ADMINISTERING_IC: TS

IC_NAME: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

ORG_CITY: WATERTOWN

ORG_NAME: ALS THERAPY DEVELOPMENT FOUNDATION

PHR: Project Narrative This project takes advantage of an existing and growing ALS Natural History Study dataset from the ALS Therapy Development Institute’s (ALS TDI) Precision Medicine Program (PMP). The PMP has been operating since 2014 and has enrolled more than 800 people with ALS during that time. This funding opportunity designed to support investigator initiated research that will identify and evaluate risk factors contributing to ALS provides and excellent opportunity to fund a collaborative research effort assessing the data collected over the past 8 years under the auspices of the IRB approved PMP. Specifically, Funding Option is intended to support ALS risk factor research investigations on environmental, genetic, or other ALS risk factors using our existing, well substantiated evidence base that would benefit greatly from strengthened rigorous evaluation. This proposal brings together ALS researchers from the ALS Therapy Development Institute and Johns Hopkins University to evaluate the existing dataset, clean and quality control the dataset, format and standardize data according to best practices, then assess existing purported ALS risk factors within the dataset, and subsequently assess new possible risk factors. This project has also recruited the ALS Geospatial Hub team, a group of geographical information experts, led by a person with ALS, Pat Dolan, to assess United States- based geographical risk factors. Finally, the project will support the implementation of a web- based portal that will allow external researchers to evaluate data from the PMP to formulate or test new ALS risk-factor or biological hypotheses.

PI_NAMEs: VIEIRA, FERNANDO GAMEIRO (contact)

PROJECT_TITLE: RFA-TS-23-001: Assessment of ALS Risk Factors from ALS TDI's Ongoing Natural History Study (n = 784)


ADMINISTERING_IC: GH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Center for Global Health

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: LONDON SCH/HYGIENE & TROPICAL MEDICINE

ORG_ZIPCODE: WC1E 7HT

PHR: Project narrative We propose a five-year programme of capacity strengthening and research to (i) strengthen country-based capacity for timely, agile public health research in four countries affected by large protracted crises; (ii) explore novel cross-cutting methods including community-led mortality and epidemic surveillance, and data science applications; and (iii) generate key evidence on different thematic areas including mortality, transmission of SARS-CoV-2 and other epidemic threats, improved hygiene behaviour measures and interventions, measurement of the indirect impacts of the pandemic on sexual and reproductive health among young and adolescent girls, and quantification of impacts on non-communicable diseases and mental health, with evaluation of novel care models for these health problems.

PI_NAMEs: CHECCHI, FRANCESCO  (contact)

PROJECT_TITLE: GH21-004, COVID-19 and related public health threats in populations affected by crises: a multi-disciplinary, collaborative research programme


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Military sexual trauma (MST) is a common duty-related stressor which occurs among one in four female Veterans and is associated with substantial concerns about social isolation and high rates of PTSD. Women with MST also experience numerous person-level barriers to care including the desire to avoid male-dominated VA clinics, transportation difficulties and childcare responsibilities. Treatment programs that address the social and mental health needs of this population and acknowledge barriers to care that disproportionately affect women are lacking. The proposed study will use a hybrid effectiveness-implementation design to evaluate the in-home delivery of a gender-sensitive, evidence-based coping skills program to improve social and role functioning as well as reduce PTSD and will prioritize enrolling rural women in a representative manner. If the program is found to be successful at improving social functioning and PTSD, and in reducing barriers to care, it will provide a tremendous benefit to women Veterans with MST, particularly those in rural areas.

PI_NAMEs: CLOITRE, MARYLENE  (contact)

PROJECT_TERMS: active comparator;Address;Administrator;Affective;Aftercare;barrier to care;Caring;Child Care;Clinic;Clinical effectiveness;Clinical Trials;Communities;community engagement;Consolidated Framework for Implementation Research;Coping Skills;Data;Dedications;Diagnosis;Diagnostic;Disproportionately impacts women;DSM-V;Effectiveness;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;Enrollment;Ensure;Epidemic;Evaluation;evidence base;experience;Face;Family;Female;follow-up;Functional impairment;Future;future implementation;Gender;Geography;Health Services Accessibility;Healthcare;Home;Hybrids;Impairment;improved;Intervention;male;medical specialties;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;military veteran;Occupations;Outcome;Participant;patient oriented;Patients;Perception;Persons;Population;Post-Traumatic Stress Disorders;preference;primary outcome;Process;process evaluation;Program Development;programs;Psychological reinforcement;Psychotherapy;Randomized;Randomized, Controlled Trials;recruit;Regulation;remote delivery;Replicating Effective Programs;Reporting;Research;Research Design;Resources;response;Risk;Role;Rural;rural area;Rural Health;rurality;Sampling;satisfaction;secondary outcome;service delivery;Services;Severities;sexual trauma;Site;skills training;social;social engagement;Social Functioning;Social isolation;social skills;Social support;Stratification;stressor;surveillance data;Symptoms;Technology;Teleconferences;Time;Training Programs;Transportation;treatment program;Underserved Population;Unemployment;Variant;Veterans;Woman;Work

PROJECT_TITLE: Connecting Women to Care: Home-based Psychotherapy for Women with MST Living in Rural Areas

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: TBI is often a chronic disorder afflicting many Veterans and is associated with sleep-wake abnormalities and daytime cognitive and behavioral problems. Humans with TBI and rodent models of TBI demonstrate many sleep problems including problems in falling asleep, frequent awakenings, less total sleep, and resultant daytime problems with memory loss and anxiety. We have developed a mouse model of chronic TBI that identifies sleep-wake disturbances by electroencephalogram (EEG). One brain mechanism for these sleep- wake problems in TBI involves the neuropeptide orexin (ORX). We propose to test the treatment effects of an ORX receptor antagonist medication in male and female mice with chronic TBI. This medication, lemborexant, may reverse sleep EEG changes and restore sleep and behavioral functions. Relevance to Veterans Health: Many Veterans with chronic TBI have sleep problems, greater morbidity and poorer quality of life. This pilot proposal can ultimately lead ultimately to trials of these commercially available treatments in Veterans.

PI_NAMEs: ZIELINSKI, MARK ROBERT (contact)

PROJECT_TERMS: Affect;Afghanistan;Animal Model;Animals;antagonist;Anxiety;Area;Arousal;awake;Behavior;behavior test;Behavioral;behavioral impairment;behavioral response;Brain;Brain Injuries;C57BL/6 Mouse;Cells;Cerebrospinal Fluid;cholinergic;Chronic;Chronic Disease;Cognition;Cognitive;comparison control;conditioned fear;Cues;dopaminergic neuron;Dose;Electroencephalography;Emotional Disturbance;Environment;experience;experimental group;falls;Female;Fright;Funding;Grant;Health;Human;human model;hypocretin;Hypothalamic structure;Impaired cognition;improved;improvement on sleep;Individual;Injury;Iraq;Knowledge;Lead;Lesion;Light;Maintenance;male;Measures;Mediating;Memory;Memory impairment;Memory Loss;Modeling;Morbidity - disease rate;motor behavior;mouse model;Mus;neural;neural circuit;Neurons;neuropeptide B;Neuropeptides;Neurophysiology - biologic function;non rapid eye movement;noradrenergic;novel;orexin A;orexin B;Outcome;Pathway interactions;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;Primary Insomnia;Problem behavior;Quality of life;receptor;rehabilitation research;REM Sleep;Reporting;Research;Research Methodology;Research Personnel;research study;Rewards;Rodent;Rodent Model;Services;Sleep;sleep abnormalities;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep onset;Sleeplessness;symptomatology;Symptoms;System;TBI Patients;Testing;Time;translational impact;treatment effect;Veterans;War;wound

PROJECT_TITLE: Treatment of Sleep Disturbances in TBI with Orexin Receptor Antagonist

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of this project is to understand mechanisms that drive infant leukemogenesis. I have identified Skida1 as a key target of MLL-ENL, a common pediatric acute myeloid leukemia (AML) mutation. The aims of my proposal will test whether Skida1 promotes pediatric AML and whether it offers a potential target for therapy.

PI_NAMEs: MENDOZA-CASTREJON, JONNY  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;adult leukemia;adult stem cell;Age;age related;Alleles;Binding;Biological Assay;Blood Cells;Cell Line;Cells;cellular transduction;Childhood;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Chimeric Proteins;ChIP-seq;Chromatin;Chromosomal translocation;Co-Immunoprecipitations;Collecting Cell;conditional knockout;Data;Dependence;Development;Doxycycline;driver mutation;Embryo;Enhancers;experimental study;Frequencies;Gene Expression;Genes;Genetic Enhancer Element;Genetic study;Genetic Transcription;Genome;Germ Lines;Goals;Hematopoiesis;Hematopoietic stem cells;Hematopoietic System;Human;Infant;Infant Leukemia;innovation;Knockout Mice;leukemia;Leukemic Hematopoietic Stem Cell;leukemogenesis;Life;Link;loss of function;LoxP-flanked allele;Maintenance;Maps;Mixed-Lineage Leukemia;MLL gene;MLL-AF9;Monitor;mouse genetics;mouse model;Mus;Mutation;Neonatal;Neonatal Leukemia;neonate;novel;novel therapeutics;Pattern;postnatal;Preleukemia;progenitor;programs;promoter;response;Retroviridae;Role;self-renewal;single-cell RNA sequencing;targeted treatment;Testing;transcriptome;transcriptome sequencing;Transplantation;Work

PROJECT_TITLE: The Role of SKIDA1 in Acute Myeloid Leukemia Initiation and Maintenance


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pancreatic cancer risk factors, including pancreatitis and obesogenic high-fat diet, conspire with mutant KRAS to promote PDAC with high penetrance; however, the underlying mechanism remains elusive. The objective of this proposal is to determine if NADPH oxidase is a critical mediator in this context. For this purpose, we will employ novel genetically engineered mouse models expressing pancreatic acinar cell-specific endogenous levels of KRASG12D with or without a critical component of the NADPH oxidase docking subunit p22phhox in the context of these risk factors. Successful completion of this project will provide new insights into preventive and therapeutic strategies against this extraordinarily lethal disease in humans.

