ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Due to the increased lifespan of our population, problems linked to age-associated cognitive decline and neurodegeneration are becoming more important. It is recognized that many different molecular factors are at play in Alzheimer’s disease (AD) pathogenesis and dysregulations of these diverse molecules are not uniform throughout AD progress due to heterogeneity of the brain. However, most of the current studies involve homogenized tissues or biofluids without spatial information. To address this critical knowledge gap, this grant application seeks to create a region-specific biomolecule atlas of the AD brain of animal models and postmortem AD brain tissue using a suite of mass spectrometry imaging technologies in conjunction with machine-learning approaches. The proposed work offers a multifaceted approach and has strong translational potential that is highly relevant to human aging and human diseases.

PI_NAMEs: LI, LINGJUN  (contact);PUGLIELLI, LUIGI

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age-associated memory impairment;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Animal Model;Anterior;APP-PS1;Applications Grants;Area;Atlases;Autopsy;Biochemical Process;Biological;Biological Models;biological systems;biomarker discovery;Body Fluids;Brain;brain metabolism;brain tissue;Ceramides;Chemistry;Classification;cohort;Communities;Coupled;Data;Defect;Development;diagnostic biomarker;Dimensions;Disease;Disease Progression;Endoglycosidase F;Event;extend lifespan;Functional disorder;Funding;Glucose;Glycoproteins;Glycoside Hydrolases;glycosylation;Heterogeneity;Human;human disease;humanized mouse;imaging approach;imaging platform;Imaging technology;Impaired cognition;Informatics;innovation;Isomerism;Knock-in;Knock-in Mouse;Knowledge;Late Onset Alzheimer Disease;Link;lipid metabolism;lipidome;Lipids;Liquid Chromatography;Locales;Machine Learning;machine learning algorithm;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Membrane Glycoproteins;Membrane Lipids;Metabolic;Metabolism;metabolomics;Modeling;Molecular;Molecular Target;mouse model;Mus;Nerve Degeneration;neuropathology;novel;Occipital lobe;Organism;Paint;Parietal;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pattern;Peracetic Acid;Physiological;pi bond;Play;Point Mutation;Polysaccharides;Population;Proteomics;proteostasis;Reporting;Research;response;Role;sialylation;Spatial Distribution;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingolipids;Symptoms;Technology;tissue biomarkers;Tissue Sample;Tissues;trafficking;translational potential;Unsaturated Fats;Validation;Wisconsin;Work

PROJECT_TITLE: Creating a region- specific biomolecular atlas of the brain of Alzheimer’s disease


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MEMPHIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Epilepsy is a devastating disorder that affects millions of people in the US alone. In this project we propose to study the cause of a certain type of seizure disorder mediated by high levels of a protein called UBE3A in the brain. We will use genetically modified fruit flies and mice to manipulate different types of cells in the brain that express this protein that is responsible for the seizures and then find the proteins involved in this type of epilepsy.

PI_NAMEs: REITER, LAWRENCE T (contact);ZAKHARENKO, STANISLAV S

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 15q;Affect;Alleles;anti-epileptic agents;Anticonvulsants;Autopsy;Behavior;Behavioral;Brain;Buffers;Calcium;cell type;cellular pathology;Cephalic;chromosome 15q duplication syndrome;Country;Defect;design;Development;dietary;Disease;Drosophila genus;Drosophila melanogaster;epidemiology study;Epilepsy;Etiology;experimental study;extracellular;fly;GABA Receptor;Gene Modified;Goals;Homeostasis;Homologous Gene;Homologous Protein;Impairment;Individual;insight;Intervention;Knowledge;Laboratories;Learning;Mammals;Mediating;Modeling;Molecular;molecular pathology;mouse model;Mus;neurogenetics;Neuroglia;Neurons;neurotransmission;new therapeutic target;overexpression;Paracrine Communication;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Potassium;Predisposition;Process;Proteins;Proteomics;Receptor Gene;Reproducibility;Research;Role;Seizures;Signal Transduction;small molecule therapeutics;Synapses;Syndrome;Temperature;Therapeutic;Time;UBE3A gene;ubiquitin-protein ligase;Work

PROJECT_TITLE: The role of UBE3A in gliopathic seizures

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: POMONA

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE POLY U POMONA

ORG_STATE: CA

PHR: By increasing the number of individuals who obtain PhDs in biomedical research, from groups that are under-represented in this field, the diverse communities in which these individuals have grown up, will have new role models for their following generations. As a PhD scientist, these individuals will have the credibility and background to be able to communicate effectively to these communities about how important biomedical research is to making discoveries that will enhance their own health, reducing illnesses and lengthening lifespan, as well as contributing to the overall health of our society.

PI_NAMEs: BUCKLEY-NIEVES, NANCY ELIZABETH (contact);WILSON, EMMA H

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Integration of Research, Mentoring and Professional Skill Building for Master's Students to Bridge to a PhD Program in Biomedical Science

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Age, frequent exposure to loud noise, genetic disorders and more contribute to hearing loss, which affects half a billion people worldwide. In this proposal, we advocate for the use of the pig as a translational animal model to study non-invasive local drug delivery to the inner ear, given that the pig’s size, anatomy, and genetics is closer to humans than rodents. Using the pig as a large animal model will open translational opportunities to test new safe delivery approaches for hearing restoration.

PI_NAMEs: GREENBAUM, ALON  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: 3-Dimensional;Address;Advocate;Affect;Age;Anatomy;Animal Model;Apical;base;Basilar Membrane;Biodistribution;Biological;Blood;Cardiovascular system;cell injury;Chemicals;Cochlea;Dementia;Dexamethasone;Diffuse;Diffusion;Drug Delivery Systems;drug distribution;Drug Modelings;Drug Transport;Ear;effective therapy;Encapsulated;Etiology;Evaluation;Exposure to;External auditory canal;Family suidae;Future;Genetic;Genetic Diseases;Goals;Hair Cells;hearing impairment;hearing restoration;Hour;Human;Image;image guided;Impaired cognition;in vivo;in vivo imaging;in vivo Model;Injections;insight;Intelligence;Label;Labyrinth;Length;Liquid substance;Livestock;local drug delivery;Loudness;Measures;Medical;Medicine;Membrane;membrane model;Mental Depression;meter;Methodology;Methods;Microscopy;middle ear;minimally invasive;Modeling;Molecular;Mus;Neurons;neurotrophic factor;Newborn Infant;Noise;noise exposure;novel;novel therapeutics;Nutritional Study;Operative Surgical Procedures;Organ Transplantation;ototoxicity;Outcome;Pathway interactions;Penetration;Perforation;Perilymph;Permeability;Persons;Pharmaceutical Preparations;Physicians;porcine model;pre-clinical;Public Health;Research;Resolution;Rodent;Rodent Model;round window;Sampling;Scientist;simulation software;small molecule;Social isolation;Study models;success;Surgical incisions;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Thick;Thinness;Tissues;translational potential;Tympanic membrane;Variant;Viral Vector;Virus;Work;wound healing

PROJECT_TITLE: Establishing the pig as a large animal model for studying drug delivery to the inner ear


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Millions of children are infected with the malaria parasite, and many die from cerebral malaria, partly because they lack antibodies to malaria. We will study antibodies to proteins from cells infected with malaria and on the parasites themselves, comparing findings in children with malaria infections that span the spectrum from asymptomatic to life-threatening cerebral malaria. We will undertake detailed antibody profiling and use advanced statistics to identify antibodies that protect against malaria, in the expectation that this might lead to new approaches to malaria prevention and treatment.

PI_NAMEs: ROGERSON, STEPHEN ;SEYDEL, KARL BOYNTON (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Acute;Adhesions;African;Antibodies;Antibody Avidity;Antibody Response;antibody test;Antibody-mediated protection;Antigen Targeting;Antigens;Avidity;Behavioral;Binding;Biological Assay;Biological Markers;biomarker identification;biophysical properties;Biophysics;Blood;Brain Edema;Cells;Cerebral Malaria;Cerebrovascular system;Cessation of life;Characteristics;Child;Clinical;clinical diagnosis;clinical phenotype;Cognitive;cohort;Collection;Communities;Complement;Complex;Computational Biology;Convalescence;convalescent plasma;Data;Data Analyses;Development;Dimensions;Enrollment;Erythrocyte Membrane;Erythrocytes;Evolution;expectation;Fc Receptor;Genetic Transcription;glycosylation;Goals;high risk;Immune Targeting;Immunity;Immunology;Infection;Infection Control;international center;Lead;Life;Longitudinal cohort;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Malaria;malaria infection;Malaria prevention;Malawi;Measures;Mediating;Membrane Proteins;monocyte;MRI Scans;Natural Killer Cells;neurovascular;neutrophil;novel strategies;Outcome;Parasitemia;Parasites;Pathogenicity;Phagocytosis;Phenotype;placental malaria;Plasmodium falciparum;Plasmodium falciparum erythrocyte membrane protein 1;Predisposition;Pregnancy;prevent;Property;Protein Fragment;Proteins;recruit;Research;Respiratory Burst;response;Retina;Retinal Diseases;Serology;Site;skills;statistics;Surface;Survivors;Syndrome;System;Technology;Therapeutic;therapeutic development;tool;vaccine development;Vaccines;Visualization;Whole Blood;Woman;Work

PROJECT_TITLE: Identifying functional antibody responses that protect against malaria in children

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Intestinal bacterial pathogens are a major cause of morbidity and mortality globally and a leading cause of death among children. The goals of this proposal are to understand how specific metabolites from bacteria regulate host epithelial cells to protect against intestinal bacterial infection. The outcomes of these studies will benefit human health because they will inform the design of new approaches for improving intestinal immunity to fight infection.

