NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Telomere maintenance is essential for genome stability and the prevention of cancer and degenerative diseases. The proposed research will examine how environmental genotoxic and oxidative stress cause accelerated telomere shortening, and the pathways that preserve damaged telomeres. This project will reveal how various forms of telomeric DNA damage impact telomere function, cellular function and organism health.

PI_NAMEs: OPRESKO, PATRICIA L (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Acceleration;Animal Model;Award;base;cancer cell;cancer prevention;carcinogenesis;Cell Culture Techniques;Cell Physiology;Cell Proliferation;cell type;Cells;Chromosomes;Chronic;Degenerative Disorder;DNA Damage;DNA lesion;Environment;Excision Repair;experimental study;flexibility;Functional disorder;Funding;Generations;Genetic;Genome Stability;Genotoxic Stress;Goals;Guanine;Health;Human;human tissue;innovation;Knowledge;Learning;Lesion;Maintenance;Measures;model organism;Mus;National Institute of Environmental Health Sciences;nucleobase;Organ;Organism;Outcome;Oxidative Stress;Pathway interactions;Phase;Phenotype;Population;preservation;programs;Proliferating;Proteins;repaired;Research;System;Technology;telomere;telomere damage;telomere loss;Telomere Maintenance;Telomere Shortening;tool;Transgenic Organisms;Translating;Work;Zebrafish

PROJECT_TITLE: Excision Repair of Environmental Telomere Damage


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cerebrovascular;Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The final stage of lung development begins late in pregnancy and continues through the first decade of life. Infants born prematurely often require treatments, including oxygen and mechanical ventilation, that harm new blood vessels that drive postnatal lung development, resulting in the chronic lung disease of infancy, bronchopulmonary dysplasia (BPD). This proposal uses state-of-the art imaging, molecular, and computational tools to understand the role of pericytes, in promoting postnatal lung development, with the overall goal to discover new strategies to prevent and treat BPD.

PI_NAMEs: ALVIRA, CRISTINA MARIA;CORNFIELD, DAVID N. (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Affect;Alveolar;angiogenesis;Area;Basement membrane;Biological;Birth;Blood capillaries;Blood Vessels;brain pericytes;Bronchopulmonary Dysplasia;carbohydrate binding protein;carbohydrate receptor;Cell Communication;cell motility;Cell Proliferation;Cells;ChIP-seq;Coculture Techniques;computerized tools;Contracts;Data;Development;Diameter;Disease;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Erythropoietin;experimental study;Exposure to;gain of function;Gases;Gene Expression Profile;Genes;Genetic;Goals;Growth;Hyperoxia;Hypoxia;Hypoxia Inducible Factor;Image;Impairment;In Vitro;in vivo;Individual;Injury;insight;Knockout Mice;Life;loss of function;Lung;Lung Capacity;lung development;Mechanical ventilation;Mediating;Mesenchymal;Microcirculation;migration;Molecular;Morphogenesis;mouse model;Mus;Myofibroblast;Natural regeneration;neonatal exposure;neonatal lung disease;neonatal mice;normoxia;Oxygen;paracrine;Pathway interactions;Pattern;Pericytes;Phenotype;Physiological;Play;Polysaccharides;postnatal;postnatal development;Pregnancy;Premature Infant;preservation;prevent;Proliferating;promoter;pup;Regulation;Relaxation;Reporter;Resolution;Role;sensor;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stimulus;Surface;Testing;therapy development;Time;transcription factor;transcriptome;transcriptomics;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Smooth Muscle

PROJECT_TITLE: Pericytes and postnatal alveolarization: Role of hypoxia inducible factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: KANSAS CITY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative This research project is aimed to explore a novel and phosphorylation-depenent mechanism for the regulation of metabotropic glutamate receptors and to define the role of metabotrpic glutamate receptors in the pathophysiology and symptomatology of a common mental illness (major depressive disorder). The information obtained through this project is valuable for advancing the knowledge on biology of glutamate receptors related to depression and for the development of new pharmacotherapies for preventing and treating depression.

PI_NAMEs: WANG, QIANG  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Adult;Affinity;Amino Acids;Animals;Behavior;Binding;Biochemical;Biology;Brain;C-terminal;calmodulin-dependent protein kinase II;Chronic stress;Corpus striatum structure;Coupling;Cyclic AMP;Data;depressive behavior;depressive symptoms;Development;Dopamine D1 Receptor;Event;Functional disorder;Glutamate Receptor;Glutamates;Heterodimerization;Homo;In Vitro;in vivo;inhibitor;interdisciplinary approach;Knowledge;Link;Major Depressive Disorder;Mediating;Mental Depression;Mental disorders;metabotropic glutamate receptor 2;Metabotropic Glutamate Receptors;Modeling;Molecular;Monitor;Moods;Mus;mutant;Nerve;neuroadaptation;neurochemistry;Neurons;novel;Pathogenesis;Pathway interactions;Peptides;pharmacologic;Pharmacotherapy;Phosphorylation;Phosphotransferases;Physiology;Pilot Projects;Play;Predisposition;presynaptic;Presynaptic Receptors;prevent;Property;Protein Biochemistry;Protein Chemistry;protein function;Proteins;Rattus;Reaction;receptor;receptor function;Receptor Signaling;Regulation;Research Project Grants;response;Rewards;Role;Series;Signal Transduction;Site;Social isolation;Source;Specificity;Surface;symptomatology;Synaptic Transmission;System;Tail;Testing;Threonine;Time;trafficking;Transgenic Organisms

PROJECT_TITLE: Molecular Regulation of Metabotropic Glutamate Receptors in Striatal Neurons

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE A major problem in the treatment disorders of motivation such as addiction is the probability of relapse, even after protracted remission periods, when at-risk populations are faced with drug-associated triggers. Clinical experience indicates that there are few effective approaches for use in crisis intervention, stabilization and harm reduction. Here we will explore the role of the endocannabinoid system as a potential pharmacological target with promising therapeutic value in a broad spectrum of conditions involving compromised motivational states. Through the experiments proposed herein, we will gain a better understanding of the neurobiological mechanisms triggering maladaptive cue-driven renewal of reward seeking in the treatment of motivational disorders.

PI_NAMEs: CHEER, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: 2-arachidonylglycerol;addiction;Adult;Animals;Behavior Control;behavior influence;Behavioral;Brain;CCL4 gene;Cell membrane;Cell Nucleus;Cells;Clinical;CNR1 gene;Crisis Intervention;Cues;Data;Disease;Disease remission;Disinhibition;Dissection;Dopamine;dopaminergic neuron;drug craving;drug withdrawal;Educational process of instructing;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Environment;Enzymes;Ethology;expectation;experience;experimental study;Funding;Genetic;Globus Pallidus;GTP-Binding Proteins;Harm Reduction;In Vitro;Infrastructure;insight;Knowledge;Learning;Link;lipoprotein lipase;Maps;Mediating;Membrane;Messenger RNA;Methodology;Midbrain structure;motivated behavior;Motivation;motivational processes;mouse model;Mus;Negative Reinforcements;neural;neurobiological mechanism;Neuromodulator;Nucleus Accumbens;optogenetics;Organism;Outcome;Output;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Population;Populations at Risk;Positive Reinforcements;postsynaptic;Probability;Process;Production;Punishment;receptor;receptor expression;recruit;Relapse;Rewards;Role;Signal Transduction;Site;Stimulus;superior colliculus Corpora quadrigemina;Technology;Testing;theories;Therapeutic;Time;tool;Training;Transgenic Mice;Transgenic Model;treatment strategy;Ventral Tegmental Area;Work

PROJECT_TITLE: Endogenous Cannabinoid Control of Reward Substrates


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Malaria is a life-threatening disease caused by Plasmodium parasites and the development of an effective malaria vaccine is key to shifting the fight against malaria towards elimination. This project will develop and evaluate the efficacy of a multi-modal vaccine against blood-stage parasites formulated with a novel human- compatible liposomal adjuvant, using a non-human primate model of human malaria. The rational inclusion of the two parasite components is expected to result in strain-transcending neutralizing antibodies induced by a structure based AMA1-RON2L vaccine that will synergize with a broad cellular response induced by the whole blood-stage antigens to maximise control of the blood-stage parasite and confer protection against P. falciparum blood-stage infection.

PI_NAMEs: SRINIVASAN, PRAKASH  (contact);STANISIC, DANIELLE

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Address;Adjuvant;Age;Amino Acids;Antibodies;Antigen Presentation;Antigenic Diversity;Antigens;Aotus primate;apical membrane;arm;Binding;biological sex;Blood;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Cessation of life;Child;Clinical;clinical development;Clinical Trials;Complex;Country;Data;design;Development;Disease;Dose;Drug resistance;efficacy evaluation;fighting;Generations;Genetic Polymorphism;Goals;Human;human model;Immune;Immune response;Immune system;Immunity;immunogenicity;Immunology procedure;In Vitro;Individual;Infection;insight;Interferon Type II;Life;liposomal formulation;Liposomes;Malaria;Malaria Vaccines;Mediating;Memory B-Lymphocyte;Modeling;Molecular Conformation;Monkeys;Morbidity - disease rate;mortality;multimodality;Mus;neutralizing antibody;nonhuman primate;novel;parasite invasion;Parasite resistance;Parasites;phase III trial;Plasmodium;Plasmodium falciparum;pre-clinical;preclinical efficacy;preservation;prevent;Primates;protective efficacy;Proteins;Reproducibility;response;Role;single-cell RNA sequencing;Structure;Subunit Vaccines;success;Swiss Mice;synergism;System;T cell response;Technology;Testing;Transcend;Vaccine Antigen;vaccine candidate;vaccine immunogenicity;vaccine-induced immunity;Vaccines;Vulnerable Populations;Whole Blood

PROJECT_TITLE: Developing a multi-component vaccine harnessing potent antibody and cellular responses against the blood-stage of Plasmodium falciparum

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE Innovative and integrated approaches are needed to further understanding the basic mechanisms underlying neuronal plasticity that contribute to the pathophysiology of neuropsychiatric disorders, and thereby enable future development of effective therapeutic interventions. Through a multidisciplinary project including biophysics, molecular biology, biochemistry, imaging and single cell electrophysiology in rodent experimental models, we will identify novel bio-signatures of neuron vulnerability to disease based on neurotrophin-mediated regulation of the voltage-gated Na+ channel.

