NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research is aim to address a crucial public health issue in a cost-effective manner because the aging of the Baby Boomer generation is resulting in a massive increase in the absolute number and proportion of elderly Americans. Metabolic impairment is the biggest risk factor for many diseases, leading to increased cost of healthcare. This project will develop new models to study hormonal signaling, cognitive aging and neurodegenerative diseases, and serve as a foundation for promising novel approach for the development of counter-neurodegenerative therapy.

PI_NAMEs: SUN, LIOU  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Age;age related;Aging;aging brain;aging process;Alzheimer's Disease;American;baby boomer;Behavioral;Brain;Cognitive aging;cost effective;Development;Disease;Elderly;extend lifespan;Foundations;Frontotemporal Dementia;Future;Gene Mutation;Generations;Genetic Models;Goals;Health Care Costs;healthspan;hormonal signals;hyperphosphorylated tau;IGF1 gene;Impairment;in vivo;Incidence;Intervention;late life;life span;Metabolic;model organism;Modeling;Molecular;mortality;Motor Neuron Disease;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;Neurodegenerative Disorders;new therapeutic target;novel;novel strategies;novel therapeutic intervention;null mutation;Parkinson Disease;Pathologic;Pathology;Pathway interactions;pharmacologic;Phenotype;Population;Predisposition;prevent;Process;Public Health;rate of aging;Research;Risk Factors;Rodent;Role;Secondary to;Signal Transduction;Somatotropin-Releasing Hormone;tau mutation;tau Proteins;Tauopathies;Testing;therapeutically effective;therapy development;Transgenes;Work;Yeasts

PROJECT_TITLE: Lifespan extension, Somatotropic signaling and Tauopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Food Allergies;Nanotechnology;Natural Products;Nutrition;Pediatric;Prevention

ORG_CITY: Briarcliff Manor

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GENERAL NUTRACEUTICAL TECHNOLOGY, LLC

ORG_STATE: NY

PHR: NARRATIVE Food Allergy is a serious and potentially life-threatening condition, affecting approximately 32 million people in the US, for which there is currently no cure. We developed an innovative berberine nanomedicine called NIT-X that showed excellent preclinical bioavailability, safety and nearly complete suppression of IgE and protection from peanut and tree nut anaphylaxis. NIT-X is not specific for any food and represents a novel food allergy treatment, even for those who suffer from multi-food allergies or have very high risk of reactions.

PI_NAMEs: LI, XIU-MIN ;YANG, NAN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: absorption;Accidents;Acute;Adult;Affect;Age;Amendment;American;Anaphylaxis;Animal Model;Annual Reports;anti-IgE;Antibodies;Area Under Curve;B-Lymphocytes;Berberine;Biochemistry;Biological Availability;Biotechnology;Body Surface;Botanicals;Categories;Chemistry;Child;Chronic;Clinical;Clinical Research;Clinical Trials;commercialization;common treatment;cost;Data;Dose;Double-Blind Method;drug development;Drug Kinetics;Encapsulated;Epithelial Cells;FDA approved;Food;food allergen;food avoidance;Food Hypersensitivity;Generations;Goals;Heavy Metals;Hematology;high risk;Histamine;Histology;Hypersensitivity;IgE;Immunity;Immunoglobulin A;Immunoglobulin G;immunoreaction;Immunosuppression;Individual;Industry;Inflammation;innovation;Interferon Type II;Interleukin-10;Interleukin-4;intestinal epithelium;Investigational Drugs;Laboratories;Life;manufacture;Marketing;mast cell;Mediating;medical schools;meetings;microbial;Morbidity - disease rate;mortality;mouse model;Mus;nano;nanomedicine;nanoparticle;novel;novel therapeutics;Nut Hypersensitivity;Nutraceutical;Nuts;omalizumab;Oral;oral immunotherapy;Outcome;Parents;Persons;Pesticides;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Phase;phase 1 designs;phase 2 designs;phase 2 study;phase I trial;Phase Ia Clinical Trial;Placebo Control;Placebos;Plasma;Plasma Cells;pre-clinical;preclinical safety;Preparation;Production;programs;prophylactic;protective effect;Proteins;Reaction;Research;Residual state;Risk;Safety;Sesame - dietary;Small Business Innovation Research Grant;small molecule;Solid;Technology;Teenagers;Testing;Therapeutic;Time;Toddler;Toxicology;transcriptomics;Trees;Work

PROJECT_TITLE: IgE Suppressing Berberine Nanomedicine for Treatment of Food Allergies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: CORE C – PROJECT NARRATIVE This core supports the research Projects with viral, cell- and animal-based experimental tools and models, but also conducts experiments. The infrastructure comprises collections of EBV+ and EBV- nasopharyngeal and gastric carcinoma cell lines, gastric organoid cultures, and cell-derived and patient-derived xenograft models - each reflecting different aspects of EBV-associated cancers. A major effort of Core C will be to test compounds targeting these cancers in support of Projects 1-3. In addition, the core will provide recombinant EBV to characterize the viral contribution to disease pathogenesis and drug responses.

PI_NAMEs: SOLDAN, SAMANTHA STANDISH (contact)

PROJECT_TERMS: Animal Cancer Model;Animal Model;Animals;ARID1A gene;Bacterial Artificial Chromosomes;bioluminescence imaging;cancer risk;Carcinoma;Cell Culture Techniques;Cell Line;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Development;Disease;Drug Combinations;Drug Screening;EBV-associated disease;Engraftment;Environment;Epigenetic Process;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Exclusion;experimental study;Fingerprint;gastric cancer cell;gastric organoids;Genes;genetic testing;genome integrity;Human;Human Herpesvirus 4;Human Resources;humanized mouse;imaging study;Immune;In Vitro;in vivo;in vivo Model;Infection;Infrastructure;Injections;Intervention;Knock-out;Label;Luciferases;Lymphoid Cell;Malignant Neoplasms;malignant stomach neoplasm;member;Metabolic;Metabolic Control;Methodology;Methods;Microsatellite Repeats;Mission;Modeling;mouse model;Mus;mutant;Nasopharynx;Nasopharynx Carcinoma;novel;Operative Surgical Procedures;Organ;Organoids;Pathogenesis;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;Physiological;Pre-Clinical Model;programs;recombinant virus;Recombinants;repository;research and development;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Services;Stomach;Stomach Carcinoma;System;Technology;Terminal Repeat Sequences;Testing;The Wistar Institute;Therapeutic;tool;TP53 gene;Training Programs;Tropism;tumor microenvironment;tumorigenesis;ultrasound;Universities;Variant;Viral;Virus;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Models of EBV Cancer


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The overall goal of my research program is to understand functional roles of noncoding variants in personal genome. Recent advent and development of whole genome sequencing data with paired multi-omics functional assays offer us a great opportunity to identify rare casual variants and individual-specific casual variants. I will develop a novel class of machine learning, statistical and system biology approaches for the identification, prioritization and interpretation of noncoding variants by integrating GWAS, WGS and multi- omics functional assays, which will empower precision medicine by identifying individualized biomarkers for disease prevention, diagnosis and treatment.

PI_NAMEs: CHEN, LI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Alzheimer's Disease;biobank;Biological Assay;Biomedical Research;Collaborations;Communities;computer framework;Computer Models;Computing Methodologies;Data;Development;Diagnosis;Dimensions;disorder prevention;empowerment;Genetic Medicine;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;Goals;Heritability;Human Genetics;improved;Indiana;Individual;interest;laboratory experiment;Linkage Disequilibrium;Machine Learning;Methodology;Methods;molecular phenotype;multidisciplinary;Multiple Myeloma;multiple omics;novel;open source;personalized biomarkers;Persons;Phenotype;Precision Health;precision medicine;programs;Quantitative Trait Loci;Research;Role;Sample Size;Scanning;Scientist;Software Tools;Statistical Methods;Systems Biology;Testing;Training;trait;transfer learning;Universities;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Computational modeling of genetic variations by multi-omics integration todecipher personal genome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Women's Health Research

ORG_CITY: LYME

ORG_NAME: REIA, LLC

ORG_STATE: NH

PHR: Project Narrative The purpose of this proposal is to optimize and prepare to commercialize a novel, collapsible vaginal pessary and applicator for the non-surgical treatment of pelvic organ prolapse (POP), a condition that symptomatically affects 3.7 million women in the United States. Recent medical studies suggest that surgical treatments for POP are less effective than once believed, and current pessaries in common use are limited by a rigid and fixed design, which can make them uncomfortable as well as difficult or impossible for patients to remove and insert independently. Consequently, there is an imperative to develop non- surgical treatment alternatives for women who suffer with POP which are easy to use, accepted, effective, comfortable, and cause minimal complications.

PI_NAMEs: HANISSIAN, PAUL  (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Address;Adoption;Affect;Age;alternative treatment;Biological;biomaterial compatibility;care delivery;care providers;Caring;Clinical;Clinical Trials;commercialization;Connective Tissue;cost;cytotoxicity;design;Development;Devices;Diameter;Drainage procedure;Enrollment;Equipment;Evaluation;evaluation/testing;Event;Excision;experience;feasibility trial;Female;Frequencies;Funding;Goals;Grant;Growth;Gynecologic;Hand Osteoarthritis;Health Care Visit;Home;impression;improved;innovation;irritation;Judgment;Laboratories;Left;manufacture;manufacturing environment;manufacturing facility;Marketing;Measures;Mechanics;Medical;Medical Device;Methods;microbial;Muscle;next generation;novel;open label;Operative Surgical Procedures;Organ;Outcome;pain reduction;Patients;Pelvic floor structure;pelvic organ prolapse;Persons;Pessaries;Phase;Physicians;Preparation;primary outcome;Process;product development;Production;Property;prospective;prototype;Ptosis;Quality of life;Randomized, Controlled Trials;Recommendation;Reporting;research and development;research clinical testing;Resources;secondary outcome;Self Management;Sex Functioning;Shipping;Small Business Innovation Research Grant;Specific qualifier value;standard care;standard of care;success;Surveys;Symptoms;System;Testing;treatment group;trial comparing;trial design;United States;United States National Institutes of Health;Uterus;Vagina;Vaginal Discharge;Validation;verification and validation;Visit;Woman

PROJECT_TITLE: Non-surgical treatment option for pelvic organ prolapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(11)B]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: We develop innovative causal inference methods grounded in health equity frameworks and apply these to estimate the impacts of Comprehensive Primary Care Plus on the health care of Black Medicare beneficiaries. We study variation in program impacts across subgroups with intersecting identities of gender, disability, and dual eligibility and across provider characteristics and environmental contexts. This proposal advances science and public health by enabling researchers to formulate causal questions, assumptions, and estimation methods appropriate for health equity evaluations.

