NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Sleep Research;Tobacco

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The proposed K99 study will leverage integrative data analysis to identify potential risk mechanisms (attention, motor, and sleep behavior) associated with behavior dysregulation in infants exposed to nicotine in utero and in unexposed infants. The R00 study will expand on this foundational knowledge to longitudinally characterize attention, motor, and sleep behavior earlier in development—across the first postnatal year—associated with parent-reported behavior dysregulation at 1-year of age, using sensitive, automated, and scalable measures. By charting these trajectories of risk, we can uncover the emergence of neurodevelopmental dysregulations and potential etiological pathways to help inform prevention and intervention efforts.

PI_NAMEs: MAYLOTT, SARAH E. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 1 year old;3 year old;Age;Age Months;Arousal and Regulatory Systems;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior assessment;Behavior Disorders;Behavioral;behavioral phenotyping;Behavioral Symptoms;Birth;Caregivers;causal model;Child;Childhood;Classification;Clinical assessments;clinical development;Code;Cognitive;cognitive system;cohort;comorbidity;Data;Data Aggregation;Data Analyses;data harmonization;Data Set;Development;Diagnosis;Diagnostic;Disease;early childhood;Early identification;Etiology;Exhibits;Foundations;Future;Genetic Risk;Goals;Heterogeneity;Human;in utero;infancy;Infant;insight;Intervention;Knowledge;Life;Manuals;Measures;Mentors;Methodology;Methods;Middle Insomnia;modifiable behavior;modifiable risk;motion sensor;Motor;motor behavior;National Institute of Mental Health;neurobehavioral;nicotine exposure;novel;Nursery Schools;opioid exposure;Outcome;Parents;Pathway interactions;Pattern;Phenotype;phenotypic biomarker;Play;Populations at Risk;postnatal;predictive marker;Pregnancy;Premature Infant;prenatal nicotine exposure;prevent;Prevention;programs;Psychopathology;recruit;Reporting;Research;Research Domain Criteria;Research Personnel;Risk;Risk Behaviors;Risk Factors;risk prediction;Sampling;sensorimotor system;Sensory;Sleep;sleep behavior;Sleep disturbances;sleep onset;sleep pattern;Standardization;Subgroup;sustained attention;Symptoms;Techniques;Technology;Time;Toddler;Training;Training Support;treatment response;visual tracking;wearable device

PROJECT_TITLE: Characterizing early signs of neurobehavioral dysregulation in infants at increased risk for behavioral disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (05)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Digestive Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Liver Cancer;Liver Disease;Lung;Lung Cancer;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The mission of the Massey Cancer Center (MCC) is to reduce the state cancer burden for all Virginians by addressing the confluence between biological, social, and policy drivers through high-impact, cutting-edge research; person-centered care across the continuum, from prevention through survivorship; community integration; and training the next generation of community-centric researchers and healthcare professionals. The core of this mission has been supported by the National Cancer Institute’s Cancer Center Support Grant (CCSG) since 1975, and the MCC is seeking renewal of this award for another five years. The CCSG supports efforts across the MCC senior and programmatic leadership; administration; community outreach and engagement; cancer research training and education coordination; promotion of center-wide diversity, equity, and inclusion; shared resource support and management; clinical research infrastructure; and developmental funding to supporting team-based, transdisciplinary research strategies focused on well-defined, catchment area priorities.

PI_NAMEs: WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Academia;Academic Medical Centers;Address;African American;age effect;Aging;AIDS related cancer;Algorithms;anti-cancer research;Appointment;Area;authority;Award;Basic Science;Behavioral;Biological;Biometry;Black race;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Cancer Survivorship;cancer therapy;career development;Caring;Catchment Area;Cells;Charge;Cities;Clinical;clinical implementation;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;college;Communities;Community Clinical Oncology Program;community engagement;Community Integration;Community Outreach;County;Crime;data acquisition;Data Analyses;Death Rate;Development;Developmental Therapeutics Program;Disparity;driving behavior;Education;Education and Outreach;electronic medical record system;Ensure;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Excess Mortality;Faculty;fitness;Flow Cytometry;Fostering;Funding;Geography;Goals;Growth;Health;health disparity;Health equity research;Health Policy;Health Professional;Health Promotion;Health system;HIV Infections;Home;Hot Spot;Housing;improved;Incidence;Individual;innovation;Institution;Intervention;Intervention Trial;Investments;Knockout Mice;Leadership;lipidomics;liver cancer patient;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;medically underserved;member;Mentors;metabolomics;Methodology;Microscopy;Mid-Atlantic Region;Minority;Mission;Modeling;multidisciplinary;National Cancer Institute;neighborhood disadvantage;next generation;Obesity;Outcome;Patient Care;Peer Review;person centered;Policies;Population;Population Sciences;Positioning Attribute;Poverty;Prevention;Prevention approach;Primary Care;Production;Productivity;programs;Publications;Race;racial minority;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Rural;rural area;Schools;Science;Scientist;Screening for cancer;Services;Smoking;smoking-related cancer;social;social health determinants;socioeconomic diversity;socioeconomics;Specialist;Speed;Strategic Planning;Students;success;survivorship;Technology;Tissues;Tobacco;Training;Training and Education;Transgenic Organisms;Translations;tumor microenvironment;Underrepresented Minority;underserved area;United States Health Resources and Services Administration;Universities;Virginia;Vision

PROJECT_TITLE: The impact of age and HIV infection on the cellular fitness of tumor microenvironment cells in liver cancer patients (HIV-Associated Cancers in Aging Populations)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE  The earliest symptoms in most of Alzheimer's disease (AD) patients is olfactory dysfunction, but AD's olfactory impairment is still poorly studied. The current study aims in identifying how the connectivity of olfactory circuits to the memory circuits are disrupted in early AD by using non-invasive structural and functional biomarkers in relation to behavioral deficits in memory and smell. Identification of early AD biomarkers by multi- modal MRI, as we propose to do in this application, will provide the best opportunity for effective early intervention to treat the disease before disabling symptoms appear.

PI_NAMEs: GANGANNA, BASAVARAJU SANGANAHALLI (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;Age;aged;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;amyloid formation;Anatomy;Area;Behavior;behavior measurement;behavior test;Behavioral;Behavioral Assay;behavioral study;Biological Markers;Brain;Brain region;Cerebral cortex;Cessation of life;Clinical;Cognitive;Defect;Dementia;Detection;Development;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;disabling symptom;Disease;Disease Progression;Early Diagnosis;Early identification;Early Intervention;Early Onset Alzheimer Disease;Energy Metabolism;entorhinal cortex;Evaluation;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Hippocampus;Human;Human Amyloid Precursor Protein;Image;imaging biomarker;imaging study;Impaired cognition;Impairment;in vivo;innovation;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Maps;Measurement;Measures;Memory;Memory impairment;method development;Methodology;Methods;Mitochondria;mitochondrial metabolism;Modeling;Monitor;multimodality;mutant;Neurodegenerative Disorders;neuroimaging;neuropathology;Neurotransmitters;Nicotinamide adenine dinucleotide;novel;object recognition;Odors;olfactory bulb;Olfactory Cortex;Olfactory dysfunction;Olfactory Learning;Olfactory Pathways;Oxidation-Reduction;oxidative damage;Pathologic;piriform cortex;potential biomarker;pre-clinical;Pre-Clinical Model;Production;progressive neurodegeneration;Rattus;Research;response;Rest;Retrieval;Rodent Model;Senile Plaques;Site;Smell Perception;spatial memory;spectroscopic survey;Staging;Symptoms;System;tau aggregation;Techniques;Testing;Therapeutic Intervention;therapy development;tool;Transgenic Organisms;Translating;transmission process;Work

PROJECT_TITLE: Identification of early markers for Alzheimer's disease by neuroimaging

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Psychosis;Rural Health;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PI_NAMEs: WOODBERRY, KRISTEN ANNE (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: acute care;Address;Adolescent;Adolescent and Young Adult;Age;aged;Agreement;attenuated psychosis syndrome;automated analysis;Caring;Centers of Research Excellence;Clinical;Collaborations;Communities;Data;design;Development;Diagnosis;Early Intervention;Electronic Health Record;Evidence based intervention;fifth grade;Goals;high risk;improved;improved outcome;Individual;Interview;Life;Maine;Measurement;Measures;Medical Records;Mental Health;Mental Health Services;Minority;Modeling;Outcome;Patient Self-Report;Performance;Primary Care;primary care patient;primary care practice;primary care setting;Protocols documentation;Psychometrics;Psychoses;psychotic;Psychotic Disorders;rapid detection;Reading;recruit;Research;Rural;Rural Community;rural disparities;Sampling;Schizophrenia;screening;Screening procedure;sociodemographics;Speech;Standardization;Structure;Symptoms;Testing;Time;tool;Triage;Validity and Reliability;Writing;young adult;Youth

PROJECT_TITLE: Developing Universal Psychosis Screens for Use With Maine Youth in Primary Care


ORG_CITY: SEATTLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE TRPV1-2 and TRPM2 ion channels are multimodal sensors that transduce a variety of signal modalities into electrical signals to allow cells to adapt to their changing environment. In this proposal, we will use a combination of patch-clamp electrophysiology and fluorescence lifetime imaging microscopy to measure the energetic coupling between the sensing modules and the channels’ gates and among different sensing modules to explain the molecular mechanisms by which environmental signals control the gating process.