PI_NAMEs: LAEZZA, FERNANDA  (contact)

PROJECT_TERMS: Area;Axon;Behavioral Paradigm;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biological Psychiatry;biomarker development;Biophysics;biosignature;Brain;Brain-Derived Neurotrophic Factor;Cell Physiology;Cells;Cellular Assay;cellular imaging;cellular targeting;Co-Immunoprecipitations;Complement;Complex;Development;Disease;Electrophysiology (science);Ensure;environmental enrichment for laboratory animals;Experimental Models;Fibroblast Growth Factor;fibroblast growth factor-14;Functional disorder;Future;Gene Transfer;Genetic;glycogen synthase kinase 3 beta;Glycogen Synthase Kinases;Grant;Image;Immunoprecipitation;In Vitro;in vivo;Induced Neurons;innovation;interest;Ion Channel;Knowledge;Lasers;Link;Long-Term Potentiation;Luciferases;Macromolecular Complexes;Maps;Mediating;Methods;Microscopy;Molecular;Molecular Biology;multidisciplinary;National Institute of Mental Health;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neurotrophic factor;novel;Nucleus Accumbens;Outcome Study;patch clamp;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Predictive Factor;Predisposition;prevent;Property;protein protein interaction;Proteins;public health relevance;Rattus;receptor;reconstitution;Regulation;resilience;response;reward dysfunction;Rewards;Rodent;Role;Scanning;SCN8A gene;Signal Transduction;Site;Slice;Social isolation;Sodium Channel;Stimulus;subcellular targeting;Synapses;Therapeutic Intervention;therapeutically effective;Tropomyosin;ultra high resolution;Variant;Viral Vector;voltage

PROJECT_TITLE: Neurotrophin-dependent regulation of voltage-gated sodium channels

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because a better understanding of the etiology of autism will lead to improved methods for prevention and treatment. This proposal focuses on both common and rare genetic variants because together they provide an integrated understanding of the genetic risk for autism. It also proposes to investigate risk for autism in people of Hispanic/Latin American ancestry, an under-represented population in prior studies.

PI_NAMEs: BUXBAUM, JOSEPH D. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;autism spectrum disorder;autism symptoms;Caring;case control;Clinical;clinical phenotype;cohort;comorbidity;Complex;Copy Number Polymorphism;Data;disorder risk;Encapsulated;Enrollment;Epilepsy;Equity;Etiology;European ancestry;exome sequencing;Future;gene discovery;Gene Dosage;Gene Expression;Genes;Genetic;genetic analysis;genetic architecture;genetic association;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Heritability;Hispanic;Hispanic Populations;improved;Individual;Inherited;insertion/deletion mutation;Intellectual functioning disability;Latin American;Latina;Latino Population;Latinx;Latinx population;Maps;Medical;Methods;Minority Groups;National Institute of Mental Health;non-genetic;Nucleotides;Parents;parity;Phenotype;polygenic risk score;Population;portability;Prevention;proband;psychiatric genomics;Public Health;recruit;Research;Risk;risk variant;Sampling;Single Nucleotide Polymorphism;Site;Subgroup;Testing;transmission process;Underrepresented Populations;United States;Variant

PROJECT_TITLE: Genomics of Autism in Latinx Ancestries

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative To serve as a catalyst to generate knowledge and translate it into successful strategies to prevent, treat and cure HIV infection, we organized the Einstein/Rockefeller/CUNY-Center for AIDS Research (ERC-CFAR). The ERC- CFAR brings together a highly synergistic partnership of complementary resources by linking a strong basic and clinical research institution `treating a large patient base of people with HIV (Einstein), a globally pre-eminent basic science institution (Rockefeller), and a strong public health/implementation science institution (CUNY) to energize and mobilize our complementary basic, translational, clinical, epidemiologic, behavioral, and implementation research programs to attain our shared goal of Ending the HIV Epidemic.

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adherence;Affinity;AIDS prevention;antiretroviral therapy;Area;Award;base;Basic Science;Behavioral;Behavioral Research;Behavioral Sciences;behavioral study;Biological Markers;catalyst;chimeric antigen receptor T cells;Cities;Clinical;clinical center;Clinical Research;Clinical Sciences;Collaborations;college;Communities;Community Health;community partners;Country;County;Data;Development;Diagnosis;economic disparity;Eligibility Determination;Epidemic;Epidemiology;epidemiology study;Failure;Financial Support;forging;Funding;Future;Goals;Grant;Health;Health system;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Immunologic Adjuvants;Implant;implementation research;implementation science;implementation strategy;Improve Access;improved;Infection;Inflammatory;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Knowledge;Lead;Leadership;Link;Location;Logistics;Medicine;member;Mental disorders;Mental Health;Mentors;Modality;National Institute of Mental Health;neurochemistry;neutralizing antibody;New York;New York City;next generation;novel;novel therapeutics;Outcome;pandemic disease;Paper;Pathogenesis;Patients;Persons;Play;Population;pre-exposure prophylaxis;prevent;Prevention;preventive intervention;Process;Productivity;programs;Prophylactic treatment;Public Health;Public Health Schools;Publications;Publishing;recruit;Research;Research Personnel;Research Priority;Resources;response;Role;scale up;Services;Site;social disparities;Strategic Planning;success;synergism;Technology;therapy adherence;Translating;Translational Research;transmission process;United States;United States National Institutes of Health;Universities;uptake;Vacuum;Viral;Viremia;Vision;working group

PROJECT_TITLE: ERC Einstein-Rockefeller-CUNY Center for AIDS research


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pitch and harmonicity are both crucial factors in the perception of music, speech, and auditory scene analysis, but the question of how they are perceived and represented in the human auditory cortex remains mostly unknown. This project uses a combination of behavior, electrophysiology (EEG), and neuroimaging techniques (fMRI) to further our understanding of cortical representations and the temporal processing of pitch and harmonicity. This research will extend our understanding of pitch processing in normal-hearing individuals, which will help inform the development of pitch processing strategies in auditory prostheses, such as cochlear implants, that are currently unable to provide robust pitch information.

PI_NAMEs: MEHTA, ANAHITA H (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Cortical Representations of Harmonic and Virtual Pitch in Humans

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Advisory Committees;Behavioral;career;Clinical;Collaborations;college;Communication;Communities;County;Development;Education;Electronic Mail;Ensure;Epidemic;Epidemiology;Faculty;Fostering;Funding;Goals;Grant;Growth;Health;HIV;HIV diagnosis;HIV Infections;implementation process;improved;Infrastructure;Institution;Interdisciplinary Study;International;Lead;Leadership;Location;Medicine;meetings;member;Mental Health;Monitor;multidisciplinary;New York City;Newsletter;novel strategies;novel therapeutics;Occupational activity of managing finances;Outcome;Outcome Measure;Paper;Performance;prevent;Process;Productivity;programs;Public Health Schools;Publications;Recommendation;recruit;Research;Research Personnel;Research Priority;Resources;response;Scientific Advances and Accomplishments;sound;Strategic Planning;Structure;success;Surveys;synergism;Training;United States;United States National Institutes of Health;Universities;Update;uptake;web site;working group

PROJECT_TITLE: ERC Einstein Rockefeller CUNY Center for AIDS Research


PI_NAMEs: PRASAD, VINAYAKA R. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Supplement;Applications Grants;Award;career;Catalytic Domain;Clinical;Clinical and Translational Science Awards;cohort;Collaborations;Communication;Communities;Consultations;Data;design;Development;Epidemic;experience;Faculty;Feedback;Funding;Goals;Grant;Growth;Hepatitis C virus;HIV;HIV/AIDS;Individual;innovation;Institution;interest;Investments;Learning;Manuscripts;meetings;member;Mental Health;Mentors;Monitor;New York City;Paper;Participant;Pathway interactions;peer coaching;Peer Review;Pilot Projects;Privatization;Process;programs;Publications;Publishing;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Sampling;Series;Services;Simplexvirus;skills;Structure;Study Section;success;symposium;synergism;Teacher Professional Development;Translational Research;Underrepresented Minority;United States National Institutes of Health;virology;virtual;Virus;Work


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Pediatric

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Generally, adolescents living with HIV (ALHIV) have poor outcomes with higher rates of disengagement from care and higher mortality rates compared with other age groups especially during the transition period. Transition success may be maximized for ALHIV who are better prepared to negotiate care in adult clinic settings but majority of adolescents and young adults with HIV do not have the necessary skills to negotiate their own care by the time they are transitioned to adult care. This application proposes to develop a self- management intervention that is developmentally tailored for ALHIV to obtain the skills they need to successfully navigate adult HIV clinic following transition and optimize health outcomes for a key population in the global HIV epidemic.

