NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This application is for the continued participation of the Saint Louis University Clinical Center in the NASH Clinical Research Network (NASH CRN) during its final 3 years. By completing a vitamin E dosing trial initiated in the prior funding cycle, conducting the final visits for the observational trial patients, and analyzing newly available genomic and transcriptomic data, this project will continue to build on the understanding of the pathogenesis, diagnosis, treatment and natural history of metabolic dysfunction associated liver disease that has been the major contribution of the NASH CRN during its prior 20 years.

PI_NAMEs: NEUSCHWANDER-TETRI, BRENT A (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Adult;Affect;Animal Model;biomarker discovery;biomarker validation;Cardiovascular system;Case Study;Cell Culture Techniques;Cellular Stress;Cessation of life;Child;Childhood;Cirrhosis;clinical center;Clinical Management;Clinical Research;Clinical Trials;cohort;college;cost;Data;Data Analyses;data repository;Data Set;Databases;Development;Diagnosis;disease natural history;Disease Progression;Dose;Enrollment;Event;Experimental Models;Fibrosis;follow-up;Functional disorder;Funding;Future;genetic variant;Genomics;Genotype;Health;Histologic;Human;Human Genetics;Impairment;improved;Knockout Mice;Knowledge;Laboratories;Link;Lipase;Lipids;Lipolysis;Liver;Liver diseases;liver transplantation;Longitudinal cohort;Manuscripts;Medicine;meetings;Metabolic;Metabolic dysfunction;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Observational Study;Outcome;Paper;participant enrollment;Pathogenesis;Patients;Pattern;Performance;Persons;Phase;Phenotype;Positioning Attribute;prevent;Prevention;Primary Malignant Neoplasm of Liver;Principal Investigator;Productivity;programs;prospective;protein expression;Proteins;Public Health;Publications;Research;Research Personnel;Resources;Risk;Risk Factors;Rodent;Role;Sampling;Site;Steatohepatitis;success;Testing;Therapeutic Agents;Tissue-Specific Gene Expression;transcriptomics;Translational Research;Triglycerides;United States National Institutes of Health;Universities;Variant;virtual;Visit;Vitamin E;Work;Writing

PROJECT_TITLE: The Saint Louis University Component of the NASH Clinical Research Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Patient Safety;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE This proposal will embark on studies of large-scale electronic health records (EHRs) of diverse ancestries with comprehensive phenome assessed during the course of diabetes and conduct multi-omics integration to subtype diabetes using clinical features, to identify subtypes in response to treatments for diabetes and cardiometabolic disease, and to perform in-depth multi-omics diabetes subtyping in African Americans.

PI_NAMEs: GAMAZON, ERIC R;NG, MAGGIE  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Affect;African American population;Age of Onset;Algorithms;autoimmune pathogenesis;Beta Cell;Biological Markers;Biological Process;Blood;Blood Pressure;Body mass index;Brain;C-Peptide;Cardiometabolic Disease;Cell Count;Classification;Clinical;clinical application;clinical practice;clinical risk;comorbidity;Complex;Complications of Diabetes Mellitus;Data;Defect;Development;diabetes management;Diabetes Mellitus;diabetes risk;diabetic patient;Diagnosis;Disease Progression;disorder subtype;effective intervention;Electronic Health Record;endocrine pancreas development;Energy Metabolism;Epigenetic Process;Ethnic Population;Family;Fatty acid glycerol esters;Functional disorder;genetic predictors;Glucose;glycemic control;improved;in silico;Individual;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Islet Cell;islet cell antibody;Laboratories;large datasets;Lipids;Liver;maturity onset diabetes of the young;Medical;metabolome;Methylation;methylome;Modeling;Multiomic Data;multiple omics;Muscle;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organ;Pancreas;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;phenome;Phenotype;Physiological;Physiological Processes;predictive modeling;Process;Production;Prognosis;Proteome;racial population;Recording of previous events;Resources;response;Risk;Risk Factors;Sampling;senescence;social health determinants;Syndrome;Time;transcriptome;treatment response;Variant;whole genome

PROJECT_TITLE: Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (M1)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE The federal agencies and professional organizations have mounted a significant effort to address an increasingly recognized public health problem, Early Childhood Caries (ECC), among the underserved population. A better understanding of the biological factors related to this pediatric oral health disparity is urgently needed.  Leveraging an archived underserved birth cohort, our multidisciplinary team proposes using cutting- edge metagenomic sequencing and analysis tool, combined with a high-dimensional statistical machine learning approach, to examine the early-life oral microbiome development and identify its multilevel determinant and association to ECC. ECC risk factors revealed via prediction models could be used as targets for ECC early prediction and prevention specifically suitable for underserved racial minority children.

PI_NAMEs: GILL, STEVEN R.;WU, TONGTONG ;XIAO, JIN  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Advisory Committees;Affect;African American;Archives;Bacteria;Behavior;Biological;Biological Factors;Biometry;Birth;Black race;career;Caries prevention;cariogenic bacteria;Child;Child Development;Childhood;cohort;Collection;Communicable Diseases;Communities;Computer Models;Counseling;craniofacial;Data;data platform;Data Sources;Dental;Dental caries;Development;Dietary Iron;Dietetics;Discipline;Disparity;dysbiosis;early childhood;early onset;early-life nutrition;Eating Behavior;Ensure;Environment;Environmental Risk Factor;ethnic minority;Exposure to;Foundations;fungus;Future;Genes;Genetic;Goals;gut microbiome;Health;Health Disparities Research;health disparity;health record;high dimensionality;Household;Human;Immune;Immunologic Factors;Immunologic Markers;in utero;infancy;Infant;Infant Development;innovation;Intake;Life;Life Cycle Stages;Low income;Machine Learning;machine learning prediction;Medical;metagenomic sequencing;Metagenomics;Methods;microbial;microbial composition;microbiome;microbiome composition;microbiome research;microbiota;Minority;minority children;minority communities;Modeling;Mothers;multidisciplinary;Mycoses;National Institute of Dental and Craniofacial Research;nutrition;Nutritionist;Oral;oral bacteria;Oral candidiasis;Oral health;oral microbial community;oral microbiome;oral supplementation;parent project;Parents;Pattern;Perinatal;Pica Disease;predictive modeling;Pregnancy;Pregnant Women;prenatal;Preschool Child;Prevention;Professional Organizations;Public Health;Race;racial disparity;racial minority;racial minority population;racial population;Research;Research Personnel;Risk;Risk Factors;Saliva;Salivary;Sampling;Severities;Shapes;skills;socioeconomic disparity;Socioeconomic Status;Solid;statistical and machine learning;Streptococcus mutans;success;Testing;Time;tool;Training;transmission process;Underserved Population;Woman;Work;yeast infection;Yeasts

PROJECT_TITLE: Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HONOLULU

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative This program is aimed to develop, implement and share undergraduate- and Master’s-level curricula and methods in computational genomics and data science (CGDS) education and research, and interact with the community scientists and members of CGDS Educational Hub. The project will create CGDS curricula with a focus on the utility of NIH cloud resources for biomedical research and education. This program will serve the diverse and underrepresented students and scientific community members to improve knowledge and applications of CGDS.

PI_NAMEs: DENG, YOUPING  (contact);ZHANG, YIQIANG

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Address;Adoption;Area;Articulation;Behavioral;Behavioral Sciences;Big Data;Biomedical Research;biomedical resource;Cardiovascular Diseases;career;catalyst;Cause of Death;cloud based;Cloud Computing;Collaborations;Communities;Community Health Education;Complex;computational platform;Computer software;computerized tools;computing resources;Creativeness;cyber infrastructure;Data;Data Analyses;Data Commons;Data Science;data science education;Data Set;data sharing;Diabetes Mellitus;Disease;Distant;DNA Methylation;Education;education research;education resources;Educational Activities;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational Status;Enrollment;epigenomics;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;Exercise;experience;Exposure to;Faculty;Fostering;Funding Opportunities;Future;Genetic;Genome;genome sciences;genomic data;Genomics;Goals;Hawaii;Health;health data;health disparity;Human;improved;innovation;Institution;interoperability;Knowledge;Licensing;Malignant Neoplasms;Master of Science;Medical;member;Mentors;Methods;minority health;Minority-Serving Institution;Mission;multi-racial;Mutation Analysis;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;Native Hawaiian or Other Pacific Islander;Performance;Personal Satisfaction;Persons;Population;Population Heterogeneity;programs;Provider;public trust;racial minority;racial population;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;RNA methylation;Science;Scientist;single cell sequencing;Site;skills;Speed;statistics;Strategic vision;Students;System;Technology;Testing;Training;Training and Education;training opportunity;transcriptomics;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: Pacific Computational Genomics and Data Sciences Research Education Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M1)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Kidney Disease;Regenerative Medicine

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Repeated episodes of kidney injury often result in progressive and irreversible scarring and loss of function. This application seeks to investigate mechanisms for kidney tissue regeneration by understanding how gene expression is regulated by epigenetic changes in the African spiny mouse, an animal model that can regenerate kidney tissue after injury.