PI_NAMEs: ALENGHAT, THERESA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: aldehyde dehydrogenases;Anti-Bacterial Agents;Bacteria;Bacterial Infections;beneficial microorganism;Calibration;Cause of Death;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Child;Citrobacter;Citrobacter rodentium;combat;commensal bacteria;Complex;Data;design;Development;Diet;dietary;Dietary Component;dietary requirement;Enteral;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Enzymes;Epigenetic Process;epigenome;Epithelial Cells;epithelial repair;Epithelium;Escherichia coli Infections;experimental study;Exposure to;fighting;Gene Modified;Genetic Transcription;Gnotobiotic;Goals;HDAC3 gene;Health;Histones;Homeostasis;Host Defense;Human;human model;Immune;Immune response;Immunity;improved;in vitro Assay;Infection;inorganic phosphate;Inositol;insight;intestinal barrier;intestinal epithelium;Intestines;Knowledge;Link;Mammalian Cell;Mediating;Metabolism;Microbe;microbial;microbiota;microbiota metabolites;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;NOS2A gene;novel;novel strategies;Organoids;Outcome Study;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;pharmacologic;Play;Predisposition;prevent;Public Health;Publications;receptor expression;Regulation;response;Retinoic Acid Receptor;Role;Signal Transduction;Site;Testing;therapeutic evaluation;Tissues;tool;Transgenic Animals;Transgenic Mice;Tretinoin;Vitamin A;Volatile Fatty Acids;Work

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Agent Orange & Dioxin;Biotechnology;Digestive Diseases;Endocrine Disruptors;Genetics;Human Genome;Liver Disease

PHR: PROJECT NARRATIVE Even with reduced body burdens, human exposure to the highly toxic compound 2,3,7,8-Tetrachlorodibenzo-p- dioxin (TCDD) and other dioxin-like chemicals remain a public health concern, especially for vulnerable populations like infants. While most biological effects of TCDD are known to be mediated by the aryl hydrocarbon receptor (AHR), the identity of specific genes connecting AHR activation to toxic outcomes of TCDD exposure remains unknown. Here we propose to combine functional genomic experiments, computational modeling, and targeted epigenome editing to map AHR-mediated gene regulatory networks and predict TCDD-induced changes in gene expression in mouse vs. human liver and B cells.

PI_NAMEs: BHATTACHARYA, SUDIN  (contact);CUDDAPAH, SURESH

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adverse effects;adverse outcome;Aryl Hydrocarbon Receptor;ATAC-seq;B-Lymphocytes;Binding;Binding Sites;Biological;Biological Assay;Body Burden;Breastfed infant;Cells;Chemical Exposure;Chemicals;ChIP-seq;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;computational basis;Computer Models;Congenital Abnormality;CRISPR interference;Data;Data Set;Development;differential expression;Dioxins;DNA;DNA Sequence;Environmental Pollutants;Epigenetic Process;epigenome editing;epigenomics;experimental study;exposed human population;Exposure to;Fishes;Food;Food Chain;functional genomics;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;health assessment;Hepatocyte;Hepatotoxicity;histone modification;Human;Human Cell Line;Immunosuppression;improved;in utero;Infant;Ingestion;innovation;Knowledge;Ligands;Liver;Maps;Mediating;Medical center;Michigan;Modeling;multidisciplinary;Mus;novel;Nucleic Acid Regulatory Sequences;Outcome;Poison;Population;predictive modeling;Promoter Regions;Public Health;Receptor Activation;receptor binding;Receptor Signaling;Regulatory Pathway;response;Response Elements;Risk;Risk Assessment;Risk Estimate;Rodent;Role;sensor;species difference;Statistical Models;Testing;Tetrachlorodibenzodioxin;Tissue Model;Tissues;Toxic effect;toxicant;Training;transcription factor;transcription regulatory network;transcriptome sequencing;United States National Institutes of Health;Universities;virtual;Vulnerable Populations;Wasting Syndrome;Work;Xenobiotics

PROJECT_TITLE: Integrative transcriptional and epigenomic modeling of xenobiotic-activated gene regulatory networks

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Alzheimer’s disease (AD) is not exactly the same in women and in men, so that in order to design more effective surveillance, screening, preventive, and risk assessment programs, we need new methods that are sensitive and accurate enough to detect differences in how genetic variants are linked to AD risk in women and men. For this we propose a variety of new statistical and machine learning tools that will interpret the variants observed in human genomes from patients in light of the entire history of past evolutionary mutations and adaptations. The best candidate genes we find will then be tested experimentally in AD animal-models (mouse and Drosophila) to yield highly validated sex-specific predictors of AD status that could enable precise risk stratification, provide sex-specific biomarkers, highlight sex-differential disease mechanisms and reveal potential therapeutic targets.

PI_NAMEs: AL-RAMAHI, ISMAEL ;LICHTARGE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Affect;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acids;Amyloid beta-Protein;anillin;Animal Disease Models;Apolipoprotein E;Autopsy;Benchmarking;Biological Markers;Biological Models;Brain;brain cell;brain tissue;Candidate Disease Gene;candidate validation;Cerebrospinal Fluid;Code;cohort;comorbidity;Data;Dementia;design;Disease;Disease stratification;Drosophila genus;Evolution;experimental study;Female;Freezing;Gender;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;genomic variation;Heritability;Human;Human Genome;improved;in vivo;Individual;insight;interest;laboratory experiment;Light;Link;loss of function;Machine Learning;machine learning algorithm;male;men;Methods;Modeling;Molecular;mouse model;Mus;Mutation;Neighborhoods;neuroinflammation;neuropathology;neurotoxicity;novel;novel strategies;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Phylogenetic Analysis;Population;Population Attributable Risks;Prevalence;Prevention;Preventive;programs;protective effect;Proteins;Recording of previous events;Rest;Risk;Risk Assessment;risk stratification;risk variant;robot assistance;Sample Size;Sampling;screening;sex;Sex Differences;specific biomarkers;statistical and machine learning;statistical learning;stem;Stratification;System;tau Proteins;Testing;Therapeutic;therapeutic target;Time;tool;translational study;Validation;Variant;Woman;Work

PROJECT_TITLE: Decoding the impact of sex differences on Alzheimer's disease risk


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE MicroRNAs are small non-coding RNAs that provide an important layer of gene regulation by negatively controlling the levels of a large fraction of protein coding genes. The research proposed in this grant application has three major goals. First, we want to determine the role of miRNA function during mammalian development, in tissue homeostasis, and during tissue regeneration. Second, we want to test whether that acute inhibition of miRNA function can serve as a novel and effective anticancer strategy. Finally, we want to understand what targets and pathways miRNAs control under these conditions.

PI_NAMEs: VENTURA, ANDREA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acute;Address;Adult;Affect;Aging;Alleles;anti-cancer;Applications Grants;Binding;Biogenesis;Biological Process;Cancer cell line;cell type;Cells;Chronic;Code;Complex;Cues;Development;Doxycycline;Ensure;experimental study;gain of function;Gene Expression;Gene Expression Regulation;Gene Fusion;gene repression;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Homeostasis;human cancer mouse model;In Vitro;in vivo;Infection;Inflammation;Injury;innovation;insight;intestinal epithelium;Liver;loss of function;Maintenance;Malignant Neoplasms;Mammals;Maps;Mediating;member;Messenger RNA;MicroRNAs;Mouse Strains;Mus;Natural regeneration;Normal tissue morphology;novel;novel strategies;Nucleotides;Partner in relationship;Pathway interactions;Phenotype;Population;posttranscriptional;prevent;Process;protein degradation;Protein Family;Proteins;recruit;Repression;Research;Resolution;Ribonucleoproteins;Role;Series;Site;small molecule inhibitor;stem cell population;Testing;Time;tissue regeneration;Tissues;Transgenic Mice;Transgenic Organisms;tumor;tumor initiation;tumor progression;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Investigating microRNA Function in Homeostasis, Regeneration and Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Relevance to Public Health Purinergic signaling (i.e., response to extracellular nucleotides) is involved in a wide variety of disease states and is the target of valuable therapeutic agents. While all organisms respond to extracellular ATP, many lack the canonical receptors found in animals; for example, plants possess unique, multifunctional plant purinoreceptors, P2K1 and P2K2. Through comparison, the research described will identify conserved, common components of purinergic signaling pathways, which may be additional targets for therapy.

PI_NAMEs: STACEY, GARY  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adenylate Cyclase;Affect;Animals;ATP Receptors;BHLH Protein;Binding;Biochemical Reaction;Biochemistry;biological adaptation to stress;Biology;Calcium;Calcium Channel;Cell Communication;Cell membrane;Cell surface;Cells;comparative;Coupled;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;Cytoplasm;Data;Development;Disease;Drug Industry;Dwarfism;Eukaryota;Evolution;extracellular;Family;Gene Expression;Growth;Growth and Development function;GTP-Binding Proteins;Human body;Laboratories;Lectin Receptors;Mammalian Cell;Mammals;Mediating;mutant;Mutation;novel;Nucleotides;Organism;P2X-receptor;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Physiological Processes;plant growth/development;Plants;Process;Protein Kinase;Proteins;Public Health;Purinoceptor;receptor;receptor function;Regulation;Research;response;Role;Signal Pathway;Signal Transduction;Stress;targeted treatment;theories;Therapeutic;Therapeutic Agents;Tissues;virtual;Work;wound

PROJECT_TITLE: DORN1 defines a new family of receptor kinase purinoreceptors (P2K)

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Approximately 15% of two-year-olds are “late talkers,” who have smaller vocabularies and learn different types of words as compared to typically developing peers, contributing to an increased risk for a language disorder. Because of the important role that verbs play in language development, this project explores whether differences exist between late talkers and their peers in how they learn new verbs and whether language processing abilities might predict success in verb-learning tasks. Results from this study will provide insight into how late talker language development differs from typical development and will support further research into interventions for those at greatest risk for language disorder.

