ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Racial-ethnic segregation exists in multiple forms within ambulatory (outpatient) settings in the US. To eliminate structural racism and discrimination from healthcare, we must identify, quantify, and address the factors that contribute to segregated care, and design strategies to eliminate practice segregation. Our study leverages a natural experiment underway as an Anti-Racism Roadmap is implemented across a large health system. First, we will describe the level of segregation in NYC hospital affiliated ambulatory practices and examine the associations between the level of segregation and selected quality measures of care. We will then look regionally, at the relationship of segregation, practice characteristics and perceived racism within the largest academic center in NYC. Finally, we will observe the impact of implemented equity interventions, barriers and facilitators of clinic unification and explore their potential societal impact on health.

PI_NAMEs: BICKELL, NINA A. (contact);HOROWITZ, CAROL R;RICHARDSON, LYNNE D.

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;Ambulatory Care;anti-racism;Appointment;Area;Attention;billing data;Black race;Black, Indigenous, People of Color;bundled payment;cardiometabolism;care delivery;care outcomes;Caring;Characteristics;Chronic Disease;Clinic;Clinical;clinical practice;Clinical Research;Compensation;Complex;Data;Desegregation;design;Dimensions;Discipline of obstetrics;Discrimination;Disease Management;Disparate;Economics;Education;Educational process of instructing;Equity;ethnic minority;Ethnic Origin;ethnic segregation;Evaluation;experience;Faculty;Family Practice;Geographic Locations;Health;Health Policy;Health system;Healthcare;Healthcare Systems;Hospitals;Hour;indexing;Indigent;Individual;Institution;Insurance;Intervention;Interview;Latinx;Laws;Legal;Length;Maintenance;Measures;Medicaid;Medical;Medical Education;Medical Residency;medical specialties;medically underserved population;Modeling;models and simulation;Natural experiment;New York City;Observational Study;Occupational;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Pediatrics;perceived discrimination;Perception;Physicians;Policies;Population;Prejudice;Preventive care;Preventive measure;Process;programs;prospective;Provider;Quality of Care;Race;racial disparity;racial minority;Racial Segregation;racism;Reimbursement Mechanisms;Research;residential segregation;Resources;Sampling;segregation;Services;simulation;Site;social group;Societies;Socioeconomic Status;Specific qualifier value;Structural Racism;Structure;Students;Surveys;System;Techniques;Time;Training;Uninsured;Urban Hospitals;Visit;Wait Time

PROJECT_TITLE: DiSRUPT: Dismantling Structural Racism Underlying the Organization of Ambulatory PracTices: an observational study of clinical desegregation


ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Machine Learning and Artificial Intelligence;Neurosciences;Precision Medicine;Substance Misuse

ORG_CITY: STRASBOURG

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: UNIVERSITE DE STRASBOURG

PHR: NARRATIVE In the past period, we established mouse MRI is a feasible approach to establish fingerprints for both structural and functional adaptations of the whole brain connectome to alcohol exposure. Here we will expand this methodology and develop new analytic methods to answer three questions: (i) do alcohol fingerprints differ along the drinking trajectory, and between sexes? (ii) can we classify and predict drinking behavior and drug effects for individual subjects from MRI? and (iii) can we bridge MRI data with molecular immune brain mapping (INIA synergy)?

PI_NAMEs: HARSAN, LAURA ADELA (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Agonist;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;analytical method;Behavior;behavior prediction;Behavioral;Biological Markers;Brain;brain magnetic resonance imaging;Brain Mapping;brain morphology;C57BL/6 Mouse;Classification;Communication;connectome;connectome data;Data;design;Diagnostic;Diffusion Magnetic Resonance Imaging;drinking;drinking behavior;experimental study;Extracellular Matrix;Female;Fingerprint;FOS gene;functional adaptation;Functional Magnetic Resonance Imaging;Gene Expression;Gene Targeting;Genetic;Goals;Histology;Human;Image;Immune;Individual;innovation;interest;Knockout Mice;Link;Literature;Machine Learning;Magic;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;male;Maps;metabolic profile;metabolomics;Methodology;Microglia;Modeling;Molecular;Morphology;Motivation;mouse model;mu opioid receptors;multimodality;Multiparametric Analysis;Mus;negative affect;neural circuit;neuroadaptation;Neuroimmune;novel;Orphan;Pathway interactions;patient stratification;Pattern;Pharmaceutical Preparations;Pharmacotherapy;predictive modeling;Prefrontal Cortex;Protocols documentation;receptor;Recording of previous events;Research;Research Personnel;Resolution;Rest;Rewards;serial imaging;sex;Shapes;Signal Transduction;Site;Stress;Structure of terminal stria nuclei of preoptic region;synergism;Time;transcriptomics;Treatment Efficacy;Ventral Tegmental Area;Withdrawal;Work

PROJECT_TITLE: 11/11 Connectome-based fingerprinting of alcohol drinking in mice: mechanisms and biomarkers


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Modified Public Health Relevance Section  Errors in chromosome segregation can promote stem cell dysfunction, birth defects and cancer development. Investigation of these kinesins during vertebrate development will determine how cells control polarity during embryonic cell division to facilitate neural development and prevent birth defects.

PI_NAMEs: WORDEMAN, LINDA  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Antineoplastic Agents;ATP phosphohydrolase;Biological Assay;Brain;Cell Culture Techniques;Cell division;cell fixing;Cell Line;Cell Survival;Cells;Centrosome;Chromosomal Instability;Chromosome Segregation;Chromosomes;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;cohesion;Congenital Abnormality;Coupled;CRISPR/Cas technology;Development;Embryo;embryo cell;Embryonic Development;Engineering;Enhancers;Enzymatic Biochemistry;Fluorescence;Fluorescence Microscopy;Functional disorder;Future;Generations;Genome;Geometry;Goals;hatching;Human;Image;Imaging Device;Impairment;Investigation;Kinesin;Kinetochores;knowledge base;Length;Malignant Neoplasms;Microscopy;Microtubules;Mitosis;Mitotic;Motor;mutant;MXD1 gene;nerve stem cell;neurodevelopment;new therapeutic target;overexpression;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phosphotransferases;Positioning Attribute;Predisposition;premature;preservation;prevent;Proteasome Inhibitor;Proteins;public health relevance;Resistance;Role;single molecule;Sirolimus;small molecule;stem cell division;stem cells;targeted agent;Testing;Therapeutic;therapeutic target;Transgenic Organisms;Tubulin;tumorigenic;Vertebrates;Zebrafish

PROJECT_TITLE: Microtubule dynamics and error correction

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Deep brain stimulation (DBS) is used for treatment of Parkinson's disease and many neuropsychiatric disorders. Researchers and clinicians have used 3-dimensional computer models of patient brains (based on their MRI) to predict how far stimulation effects spread around DBS electrode with the goal of understanding which brain areas are important in DBS and to improve DBS programming. We plan to test the accuracy of different DBS models variants by comparing their predictions of neural activations to experimental evoked potential measurements and to clinical side effects in patients with Parkinson's disease.

PI_NAMEs: MIOCINOVIC, SVJETLANA  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Anatomy;Applications Grants;Area;Atlases;Axon;Biomedical Engineering;biophysical model;Biophysics;Brain;Chronic;Clinic;Clinical;clinical development;clinical practice;clinical predictors;Clinical Research;cohort;Computer Models;Contralateral;Data;Deep Brain Stimulation;Development;Distal;driving force;electric field;Electric Stimulation;Electrical Stimulation of the Brain;Electrodes;Electrophysiology (science);Encapsulated;Evoked Potentials;experimental study;Face;Goals;Human;Image;Implant;improved;in vivo;individual patient;insight;Limb structure;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;model development;Modeling;models and simulation;Motor;Motor Evoked Potentials;multidisciplinary;Muscle;neural;Neural Pathways;neural stimulation;Neurons;neuropsychiatric disorder;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;Patients;Pattern;Peripheral;Physiologic pulse;Positioning Attribute;Postoperative Period;predictive modeling;recruit;Research;Research Personnel;Research Project Grants;response;side effect;simulation;Source;Stimulus;Structure;Surveys;System;Testing;Tissues;Variant;Visual;Width

PROJECT_TITLE: Optimizing Patient-Specific Deep Brain Stimulation Models Using Electrophysiology

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

ORG_STATE: CO

PHR: Project Narrative Body art has experienced a steady increase in popularity in the U.S., leading to many jurisdictions rapidly enacting new regulations. Environmental health professionals are responsible for inspecting facilities to meet regulatory requirements, but there is a proven lack of comprehensive education and training, making inspections a learn-as-you-go process. The proposed Body Art Training Development Workshops, utilizing industry knowledge and regulatory experience, will develop training programs to provide a consistent, informed approach to the inspection of body art facilities.

PI_NAMEs: BAKER, RANCE  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: National Environmental Health Association (NEHA) Body Art Training Updates and Delivery


ADMINISTERING_IC: DE

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: The neural crest gives rise to most of the skeletal elements of the face and is implicated in many congenital birth defects. Expanding our understanding of molecular programs controlling neural crest formation will provide insight into the genetic basis of craniofacial disease. Novel mechanisms uncovered in this work may have important implications for the diagnosis and treatment of craniofacial defects.

PI_NAMEs: ROTHSTEIN, MEGAN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Automobile Driving;Binding;Biochemical;Birds;bone;Bone Tissue;Cartilage;Cell Differentiation process;cell type;Cells;Cephalic;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Complex;Congenital Abnormality;Connective Tissue;Consensus;craniofacial;Craniofacial Abnormalities;Craniosynostosis;Data;Development;Diagnosis;Dimerization;Disease;Dissection;Elements;embryo cell;Enhancers;Environment;epigenomics;Etiology;Event;experimental study;extracellular;Face;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;genome wide association study;Genomic Segment;Genomics;Human;insight;Ligands;Link;loss of function;MADH2 gene;Mediating;migration;Molecular;Morphogenesis;Mus;Mutate;Neural Crest;Neural Crest Cell;neuroregulation;Neurula;novel;Nuclear;Oral;Pathology;Peptide Initiation Factors;Phase;Play;Population;premature;Process;programs;Proteins;Proteomics;Regulatory Element;Research;Role;Shapes;Signal Transduction;single cell analysis;single cell ATAC-seq;skeletal;Skeleton;Specific qualifier value;Specificity;stem cells;Stimulus;Structure;System;Testing;TFAP2A gene;TFAP2B gene;TFAP2C gene;transcription factor;Transforming Growth Factor beta;Validation;Work

PROJECT_TITLE: Cis regulatory control of avian bill morphogenesis

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Glioblastoma (GBM) is one of the most devastating human cancers that almost always recurs due to the presence of invasive therapy-resistant infiltrating cancer cells at the tumor margin. Magnetic hyperthermia therapy (MHT) is a powerful, nanotechnology-based treatment that may enhance the effects of radiation therapy (RT) and chemotherapy against infiltrating GBM tumors.