PI_NAMEs: NGUYEN, ELIZABETH DONG (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acomys;African;Animal Model;Atlases;Automobile Driving;Binding;career;career development;Cell Cycle Regulation Pathway;Cell Proliferation;cell regeneration;Cells;Child;Childhood;Chromatin;Chronic Kidney Failure;Cicatrix;Clinical;Committee Members;Computational Biology;Data;Data Analyses;Development Plans;Dialysis procedure;Doctor of Philosophy;Epigenetic Process;epigenetic regulation;epigenomics;Epithelial Cells;Evolution;Exhibits;experience;Experimental Models;Family;family burden;Fibrosis;Foundations;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;Genomics;Goals;Growth;healing;Healthcare Industry;histone modification;Histones;Histopathology;Hour;House mice;Human;Impairment;Individual;Inflammation;Inflammatory;Injections;Injury;injury and repair;Injury to Kidney;interest;Investigation;ischemic injury;K-Series Research Career Programs;Kidney;Kidney Diseases;kidney repair;loss of function;Maps;Mediating;Mentors;Mentorship;Methods;Mission;Modeling;Monitor;mouse genome;multiple omics;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;nephrogenesis;Outcome;Pathway interactions;patient navigation;Patients;Pharmaceutical Preparations;Play;prevent;Process;Proliferating;Proteins;Reaction;Recording of previous events;reference genome;regeneration model;regenerative;regenerative biology;Regenerative capacity;Regenerative response;Regulatory Element;Renal function;repaired;Reperfusion Injury;Research;Research Institute;Research Personnel;Resources;response;response to injury;Role;single-cell RNA sequencing;skills;stem cell biology;Strategic Planning;symposium;Teacher Professional Development;Technology;Testing;tissue regeneration;Tissues;Training;transcription factor;Transcriptional Activation;Transcriptional Regulation;Transplantation;Tubular formation;United States;Ureteral obstruction;Verteporfin

PROJECT_TITLE: Epigenetic regulation of kidney regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH SIGNIFICANCE The proposed research, training and mentoring are relevant to public health as they address the need for scholars of differing perspectives and disciplinary backgrounds to address multilayered problems that arise in the care of people with Alzheimer’s disease and related dementias. The new research outlined in this proposal pertains to several recognized problems in dementia caregiving, such as caregiver burden, ethical concerns about how surrogate decisions reflect patients’ own values, and insufficient enrollment in clinical trials. The training and mentoring program will facilitate the training of new leaders in patient-oriented research across neurology, neuroscience, geriatrics, palliative care and bioethics.

PI_NAMEs: CHIONG, WINSTON  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Accountability;Acute;Address;Adult;Affect;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Applications Grants;Award;Behavioral;behavioral economics;beneficiary;Bioethics;Brain;Brain Diseases;California;care recipients;career;career development;Caregiver Burden;Caregiver research;Caregivers;caregiving;Caring;Chronic;Client;Clinical;clinical care;clinical trial enrollment;Clinical Trials;Cognition;cognitive function;cognitive neuroscience;Cognitive Science;cohort;Collaborations;Complex;Conflict (Psychology);Decision Making;Dementia;dementia care;Dementia caregivers;dementia caregiving;Development;Discipline of Nursing;Doctor of Philosophy;Elder Abuse;Enrollment;Ethics;Family;Fellowship;Funding;Geriatrics;Goals;Health;health disparity;health equity;Home;Incentives;innovation;Institution;Interdisciplinary Study;interest;Intuition;Knowledge;Learning;Legal;Longevity;marginalized population;Measures;Medical;Medicine;Mentors;Nervous System Disorder;Neurobiology;neuroethics;Neurologic;Neurologist;Neurology;Neurosciences;novel;Outcome;Palliative Care;patient oriented research;Patients;Persons;Philosophy;Policies;Politics;preservation;programs;Psychologist;Psychology;psychosocial;Public Health;Pupil;Research;Research Support;Risk;sample fixation;San Francisco;Secure;Social Environment;social stigma;Sociology;surrogate decision making;teacher;Time;Training;Universities;web platform;Work

PROJECT_TITLE: Dementia caregiving and the cognitive science of surrogate decisions

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioids;Pain Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_NAME: NAVEGA THERAPEUTICS, INC.

PHR: Project Narrative Currently 1.5 billion people worldwide suffer from chronic pain. In the parent grant, we propose to optimize epigenetic modulators to achieve analgesia with high specificity and efficacy without addictive properties in a long-lasting manner. This supplement will contribute to the optimization of the delivery of the therapy to improve tissue-specificity and decrease manufacturing costs, which will translate to a more affordable therapy for patients.

PI_NAMEs: ALEMAN GUILLEN, FERNANDO  (contact);MORENO, ANA MARIA

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: Absence of pain sensation;Analgesics;Burning Pain;cancer survival;chronic pain;chronic pain management;Dangerousness;design;Diabetes Mellitus;Disease;DNA;Drug Kinetics;Economic Burden;efficacious treatment;Elderly;Epigenetic Process;Erythromelalgia;gain of function mutation;gene therapy;Genome;Grant;improved;interest;Limb structure;loss of function;manufacturing cost;Marketing;Methods;Opioid;opioid epidemic;Pain;pain reduction;parent grant;Parents;patient population;Patients;Persons;Population;pre-clinical;Prevalence;Property;Proteins;Quality of life;Repression;RNA;Societies;socioeconomics;Sodium Channel;Specificity;Survival Rate;Tissues;Translating

PROJECT_TITLE: Preclinical optimization of a gene therapy for erythromelalgia and chronic pain


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: West Sacramento

ORG_NAME: TENVOS INC.

PHR: Project Narrative This project will aid in developing a non-invasive, remote, and easily deployable tool to screen patients for opioid use, facilitating clinicians in diagnosing and treating opioid use disorder. The deployment of this tool will improve patient care by making diagnosis and treatment more accessible, accelerating the process, reducing costs, and reducing patients’ discomfort via non-invasive screening. Through identifying acoustic biomarkers associated with opioid use, this research will contribute to the scientific community’s understanding of opioids’ effects on voice production.

PI_NAMEs: SEIILOVA-OLSON, RIMA  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acoustics;Address;Administrator;Affect;Ambulatory Care;Appointment;Artificial Intelligence;barrier to care;Biological Markers;Buprenorphine;Caring;Categories;Characteristics;Clinical;Clinical Data;commercialization;Communities;Complex;cost;Counseling;Data;Data Collection;Detection;Diagnosis;drug testing;Grant;Health;High Prevalence;Home;Hospitalization;Imprisonment;improved;improved outcome;Individual;inpatient service;Inpatients;Intervention;Investments;Laboratories;Low Income Population;machine learning model;Measures;Medical center;medication for opioid use disorder;Methadone;Methodology;National Institute of Drug Abuse;Nature;novel strategies;Observational Study;Opioid;opioid use;opioid use disorder;Outpatients;outreach;Overdose;Patient Care;patient screening;Patient Selection;Patients;Persons;Phase;Physiological;Population;Privacy;Process;Production;programs;Provider;Quality of Care;Research;Resources;retention rate;Risk;Rural;sample collection;Sampling;screening;Sensitivity and Specificity;Site;smartphone application;social stigma;Speech;Substance Use Disorder;Technology;Telemedicine;Telephone;Testing;Time;tool;Training;Transportation;treatment center;United States National Institutes of Health;Universities;virtual;virtual health;virtual patient;Visit;Voice;Work

PROJECT_TITLE: Remote and Non-Invasive Opioid Use Screening to Lower Barriers to Substance Use Disorder Diagnosis and Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-S (M1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE As fathers are increasingly more involved in child rearing and play a critical role in child development, it is important to understand the relationship between paternal preconception factors and the wellbeing of the next generation. The proposed study will examine the relationships between fathers’ adverse childhood experiences (ACEs), fathers’ behavioral health, fathering practices, and in turn offspring wellbeing. By also exploring the within parent dyad experience of ACEs on offspring wellbeing, findings from the proposed study can be used to inform trauma-informed family interventions.

PI_NAMEs: GRAFFT, NATALIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescent;Adult;adverse childhood events;adverse outcome;Affect;Age;Behavior;behavioral health;Boston;Buffers;Child;Child Development;Child Health;Child Mental Health;Child Rearing;Childhood;Cohort Studies;college;Communities;community violence;Conceptions;Data;data management;design;Development;Discrimination;Environment;ethnic minority;Ethnic Origin;experience;Exposure to;externalizing behavior;Face;Family;Fathers;Functional disorder;Future Generations;Generations;Growth;Health;Health behavior;Health behavior and outcomes;health equity;Health Status;Home;Household;Individual;intergenerational;Intervention;Knowledge;Life Cycle Stages;Link;Literature;longitudinal dataset;longitudinal design;Longitudinal Studies;Low Birth Weight Infant;Low income;Maternal and Child Health;Maternal Exposure;Measurement;Measures;Mediating;Mental Health;Mentorship;Methodology;Methods;Modeling;Mothers;National Longitudinal Survey of Adolescent to Adult Health;neglect;next generation;novel;offspring;Outcome;Parents;Pathway interactions;Personal Satisfaction;physical conditioning;Play;Public Health;public health priorities;Publishing;Race;racial minority;Reporting;Research;Research Personnel;Research Proposals;Research Training;Risk Behaviors;Role;Sampling;Shapes;skills;Training;transmission process;Trauma;traumatic event

PROJECT_TITLE: Fathers' adverse childhood experiences (ACEs) and offspring health and wellbeing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Evaporative dry eye disease is a common ophthalmic condition that is caused by decreased stability of the tear film, usually due to abnormalities in the tear film lipid composition and/or secretion. This proposal will investigate the mechanisms that govern tear film stability and modulate them with a novel, targeted therapeutic nonpolar lipid found in the tear film of the rabbit. Additionally, this proposal will investigate the effect of this targeted therapeutic on tear film lipid composition and secretion and the effect of the rabbit lipid on ocular surface health in an animal model of evaporative dry eye disease.

