NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Physical Activity;Prevention;Primary Health Care;Serious Mental Illness;Sleep Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Current evidence-based practices for adolescent depression, such as standard cognitive behavioral therapy, are time and resource intensive while still leaving some adolescent depression symptoms, including sleep disturbance and fatigue, unresolved. This study will develop and pilot test a just-in-time adaptive intervention (JITAI) for adolescents seeking depression treatment in primary care, a critical setting for reaching adolescents in need of mental health care. JITAIs are a novel technology-based approach that have the potential to increase the effectiveness of depression care by utilizing in-the-moment smartphone and wearable device data to identify vulnerable periods (e.g., periods of inactivity, poor sleep health) and provide timely, targeted interventions when they are most needed for a particular adolescent.

PI_NAMEs: JENNESS, JESSICA LYNNE (contact);MILLER, ADAM BRYANT

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: adaptive intervention;Adolescent;adolescent mental health;Age;algorithm development;Algorithms;arm;Caring;Cellular Phone;child depression;Chronic;Clinical;Clinical Trials;Cognitive Therapy;collaborative care;Data;data streams;depressive symptoms;design;Development;Diagnosis;digital;digital delivery;digital platform;digital tool;disability;Distal;Ecological momentary assessment;Effectiveness;evidence base;Evidence based intervention;Evidence based practice;executive function;exercise intervention;experience;Fatigue;functional outcomes;human centered design;Hypersomnias;implementation evaluation;implementation measures;implementation outcomes;improved;improvement on sleep;inattention;Individual;innovation;Intervention;intervention refinement;Interview;Learning;Major Depressive Disorder;Measurement;Measures;Medical;member;Mental Depression;Mental Health;Mental Health Services;Monitor;Moods;new technology;Notification;Outcome;Outpatients;Participant;Patient Self-Report;Patients;Pattern;Persons;Phase;Physical activity;Pilot Projects;pilot test;poor sleep;prediction algorithm;Primary Care;Procedures;Process;psychosocial;Randomized;randomized trial;Randomized, Controlled Trials;Research;Resources;Risk;sedentary lifestyle;Series;skills;Sleep;Sleep disturbances;sleep health;Sleeplessness;smart watch;smartphone based device;suicidal;suicidal morbidity;Surveys;Symptoms;Technology;Testing;Time;tool;Treatment outcome;usability;wearable data;wearable device;Youth

PROJECT_TITLE: Developing a Digital Just-in-Time Adaptive Intervention for Adolescent Depression Treatment in Primary Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (06)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Microbiome;Nutrition;Obesity;Pneumonia and Influenza;Prevention

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Obesity, a systemic disorder of metabolism, is associated with chronic inflammation and impaired immune cell responses to infection from select viruses, such as influenza and SARS-CoV-2. Interestingly, weight loss achieved by continuous low-fat diet does not improve obesity-associated inflammation or improve survival to influenza infection; therefore, alternative approaches to improve immune responses to viral infection in individuals with obesity are needed. The objective of this innovative R21 proposal is to test if time-restricted feeding can improve immune response to infection in this high-risk population and identify metabolic and microbiome-related mechanisms by which this may occur.

PI_NAMEs: MACIVER, NANCIE  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 16S ribosomal RNA sequencing;2019-nCoV;Adipose tissue;Animals;Antibody titer measurement;Bacterial Infections;Body Weight decreased;Caloric Restriction;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular Metabolic Process;Chronic;cohort;Coronavirus;dietary approach;Dietary Intervention;DNA;Dose;Fasting;Fat-Restricted Diet;fecal transplantation;Functional disorder;Glucose;glucose uptake;gut microbiome;Health;healthy weight;High Prevalence;high risk population;Human;Immune;Immune response;Immunity;immunoregulation;Impairment;improved;indexing;Individual;Infection;Inflammation;Influenza;influenza infection;innovation;Intermittent fasting;Link;Measures;Mediating;Memory;Metabolic;Metabolic Diseases;metabolic phenotype;metabolic profile;microbiome;microbiome alteration;Mitochondria;Monitor;Morbidity - disease rate;mortality;Mus;novel strategies;Obese Mice;Obesity;Outcome;oxidation;pandemic influenza;Publications;Pulmonary Pathology;Pyruvate;response;Role;seasonal influenza;Stains;System;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Thinness;Time-restricted feeding;transcriptome sequencing;Vaccination;Variant;Viral Load result;Virus;Virus Diseases

PROJECT_TITLE: Utilizing alternative dietary interventions to alter gut microbiome and improve T cell responses to viral infection in obesity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Narrative Accurately assessing obstructive sleep apnea (OSA) severity is essential to improving patient care. In this proposal, we will develop a mathematical model to provide a detailed clinical representation of OSA at various target locations in the body, which will allow for the assessment of tissue hypoxia burden and daytime sleepiness as a potential alternative indicator of severity. The clinically deployable model and resulting pool of data, which will be obtained from simulated cases of OSA and a re-analysis of existing polysomnography studies, will be invaluable to furthering the clinical understanding of OSA.

PI_NAMEs: GROSBERG, ANNA  (contact);KHAYAT, RAMI N

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Affect;aging population;Apnea;Blood gas;Brain;Breathing;Carbon Dioxide;Cardiovascular Diseases;cardiovascular effects;Characteristics;Clinical;clinical application;Clinical Data;Clinical Research;Data;Data Pooling;Data Set;Development;Diagnosis;Disease;Drowsiness;Equation;Evaluation;Health;Heart;Heart Rate;Hemoglobin;Hypercapnia;Hypertension;Hypoxia;Impaired cognition;improved;indexing;Link;Literature;Location;lung volume;mathematical model;Measurement;Measures;Methods;middle age;Modeling;Movement;novel;Obstructive Sleep Apnea;Outcome;Output;Oxygen;oxygen transport;Patient Care;Patients;Pattern;Physiological;Play;Polysomnography;primary outcome;Property;Pulmonary alveolar structure;Pulse Oximetry;Recording of previous events;respiratory;Rest;Risk Assessment;Role;Running;Severities;Sleep;Sleep Apnea Syndromes;Structure;Testing;tissue oxygenation;Tissues;tool;Validation;Venous

PROJECT_TITLE: A novel tool to quantify hypoxia burden from clinical sleep studies

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Streptococcus mutans is the primary causative agent of dental caries, which affects a vast majority of American adults, and the pathogen’s ability to overcome acid stress is key to cariogenicity. The proposed project will define small RNAs (an important class of gene regulators) involved in acid stress response in S. mutans. The new insights gained from this project are expected to contribute to the development of novel approaches that target sRNA regulatory networks to control dental caries.

PI_NAMEs: RAGHAVAN, RAHUL  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 5' Untranslated Regions;acid stress;Acidity;Acids;Adult;Affect;American;Bacteria;Binding;Biochemical;Biochemical Pathway;Biochemical Process;biological adaptation to stress;Biological Assay;Carbohydrates;Catalogs;Consumption;crosslink;Data;dental agent;Dental caries;Development;Elements;Etiology;Exposure to;Fermentation;Foundations;Funding;Gene Expression;Genetic;genetic approach;Genome;Goals;Growth;in vivo;insight;Knowledge;lactic acid bacteria;Messenger RNA;Modeling;Molecular;mutant;novel;novel strategies;Oral;oral bacteria;Outcome;pathogen;Pathogenicity;Pathway interactions;Persons;Phase;Physiological;Play;Post-Transcriptional Regulation;prevent;Process;Proteins;Protocols documentation;Regulator Genes;Research;Resistance;response;RNA;RNA Stability;Role;Small RNA;Streptococcus mutans;Stress;Testing;therapeutic target;Translations;Untranslated RNA;Virulence;Work

PROJECT_TITLE: Role of small RNAs in Streptococcus mutans acid stress response

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: MORGANTOWN

ORG_DEPT: CHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative This proposal addresses the compelling need for new strategies to customize the glycosylation of biological standards. Enabling technology that overcomes current limitations in the field will allow scientists to create biomolecules in support of research on human health.

PI_NAMEs: HOLLAND, LISA A (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Microscale Enzymatic Remodeling of Molecular Glycosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Kidney Disease;Lupus;Microbiome

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Our understanding is limited regarding what triggers serious disease flares in patients with Systemic Lupus Erythematosus (SLE), a condition responsible for major disability and premature death, which disproportionately affects women, under-represented minorities and the economically disadvantaged. From studies of the microbial communities that reside in the gut of SLE patients, paired with blood RNA-seq libraries in these patients, we identified patients with Lupus Nephritis (LN), often the most severe and unpredictable form of disease, who have intestinal expansions of a specific pathobiont, that correlated with activation of platelets, the sentinels of the immune system. These exploratory R21 studies will break new ground and contribute fundamental knowledge on the mechanistic interconnections between the microbiome and autoimmune pathogenesis, as we test hypotheses that gut dysbiosis leads to platelet-mediated thromboinflammatory pathways, which then contribute to the pathogenesis of SLE, especially in LN.

