NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PLASTIC SURGERY

PHR: Project Narrative Traumatic brain injury (TBI) is a leading cause of death and disability, with an estimated 1.5 million Americans sustaining a TBI each year. Although decompressive craniectomy is a lifesaving procedure in severe TBI, subsequent replacement of the cryopreserved autogenous bone to reconstruct the critical size skull defect is accompanied by a high risk of resorption and failure. This proposal aims to utilize a novel mouse model to further delineate the mechanisms of cryopreserved calvarial bone healing and failure, and to implement an innovative, nanotransfection- based vasculogenic cell reprogramming approach to revascularize cryopreserved bone during cranioplasty.

PI_NAMEs: MITCHELL, KERRY-ANN STEWART (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: American;Animal Model;Biology;Biomechanics;Blood Vessels;bone;bone healing;Bone Morphogenetic Proteins;bone reconstruction;Bone Regeneration;Bone Resorption;Bone Substitutes;Bone Tissue;Bone Transplantation;Brain;Brain Edema;C57BL/6 Mouse;Calvaria;career;career development;Caring;Cause of Death;Cell Reprogramming;Cell Survival;Cell Therapy;Cells;Cephalic;Cerebral Revascularization;Clinical;Control Groups;Coupled;cranium;cranium plastic repair;Cryopreservation;Data;Defect;Deterioration;disability;Economic Burden;Endothelial Cells;Engineering;experience;Failure;Fibroblasts;fibula;Foundations;FOXC2 gene;functional improvement;gene therapy;healing;high risk;Human;Immunohistochemistry;Impairment;improved;innovation;Intracranial Pressure;Ischemic Stroke;Length of Stay;Life;limb ischemia;Manuscripts;Mechanics;Medical;Mentors;Mentorship;Mesenchymal Stem Cells;Methodology;microCT;Modeling;mouse model;Mus;nanotechnology platform;nanotransfection;Neurologic;non-viral gene delivery;novel;Ohio;operation;Operative Surgical Procedures;Osseointegration;Patients;Perfusion;Peripheral Nerves;Positioning Attribute;Postoperative Period;Preparation;pressure;Procedures;Process;professor;Program Development;Property;reconstruction;Recovery of Function;repaired;Research;Research Personnel;restoration;revascularization;Rodent Model;Role;sciatic nerve injury;Scientist;Site;skills;Study models;success;Surgeon;Technology;tenure track;Testing;therapeutic evaluation;tissue degeneration;Tissue Donors;Tissue Engineering;Tissues;Training;transcription factor;translational approach;Traumatic Brain Injury;United States National Institutes of Health;Universities;Vascular blood supply;Vascularization;vasculogenesis;Vasculogenic;Viral Vector;Work

PROJECT_TITLE: Nanotransfection-based Cell Reprogramming to Drive Bone Revascularization in a Novel Mouse Model of Autogenous Cranioplasty

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (09)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Radiation Oncology;Social Determinants of Health;Women's Health Research

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Public Health Relevance Each year hundreds of thousands of the nearly 4 million breast cancer survivors in the US experience severe storms. Despite a growing recognition that severe storms disrupt cancer treatment and increase the risk for acute and long-term health complications, there is a knowledge gap regarding which populations of patients with breast cancer are most vulnerable to severe storms and strategies that may be implemented to mitigate care disruption and respond to health needs. This study will examine the impact of severe storms on cancer care and health outcomes of patients with breast cancer and engage with diverse stakeholders to identify and prioritize strategies to be implemented to improve health services and outcomes among patients with breast cancer following severe storms.

PI_NAMEs: BATES, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute;acute care;Address;Administrator;Affect;American;American Society of Clinical Oncology;Breast;Breast Cancer Patient;Breast Cancer survivor;cancer care;Cancer Patient;cancer therapy;care systems;career;career networking;Caring;Cause of Death;climate change;Climatology;Communities;community engagement;comorbidity;Data;Databases;Diagnosis;disadvantaged background;Disasters;Early Diagnosis;Education;Electricity;Emergency Situation;Environmental Health;Environmental Impact;Environmental Wind;Ethnic Origin;Evaluation;evidence base;experience;Floods;Foundations;frailty;Future;Goals;Health;health care delivery;Health Services;Health Services Research;Health system;Heat Waves;high risk population;Home;human old age (65+);Hurricane;implementation science;implementation strategy;improved;Intervention;intervention mapping;Intervention Studies;Interview;Knowledge;Learning Module;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Mediation;Mediator;Mentors;Mentorship;Methods;mortality;mortality risk;Natural Disasters;Neoadjuvant Therapy;Oncology;Outcome;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Persons;Physicians;Policies;Population;Precipitation;Prevalence;Prognosis;Public Health;public health relevance;Publishing;Quality of Care;Race;Radiation Oncology;Radiation therapy;Readiness;receptor;Recording of previous events;Research;Research Proposals;Risk;Scientist;Severities;skill acquisition;skills;Societies;Socioeconomic Status;Speed;Subgroup;Training;Treatment Protocols;Visit;Vulnerable Populations;Woman;working group

PROJECT_TITLE: Evaluating, Preparing, and Responding to Care Disruptions and Health Outcomes Among Patients with Breast Cancer Following Severe Storms

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Viral infections are a leading cause of early-life morbidity and mortality, and CD8 T cells are a crucial component of adaptive immunity responsible for combating viruses and conferring immunological memory. This project aims to understand the role of intrinsically high PI3K/mTOR signaling in early-life CD8 T cells and how this pathway contributes to metabolic and functional peculiarities of early-life T-cell responses in health and severe viral illness. This research will lead to further insights into how early-life CD8 T cells differ functionally from young adults and what pathways could serve as targets for therapies to improve early-life immune responses to infection and vaccination.

PI_NAMEs: BRODSKY, NINA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 5 year old;Acute;adaptive immune response;adaptive immunity;Adult;ATAC-seq;Automobile Driving;Autopsy;Biology;Bronchiolitis;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Differentiation process;Cell Physiology;Cells;Cessation of life;Child;Childhood;Chromatin;Critical Care;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Death Rate;Development;differential expression;Disease;Doctor of Medicine;early childhood;Effector Cell;Enzyme-Linked Immunosorbent Assay;Exhibits;experimental study;Flow Cytometry;FRAP1 gene;Future;Gene Mutation;Genetic Transcription;Glycolysis;Goals;Health;Hospitalization;Human;Hyperactivity;Immune;Immune response;immunodeficiency;Immunologic Memory;Immunologics;immunopathology;improved;improved outcome;In Vitro;Infant;Infection;insight;interest;Intervention;K-Series Research Career Programs;Life;life span;Lung;Lymphopenia;Measures;Mediating;medical schools;Memory;Mentors;Metabolic;Metabolism;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mTOR Inhibitor;mTOR Signaling Pathway;Neonatal;neonatal human;Neonatal Mortality;neonatal period;neonate;novel;novel therapeutics;Onset of illness;Outcome;Outpatients;pathogen;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Phosphatidylinositols;Phosphotransferases;PIK3CG gene;Predisposition;prevent;Principal Investigator;Production;professor;programs;Proliferating;Property;Recovery;Regulation;Research;Research Methodology;Respiratory syncytial virus;response;Role;Sampling;senescence;Serum;Severities;Severity of illness;Signal Transduction;skills;Specimen;Syndrome;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Therapeutic;TNF gene;transcriptome sequencing;Translational Research;translational therapeutics;Universities;Vaccination;vaccination outcome;Viral;Viral Bronchiolitis;Virus;Virus Diseases;Visit;Work;World Health Organization;young adult

PROJECT_TITLE: Targetable pathways driving sub-optimal early-life CD8 T cell responses

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Telehealth;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative Domestic violence is highly prevalent in low-and middle-income countries, including India (41%), but the public health system lacks a psychosocial response for DV-linked posttraumatic stress disorder (PTSD) and depression, leading to over 90% treatment gaps. This project addresses an urgent public health need by developing and testing a transdiagnostic single-session intervention with follow-up mHealth support (via an interactive chatbot) in primary health clinics in Goa, India. As this project combines two low-intensity intervention formats to address engagement and adherence challenges, uses non-specialist providers to address expert provider shortages, and capitalizes on the ubiquity of mobile phones to strengthen follow-up skills practice, we expect this study to greatly improve effective coverage for DV survivors with PTSD and depression and contribute to the NIMH priority area of global mental health research on designing and evaluating interventions that can be integrated into routine care settings.

PI_NAMEs: PATEL, ANUSHKA RAJESH (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Area;arm;base;brief intervention;care systems;career;Caring;Case Series;Cellular Phone;chatbot;Clinic;Clinical;clinical effect;Communities;Community Healthcare;comorbidity;cost;Data;design;Diagnostic;Disease;Domestic Violence;Dropout;Economics;Educational workshop;Effectiveness;Elements;emotion dysregulation;emotion regulation;Emotions;Environment;Evaluation;evidence base;Evidence based intervention;Exposure to;Family Violence;Feedback;Fellowship;follow-up;Fostering;Future;Goals;Health;health care service utilization;health care settings;Health system;High Prevalence;Home;improved;India;Individual;Intervention;intervention effect;intervention refinement;Interview;intimate partner violence;Legal;Life;Link;low and middle-income countries;Memory;Mental Depression;Mental Health;mental health organization;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mHealth;Modeling;Mood Disorders;mood symptom;Motivation;National Institute of Mental Health;North America;novel;Participant;Penetration;Persons;Population;Post-Traumatic Stress Disorders;Primary Care;Process;promote resilience;Protocols documentation;Provider;Psychiatric Social Work;Psychiatric therapeutic procedure;psychoeducation;psychologic;psychosocial;Psychosocial Assessment and Care;Public Health;Public Health Schools;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Project Grants;Resource-limited setting;Resources;response;Risk Factors;routine care;satisfaction;Services;Side;Site;skills;social stigma;Specialist;stress symptom;success;suicidal;Suicide;support tools;Surveys;Survivors;Symptoms;Testing;Text;therapy design;therapy development;Time;Training;Trauma;trauma exposure;traumatic stress;treatment as usual;user centered design;Violence;virtual;Woman;Youth

PROJECT_TITLE: Designing and evaluating a Single-session Transdiagnostic intervention for Emotion Regulation with follow-up mHealth support for domestic violence survivors in India.

