NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Human Genome;Nutrition;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE Women with Turner syndrome (TS) have a much higher risk of developing diabetes compared to the general population; however, the reasons for this are unknown. Because women with TS have alterations in their X chromosomes, much of the proposed work will focus on the role of the X chromosome in diabetes development. Knowledge gained from this project will help us better understand the cause(s) of diabetes in TS; because the role of the X chromosome in diabetes is understudied in the general population, this knowledge may be useful for our overall understanding of diabetes.

PI_NAMEs: PINNARO, CATHERINA  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Abnormal Karyotype;Affect;Age;Area;Automobile Driving;Beta Cell;blood glucose regulation;Body mass index;candidate identification;career;Cell Physiology;Chromosome abnormality;Collaborations;Complex;Continuous Glucose Monitor;Data;Data Analyses;Defect;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Management;Drug Targeting;Enrollment;Environment;Epigenetic Process;Estrogen deficiency;Faculty;Female;Feminization;Fostering;Functional disorder;Functional impairment;Gene Dosage;General Population;Genes;Genetic;Genetic Diseases;Genomics;Glucose;glucose monitor;Goals;Gonadal Steroid Hormones;high risk;Home environment;Hyperglycemia;impaired glucose tolerance;Impairment;imprint;indexing;Indiana;Individual;Insulin;insulin secretion;Iowa;Karyotype;Knowledge;Macronutrients Nutrition;male;Mentorship;Methylation;Minnesota;mortality;nanopore;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;OGTT;Oral;Outcome Study;Parents;Pathway interactions;patient oriented research;Phenotype;Physiological;Prevalence;Prevention;Prevention strategy;Preventive treatment;protective effect;Research;Research Design;Research Personnel;response;Risk;risk variant;Role;Sampling;screening;sex;Site;Specimen;statistics;Susceptibility Gene;Techniques;Testing;Training Programs;transcriptome sequencing;translational research program;translational study;Turner's Syndrome;Universities;Variant;Woman;Work;X Chromosome

PROJECT_TITLE: Hyperglycemia in Turner syndrome: Mechanisms and X chromosome contributions

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOBOKEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE High-resolution imaging is essential for studies of developmental biology. This research program will establish a multi-contrast dynamic optical imaging platform that will generate a new frontier in the live study of mammalian development and will enable a series of fundamental discoveries.

PI_NAMEs: WANG, SHANG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Behavior;Biochemical;Biological;biological development;Biological Models;Biomechanics;Biophysics;Cells;Complex;contrast imaging;Development;Developmental Biology;Developmental Process;Embryo;Exhibits;fascinate;frontier;Genes;Genetic;Genotype;Goals;Growth;high resolution imaging;Human;human disease;human model;Image;imaging approach;imaging capabilities;imaging modality;imaging platform;innovation;insight;Link;millimeter;Modeling;Molecular;Molecular Genetics;Morphogenesis;mouse model;Mus;Mutagenesis;Optical Coherence Tomography;optical imaging;Organ;Phenotype;Physiology;Process;programs;Research;Resolution;Role;Series;Speed;System;Time;Tissues;tool;virtual

PROJECT_TITLE: Multi-contrast dynamic optical imaging to advance live developmental biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cryptosporidium is a common and life-threatening pathogen in children across the globe. There is no vaccine and drug development is notoriously difficult for this intracellular parasite, thus treatments are extremely limited. Effective therapies for children and immunocompromised patients is an urgent need with the potential to save future lives. We have identified PKC, a human protein kinase, as a key factor in disease susceptibility in infants. This study will explore if PKC is necessary for parasites to invade human cells and if it can be blocked with drugs as a new potential treatment. This approach overturns the paradigm of parasite-targeted drugs and has the potential to be broadly effective, with less potential for resistance. This proposal has the potential to significantly improve human health by developing a host-targeted therapy for cryptosporidiosis.

PI_NAMEs: MARIE, CHELSEA S. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: adaptive immune response;Address;Age;Age of Onset;antagonist;Area;Bangladesh;Bioinformatics;Biology;Birth;causal variant;cell killing;Cells;Cellular biology;Child;Chromosomes;citrate carrier;Clinical;clinically relevant;cohort;Collaborations;collaborative environment;Color;Communicable Diseases;Country;Cryptosporidiosis;Cryptosporidium;Data;Development;Diarrhea;Disease;Disease susceptibility;Dominant-Negative Mutation;drug development;Drug Targeting;effective therapy;emerging antimicrobial resistance;Entamoeba;Environment;Epithelial Cells;experience;FDA approved;field study;Future;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Screening;genetic variant;Genome Scan;genome wide association study;genome-wide;Genotype;global health;Health;Heterozygote;Human;Human Genetics;Immune;Immunocompromised Host;improved;In Vitro;in vivo;in vivo Model;Infant;Infection;inhibitor;Innate Immune Response;innovation;Integration Host Factors;International;intestinal epithelium;Intestines;Introns;Invaded;Investigational New Drug Application;Knowledge;Life;Linkage Disequilibrium;low and middle-income countries;Mediator;microorganism;Molecular Biology;mouse model;multidisciplinary;Mus;novel;Outcome;parasite invasion;Parasites;Parasitic infection;pathogen;Pathogenesis;pediatric patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Positioning Attribute;Predisposition;prevent;PRKCA gene;programs;Protein Analysis;Protein Isoforms;Protein Kinase;Protein Kinase C;Protein Kinase C Inhibitor;Publications;Research Personnel;Resistance;Resources;Risk;Role;Severities;Single Nucleotide Polymorphism;skills;Sporozoites;Susceptibility Gene;targeted sequencing;targeted treatment;Testing;therapeutic target;Universities;Untranslated RNA;vaccine development;Vaccines;Validation;Variant;Virginia;Work

PROJECT_TITLE: Role of Host Protein Kinase C in Cryptosporidiosis

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This project aims to define the mechanisms that control the abundance of a class of essential non-coding RNAs that fine-tune the ribosome for efficient and accurate production of all cellular proteins. Dysregulation of these non-coding RNAs and thus, functional ribosomes, is associated with defects in gene expression that result in human disease. Determining the molecular mechanisms of these essential processes in gene expression is relevant for public health to provide potential novel targets for therapeutic intervention.

PI_NAMEs: GHALEI, HOMA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Biochemical;Biogenesis;Biological Assay;Black Box;cancer type;cell growth;Cells;Complex;Data;Defect;Deposition;Disease;Eukaryota;Event;Gene Expression;Genetic;Goals;human disease;insight;Laboratories;Lead;Maps;Mediating;Methylation;Modification;Molecular;Mutation;Nerve Degeneration;new therapeutic target;next generation sequencing;novel;Nucleotides;Pathway interactions;Pattern;Perception;Play;Post-Transcriptional Regulation;posttranscriptional;Process;Production;Protein Biosynthesis;protein complex;Proteins;Proteomics;Public Health;Reagent;Regulation;Ribonucleoproteins;Ribosomal RNA;Ribosomes;RNA;Role;Site;Small Nucleolar RNA;structural biology;Textbooks;Therapeutic Intervention;tool;Translational Regulation;Translations;Untranslated RNA;Yeasts

PROJECT_TITLE: Biogenesis of macromolecular machines for post-transcriptional regulation of translation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: FAYETTEVILLE

ORG_NAME: SFC FLUIDICS, LLC

ORG_STATE: AR

PHR: Project Narrative:  The proposed Gemini-DHAP is a dual-hormone artificial pancreas that will improve glycemic control as compared to an insulin-only artificial pancreas by providing the ability to correct a hypoglycemic condition. The Gemini-DHAP will have enhanced safety features and the necessary low dose accuracy and precision to meet the needs for insulin and glucagon delivery for people with Type 1 diabetes, especially adolescents, small adults, and individuals that are hypoglycemia unaware.

PI_NAMEs: PAYNE, FORREST  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adolescent;Adult;Advanced Development;Algorithms;Amendment;Animal Model;Artificial Pancreas;biomaterial compatibility;Bluetooth;Catheters;Chemicals;Clinical Trials;Collaborations;commercialization;Computer software;Continuous Glucose Monitor;cost;COVID-19 risk;design;Detection;Development;Devices;Diabetes Mellitus;Dose;Drug Stability;efficacy testing;Endocrinology;Evaluation;Failure;Freezing;Funding;Future;Glucagon;glycemic control;Government;Health Sciences;Hormones;Hypoglycemia;hypoglycemia unawareness;improved;in vivo;in vivo evaluation;Individual;Infection;Injections;Insulin;Insulin-Dependent Diabetes Mellitus;manufacturability;manufacture;Mechanics;Medical;meetings;Metabolic Diseases;Methods;microfluidic technology;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;Notification;Oregon;Pancreatic Hormones;Patients;Persons;Phase;phase 2 testing;Phase I Clinical Trials;Positioning Attribute;preclinical study;Preparation;prevent;prototype;Pump;Recommendation;Regulatory Pathway;response;Safety;sensor;simulation;Site;stability testing;Sterilization;subcutaneous;Syringes;System;Testing;United States Food and Drug Administration;Universities;usability;web based software;wireless;Work

PROJECT_TITLE: Advanced Development of Gemini-DHAP

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: PROJECT NARRATIVE The PRNCORP represents a coordinated effort of several institutions, medical practices, investigators and research personnel to form a single community-based research program that conducts NCI sponsored clinical research involving a large hispanic population. The program will focus on socioeconomically-disadvantaged individuals and help identity challenges and barriers that impact cancer care and outcomes.