PI_NAMEs: HISEY, ERIN ALISSA (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acinar Cell;Acyl Coenzyme A;Acyltransferase;Affect;Air;Alcohols;Animal Model;aqueous;Atrophic;Autopsy;Binding;Biological Models;Blinking;Cell Aging;Characteristics;Cholesterol Esters;Clinical;clinical application;clinical efficacy;Complex;Confocal Microscopy;Cornea;corneal epithelium;Data;design;Disease;Dry Eye Syndromes;Duct (organ) structure;Environment;Equation;Esters;evaporation;eye dryness;Film;fluidity;Fluorescence Recovery After Photobleaching;Formulation;Future;Gene Expression;Gland;Health;High Prevalence;Histopathology;Human;improved;In Vitro;in vitro Model;in vivo;Investigation;irritation;Kinetics;knockout animal;Knockout Mice;Label;Lead;lipidomics;Lipids;Liquid substance;Maps;meibomian gland;meibomian gland dysfunction;Methods;Modeling;mouse model;mRNA Expression;Mus;novel;novel therapeutics;Obstruction;ocular surface;ocular surface disease;Oryctolagus cuniculus;palliative;Patients;Persons;Phase;Phenotype;Prevalence;Rest;Role;segregation;senescence;targeted treatment;Temperature;Therapeutic;therapeutically effective;Time;time use;Tissues;transcriptomics;Transillumination;treatment group;United States;Visual impairment;Waxes;Work

PROJECT_TITLE: Redefining the factors that determine tear film stability to develop novel therapeutics for evaporative dry eye disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Yersinia pestis, the etiologic agent of the plague, has refined mechanisms to manipulate the host immune response and suppress inflammation. This project will define the impact of disrupting extracellular vesicle trafficking and illustrate how this manipulation contributes to disease pathogenesis. Understanding these mechanisms of immune subversion is essential for the development of novel targeted therapeutics.

PI_NAMEs: SHENEMAN, KATELYN RENEE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: acute infection;Antibacterial Response;antimicrobial;Bacteria;Bacterial Infections;Binding;Biochemical;cell type;Cells;Communication;cytokine;Data;Dependence;Development;Disease;Disease Progression;Endocytosis Inhibition;Environment;Etiology;Exocytosis;extracellular vesicles;Generations;Goals;Hour;Human;human disease;Immune;Immune response;Immune system;immunoregulation;improved;In Vitro;in vivo;in vivo evaluation;Infection;Inflammation;Inflammatory;Inflammatory Response;intercellular communication;Intervention;Invaded;Knowledge;Lipids;Lung;Lung infections;Maintenance;Mediating;Mediator;Membrane;mutant;neutrophil;Neutrophil Infiltration;new therapeutic target;Nucleic Acids;Organism;Outcome;pathogen;Pathogenesis;Pathway interactions;Phagocytes;Phagocytosis;Phase;Plague;Play;Pneumonic Plague;Population;Production;Productivity;Proliferating;Protein Secretion;Proteins;Pulmonary Inflammation;response;Role;Signal Pathway;Testing;Time;Tissues;tool;trafficking;Type III Secretion System Pathway;Vesicle;Virulence;Work;Yersinia pestis

PROJECT_TITLE: Defining the impact of Extracellular Vesicles on inflammation during pneumonic plague


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Constriction of arterial blood vessels due to atherosclerosis is a leading cause of death worldwide, but current treatment is limited because administering clot-lysing drug entails a high risk of bleeding when distributed throughout the body. Using the fact that stenotic vessels exhibit abnormally high shear stress, we propose to develop shear stress-responsive synthetic cells as a targeted drug delivery system that can selectively release drugs in constricted blood vessels. This work will allow a deeper understanding of a mechanosensitive protein employed in this system to enable its broader use in the future and will contribute to expanding the application boundary of the synthetic cell in the biomedicine field.

PI_NAMEs: HWANG, SUNG-WON  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Aging;Anticoagulants;Atherosclerosis;Attention;Behavior;Biological Process;Biosensor;Blood flow;Blood Platelets;Blood Vessels;Calcium;Cause of Death;Cell Size;Cells;Chemicals;Coagulation Process;constriction;controlled release;Cues;Development;Diameter;Disease;Drug Carriers;Drug Delivery Systems;Drug Targeting;Effectiveness;Embolism;Emulsions;Encapsulated;Engineering;Environment;Excision;Exhibits;experimental study;Fibrin;Fibrinolytic Agents;Fluorescein-5-isothiocyanate;Fluorescence;Fluorescent Dyes;Future;Goals;Heart Valve Diseases;hemodynamics;Hemorrhage;high risk;Human body;In Vitro;Inflammation;innovation;Life;Lipid Bilayers;Lipids;Liquid substance;Long term disability;mechanical force;mechanical signal;mechanical stimulus;Membrane;Membrane Proteins;Methods;Microfluidics;Modeling;Monitor;mutant;Myocardial Infarction;Normal Range;novel;Obstruction;Oils;optical imaging;Osmosis;Outcome;Pharmaceutical Preparations;Physiological;Platelet aggregation;Proteins;reconstitution;Reporter;response;Risk;Shapes;shear stress;Signal Transduction;Site;Stenosis;Stimulus;Stress;Stretching;Stroke;stroke therapy;System;Techniques;Testing;Theoretical Studies;Thrombosis;vascular injury;Vesicle;Water;Width;Work

PROJECT_TITLE: Shear stress-activated synthetic cells for targeted drug release in stenotic blood vessels


NIH_SPENDING_CATS: Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Organismal survival relies on the ability of germ cells to pass their genetic information from one generation to the next. This proposal seeks to understand how small RNA pathways regulate germline gene expression to ensure proper transgenerational transmission of genetic information.

PI_NAMEs: GIRGENRATH, JOHAN  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Animals;Binding;Biochemistry;Bioinformatics;Biological Assay;Biological Process;Caenorhabditis elegans;career;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Collaborations;Complex;Data;Deacetylase;Defect;Development;Developmental Biology;Embryo;embryo tissue;Ensure;Fertility;Future;Gene Expression;Gene Silencing;Generations;Genetic;genetic information;Genome Stability;Germ Cells;Germ Lines;Goals;Gonadal structure;Heterochromatin;Histone Deacetylase;Human;Hybrids;Immunofluorescence Immunologic;induced pluripotent stem cell;insight;Knock-out;Laboratory Finding;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;Microscopy;mRNA sequencing;Mus;mutant;Mutate;Nuclear;Nucleosomes;Pathway interactions;piRNA;Plants;prevent;Proteins;Publishing;recruit;Regulation;Research Personnel;Role;self-renewal;Site;Small RNA;Sumoylation Pathway;Testing;Tissues;Training;Transcript;transmission process;Ubiquitin;Work

PROJECT_TITLE: Investigating the role of Sumo in piRNA-mediated germline heterochromatin maintenance in C.elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The outreach goal of the proposed research project is to develop a new combination of targeted drug delivery and immunotherapy for the treatment of advanced pancreatic cancer. Our innovative designs of tumor penetrating and immune modulating theranostic nanoparticles, coupled with a novel nanoparticle PD-L1 inhibitor (Nano-iPD-L1), enable efficient delivery of chemotherapy drugs and immunotherapy agents into stroma-rich pancreatic cancer tissues to destroy drug resistant tumor cells, modulate an immunosuppressive microenvironment into a pro-immune environment, and generate strong immune responses. Results of this translational research project have the potential for the development of a targeted and image-guided cancer therapy that significantly enhances therapeutic efficacy, and activates tumor specific immune response, and improves survival of pancreatic cancer patients.

PI_NAMEs: MAO, HUI ;YANG, LILY  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: advanced pancreatic cancer;Affinity;Basement membrane;Biodistribution;Biological;Biology;cancer classification;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;Catalytic Domain;CD8B1 gene;cell killing;cell type;Cells;checkpoint therapy;chemotherapy;Clinical;Combined Modality Therapy;Coupled;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Development;Disease;Distant;Dose;Doxorubicin;draining lymph node;Drug Carriers;Drug Delivery Systems;drug distribution;Drug Kinetics;Drug Monitoring;Drug resistance;Drug Targeting;Duct (organ) structure;Effector Cell;effector T cell;Engineering;Environment;Extracellular Matrix;Fibroblasts;Goals;Human;image guided;image guided therapy;image-guided drug delivery;imaging agent;Immune;immune cell infiltrate;immune checkpoint;Immune response;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;innovation;irinotecan;iron oxide nanoparticle;ITGAX gene;KRAS oncogenesis;Lead;Ligands;Macrophage;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of pancreas;Malignant Neoplasms;migration;MMP14 gene;Modeling;Monitor;mouse model;Mus;Myeloid-derived suppressor cells;nanoparticle;nanoparticle delivery;nanoparticle drug;neoplastic cell;novel;novel therapeutics;outreach;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;patient derived xenograft model;PDL1 inhibitors;Penetration;Peptides;peptidomimetics;Pharmaceutical Preparations;Phenotype;PLAUR gene;Population;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Recombinants;Regulatory T-Lymphocyte;Research;Research Project Grants;Resectable;response;sialic acid binding Ig-like lectin;Signal Transduction;Spleen;Stromal Cells;success;targeted cancer therapy;targeted delivery;targeted treatment;theranostics;Therapeutic Effect;therapy resistant;Tissues;Transgenic Mice;Translational Research;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Promotion;tumor-immune system interactions;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Never in mitosis A-related kinase (NEK) family of protein kinases is an important, yet understudied, kinase family that has recently been implicated in a variety of disorders, including numerous cancers, ciliopathies, chronic inflammatory diseases, and neuronal disorders. The lack of reliable tools to study NEK function has made it difficult to determine the specific role(s) that NEK family members play in the etiology and progression of these diseases. In the proposed project, we will use a generalizable, family-based strategy to develop a suite of tools, including high quality chemical probes, that will be made freely available to the biomedical researcher community and enable researchers to build a firm understanding of how these understudied kinases contribute to health and disease and validate new druggable targets for cancer drug discovery.

