NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Substance Misuse

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This study will investigate the mechanisms of alcohol-mediated brain inflammation and activation of a protein complex called the inflammasome in the development and progression of Alzheimer’s disease (AD). We will identify critical molecules contributing to exacerbated AD- associated cognitive impairments after excessive chronic alcohol use. Our study will provide new insights on the role of inflammasomes in alcohol-mediated neuroinflammation and AD progression.

PI_NAMEs: GOLENBOCK, DOUGLAS T;SZABO, GYONGYI  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Acceleration;Affect;Age Months;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;Alcohols;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;anakinra;antagonist;APP-PS1;Behavioral;Biochemical;Biology;Brain;Brain Injuries;brain tissue;CASP1 gene;Chronic;chronic alcohol ingestion;Cognitive;cytokine;Dementia;Deposition;Development;Diet;Disease Progression;drinking water;Elements;Encephalitis;Enzyme-Linked Immunosorbent Assay;epidemiologic data;experimental study;feeding;Gene Expression;Heavy Drinking;Immune signaling;Impaired cognition;Inflammasome;Inflammation;Inflammatory;insight;Interleukin-1;Interleukin-1 Receptors;Interruption;Intervention;Long-Term Effects;Long-Term Potentiation;Mediating;Messenger RNA;Microglia;Modeling;Molecular;Morphology;mouse model;Multiprotein Complexes;Mus;neuroinflammation;Neuronal Dysfunction;Neurons;novel;Organ;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;pharmacologic;Play;pre-clinical;Production;protein complex;Proteins;Reporting;Research;Role;Signal Pathway;Signal Transduction;tau Proteins;tau-1;Testing;therapeutic target;Vertebral column;Water;Western Blotting

PROJECT_TITLE: Inflammasome activation in modulation of Alzheimer's Disease by alcohol


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE While antibody-mediated lymphocyte depletion is commonly used to eliminate donor-reactive T cells in transplant recipients, its impact on long-term transplant survival remains controversial. The proposed studies will investigate how inflammatory pathways triggered by allograft transplantation drive rapid reconstitution of pathogenic memory T cells. Based on the gained mechanistic insights, we will test several clinically relevant approaches for prolonging heart allograft survival in recipients treated with lymphoablation.

PI_NAMEs: VALUJSKIKH, ANNA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Address;Alloantigen;allograft rejection;Allografting;analog;Antibodies;Antithymoglobulin;B-Cell Activation;B-Cell Development;B-Lymphocytes;C Type Lectin Receptors;C-Type Lectins;CDW52 gene;Cell Compartmentation;Clinical;clinically relevant;cytokine;Data;design;efficacy testing;Equilibrium;Follow-Up Studies;Funding;Gene Expression Profiling;Genetic;Goals;graft function;heart allograft;high risk;Immunosuppression;improved;Inflammation;Inflammatory;insight;Interleukin-1 beta;Interleukin-6;Ischemia;kidney allograft;Lymphocyte Depletion;Macrophage;Mediating;Mediator;memory CD4 T lymphocyte;Modeling;Monoclonal Antibodies;Mus;Neoadjuvant Therapy;Organ;organ transplant recipient;Oryctolagus cuniculus;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptide/MHC Complex;Play;post-transplant;Prevention;Process;Production;Proliferating;reconstitution;Recovery;Reperfusion Injury;Reporting;Resistance;Role;sensor;Signal Transduction;Solid;Stem cell transplant;Sum;T cell reconstitution;T cell therapy;T memory cell;T-Cell Depletion;T-Cell Proliferation;T-Lymphocyte;Testing;Time;Tissue Grafts;tissue injury;TLR4 gene;TNFRSF5 gene;TNFSF5 gene;Transplant Recipients;Transplantation;transplantation therapy;Whole-Body Irradiation

PROJECT_TITLE: Designing induction therapies to target memory T cells in high risk recipients

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative As a major component of bacterial cell envelope, surface proteins of Gram-positive bacteria are key molecules in mediating bacterial interactions with the environment. The primary focus of this project is to understand the spatiotemporal regulation of surface protein biogenesis in Staphylococcus aureus, a human commensal bacterium and a leading cause of various infections. As surface proteins and cell envelope components are essential for bacterial virulence and fitness, the outcome of this project will not only reveal novel mechanisms of bacterial cell envelope assembly, but also provide potential new targets for new antimicrobials and vaccines.

PI_NAMEs: YU, WENQI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: antimicrobial;Bacteria;Biogenesis;Cell Cycle;Cell division;cell envelope;Cell membrane;Cell Physiology;Cell Wall;Cells;commensal bacteria;Complex;Deposition;Environment;fitness;Foundations;Gram-Positive Bacteria;Growth;Human;Infection;insight;lipoteichoic acid;Mediating;Membrane Proteins;Methods;Microscopy;model organism;Modeling;novel;Outcome;Peptide Signal Sequences;Peptidoglycan;programs;Proteins;Regulation;Research;Research Project Grants;sortase;spatiotemporal;Staphylococcus aureus;Structure;Teichoic Acids;Time;Vaccines;Virulence

PROJECT_TITLE: Spatiotemporal regulation of bacterial cell envelope assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Cell fate engineering, for example the directed differentiation of pluripotent stem cells or the direct conversion among somatic cell types, holds great promise to improve disease modeling, drug screening, and to lead to regenerative medicine therapies. However, our ability to engineering cell fate with fidelity has been impeded by an incomplete understanding of the biological networks that govern development. In this work, I propose to address this problem through a combination of algorithm development and data generation, with an emphasis on cell types related to the synovial joint.

PI_NAMEs: CAHAN, PATRICK  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Adopted;algorithm development;Binding Sites;Biological;Calibration;cell type;Cells;Chondrocytes;Chromatin;computerized tools;Computing Methodologies;Data;Development;differentiation protocol;directed differentiation;disease model;Drug Screening;Engineering;follow-up;Funding;gastrulation;Generations;Genes;Genetic Transcription;Goals;improved;In Vitro;Intention;invention;meetings;Mesoderm;novel;Orphan;Outcome Assessment;pluripotent stem cell differentiation;Pluripotent Stem Cells;Recipe;Regenerative Medicine;Resolution;Signal Pathway;single-cell RNA sequencing;Somatic Cell;Synovial joint;Technology;Testing;tool;transcription factor;Work

PROJECT_TITLE: From intra to intercellular regulatory networks that define cell type identity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it has significant promise to increase human papillomavirus (HPV) vaccination rates among 9- to 12-year-olds, and therefore, reduce the HPV-related cancer disparity in rural areas. The project builds upon existing evidence of improving clinicians’ recommendations and increasing parents’ motivations while adding strategies that address common social determinants that inhibit parents’ ability to have their child receive the HPV vaccine. The proposed research is relevant to NIH’s mission to prevent cancer in the United States within all demographics including rural populations.

PI_NAMEs: STARAS, STEPHANIE A S (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: 12 year old;15 year old;Academy;Address;Affect;Age;Agriculture;American;American Cancer Society;Area Health Education Centers;arm;Behavior;biological sex;boys;Cancer Center;cancer health disparity;cancer prevention;Child;Clinic;Clinic Visits;Clinical;Clinical Research;Clinical Sciences;Cluster randomized trial;Code;Communities;community advisory board;community engagement;cost effective;cost effectiveness;cost-effectiveness evaluation;County;demographics;Disparate;Disparity;Dose;Effectiveness;effectiveness evaluation;Ethnic Origin;evidence base;experience;Florida;Food;girls;Health;health care availability;Healthcare;Home;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;implementation strategy;improved;Incidence;innovation;Insurance;Intervention;Licensing;Malignant Neoplasms;Measures;Misinformation;Mission;Modeling;Motivation;motivational enhancement therapy;Parents;Patients;Pediatrics;Physicians;prevent;Prevention;primary outcome;programs;Public Health;Race;Randomized;Recommendation;Research;Resources;Rural;rural area;Rural Community;Rural Health;rural health network;Rural Population;rural setting;Schedule;Science;Series;social determinants;social vulnerability;success;Telephone;Training;Translational Research;Transportation;transportation access;United States;United States National Institutes of Health;Universities;urban area;Vaccination

PROJECT_TITLE: ReMARk: A multi-level strategy to address disparities in rural HPV-related cancer prevention


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: Project Narrative The proposed data, evaluation, and coordinating center (DECC) for the Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) program will support the implementation and evaluation of multilevel and culturally tailored outreach and education interventions aiming to increase the accrual of underrepresented populations in clinical trials.

PI_NAMEs: FREIMUTH, ROBERT RICHARD;LE-RADEMACHER, JENNIFER G.;ODEDINA, FOLAKEMI T (contact)

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Administrative Efficiency;Adopted;Affect;Award;Benchmarking;black men;cancer care;cancer health disparity;Caring;Clinical Data;Clinical Trials;Clinical Trials Network;Collaborations;Common Data Element;Communication;Communities;Consensus;Data;Data Analytics;Data Collection;Data Coordinating Center;data exchange;data harmonization;data management;Data Pooling;Data Science;data sharing;Dedications;Department of Defense;Development;Discipline;Education and Outreach;Educational Intervention;Ethics;Evaluation;evidence base;Fostering;Generations;Goals;Grant;Health;health disparity;health equity;Human;implementation strategy;Incidence;Infrastructure;Institution;interoperability;Intervention;Leadership;Learning;Logistics;Malignant Neoplasms;Manuscripts;Measures;meetings;member;Methods;Mission;mortality;National Center for Advancing Translational Sciences;Oncology;operation;Outcome;Policies;Population;Positioning Attribute;privacy preservation;Procedures;Process;Program Evaluation;programs;Protocols documentation;Publications;Recommendation;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Support;Resources;Science;Secure;Services;Site;social media;Standardization;statistics;Structure;Terminology;tool;Underrepresented Populations;web portal;Work

PROJECT_TITLE: The Data, Evaluation, and Coordination Center (DECC) for Connecting Underrepresented Populations to Clinical Trials (CUSP2CT)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Corneal endothelial dystrophies are common eye conditions that cause bilateral vision loss and an effective non-surgical treatment for these diseases remains a major unmet clinical challenge. This research proposal opens a new field of investigation into the correction of protein misfolding defects as a therapeutic strategy for corneal endothelial dystrophies.

