ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Mental Health;Mental Illness;Pain Research;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative: The goal of this K01 proposal is to provide critical training in integrative oncology research methods, implementation science, and medical informatics, and to evaluate the feasibility and acceptability of a chaplain-delivered meditation program for patients receiving hematopoietic stem cell transplant. The proposed research will accelerate progress toward evidence-based intervention strategies embedded in clinical settings to address depression and pain distress during cancer treatment and to improve long-term quality of life for cancer survivors.

PI_NAMEs: MASCARO, JENNIFER STREIFFER (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Address;Admission activity;Adoption;Adult;Advanced Malignant Neoplasm;Affect;Aftercare;aggressive therapy;Anxiety;Attenuated;Autologous;Award;base;Biological;Breast Cancer survivor;cancer care;Cancer Patient;Cancer Survivor;cancer therapy;career;career development;Chaplain;chemotherapy;Client satisfaction;Clinical;clinical care;Clinical Services;clinically relevant;Cognitive;Collaborations;Compassion;Consolidated Framework for Implementation Research;Control Groups;Data;depressed patient;depressive symptoms;Deterioration;Diagnosis;Distress;Education;efficacious treatment;Eligibility Determination;Emotional;Enrollment;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Fatigue;Feasibility Studies;Focus Groups;Goals;Health;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hospitalization;Hospitals;implementation barriers;implementation science;improved;Inflammatory Response;Inpatients;Instruction;Integrative Therapy;Intervention;Intervention Trial;Leadership;Loneliness;Longterm Follow-up;Low income;Malignant lymphoid neoplasm;Measures;Medical Informatics;Medical Oncologist;Meditation;Mental Depression;Mentors;Methods;Mind-Body Intervention;mind/body;mindfulness;Modality;mortality;National Center for Complementary and Integrative Health;novel;novel strategies;Nurses;Oncology;Outcome;Pain;Pain management;Patient Outcomes Assessments;patient population;patient screening;Patients;Personal Satisfaction;physical symptom;Play;Population;post intervention;post-transplant;Privacy;programs;Provider;psychologic;Psychoneuroimmunology;psychosocial;Psychosocial Stress;psychosocial wellbeing;Quality of life;quality of life for cancer survivors;racial population;Randomized;reduce symptoms;Religion;Reporting;Research;Research Methodology;Research Personnel;research study;retention rate;Risk;Role;satisfaction;Science;Self Administration;Self Perception;side effect;Site;Sleep disturbances;social;Spiritual care;Spirituality;standard of care;Stem cell transplant;stem cells;Strategic Planning;stressor;Structure;success;Surveys;Survival Rate;system-level barriers;theories;Time;Toxic effect;Training;Transplantation;treatment as usual;trial comparing;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: A Feasibility Study of Chaplain-Delivered Compassion Meditation for Patients Receiving Stem Cell Transplantation


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases;Microbiome

ORG_CITY: MEMPHIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The purpose of this project is to develop a new, more effective, and selective antibiotic to treat H. pylori infection, which causes chronic inflammation of the stomach lining, ulcers, and cancer.

PI_NAMEs: LAFLEUR, MICHAEL ;LEE, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Amoxicillin;antagonist;Anti-Bacterial Agents;Antibiotics;Attention;Bacteria;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Availability;Caco-2 Cells;Carcinogens;Categories;Cell Membrane Permeability;Cells;Chemistry;Chronic;chronic infection;Clarithromycin;Collection;combat;Complex;counterscreen;cytotoxicity;Databases;design;Development;drug development;Drug Kinetics;Drug resistance;drug resistant pathogen;druggable target;Epithelial Cells;experimental study;Feedback;Galactose;gastrointestinal;Genus Hippocampus;Glucose;Goals;Growth;gut microbiota;Helicobacter;Helicobacter Infections;Helicobacter pylori;Hepatocyte;Homology Modeling;Human;improved;in vitro Assay;in vitro testing;in vivo;in vivo Model;Inflammation;inhibitor;lead candidate;lead optimization;Ligands;Liquid substance;Malignant Neoplasms;malignant stomach neoplasm;Measures;Metronidazole;microbiome;Microsomes;Mitochondria;Modeling;Monitor;mutant;NADH dehydrogenase (ubiquinone);novel;novel therapeutics;Oral;Oxygen Consumption;pathogen;pathogenic bacteria;Peptic Ulcer;pharmacologic;Pharyngeal structure;Phosphotransferases;pre-clinical;priority pathogen;Property;Proton Pump Inhibitors;Reporting;resident commensals;Resistance;Resistance development;resistant strain;Respiration;scaffold;Series;Solubility;Stomach;Stomach Carcinoma;Stress Tests;Structure;synergism;Testing;Ulcer;virtual;virtual screening

PROJECT_TITLE: Targeting NuoD for the treatment of H. pylori

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: The ability to predict protein-peptide complex structures will have a far-reaching impact on understanding important biological processes and on designing therapeutic interventions. We propose to tackle the challenge of protein- peptide structure prediction, including developing the first in silico peptide screening method to dramatically save cost and time. We will screen for peptide inhibitors by targeting β-lactamase to combat antibiotic resistance.

PI_NAMEs: ZOU, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Antibiotic Resistance;Attention;beta-Lactamase;Biochemistry;Bioinformatics;Biological Process;Cell Physiology;Collaborations;combat;Communities;Complement;Complex;Computational algorithm;Computer Models;Computer software;cost;Cost Savings;deep learning;deep learning model;design;Disease;flexibility;Freedom;Goals;Immune response;in silico;inhibitor;innovation;Investigation;Ligands;Medicine;Methods;Microbiology;Molecular Biology;NMR Spectroscopy;novel;open source;peptide drug;Peptide Library;peptide structure;Peptides;Phage Display;physical model;protein data bank;protein structure prediction;Proteins;screening;Signal Transduction;Structure;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;Time;Transcriptional Regulation;X-Ray Crystallography;yeast two hybrid system

PROJECT_TITLE: Structure prediction and in silico screening of protein-peptide interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative There is a critical need to develop accurate genetic risk prediction models for non-European populations because most studies to date have focused on individuals of European ancestry. This project will propose novel statistical methods to integrate data from diverse populations for more accurate risk prediction models in the underrepresented populations. Our developed tools, their applications to many diseases, and the associated dissemination platform will facilitate the translation of genome wide association study results into clinically useful disease risk prediction models in these populations.

PI_NAMEs: ZHAO, HONGYU  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;analysis pipeline;Bayesian Method;Benchmarking;Clinical;cohort;Complex;Data;data integration;design;Diagnosis;Disease;disorder risk;European;European ancestry;experience;flexibility;Generations;Genetic;genetic architecture;Genetic Risk;genetic variant;Genome;genome wide association study;Goals;Heritability;High Performance Computing;Human Genome;improved;Individual;Joints;large datasets;Medical Genetics;Methods;Modeling;Monitor;novel;parallelization;Participant;Performance;Population;Population Analysis;Population Heterogeneity;Prevention;Procedures;Prognosis;Publishing;recruit;Reduce health disparities;Research;Research Personnel;Risk;risk prediction;risk prediction model;Sampling;simulation;Standardization;Statistical Methods;statistics;Structure;Time;tool;trait;Translating;Translations;Underrepresented Populations;user-friendly;Validation;Variant;web server;Work

PROJECT_TITLE: Statistical Methods for Genetic Risk Predictions across Diverse Populations

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Lung cancer screening (LCS) with low-dose computed tomography has significant potential to reduce overall lung cancer mortality and also mitigate long-standing racial/ethnic disparities in lung cancer mortality. However, LCS utilization has been limited, notably among Black individuals. The proposed study aims to provide a solid knowledge base about the multilevel factors that influence racial/ethnic disparities in LCS utilization, which will facilitate developing interventions that ensure the maximal benefits afforded by LCS are achieved and extended equitably in practice.

PI_NAMEs: SAKODA, LORI  (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Adult;Affect;Age;Attitude;Awareness;Behavior;Belief;Black Populations;Black race;cancer care;Clinical;Clinical Services;Continuity of Patient Care;Counseling;Data;Data Sources;Disease;Disparity;Disparity population;distrust;Documentation;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;follow-up;former smoker;Fostering;Health;Health care facility;Health Insurance;Health Personnel;Health Priorities;Health Services;Health system;Healthcare;high risk population;Household;implementation barriers;improved;Individual;Influentials;insight;insurance claims;Integrated Health Care Systems;Intervention;Knowledge;knowledge base;Language;Link;low dose computed tomography;lung cancer screening;Malignant neoplasm of lung;Measures;Medical;Medicare;Minority;mortality;multilevel analysis;Neighborhoods;outreach;Patient Self-Report;Patients;Pattern;Pharmacotherapy;Population;Population Heterogeneity;Process;Provider;public health relevance;Questionnaires;Race;racial determinant;racial disparity;racial minority;racial population;Recommendation;Recording of previous events;Registries;Reporting;residence;Resources;screening;Screening for cancer;Services;sex;shared decision making;Smoke;Smoking;smoking cessation;Smoking History;social stigma;sociodemographics;Socioeconomic Status;Solid;stem;Surveys;Target Populations;Time;trend;Trust;United States Preventative Services Task Force;uptake;Visit;willingness;Work

PROJECT_TITLE: Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative A challenge facing understanding pathogenesis of SCA1, and neurodegenerative diseases in general, is elucidating the relative contribution of each molecular pathway altered has in pathogenesis in the different regions of the brain affected. We will - 1) Perform a molecular characterization of ATXN1[154Q] knockin induced pathogenesis  downstream of nuclear entry in regions/cell types other than cerebellar Purkinje cells. 2) Use a recently developed floxed ATXN1[146Q] mouse model to determine the  regional/tissue contributions to SCA1-ilke phenotypes. 3) Examine the extent to which manipulation of the Cholecystokinin - Cholecystokinin  1 Recptor pathway is a potential therapeutic target for treatment of SCA1, other  SCAs that involve Purkinje neuron degeneration and perhaps neurons in other  SCAs affected brain regions.