PI_NAMEs: HADJIPANAYIS, CONSTANTINOS GEORGE (contact);IVKOV, ROBERT

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Adjuvant Therapy;Aftercare;Animal Model;Animals;antitumor effect;Autopsy;bioluminescence imaging;Brain;Brain Neoplasms;brain tissue;cancer cell;Canis familiaris;Cell Death;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Computer Models;Data;Deposition;design;DNA Double Strand Break;Dose;effective therapy;Effectiveness;European;Excision;Exposure to;External Beam Radiation Therapy;Finite Element Analysis;Formulation;Foundations;fractionated radiation;Generations;Glioblastoma;Glioma;Heat shock proteins;Heating;Histopathology;Human;Hyperthermia;hyperthermia treatment;hyperthermia tumor treatment;Image;image guided;imaging modality;improved;Infiltration;Injections;innovation;Iron;iron oxide nanoparticle;magnetic dipole;magnetic field;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Methodology;Modeling;Mus;nanoparticle delivery;Nanotechnology;neoplastic cell;Normal Cell;Normal tissue morphology;Oral Administration;Oryctolagus cuniculus;Patients;Penetration;Pilot Projects;Prognosis;radiation effect;Radiation therapy;Recurrence;Rodent;Safety;safety and feasibility;Solid;Study of magnetics;Technology;temozolomide;Temperature;therapy resistant;tissue injury;Tissues;tool;Toxic effect;translation to humans;translational applications;translational potential;Treatment Efficacy;treatment planning;treatment response;tumor;Tumor Debulking;tumor microenvironment;Work

PROJECT_TITLE: Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-E(02)M]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE  The goal of this project is to characterize the neurodegeneration in and determine the mechanism of survival of a new knock-in rat model of the Alzheimer disease-associated L435F mutation in Presenilin 1. The novel report of the survival of these rats, despite a γ-secretase loss of function phenotype, will allow for a more precise investigation of the role of Presenilin 1 in neurodegeneration that is available with current animal models. The findings from our proposed studies will broaden our understanding of the causes of neurodegeneration in Alzheimer's disease.

PI_NAMEs: TAMBINI, MARC D (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adult;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;amyloid precursor protein processing;Animal Model;attenuation;Autophagocytosis;Behavior;behavior test;Behavioral;Biochemical;Biological Assay;Brain;C-terminal;Cannulations;career;Collection;Cytotoxic agent;Dementia;design;Disease;disease model;disease-causing mutation;Drug Delivery Systems;Elderly;Embryo;Endosomes;exosome;Functional disorder;gamma secretase;Generations;Genes;Genetic;genetic information;Genetic Transcription;Genome;Goals;Human;Impairment;In Vitro;Intelligence;Investigation;Knock-in;Knock-in Mouse;Knockout Mice;Learning;loss of function;Measures;Mediating;Memory;Metabolism;Methods;model organism;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neurogenesis;neuroinflammation;neuron loss;Neurons;NFIC gene;novel;Operative Surgical Procedures;overexpression;Pathology;Patients;Perinatal mortality demographics;Phenotype;Physiological;Postdoctoral Fellow;presenilin;presenilin-1;Production;promoter;Protein Isoforms;protein metabolite;Rattus;Reporting;Risk;RNA Splicing;Rodent Model;Role;Senile Plaques;Source;Swedish mutation;tau Proteins;Testing;Time;time use;Transgenes;Transgenic Organisms;Variant;Work

PROJECT_TITLE: Presenilin Knock-in Rat Model of Neurodegeneration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Peripheral Neuropathy;Rehabilitation;Substance Misuse

ORG_CITY: Somerville

ORG_NAME: MICRO-LEADS, INC.

ORG_STATE: MA

PHR: The FastTrack SBIR seeks to develop HD64, a high-resolution spinal cord stimulation therapy for treating chronic neuropathic pain of the lower extremities, groin, and lower back. The device development will result in a clinical trial in people to demonstrate feasibility and to inform final device design. The proposal will motivate further development and productization of an SCS therapy which can reduce pain and remove the dependence upon chronic opioids.

PI_NAMEs: MCLAUGHLIN, BRYAN L (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Action Potentials;Acute;addiction;Animals;Back;biomaterial compatibility;Cadaver;Capital;Chronic;chronic neuropathic pain;chronic pain;Clinical;Clinical Trials;cognitive function;commercialization;Computer software;Contracts;debilitating pain;Dependence;design;design verification;Development;Device Designs;Device or Instrument Development;Devices;dorsal column;dorsal horn;Electric Stimulation;Electrodes;Electromyography;Electronics;Electrophysiology (science);Employment;Ensure;Etiology;Family Felidae;Feasibility Studies;Feedback;Fiber;Foot Pain;Geometry;High Prevalence;Human;human subject;Implant;improved;Inguinal region;Injury;Institutional Review Boards;Intractable Pain;knee pain;Label;Lateral;Lead;Letters;Limb structure;Longevity;Longitudinal Studies;Lower Extremity;manufacture;Manufacturer;Maps;Measures;Mechanics;Medial;Medical center;meetings;Mental Depression;Mental Health;Morbidity - disease rate;Nerve Root Compressions;neural;Neurostimulation procedures of spinal cord tissue;non-opioid analgesic;novel;operation;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid abuse;opioid use;Overdose;Pain;pain reduction;pain relief;painful neuropathy;Paralysed;Patients;Performance;Persons;Phase;Physiologic pulse;pilot test;Positioning Attribute;prescription opioid;programs;Protocols documentation;Quality of life;Resolution;Risk;Running;Safety;safety study;safety testing;Shapes;Sheep;Small Business Innovation Research Grant;Specificity;Spinal;Spinal Cord;Spinal Ganglia;spinal nerve posterior root;Sterilization;Structure;success;Suicide;Technology;Testing;Thick;Tissues;Validation;Width;wireless;Work;Writing

PROJECT_TITLE: High-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain


PHR: Project Narrative NEHA proposes to apply awarded funding towards three projects related to an online workshop series that supports State, Local, Tribal, and Territorial (SLTT) agencies’ Self-Assessment and Verification Audit process, which in turn assists them in their conformance with FDA’s Voluntary National Retail Food Regulatory Program Standards (VNRFRPS, henceforth Retail Program Standards). These projects will serve approximately 900 Retail Program Standards enrollees and will include continuous improvement updates to existing content to align with updates to the Retail Program Standards, development of an entry-level course for professionals new to the Retail Program Standards, and production of a risk-based retail food safety inspection film.

PROJECT_TITLE: Voluntary National Retail Food Regulatory Program Standards Self-Assessment & Verification Audit Online Workshop


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative The identification of new regulators and/or signaling pathways triggered by Taxol will shed light on the mechanisms underlying chemoresistance. Our study identifies the FGFR4 signaling as a potential therapeutic target and suggests that combining inhibitors of FGFR4 with Taxol will have enhanced efficacy in the treatment of Taxol-resistant and/or recurrent patients.

PI_NAMEs: DONG, JIXIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: anti-tumor agent;Biochemical;cancer cell;Cancer Patient;cancer recurrence;cancer therapy;cancer type;Cell Death Induction;Cells;Chemoresistance;chemotherapy;Clinic;Clinical;clinical development;Clinical Trials;cytotoxicity;Data;Development;Drug resistance;drug sensitivity;Family;fibroblast growth factor receptor 4;improved;In Vitro;in vivo;inhibitor;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Molecular;mortality;new therapeutic target;novel;Outcome;Paclitaxel;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phospho-Specific Antibodies;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Prognostic Marker;protein degradation;Protein Family;protein function;Protein Tyrosine Kinase;Recurrence;Regulation;Resistance;response;Role;screening;Signal Pathway;Signal Transduction;Stress;success;Testing;Therapeutic;therapeutic target;Translating;Tubulin;tumorigenesis;Tyrosine Kinase Inhibitor;Ubiquitin

PROJECT_TITLE: Targeting FGFR4 to overcome chemoresistance in ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (O1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Hodgkin's Disease;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE: Sharon Castellino, MD, MSc is an experienced and productive Clinical Scientist whose goal is to improve survival for children, adolescents, and young adults (AYAs) with blood cancers and lymphoma. The R50 award will support her leadership in the Children’s Oncology Group to bring curative therapies and accelerate the timeline for trials with novel agents to AYA with Hodgkin lymphoma. At the institutional level, as the leader of the pediatric leukemia and lymphoma program, the R50 support will enable her to create an AYA trial enrollment infrastructure and minority populations otherwise under-represented on NCI clinical trials in Georgia.