PI_NAMEs: GORDON, SHARONA E (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biology;Capsaicin;Cells;Chemicals;conformational conversion;Coupled;Coupling;Electrophysiology (science);Environment;fluorescence lifetime imaging;Goals;Heterogeneity;innovation;Integral Membrane Protein;Ion Channel;Ions;Lipids;Measures;Mechanics;Membrane;Menthol;Modality;Molecular;Molecular Conformation;multimodality;Natural Products;Nutrient;Optics;patch clamp;Process;protein function;Proteins;sensor;Signal Transduction;Stimulus;sulfated glycoprotein 2;System;Time;tool;TRP channel;TRPV1 gene

PROJECT_TITLE: Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Latinx adolescents, especially those from mixed-status families (where one or both parents are undocumented), experience increased levels of depressive symptoms when compared to youth from other ethnic-racial groups, but they face several barriers to receiving mental health care, such as individual and cultural stigma, low levels of mental health literacy, concerns about protecting the safety of their undocumented parents, and reluctance to discuss their mental health needs with their parents or other adults. To receive care, these teens need to overcome these barriers. This project will develop, pilot, and evaluate an intervention specifically geared to Latinx adolescents from mixed-status families aimed at increasing youth discussions of their mental health needs with parents or other trusted adults, lowering mental health stigma, improving mental health literacy, and increasing their access to mental health care.

PI_NAMEs: CROSS, FERNANDA LIMA (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Adolescence;Adolescent;adolescent mental health;Adult;Affect;Age;Anxiety;Awareness;Behavioral;career;career development;Caregivers;Caring;Child;Clinical;clinical trial analysis;Communication;Communities;community based participatory research;Community Health Aides;community intervention;community setting;Coupled;Data;depressive symptoms;design;Development;Discrimination;Educational workshop;Ethnic Origin;Evaluation;Exhibits;experience;Face;Family;Feedback;Feeling;Focus Groups;Future;Goals;Grant;Health;health care availability;health communication;Health Insurance;health literacy;Health Services Accessibility;Healthcare;high school;Home;Immigrant;Immigrant community;implementation intervention;implementation science;improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;Language;Latinx;Left;literacy;Manuscripts;marginalized population;Medicine;member;Mental Depression;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Methods;Michigan;Modeling;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;Outcome;Parents;Population;primary outcome;protective factors;psychological violence;psychosocial outcome;psychosocial wellbeing;Public Health;Race;racial population;randomized, clinical trials;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk Factors;Safety;School-Age Population;Schools;secondary outcome;Self Determination;Services;skill acquisition;skills;social culture;social health determinants;social stigma;Social Work;Statistical Data Interpretation;Stress;symposium;Symptoms;Teenagers;Testing;theories;therapy development;Training;Translational Research;Trust;Universities;Work;Youth

PROJECT_TITLE: Enlace Familiar: Combating Mental Health Stigma, Improving Mental Health Literacy, Supporting Mental Health Discussions at Home, and Access to care among Latinx Adolescents from Mixed Status Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE No changes from parent grant. See Supplement Research Plan for supplement specific information.

PI_NAMEs: CHRISTIAN, LISA MICHELLE (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: age acceleration;Dementia caregivers;parent grant;Research;Risk

PROJECT_TITLE: Spousal dementia caregivers: Risk for accelerated aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA CITY VA MEDICAL CENTER

ORG_STATE: OK

PHR: The demographics of the veteran population clearly demonstrate that illnesses afflicting the elderly are a major concern of the Department of Veterans Affairs. Currently, the number of veterans over 50 years of age represents over 70% of the total veteran population. Research has shown that chronic, low-grade inflammation increases dramatically with age and that inflammation is a major risk factor for a variety of age- related diseases that affect elderly veterans, especially neurogenerative diseases like Alzheimer's disease. The research in this application will study a novel mechanism involved in neuroinflammation: the activation of necroptosis specifically in neurons is proposed to induce the release of necroptotic extracellular vesicles from neurons that activate microglia and astrocytes leading to neuroinflammation, which results in neuronal dysfunction and reduced cognition. Data from this project has the potential of leading to new therapies to treat neurodegeneration and the loss of cognition that occurs with age in elderly veterans.

PI_NAMEs: RICHARDSON, ARLAN G. (contact)

PROJECT_TERMS: Adult;Affect;Age;age related;Age Years;age-related disease;aging brain;aging related;Alzheimer's Disease;Astrocytes;Attenuated;Binding;Brain;Brain region;Calcium;Cell Culture Techniques;Cell Death;Cell membrane;cell type;Cells;Cessation of life;chemokine;Chronic;Cognition;conditioned fear;cytokine;Cytolysis;Data;demographics;Disease;Elderly;experimental study;extracellular vesicles;Gene Expression;Generations;Grant;hallmarks of aging;Hippocampus;Immune;Impaired cognition;improved;Induced Neurons;Inflammaging;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Knock-in Mouse;Knockout Mice;Knowledge;Link;Long-Term Potentiation;Measures;Microglia;military veteran;Molecular;Morbidity - disease rate;morris water maze;mortality;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;novel;novel therapeutics;object recognition;old mice;overexpression;Pathway interactions;Pattern;Phosphorylation;Population;prevent;Research;response;RIPK1 gene;RIPK3 gene;Risk Factors;Role;Rupture;single-cell RNA sequencing;Slice;Stimulus;targeted treatment;Testing;Time;Tissues;transcriptome;transcriptomics;Transgenic Mice;Transgenic Organisms;United States Department of Veterans Affairs;Veterans;Wild Type Mouse

PROJECT_TITLE: Effect of Necroptosis in Neurons on Neuroinflammation, Neuronal Function, and Cognition

STUDY_SECTION_NAME: Neurobiology 2 Integrated Review Group[NB2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Current surveillance and reporting approaches for the epidemic of substance use (SU) and substance use disorder (SUD) involve substantial lags, necessitating the need for the development of effective and innovative surveillance strategies. Social media encapsulates an abundance of data about SU/SUD reported by people from diverse subpopulations, making it possible to obtain insights into emerging substances that have limited data available from traditional settings. In this supplement, we will utilize our existing data science infrastructure (natural language processing and machine learning) to conduct detailed analyses of information on xylazine, posted by people with lived experiences in social media platforms.

PI_NAMEs: SARKER, ABEED H (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Address;Advanced Development;Adverse effects;Adverse event;analog;Area;Artificial Intelligence;artificial intelligence method;Big Data;Big Data to Knowledge;biomedical informatics;Calibration;Cessation of life;Clinical;cohort;Collaborations;Complex;cost;COVID-19 pandemic;dashboard;Data;data access;data analysis pipeline;data dashboard;data mining;Data Science;data science infrastructure;data visualization;deep neural network;Detection;Development;Disparity;Drug Prescriptions;Drug user;Ecosystem;Elements;Emergency Medicine;empowerment;Encapsulated;Epidemic;ethnic minority;experience;Expert Systems;Fentanyl;fentanyl analog;Funding;Future;Generations;generative artificial intelligence;Geographic Locations;Helping to End Addiction Long-term;Illicit Drugs;improved;Information Retrieval;Infrastructure;innovation;insight;interest;Intervention;Journals;Knowledge;Language;large language model;Lived experience;Longitudinal Studies;Longitudinal trends;Machine Learning;machine learning method;Mentorship;Methamphetamine;Methods;Mining;Modeling;National Institute of Drug Abuse;Natural Language Processing;novel;novel strategies;Opioid;opioid epidemic;opioid user;Outcome;Output;overdose death;Paper;parent grant;Parents;Persons;Policy Making;Population;Population Group;Process;psychostimulant;Public Health;Publishing;racial minority;real time monitoring;Reporting;Research;Research Personnel;Resources;response;shot learning;skills;Social Impacts;social media;social stigma;Source;Stigmatization;Stream;substance use;Substance Use Disorder;surveillance strategy;synthetic opioid;Target Populations;Time;Training;trend;Twitter;United States;Work;Xylazine

PROJECT_TITLE: Diversity Supplement for Mining Social Media Big Data for Toxicovigilance


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

ORG_STATE: NY

PHR: This proposal describes the need for and outline of an RM1 BTDD Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) situated at the New York Structural Biology Center. The focus of CoMD/NMR is to facilitate access to and adoption of cutting-edge technologies of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes, emphasizing functional aspects of oligomerization or assembly and of ligand recognition. The objectives of this proposal impact a diverse range of biological research with human health relevance, including cell signaling (in cancer and cell death pathways), degenerative diseases, metabolic disorders, and cancer. Project Narrative Page 7

PI_NAMEs: PALMER, ARTHUR G (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adoption;Automobile Driving;Biological Process;biological research;Biomedical Technology;Biopolymers;Catalysis;Cell Death;Communities;community engagement;Community Health Education;Community Outreach;Computational Technique;Computing Methodologies;Cryoelectron Microscopy;data acquisition;Data Analyses;Degenerative Disorder;Environment;Equipment;experimental study;Freezing;Health;Human;instrument;instrumentation;Ligands;magnetic field;Malignant Neoplasms;Membrane Proteins;Metabolic Diseases;Methods;Mission;Modernization;Nature;New York;NMR Spectroscopy;Nuclear;Nucleic Acid Conformation;Pathway interactions;Physiologic pulse;pressure;Production;program dissemination;programs;Proteins;Relaxation;Research;Research Personnel;Services;Signal Transduction;solid state nuclear magnetic resonance;Strategic Planning;structural biology;Structure;synergism;Technology;technology development;Technology Transfer;Time;Training;Work;X ray diffraction analysis

PROJECT_TITLE: RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement Request

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cancer cells that display profound genome instability have often lost their ability to repair chromosome double-strand breaks (DSBs) by the accurate processes of homologous recombination; they also have lost their ability to activate the DNA damage response, which arrests cell cycle progression. This proposal investigates the mechanisms of repairing DSBs by homologous recombination and the interrelationship between DNA repair and the DNA damage response, primarily using budding yeast. This grant will also allow investigation of the poorly understood homologous recombination mechanisms that underlie the ability of the Lyme disease bacterium, Borrelia burgdorferi, to escape immune surveillance.