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Kidney Disease;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Chronic kidney disease (CKD) is highly prevalent and progresses faster in older adults, leading to a substantially higher risk for end-stage kidney disease, poor quality of life and mortality. This study will elucidate pathophysiologic mechanisms that lead to accelerated kidney function decline in older patients with CKD. The results of this study have the potential to identify new treatment targets to improve survival and quality of life in older adults with CKD.

PI_NAMEs: JEONG, JINHEE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adrenergic Agents;Adrenergic beta-Antagonists;Adult;Affect;Aging;Animal Model;Arithmetic;aspirate;blood oxygen level dependent;Blood Vessels;career development;carvedilol;Chronic;Chronic Kidney Failure;Clinical;Clinical Investigator;clinical prognosis;Clinical Research;Clinical Sciences;comorbidity;Computerized Medical Record;contrast imaging;Data;design;Deterioration;Development;Development Plans;Dialysis procedure;didactic education;Disease Progression;disorder control;Doppler Ultrasound;Elderly;End stage renal failure;experience;Foundations;functional decline;Funding;Future;Geriatrics;Goals;Grant;Growth;Health;Health Care Costs;hemodynamics;High Prevalence;high risk;high risk population;Human;human old age (65+);imaging biomarker;Imaging Techniques;Impairment;improved;in vivo;Incidence;innovation;insight;Intervention;Investigation;Kidney;Kidney Diseases;Kidney Failure;Laboratory Research;Lead;Link;longitudinal, prospective study;Magnetic Resonance;Magnetic Resonance Imaging;Master of Science;Measurement;Measures;Mediating;Medical;Mentors;Mentorship;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Muscle;Nephrology;Nerve;neural;neurovascular;new therapeutic target;novel;older adult;older patient;Outcome;Patient Care;patient prognosis;Patients;Perfusion;Peripheral;Phase;Physiology;Predisposition;Prevalence;Prevention strategy;programs;prospective;Prospective Studies;Proteinuria;Psyche structure;Quality of life;receptor;Reflex action;Renal Blood Flow;renal damage;Renal function;renal hypoxia;renal ischemia;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;response;Rest;Risk;Risk Factors;risk stratification;Role;Signal Pathway;skills;Stress;Sympathetic Nervous System;Sympatholytics;Testing;Time;tissue oxygenation;tool;Training;Translational Research;translational scientist;Translations;treatment strategy;United States National Institutes of Health;Universities;vasoconstriction

PROJECT_TITLE: Neurovascular Mechanisms of Kidney Disease Progression in Older Adults

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Amidst the grave and worsening national overdose crisis, individuals with a history of recent incarceration face significant barriers to receiving evidenced-based medication and are at increased risk for death when compared to the general population. Telehealth is one potential strategy to address gaps in treatment clinician availability, competing social determinants of health, and access inequities by providing flexible, low-cost, and low-threshold access to treatment linkage after release from incarceration. This study will identify predictors of failed post-release treatment engagement among individuals with recent incarceration and intervene with a telehealth innovation, which has great potential to decrease overdose mortality and improve health outcomes for this marginalized population.

PI_NAMEs: KHATRI, UTSHA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Administrator;Adult;Ambulatory Care;Award;Buprenorphine;buprenorphine treatment;care delivery;career;Caring;Caucasians;Clinic Visits;Clinical;clinical center;clinical outcome assessment;Clinical Protocols;Clinical Skills;Clinical Trials;Communities;Community Healthcare;community setting;Conduct Clinical Trials;cost;criminal behavior;Data;Data Set;Dedications;design;Development;Disparity;Enrollment;Epidemiology;evidence base;Evidence based treatment;experience;Face;feasibility trial;flexibility;Funding;Future;General Population;Goals;Grant;Health;health care service utilization;health equity;Health Insurance;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;high risk;Housing;housing instability;Imprisonment;improved;Individual;Inequity;innovation;Intervention;intervention delivery;intervention mapping;Jail;Knowledge;Lead;Legal;Legal system;Link;marginalized population;Measures;medication for opioid use disorder;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentorship;Morbidity - disease rate;mortality;mortality risk;National Institute of Drug Abuse;Needs Assessment;novel;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Patient Participation;Patients;Perception;Persons;Pharmaceutical Preparations;probation;Productivity;programs;Protocols documentation;Provider;psychiatric comorbidity;Public Health;Randomized, Controlled Trials;recidivism;Recording of previous events;recruit;Research;Research Personnel;retention rate;Risk;Sampling;satisfaction;Schedule;skills;social competition;social health determinants;Social Network;social stigma;Social support;Structure;substance use;Supervision;Surveys;Target Populations;telehealth;Testing;theories;Training;Training Activity;Transportation;treatment adherence;treatment as usual;Treatment Efficacy;treatment program;trial comparing;uptake;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Telehealth to Improve Post-Incarceration Treatment for OUD Patients (TIPTOP): AnAcceptability and Feasibility Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PISCATAWAY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Touch-evoked pain (allodynia) is a common symptom in persistent pain conditions, affecting a significant percentage of individuals after surgeries (e.g. mastectomy, thoracotomy, hernia repair, cesarean) and chemotherapy treatment. This project aims to determine how altered coding within the dorsal column nuclei, an integral brainstem region for tactile processing, shapes the activity of downstream circuits to promote touch- evoked pain following injury. An improved understanding of these circuits will facilitate the development of improved therapeutics for the treatment of persistent pain.

PI_NAMEs: GRADWELL, MARK  (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Ablation;Address;Affect;Affective;Afferent Neurons;allodynia;Amyloid beta-Protein;Anatomy;Anesthetics;antinociception;Applications Grants;Attenuated;awake;Behavior;Behavioral;Brain;Brain Stem;career development;Cell Nucleus;Cesarean section;chemotherapy;Chemotherapy-induced peripheral neuropathy;Code;common symptom;Coupled;Data;Development;Disease;dorsal column;Electric Stimulation;Electrophysiology (science);Equilibrium;excitatory neuron;Exhibits;Foundations;Funding;Future;Health;Hernia;Hyperactivity;Image;improved;in vivo;Individual;inhibitor;inhibitory neuron;Injury;insight;K-Series Research Career Programs;Lateral;Lead;Lesion;machine vision;Maps;Mastectomy;Mechanoreceptors;Mediator;Mentors;Mentorship;midbrain central gray substance;Midbrain structure;Motivation;Mus;nerve injury;neural;neural circuit;neural network;Neurons;Neuropathy;Neurosciences;novel;Operative Surgical Procedures;optogenetics;Output;Pain;pain behavior;pain model;pain perception;pain reduction;patch clamp;Pathway interactions;Persistent pain;Pharmacology;Phase;Play;Population;postsynaptic;preference;presynaptic;programs;recruit;repaired;Research;Role;Sensory;serial imaging;Shapes;Signal Transduction;Slice;Speed;Spinal;Stimulus;Structure;Tactile;Techniques;Testing;Thalamic structure;Therapeutic;Thoracotomy;Time;tool;Touch sensation;Training;training opportunity;transmission process;United States National Institutes of Health;Universities;Ventral Lateral Thalamic Nucleus;Ventral Posterolateral Nucleus;Viral;Washington;Work

PROJECT_TITLE: The Role of Distinct Dorsal Column Nuclei Outputs in Persistent Pain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Black women are disproportionately exposed to severe, long-term intimate partner violence (IPV), putting them on the trajectory for experiencing a protracted course of depression. Existing and long-standing inequities within the mental healthcare system make it especially difficult for them to obtain immediate depression care; however, partnering with trusted resources like the Black church may be a means of supporting this vulnerable, difficult- to-reach and underserved population of IPV survivors. Guided by a community-partnered participatory approach and Waller’s Help-Seeking Model, this proposed K23 site-randomized pilot feasibility trial will employ ADAPT- ITT and the PRISM framework to contextually tailoring and implementing a brief, evidence-based intervention for Black women IPV survivors with the depression that will be delivered by church leaders in a novel faith-based setting.