PI_NAMEs: CHAN, MATILDA F (contact);GESTWICKI, JASON E

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;analog;Anaphylaxis;Apoptosis;Bilateral;Binding;Biological Assay;Blindness;candidate identification;Carrier Proteins;Cell Physiology;Cell Survival;Cells;chemical genetics;Chemicals;Clinical;clinical candidate;Clustered Regularly Interspaced Short Palindromic Repeats;Confocal Microscopy;congenital cataract;Cornea;Corneal Diseases;Corneal dystrophy;Corneal Endothelium;CRISPR interference;Crystallins;cytotoxic;cytotoxicity;Data;Defect;Disease;early onset;Endothelium;Equilibrium;experimental study;Eye;Eye diseases;Free Energy;Fuchs' Endothelial Dystrophy;Functional disorder;functional gain;functional restoration;Genes;Genetic Screening;genome-wide;Glafenine;Goals;high throughput screening;high throughput technology;improved;In Vitro;in vitro Assay;Inflammatory;Inherited;insight;Investigation;Keratoplasty;Kidney;Lead;Length;Libraries;Link;loss of function;Mass Spectrum Analysis;Measurement;Measures;Medical;Methods;Microscopy;misfolded protein;mutant;Mutation;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;Open Reading Frames;Osmosis;Outcome;Patients;Phenotype;Point Mutation;preclinical development;Process;protein folding;protein function;protein misfolding;Proteins;Quality Control;repaired;Research;Research Proposals;response;screening;Series;sight restoration;Site;small molecule;small molecule libraries;Structure-Activity Relationship;Surface Plasmon Resonance;Syndrome;Testing;Therapeutic;Toxic effect;Toxicity Tests;trafficking;Visual impairment;α-Crystallins

PROJECT_TITLE: Analysis of chemical modulators for corneal endothelial dystrophies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neoplasms with increasing incidence and ill-defined pathobiology. The goals of this proposal are (1) to develop and validate a clinically available assay for the prognostic stratification of NF-PanNETs, (2) to define the nanoscale chromatin changes in the stepwise progression of NF-PanNETs to metastatic disease and (3) to identify drivers and molecular pathways in the metastatic progression of NF-PanNETs.

PI_NAMEs: SINGHI, AATUR DILIP (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Abdomen;Affect;ARID1A gene;ATRX gene;Autopsy;Behavior;Biological Assay;Biological Markers;cancer cell;Cells;Cessation of life;Chromatin;chromatin remodeling;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;clinical implementation;clinically significant;cohort;Common Neoplasm;DAXX gene;Detection;Development;Disease;Disease-Free Survival;Distant Metastasis;DNA Sequence Alteration;Epigenetic Process;epigenomics;Excision;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;High Prevalence;Histone H3.3;Histones;imaging modality;improved;Incidence;Individual;Indolent;innovation;insight;Institution;International;Islet Cell Tumor;Maintenance;Methods;Molecular;Molecular Chaperones;Mutation;nanoscale;Neoplasm Metastasis;Neoplasms;neoplastic cell;novel;Operative Surgical Procedures;overtreatment;pancreatic neoplasm;Pathogenesis;Pathway interactions;patient biomarkers;patient prognosis;patient stratification;patient subsets;Patients;Pattern;Play;Postoperative Period;Predisposition;prognostic;prognostic assays;Prognostic Marker;prognostic performance;prognostic significance;prospective;Prospective Studies;Proteins;Proteomics;radiological imaging;reconstitution;Recurrence;Regulation;Regulator Genes;Reporting;research clinical testing;response;Retrospective Studies;Role;Sampling;Specimen;Staging System;Stratification;superresolution imaging;System;Telomerase;telomere;Testing;transcriptome sequencing;tumor;tumor progression;United States;Validation;validation studies

PROJECT_TITLE: The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: The COVID-19 pandemic led to profound changes in prenatal care delivery, including the implementation of hybrid prenatal care models (reduced visit schedules and telemedicine) which have since been recognized as new national consensus recommendations for prenatal care. For hybrid prenatal care models to be adopted across clinical settings, it is critically important to evaluate their effect on clinical outcomes, including patients’ and providers’ experience with these models, prior to widespread implementation. This mixed-methods proposal leverages rigorous econometric analyses, detailed electronic health record data, and rich qualitative interviews with patients and providers, to understand how hybrid prenatal care models will affect average-risk patients and patients from key marginalized groups: low-income, Black and rural patients

PI_NAMEs: PEAHL, ALEX  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Accident and Emergency department;Admission activity;Adopted;Adoption;adverse outcome;adverse pregnancy outcome;Affect;American College of Obstetricians and Gynecologists;barrier to care;Birth;Birth Rate;black patient;Black race;care delivery;care outcomes;Caring;Cesarean section;Clinical;Consensus;COVID-19;COVID-19 pandemic;Data;design;Disparity;econometrics;Electronic Health Record;Emergency department visit;Ensure;Equity;Evaluation;experience;Expert Opinion;Gestational Diabetes;Goals;Guidelines;Gynecologist;Health;Health Services Accessibility;high risk;Hybrids;improved;Incidence;Indiana;innovation;Institution;intervention effect;Interview;Investigation;Knowledge;Low income;marginalization;marginalized population;maternal outcome;Medical;Medical center;Medical Liabilities;Medicine;Methods;Michigan;Modeling;Neonatal;Neonatal Intensive Care Units;neonatal outcome;Outcome;Outpatients;overtreatment;pandemic disease;patient population;Patients;Pattern;Persons;Population;Postpartum Depression;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnant;Premature Birth;prenatal;Prenatal care;Provider;provider factors;Recommendation;Research;Research Design;Risk;Risk Factors;rural patients;Sampling;Schedule;service utilization;Services;Site;Small for Gestational Age Infant;Strategic Planning;Subgroup;tailored health care;Telemedicine;Telephone;Time;traditional care;Transportation;United States;United States National Institutes of Health;Universities;Visit;Woman;Work

PROJECT_TITLE: Adapting COVID-19 Prenatal Care Innovations for Patients At Risk of Adverse Pregnancy Outcomes: a Mixed Methods Study of the Plan for Appropriate Tailored Healthcare in Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patterned changes to 3D-genome organization and chromatin state prove essential for normal gene expression, whose dysregulation is a causal determinant of many neurodevelopmental diseases. Using mouse olfactory sensory neurons as a model system, we devised a single-cell genomic strategy to understand how neurons achieve the nuclear architecture and chromatin modifications necessary to support normal gene expression. We aim to characterize structural and biochemical features that distinguish genes in active and inactive states, while delineating a molecular mechanism for how these features arise, to clarify parameters for gene regulation relevant to nervous system function in health and disease.

PI_NAMEs: POURMORADY, ARIEL DAVID (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 3-Dimensional;Alleles;Architecture;Automobile Driving;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biology;Cell Nucleus;Cells;Chromatin;chromatin modification;chromosome conformation capture;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Constitution;Data;Development;Disease;DNA;Elements;Enhancers;Event;Exhibits;experimental study;Feedback;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Pool;Genes;genetic approach;genetic manipulation;Genetic Transcription;Genome;genome analysis;genome-wide analysis;Genomic approach;genomic data;Genomics;Greek;Health;Heterochromatin;Hi-C;Histones;Island;Link;Liquid substance;Measures;Messenger RNA;Methods;Modification;Molecular;morphogens;mouse model;Mus;Mutate;Nervous System;Nervous System Physiology;Neurodevelopmental Disorder;Neurons;Nuclear;Odorant Receptors;Olfactory Epithelium;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Pathway interactions;Pattern;Population Analysis;Process;Production;Property;Proteins;receptive field;receptor;receptor expression;Receptor Gene;recruit;Research;Resolution;RNA;Role;Scheme;Shapes;Signal Transduction;single cell ATAC-seq;single cell genomics;stem cells;structural determinants;Structure;Testing;transcription factor

PROJECT_TITLE: Deciphering mechanisms for olfactory receptor choice in single cells


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed work leverages implementation science methods to develop, pilot and cost an effective and sustainable facility level-based implementation and dissemination strategy for single visit screen and treat with thermal ablation (SVA-SAT+TA) approach for cervical cancer prevention and inform national program scale up.