PI_NAMEs: ASHABA, SCHOLASTIC  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Africa South of the Sahara;age group;Anti-Retroviral Agents;Applications Grants;Area;Award;behavior test;Behavior Therapy;Behavioral;Behavioral Sciences;care systems;career;Caregivers;Caring;Cause of Death;Childhood;Clinic;Clinical;Cognitive;Complement;critical developmental period;critical period;Data;Death Rate;design;Development;Education;effectiveness evaluation;Elements;Epidemic;Focus Groups;follow-up;Funding;Goals;Health;Health Personnel;HIV;HIV-infected adolescents;improved;Intervention;Interview;journal article;Knowledge;Mediation;Mental Depression;Mentors;Mentorship;mortality;Outcome;Patient Self-Report;pediatrician;Peer Review;Pharmaceutical Preparations;Pharmacy facility;pill;Population;post intervention;Preparation;primary outcome;Problem Solving;Psychiatry;psychoeducation;Psychosocial Assessment and Care;Public Health;public health relevance;Qualitative Research;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Infrastructure;Research Personnel;resilience;Resources;Rural;Sampling;secondary outcome;Self Efficacy;Self Management;skills;skills training;social stigma;standard of care;success;Testing;theories;Time;Training;treatment adherence;Treatment outcome;Uganda;UNICEF;Viral;Viral Load result

PROJECT_TITLE: Self-Management among adolescents living with HIV in Uganda

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: This Collaborative Merit Award application (CMA) is a synergistic, multidisciplinary project focused on the mechanistic understanding of platinum resistance (PtR) as the foremost cause of death in ovarian cancer patients. The overall strategy is to integrate ideas, resources, and expertise in advanced technologies to identify and validate novel therapeutic targets and biomarker-driven treatments for ovarian cancer patients. This application (CMA1) will identify biomarkers and underlying molecular pathways of platinum resistance as well as test potential targeted therapies that prevent or overcome PtR. CMA1 is highly integrated with the other two applications and will serve as a resource for CMA2 and CMA3 to identify and validate biomarkers and molecular mechanisms of platinum resistance. The major contribution of CMA1 is to generate a comprehensive integrated mechanistic multi-omic database that will facilitate the development of biomarker-driven mechanism-based cancer therapies for extending survival and improving the quality of life of Veteran women.

PI_NAMEs: ORSULIC, SANDRA  (contact)

PROJECT_TERMS: Address;Apoptosis;Architecture;Area;ASF1A gene;Autophagocytosis;Award;bioinformatics tool;Biological Assay;Biological Markers;Biological Models;biomarker development;biomarker driven;biomarker identification;biomarker validation;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;Catalytic Domain;Cause of Death;Cell Line;Cells;Cellular biology;Cessation of life;Characteristics;Chemoresistance;chemotherapy;Chromatin;chromatin remodeling;Chromosome Mapping;Clinical;Clinical Data;Clinical Management;clinically relevant;Coculture Techniques;Collaborations;Data;data integration;data modeling;Data Set;Databases;Dependence;Development;Diagnosis;digital;Disease Resistance;DNA Repair Pathway;Drug Addiction;Drug Compounding;Drug Screening;drug sensitivity;Drug Targeting;druggable target;efficacy testing;Evaluation;Event;Experimental Models;Fatal Outcome;fatty acid oxidation;Fibroblasts;Gene Expression;Genes;genetic signature;Glycolysis;Goals;Histologic;Histopathology;Hypoxia;Image;Image Analysis;Imaging Device;Immunocompetent;improved;inhibitor;Knowledge;Link;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Membrane Lipids;Membrane Transport Proteins;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolism;Methods;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Morphology;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;Mutate;Nature;Necrosis;neoplastic cell;Neuroendocrine Cell;neuroendocrine differentiation;neuroendocrine phenotype;Neurosecretory Systems;new therapeutic target;novel;novel strategies;novel therapeutic intervention;NUAK1 gene;Nuclear;Organoids;ovarian neoplasm;Ovarian Serous Adenocarcinoma;oxidized lipid;Pathologist;Pathology;Pathway interactions;Patient Care;patient derived xenograft model;Patients;Peptides;personalized medicine;Pharmaceutical Preparations;Phenotype;Platinum;Population;pre-clinical;Predisposition;pressure;prevent;Primary Neoplasm;protein expression;Proteome;Quality of life;Recurrence;Recurrent disease;refractory cancer;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Resources;Role;Sampling;Serous;Slide;spectroscopic imaging;standard care;stem cell biomarkers;stemness;Systems Biology;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapeutic biomarker;therapeutic target;therapy resistant;Tissues;transcriptome;Treatment Efficacy;treatment strategy;tumor;Tumor Debulking;tumor microenvironment;Validation;Veterans;Woman;women's diagnosis;Xenograft Model

PROJECT_TITLE: BCCMA: Overcoming chemoresistance in ovarian cancer: Identification and validation of biomarkers and targetable drivers of platinum resistance


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  High-risk human papillomaviruses (HPV) cause cervical, anogenital, and head and neck cancers. Despite the availability of preventive HPV vaccines, their poor uptake leaves most men and women at risk for these cancers, many of which remain common globally and others which are increasing domestically. Through direct mechanistic studies of viral and host protein partnerships, this project will uncover how cellular growth and differentiation are hijacked by HPV, and how cellular immortalization is temporally and longitudinally activated by HPV, all of which must occur for HPV-associated cancer development and progression.

PI_NAMEs: KATZENELLENBOGEN, RACHEL ADRIA (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;Automobile Driving;Binding Proteins;Biological Models;Cancer cell line;cancer initiation;cancer risk;cancer therapy;cancer type;Catalytic Domain;Cell Cycle Arrest;Cell Differentiation process;cell growth;Cell Line;Cell Physiology;Cells;cellular longevity;cellular targeting;Cervical;chronic infection;Chronology;Clinical;clinical risk;Collaborations;Cytoplasm;Data;Development;Differentiation and Growth;Disease;Etiology;Fostering;Future;Gene Targeting;Genetic Transcription;Genome;Goals;Growth;Head and Neck Cancer;high risk;High Risk Woman;HPV-High Risk;Human papilloma virus infection;human papilloma virus oncogene;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Infection;insight;Investigation;keratinocyte;Knock-out;Knowledge;Laboratories;Life Cycle Stages;Link;Longevity;Longitudinal Studies;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;men;Molecular;mutant;Oncogenic;Oncogenic Viruses;Oncoproteins;overexpression;Papillomavirus Transforming Protein E6;Pathway interactions;Poly(A)-Binding Proteins;posttranscriptional;prevent;Preventive;Preventive vaccine;protein function;protein protein interaction;Proteins;Regulation;Research;Risk;Risk Factors;senescence;Signal Transduction;Target Populations;Telomerase;TERT gene;therapeutic development;Therapeutic Intervention;Time;tumor progression;tumorigenesis;uptake;Viral;Viral Genes;Viral Markers;Viral Oncogene;Virus;Woman;Work

PROJECT_TITLE: High-risk HPV E6:  dysregulation of immortalization, growth, and differentiation through protein partnerships in HPV-associated cancers

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BAUMAN, LAURIE J (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adoption;AIDS prevention;Articulation;behavior change;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;behavioral study;Caring;clinical center;Clinical Research;cognitive interview;Collaborations;Communities;community collaboration;Consequences of HIV;Consultations;Data;Data Collection;design;Development;Emotional;Ensure;Epidemic;Equity;evidence base;Evidence based intervention;Faculty;Feedback;Future;Goals;Grant;Health;high risk population;HIV;HIV Infections;Hybrids;implementation design;implementation framework;implementation science;implementation strategy;improved;Infrastructure;Institution;Interest Group;lens;Logic;meetings;member;Mental disorders;Mental Health;Mentors;Methods;Modeling;next generation;Outcome;outreach program;Paper;Participant;Patients;prevent;Prevention;Process;programs;Provider;provider behavior;Publishing;Qualitative Methods;Qualitative Research;Reduce health disparities;Research;Research Design;Research Methodology;Research Personnel;research study;Resources;response;Risk Reduction;scale up;Services;Shapes;social;social science research;Social Sciences;Societies;Strategic Planning;Surveys;System;theories;tool;transmission process;trial design;United States National Institutes of Health;Universities


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed research will combine the expertise from data privacy, biomedical informatics, machine learning, and cloud computing to develop data outsourcing and sharing technologies for AI-powered Parkinson’s Disease research. The outcome is expected to have a broader impact beyond PD research in removing a major privacy roadblock that restricts medical data accessibility and in advancing the theory and implementation of cloud-based medical studies with data privacy protection.

PI_NAMEs: CHEN, SHIGANG  (contact);WU, SAMUEL S

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: accurate diagnosis;Artificial Intelligence;artificial neural network;Biomedical Computing;biomedical informatics;Biomedical Research;Classification;cloud based;Cloud Computing;cloud storage;Complex;Consumption;cost;Data;data privacy;Data Set;data sharing;deep learning;deep neural network;Diagnosis;digital technology;Disease;distributed data;encryption;experimental study;Foundations;Genetic;Hospitals;Image;improved;individualized medicine;Joint Prosthesis;Laws;learning network;Machine Learning;Masks;Mathematics;Medical;Methods;mobile computing;Modeling;Modernization;Neural Network Simulation;Non-linear Models;novel;operation;Outcome;Outsourcing;Parkinson Disease;Parkinsonian Disorders;Patient Data Privacy;Patients;Performance;Privacy;privacy preservation;privacy protection;Public Health Informatics;Quality of life;Randomized;Regulation;Research;Risk;Series;Source;Technology;Theoretical Studies;theories;Time;Training;Universities;Work

PROJECT_TITLE: SCH: Enabling Data Outsourcing and Sharing for AI-powered Parkinson's Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lupus;Racial and Ethnic Minority Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Substantial genetic and clinical differences exist between European-American (EA) and African-American (AA) systemic lupus erythematosus (SLE), and our mechanistic understanding of 1) the SLE epigenome and 2) how it impacts the disease’s clinical differences along racial lines remains woefully lacking. Our laboratory, therefore, has joined with the Buenrostro laboratory at Harvard to utilize their sciATAC-seq (single cell indexing assay for transposase-accessible chromatin) method to assess cell-specific chromatin accessibility differences between SLE cases and controls, and between EA and AA SLE cases. Utilizing our cutting-edge approach, we believe our planned Aims will significantly contribute to a better understanding of how the epigenome process genetic information from genotype to phenotype in a cell-, disease- and racially-specific manner, thereby significantly aiding in the translation of genetic knowledge into actionable clinical knowledge.

