NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: 8. Project Narrative The proposed research is relevant to public health because it will advance the capabilities of clinical MR scanners to image specific molecular signatures of primary brain tumors. The new features will provide rapid scanning, improved data quality, and automated data analytics for clinical use. This would enable precision oncology in patients with mutant IDH glioma tumors for early diagnosis, treatment planning, and clinical translation of targeted therapies. Hence, this research is relevant to NCI’s mission to advance diagnosis and treatment of cancer.

PI_NAMEs: ANDRONESI, OVIDIU C (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Age;Agreement;analysis pipeline;artificial neural network;Big Data;Biological Markers;Biopsy;Brain;Brain imaging;Brain Neoplasms;Cancer Etiology;cancer imaging;Cancer Patient;cancer therapy;Cessation of life;chemoradiation;chemotherapy;Classification;Clinical;clinical phenotype;clinical translation;Clinical Trials;Computer software;cost effective;Data Analytics;data quality;deep learning;denoising;Detection;Development;Diagnosis;diagnostic tool;Diffuse;Early Diagnosis;Enzymes;Epigenetic Process;Evaluation;Event;first-in-human;Gene Expression;Generations;Glioma;Goals;Growth;Image;imaging agent;imaging biomarker;Imaging Device;imaging modality;Immune response;improved;improved outcome;in vivo;in vivo imaging;Individual;inhibitor;innovation;Isocitrate Dehydrogenase;Joints;Knowledge;Life;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Metabolic;metabolic imaging;Methods;Mission;Modification;Molecular;molecular imaging;molecular marker;Molecular Profiling;Monitor;Motion;mutant;Mutation;Nervous System Disorder;neuro-oncology;new therapeutic target;next generation;Noise;novel;Oncogenic;Operative Surgical Procedures;Outcome;Pathology;patient population;Patient-Focused Outcomes;Patients;Performance;Persons;precision oncology;Primary Brain Neoplasms;Prognosis;Public Health;Quantitative Evaluations;Radiation;reconstruction;Research;Resolution;response;Sampling Biases;Scanning;Signal Transduction;success;Survival Rate;targeted therapy trials;targeted treatment;Testing;Therapeutic;Time;tool;Translating;treatment planning;treatment response;tumor;Tumor Burden;Tumor Promotion;Update;usability;user-friendly;Vaccines;Work

PROJECT_TITLE: Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Emergency Care;Health Services;Patient Safety

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Older adults (≥65 years old) are at the greatest risk of adverse drug events (ADEs) induced by anticoagulants, antidiabetic agents and opioids; these ADEs account for nearly 60% of all ADE-related emergency department visits. High-order drug-drug interactions, i.e. the concurrent use of ≥3 drugs is a major risk factor of these ADEs and is most prevalent among older adults. Knowledge on the safety of the concomitant use of ≥3 drugs is critical for preventing serious ADEs among older adults.

PI_NAMEs: DONNEYONG, MACARIUS M. (contact);ZHANG, PENGYUE

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Address;adjudication;Adult;Adverse drug event;Adverse event;Anti-diabetic Drugs;Anticoagulants;Biological;Caring;Cause of Death;Characteristics;Chronic;Clinical;Clonidine;comorbidity;comparative;comparative safety;Data;data mining;Databases;design;Development;Diagnosis;Drug Combinations;Drug Interactions;Drug Kinetics;drug misuse;Drug usage;Electronic Health Record;Emergency department visit;Exposure to;Fluconazole;frailty;Future;Gastrointestinal Hemorrhage;Goals;Health;health care service utilization;health data;Healthcare Systems;High Prevalence;high risk;Hospitalization;Hospitals;Human;human old age (65+);Hypoglycemia;Impaired cognition;Indiana;Individual;insurance claims;interest;Knowledge;Literature;Measures;Medicare;Methods;Modeling;Myopathy;Ohio;older adult;older patient;Omeprazole;Opioid;patient population;patient safety;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacokinetic model;pharmacologic;Pharmacy facility;physiologically based pharmacokinetics;Polypharmacy;Population;population based;prevent;Prevention;Procedures;Provider;Public Health;Publishing;Recommendation;Research;Research Design;response;Review Committee;Risk;Risk Factors;Safety;safety assessment;Services;synergism;Techniques;Therapeutic;tool;Training;Treatment outcome;Visit;young adult

PROJECT_TITLE: Significant high order drug interactions in the emergency department setting among older patient population

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Primary open angle glaucoma (POAG) causes permanent loss of vision and is a condition of public health significance worldwide, affecting millions of people. The etiology of POAG is poorly understood and effective means of primary prevention and curative therapies are not available. In this proposal, our collaborative consortium will complete genetic studies to identify risk factors for POAG and the normal tension subgroup with the ultimate goals of developing effective screening and prevention strategies and novel therapies targeted to the molecular events responsible for the disease.

PI_NAMEs: WIGGS, JANEY L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Age;age related;biobank;Biological;Biological Process;Blindness;Candidate Disease Gene;Caucasians;Cellular Assay;Clinical Data;ClinVar;Code;cohort;Communication;Complex;curative treatments;Data;Data Analyses;data integration;Databases;dbSNP;Development;Diagnosis;Disease;Drug Targeting;Ensure;Etiology;European;Event;exome;exome sequencing;Functional disorder;Funding;Gene Frequency;Genes;Genetic;genetic architecture;Genetic study;genetic variant;genome wide association study;genomic data;Genomics;Glaucoma;Goals;Heritability;Individual;insertion/deletion mutation;insight;interest;Joints;Logistic Regressions;Measurement;Methods;modifiable risk;Molecular;mouse model;Neighborhoods;Nerve Degeneration;neuroprotection;new therapeutic target;Normal Range;novel;novel therapeutics;Optic Nerve;optic nerve disorder;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Physiologic Intraocular Pressure;Population;Predisposition;Prevention strategy;Prevention therapy;Primary Open Angle Glaucoma;Primary Prevention;Process;Protein Truncation;Public Health;Quality Control;rare variant;Regulation;Research;Research Personnel;Resources;Retinal Ganglion Cells;Risk Factors;risk variant;Sampling;screening;single cell sequencing;Single Nucleotide Polymorphism;Subgroup;Testing;Therapeutic;therapeutic target;Tissues;trait;transcriptome;Variant;Visual Fields;web platform;Zebrafish

PROJECT_TITLE: NEIGHBORHOOD Consortium for POAG Genetics


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The dynamics of cerebral blood flow are important in many clinical scenarios including acute stroke (infarct evolution, hemorrhage), traumatic brain injury, and preterm birth (hypoxic- ischemic injury). Real time maps of cerebral blood flow at the bedside are therefore a long sought after assay for neuro-critical care. This grant will develop speckle contrast optical tomography (SCOT) for imaging of cerebral blood flow dynamics in humans.

PI_NAMEs: CULVER, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;acute stroke;Algorithms;Anatomy;arterial spin labeling;artery occlusion;Biological Assay;Blood flow;Brain;Brain region;Calibration;Caring;Carotid Arteries;Cephalic;cerebral autoregulation;cerebral hemodynamics;cerebrovascular;Cerebrovascular Circulation;cerebrovascular reactivity;Clinical;cranium;Data;data quality;density;detector;Development;Diameter;Diffuse;diffuse optical tomography;Diffusion;Edema;Event;Evolution;experience;Fiber;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Grant;Head;Hemoglobin;Hemorrhage;Hour;Human;hypoxic ischemic injury;Image;imaging approach;imaging modality;Impairment;imprint;improved;in vivo;indexing;Infarction;instrumentation;Intracranial Pressure;Ischemia;Ischemic Stroke;Laser-Doppler Flowmetry;Lasers;Light;Magnetic Resonance Imaging;Maps;Measurement;Measures;meter;Methods;Modality;Modeling;Modernization;Monitor;Morphologic artifacts;Motion;Near-Infrared Spectroscopy;neuroimaging;Neurology;Noise;optical imaging;Optical Tomography;Optics;Patients;Pattern;Perfusion;Photic Stimulation;Photons;Positron-Emission Tomography;post stroke;Premature Birth;Rattus;reconstruction;Research;Resolution;respiratory challenge;Scalp structure;sensor;Signal Transduction;Source;spatiotemporal;Specificity;Spectrum Analysis;Speed;statistics;stroke patient;System;Technical Expertise;Techniques;Time;Tissues;tomography;Translating;Traumatic Brain Injury;Work

PROJECT_TITLE: High Sensitivity Diffuse Optical Tomography of Human Brain Funciton

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Many diseases of the nervous system, including neurodegenerative diseases and behavioral disorders, affect males and females differently. Using a genetic model system, these studies will identify molecular and cellular mechanisms by which the sex of an individual influences the development and function of the nervous system. These results will provide a framework for understanding similar processes in humans, which could explain the basis for sex-specific susceptibility or resistance to a variety of disorders of the nervous system.

PI_NAMEs: PORTMAN, DOUGLAS S (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;Animals;Behavior;Behavior Disorders;Behavioral;Biological Models;biological sex;Brain;Caenorhabditis elegans;Cells;Complement;Complex;Decision Making;Development;dimorphism;FarGo;Female;flexibility;Genetic;Genetic Models;Human;Individual;insight;male;Molecular;Nematoda;Nervous System;Nervous System Disorder;Nervous System Physiology;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Neurons;neuropsychiatric disorder;novel;Physiological;Physiology;Predisposition;Process;programs;Research;Resistance;Role;Sensory;sensory integration;sex;Signal Transduction;Tissues;Untranslated RNA

PROJECT_TITLE: Biological Sex as a Modulator of Neuronal Development and Function

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Tactile aids help people with low vision or blindness maintain independence, but tactile aids remain limited in what they can display because most tactile aids transmit information in a similar way: by using a mixture of bumps, lines, or textures. The proposed work will deliver several designer materials which can create a variety of new tactile sensations by using phenomena from materials chemistry. By increasing variety and control, these designer materials will improve the quality of tactile aids and make it easier to display mathematical concepts, play complex board games, and reduce the burden of everyday activities for people with low vision or blindness.

