ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Skin Cancer

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Efficient DNA excision repair is critical to maintain genome stability and prevent the accumulation of carcinogenic mutations. How excision repair factors are able to recognize and repair DNA lesions resident in damaged nucleosomes, however, is unclear. In this application, we propose to use next-generation sequencing methods to characterize the fate of damaged nucleosomes in cells and elucidate how DNA repair and chromatin modifying factors promote the recognition and repair of DNA lesions in chromatin.

PI_NAMEs: WYRICK, JOHN J (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acetyltransferase;Address;Affect;Award;base;Base Excision Repairs;Base Pairing;cancer predisposition;carcinogenesis;Carcinogenesis Mechanism;carcinogenicity;Cell Line;Cells;Chemoresistance;Chromatin;Chromatin Structure;Complex;cytotoxic;Data;Defect;DNA;DNA Alkylation;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;Enzymes;Eukaryotic Cell;Event;Excision Repair;gene repair;gene repression;Genes;Genetic Transcription;Genome;Genome Stability;genome-wide;High-Throughput Nucleotide Sequencing;Histone Acetylation;histone acetyltransferase;Histone H3;Histone H4;histone methylation;histone modification;Histones;Human;In Vitro;Individual;Inherited;Lesion;Linker DNA;Lysine;Malignant Neoplasms;Maps;Melanoma;Melanoma Cell;Methods;Methylation;methylpurine;Minor;Modeling;Molecular;mutant;Mutate;Mutation;next generation sequencing;novel;Nucleosomes;Nucleotide Excision Repair;Pathway interactions;Patients;Phenotype;Play;Positioning Attribute;prevent;Process;Proteins;Pyrimidine Dimers;Regulation;Relaxation;repaired;response;Role;SAGA;Skin;Skin Cancer;Testing;therapy resistant;Time;Transcription-Coupled Repair;ultraviolet damage;ultraviolet irradiation;UV carcinogenesis;UV induced;UV Mutagenesis;UV Radiation Exposure;Variant;Xeroderma Pigmentosum;yeast genome;Yeasts

PROJECT_TITLE: Regulation of DNA Excision Repair in Chromatin


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The hallmark of systemic lupus erythematosus (SLE) is the production of antibodies to nuclear antigens such as ribonucleoproteins and DNA. The proposed studies focus on the origin and mechanisms of pathogenic anti-DNA responses in SLE, ultimately aiming to develop new approaches towards their therapeutic blockade.

PI_NAMEs: BUYON, JILL P;GEORGIOU, GEORGE GEORGIOU;REIZIS, BORIS  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Abbreviations;Adoptive Transfer;Affinity;Anti-DNA Antibodies;Antibodies;Antibody Formation;Antibody Response;Antigen-Antibody Complex;Antigens;Autoantibodies;Autoimmunity;Automobile Driving;autoreactive T cell;autoreactivity;Award;B-Cell Activation;B-cell receptor repertoire sequencing;B-Lymphocytes;biobank;Blocking Antibodies;cell free DNA;Cell Size;Cells;Chromatin;Circulation;Clinical;Clinical Course of Disease;Clone Cells;cross reactivity;Data;Deoxyribonucleases;Development;Disease;DNA;DNA Packaging;DNA sequencing;ds-DNA;early onset;Epitopes;Experimental Models;Genes;Genets;Helper-Inducer T-Lymphocyte;Human;Immune;immune activation;Immunity;immunogenic;Immunoglobulin G;Immunology;imprint;in vivo;insight;Knockout Mice;Lupus Nephritis;Measures;Mediating;Modeling;Monoclonal Antibodies;Mus;Mutation;Nature;neutralizing antibody;non-genetic;novel;novel strategies;Nuclear Antigens;Nucleosomes;null mutation;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;Phenotype;Plasma;Plasmablast;Polynucleosome;Productivity;Proteomics;Regulation;response;Ribonucleoproteins;Role;seropositive;Severity of illness;Specificity;Supporting Cell;Systemic Lupus Erythematosus;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues

PROJECT_TITLE: Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus Erythematosus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Health Services;Hematology;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Our project to adapt a powerful laboratory test for leukemia diagnosis in Kenya creates three unique interconnected systems critical for the project's success. The three systems, sample collection and handling, advanced high parameter flow cytometry, and comprehensive training of personnel, are routine practice in the United States and other High-Income Countries but are not part of the fabric for routine care structure of most Low- and Middle-Income Countries yet. Demonstrating the feasibility and sustainability of this process has the potential to improve the diagnosis of childhood leukemia vastly and, with available treatments in Kenya, to save lives.

PI_NAMEs: VIK, TERRY A (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acute;Acute Lymphocytic Leukemia;Africa;Africa South of the Sahara;Algorithms;American;Biological Assay;Blood Screening;Blood specimen;Bone Marrow;Bone Marrow Aspiration;Burkitt Lymphoma;cancer care;Caring;Catchment Area;Child;Childhood Leukemia;Classification;Clinical;Collaborations;Color;cost;cost effective;Country;curative treatments;Data;design;Diagnosis;Diagnostic Services;Diagnostic tests;Distant;Dryness;Early Diagnosis;Educational Models;Educational process of instructing;Ensure;Flow Cytometry;Fluorescent Antibody Technique;Funding;genetic testing;Goals;health care availability;Health education;Hematologic Neoplasms;HIV;hospital care;Hospital Referrals;Hospitalization;Hospitals;Human Resources;Immunohistochemistry;Immunophenotyping;improved;Income;Indiana;industry partner;Institution;Kenya;Laboratories;Learning;leukemia;leukemia/lymphoma;Leukemic Cell;low and middle-income countries;Lymphoblastic Lymphoma;Lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;Measures;Medical;medical schools;member;Methods;Minority;Modeling;Monitor;Morphology;Myeloproliferative disease;National Health Insurance;Oncology;patient screening;Patients;Peripheral;peripheral blood;Population;Procedures;Process;Provider;Public Health;Reagent;Research Personnel;routine care;routine practice;sample collection;Sampling;screening;Site;Speed;Structure;success;Symptoms;System;Technology;telehealth;Temperature;tertiary care;Testing;Textiles;tool;Training;Training Programs;Travel;treatment response;Tube;United States;Universities;World Health Organization;young adult

PROJECT_TITLE: Adapting flow cytometry methods for early detection of acute hematologic malignancies in Kenya including the improvement of sample flow processes and technical training of personnel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Lung

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

ORG_STATE: CA

PHR: Acute kidney injury is a common complication in critically ill patients who require mechanical ventilation to support life, with devastating consequences for morbidity and mortality. The causes of acute kidney injury due to mechanical ventilation are unclear, and no proven treatments exist. This project explores the physiological and molecular pathways of ventilator induced kidney injury to identify pathways for novel treatments.

PI_NAMEs: HEPOKOSKI, MARK LAWRENCE (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: absorption;Acute Renal Failure with Renal Papillary Necrosis;Back;Biological Markers;Cell Death;cell injury;Cessation of life;Clinical Research;Complex;Complication;Consumption;Critical Illness;Data;Denervation;Development;Diuretics;Electrolytes;Excretory function;experience;Future;Glomerular Capillary;Glomerular Filtration Rate;glomerular function;Goals;hemodynamics;Histology;Homeostasis;Hypoxia;improved;Inflammatory;inflammatory marker;Injury;Injury to Kidney;Intervention;Kidney;kidney cell;kidney metabolism;kidney vascular structure;Knowledge;Life;Ligation;Liquid substance;Lung;Lung Compliance;lung injury;Mechanical ventilation;Mechanics;Metabolic stress;Metabolism;Micropuncture;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Natriuresis;Nephrology;Nephrons;Nerve;novel;Outcome;Oxygen;Oxygen Consumption;Pathway interactions;Patients;Persons;Physicians;Physiological;Physiology;Population;Pre-Clinical Model;preclinical study;pressure;prevent;Rattus;Renal Blood Flow;Renal function;Renal tubule structure;Renin-Angiotensin System;response;Risk;Risk Factors;Rodent;Role;Scientist;Sodium;solute;standard care;Structure;surfactant;targeted treatment;Techniques;Testing;Tidal Volume;Time;translational study;translational therapeutics;treatment strategy;Tubular formation;United States;Vascular resistance;Ventilator;Work

PROJECT_TITLE: Mechanisms of acute kidney injury due to mechanical ventilation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Description The goal of this research project is to understand the underlying molecular mechanisms of human retinitis pigmentosa, the most common form of inherited retina diseases. Through studying of the Ddx41 mutant mice model just established, we plan to reveal how the DDX gene family is involved in retinal degeneration in human. In parallel, we propose to improve the rate of molecular diagnostic for the disease by identifying novel pathogenic mutations and disease associated genes that will address a major gap of the field and provide the basis for developing new therapy.

PI_NAMEs: CHEN, RUI  (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Address;Affect;Alleles;Animal Model;Apoptosis;Bacteria;Biogenesis;Biological Assay;Candidate Disease Gene;Cells;Code;cohort;Collection;Defect;Disease;disease diagnostic;Elements;Enhancers;exome sequencing;experimental study;Family;Family member;feasibility testing;Foundations;Funding;Gene Expression Regulation;Gene Family;gene replacement therapy;gene therapy;Generations;Genes;Genetic;genome sequencing;Goals;helicase;Homeostasis;Human;human disease;improved;In Vitro;in vivo;Inherited;insight;Investigation;Knockout Mice;Knowledge;Link;member;Messenger RNA;Methods;Molecular;Molecular Diagnosis;molecular diagnostics;mouse model;Multiomic Data;multiple data sources;mutant;mutant mouse model;Mutant Strains Mice;Mutation;mutation screening;Newly Diagnosed;novel;novel therapeutics;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Phenotype;Play;proband;Process;Protocols documentation;Regulatory Element;Research Project Grants;Resources;Retina;Retinal Defect;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;RNA;RNA Helicase;RNA metabolism;RNA Splicing;Role;screening;segregation;Software Tools;Technology;Testing;Therapeutic;Translations;Untranslated RNA;Validation;Variant;Visual System;whole genome;Work

PROJECT_TITLE: Molecular Basis of Human Visual System Disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Infectious Diseases

ORG_CITY: TUSCALOOSA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Our research goals are to understand why older individuals exhibit higher severity of and mortality from viral infections than younger adults and how viruses evolve within their aged hosts. Our studies in the fruit fly Drosophila show that we can effectively model aged host-virus interactions in this genetically tractable organism and we are using this system to identify the cellular and molecular mechanisms that underlie the capability of the aged organism to survive infection and limit pathogen mutations and spread. This research could potentially lead to therapeutic improvements for infected elderly patients as well as to the prevention of the emergence of novel viral strains.