PI_NAMEs: GIMBEL, SARAH ODELL;MUGO, NELLY RWAMBA (contact)

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Ablation;Acetic Acids;Adoption;Aftercare;Age;aged;budget impact;Cancer Burden;Cancer Control;Cancer Etiology;Cancer Model;cancer prevention;cervical cancer prevention;Cessation of life;Charge;Client;Clinic;Clinical effectiveness;Cold Therapy;Collaborations;cost;cost comparison;cost effectiveness;cost estimate;County;Cytology;Data;Decision Analysis;Devices;Dissemination and Implementation;dissemination strategy;Eastern Africa;Educational workshop;effective intervention;Effectiveness;Electricity;Eligibility Determination;Equipment;Equipment Failure;Evaluation;Evidence based intervention;experience;Feedback;follow-up;Gases;Goals;Head;Health;Heterogeneity;Human Papillomavirus;implementation intervention;implementation science;implementation strategy;improved;Incidence;Intervention;intervention effect;Interview;Kenya;Learning;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Methods;microcosting;Modeling;multidisciplinary;Nurses;opportunity cost;patient population;Patients;Policies;Population;population based;portability;premalignant;prevention service;Process Measure;programs;prospective;Provider;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reproductive Health;Resource-limited setting;routine care;rural setting;Safety;scale up;Science;screening;secondary analysis;Services;supply chain;System;Techniques;Technology;Testing;Thermal Ablation Therapy;Training;treatment duration;Update;uptake;Visit;Visual;Woman;Women's mortality;women's treatment;Work;World Health Organization;Zambia

PROJECT_TITLE: Towards Cervical cancer elimination: Implementation and scale-up of a single-visit, screen-and-treat approach with thermal ablation for sustainable cervical cancer prevention services in Kenya

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Prevention

ORG_CITY: ATHENS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Osteoarthritis (OA) affects millions of people in the United States annually and leads to long-term disability. The proposed project seeks to examine an understudied mechanism of poor knee joint health development that will drive the advancement of OA prevention strategies to benefit the public health. The proposed project is relevant to NIH’s mission because it contributes high-quality, foundational knowledge in clinical research to promote long- term health and reduce disability in individuals at risk for OA.

PI_NAMEs: LISEE, CAROLINE M (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Animal Model;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;arm;Biology;Biomechanics;career;career development;Cartilage;Clinical Research;clinical trial implementation;Clinical Trials;Collagen;Cross-Sectional Studies;Data;Degenerative polyarthritis;density;Development;disability;disorder prevention;efficacy evaluation;Frequencies;Funding;Future;Goals;Health;health assessment;high risk;high risk population;human subject;improved;in vivo;Individual;innovation;Intervention;joint loading;Joints;K-Series Research Career Programs;Knee joint;Knee Osteoarthritis;Knowledge;Laboratories;Limb structure;Link;Long term disability;Magnetic Resonance Imaging;Measures;mechanical load;Mechanics;Medial;Mentors;Mission;novel;Observational Study;Participant;Persons;Physical activity;physical inactivity;Pilot Projects;pilot test;Population;Pre-Post Tests;Prevention;Prevention Research;Prevention strategy;preventive intervention;Principal Investigator;Productivity;Proteoglycan;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;reconstruction;Reconstructive Surgical Procedures;Relaxation;Research;Research Design;Research Personnel;resilience;response;Rest;Risk;Risk Factors;risk mitigation;Risk Reduction;Series;skill acquisition;skills;Sports Medicine;Standardization;Surrogate Endpoint;Testing;theories;Thick;Time;Training;Traumatic Arthropathy;United States;United States National Institutes of Health;Walking

PROJECT_TITLE: Steps Towards OA Prevention

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Sleep Research;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE Air pollution is the world’s most important environmental risk factor that contributes more to global morbidity and mortality than tuberculosis, malaria, AIDS, wars and famine combined. In this transformative project, we provide compelling new data on air pollution as a disruptor of endogenous biologic “circadian” rhythms. Through careful studies in animals and humans and large cohorts, we will evaluate the impact of exposure and personalized interventions on heart and metabolic health. Our results will provide compelling new data to prevent the health problems caused by air pollution exposure globally.

PI_NAMEs: RAJAGOPALAN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Air;Air Pollution;Animals;Biological;Cardiometabolic Disease;cardiometabolic risk;cardiovascular risk factor;Cardiovascular system;circadian;Circadian Dysregulation;Circadian Rhythms;cohort;Data;Disease;Environmental Risk Factor;Epigenetic Process;Famines;genome wide association study;Goals;Health;Health Policy;Heart;Human;Influentials;innovation;Insulin Resistance;Intervention;Intervention Trial;Light;Link;Malaria;Mediating;Mediator;Mendelian randomization;Metabolic;Metabolic dysfunction;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;Particulate Matter;Pathway interactions;personalized intervention;personalized strategies;prevent;programs;protective effect;Public Health;Research;Risk;Sleep;success;translational clinical trial;translational framework;Translational Research;Tuberculosis;Vulnerable Populations;War

PROJECT_TITLE: (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air Pollution


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Public Health Statement: Embryonic stem cells hold great promise for regenerative medicine because they possess unlimited self-renewal potential and the remarkable ability to differentiate into any cell type. To precisely control differentiation of embryonic stem cells for regenerative medicine, we study molecular mechanisms linking division and differentiation of embryonic stem cells. Insights from our studies will advance our understanding of the basic biology of differentiation of pluripotent cells, which has immediate implications for robust differentiation of embryonic stem cells into therapeutic cell types for regenerative medicine purposes.

PI_NAMEs: SHARIATI, ALI  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Automobile Driving;Biological;Biology;California;Cell Cycle;cell type;Cells;chemical genetics;Collaborations;Complex;CRISPR screen;embryonic stem cell;Engineering;experimental study;Feedback;Genetic Engineering;Genetic Transcription;Goals;insight;Label;Laboratories;Link;Maintenance;MEKs;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Molecular;novel;novel strategies;Outcome;Pathway interactions;phosphoproteomics;Phosphotransferases;pluripotency;Pluripotent Stem Cells;Process;professor;Public Health;Qi;regeneration potential;Regenerative Medicine;Reproducibility;response;self-renewal;Testing;Therapeutic;Universities

PROJECT_TITLE: Molecular feedback between cell division cycle and differentiation in pluripotent stem cells


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: This project seeks to develop and share a new curriculum and set of assessment tools to enable effective and efficient educational experiences for undergraduate engineering students in needs-identification and needs characterization--the first two steps in the Biodesign Process for health technology innovation. With the convergence of a rapidly changing landscape in healthcare, and the incredibly fast pace of technological change, today’s young innovators face unprecedented challenges. Yet, a combination of patient-focused approach and needs-first innovation skills can unlock unprecedented capacities to address these challenges and improve the lives of patients everywhere.

PI_NAMEs: AZAGURY, DAN  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Address;Area;Assessment tool;Biomedical Engineering;Biomedical Technology;Businesses;career;Clinical;clinical practice;Course Content;Data;design;Development;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Engineering;Evaluation;experience;Face;falls;Feedback;Funding;Glean;Goals;Hand;Health Technology;Healthcare;Hour;human centered design;Immersion;improved;innovation;insight;International;Interview;Learning;learning strategy;medical schools;Medicine;Mentors;Methodology;Methods;Patients;Process;programs;Research;Running;Series;skills;Structure;student training;Students;summer program;summer research;technological innovation;Technology;Time;tool;Training;Training Programs;undergraduate student;Validation

PROJECT_TITLE: Stanford Biodesign/Bioengineering Clinical Need Identification Bootcamp for Undergraduates


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions

ORG_CITY: BERKELEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE This educational program is designed to train the next generation of population researchers in the methods in formal demography necessary for research in macroeconomic demography, biodemography, emerging data sources, as well as fertility and mortality trends. The kind of demographic training in this workshop - unavailable elsewhere in the United States - provides the tools and approaches to allow early career researchers to expand their abilities. The population research supported by this training will facilitate informed decision making on public health policies and other issues relevant to the health of the U.S. population.

PI_NAMEs: GOLDSTEIN, JOSHUA R. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Age;analytical tool;Area;Behavior;biodemography;California;career;career development;Cellular Phone;climate change;climate impact;Communicable Diseases;Communities;community building;Complex;Country;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Data Sources;Decision Making;Demographer;Demography;design;Development;digital;Disease;Distance Learning;early-career faculty;Education;Educational Status;Educational workshop;Elements;Event;Exercise;experience;Exposure to;Faculty;Fertility;Fostering;Funding;Generations;Goals;graduate student;Health;Health Policy;Human;Inequality;innovation;insight;Institution;Instruction;instructor;Interdisciplinary Study;interest;Language;Longevity;mathematical methods;mathematical model;Mathematics;Measurement;Measures;meetings;Methodology;Methods;migration;Modeling;Modernization;mortality;next generation;Participant;Personal Satisfaction;Population;Population Dynamics;Population Growth;population health;Population Process;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;programs;Public Health;quantum;Research;Research Personnel;Resources;Scientist;Shock;Site;skills;social media;social science research;Social Sciences;Statistical Models;Structure;success;symposium;Techniques;Time;tool;Training;Training Programs;Training Support;trend;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Workshops in Formal Demography

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative: With antiretroviral therapy, children living with perinatally-acquired HIV are surviving into adulthood and will need to transition to adult care to achieve long-term successful outcomes. Adolescents living with HIV and transitioning to adult care have shown high rates of mortality, virologic failure, and loss to follow up. The proposed research will evaluate in-person and mHealth delivered adolescent-friendly transition interventions compared to standard of care among adolescents with low transition readiness in a randomized clinical trial and evaluate implementation factors associated with each intervention in urban and rural settings.