PI_NAMEs: DHONG, CHARLES B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Creating New Tactile Sensations for Tactile Aids with Designer Materials


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative High-throughput sequencing can be used to measure many types of biochemical activity along the genome in a huge variety of primary cell types and cell lines (“biosamples”), but it is prohibitively expensive to measure all possible types of activity in all possible biosamples. Accordingly, we have developed a powerful machine learning approach to predict such measurements before they are performed. Here, we propose to increase Avocado's utility by extending the method to work with single-cell data types, to work with 3D genome architecture data, to incorporate information about DNA sequence and to decode regulatory DNA sequence and non-coding genetic variation.

PI_NAMEs: NOBLE, WILLIAM STAFFORD (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Architecture;Avocado;Awareness;Binding;Biochemical;Biological Assay;biological systems;Cell Line;cell type;Cells;Cellular Assay;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Collection;Complex;Computer software;cost;Couples;Data;data imputation;Data Set;data standards;deep neural network;Disease;DNA;DNA Methylation;DNA Sequence;DNA sequencing;Epigenetic Process;Evaluation;experimental study;Future;Gene Expression;genetic manipulation;Genetic Transcription;Genetic Variation;Genome;genome-wide;genomic data;genomic locus;Genomics;Genotype-Tissue Expression Project;Goals;Health;Hi-C;High-Throughput Nucleotide Sequencing;histone modification;Human;improved;in silico;Individual;Internet;invention;Investigation;Joints;large datasets;Learning;Machine Learning;Measurement;Measures;Methodology;Methods;Methylation;model organism;Modeling;Molecular;next generation;open source;Pattern;Positioning Attribute;predictive modeling;Process;Property;Regulatory Element;Resolution;Resources;Sampling;Scientist;syntax;System;Techniques;Technology;Tissues;Training;transcription factor;United States National Institutes of Health;Untranslated RNA;Validation;Variant;web portal;Work

PROJECT_TITLE: Deep tensor genomic imputation

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetic Testing;Genetics;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE We propose to develop a novel screening strategy to detect patients at high-risk for developing pancreatic cancer at least 6 months prior to the development of symptoms. The approach is based on following innovative premises: (i) using urine biomarkers to better enrich the screening population, and thereby, identify the subset of patients in whom more expensive and invasive surveillance strategies are warranted, which should significantly reduce pancreatic cancer mortality and patient care costs; (ii) using urine exosomes rather than total urine for some tests to further concentrate disease specific biomarkers, and (iii) using samples collected before diagnosis in prospective studies.

PI_NAMEs: BATRA, SURINDER K.;BRAND, RANDALL ;LOKSHIN, ANNA E. (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Accounting;Algorithms;Benign;Biological Markers;biomarker panel;Blinded;Body Fluids;Cancer Etiology;candidate marker;care costs;Cessation of life;Chinese;Classification;Clinical;clinical diagnosis;Clinical Research;clinical translation;cohort;Cohort Studies;combinatorial;Communities;cost;Curative Surgery;Data;Death Rate;Development;Diagnosis;Diagnostic;Differential Diagnosis;Discrimination;Disease;early detection biomarkers;Early Diagnosis;Environment;Excision;exosome;Future;General Population;Genes;Goals;Health;high risk;high risk population;improved;Incidence;Individual;innovation;Institution;Intervention;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Minority;mortality;novel;novel diagnostics;Nurses' Health Study;Operative Surgical Procedures;Organ;Outcome;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pathology;Patient Care;patient subsets;Patients;Performance;Persons;Phase;Population;Probability;Prognosis;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;protein biomarkers;Proteins;Research;Resectable;Retrospective cohort;Risk;Risk Assessment;Sampling;screening;screening guidelines;Sensitivity and Specificity;Serum;Singapore;Site;Source;specific biomarkers;Specificity;surveillance strategy;Survival Rate;Symptoms;Testing;Training;Translations;tumor;urinary;Urine;Validation;Work

PROJECT_TITLE: Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Adenovirus Is the most common cause of human eye infection; corneal inflammation from the infection can persist and recur for years, even when the infection has resolved and the virus is no longer present. We have identified a chronically altered inflammatory milieu in the post infected cornea, evident by the persistence of infiltrating immune cells and pro-inflammatory proteins. In this application, we will explore the mechanisms of chronic corneal inflammation after adenovirus infection in vivo, with the goal to develop evidence-based treatments to prevent vision loss.

PI_NAMEs: CHODOSH, JAMES  (contact);RAJAIYA, JAYA

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Accounting;Acute;acute infection;Address;Adenovirus Infections;Adenoviruses;Affect;ATAC-seq;Blindness;bodily sensation;Capsid;Cell Lineage;cell type;Cells;Chemical Modifier;chemokine;Chromatin;Chronic;chronic inflammatory disease;Clinical;Clinical Trials;Conjunctivitis;Cornea;Corneal Stroma;cost;cytokine;Data;design;DNA;Effector Cell;Enzyme-Linked Immunosorbent Assay;Epidemic Keratoconjunctivitis;Epigenetic Process;Epithelium;Etiology;Evidence based treatment;Eye Infections;Flow Cytometry;Foreign Bodies;Goals;Human;human pathogen;Immune;immune cell infiltrate;immune imaging;Immunologic Memory;In Situ;in vivo;Individual;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Innate Immune Response;Keratitis;Kinetics;Location;Macrophage;Malignant Neoplasms;Mediator;MHC Class II Genes;Modeling;Modification;Molecular;Monitor;monocyte;mouse model;Mus;Myelogenous;Natural Immunity;Natural Killer Cells;neutrophil;ocular surface;Office Visits;Pathologic;Pattern;Persons;Phenotype;Photophobia;prevent;Primary Care;Protein Array;Proteins;Public Health;Recurrence;Resolution;response;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Stromal Cells;Testing;therapy development;Time;Topical Corticosteroids;Training;transcriptome;United States;Variant;Viral;Viral Antigens;viral DNA;Virulent;Virus;Virus Diseases;Visual impairment

PROJECT_TITLE: Immunopathogenesis of Adenovirus Keratitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Understanding the brain mechanisms of learning would have important implications in neural disorders such as Alzheimer's disease, dementia, Parkinson's disease and ADHD. We propose a series of experiments to study detailed neural circuit mechanisms mediating motor learning using cutting-edge tools in mice.

PI_NAMEs: KOMIYAMA, TAKAKI  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;age related;aging related;Alzheimer's Disease;Animals;Area;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Data;Dementia;Dendritic Spines;Diagnosis;Diagnostic;Disease;Environment;excitatory neuron;Excitatory Synapse;Exhibits;experience;experimental study;Forelimb;frontier;Functional Imaging;Goals;Head;Human;Image;imaging properties;improved;in vivo two-photon imaging;innovation;Joystick;Knowledge;Learning;Learning Disorders;Maps;Mediating;Memory;Modification;Motor;motor behavior;motor control;Motor Cortex;motor disorder;motor learning;Movement;Mus;neural;neural circuit;Neurons;novel;optogenetics;Parkinson Disease;Pattern;Performance;Personal Satisfaction;Phase;Population;postsynaptic neurons;Process;programs;Publications;rehabilitation strategy;Research;Resolution;sample fixation;serial imaging;Series;Specificity;Stroke;Synapses;Synaptic plasticity;Technology;Testing;Time;tool;Training;two-photon

PROJECT_TITLE: Cortical Control of Motor Learning

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE This two site study will assess, in the R61 phase, the dose-dependent effects of the transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light in major depressive disorder (MDD), using the increase in brain blood-oxygenation-level dependent (BOLD) signal as Go/No-go target engagement biomarker. In the R33 phase, we will study repeated administrations of t-PBM versus sham in MDD, to establish the target engagement and evaluate the association between changes in the biomarker and changes in clinical symptoms, while also collecting important information on antidepressant effects, safety and tolerability. This will be a key first step to developing a novel, easy to administer neuromodulation treatment for MDD.

PI_NAMEs: CASSANO, PAOLO ;IOSIFESCU, DAN VLAD (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: absorption;acute stroke;Adenosine Triphosphate;Adoption;Affect;Aftercare;American;Anesthesia procedures;Animal Model;antidepressant effect;Bilateral;Biological Markers;biomarker development;blood oxygen level dependent;Brain;Cephalic;Cerebral cortex;Cerebrovascular Circulation;Clinical;clinical development;cost;cytochrome c oxidase;Data;depressive symptoms;Devices;disability;Disease;Dose;Double-Blind Method;Drug Prescriptions;effective therapy;Electroconvulsive Therapy;Electrodes;Electroencephalography;Enzymes;experience;Exposure to;FDA approved;Feeling suicidal;Forehead;Frontal gyrus;Functional Magnetic Resonance Imaging;Future;General Hospitals;Generations;Goals;Grant;healthy volunteer;Home;Human;Infrared Rays;Intervention;Lasers;Light;Literature;Major Depressive Disorder;Massachusetts;Measures;Medial;Mental Depression;Mitochondria;Mood Disorders;neuroregulation;New York;novel;Operative Surgical Procedures;Patients;Penetration;Pharmaceutical Preparations;Phase;photobiomodulation;Phototherapy;Pilot Projects;Positioning Attribute;Prefrontal Cortex;Production;Psychotherapy;Randomized;randomized, clinical trials;repetitive transcranial magnetic stimulation;Reporting;research clinical testing;Resistance;Respiratory Chain;Safety;Sample Size;Self Administration;Self Management;side effect;Signal Transduction;Site;stroke patient;suicidal behavior;Symptoms;targeted biomarker;Testing;Time;Universities;user-friendly;vagus nerve stimulation

PROJECT_TITLE: Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Precision Medicine;Women's Health Research

PHR: This proposal involves the creation of a new generation of microfluidic devices, capable of processing the entire volume of leukapheresis product (65 mL) to sort large numbers of circulating tumor cells, which can then be rapidly expanded ex vivo, to enable real-time and personalized functional testing of drug sensitivity in patients with metastatic breast cancer patients receiving therapies for which predictive markers are insufficient.

