NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This project utilizes synthetic chemistry, microbiology, genetics, and proteomic methods to develop novel compounds to combat bacteria. This research will develop narrow-spectrum and antivirulence tool compounds as potential therapeutic agents that either inhibit growth or biofilm processes within pathogenic bacteria. The compounds are derived from natural product scaffolds isolated from regions rich in chemical diversity and bioactivity, which will undoubtedly shed light on the chemical underpinnings of these complex microbial communities.

PI_NAMEs: WUEST, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;analog;Area;Bacteria;Biochemical;Biological;Biological Assay;chemical property;chemical synthesis;Chemical Warfare;Chemicals;combat;Complex;design;Development;Disease;Endowment;Environment;Evaluation;fungus;Genetic;Goals;Growth;Health;Human;improved;inhibitor;interest;Invaded;Lead;medical implant;Methods;Microbial Biofilms;microbial community;Microbiology;Molecular Genetics;natural product derivative;natural product inspired;Natural Products;Nature;novel;novel strategies;novel therapeutics;Organic Synthesis;pathogenic bacteria;physical property;Plants;polymicrobial biofilm;prevent;Process;Property;Proteins;Proteomics;Reporting;Research;Resistance development;scaffold;Source;Synthesis Chemistry;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;tool;transcriptomics;Translations;Virulence

PROJECT_TITLE: Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PI_NAMEs: CURIEL CID, ROSIE E (contact)

PROJECT_TERMS: Address;African American;African American population;aging population;Agreement;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Applied Research;Area;Autopsy;Black race;Brain;Clinic;Clinical;Clinical Research;clinical training;Clinical Trials;cohort;Collaborations;Communication;Communities;community academic partnership;community engagement;community organizations;community partners;County;Data;data management;Dementia;dementia risk;Development;Disease;disorder risk;Disparity;Early Diagnosis;Education;Education and Outreach;education research;Educational Materials;Elderly;empowerment;Enrollment;ethnic diversity;ethnic minority;Evaluation;experience;Faculty;Feedback;Florida;follow-up;Follow-Up Studies;Fostering;genetic analysis;Goals;Healthcare;Hispanic;Hispanic Americans;Hispanic Populations;Individual;interest;Knowledge;Language;Literature;Magnetic Resonance Imaging;Measures;Medical center;medical schools;Memory Disorders;Methods;Minority;minority communities;Mission;Monitor;neuroimaging;neuropathology;Neuropsychology;next generation;Not Hispanic or Latino;older adult;outreach;Participant;Persons;PET/CT scan;Phase;Population;Population Heterogeneity;Postdoctoral Fellow;pre-clinical;Prevalence;prevent;programs;racial diversity;racial minority;recruit;recruitment science;Registries;Research;Research Personnel;Research Project Grants;Resources;retention rate;Risk Factors;Scanning;Scientist;Site;Spanish/English;success;tool;Training;Training Activity;Training Support;Underrepresented Minority;underserved minority;Underserved Population;Universities;Update;Work

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Outreach, Recruitment and Engagement (ORE) Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: VAILLANCOURT, DAVID E (contact)

PROJECT_TERMS: African American;African American population;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid;Amyloid beta-Protein;Amyloid deposition;Autopsy;Back;Biological;Biological Assay;Biological Markers;Characteristics;Classification;Classification Scheme;Clinical;Clinical Data;Cognitive aging;cognitive neuroscience;cohort;Communication;computational platform;computerized data processing;Data;data management;Data Set;data sharing;Databases;deep learning;Dementia;demographics;density;Diffusion;Disease Progression;Education;Elderly;Florida;Functional Imaging;Funding;Future;Goals;Grant;healthy aging;Hippocampus;Hispanic Americans;Image;image processing;imaging modality;in vivo;Individual;Infrastructure;innovation;Light;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Measures;Memory Disorders;Mission;Modality;multimodal data;Multimodal Imaging;multimodal learning;multimodality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurites;neurofilament;neuroimaging;novel;Online Systems;Participant;Pathology;Pathway interactions;Plasma;Positron-Emission Tomography;Process;Protocols documentation;Proxy;Publishing;Recommendation;Research;Research Personnel;Research Training;Site;software development;specific biomarkers;structural imaging;support vector machine;tau Proteins;tractography;Universities;Visualization;Water;web services;white matter;Work;β-amyloid burden

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SMITH, GLENN E. (contact)

PROJECT_TERMS: Active Learning;Alzheimer's Disease;career;career development;Caring;Clinical;Clinical Sciences;cohort;Collaborations;Communication;community engagement;Competence;computer science;data management;Development;Discipline;Discipline of Nursing;Disease;disorder prevention;Disparity;education research;Educational Curriculum;Effectiveness;Engineering;Ethnic Origin;Evaluation;experience;Faculty;Florida;Funding;Future;Gender;Goals;health equity;Health Occupations;Health Sciences;Immersion;implementation science;Infrastructure;innovation;Institution;interest;Leadership;leadership development;Learning;Medicine;Mentors;Mind;Molecular Biology;multidisciplinary;Neurology;Neurosciences;next generation;peer coaching;peer support;Pharmacy facility;Policies;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Private Sector;Process;Program Development;programs;Psychology;Public Health;Qualifying;recruit;Research;research and development;Research Personnel;Research Training;Role;Scholars Program;Science;science education;Scientist;Site;skills;success;Training;Translational Research;translational scientist;underserved community;Universities;Veterinary Medicine;Work

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Research Education Core


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA CITY VA MEDICAL CENTER

ORG_STATE: OK

PHR: Post-COVID-19 syndrome is frequent in COVID-19 survivors regardless of acute disease severity. Cognitive impairment, a severely disabling manifestation of post-COVID-19 syndrome, poses particularly difficult challenges for our aging veteran population. Identifying markers of risk for cognitive decline after COVID-19 is crucial for developing effective prevention and treatment strategies. This project will characterize changes in cognition and brain imaging over time and will confirm the association between a platelet biomarker and future risk of cognitive dysfunction after recovering from COVID-19, resulting in better medical care, improved quality of life and decreased financial burden for the VA.

PI_NAMEs: KIRKPATRICK, ANGELIA  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;acute COVID-19;Acute Disease;acute infection;Age;Aging;Biological Assay;Biological Markers;biomarker identification;Blood;Blood Platelets;Blood Vessels;brain fog;Brain imaging;Brain Infarction;Caring;cerebrovascular;Cessation of life;Clinical;Cognition;Cognitive;cognitive testing;cohort;Collagen;Convalescence;COVID-19;COVID-19 neurocognitive sequelae;COVID-19 pandemic;COVID-19 survivors;Cross-Sectional Studies;Data;Dementia;Development;disability;Disabling;Enrollment;Enzyme-Linked Immunosorbent Assay;Event;experimental study;Financial Hardship;Funding;Future;high resolution imaging;human old age (65+);Impaired cognition;improved;Incidence;Infection;innovation;Intervention;Ischemia;Ischemic Stroke;Lesion;Link;Long COVID;Magnetic Resonance Imaging;Measures;Mediating;Medical;Messenger RNA;mild cognitive impairment;military veteran;multidisciplinary;Neurobehavioral Manifestations;Neuropsychological Tests;novel;Patient imaging;Pharmacological Treatment;post SARS-CoV-2 infection;post-COVID-19;pre-pandemic;prevent;Prevention strategy;Proteins;Quality of life;Recovery;Reporting;Research;Rest;Risk;Risk Marker;risk prediction;risk stratification;RNA Sequences;Role;SARS-CoV-2 infection;SARS-CoV-2 infection history;screening;Severity of illness;stroke risk;Survival Rate;Survivors;Symptoms;Testing;Thrombin;Time;Transcript;transcriptome sequencing;Translational Research;treatment strategy;vascular risk factor;Veterans;Work

PROJECT_TITLE: Procoagulant platelets as biomarkers for post-COVID-19 cognitive decline


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Disparities in clinical outcomes are derived from a range of factors that influence quality of care which contributes to racial differences in health-related outcomes. The information that will be obtained from this study will serve as the basis for understanding the factors that contribute to racial-ethnic differences in aphasia and dysphagia outcomes.

PI_NAMEs: ELLIS, CHARLES  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acute;acute care;acute stroke;Address;Aphasia;Attention;Black Populations;Black race;care costs;care providers;care systems;Caring;Characteristics;Clinical;Communication impairment;Communities;community setting;Continuity of Patient Care;Data;Deglutition Disorders;Disadvantaged;Disparity;disparity reduction;econometrics;Environment;Equity;ethnic difference;ethnic disparity;Future;Goals;health care model;health care settings;health difference;health disparity;Health Personnel;Healthcare;Healthcare Systems;Impairment;improved;Individual;Inequity;inpatient service;Institution;Institutional Practice;Intervention;Language;Length;Location;Measures;Medicare claim;minority investigator;Mission;National Institute on Deafness and Other Communication Disorders;Not Hispanic or Latino;Outcome;outcome disparities;Pathway interactions;Patients;people of color;Play;post stroke;Process;Provider;provider behavior;provider factors;public health relevance;Public Policy;Quality of Care;Quality of life;Race;racial difference;racial disparity;Recovery;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;Role;service utilization;Services;social;Speech Therapy;stroke outcome;stroke survivor;stroke therapy;stroke-induced aphasia;System;Techniques;Testing;Time;Translating;treatment services;Variant;Visit;Work

PROJECT_TITLE: Exploring Pathways to Equitable Outcomes in Post-Stroke Aphasia and Dysphagia


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative: Etv4 and Etv5 are required for normal limb, testis, kidney and motor neuron development. In humans they have also been associated with obesity and cancer progression, invasion and metastasis. We aim at elucidating their role in nephrogenesis as well as providing new insight on the mechanisms driving nephron progenitor self-renewal and differentiation.