PI_NAMEs: ARCHARY, MOHERNDRAN ;ZANONI, BRIAN C. (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Absenteeism;acceptability and feasibility;Address;Adolescence;Adolescent;Adoption;Adult;Advocacy;Africa South of the Sahara;Age;antiretroviral therapy;Appointment;Caring;Cessation of life;Child;Childhood;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Cohort Studies;Communication;comparison intervention;cost;Country;COVID-19 pandemic;Death Rate;design;Development;Disclosure;Disparity;Effectiveness;effectiveness evaluation;effectiveness measure;effectiveness/implementation design;Enrollment;evidence base;Failure;Feedback;follow-up;Friends;Funding;Future;health care delivery;health literacy;Healthcare;HIV;HIV-infected adolescents;Hour;hybrid type 1 design;implementation determinants;implementation evaluation;implementation measures;implementation science;implementation strategy;Improve Access;improved;improved outcome;Income;Individual;innovation;Intervention;Lead;Maintenance;Measures;Mediating;mHealth;mhealth interventions;Observational Study;Outcome;pediatric human immunodeficiency virus;peer;peer support;Perinatal;Persons;Pharmacy facility;Principal Investigator;programs;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Research;Research Personnel;Resources;Rural;rural setting;scale up;Schools;service intervention;Services;Site;social;social media;social stigma;Social support;South Africa;standard care;standard of care;Translational Research;United States National Institutes of Health;uptake;urban setting;Validation;Viral;Viral Load result;virtual;virtual intervention;vulnerable adolescent;World Health Organization;Youth

PROJECT_TITLE: Interactive Transition Support for Adolescents Living with HIV Comparing Virtual and In-person delivery through a stepped-wedge cluster randomized clinical trial in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-M(53)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Data Science;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative We will develop a novel computational data-driven framework for identifying molecular features across multiple scales to study antibiotic resistance (AR) in ESKAPE pathogens. This work will develop broadly usable methods and data science technologies — open software, open FAIR data repositories, and web platforms — to understand and target AR in new and (re)emerging pathogens. Our project will get us closer to ending the arms race between microbes and drugs, serving the core mission of NIAID and global public health.

PI_NAMEs: RAVI, JANANI  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Amino Acid Motifs;Amino Acid Sequence;Antibiotic Resistance;Antibiotics;arms race;Award;Bacteria;Bacteriophages;base;Bioconductor;Bioinformatics;Case Study;Cell surface;Cessation of life;Clinical;Collaborations;Communities;community building;comparative;computational platform;computer framework;Computer software;Consumption;Data;data integration;data platform;data repository;data reuse;Data Science;Data Set;Databases;Development;Diagnostic;diverse data;Documentation;Drug Screening;Ecosystem;Educational workshop;emerging pathogen;Ensure;ESKAPE pathogens;Evolution;experimental study;explainable machine learning;FAIR principles;Family;Funding;Genes;Genetic Screening;Genome;Genome Scan;Genomic Islands;genomic variation;Genomics;healthcare burden;helicase;heterogenous data;improved;Individual;Infection;insight;interoperability;knowledge graph;knowledgebase;Libraries;Machine Learning;machine learning prediction;Metabolic;Methods;Microbe;microbial;Mission;Modernization;Molecular;Molecular Evolution;molecular scale;multiple data types;Mutation;National Institute of Allergy and Infectious Disease;Neighborhoods;novel;open data;pathogen;pathogen genome;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Plasmids;Point Mutation;Predisposition;Proteins;Public Health;Research;Research Personnel;Resistance;resistance allele;Resistance development;resistance gene;resistance mechanism;resistance mutation;Scanning;Shock;software development;Structure;Sulfur;System;Technology;Tertiary Protein Structure;Testing;Time;tool;Treatment outcome;usability;user-friendly;Virulence Factors;web platform;webinar;Work

PROJECT_TITLE: Leveraging evolutionary analyses and machine learning to discover multiscale molecular features associated with antibiotic resistance


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Public Health Relevance Statement The promise of human pluripotent stem cells as a research and therapeutic tool is critically hinged on efficient culture protocols that can promote directed differentiation of these cells towards different adult cell types with high yield and purity. This research will develop and implement new technologies to investigate how the mechanical signals in the pluripotent stem cell culture can be utilized to improve their differentiation efficiency towards functional motor neurons, loss of which is associated with spinal cord injury, amyotrophic lateral sclerosis, and spinal muscular atrophy. Our research can potentially enable drastic advances in large-scale production of functional motor neurons and thus contribute significantly to future motor neuron-based regenerative therapies and drug and toxicology screens.

PI_NAMEs: DENG, CHERI X;FU, JIANPING  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acceleration;Acoustics;Adoption;Adult;Age;ALS patients;Amyotrophic Lateral Sclerosis;Axon;Biological Assay;Biomechanics;Biomedical Engineering;Biophysics;blastocyst;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cell Therapy;cell type;Cells;Clinical;clinically relevant;Cues;Cytometry;Cytoskeleton;Data;Degenerative Disorder;Derivation procedure;design;Development;differentiation protocol;directed differentiation;Disease;disease model;Drug Screening;Embryo;Embryonic Development;embryonic stem cell;Engineering;Epiblast;Ethnic Origin;Future;Generations;Genetic Diseases;Goals;Grant;Human;Human Development;human induced pluripotent stem cells;human pluripotent stem cell;implantation;improved;In Vitro;in vivo;Infection;Inflammation;Injury;Integrins;interest;invention;Investigation;large scale production;Malignant - descriptor;mechanical force;mechanical signal;Mechanical Stimulation;Mediating;Microbubbles;Morphogenesis;Motor Neuron Disease;Motor Neurons;Muscle;nerve stem cell;Nervous System Disorder;neural;Neuroepithelial;Neuronal Differentiation;Neurons;new technology;novel;novel strategies;novel therapeutics;operation;Pathway interactions;Periodicity;Pharmaceutical Preparations;pharmacologic;Physical environment;pluripotency;Pluripotent Stem Cells;Process;Property;Protocols documentation;public health relevance;Regenerative Medicine;regenerative therapy;Reporting;Research;Role;self-renewal;sex;Signal Transduction;single cell analysis;Source;Spatial Distribution;Specific qualifier value;Spinal Cord;Spinal cord injury;Spinal Muscular Atrophy;stem cells;System;Technology;Testing;Therapeutic;tool;Toxicology;Transcription Coactivator;Trauma;ultrasound

PROJECT_TITLE: Acoustic Tweezing Cytometry for Efficient Neural Differentiation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Neural stem/progenitor cells (NSPCs) lie in close proximity to blood vessels in the normal brain and after cell transplant to treat neurological conditions. We studied the interaction of human NSPCs and human endothelial cells that make blood vessels and found that endothelial cell contact changed the character of human NSPCs while the NSPCs produced factors that caused vessel formation. Our studies could optimize co-transplants of human NSPCs and human endothelial cells in bioengineered scaffolds to recreate critical interactions and stimulate brain repair.

PI_NAMEs: FLANAGAN, LISA A (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Adult;Affect;B-Lymphocytes;Biomedical Engineering;Blood Vessels;Brain;brain cell;brain repair;Brain Stem;brain tissue;Cell Communication;Cell Physiology;Cell secretion;Cell Transplantation;cell type;Cells;Cerebrovascular system;Communication;Complex;Data;Endothelial Cells;endothelial stem cell;Environment;exosome;extracellular vesicles;Future;Generations;Glial Fibrillary Acidic Protein;Goals;Human;human stem cells;Image;In Vitro;in vivo;Injury;insight;Knowledge;Lead;mechanical properties;Mediating;migration;Molecular Profiling;nerve stem cell;neurogenesis;Neurologic;Neurons;novel;Pathway interactions;Patients;Phenotype;post-transplant;prevent;Property;Regulation;repaired;Rodent;scaffold;single-cell RNA sequencing;stem cell biomarkers;stem cell niche;stem cell self renewal;Testing;Therapeutic;Tissue Engineering;transcriptome;Transplantation;vasculogenesis

PROJECT_TITLE: Human neural stem cell and endothelial cell reciprocal interactions govern cell function


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Over 200,000 people in the US develop deep vein thromboses (DVT) annually and over 43% of these patients will develop post-thrombotic syndrome (PTS), leading to a lowered quality of life. DVT is treated with catheter directed thrombolysis in addition to anti-coagulation therapy, which does not prevent the development of PTS. Thus, this research proposal seeks to elucidate the mechanisms of DVT formation and resolution, in order to identify therapeutic targets leading to the optimal treatment of DVT and its sequelae and increase the quality of life for patients.