PI_NAMEs: BAEZ-VALLECILLO, LUIS ;CRUZ, ALEXIS ;ECHEVARRÍA, MARÍA ELENA;ORTIZ, KAREN J;SANTOS-REYES, LUIS JAVIER (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Adopted;Adult;Aftercare;American Society of Clinical Oncology;anti-cancer research;base;bench to bedside;biobank;cancer care;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;care delivery;care outcomes;care providers;Childhood;Clinical;clinical care;Clinical Data;clinical imaging;Clinical Research;Clinical Treatment;Clinical Trials;Communities;community based research;Community Clinical Oncology Program;community setting;Comprehensive Cancer Center;Consent;Databases;design;Development;Digital Mammography;direct patient care;Disparity;early onset;economic disparity;Economically Deprived Population;Effectiveness;Elderly;Enrollment;Environment;Equity;Evidence based practice;experience;Faculty;Funding;Future Generations;Gastroenterology;Goals;Guidelines;Gynecologic Oncology;Gynecology;health care delivery;health care service organization;Health Insurance;Health Personnel;Health Services Accessibility;Hematology;Hispanic;Hispanic Populations;Human Resources;improved;Institution;Internal Medicine;Island;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Medical Oncology;medical schools;member;Mentors;Minority;minority communities;Modeling;multidisciplinary;National Clinical Trials Network;Oncology;Operative Surgical Procedures;organizational structure;Outcome;Palliative Care;Participant;Pathology;Patient Care;patient navigator;Patients;Pattern;Pediatric Oncologist;pediatric patients;Physicians;Population;prevent;Prevention trial;Process;programs;Provider;Puerto Rican;Puerto Rico;Quality of life;Radiation;Radiation therapy;radiological imaging;Radiology Specialty;recruit;Research;Research Methodology;Research Personnel;Research Priority;Role;screening;Screening for cancer;Series;service utilization;Services;social disparities;socioeconomic disadvantage;Source;Specialist;Structure;Surgeon;symposium;System;Tissue Donations;Tissues;tomosynthesis;Training;Translational Research;translational scientist;treatment program;tumor;underserved community;underserved minority;United States National Institutes of Health;Universities;Update;Vertebral column;West Indies

PROJECT_TITLE: Puerto Rico Minority Underserved NCI Community Oncology Research Program (Puerto Rico MUNCORP)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Axon guidance is the process by which neurons find their targets in order to build the neural circuits that allow animals to respond to information they sense in their environment. Axon guidance involves a specialized structure at the end of the neuron called the growth cone, which probes the complex three-dimensional environment of the embryo and makes directional decisions in response to the cues it detects. The goal of this proposal is to discover how one particular molecular signaling pathway called the Planar Cell Polarity pathway is used by the growth cones of neurons in the spinal cord to find their appropriate targets in the brain.

PI_NAMEs: MOENS, CECILIA B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 3-Dimensional;Actins;Animals;Anterior;Axon;axon growth;axon guidance;Behavior;Brain;cell motility;Cell surface;Cell Transplantation;Cells;Complex;CRISPR screen;Cues;Cytoskeleton;Decision Making;Dorsal;Embryo;Environment;Epithelium;Fascicle;Floor;gene function;Genes;Genetic;Genetic Markers;Genetic study;Goals;Growth;Growth Cones;Image;In Vitro;in vivo;in vivo Model;Individual;Interneurons;Invertebrates;Ipsilateral;Learning;Left;Locomotion;Mediating;Membrane;migration;Molecular;molecular asymmetry;Motor;mutant;Nervous System;neural circuit;neurodevelopment;Neuroepithelial;neuron development;neuronal growth;Neurons;optogenetics;Outcome;Pathway interactions;planar cell polarity;Play;Posture;Process;Proteins;Reagent;receptor;Resolution;response;Role;Sensory;Signal Pathway;Signal Transduction;Specific qualifier value;Spinal;Spinal Cord;Structure;System;Testing;Time;transmission process;Visualization;Visualization software;Work;Zebrafish

PROJECT_TITLE: Planar cell polarity control of axon guidance

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE There is a substantial unmet need for adolescents and young adults (AYA) HIV implementation research training in the United States among underrepresented minority AYA. This training program will build capacity in implementation science, crowdsourcing and related participatory methods, leading to innovative strategies to scale up evidence-based HIV interventions for underrepresented minority AYA.

PI_NAMEs: IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Adoption;aged;AIDS prevention;career;citizen science;cohort;Collaborations;Communities;Creativeness;crowdsourcing;design;digital;Diverse Workforce;E-learning;Education;Epidemic;Equity;ethnic minority;evidence base;Evidence based intervention;experience;Faculty;faculty mentor;Foundations;Geography;Goals;Grant;hackathon;health disparity;HIV;Human immunodeficiency virus test;implementation research;implementation science;Individual;innovation;Institution;institutional capacity;interest;Intervention;Intervention Studies;Investments;Learning;learning community;member;Mentors;Mentorship;Methods;minority children;Minority Groups;minority investigator;multidisciplinary;National Institute of Allergy and Infectious Disease;Newly Diagnosed;next generation;Nigerian;North Carolina;Persons;Population;pre-exposure prophylaxis;Prevention Research;prevention service;preventive intervention;programs;public health relevance;Qualifying;Race;racial minority;recruit;Research;Research Personnel;Research Training;Resources;Risk;scale up;self testing;Sexually Transmitted Diseases;Site;skill acquisition;social;Social support;Subgroup;Talents;Testing;testing services;testing uptake;Texas;tool;Training;training opportunity;Training Programs;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States;Universities;uptake;virtual;Youth

PROJECT_TITLE: NIAID STAR: Stimulating Training and Access to Research Experiences for Minority and Underrepresented Populations


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Currently, the best way in which to screen men for prostate cancer (PCa) is unknown, resulting in a large burden of invasive, expensive, and unnecessary PCa diagnostic investigations and therapies. Our proposed R01 will address this problem by optimizing screening and identifying “who”, “when”, and “how often” men should be screened for PCa to prevent the high morbidity and mortality of this cancer, while also reducing the physical, mental, and economic harms of screening.

PI_NAMEs: LANGSTON, MARVIN EPOLIAN (contact);SUTCLIFFE, SIOBHAN

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Address;Adoption;Age;age related;Archives;base;black men;Black race;California;Cancer Diagnostics;Cancer Etiology;Categories;Cessation of life;checkup examination;Clinical;clinical predictors;clinically relevant;cohort;Cohort Studies;comorbidity;cost;Data;design;Detection;Diagnosis;early screening;Economics;Electronic Health Record;empowerment;Erectile dysfunction;European;evidence base;Exposure to;follow-up;Frequencies;Future;Goals;Health;Health Care Costs;high risk men;high standard;Human Glandular Kallikrein 2;improved;indexing;Integrated Health Care Systems;Investigation;Kininogenase;Length;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;member;men;Morbidity - disease rate;mortality;novel;novel strategies;older men;overtreatment;Phase;Population;preservation;prevent;Preventive care;Prostate;prostate cancer prevention;prostate cancer risk;Prostate Cancer therapy;Prostate-Specific Antigen;PSA level;PSA screening;Psyche structure;Race;racial diversity;Recommendation;Relative Risks;Research Priority;Risk;risk prediction;risk stratification;Running;Sample Size;Sampling;screening;Screening for Prostate Cancer;screening guidelines;Serum;Specimen;study population;Testing;Treatment Side Effects;Uncertainty;United States Preventative Services Task Force;validation studies;Variant;young man

PROJECT_TITLE: Tailored prostate cancer screening: addressing USPSTF priority research gaps in a racially-diverse study population


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research will develop the first neurogenetic tools in ants, and map how the chemosensory system represents social and environmental stimuli in the brain. By comparing neural activity between ants that show different behavioral responses to the same stimulus, it will reveal how perception can be modulated and lead to alternative behavioral outcomes. These insights will have implications for the development of new clinical approaches for treating disorders with abnormal sensory sensitivity to social and environmental stimuli, such as autism and schizophrenia.

PI_NAMEs: KRONAUER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Afferent Neurons;Age;Animals;Ants;Area;asexual;Attention;autism spectrum disorder;Behavior;Behavioral;Behavioral Model;behavioral outcome;behavioral plasticity;behavioral response;behavioral study;Biological;Biological Models;Biology;Brain;brain circuitry;calcium indicator;Chemicals;Clinical;Communication;Communities;Complex;Cues;Data;Development;Disease;Drosophila genus;Dyes;Electrophysiology (science);Ethology;experimental study;fascinate;Foundations;Future;Genetic;Head;Human;Image;Individual;Individual Differences;Individuality;Insecta;insight;Invertebrates;Investigation;Label;Laboratories;Lobe;Maps;Microscope;Modeling;Modernization;Mus;Nervous System;neural;neural correlate;neurogenetics;neuroimaging;Neuronal Plasticity;Neurons;Neurosciences;Odorant Receptors;Odors;olfactory bulb;olfactory sensory neurons;Perception;Phenotype;Pheromone;Population;predicting response;prevent;programs;promoter;Proteins;Protocols documentation;receptor;Research;Research Personnel;Resources;response;Role;Schizophrenia;self organization;Sensory;sensory system;single-cell RNA sequencing;SLC25A4 gene;social;Social Behavior;Societies;Specificity;Stimulus;System;Theoretical model;tool;Transgenic Organisms;two photon microscopy;two-photon;Variant;Work

PROJECT_TITLE: Representation and Modulation of Social Information in the Ant Chemosensory System


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite unprecedented clinical success in the treatment of advanced cancers, immune checkpoint inhibitors are associated with immune-related adverse events. Understanding the mechanisms of immune-related adverse events is critical to identify valid biomarkers to predict and assess these events and to establish the optimal treatment strategy targeting autoimmunity while preserving antitumor immunity, both of which are triggered by immune checkpoint inhibitors. This work seeks to determine the cellular and molecular mechanisms underlying arthritis associated with immune checkpoint inhibitor therapy by utilizing patient samples.

