuclease;crosslink;cytokine;Cytoplasm;DNA Damage;endoplasmic reticulum stress;Family;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;GTF2I gene;Helper-Inducer T-Lymphocyte;Human;Hypoxia;Immune response;In Vitro;inducible gene expression;Inflammatory;Interleukin-1;Interleukin-6;Mediating;Modeling;Molecular;Mus;NF-kappa B;Nuclear;Nuclear Translocation;Pathway interactions;Population;Procedures;Reactive Oxygen Species;receptor;Receptor Activation;Receptor Signaling;Research;response;Role;sensor;Signal Transduction;Specificity;Spleen;Stimulus;Stress;System;Systems Biology;T cell response;T-Lymphocyte;targeted treatment;TFII Transcription Factors;TNF gene;TNFRSF5 gene;transcription factor;Translating;Work

PROJECT_TITLE: NF-kB activation and function in B lymphocytes


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

PI_NAMEs: SUNG, MYONG-HEE  (contact)

PROJECT_TERMS: Aging;Behavior;Biochemical;Biology;Bone Marrow;Brain;c-rel Proto-Oncogenes;Cell Physiology;Cell Survival;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Ear;Exhibits;Fibroblasts;Frequencies;Gene Expression Regulation;Genetic Transcription;Genome engineering;genome sequencing;genomic locus;Immune;Immunity;improved;in vivo;Incubated;insight;Knock-in Mouse;Label;Lasers;Ligands;Link;live cell imaging;live cell microscopy;machine learning model;Macrophage;Manuscripts;mathematical model;Mediating;Methods;Microbe;Microglia;Microscope;Microscopy;Modeling;Mouse Strains;Mus;novel;Nuclear;Paper;Pathogenicity;Pattern;Process;Proteins;Publications;Publishing;receptor;Reporter;Research;response;Scanning;Signal Transduction;Signaling Molecule;Southern Blotting;Stimulus;System;T-Lymphocyte;Time;Tissues;transcription factor;transmission process;whole genome

PROJECT_TITLE: Functional decoding of signaling dynamics in single immune cells


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

PROJECT_TERMS: Antibody Repertoire;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Binding;Binding Sites;Characteristics;Chromatin;Chromatin Structure;Code;combinatorial;CRISPR/Cas technology;Development;Distant;E protein;enhancer binding protein;Enhancers;EP300 gene;Epigenetic Process;Event;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Generations;Genes;Genetic Recombination;Genetic Transcription;Genomics;Goals;Heavy-Chain Immunoglobulins;Hematopoietic stem cells;histone modification;human disease;IGH@ gene cluster;insight;Lymphocyte;Manuscripts;Molecular Conformation;Mus;Mutate;Mutation;Preparation;Property;Publications;Publishing;Role;Single Nucleotide Polymorphism;Site;Somatic Cell;Study models;T-Cell Receptor;T-Lymphocyte;Tissue-Specific Gene Expression;transcription factor;V(D)J Recombination;virtual;Work;YY1 Transcription Factor

PROJECT_TITLE: Gene Regulation in Lymphocytes


NIH_SPENDING_CATS: Aging;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: Address;Affect;age related;age related changes;Aging;ATAC-seq;Baltimore;base;CD4 Positive T Lymphocytes;Cell Aging;Cell Physiology;Cells;Characteristics;Chromatin;Chromatin Structure;cohort;Collaborations;COVID-19;cytokine;Cytoplasm;Data;DNA Damage;DNA Methylation;Epigenetic Process;epigenomics;Gene Expression;Genetic;Genetic Transcription;Goals;hallmarks of aging;Human;hypoxia inducible factor 1;Immune;Immune response;In Vitro;Inflammatory;Laboratories;Longitudinal Studies;Lymphocyte;Measures;Memory;Methylation;monocyte;NF-kappa B;Oxidation-Reduction;Oxidative Stress Induction;peripheral blood;Phase;Phenotype;Post-Translational Protein Processing;Procedures;Proliferating;Proteins;Proteomics;Publications;response;RNA;Role;sample collection;Sampling;Signal Transduction;Testing;Tissues;transcription factor;Transcription Factor AP-1;transcriptomics;vaccine evaluation;vaccine response

PROJECT_TITLE: Age-associated alterations in pro-inflammatory gene expression in humans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Address;Age;age related;age-related disease;Aging;Alzheimer's disease model;Amyloid beta-Protein;animal old age;Antigen Presentation;ATAC-seq;Bioinformatics;Biology of Aging;Brain;cell behavior;Cells;Characteristics;Chromatin;Chronic;Circulation;Coculture Techniques;Collaborations;computerized tools;cytokine;Data;Defect;Deterioration;Development;Discipline;DNA;DNase I hypersensitive sites sequencing;Elderly;Epigenetic Process;epigenomics;Gene Expression;Gene Expression Regulation;Genes;Genome;genomic tools;High-Throughput Nucleotide Sequencing;Histocompatibility Antigens Class I;HMGN Proteins;HMGN1 gene;HMGN2 gene;Homeostasis;human induced pluripotent stem cells;Immune;Immune system;Immunity;Impairment;improved;Inflammation;Inflammatory;juvenile animal;Knock-in Mouse;knowledge integration;Macrophage;Manuscripts;Mathematics;Methodology;Methods;Microglia;model organism;Molecular Biology;mouse model;Mus;neuroinflammation;Neurons;Nucleosomes;Nucleotides;old mice;Pathogenicity;Pathologic;Pattern;Persons;Play;Process;programs;Proliferating;Protocols documentation;Regulation;Reporting;Role;Signal Transduction;Software Tools;Tissues;tool;transcription factor;Up-Regulation;uptake;Vaccination

PROJECT_TITLE: Epigenomic analysis of primary immune cells from young and old animals


PI_NAMEs: GOROSPE, MYRIAM  (contact)