PI_NAMEs: CASTELLINO, SHARON MARIE (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Adult Lymphoma;Aftercare;Antibody-drug conjugates;Award;biobank;Biology;Cell Therapy;cellular targeting;Chemotherapy and/or radiation;Child;Childhood;Childhood Leukemia;Childhood Lymphoma;Clinical;Clinical Research;Clinical Trials;collaborative trial;curative treatments;Data;Data Commons;epidemiologic data;Ethnic Origin;experience;follow-up;Goals;Hematological Disease;Hematopoietic Neoplasms;Hispanic;Hodgkin Disease;Immunotherapy;improved;Incidence;Infrastructure;Institution;Lead;Leadership;leukemia/lymphoma;Link;Lymphoma;Malignant Neoplasms;Minority Groups;Morbidity - disease rate;novel;novel therapeutics;older adult;Patients;Pediatric Oncology Group;Positioning Attribute;Productivity;programs;Race;Recurrent disease;Refractory Disease;Regimen;Relapse;response;Risk;risk stratification;Role;Scientist;Specialist;success;survivorship;Time;timeline;Tissues;TNFRSF8 gene;Translational Research;trial design;trial enrollment;tumor microenvironment;Work

PROJECT_TITLE: Advancing novel therapeutics and translational science to close the survivorship gap in pediatric, adolescent and young adult (AYA) lymphoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O1)]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Orphan Drug;Prevention;Rare Diseases;Rural Health;Vaccine Related

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The Clinical Trials Offices (CTO) at many cancer centers focus on cancer treatment trials but not on cancer prevention trials that target high-risk populations but without active cancers. Establishing and refining current processes around CTO’s cancer prevention trials could bolster NCI’s efforts at cancer prevention.

PI_NAMEs: BANSAL, AJAY  (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Award;Biological Markers;Brachyury protein;Cancer Center;Cancer Control;Cancer Control Research Program;cancer prevention;Cancer Prevention Trial;cancer therapy;Cancer Vaccines;Caring;Clinical;clinical care;Clinical Trials;Comprehensive Cancer Center;Faculty;Funding;Gastroenterologist;Goals;Growth;Health;Hereditary Nonpolyposis Colorectal Neoplasms;high risk population;Home;Image;Improve Access;improved;Kansas;Latino;Lead;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;Messenger RNA;Michigan;Minority Recruitment;Mucin 1 protein;Names;Oncology;Participant;Pathway interactions;patient population;Patients;Phase;Phase II Clinical Trials;Physicians;Prevention program;Prevention Research;Prevention trial;Principal Investigator;Process;process improvement;programs;Provider;Publishing;recombinant adenovirus;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Sharing;retention rate;Rural Population;rural underserved;Scientist;Structure;success;Training;Translational Research;treatment trial;Universities;Vaccines

PROJECT_TITLE: Improving the Processes around Approval, Accrual and Translational Research in Cancer Prevention Trials


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative: Glioblastoma (GBM) is a highly resistant and deadly cancer despite advances in cancer therapeutics. Understanding and overcoming mechanisms of therapeutic resistance in GBM is paramount to improving GBM outcomes. These studies are therefore, designed to examine and target malignant clonal evolution mechanisms in GBM with novel therapies.

PI_NAMEs: ETAME, ARNOLD  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: activity-based protein profiling;Address;Apoptosis;Biological;Biological Assay;BIRC3 gene;cancer stem cell;Cell Survival;Cells;ChIP-seq;Clonal Evolution;combinatorial;Combined Modality Therapy;Complex;design;DNA Repair;Drug Interactions;Drug Kinetics;Drug Screening;Evolution;experimental study;FRAP1 gene;Genes;Genetic;Glioblastoma;Goals;Grant;Histologic;Human;Hypoxia;imaging system;Immunoprecipitation;improved;In Vitro;in vivo;indexing;inducible gene expression;Induction of Apoptosis;inhibitor;innovation;insight;live cell imaging;Malignant - descriptor;Malignant Neoplasms;Mediating;Mesenchymal;Modeling;Molecular;Mus;mutant;novel;novel therapeutics;Nuclear Translocation;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;prevent;Proliferating;Proteomics;Publishing;Radiation therapy;reconstitution;Resistance;Role;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;STAT3 gene;stem cell model;stem cells;stemness;synergism;System;Techniques;temozolomide;Therapeutic;therapy development;therapy resistant;Tissues;translational therapeutics;United States National Institutes of Health;upstream kinase;Validation;Visual;Work

PROJECT_TITLE: Targeting Malignant Reprogramming of Glioblastoma Stem Cells Through Dual Inhibition of S6K1 and BIRC3

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: ABO(H) blood group antigens were the first human polymorphisms described and corresponding anti-ABO(H) antibodies continue to be the most common immunological barrier to transfusion and transplantation. However, despite their discovery over a century ago, the factors that govern the development of anti-ABO(H) antibody and the consequences of ABO(H) incompatibility remain relatively unknown. Using a series translational studies coupled with a new preclinical model of anti-blood group antibody formation, this overarching program project grant (PPG) will define key factors that govern ABO(H) immunity and incompatibility.

PI_NAMEs: STOWELL, SEAN R (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: ABO blood group system;Agglutination;Alloantigen;Antibodies;Antibody Formation;Antibody Specificity;Antigen Targeting;Antigens;Area;B-Lymphocytes;Blood Donations;blood group;Blood Group Antigens;Blood typing procedure;carbohydrate structure;Carbohydrates;Cells;Clinical;clinically relevant;clinically significant;Collaborations;Coupled;design;Development;Disparate;experience;Exposure to;fabrication;Galactose Binding Lectin;Genetic Polymorphism;Glycobiology;Goals;Hematology;Human;human subject;Immune;Immunity;Immunologic Factors;Immunologics;Immunology;Individual;Isoantibodies;Lampreys;Lipopolysaccharides;Mediating;Microbe;microbial;microbial community;Microbiology;Modeling;Modification;Natural Immunity;Nature;novel;novel strategies;Outcome;Paper;Patients;Physicians;Polysaccharides;Population;Post-Translational Protein Processing;Pre-Clinical Model;Program Research Project Grants;programs;Reaction;Reagent;Recording of previous events;Regulation;Scientist;Series;Specificity;Structure;Technology;Testing;tool;Transfusion;transfusion medicine;translational study;Transplantation

PROJECT_TITLE: Leveraging New Approaches to Unravel ABO Blood Group Immunity and Incompatibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 PPG-C (O2)]


PHR: Narrative: Given the complexity of anti-ABO(H) antibody formation and the distinct ABO(H) targets responsible for the outcome of ABO(H) incompatible transfusion, defining the key factors that drive anti-ABO(H) antibody formation and the specific ABO(H) targets on the surface of RBC responsible for hemolytic transfusion reactions will require a multidisciplinary approach that includes investigators with expertise in microbiology, immunology, glycobiology and transfusion medicine. Core A will oversee this multidisciplinary team, while also centralizing all human subject studies, data storage and logistical operations for the entire PPG research program.

PROJECT_TERMS: ABO blood group system;Accounting;Address;Alloimmunization;Antibodies;Antibody Formation;Antibody Specificity;Antigen Targeting;Antigens;Biological Specimen Banks;Biometry;Biostatistics Core;Blood Group Antigens;Collection;Communication;Complex;Consent;Data;data access;Data Analyses;Data Collection;Data Coordinating Center;data hub;data integration;data repository;data sharing;Data Storage and Retrieval;Development;Discipline;Elements;Ensure;Erythrocytes;expectation;Faculty;Glycobiology;Group Structure;Hospitals;Human;human subject;IACUC;Immune;Immunity;Immunologic Factors;Immunology;Individual;Infrastructure;Institutional Review Boards;interdisciplinary approach;interest;medical schools;meetings;Microarray Analysis;microbial;Microbiology;microbiome;Monitor;multidisciplinary;novel strategies;Nursing Research;open data;operation;Outcome;Pathway interactions;Patients;Physicians;Play;Polysaccharides;pre-clinical;Program Research Project Grants;programs;Protocols documentation;Reaction;repository;Research Activity;Research Personnel;Role;Safety;sample collection;Scientist;Shapes;skills;Specificity;Specimen;Statistical Data Interpretation;Study Subject;Surface;tool;Training;Transfusion;transfusion medicine;United States National Institutes of Health;volunteer;Woman;Work

PROJECT_TITLE: Core A - Administration core


PHR: Narrative (Core B): Naturally occurring anti-ABO(H) antibodies, which represent the most common immunological barrier to transfusion and transplantation, can vary in titer and specificity, resulting in distinct clinical outcomes. Importantly, formation of these antibodies is directly linked to host interaction with specific microbial strains that express blood group carbohydrate antigens. The overarching goal of Core B is to provide tools that facilitate assessment of the role of microbial populations in driving and shaping naturally occurring anti- blood group antibody responses and their clinical consequences. To this end, we will provide microbial arrays for the high throughput analysis of both innate and adaptive immune interactions relevant to anti-ABO(H) antibody formation.

PI_NAMEs: ARTHUR, CONNIE M (contact)

PROJECT_TERMS: ABO blood group system;Antibodies;Antibody Formation;Antibody Repertoire;Antibody Response;Antigens;Area;Assessment tool;Automobile Driving;Binding;Biomedical Research;blood group;Blood Group Antigens;Blood typing procedure;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Clinical;Complex;Complex Mixtures;Data;Development;Exposure to;Galactose Binding Lectin;Goals;Group Structure;high throughput analysis;host-microbe interactions;Immune;Immunity;Immunologic Factor Interaction;Immunologic Factors;Immunologics;Individual;insight;Ligands;Link;Mediating;Microbe;microbial;microbial community;microbial host;microorganism interaction;novel;novel strategies;Outcome;Play;Polysaccharides;Population;Printing;Production;Program Research Project Grants;programs;Protein-Carbohydrate Interaction;Proteins;Reproducibility;Resources;Role;Sampling;Shapes;Site;Specificity;Testing;tool;Transfusion;Transplantation;Triage;Validation;Variant

PROJECT_TITLE: Core B - Microbial glycan microarray core


PHR: Narrative: ABO(H) blood group antigens were the first human polymorphisms described and corresponding anti-ABO(H) antibodies continue to be the most common immunological barrier to transfusion and transplantation. However, despite their discovery over a century ago, the factors responsible for anti-ABO(H) antibody development remain relatively unknown. Using a series translational studies coupled with a new preclinical model of anti-blood group antibody formation, we will define key factors that influence the development of anti-ABO(H) antibodies.