PI_NAMEs: MATHEWS, RICK  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Academic Medical Centers;Adhesions;Affect;Age;Animals;Antibodies;Anticoagulation;Binding;Binding Sites;Biomedical Engineering;Blood;Blood flow;Blood Platelets;Blood Vessels;Cardiovascular Diseases;career;career development;Catheters;Cause of Death;CCL2 gene;CD14 gene;Cell Communication;cell injury;Cell Proliferation;Chondroitin Sulfates;Coagulation Process;Communication;Complete Blood Count;constriction;Data;deep vein;Deep Vein Thrombosis;design;Development;Disease;Doctor of Philosophy;Endothelial Cells;Enzymes;Etiology;Exhibits;Factor XI;Factor XIa;ferumoxytol;Fibrin;Fibrinolytic Agents;Flow Cytometry;Functional disorder;Genetic Markers;Glycocalyx;Glycoproteins;Glycosaminoglycan Degradation Pathway;Glycosaminoglycans;glycosylation;Goals;Health;Hematology;Hemostatic function;Heparin Cofactor II;Heparitin Sulfate;Hyaluronan;Impairment;In Vitro;in vivo evaluation;Incidence;Inferior vena cava structure;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;injured;Interleukin-1 beta;Interleukin-13;Intervention Studies;Investigation;Laboratories;Leadership;Long term disability;Macrophage;Magnetic Resonance Imaging;Measures;Mediator;Membrane;Mentorship;Modeling;monocyte;monolayer;mouse model;Mus;neutrophil;Operative Surgical Procedures;optimal treatments;Oregon;Pathway interactions;Patients;PECAM1 gene;Perfusion;Permeability;Persons;Phenotype;Physicians;Platelet Activation;Platelet-Derived Growth Factor;Play;Postoperative Period;Postphlebitic Syndrome;Prednisone;Process;Productivity;Proliferating;Proteoglycan;Quality of life;Recurrence;Research Proposals;Resolution;Role;Saline;Science;Scientist;Senior Scientist;sham surgery;Signs and Symptoms;skills;Smooth Muscle Myocytes;Stains;Surface;Techniques;therapeutic target;Thrombin;thrombolysis;Thrombophilia;Thrombosis;thrombotic;Thrombus;TNF gene;Training;Transforming Growth Factor beta;ultrasound;Universities;Vasodilation;Veins;Venous;venous thromboembolism;Weight

PROJECT_TITLE: Role of glycosaminoglycans (GAGs) in deep vein thrombus formation and resolution


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Metformin is thought to module multiple molecular pathways involved in aging. The goal of this project is to study the effects of metformin on pillars (hallmarks) of aging in older adults and establish whether changes in pillars of aging are linked to changes in clinically-relevant outcomes.

PI_NAMEs: ESPINOZA, SARA ELYSE (contact);MUSI, NICOLAS

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adipose tissue;Adult;Aging;aging biomarker;aging process;aging related disease;Animals;Applications Grants;Biological;biological age;Biometry;Blood;Cell Aging;Clinical Trials;clinically relevant;Cognition;DNA Methylation;Dose;epidemiologic data;epigenetic clock;Epigenetic Process;Fluorescent Antibody Technique;frailty;functional improvement;Funding;Geroscience;glucose and insulin clamps;glucose metabolism;glucose tolerance;Goals;hallmarks of aging;healthspan;Human;human old age (65+);human subject;improved;indexing;Inflammation;innovation;Institution;insulin signaling;Intervention;Intervention Studies;Invertebrates;Life Extension;Link;Longevity;MAP Kinase Gene;mass spectrometric imaging;Measures;Mediation;mental state;Metabolic;Metabolism;metabolomics;Metformin;Methodology;Mitochondria;Modeling;Modification;Molecular;Muscle;muscle form;muscle strength;novel;older adult;Outcome;parent grant;Parents;Pathway interactions;pharmacologic;Phenotype;phenotypic data;Physical Function;Physical Performance;Placebos;prevent;Proteomics;randomized placebo controlled trial;randomized placebo-controlled clinical trial;Reactive Oxygen Species;Research;Resolution;Respiration;Rodent;senescence;skeletal tissue;Specimen;Spirometry;Testing;Time;Tissue imaging;Tissues;transcriptomics;Urine;Walking

PROJECT_TITLE: Does Metformin Modulate the Pillars of Aging in Older Adults?


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative The central research mission of our lab is to uncover the core principles underlying the assembly heterochromatin, a central gene-repressive element in the genome. Heterochromatin assembly heritably partitions the genome into active and inactive regions and in its normal state, this process drives cellular differentiation, while when misregulated, underlies a variety of diseases, including several cancers. We propose an integrative approach to define central cellular and biochemical mechanisms of dynamic heterochromatin assembly, ranging from single molecule biophysical to real-time single-cell measurements, which will reveal crucial intervention points for tuning this reaction in disease treatment, regenerative medicine, and synthetic biology.

PI_NAMEs: AL-SADY, BASSEM  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Behavior;Biochemical;Biophysics;Cell Differentiation process;Cells;Chemicals;Chromatin;Contracts;Development;Disease;DNA Sequence;Elements;Environment;Epigenetic Process;Fission Yeast;gene repression;Genes;Genetic;Genome;Heritability;Heterochromatin;histone methylation;Histones;Individual;Intervention;Laboratories;Lysine;Malignant Neoplasms;Measurement;Methods;Methylation;Methyltransferase;Mission;Modeling;Molecular;Molecular Machines;Multienzyme Complexes;Nuclear;Pattern;preservation;Process;Reaction;Recording of previous events;Regenerative Medicine;Research;sensor;Signal Transduction;single molecule;stem cells;synthetic biology;System;Time;Writing

PROJECT_TITLE: Tracking how molecular machines propagate epigenetic information in time and space

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE In this application, I propose a research program of developing novel statistical methods and open-access tools for genetic epidemiology studies to innovatively tackle open problems in human trait genetics, methods for which are outdated or scarce or have shown limited progress in recent years. In particular, we seek to address methodological challenges in identifying non-additive genetic effects, effects of rare variants, and in prioritizing causal variants through integrative omics. This research program will support diversity in three distinct ways, will broadly apply to human health, and will impact strategies for analyzing multi-ethnic family- & hybrid designs and approaches used to aggregate summary-level data across the allele frequency spectrum.

PI_NAMEs: RAY, DEBASHREE  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Admixture;Adult;Attention;biobank;Biology;causal variant;Child Health;Complex;Complex Genetic Trait;Data;Data Science;Databases;design;Disease;Ethics;ethnic diversity;experience;Explosion;Family;gene environment interaction;Gene Frequency;gene interaction;Genes;Genetic;genetic epidemiology;Genetic study;genome wide association study;Genomics;Genotype;graduate student;Health;Human;Hybrids;improved;Individual;innovation;Investigation;Literature;Low Prevalence;Mathematics;Mentors;Methodology;Methods;Molecular;multi-ethnic;multidisciplinary;novel;Outcome;Parents;Participant;Play;Policy Making;population based;population stratification;Population Study;Positioning Attribute;programs;Public Health Applications Research;Public Health Schools;Race;Rare Diseases;rare variant;Reproducibility;Research;Research Personnel;Resource-limited setting;Role;Sample Size;skills;Statistical Methods;statistics;Student recruitment;tool;Training;trait

PROJECT_TITLE: Methods for leveraging family-based designs and summary data to elucidate complex trait genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: PROJECT NARRATIVE This project uses speech and language analysis (ASLA) as an objective, low-cost approach for dementia detection and monitoring in Latinos, a large and underserved minority. Leveraging a large cohort from Latin America and the United States (n = 2740), we will employ machine and deep learning to (a) test the diagnostic utility of ASLA markers; (b) correlate them with cognitive and neuroimaging features; and (c) identify those that are robust across, languages, dialects, and socio-biological variables. In the long term, this research will provide equitable tools for early diagnosis and monitoring of dementia in Latinos, reducing testing cost and time, avoiding biases of examiner-based tests, differentiating syndromes beyond common-cause confounds, and enabling timely adoption of neuroprotective life changes and pathology-targeted therapies.

PI_NAMEs: GARCIA, ADOLFO MARTIN;GORNO TEMPINI, MARIA LUISA  (contact);IBANEZ, AGUSTIN M.

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acoustics;Address;Adoption;Affect;Alzheimer's Disease;Atrophic;Award;behavioral variant frontotemporal dementia;bilingualism;Biodiversity;Biological;Biological Factors;Brain;brain health;cerebral atrophy;Certification;Classification;Climacteric;Clinical;Cognitive;Cognitive deficits;cohort;Collection;cost;Country;Data;deep learning;deep learning algorithm;Dementia;Detection;Diagnosis;Diagnostic;Diagnostic tests;diagnostic value;Differentiation Antigens;digital;Disease;Early Diagnosis;Education;Ensure;Environment;Equity;ethnoracial;forging;Frontotemporal Dementia;Functional Magnetic Resonance Imaging;Funding;Glean;Grain;Grant;high dimensionality;Image;Impaired cognition;improved;Inequity;innovation;Language;Latin America;Latin American;Latino;Latino Population;Life;Linear Regressions;Linguistics;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Manuals;Measures;Methods;Minority;minority communities;Monitor;multimodal data;neural;neural correlate;Neurocognitive;neuroimaging;neuroprotection;novel;Outcome;outreach;Paper;Participant;Pathology;Pattern;Persons;Population;predictive marker;Prevalence;Primary Progressive Aphasia;Procedures;Protocols documentation;Publications;Race;recruit;Reproducibility of Results;Research;Research Personnel;Semantics;sex;Site;skills;social culture;social health determinants;Solid;sound;Source;Spanish;Speech;standard measure;Surveys;Syndrome;targeted treatment;Testing;Time;tool;Training;Underrepresented Populations;underserved minority;United States;Variant;Visualization

PROJECT_TITLE: An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populations

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE Progression of HIV disease and premature deaths among persons living with HIV (PLWH) have been attributed foremost to insufficient engagement in medical care and adherence to HIV treatment regimens. In response, this study will test the efficacy and implementation factors of WiseApp, an evidence-based self-management medication adherence tool with Spanish-speaking PLWH in New York City and the Dominican Republic. This application has considerable public health relevance because it is delivered to an ethnic minority group who are disproportionally affected by HIV.

PI_NAMEs: SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Dissemination of the WiseApp for Improving Health Outcomes Across Settings

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Digestive Diseases;Foodborne Illness;Infectious Diseases;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Infectious diarrheal diseases, such as rotavirus, are leading causes of sickness and death in children worldwide despite several vaccines being available. During infection, a rotavirus protein called nonstructural protein 4 (NSP4) takes over the cell’s communication systems and reprograms the cell to promote rotavirus replication and cause diarrhea and vomiting. This proposal makes use of new genetic tools to map the parts of NSP4 responsible for commandeering cellular communication machinery, which will help us improve anti-diarrheal drugs and develop better vaccines.