PI_NAMEs: CHTARBANOVA, STANISLAVA  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Affect;Age;age effect;age group;age related;aged;Aging;Animals;Antibiotics;Architecture;Bacteria;Biological Assay;Biological Factors;Biological Process;Buffers;candidate identification;Chronic Disease;Communicable Diseases;Complex;coping;Data;Death Rate;Defense Mechanisms;Disease;Disease Outcome;Drosophila genus;Drosophila melanogaster;Elderly;Environment;Eukaryota;Evolution;Exhibits;experimental group;experimental study;Family;fly;Genes;Genetic;Genetic Transcription;Genome;Goals;Government;Healthcare Systems;high risk;Human;immunopathology;Impairment;improved;in vivo;Incidence;Individual;Infection;innovation;insight;Integration Host Factors;knock-down;Knowledge;Life;life span;Link;Measures;Metabolic;metabolic rate;Metabolism;Methods;Mitochondria;mitochondrial genome;model organism;Modeling;Molecular;molecular modeling;Morbidity - disease rate;mortality;Mutation;Mutation Analysis;next generation sequencing;novel;Nucleotides;older patient;Older Population;Organism;Oxidative Stress;Oxygen Consumption;pathogen;pathogenic virus;Pathogenicity;Pathologic;pharmacologic;Physiological;Planets;Play;Population;Predisposition;Prevention;Prevention strategy;Process;Proteins;Public Health;Research;Resolution;response;RNA;RNA Virus Infections;RNA Viruses;Role;Severities;sex;Speed;Spirometry;survival outcome;System;Testing;Tetracyclines;Therapeutic;trait;transcriptome sequencing;treatment strategy;Variant;Viral;Viral Genome;Viral Load result;Virulence;Virus;Virus Diseases;virus host interaction;Wolbachia;young adult

PROJECT_TITLE: Mechanisms underlying aged host-virus interactions

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: ATLANTA

ORG_DEPT: UROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative: The CD8 T-cell response to cancer controls survival of patients and the response to immunotherapy drugs. This proposal will study the genetics of kidney cancers to understand why some patients have high T cell infiltration and others have low. The overall goal is to develop treatments to overcome these mechanisms to allow better immune responses to kidney cancer.

PI_NAMEs: KISSICK, HAYDN  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affect;Antigen-Presenting Cells;Area;Bladder;Brain;cancer cell;Cancer Control;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Separation;Cells;checkpoint therapy;Clear Cell;cytotoxic;Data;Disease Progression;disorder control;Effector Cell;effector T cell;Energy Metabolism;Energy Metabolism Pathway;Event;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Glycolysis;Goals;Head and Neck Neoplasms;Heterogeneity;Human;Immune;Immune checkpoint inhibitor;Immune response;immunogenic cell death;Immunotherapy;Inflammatory;insight;Kidney Neoplasms;Learning;Malignant Neoplasms;Metabolic Pathway;Methods;monocyte;mouse model;Mutate;Mutation;Neoplasm Metastasis;NF-kappa B;novel;Operative Surgical Procedures;Outcomes Research;Oxidative Phosphorylation;Pathway interactions;Patients;PD-1 blockade;Pharmaceutical Preparations;Primary Neoplasm;Production;progenitor;Prostate;Regulatory T-Lymphocyte;Renal Carcinoma;Reporting;Research;response;Signal Pathway;Signal Transduction;Sorting;stem;stem-like cell;System;T cell differentiation;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;therapy development;transcriptome sequencing;tumor;Tumor Antigens;Tumor Escape;tumor heterogeneity;tumor microenvironment;Work

PROJECT_TITLE: Genetic Mechanisms Controlling Kidney Cancer Immune Escape

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Skin contains diverse cell types that provide a physical barrier, sensors of pain and touch, and surveillance of invading organisms or foreign bodies. For this project we aim to construct a near-complete and functioning representation of human skin inside a silicone device, called a tissue chip or organoid-on-a-chip. Our findings will provide new insights into how human skin develops and will produce a new model that researchers and drug developers can use to study a wide range of inflammatory diseases and cancers.

PI_NAMEs: KOEHLER, KARL RUSSELL (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adopted;afferent nerve;Afferent Neurons;appendage;Bacterial Infections;Biological;Biomedical Engineering;Blood Vessels;Calcium;cancer initiation;Cartilage;cell assembly;Cell Communication;Cell Lineage;Cell Therapy;cell type;Cells;Chemicals;Collagen;Cutaneous;Cyst;Data;Dermal;Dermis;design;Detection;Development;Devices;Dextrans;Disease;Ectoderm;Endothelial Cells;Engineering;Epidermis;experimental study;face skin;Fatty acid glycerol esters;fetal;Fetus;Fibroblasts;Foreign Bodies;Freedom;Geometry;Goals;Growing Follicle;Hair;Hair follicle structure;Health;histological specimens;Human;Image;Image Analysis;Immune;Immune system;Immunocompetent;Immunologic Surveillance;Immunology;immunoreaction;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;insight;Invaded;invention;keratinization;keratinocyte;Laboratories;Lasers;Learning;live cell imaging;Longevity;Lymphoid;Maintenance;Malignant Neoplasms;manufacturing process;materials science;matrigel;Measures;mechanical properties;melanocyte;Mesenchymal;Metabolic;Methodology;Microfluidic Microchips;Modeling;Molds;Monitor;Myelogenous;Myeloid Progenitor Cells;Nerve;nerve supply;neural;Neural Crest Cell;neural network;neuroimaging;Neurosciences;neurovascular;next generation;novel;Organism;Organoids;Pain;Perfusion;Pharmaceutical Preparations;Population;Positioning Attribute;Process;Production;quantitative imaging;Radial;Reaction;Research;Research Personnel;Schwann Cells;self assembly;self organization;sensor;Sensory;Silicones;Site;Skin;skin disorder;skin organogenesis;Solid;Specimen;Standardization;stem cells;Stereotyping;Structure;Study models;success;Sweat Glands;System;Technology;Testing;Thick;three dimensional cell culture;Time;Tissue Microarray;Tissues;tool;Touch sensation;transcriptomics;Tubular formation;Vascular Permeabilities;Vascular System;Vascularization;Work;wound;wound healing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Diagnostic errors lead to an estimated 40,000-80,000 deaths every year in the United States. Most diagnostic errors include cognitive causes, but accurate awareness of these causes by the clinicians making them is vital to help them prevent future diagnostic errors. We developed and will now test a resource aimed at helping clinicians gain insight into their own diagnostic performance, a vital step in improving the accuracy and timeliness of diagnosis for patients. .

PI_NAMEs: BRADFORD, ANDREA  (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Evaluation of Calibrate Dx: A Resource to Improve Diagnostic Decisions in the Hospital Setting

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative We have previously demonstrated through high-throughput drug screening that amongst solid tumors, MYCN- amplified neuroblastoma are the most sensitive to targeting of the anti-apoptotic proteins, BCL-2 and BCL-xL, and that targeting BCL-2 with the FDA-approved BCL-2 inhibitor, venetoclax, may be an important strategy in rational drug combination therapies. In this grant renewal, we reveal two clinically-relevant rational drug partners with venetoclax, SHP2 allosteric inhibitors, which have entered clinical trials at a blistering pace, and ABBV-155, a first in-class, in-human antibody drug conjugate BCL-xL inhibitor; in both cases, SHP2 inhibitor + venetoclax, and ABBV-155 + venetoclax, complimentarily modulate BCL-2 family proteins and induce toxicity and marked tumor responses in MYCN-amplified neuroblastoma. Overall, this grant aims to methodically test these two novel combination therapies to gather the preclinical evidence of an effective treatment regimen to put forward in a pediatric cancer with a high unmet need.

PI_NAMEs: FABER, ANTHONY CHARLES (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adult;Age;Antibody-drug conjugates;Antigens;Apoptosis;Apoptotic;Applications Grants;BCL-2 Protein;BCL1 Oncogene;BCL2L1 gene;BCL2L11 gene;Blood Platelets;Bulla;cancer care;cancer cell;Cancer cell line;Caring;CD276 gene;Cells;Cessation of life;Childhood;childhood cancer mortality;Clinic;Clinical;Clinical Data;clinical investigation;clinical translation;Clinical Trials;clinically relevant;Combination Drug Therapy;Combined Modality Therapy;dalton;Dangerousness;Data;Dose Limiting;effective therapy;efficacy evaluation;efficacy study;Event;experimental study;Family member;FDA approved;Funding;Genomics;Goals;Grant;Hematologic Neoplasms;Hematology;high risk;high throughput screening;high-throughput drug screening;Human;In Vitro;Induction of Apoptosis;inhibitor;Malignant Childhood Neoplasm;Malignant Neoplasms;MAP Kinase Gene;MCL1 gene;MEKs;mimetics;Modeling;Molecular;mouse model;MYCN gene;Neuroblastoma;neuroblastoma cell;novel;novel drug class;older patient;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Population;pre-clinical;preclinical study;Protein Family;Protein Tyrosine Phosphatase;Proteins;PTPN11 gene;Ras/Raf;Refractory;Relapse;Reporting;Research Design;Resistance;response;response biomarker;Role;Safety;Series;Solid Neoplasm;Study models;Testing;Therapeutic;Thrombocytopenia;Toxic effect;transcription factor;translational medicine;Translational Research;Translations;Treatment Protocols;tumor;Tumor Subtype;Work

PROJECT_TITLE: ABT-199 based therapies to treat neuroblastoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Pediatric;Primary Immunodeficiencies;Rare Diseases;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative: In this grant renewal, we investigate how the small adaptor protein Crk and its phosphorylation function as a molecular switch to turn immune cell function on and off. We use newly identified pCrk inhibitors as a tool to dissect out Crk’s ability to integrate activating and inhibitory immune cell influences in a variety of clinically relevant settings: live human immune cells, a common human immunodeficiency (partial DiGeorge syndrome, pDGS), and mouse models of breast cancer. Outcomes will result in a new view of Crk in immune responses, tumor suppression, and immune cell exhaustion, and will set the stage for immune restoration in immunodeficiency and cancer.