PI_NAMEs: CEBRIAN LIGERO, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Address;Affect;Automobile Driving;beta catenin;Birth;Cell Maintenance;cell motility;Cells;Cleavage Under Targets and Release Using Nuclease;confocal imaging;Cystic kidney;Data;Defect;Development;Developmental Biology;Distal;Dose;Down-Regulation;Embryo;Embryonic Development;Epithelium;Equilibrium;ETV4 gene;exhaust;exhaustion;Fibroblast Growth Factor;Genetic Transcription;glial cell-line derived neurotrophic factor;Histology;Human;Immunofluorescence Immunologic;In Vitro;Individual;insight;Invaded;Kidney;Knowledge;Limb structure;Link;LoxP-flanked allele;Lung;Malignant Neoplasms;Mediating;Mesenchyme;Metanephric Diverticulum;migration;Modeling;motor neuron development;mouse model;Mus;mutant;Neoplasm Metastasis;nephrogenesis;nephron progenitor;Nephrons;novel;Obesity;Organogenesis;Pathway interactions;postnatal;Pregnancy;premature;prevent;progenitor;Regulation;Role;self-renewal;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell differentiation;stem cell self renewal;stem cells;stemness;Tamoxifen;Testing;Testis;Therapeutic Intervention;Thinness;Tissues;transcription factor;Transcription Repressor;transcriptome sequencing;Tubular formation;tumor progression;Undifferentiated;Up-Regulation;Vesicle;WNT Signaling Pathway;WNT4 gene

PROJECT_TITLE: Role of Etv4 and Etv5 in the self-renewal and differentiation of nephron progenitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Treatment of opioid use disorder with the medication buprenorphine reduces risk of opioid overdose mortality, but poor retention in care limits this medication’s protective effect. This proposal will use large observational data to examine the relationship between buprenorphine dosage strategies and retention by: 1) describing current buprenorphine dosage practices in terms of dosage trajectories, 2) comparing the effect of two distinct buprenorphine dosage strategies on retention, and 3) estimating the impact of improved buprenorphine dosage practices on retention and overdose for the state of Massachusetts. This proposal has the potential to identify improved buprenorphine dosage strategies that increase retention in care, a key pillar in reversing the opioid overdose epidemic.

PI_NAMEs: TILHOU, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Award;Buprenorphine;buprenorphine treatment;career;Caring;Cessation of life;Clinical;Clinical Trials;Complex;cost;cost-effectiveness ratio;craving;Data;Data Science;Databases;Disparity;dosage;Dose;Ensure;Environment;Epidemic;Ethnic Origin;Evidence based treatment;experience;Fentanyl;Goals;Guidelines;Health Insurance;illicit opioid;improved;Incidence;incremental cost-effectiveness;innovation;insurance claims;Intervention;K-Series Research Career Programs;Learning;Literature;Machine Learning;Maintenance;Massachusetts;Medicaid;Mentors;Meta-Analysis;Methodology;Methods;Modeling;models and simulation;mortality;National Institute of Drug Abuse;Observational Study;Opioid;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome Measure;Overdose;overdose prevention;Patient Care;Patients;Penetration;Pharmaceutical Preparations;Pharmacy facility;Physicians;Policies;Population;Positioning Attribute;prevent;Prevention strategy;Primary Care;Privatization;protective effect;Quality-Adjusted Life Years;Race;Recommendation;Records;Regimen;Research;Research Personnel;Resources;retention rate;Risk Reduction;Role;Sample Size;simulation;skills;Speed;Substance Use Disorder;Testing;Therapeutic;Titrations;Training;treatment and outcome;trend;trial comparing;United States Substance Abuse and Mental Health Services Administration;Variant;Withdrawal;Work

PROJECT_TITLE: Impact of initial buprenorphine prescribing strategies on retention in care for patients with opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chromogranin A (CgA), the most ubiquitously distributed protein in the hormone-producing cells in our body, is overexpressed in patients with neuroendocrine and non-neuroendocrine malignancies, heart failure, renal failure, liver dysfunction, hypertension, and numerous autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease as well as in the brains of Alzheimer’s disease patients, implicating that excess CgA is toxic to many cellular activities. We found that lack of CgA in a mouse model caused marked improvements in the age-associated increase in blood pressure and diabetes with consequent increase in healthy lifespan. This proposal will use a transdisciplinary approach to uncover if CgA is a risk factor for aging by analyzing the lifespan of CgA knockout mice and whether removing CgA from adult animals will help ameliorate aging associated development of inflammatory disorders like diabetes and hypertension.

PI_NAMEs: GHOSH, GOURISANKAR ;MAHATA, SUSHIL K (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: adipokines;adiponectin;Adipose tissue;Adrenergic Receptor;Age;age group;age related;age related changes;aged;Aging;aging related;Alzheimer's disease brain;Alzheimer's disease patient;Anti-diabetic Drugs;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Antioxidants;Autoimmune Diseases;Autophagocytosis;Bacterial DNA;Biochemical;Biological Process;Blood;Blood Glucose;Blood Pressure;blood pressure elevation;Blood Vessels;Cardiac;Catecholamines;Cells;Cessation of life;Characteristics;Cholesterol;Chromogranin A;Chronic;Clinical;cohort;Collaborations;Communication;Coupled;Data;Dense Core Vesicle;Development;Diabetes Mellitus;diabetic;Disease;Eating;Endocrine;Energy Metabolism;Exhibits;experimental study;extend lifespan;Extravasation;Fatty Acids;Female;Future;Gene Expression;Gene Expression Profiling;Genes;Goals;Growth;Health;healthspan;Heart;Heart failure;Hormones;human old age (65+);Hypertension;hypertensive;Immunoglobulin Domain;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Insulin;Insulin Resistance;insulin sensitivity;Intestinal permeability;Kidney Failure;Knock-out;Knockout Mice;Life;life span;lipid metabolism;lipoprotein lipase;Lipoproteins;Liver;Liver Dysfunction;Longevity;Longitudinal Studies;Maintenance;male;Malignant Neoplasms;mature animal;Mediating;Messenger RNA;Metabolism;Mitochondria;Modeling;mouse model;Mus;Muscle;Nervous System Disorder;Neuroendocrine Cell;Neurons;Neurosecretory Systems;Neurotransmitters;Norepinephrine;old mice;Organ;overexpression;pancreastatin;Pathogenicity;Pathway interactions;Patients;peptide hormone;Peptides;Physiological;Physiology;Plasma;Process;prohormone;Proteins;Proteolytic Processing;Publishing;Regulation;Reporting;Research;resistance gene;Respiration;Rheumatoid Arthritis;Risk Factors;Role;SET Domain;Signal Pathway;Signal Transduction;targeted treatment;Testing;Tissue Sample;Tissues;Transcript;transcriptome sequencing;Triglycerides;Tumor Suppressor Proteins;Wild Type Mouse

PROJECT_TITLE: Chromogranin A is an aging risk factor

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narratives  The liver transplant (LT) program for acute alcoholic hepatitis (AH) at Johns Hopkins provided a unique opportunity for us to create a clinical resource that now serves the alcohol research community and facilitates access to otherwise unavailable specimens. We propose to continue meeting investigators’ current and increasing needs and liberally provide our resource to the entire alcohol research community. Hopefully, given the enhanced efficiency of collaboration, a nationwide team can make progress towards better care and therapeutics for this difficult patient population.

PI_NAMEs: SUN, ZHAOLI  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acute;Acute Alcoholic Hepatitis;Adrenal Cortex Hormones;Alcohol consumption;alcohol research;Alcoholic Hepatitis;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Animal Model;Basic Science;Biopsy;Blood specimen;Caring;Cell Separation;cell type;Cells;Cholestasis;Cirrhosis;Clinical;Clinical Research;Collaborations;Collection;Communities;COVID-19;COVID-19 pandemic;Data;data mining;Data Set;Databases;design;Development;Discontinuous Capillary;Disease;Endothelial Cells;Ethanol;Ethanol Metabolism;experimental study;feeding;Fibrosis;Funding;Gastroenterology;Generations;Goals;Grant;Hepatic Stellate Cell;Hepatocellular Damage;Hepatocyte;Hepatology;Human;human data;human tissue;Infiltration;Inflammation;innovation;Institution;Investigation;Journals;Knowledge;Kupffer Cells;Laboratories;Lead;Liver;Liver diseases;liver inflammation;liver injury;liver transplantation;Lymphocyte;Maps;meetings;Modeling;Molecular;mortality;Mouse Strains;new therapeutic target;Noise;nonalcoholic steatohepatitis;novel therapeutic intervention;Paper;Paraffin;Pathogenesis;Pathology;patient population;Patients;Post-Translational Protein Processing;Preparation;Principal Investigator;Prognosis;programs;Proteome;Proteomics;Publications;Publishing;R24;Research;Research Personnel;Resources;Rodent;Sampling;Serum;single-cell RNA sequencing;Specimen;Supportive care;Therapeutic;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Universities

PROJECT_TITLE: Clinical Resource for Alcoholic Hepatitis Inestigation

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Social isolation and loneliness have risen at alarming rates among young adults, placing this cohort at heightened risk for poor physical and mental health, especially in populations that already face higher burdens of disease. We propose basic experimental research on social connectedness to discover whether, how, where, and for whom health communication, optimized for social media, can ameliorate social isolation in these at-risk populations.