PI_NAMEs: BUROW, MATTHEW E.;DREWRY, DAVID HAROLD (contact);NEWMAN, ROBERT HOWARD

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Active Sites;Address;Antineoplastic Agents;Binding;Biological;Biological Assay;Biological Process;Biology;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell Line;cell motility;Cells;Cellular biology;Chemicals;chronic inflammatory disease;ciliopathy;cilium biogenesis;Communities;Data;design;Development;Diabetes Mellitus;Disadvantaged;Disease;Disease Progression;DNA biosynthesis;DNA Damage;drug development;drug discovery;drug quality;Drug Targeting;druggable target;Environment;Etiology;Family;Family member;FDA approved;Foundations;Free Will;Funding;Generations;Genome;Health;holistic approach;Human;Individual;Inflammation;Inflammatory Bowel Diseases;inhibitor;insight;kinase inhibitor;knock-down;Knock-out;Knowledge;lead optimization;Left;Link;Malignant Neoplasms;Measures;Medicine;member;migration;Mission;Mitosis;Modality;Molecular;Nature;Neurons;new therapeutic target;Oncology;Output;Pathologic;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Physiological;Play;Process;programs;Proliferating;Protein Family;Protein Kinase;Proteins;Proteome;Reagent;Reporter;Research;Research Personnel;Resources;response;RNA Splicing;Role;scaffold;Scientist;Signal Pathway;Signal Transduction;small molecule;success;System;Therapeutic;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Identification and characterization of chemical probes for interrogation of the NEK family of kinases in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stomach Cancer

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research to study germline CDH1 variants and obesity in Hispanic/Latino gastric cancer patients is relevant to public health because it may lead to the first discovery of a molecular cause for gastric cancer health disparities experienced by these patients. The expected results could guide genetic testing criteria and lifestyle recommendations that enable the prevention or early detection of gastric cancer. Thus, the proposal is relevant to the NIH's mission to reduce illness and lengthen life.

PI_NAMEs: WANG, SAM C. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Accounting;Age;Automobile Driving;Behavior;Benign;Biological Assay;Biology;cancer health disparity;Cancer Patient;CDH1 gene;Cell Adhesion Molecules;Cell Line;Characteristics;clinical epidemiology;clinically actionable;cohort;Data;Development;Diagnosis;Diet;Diffuse gastric cancer;Disease;disease-causing mutation;Disparity;E-Cadherin;Early Diagnosis;early onset;Engraftment;Enrollment;Environmental Exposure;Epidemiology;Epidermal Growth Factor Receptor;exome sequencing;experience;Face;gastric organoids;gene environment interaction;Genetic;genetic testing;Genomics;Germ Lines;Growth;Guidelines;health difference;Helicobacter Infections;Heterogeneity;High Prevalence;high risk;Hispanic;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;Inflammatory Response;Inherited;innovation;Latino;Latino Population;Life;Life Style;lifestyle factors;lifetime risk;Logistic Regressions;Loss of Heterozygosity;Malignant Neoplasms;malignant stomach neoplasm;Masks;Methods;Mission;Modeling;Modification;Molecular;multidisciplinary;Not Hispanic or Latino;novel;Obese Mice;obese patients;Obesity;Onset of illness;Organoids;Outcome;outcome disparities;participant enrollment;Pathogenicity;Pathway interactions;Patients;Penetrance;Phenotype;Population Heterogeneity;Prevalence;Prevention;protein expression;Public Health;Publishing;Recommendation;Registries;Research;Research Personnel;Risk;Role;Sampling;Screening for Gastric Cancer;Signal Transduction;Syndrome;System;Testing;Thinness;tool;Transgenic Mice;tumor;tumor growth;tumor-immune system interactions;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Determining the role of germline CDH1 variants in gastric cancer outcome disparities in Hispanic/Latino patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Palliative Care;Rehabilitation

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE This Award supports the career development of Garrett T. Wasp, MD, MPH, a medical oncologist at Dartmouth Cancer Center whose long-term career goal is to become a leading investigator in health services and communication research focused on promoting high-quality and goal-concordant cancer care. The training and mentoring plan is designed to provide knowledge and skills in designing and leading clinical trials, behavioral intervention development and testing, implementation science, and professional development. The research component follows a user-centered design process and Behavior Change Wheel intervention development framework to systematically develop and evaluate an interactive visual aid (VIS) for use by patients with advanced cancer, their caregivers, and clinicians to approach decisions to stop cancer treatment.

PI_NAMEs: WASP, GARRETT T (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adult;Advance Care Planning;Advanced Malignant Neoplasm;Affect;Anxiety;arm;Attention;Award;Behavior;behavior change;behavior change wheel;Behavior Therapy;cancer care;Cancer Center;cancer imaging;cancer therapy;care outcomes;care preference;career;career development;Caregivers;Caring;chemotherapy;Clinical;Clinical Trials;Communication;communication behavior;Communication Methods;Communication Research;Communication Tools;Complex;Comprehensive Cancer Center;Consultations;Decision Aid;Decision Making;design;Development;Documentation;Emotional;Emotions;end of life care;Frequencies;Goals;health service use;Health Services Research;implementation science;improved;innovation;insight;K-Series Research Career Programs;Knowledge;low health literacy;Malignant Neoplasms;Measures;Medical;Medical Oncologist;Medical Oncology;medical specialties;Mental Depression;Mentors;Methods;Modeling;Needs Assessment;novel;Observational Study;Oncology;open label;Outcome;Outpatients;Palliative Care;Participant;patient oriented;Patient-Focused Outcomes;Patients;Phase Transition;Practice Guidelines;preference;Process;process improvement;Prognosis;psychologic;Radiation therapy;Research;Research Methodology;Research Personnel;Sampling;Scientist;skills;Structure;support tools;Testing;therapy development;Time;tool;Training;treatment as usual;Uncertainty;United States;usability;user centered design;Visit;Visual;Visual Aid;Wasps;Work

PROJECT_TITLE: Developing and Testing an Interactive Visual Aid for Approaching Decision Making to Stop Cancer Treatment in Advanced Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Suicide

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: Project Narrative/Relevance Statement This proposal aims to identify profiles of suicide ideation and expressions of distress in children, 8-12 years old, using mixed methods and a multi-informant approach. Findings will provide information that can be used to inform developmentally and culturally meaningful assessments of suicide risk with children and their caregivers.

PI_NAMEs: GULBAS, LAUREN E.;MIRANDA, REGINA  (contact);ORTIN-PERALTA, ANA

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 12 year old;Accident and Emergency department;Address;Adolescent;Age;Age of Onset;Attention;bilingualism;Black race;bodily sensation;body map;boys;Brain;Caregivers;Characteristics;Child;Child Psychiatry;Childhood;children of color;Chronic;Clinical;clinically relevant;Cognition;cognitive development;community advisory board;community engagement;Complement;Consultations;Data;design;Development;Distress;early adolescence;Emotions;ethnographic method;ethnoracial;ethnoracial minority;Event;experience;Feeling;Feeling suicidal;Frequencies;Future;girls;Goals;Health;high risk;improved;informant;Interview;Latina;Latinx;Measurement;Measures;Methods;Mission;National Institute of Mental Health;New York;New York City;non-verbal;Not Hispanic or Latino;Pathway interactions;phenomenological models;Psychopathology;recruit;Reporting;Research;response;Risk;Risk Assessment;Risk Marker;Sampling;Severities;Spanish/English;suicidal adolescent;suicidal risk;Suicide;Suicide attempt;suicide rate;Testing;Texas;Thinking;Time;United States;verbal;Visit;Visual;Youth

PROJECT_TITLE: A mixed-methods, multi-informant study of childhood suicide ideation to improve risk assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (05)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hepatitis;Infectious Diseases;Liver Disease;Nanotechnology

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project narrative: Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and a significant risk factor for solid organ transplant patients who become chronically infected by HEV. Generating new therapeutics to combat chronic HEV infection requires delivery of virucidal molecules to primary sites of HEV replication. This project will assess efficacy of HEV genome targeting CRISPR therapies and apply a new technology to enhance delivery of HEV genome targeting CRISPR therapies to liver cells, thereby providing new insights on candidate therapies.