PI_NAMEs: WALLER, BERNADINE  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Affect;Behavior Control;Belief;Black church;Black Populations;Black race;black women;care systems;career;Caring;Child Care;Church;Clergy;Cluster randomized trial;Communities;community based participatory research;community engaged approach;community partners;community setting;contextual factors;Counseling;Data;Depressed mood;depressive symptoms;design;disability;Disproportionately impacts women;Early Diagnosis;Early treatment;Education;Evidence based intervention;experience;Exposure to;Faith;feasibility trial;Future;Gender;General Population;Health Personnel;Healthcare promotion;Healthcare Systems;help-seeking behavior;Homicide;implementation framework;implementation outcomes;implementation research;implementation science;improved;improved outcome;Individual;innovation;interpersonal therapy;Interruption;intersectionality;Intervention;Interview;intimate partner violence;long-standing disparities;Measures;Mediating;Mediation;member;men;Mental Depression;Mental Health;mental health policy;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Modeling;National Institute of Mental Health;New York;novel;Outcome;Pathway interactions;patient oriented;patient oriented research;Personal Satisfaction;Politics;Population;preference;Process;Provider;psychologic;psychological distress;Public Health;Race;racial disparity;Randomized;randomized trial;Religion;Research;Resources;Risk;Service delivery model;Services;Site;Social Functioning;Social Responsibility;Social support;Source;Spirituality;Stress;Structure;Survivors;sustainability framework;Testing;Therapeutic;Time;Training;treatment adherence;Trust;Underserved Population;United States;Victimization;Vulnerable Populations;White Women;Woman;Work

PROJECT_TITLE: Increasing Access To Depression Care For Black Women Survivors Of Intimate Partner Violence


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Advances in nanomedine and synthetic biology have brought us ever so close to attain the “magic bullet” against cancer. However, targeted delivery of drugs to tumors is still challenging for the most advanced technologies we have. This proposal aims to combine approaches from nanomedicine and synthetic biology to create highly cooperative system that can be useful for cancer therapy.

PI_NAMEs: HAHN, JAESEUNG  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Active Learning;Affect;Agreement;Angiotensin II Receptor;anti-cancer research;Bacteria;Bacterial Genes;Bacterial Toxins;Binding;Biological;Blood;Blood Vessels;Breast Cancer Model;Cancer Model;cancer therapy;career;career development;Carrying Capacities;Cell surface;Chemicals;Colorectal Cancer;Communities;Complex;Data;delivery vehicle;design;design and construction;Development;Development Plans;Devices;Disease;Disparate;Doctor of Philosophy;Drug Delivery Systems;Drug Targeting;Educational workshop;Engineering;Ensure;Environment;Epitopes;Escherichia coli;experience;Extracellular Matrix;Extracellular Matrix Degradation;Foundations;Genetic;Goals;Heterogeneity;Hour;immune checkpoint blockade;Immunology;Immunotherapy;improved;In Situ;In Vitro;in vitro Model;in vivo;Individual;inhibitor;insight;Intravenous;Iron;iron oxide nanoparticle;Joints;Knowledge;Leadership;Ligands;lymphatic drainage;Magic;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Medical;Mentors;Mentorship;Microfluidic Microchips;Modality;Modeling;Modernization;Molecular;mouse model;nanobodies;nanomedicine;nanoparticle;nanoparticle delivery;nanoparticle drug;Nanotechnology;Nature;novel;Olives - dietary;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Peptides;Perfusion;Permeability;pharmacokinetics and pharmacodynamics;Physics;Postdoctoral Fellow;Prevalence;Probiotics;Production;Profibrotic signal;programs;Property;rational design;Reporting;Research;Research Activity;Research Personnel;Resources;Scientist;Signal Pathway;Site;skills;Solid Neoplasm;synergism;synthetic biology;System;Tannic Acid;targeted delivery;targeted treatment;Technical Expertise;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic nanoparticles;trafficking;Training;Training Activity;Translations;Treatment Efficacy;tumor;tumor microenvironment;Universities;Vision;Work

PROJECT_TITLE: Programmable biohybrid system for cancer therapy

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Precision Medicine;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Morbidity and mortality in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are due both to disease manifestations and complications of immunosuppressive therapy. There is an urgent need for markers of disease activity to inform management strategies that better balance benefits and risks of treatment. We hypothesize that monocytes, key regulators of a multitude of immune responses, play an important role in vasculitis pathogenesis, that alpha-1 antitrypsin, tied genetically to the risk of vasculitis, modulates monocyte- driven inflammation, and that both may be valuable markers and potential targets of treatment in vasculitis.

PI_NAMEs: FUSSNER, LYNN  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Active Learning;Affect;Alleles;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Alveolar;ANCA vasculitis;Antiinflammatory Effect;Antineutrophil Cytoplasmic Antibodies;Automobile Driving;Basic Science;Benefits and Risks;Binding;biobank;Bioinformatics;Biological;Biological Markers;biomarker driven;biomarker identification;Biometry;career development;CCL2 gene;chemokine;Chemotactic Factors;Clinic;Clinical;clinical center;Clinical Data;clinical phenotype;clinical predictors;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Color;Coupled;Couples;Critical Care;CXCL13 gene;cytokine;Data;Dedications;design;Development Plans;Disease;Disease Marker;disease phenotype;Disease remission;disorder control;disorder risk;Doctor of Philosophy;Environment;Equilibrium;experience;experimental study;FCGR3B gene;Flow Cytometry;Funding;Genotype;Giant Cells;Glomerulonephritis;Goals;Granulomatous;Heart;Hemorrhage;Heterogeneity;IL8 gene;immune function;Immune response;Immunologics;Immunology;Immunosuppression;improved;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;Interleukin-10;Interleukin-6;International;Investigation;Kidney;knock-down;Lesion;Link;Lung;Lung Diseases;lung lesion;Macrophage;Medicine;Membrane;Mentors;Mentorship;Methods;Modeling;monocyte;Morbidity - disease rate;mortality;multidisciplinary;Natural Immunity;neutrophil;next generation;novel;novel therapeutic intervention;Ohio;Pathogenesis;Patient Care;patient oriented;patient population;Patient-Focused Outcomes;Patients;Peptide Hydrolases;personalized management;Phenotype;Physicians;PI3 gene;Play;precision medicine;predictive marker;predictive signature;Production;Proteinase 3;Proteins;Randomized, Controlled Trials;Rare Diseases;receptor;Recurrent disease;Relapse;relapse prediction;Reporting;Research;Research Design;Research Infrastructure;Research Institute;Research Personnel;response;Rheumatology;Risk;Risk Factors;Role;Sampling;Scientist;Serine Protease;skills;Sleep;standard of care;Statistical Models;Surface;systemic autoimmune disease;Testing;Therapeutic;Therapeutic immunosuppression;therapy resistant;Tissues;Training;transcriptome sequencing;transcriptomics;Translational Research;translational research program;treatment risk;treatment strategy;Universities;Vascular Diseases;Vasculitis

PROJECT_TITLE: Novel role of alpha-1 antitrypsin in monocyte-driven disease activity in ANCA-associated vasculitis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The shapes and volumes of cell nuclei vary largely between different cell types and between healthy and diseased cells. To better understand how changes in the nuclear topography between healthy and disease cells can affect gene function requires a standardized nuclear reference coordinate framework to relate the relative nuclear locations of genomic regions between different cells. This proposal develops such a framework and therefore will allow a better understanding of how changes in the nuclear microenvironment of diseased cells can cause detrimental effects in gene function.

PI_NAMEs: KRIEGSTEIN, ARNOLD ;SHEN, YIN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Address;Affect;Benchmarking;Biological;Brain;Cell Nucleus;cell type;Cell Volumes;Cells;Communities;Data;data integration;Data Set;Development;Disease;epigenome;Evaluation;Gene Expression;gene function;Genome;genomic locus;Genomic Segment;Goals;Guidelines;Health;Hi-C;Human;Image;Laboratories;laboratory experiment;Location;Maps;Methods;Multiomic Data;Nuclear;Positioning Attribute;predictive modeling;Productivity;Role;Scientist;Shapes;Source;Standardization;System;targeted imaging;Tissues;Visualization

PROJECT_TITLE: Charting the 3D epigenome in human brain development and diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Black cancer patients experience a greater cancer burden and poorer health outcomes and face more negative social determinants of health (SDH) than their non-Hispanic white counterparts. Adequately assessing patient- reported outcomes (PROs) and SDH in this population may help improve cancer health equity. This study will develop, refine, and implement a PRO/SDH tool tailored to the needs and preferences of Black patients and their cancer care providers.

PI_NAMEs: TARVER, WILLI L (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: acceptability and feasibility;Address;African American;African American population;Attention;Award;barrier to care;Behavioral;Black American;black patient;Black race;Cancer Burden;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;care providers;career;career development;Caring;Characteristics;Clinic;Clinical;clinical decision-making;Clinical Trials;Collection;college;Computer Literacy;Data;Data Collection;Development;digital health;Disparity;Division of Cancer Prevention;Education;Electronics;ethnic minority;experience;Face;feasibility testing;Foundations;Goals;Health;Health behavior;health care disparity;health data;Health Disparities Research;health disparity;health information technology;health record;health related quality of life;Healthcare Systems;improved;interest;Interview;Knowledge;Leadership;Link;low socioeconomic status;Malignant Neoplasms;Manuscripts;Measurement;Measures;Medical;Medicine;Mentors;Minority Groups;minority patient;Not Hispanic or Latino;Ohio;Outcome;Outcome and Process Assessment;Outcome Assessment;Outcome Measure;Patient Care;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;patient-clinician communication;Patients;pilot test;poor health outcome;Population;Poverty;preference;professor;prognostic;programs;Provider;Psychometrics;psychosocial;Public Health Informatics;Qualitative Research;Quality of life;Questionnaires;racial disparity;racial minority;randomized trial;Reporting;Research;Research Methodology;Research Project Grants;Research Training;Scientist;Security;skills;skills training;social;social culture;social health determinants;Sorting;Structure;Technology;Testing;Text Messaging;tool;Training;Underserved Population;Universities;uptake;usability;Writing

PROJECT_TITLE: Improving the Assessment of Patient-reported Outcomes among Black/African-American Cancer Patients


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Alcohol use disorder (AUD) is a substantial and growing problem among older adults, however, care for AUD is underutilized. Improving access to care may have a substantial impact on whether older adults with AUD receive needed care. Findings from the proposed research will generate data-driven insights to inform how payers and health systems can increase uptake of treatment services for AUD and improve AUD-related clinical outcomes.