PI_NAMEs: SILVERMAN, GREGG JOSHUA (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Antigen-Antibody Complex;Arthritis;Autoimmune Diseases;autoimmune pathogenesis;Blood;Blood Platelets;Cardiovascular Diseases;Cell membrane;Cells;Cessation of life;Chronic;Circulation;Clinical;Coculture Techniques;cohort;Data;Data Set;Databases;Development;Diagnosis;disability;Disabling;Disease;Disproportionately impacts women;dysbiosis;economic disparity;end stage disease;Exanthema;Exposure to;Feasibility Studies;Flare;Future;genetic manipulation;gut dysbiosis;gut microbiome;gut microbiota;Human;human model;Immune;immune activation;Immune system;Immunologic Receptors;Immunologic Surveillance;immunothrombosis;Impairment;In Vitro;in vitro Assay;in vitro testing;in vivo;in vivo evaluation;Incidence;Individual;individual patient;Infection;Inflammatory;Inflammatory Response;Inherited;Injury to Kidney;Interferons;intestinal barrier;Intestinal permeability;Intestines;Kidney Diseases;Knowledge;Lead;Libraries;Longitudinal Studies;low socioeconomic status;Lupus;Lupus Nephritis;lupus prone mice;Mediating;Megakaryocytes;member;microbial;microbial community;microbiome;microbiome composition;Molecular;monocyte;Morbidity - disease rate;mouse model;multidisciplinary;Mus;neutrophil;New Agents;novel;pathobiont;Pathogenesis;Pathogenicity;Pathway interactions;Patient Representative;patient subsets;Patients;Pattern;Phase;Phenotype;Platelet Activation;Play;premature;randomized, clinical trials;receptor;Reporter Genes;Research;Risk Factors;Role;Ruminococcus;Sampling;Sentinel;Sepsis;Stimulant;surveillance study;Surveys;System;systemic autoimmune disease;Systemic Lupus Erythematosus;Testing;thromboinflammation;Time;tissue injury;Transcript;transcriptome sequencing;transcriptomics;Transgenes;type I interferon receptor;Underrepresented Minority;Whole Blood;Work

PROJECT_TITLE: Thromboinflammatory pathways triggered by gut dysbiosis in patients with Lupus

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Regeneration of neural circuits requires extension of axons by transplanted neurons and reestablishment of proper synaptic connections onto target neurons. This proposal is focused on understanding the molecular changes that occur within human photoreceptors (PRs) that may be responsible for age-dependent loss of autonomous axon extension. By genetically modifying human PRs, we hope to improve the ability of transplanted PRs to reintegrate into existing circuits within an injured adult retina.

PI_NAMEs: GOMEZ, TIMOTHY M (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Actins;Adult;Age;age related;Age related macular degeneration;Axon;axon regeneration;Bioinformatics;cell motility;cell replacement therapy;Cells;Clinical;Collaborations;Complex;Cytoskeleton;Data Analyses;Development;Embryo;experimental study;F-Actin;gain of function;Gene Modified;Genes;genetic regulatory protein;Growth Cones;Human;human stem cell-derived;Immobilization;improved;Individual;injured;innovation;interest;Internet;Label;Letters;loss of function;Mass Spectrum Analysis;Methods;Microfilaments;Molecular;Motility;mutation correction;Natural regeneration;Nerve Regeneration;neural circuit;Neurons;Operative Surgical Procedures;Ophthalmologist;Organoids;Pathway interactions;Phase;Photoreceptors;Polymers;Postoperative Period;Process;professor;protein expression;Protein Overexpression;Proteins;Proteomics;restoration;Retina;Retinal Diseases;Series;stem cells;Structure of retinal pigment epithelium;success;Synapses;Testing;Time;Transplantation;transplantation therapy;Up-Regulation;Virus

PROJECT_TITLE: Restoring cytoskeletal dynamics to improve circuit integration of transplanted photoreceptors

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative A hall mark feature of heart failure (HF) is the consistent loss of beta-adrenergic receptor (βAR) function which is responsible for increasing cardiac contraction. There are no drugs that reverses or normalizes the loss of βAR function, as current treatment options only delay the progression of heart failure. Our studies have identified small molecules that restores βAR function and could be suitable for drug development studies to therapeutically target a novel pathway in heart failure.

PI_NAMEs: JOSYULA, VARA PRASAD VN;PRASAD, SATHYAMANGLA V (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Adenylate Cyclase;Adult;aging population;Agonist;analog;aorta constriction;Applications Grants;arm;Attenuated;attenuation;Back;beta-adrenergic receptor;beta-arrestin;Binding;Biochemical;Biological Assay;Biological Availability;Calcium;Cardiac;Cardiac Output;Cardiotoxicity;Cell membrane;Cell surface;Cells;Clinical;Complex;Cyclic AMP;Data;desensitization;design;Diabetes Mellitus;Docking;drug development;Drug Interactions;Endocytosis;Endosomes;Epidemic;Epinephrine;Etiology;Evaluation;Functional disorder;functional restoration;Funding Opportunities;G protein coupled receptor kinase;Generations;Goals;Grant;Heart;Heart failure;heart function;heart preservation;Hormones;Human;Hypertension;Hypoxia;Impairment;improved;in silico;In Vitro;in vitro activity;in vivo;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;ischemic cardiomyopathy;Lead;lead candidate;Left;Literature;Lung;Maintenance;Malignant Neoplasms;Measures;Mediating;Metabolic;Modeling;Modification;Molecular Conformation;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial dysfunction;Myocardial Infarction;Norepinephrine;novel;novel therapeutics;Oral;Outcome;Oxygen;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacophore;Phase;phosphatase inhibitor;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;pre-IND studies;preservation;product development;Property;Protein Dephosphorylation;Protein phosphatase;Pulmonary Hypertension;Rattus;Recycling;Regulation;response;right ventricular failure;Role;Sampling;secondary outcome;Seminal;SET gene;small molecule;small molecule therapeutics;stroke outcome;Structure;Testing;Therapeutic;therapeutic target;tool;Toxic effect;Transgenic Mice;Translating;United States National Institutes of Health;Ventricular;Work

PROJECT_TITLE: Small Molecule Therapeutic for Heart Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O2)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Regenerative Medicine;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Breast reconstruction is becoming an area where reconstructive surgery intersects with regenerative medicine as autologous fat grafting is rapidly evolving to include engineered tissue grafts. However, the tools to quantitatively follow these tissues over time is limited by cost, convenience, consistency and clinical applicability, particularly during the engraftment process. The purpose of this multi-disciplinary mixed methods approach is to develop a novel 3D imaging framework to assess volume and surface characteristics in oncologic breast reconstruction with autologous fat grafting and demonstrate feasibility in an outpatient clinical setting.

PI_NAMEs: HANSON, SUMMER E (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;adipose derived stem cell;Adipose tissue;Adoption;Algorithmic Analysis;Area;Assessment tool;Atrophic;Autologous;Biological;Body part;Breast;Breast Cancer Treatment;Canada;Cancer Patient;cancer therapy;Cells;Characteristics;Cicatrix;clay;Clinic;Clinical;clinical application;Clinical assessments;clinical translation;cohort;Consumption;Contracture;cost;Counseling;Cyst;cytokine;Defect;Deformity;design;Development;Dimensions;Engineering;Engraftment;Esthetics;fat grafting;Fat necrosis;Fatty acid glycerol esters;Feasibility Studies;Fibrosis;Funding;Future;Geometry;Goals;Growth Factor;healing;Image;Image Analysis;Imaging Device;imaging platform;Immune;Implant;improved;Inflammation;innovation;Literature;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammaplasty;Mammary Gland Parenchyma;Mammography;Measurement;Measures;Methods;Monitor;multidisciplinary;novel;novel strategies;Operative Surgical Procedures;Outcome;Outpatients;Pain;Participant;Patients;Performance;Physicians;Pilot Projects;portability;predictive modeling;Procedures;Process;quantitative imaging;Radiation Fibrosis;Radiation therapy;randomized, clinical trials;reconstruction;Reconstructive Surgical Procedures;recruit;Regenerative Medicine;Reporting;Research;Resolution;retention rate;Risk;Safety;satisfaction;scaffold;Scanning;serial imaging;Shapes;Site;soft tissue;stem cells;Suction Lipectomy;Surface;targeted treatment;Techniques;Testing;Three-Dimensional Imaging;Time;Tissue Engineering;Tissue Grafts;tissue reconstruction;tissue regeneration;tissue repair;Tissues;tool;Ultrasonography;ultrasound;Uncertainty;Visit

PROJECT_TITLE: Quantitative assessment of autologous fat grafting in breast cancer treatment using 3D imaging

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

PHR: Narrative B cells are key cells of the immune system responsible for producing antibodies, but current technologies is not yet able to control antibody production by B cells with genetic precision. Here, we seek to engineer viral gene vectors that allow us to directly reprogram B cells in vivo, enabling us to precisely control what antibody is to be secreted. If successful, our work may lead to a new approach in engineering immunity as well as sustaining protein-based therapies for a wide range of diseases.

PI_NAMEs: LAI, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Ablation;Adjuvant;Affinity;Animals;Antibodies;Antibody Formation;Antibody Response;Antigen Presentation;Antigens;Avidity;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Bypass;Cell fusion;Cell Maturation;Cell Reprogramming;Cell secretion;Cell-Matrix Junction;Cells;cellular engineering;chimeric antibody;Chimeric Proteins;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complementarity Determining Regions;Coupled;CRISPR/Cas technology;design;Disease;DNA;DNA delivery;Dose;Endosomes;Engineering;Enhancers;Ensure;Fab domain;FDA approved;Generations;Genetic;GTP-Binding Proteins;Human;Immune;Immune system;Immunity;immunodeficiency;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;improved;in vivo;Individual;Infant;Infection;Injections;interest;Lead;Length;lentivirally transduced;Lentivirus;Lentivirus Vector;Light;Lymphocyte;Lymphoma;Measles;Membrane;Membrane Fusion;Methods;Molecular;MS4A1 gene;Mus;Mutation;Nature;neutralizing antibody;neutralizing monoclonal antibodies;Nipah;Nipah Virus;novel strategies;Passive Immunization;pathogen;Peripheral Blood Mononuclear Cell;Pilot Projects;Plasma Cells;Population;Process;Production;programs;Proteins;prototype;Pulmonary Pathology;Reaction;receptor binding;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Safety;Serum;Site;site-specific integration;Specificity;synthetic biology;System;T-Lymphocyte;Technology;Testing;Therapeutic antibodies;therapeutic protein;Time;transduction efficiency;transgene delivery;Transgenes;Tropism;tumor;Tumor Suppression;Vaccination;vaccine development;Vaccines;Variant;vector;Vesicular stomatitis Indiana virus;Viral;Viral Genes;Virus;Vision;Work

PROJECT_TITLE: In vivo engineering of chimeric antibody reprogrammed (CAR) B cells with fully tunable antibody response

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE: Understanding how our genes affect the behavior of individual cells is a fundamental question in many scientific fields ranging from human genetics to developmental biology to cancer biology. In this technology development grant, we will seek to vastly improve how to detect the identify of DNA variants while simultaneously determining their effects on RNA within the same cells. We hope this technology will facilitate more rapid discovery of the effects of genetic variants and cancer mutations to improve our understanding of the human condition and disease conditions.