PI_NAMEs: LIU, DONGFANG  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 22q11;Actins;Activated Lymphocyte;Adaptor Signaling Protein;Adhesions;Affect;Agonist;Antibodies;arm;Biological Assay;Breast Cancer Model;cancer immunotherapy;cancer therapy;Cell Death;cell killing;Cell Physiology;Cells;cellular imaging;clinical application;clinically relevant;conditional knockout;congenital immunodeficiency;CRKL gene;Cytoplasmic Granules;Cytoskeletal Modeling;Cytoskeleton;cytotoxic;cytotoxicity;Data;DiGeorge Syndrome;Disease;exhaust;exhaustion;Exhibits;experimental study;F-Actin;Flow Cytometry;Funding;Genetic;Goals;Grant;Human;Image;imaging system;Immune;immune function;Immune response;immunodeficiency;Immunodeficiency and Cancer;immunological synapse;Impairment;inhibitor;Inhibitory Synapse;Integrins;Knockout Mice;Legal patent;Lipid Bilayers;Lymphocyte Function-Associated Antigen-1;Lytic;Malignant Neoplasms;Mediating;Microscopy;Molecular;Molecular Conformation;Monoclonal Antibodies;mouse model;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;NK Cell Activation;novel;Outcome;Patients;Phosphorylation;Play;programs;Protein Dephosphorylation;Protein Family;proto-oncogene protein c-crk;receptor;Regulation;Resolution;restoration;Role;Shapes;Signal Pathway;Signal Transduction;single-molecule FRET;Small Interfering RNA;small molecule;small molecule inhibitor;Solid Neoplasm;superresolution microscopy;Syndrome;synergism;System;T-Lymphocyte;Techniques;Testing;tool;transcriptome sequencing;Transfection;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Suppression;Western Blotting;Work

PROJECT_TITLE: The adaptor protein Crk in immune responses

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this proposal is to elucidate the role of GATA3 in facial development and to understand why loss of Gata3 results in asymmetric dysmorphic features. Using a combination of existing mouse genetic tools, we will investigate the timing of neural crest cell defects, molecular changes associated with sidedness and the roles of BMP4 and FGF8 in the Gata3 mutant phenotype. Elucidating the basis of facial defects in Gata3 mutants is crucial for future assessment and treatment of individuals with hemifacial microsomia, and therefore this research proposal addresses an important human health problem aligned with the mission of the NIH.

PI_NAMEs: CLOUTHIER, DAVID E. (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Affect;Architecture;Bilateral;BMP4;Branchial arch structure;Cell Death;cell motility;Cells;Cephalic;Chromatin;Cleft Palate;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial structure;craniofacial tissue;cranium;Cues;Data;Defect;design;Development;Ear;Ectoderm;Elements;Embryo;Ensure;Face;Facial asymmetry;FGF2 gene;FGF8 gene;Fibroblast Growth Factor;Future;GATA3 gene;Gene Expression;Gene Expression Profiling;gene regulatory network;Genes;genome wide association study;Goals;Health;Hour;Human;improved;in vivo;Incidence;Individual;Jaw;Limes;Live Birth;malformation;Mandible;Maxilla;Mesenchyme;middle ear;migration;Mission;Molecular;Morphogenesis;Morphology;mouse genetics;Mus;Mutagenesis;mutant;Mutant Strains Mice;Nerve Tissue;Neural Crest Cell;Ocular orbit;Organ;overexpression;Patients;Pattern;Phenotype;Population;Proliferating;Quality of Care;Randomized;Regulatory Element;Repression;Research Proposals;Resolution;Role;Side;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;soft tissue;Specific qualifier value;Structure;Syndrome;Time;Tissues;tool;transcription factor;Treatment Protocols;United States National Institutes of Health;Visceral;Zygomatic bone

PROJECT_TITLE: The role of GATA3 in hemifacial microsomia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Different mutations in the same gene usually give rise to phenotypes that may be more or less severe, but in the case of the RNA-binding protein PUMILIO1 (PUM1), two different missense mutations produce markedly different phenotypes: one is a mild late-onset ataxia, the other is a congenital neurodevelopmental syndrome with global developmental delay and seizures. We hypothesized that the milder disease results from target dysregulation while the more severe disease involves disruption of PUM1 native interactions, and this seems to be the case in cell lines. Now, armed with a robust targetome and interactome for PUM1, we will test this hypothesis thoroughly in mouse models of the mild and severe diseases to uncover their molecular pathogenesis.

PI_NAMEs: GENNARINO, VINCENZO ALESSANDRO (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;anaphase-promoting complex;Anxiety;Ataxia;Attention deficit hyperactivity disorder;Award;Behavior;Behavioral;Binding;Birth;Brain;Brain region;Cell Line;cell type;Cells;Cerebellar Ataxia;Cerebellum;crosslink;crosslinking and immunoprecipitation sequencing;Data;Deletion Mutation;design;Developmental Delay Disorders;Disease;dosage;Exhibits;experimental study;Fatigue;Fibroblasts;FMR1 gene;FRAP1 gene;Functional disorder;Genes;Germ Cells;global developmental delay;Grant;Hand;heart defect;Heterozygote;Hippocampus;Human;Hyperactivity;Immunoprecipitation;Impaired cognition;In Vitro;in vivo;Individual;Knock-in Mouse;Knockout Mice;Learning;loss of function;lymphoblast;Maps;Mass Spectrum Analysis;Mental Depression;Messenger RNA;Missense Mutation;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Molecular Profiling;motility disorder;mouse model;Mus;Mutation;Nervous System Disorder;Nervous System Physiology;neuropathology;neuropsychiatric disorder;Obsessive-Compulsive Disorder;Online Mendelian Inheritance In Man;Ophthalmoplegia;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;postnatal development;Production;Proteins;Proteomics;Psychoses;recruit;Regulation;Repression;RNA-Binding Proteins;Role;Seizures;Sensorineural Hearing Loss;Severities;sex;Spinocerebellar Ataxias;Symptoms;Syndrome;Testing;Time;Transcription Repressor;transcriptome sequencing;transcriptomics;ubiquitin ligase;Untranslated RNA;Variant;Waxes;Work

PROJECT_TITLE: Deciphering the Role of the Pumilio1 in Two Distinct Neurological Diseases

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance The analysis of longitudinal imaging data holds the promise of more accurate computer-aided diagnosis of neurodegenerative disease as well as more effective and efficient quantification of the effects of potential therapeutic interventions. The successful completion of the proposed project would update the mostly widely used longitudinal neuroimaging analysis tools to be significantly more sensitive and specific to Alzheimer’s Disease effects, run orders of magnitude faster and apply to a dramatically wider range of scan types than the tools we developed in the previous cycle, providing them to the thousands of clinicians and researchers that currently use FreeSurfer, improving the power of a wide array of NIH-funded studies to quantify disease and drug effects.

PI_NAMEs: FISCHL, BRUCE  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Accounting;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Anatomic Models;Anatomy;Atrophic;Biological Process;Brain;Brain Edema;Brain imaging;Classification;Clinical;clinical application;Clinical Research;Clinical Trials;Communities;Computer-Assisted Diagnosis;computerized tools;Data;Data Set;deep learning;design;Detection;Diagnosis;Disease;Disease Progression;disorder subtype;Documentation;effective therapy;experimental study;Exposure to;Funding;Hemorrhage;Human;Image;image processing;improved;Individual;insight;interest;Internships;Intervention;Label;Learning;Lesion;longitudinal analysis;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Manuals;Minority Groups;Modeling;Modernization;Monitor;Motion;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;neuron loss;Noise;online tutorial;open source;Patients;Pharmaceutical Preparations;pharmacologic;Population;preservation;Procedures;Process;Randomized;Rare Diseases;Research Personnel;Resolution;Running;Scanning;segmentation algorithm;Sensitivity and Specificity;serial imaging;side effect;Speed;Stream;Surrogate Endpoint;Surrogate Markers;System;Techniques;Technology;Testing;Therapeutic Intervention;Time;tool;Training;training data;Translating;Treatment Efficacy;Underrepresented Minority;United States National Institutes of Health;Update;usability;Validation;Variant;Visualization;Work

PROJECT_TITLE: A Longitudinal Analysis Stream for FreeSurfer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

PHR: Project Narrative The vast majority of patients with TNBCs are offered adjuvant chemotherapy after surgery. However, there are no tools, apart from tumor infiltrating lymphocytes, to optimize therapy for these patients. This proposal will develop a novel multi-modal CaPRI score that integrates clinicopathologic, radiomic, pathomic and immune features in to a single score for predicting risk of lethality and therapeutic optimization.

PI_NAMEs: BADVE, SUNIL S. (contact);GHOSE, SOUMYA

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Adjuvant Chemotherapy;Age;aggressive breast cancer;Antibody-drug conjugates;Artificial Intelligence;Bayesian Modeling;Bayesian Network;Bioinformatics;Biopsy;Black Box;Breast Cancer Patient;cancer imaging;cancer subtypes;Caring;case control;Cells;chemotherapy;Classification;Clinical;Clinical Data;Clinical Trials;cohort;Cox Proportional Hazards Models;Data;data integration;data modeling;deep learning;deep learning model;Development;Diagnosis;digital;digital models;Disease;Disease-Free Survival;diverse data;Event;evidence base;Generations;generative adversarial network;Grant;high risk;Image;Immune;immune imaging;Immunotherapy;improved;Incidence;innovation;Intuition;Malignant Breast Neoplasm;Mammography;Measures;Modeling;mortality risk;multi-ethnic;multimodal data;multimodality;multiplexed imaging;Neoadjuvant Therapy;Neoplasm Metastasis;novel;Oncology;Operative Surgical Procedures;Outcome;Pathology;Patient Care;patient stratification;Patients;Phenotype;Population;Positioning Attribute;predictive marker;predictive tools;Probability;prognostic method;prognostic tool;Proteins;Race;radiological imaging;Radiology Specialty;radiomics;random forest;randomized, clinical trials;Recurrence;Regimen;Research;Residual Cancers;Residual Neoplasm;Risk;Risk Assessment;risk prediction;Role;Sampling;Southwest Oncology Group;spatial relationship;Subgroup;survival outcome;Therapeutic;tool;Toxic effect;Training;translational approach;treatment optimization;triple-negative invasive breast carcinoma;tumor;Tumor-Infiltrating Lymphocytes;Universities;Validation;Visual;Woman

PROJECT_TITLE: Early prediction of lethal phenotypes in triple negative breast cancer using multiscale, multi-modality platforms

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Patient Safety;Precision Medicine;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Predictors of postoperative complications, treatment toxicities, and clinical or patient-reported outcomes in older colorectal cancer patients are not yet completely understood; current clinical management of these patients is largely driven by chronological age, though functional status may be a better predictor of outcomes. We will evaluate clinical and patient-reported outcomes in a prospectively enrolled cohort of newly diagnosed stage I-III colorectal cancer patients ages 70 years and older in relation to physical function, multidimensional geriatric assessment, and relevant biomarkers. Information gained from this project will inform tailored treatments for older colorectal cancer patients based on their physical function, frailty, and biological age, independent of their chronological age.

