NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease

ORG_CITY: PROVIDENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative  While sulfane sulfurs have been found to combat myocardial ischemia-reperfusion (MI/R) injury and heart failure, several essential questions about these small signaling molecules must be addressed to advance our understanding of their biological mechanisms and clinical potentials. In this project, we plan to develop a chemical toolbox of next generation fluorescent sensors for sulfane sulfurs and use them to probe how sulfane sulfurs protect cardiac cells under the development of disease. We believe these studies will establish a strong basis for the development of early diagnostic tools and therapeutics for cardiovascular disease by providing crucial, yet accessible tools needed to decipher the complex redox environments in the cardiovascular system and by deepening our knowledge of the roles of sulfane sulfurs at the cellular and subcellular levels.

PI_NAMEs: SHIEH, MEG  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Address;Advanced Development;Animal Model;Autophagocytosis;Award;Biological;Biological Assay;Biological Availability;Biological Markers;Biological Models;Biological Phenomena;biological systems;Biology;Blood;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular disorder therapy;Cardiovascular Pathology;Cardiovascular system;career;Cell model;Cells;Cellular biology;certificate program;Chemicals;Clinical;combat;commercialization;Complex;Confocal Microscopy;cytotoxicity;Data;Data Science;design;Detection;detection method;Development;Diagnostic;diagnostic tool;Disease;Educational process of instructing;Environment;ethnic disparity;Evaluation;Exhibits;Exposure to;Fellowship;Flow Cytometry;Fluorescence;Fluorescence Microscopy;Fluorescent Dyes;fluorophore;Future;gender disparity;Goals;Health;Heart Diseases;Heart failure;Homeostasis;human disease;Hydrogen Sulfide;improved;In Vitro;Individual;Institution;Knowledge;Lasers;Leadership;Liquid substance;Machine Learning;Maps;Mediating;Methods;Modification;Molecular Biology;Myocardial Ischemia;Myocardial Reperfusion Injury;near infrared dye;next generation;novel;Organelles;Organic Chemistry;Organic Synthesis;outreach;Oxidants;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathway interactions;Plasma;Positioning Attribute;prevent;Procedures;professor;Protocols documentation;quantum;ratiometric;Recording of previous events;Reperfusion Therapy;response;Role;sensor;Signaling Molecule;Sincalide;skills;Specificity;Sulfur;symposium;System;Testing;Therapeutic;therapeutic target;thioester;Tissues;tool;Training;Tube;Universities;Work

PROJECT_TITLE: Probing the cardioprotective effects of sulfane sulfurs with next generation fluorescent sensors


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE – OVERALL COMPONENT The Stanford Brain Metastasis Consortium has unified brain and cancer experts in the singular goal of improving our understanding and treatment of brain metastases, a currently increasing yet underserved subset of cancer patients. To accomplish the above goal, we have developed highly innovative and complementary Projects to understand and disrupt the cancer-neuro-immune axis supporting brain metastases, and created Research Cores to make human specimens and cutting-edge technologies readily accessible to participating scientists. We expect to identify and target key mediators of brain metastasis, with therapeutic benefit for patients.

PI_NAMEs: HAYDEN GEPHART, MELANIE  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;Advocate;Biology;Brain;brain cell;Brain Neoplasms;Cancer Patient;Clinical;Clinical Trials;Communication;Communities;CRISPR library;Data;data management;Dedications;design;Deterioration;Development;Diagnostic;disease model;Ensure;Exclusion;experience;Experimental Models;Foundations;glycoproteomics;Goals;high throughput screening;Human;human disease;human tissue;Immune system;Immunotherapy;improved;In Vitro;in vivo Model;Incidence;innovation;insight;interest;Interruption;Malignant Neoplasms;Mediator;Metastatic malignant neoplasm to brain;Methods;Microglia;Modeling;Molecular;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;Neuroimmune;Neurologic;neuropathology;new therapeutic target;novel;Office of Administrative Management;organizational structure;Organoids;Patient risk;Patients;Physicians;Primary Neoplasm;Production;Productivity;programs;Quality of life;Research;Sampling;Scientist;Site;Specimen;synergism;Technology;Testing;Therapeutic;therapy resistant;tool;Translating;Translations;Tropism;tumor;tumor microenvironment;Tumor Tissue;Work

PROJECT_TITLE: Deconvolution and interruption of the cancer-neuro-immune axis facilitating brain metastases


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Alternative polyadenylation (APA) is pervasive and expands transcriptome diversity by altering the length/identity of 3’ untranslated regions (3’UTRs) to alter mRNA stability, localization, and translation. However, how APA contributes to erythropoiesis remains to be characterized. This project will identify the patterns of APA during erythropoiesis, the functional consequences of this regulation in key genes, and the molecular mechanisms that drive it in normal human health and disease.

PI_NAMEs: GAZZARA, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 3' Untranslated Regions;Acute Erythroblastic Leukemia;Alternative Splicing;Anemia;Automobile Driving;Binding Proteins;Binding Sites;Biological Assay;Biology;Blood;candidate validation;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Data;Development;Differentiation Antigens;Disease;Distal;Dysmyelopoietic Syndromes;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;erythroleukemic cell;Erythropoiesis;Event;experimental study;GATA1 gene;Gene Expression;gene function;Genes;Genetic Transcription;Goals;Health;Hematopoietic;Human;Immune;insight;Iron;K-562;K562 Cells;knock-down;Knock-out;Knowledge;Length;Location;Luciferases;Maps;Messenger RNA;MicroRNAs;Mitochondria;Molecular;Monitor;mutant;Mutate;Mutation;Northern Blotting;novel;novel therapeutics;Output;Pattern;Play;Poly(A) Tail;Polyadenylation;Prevalence;Process;protein aminoacid sequence;protein expression;Protein Isoforms;Proteins;Proteomics;Race;Regulation;RNA;RNA Processing;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Site;Specific qualifier value;SRSF2 gene;stem cells;TAL1 gene;TCF3 gene;Techniques;Terminator Codon;Thalassemia;Time;Tissues;Trans-Activators;Transcript;transcription factor;transcriptome;transcriptome sequencing;Translations;Validation;Work

PROJECT_TITLE: Mechanisms and consequences of 3'UTR isoform diversity in erythropoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Cancer;Neurosciences

PROJECT_TERMS: Accountability;Adherence;Advocate;Basic Science;Brain;Cancer Patient;Cementation;Collaborations;Communication;Communities;Consultations;Data;Data Analyses;data management;design;Effectiveness;Ensure;Equity;Ethics;Foundations;Future;Generations;Goals;Grant;Human;Human Subject Research;improved;Individual;innovation;Interruption;Malignant Neoplasms;meetings;Metastatic malignant neoplasm to brain;Neuroimmune;next generation;Occupational activity of managing finances;Office of Administrative Management;organizational structure;Participant;Patients;Policies;Postdoctoral Fellow;Process;Productivity;Program Development;programs;Research;Research Design;Research Personnel;Resources;Science;Scientist;Self-Examination;Services;Specimen;Statistical Data Interpretation;statistical service;Structure;success;timeline;Training;Translational Research;Universities;Work

PROJECT_TITLE: Administrative and Data Management Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Exploring the non-coding genome will help open up this vast frontier for the development of novel therapies that could far outreach what biomedical science has been able to accomplish up until now by only targeting the protein-coding genome. In this proposal, we will characterize a novel cancer-associated long non-coding RNA with predicted functions in regulating histone acetylation, Myc signaling, and genome stability. The successful completion of this project will highlight one example of how investigating the non-coding genome can lead to alternative strategies for targeting pathways that are widely considered to be “undruggable,” such as Myc.

PI_NAMEs: CHEN, JASPER R (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;Alleles;Aneuploidy;ANXA5 gene;Apoptosis;Apoptotic;Binding Sites;Biological Assay;Breeding;Bromodeoxyuridine;cancer cell;cancer genome;cancer genomics;cancer survival;cancer therapy;cancer type;career;CASP3 gene;Categories;Cell Cycle;Cell Death Induction;Cell Line;Cell Proliferation;Cell Survival;cell type;Cells;Central Nervous System;Characteristics;ChIP-seq;Chromatin;chromatin isolation by RNA purification sequencing;chromatin remodeling;Clinical;Code;Colcemid;Complex;Development;DNA Damage;Doxycycline;Ensure;Essential Genes;Feedback;frontier;gain of function;Gene Expression;Gene set enrichment analysis;Gene Silencing;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;Genome Stability;Genomic Instability;genotoxicity;Glioblastoma;Glioma;Gliomagenesis;glycogen synthase kinase 3 beta;Goals;Growth and Development function;Histone Acetylation;histone acetyltransferase;Histone H3;Histone H4;Homologous Gene;Impairment;improved;in vivo;Knock-out;Knowledge;loss of function;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Modeling;Mouse Cell Line;mouse model;Mus;Mutagens;Mutation;MYC Family Protein;nestin protein;novel;novel therapeutics;outreach;overexpression;Pathway interactions;Patient-Focused Outcomes;Pattern;Pharmacotherapy;Physicians;PI3K/AKT;PIK3CG gene;Play;Proliferating;promoter;Proteins;PTEN gene;Radiation therapy;recruit;Regulation;Research;Resources;RNA purification;Role;SAGA;Sampling;Science;Scientist;Signal Transduction;Site;T47D;Tamoxifen;targeted treatment;Testis;The Cancer Genome Atlas;Tissues;Training;Transactivation;translational potential;Treatment outcome;tumor;Tumor Burden;Tumor Suppressor Genes;tumorigenesis;Untranslated RNA;Western Blotting;Work

PROJECT_TITLE: Exploration of long non-coding RNAs as synthetic essential targets in Pten-deficient cancers


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: Inflammatory skin diseases are often multifactorial with influences from genetics, such as SNPs in Ovol1, and environmental factors, like irritants in the air, that cause immune dysregulation and impair skin barrier integrity. Neutrophils are the principal innate immune responders forming the first line of defense against pathogenic invader or sterile damages; however, their recruitment requires tight regulation to avoid damage to the host. The proposed research will untangle the early crosstalk between the epidermis and innate immune system, potentially revealing better pharmacological targets to alleviate inflammatory skin disease.