PI_NAMEs: ORR, HARRY T. (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Aging;Ataxia;ataxin-1;Atrophic;Brain region;Brain Stem;CAG repeat;cell type;Cerebellar Cortex;Cerebellum;Characteristics;Cholecystokinin;Deglutition;effective therapy;Equilibrium;Glutamine;Impaired cognition;Inherited;Knock-in;Late-Onset Disorder;LoxP-flanked allele;Mediator;Molecular;Molecular Genetics;Motor;mouse model;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Nuclear;Onset of illness;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phenotype;Physiological;protective pathway;Proteins;Purkinje Cells;Research;Signal Pathway;spasticity;Speech;Stretching;Symptoms;Therapeutic;therapeutic target;Tissues;Type 1 Spinocerebellar Ataxia

PROJECT_TITLE: Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspective


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: This Genome Characterization Center (GCC) will use state-of-the-art and novel procedures to discover and characterize somatic variation in 750 of the proposed 2,250 SmaHT tissues samples. The GCC will work closely with the SMaHT network to benchmark methods, develop standards and to harmonize data structures. A period of standardization and calibration will be followed by sustained production. Local analyses will enhance the value of the data and suggest models for the mutagenesis.

PI_NAMEs: DODDAPANENI, HARSHA VARDHAN;GIBBS, RICHARD A (contact);ZONG, CHENGHANG

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Aging;Benchmarking;Biological Assay;Biology;Calibration;Catalogs;Collaborations;college;Common Core;Communication;Data;Data Analyses;data exchange;data format;data harmonization;data repository;design;Detection;Development;Developmental Process;Disease;Ecosystem;Elements;Ensure;Epigenetic Process;Evaluation;Event;Future;Generations;Genetic;Genome;genome sequencing;genomic variation;Health;Human;human disease;human genome sequencing;human tissue;improved;Individual;insight;Knowledge;Laboratories;Life;Link;Malignant Neoplasms;Medicine;member;Methods;Modeling;Monitor;Mosaicism;Mutagenesis;Mutation;new technology;Nitrites;Normal tissue morphology;novel;Nuclear RNA;Pathogenicity;Pattern;Performance;Phase;Predisposition;Procedures;Process;Production;programs;Protocols documentation;Research Design;Research Personnel;Role;Sampling;sequencing platform;single nucleus RNA-sequencing;software development;Software Tools;Somatic Mutation;Standardization;Statistical Models;Structure;success;Technology;Testing;Tissue Sample;Tissues;tool;transcriptome sequencing;Validation;Variant;variant detection;web interface;whole genome;Work

PROJECT_TITLE: Comprehensive Somatic Variant Characterization at the HGSC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE CULLIN-RING E3 ubiquitin ligases (CRLs) represent the largest class of ubiquitin ligases and use more than 200 adaptor proteins to specific substrates. However, numerous gaps exist in our understanding of what determines the identity of targets of CRLs. We will employ powerful genetic and biochemical methods to reveal the architecture of the CRL system, including the identification of dozens of E3-target pairs and will elucidate how one subfamily of CRLs controls proteome remodeling during conversion of human ES cells to germ cell lineages

PI_NAMEs: HARPER, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adaptor Signaling Protein;Address;Aging;Architecture;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Biological Process;Biology;Cancer cell line;Catalytic Domain;Cell Cycle Regulation;Cell Lineage;Cells;Chemicals;CRISPR screen;Cues;Cullin Proteins;Data;Degradation Pathway;Development;Disease;Dissection;DNA Repair;embryonic stem cell;Eukaryota;expectation;Experimental Designs;Genetic;Genetic Transcription;genome-wide;Germ Cells;Guanine Nucleotide Exchange Factors;Human;human embryonic stem cell;human stem cells;Individual;insight;Knowledge;Libraries;Link;Methodology;Methods;MicroRNAs;Modification;Molecular;Mutagenesis;Mutation;novel;novel strategies;Nutrient;Open Reading Frames;Output;Pathway interactions;Phosphopeptides;Phosphorylation;Physiological;Physiology;Play;Process;protein aminoacid sequence;protein complex;protein degradation;Proteins;Proteome;Proteomics;Quality Control;response;Role;Signal Pathway;Signal Transduction;Specificity;stem cell differentiation;Stimulus;System;Techniques;Testing;TFE3 gene;transcription factor;transcriptome;ubiquitin ligase;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Validation;Work

PROJECT_TITLE: Ubiquitin‐mediated proteolysis and cell cycle control

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Natural Products;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The treatment of human disease, from viral infections to neurodegenerative conditions such as Alzheimer's disease, relies in large part on the discovery and development of new medicines for therapeutic intervention. This proposal seeks to develop new catalytic reactions to access known pharmacophores, diversify these scaffolds to make new derivatives for testing, and synthesize natural product families that exhibit significant neuroprotective effects to study them in greater detail. These methods will provide an increase in efficiency and generality for the synthesis of established drug molecules and promising new targets.

PI_NAMEs: MARTIN, DAVID  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Adamantane;Alcohols;Alzheimer's Disease;bioactive natural products;Biochemistry;Biological;catalyst;Chemicals;Clinical;Cobalt;Complex;Coupling;design;Development;Exhibits;Family;Goals;Guidelines;human disease;insight;Investigation;Light;Lipids;Medicine;Methods;natural product derivative;Natural Products;Nerve Degeneration;neuroprotection;novel;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;pharmacophore;Process;programs;Reaction;Reporting;Research;Research Personnel;scaffold;Technology;Terpenes;Testing;Therapeutic Intervention;Virus Diseases;Vitamin B 12

PROJECT_TITLE: New Photocatalytic Coupling Reactions to Prepare Bioactive Molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Kidney Disease;Lung;Pain Research;Patient Safety;Prevention;Pulmonary Hypertension;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: As patients with sickle cell disease live to adulthood, they are developing heart and lung disease that leads to  early death. Blood and heart ultrasound tests can identify patients at risk. In this clinical trial we will evaluate  whether monthly red blood cell transfusions can improve their symptoms and prevent hospitalization and death.

PI_NAMEs: GLADWIN, MARK T (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Accelerometer;Accident and Emergency department;Activities of Daily Living;Acute;acute chest syndrome;Adult;Adverse effects;Age;Aging;Alloimmunization;Antigens;autosome;beta Globin;beta Thalassemia;Biological Markers;Blood;Blood capillaries;Cardiac Catheterization Procedures;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cephalic;Cessation of life;Childhood stroke;Chronic;Chronic Kidney Failure;chronic pain;chronic stroke;Clinical;clinical research site;Clinical Trials;cohort;Cohort Studies;Consensus;Data;Death Rate;Deceleration;Development;Diagnosis;Disease;Disease Progression;disorder risk;Doppler Echocardiography;Echocardiography;Elderly;Erythrocyte Transfusion;Erythrocytes;Event;exercise capacity;experience;Failure;Functional disorder;functional loss;Genes;hazard;health related quality of life;Healthcare;Heart;Heart Diseases;Heart Injuries;Hemoglobin;Hemoglobin SS;Hemolytic Anemia;Hepatic;Heterozygote;high risk;Home;Hospitalization;Hospitals;improved;improved outcome;Infrastructure;Infusion procedures;inhibitor;Injury to Kidney;intervention effect;Iron;Laboratories;Left;Lung Diseases;lung injury;lung pressure;Measurement;Measures;Meta-Analysis;meter;Microalbuminuria;Morbidity - disease rate;mortality;mortality risk;Multiple Organ Failure;Multivariate Analysis;mutant;Myocardial dysfunction;Odds Ratio;Organ;organ injury;P-Selectin;Pain;Pathogenesis;Patients;Pattern;Pharmaceutical Preparations;Physiological;Plasma;Point Mutation;Polymers;Population;Premature Mortality;prevent;Prevention;pro-brain natriuretic peptide (1-76);Probability;Proteinuria;pulmonary arterial pressure;Pulmonary Hypertension;Pulse Pressure;Reaction;Recurrence;Registries;right ventricular failure;Risk;Risk Reduction;Safety;screening;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sildenafil;standard of care;Stroke;Stroke prevention;Sudden Death;Symptoms;Testing;therapeutic evaluation;Therapeutic Intervention;therapeutically effective;Transfusion;Treatment Efficacy;Ultrasonography;Universities;vaso-occlusive crisis;Ventricular;Visit;Walking;Whole Blood Exchange Transfusion

PROJECT_TITLE: Sickle Cell Disease and Cardiovascular Risk- Red Cell Exchange SCD-CARRE


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The goal of our research is to discover the mechanisms of visual computation in the retina. This proposal studies a novel circuit in two different types of retinal ganglion cells are electrically coupled. Our discovery of heterotypic coupling in retinal ganglion cells, the output cells of the retina, challenges a long-standing principle of functional parallelism, requiring new ideas about early stages of visual computation. This research will have impacts beyond the retina in revealing fundamental principles of neural circuit architecture and mechanism in line with the goals of the BRAIN initiative.

