NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: While the harms from psychoactive drug use are increasing among older adults in the United States, accurate estimates of the prevalence of psychoactive drug use, risk factors for use, chronic disease profile, and self- reported adverse outcomes associated with use among this population are lacking. This study testing a geriatric- based drug survey combined with biological drug testing in a diverse population of older adults will inform future epidemiology studies and provide critical prevention information to inform providers and policymakers across the spectrum of clinical care for older adults, including post-acute and long-term care.

PI_NAMEs: PALAMAR, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;adverse outcome;Age;age related;Aging;Area;Attention;baby boomer;Biological;Biological Testing;Cannabis;Characteristics;Chronic Disease;clinical care;Communities;comorbidity;Computers;Dangerousness;Data;design;Detection;drug testing;Drug usage;Elderly;Epidemiology;epidemiology study;experience;Exposure to;Fentanyl;fentanyl analog;Friends;Future;Generations;Goals;Hair;Harm Reduction;Health;Health system;Homelessness;Hospitalization;Hour;Housing;human old age (65+);impression;improved;Individual;Intercept;Interdisciplinary Study;Long-Term Care;marijuana use;Methods;misuse of prescription only drugs;multidisciplinary;National Institute of Drug Abuse;New York City;novel;older adult;Older Population;Patient Self-Report;Perception;Persons;Pharmaceutical Preparations;Physiological;Policy Maker;Population;Population Heterogeneity;predictive test;Predisposition;Prevalence;Prevention;Provider;Psychotropic Drugs;Public Health;Reporting;Research;Research Personnel;response;Retirement;Risk;Risk Factors;Route;Saliva;salivary assay;Sampling;Self Medication;social factors;Source;Substance Use Disorder;Surveys;Testing;Theoretical model;Time;Toxicology;transitional housing;United States

PROJECT_TITLE: Novel methods for estimating the prevalence of drug use among older adults

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Patient Safety;Pulmonary Fibrosis

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Pulmonary fibrosis (PF) is scarring of the lungs that is often progressive leading to loss of lung function and death, and interstitial lung abnormalities (ILA) are common incidental findings on chest imaging that have been shown to carry adverse consequences and as such are felt to represent early PF. This project aims to identify the best method for the risk-stratification of ILA and to improve our understanding of the clinical, proteomic, and genetic factors that are associated with disease severity in ILA. The results of this work will help to identify which patients are at high-risk for adverse outcomes that may benefit from early intervention.

PI_NAMEs: ROSE, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acceleration;Adult;Adverse event;adverse outcome;Advisory Committees;Age;Algorithms;antifibrotic treatment;Biological Assay;Biological Process;biomarker identification;career;Cessation of life;chest computed tomography;Chest imaging;Classification;Clinical;clinical diagnosis;Clinical Management;clinical risk;cohort;Complex;Critical Care;Data;Death Rate;Dedications;Detection;Development;differential expression;Disease;Disease Pathway;Early Diagnosis;Early Intervention;Enzyme-Linked Immunosorbent Assay;Exclusion;Exercise;Fibrosis;fibrotic lung;follow-up;Framingham Heart Study;functional decline;Future;General Population;Genetic;genetic epidemiology;genetic predictors;genetic variant;genome sequencing;Goals;Guidelines;high risk;high risk population;Hospitals;idiopathic pulmonary fibrosis;Image;Impairment;improved;Incidental Findings;International;interstitial;Interstitial Lung Diseases;Knowledge;Lung;Machine Learning;Measurement;Measures;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;mortality;mortality risk;MUC5B gene;multiple omics;novel;novel marker;Outcome;outcome prediction;Participant;Pathogenesis;Patients;Pattern;peripheral blood;Persons;Phase;Physicians;Physiology;Plasma Proteins;Population;preservation;Progressive Disease;protein expression;Proteins;Proteomics;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary function tests;Pulse Oximetry;Quantitative Trait Loci;Radiology Specialty;Research;Research Personnel;respiratory;Risk;risk stratification;Scanning;Scientist;Severities;Severity of illness;skills;Subgroup;supplemental oxygen;Teaching Hospitals;Techniques;Testing;Training;Training Programs;Walking;whole genome;Woman;Work

PROJECT_TITLE: Risk-stratification and prediction of adverse outcomes in interstitial lung abnormalities

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Older persons may experience reduced physical function from a combination of frailty and heart disease. A dedicated physical rehabilitation program can lead to improvement in physical function in individuals with heart failure and frailty. We will study changes in ≈700 blood proteins in response to a rehabilitation program to further understand the human biology of impaired physical function and frailty with the goal of identifying targets to modify and follow in this critical aging process.

PI_NAMEs: NAYOR, MATTHEW G. (contact);SHAH, RAVI

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adult;Age;age acceleration;age related;age related changes;Age related comorbidities;aging biomarker;aging process;aortic valve;Aortic Valve Stenosis;Biological;Biological Assay;Biological Markers;Blood Proteins;Body Composition;Body System;Cachexia;Cardiac;cardiometabolism;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;Clinical;clinical biomarkers;clinical predictors;Clinical Trials;cohort;Communities;Coronary Artery Risk Development in Young Adults Study;Data;data sharing;Dedications;Dimensions;effective intervention;EFRAC;Elderly;Exercise Test;experience;Fibrosis;follow-up;frailty;Framingham Heart Study;Functional impairment;functional status;Goals;healthy aging;Heart Diseases;Heart failure;Heterogeneity;Hospitalization;Human Biology;impaired functional status;Impairment;implantation;improved;Individual;Inflammatory;Intervention;Link;Measures;Metabolism;Methods;middle age;Molecular;molecular marker;Molecular Profiling;Morbidity - disease rate;mortality;muscle physiology;Neurocognitive;novel;Obesity;Observational Study;older adult;older patient;Older Population;Organ;Outcome;Participant;Pathway interactions;Patients;Pharmacotherapy;Phenotype;Physical Function;physical impairment;Physical Rehabilitation;Play;Policies;Population;population based;Preparation;preservation;programs;Proteins;Proteome;proteomic signature;Proteomics;Protocols documentation;Quality of life;Race;racial diversity;Randomized;randomized trial;Rehabilitation therapy;Reporting;response;Role;Sampling;Science;screening;sex;Specific qualifier value;Technology;Testing;Time;treatment as usual;treatment effect;United States National Institutes of Health;Walking;Woman;Work

PROJECT_TITLE: Effect of physical rehabilitation on molecular markers of frailty in heart failure

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: African American and Hispanic Veterans use tobacco cessation treatment at lower rates than other White Veterans, despite greater tobacco use burden. Proactive outreach attempts to address barriers in initiating tobacco cessation treatment among African American and Hispanic Veterans is important. Development and implementation of health communication interventions that address barriers at multiple health care system levels that impede use of tobacco cessation treatment have been effective in increasing use among Veterans. However, few attempts have been made to develop health communication interventions specific for African American and Hispanic Veterans. Additionally, little is known about the barriers and facilitators in delivery of tobacco cessation treatment that impact African American and Hispanic Veterans, specifically. The goal of this CDA is to collaborate with Veterans, VA personnel, and stakeholders to improve initiation of tobacco cessation treatment for African American and Hispanic Veterans, while examining factors that impact their use treatment.

PI_NAMEs: DAWSON, DARIUS B. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;African American;Area;barrier to care;Behavioral Medicine;burden of illness;Caring;Cigarette;Clinic;Clinical Trials;Coin;Collaborations;Color;Communities;Data;design;Development;Discrimination;Disease;effectiveness/implementation study;Equity;Evaluation;evidence base;Fostering;Goals;Grant;Growth;Health;Health behavior;health communication;Health Disparities Research;health equity;Health equity research;healthcare burden;Healthcare Systems;Hearing;Hispanic;hispanic community;Hispanic Populations;Hour;Human Resources;implementation strategy;improved;innovation;interest;Intervention;Interview;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Lead;member;Menthol;Methodology;Methods;military veteran;mortality;Motivation;National Institute on Minority Health and Health Disparities;novel;outreach;patient engagement;Patients;Pilot Projects;pilot trial;Population;prevent;Process;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Priority;Research Proposals;Risk;Services;skills;Smoke;social health determinants;social stigma;System;Testing;therapy development;Tobacco;tobacco cessation intervention;Tobacco use;Tobacco Use Cessation;tobacco user;Training;Training Activity;Translation Process;Translations;transmission process;treatment as usual;treatment services;Underserved Population;Update;Veterans;Veterans Health Administration;Writing

PROJECT_TITLE: Addressing Health Equity in Tobacco Cessation Treatment for Historically Underrepresented Veterans

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE The proposed research will quantify sexual orientation-related disparities in unintended pregnancies and ad- verse perinatal outcomes, intersectional disparities by race/ethnicity, and the extent to which state-level poli- cies that are restrictive around reproductive health (e.g., those related to abortion and contraception) and poli- cies that are discriminatory (e.g., reflective of heterosexism and sexism) modify these disparities. There is a high potential for public health impact because the proposed research is an essential next step towards (1) identifying particular harmful policies for policy change, (2) elucidating the mechanisms by which state policies affect unintended pregnancies and their outcomes among SMW, and (3) laying the foundation for similar re- search in other stigmatized populations.