PI_NAMEs: HIGGINSON, DANIEL  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adopted;Affect;Alleles;Area;Bar Codes;base editing;Basic Science;Behavior;Cancer Biology;cancer cell;carcinogenesis;Cell Differentiation process;Cell Separation;cell type;Cells;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Complex Mixtures;Detection;Development;Developmental Biology;Disease;DNA;DNA amplification;DNA sequencing;Evaluation;experimental study;Fathers;Frequencies;Gene Frequency;Genes;Genetic Polymorphism;Genetic Recombination;genetic variant;Genome;genomic locus;genomic platform;Genomics;Genotype;Grant;Heterozygote;Human;Human Genetics;improved;Individual;Industry Standard;insertion/deletion mutation;Investigation;isothermal amplification;Joints;Laboratories;Libraries;Malignant Neoplasms;melting;Messenger RNA;Methodology;Methods;Modeling;Mosaicism;Mothers;multiple omics;Mutation;Mutation Detection;Names;Organism;Paper;Performance;Phenotype;physical separation;Polymerase;polymerization;Polymers;Population;Preparation;prospective;Protocols documentation;recombinase;Research;Reverse Transcription;RNA;RNA library;Sampling;Science;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Specimen;System;targeted sequencing;Techniques;Technology;technology development;Temperature;Testing;tool;transcriptome;transcriptome sequencing;Translational Research;tumor;Variant

PROJECT_TITLE: Recombinase polymerase amplification to enable same-cell, DNA/RNA multi-omic single cell sequencing

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the proposed gaze-controlled neck exoskeleton and its associated personalization strategy have the potential to improve care and quality of life for people with dropped head syndrome, a condition caused by diverse diseases such as neurological disorders and autoim- mune conditions. This project is relevant to the part of the NIBIB’s mission that pertains to developing biomedical technologies to improve health and medical care.

PI_NAMEs: BROWN, DANIEL SUNDQUIST;ZHANG, HAOHAN  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Adult;Algorithms;Amyotrophic Lateral Sclerosis;Autoimmune Diseases;Behavior;Biomedical Technology;Breathing;Caring;Chest;Clinical Trials;Cross-Over Studies;Data;Data Set;Deformity;Deglutition;Development;Disease;Drops;Effectiveness;evidence base;exoskeleton;Eye;Eye Movements;Fatigue;Feedback;Future;gaze;Goals;handheld equipment;Head;Head and neck structure;Head Movements;Health;Home;human-in-the-loop;human-robot interaction;improved;Individual;innovation;Intuition;invention;Joystick;Knowledge;Laboratories;Learning;Literature;machine learning model;Medical;Minor;Mission;Modeling;Motion;Movement;Muscle Weakness;National Institute of Biomedical Imaging and Bioengineering;Neck;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurological pathology;orbit muscle;Outcome;Pain;Parkinson Disease;Participant;Patients;Pattern;Peripheral;personalized strategies;Persons;Polymyositis;Posture;predictive modeling;preference;Public Health;Publishing;Quality of life;Randomized;Research;Respiratory physiology;robot exoskeleton;Saccades;Scheme;Skeletal muscle structure of neck;Smooth Pursuit;Social Interaction;Spinal;Syndrome;Target Populations;Technology;Testing;Time;Translating;Translational trial;usability;Validation;virtual environment;virtual reality headset;Well in self;Work

PROJECT_TITLE: A gaze-controlled neck exoskeleton for dropped head syndrome

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Digestive Diseases;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE  Down syndrome (DS), or Trisomy 21, is the most frequent chromosomal abnormality in humans, resulting from a complete or partial extra copy of chromosome 21. Children and adults with DS have a higher likelihood of gastrointestinal disorders affecting quality of life. This proposal addresses critical gaps in our knowledge on GI smooth muscle dysfunction in Down syndrome.

PI_NAMEs: AKBARALI, HAMID I (contact);GEORGE, ANDREW ANTHONY

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Acetylcholine;Address;Adolescence;Adolescent;Adult;Affect;aged;Amyloid deposition;Aneuploidy;autosome;Back;Biological Assay;biophysical properties;Birth;Brain;Calcium;Calcium Channel;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Child;Childhood;cholinergic;Chromosome 21;Chromosome abnormality;Clinical;Closure by clamp;Cognitive;Colon;Congenital Megacolon;Constipation;Defect;Development;Developmental Delay Disorders;Disease;Distal;Down's Syndrome;Down-Regulation;electrical property;Electrophysiology (science);Enteral;Enteric Nervous System;Family;Female;Functional disorder;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal tract structure;Genetic;Human;improved;In Vitro;Individual;Interstitial Cell of Cajal;Intervention;Intestines;Investigation;Irritable Bowel Syndrome;Isometric Exercise;Karyotype;Knowledge;Learning;Live Birth;Longevity;male;Measures;Mediating;Memory impairment;Mental disability;migration;Mitochondria;Modeling;Motility;motility disorder;mouse model;mouse Ts65Dn;multidisciplinary;Mus;Muscle;Muscle function;Muscle hypotonia;Muscle Tonus;myelination;Neck;nerve supply;Neural Crest;neurodevelopment;neuronal excitability;Neurons;neuropathology;Neurotransmitters;Nose;Oxidative Stress;Pathway interactions;Patients;Persons;pharmacologic;Physiological;Population;Property;Quality of life;Reporting;Research;response;Rome;Senile Plaques;Skin;Smooth Muscle;Smooth Muscle Myocytes;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Trisomy;Validation;voltage;voltage clamp;young adult

PROJECT_TITLE: Gastrointestinal Dysfunction in Down Syndrome

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Dietary Supplements;Genetics;Human Genome;Neurosciences;Nutrition;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Brain tumors have surpassed the leukemias as the leading cause of cancer-related death in children. Therapeutic options for pediatric brain cancers have shown little expansion over the past few decades and the prognosis for many tumor types (especially Diffuse Midline Gliomas) remains bleak. The research proposed here will examine the utility of dietary fatty acids in halting the growth of Diffuse Midline Gliomas.

PI_NAMEs: DANIAL, NIKA N (contact);FILBIN, MARIELLA GRUBER

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;antitumor effect;Architecture;Astrocytes;ATAC-seq;Biochemical;Biological Assay;Biology;Brain;Brain Neoplasms;Brain Stem;Cancer Etiology;Carcinogenicity Tests;Cell Fate Control;Cell Lineage;Cells;chemotherapy;Child;Child Care;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Malignant Brain Tumor;Chromatin;chromatin remodeling;clinical care;Complement;Complex;Credentialing;CRISPR/Cas technology;Custom;Data;Development;Diet;dietary;Dietary Fats;Dietary Fatty Acid;diffuse midline glioma;efficacy evaluation;Epigenetic Process;Fatty Acid Desaturases;fatty acid supplementation;gain of function;Genetic;Glial Differentiation;Glioma;Gliomagenesis;Growth;histone methyltransferase;Histones;Implant;in vivo;leukemia;Link;Lipids;loss of function;Malignant - descriptor;Malignant neoplasm of brain;Maps;Mediating;Metabolic;Metabolism;metabolomics;Methylation;Molecular;Mus;neoplastic cell;Neuroglia;Neurosphere;novel;Nutrient;oncohistone;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Patients;PDGFRA gene;pharmacologic;Polycomb;Polyunsaturated Fatty Acids;Pontine structure;Population;Pre-Clinical Model;progenitor;Prognosis;programs;Refractory;Regulation;Research;Role;Scientist;self-renewal;Serum;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cell differentiation;stem cell expansion;stem cell population;stem cells;Supplementation;Testing;Therapeutic;transcriptomics;tumor;tumor growth;tumorigenic

PROJECT_TITLE: Mechanism and functional consequences of dietary lipids in lineage specification and tumor growth in oncohistone gliomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-B (O1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: NARRATIVE. Delivery of siRNA or drug-carrying nanoparticles into the central nervous system by peripheral injection is possible with use of cell penetrating peptides (CPP), however current CPPs are not selective for specific cellular macromolecules limiting their use. This application will determine for the first time if a novel cell penetrating peptide can deliver siRNA into cells and the mouse brain by a specific nicotinic receptor subtype. By addressing these critical gaps in our knowledge, this research will 1) determine the cargo delivery potential of the novel CPP furthering the development of our novel agent as a research tool or potential therapy, and 2) provide key preliminary data for future NIH R01 applications.

PI_NAMEs: WELTZIN, MAEGAN M (contact)

PROGRAM_OFFICER_NAME: MICHELOTTI, ENRIQUE

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Affect;Alpha Cell;alpha-bungarotoxin receptor;antagonist;Apoptosis;Behavior;Biological Assay;blood-brain barrier crossing;Brain;Brain imaging;brain tissue;Brain-Derived Neurotrophic Factor;burden of illness;Cell Culture Techniques;Cell Line;Cells;Central Nervous System;cholinergic;Clinical;combat;Complex;Confocal Microscopy;Coupled;Cultured Cells;Data;depressive symptoms;desensitization;design;Development;Dose;drug development;drug discovery;Embryo;Enzyme-Linked Immunosorbent Assay;Epilepsy;experience;Feasibility Studies;Female;First Generation College Students;Fluorescein;fluorophore;Funding;Future;Generations;Goals;graduate student;hands on research;Harvest;Health;Hispanic Populations;Human;Image;improved;in vivo;Individual;inhibitor;inhibitor therapy;Injections;Ion Channel Gating;Kidney;Knowledge;Laboratories;Lead;Ligands;Lipid Bilayers;Location;macromolecule;Major Depressive Disorder;member;Mental Depression;Mental disorders;Mission;Mus;nanoparticle;National Institute of Mental Health;Native Americans;Nervous System Disorder;Neuroblastoma;Neurons;Neurotransmitters;Nicotine Dependence;Nicotinic Receptors;Norepinephrine;novel;Organ;Outcome;Penetration;Peptides;Peripheral;Peripheral Nervous System;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pilot Projects;Positioning Attribute;Prevalence;Process;Production;protein expression;Proteins;Psyche structure;Publications;Research;research and development;Research Methodology;Research Personnel;Research Support;reuptake;RNA Degradation;Science;Serotonin;side effect;siRNA delivery;Small Interfering RNA;Strategic Planning;success;System;Technology;Therapeutic;Time;timeline;Tissues;tool;Translations;treatment strategy;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Nicotinic receptor selective cell penetrating peptide for brain cargo delivery

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative This project will address whether the proliferation of health insurance plans with high deductibles is exacerbating income-related disparities in healthcare access. While these plans are well-known to reduce spending by reducing use of medical services, questions remain about which types of health care services enrollees forego and how these plans impact individuals across levels of household income. I assess changes in spending and service use among individuals who move from traditional to high-deductible health insurance plans, and compare these changes across household income, to inform health policy discussions about whether high deductibles reduce health spending without harming population health.