PI_NAMEs: SCHWARTZ, GREGORY WILLIAM (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Ablation;Affect;Architecture;Auditory system;Axon;Brain;BRAIN initiative;Brain region;cell type;Cells;Chemicals;Closure by clamp;Communication;Complement;Coupled;Coupling;design;Elements;Exhibits;experimental study;Gap Junctions;Glutamates;Goals;insight;Light;Mammals;Maps;Measures;Membrane Potentials;Mus;Names;neural;neural circuit;Neurons;Noise;novel;Output;Pathway interactions;Pattern;pharmacologic;Positioning Attribute;preservation;receptive field;Recurrence;Research;Resolution;response;Retina;Retinal Ganglion Cells;Role;Sensory;Signal Transduction;Site;Stimulus;Structure;Synapses;Techniques;Testing;Time;transmission process;Visual;voltage clamp;Work

PROJECT_TITLE: Functional consequences of heterotypic retinal ganglion cell coupling

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: NARRATIVE Research into human development requires the use of animal model systems that share many of the same developmental pathways as Homo sapiens. One important model system is Xenopus, the African clawed frog, which has been extensively used in developmental biology, cell biology, genetics, toxicology, and small molecule screens. The Cold Spring Harbor Laboratory short course on the Cell & Developmental Biology of Xenopus is an intensive two-week experience that provides up-to-the minute training in conceptual approaches and technologies using Xenopus as a model system. The course enables participants to immediately apply advanced techniques in Xenopus to their own research projects, to network with their research peers, and to learn through hands-on access to the latest available equipment and reagents.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Ablation;African;Animal Model;Applications Grants;Area;Biochemical;Biochemistry;Biological;Biological Models;Biological Process;biological research;Biology;Biomechanics;career;Cell Cycle Regulation;Cells;Cellular Assay;Cellular biology;Chemistry;Clutch Size;Communication;Communities;cost;Course Content;course introduction;Creativeness;Development;Developmental Biology;Developmental Process;Diploidy;Discipline;Dissection;Educational process of instructing;Embryo;Ensure;Equipment;experience;experimental study;Faculty;Generations;Genes;Genetic;genetic analysis;Genetic Techniques;Genomics;Goals;graduate student;Home;Homo sapiens;Human Development;Imaging Techniques;In Vitro;in vivo;innovation;Institution;Ion Channel;Laboratories;Learning;Medicine;Messenger RNA;mid-career faculty;Modeling;Modernization;Molecular;Molecular Analysis;Molecular Biology;next generation;Nobel Prize;Oocytes;Participant;Pathway interactions;peer;Postdoctoral Fellow;programs;Reagent;Research;Research Personnel;Research Project Grants;Research Technics;Resources;Scientist;small molecule;stem cell biology;Structure;Students;System;Techniques;Technology;Time;tool;Toxicology;Training;Underrepresented Minority;Update;Visualization;Woman;Work;Xenopus;xenopus development;Xenopus laevis

PROJECT_TITLE: CSHL Cell and Developmental Biology of Xenopus Course

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Disability Research;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE As a vascular neurologist and translational scientist, I am committed to advancing cardiovascular health for both men and women. My research has focused on elucidating the fundamental mechanisms responsible for sex and age differences in cell death, inflammatory responses, and neural repair throughout the lifespan. The goal of my program is to translate these findings into novel, targeted therapies for use in patients of both sexes, and the R35 funding mechanism will allow me to pursue innovative research by providing stable funding over the next eight years.

PI_NAMEs: MCCULLOUGH, LOUISE D. (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adipose tissue;Affect;Age;age difference;Aging;Area;Behavioral;Biological;Biological Factors;Blood Vessels;boys;Brain;cardiovascular health;Cell Death;Cerebrovascular Disorders;Cerebrovascular system;Clinical;Clinical Trials;disability;Disparity;Economic Burden;Elderly woman;Enrollment;Estrogens;Female;Funding;Funding Mechanisms;Genes;genotypic sex;Goals;Immunologics;improved;Inflammaging;Inflammation;Inflammatory Response;innovation;Ischemia;Knowledge;life span;male;men;microbiome;Microglia;Mus;National Institute of Neurological Disorders and Stroke;neonatal injury;neonate;Nervous System Disorder;neural repair;Neurologist;neurophysiology;Neuroprotective Agents;novel;Outcome;Patients;Persons;Policies;Population;post stroke;post stroke cognitive impairment;post stroke depression;preclinical study;Prevention;programs;Protocols documentation;Public Health;Quality of life;reproductive senescence;Research;response to brain injury;sex;Sex Differences;social factors;Social isolation;Stroke;success;targeted treatment;tool;Translating;translational scientist;United States;United States National Institutes of Health;Vascular Dementia;Vascular Diseases;Woman;Women's trial;Work;X Chromosome

PROJECT_TITLE: Sex Differences in Inflammation Across the Lifespan


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE To enable safe and efficient advancement of genome editing therapeutics to the human clinical setting, it is essential to obtain preclinical data supporting safety and efficiency, but simple cell cultures and animal models have substantial limitations in predicting outcome in human tissues. Human organoids are 'mini-organ'-like structures grown in lab dishes that possess many key features of tissues, including diverse cell types in sophisticated arrangements specific to different organs, and disease phenotypes specific to individuals from whom they are derived. The objective of these studies is to blueprint a new predictive approach for genome editing efficiency and safety in human organoids, which can be used to de-risk strategies for regulatory consideration relevant to a wide variety of genome editing therapies.

PI_NAMEs: FREEDMAN, BENJAMIN SOLOMON (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: 3-Dimensional;Acceleration;Adverse event;American;Animal Model;Animals;APOL1 gene;Architecture;Biological Assay;Biological Models;Body System;Brain;Cell Culture Techniques;Cell Line;cell type;Cells;Clinic;Clinical;clinical development;Clinical Trials;Collaborations;college;commercialization;comparative;Complement;Complex;Data;Data Set;detection assay;Disease;disease phenotype;DNA;DNA Sequence;Dose;drug development;Elements;Ensure;Evaluation;experimental study;gene editing technology;Genes;genome editing;genotoxicity;Heart;Human;human data;Human Genome;human pluripotent stem cell;human tissue;Immune response;immunogenic;improved;In Vitro;in vivo;Individual;Innate Immune Response;interest;Intervention;Investigation;Investigational Drugs;Kidney;Liver;Lung;Macaca mulatta;Measurement;Measures;meetings;Methodology;Microscopy;Modeling;Monitor;Monkeys;Neurons;nonhuman primate;novel;nuclease;Oncogenic;Organ;Organoids;Outcome;outcome prediction;Patients;Phase;Population;pre-clinical;Pre-Clinical Model;Predictive Value;Primates;Protocols documentation;prototype;Reference Standards;Reproducibility;research clinical testing;response;Retina;Ribonucleoproteins;Risk;Rodent;Route;Safety;side effect;single cell sequencing;somatic cell gene editing;Species Specificity;Structure;synergism;System;Technology;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic candidate;therapeutic genome editing;therapeutic target;Tissues;tool;Toxicology;Viral

PROJECT_TITLE: Utility of Human Organoids for Safety and Efficiency Evaluations of Genome Editing Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(70)R]


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Project Narrative: While precise tuning of gene expression levels is critical for most developmental pathways, the mechanisms by which the transcriptional output of dosage-sensitive molecules is established remain poorly understood. Experiments outlined in this proposal aim to combine the genetic tractability of C. elegans and a novel imaging approach to directly determine how transcriptional dynamics are tuned to generate precise phenotypic outcomes. Specifically, these studies will determine the molecular mechanisms by which two transcription factors, BLMP-1 and LIN-42, modulate aspects of transcriptional bursting to determine the expression levels of key miRNAs that dictate temporal cell fate specification during post-embryonic development.

PI_NAMEs: HAMMELL, CHRISTOPHER MARTIN (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Alleles;Animals;ATAC-seq;Binding;Caenorhabditis elegans;cell fate specification;Cell Nucleus;Cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Decision Making;Defect;Development;Developmental Gene;Dimensions;Disease;Dissection;DNA;DNA Binding;DNA Polymerase II;DNA-Binding Proteins;dosage;Embryonic Development;Enhancers;Ensure;Enzymes;experimental study;Frequencies;Funding;Future;Gene Dosage;Gene Expression;Gene Expression Regulation;gene function;gene regulatory network;Genes;Genetic;Genetic Transcription;Genomic approach;genomic locus;Genomics;Homeostasis;imaging approach;imaging platform;In Vitro;in vivo imaging system;Individual;Larva;Lobular Neoplasia;Location;Maintenance;Maps;Measures;Mediating;Microfluidics;MicroRNAs;Molecular;Monitor;mutant;Mutation;novel;Nuclear Hormone Receptors;Nucleic Acid Regulatory Sequences;Nucleosomes;Outcome;Output;Pathway interactions;Pattern;Periodicity;Phenotype;Physiologic pulse;Postembryonic;Process;programs;protein function;Proteins;real time model;recruit;Regulation;Regulator Genes;Reporter;Repression;Research;Resolution;response;RNA;Signal Transduction;Site;System;Technology;Time;Transcript;transcription factor;Transcriptional Activation;Transcriptional Regulation

PROJECT_TITLE: Oscillatory gene expression and the maintenance of temporal patterning

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The studies proposed herein are designed to investigate how pre-surgical/neoadjuvant immunotherapy may alter the systemic immune response and modify the tumor immune microenvironment in recurrent glioblastoma patients. We will take advantage of our unique access to biological samples, clinical data, and imaging data from an ongoing investigator-initiated clinical trial with Bristol Myers Squibb testing PD-1 (nivolumab) with or without CTLA-4 (ipilimumab) antibody blockade in the neoadjuvant setting and following a planned surgical resection. This project could potentially be transformative, as a better understanding of how neoadjuvant immunotherapy alters immune responses within the tumor could teach us important lessons about the critical requirements for productive anti-tumor responses in glioblastoma and how adaptive resistance occurs in this disease.