PI_NAMEs: HABER, JAMES E (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Area;Bacteria;Biochemistry;Biological Models;Borrelia;Borrelia burgdorferi;cancer cell;Cell Cycle Arrest;Cell Cycle Progression;Cells;Chromosomal Breaks;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;DNA Damage;DNA damage checkpoint;DNA Repair;Double Strand Break Repair;Event;Funding;Gene Conversion;Genes;Genetic Recombination;Genomic Instability;Goals;Grant;homologous recombination;Human;Immunologic Surveillance;in vivo;insight;Investigation;Lyme Disease;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;Monitor;Mutation;National Institute of General Medical Sciences;Process;Pseudogenes;repaired;Research;response;Saccharomycetales;Signal Transduction;Single-Stranded DNA;Site

PROJECT_TITLE: DNA damage response and repair of a broken chromosome

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Neurons of the spiral ganglion, which transmit sound stimuli, can be permanently lost following damage or due to aging. Proposed studies aim to establish the zebrafish lateral line ganglion, which regenerates following damage, as a model for spontaneous regeneration studies. Such studies will be useful in developing methods for endogenous neuronal regeneration in the inner ear.

PI_NAMEs: SHEETS, LAVINIA  (contact);WARCHOL, MARK

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Acoustic Nerve;Afferent Neurons;Age;Aging;Animals;Auditory;Biological Models;bone;Brain Stem;Cell division;cell injury;cell type;Cells;chemical genetics;Clinical;Cochlea;Cochlear Implants;Data;defined contribution;Development;Equilibrium;Event;experimental study;Fishes;fluorescence imaging;Fluorescent in Situ Hybridization;Ganglia;ganglion cell;Genes;genetic resource;Genetic Transcription;Growth;Hair Cells;Hearing;Human;in vivo Model;Individual;Induced Neurons;Injury;interest;Intermediate Filament Proteins;Label;Labyrinth;lateral line;Lesion;Macrophage;Maintenance;Mammals;Mediating;method development;Methods;Modeling;Mus;Natural regeneration;nerve stem cell;nestin protein;neurogenesis;neuron development;neuron loss;neuron regeneration;neuronal cell body;Neuronal Injury;neuronal patterning;neuronal replacement;Neurons;neurotransmission;noise exposure;normal aging;Optics;Organ;Otic Vesicle;ototoxicity;Outcome Study;Pattern;permissiveness;Phenotype;Population;precursor cell;Process;Production;progenitor;Proliferating;Reaction;regenerative;Regenerative research;Regenerative response;repaired;response;Role;Sensorineural Hearing Loss;Sensory;Sensory Ganglia;sensory system;Signal Transduction;Signaling Molecule;single molecule;sound;spiral ganglion;stem cell division;stem cell proliferation;stem cell self renewal;stem cells;Stimulus;Study models;Synapses;Testing;Tissues;transcription factor;transmission process;vestibular system;Visualization;Wallerian Degeneration;Zebrafish

PROJECT_TITLE: Development of an in vivo model system of sensory afferent neuron regeneration

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project narrative Motile leukocytes in the innate immune system defend our body against viruses, bacteria, and cancer cells. Understanding the cell signaling mechanisms that regulate leukocyte motility could open doors for researchers to develop therapeutics that modulate immune cell functions in order to combat cancer, infection, and inflammation.

PI_NAMEs: HANSEN, SCOTT DAVID (contact)

PROJECT_TERMS: Bacteria;Behavior;Biochemistry;Biophysics;Biosensor;cancer cell;Cell membrane;cell motility;Cell Physiology;Cell Surface Receptors;Cells;Cellular biology;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Coin;combat;Communication;Cues;Decision Making;Environment;Enzymes;fluorescence imaging;genome editing;Goals;Guanosine Triphosphate Phosphohydrolases;Human;Immune;immune modulating agents;immunoregulation;In Vitro;Infection;Inflammation;Innate Immune System;Knowledge;Leukocytes;Lipids;live cell imaging;Malignant Neoplasms;Membrane;migration;Molecular;molecular imaging;Monomeric GTP-Binding Proteins;Motility;Movement;neutrophil;novel therapeutics;optogenetics;Pathogenicity;Phosphatidylinositol Phosphates;Phosphoric Monoester Hydrolases;Proteins;reconstitution;recruit;Regulation;Research;Research Personnel;Role;scaffold;Signal Transduction;Signaling Molecule;single molecule;Source;Techniques;Technology;tool;Travel;Virus

PROJECT_TITLE: Deciphering the mechanism of SHIP1 regulation in human neutrophils

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative Most caregiving responsibilities for persons with Alzheimer’s disease and related dementias (ADRD) fall on their family members. An improved assessment of caregiving processes and their relationship to caregiving outcomes is vital to be able to properly support ADRD caregiving families.

PI_NAMEs: PICKERING, CAROLYN E ZIMINSKI (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Activities of Daily Living;Alzheimer's disease related dementia;Black Box;Care given by nurses;care outcomes;care recipients;Caregivers;caregiving;caregiving outcomes;Caring;contextual factors;Data;data-driven model;Decision Making;design;Development;diaries;Discipline of Nursing;driving force;Elder Abuse;Enrollment;Equation;Event;experience;Failure;falls;Family Caregiver;family caregiving;Family member;Formal caregiver;Future;Guidelines;Health Services;Health Services Research;Health system;improved;innovation;insight;instrumental activity of daily living;Intervention;Interview;Knowledge;Left;Life;Light;longitudinal design;Measures;Methods;Modeling;neglect;novel;Nurses;Outcome;Participant;Patient Self-Report;Perception;Persons;Physiological;Policies;Process;psychologic;Quality of Care;recruit;Research;Resources;Responsible Person;Sampling;Self Care;Stress;Surveys;Testing;Theoretical model;theories;Time;Work

PROJECT_TITLE: Missed Care in Family Caregiving for Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(02)]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: Watsonville

ORG_NAME: EDUCATION, TRAINING, & RESEARCH ASSOCS

ORG_STATE: CA

PHR: Project Narrative Connections for Health: Centering school connection and health for rural young people project is designed to address health inequities among rural young people through school-based health education. The two major components of the project are: 1) an evidence-informed, skills-based comprehensive health education program that is tailored to the needs of rural communities and addresses social and emotional skill development in addition to health and sexual health; and 2) a comprehensive professional development program that supports teachers in addressing the complex needs of rural students and supports their own wellness. This project will help build the evidence base for school-based strategies that promote the health and well-being of rural young people.

PI_NAMEs: KOSCIW, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: RFA-DP-24-138, Connections for Health: Centering school connection and health for rural young people

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (11)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PI_NAMEs: BURNETTE, PEARLIE K (contact)

PROJECT_TERMS: Adult;Age;biobank;Biological Assay;Biological Specimen Banks;Clinical;Collection;Communities;Contracts;Data;Data Coordinating Center;data repository;data resource;Data Set;design;Dysmyelopoietic Syndromes;electronic data;Equipment;Equipment and supply inventories;Funding;Knowledge;Laboratories;laboratory facility;member;National Heart, Lung, and Blood Institute;Natural History;Newly Diagnosed;Observational Study;Participant;programs;Protocols documentation;Research;Services;Syndrome;Technical Expertise;Writing

PROJECT_TITLE: IGF::OT::IGF THE NATIONAL MYELODYSPLASTIC SYNDROMES (MDS) NATURAL HISTORY STUDY, CENTRAL LAB AND BIOREPOSITORY (CLB), TASK ORDER 03, SEPTEMBER 1, 2016-FEBRUARY 28, 2018


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases;Women's Health Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: FREEDMAN, LEONARD  (contact)

PROJECT_TERMS: Affect;Biological;cancer genetics;Cancer Intervention;cancer risk;case control;Case/Control Studies;cohort;Collaborations;Complex;Data;data access;Data Set;deep sequencing;Diagnostic;Disease;disorder risk;Division of Cancer Epidemiology and Genetics;DNA;Ensure;epidemiology study;Extramural Activities;gene environment interaction;Genes;Genetic Markers;Genetic Predisposition to Disease;genetic variant;Genome Scan;genome wide association study;Genomics;Individual;Inherited;large datasets;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Persons;Phenotype;Pilot Projects;Population Study;Predisposition;Preventive;Private Sector;programs;Research;Research Personnel;Resources;Risk;Scanning;Scientist;Series;Techniques;Therapeutic Intervention;trait;United States National Institutes of Health;Variant

PROJECT_TITLE: DCEG- GWAS Studies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Infectious Diseases;Prevention

PROJECT_TERMS: Affect;alpha Tocopherol;American Cancer Society;anti-cancer research;Area;Basic Science;Beta Carotene;bioinformatics pipeline;Biological Assay;Cancer Burden;cancer genomics;cancer prevention;Cervical Cancer Screening;clinically relevant;cohort;Colon;cost;Custom;Data;data access;Data Analyses;Data Storage and Retrieval;database of Genotypes and Phenotypes;design;Development;digital;digital pathology;Disease;Disease Outcome;Division of Cancer Epidemiology and Genetics;DNA;Electronics;Employment;Environmental Risk Factor;Epidemiologist;epidemiology study;exome;exome sequencing;Experimental Designs;Family;follow-up;Generations;Genes;Genetic;genetic epidemiology;Genetic Markers;genetic variant;Genetic Variation;Genome Scan;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Heritability;Human Genome;human genomics;Human Papillomavirus;Image;Immunohistochemistry;Individual;Informatics;Information Management;interest;Intramural Research Program;Laboratories;Laboratory Research;Lung;Malignant Neoplasms;Meta-Analysis;Molecular Epidemiology;molecular pathology;Mutation;Normal tissue morphology;novel;Nucleic Acids;Outcome;Ovarian;Phenotype;Population;Population Group;Predisposition;Prostate;Publishing;rare variant;Research;Research Support;Resources;response;Sampling;Scanning;Scientist;screening;Specimen;Statistical Methods;Support Groups;Surveys;Techniques;Technology;tissue processing;Tissues;tumor;Work