PI_NAMEs: CHAKRABORTY, PAYAL  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Address;Affect;Award;Bisexual;career;Climate;cohort;Contraceptive methods;Coupled;court;Data;Diabetes Mellitus;Discrimination;Disparity;Environment;ethnic minority;Ethnic Origin;experience;Exposure to;Family Planning;follow-up;Foundations;Gays;geographic difference;Geography;Goals;health disparity populations;health organization;Health Policy;Healthcare;Heterosexuals;high risk;Individual;individual variation;innovation;intersectionality;Intervention;Laws;Length;Lesbian;Longitudinal cohort;Low Birth Weight Infant;marginalization;Measures;Mentors;Methodology;Modeling;multilevel analysis;National Institute of Child Health and Human Development;Nurses' Health Study;Outcome;Participant;peer;perinatal outcomes;Phase;Policies;Population;Poverty;Pregnancy;pregnancy hypertension;Pregnancy Outcome;Premature Birth;Public Health;Race;racial disparity;racial minority;reproductive;Reproductive Health;Research;Risk;same-sex partnership;Sample Size;Sex Orientation;Sexism;sexual minority;sexual minority women;sexual violence;social stigma;Spontaneous abortion;Stigmatization;stillbirth;Structure;Subgroup;Surveillance Methods;Time;Training;unintended pregnancy;United States National Institutes of Health;Variant;Violence;violence victimization;Woman;women subjects;Women's Health;Work

PROJECT_TITLE: Sexual orientation-related disparities in unintended pregnancies by state-level policy and structural contexts

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Pressure injury (PrI) prevention is a major challenge for many Veterans with spinal cord injury (SCI), often leading to prolonged bedrest, hospitalization and even death. We have shown that sustained use of gluteal intermittent stimulation (iGSTIM) provides effective automated weight shifting and reduces PrI. Users said that long-term iGSTIM usage meant they no longer worried about recurrent skin problems, with daily use fitting easily into their lives. However, a fully implanted iGSTIM system was requested. We have also been contacted by many people desperate for a new alternative to PrI prevention and asking for a simple fully implanted system. We therefore developed the innovative VA-patented flexSTIM biomimetic implantable pulse generator that in combination with industry-standard intramuscular electrodes, provides a fully implanted iGSTIM system for regular automated weight-shifting at the touch of a button. This planning grant will support preparation for a pre-IDE meeting with the FDA to establish clear preclinical testing criteria for first-in-human testing.

PI_NAMEs: BOGIE, KATH  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Agreement;Amendment;Animals;Award;Bed rest;biomaterial compatibility;Biomimetics;Bladder;Blood flow;Buttocks;Cessation of life;chemical standard;Clinical;clinical implementation;Clinical Practice Guideline;cytotoxicity;decubitus ulcer;design;Development;Devices;Documentation;Electrodes;Electronics;Elements;Engineering;Evaluation;Exhibits;Failure;Feedback;first-in-human;flexibility;Foundations;Funding;Goals;good laboratory practice;Grant;Health;Hospitalization;Hybrids;Impairment;Implant;improved;in vivo evaluation;Incidence;Individual;Industry Standard;injury prevention;innovation;Institutional Review Boards;Intestines;Intramuscular;Lead;Legal patent;Life Style;Limb structure;Maintenance;manufacture;Measures;meetings;member;Methods;Mobility decline;Modeling;Muscle;Muscular Atrophy;neuromuscular stimulation;new technology;Oryctolagus cuniculus;Outcome;Outpatients;Pattern;Persons;Phase;Physiologic pulse;pre-clinical;preclinical evaluation;Preclinical Testing;Preparation;Prevention;Procedures;programs;protocol development;Protocols documentation;Quality of life;Randomized;Recommendation;Recurrence;Research;research clinical testing;Research Design;Residual state;Safety;Schedule;Site;Skin;Spinal cord injury;Spinal Injuries;subcutaneous;Surgical incisions;synergism;System;systemic toxicity;Technology;Testing;therapeutic effectiveness;Time;Tissues;Touch sensation;Toxicity Tests;Translating;Translational Research;Translations;Travel;Veterans;Weight;Work

PROJECT_TITLE: Toward translation of flexSTIM: a biomimetic implanted pattern generator for effective long-term pressure injury prevention through automatedweight shifting and enhanced tissue health.

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Nutrition;Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: CRC Narrative The major objective of the Johns Hopkins Clinical Research Center is to provide the optimal environment for the conduct of food allergy research, including leadership at all levels as well as the staffing and other resources to conduct even the most complicated studies. The site brings to the consortium a long standing track record of recruitment and retention in CoFAR studies which we are poised to continue. In addition, this application includes an exciting network wide protocol exploring a novel treatment for peanut allergy as well as two site specific protocols led by outstanding junior investigators.

PI_NAMEs: WOOD, ROBERT A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Accidents;Administrative Personnel;Adolescence;Adult;Affect;Allergy to peanuts;American;Anaphylaxis;Charge;Child;clinical center;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communication;Databases;Development;Double-Blind Method;effective therapy;egg;Emergency Situation;Environment;experience;FDA approved;Food;Food Hypersensitivity;Goals;Health;human old age (65+);Immunologics;Immunotherapy;Impairment;improved;innovation;Intervention Trial;Investigation;investigator-initiated trial;Laboratory Personnel;Laboratory Technicians;Lead;Leadership;Left;Life;Malnutrition;Milk;National Institute of Allergy and Infectious Disease;Natural History;next generation;novel;novel strategies;Nurses;Nut Hypersensitivity;oral immunotherapy;Participant;patient population;patient subsets;Patient-Focused Outcomes;Patients;Peptide Vaccines;Performance;Pharmaceutical Preparations;Physicians;placebo controlled study;Population;Prevalence;Prevention;Protocols documentation;Qualifying;Quality of life;Reaction;recruit;Research;Research Assistant;Research Personnel;research study;Resources;Scientist;Site;skills;success;Time;Training;Translational Research;Universities;Wheat;Wood material

PROJECT_TITLE: Clinical Research Unit:  Johns Hopkins University

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (J2)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Radiation Oncology;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Response assessment remains a prevailing challenge in the clinical management of glioblastoma (GBM) because routine neuroimaging is often insufficient to differentiate true progression from treatment effects. This project aims to establish the first line of evidence on the clinical feasibility of magnetic resonance elastography (MRE) in the accurate and timely differentiation of progressive/recurrent GBM from treatment-related false positives. Success of this project will open new opportunities for a comprehensive analysis of the cellular, vascular, and biomechanical imaging markers in GBM patients to bring novel insights into the mechanisms of GBM progression and treatment response.

PI_NAMEs: DENG, BIN  (contact);GERSTNER, ELIZABETH

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Acceleration;Aftercare;Anatomy;Angiogenesis Inhibitors;Animal Model;Biomechanics;Biometry;Biophysics;Biopsy;Blood Vessels;Brain;Brain Neoplasms;Characteristics;chemoradiation;Clinical;clinical decision-making;Clinical Management;Clinical Research;clinical translation;cohort;Contralateral;Correlation Studies;Data;Deposition;Diagnosis;Diagnostic;effective intervention;effectiveness evaluation;elastography;Ensure;Environment;Evaluation;Excision;Extracellular Matrix;Fingerprint;follow-up;Frequencies;Glioblastoma;Heterogeneity;Histologic;Histopathology;Human;Image;imaging biomarker;imaging study;Imaging Techniques;improved;in vivo;innovation;insight;Intervention;Knowledge;Linear Models;Logistic Regressions;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Malignant - descriptor;Maps;Measures;Mediating;Metabolic;Methodology;Methods;Modeling;Motion;multidisciplinary;Mus;Necrosis;neoplastic cell;neovasculature;neuro-oncology;neuroimaging;neuropathology;neurosurgery;Newly Diagnosed;non-invasive imaging;novel;novel therapeutics;Odds Ratio;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Phase;Physiological;Pilot Projects;Positioning Attribute;preclinical study;prevent;Primary Brain Neoplasms;Prognosis;Property;Prospective cohort;Protocols documentation;Recurrence;research clinical testing;Resolution;response;Role;Sampling;Sampling Biases;Spatial Distribution;statistics;success;Techniques;Testing;therapy resistant;Time;tissue mapping;Tissue Sample;Tissues;treatment effect;treatment optimization;treatment planning;treatment response;treatment strategy;tumor;Tumor Burden;tumor heterogeneity;tumor microenvironment;tumor progression;viscoelasticity;white matter;Xenograft procedure

PROJECT_TITLE: Response assessment of glioblastoma using magnetic resonance elastography

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (J2)]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Food allergy is a growing problem in the United States that continues to affect millions of patients across a broad range of demographics. CoFAR will establish a national network of Clinical Research Centers to participate in multi-center clinical trials to identify and validate novel therapeutic and preventive strategies for food allergy that are safe, effective, and accessible. A CRC based in the University of North Carolina will bring experienced food allergy investigators, unique food allergy-specific infrastructure and facilities, and access to a large and diverse study population in support of the CoFAR network.

