ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: This project investigates genetic mechanisms that regulate hearing recovery after noise exposure in mice and humans. We focus on a transcription factor, FOXO3, that is crucial for outer hair cell survival and is implicated in human occupational hearing loss. Our goals are to discover how and where FOXO3 acts in the cochlea, using gain and loss of function methods, translatome sequencing, cell-specific knockouts, and by creating a novel mouse model for human hearing loss.

PI_NAMEs: WHITE, PATRICIA M. (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Ablation;Actin-Binding Protein;Actins;Address;Adult;Affect;Alleles;American;Animal Model;Apoptosis;Autophagocytosis;Binding;biological adaptation to stress;Biological Assay;Biological Markers;biomarker identification;Breeding;Caspase;Cell Death;Cell Survival;cell type;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;conditional knockout;CRISPR/Cas technology;Data;deaf;disability;disabled;Distress;DNA;Enterobacteria phage P1 Cre recombinase;experimental study;FOXO3A gene;Frequencies;gain of function;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;Goals;Grant;Hearing;hearing impairment;hearing preservation;Hearing Protection;Hearing Tests;Heat-Shock Proteins 70;Homeostasis;Hour;Human;Human Genetics;Individual;Induction of Apoptosis;Inner Hair Cells;Knock-out;Knockout Mice;Knowledge;Link;loss of function;LoxP-flanked allele;Measures;Methods;Modeling;Modification;mouse model;Mus;mutant;Neurons;Noise;noise exposure;Noise-Induced Hearing Loss;novel;Nuclear;Nucleic Acid Regulatory Sequences;Occupational;Occupational Noise;Ontology;Outer Hair Cells;overexpression;Oxidative Stress;Persons;Population;Predisposition;preservation;programs;protein expression;Proteins;rat Pres protein;recombinase;Recovery;response;Ribosomes;RiboTag;Risk;RNA;RNA analysis;Role;Single Nucleotide Polymorphism;sound;spiral ganglion;Stimulus;stress reduction;Supporting Cell;Technology;Testing;transcription factor;transcriptome sequencing;translatome;Validation;Variant;Wild Type Mouse;Work;Workplace

PROJECT_TITLE: Foxo3 Mechanisms in Noise Damage

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PI_NAMEs: WARD, TONY JOHN (contact)

PROJECT_TERMS: Behavior assessment;behavioral response;career;Centers for Population Health;Child;Child Health;Communities;Complement;County;Data;Data Collection;design;Development;economic evaluation;Economics;Education;educationally disadvantaged;Ensure;epidemiologic data;Epidemiology;Evaluation;experience;Face;frontier;Funding;Future;Geography;Grant;Health;health disparity;health economics;Health Promotion;improved;Intervention;Intervention Studies;Investments;Low income;Medically Underserved Area;Methods;Modeling;Montana;Outcome;Participant;Pathway interactions;Pattern;Persons;Phase;Prevention;Prevention Research;Process;programs;Publications;Qualitative Research;recruit;Research;Research Personnel;Research Project Grants;Reservations;Risk;Rural;rural area;Rural Community;Rural Health;rural setting;Structure;Surveys;theories;therapy design;training opportunity;underserved community;Vulnerable Populations

PROJECT_TITLE: Stakeholder Engagement and Intervention Support Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Two-thirds of Alzheimer's disease (AD) cases are female, and females with AD present at autopsy with more plaques and tangles than males of a comparable age. The goal of this project is to identify sex-specific genetic drivers of AD neuropathology and cognitive impairment. The identification of such genetic markers will facilitate the development of personalized interventions that are tailored to the sex and neuropathology of the individual.

PI_NAMEs: DUMITRESCU, LOGAN C (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Affect;Age;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;amyloid pathology;Amyloidosis;Autopsy;Biological;Biological Markers;Brain;Case/Control Studies;Cerebrospinal Fluid;Clinical;clinical diagnosis;Cognitive;Cognitive aging;cognitive change;Data;Data Set;Development;Diagnosis;Disease;Disparity;Disproportionately impacts women;effective intervention;endophenotype;Etiology;executive function;Female;Gene Expression;gene function;Generations;Genes;Genetic;genetic architecture;genetic association;Genetic Diseases;Genetic Markers;genetic risk factor;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;Genomics;Goals;hippocampal atrophy;human data;Impaired cognition;Individual;Inflammatory;Injury;innovation;International;Laboratories;Language;Late Onset Alzheimer Disease;Longitudinal Studies;male;Measures;Memory;men;multiple omics;Nerve Degeneration;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuropathology;novel;Outcome;Pathology;Pathway interactions;personalized intervention;personalized therapeutic;Persons;Population;Positron-Emission Tomography;precision medicine;Prevention;Process;Public Health;Research;Risk;Severities;sex;Sex Differences;Symptoms;tau Proteins;Tauopathies;therapeutic target;Time;Tissue-Specific Gene Expression;trait;United States;Validation;Variant;Visuospatial;Woman;women versus men;Work;X Chromosome

PROJECT_TITLE: Sex-Specific Genetic Drivers of Alzheimer's Disease Endophenotypes

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: Narrative This R35 proposal describes a broad and ambitious line of work that will produce groundbreaking and innovative studies to address significant gaps in our understanding of exercise and brain health in late adulthood. The aims target several major AD/ADRD milestones identified by NIH and will position junior scientists in leadership roles to advance the field forward in significant and pioneering ways.

PI_NAMEs: ERICKSON, KIRK I (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: active lifestyle;Address;Adoption;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Brain;brain health;cardiometabolism;cardiorespiratory fitness;Cognitive;Cognitive aging;cognitive function;data repository;Dedications;Dementia;Emotional;Exercise;exercise prescription;experience;follow-up;Genetic;Genotype;Impaired cognition;Incentives;Incidence;Individual;Individual Differences;individual variation;innovation;Knowledge;Leadership;Measurement;Measures;Mediating;Mentorship;Methods;Neurocognitive;Ocular orbit;Outcome;Participant;Persons;Physical activity;Physiological;Positioning Attribute;Predictive Factor;predictive modeling;prevent;Prevention;Public Health;racial disparity;randomized, clinical trials;Recommendation;Research Proposals;response;Role;Scientist;secondary analysis;Series;Sleep;United States National Institutes of Health;Work

PROJECT_TITLE: Physical Activity and Dementia: Mechanisms of Action


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Primary Health Care;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE A top TB control priority set by the World Health Organization is to “find the missing 3 million”- those 3 million individuals developing infectious TB each year but who are never diagnosed as having TB. Active TB case finding can reduce TB incidence by finding infectious cases before they present for care on their own, but is not widely adopted. We intend to inform the implementation and scale-up of an incentive-based strategy to identify TB from among close contacts of newly diagnosed cases; we will evaluate barriers to implementation, feasibility, acceptability and preliminary measures of effectiveness (yield).

PI_NAMEs: HANRAHAN, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Adopted;Assessment tool;Behavior;behavior change;behavior change wheel;Behavioral;career;Caring;case finding;Cessation of life;Clinic;comparative effectiveness trial;Contact Tracing;Country;Data;Decision Making;design;Detection;Diagnosis;Disease;Effectiveness;effectiveness measure;Elements;Enrollment;Epidemic;Epidemiology;Evaluation;experience;experimental study;Failure;financial incentive;Focus Groups;Future;global health;global health emergency;Goals;Health;Health Personnel;Health Priorities;Health system;Healthcare;Household;implementation barriers;implementation design;implementation facilitators;implementation measures;implementation science;implementation strategy;improved;Incentives;Incidence;indexing;Individual;Infrastructure;innovation;Interdisciplinary Study;Intervention;Interview;Investigation;Maps;Measures;meetings;Mentorship;Methodology;Methods;Modeling;Motivation;multidisciplinary;Newly Diagnosed;novel;Persons;pilot test;population health;primary care clinic;primary care setting;Process;Program Sustainability;programs;Province;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Resources;Rural;rural setting;rural South Africa;scale up;screening;skills;South Africa;success;Surveys;system-level barriers;Testing;Training;Tuberculosis;Tuberculosis diagnosis;Visit;World Health Organization

PROJECT_TITLE: Using an implementation science approach to refine, implement and evaluate pilot strategies for tuberculosis contact tracing in South Africa

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

PHR: This project is directly related to Center for Population Health Research priorities, as it explores a novel means of health promotion and prevention of age-related physical frailty, which is designed to overcome barriers to access and promote autonomy in managing physical health. Thus, it is well-suited to address the needs of under-served and rural communities.