PI_NAMEs: LU, WEIQIN  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Ablation;Acinar Cell;Adult;Cancer Etiology;cancer prevention;cancer therapy;Cessation of life;Chronic;Consumption;Data;design;Development;dietary;Disease;Docking;Enzymes;Event;Exposure to;Generations;Genetic;Genetically Engineered Mouse;High Fat Diet;Human;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;insight;Knowledge;KRASG12D;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Modification;Molecular;Mouse Strains;Mus;mutant;Mutation;NADPH Oxidase;novel;Obesity;obesogenic;Oncogenes;Oncogenic;Oranges;Outcome;Oxidation-Reduction;Oxidative Stress;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pancreatitis;Pathologic;Penetrance;Prevention;Preventive;Reactive Oxygen Species;Reporting;Risk Factors;Stimulus;systemic inflammatory response;Testing;Therapeutic;TP53 gene;tumor progression;United States

PROJECT_TITLE: Targeting NADPH Oxidase for Pancreatic Cancer Prevention and Therapy

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Genome instability due to accumulation of gross chromosomal rearrangements (GCRs) is a characteristic of many types of inherited and sporadic cancers and acquisition of genome instability is thought to drive the development of these cancers. This project will identify the genes and pathways that suppress genome instability, elucidate the mechanisms that normally suppress accumulation of GCRs and develop assays for GCRs for use in human cells. The resulting insights will facilitate understanding the basis for genome instability in cancer and ultimately lead to improved cancer diagnostics and therapeutics that target genome instability.

PI_NAMEs: KOLODNER, RICHARD D (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Ablation;Address;Alleles;assay development;Back;base;Biological Assay;Biological Models;BRCA1 gene;BRCA2 gene;Cancer cell line;Cancer Diagnostics;cancer therapy;Cell Survival;Cells;Characteristics;Chromosomal Rearrangement;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;cohesion;Complex;condensin;Data;Defect;detection assay;Development;DNA;DNA metabolism;DNA Repair;DNA sequencing;Excision;EXO1 gene;experimental study;feature selection;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Recombination;Genetic study;Genetic Variation;Genome;genome sequencing;Genomic approach;Genomic Instability;Genomics;Goals;Health;Homologous Gene;Human;Human Genome;improved;Individual;Inherited;insight;interest;Invaded;Joints;Kinetics;Malignant Neoplasms;Mediating;Metabolic;Molecular;Monitor;Mutate;Mutation;novel;Pathway interactions;personalized approach;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Predisposition;prevent;Process;Proteins;Recurrence;Research;Saccharomyces cerevisiae;Series;Single-Stranded DNA;Site;Syndrome;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;therapeutic target;tool;tumor progression;Tumor Suppressor Proteins;whole genome;Work

PROJECT_TITLE: Enzymatic Mechanisms of Genetic Recombination

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Evolution is central to many public health challenges, from the development of cancer to immune evasion and drug resistance in infectious pathogens. Robust methods are needed to translate genetic data into actionable information that can be used to improve treatment. This project will develop new computational methods to quantitatively assess complex evolutionary processes, with applications that will improve our understanding of host-pathogen coevolution and the interpretation of high-throughput mutagenesis studies to characterize the relationship between genotype and phenotype.

PI_NAMEs: BARTON, JOHN P (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Accounting;adaptive immune response;Bacterial Antibiotic Resistance;Biological Assay;Communities;Complex;Computer software;Computing Methodologies;Data;Development;driver mutation;Drug resistance;Evolution;fitness;Genetic;Genetic Epistasis;genetic linkage;Genotype;Goals;Growth;HIV-1;host-pathogen coevolution;Human;Immune Evasion;Immune response;Immunotherapeutic agent;improved;Malignant Neoplasms;Methods;Mutagenesis;Mutation;novel strategies;pathogen;Phenotype;Physics;Population;Process;programs;protein function;Public Health;Research;Role;Science;Statistical Methods;Techniques;Time;tool;Translating

PROJECT_TITLE: Methods for quantifying selection in evolving populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Neurosciences

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: 8. Project Narrative The organophosphate (OP) insecticide phorate must be bioactivated to an active metabolite(s) and thus it takes several hours to display toxic signs. Some of our novel oximes have appreciably longer half-lives (several hours) than 2-PAM (about an hour) and they also can reactivate OP-inhibited plasma butyrylcholinesterase, potentially converting it to a pseudo-catalytic scavenger. In this project we expect our oximes to provide greater survival efficacy of lethal doses of phorate than 2-PAM because of their longer plasma presence and their prolonged conversion of plasma butyrylcholinesterase into a pseudo-catalytic detoxication mechanism.

PI_NAMEs: MEEK, EDWARD C (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acetylcholinesterase;Acute;antagonist;Antidotes;Aryl Hydrocarbon Hydroxylases;Atropine;Attenuated;attenuation;Behavior;Behavioral;bioscavenger;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain Injuries;Bronchoconstriction;Butyrylcholinesterase;Central Nervous System;Cessation of life;Chemicals;cholinergic;Cholinesterase Inhibitors;Circulation;Cytochrome P450;Data;Data Set;detoxication;dosage;Dose;enzyme activity;Female;Flavins;Goals;Half-Life;Hour;Human;improved;In Vitro;in vivo;inhibitor;Insecticides;invention;Laboratories;Lead;Legal patent;Libraries;Life;Literature;male;Mediating;Metabolism;Mixed Function Oxygenases;Modeling;Muscarinic Acetylcholine Receptor;nerve agent;Neurons;neuropathology;novel;organophosphate poisoning;Organophosphates;Oximes;Paraoxon;Parathion;Parents;Pattern;Peripheral;Peripheral Nervous System;Phorate;Plasma;Poisoning;Population;prevent;Rattus;Regimen;Reporting;respiratory;Respiratory Failure;Respiratory Muscles;saliva secretion;Sarin;Seizures;Series;Serum;sex;Sex Differences;Spasm;Survivors;Testing;Therapeutic;therapeutically effective;Time;Toxic effect;toxic organophosphate insecticide exposure;Toxicity Attenuation;Tremor;Violence

PROJECT_TITLE: Novel oxime antidotes for an organophosphate insecticide requiring bioactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Small vessel cerebrovascular disease is common in the elderly, and is a well-known contributor to cognitive decline. A major gap in the field, however, is the ongoing need for reliable and reproducible biologic markers of vascular disease suitable for early detection, disease monitoring, and measuring treatment efficacy. The overarching goal of this proposal is to clinically validate novel neuroimaging and fluid-based biomarkers of cerebrovascular disease selected by the NINDs and developed during the first five years of the MarkVCID consortium.

PI_NAMEs: KRAMER, JOEL H (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Behavioral;Biological;Biological Markers;Biological Models;biomarker development;Blood Vessels;California;Censuses;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Clinical;clinical phenotype;Clinical Sciences;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive function;cohort;Collaborations;COVID-19;Data;Dementia;Development;Diagnosis;Diffusion;Disease;Disease Pathway;Early Diagnosis;Early identification;Elderly;Endothelium;Endowment;Enrollment;exosome;experience;follow-up;Foundations;functional decline;Functional disorder;Goals;Head;Image;image processing;Impaired cognition;improved;Individual;Infrastructure;Injury;innovation;Ischemia;Laboratories;Lead;Leadership;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measures;member;mild cognitive impairment;Modeling;Molecular;Monitor;Multi-site clinical study;National Institute of Neurological Disorders and Stroke;neuroimaging;Neurology;Neuropsychology;novel;Outcome;outcome prediction;Pathology;Pathway interactions;Patients;personalized medicine;Persons;Phase;Phenotype;Plasma;Population Heterogeneity;precision medicine;Productivity;professor;Prognosis;Protocols documentation;Psychometrics;Public Health;recruit;Reproducibility;Research;Sampling;Scientist;Signal Transduction;Site;Specific qualifier value;Statistical Models;Techniques;Testing;tool;Treatment Efficacy;Universities;Validation;validation studies;vascular cognitive impairment and dementia;Vascular Diseases;white matter;Work

PROJECT_TITLE: Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Pediatric;Pediatric Cancer;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The ETV6/RUNX1 pre-leukemic clone is initiated in utero in some infants who go on to develop pediatric acute lymphoblastic leukemia, as well as a portion of healthy infants who do not develop cancer. We will determine the strength of association between birth with the ETV6/RUNX1 translocation and childhood leukemia risk and we will establish predictors of initiation and persistence of the ETV6/RUNX1 pre-leukemic clone into early childhood. This project will increase our understanding of childhood leukemia etiology and allow for the development of risk prediction studies.

PI_NAMEs: MARCOTTE, ERIN  (contact);NELSON, HEATHER HAMMOND

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Acute Lymphocytic Leukemia;Age;Appearance;Birth;Blood;Blood Cells;Blood specimen;California;cancer diagnosis;case control;Case/Control Studies;Cells;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Clinical;clinical application;cohort;Cohort Studies;Data;Descriptive Epidemiology;design;detection method;Development;digital;Disease;Dryness;early childhood;Epidemiology;epidemiology study;ethnic diversity;Ethnic Population;Etiology;Event;Fostering;Gene Fusion;Genetic;Genetic Diseases;genetic risk assessment;Genomics;Goals;high risk;high risk population;in utero;Individual;Infant;innovation;Investments;Knowledge;Laboratories;leukemia;Longitudinal Studies;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Michigan;Monitor;Neonatal Screening;New Hampshire;Newborn Infant;novel;Participant;Patients;Pediatric epidemiology;Population;population based;Predictive Factor;Preleukemia;prenatal;Prevalence;Prevention;racial population;Recontacts;Risk;Risk Estimate;Risk Factors;risk prediction;RNA;RNA-Directed DNA Polymerase;RUNX1 gene;screening;Spottings;t(12;21)(p13;q22);Time;Translating;United States National Institutes of Health;Work

PROJECT_TITLE: Prevalence and persistence of the ETV6/RUNX1 pre-leukemic clone

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: DAR ES SALAAM

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS

PHR: PROJECT NARRATIVE SPARCO-Tanzania will contribute data on sickle cell disease (SCD) in Tanzania into the SCD in Sub-Saharan Africa Network database, advance SCD standards of care, enhance the skills in clinical care and research on SCD and generate data on the current status of SCD and effectiveness of interventions that will inform policy change. These activities will lead to an increased understanding of the disease in Africa and improve the effectiveness of care and treatment programs, leading to the reduction in the morbidity and mortality due to SCD in Sub-Saharan Africa.