PROJECT_TERMS: ABO blood group system;Address;Adult;Antibodies;Antibody Formation;Antigens;B-Lymphocytes;Blood;Blood donor;blood group;Blood Group Antigens;Blood typing procedure;carbohydrate structure;CD4 Positive T Lymphocytes;Cell Count;Cells;Clinical;Communicable Diseases;Coupled;Cues;Data;Development;Enzymes;Excision;Exposure to;Generations;Genetic Models;Genetic Polymorphism;Goals;Hemolysis;Human;human subject;Immune;Immunity;Immunoglobulin M;Immunoglobulin-Secreting Cells;Immunologics;imprint;Individual;Infant;insight;Klebsiella pneumoniae;Knock-out;Life;Medicine;Microbe;microbial;microbial colonization;microbiota;Modeling;Mus;novel;novel strategies;Organ Transplantation;Population;Pre-Clinical Model;Process;programs;Proliferating;Reaction;Role;Series;Sorting;Structure;Testing;Transfusion;translational study;Transplantation;vaccine development;Welding

PROJECT_TITLE: Project 1 - Examining the impact of microbial dynamics on B cells responsible for anti-blood group antibody formation


PHR: Narrative: Anti-ABO(H) antibodies, which form spontaneously within the first few months of life, represent the most common immunological barrier to transfusion and transplantation. However, these antibodies can vary widely between individuals, with significant differences in the levels and specificity of anti-ABO(H) antibodies that can have direct clinical consequence on ABO(H) incompatible outcomes. This study will define the fundamental role of innate immune factors in shaping the levels of blood group positive microbes and the ability of these microbes to impact the levels, specificity and overall hemolytic activity of anti-ABO(H) blood group antibodies.

PROJECT_TERMS: ABO blood group system;Antibodies;Antibody Formation;Antibody Repertoire;Antigens;antimicrobial;B-Lymphocytes;Binding;blood group;Blood Group Antigens;Blood typing procedure;Carbohydrates;Cell surface;Cessation of life;Clinical;Clinical Research;clinically relevant;Communities;conditional knockout;Coupled;Data;Development;Erythrocyte Transfusion;Erythrocytes;Exposure to;Family member;Galactose Binding Lectin;human subject;Immune;Immunity;Immunologic Factors;Immunologics;In Vitro;in vivo;Individual;inhibitor;insight;Intestinal Mucosa;Knockout Mice;Life;Lipopolysaccharides;Mediating;Medicine;Microbe;microbial;microbial community;microbiota;Modeling;Mus;Natural Immunity;novel strategies;Outcome;Polysaccharides;Pre-Clinical Model;preclinical study;prevent;Proteins;Regulation;Role;Series;Shapes;Source;Specificity;Surface;Testing;Transfusion;Transplantation

PROJECT_TITLE: Project 2 - Convergence of innate immunity and microbial communities in the regulation of anti-blood group antibody development


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Degeneration of the retina is one of the leading causes of blindness in developed countries. With defects in more than 280 genes that are known to result in retinal degeneration, there is a critical need to develop therapies that are broadly effective regardless of the gene defect. This study proposes to use a modified arrestin1 protein to directly increase the glycolysis in rod and cone photoreceptors as a mechanism to improve their function and survival, slowing retinal degeneration and delaying the loss of vision.

PI_NAMEs: SMITH, W CLAY (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adopted;Animal Model;Animals;Arrestins;autosome;base editing;Binding;Blindness;Cells;Ciliary Neurotrophic Factor;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cone;cytokine;Data;Defect;design;Developed Countries;Development;Disease;disease-causing mutation;Disinhibition;Dose;efficacy testing;enolase;Enzymes;Etiology;experimental study;gene editing technology;Gene Expression Profile;Gene Mutation;Gene therapy trial;Genes;Genetic;Glucose;Glycolysis;high throughput screening;Human;human tissue;improved;inherited retinal degeneration;Insulin;Kinetics;Libraries;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;Molecular Evolution;mouse model;Muller's cell;mutant;Mutation;Pathway interactions;Photoreceptors;pre-clinical;Process;Production;Property;protective factors;Proteins;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Rhodopsin;Rod;Scientist;success;Therapeutic;therapeutic evaluation;therapy development;tool;Transcriptional Regulation;Vertebrate Photoreceptors;Vision

PROJECT_TITLE: A modified arrestin1 to enhance glycolysis in photoreceptors as a therapeutic approach to slowing retinal degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Mitochondria constitute 30-40% of heart weight and metabolize fats, and proteins and sugars to generate ATP that powers cardiac contraction. Mitochondrial dysfunction contributes to cardiac hypertrophy, heart failure and myocardial infarction. These common heart diseases exhibit a mismatch between metabolic substrate availability and substrate preference: normal mitochondria prefer fats and proteins that most efficiently make ATP, whereas diseased mitochondria reserve fats and protein to repair heart damage and instead metabolize sugars. It was generally accepted that metabolic transitioning in hearts (from preferring fats to sugars or vice-versa) is simply a matter of genetic programming. However, we discovered that the heart must first rid itself of existing mitochondria before replacing them with those having a metabolic preference matching its condition. We identified a key factor responsible for removal, replacement and redistribution of mitochondria during metabolic transitions and developed a new class of drugs to orchestrate and coordinate activities of these factors, matching preferences of the heart’s mitochondria to its available metabolic “menu”. Moreover, by whole genome and exome sequencing we identified rare gene mutations that impair mitochondrial removal and replacement in patients with hypertrophy or heart failure, potentially revealing a new mechanism of heart failure. Our studies provide a fresh understanding of cardiac metabolism and establish the foundation for a completely new approach for managing heart disease by “dialing in” mitochondrial metabolism to optimize cardiac contraction or repair.

PI_NAMEs: DORN, GERALD W. (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adenovirus Vector;Adult;Affect;Automobiles;Basic Science;Biophysical Process;Carbohydrates;Cardiac;Cardiac Myocytes;cardiac repair;cardiogenesis;Cardiomyopathies;Catalogs;Chimeric Proteins;clinical application;Computer software;Disease;disease phenotype;effective therapy;Evaluation;Event;Excision;Exhibits;exome sequencing;Experimental Models;Fatty acid glycerol esters;Fatty Acids;fetal;Foundations;Functional disorder;Gasoline;Gene Mutation;Genetic Programming;genome sequencing;Goals;Growth;Heart;heart damage;Heart Diseases;Heart failure;Heart Hypertrophy;heart metabolism;Heart Mitochondria;Human;Hypertrophy;Impairment;Knock-in Mouse;Learning;Link;Mediating;Metabolic;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial metabolism;Molecular;Molecular Conformation;Motility;mutant;Mutation;Myocardial;Myocardial Infarction;Neurons;Nodal;novel drug class;novel strategies;Parkin;Patients;Pattern;Perinatal;pharmacologic;Phosphorylation;Phosphotransferases;PINK1 gene;pre-clinical;preference;Production;Protein Binding Domain;Proteins;Reagent;repaired;Research;small molecule;Solid;sugar;Therapeutic;Tissues;Translating;Translational Research;Weight;whole genome;Work

PROJECT_TITLE: Mitofusin 2 as a Nodal Regulator of Mitochondrial Function in Cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Infectious Diseases;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Skin-penetrating parasitic nematodes infect over a billion people worldwide and are a major cause of morbidity in low-resource settings. This grant will investigate the behavioral, neural, and molecular mechanisms of gas sensing in the skin-penetrating human parasite Strongyloides stercoralis. Our results will address how these parasites use gas sensing to find and infect humans, which may inform the design of novel anthelmintics.

PI_NAMEs: HALLEM, ELISSA ANYON (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acute;Adult;Afferent Neurons;Ancylostoma (genus);Anthelmintics;Atmosphere;Behavior;Behavioral;behavioral response;Caenorhabditis elegans;Calcium;Carbon Dioxide;carbon dioxide receptor;cellular targeting;Cessation of life;Child;chronic gastrointestinal distress;CRISPR/Cas technology;Cues;design;Development;Distress;Enterobius;Exhibits;experimental study;Family;Feces;functional adaptation;Gases;gastrointestinal;Generations;Genetic;genetic manipulation;Grant;Growth;Growth and Development function;Guanylate Cyclase;Health;Homologous Gene;Hookworms;Human;Image;Impaired cognition;in vivo monitoring;Infection;Infectious Skin Diseases;insight;Interneurons;Intestines;Knowledge;Larva;Life;Life Cycle Stages;Maps;Mediating;Modeling;Molecular;Molecular Target;Morbidity - disease rate;Motility;Mutagenesis;Necator;Nematoda;neural;Neuroanatomy;neuromechanism;Neurons;novel;Oxygen;Parasites;Parasitic nematode;Penetration;Persons;Pharmaceutical Preparations;Process;receptor;Resource-limited setting;response;Sensory;Shapes;Skin;Small Intestines;Soil;Soluble Guanylate Cyclase;Source;Strongyloides stercoralis;Surface;Testing

PROJECT_TITLE: Neural mechanisms of gas sensing in a human-infective worm

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Despite recent advances, treatment of tuberculosis still requires giving 3-4 drugs for a minimum of 4-6 months. New drug candidates with potential to contribute to shorter, simpler treatments are in various phases of research and development but the most efficient path for research studies to determine which new and existing drugs should be combined to create novel regimens with the highest probability of achieving this goal remains uncertain. The overarching objective of this project is to unite a diverse group of researchers, drug developers, research sponsors and other stakeholders to develop and pursue a research agenda to develop a validated pipeline of in vitro and mouse models that will inform mathematical models to predict clinical outcomes and enable early and accurate selection of the most promising new treatment regimens to move into clinical trials.