PI_NAMEs: MOSHENSKY, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Ablation;Acne;Acute;Adrenal Cortex Hormones;Air;Animal Model;Animals;Atopic Dermatitis;Biology;Blocking Antibodies;candidate validation;Cells;chemokine;Chemotactic Factors;Collaborations;common treatment;Data;Development;Disease;disease model;Disease Outcome;Disease Progression;Embryo;Environmental Hazards;Environmental Risk Factor;Enzymes;Epidermis;ERG gene;extracellular;Family;Flow Cytometry;Gatekeeping;gene repression;Genes;Genetic;genome wide association study;Glutathione S-Transferase;Homeostasis;Homologous Gene;Hour;Image;Immune;Immune response;Immune system;Immunity;Immunology;immunoregulation;Impairment;improved;Inflammation;Inflammatory;inhibitor;injured;Injury;Innate Immune System;interdisciplinary approach;intravital imaging;intravital microscopy;Irritants;Knockout Mice;Label;Lasers;Lesion;Leukotriene C4;Leukotriene Production;Leukotrienes;Link;lipid mediator;Lipids;Mass Spectrum Analysis;Microsomes;Minor;multidisciplinary;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;overexpression;pathogen;Pathogenicity;Peptide Hydrolases;pharmacologic;Play;prevent;Production;Psoriasis;Reactive Oxygen Species;recruit;Regulation;Reporting;Research;Retinoids;Role;Running;side effect;single-cell RNA sequencing;Site;Skin;skin barrier;skin damage;skin disorder;Skin injury;Sterility;System;Systems Biology;transcription factor;Transcription Repressor;transcriptome sequencing;wound;Zinc Fingers

PROJECT_TITLE: Disentangling the Epidermal Immune Crosstalk in Inflammatory Skin Disease


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Precision Medicine;Prevention;Radiation Oncology

PI_NAMEs: JI, HANLEE P (contact)

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Anti-CD47;biobank;Biological;Biological Models;Brain;brain cell;Brain Neoplasms;cancer genome;cancer type;cell type;Cells;Cellular Tropism;Characteristics;Clinical;Computer Models;Data;Data Set;differential expression;Disease Progression;Early Diagnosis;Foundations;functional status;Genes;genomic biomarker;genomic data;Genomic Instability;genomic predictors;genomic signature;Genomics;Goals;Growth;high risk;imaging modality;Immune;Immunologic Surveillance;in vitro testing;Incidence;insight;Interruption;Link;Macrophage;Magnetic Resonance Imaging;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Microglia;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;Mutation;Neoplasm Metastasis;Neuroimmune;Neurologic;neuropathology;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;Patients;Peripheral;Play;Prediction of Response to Therapy;predictive marker;predictive modeling;pressure;Primary Neoplasm;Prognostic Marker;programs;Radiation;Radiation therapy;Radiation Tolerance;radioresistant;Recording of previous events;Resected;Resources;response;Risk;Role;Sampling;screening;Selection for Treatments;single cell genomics;standard of care;Statistical Models;Testing;translational study;Treatment Efficacy;Treatment outcome;treatment response;Tropism;tumor;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Determine the mechanisms of acquired brain-tropism


ADMINISTERING_IC: FD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Washington, DC

ORG_NAME: REAGAN-UDALL FOUNDATION/FOOD/DRUG/ADMIN

ORG_STATE: DC

PHR: Effective engagement with the public is essential to expand the impact of the Food and Drug Administration, and for the efficient transfer of information and insights among the agency, patients, academia, consumers and regulated industry. With this cooperative agreement award, the Reagan-Udall Foundation for the FDA will initiate and support projects that enable critical public health collaborations among FDA, industry, and the public. The Foundation will leverage its expertise and experience in areas of regulatory science, real-world data, patient and consumer engagement, and expanded access to deliver a suite of programs that enhance FDA’s mission.

PI_NAMEs: BHAT, AMARNATH  (contact)

PROGRAM_OFFICER_NAME: ORR, ROBERT

PROJECT_TITLE: SPARC: Supporting Patient Access, Real-world data, and critical Collaborations


PROJECT_TERMS: 3-Dimensional;Affect;Air;Animal Model;Anti-CD47;Antigen Presentation;Architecture;Biological Assay;Bone Marrow Transplantation;Brain;Brain Neoplasms;Busulfan;cancer cell;CD47-SIRPα;Cell Communication;Cell Death;Cells;Cerebrospinal Fluid;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;CRISPR library;CSF1 gene;cytokine;Data;Disease Progression;Disseminated Malignant Neoplasm;Distant;Epithelium;Evaluation;Exhibits;Extracellular Matrix;Gene Modified;Generations;Genes;Growth;Human;human disease;Immune;immune cell infiltrate;Immunologic Surveillance;Immunological Models;Immunotherapy;implantation;in vitro Model;Inflammatory;Inflammatory Response;innovation;Interleukin-6;Interruption;Intrinsic factor;Invaded;Knock-out;Knowledge;Ligands;Liquid substance;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Metalloproteases;Metastatic malignant neoplasm to brain;Methods;Microglia;migration;Modeling;Monitor;mortality;multidisciplinary;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Neuroimmune;Neurologic;neuropathology;novel;novel strategies;Organoids;Phagocytosis;Phenotype;Population;Positioning Attribute;Primary Neoplasm;Production;Prognosis;Proliferating;Property;Protocols documentation;Publishing;receptor;Recurrence;Resistance;RNA analysis;Role;Sampling;Signal Transduction;single-cell RNA sequencing;small molecule;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;transcriptome;tumor;Tumor Cell Invasion;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;weapons

PROJECT_TITLE: Investigate and inhibit microglia support of brain metastases


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: RELEVANCE (See instructions): Social anxiety disorder (SAD) is one of the most prevalent mental disorders, affecting 12.1% of U.S. individuals at some point in their lifetime. SAD is characterized by fear and avoidance of socially evaluative situations, often leading to devastating consequences for the affected individual and placing considerable economic burden on society at large.

PI_NAMEs: BARNES, LAURA ELIZABETH (contact);BOUKHECHBA, MEHDI O.;TEACHMAN, BETHANY A

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: adaptive intervention;Affect;Anxiety;anxiety states;anxious;anxious individuals;Awareness;biomarker identification;biomarker signature;care seeking;Cellular Phone;Clinical Trials;Collaborations;cost effective;Data;Dose;Economic Burden;Exhibits;Feedback;Fright;Future;Impairment;Individual;Instruction;Intervention;intervention delivery;Interview;iterative design;Life;Life Experience;Mental disorders;Mental Health Services;Methods;mobile sensing;Modeling;Participant;personalized intervention;Persons;Phase;Physiological;Pilot Projects;Population;Positioning Attribute;predictive signature;psychological stressor;Quality of life;recruit;reduce symptoms;Research;response;Sampling;sensor;Services;smart watch;social;social anxiety;Social Anxiety Disorder;Social Environment;Social Hierarchy;social interventions;Societies;stressor;System;therapy development;Time;treatment optimization;Universities;university student;user centered design;Work;young adult

PROJECT_TITLE: SCH: INT: Context-Aware Micro-Interventions for Social Anxiety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Dissemination and Implementation Research;Genetics;Human Genome;Patient Safety;Precision Medicine

ORG_DEPT: GENETICS

PHR: 8. Project Narrative Drug response is inherited in much the same way as other traits like height, hair color, and the risk for some diseases. Pharmacogenomics studies how human genetic (DNA) variation influences the response to drugs. The Clinical Implementation Resources for Pharmacogenomics (CIRP) aims to facilitate clinical implementation of pharmacogenomics by creating and disseminating gene/drug clinical guidelines and are then used to annotate an individual’s genotypes issuing a report for the clinician.

PI_NAMEs: CAUDLE, KELLY E.;KLEIN, TERI ELLEN (contact);RITCHIE, MARYLYN D

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Academic Medical Centers;Acceleration;Adoption;Adverse drug event;adverse drug reaction;Adverse effects;Alleles;annotation  system;Catalogs;Cessation of life;Clinic;Clinical;clinical development;clinical implementation;clinical practice;cloud based;cloud platform;Collaborations;Communities;cost;Coupled;Data;Discipline;Disease;DNA;DNA Sequence;drug efficacy;drug modification;Education and Outreach;Effectiveness;Ensure;Environment;evidence base;FDA approved;Funding;Future;Genes;Genetic;genetic testing;genetic variant;Genetic Variation;Genome;genome resource;Genomic medicine;Genomics;Genotype;genotyped patients;Germ Lines;Guidelines;Hair Color;Haplotypes;health care service organization;Healthcare;Height;Hospitalization;Human Genetics;implementation efforts;implementation tool;improved;Individual;Infrastructure;Inherited;innovation;Institution;International;Intervention;Investments;Knowledge;knowledgebase;Language;Measures;Medicine;Mission;Myopia;National Human Genome Research Institute;novel therapeutics;Patients;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Phenotype;Physiological;precision medicine;preventable death;programs;Provider;Publishing;Recommendation;Reporting;Research;Resources;response;Rest;Risk;Safety;Software Tools;Source;Specific qualifier value;Standardization;Structure;success;Surveys;Test Result;Testing;tool;tool development;trait;Translating;Translations;United States;United States National Institutes of Health;Update;uptake;user friendly software;Variant;working group


NIH_SPENDING_CATS: Cancer

ORG_CITY: HANOVER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative POWERED is designed as a significant experience in cancer research for students from groups that are underrepresented in professional cancer research. The students will be recruited from the 10-college network, NH-INBRE and will participate in a program with 2 summers of full time research at Norris Cotton Cancer Center, and 4 semesters of part time research at their home institution. The goal is to establish these students on a path to becoming professional cancer researchers.