PI_NAMEs: GAFFNEY, PATRICK M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: African American;Age;Alleles;Allelic Imbalance;American;Antigens;Architecture;ATAC-seq;Autoantigens;Autoimmune Diseases;Automobile Driving;Biological Assay;case control;cell type;Cells;Cerebritis;Chromatin;Classification;Clinical;Clinical Data;clinical phenotype;clinically actionable;Collaborations;Control Groups;Cryopreservation;Data;data integration;Diagnosis;Disease;disorder risk;Disparity;Disparity in diagnosis;Doctor of Philosophy;Epigenetic Process;epigenetic regulation;epigenome;European;Exhibits;experience;Family-Based Registry;Feasibility Studies;Gene Expression;Genetic;genetic architecture;genetic information;Genetic Processes;Genetic study;Genetic Variation;Genome;genome-wide;Genomic Segment;Genotype;Goals;Histones;Human;Immune Tolerance;indexing;Inflammatory;innovation;Interferons;Investigation;Knowledge;Laboratories;Lupus;Methods;Molecular;mortality;Nephritis;Organ;Outcome;Pathogenesis;Patients;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;population based;Positioning Attribute;Process;programs;prototype;Quantitative Trait Loci;Race;racial difference;racial disparity;Regulatory Element;Reporter;repository;Research;Resources;response;Risk;risk variant;Role;Sampling;Self Tolerance;Shapes;single cell ATAC-seq;Single Nucleotide Polymorphism;success;Systemic Lupus Erythematosus;Technology;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;translational genetics;Transposase;Validation;Variant

PROJECT_TITLE: Disease and Race Specific Single-cell Epigenetic Mechanisms in Human SLE

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunotherapy;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BERMAN, JOAN WEINBERGER (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Animal Model;Anti-Retroviral Agents;Anti-viral Agents;antibody-dependent cell cytotoxicity;Antigens;antiretroviral therapy;Articulation;Biochemical;Bioinformatics;Biological Assay;Biological Markers;Biological Products;Biology;biomarker performance;Blood;Body Fluids;Brain;Cell Culture Techniques;Cell Separation;cell type;Cells;Cellular Immunity;Characteristics;Clinical;Clinical Sciences;Collaborations;comorbidity;Consultations;Development;DNA;Drug Kinetics;Effectiveness;Enzyme-Linked Immunosorbent Assay;Epidemic;experience;forging;Freezing;Future;Goals;HIV;HIV Infections;HIV risk;HIV/AIDS;Human;Humoral Immunities;Immune;Immunotherapy;implementation research;improved;In Vitro;in vivo;Infrastructure;innovative technologies;Insecta;Institution;Knowledge;Leadership;Life Cycle Stages;Ligands;Link;Liquid substance;Macrophage;Mass Spectrum Analysis;Measurement;medication compliance;member;Mental Health;Mentors;Mentorship;metabolomics;microbiome analysis;Modeling;monocyte;new technology;next generation;novel;novel strategies;Participant;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacodynamics;pre-exposure prophylaxis;prevent;Prevention approach;Process;Production;programs;Prophylactic treatment;Proteins;Proteomics;Reagent;receptor;recruit;Research;Research Personnel;Resources;response;Risk;RNA;Sampling;Science;Services;small molecule;synergism;Technology;Therapeutic;therapy adherence;tissue culture;Training;transcriptomics;Translational Research;treatment as prevention;Vaccines;Viral;Virus;working group


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE The purpose of this project is to identify the structure and provisions of Severe Emotional Disturbance (SED) 1915(c) HCBS waiver programs across the United States, the characteristics of children served in these programs and the extent to which they are at risk of psychiatric long-term care (LTC) placement, and estimate the effects of an SED waiver on behavioral health care service use and expenditures for children with SED. Because these policies aim to reduce the use of psychiatric LTC through the provision of community-based alternatives—but programs and environments vary considerably across states and over time—this study will explicitly examine variation in program structures and participants and will assess policy impacts on community-based and out-of-community service use and expenditures, while accounting for contextual variation. As this study relies on data drawn from state administrative documents and public healthcare claims, this grant also provides training in research design and statistical methods for utilizing policy and claims data to address key information needs for behavioral health policy decision-making that reduces avoidable use of psychiatric LTC.

PI_NAMEs: GRAAF, GENEVIEVE  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Achievement;Address;Administrator;alternative treatment;Americans with Disabilities Act;behavior measurement;behavioral health;Caring;Characteristics;Child;Child Care;Clinical;Communities;community based service;Community Services;Complex;cost;Data;Data Analyses;Data Collection;data management;Data Reporting;Data Set;Decision Making;Diagnosis;Disease;Distress;Effectiveness;Enrollment;Environment;Exhibits;Expenditure;experience;Family;Financial Hardship;functional improvement;Funding;Goals;Grant;Health;health care service utilization;Health financing;Health Policy;health service use;Healthcare;Home;Home Ranges;Improve Access;improved;Income;Individual;Institution;Instruction;Intervention;Knowledge;Knowledge acquisition;Laws;Long-Term Care;Maps;Medicaid;Medicaid services;Mentors;Mentorship;Methodology;Modeling;National Institute of Mental Health;non-compliance;novel;Outcome;Parents;Participant;patient home care;Policies;Policy Maker;prevent;programs;Provider;psychiatric inpatient;Psychiatric therapeutic procedure;Public Health;Research;Research Design;Research Methodology;Research Personnel;residential care facility;Residential Treatment;Resources;Risk;Risk Factors;Risk Reduction;serious emotional disturbance;service intervention;service utilization;Services;Severities;skills;Source;Statistical Methods;statistics;Strategic Planning;Structure;symposium;Symptoms;System;Techniques;Texas;Time;Time Study;Training;training opportunity;United States;Variant;waiver;Writing;Youth

PROJECT_TITLE: Assessing the impacts of Medicaid Home and Community Based Waivers for children with Severe Emotional Disturbance

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative The studies proposed here will further elucidate subcellular mechanisms of single neuron computation. The results will provide detailed insights into postsynaptic mechanisms for input processing that allow for flexible toggling among different outputs in individual neurons. The findings from the study will not only contribute to our basic understanding of the computational capacity of the brain but will also aid in our understanding of subcellular dysfunctions in neurological diseases.

PI_NAMEs: SMITH, IKUKO  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acceleration;Action Potentials;Address;Affect;Alzheimer's Disease;Animals;awake;Axon;Brain;Calcium;calcium indicator;Code;Coupled;Data;Dendrites;Dendritic Spines;Disease;Distal;efficacy evaluation;Electrophysiology (science);Event;Exhibits;Fire - disasters;flexibility;Frequencies;Functional disorder;Generations;hippocampal pyramidal neuron;Image;In Vitro;in vivo;Individual;information processing;inhibitory neuron;Injections;insight;Knowledge;Lead;Location;Maps;Measurement;Mus;Nature;Nervous System Disorder;neural circuit;neuronal cell body;Neurons;neurophysiology;neurotrophic factor;optogenetics;Output;Parents;patch clamp;Play;postsynaptic;Process;Property;receptive field;regenerative;Reporting;response;Role;Sensory;sensory integration;signal processing;Signal Transduction;Site;Sodium;Somatostatin;Spatial Distribution;Synapses;Techniques;Testing;two-photon;Vertebral column;Visual Cortex;voltage;Whole-Cell Recordings

PROJECT_TITLE: Elucidating mechanisms of active dendritic integration in vivo

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

PI_NAMEs: ANASTOS, KATHRYN M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;African American;AIDS prevention;Area;Behavioral;biobank;Biometry;brain magnetic resonance imaging;cardiac magnetic resonance imaging;Caring;Characteristics;Cities;Clinical;Clinical and Translational Science Awards;clinical database;Clinical effectiveness;clinical infrastructure;Clinical Research;Clinical Sciences;Clinical Services;Clinical Trials;cohort;Cohort Studies;Collaborations;Color;Community Health;Conduct Clinical Trials;Consent;Consultations;contextual factors;COVID-19;Creativeness;Data;Data Analyses;data infrastructure;Databases;Development;Discipline;Electronic Health Record;Enrollment;Epidemic;Epidemiology;experience;Explosion;Fertilization;Fostering;Funding;Genetic;Goals;Health;health care service utilization;health data;Health Services;Health Services Accessibility;Health system;Heterosexuals;high risk;Hispanic;HIV;HIV Infections;HIV Seronegativity;Human;Immunologics;implementation science;improved;Individual;Informatics;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intervention;Investigation;Latinx;Leukapheresis;Link;Logistics;longitudinal database;Machine Learning;men who have sex with men;Mental Health;Methods;Migrant;Mission;Natural Language Processing;New York;New York City;novel;operation;Outcome;Participant;participant enrollment;patient population;Patient Recruitments;Patients;Persons;Phenotype;Policies;Population;Population Heterogeneity;pre-exposure prophylaxis;Pregnancy;Pregnant Women;prevent;Prevention;prevention service;Primary Prevention;Procedures;programs;prospective;Prospective Studies;Protocols documentation;Provider;Public Health;recruit;repository;Research;Research Activity;Research Design;Research Personnel;research study;Research Support;Resources;Retrospective Studies;sample collection;Science;Scientist;Services;Shipping;Source;Specific qualifier value;Specimen;substance user;Support System;System;transgender;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Universities;Update;Vision;Woman;Work;working group


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative  The goal of this study is to employ Bayesian inference to design subject-specific models of voice production for norm and structural vocal pathologies. The proposed models utilize high-speed videoendoscopy, electroglottography, and acoustic data for parameter inference and model validation. The vocal dynamics, glottal aerodynamics and their interactions are studied comprehensively using the computational models to better understand the normal and disordered function of voice.