PI_NAMEs: KITTELSON, ANDREW  (contact)

PROJECT_TERMS: Accounting;Address;Adopted;Adverse event;Age;age related;age related decline;Aging;Area;behavior change;behavioral economics;Blood Pressure;Cardiovascular Diseases;Centers for Population Health;Cessation of life;Chronic;Clinical assessments;Clinical Trials;clinically actionable;cohort;Cohort Studies;Communities;comparison control;Data;design;Development;Diabetes Mellitus;Diné Nation;efficacy evaluation;Equilibrium;Event;exercise program;Exposure to;falls;frailty;Fright;Future;Goals;Health;Health behavior;health care availability;health care settings;Health Promotion;Healthcare;Heart;Height;Home;Hospitalization;Human Resources;improved;Independent Living;insight;interest;Intervention;Interview;Investigation;Life;Light;literacy;Measurement;Methods;Modality;Monitor;novel;novel strategies;older adult;Outcome Measure;Participant;participant retention;Periodicals;Persons;Pharmaceutical Preparations;Phase;phase 1 study;physical conditioning;Physical Function;Physical therapy;Populations at Risk;Positioning Attribute;prevent;Prevention;Prevention program;Prevention strategy;Preventive;Preventive care;Primary Prevention;programs;Questionnaires;Randomized;randomized trial;Recording of previous events;Reporting;Research;Research Priority;response;retention rate;Risk;Rural Community;rurality;Safety;safety and feasibility;safety assessment;Schedule;Secondary Prevention;Site;Social isolation;Structure;Struthio camelus;Surveys;Telephone;Training;underserved community;United States National Institutes of Health;wellness visit;Work

PROJECT_TITLE: Cafe Move: A Novel Program for Prevention of Age-Related Physical Frailty


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Rural Health;Women's Health Research

PHR: In addition to being extremely common, PMADs are frequently undiagnosed and are negatively  associated with a broad range of negative outcomes. Of particular concern are findings that PMADs are  increasing. Rural populations are estimated to have PMADs rates that are more than double those in  non-rural areas and higher suicide rates.These negative MCH health outcomes are particularly prominent  in Montana. Research indicates that the use of doulas can improve a wide-range of pregnancy and

PI_NAMEs: LIDDELL, JESSICA  (contact)

PROJECT_TERMS: Address;Anxiety Disorders;Area;Centers for Population Health;Childbirth;Client;community based participatory research;Companions;Complication;Data;Emotional;experience;Family;Health;Health Care Visit;Healthcare;improved;indigenous community;Infant Health;intergenerational;Intervention;Interview;Investigational Therapies;Knowledge;marginalized population;Maternal and Child Health;Maternal Health;Mental Health;Mental Health Services;Methods;Modeling;Montana;Mood Disorders;Outcome;Participant;peer support;Perinatal;Personal Satisfaction;physical conditioning;postpartum health;Postpartum Period;Pregnancy;prenatal;Provider;Research;Rural Population;Self Efficacy;social;Structure;substance use;suicide rate;Testing;Training;Women's Health

PROJECT_TITLE: Addressing perinatal mood and anxiety disorders (PMADs) through a doula intervention


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: WALKER, ETHAN SHEPPARD (contact)

PROJECT_TERMS: Accounting;Acute;Address;Adult;adverse birth outcomes;Age;age related;Air;air cleaner;Air Pollution;ambient air pollution;Arrhythmia;Attitude;Behavior;Blood Pressure;Cardiovascular Diseases;Cardiovascular system;Centers for Population Health;Characteristics;Clinic Visits;cohort;Cohort Studies;Communities;community advisory board;Data;Data Set;design;Development;Devices;Diné Nation;Disease;Education;Effectiveness;efficacy evaluation;Electronics;Equilibrium;Evaluation;Event;Exposure to;Feedback;fine particles;follow-up;frailty;Future;Goals;Health;Health behavior;health care settings;Health Promotion;Heart;Height;High Prevalence;Home;Household;Human Resources;Implant;improved;Independent Living;Individual;indoor air;Indoor Air Pollution;Indoor Air Quality;Indoor environment;Infiltration;insight;interest;International;Intervention;intervention program;Interview;Investigation;Knowledge;Length;Literature;Measurement;Measures;member;Mental disorders;Modality;Modeling;Montana;mortality;novel;novel strategies;Outcome;Outcome Measure;Participant;Patient Recruitments;Patients;Perception;Persons;Pharmaceutical Preparations;physical conditioning;Physical Function;Population;portability;post intervention;Predisposition;prevent;Prevention;Prevention strategy;Program Development;Program Evaluation;programs;prospective;Public Health;Quality of life;randomized trial;Recommendation;Records;Reporting;Research;Research Priority;Respiratory Disease;Rural;Rural Community;Schedule;Seasons;sensor;Site;sociodemographics;Subgroup;Surveys;Target Populations;Testing;Theory of Change;Time;Training;underserved community;United States;United States National Institutes of Health;Universities;Visit;Wildfire;Work

PROJECT_TITLE: Wildfires and arrhythmias: evaluating associations and intervention strategies


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative This aim of this dissertation proposal is to investigate the effect of motor learning practice schedule on the acquisition, retention, and generalization of protective balance responses in individuals with Parkinson’s Disease. Positive findings will provide support for the development of balance rehabilitation protocols based on motor learning principles to mitigate falls in individuals with PD compared to age-matched controls. Since two- thirds of individuals with PD fall yearly, results of this research will have a broad impact on public health.

PI_NAMEs: AKINLOSOTU, RUTH YETUNDE (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Age;Agonist;antagonist;Anterior;Balance training;Characteristics;Clinical Trials;Development;Doctor of Philosophy;Equilibrium;fall injury;fall risk;falls;Fatal injury;flexibility;follow-up;Future;habituation;improved;Individual;Intervention;Learning;learning strategy;Measures;Methods;Motor;motor learning;Motor Skills;Muscle;Musculoskeletal Equilibrium;older adult;Parkinson Disease;Parkinsonian Disorders;Patients;Performance;Persons;pharmacologic;Population;Postural response;Posture;Process;Protocols documentation;Public Health;Recurrence;Rehabilitation therapy;Research;response;Schedule;skill acquisition;Symptoms;Testing;Touch sensation;Training;treadmill;Walking

PROJECT_TITLE: Motor learning of protective responses to balance perturbations in persons with Parkinson's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Physical Activity;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE In the U.S. two-thirds of young adults (18-24 years) pursue college, during which they adopt poor lifestyle behaviors which track into older age and contribute to cardiometabolic diseases (CMD). Sedentary behavior, particularly sitting, has been recognized by national and international agencies as a novel yet major risk factor, but one we know little about its effect on cardiometabolic diseases. Our overarching aim is to develop an evidence-based, multi-level intervention to reduce sedentary behavior and target the primary prevention of CMD in college-based young adults.

PI_NAMEs: HANSON, ERIK D (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Accelerometer;Adopted;Adult;Arterial Fatty Streak;Behavior;behavior prediction;Behavior Therapy;Biological Markers;Cardiometabolic Disease;cohort;college;Communities;Computers;Consultations;design;Development;Diet;Dietary Practices;Dimensions;disorder prevention;disorder risk;Evaluation;evidence base;experience;Factor Analysis;Food;food consumption;Future;General Population;Goals;Health;Health behavior;Hour;human old age (65+);implementation intervention;Individual;innovation;International;International Agencies;Intervention;intervention mapping;Leisures;Life Style;Lipids;Longitudinal, observational study;Maps;Measures;Mediating;Mediation;Modeling;multidisciplinary;novel;Occupational;older adult;Participant;Physical activity;Physical environment;Physiologic pulse;Population;Posture;Predictive Factor;Primary Prevention;Process;Protocols documentation;Public Health;Questionnaires;Recommendation;Recreation;recruit;Research;Risk Factors;sedentary lifestyle;Self Efficacy;sleep behavior;social norm;sociodemographic variables;Strenuous Exercise;substance use;Supination;Television;therapy design;Thigh structure;Transportation;tv watching;Visit;World Health Organization;Wrist;young adult

PROJECT_TITLE: Cardiometabolic Disease Prevention in College-based Young Adults: Mapping a Contextual Sedentary Behavior Intervention

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Infectious diseases are a growing threat to public health owing to increasing antimicrobial resistance and stagnation in new antibiotic development. Encouraged by our preliminary studies, we aim to develop a new class of dual-stimuli responsive antibiotic-loaded nanoparticles, which can effectively combat the global antimicrobial resistance crisis and offer a general, yet effective and safe solution to treat many types of bacterial infections.

PI_NAMEs: GONG, SHAOQIN - (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Affinity;Animal Model;Animals;Antibiotics;antimicrobial;Antimicrobial Resistance;Artificial nanoparticles;attributable mortality;Bacteria;Bacterial Infections;Binding;Biodistribution;biomaterial compatibility;Blood Circulation Time;Bypass;Catheters;Cell membrane;Cessation of life;Chemicals;Clinical;clinically relevant;combat;Communicable Diseases;cost;Cytosol;design;Development;Diabetes Mellitus;Disease;Dose Limiting;Drug Kinetics;drug resistance development;efflux pump;Electrostatics;Encapsulated;Engineering;Ensure;Escherichia coli;ESKAPE pathogens;Exhibits;extracellular;FDA approved;Formulation;Glutathione;Goals;human pathogen;Immune response;Immunologics;In Vitro;in vivo;Individual;Infection;Inflammatory;innovation;interest;Lectin;Left;Lung infections;Macrophage;Malignant Neoplasms;Mammalian Cell;Maximum Tolerated Dose;Membrane;methicillin resistant Staphylococcus aureus;Microbe;Microbial Biofilms;Modeling;Modification;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;nanoparticle;novel antibiotic class;pathogen;Penetration;Pharmaceutical Preparations;Pilot Projects;Polymers;Polysaccharides;Pseudomonas aeruginosa;Public Health;Rattus;Reactive Oxygen Species;Resistance;Shapes;Stimulus;synergism;systemic toxicity;Thigh structure;Tissues;Toxic effect;Treatment Efficacy;uptake;Venous

PROJECT_TITLE: Dual-Stimuli Responsive Antibiotic-Loaded Nanoparticles: A New Strategy to Overcome Antimicrobial Resistance

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Tumor recurrence and metastasis after primary therapy are the major causes of death in sarcoma patients. Metastatic tumor-targeted therapy is lacking. In this application, we will perform a novel class of T cell therapy for safely treating tumors.