PROJECT_TERMS: Adopted;Affect;age related changes;age-related disease;Aging;aging process;Alternative Splicing;Apoptosis Regulation Gene;Atherosclerosis;Attention;Binding;Binding Proteins;Biological Assay;Biotinylation;Blood Vessels;Brain-Derived Neurotrophic Factor;Cardiovascular system;Cell Aging;Cell Physiology;Cell Survival;Cells;Cellular biology;clinical investigation;Communication;crosslink;Cultured Cells;Cyclin-Dependent Kinase Inhibitor;Cyclins;cytokine;Diploidy;extracellular;extracellular vesicles;Fibroblasts;Gene Expression;Gene Expression Profile;Growth Factor;hallmarks of aging;Human;human tissue;Immunoprecipitation;In Vitro;Individual;Inflammation;insight;interest;Intervention;Journals;life span;Link;Malignant Neoplasms;Measures;Messenger RNA;Metalloproteases;MicroRNAs;Modification;mouse model;mRNA Expression;Mus;muscle form;Muscular Atrophy;mutant;nanopore;Nature;Nucleic Acids;Oncoproteins;Organ;overexpression;Participant;particle;Pathologic;Pathology;Pattern;Phenotype;Physiological;Physiology;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;Process;Production;programs;Proliferating;protein biomarkers;protein expression;protein function;Proteins;Proteome;Reporter;Research;Ribonucleoproteins;RNA;RNA Interference;RNA-Binding Proteins;Role;Science;senescence;senescence associated secretory phenotype;senescent cell;Signal Pathway;Signal Transduction;skin biopsy;src-Family Kinases;Sweat Glands;System;Tissue Microarray;Tissues;transcriptome;transcriptome sequencing;Translating;Translations;Tumor Suppressor Proteins;Untranslated RNA;Work

PROJECT_TITLE: Influence of Post-transcriptional Gene Regulation on Cell Senescence and Aging


PROJECT_TERMS: age related decline;Aging;aging related;Animals;Area;Autophagocytosis;blood glucose regulation;Cachexia;Cell Nucleus;Cell Physiology;Collaborations;Development;Energy consumption;Energy Metabolism;Event;glucose metabolism;Human;Impairment;insulin regulation;interest;Journals;Knock-out;lipid biosynthesis;lipid metabolism;Messenger RNA;Metabolic;Mitochondria;mitochondrial metabolism;Mitochondrial RNA;Molecular and Cellular Biology;mouse model;Muscle;Muscle Cells;muscle regeneration;Myoblasts;myogenesis;Natural regeneration;Neurons;overexpression;Pancreas;Post-Transcriptional Regulation;posttranscriptional;Process;Production;programs;Reporting;RNA-Binding Protein FUS;RNA-Binding Proteins;Role;sarcopenia;senescence;Structure;Structure of beta Cell of islet;Tissues;transcriptome;Untranslated RNA

PROJECT_TITLE: Post-transcriptional regulation of energy usage: glucose and lipid metabolism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Women's Health Research

PROJECT_TERMS: 2 year old;Age Months;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Autopsy;Behavioral;biobank;Biological;Biological Specimen Banks;Brain;Cognitive;Cognitive aging;cognitive function;cognitive reserve;Collection;Data;data centers;data management;data sharing;Dedications;design;Deterioration;Diffusion Magnetic Resonance Imaging;digital data;Disease Progression;effective therapy;Extramural Activities;Female;functional MRI scan;Goals;Individual;Individual Differences;interest;late life;Long-Evans Rats;longitudinal analysis;longitudinal dataset;Magnetic Resonance;male;Measurement;Mediator;Modeling;Neurocognitive;Neurodegenerative Disorders;neuroimaging;neuropathology;Outcome;Pathologic;Peripheral;Persons;Phase;Phenotype;phenotypic data;Physiological;Plasma;Rattus;Research;Research Project Grants;resilience;Resources;Sampling;Scanning;sex;Sex Differences;tissue archive;Tissues;Vaginal Douching

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: STARRRS: an open rat resource for the study of reserve and resilience against Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: AD transgenic mice;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;APP-PS1;Asthma;Big Data;Biochemical Pathway;Biological Assay;Blood;Brain;Cell Culture Techniques;clinical practice;Data;Data Analyses;Data Set;Dementia;Diabetes Mellitus;Drug Prescriptions;drug repurposing;drug testing;Epilepsy;Evaluation;experimental study;Exposure to;Fatty Acids;FDA approved;Glucose;health record;Hippocampus;Hypertension;Impairment;in vivo;Link;Medicare;Medicine;Metabolism;molecular phenotype;mouse model;Mus;novel therapeutics;Older Population;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phospholipid Metabolism;protective effect;randomized, clinical trials;Research;Research Project Grants;Rheumatoid Arthritis;screening;Services;Signal Transduction;sound;Synaptic plasticity;Testing;transgenic model of alzheimer disease;Validation

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: New Cures from Old Medicines - Targeting abnormal metabolism in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurosciences

PROJECT_TERMS: Address;Adult;age difference;Aging;aging brain;Amyloid;Architecture;Astrocytes;Atrophic;Axon;Baltimore;Biological;Brain;Cell membrane;Cell Physiology;Cerebrum;Characteristics;Chemicals;Clinical;Cognitive;cognitive function;cohort;Complex;Coupled;Data;data acquisition;Dementia;Dendritic Spines;density;design;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Epigenetic Process;Fiber;Frequencies;Gel;Genetic;Goals;gray matter;healthy volunteer;Histologic;Human;human old age (65+);Image;Impaired cognition;Investigation;Laboratories;life span;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Methods;Microscopic;mild cognitive impairment;millimeter;Morphology;Myelin;neurofilament;neuroimaging;neuroinflammation;Neurons;normal aging;novel;Outcome;Participant;Powder dose form;pre-clinical;Property;Protocols documentation;Relaxation;Reproducibility;Resolution;Scanning;Shapes;Structure;Synapses;Testing;Thick;Time;Tissues