PI_NAMEs: NAGHIBOLHOSSEINI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Air Movements;Area;Award;Bayesian Analysis;Bayesian Modeling;Bayesian Prediction;Behavior;Biomechanics;Biophysical Process;Characteristics;Communication;Complex;Computer Models;Coupled;Coupling;Data;design;Diagnosis;Disease;Edema;efficacy evaluation;Elements;Functional disorder;Future;Goals;Health;Human;human data;Hybrids;improved;in vivo;Individual;kinematics;Kinetics;Knowledge;Laryngitis;Larynx;Liquid substance;Lung;Measurement;Methods;model design;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;Noise;Normal Range;novel strategies;Operative Surgical Procedures;Oral cavity;Outcome;Outcome Study;Outcomes Research;Parameter Estimation;Participant;Pathologic;Pathology;Patients;Pattern;Phonation;Polyps;predictive modeling;Prevention;Probability;Production;Property;Research;Research Personnel;Signal Transduction;simulation;Speed;Strategic Planning;Structure;System;Techniques;Tissues;tool;Treatment Efficacy;Uncertainty;Validation;vibration;vocal cord;Voice;Voice Disorders

PROJECT_TITLE: Bayesian Data-Driven Subject-Specific Modeling of Voice Production

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The purpose of the proposed program is to continue a training program at the Institute of Child Development (ICD) that has been supported by NIMH since 1959 and that in 1981 added postdoctoral trainees. Its goal is to train the next generation of scholars in developmental psychopathology who will conduct multiple levels of analysis and interdisciplinary research addressing of NIMH’s strategic objectives. Consistent with the fourth strategic objective, our trainees gain experience in community engagement and translation of research findings to practical application.

PI_NAMEs: GUNNAR, MEGAN R (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Development;Psychopathology

PROJECT_TITLE: Developmental Psychopathology


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Depression;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: GABBAY, VILMA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;antiretroviral therapy;Anxiety;Area;Behavioral;Biological Markers;Brain;burden of illness;Caring;Clinical;clinical translation;Code;Cognition;cognitive neuroscience;cohort;Collaborations;Communities;comorbidity;Data;Databases;Depressive disorder;Diagnosis;Diagnostic;Enrollment;Epidemic;Epidemiology;experience;Fostering;Funding;Future;Goals;Group Meetings;Health;health disparity;Health system;HIV;HIV/AIDS;Immunology;implementation science;improved;Inflammation;Institution;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Investigation;Knowledge;member;Mental Depression;Mental disorders;Mental Health;Mission;multidisciplinary;National Institute of Drug Abuse;National Institute of Mental Health;neural circuit;neurochemistry;neuroimaging;Neuroimmune;neuroinflammation;Neurology;neuropsychiatry;New York City;novel;Outcome;Pain;Pathway interactions;Persons;pre-clinical;Prevalence;psychiatric comorbidity;Public Health;recruit;Research;Research Personnel;Research Project Grants;Resources;Risk;scientific organization;substance use;Substance Use Disorder;Technology;Translational Research;transmission process;Universities;Work;working group


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Wound healing is markedly impaired by diabetes, which is caused in part by alterations in the subpopulations of cells important for tissue repair. It is our fundamental hypothesis that restoration of those cellular populations can reverse these defects and correct wound healing and other diabetic complications. In this proposal, we will use emerging single cell techniques to identify the critical alterations in cellular populations induced by diabetes in mice and humans and use these insights to develop cell based strategies to restore these depleted populations to prevent diabetic complications.

PI_NAMEs: GURTNER, GEOFFREY C (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Animal Model;Behavior;Biological Assay;cell behavior;Cell Line;Cell Therapy;Cells;Chronic;Clinical;Complications of Diabetes Mellitus;cytokine;Data;Debridement;Defect;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Disease Progression;disorder control;Ecology;Evaluation;Functional disorder;Funding;Gene Expression;Gene Expression Profile;healing;heart disease risk;Homing;Human;Hyperglycemia;Hypertension;Hypoglycemic Agents;Impairment;improved;In Vitro;Individual;insight;Insulin;interest;intravenous administration;Ischemia;Laboratories;limb amputation;Location;Lower Extremity;Medical;Methodology;Methods;Molecular;mouse model;multimodality;Mus;Muscle;neovascularization;next generation;non-diabetic;non-healing wounds;novel;novel strategies;novel therapeutic intervention;Oligonucleotides;Oral;Organ;Pathogenesis;Pathway interactions;Patients;Physiological;Population;Population Dynamics;prevent;Process;Production;protein expression;Proteomics;reparative process;Resolution;response;restoration;Role;Sampling;single cell sequencing;single-cell RNA sequencing;Sorting;stem cells;Stroke;Techniques;Technology;Therapeutic Uses;Time;tissue repair;Tissues;transcriptome;transcriptomics;United States;United States National Institutes of Health;Vascular System;Visit;wasting;Work;wound;wound environment;wound healing

PROJECT_TITLE: Correcting the Cellular Ecology of Diabetic Complications

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE This research program on the Demography of Chronic Pain enhances U.S. public health by documenting population-level patterns and trends in chronic pain, identifying individual-level and contextual factors that could reduce the burden of pain and disparities therein, and clarifying how pain contributes to U.S. disability and mortality. We leverage large-scale, longitudinal data from the U.S. and from peer countries to conduct comparative, policy-relevant research. This project investigates pain both as a public health problem in its own right, and as a potential missing link in understanding recent adverse trends in U.S. health disparities, disability, and mortality.

PI_NAMEs: GROL-PROKOPCZYK, HANNA  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adult;Age;age group;Aging;aging population;American;Attention;Behavioral;Cessation of life;Characteristics;chronic pain;comparative;contextual factors;cost;Country;Data;Data Set;Demographer;Demography;Development;disability;Disablement;Disabling;Disparity;Education;Empirical Research;European;experience;Exposure to;Goals;Health;health disparity;health inequalities;Health Policy;Health system;Health trends;healthy aging;High Prevalence;high risk;Incidence;Individual;Industrialization;innovation;Investigation;Knowledge;knowledge base;Life Cycle Stages;Link;Longitudinal trends;Low income;Measurement;Measures;Medical;Methodology;Methods;middle age;Modeling;mortality;multilevel analysis;neglect;Opioid Analgesics;opioid epidemic;Outcome;Pain;Pain management;pain patient;Pain Research;pain-related disability;Pathway interactions;Pattern;peer;Personal Satisfaction;Policies;Population;population health;Prevalence;prevent;Process;programs;psychologic;psychosocial;Public Health;Research;Research Personnel;Research Priority;Role;Shapes;social;social disparities;sociodemographic group;socioeconomics;suicide rate;theories;Therapeutic;Time trend;tool;trend;virtual;Work

PROJECT_TITLE: The Demography of Chronic Pain: A Population Approach to Pain Trends, Pain Disparities, and Pain-Related Disability and Death

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Narrative: Post-Baccalaureate Training in Biomedical Research This research education program will provide 1 or 2 years of support and professional skills development for recent college graduates. The goal is to help students from diverse backgrounds (e.g. ethnic/racial minorities, individuals with disabilities, and individuals from disadvantaged backgrounds) to advance to successful biomedical research careers at the PhD level, thus contributing to the diversification of the biomedical research workforce.

PI_NAMEs: LUJAN, LUIS ;MAHER, LOUIS JAMES (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Accountability;Address;Adopted;Advisory Committees;Assessment tool;Basic Science;Biomedical Research;bridge program;career;Career Choice;career networking;Climacteric;Clinic;cohort;college;Critical Thinking;Data;Development;Development Plans;Disabled Persons;disadvantaged background;Disparity population;Doctor of Philosophy;Doctor's Degree;education planning;education research;Educational Activities;Educational Curriculum;Educational process of instructing;Elements;Ensure;Environment;Ethnic Origin;experience;Exposure to;Faculty;follow-up;Fostering;Funding;Goals;graduate school;graduate student;Health;high school;High School Student;improved;Individual;Industry;innovation;Institution;junior high school;Laboratories;Laws;Leadership;leadership development;matriculation;meetings;member;Mentors;Mentorship;Outcome;Pathway interactions;patient population;Personality;Postbaccalaureate;Program Evaluation;programs;racial minority;recruit;Research;Resources;Science;Science Policy;Self Assessment;skill acquisition;skills;social;Structure;Students;success;Surveys;symposium;tool;Training;Training Programs;Translational Research;translational research program;tutoring;undergraduate research;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Work;Writing

PROJECT_TITLE: Post-baccalaureate Training in Biomedical Research

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it represents an innovative multi-level approach to identifying targets for effective interventions to improve the quality of care for older adults with Alzheimer's Disease and Related Dementias and limited-English proficiency through improved palliative care. These results will enable the identification and prioritization of modifiable factors to inform effective and scalable strategies to facilitate goal-concordant care for this vulnerable population. The proposed research addresses the NIA's mission to eliminate disparities and improve the well-being of older adults with Alzheimer's Disease and Related Dementias and their family caregivers.

PI_NAMEs: SHARMA, RASHMI K. (contact)

PROJECT_TERMS: Address;Administrator;advanced dementia;Age;Alzheimer's disease related dementia;Caring;Cessation of life;Chinese;Communication;Communities;community engagement;community organizations;culturally appropriate intervention;Data;Dementia;Development;Diagnosis;disparity elimination;Documentation;Education;effective intervention;Electronic Health Record;end of life;end of life care;Evaluation;experience;Face;Family;Family Caregiver;Family member;Future;Gender;Goals;health inequalities;Health system;Healthcare;high risk;improved;Inequity;Infrastructure;innovation;Intervention;Interview;Knowledge;Language;Latinx;Limited English Proficiency;Linguistics;machine learning method;Mediator;Methods;Mission;Modeling;multidisciplinary;Natural Language Processing;novel;older adult;Outcome;Palliative Care;Patients;Personal Satisfaction;Persons;Population;preference;Prognosis;provider communication;Public Health;Qualitative Methods;Quality of Care;Quality of life;Reporting;Research;Research Personnel;Resources;sociodemographic factors;Structure;symptom management;Symptoms;System;Testing;therapy development;Vietnamese;Vulnerable Populations;Work

PROJECT_TITLE: Understanding and Improving Inequities in Palliative Care for Older Adults with Advanced Dementia and Limited-English Proficiency: A Mixed-Methods Evaluation

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: In this grant application, we propose to study the biological functions of transcription coactivator in advanced and treatment-refractory prostate cancer. As such, the studies proposed here will lead to the identification of novel signaling components that facilitate transcription addiction and will offer novel therapies in treating prostate cancer.