PI_NAMEs: CLIFF, ELIZABETH QUERNA (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Algorithms;American;Area;Award;Caring;Censuses;Chronic;Chronic Disease;Clinical;Code;Colorado;Communities;comparison group;Contracts;cost;Coupled;Data;Data Analyses;Data Set;Databases;Deductibles;Diagnostic;Disease;Disparity;Elasticity;Employment;Enrollment;Future;Geography;Goals;Growth;Health;health care availability;health care disparity;health care service;health care service utilization;health disparity;Health Insurance;health plan;Health Policy;health service use;Health Services Accessibility;Healthcare;high risk;High-Income Populations;Household;Income;Income Distributions;Individual;individual response;Insurance;Insurance Coverage;Intervention;Link;Literature;Location;Low income;Low Income Population;Measures;Medical;Metadata;Methods;mortality;Neighborhoods;Outcome;Outcome Measure;Patients;Persons;Pharmacologic Substance;Policies;Policy Maker;Population;population health;prevent;Price;Procedures;Proliferating;Protocols documentation;Public Health;Quasi-experiment;Reproducibility;Research;Research Design;residence;Resources;response;Risk;Role;Running;service utilization;Services;Subgroup;tool;trend;Uninsured Medical Expense;United States;Variant;Work

PROJECT_TITLE: Impact of High-Deductible Health Plan Enrollment on Health Spending and Utilization: Comparisons by Income

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-5 (01)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Wound Healing and Care

ORG_CITY: MERCED

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE Patients with critical limb ischemia (CLI) patients continue to suffer from severely reduced quality of life and high mortality rates with revascularization remaining an important first line of treatment. Clinical trials of revascularization procedures and medical therapies, like angioplasty or bypass surgery, are associated with some improvement in subsequent amputation-free survival by about 6 months, but the quality of life assessments remain extremely low compared with normal population values. The proposed studies will deliver tip-specific endothelial cells (ECs) derived from pluripotent stem cells to direct the growth of new blood vessels in murine ischemic hind limbs to address this unmet need for patients with CLI.

PI_NAMEs: HUANG, NGAN F.;MCCLOSKEY, KARA E (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Age;alternative treatment;Amputation;Angioplasty;Animal Model;Behavior;Biocompatible Materials;Biological Assay;bioscaffold;Blood Vessels;Bone Marrow;Bypass;Cardiovascular Diseases;Cell Count;Cell Differentiation process;Cell Reprogramming;Cell Survival;Cell Therapy;cell type;Cells;chronic ulcer;Clinical Trials;Collagen;collagen scaffold;controlled release;critical limb Ischemia;Death Rate;Endothelial Cells;endothelial stem cell;Exhibits;Fibrin;Gangrene;Gel;Gene Expression Profile;Generations;Growth;Health;high risk;Hindlimb;hospital readmission;Hospitalization;Human;human induced pluripotent stem cells;human stem cells;implantation;improved;In Situ;In Vitro;in vivo;induced pluripotent stem cell;Injections;innovation;Invaded;Investigation;Ischemia;Laboratories;Lead;limb ischemia;Limb structure;Maintenance;Medical;Mesenchymal Stem Cells;Mononuclear;Morbidity - disease rate;mortality;Mouse Embryonic Stem Cells;mouse model;mRNA delivery;Mus;Muscle;Myocardial Ischemia;nanopattern;new growth;Operative Surgical Procedures;Organ;Pain;Patients;Pattern;PECAM1 gene;Perfusion;Peripheral arterial disease;peripheral blood;PGF gene;Phalanx;Phenotype;Pluripotent Stem Cells;Population;Positioning Attribute;Pre-Clinical Model;Prevalence;Procedures;Quality of life;Quality of Life Assessment;Reproducibility;response;Rest;revascularization;scale up;Signal Transduction;Source;stem cell population;stem cells;success;Supporting Cell;therapeutically effective;Tissues;Transplantation;treatment strategy;United States;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factor Receptor-3

PROJECT_TITLE: Biomaterials for delivery and maintenance of tip endothelial cells

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Colonization of the small intestine by microbes from the oral cavity has been hypothesized as a key contributor to the pathogenesis of many human diseases, but numerous challenges have prevented this phenomenon from being observed. This exploratory R21 project leverages a unique study design and several innovative technologies, providing a rare opportunity to document colonization of the SI by oral microbes. This study would justify and technologically enable additional studies needed to fill critical knowledge gaps in oral-intestine microbial interactions and how oral microbes affect various interventions (diet, drugs, probiotics, supplements, botanicals, etc.) in the context of human health and disease.

PI_NAMEs: ISMAGILOV, RUSTEM F (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Address;Affect;Biopsy;Biopsy Specimen;Botanicals;Celiac Disease;Childhood;Classification;Cohort Studies;Complementary therapies;Diet;Dietary Intervention;dietary supplements;Disease;DNA;dysbiosis;Endoscopy;Engineered Probiotics;Engineering;fecal microbiome;Future;Genes;Genome;genome sequencing;Gluten;Goals;Growth;gut colonization;gut microbes;gut microbiome;gut microbiota;healing;Health;Human;human disease;Impairment;improved;Inflammatory Bowel Diseases;innovative technologies;Intervention;Intestines;Irritable Bowel Syndrome;Knowledge;Link;Location;longitudinal analysis;Malignant neoplasm of pancreas;Malnutrition;Measurement;Measures;metagenome;metagenomic sequencing;Methodology;Methods;Microbe;microbial;microbial community;microbiome;Micronutrients;microorganism interaction;Mission;mouse model;Mucous Membrane;National Center for Complementary and Integrative Health;novel;Nutrient;nutrition;Oral;Oral cavity;oral microbiome;oral pathogen;pathobiont;pathogen;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;Play;Positioning Attribute;prebiotics;prevent;Probiotics;Process;rational design;Reagent;reconstruction;Research Design;Ribosomal RNA;Role;rRNA Genes;sample collection;Sampling;Shotgun Sequencing;Shotguns;Single Nucleotide Polymorphism;Small intestine mucous membrane;Small Intestines;Source;Stomach;targeted treatment;Taxonomy;Technology;Time;Tissues;tool;United States National Institutes of Health;uptake;whole genome;Work

PROJECT_TITLE: Oral-intestinal microbial translocation and colonization


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE This project will explore the innate immune response against bacterial biofilms through the characterization of the transcriptional and metabolic changes occurring in dendritic cells upon recognition of the most stimulatory component of biofilms, the bacterial amyloids. It will indicate new metabolic pathways as novel therapeutic candidates, starting with the purine pathway, an understudied pathway in DC biology, to strengthen innate responses against biofilm-driven infections.

PI_NAMEs: GALLUCCI, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Abbreviations;Acceleration;adaptive immune response;Amyloid;Antibiotics;Autoimmunity;Bacteria;Bacterial DNA;Biochemical;Biochemistry;Biological Assay;Carbon;cell community;Cells;Cellular biology;chronic infection;Clinical Treatment;community organizations;Complex;cytokine;Dendritic cell activation;Dendritic Cells;Deoxyribonucleases;DNA;Energy Metabolism;Escherichia coli;Exposure to;follow-up;Foundations;Genetic Transcription;Genus Hippocampus;Glycolysis;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Host Defense;Human;Immune response;Immune system;Immunity;immunoregulation;improved;In Vitro;Infection;Inflammatory;Innate Immune Response;innovation;Interferon Type I;Interleukin-6;Kinetics;Knowledge;Ligands;Lipopolysaccharides;Literature;Macrophage;Mass Spectrum Analysis;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Microbial Biofilms;Mitochondria;Modeling;Molecular;monocyte;monomer;Mus;Natural Immunity;novel;novel therapeutics;Oxidative Phosphorylation;pathogen;pathogenic bacteria;Pathway interactions;Pattern;Peptide Hydrolases;Polymers;Production;Pseudomonas aeruginosa;Purines;recurrent infection;Reporting;Resistance;Resolution;response;RNA;Role;Salmonella;Self Tolerance;stable isotope;Stimulus;Testing;Therapeutic;therapeutic candidate;therapeutic target;Tissues;TLR2 gene;TLR4 gene;TLR7 gene;transcriptome;Virulence Factors;Work

PROJECT_TITLE: Reprogramming of the innate immunometabolism by bacterial biofilms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative This proposal focuses on identifying, characterizing, and optimizing small molecules for use as antibiotic adjuvants that inhibit the activity of the chloramphenicol-florfenicol resistance (Cfr) protein. Cfr is a radical S-adenosylmethionine enzyme that methylates adenosine 2503 of 23S rRNA in bacterial ribosomes, conferring resistance to several major classes of currently administered antibiotics across multiple species of pathogenic bacteria, including methicillin resistant Staphylococcus aureus, Enterococcus faecalis, and Clostridiodes difficile. Successful adjuvant-antibiotic combinations will introduce a new treatment strategy that blocks the acquisition of this form of enzyme-mediated resistance by bacteria.