PI_NAMEs: HATFIELD, LAURA ;MCWILLIAMS, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Examining payment and delivery model impacts on health equity using novel quasi-experimental causal inference methods

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


PHR: CORE D – PROJECT NARRATIVE The goal of the EBV Genomics and Bioinformatics Core D will be to provide an EBV-specialized functional genomic methodologies and integrative bioinformatics support to all research Projects within the Program. Core D proposes two Specific Aims: 1) develop and implement functional genomic approaches to study viral and host genomes and epigenomes using diverse Next Generation Sequencing (NGS) approaches; and 2) provide bioinformatic support for each Project through a centralize hub responsible for data management, quality control, analysis, and transfer within the program. The scope of service will include: 1) providing expertise and capabilities in genomic approaches including mRNA expression by RNA-seq, CHIP- and ATAC-seq library preparations, DNA methylation studies by RBBS, and HiC ; 2) ensuring seamless coordination of ‘omics’ efforts across projects as they develop new insights about EBV and performing integrative analyses to combine data from different experiments across the various projects; and 3) assisting with final reports, abstracts, manuscripts, and future funding proposals. Core D’s broad, long-term objective is: to provide leading-edge functional genomics and comprehensive bioinformatics and data management support for the Program members, and proper deposit in public database repositories.

PI_NAMEs: TEMPERA, ITALO  (contact)

PROJECT_TERMS: ATAC-seq;Bioinformatics;bisulfite sequencing;Carcinoma;Cell Culture Techniques;ChIP-seq;Chromatin Conformation Capture and Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Data Analyses;data exchange;data harmonization;data management;Data Security;Deposition;Development;DNA Methylation;Ensure;Environment;Epigenetic Process;epigenome;experimental study;functional genomics;Funding;Future;Generations;Genome;genome analysis;Genomic approach;Genomics;Goals;Human Herpesvirus 4;Hybrids;insight;Instruction;Libraries;Malignant Neoplasms;Manuscripts;member;Metabolic Control;Methodology;Methods;Modeling;mRNA Expression;Mus;next generation sequencing;Oncology;Organoids;Preparation;Procedures;Process;programs;Protocols documentation;public database;Quality Control;Reagent;Reporting;repository;Research;Research Personnel;Research Project Grants;RNA;Role;Sampling;screening;Services;small molecule;Technology;Testing;transcriptome sequencing;tumor;Viral;Visualization;Work;Writing;Xenograft procedure

PROJECT_TITLE: EBV Genomics and Bioinformatics


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite effective antiretroviral therapy, HIV-1 persists in cytotoxic CD4+ T lymphocytes and survives viral cytopathic effects and immune clearance. Using single-cell multi-omics profiling, we will examine how antigen responses and cytokine stimulation promote the persistence of HIV-1-infected, clonally expanding, cytotoxic CD4+ T cells. Our study will identity immune programs that drive HIV-1 persistence and guide HIV-1 eradication strategies.

PI_NAMEs: HO, YA-CHI  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Affect;analysis pipeline;anti-cancer research;Antigen Presentation;Antigens;antiretroviral therapy;Benzoxazoles;Bioinformatics;cancer cell;Carboxylic Acids;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell secretion;Cell Survival;Cells;Clonal Expansion;Clone Cells;cohort;cytokine;cytotoxic;cytotoxic CD8 T cells;Dimensions;Flow Cytometry;Frequencies;Genes;Genetic Transcription;Goals;Granzyme;Heterogeneity;HIV-1;Immune;immune clearance;In Vitro;in vivo;Individual;Infection;inhibitor;Machine Learning;Malignant Neoplasms;Measurement;memory CD4 T lymphocyte;multiple omics;perforin;Persons;polarized cell;Predisposition;preservation;prevent;programs;Proliferating;protein expression;Proteins;Research;Resolution;response;RNA;Sampling;Shapes;Specificity;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic development;therapeutic target;Time;TNF gene;tool;transcriptome;transcriptome sequencing;Tumor Necrosis Factor Therapy;Up-Regulation;Validation;Viral;Viral Cytopathogenic Effect;Viremia

PROJECT_TITLE: Understanding HIV-1 persistence in cytotoxic CD4+ T lymphocytes at the single cell level

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The purpose of this study is to examine EHR usability and usefulness in nurses in relationship to patient safety outcomes, at 3 sites using a human factors multi-methods approach. Data will include surveys, observations, interviews, real-time mobile monitoring, and EHR data analytics to relate usability/usefulness concerns to perceived missed nursing care and medication errors. From these data, patient safety analysis will be conducted that aims to reduce EHR burden, missed nursing care and medication errors.

PI_NAMEs: GURSES, AYSE PINAR;MILLER, ALISON HOPE (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: EHR usability and usefulness, perceived missed nursing care and medication errors in critical care

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative We recently showed that a single intravenous dose of an oncolytic Vesicular Stomatitis Virus encoding human interferon beta and the sodium iodide symporter imaging gene (VSV-IFNβ-NIS) is able induce shrinkage of multiple tumors in 5 patients (2 complete responses, 3 partial responses) with aggressive, treatment refractory TCL out of 10 that were treated. In this grant, we are seeking funding to increase this efficacy signal by combining virotherapy with immunotherapy to further improve therapeutic outcome and durability of clinical responses in patients with relapsed refractory TCL, as well as looking for factors that drive response in the patients.

PI_NAMEs: BENNANI, NABILA NORA;PENG, KAH-WHYE  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: anti-CTLA4;anti-PD-1;Antibodies;Antigens;Automobile Driving;biomarker identification;Biopsy;Blood;Blood Cells;Cells;Clinical;clinical development;Cytometry;Cytotoxic T-Lymphocytes;Disease remission;Dose;Dose Limiting;Engineering;Epitope spreading;exome sequencing;first-in-human;Foundations;Frequencies;Funding;Gene Expression Profile;Genes;genetic signature;Goals;Grant;Human;Image;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune response;Immunocompetent;Immunomodulators;immunotherapeutic virotherapy;Immunotherapy;improved;In complete remission;Interferon Type II;Interferon-beta;Intravenous;Intravenous infusion procedures;Kinetics;lymph nodes;Lymphoma;Malignant Neoplasms;Mediating;Mixed Neoplasm;Monitor;Multiple Myeloma;Mus;Mutation;neoplastic cell;next generation;Normal Cell;Oncolytic;oncolytic Vesicular Stomatitis Virus;Outcome;partial response;Patients;permissiveness;PET/CT scan;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Play;Population;Pre-Clinical Model;Refractory;Regimen;Regulatory T-Lymphocyte;Relapse;Reporting;responders and non-responders;response;Role;Safety;Signal Transduction;SLC5A5 gene;Specificity;Splenic Diseases;T cell receptor repertoire sequencing;T-Cell Lymphoma;T-Lymphocyte;Testing;therapy outcome;Time;Toxic effect;transcriptome sequencing;Treatment outcome;tumor;Tumor Antigens;tumor-immune system interactions;Vesicular stomatitis Indiana virus;Viral;Viral Genes;Virotherapy;Virus;Whole Blood

PROJECT_TITLE: Intravenous VSV virotherapy in lymphoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurodegenerative

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Uncorrupted gene expression is critical to cell function and human health. Our cells encode a multitude of RNA quality control machineries that detect and degrade defective RNAs that have the potential to interrupt gene expression, some of which have been linked to neurodegenerative disorders. The objective of this proposal is to uncover the mechanisms whereby these pathways detect and degrade defective RNAs in human cells, and the consequences of defects in these pathways to cell function and human health.

PI_NAMEs: LYKKE-ANDERSEN, JENS  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 7SL RNA;Address;Biological Assay;Cell Physiology;Cells;Code;Defect;Failure;Gene Expression;Genetic Transcription;Goals;Health;Human;human disease;Human Genome;insight;Interruption;Learning;Link;Mediating;Messenger RNA;Monitor;mRNA Decay;Mutagenesis;Neurodegenerative Disorders;Pathway interactions;Play;Predisposition;Proteins;Pseudogenes;Quality Control;Research;RNA;RNA Processing;Role;Signal Recognition Particle;Small Nuclear RNA;Spliceosomes;Untranslated RNA;Variant

PROJECT_TITLE: Mechanisms of human RNA turnover and quality control


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Salmonella enterica infections of humans in the industrialized world are typically accompanied by acute gastro- intestinal symptoms; while most patients make full recoveries from such acute infections, a small, but significant, proportion of patients (~5%, or about 100,000 patients annually in the US alone) develop a debilitating chronic inflammatory disease called Reactive Arthritis (ReA). As ReA is currently incurable and has limited treatment options, understanding how Salmonella and other enteric infections result in ReA, and whether the pathways involved in this process are therapeutically targetable, each represent important unanswered questions. Here, we identify ZBP1-driven necroptosis as driver of Salmonella-triggered ReA, outline studies to understand how this pathway contributes to disease, and describe ways in which it can be exploited for therapeutic benefit in ReA.