PI_NAMEs: FREDRICKSON, BARBARA LEE (contact);LAZARD, ALLISON JOAN

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: African American;Age;age group;Alcohol consumption;Anxiety;Basic Science;behavior change;Behavioral;Black race;burden of illness;Caring;Cellular Phone;cohort;Communication;COVID-19;Data;Data Analyses;depressive symptoms;design;digital delivery;Discrimination;disparity reduction;Economics;Emotional;Emotions;Ethnic Origin;evidence base;experimental study;Face;Feeling;Goals;Health;Health behavior;health communication;health disparity;health disparity populations;Hispanic;Home;Human;Imagery;improved;indexing;Inequality;innovation;Intervention;intrinsic motivation;Knowledge;knowledge base;Latino;Life;Link;Loneliness;Measures;Mediator;Mental Health;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Outcome;Patient Self-Report;peer;Personal Satisfaction;Persons;physical conditioning;Placebo Control;Population;Populations at Risk;positive emotional state;Process;programs;Protocols documentation;Race;Randomized, Controlled Trials;Reaction Time;Recommendation;Reporting;Reproducibility;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Safety;Sampling;Science;social;Social Behavior;Social Environment;Social Interaction;Social isolation;social media;Social Psychology;social structure;Social Values;Socioeconomic Status;socioeconomics;Spanish/English;Statistical Models;stem;Surveys;Symptoms;Testing;Text;theories;Time;Visual;Work;young adult

PROJECT_TITLE: Ameliorating Social Isolation in Populations Facing Health Disparities: Identifying Social Structural and Person-level Factors that Impede or Facilitate Health-related Social Behavior Change

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Lung;Prevention

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Pressure Sensitive Adhesives For Use in Thoracic Surgery PROJECT NARRATIVE A pleural fistula, or opening between the pleural cavity and lung parenchyma or airway, originates from injury or locally invasive cancer. Closure of alveolar- and broncho- pleural fistulae remains a serious surgical challenge with high morbidity or death, and one where new biomaterial-based adhesives are needed. The performance and evaluation of novel biodegradable, biocompatible pressure sensitive adhesives, with tunable adhesion strength, is described for in vivo closure of pleural fistulae despite an inherent pressure gradient.

PI_NAMEs: COLSON, YOLONDA L;GRINSTAFF, MARK W. (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acrylates;Adherence;Adhesions;Adhesives;Air;Air Movements;Alveolar;Bacteria;Bacterial Infections;Bandage;Benign;Biocompatible Materials;biocompatible polymer;biomaterial compatibility;Bronchial Injury;Bypass;cancer invasiveness;Carbon Dioxide;Carbonates;Cessation of life;Chemical Structure;Clinical;Collaborations;Collagen;comparative;cytotoxicity;Data;Death Rate;Duct (organ) structure;Endothelium;Epithelium;Ethanol;ethylene glycol;Evaluation;Excision;Exhibits;Experimental Designs;experimental study;Family suidae;Fibroblasts;Fistula;Formulation;functional mimics;Glass;Glyceric Acids;Glycerol;Guidelines;healing;Health Care Costs;Human;Hydrophobicity;implantation;improved;In Vitro;in vivo;in vivo Model;Infection;Injury;innovative technologies;Libraries;Liquid substance;Lung;lung injury;Macrophage;mechanical behavior;Medical;Medical Device Safety;Metals;migration;Modeling;Molecular Weight;Morbidity - disease rate;mortality;Mus;Muscle;novel;Oligonucleotides;Operative Surgical Procedures;Oral;organ injury;Paper;Patient Care;Performance;Pleural;Pleural cavity;poly(lactide);polyacrylate;Polymers;porcine model;pressure;prevent;Prevention;Procedures;Property;Pulmonary valve structure;repaired;Respiration;Respiratory physiology;response;seal;sealant;Secure;Series;Steel;Structure;Structure of parenchyma of lung;Surface;Surgical Staplers;Surgical sutures;Testing;Thoracic Surgical Procedures;Tissues;Wood material;wound

PROJECT_TITLE: Biodegradable, Biocompatible Pressure Sensitive Adhesives

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: EY

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE  Retinal degenerations are a major cause of blindness in developed countries, producing signiﬁcant disability and burden to public health; developing therapies is a key goal for the National Eye Institute. The most promising (and still experimental) therapies, aimed at replacing the lost photoreceptors by either stimulating regeneration of the retina or by cellular transplantation, are still unsuccessful and have exposed gaps in our knowledge about the mechanisms that control the normal integration of photoreceptors into functional retinal circuits. This proposal aims to discover and study such mechanisms, with the aspiration to apply this knowledge to the development of therapies for retinal degenerations.

PI_NAMEs: ANGUEYRA, JUAN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adult;aspirate;Award;Blindness;Candidate Disease Gene;career;Cause of Death;cell replacement therapy;Cell Transplantation;cell type;Cells;Color;Cone;CRISPR/Cas technology;Degenerative Disorder;Developed Countries;Development;differential expression;direct application;disability;Dissociation;Electron Microscopy;Electroretinography;Exhibits;Gene Expression Profile;Genes;genetic profiling;Genetic Screening;Goals;horizontal cell;Immunohistochemistry;improved;insight;Institution;knockout gene;Knowledge;Label;Laboratories;Larva;Measures;molecular recognition;Morphology;Muller's cell;Mutagenesis;mutant;National Eye Institute;Nerve Degeneration;Nervous System;neural circuit;Neurons;novel;Opsin;Photoreceptors;postsynaptic;Principal Investigator;Process;programs;Public Health;regenerative;regenerative therapy;Replacement Therapy;Reporter;Repression;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal regeneration;retinal stimulation;reverse genetics;ribbon synapse;Sorting;Specificity;stem cells;Structure;success;Synapses;synaptogenesis;Testing;Therapeutic;therapy development;tool;transcriptome sequencing;transcriptomic profiling;Transgenic Organisms;treatment strategy;Vision;Visual;Zebrafish

PROJECT_TITLE: Identification of genes involved in photoreceptor recognition and synapse formation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE Dysregulation in the activity of mitochondrial inner membrane proteases are implicated in the pathologic mitochondrial dysfunction associated with multiple diseases including many neurodegenerative disorders. However, the molecular mechanisms responsible for the regulation and activity of these proteases remain poorly defined. Here, we employ a combined structural and functional genomic approach to determine how inner membrane proteases perform the diverse biological functions involved in regulating mitochondria to reveal new insights into the pathologic and potentially therapeutic implications of altered protease activity in the context of human diseases.

PI_NAMEs: LANDER, GABRIEL C;WISEMAN, ROCKLAND LUKE (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Alzheimer's Disease;Apoptotic;Award;Binding;Biological;Biological Process;Biology;Catalytic Domain;Cells;Cellular biology;Chronic;Cryoelectron Microscopy;Disease;Endowment;Energy Metabolism;Environmental Risk Factor;Etiology;functional genomics;functional/structural genomics;Genetic Induction;Genomic approach;Genomics;Goals;Guanosine Triphosphate Phosphohydrolases;Hand;Health;Hereditary Spastic Paraplegia;human disease;Inner mitochondrial membrane;insight;Membrane;Metalloproteases;Mitochondria;mitochondrial dysfunction;Molecular;Morphology;Mutation;mutation screening;Neurodegenerative Disorders;Nucleotides;OPA1 gene;Parkinson Disease;Pathogenesis;Pathologic;Peptide Hydrolases;pharmacologic;Proteolysis;proteostasis;Regulation;Resolution;response;Signal Transduction;Site;Spinocerebellar Ataxias;Stress;Structure;Structure-Activity Relationship;Therapeutic;therapeutic target;Zinc

PROJECT_TITLE: IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE While bacteria are single-celled organisms, biofilm communities exhibit multicellular behaviors that allow individual bacteria to resist antibiotics and survive in harsh environments. The goal of this MIRA proposal is to uncover how emergent metabolic coordination and cell-to-cell signaling give rise to these collective behaviors in biofilms. This proposed work is relevant to the NIH because it will reveal new ways to target the unique properties that make biofilms resilient.

PI_NAMEs: PRINDLE, ARTHUR  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: antibiotic tolerance;Antibiotics;Award;Bacillus subtilis;Bacteria;bacterial community;Behavior;Biological;cell behavior;Cells;Communication;Communities;Data;Environment;Exhibits;Feedback;Gene Expression Regulation;gene regulatory network;Goals;Individual;infancy;Ion Channel;Mediating;Metabolic;Microbe;Microbial Biofilms;Microfluidics;Microscopy;Modeling;Molecular;Nature;next generation sequencing;Organism;polymicrobial biofilm;Property;Public Health;Quantitative Genetics;resilience;Role;Signal Transduction;System;United States National Institutes of Health;Work

PROJECT_TITLE: Emergent metabolic coordination and cell-to-cell signaling in bacterial biofilms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Racial and ethnic minority children who live in socio-economically disadvantaged communities are disproportionately impacted by pandemic and climate-induced disasters. Although effective interventions have been designed to treat mental health related symptoms in post-disaster settings, accessible, empirically supported prevention interventions are needed to prevent the onset of mental and behavioral health issues among these children. Building on our preliminary findings, the proposed study examines the efficacy and implementation of a COVID-19 adapted disaster focused prevention intervention, Journey of Hope-C19, in preventing behavioral health and interpersonal problems among racial and ethnic minority children who live in low-resource high poverty communities.

PI_NAMEs: LEYTHAM-POWELL, TARA  (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Affect;Alabama;Anxiety;arm;attentional control;Attenuated;Behavior;behavioral health;behavioral health intervention;Caregivers;Child;Childhood;Climate;Communities;community engaged intervention;community organizations;Consolidated Framework for Implementation Research;Control Groups;coping;Coping Behavior;Coping Skills;Coupled;COVID-19;COVID-19 impact;COVID-19 pandemic;design;Diagnosis;Disadvantaged minority;Disasters;Distress;Education;effective intervention;efficacy evaluation;eighth grade;Elements;emotional distress;ethnic minority;experience;Exposure to;Family;follow up assessment;Future;future pandemic;Goals;health disparity;healthy lifestyle;high risk;Hurricane;implementation barriers;improved;Individual;Intervention;intervention effect;Life Cycle Stages;Link;Mediating;Mental Depression;Mental disorders;Mental Health;Mental Health Services;minority children;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;neighborhood disadvantage;New Zealand;Oklahoma;Outcome;pandemic disease;pandemic impact;Parents;pediatric trauma;peer;peer support;physical health service;poor communities;post intervention;Poverty;Poverty Areas;preservation;prevent;Prevention;Prevention program;preventive intervention;Professional counselor;prospective;protective factors;public health emergency;racial minority;Randomized;Randomized, Controlled Trials;Research;Resources;Risk;Safety;SARS-CoV-2 exposure;Schools;Security;Self Efficacy;skills;social;social health determinants;socioeconomic disadvantage;stressor;Symptoms;therapy design;Time;United States;Well in self;Wildfire

PROJECT_TITLE: Pragmatic RCT of a multi-level mechanistically informed community intervention to prevent the onset of behavioral health symptoms among socioeconomically disadvantaged pandemic affected children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE We have identified a class of microbial metabolites, present within the intestine, that potently represses functions of Salmonella required for this pathogen to colonize and cause disease. We aim to identify the bacterial sources of these signals within the gut microbiome and to characterize their global effects on Salmonella virulence functions. This work is innovative and impactful as it investigates a novel means to reduce the public health threat of salmonellosis.