PI_NAMEs: GOURAPURA, RENUKARADHYA JAYAMURTHY;KENNEY, SCOTT P (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: A549;Acute;Aftercare;Alveolar;Animal Model;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;Capsid;Capsid Proteins;Cell Culture System;Cell Culture Techniques;Cell Line;cell type;Cells;Cessation of life;Chronic;Chronic Hepatitis;chronic infection;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combat;Death Rate;Developing Countries;Development;Disease;efficacy evaluation;Emerging Technologies;Epithelial Cells;Escape Mutant;Evaluation;Failure;Family suidae;Food Supply;Formulation;Genome;Genomic Segment;Genotype;global health;helicase;Hepatitis E virus;Hepatocyte;hepatoma cell;HIV;Human;Human Cell Line;human pathogen;Immunocompromised Host;Immunosuppression;improved;improved outcome;Individual;Infectious Pregnancy Complications;innovation;insight;Laboratories;lipid nanoparticle;Liver;Malignant Neoplasms;Methyltransferase;mortality;nanoparticle;nanoparticle delivery;new technology;novel;novel therapeutics;nuclease;nucleic acid delivery;Nucleic Acid Regulatory Sequences;nucleic acid-based therapeutics;Nucleic Acids;Open Reading Frames;Organ;organ transplant recipient;organ transplant rejection;overexpression;pathogen;Patient-Focused Outcomes;Patients;Persons;Population;Populations at Risk;porcine model;Pregnancy;Pregnant Women;prevent;promoter;Proteins;Public Health;Quantitative Reverse Transcriptase PCR;rational design;remediation;Reporting;Resistance;response;Ribavirin;Risk;Risk Factors;RNA;RNA Viruses;RNA-Directed RNA Polymerase;Sampling;Single Nucleotide Polymorphism;Site;Solid;stem;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Uses;therapeutically effective;tool;Transcriptional Regulation;transmission process;Treatment Failure;Untranslated RNA;uptake;vaccine development;Vaccines;Validation;Viral Genome;Viral hepatitis;Viral Pathogenesis;viral RNA;virucide;Virus;virus culture;Virus Diseases;Virus Replication;Western Blotting;Zoonoses

PROJECT_TITLE: Evaluation of nanoparticle delivered CRISPR/Cas13-targeting hepatitis E virus as a therapeutic

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: DAR-ES-SALAAM

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: IFAKARA HEALTH INSTITUTE

PHR: Title: Improving dog vaccinations: a development and feasibility study to pave the way for effective, synchronized dog vaccination campaigns in Africa Despite dog-mediated human rabies can be eliminated through mass dog vaccinations, dog vaccinations have not been scaled-up in Africa, whereby, pilot campaigns conducted through a standard centralized team-led delivery have sometimes failed to achieve the required (70%) level of coverage that is necessary to interrupt rabies transmission. There is a lack of practical and evidence-based methods for scaling-up dog vaccinations to support global target set for elimination of human deaths by 2030, therefore, I will conduct implementation trial of synchronized mass dog vaccinations supported by mass media, to answer key questions related to the coverage, cost per dog vaccinated, and human health impacts of synchronized vaccination campaigns versus team-led delivery. I anticipate that this study will lay ground for future scale up of mass dog vaccination in East Africa and potentially other settings in sub-Saharan Africa.

PI_NAMEs: MAGANGA, SAMBO  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Africa;Africa South of the Sahara;alcohol tobacco and other drug use;arm;Asia;Authorization documentation;Bite;Brazil;Canis familiaris;Case Fatality Rates;Case Study;Cessation of life;Cold Chains;Communities;Complement;Consumption;cost;Country;Development;Devices;Disease;Drops;Effectiveness;effectiveness testing;Electricity;Event;evidence base;experience;Feasibility Studies;Filarial Elephantiases;Future;Geographic Locations;Geography;Grant;Health;heart disease risk;Human;Human Resources;Immunization;Immunization Programs;implementation trial;improved;Individual;Interruption;Intervention;Investigation;Latin America;Lead;Leprosy;Mass Media;Media Campaign;Media Intervention;Mediating;Methods;neglected tropical diseases;Outcome;Output;Persons;Peru;Pharmaceutical Preparations;Poliomyelitis;Population;prevent;Public Health;public health intervention;Rabies;Rabies Vaccines;Randomized;Randomized, Controlled Trials;Reporting;Research;Resource Allocation;Risk Behaviors;Risk Factors;Rural;Rural Community;scale up;Schedule;sex;Tanzania;Testing;Time;transmission process;university student;Vaccinated;Vaccination;Vaccines;Work;World Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Despite the importance of early diagnosis, genetic and molecular mechanisms of esophageal squamous cell cancer (ESCC) initiation remain elusive. The proposed research will elucidate the dual role, both autonomous and non-autonomous, of preneoplastic cells in driving ESCC development, which is expected to establish a novel foundation to develop new types of ESCC detection and treatment. Therefore, this study is related to public health and to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: KO, KYUNG PIL  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Ablation;Apoptosis;Automobile Driving;Bar Codes;Basal Cell;Biological Markers;Biological Models;Biology;cancer cell;cancer initiation;cancer stem cell;Cancerous;Carcinogens;CDKN2A gene;Cell Death;Cell Lineage;Cell Reprogramming;Cells;Characteristics;chemokine;Classification;Coculture Techniques;Copy Number Polymorphism;Creativeness;cytokine;Cytokine Gene;Data;Data Set;Detection;Development;Early Diagnosis;Early treatment;Educational process of instructing;Epithelium;Esophageal Neoplasms;esophageal squamous cell cancer;Esophageal Squamous Cell Carcinoma;Esophageal Tissue;Esophagus;Exhibits;experimental study;Family member;Fibroblasts;Fostering;Foundations;Frequencies;Genes;Genetic;genetic analysis;Genetic Engineering;Genetically Engineered Mouse;Goals;Health protection;Histologic;Human;Immune;Immune Evasion;Inflammation;innovation;Invaded;Knock-out;Knowledge;Lamina Propria;Lesion;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;Mentors;Mesenchymal;Mission;Modeling;Molecular;Molecular Analysis;mouse genetics;mouse model;Mus;Neoplasm Metastasis;Neoplasms;neoplastic;neoplastic cell;Normal tissue morphology;novel;Organoids;Outcomes Research;Patients;Phase;Phenotype;Play;Population Analysis;Predisposition;preneoplastic cell;Probability;Process;Prognosis;Proliferating;Public Health;Research;Research Personnel;Role;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;spatiotemporal;stemness;Survival Rate;Symptoms;Techniques;Testing;TP53 gene;Training;transcriptome;tumor;tumor microenvironment;tumorigenesis;Tumorigenicity;United States National Institutes of Health;Writing

PROJECT_TITLE: Esophageal squamous cell cancer initiation and immune landscape remodeling

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative No Changes from Parent Award

PI_NAMEs: GUPTA, DINESH  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Biological Models;cytochrome c;Methane Metabolism Pathway;Methanosarcina;parent project;Role

PROJECT_TITLE: Developing Methanosarcina spp. as a model system to study cytochromes c and their role in archaeal methane metabolism


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative The majority of modern women are exposed to reduced light quality from extended time spent indoors, employment requiring nighttime work, and nighttime technology use, leading to numerous health risks, including reproductive deficits. This basic science proposal will validate a diurnal rodent model to elucidate both individual and combined contributions of photoperiod- and light intensity-driven adaptations in the female reproductive axis. This work will determine the impact of light quality on trace element and neuroendocrine mechanisms modulating fertility and in vitro fertilization success.

PI_NAMEs: YAW, ALEXANDRA MARIE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Affect;Age;American;Animal Model;Assisted Reproductive Technology;Basic Science;career;Cells;circadian;Circadian Rhythms;Contraceptive methods;Coupled;Cues;Darkness;Data;Development;embryo culture;embryo quality;Embryonic Development;Employment;Exhibits;Exposure to;Female;female fertility;Fertility;fertility improvement;Fertilization;Fertilization in Vitro;Future;Goals;Health;Hormones;Human;hypothalamic pituitary ovarian axis;Hypothalamic structure;implantation;improved;in vitro Model;Individual;Infertility;insight;Investigation;Ireland;Lasers;Life;Light;light intensity;Lighting;Link;Maps;mass spectrometer;Mentors;Modeling;Modernization;Morphology;Neurons;Neurosecretory Systems;novel;oocyte quality;oocyte retrieval;Outcome;Ovarian;Ovary;Ovulation;Pathway interactions;Photoperiod;Phototherapy;Physiological Processes;Physiology;Pituitary Gland;Plasma;Play;Poaceae;Population;Positioning Attribute;Pregnancy;prevent;Property;Rattus;Reproduction;reproductive;reproductive axis;reproductive hormone;reproductive success;reproductive system disorder;Research;Research Personnel;response;Risk;Rodent;Rodent Model;Role;Seasons;Serum;Stains;success;Superovulation;Supplementation;System;Technology;Therapeutic Intervention;Time;time of flight mass spectrometry;Trace Elements;Training;Urine;Validation;Variant;Woman;Work;Zinc

PROJECT_TITLE: Novel Diurnal Model for In Vitro Fertilization Studies

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Unlike in adults, febrile urinary tract infection in children can be a silent and dangerous condition because it is challenging to diagnose with potential risk of progression to severe infection and permanent loss of kidney function. This proposal seeks to minimize the risk by implementing a practical, validated machine-learning algorithm to promptly identify unsafe anatomy before injury occurs. The result of this proposed machine- learning implementation is expected to open the horizon and be scaled to other institutions, ultimately facilitating interactive improvements in the algorithm and decision support suitable for wide adoption in diverse contexts.

PI_NAMEs: WANG, HSIN-HSIAO SCOTT (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Machine-learning prediction model for personalized urinary tract infection care in children

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Focal cortical dysplasia (FCD) is a common cortical malformation associated with medically refractory epilepsy and most frequently caused by variants in subunits of the GATOR1 complex (a negative regulator of mTOR): DEPDC5, NPRL3, and NPRL2. The least studied of these variants is NPRL2 and in this proposal we aim to define the pathophysiological consequences of Nprl2 KO in vivo and in vitro. Using a mouse model of FCD we will define the morphological and functional changes that occur due to Nprl2 KO-induced mTOR pathway hyperactivation as well as investigate the transcriptomic changes that occur downstream of mTORC1 that may produce MCD and seizures.