PI_NAMEs: KIM, SANG TAEK (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Antigens;Arthritis;autoimmune arthritis;Autoimmune Diseases;Autoimmunity;Biological Markers;Biology;biomarker driven;Biometry;Blood;Blood specimen;bone erosion;cancer genomics;cancer immunotherapy;cancer therapy;carcinogenesis;career;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Clinical;cohort;Collection;Combined Modality Therapy;Complex;CTLA4 gene;Data;Development;Disease;Disease-Modifying Second-Line Drugs;Doctor of Philosophy;Dose;Epidemiology;Event;experience;Fellowship;functional genomics;Genomics;Goals;Hospitalization;Immune;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunity;Immunobiology;Immunogenomics;Immunologics;Immunology;in vivo;Inflammation;Inflammatory Arthritis;inhibitor;inhibitor therapy;innovation;insight;Malignant Neoplasms;Mentors;Mentorship;Methods;Molecular;mouse model;Oncology;optimal treatments;Pathogenesis;Patients;peripheral blood;Physicians;Play;PPBP gene;Prednisone;preservation;Principal Investigator;programmed cell death protein 1;Psoriatic Arthritis;Regulatory T-Lymphocyte;Research;Research Personnel;Research Training;Resistance;Rheumatoid Arthritis;Rheumatology;Role;Sampling;Scientist;Specificity;Steroid Resistance;Steroids;success;Synovial Fluid;T-Lymphocyte;Technology;Th1 Cells;Therapeutic;tool;Training;Training Programs;treatment strategy;tumor;Tumor Immunity;tumor immunology;Universities;Work

PROJECT_TITLE: Characterization of Altered Immunity in Patients with Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Organ Transplantation;Prevention;Social Determinants of Health;Transplantation

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Lung transplant is an increasingly common lifesaving surgery for patients with fatal lung diseases, but its success is limited by a median post-transplant survival of merely 5.5 years which is only half the survival of other organ transplant types. Troublingly, median survival also varies up to 39% depending on geographic region of the United States, and despite the profound impact of social and environmental factors on lung function, this has not been rigorously investigated in lung transplant recipients. To address this gap, we apply a geospatial framework to measure, map, and model how the cumulative social and environmental determinants of health intersect to impact post-transplant survival, and, in doing so, create unprecedented comprehensive information translatable towards reducing geographic disparities and improving survival.

PI_NAMEs: TSUANG, WAYNE M (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acceleration;Address;Adherence;Area;asthmatic patient;Bioethics;Biological Markers;Blood Tests;Cardiac;Censuses;Clinical;Clinical Data;clinical predictive model;cohort;community-level factor;comorbidity;cost efficient;County;Cox Models;Data;data repository;Data Set;detection method;Deterioration;Diabetes Mellitus;Disparity;Dose;early screening;Ensure;Environmental Health;Environmental Risk Factor;experience;Exposure to;geographic disparity;Geographic Locations;Geography;Goals;Graft Rejection;Health;health determinants;high risk;Hospitals;Immunosuppression;improved;improved outcome;Individual;Information Sciences;Injury;innovation;Institution;Intervention;Investigation;Knowledge;Life;Location;loss of function;Lung;Lung Diseases;Lung Transplantation;Maps;Measurement;Measures;Methods;Modeling;mortality risk;multilevel analysis;novel;Operative Surgical Procedures;Organ Donor;Organ Transplantation;Outcome;Patient Care;patient stratification;Patients;Performance;Persons;Pharmaceutical Preparations;Policies;pollutant;Population;post-transplant;predictive modeling;prevent;primary outcome;pulmonary function;Resource Allocation;Risk;Risk Factors;risk stratification;Role;secondary outcome;social;social factors;social vulnerability;spatial epidemiology;success;survival disparity;survival prediction;Testing;Time;Translations;transplant centers;Transplant Recipients;transplant registry;Transplantation;transplantation medicine;United States;United States Dept. of Health and Human Services;Variant

PROJECT_TITLE: A place-based approach to geographic disparities in lung transplant

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sepsis is common and deadly in children, and clinical trials have been hampered by patient heterogeneity. Clustering together patients with shared pathophysiologic or biomarker profiles are one strategy to identify subgroups with shared underlying biology to better target interventions. The proposed studies will assess whether the results of an ongoing trial of different fluids used for resuscitation are broadly applicable to all septic children, or whether their effects are more pronounced in some subgroups, as well as investigate the mechanisms underlying the relationship between fluid choice and kidney function.

PI_NAMEs: YEHYA, NADIR  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Angiopoietin-2;Antibiotics;arm;Bicarbonates;biobank;Biological;Biological Markers;Biology;biomarker selection;Blood Platelets;Cessation of life;Child;Childhood;classification trees;Clinical Trials;Critical Illness;Critically ill children;crystalloid;Data;Dialysis procedure;Endothelial Cells;Endothelium;Enrollment;Epidemiology;Event;experience;Fluid Therapy;Functional disorder;Future;Glycocalyx;Goals;Heterogeneity;Hospitalization;Hour;Human;Immune response;improved;Infection;Inflammatory;innovation;Inpatients;Interleukin-6;Interleukin-8;Intervention;Kidney;kidney dysfunction;Knowledge;Lactated Ringer's Solution;Link;Liquid substance;Measures;Mediating;Mediation;Methods;Modeling;mortality;mortality risk;Normal saline;Outcome;patient oriented;Patients;pediatric sepsis;Phenotype;Plasma;Population;predictive modeling;prognostic;prognostic model;prognostic value;Randomized;randomized trial;regression trees;Renal function;response;Resuscitation;Risk;risk stratification;Sepsis;septic;Serum;Subgroup;Supportive care;syndecan;Syndrome;targeted treatment;Testing;TNFR-Fc fusion protein;TNFRSF1A gene;treatment effect;United States;Validation

PROJECT_TITLE: Finding Appropriate Subtypes in a Trial of Balanced versus nOrmaL Saline FlUid in Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The UC Davis Clinical and Translational Science Center (CTSC) has established workforce development and infrastructure resources that supports and promotes education and research activities to improve human health. Innovative translational and clinical research findings are disseminated to health professionals, trainees, scholars, and community partners, and function within national collaborative networks to ensure a broad-based information exchange that will lead to improved human health across all age groups. Project Narrative Page 201

PI_NAMEs: KENYON, NICHOLAS J.;LYLES, COURTNEY REES;WUN, THEODORE  (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;Achievement;Address;age group;Agriculture;Area;Biological Sciences;burden of illness;California;career;career development;catalyst;Center for Translational Science Activities;Clinical and Translational Science Awards;clinical investigation;Clinical Research;Clinical Sciences;Collaborations;college;Communities;community based participatory research;community engagement;community involvement;Community of Practice;community partners;community partnership;Competence;Complex;Data Science;data science resource;Decision Making;design;digital health;Discipline;Discipline of Nursing;Diverse Workforce;Educational Activities;Effectiveness;Engineering;Ensure;Environment;Environmental Science;Evolution;experience;Faculty;Feedback;flexibility;Fostering;Foundations;Funding;Future;Goals;Health;health care availability;health care delivery;health equity promotion;Health Professional;Health system;Health Technology;Human;improved;Informatics;Infrastructure;innovation;Institution;Integrated Delivery of Health Care;Lead;Leadership;Learning;Letters;life span;medical schools;Methods;Multiple Partners;novel;Outcome;patient oriented research;Phase;Play;Population Heterogeneity;Primary Care;Process;Productivity;Program Development;programs;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Training;Resource Sharing;Resources;Role;Rural Community;Rural Population;Science;science education;skills;Special Population;Structure;success;Techniques;telehealth;Textiles;tool;Training;Translational Research;translational research program;translational scientist;Trust;Underserved Population;Universities;Urban Community;urban underserved;Veterinary Medicine;Veterinary Schools;Work;Workforce Development;workforce needs


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The cerebellum’s role in motor learning is dependent on the computations performed by neurons that compose its circuits. Yet the heterogeneity and functional organization of the neuron types in cerebellar cortex are not fully known, preventing elucidation of how the cerebellum implements adaptive behavior. Therefore, the goal of this study is to characterize the diversity of inhibitory molecular-layer-interneuron subtypes and determine how their neural connections allows for them to play a determinant role in error-driven motor learning, insight that is required to understand how the cerebellum operates in health and disease.

PI_NAMEs: CHRISTIE, JASON M (contact);HANTMAN, ADAM

PROJECT_TERMS: Ablation;Acute;Adaptive Behaviors;adaptive learning;Affect;Amendment;anatomical tracing;Anatomy;Architecture;Behavior;Behavioral;Brain;Calcium Signaling;Calcium Spikes;Categories;cell type;Censuses;Cerebellar Cortex;Cerebellum;Conflict (Psychology);connectome;Data;Dedications;Dendrites;Disease;Disinhibition;Effectiveness;Ensure;Exhibits;Fiber;Fire - disasters;flexibility;Genetic;Genetic Techniques;Goals;granule cell;Health;Heterogeneity;improved;insight;interdisciplinary approach;Interneurons;Knowledge;Learning;Logic;Maps;Mediating;Modeling;Molecular;Molecular Genetics;Molecular Target;Morphology;mossy fiber;Motor;motor learning;Movement;Mus;Myoepithelial cell;neocortical;neural;neural circuit;Neurons;operation;Outcome;Output;Pathway interactions;Pattern;Physiological;Play;prevent;Process;Purkinje Cells;recruit;response;Role;Specific qualifier value;stellate cell;Stimulus;Structure;Supervision;support network;Surveys;Synapses;Synaptic plasticity;Taxonomy;Testing;theories;vestibulo-ocular reflex

PROJECT_TITLE: Organization of inhibition in the cerebellar cortex


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The overarching goal of this proposed research is to help reduce COVID-19 health disparities in mass transit workers. Working in close collaboration with the Transport Workers Union, Local 100, our study will explore the impact of existing multilevel interventions on transit workers’ health and wellbeing.