PI_NAMEs: BALACHANDRAN, SIDDHARTH  (contact);TUKEL, CAGLA

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;acute infection;Amyloid;Ankylosing spondylitis;Autoantibodies;Autoimmunity;B-DNA;Bacterial DNA;Bacterial Infections;Binding;Campylobacter;Cell Death;cell type;Cells;Cessation of life;Chronic;chronic infection;chronic inflammatory disease;Clinical;Complex;Disease;DNA;ds-DNA;enteric infection;enteric pathogen;Epithelial Cells;Fibroblasts;gastrointestinal symptom;Gastrointestinal tract structure;Generations;Genomic DNA;Human;IL17 gene;Immune;immunogenic;Individual;Industrialization;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Interferon Type I;intestinal epithelium;joint inflammation;kinase inhibitor;Left;Ligands;Mediating;Microbial Biofilms;model organism;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Nature;novel therapeutics;Nucleic Acids;Outcome;Pain;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphotransferases;Positioning Attribute;prevent;Preventive;Process;Production;Protein Secretion;Proteins;Reiter Disease;Reporting;response;RIPK3 gene;RNA;Role;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;sensor;Shigella;Signal Transduction;small molecule;Symptoms;systemic inflammatory response;Testing;Therapeutic;Therapeutically Targetable;Viral Proteins;Virus Diseases;Yersinia;Z-Form DNA

PROJECT_TITLE: Role of ZBP1 in pathogenesis of Salmonella biofilms


ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection)  The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a multi-center pragmatic randomized clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing routine post-discharge wound care to chlorhexidine bathing plus nasal decolonization in the 30 days following discharge. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.

PI_NAMEs: COHEN, STUART H.;HUANG, SUSAN S. (contact);KLEINMAN, KENNETH P.

PROGRAM_OFFICER_NAME: LIN, LEYI


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Dementia;Diabetes;Heart Disease;Neurodegenerative;Neurosciences;Nutrition

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Abnormal metabolism of sugars, fats, and related molecules is a central feature of human aging and plays major roles in age-related conditions like cardiovascular disease, diabetes, and dementia. Dr. Mukamal has undertaken broad-based epidemiological research on metabolic determinants of aging, including recent research to understand the health effects of fatty acids that circulate in the blood and affect organs throughout the body. The goals of this K24 award are to enable Dr. Mukamal to expand his knowledge in the measurement of dementia in large clinical studies of metabolism and to train new clinical investigators in research devoted to metabolic aging.

PI_NAMEs: MUKAMAL, KENNETH JAY (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Adipocytes;adjudication;Adult;Adverse effects;adverse outcome;Affect;age related;Aging;Alzheimer's disease related dementia;Atrial Fibrillation;Award;Biological Specimen Banks;Blood;blood-brain barrier crossing;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career;Cessation of life;clinical database;Clinical Investigator;Clinical Research;Cognitive;cognitive testing;cohort;Cohort Studies;Communities;Congestive Heart Failure;data resource;Dementia;Diabetes Mellitus;diabetes risk;Education;Educational Curriculum;Elderly;Environment;epidemiology study;Evaluation;Event;experience;Familiarity;Fatty acid glycerol esters;Fatty Acids;follow-up;frailty;Funding;Ginkgo biloba;Glucose;glucose metabolism;Goals;Health;high risk;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;instrumental activity of daily living;Internal Medicine;Internist;Israel;Knowledge;lipid metabolism;Lipolysis;Measurement;Medical center;medical schools;member;Memory;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;Metabolism;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;minority scientist;mortality;National Heart, Lung, and Blood Institute;neuroimaging;neuropsychiatry;next generation;older adult;Organ;Outcome;Participant;patient oriented research;Phenotype;Physical Performance;Play;Population;Population Study;Positioning Attribute;programs;Public Health Schools;radiological imaging;randomized trial;Research;Research Personnel;research study;Research Support;Residencies;response;Role;Scientist;Students;sugar;Testing;Training;Training Programs;Underrepresented Minority;Work;working group

PROJECT_TITLE: Mid-Career Research and Mentorship in Metabolic Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Projective Narrative Membrane remodeling governs essentially all neuronal functions including synaptic vesicle exocytosis and endocytosis. Defects in these processes lead to neurological disorders, and thus, mechanistic understanding is necessary. In this proposal, we will develop novel approaches in electron microscopy and leverages these tools to understand the millisecond-by-millisecond progress in membrane remodeling during synaptic vesicle cycle.

PI_NAMEs: WATANABE, SHIGEKI  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Behavioral;Defect;Electron Microscopy;Endocytosis;Event;Exocytosis;experimental study;insight;Lead;Mediating;Membrane;Membrane Lipids;millisecond;Molecular;Nervous System Disorder;Neurons;neurotransmission;novel strategies;Output;Play;Process;Proteins;Recording of previous events;response;Role;Signal Transduction;Speed;Stimulus;Synapses;Synaptic plasticity;Synaptic Vesicles;Techniques;Time;tool;trafficking;Visualization

PROJECT_TITLE: Ultrafast membrane trafficking at synapses


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Brewer The proteins and regulatory networks that choreograph genome replication are conserved across eukaryotes; through our study of genome replication in the yeast Saccharomyces cerevisiae, we have discovered that the timing of replication of the rDNA (the repeated locus that codes for the RNA component of ribosomes) is essential for coordinating genome replication with the exit from mitosis. We propose to continue our exploration of the temporal and spatial regulation of replication in yeast by focusing on the rDNA and on the proteins that define and regulate replication origins. This work will expand our basic understanding of the mechanisms regulating chromosome duplication and illuminate questions of importance to human health.

PI_NAMEs: BREWER, BONITA J (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Cell Cycle;Cells;chromosome replication;Chromosome Structures;Chromosomes;Code;Disease;DNA biosynthesis;Ensure;Eukaryota;event cycle;Genetic;Genome;Genome Stability;genome-wide;Genomics;Health;Human;Link;Maintenance;Malignant Neoplasms;Mission;Mitosis;Modeling;Monitor;Phenotype;Play;preference;Process;Proteins;Regulation;Replication Origin;Ribosomal DNA;Ribosomes;RNA;rRNA Genes;Saccharomyces cerevisiae;Site;System;Tandem Repeat Sequences;Time;Work;Yeasts

PROJECT_TITLE: Choreography of Eukaryotic DNA Replication

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Sexually transmitted infections (STI), including HIV infection, cause substantial morbidity and mortality. To reduce the impact of STI, researchers must be able to work in interdisciplinary teams that bridge basic science, clinical medicine, epidemiology, and social and behavioral sciences. This application proposes to provide training to predoctoral students and postdoctoral fellows, including physicians, to create a corps of researchers with the skills needed to decrease the burden of STI in the US and worldwide.

PI_NAMEs: SENA-SOBERANO, ARLENE C. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Training in Sexually Transmitted Infections and HIV

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Medicare coverage expansions for telehealth and increasing demand for telehealth services during the COVID- 19 pandemic have led to a surge in telehealth use in skilled nursing facilities (SNFs), which may impact the quality of post-acute care for Medicare beneficiaries. This project will examine telehealth its patients clinicians, used provision in SNFs and impact on utilization, cost, and quality of care among Medicare beneficiaries in SNFs, with a focus on with Alzheimer's disease and related dementias (ADRD) . Results will provide new evidence to payers and policymakers on the uptake and impacts of telehealth use in SNFs, how telehealth is in SNFs for patients with ADRD, and characteristics of SNFs associated with telehealth use. ,

PI_NAMEs: YU, JIANI  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acute;acute care;Address;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;asynchronous encounter;Award;beneficiary;Caregivers;Caring;Characteristics;Clinical;Communities;comorbidity;Consultations;cost;COVID-19;COVID-19 pandemic;Cues;Data;design;Discipline of Nursing;Educational workshop;Effectiveness;Emergency department visit;Fee-for-Service Plans;Funding;Goals;Growth;Health;health care delivery;Health care facility;health care service utilization;Health Services;hospital readmission;Hospitalization;hospitalization rates;Improve Access;improved;innovation;insight;Intention;Interview;Investments;Knowledge;Length of Stay;Level of Evidence;medical specialties;Medicare;Mentors;Mentorship;Methods;Modality;multidisciplinary;novel;Nursing Services;nursing skill;older adult;Outcome;Outpatients;Patient Care;Patients;Pattern;Persons;Physician Executives;Policies;Policy Maker;Population;Process;programs;Provider;Quality of Care;Quasi-experiment;rehabilitation service;Research;Research Personnel;response;Role;Rotation;Services;Skilled Nursing Facilities;socioeconomics;Structure;Technology;telehealth;telehealthcare;tool;Training;Training Activity;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;uptake;Variant;Visit;Visual

PROJECT_TITLE: Examining Telehealth Use in Skilled Nursing Facilities, with a Focus on Patients with Alzheimer's Disease and Related Dementias

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Interstitial Cystitis;Neurosciences;Pain Research;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: The proposal addresses the trans-NIH Pain Consortium's mission to understand the transition from acute to chronic pain conditions, using a widely accessible study framework- women with menstrual pain. A longitudinal virtual study, using health assessments, symptom questionnaires, and a bladder test will identify which women are at risk for later development of chronic pelvic pain conditions. Those results, combined with data gathered from additional in-person sensory tests, brain activity measures, and inflammation assays, are likely to create a prevention paradigm, centered around identified, modifiable factors for the development of chronic pelvic pain.