PROJECT_TITLE: DCEG- Genotyping for epidemiology studies


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS

PROJECT_TERMS: Biological;cold temperature;Collection;computerized;Contracts;Development;Division of Cancer Epidemiology and Genetics;Epidemiology;epidemiology study;Equipment;Equipment and supply inventories;Human;Maintenance;Molecular Epidemiology;preservation;Procedures;programs;repository;Sampling;Services;Specimen;Transportation

PROJECT_TITLE: DCEG- Repository Services for epidemiology studies


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics

PROJECT_TERMS: anti-cancer research;biobank;Biological;Biological Assay;Biological Process;bioprocess;blood fractionation;Blood specimen;cancer epidemiology;cell immortalization;Cell Line;Cells;Cervical;CLIA certified;Clinical;cold temperature;Contracts;Cryopreservation;Cryopreserved Cell;Cytology;Detection;Diagnostics Research;Division of Cancer Epidemiology and Genetics;DNA;Electronics;Epidemiology;epidemiology study;Erythrocytes;established cell line;Feces;Fibroblasts;Flow Cytometry;Fluorescence-Activated Cell Sorting;Freeze Drying;Freezing;Hormones;Human;Human Herpesvirus 4;Immunologic Monitoring;Immunologic Tests;Immunologics;In Vitro;Infrastructure;instrumentation;Laboratories;Liquid substance;Malignant neoplasm of cervix uteri;Mass Spectrum Analysis;Measurement;Molecular;molecular diagnostics;Molecular Epidemiology;Mutation Detection;Nitrogen;Nucleic Acids;Paraffin Embedding;Pathogen detection;Pathogenesis;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Polymorphism Analysis;Preparation;Prevention;Process;programs;Proteins;quality assurance;Quality Control;Reporting;repository;Research Personnel;RNA;Scientist;Serum;Services;Single Nucleotide Polymorphism;small molecule;Specimen;Specimen Handling;Spectrophotometry;Structure;Techniques;Technology;Tissue Embedding;Tissues;transforming virus;tumor;Urine;Virus;Whole Blood

PROJECT_TITLE: DCEG- Molecular Assays for epidemiology studies


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Nanotechnology;Natural Products;Precision Medicine

PROJECT_TERMS: Antineoplastic Agents;assay development;biobank;Biological;Biological Assay;Biological Markers;Biological Products;biopharmaceutical industry;Clinic;Clinical;clinical center;Clinical Trials;Collaborations;Contracts;Correlative Study;Cyclic GMP;Data Science;Development;Diagnostic;Diagnostic tests;Discipline of Nursing;Division of Cancer Treatment and Diagnosis;drug development;drug discovery;Drug Kinetics;drug production;Evaluation;Funding;Genomics;high throughput screening;Image;In Vitro;in vivo;Informatics;Information Systems;Laboratories;Libraries;Malignant Neoplasms;manufacture;Medical;Molecular;Nanotechnology;Natural Products;New Agents;novel diagnostics;novel therapeutic intervention;patient derived xenograft model;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacology;Pre-Clinical Model;Precision medicine trial;Production;programs;Radiochemistry;Radiopharmaceuticals;repository;Research;Services;Technology;Testing;Therapeutic Intervention;Toxicology;Translational Research;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Division of Cancer Treatment and Diagnosis- Operational Task Order


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute Promyelocytic Leukemia;Agonist;Anaphase;Aneuploidy;antagonist;Antineoplastic Agents;Biological Assay;Chimeric Proteins;combat;companion diagnostics;Differentiation Therapy;Etiology;FDA approved;Genetic;Immunotherapy;Laboratories;Malignant Neoplasms;Molecular;Normal Cell;Pathway interactions;Pharmacology;Play;Retinoic Acid Receptor;retinoic acid receptor alpha;Retinoids;RXR;Signal Transduction;targeted cancer therapy;tool;ubiquitin isopeptidase

PROJECT_TITLE: Molecular Pharmacology Lab


NIH_SPENDING_CATS: Cancer;Clinical Research

PROJECT_TITLE: Strategic Scientific Pilot Support


PROJECT_TERMS: Address;anti-cancer research;Cryoelectron Microscopy;Data Collection;Goals;Image;interest;Laboratories;Macromolecular Complexes;Malignant Neoplasms;Microscope;National Cancer Institute;Resolution;Structural Biologist;United States National Institutes of Health

PROJECT_TITLE: Cryo-EM


PROJECT_TERMS: anti-cancer research;Capital;Core Facility;Development;Equipment;Expenditure;Funding;Gene Mutation;Institution;Intramural Research Program;Laboratories;Laboratory Research;Malignant Neoplasms;Modeling;programs;RAS genes;Research;research and development;Research Personnel;Signal Transduction;Technology;Therapeutic;United States Dept. of Health and Human Services

PROJECT_TITLE: RAS Program at FNL


PROJECT_TERMS: base;Clinical;clinical center;Computers;Contractor;Contracts;Development;Funding;improved;Libraries;Maryland;National Cancer Institute;Office of Administrative Management;operation;programs;repaired;research and development;Research Personnel;Services;statistical service;United States National Institutes of Health

PROJECT_TITLE: NCI-F Operations and Technical Support II


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research

PROJECT_TITLE: Informatics Support at FNLCR


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: anti-cancer research;cancer genomics;Clinical Data;Collection;Communities;data repository;Data Set;data sharing;effective therapy;follow-up;Genomic approach;Genomic Data Commons;Malignant Childhood Neoplasm;Molecular;precision medicine;Research;Therapeutic;treatment program;Update

PROJECT_TITLE: GDC Clinical Data Update


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

PROJECT_TERMS: Blood;Breast Cancer Prevention Trial;Clinical Trials;cost;Leukocytes;Maintenance;National Surgical Adjuvant Breast and Bowel Project;Plasma;repository;Specimen;Study of Tamoxifen and Raloxifene;Woman;Women's study

PROJECT_TITLE: DCP - COPTRG Support [National Surgical Adjuvant Breast and Bowel Project (NSABP)


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

PROJECT_TERMS: biomarker validation;Clinical;Clinical Research;Early Detection Research Network;Funding;Histologic;interest;Prevention;repository;Screening for cancer;Specimen;Tissues;Vial device

PROJECT_TITLE: DCP - Early Detection Research Network (EDRN) Repository


PROJECT_TERMS: Area;clinical development;Contractor;Development;Development Plans;human biological material;Knowledge;Laboratories;manufacturing capabilities;Marketing;Monitor;operation;Performance;Phase;pre-clinical;Procedures;Process;product development;programs;Protocols documentation;public-private partnership;quality assurance;Quality Control;research clinical testing;Site;skills;Specimen;Therapeutic;Vaccines

PROJECT_TITLE: DCP - COPTRG - SELECT/PCPT


PROJECT_TITLE: DCP- Cancer Immunoprevention Laboratory Support


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

PROJECT_TERMS: biobank;Biological Specimen Banks;cancer prevention;clinical research site;Contracts;Phase;prevention clinical trial;programs

PROJECT_TITLE: DCP - Cancer Prevention Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia) BioRepository


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science

PROJECT_TITLE: DCP - Clin Trl Info Mgt -DCP Enterprise System Knowledge Base (DESK)


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Budgets;Computers;Contract Services;Contractor;Contracts;data management;Development;Diagnosis;Funding;Head;Health;HIV Infections;HIV/AIDS;Human Herpesvirus 8;improved;In Vitro;in vivo;International;Laboratory Animal Science;Libraries;Maintenance;Malignant Neoplasms;Modeling;Molecular Virology;multidisciplinary;nonhuman primate;Office of Administrative Management;operation;Prevention;Principal Investigator;programs;repaired;repository;Research;research and development;Safety;Satellite Viruses;Services;statistical service;Technology;tumor;Viral Epidemiology;Virus;Work

PROJECT_TITLE: AIDS and Cancer Virus Program (ACVP)


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: base;Clinical;clinical center;Computers;Contract Services;Contractor;Contracts;data management;Development;Funding;improved;Information Services;International;Libraries;Maryland;National Cancer Institute;Office of Administrative Management;operation;programs;repaired;Research Personnel;Science;Services;statistical service;Support Contracts;United States National Institutes of Health

PROJECT_TITLE: NCI-Frederick Operational Support


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: Area;Biological Products;Cell Culture Techniques;Cell Therapy;Clinical;Clinical Trials;Contractor;Development;Good Manufacturing Process;Guidelines;Immunoconjugates;Industry;Investigational Drugs;manufacture;Mission;Monoclonal Antibodies;Peptides;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase III Clinical Trials;plasmid DNA;Program Development;Recombinant Proteins;Regulation;Research Personnel;Sterility;Testing;United States Food and Drug Administration;vector vaccine;Vial device;Virus;Work

PROJECT_TITLE: DCP - Biopharmaceutical Development Program (BDP) Support


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

PROJECT_TERMS: Area;Caribbean region;clinical development;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Contractor;Contracts;Development;Development Plans;experience;HIV;human biological material;Human Papilloma Virus-Related Malignant Neoplasm;Knowledge;Laboratories;Latin American;manufacturing capabilities;Marketing;Monitor;Nursing Research;operation;Performance;Phase;pre-clinical;prevention clinical trial;Procedures;Process;product development;programs;Protocols documentation;public-private partnership;quality assurance;Quality Control;Regulatory Affairs;research clinical testing;Site;skills;Specialist;Specimen;Therapeutic;Vaccines