PI_NAMEs: GLASS, JOSEPH EDWIN;WONG, EDWIN S. (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: addiction;Address;Adopted;Adult;aged;alcohol abuse therapy;alcohol availability;alcohol consequences;Alcohol consumption;alcohol use disorder;Ambulatory Care;Area;Authorization documentation;beneficiary;binge drinking;care coordination;care providers;Caring;Categories;Charge;Clinical;comorbidity;Complex;cost;Cost Sharing;County;Data;design;Development;Diagnosis;Dimensions;disability;Econometric Models;econometrics;economic cost;Eligibility Determination;Enrollment;Ensure;Epidemic;experience;Foundations;Future;General Population;geographic difference;Goals;health care service utilization;Health Personnel;health plan;health service use;Health Services Accessibility;Health system;Healthcare;human old age (65+);Improve Access;improved;Individual;insight;Insurance Carriers;Knowledge;Life;Link;Managed Care;Measurement;Measures;medical specialties;Medicare;Medicare claim;Mental Health;Methods;Modeling;Monitor;mortality;National Institute on Alcohol Abuse and Alcoholism;older adult;Outcome;payment;Pharmaceutical Preparations;Policies;prevent;Primary Care;Privatization;programs;Provider;provider networks;Research;Rural;service providers;Societies;Subgroup;Substance Use Disorder;treatment services;uptake;Variant;Wood material

PROJECT_TITLE: Impacts of Access to Services for Alcohol Use Disorders in Older Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Pancreatic cancer is the third highest cause of cancer-related deaths and about 80% of pancreatic cancer patients suffer from cachexia, which is a debilitating syndrome contributing to increased mortality and decreased efficiency of chemotherapy. We illustrate a common target, Perp, in the tumor and muscles, which when inhibited has the potential to abrogate tumor proliferation and muscle loss upon inhibition. The overarching aim of this study is to elucidate the role of Perp in cancer and cachexia and develop novel inhibitors against Perp.

PI_NAMEs: DASGUPTA, ANEESHA  (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Affinity;Age;age related;aged;Apoptosis;Appetite Stimulants;Atrophic;Binding;Binding Sites;biophysical properties;Cachexia;Cancer Cachexia;Cancer Etiology;cancer invasiveness;Cancer Model;career;Cause of Death;Cell membrane;Cell Proliferation;Cessation of life;Chemoresistance;chemotherapy;Clinic;Clinical Trials;Data;Deposition;Development;Diagnosis;dietary supplements;driver mutation;effective therapy;Event;experience;Fatty acid glycerol esters;FDA approved;Gene Expression;Genes;Genetic;Genetically Engineered Mouse;Goals;Human;improved;in silico;In Vitro;in vivo;inhibitor;Invaded;KRAS2 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;migration;Modeling;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Fibers;Muscular Atrophy;mutant;Mutation;novel;novel therapeutics;old mice;Older Population;Oncogenes;Onset of illness;Operative Surgical Procedures;Outcome;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Paper;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Physiological;PMP22 gene;pre-clinical;Pre-Clinical Model;prevent;Prognosis;Prognostic Factor;Proliferating;Proteins;Proteomics;Publishing;Qualifying;Quality of life;Recovery;Refractory;Reporting;response;Role;Sampling;Signal Pathway;Signal Transduction;skills;small molecule;small molecule inhibitor;Specificity;Survival Rate;Syndrome;Testing;Therapeutic;tool;Toxic effect;TP53 gene;tumor;Tumor Burden;tumor growth;tumor progression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Wholistic Therapies

PROJECT_TITLE: Targeting Perp in PDAC tumor and cancer cachexia


NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE There have been substantial advances in diabetes technologies in recent years, developed in efforts to improve glycemic outcomes and reduce the burdens of diabetes self-management. However, diabetes device use remains particularly low in young adults (YAs) with type 1 diabetes (T1D), an age group that most often reports devices as negatively affecting their self-perception; a timely concern given that identity development occurs in young adulthood. The current study aims to better understand patterns of diabetes technology use and the intersection of technology with identity, in an effort to develop, implement, and evaluate an intervention aimed to enhance diabetes device use within an identity framework, with the ultimate goal of improving the health and psychosocial outcomes of YAs with T1D.

PI_NAMEs: COMMISSARIAT, PERSIS  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Affect;Age;age group;Algorithms;Artificial Endocrine Pancreas;Attention;Award;Behavioral;Body Image;career development;Caring;Characteristics;Child;Chronic Disease;Continuous Glucose Monitor;Data;Dedications;design;Development;Devices;Diabetes Mellitus;diabetes self-management;Dose;Education;Electronic Health Record;Environment;experience;Feedback;Fingers;Focus Groups;Foundations;Fright;Future;Glucose;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Health;Hybrids;improved;Injections;innovation;insight;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;intervention mapping;intervention refinement;Interview;Knowledge;Length;Life;Mentors;Mentorship;Modeling;multidisciplinary;multilevel analysis;Neighborhoods;novel;Outcome;patient oriented;Pattern;Persons;primary outcome;Process;psychosocial;psychosocial outcome;Pump;Randomized, Controlled Trials;recruit;Reporting;Research Personnel;Resources;Risk;Sampling;satisfaction;Self Perception;Series;skills;social health determinants;social influence;Social Network;Social Perception;social stigma;sociodemographic factors;sociodemographics;socioeconomics;standard of care;Statistical Data Interpretation;Structure;Surveys;System;Techniques;Technology;technology intervention;therapy design;therapy development;Time;time use;Training;trend;uptake;Work;young adult

PROJECT_TITLE: Development of an intervention to target diabetes device use through an identity framework: ACCPTech (Adapt and Commit to CGM and Pump Technology)

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE Maternal obesity, the most common medical condition among women of reproductive age, complicates achievement of shared decision-making (SDM) for induction of labor (IOL), which is a standard of informed and person-centered labor and delivery care. The proposed project seeks to shift current research and clinical paradigms for obstetric care among patients with obesity by discovering new evidence for individualized, unbiased IOL counseling. The specific aims will investigate phenotypes of diverse women with obesity in pregnancy, elucidate clinician perspectives on IOL decisional complexity and SDM barriers/facilitators, and engage patients in adapting a PDA for IOL planning with racially and ethnically diverse women with obesity.

PI_NAMEs: GLAZER, KIMBERLY B (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Advancing Shared Decision-Making for Labor Induction among Women with Obesity

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Human papillomavirus (HPV) vaccination is a critical cancer prevention intervention, but adolescents in rural areas of the United States have lower vaccination rates compared to their urban counterparts. We hypothesize that recommending HPV at the earliest possible opportunity (i.e. age 9, as compared to the current standard of 11-12 years) and aligning HPV vaccination with annual well-child visits can increase timely HPV vaccination, particularly in rural areas where receipt of primary care and pediatric care are less convenient and accessible to patients. We propose 1) to develop an acceptable and feasible clinic-based intervention that promotes recommending HPV vaccination to 9-year-old patients; 2) incorporate qualitative insights from caregivers into the intervention plan to minimize caregiver hesitancy; and 3) to pilot this intervention in four rural clinics in North Carolina to assess the hybrid effectiveness-implementation of the intervention under real-world, pragmatic conditions.

PI_NAMEs: VIELOT, NADJA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Developing and piloting an intervention to reduce HPV vaccination disparities in rural adolescents


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

PHR: Public Health Relevance This research project could influence work practices and policies related to handling of potentially hazardous materials in the solid waste stream that could impact the health of the 433,000 US workers employed in the solid waste industry, of which approximately 12% are women and 38% constitute minority groups.

PI_NAMEs: CEBALLOS OCHOA, DIANA MARIA (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Assessing Metals and Flame Retardant Exposures on Solid Waste Workers

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Modifiable risk factors for Alzheimer’s Disease and Related Dementias are more common in racial and ethnic minorities in the United States, who also bear a disproportionate burden of Alzheimer’s Disease. The goal of this proposal is to understand how these modifiable risk factors, which often co-occur, contribute to cognitive disparities during midlife in diverse populations and explore the underlying mechanisms. The findings will provide insights into whether and how modifiable risk factors prevention can benefit efforts to lessen cognitive disparities as early as in midlife, particularly among a growing number of racial and ethnic minorities in the United States.