PI_NAMEs: GERSHON, ROBYN R.M. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Adoption;Advocacy;age effect;anxious;authority;Behavioral;Cessation of life;Characteristics;Charge;Cities;Collaborations;Communities;community based participatory research;community engaged research;community partners;Community Workers;Commuting;COVID-19;COVID-19 health disparity;COVID-19 intervention;COVID-19 pandemic;COVID-19 vaccine;Cross-Sectional Studies;Data;design;Development;Disparity;Education and Outreach;Effectiveness;Employment;Equipment;Essential worker;ethnic minority;Ethnic Origin;Event;experience;Exposure to;Family member;Federal Government;first responder;Friends;Frontline worker;Gender;General Population;Goals;Harm Reduction;Health;Health behavior;Healthcare;High Prevalence;high risk;high risk population;Home;hospitalization rates;improved;Individual;Infection;infection rate;Interpersonal Relations;Intervention;Leadership;Local Government;Maps;Masks;Measures;member;Mental Health;metropolitan;Modeling;National Institute on Minority Health and Health Disparities;new pandemic;New York City;Occupational;Occupations;operation;Outcome;pandemic disease;pandemic preparedness;Personal Satisfaction;Phase;physical assault;Pilot Projects;Policies;professional atmosphere;promote resilience;protective behavior;Psychological reinforcement;psychosocial;Psychosocial Factor;Public Health;Quarantine;Race;racial minority;Recommendation;Reduce health disparities;Reporting;Research;Research Methodology;resilience;response;Risk;risk mitigation;Risk Reduction;Role;Safety;Sampling;SARS-CoV-2 infection history;Self Efficacy;Services;sex;Social Distance;Social support;State Government;Stigmatization;Subway;Supervision;Surveys;System;Time;Training;Transportation;Update;uptake;vaccine distribution;Vaccines;Verbally abusive behavior;Virus;Work;Workplace

PROJECT_TITLE: NYC Transit Workers and COVID-19: Impact of Multilevel Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: The proposed research will integrate two validated assays, imaging (CT and bone scintigraphy) and circulating tumor cells, to create the first measure of whether metastatic prostate cancer is responding to treatment. This will improve care by allowing non-responding patients to switch to other treatments, and facilitate the development of new therapies for the second-largest cause of cancer death in men.

PI_NAMEs: MORRIS, MICHAEL J;SCHWARTZ, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: abiraterone;Aftercare;American;androgen independent prostate cancer;Biological Assay;Biological Markers;bone;bone imaging;Bone Tissue;burden of illness;Cancer Etiology;Caring;Cessation of life;chemotherapy;Choline;Clinical;clinical care;Clinical Trials;Data;Data Set;Development;Disease;docetaxel;drug development;Event;FOLH1 gene;Future;Goals;Guidelines;Image;image processing;imaging biomarker;imaging modality;Imaging Techniques;improved;indexing;kinetic model;Lesion;liquid biopsy;Liquid substance;Lymph;lymph nodes;Malignant neoplasm of prostate;Measurement;Measures;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methods;Modality;Modeling;Molecular;Monitor;Neoplasm Circulating Cells;novel;novel imaging technique;novel therapeutics;Outcome;Patients;Performance;Phase III Clinical Trials;Positron-Emission Tomography;predicting response;predictive modeling;Prednisone;Prognosis;Prognostic Factor;prognostic model;prognostication;progression marker;Progression-Free Survivals;prospective;Qualifying;Radiation therapy;radiological imaging;Radionuclide Imaging;Radium;Recommendation;Research;Research Design;response;serial imaging;soft tissue;Soft Tissue Disorder;Standardization;Statistical Models;Techniques;temporal measurement;Testing;Time;time use;Training;treatment effect;treatment response;tumor;Tumor Burden;Validation;working group

PROJECT_TITLE: Clinical Qualification of Imaging and Fluid-Based Tumor Monitoring Biomarkers for Metastatic Castration Resistant Prostate Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The error-related negativity (ERN) is a biomarker of error processing that can predict future onset and worse outcomes of anxiety disorders in young children and is therefore a potential target to offset the development of anxiety disorders; however, a number of factors make the ERN difficult to measure, including relying on people to spontaneously click the wrong button on a small fraction of hundreds of trials. The balance N1 is a comparable biomarker that can be robustly and reliably measured in response to a single perturbation to upright standing balance and is associated in amplitude with the ERN in younger and older adult populations and may therefore provide a more robust measurement of the same underlying neural system. The proposed project will validate the balance N1 against the ERN in young children with and without anxiety disorders, and test whether an intervention to reduce the ERN transfers to a similar reduction of the balance N1, which may provide insight into prior work demonstrating that balance training can alleviate anxiety in children, and well- documented benefits of psychotherapy to balance disorders, which may ultimately facilitate the development of multidisciplinary interventions for anxiety.

PI_NAMEs: PAYNE, AIDEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adult;Age;Aging;Anxiety;Anxiety Disorders;anxious;Balance training;Behavior;Behavioral;Biological Markers;Brain;Chest;Child;Clinical;Clinical Research;Cognitive;cognitive task;comparison control;computer game;computerized;Computers;Data;detection platform;Development;Diagnosis;equilibration disorder;Equilibrium;Event-Related Potentials;expectation;Frequencies;Future;Generalized Anxiety Disorder;Goals;healthy lifestyle;Hyperactivity;Individual;Individual Differences;insight;Instruction;Intervention;intervention effect;K-Series Research Career Programs;Life;Measurement;Measures;Mentors;Methodology;Monitor;Motivation;Motor;multidisciplinary;neural;neural correlate;Neurodevelopmental Disorder;neuromechanism;novel;Obsessive-Compulsive Disorder;older adult;Outcome;Output;Participant;Pathologic;Persons;Population;Prevention;Psychopathology;Psychotherapy;Randomized;Reaction;Research Project Grants;response;Risk;Sampling;Scalp structure;Severities;Social Anxiety Disorder;Speed;System;Testing;Therapeutic Intervention;Thinness;Training;treatment of anxiety disorders;Work;young adult

PROJECT_TITLE: Investigating the error-related negativity and the balance N1 in children with anxiety disorders


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE  Cardiac sodium channel dysfunction underlies life-threating arrhythmias. We present new approaches to define the neighborhood of proteins that regulate cardiac sodium channels and how these proteins affect sodium channel function and dysfunction in normal and pathologic states.

PI_NAMEs: MARX, STEVEN O;PITT, GEOFFREY S (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Action Potentials;Affect;ANK3 gene;Anterior;aorta constriction;Arrhythmia;Arteries;ascorbate;Binding;Biotin;Brugada syndrome;Calibration;candidate validation;Cardiac;Cardiac Myocytes;Cardiomyopathies;Chronic;cohort;Complex;Congestive Heart Failure;Coupled;Crossbreeding;defined contribution;design;Development;Dilated Cardiomyopathy;Disease;Fibroblast Growth Factor;fibroblast growth factor 13;Functional disorder;Generations;Goals;Heart failure;In Situ;Individual;Infusion procedures;Inherited;innovation;insight;Intercalated disc;Investigation;Ion Channel;Isoproterenol;junctophilin;knock-down;Knock-out;Label;Lateral;Left;Life;Ligase;Ligation;Long QT Syndrome;Macromolecular Complexes;Maps;Mass Spectrum Analysis;member;Membrane;Modeling;mouse model;Multiprotein Complexes;Mus;mutant;Mutation;Neighborhoods;novel;novel strategies;overexpression;Pathologic;Peroxidases;Phosphoproteins;Physiological;pressure;Property;protective effect;Proteins;Proteomics;Records;Regulation;Risk;Role;Signal Transduction;Sodium Channel;Specificity;tool;Validation;voltage

PROJECT_TITLE: Dynamic changes of the Nav1.5 interactome and contributions to heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioids;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: The proposed study is highly relevant to public health, as data from the planned US population survey would allow more accurate estimation of negative impacts of alcohol, tobacco and drugs like marijuana, opioids and methamphetamine on people other than users themselves. The study will identify relevant risk factors of individuals, their social environments, and their neighborhoods and communities, which will be useful for planning targeted interventions and prevention programs to protect people at risk of harm. Results also will provide evidence to inform debates on effective policy strategies to reduce alcohol- and drug-related harm.

PI_NAMEs: KARRIKER-JAFFE, KATHERINE J.;KERR, WILLIAM C. (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Abate;Adult;Affect;Age;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol epidemiology;alcohol tobacco and other drug use;Alcohols;Anxiety;Area;Case Study;Characteristics;Child;Chronic;Cocaine;Communities;community planning;cost;Country;COVID-19 pandemic;COVID-19 pandemic effects;Crime;Data;Data Reporting;Dedications;design;Development;Disparity;Distress;drinking;driving under influence;Drug usage;Environment;environmental tobacco smoke;Equipment and supply inventories;ethnic minority;Ethnic Origin;experience;Extended Family;Family;Family member;follow-up;Foundations;Friends;Funding;Future;Gender;Gender Identity;gender minority;Grant;Harm Reduction;Health Policy;Health Status;Heroin;Income;Individual;innovation;Intervention;intervention program;Knowledge;Legal;Legal Status;Life Cycle Stages;Literature;Marijuana;Medical;Mental Depression;Mental Health;Methamphetamine;Monitor;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;Opioid;Opioid Analgesics;opioid epidemic;Patient Self-Report;Pattern;perpetrators;Persons;Pharmaceutical Preparations;Pharmacotherapy;physical conditioning;Policies;Policy Developments;polysubstance use;Population;population survey;Populations at Risk;Prevalence;Prevention;Prevention program;Productivity;programs;Public Health;Quality of life;Race;racial minority;Recreation;Report (document);Research;Risk Factors;Role;Series;Severities;Sex Orientation;Sexual and Gender Minorities;social;Social Controls;Social Environment;social relationships;Socioeconomic Status;Solid;Spouses;Stimulant;Stress;Subgroup;substance use;Surveys;Taxes;Tobacco;trend;Urbanicity;Woman

PROJECT_TITLE: Secondhand Harms from Alcohol & Drugs: Impacts on Families and Communities across the US

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Data Science;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Most current studies focus on pharmacological intervention (PI) for Alzheimer's disease and related dementia (AD/ADRD); however, increasing evidence from multimodal studies elucidates possible synergistic effects of PI and non-pharmacological intervention (NPI) for AD/ADRD. To respond to the PAR-20-156, the objective of this application is to develop translational informatics approaches to aggregate, standardize and discover the synergistic effects of PI and NPI candidates on AD/ADRD using multi-modal data resources (i.e., literature, EHR, clinical trials) followed by animal model validation. The successful completion of this project will deliver a comprehensive NPI knowledge graph, novel informatics approaches, ranked list of drug and NPI candidates, and validated synergistic intervention using multi-modal data sources.