PI_NAMEs: FIERING, STEVEN  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Advisory Committees;anti-cancer research;Attention;Awareness;Basic Science;Biomedical Research;Cancer Burden;Cancer Center;career;Catchment Area;Clinical;Clinical Research;cohort;college;Communication;Community Outreach;Decision Making;design;Development;Device or Instrument Development;Drug Targeting;Ecosystem;Education;education research;Ethics;Evaluation;experience;Exposure to;Faculty;Foundations;Funding;Future;Goals;graduate student;Home;Immunology;Individual;innovation;Institution;interest;Knowledge;Laboratories;Leadership;Learning;Life;Malignant Neoplasms;Measures;Medical Students;member;Mentors;minority undergraduate;multimodality;Nanotechnology;National Institute of General Medical Sciences;New Hampshire;next generation;Norris Cotton Cancer Center;Oncology;oncology program;outreach;Participant;Pharmaceutical Preparations;Physicians;Population Sciences;Postdoctoral Fellow;Professional Competence;programs;Qualifying;recruit;Research;Research Personnel;resilience;Rural;Scientist;Secure;skills;Source;Structure;Student Selections;Students;success;Time;tool;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Program for Oncology Workforce Education and Research Experience at Dartmouth

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Skin Cancer;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Vaccine Related

PI_NAMEs: LIM, MICHAEL  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Adoptive Transfer;Air;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antitumor Response;Autologous;Biological Assay;Brain;Brain Drains;Brain Neoplasms;Breast;Breast Cancer Cell;cancer cell;Cancer cell line;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Cephalic;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;Distal;draining lymph node;Drops;Exhibits;Flow Cytometry;Future;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;induced pluripotent stem cell;Infiltration;inhibitor;Injections;insight;Interferon Type II;Interruption;Intracranial Neoplasms;ITGAM gene;Kidney;Knock-out;Knockout Mice;Lesion;Liquid substance;Lung;lung cancer cell;lymph nodes;Lymphocyte;Malignant Neoplasms;Measurement;Measures;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Metastatic Melanoma;migration;Modeling;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Neoplasm Metastasis;Neuroimmune;novel;Organoids;Pathologic;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized immunotherapy;Positron-Emission Tomography;Production;Prognosis;Proliferating;reconstitution;recruit;Role;Signal Transduction;Site;Skin;spatiotemporal;Specimen;Splenocyte;subcutaneous;synergism;T cell clonality;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;Transforming Growth Factor beta;Transgenic Mice;treatment strategy;Tropism;tumor;tumor progression;Tumor-associated macrophages;Vaccinated;Vaccination;vaccination strategy;Vaccines

PROJECT_TITLE: Optimizing systemic immunotherapy for personalized brain metastasis treatment


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it represents a novel approach of using engineered bacteria that can colonize the entire gut and express a desired function for long periods of time. The investigators will use this innovative strategy to engineer microorganisms that help prevent colorectal cancer formation. Thus, the proposed research is relevant to the part of NCI's mission to improve health by the development and accel- eration of the synthetic biology approaches to the understanding, diagnosis, and treatment of colorectal cancer in those who are particularly at risk.

PI_NAMEs: ZARRINPAR, AMIR  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Acceleration;Address;adenoma;Affect;Age;Animal Genetics;Animal Model;anti-cancer research;Attenuated;Bacteria;Bile Acids;Biological Response Modifier Therapy;Biosensor;Black American;Cancer Biology;Cancer Detection;Cancer Etiology;cancer therapy;Caspase;Cells;Cessation of life;Colon;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;colorectal cancer screening;colorectal cancer treatment;Data;demographics;Development;Diagnosis;Disease;Disease Progression;Early identification;early onset colorectal cancer;Engineering;Engraftment;Environment;epidemiology study;Escherichia coli;Familial Adenomatous Polyposis Syndrome;Gene Expression;Genetic Engineering;Genetic Models;Genetic Predisposition to Disease;Goals;Growth;gut microbiota;Health;high risk population;host colonization;host-microbe interactions;improved;Incidence;Inflammatory Bowel Diseases;innovation;Interdisciplinary Study;interest;Knowledge;Malignant Neoplasms;mathematical model;Methods;microbial composition;microbiome;microbiome therapeutics;Microfluidic Microchips;microorganism;Mission;Modeling;Monitor;Mus;novel;novel strategies;organ on a chip;Organoids;Outcome;Peptide Hydrolases;Performance;Population;Population Dynamics;prevent;Prevention;Protease Inhibitor;Proteins;Proteomics;Public Health;receptor;Reporter;Reporting;Research;Research Personnel;response;Risk;Role;Scientist;sensor;Signal Transduction;synthetic biology;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Uses;Time;Tissues;tool;trait;translational impact;tumor;tumor microenvironment;tumor progression;vector;Visualization;Work

PROJECT_TITLE: Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Pancreatic cancer, one of the deadliest human malignancies, is characterized by extensive accumulation of desmoplastic stroma. Cancer Associated Fibroblasts (CAFs) are a prevalent component of the stroma, yet their nature and function are poorly understood. Here, we will elucidate mechanisms of CAF reprogramming in pancreatic cancer and map CAFs across tumors of patients of different races and ethnicity, addressing critical gaps in our understanding of the human disease.

PI_NAMEs: CRAWFORD, HOWARD C.;FRANKEL, TIMOTHY LOUIS;LYSSIOTIS, COSTAS ANDREAS;PASCA DI MAGLIANO, MARINA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;advanced disease;Affect;African American;Area;Atlas of Cancer Mortality in the United States;Biological;cancer cell;Cancer Etiology;cancer therapy;carcinogenesis;Cells;Cessation of life;Characteristics;Chemoresistance;Classification;Coculture Techniques;cytokine;Cytokine Gene;Data;Desmoplastic;Diagnosis;Disease;Eligibility Determination;Epithelium;Ethnic Origin;Evolution;Excision;Fibroblasts;Gene Expression Profile;Genes;Genetic Transcription;Genetically Engineered Mouse;Growth;Health system;Heterogeneity;Histologic;Human;human disease;Immune;Immune response;In Vitro;in vivo;Infiltration;Inflammatory;Investigation;KRAS oncogenesis;KRAS2 gene;Ligands;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Mesenchymal;Metabolic;Michigan;Minority;Modeling;molecular subtypes;Mus;mutant;Mutation;Nature;neoplastic cell;new therapeutic target;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Organoids;Pancreas;pancreatic cancer model;pancreatic cancer patients;pancreatic tumorigenesis;patient population;Patients;Population;Predisposition;programs;Race;racial population;Recurrence;Regulation;Role;Signal Pathway;Signal Transduction;skills;standard of care;STAT3 gene;Target Populations;Testing;therapy resistant;tumor;Tumor Subtype;Tumor Suppressor Proteins;Tumor Volume;Tumor-associated macrophages;Tumor-infiltrating immune cells;Universities;Work

PROJECT_TITLE: Fibroblast orchestration of the immune response in pancreatic cancer


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: KUO, CALVIN J (contact)

PROJECT_TERMS: 3-Dimensional;Address;Air;Anti-CD47;Area;Automobile Driving;Biological;Biological Assay;Brain;Brain Neoplasms;brain tissue;Cancer Model;candidate identification;Cause of Death;cell motility;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;CRISPR library;CRISPR screen;CRISPR/Cas technology;cytokine;Development;Disease;empowerment;Engineering;Epithelial Cells;Epithelium;experience;experimental study;functional genomics;Genetic;Genetic Screening;Genomics;glycoproteomics;glycosylation;Goals;Human;Immune;improved;In Vitro;in vitro Model;induced pluripotent stem cell;Information Dissemination;innovation;insight;Interruption;Invaded;Investigation;Knock-out;Libraries;Life;Liquid substance;Lymphoid;Malignant Neoplasms;Mass Spectrum Analysis;Metastatic malignant neoplasm to brain;Microglia;migration;Modeling;Molecular;Molecular Profiling;Mus;Neoplasm Metastasis;neoplastic cell;Neuroimmune;neuropathology;new technology;next generation;novel;Occupational activity of managing finances;Organism;Organoids;Pathway interactions;Patients;Pattern;Peptides;Phagocytes;Physiological;Play;Positron-Emission Tomography;Post-Translational Protein Processing;preservation;Production;Proliferating;Protein Analysis;Protein Glycosylation;Proteome;Proteomics;Qualifying;radiation response;reconstitution;Research;Resources;response;Sampling;Scientist;Signal Transduction;Study models;Survival Rate;synergism;T-Lymphocyte;Techniques;Technology;Therapeutic;Tissue Banks;Tissues;tool;transcriptomics;tumor;Tumor-Associated Process;tumor-immune system interactions;vaccine development;vaccine strategy;Vision

PROJECT_TITLE: TOOLKIT Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE: “Handoffs and Transitions in Critical Care – Understanding Scalability (HATRICC-US)” There exists a critical gap in knowledge about effective implementation strategies in the context of critical care, resulting in a performance gap that compromises outcomes for critically ill patients. This project seeks to elucidate and overcome challenges to implementation in the acute care setting for patients with postoperative cardiopulmonary failure, integrating engineering and implementation science approaches to study the implementation of post-surgical handoff protocols. This project is poised to have substantial public health impact by advancing our understanding of effective implementation strategies in the acute care setting.

PI_NAMEs: LANE-FALL, MEGHAN BROOKS (contact)

PROGRAM_OFFICER_NAME: PLEVOCK HAASE, KAREN MARIE

PROJECT_TERMS: Acute;acute care;Address;Adherence;Admission activity;Adoption;Adult;Adverse event;American Heart Association;Area;base;Cardiopulmonary;Caring;Case Study;Center for Translational Science Activities;Chronic Disease;Communication;Complement;Complex;Continuity of Patient Care;cost;Critical Care;Critical Illness;design;digital;Disease;effective intervention;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation study;Engineering;Ensure;Environment;Evaluation;Event;evidence base;Evidence based intervention;Failure;Goals;guided inquiry;Health system;Healthcare;Hospitals;human centered design;Hybrids;implementation cost;implementation determinants;implementation efforts;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation study;implementation trial;improved;inpatient surgery;Intensive Care Units;Intervention;Knowledge;Leadership;Life;Maps;Measures;Medical center;Methods;Modeling;Modernization;National Heart, Lung, and Blood Institute;Operating Rooms;Operative Surgical Procedures;Organ failure;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pediatric Intensive Care Units;Performance;Postoperative Period;pragmatic study;pragmatic trial;preservation;prevent;primary outcome;Process;Protein Structure Initiative;Protocols documentation;Provider;Public Health;Publishing;Randomized;Resources;satisfaction;Site;Social Marketing;Standardization;State Interests;theories;Translating;trial design;United States;United States Agency for Healthcare Research and Quality;uptake;usability;Visit;Visual;Work;Workload

PROJECT_TITLE: Handoffs and Transitions in Critical Care - Understanding Scalability

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative: We propose to develop optogenetic and chemigenetic tools to visualize and control the metabolism of single mRNAs with high spatiotemporal resolution in live cells. We will use the tools to investigate the molecular mechanism of RNA decay and localized translation. The experimental tools will be valuable for studying post-transcriptional gene expression which is important to decipher the molecular mechanism of neural development, learning and memory formation, and to develop therapeutic treatment for neurological diseases.