PI_NAMEs: JIANG, XIAQING  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Adult;Age;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Behavioral;Biological Markers;Biometry;Black race;Blood Vessels;brain health;brain volume;cardiovascular risk factor;Cardiovascular system;Caring;Clinical assessments;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;Communication;Coronary Artery Risk Development in Young Adults Study;cost;cost effective;Data;data harmonization;Data Pooling;design;Diabetes Mellitus;disability;Disease;Disparity;Dyslipidemias;Early identification;Education;Epidemiology;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;Funding;Goals;Health;health disparity;hearing impairment;high risk;high risk population;Hispanic;Hypertension;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Joints;late life;Life;Life Cycle Stages;lifestyle factors;Link;Longitudinal cohort;Longitudinal cohort study;Machine Learning;Measurement;Measures;Mediating;Mental Depression;Mentorship;Methods;Microvascular Dysfunction;middle age;modifiable risk;Modification;multidisciplinary;Nerve Degeneration;Obesity;Pathway interactions;Pattern;Phase;physical inactivity;population based;Population Heterogeneity;Prevention;programs;prospective;Psychometrics;psychosocial;Psychosocial Factor;public health priorities;Race;racial difference;racial disparity;racial minority;racial population;Registries;Research;research clinical testing;Research Personnel;response;Risk;Risk Factors;risk prediction model;Risk Reduction;Role;skills;Smoking;social factors;Social isolation;structural determinants;Subgroup;tau Proteins;Techniques;Testing;theories;therapeutic target;Time;Training;Training Activity;Traumatic Brain Injury;United States;United States National Institutes of Health;Vascular Diseases;Wisconsin;Work

PROJECT_TITLE: Modifiable risk factors and midlife cognition in diverse populations: a pooled cohort study

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE After injury, zymogenic cells of the gastrointestinal tract (e.g., pancreatic acinar and gastric chief cells) can become metaplastic, and then be recruited back into the cell cycle for regeneration of lost cells through a potentially carcinogenic process known as paligenosis. Zymogenic cells devote the vast majority of energy and resources to biogenesis and maintenance of ribosomes, which are critical for translation. This study aims to deﬁne the role of ribosome generation and regulation in the context of injury, tissue regeneration, paligenosis and carcinogenesis, which are a signiﬁcant burden on human health.

PI_NAMEs: CHO, CHARLES J (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acinar Cell;Address;Advisory Committees;Anabolism;Attention;Autophagosome;Back;Binding Proteins;Biogenesis;Board Certification;carcinogenesis;carcinogenicity;Career Choice;career development;Catabolism;Cell Culture Techniques;Cell Cycle;Cell Differentiation process;Cell division;Cell Fractionation;cell growth;cell injury;Cell model;Cell Physiology;Cells;Cellular biology;Chief Cell;Chronic;chronic pancreatitis;Clinical;college;conditional knockout;Confocal Microscopy;Core Facility;Cryo-electron tomography;Decision Making;Dedications;Development Plans;Digestive System Disorders;DNA Damage;Doctor of Medicine;Doctor of Philosophy;Drops;Duct (organ) structure;Elements;Endoplasmic Reticulum;Environment;Enzymes;experience;Foundations;Funding;Gastric Chief Cells;gastric corpus;Gastroenterologist;Gastroenterology;Gastrointestinal Diseases;Gastrointestinal Endoscopy;Gastrointestinal tract structure;gene induction;Generations;Goals;Growth;Health;Helicobacter pylori;Hepatology;Histology;Human;in vivo;Infection;Inflammation;inhibitor;Injury;insight;instructor;International;Knockout Mice;Knowledge;Laboratories;Laboratory Animal Production and Facilities;Licensing;Maintenance;Malignant Neoplasms;Mediating;Medical center;Medical Research;Medicine;meetings;member;Mentorship;Metaplasia;Methodology;Mitosis;Mitotic;Molecular;Morphology;Mus;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Organelles;paligenosis;Pancreas;pancreatic tumorigenesis;Pathway interactions;Peptides;Persons;Phase;Play;Positioning Attribute;preservation;Principal Investigator;Privatization;Procedures;Process;Production;progenitor;programs;Proliferating;Proteins;recruit;Regulation;repaired;Research;research and development;Research Project Grants;Resources;response;response to injury;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RiboTag;Role;Rough endoplasmic reticulum;S phase;Secretory Cell;Secretory Vesicles;Series;Sirolimus;South Korea;Spasmolytics;stem cell genes;stem-like cell;Stress;System;Testing;Texas;Time;tissue regeneration;tool;TP53 gene;Training;Transcript;transcriptome;Translating;Translation Process;Translations;tumorigenesis;Visit;Work

PROJECT_TITLE: THE ROLE OF RIBOSOMES IN METAPLASIA IN THE GASTROINTESTINAL TRACT

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Latinx young adults are acutely vulnerable to alcohol-related health disparities, and even more worrisome, this population demonstrates extremely low engagement rates in alcohol use disorder recovery support. Hence there is a critical need for the development of scalable, culturally appropriate, accessible, and effective alcohol interventions for this large and rapidly growing at-risk population. This study aims to address this need by socio- culturally adapting an existing underutilized evidence-based intervention and making it broadly available through a smartphone app.

PI_NAMEs: HAI, HANG  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acculturation;Achievement;Acute;Address;age group;Alcohol abuse;alcohol abuse therapy;alcohol intervention;alcohol misuse;alcohol use disorder;alcohol-related injury;Alcoholics Anonymous;Alcohols;Area;Award;barrier to care;Behavior Therapy;career;Cellular Phone;community advisory board;Control Groups;cost;cost effective;Data;design;Development;Dimensions;Disadvantaged;Disparity;drinking;Effectiveness;eHealth;Enhancement Technology;Ensure;ethnic discrimination;evidence base;Evidence based intervention;experience;Feedback;Fellowship;Focus Groups;Future;Goals;Group Interviews;handheld mobile device;hands on research;health disparity;health inequalities;Health Resources;Health Technology;High Prevalence;Immigrant;improve minority health;improved;Inequity;innovation;Insurance;International;Intervention;Journals;Knowledge;Language;Latinx;Latinx population;Lifting;Link;Literature;Liver diseases;Manuals;marginalization;marginalized population;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;mHealth;Minority;Minority Groups;Minority Status;Modeling;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Ownership;Pamphlets;people of color;Persons;Population;Populations at Risk;Prevalence;programs;Public Health;Publications;Qualitative Research;Randomized;randomized trial;Recovery;Recovery Support;Recurrence;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;response;Role;Sampling;skills;smartphone application;social;social culture;social stigma;Spirituality;Strategic Planning;Stress;substance use;support network;Technology;Testing;therapy development;Time;tool;Training;Underserved Population;United States;United States National Institutes of Health;Update;Wait Time;women of color;Work;young adult

PROJECT_TITLE: Culturally Adapting Spiritually and Technologically Informed Interventions to Reduce Alcohol-Related Health Disparities among Latinx Young Adults

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Frontotemporal dementia (FTD) is a rare form of dementia associated with Alzheimer’s disease and related dementias (AD/ADRD) that affects thousands of individuals in the US and for which there is no cure. Drug discovery is extremely important to develop effective drugs for the treatment of FTD and other neurodegenerative diseases, but it is a highly costly and time-consuming process. An alternative strategy is the re-purpose of FDA approved drugs to expedite the development of therapeutic strategies to treat memory loss and improve the quality of life of patients with FTD.

PI_NAMEs: GOMEZ-PASTOR, ROCIO  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Affect;Alleles;Alzheimer's disease related dementia;Antineoplastic Agents;Area;Behavior;Behavioral;Biological Availability;Brain;brain control;calmodulin-dependent protein kinase II;casein kinase II;Catalytic Domain;Cell Death;Cell Physiology;Clinical Treatment;Clinical Trials;Cognition;Confusion;Consumption;cost;Data;Dementia;Disease Progression;drug discovery;Emotions;excitatory neuron;Foundations;frontal lobe;Frontotemporal Dementia;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Glutamates;Holoenzymes;Human;Huntington Disease;Image;improved;Individual;Inflammation;Inherited;inhibitor;Learning;Malignant Neoplasms;Memory;Memory impairment;Memory Loss;Moods;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;Oral;Pathologic;Pathology;Patients;Penetration;Personality;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphorylation;preclinical study;Process;promoter;protein aggregation;protein misfolding;Protein-Serine-Threonine Kinases;Proteins;Proxy;Quality of life;Research;Role;sensor;Short-Term Memory;Signal Transduction;Solubility;symptomatology;Synapses;synaptic function;tau aggregation;tau mutation;tau Proteins;tau-1;Temporal Lobe;Therapeutic;therapeutic development;Time;transcriptome sequencing;treatment strategy;United States Food and Drug Administration;Western Blotting

PROJECT_TITLE: Assessment of the therapeutic potential of the anticancer agent Silmitasertib in the treatment of memory loss in Frontotemporal dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunization;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The proposed research is relevant to the NIH mission to seek fundamental understanding of mechanisms driving head and neck cancer to enhance health, lengthen life and reduce illness in these patients. Immunotherapy is a new method of cancer treatment that recruits the immune system to help target and kill cancer cells, and it was recently FDA approved for patients with recurrent or metastatic head and neck cancer, however less than 20% of these patients will respond to treatment. To improve response rates, we propose to identify novel neoantigens through interrogation of splicing alterations in oral cancer that represent potential vaccine targets to boost the immune system and enhance response to immunotherapy.

