NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Chronic Obstructive Pulmonary Disease;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Individuals with chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality in the United States, are at high risk for financial burden. Financial toxicity, which is the objective financial burden and subjective financial distress resulting from treatment, has been associated with worse health outcomes in other chronic medical conditions, but its impact in COPD has not been studied. The proposed study will use quantitative and qualitative methods to assess the association between financial toxicity from treatment of COPD and patient outcomes, with the ultimate goal of identifying potential areas to mitigate the adverse impact of financial toxicity.

PI_NAMEs: MALLYA, SONAL  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acute;Adherence;Adverse effects;Affect;American;Area;Behavioral;Bronchodilator Agents;burden of illness;Cardiovascular Diseases;career;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Complex;cost;Data;Data Collection;Diabetes Mellitus;Diagnosis;Direct Costs;disability;Disease Outcome;Economic Burden;Emergency department visit;Expenditure;experience;Family;Financial Hardship;financial toxicity;Funding;Future;Goals;Health;Health Care Costs;health care service utilization;health disparity;Health Expenditures;health related quality of life;Health Services;Health Status;high risk;Hospitalization;Household;improved outcome;Income;Individual;Inhalation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Longitudinal cohort;Malignant Neoplasms;Measures;Medical;Medical Care Costs;medication compliance;Morbidity - disease rate;mortality;Observational Study;Occupational activity of managing finances;Outcome;Participant;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacy facility;poor health outcome;Population;Progressive Disease;Provider;psychologic;Qualitative Methods;Reporting;Research;Research Personnel;Risk;Role;Self Management;skills;social health determinants;Structure;Surveys;Time;Training;Treatment Cost;Treatment-related toxicity;trend;Uninsured Medical Expense;United States;Work

PROJECT_TITLE: Financial Toxicity in Chronic Obstructive Pulmonary Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Suicide is a leading cause of death in the U.S. and worldwide, with an even larger number of people experiencing suicidal thoughts and behaviors (STBs); however, extant (brief and traditional) treatments appear to have a limited impact on suicidal ideation. Focusing on the core mechanisms that give rise to suicidal ideation, as an “upstream” target that may have an impact on suicide attempts and deaths “downstream,” may represent a more potent and parsimonious approach to care. The proposed project will address the critical need of integrating established suicide-specific mechanisms that maintain suicidal ideation into a disseminable intervention for STBs.

PI_NAMEs: FRUHBAUEROVA, MARTINA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Address;Admission activity;Ambulatory Care;Appointment;Automobile Driving;Behavior;Belief;brief intervention;career;Caring;Cause of Death;Clinical;Clinical Trials;Coping Skills;Data;Development;Dimensions;Dose;Environment;experience;Feeling;Feeling hopeless;Feeling suicidal;follow up assessment;follow-up;Future;Goals;high risk;Hospitals;ideation;implementation intervention;improved;Individual;Inpatients;Intervention;Learning;Length;Life;Link;Literature;Maintenance;Mental Health;Mentorship;National Institute of Mental Health;novel;Outpatients;Participant;Patient Admission;Patient Self-Report;Patients;Persons;Physicians;post intervention;prevent;preventive intervention;Process;Provider;psychiatric inpatient;Public Health;Randomized;Randomized, Controlled Trials;reducing suicide;Research;research and development;Research Domain Criteria;Role;Safety;Scientist;skills;social;Social Perception;suicidal;suicidal act;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Testing;Theoretical model;theories;therapy development;Thinking;Time;treatment as usual;treatment disparity;treatment effect;Uncertainty;United States;virtual;Work

PROJECT_TITLE: Randomized controlled trial of a single-session mechanism-focused intervention for suicidal thoughts and behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Depression;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Adult hippocampal neurogenesis is a unique form of brain plasticity that plays an important role in hippocampal functions that are known to be affected in FASD (I.e., learning, memory and mood regulation). Prior work has demonstrated a profound effect of developmental alcohol exposure on the ability to mount a neurogenic response to enriched environment. In this proposal, I will test whether this impaired neurogenesis can be remediated through pharmacological, genetic and/or chemogenetic manipulations.

PI_NAMEs: RODRIGUEZ, ARASELY M (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adult;adult neurogenesis;adult stem cell;Affect;Agonist;alcohol consumption during pregnancy;alcohol exposure;alcohol measurement;alcohol research;Alcohols;Animal Model;anti-depressive agents;Anxiety;Apoptosis;Apoptotic;BAX gene;Behavioral Assay;behavioral outcome;Brain;brain dysfunction;Brain region;Brain-Derived Neurotrophic Factor;Child;Childhood;Chronic;Clinical;comparison control;cost;Cytoplasmic Granules;depressive symptoms;design;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Discrimination Learning;drinking;Environment;environmental enrichment for laboratory animals;experimental study;Exposure to;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fluoxetine;Fright;Functional disorder;Functional impairment;Future;Genes;Genetic;genetic approach;genetic manipulation;Goals;granule cell;Hippocampus;Histologic;House mice;Impairment;improved;Inhibition of Apoptosis;Intervention;Knockout Mice;learned behavior;Learning;life span;Mediating;Memory;Mental Depression;Mission;Modeling;mood regulation;mouse model;Mus;N-Methylaspartate;National Institute on Alcohol Abuse and Alcoholism;nerve stem cell;neurogenesis;neuron apoptosis;Neurons;Neurosciences;New Mexico;Newborn Infant;newborn neuron;Outcome;Outcome Measure;pharmacologic;Play;Population;pre-clinical;Pregnancy;Process;progenitor;Proliferating;Public Health;remediation;Reporting;Research;response;Role;Selective Serotonin Reuptake Inhibitor;social;Symptoms;Synapses;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;Transgenic Mice;treatment strategy;Woman;Work