PI_NAMEs: PRINS, ROBERT M (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adverse event;Aftercare;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Antitumor Response;Biological;Blood;Blood Cells;Brain;Brain Neoplasms;CD8B1 gene;Cell Cycle;Cell Cycle Regulation;Cells;Cephalic;chemotherapy;Clinical;Clinical Data;Clinical Trials;Clone Cells;cohort;Combined Modality Therapy;CTLA4 blockade;CTLA4 gene;Data;density;design;Diagnosis;Disease;Down-Regulation;early detection biomarkers;Educational process of instructing;Excision;Gene Expression;Genetic Transcription;Glioblastoma;hazard;Human;Image;Immune;immune checkpoint blockade;Immune response;Immunofluorescence Immunologic;immunogenicity;Immunologic Monitoring;Immunologics;ImmunoPET;Immunotherapy;Infiltration;Interferon Type II;ipilimumab;Long-Term Survivors;lymph nodes;lymphoid neoplasm;lymphoid organ;Magnetic Resonance Imaging;Malignant Neoplasms;Monitor;Monoclonal Antibodies;Neoadjuvant Therapy;neoplastic cell;Nivolumab;non-invasive imaging;novel;Operative Surgical Procedures;patient population;Patients;PD-1 blockade;peripheral blood;phase III trial;Positron-Emission Tomography;pre-clinical;primary endpoint;Productivity;programmed cell death protein 1;Progression-Free Survivals;Publishing;Radiation therapy;randomized trial;randomized, clinical trials;Recurrence;refractory cancer;Research Personnel;Resistance;Resistance development;response;response biomarker;Sampling;Scanning;secondary endpoint;T cell infiltration;T cell regulation;T-Lymphocyte;Testing;Toxic effect;transcriptome sequencing;treatment group;tumor;Tumor Cell Invasion;Tumor Expansion;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Up-Regulation;uptake;Work

PROJECT_TITLE: Neoadjuvant checkpoint blockade for recurrent glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative We are proposing to develop the next generation of small molecule inhibitors of the menin-MLL1 interaction and assess their activity in advanced models of leukemia with upregulated HOX genes. Ultimately, such compounds are expected to become highly specific drugs for patients with aggressive forms of acute leukemia, which poorly respond to current therapies.

PI_NAMEs: GREMBECKA, JOLANTA  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adult;Affect;analog;Animals;Binding;Binding Sites;Biological;Child;Chimeric Proteins;Chromosomal translocation;Clinical;clinical candidate;Clinical Data;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Collaborations;Complex;Crystallography;Data;design;Development;Disease remission;Down-Regulation;Drug Kinetics;Drug Targeting;effectiveness evaluation;FDA approved;Foundations;Future;Genes;Goals;Growth;Homeobox Genes;HOXA9 gene;improved;in vivo;inhibitor;interdisciplinary approach;Lead;leukemia;leukemia treatment;Leukemic Cell;leukemogenesis;MEIS1 gene;Menin;Metabolic;Mixed-Lineage Leukemia;Modeling;Molecular Conformation;mouse model;Mutate;Mutation;N-terminal;nanomolar;new therapeutic target;next generation;novel;novel therapeutics;Nuclear Pore Complex Proteins;nucleophosmin;Oncogenic;Oncology;Outcome;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Play;Prognosis;Proliferating;Property;protein protein interaction;Proteins;recruit;Remission Induction;Reporting;Resistance development;Role;Sampling;scaffold;side effect;small molecule;small molecule inhibitor;Solubility;Structure;Survival Rate;therapeutic target;Toxic effect;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: Targeting Menin in Acute Leukemia with Upregulated HOX Genes

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Activity;Prevention;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness;Telehealth

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This R01 application involves an intervention approach that combines telehealth physical exercise training with telehealth cognitive training to increase neurotrophins and enhance the impact of cognitive training on cognitive deficits in schizophrenia. Both cognitive training and exercise address the NIMH strategic research priorities for creating innovative interventions that can be “disseminated broadly” and “readily taught to the existing workforce with minimal cost”. The future portability of this combined intervention outside of academic research programs will be evaluated by providing the interventions via videoconferencing. Cognitive deficits in persons with schizophrenia present an enormous challenge to successful return to functioning in the community, so this research has potential to be of major public health significance for community functioning of individuals with schizophrenia.

PI_NAMEs: NUECHTERLEIN, KEITH H (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Advocate;Aerobic Exercise;Applications Grants;Brain-Derived Neurotrophic Factor;Chronic disability;Clinic;Clinical Trials;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive training;Combined Modality Therapy;Communities;computerized;confirmatory clinical trial;cost;Data;design;Disease;Educational Intervention;Educational process of instructing;efficacy validation;Exercise;exercise program;exercise training;first episode schizophrenia;fitbit;fitness;functional outcomes;Future;improved;Individual;innovation;Intervention;intrinsic motivation;Investigational Therapies;Measures;Methods;Motivation;National Institute of Mental Health;Neuronal Plasticity;neurotrophic factor;Nonpharmacologic Therapy;novel;Online Systems;Outcome;Outpatients;Persons;Physical Exercise;portability;primary outcome;programs;psychotic;Public Health;Research;Research Priority;Schizophrenia;Schools;severe mental illness;Signal Transduction;Synaptic plasticity;telehealth;Testing;Text Messaging;Time;Training;Training Programs;Treatment Efficacy;United States National Institutes of Health;videoconference;Videoconferencing;Work;Wrist

PROJECT_TITLE: Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode


ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Narrative  Bacteria contain unique wobble uridine modifications and writer enzymes, and these epitranscriptomic systems have been linked to stress responses. In this application we will use chemical biology approaches to synthesize and characterize wobble uridine modifications and define the roles of these RNA modifications and their writers in gene regulation. We will also exploit the bacterial wobble uridine writer MnmH (SelU) by developing clickable ligands that will be used to identify RNA modifications in yeast and human cancer cells. Ultimately our studies will develop a unified understanding of the 12 different wobble uridines in bacterial tRNA and provide new tools for epitranscriptomic research.

PI_NAMEs: BEGLEY, THOMAS J;SHENG, JIA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TITLE: Chemical Modifications to Wobble Uridines in tRNA Regulate Responses to Stress

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: ARIMA GENOMICS, INC.

PHR: Developing a kit-based research use only (RUO) translocation assay for deployment as a lab developed test (LDT) toward changing outcomes for patients with driver-negative tumors (RFA sub-section: Technology platform for Cancer Diagnostics) PROJECT NARRATIVE The advent of personalized medicine, whereby a patient is treated based on the genetic aberrations driving their tumor, has transformed cancer by matching patients with targeted therapies tailored to their tumors. Despite this transformation, approximately 50% of advanced stage tumors have no genetic driver that can be detected using existing technologies, precluding access to targeted therapies and worsening their prognosis. Arima Genomics aims to tackle this critical unmet by developing and commercializing the T-Seq kit, which detects clinically actionable genetic drivers in otherwise driver-negative tumors, enabling patients to benefit from the promise of precision medicine and targeted therapies. Based on foundational product development and clinical study data, Arima is now proposing the necessary next steps to become a technology provider to CLIA labs, where CLIA labs will validate the deploy T-Seq kits as LDTs to guide clinical care of cancer patients.

PI_NAMEs: SELVARAJ, SIDDARTH  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Advanced Malignant Neoplasm;Automobile Driving;Award;Awareness;Biological Assay;Biopsy;bridge program;cancer care;Cancer Diagnostics;Cancer Patient;Cell Nucleus;Cessation of life;Classification;Clinical;clinical care;Clinical Data;Clinical Research;clinically actionable;commercialization;Creativeness;Data;Detection;Diagnosis;DNA;Ecosystem;Event;Failure;Future;Gene Fusion;Genetic;genetic profiling;Genome;Genomics;girls;Goals;Guidelines;Hand;Healthcare Systems;improved;individualized medicine;Informatics;insight;Label;Laboratories;Large Intestine Carcinoma;lens;Letters;Light;Lymphoma;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;manufacture;Maps;Marketing;Measurement;Measures;meetings;Methods;Mission;Mutation;Neighborhoods;Non-Small-Cell Lung Carcinoma;Oncologist;Outcome;Pathologist;Pathology;Patient Care;Patient-Focused Outcomes;Patients;pembrolizumab;Performance;personalized medicine;Phase;precision medicine;preservation;Press Releases;product development;Prognosis;programmed cell death ligand 1;programs;prospective;Provider;Publications;Recovery;Reporting;Reproducibility;Research;RNA;Sampling;Series;Severities;Shapes;Specificity;success;targeted treatment;Technology;technology platform;Teenagers;Testing;therapy resistant;tumor;Tumor stage;Uterine Corpus Sarcoma;Validation


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Studying the functional role of various classes of RNAs can lead to better handling of the downstream pathologic events to control the ischemic brain damage. The present project is an effort to study the interaction of noncoding RNAs, epigenetics and epitranscriptomics in modulating secondary brain damage after stroke. The long-term goal is to identify novel targets amenable for therapeutic development to promote recovery after stroke

PI_NAMEs: VEMUGANTI, RAGHU  (contact)

PROJECT_TERMS: Adenosine;Apoptotic;Binding;Brain;Brain Injuries;Cerebral Ischemia;Chemicals;circular RNA;Code;Collaborations;demethylation;design;DNA;Epigenetic Process;epitranscriptomics;Event;functional outcomes;Funding;Future;Genes;Genetic Transcription;glycation;Goals;Grant;Inflammation;Inflammatory;Ischemia;Ischemic Brain Injury;Mediating;Messenger RNA;Methylation;MicroRNAs;Modification;Molecular;neural;neuroprotection;new therapeutic target;novel;novel therapeutics;Pathologic;Positioning Attribute;post stroke;Post-Transcriptional Regulation;receptor;Recovery;Recovery of Function;Research;RNA;RNA methylation;RNA-Binding Proteins;Role;sialic acid binding Ig-like lectin;Stroke;synuclein;therapeutic development;tool;Untranslated RNA

PROJECT_TITLE: Role of RNAs in post-stroke brain damage


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARATIVE The human genome is epigenetically regulated through protein-DNA interactions, histone modifications, and DNA methylation. However, current methods for measuring these regulatory elements, cannot map the epigenetic landscape in the ~8% of the genome that contains highly-repetitive sequences, nor do they have the sensitivity to measure epigenetic variation between single cells. The goal of this research program is to develop new tools for mapping protein-DNA interactions in long single molecules and in single cells, allowing complete profiling of epigenetic regulation in the human genome from telomere to telomere and with enough sensitivity to shed light on cell-to-cell epigenetic variability in developing or diseased tissues.