PI_NAMEs: GUO, THERESA  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Affinity;Algorithms;Alternative Splicing;anti-PD1 therapy;Antigen Targeting;Antigens;Automobile Driving;Binding;biobank;Biological Assay;Blood specimen;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Cancer Vaccines;candidate identification;career;Cells;checkpoint therapy;Clinic;Clinical Trials;Combined Modality Therapy;computational pipelines;Computing Methodologies;design;Detection;DNA Sequence Alteration;Event;FDA approved;Foundations;Future;Goals;Head and Neck Cancer;Head and Neck Neoplasms;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health;High Prevalence;HPV positive;HPV-negative head and neck cancer;Human;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunocompetent;immunogenic;immunogenicity;Immunologic Stimulation;Immunologics;Immunotherapy;improved;Life;Literature;malignant mouth neoplasm;Malignant Neoplasms;Measures;Metastatic/Recurrent;Methods;Mission;mouse model;Mus;Mutation;neoantigens;new therapeutic target;Newly Diagnosed;novel;Oncology;Patients;Peptides;personalized immunotherapy;Point Mutation;Population;predicting response;Prediction of Response to Therapy;Proteins;Publishing;recruit;Recurrence;Regulation;Research;response;RNA Splicing;Role;Solid Neoplasm;Somatic Mutation;Source;T cell response;T cell therapy;targeted biomarker;therapeutic target;translational applications;Translations;treatment strategy;tumor;tumor growth;Tumor Immunity;Tumor-Derived;United States National Institutes of Health;Vaccinated;Vaccination;vaccine development;Vaccine Therapy;Vaccines;Variant;Work

PROJECT_TITLE: Identification of splice variant derived neo-antigens in head and neck squamous cell carcinoma as targets for tumor vaccine therapy

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine

PHR: NARRATIVE Loss-of-function alterations in STK11 have been shown to confer poor prognosis and resistance to immune checkpoint blockade (ICB) in NSCLC through incompletely understood mechanisms of tumor intrinsic resistance and immunosuppressive features of the tumor microenvironment (TME). Here, we propose investigation of tumor differentiation phenotypes as a key determinant of immune resistance, and parallel evaluation of TRAF2/cIAP1 as a critical and targetable resistance mechanism that appears to be influenced by differentiation state. Our work will combine in vitro mechanistic studies, in vivo and patient level studies of TME and ICB response, and development of differentiation-based biomarker that can accurately detect these phenotypes in clinical samples. Our results will establish TRAF2/cIAP1 inhibition as a promising target to enhance immunotherapy response in STK11-deficient lung cancer, alongside a paired biomarker that may guide the clinical use of this approach, thus representing a novel precision IO paradigm.

PI_NAMEs: KAUFMAN, JACOB MARCUS (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;Affect;anti-PD-1;Area;assay development;Bioinformatics;Biological;Biological Markers;Biological Response Modifiers;biomarker driven;Biometry;career;career development;Cell Death;Cell Line;Cells;Clinical;clinical predictors;clinically actionable;Coculture Techniques;cohort;Complement;Credentialing;cytotoxicity;Data;Dendritic Cells;Dependence;Development;Development Plans;Evaluation;Event;experimental study;Flow Cytometry;Foundations;Future;Gene Expression;genetic approach;Genomics;Goals;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;immune resistance;Immune response;Immunooncology;Immunotherapy;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;insight;Investigation;Knowledge;Leadership;Link;Liver;loss of function;loss of function mutation;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;MAP3K7 gene;Measures;Mediating;Mentorship;multiple omics;Mus;Mutate;Neoadjuvant Therapy;neuroendocrine differentiation;NF-kappa B;Non-Small-Cell Lung Carcinoma;novel;novel marker;Outcome;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;personalized approach;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Physicians;Population;Precision therapeutics;predictive marker;Prognosis;programmed cell death protein 1;promoter;recruit;Regulation;Research Personnel;Resistance;resistance mechanism;response;RIPK1 gene;RIPK3 gene;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;Source;Specificity;STK11 gene;success;T-Lymphocyte;Therapeutic;Thoracic Oncology;TNF gene;tool;TRAF2 gene;transcriptome sequencing;treatment and outcome;Treatment outcome;treatment strategy;tumor;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;Work

PROJECT_TITLE: Biomarker-Driven Strategies to Overcome Immunotherapy Resistance in STK11-Deficient NSCLC


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The control of virulence two-component gene regulatory system (CovRS) is central to the ability of group A Streptococcus (GAS) to cause serious human infections. Although CovR is generally thought to be a gene repressor, we have recently discovered that CovR also directly activates the expression of a diverse array of genes. The purpose of this investigation is to delineate mechanisms by which CovR activates gene expression including the gene encoding the critical GAS virulence factor streptokinase.

PI_NAMEs: SHELBURNE, SAMUEL A (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: active control;Address;Affinity;anti-microbial drug;antimicrobial;Bacteria;Bacterial Genes;Binding;Binding Sites;Biological Assay;Biological Models;ChIP-seq;comparative;Coronavirus;Data;defined contribution;Development;Digestion;DNA;DNA Binding;environmental change;Exonuclease;experimental study;extracellular;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Goals;Gram-Positive Bacteria;Homologous Gene;Human;human pathogen;improved;In Vitro;in vivo;Infection;insight;Investigation;Knowledge;Laboratories;Learning;Location;luminescence;Mediating;Medical;member;Membrane;Modeling;Molecular;novel;Operon;Pathogenesis;Pattern;Phosphorylation;Phosphotransferases;Plasmids;Production;promoter;Protein Dephosphorylation;Protein Isoforms;protein-histidine kinase;Reaction;Reporter;Repression;Research;Resolution;response;RNA;Role;sensor;Staphylococcus aureus;Stimulus;Streptococcus;Streptococcus pyogenes;Streptokinase;System;Testing;TPD52L1 gene;Transcript;Transcription Repressor;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Delineation of mechanisms underlying response regulator activation in group A Streptococcus

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Multiple sclerosis (MS) is an autoimmune neurological disease affecting nearly 1 million people in the United States and is the most common cause of nontraumatic disability in young adults. MS is highly associated to Epstein-Barr virus (EBV), but the mechanisms underlying MS are poorly understood. Success of the proposed studies would explain the role of EBV in the pathophysiology of MS using large patient cohorts which could lead to transformative and fundamental treatment approaches focused on preventing or treating EBV rather than non- specifically depleting B cells or inhibiting immune cell trafficking.

PI_NAMEs: SATTARNEZHAD OSKOUEI, NEDA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immunity;Address;Affect;Aftercare;Antibodies;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Diseases of the Nervous System;Autoimmunity;Axon;B-Lymphocytes;Biological Assay;Biological Markers;career;career development;Cell Adhesion;Cell Adhesion Molecules;Cells;Chronic disability;Clinical;cohort;Cross Reactions;Cytomegalovirus;Data;Development;Development Plans;disability;Disease;Disease Progression;Disease remission;disorder control;Dysplasia;EBV-encoded nuclear antigen 1;Epidemiology;Epstein-Barr Virus Infections;Exclusion Criteria;Flare;Functional disorder;Genetic;Goals;Heat shock proteins;Human;Human Herpesvirus 4;Image;Immune;immunogenicity;Individual;Infection;Informatics;insight;Magnetic Resonance Imaging;Measures;Mentored Patient-Oriented Research Career Development Award;Molecular Mimicry;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Neoplasms;Nerve Degeneration;Neuroimmune;neuroimmunology;Neurologic;Neurons;Nuclear Antigens;Oligodendroglia;Onset of illness;patient subsets;Patients;Persons;Phase;Population;Prevalence;prevent;Proteomics;Relapse;Research;Research Project Grants;Role;Sampling;Scientist;Serum;single molecule;skills;Subgroup;success;targeted treatment;Technology;Testing;Time;timeline;trafficking;Training;Training and Education;transcription factor;treatment response;United States;Viral;Viral Antigens;Viral Load result;Viral Proteins;young adult;α-Crystallins

PROJECT_TITLE: Defining the Role of Epstein-Barr Virus in Multiple Sclerosis

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.

PI_NAMEs: PALATNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: 2 arm randomized control trial;Acceleration;active control group;Address;Affect;Angiogenesis Inhibitors;Angiogenic Proteins;arterial stiffness;Biological Markers;Birth;black patient;Blood;Blood Pressure;blood pressure control;Blood Pressure Monitors;Blood Vessels;brachial artery;Brain hemorrhage;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cessation of life;Childbirth;Chronic;clinical practice;comparison control;Diagnosis;endothelial dysfunction;Endothelium;Ensure;Event;Face;Femur;Future;Goals;group intervention;Heart failure;Hypertension;hypertensive;improved;Individual;innovation;Knowledge;Level of Evidence;Measures;Mediating;Newly Diagnosed;Nifedipine;Not Hispanic or Latino;novel;Participant;Patients;Perinatal;Pharmaceutical Preparations;Physiologic pulse;Populations at Risk;post pregnancy;postpartum complications;Postpartum Hypertension;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;primary outcome;Protocols documentation;Public Health;racial disparity;Randomized;Randomized, Controlled Trials;Recovery;response;Risk;Risk Reduction;Sampling;secondary outcome;Serum;Site;Standardization;telemonitoring;Testing;Time;Translating;treatment as usual;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;vascular inflammation;vascular injury;Vascular remodeling;vasoconstriction;Work

PROJECT_TITLE: Reducing the risk of chronic hypertension and improving vascular function following preeclampsia

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE - Parent A major barrier to decoding the human genome is a lack of maps, models and tools to understand how transcriptional control sequences are spatially and temporally organized in the nucleus to regulate gene expression. The proposed research will address this pressing need by deploying transformative technologies to produce navigable reference maps and predictive structural models for diverse cell types in the mammalian brain. The results could facilitate the functional annotation of the human genome and improve our understanding of the genetic basis of a variety of neurological diseases.