PI_NAMEs: TU, FRANK FU-SHENG (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acceleration;Accounting;Acute;Address;Afferent Neurons;aged;Animals;Anti-Inflammatory Agents;Biological;Biological Assay;Bladder;bladder pain;Blood;Brain;care costs;Chronic;chronic pain;chronic pain patient;chronic painful condition;chronic pelvic pain;Clinical;cohort;Collection;Communication;cost;Data;density;Development;Distress;Dysmenorrhea;Early Intervention;effective therapy;Electroencephalography;endometriosis;Equipment and supply inventories;Event;Event-Related Potentials;Exhibits;experience;follow-up;Follow-Up Studies;Functional disorder;Health;health assessment;high risk;High Risk Woman;Home;Hypersensitivity;Impairment;Inflammation;Inflammatory;Inflammatory Response;innovation;Interstitial Cystitis;Irritable Bowel Syndrome;Knowledge;Leukocytes;Longitudinal Studies;Longitudinal, observational study;Measurement;Measures;Mediating;Methods;mindfulness meditation;Mission;multimodality;Natural History;neural;Neurobiology;Neurologic;neuromechanism;Non-Visceral;Organ;Outcome;Pain;pain chronification;Pain Disorder;Pain Free;pain outcome;pain sensitivity;pain symptom;Participant;Pathway interactions;Patients;Pelvic Pain;Pelvis;Perception;Persons;Phenotype;Pilot Projects;Populations at Risk;predicting response;prevent;Prevention;Prevention strategy;productivity loss;prospective;Prospective Studies;psychologic;Psychophysics;public health priorities;Quality of life;Questionnaires;Recording of previous events;reproductive;response;Risk;Sampling;screening;Sensory;Severities;Spinal;Symptom Burden;symptomatology;Symptoms;System;systemic inflammatory response;Testing;Time;TLR4 gene;two-dimensional;United States National Institutes of Health;virtual;Visceral;Whole Blood;Woman;Women's study;young woman

PROJECT_TITLE: Cross Organ Mechanisms in Chronic Pelvic Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Opioid use disorder (OUD) worsens the CNS injury seen in neuroHIV, and although excitotoxicity is a critical component of HIV and/or opiate-driven injury, our evidence suggests that a loss of inhibitory control contributes significantly to this damage since ‘disinhibition’ results in net excitation. We have shown that certain behavioral deficits and structural changes in neurons can be reversed when [Cl−]i balance inside of striatal neurons is stabilized by restoring activity of the K+-Cl− symporter KCC2. The proposed studies explore this theory about the mechanisms underlying synaptodendritic dysfunction/injury in neuroHIV-OUD comorbidity by systematically exploring Cl− regulation using electrophysiological, structural, optical imaging, and behavioral measures in 2 complementary transgenic models and in cultured murine and human cells, with multiple interventional approaches.

PI_NAMEs: HAUSER, KURT F (contact);KNAPP, PAMELA E

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Affect;Agonist;AMPA Receptors;Animals;Architecture;autism spectrum disorder;awake;Behavior;behavior measurement;Behavioral;Biochemical;Brain;Brain-Derived Neurotrophic Factor;Breeding;Cell membrane;Cells;central nervous system injury;Chronic;CLC Gene;Clinical Pathology;cohort;comorbidity;Contracts;Corpus striatum structure;cytokine;Data;deafness;Disinhibition;Dopamine Receptor;driving force;Electrophysiology (science);Enhancers;Epilepsy;Equilibrium;Event;excitotoxicity;experimental study;Exposure to;Functional disorder;genetic regulatory protein;Glutamates;Gramicidin;Heroin;HIV;HIV Envelope Protein gp120;HIV-1;Homeostasis;Human;human induced pluripotent stem cells;Immunosuppression;Impaired cognition;In Vitro;in vitro Model;in vivo;Incidence;induced pluripotent stem cell;Infection;Inflammation;inhibitor;injection drug use;Injury;innovation;Intervention;Intractable Epilepsy;Link;Membrane Potentials;Minor;Morphine;motor behavior;motor deficit;Mus;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;neuroAIDS;Neuroglia;Neurologic;neuronal excitability;Neuronal Injury;neuronal survival;Neurons;neurotoxic;Opiate Addiction;Opioid;opioid abuse;opioid exposure;Opioid Receptor;opioid use disorder;optical imaging;Optics;Outcome;Output;painful neuropathy;patch clamp;Pattern;Perforation;Phosphorylation;Physiological;Physiology;Population;Probability;Prodrugs;Property;Proteins;Ramp;Regulation;Reporter;Rest;Role;Severities;sex;Signal Transduction;sodium-potassium-chloride cotransporter 1 protein;spinal cord and brain injury;Spinal cord injury;symporter;System;Temporal Lobe;Testing;theories;Therapeutic;Therapeutic Intervention;therapy design;trafficking;Transgenic Mice;Transgenic Model;transmission process;uptake;voltage

PROJECT_TITLE: Innovative therapeutic approaches to address excitotoxic CNS/neuronal damage in opioid-neuroHIV comorbidity


NIH_SPENDING_CATS: Aging;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: At the end of the support period, our experiments should begin to provide groundbreaking insights into how mouse immune aging can best mimic human immune aging, and how repeated daily stressors influence reactivation of, pathogenesis by and immunity against mCMV and the overall immune function in in old organisms. Information will pave way to specific immune interventions against CMV and immune (and, perhaps, general) aging in older adults.

PI_NAMEs: NIKOLICH, JANKO Z. (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Acute;Address;Adult;Age;age related;Aging;Animals;Antigens;Award;B-Lymphocytes;Biological Models;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cell Count;Cells;Chemicals;chronic infection;Communicable Diseases;Corticosterone;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Disease;Disparate;Dissection;DNA biosynthesis;Dose;Drops;Elderly;Emotional;Ethics;Evaluation;Exhibits;experience;experimental study;Exposure to;Frequencies;germ free condition;Grant;Hand;Health;healthspan;Herpesviridae Infections;Homeostasis;Hormones;Human;human old age (65+);Immune;immune function;Immune system;Immunity;Immunologic Stimulation;Immunologic Tests;immunological intervention;Immunologics;immunosenescence;Impairment;improved;Inbreeding;Individual;Infection;inhibitor;insight;Intervention;Ionizing radiation;irradiation;Knowledge;Label;Laboratories;Laboratory mice;late life;Life;Life Expectancy;life span;Maintenance;Measures;Memory;microbiome;microbiota;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Murid herpesvirus 1;Mus;Myeloid Cells;neonatal human;novel;older adult;Organism;Outcome;pathogen;Pathogenesis;physiologic model;physiologic stressor;Physiological;Plaque Assay;Production;psychologic;Psychosocial Stress;response;Stimulus;Stress;stressor;System;systemic inflammatory response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;timeline;tool;Vaccination;vaccine immunogenicity;valacyclovir;Viral;Virus;Virus Diseases;Virus Replication;West Nile virus

PROJECT_TITLE: T Cell Homeostasis and Function in Immune Senescence

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE To reach HIV-uninfected pregnant and breastfeeding women in South Africa, who are at very high risk of HIV acquisition, we will test a new and innovative package of interventions: 1) pre-exposure prophylaxis (PrEP), which is both safe and effective for preventing HIV in pregnant and breastfeeding mothers; 2) HIV self-testing for the participant and her partner(s); and 3) enhanced adherence counseling combined with home-based PrEP delivery for women who have difficulties with regular PrEP use. Our study will be among the first ever to evaluate the efficacy and cost-effectiveness of a PrEP intervention among pregnant and postpartum women and will play a key role in informing maternal PrEP interventions to eliminate HIV acquisition and transmission to partners and their infants.

PI_NAMEs: JOSEPH DAVEY, DVORA LEAH (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Africa South of the Sahara;AIDS prevention;antenatal;antenatal care;arm;Behavioral Sciences;Biofeedback;Biological Assay;Breast Feeding;California;Caring;Clinic Visits;Clinical;Collection;comparison intervention;Consolidated Framework for Implementation Research;cost effectiveness;cost-effectiveness evaluation;Counseling;design;Diagnostic Reagent Kits;Diphosphates;disability-adjusted life years;Drops;economic evaluation;Effectiveness;efficacy evaluation;Eligibility Determination;empowerment;Enrollment;Epidemiology;Equity;Fertility;Frequencies;Guidelines;Health care facility;health economics;Health Personnel;Healthcare;High Prevalence;high risk;High Risk Woman;HIV;HIV Infections;Home;Human immunodeficiency virus test;improved;Incidence;incremental cost-effectiveness;Infant;innovation;Intervention;intervention participants;Interview;lateral flow assay;Lead;Link;Los Angeles;male;Measures;microcosting;Modeling;Monitor;Mothers;novel;novel strategies;Participant;Partner Communications;Patient Self-Report;Pharmaceutical Preparations;Pilot Projects;Play;point of care;Policies;Postnatal Care;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;pregnant;Pregnant Women;prevent;preventive intervention;primary outcome;programs;Provider;Randomized, Controlled Trials;Research;Risk;routine care;Safety;secondary outcome;self testing;Services;South Africa;standard of care;Surveys;Tenofovir;Testing;testing services;Time;Translating;transmission process;treatment arm;Universities;Urine;Vertical Transmission;Visit;Woman;Work

PROJECT_TITLE: Stepped care to optimize PrEP effectiveness in pregnant and postpartum women (SCOPE-PP) in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Magnetic resonance imaging (MRI), including elastography (MRE), is a promising technology for the non- invasive assessment of non-alcoholic fatty liver disease (NAFLD), but still cannot reliably distinguish simple steatosis from non-alcoholic steatohepatitis (NASH) - the severe form of NAFLD that can lead to fibrosis, cirrhosis, and even death. This project will develop a new suite of rapid and robust free-breathing quantitative MRI techniques in combination with multi-parametric deep learning models to accurately classify simple steatosis versus NASH and measure the degree of fibrosis. The new MRI and deep learning technologies will be validated and tested in patients with NAFLD, ranging from simple steatosis to NASH, to characterize the classification performance and establish a framework that can be used in the future to improve management of patients with NAFLD.