PI_NAMEs: ALTIER, CRAIG  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acids;Affect;Affinity;Animal Model;Animals;Bacteria;Bacterial Adhesins;Bacterial Infections;Behavior;Binding;Biochemical;Biological Assay;Biological Process;Biological Response Modifier Therapy;Carbon;Cause of Death;Cell Adhesion;Characteristics;Chemicals;combat;Complex;cost;Development;Disease;Energy-Generating Resources;Enoyl-CoA Hydratase;enteric pathogen;Environment;Epithelial Cells;Equilibrium;Ethanolamines;Excretory function;Fatty Acids;fitness;foodborne;Gene Expression;gene function;Genes;Genetic;Goals;Gram-Negative Bacteria;gut colonization;gut microbiome;gut microbiota;Human;human disease;human model;improved;in vivo;Infection;innovation;interspecies communication;intestinal epithelium;Intestines;Invaded;Large Intestine;long chain fatty acid;Macrophage;Measures;member;Metabolic;microbial;microbiota;microbiota composition;microbiota metabolites;Molecular;mouse model;Mus;novel;novel therapeutics;Nutrient;Organ;Organism;Outcome Study;pathogen;Phenotype;pi bond;Population;Positioning Attribute;prevent;Problem Sets;Proliferating;Public Health;quorum sensing;Regulon;Repression;response;Salmonella;Salmonella infections;Signal Transduction;Source;System;Testing;tool;Transcription Coactivator;Virulence;Work

PROJECT_TITLE: Microbial Metabolites Inhibiting Salmonella Carriage and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-N(80)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Climate-Related Exposures and Conditions;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative This project will use individual-level administrative Medicare data to estimate the short- and long-run effects of natural disasters such as hurricanes, tornadoes, and floods on health, health care use, and health-related expenditures among the elderly and people with long-term disabilities. The project will also assess several mechanisms that could moderate or exacerbate post-disaster mortality and disease impacts, including disruptions in continuity-of-care and characteristics in areas to which victims relocate following a disaster.

PI_NAMEs: DERYUGINA, TATYANA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Adult;Affect;Age;age related;Alzheimer's Disease;Area;Behavior;beneficiary;burden of illness;Cessation of life;Characteristics;Chronic;Chronic Disease;climate change;Communities;Community Participation;Continuity of Patient Care;Control Groups;cost;Data;Data Sources;Databases;Dementia;design;Diagnosis;Digit structure;Dimensions;disability;disabled;Disasters;Disease;Disease Progression;Elderly;Event;Excess Mortality;Exhibits;Expenditure;Floods;Frequencies;Government;hazard;Health;health care availability;Health care facility;health plan;Healthcare;Hurricane;improved;Income;Individual;Insurance;local economy;Local Government;Location;Long term disability;Low income;Machine Learning;Maps;Mediating;Medicaid eligibility;Medical;Medicare;Medicare claim;Morbidity - disease rate;mortality;Natural Disasters;Obesity;older adult;Outcome;Personal Satisfaction;Persons;Physicians;Policies;Population;Preparation;Prevalence;programs;Proxy;Public Health;Public Policy;Race;Readiness;Recording of previous events;Records;Research;Research Personnel;residence;resilience;response;Risk;Role;Running;Sampling;Severities;sex;Source;Surveys;System;Time;Tornadoes;trait;treatment group;trend;Vulnerable Populations

PROJECT_TITLE: The Long-Run Impacts of Natural Disasters on Mortality and Disease Burden Among US Elderly and Disabled Adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE_OVERALL Pneumonia is the most common cause of death from an infectious disease worldwide and disproportionately affects the elderly. Most elderly patients survive pneumonia, but they have an increased chance of developing ongoing lung inflammation, skeletal muscle dysfunction and cognitive decline. We show that metabolic interventions that restore proteostasis in older animals can accelerate recovery after pneumonia with implications for therapy.

PI_NAMEs: BUDINGER, GR SCOTT  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;activating transcription factor 4;Address;Affect;Age;age related;age-related disease;aged;Aging;Alveolar Macrophages;animal old age;Award;Binding;Biological;biological adaptation to stress;Biology of Aging;Brain;Caenorhabditis elegans;Cause of Death;Cells;Cessation of life;Chronic Kidney Failure;Chronology;clinically relevant;Cognitive deficits;cognitive function;Communicable Diseases;Complex;Data;Data Set;Dementia;Disease;Elderly;Electron Transport;end of life;Endocrine;Environmental Pollution;environmental stressor;Event;frailty;Friends;Functional disorder;Geroscience;Healthcare;healthspan;Hospitals;Human Biology;Immobilization;Immune;Impaired cognition;Impairment;improved;Individual;Infection;influenza A pneumonia;Influenza A virus;inhibitor;Injury;Intervention;Laboratories;life span;Lung;lung injury;lung repair;Macrophage;Metabolic;Microglia;Mitochondria;Mitochondrial Electron Transport Complex I;mitochondrial metabolism;Modeling;Modernization;Molecular Conformation;Morbidity - disease rate;Motor;Mus;Muscle function;Mutant Strains Mice;Myocardial Infarction;older men;older patient;Older Population;Organ;overtreatment;pandemic influenza;Pathway interactions;Play;Pneumonia;pneumonia treatment;Process;Productivity;programs;promote resilience;Protein Biosynthesis;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Publishing;Pulmonary Inflammation;receptor function;Recovery;Regulatory T-Lymphocyte;repair function;repaired;Research Personnel;resilience;Respiratory Failure;response;Risk;Role;scavenger receptor;Scientist;seasonal influenza;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Stress;Survivors;System;targeted treatment;Testing;Time;Tissues;trafficking;transcriptomics;Virus Diseases

PROJECT_TITLE: Disordered Proteostasis as a Driver of Disease in the Aging Lung


NIH_SPENDING_CATS: Aging;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: PROJECT NARRATIVE It is not required per instructions stated on the Funding Opportunity Announcement PAR-18-297, Section IV. Application and Submission Information, Project, Research & Related Other Project Information (Core), “Project Narrative: Do not complete”.

PROJECT_TERMS: activating transcription factor 4;Address;Advisory Committees;Age;age related;age-related disease;Aging;Alveolar Macrophages;Award;Binding;Biological;biological adaptation to stress;Biology of Aging;Brain;Caenorhabditis elegans;Cells;Cessation of life;Chronic Kidney Failure;Chronology;Collaborations;collaborative environment;Committee Members;Communication;Complex;Dementia;Disease;Doctor of Philosophy;Elderly;end of life;Endocrine;Environment;Environmental Pollution;environmental stressor;Event;Excess Mortality;experimental study;Fostering;frailty;Friends;Functional disorder;Funding Opportunities;Geroscience;Healthcare;healthspan;Hospitals;Immobilization;Immune;Impaired cognition;Impairment;improved;Individual;Information Dissemination;Injury;innovation;Institution;Instruction;Interdisciplinary Study;Intervention;Lung;lung injury;lung repair;Macrophage;member;Metabolic;Mitochondria;mitochondrial metabolism;Modeling;Modernization;Molecular Conformation;Morbidity - disease rate;Myocardial Infarction;older men;older patient;Older Population;Pathway interactions;Pneumonia;Postdoctoral Fellow;Principal Investigator;Process;programs;promote resilience;Protein Biosynthesis;Proteins;Proteome;Proteomics;proteostasis;Publications;Reagent;Recovery;Regulatory T-Lymphocyte;repaired;Research;Research Personnel;resilience;response;Risk;Services;Signal Transduction;Skeletal Muscle;Stress;Structure;student mentoring;Survivors;System;targeted treatment;Techniques;Testing;Time;Tissues;trafficking;transcriptomics

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence

PHR: PROJECT NARRATIVE  It is not required per instructions stated on the Funding Opportunity Announcement PAR-18-297, Section IV.  Application and Submission Information, Project, Research & Related Other Project Information (Core),  “Project Narrative: Do not complete”.

PI_NAMEs: MISHARIN, ALEXANDER  (contact)

PROJECT_TERMS: Acceleration;Aging;Alveolar Macrophages;alveolar type II cell;animal old age;Animals;Award;Biological;biological adaptation to stress;Biology;Biology of Aging;Brain;brain tissue;Cell Physiology;Cell Separation;Cells;Collection;Complex;Coupled;Data;data integration;Data Set;Dimensions;Disease;DNA;Electronics;Environment;extend lifespan;Flow Cytometry;Funding;Funding Opportunities;Genetic;Genetic study;Genomics;Genotype;Health;healthspan;Human;Impairment;Infection;Influenza A virus;Informatics;Injury;injury recovery;Instruction;Intervention;life span;Link;Lung;Lung Diseases;lung health;lung repair;Machine Learning;Macrophage;Mass Spectrum Analysis;Membrane;Metabolism;Metformin;Methods;Microglia;Mitochondria;Modeling;Monitor;mouse model;multiple omics;Muscle;Muscle satellite cell;novel;old mice;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phenotype;Pneumonia;Population;Protein Biosynthesis;protein complex;protein folding;Proteins;Proteome;Proteomics;proteostasis;Protocols documentation;Publishing;Recovery;repaired;Research;Research Personnel;response;RNA;Sampling;Science;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;skeletal tissue;Sorting;Stress;Structure of parenchyma of lung;System;Technology;Tissue Harvesting;tissue injury;tissue mapping;Tissues;tool;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Monitoring the aging lung using genomics, proteomics and informatics


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Mental Health;Neurosciences;Pneumonia;Pneumonia and Influenza