PI_NAMEs: XU, HUA ;ZHANG, RUI  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Aerobic Exercise;Affect;alternative treatment;Alzheimer's Disease;Alzheimer's disease related dementia;American;Animal Model;Animals;Aromatherapy;base;Brain Diseases;clinical investigation;Clinical Trials;Clinical Trials Design;Cognitive aging;cognitive function;cognitive training;Collaborations;Communities;computerized tools;Data;data resource;Data Sources;Dementia;Development;Diet;dietary supplements;Disease;drug discovery;drug repurposing;effective therapy;Electronic Health Record;Environmental Risk Factor;Gene Targeting;Genetic Risk;Goals;improved;in silico;in vivo;Individual;Informatics;information model;innovation;Intervention;intervention effect;Knowledge;knowledge graph;Link;Literature;Methods;Mining;Modeling;mouse model;multimodal data;multimodality;Natural Language Processing;Network-based;neural network;Nonpharmacologic Therapy;novel;older adult;Ontology;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phototherapy;population based;predictive modeling;prevent;Prevention;protective factors;Reporting;Research;Signal Transduction;Site;Sleep;Standardization;synergism;tool;Translating;Validation;Visualization;Work

PROJECT_TITLE: Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRD


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Between 22-40% of lesbian, gay, bisexual, and transgender (LGBT) young adults are polytobacco users, meaning they concurrently use multiple nicotine and tobacco products, and low tobacco risk perceptions may be an influencing factor. The proposed study uses crowdsourced (Aim 1), in-laboratory (Aim 2), and Phase I randomized controlled trial (Aim 3) studies to determine effective message framing and targeting to communicate polytobacco use risk to LGBT young adult polytobacco users, and if exposure to anti-polytobacco communications delivered via text messaging reduces tobacco use in this population. Findings will provide public health officials, the National Cancer Institute, and the Food and Drug Administration critical information about optimal anti-polytobacco message framing and digital dissemination strategies that may be leveraged in national health communications.

PI_NAMEs: PATTERSON, JOANNE G (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Address;Adult;Affect;Area;Attention;Behavior;Behavioral;biobehavior;cigarette smoking;Communication;cost;crowdsourcing;cultural values;Data;digital;digital media;Disparity;dissemination strategy;Effectiveness;effectiveness testing;Electronic Nicotine Delivery Systems;Evaluation;Exposure to;Future;Galvanic Skin Response;Goals;Harm Reduction;Health;health communication;Knowledge;Laboratories;Lesbian Gay Bisexual Transgender;Life;Literature;Measurement;Measures;Methods;Multimedia;National Cancer Institute;Nicotine;Nicotine Dependence;Patient Self-Report;Persons;Phase;polytobacco;polytobacco use;Population;Populations at Risk;prevent;Psychophysiology;Public Health;Randomized, Controlled Trials;reduce tobacco use;Relative Risks;Reporting;Research Priority;Risk;Risk Behaviors;risk perception;Risk Reduction;Science;skills;Smoker;smoking cessation;Testing;Text;Text Messaging;Time;Tobacco;Tobacco Control Research;tobacco products;Tobacco use;Tobacco Use Cessation;Training;United States Food and Drug Administration;uptake;visual tracking;young adult

PROJECT_TITLE: Testing the effect of anti-tobacco message framing on polytobacco use in lesbian, gay, bisexual, and transgender young adults


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Although cholestatic liver diseases are heterogeneous, a subset of patients with cholestasis have decreased expression of β-catenin that may cause or exacerbate disease progression. In this proposal, we will use transcriptomics analysis to validate two mouse models that phenotypically resemble primary sclerosing cholangitis (PSC) and progressive familial intrahepatic cholestasis (PFIC), and determine the subset of PSC and PFIC cases they represent. We will also use these mouse models to assess the contribution of β-catenin to maintenance of cell polarity and cholangiocyte pathobiology in the context of cholestatic liver disease.

PI_NAMEs: MONGA, SATDARSHAN SINGH;NEJAK-BOWEN, KARI N (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Address;Adherens Junction;advanced disease;Animal Model;beta catenin;Bile Acid Biosynthesis Pathway;Bile Acids;bile duct;Bile fluid;Biological;Biology;Cell Maintenance;Cell Maturation;Cell Polarity;cell type;Cells;Characteristics;Childhood;cholangiocyte;Cholestasis;Chronic;Clinical;clinically relevant;Compensation;Defect;differential expression;Disease;disease model;disease phenotype;Disease Progression;disorder subtype;Disparate;epithelial to mesenchymal transition;Epithelium;Etiology;Event;Failure to Thrive;Fibrosis;Funding;Genes;Hepatocyte;Human;human data;human disease;Impairment;induced pluripotent stem cell;Injury;innovation;insight;Intercellular Junctions;Investigation;Knock-out;Knockout Mice;Life;Ligation;Liver;Liver Fibrosis;liver transplantation;LoxP-flanked allele;Medical;Mesenchymal;Modeling;mortality;mouse model;Mus;novel;osteopontin;Pathogenesis;Pathway interactions;patient subsets;Patients;Phenotype;plakoglobin;Pre-Clinical Model;prevent;primary sclerosing cholangitis;Process;Progressive intrahepatic cholestasis;Regulation;Role;Sample Size;Signal Transduction;Site;Testing;Therapeutic;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;WT1 gene;WT2 gene

PROJECT_TITLE: Role and regulation of beta-catenin in cholestatic liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative (3 sentences) Our goal is to investigate the factors that influence sex differences in Alzheimer's disease. There is clear evidence that females are more at risk to develop AD than males and that this is exacerbated by the presence of the APOE ε4 allele. We hypothesize that sex chromosome dose and ε4 alleles impact neuroinflammation and we will determine the role of sex-chromosome linked genes that interact with ε4 in this sex-specific susceptibility to disease, which may help adjust treatment.

PI_NAMEs: DISTECHE, CHRISTINE M.;JAYADEV, SUMAN ;YOUNG, JESSICA ELAINE (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;Age Factors;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Autopsy;Bioinformatics;Biological Assay;Brain;brain cell;brain tissue;Candidate Disease Gene;Cell Culture Techniques;Cell Line;Cell model;cell type;Cells;Cellular Assay;cerebral atrophy;cognitive function;cohort;Complex;Computational Biology;Data;data integration;Dementia;Development;Disease;disease phenotype;Disease Progression;dosage;Dose;effective therapy;Environmental Risk Factor;Epigenetic Process;Event;Exclusion;Female;Functional disorder;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene interaction;Gene Modified;Genes;Genetic;genetic risk factor;genetic variant;genome wide association study;genome-wide analysis;Genotype;Goals;Gonadal Steroid Hormones;Health;high risk;Hormonal;Hormones;human induced pluripotent stem cells;human tissue;Immune;immune function;Impaired cognition;In Vitro;Individual;Inflammation;Inflammatory Response;innovation;insight;knock-down;Late Onset Alzheimer Disease;Life Style;lifetime risk;Ligands;Link;Longevity;male;men;Metabolic Pathway;Methods;Microglia;Molecular;mosaic loss;Myelogenous;Nerve Degeneration;Neurobiology;Neuroimmune;neuroinflammation;Neurons;neuropathology;novel;Organoids;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Ploidies;Predisposition;Protocols documentation;receptor;Research;response;Risk;Risk Factors;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;Sex Factors;single nucleus RNA-sequencing;stem cell model;Structure;synergism;Testing;Tissues;tool;transcriptomics;two-dimensional;Variant;Woman;X Chromosome;X Inactivation

PROJECT_TITLE: Dissecting the role of sex-linked genes and APOE e4 risk in AD


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Disability Research;Hearing Loss;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Diabetes rates are higher in Deaf and hard of hearing (DHH) populations than hearing populations, most likely due to an information disparity. We aim to increase access to diabetes education content by developing and testing a website in American Sign Language. We expect that providing culturally and linguistically tailored diabetes website will significantly reduce health disparities in the DHH community.

PI_NAMEs: LITCHMAN, MICHELLE L (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Affect;American Sign Language;bilingualism;Blood Glucose;Caring;Cellular Phone;Communication;Communities;community advisory board;community engagement;community partners;Data;deaf;design;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;Disparity;Education;education resources;Educational Materials;English Language;Event;evidence base;experience;Focus Groups;Friends;gaps in access;Glucose;Goals;hard of hearing;Health;health literacy;Hearing;Improve Access;improved;indexing;Information Resources;Infrastructure;Internet;Intervention;Interview;Language;Librarians;Linguistics;Measures;Medical;Methods;Modeling;Nutrition Labeling;Outcome;performance tests;Persons;Pharmaceutical Preparations;podcast;Population;Process;prototype;Reading;Recommendation;Reduce health disparities;Research Personnel;Resources;satisfaction;social media;Structure;syntax;System;Technology;Testing;theories;trustworthiness;United States National Aeronautics and Space Administration;United States National Library of Medicine;uptake;usability;user centered design;Visual;web site;webinar;Work;Writing

PROJECT_TITLE: Improving Access to Diabetes Information for Deaf and Hard of Hearing Populations

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE There is an urgent need to reduce the persistent racial disparities in breast cancer outcomes in the U.S and the advances in precision medicine have left African Americans behind. The primary objective of this study is to build a risk assessment tool for women of African descent from genetic alterations in genes that contribute to increased breast cancer risk, and combine this tool with environmental and lifestyle risk factors of breast cancer. We also wish to find the causal risk factors for breast cancer that share across populations.