PI_NAMEs: STREETS, AARON  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Adenine;Antibodies;Atlases;base;Base Pairing;Binding;Binding Proteins;Bioinformatics;Biological Models;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Centromere;Chimeric Proteins;ChIP-seq;Chromosome Mapping;Chromosome Segregation;Cleavage Under Targets and Release Using Nuclease;Complex;Dedications;Detection;Development;Developmental Process;Digestion;Disease;DNA;DNA Binding;DNA Methylation;DNA Sequence;DNA sequencing;DNA-Protein Interaction;Encyclopedia of DNA Elements;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenetic variation;epigenomics;Evolution;Exclusion;Genetic;Genetic Transcription;Genome;genome-wide;Genomic DNA;genomic locus;Genomics;Goals;high standard;High-Throughput Nucleotide Sequencing;histone modification;Human;Human Genome;Individual;interest;Investigation;Libraries;Ligation;Maps;Measurement;Measures;Methods;Methylation;Methyltransferase;Microfluidics;Modification;nanopore;Noise;novel;Nuclear;Nucleic Acid Regulatory Sequences;Pathogenesis;Phenotype;Play;Population;Positioning Attribute;Preparation;prevent;Process;programs;Proteins;Protocols documentation;Regulation;Regulatory Element;Repetitive Sequence;Research;Resolution;Ribosomal DNA;Ribosomal RNA;Role;sequencing platform;Signal Transduction;single cell analysis;single cell sequencing;single molecule;Site;Site-Directed Mutagenesis;Stretching;Techniques;Technology;telomere;Tissues;tool;transcription factor;Transcriptional Regulation;Translational Regulation;Variant

PROJECT_TITLE: Methods for Mapping Genetic Regulatory Elements in Single Cells and Single Molecules

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: REHOVOT

ORG_COUNTRY: ISRAEL

ORG_FIPS: IS

ORG_NAME: WEIZMANN INSTITUTE OF SCIENCE

PHR: Project Narrative This research aims to examine whether sub-optimal DNA repair activity directed to oxidative DNA damage is involved in lung cancer etiology, and can aid prediction of the development of lung cancer. This is expected to lead to clinically-validated DNA repair-based biomarkers for risk assessment of lung cancer, which will improve risk estimates, and provide better selection criteria for early detection of lung cancer by methods such as low-dose CT. It may also be used for predicting lung cancer risk of individuals with indeterminate pulmonary nodules, aiding clinician’s in the decisiosn making on further diagnostic steps.

PI_NAMEs: LIVNEH, ZVI  (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Adenocarcinoma;Age;Aging;Appearance;Base Excision Repairs;Biological Assay;Biological Markers;Biological Process;biomarker validation;Blood;Blood specimen;Blood Tests;Cancer Etiology;cancer risk;cancer type;carcinogenesis;carcinogenicity;case control;Case/Control Studies;Clinical;Cryopreservation;Data;design;Diagnosis;Diagnostic;Disease;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;Early Diagnosis;Effectiveness;enzyme activity;Enzymes;epidemiology study;Etiology;Freezing;Goals;Histology;improved;Individual;Inherited;Knowledge;low dose computed tomography;lung cancer screening;lung development;Lung nodule;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Metabolism;Methods;Modeling;Mutation;Nested Case-Control Study;never smoker;Non-Small-Cell Lung Carcinoma;Occupational;OGG1 gene;Outcome Study;oxidative DNA damage;Pathway interactions;Play;prevent;Prevention;Prospective cohort;Prospective, cohort study;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Radiation;repair enzyme;repaired;Reporting;Reproducibility;Research;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;Role;Sampling;screening;Selection Criteria;Smoker;Smoking;Smoking Status;Squamous cell carcinoma;T-Lymphocyte;Testing;Time;Tobacco smoke;tumor;Whole Blood

PROJECT_TITLE: Analysis of the predictability of lung cancer using DNA Repair functional assays and cryopreserved blood samples of the PLCO prospective cohort


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: GREENSBORO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

ORG_STATE: NC

PHR: PROJECT NARRATIVE Black emerging adults (ages 18-28 years) have the highest risks of insufficient sleep and obesity, but little is known about how and why these disparities exist. Our project will examine the impacts of insufficient sleep, race- related stress and living in more disadvantaged home and neighborhood environments on weight-related mechanisms and obesity markers in Black emerging adults over a 12-month period. By focusing on emerging adulthood – when many individuals establish and solidify lifelong sleep and health behaviors – this project will take an essential first step toward identifying lifestyle intervention targets rooted within Black cultural strengths and values to mitigate disparities in sleep and obesity.

PI_NAMEs: MCNEIL, JESSICA NICOLE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: actigraphy;Adolescence;Adult;Age;Biological;biological systems;Black race;Body Weight;community advisory board;coping;Cross-Sectional Studies;Data Collection;Desire for food;diaries;Disadvantaged;Discrimination;Disparity;disparity reduction;Economics;emerging adult;emerging adulthood;energy balance;Energy Intake;Energy Metabolism;Environment;experience;Fatty acid glycerol esters;Feeling;follow-up;Food;Health behavior;high risk;Home;Hydration status;Hydrocortisone;Individual;insight;interest;Intervention;Knowledge;Laboratories;lifestyle intervention;Link;Measures;Mediating;Methods;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Neighborhoods;Obesity;obesity risk;Participant;Pathway interactions;Patient Recruitments;Patient Self-Report;peer;Polysomnography;poor sleep;Population;Prevalence;prospective;Prospective Studies;Public Health;Race;racial identity;racial population;racism;Research Activity;Research Personnel;Research Support;response;Rewards;Risk;Role;Sample Size;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Deprivation;sleep onset;sleep quality;Slow-Wave Sleep;social;Socialization;Societies;Stress;Surveys;Technology;vigilance;waist circumference;Weight;Weight Gain;Work

PROJECT_TITLE: Linking insufficient sleep with body weight in Black emerging adults.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative The goal of this project is to investigate how cholinergic and noradrenergic circuits contribute to perceptual decision-making. Decision-making, is critical in environments where performance depends on detecting and responding appropriately to near threshold stimuli. In this project, we will investigate how cholinergic and noradrenergic neuromodulators contribute to immediate and long-term behavioral performance using laminar electrophysiology and fiber photometry with GRAB-Ach and GRAB-NE neurotransmitter reporters.

PI_NAMEs: DRANOVSKY, ALEX ;FERRERA, VINCENT P (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acetylcholine;Affect;area striata;Arousal;Attention;awake;Behavior;behavior measurement;Behavioral;Behavioral Paradigm;Cerebral cortex;cholinergic;Code;Cognitive;Decision Making;Detection;Electrodes;Electrophysiology (science);Environment;experimental study;Eyelid structure;Failure;Fiber;Future;Goals;information processing;Injections;large scale data;Linear Models;Measures;Modeling;Monitor;Motivation;neural;Neuromodulator;Neurons;neuroregulation;Neurotransmitters;Noise;nonhuman primate;noradrenergic;Norepinephrine;novel;Pattern;Perception;Performance;Pharmaceutical Preparations;Photometry;Positioning Attribute;Psychophysics;Pupil;Reaction Time;Reporter;Resolution;response;sample fixation;Sampling;Sensory;sensory cortex;Short-Term Memory;Signal Transduction;Site;Statistical Models;Stimulus;System;temporal measurement;Testing;theories;Time;tool;Training;Visual;Visual Cortex;Work

PROJECT_TITLE: Neuromodulation in visual cortex

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Cellular senescence contributes to age-related tissue and organ dysfunction and various age-related diseases. Senescent cells arise in response to DNA damage, including aneuploidy (i.e. the gain or loss of entire chromosomes) and accumulate with age. Preventing their accumulation delays age-related diseases. This project explores how aneuploid cells may be recognized and eliminated by cell competition using mice as experimental animals. Understanding of this process may help recognize how senescent cells accumulate during aging in tissues and could help develop means to delay the emergence of aging phenotypes.

PI_NAMEs: BAKER, NICHOLAS E;HUFFMAN, DEREK MAJOR (contact);MONTAGNA, CRISTINA

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age-related disease;aged;Aging;aging related disease;Alleles;Amino Acid Substitution;Aneuploid Cells;Aneuploidy;Animal Experiments;Behavioral;beta-Galactosidase;Biological Assay;Brain;Bypass;CDKN2A gene;Cell Aging;Cell Cycle Arrest;cell injury;Cell Nucleus;Cell Survival;Cells;Chromosome Mapping;chromosome number abnormality;Chromosome Segregation;Chromosomes;Custom;detection method;Deterioration;Development;Diploidy;Disease;DNA;DNA Damage;Drosophila genus;Drosophila melanogaster;Embryo;Failure;Fluorescent in Situ Hybridization;Frequencies;Functional disorder;Gamma-H2AX;Gene Dosage;Gene Proteins;Genes;Genetic Screening;Genome;Genome Stability;genome-wide;health assessment;healthspan;healthy aging;Heart;HMGB Family Gene;Homeodomain Proteins;improved;Incidence;Inflammatory;Interphase;late life;Liver;LMNB1 gene;Longitudinal Studies;Mammals;Measures;Metabolic;Monitor;mosaic;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel;Nuclear;Organ;p53-binding protein 1;Pathway interactions;Phenotype;Phosphotransferases;Play;Ploidies;Postpartum Period;prevent;Process;Property;Rejuvenation;Research;response;Ribosomal Proteins;Risk Factors;Role;Route;senescence;senescent cell;sensor;Siblings;Signal Transduction;Testing;Tissues;Tomatoes

PROJECT_TITLE: Cell competition, aneuploidy, and aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative This is a collaborative project bringing together several leading muscle research labs with complementary expertise in structural biophysics, physiology, animal models, and medicinal chemistry. Our goal is to develop and apply technology for drug discovery, targeting calcium transport regulation in skeletal muscle, with direct relevance to skeletal myopathies, as well as numerous other disorders for which improved therapies are urgently needed.