PI_NAMEs: RIDGE, KAREN M (contact)

PROJECT_TERMS: Acceleration;age related changes;aged;Aging;Alveolar;Animal Model;Attention;behavior test;Biological Assay;Blinded;Brain;Breeding;cell type;Cells;cost;cytokine;Disease;Enterobacteria phage P1 Cre recombinase;Environment;Equilibrium;experience;Exploratory Behavior;falls;Flow Cytometry;Funding Opportunities;Generations;Genes;Genetically Engineered Mouse;Genotype;Human Resources;Immune;indexing;Inflammatory;influenza A pneumonia;Influenza A virus;influenza infection;Injury;Instruction;interest;Intervention;Knock-out;knockout animal;Knockout Mice;Learning;Liquid substance;LoxP-flanked allele;Lung;lung injury;lung repair;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurement;Measures;Mechanics;Memory;Modeling;Monitor;Motor;Motor Activity;mouse model;Mus;Muscle;Muscle function;neurobehavioral;Nociception;novel;object recognition;old mice;Organ;Outcome Measure;Pathway interactions;Phenotype;Pneumonia;Population;Program Research Project Grants;programs;proteostasis;Protocols documentation;Pulmonary Inflammation;Reaction;recruit;Reproducibility;Research;Research Personnel;Resources;Response Latencies;Rotarod Performance Test;Running;Skeletal Muscle;Sorting;Standardization;synergism;Techniques;Testing;Tissues;tool;transcriptomics;Travel;Virus Diseases

PROJECT_TITLE: Tissue and neurobehavioral phenotyping core


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obesity in childhood is highly prevalent and associated with increased risk of cardiovascular disease, asthma, diabetes, certain cancers, and poorer quality of life. Despite much national attention and research, the prevalence of obesity continues to rise, and disparities persist, suggesting a large gap between research and practice. We will evaluate the dissemination and implementation of a proven-effective intervention for childhood obesity to accelerate the intervention’s adoption in different settings serving populations disproportionately affected by obesity and improve population-level outcomes in obesity.

PI_NAMEs: SHARIFI, MAHNOOSH  (contact)

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Acceleration;Address;Adolescent;Adoption;Adult;Affect;Age;Alabama;Asthma;Attention;Award;Body mass index;California;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;Child;Childhood;Clinical;Collection;Communities;community engaged research;community intervention;Consolidated Framework for Implementation Research;contextual factors;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Data;Diabetes Mellitus;Disparity;Dissemination and Implementation;Educational Curriculum;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness study;effectiveness/implementation design;Ethnic Origin;Evaluation;Evidence based intervention;Evidence based treatment;Family;follow-up;formative assessment;Geographic Locations;Geography;Health;health care service utilization;health economics;high risk;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;informant;innovation;International;Intervention;intervention cost;Interview;Literature;Location;Low Income Population;Maine;Malignant Neoplasms;Mediating;Methods;Modeling;mortality;Obesity;Obesity associated cancer;obesity in children;obesity risk;obesity treatment;Outcome;patient population;Patients;Phase;Population;Prevalence;prevent;Process;programs;prospective;Provider;Public Health;Publishing;Quality of life;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Methodology;Resources;Rural;scale up;school based health center;simulation;Site;Site Visit;social;Surveys;theories;Time;tool;trend;United States;United States Preventative Services Task Force;user centered design;Weight;Well in self;Work

PROJECT_TITLE: Dissemination and Implementation of the Bright Bodies Intervention for Childhood Obesity

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Regenerative Medicine

PHR: PROJECT NARRATIVE It is not required per instructions stated on the Funding Opportunity Announcement PAR-18-297, Section IV. Application and Submission Information, Project, Research & Related Other Project Information (Project), “Project Narrative: Do not complete”.

PROJECT_TERMS: Acceleration;activating transcription factor;activating transcription factor 4;age related;age-related disease;aged;Aging;Air;Alveolar;Alveolar Macrophages;Alzheimer's Disease;animal old age;Animals;Area;Award;biological adaptation to stress;Caenorhabditis elegans;Cause of Death;Cell Separation;Cessation of life;Chronic Kidney Failure;Clinical;Communicable Diseases;Complex;Data;Dementia;Disease;Effector Cell;Elderly;Electron Transport;end of life;Experimental Genetics;Flow Cytometry;Friends;Functional disorder;Funding Opportunities;Genes;Genetic Transcription;Healthcare;healthspan;Hospitals;Immobilization;Immune;Immune System Diseases;Impaired cognition;Impairment;improved;Infection;influenza A pneumonia;Influenza A virus;Inhalation;inhibitor;Injury;Instruction;juvenile animal;Link;Lung;lung injury;lung repair;Macrophage;Mediating;Metformin;Mitochondria;Mitochondrial Electron Transport Complex I;Modernization;monocyte;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;old mice;older men;older patient;particle;pathogen;Pathway interactions;Play;Pneumonia;Population;Predisposition;promote resilience;Proteomics;proteostasis;re-epithelialization;Recovery;recruit;repair function;repaired;Research;resilience in aging;response;Risk;Role;scavenger receptor;Sentinel;single-cell RNA sequencing;Skeletal Muscle;small molecule inhibitor;Stress;Survivors;synergism;Testing;tissue repair;Tissues;Toxin;Transcriptional Activation;transcriptomics;Translational Repression;Work

PROJECT_TITLE: Alveolar Macrophages as Age-Related Drivers of Disordered Tissue Repair


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine

PI_NAMEs: CHANDEL, NAVDEEP S (contact)

PROJECT_TERMS: 1 year old;Acceleration;activating transcription factor;activating transcription factor 4;Age;age related;aged;Aging;Alveolar;alveolar epithelium;biological adaptation to stress;Caenorhabditis elegans;Catalytic Domain;Cause of Death;Cell Death Induction;Cells;Cessation of life;Complex;Cytoprotection;Data;Disease;DNA;Electron Transport;Epithelial Cells;Epithelium;Exposure to;Functional disorder;Funding Opportunities;Goals;Heterozygote;Homeostasis;Human;human old age (65+);human tissue;Hypermethylation;Immune;Impairment;improved;Individual;Infection;Influenza;Influenza A virus;Instruction;Knockout Mice;life span;Loss of Heterozygosity;Lung;lung injury;lung repair;Mitochondria;Mitochondrial Electron Transport Complex I;Modeling;Mus;NADH;Natural regeneration;normal aging;old mice;Oxidative Phosphorylation;pathological aging;Pathology;Pathway interactions;pharmacologic;Phenotype;Pneumonia;Predisposition;prevent;pro-aging;Production;Proteins;proteostasis;Pulmonary Pathology;Reactive Oxygen Species;Recovery;Regulatory T-Lymphocyte;repaired;Reporting;Research;Research Personnel;Respiration;Respiratory physiology;response;Severities;Signal Transduction;Site;small molecule;Stress;System;Testing;tissue repair;Tissues;Toxic effect;Virus Diseases

PROJECT_TITLE: Modulating mitochondrial function to promote proteostasis in the aging lung


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Machine Learning and Artificial Intelligence;Precision Medicine;Pregnancy

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Given that there are very few proven treatments for unexplained recurrent pregnancy loss, uncovering genetic mechanisms is crucial for identifying individuals at risk and initiating targeted, patient-centered treatments. The proposed work will provide unprecedented machine learning analysis to define the spectrum of genomic and clinical indicators for recurrent pregnancy loss, unparalleled molecular phenotyping through metabolomics and single cell RNA sequencing, and development of a publicly-available “intolerome” database which will provide the foundation for a future prenatal OMIM.

PI_NAMEs: LATHI, RUTH B (contact);RAJKOVIC, ALEKSANDAR ;SIROTA, MARINA ;SNYDER, MICHAEL P.

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: adverse pregnancy outcome;Affect;Anatomy;biobank;Bioinformatics;Biological;Catalogs;Circulation;Clinical;clinical phenotype;cohort;Collaborations;Communities;Complex;Conceptions;Couples;Data;data repository;Data Set;Databases;Development;Diagnosis;Disease;early pregnancy;epidemiology study;Essential Genes;Etiology;exome sequencing;experience;Fathers;Foundations;Frustration;Funding;Future;gene conservation;gene regulatory network;Genes;Genetic;Genetic Databases;Genetic Determinism;Genetic study;genetic variant;genome sequencing;genome wide association study;genomic biomarker;genomic locus;Genomics;Genotype;Goals;Hematology;Heritability;Human;Immune;improved;Individual;innovation;insight;Intervention;learning strategy;lipidomics;Machine Learning;metabolomics;Molecular;molecular marker;molecular phenotype;Molecular Profiling;Mothers;multidisciplinary;Multiomic Data;multiple omics;novel;Online Mendelian Inheritance In Man;Parents;Pathway interactions;patient oriented;Patients;Phenotype;phenotypic data;Precision Health;precision medicine;predictive modeling;Pregnancy;Pregnancy loss;Pregnancy Outcome;prenatal;Prenatal Diagnosis;protein protein interaction;Provider;Recommendation;recruit;Recurrence;reproductive;reproductive system disorder;Research;Risk;risk mitigation;risk prediction;risk prediction model;risk variant;Seminal;single-cell RNA sequencing;Source;Spontaneous abortion;Structural Congenital Anomalies;Systems Biology;Testing;transcriptomics;treatment center;whole genome;Work

PROJECT_TITLE: Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Neurosciences;Pneumonia;Pneumonia and Influenza;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE  It is not required per instructions stated on the Funding Opportunity Announcement PAR-18-297, Section IV.  Application and Submission Information, Project, Research & Related Other Project Information (Project),  “Project Narrative: Do not complete”.