PI_NAMEs: IFFLAND, PHILIP HENRY (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;AKT3 gene;Amino Acids;Animals;Architecture;autism spectrum disorder;Binding;Biological Assay;brain malformation;brain tissue;Cell Aggregation;cell cortex;Cell Size;cell type;Cells;Cellular Morphology;Cerebral cortex;Childhood Neurological Disorder;Complex;Cortical Dysplasia;Cortical Malformation;CRISPR/Cas technology;Defect;Dendrites;Dependence;Development;Developmental Delay Disorders;differential expression;Disease;Dissociation;EIF4EBP1 gene;Electroencephalography;Electroporation;Ephrin-A5;Epilepsy;experimental study;Fluorescence;FRAP1 gene;Future;Genes;genetic variant;Growth;Harvest;Image;Image Cytometry;Immunochemistry;immunocytochemistry;in utero;In Vitro;in vivo;Individual;Intellectual functioning disability;Intractable Epilepsy;Knowledge;Lesion;Link;Lysosomes;Manuals;Measurement;Medical;Modeling;Monitor;Morphology;mouse model;mTOR Inhibitor;mTORopathies;Mus;Neurodevelopmental Disorder;neuronal cell body;Neurons;new therapeutic target;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;PIK3CG gene;Plasmids;pre-clinical;Precision therapeutics;preclinical study;Process;Protein Subunits;Proteins;Proto-Oncogene Proteins c-akt;pup;Regulator Genes;Resected;Resistance;response;Role;Seizures;Signal Transduction;single nucleus RNA-sequencing;Sirolimus;Somatic Mutation;Specimen;Starvation;STAT3 gene;Structure;Testing;transcriptome;transcriptomics;TSC2 gene;Variant;Western Blotting

PROJECT_TITLE: The role of NPRL2 loss in focal cortical dysplasia


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Our overall goal is to develop a program at the University of Louisville (UofL), its healthcare partners and the urban and rural communities we serve to perform impactful collaborative clinical and translational research. We will also leverage existing UofL IDeA programs to positively impact the health outcomes of our populace (including the underserved) and to create an interactive professional development program that will create a pipeline for the next generation of clinical and translational investigators.

PI_NAMEs: KLEIN, JON  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Admission activity;Award;biological research;Biomedical Research;Biometry;Cancer Center;Cardiac;Cardiovascular Diseases;career;Caring;Center for Translational Science Activities;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Informatics;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Community Participation;Community Physician;Data Analyses;data management;Databases;design;Development;Diabetes Mellitus;Discipline;Disease;Educational workshop;Ensure;follower of religion Jewish;Foundations;Funding;Goals;Growth;Health;Healthcare;Healthcare Systems;Heart Diseases;Home;Hospitals;improved;Incidence;Industry;Inflammation;Infrastructure;Institution;Instruction;Investments;Kentucky;Lead;learning network;Malignant Neoplasms;Measures;member;Mentors;Mentorship;Metabolic Diseases;metropolitan;microbiome research;Monitor;Neurosciences;next generation;Nursing Research;Obesity;Outcome;outpatient facility;participant safety;Pathogenicity;Patients;Process;Program Development;programs;Public Health;recruit;Rehabilitation Centers;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural;Rural Community;Rural Population;Scientist;Strategic Planning;Stroke;Students;Testing;Toxicology;Training;translational health science;Translational Research;translational research program;translational scientist;Transplantation;Underserved Population;Universities;Urban Community;Urban Population;Vision;Workforce Development;workforce needs

PROJECT_TITLE: Louisville Clinical And Translational Research Center (LCTRC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (CD)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Accidents;Accountability;Achievement;Address;Admission activity;Award;Budgets;Cancer Center;Cardiac;cardiovascular health;Caring;Center for Translational Science Activities;Centers of Research Excellence;Chronic Disease;chronic liver disease;Chronic Obstructive Pulmonary Disease;citizen science;Clinical;clinical center;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Unit;Collaborations;Communication;Communities;community engagement;conflict resolution;Diabetes Mellitus;Educational Curriculum;Ensure;Environmental Health;Evaluation;Faculty;Feedback;flexibility;Funding;Goals;Health;health care availability;Healthcare;Hospitals;Human Resources;improved;Incidence;Individual;Infrastructure;innovation;Kentucky;Kidney Diseases;Lead;Malignant Neoplasms;Measures;Medical center;member;Mentorship;Metabolic Diseases;Methods;metropolitan;Monitor;Needs Assessment;Nervous System Disorder;Nervous System Trauma;novel;novel therapeutics;Patients;Performance;Policies;Program Evaluation;programs;Public Health;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural;rural area;Rural Health;Rural Population;Strategic Planning;Structure;Students;synergism;Technology;Time;Training;Translational Research;translational research program;Transplantation;Universities;urban area;Urban Population;wearable sensor technology;Work

PROJECT_TITLE: Administrative Core (AC)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: PALMER, KENNETH E (contact)

PROJECT_TERMS: acute care;Address;Award;base;care outcomes;career development;Center for Translational Science Activities;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community building;community engaged research;community engagement;Community Outreach;Competence;Credentialing;data management;Degree program;Dental Students;design;Development;Discipline;Doctor of Philosophy;Education;Educational workshop;Engineering;experience;Faculty;Funding;Future;Grant;Growth;Health;improved;innovation;Investigation;K-Series Research Career Programs;Kentucky;Medical Students;member;Mentors;Mentorship;Nursing Research;Outcome;Physicians;Policies;Productivity;professional students;programs;Research;Research Design;Research Personnel;Research Project Grants;Scholars Program;Science;Scientist;Secure;skill acquisition;skills;Students;success;Time;Training;Training Programs;Translating;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Professional Development (PD) Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KONG, MAIYING  (contact)

PROJECT_TERMS: Area;Basic Science;Bioinformatics;Biometry;Biostatistics Core;Cancer Center;Center for Translational Science Activities;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Clinical Trials Unit;Collaborations;community engagement;Community Outreach;Competence;Consultations;Data Analyses;data management;Data Set;data warehouse;Databases;Dedications;design;Development;Educational workshop;electronic data;Electronic Health Record;Ensure;Experimental Designs;Faculty;Fostering;Funding;Grant;Health;Health protection;Health Resources;Human Subject Research;improved;Individual;Institution;interdisciplinary collaboration;Journals;Leadership;Learning;Medical;member;Mentorship;Methodology;Patient Care;Policies;population health;Population Study;professor;programs;Publications;Records;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Risk Management;Talents;Training;Training Activity;Translational Research;translational scientist;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Research Design, Compliance, and Data Management (RDCD)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: MCCLAIN, CRAIG J. (contact)

PROJECT_TERMS: Affect;Applications Grants;Award;career development;Center for Translational Science Activities;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Unit;Collaborations;Communities;community engaged research;community engagement;Community Outreach;data management;design;Development;Disease;Ensure;Ethics;experience;Extramural Activities;Funding;Future;Goals;Grant;Grant Review Process;health disparity;Health Priorities;Health Resources;improved;innovation;Institution;Investigation;investigator training;Link;Mentors;Monitor;next generation;Paper;participant safety;Persons;Pilot Projects;Population;Productivity;programs;Quality of life;Recommendation;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Subjects;Research Support;Resources;Scientist;Secure;Series;Testing;Training;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Health Resources (HR) Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: DUNN, KELLI MATHESON BULLARD (contact)

PROJECT_TERMS: Address;Awareness;base;Cardiometabolic Disease;Cardiovascular system;Center for Translational Science Activities;Chronic Disease;citizen science;Clinic;Clinical;Clinical Investigator;Clinical Research;combat;Communities;community academic partnership;community based participatory research;community building;community engagement;Community Health;community involvement;Community Outreach;community partners;cultural competence;Data;design;education research;Ensure;experience;Goals;Health;Health behavior;Health education;health literacy;Healthcare;Household;Improve Access;improved;innovation;Intervention;Investments;Kentucky;Knowledge;Lung;Malignant Neoplasms;Medical;Metabolic;Modality;Obesity;Outcome;Participant;Personal Satisfaction;Physicians;population health;Poverty;prevent;Prevention;programs;Reduce health disparities;Research;Research Methodology;Research Project Grants;research study;Resources;Risk;Rural;Smoking;socioeconomics;Subgroup;Training;Translating;Translational Research;Trust;Universities;Vision;Work

PROJECT_TITLE: Community Engagement and Outreach (CEO) Core


ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative Cells require their actin cytoskeleton to divide, move, and communicate with their environment. This project will reveal novel mechanisms of how actin monomers, the basic subunit the actin cytoskeleton, control the assembly and organization of actin structures in the cell. Deciphering these fundamental mechanisms could explain why defects in monomer regulation are associated with human diseases such as neurodegeneration, inflammatory disorders, cardiac disease and cancer.

PI_NAMEs: VITRIOL, ERIC A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Back;Behavior;Biochemical;Biochemistry;Biology;cell behavior;cell growth regulation;Cell Physiology;Cells;cellular imaging;Communication;Complex;Computer Models;Cytoskeleton;Defect;Disease;Environment;experimental study;Filament;Geometry;Heart Diseases;human disease;Image Analysis;Inflammatory;innovation;Knowledge;Malignant Neoplasms;monomer;Nerve Degeneration;novel;polymerization;Polymers;Proteins;quantitative imaging;Regulation;Role;Structure;Subgroup;superresolution imaging;tool;Work

PROJECT_TITLE: Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin Dynamics


ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE In the first hours of development, the embryo undergoes rapid cycles of DNA replication followed by high-level transcription of sets of genes required for subsequent developmental processes. We will test the hypothesis that pioneer transcription factors like Zelda in Drosophila play a dual role, first to mark origins of DNA replication, then at those same sites, transcriptional activation. Our findings will have broad implications for pioneer factors in coordinating developmental events in more complex organisms.