PI_NAMEs: HORVATH, SABRINA ELISE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 2 year old;6 year old;Age;Child;Data;design;Development;developmental disease;effective intervention;efficacious intervention;Etiology;Event;executive function;Failure;Future;Goals;Hearing;hearing impairment;Individual;individual response;insight;Intervention;Knowledge;Label;Language;Language Development;language disorder diagnosis;Language Disorders;language outcome;language processing;Learning;Learning Difficulty;lexical;life span;Linguistics;literacy;Literature;Longitudinal Studies;Longitudinal trends;Measures;novel;Outcome;outcome prediction;Pathologist;Pattern;peer;Performance;Play;Process;processing speed;Production;Regression Analysis;Research;Research Personnel;Risk;Role;Running;Sampling;Sign Language;skills;social skills;Speech;Structure;success;syntax;Testing;Toddler;Training;visual tracking;Vocabulary;word learning

PROJECT_TITLE: Identification of Differences in Verb Learning between Late Talkers and Typically Developing Children

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This decade has seen an explosive, devastating epidemic of opiate addiction in the U.S. Effective strategies to mitigate this epidemic must include both prevention (identifying addiction-prone individuals early and intervening effectively) and treatment, but few strategies for either currently exist. Using state of the art sequencing technology and robust rat models of heroin abuse and relapse, we ask how psychosocial stress early in life sex- dependently impacts gene expression networks to promote opioid use disorder (OUD)-like behavior, and potentially open new therapeutic avenues for OUD.

PI_NAMEs: BARAM, TALLIE Z. ;FOWLER, CHRISTIE D;MAHLER, STEPHEN VINCENT (contact);SWARUP, VIVEK

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Address;Adopted;Adult;Affect;Amygdaloid structure;ATAC-seq;Automobile Driving;Behavior;Behavioral;Blood;Brain region;Cell Physiology;cell type;Cells;cellular targeting;Chromatin;Chronic;critical period;Data;Development;Dimensions;Disease;disorder prevention;disorder risk;drug of abuse;drug seeking behavior;Drug usage;early life adversity;Environmental Risk Factor;Epidemic;epidemic response;Epigenetic Process;epigenome;epigenomics;Event;experience;Experimental Models;experimental study;Exposure to;Extinction;extracellular vesicles;Female;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Genetic;Genetic Transcription;Genome;Heroin;Heroin Abuse;heroin use;human data;Incidence;Individual;insight;Intervention;Life;male;Methods;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Motion;multiple omics;Nature;novel;novel marker;novel therapeutics;Nucleus Accumbens;Opiate Addiction;opioid abuse;opioid epidemic;opioid overdose;opioid use disorder;Play;Population;predictive marker;Prevention;Process;Psychosocial Stress;Rattus;Recording of previous events;Relapse;Resolution;Risk;Role;Sampling;Self Administration;sex;Sex Differences;Signal Transduction;single nucleus RNA-sequencing;Technology;Testing;transcriptome;transcriptome sequencing;transcriptomics;Vulnerable Populations

PROJECT_TITLE: Dynamic epigenomic landscape of opioid abuse following early-life adversity


ORG_CITY: LINCOLN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: This project is an in-depth study on how phosphorothioate-base antisense oligonucleotides (PS- ASO) bind and are internalized by the scavenger receptors (Stabilin-1 and Stabilin-2). We will determine how these receptors internalize their ligands (including size select hyaluronan and custom synthetic heparin), what determines their escape from endosomes and associated molecules involved with cargo escape, and their pharmacokinetics through an animal model. The understanding of how these molecules are metabolized in mammalian systems will greatly aid the design and therapeutic use of such drugs.

PI_NAMEs: HARRIS, EDWARD N (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Affect;Affinity;Animal Model;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;base;Binding;Biochemistry;Biodistribution;Biological;Biology;Bone Marrow;Cancer cell line;catalyst;cell type;Cells;Chemicals;Chemistry;Chondroitin Sulfates;Circulation;Clinic;Clinical;Code;combat;Complex;Custom;Data;Dedications;design;Discontinuous Capillary;Down-Regulation;Drug Kinetics;Endocytosis;endonuclease;Endosomes;Endothelial Cells;Excipients;Fluorescence Microscopy;Future;Gene Expression;Genes;Genetic;Genetic Diseases;Goals;Heparin;Heparitin Sulfate;Hepatocyte;Hyaluronan;in vivo;Injections;insight;Interferometry;intraperitoneal;Kidney;Kinetics;knock-down;Knock-out;Knockout Mice;Knowledge;Ligands;Liquid substance;Liver;lymph nodes;Lysosomes;Macrophage;Mediating;Messenger RNA;Metabolic;Metabolic Clearance Rate;Metabolic Diseases;Metabolism;Methods;Modification;mouse model;next generation;nuclease;oligonucleotide delivery;Oligonucleotides;Organ;Outcome;Oxygen;Paper;Pathway interactions;Pharmaceutical Preparations;phosphodiester;phosphorothioate;Physiological;Plasma;polyanion;Polymers;Positioning Attribute;Productivity;Property;Reaction;receptor;receptor internalization;receptor recycling;Recombinants;recruit;Research;Research Project Grants;Resistance;Ribonuclease H;Ribose;RNA;RNA Interference;scavenger receptor;Specificity;Spleen;stable cell line;Structure-Activity Relationship;subcutaneous;Sulfur;System;Therapeutic Uses;Tissues;trafficking;transcytosis;uptake;Urine;Vertebral column

PROJECT_TITLE: Metabolism of Antisense Oligonucleotides and other Polyanions in Liver

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE An important signaling cue in regeneration is the endogenous bioelectric signal, in which electric fields (EFs) initiate a cascade of complex signaling events between cells in order to promote tissue regeneration. The proposed project aims to utilize multidisciplinary approaches to develop new tools in order to investigate the role of small extracellular vesicles (EVs) in transmitting the bioelectric signals by means of gene regulatory molecules between cells, and hence, promote neuroregeneration.

PI_NAMEs: ESFANDIARI, LEYLA  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Axon;axon regeneration;bioelectricity;Biomimetics;Cell-Matrix Junction;Cells;Central Nervous System;Complex;Cues;electric field;Electric Stimulation;Embryonic Development;Event;Exocytosis;exosome;extracellular vesicles;Feedback;Fiber;functional restoration;Future;gene regulatory network;Genes;Goals;Growth;Homeostasis;interdisciplinary approach;Knowledge;mechanotransduction;nanoelectronics;nanofiber;Natural regeneration;nerve injury;Nerve Regeneration;Nervous System Disorder;Nervous System Trauma;Neurons;Pathway interactions;Peripheral Nervous System;Property;Proteins;repaired;Resolution;RNA;Role;Schwann Cells;Signal Transduction;Stimulus;Surface;Technology;Therapeutic;tissue regeneration;Tissues;tool;transmission process

PROJECT_TITLE: Nanoelectronics to study exosome circuitry and their role in neuroregeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Endometriosis affects both reproductive health and pregnancy outcomes. The proposed research to determine how cellular senescence affects the development and progression of ovarian endometriomas addresses an NICHD Gynecologic Health and Disease Branch strategic plan aspirational goal of accelerating efforts to treat endometriosis using non-hormonal therapeutics by targeting abnormal gynecologic cell types.

PI_NAMEs: HAWKINS, SHANNON MICHELLE (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Acceleration;Address;Adhesions;Adult;Affect;ARID1A gene;Assisted Reproductive Technology;Automobile Driving;beta-Galactosidase;Biological;Biological Markers;CDKN2A gene;Cell Aging;Cell Culture Techniques;Cell Cycle Arrest;Cell Differentiation process;Cell secretion;cell type;Cells;Cellular Morphology;cellular targeting;Clinical;Clinical Research;Data;Development;Developmental Process;Disease;Endometriomas;endometriosis;Enterobacteria phage P1 Cre recombinase;Excision;Exhibits;Fertility;Fertility Rates;Future;Ganciclovir;Genes;Genetic Engineering;Genetic Recombination;Goals;granulosa cell;Gynecologic;Harvest;Health;high risk;Histologic;hormone therapy;Human;improved;In Vitro;Individual;Inflammatory;KRAS oncogenesis;KRASG12D;Lesion;LoxP-flanked allele;Luciferases;Mediating;Modeling;Molecular;molecular marker;mouse model;Mus;Mutation;National Institute of Child Health and Human Development;neoplastic;novel;Operative Surgical Procedures;Ovarian;Ovarian Clear Cell Tumor;Ovary;Pancreas;Pathogenesis;Pelvic cavity structure;pharmacologic;Phenotype;Pregnancy Outcome;Process;Reproducibility;reproductive;Reproductive Health;Research;Research Personnel;Retrograde Menstruation;Role;senescence;senescence associated secretory phenotype;senescent cell;Senotherapeutic;Senotherapy;Signal Transduction;Strategic Planning;Surgical complication;surgical risk;Testing;theories;therapeutic target;Time;transcriptome;transcriptomics;transdifferentiation;Woman

PROJECT_TITLE: Targeting cellular senescence to inhibit the development and progression of ovarian endometriomas

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative These studies will define mechanisms and identify people who are at greatest risk for H. pylori-induced stomach cancer, which will substantially improve the diagnosis and therapy of this disease.

PI_NAMEs: PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: adaptive immune response;Adaptor Signaling Protein;Address;Attenuated;Bacteria;Biological Models;Biology;Biopsy;Cancer Etiology;cancer initiation;cancer risk;carcinogenicity;cell type;Cells;Cessation of life;Chronic;chronic pancreatitis;Clinical;Coculture Techniques;cohort;Colombia;cytokine;Data;Development;Diagnosis;Disease;disorder risk;DNA;DNA Viruses;Endoscopy;Epithelial Cells;Feedback;fitness;Funding;Gastric Adenocarcinoma;gastric organoids;Gastric Tissue;gastrointestinal;Genetic;Gerbils;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;high risk;Human;IL17 gene;Immune;Immune response;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Innate Immune Response;Innate Immune System;innovation;Intervention;Laboratories;Lesion;Link;Longitudinal cohort;Macrophage;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Microbe;microbial;Modeling;Molecular;Mucous Membrane;Mus;Myeloid Cells;Oncogenic;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptidoglycan;Persons;Positioning Attribute;premalignant;Proliferating;prospective;Proteins;receptor;Risk;Risk Factors;Sampling;self organization;sensor;Severities;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;Stomach;Structure;System;Testing;Time;Toll-like receptors;tumor progression;tumorigenesis;Type IV Secretion System Pathway;Validation;Viral

PROJECT_TITLE: Helicobacter Pylori and Gastrointestinal Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The overarching goal of the proposed Tisch Cancer Institute (TCI)-Mentored Medical Student Summer Scholar (TCI-MMSSS) Program is to inspire medical students to pursue careers in cancer research through engagement in an innovative, highly structured program of strongly mentored research projects and interactive curricular activities. Our program leverages institutional strengths in novel pedagogy and curricular innovation as well as the seasoned mentoring capacity and research expertise of the TCI Scientific Programs in Cancer Immunology, Cancer Mechanisms, Cancer Clinical Investigation, Cancer Prevention and Control, and Health Equity and Health Disparities. Our outstanding cadre of exceptional mentors, enthusiastic pool of diverse and compelling students and academically rigorous and innovative training environment will accelerate the development of the next generation of MD physician scientists committed to meaningful and clinically impactful cancer investigation.