PROJECT_TERMS: activating transcription factor 4;age related;age related changes;age-related disease;aged;Aging;animal old age;Apoptotic;Award;Bacterial Pneumonia;behavior test;biological adaptation to stress;Brain;Cell Proliferation;Chronic Kidney Failure;Cognitive;cognitive function;cognitive recovery;Complex;Data;Dementia;Disease;Distant;Elderly;end of life;Endocrine;Exhibits;Flow Cytometry;Functional disorder;Funding Opportunities;Gene Expression;Genes;Genetic;Healthcare;healthspan;Impaired cognition;Impairment;improved;Individual;Infection;influenza A pneumonia;Influenza A virus;injury and repair;Instruction;Interleukin-6;juvenile animal;Learning;Link;Literature;Lung;lung injury;Macrophage;Memory;Microglia;Mitochondria;mitochondrial metabolism;Mobility decline;Modernization;Molecular;Molecular Chaperones;molecular marker;Morbidity - disease rate;Motor;mouse model;Mus;Muscle;Muscle function;muscle repair;Muscle satellite cell;Muscular Atrophy;Myocardial Infarction;Neurocognitive Deficit;old mice;Organ;Pathway interactions;Patients;Phagocytosis;pharmacologic;Phenocopy;Physiological;Pneumonia;prevent;Process;Proliferating;proteostasis;receptor function;Recovery;Research;response;Risk;scavenger receptor;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Sorting;Survivors;targeted treatment;Testing;Tissues;transcriptome;transcriptomic profiling;ubiquitin-protein ligase;Up-Regulation;Viral Pneumonia;Viremia

PROJECT_TITLE: Activating proteostasis in aging resident macrophages to prevent muscle and cognitive dysfunction after pneumonia


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The long-term goal of this project is to deepen our understanding of the role of  peripheral monocytes and microglia in Parkinson’s Disease (PD) and to identify  myeloid-related targets for treatment of the disease. If successful, discoveries from this  study will provide a foundation for more ambitious plans to identify potential mechanisms and  modulating factors for the increased risk of PD. Our proposed work may explain the causes of PD and  have the potential to lead to new therapeutic targets for PD.

PI_NAMEs: RAJ, TOWFIQUE  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Affect;Age;aging related disease;arm;Autophagocytosis;Autopsy;Brain;causal variant;CD14 gene;Cell Physiology;Cells;Clinical Data;cognitive function;cohort;comparison control;Data;Data Analyses;Data Set;differential expression;Disease;disease model;disorder risk;follow-up;Foundations;Functional disorder;functional genomics;Future;Gene Expression;Generations;Genes;genetic association;Genetic Diseases;Genetic Polymorphism;genetic risk factor;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Heterogeneity;Human;Immune;immune function;Immune system;Impairment;Individual;innate immune function;interest;Link;Macrophage;Maps;Measures;Mediating;Microglia;Mitochondria;mitochondrial dysfunction;Molecular;monocyte;Motor;multi-scale modeling;Multiomic Data;Myelogenous;Myeloid Cells;Neurodegenerative Disorders;new therapeutic target;novel diagnostics;novel therapeutic intervention;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peripheral;Phagocytes;Pharmaceutical Preparations;Phenotype;Proteins;Proteome;Quantitative Trait Loci;rare variant;Research;Resources;Risk;risk variant;Role;sample collection;Signal Transduction;standard care;Subgroup;Susceptibility Gene;Symptoms;System;T-Lymphocyte;Technology;Testing;therapeutic development;transcriptome;transcriptomics;Translational Research;validation studies;Variant;Visit;Work

PROJECT_TITLE: The Role of Myeloid Cells in Parkinson's Disease

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: SAINT LOUIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project narrative Post-traumatic osteoarthritis (PTOA), which affects more than 3 million Americans and totals billions of dollars in socioeconomic costs, is typically initiated following an injury to the knee, followed by joint instability, which then progresses to a state of excruciating pain and limited mobility. Despite the huge impact of osteoarthritis on American society, there have not been significant breakthroughs in the treatment of this disease. Our aim is to provide an injectable solution for the treatment of PTOA, through the fabrication of super-lubricious microspheres loaded with a concentration of bioactive molecules, namely platelet-rich plasma, capable of modifying the local inflammatory response, stopping the degeneration and initiating regeneration of articular cartilage, ultimately restoring joint homeostasis and health.

PI_NAMEs: ABU-AMER, YOUSEF ;ZUSTIAK, SILVIYA PETROVA (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Affect;American;Animal Model;Anti-Inflammatory Agents;Arthritis;arthropathies;articular cartilage;Autophagocytosis;Biochemical;Biological Assay;Blood Platelets;Buffers;Cartilage;cartilage degradation;cartilage regeneration;Cattle;Cell Survival;Cells;Chondrocytes;Chronic;Circular Dichroism;Clinic;Clinical Treatment;Complex;Complex Mixtures;Confocal Microscopy;Degenerative polyarthritis;Development;Disease;Dopamine;economic cost;Effectiveness;effectiveness evaluation;Encapsulated;end stage disease;Environment;fabrication;Fluorescence;Flushing;Fractionation;Friction;functional outcomes;Gait;gait examination;Gel;Gene Expression;Genes;Health;Homeostasis;Hour;Human;Hydrogels;immunotoxicity;improved;In Situ;In Vitro;in vivo evaluation;Individual;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injections;Injury;Intervention;Joint Instability;Joints;Kinetics;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;knee replacement arthroplasty;lipidomics;Lipids;Longevity;Lymphatic System;macromolecule;Measures;mechanical properties;Mechanics;Medial meniscus structure;Mediator;methacrylamide;Methacrylates;Methods;Microfluidics;Microscopy;Microspheres;Modeling;mouse model;Mus;Natural regeneration;Oral;osteochondral tissue;Outcome;Pain;Pain Measurement;palliative;particle;Pathway interactions;Patients;Performance;Periodicity;Persons;Pharmaceutical Preparations;Plasma;Play;Polyethylene Glycols;Preparation;prevent;Process;Production;Proliferating;Proteins;Proteomics;Publishing;recruit;regenerative;Replacement Arthroplasty;response;restoration;Rheology;Role;Scanning Electron Microscopy;Sclerosis;Societies;socioeconomics;Spectrum Analysis;Spinal;subchondral bone;Synovial Fluid;Synovitis;System;Systems Analysis;Techniques;Testing;Therapeutic Effect;Time;tissue regeneration;Transcript;transcriptome;transcriptome sequencing;Traumatic Arthropathy;United States

PROJECT_TITLE: Development of Injectable Super-Lubricious Microgels for Sustained Release of Platelet-Rich Plasma to Treat Post-Traumatic Osteoarthritis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Kidney Disease;Malaria;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Our proposed study in Ugandan children aims to understand how some children with severe malaria experience an abrupt loss of kidney function while sick and do not recover normal kidney function. Poor kidney health places children at higher risk of repeated kidney injury and poor health, leading to repeated hospitalizations. This study may identify medicines that can help kidneys recover from injury and lead to improved long-term recovery and health.

PI_NAMEs: CONROY, ANDREA L. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 15 year old;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;African;Age;APOL1 gene;Autoantibodies;Biological Markers;Biometry;Blood;Blood Vessels;cell regeneration;Cessation of life;Child;Child Mortality;Childhood;Chronic Kidney Failure;Clinical;clinical risk;Cognitive;Communities;Complication;Consensus;Data;design;Development;Disease Progression;disorder risk;Early Intervention;Early treatment;Endothelium;Enrollment;Etiology;experience;Fever;follow-up;Functional disorder;Genes;Genetic;genetic risk factor;Glucosephosphate Dehydrogenase Deficiency;Goals;Guidelines;healing;Health;Hemolysis;high risk;Hospitalization;immune activation;improved;Incidence;Inflammation;Injury;Injury to Kidney;insight;Intervention;Kidney;Kidney Diseases;Link;long term recovery;low and middle-income countries;Malaria;Measures;Mediating;Medicine;Nature;Nephrology;nephrotoxicity;Neurocognitive;novel;observational cohort study;Outcome;Oxidative Stress;Parasites;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Population;Positioning Attribute;Predictive Factor;Predisposition;Prevalence;prevent;Problem behavior;Process;Production;prospective;Prospective, cohort study;Recovery;Renal function;repaired;Reporting;Research;Risk;Risk Factors;Role;Serum;Severities;sex;Sickle Cell Anemia;Site;Specific qualifier value;Survivors;Testing;Time;timeline;Urine;Work

PROJECT_TITLE: Malaria associated pathogenesis of chronic kidney disease (MAP-CKD)

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

PHR: PUBLIC HEALTH RELEVANCE Ebola virus disease (EVD) is one of the world’s most feared infectious diseases and represents a growing public health threat with increasing frequency and size of outbreaks. Despite the growing number of survivors (>17,000 at present) with increased size of outbreaks and the provision of better care, little is known about the durability of the immune protection against repeat infection or what drives the clinical complications that threaten their functional capacity. We seek to better understand the protective and pathogenic effects of the EVD survivor immune system to inform approaches to the clinical management of post-EVD complications and provide insight into the immunity of EVD survivors.

PI_NAMEs: FISCHER, WILLIAM  (contact);SCHIEFFELIN, JOHN SCRIBNER;WOHL, DAVID A

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Activities of Daily Living;Acute;acute infection;Address;Africa;African;Age;Animal Model;Antibodies;Area;Attention;Autoantibodies;Autoimmune;Autoimmunity;Caring;Central Africa;Chiroptera;Clinical;clinical implementation;clinical infrastructure;Clinical Management;Clinical Research;cohort;Cohort Studies;Communicable Diseases;Country;Data;Decision Making;Democratic Republic of the Congo;Detection;Disease;Disease Outbreaks;ds-DNA;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Enrollment;Ensure;Epidemic;Evaluation;Filovirus;Frequencies;Fright;future epidemic;future outbreak;Guinea;Healthcare;Household;Human;Humoral Immunities;Immune;immune activation;Immune response;Immune system;Immunity;Immunologic Memory;Immunology;improved;Infection;Inflammation;insight;Investigation;Kinetics;Knowledge;Left;Liberia;Link;Longevity;Longitudinal cohort;Measures;Memory;Memory B-Lymphocyte;multidisciplinary;Mus;Musculoskeletal;Neurologic;neutralizing antibody;nonhuman primate;pathogen;Pathogenesis;Pathogenicity;Pathologic;personal protective equipment;Persons;Plasma;post intervention;previous outbreak;prospective;Public Health;public health relevance;Recording of previous events;recruit;Recurrence;Reporting;Research Infrastructure;response;Role;Sampling;Serology;sex;Sierra Leone;Survivors;Sushi Domain;symptomatology;Symptoms;Therapeutic Intervention;Time;Vaccination;Viral;viral outbreak;Viremia;Virus;Virus Diseases;Work

PROJECT_TITLE: The Protective and Pathologic Features of the EVD Survivor Immune System

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The proposal will determine the previously biophysical signals that control histone-modifying complexes during the normal immune response and how somatic mutations of histone-modifying enzymes reprograms B cells to undergo malignant transformation by disrupting these signals. Based on functional studies, he will identify and test the efficacy of epigenetic- targeted drugs that counteract the effect of these mutations on the epigenome and sensitize lymphomas to other targeted agents and immunotherapies.