PROJECT_TITLE: Therapeutic Targeting of Adult Hippocampal Neurogenesis in a Mouse Model of FASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Errors during human eye development can vary and are widely disparate, arising from mutations affecting this tightly regulated process and can severely affect vision at birth. This proposal seeks to characterize a rare syndromic case study of a sex-reversed XX male child born with no eyes and focal brain abnormalities, that resulted most strikingly from a mutation that occurs at the exact genomic site previously associated with numerous other different disorders. The aims herein will utilize cells obtained from the patient to survey how their mutation affected their genetic architecture and if their mutated cells are able to recapture how their eye development went awry in vitro, as well as utilization of mice that have been genetically engineered to replicate the absence of the eyes for cellular analysis.

PI_NAMEs: ROSAS, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;9q21;Address;Adopted;Affect;Anatomy;Anophthalmos;Antibodies;Apical;Architecture;arm;autosome;Back;Base Pairing;Bilateral;Birth;Blindness;Blood Cells;Body System;Brain;brain abnormalities;brain magnetic resonance imaging;Case Study;Cations;cell type;Cells;Cellular Morphology;Centromere;Child;Choroid;Choroid Plexus Epithelium;Chromatin;Chromosome 9;Chromosome Arm;Coloboma;Complement;Complex;Congenital Abnormality;Congenital Disorders;de novo mutation;Development;Developmental Process;Disease;disease phenotype;Disparate;DNA Sequence Alteration;Doxycycline;Dysmorphology;Encapsulated;Enhancers;Etiology;Exons;Eye;Eye Development;fascinate;Female;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;genetic architecture;Genetic Engineering;Genetic Transcription;genome-wide;Genomics;Gonadal structure;Health;Heterogeneity;Hi-C;Human;Hypertrichosis;Hypoparathyroidism;Immunohistochemistry;Impairment;In Vitro;in vivo;indexing;induced pluripotent stem cell;insight;Ion Channel;Kinetics;Left;Lesion;Link;Live Birth;lymphoblast;male;malformation;Maps;Measures;Mediating;Meiosis;metaplastic cell transformation;Methods;Microphthalmos;Modality;Molecular;monolayer;Mosaicism;mouse model;Mus;Mutate;Mutation;Nature;Neural Retina;Neurons;Nociception;Nodal;Nucleic Acid Regulatory Sequences;Organ;Pathogenesis;Pathologic;Pathology;Patients;Phenotype;Photoreceptors;Physiological;proband;Process;promoter;Proteins;Regulatory Element;Regulatory Pathway;Reporting;Research;response;Retina;sertoli cell;sex;Signal Pathway;single cell sequencing;single-cell RNA sequencing;Site;Source;Specific qualifier value;Structural defect;Structure of choroid plexus;Structure of retinal pigment epithelium;Surveys;Syndrome;System;Testing;Tissues;Training;transcription factor;transdifferentiation;Transgenes;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Vision;Visual Fields;Visual Perception;X Chromosome;X Inactivation;XX male

PROJECT_TITLE: Transcriptional and Developmental Basis of the Human X-linked Homeotic Hotspot

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Infectious Diseases

ORG_CITY: Nashville

ORG_DEPT: PATHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Deleted in Malignant Brain Tumors 1 (DMBT1) is a large, secreted glycoprotein that may represent a critical link between inflammation, infection, and colorectal cancer (CRC). The proposed research will investigate the mechanism of DMBT1 loss in colorectal dysplastic transformation and determine if DMBT1 loss is advantageous for CRC progression through changes in epithelial cell survival, proliferation, differentiation, and migration potential. Understanding the molecular relationships between immune barrier function and the regulation of epithelial homeostasis will ultimately improve CRC biomarker discovery and precancer diagnostics.