PI_NAMEs: DOOLEY, KELLY E.;NUERMBERGER, ERIC L;SAVIC, RADOJKA  (contact);SCHNAPPINGER, DIRK

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adult;Age;age related changes;Animal Model;Back;Biological Markers;C3HeB/FeJ Mouse;Child;Childhood;Clinical;Clinical Data;clinical efficacy;clinical translation;Clinical Trials;Collaborations;Communities;cost effective;Critical Pathways;Data;data warehouse;Decision Making;design;Development;Dimensions;Disease;Dose;drug action;drug candidate;Drug Combinations;drug development;drug discovery;drug distribution;Drug Exposure;Drug Interactions;drug metabolism;early detection biomarkers;early phase clinical trial;efficacy study;Equipment and supply inventories;experimental study;forgiveness;genomic platform;Goals;Health;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;Inbred BALB C Mice;Knowledge;Lesion;Linezolid;Link;mathematical model;member;metabolomics;Methodology;Modeling;mouse model;Moxifloxacin;multidisciplinary;Multidrug-Resistant Tuberculosis;Mus;Mycobacterium tuberculosis;Nature;next generation;novel;novel marker;novel therapeutics;Outcome;Output;Oxazolidinones;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Pharmacology;pharmacometrics;Phase;Phase II/III Trial;Phase III Clinical Trials;phase III trial;Phenotype;Play;portability;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical efficacy;preclinical study;predict clinical outcome;Predictive Value;Predisposition;Probability;prospective;Protocols documentation;Provider;Pulmonary Tuberculosis;Pyrazinamide;Regimen;Relapse;Research;research and development;research clinical testing;Research Personnel;research study;Resistance;Resources;Rifamycins;Scientist;simulation;success;Testing;tool;translational model;Translational Research;Translations;treatment duration;treatment optimization;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;Vertebral column

PROJECT_TITLE: Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LG-M (S1)]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Patient Safety;Precision Medicine

PHR: PROJECT NARRATIVE This highly translational study aims to change the paradigm of AE data usage from descriptive summary into modern informative AE biomarkers to fulfill precision medicine.

PI_NAMEs: CHEN, DUNG-TSA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adverse event;Back;Biological Markers;biomarker signature;cancer clinical trial;Categories;Characteristics;chemotherapy;Clinical;clinical practice;clinical predictors;Clinical Treatment;Clinical Trials;clinically relevant;cohort;Cohort Analysis;Cohort Studies;Data;Data Analyses;Development;Drug Evaluation;Early identification;Ensure;experience;Frequencies;Generations;Grouping;Hypertension;Hypothyroidism;immune-related adverse events;Immunotherapy;improved;Individual;ineffective therapies;innovation;insight;Lymphocyte;Malignant neoplasm of lung;Methods;Modernization;neutrophil;Non-Small-Cell Lung Carcinoma;novel;Outcome;Pathway Analysis;patient safety;Patients;Pharmaceutical Preparations;Platelet Count measurement;precision medicine;Precision therapeutics;predict clinical outcome;predictive marker;Predictive Value;prevent;Progression-Free Survivals;PubMed;Reporting;Research;Risk;Risk-Benefit Assessment;Safety;Sample Size;Scientist;survival outcome;System;Testing;Time;tool;Toxic effect;translational study;Treatment Protocols;treatment response;trend;Uncertainty;user-friendly;Validation

PROJECT_TITLE: Development of adverse event (AE) derived biomarkers for predicting clinical outcomes in lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O2)]


ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This program is designed to provide recent college graduates from populations underrepresented (UR) in the biomedical sciences with an intensive research experience, related enrichment activities, and academic advising for a period of one year, possibly longer. The goal of the program is to increase the number of students from UR backgrounds who enroll in a biomedical PhD program and pursue related careers. Ultimately, it is expected that UR biomedical researchers will introduce novel ideas and perspectives from their respective groups into the biomedical workforce, thereby aiding in the reduction of health care disparities.

PI_NAMEs: BHOJ, ELIZABETH JOYCE;KESSLER, DANIEL S (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academic advising;Acquired Immunodeficiency Syndrome;Admission activity;Advocacy;Aging;Bachelor's Degree;Bioinformatics;Biomedical Research;Biometry;career;career networking;college;Communication;community building;Competence;Critical Thinking;design;Development;Development Plans;Doctor of Philosophy;Education;education research;Educational workshop;effectiveness measure;Enrollment;Ensure;Environment;Equity;essays;Evaluation;Evaluation Research;experience;Experimental Designs;Exposure to;Faculty;Fostering;Funding;Goals;graduate school;graduate student;Health;health care disparity;improved;Individual;Institution;interest;Interview;journal article;Journals;knowledge base;Laboratories;Letters;Literature;Measures;meetings;Mentors;novel;Oral;Pediatric Hospitals;peer coaching;Pennsylvania;Philadelphia;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Professional Competence;Program Effectiveness;programs;Qualifying;recruit;Reproducibility;Research;research and development;Research Design;Research Personnel;Research Project Grants;responsible research conduct;role model;Science;skills;Societies;Students;success;symposium;Teacher Professional Development;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Update;Work;Writing

PROJECT_TITLE: UPenn Post Baccalaureate Research Education Program.

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Neurologic illness continues to make up a large burden of the morbidity and mortality of the population in the United States. This need can only be met by continuing to sustain the physician-scientist career pathway to bring innovative translational solutions to neurological health problems. This application looks to renew a highly successful program that leverages the vast resources of the Harvard hospital system and links neurology and neurosurgery trainees with established scientists who have a strong track record of mentorship to foster the careers of the next generation of physician-scientists focused on diseases of the nervous system.

PI_NAMEs: CASH, SYDNEY S (contact);WILLIAMS, ZIV

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: American;Area;biomedical imaging;Boston;Brain;Cardiology;career;Career Choice;career development;Caring;Country;Dana-Farber Cancer Institute;Dedications;Development;Education Projects;Educational Status;equity, diversity, and inclusion;experience;Exposure to;Extramural Activities;Faculty;Feedback;Fellowship;Fostering;Foundations;Funding;Future;General Hospitals;Goals;Grant;Health;Hospitals;improved;Individual;innovation;Institution;Journals;Laboratories;Link;Massachusetts;medical schools;meetings;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Morbidity - disease rate;mortality;National Institute of Neurological Disorders and Stroke;Nature;Nervous System Disorder;Neurologic;Neurology;Neurosciences;Neurosciences Research;neurosurgery;next generation;outreach;Paper;Participant;Pediatric Hospitals;Pediatric Neurology;Physicians;Population;Preparation;Productivity;programs;Psychiatry;Public Health Schools;Publications;Radiology Specialty;recruit;regenerative biology;Research;Research Activity;Research Technics;Research Training;Residencies;Resources;Science;Scientist;Series;stem cell biology;Structure;success;System;Systems Biology;Talents;Therapeutic;Training;Training Programs;translational physician;United States;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Neuroscience Resident Research Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (03)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Unintentional Childhood Injury

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The development and myelination of the central nervous system (CNS) is influenced by the composition of the early cerebrospinal fluid (CSF) environment, which bathes the developing brain in ions and solutes, growth factors, and signaling ligands. The composition of the CSF is controlled primarily by the choroid plexus (ChP), an epithelial-endothelial structure which secretes important enzymes, including Autotaxin (ATX), that instruct the maturation of oligodendrocytes, and therefore, myelination of the CNS. This study will investigate the developmental role of ChP-secreted ATX in regulating myelination and how this may be perturbed in pathologies such as hemorrhage-induced white matter injury associated with hydrocephalus, with the eventual goal of developing a rational intervention strategy for mitigating white matter injury in neonates.

PI_NAMEs: HOCHSTETLER, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Automobile Driving;axon injury;Bathing;Behavioral;Biology;blood product;Boston;Brain;Brain Injuries;brain tissue;career;Caregivers;Cellularity;Central Nervous System;Cerebral Ventricles;Cerebrospinal Fluid;Clinical;Cognitive;Consult;critical developmental period;Cytoplasm;Data;design;Development;Diffusion;druggable target;effective intervention;Endothelium;Environment;Enzymes;Epithelial Cells;Epithelium;experience;Exposure to;Fluid Balance;Future;gain of function;Goals;Growth Factor;Hemorrhage;Histology;Hydrocephalus;Imaging Techniques;improved;in vivo;Incidence;Infant;innovation;Intervention;intraventricular hemorrhage;Ions;Knock-out;Laboratories;Life;Ligands;loss of function;lysophosphatidic acid;Lysophospholipase;Magnetic Resonance Imaging;Measures;Mediating;Mentors;Methods;Modeling;Molecular Biology Techniques;Morbidity - disease rate;mouse model;Mus;Myelin Basic Proteins;myelination;Neonatal;Neonatal Brain Injury;neonate;Nervous System;Neurologic;Neurological outcome;oligodendrocyte progenitor;Oligodendroglia;overexpression;Pathology;Pathway interactions;Patients;Pediatric Hospitals;Perinatal;postnatal;preclinical study;premature;Premature Infant;prevent;Process;Publications;Quality of life;Research;Role;Severities;Shunt Device;Signal Transduction;single nucleus RNA-sequencing;solute;Source;standard care;Standardization;Structure;Structure of choroid plexus;Survivors;Techniques;Therapeutic;Therapeutic Intervention;Tissues;Titrations;Training;treatment strategy;Up-Regulation;Ventricular;white matter;white matter damage;white matter injury

PROJECT_TITLE: Role of Choroid Plexus Autotaxin Secretion in Hemorrhage-Induced White Matter Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative The long-term goal of this project is to improve our understanding of the role of sexual and gender minority (SGM) identity-based discrimination, mistreatment, and violence in early life in producing and reinforcing broad physical and mental health disparities among SGM adult populations. To achieve this goal requires 1. development of measures that accurately assess experiences of SGM-specific adverse childhood experiences (SGM-ACEs), with specific attention towards the intersection of sexual and gender identity to account for the ways in which these experiences are similar, as well as different, and 2. continued tests of the relationships between SGM-ACEs and minority stress factors in adulthood, as well the role of interactions between early life adversity (i.e., SGM-ACEs) and minority stress exposure in adulthood contribute to ongoing physical and mental health disparities in SGM adults. As such this project aims to develop the next iteration of a promising new measure created by our team that assesses exposure to SGM-specific childhood adversity, the SGM-ACEs measure, to be more relevant and universal for SGM communities, and further expand the current Minority Stress Model by taking a life course perspective in explaining the existence of health disparities in SGM populations.