PI_NAMEs: KEET, CORINNE ;KIM, EDWIN  (contact)

PROJECT_TERMS: 4 year old;Adult;Affect;Allergic;Allergic Disease;Allergic Reaction;alpha-gal syndrome;American;Anaphylaxis;Antigens;Attitude;Basophils;Biological Markers;Caring;Cashew nut;Child;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Complex;cost;Coupled;cytokine;demographics;desensitization;design;Development;Diagnosis;Disease remission;Education;efficacy evaluation;Enrollment;Enterocolitis;Eosinophilic Esophagitis;experience;Faculty;flexibility;Flow Cytometry;Food;Food Hypersensitivity;Future;Grant;health care service utilization;Health Status;Hypersensitivity;IgE;Immune Tolerance;Immunoglobulins;Individual;Infrastructure;innovation;interest;International;Laboratories;Lead;Leadership;Mediating;Mentorship;metabolomics;Multi-Institutional Clinical Trial;Multicenter Studies;Multicenter Trials;next generation;North Carolina;novel therapeutics;operation;oral immunotherapy;outcome prediction;patient population;patient registry;Patients;Phenotype;placebo controlled study;Positioning Attribute;predicting response;preference;Prevention strategy;Productivity;prospective;Proteins;Public Health;Qualifying;Quality of life;randomized placebo controlled trial;Reaction;Readiness;Recording of previous events;Registries;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Risk;Safety;Site;skills;Students;study population;sublingual immunotherapy;success;Training;training opportunity;United States;Universities;Work;Writing

PROJECT_TITLE: UNC Food Allergy Initiative


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Growing evidence links traffic-related air pollution (TRAP), a complex mixture of gasses and particles, to neurotoxicity and Alzheimer’s disease and related dementias (ADRD). This study will: 1) investigate potential mechanisms by which TRAP mixtures, including ultrafine particles (UFP) with high toxic potential, may impact ADRD through neuropathologic changes; 2) combine existing and newly collect measures of UFPs to develop the first long-term UFP exposure models; and 3) investigate different timing of exposures that may be associated with ADRD neuropathologies as well as address survival biases in autopsy samples. The principal investigator will leverage extensive, state-of-the-art neuropathology measures from one of the largest community-based autopsy cohorts in the word; rich exposure models for UFP/TRAP; existing expertise in exposure assessment; and new training in ADRD neuropathologies, exposure mixtures, and advanced epidemiology to gain new insights and support targeted ADRD interventions.

PI_NAMEs: BLANCO, MAGALI NOHEMY (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: abeta deposition;Address;Adsorption;Adult;Age;aging population;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Apolipoprotein E;Area;Arterioloscleroses;Atherosclerosis;Attention;Attenuated;Autopsy;Biological Factors;Brain;Carbon Black;career;cerebrovascular pathology;Cerebrum;Child;Clinical;Clinical Data;Cognitive;cohort;Communities;Complex Mixtures;Data;demographics;design;Development;Diameter;Diet;Drops;Economics;Environmental Exposure;Epidemiologic Methods;Epidemiology;Evidence based intervention;Exercise;experience;Exposure to;fine particles;Funding;Future;Gases;Goals;Health;hyperphosphorylated tau;improved;Individual;Infarction;Inflammation;innovation;insight;interest;International;Intervention;Investigation;late life;Lead;Learning;lifestyle factors;Link;low socioeconomic status;Measurement;Measures;Medical;Mentorship;Methods;Modeling;modifiable risk;Monitor;mortality risk;Neurofibrillary Tangles;neuropathology;neurotoxic;neurotoxicity;Nitrogen Oxides;novel;older adult;olfactory bulb;Outcome;Oxidative Stress;Participant;particle;particle counter;particle exposure;Pathology;Poison;pollutant;Pollution;Population;Positioning Attribute;Predisposition;Principal Investigator;Qualifying;Recording of previous events;Registries;Regulation;Reporting;Research;Risk Factors;Sampling;Science;skills;social;Surface;Techniques;Time;Toxic effect;Toxicology;traffic-related air pollution;Training;ultrafine particle;Woman;young adult

PROJECT_TITLE: Alzheimer's Disease and Related Dementia Neuropathologies and Exposures to Traffic Pollution Mixtures

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Genetic variants between humans and other mammals underlie the unique cognitive features that have evolved in the human lineage. Unfortunately, these variants and their resulting human neural specializations are also commonly dysregulated in diseases such as autism spectrum disorder. To identify and characterize genetic variants that underlie human cognition and may be mutated in neurological diseases, this study will use the human-chimpanzee tetraploid system and comparative genomics to prioritize variants for functional study, and evaluate variants in CRISPR inhibition screens in a high-throughput manner.

PI_NAMEs: SONG, JANET  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Affect;autism spectrum disorder;Boston;Brain;causal variant;Cell fusion;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cohort;comparative genomics;consanguineous family;Data;Disease;disease phenotype;disorder risk;DNA;Elements;Enhancers;Evolution;excitatory neuron;Foundations;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Risk;genetic variant;Genome;genome-wide analysis;Genomic approach;Genomic Segment;Genomics;Human;improved;Individual;induced pluripotent stem cell;innovation;insight;Link;Mammals;medical schools;Mentors;Mutate;nerve stem cell;Nervous System Disorder;neural;Neurobiology;Neurodevelopmental Disorder;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;Nucleic Acid Regulatory Sequences;Pan Genus;Pediatric Hospitals;Phase;Phenotype;Positioning Attribute;Primates;programs;Publishing;Research;Schizophrenia;Secure;skills;System;Testing;Untranslated RNA;Variant;Work

PROJECT_TITLE: Genomic approaches to understand human neural specializations

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (02)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This application focuses on mentoring the next generation of interprofessional clinician investigators and preparing them to apply social determinants of health (SDOH) and prevention and health promotion lenses on patient-oriented research. The proposed research activities will provide opportunities to train clinician investigators in SDOH, health equity, community health, and intervention research that positively impacts practice and policy.

PI_NAMEs: JIMENEZ, MANUEL E (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Academy;Address;American;Area;behavioral health;Books;Caregivers;Child;Child Development;Childhood;Clinic;Clinical;Cognitive;Communication;Communities;community engaged research;Community Health;Complex;Consensus;design;Development;Developmental Delay Disorders;Disadvantaged;Discipline of Nursing;Dose;early childhood;Education;Effectiveness;Emotional;Environment;evidence base;experience;Family;feasibility testing;Funding;Health;Health behavior;health equity;health inequalities;Health Promotion;Healthcare;Home;implementation science;implementation strategy;Inequity;informant;insight;Intervention;Intervention Studies;Interview;Knowledge;Language;Lead;lens;Life Cycle Stages;literacy;Lived experience;Medicine;member;Mentors;Mentorship;Methods;Modeling;Neighborhood Health Center;Neuronal Plasticity;next generation;Nurse Practitioners;Nurses;Outcome;Parents;patient oriented;patient oriented research;Pediatric Nursing;Pediatrics;Personal Satisfaction;physical conditioning;Physicians;Policies;Prevention;Preventive;Primary Care;primary care clinician;primary care patient;primary care setting;primary care visit;Procedures;programs;Proxy;Readiness;Reading;Reporting;Research;Research Activity;Research Personnel;Resources;response;Risk;Sampling;Schools;Science;Scientist;social;social health determinants;standard of care;Testing;Time;Training;Trust;Variant;Work

PROJECT_TITLE: Mentored patient-oriented research that applies a social determinants of health lens to promote optimal developmental and behavioral health in primary care

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Lung;Pulmonary Hypertension;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PHR: PROJECT NARRATIVE Pulmonary vascular diseases, such as pulmonary hypertension, are devastating disorders that are associated with high morbidity and mortality with frustratingly limited treatment options. Endothelial cell dysfunction is a key contributor to disease pathogenesis and stem cell-based therapies to replace diseased endothelial cells holds immense promise for new therapeutic approaches to treat pulmonary vascular disease. This proposal leverages a novel approach for induced pluripotent stem cell-derived endothelial replacement therapy to dissect the mechanisms that promote cellular engraftment and to test the efficacy of this approach in genetic pulmonary vascular disease models.

PI_NAMEs: HOLTZ, ALEXANDER MATTHEW (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Activities of Daily Living;ACVRL1 gene;Affect;Alveolar capillary dysplasia with misalignment of pulmonary veins;Autologous;Award;Biological Assay;Blood Vessels;BMPR2 gene;Boston;career;career development;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell replacement therapy;Cell Therapy;Cell Transplantation;Cells;Cellular biology;Collaborations;CRISPR/Cas technology;Data;Defect;Development;directed differentiation;Disease;disease model;efficacy testing;Embryo;Endothelial Cells;Endothelium;Engraftment;fitness;fluorophore;FOXF1 gene;Frustration;Functional disorder;gene correction;Gene Expression Profile;Gene Mutation;Genetic;Genomics;Goals;Grant;Hematopoietic stem cells;Heterogeneity;Human;human induced pluripotent stem cells;Hyperoxia;Immunocompetent;Immunocompromised Host;Immunohistochemistry;Immunosuppression;in vivo monitoring;Individual;induced pluripotent stem cell;Injury;Institution;Integral Membrane Protein;Label;Longevity;Luciferases;Lung;lung injury;Manuscripts;Measures;Mediating;Medical center;meetings;Mentors;molecular phenotype;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;notch protein;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ;Pathogenesis;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;Patients;Pattern;Pediatric Hospitals;Physicians;Population;Positioning Attribute;Pre-Clinical Model;Preparation;Process;progenitor;Pulmonary Hypertension;pulmonary vascular disorder;receptor;reconstitution;Regenerative Medicine;Replacement Therapy;Reporter;Research;Role;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell biology;stem cell function;stem cell therapy;Syndrome;System;Testing;Time;Tissues;Training;translational potential;transplant model;Transplantation;Universities;Variant;vasculogenesis;Work

PROJECT_TITLE: Endothelial cell-based therapy for pulmonary vascular disease using induced pluripotent stem cells


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Veterans with mid to later stage Parkinson’s disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. We will compare how effective working out a lot one week per month with a break of three weeks is to continuously exercising weekly with no breaks in people with mid stage PD. We will look at how fast they walk per minute, whether they become more physically active, the biochemicals in their blood, and at how stiff their blood vessels are before and after the exercise.