PI_NAMEs: HARDIKAR, SHEETAL  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;adverse outcome;Age;age related biomarkers;Age Years;aging biomarker;aging related;Albumins;Assessment tool;biological age;Biological Aging;Biological Assay;Biological Markers;Blood;cancer care;cancer diagnosis;Cancer Patient;cancer surgery;Cancer Survivor;Cessation of life;Chronology;Clinical;clinical care;clinical decision-making;Clinical Management;clinical predictors;Cognition;Cognitive;cognitive ability;cognitive function;cohort;colon cancer patients;Colon Carcinoma;Colorectal Cancer;comorbidity;cost effective;Diagnosis;Dimensions;DNA copy number;Elasticity;Elderly;Emotional;Enrollment;Equilibrium;experience;frailty;functional decline;Functional impairment;functional status;Gait;Geriatric Assessment;Goals;Guidelines;hazard;Health;health related quality of life;Health Status;Healthcare;high risk;IL8 gene;improved;individualized medicine;Inflammation;Infrastructure;interest;Interleukin-6;Length;Leukocytes;Linear Regressions;Logistic Regressions;Malignant Neoplasms;Measures;Methods;Mitochondrial DNA;Modeling;Morbidity - disease rate;mortality;Newly Diagnosed;Nutritional;Nutritional status;older adult;Oncology;Operative Surgical Procedures;Outcome;outcome prediction;Patient Outcomes Assessments;Patient Self-Report;patient subsets;Patients;Physical Function;Physical Performance;Population;Postoperative Complications;prospective;Prospective cohort;Proteins;psychologic;public health priorities;Quality of life;recruit;Rectal Cancer;Recurrence;Research Design;response;Risk;risk stratification;Role;Site;social;Surgical complication;survivorship;telomere;Testing;TNF gene;tool;Toxic effect;Treatment outcome;Treatment Protocols;treatment risk;Treatment-related toxicity;United States National Institutes of Health;Variant

PROJECT_TITLE: Geriatric assessment domains in relation to treatment outcomes among older adults with colorectal cancer

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This proposal aims to establish an in vitro human Parkinson's disease (PD) model equipped with a functional cerebral vasculature that mediates the interaction between the neuronal network and peripheral blood. Using this platform, we will investigate PD pathology caused by the pathologic aggregation of α-syn in midbrain dopaminergic neurons and blood. The proposed model is also expected to provide a cost-effective and convenient means to quickly screen candidate treatment options, opening a new avenue for advanced PD research and therapy development.

PI_NAMEs: KIM, DEOK-HO  (contact);LEE, GABSANG

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agonist;alpha synuclein;Anatomy;Animal Model;Anti-Inflammatory Agents;Architecture;assay development;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;Biological Models;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood Vessels;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;Caring;cell type;Cells;Cerebral endothelium;Cerebrovascular system;Characteristics;Circulation;Clinical;clinically relevant;Complex;cost effective;Data;Dementia;design;Development;Devices;Disease;Disease Management;disease model;Disease Progression;Dopamine;dopaminergic neuron;drug candidate;Drug Delivery Systems;drug efficacy;efficacy evaluation;Engineering;Ensure;exenatide;Experimental Models;Ferritin;Functional disorder;GLP-I receptor;Human;Human body;human disease;Human Engineering;human induced pluripotent stem cells;In Vitro;in vivo;induced pluripotent stem cell technology;Iron;Lewy Bodies;Light;Lighting;Mediating;Methods;Microfluidic Microchips;Microfluidics;microphysiology system;Midbrain structure;Modeling;motor control;Movement Disorders;Mus;nanocage;nanomedicine;neural;Neurodegenerative Disorders;neuroinflammation;Neurology;neuron loss;Neurons;neuroprotection;neurovascular;neurovascular unit;novel;optogenetics;Parkinson Disease;Parkinsonian Disorders;pars compacta;Pathogenicity;Pathologic;Pathology;Patients;Perfusion;peripheral blood;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Phosphorylation;Physiology;pre-formed fibril;prevent;Prior Therapy;protein aggregation;Proteins;Reporting;Research;research and development;research clinical testing;screening;shear stress;Site;spatiotemporal;standard of care;stem cell biology;Structure;Substantia nigra structure;symptom management;Symptoms;Syndrome;System;Therapeutic;therapy development;Tissue Engineering;Tissues;Toxin;Treatment Efficacy;Tyrosine;United States

PROJECT_TITLE: High-throughput neurovascular-unit-on-a-chip with OASIS for modeling Parkinson's disease

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biotechnology;Brain Disorders;Eating Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Eating disorders and non-eating disorders internalizing-spectrum disorders (e.g., major depressive disorder, generalized anxiety disorder, social phobia, obsessive-compulsive disorder, posttraumatic stress disorder) are chronic, debilitating, and frequently co-occurring disorders, which often onset in adolescence. This multi-site, multidisciplinary study will identify symptom trajectories across the overall internalising spectrum (across eating disorders and non-eating-disorders-internalising disorders) from late childhood through emerging adulthood in two population-based samples (ABCD and ALSPAC) and identify genetic and phenotypic factors associated with these developmental trajectories. The results will inform nosology, pathophysiology, and ultimately early identification.

PI_NAMEs: MICALI, NADIA ;SZATKIEWICZ, JIN PENG (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Age;Anorexia Nervosa;Anthropometry;Anxiety Disorders;Binge eating disorder;Biological;Birth;Brain;Bulimia;Child;Childhood;Chronic;Classification;Cognition Disorders;cognitive development;cohort;comorbidity;Computing Methodologies;cost;Crystallization;Data;Detection;Development;Developmental Course;Diagnosis;Dimensions;Disease;disease classification;disorder risk;dual diagnosis;Early identification;Early Intervention;Eating;Eating Disorders;effective therapy;emerging adult;emerging adulthood;Equation;Ethnic Origin;Factor Analysis;Functional disorder;Funding Opportunities;Gender;Generalized Anxiety Disorder;Generations;Genetic;Genetic Diseases;Genetic Risk;genome wide association study;Genomic approach;genomic data;Genomics;girls;high risk;high risk population;improved;Joints;Life;Longitudinal cohort;Longitudinal Studies;Machine Learning;Major Depressive Disorder;Measurement;Mental disorders;Metabolic;Methods;Modeling;Moods;multidisciplinary;National Institute of Mental Health;Nationalities;novel;Obsessive-Compulsive Disorder;Onset of illness;Outcome;Parents;Pathway interactions;Pattern;Phenotype;phenotypic data;polygenic risk score;population based;post-COVID-19;Post-Traumatic Stress Disorders;predictive modeling;Prevalence;Prevention;Prevention strategy;Public Health;Race;racial difference;Research;Risk;risk prediction;risk prediction model;Sampling;sex;sex assigned;Site;Social Phobia;societal costs;Statistical Methods;statistics;Structure;Subgroup;symptom cluster;Symptoms;Taxonomy;Techniques;Testing;trait;Work;Youth

PROJECT_TITLE: Integrating developmental and genomic approaches to identify early trajectories of eating and internalizing disorder symptoms

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: Bacterial pneumonia is a leading cause of death in the US and worldwide. Furthermore bacterial pneumonia is one of the most common causes of ARDS, a lung disease also associated with high morbidity and mortality, and bacterial co-infection is known to significantly increase mortality in patients infected with influenza. This project will investigate how one of our own molecules called glypican protects against Staphylococcus aureus pneumonia by promoting the early clearance of bacteria and preventing bacterial invasion of host cells in the lung. The proposed studies will generate new scientific information and identify new therapeutic targets for bacterial pneumonia.

PI_NAMEs: PARK, PYONG WOO  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Abscess;Acute Respiratory Distress Syndrome;Adhesives;Alveolar;Antibiotics;Attention;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;Binding Proteins;Body System;Cause of Death;Cell surface;cell type;Cells;chemokine;co-infection;Controlled Environment;cytokine;Data;Death Rate;Defense Mechanisms;design;Developed Countries;Economic Burden;Environment;Epidemic;Epithelial Cells;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fibronectins;Glypican;Goals;GPC3 gene;Gram-Negative Bacteria;Growth Factor;Heparan Sulfate Proteoglycan;Heparin Binding;heparin receptor;Heparitin Sulfate;Host Defense;human pathogen;Immobilization;Immune Evasion;In Vitro;Individual;Infection;influenza infection;Integrins;Invaded;Knockout Mice;loss of function;Lung;Lung Diseases;Lung infections;Mammals;Mediating;member;Messenger RNA;methicillin resistant Staphylococcus aureus;Microbe;Molecular;Morbidity - disease rate;morphogens;mortality;mouse model;neutrophil;Neutrophil Infiltration;new therapeutic target;Normal Range;pathogen;Pathogenesis;Pathogenicity;Patients;Phenotype;Pneumonia;prevent;Pseudomonas aeruginosa;Quantitative Reverse Transcriptase PCR;receptor;Receptor Signaling;Resistance;RPL29 gene;Site;Staphylococcus aureus;Staphylococcus aureus infection;Streptococcus pneumoniae;syndecan;System;Testing;Tissues;virtual;Virulence

PROJECT_TITLE: Glypicans in Bacterial Lung Infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Projective Narrative Oral squamous cell carcinoma is the sixth most common, infiltrative, and lethal tumor type affecting the adult population. These tumors contain highly migratory and invasive cells, making recurrence rates exceedingly high. This proposal will improve our understanding of how the stiffness of the surrounding environment enables tumor cells to acquire, consolidate, and recall metastatic behaviors that promote invasion of adjacent tissues, which could suggest new therapeutic strategies.