PI_NAMEs: HUO, DEZHENG  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: access disparities;Address;African;African American;African American population;African American Women;African ancestry;African Women;Age;ancestry analysis;Asian;Asian ancestry;Asian population;Assessment tool;black women;Breast Cancer Detection;Breast Cancer Genetics;Breast Cancer Model;Breast Cancer Risk Factor;cancer subtypes;Case/Control Studies;causal variant;Clinical;clinical practice;cohort;Cohort Studies;Complex;Data;Data Pooling;Data Set;Death Rate;Development;early onset;Elasticity;Epidemiology;Estrogen receptor negative;Estrogen receptor positive;Estrogen Receptors;Ethnic Population;European ancestry;Family history of;Funding;Gene Frequency;Genes;Genetic;Genetic Counseling;Genetic Diseases;genetic predictors;genetic variant;genome wide association study;genome-wide;genome-wide analysis;genomic locus;high risk;improved;Incidence;Individual;innovation;Investigation;Knowledge;Lasso;Left;Life Style;Linkage Disequilibrium;Malignant Breast Neoplasm;Mammographic screening;Maps;Methods;Modeling;multi-ethnic;Mutation;Noise;non-genetic;novel;Outcome;Penetrance;Performance;polygenic risk score;Population;precision medicine;Predisposition;Prevention;Public Domains;Quantitative Trait Loci;Race;racial disparity;Racial Equity;racial population;Reproductive History;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;RNA Splicing;Sample Size;Scoring Method;screening;Signal Transduction;Statistical Methods;statistics;Susceptibility Gene;Target Populations;Testing;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational impact;triple-negative invasive breast carcinoma;Variant;Veterans;White Women;Woman;Women's study

PROJECT_TITLE: Polygenic Risk Prediction of Breast Cancer for Women of African Descent

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose to train graduate and medical students, and junior physicians and scientists, to become successful researchers in topics related to heart, lung and vessel disease. Modern medicine and public health more and more need physicians and scientists from different research backgrounds to work in teams and across traditional boundaries. This will allow them to have more novel ideas by bringing together very different perspectives. Our program aims to train such individuals.

PI_NAMEs: DONAHUE, J KEVIN;KIEFE, CATARINA I. (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Cardiovascular system;Research;Training

PROJECT_TITLE: Transdisciplinary Training In Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: GABAergic interneurons (INs) are critical for the normal function of the brain and have been implicated in human disease. This research project is focused on VIP interneurons, which are the largest IN population in the superficial layers of the cerebral cortex, and have emerged as the main source of cortical disinhibition, a mechanism important in the regulation of perception and high order cognitive function. VIP INs have been shown to comprise a diverse population with structurally and functionally distinct subtypes and this project will use novel reagents and experimental approaches to examine the connectivity and function of distinct VIP IN subtypes.

PI_NAMEs: RUDY, BERNARDO  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Anxiety Disorders;Area;area striata;Arousal;Attention;autism spectrum disorder;awake;Axon;basal forebrain;Behavioral;Brain;Cerebral cortex;childhood epilepsy;cholinergic;Cognition;Cognitive deficits;cognitive function;Data;Disease;Disinhibition;Electrophysiology (science);Epilepsy;experimental study;Feedback;Functional disorder;Genetic;genetic approach;Glutamates;Goals;Head;hippocampal pyramidal neuron;human disease;Image;imaging modality;in vivo;innovation;Interneuron function;Interneurons;Knowledge;Learning;Light;Location;Mediating;Methods;Morphology;Motor;Mus;Neocortex;Neurons;Neuropeptides;novel;optogenetics;Output;Pattern;Perception;Pharmacogenetics;Population;Population Heterogeneity;postsynaptic;Process;Property;Psychological reinforcement;Reagent;recruit;Regulation;Research Project Grants;response;restraint;Rett Syndrome;Role;Schizophrenia;Sensory;sensory cortex;sensory integration;signal processing;Signal Transduction;Slice;Somatostatin;Source;spatiotemporal;Structure;Synaptic plasticity;Testing;Transgenic Mice;two-photon;Vasoactive Intestinal Peptide;visual control;Work

PROJECT_TITLE: Inhibitory and Disinhibitory VIP Interneuron-Mediated Circuits in Neocortex

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


PHR: PROJECT NARRATIVE We are studying the basic biology underlying the formation of fat droplets in cells. This process is critical to meet the demands in cells for metabolic energy, but when uncontrolled leads to obesity, type 2 diabetes, fatty liver disease, and other metabolic diseases of fat excess. By understanding how these processes occur and are regulated, our work will advance our understanding of these conditions and may lead to new therapies to treat them.

PI_NAMEs: FARESE, ROBERT V (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acyltransferase;Address;Adopted;Area;Atherosclerosis;Binding;Binding Proteins;Biochemical;Biochemistry;Biology;BSCL2 gene;Cell Physiology;Cells;Cellular biology;Complex;Cryoelectron Microscopy;Cytoplasm;Cytosol;Data;Emulsions;Endoplasmic Reticulum;Energy Metabolism;Ensure;Enzymes;Eukaryotic Cell;experimental study;Face;Fatty acid glycerol esters;fatty liver disease;Generations;Glycerol;Human;In Vitro;in vitro testing;insight;Investigation;Lipid Bilayers;Lipid Inclusion;Lipids;Membrane;Membrane Lipids;membrane synthesis;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;monolayer;monomer;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Organelles;particle;Phase Transition;Phospholipids;prevent;Process;protein complex;protein function;Proteins;reconstitution;Research;Set protein;simulation;Site;structural biology;Structure;Testing;tomography;tool;Triglycerides;Work

PROJECT_TITLE: Mechanisms of Lipid Droplet Formation

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Nanotechnology;Pediatric;Rare Diseases

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative  Congenital heart defects (CHDs) are a major global health burden, responsible for over 250,000 deaths annually and lasting complications for the estimated 12 million people living with CHDs. Without the ability to substantially alter the prevalence of CHDs, new medical technologies are needed to improve survival and quality of life. The goal of this proposal is to develop a stimuli-responsive material that can be integrated with existing medical devices, such as pulmonary artery bands, to permit adjustability acutely (e.g. due to physiological changes) and chronically (e.g. to accommodate growth) thereby improving patient outcomes and reducing costs.

PI_NAMEs: SKILLIN, NATHANIEL PHILLIP (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: 3D Print;Acceleration;Acute;Address;Adopted;Affect;Animals;Arteries;Biocompatible Materials;Biological Testing;biomaterial compatibility;Blood;Blood flow;Body Weight;cancer therapy;Cardiac;career;career development;Catheters;Cell Culture Techniques;Cells;Cessation of life;Child;childcare allowance;Chronic;Circulation;Clinical;Colorado;Communication;Congenital Heart Defects;constriction;cost;Critical Congenital Heart Defects;crosslink;cytotoxicity;cytotoxicity test;Defect;design;Development;Devices;Diameter;Echocardiography;elastomeric;Elastomers;Elements;Engineering;Evolution;Exhibits;Fellowship;Fiber Optics;Future;global health;Goals;Goretex;Growth;Health Care Costs;hemodynamics;Immune response;Implant;implantation;improved;improved outcome;In Vitro;in vivo;Infant;International;irradiation;Lasers;Life;Life Expectancy;Light;light scattering;light transmission;liquid crystal;Lung;Mechanics;Mediating;Medical Device;Medical Device Designs;medical implant;Medical Technology;Mentorship;minimally invasive;Morbidity - disease rate;mortality;Mus;nanocomposite;nanoGold;nanorod;Near-Infrared Spectroscopy;Newborn Infant;novel;Operative Surgical Procedures;Optics;outreach;palliate;palliation;palliative;patient prognosis;Patient-Focused Outcomes;Patients;Penetration;Performance;performance tests;Persons;Physiological;Polymer Chemistry;Polymers;preclinical study;pressure;Prevalence;Procedures;Publishing;Pulmonary artery structure;Pulmonary Hypertension;Quality of life;Regulation;Repeat Surgery;Reporting;Research Activity;Research Project Grants;Research Proposals;Research Training;response;Risk;scaffold;Scientist;Second Look Surgery;Shapes;skills;Skin;Source;Stimulus;subcutaneous;Surface;Surface Properties;Surgeon;surgery material;Technical Expertise;Techniques;Testing;Tissues;tool;Training;Translating;Translations;Transmission Electron Microscopy;United States;Universities;Work

PROJECT_TITLE: Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery band

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ORG_CITY: OAK RIDGE

ORG_NAME: UT-BATTELLE, LLC-OAK RIDGE NATIONAL LAB

ORG_STATE: TN

PHR: Project Narrative  The mechanisms underpinning heterogeneous metabolic response between individual cells remain poorly understood, though such mechanisms have ramifications across nearly all of medicine, e.g., disease detection, response to stress, treatment, and more. Most technologies lack the sensitivity, broad chemical coverage, quantitative capability, and/or the sampling throughput needed to enable the mechanisms of heterogeneous metabolic response of cells to be explored, but recently the development of single cell printing-liquid vortex capture-mass spectrometry (SCP-LVC-MS) has overcome many of these limitations. The goal of this research is to address key technical challenges regarding validation of the quantitative accuracy of SCP-LVC-MS, representativeness of SCP-LVC-MS measured cellular chemical profiles, and ability to relate SCP-LVC-MS measurements to established single-cell technologies so that it can become an effective research tool in the biomedical community and enable associations between metabolites and therapeutics to be investigated on an individual cellular basis for the first time.