PI_NAMEs: HABER, DANIEL A.;MAHESWARAN, SHYAMALA ;TONER, MEHMET  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: acquired drug resistance;Active Sites;Antibodies;antibody conjugate;Antibody-drug conjugates;Biological;Biomedical Engineering;Biopsy;Blood;Blood Cells;Blood Platelets;blood product;Blood Screening;Blood Volume;Breast;Breast Cancer Patient;Breast Cancer therapy;cancer care;cancer cell;cancer invasiveness;Cancer Patient;cancer therapy;Cell Count;Cell Separation;Cell surface;Cells;checkpoint therapy;Circulation;Clinical;clinical application;Complex;Cultured Tumor Cells;design;DNA;DNA Sequence Alteration;drug development;drug sensitivity;drug testing;Epitopes;Excision;Generations;Genetic;Goals;Hematopoietic stem cells;high throughput technology;Hour;Hypoxia;Immunologics;immunosuppressed;Immunotoxins;individual patient;individualized medicine;insight;Lesion;Leukapheresis;Leukocytes;liquid biopsy;magnetic beads;Magnetism;Malignant Neoplasms;Measures;Metastatic breast cancer;Microfluidic Microchips;microfluidic technology;Microfluidics;Molecular;molecular subtypes;Monitor;multidisciplinary;Mus;Mutation;Mutation Analysis;Needles;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Patient Selection;patient subsets;Patients;PD-1/PD-L1;Performance;Peripheral Blood Mononuclear Cell;personalized cancer care;Pharmaceutical Preparations;Plasma;Population;Population Heterogeneity;pre-clinical;precision oncology;predictive marker;Primary Neoplasm;Procedures;Process;Prognosis;Property;Reporting;Resistance;response;Sampling;Sampling Biases;Selection for Treatments;small molecule inhibitor;Solid Neoplasm;Sorting;stemness;Stream;success;TACSTD1 gene;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Burden;Tumor Markers;Tumor-Derived;tumorigenic;Whole Blood;Woman

PROJECT_TITLE: High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Glaucoma is a chronic disease that leads to loss of vision following death of a specific cell in your retina, called a "retinal ganglion cell". Our research has identified a signaling pathway that is triggered during glaucoma that causes the death of these cells and we are studying the mechanisms by which this pathway causes death of these cells with the goal of developing novel targeted therapies for patients with glaucoma.

PI_NAMEs: GREGORY-KSANDER, MEREDITH  (contact);MARSHAK-ROTHSTEIN, ANN

PROJECT_TERMS: Acceleration;Address;Apoptosis;Apoptotic;Astrocytes;Binding;Blindness;Cause of Death;CD95 Antigens;Cell Death;cell type;Cells;Cessation of life;chemokine;Chimera organism;Chronic Disease;constitutive expression;cytokine;Dangerousness;Data;Defect;Development;Disease;Effector Cell;Embryo;Environment;Equilibrium;Extracellular Domain;Eye;Eye diseases;Family;Fluorochrome;Gene Expression;Gene Targeting;Genetic Transcription;Glaucoma;Glial Fibrillary Acidic Protein;Goals;Grant;Homeostasis;Immune;improved;inducible Cre;Infiltration;Inflammation;Inflammatory;Injections;insight;Integral Membrane Protein;intravitreal injection;Length;Ligands;Link;macroglia;Mediating;Mediator;Membrane;membrane activity;Metalloproteases;Microspheres;Modeling;Monitor;Morula;Muller's cell;Mus;Mutate;Mutation;Neuroglia;neurotoxic;new therapeutic target;novel;Ocular Pathology;Onset of illness;Optic Disk;Optic Nerve;Outcome;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;prevent;Prevention;Process;Production;programs;Protein Isoforms;Proteins;receptor;recruit;Regulation;Research;Retina;Retinal Ganglion Cells;Role;Signal Pathway;Signal Transduction;Site;sortase;Source;systemic autoimmune disease;Tamoxifen;Therapeutic;therapeutic target;Time;TIMP1 gene;Tissue Inhibitor of Metalloproteinase-1;Tissues;TNF gene;tool;Transfection;Tumor Necrosis Factor Ligand Superfamily Member 6;Vascular Endothelial Cell;vector

PROJECT_TITLE: Fas Ligand Cleavage regulates ocular homeostasis and glaucoma


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Molecular chaperones rescue non-native proteins from aggregation and misfolding and are thus central to maintaining a functional proteome in the cell. Protein kinases regulate almost every aspect of cellular function, including cell growth, proliferation, differentiation, metabolism, migration, and death. Both protein families are targets for therapeutic intervention.

PI_NAMEs: KALODIMOS, CHARALAMPOS  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Architecture;Biochemical;biophysical techniques;BRAF gene;cell growth;Cell Physiology;Cells;Cessation of life;Client;Complex;Cytoplasm;Family;Goals;Human;Human Genome;Hyperactivity;Malignant Neoplasms;member;Metabolism;migration;Molecular Chaperones;Molecular Conformation;Molecular Structure;Mutate;NMR Spectroscopy;non-Native;novel;Phosphotransferases;Proliferating;protein aggregation;Protein Dynamics;Protein Family;Protein Kinase;Protein Tyrosine Kinase;Proteins;Proteome;prototype;raf Kinases;Reporting;Resolution;Role;Signal Pathway;Structure;targeted treatment;Therapeutic Intervention;tumor;Work

PROJECT_TITLE: Structure and functional mechanisms of molecular chaperones and protein kinases


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Activities required for daily living usually involve planning and executing long sequences of movements, which are orchestrated through interactions between a large group or cortical and sub-cortical brain structures. Unfortunately, the ability to perform such movement sequences is significantly compromised as a result of neurological disease and/or injury (e.g., Parkinson’s, dystonia, and amyotrophic lateral sclerosis, etc.). This project aims to understand the neural computations and mechanisms of three key brain regions, including their interactions, which drive movements over long timescales.

PI_NAMEs: VYAS, SAURABH  (contact)

PROJECT_TERMS: Activities of Daily Living;Affect;Algorithms;Amyotrophic Lateral Sclerosis;Area;arm;Behavior;Brain;Brain region;Clinical;Cognitive;Communication;Complex;computer studies;Data;Data Analyses;Deep Brain Stimulation;design;dimension reduction;Dimensions;Disease;Dorsal;dynamic system;Dystonia;Electrodes;Electrophysiology (science);Engineering;Excision;Feedback;Goals;Hygiene;Investigation;Knowledge;Measurement;Mentors;Methods;Modernization;Motor;motor control;Motor Cortex;Motor Neurons;Movement;Movement Disorders;multidimensional data;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Nervous System Trauma;network models;neural;Neural Network Simulation;neural prosthesis;Neurons;Neurosciences;nonhuman primate;Outcome;Output;Parkinson Disease;physical science;Population;Population Analysis;Population Dynamics;Prefrontal Cortex;Privatization;Process;Production;Property;Prosthesis;recurrent neural network;Research;response;segregation;Series;Signal Transduction;Site;Specific qualifier value;Sterile coverings;Structure;success;System;Testing;theories;therapeutic development;Time;tool;Tooth structure;Training;transmission process;Universities;Work

PROJECT_TITLE: Cortical Computations Underlying Planning, Generating, and Orchestrating Complex Cognitive-Motor Sequences

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Current approaches for tumor prognosis and treatment monitoring is poor. The application may shift the current paradigm of imaging tumor because it is expected to result in a high sensitive MRI method for measuring altered membrane choline phospholipids and their metabolism which are strongly associated with upregulated proliferation rate, a main feature of aggressive tumor.

PI_NAMEs: ZU, ZHONGLIANG  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Acceleration;Animals;Biological Process;Biomass;cancer cell;cancer diagnosis;cancer imaging;Cell membrane;Cell Proliferation;Cells;Cellular Structures;Chemicals;Choline;Clinical Research;Coupling;Data;Detection;Deuterium;Early Diagnosis;Enzymes;Fatty Acids;Frequencies;Goals;Growth;Head;high resolution imaging;Human;Image;Image Enhancement;imaging approach;imaging modality;improved;in vivo;Invaded;Lipids;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Maps;mass spectrometric imaging;Measures;Mediating;Membrane;metabolic imaging;Metabolism;Methods;methyl group;Modeling;molecular imaging;Monitor;Neoplasm Metastasis;Nervous System Disorder;novel;nuclear Overhauser enhancement;Phospholipase;Phospholipid Metabolism;Phospholipids;Physiologic pulse;preclinical study;Prognosis;Proliferating;Protons;Resolution;Sampling;Scanning;Side;Signal Transduction;Slice;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrum Analysis;Tail;Techniques;Time;Tissues;tumor;tumor diagnosis;Validation;Water

PROJECT_TITLE: Nuclear Overhauser enhancement (NOE) MR imaging of choline phospholipids and their metabolism

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The youngest victims of the opioid crisis are infants. Using a 3-trimester opioid exposure paradigm we have developed an animal model of Neonatal Opioid Withdrawal Syndrome (NOWS) that recapitulates robust withdrawal symptoms of relevant withdrawal behaviors in infants. We will use this model to identify underlying cellular and molecular mechanisms that may lead to new therapeutics.