PI_NAMEs: HACKNEY, MADELEINE EVE (contact)

PROJECT_TERMS: Accelerometer;Aerobic;Aerobic Exercise;Affect;behavior measurement;Biochemical;Biological Markers;Blood;Blood Vessels;brain cell;Brain-Derived Neurotrophic Factor;Cardiovascular system;Clinical Trials;clinically relevant;Cognition;cohort;cytokine;Dancing;Data;Development;Disease Progression;Dose;Evaluation;executive function;Exercise;exercise intensity;Exercise Therapy;Expenditure;Frequencies;Future;Gait;gait rehabilitation;Hour;IL7 gene;improved;Inflammatory;Infrastructure;interest;Intervention;Light;Measures;Mission;Motor;motor disorder;Nerve Degeneration;Neurodegenerative Disorders;neuromuscular;Outcome;Outcome Measure;Outcomes Research;Parkinson Disease;Participant;Patients;Persons;Physical activity;Predisposition;prevent;primary outcome;Process;programs;Publishing;Quality of life;Questionnaires;recruit;Research;Research Infrastructure;Resources;Rest;Schedule;sensor;Serology;Severity of illness;Testing;Time;Veterans;VO2max;Walking;Work

PROJECT_TITLE: Moderate versus High Volume Light-Moderate Intensity Exercise for People with Moderate Parkinson's Disease

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: GREENVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE The effects of rising environmental temperatures are being felt around the globe and are recognized as an emerging public health threat, disproportionately causing death of farmworkers. To best prepare farm workers and other workers to safely adapt to increased outdoor temperatures, there is a critical need to implement an effective heat-related illness (HRI) preventive hydration intervention. Utilizing community-based participatory research and implementation science, this work seeks to set the stage for developing occupational interventions that reduce morbidity and mortality related to HRIs.

PI_NAMEs: MIZELLE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Backpack Hydration System Use Among Farmworkers

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: High resolution imaging is a corner stone of pre-clinical research. We request funds to purchase a high resolution microcomputed tomograph with high scan speeds and high resolution to support a total of 19 major and minor NIH supported users for their bone and vascular disease research.

PI_NAMEs: PINZ, ILKA M (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Algorithmic Analysis;animal imaging;Area;automated image analysis;base;bone imaging;calcification;Centers of Research Excellence;Client;Clinical Research;Computer software;Contract Services;Core Facility;cost;Development;Dose;Faculty;Funding;Grant;high resolution imaging;Human Resources;Image;Image Analysis;imager;imaging facilities;imaging software;in vivo;in vivo imaging;Institution;Length;Life;Magnetic Resonance;Magnetic Resonance Imaging;Maine;Medical center;member;Minor;Mus;New England;pre-clinical;programs;Rattus;Request for Proposals;Research Institute;Research Personnel;Resolution;Resources;Scanning;Services;Slide;soft tissue;Specimen;Speed;System;tomography;translational research program;ultrasound;United States National Institutes of Health;Universities;user-friendly;Vermont;Writing

PROJECT_TITLE: SKYSCAN 1276 CMOS in vivo microCT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


PHR: Narrative: Leadership Center Research Strategy The major objective of the Leadership Center is to oversee the scientific direction for CoFAR, as well as the financial, operational, and managerial aspects such that the next phase of the consortium, including both interventional trials and clinical studies, can be conducted in the most rigorous, safe, efficient, and fiscally sound manner possible. This will be accomplished through a seamless working relationship with the NIAID and the Statistical and Clinical Coordinating Center (SACCC), as well as each of the Clinical Research Centers (CRCs). The outstanding record of accomplishment and leadership of the Principal Investigators on this application will ensure that CoFAR remains a global leader in the food allergy research.

PI_NAMEs: BUNYAVANICH, SUPINDA ;SICHERER, SCOTT H;WOOD, ROBERT A (contact)

PROJECT_TERMS: Accidents;Administrator;Adolescence;Adult;Affect;Allergy to peanuts;Alzheimer disease prevention;American;Biological Markers;Biological Response Modifier Therapy;Child;Climacteric;Clinical;clinical practice;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Data Analyses;Data Collection;Development;Disease;Dose;Educational process of instructing;effective therapy;egg;Emergency Situation;Ensure;Evaluation;experience;FDA approved;Food;Food Hypersensitivity;food protection;Funding;Future;Goals;Grant;Guidelines;Height;human old age (65+);IgE;Immunologics;Immunotherapy;Impairment;Individual;Infant;International;Intervention Trial;Investigation;Laboratory Study;Lead;Leadership;Left;Life;Malnutrition;Milk;National Institute of Allergy and Infectious Disease;Natural History;next generation;novel;novel strategies;Nut Hypersensitivity;Occupational activity of managing finances;omalizumab;operation;Oral;patient subsets;Patients;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;Pregnant Women;Prevalence;prevent;Prevention;Prevention Protocols;Prevention strategy;Principal Investigator;Procedures;Productivity;protocol development;Protocols documentation;Publications;Quality of life;Reaction;Research;Resources;Science;Severities;sound;Structure;Time;Translations;treatment response;Vision;Wheat;Wood material;Work

PROJECT_TITLE: New Horizons in the Prevention and Treatment of Food Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LP-I (J2)]


ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

ORG_STATE: NY

PHR: This proposal is important for public health as it seeks to acquire a state-of-the-art slide scanner that will significantly enhance research on chronic neurological disabilities. By advancing our understanding of these conditions and developing new therapeutic interventions, this proposal aims to improve the health and well- being of individuals affected by neurological disorders.

PI_NAMEs: HOLLIS, EDMUND R (contact)

PROJECT_TERMS: Aging;Algorithms;Area;Chronic;Core Facility;Dedications;Functional Imaging;Funding;Image;imaging system;Investments;light microscopy;Microscopy;Modernization;multiphoton microscopy;Neurologic;Neurological disability;programs;Research;Research Personnel;Research Project Grants;Resolution;Resources;Scanning;Slide;structural imaging;System;Time;Tissues;United States National Institutes of Health

PROJECT_TITLE: An advanced, high-throughput imaging system for the BNI Structural and Functional Imaging Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative This renewal application proposes to validate early detection biomarker signatures comprising of pathway associated circulating transcriptomics, proteomics and metabolomics (omics) biomarkers and integrate them with machine learning method derived high resolution imaging features associated with heterogenous pancreatic ductal adenocarcinoma (PDAC) disease subtypes. Integration of Omics data with CT/MRI imaging features will be done by developing Multimodal Integrative Analytical Models (MIAM) predictive of early stage pancreatic cancer. Validation of the integrated biomarker signatures and their association with PDAC subtypes will be investigated in Phases II, III and IV studies according to PRoBE-design while performance in phase IV study for detecting early stage disease and predicting clinical outcomes among asymptomatic patients and at-risk individuals will be ascertained with retrospective and prospective longitudinal pre-diagnostic sample cohorts, including one representing an underserved population.

PI_NAMEs: KILLARY, ANN M;KOAY, EUGENE J;SEN, SUBRATA  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Algorithms;assay development;biobank;Biological Markers;Biology;biomarker identification;biomarker panel;biomarker performance;biomarker signature;biomarker validation;candidate marker;cell type;Characteristics;circulating biomarkers;clinical diagnostics;clinical risk;clinically significant;cohort;Computer software;Data;Data Analyses;data integration;data sharing;design;Detection;Development;Diagnosis;Diagnostic;Disease;disease model;Disease Progression;disorder subtype;early detection biomarkers;Early Diagnosis;Funding;Future;Genetic;Goals;Grant;Heterogeneity;high resolution imaging;high risk;Image;imaging approach;Individual;innovation;Laboratories;Lead;Lesion;machine learning method;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of pancreas;MCAM gene;member;metabolomics;Modality;Modeling;Molecular;molecular subtypes;MRI Scans;multimodality;novel;open source;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Performance;Phase;phase 4 study;predict clinical outcome;predictive modeling;Predisposition;prospective;Prospective cohort;Proteomics;Resectable;Risk;Risk Assessment;risk stratification;Sampling;screening;Time;transcriptomics;Translating;Underserved Population;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (J2)]


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE This proposal will generate myotropic rAAV2/HBoV1 vectors of improved tropisms to skeletal and cardiac muscles for delivery of gene of up to 5.9-kb. The large size rAAV2 genome will facilitate muscle-specific expression and gene editing elements for treatment of genetic muscular diseases, such as Duchenne muscular dystrophy.

PI_NAMEs: QIU, JIANMING  (contact);YAN, ZIYING

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: adeno-associated viral vector;Adopted;airway epithelium;Animal Model;Apical;base editor;Capsid;Capsid Proteins;Cell Nucleus;Chimeric Proteins;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;CRISPR/Cas technology;Cystic Fibrosis;Deaminase;Defect;Development;Directed Molecular Evolution;Dose;Duchenne muscular dystrophy;Dystrophin;Elements;Engineering;Enterobacteria phage P1 Cre recombinase;Evolution;Exons;gene correction;Gene Delivery;gene replacement;gene therapy;Gene Transduction Agent;gene-editing approach;Genes;Genetic;Genome;genome editing;Goals;Human;Human Genome;Hybrids;improved;In Vitro;in vivo;Libraries;Location;Mediating;micro-dystrophin;Mus;Muscle;Muscle Cells;Muscle Fibers;mutant;Mutate;Mutation;mutation correction;Myoblasts;Myocardium;Myopathy;next generation;next generation sequencing;Nonhomologous DNA End Joining;Nonsense Mutation;novel;Open Reading Frames;Organ;Outcome;Parvovirus;Patients;Peptides;Phage Display;premature;Production;Productivity;Protein Truncation;Proteins;prototype;Recombinant adeno-associated virus (rAAV);Regulation;Regulatory Element;respiratory;respiratory virus;RGD (sequence);screening;Skeletal Muscle;Specificity;Striated Muscles;structural biology;Structure;success;Surface;Terminator Codon;Therapeutic Effect;therapeutic genome editing;Tissues;transduction efficiency;Transgenic Mice;Treatment Efficacy;Tropism;Variant;vector;Virus;Writing;X Chromosome

PROJECT_TITLE: Development of myotropic human bocavirus vectors for gene therapy

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Complementary and Integrative Health;Dissemination and Implementation Research

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

PHR: Narrative Up to 70% of cancer patients utilize complementary and alternative therapies (CAM) in cancer care, which was associated with lower adherence to standard care. Unfortunately, many patients make CAM decisions without involving their healthcare providers, missing the opportunity for CAM-related information validation. Dr. Fridman develops an intervention to overcome patient and provider barriers to transparent welcoming patient-provider conversations about CAM and CAM misinformation.