PI_NAMEs: ENGLER, ADAM J (contact);LAMERS, MARCELO LAZZARON

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Acetylation;Address;Adhesions;Adopted;Adult;advanced disease;Affect;Aggressive behavior;ATAC-seq;Behavior;Biological Assay;Breast;Carcinogens;Carcinoma;Cell Adhesion;Cell Culture Techniques;Cells;Cetuximab;ChIP-seq;Chromatin;Clinical;clinically relevant;Coculture Techniques;Collagen;crosslink;Data;Deacetylase;Disease;Ensure;Environment;Epigenetic Process;epigenomics;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Excision;Exhibits;Extracellular Matrix;FDA approved;Gene Expression;Genome;Histology;Histone Acetylation;Histone Deacetylase;histone methylation;histone modification;Histones;Human;human model;improved;In Vitro;in vivo;inhibitor;Invaded;learned behavior;Learning;Lesion;Lip structure;Lysine;Maintenance;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant neoplasm of pharynx;Malignant Neoplasms;mammary epithelium;Manuals;Maps;Mechanics;Mediating;member;Memory;memory acquisition;memory consolidation;men;Mesenchymal;Methylation;Methyltransferase;migration;Moon;Morbidity - disease rate;mortality;mouse model;mouth squamous cell carcinoma;Mus;Necrotic Lesion;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;Operative Surgical Procedures;Oral cavity;oral cavity epithelium;oral tissue;Palpation;Pathway interactions;patient prognosis;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Phosphorylation;Play;Population;preconditioning;Premalignant Cell;Prognosis;Property;Proto-Oncogene Proteins c-akt;PTK2 gene;Quality of life;Recovery;Recurrence;Recurrent tumor;Role;Sampling;Signal Pathway;Signal Transduction;soft tissue;Solid;Sorting;Stains;Survival Rate;Testing;therapeutic target;Time;Tissues;Tongue;tool;transcriptome;tumor;Tumor Cell Invasion;tumor progression;Validation;virtual;Woman

PROJECT_TITLE: Material Stiffness Directs Oral Cancer Migration

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Pineoblastoma (PB) is a poorly understood malignant embryonal tumor of the pineal gland for which safer and more effective therapies are urgently needed. Applying multi-omic analyses to a large international cohort of bulk PB tumor specimens, we recently identified four distinct molecular subgroups of PB, each characterized by discriminatory genetics, demographics, and clinical outcomes. This multidisciplinary proposal seeks to deconstruct the cellular and developmental basis of novel PB subgroups, while producing biologically faithful preclinical models required to improve treatments and outcomes for affected children in the future.

PI_NAMEs: NORTHCOTT, PAUL  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Adolescent;advanced disease;Affect;Atlases;Automobile Driving;Bioinformatics;Biological;biological heterogeneity;Biology;Cell Nucleus;Cells;Central Nervous System;Central Nervous System Neoplasms;Child;Childhood;Childhood Central Nervous System Neoplasm;Childhood Malignant Brain Tumor;Classification;Clinical;clinical diagnosis;clinical heterogeneity;Clinical Research;clinically relevant;cohort;Consensus;Credentialing;curative treatments;Data Set;Death Rate;demographics;Dependence;Development;developmental neurobiology;Diagnosis;Disease;disease model;Early Diagnosis;early phase clinical trial;effective therapy;Engineering;epigenetic profiling;Evaluation;Exhibits;Fostering;Future;Gene Expression Profiling;Generations;Genes;Genetic;genetic profiling;Genetic Transcription;Genetically Engineered Mouse;genome-wide;genomic data;gland development;Heterogeneity;Human;improved;in vivo;Individual;infancy;Infant;innovation;insight;interdisciplinary approach;Interdisciplinary Study;International;Investigation;Knowledge;Life;loss of function;loss of function mutation;Malignant - descriptor;Malignant Neoplasms;malignant state;Maps;MicroRNAs;Modeling;Molecular;Molecular Profiling;mouse model;multidisciplinary;multiple omics;Mus;neuro-oncology;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;older patient;Oncogenic;Outcome;Outcomes Research;overexpression;Pathogenesis;Pathogenicity;Pathologic;Patients;Phenotype;Pineal gland;Pineal Gland Neoplasm;pineoblastoma;pre-clinical;Pre-Clinical Model;preclinical evaluation;preclinical study;progenitor;programs;Quality of life;RB1 gene;Reagent;Recording of previous events;Reporting;Research;Resources;Sampling;Series;single cell genomics;Solid;Specimen;Subgroup;Survivors;Testing;Therapeutic;therapeutic candidate;therapeutic target;transcriptome;treatment and outcome;treatment strategy;tumor;Tumor Biology;tumor heterogeneity;Tumor Promotion;Update;Validation;World Health Organization

PROJECT_TITLE: Deconstructing pineoblastoma origins to advance disease biology, modeling, and therapy

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Nutrition;Prevention;Rare Diseases;Stomach Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Gastric cancer remains an important health burden in the United States and worldwide; its etiology is not fully understood and effective biomarkers for risk assessment are still lacking. Recent advancement in metabolomics techniques provides new opportunities for uncovering new etiologic factors and novel biomarkers to assist in identification of high-risk populations for gastric cancer, and ultimately improve disease prevention. To achieve these goals, we propose to conduct a comprehensive metabolomics study of gastric cancer risk with a multi- center, nested case-control design within a new international consortium.

PI_NAMEs: SHU, XIANG  (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Accounting;Antibodies;Antigens;Asian;Assessment tool;Biological;Biological Markers;biomarker validation;Blood;Body mass index;Cancer and Nutrition;cancer biomarkers;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer risk;candidate marker;carcinogenesis;case control;Cessation of life;Chimeric Proteins;Coffee;cohort;Cohort Studies;Cytotoxin;Data;demographics;design;design verification;Development;Diagnosis;Diagnostic;Dietary intake;disorder prevention;Distant Metastasis;drinking;East Asian;Environmental Risk Factor;epidemiologic data;Epstein-Barr Virus Infections;Etiology;European;Evaluation;Exposure to;Funding;Future;gastric cancer prevention;gastric carcinogenesis;Goals;Green tea;Health;Helicobacter Infections;Helicobacter pylori;high risk population;Human;improved;Individual;Infrastructure;innovation;insight;Intake;International;Investigation;lifestyle factors;Low Prevalence;male health;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediation;metabolome;metabolomics;Neoplasm Metastasis;Nested Case-Control Study;New York;novel;novel marker;Pathway interactions;Patients;Pilot Projects;Plasma;Play;Population;population based;Population Heterogeneity;Prevention;Processed Meats;Progestins;prospective;Prospective cohort;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Publishing;Regional Lymph Node Involvement;Reporting;Resources;response;Risk;Risk Assessment;Risk Factors;Role;Sampling;screening;Screening for Gastric Cancer;SEER Program;sex;Smoking;specific biomarkers;steroid hormone;Steroids;Stomach;stomach cardia;Survival Rate;Techniques;tool;tumor progression;United States;Universities;Validation;validation studies;Vegetables;Vitamin B 12 Deficiency;Women's Health;Work

PROJECT_TITLE: Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunization;Immunotherapy;Prevention;Women's Health Research

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: The intratumoral viral gene delivery containing a novel combination of herpes simplex virus -thymidine kinase gene (HSV-tk) and bifunctional antibody and prolongation of the gene expression may provide a novel and inexpensive therapeutic regimen, offering a truly transformative approach for cancer treatment.

PI_NAMEs: CHEN, SHU-HSIA  (contact);PAN, PING-YING

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Abscopal effect;Adenoviruses;Adverse event;Affect;Animals;antagonist;anti-cancer;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Benchmarking;Biodistribution;Bispecific Antibodies;Breast Cancer Patient;Cancer Detection;cancer subtypes;cancer therapy;Cancerous;CD40 Ligand;Cell Death;Cells;checkpoint therapy;chemotherapy;Clinical;Clinical Oncology;clinical translation;Clinical Trials;clinically relevant;Collaborations;cost;cytokine;Cytokine Activation;cytotoxicity;Dendritic Cells;dosage;experimental study;FDA approved;Future;Gene Delivery;Gene Expression;gene therapy;Genes;genetic signature;HSV-Tk Gene;Human;humanized mouse;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;Immunoglobulins;Immunologic Memory;Immunotherapeutic agent;Immunotherapy;improved;In Situ;In Vitro;Inflammatory;innovation;Kinetics;Laboratories;Leukocytes;Life;Ligands;Lymphoid Tissue;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modality;Modeling;mouse model;multidisciplinary;Mus;Myeloid-derived suppressor cells;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;new therapeutic target;novel;novel therapeutics;Organ;Orthologous Gene;patient derived xenograft model;Patients;Penetration;Phase;Phenotype;pre-clinical;prevent;Prodrugs;Production;programs;Property;Quality of life;Radiation;receptor;recombinant adenovirus;Recurrence;Regimen;relapse patients;Research;response;Shapes;Simplexvirus;Site;standard of care;success;suicide gene;T cell infiltration;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Index;Thymidine Kinase;Toxic effect;Training;transduction efficiency;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Validation;Viral;viral gene delivery;Viral Vector;Work

PROJECT_TITLE: Novel gene delivery to modulate the tumor microenvironment and antigen-specific antitumor immunity

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The conversion of somatic cells, specifically skin fibroblasts, into therapeutically beneficial cell types holds promising implications for the treatment of gastrointestinal and hepatic diseases. Nevertheless, current lineage reprogramming protocols often exhibit limited efficiency, and the resultant cells frequently fail to recapitulate the attributes of the intended cell type accurately. In this study, we propose to scrutinize the mechanistic intricacies of cell fate reprogramming by employing innovative experimental and computational genomic methodologies. Our objective is to elucidate the fundamental mechanisms underlying lineage reprogramming and leverage these insights to refine strategies for deriving human hepatic and intestinal cell types, thereby augmenting the potential for accurate disease modeling and effective therapeutic applications.