PI_NAMEs: RUSHLOW, CHRISTINE A (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Binding;Blastoderm;Body Patterning;Chromatin;Complex;Development;Developmental Process;DNA biosynthesis;DNA replication origin;Drosophila genus;Embryo;Enhancers;Event;Fertilization;gastrulation;gene network;Genes;Genetic Transcription;Genome;Goals;Hour;interest;Licensing;Mediating;Microscopy;Mitotic;Nucleosomes;Organism;origin recognition complex;Play;Pre-Replication Complex;Process;Replication Origin;Resolution;Role;Site;Testing;transcription factor;Transcription Initiation;Transcriptional Activation;transcriptome

PROJECT_TITLE: Pioneer factor activity in transcription and DNA replication

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cerebral small vessel disease is a major public health challenge and responsible for ~30% of strokes and at least 40% of dementia cases. This application will characterize cerebral microvascular pulsatility using two advanced MRI techniques on widely accessible 3T MRI, which may be a sensitive vascular marker of cSVD.

PI_NAMEs: YAN, LIRONG  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Affect;Alzheimer's Disease;arterial spin labeling;Arteries;arteriole;Arterioloscleroses;Arteriosclerosis;Assessment tool;Basal Ganglia;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;Cerebral Amyloid Angiopathy;cerebral artery;Cerebral endothelium;cerebral microbleeds;cerebral microvasculature;Cerebral small vessel disease;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrovascular Trauma;Cerebrum;Clinical;clinically relevant;Cortical vasculature;cost;Data;Dementia;Deposition;Deterioration;diagnostic technologies;Disease;Electrocardiogram;endothelial dysfunction;Endothelium;Epidemiology;Extravasation;Functional disorder;functional status;Goals;hemodynamics;Human;Image;imaging approach;imaging biomarker;Imaging Device;Impaired cognition;indexing;Infarction;Injury;Intercellular Fluid;Knowledge;Leptomeninges;Link;Liquid substance;Lobar;magnetic field;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Methods;millimeter;neuroimaging;novel diagnostics;Participant;Pathogenesis;Pathologic Processes;Pathology;Penetration;Perforating Artery;Phase;Physiological;Play;Prevention;Public Health;Radial;reconstruction;Reproducibility;Research;Research Project Grants;Resolution;Role;shear stress;Stroke;Structure;Surface;Techniques;Testing;Tissues;Vascular Cognitive Impairment;Vascular Diseases;vascular injury;Visualization;Waste Products;White Matter Hyperintensity;Work

PROJECT_TITLE: Imaging of cerebral microvascular pulsatility in cerebral small vessel disease

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases;Natural Products

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative The Centers for Disease Control and Prevention has stated that antimicrobial resistant infections claim more than 35,000 lives each year in the United States and increase the risks of organ transplants and cancer treatments. As antimicrobial resistance continues to spread, developing new antimicrobials is important to maintain effective treatments against antibiotic resistant bacteria. This project aims to understand how organisms naturally synthesize a newly discovered class of antimicrobials to advance future development and manufacturing efforts.

PI_NAMEs: DICKEY, SETH WAYNE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: alpha helix;Anabolism;anti-microbial peptide;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;bacterial genetics;Biochemical;biochemical model;Biological Assay;Biomedical Engineering;cancer therapy;Cellular Membrane;Centers for Disease Control and Prevention (U.S.);Clinical Research;cost;cost effective;cytotoxic;Cytotoxin;Data;design;Development;Drug resistance;effective therapy;empowerment;Engineering;Equilibrium;Event;Evolution;Exhibits;Family;Feedback;fitness;Future;Gene Cluster;Gene Expression Regulation;gene product;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Transcription;Genome;Goals;Gram-Positive Bacteria;Helix-Turn-Helix Motifs;Immunity;improved;Infection;insight;Instruction;interest;Investments;Knowledge;loss of function;loss of function mutation;manufacture;Maps;Measures;Membrane;Membrane Proteins;Methods;microbial genomics;Mining;Modeling;Molecular Biology Techniques;mutant;natural antimicrobial;Natural Products;novel;Operon;Organ Transplantation;Organism;Peptides;preclinical study;prevent;Process;Production;Property;Quantitative Reverse Transcriptase PCR;Regulation;Research;Resources;response;Ribosomes;Risk;Role;Source;Staphylococcus aureus;stem;Structure;System;Testing;Therapeutic;therapeutic development;transplantation therapy;United States;Variant

PROJECT_TITLE: Expanding the biosynthetic mechanisms of natural antimicrobial peptides

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The goal of this proposal is to prepare the candidate with the skills to successfully run a lab at the forefront of single-cell cross-modality translation. The research proposal will result in novel computational methods and software that can provide comprehensive multi-omics views of single cells. These tools will help us understand cellular processes such as cell differentiation during embryonic development and cancer.

PI_NAMEs: ZHANG, RAN  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: access restrictions;Advisory Committees;Algorithms;Atlases;autoencoder;Biological;Biological Assay;Cell Differentiation process;cell fate specification;cell growth regulation;Cell Physiology;Cells;Chromatin;Committee Members;complex biological systems;Computer software;computerized tools;Computing Methodologies;cost;Data;data integration;data modalities;Data Set;design;Detection;Development;developmental disease;Developmental Process;Disease;Disease Progression;Dissociation;Embryo;Embryonic Development;Environment;experimental study;extracellular;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Transcription;genome-wide;Genomics;Goals;graph neural network;Human;human embryonic development;Image;improved;individual patient;insight;Joints;Knowledge;Learning;Location;Machine Learning;machine learning method;machine learning model;Malignant Neoplasms;Maps;Measurement;Mediating;Mediator;Membrane Proteins;Mentorship;Methods;Modality;Modeling;multimodal data;multimodality;Multiomic Data;multiple omics;Mus;Mutation;novel;predictive tools;Process;Property;protein biomarkers;Proteins;Proteome;Proteomics;public database;Regulation;Research;Research Proposals;Resolution;Resources;Running;Sampling;Scheme;Series;sex;Sex Differences;Signal Pathway;single cell ATAC-seq;single cell genomics;single cell proteins;single-cell RNA sequencing;skills;spatiotemporal;Stimulus;supervised learning;Technology;Time;Time Factors;tool;Training;Training Programs;transcriptome;transcriptomics;transfer learning;Translating;Translations;Universities;Washington

PROJECT_TITLE: Semi-supervised cross-modality translation for single-cell genomics and proteomics

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Neurological impairment causes Alzheimer’s disease, an ever-increasing health burden. Stimulating adult neurogenesis, a process of generating new neurons by stem cells in the hippocampus, can serve as a therapeutic target for resisting cognitive impairment and promoting synaptic resilience against the disease.

PI_NAMEs: CHOI, SE HOON  (contact);HIDE, WINSTON ALEXANDER

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;Adult;adult neurogenesis;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein;Autopsy;Behavior;behavior test;Bioinformatics;Birth;Brain;brain tissue;Brain-Derived Neurotrophic Factor;candidate identification;Cell Line;Cell model;Cell Nucleus;cell type;Cells;Cognition;Cognitive;cognitive function;Combined Modality Therapy;Compensation;Complex;Dementia;dentate gyrus;Disease;Drops;drug development;Environment;Event;Exercise;Fibronectins;Genetic;granule cell;Health;Hippocampus;Human;human subject;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Interleukin-6;knock-down;Knock-in Mouse;Life;Maps;Mediating;Memory impairment;Memory Loss;mild cognitive impairment;Modeling;Molecular;molecular marker;Molecular Profiling;Morphology;mouse model;Mus;Natural Compound;Nature;Nerve Degeneration;nerve stem cell;neurofibrillary tangle formation;Neurofibrillary Tangles;neurogenesis;neuroinflammation;Neurologic;neuron loss;Neurons;neuropathology;neuroprotection;Neurosphere;non-demented;novel;overexpression;Pathogenesis;Pathologic;Pathology;Patients;pharmacologic;Pharmacological Treatment;Population;preservation;Primary Cell Cultures;Process;promote resilience;Proteins;Receptor Protein-Tyrosine Kinases;Recovery of Function;resilience;Resolution;response;RNA;Role;Senile Plaques;single nucleus RNA-sequencing;Synapses;tau Proteins;Tauopathies;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutic target;Tissues;transcriptomics;treatment strategy;Validation;Work

PROJECT_TITLE: Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE Neurons can communicate with each other via electrical and chemical signals, as well as membrane-bound packets called extracellular vesicles. These vesicles carry cargo that can contribute to normal brain function, but in neurological disorders including Parkinson’s and Alzheimer’s Diseases, they can also spread toxic proteins throughout the brain. Our research will help us understand how extracellular vesicles are packaged, released and spread in the nervous system, and may identify new strategies to treat a wide variety of neurological diseases.