PI_NAMEs: FRIDMAN, ILONA  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Adherence;adherence rate;Alternative Therapies;Attitude;Behavior;Breast;cancer care;Cancer Center;Cancer Control;Cancer Patient;cancer therapy;clinical practice;Clinical Trials;Collaborations;Communication Barriers;Complementary therapies;Consolidated Framework for Implementation Research;Control Groups;Decision Making;design;Development;Educational workshop;Effectiveness;empowerment;Evidence based treatment;Exercise;Exhibits;experience;experimental group;Exposure to;feasibility testing;Feedback;Focus Groups;Foundations;Frequencies;Goals;Health;health communication;Health Personnel;Health Professional;human centered design;improved;ineffective therapies;interest;Intervention;Interview;Knowledge;Lead;Learning;Life Expectancy;Low Prevalence;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medicine;Methodology;Misinformation;Oncologist;Outcome;patient engagement;patient response;patient-level barriers;Patients;Perception;Physicians;Planning Theory;Play;Prevalence;professor;Prostate;prototype;Provider;provider-level barriers;Qualitative Methods;Qualitative Research;Research;Risk;Role;Safety;Sampling;Self Efficacy;social media;social norm;standard care;Suggestion;Testing;Time;tool;Training;Trust;tumor progression;Urologic Oncology;Validation;webinar

PROJECT_TITLE: Cancer Misinformation and Use of Complementary and Alternative Therapy (CAM) among Patients with Cancer.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative The proposed research is designed to p110β and ATR in PTEN-deficient CRPC mouse models and to investigate the underlying molecular mechanisms of combined effect of ATR inhibitor and p110β evaluate the anti-tumor activity and immunity of combined inhibition of inhibitor in DNA damage-induced cells death in PTEN-deficient CRPC cells . Our research will potentially provide fundamental evidence of DNA damage-induced cell death and anti-tumor immunity in PTEN-deficient CRPC after inhibition of p110β and ATR, and a novel mechanism-based combination therapy to treat CRPC patients harboring genetic alterations of PTEN.

PI_NAMEs: DING, LIYA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Aftercare;Allografting;androgen deprivation therapy;androgen independent prostate cancer;anti-tumor immune response;Antigen Presentation;Apoptosis;ATR gene;cancer cell;Cancer Patient;cancer therapy;Cell Cycle;Cell Death Induction;Cell Survival;Cells;CHEK1 gene;chemokine;Clinic;Clinical Data;Coculture Techniques;Combined Modality Therapy;cytokine;Data;Defect;Dendritic cell activation;Dendritic Cells;design;Diagnosis;Disease;Disseminated Malignant Neoplasm;DNA biosynthesis;DNA Damage;DNA Repair;effective therapy;enzalutamide;Exhibits;experimental study;Gamma-H2AX;Genes;Genetic;Genetically Engineered Mouse;genome integrity;Genomic Instability;Histocompatibility Antigens Class I;Human;Human Cell Line;Immune system;Immunity;Immunotherapy;In Vitro;in vivo evaluation;indexing;inhibitor;male;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mitotic;Molecular;mortality;mouse model;Mus;Mutate;Mutation;neoplastic cell;novel;novel therapeutics;Oncogenic;Pathway interactions;Patients;PC3 cell line;pembrolizumab;pharmacologic;Phosphorylation;Phosphotransferases;PIK3CG gene;Poly(ADP-ribose) Polymerase Inhibitor;preclinical evaluation;prostate cancer cell;prostate cancer progression;Protein Isoforms;PTEN gene;Relapse;replication stress;Reporting;Research;response;Role;Signal Pathway;Signal Transduction;synergism;System;Testing;Therapeutic Effect;therapy resistant;Toxic effect;TP53 gene;Translational Research;Treatment Efficacy;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;Tumor-infiltrating immune cells;VCaP

PROJECT_TITLE: Combined inhibition of ATR and p110β as Therapy in PTEN-deficient Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J2)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Neurosciences;Psoriasis;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Psoriatic arthritis is a progressive, erosive, and destructive disease that often leads to disability and is strongly associated with poor sleep health. This project seeks to understand the contribution of poor sleep health to inflammation and disease activity in patients with psoriatic arthritis. Given that multiple components of sleep health are modifiable risk factor(s), the information provided through this study could support the development and testing of interventions to improve sleep health and disease activity in psoriatic arthritis.

PI_NAMEs: PEREZ CHADA, LOURDES  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Achievement;actigraphy;Adult;alertness;Anti-Inflammatory Agents;Arthralgia;arthritis registry;Biological Assay;Biostatistical Methods;Blood specimen;career;career development;catalyst;Chronic;chronic inflammatory disease;circadian;Clinical;cohort;Collection;Complementary therapies;Data;Dermatologist;Development;Development Plans;diaries;Dimensions;disability;Disease;Disease Marker;Enrollment;Environment;Epidemiologic Methods;experience;Faculty;falls;Funding;Goals;health related quality of life;Hospitals;Hydrocortisone;improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;Interleukin-10;Interleukin-6;Intervention;joint inflammation;Knowledge;Lead;Learning;longitudinal, prospective study;Measures;Mediating;Mediator;medical schools;Medicine;member;Mentors;modifiable risk;Musculoskeletal;Musculoskeletal Diseases;Neurobiology;novel;novel therapeutics;Outcome;Outcome Measure;Pain;Pathway interactions;patient oriented;Patient Outcomes Assessments;Patients;Physicians;Pittsburgh Sleep Quality Index;poor sleep;Positioning Attribute;Probability;Prospective Studies;Pruritus;Psoriasis;Psoriatic Arthritis;Public Health Schools;Qualifying;Qualitative Research;Quality of life;Questionnaires;Recommendation;Recording of previous events;Registries;Reporting;Research;research and development;Research Personnel;Research Training;Resolution;Resources;respiratory;Rheumatology;Risk Factors;Scientist;Serum;Severities;skills;Skin;skin disorder;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep physiology;sleep quality;Symptoms;systemic inflammatory response;Testing;Time;TNF gene;Training;Training Programs;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Longitudinal relationships among sleep health, systemic inflammation, and disease activity in psoriatic arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: The connecting cilium and adjacent regions of the photoreceptor cell perform a spectrum of functions vitally important for our vision, ranging from protein sorting and trafficking to biogenesis of the light-capturing membranes. However, the limited knowledge of the molecular composition of this critical part of the cell impedes our ability to elucidate the underlying mechanisms. We propose to close this knowledge gap by identifying and quantifying unique protein components of this photoreceptor region, thereby facilitating the progress in our understanding photoreceptor biology and disease.

PI_NAMEs: SKIBA, NIKOLAI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Area;base;Biochemical;Biogenesis;Biology;Cell membrane;Cells;Cellular Structures;Cilia;Complex;cost efficient;Custom;Data;Defect;Degenerative Disorder;design;Detection;Disease;Distal;Exclusion;extracellular;Eye;Eye diseases;Freezing;Funding Mechanisms;genetic approach;Goals;Histologic;Hot Spot;Human;Immunohistochemistry;Individual;information processing;interest;Investigation;Knowledge;Label;Laboratories;Language;Length;Light;Location;Maintenance;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;Methodology;Modernization;Molecular;Morphogenesis;neuronal cell body;Neurons;novel;Pathology;Peptides;Photons;photoreceptor disc;Photoreceptors;Process;Protein Biosynthesis;Protein Databases;protein distribution;Protein Sortings;protein transport;Proteins;Proteome;Proteomics;Rattus;Recombinant Proteins;Reporting;Research;Resources;Retina;Retinal Photoreceptors;Role;Route;Side;Signal Transduction;Site;Sorting;Structure;Subcellular structure;Techniques;Therapeutic;Thick;Thinness;Time;Tissues;trafficking;Vision;Visual Signal Transduction Pathway

PROJECT_TITLE: Quantitative proteome of the photoreceptor outer-inner segment junction

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: NARRATIVE MARC at Florida International University provides motivated undergraduate juniors and seniors from underrepresented groups with tools, skills, and a sense of belonging that will allow each to successfully enter, excel in, and complete a biomedical or behavioral sciences Ph.D. or M.D./Ph.D. program. This will be accomplished by immersing each MARC trainee in a supportive and stimulating research lab of an active researcher with a successful undergraduate mentoring record, who will develop the individual student’s skills and properly nurture and enhance the trainee’s interest in science. The MARC program will supplement the trainees’ FIU scientific research experience with personal advising, weekly program meetings, professional and academic development workshops, technical skills workshops, holistic wellness workshops, opportunities for scientific presentations, networking opportunities, leadership opportunities, community outreach events, and facilitate participation in a summer research program at an extramural research-intensive university.