PI_NAMEs: WU, BIN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Anterior;axon growth;beta Actin;Binding;Biological;Biological Process;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Cytoplasmic Granules;Dendrites;Dendritic Spines;Development;developmental disease;DNA;Essential Genes;Face;Fibroblasts;Gene Expression;Gene Expression Regulation;Genes;genetic approach;Genetic Transcription;Goals;Growth Cones;Guide RNA;Hour;image translation;in vivo;Kinetics;knock-down;Knock-out;Label;Lasers;Learning;Light;Lighting;Logic;Memory;Messenger RNA;Metabolism;Methods;Microscopy;Molecular;Monitor;mRNA Translation;Nervous System Disorder;neurodevelopment;neuromechanism;neuronal growth;Neurons;nuclease;Nucleotides;Oocytes;Optics;optogenetics;Pathway interactions;Play;Post-Transcriptional Regulation;posttranscriptional;Process;Protein Biosynthesis;Proteins;Protocols documentation;Reagent;recruit;Regulation;Reporter;Research;Resolution;RNA;RNA Decay;RNA Degradation;RNA Editing;RNA Interference;RNA metabolism;RNA Probes;RNA Processing;RNA Stability;RNA-Binding Proteins;Role;single molecule;small hairpin RNA;Small Interfering RNA;small molecule;spatiotemporal;Speed;Technology;temporal measurement;Testing;Therapeutic;Time;tool;Transfection;Translating;translation assay;Translational Repression;Translations;Untranslated RNA;Visualization;Work

PROJECT_TITLE: Developing optogenetic and chemogenetic approaches to control RNA metabolism in live cells

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Neurosciences;Radiation Oncology

PI_NAMEs: PETRITSCH, CLAUDIA KATHARINA (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adherent Culture;Archives;Area;ATAC-seq;Blood Vessels;blood-brain barrier permeabilization;Brain;brain surgery;Breast;cancer biomarkers;Cancer Patient;cancer type;Cell Line;cell type;Cells;Cerebrospinal Fluid;checkpoint inhibition;Clinical;Clinical Trials;clinically relevant;Clonal Evolution;Collaborations;Collection;Complement;Consent;Data;data management;Development;Disease;Dissociation;Distant;Excision;Exhibits;Frequencies;Fresh Tissue;Gene Expression Profile;genome sequencing;Genomics;Grant;Growth;Heterogeneity;Image;Immune;Immune checkpoint inhibitor;Immune system;Immunosuppression;Immunotherapy;immunotherapy clinical trials;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infiltration;insight;Institution;Interruption;Intracarotid;Length;Lung;Malignant - descriptor;Malignant neoplasm of brain;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Melanoma;Metastatic malignant neoplasm to brain;metastatic process;Microglia;model development;Modeling;Molecular;Molecular Profiling;molecular targeted therapies;monocyte;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mutation;Myeloid-derived suppressor cells;nano-string;Neoplasm Metastasis;neoplastic cell;Neuroglia;Neuroimmune;neuropathology;Neurosphere;next generation sequencing;Office of Administrative Management;Operative Surgical Procedures;Pathway interactions;Patients;peripheral blood;Pre-Clinical Model;Preclinical Testing;predictive marker;Primary Neoplasm;prognostic;Prognostic Marker;Proliferating;Quality Control;Radiation;radiation response;Radiation therapy;Radiology Specialty;repository;Research;Research Personnel;Resistance;Resources;response;Risk;Role;Sampling;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Solid;Solid Neoplasm;Specimen;stemness;Stress;T cell infiltration;T-Lymphocyte;tissue archive;Tissue Banks;tissue fixing;Tissue Microarray;Tissues;tool;Transforming Growth Factor beta;treatment and outcome;Tumor-associated macrophages;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: NEUROPATHOLOGY/TISSUE BANK CORE


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Retinal pigment epithelial (RPE) cells have unique metabolic requirements that are perturbed in disease states, such as age-related macular degeneration (AMD). Findings from our studies will provide a framework for understanding how induced pluripotent stem cell derived RPE can be used to model metabolic changes leading to AMD pathogenesis. These studies will expedite the understanding of the underlying causes of RPE- related disease and facilitate treatment discovery.

PI_NAMEs: CHAO, JENNIFER RAYMING (contact);DU, JIANHAI

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Adult;Affect;Age related macular degeneration;Awareness;Biological Models;Blindness;Blood;cancer cell;Cell Culture Techniques;Cell Differentiation process;cell growth;Cell Line;Characteristics;Complement;Consensus;Consumption;CRISPR correction;Culture Media;Data;Deposition;design;Development;dichlorodifluoromethane;Disease;disease phenotype;Drusen;early onset;Elements;Energy Metabolism;Environment;Epithelial Cells;Experimental Designs;extracellular;Eye diseases;Future;Gender;Genes;Genus Hippocampus;Glycolysis;Goals;high risk;Human;human old age (65+);In Vitro;Individual;induced pluripotent stem cell;Knowledge;Laboratories;lipid metabolism;macular drusen;Maintenance;matrigel;Measures;Mendelian disorder;Metabolic;Metabolic dysfunction;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;Mutation;Nutrient;Outcome;Oxygen saturation measurement;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Physiological;Play;Preparation;Regulation;Reporting;Reproducibility;Resources;Retinal Diseases;risk variant;RNA Splicing;Role;stem cells;Structure;Structure of retinal pigment epithelium;System;therapeutic target;Tight Junctions;United States National Institutes of Health;Variant;Visual impairment;Vitronectin

PROJECT_TITLE: Metabolism of AMD iPSC-derived RPE


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Pediatric;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: University of Minnesota Cancer Research And Teaching Excellence: M-CREATE is a theoretically guided, evidence driven program designed to support the academic persistence of high school and undergraduate students underrepresented in science, and promote their developmental progress towards future careers in cancer research. M-CREATE will combine best practices with innovative approaches from education, mentorship, service learning, and parent education within an equity-oriented frame to engage, educate, and support students to achieve the knowledge, skills, science identity, and self-efficacy required to support academic persistence and long-term success within the biomedical and behavioral sciences. Diversifying the cancer research workforce is critical to addressing the pressing needs of increasingly diverse patient populations in Minnesota and across the U.S.

PI_NAMEs: ALLEN, MICHELE L (contact);PENNELL, CHRISTOPHER A

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academic support;Achievement;Address;African American;African American population;anti-cancer research;Applied Skills;Area;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Research;Cancer Center;cancer health disparity;Cancer health equity;career;career development;Child Rearing;Cognitive;cohort;Color;Communities;community advisory board;community engagement;design;Development;Disparity;Education;education research;Educational Activities;Educational Curriculum;Educational Models;Educational process of instructing;Ensure;Equity;Evaluation;evidence base;experience;Future;Goals;Graduation Rates;hands on research;Health;Health Disparities Research;Health Status;high school;High School Faculty;High School Student;Home;Immigrant;innovation;Knowledge;laboratory experience;Latinx;Leadership;Malignant Neoplasms;Mentors;Mentorship;Methods;Minnesota;Native Americans;Outcome;Parenting Education;Parents;patient population;Process;programs;Recording of previous events;Research;Research Methodology;Research Personnel;school district;Schools;Science;Scientist;Self Efficacy;service learning;skill acquisition;skills;social;Student Persistence;Students;success;summer program;systemic barrier;teacher;teacher community;Teacher Professional Development;theories;Time;Twin Cities;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;urban school;Youth


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Hematology;Orphan Drug;Pain Research;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Pain is the hallmark of sickle cell disease (SCD), and is the leading cause of hospitalizations, emergency room visits, missed school, and is associated with an increased death rate. We found that patients with SCD and pain had low levels of the amino acid arginine in their blood, and we also demonstrated that arginine supplementation during acute pain events signiﬁcantly reduced the amount of narcotics needed to treat sickle cell pain in children and dramatically improved pain scores at discharge compared to placebo. We propose to investigate the beneﬁts and safety of arginine for the treatment of patients with SCD and pain in a phase 3 randomized, placebo-controlled clinical trial where neither the patient nor the clinical team know which therapy the patient is receiving, since Arginine is a promising new therapy that could change the way we treat acute pain in SCD.