PI_NAMEs: MORRIS, SAMANTHA ANNETTE (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Address;Binding;Biological Assay;Cell Fraction;Cell Lineage;Cell Maturation;Cell Reprogramming;cell type;Cells;Chromatin;Clinical;Data;Derivation procedure;Development;Disease;disease model;Embryo;endodermal progenitor;Engineering;Engraftment;Exhibits;Fibroblasts;Funding;Gastrointestinal Diseases;Genes;Genetic;Genomics;Hepatic;Hepatocyte;Heterochromatin;Heterogeneity;Human;Human Biology;improved;In Vitro;innovation;insight;interest;Intestines;Knowledge;Liver;Liver diseases;Maps;Methodology;Molecular;multiple omics;Mus;novel;novel therapeutic intervention;Organ;Outcome;overexpression;permissiveness;pluripotency;Population;Population Heterogeneity;Process;programs;Protocols documentation;Reporting;Research;single cell ATAC-seq;single cell technology;Skin;Somatic Cell;Source;Specific qualifier value;stem cell differentiation;Stem Cell Research;Technology;Therapeutic;therapeutically effective;transcription factor;Translating;Transplantation;Work

PROJECT_TITLE: Decoding the Molecular Mechanisms Underlying Reprogramming to Functional Hepatic and Intestinal Cell Types

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Oxygen is administered to unconscious, critically ill patients on mechanical ventilation who have survived cardiopulmonary resuscitation (CPR) to keep them adequately oxygenated. Oxygen is not normally toxic at these concentrations but in this population of patients the threshold for oxygen toxicity is lowered resulting in increased brain injury and inflammation. This project investigates the molecular basis for increased oxygen toxicity following cardiac arrest and proposes therapeutic strategies to mitigates its effects.

PI_NAMEs: GARCIA, ALFREDO J;SHARP, WILLARD WILLIAM (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Address;Aerobic;aerobic glycolysis;Aging;Air;Animals;Antioxidants;Attenuated;barrier to testing;behavior test;Benign;Biological Markers;Blood flow;Brain;Brain Injuries;Breathing;Cardiac Myocytes;Cardiopulmonary Resuscitation;cell injury;Cells;Coma;Consumption;Coupled;Critical Care;Critical Illness;Data;Development;Encephalitis;Ensure;Environment;Glucose;Glycolysis;Goals;Heart;Heart Arrest;Heart failure;Heart Injuries;heart metabolism;HIF1A gene;Hour;Hyperoxia;Hypoxia;Hypoxia Inducible Factor;improved;improved outcome;in vivo;Inflammation;Inflammatory Response;Injury;Intubation;Knockout Mice;Knowledge;Label;Long-Term Potentiation;Malignant Neoplasms;Mechanical ventilation;Mediating;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Mitochondria;Molecular;mouse model;multiorgan injury;Myocardial;Myocardial dysfunction;myocardial hypoxia;Nervous System Trauma;Neurologic;Neurons;neurophysiology;new therapeutic target;normoxia;novel therapeutics;Organ;Outcome;oxidant stress;Oxygen;Oxygen Consumption;Oxygen Therapy Care;oxygen toxicity;Pathologic;Pathology;patient population;Patients;Pattern;pharmacologic;Physiological;Pilot Projects;Positron-Emission Tomography;prevent;Recommendation;Recovery;Recovery of Function;Research;Respiration;response;Resuscitation;Role;Secondary to;Signal Transduction;single photon emission computed tomography;Slice;Spectrophotometry;Stress;success;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;therapy outcome;Tissues;Toxic effect;transcription factor;Unconscious State;Warburg Effect;X-Ray Computed Tomography

PROJECT_TITLE: Resuscitating the Brain and Heart Following Cardiac Arrest: Targeting Oxygen Toxicity

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because the development of high-density, long-term neural recording tools has the potential to help us understand the fundamental mechanisms of neural circuitry in the brain and explore treatments of neurological conditions. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to the development of new biomedical techniques and devices that will improve the understanding, treatment, and prevention of disease.

PI_NAMEs: XIE, CHONG  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Aging;Animals;Behavior;biomaterial compatibility;Biophysics;Blood capillaries;Brain;Brain Stem;brain tissue;Chronic;Cicatrix;Clinical;Cognition;Collection;commercialization;Communication;Communities;Complex;Data;data acquisition;Data Set;data standards;Democracy;density;design;Deterioration;Development;Devices;Disease;disorder prevention;Electrodes;electronic data;Electronics;Electrophysiology (science);empowerment;experience;Extravasation;fabrication;Failure;flexibility;Foreign-Body Reaction;Hour;Human;Image;Implant;Implanted Electrodes;improved;in vivo;innovation;integrated circuit;Laboratories;Learning;Letters;Link;Manuscripts;Memory;meter;millisecond;Mission;Motion;Movement;Mus;nanoelectronics;Nerve Degeneration;neural;neural circuit;Neurologic;neuromechanism;Neurons;Neurosciences;neurotransmission;operation;Patients;Pattern;Perception;Performance;Polymers;Population;Preparation;Public Health;Rattus;Regenerative Medicine;Reliability of Results;Research;Research Support;Signal Transduction;Silicon;Site;Spinal Cord;stroke recovery;System;Techniques;Technology;temporal measurement;Thinness;Time;Tissues;tool;transmission process;two-photon;United States National Institutes of Health;Vision;wearable device;Wireless Charging

PROJECT_TITLE: A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural Recording


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Bacteroidales is the most abundant order of bacteria in the gut of most healthy humans where they provide numerous health benefits. This project will help us understand how these bacteria are able to persist over our lifetimes while delivering health promoting benefits in the constantly changing and challenging environment of the human gut.

PI_NAMEs: COMSTOCK, LAURIE E (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anti-Bacterial Agents;arm;Bacteria;Bacterial Toxins;Bacteroides;beta barrel;Biological;biological adaptation to stress;Biological Process;Biology;ChIP-seq;Colon;Communities;Data;Dedications;Disease;Ecosystem;EMSA;Environment;Escherichia coli;Exposure to;Family;fitness;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Gnotobiotic;gut bacteria;gut microbiota;Health;Health Benefit;Health Promotion;Human;in vivo;Knowledge;Ligands;Mediating;member;Membrane;Membrane Proteins;metabolomics;microbial;model organism;Molecular;multidisciplinary;Mus;mutant;Names;O Antigens;Operon;Organism;periplasm;Phenotype;Polysaccharides;Process;promoter;Property;Protein Family;protein function;protein protein interaction;Proteins;Regulation;Regulon;Reporter;Research;response;Role;Sigma Factor;Stress;stressor;structural biology;Techniques;Toxin;VDAC1 gene;Vesicle;Work;Xenobiotics

PROJECT_TITLE: Protective mechanisms of the gut Bacteroidales

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Macrophage fusion resulting in the formation of destructive multinucleated giant cells, accompany various disorders associated with chronic inflammation, including the long-term failure of implanted prosthetic vascular grafts and other medical devices. The proposed studies will determine why and how the fibrin polymer deposited on implanted biomaterials drives macrophage fusion and establish the cellular and molecular details of the recently discovered membrane protrusion that initiates macrophage fusion. The knowledge obtained from these studies will be employed to design new biomaterials with reduced macrophage fusion and test their properties in vivo animal models.

PI_NAMEs: UGAROVA, TATIANA P (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 3-Dimensional;Actins;adhesion receptor;Adhesions;Adhesives;Adsorption;Afibrinogenemia;Animal Model;Architecture;Artificial Implants;Attenuated;Automobile Driving;Biochemical;Biocompatible Materials;Biological;Biological Assay;Biology;Blood Vessel Prosthesis;CD18 Antigens;CD47 gene;Cell Adhesion;Cell fusion;Cells;Chronic;Complex;Data;Deposition;design;Disease;E-Cadherin;Epithelium;Failure;Fibrin;Fibrinogen;Filopodia;Foreign Bodies;Foreign-Body Reaction;Funding;Gel;Generations;Genetic;Giant Cells;Grant;Human;Hydrogels;Implant;In Vitro;in vivo;Inflammation;Injections;Integrins;interfacial;Invaded;knock-down;Knock-out;Knowledge;Lateral;live cell imaging;Macrophage;Macrophage-1 Antigen;mechanical properties;mechanotransduction;Mediating;Medical Device;medical implant;Membrane;Methodology;Microscopy;Modeling;Molecular;Molecular Conformation;Morphology;Mus;mutant;Myeloid Cells;nanoscale;nectin;novel;Pacemakers;Pattern;Physiological;polymerization;Polymers;Process;programs;Property;Prosthesis Implantation;Proteins;Recording of previous events;Research;Resolution;response;Role;self assembly;Signal Transduction;Site;Speed;Structure;Supporting Cell;Surface;Techniques;Testing;Time;Translating;Vascular Graft

PROJECT_TITLE: The role of beta 2 integrins in macrophage fusion


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Orphan Drug;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: PROJECT NARRATIVE We aim to determine the molecular requirements for healthy cardiac muscle function, in order to pave the way for discovery and design of more effective therapies for heart disease. Our work will answer crucial questions about how the protein myosin-binding protein C (MyBP-C), the leading cause of cardiomyopathy, functions in the heart, using reporter probes to visualize dynamic protein structures by testing its specific mechanistic roles in healthy and diseased heart cells. This research will greatly improve the human health prospects by understanding effects of disease mutations and developing tools that can be used to discover novel treatments.

PI_NAMEs: COLSON, BRETT A (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Address;Affect;Binding;Biological Assay;biophysical tools;Biosensor;Cardiac;cardiac muscle disease;Cardiac Myosins;Cardiomyopathies;Computer Simulation;Cyclic AMP-Dependent Protein Kinases;Data;Deceleration;design;Development;Disease;Disease Progression;Drug Targeting;effective therapy;Equilibrium;Evaluation;FDA approved;Fiber;Filament;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Foundations;Frequencies;Functional disorder;Genes;Health;Heart;heart cell;Heart Diseases;high throughput screening;Human;Hypertrophic Cardiomyopathy;improved;in silico;In Situ;In Vitro;Individual;Inherited;innovation;insight;Kinetics;Label;Lead;Location;Measurement;Measures;Mechanics;Mediating;Medical;Microfilaments;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;Mus;Muscle;Muscle function;mutant;Mutation;Myocardial;Myocardium;Myosin ATPase;myosin-binding protein C;N Domain;N-terminal;novel;novel therapeutics;Nucleotides;Pathologic;Performance;Pharmaceutical Preparations;Phosphorylation;Physiological;Pilot Projects;Positioning Attribute;Protein Dynamics;protein structure;Proteins;Publishing;Regulation;Relaxation;Reporter;Reporting;Research;Resolution;response;Role;Sarcomeres;simulation;Site;Skin;small molecule;Structure;Testing;Therapeutic;Thick;Thick Filament;Thin Filament;Thinness;Time;time use;tool;Visualization;Work

PROJECT_TITLE: Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-S (91)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Lung;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Preterm birth is common in the U.S., with tremendous impact upon children and families. While many go on to productive lives, growing evidence suggests adult disease manifestations for the formerly preterm—yet, we have limited understanding of the impact and mechanistic drivers among formerly preterm children (FPC). This proposal will expand the prevailing understanding of the impact of preterm birth even upon presumably ‘healthy’ children by determining the clinical, biochemical, and molecular characteristics of FPC to provide novel insights and potentially provide new therapeutic targets to modify before adulthood.