PI_NAMEs: MILLS, DEETTA K (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Behavioral Sciences;Biology;Biomedical Engineering;Biomedical Research;biomedical scientist;Black race;career;CCL7 gene;Chemistry;Classification;Communities;Community Outreach;design;Development;Doctor of Medicine;Doctor of Philosophy;doctoral student;Educational process of instructing;Elements;Employment;Enrollment;Environment;Event;experience;Extramural Activities;falls;Florida;Health;Hispanic;Hispanic-serving Institution;Individual;Institution;interest;International;Leadership;meetings;Mentors;Minority Groups;Mission;peer coaching;programs;Psychology;Research;Research Activity;Research Personnel;Research Project Grants;Rewards;Science;Scientist;skill acquisition;skills;social capital;STEM research;Structure;Students;summer research;Technical Expertise;tool;Training Programs;Travel;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Vision;waiver

PROJECT_TITLE: MARC U*STAR at Florida International University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Following the recent Supreme Court ruling in Dobbs v. Jackson Women’s Health, several states have banned or severely restricted abortion care. Just as these policies are expected to exacerbate inequities in perinatal health and reproductive autonomy, policies that expand Medicaid coverage for abortion may mitigate inequities. The proposed training will facilitate my proficiency with modernized Medicaid data, statistical and machine learning methods for causal inference, perinatal health services research, and research translation, providing me with the requisite tools to evaluate the effects of abortion bans and Medicaid abortion coverage expansions on contraceptive method use, births, and adverse perinatal outcomes in Medicaid populations on average at a population-level, and among marginalized subgroups based on race, ethnicity, age, and disability.

PI_NAMEs: ELLISON, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: abortion;access disparities;Adolescent;Adult;Adverse event;Affect;Age;Algorithms;Area;barrier to care;Birth;Black Populations;Black race;career;career development;Caring;Characteristics;child bearing;Constitution;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Country;court;Criminal Abortion;Data;Development;disability;disabled;Enrollment;Equity;Ethnic Origin;evidence base;Exercise;experience;forest;Fright;Funding;geographic difference;Goals;graduate school;health inequalities;health management;Health Policy;Health Services;Health Services Research;Hispanic Populations;improved;Indigenous;Inequity;K-Series Research Career Programs;Knowledge;Latinx;Legal;long-standing disparities;Low income;machine learning method;marginalization;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Medical;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modernization;Morbidity - disease rate;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Outcome;outcome disparities;overpopulation;patient population;Patients;payment;perinatal health;perinatal outcomes;person centered;Persons;Phase;Policies;Policy Research;Population;Postpartum Period;Pregnancy;Pregnancy Complications;Premature Birth;professor;programs;Public Health;Public Health Schools;Race;Reporting;reproductive;Reproductive Health;Research;Research Personnel;routine care;Scholarship;Scientist;service delivery;Services;social;Specific qualifier value;Spontaneous abortion;statistical and machine learning;Statistical Methods;Sterilization;Stratification;Subgroup;Testing;tool;Training;Translational Research;treatment effect;United States National Institutes of Health;Universities;Unwanted pregnancy;Variant;women with disabilities;Women's Health;Work;young adult

PROJECT_TITLE: Evaluating Reproductive Health Policy in Medicaid Populations: Application of Novel Methods for Heterogenous Treatment Effect Estimation

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive disease of lung arteries that causes shortness of breath, heart failure, and death. In PAH, lung artery cells show abnormal dependence on proline, a building block of proteins, for their growth and function. Understanding how and why lung cells become dependent on proline may identify strategies to prevent lung artery destruction, shortness of breath, heart failure, and death from PAH.

PI_NAMEs: WERTHEIM, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: amino acid metabolism;Arteries;Binding;Biological Assay;Biological Availability;Biomass;career development;Catabolism;Cell membrane;Cell Proliferation;Cells;Cessation of life;Chimera organism;Clinical;Collagen;Collagen Fibril;Complement;Coupling;Data;Dependence;Deposition;Development;endothelial dysfunction;Endothelium;Exposure to;Extracellular Matrix;Fibrosis;Functional disorder;Future;Genes;glucose metabolism;glucose uptake;Goals;Growth;Heart failure;High Pressure Liquid Chromatography;Histologic;Histology;Human;human interactome;Hydroxyproline;Hypoxia;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Impairment;in silico;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;Isotopes;knock-down;Label;Link;Lung;mass spectrometric imaging;Measures;Medicine;Membrane;Metabolic;metabolic phenotype;Metabolism;Modeling;Molecular;Monocrotaline;mortality;novel;Oncoproteins;Ontology;overexpression;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Phosphorylation;Phosphotransferases;pre-clinical;prevent;Progressive Disease;Proline;proline permease;protein-tyrosine kinase c-src;Proteins;pulmonary arterial hypertension;Pulmonary arterial remodeling;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;Rattus;recruit;Regulation;Resources;Right Ventricular Dysfunction;right ventricular failure;Sampling;Shortness of Breath;Signal Transduction;src-Family Kinases;stable isotope;Supporting Cell;Systems Biology;Systolic Pressure;Testing;Tracer;transcription factor;transcriptomics;tumor metabolism;Tyrosine;uptake;Vascular Diseases;Vasodilator Agents;Western Blotting

PROJECT_TITLE: Endothelial Proline Utilization in Pulmonary Arterial Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The current proposal seeks to develop single-fluorophore-based, high-performance, ultrasensitive biosensors for kinases and epigenetics. These biosensors will be used as functional multiparameter readouts to investigate kinase-epigenome coordination to develop focused ultrasound controllable CAR-T Therapy. The success of this project will revolutionize biosensor engineering and have a transformative impact on developing novel controllable CAR-T cells for the treatment of cancer and other diseases.

PI_NAMEs: LIU, LONGWEI  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Achievement;Address;Affect;Area;Behavior;Benchmarking;Bioinformatics;Biosensor;cancer cell;cancer immunotherapy;cancer therapy;CAR T cell therapy;Cell Line;Cell model;Cell Physiology;Cells;chimeric antigen receptor T cells;Chromatin;Color;design;detection sensitivity;Development;Directed Molecular Evolution;Disease;Engineering;Environment;epigenetic marker;Epigenetic Process;epigenome;Evolution;exhaust;exhaustion;Fluorescence Resonance Energy Transfer;fluorophore;Focused Ultrasound;functional restoration;Genes;high throughput screening;Histones;Image;imaging modality;imaging platform;Immune;immunoengineering;improved;In Situ;In Vitro;inhibitor;innovative technologies;insight;Kinetics;knock-down;knockout gene;Link;live cell imaging;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Neoplasms;Mammalian Cell;Measures;Mentors;Methods;Modification;Molecular;Monitor;multiplexed imaging;Mutagenesis;next generation sequencing;novel;Pattern;Performance;Phenotype;Phosphotransferases;Play;prevent;Protein Dynamics;Protein Kinase;Protein Tyrosine Kinase;Protein-Serine-Threonine Kinases;prototype;Rejuvenation;Research;response;Rest;sensor;side effect;Signal Transduction;Solid Neoplasm;spatiotemporal;Specificity;success;System;T cell regulation;T-Cell Activation;T-Lymphocyte;technology platform;Therapeutic;tool;tumor;Visualization;Work;ZAP-70 Gene

PROJECT_TITLE: Development of single fluorophore biosensors for multiplex imaging of CAR T Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative The clinical experience with anti-PD-1 immune checkpoint inhibition in ovarian cancer has been disappointing. We have shown that a novel Th17-inducing dendritic cell vaccine markedly enhances responses to anti-PD- 1 treatment in a mouse model of ovarian cancer, thus paving the way for a phase II clinical trial for Th17-DC vaccination plus pembrolizumab in patients with advanced stage ovarian cancer. This proposal will test the paradigm-shifting hypothesis that the efficacy of anti-PD-1/Th17-DC vaccination is dependent on host B cell and antibody responses.

PI_NAMEs: CANNON, MARTIN J (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: anti-PD-1;anti-PD1 therapy;Antibodies;Antibody Response;Antigen Targeting;Ascites;B-Cell Activation;B-Lymphocytes;BRCA2 gene;cancer immunotherapy;Cancer Patient;Cancer Vaccines;Cell Therapy;checkpoint inhibition;chemotherapy;Clinical;clinically relevant;Combination immunotherapy;combinatorial;cytokine;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;design;Enrollment;Evaluable Disease;experience;Follow-Up Studies;Foundations;Funding;Future;genetic signature;Immune checkpoint inhibitor;Immunity;immunogenicity;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;innovation;Interleukin-10;Interleukin-15;Maintenance;Malignant neoplasm of ovary;MAP Kinase Gene;Melanoma;Morphology;mouse model;Mutation;neoplasm immunotherapy;No Evidence of Disease;novel;Operative Surgical Procedures;Outcome;ovarian neoplasm;overexpression;p38 Mitogen Activated Protein Kinase;Patients;PD-1 inhibitors;pembrolizumab;Phase I Clinical Trials;Phase II Clinical Trials;phase II trial;Prevalence;Publishing;Recurrence;Reporting;response;Role;standard of care;synergism;T cell response;T-Lymphocyte;tertiary lymphoid organ;Testing;TP53 gene;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Vaccine Therapy;Vaccinee

PROJECT_TITLE: Mechanisms of Th17-DC immunotherapy for ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-O (J1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Diabetes;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care

ORG_CITY: ORLANDO

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, ORLANDO

PHR: PROJECT NARRATIVE Most children and adolescents with type 1 diabetes (T1D) do not meet glycemic control recommendations, which places them at risk for developing acute and long-term complications, and up to a third of youth with T1D report elevated depressive symptoms. The proposed research aligns with NIDDK’s mission to improve the health and quality of life of individuals living with diabetes by using a novel single-session intervention (SSI) approach to improve depressive symptoms and glycemic levels in youth with T1D. The proposed research and the career development plan developed by the candidate and mentoring team will result in an innovative T1D-specific depression SSI with the potential to significantly improve health and access to mental health care for adolescents with T1D who report elevated depressive symptoms.