PI_NAMEs: LOWE, DAWN A;REBBECK, ROBYN T;THOMAS, DAVID D (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Animal Model;Animal Testing;Animals;ATP phosphohydrolase;Back;Binding;Biochemical;Biological Assay;Biophysics;Biosensor;Ca(2+)-Transporting ATPase;Calcium;Calcium Channel;Calmodulin;Cardiac;Cells;Clinical;Collaborations;combat;Cornea;Cytoplasm;design;Detection;Disease;disease model;drug candidate;drug discovery;drug efficacy;Drug Industry;drug testing;Engineering;Ensure;enzyme structure;Enzyme Uncoupling;Enzymes;Fiber;FKBP1B gene;Fluorescence;Fluorescence Resonance Energy Transfer;Future;Generations;genetic regulatory protein;Goals;Healthcare;high throughput screening;Homeostasis;Impairment;improved;In Vitro;in vitro Assay;in vivo;innovation;Label;Libraries;Link;Membrane;Modification;mouse model;Mus;Muscle;Muscle function;Muscle Proteins;Mutation;Myocardium;Myopathy;Nature;novel strategies;novel therapeutics;oxidation;Pathology;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Post-Translational Protein Processing;pre-clinical;protein structure;Proteins;Regulation;Relaxation;Research;RyR1;sarcolipin;Sarcoplasmic Reticulum;screening;SERCA2a;Site;skeletal;Skeletal Muscle;small molecule;small molecule libraries;small molecule therapeutics;Specificity;Speed;structural biology;Structure;System;Tacrolimus Binding Protein 1A;Technology;Testing;Therapeutic Agents;therapeutic development;therapeutic target;therapeutically effective;translational impact;uptake

PROJECT_TITLE: Skeletal muscle protein structural dynamics and function drive applications to drug discovery

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_NAME: NEW YORK GENOME CENTER

PHR: PROJECT NARRATIVE - NEW YORK GENOME CHARACTERIZATION CENTER The New York Genome Characterization Center (NYGCC) aims to contribute to the creation of a comprehensive catalog of somatic variation in tissues from healthy individuals by applying three state-of-the-art core sequencing assays: deep, duplex short read whole genome sequencing, RNA sequencing, and deep long read genome sequencing. In addition, we will perform two other assays: single cell amplification-free whole genome sequencing and targeted single cell somatic variant genotyping of transcriptomes together with single cell gene expression. We believe the three core assays will provide an unprecedented and comprehensive view of somatic mutations across a variety of healthy tissues, while the two additional assays will allow us to explore the cellular contexts and effects of the somatic variants in these tissues.

PI_NAMEs: APARICIO, SAMUEL ;GERMER, SOREN  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: aging process;analysis pipeline;Automation;Automobile Driving;Benchmarking;Biological Assay;Blood;Cardiovascular Diseases;Catalogs;Cell Lineage;Cell surface;cell type;Cells;Clonal Expansion;cohort;Collaborations;Communities;Data;Data Analyses;data exchange;Data Files;data format;data quality;Data Reporting;Data Set;Detection;detection sensitivity;Development;Disease;disease phenotype;DNA Sequence;DNA Sequencing Facility;Elements;Ensure;Ethnic Origin;Evolution;experience;falls;file format;fitness;Gene Expression;Genes;Genome;genome sequencing;genome wide association study;Genotype;Germ-Line Mutation;Goals;Grant;Health;Human;Human Resources;human tissue;Immune System Diseases;improved;Individual;innovation;insertion/deletion mutation;Laboratories;laboratory development;laboratory experiment;Large-Scale Sequencing;Libraries;life span;Loss of Heterozygosity;Mediating;meetings;Metadata;Methods;Monitor;Mosaicism;mRNA sequencing;Mutation;nanopore;Neurodegenerative Disorders;Neurodevelopmental Disorder;new technology;New York;organizational structure;Pathogenesis;Patients;Pattern;Persons;Play;Population;Preparation;Procedures;Process;process improvement;Production;programs;Protocols documentation;Quality Control;racial diversity;Recurrence;RNA Splicing;Role;Running;Saliva;Sampling;Sensitivity and Specificity;Somatic Cell;Somatic Mutation;Staff Development;System;task analysis;Technology;technology development;Tissue Procurements;Tissues;Transcript;transcriptome;transcriptome sequencing;Tumor Biology;Variant;variant detection;whole genome;Work

PROJECT_TITLE: New York Genome Characterization Center: Somatic Mosaicism across Human Tissues


ORG_CITY: SYKESVILLE

ORG_NAME: ZETEO TECH, INC.

PHR: Project Narrative Lower respiratory tract infection (LRTI) affects patients more often in ICUs, especially patients with mechanical ventilators. We propose to determine whether truncated proteoforms in human exhaled air can be used as a noninvasive method for LRTI diagnosis and early prediction of LRTI in mechanically ventilated patients. Our work would largely assist decision-making for clinicians regarding antibiotic treatment and dramatically improve patients' clinical outcomes by limiting antibiotic requirements and minimizing harmful exposure to unnecessary antibiotic treatment.

PI_NAMEs: CHEN, DAPENG  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Affect;Air;air sampling;Algorithms;Antibiotic Therapy;Antibiotics;Biological Assay;Biological Markers;Breath Tests;Cause of Death;Clinical;clinical diagnosis;Collaborations;Collection;Communicable Diseases;Control Groups;Critical Care;Death Rate;Decision Making;design;Deterioration;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic biomarker;Diagnostic Procedure;diagnostic technologies;Early Diagnosis;Early Intervention;Economic Burden;Exhalation;expectation;experience;Exposure to;Face;Functional disorder;Future;Healthcare Systems;high risk;Hospitals;Human;improved;Individual;Infection;innovation;Intensive Care Units;Intubation;invention;Lipids;Literature;Lower Respiratory Tract Infection;Lower respiratory tract structure;Lung infections;Mass Spectrum Analysis;Mechanical ventilation;Mechanical Ventilators;Medical;Methodology;Methods;molecular diagnostics;multiplex assay;noninvasive diagnosis;novel;novel diagnostics;Outcome;pathogen;Patients;Peptide Hydrolases;Performance;Phase;Pilot Projects;Polymerase Chain Reaction;prevent;Process;product development;Proteins;Proteolysis;Proteomics;Publishing;Risk;Sampling;Sepsis;Septic Shock;Surgical Intensive Care;Symptoms;System;Technology;Testing;Time;Training;Treatment Cost;validation studies;verification and validation;Work

PROJECT_TITLE: Noninvasive Diagnostic Markers of Lower Respiratory Tract Infection in Mechanically Ventilated Patients


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project narrative Our investigation of the crosstalk between ferroptosis and polyunsaturated fatty acid metabolism will lead to a better understanding of the role of polyunsaturated fatty acid metabolites in programmed cell death that will have huge implications on human physiology and may identify novel treatments for many diseases. Specifically, we will combine synthetic metabolites and mimics as powerful chemical probes, state-of-the-art analytical tools, genetic tools, and a novel model organism to delineate how polyunsaturated fatty acid metabolites regulate ferroptosis. Our preliminary data and data from others suggest that specific polyunsaturated fatty acids trigger ferroptosis and inhibition of polyunsaturated fatty acid metabolism rescues ferroptosis triggered by specific polyunsaturated fatty acids illustrating that particular polyunsaturated fatty acids or their metabolites could have a major role in ferroptosis.

PI_NAMEs: LEE, KIN SING STEPHEN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;analytical tool;Apoptosis;Biological;Biological Models;Cell Aging;Cell Respiration;cell type;Cells;Chemicals;Cytochrome P450;Data;design;Disease;drug candidate;Embryonic Development;fatty acid metabolism;Foundations;Genetic;Germ Lines;Goals;Health;high throughput screening;Homeostasis;Human;in vivo;inhibitor;Investigation;Iron;lipid mediator;Lipid Peroxidation;Mediator;Membrane Lipids;Metabolic;Methods;model organism;Modeling;Neurons;novel;Outcome;Physiology;Polyunsaturated Fatty Acids;programs;Proteins;Regulation;Regulatory Pathway;Research;Role;Signaling Molecule;Signaling Protein;Testing;Tissues;tool;Transgenic Organisms;Translational Research

PROJECT_TITLE: Ferroptosis and Polyunsaturated Fatty Acid Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Primary Health Care;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Short sleep duration and sleep-wake irregularity are significantly associated with adolescent depression and are considered key mechanisms of disease; thus, these sleep parameters are critical intervention targets for depressed youth. Efficacious behavioral strategies for disturbed adolescent sleep lead to improved sleep and depression, but little work has aimed to translate evidence-based sleep and rhythm strategies from the research environment for use in pediatric primary care. In this R34 we will involve stakeholders in translating a sleep promotion program (SPP) for implementation in pediatric primary care and in the development of feasible and acceptable provider training, and in evaluating the effectiveness and implementation of the SPP program and provider training via pilot randomized control trial.

PI_NAMEs: LEVENSON, JESSICA C (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adolescent;Adolescent Medicine;Adoption;Behavioral;behavioral health;care systems;Caring;Cellular Phone;Child;child depression;Childhood;circadian;Clinic;Communities;Consolidated Framework for Implementation Research;cost;Data;Depressed mood;depressive symptoms;Development;diaries;Disease;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness testing;emotion dysregulation;Environment;evidence base;Evidence based practice;feasibility testing;Feedback;follow-up;Goals;Health Personnel;hybrid type 2 trial;Impairment;implementation barriers;implementation determinants;implementation evaluation;implementation research;improved;improvement on sleep;Individual;Intervention;Interview;Investigational Therapies;Knowledge;Lead;Left;Link;Manuals;Measures;Mediation;Mental Depression;Mental disorders;Mental Health;Moods;National Institute of Mental Health;Nurses;Outcome;Outcome Assessment;Participant;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Pediatrics;Persons;poor sleep;post intervention;practice setting;Primary Care;primary care practice;primary care provider;primary outcome;Procedures;Program Effectiveness;programs;Provider;psychoeducation;Randomized, Controlled Trials;Recommendation;Reporting;Research;Resources;response;Sampling;Schools;screening;Sleep;sleep behavior;Sleep disturbances;Social Workers;Specialist;Strategic Planning;suicidal adolescent;suicidal risk;Suicide attempt;Surgeon;Surveys;Technology;Testing;Time;Training;Translating;Translations;Update;Work;Youth

PROJECT_TITLE: A Sleep Promotion Program for Depressed Adolescents in Pediatric Primary Care

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE The ISEE annual conference plays a vital role in facilitating dialogue among leading environmental epidemiologists. The conference is the most prominent and comprehensive international gathering of environmental epidemiologists and related environmental health professionals from academia, government, and public health organizations. It provides a forum for discussion, critical review, collaboration, and education concerning environmental agents with the ultimate goal of ameliorating their public health impacts.