PI_NAMEs: CASPER, THERON C (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Absence of pain sensation;Accident and Emergency department;Acute;acute care;Acute Pain;Affect;African American population;aged;Amino Acids;Area;arginase;Arginine;arginine treatment;Biological;Biological Availability;Biometry;Blood;Blood Cells;Blood Vessels;Cell Adhesion Molecules;Cell Density;Child;Child Care;Childhood;Clinical;clinical practice;clinical trial analysis;Clinical Trials;clinically relevant;Communication;Complex;Data;Data Collection;Data Coordinating Center;data management;Data Set;Death Rate;design;Dose;Double-Blind Method;double-blind placebo controlled trial;Down-Regulation;Drug Kinetics;efficacious intervention;efficacy evaluation;efficacy testing;Electrons;Emergency department visit;emergency settings;Erythrocytes;Event;experience;Goals;Hemolysis;Hemolytic Anemia;Hospitalization;Hospitals;Hour;Human Resources;Hydration status;improved;Individual;Inflammatory;Inherited;Inpatients;Intervention;Leadership;Length of Stay;lung injury;Maintenance;Manuals;metabolome;Mitochondria;mitochondrial dysfunction;Monitor;mortality;mouse model;Narcotics;neglect;new therapeutic target;Nitric Oxide;novel therapeutics;operation;opioid use;oxidation;Pain;pain score;Pathway interactions;Patient Admission;Patient Care;Patients;pediatric emergency;Perfusion;Phase;phase III trial;Physiology;Placebo Control;Placebos;Plasma;Platelet Aggregation Inhibition;pleiotropism;Preparation;primary endpoint;product development;Production;Protocols documentation;Qualifying;Randomized;randomized placebo-controlled clinical trial;Reperfusion Injury;Reporting;Research;Research Personnel;Resolution;Safety;safety testing;Schools;Sickle Cell;Sickle Cell Anemia;Specimen;standard of care;Supplementation;Syndrome;Technical Expertise;Testing;Therapy trial;Time;Training;Transgenic Mice;trend;Universities;Utah;vaso-occlusive pain;Vasodilator Agents;ward

PROJECT_TITLE: 2/2: Sickle Cell Disease Treatment with Arginine Therapy (STArT) trial


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Automated docking has become a widely used technique for structure based rational drug design, and AutoDock, the most cited docking software tool with a large user base, is a key resource for the rationalization or design, and optimization of drug receptor interactions. Keeping this software running on evolving hardware and operating systems requires maintenance. We propose the creation of a national resource to maintain and modernize the software, for supporting the growth of a community of open source developers towards a self-sustained software resource, and for augmenting our user training efforts.

PI_NAMEs: FORLI, STEFANO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;algorithm development;Award;base;Biological;Biomedical Computing;Clinical;Cloud Computing;Code;Communities;computational pipelines;Computer Hardware;Computer software;Computing Methodologies;computing resources;crowdsourcing;Data;design;Development;Docking;Documentation;Drug Design;drug discovery;Drug Receptors;Ecosystem;Education;Educational process of instructing;Educational workshop;Ensure;file format;Funding;Goals;Grant;graphical user interface;Growth;improved;Individual;interest;interoperability;Intuition;Ligands;Maintenance;Metadata;Methods;migration;Modeling;Modernization;molecular dynamics;NIH Program Announcements;novel therapeutics;open source;Operating System;Peer Review;Periodicals;Persons;Pharmaceutical Preparations;Physicians;Positioning Attribute;Process;programs;Pythons;Rationalization;Reproducibility;Research;Research Personnel;Resources;Review Literature;Running;scale up;skills;small molecule;small molecule libraries;software development;Software Engineering;Software Tools;Structure;success;symposium;Techniques;Technology;Teleconferences;Testing;tool;Training;Update;usability;video chat;virtual screening;webinar;Work;Writing

PROJECT_TITLE: Resource for Structure-based Computational Drug Discovery and Design (RSD3)


ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE An emphasis on training and career development of physician-scientists is critical to maintaining and improving the biomedical workforce, as the number of physicians who conduct scientific research has been in decline in recent decades. The Southeastern Medical Scientist Symposium (SEMSS) will provide a venue to foster connections, enhance training, and provide leadership opportunities for MD/PhD students at multiple institutions across the Southeast. Additionally, the SEMSS will foster excitement among undergraduate students, particularly from underrepresented in medicine backgrounds, about careers in academic medicine, with the ultimate goal of increasing the pipeline of future physician-scientists.

PI_NAMEs: YACOUBIAN, TALENE ALENE (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: African American;Alabama;American;Area;Award;Black Populations;career;career development;Chicago;cost;COVID-19 pandemic;Development;Doctor of Philosophy;doctoral student;educational atmosphere;Event;Exposure to;Faculty;Female;Fostering;Funding;Future;Goals;graduate school;Hispanic;Historically Black Colleges and Universities;Home;improved;Institution;Interdisciplinary Education;interest;Latinx;Leadership;Location;Louisiana;Medical;Medical center;medical schools;Medical Students;Medicine;meetings;Mentors;Mississippi;Oral;Outcome;Participant;Persons;Physicians;posters;programs;Research;Rotation;Scientist;social;South Carolina;student conference;student participation;Students;success;symposium;Tennessee;Training;Training Programs;Travel;trend;undergraduate student;United States;United States National Institutes of Health;Universities;university student;virtual


PHR: Overall – Project Narrative The Vision Research Core Grant (VRC) enhances the NEI R01 funded research programs of 25 investigators plus more than 10 other vision scientists at the University of Washington who work to characterize fundamental mechanisms of the healthy visual system and how disease affects these mechanisms. The VRC accomplishes this by providing services, shared equipment, and technical expertise that are not available and cannot be obtained through individual grants. The core promotes collaborations among members of the vision science community at the University of Washington and others worldwide.

PI_NAMEs: NEITZ, MAUREEN E (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Award;Behavior;Biology;Blindness;Cellular biology;Chemistry;circadian biology;Collaborations;Communities;computational neuroscience;Contract Services;Core Grant;Developmental Biology;Discipline;Disease;Electrophysiology (science);Equipment;equipment acquisition;Functional Imaging;Funding;gene therapy;Genetic;Goals;Grant;Histology;Human Resources;Immunology;in vivo;Individual;instrumentation;investigator training;Laboratories;member;Mentors;Metabolism;Microscopy;Molecular and Cellular Biology;Molecular Biology;National Eye Institute;ocular imaging;Perception;Photoreceptors;Physiology;Prevention;programs;Qualifying;Recording of previous events;recruit;Research;research faculty;Research Personnel;Resources;Retina;Scientist;Services;skills;square foot;success;Technical Expertise;Testing;Training;United States National Institutes of Health;Universities;Vision;Vision research;vision science;Visual System;Washington;Work

PROJECT_TITLE: Vision Research Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PI_NAMEs: WONG, RACHEL O (contact)

PROJECT_TITLE: Microscopy and Histology Core Module


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Given the prevalence and disproportionate mortality associated with Basal-like Breast Cancer (BLBC) compared to other breast cancer subtypes, investigating its biology is of paramount importance to women’s health. This proposal investigates the BLBC founder cell and the aberrant dedifferentiation that promotes cellular plasticity and treatment resistance. Findings from these studies will enhance our understanding of gene regulatory networks responsible for multipotency reactivation in the adult mammary gland and could lead to advancements in the treatment of highly plastic malignancies.

PI_NAMEs: LARIOS-VALENCIA, JESSIE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Ablation;Adult;Aggressive Clinical Course;Biology;BRCA1 gene;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer subtypes;Candidate Disease Gene;Cell Transplantation;Cells;Chromatin;college;Complement 3a;Data;Data Analyses;Development;DNA Binding;effective therapy;Embryo;Embryonic Development;Enhancers;Environment;Epithelial Cells;Epithelium;experimental study;follow-up;Future;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Engineering;Genetic Transcription;Gland;Goals;Heterogeneity;Homeostasis;Human;Hyperplasia;improved;in vivo;Lesion;Literature;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Maps;Medicine;Mentorship;Modeling;Molecular;mortality;mouse model;Multipotent Stem Cells;Mus;Mutation;novel;Oncogenic;Paper;Pathway interactions;Physicians;Population;Precancerous Conditions;Predisposition;premalignant;Prevalence;Process;progenitor;Prognosis;Proliferating;Research;Resolution;RNA;Role;Scientist;single-cell RNA sequencing;skills;stem cell biology;stem cell population;stem cells;synergism;targeted treatment;Testing;Therapeutic;therapy resistant;TP53 gene;Training;Transcription Factor AP-1;Transitional Cell;Transplantation;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Undifferentiated;Up-Regulation;Women's Health;Work

PROJECT_TITLE: The Role of Dedifferentiation in Basal like Breast Cancer


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision

PI_NAMEs: HURLEY, JAMES BRYANT (contact)

PROJECT_TERMS: Cell Culture Techniques;Charge;Collaborations;Dependovirus;design;Dideoxy Chain Termination DNA Sequencing;DNA sequencing;Documentation;Equipment;Gel;gel electrophoresis;Human Resources;Individual;instrument;Methods;Molecular and Cellular Biology;plasmid DNA;Polymerase Chain Reaction;Productivity;programs;Research;Research Personnel;Resource Sharing;Resources;Scientist;Site-Directed Mutagenesis;Spectrophotometry;System;Technical Expertise;Technology;Time;Vision;Vision research;vision science;Water Purification

PROJECT_TITLE: Molecular and Cellular Biology Module


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: NEITZ, JAY  (contact)

PROJECT_TERMS: Calibration;Collaborations;cost effective;Data Analyses;design;Electrophysiology (science);Equipment;experimental study;Eye;Human Resources;imaging capabilities;in vivo;Individual;instrument;Methods;Modernization;ocular imaging;Physiological;Productivity;programs;Psychophysics;Research;Research Personnel;Resource Sharing;Resources;Scientist;Technical Expertise;Technology;time use;Vision;Vision research;visual stimulus;Visual System;visual tracking

PROJECT_TITLE: Functional Analysis of the Visual System and In Vivo Ocular Imaging Module


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Lung;Lung Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The project is relevant to the NIH’s mission and to public health because successful completion of this work will finally unveil the decade-long promise of using small RNAs as anti-cancer agents. Here we will generate small RNA delivery vehicles with exceptional specificity and improved pharmacokinetics along with a fully modified version of the notorious tumor suppressive microRNA, miR-34a. Coupling these second-generation ligands, that have enhanced circulation kinetics, with a stabilized version of miR-34a will finally allow for transitioning microRNAs successfully into the clinic, in this case for treating the top two most deadliest cancers – lung and prostate cancers.