PI_NAMEs: CRAWFORD, SUE ELLEN;ESTES, MARY KOLB;HYSER, JOSEPH M. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 5 year old;Acute;Address;Agonist;Antidiarrheals;Astrovirus;Attenuated;Biological Models;Calcium Signaling;Cell Communication;Cell membrane;Cells;Cessation of life;Child;Childhood;Chlorides;Communication;Cytoplasmic Tail;Cytosol;Defect;Diarrhea;diarrheal disease;Disease;Disease Pathway;Drug Targeting;Dysentery;Endoplasmic Reticulum;Enteral;Enterocytes;Enterotoxins;Event;Exhibits;experience;experimental study;extracellular;fascinate;Functional disorder;Genetic;global health;Goals;Homeostasis;Hour;Human;human pathogen;Image;improved;in vivo;Infection;insight;Intestines;Ion Channel;knock-down;Knowledge;Maps;Mediating;mimicry;Modeling;Molecular;mortality;Mus;mutant;Mutation;neonatal mice;new therapeutic target;Nonstructural Protein;Norovirus;novel;Nuclear;Paracrine Communication;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Physiology;Play;Point Mutation;Process;programs;Protein Biosynthesis;protein expression;Proteins;pup;receptor;Recombinant Proteins;Research;reverse genetics;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Signal Pathway;Signal Transduction;System;Tertiary Protein Structure;theories;tool;vaccine access;vaccine efficacy;Vaccines;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Vomiting

PROJECT_TITLE: Dissecting Rotavirus Viroporin and Enterotoxin Calcium Signaling Pathways

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: ARCATA

ORG_DEPT: BIOLOGY

ORG_NAME: HUMBOLDT STATE UNIVERSITY

PHR: Project Narrative  Deer ticks are spreading across the Pacific West Coast of the United States and making people sick because they carry deadly bacteria. The proposed research is to study a novel potentially dangerous bacterium in deer ticks, called Rickettsia species phylotype G022, by studying the survival of the bacterium in deer ticks, detecting the infection rate of the bacterium in pet dogs, and giving it a unique scientific name. Our findings will advance the vital long-term research goal of our lab, investigating the suspicion that the G022 bacterium poses a risk of infection to humans and domestic animals across the Pacific West Coast.

PI_NAMEs: ZHONG, JIANMIN  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acceleration;Adult;Anaplasmosis;Animals;Arthropods;Bacteria;Biological Assay;Biology;Black-legged Tick;Bobcat;California;Canis familiaris;Cell Line;Classification;cost;County;Dangerousness;Data;detection method;Diagnosis;DNA;Domestic Animals;Ecology;Educational Curriculum;embryo cell;Emerging infection;Exanthema;experience;exposed human population;Exposure to;feeding;Felis catus;Fever;foxes;Funding;Genomics;Goals;graduate student;Hispanic-serving Institution;Human;Human Bites;human disease;Infection;infection rate;infection risk;insight;Ixodes;Ixodidae;Learning;Life;Low Prevalence;lower income families;Lyme Disease;Medical;Methods;Molecular;Names;New Zealand;next generation sequencing;North America;Northern America;novel;Nymph;Oryctolagus cuniculus;Outcome;pathogen;Pathogenesis;Pathogenicity;Persons;Phylogenetic Analysis;Prevalence;Proteomics;Public Health;Publishing;Qualifying;Research;Rickettsia;Rickettsia Infections;Route;Rural Community;Science;serosurvey;spotted fever;Students;success;Surveys;Symptoms;tick bite;Tick-Borne Diseases;tick-borne pathogen;Ticks;Time;Training;transmission process;Trees;undergraduate student;underrepresented minority student;United States;Universities;vector;Work

PROJECT_TITLE: The Ecology and Classification of Rickettsia Species Phylotype G022, an Uncharacterized Bacterium from Ixodes pacificus Ticks


NIH_SPENDING_CATS: Aging;Clinical Research;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Menopause;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PHR: There is overwhelming evidence that female reproductive aging influences lifespan and diverse health outcomes. To gain insights into the molecular basis of reproductive aging and its influences in later life health outcomes, we aim to characterize gene regulatory landscapes that are altered in the ovary during aging and that are causally linked to genetic factors influencing age at menopause.

PI_NAMEs: ROSENFELD, MICHAEL G;SUH, YOUSIN ;WILLIAMS, ZEV  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Affect;Age;age effect;Aging;ATAC-seq;Attention;Birth;Body System;cancer type;Cardiovascular Diseases;causal variant;Cell model;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Development;Disease;Engineering;Enhancers;Exhibits;Feedback;Female;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;granulosa cell;Growth;Health;healthspan;Homeostasis;Human;Human body;human embryonic stem cell;improved;in silico;Individual;Inflammatory;insight;interdisciplinary approach;late life;Licensing;Life Expectancy;life span;Link;Longevity;Menopause;Messenger RNA;Metabolic syndrome;Methodology;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;Nuclear RNA;Oocytes;Organ;Outcome;Ovarian;Ovarian aging;Ovariectomy;Ovary;Pathologic;Postmenopause;Preparation;programs;Proxy;Reproductive Periods;Reproductive Process;reproductive senescence;Risk;Role;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Supporting Cell;Surveys;Technology;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transplantation;Trees;trustworthiness;Variant;Woman;women's outcomes

PROJECT_TITLE: Regulatory Landscape of the Aging Human Ovary


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Prolonged social isolation results in a host of negative outcomes on mental health, including increased violence, and so represents a major public health concern. Despite this, the neural correlates of social isolation the resulting aggression remain poorly understood. Using sophisticated behavioral and computational analyses, perturbations of genetically defined neuronal populations, and in vivo imaging, the project proposed here aims to uncover the unique circuit mechanisms which exert top-down control over isolation-induced aggression, thereby informing the development of novel treatments for mental health disturbances resulting from social isolation.

PI_NAMEs: GATLIN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adolescent;Aggressive behavior;Anxiety;Behavior;Behavioral;Biological Assay;Brain;Brain region;Calcium;calcium indicator;career;cell type;Chronic;Color;Computer Analysis;Confocal Microscopy;COVID-19 pandemic;Data;Data Analyses;Development;Endoscopy;Equilibrium;Exhibits;Feeling;Fellowship;Female;gamma-Aminobutyric Acid;Genes;Genetic;Genetic Identity;Goals;Health;hippocampal pyramidal neuron;House mice;Image;imaging approach;implantation;In Situ Hybridization;in vivo;in vivo imaging;insight;Institution;Interneurons;knock-down;Knowledge;Lead;lens;Link;loss of function;male;Measures;Medial;Mediating;Mental Depression;Mental Health;microendoscopy;Modeling;Mus;neural correlate;Neurobiology;Neurokinin B;Neuromedin K Receptor;Neurons;Neuropeptides;Neurosciences;novel;Operative Surgical Procedures;Outcome;Pattern;Population;Positioning Attribute;Postdoctoral Fellow;Prefrontal Cortex;Process;professor;Public Health;Research;Rodent;Role;Signal Transduction;skills;social;Social Behavior;Social Environment;Social Interaction;Social isolation;social separation;Stress;stressor;System;Tachykinin;Technical Expertise;Testing;Training;Violence;Viral;Work

PROJECT_TITLE: Top‐Down Control of Isolation‐Induced Aggression Through mPFC Tac2+ Interneurons


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Natural killer (NK) cells are innate immune effector cells that may be engineered for cancer immunotherapy by expression of chimeric antigen receptors (CARs), engineered proteins that direct NK cells to kill cancer cells. Our proposed studies will generate a fundamental understanding of intracellular signaling mediated by NK-CARs to enable efficient design of optimal CARs for multiple myeloma. This research has the potential to unlock the transformative power of NK-CAR cells for cancer immunotherapy.

PI_NAMEs: FINLEY, STACEY DELERIA (contact);GRAHAM, NICHOLAS ALEXANDER

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Activated Natural Killer Cell;Antigens;B-Lymphocytes;cancer cell;cancer immunotherapy;cell killing;Cell Maturation;Cell Physiology;cell type;Cell-Mediated Cytolysis;Cells;Cellular biology;chimeric antigen receptor;chimeric antigen receptor natural killer cells;Complex;Computer Models;cytokine;cytotoxic;cytotoxicity;Data;Data Set;data-driven model;design;Development;Disease;Effector Cell;engineered T cells;Engineering;Equilibrium;experience;Flow Cytometry;Host Defense;Human;Immune;immune function;Immunotherapy;in vitro testing;in vivo;insight;interest;Kinetics;Knowledge;Libraries;Ligands;Link;Machine Learning;Mass Spectrum Analysis;mathematical model;Mathematics;Measures;Mediating;Membrane;Methods;Modeling;Molecular;mouse model;Multiple Myeloma;Natural Killer Cell Immunotherapy;Natural Killer Cells;NK Cell Activation;novel;Outcome;Pathway interactions;phosphoproteomics;Phosphorylation;Play;predictive modeling;Protein Engineering;receptor;Receptor Cell;Receptor Signaling;receptor-mediated signaling;Research;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Source;Structure;success;Systems Biology;T-Lymphocyte;Testing;Time;tool;tumor;Tumor Antigens;Western Blotting;Work

PROJECT_TITLE: Modeling based design of chimeric antigen receptors for Natural Killer cell-based immunotherapy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE:  Pyramidal neurons in the primary visual cortex (V1) undergo dynamic plasticity changes throughout visual associative learning. This proposal will define which learning events drive differential plastic changes in V1 and how learning or V1 activity shape cortico-cortical functional connectivity. We expect our findings to provide important insight into the behavioral underpinnings of V1 and cortico-cortical plasticity throughout learning.