PI_NAMEs: RODAL, AVITAL ADAH (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;Alzheimer's Disease;Behavior;Binding;Biochemistry;Biogenesis;Brain;Carrier Proteins;Cell membrane;cell type;Cells;Cellular Membrane;Chemicals;Clathrin;Communication;Complex;Data;Defect;Disease;Drosophila genus;Endocytosis;Endosomes;Event;experimental study;extracellular vesicles;Foundations;Genetic;genetic approach;Goals;Human;imaging approach;in vivo;insight;intercellular communication;Knowledge;Link;Lipids;live cell imaging;Mediating;Membrane;Membrane Protein Traffic;Microscopy;Monitor;Morphogenesis;Morphology;mutant;Nature;Nerve;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;Neurons;novel;Nucleic Acids;optogenetics;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Phosphotransferases;Physiological;Plasma;Play;Population;presynaptic;Presynaptic Terminals;Process;Proteins;rab11 protein;Receptor Signaling;Recycling;Regulation;Research;Resolution;response;retrograde transport;Role;Route;scaffold;Signal Transduction;Sorting;Synapses;Synaptic Membranes;Synaptic Transmission;SYNJ1 gene;Testing;Therapeutic;tool;trafficking;Vesicle;vesicular release;Work

PROJECT_TITLE: Roles of Recycling Endosomes in Neuronal Extracellular Vesicle Cargo Traffic

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The clinical sepsis syndrome occurs due to an overwhelming inflammatory response to an infection, and requires aggressive treatment. Sepsis is beset with very high mortality due to vasoplegia, a physiologic condition in which blood vessels do not work and fail to perfuse vital organs such as the lung. Using a robust porcine model of fecal peritonitis (fecal clot with ischemia-reperfusion injury) to recapitulate human disease, the proposed research will quantify physiologic impairment in vascular smooth muscle and endothelial cells, and explore concomitant dysregulation of “off-signaling” of harmful intracellular events as a putative mechanism.

PI_NAMEs: WISE, ERIC STEPHEN (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Adhesions;Advisory Committees;aggressive therapy;Animal Model;Apoptosis;Area;Arteries;Automobile Driving;Bathing;biobank;Biochemical;Biochemistry;biological adaptation to stress;Biological Availability;Blood flow;Blood Platelets;Blood Vessels;career;career development;Catecholamines;cell injury;Cell Physiology;Cells;Cellular biology;Cessation of life;Clinical;Coagulation Process;Complex;cytokine;Data;Development Plans;Effectiveness;Electric Capacitance;Emergency Situation;endoplasmic reticulum stress;Endosomes;Endothelial Cells;endothelial dysfunction;Endothelium;Euthanasia;Event;Extracellular Matrix;Family suidae;Functional disorder;Funding;Glycocalyx;Goals;Harvest;hemodynamics;Hour;Human;human disease;hypoperfusion;Hypotension;Hypoxia;Image;Impairment;improved;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;insight;Institution;Intention;Intercellular Junctions;Interleukin-1 beta;Intravenous;intravital imaging;intravital video microscopy;Ischemia;Laboratories;Learning;lens;Leukocytes;Life;Liquid substance;Lung;MAP Kinase Gene;Medical emergency;meetings;Mentors;Mentorship;Mesentery;Microcirculatory Bed;Microscopy;mimetics;Minnesota;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;Mus;Muscle;Muscle Cells;novel strategies;Operative Surgical Procedures;Organ;Organ failure;Oxygen;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Patient Care;Pattern;Penetration;Peptides;Perfusion;Peripheral;Peritonitis;Permeability;Pharmaceutical Preparations;Phosphorylation;Phosphoserine;Phosphotransferases;Physiological;Physiology;porcine model;Positioning Attribute;prevent;primary outcome;programs;protein aminoacid sequence;protein expression;Proteins;Pulmonary vessels;rational design;Rattus;Regulation;Relaxation;Reperfusion Injury;Research;Research Technics;response;Resuscitation;Role;Scientist;Sepsis;Sepsis Syndrome;septic;Septicemia;Severities;Shock;Signal Induction;Signal Pathway;Signal Transduction;small molecule;Smooth Muscle Myocytes;Stains;Stretching;success;Surgeon;Surgical Models;systemic inflammatory response;Techniques;Testing;Therapeutic;therapeutic target;Tissues;tool;Translating;Universities;vascular injury;Vascular Smooth Muscle;Vascular System;vasoconstriction;Vasodilation;Veins;Venous system;Video Microscopy;viscoelasticity;Visualization;Work

PROJECT_TITLE: The Physiology and Biochemistry of Sepsis-induced Vasoplegia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: We will use a type 1 hybrid study to evaluate efficacy and implementation/adoption considerations for MI- CHANCE, a peer-led motivational interviewing (MI) intervention to promote uptake of drug checking services (DCS) and safer drug use behaviors among people who use drugs (PWUD) to reduce incidence of overdose (OD) in San Diego County. Through our two-arm randomized controlled trial, we hypothesize that PWUD who receive MI-CHANCE will be more likely to use DCS and experience significantly lower rates of OD relative to a control group over 30 months of follow-up; we will use qualitative methods to explore local implementation experiences and potential adoption by other SSPs across the country. Our bilingual/bicultural intervention will leverage the infrastructure of an ongoing cohort of PWUD, involves a collaborative team including local harm reduction community and government partners and is designed to be both practical and scalable.

PI_NAMEs: BORQUEZ, ANNICK ;STRATHDEE, STEFFANIE A. (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 2 arm randomized control trial;Adoption;Adult;Age;arm;attentional control;Behavior Therapy;behavioral outcome;bilingualism;California;Client;Clinical Trials Network;cohort;Communities;comparative efficacy;Control Groups;Counseling;Country;County;COVID-19;Data;design;Disparity;Drug Evaluation;Drug usage;drug use behavior;Drug user;Education;Effectiveness;efficacy evaluation;efficacy testing;Empirical Research;empowerment;Ethics;ethnic disparity;Expectancy;experience;Fentanyl;follow-up;Fourier transform infrared spectrometry;Frequencies;Government;Habits;Harm Reduction;harm reduction programs;Helping to End Addiction Long-term;Heroin;hybrid type 1 study;Illicit Drugs;implementation cost;implementation evaluation;implementation framework;implementation intervention;implementation trial;improved;Incidence;Infrastructure;innovation;interest;Intervention;intervention effect;Knowledge;Latinx population;Legal;Letters;Location;manufacture;Mediating;Mediation;Mediator;meetings;Methamphetamine;Mexican;Modeling;motivational enhancement therapy;naloxone dispensing;National Institute of Drug Abuse;Needle-Exchange Programs;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Overdose;overdose death;overdose education;overdose prevention;Overdose reduction;Participant;peer;Persons;Pharmaceutical Preparations;Pharmacy facility;pill;Policy Maker;primary outcome;Professional counselor;Public Health;Qualitative Methods;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;response;Risk;Sampling;secondary outcome;Self Efficacy;service programs;service uptake;Services;Site;social;social cognitive theory;Speed;standard of care;structural determinants;Technology;test strip;Testing;theories;Time;Training;treatment arm;United States National Institutes of Health;uptake;Work;Xylazine

PROJECT_TITLE: Efficacy and implementation considerations for a peer-led motivational interviewing intervention to promote uptake of drug checking services and safer drug use behaviors to reduce overdose

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Physical Activity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The rising prevalence of mental illness and its significant contribution to maternal morbidity and mortality necessitate the development of feasible, scalable, and effective interventions. This proposal is a first step towards addressing this problem by focusing on reducing the risk of severe maternal morbidity (SMM), which precedes most maternal deaths, in people with mental illness. In addition to elucidating the complex pathways underlying the association between mental illness and SMM, this proposal will also pilot an intervention to treat psychobiological aspects of mental illness with the goals of reducing SMM on a larger scale and driving innovative and impactful research in maternal and child health for years to come.

PI_NAMEs: PANELLI, DANIELLE MARI (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 37 weeks gestation;access disparities;Accounting;actigraphy;Address;Adherence;Affect;antenatal;antepartum depression;Anxiety;Area;arm;Automobile Driving;Behavioral;Biological;biological adaptation to stress;Biological Markers;career;career development;Caring;Cessation of life;Clinical;Clinical Trials;comorbidity;Complex;Data;Databases;Development;Devices;Disparity;effective intervention;Emotional;Epidemiologic Methods;Epidemiologist;Equity;Event;Exercise;exercise intervention;experience;Face;formal learning;Goals;Graph;Hair;Health;health disparity;Hydrocortisone;improved;Inflammation;innovation;Intervention;Knowledge;Length;Leukocytes;Life;lifestyle factors;lifestyle intervention;Link;marginalized community;Maternal and Child Health;maternal morbidity;Maternal Mortality;Mediator;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Metabolic;Methodology;Modeling;mortality;National Institute of Child Health and Human Development;Outcome;Outcomes Research;Participant;Pathway interactions;Patient Preferences;Perinatal;Persons;Pharmaceutical Preparations;Physical activity;Population;Population Analysis;Population Heterogeneity;Postpartum Depression;Postpartum Period;Pregnancy;Pregnancy Complications;pregnant;Prevalence;Prevention strategy;programs;psychobiologic;Psychologist;Public Health;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk;Risk Reduction;Scientist;secondary outcome;Services;severe maternal morbidity;Severities;Severity of illness;social stigma;Socioeconomic Factors;socioeconomics;Strategic Planning;Stress;stress reduction;substance use;Survivors;Symptoms;Target Populations;telomere;Testing;Training;treatment strategy;trend;trial design;United States;Veterans Health Administration;Walking;Work;Wrist

PROJECT_TITLE: Leveraging psychobiologic markers of stress to reduce severe maternal morbidity in pregnant people with mental illness

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]