PI_NAMEs: ASANGANI, IRFAN AHMED (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: abiraterone;addiction;Address;advanced prostate cancer;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Anti-androgen Therapy;anti-cancer research;Applications Grants;Attenuated;Biological Process;cell growth;Cell Line;Cells;Cessation of life;ChIP-seq;Chromatin;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;Death Rate;Development;Disease;Disease Progression;Disease Resistance;Drug resistance;Engineering;Enhancers;enzalutamide;Event;Foundations;Generations;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Goals;Growth;improved;in vivo Model;ineffective therapies;inhibitor;knock-down;Knock-in;Knowledge;Ligands;Link;Malignant neoplasm of prostate;Mediating;Mediator;Metastatic Prostate Cancer;Methods;Molecular;Morbidity - disease rate;mortality;Mus;mutant;novel;novel strategies;novel therapeutics;Nuclear Receptors;Oncogenic;Oral;Outcome;patient derived xenograft model;patient population;Patients;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Population;potential biomarker;Prognostic Marker;programs;Prostate;prostate cancer cell;prostate cancer model;Receptor Signaling;Refractory;Refractory Disease;Research Design;Resistance;Resistance development;RNA Polymerase II;Role;Sampling;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;small molecule inhibitor;Solid;standard of care;success;System;Testing;therapeutic target;therapy resistant;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumor;United States

PROJECT_TITLE: Role of MED1 in the AR-dependent transcription in advanced prostate cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Immunotherapy with immune checkpoint inhibitors (ICIs) for advanced bladder cancer is only moderately effective, costly, inconveniently administrated through intravenous infusion and associated with significant immune-mediated toxicity secondary to delivery of ICIs to and activation of immune response against non-cancerous tissues. The goal of this project is to develop an oral, more effective, less toxic, more affordable immunotherapy medication that can also be used for photodynamic diagnosis and therapy of bladder cancer.

PI_NAMEs: PAN, CHONG-XIAN  (contact)

PROJECT_TERMS: Abscopal effect;Animals;anti-cancer;ARID1A gene;Attenuated;Autophagocytosis;Award;Basic Science;Bioinformatics;Bladder;cancer cell;Cancer Etiology;cancer immunotherapy;cancer site;Caring;Cause of Death;Cell Culture Techniques;Cessation of life;Chemoresistance;chemotherapy;Clinical;Clinical Trials;Combination immunotherapy;Combination Medication;comparative efficacy;Consultations;cost;Cytotoxic Chemotherapy;design;Development;Diagnosis;Diagnostic;Disseminated Malignant Neoplasm;efficacy evaluation;efficacy study;Fluorescence;Genes;Goals;Health;Home;Human;Immune;immune activation;Immune checkpoint inhibitor;immune clearance;Immune response;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Intravenous;Intravenous infusion procedures;Legal patent;Licensing;Life;Light;Liver;Maintenance;male;malignant mouth neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Medical;Medical Oncology;men;Modality;Modeling;Mus;Names;Neoplasm Metastasis;Normal tissue morphology;novel;Operative Surgical Procedures;Oral;Oral Administration;oral immunotherapy;Organ;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Photosensitizing Agents;PIK3CG gene;Plants;prevent;Prognosis;Proteins;PUVA Photochemotherapy;Quality of life;Radical Cystectomy;Reactive Oxygen Species;red fluorescent protein;Regimen;Research;Research Project Grants;Resistance;response;Safety;Salmonella;Secondary to;Services;Surface;systemic toxicity;targeted treatment;theranostics;Therapeutic;Tissues;Toxic effect;Transgenic Mice;Translating;Translational Research;Treatment outcome;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States Department of Agriculture;United States Food and Drug Administration;Urology;vector vaccine;Veterans;Work

PROJECT_TITLE: BCCMA: Translational research to improve the care of advanced bladder cancer


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Narrative Cisplatin and other platinum-based chemotherapeutic drugs are still the mainstay treatment for many cancers. Clinical limitations, however, including cancer drug resistance, are a major health concern. The goal of this proposal is to assess the mechanism of how APOBEC3 deaminases activate BER and MMR to mediate cisplatin efficacy. Understanding the interplay between these pathways will help identify patients that will respond better to cisplatin chemotherapy as well as assist in the design of new treatment protocols in cancers.

PI_NAMEs: PATRICK, STEVE M (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Affect;analog;Antineoplastic Agents;Apoptosis;base;Base Excision Repairs;cancer drug resistance;Cancer Patient;cancer therapy;Carboplatin;Cell Line;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;cisplatin-DNA adduct;Clinical;Clinical Data;clinically relevant;crosslink;Cytidine Deaminase;Cytosine;Data;Deaminase;Deamination;Dependence;design;Development;DNA;DNA Adducts;DNA biosynthesis;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Inhibition;DNA Repair Pathway;DNA-(apurinic or apyrimidinic site) lyase;drug efficacy;Drug resistance;drug resistance development;Drug toxicity;Enzymes;Excision;Family;Family member;Generations;Goals;Health;homologous recombination;Hypersensitivity;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mediator;member;Mismatch Repair;Modeling;Mutation;Normal Cell;novel;Nucleotide Excision Repair;Nucleotides;Pathway interactions;patient response;patient stratification;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;phosphodiester;Platinum;Play;Polymerase;Process;Productivity;Protein Family;Protein Overexpression;Proteins;recruit;Resistance;response;Role;Sales;Sampling;Site;Structure;Testing;Therapeutic;Treatment Protocols;treatment response;tumor;Uracil;uracil-DNA glycosylase;Vertebral column;Work

PROJECT_TITLE: Novel role of APOBEC3 enzymes as key mediators of cisplatin sensitivity through aberrant processing of interstrand crosslinks


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Nerve-sparing radical prostatectomy is first line therapy for localized prostate cancer, however preservation of the surrounding nerve tissue continues to challenge surgeons and leaves up to 60% of patients with some form of incontinence and impotence post-surgery. Nerve visualization in the operating room is difficult and no clinically approved imaging methodology has been developed to aid in nerve identification and visualization. In the work proposed herein, we will develop a clinically relevant near infrared nerve-specific imaging strategy to be utilized with the FDA approved fluorescence-imaging channel in the da Vinci surgical robot enabling nerve-specific imaging during robotic assisted nerve-sparing radical prostatectomy for improved surgical outcomes.

PI_NAMEs: GIBBS, SUMMER LYNNE (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Adverse effects;Autopsy;Biodistribution;Biological;Blood-Nerve Barrier;canine model;Canis familiaris;chromophore;Clinical;Clinical Medicine;clinical translation;clinically relevant;design;Development;Dose;Dose Limiting;Drug Kinetics;falls;Family suidae;FDA approved;Fireflies;Fluorescence;fluorescence imaging;fluorescence-guided surgery;fluorophore;Formulation;Fright;Future;Goals;high resolution imaging;Hour;Human;Iatrogenesis;Image;Impotence;improved;Incontinence;Indocyanine Green;Infrastructure;Intuition;Knowledge;Lead;Light;Local Therapy;Malignant neoplasm of prostate;Methodology;Methylene blue;Modeling;Molecular Weight;Morbidity - disease rate;Nerve;nerve damage;nerve injury;Nerve Tissue;Nerve-Sparing Prostatectomy;Neuroanatomy;neurotransmission;novel;Operating Rooms;Operative Surgical Procedures;Optics;Patients;Pharmacodynamics;Pharmacology and Toxicology;Photoaffinity Labels;porcine model;pre-clinical;preservation;Property;Prostate;Prostatectomy;Prostatic;Proteomics;Radical Prostatectomy;Reporting;Robot;robotic system;Robotics;Rodent;small molecule;spared nerve;Specificity;Stains;Structure-Activity Relationship;Surgeon;surgery outcome;Surgical complication;Surgical Specialties;System;Technology;Testing;Tissues;Toxic effect;Toxicology;Translating;Translations;United States;Validation;Visualization;Work;Zebrafish

PROJECT_TITLE: Nerve-Specific Fluorophores for Improved Nerve Sparing during Prostatectomy using the Clinical Fluorescence Guided Surgery Infrastructure


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Microbiome;Organ Transplantation;Orphan Drug;Rare Diseases;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Intestinal transplantation (ITx) is the only therapeutic option for patients with intestinal failure once parenteral nutrition fails, but its use is limited by high rates of rejection that necessitate increased levels of immunosuppression, predisposing patients to infections, malignancy, and graft-versus-host disease. Previous work has demonstrated that rejection is mitigated by higher ratios of graft-versus-host (GVH)-reactive donor T cells in the graft relative to host-versus-graft (HVG)-reactive recipient T cells, but the factors that help determine the GVH:HVG balance remain unknown. Based on evidence that dysbiosis is associated with various states of gut inflammation including infection, inflammatory bowel disease, GVHD, and rejection, this proposal aims to identify novel biomarkers and treatments for rejection by exploring the hypothesis that homeostasis between the gut microbiome and mucosal defenses plays an essential role in maintaining the balance of GVH:HVG-reactive T cells in the graft, thus regulating rejection.