PI_NAMEs: GREEN, EMILY H (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affect;Anti-Bacterial Agents;Apical;Azoxymethane;Bacteria;Bacterial Infections;bacterial resistance;beta catenin;Biochemical;Biological Assay;Biological Markers;biomarker discovery;Cancer Etiology;Cell Differentiation process;cell growth;Cell Nucleus;Cell Polarity;Cell Survival;Cells;Cessation of life;Clinical;Clostridium difficile;Colon;colon dysplasia;colon tumorigenesis;Colonic Polyps;Colorectal;Colorectal Cancer;colorectal cancer progression;CRISPR/Cas technology;Critical Pathways;Cytoplasm;Data;deletion analysis;Development;Diagnostic;Disease Progression;Distal;DMBT1 gene;Down-Regulation;Dysplasia;early detection biomarkers;early onset colorectal cancer;Embryonic Development;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;epithelial to mesenchymal transition;Epithelium;extracellular;Family;Gastric Adenocarcinoma;Gastric Metaplasia;gastrointestinal epithelium;gastrointestinal infection;Gastrointestinal tract structure;genetic manipulation;Genetic Transcription;glycoprotein 340;Glycoproteins;Goals;High grade dysplasia;Homeostasis;Human;Human Cell Line;Immune;Immune signaling;Immunofluorescence Immunologic;Immunofluorescence Microscopy;improved;In Situ;in vivo;Infection;Inflammation;Inflammatory Bowel Diseases;Invaded;kidney repair;Knock-out;Lesion;Link;Literature;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mesenchymal;migration;Modeling;Molecular;Mouse Cell Line;mouse model;Mus;neoplastic cell;Newly Diagnosed;Organoids;pathogen;Pathology;Pathway interactions;Pleomorphism;premalignant;Process;Proliferating;protein expression;Proteins;Publishing;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;Research;response;Role;Sampling;Signal Pathway;Site;Sodium Dextran Sulfate;SRCR proteins;Stains;STAT3 gene;Testing;timeline;Tissue Microarray;Tissues;Toll-like receptors;transcriptomics;Transforming Growth Factor beta;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Deleted in malignant brain tumors 1 (DMBT1) expression and impact on colonic dysplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Microbiome;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Completing these studies will provide novel insight into differential gut microbiota communities on malaria vaccine-induced immunity and whether US gut microbiomes affect vaccine-induced immunity differently than African gut microbiomes. These data are likely to be of high impact to the malaria vaccine community and broader vaccine development.

PI_NAMEs: SCHMIDT, NATHAN  (contact);SRINIVASAN, PRAKASH

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Adult;Affect;Africa;African;Animal Model;Antibiotic Therapy;Antibody Response;Antibody titer measurement;Blood;Breeding;Child;Communities;Data;Development;Distal;efficacy outcomes;Environmental Risk Factor;Erythrocytes;European;Germ-Free;Gnotobiotic;gut bacteria;gut microbiome;gut microbiota;Hepatocyte;Heterogeneity;Human;Immune response;Immune system;Immunization;Individual;Infection;insight;Integration Host Factors;Intervention Studies;Investigation;Laboratories;Malaria Vaccines;malarial anemia;Mediating;microbiome;microbiota composition;mouse model;Mus;novel;Observational Study;Parasite Control;Parasites;Pattern recognition receptor;Plasmodium falciparum;Plasmodium yoelii;Population;pre-clinical;protective efficacy;Reaction;response;Role;Shapes;Signal Pathway;Sporozoites;stool sample;Structure of germinal center of lymph node;Target Populations;Testing;vaccine candidate;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Vendor

PROJECT_TITLE: Effect of gut microbiota composition on malaria vaccine-induced immune responses

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: COMPUTER CENTER

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: IRVINE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Optic neuropathies, a group of disorders leading to irreversible vision loss due to retinal ganglion cell degeneration and optic nerve damage, present a significant challenge in ophthalmology, primarily due to delayed diagnosis and diverse etiologies. This research aims to investigate the detection and management of these diseases by harnessing deep learning and computational techniques to analyze optical coherence tomography (OCT) data. By developing precise biomarkers and utilizing advanced methods like deep generative models, geometric modeling, and neural fields, the project seeks to improve early diagnosis, accurately predict disease progression, and facilitate personalized treatment strategies, addressing the critical need for timely intervention in optic neuropathies.

PI_NAMEs: KHOSRAVI, POOYA  (contact)

PROJECT_TERMS: Address;Affect;Biological Markers;Blindness;Categories;Characteristics;Chronic Disease;Classification;Complex;Computational Technique;Data;Dedications;deep learning;deep learning algorithm;deep learning model;Dependence;design;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Dimensions;Disease;Disease Management;Disease Progression;Early Diagnosis;Etiology;Eye diseases;field study;Foundations;generative models;geometric structure;Glaucoma;Goals;high resolution imaging;Image;Image Analysis;image registration;Imagery;imaging modality;Imaging Techniques;improved;Individual;Inflammatory;Inherited;innovation;insight;Intervention;Ischemia;joint function;Joints;large datasets;Lead;longitudinal analysis;macula;Maps;Measurement;Medical Imaging;Methods;Modality;Modeling;Monitor;morphometry;nerve damage;neural;Neuropathy;next generation;non-invasive imaging;novel;novel marker;novel therapeutics;Ophthalmology;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Outcome;Patient-Focused Outcomes;Pattern;personalized medicine;predictive modeling;Research;Resolution;Retina;retinal ganglion cell degeneration;retinal imaging;retinal nerve fiber layer;Scanning;Scotoma;Signal Transduction;stem;Structure;Structure-Activity Relationship;success;Techniques;Testing;Thick;Time;Training;trait;treatment response;treatment strategy;Visual Fields;Visualization

PROJECT_TITLE: Deep Learning-based retinal optical coherence tomography markers for optic neuropathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Influenza viruses are a serious threat to human health. Here, I propose to develop new methods to assess the pandemic potential of influenza viruses. These methods could help guide research and public health interventions and could also be applied to other emerging viral threats.