PI_NAMEs: SINGH, ANKUR  (contact);ZHU, CHENG

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Actomyosin;Affect;Affinity;Antigens;Automobile Driving;B cell differentiation;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Binding;Biological;Biological Assay;Biomechanics;Biophysics;cancer cell;Cancerous;Cell Communication;Cell Physiology;Cell surface;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cues;Defect;Dependence;Drug Targeting;efficacy testing;Engineering;Enzymes;Epigenetic Process;epigenetic therapy;epigenome;Event;Exhibits;Extracellular Matrix;EZH2 gene;Follicular Dendritic Cells;Follicular Lymphoma;gain of function mutation;Gene Expression;Generations;genetic corepressor;Genetic Transcription;Genetically Engineered Mouse;Goals;Helper-Inducer T-Lymphocyte;histone methyltransferase;Histones;Immune;Immune response;immunoengineering;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;immunological synapse;immunological synapse formation;Immunotherapy;Impairment;large cell Diffuse non-Hodgkin's lymphoma;Ligand Binding;Ligands;lymph nodes;Lymphoid;Lymphoma;Lymphoma cell;Lymphomagenesis;Magnetism;Malignant - descriptor;Malignant Neoplasms;Mechanics;mechanotransduction;Mediating;Molecular;Mutation;Nature;novel;Pathogenesis;Patients;Phenotype;physical science;premalignant;Process;programs;Proliferating;Proteins;Reaction;receptor;receptor expression;recruit;Regulation;response;Role;Signal Induction;Signal Transduction;single molecule;Somatic Mutation;Stromal Cells;Structure of germinal center of lymph node;Surface;synergism;targeted agent;Time;TNFRSF5 gene;TNFSF5 gene;transcription factor;transcriptomics;tumor xenograft

PROJECT_TITLE: Dysregulated mechanoimmunology of epigenetics-driven lymphomas


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Diabetes;Nutrition;Obesity;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Defining roles of adipocyte Hsp47 in obesity- and cancer-associated fibrosis and adipocyte plasticity will fill critical gaps in our knowledge of the remodeling of tissue microenvironment during cancer progression. The study of Hsp47 in regulating asporin in adipocytes will reveal a novel pathway in regulating collagen deposition and alignment; and further defining roles of the Hsp47/asporin axis in cancer metastasis will identify a potential target to halt obesity-associated breast cancer progression.

PI_NAMEs: XU, REN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3-Dimensional;adipocyte differentiation;Adipocytes;Adipose tissue;asporin;Binding;Bioinformatics;Biological Assay;Blood Platelets;Breast;breast cancer metastasis;breast cancer progression;Breast Cancer Risk Factor;cancer cell;cancer recurrence;carcinogenesis;Cardiovascular Diseases;Co-Immunoprecipitations;Coculture Techniques;Collagen;Data;Deposition;Diabetes Mellitus;diet-induced obesity;digital;Epithelium;experimental study;Extracellular Matrix;Fibrosis;Funding;Genetic Transcription;High Fat Diet;Human;immune cell infiltrate;in vivo;Infiltration;Inflammation;inhibitor;insight;Knockout Mice;Knowledge;Link;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary gland development;Mammary Neoplasms;Mesenchymal;Modeling;Molecular;Molecular Chaperones;mouse model;multidisciplinary;Mus;nano-string;Nature;Neoplasm Metastasis;Non obese;novel;Obesity;Obesity associated cancer;obesity development;Pathologist;Pathway interactions;Patients;Play;Positioning Attribute;Proteins;Proteomics;recruit;Regulation;Repression;Research;Role;Scheme;second harmonic generation imaging;Signal Transduction;single-cell RNA sequencing;stemness;Surface Plasmon Resonance;survival outcome;Testing;tissue culture;Tissue Sample;Tissues;Transgenic Organisms;tumor growth;tumor progression;Tumor Tissue

PROJECT_TITLE: Roles of Hsp47 in Breast Cancer Progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Aging;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Endometriosis;Heart Disease;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Endometriosis is a common gynecologic condition that may increase a woman’s risk for cardiovascular disease later in life. Using data from the Utah Population Database and the NICHD ENDO study, we propose the largest and longest study on this topic to investigate the association between endometriosis and risk of clinical and subclinical cardiovascular disease, taking into account sociodemographic characteristics and reproductive history. Understanding these associations will help improve the identification of women who are at high risk for cardiovascular disease, which may allow for early interventions and ultimately reduce morbidity and mortality.

PI_NAMEs: FARLAND, LESLIE V;SCHLIEP, KAREN C. (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Accounting;adverse pregnancy outcome;Affect;Age;American Heart Association;Birth;Blood Banks;Brain Infarction;brain magnetic resonance imaging;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cause of Death;cerebral microbleeds;Cerebrovascular Disorders;Characteristics;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;clinical development;clinical risk;cohort;Complex;coronary calcium scoring;Coronary heart disease;Data;design;Diagnosis;Disease Marker;Disease Outcome;Dyslipidemias;Early Diagnosis;Early Intervention;Electronic Health Record;Endometriomas;endometriosis;Event;Female;follow-up;Follow-Up Studies;Glucose;Goals;Guidelines;Gynecologic;Health;high risk;Hispanic;Hyperlipidemia;Hypertension;improved;Individual;Infertility;Infiltration;Inflammation;Inflammatory;Insulin;Knowledge;Lesion;Life;Life course epidemiology;Life Cycle Stages;life span;Link;Lipids;Longitudinal Studies;Measures;Mediating;Medical;Medical Electronics;Metabolic syndrome;middle age;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patients;Phenotype;Play;Population;Population Database;Population Heterogeneity;Predisposition;Prevention;Recontacts;Recording of previous events;Records;reproductive;Reproductive History;reproductive system disorder;Research;Risk;Risk Factors;risk stratification;Role;Sample Size;Scanning;screening;sociodemographics;Time;Utah;Visit;Vital Statistics;Vital Status;white matter;Woman;woman health professional;Women's Health;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Endometriosis Diagnosis and Subtypes, Reproductive History, and Cardiovascular Disease

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Phosphate impacts nearly every aspect of human biology, but how our body senses circulating phosphate levels is unknown. The recent finding that the kidney releases a molecule that regulates phosphate levels provides an important clue that phosphate sensing may occur in the kidney. This proposal will study how and why phosphate specifically activates this process in the kidney, with the goal to enhance our fundamental understanding of human physiology and to provide new treatment targets in kidney, bone, and vascular disease.

PI_NAMEs: RHEE, EUGENE P. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acute;alpha-glycerophosphoric acid;Animals;Attenuated;Biochemical;Biology;Blood;body sense;bone;Bone Diseases;bone health;bone loss;cardiovascular health;Cells;Chronic;Collaborations;Coupled;Data;Diet;dietary;Disease;Energy Metabolism;Enzymes;experimental study;Fasting;fibroblast growth factor 23;fluorodeoxyglucose;follow-up;Gluconeogenesis;Glycerol-3-Phosphate Dehydrogenase;Glycolysis;Goals;Homeostasis;Hormones;Human;Human Biology;human disease;Hypoparathyroidism;In Vitro;in vivo;inhibitor;inorganic phosphate;Intestines;Isotope Labeling;Kidney;Kidney Diseases;kidney metabolism;knockout animal;Knowledge;Laboratories;Life;Lipids;Magnetic Resonance Imaging;Mediating;Metabolic acidosis;metabolic imaging;Metabolism;metabolomics;Mus;novel;Nucleic Acids;Oral;Organ;pharmacologic;Physiologic calcification;Physiological;Physiology;Play;Positron-Emission Tomography;prevent;Process;Production;Proximal Kidney Tubules;Reaction;renal ischemia;Role;sensor;Signal Transduction;Sodium;sodium-phosphate cotransporter proteins;Specificity;Stimulus;symporter;System;Testing;Tissues;Triglycerides;Tubular formation;uptake;Vascular calcification;Vascular Diseases

PROJECT_TITLE: Kidney Glycolysis as the Mammalian Phosphate Sensor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Kidney Disease;Neurodegenerative;Precision Medicine

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Cognitive impairment, a clinical symptom of Alzheimer’s Disease and Related Dementias (ADRD) is common among adults living with CKD; however, this condition is understudied compared with other clinical endpoints associated with CKD. Prior work has shown that urine biomarkers of kidney tubule injury and dysfunction are associated with worse cognitive function independent of eGFR and ACR, however, the relationship is likely more complex than what can be identified through a few targeted biomarkers. The objectives of this proposal are to use large-scale proteomics to 1) identify protein clusters and biological pathways that associate with CI among adults with CKD in the Chronic Renal Insufficiency Cohort (CRIC), 2) identify a parsimonious panel of proteins that predict CI by testing penalized variable selection methods in adults with CKD in CRIC, and 3) identify whether aims 1 and 2 externally validate using the Cardiovascular Health Study with the ultimate long- term goal of detecting potential drug targets.