PI_NAMEs: BOOKER, SQUIRE J. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Achievement;Active Sites;Adenosine;Adjuvant;Affect;Affinity;Amino Acids;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacillus;Bacteria;Bacterial Infections;bacterial resistance;Binding;Binding Sites;Biochemical;Biological Assay;Biological Models;Catalysis;Cell Line;Cells;Cessation of life;Chloramphenicol;Clinical;clinically relevant;Clostridium;Clostridium difficile;Combined Antibiotics;Complement;Computer Assisted;Computer software;crosslink;Cryoelectron Microscopy;Crystallization;Data;design;Development;drug discovery;Drug Efflux;efflux pump;Engineering;Enterococcus;Enterococcus faecalis;Enzymes;Escherichia coli;Event;Evolution;experience;experimental study;florfenicol;Genes;Genome;Genus staphylococcus;Health;Homologous Gene;Human;human pathogen;In Vitro;Infection;inhibitor;insight;Laboratories;Left;lincosamide;Listeria;Mammalian Cell;Mass Spectrum Analysis;Measurement;Mediating;methicillin resistant Staphylococcus aureus;methyl group;Methylation;Methyltransferase;Modeling;Modification;Molecular;Molecular Target;Monitor;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Newborn Infant;novel;novel strategies;novel therapeutic intervention;Oxazolidinones;pathogenic bacteria;Persons;Phenotype;Plasmids;pleuromutilin;pressure;prevent;Primer Extension;Property;Protein Biosynthesis;protein structure;Proteins;Protocols documentation;Research Personnel;Resistance;Resistance development;resistance mechanism;Resolution;Ribosomal RNA;Ribosomes;RNA;RNA methylation;RNA, Ribosomal, 23S;RNA-Directed DNA Polymerase;Roentgen Rays;S-Adenosylhomocysteine;S-Adenosylmethionine;Sampling;Site-Directed Mutagenesis;small molecule;Staphylococcus aureus;Streptogramins;Structure;Structure-Activity Relationship;System;Techniques;Temperature;Testing;Therapeutic;Time;Toxic effect;Translational Repression;Variant;virtual;virtual library

PROJECT_TITLE: Development of Antibiotic Adjuvants to Avert Resistance Conferred by Cfr, a Radical S-Adenosylmethionine Methylase

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Pregnancy;Prevention;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Current strategies aiming to reduce the morbidity and mortality associated with malaria-in-pregnancy suffer from critical implementation gaps and are increasingly threatened by the emergence of drug and insecticide resistance. The scientific objective of this Exploratory/Developmental Grant (R21) application is to demonstrate the feasibility, acceptability, and preliminary effectiveness of a focal mass drug administration (fMDA) program for household members of pregnant women to protect against malaria-in-pregnancy. Our hypothesis is that eliminating the parasite reservoir within the household will provide a complementary layer of protection especially when access to care is limited and visits may be delayed or missed.

PI_NAMEs: BOYCE, ROSS MATHEW (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: acceptability and feasibility;Adherence;adverse birth outcomes;Adverse event;Africa South of the Sahara;antenatal;Anti-malarials;Area;Artemisinins;Breeding;Case Management;Child;Clinic;Clinic Visits;Clinical;Combined Modality Therapy;Complement;Country;Data;Data Collection;Diagnostic tests;Disease;Dose;Drug resistance;effective therapy;Effectiveness;Endemic Diseases;Exploratory/Developmental Grant;feasibility trial;Fever;Frequencies;Guidelines;Health Services Accessibility;Home environment;Household;implementation framework;Incidence;Infection;Injectable;innovation;Insecticide Resistance;Insecticides;instrument;Intervention;intervention cost;Lethargies;Live Birth;Low Birth Weight Infant;Malaria;malaria transmission;Measures;member;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;novel;open label;Outcome Study;Parasitemia;Parasites;Pharmaceutical Preparations;Phase;Pilot Projects;placebo controlled trial;placental malaria;Plasmodium falciparum;Pregnancy;pregnancy prevention;Pregnant Women;Prevalence;prevent;Preventive therapy;Preventive treatment;primary health center;Process Assessment;Process Measure;programs;prophylactic;Protocols documentation;Pyrimethamine;Randomized;Randomized, Controlled Trials;Rapid diagnostics;Recommendation;recruit;Regimen;Reporting;Research;Research Design;Residual state;retention rate;Risk;Risk Reduction;Rural;Safety;Site;spatiotemporal;stillbirth;Sulfadoxine;Sulfadoxine-pyrimethamine resistance;Symptoms;Technical Expertise;Testing;theories;Time;tool;treatment as usual;Treatment Efficacy;Uganda;unborn child;uptake;Vaccines;vector control;Visit;Vulnerable Populations;willingness;Woman

PROJECT_TITLE: Reducing malaria in pregnancy through focal drug administration in household members: A pilot feasibility trial

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Understanding the quantitative relationships between sequential mosquito stages is critical to a better understanding of transmission of the malaria parasite to the human host. This proposal aims to develop automated image processing techniques based on deep learning and super- resolution imaging to accurately determine the number of sporozoites in single oocysts. This methodology will provide new approaches to understanding the most under-studied stage of the malaria parasite.

PI_NAMEs: KANATANI, SACHIE  (contact);SINNIS, PHOTINI

PROJECT_TERMS: 3-Dimensional;Africa South of the Sahara;African;Asian;Classification;Consumption;Culicidae;Data;deep learning;deep learning model;Development;Gene Expression;Geography;Growth;Human;Image;image processing;improved;In Situ;In Vitro;India;Individual;Infection;Laboratories;Life Cycle Stages;Link;Malaria;malaria transmission;Manuals;Methodology;Methods;Microscope;Midgut;Nature;novel strategies;Oocysts;Parasites;Phase;Plasmodium;Plasmodium falciparum;promoter;Protein Overexpression;Proteins;Public Health;reconstruction;Rupture;Sporozoites;Stains;Structure;superresolution imaging;superresolution microscopy;Techniques;Thick;Time;Training;transmission process;Tubulin;Validation;vector;vector mosquito

PROJECT_TITLE: Image-based quantification of Plasmodium sporozoites in a single oocyst using deep learning-based segmentation and 3D reconstruction

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The proposed work is relevant to NIH's mission statement because it seeks to dissect the precise RNA editing landscape mediated by the oncogenic RNA deaminase ADAR1 in T-cell leukemia initiating cell propagation. Thus, it will accelerate future epi-transcriptomic research in pediatric cancer and will open new avenues to prevent disease relapse in T-ALL.

PI_NAMEs: JIANG, QINGFEI  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Acceleration;Acute T Cell Leukemia;Adenosine;adenosine deaminase;Adult;Biology;cancer type;Cell Maintenance;Cells;Child;Childhood Precursor T Lymphoblastic Leukemia;Classification;Clinical;clinically relevant;cohort;Collection;Communities;conventional therapy;Data Set;Development;Disease Outcome;DNA Sequence Alteration;Double-Stranded RNA;dsRNA adenosine deaminase;epitranscriptomics;Evaluation;Event;Exhibits;Future;Gene Expression;Genes;Genetic;Goals;Hematopoietic stem cells;Human;Impairment;Individual;Innate Immune Response;Inosine;insight;interest;Knowledge;Lesion;leukemia;leukemia initiating cell;leukemia relapse;leukemic stem cell;Life Expectancy;Link;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medical;Mission;Modification;molecular subtypes;mouse model;Mutation;novel;novel therapeutics;Oncogenes;Oncogenic;Outcome;Pathogenesis;Patients;Pediatric Research;Play;prevent;Prevention strategy;Prognostic Marker;programs;Recurrence;Recurrent disease;Refractory;Regulation;Relapse;Reporting;Research;RNA;RNA Editing;Role;Sample Size;self-renewal;Site;success;Survival Rate;T-Cell Leukemia;therapeutic target;therapy resistant;transcriptome;transcriptomics;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Profiling Epitranscriptomic RNA editing in Pediatric Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric

ORG_DEPT: BIOLOGY

ORG_NAME: STATE COLLEGE OF OPTOMETRY

PHR: PROJECT NARRATIVE Amblyopia is the second biggest cause of vision problems in children, and negatively impacts their life including reading performance. Adult amblyopes draw distorted percepts of gratings and letters that indicate abnormal development pf orientation processing in cortex, and such distortions would hamper children’s reading and learning, but it is not known when these distortions first occur, how they develop, and if they respond to treatment. Children’s drawings are unlikely to be accurate representations of percepts, so to answer these questions, we will use Generative Adversarial Networks to make perceptograms of the distortions amblyopic children perceive in gratings, letters, and numbers. In parallel we will build neural models of orientation encoding and decoding that provide insights into the development of perceived shape distortions. These tools will transform studies of childhood amblyopia and possibly other childhood visual disorders.

PI_NAMEs: ZAIDI, QASIM  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Shape Distortions seen by Amblyopic Children: Pereceptograms and Neural Models

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Narratives Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by the formation of scar tissue (fibrosis) in the lungs, which reduces their ability to function properly. The proposed research aims to develop an animal model to investigate the mechanical mechanisms underlying the progression of IPF and to use this model as a preclinical platform for developing mechanobiological therapies.

PI_NAMEs: HUANG, YONG  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acute;Adult;Affect;Age;aged;Aging;aging related disease;Animal Model;Architecture;Biochemical;Bioinformatics;Biological Assay;Bleomycin;Breathing;Candidate Disease Gene;cell behavior;Cell Physiology;cell type;Cells;Cicatrix;Clinical;Collagen;Communities;Complex;Contralateral;Coupled;Deposition;Development;Dimensions;Disparity;Epithelial Cells;Etiology;expiration;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;Gene Expression;Genes;Goals;Harvest;Histologic;Histology;human old age (65+);idiopathic pulmonary fibrosis;in vivo;indium-bleomycin;Inflammation;Injury;innovation;Insula of Reil;Integrins;Investigation;Ipsilateral;Left;Lobe;Lobule;Lung;lung histology;lung injury;lung repair;Malignant Neoplasms;mechanical load;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Microscopic;Modeling;Molecular;Molecular Profiling;Molecular Target;Movement;Mus;Muscle;Myofibroblast;novel;old mice;Pathologic;Pathway Analysis;Pathway interactions;Patients;Pattern;Periodicity;Peripheral;Phase;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Process;Progressive Disease;Proteins;Publishing;Pulmonary Fibrosis;Quality of life;Radiology Specialty;Reporting;Research;Respiration;Respiratory Diaphragm;Respiratory Paralysis;response;Role;sham surgery;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stretching;Structure of parenchyma of lung;Structure of phrenic nerve;Time;Tissues;transcriptome sequencing;transcriptomic profiling;United States;Usual Interstitial Pneumonia;X-Ray Computed Tomography

PROJECT_TITLE: Impact of mechanical stretch on the progression of pulmonary fibrosis in mouse bleomycin model

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Vascular cells inside the tumor, or tumor endothelial cells, play a significant role in determining tumor aggressiveness and we had previously shown that lower levels of a small tumor suppressor gene, called microRNA-1 in these cells enhances their proliferation and tumor growth. We have recently found that an enzyme called terminal endonucleotidyl transferase, or TENT2, is responsible for microRNA-1 downregulation in tumor endothelial cells. In this study we will determine the molecular effects of TENT2 on microRNA-1 and its pathogenic role in promoting lung tumor growth.