PI_NAMEs: SOMSEN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Affect;Animal Model;Animals;Assessment tool;Centers for Disease Control and Prevention (U.S.);Cessation of life;comparative;Complex;Consumption;current pandemic;Data;Data Set;Data Sources;emerging virus;Epidemic;epidemic virus;epidemiological model;Epidemiology;Evolution;experimental study;Family suidae;Ferrets;Formulation;gene environment interaction;Generations;Genes;Genetic;Genetic Risk;Health;HIV;Human;human mortality;human pathogen;Immunity;improved;In Vitro;in vivo;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza virus strain;influenzavirus;interest;Laboratories;mathematical model;Mathematics;Measures;Methods;Modeling;Mutation;new pandemic;novel;novel strategies;novel virus;pandemic disease;pandemic influenza;pandemic potential;Parameter Estimation;pathogen;pathogenic virus;Phylogenetic Analysis;Phylogeny;Population;Probability;Public Health;public health intervention;Recording of previous events;Reproduction;reproductive;Research;Risk Assessment;risk prediction;SARS-CoV-2 infection;seasonal influenza;Serology;Signal Transduction;simulation;Speed;success;System;Testing;theories;therapeutic development;therapy development;Time;tool;Training;trait;transmission process;Vaccines;Variant;Viral;viral pandemic;Virus;Virus Diseases;whole genome;wild bird;Work;zoonotic spillover

PROJECT_TITLE: Developing novel methods to assess the pandemic potential of influenza A viruses using mathematical modeling and evolutionary methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proper maintenance of “immortal” cell populations like adult stem cells is important to prevent cell overproliferation (cancer) or cell degeneration and loss (premature aging). Adult stem cells in both humans and flies undergo asymmetric cell division to maintain stem cells while creating differentiating cells, and epigenetics underlie these different cell fate decisions. Here I propose studying the role of chromatin and DNA replication timing on asymmetric histone incorporation to better understand how epigenetic asymmetry can be established and regulated to produce substantially different cell fates and ensure proper cell maintenance and homeostasis.

PI_NAMEs: DAVIS, BRENDON EUGENE MICHAEL (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: adult stem cell;Affect;Architecture;ATAC-seq;cancer stem cell;Cell Cycle;Cell Differentiation process;Cell division;cell fate specification;Cell Maintenance;cell type;Cells;Chromatin;Chromatin Fiber;Chromatin Structure;chromosome replication;Coupled;daughter cell;Development;Developmental Biology;differential expression;Disease;DNA;DNA biosynthesis;DNA polymerase A;DNA Polymerase I;DNA replication fork;DNA Replication Timing;Drosophila genus;Ensure;Environment;Epigenetic Process;epigenome;Euchromatin;Eukaryota;Eukaryotic Cell;experience;Fertility;Fiber;fly;Gene Expression;Gene Expression Regulation;Genes;genetic information;Genetic Transcription;Genome;Genomic Segment;Germ Lines;germline stem cells;Heterochromatin;Histone H3;Histone H4;histone modification;Histones;Homeostasis;Human;hydroxyurea;Individual;Inheritance Patterns;Inherited;interest;Knock-out;Knowledge;Label;Link;Maintenance;male;Malignant Neoplasms;Measures;Mitosis;Mitotic;Modeling;Movement;Nuclear RNA;Pattern;Play;Population;Premature aging syndrome;Prevalence;prevent;Process;programs;Proliferating;Proteins;recruit;Recycling;regenerative;Regulation;Role;Rosaniline Dyes;S phase;segregation;self-renewal;single molecule;small molecule;Specific qualifier value;Spermatogenesis;Spermatogonia;stem cell biology;stem cell differentiation;stem cell division;stem cells;stemness;superresolution microscopy;System;telophase;Testis;Time;Time Factors;transcriptome sequencing;Visualization;Work

PROJECT_TITLE: Mechanism and Regulation of Replication-Coupled Asymmetric Histone Incorporation in Drosophila Male Germline Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative Patients with unresectable, intrahepatic cholangiocarcinoma have poor overall survival. We propose to examine the clinical activities and immune effect of a novel combination therapy using radiation followed by intratumor injection of autologous dendritic cells followed by systemic infusion of checkpoint inhibitors to PD-L1 and TIGIT.