PI_NAMEs: BALANDYA, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Address;Adoption;Advocacy;Affect;Africa;Africa South of the Sahara;African;age related;American Society of Hematology;APOL1 gene;Area;authority;big data management;Birth;Caring;Cells;Clinic;Clinical;clinical care;Clinical Management;Clinical Research;cohort;Cohort Studies;Collaborations;Collection;Communication;Comprehensive Health Care;Consent;Country;Creatinine;Data;Data Analyses;Data Coordinating Center;data infrastructure;Databases;design;Development;Disease;Disease Management;District Hospitals;Doctor of Philosophy;Educational process of instructing;effective intervention;Effectiveness;Effectiveness of Interventions;electronic data;Elements;Enrollment;Essential Drugs;Event;evidence base;experience;Failure;Fellowship;Fellowship Program;Fetal Hemoglobin;Fetal Kidney;follow-up;Funding;Genetic;genetic variant;Ghana;Goals;Grant;Growth;Guidelines;Haplotypes;Health;Health Personnel;Health system;health training;Healthcare;Hematology;HIV/TB;Home;Hospital Information Systems;Hospitals;Human Resources;hydroxyurea;immune activation;Immunization;implementation research;improved;Individual;Infection;International;Intervention;Investigation;kidney dysfunction;Laboratories;Link;Malaria;meetings;member;Mendelian disorder;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neonatal Screening;Newborn Infant;Nigeria;Ontology;operation;Organ;Patient Education;Patients;Phenotype;Policies;Postdoctoral Fellow;preventive intervention;programs;Prophylactic treatment;Proteins;Pyrimethamine;Readiness;Recommendation;Reporting;Research;Research Personnel;Research Training;Risk;scale up;screening;screening program;Serum;shared database;Sickle Cell Anemia;sickling;Site;skills;Societies;standard of care;Structure;Students;success;Tanzania;tertiary care;Therapeutic Intervention;Training;Training Programs;Translations;treatment program;United States National Institutes of Health;Urine;Variant;Visit;Work;Zanzibar

PROJECT_TITLE: Sickle Pan-African Research Consortium (SPARCO)- Tanzania


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Wound Healing and Care

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Pemphigus vulgaris (PV) is a life-threatening autoimmune disease that causes severe blistering on the skin and mucous membranes, with no available cure. The present application explores the development of immunotherapeutics to precisely target and deplete anti-desmoglein-3 (Dsg3) autoreactive B cells without impacting normal B cells; Dsg3 is the main autoantigen in the mucosal-dominant type of the disease. The developed method of targeting antigen-specific autoreactive B cells provides a platform for future therapeutics for antigen-specific autoimmune diseases.

PI_NAMEs: RASHIDIAN, MOHAMMAD  (contact);WEI, ERIN

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adhesions;Adult;Affect;Affinity;Agammaglobulinaemia tyrosine kinase;Animal Model;Animals;antagonist;Antibodies;Antigen Targeting;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autologous;autoreactive B cell;autoreactivity;B-Cell Antigen Receptor;B-Lymphocytes;Basement membrane;Binding;Biological Products;Bioluminescence;Bulla;Bypass;CD3 Antigens;Cell Adhesion Molecules;cell type;Cell-Mediated Cytolysis;Cells;Chimeric Proteins;Clinic;Clinical;cost;Data;desmoglein III;Desmosomes;Development;Disease;disease model;efficacy evaluation;efficacy testing;Engineering;Enzyme-Linked Immunosorbent Assay;Epidermis;Evaluation;extracellular;Fc domain;Flow Cytometry;Future;Goals;Human;IgG1;Immune system;Immunofluorescence Immunologic;Immunological Models;Immunosuppression;Immunosuppressive Agents;Immunotherapeutic agent;In Vitro;in vivo;infection risk;keratinocyte;Life;Mediating;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Natural Killer Cells;neonatal Fc receptor;novel;Outcome;Pain;Pathogenicity;Patients;Pemphigus;Pemphigus Vulgaris;Peripheral Blood Mononuclear Cell;personalized medicine;Phagocytes;Pharmaceutical Preparations;Phase;pre-clinical;Principal Investigator;Production;Protein Engineering;Proteins;prototype;recruit;Regulatory T-Lymphocyte;Relapse;Resources;response;rituximab;Role;Serum;side effect;Skin;Specificity;standard care;standard of care;Steroids;Surface Plasmon Resonance;T-Cell Receptor;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;tool;tositumomab;Translating;Treatment Efficacy;treatment strategy;Tyrosine Kinase Inhibitor;Vaccines;Writing

PROJECT_TITLE: Developing non-immunosuppressive immune-based therapeutics for targeted treatment of autoimmune diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The proposed program provides postdoctoral research training in medical genetics with an overall goal to train future academic leaders who will apply this knowledge to an understanding of human genetic disorders. Through rigorous training in the principles of genetics, trainees will exploit recent advances in genetics and genomics to discover the pathogenesis and pathobiology of inherited disease, and to use this information to improve human health. Understanding the etiology of heritable disease will lead to molecular classification, inform risk of recurrence, facilitate development of novel and more effective therapies to reduce illness and disability, and has potential to reduce costs in healthcare through stratification of patients for treatment and management based on the underlying genetic basis of their conditions.

PI_NAMEs: MORTON, CYNTHIA CASSON (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;Grant;Training

PROJECT_TITLE: Training Grant in Genetics


FUNDING_MECHANISM: OTHERS

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: The 2018 MISSION Act may increase Veterans’ access to healthcare outside of VHA. However, mental health provider shortages in rural communities affect availability of psychological services in these areas. MISSION Act presents a distinct opportunity for VHA to draw upon its relationships with community stakeholders to develop innovative methods to improve access to mental healthcare for rural Veterans. This CDA will engage key stakeholders (e.g., Veterans, MISSION Act providers) to understand the current state of mental health treatment delivered through MISSION Act and develop a program that enhances the ability of community providers to serve rural Veterans. The proposed research will initially focus on rural Veterans with military sexual trauma – a high priority, understudied rural Veteran group. Broad implications of this work include advancements in VHA community care that increase delivery of high-quality healthcare to rural Veterans.

PI_NAMEs: BOYKIN, DERRECKA M (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Affect;Appointment;Area;Award;Caring;Characteristics;Clinic;clinical practice;Cognitive;Communities;Communities That Care;community based participatory research;community building;community engaged approach;community engaged research;community engagement;Community Health;Community Healthcare;Community Networks;community planning;Consultations;County;Cultural Backgrounds;Data;Data Analyses;design;Development;Distal;Distress;Doctor of Philosophy;Educational workshop;Evaluation;evidence base;experience;Female;Funding;Future;gaps in access;Goals;Grant;health care availability;health care quality;health care settings;Health Personnel;Health Services Accessibility;Health Services Administration;Health Services Research;Healthcare;Homogeneously Staining Region;Improve Access;improved;innovation;Institution;Interview;Knowledge;Length;male;medical specialties;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental state;Mentorship;method development;Methods;Military Personnel;military veteran;Mission;Modeling;novel;Outcome;Patient-Focused Outcomes;Patients;Post-Traumatic Stress Disorders;Program Development;programs;Provider;psychologic;Psychotherapy;Qualitative Methods;Quality of Care;Recording of previous events;recruit;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resources;Review Literature;Rural;Rural Community;rural counties;Rural Health;rural healthcare;satisfaction;secondary analysis;Self Efficacy;Services;sexual trauma;Structure;suicidal risk;Surveys;Survivors;symposium;Testing;Texas;Training;Training Activity;trauma exposure;Trust;underserved community;Variant;Veterans;Veterans Health Administration;Wait Time;Woman;Work

PROJECT_TITLE: Understanding Community-based Mental Healthcare for Rural Veterans with Military Sexual Trauma

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE  Continuous and atomistic descriptions of enzyme mechanisms are crucial to the characterization of protein function and dysfunction—a common cause of disease—but unattainable with current techniques, necessitating novel methods which leverage computational-experimental synergy. The proposed work will investigate improvement of experimental data gathering and deconvolution through computational simulation and modeling as well as improve available tools for molecular dynamics simulations of biochemical events. The resulting methods will produce a more ideal, continuous picture of atomistic protein dynamics, bettering the ability of researchers to probe and describe the biophysical phenomena which often underly disease.

PI_NAMEs: FARRUGIA, MIKAELA  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Acceleration;Benchmarking;Biochemical;Biological Models;Biology;Biophysics;Computational Technique;Computer Models;Computer Simulation;computer studies;Computing Methodologies;cost;Crystallography;Data;design;Development;Disease;electron density;empowerment;enzyme mechanism;Event;experimental study;falls;follow-up;Functional disorder;Generations;Genetic;Goals;Health;high dimensionality;Hybrids;improved;Individual;insight;Investigation;Methodology;Methods;Modeling;Molecular Conformation;molecular dynamics;molecular mechanics;Molecular Structure;novel;particle;Pathway interactions;predictive modeling;Process;protein complex;Protein Dynamics;protein function;Proteins;quantum;Reaction;Research;Research Personnel;Role;Sampling;simulation;Structure;Swarm intelligence;synergism;Techniques;Time;tool;Universities;Validation;Weight;Work;X-Ray Crystallography

PROJECT_TITLE: Development & application of computational methods for the study of protein dynamics with PmHMGR as a model system


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Alternative lengthening of telomeres (ALT) is a non-telomerase dependent pathway responsible for 15% of all cancers. Recent studies identified Telomeric repeat-containing RNA (TERRA), a transcript of telomere as a hallmark of ALT. This proposal aims to elucidate the molecular mechanisms underlying TERRA mediated activity and cellular function, which could help to pave a new path for treatment of ALT based cancers.