PI_NAMEs: MONZON, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: 18 year old;Acute;Address;Adolescent;Ambulatory Care;Appointment;attentional control;barrier to care;Behavior;Behavior Therapy;career;career development;Caring;Child;Child health care;Childhood;Childhood diabetes;Chronic;Chronic Disease;Clinic;clinical care;Clinical Trials;Complex;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;cost;cost effectiveness;Data;data registry;Depression screen;depressive symptoms;Development Plans;diabetes management;Diabetes Mellitus;efficacy evaluation;efficacy testing;evidence base;experience;Family;Feedback;flexibility;follow-up;Frequencies;glucose monitor;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health;Health Care Costs;Health Personnel;Healthcare;high risk;improved;Individual;innovation;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;intervention delivery;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;knowledge integration;Manuals;Medical;medical appointment;Mental Depression;Mental Health;Mental Health Services;Mentors;Mission;Modeling;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outpatients;Parents;Participant;physical conditioning;pilot test;pilot trial;Process;programs;Provider;psychologic;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk;Site;skills;social stigma;Structure;systemic barrier;Testing;therapy design;Training;Treatment Efficacy;Treatment Protocols;treatment strategy;Visit;Youth

PROJECT_TITLE: Adapting Single Sessions Interventions for Type 1 Diabetes (ASSISTED): Integrated Pediatric Care to Reduce Depression and HbA1c

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative Persisters are bacteria that have a non-inherited ability to tolerate antibiotic treatment, and they are thought to underlie the propensity of many infections to relapse. Recently, we discovered that chromosome copy number (ploidy) impacts the likelihood bacteria would give rise to fluoroquinolone persisters, with monoploids up to 40-fold less likely to be persisters compared to diploids. The research proposed will investigate how ploidy impacts the DNA repair systems persisters use to survive, assess whether ploidy influences the activities of other antibiotics, and identify compounds that can modify ploidy distributions in growth-limited bacteria, which could lead to new antibiotic adjuvants (ploidy modulators) with anti-persister activity.

PI_NAMEs: BRYNILDSEN, MARK P (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Address;Adjuvant;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteria;Biological Assay;Carbenicillin;cell fixing;Cells;Chemicals;Chromosomes;Chronic;chronic infection;Ciprofloxacin;Clinical;Cycloserine;Data;de novo mutation;Development;Diploidy;DNA;DNA Damage;DNA metabolism;DNA Repair;DNA-Directed RNA Polymerase;drug repurposing;druggable target;ds-DNA;Enzymes;Escherichia coli;Exonuclease;experience;experimental study;FDA approved;Flow Cytometry;Fluorescence Microscopy;Fluorescence-Activated Cell Sorting;Fluoroquinolones;Fosfomycin;Fostering;Gastrointestinal tract structure;Growth;Health;homologous recombination;Impairment;improved;Individual;Infection;Knowledge;Laboratories;Levaquin;Libraries;Measures;Modeling;Moxifloxacin;mutant;Nitrofurantoin;Nucleic Acids;pathogen;Phase;Phenotype;PicoGreen;Ploidies;Polyploidy;Population;population based;Proteins;recurrent infection;Relapse;repaired;Reporter;Reporting;Research;Resistance development;response;Rifampin;rifaximin;scaffold;segregation;small molecule libraries;Sorting;SOS Response;Stains;Stress;stress tolerance;System;Testing;tool;Trimethoprim-Sulfamethoxazole;Urinary tract infection;Variant;Work

PROJECT_TITLE: Investigating ploidy modulation as a strategy to improve antibiotic activity

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Sexually Transmitted Infections;Social Determinants of Health

PHR: PROJECT NARRATIVE This research will produce novel point-of-care assays to diagnose N. gonorrhoeae infection and predict AMR. Our work will also provide valuable insights into the genomic epidemiology of resistance mutations in N. gonorrhoeae as well as inform future efforts to implement POC testing for STI in low-resource settings. In so doing, our work will support the introduction of resistance-guided therapy in areas previously limited to syndromic management of STI, combating the global public health threat of AMR N. gonorrhoeae.

PI_NAMEs: ALLAN-BLITZ, LAO-TZU  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;adverse outcome;Africa;Agreement;Anti-microbial susceptibility;Antibiotics;Antimicrobial Resistance;Area;assay development;Automobile Driving;Bioinformatics;Biological Assay;Blindness;Botswana;career;career development;Cefixime;Cephalosporin Resistance;Cephalosporins;Ciprofloxacin;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collaborations;cost;CRISPR/Cas technology;Data;design;Detection;detection assay;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic technologies;Diagnostic tests;Disease Surveillance;DNA Gyrase;DNA sequencing;Drug-resistant Neisseria Gonorrhoeae;emerging antimicrobial resistance;Enzymes;Epidemiology;Evaluation;experience;Fluorescence;Future;General Hospitals;Generations;Genes;Genetic;genome sequencing;genomic epidemiology;Genotype;Goals;Gonorrhea;Health;health disparity;health inequalities;HIV Infections;Hospitals;implementation science;improved;In Vitro;in vitro Assay;Infection;Infertility;Infrastructure;innovation;insight;instructor;interest;isothermal amplification;Laboratories;laboratory experience;lateral flow assay;Massachusetts;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metagenomics;Methods;microbial genomics;Microfluidics;Molecular;molecular marker;Mutation;Neisseria gonorrhoeae;Neonatal;novel;novel diagnostics;novel strategies;Nucleic Acid Amplification Tests;Orthologous Gene;Pathogen detection;Patients;Pelvic Inflammatory Disease;Performance;Phenotype;point of care;point of care testing;point-of-care detection;predictive test;Predisposition;Preparation;pressure;Provider;Public Health;Publications;Reporter;Research;Research Infrastructure;Research Priority;Resistance;resistance mutation;Resource-limited setting;Risk;Sampling;scale up;Scientist;Sexual Health;Sexually Transmitted Diseases;Specimen;Techniques;Technology;Test Result;Testing;Training;United States National Institutes of Health;whole genome;Woman;Work

PROJECT_TITLE: The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Most transgender men using testosterone gender-affirming hormone therapy develop vaginal atrophy and have a non-Lactobacillus dominated vaginal microbiota (i.e., vaginal dysbiosis). This study will investigate if testosterone use and vaginal atrophy severity are associated with vaginal microbiota composition, taxonomic diversity, or vaginal infections. This research will fill a critical gap in our understanding of the gynecological health of transgender men using testosterone and support the development of culturally-tailored, evidence- based interventions to prevent and treat vaginal atrophy, vaginal dysbiosis, and vaginal infections in this population.

PI_NAMEs: TORDOFF, DIANA MARIE (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Aerobic;Atrophic;Attitude;Bacterial Vaginosis;Bioinformatics;Biological;Biological Factors;career;career development;Caring;cis-female;Clinical;Clinical Trials;cohort;community engaged research;Complementarity Determining Regions;Control Groups;Cytology;Data;design;Development;Development Plans;dysbiosis;effective therapy;Effectiveness;efficacy evaluation;Environment;Epidemiologic Factors;Epidemiology;Epithelial Cells;Epithelium;Estrogens;Evidence based intervention;experience;Fostering;Funding;gender affirming hormone therapy;Genitalia;Glycogen;Goals;Gonadal Steroid Hormones;Gynecologic;Health;Healthcare;Hormones;improved;indexing;Infection;innovation;Intervention;Interview;Lactobacillus;Lesbian Gay Bisexual Transgender Queer;Measures;Mediating;Mentors;Mentorship;Methods;microbial community;microbiome research;microbiota;microbiota composition;novel;Participant;pathogen;Personal Satisfaction;Population;population health;Postmenopause;preference;Prevalence;prevent;Probiotics;Production;programs;Qualifying;Questionnaires;recruit;Research;Research Design;Research Infrastructure;Research Personnel;response;Risk Factors;Sampling;Severities;sexual and reproductive health;Sexual Health;social;social factors;Surveys;Swab;Symptoms;Taxonomy;Testosterone;therapy development;Tissues;Training;transgender;transgender men;Translational Research;Universities;Vagina;vaginal infection;vaginal microbiome;vaginal microbiota;Vaginitis

PROJECT_TITLE: The Impact of Testosterone on Vaginal Atrophy and the Vaginal Microbiome in Transgender Men


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Amplification and overexpression of CCNE1, the gene encoding cyclin E1, is frequently observed in aggressive subtypes of ovarian and other cancers and is associated with poor prognosis and resistance to chemotherapy. This project addresses the paucity of therapeutic options for CCNE1-driven tumors by developing first-in-class inhibitors with potential as novel drugs to effectively counteract this aberration.