PI_NAMEs: CAHILL, JOHN F (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Agreement;Area;Biological;Blood capillaries;Cell Cycle;Cell Nucleus;Cell Separation;Cells;Cellular Morphology;Cellular Structures;Chemicals;Chemistry;Chloroquine;Communities;Cytolysis;Dactinomycin;dalton;Data;Detection;Development;Diameter;Disease;Dyes;Ensure;Exposure to;Flow Cytometry;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Fluorescent Dyes;Goals;Growth;Hela Cells;HepG2;High Pressure Liquid Chromatography;high throughput analysis;imaging capabilities;imaging system;improved;Individual;insight;Label;Link;Lipids;Liquid substance;Lysosomes;Mammalian Cell;Mass Chromatography;Mass Spectrum Analysis;Measurement;Measures;Medicine;Metabolic;metabolomics;Methods;Morphologic artifacts;new technology;Nutrient;Optics;Organ;Pharmaceutical Preparations;Phenotype;Population;Printing;Process;protein expression;Proteins;Research;response;Rhodamine 123;Sampling;single cell technology;single molecule;small molecule;Solvents;Stress;success;System;Techniques;Technology;Therapeutic;Time;tool;treatment response;Validation;Work

PROJECT_TITLE: Development of Single Cell Printing-Liquid Vortex Capture-Mass Spectrometry for the Metabolic Profiling of Single Cells

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Similar to the addition of a negatively-charged phosphate to proteins during phosphorylation, sialylation adds a negatively-charged sialic acid to a glycoprotein to regulate conformation, clustering and cell surface retention. While this post-translational modification is known to regulate some protumorigenic cellular signaling and behaviors, roles in metabolism or brain tumors have not been determined. We seek to understand how sialylation and a specific sialyltransferase control brain tumor initiating cell maintenance and metabolism, which we expect will provide important insights that may be more broadly applicable to cancer biology and neurodevelopment.

PI_NAMEs: HJELMELAND, ANITA BORTON (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affinity;ALCAM gene;Area;Astrocytes;Behavior;beta-galactoside;Binding;Biological Assay;Biology;Brain;brain control;Brain Neoplasms;Brain Pathology;Cancer Biology;Cell Communication;Cell Differentiation process;cell growth;Cell Maintenance;Cell membrane;cell motility;Cell surface;Cell Surface Proteins;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;Charge;Chemoresistance;Data;Development;differential expression;Differentiation Antigens;effective therapy;Enzymes;experimental study;extracellular vesicles;Genetic;Glioblastoma;Glucose;Glucose Transporter;glucose uptake;GLUT-3 protein;Glycoproteins;glycosylation;Golgi Apparatus;Growth;Growth Factor Receptors;Human;improved;inhibitor;innovation;inorganic phosphate;insight;Integrins;Invaded;knock-down;Lectin;Link;Maintenance;Malignant Childhood Neoplasm;Measures;Mediating;Mediator;Messenger RNA;Metabolic;Metabolism;metabolome;migration;Modification;Molecular Conformation;Molecular Mechanisms of Action;Mus;Nature;neoplastic cell;nerve stem cell;neurodevelopment;Neuronal Plasticity;Neurons;Neurosphere;novel;Nutrient;nutrient deprivation;Oligosaccharides;paralogous gene;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Polysaccharides;Post-Translational Protein Processing;Property;protein expression;protein function;Protein Glycosylation;protein structure;Proteins;Proteomics;Publishing;receptor;Research;Resistance;Role;self-renewal;Sialic Acids;sialylation;Sialyltransferases;Signal Transduction;Site;SLC2A1 gene;stem;stem cells;stemness;temozolomide;Therapeutic Intervention;therapy resistant;Tumor Biology;tumor growth;tumor initiation;tumor metabolism;tumorigenic

PROJECT_TITLE: Sialylation in the Maintenance and Metabolic Plasticity of Neural Stem Cell-Like Brain Tumor Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: READD-ADSP Alzheimer Disease (AD) is the most common neurodegenerative disease in the US, occurring in more than 35% of individuals above the of age 85. While there are currently no effective pharmacological treatments for preventing or delaying the onset of AD, genomic studies are a proven approach for identifying new therapeutic targets. The goal of the ʺRecruitment and Retention for Alzheimerʹs Disease Diversity Cohorts in the ADSPʺ (READD-ADSP) is to build a resource that greatly expands the representation of currently underrepresented African ancestry and Hispanic/Latinx (HL) individuals in AD genetic studies, which will expand our understanding of the genetic etiology of AD and broaden the biological scope for developing potential therapies.

PI_NAMEs: BUSH, WILLIAM S;BYRD, GOLDIE S.;HAINES, JONATHAN L;KUNKLE, BRIAN WILLIAM;PERICAK-VANCE, MARGARET A. (contact);REITZ, CHRISTIANE ;TOSTO, GIUSEPPE ;VANCE, JEFFERY MARVIN

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;adjudication;Admixture;Africa;African;African American;African American population;African ancestry;African Caribbean;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Biocompatible Materials;Biological;Biological Assay;Biological Markers;Caribbean Hispanic;Clinical;Clinical assessments;Clinical Data;cohort;Communities;Data;Data Collection;Database Management Systems;Dementia;Diagnosis;Disease;disease phenotype;DNA;druggable target;Elderly;electronic data capture system;Ethnic Origin;Ethnic Population;European ancestry;Evaluation;Follow-Up Studies;Future;Gene Expression;Genetic;genetic architecture;Genetic Diseases;Genetic Predisposition to Disease;genetic risk factor;Genetic study;Genetic Variation;genome resource;genome sequencing;genome-wide analysis;Genomic approach;Genomics;Genotype;Goals;Heterogeneity;Hispanic;human subject protection;improved;Individual;Infrastructure;Latinx;Latinx population;Maps;Neurocognitive;Neurodegenerative Disorders;new therapeutic target;Not Hispanic or Latino;Participant;Performance;Pharmacological Treatment;Phase;Phenotype;phenotypic data;Plasma;Population;Population Genetics;precision medicine;prevent;Prevention;Procedures;Process;racial diversity;racial population;recruit;Research;Research Personnel;Resources;Risk;risk variant;RNA;Sampling;Site;SNP array;Testing;transmission process;Underserved Population;Whole Blood;whole genome

PROJECT_TITLE: Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Therapies for circadian rhythm disruption, which is common both in the general and clinical populations with irregular sleep-wake schedules rely on a single biomarker – the melatonin rhythm – to guide the timing of interventions such as bright light exposure even though circadian rhythms are ubiquitous across physiological systems. We have found that a combined intervention of light exposure and meals shifts the timing of the circadian rhythms in circulating cholesterol and triglycerides in humans, and we propose a randomized controlled trial in healthy young adults to determine the individual roles of light exposure and time restricted eating as the primary time cues for resetting the circadian rhythms of these lipids and melatonin, thereby construct phase response curves that define the relationship between the timing of these two interventions and the change in the timing of circadian rhythms in circulating lipids and melatonin. The knowledge gained will provide novel insight on the fundamental properties of the human circadian system and have potentially broad public health and clinical implications including recommendations for developing healthy light exposure and eating schedules and guiding current and future treatment strategies to address circadian disruption in multiple circadian systems.

PI_NAMEs: RAHMAN, SHADAB A (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Animal Model;Area Under Curve;Biological Markers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cholesterol;Chronic;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Clinical;Cues;Data;design;Development;Disease;Dyslipidemias;Eating;Evaluation;Event;experience;Future;General Population;Goals;Health;High Prevalence;Hour;Human;Individual;insight;Intervention;Jet Lag Syndrome;Knowledge;Light;lipid metabolism;lipidome;lipidomics;Lipids;Measures;Mediating;Melatonin;Meta-Analysis;Metabolism;metabolomics;novel;Patients;Peripheral;Phase;Phase response curves;Phototherapy;Physiological;Pilot Projects;pilot trial;Plasma;Population;primary outcome;Property;Public Health;public health relevance;Randomized;Randomized, Controlled Trials;Recommendation;Recurrence;Reporting;Resources;response;Risk;Role;Schedule;shift work;Sleep;Sleep Deprivation;Sleep disturbances;social;Stimulus;System;Therapeutic;therapeutic target;Time;Time-restricted feeding;treatment strategy;Triglycerides;Work;young adult

PROJECT_TITLE: Determining The Role of Photic and Non-Photic Time Cues in Resetting Lipid Circadian Rhythms in Humans

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: PERICAK-VANCE, MARGARET A. (contact)

PROJECT_TERMS: Address;Advisory Committees;African;African American;Aging;Agreement;Alzheimer's Disease;Amendment;Awareness;Budgets;Clinical;cohort;Collaborations;Communication;Communities;Complex;Data;Data Set;data sharing;Dementia;Development;diverse data;Elements;Ensure;experience;Feedback;functional genomics;Funding;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;Genetic Variation;Genomics;Goals;Head;Hispanic;human subject protection;Individual;Infrastructure;Institution;Institutional Review Boards;inter-institutional;International;Latinx population;Lead;Machine Learning;meetings;Minority;Minority Groups;Monitor;Nature;neuropathology;Neuropsychology;Not Hispanic or Latino;Occupational activity of managing finances;Participant;Persons;Population;post-doctoral training;Press Releases;Principal Investigator;Protocols documentation;Publications;Recommendation;recruit;Research;Research Personnel;Resources;response;Role;Sampling;Scientist;Site;symposium;Underserved Population;United States National Institutes of Health;video chat;web site;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PROJECT_TITLE: Core B: Outreach, Ascertainment, and Data Collection


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_DEPT: CHEMISTRY

PHR: NARRATIVE/Public Health Relevance Statement Individuals with Down syndrome experience chronic inflammation because of hyper-sensitivity to molecules called interferons, which activate immune responses to infections. In this study, we seek to apply diverse and complementary approaches to study two human enzymes that have recently been shown to drive these interferon responses. We anticipate that the mechanistic insights gained will establish the clinical potential of these druggable enzymes as antagonists of inflammatory interferons, which may yield new therapeutic strategies for DS and its co-morbidities, such as auto-immune disorders.