PI_NAMEs: ALTBACH, MARIA I.;DESHPANDE, VIBHAS ;WU, HOLDEN H (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Abdomen;Acceleration;Adoption;Area;Arizona;Attention;Biological Markers;Biomedical Engineering;Biopsy;Breathing;California;Cells;Cessation of life;Characteristics;chronic liver disease;Cirrhosis;Classification;Clinic;Clinical;Compensation;contrast enhanced;Data;deep learning;deep learning model;density;Detection;Development;Diagnosis;Disease;disease classification;Early Diagnosis;elastography;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Future;Goals;Health Care Costs;Hepatic;hepatocyte injury;Image Enhancement;image processing;improved;Inflammation;Interdisciplinary Study;Interobserver Variability;Iron Overload;Joints;Label;Life;Liver;liver biopsy;Liver Failure;Liver Fibrosis;liver inflammation;Liver parenchyma;Los Angeles;Magnetic Resonance;Magnetic Resonance Elastography;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Medical Imaging;Modeling;Monitor;Morbidity - disease rate;Morphologic artifacts;Motion;MRI Scans;new technology;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Outcome;Patients;Performance;Perfusion;Physics;Primary carcinoma of the liver cells;prospective;prospective test;Protocols documentation;Protons;Radial;reconstruction;Reproducibility;Research;Risk Factors;ROC Curve;Sampling Errors;Scanning;Scheme;sensor;Signal Transduction;simple steatosis;Staging;Techniques;Technology;Testing;Time;Tissues;Training;treatment response;Uncertainty;Universities;Validation;Water

PROJECT_TITLE: Quantitative MRI and Deep Learning Technologies for Classification of NAFLD

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The proposed study will determine the expected economic benefit from a prevention delivery and support system for evidence‐based preventive interventions (EBPIs) known as PROSPER (PROmoting School/community‐university Partnerships to Enhance Resilience) that has been shown to increase efficiencies for intervention delivery as well as cultivate sustainable funding streams to support long-term dissemination. Economic impact will be based on administrative data and other markers of well-being measured as participants are followed into adulthood, following up on already demonstrated project effects for reduced substance misuse as well as reduced rates of conduct disorder among adolescents. Importantly, this investigation will assess the expected variation in economic impact due to study implementation factors measured in detail in prior work, enabling further information for how resources may be most efficiently expended for the sake of prevention of long-term problems related to early substance misuse.

PI_NAMEs: CROWLEY, DANIEL MAX (contact);JONES, DAMON

PROGRAM_OFFICER_NAME: VAN VOORHEES, COURTE CHRISTIAN WIRTH

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;alcohol misuse;Budgets;Characteristics;cohort;Communities;community academic partnership;community intervention;Conduct Disorder;cost;Cost-Benefit Analysis;Costs and Benefits;Country;COVID-19 pandemic;Criminal Justice;Data;design;economic evaluation;economic impact;economic implication;economic outcome;Economics;Education;Effectiveness of Interventions;Employment;Environment;evidence base;Expenditure;Family;Funding;Future;Health;health service use;Healthcare;high risk;Human;implementation determinants;improved;Individual;Infrastructure;intervention delivery;intervention effect;intervention participants;Investigation;Investments;Link;Local Government;Long-Term Effects;Marijuana;Marketing;Measures;Medicaid;Methamphetamine;Middle School Student;Modeling;National Institute of Drug Abuse;Opioid;opioid epidemic;Outcome;Participant;Personal Satisfaction;Policy Maker;Population;post intervention;Prevention;Prevention program;prevention service;preventive intervention;Productivity;programs;promote resilience;Public Assistance;Public Health;randomized trial;Randomized, Controlled Trials;Recording of previous events;Records;Research;Resources;Risk;Risk Behaviors;Risk Factors;rural America;rural area;Rural Community;Schools;service utilization;Services;seventh grade;sixth grade;Stream;Students;Subgroup;substance abuse prevention;substance misuse;substance misuse prevention;success;Support System;Surveys;System;Taxes;Testing;Tobacco;Translating;twelfth grade;universal prevention;Variant;Work;Youth

PROJECT_TITLE: Investing in Prevention Infrastructure: Economic Evaluation of the PROSPER System

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Kidney Disease;Lupus;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE The planned multi-site randomized trial aims to proof the superiority of personalized precision dosing of mycophenolate mofetil over current standard of care for the treatment of proliferative lupus nephritis in children. The proposed trial is relevant to public health because, if successful, it promises to improve long- term disease outcomes through rapid control of kidney inflammation, while minimizing unnecessary exposures to immunosuppressive and teratogenic medications.

PI_NAMEs: BRUNNER, HERMINE I (contact);DEVARAJAN, PRASAD

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 8 year old;Achievement;Address;Adherence;Adrenal Cortex Hormones;Adult;arm;Award;base;Biological Assay;Biological Markers;Blood specimen;Body Surface Area;Child;Childhood;Clinical;clinical assay development;clinical care;clinical efficacy;Clinical Trials;clinically relevant;comparative efficacy;Complex;Consensus;Controlled Clinical Trials;conventional dosing;Creatinine;Cyclophosphamide;Data;Development;Devices;Disease;Disease Outcome;Disease remission;dosage;Dose;Double-Blind Method;Drug Kinetics;Drug usage;Eligibility Determination;Enrollment;Erythrocytes;Exposure to;Flare;Fostering;Frequencies;Funding;Gender;Glomerular Filtration Rate;Guidelines;health related quality of life;home test;Immunosuppressive Agents;improved;Individual;Inflammation;Information Dissemination;Intake;Intention;Intervention Studies;Intravenous;Kidney;Kidney Diseases;Knowledge;Legal patent;Lupus;Lupus Nephritis;Measures;meetings;Meta-Analysis;Methodology;Mission;Modification;Monitor;mycophenolate mofetil;Mycophenolic Acid;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neoadjuvant Therapy;nephritis therapy;Newly Diagnosed;novel;Onset of illness;open label;Oral;Organ;Outcome;patient oriented;Patients;pediatric lupus;personalized care;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;primary endpoint;Prognosis;Proteins;Proteinuria;Public Health;Race;Randomized;randomized trial;randomized, clinical trials;Regimen;Research;Research Ethics;Research Personnel;response;Safety;Sampling;secondary endpoint;Site;smartphone application;standard care;standard of care;Standardization;Steroids;Strategic Planning;Technology;Teratogens;Testing;Time;trend;trial planning;United States National Institutes of Health;Urine;Weight;Whole Blood

PROJECT_TITLE: The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Statistical learning and predictive processing are crucial for auditory perception and speech/language development. This project will identify the neural substrates of auditory statistical learning from the level of individual cells, which are within specific cortical laminae, to the level of brain networks across auditory cortical areas in non-human primates. The results of this proposal will enhance our understanding of the cortical bases of learning in normal populations, which, in tum, will provide insights into neurophysiological deficits underlying various clinical conditions in which statistical learning and predictive processes have been shown to be dysfunctional, such as in autism, ADHD, and schizophrenia.

PI_NAMEs: COHEN, YALE E (contact);FISHMAN, YONATAN

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Active Listening;Anterolateral;Area;Attention;Attention deficit hyperactivity disorder;Auditory;Auditory area;auditory pathway;Auditory Perception;auditory stimulus;autism spectrum disorder;base;Behavior;Behavior assessment;Behavioral;Brain;Cells;Clinical;Code;Complex;Cortical Column;Coupled;Cues;Detection;Electrodes;Event;excitatory neuron;expectation;Feedback;Formulation;Frequencies;Goals;Hearing;improved;indexing;Individual;Influentials;information model;information processing;inhibitory neuron;insight;Knowledge;Language Development;Learning;Macaca mulatta;Modeling;Monkeys;neural;neuronal circuitry;Neurons;neurophysiology;nonhuman primate;Pathway interactions;Perception;Phase;Population;predictive signature;Prefrontal Cortex;Primates;Process;Recording of previous events;Research;response;Schizophrenia;Sensory;Speech;statistical learning;Stimulus;Testing;ventral visual stream

PROJECT_TITLE: Hierarchical circuits in the ventral auditory pathway

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;HIV/AIDS;Infectious Diseases;Microbiome;Nutrition;Pediatric;Pediatric - AIDS;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE More than one million children who are HIV-exposed but uninfected are born to pregnant people with HIV every year and have poorer health outcomes than their HIV-unexposed peers, including a >2-fold increased risk of growth stunting and higher risk of infectious morbidity and mortality. The causes of adverse health outcomes in children who are HIV-exposed are poorly understood but may be related to interactions between the gut microbiome and developing immune system. We will compare gut microbiome development in children with and without HIV exposure and growth stunting, define maternal and child antibody response profiles to enteric organisms, and link gut microbiome profiles to immune changes in growth stunted children using a multi’omics approach.