PI_NAMEs: LIN, YI ;PARK, SEAN S (contact);ROBERTS, LEWIS R

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Antigen Presentation;Autologous Dendritic Cells;Blood;CD14 gene;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cellular Immunity;checkpoint inhibition;checkpoint receptors;chemotherapy;Cholangiocarcinoma;Cisplatin;Clinical;clinical efficacy;Clinical Trials;Clonal Expansion;Combination Drug Therapy;Combination immunotherapy;Combined Modality Therapy;Correlative Study;curative treatments;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Disease;disorder control;Dose;Dose Limiting;exhaustion;Galactose Binding Lectin;gemcitabine;Image Cytometry;Immune;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;in vivo;Inflammatory;Infusion procedures;inhibitor;Injections;innovation;insight;Intervention;Intrahepatic Cholangiocarcinoma;Investigation;Liver;Liver Failure;Liver neoplasms;liver transplantation;Malignant Neoplasms;manufacture;Mediating;Methods;monocyte;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;National Comprehensive Cancer Network;neoantigens;neoplastic cell;novel;novel therapeutics;Operative Surgical Procedures;palliation;palliative;partial response;Patients;Phase;phase 2 study;Phase II Clinical Trials;Pilot Projects;Primary carcinoma of the liver cells;primary endpoint;Primary Malignant Neoplasm of Liver;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Radiation;Radiation therapy;Recommendation;Reporting;Resistance;resistance mechanism;response;Risk;Running;Safety;Serious Adverse Event;Signal Transduction;single-cell RNA sequencing;spatial relationship;Stable Disease;Systemic Therapy;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technology;Testing;therapeutic development;Tissues;Toxic effect;transcriptome;tumor;Tumor Antigens;Tumor Expansion;Tumor-Derived;Unresectable;Up-Regulation;uptake;Vertebral column

PROJECT_TITLE: Radiation and dendritic cell combination to improve immunotherapy response in intrahepatic cholangiocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-B (02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE DNA replication timing links genome regulation and stability is modulated during development, and is altered in cancer and other genetic diseases. We propose to measure replication timing in unprecedented scale across humans, identify sequence elements that control DNA replication timing, and link it to gene and epigenome regulation in novel ways. The insights obtained from this project will inform the understanding of the molecular mechanisms and functional consequences of DNA replication timing.

PI_NAMEs: KOREN, AMNON  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Award;Biological Assay;Biology;cancer genetics;Cell Differentiation process;Cells;Chromosome Mapping;Communication;Data Set;Development;DNA biosynthesis;DNA Replication Timing;DNA Sequence;Elements;epigenome;epigenomics;Experimental Genetics;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Variation;Genome;genome resource;Genome Stability;genome-wide;Genomic approach;Human;human DNA;Human Genetics;insight;Link;Measures;Molecular;Mutation;Nature;novel;novel strategies;Other Genetics;programs;Regulation;S phase;spatiotemporal;Specific qualifier value;success;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: The Genetic Basis of Human DNA Replication Timing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE This project is related to public health as it will examine the structure of a pivotal viral protein involved the in replication and pathogenesis of herpes simplex virus. Results from this proposal can be used to develop new therapies for preventing or treating herpetic diseases, which is within NIH’s mission to promote scientific discovery while enhancing human health.

PI_NAMEs: BLOOM, DAVID C.;DAVIDO, DAVID J (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acute infection;Address;Afferent Neurons;Amino Acids;Animal Model;Binding;Biological Assay;Blindness;C-terminal;Cell Culture Techniques;cell injury;Cells;Crystallization;Databases;Development;dimer;Dimerization;Disease;Encephalitis;Event;experimental study;Eye Infections;Fibroblasts;Gene Expression;Genes;Genetic study;Genetic Transcription;genital infection;Goals;Growth;Health;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Homologous Gene;Human;Immediate-Early Proteins;Impairment;Infection;inhibitor;innovation;insight;Knowledge;Laboratories;latent infection;Life;Life Cycle Stages;Link;Lytic Phase;lytic replication;Mediating;Mission;Modeling;Molecular;Molecular Structure;Mus;mutant;Mutation;Neurons;novel;novel therapeutics;oral infection;Orthologous Gene;Pathogenesis;Play;prevent;Process;Productivity;promoter;protein activation;protein protein interaction;Proteins;Public Health;reactivation from latency;Recurrence;Reporter;Research;Resolution;Roentgen Rays;Role;Simplexvirus;Site;Structure;Testing;therapeutically effective;Transactivation;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Viral;Viral Genes;Viral Interference;Viral Pathogenesis;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work;work-study

PROJECT_TITLE: Role of ICP0 Dimerization in Herpes Simplex Virus Pathogenesis

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Endocannabinoid System Research;Mental Health;Natural Products;Neurosciences;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Narrative This NRSA F30 fellowship will provide an invaluable and comprehensive training opportunity for a future physician-scientist as she develops into an emerging leader in the field of alcohol research and clinical neuroscience. These studies investigate important interactions among alcohol, cannabis, and pain in both animals and humans. Findings from this research will provide valuable insight for future translational studies and therapeutic applications aimed at alleviating alcohol use disorder (AUD)-associated pain.