PROJECT_TITLE: Linking brain micro- and meso-structure with cognitive functioning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;APP-PS1;Bile Acids;Biological;Biological Assay;Calcium Signaling;candidate validation;Cell Culture Techniques;Cholesterol;Clinical;Clinical Data;Cytokine Signaling;Data Set;Disease;DNA Repair;Drug Targeting;Drug usage;Electrophysiology (science);experimental study;FDA approved;GPBAR1 gene;Hippocampus;Human;Impaired cognition;Impairment;in vivo;Incidence;Long-Term Potentiation;Methods;Molecular;molecular phenotype;multiple omics;Mus;Neurites;Older Population;Outcome;Pathway interactions;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Randomized, Controlled Trials;receptor;Research Project Grants;Role;screening;Slice;src-Family Kinases;STAT3 gene;Synaptic plasticity;Systems Biology;tau aggregation;tau-1;Testing;Time;TOP1 gene;Toxic effect;transgenic model of alzheimer disease;Validation

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Experimental validation of candidate AD treatments identified by multi-OMICS analyses and real-world clinical evidence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PROJECT_TERMS: 8-Oxoguanine DNA Glycosylase;Age;age acceleration;age related;Alzheimer's Disease;base;Cell Physiology;Chemical Agents;Disease Progression;DNA;DNA Damage;DNA Repair;Endogenous Factors;Ensure;Environmental Risk Factor;Exogenous Factors;Exposure to;genome integrity;Genome Stability;Genomic Instability;Guanine;Health;Impairment;Inherited;Link;Maintenance;Metabolic;Mitochondria;Mitochondrial DNA;Mutation;Nerve Degeneration;Nuclear;OGG1 gene;oxidative damage;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Physiology;Play;Predisposition;preservation;prevent;Production;Reactive Oxygen Species;repaired;Research Project Grants;Role;Source;Structure;Ultraviolet Rays

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Role of OGG1 in mitochondrial health


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Nanotechnology

PI_NAMEs: MARAGKAKIS, MANOLIS  (contact)

PROJECT_TERMS: Age;age effect;age group;age related changes;Aging;aging process;biological adaptation to stress;Cell Survival;Communities;Data;EIF-2alpha;Extramural Activities;Genetic Transcription;Immune system;insight;Kinetics;Label;Length;Macaca mulatta;Machine Learning;Messenger RNA;Metabolic;Mission;Modification;Names;nanopore;nonhuman primate;Oxidative Stress;Oxidative Stress Induction;Peripheral Blood Mononuclear Cell;Phosphorylation;Poly(A) Tail;Poly(A)+ RNA;Primates;Protein Isoforms;Protocols documentation;Research Project Grants;response;RNA;RNA metabolism;Role;sex;sodium arsenite;Stress;tool;Uridine;Variant;Work

PROJECT_TITLE: Discover RNA metabolism dynamics during stress response of the aging primate immune system


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

PI_NAMEs: WANG, WEIDONG  (contact)

PROJECT_TERMS: Address;Adult;age related;Aging;Anti-Inflammatory Agents;autism spectrum disorder;Autoantibodies;Behavior;Behavioral;behavioral impairment;Bone Marrow Cells;Brain;CD36 gene;CD47 gene;Cd68;CD86 gene;Central Nervous System Diseases;Characteristics;cytokine;Data;Defect;Dementia;Development;Disease;DLG4 gene;DNA;enzyme activity;experimental study;FMR1 gene;Genetic Transcription;Heterochromatin;Homeostasis;Host Defense;Housekeeping;Human;IL4 gene;IL6 gene;Immune response;Immune System Diseases;Immunologics;Infection;Inflammatory;Interleukin-10;Knock-in;Knockout Mice;life span;Link;Lipopolysaccharides;Maintenance;Mediating;Membrane;Messenger RNA;Microglia;Molecular;mRNA Translation;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutate;Mutation;Nervous System Disorder;neurogenesis;neuroinflammation;Neurologic;Neurons;Numerical Chromosomal Abnormality;Phagocytes;Phagocytosis;Phenotype;phenotypic biomarker;Play;postnatal;Proteins;Publishing;Reporting;Research;RNA;RNA Binding;Role;Schizophrenia;Serum;Signal Transduction;Small Interfering RNA;Splenocyte;Stimulus;Synapses;Synaptic plasticity;synaptic pruning;TLR4 gene;TNF gene;Topoisomerase

PROJECT_TITLE: Investigating roles of Topoisomerase 3b (TOP3B) in LPS-induced microglia-mediated neuroinflammation in mouse


NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Adopted;Adult;Affect;age related;Aging;aging related;Attenuated;Cell Aging;Cells;Dasatinib;differential expression;Disease;Elderly;exhaustion;Fibroblasts;frailty;functional decline;functional loss;Gene Expression;Genes;Genetic;Growth;Hand Strength;Health;Heterogeneity;Human;Impairment;improved;insight;Intervention;Ionizing radiation;Maintenance;Membrane Proteins;Molecular;mortality;Mus;Muscle;muscle aging;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Mutagens;Myoblasts;myogenesis;Natural regeneration;old mice;Oncogenes;Pattern;Phenotype;Process;programs;Quercetin;Reactive Oxygen Species;receptor;RNA;Role;sarcopenia;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell analysis;Skeletal Muscle;Source;stem cells;Therapeutic;trait;transcriptome;walking speed

PROJECT_TITLE: Senescence of muscle progenitor cells: impact on human myogenesis and muscle aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Endocannabinoid System Research;Headaches;Migraine;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Physical Rehabilitation;Prevention;Rehabilitation

PI_NAMEs: RAMSDEN, CHRISTOPHER  (contact)