PI_NAMEs: BATCHELOR, HANNAH MARIE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Plasticity of cortical networks during learning


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Urologic Diseases

ORG_CITY: MADISON

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE During the aging process, nearly all men experience lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia/hypertrophy (BPH). The proposed research addresses an unmet need in the urological field by performing mechanistic and preclinical studies that underpin aging molecular mechanisms that mediate processes integral to the development of BPH/LUTS.

PI_NAMEs: RICKE, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 2 year old;3-Dimensional;Acceleration;Address;Adrenergic Agents;Adult;Age;age related;aged;Aging;aging mechanism;aging process;aging related disease;Anatomy;Androgens;animal data;Animal Model;Animals;Area;Automobile Driving;Benign Prostatic Hypertrophy;Biogenesis;Biological Assay;Biology;burden of illness;Cell Aging;Cells;Chemicals;Clinical Trials;clinically relevant;Collagen;comorbidity;Complex;Computer software;Data;Development;Disease;effectiveness testing;Electron Transport;Event;experience;experimental study;Extracellular Matrix;fall risk;FDA approved;Fibrinogen;Fibroblasts;Fibrosis;Fracture;Functional disorder;Functional impairment;Future;Genetic;Genetic Induction;Genus Hippocampus;Gland;Goals;hallmarks of aging;Health;healthspan;Histologic;Histopathology;Homeostasis;Human;human model;Hyperplasia;Hypertrophy;Image;improved;In Vitro;in vivo;Increased frequency of micturition;Inflammation;inhibitor;Intervention;Lower urinary tract;lower urinary tract symptoms;Magnetic Resonance Imaging;male;Malignant Neoplasms;man;Measures;Mediating;men;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Electron Transport Complex I;Modeling;Molecular;mortality;mouse model;Mus;Mutation;Myofibroblast;Nodule;Non-Malignant;normal aging;novel;Octogenarian;old mice;Outcome Measure;Oxygen Consumption;Pathologic;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;preclinical study;Predisposition;Process;Production;Proliferating;Prostate;Prostatic;Prostatic hypertrophy;prototype;Public Health;Quality of life;Race;racial difference;Reactive Oxygen Species;reconstruction;Reproduction;reproductive;Research;Respiration;restoration;Risk Factors;Role;senolytics;sex;side effect;Specimen;spectrograph;Stromal Cells;Symptoms;Testing;therapeutic development;Tissues;translational impact;translational potential;Treatment Cost;ultrasound;Urethra;urinary;urologic;Work

PROJECT_TITLE: Elucidating hallmarks of aging in the development of lower urinary tract dysfunction (LUTD)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Huntington's Disease;Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Recent advances toward potential disease-modifying therapies in Huntington disease (HD) present an urgent need to identify early, quantifiable markers of disease progression in youth and young adults at risk for HD. The goals of this study are to characterize impulsive behaviors as an early marker of HD and to examine the influence of genetic status, environmental stressors, and inhibitory control as potential predictors of these behaviors. These results will lead to better understanding and improved detection of the earliest symptoms of HD, which will help to guide the development of new therapies for those at risk of developing this fatal disease.

PI_NAMEs: MCDONELL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adult;adverse childhood events;Affect;Age;Aggressive behavior;Anxiety;Attention;Automobile Driving;autosome;Award;Behavior;behavior prediction;Behavioral;Biological Markers;Blinded;CAG repeat;career development;Child;Child Psychology;Childhood;Chronic stress;Clinical;Clinical Trials;Cognitive;cohort;Coping Skills;Data;Data Analyses;Data Set;Dedications;Detection;Development;Developmental Course;Diagnosis;Disease;Disease Marker;Disease Progression;Early identification;Electroencephalography;Electrophysiology (science);environmental stressor;Equipment and supply inventories;Event-Related Potentials;Executive Dysfunction;executive function;Exhibits;experience;externalizing behavior;Face;Family;follow-up;Funding;Future;Gene Silencing;Genes;Genetic;Genetic Status;genetic testing;Goals;Human Development;Huntington Disease;Huntington gene;Impairment;improved;Impulsive Behavior;Individual;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Lead;Length;Longitudinal cohort;Longitudinal Studies;Measures;Mental Depression;Mental disorders;Mentors;Mentorship;Modeling;Monitor;Motor;motor symptom;multidisciplinary;mutant;Nerve Degeneration;neural correlate;Neurobiology;Neurodegenerative Disorders;neurodevelopment;neurodevelopmental effect;Neurologist;neurophysiology;neuropsychiatric symptom;neuropsychiatry;novel;novel therapeutics;Outcome Measure;Participant;Patient Self-Report;Patients;pediatric trauma;Persons;Phase;Phenotype;Physicians;Population;Positioning Attribute;Prevalence;prospective;Protocols documentation;Psychological Models;Questionnaires;Reporting;Research;response;Risk;Risk Behaviors;Risk Taking;Scientist;skills;social;Stress;Substance abuse problem;Symptoms;Therapeutic Trials;Time;Training;training opportunity;United States;Work;young adult;Youth

PROJECT_TITLE: Inhibitory Control and Externalizing Behaviors in Youth at Risk for Huntington Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Poxviruses include some dangerous emerging pathogens as well as some promising vaccine vectors. Studying poxvirus host range mechanisms will provide knowledge for development of antiviral therapies and poxvirus-vectored vaccines. A new understanding on how host regulates translation in response to viral infection and how viruses evade this host response will provide fundamental insight into viral pathogenesis and benefit the development of new antiviral strategies.

PI_NAMEs: DENG, JUNPENG ;XIANG, YAN  (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Address;antagonist;antiviral drug development;arms race;Binding;cellular targeting;Codon Nucleotides;Complex;cytosolic receptor;Dangerousness;Data;Development;DNA;DNA Binding;DNA Binding Domain;ds-DNA;emerging pathogen;experimental study;Genes;Genetic Variation;genome-wide;Host Defense;Human Genome;Immune response;Infection;inhibitor;insight;Interferons;Knock-out;Knowledge;Mammalian Cell;Mediating;Modeling;Molecular;novel;Orthopoxvirus;overexpression;Pathway interactions;Pattern recognition receptor;Peptide Initiation Factors;Phenylalanine;Play;Poxviridae;poxvirus vectors;Predisposition;pressure;Process;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Publications;Regulation;Resistance;response;Ribosomal RNA;ribosome profiling;Ribosomes;Rodent;Role;Signal Transduction;Species Specificity;Specificity;Structure;transcriptome sequencing;Transfection;Transfer RNA;Translation Initiation;Translations;tRNA Methyltransferases;Vaccinia virus;vector vaccine;Viral;Viral Pathogenesis;Virus;Virus Diseases

PROJECT_TITLE: Novel Translational Control Mechanisms in Host Range Restriction of Poxvirus

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Infectious Diseases;Microbiome;Neurosciences;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The dopamine transporter and related family members are targets for medications, and secondary targets for psychostimulants such as amphetamine. In this proposal, we will determine how imbalances in the gut microbiome support the pathogenesis of amphetamine abuse and the role played by the dopamine transporter.

PI_NAMEs: CARTER, ANGELA MICHELLE;GALLI, AURELIO  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: abuse liability;Acetates;Acetylation;Adult;Affect;Amino Acids;Amphetamine Abuse;amphetamine use;Amphetamines;Animal Model;Attention Deficit Disorder;Attention deficit hyperactivity disorder;Behavior;behavioral phenotyping;behavioral response;blood-brain barrier crossing;Brain;Butyrates;Cessation of life;Chemosensitization;chromatin immunoprecipitation;Communication;court;Courtship;Cytoplasm;Data;Disease;Dopamine;dopamine transporter;Drosophila genus;Drosophila melanogaster;drug of abuse;dysbiosis;experience;experimental study;Exposure to;extracellular;Family member;Fermentation;fly;Fusobacterium nucleatum;genetic manipulation;Geography;Germ-Free;Gingivitis;Gnotobiotic;Grooming;Growth;gut colonization;gut microbiome;gut microbiota;gut-brain axis;HDAC1 gene;Health;histone acetyltransferase;Histone Deacetylase Inhibitor;Human;in vivo;inhibitor;Laboratories;Lead;Locomotion;Mediating;Messenger RNA;microbial products;microbiome;microbiome composition;Mississippi;Modeling;Molecular;Motor Activity;Neuroglia;Neurons;neuropsychiatric disorder;Oral Administration;Outcome;Pathogenesis;Periodontitis;Persons;Pharmaceutical Preparations;pharmacologic;Play;preference;Process;promoter;Property;Proteins;psychostimulant;Publishing;Reporting;RNA Interference;Rodent;Role;Stimulant;stimulant abuse;Substance Use Disorder;Techniques;Testing;Time;Translating;United States Substance Abuse and Mental Health Services Administration;Volatile Fatty Acids;Western Blotting

PROJECT_TITLE: The Role of Microbiome Composition in Amphetamine Abuse

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This RURAL Sleep Study will determine the prevalence of sleep disorders and sleep behaviors in the rural southern United States, their relation to social, environmental, and behavioral stressors, and their association with cardiovascular and metabolic risk. This will inform health care providers, public health officials, and the general public of the prevalence, risk factors, and consequences of impaired sleep health in the rural South, providing a critical basis for prevention, recognition, and management of sleep disorders and improvement of sleep and cardiometabolic health.