PI_NAMEs: LOPCHUK, JUSTIN MATTHEW;SCHONBRUNN, ERNST  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Academia;Address;Adopted;Affinity;Allosteric Site;Binding;Biochemical;Cancer Biology;Cancer cell line;Cancer Etiology;Cancer Patient;cancer therapy;CCNE1 gene;CDC2 gene;CDK2 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Line;Cells;Cessation of life;chemotherapy;Clinic;Clinical Treatment;combat;Complex;computer studies;Crystallography;Cyclin-Dependent Kinases;Cyclins;Data;design;Development;Disease;Drug Design;Drug Industry;Drug Targeting;efficacy evaluation;Endometrial Carcinoma;experience;Genes;Goals;Growth;in vivo;inhibitor;innovation;insight;Laboratories;Lead;Ligands;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;Molecular Conformation;mouse model;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;Ovarian;overexpression;patient derived xenograft model;Patients;Pharmaceutical Chemistry;pharmacologic;pharmacophore;Phosphotransferases;Platinum;Prognosis;Property;Protein Kinase;Proteins;rational design;Recurrence;Regulatory Element;Research;Research Personnel;Resistance;Scientist;Series;Serous;Site;small molecule;Structure;Structure-Activity Relationship;targeted treatment;Therapeutic;triple-negative invasive breast carcinoma;tumor;Uterine Cancer

PROJECT_TITLE: Development of bifunctional CDK2 inhibitors for treatment of CCNE1-driven cancers


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed study will evaluate the feasibility and acceptability of “Pain Disengagement Training,” a novel, self-directed intervention for chronic pain. PDT targets pain catastrophizing, including the tendency to magnify the intensity of and ruminate on the experience of pain, which is a key predictor of the extent to which pain interferes in an individual’s life. Due to its self-directed nature, PDT has great potential to reduce the burdensomeness of pain in a large number of patients suffering from this chronic and often disabling condition.

PI_NAMEs: MCDERMOTT, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: GINEXI, ELIZABETH M

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Advisory Committees;Affect;Anxiety;anxiety treatment;Benchmarking;career;Caring;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinical;Clinical Trials;Complementary Health;coping;Data Analyses;design;Development;disability;Disabling condition;Educational Intervention;Evaluation;experience;Facial Pain;feasibility trial;Feedback;Feeling;Focus Groups;Fright;Funding;Future;General Hospitals;Goals;gratitude;Health;Healthcare;Iatrogenesis;Individual;Integrative Medicine;Interdisciplinary Study;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;Language;Life;Maintenance;Manuscripts;Massachusetts;medical schools;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mind-Body Intervention;Modeling;National Center for Complementary and Integrative Health;Nature;novel;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;pain adaptation;pain catastrophizing;Pain intensity;Pain interference;Pain management;Pain Nature;pain patient;pain reduction;Participant;patient population;Patient Self-Report;Patients;Pharmacological Treatment;post intervention;Postdoctoral Fellow;Pragmatic clinical trial;Procedures;Protocols documentation;Psychology;Publications;Qualitative Methods;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Research Design;Research Personnel;Resources;rumination;Sampling;Scientist;Self Direction;Services;Site;skills;Techniques;Testing;therapy development;Training;underserved community;Underserved Population;United States;United States National Institutes of Health;whole health;Writing

PROJECT_TITLE: Pain Disengagement Training: A self-directed intervention for pain catastrophizing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Overall: Project Narrative The MADRC is a Center based at Massachusetts General Hospital, Harvard Medical School, devoted to understanding and ultimately contributing to the cure of Alzheimer’s disease and Related Disorders (ADRD). We support research in tracking the course of several hundred participants with an emphasis on diversity, obtain imaging studies and biofluids to develop biomarkers, and request permission for autopsy. The Center supports both clinical and basic science research, and also is a training environment for scientists and clinician-investigators to “build the future”.

PI_NAMEs: GOMEZ-ISLA, TERESA  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Authorization documentation;Autopsy;Awareness;Basic Science;Behavioral;Big Data;Biological Markers;Blood Vessels;Brain;Brain Pathology;Capital;Caring;Cells;Clinical;clinical phenotype;Clinical Sciences;Clinical Trials;Cognition;Cognitive;cognitive change;cohort;Communication;Communities;community engaged research;community setting;Data;Data Analytics;Dementia;design;Detection;Development;digital phenotyping;Disease;Disease Marker;Disease Progression;Ecosystem;Education;education research;Environment;ethnic diversity;Etiology;Faculty;Faculty Recruitment;frontotemporal degeneration;Frontotemporal Dementia;Future;General Hospitals;Goals;Health Professional;Heterogeneity;Image;imaging study;Imaging Techniques;Impaired cognition;Impairment;improved;Individual;induced pluripotent stem cell;inflammatory marker;Infrastructure;innovation;Institution;Investments;Knowledge;Laboratories;Lead;Leadership;Learning;Lesion;Lewy Body Disease;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;medical schools;Mentors;Mission;Modernization;MRI Scans;multimodal data;Nerve Degeneration;neuroinflammation;neuropathology;next generation;normal aging;novel;novel strategies;outreach;Participant;Pathologic;Patients;Phenotype;Plasma;Play;Population;Positron-Emission Tomography;Process;programs;progression marker;racial diversity;recruit;Research;Research Assistant;Research Personnel;Research Support;Resources;Science;Scientific Advances and Accomplishments;Scientist;single molecule;Symptoms;Synapses;tau Proteins;Techniques;Technology;Testing;Time;tool;Training;Training and Education;Tube;validation studies;Work

PROJECT_TITLE: Massachusetts Alzheimer's Disease Research Center (MADRC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Administrative Supplement;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Back;career development;Charge;Clinical;Clinical Research;Clinical Trials;cohort;Communication;Communities;community advisory board;Data;data repository;Development;Discipline;Disease Marker;Disease Progression;diversity and inclusion;Drug or chemical Tissue Distribution;Education;Ensure;Environment;Event;Faculty;Faculty Recruitment;fighting;Future;Glues;Goals;Grant;human subject;improved;Institution;International;Leadership;Learning;Maps;Massachusetts;Measurement;meetings;Mentors;Minority;Mission;Monitor;new growth;novel;operation;Participant;Patients;Play;Policies;Process;programs;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Running;Sampling;Science;Series;Strategic Planning;symposium;Techniques;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: SERRANO-POZO, ALBERTO  (contact)

PROJECT_TERMS: Acceleration;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid;Autopsy;behavior measurement;Biological Markers;Biology;Black American;career development;Career Mobility;Caregivers;Caring;Clinic;Clinical;clinical care;Clinical Data;clinical diagnosis;clinical phenotype;clinical practice;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive change;cohort;Collaborations;Collection;Communities;Consent;Continuing Education;Cultural Diversity;Data;Dementia;Detection;digital;digital phenotyping;Disclosure;Disease;Disease Marker;Education;education research;Environment;Equity;ethnic diversity;Evaluation;experience;FDA approved;Fostering;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Future;Goals;Healthcare;Hispanic;Human Resources;Image;improved;Individual;individual response;Institution;instrument;Intervention;Intervention Trial;Language;Leadership;Lewy Body Dementia;Lewy Body Disease;Linguistics;Link;Liquid substance;Magnetic Resonance Imaging;Massachusetts;Measures;Medical center;Memory;men;Methods;Minority;Minority Enrollment;Minority Groups;Mission;Monitor;Neurodegenerative Disorders;neuroimaging;neuropathology;Normal Range;novel;Older Population;Participant;patient oriented;Patients;pet animal;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Positron-Emission Tomography;Prevention;Primary Care;Procedures;programs;Protocols documentation;racial diversity;recruit;Research;Research Methodology;Research Personnel;response;Scientist;Source;Spanish;Subgroup;tau Proteins;Testing;Time;Training;Training Support;Translating;translational potential;Translations;Validation;vascular factor;virtual;Visit;Woman;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: DAS, SUDESHNA  (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Bioinformatics;bioinformatics tool;Biological Markers;Clinical;clinical database;Clinical Trials;cohort;Collaborations;Communities;Computer software;Consultations;Data;Data Analyses;data exchange;data integration;data management;data quality;data resource;Data Science;Data Set;Data Sources;Databases;design;Development;Diagnosis;digital;Disease;Early identification;education research;electronic data;Ensure;Epidemiology;explainable machine learning;Faculty;flexibility;Fostering;Free Will;Goals;Image;Impaired cognition;Individual;Informatics;Infrastructure;innovation;Institution;inter-individual variation;International;Internships;investigator training;Laboratories;Link;machine learning algorithm;machine learning model;Massachusetts;Measures;Medical Students;Medicine;Mentors;Methodology;Methods;Modality;Modeling;multimodal data;multiple omics;Natural History;neuropathology;next generation;open source;Participant;Pathway interactions;Persons;Play;predictive modeling;preference;Prognosis;programs;Publications;recruit;Reporting;Reproducibility;Research;Research Design;Research Personnel;research study;Role;Science;Scientist;Secure;Selection Bias;Source Code;statistical and machine learning;statistics;Subjects Selections;symposium;System;Technology;tool;Training;training opportunity;translational scientist;transmission process;undergraduate student;Underrepresented Populations;Visualization;Work

PROJECT_TITLE: Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: FROSCH, MATTHEW P (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Biological;Biological Assay;Brain;brain tissue;Cells;CLIA certified;Clinical;Clinical assessments;clinical training;cohort;Collaborations;Collection;Communities;Consent;Data;Data Collection;data sharing;demented;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Diverse Workforce;Drug or chemical Tissue Distribution;Education;Education and Outreach;Elastic Tissue;Ensure;Environment;experience;Family;Fibroblasts;Future;Health;Heterogeneity;Human;human tissue;Impaired cognition;Individual;induced pluripotent stem cell;insight;Intention;International;Language;Massachusetts;Medicine;Methods;Microscopy;minority communities;Mission;molecular phenotype;Nerve Degeneration;Neurodegenerative Disorders;Neurologist;neuropathology;next generation;novel;Pathologic;Pathologic Processes;Patients;Performance;Physicians;Positioning Attribute;potential biomarker;Process;programs;protein aggregation;Proteomics;Reagent;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Support;Resources;response;RNA;Sampling;Scientist;single nucleus RNA-sequencing;Source;Spanish;Standardization;Symptoms;Tissue Banks;tissue preparation;tissue processing;tissue resource;Tissue Sample;Tissues;Training;Translating;Translations;Validation;Work

PROJECT_TITLE: Neuropathology Core