PI_NAMEs: DULAC, CATHERINE ;LEIN, ED ;NICODEMI, MARIO ;POMBO, ANA ;REN, BING  (contact);WANG, TING ;ZHUANG, XIAOWEI

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Address;Administrative Supplement;Adult;analytical tool;Architecture;ATAC-seq;Atlases;Benchmarking;Biological;Brain;BRAIN initiative;Cardiac Myocytes;Cell Differentiation process;Cell Line;Cell model;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Modeling;Chromatin Structure;Communication;Communities;Companions;Complex;Computer Analysis;Computer software;computerized tools;Computing Methodologies;congenital heart abnormality;Data;data integration;Data Set;Development;Disease;DNA mapping;DNA methylation profiling;embryonic stem cell;Enhancers;Experimental Models;experimental study;Foundations;Funding;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Human;human disease;Human Genome;human induced pluripotent stem cells;Image;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;learning strategy;Macaca;Mammalian Cell;Maps;Measures;method development;Methods;Methylation;methylome;Modality;Modeling;Molecular;multimodality;Mus;nerve stem cell;Nervous System Disorder;neural;Neurologic;Neurons;Nuclear;parent grant;Parents;Pathogenesis;Phase;Physics;Physiological;Pilot Projects;Polymers;Population;Process;programs;promoter;Readiness;Research;Research Activity;Research Project Grants;Resolution;Role;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Slice;Software Tools;statistical learning;Structural Models;Structure;System;Technology;three dimensional structure;Time;Tissues;tool;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;Validation;Visualization;working group

PROJECT_TITLE: Center for Integrated Multi-modal and Multi-scale Nucleome Research


ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE: From ancient to modern times fasting has been recognized as an effective way to improve health, slow down aging, and reduce the risk of many aging-related pathologies, such as insulin resistance; yet it is unclear how fasting establishes those benefits at molecular levels. My data provide evidence for the existence of a novel gene expression network that regulates metabolic reprogramming upon fasting; however, this pathway is blunted during aging, and disruption of this pathway may lead to aging related insulin resistance. Characterizing this novel pathway will lead to the identification of new therapeutic targets for aging related insulin resistance and type 2 diabetes.

PI_NAMEs: YANG, HAOJUN  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 5' Untranslated Regions;Acids;Advisory Committees;Affect;age related;Aging;aging related;aging related disease;Animals;anti aging;Binding;Biological Assay;Blood;Cell Aging;Cell model;Cell Physiology;collaborative environment;Coupled;Data;detection of nutrient;Development;Diabetes Mellitus;Diet;Disease;Down-Regulation;Environment;Event;Exhibits;Fasting;Fatty Acids;FRAP1 gene;Gene Expression;Genes;gerotherapeutic;glucose metabolism;Greek;Health;Health Benefit;healthspan;Hepatocyte;Human;Impairment;improved;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;ketogenesis;ketogenic diet;Ketone Bodies;Ketones;Label;Link;lipid metabolism;Liver;Longevity;MAP Kinase Gene;Mass Spectrum Analysis;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic syndrome;metabolomics;middle age;Mitogen-Activated Protein Kinase Kinases;Modernization;Molecular;mouse model;mRNA Translation;multidisciplinary;Mus;Mutagenesis;Mutant Strains Mice;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Nutrient;old mice;Pathology;Pathway interactions;Phosphorylation;Physiological;prevent;Process;Production;programs;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Proteins;Proteome;receptor;Recommendation;Reporting;Research;response;Risk;Risk Reduction;RNA Cap-Binding Proteins;Role;Serine;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;System;transcriptomics;translation factor;Translations;translatome;upstream kinase;Work

PROJECT_TITLE: Fatty acid remodeling of the translatome during fasting and aging


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOLOGY

PHR: Project Narrative The endoplasmic reticulum (ER) is one of the largest cellular organelles and carries out essential functions, producing almost all membrane proteins, secretory proteins, and lipids of the cell. We uncovered a regulatory pathway termed the ER Surveillance Pathway or ERSU that operates to ensure dividing cells will inherit only functionally competent ER. Dissection of the ERSU pathway and its underlying molecular machinery will contribute to understanding how cells may bypass such quality control checkpoints and contribute to the pathogenesis of cancers and other proliferative disorders.

PI_NAMEs: NIWA, MAHO R (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Anabolism;Binding;Biological;Bypass;Cell Cycle;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell surface;Cells;Cytokinesis;daughter cell;Disease;Dissection;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Event;event cycle;Exclusion;Failure;Genome;Homeostasis;human disease;Inherited;insight;Lipids;Malignant Neoplasms;Mammalian Cell;Membrane Proteins;Mitosis;Mitotic;Mitotic Cell Cycle;model organism;Molecular;Morphology;Motion;Neck;Nuclear;Nuclear Envelope;Organelles;Pathogenesis;Pathway interactions;phytosphingosine;Protein Family;Proteins;Quality Control;Regulation;Regulatory Pathway;response;Role;Saccharomyces cerevisiae;secretory protein;Site;Sphingolipids;Stress;Transmembrane Domain;Yeasts

PROJECT_TITLE: Roles of the ER Stress Surveillance Pathway During the Cell Cycle

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Digestive Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Parkinson’s Disease may begin in the gut. This research will determine how damage to mitochondria in the intestine can contribute to the spread of Parkinson’s Disease pathology (α-Synuclein) from the gut to the brain. Findings from this research may lead to new ways to diagnose Parkinson’s Disease earlier, as well as new ways to treat both damage to neurons in the brain and gastrointestinal symptoms through therapies directed at the gut.

PI_NAMEs: VIDELOCK, ELIZABETH JANE (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Adult;aged;Aging;alpha synuclein;Animal Model;Basic Science;biobehavior;biological adaptation to stress;Board Certification;Brain;career development;Cells;Central Nervous System;Chronic;Clinical Sciences;Colitis;Corpus striatum structure;Coupled;cytokine;Data;design;Development Plans;Diagnosis;Disease;disease model;disease phenotype;Disease Progression;Dopamine;Duodenum;early detection biomarkers;Early Diagnosis;Enteral;Enteric Nervous System;Epithelial Cells;Epithelium;Event;Excision;experience;Exposure to;Extracellular Space;Gastroenterologist;gastrointestinal epithelium;gastrointestinal symptom;Gastrointestinal tract structure;Goals;gut inflammation;gut-brain axis;Health;Homeostasis;Human;Immune;Impairment;Inflammation;Inflammatory;Inflammatory Response;Injections;Institution;intestinal epithelium;Intestines;juvenile animal;Knockout Mice;Knowledge;Leadership;Measurement;Measures;Mediating;Mentors;Mentorship;Metabolism;Midbrain structure;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;Motility;Motor;motor deficit;Mus;Neurodegenerative Disorders;Neurons;neurotransmission;older adult;Organoids;overexpression;Parkin;Parkinson Disease;Pathogenicity;Pathologic;Pathology;Phase;pre-formed fibril;preservation;professor;programs;Proliferating;Psychiatry;Publishing;Research;response;Risk;Risk Factors;Rodent;Rodent Model;Role;Science;Series;Signal Transduction;skills;Stress;systemic inflammatory response;Testing;theories;Tissues;Toll-like receptors;tool;Training;Vagotomy;Vagus nerve structure;Wild Type Mouse

PROJECT_TITLE: Intestinal mitochondrial dysfunction and the gut-brain-immune axis in models of Parkinson's Disease


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This application is a resubmission in response to the Funding Opportunity Announcement (FOA) identified as PAR-21-271. PROJECT NARRATIVE  American Indians/Alaskan Natives (AIANs) experience significant health disparities for cancer, which are driven by both biological determinants, such as Indigenous American genetic ancestry, and social determinants of health, such as socioeconomic status and geographical distance from care facilities. This proposal aims to understand these drivers through the engagement of Native communities living within the UC Davis Comprehensive Cancer Center catchment area. The results of this proposal will provide critical knowledge for the development of more effective treatments and interventions to improve cancer health among AIANs while also creating the infrastructure to ethically engage Native communities for participation in cancer research.

PI_NAMEs: HALMAI, NICOLE BRITNEY (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Admixture;Affect;Alaska Native;American Indians;anti-cancer research;Area;Automobile Driving;Back;Biological;Biomedical Research;California;cancer care;cancer diagnosis;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;cancer type;Catchment Area;Clinic;Clinical Trials;cohort;Communities;community advisory board;community based participatory research;community collaboration;community engagement;Community Health;community intervention;community living;Community Participation;community-centered;comorbidity;Comprehensive Cancer Center;Data;data registry;Data Set;Decision Making;Development;Diagnosis;Diffuse;Disparity;effective intervention;effective therapy;Elements;Ensure;Ethics;ethnic minority;Ethnic Population;exome sequencing;experience;Focus Groups;follow-up;Funding Opportunities;Genes;Genetic;Genome Stability;Geography;Group Interviews;Guidelines;Haplotypes;Health;health assessment;Health behavior;Health Benefit;health care availability;Health care facility;health equity;Health Priorities;Health Services Accessibility;Hispanic;improved;Incidence;Indigenous;Indigenous American;indigenous community;Individual;Infrastructure;Intervention;Knowledge;Latino;Malignant Neoplasms;malignant stomach neoplasm;member;minority communities;minority health;minority health disparity;Mission;Modeling;Molecular;mortality;National Institute on Minority Health and Health Disparities;Needs Assessment;neoplasm registry;North America;novel;Organoids;Outcome;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Pilot Projects;Population;pre-clinical;precision medicine;precision oncology;prevent;Prevention;Process;Race;racial minority;racial population;recruit;Reduce health disparities;Reporting;Research;Research Design;Resistance;response;Risk Behaviors;Sampling;social determinants;Social Environment;social health determinants;sociodemographics;Socioeconomic Status;socioeconomics;success;Surveys;Survival Rate;The Cancer Genome Atlas;Therapeutic;therapeutic development;Time;Translating;Translations;trend;tribal Nation;Trust;tumor;Voice;willingness;Work

PROJECT_TITLE: Advancing Indigenous Cancer Health Equity through a Community-Centered Framework

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

PHR: Project Narrative  Over 43 million Americans (~13% of the population) will suffer from social anxiety disorder at some point in their lives (Kessler, et al., 2012), but a leading form of treatment (cognitive-behavioral therapy, a major component of which is exposure therapy) is only fully effective in approximately 45% of individuals (Loerinc, et al., 2015). Critically, based on robust basic scientific research in the animal and human literatures, there is strong reason to believe that improving reward processing will enhance i) relief-pleasantness when an expected aversive outcome does not occur, ii) Pavlovian extinction of fear, and iii) exposure therapy outcome. In this K23, we will investigate the effects of Positive Affect Treatment (designed to increase reward processing) vs Relaxation Treatment (control condition) on subsequent exposure therapy outcome (fear of public speaking) for socially anxious individuals who have a fear of public speaking and low reward processing while measuring the treatment mechanism (reward processing) before, during, and after treatment.