PROJECT_TERMS: Affect;age-related disease;Alzheimer's Disease;Alzheimer’s disease biomarker;Amygdaloid structure;analog;Analytical Chemistry;Astrocytes;Autopsy;Biochemical;Biological;Biological Assay;Biological Markers;Body Composition;Brain Stem;Cell Line;Cell Nucleus;Cellular Assay;Chronic Headaches;chronic pain;chronic pain management;Chronic pain syndrome;Clinical;clinical center;clinical efficacy;Collaborations;craving;design;Diet;Dietary Fatty Acid;Dietary Intervention;dietary manipulation;Disease;Doctor of Medicine;drug candidate;drug discovery;Endocannabinoids;entorhinal cortex;follow-up;Goals;Hippocampus;Human;human tissue;Immunohistochemistry;Induced pluripotent stem cell derived human neuron;Inflammation;insight;Intervention;Link;link protein;lipid mediator;lipid metabolism;Lipid Peroxidation;Lipids;Lipoproteins;Liquid Chromatography;Mediator;Medical;Migraine;mild cognitive impairment;Mission;Modeling;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurologic;novel;older adult;oxidized lipid;Pain;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physical Medicine;Physical Rehabilitation;prevent;primary endpoint;Proteins;Pruritus;Publications;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;Refractory;Research Personnel;Resistance;Rodent;Role;Satiation;small molecule;Specimen;Synthesis Chemistry;synthetic drug;tandem mass spectrometry;Techniques;Testing;Tissues;Translating;translational approach;Translations;United States National Institutes of Health

PROJECT_TITLE: Dysfunctional lipid metabolism and peroxidation in chronic pain and neurodegeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Diabetes;Genetics;Neurodegenerative;Neurosciences;Nutrition

PROJECT_TERMS: 3xTg-AD mouse;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid deposition;Animal Model;APP-PS1;Area;Behavior;Blood Glucose;Brain;Breeding;Calcium;Calcium Signaling;Calories;CB1 knockout;Cells;Cerebrum;Clinical;Crossbreeding;Data Collection;Diabetes Mellitus;Diet;Endoplasmic Reticulum;experimental study;Female;Gene Expression Profiling;Genes;Hormones;Human;Hyperglycemia;Hyperinsulinism;Hyperlipidemia;Hypoglycemia;In Situ Hybridization;Insulin;Insulin Receptor;Insulin Resistance;insulin secretion;insulin signaling;Lead;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;mouse model;Mus;Neurons;novel;Ontology;Pancreas;Pathologic Processes;Pathway interactions;Peripheral;Phenotype;prevent;Proteins;Proteomics;receptor;Structure of choroid plexus;Testing;Tissue-Specific Gene Expression;Wild Type Mouse

PROJECT_TITLE: CLINICAL PROJECT:  Deconstructing insulin in the brain


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;Antibodies;antibody libraries;Architecture;Biological Markers;Brain region;Brain Stem;Categories;Classification;cohort;Collaborations;Data;Data Set;design;disability;Disease;Disease Progression;effective therapy;entorhinal cortex;Epitopes;Future;Genes;Goals;healthy aging;high resolution imaging;Hippocampus;Human;human tissue;hyperphosphorylated tau;Image;Immune;Immunohistochemistry;Label;Late Onset Alzheimer Disease;Link;lipid metabolism;Lipids;Mediator;Metabolic Pathway;mild cognitive impairment;mitochondrial dysfunction;Molecular;molecular marker;Morphology;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurodegenerative Disorders;novel;novel strategies;novel therapeutics;Pathogenesis;Pathologic;Pathology;Pathway interactions;Play;prevent;Process;Proteins;Protocols documentation;Publishing;Research Project Grants;Risk Factors;RNA;Signal Transduction;societal costs;Source;Specimen;Synapses;Techniques;Tissues;Validation;Variant;Western Blotting

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Dysfunctional lipid metabolism in Alzheimer's Disease


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PROJECT_TERMS: age related decline;age-related disease;Aging;BMP2 gene;Cell Aging;Cell division;cell injury;Cells;chemokine;clinical application;Conditioned Culture Media;cost effectiveness;cytokine;Disease;embryo tissue;Exhibits;extracellular vesicles;healthspan;HLA G antigen;Human;Immune;in vivo;Inflammatory;Link;MAP Kinase Gene;Membrane Proteins;Mesenchymal Stem Cells;Molecular Profiling;mouse model;Mus;organ regeneration;Organism;Osteogenesis;Peptide Hydrolases;Physiology;Population;Positioning Attribute;Proliferating;Reporting;Research;response;senescence;senescence associated secretory phenotype;senescent cell;Senotherapeutic;Signal Pathway;Signal Transduction;Therapeutic;therapy development;Time;Tissues;trait;trophoblast;trophoblast stem cell;tumor

PROJECT_TITLE: Analysis of the Impact Trophoblast-derived Extracellular Vesicles in Cell Senescence


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Sarcopenia

PROJECT_TERMS: Ablation;Acute;age related;aged;Aging;Attenuated;Cell Aging;cell type;Cells;CTSD gene;Diphtheria Toxin;diphtheria toxin receptor;experimental study;extend lifespan;Flow Cytometry;GDF15 gene;glycoprotein NMB;Homeostasis;Immune;improved;inducible Cre;Inflammatory;Injury;injury and repair;Integral Membrane Protein;interest;Knock-in Mouse;Link;Macrophage;male;Mediation;Messenger RNA;Metabolism;Molecular;mouse model;Movement;Mus;muscle aging;Muscle Fibers;muscle form;Muscle function;Muscle satellite cell;Muscular Atrophy;Natural regeneration;Organ;Phenotype;Physiologic Thermoregulation;Play;Population;Process;progenitor;Proteins;Regenerative capacity;repaired;response to injury;Role;senescence;Skeletal Muscle;skeletal muscle growth;Skeletal muscle injury;tissue repair;Tissues;tumor progression;Vaccination

PROJECT_TITLE: Analysis GPNMB + Macrophages in Skeletal Muscle Aging


NIH_SPENDING_CATS: Aging;Biotechnology

PROJECT_TERMS: age-related disease;Aging;Catalogs;Cell Aging;Cell Lineage;cell type;Cells;chemotherapy;Cultured Cells;Disease;driving force;Goals;Human;human tissue;in vivo;in vivo Model;Knowledge;Learning;Manuscripts;Modeling;Organ;Organism;Physiology;Proteome;Proteomics;senescence;senescent cell;Tissues;transcriptome;transcriptomics;Writing