PROJECT_TITLE: DCP - Clinical Trials Regulatory & Monitoring Support for US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network


PROJECT_TERMS: Address;Advocate;American;anti-cancer research;Cancer Control;Cessation of life;Congresses;Consultations;Contractor;Country;Data;Data Analyses;Data Reporting;data visualization;Documentation;experience;Extramural Activities;global health;Goals;Grant;Individual;international partnership;Knowledge;Leadership;low and middle-income countries;Malignant Neoplasms;meetings;Mission;Oncology;Play;Publications;Reporting;Research;Research Personnel;Resources;Scientist;Site;technical writing;Training;Training Activity;Travel;web site;Work;Writing

PROJECT_TITLE: CGH - Center for Global Health Data Analysis, Technical Support and Dialogues


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

PROJECT_TERMS: Academia;anti-cancer research;biopharmaceutical industry;Cancer Center;cancer genomics;Cancer Model;Catalogs;Clinical;clinical diagnostics;Communities;Data;data modeling;Data Sources;Foundations;Genomic Data Commons;Genomics;Goals;Human;In Vitro;Institution;Intellectual Property;interest;International;Libraries;Malignant Neoplasms;member;Methods;model development;Modeling;Molecular;National Cancer Institute;next generation;novel;Office of Cancer Genomics;Online Systems;Organoids;query tools;Research Personnel;Resources;response;Source;System;Technology;Tissue Donors;Trust

PROJECT_TITLE: HCMI Searchable Catalog


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Biodistribution;Biological Assay;Biomedical Computing;Biomedical Research;Canis familiaris;Cells;Clinical;Clinical Trials;comparative;Computational Science;coronavirus pandemic;COVID-19;Data Analyses;data integration;data resource;Development;Drug Kinetics;efficacy study;Electron Microscopy;Gene Expression;Image;Laboratory Animals;manufacture;Methods;novel coronavirus;Oncology;Pharmaceutical Preparations;pre-clinical;Proteomics;Public Health;Rare Diseases;screening;Serology test;Services;Standardization;therapeutic development;Translational Research;Validation

PROJECT_TITLE: THE COVID 19 SERVICES CATALYZE TRANSLATIONAL RESEARCH FINDINGS INTO PUBLIC HEALTH CHANGES TO ADDRESS THE NOVEL CORONAVIRUS PANDEMIC THROUGH IMPLEMENTATION OF STANDARDIZED SEROLOGY TESTING FOR ITS INTE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: GAITHERSBURG

PI_NAMEs: BALACHANDRAN, DESMA  (contact)

PROJECT_TERMS: Adverse event;Cancer Therapy Evaluation Program;Contracts;Databases;Division of Cancer Treatment and Diagnosis;Electronic Mail;Lead;Letters;meetings;National Cancer Institute;operation;Outcome;Process;Protocols documentation;Reporting;symposium;timeline;working group

PROJECT_TITLE: OPERATION & SUPPORT OF THE CTEP PROTOCOL AND INFORMATION OFFICE (PIO)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Pediatric;Women's Health Research

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

PI_NAMEs: BURCH, DAVID  (contact)

PROJECT_TERMS: Area;autism spectrum disorder;Categories;Client;Data;Decision Making;Disease;Epidemiology;Evaluation;Fetal Growth;Information Management;interest;Knowledge;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Methodology;Problem Formulations;Process;Puberty;Research;screening;systematic review;text searching;Toxicology

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Support for Scoping & Systematic Review Activities of Disease States


NIH_SPENDING_CATS: Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Carcinogens;Complex;Controlled Vocabulary;Data Set;design;Development;Environmental Health;Evaluation;Information Management;Link;Literature;method development;Methods;novel;Process;Publication Bias;Reporting;Research Design;research study;systematic review;Text;tool;tool development;Variant;Vocabulary

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Novel Tools for SIM/Literature-based Evaluations


NIH_SPENDING_CATS: Complementary and Integrative Health

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Support for External Peer Review


PROJECT_TITLE: Scientific Information Management and Literature-based Evaluations for the DTT - Support for Scientific Meetings and Publication


PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Support for Scoping & Systematic Review Activities on Specific Test Agents


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions

PROJECT_TERMS: Adverse effects;Carcinogens;Congresses;Data;Data Analyses;Epidemiology;Evaluation;exposed human population;hazard;Health;Human;Information Management;Literature;Malignant Neoplasms;Monograph;Persons;Publishing;Reporting;Review Literature;screening;systematic review;Toxicology;United States;wood smoke

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Systematic Review of Woodsmoke


NIH_SPENDING_CATS: Cancer;Endocrine Disruptors

PROJECT_TERMS: Adverse effects;Aromatic Polycyclic Hydrocarbons;Carcinogens;Congresses;Data;Data Analyses;Epidemiology;Evaluation;exposed human population;hazard;Health;Human;Information Management;Literature;Malignant Neoplasms;Monograph;Persons;Publishing;Reporting;Review Literature;screening;systematic review;Toxicology;United States

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Systematic Review of PAHs & Nitro PAHs


PROJECT_TERMS: benzotriazole;Cimicifuga racemosa;Complex;Contracts;Data;Evaluation;Information Management;Laboratories;Literature;National Institute of Environmental Health Sciences;Nicotine;Preparation;Publications;Reporting;Stachybotrys;technical report;Toxic effect;Toxicology;Triclosan

PROJECT_TITLE: Scientific Information Management and Literature-Based Evaluations for the DTT - Support for Report Preparation


PROJECT_TERMS: Area;Cardiovascular Diseases;Cardiovascular system;Categories;Client;Data;Decision Making;Disease;Evaluation;Hypertension;Information Management;interest;Knowledge;Literature;Maps;Methodology;pregnancy disorder;Problem Formulations;Process;Research;screening;systematic review;text searching;Toxic effect;Toxicology

PROJECT_TITLE: Scientific Information Management and Literature-based Evaluations for the DTT - Support for Scoping Activities of Cardiovascular Toxicity and Disease


ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: VALMONTE, CLAUDIA  (contact)

PROJECT_TERMS: Advisory Committees;cancer therapy;Cancer Therapy Evaluation Program;clinical center;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Collaborations;Contractor;Contracts;Data Analyses;Division of Cancer Treatment and Diagnosis;Evaluation;Extramural Activities;Grant;Group Meetings;Information Management;Investigational Therapies;meetings;molecular oncology;National Cancer Advisory Board;National Clinical Trials Network;programs;Recommendation;Research Personnel;trial planning;U-Series Cooperative Agreements;working group

PROJECT_TITLE: CLINICAL TRIALS AND INFORMATION MANAGEMENT SUPPORT


PROJECT_TERMS: Advisory Committees;cancer therapy;Cancer Therapy Evaluation Program;clinical center;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Collaborations;Contractor;Contracts;Data Analyses;Division of Cancer Treatment and Diagnosis;Evaluation;Extramural Activities;Funding;Grant;Group Meetings;Information Management;Investigational Therapies;meetings;molecular oncology;National Cancer Advisory Board;National Clinical Trials Network;programs;Recommendation;Research Personnel;trial planning;U-Series Cooperative Agreements;working group

PROJECT_TITLE: CLINICAL TRIALS AND INFORMATION MANAGEMENT SUPPORT-Moonshot Funding


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

PI_NAMEs: WILLIAMS, MELANIE  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: Rockville

ORG_NAME: DIGITAL INFUZION, INC.

PI_NAMEs: BOUR, STEPHAN  (contact)

PROJECT_TERMS: Clinical;Collaborations;Communication;data dissemination;data management;design;influenza virus vaccine;innovation;manufacture;outreach;programs;statistical center;Toxicology;Training;Vaccines

PROJECT_TITLE: Collaborative Influenza Vaccine Innovation Centers STATISTICAL, DATA MANAGEMENT AND COORDINATION CENTER (SDMCC)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Contemporary literature for the care of late preterm infants during the birth hospitalization is limited, and no current clinical benchmarks or quality measures exist for this population of 280,000 infants born per year in the United States. Significant variation exists in their clinical management, including inter-institutional variability in admission rates that has not been explained by clinical illness severity; this suggests overutilization of costly NICU care, which may lead to unnecessary separation of the mother-infant dyad. The proposed research establishes a rigorous understanding of the clinical needs of these infants, tests the association of structural variables to late preterm infant outcomes, and establishes both clinical benchmarks and quality markers for their care during the birth hospitalization.