PI_NAMEs: AUSTIN, ERIC DOUGLAS (contact);COLLACO, JOSEPH MICHAEL;MCGRATH-MORROW, SHARON ANN

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: 12 year old;actigraphy;Adult;Age;Air Movements;airway obstruction;Biochemical;Biochemical Markers;Biological;Biological Markers;Blood specimen;Blood Vessels;Bronchopulmonary Dysplasia;burden of illness;cardiac magnetic resonance imaging;Cardiopulmonary;Caring;Characteristics;Child;Childhood;Chronic;Chronic Disease;Circulation;Classification;Clinical;clinical infrastructure;clinical phenotype;cohort;Data;Defect;Diabetes Mellitus;differential expression;Diffusion;Disease;early childhood;Early Intervention;Echocardiography;endophenotype;Energy Metabolism;Ethnic Origin;Exercise;Exercise Tolerance;F2-Isoprostanes;Family;Foundations;Functional disorder;Future;genetic signature;Gestational Age;Health;Human;hypertensive;IL8 gene;Immune response;Infant;Inflammation;Inflammatory;insight;Insulin;Insulin Resistance;Interleukin-6;Left;life span;Link;Live Birth;Longitudinal Studies;Lung;Measurement;Measures;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Modeling;Modification;Molecular;Molecular Profiling;Monitor;Morbidity - disease rate;new therapeutic target;novel;Obesity;Obstructive Lung Diseases;Outcome;Oxidative Stress;peripheral blood;Peripheral Blood Mononuclear Cell;personalized care;Phenotype;Predisposition;premature;Premature Birth;Premature Infant;Prevalence;primary outcome;Productivity;Publishing;Pulmonary function tests;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Race;Research Infrastructure;respiratory;Right Ventricular Function;Right ventricular strain;Risk;School-Age Population;sex;social health determinants;Social Interaction;social metrics;Stress;Survivors;Systemic hypertension;systemic inflammatory response;Testing;transcriptome sequencing;United States National Institutes of Health;Variant;Vascular Diseases;Ventricular;Walking;young adult

PROJECT_TITLE: Clinical and Biochemical Features of Metabolic Dysregulation in Formerly Preterm Children

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE  Clostridioides difficile spores are recognized as the morphotype of infection, persistence and transmission. Our proposed studies aim to understand the interactions between C. difficile spores and the host ́s intestinal mucosa that contribute to C. difficile persistence and recurrence of the infection. This research will reveal novel therapeutic targets from both, pathogen and host, to treat C. difficile infections and prevent disease recurrence.

PI_NAMEs: PAREDES-SABJA, DANIEL GONZALO (contact)

PROJECT_TERMS: Adherence;Adherens Junction;Affect;Anaerobic Bacteria;antibiotic-associated diarrhea;Antibiotics;Attenuated;Binding;Caveolae;Cecum;cell type;Cells;Cessation of life;Cholesterol;Clinical;Clostridium difficile;Colon;combat;Data;Death Rate;Diarrhea;Disease;E-Cadherin;Endocytosis;Endosomes;Epithelial Cells;Exposure to;extracellular;Extracellular Matrix Proteins;Fibronectins;Goals;Human;In Vitro;Infection;innovation;Integrins;intestinal epithelium;Intestinal Mucosa;Intestines;Knowledge;Laboratories;Lead;Ligands;Link;Mediating;Membrane Proteins;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Nystatin;pathogen;pathogenic bacteria;Pathway interactions;Patients;prevent;Pseudomembranous Colitis;receptor;Recurrence;Recurrent disease;recurrent infection;Reporting;Reproduction spores;Research;Role;Sampling;Signal Transduction;Surface;Symptoms;Taurine Cholate;Testing;Therapeutic;Tight Junctions;Toxin;trait;transmission process;vaccine strategy;Vancomycin;Virulence;Virulence Factors;Vitronectin

PROJECT_TITLE: Mechanisms of persistence of Clostridioides difficile in the intestinal mucosa

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative  Deposition of Amyloid beta (Ab) affects the microvasculature (MV) in Alzheimer’s disease and the related condition of Congophilic Amyloid Angiopathy (CAA). One sequelae of this deposition in or near the MV is alteration in collagen IV (Col IV), the primary structural protein in the MV basement membrane (BM). This proposal will examine the effect of Ab deposition on Col IV stability during disease progression in human and mouse models, and will define how different methods of removal of Ab could degrade Col IV and the MV BM leading to clinically significant damage such as MV disruption and microhemorrhage.

PI_NAMEs: REED, MAY J (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta deposition;Adhesions;Adverse effects;Affect;Age;Albumins;Alzheimer's Disease;Alzheimer's disease brain;Amyloid;Amyloid beta-Protein;amyloid imaging;Antibodies;Basement membrane;beta pleated sheet;Binding;Biochemical;Biochemical Process;Blood Vessels;Brain;brain control;cadherin 5;cerebral microvasculature;clinically significant;Collagen Type IV;Deposition;Disease Progression;Endothelium;Excision;Exposure to;Extracellular Matrix;Extravasation;Focal Adhesions;Foundations;Functional disorder;glycation;Hemorrhage;Human;human model;Image;Image Analysis;improved;in vivo imaging;inhibitor;insight;Integrins;Laminin;light microscopy;Measures;Mediating;Mediator;Metalloproteases;Methods;microvascular amyloid;Microvascular Dysfunction;MMP2 gene;Modeling;Modification;mouse model;Mus;neurovascular unit;Outcome;Peptides;Pericytes;Post-Translational Modification Alteration;Post-Translational Protein Processing;Process;repository;Safety;sex;small molecule;spatial relationship;Structural Protein;Structure;Time;TIMP1 gene;Tissues;Transmission Electron Microscopy;ultra high resolution;Ultrasonography

PROJECT_TITLE: Amyloid Beta and Collagen IV Interactions in the Brain Microvasculature in Alzheimers Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (55)]


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Lowe syndrome is a rare disease in boys that causes glaucoma and cataracts, kidney failure, intellectual disabilities, and seizures; there is no therapy for this severe vision- and life-threatening disease. In this proposal, we are developing several groundbreaking strategies using CRISPR-mediated gene therapy to rescue OCRL loss and serve as treatments for Lowe syndrome. The potential benefits of this proposed research include development of the first effective treatment for a rare but severe pediatric disease: a chance to save vision and prolong lives.

PI_NAMEs: SUN, YANG  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Adenine;Adenosine;Alleles;aqueous;base editing;base editor;BCAR1 gene;Bilateral;blind;Blindness;boys;Bypass;Cataract;causal variant;Cell model;Cells;Cessation of life;Child;Childhood;Cholesterol;Clustered Regularly Interspaced Short Palindromic Repeats;congenital cataract;CRISPR therapeutics;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cytoskeleton;Data;Defect;Development;Disease;disease model;Dominant-Negative Mutation;effective therapy;Endocytosis;Enzymes;exon skipping;Exons;Eye diseases;Foundations;Functional disorder;gain of function mutation;gene correction;Gene Mutation;gene therapy;Genes;Genetic;Genetic Transcription;genome editing;Glaucoma;Goals;Guide RNA;Hereditary Disease;Human;human induced pluripotent stem cells;Hydrophthalmos;In Vitro;in vivo;induced pluripotent stem cell;Inherited;innovation;Inositol;Inositol Metabolism Pathway;inositol-1,4,5-trisphosphate 5-phosphatase;insertion/deletion mutation;insight;Intellectual functioning disability;Kidney Failure;Laboratories;Life;Link;Lysosomes;Measures;Mediating;Mental Retardation;Methods;Missense Mutation;Modeling;mouse model;Mus;mutant;Mutation;Nonsense Codon;novel;novel therapeutic intervention;nuclease;Nucleotides;Oculocerebrorenal Syndrome;optic nerve disorder;Organ;paralogous gene;Patients;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Play;Positioning Attribute;Pre-Clinical Model;prime editing;prime editor;protein activation;protein expression;Protein Truncation;Publications;Rare Diseases;renal tubular dysfunction;Research;RNA Splicing;Seizures;Severity of illness;stem cells;targeted treatment;Techniques;Trabecular meshwork structure;Transcript;Transcriptional Activation;translational approach;Translations;Viral;Viral Packaging;Vision;Work;X Chromosome;Zebrafish

PROJECT_TITLE: CRISPR Based Rescue of Glaucoma in Lowe Syndrome

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative The kappa opioid receptor (KOR) is a highly desirable therapeutic target capable of treating not only pain but also affective disorders and addiction. Non-traditional signaling effectors and pathways underlying KOR activation play important roles in ligand-specific responses. Identifying the key triggers and mediators involved in KOR signaling will provide new routes for developing modulators of KOR as opioid alternatives.

PI_NAMEs: CHE, TAO  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: abuse liability;addiction;Address;ADRBK1 gene;Affect;alternative treatment;Arrestins;behavioral response;beta-arrestin;Binding;Biological Assay;Biology;Cause of Death;Cessation of life;Chemicals;Clinical;Complex;Coupled;Coupling;Data;design;Development;Effectiveness;Event;G-Protein-Coupled Receptors;Glutaminase;Goals;GRK5 gene;GTP-Binding Proteins;Guanosine Triphosphate;Individual;insight;kappa opioid receptors;Kinetics;Label;Ligands;Maps;Mass Spectrum Analysis;Mediating;Mediator;Molecular;molecular dynamics;Mood Disorders;mu opioid receptors;Mutagenesis;novel;Opioid;opioid overdose;Opioid Receptor;Outcome;Pain;Pain management;pain relief;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phosphorylation;Phosphotransferases;Play;protein function;protein protein interaction;Proteins;radioligand;receptor;Receptor Activation;receptor internalization;Receptor Signaling;recruit;Regulation;Reporting;response;Risk;Role;Route;Series;side effect;Signal Transduction;Signaling Protein;spatiotemporal;structural determinants;Structure;Testing;Therapeutic;therapeutic target;Time;tool;Transducers;Treatment Efficacy;Ventilatory Depression

PROJECT_TITLE: Mechanisms and Regulations of kappa Opioid Receptor Signaling

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative. We are developing a technology that will render the in-vivo measurement of creatinine, urea, and other uremic solutes as convenient as the continuous glucose monitor has rendered the measurement of blood sugar. By adding renal clearance to the list of vital signs that can be monitored unobtrusively and in real time, such an advance would speed the diagnosis and improve the treatment of acute kidney injury, and enhance the precision with which renal replacement therapies can be personalized to match the needs of individual patients.