PI_NAMEs: BRAUN, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Academia;Address;Africa;Air Pollution;Area;Asia;Attention;built environment;Caribbean region;Chemicals;Chile;climate change;climate-related health;Collaborations;Communication;Community Participation;Country;Developing Countries;Development;Disparity population;Ecosystem;Education;Ensure;environmental agent;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;environmental intervention;Epidemiologist;Epidemiology;epidemiology study;Equity;Europe;experience;Face;Food production;Fostering;Funding;global environment;Goals;Government;Health;health equity;health organization;Health Professional;Human;Industrialization;Institution;International;Justice;Latin America;meetings;Mentors;Metals;Methodology;Methods;Multinational Perspectives;North America;Outcome;Participant;Planets;Play;Population;Public Health;Research;Research Methodology;Research Personnel;Resources;Role;Scholarship;Scientific Societies;Scientist;social disparities;Societies;South America;Students;symposium;Taiwan;Training;Translating;Travel;Underrepresented Minority;Water Pollution;Work

PROJECT_TITLE: Annual Retreat of the International Society for Environmental Epidemiology


NIH_SPENDING_CATS: Genetics;Lymphatic Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Endothelial cells in skin are emerging through mouse genetics studies as potential signaling centers that instruct epithelial cells during tissue maintenance or homeostasis. Whereas endothelial cells in lymphatic vessels have received some recent attention, the role of blood vessels and the molecular signals involved in the communication with epithelial stem cells are unclear and will be addressed here.

PI_NAMEs: TUMBAR, TUDORITA  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Address;Adult;Affect;Arteries;Attention;Behavior;Blood;Blood capillaries;Blood Vessels;BMP4;Cell Lineage;Cells;Cessation of life;Communication;Data;Defect;Disease;Endothelial Cells;Endothelium;Epithelial Cells;epithelial stem cell;Epithelium;Exercise;experimental study;Future;Gene Expression;Gene Expression Profile;Gene Targeting;Genetic;genetic approach;Genetic study;Genomic approach;Growth;Hair;Hair follicle structure;Hematopoietic;Hereditary hemorrhagic telangiectasia;Homeostasis;Human;human disease;intercellular communication;Laboratories;Lymphatic;lymphatic vessel;Maintenance;Maps;Molecular;Morphology;mouse genetics;mouse model;Mus;Mutation;neural;notch protein;novel;Nutrient;Physiological;Play;Process;Proliferating;Regenerative research;regenerative tissue;Regulation;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;skin regeneration;stem cell niche;stem cells;Testing;TGF Beta Signaling Pathway;Time;tissue regeneration;tissue stem cells;Tissues;Transforming Growth Factor beta Receptors;Veins;Work

PROJECT_TITLE: Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skin


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Robot-assisted medical examinations have the potential to improve health outcomes, reduce costs of  care, and reduce infection risks for medical personnel and patients. This project advances the  state-of-the-art in robot-assisted eye examinations to achieve safe, comprehensive, and reliable no-touch  imaging of eye structures.

PI_NAMEs: HAUSER, KRIS  (contact);KUO, ANTHONY NANLIN

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;Address;Age related macular degeneration;aging in place;Algorithms;Anterior;Appearance;Applied Research;Automation;Basic Science;biomedical imaging;care costs;care seeking;Caring;checkup examination;Chronic;Clinical;Clinical Research;Collaborations;Communication;Cornea;COVID-19 pandemic;Data Collection;data quality;Decision Making;Dedications;design;Development;Diagnosis;Disease Surveillance;disease transmission;efficacy evaluation;Epidemic;Equipment;ethnic disparity;Evaluation;Eye;eye center;Eye diseases;Eye Movements;Eyeglasses;falls;Forehead;gender difference;Glaucoma;Head;Head Movements;Health;health assessment;Health Personnel;Healthcare;Human;Human Resources;human subject;Image;Image Analysis;image processing;Improve Access;improved;infection risk;instrument;instrumentation;lens;Maintenance;Manuals;Measurement;Mechanics;Medical;medical examination;men;Modality;Monitor;Motion;Motivation;Movement;novel;older adult;operation;ophthalmic examination;Optical Coherence Tomography;Outcome;Patients;Perception;Phase;Physicians;Play;Positioning Attribute;pressure;Preventive care;Preventive medical care;Procedures;Provider;racial disparity;remote health care;Research;resilience;Retina;retinal imaging;Risk;Robot;robot assistance;robot control;robotic system;Robotics;Role;routine care;rural healthcare;Safety;safety study;Scanning;Schedule;sensor;standard of care;Structure;System;Systems Integration;Tail;three-dimensional visualization;Time;Touch sensation;Training;transmission process;Triage;Work

PROJECT_TITLE: NRI: Toward Safe and Reliable Robotic Eye Examinations


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative: Identification and analysis of the non-coding regions not hosting any functional element that are important for cell proliferation provide a new angle to uncover disease associated genetic variations.

PI_NAMEs: WANG, WEI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Affect;ATAC-seq;Binding;Binding Proteins;Biological Assay;Biological Process;Cell Death;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Characteristics;Chromatin;Chromatin Structure;comparative;Computer Models;CRISPR library;CRISPR screen;Data;deletion library;Disease;Distal;Elements;Enhancers;Epigenetic Process;feature selection;Functional disorder;Genes;Genetic Variation;Genome;genome editing;Global Change;Goals;Hi-C;histone modification;Human Genome;improved;Junk DNA;K-562;Lead;Leukemic Cell;Modeling;Modification;Mutate;Mutation;neural network;Neural Network Simulation;Pathway interactions;Performance;Phenotype;Play;Proliferating;Regulatory Element;Role;screening;single cell ATAC-seq;single-cell RNA sequencing;Somatic Mutation;Technology;therapeutic genome editing;therapeutic target;Therapeutic Uses;Training;Transcriptional Regulation;transcriptomics;Untranslated RNA;Validation;Work

PROJECT_TITLE: Identification and analysis of non-coding loci critical for cell viability and chromatin organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE: The study advances National Institute of Child Health and Human Development (NICHD) dissemination and implementation research priorities of community-based participatory studies to engage communities in prevention of violence and injury, improve quality of life and functional status after violence, and foster resilience. Findings will advance the science for large-scale implementation of technology-based safety interventions in settings of greatest need.

PI_NAMEs: DECKER, MICHELE R. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Adoption;Advocate;Affect;Area;arm;Attitude;Cellular Phone;Characteristics;Code;college;Communities;community engagement;Community Health;community organizations;Conflict (Psychology);Consolidated Framework for Implementation Research;Dangerousness;Data;Decision Aid;Disclosure;Dissemination and Implementation;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation hybrid;efficacy evaluation;experience;Faith;Female;follow-up;Fostering;Frequencies;functional status;Government;Health;Homicide;implementation determinants;implementation strategy;improved;Individual;Informal Sectors;informal support;Injury;innovation;Institution;International;Internet;Intervention;intervention effect;Interview;intimate partner violence;Justice;Kenya;Knowledge;Leadership;life span;Link;low and middle-income countries;Maintenance;meetings;Mental Health;Methods;mHealth;mobile computing;mortality;National Institute of Child Health and Human Development;Nature;Nongovernmental Organizations;organizational readiness;Outcome;outreach;Pathway interactions;physical conditioning;post-traumatic stress;prevent;Process;promote resilience;Protocols documentation;Public Health;public health relevance;Quality of life;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;Research Priority;resilience;Resource-limited setting;Resources;response;revictimization;Risk;Safety;Schools;Science;secondary outcome;Secure;Self Efficacy;Services;Severities;sexual and reproductive health;Sexual Health;Shame;Social Impacts;Source;structural determinants;Support System;Surveys;Survivors;System;Technology;technology intervention;technology validation;Training;Translating;Trauma;trend;underserved area;Universities;Violence;violence prevention;volunteer;web app;web site;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Dissemination, Implementation, and Effectiveness of an Intervention to Prevent Intimate Partner Violence

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Neurosciences

PHR: Brain metastasis (BM), frequently arising in patients with metastatic non-small cell lung cancer and melanoma, is the most common cause of cancer-related deaths in the US, yet our molecular understanding of human BM is rudimentary. Here, we employ several innovations to dissect cellular, molecular and microenvironmental mechanisms that drive metastasis. These will reveal novel vulnerabilities that may be therapeutically targeted.