PI_NAMEs: ZBOZINEK, TOMISLAV DAMIR (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Aftercare;American;Anhedonia;Animals;Anxiety;anxious individuals;Basic Science;Behavior Therapy;Behavioral;Brain;career;Clinical;Cognitive Therapy;Computer Models;conditioned fear;Corpus striatum structure;design;Dopamine;Event;experience;Extinction;Food;Fright;Functional Magnetic Resonance Imaging;Goals;Hobbies;Human;improved;indexing;Individual;insight;Investigational Therapies;Judgment;learning extinction;Link;Literature;Measures;Mediating;Methods;multimodality;National Institute of Mental Health;negative affect;neural;neuromechanism;novel;Outcome;Participant;Patient Self-Report;Persons;Population;Prevention;primary outcome;Proxy;psychologic;Public Speaking;Randomized;Randomized, Controlled Trials;recruit;Relaxation;Research;reward circuitry;reward processing;Rewards;Scientist;Services;Shock;skills;social;social anxiety;Social Anxiety Disorder;social situation;Speech;Strategic Planning;success;Therapeutic Studies;therapy outcome;Time;Training;Translational Research;treatment of anxiety disorders;Treatment outcome;Work

PROJECT_TITLE: Reward Processing and Exposure Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (01)]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research;Sleep Research

PHR: PROJECT NARRATIVE Migraines are common, affecting 1 out of 5 Americans, and lead to significant disability. This research studies the interaction between sleep and migraine. The goal of this research is to identify new therapeutic targets to treat and lessen the burden of migraine.

PI_NAMEs: NWAOBI, SINIFUNANYA ELVEE (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Acute;Adenosine;Adult;Affect;American;Animals;antagonist;Astrocytes;Biology;Blood Vessels;Brain;career;career development;Cells;Characteristics;Childhood;Chronic;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical Data;clinically relevant;Common Migraine;Coupled;Data;Data Sources;Dedications;Development;Development Plans;disability;Disabling;Disease;Diurnal Rhythm;Drug Targeting;Drug usage;Electrophysiology (science);Ensure;Environment;Exhibits;experience;Exposure to;Failure;Fiber;Fostering;Foundations;Frequencies;Functional disorder;Funding;Future;G-Protein-Coupled Receptors;Goals;Headache;High Performance Computing;Hour;Hypothalamic structure;in vivo;in vivo monitoring;innovation;insight;Jet Lag Syndrome;Kinetics;Knowledge;Laboratories;lens;Light;Literature;Marketing;Mediating;Mediator;Medicine;Mentors;Mentorship;microelectronics;Migraine;migraine treatment;minimally invasive;Modeling;Molecular;Neurologist;Neurons;Neurosciences;new technology;new therapeutic target;Nitroglycerin;non rapid eye movement;novel;novel therapeutic intervention;Pain;Pain Research;Patient Care;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Physiological;Physiology;Polysomnography;preclinical study;Predisposition;preoptic nucleus;pressure;Process;programs;Purinergic P1 Receptors;receptor;Research;research and development;Research Proposals;research study;response;Rodent Model;Role;Scientist;sensor;Signal Transduction;skills;Sleep;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep physiology;Sleep Wake Cycle;Spreading Cortical Depression;Statistical Data Interpretation;Structure;targeted treatment;Techniques;translational impact;translational potential;Translational Research;Traumatic Brain Injury;Work

PROJECT_TITLE: Adenosine Modulation of the Bi-Directional Relationship between Sleep and Migraine

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE  The 4D Nucleome (4DN) Initiative aims to address important questions concerning the molecular and biophysical mechanisms involved in chromosome folding, the functions of specific proteins and RNAs, and the relationship between chromosome folding and gene expression. The goal of this proposal is to leverage the successful collaboration between multiple funded laboratories working in the 4DN Imaging Working Group (IWG) and the 4DN Data Coordination and Integration Center (DCIC) to build standard data types and automated pipelines for handling data arising from multiplexed FISH/FISH Omics imaging experiments. These tools will be designed to promote the generation of high-quality, well- documented, reproducible, and reusable datasets, and foster the development of shared downstream processing pipelines for visualization and predictive modeling by the 4DN research program and the community at large.

PI_NAMEs: FOLTZ, DANIEL RICHARD;HUANG, SUI ;KAUFMAN, PAUL D. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Benchmarking;bioimaging;Biophysical Process;Chromatin;chromosome conformation capture;Chromosomes;Collaborations;Communities;Data;data exchange;data format;data ingestion;data portal;data reuse;Data Set;data sharing;data standards;data submission;Deposition;design;Detection;Development;DNA;experimental study;Fostering;Funding;Gene Expression;General Population;Generations;genome browser;genomic locus;Goals;Image;image archival system;Imaging Techniques;improved;Laboratories;machine learning classification;Manuals;Maps;Metadata;Modeling;Molecular;nanoscale;Nuclear;Oligonucleotides;particle;physical mapping;predictive modeling;Procedures;Process;Production;Productivity;programs;Proteins;prototype;public repository;Quality Control;Recommendation;Reproducibility;Research;RNA;Scientist;Software Tools;Specific qualifier value;Spottings;Standardization;Technology;tool;tool development;Visualization;working group

PROJECT_TITLE: Pipelines for Multiplexed FISH Chromatin Tracing data deposition, quality control, and sharing through the 4DN-Data Portal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The proposed work will partner in the development of Alzheimer’s disease and related dementia (ADRD) research capacity at Universidad Javeriana in Bogotá, Colombia. We will fortify a new Doctorate of Neurosciences program, expand networking opportunities across the country, strengthen the early career mentoring team, and fortify research relationships with universities in Colombia and the U.S.

PI_NAMEs: MATALLANA, DIANA ;SANTAMARIA-GARCIA, HERNANDO ;VALCOUR, VICTOR  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;brain health;career;Caring;Collaborations;Colombia;Country;Data;Dementia;Development;early onset;Education;Educational workshop;Equity;experience;Faculty;Fortification;Funding;Grant;Inherited;Latin America;Leadership;low and middle-income countries;Mentors;National Institute on Aging;Neurosciences;patient oriented;programs;Research;Research Project Grants;Research Support;Research Training;Resources;response;skills;statistics;Students;success;Time;Training;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Research Training for Equity in Alzheimer's Disease and Brain Health in Colombia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (50)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE A substantial proportion of the growing elderly population have Alzheimer's disease or related dementias (ADRD), and their progressive daily challenges to meeting essential needs (e.g., managing finances, medication, transportation) are exacerbated when they live alone and thus lack cohabitants who can compensate for the cognitive impairment, leading to emergent problems including untreated medical conditions, self-neglect, malnutrition, falls, and fires. To help address this large and growing problem, the proposed research will elucidate key barriers and facilitators to accessing and using long-term services and supports (LTSS) for older adults with ADRD, especially those who live alone and racial/ethnic minorities. The results of this study will support policies to increase access, affordability, acceptance, and use of essential LTSS for these vulnerable populations. 1

PI_NAMEs: PORTACOLONE, ELENA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Administrator;Adult Children;Affect;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian population;Black Populations;care systems;Child;Cognition;cohort;Communities;community advisory board;community living;Compensation;Consultations;cost;Data;design;Development;development policy;disability;Distress;Education;Elderly;Ensure;ethnic minority;Ethnic Origin;Ethnic Population;falls;Family;Family member;family support;Fire - disasters;Friends;Future;Health;Health and Retirement Study;health disparity;Health Services Accessibility;Heterogeneity;high risk;Home Health Aides;Hospitalization;human old age (65+);Impaired cognition;Individual;informant;Institutionalization;Interview;Knowledge;Latino Population;Link;Lived experience;Living Arrangement;Malnutrition;Medicaid;Medical;meetings;Methods;Modeling;older adult;Older Population;Outcome;participant observation;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;policy recommendation;Population;Positioning Attribute;Provider;Public Health;Race;racial minority;racial population;Reduce health disparities;Reporting;Research;Rural;Self Care;self neglect;Services;Social Workers;Spouses;Structure;Transportation;United States;urban residence;Vulnerable Populations

PROJECT_TITLE: Understanding how living arrangement affects access to and use of personal care services in community-living older adults with disabilities