PROJECT_TITLE: A broad catalog of transcriptomic and proteomic markers for human cell senescence


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Age;age related;age-related disease;Blood;Blood Circulation;Body Fluids;Brain;Cardiovascular system;Cellular biology;Development;Diagnostic;diagnostic biomarker;Diameter;differential expression;Disease;disease model;extracellular;extracellular vesicles;FABP1 gene;Fatty acid glycerol esters;Heart;Heterogeneity;International;Journals;Kidney;Knowledge;Label;Liver;Lung;Membrane Proteins;Molecular;Mus;old mice;Organ;particle;Pathology;potential biomarker;protein biomarkers;Proteins;Proteome;Publishing;Serum;Site;Societies;Surface;System;therapeutic target;Tissues;Work

PROJECT_TITLE: Identification of Organ-Specific Small Extracellular Vesicles in Mouse Serum


PI_NAMEs: HERMAN, ALLISON  (contact)

PROJECT_TERMS: Address;Affect;Age;aged;Animal Diseases;Aorta;Arteries;ATAC-seq;Atherosclerosis;Biological Assay;Brain;Cardiovascular Diseases;Cell Aging;Cell Nucleus;Cells;Chromatin;comorbidity;Complex;Disease;Dissociation;DNA;DNA Mutational Analysis;Elements;Fatty acid glycerol esters;feeding;Female;Flow Cytometry;Freezing;Functional disorder;gain of function mutation;Gene Expression;Genes;Heart;Heterogeneity;High Fat Diet;human disease;Immune;Impairment;improved;Individual;Inflammatory;Injections;interest;Kidney;Liver;Lung;male;multiple omics;Mus;Mutation;Older Population;Organ;Organism;Peripheral;Phenotype;programs;Proteomics;Protocols documentation;Resolution;RNA;Role;Sampling;senescence;senescent cell;senolytics;Somatic Mutation;Sorting;Spleen;Surveys;Techniques;Testing;Therapeutic;Tissue Banks;Tissues;transcriptome sequencing;transcriptomics;Transposase;Virus;Wild Type Mouse

PROJECT_TITLE: Multiomic survey of secondary senescence in peripheral tissues from atherosclerotic mice


PROJECT_TERMS: Acceleration;Affect;Age;age related;age related decline;aged;Aging;aging process;Animal Model;Apoptotic;Arterial Fatty Streak;arterial stiffness;Arteries;Atherosclerosis;BAX gene;Blood Vessels;Cardiovascular Diseases;Cell Aging;Cell Culture Techniques;Cell Death;Cell Survival;cell type;Cells;Chronology;Development;DNA Damage;Doxorubicin;Effectiveness;Elasticity;Endothelial Cells;experience;Extracellular Matrix;healthy aging;Human;Hypertension;improved;In Vitro;Intervention;knock-down;Link;Location;Macrophage;Messenger RNA;Mus;Organism;Outcome;Pathology;Pathway interactions;Phase;Phosphorylation;Population;prevent;Process;Proteins;RB1 gene;Role;senescence;senescent cell;senolytics;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Structure;Telomere Shortening;Therapeutic;therapeutic target;Thick;Time;Tissues;transcriptome sequencing;transcriptomics;Transfection;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Determining the Chronological Onset of Senescence in the Aging Vasculature


PROJECT_TERMS: age related;age-related disease;Aging;aging related;Alternative Splicing;Antisense Oligonucleotides;Aorta;Atherosclerosis;Biological Process;Cell Aging;Cell Culture Techniques;cell type;Cells;Coupled;detection sensitivity;differential expression;Fibroblasts;Funding;Human;improved;in vivo;Intervention;Length;Liver;Messenger RNA;Modeling;Mus;nanopore;normal aging;novel strategies;Organism;Proliferating;Protein Isoforms;Proteome;Ribosomes;RNA Splicing;Role;senescence;senomorphic;single cell analysis;Surveys;Tissues;Transcript;Variant;Work

PROJECT_TITLE: Splice-switching antisense oligonucleotides (SSOs) as a senomorphic intervention


PROJECT_TERMS: Affect;Age;age-related disease;aging related;Biology;Cell Aging;Cell Proliferation;Coat Protein Complex I;Complex;cytokine;Defect;Exhibits;extracellular vesicles;Fibroblasts;Genes;Golgi Apparatus;Inflammatory;Intracellular Transport;Manuscripts;Mediating;member;Modeling;Morphology;Multiple Abnormalities;Organelles;Phenotype;Production;Proteins;Proteomics;Role;senescence;senescent cell;senomorphic;Structure;trafficking;transcriptomics;uptake;Vesicle

PROJECT_TITLE: Intracellular vesicle trafficking in senescent cells  role of the Golgi complex?


NIH_SPENDING_CATS: Aging;Genetics

PROJECT_TERMS: Ablation;age related;Aging;aging mechanism;aging related disease;Amino Acids;B-Lymphocytes;Biological Assay;Biology;Blood;Cell Aging;Cell division;cell type;Cells;Chromosomes;Chronic;Chronic Lymphocytic Leukemia;Complex;Coupled;Cutaneous Melanoma;Data;Defect;Detection;Disease;DNA Damage;Dyskeratosis Congenita;Ensure;Exhibits;Functional disorder;Genes;Genetic Recombination;Genome;genome integrity;Goals;hallmarks of aging;Heterozygote;Homeostasis;In Situ;in vivo;Individual;Inflammatory;Knock-out;Length;Ligase;Link;Malignant Neoplasms;Mammals;Manuscripts;Mass Spectrum Analysis;Mediating;Mitochondria;Modeling;Mus;mutant;Mutation;Nature;Nerve Degeneration;novel;Nucleoproteins;overexpression;Pathway interactions;Phenotype;Play;protein complex;protein protein interaction;Proteins;Protocols documentation;Publishing;recruit;repaired;Reproducibility;response;Role;Signal Transduction;Skeletal Muscle;Structure;Telomerase;telomere;Telomere Length Maintenance;Telomere Shortening;Telomere-Binding Proteins;TERF1 gene;TINF2 gene;tool;Update;Western Blotting