PI_NAMEs: JOSHI, NEHA SHIRISH (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Address;Admission activity;Advocate;Antibiotics;Area;Award;Benchmarking;Birth;Breast Feeding;California;care delivery;care outcomes;career;Career Choice;career development;Caring;Childhood;Clinical;clinical care;Clinical Data;clinical epidemiology;Clinical Management;clinical practice;Clinical Research;cohort;Complement;cost;Data Linkages;Data Set;Databases;Delphi Study;design;Development;Disparity;Effectiveness;effectiveness/implementation trial;Environment;Ethnic Origin;Exclusion;Financial cost;Friends;Gel;Gestational Age;Glucose;Goals;Grant;health care availability;health care delivery;health economics;Health Services;Health Services Research;Hospitalists;Hospitalization;Hospitals;Hypoglycemia;implementation efforts;implementation science;improved;Incidence;Incubators;Infant;Infant Care;infant outcome;Institution;Institutional Policy;inter-institutional;Intervention;Knowledge;Lead;Leadership;Length of Stay;Literature;Location;Measurement;Measures;Medical;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;Modification;Morbidity - disease rate;Mothers;multidisciplinary;natural hypothermia;Neonatal;Neonatal Intensive Care Units;Newborn Infant;Nurses;Outcome;Outcome Measure;Outcomes Research;Parents;Patients;Pediatric Hospitals;Perinatal;perinatal outcomes;Phototherapy;Physicians;Physiologic Thermoregulation;Population;Population Study;Positioning Attribute;Pregnancy;premature;Premature Infant;Process;Process Measure;Quality Indicator;Quality of Care;Race;Recommendation;Records;Research;Research Personnel;Retrospective cohort study;Risk;Risk Adjustment;Role;Scholarship;Scientist;Severity of illness;Site;skills;Socioeconomic Status;structural determinants;Structure;Testing;Training;United States;Universities;uptake;Variant;Very Low Birth Weight Infant;World Health Organization;Writing

PROJECT_TITLE: Developing Clinical Benchmarks and Quality Indicators forLate Preterm Infants During the Birth Hospitalization

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cannabinoid Research;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE In our published work, we are the first group to determine that anti-CD4 autoantibodies increase in HIV+ drug- abusers and contribute to altered HIV reservoir and poor CD4+ T cell recovery from suppressive ART by inducing CD4+ T cell death via antibody-mediated cytotoxicity (ADCC). However, how drug-induced inflammation facilitates the development of anti-CD4 autoantibodies and the mechanisms of HIV pathogenesis modulation by anti-CD4 antibodies remain poorly understood. In this proposal, we will isolate monoclonal anti-CD4 antibodies and elucidate the molecular and cellular bases of autoimmunity-mediated poor immune recovery observed in ART-treated HIV+ drug abusers, which will provide information on therapeutic strategies to prevent autoimmunity in HIV pathogenesis.

PI_NAMEs: JIANG, WEI  (contact);SHENG, ZIZHANG

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;Affinity;Antibodies;antibody-dependent cell cytotoxicity;Antiinflammatory Effect;antiretroviral therapy;Area;Autoantibodies;Autoimmunity;B-Lymphocytes;base;Binding;Bioinformatics;Cannabis;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Death;Cell Physiology;Cells;Chronic;Cocaine;cocaine use;Cocaine Users;comorbidity;comparison control;Complex;Cryoelectron Microscopy;CXCL10 gene;CXCR3 gene;Development;Drug abuse;drug abuser;Drug usage;Drug user;Epitopes;Exhibits;Fibrosis;Genetic;HIV;HIV Envelope Protein gp120;HIV Infections;Human;human monoclonal antibodies;IL8 gene;Immune;immune activation;immune reconstitution;Immune response;Immunoglobulin G;improved;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;inhibitor;Intestinal permeability;Knowledge;Leukocytes;Link;Lymphatic;marijuana smoker;marijuana use;marijuana user;Measures;Mediating;memory CD4 T lymphocyte;microbial;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;neuroinflammation;non-drug;pathogen;Pathogenesis;Pathogenicity;Pathology;Patients;Peripheral;Persons;Pharmaceutical Preparations;Plasma;Play;polyclonal antibody;Population;prevent;Production;Public Health;Publishing;Recovery;recruit;response;Signal Pathway;South Carolina;Specificity;Substance Use Disorder;Surface Plasmon Resonance;Systemic Lupus Erythematosus;T-Cell Depletion;T-Lymphocyte Subsets;Therapeutic;therapeutic development;Thymus Gland;transcriptome;Viral;Work;X-Ray Crystallography

PROJECT_TITLE: Impacts of drug abuse-mediated inflammatory perturbations on affinity maturation of anti-CD4 autoantibodies and poor immune reconstitution from ART in HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The Project Narrative has been addressed in the Overall Component per the RFA

PI_NAMEs: PIANTADOSI, STEVEN  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Address;Adolescent and young adult cancer patients;American College of Surgeons Oncology Group;Cancer and Leukemia Group B;Clinical;Clinical Research;Clinical Trials;Community Clinical Oncology Program;design;Education;Effectiveness;Enrollment;Ensure;Fostering;Goals;Healthcare Systems;Infrastructure;Institution;Lead;Leadership;Malignant Neoplasms;member;North Central Cancer Treatment Group;older patient;Oncology;operation;patient population;Patients;Policies;Principal Investigator;programs;rare cancer;recruit;Research;Research Personnel;Research Priority;Services;Site;Surgeon;translational cancer research;Translational Research;translational scientist;U-Series Cooperative Agreements;Work

PROJECT_TITLE: Member Site Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Precision Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION

ORG_STATE: PA

PI_NAMEs: ODWYER, PETER J (contact)

PROJECT_TERMS: Acceleration;Adult;American College of Radiology Imaging Network;anti-cancer research;biobank;Biological;Biological Markers;Biometry;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;care outcomes;Center for Translational Science Activities;Clinical Markers;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Community Clinical Oncology Program;Community Practice;Complex;Conduct Clinical Trials;Dana-Farber Cancer Institute;Data;Data Analyses;Data Coordinating Center;Databases;Development;Disease;Eastern Cooperative Oncology Group;Environment;Funding;Generations;Goals;Image;imaging study;Immunologics;improved;improved outcome;Infrastructure;innovation;Investigational Therapies;Laboratories;Lead;Malignant Neoplasms;Mentorship;Modeling;next generation;novel;operation;Participant;Patients;Population;Positioning Attribute;Prevalence;Procedures;programs;Protocols documentation;quantitative imaging;Reporting;Research;Research Personnel;Resources;Science;scientific organization;Site;Specialized Program of Research Excellence;Structure;System;Translating;treatment effect;Universities

PROJECT_TITLE: Clinical Trials Development Core


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: RELEVANCE (See instructions): The RCSB Protein Data Bank (PDB) supports open access to an enormous wealth of three-dimensional biomolecular structure information in the PDB archive, provided in the context of biological function, biochemical pathways, cellular processes, disease states, and molecular evolution at RCSB.org. PDB data and RCSB PDB Services expand fundamental scientific knowledge and contribute to improvements in human health and treatment of disease.

PI_NAMEs: BURLEY, STEPHEN K (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Agreement;Amino Acid Sequence;Applied Research;archive data;Archives;Artificial Intelligence;Basic Science;beamline;Biochemical Pathway;Bioinformatics;Biological;Biological Process;Biological Sciences;Biology;Biotechnology;Blood Circulation;Carboxypeptidase A;Catalysis;Cell Physiology;Cells;Charge;chemical reaction;collaboratory;Communities;Complement;Complex;COVID-19 vaccine;Cryo-electron tomography;Cryoelectron Microscopy;Crystallography;cyber infrastructure;Data;Data Analyses;data archive;Data Collection;data exploration;data preservation;data quality;data repository;Department of Energy;Deposition;design;Development;Disease;DNA;Education;Ensure;Enzymes;FDA Emergency Use Authorization;Foundations;Funding;Genetic Materials;graduate student;Growth;Health;Hemoglobin;Human;Hybrids;improved;Individual;innovation;insight;Instruction;instrumentation;interest;Investments;Knowledge;Ligands;Link;macromolecular assembly;Metadata;Methodology;Methods;Modeling;Modems;Modernization;Molecular Conformation;Molecular Evolution;Muramidase;Myoglobin;Nucleic Acids;operation;Organism;Oxygen;Paper;Paxlovid;Positioning Attribute;Postdoctoral Fellow;preservation;protein data bank;protein structure;protein structure prediction;Proteins;prototype;Publications;remediation;Reporting;Research;Research Institute;Research Personnel;Rest;Ribonucleases;RNA vaccine;Science;Services;small molecule;Software Tools;Structural Biologist;structural biology;Structural Protein;Structure;Synchrotrons;three dimensional structure;tool;Training;United States;United States National Institutes of Health;Universities;Validation;Viral;Virus;Visualization;web portal;Work;x-ray free-electron laser

PROJECT_TITLE: PDB Management by the Research Collaboratory for Structural Bioinformatics

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-X (NS)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Narrative Blood flow to the brain is reduced in vascular dementia and mixed forms of Alzheimer’s disease, but it is unknown how or why this happens. Our recent work suggests that white blood cells interact with the smallest blood vessels, the capillaries, contributing to reduced blood flow and cognitive impairment. The proposed project examines mouse models of vascular dementia and Alzheimer’s disease over time to investigate why and how white blood cells contribute to vascular damage, will closely examine molecular changes in white blood cells driving blood flow reductions and inflammation, and is expected to lead to an understanding of how the brain communicates with the periphery, driving neurodegenerative diseases.

PI_NAMEs: BRACKO, OLIVER  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Acute;Aerobic;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid pathology;anaerobic glycolysis;Anatomy;Automobile Driving;Behavior;Biological Markers;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;blood-based biomarker;blood-brain barrier permeabilization;Brain;cardiovascular risk factor;Cell Communication;Cell Surface Proteins;Cells;Cerebrovascular Circulation;chronic inflammatory disease;Cognition;Communication;Disease;disease model;Disease Progression;endothelial dysfunction;Etiology;Functional disorder;glycosylation;Hemorrhage;Heterogeneity;hypoperfusion;Immune;Impaired cognition;Impairment;in vivo two-photon imaging;Inflammation;Inflammatory;Inflammatory Response;Investigation;Ischemic Stroke;Knowledge;Lead;Leukocytes;Longitudinal Studies;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Microvascular Dysfunction;Modeling;Molecular;mouse model;Nerve Crush;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron regeneration;Neurons;neurovascular unit;neutrophil;Neutrophil Activation;Obstruction;Pathology;Patients;Pattern;Pericytes;Physiological;Population;Regulation;Research;Role;Signal Transduction;single cell sequencing;specific biomarkers;Stroke;tau Proteins;Testing;therapeutic target;Time;transcriptome sequencing;Traumatic Brain Injury;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;vascular inflammation;Waste Products;Work

PROJECT_TITLE: Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (55)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Nanotechnology

ORG_CITY: JACKSON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: NARRATIVE Tooth-shaped caps made from durable and aesthetically pleasing ceramic materials, require replacement when they or the tooth underneath are damaged and can’t be restored. The strong adhesive used to keep the cap in place makes removal with a drill uncomfortable for patients. We propose a drill-free method using a new compound that easily unglues the ceramic cap when activated by heat. 1

PI_NAMEs: SALAZAR MAROCHO, SUSANA M (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TITLE: Novel primer for bonding and debonding of high-strength dental ceramics

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The levels of fructose are higher in the brains of patients with Alzheimer’s disease, and diets rich in high- fructose corn syrup are associated with an increased risk of developing Alzheimer’s disease. However, the mechanism by which fructose metabolism may accelerate Alzheimer’s disease onset and progression is unknown. Here, we show that fructose transport and breakdown occurs mainly in the immune cells of the brain (microglia) and propose that limiting fructose metabolism may be a novel approach to improve the function of these critical cells and halt the development of Alzheimer's, even in the early stages of the disease.