PI_NAMEs: WONDIMAGEGNHU, BERSABEL  (contact)

PROJECT_TERMS: alternative treatment;Apoptosis;Binding;Biochemical;Biological;Biological Assay;cancer cell;Cell Aging;Cell Physiology;Cells;Cellular biology;Chromosomes;Complex;Detection;DNA;DNA-Directed RNA Polymerase;Elongation by Telomerase;Exhibits;experience;G-Quartets;Genetic Transcription;helicase;Heterogeneity;homologous recombination;Hybrids;Individual;insight;Invaded;Kinetics;Length;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Microscope;Modeling;Molecular;Molecular Conformation;Movement;Nucleoproteins;overexpression;oxidative damage;Pancreatic ribonuclease;Pathway interactions;prediction algorithm;protein complex;Proteins;Protocols documentation;Rad51 recombinase;recruit;Regulation;ribonuclease H1;Ribonucleases;RNA;RNA annealing;RNA Binding;RNA Sequences;Role;single molecule;single-molecule FRET;Sister Chromatid;Somatic Cell;Structure;System;Tandem Repeat Sequences;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Pathway;Transcript;ultra high resolution;Untranslated RNA;Up-Regulation;Visualization

PROJECT_TITLE: Studying the role of TERRA in telomere protection and length regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Relevance How force regulates pluripotent stem cell differentiation and cell fate at the level of chromatin remains largely elusive. We plan to determine and elucidate if and how chromatin deformation regulates pluripotent stem cell differentiation in this project and determine the fundamental differences between normal stem cells and cancer stem cells. The long-term goal is to develop novel approaches and strategies to intervene pathological processes like malignant tumors.

PI_NAMEs: WANG, NING  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Actins;Adult;Biomedical Engineering;Calcium Signaling;cancer initiation;cancer stem cell;Cardiovascular Diseases;CAV1 gene;Cell Differentiation process;Cell Nucleus;Cell surface;Cells;Chemicals;Chinese Hamster Ovary Cell;Chromatin;Chromatin Structure Alteration;Complex;Cytoplasm;Cytoskeleton;Data;demethylation;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;Embryonic Development;Embryonic Induction;embryonic stem cell;Exhibits;Experimental Designs;Fibrosis;Focal Adhesions;Frequencies;Gene Activation;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic Transcription;Genomic Instability;Goals;Heterochromatin;histone modification;induced pluripotent stem cell;Integrins;Invaded;Link;Malignant Neoplasms;Maps;Measures;mechanical force;mechanical properties;Mechanics;mechanotransduction;Mediating;melanocyte;Melanoma;Mouse Embryonic Stem Cells;Neoplasm Metastasis;novel strategies;Nuclear;Nuclear Inner Membrane;Nuclear Lamina;Nuclear Outer Membrane;Nuclear Protein;Nuclear Proteins;Pathologic Processes;Pathway interactions;Physiology;Piezo 1 ion channel;pluripotent stem cell differentiation;Pluripotent Stem Cells;Polymerase;Process;promoter;Proteins;Publishing;recruit;Reporting;response;RNA Polymerase II;self renewing cell;self-renewal;Signal Pathway;Site;stem cell differentiation;stem cell genes;stem cell self renewal;stem cells;stemness;Stress;Stretching;Structure;telomere;Telomere Shortening;Tertiary Protein Structure;Testing;transmission process;tumor;Up-Regulation

PROJECT_TITLE: Bioengineering approaches to map mechanotransduction in the living cell

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cannabidiol Research;Cannabinoid Research;Complementary and Integrative Health;Digestive Diseases;Genetics;Liver Disease;Natural Products;Patient Safety;Therapeutic Cannabinoid Research

ORG_CITY: JAMAICA

ORG_NAME: YORK COLLEGE

ORG_STATE: NY

PHR: Project Narrative The proposed research project is relevant to public health because the elderly represents a growing segment of cannabis users in the US; however, health consequences from cannabis use in this special population are currently unclear. The proposed project is the first to quantify the impact of both age and hepatic impairment or select cytochrome P450 (CYP) genetic variants on cannabinoid disposition. Results are expected to inform consumers, medical professionals, and key stakeholders, including those working in the residential aged-care industry, about the exposure-risk/benefit relationship of cannabinoid use among the elderly, as well as those with hepatic impairment or select CYP genetic variants.

PI_NAMEs: ZHOU, ZHU  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Adult;Adverse drug event;adverse event risk;Affect;Age;age effect;age related;Age related comorbidities;aged;aging process;American;Automobile Driving;Benefits and Risks;Blood flow;Cannabidiol;Cannabinoids;Cannabis;Cannabis sativa plant;Caring;Characteristics;Child;Clinical Research;comorbidity;Complex;Computer software;Conduct Clinical Trials;CYP2C19 gene;CYP2C9 gene;CYP3A4 gene;Cytochrome P450;Data;Databases;Development;Dose;Elderly;enzyme activity;Enzymes;Exposure to;Foundations;Future;Genetic;Genetic Polymorphism;genetic variant;Goals;Health;Health Professional;healthy aging;Hemp;Hepatic;Hepatic Mass;Herbal supplement;human old age (65+);Impairment;in silico;In Vitro;Individual;Industry;Ingestion;Inhalation;interest;Knowledge;Legal;Link;Liver;Liver diseases;Marijuana;marijuana use;marijuana user;Mediating;Medical;Medical Marijuana;Mental Depression;Metabolic Biotransformation;Metabolism;Minor;Modeling;models and simulation;novel;Oils;older patient;Oral;Pain;Patients;Pharmaceutical Preparations;pharmacokinetic model;Phenotype;Physiological;Plasma;Population;Public Health;Regimen;Renal function;Reporting;Research Project Grants;Risk Assessment;Safety;Severity of illness;Sleeplessness;Smoke;Special Population;Statutes and Laws;Tetrahydrocannabinol;THC concentration;THC exposure;trend;Variant;Xenobiotics;young adult

PROJECT_TITLE: Quantifying effects of comorbidities and genetics on cannabinoid exposure in the elderly


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: TSAILE

ORG_NAME: DINE' COLLEGE

ORG_STATE: AZ

PHR: Project Narrative: Because the COVID-19 pandemic has shown the dire need for more health care professionals on Navajo Nation, we will create pathways for high school and junior high school students to pursue Biomedical Sciences, Public Health, Allied healthcare and related STEM careers. Our approach is entrepreneurial and builds critical thinking and citizenship capacity (aligned with NGSS) by encouraging students to imagine innovative solutions and providing them with the resources to implement and test their hypotheses. Our strategy also includes the near-peer model which pairs Diné College students (mentors) with high school and junior high students from underserved communities, particularly Navajo Nation to build leadership capacity for college students, and create pathways to higher education in Biomedical Sciences/ STEM programs for pre K- K12 students.

PI_NAMEs: HAKIM, SHAZIA TABASSUM (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Advanced Development;Ally;Area;career;Collaborations;college;Communication;Communities;community organizations;COVID-19 pandemic;Critical Thinking;Curiosities;Development;Diné Nation;Disease;disease disparity;Dual Enrollment;Ecosystem;Education;Educational Curriculum;Enrollment;Epidemiology;Epistemology;experience;Family;Focus Groups;Fostering;Future;Harvest;Health;health care service;Health Disparities Research;health disparity;Health Fairs;Health Professional;Health Sciences;Healthcare;high school;higher education;human capital;Indigenous;Infection;innovation;Institution;Intervention;K-12 student;Knowledge;laboratory experience;Leadership;Learning;Link;Medicine;Mentors;Mentorship;Middle School Student;minority communities;Modeling;Modernization;Museums;Navajo;Needs Assessment;novel;Nursery Schools;Outcome;Pathway interactions;peer;Peer Group;peer networks;Private Sector;programs;Public Health;Research;Resources;Schools;Science;Source;STEM career;STEM program;Students;summer program;Support System;Testing;Time;Training Support;undergraduate education;undergraduate research;underserved community;underserved minority;university student;Workforce Development;Youth

PROJECT_TITLE: Convoy: A Cultural approach of Navajo Youth to Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Minority Serving Institutions (MSIs) are uniquely positioned to prepare the next generation of cutting-edge researchers from underrepresented minority groups, but faculty at MSIs still face several barriers in securing NIH grant funding for their research. To address this, we formed a partnership with 9 MSIs and created a program called Leading Emerging And Diverse Scholars to success (LEADS), which aimed to launch the research careers of postdoctoral fellows and junior faculty with a one-year fellowship where Scholars received professional skills training. Over the next five years, we will offer a two-year fellowship to Scholars, focusing on innovative new components based on feedback from the Scholars and the literature that includes personalizing the learning and making it experiential, enhancing mentoring, leveraging the benefits of team science to form research teams, and using the LEADS alumni network to serve as leaders and near-peer mentors to help Scholars succeed.

PI_NAMEs: RUBIO, DORIS M (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Active Learning;Address;Adopted;Advisory Committees;Area;Biomedical Research;career;Career Mobility;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;data management;Dedications;Development;Elements;Face;Faculty;Feedback;Fellowship;Funding;Goals;Grant;Individual;Infrastructure;innovation;Institution;Institutionalization;instructor;K-Series Research Career Programs;Leadership;Literature;Manuscripts;Mentors;Minority Groups;Minority-Serving Institution;next generation;peer coaching;personalized learning;plant growth/development;Positioning Attribute;Postdoctoral Fellow;Productivity;Program Sustainability;programs;Publications;Publishing;repository;Research;Research Personnel;Research Project Grants;Resources;Science;searchable database;Secure;Self Efficacy;Site;skill acquisition;skills;skills training;social media;success;symposium;theories;Time;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Visit;Work;Writing

PROJECT_TITLE: LEADS 2.0


NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Very large, complex datasets are being generated by cancer researchers using new proteomics technologies that allow them to study thousands of proteins simultaneously. This avalanche of data requires scientists well-trained in the specialized and multidisciplinary field of proteomics. Insufficient numbers of scientists are being trained in this rapidly growing field and this T32 proposes to address this issue. !