PI_NAMEs: SCHNARRS, PHILLIP W. (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;adverse childhood events;Age;Anxiety;Attention;Belief;Biological;Biological Markers;Biological Process;Bisexual;childhood adversity;cisgender;Color;community advisory board;contextual factors;County;Data;design;Development;Discrimination;Distal;early life adversity;Equation;experience;Exposure to;Factor Analysis;Frequencies;Functional disorder;Future;Gender Identity;gender minority;gender minority community;gender minority group;gender minority health;General Population;Geography;Goals;Health;health disparity;Heterosexuals;Hispanic;Homophobia;Household;human centered design;immune function;improved;Individual;Interleukin-6;Interview;Latinx;Laws;Life;Life Cycle Stages;Link;maltreatment;Measurement;Measures;Mental Depression;Mental Health;Methods;minority stress;Modeling;neglect;neurodevelopment;nonbinary;Outcome;Outcome Measure;pansexual;Participant;Pathway interactions;perceived discrimination;performance tests;physical conditioning;Policies;poor health outcome;Population;Post-Traumatic Stress Disorders;Process;Property;psychologic;psychological outcomes;Psychometrics;Qualitative Research;queer;recruit;Reporting;Research;Respondent;Risk;Role;Sampling;Sexual and Gender Minorities;sexual identity;sexual minority group;sexual role;social;social media;Social support;stressor;Surveys;Testing;Texas;theories;transgender;traumatic stress;Violence;violence exposure;virtual;web site;Work

PROJECT_TITLE: Expanding the sexual and gender minority adverse childhood experiences scale to improve measurement of SGM identity-based early life adversity

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Multiple Sclerosis;Natural Products;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Sleep Research;Spinal Cord Injury;Telehealth;Therapeutic Cannabinoid Research;Traumatic Head and Spine Injury

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The goals of this K24 application are to support Dr. Kratz’s continued development as a mentor and to grow her successful research training program for Patient-Oriented Research (POR) through an interdisciplinary translational research program focusing on complementary and integrative approaches for pain management. The awarding of the K24 Mid-Career Investigator Award would ensure that the candidate has protected time to mentor current and future mentees and securing funding to support and further expand her research program, which serves the main context for training POR clinician scientists.

PI_NAMEs: KRATZ, ANNA LOUISE (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;actigraphy;Acupressure;adaptive intervention;Adult;Analgesics;Award;Behavior;Behavioral;Behavioral Symptoms;Cannabidiol;Cannabinoids;career;chronic pain;chronic pain management;Clinical;Clinical Research;Clinical Trials;clinically significant;Collaborations;Communities;community engagement;comparative efficacy;Complementary Medicine;Complementary therapies;Coping Skills;Data;Data Set;Dedications;design;Development;Educational workshop;eHealth;Emotional;Ensure;Environment;experience;Fatigue;Feedback;Focus Groups;Frequencies;Funding;Future;Goals;Guidelines;handbook;improved;Individual;Integrative Medicine;Integrative Therapy;K-Series Research Career Programs;Leadership;learning algorithm;Licensing;Measures;meetings;Mentors;Mentorship;Methodology;Michigan;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;mind/body;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;Neurologic;next generation;Notification;Outcome;Pain;Pain interference;Pain management;pain self-management;Patient Education;patient oriented research;Persons;Phase;Phenotype;Physical activity;Physical Medicine;Physical Rehabilitation;pilot test;Polysomnography;Population;programs;Protocols documentation;Psychological reinforcement;Psychologist;recruit;Relaxation;Research;research faculty;Research Infrastructure;Research Personnel;Research Training;response;Role;Scientist;Secure;Self Management;Self Stimulation;self-management program;Site;skill acquisition;skills;Sleep;social;Spinal cord injury;spinal cord injury pain;symptom management;symptom self management;Symptoms;Testing;Tetrahydrocannabinol;Time;tool;Training Programs;translational research program;treatment as usual;treatment duration;trial planning;Universities;Update;usability;Waiting Lists;Work

PROJECT_TITLE: Patient Oriented Research and Mentoring in Multidisciplinary Chronic Pain Treatments

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Title: A novel uterine leiomyosarcoma mouse model for therapeutic development PROJECT NARRATIVE: Uterine leiomyosarcoma is a rare disease but with high-risk of recurrence and metastasis leading to poor survival rate. Little is known about the initiation and development of this disease, and currently, effective treatment is by surgery. We have developed an exciting genetic mouse model with metastatic uterine leiomyosarcoma, which will not only allow us to understanding the initiation and progression of this disease but also evaluating potential therapeutic interventions.

PI_NAMEs: WONG, KWONG KWOK  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Age;Age Months;Alleles;Aromatase Inhibitors;Biology;Clinical;clinical trial readiness;Clinical Trials;Data;Development;Diagnosis;Disease;Disease Progression;Distress;DNA;Drug Combinations;drug development;drug testing;effective therapy;efficacy testing;Endocrine;Estrogen Receptors;Euthanasia;exome sequencing;Future;Gene Expression;Gene Expression Profile;Gene set enrichment analysis;Genetic;Genetic Recombination;Genotype;Goals;Heterozygote;high risk;Histology;hormone therapy;Human;human disease;Immune;Immune system;Immunoglobulin G;Immunotherapeutic agent;Immunotherapy;Individual;Investigation;Knowledge;Learning;leiomyosarcoma;Letrozole;Lymphoma;Malignant Neoplasms;Mediating;metastatic process;Methods;Modeling;Molecular;Monitor;Morphology;mouse model;Mus;mutant;Mutation;myometrium;Neoplasm Metastasis;Nodule;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Patients;Pilot Projects;pre-clinical;Preclinical Testing;preclinical trial;Preparation;Prognosis;programmed cell death ligand 1;prospective;Proteins;Proteomics;randomized, clinical trials;Rare Diseases;Recurrence;Recurrent tumor;RNA;Signal Pathway;Site;Smooth Muscle;success;Survival Rate;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Therapeutic Studies;therapeutic target;Time;Tissues;TP53 gene;Transcript;transcriptome sequencing;treatment arm;treatment strategy;tumor;Tumor Tissue;United States;Uterine Cancer;Uterine Leiomyosarcoma;Uterus;Woman


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Plants and photosynthetic microbes are the direct or indirect source of most human foods, micronutrients, and pharmaceuticals, therefore plant biotechnology has the potential to provide great value to human health. To contribute effectively to plant biotechnology, the next generation of plant scientists should develop multidisciplinary expertise across plant biology, biochemistry, metabolic engineering, synthetic biology and computational biology. The Michigan State University Plant Biotechnology for Health and Sustainability Program introduces predoctoral students to these fields and provides them with an awareness of a broad range of careers including academia, government and industry.

PI_NAMEs: DUCAT, DANIEL C;LAST, ROBERT LOUIS (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Biotechnology;Health;Plants

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Sensorineural hearing loss (SNHL) affects nearly 50% of adults over the age of 60 and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased risk for the development of dementia in older adulthood. The studies in our proposal use combined pupillometry and cognitive event-related brain potentials to characterize the effects of listening effort on comprehension and memory functioning in older adults with and without hearing loss. If successful, this project will lead to the identification of objective and reliable neural markers of comprehension and memory processes impaired by SNHL, leading to better future clinical assessment and the improved design of evidence-based interventions to improve speech comprehension and memory in aging.

PI_NAMEs: PAYNE, BRENNAN  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Adopted;Adult;Affect;Age;age related;Aging;Area;Attention;Audiology;Award;Brain;career;Chronic;clear speech;Clinical;Clinical assessments;clinically relevant;Cognitive;cognitive neuroscience;Comprehension;cost;Data;Dementia;design;Development;Electrophysiology (science);Event;evidence base;Evidence based intervention;experience;experimental study;Extramural Activities;Foundations;Funding;Future;Goals;Health;hearing impairment;Impairment;improved;innovation;insight;Intervention;Knowledge;Language;language processing;Literature;Measures;Memory;memory process;Methods;Mydriasis;National Institute on Deafness and Other Communication Disorders;neural;Neurocognitive;neuromechanism;Noise;novel;older adult;Performance;Phonetics;Physiological;Prevalence;Process;Psycholinguistics;Public Health;Quality of life;Research;Research Priority;Resources;response;Retrieval;Risk;Semantics;Sensorineural Hearing Loss;Social isolation;specific language impairment;Speech;speech in noise;Speech Perception;speech processing;syntax;Testing;Time;Voice;Work

PROJECT_TITLE: Understanding the effects of listening effort on sentence processing and memory in sensorineural hearing loss: Evidence from simultaneous electrophysiology and pupillometry

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Traumatic brain injury (TBI) and post-TBI neurological and psychiatric problems are a major medical concern for US military veterans. Most neuroprotective therapies against TBI target gray matter and neglect the importance of white matter (WM) injury, the timely repair of which would promote WM integrity and functional restoration after TBI. The proposed study will explore salt-inducible kinase 1 (SIK1) as a novel and promising therapeutic target for TBI. We will investigate whether genetic deletion or pharmacological inhibition of SIK1 improves long- term TBI outcomes by promoting inflammation-resolving and protective microglial/macrophage responses and WM restoration. We will use state-of-the art approaches, comprehensive and long-term assessment of neurological and psychiatric functions, and both male and female subjects to gain novel mechanistic insights into the role of SIK1 in microglial/macrophage responses, brain inflammation, and WM repair after TBI. This information will be valuable for future development of new therapy against TBI for military men and women.