PI_NAMEs: LEE, SUMIN  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;addiction;Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol measurement;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Analgesics;Animal Model;Animals;associated symptom;Behavior;biobehavior;Biological Markers;Brain region;Cannabinoids;Cannabis;career;career development;Chemosensitization;Chronic;Chronic inflammatory pain;chronic pain;chronic pain management;Clinical;clinical investigation;cohort;Cohort Studies;Data;Data Analyses;Data Set;Dependence;Development;disorder risk;Dose;drinking;emotional symptom;Endocannabinoids;endogenous cannabinoid system;Ethanol;Exhibits;Fellowship;Female;Frequencies;Funding;Future;Health;Heavy Drinking;HIV;Human;Hyperalgesia;Hypersensitivity;Incidence;indexing;Individual;insight;Intervention;Investigation;Knowledge;Letters;longitudinal analysis;male;marijuana use;marijuana use disorder;Measures;Mechanics;Medical Marijuana;men;Mental disorders;Motivation;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;negative affect;Neurobiology;Neurons;Neurosciences;Neurosciences Research;Nociception;Outcome;Pain;Pain management;pain reduction;pain sensitivity;pain symptom;Pathway interactions;Patient Self-Report;Persistent pain;Persons;pharmacologic;Pharmacological Treatment;phosphatidylethanol;Physicians;Play;Population;pre-clinical;Procedures;protein expression;Proteomics;Rattus;Recording of previous events;Recreation;Regression Analysis;Research;Research Training;Risk;Role;Scientist;Self Administration;Severities;sex;Site;Stress;Substance Use Disorder;summer research;Synapses;System;Testing;Tetrahydrocannabinol;Training;training opportunity;Translational Research;translational study;translational therapeutics;Treatment Efficacy;United States;United States Substance Abuse and Mental Health Services Administration;vapor;Withdrawal;Woman;Work

PROJECT_TITLE: Alcohol-Cannabinoid System Interactions in the Context of Pain and AUD


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Pediatric;Physical Rehabilitation;Rare Diseases;Regenerative Medicine;Rehabilitation;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE There is an urgent need for valve replacements capable of growth and self-repair for children born with congenital valve disease, for whom the current standard of care is multiple cardiac surgeries throughout their lifetime to repair or replace structurally-degraded valve replacements. Living allogenic valve transplantation has recently emerged as a means of delivering valve replacements with the capacity for growth and self-repair, but its utility is restricted by the limited viability of valve tissue ex vivo. This proposal aims to overcome this limitation by developing a strategy for the ex vivo preservation of living allogenic heart valves for at least 3 weeks, enabling their off-the-shelf availability.

PI_NAMEs: CORDOVES, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Academic Medical Centers;adverse outcome;Allogenic;Allografting;Antibiotic Therapy;Apoptosis;Apoptotic;Architecture;Biochemical;Biological;Biological Process;Biomimetics;Bioreactors;calcification;Cardiac Surgery procedures;Cells;cellular engineering;Child;Childhood;Clinical;clinical implementation;congenital heart abnormality;Congenital Heart Defects;Control Groups;cost;cost effectiveness;Cryopreservation;Cues;Custom;design;Development;Disease;Elements;Engineering;Environment;experience;Extracellular Matrix;Failure;Family suidae;Fellowship;Fibrosis;Goals;Growth;Harvest;Heart;Heart Valve Diseases;heart valve replacement;Heart Valves;Homeostasis;homograft;Human;Immune response;immunogenicity;Immunologics;immunoreaction;Immunosuppression;Implant;improved;in vivo;Infiltration;insight;Intake;interstitial cell;Ischemia;Logistics;Maintenance;mechanical signal;Mechanical Stimulation;mechanical stimulus;Mechanics;Metabolic;Methods;Nature;Operative Surgical Procedures;Outcome;Pathologic;Pathologic Processes;Pathology;Patients;Pattern;pediatric patients;Phenotype;Physiological;Physiology;preservation;prevent;professor;Protocols documentation;Rehabilitation therapy;repaired;Repeat Surgery;Research;Resources;Role;Sampling;skills;standard of care;stem cells;Stimulus;success;Surgeon;Techniques;Temperature;Testing;Time;Tissue Engineering;Tissue Preservation;Tissue Viability;Tissues;tool;Translational Research;Transplantation;Uncertainty;Universities;valve replacement;Ventricular

PROJECT_TITLE: Engineering a strategy for the preservation and rehabilitation of living allogenic heart valves


PHR: PROJECT NARRATIVE Hypertension is the leading risk factor for death and disability worldwide. The objective of this proposal is to determine the mechanisms by which CCR10, a receptor important for immune cell recruitment to the skin, promotes hypertension development. The proposed studies will test novel hypotheses related to the role of immune cells and the skin in hypertension development which will lay the foundation for development of new therapeutic targets and approaches.