PI_NAMEs: KASINSKI, ANDREA L (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 2019-nCoV;Affinity;Albumins;Antineoplastic Agents;Antitumor Response;Binding;Biodistribution;cancer cell;cancer therapy;Carcinoma;Cells;Circulation;Clinic;Clinical;Colon Carcinoma;Coupling;Data;delivery vehicle;Diagnostic;Disease;Dose;Drug Kinetics;Drug Targeting;FDA approved;folate-binding protein;FOLH1 gene;Folic Acid;Funding;Gene Targeting;Generations;Goals;Half-Life;Hour;Implant;improved;in vivo;in vivo Model;Kinetics;Lead;Life;Ligands;Liver;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methods;microRNA delivery;MicroRNAs;Mission;Mus;Non-Small-Cell Lung Carcinoma;nuclease;Oncology;overexpression;Phase;prevent;Property;prostate cancer cell;Public Health;Renal Carcinoma;Renal clearance function;risk mitigation;RNA;RNA Interference;RNA vaccine;Safety;safety study;Serum;Serum Albumin;Small RNA;Specificity;success;Testing;Therapeutic Agents;Therapeutic antibodies;therapeutic miRNA;therapeutic RNA;Time;Treatment Protocols;tumor;United States National Institutes of Health;uptake;Work;Xenograft procedure

PROJECT_TITLE: Ligand-mediated, vehicle-free delivery of small RNAs


ADMINISTERING_IC: AT

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Integrative Medicine modalities that may improve health, including meditation, yoga, tai chi, acupuncture, and massage, are widely used by Americans. Evidence for the health effects of these practices, however, has important limitations. This T32 grant will train outstanding pre- and postdoctoral scientists to perform well- designed research on integrative medicine approaches, and the training program will prepare a new generation of researchers to expand our understanding of whether and how integrative medicine approaches work for specific health conditions.

PI_NAMEs: ADLER, SHELLEY R (contact);CHAO, MARIA T

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TITLE: Training Researchers in Clinical Integrative Medicine (TRIM)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Patient Safety

ORG_CITY: San Diego

ORG_NAME: ALUME BIOSCIENCES, INC.

PHR: NARRATIVE There is an unmet need to improve the intraoperative visualization of nerves and ureters to preserve function and minimize patient morbidity following minimally invasive surgeries. Alume Biosciences has developed a novel peptide dye conjugate (ALM-488) that can be delivered intravenously before surgery as an agent to aid visualization of nerves during surgery. In this proposal, Alume proposes to complete a Phase 2 trial in patients undergoing minimally invasive abdominal surgery or tumor resection to establish efficacy of ALM-488 to improve intraoperative nerve and ureter visualization.

PI_NAMEs: BERMAN, BRETT J.;WHITNEY, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: Abdomen;Academic Medical Centers;Accidents;Accounting;afferent nerve;Anatomy;autonomic nerve;Binding;Biological Sciences;Burn injury;California;cancer surgery;chronic pain;Clinical;clinical candidate;clinical translation;Colon Carcinoma;Color;Colorectal Cancer;Colorectal Surgery;commercialization;contrast enhanced;Development;Dissection;Dose;Dose Limiting;Dyes;Endoscopes;Excision;Exhibits;Fluorescence;fluorescence imaging;Functional disorder;gastrointestinal;Goals;Head and neck structure;Head and Neck Surgery;Health;Hiatal Hernia;high risk;Hour;Human;imaging agent;improved;in vivo;Incidence;indexing;Individual;Infection;Injury;instrumentation;Intravenous;Intravenous infusion procedures;Label;Laparoscopes;Laparoscopic Surgical Procedures;Length;Light;Lighting;Location;Malignant neoplasm of ovary;Measurement;Methods;minimally invasive;Monitor;Morbidity - disease rate;Motor;Multicenter Trials;Nerve;nerve agent;nerve damage;nerve injury;nerve supply;novel;Numbness;open label;Operating Rooms;Operative Surgical Procedures;Paralysed;Participant;patient population;Patient-Focused Outcomes;Patients;Pelvis;Peptides;Peripheral Nerves;Pharmaceutical Preparations;Phase;phase 3 testing;Phase I/II Trial;phase II trial;Postoperative Complications;Postoperative Period;preclinical study;preservation;prevent;Procedures;prospective;protein aminoacid sequence;repaired;research clinical testing;Respiratory Diaphragm;Rodent;Safety;Schedule;Sexual Dysfunction;Small Business Innovation Research Grant;Stretching;Structure;Surgeon;System;Texture;Time;Tissues;Toxic effect;Trauma;tumor;Tumor Cell Invasion;Tumor Tissue;Universities;Ureter;urinary;Visual;Visualization

PROJECT_TITLE: Development of ALM-488 for nerve and ureter visualization during abdominal surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The goal of this proposal is to create a National Resource in Glycoscience that will offer service and hands- on training for compositional analysis and detailed structural characterization of all classes of complex carbohydrates, including glycoproteins, polysaccharides, and glycolipids to the greater scientific community. We propose to combine a complimentary array of our existing high-demand services and create a “National Glycoscience Resource”-CCRC Service and Training (GlyCore) that will enable us to continue to offer and enhance our cutting edge services in glycoscience, hands-on training courses and workshops and to make them easily accessible to the biomedical science community. We will continue to offer four well-received and well- established hands-on training courses in glycoscience, and have a robust infrastructure support with well- developed protocols for sample receipt, sample handling, sample tracking, storage, data archiving, and reporting.

PI_NAMEs: AZADI, PARASTOO  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: archive data;Area;Bacterial Polysaccharides;Biochemical;Biological Assay;Carbohydrates;Categories;Cell Differentiation process;cell type;Cells;chemical synthesis;Chemicals;Communities;Complex;Country;data archive;depolymerization;Disaccharides;Educational workshop;experience;Fingerprint;Funding;GAG Gene;Gas Chromatography;genetic linkage analysis;Glycoconjugates;Glycolipids;Glycopeptides;Glycoproteins;glycoproteomics;Glycosaminoglycans;Glycosphingolipids;glycosylation;Goals;Home;Individual;Industry;Infrastructure;instrument;interest;liquid chromatography mass spectrometry;Maps;Mass Spectrum Analysis;meetings;Molecular;molecular modeling;Molecular Weight;Monosaccharides;National Institute of General Medical Sciences;new technology;Nonprofit Organizations;Nuclear Magnetic Resonance;Output;outreach;physical separation;Polysaccharides;Property;Protein-Carbohydrate Interaction;Protocols documentation;Reporting;Research;Research Personnel;Research Training;Resources;Sampling;Science;Scientist;Security;Services;Site;stem;Structure;symposium;Techniques;Technology;Tissues;tool;Training;Training Activity;transcriptome;United States National Institutes of Health;Universities

PROJECT_TITLE: A National Glycoscience Resource - CCRC Service and Training


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: JACKSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative The proposed research aims to identify cell specific diurnal rhythms of molecular clock molecules and neuropeptides in the human hypothalamus and disruption in bipolar disorder as a first step in identifying the neuropathological correlates of circadian dysfunction in subjects with bipolar disorder. These human postmortem studies will provide a foundation of hypothalamic diurnal rhythms in human subjects and key insight into the neuropathology of the hypothalamus in bipolar disorder, a region critically involved in circadian rhythm regulation.

PI_NAMEs: PANTAZOPOULOS, HARRY  (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Address;Anxiety;anxiety symptoms;Area;Autopsy;biological adaptation to stress;Bipolar Disorder;Brain;Brain region;Calcium Channel;Cell Nucleus;cell type;Cells;Cessation of life;circadian;Circadian Dysregulation;Circadian Rhythms;Clock protein;cohort;Corticotropin-Releasing Hormone;Data;depressive symptoms;design;Development;diagnostic development;Disease;Diurnal Rhythm;Dopamine;emotion regulation;Foundations;Functional disorder;Gene Expression;Genes;Genetic;Genetic Polymorphism;genome wide association study;Health;Hour;Human;human subject;Hydrocortisone;Hypothalamic structure;Immunofluorescence Immunologic;Impairment;improved;In Situ Hybridization;insight;Knowledge;L-Type Calcium Channels;Link;Maps;Measures;Mental Depression;Molecular;molecular clock;mood regulation;Moods;neural circuit;Neurons;neuropathology;Neuropeptides;Neurotransmitters;novel therapeutics;Organism;Output;paraventricular nucleus;Pathology;Patients;Pattern;Periodicity;Phase;Population;protein expression;Proxy;Regulation;Research;Risk;Rodent;Role;Sampling;Severities;Signal Transduction;Signaling Molecule;Somatostatin;Somatostatin Receptor;somatostatin receptor 5;SSTR5 gene;Stress;suprachiasmatic nucleus;Testing;Therapeutic;Time;time use;Treatment Efficacy;Variant;virtual

PROJECT_TITLE: Diurnal Molecular Rhythms of the Human Hypothalamus and Involvement in Bipolar Disorder

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Flow Cytometry, Cell Sorting, Imaging, and Mass Cytometry are essential tools for a wide range of methodologies aimed at understanding complex single cell proteomic and genomic cancer research. Dr. Jared K. Burks, the co- Director of the Flow Cytometry and Cellular Imaging Facility – North Campus at MD Anderson Cancer Center, identifies, acquires, and develops cutting-edge single cell technologies in support of the cancer research performed at MD Anderson. Technologies, including Akoya Biosciences Vectra Polaris featuring Phenotics 2.0, Fluidigm Helios Suspension Mass Cytometer and Hyperion Imaging Mass Cytometer (IMC), are being assessed, refined, standardized and expanded for use at MD Anderson and for researchers worldwide.

PI_NAMEs: BURKS, JARED KYLE (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: anti-cancer research;Biological Assay;Biological Sciences;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer genomics;Cell Communication;Cell Separation;Cells;cellular imaging;Collaborations;Complex;Comprehensive Cancer Center;Consultations;Core Facility;Cytometry;Education;Ensure;Equipment;Experimental Designs;Faculty;flexibility;Flow Cytometry;Growth;Hour;Image;imaging facilities;imaging system;Immune;Industry;Institution;instrumentation;liquid crystal polymer;member;Methodology;Microscope;Modeling;neoplastic cell;new technology;novel;Process;programs;Proteomics;Publications;Reporting;Research;Research Personnel;Services;single cell technology;Source;spectrograph;Standardization;stem;success;Suspensions;Technical Expertise;Technology;Testing;Tissues;tool;Training;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Single Cell Spatial Analysis in Tissue


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: OVERALL PROJECT NARRATIVE State-of-the-art technologies afforded by the WU-RDRRC will advance our understanding of the pathogenesis of rheumatic diseases through high impact basic and clinical/translational research endeavors conducted by cross-disciplinary teams of experts. Findings will potentially translate to improvements in treatment options for patients suffering from various rheumatic diseases.