PI_NAMEs: FERRARA, JAMES L. M.;GABRILOVE, JANICE L (contact);LIN, JENNY J.

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acceleration;AIDS related cancer;anti-cancer research;Basic Science;Cancer Control;cancer prevention;career;Career Choice;Clinical;clinical investigation;Clinical Research;Communities;Complement;design;Development;Education;educational atmosphere;Educational Curriculum;Ensure;Environment;Evaluation;experience;Exposure to;Fostering;Foundations;fundamental research;Funding;Future;Gastrointestinal Neoplasms;Goals;Health Disparities Research;health disparity;health equity;improved;innovation;Institution;interest;Investigation;Knowledge;Leadership;Liver;Lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Measures;Medical;Medical Education;medical schools;Medical Students;member;Mentors;Multiple Myeloma;Myeloproliferative disease;next generation;novel;Outcome;Participant;pedagogical content;pedagogy;Physicians;Population Research;pre-doctoral;Process;programs;recruit;Research;Research Project Grants;Resources;response;Scholars Program;Scientist;Seasons;skills;Structure;student participation;Students;success;summer student;Time;tool;Training;Translational Research;tumor immunology;United States National Institutes of Health

PROJECT_TITLE: TCI Mentored Medical Student Summer Scholars (TCI-MMSSS) Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Narrative Our proposed IRACDA program is a collaboration between the University of California at Santa Cruz (UCSC) and California State University at Monterey Bay (CSUMB), both Hispanic Serving Institutions in central California. The program aims to contribute to an increase in the number of underrepresented minorities in faculty positions in the biomedical field. UCSC postdoctoral scholars will receive rigorous research and teaching training by structured mentoring from UCSC and CSUMB mentors to ensure targeted career skill development; undergraduate STEM students at CSUMB will benefit from augmented mentoring by the IRACDA postdocs in classes and research settings, and by exposure to world class biomedical research.

PI_NAMEs: FORSBERG, CAMILLA  (contact);HINCK, LINDSAY E;SREENIVASAN, APARNA

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Achievement;Address;Area;Biology;Biomedical Research;California;career;Chemistry;Collaborations;design;Educational process of instructing;Educational workshop;Ensure;Environment;evidence base;Faculty;Feedback;Grant;hands on research;Hispanic-serving Institution;Interview;Laboratories;Laboratory Research;Leadership;lectures;Mentors;Mentorship;Mission;National Institute of General Medical Sciences;pedagogy;Positioning Attribute;Postdoctoral Fellow;programs;Reproducibility;Research;research and development;responsible research conduct;Science;skills;stem cell biology;STEM research;Structure;Students;success;summer research;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: IRACDA at UCSC and CSUMB

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: This grant application will investigate how truncated O-glycans on oncogenic glycoproteins promote pancreatic cancer progression and metastasis. Specifically, it will elucidate the role of Core 1 β1, 3-Galactosyltransferase (C1GALT1) in aberrant glycosylation of membrane-bound mucins and cancer stem cell markers and induce the early onset of metastasis in pancreatic cancer. Success in this study can be translated clinically by developing therapeutics (glycopeptide vaccines), and quantitative evaluation of truncated carbohydrate antigens in pancreatic cancer tissue can predict disease severity and help better manage pancreatic cancer patients.

PI_NAMEs: BATRA, SURINDER K.;PONNUSAMY, MOORTHY P. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acceleration;Acetylgalactosamine;Affect;Antigens;Appearance;Applications Grants;Binding;Cancer Etiology;cancer stem cell;carbohydrate structure;Carbohydrates;CD44 gene;Cessation of life;Clinical;clinical diagnosis;clinically significant;Co-Immunoprecipitations;CRISPR/Cas technology;Data;Death Rate;design;Disease;Disease Progression;Distant;Distant Metastasis;early onset;Galactose;Galactosyltransferases;Glycobiology;Glycopeptides;Glycoproteins;glycosylation;glycosyltransferase;Goals;Histocytochemistry;Human;improved;in vivo;Incidence;insight;Knock-out;KPC model;KRASG12D;Lectin;Liver;Lung;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Modeling;Molecular;Molecular Weight;mouse model;Mucin 1 protein;Mucins;Mus;Mutation;Neoplasm Metastasis;Normal Cell;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;O-Glycans Biosynthesis Pathway;Oncogenic;Organ;Organoids;pancreatic cancer cells;pancreatic cancer patients;Pathway interactions;Peptides;Peritoneum;Play;Polysaccharides;prevent;Quantitative Evaluations;Role;Sampling;Severity of illness;sialylation;stem cell biomarkers;stemness;Structure;success;sugar;Testing;Therapeutic;Tissues;TP53 gene;transcriptome sequencing;Translating;tumor progression;tumorigenesis;Tumorigenicity;Vaccines;Variant;Vertebral column

PROJECT_TITLE: Truncated O-glycan-dependent mechanisms inducing metastatic dissemination in pancreatic cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project narrative: Lyme disease remains an important public health issue. This work will identify the functional determinants of outer surface protein C, an essential virulence factor required for the ability of the Lyme disease spirochete to transmit from ticks and establish infection in mammals. The outcome of these analyses will enhance our understanding of the molecular mechanisms of pathogenesis for these important pathogens and provide information that can be exploited in the develop of improved preventive and therapeutic strategies for Lyme disease.

PI_NAMEs: MARCONI, RICHARD T (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affinity;Alleles;Amino Acid Substitution;antigen diagnostic;Binding;Biological;Birds;Borrelia;Borrelia afzelii;Borrelia burgdorferi;Borrelia burgdorferi Group;Borrelia garinii;Charge;citrate carrier;Classification;companion animal;Complement;Complement 4b;Coupled;Data;Dimerization;Distal;Electrostatics;enzootic;Extracellular Matrix;genetic approach;Genome;Human;improved;in vivo;Incidence;Individual;Infection;innovation;Ixodes;Kinetics;Ligand Binding;Ligand Binding Domain;Ligands;Link;Lyme Disease;Maintenance;Mammals;Mediating;Membrane;Molecular;Mus;mutant;Mutate;Organ;Oryctolagus cuniculus;OspA protein;OspC protein;Outcome;pathogen;Pathogenesis;Pathogenicity;Plasminogen;Play;Positioning Attribute;Preventive;Property;Proteins;Public Health;Recombinant Proteins;Research;Role;Site-Directed Mutagenesis;Solvents;Structure;Testing;Therapeutic;tick population;tick transmission;Tick-Borne Diseases;Ticks;tissue tropism;Transgenic Organisms;vaccine development;Variant;Virulence Factors;Work

PROJECT_TITLE: OspC and its role in defining host range and dissemination properties

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: CENTER OVERVIEW: PROJECT NARRATIVE This P30 renewal application from the Stanford Diabetes Research Center (SDRC) seeks support for its efforts to discover, apply and translate science about diabetes and it complications, with the goal of improving health by reducing the burden of diabetes. The SDRC was founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes at Stanford University, which has a tradition and reputation for scientific innovation and clinical care, located in the heart of Silicon Valley, an epicenter of transformative discovery and calculated risk-taking. Renewal of this P30 application will leverage diabetes research at Stanford University by providing key resources to support Research Cores, maintain a highly successful SDRC Pilot and Feasibility Award Program, creation of a Regional Pilot and Feasibility Award program to foster innovative diabetes research at the University of California (UC) Berkeley and UC Davis, and Enrichment Programs focused on diabetes research, education and care.

PI_NAMEs: KIM, SEUNG K (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Abbreviations;Acceleration;Affinity;ATAC-seq;Automobile Driving;Award;Awareness;base;Basic Science;Behavioral Sciences;Biological Assay;Biological Sciences;Biology;Biomedical Engineering;Biomedical Research;California;Cardiovascular system;care outcomes;Caring;Chemistry;chimeric antigen receptor T cells;Chromatin;chronic pancreatitis;Clinical;clinical care;clinical center;clinical development;Clinical Research;Clinical Trials;Clinics and Hospitals;Collaborations;Communities;Community Healthcare;Complications of Diabetes Mellitus;Dedications;Development;Diabetes Mellitus;Diagnosis;Direct Costs;Discipline;Education;Education and Outreach;Engineering;Event;Evolution;Faculty;Focus Groups;Fostering;Foundations;Funding;Future;genome wide association study;Genomics;Goals;Growth;Health;Heart;Human;Immunologic Monitoring;Immunology;improved;innovation;Institution;Insulin-Dependent Diabetes Mellitus;International;Investigation;islet;Kidney;Kidney Diseases;Knowledge;Leadership;Learning;Letters;Malignant neoplasm of pancreas;Maternal and Child Health;medical schools;Medicine;member;Mentors;Metabolism;Mission;Modernization;Modification;multidisciplinary;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pancreas;Pancreatic Adenocarcinoma;Pediatric Hospitals;Prevention;Principal Investigator;Productivity;programs;recruit;Regenerative Medicine;Research;research clinical testing;Research Institute;Research Personnel;Research Support;Resources;Risk Taking;Schools;Science;scientific organization;Scientist;Seminal;Services;Signal Transduction;Silicon;stem cell biology;Strategic Planning;Technology;Training;Translating;Translational Research;translational study;Translations;Transplantation;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Stanford Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Abbreviations;Administrator;Adolescent;Advocacy;Affinity;American;Atlases;Award;Awareness;base;Beta Cell;Biomedical Research;burden of illness;California;Cardiovascular system;career;career development;Cellular biology;Child Health;Childhood;chronic pancreatitis;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinics and Hospitals;Collaborations;Communication;Communities;Community Outreach;Complications of Diabetes Mellitus;control trial;diabetes control;Diabetes Mellitus;early-career faculty;Education;empowerment;Ensure;Environment;Equity;European;Event;Evolution;Fostering;Foundations;Funding;Future;Goals;graduate student;Grant;Growth;Health;Healthcare;Healthcare Systems;Hispanic Americans;Human;Immunity;improved;Infection;Institution;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Education;International;Internet;islet;Knowledge;lectures;Letters;Life;Link;Maintenance;Malignant neoplasm of pancreas;Medical;medical schools;Medical Students;member;Mentors;Metabolic;Metabolism;Mexican Americans;minority student;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;Obesity;operation;outreach program;Pancreas;Patient Care;patient oriented;Patients;Pediatric Hospitals;Postdoctoral Fellow;Productivity;programs;Public Health;randomized, clinical trials;Regenerative Medicine;Research;Research Institute;Research Personnel;Resources;Science;Scientist;Series;Societies;stem cell biology;symposium;Teacher Professional Development;Training;Training and Education;Training Programs;Translating;Translational Research;Transplantation;United States National Institutes of Health;Universities;Veterans Health Administration;web site