PI_NAMEs: LI, SHULIN  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;Adverse effects;angiogenesis;anti-tumor immune response;arm;Autologous;Automobile Driving;Binding;cancer cell;Cause of Death;cell killing;Cell membrane;Cell surface;Cell Therapy;Cells;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;clinical application;Clinical Trials;cytokine;cytokine release syndrome;Cytotoxic Chemotherapy;Data;Diameter;Disease;Distant;effector T cell;efficacy evaluation;Extracellular Matrix;FOXP3 gene;gene product;Generations;Genes;Genetic Transcription;Grant;Hepatotoxicity;Homing;Human;humanized mouse;Immune;immune checkpoint;immune checkpoint blockade;Immunotherapy;improved;Injections;Interleukin-12;Interleukin-12 Gene;invention;Legal patent;Ligands;Lung;Lymphocyte;Malignant Neoplasms;Mediating;Memory;Metastatic Neoplasm to the Lung;Modeling;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;Osteosarcoma;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;pre-clinical;Prognosis;Proteins;receptor;Recurrence;Recurrent tumor;Regulatory T-Lymphocyte;Resistance;Risk;risk minimization;Risk Reduction;Safety;Sarcoma;Site;Soft tissue sarcoma;Surface;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Toxic effect;Translating;tumor;tumor eradication;tumor growth;Vimentin

PROJECT_TITLE: Gene-Product Auto-Targeting to Tumor Vessels

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Infectious Diseases;Liver Disease;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Metabolic diseases like obesity, diabetes, and metabolic syndrome, are thought to be heavily influenced by the composition of the microbiota and the over-accumulation ceramides, which are known to cause insulin resistance and fatty liver disease. We have identified a community of bacteria that improve metabolic health and decrease the ceramide pathway. The goal of this project is to understand which bacteria contribute to metabolic protection and decipher the unknown relationship between the microbiota and ceramides, which we believe will lead to novel therapeutics for the treatment of metabolic diseases.

PI_NAMEs: KLAG, KENDRA ALYSE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;Adipose tissue;Affect;Animals;Bacteria;Binding;Body Weight decreased;CD36 Antigens;CD36 gene;Ceramides;Chloroform;Classification;Clinical Research;Clostridium difficile;colonization resistance;Communities;Complex;Data;Defect;Deposition;Desulfovibrio;Diabetes Mellitus;Disease;enteric infection;epidemiology study;fasting glucose;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;fatty liver disease;Feces;Firmicutes;Food Hypersensitivity;gastrointestinal epithelium;Genes;Genome;Germ-Free;Glucose;Gnotobiotic;Goals;gut bacteria;gut colonization;gut inflammation;gut microbes;gut microbiota;Health;Health Benefit;High Fat Diet;host microbiota;Human;Immunoglobulin A;improved;In Vitro;in vivo;Individual;Inflammatory;Inflammatory Bowel Diseases;insight;Insulin Resistance;insulin sensitivity;Intake;Intestines;Knockout Mice;Laboratory Research;Lipids;Liver;Mediating;member;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic syndrome;Metabolism;metagenome;metagenomic sequencing;microbial;microbiota;microbiota composition;Molecular;Monitor;mouse model;neonate;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesogenic;pathogen;Pathogenesis;Pathway interactions;Population;prevent;Primary Cell Cultures;Probiotics;Production;Regulation;Research;response;Role;Small Intestines;Sphingolipids;Supplementation;Taxonomy;Testing;Therapeutic;Thinness;tool;underserved community;uptake;Weight Gain;Work

PROJECT_TITLE: Investigating Metabolically Protective Members of the Microbiota that Modulate Ceramides


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Caregiving Research;Clinical Research;Data Science;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The study is the first to explore whether automated speech processing can improve timely identification of home healthcare patients at risk for hospitalization and emergency department visits. In the future, our results can help nurses to identify patients who are deteriorating and to prioritize them for risk reduction interventions.

PI_NAMEs: HIRSCHBERG, JULIA B.;KOSTIC, ZORAN ;TOPAZ, MAXIM  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;Acoustics;Address;care episode;Care given by nurses;Caregiver support;Caring;Characteristics;Clinical;clinical care;clinically significant;Communication;Data;Data Science;Data Set;Data Sources;data streams;Databases;Dementia;Detection;Deterioration;Edema;Electronic Health Record;Emergency department visit;Engineering;Event;Family;feature selection;Formal caregiver;Frequencies;Future;Genetic Transcription;Goals;Health Care Research;Health Care Visit;Healthcare;Heart failure;Home Care Services;Home Health Care Agencies;Hospitalization;Hour;Human;improved;improved outcome;Intervention;Knowledge;lexical;Linguistics;Machine Learning;Measurement;medication nonadherence;Methods;model development;Modeling;Natural Language Processing;Nurses;older adult;Patient risk;Patients;Performance;prevent;Research;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Series;speech processing;Standardization;Suicide;System;Techniques;trend;United States;Variant;verbal;Voice;Work

PROJECT_TITLE: Using automated speech processing to improve identification of risk for hospitalizations and emergency department visits in home healthcare

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The disruption of spatial navigation and decision-making contributes to many neurological disorders, including Alzheimer’s disease. The proposed experiments will reveal fundamental aspects of how cortical regions interact and change over time to mediate spatial navigation and decision-making. By using new technologies and computational tools, our results are expected to reveal insights into neural circuit functions for decision- making in health and disease.

PI_NAMEs: HARVEY, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Alzheimer's Disease;Animals;Area;Behavior;Behavioral;Behavioral Model;Brain;Calcium;Cognitive;Communication;Communities;computerized tools;Computing Methodologies;Cues;Decision Making;Disease;Dorsal;experimental study;flexibility;Goals;Grant;Health;Image;imaging approach;Individual;insight;interest;Label;Learning;Link;Location;Mediating;Methods;Modeling;Motor;Mus;Nervous System Disorder;neural circuit;neuromechanism;Neurons;new technology;optogenetics;Output;Parietal;Parietal Lobe;Pattern;Performance;Phase;Population;Process;Property;Recurrence;Resolution;Rewards;Role;Sensory;Signal Transduction;Spatial Distribution;Testing;Time;tool;transmission process;Update;virtual reality;virtual reality environment;Visual;Visual Cortex;way finding;Work

PROJECT_TITLE: Parietal Cortex Networks for Sensorimotor Processing During Navigation

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Perianal fistulae are a complication of Crohn’s disease with poor treatment response that affects patients of African ancestry more frequently and with greater morbidity. These studies will explore differences in protein and gene expression between African and European ancestry patients with perianal fistula at the single cell level, and establish an in vitro rectal organoid model to characterize the lipid and cytokine mediators that contribute to fistula inception. The combination of these approaches will better define gene modules that distinguish perianal fistulizing Crohn’s disease between ancestry groups and inform the discovery of novel targets for the treatment of perianal fistula.

PI_NAMEs: LEVANTOVSKY, RACHEL  (contact)

PROJECT_TERMS: Adopted;Affect;African ancestry;Agonist;Air;Anal Fistula;ancestry analysis;Anus;Area;behavior influence;Biological Assay;Biopsy;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chronic inflammatory disease;Clinical;clinical care;Clinical Research;cohort;Cohort Studies;Colectomy;Collaborations;Colorectal;Complement;Complication;Crohn's disease;cytokine;Data;data acquisition;Data Set;Development;Dinoprostone;Disease;Disparate;Electrical Resistance;Environment;Epithelial Cells;epithelial injury;Epithelium;Epitopes;Etiology;European ancestry;Event;Excision;Fellowship;Fibrosis;Fistula;Fostering;Functional disorder;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genomics;Genotype;Goals;healing;Health;Home;IL17 gene;Immune;Immunofluorescence Immunologic;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;insight;interleukin-17C;Intervention;intestinal epithelium;Intestines;Lipids;Liquid substance;loss of function;Maintenance;Measures;Mediating;Mediator;Mesenchymal;Modeling;monolayer;Morbidity - disease rate;novel;Organoids;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Pattern;Penetration;Phenotype;Physiological;Play;Polymerase Chain Reaction;Population;power analysis;Predisposition;protein expression;Proteins;receptor;Receptor Inhibition;Recording of previous events;recruit;rectal mucosa;Rectum;Risk;risk variant;RNA;Role;Sampling;Signal Pathway;Signal Transduction;single cell genomics;single cell sequencing;single-cell RNA sequencing;Specimen;Stains;Stimulus;Stromal Cells;System;Tight Junctions;Time;Tissue-Specific Gene Expression;Tissues;TNF gene;Training;transcriptome;transcriptome sequencing;Translations;treatment response;validation studies;Variant;Visualization;WFDC2 gene;Work;wound;wound healing

PROJECT_TITLE: Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Human sight depends on rod and cone photoreceptors, specialized nerve cells that are easily harmed by inherited defects and normal aging. This research is important for public health because it will improve understanding of both healthy and diseased rods and cones, and may suggest strategies for patient counseling and sight preservation.