PROJECT_TITLE: Investigating a novel shelterin-associated protein complex in telomere protection


PROJECT_TERMS: Affect;age related;age-related disease;Aging;aging related;Angiogenic Factor;Animal Model;Aorta;Area;arterial stiffness;Arteries;Atherosclerosis;Biology of Aging;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;CCL2 gene;Cell Adhesion Molecules;Cell Aging;cell type;Cells;chemokine;clinical investigation;Coagulation Process;Collagen;Communication;cytokine;Deposition;Development;Disease;epigenetic regulation;Exhibits;Extracellular Matrix;Fibroblasts;Gene set enrichment analysis;Genes;Genomics;healthspan;Heart;Heterogeneity;Human;IL8 gene;improved;in vivo;Inflammation;Inflammatory;innovation;Intercellular adhesion molecule 1;interest;Interleukin-1;Interleukin-6;Intervention;Journals;Left;mouse model;Mus;Nature;Nucleic Acids;Organ;Pathway interactions;Pharmaceutical Preparations;Population;Printing;Process;Production;Proteins;Publishing;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;single molecule;single-cell RNA sequencing;systemic inflammatory response;T-Lymphocyte;Techniques;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Vascular Diseases;Vascular Endothelial Growth Factors

PROJECT_TITLE: Analysis of vascular cell senescence to identify interventions in atherosclerosis


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nanotechnology

PROJECT_TERMS: age related;age-related disease;Aging;aging related;Alternative Splicing;Aorta;aortic arch;ApoE knockout mouse;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;Bar Codes;base;Biological Process;biomarker identification;Cell Aging;Cell Culture Techniques;cell type;Cells;Chromium;Complementary DNA;Complex;Cross-Sectional Studies;Data;Development;Disease;disease model;Disease Progression;Elderly;Etoposide;experimental study;Fatty acid glycerol esters;Fatty Liver;Fibroblasts;Foam Cells;functional decline;gain of function;Genetic Transcription;Genomics;Heart;High Fat Diet;Human;Immunologics;In Vitro;in vivo;Individual;Inflammation;Injections;insight;Length;Light;Link;Liver;Low Density Lipoprotein Receptor;male;Maps;Metabolic;Mission;Modeling;Molecular;mouse model;Mus;mutant;nanopore;non-alcoholic fatty liver disease;normal aging;Nucleic Acids;old mice;Organ;Organism;Oxidation-Reduction;Pathway interactions;Proliferating;Proprotein Convertases;Protein Isoforms;Proteome;Protocols documentation;Recombinant adeno-associated virus (rAAV);Regulation;response;Reverse Transcription;Risk Factors;RNA Splicing;Role;Sampling;senescence;single molecule;single-cell RNA sequencing;Subtilisins;Surveys;Suspensions;System;Technology;therapeutic target;Tissues;Transcript;transcriptomics;Variant;WI 38 cell;Work

PROJECT_TITLE: Profiling splicing isoforms in single cells in the atherosclerosis niche


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;aging brain;Alternative Splicing;Alzheimer's Disease;Amino Acid Sequence Databases;Animals;Brain;Brain region;Cells;Cerebral cortex;Chromium;Coupled;Data;Data Set;Encapsulated;Evaluation;Event;Female;Genomics;Heterogeneity;Hippocampus;Intergenic Sequence;Knowledge;Length;male;Mass Spectrum Analysis;Methods;Mus;nanopore;Nerve Degeneration;novel;novel marker;old mice;Peptides;Protein Isoforms;Proteins;proteogenomics;Proteomics;Research Project Grants;RNA;single cell analysis;single cell sequencing;single-cell RNA sequencing;System;Techniques;Transcript;transcriptome;transcriptome sequencing;Validation;Variant;Work;young adult

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT Single Cell Long Read Sequencing of the Aging Mouse Brain


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: 5' Untranslated Regions;Adult;Age;age related neurodegeneration;aging related;Alleles;Amino Acids;Apoptosis;autism spectrum disorder;Base Pairing;behavior change;behavioral study;Binding;Binding Sites;Biological Assay;C9ORF72;Cell Cycle Arrest;Cell Line;Cell model;Cells;circadian pacemaker;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Compensation;Complex;Cytoplasmic Granules;Data;Defect;Development;Diabetes Mellitus;Disease;disease model;Drosophila eye;Drosophila genus;Drosophila inturned protein;Drosophila Proteins;Eye;Eye Development;fly;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;genetic manipulation;Genetic Polymorphism;Genetic study;genetic testing;genome-wide;Glass;Hela Cells;Homologous Gene;Housekeeping;Human;Huntington Disease;Huntington gene;Immunoprecipitation;in vivo;interest;Internal Ribosome Entry Site;Intervention;knock-down;Knock-out;Knockout Mice;Link;Mammalian Cell;Manuscripts;Messenger RNA;Modeling;Molecular;mouse model;mRNA Translation;Mus;mutant;Mutation;Nerve Degeneration;neurodevelopment;Neurons;Nucleotides;Open Reading Frames;Orthologous Gene;overexpression;Pathogenesis;Pathogenicity;Phenotype;Pigments;Plasmids;Play;polyglutamine;protein aggregation;Protein Family;protein function;Proteins;Proteomics;Publishing;Puromycin;Quantitative Reverse Transcriptase PCR;recruit;Regulation;Reiterated Genes;Reporter;Research;ribosome profiling;Ribosomes;RNA;RNA Binding;RNA Interference;RNA-Binding Proteins;Role;Schizophrenia;Stress;stress granule;Temperature;Testing;Tissues;tool;Topoisomerase;transcription factor;transcriptome sequencing;Translational Repression;Translations

PROJECT_TITLE: Investigating the roles of RNA-binding proteins Nocte and PRRC2 in mRNA translation and age-related neurodegeneration using Drosophila and mouse models


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Social Determinants of Health

PI_NAMEs: SEN, PAYEL  (contact)