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Abbreviations;Aging;Alberta province;Area;Award;base;Biological Assay;Biology;Blood Cells;Blood Vessels;Body mass index;California;Canada;Cell Physiology;Cell Therapy;Cells;Child Health;chronic pancreatitis;Clinical;Collaborations;Communities;Complex;Coupled;Diabetes Mellitus;endocrine pancreas development;Ensure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Evolution;experimental study;falls;Functional disorder;Gene Expression Regulation;Genetic;Genome;Genomics;Glucagon;Growth;Healthcare;Hematopoietic stem cells;Human;Human Resources;human tissue;Immune;Immune Tolerance;Immunocompromised Host;Immunologic Monitoring;Immunologics;Immunology;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Investigation;investigator training;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Letters;Maintenance;Malignant neoplasm of pancreas;medical schools;member;Methods;Modeling;Modernization;Molecular;Mus;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Organ;Organ Procurements;Pancreas;Pathologic;Phenotype;Physiological;Procedures;programs;Proliferating;Publishing;Regulatory T-Lymphocyte;Research;Research Institute;Research Personnel;Rodent;San Francisco;Services;Signal Transduction;success;Training;translational potential;translational study;Transplantation;Universities;Virginia;Work

PROJECT_TITLE: Stanford Islet Research Core


PI_NAMEs: CHAIB, HASSAN  (contact)

PROJECT_TERMS: Abbreviations;Adoption;analytical method;applied biomedical research;Architecture;ATAC-seq;Award;Bioinformatics;Biological;Biological Assay;Cell Nucleus;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Structure;computerized tools;Consultations;cost;cost effective;Data;Data Analyses;design;Development;Diabetes Mellitus;DNA methylation profiling;Encapsulated;Equipment;Evolution;experimental study;Gene Expression Profiling;Genetic;Genome;genome sequencing;Genomic DNA;Genomic medicine;Genomics;Goals;Growth;Health;High-Throughput Nucleotide Sequencing;High-Throughput RNA Sequencing;Hour;Human;human disease;Human Microbiome;Individual;Informatics;innovation;Insulin-Dependent Diabetes Mellitus;islet;Laboratories;Libraries;medical schools;member;Modernization;new technology;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acids;Nucleotides;personalized medicine;portability;Preparation;programs;Regulatory Element;Research;Research Design;Research Personnel;Resources;Services;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Techniques;Technology;tool;Training;transcriptome sequencing;Transposase;Universities

PROJECT_TITLE: Diabetes Genomics and Analysis Core


PI_NAMEs: MAECKER, HOLDEN T. (contact)

PROJECT_TERMS: Abbreviations;Adult;Alpha Cell;Antigens;Antithymoglobulin;Archives;Autoantibodies;Award;base;Basic Science;Beta Cell;biobank;Biological Assay;Biology;Blood;Blood Cells;Blood specimen;Bone Marrow;California;Cell Death;cell killing;Cell Lineage;Cell Therapy;Cells;Cellular biology;Cellular Metabolic Process;chemokine;Child Health;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical center;Clinical Research;Clinical Trials;Clinics and Hospitals;Collaborations;Communities;Cryopreservation;cytokine;Data;Development;Diabetes Mellitus;diabetes risk;Dimensions;Donor person;Electronic Health Record;Ensure;Epigenetic Process;Etiology;Evaluation;Evolution;exome sequencing;Explosion;Feedback;Flow Cytometry;Frequencies;Functional disorder;Funding;Gene Modified;Genetic;Genomics;granulocyte;Growth;Healthcare;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high dimensionality;Human;human leukocyte antigen testing;Human Resources;human tissue;Immune;Immune response;Immune Tolerance;Immunity;Immunobiology;immunogenic;Immunologic Factors;Immunologic Monitoring;Immunology;Immunology procedure;Immunotherapy;improved;Infection;Inflammation;Inflammatory;instrumentation;Insulin-Dependent Diabetes Mellitus;interest;Investigation;investigator training;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Kidney;Leukocytes;Link;Living Donors;lymph nodes;lymphoid irradiation;medical schools;member;Methods;Microspheres;Mixed Lymphocyte Culture Test;Modernization;Molecular;Monitor;Myeloid Cells;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Pancreas;Pathologic;Pathology;Patient Monitoring;patient stratification;Patient-Focused Outcomes;Patients;pediatric patients;peripheral blood;Phenotype;Physiological;Plasma;Pre-Clinical Model;Process;programs;Reagent;Regulatory T-Lymphocyte;Research;Research Institute;Research Personnel;research study;Resources;response;Running;Sampling;Serum;Services;Signal Transduction;Spleen;Standardization;Study Subject;success;T-cell receptor repertoire;T-Lymphocyte Subsets;Technology;Testing;Therapy Clinical Trials;Time;Tissue Procurements;Tissue Sample;Tissues;tool;Training;transcriptome sequencing;Translational Research;Transplantation;Transplantation Tolerance;Universities;Work

PROJECT_TITLE: Diabetes Immune Monitoring Core


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: DESAI, MANISHA  (contact)

PROJECT_TERMS: Abbreviations;Address;advanced analytics;analytical tool;Animals;Award;Awareness;Basic Science;biobank;Biological Assay;Biomedical Research;California;Caring;Cells;Clinic;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Data;Clinical Investigator;Clinical Research;Clinical Trials;Collection;Communication;Computer software;Computerized Medical Record;Consent;Data;Data Analyses;Data Collection;data integrity;data management;Data Management Resources;Data Set;database design;design;Diabetes Mellitus;Diabetes prevention;Diagnosis;Disease;Disincentive;Education;electronic data;empowerment;Evolution;Failure;Fostering;Generations;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Growth;Healthcare;Human;human subject;human tissue;Immunologic Monitoring;improved;In Vitro;innovation;Institution;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;interdisciplinary collaboration;Interdisciplinary Study;International;islet;Knowledge;Laboratories;Link;Manuscripts;medical schools;Medicine;member;Metabolic;Methodology;Methods;Mission;Modernization;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ Procurements;Pediatric Hospitals;Phenotype;Procedures;Process;Productivity;programs;prospective;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resource Sharing;Resources;sample collection;Sampling;Science;Scientist;Services;Standardization;Strategic Planning;Support System;System;Technology;Testing;time use;Tissue Sample;Training;Translating;Translational Research;United States Food and Drug Administration;Universities;Work

PROJECT_TITLE: Diabetes Clinical and Translational Core


PI_NAMEs: KRAEMER, FREDRIC B. (contact)

PROJECT_TERMS: Abbreviations;Area;Award;Basic Science;Behavioral Research;Biomedical Research;California;career;career development;Clinics and Hospitals;Collaborations;Communities;Complications of Diabetes Mellitus;Core Facility;Data;Development;Diabetes Mellitus;Discipline;Elements;epidemiology study;Extramural Activities;Faculty;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;IACUC;innovation;Institution;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;International;Investigation;Knowledge;Leadership;medical schools;member;Mentorship;Mission;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Outcome;Peer Review;Persons;Prevention;Principal Investigator;Probability;Problem Solving;Productivity;programs;Publications;Published Comment;Research;Research Personnel;Research Proposals;Resources;Source;success;Sum;Text;Training Support;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Award Program


PROJECT_TERMS: Abbreviations;Area;Award;base;California;career;career development;Clinics and Hospitals;Collaborations;Communities;Core Facility;Data;Development;Diabetes Mellitus;Discipline;Extramural Activities;Faculty;Fostering;Foundations;Funding;Funding Mechanisms;Grant;IACUC;innovation;Institution;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;inter-institutional;interest;International;Investigation;Leadership;medical schools;member;Mentorship;Mission;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Peer Review;phrases;Prevention;Principal Investigator;Probability;Productivity;programs;Published Comment;Research;Research Personnel;Research Proposals;Research Support;Scientist;Text;Training;Training Activity;Universities;Work

PROJECT_TITLE: Expanded Pilot and Feasibility Award Program


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE In our group’s CSER NYCKidSeq project, we found the diagnostic success rate for children with autism to be only ~25% despite performing whole genome sequencing. Our preliminary studies for the current proposal have revealed de novo variants in children with these conditions to be enriched in the cis-regulatory regions of glial and neuronal cells, near genes implicated in these phenotypes, defining candidate pathogenic non-coding variants. My project will test these de novo variants for their molecular regulatory and cellular effects, combining chromatin and transcriptional studies and neural cell characterization in GABAergic neurons edited to introduce these variants, the foundation for improving our ability to understand the genetic causes of children with autism.