PI_NAMEs: TAATJES, DYLAN J (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;Address;Affect;Age;antagonist;Area;Autoimmune Diseases;B lymphocyte immortalization;Basic Science;biobank;Biochemical;Biological Assay;Cells;Chromosome 21;Chronic;Classification;Clinical;Code;comorbidity;Complement;Complex;cortistatin;cytokine;Defect;Dependence;Development;DNA Binding;Down's Syndrome;druggable target;Ensure;Enzymes;Equilibrium;experience;experimental study;Foundations;Gene Expression;General Population;Genes;Genetic Transcription;genome-wide;Goals;high reward;high risk;Human;Human Genome;Hyperactivity;Hypersensitivity;immune function;Immune response;Immunity;In Vitro;Individual;Infection;Inflammation;Inflammatory;inhibitor;insight;Interferon Activation;interferon antagonist;Interferon Receptor;Interferons;Link;Mediator;Metabolism;metabolomics;Methods;Molecular;new therapeutic target;novel therapeutic intervention;Nuclear;paralogous gene;Pathway interactions;Phosphotransferases;Polymerase;Precision Run-On Sequencing;programs;promoter;Proteins;public health relevance;Reagent;Regulation;Repression;Research Personnel;response;RNA Polymerase II;RNA Splicing;Role;Runaway;Sampling;scaffold;sex;Siblings;Signal Transduction;Solid;Spliced Genes;STAT1 gene;Stimulus;System;Testing;Therapeutic;therapeutic target;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Untranslated RNA

PROJECT_TITLE: Mediator kinases as interferon antagonists in Down Syndrome

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: CUCCARO, MICHAEL L (contact)

PROJECT_TITLE: Core C: Adjudication and Phenotype Harmonization


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: GRISWOLD, ANTHONY JOHN (contact)

PROJECT_TERMS: adjudication;African;African American;Alzheimer's Disease;Alzheimer’s disease biomarker;analytical method;Basic Science;biobank;Biocompatible Materials;Bioinformatics;bioinformatics pipeline;Biological Markers;Blood;cohort;Communities;Cuban;Data;Data Analyses;data dissemination;data management;Data Set;data sharing;data standards;Dementia;DNA;Ensure;experience;Freezing;Future;Gene Expression Profiling;Genetic Variation;Genome;genome-wide;Genomics;Genotype;Goals;Hispanic;human genomics;Individual;instrumentation;Latinx;Light;Molecular Profiling;neurofilament;Nigerian;phenotypic data;Plasma;Play;Process;Protocols documentation;Quality Control;recruit;Research;Resources;RNA;Role;sample collection;Sampling;screening;Shipping;Site;SNP array;Standardization;tau Proteins;Technology;Translational Research;Tube;Whole Blood;Work

PROJECT_TITLE: Core D: Genomics and Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: KUNKLE, BRIAN WILLIAM (contact)

PROJECT_TERMS: adjudication;Alzheimer's Disease;analysis pipeline;biobank;Biological;Biological Markers;Clinical Data;clinical phenotype;Cloud Computing;Cognitive;cognitive testing;cohort;Collaborations;Communities;Computer software;dashboard;Data;Data Analyses;data management;Data Set;Data Storage and Retrieval;database of Genotypes and Phenotypes;demographics;diverse data;Ensure;Follow-Up Studies;Funding;Future;Genetic;Genetic Variation;genome sequencing;genomic data;Genomics;Genotype;Goals;Individual;Information Resources;Infrastructure;Medical History;outreach;Patient Recruitments;Performance;Phenotype;phenotypic data;Population;Process;Production;Recording of previous events;recruit;Research;Resources;Running;Sampling;Source;Test Result;therapeutic development;Update;web site;whole genome;Work

PROJECT_TITLE: Core E: Data Management


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Huntington’s disease is a devastating and fatal neurodegenerative disorder for which there is no cure or effective treatment. The combination of emotional, cognitive and motor symptoms, leading to long-term care needs results in an extremely high healthcare cost, estimated at 25 billion dollars a year. This study is aimed at understanding how the disease process is modified, with the potential of discovering novel targets for therapeutic intervention prior to disease onset.

PI_NAMEs: SEONG, IHN SIK ;WHEELER, VANESSA C (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Age;Age of Onset;Alleles;Binding;Biochemical;Biological Assay;Biological Process;Biology;brain tissue;CAG repeat;cell free DNA;Cells;Cellular Stress;Cessation of life;Chromosomes;Clinical;Complex;CRISPR-mediated transcriptional activation;Data;Disease;DNA Damage;DNA Ligases;DNA Ligation;DNA Repair;DNA Sequence Alteration;effective therapy;emotional symptom;experimental study;Family;functional outcomes;gene discovery;Gene Modified;Gene Mutation;Genes;genetic manipulation;Genetic Recombination;Genetic Transcription;Genetic Variation;genome wide association study;Haplotypes;Health Care Costs;Histologic;Homologous Gene;Human;Human Genetics;Huntington Disease;Huntington gene;induced pluripotent stem cell;Inherited;insight;Knock-in Mouse;Length;Ligase;Long-Term Care;Mass Spectrum Analysis;Modeling;Modification;Molecular;motor symptom;mouse model;multiplex assay;Mus;mutant;Mutation;nerve stem cell;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;new therapeutic target;novel;Nuclear;Onset of illness;Pathogenesis;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;Patients;Phenotype;Process;protein purification;Proteins;repaired;Research;response;Role;seal;Series;Structure;Substrate Specificity;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Toxic effect;transcriptome;Up-Regulation;Variant;X-Ray Crystallography

PROJECT_TITLE: Dissecting the role of DNA Ligase 1 in Huntington's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: BUSH, WILLIAM S (contact)

PROJECT_TERMS: Accounting;Address;adjudication;African;African American;African American population;African Caribbean;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;Biological;Biological Markers;Caribbean Hispanic;Cells;Chromosomes;clinical practice;Code;cohort;Communities;Complex;Custom;Data;Data Collection;data management;Disparity;Economics;Enrollment;Epigenetic Process;Ethnic Population;Genes;Genetic;genetic architecture;genetic risk factor;genetic testing;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Goals;health disparity;Health Policy;Heritability;Hispanic;improved;Latinx;Latinx population;Localized Disease;Methods;Modeling;Molecular;multi-ethnic;Neurodegenerative Disorders;Not Hispanic or Latino;novel;outreach;Participant;Pathway Analysis;Pathway interactions;Phenotype;Population;Population Heterogeneity;predictive modeling;Public Health;racial population;recruit;Regulatory Element;Resources;Risk;Risk Factors;Sample Size;Sampling;Site;social;Standardization;Statistical Data Interpretation;Testing;Tissues;Trans-Omics for Precision Medicine;transcriptome;Variant

PROJECT_TITLE: Project 1: Genetic Discovery Within Diverse Ancestry Cohorts


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: TOSTO, GIUSEPPE  (contact)

PROJECT_TERMS: admixture mapping;Affect;African;African American;African American population;African ancestry;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Awareness;Biology;causal variant;cohort;Cuban;Detection;Disease;Dissection;Ethnic Origin;Ethnic Population;Etiology;European;European ancestry;Event;Exhibits;Genes;Genetic;genetic architecture;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome-wide;genomic data;genomic locus;Genomic Segment;Genomics;High Prevalence;Hispanic;Incidence;Individual;Inherited;Latinx;Linkage Disequilibrium;Maps;Meta-Analysis;Modeling;multi-ethnic;Native American Ancestry;Native Americans;Not Hispanic or Latino;novel;Output;Pattern;phenotypic data;Population;Population Heterogeneity;Prevalence;protective allele;Puerto Rican;rare variant;Recording of previous events;recruit;Research;Resources;Risk;risk variant;Role;Shapes;Testing;Variant;variant detection;Work

PROJECT_TITLE: Project 2: Multi-Ethnic Analysis for Alzheimer Disease


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This proposal will extend our existing University of Michigan IRACDA program. Through a partnership with both Henry Ford College and Wayne County Community College District, our IRACDA program trains postdoctoral fellows in both research and teaching. The overarching goal is to diversify the academic workforce and encourage more students from these colleges to pursue four-year degrees in STEM.

PI_NAMEs: BROOKS, SUSAN V;SEPT, DAVID  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: career;cohort;college;Communities;community college;County;Development;Education;education research;Educational process of instructing;Engineering;equity, diversity, and inclusion;experience;Faculty;faculty mentor;Funding;Future;Future Teacher;Generations;innovation;Inosine Diphosphate;Institution;instructor;Laboratories;Learning;learning materials;Mathematics;member;Mentors;Mentorship;Michigan;Paper;peer;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Program Evaluation;programs;Publishing;Recording of previous events;Records;Reproducibility;Research;Research Project Grants;Research Training;Scholarship;Science;Scientist;Secure;Students;success;Teacher Professional Development;Technology;Time;Training;Underrepresented Minority;underrepresented minority student;Universities;university student;Work

PROJECT_TITLE: Michigan IRACDA: Diversifying the Future Academic Workforce in STEM

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]