PI_NAMEs: IZAR, BENJAMIN  (contact);LAUGHNEY, ASHLEY MARIE

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Adenosine;Advanced Malignant Neoplasm;Affect;analytical tool;Aneuploidy;Antibodies;Biological Assay;Biology;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;case control;Cell Communication;Cell Compartmentation;Cell Physiology;cell type;Cells;Cephalic;Cessation of life;Chromosomal Instability;Chronic;Clinical;Clinical Trials;clinically significant;cohort;Communities;Coupled;Cytosol;Data;Data Set;debilitating symptom;Dependence;Development;Disease;ds-DNA;Ecosystem;ecto-nucleotidase;effective therapy;Environment;Evolution;Exclusion;Exhibits;exome sequencing;Functional Imaging;Genes;Genetic;Genomics;Genotype;Goals;Heterogeneity;Human;human data;human model;Hydrolysis;Immune;immune cell infiltrate;Immune response;Immune System Diseases;Immunocompetent;Immunocompromised Host;Immunofluorescence Immunologic;improved;In Situ;in vivo;in vivo Model;Innate Immune Response;innovation;insight;Knock-out;Knowledge;KRAS2 gene;Label;Ligands;Link;Lung Carcinoma;Lymphoid;Malignant Neoplasms;Maps;Measures;Melanoma;Metabolic;Metastatic malignant neoplasm to brain;Methods;micronucleus;Modeling;Modernization;Molecular;mouse model;multimodality;Mus;Mutation;Myelogenous;Nature;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;Patients;Phenotype;Primary Neoplasm;Prognosis;programs;Research;response;RNA;Role;Rupture;Sampling;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;spatiotemporal;Specimen;Stains;Stimulator of Interferon Genes;STK11 gene;System;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic development;therapeutic target;therapy resistant;Tissues;transcriptome sequencing;transcriptomics;tumor;tumor microenvironment;Tumor-Derived;tumorigenic;Validation;Work

PROJECT_TITLE: Multi-cellular interactions defining the human brain metastatic niche

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Shorter, well-tolerated, and efficacious rifamycin-free regimens for the treatment of drug-susceptible tuberculosis (TB) are critically needed to attain the World Health Organization targets towards TB elimination. Using a novel artificial-intelligence-enabled parabolic response surface platform, we identified an experimental regimen comprising bedaquiline, clofazimine, pyrazinamide, and delamanid (BCZD), which achieved relapse- free cure in 3 weeks in mouse models. Based on this compelling pre-clinical data, and established safety profile of constituent drugs, we propose a Phase IIc, open-label, randomized controlled trial to investigate the efficacy and safety of an 8-week regimen of BCZD compared to standard therapy for drug-sensitive TB, paving the way for a definitive treatment-shortening trial and potentially shifting clinical practice.

PI_NAMEs: KOENIG, SERENA PATRICIA (contact);WASSERMAN, SEAN ADAM

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Address;Adult;Adverse event;adverse event monitoring;Aftercare;antiretroviral therapy;Artificial Intelligence;bactericide;Biological;Characteristics;Clinical;Clinical Data;clinical practice;clinical research site;Clinical Trials;Combined Modality Therapy;Confidence Intervals;Country;Data;Data Collection;design;Dose;Drug Combinations;Drug Exposure;Drug Interactions;Drug Kinetics;drug repurposing;Drug resistance;drug standard;drug-sensitive;efficacy trial;Evaluation;experimental study;follow-up;Frequencies;Future;genome sequencing;Goals;Guidelines;Haiti;hazard;Hepatitis;high throughput screening;HIV;HIV Seropositivity;HIV/TB;Inbred BALB C Mice;Individual;Infrastructure;Laboratory Procedures;Liquid substance;Lung;Measures;Methods;Minimum Inhibitory Concentration measurement;Monitor;mouse model;Mus;mycobacterial;novel;open label;Outcome;Participant;patient population;Patients;Pharmaceutical Preparations;pharmacokinetic model;Phase;Phenotype;Population;pre-clinical;preclinical evaluation;Predisposition;Probability;Process;Pyrazinamide;Randomized;Randomized, Controlled Trials;Regimen;Relapse;research clinical testing;Resistance;resistance frequency;resistance mutation;response;Rifampin;Rifamycins;risk sharing;Safety;safety assessment;Sample Size;Skin;South Africa;standard care;Surface;Testing;Time;Translating;Translations;treatment adherence;treatment arm;treatment duration;Treatment Failure;Treatment Protocols;treatment response;Tuberculosis;tuberculosis drugs;tuberculosis treatment;whole genome;Width;World Health Organization

PROJECT_TITLE: PRESCIENT: A phase IIc, open-label, randomized controlled trial of ultra-short course bedaquiline, clofazimine, pyrazinamide and delamanid versus standard therapy for drug-susceptible tuberculosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric - AIDS;Precision Medicine;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Current approaches to diagnosis and management of children < 5 years that are at high risk of TB and have a high case-fatality rate are inadequate. We anticipate promising integrated biomarkers that will transform public health and clinical interventions in this most vulnerable population by providing novel approaches to risk-stratify children <5 years of age at risk for TB for targeting the administration of preventive therapy and ATT.

PI_NAMEs: JOHNSON, WILLIAM EVAN;SALGAME, PADMINI  (contact);SONG, RINN

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Adult;age group;Antibodies;antigen-specific T cells;Antigens;Antitubercular Agents;aptamer;aspirate;Bacteriology;Biological;Biological Assay;Biological Markers;biomarker signature;Biophysics;Blood;Caring;Case Fatality Rates;Categories;Cells;Child;Childhood;Clinic;Clinical;clinical decision-making;Cohort Studies;computer aided detection;Cytometry;Decision Trees;Detection;Diagnosis;Diagnostic;Disease;Enzyme-Linked Immunosorbent Assay;Evaluation;exosome;Exposure to;extracellular vesicles;Gene Expression Profile;Goals;Heterogeneity;high dimensionality;high risk;HIV;Image;imaging biomarker;imaging modality;improved;Infection;Intervention;isoniazid;Laboratories;Locales;lymphadenopathy;Machine Learning;Mass Spectrum Analysis;Mediastinal;Modeling;multiple omics;Mycobacterium tuberculosis;nano-string;nanoengineering;novel;novel diagnostics;novel strategies;Peptides;Performance;point of care;Population;predictive marker;Preventive therapy;progression marker;progression risk;proteomic signature;Proteomics;Public Health;Reference Standards;Research Personnel;Risk;risk stratification;screening;Serum;single cell analysis;Specimen;Sputum;Stomach;Symptoms;T memory cell;T-Cell Activation;T-Lymphocyte Subsets;Testing;Thoracic Radiography;Training;transcriptome sequencing;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Uganda;Ultrasonography;ultrasound;Vulnerable Populations;X-Ray Medical Imaging

PROJECT_TITLE: Biomarker Signatures of TB Infection in Young Children With and Without HIV


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative The Mexican American population in the U.S. is rapidly growing and aging. This project will study the relative development and long-term progression of cognitive impairment and dementia in Mexican Americans and non- Hispanic whites. It will also study the effects on caregivers faced with critical life decisions.

PI_NAMEs: MORGENSTERN, LEWIS B (contact);ZAHURANEC, DARIN B

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acculturation;adverse outcome;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Caregiver Burden;Caregivers;caregiving;Caring;clinical care;Cognitive;cohort;Communities;comorbidity;Complex;cost;County;culturally appropriate intervention;Data;Decision Making;Dementia;Development;Diagnosis;Disadvantaged;Discipline of Nursing;Disease;Disparity;economic impact;Economics;Employment Status;end of life;ethnic disparity;Ethnic Origin;Explosion;Family;Family Caregiver;family support;Financial Hardship;follow-up;Future;Growth;Health;Home;Impaired cognition;in-home care;Individual;instrument;intergenerational;Intervention;Knowledge;Life;loved ones;Measures;Medical;Mental Health;Mexican Americans;Minority Groups;Not Hispanic or Latino;Nursing Homes;Patients;Personal Satisfaction;Persons;Physicians;Policies;Policy Making;Population;population based;Population Heterogeneity;Population Study;preference;Prevalence;public health priorities;Public Policy;Questionnaires;Safety;Skilled Nursing Facilities;Socioeconomic Factors;socioeconomics;Texas;therapy design;Time;United States

PROJECT_TITLE: Critical Decision Making in Alzheimer's Disease and Related Dementias in Mexican Americans

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Microbiome;Prevention;Substance Misuse

PHR: Project Narrative  As a worldwide healthcare burden, alcohol consumption ranks as the 7th leading risk factor of death, accounting for 6.8% and 2.2% of deaths in men and women, which resulted in 3 million deaths in 2016 as estimated by WHO and cost 249 billion dollars in United States in 2010. Alcohol, as a leading cause of liver disease, is associated with a wide spectrum of hepatic diseases, such as alcohol-associated steatosis, steatohepatitis, fibrosis, cirrhosis, alcoholic hepatitis, and triggers weakening of the immune system escalating the susceptibility of bacterial and viral infections. Understanding the intestinal immune system to regulate systemic inflammation and infection is critical to design preventive and interventional therapies to counteract alcohol-associated liver disease.

PI_NAMEs: LLORENTE IZQUIERDO, ANA CRISTINA (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Accounting;Acetylcholine;adaptive immune response;Adaptive Immune System;Address;Agonist;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol prevention;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Antigen Presentation;Antigen-Presenting Cells;Antigens;Bacteria;Bacterial Infections;Bacterial Translocation;Cell Count;Cells;Cellular biology;Cessation of life;Chronic;chronic alcohol ingestion;chronic liver disease;chronic liver inflammation;Cirrhosis;Colon;Complex;cost;Data;Dendritic Cells;design;Diet;Down-Regulation;dysbiosis;Energy-Generating Resources;Epithelial Cells;Equilibrium;Ethanol;Exposure to;feeding;Fibrosis;Flow Cytometry;Functional disorder;gain of function;Generations;Genes;Goals;Goblet Cells;Growth;gut dysbiosis;gut microbiota;gut-liver axis;healthcare burden;Human;IL6ST gene;Immune;Immune response;Immune system;Immunity;immunoregulation;imprint;In Vitro;in vivo;Inflammation;inhibitor;Innate Immune System;innovation;Interleukin-6;Intervention;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Lamina Propria;Liver;Liver diseases;loss of function;Mediating;men;Messenger RNA;microbial;microbiome research;microbiota composition;microorganism antigen;Modeling;Monitor;Mucin-2 Staining Method;Mucins;Mucosal Immune System;Mucous body substance;Mus;Muscarinic Acetylcholine Receptor;Myelogenous;Nature;pathogen;Pathogenesis;Patients;pharmacologic;Play;population health;positive allosteric modulator;Pre-Clinical Model;Predisposition;prevent;Prevention;Preventive therapy;Production;Property;Regulation;Research;Resistance;response;Risk Factors;Role;Shapes;Signal Pathway;Signal Transduction;Small Intestinal Goblet Cell;Steatohepatitis;Systemic infection;systemic inflammatory response;Technology;Therapeutic;Therapeutic Intervention;Time;Transducers;United States;Virus Diseases;Western Blotting;Wild Type Mouse;Woman

PROJECT_TITLE: Goblet cells and intestinal immune response in alcohol-associated liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]