PI_NAMEs: BEBELL, LISA M (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Age;Antibodies;Antibody Response;antibody transfer;antimicrobial;antiretroviral therapy;B-Lymphocyte Subsets;B-Lymphocytes;biobank;Biological;Birth;Blood;Breast Feeding;burden of illness;Caring;Characteristics;Child;Child Health;Childhood;Clinical;cohort;Communicable Diseases;Communication;comorbidity;Data;data pipeline;Defect;Development;Diarrhea;diarrheal disease;Diet;disease model;Early identification;Early Intervention;Enrollment;Enteral;Environmental Exposure;Epidemiology;Fc Receptor;Feces;follow-up;Food;Goals;Growth;gut microbiome;Health;high risk;HIV;Homeostasis;Human Milk;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunology;improved;improved outcome;infant gut microbiome;Infection;Inflammatory;Infrastructure;Innate Immune Response;innovation;Laboratories;Link;Longitudinal cohort;Maternally-Acquired Immunity;Measures;metabolomics;Metadata;Metagenomics;Microbe;microbial;microbiome;microbiome composition;microbiome therapeutics;monocyte;Morbidity - disease rate;mortality;Mothers;Neonatal;Newborn Infant;novel;nutrition;Nutritional status;Organism;Outcome;pathobiont;pathogen;Pathogenicity;Pathway interactions;peer;Persons;Placenta;Plasma;Play;poor health outcome;Predisposition;Pregnancy;pregnant;prospective;Proteobacteria;Public Health;receptor;receptor binding;Recurrence;recurrent infection;Reporting;Research;Research Personnel;Resolution;Risk;Sampling;Serology;Serum;Shapes;Source;species difference;stool sample;System;T-Lymphocyte;Time;Uganda;Umbilical cord structure;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine response;vaccine strategy;Viral;Virulence;Volatile Fatty Acids;Work

PROJECT_TITLE: Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Narrative The CROWN study (Comprehensive Research on Oral and mental health among WomeN) proposes to use interdisciplinary research to better understand the underlying mechanisms and interplay of psychosocial, behavioral, and social structural factors contributing to oral health, mental health, and oral health related quality of life in women with HIV. CROWN will leverage retrospective and prospective data collected in STAR (Study of Treatment and Reproductive outcomes) and the MWCCS (MACS/WIHS Combined Cohort Study) in women living with HIV and at risk of HIV in the US. CROWN will evaluate: 1) the effects of mental health on oral health related quality of life; 2) the effects of mental health on oral health clinical outcomes, and 3) the mediational role of oral health clinical outcomes between mental health and oral health related quality of life.

PI_NAMEs: ALCAIDE, MARIA LUISA;FEASTER, DANIEL J;JONES, DEBORAH LYNNE (contact);PARISH, CARRIGAN L

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Adherence;Affect;Age;Aging;Analysis of Variance;Anxiety;associated symptom;Behavioral;Caring;Clinical;cohort;Cohort Studies;comorbidity;Crowns;Data;data centers;data harmonization;Dental;Dental Care;Dental Hygiene;depressive symptoms;Dimensions;Eating;Enrollment;Evaluation;expectation;follow-up;generalized anxiety;Health;health assessment;health data;health related quality of life;Hemorrhage;High Prevalence;High Risk Woman;HIV;HIV Infections;Hormonal;Hormonal Change;Hormones;Impairment;Individual;Inflammation;Inflammatory Response;Interdisciplinary Study;interest;Interview;life span;Loneliness;longitudinal analysis;Longitudinal cohort;Measures;Mediation;men;Menopause;Mental Depression;Mental Health;Methods;Minority Groups;Modeling;Names;neglect;North Carolina;older women;Oral;Oral health;Outcome;Participant;Pathway interactions;perinatal period;Personal Satisfaction;Persons;PF4 Gene;Pharmaceutical Preparations;Physiological;Play;poor health outcome;Positioning Attribute;Post-Traumatic Stress Disorders;Poverty;Pregnancy;Preventive;prospective;Prospective, cohort study;psychosocial;Puberty;Quality of life;Reporting;reproductive;reproductive outcome;Research;Research Infrastructure;Research Personnel;Risk;Role;Sampling;satisfaction;Self Care;side effect;Site;social health determinants;Social Interaction;social stigma;social structure;structural determinants;Structure;Subgroup;Surveys;symptomatology;Tissues;Tooth Diseases;Tooth Loss;Treatment outcome;Underrepresented Minority;United States;Universities;Visit;Well in self;Woman;Women's Interagency HIV Study;Women's prevalence;Women's study;young woman

PROJECT_TITLE: The CROWN study: Comprehensive Research on Oral and mental health among WomeN


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This research will inform how genetic instructions encoded in the genome are remodeled to generate differences in anatomy within populations and between species. It focuses on two focal traits in fruit flies that involve genes deeply conserved across all animal life, including humans. This work will explain how these genes cooperate with the cellular machinery to produce different traits in animals, and will yield general lessons that are pertinent to human development and disease.

PI_NAMEs: REBEIZ, MARK J (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Animals;Area;behavior influence;Body Patterning;cell behavior;Cell Physiology;Development;Drosophila genus;Drosophila melanogaster;Evolution;fly;Gene Expression Regulation;gene function;gene regulatory network;Genes;Genetic;Genome;Genotype;Homeobox Genes;Human;Human Development;human disease;Individual;Instruction;Life;Maps;Modeling;Molecular;Morphogenesis;Morphology;Mutation;Nature;Organism;Pattern;Phenotype;Pigmentation physiologic function;Population;Process;programs;Research;Research Project Summaries;Shapes;Structure;System;Tissues;trait;transcription factor;Variant;Work

PROJECT_TITLE: The gene regulatory basis of the genotype-phenotype map

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative Our cells need to accomplish mechanical tasks such as segregating chromosomes in a timely manner during cell division. Currently, we do not know how the extensive protein networks needed to accomplish these functions regulate their force production, as many different specialized proteins are involved, and we therefore do not understand the link between the breakdown of these networks in diseases such as cancer. My lab will fill this critical knowledge gap by (1) building essential cytoskeletal networks out of purified components (2) applying advanced biophysical and microscopy techniques to directly measure these tiny forces while also watching how the proteins respond under conditions relevant to both healthy and diseased cells.

PI_NAMEs: FORTH, SCOTT THOMAS (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Adopted;Alzheimer's Disease;Anaphase;Assessment tool;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;Biological Process;biophysical analysis;biophysical properties;biophysical techniques;biophysical tools;Biophysics;Bundling;C-terminal;CDC2 gene;Cell Cycle;Cell division;Cell Physiology;cell type;Cells;Chromosome Positioning;Chromosome Segregation;Chromosomes;Code;Complex;Copy Number Polymorphism;crosslink;Crosslinker;Cyclin B;Cytoskeleton;Data;Defect;diagnostic tool;Disease;Disease Progression;Exhibits;Failure;Fiber;Filament;Fluorescence Microscopy;Friction;Functional disorder;Goals;Human;Image;In Vitro;insight;Kinesin;Kinetochores;Knowledge;laser tweezer;Link;link protein;live cell imaging;Malignant Neoplasms;Measures;mechanical properties;Mechanical Stress;Mechanics;Mediating;Metaphase;Microscopy;Microtubule Bundle;Microtubule-Associated Proteins;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;Motion;Motor;Multiprotein Complexes;mutant;Mutation;Nervous System Disorder;Neurons;novel;optic tweezer;Phase;Phenotype;Phosphorylation;Play;Positioning Attribute;PRC1 Protein;Process;Production;protein complex;Proteins;Publications;Publishing;reconstitution;Regulation;Research;Resistance;Resolution;Role;single molecule;Sister;Slide;Structure;targeted treatment;Techniques;Time;tool;Total Internal Reflection Fluorescent;Viscosity;Work

PROJECT_TITLE: Deciphering the mechanics of microtubule networks in mitosis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Neurosciences;Sleep Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Cardiovascular disease such as vascular atherosclerosis kills more people than any other disease worldwide. Recent work has shown that sleep controls inflammatory pathways leading to cardiovascular disease. Inflammatory cells are produced in the bone marrow by a process called hematopoiesis. In this project, we will investigate how sleep controls hematopoiesis in the bone marrow and inflammation in the vessel wall.

PI_NAMEs: MCALPINE, CAMERON STUART (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Age;age related;aged;Aging;Ally;Apolipoprotein E;Arterial Fatty Streak;ATAC-seq;atherogenesis;Atherosclerosis;Behavior;Biological;biological age;Biological Assay;Blood;Blood Vessels;Bone Marrow;Bone Marrow Cells;calcification;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cell Aging;cell type;Cells;Cessation of life;Clinical;clinical translation;Communication;Confocal Microscopy;Coronary artery;cytokine;Data;Deterioration;Disease;Elderly;Endothelial Cells;Epigenetic Process;epigenetic profiling;Event;Exposure to;Flow Cytometry;Gene Expression Profile;Genetic Transcription;Growth;Growth Factor;Health;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;Human;hypocretin;Image;Immune;Incidence;Individual;Inflammation;Inflammatory;innovation;innovative technologies;Interleukin-6;intravital microscopy;Knowledge;Leukocytes;life span;Link;Macrophage Colony-Stimulating Factor;Mediating;Modeling;Molecular Analysis;monocyte;Monocytosis;mouse model;Mus;Myelogenous;Myocardial Infarction;Neuroimmune;Neuropeptides;neurotransmission;neutrophil;old mice;Osteitis;Pathology;Pathway interactions;Persons;Phenotype;poor sleep;Population;Process;Production;programs;Publishing;receptor;Receptor Cell;Reporting;Resolution;Risk;Role;senescence;sex;Shapes;Signal Transduction;single cell technology;single-cell RNA sequencing;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep regulation;stem cell proliferation;Stromal Cells;Structure;System;systemic inflammatory response;Technology;Testing;Time;transcriptomic profiling;vascular inflammation;Work

PROJECT_TITLE: Influence of sleep on the hematopoietic niche and atherosclerosis during aging

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Hematology;Infectious Diseases;Rare Diseases;Sepsis

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Salmonellae are a leading cause of gastroenteritis and systemic disease worldwide, with widespread multi-drug resistance and a high global burden of morbidity and mortality. This proposal uses identification and mechanistic studies of natural human genetic variation regulating Salmonella invasion, replication, and host cytokine production, along with studies of human populations and mouse models, to improve our understanding of how Salmonella interacts with host cells and how this affects risk of typhoid fever and bacteremia. This study will reveal why certain genetic differences predispose individuals to Salmonella infections and may also reveal new targets for host-directed therapeutic intervention.