PI_NAMEs: CHEN, JUN  (contact)

PROJECT_TERMS: Acute;Adult;Anti-Inflammatory Agents;Apical;Arbitration;Attenuated;Axon;axon injury;axon regeneration;axonal degeneration;behavior test;Biological;Brain;brain cell;Brain Injuries;brain remodeling;C57BL/6 Mouse;Cells;Chronic;Clinical;clinical translation;Cognitive;controlled cortical impact;CREB1 gene;cytokine;Decision Trees;Demyelinations;Development;disability;effective therapy;efficacy testing;Electrophysiology (science);Emotional;Encephalitis;Equilibrium;Evaluation;Exhibits;Family;Fostering;Functional disorder;functional restoration;Funding;Future;Gene Expression;Genetic;Genetic Transcription;gray matter;Hippocampus;Histologic;Histone Deacetylase;Human;Immune;immune function;Immune response;Immunosuppression;improved;in vivo evaluation;Infiltration;Inflammation;Inflammatory;Inflammatory Response;injury and repair;insight;intraperitoneal;kinase inhibitor;Knock-out;Knockout Mice;long term recovery;Long-Term Potentiation;Macrophage;male;Measurement;Mediator;Medical;Microglia;military men;military veteran;military women;Molecular;Mus;Myelin;Myelin Sheath;Nature;neglect;Nerve Fibers;Nervous System Trauma;neuroinflammation;Neurologic;Neurologic Deficit;Neurological disability;Neurological outcome;Neurons;neuroprotection;neurotoxic;novel;novel therapeutics;Outcome;Phagocytosis;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Pilot Projects;pre-clinical;primary outcome;Production;Quality of life;Recovery of Function;Regulation;Rehabilitation therapy;remyelination;repaired;response;Rest;restoration;Role;salt-inducible kinase;Sensorimotor functions;Severities;sex;Signal Transduction;Slice;spatial memory;Tamoxifen;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Titrations;Transcription Coactivator;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;Traumatic Brain Injury recovery;Veterans;white matter;white matter injury;women subjects;Work

PROJECT_TITLE: Novel molecular strategies to promote functional recovery after traumatic brain injury


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative DYT1 dystonia is an incurable brain disease characterized by involuntary twisting movements for which there are no reliably effective treatments. This proposal employs unique genetic strategies to target a specific class of neurons (striatal cholinergic interneurons) that appear essential to the abnormal movements. These advanced genetic studies will establish the role of cholinergic interneurons in dystonia and test a novel approach to prevent or suppress the disease symptoms.

PI_NAMEs: DAUER, WILLIAM T. (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Ablation;Address;Adolescent;Autopsy;Autoreceptors;Behavioral;Biological Models;Brain;Brain Diseases;cell type;Cells;Chemicals;cholinergic;cholinergic neuron;conditional knockout;Corpus striatum structure;Data;Defect;design;designer receptors exclusively activated by designer drugs;Disease;disease model;Drug usage;Dyskinetic syndrome;Dystonia;effective therapy;Electrophysiology (science);Elements;Functional disorder;Generations;Genetic;genetic approach;genetic manipulation;Genetic study;Glutamic Acid;Goals;Human;Interneuron function;Interneurons;L-DOPA induced dyskinesia;Literature;loss of function mutation;Machine Learning;Modeling;Morphology;Motor;motor behavior;motor disorder;Movement;multidisciplinary;Mus;Muscarinics;Nerve Degeneration;Nervous System Disorder;neurodevelopment;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;novel;novel strategies;optogenetics;Output;Parkinson Disease;Pathogenesis;Patients;Pharmaceutical Preparations;predictive modeling;prevent;Publishing;Role;Signal Transduction;Slice;Symptoms;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;tomography;tool;TorsinA;translational study

PROJECT_TITLE: Cell Type Specific Genetic Manipulation to Dissect Cholinergic Interneuron Function and Plasticity in a Symptomatic Model of DYT1 Dystonia

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Peripheral artery disease (PAD), an atherosclerotic disease of the leg arteries, puts patients at high risk for myocardial infarction, stroke, and ischemic limb events. Recent trials show that an antithrombotic agent helps reduce such events in PAD, but pre-clinical data suggest this drug may be beneficial through additional pathways. We propose to investigate thrombosis and the pleiotropic effects of antithrombotic therapy in PAD.

PI_NAMEs: ADAY, AARON W. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Academic Medical Centers;Acute;Adhesions;Amputation;antagonist;Antithrombin III;Arterial Fatty Streak;Arteries;Aspirin;Atherosclerosis;Biological;Blood Coagulation Factor;Blood Platelets;Blood Vessels;cardiovascular risk factor;Cardiovascular system;career;Cell surface;Cessation of life;Chronic;Clinical;Clinical Research;clinical trial implementation;Clinical Trials;Coagulation Process;Coronary Arteriosclerosis;Data;design;Development;Dose;Double-Blind Method;Endothelium;Environment;Epidemiologic Methods;Epidemiology;Event;experience;Factor V;Factor Xa;Fibrinolytic Agents;Future;Genetic;genetic epidemiology;genome-wide analysis;Goals;Hemorrhage;High Prevalence;high risk;Human;improved;In Vitro;Individual;Inflammation;inhibitor;instructor;Intervention;Intervention Studies;Investigation;K-Series Research Career Programs;Knowledge;Lead;Leg;Life;limb ischemia;Limb structure;Link;Lower Extremity;Mediating;Mediator;Medicine;Mendelian randomization;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Morbidity - disease rate;mortality;Myocardial Infarction;new therapeutic target;novel;Outcome;PAR-1 Receptor;Pathway interactions;patient oriented;patient population;Patients;Peripheral arterial disease;personalized medicine;Persons;Pharmaceutical Preparations;Physiological;Placebo Control;Platelet Activation;platelet function;Play;pleiotropism;Positioning Attribute;pre-clinical;Randomized;randomized trial;Research;Research Personnel;Risk;Risk Reduction;Role;Signal Transduction;skills;Stenosis;Stroke;stroke risk;Testing;Therapeutic Studies;Thrombin;thrombolysis;Thrombophilia;Thrombosis;thrombotic;Thrombus;tool;Translational Research;translational research program;Variant;Vascular Endothelium;Vitamin K;Warfarin

PROJECT_TITLE: The Impact of Thrombosis and Antithrombotic Therapy on Peripheral Artery Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Antibiotic-resistant bacteria, such as vancomycin-resistant enterococci (VRE) and methicillin- resistant Staphylococcus aureus (MRSA), are major causes of hospital-acquired infections and contribute to an escalating healthcare crisis. The research proposed here promises to reveal new insights into the biological processes driving antibiotic resistance that will facilitate the development of new treatments for infections caused by drug-resistant pathogens. In particular, this work promises to define new targets for innovative therapeutics with potentially unique modes of action.

PI_NAMEs: KRISTICH, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Automobile Driving;Bacterial Antibiotic Resistance;bactericide;beta-Lactam Resistance;beta-Lactams;Binding Proteins;Biochemical;Biological Process;cell envelope;Cell Wall;Cephalosporin Resistance;Cephalosporins;Classification;Clinical;clinically relevant;clinically significant;Complex;crosslink;Cytoplasmic Protein;Data;design;Development;Disabling;drug resistant pathogen;emerging antibiotic resistance;Enterococcus;Enterococcus faecalis;Enterococcus faecium;Enzymes;Exhibits;experience;Foundations;Future;Genetic;Gram-Positive Bacteria;Growth;Healthcare;Hospitals;Hydrolase;Impairment;Infection;innovation;insight;Intervention;Knowledge;Link;Mediating;Membrane;methicillin resistant Staphylococcus aureus;Modeling;Multi-Drug Resistance;mutant;N-Acetylmuramoyl-L-alanine Amidase;Nosocomial Infections;novel;novel therapeutics;pathogen;Penicillin-Binding Proteins;Peptidoglycan;Phosphorylation;Phosphotransferases;programs;Proteins;Regulation;Reporting;Research;Resistance;response;Role;Safety;Signal Pathway;Signal Transduction;Stress;System;Testing;Therapeutic;United States;Vancomycin resistant enterococcus;Work

PROJECT_TITLE: Role and regulation of peptidoglycan synthases in enterococcal antimicrobial resistance

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE The kidneys play an essential role in adjusting fluids and electrolytes and controlling blood pressure as we go through our daily lives and eat foods that might have huge amounts or very little salt ions like sodium and potassium. Our work will shed new light on how these systems work, and suggest avenues for treatment of high blood pressure, edema and electrolyte depletion.

PI_NAMEs: PEARCE, DAVID  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acute;Adrenal Glands;Adrenalectomy;Adult;Aldosterone;Animals;apical membrane;Biochemical;Biological Assay;Blood;blood pressure control;blood pressure regulation;Cells;cohort;Complex;Cre lox recombination system;Cryoelectron Microscopy;Cultured Cells;Cytoplasm;Data;Diet;Dietary Potassium;Distal;Eating;Edema;Electrolytes;Elements;epithelial Na+ channel;Epithelium;Equilibrium;Event;Excretory function;experimental study;extracellular;Food;Gene Deletion;Gene Expression Profile;Genetic Transcription;Harvest;Homeostasis;Hypertension;Immunofluorescence Immunologic;In Vitro;in vivo;Investigation;Ion Channel;Ions;KCNJ1 gene;Kidney;Knock-out;Knockout Mice;large-conductance calcium-activated potassium channels;liquid chromatography mass spectrometry;Liquid substance;LoxP-flanked allele;Measures;Mediator;Messenger RNA;Mind;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Nephrons;novel;Oral;Osmosis;patch clamp;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Plasma;Play;Potassium;Pump;Regulation;Regulator Genes;Renal tubule structure;response;RNA;Role;scaffold;Signal Pathway;Signal Transduction;Sodium;Sodium Chloride;Specificity;steroid hormone;System;Time;Tissues;transcriptome sequencing;urinary;Wild Type Mouse;Work

PROJECT_TITLE: SGK Regulation of Epithelial Sodium Transport

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_NAME: BARNARD COLLEGE

ORG_STATE: NY

PHR: Project Narrative A distorted sense of time and diminished capacity to anticipate the future are associated with a number of psychiatric disorders including substance abuse disorder, schizophrenia and depression. Distortions in timing and anticipation are both a symptom of the disorders as well as a source of additional problems. The purpose of this grant is to understand the basic brain mechanisms that underlie these capacities in order to discover new treatments.