PI_NAMEs: WEINER, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Alloantigen;Allografting;analytical method;anti-microbial peptide;Antigen-Presenting Cells;Area;Attenuated;Bacteria;Blood;Bone Marrow;career;career development;Cells;Chimerism;Clinical;Clone Cells;commensal microbes;cross reactivity;Data;Department chair;Discipline;Disease;dysbiosis;Engraftment;Equilibrium;experience;Failure;fecal transplantation;Functional disorder;Funding;fungus;gastrointestinal transplantation;Goals;Graft Rejection;graft vs host disease;Growth;gut inflammation;gut microbes;gut microbiome;Gut Mucosa;Homeostasis;Host Defense;host microbiome;Human;Immersion;Immune;Immunobiology;Immunosuppression;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestines;Longitudinal Studies;Malignant Neoplasms;Mentors;Mentorship;Microbe;microbial;Microbiology;microbiome;microbiome analysis;microorganism antigen;migration;Mucous Membrane;novel;novel marker;novel therapeutics;Paneth Cells;Parenteral Nutrition;pathogenic microbe;Patients;Play;preservation;programs;Qualifying;Research;Research Personnel;residence;Resources;response;Role;Scientist;side effect;Surgeon;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Time;Translating;Transplant Recipients;Transplant Surgeon;Transplantation;Transplantation Immunology;Virus;Volatile Fatty Acids;Work

PROJECT_TITLE: Defining the relationship between host-microbiome interactions and rejection after intestinal transplantation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Clinical Research;Lung

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Laryngotracheal stenosis (obstructing scar in the larynx and trachea) occurs in patients after long-term breathing tube placement and can result in communication disability and high mortality rates due to the obstructed airway. This proposal will investigate the mechanism of how mTOR suppression works on the pathologic T-cell and fibroblast subsets that are critical to the development of iLTS. Finally, the proposal will test a novel drug eluting stent to deliver mTOR suppression directly to the site of disease in the larynx and trachea to target diseased T- cells and fibroblasts without side effects of systemic mTOR inhibition. !

PI_NAMEs: HILLEL, ALEXANDER  (contact)

PROJECT_TERMS: Airway Disease;airway obstruction;Attenuated;Autologous;Biocompatible Materials;Biological Models;Breathing;CD4 Positive T Lymphocytes;Cell Communication;cell growth;Cells;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cicatrix;clinical practice;Clinical Trials;Coculture Techniques;Collaborations;Collagen;Communication Disability;Coronary;cost;cytokine;Data;Death Rate;Dedications;design;Development;Diabetes Mellitus;Disease;druggable target;Dysphonia;efficacy evaluation;Engineering;Faculty;FDA approved;Fibroblasts;Fibrosis;Flow Cytometry;FOXP3 gene;FRAP1 gene;Funding;Gene Expression;Head and Neck Surgery;Histopathology;Homeostasis;Human;Iatrogenesis;Immune;improved;In Vitro;in vivo;in vivo Model;Individual;Intubation;Laboratories;Laryngeal Diseases;Larynx;Mediating;Medical;medical schools;member;Metabolic;Metabolism;Methods;mouse model;mTOR inhibition;mTOR Inhibitor;mTOR protein;Mus;National Institute on Deafness and Other Communication Disorders;novel;novel strategies;novel therapeutics;Otolaryngology;Pathogenesis;Pathologic;Pathologic Processes;Patient Participation;Patients;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Population;pre-clinical;prevent;Proliferating;Regenerative Medicine;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Research Project Grants;restenosis;Role;Scientist;side effect;single cell mRNA sequencing;single cell sequencing;Sirolimus;Site;Sorting;Specimen;Stenosis;Stents;Surgical Management;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic Effect;Trachea;Tracheostomy procedure;translation to humans;Tube;Validation;Work;wound healing

PROJECT_TITLE: Targeting mTOR regulation of T-lymphocytes and fibroblasts in Laryngotracheal Stenosis

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Medicare is a critical and highly popular program for the elderly and disabled that protects both their financial security and access to care. Successful innovation in provider payment, of the types studied in this proposal, is necessary to enhance the benefits of the Medicare program for patients.

PI_NAMEs: LANDON, BRUCE E. (contact);MCWILLIAMS, JOHN MICHAEL

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Accountability;accountable care organization;Adoption;Affect;Area;Automobile Driving;Award;beneficiary;cancer care;care delivery;Caring;comparative;Contracts;Data;Data Sources;Dementia;design;disabled;Disparity;Elderly;Elements;Empirical Research;Enrollment;evidence base;Evolution;experience;Failure;flexibility;Goals;Health;health plan;Health Services Accessibility;Healthcare;Healthcare Systems;improved;Incentives;Individual;innovation;insight;intrinsic motivation;Leadership;Learning;Link;Managed Care;Measures;Medicaid;Medicare;Medicare/Medicaid;Methodology;Methods;Modeling;Monitor;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Patterns of Care;payment;Performance;Personal Satisfaction;Physicians;Policies;Positioning Attribute;Privatization;Program Research Project Grants;programs;prospective;Provider;provider networks;Quality of Care;Quasi-experiment;Replacement Arthroplasty;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Risk;Risk Adjustment;Savings;Security;Shapes;sound;Special needs;System;Talents;Techniques;Translating;Update;Variant;wasting;Work

PROJECT_TITLE: Improving Medicare in an Era of Change


NIH_SPENDING_CATS: Aging

PI_NAMEs: LANDON, BRUCE E. (contact)

PROJECT_TERMS: Achievement;Agreement;Amendment;Budgets;Certification;Communication;Communities;Complex;Computer Hardware;Computer software;Computers;Critiques;Data;data handling;Data Sources;Documentation;driving force;Ensure;Equipment;Evaluation;Funding;Funding Agency;Goals;Grant;Health Policy;Human Resources;human subject;improved;Institution;Institutional Review Boards;Lead;Leadership;Logistics;Maintenance;Mediation;medical schools;Medicare;meetings;member;Methods;Mission;Modification;Monitor;Newsletter;operation;Performance;Persons;Postdoctoral Fellow;Principal Investigator;programs;Progress Reports;Protocols documentation;Publications;Recording of previous events;Records;recruit;Research;Research Personnel;Research Project Grants;Secure;Security;Services;Structure;Students;symposium;Telephone;Time;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Defining the Impact of Initial Influenza Exposure on Immunity in Infants Establishment of a maternal-infant cohort in Cincinnati and Mexico City to detect influenza infection and vaccination will provide the framework to improve our understanding of the immunological responses to the initial infant influenza exposure, be it infection or vaccine, and how that initial exposure imprints the infant’s response to subsequent exposures. The information gained from the Influenza IMPRINT Cohort and the planned analyses will provide the knowledge needed to develop an effective universal influenza vaccine. Our instructive maternal-infant cohort will investigate unique features of how individuals immunologically respond to natural infection compared with vaccination, and the potential impact of vertically transferred maternal immunity. Longitudinal evaluation of these individuals will establish how prior influenza exposure impacts susceptibility and the immune response to infection by genetically identical, similar or discordant influenza virus strains that draws a blueprint for more universal influenza vaccines strategies.

PI_NAMEs: STAAT, MARY A (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Antibodies;Antigens;B-Lymphocytes;Blood;Breast Feeding;Child;Childhood;Cities;Clinical;cohort;Collection;Communicable Diseases;Effectiveness;Enrollment;Epidemiology;Epitopes;Evaluation;Exposure to;Frequencies;Future;Genetic Programming;Genetic Variation;Goals;Human;Immune;Immune response;Immunity;Immunization;Immunologic Memory;Immunologics;Immunology;imprint;improved;Individual;infancy;Infant;Infection;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;Infrastructure;Knowledge;late life;Life;Maintenance;Maternally-Acquired Immunity;Memory;Mexico;Milk;Mothers;nasal swab;Nature;Pediatric Hospitals;Population;postnatal;Predisposition;Pregnant Women;Primary Infection;recruit;Reporting;Research Personnel;response;Sampling;Schedule;seasonal influenza;Seasons;secondary infection;Shapes;Site;stem;Symptoms;T memory cell;T-Lymphocyte;Umbilical Cord Blood;universal influenza vaccine;Vaccination;vaccine strategy;Vaccines;Variant;Viral;Viral Antigens;virology;Virus;virus genetics

PROJECT_TITLE: Impact of the Initial Influenza Exposure on the Quality, Magnitude, Breadth, Potency and Durability of Influenza Immunity


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

PI_NAMEs: HATFIELD, LAURA  (contact)

PROJECT_TERMS: Address;Agreement;analytical method;archive data;Area;Budgets;Categories;Clinical;Code;comorbidity;comparison group;complex data;Control Groups;cost effective;Data;Data Analyses;Data Linkages;data management;data privacy;data resource;Data Set;Data Sources;design;Development;Diagnosis;Economic Models;Economics;Eligibility Determination;Enrollment;Ensure;Exclusion;experience;Faculty;Federal Government;Geography;Goals;Health;Health Insurance;Healthcare;improved;Individual;Institutional Review Boards;intergenerational;Knowledge;Leadership;Link;Managed Care;Measures;Medicaid;Medicare;Medicare/Medicaid;member;Mentors;Methodology;Methods;Modeling;novel;Observational Study;older adult;Outcome;Persons;Policies;Procedures;Process;programs;Protocols documentation;Provider;Quasi-experiment;Research;Research Methodology;Research Personnel;Resources;Risk Adjustment;Role;Sampling;Scientific Advances and Accomplishments;Secure;Security;Services;Specific qualifier value;Standardization;Statistical Methods;statistics;Structure;Surveys;task analysis;Technical Expertise;Techniques;theories;validation studies;welfare;Work

PROJECT_TITLE: Data And Methods Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Heart failure is a leading cause of morbidity and mortality in the United States and worldwide and results in a tremendous healthcare burden. Identifying and characterizing novel therapeutic targets is critical due to few recent discoveries being translated into effective therapies. This proposal will investigate the role of a previously unstudied ligand/receptor system, TRAIL/DR5 in the heart, which has been identified in human studies as being a powerful predictor of heart failure risk and progression severity, in order to define its role and gain insight into a potential novel therapeutic target.