PI_NAMEs: GOLDBERG, ANDREW FX (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Address;Affect;Animal Model;Animals;Architecture;Basic Science;Biochemical;Biochemistry;Biogenesis;Biological Assay;Biophysics;Blindness;Cell Physiology;Cell Survival;Cellular biology;Cellular Structures;Clinical;Cone;cone-rod dystrophy;Counseling;Cultured Cells;Defect;design;Disease;disease phenotype;effective therapy;Electrons;Engineering;Etiology;Generations;Genetic;Genetic Models;Glutamic Acid;Goals;Health;Heterogeneity;Homologous Gene;Human;imaging approach;improved;In Situ;In Vitro;Individual;Inherited;inherited retinal degeneration;Knowledge;Light;Membrane;membrane activity;Membrane Proteins;Methods;microscopic imaging;Missense Mutation;Molecular;Molecular Genetics;molecular modeling;Morphogenesis;Mutation;Neurons;normal aging;Organelles;Pathogenicity;Patients;peripherin;Photoreceptors;preservation;protein structure;Proteins;Public Health;Recombinant Proteins;Regulation;Research;Retina;Retinal Cone;Retinal Diseases;Retinitis Pigmentosa;Rod;Role;scaffold;self assembly;Shapes;stem;Structure;Study models;Testing;Tissues;Vertebrate Photoreceptors;Vertebrates;Vision;Work

PROJECT_TITLE: Molecular Basis of Rod and Cone Photoreceptor Outer Segment Structures

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many neurological and psychiatric disorders are caused by mutations in splicing regulators or their targets in alternative splicing. However, we are unable to treat many of these diseases due to a lack of understanding of how these regulators shape the neuronal alternative splicing network. This project will provide one of the first integrated biochemical and genome-wide studies of a multi-subunit complex of splicing regulators found in the brain and can advance our understanding of the gene regulatory circuit underlying neurological and psychiatric disease.

PI_NAMEs: PEYDA, PARHAM  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Alternative Splicing;autism spectrum disorder;Binding;Binding Proteins;Binding Sites;Biochemical;Brain;Cells;Co-Immunoprecipitations;Code;cofactor;combinatorial;Complex;crosslink;Dependence;Disease;Epilepsy;Event;Exons;experimental study;Family;Genes;genetic regulatory protein;genome-wide analysis;Heterogeneous-Nuclear Ribonucleoprotein Group M;Heterogeneous-Nuclear Ribonucleoproteins;Hippocampus;hnRNP-H;Immunoprecipitation;Individual;Informatin;insight;Introns;knock-down;Knockout Mice;Maps;Mass Spectrum Analysis;Mental disorders;Methods;Mus;Mutate;Mutation;Nervous System Disorder;neuron component;neuron development;Neurons;novel;Nuclear RNA;nuclease;Pathway interactions;Play;Process;protein complex;Protein Family;Protein Splicing;Proteins;recruit;Regulation;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Sedimentation process;Shapes;Site;Transcript;transcriptome;transcriptome sequencing;Wild Type Mouse

PROJECT_TITLE: Regulation of Alternative Splicing in the Brain by a Large Assembly of Splicing Regulators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Aging;Dietary Supplements;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition

PHR: This research study will provide further insights into the fundamental roles of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) as unique photoreceptor-specific lipids required for the maintenance of retinal health, which could guide development of novel therapeutic interventions with synthetic VLC-PUFAs to correct retinal VLC-PUFA abnormalities encountered in age-related macular degeneration, STGD3, and other macular disorders. We expect that our newly developed organic synthetic protocols could be readily scaled up to facilitate these clinical studies.

PI_NAMEs: BERNSTEIN, PAUL STEVEN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acute;Age related macular degeneration;Animal Model;Animals;Attention;autosomal dominant mutation;autosome;biophysical properties;Biophysics;Bypass;Cell Culture Techniques;Cell membrane;Cell model;Chemistry;Chronic;Clinical Research;Collaborations;conditional knockout;Consumption;CRISPR/Cas technology;Data;Development;Diet;dietary;Dietary Fatty Acid;Disease;disorder of macula of retina;Dominant-Negative Mutation;Dryness;Environment;Exhibits;experimental study;Family;fatty acid metabolism;fatty acid supplementation;Fatty Acids;feeding;fluidity;Functional disorder;functional improvement;Health;Heterozygote;Human;Human body;human tissue;improved;insight;Knock-out;Lead;Lipid Chemistry;Lipids;macula;Macular degeneration;Maintenance;Membrane;Membrane Fluidity;membrane model;Methodology;Modeling;mouse model;Mus;Mutation;Neonatal;Nonexudative age-related macular degeneration;novel;novel strategies;novel therapeutic intervention;Oral Administration;Organism;Organoids;Patients;Permeability;Phenotype;photoreceptor disc;Photoreceptors;Polyunsaturated Fatty Acids;Process;protective effect;Proteins;Protocols documentation;Publishing;Reporting;Research;research study;response;Retina;Risk;Role;scale up;Scheme;Skin;Specialist;Stargardt's disease;Structural defect;Supplementation;Synaptic Transmission;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Universities;Utah;Variant;Vertebrate Photoreceptors;Very Long Chain Fatty Acid;visual motor;visual performance;Wild Type Mouse;Zebrafish

PROJECT_TITLE: Elucidating the Role of Very-long-chain Polyunsaturated Fatty Acids in Retinal Health and Disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Radiation Oncology;Rare Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RICE UNIVERSITY

PI_NAMEs: FULLER, CLIFTON DAVID;SCHAEFER, ANDREW J (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Adoption;advanced analytics;Affect;Aging;Algorithms;Anatomy;Area;base;Behavior;Cancer Control;cancer radiation therapy;Capital;chemoradiation;Clinical;Clinical Data;clinical implementation;Clinical Treatment;Communities;Community Hospitals;Complication;Computer software;connected health;cost;Coupled;Data;Data Set;Decision Making;Decision Support Systems;design;Development;Devices;Diagnosis;Dose;Economics;Emerging Technologies;Environment;Equipment;Evaluation;evidence base;Evolution;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Health;Health Policy;Health Technology;Healthcare;Human;Human Resources;Image;image guided radiation therapy;improved;in silico;Incentives;Individual;individual patient;individualized medicine;innovation;insight;Instruction;Insurance Carriers;Life;Linear Accelerator Radiotherapy Systems;low and middle-income countries;Magnetic Resonance Imaging;malignant mouth neoplasm;Malignant neoplasm of larynx;Malignant neoplasm of pharynx;Malignant Neoplasms;Medical Device;Medicare;Methodology;Methods;Modeling;models and simulation;Modernization;Monitor;Morbidity - disease rate;multidisciplinary;Neck Cancer;new technology;next generation;Normal tissue morphology;novel;Operations Research;Organ;Outcome;Overdose;Patient Care;Patient imaging;Patients;Physicians;Policies;Probability;Process;programs;Property;prototype;Provider;Radiation;Radiation therapy;radiation-induced injury;Regimen;Research;Resources;response;Risk;risk stratification;Schedule;Science;Self-Help Devices;Series;side effect;SMART health;soft tissue;Software Tools;standard care;Structure;support tools;Survivors;System;Systems Integration;Techniques;Technology;technology intervention;theories;Time;tool;Toxic effect;treatment planning;treatment response;treatment stratification;tumor;Tumor Volume;Uncertain Risk;Uncertainty;Validation;Variant;Work

PROJECT_TITLE: SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MOSS-V(50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Rare Diseases;Rural Health;Sickle Cell Disease;Social Determinants of Health;Telehealth

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Access to comprehensive pediatric sickle cell care continues to be a national concern, and is even a more pressing issue in rural and medically underserved areas. As telemedicine has been shown to be an effective means of providing care to pediatric populations living in rural and underserved areas, we propose to directly address barriers identified in previous work to the provision of comprehensive sickle cell care by adapting, refining, and piloting two telemedicine models (i.e., hub and spoke model and direct-to-consumer model). This research will not only expand access to comprehensive care for children with sickle cell disease, but our approach will help identify which telemedicine model is most appropriate for various environments, and we can easily adapt this approach for other subspecialty populations.

PI_NAMEs: JACOB, SEETHAL  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;adverse outcome;Affect;African American;Anxiety;Area;barrier to care;care coordination;career development;Caregivers;Caring;Child;Child Care;Childhood;Chronic;Chronic Disease;Clinical;clinical care;Communities;Comprehensive Health Care;Consultations;COVID-19 pandemic;Diabetes Mellitus;Disease;Disease Outcome;Education;effectiveness evaluation;Environment;Evaluation;evidence base;experience;extend lifespan;Faculty;Family;Funding;Genetic Counseling;Goals;Health;health care service utilization;Health Services;Healthcare;Hematological Disease;Hematologist;Hospitalization;hydroxyurea;implementation science;Improve Access;improved;Indiana;Information Technology;Inherited;Measures;Medical;medically underserved;Medically Underserved Area;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentorship;metropolitan;Modeling;Modernization;multidisciplinary;Newborn Infant;Outcome;pandemic disease;patient oriented;Patient-Focused Outcomes;Patients;pilot test;Population;Positioning Attribute;Preparation;Preventive therapy;Process;Provider;Psychosocial Assessment and Care;Quality of Care;Randomized, Controlled Trials;Reporting;Research;Research Methodology;Research Personnel;Research Proposals;Rural;rural area;rural underserved;satisfaction;scale up;Services;Sickle Cell;Sickle Cell Anemia;skills;Stress;Telemedicine;tertiary care;Time;Transportation;Travel;underserved area;underserved community;United States Agency for Healthcare Research and Quality;Wait Time;Work

PROJECT_TITLE: Telemedicine for Pediatric Sickle Cell Care in Medically Underserved Communities

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Infectious Diseases;Microbiome;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE As the human population shifts to a higher proportion of aged and geriatric individuals, it is critical that we develop interventional methods to maintain human health and to systemically treat age-related disease. Modifications of diversity in the human intestinal microbiome have been associated with chronic diseases including obesity, frailty, and cardiac dysfunction. Marmosets offer a unique model in which to evaluate the relationship between microbial diversity and age-related health changes, as well as to evaluate the efficacy of fecal microbiota transplant as an interventional treatment for aging.