PI_NAMEs: MILLER, LINDSAY M. (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Adhesions;Adult;Albumins;Albuminuria;Alzheimer's disease related dementia;Biological;Biological Markers;biomarker panel;Biometry;blood pressure intervention;Blood Vessels;Body System;California;Cardiovascular Diseases;cardiovascular health;career;career development;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinical;clinical practice;clinical predictors;Cognition;cognitive function;cohort;Cohort Studies;Collaborations;Complex;Creatinine;Cytokine Signaling;Data;Development;Diagnosis;Diagnostic;Discrimination;Disease;disease heterogeneity;Doctor of Medicine;Doctor of Philosophy;Drug Targeting;Educational workshop;Elasticity;Elderly;End stage renal failure;Functional disorder;Glomerular Filtration Rate;Goals;Grant;Health;Heterogeneity;high risk;Hypertension;Immunity;Impaired cognition;Individual;Inflammation;Injury;insight;Intervention;Intervention Trial;Investigation;Kidney;Kidney Diseases;Laboratories;Link;Medicine;Mentors;Mentorship;Methods;mild cognitive impairment;Monitor;multidisciplinary;Myocardial Infarction;Nature;Nephrology;Neuropsychology;novel;novel strategies;novel therapeutics;older adult;Organ;Oxidative Stress;Participant;Pathology;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Plasma;Population;predictive panel;prevent;protein biomarkers;Protein Dynamics;Proteins;Proteome;Proteomics;Renal tubule structure;Research;Research Personnel;Risk;Risk Assessment;San Francisco;screening;Sensitivity and Specificity;skills;Symptoms;targeted biomarker;Technology;Testing;Time;Training;treatment response;Troponin;Tubular formation;Universities;urinary;Urine;Work;Writing

PROJECT_TITLE: Leveraging Proteomics to Understand the Link Between Chronic Kidney Disease and Cognitive Impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


PHR: Project Narrative The parasympathetic and sympathetic arms of the autonomic nervous system play critical roles in regulating energy storage and expenditure. This proposed project aims to understand the mechanisms by which the adipose hormone leptin regulates plasticity in the autonomic innervation of organs involved in energy balance; specifically, in adipose tissue and the pancreas, by building on our recent discovery that leptin regulates sympathetic innervation plasticity in fat. Understanding these mechanisms will enable the identification of targets that can directly modulate innervation and hence the energy regulating function of these organs, forming a foundation for new therapies to treat obesity and diabetes.

PI_NAMEs: LOH, HUAI JIN KEN LEON  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Adipose tissue;Adult;Affect;American;Architecture;arm;autocrine;Automobile Driving;Autonomic nervous system;Axon;Biological Assay;Biotin;Biotinylation;blood glucose regulation;Brain;Brain-Derived Neurotrophic Factor;Brown Fat;Cell Adhesion Molecules;cell type;Cells;Chronic;Coculture Techniques;Communication;Defect;density;Diabetes Mellitus;diet-induced obesity;differential expression;Disease;Dissection;energy balance;Energy Metabolism;Expenditure;Fatty acid glycerol esters;Feedback;Foundations;Functional disorder;Gene Expression Profiling;Glucagon;Grant;Homeostasis;Hormone secretion;Hormones;Hypothalamic structure;in vivo;in vivo calcium imaging;Individual;Insulin;Intake;Islet Cell;Islets of Langerhans;Label;Lead;Leptin;Leptin deficiency;Ligase;Light;Lipolysis;Long-Term Effects;loss of function;Maintenance;Mass Spectrum Analysis;Mediating;Mentors;Metabolic;Metabolic Diseases;Methods;Microscopy;Molecular;Nature;Nerve;nerve supply;Nervous System;neural;neural circuit;Neurons;novel therapeutics;Nutrient availability;Obese Mice;Obesity;Organ;Pancreas;Pancreatic Hormones;Pancreatitis;Pattern;Phase;Play;Population;prenatal;Process;Proteins;Proteomics;Public Health;reduced food intake;Regulation;reinnervation;Resistance;response;restoration;Role;Signal Transduction;Surface;Sympathetic Ganglia;Sympathetic Nervous System;Testing;Therapeutic;Thermogenesis;Tissues;tool;Translating;uptake;Visualization;Work

PROJECT_TITLE: Mechanisms underlying autonomic innervation plasticity in regulating energy balance


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Longitudinal lung function in asthmatics is a critical risk factor for future exacerbations, chronic airway obstruction, morbidity and mortality. MicroRNA sequencing, metabolome-wide profiling, full exome sequencing, and genome-wide genotyping provide ideal data to increase our understanding of lung function decline from DNA variant to transcriptomic regulation to metabolic alterations to disease pathophysiology. Capitalizing on the rich resources available via the Mass General Brigham Biobank, we will create a cohort of asthmatics with multi-omic data to identify and validate integrative-omic blood biomarkers of lung function trajectory that inform on the fundamental underlying biology.

PI_NAMEs: LASKY-SU, JESSICA A;MCGEACHIE, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Adult;Affect;Age;airway remodeling;Anabolism;Asthma;asthmatic;biobank;Biological;Biological Markers;Biology;biomarker signature;Blood;Childhood;Chronic;chronic airflow obstruction;Classification;Clinical;clinical translation;clinically actionable;clinically relevant;cohort;Complication;Computerized Medical Record;Data;Deterioration;Development;Diagnosis;Disease;DNA;early detection biomarkers;Eicosanoids;Evaluation;Exhibits;exome sequencing;Functional disorder;Future;Genes;Genetic;genome wide association study;genome-wide;Genomics;Genotype;global health;Health Care Costs;health care service utilization;improved;Individual;Inflammatory;Infrastructure;innovation;insight;late life;Life;Longitudinal Studies;Lung;Measurement;Measures;Metabolic;metabolome;metabolomics;MicroRNAs;miRNA expression profiling;Monitor;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;novel;Obstruction;Outcome;Participant;Patients;Pattern;personalized medicine;Phenotype;phenotypic data;Physicians;Physiological;Physiology;Play;prevent;prognostication;progression risk;pulmonary function;pulmonary function decline;Regulation;Resources;Risk;Risk Factors;Role;sample collection;Sampling;Serum;Sphingolipids;Spirometry;Structure;Systems Biology;Techniques;therapeutic target;Time;transcriptomics;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Omic Determinants of Longitudinal Lung Function in Asthma

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The combined prevalence of overweight and obesity in youth with type 1 diabetes mellitus (T1DM) is now greater than the prevalence of combined overweight and obesity in youth of the general population, and increased weight in youth with T1DM increases risk factors for cardiovascular health problems. This K23 project will adapt an established behavioral weight management intervention for adolescents with overweight/obesity for a T1DM population. Study results and the Candidate’s training plan will inform a larger efficacy trial evaluating this novel evidence-based behavioral weight management intervention for adolescents with T1DM and overweight/obesity and will launch the Candidate’s career as an independent clinical investigator.

PI_NAMEs: WARNICK, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent health;Age;age group;Attention;Award;Behavior;Behavior Control;behavior test;Behavior Therapy;Behavioral;behavioral health;Behavioral trial;Blood Glucose;Body mass index;Body Weight decreased;Calories;cardiometabolic risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Caregivers;Childhood;Clinical Investigator;Clinical Research;comorbidity;comparative;comparison control;Consumption;Dangerous Behavior;Data;Data Analyses;design;Development;Diabetes Mellitus;Diet;Disease Management;disorder prevention;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;efficacy testing;efficacy trial;Endocrinologist;Ensure;Event;evidence base;Evidence based intervention;Exercise;experience;Fright;General Population;Glycosylated hemoglobin A;Goals;Grain;Guidelines;Health;high risk;Hunger;Hypoglycemia;improved;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Intervention;intervention refinement;Intervention Trial;Interview;life span;Measures;medical appointment;Mentors;Mentorship;Mission;Modeling;Morbidity - disease rate;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obesity;obesity in children;Outcome;Overweight;Participant;Patient Self-Report;Patients;Phase;Phase Ib Trial;pilot test;Population;Populations at Risk;post intervention;Prevalence;prevent;primary outcome;programs;Puberty;public health intervention;purge;Qualifying;Randomized, Controlled Trials;Regulation;Research;Review Literature;Risk;secondary outcome;sex;skills;Surveys;Testing;therapy development;Thinking;Time;Training;trial design;usual care arm;Weight;Weight Gain;Weight maintenance regimen;Work;Youth

PROJECT_TITLE: Adapting an Adolescent Weight Management Program for a Type 1 Diabetes Population

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Sphingolipids are a class of fatty molecules that have been thought to serve primarily as structural molecules in formation of cell membranes. Our work identified specific functions for individual sphingolipids, thus leading to their appreciation as `bioactive molecules', and in this proposal we focus on key enzymes of sphingolipid metabolism with important functions in cell stress responses. In the process of defining these pathways and mechanisms, we tackle some of the most recalcitrant problems in understanding these pathways, and we provide the foundations that allow many investigators to probe the health and therapeutic significance of the enzymes and pathways we are defining.

PI_NAMEs: HANNUN, YUSUF AWNI (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: biological adaptation to stress;Cell membrane;Cell Nucleus;Cellular Stress;Ceramides;Data;DNA Damage;Enzymes;Foundations;Goals;Health;human disease;Individual;Lipids;Malignant Neoplasms;Mediating;Metabolism;Nuclear;Pathway interactions;place fields;Process;Protein phosphatase;Regulation;Research Personnel;Research Proposals;response;Role;Solid;Sphingolipids;Sphingomyelinase;Stimulus;Structure;Therapeutic;tool;Transducers;Work;Yeasts

PROJECT_TITLE: Neutral Sphingomyelinases and Bioactive Ceramides

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative The objective of the program is to provide a highly enriched, multi-disciplinary training experience in biotechnology for predoctoral students from a broad variety of departments across the university. Program components, which include coursework, mentored research experiences, and industry engagement, provide a unique mechanism for training talented students who will become the next generation of global biotechnology innovators and leaders.

PI_NAMEs: COCHRAN, JENNIFER R (contact);YANG, FAN

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Biotechnology;Training Programs

PROJECT_TITLE: Graduate Training Program in Biotechnology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]