PI_NAMEs: NGUYEN, BIANCA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Accounting;Adoptive Transfer;Adult;Albuminuria;angiogenesis;Angiotensin II;Apoptosis;Asthma;asthma model;Biological Assay;Blood;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;Blood Vessels;CD4 Positive T Lymphocytes;cell motility;Cell Physiology;Cell Proliferation;Cells;Cessation of life;chemokine receptor;Circulation;Coculture Techniques;Cutaneous;Cytometry;density;Development;disability;disability-adjusted life years;Endothelial Cells;Etiology;Exhibits;experimental study;Foundations;Future;Goals;GPR2 gene;Heart Diseases;Heart failure;Histologic;Homing;Hypertension;hypertensive;Immune;In Vitro;in vivo;Individual;Infiltration;Inflammation;Infusion procedures;Injury to Kidney;insight;Kidney;Laboratories;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Ischemia;neutralizing antibody;new therapeutic target;novel;Organ;Pathogenesis;Pathogenicity;Patients;Phenotype;Play;Population;Process;Production;Public Health;receptor;recruit;Regulatory T-Lymphocyte;Reporting;Resistance;response;Risk Factors;Rodent Model;Role;Signal Transduction;Skin;Smooth Muscle Myocytes;Sorting;Stroke;T cell infiltration;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Tube;Urine;Vascular Endothelial Growth Factors;Vascular resistance;Vascular Smooth Muscle;Vascularization;Vegf Inhibitor;VEGFA gene;years of life lost

PROJECT_TITLE: The Role of CCR10 and CCR10+ Tregs in Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE While presurgical (neoadjuvant) and the combination of pre and postsurgical (perioperative) immune-based therapy, such as treatment with immune checkpoint inhibitors (ICIs), has markedly improved survival outcomes of patients with early-stage non-small cell lung cancer (NSCLC), there are still many patients who show inferior response and ultimately succumb to the disease. A better understanding of mechanisms that underlie resistance to neoadjuvant/perioperative ICIs is a crucial prerequisite for personalizing immunotherapy, predicting therapeutic response, and even developing new immune-based therapies that confer robust survival advantages for a greater number of patients with early-stage NSCLC. This project will use multiple, unique and richly annotated human cohorts, state-of-the-art clinical trials, experimental mouse models that closely recapitulate pre and perioperative immunotherapy, as well as single-cell sequencing and spatial transcriptomics technologies to understand how B lineage cells, that remain much understudied compared to other lymphocytes (T cells), mediate response of early-stage NSCLC to neoadjuvant and perioperative immune-based therapy.

PI_NAMEs: CASCONE, TINA  (contact);KADARA, HUMAM

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Antitumor Response;arm;B-Cell Activation;B-Cell Development;B-Cell Neoplasm;B-cell receptor repertoire sequencing;B-Lymphocytes;biomarker validation;Blood specimen;Bypass;Cancer Patient;CD8B1 gene;Cell Communication;Cell Fraction;Cell Lineage;Cells;checkpoint therapy;chemotherapy;Clinical effectiveness;clinical practice;Clinical Trials;Clonal Expansion;cohort;Combined Modality Therapy;Coupled;cytotoxic;cytotoxic CD8 T cells;Disease;Distant;effective therapy;experience;Family;Frequencies;Genes;Genetic;Genetic Transcription;Goals;Human;Immune;Immune checkpoint inhibitor;immune modulating agents;Immuno-Chemotherapy;Immunogenomics;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In complete remission;Inferior;Infiltration;insight;Lead;Lung;Lymphocyte;Malignant neoplasm of lung;Maps;Mediating;Modeling;mouse model;multimodality;multiple omics;Mus;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;Nivolumab;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;organizational structure;Pathologic;patient population;Patient-Focused Outcomes;Patients;pembrolizumab;Perioperative;personalized immunotherapy;Phase;phase II trial;Phenotype;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;prevent;Primary Neoplasm;programmed cell death ligand 1;programs;Proteomics;Public Health;Randomized;Relapse;Reporting;Resectable;Resected;Resistance;response;Role;Sampling;single cell sequencing;single-cell RNA sequencing;standard of care;Structure of parenchyma of lung;survival outcome;T memory cell;T-Lymphocyte;Technology;tertiary lymphoid organ;Testing;therapy resistant;Tissues;transcriptomics;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;tumor-immune system interactions

PROJECT_TITLE: Dissecting the role of B lineage cells in mediating response of resectable lung cancer to neoadjuvant immune-based therapy

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Almost a third of the US population is exposed to unsafe ground ozone (O3) levels that negatively impact human respiratory and cardiovascular health through mechanisms that have not been entirely elucidated. The proposed work seeks to understand the role of O3-induced oxysterols on thrombosis by evaluating the hypercoagulability of plasma from O3 exposed subjects via thrombin generation and determining the effects of O3-induced oxysterols on endothelial cell activation. Together, data from this proposal will inform how O3 exposure and O3-induced oxysterols might impact cardiovascular disease by identifying specific biomarkers and mechanisms to clearly link oxidant air pollutant exposure with thrombotic risk.