PI_NAMEs: BALSAM, PETER D. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adaptive Behaviors;Animal Model;Association Learning;Attention deficit hyperactivity disorder;Behavior;Behavioral;Biological;Brain;Brain imaging;Cognitive;Conditioned Stimulus;Corpus striatum structure;designer receptors exclusively activated by designer drugs;Disease;Dopamine;drug of abuse;Event;Expectancy;experience;experimental study;Extinction;Foundations;Future;Grant;Hour;Human;information framework;information processing;Information Theory;interest;Knowledge;Learning;Maps;Measures;member;Memory;Mental Depression;Mental disorders;Modeling;motor behavior;novel therapeutic intervention;Performance;Process;psychologic;Research;response;reward expectancy;Rewards;Schizophrenia;sensor;Signal Transduction;Source;Speed;Stimulus;Substance abuse problem;Symptoms;Testing;Time;time interval;Time Perception;time use;Uncertainty;Work

PROJECT_TITLE: Timing & Associative Learning

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Kidney Disease

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Maintaining blood pressure within normal limits requires regulation of the amount of Na in the body and the volume of extracellular fluids. This is accomplished in part through the actions of aldosterone - a steroid hormone produced by the adrenal gland. Understanding how this hormone acts on renal epithelial cells to control the amounts of Na retained vs. the amount excreted in the urine will help to guide management of patients with hypertension and diseases of the kidney and liver that alter the levels of salt and water in the body.

PI_NAMEs: PALMER, LAWRENCE G (contact)

PROJECT_TERMS: absorption;Adrenal Glands;Affect;Agonist;Aldosterone;Antibodies;Apical;apical membrane;Binding;Biological Assay;Biotinylation;Blood Pressure;C-terminal;Cell membrane;Cell Physiology;Cells;Cytoplasm;Data;dietary;disease model;Distal;Early Endosome;Electrophysiology (science);Endoplasmic Reticulum;Enzymes;Epithelial Cells;epithelial Na+ channel;Event;Excretory function;exosome;Extracellular Fluid;Glucocorticoids;Hormones;Human;Hypertension;immunocytochemistry;In Situ;Intake;Kidney;Kidney Diseases;Liddle syndrome;Liver diseases;Location;Measurement;Measures;Mediating;Modeling;Modification;Mouse Strains;Mus;Mutation;Nephrons;Organism;Patients;Peptide Hydrolases;Phosphorylation;Phosphotransferases;Physiological;predictive modeling;Predisposition;Process;Protein Subunits;Proteins;Proteolytic Processing;Purinoceptor;Rattus;Regulation;renal epithelium;Renal tubule structure;residence;response;Serum;Signal Transduction;Sodium Chloride;Standard Model;steroid hormone;Steroids;Surface;Techniques;Testing;trafficking;Ubiquitin;ubiquitin ligase;Ubiquitination;uptake;urinary;Urine;Water;Western Blotting;Work

PROJECT_TITLE: Regulation of ENaC Trafficking and Activity in the Kidney


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Upon successful completion of these developmental and translational aims, we will have overcome the barriers currently limiting the clinical translation of 7 Tesla MRI body imaging. The outcomes of this project will be a critical component to expanding the approved indications for clinical 7T MRI beyond the head and knee. Once in the hands of clinicians, establishing the impact of 7T on patient outcomes in prostate cancer and other pathologies and targets in the torso will be possible.

PI_NAMEs: METZGER, GREGORY JOHN (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;anatomic imaging;Anatomy;Architecture;arterial spin labeling;Beds;Biomedical Research;Biopsy;Cancer Detection;cancer imaging;Clinical;clinical imaging;clinical translation;Compensation;Databases;Deposition;design;Detection;Development;Diagnosis;Diagnostic;Electromagnetic Fields;Electromagnetics;Electronics;Environment;expectation;FDA approved;Goals;Head;Heating;Human;Human body;Image;Imaging Device;improved;improved outcome;Individual;innovation;invention;Joints;Knee;Lesion;Libraries;Location;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Methods;Modality;Modeling;Motion;Noise;Outcome;Pathology;Patient Care;Patient imaging;patient population;Patient-Focused Outcomes;Patients;Performance;Physiologic pulse;Physiological;Population Database;Prostate;Prostatectomy;Protocols documentation;radio frequency;Reader;Reproducibility;Research;Resolution;Safety;Scanning;Signal Transduction;System;targeted imaging;Techniques;Technology;Testing;Time;tool;transmission process;virtual

PROJECT_TITLE: Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Hematology;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project narrative Cardiovascular complications, such as heart failure and heart attack are some of the most devastating long- term problems faced by hematopoietic (stem) cell transplantation survivors, and are a common cause of premature death for this vulnerable population. To better understand these complications, we plan to measure stem cell transplantation survivors' cardiovascular health over time, using tests of their heart, lungs, muscles, and other organs. We will use this information to one day prevent cardiovascular complications in hundreds of thousands of stem cell transplant survivors.

PI_NAMEs: ARMENIAN, SARO  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;Biological;Blood Vessels;Body System;Cancer Survivorship;Cardiac;Cardiology;Cardiomyopathies;Cardiopulmonary;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cell Transplantation;Cessation of life;Chronic;Clinical;clinically relevant;conditioning;Consensus;Data;Development;diagnostic strategy;early onset;evidence base;Evidence based intervention;Exercise Physiology;Exercise Test;Functional disorder;Future;General Population;Goals;graft vs host disease;Health;health related quality of life;Heart;Heart failure;Hematology;Hematopoietic;Hematopoietic Stem Cell Transplantation;high risk;Image;Impairment;improved;improved outcome;Intervention;Knowledge;Late Effects;Longitudinal Studies;longitudinal, prospective study;Lung;Measurable;Measures;Metabolic;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Musculoskeletal;Musculoskeletal System;Myocardial Infarction;novel diagnostics;optimal treatments;Organ;organ injury;Oxygen;Oxygen Consumption;Patient Self-Report;Patients;Physical Function;Physiological;Population;premature;prevent;Prevention strategy;Pulmonology;Research;Research Design;Research Priority;response;Risk Assessment;Risk Factors;screening;sex;SF-36;standard measure;stem;Stem cell transplant;Survivors;symposium;System;Testing;therapy design;therapy development;Time;transplant centers;Transplant Recipients;transplant survivor;Treatment Efficacy;Treatment-Related Cancer;United States National Institutes of Health;Vascular System;virtual;Vulnerable Populations

PROJECT_TITLE: Cardiovascular reserve capacity in survivors of hematopoietic cell transplantation

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_DEPT: NEUROSCIENCES

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE  The goal of the proposed research is to investigate a novel molecular mechanism regulating microtubule-based intracellular transport in axonal morphogenesis and function. Following our recent studies of two members of a family of microtubule-associated proteins in neurons, we will use molecular, genetic, and cell biological approaches to investigate their regulation of intracellular transport and determine their roles in branch development and nociception. Results from the proposed study will provide a better understanding of transport regulation that is critical to development, function, and pathogenesis of the nervous system.

PI_NAMEs: MA, LE  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adult;Affect;Afferent Neurons;Axon;Behavioral Assay;Binding;Biological;Biological Assay;Brain;Cell Culture Techniques;Cell-Free System;Cells;Complex;CRISPR/Cas technology;Data;Defect;Development;Disease;Embryonic Development;Family;Genes;Genetic;Goals;Growth;Growth Cones;Health;Homologous Gene;Human;in vivo;insight;Intracellular Transport;Kinesin;Knockout Mice;Knowledge;Label;Link;Mammals;Mediating;Medical;member;Microtubule Proteins;Microtubule-Associated Proteins;Microtubules;Mission;Molecular;Morphogenesis;Morphology;Motor;Mus;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;Neuroglia;neuron development;Neurons;Nociception;novel;Organelles;Pain;Pathogenesis;Pathologic;Phenotype;Play;Polymers;postnatal;Process;Property;Protein Family;protein function;protein structure;Proteins;recruit;Regulation;Research;response;Rodent;Role;Spinal Ganglia;Stains;Stimulus;Structure;Tactile;Testing;United States National Institutes of Health

PROJECT_TITLE: Investigating the Role and Regulation of the MAP7 Family Proteins in Axonal Morphogenesis and Function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Chemotherapy is often ineffective when treating primary brain tumors because the interface between the bloodstream and the brain, which is called the blood-brain barrier, is not permeable to drugs in the bloodstream. Further, even those drugs that are delivered across the blood-brain barrier do not penetrate tissue effectively. In this proposal, we are testing whether the combination of an MR image-guided drug delivery approach that uses focused ultrasound to temporarily open the blood-brain barrier and a controlled- release nanoparticle formulation that penetrates brain tumor tissue can be used to effectively primary brain tumors.

PI_NAMEs: HANES, JUSTIN S.;PRICE, RICHARD J. (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Absorbable Implants;Accounting;Acids;Acoustics;Address;astrogliosis;Blood;Blood - brain barrier anatomy;Blood Circulation;Brain;Brain Neoplasms;brain tissue;Bypass;cancer cell;Cessation of life;chemotherapy;Cisplatin;Clinic;Clinical;clinical translation;Clinical Trials;contrast enhanced;controlled release;Convection;Couples;Cytoprotection;design;Development;Diagnosis;Diffusion;Dose;Drug Delivery Systems;Drug Formulations;Drug Kinetics;Engineering;Environment;Excision;experience;Exposure to;Feedback;Focused Ultrasound;Formulation;Foundations;Generations;Glioblastoma;Glioma;Gliosis;Growth;Histology;Human;image guided;image-guided drug delivery;Immunocompetent;Immunohistochemistry;Implant;improved;in vivo;Infiltration;Infrastructure;innovation;interstitial;Investigational Therapies;Lead;Libraries;Life Expectancy;Magnetic Resonance Imaging;Malignant - descriptor;Maximum Tolerated Dose;Measures;Mediating;Microbubbles;Modeling;Modification;Mus;nanoparticle;nanoparticle delivery;Nature;next generation;novel;Operative Surgical Procedures;Paper;Patient Recruitments;Patients;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Physiologic pulse;Physiological;Polyethylene Glycols;Positioning Attribute;preconditioning;pressure;Primary Brain Neoplasms;Property;Protocols documentation;Publishing;quantum;Radiation;Radiation therapy;Rattus;Reproducibility;Safety;Scheme;screening;Site;stability testing;stem cells;success;System;targeted delivery;temozolomide;Testing;Therapeutic;Therapeutic Agents;tissue preparation;Tissues;Translating;Translations;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;Tumor Tissue;ultrasound;Vision

PROJECT_TITLE: Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomas

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]