PI_NAMEs: RAO, ARVIND ;SARTOR, MAUREEN AGNES (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Proteogenomics of Cancer Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: SAN ANTONIO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Here we study tumor-intrinsic PDL1 signals in early carcinogenesis and progression using a novel autochthonous murine model in which mice develop NrasQ61R-mutant melanomas accelerated by UV exposure that lack PDL1 in the tumor cell-of-origin from initiation, definitively distinguishing biologic PDL1 signals versus compensatory mechanisms that could confound prior genetic PDL1KO studies. Our work defining tumor-intrinsic PDL1 signals in early carcinogenesis and their contribution to tumor progression and the tumor microenvironment provides insights into novel targetable ways in which PDL1 suppresses antitumor immunity. Our data can help improve melanoma treatments or response biomarkers.

PI_NAMEs: ONTIVEROS, CARLOS OSCAR (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Autophagocytosis;Benign;Bioinformatics;Biological;BRAF gene;cancer cell;cancer imaging;cancer immunotherapy;carcinogenesis;carcinogenicity;career development;Cell Line;Cells;chemokine;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;confocal imaging;cytokine;Data;DDR1 gene;Dependence;DNA Damage;Dose;experimental study;Exposure to;FDA approved;Flow Cytometry;Generations;Genetic;Harvest;Image;Immune;immune cell infiltrate;Immune Evasion;immunodeficiency;immunogenic;immunogenicity;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;insight;Interferon Type I;Interferons;Investigation;Knowledge;Malignant - descriptor;Malignant neoplasm of ovary;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical;MEKs;melanocyte;Melanoma;Melanoma Cell;Melanoma Tumor;melanomagenesis;Mentors;Modeling;mouse model;Mus;mutant;Mutate;neoplastic cell;Nevus;Non-Malignant;novel;novel therapeutics;Oncogenic;Outcome;Pathologic;Pathway interactions;pharmacologic;Population;Prediction of Response to Therapy;Production;programmed cell death ligand 1;programmed cell death protein 1;Proteomics;Quantitative Reverse Transcriptase PCR;Regulation;Reporting;response;response biomarker;Role;Signal Pathway;Signal Transduction;skills;Skin;small molecule;small molecule inhibitor;Stimulator of Interferon Genes;Surface;T-Cell Depletion;Testing;therapy resistant;Time;Training;transcriptome sequencing;transcriptomics;Translating;Transplantation;Treatment Efficacy;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Stem Cells;Tumor-Derived;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;UV Radiation Exposure;Western Blotting;Work

PROJECT_TITLE: The role of tumor cell-of-origin-specific PDL1 on tumorigenesis and tumor progression


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Modular polyketide synthases are enzymatic assembly lines that naturally synthesize many important human medicines and drug leads. If their synthetic abilities were harnessed, medicines could be developed much more rapidly. Through a new understanding of the polyketide synthase module and new technology developed by our lab, we are able to rapidly engineer highly active synthases and use them in the development of much needed antibiotics.

PI_NAMEs: KEATINGE-CLAY, ADRIAN TRISTAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Harnessing Polyketide Assembly Lines for Medicinal Chemistry

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Cancer cells rely on the DNA damage sensor kinase ATR to tolerate chemotherapy-induced replication stress. The use of ATR inhibitors in combination with chemical stressors of the DNA replication process has revealed strong therapeutic synergies, but the mechanisms behind these synergies are unclear due to the complexity of the ATR signaling response. By mapping and barcoding cancer- and drug-specific ATR signaling responses using unbiased mass spectrometry techniques, this work will compare molecular signatures and respective cellular outcomes to identify potential mechanisms of clinically relevant chemotherapeutic synergies.

PI_NAMEs: COMSTOCK, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Bar Codes;Biochemical;Biological;Camptothecin;cancer cell;Cancer cell line;cancer therapy;cancer type;Cell Survival;cell type;Cells;Chemicals;Chemoresistance;chemotherapeutic agent;chemotherapy;Chronic;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Combined Modality Therapy;Data;Dissection;DNA;DNA biosynthesis;DNA Damage;DNA Repair;Drug Synergism;Drug Targeting;ds-DNA;Event;Excision;Exhibits;experimental study;Generations;Genes;Genetic;Genomic Instability;genotoxicity;HCT116 Cells;Human;Hybrids;inhibitor;insight;Knowledge;Libraries;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Molecular;Molecular Profiling;Monitor;Mutate;novel;nuclease;Oncogenes;Outcome;overexpression;Pharmaceutical Preparations;Pharmacotherapy;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;Poison;Poly(ADP-ribose) Polymerase Inhibitor;Predisposition;Process;Proteins;refractory cancer;Regulation;replication stress;Replication-Associated Process;Resistance;Resolution;response;ribonuclease H1;RNA;RNA Processing;Role;scale up;sensor;Signal Induction;Signal Transduction;Source;stressor;Structure;synergism;Synthetic Peptide Libraries;System;Techniques;Therapeutic;therapy outcome;Topoisomerase;Work

PROJECT_TITLE: Uncovering ATR signaling networks underlying chemotherapeutic synergies


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Opioid Misuse and Addiction;Opioids;Orphan Drug;Pain Research;Palliative Care;Rare Diseases;Substance Misuse

ORG_CITY: Loma Linda

ORG_DEPT: DENTISTRY

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: PROJECT NARRATIVE Head and neck cancer is one of the most painful malignancies, and is woefully unresponsive to even high doses of opioids. This study will 1) establish the relationship between pain experienced by head and neck cancer patients and specific genes that are silenced by methylation, 2) therapeutically target identified genes using a preclinical model, and 3) provide training to further the career development of the applicant as a surgeon scientist. The study has the potential to lead to a non-opioid treatment for head and neck cancer pain.

PI_NAMEs: VIET, CHI T. (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Adenoviruses;Advisory Committees;Affect;alternative treatment;antinociception;Anxiety;Area;Binding;Bioinformatics;Biological Markers;Breast;Brief Pain Inventory;cancer cell;Cancer Control;cancer pain;Cancer Pain Management;Cancer Patient;cancer site;cancer subtypes;cancer therapy;career;career development;Clinical;clinical pain;Clinical Research;clinically relevant;Data;design;Development;Development Plans;Disease;DNA Methylation;Doctor of Philosophy;Dose;drug discovery;Eating;effective therapy;endogenous opioids;Endothelin;Endothelin B Receptor;Enrollment;Epigenetic Process;epigenetic silencing;European Organization for Research and Treatment of Cancer;Exhibits;experience;Funding;gene discovery;gene product;Gene Silencing;gene therapy;gene-targeted therapy;Genes;genome wide methylation;Goals;Guidelines;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;High Prevalence;Human Resources;Hypermethylation;improved;Individual;inflammatory pain;intense pain;interest;Intervention;Knowledge;Laboratories;Lung;malignant mouth neoplasm;Malignant Neoplasms;Maps;Mediating;meetings;Mental Depression;Mentorship;Methylation;methylation pattern;Molecular;Morphine;mouse model;mu opioid receptors;Neoplasm Metastasis;Neurons;non-opioid analgesic;novel;Opiate Addiction;opiate tolerance;Opioid;opioid epidemic;Pain;Pain management;Pain Measurement;pain model;pain processing;pain relief;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;preclinical trial;prescription opioid;Prevalence;prospective;Prospective Studies;Prostate;psychosocial;Quality of life;Questionnaires;Receptor Activation;receptor expression;Research;research and development;Research Project Grants;Risk;risk mitigation;Role;Scientist;Series;stress related disorder;Structure;Surgeon;symptomatology;therapeutic target;Time;Tissues;Training;Translational Research;translational research program;translational study;Viral Genes;Work

PROJECT_TITLE: Clinical study to evaluate the methylation signature of head and neck squamous cell carcinoma pain

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative l Studies of human neurodevelopment and neurodevelopmental disorders suffer due to a lack of adequate model systems. To address this urgent need, my proposed work seeks to identify an engineered biomaterials system that is both permissive and instructive in guiding reproducible neural organoid maturation to develop a robust human stem cell-based neural organoid culture platform. This interdisciplinary approach will facilitate the fusion of organoids representing different brain regions (to form assembloids) to study temporally critical development processes and progenitor migration in a disease model of 22q11.2 deletion syndrome, revealing important fundamental insights into brain development and disease.