PI_NAMEs: GOTTLIEB, DANIEL J (contact);LEWIS, TENÉ T

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Age;aged;base;Behavioral;Blood Pressure;built environment;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;cohort;Communities;Complement;Complex;Data;Devices;Diet;Dimensions;Discrimination;Disease;disease stressor;disorder risk;Disparity population;Distress;Drops;Drowsiness;early life exposure;Enrollment;Environmental Exposure;Environmental Pollutants;Environmental Pollution;Environmental Risk Factor;environmental stressor;epidemiology study;Equilibrium;Etiology;Evaluation;experience;Exposure to;Financial Hardship;fitbit;General Population;hazard;Health;health care availability;health disparity;Health Personnel;Health Technology;Heterogeneity;High Prevalence;high risk;Home;human old age (65+);Impairment;improvement on sleep;Individual;Industrialization;Insulin Resistance;Intervention;Link;Longitudinal Studies;Measures;Metabolic;Metabolic Diseases;mHealth;Mississippi;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nature;neighborhood disadvantage;Obesity;Out-Migrations;Outcome;Oxygen;Oxygen saturation measurement;physical inactivity;poor sleep;Population;Population Distributions;Predisposition;Prevalence;Prevention;psychosocial;Psychosocial Factor;psychosocial stressors;Public Health;Questionnaires;Race;Recurrence;Research;resilience;resilience factor;Risk;Risk Factors;Rural;Rural Appalachia;rural area;Rural Community;rural dwellers;Rural Population;Sampling;sex;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;Smoking;social;social factors;Social Impacts;Social isolation;Standardization;Stress;stressor;substance use;systemic inflammatory response;Time;United States;urban area

PROJECT_TITLE: Sleep Health in the Rural South and Its Relationships with Cardiometabolic Health Disparities

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Fall prevention alarms do not prevent falls, interrupt workflow and serve as an auditory restraint to prevent patient mobility. The goal of this study is to compare high- and low-intensity coaching to reduce indiscriminate fall prevention alarm use in 30 medical and medical-surgical nursing units from 30 diverse hospitals participating in the National Database of Nursing Quality Indicators (NDNQI).

PI_NAMEs: MCNETT, MOLLY ;SHORR, RONALD I (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;Adverse event;Agitation;Auditory;Beds;behavioral economics;cancer care;Caring;Cessation of life;Cluster randomized trial;compare effectiveness;concept mapping;cost;Custom;Databases;Death Rate;Deimplementation;design;Devices;Diagnosis;Discipline of Nursing;Dissemination and Implementation;Dose;Economic Burden;Education;Effectiveness;Elderly;Evaluation;Event;evidence base;fall injury;Fall prevention;fall risk;falls;Feedback;Focus Groups;Frontline worker;Future;Goals;Health;Health Services;Healthcare;Hospital Costs;Hospital Nursing;Hospitals;Hybrids;implementation efforts;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;implementation study;improved;Incentives;Incontinence;Injury;Inpatients;Institution;Instruction;Interruption;Length of Stay;Litigation;Medical;Medical Care Costs;Medical-Surgical Nursing;medically necessary care;Methods;Mission;Mobility decline;Monitor;Nursing Homes;Operative Surgical Procedures;patient mobility;patient safety;Patients;Physical Restraint;prevent;Prevention strategy;Qualifying;Quality Indicator;Quality of Care;Quality of life;Reporting;Research Priority;research to practice;Resources;restraint;Safety;Science;Service setting;Site;Sleep disturbances;Stroke;System;Time;Translational Research;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: De-Implementing Fall Prevention Alarms in Hospitals

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stomach Cancer

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROGRAM NARRATIVE Gastric cancer is common globally. We seek to develop and characterize model systems (iPSCs, organoids) to reveal how gastric intestinal metaplasia and dysplasia, precursors to gastric cancer, form. In so doing, we will unravel new insights into potential applications for prevention, early detection, screening and surveillance.

PI_NAMEs: CRUZ-CORREA, MARCIA ROXANA;RUSTGI, ANIL K (contact);WELLS, JAMES M

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-Dimensional;Address;Alcohols;American Cancer Society;Asian;Autologous;Barrett Esophagus;Bile Acids;Bile Reflux;Biological Models;Biopsy;Black Populations;cancer diagnosis;cancer survival;carcinogenesis;carcinogenicity;Carcinoma;CDX2 gene;Cells;ChIP-seq;Chromatin;cigarette smoking;Coculture Techniques;Cues;Development;Diagnosis;Dietary Factors;Dysplasia;Early Diagnosis;East Asian;Epigenetic Process;Epithelial Cells;Epithelium;Esophagogastric Junction;Esophagus;ethnic difference;Ethnic Origin;Ethnic Population;Fibroblasts;Fostering;Fundus;Gastric Adenocarcinoma;gastric carcinogenesis;gastric intestinal metaplasia;Gastric mucosa;Gene Expression;Gene Mutation;Genetic;Genetic Transcription;Goals;health care disparity;Helicobacter Infections;High Prevalence;Hispanic Populations;Human;human data;human model;Immune;Incidence;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;innovation;insight;Institution;Intestinal Intraepithelial Neoplasia;Intestinal Metaplasia;Intestinal Mucosa;Intestines;loss of function;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metaplasia;microorganism;Molecular;mortality;mouse model;Mus;Mutation;Neoplasms;New York City;Not Hispanic or Latino;novel;Organ;Organoids;Outcome;Pacific Islander;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Peripheral Blood Mononuclear Cell;Play;Population Heterogeneity;prevent;Prevention;Process;programs;Property;Puerto Rico;Pyloric antrum;racial difference;racial population;Reporting;Repression;Resolution;risk stratification;Role;salt intake;Sampling;screening;single-cell RNA sequencing;SOX21 gene;spasmolytic polypeptide;stem cell model;Stomach;stomach cardia;Testing;Tissue Model;TP53 gene;transcription factor;Transcriptional Regulation;treatment strategy;Tumor Suppressor Genes;Universities;Upper digestive tract structure

PROJECT_TITLE: Mechanisms underlying gastric intestinal metaplasia and carcinogenesis


ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Overall Project Narrative The strategic goal of the Precision Aging Network is to develop the essential scientific knowledge and appropriate technologies to predict individual brain health risks and to discover personalized solutions to maximize cognitive healthspan. Because of the enormous heterogeneity in brain and cognitive functions among older individuals, the urgent challenge for science, medicine and healthcare providers is to discover interventions that are individually effective in delaying or preventing the onset of symptoms that arise from age- related cognitive impairment or brain disorders such as Alzheimer’s disease (AD) and AD-related dementias. To achieve this we will determine how specific categories of risk relate to brain aging and cognitive outcomes.

PI_NAMEs: BARNES, CAROL A. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Address;Age;Age-associated memory impairment;Aging;aging brain;aging process;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Arizona;Assessment tool;Baltimore;Behavioral Sciences;Big Data;Biological;biological age;Biological Markers;biopsychosocial factor;Blood;Brain;Brain Diseases;brain health;Categories;Chronic;Chronology;Clinical assessments;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;cognitive performance;cognitive testing;cohort;Communities;Complex;Critical Pathways;Data;data integration;data sharing;Dementia;design;Development;disability;Disease;Educational process of instructing;Environmental Risk Factor;Ethnic Origin;experience;extend lifespan;Foundations;Functional disorder;Future;Genetic;Geography;Goals;Health;Health Personnel;healthspan;Heterogeneity;high risk;Human;human old age (65+);Impaired cognition;improved;Incidence;Individual;Individual Differences;information gathering;Intervention;Knowledge;life span;Life Style;Longitudinal cohort;Medical;Medicine;Methodology;Methods;Modeling;multidisciplinary;National Institute on Aging;Neurologic;neuromechanism;Older Population;Online Systems;Outcome;outreach;Performance;Personal Satisfaction;Persons;physical conditioning;Population;precision medicine;predictive modeling;Predisposition;prevent;Prevention;Prevention strategy;Privatization;Process;process improvement;programs;Quality of life;Race;Research;Research Personnel;Resistance;Risk;Sampling;Science;sex;Signal Pathway;Social Sciences;socioeconomics;Sorting;Strategic Planning;Strategic vision;success;Symptoms;System;Technology;therapy development;tool;Translating;United States;Universities;web-based assessment

PROJECT_TITLE: Precision Aging Network: Closing the Gap Between Cognitive Healthspan andHuman Lifespan


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Advisory Committees;Aging;algorithmic methodologies;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Area;Bioinformatics;Brain;Businesses;clinical research site;Cognitive;Cognitive aging;Collection;commercialization;Communication;Communities;Complex;Conflict of Interest;Country;Data;design;Development;Effectiveness;Ensure;Epidemiology;Evaluation;experience;follow-up;Fostering;Funding;Goals;Grant;Health;Health Professional;healthspan;Human Resources;Human Subject Research;improved;industry partner;Institution;Intellectual Property;Intervention;Lead;Leadership;life span;Longitudinal cohort;Measures;meetings;member;molecular marker;Monitor;operation;Output;outreach;Performance;Personal Satisfaction;prevent;Process;Productivity;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Services;success;tool;Travel;Universities;Update

PROJECT_TITLE: Administrative Core (AC) Core A