PI_NAMEs: REVELES, KELLY RENEE;ROSS, CORINNA NICOLE (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Adverse effects;Age;age related;age related changes;age-related disease;aged;Aging;aging process;aging related;Alzheimer's Disease;Animal Model;Animals;Atherosclerosis;behavior measurement;Body Weight decreased;Callithrix;Callithrix jacchus jacchus;Caloric Restriction;Cardiovascular Diseases;Caring;Cell Aging;Chronic Disease;clinical investigation;Clostridium difficile;Complex;Dementia;Diabetes Mellitus;Diet;dietary;Dietary intake;Disease;Disease Progression;dysbiosis;Ecosystem;efficacy evaluation;Elderly;Epigenetic Process;Evaluation;exposed human population;Exposure to;extend lifespan;fecal transplantation;Firmicutes;frailty;Genetic;Genomics;Gnotobiotic;gut microbiome;gut microbiota;hallmarks of aging;Health;healthspan;high risk;Homeostasis;Human;Human Microbiome;Immune system;immunosenescence;improved;Incidence;Individual;Infection;Intervention;juvenile animal;life span;Life Style;Longevity;Maintenance;Malignant Neoplasms;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;Methods;microbial;microbial community;microbial disease;microbiome;microbiome alteration;microbiome research;microbiota;Modeling;Modification;mouse model;Mus;Myocardial dysfunction;Neurodegenerative Disorders;neuropsychiatry;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel therapeutics;Nutrient;obese person;Obesity;Onset of illness;Oral;Outcome;pathobiont;pathogen;Pharmacologic Substance;Physical activity;Physiology;pilot test;Play;Population;prevent;Prevention;Proteobacteria;Quality of life;Research;resilience;Resistance;Role;sarcopenia;Scientist;Sirolimus;Stress;Techniques;Therapeutic;Therapeutic Intervention;Thinness;Translations;Treatment Efficacy;Weight Gain

PROJECT_TITLE: Microbiome-mediated therapies for aging and healthspan in marmosets

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will seek fundamental knowledge regarding the reasons why the leading glomerular disease called focal segmental glomerulosclerosis progresses to a chronic kidney disease state.

PI_NAMEs: SHANKLAND, STUART JAMES (contact);WESSELY, OLIVER

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Actins;Acute;Address;Adult;alpha 2-Glucoproteins;Applications Grants;Biological Markers;CASP1 gene;Cell Count;cell injury;cell type;Cells;Chronic;Chronic Kidney Failure;Cicatrix;Cytoskeleton;Data;Data Analyses;design;Devices;Disease;Disease Outcome;Disease Progression;Disease remission;End stage renal failure;Endothelial Cells;Endothelium;Epithelial Cells;Event;Exhibits;Experimental Designs;Focal and Segmental Glomerulosclerosis;Functional disorder;gain of function;Genes;Genetic;genetic approach;glomerular endothelium;Glycocalyx;Goals;Grant;Health;Human;human data;improved;in silico;in vivo;Inflammasome;Inflammatory;injured;Injury;innovation;Knowledge;Ligands;Link;loss of function;Measures;Mediating;Mediator;Mesenchymal;Mus;Mutant Strains Mice;Neptune;novel therapeutic intervention;Outcome;overexpression;paracrine;Paracrine Communication;Parietal;Pathogenesis;Pathology;Patient-Focused Outcomes;Patients;Phenotype;Physiological;podocyte;prevent;Process;protein expression;Public Health;Publishing;receptor;Receptor Cell;Receptor Signaling;Renal glomerular disease;Research;Risk;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;single nucleus RNA-sequencing;slit diaphragm;Testing;theories;Therapeutic;therapeutic target;transcriptomics;Transgenic Mice;translational impact;Translations;Validation;Vascular Endothelial Growth Factors

PROJECT_TITLE: Targeting Podocyte-Endothelial Cell Crosstalk as a FSGS Therapy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chronic liver injury leads to fibrotic liver injury and cirrhosis, a condition without current therapy. Yap/Taz/Cyr61 activity during liver regeneration triggers fibrotic programs through common and divergent mechanisms, some of which could be modified to improve liver regeneration and overall health.

PI_NAMEs: YIMLAMAI, DEAN  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute;Address;Affect;arm;Behavior;Biochemical;Biochemical Pathway;Biochemistry;candidate validation;Cell Communication;Cell Proliferation;Cells;Characteristics;Chemicals;chemokine;chromatin immunoprecipitation;Chronic;chronic liver injury;Cirrhosis;Compensation;Complex;Data;Decision Making;Development;differential expression;Disparity;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Environment;Epithelial Cells;Epithelium;extracellular;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic approach;Genetic Transcription;genomic profiling;Genomics;Goals;Health;Hepatic Stellate Cell;Hepatocyte;high dimensionality;imaging approach;Immune;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;Liver;Liver Cirrhosis;Liver Fibrosis;liver inflammation;liver injury;Liver parenchyma;Liver Regeneration;Macrophage;Mediating;Medical;Modeling;monocyte;Myofibroblast;Natural regeneration;next generation sequencing;nonalcoholic steatohepatitis;Nonpenetrating Wounds;novel;Organ;Outcome;overexpression;paralogous gene;Pathway interactions;Phenotype;Play;programs;Publishing;receptor;recruit;Regenerative response;Reporting;Research Personnel;response;response to injury;Role;Signal Pathway;Signal Transduction;Structure;Therapeutic;tissue regeneration;Work

PROJECT_TITLE: Deciphering Epithelial Signals in the Liver to Drive Inflammation and Fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Hepatocellular carcinoma (HCC) is a highly fatal cancer accounting for over 780,000 deaths annually, and while men have consistently higher HCC risk and worse survival compared to women, we do not have an adequate understanding of why this disparity exists. We will apply a conceptual framework to three large multi- center patient cohorts to identify specific sex- (i.e. biologic) and gender-related (i.e. social, behavioral) factors that influence disparities in HCC incidence and prognosis. This proposal will yield critical data to inform future interventions to reduce disparities and improve survival for both men and women with HCC.

PI_NAMEs: RICH, NICOLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Accounting;Affect;Age;aged;Alcohol abuse;Androgens;Applications Grants;Articulation;Attitude;Award;Behavior;Behavioral;Biological;Biological Factors;California;Cancer Etiology;cancer health disparity;career;career development;caregiving;Caring;case control;Cause of Death;Cessation of life;Cirrhosis;Clinical;Clinical Data;clinical epidemiology;Clinical Research;cohort;Cohort Studies;coping;Data;data harmonization;Databases;Death Rate;Development;Development Plans;Diagnosis;Disparity;disparity reduction;Early Detection Research Network;Epidemiologist;Estrogens;Ethnic Origin;Ethnic Population;Etiology;experience;Funding;Future;Gender;gender disparity;Goals;Gonadal Steroid Hormones;Health;Health behavior;health care service utilization;Health Services;Household;improved;Incidence;Infrastructure;International;Intervention;Interview;Knowledge;Liver diseases;liver function;Malignant Neoplasms;men;Mentors;Mentorship;metabolic-associated fatty liver disease;Modeling;multi-ethnic;neoplasm registry;Nested Case-Control Study;Outcome;Pathogenesis;Patient Care;Patients;perceived stress;Population;Primary carcinoma of the liver cells;Prognosis;Prospective cohort;Prospective Studies;Public Health;Race;racial population;Reduce health disparities;Research;Research Methodology;Research Personnel;research study;Risk;Risk Factors;Role;Sampling;Scientist;secondary analysis;Serum;sex;sex disparity;skills;social;Social support;Strategic Planning;Structure;Surveys;survival disparity;Talents;Texas;therapy development;Time;Training;treatment adherence;Tumor stage;Underrepresented Populations;United States National Institutes of Health;Viral hepatitis;Woman;Women's Health;women's outcomes

PROJECT_TITLE: Determining the influence of sex and gender in hepatocellular carcinoma risk and survival

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: CINCINNATI

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The goal of this proposal is to develop sensors that will provide mechanistic insight into how non-neuronal cells, astrocytes, communicate in the brain in a region- and circuit-specific manner. This layer of information about functional astrocyte heterogeneity will contribute to the field by providing quantitative metrics to assess diversity. The new knowledge of how astrocytes communicate in the brain generated by our sensors can potentially lead to paradigm-shifting therapeutic approaches to neurological and developmental disorders.

PI_NAMEs: WHITE, RYAN J. (contact);XIAO, YI

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Affect;Affinity;Age;aptamer;Architecture;Astrocytes;Binding;Biological;Brain;brain dysfunction;Brain region;Cell surface;cell type;Cells;Chemicals;Chemistry;Collagen;Communication;Corpus striatum structure;design;Detection;Development;developmental disease;Diameter;Disease;DNA;Electrochemistry;Electrodes;Environment;Exocytosis;Frequencies;gamma-Aminobutyric Acid;Glutamates;Goals;Heterogeneity;Hippocampus;Homeostasis;Hot Spot;Immobilization;innovation;insight;Ionomycin;Knowledge;Left;Libraries;Maps;Measurement;Measures;meter;Molecular;Molecular Conformation;molecular dynamics;Monitor;nano;nanomolar;nanoscale;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuronal cell body;Neurons;neurovascular;Nucleic Acids;Organelles;Physiologic pulse;Physiological;Population;Process;Proteins;real time monitoring;Research;response;response to injury;Role;Science;sensor;Serine;Signal Transduction;spatiotemporal;Specificity;Structure;Surface;synaptic function;System;Techniques;Technology;technology development;temporal measurement;Testing;Therapeutic;three dimensional cell culture;Time;Tissues;tool;Transcriptional Regulation;transmission process

PROJECT_TITLE: Developing Electrochemical Sensors to Enable Quantitative Measure of Gliotransmitter Release from Astrocytes

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Prevention;Transplantation

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE Corneal transplantation is the most commonly performed type of solid organ transplantation in the world and T cell-mediated alloimmune rejection is the most common cause of corneal transplant failure. We have recently demonstrated fibrosis in rejected corneal transplants, and in the proposed research we will investigate the interactions between T cell alloimmunity and fibrosis in corneal transplantation. These studies will provide fundamental insights in a previously unexplored area and have the potential to help identify novel therapeutic strategies for i) preventing transplant fibrosis and failure and ii) regulating T cell-mediated immune rejection.