PI_NAMEs: SOSA, ERIC ALEXANDER (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Affect;Astrocytes;ATAC-seq;autism spectrum disorder;autistic children;Binding Sites;brain cell;Brain region;candidate identification;career;cell type;Cells;cellular engineering;Child;Chromatin;clinical diagnostics;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Code;cohort;Computational Biology;Data;Databases;de novo mutation;Diagnosis;Diagnostic;differentiation in vitro;disease phenotype;DNA;Doctor of Philosophy;Electrophysiology (science);exome;Family;Fellowship;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Diseases;Genetic Services;Genetic Transcription;genetic variant;Genome;genome editing;genome sequencing;Genomic approach;Genomics;Goals;human disease;Human Genetics;Human Genome;Impairment;improved;In Vitro;in vivo;Individual;individuals with autism spectrum disorder;induced pluripotent stem cell;insight;large datasets;Link;Location;Mediating;Medical;Medical Genetics;member;Membrane Potentials;Mentors;Minority Groups;Molecular;Neurodevelopmental Disorder;Neuroglia;Neurology;Neurons;neuroregulation;Neurosciences;Nucleic Acid Regulatory Sequences;offspring;Outcome;Parents;Pathogenesis;Pathogenicity;Patients;Phenotype;Physicians;Physiological;pre-doctoral;proband;Process;programs;Property;Regulation;Regulatory Element;Research;Role;Scientist;Signs and Symptoms;stem cells;success;Susceptibility Gene;synaptogenesis;System;Techniques;Testing;Tissues;tool;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Defining the gene regulatory roles of non-coding variants in the pathogenesis of autism


ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Lipid droplets are understudied cellular compartments that are integrally involved in cellular lipid storage and inherently connected to the etiology of numerous diseases such as prevalent metabolic diseases, heart disease, and cancer. The proposed research leverages innovative technological platforms to decipher the biology and regulation of lipid droplets.

PI_NAMEs: OLZMANN, JAMES A (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Anabolism;Antibacterial Response;Bacterial Infections;Biogenesis;Biology;Cardiovascular Diseases;Cell Line;Cell Physiology;cell type;Cells;Cellular biology;Communities;CRISPR screen;Custom;Data;Degradation Pathway;Diabetes Mellitus;Disease;Endoplasmic Reticulum;Etiology;Exhibits;experimental study;Family member;Fatty acid glycerol esters;Fatty Acids;Fluorescence;Foundations;Genes;Genetic Screening;genome-wide;genomic locus;Goals;Health;Heart Diseases;Hepatic;Hepatocyte;Histones;Homeostasis;Human;Hydrophobicity;Immune response;induced pluripotent stem cell;innovative technologies;insight;interest;Knowledge;Label;Libraries;Life Cycle Stages;lipid metabolism;Lipids;Lipolysis;Lipopolysaccharides;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Metabolism;monolayer;multicatalytic endopeptidase complex;Nerve Degeneration;Neurons;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;Obesity;Organelles;pathogen;pathogenic bacteria;Pathologic;Pathway interactions;perilipin;Peripheral;Pharmaceutical Preparations;Phenotype;Phospholipids;Play;prevent;programs;Proliferating;protein degradation;Proteins;Proteome;Proteomics;Regulation;Reporter;repository;Research;Resources;response;Role;Series;sterol ester;Surface;technology platform;Testing;Therapeutic;transcription factor;Triglycerides;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Validation;Viral

PROJECT_TITLE: Lipid droplet regulation and proteome dynamics

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ORG_CITY: GREENSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: PROJECT NARRATIVE Dioxygen is nature’s most powerful oxidant. It is activated and used by a variety of enzymes, such as coupled copper-only or copper/iron metalloenzyme active sites, to perform a diverse range of essential oxidative processes. Redox active aromatic amino acids, such as tyrosine (Tyr) or tryptophan (Trp), can serve as the source of protons and/or electrons and may carry out different tasks in the overall enzymatic mechanisms and functions of many of these enzymes. This proposal aims to determine the governing factors associated with the diverse roles these Tyr/Trp side chains adopt in each enzyme.

PI_NAMEs: HEMATIAN, SHABNAM  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Active Sites;Address;Adopted;Aerobic;Amino Acids;Aromatic Amino Acids;Biochemistry;Bioinorganic Chemistry;Cell Respiration;Coenzymes;cofactor;Copper;copper oxidase;Coupled;Couples;cytochrome c oxidase;design;Dioxygen;Electrons;enzyme mechanism;Enzymes;fundamental research;Iron;Life;Mediating;Metabolic;metalloenzyme;Metals;Molecular;Nature;Nuclear;Oxidants;oxidation;Oxidation-Reduction;Oxygen;Peptides;Planet Earth;Play;Positioning Attribute;Process;Protons;Reaction;Role;Side;Site;Source;Tryptophan;Tyrosine;Water

PROJECT_TITLE: Multinuclear Dioxygen-Utilizing Copper Enzymes: Diverse Roles for Aromatic Redox Active Amino Acids


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative (2-3 sentence re: public health relevance) With an estimated 2.87 million TBI-related emergency department visits each year in the United States, and approximately 69.1% of children ages 6-12 participating in sports annually, there is an urgent public health need to identify the process by which mTBI and RHI can lead to neurological health problems later in life. Once this process and modifying factors are identified, a comprehensive approach can be employed to mitigate adverse long-term outcomes, such as preventative health behavior interventions and the development of therapeutic treatments. Given this, the proposed research is relevant to the NIH's mission to enhance health, lengthen life, and reduce illness.

PI_NAMEs: BRETT, BENJAMIN L (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: advanced analytics;Age;age effect;Aging;Anisotropy;Anxiety;arterial spin labeling;Award;Behavior Therapy;Blood Vessels;Brain Concussion;brain health;burden of illness;cardiovascular risk factor;Cerebrovascular Circulation;Child;cohort;comorbidity;contact sports;Craniocerebral Trauma;Cross-Sectional Studies;Data;Data Set;design;Diet;Diffusion Magnetic Resonance Imaging;Emergency department visit;executive function;Exposure to;follow-up;General Population;Goals;head impact;Health;Health behavior;human old age (65+);Hybrids;Impaired cognition;improved;innovation;insight;Intervention;large scale data;Life;life span;Magnetic Resonance Imaging;Mediating;Mediation;Memory;Mental Depression;Mentors;Mentorship;Methods;mild traumatic brain injury;Mission;Molecular;Multicenter Studies;Nature;Nervous System Disorder;neurobehavioral;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologic;neuropathology;Outcome;pathological aging;Pathway interactions;Physical activity;Positioning Attribute;preventive intervention;Process;processing speed;programs;prospective;Public Health;public health relevance;Radial;Recording of previous events;Recurrence;Research;Risk;Risk Estimate;Risk Factors;Role;Severities;Site;Sports;Symptoms;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Training;United States;United States National Institutes of Health;Validation;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: The effects of cumulative concussion, repetitive head impacts, and comorbid cardiovascular risk factors on MRI metrics of pathological aging and neurobehavioral functioning across the lifespan

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The study aims to utilize high content systems to identify novel therapeutics for the treatment of necrotizing enterocolitis (NEC), a devastating gastrointestinal disease of premature infants. Using a well-characterized human microphysiologic intestine-on-a-chip platform, we have developed preclinical models of NEC, using both organoids and a “NEC-on-a-chip” model system derived from premature infant intestinal biopsies with patient- specific microbiota to recreate their cellular and microbial environment ex vivo. We will use these pre-clinical models of NEC as a neonatal gut-on-a-chip platform for high content drug testing and a precision medicine approach to this devastating disease.

PI_NAMEs: GOOD, MISTY L (contact);MAGNESS, SCOTT T

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 3-Dimensional;Address;Affect;antimicrobial;Automobile Driving;Bacterial Translocation;biobank;Biological Models;Biopsy;bisulfite sequencing;Cause of Death;Cell Death;Cell Differentiation process;cell injury;Cells;Childhood;Clinical;Coculture Techniques;cost;cost effective;cytokine;Data;Death Rate;design;Development;Devices;Disease;Dose;drug discovery;Drug Screening;drug testing;dysbiosis;efficacy evaluation;Endothelial Cells;Endothelium;Environment;epigenomics;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Excision;Failure;Functional disorder;Gastrointestinal Diseases;Genetic Transcription;Genome;genome-wide;Goals;high risk infant;Human;human disease;Hypermethylation;Immune;Immune response;Impairment;In Vitro;in vitro Model;Infant;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;innovation;insight;Intestinal Diseases;intestinal epithelium;Intestines;Knowledge;Libraries;Metadata;Methods;Methylation;microbial;microbiome;microbiome components;microbiota;Microfluidic Microchips;microphysiology system;Modeling;Morbidity - disease rate;Mucous body substance;multidisciplinary;multiple omics;Necrotizing Enterocolitis;Neonatal;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organoids;Pathogenesis;Pathogenicity;patient population;Patients;Peristalsis;Pharmaceutical Preparations;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;precision medicine;Preclinical Testing;Predisposition;premature;Premature Infant;Premature Infant Diseases;prevent;Process;Production;proteomic signature;regenerative;Research;Role;Safety;Scientist;screening;Specimen;Stretching;Supportive care;Surgeon;System;Testing;Therapeutic;therapeutic candidate;therapeutic evaluation;Tight Junctions;tool;Toxic effect;transcriptomics;Villus

PROJECT_TITLE: Neonatal gut-on-a-chip platform for high content drug testing and precision medicine


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Pancreatic cancer has the lowest survival rates for any kind of cancer. The objective of this proposal is to understand the molecular basis by which RHAMMB promotes pancreatic cancer metastasis. This study will provide novel insight for understanding the biology of this devastating disease and will generate a strong mechanism-based framework for developing novel strategies that block metastatic progression of pancreatic cancer.