PI_NAMEs: GRISANTI, LAUREL ANN (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Agonist;Antibodies;aorta constriction;Apoptosis;cancer cell;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Caspase;Cell Death;cell type;Cells;Cessation of life;Characteristics;Clinical;Clinical Research;Clinical Trials;clinically relevant;Development;effective therapy;Epidermal Growth Factor Receptor;Excision;field study;Genetic;Growth;healthcare burden;Heart;Heart Diseases;Heart failure;heart function;Human;Hypertrophy;Immune;improved;In Vitro;in vivo;Individual;Induction of Apoptosis;insight;Ischemia;Knock-out;Knockout Mice;Laboratories;Ligand Binding;Ligands;Malignant Neoplasms;MAPK3 gene;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;Neonatal;new therapeutic target;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Play;Population;predictive marker;prevent;Proliferating;Proteins;Publishing;Rattus;receptor;Receptor Activation;receptor expression;Receptor Signaling;repaired;Reperfusion Therapy;Reporting;Research Proposals;Risk;Risk Marker;Rodent;Role;Severities;Signal Pathway;Signal Transduction;Signal Transduction Inhibitor;Signal Transduction Pathway;small molecule;Stimulus;System;Therapeutic;therapeutic target;TNF gene;TNF-related apoptosis-inducing ligand;TNFRSF10A gene;TNFRSF10B gene;Toxic effect;Transactivation;Transcript;transcriptome;Translating;United States;virtual

PROJECT_TITLE: Elucidating the Role of Death Receptor 5 in the Heart

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services

PI_NAMEs: MCWILLIAMS, JOHN MICHAEL (contact)

PROJECT_TERMS: Accountability;accountable care organization;Acute;acute care;Affect;Age;Area;base;beneficiary;bundled payment;care delivery;Caring;Coinsurance;Competitive Bidding;Contracts;cost;County;Data;Data Sources;design;disabled;dual eligible;Elderly;Enrollment;Evaluation;Evolution;experience;Fee-for-Service Plans;financial incentive;flexibility;geographic difference;Goals;Health;Health care facility;health plan;Health Promotion;Heterogeneity;high reward;Hospitals;improved;improved outcome;Incentives;insight;intrinsic motivation;Length of Stay;Link;Managed Care;Measurement;Measures;Medicaid;Medicare;Methodology;Methods;Modeling;Monitor;Natural experiment;Nature;Outcome;Outcome Measure;Patient Care;patient population;Patient-Focused Outcomes;Patients;payment;Performance;Personal Satisfaction;physical therapist;Physicians;Population;Positioning Attribute;Privatization;Process;Production;programs;Prospective Payment System;Provider;provider behavior;Randomized;Research;Residual state;Resources;response;Risk;Risk Adjustment;Risk Assessment;risk selection;risk sharing;Services;Skilled Nursing Facilities;Sorting;Source;System;tool;Variant;wasting

PROJECT_TITLE: Natural Experiments to Understand Plan and Provider Behavior in an Era of Accountability


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The proposed research is relevant to public health because everyone benefits from having effective antibiotics and reducing use of unnecessary antibiotics. In this project, we will test two implementation strategies for an antibiotic stewardship program to decrease overtreatment of asymptomatic bacteriuria, or harmless bladder colonization with bacteria, in hospitals and nursing homes across the United States. This project is relevant to AHRQ’s mission because improving antibiotic use makes health care safer, and it will increase knowledge about how to put evidence into clinical practice.

PI_NAMEs: TRAUTNER, BARBARA WELLS (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: A Cluster Randomized Trial of Two Implementation Strategies to Disseminate a Successful Antibiotic Stewardship Intervention

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: ALBUQUERQUE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The Emergency Department (ED) is a major access point for rural and underrepresented minority (URM) persons seeking mental health (MH) and co-occurring substance use disorder (SUD) treatment, but outcomes after such ED visits are greatly understudied. The overall research goal of this K08 is a detailed, state-based study measuring the effectiveness of New Mexico Medicaid’s Alternative Payment Model (APM) as an intervention in rural and URM communities and scaling these findings nationally through a Technical Expert Panel who will identify key policy and outcome measures for inclusion in Medicaid policy analysis. This work lays the foundation for multistate comparisons to prospectively test the impact of Medicaid policy interventions (e.g., APMs) on rural mental health outcomes.

PI_NAMEs: GREENWOOD-ERICKSEN, MARGARET B (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Improving rural mental health equity through Medicaid policy evaluation - resubmission

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE  THE BIOLOGY OF GENOMES Cold Spring Harbor Laboratory, Cold Spring Harbor, New York  May 9 – 13, 2023  May 7 - 11, 2024  May 6 – 10, 2025  May 5 – 9, 2026  May 11 – 15, 2027 Every species of animal or plant has a distinct set of genes encoded in DNA packaged into discrete chromosomes. The full complement of these genes constitutes the organism's genome. Furthermore the genome of each individual within a species varies slightly, thus providing the genetic basis of the many differences we see between individuals. The technology of DNA sequencing has allowed scientists to construct the shared genome sequence of humans and many species of plant and animal, providing powerful evidence for the evolutionary connections between species. Effort is now going into decoding the genetic differences between individuals within a species, particularly for individual humans and their susceptibility to disease. Many of these advances rely upon interactions between a diverse set of experts, ranging from engineers developing ever faster sequencing technologies, bioinformatics experts who handle the very large datasets generated by these machines, biologists who interpret the results in the context of known biology to shed new light on fundamental mechanisms, and medical experts who seek to apply this information to improved medical treatment and the development of novel therapeutic strategies. This annual conference is one of the major points of exchange for many scientists, editors and associated genome experts to share their latest findings, and provides rapid peer-to-peer communication and networking that is essential to drive the field forward. This Cold Spring Harbor meeting traditionally attracts a very wide and diverse international community.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Animals;Area;Attention;Bioinformatics;Biological Models;Biological Sciences;Biology;career development;Cells;Chromosomes;Collaborations;Communication;Communities;Complex;COVID-19 pandemic;Data;data exchange;Development;Discipline;Disease;DNA Packaging;DNA sequencing;Engineering;Ensure;Environment;Epigenetic Process;ethical, legal, and social implication;experience;Faculty;Fostering;functional genomics;gene complementation;Genes;Genetic;Genome;genome sciences;Genomics;Goals;graduate student;Human;Hybrids;improved;Individual;Industrialization;interest;International;Investigation;Journals;Laboratories;laboratory facility;large datasets;Length of Stay;Malignant Neoplasms;Medical;meeting reports;meetings;microbiome;Nature;New York;Newspapers;next generation;novel therapeutic intervention;Oral;Organism;Participant;peer;Persons;Plants;Population;Postdoctoral Fellow;posters;Predisposition;Publications;Published Comment;Publishing;Recording of previous events;recruit;Reporting;Research;Research Institute;Research Personnel;Schedule;Science;Scientist;Series;single cell genomics;Social Network;success;symposium;Technology;tool;trait;Twitter;unpublished works;virtual;Woman;Work

PROJECT_TITLE: CSHL The Biology of Genomes Conference (2023-2027)

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


PROJECT_TERMS: Acute;Adopted;Affect;Area;beneficiary;care coordination;care delivery;Caring;Categories;Chronic;Clinical;Code;Contracts;copayment;cost;Data;Data Files;Data Set;Data Sources;data submission;Database Management Systems;design;diabetic patient;Diagnosis;Diagnostic;disabled;Drug Prescriptions;Drug usage;Elderly;Enrollment;flexibility;Government;health plan;Healthcare;Heterogeneity;improved;insight;instrument;Insurance Carriers;integrated care;lens;Managed Care;Marketing;Measurement;Measures;Medical;Medicare;Medicare/Medicaid;Methods;Modeling;Outcome;Patient Care;Patients;Pattern;Patterns of Care;payment;Performance;Privatization;programs;Provider;provider networks;Regulation;Research;Resources;Risk;Risk Adjustment;risk selection;risk sharing;Role;Savings;service utilization;Source;Structure;success;System;tool;Translating;Work

PROJECT_TITLE: Looking Under the Hood of MA


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: MCGUIRE, THOMAS G. (contact)

PROJECT_TERMS: accountable care organization;Address;Adult;Affect;Age;Aging;American;beneficiary;California;care delivery;care outcomes;Caring;Characteristics;Chronic;community based service;Contracts;Control Groups;Data;Dental;design;differences in access;disability;disabled;Drug Prescriptions;Drug usage;dual eligible;Dual Enrollment;Elderly;Enrollment;evidence base;Federal Government;Fee Schedules;Fees;flexibility;geographic difference;Health;health care availability;health care delivery;health care quality;Health Insurance;Health Promotion;Healthcare Systems;Home;Hospitalization;improved;Individual;insight;Institution;Insurance;Insurance Benefits;Insurance Coverage;Laboratories;Learning;Link;Low income;Managed Care;Managed Care Programs;Medicaid;Medicaid eligibility;Medicare;Medicare/Medicaid;Methods;Montana;mortality;Nature;New Jersey;North Dakota;novel;Outcome;Pathway interactions;Patient Care;Patient-Focused Outcomes;Pattern;payment;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;prior authorization;Privatization;programs;Provider;Quasi-experiment;Research Design;Resources;Rhode Island;Role;Services;social;Social Security;Source;Structure;System;Time;treatment group;trend;United States;United States Social Security Administration;Variant;Vision;Work;Wyoming

PROJECT_TITLE: Learning from Program Differences between Medicaid and Medicare