PI_NAMEs: LENSCHOW, DEBORAH J;PHAM, CHRISTINE T. (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Address;Adopted;Area;Autoimmunity;Basic Science;biobank;Biomedical Engineering;Cell Line;Cell Therapy;cellular imaging;Clinical;Clinical Data;Clinical Research;Collaborations;Collection;Complex;Core Facility;cost effective;COVID-19 pandemic;Cytometry;Data;Data Collection;Deposition;design;Discipline;Disease;disease model;Education;Electronic Health Record;Environment;Evidence based program;Extramural Activities;Fostering;Funding;Genome engineering;Goals;Grant;Health;health care disparity;high dimensionality;Image;improved;Inflammation;Infrastructure;innovative technologies;interest;Knock-in;Knockout Mice;Laboratories;Lupus;lupus registry;member;Mentors;Microscopy;model building;Modeling;Molecular Analysis;multidisciplinary;multimodality;new technology;next generation;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Patients;Phenotype;Philosophy;Physicians;Positioning Attribute;Postbaccalaureate;pre-clinical;precision medicine;programs;recruit;Regenerative Medicine;Reporting;repository;Research;Research Personnel;Resources;response;Rheumatism;Rheumatology;Scientist;Services;social;social health determinants;Talents;Technology;Testing;Training;transcriptomics;Translating;Translational Research;Universities;Washington

PROJECT_TITLE: Washington University Rheumatic Diseases Research Resource-based Center


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PI_NAMEs: PHAM, CHRISTINE T. (contact)

PROJECT_TERMS: Advisory Committees;Awareness;career;Clinical Research;Collaborations;Communication;Communities;cost effective;Critical Care;Digestive System Disorders;Discipline;Discipline of obstetrics;Education;England;Extramural Activities;Faculty;Fostering;Funding;Gastroenterology;Goals;Grant;Gynecology;Institution;Interdisciplinary Study;interest;Laboratories;Leadership;Lung;Measures;Medical;Medicine;member;Midwestern United States;Musculoskeletal;Names;Orthopedic Surgery;Output;Pathway interactions;Peer Review;Performance;Physicians;Postbaccalaureate;professor;programs;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Rheumatism;Science;Scientific Evaluation;Scientist;Series;Services;synergism;Talents;Technology;Training;Translational Research;Universities;Washington;Work


ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE – OVERALL The goal of the UPMC HCC Ovarian Cancer SPORE is to improve the outcomes of patients with ovarian cancer. We propose (i) three clinical trials, each with critical translational aims to identify patients most likely to benefit from therapy; and (ii) a Career Enhancement Program (CEP) and Developmental Research Program (DRP) to ensure a pipeline of ovarian cancer researchers as well as novel diagnostic and therapeutic strategies. The three projects, CEP, and DRP will be supported by three cores to increase success.

PI_NAMEs: BUCKANOVICH, RONALD J (contact);EDWARDS, ROBERT PAGE

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Advocate;American;anti-cancer research;Archives;Bioinformatics;Biometry;BRCA1 gene;Bromodomains and extra-terminal domain inhibitor;cancer care;Cancer Center;Cancer Etiology;Cancer Patient;Carboplatin;career;career development;Cell Cycle Checkpoint;Cell Cycle Checkpoint Genes;Cells;Cessation of life;checkpoint therapy;Chemoresistance;chemotherapy;Clinical;Clinical Data;Clinical Trials;Collaborations;Cost Sharing;data resource;design;Development;Diagnosis;Disease;Disease Progression;Disease Resistance;DNA Repair;Doctor of Philosophy;Dose;Ensure;Epigenetic Process;Erinaceidae;Exclusion;experience;Experimental Models;EZH2 gene;Funding;Future;Generations;Goals;homologous recombination;homologous recombination deficiency;Human;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;inhibitor;inhibitor therapy;innovation;Institution;Investments;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;Minority Groups;Mitotic;Modeling;Molecular;mortality;multidisciplinary;multipotent stromal progenitor;Myeloid-derived suppressor cells;New Agents;Newly Diagnosed;notch protein;novel diagnostics;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathology;Patient Care;patient response;Patient-Focused Outcomes;Patients;Pennsylvania;personalized medicine;Phase;Phase Ib Trial;phase II trial;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;potential biomarker;pre-clinical;Prediction of Response to Therapy;prevent;Principal Investigator;Prognosis;Program Research Project Grants;programs;Proteins;recruit;Recurrence;Relapse;Research;Research Infrastructure;Research Personnel;Resistance;Resource Sharing;response;Science;Scientist;Signal Transduction;smoothened signaling pathway;stem cells;stromal progenitor;success;synergism;Technology;Testing;therapeutic development;therapy resistant;Time;tissue resource;TOPBP1 Gene;Translational Research;treatment strategy;tumor;tumor microenvironment;Underrepresented Minority;Woman

PROJECT_TITLE: HCC Ovarian Cancer SPORE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: BUCKANOVICH, RONALD J (contact)

PROJECT_TERMS: Administrator;Advocacy;advocacy organizations;Advocate;Agreement;Biotechnology;Budgets;Cancer Center;career;Clinical Trials Cooperative Group;Clinical Trials Network;Code;Collaborations;Communication;Communities;Community Outreach;Computer software;Data;Development;Doctor of Philosophy;Educational workshop;Ensure;Evaluation;experience;Funding;Future;Goals;Guidelines;Individual;Institution;Intellectual Property;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;material transfer agreement;meetings;Monitor;outreach;patient health information;patient oriented;Patients;Periodicals;Policies;Preparation;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;Qualifying;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Safety;Schedule;Science;Scientist;Services;sharing platform;success;tool;translational goal;translational research program;United States National Institutes of Health;Universities;Update;Work


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome

PI_NAMEs: KIM, ALFRED HYOUNGJU (contact)

PROJECT_TERMS: Acceleration;Address;advanced analytics;Animal Experimentation;Animal Experiments;Archives;biobank;Bioinformatics;Biological;Biometry;cellular imaging;Clinical;Clinical Data;clinical phenotype;clinical practice;Collaborations;Collection;Complex;complex data;Consultations;Cost Savings;Cytometry;Data;Data Collection;data registry;Data Set;data sharing;data submission;Databases;Direct Costs;Education;Ensure;Genome;Genome engineering;Genomics;Goals;Grant;health assessment;health disparity;Human;human disease;human tissue;Image;Immunologic Monitoring;Immunophenotyping;Improve Access;Individual;Informatics;Learning;Logistics;Manuscripts;member;Methodology;Methods;Molecular;Mus;Needs Assessment;next generation sequencing;Online Systems;Participant;Pathogenesis;Phenotype;Play;Policies;pre-clinical;Preclinical Testing;prevent;Process;prospective;Proteomics;Registries;Research;Research Personnel;Resources;response;Rheumatism;Role;sample archive;Sampling;sequencing platform;Services;Surveys;Technology;Testing;Time;transcriptomics;Translational Research;United States National Institutes of Health;Universities;Validation;Washington

PROJECT_TITLE: Biobanking and Phenotyping Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE One in eight women in the US will be diagnosed with breast cancer in their lifetime, with the majority requiring surgery as part of treatment, pointing to the critical importance of proper implementation of the Commission on Cancer’s (CoC) new accreditation surgical standard, breast synoptic operative report (SOR). We will use implementation science (IS) to identify barriers and facilitators to breast SOR implementation, synthesize this information into strategies to facilitate SOR integration and test the strategies’ influence on key outcomes (e.g., SOR feasibility). We anticipate that pairing CoC standards with implementation strategies will improve CoC standards implementation and, in turn, improve patient care processes and outcomes, preventing patients from undergoing substandard cancer operations and treatment, decreasing waste in healthcare system costs, and informing future standard-setting to improve the survival and quality of life for cancer patients.

PI_NAMEs: PARK, KO UN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Accreditation;Address;Adherence;Adopted;Adoption;American;Axilla;behavior change;Breast;Breast Cancer Patient;breast surgery;cancer care;Cancer Center;cancer diagnosis;cancer health disparity;Cancer Patient;cancer surgery;care delivery;care systems;career;career development;Caring;Communities;Comprehensive Cancer Center;Computerized Medical Record;cost;Data;design;Development;Development Plans;Diagnosis;Documentation;Education;effective intervention;effectiveness testing;Electronics;Elements;Engineering;Environment;Evaluation;evidence base;Funding;Future;future implementation;Goals;Guidelines;Health Services Research;Health system;Healthcare Systems;Hospitals;implementation barriers;implementation design;implementation determinants;implementation facilitation;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation tool;improved;improved outcome;individual patient;innovation;insight;Institution;Interview;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mentors;Mentorship;Methods;Modification;Monitor;Multicenter Trials;multidisciplinary;Ohio;operation;Operative Surgical Procedures;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Physicians;pilot test;Play;Police;Policies;prevent;Process;Professional Self Regulation;programs;prospective;Qualitative Evaluations;Quality of Care;Quality of life;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Role;Sampling;scale up;Scientist;Standardization;standardized care;Structure;Surgeon;Surgical Oncology;symposium;Techniques;Testing;theories;therapy design;Training;Training Programs;Universities;uptake;Variant;wasting;Woman;women's diagnosis

PROJECT_TITLE: Implementation of Operative Standards in Cancer Surgery to Improve Patient Outcomes

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: OVERALL: PROJECT NARRATIVE: This type 2 U54 application is derived from the existing, productive Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the O’Neal Comprehensive Cancer Center (OCCC) at UAB, which is committed to the elimination of cancer health disparities in racial/ethnic minority and underserved populations in the ‘Deep South,’ particularly among African Americans. By leveraging the distinct yet complementary strengths and resources of this Partnership, rigorous and collaborative transdisciplinary research that encompasses basic biologic, preclinical, educational, behavioral, social, and community-based programs leads to evidence-based solutions and an understanding of the causes of cancer health disparities.