PI_NAMEs: BRUCE, KIMBERLEY D (contact);LANASPA GARCIA, MIGUEL ANGEL

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Acceleration;Age Months;age related;age related changes;aged;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's neuropathogenesis;Automobile Driving;Behavioral;Bioinformatics;Brain;brain cell;Brain region;Cardiometabolic Disease;Cell Respiration;Cells;Chronic;Consumption;Data;Development;Diet;dietary;dietary control;Disease;Disease Progression;Disease susceptibility;Enzymes;Family;Fructose;Functional disorder;functional improvement;Future;Genes;Genetic;genetic approach;Glucose;Glycolysis;Goals;Histologic;Human;Immune;improved;In Vitro;in vivo;inhibitor;interest;Intervention;Ketohexokinase;Knock-out;Knockout Mice;Late Onset Alzheimer Disease;Link;Lipids;LoxP-flanked allele;Mediating;member;Metabolic;Metabolism;metabolomics;Microglia;Molecular Target;monocyte;Morphology;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;novel;novel strategies;Onset of illness;Oxidative Phosphorylation;peripheral blood;pharmacologic;Phenotype;Phosphotransferases;Positioning Attribute;prevent;Process;Proteins;Reporting;Research Personnel;Risk;Role;solute;Testing;Time;tool;Transcript;transcriptomics;Transgenic Mice

PROJECT_TITLE: Does GLUT5-mediated Fructose Metabolism drive Microglial Dysfunction in Aging and Alzheimer's Disease?


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Obesity;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Substance Misuse

PHR: Narrative Buprenorphine, the gold-standard treatment for opioid use disorder (OUD), reduces overdose mortality, but too many individuals prematurely discontinue treatment due to emergence of opioid craving, leading to relapse and other adverse outcomes. Recent preclinical work suggests that glucagon-like peptide 1 (GLP-1) agonists reduce the hedonic value of substances of misuse and attenuate opioid seeking, raising the possibility that these FDA- approved medications may be repurposed, allowing for a high probability of technical success which will shorten the development timeline for use in OUD treatment. This pilot randomized trial will determine whether weekly injections of semaglutide can attenuate cue-reactivity in individuals with OUD newly initiating buprenorphine, and explore the safety and preliminary efficacy of semaglutide as an adjunct to buprenorphine during OUD treatment.

PI_NAMEs: SUZUKI, JOJI  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Adherence;Adverse effects;Adverse event;adverse outcome;Agonist;Alcohol consumption;alcohol use disorder;Animals;attentional bias;Attenuated;attenuation;Blood Glucose;Body mass index;Brain;Buprenorphine;buprenorphine treatment;Clinical Research;Cocaine;Cocaine use disorder;Confusion;craving;cue reactivity;Cues;Data;Decision Making;design;Development;Diabetes Mellitus;discount;Double-Blind Method;Early treatment;effective therapy;efficacy trial;Enrollment;Epidemic;evidence base;exenatide;Exhibits;FDA approved;Fentanyl;Food;Formulation;gastrointestinal;Gastroparesis;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glycosylated hemoglobin A;Goals;hedonic;Human;illicit opioid;improved;Individual;Ingestion;Injections;innovation;Insulin;Intervention;liraglutide;medication for opioid use disorder;Monitor;Moods;mortality;National Institute of Drug Abuse;Nicotine;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity treatment;Opioid;opioid epidemic;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Oral Administration;Outcome;Overdose reduction;Overdose reversal;overdose risk;Pancreas;Participant;Patient Self-Report;Pharmaceutical Preparations;Pharmacotherapy;Placebos;pre-clinical;preclinical study;premature;prevent;primary outcome;Probability;Public Health;Quality of life;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;reduced food intake;reduced substance use;Relapse;relapse prevention;Research;Rewards;Risk;risk minimization;Risk Reduction;Safety;safety outcomes;safety study;secondary outcome;Small Intestines;standard care;Stimulus;Subcutaneous Injections;Sublingual drug administration;substance misuse;substance use;success;suicidal;Therapeutic Agents;timeline;Tobacco Use Disorder;Toxicology;treatment strategy;Urine;Visit;Visual;week trial;Weight;Work

PROJECT_TITLE: Semaglutide for the treatment of opioid use disorder: A pilot randomized controlled trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Sleep Research;Women's Health Research

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Hormone sensitivity (neural sensitivity to normal fluctuations in ovarian steroids across the menstrual cycle) may contribute to sex differences in depression and sleep problems that emerge after puberty, but very little is known about hormone sensitivity in adolescents. The proposed study will characterize hormone sensitivity in adolescent females with depression and provide foundational data for future work investigating the developmental influence of hormone sensitivity on the development of sex differences in depression and sleep problems that emerge after menarche. This line of work has significant implications for early identification efforts and pharmacological and psychosocial interventions for adolescent females.

PI_NAMEs: STUMPER, ALLISON  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: actigraphy;Address;Adolescent;Adult;Adult women;aged;Anxiety;Area;Biological;child depression;Clinical Research;clinically significant;Code;Competence;Data;depressive symptoms;Development;Diagnostic;Dryness;Early identification;Enrollment;Estrogens;experience;falls;Female;Female Adolescents;Funding;Future;Goals;hormone sensitivity;Hormones;Infrastructure;Institution;Intervention;K-Series Research Career Programs;Knowledge;Length;life span;longitudinal, prospective study;Luteal Phase;male;Measurement;Menarche;Menstrual cycle;Menstruation;Mental Depression;Mentors;Mentorship;Methods;Modeling;Mood Disorders;mood symptom;Moods;multilevel analysis;network models;neural;neurobehavioral;novel;Ovarian;Ovarian Steroid Hormone;Participant;Patient Self-Report;Perimenopause;perimenstrual;Persons;pharmacologic;Phase;Prevention;Progesterone;programs;psychosocial;Puberty;puberty transition;Recording of previous events;Reporting;reproductive;Research;Research Personnel;Resources;response;Risk;Role;Sampling;sex;sex development disorder;Sex Differences;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;Standardization;Steroids;suicidal;Symptoms;System;Time;Training;United States National Institutes of Health;Universities;Urine;Withdrawal;women versus men;Work

PROJECT_TITLE: Ovarian Steroid Effects on Mood and Sleep Across the Adolescent Menstrual Cycle

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Immunotherapy

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE Immune tolerance is vital in preventing immune dysregulation and autoimmunity. This proposal is a supplement to R01 AI156534, “The role of IL-37 in human regulatory T cells,” designed to enhance the training of Dr. Cameron Lloyd, PhD, who will be hired as a postdoctoral fellow in the Department of Dermatology at the University of Colorado, Anschutz Medical Campus.

PI_NAMEs: FUJITA, MAYUMI  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Anti-Inflammatory Agents;Antigens;Applications Grants;Autoimmunity;Binding;Biology;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;Clinical;Clinical Medicine;Colorado;cytokine;Dendritic Cells;Dermatology;design;disadvantaged background;Discipline;Doctor of Philosophy;extracellular;Failure;Family member;Fellowship;forkhead protein;Foundations;FOXP3 gene;Funding;Genetic Transcription;Graft Rejection;Health;Heterogeneity;Homeostasis;Human;human disease;Immune;Immune system;Immune Tolerance;Immunologist;Immunology;Immunosuppression;In Vitro;in vivo;Individual;Inflammatory;Interleukin-1;Investigation;MADH3 gene;Maintenance;Mediating;Medical;member;Mentors;Microbiology;Molecular;Molecular Biology;Mus;parent grant;parent project;Pathology;Patient Care;peripheral tolerance;pharmacologic;Postdoctoral Fellow;prevent;Protein Chemistry;Regulatory T-Lymphocyte;Research;Role;T-Lymphocyte;T-Lymphocyte Subsets;Texas;Therapeutic;Therapeutic Uses;therapeutically effective;tissue injury;tool;Training;transcription factor;Transcriptional Regulation;transgene expression;Transgenic Mice;Transgenic Organisms;Translating;translational impact;Translational Regulation;Transplantation;Tumor Immunity;Universities;Work

PROJECT_TITLE: The role of IL-37 in human regulatory T cells, Supplement

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Recovery Support Services;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative This career development grant will provide Dr. McCool with training in mindfulness-based interventions, psychophysiological self-regulation measurement through heart rate variability, advanced quantitative methods, the use of wearable sensors and other advanced mobile health applications, and professional development. Using wearable sensors, the proposed research examines the changes in heart rate variability over the course of an 8-week mindfulness-based intervention and assesses the relationship between heart rate variability and the addiction cycle domains of negative affect, craving, executive function, and drinking in daily life using ecological momentary assessment. The well-integrated research and training plans developed with an excellent mentorship team will support Dr. McCool’s independent research program focused on improving and developing psychological treatments for alcohol use disorder.