PI_NAMEs: KO, DENNIS CHUN-YONE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Alleles;B lymphocyte immortalization;Bacteremia;Cell membrane;Cells;Cessation of life;Cholesterol;Clinical;Communicable Diseases;Cultured Cells;cytokine;Data;Data Set;Disease;Disease susceptibility;Dissection;Divalent Cations;Docking;Enteral;Enterocytes;Epithelial Cells;Functional disorder;Funding;Gastroenteritis;gastrointestinal epithelium;Gene Expression;Genes;Genetic;genetic makeup;genetic variant;Genetic Variation;Genome;genome wide association study;Genotype;Goals;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Histopathology;Human;human disease;Human Genetics;human population study;Immune;Immune response;improved;In Vitro;Inbred Strains Mice;Individual;induced pluripotent stem cell;infected B cell;Infection;Inflammation;Invaded;Knockout Mice;lymphoblastoid cell line;Macrophage;Measures;Mediating;Membrane;metal poisoning;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;Mutation;non-typhoidal Salmonella;novel;novel therapeutic intervention;Nutrient;Oral;oral infection;Outcome;pathogen;Patients;Phenotype;Plasma;Play;polarized cell;Population;Predisposition;Production;Regulation;Resolution;Resources;rho;Risk;Role;Salmonella;Salmonella infections;Salmonella typhimurium;screening;Signal Pathway;System;Systemic disease;Testing;Therapeutic Intervention;trait;Type III Secretion System Pathway;Typhoid Fever;Validation;Variant;Whole Organism

PROJECT_TITLE: HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITY

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Delayed sleep in teens is an intrinsic, biological disruption characterized by being unable to go to sleep early enough and sleeping insufficient amounts; it is pervasive in teens. In addition to daytime fatigue, this loss of sleep is associated with negative behavioral (increased risk taking, depression, agitation, and hyperactivity), cognitive (poor academic performance), medical (increased obesity), and social (increased truancy, increased family tensions, difficulties with socialization) consequences. This project intends to examine a novel therapy for this disruption, one that would require minimal effort and cost to enact and could redefine how this disorder is treated.

PI_NAMEs: ZEITZER, JAMIE M (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: adequate sleep;Adolescence;Adolescent;Agitation;Behavior;Behavior Therapy;Behavioral;Biological;Biological Response Modifier Therapy;circadian;circadian pacemaker;Circadian Rhythms;Clinical Trials;Cognition;Cognitive;cost;Coupling;depressive symptoms;Development;Diabetes Mellitus;direct application;Disease;effective therapy;Enrollment;Event;executive function;experimental study;Exploratory/Developmental Grant;Exposure to;Family;Fatigue;Funding;Future;Healthy People 2020;high school;Home;Hour;Human;Hyperactivity;improved;improvement on sleep;inattention;Individual;Instruction;Jet Lag Syndrome;laboratory experiment;Length;Life;Light;Measurement;Measures;Medical;Melatonin;Mental Depression;Mental Health;Metabolic;millisecond;Moods;National Institute of Child Health and Human Development;novel;novel therapeutics;Obesity;open label;Parents;Participant;Patient Self-Report;Performance;Performance at work;Phase;Phototherapy;Physiological;Placebo Control;Protocols documentation;Puberty;recruit;Regimen;Risk;Risk Taking;Salivary;Schools;Series;shift work;Shift-Work Sleep Disorder;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;social;Socialization;standard care;standard of care;Students;Substance abuse problem;System;Teenagers;Testing;Therapeutic;Time;Travel;Truancy;United States Dept. of Health and Human Services;week trial;Work

PROJECT_TITLE: Passive phototherapy to improve sleep in teens

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative/Relevance to Public Health  Alzheimer’s disease (AD) disproportionately affects Black/African American older adults who have significantly less slow wave sleep (SWS) duration and higher prevalence of vascular risk factors (VRFs), both of which increase Alzheimer’s disease risk, and are associated with AD biomarkers in cognitive normal subjects. More importantly, identifying possible race-related biologic mechanisms driving AD disparities and asymptomatic blacks at higher risk of cognitive decline from AD is crucial to preventing its onset among blacks. The long-term goal of this K23 is for Dr. Bubu to become an independent investigator who identifies pertinent modifiable and possible race-related biologic mechanisms for AD expression e.g. SWS and VRFs, in order to develop strategies for intervention in the hopes to increase sleep quality, and control vascular risk factors as novel therapeutic targets for Alzheimer’s disease prevention in blacks.

PI_NAMEs: BUBU, OMONIGHO A MICHAEL (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Advisory Committees;Affect;African American;African American population;African ancestry;Age;age related;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid deposition;Area;Automobile Driving;Autopsy;Award;Behavior;Biological;Biological Assay;Biological Markers;biomarker identification;Black Populations;Black race;Blood Vessels;cardiovascular risk factor;career development;Characteristics;Clinical;clinical practice;Clinical Research;clinical training;Cognition;Cognitive;cognitive change;cognitive function;cohort;comorbidity;Complement;Couples;Data;Data Analyses;design;Development;Diabetes Mellitus;diagnostic value;Diffusion;disease disparity;Disparity;educational atmosphere;Elderly;Electroencephalography;Excessive Daytime Sleepiness;experience;Fellowship;Foundations;Framingham Heart Study;Funding;Funding Mechanisms;Future;Goals;Grant;Health behavior;Health Disparities Research;High Prevalence;high risk;Hispanic;Home;Hypertension;Image;Immunoprecipitation;Impaired cognition;improved;in vivo;indexing;Individual;innovation;Interdisciplinary Study;Internships;Intervention;Jackson Heart Study;late life;Lesion;Magnetic Resonance Imaging;Manuscripts;Mass Spectrum Analysis;Measures;Mediating;Medical center;medical schools;Mentors;Mentorship;Methods;minimal risk;Minority;molecular marker;multimodality;Nerve Degeneration;Neuroepidemiology;neurofilament protein L;neuroimaging;Neurology;Neuropsychology;Neurosciences Research;new therapeutic target;New York;Not Hispanic or Latino;novel;Obstructive Sleep Apnea;older adult;parent grant;Parents;Participant;Pathologic;Physiological;Physiology;Plasma;Polysomnography;population health;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;prevent;Procedures;professor;programs;prospective;Psychiatry;Public Health;Publishing;Race;racial difference;Recording of previous events;Research;Research Personnel;Research Proposals;Research Training;Resources;Risk;Risk Assessment;Role;screening;Shapes;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Slow-Wave Sleep;tau Proteins;Testing;Training;Underserved Population;unethical;United States National Institutes of Health;uptake;vascular risk factor;white matter;Work;β-amyloid burden

PROJECT_TITLE: The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_NAME: NEW YORK BLOOD CENTER

PHR: Project Narrative The processes controlling blood stem cell regeneration remain poorly understood and appear to change over a person’s lifetime as diseases of the blood are associated with abnormal production as blood stem cells age. Blood cancers are treatable through transplantation of young, healthy blood stem cells but the availability of compatible donors and the inability to expand patient-specific blood stem cells in tissue culture makes blood stem therapy limited. The goal of this research will be to broaden our understand the basic requirements needed for blood stem cells and if low calcium conditions impact stem cell function to aid future attempts to improve the sources of blood stem cell to ultimately increase the availability of healthy blood stem cells available to patients with terminal diseases.

PI_NAMEs: LUCHSINGER, LARRY L (contact)

PROJECT_TERMS: Acceleration;Antioxidants;Apoptotic;BCL2 gene;Biochemical;biological adaptation to stress;Biological Assay;Blood;Blood Cells;Blood coagulation;Blood Platelets;Bone Marrow;Bone Marrow Cells;Ca(2+)-Transporting ATPase;Calcium;cell age;Cell Count;Cell Lineage;Cell Maintenance;Cell membrane;Cell Physiology;cell type;Cells;Characteristics;ChIP-seq;clinical application;clinically relevant;Culture Media;Curiosities;cytokine;Data;Development;Dose;efflux pump;Endoplasmic Reticulum;endoplasmic reticulum stress;Endowment;Engraftment;Environment;Epigenetic Process;Erythrocytes;Exhibits;experimental study;extracellular;Feedback;fluorophore;Formulation;Future;gene function;Genes;Genetic Transcription;Glycolysis;Glycolysis Inhibition;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell expansion;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeostasis;Human;human stem cells;Immune;improved;In Vitro;in vivo;Individual;insight;Intercellular Fluid;ITPR1 gene;Knockout Mice;Leukocytes;life span;Lipids;Literature;Maintenance;Mediating;Methods;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Molecular;Mouse Strains;Mus;novel;Nuclear;Output;Oxidation-Reduction;Pathway interactions;Patients;Persons;Phenotype;Physiological;Population;preservation;prevent;Process;Production;progenitor;programs;Proteins;Publishing;Regulation;Reporter;Reporting;Research;Respiration;response;Role;self-renewal;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Source;stem;stem cell biology;stem cell function;stem cell self renewal;stem cells;stemness;Stress;Terminal Disease;Testing;Therapeutic;tissue culture;transcriptome sequencing;transcriptomics;Translating;translational potential;Transplantation;Umbilical Cord Blood;Up-Regulation

PROJECT_TITLE: Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Impediments to accurate DNA replication by DNA damage and other forms of replicative stress leads to genomic instability and underlies a number of heritable diseases including cancer. This proposal focuses on several pathways that ensure continued replication and suppress mutations by mechanisms that are not well understood. Elucidating the molecular mechanisms of the proteins involved will help to understand how cells maintain genomic integrity and may lead to new therapeutic strategies against replication associated diseases.