PI_NAMEs: HUANG, MICHELLE S (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 22q11.2;3-Dimensional;Address;Affect;Age;Architecture;Behavior;Biochemical;Biochemistry;Biocompatible Materials;Biological Models;Biomechanics;Biomedical Engineering;biophysical properties;Biophysics;Brain;Brain region;brain tissue;Cells;Chemicals;Child;Collaborations;Complex;covalent bond;crosslink;Cues;Defect;design;Development;DiGeorge Syndrome;Disease;disease model;DNA;Dorsal;Drug Screening;Educational workshop;Elasticity;empowerment;Encapsulated;Engineering;Environment;experience;experimental study;Extracellular Matrix;Gel;Gene Deletion;Genetic Screening;Growth;Heterogeneity;Human;human model;human stem cells;Hyaluronic Acid;Hydrogels;immunocytochemistry;Impairment;improved;In Vitro;in vitro Model;induced pluripotent stem cell;innovation;insight;interdisciplinary approach;Interneurons;Label;Laminin;Ligands;Liquid substance;live cell microscopy;Manuals;matrigel;Mechanics;Mediating;Mentorship;migration;Modeling;Monitor;mouse model;Mus;Nervous System Disorder;neural;neurodevelopment;Neurodevelopmental Disorder;novel;Organoids;Outcome;overexpression;Patients;Pattern;permissiveness;Phenotype;PicoGreen;Positioning Attribute;prevent;Process;Productivity;Proliferating;Property;Prosencephalon;protein crosslink;Protocols documentation;Recombinants;Relaxation;Reproducibility;Research;Research Ethics;Research Proposals;response;Role;Sarcoma;scale up;Scientist;self organization;Series;Signal Transduction;single-cell RNA sequencing;skills;spheroids;stem cell migration;stem cells;Stress;Structure;Supine Position;Suspensions;symposium;System;Technical Expertise;Testing;Time;Tissues;Training;Transfection;United States;viscoelasticity;Western Blotting;Work;Writing

PROJECT_TITLE: An Engineered Hydrogel Platform to Improve Neural Organoid Reproducibility for a Multi-Organoid Disease Model of 22q11.2 Deletion Syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Over half of the US population consumes more added sugars than is recommended by the 2015-2020 Dietary Guidelines for Americans. The proposed research is relevant to public health because it will identify theory-based interventions with the potential to increase the proportion of dentists involved in the dissemination and implementation of sugar reduction policies and programs for dental caries prevention. Thus, the proposed research is relevant to NIDCR's mission to improve dental, oral, and craniofacial health through research, research training, and the dissemination of health information.

PI_NAMEs: KEARNS, CRISTIN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Achievement;Adopted;Adoption;Advertisements;American;Award;Behavior;behavior change;behavior change wheel;behavioral and social science;Belief;Beverages;California;Calories;cardiovascular disorder risk;career;Caries prevention;Communication;Communities;Complement;Consensus;Consumption;craniofacial;Cues;Data;Dental;Dental caries;Dentistry;Dentists;Development;dietary guidelines;Dissemination and Implementation;dissemination science;Education;effective intervention;Effectiveness;Evaluation;evidence base;Evidence based intervention;Feeling;Focus Groups;Fostering;Goals;Health;implementation science;improved;Industry;innovation;Intake;Intervention;Interview;Knowledge;Label;Licensing;member;Mentorship;Methods;Mission;Modeling;Motivation;National Institute of Dental and Craniofacial Research;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;Oral health;outreach;Persuasive Communication;pilot test;Policies;Policy Research;Population;Positioning Attribute;prevent;Price;Process;program dissemination;programs;provider behavior;public education;Public Health;public health intervention;Public Relations;Publishing;Questionnaires;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;Sampling;San Francisco;scale up;Scheme;Schools;Scientist;social;social science research;Source;Speed;statistics;Strategic Planning;sugar;Surveys;Taxation;Taxes;Techniques;Testing;theories;therapy design;Training;Translational Research;Translations;Universities;warning label;Water fluoridation;Work;Workplace

PROJECT_TITLE: Overcoming Barriers to Implementing Policies to Reduce Sugar Consumption for Dental Caries Prevention


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Natural Products;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Accelerated decline in physical function is a common adverse health effect of breast cancer chemotherapy linked to premature frailty, disability, and death. We hypothesize that targeting senescent cells, using exercise and treatments that ablate senescent cells, will improve chemotherapy-induced functional decline. If our hypothesis is correct, the impact on clinical practice would be substantial and will extend far beyond oncology.

PI_NAMEs: SEDRAK, MINA S (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Ablation;Acceleration;Address;Adherence;Age;age acceleration;age related;Aging;aging biomarker;aging process;aging related;arm;Biological Aging;Biological Markers;Breast Cancer survivor;Breast Cancer Treatment;Cancer Patient;cancer therapy;CD3 Antigens;CDKN2A gene;Cell Aging;Cell Cycle Arrest;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic Disease;Clinical;Clinical Markers;clinical practice;comparative efficacy;Data;design;Diabetes Mellitus;dietary supplements;disability;efficacy evaluation;efficacy testing;Exercise;exercise program;exercise training;experience;falls;Fatigue;fisetin;frailty;functional decline;Functional disorder;Geriatric Assessment;Growth;Health;improved;Inflammation;Inflammatory;Intervention;late life;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;middle age;muscle form;Neuropathy;older adult;older patient;Oncology;Oral;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physical Function;Population;Postmenopause;preclinical study;premature;prevent;primary endpoint;Process;Public Health;Pulmonary Fibrosis;Quality of life;Randomized;randomized placebo controlled trial;restoration;Risk;safety assessment;secondary endpoint;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Survivors;T-Lymphocyte;tele-exercise;Testing;therapy design;Tissues;Toxicity due to chemotherapy;treatment arm;Treatment-related toxicity;United States National Institutes of Health;Walking;Woman;Work;young adult

PROJECT_TITLE: Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Therapies to treat AD in DS are urgently needed. This application seeks to utilize the existing expertise and experience of the Alzheimer's Clinical Trial Consortium (ACTC), Alzheimer's Biomarker Consortium for Down Syndrome (ABC-DS) and Horzion21 to establish a Trial Ready Cohort to conduct AD therapeutic trials in adults with DS in a thoughtful, ethical and scientifically-rigorous manner.

PI_NAMEs: RAFII, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Award;Biological Markers;Brain;brain volume;Cause of Death;Chromosome 21;Clinical;Clinical assessments;clinical trial readiness;Clinical Trials;Cognitive;cohort;Collaborations;Conduct Clinical Trials;Congenital chromosomal disease;Data;data management;Dementia;dementia risk;Disease;Disease Marker;Disease Progression;Double-Blind Method;double-blind placebo controlled trial;Down's Syndrome;electronic data capture system;Enrollment;Ethics;European;Exhibits;experience;Funding;Future;Gene Proteins;General Population;Genes;Genetic;Hippocampus;Image;Immunotherapy;Impaired cognition;improved;Individual;Infrastructure;Intellectual functioning disability;lifetime risk;Link;Liquid substance;Magnetic Resonance Imaging;Measures;Methods;Modification;Monitor;mRNA Expression;Mutation;Neurofibrillary Tangles;neuropathology;non-demented;Outcome Measure;Participant;Pathogenesis;Pathway interactions;performance site;Persons;Phase;phase II trial;Placebo Control;Placebos;Plasma;Play;Population;Positron-Emission Tomography;prevent;Procedures;progression marker;protein expression;Randomized;Role;Running;Safety;Senile Plaques;Site;tau Proteins;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;Treatment outcome;trial readiness;United States National Institutes of Health;working group

PROJECT_TITLE: Clinical trials to prevent Alzheimer's Disease in Down Syndrome


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Natural Products;Osteoarthritis;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: VAIL

ORG_NAME: STEADMAN PHILIPPON RESEARCH INSTITUTE

ORG_STATE: CO

PHR: Project Narrative: A clinical trial is proposed to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently or in combination, to improve the beneficial effect of bone marrow derived stem cells (derived from bone marrow aspirate concentrate) for improving outcomes in patients with knee osteoarthritis. These proposed clinical trials will build upon a currently active clinical trial on orthobiologics at TSC/SPRI for OA treatment at SPRI utilizing the same patient population and outcomes assessments to effectively provide a 6-arm, comprehensive assessment of biological therapies for improving treatment of osteoarthritis.

PI_NAMEs: HUARD, JOHNNY  (contact);PHILIPPON, MARC ;TASHMAN, SCOTT

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Adipose tissue;Adult;adult stem cell;adult stem cell transplantation;Aftercare;Age;Allografting;antifibrotic treatment;Apoptosis;Apoptotic;arm;arthropathies;articular cartilage;Autologous;Biological Markers;Biological Response Modifier Therapy;Blood;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Stem Cell;Cartilage;cartilage degradation;Cartilage Diseases;cartilage repair;Cell Aging;Cell Death;cell type;Cells;chemokine;Chondrocytes;Clinic;Clinical;clinical efficacy;clinical translation;Clinical Trials;Combined Modality Therapy;cytokine;Data;Degenerative polyarthritis;design;Development;dietary supplements;Disease;Double-Blind Method;FDA approved;Fibrocartilages;Fibrosis;fisetin;Goals;Grant;Harvest;Homeostasis;Hyaline Cartilage;Image;Impairment;implantation;improved;improved outcome;In Vitro;Individual;Inflammation;Inflammatory;inhibitor;Injury;Intervention;Investigation;joint destruction;Joints;kinematics;Kinetics;Knee joint;Knee Osteoarthritis;Laboratories;Losartan;loss of function;Magnetic Resonance Imaging;Metabolic;minimally invasive;Morphology;Motion;Mus;Natural regeneration;novel strategies;Operative Surgical Procedures;osteochondral tissue;Outcome;Pain;Pain Measurement;pain outcome;Pathway interactions;Patient Outcomes Assessments;patient population;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Phase I/II Trial;pre-clinical;Pre-Clinical Model;prevent;Progressive Disease;Randomized;randomized, clinical trials;regeneration potential;Regimen;repaired;Replacement Arthroplasty;Research Institute;Research Personnel;Resistance;Safety;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;Skeletal Muscle;stem cell function;stem cell therapy;stem cells;Structure;symptom treatment;Synovial Fluid;Technology;Time;Tissues;Transforming Growth Factors;Transplantation;Treatment Efficacy;Treatment outcome;Work

PROJECT_TITLE: The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Physical Activity;Substance Misuse;Underage Drinking

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: C7/8 UO1: Lisa Savage & Ryan Vetreno Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits Project Narrative Heavy adolescent alcohol consumption is associated with frontal cortical pathology and impaired decision making. Loss of cholinergic neurons and function is observed after adolescent alcohol exposure. This project rescues cholinergic neurons to restore cognitive function in an animal model of adolescent alcohol exposure.