PI_NAMEs: MCCOOL, MATISON WILLIAM (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: adaptive intervention;addiction;Address;Affect;Aftercare;Age;aged;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol intervention;alcohol response;alcohol use disorder;Alcohols;Applications Grants;Area;Back;Basic Science;Brain region;Cardiac;career;career development;Cessation of life;cognitive load;cost;Country;Coupled;craving;cue reactivity;Data;Data Collection;Development;drinking;Ecological momentary assessment;Economics;Effectiveness;Emotions;Enrollment;Equation;Evidence based treatment;executive function;experience;follow-up;Goals;Grant;Growth;Health Technology;Heart;heart rate variability;Heavy Drinking;Human;improved;improved outcome;indexing;Individual;individual variation;Informal Social Control;innovation;Knowledge;Life;Literature;Measurement;Measures;Mentors;Mentorship;Methods;mHealth;mindfulness;mindfulness intervention;Mobile Health Application;Modeling;National Institute on Alcohol Abuse and Alcoholism;negative affect;New Brunswick;New Mexico;Occupations;Outcome;Parasympathetic Nervous System;Participant;patient oriented research;Patient Recruitments;Persons;Phase;Process;programs;Protocols documentation;psychologic;Psychophysiology;Public Health;randomized trial;Reaction;Recommendation;Recovery;relapse prevention;Reporting;Research;Research Personnel;research study;response;responsible research conduct;Rest;Science;Scientist;sensor;Severities;sex;skills;Strategic Planning;stressor;substance use;Symptoms;Technology;Testing;Time;Training;treatment as usual;treatment comparison;treatment group;treatment program;Universities;Vagus nerve structure;Visit;wearable sensor technology;Withdrawal

PROJECT_TITLE: Mindfulness-Based Relapse Prevention and Psychophysiological Self-Regulation

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide;Suicide Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This K24 midcareer award will provide the PI with protected time to mentor trainees and to develop new skills with national language processing to identify life stress in social media data, as part of his work elucidating the nature and types of life stressors more relevant to proximal risk for suicidal thoughts and behaviors in adolescents. This award will also provide time for the PI to continue enhancing his mentorship and leadership skills to further his career goals and those of mentees. The importance of this application lies in the need to understand short-term risk for suicidal thoughts and behaviors so as to inform the development of suicide prediction and prevention strategies, as well as the need to train the next generation of patient-oriented researchers addressing the continuingly growing public health concern of youth suicide.

PI_NAMEs: LIU, RICHARD T (contact)

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;Adolescent Psychiatry;Algorithms;Applications Grants;Award;Behavior;career;career development;Child Psychiatry;Clinical;clinical care;Clinical Psychology;Clinical Research;clinical risk;Code;Congresses;Data;Data Pooling;Dedications;Development;early-career faculty;Ecological momentary assessment;Educational workshop;Ethics;Evaluation;experience;Feeling suicidal;Fellowship;Foundations;Funding;Future;General Hospitals;Goals;Grant;Hearing;high risk;High School Student;improved;Internships;Intervention;Jordan;knowledge base;language processing;Leadership;Learning;Life;Life Stress;Manuals;Massachusetts;media use;medical schools;meetings;member;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);mid-career faculty;National Institute of Mental Health;Natural Language Processing;Nature;Neurosciences;next generation;Outcome;Participant;patient oriented;patient oriented research;Population;preadolescence;Prevention strategy;preventive intervention;Process;Productivity;Professional Organizations;programs;Protocols documentation;psychiatric inpatient;Psychologist;Public Health;Publications;recruit;Recurrence;Research;research data dissemination;Research Design;research faculty;Research Personnel;Research Priority;Research Support;Risk;Role;Safety;Series;skills;social media;Strategic Planning;Stress;stressor;suicidal behavior;suicidal risk;Suicide;Surgeon;symposium;System;Talents;Testing;Thinking;Time;Training;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;vulnerable adolescent;Wages;Work;Writing;young adult;Youth

PROJECT_TITLE: Mentoring in Youth Suicide Research

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: Project Narrative / Relevance The circadian clock in the hypothalamic suprachiasmatic nucleus (SCN) of the mammalian brain is a compact neural net- work which can be studied as a simplified model of the entire central nervous system. A major limitation in investigations of neural circuits to-date has been the need to section the brain, destroying most of the network, and divorcing it from its sensory inputs or behavioral outputs. We propose to employ in vivo real-time Ca2+ imaging in the SCN to study cell-type specific rhythmic generation, the network processing of light input that leads to changes in the circadian behavioral rhythm, and how these mechanisms falter during the process of aging.

PI_NAMEs: DAVIDSON, ALEC J (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acute;Affect;Afferent Neurons;Aging;aging process;Anatomy;Behavior;Behavioral;Biological Clocks;Brain;cell type;Cells;Central Nervous System;circadian;circadian behavioral rhythms;circadian biology;circadian pacemaker;Divorce;Eye;fluorescence imaging;functional adaptation;Generations;Goals;Hypothalamic structure;Image;in vivo;Investigation;Learning;Light;Microscope;miniaturize;Modeling;Nervous System;neural;neural circuit;neural network;Neurons;Output;Periodicity;Phenotype;Physiological;Physiology;Population;Process;programs;Property;Research;response;sensory input;Sensory Process;Signal Transduction;Sleep;Specificity;suprachiasmatic nucleus;System;Time;Visualization

PROJECT_TITLE: Visualizing hierarchical processing of photic input to the circadian clock in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: The proposed research is relevant to public health because defects in mitochondrial function and subcellular trafficking along neuronal subcompartments are hallmarks of Alzheimer’s disease (AD). Our proposed research will shed light on AD pathology at the transcriptome, the translatome, and the mitonuclear coordination levels in neurons, which could reveal unappreciated regulatory networks underlying AD. As such, the proposed research is relevant to the part of the NIH’s mission that seeks to develop fundamental knowledge to inform our diagnosis and treatment of human disease.

PI_NAMEs: CHURCHMAN, LEE STIRLING (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Anabolism;Architecture;Area;Bayesian Modeling;Binding;Buffers;Calcium;Cell Fractionation;Cell Nucleus;Cell Physiology;Complex;Cytoplasm;Defect;Diagnosis;Distal;Electron Transport;Equilibrium;excitatory neuron;experimental study;Face;familial Alzheimer disease;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Goals;Grant;human disease;Impairment;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Intervention;Kinetics;Knowledge;Label;Length;Machine Learning;Maps;Membrane;Metabolic;meter;Methods;millimeter;Mission;Mitochondria;Mitochondrial Diseases;Modeling;Mutation;Neurites;Neurodegenerative Disorders;neuronal cell body;Neurons;new therapeutic target;novel;Nuclear;Nuclear Export;Orphan;Outcome;Oxidative Phosphorylation;Pathway interactions;Physiological;Play;polysome profiling;Porosity;Predisposition;presenilin-1;Process;Production;programs;proteostasis;Public Health;Research;Ribosomes;RNA;RNA Transport;RNA-Binding Proteins;Role;Salvelinus;Structure;Synaptic Transmission;Techniques;Therapeutic;Therapeutic Intervention;trafficking;Transcript;transcriptome;Translations;translatome;Tweens;United States National Institutes of Health

PROJECT_TITLE: Subcellular mito-nuclear balance and gene expression dynamics in Alzheimers's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative Diversity of the resident microbiota has been shown to be an important factor in the etiology of T1D, a disease characterized by the autoimmune destruction of insulin-producing beta-cells. I have shown that the microbiota is necessary for establishment of a robust beta-cell mass in vertebrates. The goal of my project is to characterize the signaling mechanisms necessary for microbial regulation of mammalian beta-cell development, which I believe will lead to novel therapeutics for the treatment of diabetes.

PI_NAMEs: HILL, JENNIFER HAMPTON (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Adult;Age;age group;age related;Animal Model;Animals;Antibiotics;Apoptosis;Apoptotic;autoimmune pathogenesis;Autoimmunity;autoreactivity;Bacteria;Beta Cell;Birth;career;Cell Differentiation process;Cells;Child;clinically relevant;Collaborations;combat;commensal microbes;Data Set;design;Development;Developmental Process;Diabetes Mellitus;Diagnosis;Dimensions;Disease;disease model;early childhood;endocrine pancreas development;Ensure;Enterococcus;Environment;Etiology;Exposure to;faculty mentor;Failure;fighting;Future;Gastrointestinal tract structure;Genetic Predisposition to Disease;Germ-Free;Gnotobiotic;Goals;graduate school;gut microbiota;hatching;Health;host microbiota;host-microbe interactions;Human;Immune;Immune system;Immunology;improved;Inbred NOD Mice;Incidence;Infant;innovation;Institution;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intestines;islet;Islets of Langerhans;knowledge base;Lactobacillus;Life;Macrophage;Malignant neoplasm of pancreas;Mammals;Mediating;Metabolic;Metabolism;Metagenomics;Microbe;microbial;microbial colonization;microbial community;microbial host;microbial products;microbial signature;microbiota;Mining;Mission;Mus;Neonatal;neonatal mice;neonate;Newborn Infant;novel strategies;novel therapeutics;Onset of illness;Pancreas;pancreas development;Pancreatic Diseases;Phase;Phenotype;Positioning Attribute;Postdoctoral Fellow;postnatal;Predisposition;prenatal;prevent;Prevention;Process;Production;Proliferating;Regulation;Research;Research Personnel;response;Role;Sampling;Scientist;Severity of illness;Signal Transduction;Source;Stimulus;stool sample;Streptococcus;success;Testing;Therapeutic;Time;Training;Translating;Universities;Utah;Vertebrates;Vision;Work;Zebrafish

PROJECT_TITLE: Mining host-microbe interactions in the neonatal pancreas to combat diabetes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS