NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE – OVERALL UNC CFAR The UNC Center for AIDS Research provides essential infrastructure support for the wide range of HIV related research for its members. This research contributes to the major goals of Ending the HIV Epidemic and HIV prevention and cure, and has overarching public health impact.

PI_NAMEs: ADIMORA, ADAORA A;SWANSTROM, RONALD I (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;AIDS clinical trial group;AIDS prevention;Analytical Chemistry;antiretroviral therapy;Appointment;Area;Award;base;Behavioral;behavioral and social science;Behavioral Sciences;Biological Specimen Banks;Biometry;Brain;China;CLIA certified;Clinical;Clinical Pharmacology;co-infection;cohort;Collaborations;collaboratory;Communicable Diseases;Communication;Communities;community collaboration;comorbidity;Comprehensive Cancer Center;Country;Criminal Justice;Data;Data Analyses;data management;Databases;Development;Disparity;Distance Learning;Education;Electronics;Ensure;Epidemic;Epidemiology;Event;Faculty;Family health status;Federal Government;fighting;Funding;Future;global health;Goals;Growth;Health;high risk population;Historically Black Colleges and Universities;HIV;HIV risk;HIV Vaccine Trials Network;HIV/STD;Immunology;Infrastructure;innovation;Institution;Interdisciplinary Study;Interest Group;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Internships;Investments;Knowledge;Laboratories;Leadership;Link;Malawi;Malignant Neoplasms;member;Mentors;Microbiology;Newsletter;North Carolina;novel;novel therapeutics;Online Systems;outreach;Patients;Persons;Pharmacology;Population;Positioning Attribute;prevent epidemics;Prevention;programs;Public Health;Publishing;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resources;Risk;Schools;Services;Site;social media;social science research;Social Sciences;South Africa;South Carolina;Specimen;Strategic Planning;symposium;Talents;Technology;tool;Training;transgender women;Translational Research;transmission process;underrepresented minority student;Underserved Population;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Vietnam;virology;Work;working group;young men who have sex with men;Zambia

PROJECT_TITLE: The University of North Carolina Center for AIDS Research


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Typical visual environments are dynamic: object motion or navigation shifts visual information over the retina, challenging the brain to understand the world as an organized collection of objects. The proposed research will explore how the neural circuits that assign borders in visual scenes to foreground surfaces aid in predicting future visual input. Understanding these neural computations is important to develop better visual cortical prostheses and to yield insight into the aberrant scene perception that occurs in disorders such as visual agnosias or schizophrenia.

PI_NAMEs: FRANKEN, TOM P. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Anesthesia procedures;Area;area V4;artificial neural network;awake;Behavior;Biological;Brain;Chronic;Collaborations;Collection;Complex;Data;design;Diagnostic;Diet;Disease;dorsal visual stream;Environment;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;Funding Mechanisms;Future;Geometry;Goals;high reward;high risk;Human;Implant;in silico;innovation;insight;Lead;Macaca;Measurement;Motion;Movement;multi-electrode arrays;National Eye Institute;Nature;network architecture;neural;neural circuit;neural network;Neurons;neurophysiology;neuroprosthesis;neurotransmission;next generation;nonhuman primate;object motion;operation;Ownership;Perception;Performance;Population;Population Control;Positioning Attribute;Primates;Process;Property;Prosthesis;Psychophysics;receptive field;Research;response;Retina;Role;Schizophrenia;Shapes;Side;Signal Transduction;Stimulus;Stream;Surface;System;Texture;Theoretical model;Therapeutic;tool;Training;Travel;Vision;Visual;Visual Agnosias;Visual Cortex;Visual Fields;visual information;Visual Perception;visual processing;Work

PROJECT_TITLE: Exploring How Scene Segmentation Circuits Aid in Predicting Future Visual Input

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Overall Project Narrative The mission of the San Diego Center for AIDS Research (SD CFAR) is to drive HIV discoveries and foster cutting-edge research by San Diego investigators to improve the lives of people with HIV and to stop new infections, both locally and globally. The SD CFAR supports basic, clinical, behavioral and translational research programs across our member institutions and fosters the development of emerging investigators, including scientists new to HIV research.

PI_NAMEs: SMITH, DAVID MITCHELL (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academy;Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Area;base;Basic Science;Behavioral;Behavioral Research;Breathing;California;Cancer Education Grant Program;career;career development;Caring;Clinical;Clinical Research;Collaborations;Communities;community academic partnership;community engagement;community partners;Development;Educational workshop;Environment;equity, diversity, and inclusion;Evaluation;Feedback;Fostering;Foundations;Funding;Funding Opportunities;Future;Generations;Grant;Grant Review;Growth;health equity;health equity promotion;HIV;Hypersensitivity;Immunology;improved;Infection;innovation;Institution;Interdisciplinary Study;International;international partnership;Journals;Justice;Laboratories;Leadership;low and middle-income countries;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mission;next generation;NIH Office of AIDS Research;operation;Patients;Performance;Persons;Policies;prevent;Prevention;Productivity;programs;Publications;Reduce health disparities;repository;Research;Research Personnel;Research Priority;Research Support;Resources;Risk;Sampling;Scientist;Services;Strategic Planning;Structure;Surveys;synergism;Training;translational research program;transmission process;underserved community;United States National Institutes of Health;Universities;Work;working group


PROJECT_TITLE: San Diego Center for AIDS Research (SD CFAR)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: JOHNSON CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Pseudomonas aeruginosa can infect any tissue in the human body and is difficult to treat. This proposal will determine the regulation of a novel regulator of the type III secretion system. The results of this study will aid in developing improved therapeutic options for P. aeruginosa infections.

PI_NAMEs: PRITCHETT, CHRISTOPHER L. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute Pneumonia;Affect;Antibiotic Resistance;Attenuated;Cells;Clinical;combat;Data;Drug resistance;experience;Future;Genes;Genetic Transcription;Goals;Homeostasis;Human body;improved;In Vitro;in vivo;Messenger RNA;Morbidity - disease rate;mortality;Mus;Mutagenesis;novel;opportunistic pathogen;pathogen;Pathogenesis;Patients;pneumonia model;Post-Transcriptional Regulation;posttranscriptional;promoter;Promoter Regions;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas Infections;Regulation;Regulatory Element;resistant strain;Role;successful intervention;Testing;Therapeutic;Tissues;Toxin;transcriptomics;Type III Secretion System Pathway;Vaccines;Virulence;Virulence Factors

PROJECT_TITLE: PA1627: a new regulator of the Type III secretion system

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Enzymes called protein kinases are important regulators of cellular responses to environmental cues, and their deregulation is a hallmark of cancer. We will develop technology based around engineering of kinases and their protein substrates that will allow us to better understand how protein kinases carry out their functions in cancer cells. Understanding signaling pathways important for tumor cell survival and growth may suggest new therapeutic opportunities for treating cancer.

PI_NAMEs: TURK, BENJAMIN E (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: 5'-AMP-activated protein kinase;Alleles;Animals;Attention;Biological Models;cancer cell;Cancer cell line;cell behavior;Cell Extracts;cell growth;Cell Line;Cell Survival;Cells;Compensation;computerized tools;Cues;Cultured Cells;Cyclic AMP-Dependent Protein Kinases;Data;design;Engineering;Ensure;Enzymes;Exclusion;experimental study;Family;Future;Goals;Human;Knock-in;Knowledge;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Methodology;Methods;mutant;Mutation;neoplastic cell;novel therapeutics;Outcome Study;Output;Peptides;Phenotype;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Protein Engineering;Protein Kinase;Protein Kinase Protein Phosphorylation;Protein-Serine-Threonine Kinases;Proteins;reconstitution;Regulation;Resolution;response;Role;Serine;Signal Pathway;Signal Transduction;Site;Specificity;STK11 gene;structural determinants;Substrate Specificity;System;Techniques;Technology;Threonine;Tumor Suppressor Proteins;Western Blotting

PROJECT_TITLE: Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Recreating the complexity and properties found in human tissues remains a challenge in bioengineering. This proposal uses a tunable hydrogel platform to form complex cell-matrix adhesion that include ligands for both the integrin and syndecan protein families. The ability of these materials to better recapitulate the extracellular matrix will improve our ability to model tissues in the lab and deliver effective regenerative therapies in the clinic.

PI_NAMEs: PASHUCK, EUGENE THOMAS (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Actins;Address;Adhesions;Area;Biocompatible Materials;Biological Models;Biomedical Engineering;Biopolymers;cell behavior;Cell surface;Cell Surface Proteins;cell type;Cell-Matrix Junction;Cells;Clinic;Complex;design;Drug Screening;Engineering;ethylene glycol;experience;Extracellular Matrix;Focal Adhesions;Gel;Half-Life;Human;human tissue;Hydrogels;improved;In Vitro;in vivo;Individual;innovation;Integrin Binding;Integrins;Ligands;Measures;mechanotransduction;Mediating;Membrane Proteins;Mesenchymal Stem Cells;migration;Modulus;nanofiber;Natural regeneration;Nature;Osteogenesis;osteogenic;Peptides;Physiological;Physiological Processes;Play;Polymers;Property;Protein Family;Proteins;reconstitution;regenerative therapy;Relaxation;Research;Role;self assembly;stem cell differentiation;Stress;syndecan;System;technology platform;Testing;therapeutic development;Tissue Engineering;Tissue Model;tissue regeneration;Tissues;viscoelasticity

PROJECT_TITLE: Designing Hydrogels that Recapitulate Physiological Cell-Matrix Adhesions

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Lung;Networking and Information Technology R&D (NITRD)

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The research objective of this project is to develop a noninvasive, miniaturized, and wearable sensor monitoring carbon dioxide pressure in the blood. Our new technology is proposed as an alternative to the clinical practice of blood withdrawal to measure this parameter informing about the ventilation and respiratory effectiveness of the patient. This new device will allow the monitoring of vital respiration parameters continuously in real-time at home which will revolutionize the monitoring and treatment of numerous respiratory diseases, such as asthma and chronic obstructive pulmonary disease, which are amongst the principal cause of death and illness.

PI_NAMEs: GULER, ULKUHAN ;UNLUTURK, BIGE DENIZ  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: accurate diagnosis;Acute respiratory failure;Adult;Affect;Age;age group;Agreement;Algorithms;Asthma;bioelectronics;Biological Process;Blood;Blood capillaries;Blood gas;Blood specimen;Blood Tests;Carbon Dioxide;Caregivers;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;clinical practice;Computer Models;Computer software;cost;Coupling;Data;data acquisition;data integration;Data Set;data structure;design;Devices;Diagnosis;Differential Equation;Diffusion;Effectiveness;Elements;Environment;Exhalation;Film;Finite Element Analysis;Gender;Geometry;global health;Goals;Gold;Health;Heating;Home;Hospitals;Human;Human body;Humidity;improved;Inhalation;light weight;Literature;Location;luminescence;Lung;Lung Diseases;Measurement;Measures;Medical;Methodology;Methods;Miniaturization;miniaturize;miniaturized sensor;model building;Modeling;Monitor;Morbidity - disease rate;mortality;nanoscale;new technology;operation;Oxygen;Pain;Parameter Estimation;Partial Pressure;Pathologic;Patient Care;Patients;Persons;Physics;Physiological;Pilot Projects;Population;pressure;prevent;Procedures;Process;prototype;PtcO2;real time monitoring;remote monitoring;Research;Respiration;respiratory;Respiratory Disease;Risk;Running;sensor;sex;Shapes;Skin;Skin Tissue;Societies;Supervision;System;Techniques;Technology;technology development;Temperature;Thoracic Radiography;Time;Transcutaneous Blood Gas Monitoring;Translating;treatment strategy;trend;United States;Use of New Techniques;Validation;ventilation;Vision;wearable device;wearable sensor technology;wireless;Withdrawal;X-Ray Medical Imaging

PROJECT_TITLE: Computational Models for Smart CO2 Monitoring

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Kidney Disease;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: LAY NARRATIVE MCD, FSGS, MN, and IgAN are rare glomerular diseases of the kidney that cause serious illness including kidney failure and high mortality, generating enormous individual and societal burden. CureGN has assembled nephrologists, researchers with expertise in different scientific disciplines, and patients in a consortium that maintains and analyzes a large, longitudinal observational data and biosamples like blood, urine and images of kidney biopsies. This initiative has developed a critical infrastructure that will advance our ability to study, classify, characterize, diagnose, and treat primary glomerular diseases of the kidney.

PI_NAMEs: GADEGBEKU, CRYSTAL A.;MARIANI, LAURA H (contact);SMITH, ABIGAIL

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Achievement;actionable mutation;Address;Adult;Advocacy;Affect;Ancillary Study;APOL1 gene;biobank;Biocompatible Materials;Biology;biopharmaceutical industry;Biopsy;Blood;career development;Child;Childhood;Classification;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;community engagement;Consultations;Data;Data Collection;data collection methodology;Data Coordinating Center;Databases;Development;Diagnosis;digital pathology;Discipline;Disease;Disease remission;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Epigenetic Process;Etiology;Focal and Segmental Glomerulosclerosis;follow-up;Formalin;Fostering;Funding;Funding Agency;Future;Genetic;genome sequencing;Goals;Grant;Health Technology;Heterogeneity;high risk;high standard;IGA Glomerulonephritis;Immunologics;improved;Individual;Industry;industry partner;Infrastructure;innovation;International;Investigation;kidney biopsy;Kidney Diseases;Kidney Failure;kidney imaging;Knowledge;Longitudinal, observational study;Medical Record Linkage;Membranous Glomerulonephritis;metabolomics;Methods;mHealth;Michigan;Mission;mobile application;Modernization;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;Natural History;Nephrology;next generation;North Carolina;novel;observational cohort study;Observational Study;Outcome;Output;outreach;pandemic disease;Paraffin Embedding;Participant;participant retention;Pathogenesis;Pathology;patient advocacy group;Patient Care;patient engagement;Patient Outcomes Assessments;Patient Participation;Patients;Pattern;Pennsylvania;personalized care;Persons;Phase;Pilot Projects;Population;precision medicine;predict clinical outcome;Procedures;Process;Productivity;Professional Organizations;Prognosis;programs;prospective;Protocols documentation;Publications;Publishing;recruit;Renal glomerular disease;repository;Research;Research Personnel;risk variant;Role;sample collection;Sample Size;Science;Scientist;Services;Site;social;social health determinants;Standardization;Statistical Data Interpretation;Structure;Time;Tissue Embedding;tool;Training;transcriptome sequencing;Translational Research;treatment response;treatment strategy;Universities;Urine;Visit;whole genome;Work;working group

PROJECT_TITLE: CureGN

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: PROJECT NARRATIVE Volumetric muscle loss is the irrecoverable loss of muscle tissue that leads to life-long dysfunction or permanent disability. Current treatment options are extremely limited, and there are no physical rehabilitation or surgical standards of care. Using an animal model, the goal of this research is to develop a novel sensor to assess a promising treatment for volumetric muscle loss.

PI_NAMEs: REITER, ALEX J (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Aging;Animal Disease Models;Animal Model;Animals;Ankle;Architecture;Area;Autologous;Behavior;Biocompatible Materials;Biomechanics;Caring;Chronic;Clinical Research;comparative;comparison control;Contracts;Data;Development;Effectiveness;effectiveness evaluation;effectiveness validation;Electric Stimulation;Fiber;Flexor;Functional disorder;Functional impairment;functional restoration;Gastrocnemius Muscle;Generations;Goals;Health;Histologic;Histology;Human;human model;improved;in vivo;injured;Injury;insight;Kinetics;Lateral;Lifelong disability;locomotor tasks;Measurement;Measures;mechanical load;Methodology;Methods;miniaturize;Modeling;Muscle;muscle form;Muscle function;muscle grafts;muscle regeneration;Muscular Atrophy;muscular structure;Musculoskeletal;novel;Operative Surgical Procedures;Outcome;Pharmaceutical Preparations;Physical Rehabilitation;Physical therapy;Pre-Clinical Model;preclinical study;Property;Rattus;Recommendation;Recovery;Research;response to injury;Rodent;Rodent Model;Running;sensor;Speed;Stress;Study models;Techniques;Technology;Tendon force;Tendon structure;Therapeutic;tibialis anterior muscle;Time;Tissues;Torque;Training;treatment effect;treatment strategy;volumetric muscle loss;wearable sensor technology

PROJECT_TITLE: Noninvasive assessment of in vivo tissue loads following treatment of volumetric muscle loss

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Bioengineering;Biotechnology;Genetics;Infectious Diseases

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Bacterial persister cells are phenotypic non-growing variants that play important roles in chronic infections and facilitate the development and wide spread of bacterial multidrug resistance. This project aims to develop an optogenetic system and an animal model for controlling and monitoring persister formation in vivo, which are useful for fundamental studies of persister formation and for development of new control agents. Thus, it has significance in infection control, which is critical to public health.

PI_NAMEs: REN, DACHENG  (contact)

PROJECT_TERMS: Address;Aftercare;Animal Model;anti-toxin;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;Bacterial Model;Bacterial Physiology;Behavior;Biocompatible Materials;Biological;Bioluminescence;cell growth;Cell Wall;Cells;chronic infection;Control Groups;Darkness;design;Development;Devices;drug discovery;Drug resistance;efficacy testing;Engineering;Environment;Eosine Yellowish;Escherichia coli;Euthanasia;experimental group;Exposure to;falls;Fluorescence;Gender;Gene Expression Profile;Genes;Goals;Green Fluorescent Proteins;Growth;Health;Heavy Metals;Immune response;Immune system;Immunohistochemistry;Immunology;implantable device;implantation;improved;In Vitro;in vitro testing;in vivo;in vivo Model;Infection;Infection Control;Label;Light;light emission;Medical Device;medical implant;Microbial Biofilms;Microbiology;Modeling;Molecular Biology;Monitor;mouse model;Multi-Drug Resistance;multidrug tolerance;Multiple Bacterial Drug Resistance;Mus;mutant;Mutation;Nature;Normal Cell;optogenetics;pathogenic bacteria;persistent bacteria;Persons;Phenotype;Play;Population;Process;promoter;Protein Biosynthesis;Proteins;Public Health;real time monitoring;real-time images;Relapse;Repression;Research;resistance gene;resistant strain;response;Role;Silicon;Stains;Stress;subcutaneous;synthetic biology;System;Testing;Time;Tissues;Toxin;United States National Institutes of Health;Variant;Visualization;whole animal imaging;wireless

PROJECT_TITLE: Optogenetic Control of Bacterial Persistence to Study Biomaterial Infections

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative Opioid overdoses will cause the death of ~80,000 Americans in 2023. Narcan has stemmed the rate of increase in opioid deaths, but in some cases Narcan is ineffective, so alternative strategies are needed. This proposal will examine cannabidiol derivatives that have the potential to decrease opioid receptor signaling and improve the efficiency of Narcan in reversing opioid overdoses.

PI_NAMEs: MACKIE, KENNETH  (contact);STRAIKER, ALEXANDER J

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;abuse liability;Adenylate Cyclase;Affect;Affinity;Agonist;American;Analgesics;analog;antagonist;Arrestins;Attenuated;attenuation;Behavior;Binding;Cannabidiol;Cause of Death;Cells;Cessation of life;Dependence;Dissociation;Effectiveness;experimental study;Fentanyl;fentanyl overdose;Future;G protein-coupled inwardly-rectifying potassium channel;G-Protein-Coupled Receptors;Goals;improved;in vivo;insight;Lead;Libraries;Life;Ligands;MAPK3 gene;Mediating;Molecular Conformation;mu opioid receptors;Naloxone;naloxone dosing;novel;Opioid;Opioid agonist;opioid epidemic;opioid mortality;opioid overdose;Opioid Receptor;Pain;painful neuropathy;Pathway interactions;pharmacologic;Pharmacological Treatment;Phospholipase C;prevent;receptor;Receptor Activation;Receptor Inhibition;receptor internalization;Receptor Signaling;recruit;Rewards;scaffold;Signal Pathway;Signal Transduction;Site;Speed;stem;Tail;Therapeutic;Ventilatory Depression;Withdrawal;Work

PROJECT_TITLE: Negative allosteric modulation of mu opioid receptors to reverse fentanyl overdose

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Remote therapeutic monitoring is a new point of care mobile health solution designed to enhance patient engagement with physical therapy care, as well as improve patient-provider communication for those attending physical therapy. While remote therapeutic monitoring stands to improve patients’ experiences with physical therapy and improve the overall effectiveness of physical therapy care for patients with musculoskeletal pain, little to no research has been conducted examining the feasibility or effectiveness of integrating remote therapeutic monitoring into physical therapy. As such, we propose a phased research project (R21/R33) that we will examine the feasibility or implementing RTM into physical therapy care (R21), as well as its effects on patient-centered outcomes and health care utilization among patients attending physical therapy for musculoskeletal pain at a large academic hospital in the US (R33).

PI_NAMEs: MCLAUGHLIN, KEVIN  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Examining the Feasibility and Effectiveness of an mHealth Solution Designed to Enhance Clinical Outcomes Among Patients Attending Physical Therapy for Musculoskeletal Pain

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

PHR: Project Narrative Over the past several decades, genetic studies in animal models and in humans have identified and validated a number of longevity-associated genes. Together, these findings strongly suggest that modest changes in the expression of these genes can have significant impact on healthspan and lifespan. In this project, we will develop antisense oligonucleotides to modulate the levels of selected longevity-associated genes, and then test if they can extend lifespan and improve healthspan using a mouse model of accelerated aging.

PI_NAMEs: NGUYEN, ANDREW D. (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Address;age acceleration;Age Months;Aging;aging related;ANGPTL3 gene;Animal Model;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Base Pairing;behavioral study;Binding;Binding Sites;Biochemistry;Biological Markers;Cardiovascular Diseases;Cells;Cessation of life;Chemicals;Chronic Disease;Clinical Trials;cognitive function;cognitive testing;design;Diabetes Mellitus;Disease;Dose;Down-Regulation;Elderly;experience;experimental study;extend lifespan;Family;FDA approved;FGF21 gene;fibroblast growth factor 21;frailty;Gene Expression;gene function;Gene Mutation;Genes;Genetic;Genetic study;genetic variant;Growth;healthspan;Human;Human Genetics;IGF1 gene;IGF1R gene;Impairment;improved;in vivo;Individual;Inflammatory;inflammatory marker;insight;Lead;life span;Light;Longevity;Malignant Neoplasms;Measurement;Measures;Messenger RNA;Metabolism;MicroRNAs;Modality;model organism;Modification;Molecular Biology;mortality;mouse model;Mus;Muscle function;Neurodegenerative Disorders;neurofilament;novel therapeutics;Nutrient;pharmacologic;Pharmacology;Physiological;Plasma;Proteins;Research;Risk Factors;RNA;RNA Sequences;sarcopenia;senescence;Signal Transduction;SMN2 gene;Societies;superoxide dismutase 1;Syndrome;Technology;Testing;Therapeutic;Time;tool;Translations;Up-Regulation;Use of New Techniques;Wing

PROJECT_TITLE: Targeted Modulation of Longevity-Associated Genes Using Antisense Oligonucleotides

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_DEPT: PEDIATRICS

ORG_STATE: NC

PHR: PROJECT NARRATIVE Food allergies are a potentially life threatening disease with increasing prevalence, and while oral immunotherapy and sublingual immunotherapy are two therapies that can modify this disease, outcomes are extremely variable. Our research studies protein breakdown products called metabolites, and we found that children who develop remission of their food allergies on oral immunotherapy have higher levels of bile acids and other metabolites that are known to alter the immune system. Using studies of oral immunotherapy and sublingual immunotherapy in younger children, we will study changes in these bile acids and other metabolites that affect the immune system to learn more about how children develop remission of their food allergies and identify new targets for food allergy therapies.

PI_NAMEs: VIRKUD, YAMINI V (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Acids;adaptive immune response;Affect;Age;Allergen Immunotherapy;Allergens;Allergic;Allergic Reaction;Antibody Response;Arachidonic Acids;arm;Asthma;Basophils;Bile Acids;Biological Markers;biomarker identification;Cells;Cellular biology;Child;cohort;Consumption;cytokine;Data;desensitization;Development;Disease;Disease remission;Disparate;Dose;enzyme pathway;Food;food allergen;Food Hypersensitivity;Functional disorder;Goals;Histidine;Human;IgE;Immune;Immune response;Immune system;Immune Tolerance;Immunologic Markers;Immunologics;immunoregulation;Immunotherapy;immunotherapy trials;improved;Individual;Intervention Trial;Learning;Life;Mass Spectrum Analysis;Mediating;metabolomics;novel;novel therapeutics;oral immunotherapy;Outcome;Pathway interactions;Patients;Placebo Control;Plasma;Play;Prevalence;Proteins;Regulatory T-Lymphocyte;Remission Induction;Research;research study;response;response biomarker;Role;Sampling;Serology;sublingual immunotherapy;Symptoms;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic biomarker;therapeutic target;therapy development;Urocanic Acid;Work

PROJECT_TITLE: Metabolomics of Food Allergen Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: NARRATIVE Mutations in the gene GNB3 affect the function of the G-protein Gbeta3 subunit and lead to a variety of cardiovascular, metabolic and retinal disorders that currently have no cure. Our proposed research will determine the contribution of cone transducin Gbeta3 protein in retinal signaling and pathophysiology to establish foundation for further understanding of the disease mechanisms.

PI_NAMEs: KISSELEV, OLEG G (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Affect;age related;analog;Biochemical;Cardiovascular Diseases;cell type;Complex;Cone;Cornea;Darkness;Data;Development;Disease;DNA cassette;Electrophysiology (science);Electroretinography;Enterobacteria phage P1 Cre recombinase;experimental study;Foundations;Freezing;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Family;Genes;GNB1 gene;GNB3 gene;Goals;GTP-Binding Proteins;Human;inherited retinal degeneration;Knock-in;Knock-out;Laboratories;Length;Light Adaptations;light microscopy;Link;LoxP-flanked allele;Measurement;member;Metabolic Diseases;Metabolic syndrome;Modeling;Morphology;mouse model;Mus;Mutation;Night Blindness;novel therapeutic intervention;Obesity;Optical Coherence Tomography;Photophobia;Photoreceptors;Phototransduction;Physiological;Pilot Projects;Property;Proteins;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal rods;Rod;Rod Outer Segments;Role;selective expression;Signal Transduction;Specificity;Testing;Time;Tissues;Transducin;Transgenic Mice;Validation;Vertebrate Photoreceptors;Vision;Visual impairment;Western Blotting

PROJECT_TITLE: Conditional knock-in of Gnb3/Gngt2 in mouse rod photoreceptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Preventing adolescent suicide mortality: Exploring barriers and facilitators of school officials’ participation in child death review meetings Child death review (CDR) aims to prevent adolescent suicide mortality through multidisciplinary review teams, yet fewer than 3 in 10 review teams have participation from school representatives, representing a major implementation gap. Because adolescents spend considerable time in school, school representative participation in CDR reviews is a major undeveloped area of research for identifying mechanisms, correlates, and modifiable risk factors of adolescent suicide deaths. The goal of this mixed methods research is to explore school representatives’ barriers and facilitators to CDR participation and characterize leading barriers and facilitators, which leads to next steps of practice and policy interventions to improve their participation in CDR.

PI_NAMEs: BLOSNICH, JOHN RUDOLPH (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent suicide;Age;Area;Autopsy;Behavioral;Cause of Death;Cessation of life;Charge;Child;Child Abuse and Neglect;child protective service;community partners;Coroners and Medical Examiners;County;Data;Data Collection;Decision Making;Development;Equilibrium;experience;Exploratory/Developmental Grant;Family;Family member;Feeling suicidal;Fright;Funding;Goals;Health;health care service utilization;high risk;implementation barriers;improved;Individual;informant;Infrastructure;interest;International;Intervention;Interview;Investigation;Law Enforcement;Lawyers;Location;Los Angeles;Maternal and Child Health;Medical emergency;meetings;Mental disorders;Mental Health Services;Methodology;Methods;modifiable risk;mortality;multidisciplinary;National Institute of Child Health and Human Development;Online Systems;Only Child;Personal Satisfaction;Physicians;Policies;Population;Positioning Attribute;Prevalence;prevent;Prevention;Privatization;Process;Professional counselor;psychologic;Psychologist;Recommendation;recruit;Research;Research Methodology;Resources;Risk Factors;Sampling;Schools;Social Workers;Structure;suicidal adolescent;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;suicide mortality;Suicide prevention;Surveys;System;Testing;Time;Training;Translating;United States;United States Health Resources and Services Administration;Work;young adult

PROJECT_TITLE: Preventing Adolescent Suicide Mortality:  Exploring Barriers and Facilitators of School Officials' Participation in Child Death Review Meetings

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE There is an exponentially growing number of nanoparticles engineered to enhance the precise delivery of genetic material to the diseased tissue for safe and effective gene therapy. The ability to cross-compare multiple nanoparticles in a single animal offers a powerful opportunity for personalization across many clinical applications, all while reducing the time, resources, and money in the process. The proposed project aims to develop an effective, efficient, and enabling nano-tool for high-throughput screening of nanoparticles in animals to assess their individual’s preferential delivery to different diseased tissues.

PI_NAMEs: KIM, JAYOUNG  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Acceleration;Address;Animals;Artificial nanoparticles;Award;Bar Codes;Base Sequence;Behavior;Biodistribution;Biological;Biomedical Research;Clinical;clinical application;clinical translation;Communities;Consumption;cost;deep sequencing;delivery vehicle;design;Detection;detection method;Development;Disease;DNA;Drug Kinetics;Elements;Encapsulated;Engineering;Ensure;Evaluation;Exhibits;Formulation;Gene Delivery;Gene Library;gene therapy;Genes;Genetic;Genetic Materials;Goals;high throughput screening;in vivo;Individual;innovation;Intervention;Label;Libraries;lipid nanoparticle;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Molecular Weight;monomer;Mus;nano;nanolabel;nanoparticle;nanoparticle delivery;non-viral gene delivery;Non-Viral Vector;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleotides;Oligonucleotides;Organ;Peptoids;Performance;polypeptide;Process;Property;Protocols documentation;Recovery;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;RNA;RNA Degradation;Sampling;screening;Screening procedure;Services;sex;Side;side effect;Standardization;Structure;support tools;targeted delivery;Technology;Time;Tissues;tool;Tracer;transgene expression;vector;Vertebral column

PROJECT_TITLE: Development of peptoid-based barcodes for in vivo high-throughput screening of targeted nucleic acid delivery

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE. This research is a pioneering effort to unravel the complex interplay between ambient air pollution and adverse health outcomes through the development of innovative data analytic methodology. Our analysis spanning two decades of emergency department visits in Atlanta will quantitatively assess the health effects of several air pollution mixtures. Our findings will not only contribute to a deeper understanding of these relationships, but will also have implications for public health interventions, the establishment of air quality standards, and the formulation of evidence-based policy decisions.

PI_NAMEs: NABI, RAZIEH  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Affect;Air;Air Pollution;ambient air pollution;atmospheric chemistry;Chemicals;Communities;Complex;Complex Mixtures;criteria air pollutant;Data;Data Analytics;Data Set;Databases;design;Development;dimension reduction;Dimensions;Elements;Emergency department visit;Epidemiology;evidence base;Exposure to;fine particles;Formulation;Foundations;Gases;Goals;Health;health assessment;Health protection;high dimensionality;Human;improved;Individual;innovation;insight;interest;Joints;Literature;Masks;Metals;Methodology;Methods;Monitor;Nature;novel;novel strategies;Outcome;particle;Particulate;Personal Satisfaction;Policies;Policy Analysis;policy recommendation;pollutant;Pollution;Positioning Attribute;preservation;Preservation Technique;Public Health;public health intervention;Public Policy;Research;Risk Assessment;semiparametric;Source;stressor;Structural Models;Techniques;theories;Time;vapor;vector;volatile organic compound

PROJECT_TITLE: Causally-Sufficient Dimensionality Reduction Methods for Assessing Joint Effects of Air Pollution Mixtures on Health Outcomes

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Allogeneic mesenchymal stem cells (MSCs) are a promising cell source for treating inflammatory and immune- mediated diseases, but are targeted for death by the recipient immune system due to mismatched-major histocompatibility complex (MHC) molecules expressed on the cell surface. The aim of this proposal is to analyze how transforming growth factor-β2 (TGF-β2) regulates MHC expression in MSCs and how the recipient immune system responds to TGF-β2-treated MSCs in vivo. Results from the completion of these studies will support the generation of allogeneic donor MSCs that can be used “off-the-shelf” manner for safe and efficacious treatment.

PI_NAMEs: BERGLUND, ALIX K. (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Adverse effects;Affect;Allogenic;Animal Model;Antibodies;Autologous;career;Cell surface;Cell Therapy;Cells;cellular targeting;Cessation of life;Clinical;college;cost effective;cost effective treatment;cytotoxic;Data;Degenerative Disorder;Development;Disease;Doctor of Philosophy;Down-Regulation;efficacious treatment;Engraftment;Equus caballus;experience;Gene Expression Profiling;Gene Expression Regulation;Generations;Genetic;Genetic Transcription;Goals;Human;Immune;Immune Evasion;Immune response;Immune system;immunogenic;immunogenicity;Immunologist;Immunology;immunoregulation;improved;in vivo;Inflammatory;Injections;Interferon Type II;Knowledge;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Mediating;Mentored Research Scientist Development Award;Mentors;Mesenchymal Stem Cells;Molecular Immunology;mouse model;Mus;North Carolina;paracrine;Pathway interactions;Patients;prevent;Property;protein expression;Publishing;Qualifying;Research;Research Personnel;response;Safety;Scientist;Signal Pathway;Signal Transduction;Source;stem cell biology;stem cell therapy;Surface;systemic inflammatory response;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Training;Training Programs;transcription factor;Transforming Growth Factor Beta 2;Transforming Growth Factor beta Receptors;translational immunology;translational physician;translational potential;Universities;Veterinary Medicine;Work

PROJECT_TITLE: Manipulation of MHC expression using TGF-beta2 to reduce mesenchymal stem cell immunogenicity


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Uveitis is a group of ocular disorders characterized by increased inflammatory cells and protein levels inside the eye. This project aims to develop novel ways to use optical coherence tomography (OCT), an imaging technology with micrometer precision, to detect, grade, and monitor inflammatory cells and protein levels in the aqueous and vitreous humor of the eye so that proper treatment can be delivered on a timely basis. Artificial intelligence algorithms will be developed to analyze OCT images and differentiate the types of cells suspended in the aqueous and vitreous humor.

PI_NAMEs: LI, YAN  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Abbreviations;Acceleration;Adoption;analytical tool;Anterior;anterior chamber;aqueous;Aqueous Humor;Area;Artificial Intelligence;artificial intelligence algorithm;aspirate;Autoimmune Diseases;Award;Biological Markers;Blindness;Blood Cells;Categories;Cell Count;Cell Differentiation process;cell type;Cells;cellular imaging;Cellular Infiltration;Classification;Clinical;clinical practice;Clinical Research;Clinical Trials;convolutional neural network;Cost Savings;Data;deep learning;density;Diagnosis;Diagnostic;Differential Diagnosis;drug development;Etiology;Evaluation;experience;Eye;Eye diseases;Flare;Glossary;Goals;Hyphema;Image;imaging modality;Imaging technology;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;lens;Liquid substance;Location;Lymphocyte;Malignant Neoplasms;Measurement;Measures;meter;Monitor;monocyte;Needles;neutrophil;novel;Ophthalmology;Optical Coherence Tomography;Outcome Measure;Patient Monitoring;Patients;Pattern;Photography;Pilot Projects;Procedures;Proteins;Research Personnel;Resolution;Sampling;Severity of illness;System;Technology;Testing;Three-Dimensional Imaging;tool;Training;Treatment Efficacy;treatment response;ultra high resolution;United States;Uveitis;Vision;Visual;Vitreous humor;wound

PROJECT_TITLE: Quantification and Classification of Aqueous and Vitreous Inflammation in Uveitis Using Deep Learning Analysis of Ultrahigh-Resolution OCT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Human calcium-sensing receptor (CaSR) maintains extracellular Ca2+ homeostasis through regulation of parathyroid hormone secretion, and malfunction of CaSR is associated with calcium homeostatic disorders including life-threatening neonatal hypercalcaemic conditions. We are pursuing structure-based functional studies of the pleiotropic signaling pathways of the CaSR in order to elucidate the molecular determinants of its G protein selectivity and promiscuity. Our work will shed light on how naturally occurring mutations in the CaSR gene impact signaling to cause human diseases and initiate the exploration of precision pharmacotherapies targeting these mutations.

PI_NAMEs: FAN, QING R (contact);JAVITCH, JONATHAN A

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: absorption;Affect;Alzheimer's Disease;autosome;Binding Proteins;Biological Assay;Biological Process;Bioluminescence;Biosensor;Blood;Bone Diseases;Calcium;Calcium-Sensing Receptors;Cell Physiology;Cell surface;Cells;cinacalcet;Classification;Clinical;Complex;Cryoelectron Microscopy;Data;design;detection of nutrient;detector;Disease;disease-causing mutation;Dissociation;DNA Sequence Alteration;Energy Transfer;Equilibrium;Event;extracellular;Fetal Development;Future;G-Protein-Coupled Receptors;gain of function;Goals;GTP-Binding Proteins;Guanine Nucleotides;Homeostasis;Hormone secretion;Human;human disease;Hyperparathyroidism;Hypocalcemia;Infant;information gathering;insulin secretion;Intestines;Kidney;Life;Link;loss of function;Lung;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Mediating;Metabolic;Metabolism;Minerals;Molecular;Monitor;mutant;Mutation;Neonatal;Nervous System;neuronal excitability;Organ;Parathyroid gland;Pathway interactions;Pharmacotherapy;Physiological;Play;positive allosteric modulator;precision medicine;Precision therapeutics;protein activation;Protein Binding Domain;Protein Family;PTH gene;receptor;receptor function;Receptor Gene;Receptor Signaling;Regulation;Role;Serum;Signal Pathway;Signal Transduction;Signaling Protein;Skeleton;Specificity;Structure;Surface;therapeutic target;Work

PROJECT_TITLE: Pleiotropic pathways of extracellular calcium sensing

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Serious Mental Illness;Sleep Research;Women's Health Research

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother- infant bonding. Insomnia precedes over half of PND cases and may serve as an entry point for interventions preventing PND. The proposed project is a large-scale clinical trial to test the effectiveness of a mindfulness- based sleep program designed for pregnant women to improve sleep and alleviate cognitive arousal to reduce risk for PND across pregnancy and postpartum.

PI_NAMEs: DRAKE, CHRISTOPHER L (contact);KALMBACH, DAVID ADDISON

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Affect;Aftercare;alertness;arm;Arousal;Awareness;behavioral sleep intervention;Caring;Clinic;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;Complication;Consensus;COVID-19 pandemic;Data;Dedications;depression prevention;depressive symptoms;design;diagnostic criteria;diaries;digital;direct application;Disease;DSM-V;Education;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness-implementation RCT;effectiveness/implementation hybrid;Ensure;Etiology;evidence base;Feeling suicidal;follow-up;General Population;Health system;High Risk Woman;Impairment;improvement on sleep;Incidence;Infant;innovation;interest;Intervention;Leadership;Maintenance;Major Depressive Disorder;maternal risk;Maternal-fetal medicine;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;Mind;mindfulness;mindfulness intervention;Mission;modifiable risk;Mothers;Nurses;Outcome;Patients;Perinatal;perinatal complications;perinatal mental health;perinatal outcomes;peripartum depression;Personal Satisfaction;Population;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;prevent;Prevention;Preventive care;preventive intervention;Private Practice;programs;prospective;Provider;Psychologist;Race;Randomized;recruit;Relapse;Reporting;Research;response;Risk;Risk Factors;Risk Reduction;rumination;Sampling;Severities;Sleep;Sleep Disorders;sleep health;sleep onset;Sleeplessness;socioeconomics;Suicide;Symptoms;Telemedicine;Testing;Therapeutic Intervention;Time;Translating;Translations;United States Preventative Services Task Force;Woman;Women's Health;women's treatment

PROJECT_TITLE: Sleep to Reduce Incident Depression Effectively in Peripartum - (STRIDE P)

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Aging-related neurodegenerative diseases affect millions of people worldwide and occur when cells in the nervous system lose function over time and ultimately die. One of the challenges in treating these disorders lies in the complex genetic interplay that drives disease progression. By investigating the interaction between C9orf72 HRE and TMEM106B and exploring the toxicity of TMEM106B fibrils, this study aims to uncover essential mechanisms underlying brain aging and neurodegeneration in FTD.

PI_NAMEs: TILAHUN, KEDAMAWIT  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;age related neurodegeneration;Aging;aging brain;aging population;aging related;ALS patients;Amyloid Fibrils;Anti-sense RNA;Antibodies;Brain;C-terminal;C9ORF72;Cells;Code;Cognitive deficits;Complex;Coupled;Data;Dementia;Dipeptides;Disease;Disease Progression;DNA Sequence Alteration;DNA-Binding Proteins;Drosophila genus;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;fused in sarcoma;Genes;Genetic;genome wide association study;Haplotypes;Human;Immunoprecipitation;In Situ Hybridization;Individual;Induced Neurons;induced pluripotent stem cell;inhibitor;insight;Integral Membrane Protein;Label;Link;link protein;Locomotion;Lysosomes;Mass Spectrum Analysis;Measures;Molecular;Morphology;multicatalytic endopeptidase complex;Mus;Mutation;N-terminal;Nature;Negative Staining;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuron loss;Neurons;neurotoxicity;Nuclear;Nuclear Export;Nuclear Import;Nuclear Pore;Nuclear RNA;nucleocytoplasmic transport;Nucleocytoplasmic Transport Proteins;Older Population;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Play;Population;Pore Proteins;protein expression;protein TDP-43;Proteins;Reporter;Research;Risk;risk variant;RNA;RNA-Binding Proteins;Role;Single Nucleotide Polymorphism;Stains;stem;System;Testing;Time;Toxic effect;Translations;Transmission Electron Microscopy;Work

PROJECT_TITLE: Exploring TMEM106B in Neurodegeneration: Protein Interaction and Fibril-induced Neurotoxicity

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it aims to develop a novel approach for testing the function of the primate prefrontal cortex in decision-making and other forms of executive function. Such an approach would significantly improve the ability to understand the basis of cognition in the healthy primate brain, and therefore would provide opportunities to improve the diagnosis and treatment of diseases in which cognition is compromised, including substance abuse, depression, eating disorders, OCD, schizophrenia, and others. The findings are therefore expected to be relevant to the part of NIH’s mission pertaining to behavioral and mental health, in particular the missions of NIMH and NIDA.

PI_NAMEs: MCGINTY, VINCENT B (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Animal Model;Area;Attention;attentional bias;Behavioral;behavioral health;Brain;Choice Behavior;Code;Cognition;Cognitive;cognitive function;Complement;Complex;Data;Decision Making;density;Development;Diagnosis;Disease;Dorsal;Eating Disorders;economic value;Economics;Electric Stimulation;Electrodes;Etiology;executive function;experience;experimental study;Goals;high risk;Human;improved;Lateral;Link;Macaca;Mediating;Mental Depression;Mental Health;Methods;Mission;Monkeys;Motor;National Institute of Drug Abuse;National Institute of Mental Health;neural;neural patterning;neural prosthesis;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;Neurosciences;neurotransmission;next generation;novel;novel strategies;Outcome;Pattern;Prefrontal Cortex;Primates;Process;Prosthesis;Public Health;Research;Role;Sampling;Schizophrenia;selective attention;Sensory;Short-Term Memory;Signal Transduction;social cognition;Specificity;Structure;Substance abuse problem;System;Techniques;Testing;United States National Institutes of Health

PROJECT_TITLE: A novel technique for selective manipulation of prefrontal computations in economic choice

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DC

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Nutrition;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project narrative The mosquito disease vector, Aedes aegypti, is troubling because it spreads viruses that cause diseases such as dengue, yellow fever, and Zika, which infect >100,000,000 people/year. The identification of opsins as the first bitter taste receptor in mosquitoes offers the potential for identifying receptor antagonists to improve the efficacy of attractive toxic sugar baits, and reduce populations of insect disease vectors, and human disease. In addition, identifying mammalian opsins as the first receptor for the bitter compound, naringin, which is a common bitter ingredient in grapefruit and other fruit, provides the possibility of isolating antagonists for this receptor, to improve the palatability of many nutritious fruit that promote human health.

PI_NAMEs: MONTELL, CRAIG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Aedes;Amino Acids;Animals;antagonist;Behavior;behavior test;Behavioral Assay;Biological Assay;Blood;Catechin;Cellular biology;Chemicals;chromophore;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Culicidae;Data;defined contribution;Dengue;Detection;detector;Development;Diet;dietary;Disease;Disease Vectors;Drosophila genus;egg;Electrophysiology (science);Esthesia;Evolution;experience;experimental study;Family;fascinate;feeding;Female;Flavonoids;fly;Fruit;G-Protein-Coupled Receptors;Genetic;genetic manipulation;Goals;Grapefruit;Health;Homologous Gene;Human;human disease;Image;Impairment;improved;In Vitro;in vitro Assay;in vivo;insect disease vector;Insecta;interest;Ligand Binding;Ligands;Light;male;Mammals;member;Modality;Modeling;Molecular Genetics;Motivation;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Neurons;Nutrient;Nutritional;Opsin;Organ;Partner in relationship;Persons;Photoreceptors;Plants;Poison;Population;Production;Property;Proteins;receptor;Receptor Activation;Receptor Cell;response;Rhodopsin;Role;Specificity;sugar;Taste Buds;Taste Perception;Testing;Tongue;tool;transcriptome;transcriptome sequencing;Transgenic Organisms;vector;Vertebrate Photoreceptors;Virus;Visual System;Vitamin A;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Opsins as a new class of evolutionarily conserved taste receptors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The most common form of hearing loss is caused by the death of hair cells in the cochlea. Young mammals are capable of regenerating some hair cells, but this ability disappears by the time they are old enough to hear. In our proposal, we will use genetic reprogramming to drive cells of the inner ear to produce new hair cells, and to understand the mechanisms through which this reprogramming can happen in clinically-relevant conditions.

PI_NAMEs: GROVES, ANDREW K (contact);RAPHAEL, YEHOASH

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acute;Affect;age related decline;Alleles;animal old age;Animals;Cause of Death;Cells;Chronic;Clinical;clinically relevant;Cochlea;comparative efficacy;Complement;Consensus;Data;deaf;deafening;deafness;Ear;Ectopic Expression;Embryo;Engineering;Environment;Epigenetic Process;Epithelium;experimental study;feasibility testing;Future;Genes;Genetic;Genetic Engineering;Genetic Transcription;GFI1 gene;guinea pig model;hair cell regeneration;Hair Cells;Hearing;hearing impairment;Human;improved;Injury;Intervention;Labyrinth;Mammals;Minority;Morphology;Mus;Natural regeneration;Neonatal;Organ of Corti;Pathology;Patients;regeneration potential;regenerative;regenerative approach;Regenerative capacity;response;Sensorineural Hearing Loss;Severities;success;Supporting Cell;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptomics;transdifferentiation;Transgenic Organisms;Type II Hair Cell;Utricle structure;Vertebrates;vestibular system

PROJECT_TITLE: Enhancing Atoh1 function in hair cell regeneration

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative  This study proposes to finalize the development of a smartphone AI-app-based intervention for adolescent electronic cigarette (e-cigarette) cessation using a formative evaluation process and to pilot test the app as a summative evaluation. To achieve this, this study will attempt to develop and test a feasible, effective, scalable program using a smartphone application, which can be deployed to a large pool of adolescents through schools, primary care clinics, and community settings. Developing an AI-enhanced program is promising for addressing the emerging health threats of e-cigarette use among adolescents because such programs can provide individualized contents based on user profiling techniques and provide immediate help to manage cravings based on real-time recorded data.

PI_NAMEs: PARK, EUNHEE  (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: 20 year old;Abstinence;addiction;Address;Adolescent;adolescent health;Alcohols;Artificial Intelligence;Artificial Intelligence enhanced;Belief;Benchmarking;Cellular Phone;chatbot;Chronic Disease;Clinical;combustible cigarette;Communities;community setting;comparison control;Control Groups;cost effective;craving;Data;depressive symptoms;design;Development;disorder prevention;e-cigarette cessation;effective intervention;effectiveness testing;Electronic cigarette;electronic cigarette use;electronic cigarette user;Evaluation;experience;feasibility testing;Feedback;formative assessment;Frequencies;group intervention;Health;Health Promotion;High School Student;Intention;Intervention;intervention delivery;Interview;Marijuana;Mental Health;Middle School Student;Mindfulness Training;Nicotine;Nicotine Dependence;Outcome;Participant;participant interview;patient engagement;Patient Self-Report;Pattern;Perception;performance tests;Persons;Phase;physical conditioning;pilot test;post intervention;primary care clinic;Problem behavior;Process;programs;Public Health;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Readiness;Reporting;Research;Research Design;Research Personnel;response;Risk;Schools;Self Efficacy;smartphone application;substance use;Surveys;Symptoms;Task Performances;Techniques;Testing;therapy design;Time;tobacco user;Training Activity;usability;user-friendly

PROJECT_TITLE: AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: The proposed research is relevant to public health because it focuses on identifying key alternative poly- adenylated mRNA isoforms underpinning the detrimental action of pathological tau oligomers that characterize various tauopathies including Alzheimer’s disease (AD) and AD related dementia (ADRD). This is ultimately expected to drive the development of a novel, effective preventive/curative therapy for AD and tauopathies, thus improving patients’ health while driving down the societal cost for their care, which is expected to increase to unbearable proportions by the year 2050. Thus, the proposed research is relevant to the part of NIH’s mission concerned with fostering creative discoveries by new generation of neuroscientists, and their application to advance the nation’s capacity to protect and improve human health.

PI_NAMEs: MONTALBANO, MAURO  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Affect;age group;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease therapy;Automobile Driving;Award;Binding;Biochemical;Biological;Brain Diseases;Brain region;career;Caring;Cell Fractionation;Cell model;Cell Nucleus;Cellular Assay;Code;Creativeness;curative treatments;Data;Dementia;Development;Disease;DNA;DNA Binding;Early Diagnosis;Eukaryotic Cell;Evaluation;experimental study;Exposure to;Fostering;Frontotemporal Lobar Degenerations;Functional disorder;Funding;Funding Opportunities;Future;Gene Expression;Gene set enrichment analysis;Generations;Genes;Genetic Transcription;genome wide association study;Health;Hippocampus;Human;improved;in vivo;in vivo Model;Injections;innovation;insight;intermolecular interaction;Length;Libraries;Mediating;Messenger RNA;Methods;Microtubules;Mission;Molecular;monomer;mouse model;mRNA Expression;Mus;mutant;Mutation;Nerve Degeneration;Neurofibrillary Tangles;Neurons;novel;Nuclear;Outcome Study;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Physiological;polyadenylated messenger RNA;Polyadenylation;Polyadenylation Pathway;Positioning Attribute;Post-Transcriptional RNA Processing;Post-Translational Protein Processing;posttranscriptional;prevent;Preventive;primary outcome;professor;Protein Isoforms;Proteins;Public Health;Publications;Publishing;Regulation;Reporting;Research;Research Personnel;Resources;RNA;RNA Binding;RNA Processing;RNA-Binding Proteins;Role;Sampling;Site;societal costs;tau aggregation;tau mutation;tau Proteins;Tauopathies;Technology;Testing;therapy development;Transcript;transcriptome sequencing;Translations;United States National Institutes of Health;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Tau-RNA crosstalk: Alternative Poly-Adenylation (APA) Regulation in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Liver Disease;Microbiome;Neurosciences;Nutrition;Obesity

ORG_CITY: College Station

ORG_DEPT: NUTRITION

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: PROJECT NARRATIVE Public Health Relevance: Organophosphate flame retardants and their metabolites can be detected at relatively high levels and frequencies in indoor air, dust, food items, and human biospecimen. A mechanistic understanding of how mid-life exposure to an OPFR impacts on metabolic and brain aging is critical. The data obtained from the proposed studies will provide preclinical evidence for the causal link between TPHP-induced dysbiotic microbes and the pathophysiology of aging.

PI_NAMEs: WU, CHIA-SHAN  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acute;Adult;Aerobic;Age;age related;Aging;aging brain;aging related;Automobile Driving;Bacteroidetes;blood glucose regulation;Brain;building materials;Butyric Acids;Catabolism;Cell Physiology;chemical property;Child;cognitive function;cohort;Colon;consumer product;Data;developmental toxicity;diet-induced obesity;Dust;dysbiosis;Electronics;Endocrine;Endocrine disruption;Environment;Environmental Risk Factor;Epithelial Cells;Etiology;experimental study;Exposure to;Fatty Liver;fecal microbiome;fecal transplantation;Fire - disasters;Firmicutes;Flame Retardants;Food;Frequencies;Functional disorder;Furniture;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Health;Hepatotoxicity;High Fat Diet;Human;Impaired cognition;Impairment;improved;In Vitro;in vivo;Indoles;indoor air;Inflammation;Inflammatory;innovation;inorganic phosphate;Insulin Resistance;insulin sensitivity;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Lactic acid;Link;Liver;Long-Term Effects;Longitudinal Studies;Mediating;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;metabolome;metabolomics;Microbe;microbial;microbial community;microbiome;microbiota;middle age;Modeling;Mus;National Health and Nutrition Examination Survey;neuroinflammation;novel;Nuclear Receptors;Obesity;obesogenic;old mice;Organophosphates;oxidation;Oxygen;Pathogenesis;pathogenic bacteria;Pathologic;Pathology;Pathway interactions;Perinatal Exposure;persistent organic pollutants;Phenotype;Physiology;polybrominated diphenyl ether;Population;pre-clinical;Propionic Acids;Proteobacteria;public health relevance;Regulation;Reporting;Risk Reduction;Sampling;senescence;Serum;systemic inflammatory response;Testing;Thinness;Tissues;Tryptophan;Tryptophan Metabolism Pathway;urinary;Volatile Fatty Acids;young adult

PROJECT_TITLE: The impact of organophosphate flame-retardant exposure on metabolic and brain aging

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative After our considerable progress in reducing the need for anesthesia during pediatric MRI scans, this work aims to further reduce anesthesia through faster imaging, greater motion-robust acquisition and reconstruction tech- niques, and less need for intravenous access. Developments will focus on the clinical testbed of MRI for Inﬂam- matory Bowel Disease, a particularly challenging exam for children. This will make MRI safer, cheaper, and more widely available to children, reducing the population risk of radiation from CT.

PI_NAMEs: LUSTIG, MICHAEL ;VASANAWALA, SHREYAS S (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Abdominal Pain;Acceleration;Address;Adult;Algorithms;Anesthesia procedures;base;Breathing;cancer risk;Caring;Child;Child Care;Childhood;Clinical;clinical practice;Clinical Research;clinical translation;commercialization;Computational Technique;contrast enhanced;data acquisition;Dedications;deep learning;Dependence;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Ensure;Evaluation;experience;Exposure to;Frequencies;Funding;Gadolinium;Gases;Glucagon;Goals;gut inflammation;Healthcare;Height;high dimensionality;Image;Image Enhancement;image reconstruction;imaging modality;imaging system;improved;Inflammatory Bowel Diseases;innovation;Institution;Intestinal Obstruction;Intestines;Intravenous;invention;Ionizing radiation;Legal patent;Licensing;Magnetic Resonance Imaging;Methods;Modality;Morphologic artifacts;Motion;Motivation;MRI Scans;multidisciplinary;Nausea;novel;Oral;Pain;Patients;Peristalsis;Pharmaceutical Preparations;Phase;Physiologic pulse;Population;Prevalence;programs;Protocols documentation;Radiation;radiation risk;reconstruction;Rectum;Resolution;Respiration;Risk;Scanning;Sensitivity and Specificity;Small Intestines;soft tissue;spatiotemporal;Speed;success;System;T2 weighted imaging;Techniques;Technology;temporal measurement;Testing;timeline;translational study;Tube;Validation;validation studies;Vomiting;Work

PROJECT_TITLE: Rapid and Robust Pediatric MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Breastfeeding, Lactation and Breast Milk;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE In this study, we will investigate whether the type of antibiotic prescribed gives better outcomes. As well, we will make significant contributions towards understanding current racial disparities in practices of prescribing antibiotics to treat breastfeeding-related mastitis. These critical research areas need to be addressed to give clinicians and patients the information about which treatments work best and identify areas where randomized trials are needed.