PI_NAMEs: DOHLMAN, THOMAS  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Advisory Committees;Apoptosis;Applications Grants;Area;Basic Science;career;career development;Cell Physiology;Cell Survival;Cells;Clinical;Coculture Techniques;Cornea;corneal scar;Data;Development;Dinoprostone;Ear;Effector Cell;effector T cell;Environment;experience;Extracellular Matrix;Eye;Failure;Fibrosis;Fostering;Foundations;Functional disorder;Funding;Goals;graft failure;Graft Rejection;Homeostasis;Immune;Immunity;Immunology;immunoregulation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory milieu;insight;Institution;interest;Interferon Type II;Investigation;isoimmunity;Keratoplasty;Laboratories;Ligands;Massachusetts;Mediating;medical schools;Mentors;Mentorship;Modeling;Myofibroblast;novel;novel strategies;novel therapeutic intervention;Ophthalmology;Organ Transplantation;Patients;PF4 Gene;Play;prevent;Prevention;Prevention strategy;Process;Production;Program Development;receptor;repaired;Research;research and development;Research Institute;Research Personnel;Research Proposals;Resolution;Resources;response;response to injury;Role;Scientist;Solid;Structure;success;System;T cell regulation;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Th1 Cells;therapeutic target;Tissues;TNF gene;Training;Training Programs;Transforming Growth Factor beta;Translating;translational potential;transplant model;Transplantation;Transplantation Immunology;Tumor Necrosis Factor-Beta;United States National Institutes of Health;Work

PROJECT_TITLE: The Fibrosis-Immunity Interface in Corneal Transplantation


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative CD4+ T cell help is required for optimal effector CD8+ T cell function; however, therapies that enlist CD4+ T cells for cancer immunotherapy are lacking. I discovered that intratumor activation of childhood vaccine CD4+ T cell recall responses inflame the tumor microenvironment and mediate antitumor efficacy. This work will define inflammatory reprogramming, CD8+ T cell potentiating, and `helper' functions induced by CD4+ T cell recall within tumors to leverage CD4+ T cells for cancer immunotherapy.

PI_NAMEs: BROWN, MICHAEL CLAVON (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: adaptive immunity;Aftercare;Agonist;Antibodies;Antigen-Presenting Cells;Antigens;antitumor effect;Autologous;Bilateral;Biological Assay;Biometry;Brain Neoplasms;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Capsid;CD14 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Density;Cell Physiology;Cell Separation;cell type;Cells;Chemosensitization;Childhood;Clinical;clinical translation;clinically actionable;Communicable Diseases;Complement;cytokine;Cytolysis;Data;Dendritic Cells;design;differential expression;draining lymph node;Fatty acid glycerol esters;Flow Cytometry;Gene set enrichment analysis;Glioblastoma;Glioma;Goals;granulocyte;Human;Immune response;Immune system;Immunity;Immunization;Immunize;Immunobiology;immunogenic;Immunologic Stimulation;Immunologic Surveillance;Immunotherapy;Infiltration;Inflammation;Inflammatory;Injections;Ligation;Macrophage;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Melanoma;Melanoma Tumor;Memory;Mentors;Modeling;Molecular Target;Monitor;Mus;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;Natural Killer Cells;neoplasm immunotherapy;neoplastic cell;novel;novel therapeutics;Oncolytic poliovirus;Ovum;pathogen;Pathway interactions;Patients;Pattern recognition receptor;Phase;Phenotype;Play;Poliomyelitis;Poliovirus Vaccines;Poly I-C;Postdoctoral Fellow;Principal Component Analysis;programs;PTPRC gene;Public Health;Qi;Recurrence;Research;response;Role;Route;SILV gene;Slice;STING agonists;subcutaneous;success;synergism;T-Lymphocyte;targeted cancer therapy;Testing;Tetanus;Tetanus Helper Peptide;Tetanus Toxoid;Tetanus Vaccine;Therapeutic;TNFRSF5 gene;transcriptome;transcriptome sequencing;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Vaccinated;Vaccination;Vaccines;Virotherapy;Work

PROJECT_TITLE: Reviving cancer immune surveillance with CD4 T cell help

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: ORTHOPEDICS

ORG_NAME: STANFORD UNIVERSITY

PHR: The proposed work will fill in the critical gap of knowledge on the divergent immune response to macroporous scaffolds with tunable biomaterial compositions. Our findings will guide novel biomaterials-based therapies to treat critical-size cranial bone defects through novel immunomodulation strategies.

PI_NAMEs: YANG, FAN  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Adopted;Animal Model;Award;Biochemical;Biocompatible Materials;Biological Process;Biology;biomaterial interface;bioscaffold;bone;Bone Diseases;bone fracture repair;bone healing;Bone Injury;Bone Regeneration;Bone remodeling;bone repair;Bone Tissue;CD8-Positive T-Lymphocytes;cell type;Cells;Cephalic;Chronic;Coculture Techniques;Cytometry;Defect;design;early onset;extracellular;Extracellular Matrix;first responder;Fracture;Gelatin;Goals;Growth Factor;Guanine Nucleotide Exchange Factors;Helper-Inducer T-Lymphocyte;high dimensionality;Human;Hydrogels;Immune;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunology;immunoregulation;Implant;In Vitro;in vitro Model;in vivo;in vivo regeneration;Individual;Inflammation;Inflammatory;injured;Injury;journal article;Knowledge;Letters;Literature;long bone;Macrophage;mechanical signal;Mediating;Mesenchymal Differentiation;Mesenchymal Stem Cells;Methods;migration;Modeling;Mus;Nanoporous;novel;novel therapeutics;Osteoblasts;Osteogenesis;osteogenic;Paracrine Communication;Peer Review;Phase;Phenotype;Polymers;porous hydrogel;Progress Reports;Publications;Publishing;recruit;regenerative;Reporting;Research;Role;scaffold;Scientist;single cell analysis;single cell sequencing;single-cell RNA sequencing;Site;soft tissue;stem cell differentiation;stem cells;T cell response;T-Lymphocyte;Testing;Tissue Engineering;tissue regeneration;Transplantation;trend;Work

PROJECT_TITLE: Microribbon scaffold-mediated Immunomodulation for Cranial Bone Repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Climate change is expected to have important negative consequences for the health and living standards of vulnerable populations in low and middle-income countries, but to date there are few population-based strategies that have been documented to help protect against these exposures. We will use data from randomized controlled trials of cash transfers to poor households in Zambia and Kenya to test whether these additional resources can protect food security, child health and youth lifecourse transitions during periods of adverse climate conditions.

PI_NAMEs: GRAY, CLARK  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;African;Age;Agriculture;Body mass index;boys;case finding;Child;Child Health;Climate;climate change;climate-related exposures;Collaborations;Communities;coping;Country;Data;Data Set;Data Sources;dietary;Disasters;Droughts;Employment;Evaluation;Event;Expenditure;experience;Family;Fertility;Floods;follow-up;Food;food protection;food security;Future;Gender;Geography;girls;Grant;Health;health care service utilization;Height;Heterogeneity;High temperature of physical object;Household;human old age (65+);improved;Intervention;Kenya;Latin American;Life Cycle Stages;Link;Literature;Living Standards;low and middle-income countries;marginalized population;Marriage;Measures;migration;Orphan;Outcome;Patient Self-Report;Personal Satisfaction;Policies;Population;population based;population health;Precipitation;Productivity;Program Evaluation;programs;Rain;Randomized;Randomized, Controlled Trials;Research;Resolution;Resources;response;Risk;Schools;Scientist;Shock;Surveys;Temperature;Testing;Time;Vulnerable Populations;Weight;welfare;Youth;Zambia

PROJECT_TITLE: Family resources, food security, and child health during periods of temperature change and adverse climate conditions

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Microbiome;Rare Diseases

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: NARRATIVE While historically infections have been attributed to individual pathogens, polymicrobial communities are now known to be common in human disease and can be composed of multiples species of bacterial, viral, and fungal origin. Interactions between differing microbial species can profoundly alter the course of human disease; however, how bacteria sense signals from other bacterial species, the nature of these signals, and how signaling contributes to community behaviors necessary for human infection are unknown. This proposal seeks to answer these questions by integrating genetic approaches with state-of-the-art live-imaging of bacterial behaviors during mixed species cultivations and 3D imaging of bacterial communities in the lungs and respiratory secretions of patients with polymicrobial infections.