PI_NAMEs: DU, YI-CHIEH NANCY  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Biogenesis;Biological Assay;Biology;Biosensor;cancer cell;cancer type;Cell Line;cell motility;Cells;Complex;Data;Diagnosis;Diagnostic Procedure;Disease;Disseminated Malignant Neoplasm;Dominant-Negative Mutation;effective therapy;Enzymes;Event;Fluorescence Resonance Energy Transfer;Genes;Genetically Engineered Mouse;Guanine Nucleotide Exchange Factors;Histologic;HMMR gene;Human;improved;In Vitro;in vivo;Incidence;insight;Invaded;Islet Cell Tumor;knock-down;KRAS oncogenesis;Length;Lipids;Lipolysis;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metastatic Neoplasm to the Liver;migration;Molecular;mouse model;mutant;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutic intervention;overexpression;pancreas xenograft;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;phosphoproteomics;prognostic;Prognostic Factor;programs;protein expression;Protein Isoforms;Publishing;receptor function;Reporting;RHAMM protein;rho;RNA Splicing;Role;Signal Pathway;Signal Transduction;Site;spheroids;success;Survival Rate;System;technique development;Testing;Therapeutic;therapeutic development;Translating;treatment strategy;tumor;Tumor Cell Line;tumor xenograft;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Receptor for hyaluronan-mediated motility isoform B (RHAMM B) in Pancreatic Cancer Metastasis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project narrative Hidradenitis suppurativa (HS) is a debilitating, inflammatory skin disease with few effective therapies. There has been a lack of well-powered genetic studies of HS. In this proposal, we use large genetic datasets, novel bioinformatics methods, and cutting-edge functional assays to identify and characterize HS genetic variants, which may lead to the identification of new therapeutic pathways in HS.

PI_NAMEs: LIAO, WILSON  (contact);MI, QING-SHENG ;POSCH, CHRISTIAN

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Abscess;Academia;Acceleration;Address;admixture mapping;Affect;African American;African American population;African ancestry;American;Architecture;Asian;Asian ancestry;Asian population;Atopic Dermatitis;Bioinformatics;Biological;Biological Assay;Buttocks;case control;Cell Communication;cell type;Cells;Chinese;Clinical Data;cohort;Collaborations;comorbidity;Cytometry;Data;Data Set;database of Genotypes and Phenotypes;deep sequencing;Deposition;Development;Disease;DNA;effective therapy;Emotional;Ethnic Origin;Europe;European;European ancestry;Exhibits;FDA approved;Foundations;Future;Genetic;genetic analysis;genetic architecture;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;genomic locus;Genotype;Grant;Hidradenitis Suppurativa;Immune;Immunobiology;Immunologist;immunopathology;Individual;Inflammatory;Inguinal region;innovation;insight;International;Knowledge;Latino Population;Link;Luciferases;Lupus;Mediating;meetings;Meta-Analysis;Methods;Minority;Morbidity - disease rate;multi-racial;Nodule;North America;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patients;Phenotype;Population;Predisposition;Prevalence;Proteomics;Psoriasis;Publications;Publishing;Race;racial difference;racial disparity;racial diversity;racial population;Registries;Reporter;Research Personnel;Resources;Risk;Sampling;Sarcoidosis;Severities;single-cell RNA sequencing;Sinus;Skin;skin barrier;skin disorder;Suspensions;Taiwan;therapeutic target;transcriptome;transcriptomics;treatment response;Untranslated RNA;Variant;Work

PROJECT_TITLE: Multi-racial genetic analysis of hidradenitis suppurativa


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Adoptive cell therapy (ACT) has demonstrated durable objective response in patients with solid tumors but has not been previously tested in patients with metastatic soft tissue sarcoma (mSTS). I will conduct a phase 1 trial of ACT in patients with mSTS where the safety of this regimen will be assessed as the primary endpoint and use tissue from this trial for laboratory investigations that evaluate the T-cell subsets responsible for tumor- specific activity and the genomic events of these tumors relative to the T-cell infiltration. I have also described career development goals that align with the scope of scientific work to ensure my successful transition from mentored junior faculty to independent surgeon-scientist with the ability to safely deliver clinical trials designed from my laboratory research.

PI_NAMEs: MULLINAX, JOHN  (contact)

PROJECT_TERMS: adaptive immune response;Address;Adoptive Cell Transfers;Advisory Committees;age group;Antitumor Response;Autologous;Award;Bioinformatics;Biological Assay;Biometry;Cancer Center;career;career development;CD8-Positive T-Lymphocytes;Cells;Cellular immunotherapy;Cervical;Cessation of life;Childhood;Chromosomal translocation;Clinical;clinical practice;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clonal Expansion;Coculture Techniques;Copy Number Polymorphism;Data;Development Plans;Diagnosis;Digestion;Doctor of Philosophy;Dose;early phase clinical trial;Ensure;Epithelium;Equine mule;Ethics;Event;experimental study;Faculty;falls;Fellowship;Funding;genomic data;Genomic Instability;Genomics;Goals;Grant;Histologic;immune cell infiltrate;Immunobiology;improved;In complete remission;in silico;Infusion procedures;Institution;Interferon Type II;Interleukin-2;Investigation;Investigational New Drug Application;Investigational Therapies;Laboratories;Laboratory Finding;Laboratory Research;Life;Literature;Lung;lymphocyte product;Lymphocyte Subtypings;Lymphocytic Infiltrate;Malignant Neoplasms;Measures;Mechanics;Melanoma;Memory;Mentors;Mesenchymal;Metastatic Melanoma;Methods;Molecular;Mutation;novel;Operating Rooms;Outcome;Pathogenesis;Pathologic;Pathology;Patient Selection;Patients;Phase I Clinical Trials;phase I trial;Point Mutation;Population;Positioning Attribute;pre-clinical;primary endpoint;Principal Investigator;Probability;productivity loss;Refractory Disease;Regimen;research and development;Resected;response;Role;Safety;safety and feasibility;safety assessment;safety testing;Sarcoma;Schedule;Scientist;secondary endpoint;Soft tissue sarcoma;Solid Neoplasm;Specimen;standard care;Surgeon;Surgical Oncology;T cell infiltration;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Therapy Clinical Trials;tissue resident memory T cell;Tissues;Training;Translating;trial design;tumor;Tumor Expansion;tumor growth;Tumor-Associated Process;Tumor-Infiltrating Lymphocytes;tumorigenesis;Work;Writing;young adult

PROJECT_TITLE: Leveraging the Lymphocytic Infiltration of Soft Tissue Sarcoma for Autologous Cellular Immunotherapy

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Lupus;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Women are dying from autoimmune disease at an alarming rate, and the National Institutes of Health identifies autoimmune disease as the top cause of morbidity among women in the United States. Current therapies for autoimmune diseases are dangerous and often ineffective, but development of new therapies is hampered by poor understanding of the mechanisms causing autoimmunity, including why women are so disproportionately affected. This project will define how the skin drives systemic autoimmune disease, identifying female-biased pathways and factors critical to autoimmunity in order to pave the way for new therapies to address this significant threat to public health.

PI_NAMEs: BILLI, ALLISON CHELSA (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Affect;American;Autoimmune Diseases;Autoimmunity;Automobile Driving;Award;Binding;Biological;career;career development;Cell Culture Techniques;Cell Nucleus;Cell Separation;cell type;Cells;Clinical;cofactor;Communities;Complex;Cutaneous;Cytoplasm;Dangerousness;Data;Dedications;Dermatology;Development;Development Plans;Disease;Disproportionately impacts women;Environment;Equipment;Ethics;Exanthema;falls;Family;Female;Fostering;Funding;Gene Expression Profile;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Goals;Grant;Growth;Human;human disease;human model;Human Resources;Immune;Immunology;Immunoprecipitation;improved;in vivo;Incidence;inhibitor;innovation;insight;International;Investigation;keratinocyte;knock-down;Knowledge;Laboratories;laboratory development;Leadership;Learning;lecturer;Lupus;lupus-like;male;Mass Spectrum Analysis;Mediating;Medicine;men;Mentors;Mentorship;Michigan;mouse model;Mus;Muscle Cells;Mutant Strains Mice;Myoblasts;new therapeutic target;novel;novel therapeutics;Nuclear;nucleocytoplasmic transport;Oncogenes;overexpression;Pathway interactions;Patients;Physicians;Positioning Attribute;Predisposition;prevent;Proteins;Proteomics;Public Health;public health relevance;Regulation;Regulatory Pathway;Research;research and development;Research Design;Research Personnel;Role;Scientist;sex;Sex Bias;Signal Pathway;skills;Skin;Small Interfering RNA;systemic autoimmune disease;Systemic Lupus Erythematosus;Systems Biology;targeted treatment;Testing;therapeutic target;Training;Transcription Coactivator;transcription factor;Transgenic Mice;Transgenic Organisms;Translational Research;United States;United States National Institutes of Health;Universities;Validation;Woman;women's morbidity

PROJECT_TITLE: Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Lung cancer is the leading cause of cancer death in the United States, with the major subtype being lung adenocarcinoma. The goal of our proposed research is to use genomic approaches to understand lung adenocarcinoma: how genome alterations in individual genes cause the disease, how we can find immunological targets, and how we can understand genome-wide structural alterations. I anticipate that the insights that we gain from this research could lead to new treatments for this deadly disease.

PI_NAMEs: MEYERSON, MATTHEW L. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: American;Aneuploidy;BRAF gene;cancer cell;Cancer Etiology;cancer genome;Cancer Patient;Categories;cell growth;Cell Proliferation;Cessation of life;Chromosomal Rearrangement;Clinical;Deaminase;Dependence;Diagnosis;Disease;DNA;effective therapy;Engineering;Epidermal Growth Factor Receptor;Epitopes;falls;functional genomics;Gene Amplification;Gene Dosage;gene function;Gene Mutation;Genes;Genetic Enhancer Element;Genome;Genome engineering;genome-wide;Genomic approach;Genomics;Goals;Human;Immune Targeting;Immunologics;Immunotherapy;improved;Individual;insight;Interferons;Knowledge;Laboratories;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Modification;mortality;Mutate;Mutation;new therapeutic target;novel;novel strategies;Nucleic Acid Cleavage;Oncogenes;Oncogenic;Pathogenesis;Pathway interactions;Persons;Prevention;Research;RNA;T-Lymphocyte;targeted treatment;Therapeutic;tool;Tumor Suppressor Genes;United States;Work

PROJECT_TITLE: Lung Adenocarcinoma: From Genome Alterations to Therapeutic Discovery


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Structural and mechanical deficiencies of the vaginal wall and supporting tissues are defining characteristics of pelvic organ prolapse, a common gynecologic condition. The aim of this study is to develop a mechanical and structural profile of vaginal tissue and use these parameters to inform design of a novel synthetic biomimetic graft for prolapse repair. We will perform experiments to phenotype the mechanical and structural properties of vaginal extracellular matrix, synthesize an elastomer-hydrogel graft that resembles healthy vaginal tissue, and examine cell attachment and differentiation on these grafts.