PI_NAMEs: KIPPIN, TOD EDWARD (contact);PLAXCO, KEVIN W

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Animal Model;Animals;aptamer;Area;biomarker identification;Blood;Blood Glucose;Brain;Cerebrospinal Fluid;Clinical;clinical decision-making;Clinical Trials;Continuous Glucose Monitor;cost;Creatinine;Creatinine clearance measurement;Detection;Development;Diagnosis;Dialysis procedure;Effectiveness;End stage renal failure;Evaluation;Event;Frequencies;Goals;Heterogeneity;Hour;hydrophilicity;improved;improved outcome;In Situ;in vivo;individual patient;insight;Intercellular Fluid;invention;Kidney;Kidney Diseases;Kidney Failure;Manuals;Measurement;Measures;Methods;minimally invasive;Modeling;Molecular;Monitor;Muscle;Needles;Nephrology;novel strategies;Organ;Outcome;Patients;personalized medicine;Physiologic pulse;Physiological;Plasma;pre-clinical;preclinical study;Provider;Proxy;Quality of life;rate of change;real time monitoring;Renal clearance function;Renal function;Renal Replacement Therapy;Research;Resolution;response;sensor;Site;small molecule;Solid;solute;Speed;subcutaneous;success;support tools;Technology;temporal measurement;Testing;Time;Tissues;tool;Toxic effect;Toxin;Treatment Efficacy;Urea;Uremia;Validation;Vision;Work

PROJECT_TITLE: Comprehensive, Real-Time Monitoring of the Accumulation and Clearance of Small Molecules in Kidney Disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE This proposal aims to perform human immunologic studies to define immunoprotective role of skin B cells located at the forefront of host defense against HSV-2 and capable of producing antibodies able to prevent HSV-2 infection. The overall goal of the project is to identify critical, currently unidentified mediators of protection during infection and mechanisms of post-infection virus control. This work could lead to the development of a protective vaccine that eliminates the burden of HSV-2 worldwide.

PI_NAMEs: SHOLUKH, ANTON M (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Activities of Daily Living;Adult;Afferent Neurons;Antibodies;Antibody Repertoire;Antigenic Specificity;Antigens;B-cell receptor repertoire sequencing;B-Lymphocytes;Biological Assay;Biopsy;Blood Circulation;Bone Marrow;Cell Lineage;cell motility;Cell secretion;Cell Separation;Cells;Chronic;Circulation;Clinical;Clonal Expansion;Clone Cells;Containment;Data;deep sequencing;Dermis;design;Development;Disease;Disease Outbreaks;DNA;Epithelial Cells;Epitopes;Exhibits;experimental study;Frequencies;Future;Gene Expression Profile;Genetic Transcription;genital herpes;Genitalia;Goals;healing;Herpesviridae Infections;HIV;Host Defense;Human;Human Herpesvirus 2;human morbidity;Humoral Immunities;Immune;Immune response;Immunoglobulin Family Gene;Immunoglobulin Genes;Immunoglobulin-Secreting Cells;Immunologics;Immunotherapeutic agent;improved;Incidence;Individual;Infection;Infection Control;insight;keratinocyte;Lesion;Libraries;Link;mathematical model;Measures;Mediator;Microscopic;Modality;Monoclonal Antibodies;Natural History;neonatal infection;next generation;novel strategies;novel vaccines;Open Reading Frames;Output;Passive Immunotherapy;Persons;Plasma Cells;prevent;Primary Infection;Privatization;Residencies;Resolution;Resources;response;Risk;Role;Sampling;screening;Serology test;Serum;Sexually Transmitted Diseases;Simplexvirus;single-cell RNA sequencing;Site;Skin;skin biopsy;Specificity;Statistical Data Interpretation;Structure;synthetic biology;T cell response;T-Lymphocyte;Testing;Time;tissue resident memory T cell;Tissues;transcriptome;transcriptomics;United States;vaccination strategy;Vaccine Design;vaccine immunotherapy;Vaccines;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Role of local antibodies in control of chronic genital herpes

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BILLINGS

ORG_NAME: MONTANA STATE UNIVERSITY -BILLINGS

ORG_STATE: MT

PHR: Project Narrative: The biomedical research and practice fields are becoming increasingly reliant on the use of sophisticated analytical instrumentation, including UHPLC-QTOF (Ultra-High-Performance Liquid Chromatography-Quadrupole Time-of-Flight mass spectrometer). The high resolution and sensitivity of Agilent’s state-of-the-art 6530 QTOF MS integrated with Agilent’s equally advanced 1290 Infinity Series II UHPLC create a robust system capable of effective and precise analysis of complex biological samples, such as tissues, fluids or environmental samples, making identification of contaminants, toxins, or disease markers possible; high-resolution mass spectrometry continues to be a foundational approach to both small molecule and metabolic interaction identification in biomedical research. Knowing the fundamental operation and how to employ these sophisticated instruments in addressing biomedical-related concerns through monitoring, early detection, and accurate assessment of health risks, supporting public health initiatives and interventions.

PI_NAMEs: WILLEMS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Academia;Address;advanced analytics;Biodiversity;Biological;biomarker identification;Biomedical Research;care outcomes;Collaborations;community partners;Complex;Computer software;Critical Thinking;design;Detection;Development;Disease;drug discovery;Education;empowerment;experience;Fluorescence;Fostering;Funding;Future;Goals;health disparity;Health Personnel;Healthcare;High Pressure Liquid Chromatography;improved;Industry;industry partner;innovation;Institution;instrument;interdisciplinary collaboration;Interdisciplinary Study;Investigation;mass spectrometer;Metabolic;Montana;Native American population;next generation;novel;protein function;protein structure;Research;Research Personnel;Resources;Sampling;Scientific Advances and Accomplishments;Series;Students;System;Talents;Techniques;Technology;Time;Toxicology;tribal community;ultra high pressure;undergraduate student;underserved community

PROJECT_TITLE: Ultra High-Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer with UV-vis and Fluorescence Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Narrative: Everything we do is informed by our surroundings, but little is known about how sensory systems translate the complexity of natural ‘real world’ environments into meaningful neural codes. Our research will provide a comprehensive understanding of how the environment, sensory neurons, and motor action work together to drive optimal behavior. This knowledge is necessary to advance our understanding of chemosensation, neural coding, and how sensory systems function during natural behavior.

PI_NAMEs: STOWERS, LISA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Ablation;Acceleration;Accessory Olfactory Bulbs;Afferent Neurons;Aggressive behavior;Amaze;Anatomy;Animals;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;awake;Axon;Behavior;Behavioral;blind;Body System;Brain;Breathing;Child Rearing;Code;Complement;Cues;Data;Data Set;desensitization;Detection;Endoscopes;Environment;Esthesia;Evolution;Experimental Models;Feces;flexibility;foxes;Fright;Functional disorder;Genetic;Goals;Head;Human;Image;Individual;insight;Kairomones;Knowledge;Ligands;Logic;Measures;Mediating;Mental Depression;Methods;Modeling;Monitor;Motor;Mus;mutant;neural;neuromechanism;Neurons;Neurosciences;Nose;Odors;olfactory bulb glomeruli;Olfactory Pathways;Partner in relationship;Pheromone;Property;Publishing;receptor;Research;response;Retinal blind spot;Sense Organs;sensor;Sensory;sensory system;sex;Smell Perception;Social Behavior;social communication;Social Interaction;Stimulus;Structure;success;System;Taste Perception;Testing;Translating;Vertebrates;Volatilization;vomeronasal organ;Work

PROJECT_TITLE: Decoding vomeronasal activity through awake, behaving AOB imaging.

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric;Prevention

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Early childhood education programs can influence a host of developmental outcomes through their provision of stimulating learning spaces, nutritious meals, screening for vision, hearing, health, and developmental difficulties, and by providing safe and reliable childcare that enables parents to work or further their education. However, most pre-kindergarten evaluation studies examine academic achievement outcomes alone, leaving a large gap in our understanding of how early learning interventions affect child health and family well-being. We will be the first to evaluate the impact of state pre-k investments over the past 20 years on a comprehensive set of child and family outcomes, including child physical and mental health, and maternal mental health and employment, to test whether pre-kindergarten investments have broad impact and to determine the pathways through which children develop.

PI_NAMEs: JENKINS, JADE VANESSA MARCUS (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Achievement;Affect;Anxiety;Basic Science;Buffers;Caring;Characteristics;Child;Child Care;Child Development;Child Health;Child Welfare;Communities;comparative;County;COVID-19 impact;COVID-19 pandemic;Data;data integration;Data Set;Data Sources;Development;disability;early childhood;econometrics;Economic Conditions;Education;Educational Curriculum;elementary school;Eligibility Determination;Employment;Ensure;Environment;Equity;Ethnic Origin;Ethnic Population;Evaluation;Evaluation Studies;experience;Family;fifth grade;Funding;Future;graduate school;Health;Hearing;high school;Hybrids;improved outcome;Income;innovation;Instruction;instrument;Intervention;Investments;K-12 Education;Latino;Learning;learning outcome;Location;marginalized population;Matched Group;Mental Health;Methods;Mothers;National Institute of Child Health and Human Development;North Carolina;novel;Nursery Schools;Nutritional;Outcome;pandemic disease;pandemic impact;Parents;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Policies;post-COVID-19;Privatization;programs;protective effect;Public Policy;Qualifying;Race;racial population;Role;Running;scale up;Schools;Shock;Site;Students;Subgroup;teacher;Testing;theories;Time;Variant;Vision Screening;Work

PROJECT_TITLE: Factors in Persistence Versus Fadeout of Early Childhood Intervention Impacts

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]