PI_NAMEs: MANNE, UPENDER ;RIVERS, BRIAN M. (contact);YATES, CLAYTON

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Acceleration;Address;Adherence;African American;African American population;Alabama;anti-cancer research;Applications Grants;Award;Basic Science;Behavioral;Behavioral Research;Bioethics;Bioinformatics;Bioinformatics Shared Resource;Biological;biological research;Biometry;Biotechnology;Cancer Biology;Cancer Burden;cancer care;Cancer Center Planning Grant;Cancer Control;cancer education;Cancer Etiology;cancer genomics;cancer health disparity;Cancer Research Project;cancer risk;career;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer screening;Combined Modality Therapy;Communities;community involvement;Complement;Comprehensive Cancer Center;Deep South;Development;dietary;Education;education research;Educational Curriculum;Enrollment;Ensure;Ethics;ethnic minority;Ethnic Population;Evaluation;evidence base;Extramural Activities;Faculty;Foundations;Funding;Goals;graduate student;Grant;Health Disparities Research;health disparity;Healthcare Systems;healthy lifestyle;Heart;high school;Hospitals;immunomodulatory strategy;improved;Institution;Intervention;laboratory experience;Latinx;Link;lung cancer screening;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical;Medical Students;member;Methods;Minority Groups;minority investigator;minority student;Minority-Serving Institution;Modeling;Morehouse School of Medicine;multidisciplinary;NCI-Designated Cancer Center;next generation;Outcome;outreach;outreach program;overexpression;Patients;Peer Review;personalized medicine;Physical activity;Pilot Projects;Policies;Population Sciences;Postdoctoral Fellow;pre-clinical;pre-clinical research;Productivity;programs;Provider;Public Health Informatics;Publications;Publishing;racial disparity;racial minority;recruit;Research;research and development;research faculty;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Reduction;rural dwellers;Scientist;Secure;social;success;summer research;symposium;System;Testing;theories;Therapeutic Trials;traditional care;Training;Training Programs;tumor-immune system interactions;twelfth grade;undergraduate student;underserved area;Underserved Population;Universities;uptake;Vision

PROJECT_TITLE: 1/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_STATE: PA

PHR: NARRATIVE – PROJECT 1 The development of chemotherapy resistance is one of the deadliest steps in ovarian cancer progression. Carcinoma-associated mesenchymal stem cells (CA-MSCs) are stromal progenitor cells within the ovarian cancer tumor microenvironment which drive chemotherapy resistance. Our goal is to target CA-MSCs to prevent the development of chemotherapy resistance.

PI_NAMEs: EDWARDS, ROBERT PAGE (contact)

PROJECT_TERMS: Adipocytes;Binding;Biopsy;BMP2 gene;BMP4;Cancer Patient;cancer stem cell;cancer therapy;Carboplatin;Carcinoma;Cell Reprogramming;Cell Survival;Cells;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Complex;Data;Deposition;Development;directed differentiation;Dose;Enhancers;Epigenetic Process;Event;Extracellular Matrix;Fibroblasts;Fostering;Future;Generations;Genomics;Goals;Growth Factor;high risk;histone methyltransferase;Histones;Homologous Gene;Immune;improved;improved outcome;inhibitor;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Maximum Tolerated Dose;Mediating;Mediator;Mesenchymal;Mesenchymal Stem Cells;Modeling;mortality;mortality risk;Myofibroblast;Neoplasm Metastasis;neoplastic cell;novel strategies;Ovarian;overexpression;Patients;Pattern;pharmacologic;Phase;Phenotype;Platinum;Play;Prevalence;prevent;primary endpoint;Production;Progression-Free Survivals;Property;protein crosslink;recruit;Recurrence;Recurrent disease;Reporting;response;Role;Safety;Sampling;secondary endpoint;Site;stem;stem cells;stemness;Stromal Cells;Stromal Neoplasm;stromal progenitor;therapy resistant;Time;transcription factor;Transcriptional Regulation;Treatment Efficacy;treatment response;tumor microenvironment;tumor progression;tumorigenic;Work;WT1 gene

PROJECT_TITLE: Project 1: EZH2 Inhibition to Prevent/Overcome Chemoresistance


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: COOPER, MEGAN ANNE (contact)

PROJECT_TERMS: Autoimmune Diseases;Award;career;Cell Line;Cell model;Cells;Clinical Investigator;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;community center;Consultations;cost effective;CRISPR/Cas technology;Data Analyses;Development;Disease;disease model;disease phenotype;Education;Education and Outreach;education resources;Embryo;Engineering;Equipment;experience;Funding;Gene Targeting;Generations;Genetic;Genetic Engineering;Genetic Services;genetic technology;Genetically Engineered Mouse;genetically modified cells;Genome;genome editing;Genome engineering;genome sequencing;genomic data;Genomics;Goals;Grant;Individual;induced pluripotent stem cell;Inflammatory;Infrastructure;innovation;Investigation;Knockout Mice;Laboratories;Leadership;meetings;member;Mission;model organism;Modeling;mouse model;Mus;Mutation;novel;Patients;pre-clinical;Pre-Clinical Model;Production;Publications;Reagent;research and development;Research Personnel;Research Support;Resources;Rheumatism;Services;skills;stem cell model;stem cells;success;targeted treatment;Techniques;Technology;Testing;tool;transcriptome sequencing;Transgenic Organisms;translational genetics;Translational Research;translational scientist;Universities;Washington;Work

PROJECT_TITLE: Genome Engineering Core


NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Whole-body regeneration (the ability to regenerate all body parts) is one of the greatest mysteries in biology. Harnessing this process would provide therapeutic strategies to enable tissue regrowth in human patients after any type of traumatic injury or surgery. The proposed studies will establish the fundamental knowledge that is needed to understand and control the regulatory program(s) of regeneration.

PI_NAMEs: WANG, BO  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Animals;Biological;Biology;Body part;Cell Proliferation;Chimera organism;comparative;Coupled;experimental study;Fresh Water;functional genomics;Genes;Growth;Human;Immunologics;Knowledge;Medical;Natural regeneration;network dysfunction;Operative Surgical Procedures;Pathogenicity;Pathway interactions;Patients;Planarians;Platyhelminths;Process;programs;regenerative;Regenerative Medicine;response;Risk;Schistosoma;single cell ATAC-seq;Systems Biology;Therapeutic;tissue regeneration;Tissues;tool;transcriptomics;Traumatic injury;wound

PROJECT_TITLE: Comparative systems biology defines regulatory mechanisms in whole-body regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


PI_NAMEs: PISTON, DAVID W (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Animals;Area;Basic Science;Biological Assay;Biological Models;biological research;bone;cell behavior;Cell Physiology;cell type;Cells;cellular imaging;Charge;Complement;Consultations;Contrast Media;cost;Cryoelectron Microscopy;Custom;data acquisition;Data Analyses;Data Set;Dedications;Development;Dimensions;Disease;Education;Educational workshop;Electron Microscopy;Electrons;Ensure;Equipment;Experimental Designs;Faculty;Feedback;Fluorescence;Funding;Generations;Goals;Grant;Human Resources;Image;Image Analysis;imaging facilities;imaging study;Imaging Techniques;Imaging technology;improved;Individual;Informatics;innovation;Institution;instrumentation;Investments;Ions;Joints;Laboratories;Laboratory Research;Learning;Light;light microscopy;live cell imaging;Macromolecular Complexes;member;Methodology;Microscope;Microscopic;microscopic imaging;Microscopy;model organism;molecular imaging;novel;operation;Optics;Organ;Pathogenesis;Pathway interactions;Play;Preparation;Process;programs;Proteins;quantitative imaging;Research;Research Personnel;research study;Resolution;Resources;response;Rheumatism;Roentgen Rays;Role;Sampling;Scholarship;Services;single molecule;Specialist;Specimen;Speed;Structure;superresolution imaging;superresolution microscopy;System;Technical Expertise;Techniques;Technology;technology platform;Time;tissue fixing;Tissues;tool;Training;Translating;Translational Research;translational study;two-dimensional;two-photon;Universities;Visualization;Washington;Work;X ray microscopy

PROJECT_TITLE: Cellular Imaging Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: NARRATIVE – PROJECT 2 PARP inhibitors (PARPi) are widely used in ovarian cancer and now are approved in first- and second-line settings, but they are limited by emergence of resistance. We propose to address this unmet need and reverse PARPi resistance by targeting BRD4 with the clinically applicable BET inhibitor (BETi), ZEN3694. We propose that BET-PARP inhibition combination will lead to functional deficiency in homologous recombination and impairment of G2-M cell cycle by suppressing WEE1 expression.

PI_NAMEs: MAHDI, HAIDER  (contact)

PROJECT_TERMS: 19p13;Address;ATAC-seq;biomarker driven;Biopsy;BRCA1 gene;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Patient;Cell Cycle;ChIP-seq;Clinical;clinical application;clinical predictors;Combination Drug Therapy;Data;Disease Resistance;DNA Damage;Dose Limiting;efficacy evaluation;epigenetic therapy;Epithelial ovarian cancer;G2/M Checkpoint Pathway;Gene Expression;Genes;genome-wide;genomic locus;homologous recombination;homologous recombination deficiency;Impairment;improved outcome;inhibitor therapy;innovation;M cell;Malignant neoplasm of ovary;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mitosis;Mitotic;Modeling;Mutation;novel;novel therapeutics;objective response rate;Organoids;overexpression;PARP inhibition;participant enrollment;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase Ib Clinical Trial;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;Precision Run-On Sequencing;predicting response;Prediction of Response to Therapy;predictive marker;Prognosis;Rationalization;Recurrence;Regimen;Resistance;response;response biomarker;restoration;Role;Safety;safety assessment;Sampling;Serous;standard of care;synergism;Testing;therapy development;Time;Tissues;TOPBP1 Gene;Toxic effect;treatment response;tumor;tumor DNA;Up-Regulation

PROJECT_TITLE: Project 2: Combination PARPi-BETi to Overcome PARPi Resistance