PI_NAMEs: TAKYAR, SEYEDTAGHI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adenine;adenylate;angiogenesis;Blood Vessels;cancer cell;Cancer Etiology;Cancer Patient;Cell Proliferation;Cell Separation;Cells;Chronic;Clinical;cytokine;Down-Regulation;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;Experimental Models;experimental study;Gene Expression;Genetic;Genetic Models;Genetic Transcription;Immune checkpoint inhibitor;Immunity;Investigation;Kinetics;knock-down;Knock-out;Knockout Mice;KRAS2 gene;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Measures;Messenger RNA;MicroRNAs;Modality;Modification;Molecular;Molecular Abnormality;mortality;Mus;mutant;Non-Small-Cell Lung Carcinoma;novel therapeutics;Nucleotides;nucleotidyltransferase;overexpression;Pathogenicity;Patients;Play;Process;Prognosis;Proliferating;Protein Isoforms;recruit;Regulation;RNA;RNA-Induced Silencing Complex;Role;Small RNA;Structure of parenchyma of lung;success;Testing;TP53 gene;transcriptome sequencing;Transferase;tumor;Tumor Angiogenesis;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;United States;Untranslated RNA;Variant;Vascular Endothelial Growth Factors

PROJECT_TITLE: 3' RNA modification enzymes regulate tumor angiogenesis in non-small lung cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative A growing body of literature shows a positive association between racial discrimination and substance use among Black college students, mostly measured using retrospective self-report and cross-sectional surveys with an emphasis on alcohol as a substance use outcome. While valuable, prospective studies are needed to identify racial discrimination as a real-time antecedent to various types of substance use (alcohol, nicotine, marijuana, and other drugs) and substance use patterns (e.g., types of use, quantity of use, co-use) among Black college students, particularly those who attend Predominately White institutions. Addressing a health equity issue, the proposed project aims to use ecological momentary assessment to detect fluctuations in Black college students’ substance use behaviors given real-time experiences of racial discrimination while exploring affective, social, and cognitive mechanisms by which racial discrimination confers risk for substance use.

PI_NAMEs: PEOPLES, JANIENE  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Affective;African American student;Alcohols;Area;Attention;Behavior;Behavioral Research;Black American;Black race;black subgroup;Cognitive;cognitive process;Collection;college;Communities;Cross-Sectional Studies;Data;Data Set;Development;Disparity;Distal;Drug usage;Ecological momentary assessment;Ensure;Environment;experience;Exposure to;Future;Goals;Health;health disparity;health equity;Heterogeneity;high risk;Home;Hypertension;in vivo;Individual;innovation;Institution;Intervention;Investigation;Knowledge;Link;Literature;marginalized population;Marijuana;Measures;Mediating;Mediation;Mental Depression;multilevel analysis;National Institute of Drug Abuse;negative affect;Nicotine;Outcome;Participant;Patient Self-Report;Pattern;perceived discrimination;Persons;Pharmaceutical Preparations;polysubstance use;pressure;prevent;Process;prospective;Prospective Studies;psychologic;psychosocial;Public Health;Race;racial discrimination;Racial Equity;racism;recruit;Reporting;Research;Research Design;response;Retrospective Studies;Risk;Risk Factors;Role;rumination;Skin;social;Social Processes;social stigma;Social support;Statistical Data Interpretation;Statistical Models;Strategic Planning;Stress;stressor;substance misuse;substance use;theories;Time;United States;Universities;university student;Washington;young adult

PROJECT_TITLE: Ecological Momentary Assessment of Mechanisms Linking Racial Discrimination and Substance Use in Black College Students

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The objective of this project is to understand the principles of molecular structure and supramolecular organization underlying how crystallin proteins control the refractive index of the eye lens. Optical and biophysical measurements will be used to characterize the features of the crystallin fold and interactions among side-chains that contribute to these proteins’ elevated refractivity. The insights gained from this project will enhance our understanding of the biophysics underlying lens function and guide the future design of improved artificial lens materials.

PI_NAMEs: MARTIN, RACHEL WAGNER (contact)

PROJECT_TERMS: 3-Dimensional;Amino Acids;aquatic organism;Biology;biophysical analysis;biophysical properties;Biophysics;Cataract;Cations;constriction;Crowding;Crystalline Lens;Crystallins;design;Development;device Artificial lens;Egg White;Engineering;Environment;Escherichia coli;experimental study;Eye;fiber cell;Fishes;Future;Goals;Human;Hydration status;Hydrogels;hydroxyl group;Image;improved;Individual;insight;instrumentation;intermolecular interaction;Investments;Knowledge;lens;Lens Fiber;Light;Mass Spectrum Analysis;Measurement;Measures;Membrane Proteins;Metabolism;Methodology;Methods;model organism;Modeling;Molecular;Molecular Probes;Molecular Structure;Muramidase;Mutagenesis;Mutation;novel;Optics;Organelles;Pathology;Physiological;Post-Translational Protein Processing;Property;protein degradation;protein distribution;protein structure;Proteins;quantum;Refractive Indices;Research;Retina;Sampling;Solubility;Structure;Surface;surgery material;System;Tertiary Protein Structure;Testing;three dimensional structure;Tissues;Variant;Visualization;Water;Work;Zebrafish

PROJECT_TITLE: Probing the molecular basis of refractive index in lens proteins

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Many human diseases are systemic in nature, yet few tools are available to quantify chemical and energetic flows at a systems level. The goal of this project is to quantify metabolic fluxes on a whole-body level using in vivo isotope tracing and in silico machine learning. Upon successful completion of this project, we will gain quantitative insights into how metabolism rewires systemically depending on nutrient availability.

PI_NAMEs: LAI, PIN-KUANG ;PARK, JUNYOUNG O. (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Adoption;Affect;Anabolism;Animals;Biochemical Pathway;Biochemical Reaction;Carbon;Cardiovascular system;Cell Culture System;Cell Line;Cell Proliferation;cell type;Cells;Chemicals;Coculture Techniques;Communities;Complex;cost;Data;deep learning;deep learning model;design,build,test;Diabetes Mellitus;Diet;Disparate;Enzymes;experimental study;Face;Fasting;Foundations;Goals;healing;Homeostasis;Human body;human disease;in silico;in vivo;Individual;Infusion procedures;insight;Isotope Labeling;Isotopes;Kinetics;Knowledge;Label;Laboratories;Laws;Learning;Machine Learning;machine learning model;Mammals;Maps;Mathematics;Measurement;Measures;Metabolic;Metabolic Pathway;Metabolic syndrome;Metabolism;Methods;model organism;Modeling;Molecular;multiple data types;Mus;Nature;neural network;Nutrient;Nutrient availability;Organ;Output;Pathway interactions;Pattern;Population;Positioning Attribute;predictive modeling;Process;Proliferating;quantum;Research;Research Personnel;simulation;Software Tools;Solid;Source;stable isotope;Supporting Cell;Suspensions;System;Systemic disease;Techniques;therapy development;Thermodynamics;tissue culture;Tissues;tool;Tracer;Training;Transport Reaction;uptake;Vertebral column;wasting

PROJECT_TITLE: Whole-body-level metabolic flux quantitation by machine learning

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Primary Health Care;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Post acute-COVID syndrome (PACS, or Long COVID) includes symptoms of severe fatigue, brain fog, anxiety, depression and pain, affects millions of Americans, and can cause significant disability, including loss of employment and inability to conduct activities of everyday life. Patients with PACS living in rural communities, like those in northern New England, face increased challenges due to heath disparities related to physical and social isolation and a shortage of providers with expertise in managing this condition. We aim to develop useful, understandable and relatable information for patients and providers living and working in this environment, in partnership with biomedical and rural libraries, which are often primary hubs of information in this region.

PI_NAMEs: PARSONNET, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Access to Information;Activities of Daily Living;Acute;Address;Advocate;Affect;American;Anxiety;Area;Awareness;brain fog;Caring;Chronic Disease;Clinic;Clinical;Clinical Services;Collaborations;Communities;community based participatory research;community engagement;Community Healthcare;community organizations;Complex;Comprehensive Health Care;Computers;COVID-19;COVID-19 patient;Creativeness;deprivation;digital;disability;Disadvantaged;Educational Materials;Educational process of instructing;Elements;Emotional;Employment;empowerment;Environment;evidence base;experience;Face;Fatigue;Foundations;Goals;Health;health care disparity;Health care facility;health disparity;health disparity populations;Health education;health literacy;Health Personnel;Health Status;improved;indexing;Information Technology;innovation;Institution;Internet;Knowledge;Learning;Librarians;Libraries;Link;Literacy Programs;Lived experience;Long COVID;Measures;Medical;Mental Depression;Mental Health;Mental Health Services;multidisciplinary;Nature;Neighborhood Health Center;New England;New Hampshire;Newsletter;Occupational Therapist;Occupational Therapy;Occupations;online repository;online resource;outreach;Pain;Pathway interactions;Patient Care;patient oriented;patient population;Patients;persistent symptom;Persons;physical therapist;Physical therapy;Population;post-COVID-19;Primary Care;primary care provider;programs;Provider;psychosocial;Punishment;Quality of life;rehabilitation service;Rehabilitation therapy;Reporting;Research;Resolution;Resources;Rural;rural area;Rural Community;rural environment;Rural Health;rural patients;Rural Population;rural setting;Science;Security;Services;Social isolation;Source;Specialist;Speed;success;Symptoms;Syndrome;System;tool;Treatment Protocols;Trust;United States Health Resources and Services Administration;usability;Vermont;Vulnerable Populations;web site

PROJECT_TITLE: Long COVID Health Literacy Project: Bringing Health Information to Patients and Providers with Health Disparities in Rural Northern New England

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-G (01)]


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: (Note: this section remains unchanged) This research will determine how serum amyloid A (SAA), a protein that cleans up lipids from injured sites, aggregates in vital organs leading to organ damage in inflammation. This research will also determine how SAA and other aggregating proteins interact with amyloid modulators. These interactions play critical roles in ~40 life-threatening human disorders including Alzheimer’s, Parkinson’s and other amyloid diseases; research such as ours will help design much-needed treatments for these incurable diseases.