PROJECT_TERMS: age related;Alzheimer's Disease;Alzheimer's disease related dementia;Antibodies;Binding;Blood;Blood - brain barrier anatomy;blood-based biomarker;Brain;cell age;Cell Count;Cell Nucleus;Cells;Chromatin;Collecting Cell;combinatorial;Computer Analysis;Consumption;Data;Data Set;deep learning;Dementia;design;Diagnosis;DNA Methylation;Drug Targeting;Elderly;Enhancers;Environmental Exposure;epigenetic clock;Epigenetic Process;epigenomics;Excision;experimental study;Future;gene environment interaction;Gene Expression;Genes;Goals;health economics;Health Status;Immunophenotyping;Libraries;Measures;multiple omics;Nerve Degeneration;Neurodegenerative Disorders;neuroprotection;novel;Nuclear;older adult;Organ;Participant;peripheral blood;Peripheral Blood Mononuclear Cell;personalized medicine;Persons;Plasma;Population;Predisposition;Process;promoter;protein aggregation;Protocols documentation;Research;Research Project Grants;RNA;Sampling;single-cell RNA sequencing;socioeconomics;Techniques;Time;Titrations;transcription factor;transcriptomics;XCL1 gene

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT - Predicting Chromatin Signatures of Alzheimers Disease and Related Dementia from Peripheral Blood


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Natural Products;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Age;age related;Alzheimer's Disease;Animals;Anxiety;Aorta;Area;Arterial Fatty Streak;arterial remodeling;arterial stiffness;Arteries;Atherosclerosis;atherosclerosis risk;Behavioral;Blood Vessels;Brain;Brain region;Cell Aging;Cells;Circulation;Coagulation Process;Cognition;Cognitive;Collagen;Complement;Data;Dementia;Disease;Endothelial Cells;Excision;experience;experimental study;Female;Fibroblasts;fisetin;Galactosidase;Hand Strength;Human;Immune;Impaired cognition;improved;Link;male;Mass Spectrum Analysis;Mitochondria;Mus;Necrosis;old mice;Organ;Pathologic;Pathologic Processes;Pathology;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;protein expression;Proteins;remote location;Research Project Grants;Risk Factors;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Smooth Muscle Myocytes;spatial memory;Thick;Tissues;vascular cognitive impairment and dementia;Vascular Diseases;Vascular Smooth Muscle;Wild Type Mouse

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT - Impact of atherosclerosis-induced cellular senescence on vascular cognitive impairment and dementia (VCID) (Alzheimers disease)


PROJECT_TERMS: age-related disease;Animal Model;antibody test;Antibody-drug conjugates;Aorta;Area;Atherosclerosis;Blood Vessels;cadherin 5;Cell Adhesion;Cell Proliferation;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cytokine Receptors;deamidation;Development;Effectiveness;experimental study;Flow Cytometry;Fractionation;Genes;Goals;Human;ICAM1 gene;ICAM2 gene;Immune;improved outcome;KDR gene;Mass Spectrum Analysis;Membrane;Membrane Proteins;Metabolism;mouse model;Mus;Ontology;PECAM1 gene;Peptides;Phase;Proliferating;protein biomarkers;Proteins;Proteome;Receptor Signaling;senescence;senescent cell;senolytics;Sorting;Specificity;Surface;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;tool;transcriptome;Vascular Diseases;Western Blotting

PROJECT_TITLE: Cell Surface Indicators of Vascular Senescence


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

PI_NAMEs: WENG, NAN-PING PETER (contact)

PROJECT_TERMS: 2019-nCoV;Adult;Age;age effect;age related;age related changes;Aging;alpha-beta T-Cell Receptor;antigen-specific T cells;Antigens;Binding;cancer cell;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cellular Immunity;chromatin modification;Clonal Expansion;Complex;Cytomegalovirus;cytotoxic;Disease;Epitopes;Frequencies;Genes;Goals;Helper-Inducer T-Lymphocyte;HLA-A2 Antigen;Human;Human body;Immunity;In Vitro;Individual;Infection;influenzavirus;innate immune function;Measures;Memory;Methods;Mus;novel;Nucleocapsid;older adult;pathogen;Peptides;Play;precision medicine;Predisposition;Proliferating;Proteins;Resolution;response;Role;SARS-CoV-2 infection;single cell sequencing;single-cell RNA sequencing;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Development;T-cell diversity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Thymus Gland;transcriptome;V(D)J Recombination

PROJECT_TITLE: TCR repertoire: size, diversity, and function


PROJECT_TERMS: adult neurogenesis;Affect;age related;age related neurodegeneration;age-related disease;Aging;aging related;aging related disease;Aman;Animal Model;Animals;Antibodies;autism spectrum disorder;Autoimmune Diseases;Autophagocytosis;Binding;biological adaptation to stress;Biological Models;cancer cell;Cell Culture System;Cell Line;Cell model;Cell Physiology;Cells;ChIP-seq;Clinical Trials;Complex;Data;DNA;drivers of aging;Drosophila genus;Eating;Exhibits;Fat Body;fly;Gene Expression;gene repression;Genes;genetic element;Genetic Transcription;Genomics;hallmarks of aging;HCT116 Cells;Health;Hour;Human;improved;Intellectual functioning disability;Knock-in;Larva;life span;Link;LysoTracker;Malignant Neoplasms;Mental disorders;Messenger RNA;Methods;model organism;mouse model;mRNA Translation;Mus;mutant;Mutation;Names;Nature;Nerve Degeneration;Nervous System Disorder;neurodevelopment;Neurons;Nutrient;Organelles;Organism;Paper;Pathway interactions;Premature aging syndrome;prevent;Prevention;Process;Protein Isoforms;Proteins;Publishing;Recycling;Regulation;response;RNA;RNA immunoprecipitation sequencing;Role;Schizophrenia;Signal Transduction;Stains;Starvation;Stress;Testing;therapeutic target;Topoisomerase;Transcription Elongation;transcription factor;transcription factor USF;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Translations;trend;Western Blotting