PI_NAMEs: SAVAGE, LISA M (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Acetylcholine;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;Adult;aged;Alcohol consumption;alcohol exposure;Alcohols;Alzheimer's Disease;Animal Model;Anxiety;ATAC-seq;Attention;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;Brain;Brain Injuries;Cells;cholinergic;Cholinergic Fibers;cholinergic neuron;Chromatin;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cognitive function;Complement;Complex;connectome;Coupled;Data;Decision Making;density;designer receptors exclusively activated by designer drugs;Development;discounting;Dissection;drinking;early adolescence;effective therapy;EP300 gene;Epigenetic Process;epigenetic regulation;epigenetic silencing;Ethanol;Exercise;Exercise Therapy;flexibility;frontal lobe;Functional disorder;gene therapy;Genes;Genetic;Goals;Growth Factor Gene;human model;Impaired cognition;Impairment;innovation;knock-down;Maintenance;Maps;Medial;Mediating;Mediator;Modeling;Monkeys;Nerve Degeneration;Nerve Growth Factors;nerve supply;nestin protein;Neurodegenerative Disorders;neuroimaging;Neuroimmune;neuron loss;Neurons;neuroprotection;NGFR gene;NGFR Protein;Nucleus Basalis Magnocellularis;Pathologic;Pathology;Pattern;Phenotype;phenotypic biomarker;Prefrontal Cortex;Process;Prosencephalon;Rattus;Recovery;reinnervation;Research;restoration;Reversal Learning;Rodent Model;Role;Short-Term Memory;Signaling Molecule;Site;Source;Structure;Techniques;Testing;tool;underage drinking;Viral

PROJECT_TITLE: 7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: WASHINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Public Health Narrative The proposed research is relevant to public health because its findings would contribute to evidence-informed policies regarding family media ecology and be used to tailor interventions to the specific needs of individual families. These findings will also be relevant to ongoing policy debate surrounding the need for regulation of media content and for child-centered design to support healthy developmental trajectories in the digital age. Thus, the proposed research is relevant to NICHD’s mission as it pertains to early exposure to digital media and discovering how digital media use affects socio-emotional development in early childhood.

PI_NAMEs: BARR, RACHEL F. (contact);COYNE, SARAH ;KIRKORIAN, HEATHER ;RADESKY, JENNY S

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 2 year old;3 year old;5 year old;7 year old;Address;Affect;Age;aged;autism symptoms;Child;Code;Cognitive;cohort;Cohort Effect;Complex;cost effective;COVID-19;COVID-19 pandemic;Data;Data Analyses;Data Analytics;Data Collection;data platform;data reuse;Data Set;data sharing;data streams;Databases;design;Development;diaries;digital;digital media;Distal;early childhood;Ecology;emotion regulation;Emotional;Enrollment;Environment;Exposure to;Family;Family Characteristics;Future;Goals;handheld mobile device;Health;Home;improved;indexing;Individual;Infant;innovation;Interdisciplinary Study;Intervention;Joints;lens;longitudinal dataset;Longitudinal Studies;Marketing;Measurement;Measures;media use;Methods;middle childhood;Mission;Modeling;National Institute of Child Health and Human Development;Obesity;Online Systems;open source;Outcome;pandemic disease;pandemic stressor;Parents;Pattern;Policies;post-pandemic;pre-pandemic;predictive modeling;Predisposition;programs;Psychosocial Stress;Public Health;Questionnaires;Race;rapid growth;Regulation;Reporting;Reproducibility;Research;Research Infrastructure;response;Sampling;Science;sharing platform;social;Social Interaction;social skills;socioeconomics;Source Code;Speed;System;Temperament;Testing;Time;time use;Toddler;tool;Variant;Vision;Visualization;Work

PROJECT_TITLE: Growing up in a digital world: A synergistic approach to understanding media use in children ages 1-8 years


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

PI_NAMEs: KIRKORIAN, HEATHER  (contact)

PROJECT_TERMS: Address;Age;base;Behavior;behavior prediction;burnout;Child;Child Behavior;Child Development;Child Rearing;coping;COVID-19 pandemic;Data;Data Analyses;Development;digital;digital media;Ecological momentary assessment;Ecology;Emotional;Emotions;experience;Family;Gatekeeping;Goals;Individual;Infant;Infant Development;innovation;Intervention;Joints;Lead;lens;Literature;Measures;media use;Mediating;Mediator;Mental Health;Methods;multidisciplinary;Outcome;parental influence;Parents;Pattern;Persons;Policies;Positioning Attribute;Research;Resources;Science;Scientific Advances and Accomplishments;skills;Stress;Testing;Time;Update;Work

PROJECT_TITLE: Putting infants' media exposure in context: The Ecology of Media Use (EMU) study


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The goal of this F31 NRSA Predoctoral Fellowship to Promote Diversity in Health-Related Research project is to develop new MR molecular imaging hardware and techniques to better detect aggressive cancers metastasizing beyond the prostate gland and local spread to the prostatic bed & adjacent lymph nodes. This is of particular relevance for identifying and treating patients presenting with advanced stage disease which is two-fold higher in African-American men.

PI_NAMEs: GEBREZGIABHIER, DANIEL TEWELDE (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 3-Dimensional;3D Print;Address;advanced disease;advanced prostate cancer;African American;African-American Graduate Student;Anatomy;Anterior;Award;Beds;Biomedical Engineering;Biomedical Research;Biopsy;Black race;bone;cancer imaging;Cancer Patient;career;career development;Clinical;clinical care;Clinical Management;Clinical Research;Code;Collaborations;Complex;computer design;Coupling;Death Rate;design;design and construction;Detection;detector;Development;Development Plans;Disease;Distant;Education;Electronics;Elements;Eligibility Determination;Engineering;experience;Extracapsular;Fellowship;Frequencies;Funding;Geometry;Goals;graduate student;Grant;Head;Health;healthy volunteer;Image;improved;Incidence;industry partner;Infrastructure;interest;Joints;Knowledge;Learning;Liver;Localized Malignant Neoplasm;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;member;men;Metabolic;Methods;minority scientist;Modernization;molecular imaging;National Research Service Awards;Neck;Neoplasm Metastasis;Newly Diagnosed;Noise;Not Hispanic or Latino;novel;Nursing Research;Organ;Patients;Performance;performance tests;Periprostatic;Phase I Clinical Trials;pre-doctoral;professor;programs;Prostate;Prostatic;prototype;Pyruvate;radiologist;reconstruction;Research;Research Design;Research Project Grants;research study;Research Training;Residual state;RF coil;Risk;safety testing;Scanning;Science;Signal Transduction;simulation;Site;skills;Software Design;software development;Staging;Statistical Study;Students;Techniques;technology development;Testing;Time;Training;transmission process;treatment response;ultrasound;Underrepresented Minority;Underrepresented Populations;volunteer

PROJECT_TITLE: New Hardware and Software Developments for Improving Prostate Metabolic MR Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


NIH_SPENDING_CATS: Aging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Glioblastoma is the most aggressive and common form of primary brain cancer with a median patient survival time of ~ 15 months. Professor Luis Parada at Sloan Kettering Cancer Institute have established the mouse model and faithfully phenocopy the tumor genesis. This proposal will use single cell RNAseq, single cell ATACseq and multi-photon imaging to probe tissue stem cell and cancer initiation cell transcriptional regulation network, heterogeneity and immune privilege.

PI_NAMEs: ZHANG, CHI  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Affect;Aging;Animals;anti-cancer research;Antigen Presentation;Antigen Presentation Pathway;ATAC-seq;Basement membrane;Binding;cancer cell;cancer heterogeneity;cancer initiation;cancer stem cell;career;Cell Adhesion;cell behavior;Cell division;Cell Lineage;cell motility;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;combat;combinatorial;computerized tools;Data;Enhancers;Event;Extracellular Matrix;FOXC1 gene;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;Genetically Engineered Mouse;genome wide association study;genomic tools;Glioblastoma;Goals;Hair follicle structure;Heterogeneity;Homeostasis;Human;Image;imaging system;Immune;In Vitro;in vivo;Individual;insight;intravital imaging;Investigation;Knock-out;Knockout Mice;Knowledge;Life Expectancy;Link;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Methodology;Miniaturization;Molecular;mouse model;movie;multi-photon;multiphoton imaging;mutant;Mutation;Natural regeneration;NF1 gene;Normal tissue morphology;pathogen;Patients;Phase;Phenocopy;Play;Population;posttranscriptional;Premature aging syndrome;Process;professor;programs;promoter;Regulation;Research;Research Personnel;Resolution;Role;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Skin;spatiotemporal;stem cell aging;stem cell exhaustion;stem cell function;stem cell niche;stem cell self renewal;stem cells;System;T-Lymphocyte;Techniques;Testing;Time;tissue stem cells;Tissues;tool;TP53 gene;Training;transcription factor;Transcriptional Regulation;transcriptomics;tumor;tumor microenvironment;tumor progression;tumorigenesis;Visualization;Work

PROJECT_TITLE: Perturbation based single cell investigation of tumor micro-environment


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative A large investment in time and money is made to support neuroimaging research to understand how brain structure and function develops and ages, and how various disorders affect it. However, much of this research, while very valuable, is performed on a relatively small number of subjects and is reported in a way that makes it difficult to replicate or assess its generalization across the population. ReproNim: A Center for Reproducible Neuroimaging Computation, provides a re-executable framework for capturing data and performing neuroimaging analysis. In this renewal, we seek to improve the efficiency of this framework in support of improving all clinical and research studies using neuroimaging.