PI_NAMEs: LUDEMA, CHRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Abscess;Academy;Address;Affect;alternative treatment;antenatal care;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Birth;Black race;Breast;Breast Feeding;burden of illness;Caring;Cephalosporins;Childbirth;Clinical;clinical practice;cohort;Combined Modality Therapy;Communicable Diseases;Communities;compare effectiveness;cost;Data;Data Set;design;Diagnosis;Disparity;effective therapy;Effectiveness;Epidemiologist;Equity;Ethnic Origin;Etiology;Evidence based treatment;experience;Fever;Future;Generations;Geography;Goals;Health;health care availability;health equity;Health Personnel;Healthcare;high risk;Hospitalization;Hospitals;Hour;implicit bias;improved;Infection;innovation;Lactation;Latina;Left;lincosamide;mastitis;Measurable;Medicine;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Minority Groups;minority health;Monitor;neglect;novel;Observational Study;Outcome;Pain;pain reduction;pathogenic bacteria;patient oriented;Patients;Pattern;Penicillins;Persons;Pharmaceutical Preparations;Physiological;Policies;Population;Pregnancy;prenatal;Protocols documentation;Provider;Race;racial disparity;randomized trial;Recommendation;Recovery;relative effectiveness;Research;response;Sepsis;septic;Severities;social;Streptococcus;Sulfonamides;Symptoms;targeted treatment;Time;transmission process;treatment comparison;treatment disparity;Treatment Failure;treatment guidelines;Treatment Protocols;Work

PROJECT_TITLE: Improving treatment of lactation mastitis: leveraging claims data to fill evidence gaps

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Axolotl salamander limbs are anatomically and functionally similar to human limbs, yet, unlike humans, they can be completely regenerated throughout life following amputation, providing clues for future therapeutic approaches toward stimulating limb regeneration in patients. Here, we develop a precise map of all the cells and their gene expression patterns during embryonic development, and we investigate newly-identified putative stem cells relevant to axolotl limb regeneration. These studies will reveal information about stem cells that will be important for understanding how they relate to the development and regeneration of the axolotl limb.

PI_NAMEs: WHITED, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Algorithms;Ambystoma;Amputation;Amputees;Anatomy;Animal Model;Atlases;Attention;Biological Process;blastema;CCRL2 gene;Cell Communication;Cell Cycle Checkpoint;Cell Lineage;cell type;Cells;Cellular biology;Cluster Analysis;Data;Development;Diabetes Mellitus;Digit structure;Disease;Distal;Distant;Embryo;embryo cell;Embryonic Development;Evolution;Fibroblasts;Foundations;Future;Gene Expression Profile;Generations;Genes;Genetic;Genetic Markers;Genetic study;Geography;Goals;Growth;Human;Injury;Knowledge;Lateral;Life;Limb Development;limb loss;Limb Prosthesis;limb regeneration;Limb structure;Mammals;Maps;Mesoderm;Modeling;Modernization;Molecular Genetics;Mus;Natural regeneration;Nature;new technology;novel;Patients;Play;Population;Positioning Attribute;Prevalence;Process;progenitor;Proliferating;Prosthesis;Public Health;Rana;regenerative biology;Regenerative capacity;Regenerative Medicine;Regenerative research;Reporting;Research;Research Personnel;Resolution;Resources;response;Rest;Risk Factors;Role;Salamander;Signal Transduction;single-cell RNA sequencing;Site;Source;Split-Pool Ligation Transcriptome sequencing;stem cell differentiation;stem cell fate specification;stem cell population;stem cell self renewal;stem cells;Structure;Tadpoles;Therapeutic;Time;Tissue Differentiation;tissue regeneration;Tissues;tool;Transcript;Transcriptional Regulation;Transplantation;tumorigenesis;Work

PROJECT_TITLE: An axolotl embryogenesis single-cell reference atlas to enable lineage-based developmental and regenerative studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (02)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Auditory processing abnormalities (e.g. auditory hypersensitivity and reduced auditory spatial attention) are common and prominent features in neurodevelopmental disorders such as autism spectrum disorder (ASD). The long-term goal is to investigate the mechanisms how altered myelination and brain connectivity impair auditory processing in neurodevelopmental disorders. A better understanding of the contributions of the neural mechanisms underlying the auditory processing abnormalities to ASD will help guide better therapeutic strategies for individuals with ASD.

PI_NAMEs: KIM, JUN HEE (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Age;Attention;Attentional deficit;Auditory;Auditory Brainstem Responses;auditory processing;Auditory system;autism spectrum disorder;autistic children;Autopsy;Axon;behavior test;Behavioral;behavioral phenotyping;Bilateral;Brain;Brain Diseases;Brain region;Brain Stem;Cell Lineage;Cell Nucleus;Cells;Communication;conditional knockout;Cre lox recombination system;density;Development;Developmental Delay Disorders;Disease;Electrophysiology (science);Equilibrium;Event;Exhibits;Fiber;Functional disorder;Functional impairment;Gene Expression Profile;Genes;Goals;Hearing problem;Human;Hypersensitivity;Impairment;In Vitro;in vivo;individuals with autism spectrum disorder;Knockout Mice;Link;loss of function mutation;Mediating;Modeling;Molecular;mouse model;Mus;Mutation;Myelin;myelination;Nerve;Nervous System;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuroimaging;neuromechanism;neuronal excitability;Neurons;neurotransmission;neurotropic;new therapeutic target;novel;oligodendrocyte lineage;Oligodendroglia;postnatal development;Proliferating;regional difference;Research;Role;Sensory;Signal Transduction;social;sound;Speed;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Testing;Therapeutic;Transmission Electron Microscopy;transmission process;voltage;Western Blotting;white matter

PROJECT_TITLE: Role of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum Disorder

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative The proposed research is relevant to public health because preimplantation uterine fluid regulation is crucial for several early pregnancy events and its dysregulation is associated with two public health issues: infertility and contraception. This proposal aims to investigate uterine fluid dysregulation as a mechanism for contraception, an area that has not been investigated but some observations implicate its importance. The completion of the proposed studies will not only fill in the knowledge gap about preimplantation uterine fluid dysregulation for conception, but also provide insights into optimizing and developing hormonal contraceptives targeting uterine fluid.

PI_NAMEs: YE, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: absorption;Adverse effects;Agonist;antagonist;Area;Bicarbonates;Body Weight;Cell membrane;clinical application;Clinical Research;Conceptions;Contraceptive methods;contraceptive target;differential expression;Dose;early pregnancy;Embryo;Embryonic Development;emergency contraception;Endocytosis;endometriosis;Epithelium;Event;Female Contraceptive Agents;Fertilization;Genes;Genotype;Hormonal;hormonal contraception;Horns;Impairment;Implant;Infertility;Infusion procedures;insight;Ion Channel;Knowledge;Left;Ligation;Liquid substance;male;Mammals;Mediating;Methods;Mifepristone;Molecular;mouse model;Movement;mRNA sequencing;Mus;natural Blastocyst Implantation;novel;Nuclear;Oils;Ovulation;Partner in relationship;Patients;Permeability;pill;Pilot Projects;Play;preimplantation;Progesterone;progesterone receptor A;Progesterone Receptors;Public Health;Regulation;Reporting;reproductive;Research;response;Role;Saline;side effect;Signal Transduction;spatiotemporal;Testing;Time;Tissue Banks;Tissues;transcription factor;uterine receptivity;Uterus;Visualization;Water;water channel;Woman

PROJECT_TITLE: Dysregulation of uterine fluid movement as a mechanism of contraception

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: COLLEGE STATION

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Tuberculosis (TB) is one of the top causes of death in humans worldwide, with children accounting for about half of those deaths. It is not understood how the TB bacteria resist viruses (phage) that can infect and kill them, making it important to explore how the bacteria resist viruses to help us develop innovative ways to treat TB using viruses, particularly in the face of ongoing increases in drug-resistance. Knowledge gained from these studies will help us to better fight tuberculosis.

PI_NAMEs: CIRILLO, JEFFREY D. (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Accounting;antimicrobial;Archives;Bacillus;Bacteria;bactericide;Bacteriophage Typing;Bacteriophages;Bioinformatics;Biology;Cause of Death;Cessation of life;Child;Classification Scheme;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Cytolysis;Development;DNA;DNA Sequence;DNA sequencing;Drug resistance;Drug resistance in tuberculosis;Electron Microscopy;Environment;Environment and Public Health;Epidemic;fighting;genetic analysis;Genome;genome analysis;genome sequencing;Genomics;Human;Immune;Immunity;Infection;innovation;insight;Knowledge;Lytic;Mind;Molecular;Molecular Target;Morphology;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;Netherlands;Nonlytic;novel;novel strategies;novel therapeutics;Pattern;Phenotype;Predisposition;Property;receptor;Recombinants;Research;Resistance;restriction enzyme;Site;Specificity;System;Therapeutic;Time;Translations;Tuberculosis;tuberculosis treatment;Virus;whole genome

PROJECT_TITLE: Examination of phage resistance and susceptibility in M tuberculosis

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Modeling human amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) has been challenging, with current stem cell-based and animal systems showing mild or limited phenotypes. The lack of models that recapitulate disease phenotypes impedes the development of much needed therapies. Here, we aim to establish direct fibroblast-to-neuron conversion, which preserves epigenetic age, as a novel system to understand human ALS and associated frontotemporal dementia.