PI_NAMEs: LIMOLI, DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Animal Model;Antibiotic Therapy;appendage;Bacteria;bacterial community;Behavior;Cells;Cessation of life;chronic wound;Communication;Communities;cystic fibrosis infection;cystic fibrosis patients;Data;design;Disease;Distant;Environment;Exposure to;Fluorescent in Situ Hybridization;Gastrointestinal tract structure;Gene Expression;Genes;genetic approach;Health;high throughput screening;Human;Human body;human disease;Image;Imaging Techniques;In Situ;Individual;Infection;interspecies communication;Laboratories;Language;Lung;Lung infections;Lung Transplantation;member;Microbe;microbial;microbial community;Motility;Movement;Nature;next generation;opportunistic pathogen;Organ;Organism;pathogen;Pathway interactions;Patients;Poison;Positioning Attribute;Pseudomonas aeruginosa;Reporting;respiratory;Signal Transduction;Signaling Molecule;social;Structure;System;Three-Dimensional Imaging;Tissues;Viral;Virulence;Visualization;Wound Infection

PROJECT_TITLE: Decoding interspecies signaling networks and the biogeography of polymicrobial infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Although NMD is the only RNA regulatory pathway that has been linked to numerous mental illnesses, a comprehensive model of how cell-specific NMD influences synaptic and cognitive function remains elusive. Astrocyte dysfunction has been implicated in the pathophysiology of numerous neurological disorders, with a strong impact on synaptic plasticity and behavior. This research proposal is designed to elucidate the astrocytic mechanisms that regulate synaptic plasticity through mRNA degradation, and will illuminate an important molecular mechanism with likely relevance to a broad range of neurodevelopmental disorders.

PI_NAMEs: COLAK, DILEK  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Ablation;Acute;Adult;Animals;Astrocytes;Behavior;behavior influence;Behavioral;Behavioral Assay;behavioral impairment;behavioral phenotyping;Bioinformatics;Biological Assay;Biological Process;Brain;Brain Diseases;Categories;Cell model;cell type;Cells;Coculture Techniques;Cognition;cognitive function;cognitive performance;crosslinking and immunoprecipitation sequencing;Dendrites;design;Detection;Disease;Electrophysiology (science);Ensure;Equilibrium;Excision;experimental study;Extracellular Space;Functional disorder;Functional impairment;Genes;Genetic;Glutamates;Goals;High-Throughput Nucleotide Sequencing;Hippocampus;Image;Impaired cognition;Impairment;in vitro activity;in vivo;insight;Knockout Mice;Knowledge;Label;Learning;Link;Literature;Long-Term Potentiation;Marble;Measures;Mediating;Memory;Memory impairment;Mental disorders;Messenger RNA;Modeling;Molecular;morris water maze;mouse model;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;multi-electrode arrays;Mus;Mutant Strains Mice;Nervous System Disorder;Neurocognitive;neurocognitive disorder;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropsychiatric disorder;new therapeutic target;Ontology;Pathway interactions;Phenotype;Process;Protein Biosynthesis;Publishing;Regulation;Regulatory Pathway;Reporting;Research;Research Proposals;RNA;RNA Degradation;Role;Signal Transduction;Slice;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Tamoxifen;Techniques;Testing;Time;Tissues;Transcript;transcriptome sequencing;Translating;two photon microscopy;two-photon;Viral;Work

PROJECT_TITLE: Astrocyte RNA degradation and cognitive function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE TRPV6 and TRPV5 are Ca2+ selective epithelial ion channels. Loss of function mutations in these channels are associated with chronic pancreatitis and kidney stones. This project studies the regulation of these channel by endogenous calmodulin and phosphatidylinositol 4,5-bisphosphate, and take advantage of our molecular level understanding of their regulation to identify small molecules that increase channel activity, which could be potentially used to treat pancreatitis and kidney stones.

PI_NAMEs: CARNEVALE, VINCENZO ;ROHACS, TIBOR  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acinus organ component;Acyl Coenzyme A;Binding;Binding Sites;Calmodulin;capsaicin receptor;Charge;chronic pancreatitis;clinical application;Computational Biology;Cryoelectron Microscopy;Development;Docking;Duct (organ) structure;Electrophysiology (science);Enzyme Activation;Enzymes;Epithelium;Equilibrium;Excision;experimental study;Fluorescence;fluorescence imaging;Funding;Future;Goals;Homology Modeling;insight;Ion Channel;Kidney;Kidney Calculi;Ligands;Lipids;Liquid substance;Lobe;loss of function mutation;Maps;Measurement;Mediating;Membrane;Molecular;molecular dynamics;Mutate;Mutation;Mutation Analysis;novel therapeutic intervention;Pancreas;Pancreatitis;Phosphatidylinositols;Phospholipids;Positioning Attribute;premature;prevent;prototype;Regulation;Role;Site;Site-Directed Mutagenesis;small molecule;Specificity;structural biology;Structure;Surface;Testing;Urine;Work

PROJECT_TITLE: Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stroke;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Poor neurodevelopmental outcomes remain stubbornly prevalent after pediatric critical illness despite medical and surgical advances that have produced improved survival for conditions such as stroke, congenital heart disease, hypoxic-ischemic encephalopathy, and extreme prematurity. To develop effective interventions, a bedside neuroimaging system capable of timely detection of injury during longitudinal monitoring is needed, and optical neuroimaging of the brain’s resting-state holds potential to fill this role. In this application, I propose to develop statistical methods and biomarkers of neurologic injury applicable to bedside translation using mouse models of acute and chronic hypoxemia and optical intrinsic signal imaging of resting-state hemodynamics. Page 1

PI_NAMEs: WHITE, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;acute stroke;Adult;Affect;Algorithms;Animal Disease Models;Anxiety;Architecture;Area;behavior test;bench to bedside;Biological Markers;biomarker development;Board Certification;Brain;Brain Mapping;career;Childhood;Chronic;Clinical;clinical care;clinical examination;clinical heterogeneity;Clinical Research;Communities;Complex;congenital heart abnormality;cost;Critical Care;Critical Illness;Critically ill children;Cyanotic heart disease;Data;Detection;Development;Diagnosis;Diffusion;Disease;Doctor of Philosophy;effective intervention;Environment;extreme prematurity;Faculty;fetal;Frequencies;Functional Magnetic Resonance Imaging;Funding;Future;Goals;hemodynamics;Histologic;Histology;Hospitals;Hour;Human;Hypoxemia;Hypoxia;Hypoxic Brain Damage;Image;Image Analysis;image registration;imaging biomarker;Impairment;improved;improved outcome;Infarction;Injury;Intensive Care Units;Intervention;Ischemia;Ischemic Stroke;K-Series Research Career Programs;Knowledge;Learning;Life;Link;Location;Longitudinal Studies;Magnetic Resonance Imaging;Managed Care;Measures;Medical;Mentors;Mentorship;Methods;middle cerebral artery;Modeling;Molecular;Monitor;mouse development;mouse genetics;mouse model;Mus;Neonatal;neonatal hypoxic-ischemic brain injury;neonatal injury;neonate;Nervous System Disorder;Nervous System Trauma;neuroimaging;neuroimaging marker;Neurologic;Neurons;Noise;normoxia;novel;novel therapeutics;Onset of illness;Operative Surgical Procedures;optical imaging;Optical Methods;Optics;Outcome;Pathway Analysis;Patients;pediatric cardiologist;pediatric patients;Pediatric Research;Perfusion;Phase;Physicians;Population;portability;Positioning Attribute;post stroke;preclinical development;Reperfusion Therapy;Reproducibility;Research;Rest;Role;Sampling;Scientist;serial imaging;Severities;Severity of illness;Signal Transduction;skills;Source;Statistical Data Interpretation;Statistical Methods;statistics;Stroke;success;Survival Rate;System;Techniques;tenure track;Testing;Therapeutic Intervention;Tissue Viability;Tissues;tool;Training;Translating;translational study;Translations;trend;ultrasound;Variant;white matter;Work

PROJECT_TITLE: Optical Functional Neuroimaging of Acute and Chronic Hypoxia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The transcription factor ZFP24, which is regulated by phosphorylation, binds to the genome in proximity to genes that are crucial for oligodendrocyte differentiation and CNS myelination and this binding activates gene expression. We propose here to identify the kinases and phosphatases that control ZFP24 phosphorylation, to characterize ZFP24 phosphorylation intermediates in oligodendrocyte lineage cells, and to determine the role of ZFP24 in adulthood. These studies have the potential to identify therapeutic strategies to enhance myelination and remyelination through the modulation of ZFP24 kinase activity.

PI_NAMEs: ELBAZ-EILON, BENAYAHU  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Affect;Axon;Binding;C2H2 Zinc Finger;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Consensus;Crosslinker;Custom;Demyelinations;Development;DNA Binding;DNA Microarray Chip;DNA Sequence;Enzymes;Event;Failure;functional status;Gene Expression;Genes;Genetic Models;Genetic Transcription;Genome;Half-Life;inducible gene expression;Maintenance;mature animal;Modeling;mouse model;Multiple Sclerosis Lesions;multiple sclerosis patient;mutant;Mutant Strains Mice;Myelin;myelination;Nucleic Acid Regulatory Sequences;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Phenocopy;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Process;programs;Protein Dephosphorylation;Protein Isoforms;Proteins;remyelination;Role;screening;stem cell differentiation;stem cells;Testing;Therapeutic;therapeutic target;Transcript;transcription factor;Zinc;Zinc Fingers

PROJECT_TITLE: ZFP24 Control of the myelination program of oligodendrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Genome-wide association studies of human disease provide a powerful opportunity to uncover novel etiologies and inform rational drug targets which would otherwise be overlooked. The goal of this project is to elucidate the mechanism whereby a genetic variant in CD33 protects individuals from Alzheimer’s Disease, which may provide a breakthrough in this devastating disease with no effective treatment options and improve the quality of life for millions of patients. This project will provide exceptional training to an underrepresented and highly motivated doctoral candidate, facilitating his transition to postdoctoral studies and launching his promising career as an independent neuroscience researcher.