PI_NAMEs: GURSKY, OLGA  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acute;Acute-Phase Proteins;Address;Affect;Affinity Chromatography;All-Trans-Retinol;Alzheimer's Disease;Amyloid;Amyloid beta-Protein Precursor;Amyloid deposition;amyloid formation;Amyloid Proteins;Amyloidosis;Anisotropy;Antibodies;Apolipoprotein E;Autoimmune Diseases;Binding;Biochemical;Biological Assay;biophysical techniques;Cell membrane;Cessation of life;Chronic;chronic infection;Circular Dichroism;Clear Cell;Clinical Trials;cofactor;Complex;Complication;Computing Methodologies;Crohn's disease;Data;Deposition;design;Development;Disease;Dot Immunoblotting;Drops;Electron Microscopy;Electrons;Ensure;Enzyme-Linked Immunosorbent Assay;Excision;Face;Failure;fascinate;Fatty Acids;feasibility research;fibrillogenesis;Fluorescence Spectroscopy;Glycosaminoglycans;Goals;healing;Health;Heparin;Heparitin Sulfate;High Density Lipoproteins;Homeostasis;Human;Hydrolysis;Hydrophobicity;Incubated;Infection;Inflammation;injured;Injury;Life;Ligands;Link;Lipid Binding;lipid nanoparticle;Lipids;Lipolysis;Lipoproteins;liver injury;Malignant Neoplasms;Metabolic;Methods;Microscopic;mimetics;Modeling;Molecular;Molecular Sieve Chromatography;molecular targeted therapies;Mus;nanolipoprotein particles;nanoparticle;Nerve Degeneration;new therapeutic target;Organ;Parkinson Disease;particle;Pathologic;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;Phospholipase A2;Pilot Projects;Plasma;Play;Process;Progress Reports;protein aggregation;Proteins;Proteolysis;Publications;Publishing;Recombinants;reconstitution;renal damage;Research;Rheumatoid Arthritis;Role;Serum amyloid A protein;Site;small molecule;Spectroscopy, Fourier Transform Infrared;stem;Structure;synergism;synuclein;tau Proteins;Testing;therapeutic target;Tissues;tool;Tuberculosis

PROJECT_TITLE: Structure and Function of Serum Amyloid A in Health and Disease

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurodegenerative;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: A wide variety of environmental agents, from anticancer chemotherapies to commonly used pesticides, induce proteotoxic stress, causing toxic side effects limiting usage of prescription drugs, and predisposing individuals to diseases such as cancer and neurodegenerative disorders. Here, we will create a comprehensive map of the cytoprotective networks that promote cell resilience in the face of common environmental insults. This map will serve as a major resource for the research community, provide a more complete understanding of cellular environmental stress response programs, and lead to insights into the large variability in the risk of adverse events that arise from exposure to these insults.

PI_NAMEs: MENDILLO, MARC  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acute;adverse event risk;Affect;anti-cancer;Biological;biological adaptation to stress;Cell Line;Cells;cellular resilience;Cellular Stress;chemical genetics;Chemotherapy-Oncologic Procedure;Chromosome Mapping;Classification;Clinical;Communities;computational pipelines;computer framework;coping;Coupled;Cytoprotection;Data;data access;Development;Diagnostic;Disease;Disease susceptibility;DNA;Drug Prescriptions;environmental agent;environmental stressor;Exposure to;FDA approved;fitness;functional genomics;Future;gene network;Generations;Genes;Genetic;genetic profiling;Genetic Screening;genetic signature;Genetic Transcription;genomic platform;Growth;Health;Hepatocyte;high reward;high risk;Human;Individual;insight;Kidney;kidney cell;Libraries;Literature;Liver;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Molecular;Molecular Chaperones;Nerve Degeneration;Neurodegenerative Disorders;novel;online resource;Pathway interactions;Pesticides;Phenotype;Play;programs;Proteins;Proteome;proteostasis;proteotoxicity;Publishing;Regulation;Research;research clinical testing;resilience;Resolution;Resources;response;Retina;Role;sensor;side effect;Signal Transduction;Stress;Stress Response Signaling;stressor;Titrations;tool;Toxic effect;Toxic Environmental Substances;Toxin;transcriptome;transcriptome sequencing;user-friendly;Validation;Variant;Visualization;web app;Work

PROJECT_TITLE: Genetic Map of the Mammalian Cell Response to Environmental Stress

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Although the revolution in DNA sequencing in the last 20 years has transformed our understanding of how life operates, we are still discovering the many ways that healthy and diseased states arise from how cells “decide” to make proteins from DNA sequences. The work proposed here combines experiment, theory, and computation to reveal—across scales—how these “decisions” are made through bursts of transcription in the embryo of the fruit fly, a powerful model system for developmental biology. The proposed investigations will set the stage for the predictive bioengineering of multicellular organisms and future precision therapeutic tools for repairing developmental defects and halting states of unchecked cellular proliferation in cancer.

PI_NAMEs: GARCIA, HERNAN GUSTAVO (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: adaptive optics;Architecture;Automobile Driving;Behavior;Binding;Biochemical;Biological Models;Biomedical Engineering;Cell Nucleus;Cell Proliferation;Cells;Data;Decision Making;Defect;design;Development;Developmental Biology;Developmental Gene;Disease;disease-causing mutation;Dissection;DNA;DNA Binding;DNA Sequence;DNA sequencing;Dorsal;Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;empowerment;Engineering;Enhancers;Eukaryota;Event;Exhibits;experimental study;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Image;in vivo;Individual;insight;Investigation;Knowledge;Life;Light;Link;Maintenance;Malignant Neoplasms;markov model;Measurement;Measures;Mediating;Messenger RNA;Microscopy;Modality;Molecular;Molecular Probes;molecular scale;new technology;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Organism;Output;Pattern Formation;Play;Precision therapeutics;Prevalence;Process;programs;promoter;Proteins;rational design;repaired;Role;Scientist;Shapes;single molecule;Site;Snails;synergism;Techniques;Technology;temporal measurement;Testing;Theoretical model;theories;Time;tissue fixing;tool;transcription factor;Transcriptional Regulation;ultra high resolution;Visualization;Work

PROJECT_TITLE: In vivo mechanisms of Dorsal-mediated transcriptional control in development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Valley Fever

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: Project Narrative This project will identify immunogenic antibodies in response to coccidioidomycosis, an endemic fungal infection in the southwestern United States. Using two innovative technologies, we aim to measure antigen-antibody binding events across the Coccidioides proteome at epitope level resolution, significantly increasing the number of diagnostics targets. Our project will generate and validate a diverse panel of novel monoclonal antibodies which can be developed as therapeutic or vaccine targets in addition to improving current diagnostic tools.

PI_NAMEs: MEAD, HEATHER LYNN (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acute;Address;Algorithms;Antibodies;antibody and antigen binding;antibody test;Antibody-mediated protection;Antigen Targeting;Antigens;Area;B-Lymphocytes;Bar Codes;Binding;Biological Assay;Cell Separation;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;cohort;cost effective measures;Coupled;Data;design;Development;Diagnostic;diagnostic assay;diagnostic development;diagnostic panel;Diagnostic tests;diagnostic tool;diagnostic value;Disease;DNA;Enzyme-Linked Immunosorbent Assay;Epitopes;Event;Frequencies;Future;Genomics;Human;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;improved;Infection;innovative technologies;internal control;Investigation;Length;Libraries;Measures;Memory B-Lymphocyte;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mycoses;neutralizing antibody;novel;Outcome;Patients;Pattern Recognition;Peptide Library;Peptides;Performance;Plasma;Portraits;Proteins;Proteome;Rapid diagnostics;Reporting;Resolution;response;Role;Sampling;Serodiagnoses;Serology;Serology test;single cell sequencing;Slide;Southwestern United States;Specificity;Testing;Therapeutic;Time;Vaccines;Viral;Virus

PROJECT_TITLE: Proteome-wide Discovery of Diagnostic Targets for Coccidioidomycosis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative The central goal of this proposed work is to understand the integrated role of inflammation and the sympathetic nervous system in mediating increased sodium (Na) reabsorption during hypertension (HTN). Specifically, this work will explore adrenergic receptor activation on renal dendritic cells, and their contribution to cytokine- mediated increases in blood pressure. This study will allow new avenues for exploitation of possible therapeutic options. Reducing Na reabsorption will decrease blood pressure and end organ damage.