PROJECT_TITLE: Investigating the roles of a Topoisomerase complex in autophagy and lifespan regulation


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PROJECT_TERMS: 2019-nCoV;Affect;Area;autism spectrum disorder;Autoantibodies;B-Lymphocytes;Bacteria;Bacterial Infections;behavioral impairment;biological adaptation to stress;Blood;Blood Cells;Bone Marrow Cells;Cell Line;Cells;chemokine;Chemotaxis;Clinical Trials;Coagulation Process;Complex;Control Groups;Coronavirus;Coronavirus Infections;COVID-19 patient;COVID-19 treatment;cytokine;cytokine release syndrome;cytotoxic;Data;Diffusion;Disease;DNA;Drosophila genus;Economics;enzyme activity;established cell line;Exhibits;experimental study;extracellular;Family;fly;FMR1 gene;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Harvest;Heterochromatin;Human;Immune response;Immune signaling;Immune system;Immune System Diseases;immunoregulation;Infection;Inflammation;Inflammatory Response;inhibitor;Injury;insight;Knockout Mice;Life;life span;Listeria;Listeria monocytogenes;Lung;Lymphocyte;Macrophage;male;Melanins;melanocyte;Messenger RNA;Modeling;mouse model;mRNA Translation;Murine hepatitis virus;Mus;neural;neurodevelopment;neutrophil;Numerical Chromosomal Abnormality;pathogen;pathogenic bacteria;pathogenic virus;Pharmaceutical Preparations;Phenotype;Pigmentation physiologic function;Pigments;prevent;Recovery;response;RNA;Role;Sampling;SARS coronavirus;Schizophrenia;Serum;Signal Pathway;Site;Small Interfering RNA;Splenocyte;Stimulus;Study models;T-Lymphocyte;Testing;Time;TOP1 gene;Topoisomerase;Topoisomerase Inhibitors;Transcriptional Activation;transcriptome sequencing;Update;Viral;Viral hepatitis;Virus;Work;wound response

PROJECT_TITLE: Investigating roles of Topoisomerase 3b (TOP3B) in immune responses to infection by coronavirus and bacteria


PROJECT_TERMS: Affect;Age;age-related disease;Aging;angiogenesis;Apoptosis;Archives;Attention;biological adaptation to stress;Biological Models;Biological Sciences;cancer cell;carcinogenesis;Cell Cycle;Cell division;cell injury;Cell Proliferation;Cell Survival;Cells;Cellular biology;circular RNA;Clinical;Collaborations;Development;Drosophila genus;Experimental Ophthalmology;Funding;Gene Expression Profile;Genes;Genetic;Goals;HuR protein;Immune Evasion;Impairment;insight;interest;intestinal epithelium;intestinal homeostasis;Invaded;Link;Liver diseases;Macular degeneration;Malignant Neoplasms;Mammalian Cell;Messenger RNA;Mitogens;Mitosis;Names;Nature;Neoplasm Metastasis;Nucleic Acids;Open Reading Frames;Post-Transcriptional Regulation;posttranscriptional;Process;Proliferating;Proteins;Reporting;response;RNA;RNA-Binding Proteins;Role;Signal Transduction;Stress;Sumoylation Pathway;Tissues;trait;Untranslated RNA

PROJECT_TITLE: Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Infectious Diseases;Mental Health;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: EVANS, MICHELE K (contact)

PROJECT_TERMS: accelerated epigenetic aging;Address;African American;African American population;Age;age difference;Age Distribution;age related;Age Years;American;Area;Automobile Driving;Baltimore;Behavioral;Binding;Biocompatible Materials;Biological;Biological Factors;Biological Markers;Biology;Blood Chemical Analysis;Blood Vessels;Body Composition;Bone Density;bone quality;brain health;Brain imaging;Cardiovascular Diseases;Censuses;Characteristics;Cities;Clinical;Clinical Research;cofactor;Cognition;Cognitive;cohort;Collection;Communities;Complex;COVID-19 pandemic;COVID-19 testing;Data;demographics;depressive symptoms;design;Development;dietary;Discrimination;Disease;DNA;DNA Methylation;DNA Repair;endothelial dysfunction;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;Evaluation;executive function;extracellular vesicles;Failure;financial literacy;follow-up;frailty;Gender;Genetic;Genomics;Guidelines;Health;health care quality;health disparity;health equality;health literacy;health outcome disparity;health service use;Health Services;Health Status;healthy aging;heart rate variability;Hematology;Home;Home visitation;Household;Housing;Human;Image;Impaired cognition;improved;Incidence;Income;Individual;International;Interview;Laboratories;life span;literacy;Literature;Longevity;Longitudinal Studies;low socioeconomic status;Measurement;Measures;medical examination;Medical History;Medical Research;Methodology;Methods;microbiome;Minority;Molecular;molecular marker;Morbidity - disease rate;mortality;multidisciplinary;muscle strength;Neighborhoods;Neuroanatomy;new pandemic;novel;nutrition;Occupations;Optical Coherence Tomography;Outcome;oxidative damage;pandemic impact;Participant;Pathway interactions;Physical Examination;Physical Function;Physical Performance;Poverty;pre-clinical;Prevalence;prevent;Probability;Probability Samples;prospective;Prospective cohort;Protocols documentation;Proxy;Psychology;Psychophysiology;psychosocial;Psychosocial Factor;Questionnaires;Race;racial difference;racism;Recording of previous events;recruit;Renal function;Reporting;Research;Research Design;Risk;Risk Factors;Role;Sample Size;Sampling;SARS-CoV-2 infection;screening;Sensory;Seroprevalences;Services;sex;Short Waves;Site;Smell Perception;social;social capital;social cohesion;social genomics;Societies;sociodemographics;Socioeconomic Status;socioeconomics;Surveys;systemic inflammatory response;telomere;Testing;Thick;Time;tool;transcriptomics;Translational Research;Treatment/Psychosocial Effects;Ultrasonography;Vision;Visit;Weight;Work

PROJECT_TITLE: Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)