PI_NAMEs: SHAW, BENJAMIN C. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: abeta toxicity;Address;Affect;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Animal Model;Antigen-Antibody Complex;autosome;Award;Big Data;Biological Assay;Brain;brain cell;career;Caring;Cell Culture Techniques;Cell Line;Cell surface;Cell Surface Receptors;Cells;Cellular biology;Clinical;Clinical Trials;Co-Immunoprecipitations;Communication;Complex;confocal imaging;Confocal Microscopy;CRISPR/Cas technology;Data;Data Analyses;data mining;Development;Disease;Dose;Drug Targeting;druggable target;Educational workshop;effective therapy;Electronic Health Record;Engineering;Enzyme-Linked Immunosorbent Assay;Etiology;Exons;experience;experimental study;Faculty;Functional disorder;Future;gain of function;Gene Chips;Gene Expression;Genetic;genetic risk factor;Genetic Techniques;genetic variant;genome editing;genome wide association study;glial activation;Goals;graduate school;graduate student;Heritability;Human;human data;human disease;human subject;Human Subject Research;human tissue;hyperphosphorylated tau;Immune;Immunoassay;immunoregulation;Impairment;improved;In Situ;In Vitro;Individual;induced pluripotent stem cell;inhibitor;insight;Institution;Knowledge;Learning;Ligand Binding Domain;Manuscripts;Measures;meetings;Mentors;Mentorship;Microglia;Microscopy;Modeling;Molecular and Cellular Biology;Molecular Biology;Molecular Genetics;monocyte;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Myelogenous;nano-string;Neurodegenerative Disorders;neuroimmunologic disease;Neurosciences;neurotoxicity;new therapeutic target;next generation;novel;Oral;overexpression;Pathology;Patients;Peptides;Phagocytosis;pharmacologic;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Pluripotent Stem Cells;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;PTPN6 gene;Quality of life;receptor;Refractory Disease;Research;research clinical testing;Research Personnel;Resolution;Risk Factors;RNA Splicing;Role;sample collection;Sampling;Scientist;Signal Transduction;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;skills;Small Interfering RNA;Societies;symposium;System;tau Proteins;Technical Expertise;Techniques;Technology;tenure track;Therapeutic;therapeutic target;Time;Tissue Sample;Training;Transfection;Translating;TREM2 gene;Tyrosine;undergraduate student;Variant;Viral;Western Blotting;Work;Writing

PROJECT_TITLE: Translating Genetic Risk Factors to Therapies: From Big Data to Druggable Targets


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Up to 37% of conceptions fail to advance beyond 20 weeks of gestation because the embryo fails to implant into the uterus. This project tests a new idea that alternative mRNA splicing mediated by sex-steroid hormones is critical for normal function of the uterus. This project will identify novel transcript variants that are associated with uterine function and may lead, in the long term, to new strategies to diagnose or prevent early pregnancy loss.

PI_NAMEs: KOMMAGANI, RAMAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Alternative Splicing;Area;Basic Science;Biochemical;Biological Assay;Biological Factors;Biopsy;blastocyst;Cell Differentiation process;Cell Proliferation;cell type;Cells;Chromatin;chromatin immunoprecipitation;Conceptions;conditional knockout;Data;data integration;Decidual Cell;Decidual Cell Reactions;Diagnosis;early pregnancy loss;Embryo;Endometrial;Endometrial Stromal Cell;Endometrium;Epithelium;Estrogens;failure Implantation;Genes;Genomics;Gonadal Steroid Hormones;Homologous Gene;Hormones;Human;human tissue;Impairment;Implant;implantation;In Vitro;in vivo;inhibitor;insight;knock-down;Knockout Mice;Knowledge;Lead;LoxP-flanked allele;Measures;Mediating;Messenger RNA;Molecular;Monitor;Mus;National Institute of Child Health and Human Development;natural Blastocyst Implantation;non-genomic;novel;Pathway interactions;Physiology;Post-Transcriptional Regulation;Pregnancy;Pregnancy loss;prevent;Process;Progesterone;Progesterone Receptors;Proliferating;Proteins;Recurrence;response;Reverse Transcriptase Polymerase Chain Reaction;RNA Splicing;Role;Small Interfering RNA;Spontaneous abortion;steroid hormone;Strategic Planning;Stromal Cells;Testing;Transcript;transcriptome sequencing;Ubiquitin;uterine receptivity;Uterus;Variant;Woman;Work

PROJECT_TITLE: Post-Transcriptional Regulation of Embryo Implantation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Narrative Sleep disorders are associated with cognitive dysfunction, mood disorders and mental illness. Some sleep problems may be caused by abnormalities in `sleep homeostasis; a process that increases the need for sleep. The cellular mechanisms governing sleep homeostasis are unknown, but may involve glial astrocytes. Identifying the role of these cells in sleep will provide new insights into the cellular basis of sleepiness.

PI_NAMEs: FRANK, MARCOS G (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Anatomy;Arousal;Astrocytes;Attention;awake;basal forebrain;Biological;Brain;brain cell;Cells;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Coupled;Cyclic AMP;Data;designer receptors exclusively activated by designer drugs;Development;differential expression;digital;Drowsiness;Drug Targeting;Electroencephalography;Equilibrium;Etiology;Excessive Daytime Sleepiness;Exocytosis;experimental study;Feedback;frontal lobe;G alpha q Protein;Gene Expression;Gene Expression Profiling;Glial Fibrillary Acidic Protein;Glutamate Transporter;GTP-Binding Proteins;Heterogeneity;Homeostasis;Image;Impaired cognition;In Situ Hybridization;in vivo;innovation;insight;Ion Channel;Learning;Ligands;Measurement;Measures;mechanical signal;Mediating;Memory;Mental disorders;Metabolic;Metabolism;Methods;Microscopy;miniaturize;Molecular;Mood Disorders;Morbidity - disease rate;Morphology;Mus;Nervous System Disorder;Neuroglia;Neurons;neurotransmitter uptake;Neurotransmitters;new therapeutic target;next generation sequencing;novel;Pathway interactions;Phospholipase C;Play;Polysomnography;Process;promoter;Proteins;REM Sleep;response;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Sleep;sleep abnormalities;Sleep Deprivation;Sleep Disorders;Sleeplessness;STIM1 gene;Synapses;Techniques;Technology;Testing;Time;Transcript;transcriptome;two photon microscopy;two-photon;United States;Wakefulness

PROJECT_TITLE: Astroglial mechanisms in sleep homeostasis

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE The environmental health problems faced by the nation are multi-factorial in nature, and therefore require multi-disciplinary approaches for effective intervention. Our training program emphasizes the importance of multidisciplinary training and translation of basic science findings to obtain rigorous, reproducible and transparent results that benefit the patient and/or community. This multi-disciplinary translational program interfaces with the NIH Roadmap and the NIEHS strategic plan.

PI_NAMEs: HEIN, DAVID W;WISE, JOHN PIERCE (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Training Programs

PROJECT_TITLE: UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative Genomics is a major driving force for modern biomedical research. Given the recent advances in genomic technologies and electronic health records, analysis and interpretation are the biggest bottlenecks to understanding the basis of human variation and disease. This training program will produce a diverse generation of computational genomicists with the statistics, computer science, bioinformatics, molecular biology, and genetics skills necessary to turn this flood of data into biomedical knowledge that can advance the understanding, diagnosis, and treatment of disease.

PI_NAMEs: ARBOLEDA, VALERIE A (contact);PIMENTEL, HAROLD

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Genomics;Grant;Training

PROJECT_TITLE: Training Grant in Genomic Analysis and Interpretation


NIH_SPENDING_CATS: Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Neuroblastoma is a fast-growing cancer that affects infants and children. Our work is designed to exploit an important new Achilles’ heel of this disease. Because drugs that exploit a specific weakness of cancer are less toxic than standard chemotherapy, our research may help deliver therapies that are more effective and less toxic than current approaches.

PI_NAMEs: HODGES, HAMILTON COURTNEY (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: 3-Dimensional;addiction;advanced disease;Affect;Animal Model;Apoptosis;ATP phosphohydrolase;Body Weight;Cell Culture Techniques;Cell Cycle;Cell Cycle Deregulation;Cell Cycle Progression;Cell Death;Cell Death Induction;Cell Proliferation;Cells;Cessation of life;chemotherapy;Child;Childhood Solid Neoplasm;Clinical;Clinical Trials;Combined Modality Therapy;Complex;Conflict (Psychology);counterscreen;Cytogenetics;Data;Dependence;design;Development;Diagnosis;Disease;DNA;DNA Damage;DNA fiber assay;DNA replication fork;Drug Combinations;effective therapy;Excision;Gamma-H2AX;Gene Amplification;Genetic Transcription;hearing impairment;high risk;Human;Immunocompetent;Impairment;improved;In Vitro;in vivo;Infant;inhibitor;Kinetics;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Measures;Modeling;mouse model;Mus;MYCN gene;nerve damage;Neural Crest;Neural Crest Cell;Neuroblastoma;neuroblastoma cell;Neurons;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;Output;Pathway interactions;Patients;pediatric patients;Peripheral;Pharmaceutical Preparations;Play;pre-clinical;programs;Progression-Free Survivals;Proliferating;replication stress;Research;response;Role;S phase;small molecule;SMARCA4 gene;spheroids;Stains;Survival Rate;SWI/SNF Family Complex;synergism;temporal measurement;Therapeutic;tool;Toxic effect;translational study;treatment duration;Treatment Efficacy;tumor;Tumor Suppressor Proteins;Validation;Work

PROJECT_TITLE: Mechanisms and small-molecule targeting of SWI/SNF activity in neuroblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]