PI_NAMEs: WYNNE, BRANDI MICHELE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;absorption;Adrenergic Receptor;Affinity;Aldosterone;Animal Model;Anti-Hypertensive Agents;antibody test;Antibody-drug conjugates;base;Blood Pressure;blood pressure elevation;blood pressure reduction;Cardiorenal syndrome;cell immortalization;Cell Line;Cell secretion;Cell Survival;Cells;Clinical;Coculture Techniques;Collaborations;cytokine;Data;Dendritic cell activation;Dendritic Cells;Denervation;Dependence;Development;Distal;Electrolytes;Epithelial Cells;epithelial Na+ channel;Excretory function;Funding;Future;Goals;high salt diet;Hypertension;hypertensive;Immune;immune activation;Immune Targeting;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;inflammatory milieu;Infusion procedures;innovation;Interleukin-6;Kidney;Link;Mediating;Messenger RNA;Methods;Mineralocorticoid Receptor;Modeling;Molecular;Mus;Natriuresis;Nephrons;Nerve;nerve supply;Norepinephrine;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathway interactions;Persons;pharmacologic;Phosphorylation;Physiological;Plasma;Play;Population;Production;Receptor Activation;receptor expression;Receptor Inhibition;Receptor Signaling;Risk Factors;Role;salt sensitive hypertension;Sodium;Sodium Chloride;Stimulus;Sympathetic Nervous System;symporter;Telemetry;Testing;Therapeutic;tool;transcriptome sequencing;Tubular formation;urinary;western diet;Work

PROJECT_TITLE: Sympathetic Activation of Renal Dendritic Cells in Hypertension

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Very Brief Exposure (VBE) -- the presentation of a series of masked pictures representing a person’s fears (e.g., judgmental faces) -- reduces fear and avoidance during in vivo exposure to the real-life situation, and does not induce distress. We will develop VBE from Specific Phobia to target Social Anxiety Disorder (SAD), and acquire preliminary fMRI data to determine if VBE activates the same neural circuits as in Specific Phobia, and that it does so specifically in transition age youth with SAD, 16-22 years old.

PI_NAMEs: PETERSON, BRADLEY S (contact);SIEGEL, PAUL

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: active control;Adolescent;Age;American;Anger;Anxiety Disorders;Arousal;avoidance behavior;Awareness;Bypass;Clinic;Cognitive Therapy;Complex;Conscious;cost;Data;Development;Disease;Distress;Dropout;Effectiveness;effectiveness study;efficacious treatment;Evaluation;experience;exposure reduction interventions;Exposure to;Extinction;Face;Fright;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Galvanic Skin Response;Goals;Human;Image;Impairment;improved;in vivo;Intervention;Judgment;Learning;learning extinction;Life;Masks;Medial;Mediating;Mental Depression;Mental Health;Modality;Modeling;neural circuit;novel;pandemic disease;Patients;Periodicals;Persons;Phobias;prevent;Process;Psychophysiology;Randomized, Controlled Trials;Research;response;Schools;Series;Social Anxiety Disorder;social interventions;Specific Phobia;Spiders;Stimulus;Testing;Therapeutic Effect;therapeutic target;therapy development;Training;Translating;treatment of anxiety disorders;Unconscious State;willingness;Work;Youth

PROJECT_TITLE: Very Brief Exposure: Exploratory Development of a Novel Exposure Modality for Social Anxiety Disorder in Transition-Age Youth

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE This study will use state of the art tools to directly visualize and functionally analyze the human polyclonal and monoclonal antibody responses to measles virus vaccination for the first time. The information learned will explain how this successful vaccine works and will provide direction for development of next-generation vaccines and novel therapeutics targeting measles and other viruses in its broad paramyxovirus family.

PI_NAMEs: SAPHIRE, ERICA OLLMANN (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Acceleration;Anti-viral Agents;Antibodies;Antibody Response;Antibody Therapy;Antibody titer measurement;Antigens;Attenuated Live Virus Vaccine;Attenuated Vaccines;B-Lymphocytes;Binding;Binding Sites;climate change;comparative;Complex;COVID-19;COVID-19 pandemic;Dedications;Developed Countries;Development;Disease;Disease Outbreaks;Ebola virus;Electron Microscope;Electron Microscopy;Epitope Mapping;Epitopes;Event;experience;extreme weather;Family;Funding;global health;Glycoproteins;group competition;health inequalities;Hemagglutinin;Human;human monoclonal antibodies;Immune response;Immune system;Immunization;Immunization Programs;Immunocompromised Host;Immunodominant Epitopes;Individual;Infection;innovation;instrumentation;Interruption;Kinetics;Knowledge;Lassa virus;Lead;Learning;Maps;Measles;Measles virus;Mediating;Membrane Glycoproteins;Microfluidics;Modernization;Monoclonal Antibodies;murine antibody;murine monoclonal antibody;Mus;Mutagenesis;Mutation;nanoparticle;National Institute of Allergy and Infectious Disease;Nature;Negative Staining;neutralizing antibody;new therapeutic target;novel;novel vaccines;Paramyxovirus;pathogen;Peptides;polyclonal antibody;polyclonal human antibody;Population;programs;prototype;Public Health;Rapid screening;receptor binding;response;RNA vaccine;RNA Viruses;Serology;Severe Acute Respiratory Syndrome;Site;Structure;success;Surface Antigens;Therapeutic;Time;tool;Vaccination;vaccine development;vaccine hesitancy;Vaccinee;Vaccines;Viral Antigens;Virus;Visualization;Work

PROJECT_TITLE: What is the human antibody response to measles virus vaccination?

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

ORG_STATE: OR

PHR: PROJECT NARRATIVE Adolescence is characterized both by an increased prevalence in depressive symptoms as well as greater salience of friends, with increased intimacy and self-disclosure in friend conversations. The current project aims to explore granular processes that may contribute to depression contagion, by studying how adolescent best friend interactions can influence each other’s depressed and positive affect in daily life using an experience sampling method design. Online and offline communication will be studied as interpersonal mechanisms expected to drive depression contagion to increase insight into targets for preventative intervention, and individual difference characteristics will be included as factors that may moderate risk for contagion.

PI_NAMEs: BASTIN, MARGOT  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adverse effects;Affect;Affective;Automobile Driving;Behavior;Cellular Phone;Characteristics;Childhood;Communication;communication behavior;Communities;contagion;critical period;Data;Depressed mood;Depression screen;Depressive disorder;depressive symptoms;design;Development;digital communication;Distress;Empathy;Environment;Event;experience;Exploratory/Developmental Grant;follow-up;Friends;Friendships;Genetic Complementation Test;Happiness;Health;Individual;Individual Differences;insight;Intervention;intimate behavior;Investigation;Knowledge;Life;longitudinal design;Measurement;Mediating;Mediator;Mental Depression;Mental Health;Meta-Analysis;Methods;Modeling;negative affect;Outcome;Parents;peer;peer influence;Persons;Prevalence;Prevention;Preventive;preventive intervention;Process;recruit;Reporting;Research;response;Risk;Risk Behaviors;rumination;Sampling;screening;Self Disclosure;sensor technology;sex;Shapes;Signal Transduction;Social Environment;Social Processes;Social support;Source;Symptoms;Techniques;Time;Well in self;Work;Youth

PROJECT_TITLE: Communication and Emotional Well-Being in Adolescent Best Friend Dyads: An Experience Sampling Method Study

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative An effective vaccine is needed to control HIV infections that are still afflicting millions of individuals worldwide. Our proposed study will evaluate the use of monoclonal antibodies to construct immune complex vaccines that will optimize the induction of antibodies against the HIV envelope. Findings from this study will provide information that could lead to the development of new strategies for designing the urgently needed HIV vaccines.

PI_NAMEs: HESSELL, ANN JONES;HIOE, CATARINA E (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Affinity;Antibody Response;Antibody Specificity;Antibody titer measurement;Antigen-Antibody Complex;Antigens;Apical;Avidity;Binding;Binding Sites;Blocking Antibodies;clinical application;Complex;Crowns;Data;design;Development;Distal;DNA;DNA Vaccines;env Gene Products;Epitopes;Evaluation;experimental study;Fab Immunoglobulins;Generations;Glycoproteins;Goals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;HIV-1;Immune;Immunization;Immunize;immunogenic;immunogenicity;Immunoglobulin Fragments;Immunoglobulin G;Immunologic Tests;immunoregulation;Impairment;in vitro testing;Individual;Infection;Infection Control;Macaca;Macaca mulatta;Mediating;Monoclonal Antibodies;Mus;novel;Oryctolagus cuniculus;pandemic disease;polyclonal antibody;prevent;Property;protective efficacy;Proteins;Publishing;Regimen;Reporting;response;Rhesus;Shapes;simian human immunodeficiency virus;Site;Specificity;T cell response;Testing;Vaccination;vaccine development;Vaccines;Viral;Viral Physiology;virus envelope

PROJECT_TITLE: Using immune complex vaccines to optimize antibody responses to HIV Env


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Tumor heterogeneity, the evolution of tumor subclones driven by distinct oncogenes, is a universal phenomenon across solid tumors that is correlated with poor prognosis in patients. In this proposed work, I model tumor heterogeneity by co-culturing cells either overexpressing MYC or expressing oncogenic RAS, to characterize how the unique behaviors of tumor subclones expressing different oncogenes elicit emergent tumor properties and promote tumor progression. Understanding this cooperation will provide key insights into the functional significance of tumor heterogeneity and will be critical towards uncovering future therapeutic interventions to treat heterogenous tumors.

PI_NAMEs: NAKAGAWA, RACHEL MARIE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acceleration;Adopted;Area;Automobile Driving;Biochemical;Breast Cancer Model;breast cancer progression;Breast Epithelial Cells;Cell Culture Techniques;Cell Line;Cell Proliferation;Cell Reprogramming;Cell secretion;Cells;Cessation of life;Coculture Techniques;Collection;Communication;Complex;Cultured Cells;Data;Dependence;Development;Disease;Drug resistance;Engineering;Evolution;exosome;experimental study;Functional dependence;Future;Genetic Heterogeneity;Genetic Transcription;Goals;Heterogeneity;Human;human disease;improved;In Vitro;in vivo;Individual;insight;intercellular communication;Investigation;Knowledge;Label;Libraries;Maintenance;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;MCF10A cells;Mediating;Modeling;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Oncogenes;Oncogenic;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Population;Prognosis;Proliferating;Property;Proteins;Research;response;Signal Transduction;Solid;Solid Neoplasm;Sorting;Stains;Study models;subclonal heterogeneity;suicide gene;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Tissues;transcriptome;transcriptome sequencing;treatment response;tumor;tumor behavior;tumor growth;tumor heterogeneity;tumor initiation;tumor progression;Tumor Promotion;tumor xenograft;Tumor-Derived;tumorigenic;Work

PROJECT_TITLE: Investigating the function of subclonal cooperation in breast cancer progression