PI_NAMEs: EICHMAN, BRANDT F (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Biochemistry;biological adaptation to stress;Biology;biophysical techniques;Bypass;Cell Physiology;Cells;Chemicals;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Maintenance;DNA polymerase alpha-primase;DNA Primers;DNA Replication Damage;DNA replication fork;DNA-protein crosslink;Electron Microscopy;Ensure;Enzymes;experimental study;genome integrity;Genomic Instability;Goals;Heritability;Knowledge;Length;Malignant Neoplasms;Molecular;Molecular Conformation;Multiprotein Complexes;Mutation;novel;novel therapeutic intervention;nuclease;Nucleic Acids;Okazaki fragments;Pathway interactions;Peptide Hydrolases;Polymerase;prevent;Proteins;repaired;replication stress;RNA;Single-Stranded DNA;Site;SMARCA3 gene;SOS Response;Source;Stress;structural biology;Structure;translocase;TRAP Complex;ubiquitin ligase;Visualization;Work

PROJECT_TITLE: Structural Biology of the DNA Replication Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative G protein-coupled receptors (GPCRs), including the β2-adrenoceptor (β2-AR), play critical roles in brain physiology and pathophysiology. We seek to understand how these cascades are regulated at the cellular level. These efforts will provide novel insights into the regulation of neuronal function, and have the potential to enable the development of more efficient therapies for neurological and neuropsychiatric disorders.

PI_NAMEs: TSVETANOVA, NIKOLETA GEORGIEVA (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: A kinase anchoring protein;Address;Adrenergic Receptor;Behavior;Biochemical;Biological Models;Biophysics;Biosensor;Brain;Cell membrane;Cell Nucleus;cell type;Cells;Cellular biology;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupling;Cyclic AMP;Data;Development;Endocytosis;Endosomes;experimental study;Ferritin;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gases;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome-wide;Heterodimerization;Human;Image;improved;Induced pluripotent stem cell derived human neuron;insight;interdisciplinary approach;Learning;Light;Location;Mediating;Mediator;Memory;Memory Disorders;Mental disorders;Methods;Microscopy;Modeling;Molecular;Nervous System Disorder;Neurologic;Neurons;neuropsychiatric disorder;Neurosciences;neurotransmission;novel;Outcome;Output;Pathway interactions;pharmacologic;Pharmacology;phosphoric diester hydrolase;Physiological;Physiology;Play;Positioning Attribute;programs;Property;receptor;Receptor Activation;receptor function;Receptor Inhibition;Receptor Signaling;Regulation;response;ribosome profiling;Role;Shapes;Signal Transduction;Site;Specific qualifier value;Synaptic plasticity;System;Testing;transcriptional reprogramming;transcriptome sequencing;Translational Regulation;Translations;Work

PROJECT_TITLE: Characterization of Compartmentalized GPCR Signaling in Neurons

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR) will provide a rich, dynamic, interactive and supportive environment to train outstanding post-graduate scientists in basic, clinical and translational research that will lead to improved treatment and prevention of HIV/AIDS. This will be accomplished through a collaborative effort between the faculty of the University of Colorado, Colorado State University and the University of Denver. ADEAR will be based at the University of Colorado Anschutz Medical Campus but will take advantage of the diverse research training opportunities available in the affiliated institutions to train the next generation of laboratory and clinical scientists to conduct the research needed to end the AIDS epidemic.

PI_NAMEs: CAMPBELL, THOMAS B. (contact);KVARATSKHELIA, MAMUKA

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN SOCIETY FOR BONE & MINERAL RES

ORG_STATE: DC

PHR: PROJECT NARRATIVE In the US, African Americans (or Blacks), American Indians and Alaska Natives, Latinx, Native Hawaiians, and other Pacific Islanders are underrepresented at all career stages in biomedical and behavioral sciences. The American Society of Bone and Mineral Research (ASBMR) is committed to addressing this issue by offering the Excellence in Scientific Training and Professional Development (EXCEL) program, which will deliver state-of- the-art research techniques and high-quality professional development to early-career scientists/clinicians who identify as an underrepresented minority and who have research interests in fields related to the mission of the ASBMR and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). In addition, this program will educate the broader membership of ASBMR on topics in diversity, equity, and inclusion to render more accepting and supportive work environments by reducing cultural biases within the workplace.

PI_NAMEs: BOUXSEIN, MARY L;HERNANDEZ, CHRISTOPHER JOHN;PRISBY, RHONDA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academia;Address;Aerospace Engineering;African American population;Alaska Native;American;American Indians;Appointment;Awareness;Behavioral Sciences;Biomechanics;Biomedical Engineering;Biomedical Research;Black Populations;bone;Businesses;career;career development;Climate;Clinical;cohort;Collaborations;Communities;Creativeness;Data;design;Development;Disparity;Doctor of Philosophy;Education;Educational workshop;Effectiveness;Endocrinology;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;ethnic diversity;Ethnic Population;experience;Exposure to;Faculty;Financial Support;Fostering;Funding;Future;Goals;Grant;Health;Hispanic Populations;improved;indexing;Individual;innovation;Institution;Instruction;interest;Kinesiology;Latinx;Leadership;leadership development;Mechanics;medical schools;Medical Societies;meetings;member;Mentors;Mentorship;Metabolism;Minerals;Minority Groups;minority scientist;Mission;Molecular Biology;Musculoskeletal;National Institute of Diabetes and Digestive and Kidney Diseases;Native Hawaiian or Other Pacific Islander;Orthopedic Surgery;Participant;peer;peer networks;Peer Review;peer support;Performance;Population;Principal Investigator;Process;professional atmosphere;Professional Organizations;professor;Program Development;programs;Publications;racial diversity;racial population;recruit;Research;Research Personnel;Research Technics;Role;Running;Science;Scientific Societies;Scientist;Series;skill acquisition;skills;Societies;success;supportive environment;Surveys;Talents;Technical Expertise;Texas;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Workplace

PROJECT_TITLE: Enhancing Workforce Diversity in the Bone, Mineral, and Musculoskeletal Field


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health because tumor cell heterogeneity is at the core of therapy resistance and relapse, which remain major clinical challenges underlying poor outcomes for many cancer patients. This project is relevant to the NIH’s mission to seek fundamental knowledge to reduce illness because it will establish technologies for deep profiling of cancer cell clones that are responsible for disease progression. These technologies will be applicable across cancers and have a far-reaching impact.

PI_NAMEs: SANKARAN, VIJAY GANESH;VAN GALEN, PETER  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acute Myelocytic Leukemia;anti-cancer research;Architecture;ATAC-seq;Bar Codes;Biological Assay;Biological Process;Blood Cells;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;Cell division;Cell Lineage;cell type;Cells;Cessation of life;Chromatin;Chronic Lymphocytic Leukemia;Clinical;Clonal Evolution;Clone Cells;cohort;Communities;Complex;Development;Diagnosis;Disease Progression;Dissection;DNA;driver mutation;Ecosystem;Epigenetic Process;epigenome;epigenomics;Evolution;experience;FLT3 gene;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;Genetic Transcription;Goals;Head and Neck Cancer;Heterogeneity;heteroplasmy;Human;improved;in vitro Assay;in vitro Model;Individual;innovation;insight;Knowledge;Lesion;leukemia;Lifting;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Messenger RNA;Methods;Mission;Mitochondrial DNA;Modality;Molecular;mRNA Expression;multiple omics;Mutate;Mutation Analysis;Myeloproliferative disease;neoplastic cell;novel therapeutic intervention;Nuclear;Outcome;Output;Patients;Pattern;Performance;Population;Positioning Attribute;Procedures;Production;programs;Public Health;Recurrence;Recurrent disease;Relapse;Research;Research Personnel;Resistance;Resolution;Sampling;Shapes;single cell analysis;single cell ATAC-seq;single cell sequencing;Solid Neoplasm;Structure;System;Technology;therapy resistant;tool;transcriptome;transcriptome sequencing;tumor;Tumor Biology;tumor eradication;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Clonal analysis of cancer by mitochondrial DNA barcoding


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Osteoarthritis

PHR: NARRATIVE  This proposal will develop a rapid multi-relaxation imaging technique that can provide simultaneous three- dimensional T1, T2, and T1ρ relaxation mapping for quantifying tissue composition and ultra-structure using magnetic resonance imaging. The imaging technique incorporates a novel multi-relaxation mapping sequence using 3D golden-angle rapid acquisition and a novel physics-informed deep learning reconstruction and will be evaluated in a knee disease model. Our novel proposal would provide a new rapid imaging approach to non- invasively monitor disease-related and treatment-related changes in tissue composition and ultra-structure through multi-relaxation assessment and will have broad clinical applications for various diseases.

PI_NAMEs: LIU, FANG  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Biochemical;Cartilage;cartilage degradation;Clinical;clinical application;Clinical Research;clinical translation;Collagen;Collagen Fiber;Complex;cost;deep learning;Degenerative polyarthritis;Disease;disease model;Extracellular Matrix;Face;Histologic;Human;human tissue;Image;image reconstruction;imaging approach;imaging biomarker;imaging capabilities;Imaging Techniques;Joints;Knee;Knee Osteoarthritis;macromolecule;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;mechanical properties;Methods;millimeter;Noise;non-invasive imaging;non-invasive monitor;novel;Patients;Physics;Proteoglycan;reconstruction;Relaxation;Reporting;research study;Resolution;Role;Rotation;Scanning;self supervised learning;Signal Transduction;Slice;Staging;Structure;Techniques;Thick;Three-Dimensional Imaging;Time;Tissue Model;Tissues

PROJECT_TITLE: Rapid Three-dimensional Simultaneous Knee Multi-Relaxation Mapping

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]