PI_NAMEs: MILLER, TIMOTHY M. (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Acceleration;Adult;Age;Aging;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animals;Antisense Oligonucleotides;Bypass;C9ORF72;cell age;Cell model;Cells;Cessation of life;Collaborations;Communities;comparison control;Data;Dedications;Development;Disease;Disease Marker;disease phenotype;DNA Sequence Alteration;drug development;Embryo;Epigenetic age;epigenetic clock;Epigenetic Process;Excision;extracellular;familial amyotrophic lateral sclerosis;Fibroblasts;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genetic Markers;genetic variant;Human;human disease;human model;Huntington Disease;In Vitro;in vitro Model;Induced Neurons;induced pluripotent stem cell;Inherited;knock-down;laboratory experience;Link;Mediating;Methodology;microRNA biomarkers;MicroRNAs;Modeling;Motor Neurons;mutant;Mutation;mutation carrier;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neuromuscular;Neurons;novel;novel therapeutics;Nuclear Pore;Onset of illness;overexpression;Participant;Pathogenesis;Pathologic;Pathology;Patients;Persons;Phenotype;Postdoctoral Fellow;preservation;Process;protein aggregation;protein TDP-43;Proteins;Research;Research Project Grants;sex;Specificity;Spinal Cord;sporadic amyotrophic lateral sclerosis;stem cell model;stem cells;Stress;stressor;Study models;superoxide dismutase 1;System;Tauopathies;Testing;Therapeutic Agents;tool;transcription factor;transcriptomics;Universities;Washington;Work

PROJECT_TITLE: Directly Converted Neurons as a Novel Cellular Model for ALS and FTD


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Structural racism in the forms of residential segregation, concentrated poverty, and limited access to education and employment opportunities results in a disproportionate burden of community violence exposure (CVE) among Black youth. Despite the disproportionate burden of community violence and associated health inequities among Black youth, effective culturally and contextually responsive models of care are lagging. The proposed study seeks to address CVE with a pediatric health care model focused on healing rather than risk to empower minoritized and systematically oppressed CVE urban families.

PI_NAMEs: DINIZULU, SONYA J (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Affect;African American;Age;aged;anti-racism;Appointment;Area;Black race;brief intervention;Caregivers;Caring;Case Management;Chicago;Child;Child health care;Chronic;Cities;Clinic;Clinical assessments;Communities;community burden;community violence;coping;Data;design;Development;Disparity;Distal;distrust;Education;effectiveness study;effectiveness/implementation trial;Employment Opportunities;empowerment;Epidemiologist;ethnic disparity;Factor Analysis;Family;Feasibility Studies;follow-up;Funding;Gender;Goals;gun violence;healing;health care model;health care service utilization;health disparity;health inequalities;health literacy;Healthcare;Heterogeneity;implementation science;Individual;Individual Differences;injured;innovation;Interdisciplinary Study;Intervention;Interview;Lead;literacy;Literature;Measures;Medical;Medical center;Medicine;Mental Health;Mental Health Services;Methods;metropolitan;Minority;Modeling;Needs Assessment;neighborhood disadvantage;novel;Outcome;Participant;Patient Self-Report;pediatric patients;pediatrician;Persons;physical conditioning;post intervention;Poverty;Prevalence;primary caregiver;programs;Protocols documentation;Provider;provider adherence;psychologic;Public Health;Race;racial disparity;Recovery;Reporting;residential segregation;Risk;Safety;Sampling;Scientist;segregation;Services;Severities;Side;Site;social;social stigma;Social Work;Source;Stress;Structural Racism;Structure;Surveys;Symptoms;Target Populations;Testing;Trauma;treatment planning;United States Substance Abuse and Mental Health Services Administration;Universities;Violence;violence exposure;Youth

PROJECT_TITLE: Responding to Community Trauma: A Feasibility and Effectiveness Study of An Interdisciplinary Anti-Racist, Structurally Competent, and Culturally Responsive Assessment Model

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Mechanisms of learning and memory and their dependence on behavioral contexts have important implications in memory disorders such as Alzheimer's disease and age-related dementia, as well as post-traumatic stress disorders. The olfactory bulb adult neurogenesis presents an excellent model for studying experience- dependent plasticity. We propose to study the cellular and circuit mechanisms for the context specificity of synaptic structural plasticity of adult-born neurons in the olfactory bulb.

PI_NAMEs: KOMIYAMA, TAKAKI  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Adult;adult neurogenesis;Affect;Age;age related;Alzheimer's Disease;Apical;Area;Behavioral;Behavioral Mechanisms;Brain;Calcium;Cells;Clinical;Dementia;Dendrites;Dendritic Spines;density;Dependence;Diagnosis;Discrimination;discrimination task;Disease;Emotional;Ensure;Event;experience;Feedback;Future;Glutamates;granule cell;Head;Image;in vivo;in vivo calcium imaging;in vivo two-photon imaging;inhibitory neuron;insight;Learning;Memory;Memory Disorders;Methodology;Modeling;Monitor;Mus;neural circuit;Neuronal Differentiation;Neuronal Plasticity;Neurons;odor discrimination;Odors;olfactory bulb;Olfactory Learning;Olfactory Pathways;optogenetics;Pathway interactions;Pattern;piriform cortex;Play;Post-Traumatic Stress Disorders;Process;recruit;Reporting;Role;Specificity;Stimulus;structural imaging;Structure;Study models;Synapses;Synaptic plasticity;Techniques;Testing;two-photon;Vertebral column;young adult

PROJECT_TITLE: Context-dependent plasticity of adult-born neurons

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Lung

ORG_CITY: Auburn

ORG_DEPT: CHEMISTRY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Though the physicochemical properties of aerosols play a key role in respiratory virus transmission and in the effective delivery of drugs to the lungs, a comprehensive understanding of these properties has been hindered by the absence of high-quality in situ measurement techniques. This project aims to develop a fluorescence- based experimental apparatus capable of in situ measurements of the phase state, viscosity, and pH of size- resolved fine and ultrafine respiratory and drug aerosols. The eventual application of this instrument to characterize respiratory and drug aerosols will advance our ability to understand, predict, and control airborne virus transmission and pulmonary drug delivery.

PI_NAMEs: OHNO, PAUL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;aerosolized;Aerosols;Affect;Charge;Coagulation Process;density;Dependence;Deposition;Detection;Development;Diffusion;disease transmission;Disinfection;Dose;Drug Delivery Systems;drug efficacy;effective therapy;Ensure;fine particles;flu transmission;Fluorescence;Fluorescent Probes;Health;Heating;Human;Humidity;In Situ;Individual;Inhalation;instrument;instrumentation;interest;Ionic Strengths;Kinetics;Knowledge;Lasers;Location;Lung;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Microscopy;Modeling;Molecular;Morphologic artifacts;Nature;Optics;Outcome;particle;Particle Size;Pathway interactions;Pharmaceutical Preparations;Phase;Play;Positioning Attribute;Property;Raman Spectrum Analysis;Research;respiratory;respiratory aerosol;Respiratory Disease;respiratory disease/disorder therapy;respiratory virus;Role;Sampling;seasonal influenza;Systemic disease;technique development;Techniques;Technology;Temperature;Testing;Transmission Electron Microscopy;transmission process;Ultrafine;ultrafine particle;uptake;Variant;viral transmission;Virus;Viscosity;Volatilization;Wettability

PROJECT_TITLE: Development of aerosol fluorescence spectrometer for measuring multiple physicochemical properties of respiratory and drug particles in situ

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed study will investigate the organization of speech sound representations in the developing brain from childhood to adolescence. In addition to its overall organization for speech, we will determine how the brain is able to segment continuous speech sounds in different contexts, including when speech is self- generated or occurs in the presence of noise or other competing information. Understanding such processes will inform developmental milestones for brain development, and could lead to brain-based treatments of language disorders delayed language learning and dyslexia.

PI_NAMEs: HAMILTON, J LIBERTY S (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: 1 year old;Acoustics;Address;Adolescence;Adolescent;Adult;Age;age related changes;Anterior;Aphasia;Area;Articulation Disorders;Attention;attentional modulation;Auditory;Auditory area;Auditory Perceptual Disorders;autism spectrum disorder;behavior measurement;Bilateral;Biological Markers;Brain;brain based;brain computer interface;Child;Childhood;Classification;Communication;comorbidity;Complex;Data Set;Detection;Development;Disease;Dyslexia;early childhood;educational atmosphere;Electrophysiology (science);Epilepsy;Event;expectation;experimental study;Face;Genetic Transcription;Goals;Human;improved;innovation;insight;Intervention;Intractable Epilepsy;Language;Language Delays;Language Development;Language Development Disorders;Language Disorders;Learning;Linguistics;Location;Measures;Methods;Motor;neural;neurodevelopment;neurofeedback;neuromechanism;neurophysiology;Noise;Operative Surgical Procedures;Organizational Change;Participant;Patients;pediatric patients;Perception;Phonetics;phonological awareness;phonology;phrases;Procedures;Process;Production;Research;research clinical testing;Resolution;response;Role;Signal Transduction;social;sound;spatiotemporal;Speech;Speech Development;Speech Disorders;speech in noise;Speech Perception;speech processing;Speech Sound;Stimulus;Superior temporal gyrus;Temporal Lobe;temporal measurement;Testing;therapeutic target;verbal;Voice;Wernicke Area;Work

PROJECT_TITLE: Electrophysiological Approaches to Understanding Functional Organization of Speech in the Brain

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]