PI_NAMEs: BLENDY, JULIE A (contact);EHRLICH, MICHELLE E

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Adenine;Adult;Affect;Affinity Chromatography;Alleles;Animal Model;Anti-Inflammatory Agents;Area;Behavior;Behavioral;Biological Assay;Biological Response Modifiers;Brain region;Breeding;Canis familiaris;Cells;Clinical;complement system;Complex;Crying;cytokine;Data;Development;Diarrhea;Distress;Early Diagnosis;Early treatment;Enterobacteria phage P1 Cre recombinase;Environment;Exhibits;experience;experimental study;Exposure to;gastrointestinal;gene discovery;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genomic variation;Genomics;Genotype;glial activation;Guanine;Heroin;high risk;Hospitals;Hour;Human;Immune;Immune response;Immunosuppression;in utero;Infant;Inflammatory;Innate Immune Response;Innate Immune System;insight;interest;Length of Stay;Life;Link;Lymphokines;Measures;Mediating;Messenger RNA;Methadone;Microglia;midbrain central gray substance;Modeling;Molecular;molecular marker;Morphine;mouse model;mu opioid receptors;Mus;Natural Immunity;Neonatal;Neonatal Abstinence Syndrome;neonate;Neuroimmune system;neuroinflammation;neuronal cell body;new technology;Newborn Infant;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;Opioid Receptor;opioid use;opioid withdrawal;Pain;Pathway interactions;Perinatal Exposure;Peripheral;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Polypharmacy;Pregnant Women;Presynaptic Terminals;Public Health;pup;Receptor Cell;Receptor Gene;Regulation;response;Ribosomes;Risk;Role;Seizures;Severities;Single Nucleotide Polymorphism;Sleeplessness;Syndrome;Testing;Therapeutic;Time;Tooth structure;transcriptome;Translating;Tremor;United States;Weight Gain;Wild Type Mouse;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Neonatal Opioid Exposure and Withdrawal: Molecular and Behavioral Consequences

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Nanotechnology;Neurosciences;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: The experiments in this proposal focus on developing a new Cas9 delivery vehicle termed CRISPR-PEG. CRISPR-PEG is designed to edit large volumes of brain tissue and in this proposal we will use it to treat mouse models of fragile X syndrome and related disorders. If successful, the experiments in this proposal will develop a new strategy for treating genetic disorders.

PI_NAMEs: LEE, HYE YOUNG  (contact);MURTHY, NIREN

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Address;Advanced Development;base editing;Beds;Behavior assessment;behavior test;behavioral phenotyping;biomaterial compatibility;Brain;Brain Diseases;Brain region;brain tissue;brain volume;Cells;CGG repeat expansion;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Corpus striatum structure;CRISPR therapeutics;CRISPR-nanoparticles;delivery vehicle;demethylation;design;Diffuse;Diffusion;Disease;DNA Damage;Etiology;experimental study;Exposure to;FMR1 gene;Formulation;Fragile X Syndrome;Gene Expression;gene-editing approach;Genes;Genetic;Genetic Diseases;Genomic DNA;Gold;Hypermethylation;immunogenicity;improved;in vivo;in vivo evaluation;Inherited;Injections;innovation;Intellectual functioning disability;Intranasal Administration;knock-down;Knock-in Mouse;Length;Morphology;Motor Cortex;mouse model;Mus;nanoGold;nanoparticle;Neuronal Differentiation;Neurons;Neurosciences;neurotoxicity;novel;olfactory bulb;Other Genetics;patient derived induced pluripotent stem cells;Patients;Phenotype;Polyethylene Glycols;promoter;Promoter Regions;Proteins;Publishing;Reagent;repetitive behavior;restoration;Ribonucleoproteins;Signal Transduction;Solubility;Specificity;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Transfection;translational impact;translational potential;Variant;Vertebral column;Viral

PROJECT_TITLE: Gene editing in the brain with CRISPR-PEG

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: An improved understanding of different pathways used in metastasis will provide opportunities to slow the spread of high-grade serous ovarian cancer (HGSOC), improving patient prognosis and quality of life. In HGSOC, metastasis results from individual cells and aggregates of cells that break free from a tumor site, float through the peritoneum, and reattach in a new site. We hypothesize that single cell and aggregate- based metastasis are distinct processes and will test this hypothesis through analysis of patient samples, computational simulations of single cell and aggregate movement through the peritoneum, and experimental tests in vitro and in vivo.

PI_NAMEs: KREEGER, PAMELA K (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adhesions;Age;Anatomy;Anoikis;Ascites;Biological;Biology;Biomimetics;cancer cell;cancer diagnosis;Cell Aggregation;Cell-Cell Adhesion;Cells;Cellular Assay;Clinical;Computer Simulation;Data;Detection;Diagnosis;Disease;Elements;Engineering;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Future;Greater sac of peritoneum;improved;In Vitro;in vitro testing;in vivo;Individual;Integrins;intraperitoneal;Liquid substance;Malignant neoplasm of ovary;Malignant Neoplasms;Mechanics;Mesothelial Cell;Mesothelium;meter;Methods;Modeling;Molecular;Motion;mouse model;Movement;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;Ovary;palliation;Pathologic;Pathway interactions;patient prognosis;patient variability;Patients;Pelvis;Peritoneal;Peritoneal Fluid;Peritoneum;Primary Neoplasm;Process;Prognosis;Progression-Free Survivals;Quality of life;Race;Resistance;Respiratory Diaphragm;response;Role;Sampling;Selectins;Serous;shear stress;simulation;Site;Solid Neoplasm;spheroids;surgery outcome;Survival Rate;System;Testing;Therapeutic;Tissues;tumor;tumor growth;tumor microenvironment;tumor progression;Variant;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Impaired red cell differentiation is associated with may hematologic disorders. Autophagy promotes red cell production by facilitating the clearance of organelles and macromolecules. Understanding the regulation of autophagy in normal and impaired erythropoiesis may provide new targets for therapeutic intervention.

PI_NAMEs: STOLLA, MASSIEL CHAVEZ (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Acetylcysteine;Antioxidants;Autophagocytosis;Autophagosome;BCL-2 Protein;BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like;Biology;Cell Differentiation process;Degradation Pathway;Development;Disease;Dysmyelopoietic Syndromes;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;experimental study;Ferritin;Genes;Hematological Disease;Hematology;Hematopoietic;Heme;Hemoglobin;Human;human induced pluripotent stem cells;human model;Impairment;improved;in vivo;induced pluripotent stem cell;inhibition of autophagy;International;Investigation;Iron;K-Series Research Career Programs;Knowledge;Laboratories;macromolecule;Mammalian Cell;Measures;Mediating;Mentorship;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;model organism;mouse model;new therapeutic target;Organelles;oxidation;Oxidative Stress;Patients;Peptide Hydrolases;Preparation;Production;progenitor;Proteins;Reactive Inhibition;Reactive Oxygen Species;receptor;recruit;Regulation;Reporter;Research Personnel;Role;selective expression;Sideroblast;stem cell model;TFRC gene;Therapeutic Intervention;Tissues;Training;Universities;Washington

PROJECT_TITLE: Investigation into the role of autophagy protease ATG4A in normal and impaired erythropoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Sleep Research;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Obesity, especially among young children, is a serious danger to the current and future health of America and understanding what personal and environmental factors influence obesity development are crucial to reversing the current obesity epidemic. This study will examine how two understudied factors, sleep-wake patterns and the gut microbiome, affect rapid weight gain in infancy, an early risk factor for obesity. The development of sleep-wake patterns and gut microbe communities will be evaluated, in the context of diverse feeding, maternal, and environmental influences, on infant weight gain.

PI_NAMEs: PETROV, MEGAN ELISE (contact);WHISNER, CORRIE MARIE

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: 16S ribosomal RNA sequencing;3 year old;actigraphy;Adult;Affect;Age;aged;American;Animals;Antibiotics;Bacteroides fragilis;beneficial microorganism;Bifidobacterium;biobehavior;Birth;Breast Feeding;Cardiometabolic Disease;Cesarean section;Characteristics;Child;Child Health;circadian;Circadian desynchrony;Clinical;Clinical Trials;Community Developments;Data;Development;disorder risk;early childhood;Ecology;Energy harvesting;Environmental Risk Factor;Epidemiology;ethnic diversity;evidence based guidelines;Evidence based practice;Exhibits;experience;Family;feeding;Firmicutes;Future;Genus staphylococcus;Growth;Growth Factor;gut microbiome;gut microbiota;Health;Home visitation;Homeostasis;Human;improved;infancy;Infant;infant adiposity;infant gut microbiome;Intervention;Life;Longitudinal, observational study;Low income;Mediator;Metabolic;Metabolic Pathway;Metabolism;microbiome alteration;microbiome research;Modeling;Mothers;Neurologic;novel;Obesity;obesity development;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;Outcome;pathogen;Pattern;Periodicity;poor sleep;Pregnancy;prenatal;prepregnancy;prevent;Prevention;prospective;racial diversity;rapid infant weight gain;rapid weight gain;Regulation;Risk;Risk Factors;Risk Reduction;Role;role model;Route;Shapes;Signal Transduction;Sleep;sleep quality;Staphylococcus aureus;Stimulus;Testing;therapy design;Time;time interval;time use;Vagina;Weight;Weight Gain;Work;World Health Organization

PROJECT_TITLE: Investigating the Influences of Sleep‐Wake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Diabetes;Infectious Diseases;Nanotechnology;Prevention;Regenerative Medicine;Wound Healing and Care

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Chronic nonhealing wounds are debilitating with high morbidity and mortality. It is widespread and costly to treat (e.g. ~ $15 billion/year for venous leg ulcers in the United States alone). The proposed research project is aimed to develop a multifunctional patch with a unique capacity to resume bodies' capacity to heal chronic wounds.

PI_NAMEs: MAHMOUDI, MORTEZA  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Address;Affect;Amputation;angiogenesis;Anti-Bacterial Agents;Antibiotic Resistance;Automobile Driving;Bacterial Infections;Blood Vessels;Cell Proliferation;Cells;Chitosan;Chondroitin Sulfates;Chronic;chronic wound;Cicatrix;Clinical;clinically relevant;clinically significant;Coculture Techniques;Collagen;Complex;cost;design;Development;Devices;Diabetic Foot Ulcer;diabetic rat;diabetic ulcer;Ecosystem;effective therapy;Electron Microscopy;Environment;Epithelium;experimental study;Exposure to;Exudate;FDA approved;ferumoxytol;Follistatin;Foot Ulcer;Foundations;Funding;Goals;healing;Hyaluronic Acid;Immune response;Immune system;immunodeficiency;Impaired healing;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Infection;Inflammation;Inflammation Mediators;Innovation Corps;Interview;iron oxide nanoparticle;Leg Ulcer;Libraries;Liquid substance;Macrophage;Macrophage Activation;Mammalian Cell;Measures;Medical;Membrane;Metalloproteases;Microbial Biofilms;migration;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;nanofiber;nanoparticle;nanoparticle exposure;nanoscale;Nanostructures;Nanotechnology;Natural regeneration;non-healing wounds;novel;Patch Tests;Pathway interactions;Patients;Peptides;Polymers;Polysaccharides;Predisposition;prevent;Prevention;Process;programs;Proliferating;Property;Proteins;Rattus;repaired;Research;Research Project Grants;risk minimization;Role;scaffold;Science;Site;Skin;skin damage;skin patch;Social Responsibility;Staphylococcus aureus;Sterile coverings;success;superparamagnetism;Surface;System;Testing;Therapeutic;therapeutic patch;Tissue Engineering;Tissues;Treatment Efficacy;United States;Venous;wound;wound closure;wound dressing;wound environment;wound healing;Wound healing therapy;Wound Infection

PROJECT_TITLE: A Nanostructured Skin Patch to Heal Chronic Wounds

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: CAPE TOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: DESMOND TUTU HIV FOUNDATION

PHR: PROJECT NARRATIVE This prospective study will increase our understanding of the social determinants, with an emphasis on TB- and HIV-related stigmas, that influence progression along the TB cascade, from presenting for TB testing (finding the “Missing Cases”) to returning for TB test results (initial loss to follow up), and from retention in TB care to post-treatment TB outcomes in South Africa. Findings from this grant will inform changes to more patient- centered TB screening, treatment, and intervention guidelines in low-middle income countries globally. Results will also inform the development of stigma reduction interventions, as needed.

PI_NAMEs: KIPP, AARON M;MEDINA-MARINO, ANDREW  (contact)

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: Address;Adherence;Aftercare;Articulation;care outcomes;care seeking;Caring;case finding;Cause of Death;Clinic;co-infection;Communities;Community Developments;Continuity of Patient Care;Data;design;Detection;Development;Diagnosis;Diagnostic;Discrimination;Disease;effective intervention;experience;Family;follow-up;Gender;Grant;Guidelines;Health;Health behavior;HIV;HIV diagnosis;HIV/TB;Household;improved;Incidence;Individual;Institution;internalized stigma;Intervention;lens;Literature;low and middle-income countries;Measures;Methods;Modeling;multilevel analysis;neglect;Outcome;Outcome Study;Participant;patient oriented;Patients;Population;Poverty;Prevalence;programs;prospective;Prospective Studies;Qualitative Methods;Reporting;Research Design;Risk Factors;screening;social;social determinants;social stigma;social structure;South Africa;Stigmatization;Structure;Surveys;Symptoms;System;Test Result;Testing;theories;Time;transmission process;Treatment outcome;tuberculosis treatment;uptake

PROJECT_TITLE: Multi-level and Intersectional Stigma and other Social Determinant Effects on TB Case Detection, Care, and Treatment Outcomes: The MISSED TB Outcomes Study

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging;Cardiovascular;Cerebrovascular;Chronic Pain;Clinical Research;Diabetes;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite being a common and serious complication of diabetes, the pathophysiology of diabetic peripheral neuropathy is not well defined. This project will rigorously characterize the epidemiology and risk factors for diabetic peripheral neuropathy in a large cohort of black and white older adults with type 2 diabetes, with a focus on both traditional vascular and neurological risk factors as well as novel biomarkers that may inform pathophysiology and serve as potential targets for interventions in future studies.

PI_NAMEs: HICKS, CAITLIN WHITNEY (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Address;Adult;Age;Age Years;aged;aptamer;Area;Atherosclerosis Risk in Communities;Biological Markers;biomarker identification;Biometry;Biostatistical Methods;Blood;Blood Vessels;Body mass index;brain magnetic resonance imaging;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;career development;Cerebrovascular Disorders;Cessation of life;circulating biomarkers;Clinical;Clinical Investigator;Clinical Research;clinical risk;clinically relevant;cohort;Cohort Studies;Collaborations;Communities;Complication;Complications of Diabetes Mellitus;Data;Data Collection;Dementia;design;Diabetes Mellitus;diabetes risk;diabetic;Diagnosis;Disease;Doctor of Philosophy;Epidemiologic Factors;Epidemiologic Methods;Epidemiology;epidemiology study;Etiology;Event;experience;Five-Year Plans;follow-up;Foot Ulcer;Functional disorder;Funding;Future;glycemic control;Goals;Hemorrhage;High Prevalence;high risk;human old age (65+);Hypertension;Impaired cognition;improved;Individual;Infarction;insight;Insulin-Dependent Diabetes Mellitus;International;Intervention;Lacunar Infarctions;late life;limb amputation;Link;Lobar;Lower Extremity;Measures;Medical;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Microvascular Dysfunction;middle age;mild cognitive impairment;Morbidity - disease rate;mortality;neglect;Neurologic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;novel strategies;Nucleic Acids;older adult;Older Population;Operative Surgical Procedures;Outcome;Pain;Participant;Pathway interactions;Peripheral arterial disease;Peripheral Nervous System Diseases;Physicians;Plasma;Plasma Proteins;predictive marker;Prevalence;professor;programs;prospective;Prospective cohort;protein biomarkers;protein expression;Proteins;Proteomics;racial disparity;randomized, clinical trials;Research;Research Personnel;Research Proposals;Risk;Risk Factors;Risk Reduction;Sampling;Scientist;sex;skills;Smoking;social;Standardization;Technology;Testing;Training;Triglycerides;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Risk Factors and Outcomes Associated with Late-Life Diabetic Peripheral Neuropathy

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Early human development is a crucial time period in which the structures of primitive streak and extraembryonic mesoderm are formed and errors in cellular differentiation can have dire consequences. This fellowship proposal seeks to advance our fundamental understanding of how human embryonic stem cells decide specific differentiation fates using advanced machine learning methodologies. The findings from this work will help develop future stem cell therapies for treatment of birth defects and miscarriages in early primitive streak and extraembryonic mesoderm formation, ultimately improving public health.

PI_NAMEs: ZIKRY, TAREK  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Affect;Antibodies;Architecture;Behavior;Bilateral;biological systems;Blood Vessels;bone morphogenetic protein 4;Brachyury protein;Cardiovascular system;Cell Cycle;Cell Differentiation process;Cell Lineage;Cell Therapy;cell type;Cells;cellular imaging;Characteristics;Computer Models;Congenital Abnormality;Cues;Data;Data Analyses;Data Set;daughter cell;deep learning;deep learning model;Defect;Dependence;Development;Differential Equation;differentiation protocol;directed differentiation;Ectoderm;effective therapy;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Endoderm;Event;extracellular;Fellowship;fluorescence imaging;Future;gastrulation;Generations;Germ Layers;Goals;Heart;Human;Human body;Human Development;human embryonic stem cell;human imaging;human model;human stem cells;Image;improved;in vitro Model;Individual;Inherited;Live Birth;live cell imaging;Lung;Machine Learning;machine learning method;Mentorship;Mesenchymal Stem Cells;Mesoderm;Mesoderm Cell;Methodology;Methods;Microscopy;migration;Modeling;molecular marker;Monitor;morphogens;Movement;movie;neural network;neural network architecture;novel;Outcome;Pattern;Placenta;pluripotency;Population;Positioning Attribute;precursor cell;Pregnancy;prevent;Prevention;Primitive Streaks;Procedures;Process;Public Health;real-time images;Recording of previous events;recurrent neural network;Regenerative Medicine;repaired;Reporter;Research;Research Training;self organization;self-renewal;Signal Transduction;skills;sound;Specific qualifier value;Spontaneous abortion;Stains;statistical learning;Statistical Methods;stem cell biology;stem cell differentiation;stem cell fate;stem cell therapy;stem cells;Stream;Structure;Surface;System;Time;Tissues;Training;treatment strategy;undergraduate student;Work

PROJECT_TITLE: Deep learning models to predict primitive streak formation in human development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: NARRATIVE: Transplant-related complications including idiopathic pneumonia syndrome (IPS), graft-vs- host disease (GVHD) and veno-occlusive disease (VOD) of the liver are the major contributors to the development of MODS after allogeneic blood and marrow transplantation (BMT) and continue to limit successful outcomes following this otherwise lifesaving procedure. The development of novel strategies to reduce the incidence and severity of these complications or treat the life-threatening aspects of each once established remains one of the most significant challenges facing our pediatric BMT patients. Experiments proposed in this application will enhance our understanding of how inflammation engendered early after transplant contributes to vascular injury and organ dysfunction with great potential to reduce the risk and severity of MODS and improve outcomes for BMT recipients.

PI_NAMEs: COOKE, KENNETH R (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Adhesiveness;Adolescent and Young Adult;Agonist;Allogenic;Angiopoietin-2;ANGPT1 gene;antagonist;Binding Proteins;Biological;Biological Markers;Blood;Blood capillaries;Blood Vessels;Bone Marrow Transplantation;Cell Adhesion Molecules;cell injury;Cell Physiology;Cell surface;Cell Therapy;Cells;Cessation of life;chemokine;Child;Childhood;Clinical;Clinical Data;Clinical Trials;curative treatments;cytokine;Cytotoxic Chemotherapy;Data;Development;dimer;Disease;E-Selectin;Educational workshop;Endothelial Cells;Equilibrium;Etanercept;Evaluation;experimental study;Functional disorder;Funding;graft vs host disease;Human;Idiopathic pneumonia syndrome;Immunologics;improved;improved outcome;Incidence;Inflammation;Inflammatory;Injury;insight;Interleukin-6;Knowledge;Lead;Life;Ligands;Link;Liver diseases;lumican;Lung;lung injury;lung microvascular endothelial cells;Malignant - descriptor;Mediating;Multiple Organ Failure;Mus;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Non-Malignant;novel strategies;Onset of illness;Organ;Outcome;P-Selectin;Pathway interactions;Patients;pediatric patients;Peptides;Plasma;pre-clinical;predicting response;Procedures;Production;Proteins;Proteomics;Pulmonary Inflammation;receptor;Research;Respiratory Failure;Risk Reduction;Role;Sampling;Selectins;Severities;Testing;TIE-2 Receptor;TNF gene;Translational Research;Transplant Recipients;Transplantation;United States National Institutes of Health;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Cell;vascular injury;Veno-Occlusive Disease;Work

PROJECT_TITLE: Inflammatory mechanisms responsible for the development of multiple organ dysfunction in pediatric patients following allogeneic blood and marrow transplantation (BMT).


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: NARRATIVE There is currently no acceptable screening method for ovarian cancer, and most cases are detected when the disease is widespread and likely to be deadly. We will develop a two-step blood-based biomarker followed by a minimally-invasive fallopian tube imaging and sampling technique, as an effective method to detect ovarian cancer at an early time when the disease is most curable.

PI_NAMEs: BARTON, JENNIFER KEHLET (contact);FISHMAN, DAVID A.;LOKSHIN, ANNA E.

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Algorithms;Bilateral;Biological Markers;biomarker validation;Blinded;Blood;Blood Proteins;Blood Screening;Blood specimen;Blood Tests;blood-based biomarker;CA-125 Antigen;Cancer Etiology;Cancerous;Carcinoma;Carcinoma in Situ;cell preparation;Cells;classification algorithm;Clinical;clinically actionable;Collecting Cell;Collection;Data;Detection;Development;Diagnosis;Disease;Early Detection Research Network;Early Diagnosis;Endoscopes;Endoscopy;Epithelial Cells;Epithelial ovarian cancer;Epithelium;Family;Fertility;fluorescence imaging;Genetic;Goals;Greater sac of peritoneum;Health;high resolution imaging;High Risk Woman;Histology;Human;Hysterectomy;Image;Image Analysis;imaging biomarker;Imaging Techniques;improved;in vitro Model;in vivo;Instruction;Lead;Lesion;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Metastatic Malignant Neoplasm to the Ovary;Methods;miniaturize;minimally invasive;Morbidity - disease rate;mortality;Neoplasm Metastasis;Operative Surgical Procedures;optical imaging;Ovarian;Ovarian Serous Adenocarcinoma;Ovary;Patients;Pilot Projects;Predictive Value;premalignant;Procedures;protein biomarkers;Proteomics;prototype;Recommendation;Recording of previous events;Research;Resolution;Risk;Risk Reduction;Salpingo-Oophorectomy;Sampling;screening;Screening for Ovarian Cancer;Sensitivity and Specificity;Serous;Serum;Serum Markers;Serum Proteins;spectrograph;Survival Rate;Symptoms;System;Target Populations;Techniques;Technology;Test Result;Testing;Thinness;Time;Tissues;Transvaginal Ultrasound;Woman;Women's mortality;Women's study;Work

PROJECT_TITLE: Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Patient Safety;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. We propose to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational program that uses continuous glucose monitoring to support older adults at high risk for hypoglycemia. If the aims of this project are achieved, this novel care strategy could be widely applied to reduce severe hypoglycemia episodes in older, high-risk adults with type 2 diabetes.

PI_NAMEs: GRANT, RICHARD W (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Accident and Emergency department;active comparator;Address;Admission activity;Adult;Adverse drug event;Age;Algorithms;American;arm;Blood Glucose Self-Monitoring;California;Cardiovascular system;care delivery;Caring;Cessation of life;Classification;Clinical;clinical effect;Clinical Trials Design;comorbidity;Complication;Continuous Glucose Monitor;Coupled;Dementia;dementia risk;design;diabetes distress;Diabetes Mellitus;Diet;dissemination strategy;Dose;Education;efficacy evaluation;efficacy testing;Electronic Health Record;Emergency department visit;Ethnic Origin;Event;falls;Fingers;Fracture;Fright;Funding;Future;Glucose;glucose monitor;glycemic control;Goals;health literacy;Health Status;Health system;Heterogeneity;high risk;Hospitalization;Human Resources;Hyperglycemia;Hypoglycemia;hypoglycemia unawareness;Iatrogenesis;Impaired cognition;improved;Incidence;Injections;innovation;Insulin;Insurance Carriers;integrated care;Intervention;intervention program;Investments;Measures;Medicare;Modeling;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;older adult;older patient;participant enrollment;Patient Education;patient oriented;patient safety;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Physical activity;Population;Pragmatic clinical trial;pragmatic trial;prevent;programs;Quality of life;Race;Randomized;randomized trial;randomized, clinical trials;Regimen;Research Proposals;Risk;Risk Factors;risk prediction model;Safety;Self Efficacy;Specific qualifier value;statistics;Symptoms;System;Testing;Time;Training and Education;treatment arm;treatment as usual;treatment effect;trend;trial design;Validation;Veterans

PROJECT_TITLE: Pragmatic Clinical Trial of Continuous Glucose Monitoring-based Interventions for Safe Insulin Prescribing in High-Risk Older Patients with Type 2 Diabetes

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

PHR: PROJECT NARRATIVE  The United States (U.S.) is the country with the largest number of infections and deaths due to COVID- 19 and racial/ethnic minorities are disproportionately affected. Acceptance and uptake of COVID-19 vaccines will be instrumental to ending the pandemic. To this end, 2VIDA! (SARS-CoV-2 Vaccine Intervention Delivery for Adults in Southern California) is a multilevel intervention to address individual, social, and contextual factors related to access to, and acceptance of, the COVID-19 vaccine by implementing and assessing a COVID-19 vaccination protocol among Latinx and African American (AA) adults (>18 years old) in San Diego.

PI_NAMEs: SKAATHUN, BRITT  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 18 year old;Acceleration;acceptability and feasibility;Address;Adult;adverse outcome;Affect;African American;Area;Awareness;Behavior;Belief;Biological Factors;California;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Client satisfaction;Communities;community based participatory research;Community Health;Community Outreach;Community Participation;community partners;comparison control;contextual factors;Country;County;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 vaccination;COVID-19 vaccine;Data;demographics;Education;Equity;Essential worker;ethnic minority;evidence base;experience;follow-up;Fright;Genetic;Geographic Locations;Government;Handwashing;Health;health care availability;health care service utilization;health disparity;health disparity populations;Health Promotion;Healthcare;Home;hospitalization rates;Human Rights;Immunization;Immunization Programs;implementation intervention;improved;indicated prevention;Individual;Infection;infection rate;interest;Intervention;intervention delivery;intervention effect;intervention refinement;Knowledge;Latino;Latinx;Latinx population;marginalization;Masks;Medical;Methods;Modeling;Nature;Neighborhood Health Center;Not Hispanic or Latino;Occupations;Outcome;pandemic disease;pandemic impact;Participant;participant retention;people of color;Perception;Persons;Phase;Policies;Population;prevent;Prevention;Preventive;racial minority;racism;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Reporting;Research;Risk;satisfaction;scale up;Series;Services;Site;social;Social Distance;social factors;sociodemographics;standard of care;Strategic Planning;Trust;United States;United States National Institutes of Health;uptake;Vaccination;vaccination protocol;vaccine acceptance;vaccine access;vaccine hesitancy;Vaccines;Virus;Vulnerable Populations;working group;World Health Organization

PROJECT_TITLE: Project 2VIDA! SARS-CoV-2 Vaccine Intervention Delivery for Adults in Southern California

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-G(90)S]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Mitochondrial complex I reactive oxygen species (ROS) production is causally linked to damage in ischemia reperfusion injury, the driving pathology of stroke. Complex I ROS production can also trigger endogenous protective signaling processes, however, and the precise mechanisms governing the physiologic versus the pathologic events are unknown and under studied. We propose to define the mechanisms underlying the apparent duality of ROS by taking unprecedented control of complex I ROS production at a fundamental level to reveal potential mechanisms of damage and recovery in hypoxic pathology.

PI_NAMEs: WOJTOVICH, ANDREW PHILLIP (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Address;Affect;Apoptosis;Automobile Driving;Behavior;Binding Sites;Biochemistry;Bioenergetics;Biological;biological adaptation to stress;Biological Assay;Biology;Biosensor;Blood flow;Brain;Caenorhabditis elegans;Calcium Signaling;career;Cells;Chimeric Proteins;Complex;CRISPR/Cas technology;Data;Disease;Electron Transport;enzyme activity;Event;Exhibits;Generations;Genetic;Genetic Models;Goals;Hypoxia;in vivo;Induced Neurons;insight;Ischemia;Ischemic Stroke;Light;light effects;Link;Literature;Location;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Mitochondrial Electron Transport Complex I;Mitochondrial Matrix;mitochondrial therapeutics;model organism;Modeling;Molecular;NADH dehydrogenase (ubiquinone);Nature;Nerve Degeneration;neural circuit;neuronal circuitry;Neurons;Neuropathy;novel;optogenetics;Organism;Outcome;Output;oxidation;Oxidation-Reduction;oxidative damage;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;Physiology;Play;pleiotropism;Predisposition;Process;Production;programs;Proliferating;protein activation;Proteins;Protons;Publishing;Reactive Oxygen Species;Recovery;Reperfusion Injury;Research Personnel;Resistance;Respiration;respiratory;Respiratory Chain;response;Role;Second Messenger Systems;Seminal;sensor;Severities;Signal Pathway;Signal Transduction;Site;spatiotemporal;Stress;Stroke;stroke model;System;Techniques;Testing;Tissues;Titrations;tool;Translating;Translations;Work

PROJECT_TITLE: Mitochondrial ROS Microdomains and Neuronal Ischemia

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Genomic rearrangements involving the ETS transcription factor family genes are causally associated with the development of prostate cancer. The overall goal of this proposal is to apply innovative genomics approaches to define the origins of recurrent genomic rearrangements in prostate cancer. Defining the mechanisms associated with the formation of recurrent genomic rearrangements will contribute towards our understanding of prostate cancer etiology and will impact several aspects of clinical disease management ranging from prevention, early diagnosis and therapeutic targeting.

PI_NAMEs: MANI, RAM SHANKAR (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Androgen Receptor;Androgens;Architecture;Award;Basal Cell;Basic Science;Benign;Bromodomain;Cancer Etiology;cancer genome;cancer type;causal variant;cell type;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Clinical;Clinical Data;Clinical Trials;Data;Data Set;Development;Disease Management;DNA;DNA Double Strand Break;DNA Polymerase II;DNA Repair;DNA Sequence Rearrangement;Early Diagnosis;Elements;Enzymes;Epithelium;ERG gene;ETV1 gene;ETV4 gene;Event;fusion gene;Future;Gene Family;Gene Fusion;Gene Rearrangement;Genes;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomic Segment;Genomics;Germ Lines;Goals;Human;Impairment;In Vitro;in vivo;Inflammation;innovation;insight;Ionizing radiation;Journals;Knowledge;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;Methodology;Methods;Modeling;novel;Outcome;overexpression;Oxidative Stress;Oxidative Stress Induction;Paper;Pathway interactions;Population;Prevention;Process;Prostate;prostate cancer model;Prostate Cancer therapy;Proteins;Proto-Oncogenes;Publications;Publishing;Radical Prostatectomy;Reactive Oxygen Species;Recurrence;Regulation;Reporting;Research Personnel;Risk;RNA;Role;Science;Signal Induction;Signal Transduction;Site;Source;Specimen;Stress;Techniques;Testing;Therapeutic;therapeutic target;TMPRSS2 gene;Topoisomerase II;transcription factor;Transcriptional Regulation;Transplantation;tyrosyl-DNA phosphodiesterase;Variant;Work

PROJECT_TITLE: 3D genome architecture and the origins of recurrent genomic rearrangements in prostate cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project narrative: There has been a significant increase in incidentally discovered localized renal tumors, and it remains a challenge to reliably and noninvasively differentiate benign tumors from renal cancers or differentiate low grade from high grade renal cancers. In this study, we will apply a powerful imaging technology, hyperpolarized 13C metabolic MRI, to renal tumors for the first time to address an unmet need for noninvasive predictors of tumor aggressiveness. Successful completion of this work will aid in future management of patients with renal tumors by reducing the current overdiagnosis and treatment of indolent tumors while enabling early detection of aggressive renal cancers that require timely surgery.

PI_NAMEs: LARSON, PEDER ERIC ZUFALL;WANG, ZHEN JANE (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Address;Benign;Biological Markers;Biopsy;Calibration;Cardiovascular Diseases;Cessation of life;Chronic Kidney Failure;Clinical;clinical application;Clinical Protocols;Clinical Research;cohort;cost;Data;Data Set;Detection;Diagnosis;Diagnostic;Disease;Early Diagnosis;Evaluation;Excision;Future;Glycolysis;Goals;Histology;Human;Image;imaging approach;imaging biomarker;Imaging Techniques;Imaging technology;improved;Incidence;Incidental Discoveries;Indolent;innovation;Investigation;Kidney;Kidney Neoplasms;kinetic model;Lactate Dehydrogenase;Link;Local Therapy;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant - descriptor;Malignant neoplasm of kidney;Malignant Neoplasms;Maps;Measures;Mediating;Metabolic;metabolic imaging;Metabolism;metabolomics;Methods;Modeling;molecular imaging;Motivation;Neoplasm Metastasis;Noise;novel;Operative Surgical Procedures;overtreatment;Pathology;Pathway interactions;Patient Selection;Patients;Performance;pre-clinical;Production;Prognosis;Pyruvate;Pyruvate Metabolism Pathway;radiomics;Reference Standards;Renal Carcinoma;Renal Cell Carcinoma;Reproducibility;response;RF coil;Risk;risk stratification;Running;Safety;Scanning;Signal Transduction;standard of care;surgical risk;temporal measurement;Testing;Time;Translating;tumor;tumor metabolism;Unnecessary Surgery;Validation;Visualization;Work

PROJECT_TITLE: Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: The Indiana University School of Medicine is home to the Indiana Alzheimer’s Disease Research Center, the National Cell Repository for Alzheimer’s Disease, the Regenstrief Institute, the Center for Aging Research, the MODEL-AD Center, as well as administering the LEADS trial, which collectively receive >$100M in NIA funding. We propose to restructure the graduate program in Medical Neurosciences and initiate a postdoctoral training program to provide a skilled scientific workforce to these research centers. Importantly, we propose to employ the Medical Neurosciences Training Program to functionally integrate the scientific activities of the NIA supported investigators across IUSM and with Eli Lilly.

PI_NAMEs: LANDRETH, GARY E. (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: academic program;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Model;Award;Basic Science;brain health;Caliber;cell repository;Clinical;Clinical Trials;cognitive function;Collaborations;Communities;design;Development;Doctor of Medicine;doctoral student;Early Onset Alzheimer Disease;Education;Educational Curriculum;Educational Status;Elements;Employee;experience;Faculty;Funding;Goals;Graduate Education;graduate student;Home;Human Resources;Indiana;Individual;Institution;Instruction;Investments;Laboratories;Leadership;Medical;medical schools;Neurodegenerative Disorders;Neurosciences;Neurosciences Research;post-doctoral training;Postdoctoral Fellow;Principal Investigator;programs;recruit;Research;Research Activity;Research Institute;Research Personnel;Resources;Series;skills;success;Talents;Training;Training Activity;Training Programs;Training Support;Translational Research;undergraduate research experience;Universities;Work

PROJECT_TITLE: Academic Leadership Award at the Indiana University School of Medicine

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Long-term cancer remission requires generation of tumor-specific immune memory. Memory T cells that reside in primary sites of tumor growth and in sites prone to metastasis such as the lymph node are particularly critical. This application examines requirements for maintaining these tissue-resident memory T cells and their importance in durable anti-tumor responses.

PI_NAMEs: HUANG, YINA HSING (contact);TURK, MARY JO

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Affect;anti-melanoma immunity;Antigen-Presenting Cells;Antigens;Antitumor Response;Autoantigens;Autoimmunity;Blood;Cancer Remission;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cell Physiology;Cells;chemokine;CXCR6 gene;Data;Dendritic Cells;Dependence;Dermis;Disease-Free Survival;draining lymph node;Excision;Future;Generations;Genetic Transcription;Growth;Hair follicle structure;Image;Immune checkpoint inhibitor;Immune response;Immunity;Immunologic Memory;Immunotherapy;Infection;Inflammation;Invaded;ITGAX gene;Knock-out;Laboratories;Location;Longevity;Lymph Node Subcapsular Sinus;Lymph Node Tissue;lymph nodes;Lymphoid;Maintenance;Malignant Neoplasms;Melanoma;Melanoma patient;Melanoma Tumor;Memory;memory recall;memory retention;Modeling;Molecular;mouse model;Mus;Myeloid Cells;Neoplasm Metastasis;novel;Operative Surgical Procedures;Population;Positioning Attribute;receptor;Recurrent tumor;Reporting;residence;response;Role;Sentinel;Signal Transduction;Site;Skin;Skin Tissue;Survivors;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Transcript;tumor;Tumor Cell Invasion;tumor growth;Tumor Immunity;Tumor Tissue;Virus Diseases;Vitiligo;Work

PROJECT_TITLE: Sustaining Tissue Resident Memory T cells

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: NARRATIVE We propose to develop the first scalable, multi-frequency, phased-array, real-time, quantitative deep tissue optical imager based upon frequency-domain diffuse optical spectroscopy. This breakthrough in functional imaging is enabled by novel advances in hardware and software, ushering in a next generation of diffuse optical spectroscopy and tomography with unprecedented resolution, localization, depth sensitivity, and speed. This work will help meet the rapidly growing demand for more powerful technologies in personalized medicine and wellness. 1

PI_NAMEs: OSULLIVAN, THOMAS D (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Adjuvant Chemotherapy;Adopted;Algorithms;Area;Brain imaging;breast cancer diagnosis;Breast Cancer therapy;breast imaging;Breast Oncology;Clinical;clinical application;Clinical Data;Clinical Research;Complex;Computer software;computerized data processing;Critical Care;Data;data acquisition;data standards;density;design;detector;Development;Devices;Diagnosis;Diagnostic;Diffuse;diffuse optical spectroscopy and imaging;Electronics;Evaluation;Exercise Physiology;Fiber;flexibility;Frequencies;Functional Imaging;functional near infrared spectroscopy;Goals;Health;high resolution imaging;Human;human disease;Image;image reconstruction;imager;imaging modality;imaging platform;Imaging technology;improved;individual response;innovation;integrated circuit;large datasets;Lasers;Location;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Medical Imaging;Methods;Modality;Multi-site clinical study;Near-infrared optical imaging;Neoadjuvant Therapy;neuroimaging;Neurology;next generation;Noise;novel;optical imager;optical imaging;Optics;Performance;personalized care;personalized medicine;Phase;photoacoustic imaging;photomultiplier;Physiology;prevent;Process;Property;reconstruction;Resolution;Sampling;Scalp structure;secondary analysis;Signal Transduction;Silicon;Source;Spectrum Analysis;Speed;Structure;System;Techniques;Technology;technology platform;technology validation;temporal measurement;Three-Dimensional Image;Time;tissue reconstruction;Tissue Sample;Tissues;tomography;tool;Translating;Translations;treatment response;tumor;validation studies;wearable device;Work

PROJECT_TITLE: Next generation deep tissue quantitative optical imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our new nanoparticle system enables systemic de- livery of nucleic acids, which have not translated to a standard-of-care due to the delivery challenge but would otherwise have great therapeutic potential for various diseases. Therefore, this research is consistent with the mission of the NIH, which pertains to developing resources that will assure the nation's capability to efficiently prevent and/or treat human diseases.

PI_NAMEs: KRON, STEPHEN J.;YEO, YOON  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Adopted;Albumins;Antibodies;Binding;Biodistribution;Biological;Blocking Antibodies;cancer therapy;capsule;CD47 gene;Cessation of life;Characteristics;Charge;chemotherapy;Chemotherapy and/or radiation;Circulation;Clinic;clinical translation;design;Development;Diagnosis;Disease;Drug Delivery Systems;Drug Kinetics;Encapsulated;Environment;Extravasation;Formulation;Future;Gene Delivery;Gene Targeting;Genes;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;human disease;Image;image guided;image-guided radiation;Imaging Device;Immune;immune checkpoint blockade;Immunosuppression;Immunotherapy;improved;In Vitro;innovation;intravenous injection;irradiation;Malignant Neoplasms;Mediating;Metastatic/Recurrent;Methods;Mission;Modeling;nanocapsule;nanomedicine;nanoparticle;Nature;neoplastic cell;novel;nucleic acid delivery;Nucleic Acids;Nucleosome Core Particle;Oral cavity;Oropharyngeal;Penetration;Permeability;Pharmacodynamics;Porosity;prevent;Production;programmed cell death ligand 1;Public Health;Radiation;Recovery;Regulatory Pathway;Research;Research Personnel;Resistance;Resources;response;RNA Interference;Safety;Signal Transduction;Silicon Dioxide;siRNA delivery;Small Interfering RNA;Solid Neoplasm;standard of care;success;Surface;Synthetic Genes;System;Systemic Therapy;targeted agent;targeted cancer therapy;targeted imaging;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic siRNA;Thick;Three-Dimensional Imaging;Time;Tissues;tomography;Toxic effect;Translations;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE: Mutations in the GBA gene are the biggest genetic risk factor for Lewy body dementia, a neurodegenerative disease that affects at least 1 in 100 people over 65, but it is not clear how those mutations harm brain cells. To find out the answer, we made a GBA mutant fruit fly; we learned that the mutant has an overactive immune system, and that blocking an immune pathway in the brain reduced the buildup of abnormal tangled proteins. We now plan to study how GBA mutations activate the immune system and how the overactive immune system kills brain cells, because the answers may help us prevent many diseases in which brain cells die.

PI_NAMEs: PALLANCK, LEO J (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: activating transcription factor;Address;Affect;Age-associated memory impairment;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;American;ATF2 gene;Biochemical;Biogenesis;Biological Assay;Biology;Blood;Brain;brain cell;Central Nervous System;Defect;Development;Dimerization;Disease;Drosophila genus;Enzymes;experimental study;extracellular vesicles;fly;follow-up;Genes;Genetic;genetic risk factor;Genetic Transcription;glucosylceramidase;Glucosylceramides;Glycosphingolipids;Hemolymph;Immune;immune activation;Immune response;Immune system;Impairment;innate immune mechanisms;innate immune pathways;Innate Immune System;Insecta;Intervention;knock-down;Lead;Learning;Lewy Body Dementia;Ligands;Link;Mediating;Medical;Membrane;Mitogens;Modeling;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;novel;Orthologous Gene;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Persons;pharmacologic;Phenotype;Play;prevent;Process;Production;Property;protein aggregation;Protein Kinase;Proteins;Proteomics;Receptor Activation;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;response;Risk;Risk Factors;RNA interference screen;Role;Signal Pathway;Signal Transduction;Source;Sphingolipids;Testing;Transcript;transcriptome sequencing;Tyrosine Phosphorylation;Ubiquitin;upstream kinase;vesicular release;Work

PROJECT_TITLE: Mechanism of innate immune activation in a Drosophila model of Alzheimer's disease related dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Ohio State University Comprehensive Cancer Center (OSUCCC) is a matrix cancer center that integrates and leverages all of the resources of the University to achieve its broad vision of creating a cancer free world. The OSUCCC addresses the public health needs of the catchment area (the state of Ohio) through research, education and community outreach and engagement as research conducted within the five OSUCCC Programs focuses on high priority cancers for the OSUCCC including lung, breast, colorectal, prostate, endometrial, cervical cancer, thyroid, and leukemia, as well as tobacco use, obesity and HPV vaccination. Screening and outreach activities are provided to the populations across the lifespan that we serve, especially those with higher burden of being diagnosd with cancer, such as racial/ethnic minorities and other underserved populations (e.g., rural, LGBTQ+, Appalachian) through targeted, culturally appropriate education activities, free cancer screenings, patient navigation, community networking, environmental scans, and addressing policy issues.

PI_NAMEs: POLLOCK, RAPHAEL E. (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;anti-cancer research;Appalachian Region;Attention;Basic Science;Breast;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer prevention;cancer research center director;Cancer Survivorship;Catchment Area;Chemoprevention;clinical development;Clinical Research;Clinical Trials;Colorectal;Community Networks;Community Outreach;Comprehensive Cancer Center;Descriptor;Doctor of Philosophy;Education and Outreach;Educational Activities;Endometrial;Engineering;ethnic minority;Etiology;Faculty;FDA approved;Fostering;Funding;Growth;Hematopoietic Neoplasms;Human Papilloma Virus Vaccination;Immunooncology;innovation;Institution;Intervention;Investments;Journals;Leadership;Lesbian Gay Bisexual Transgender Queer;leukemia;life span;Lung;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;member;Mission;Molecular Biology;Molecular Carcinogenesis;Morbidity - disease rate;mortality;Multicultural Education;next generation;Obesity;Ohio;outreach;patient navigation;Patients;Peer Review;Pharmaceutical Preparations;Policies;Population;Population Research;Population Sciences;preclinical development;Prevention;programs;Prostate;Public Health;Publications;Publishing;racial minority;recruit;Research;Resource Sharing;Resources;Rural;Scanning;Scientist;screening;Screening for cancer;Strategic Planning;survivorship;Therapeutic Trials;Thyroid Gland;Tobacco use;Training;Translating;translational genomics;Translational Research;translational therapeutics;Underserved Population;Universities;University resources;Vision

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE  To generate the scientific discoveries and medical interventions that meet the needs of our citizens, we must harness the inherit research talent present in the United States of America. However, disparities in the population of biomedical Ph.D. scientists indicate that innovative graduate training programs are needed to better recruit and retain researchers from a variety of backgrounds. The UCSC IMSD graduate training program creates an inclusive and interdisciplinary community that develops research and leadership skills across a diverse graduate student population to prepare the next generation of research scientists in the biomedical sciences.

PI_NAMEs: JURICA, MELISSA S (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: California;Universities

PROJECT_TITLE: IMSD at the University of California Santa Cruz

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GOSKY, DAVID M (contact)

PROJECT_TERMS: Acceleration;Achievement;Administrator;Advisory Committees;animal imaging;anti-cancer research;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;Cancer Hospital;cancer prevention;cancer research center director;career development;Catchment Area;Clinical;Clinical Data;Clinical Protocols;Clinical Research;clinical translation;Clinical Trials;Collaborations;college;Colon Carcinoma;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;data management;Dedications;Development;Doctor of Philosophy;Education;Endometrial Carcinoma;Engineering;Ensure;Evaluation;Evolution;experience;Faculty;Faculty Recruitment;Floor;Fostering;Foundations;Funding;Future;Genes;Goals;Grant;Growth;Health;Height;Immunooncology;improved;Infrastructure;innovation;Interdisciplinary Study;International;Intervention;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;meetings;member;Mentors;Minority;Ohio;Oncology;Outcome;Paper;patient navigator;patient outreach;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;recruit;Reporting;Research;research facility;Research Institute;Research Personnel;Resource Sharing;Resources;Role;Schedule;Science;Secure;Services;social media;Strategic Planning;Students;success;symposium;synergism;System;Systems Integration;Tobacco;Training;Training Activity;Training and Education;translational genomics;Translational Research;Translations;Universities;Validation;Vision;web site;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunization;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative This project develops new strategies to improve the safety and efficacy of antibody-drug conjugate (ADC) therapy of acute myeloid leukemia (AML). AML is the most common form of leukemia; safe and effective therapies are urgently needed. If successful, this project will lead to validation of new therapeutic strategies and to the development of new drugs, potentially leading to life-saving benefits for a large population of patients.

PI_NAMEs: BALTHASAR, JOSEPH P (contact);SHAH, DHAVAL K

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affinity;Animal Model;Antibodies;Antibody-drug conjugates;Antigens;arm;Binding;Biological Assay;Bispecific Antibodies;Blast Cell;cancer cell;Cell Culture Techniques;Cell membrane;Cells;Characteristics;chemical conjugate;cytotoxic;cytotoxicity;design;Development;Dose;Drug Delivery Systems;Drug Kinetics;Drug toxicity;effective therapy;Engineering;Enhancers;Evaluation;experimental study;Extracellular Domain;Future;Human;human model;IL3RA gene;Immunoglobulin Fragments;improved;in vivo;in vivo evaluation;Investigational Drugs;leukemia;leukemic stem cell;Life;mathematical model;Membrane Proteins;Modality;Modeling;models and simulation;Monoclonal Antibodies;mouse model;Mus;nanobodies;New Agents;novel therapeutic intervention;novel therapeutics;off-target site;overexpression;patient population;Patients;Pattern;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacology and Toxicology;Plasma;pre-clinical;predictive modeling;prevent;Process;research clinical testing;Safety;safety testing;Site;Specificity;Surface Antigens;targeted agent;Testing;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;treatment strategy;tumor;Validation;vector;Work

PROJECT_TITLE: Pharmacokinetic / Pharmacodynamic Optimization of ADC Therapy for Acute Myeloid Leukemia