PI_NAMEs: KENNEDY, DAVID NELSON (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Age;analytical method;Archives;Area;Basic Science;Big Data;Biomedical Engineering;biomedical imaging;Bite;Brain;BRAIN initiative;Clinical;clinical application;Clinical Research;Collaborations;Communities;Complement;complex data;Computer software;Coupled;Data;data acquisition;Data Aggregation;data management;data modeling;Data Set;data sharing;Dedications;design;Development;Discipline;Disease;Disparate;Elements;Environment;Face;Feedback;First Independent Research Support and Transition Awards;Fostering;Goals;Human;improved;Individual;informatics infrastructure;Infrastructure;innovation;Institution;International;Investments;Knowledge;Literature;Methods;Mission;Modeling;neuroimaging;new technology;open data;open source;operation;Patients;Phase;Population;prevent;Procedures;Process;Publication Bias;Publications;Readability;Reporting;Reproducibility;Research;Research Personnel;research study;Research Subjects;Research Training;Resources;response;Role;Science;Scientific Advances and Accomplishments;Scientist;Services;skills;social;Software Tools;Standardization;Statistical Data Interpretation;Structure;success;System;Systems Analysis;Technology;technology development;technology research and development;Testing;Time;tool;Training;Training and Education;United States National Institutes of Health;Work


PI_NAMEs: RADESKY, JENNY S (contact)

PROJECT_TERMS: 8 year old;Adolescence;Adoption;Age;American;Articulation;Attention;Behavior;Behavior Therapy;behavioral response;caregiving;Cellular Phone;Characteristics;Child;Child Development;Child Health;Child Rearing;Childhood;Classification;Cognitive;cognitive load;Computers;Cues;Data Collection;design;Development;Devices;digital;digital ecosystem;digital media;Disadvantaged;early childhood;Educational workshop;emotion regulation;Emotional;emotional functioning;Environment;Equation;evidence base;executive function;Exhibits;experience;externalizing behavior;Family;Feeling;Frequencies;Guidelines;handheld mobile device;Home visitation;Hour;Household;Individual;Infant;Interruption;Interview;Knowledge;Life;Longitudinal cohort study;media use;Mental Health;Michigan;Modeling;National Institute of Child Health and Human Development;negative affect;news;novel;Outcome;Parent-Child Relations;Parents;Pathway interactions;Play;Policies;Population;Predisposition;programs;Psychosocial Stress;psychosocial stressors;Reading;Recommendation;Reporting;Research;Research Personnel;Resistance;response;Shapes;skills;Sleep;social;social influence;social media;social skills;Stress;Tablets;Technology;Television;Temperament;Testing;Time;Toddler;touchscreen;tv watching;virtual;Well in self;Work

PROJECT_TITLE: Michigan Interactive Tech in Toddlers (MITTen) study


NIH_SPENDING_CATS: Biotechnology;Neurosciences

PROJECT_TERMS: Adoption;Affect;Age;Attention;Basic Science;Behavior;Biomedical Technology;Brain;Clinical;Clinical Research;Communities;community advisory board;Data;data management;Data Set;data sharing;Decision Making;Dedications;Development;Disease;Disparate;Educational workshop;Effectiveness;Equity;Evaluation;First Independent Research Support and Transition Awards;Fostering;Goals;Hearing;Human Resources;improved;informatics infrastructure;innovation;Institution;International;Investments;Knowledge;Literature;meetings;member;Methods;Mission;Monitor;National Institute of Biomedical Imaging and Bioengineering;neuroimaging;neuroinformatics;operation;Phase;Population;Process;programs;Publications;Publishing;Reporting;Reproducibility;Research;Research Personnel;research study;Resource Development;Resources;response;Schedule;Science;Services;Structure;System;Technology;technology development;technology validation;Time;tool;Training;United States National Institutes of Health;Voice;Work;working group

PROJECT_TITLE: ReproNim: A Center for Reproducible Neuroimaging Computation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Prevention

PI_NAMEs: COYNE, SARAH  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Behavior;behavior prediction;behavioral outcome;Birth;Child;Child Development;Child Rearing;Childhood;cohort;Crying;daily functioning;Development;Devices;diaries;digital;digital media;digital technology;early childhood;Early identification;Early Intervention;emerging adult;emotion regulation;Environment;Equilibrium;executive function;Goals;Growth and Development function;Habits;high risk population;Hour;Impairment;Individual;innovation;Knowledge;Life;longitudinal analysis;Longitudinal Studies;media use;member;Methodology;Methods;middle childhood;Nature;Outcome;Parent-Child Relations;Parents;Pathologic;peer;Play;prevent;prospective;Public Health;Research;Research Personnel;Role;sample fixation;Sampling;Schools;social skills;Time;time use;Transact;Work

PROJECT_TITLE: Predictors of Problematic Media Use in Middle Childhood: Project M.E.D.I.A


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The overarching goal of this K01 Career Development Award is to foster Dr. Sunita Desai’s transition to independence, as a health economist with expertise in policy design for vulnerable populations and providers of safety net care. The proposed study, which is the first step in Dr. Desai’s transition, will investigate whether the 340B Drug Pricing Program, an expansive policy that directs financial resources to providers of safety net care, has achieved its goal of improving care quality and medication access for vulnerable populations and/or has had unintended spillover effects on drug spending among privately-insured patients. Findings from this work will yield direct policy implications pertaining to the 340B Drug Pricing Program and useful generalizations regarding the design of policies that intend to give health care providers both the resources and incentives to deliver high-quality and accessible health care for the most vulnerable Americans.

PI_NAMEs: DESAI, SUNITA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Designing policies to incentivize high-quality health care for vulnerable Americans: Evidence from the 340B Drug Pricing Program

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Biotechnology;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Adopted;Affect;Age;annotation  system;Brain;brain behavior;Clinical;Clinical Research;cohort;Collaborations;Collection;Common Data Element;Communities;Complement;Complex;Computer software;Data;data access;Data Aggregation;Data Discovery;data ecosystem;Data Element;data exploration;data harmonization;data management;data reuse;Data Science;data sharing;Disease;distributed data;Documentation;empowerment;Ensure;Environment;experience;FAIR principles;Foundations;Funding;Generations;Graph;Human;improved;information model;Infrastructure;interest;interoperability;Intuition;Investments;Knowledge;meetings;Metadata;neuroimaging;novel;Policies;Population;preservation;Procedures;Process;Production;Protocols documentation;Publications;Publishing;Pythons;query tools;Reporting;Reproducibility;Research;Research Personnel;research study;Research Support;Resources;Science;Secure;Semantics;Services;Source;Standardization;Structure;support tools;synergism;System;Technology;technology research and development;Terminology;Time;tool;Training;Training Activity;Training Support;Trust;United States National Institutes of Health;Universities;Vocabulary;Work

PROJECT_TITLE: A FAIR Data and Metadata Foundation for Reproducible Research


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Head and Spine Injury

ORG_CITY: Irvine

ORG_NAME: NEURAEGIS, INC.

PHR: Narrative There are currently no drugs that provide neuroprotection after status epilepticus. While calpain has been proposed to participate in the development of epilepsy as well as other neurodegenerative disorders, there are no calpain inhibitors in the clinic. The present studies will test the hypothesis that a selective calpain-2 inhibitor could prevent the occurrence of spontaneous recurring seizures following a seizure episode in two mouse models of epilepsy, in addition to preventing several manifestations of neuropathology. These studies will provide critical information to support the clinical development of a selective calpain-2 inhibitor for the treatment of epilepsy.

PI_NAMEs: BAUDRY, MICHEL  (contact);BI, XIAONING

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acute;Address;Affect;analog;Animals;anti-epileptic agents;Antiepileptogenic;Appearance;astrogliosis;axonal degeneration;Biotechnology;blood-brain barrier crossing;Brain;Brain Concussion;brain dysfunction;Brain Injuries;C57BL/6 Mouse;Calcium;Calpain;calpain inhibitor;Chronic;Clinic;clinical candidate;clinical development;conditional knockout;conditioned fear;cost estimate;Data;design;Development;Disease;Dose;Drug resistance;effectiveness evaluation;effectiveness testing;Electroencephalography;Encephalitis;Epilepsy;Epileptogenesis;Event;excitatory neuron;Exhibits;Family;Formulation;Frequencies;glial activation;glial cell development;Glial Fibrillary Acidic Protein;Hippocampus;Immunohistochemistry;Impaired cognition;inhibitor;Injections;Injury;Intranasal Administration;Intravenous;Kainic Acid;Knockout Mice;Laboratories;Lead;Learning;Location;Migraine;Modeling;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuron loss;Neuronal Injury;Neurons;neuropathology;neuroprotection;novel;Pathologic;Patient Compliance;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilocarpine;prevent;Process;Property;Prosencephalon;Protein Isoforms;Rattus;Recurrence;Route;Seizures;Severities;side effect;Small Business Technology Transfer Research;Stains;Status Epilepticus;Stroke;Testing;Therapeutic;therapeutic target;Traumatic Brain Injury;Video Recording;Wild Type Mouse

PROJECT_TITLE: Testing the effects of a selective calpain-2 inhibitor on spontaneous recurrent seizures in mouse models of epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: BARR, RACHEL F. (contact)

PROJECT_TERMS: 2 year old;3 year old;7 year old;Address;Age;aged;analytical tool;Books;Child;Code;cohort;Complex;COVID-19;COVID-19 pandemic;Data;Data Analyses;Data Analytics;data cleaning;data integration;data management;data repository;data reuse;Data Set;data sharing;data streams;data structure;data visualization;Databases;design;diaries;digital;Ecology;emotion regulation;Emotional;Environment;experience;Family;Goals;Grant;handheld mobile device;Household;indexing;Infrastructure;Joints;Libraries;longitudinal dataset;Longitudinal Studies;machine learning model;Marketing;Measures;media use;Methods;Online Systems;open data;open source;Outcome;pandemic disease;Pattern;Postdoctoral Fellow;Predisposition;Process;Psychosocial Stress;Questionnaires;Race;Reproducibility;Research;Research Personnel;response;Sampling;Science;Secure;shared repository;sharing platform;social skills;socioeconomics;Source Code;Stream;Surveys;time use;Toddler;training opportunity;United States National Institutes of Health;Variant;Visualization


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE: The ability to generalize from past experience is essential to our daily lives as we rarely encounter precisely the same situation twice, but little is known about how the brain generalizes from past experience. An understanding of the neural processes underlying this fundamental cognitive ability could provide important foundational knowledge for understanding how it may be altered in disease. This study investigates neural substrates of generalization from past experience in goal-oriented settings with a focus on the hippocampus and prefrontal cortex, two brain regions important for learning and memory and implicated in a range of psychiatric conditions.

PI_NAMEs: GUIDERA, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TITLE: Investigating neural substrates of generalization from past experience