PI_NAMEs: EGNOT, MORGAN LEE (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: 3-Dimensional;3D Print;Adhesions;Adhesives;Adult;Behavior;Biochemical;Biocompatible Materials;Biological Assay;biomaterial compatibility;biomechanical test;Biomechanics;Biomimetics;Bioreactors;Cell Adhesion;Cell Culture Techniques;Cell Differentiation process;cell transformation;Cell-Matrix Junction;Cells;Characteristics;Clinical;Collagen Fiber;collagenase;Complication;Cues;Data;defined contribution;design;Development;DNA;Elastases;Elasticity;Elastin Fiber;elastomeric;Elastomers;Encapsulated;Engineering;Enzyme-Linked Immunosorbent Assay;Etiology;Excision;Exhibits;experience;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fiber;Fibroblasts;Fibrosis;Foundations;Future;Goals;Graft Enhancements;Gynecologic;Human;Hydrogels;Image;Immune response;immunogenic;immunogenicity;implant material;In Vitro;in vitro testing;interest;iterative design;Knowledge;manufacture;Measures;mechanical behavior;mechanical properties;Mechanical Stress;Mechanics;Microscopic;Microscopy;mimicry;Modeling;multiphoton microscopy;Myofibroblast;nonhuman primate;novel;Nulliparity;operation;Operative Surgical Procedures;Oryctolagus cuniculus;Pathologic;Pathology;pelvic organ prolapse;Peptides;Phenotype;Physicians;Physiological;Polypropylenes;Population;Porosity;Postoperative Complications;Predisposition;Procedures;Property;protein distribution;Proteins;Proteomics;prototype;Ptosis;Public Health;Reconstructive Surgical Procedures;Repair Material;repaired;Repeat Surgery;Research;response;Role;Sales;scaffold;Scientist;Side;Site;skills;Structure;success;surgery outcome;Technical Expertise;Techniques;Technology;Testing;Therapeutic;tissue repair;Tissues;Training;Transference;Vagina;Work

PROJECT_TITLE: Development of a Novel Bioinspired Pelvic Organ Prolapse Repair Graft

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Endocrine Disruptors;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_DEPT: PHYSICS

PHR: Project Narrative This proposal aims to develop a pipeline to screen and prioritize libraries of potentially toxic man-made chemicals found in the environment for further analyses, with particular emphasis on per- and poly-fluoroalkyl substances (PFAS) of which there are over 5000 currently known. Current environmental exposure testing methods evaluate mammary gland development in live mice because the mammary gland is highly susceptible to chemical exposure; yet, such methods are slow and expensive. Our proposal uses mammary cell culture models in increasingly complex, tissue-like environments, in combination with high-speed 3D optical imaging techniques, and ultimately compare the platform with a few candidate PFAS against existing data in live mice, setting the stage for future high-throughput screening of potential environmental toxicants.

PI_NAMEs: LOCKETT, MATTHEW RYEN;OLDENBURG, AMY L (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Animals;Architecture;assay development;Biological Assay;Biology;Biometry;Breast Cancer Epidemiology;Breast Epithelial Cells;carcinogenesis;carcinogenicity;Cell Culture Techniques;Cell Line;cell motility;Cells;Cellular Morphology;Characteristics;Chemical Exposure;chemical stability;Chemicals;Clinical Trials;Coculture Techniques;Complex;Data;data modeling;Data Set;deep learning;deep learning algorithm;Development;Endocrine Disruptors;Environment;Environmental Exposure;Epithelium;Estrogen receptor positive;Exposure to;Family;Fiber;Fibroblasts;Functional Imaging;Future;Genetic Markers;Gland;Growth;Health;high throughput screening;Hormones;imaging capabilities;Imaging Techniques;In Vitro;in vitro Assay;in vitro Model;in vivo;Incidence;Industrialization;intercellular communication;Invaded;Investments;Label;Libraries;Link;machine learning algorithm;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;malignant phenotype;mammary;mammary epithelium;Mammary gland;mammary gland development;man;Manufacturer;Mesenchymal;Methods;model design;Modeling;Molecular;Morphology;Motility;Mus;National Institute of Environmental Health Sciences;Nature;non-invasive imaging;North Carolina;novel;Odds Ratio;Optical Coherence Tomography;optical imaging;Optics;Output;Paper;Pathology;Physiological;Poly-fluoroalkyl substances;Predisposition;premalignant;Proliferating;Property;protein biomarkers;Public Health;Rattus;Research Personnel;Research Project Grants;Resources;response;Risk;Rodent;Rodent Model;S-Phase Fraction;Scanning;Scoring Method;screening;Signal Transduction;small molecule libraries;Speed;spheroids;Structure;System;Techniques;Technology;temporal measurement;Testing;three dimensional cell culture;three-dimensional modeling;Time;Tissue Model;Tissues;tool;Toxic Environmental Substances;toxicant;Up-Regulation;Visualization;Work

PROJECT_TITLE: Developing an in vitro to in vivo pipeline of mammary gland exposure-response relationships to per- and poly-fluoroalkyl substances (PFAS)

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative This project will examine the clinical outcomes and episode spending of patients with lower extremity injuries treated at a verified trauma center in the State of Michigan. We will identify the structures and processes of care that are key to achieving high quality outcomes with lower costs in the treatment of these patients. The results will have the immediate impact of creating a feedback mechanism to the trauma centers to improve care as well as inform subsequent policy for trauma center verification guidelines.

PI_NAMEs: OLIPHANT, BRYANT  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;Automobile Driving;Awareness;care coordination;care episode;career;Caring;Characteristics;Clinical;comorbidity;Comprehensive Health Care;Continuity of Patient Care;cost;Country;Data;data infrastructure;data registry;Data Set;demographics;Durable Medical Equipment;Economic Burden;Education;education planning;Environment;Essential worker;Evaluation;experience;Expert Opinion;Facilities and Administrative Costs;Feedback;Goals;Guidelines;health care delivery;Health Services;Health Services Research;Health system;Hospitals;Human Resources;improved;improved outcome;Individual;Infection;Injury;innovation;Inpatients;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lead;Length of Stay;limb injury;Link;Long term disability;Longterm Follow-up;Lower Extremity;Medical;Mentorship;Methods;Michigan;Minor;multidisciplinary;multilevel analysis;Orthopedic Surgery;Orthopedics;Outcome;Pain;Patient Care;Patient-Focused Outcomes;Patients;Physical therapy;Policies;population based;precision medicine;Process;programs;Provider;Registries;Rehabilitation therapy;Research;research and development;Research Personnel;Research Proposals;Resources;Risk Adjustment;Scientist;Severities;Site Visit;skills;Structure;Surgeon;System;tertiary care;Time;Training;Trauma;trauma care;trauma centers;Treatment Cost;Triage;United States;Variant;Work

PROJECT_TITLE: Trauma Center Characteristics that Drive Quality, Cost and Efficiency in Lower Extremity Injuries


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hematology;Liver Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: Ongoing gene therapy (GT) clinical trials employing AAV vectors to treat adult patients with hemophilia A (HA) have established the promise of GT for correcting hereditary bleeding disorders in adults, yet there are many advantages to offering these therapies early in life. The proposed studies will test the safety and efficacy of current GT approaches in the treatment of patients prior to birth and as neonates. If the advantage of this approach is unequivocally demonstrated, these patients could benefit from this important clinical option for treating genetic disorders.

PI_NAMEs: ALMEIDA-PORADA, GRACA DUARTE (contact);PORADA, CHRISTOPHER D

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;adeno-associated viral vector;Adult;Animal Model;Biological;biological adaptation to stress;Birth;Blood Coagulation Disorders;Blood Coagulation Factor;Capsid;Cell Proliferation;cell type;Cells;Clinical;Clinical Trials;clinically relevant;Clonal Expansion;Cross Presentation;cytokine;Data;Dose;Early treatment;Enzyme-Linked Immunosorbent Assay;Event;Exhibits;Exposure to;F8 gene;fetal;Fetal Development;Fetal Sheep;Fetus;Fibrosis;gene therapy;gene therapy clinical trial;Gene therapy trial;Gene Transfer;Genetic Diseases;Genome;genomic locus;Genomics;genotoxicity;Goals;Hemophilia A;Hemorrhage;Hepatocyte;Hepatotoxicity;Human;Immune;Immune response;Immune Tolerance;Immunity;Immunologics;in utero;in utero transplantation;in vivo;Incidence;Inflammatory Response;Inherited;inhibitor;Innate Immune Response;Intrauterine Blood Transfusion;Life;Liver;liver function;liver inflammation;Location;manufacturing run;Mediating;minimal risk;Neonatal;neonatal period;neonate;neutralizing antibody;Newborn Infant;Onset of illness;Organ;participant enrollment;Patients;Plasma;postnatal;pre-clinical;prenatal;prenatal exposure;prevent;Primary carcinoma of the liver cells;Production;Proteins;Recording of previous events;Risk;Safety;safety testing;Serotyping;Sheep;System;Testing;Therapeutic;Thymic epithelial cell;tissue tropism;Tissues;transgene expression;Transgenes;Treatment Efficacy;tumorigenesis;vector;vector genome;vector induced

PROJECT_TITLE: Defining the therapeutic efficacy, tolerogenic potential, and genotoxicity of liver-targeted AAV gene therapy for hemophilia A

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]