PI_NAMEs: DOBSON, DREVON A (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Address;adduct;Affect;Air;Air Pollutants;Apoptosis;Biological;Biological Assay;Biological Markers;Blood Coagulation Factor;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cellular Stress;Cessation of life;Chemicals;Chemistry;Cholesterol;Clinical Research;comparison control;cycloaddition;cytokine;Data;differential expression;Electrical Resistance;Endothelial Cells;Endothelium;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Exposure to;Fibrinogen;Fibrinolysis;Functional disorder;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Health;Human;Human Volunteers;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;interest;Investigation;Knowledge;Link;Liver X Receptor;Lung;Lysine;Mass Spectrum Analysis;Mediating;Modeling;Oxidants;Ozone;ozone exposure;Participant;Pathway interactions;Persons;Phospholipids;Plasma;Plasma Cells;Plasmin;Population;Prevalence;protein function;Proteins;Proteomics;Public Health;Rattus;respiratory health;Respiratory System;Risk;Role;Sampling;specific biomarkers;Stress;Testing;Thrombin;Thrombophilia;Thrombosis;thrombotic;transcriptome sequencing;trend;tropospheric ozone;United States;Work

PROJECT_TITLE: The Effects of Ozone-Induced Oxysterols on Thrombotic Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Chronic low back pain (LBP) is costly and highly common worldwide, with limited effective treatment options. The proposed research will identify how social factors are involved in developing chronic LBP, including immune system involvement in the acute LBP stage. By identifying potential new groups of individuals or novel intervention pathways, this study could have far-reaching clinical impacts for preventing chronic LBP.

PI_NAMEs: BURKE, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Adult;Affect;African American;Anatomy;Anti-Inflammatory Agents;Area;Attenuated;Biological;Biological Factors;Biology;Biometry;Black American;Black race;Blood Cells;career;CD14 gene;Cells;Chronic;Chronic low back pain;chronic pain;Clinical;Communities;cost;Counseling;cytokine;Data;Dedications;Development;Dimensions;Disparity;Down-Regulation;effective therapy;Epidemiology;experience;Exposure to;FCGR3B gene;Frequencies;Funding;Goals;Health;health disparity;Healthcare;High Prevalence;high risk;Immune;Immune response;Immune system;immune system function;Immunobiology;Immunology;Immunotherapy;Incidence;Individual;Inflammatory;Inflammatory Response;innovation;insight;Institute of Medicine (U.S.);Interferon-beta;Interferons;Intervention;Knowledge;Low Back Pain;Measures;Mentorship;Minority Groups;Modeling;monocyte;Musculoskeletal Pain;novel;older adult;Outcome;Pain;pain chronification;Pain intensity;Pain interference;Pain management;pain outcome;pain score;Participant;Pathway interactions;Patient Self-Report;Patients;Phenotype;phenotypic biomarker;Plasma;Positioning Attribute;Prevalence;prevent;psychologic;Psychological Factors;Race;racial difference;racial disparity;racial identity;racial population;Reporting;Research;Research Personnel;Resources;Risk Factors;Role;Sampling;Severities;social;social engagement;social factors;social health determinants;Social isolation;Social status;Social stratification;sociodemographic factors;sociodemographics;Sociology;Subgroup;TNF gene;United States;United States National Institutes of Health;Up-Regulation;Work;years lived with disability

PROJECT_TITLE: Social Health Factors Associated with the Transition from Acute to Chronic Low Back Pain


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Little is known about the early impact of HIV on the heart, but new evidence suggests there are undetected abnormalities that may lead to more severe forms of disease if not adequately addressed. Studying individuals with HIV before and after initiation of lifelong antiretroviral treatment can enhance our understanding of how HIV damages the heart. This knowledge should lay the foundation for improvement in the prevention, monitoring, and treatment strategies in persons with HIV.

PI_NAMEs: ROBBERTSE, PIETER-PAUL STRAUSS (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Accreditation;Achievement;Address;advanced disease;Africa;Africa South of the Sahara;Age;antiretroviral therapy;Aorta;Area;arm;Award;biomarker validation;Biopsy;Cardiac;cardiac muscle disease;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;Certification;Chronic Disease;Clinical;clinical care;Clinical Research;cohort;Control Groups;Coronary Arteriosclerosis;coronary fibrosis;Country;cytokine;Data;Developing Countries;Development;Disease;Early Diagnosis;Early identification;Echocardiography;endothelial dysfunction;European;Evaluation;experience;Femur;Fibrosis;Fingerprint;Fostering;Foundations;Funding;Future;Goals;Health;Heart;Heart Atrium;heart damage;Heart Diseases;HIV;HIV Infections;Human Resources;Image;imaging biomarker;Imaging Techniques;improved;Income;Individual;Inflammation;Inflammatory;insight;Investigation;Knowledge;Literature;low and middle-income countries;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mentors;Modernization;Monitor;Morbidity - disease rate;Morphology;mortality;multimodality;multiparametric imaging;Myocardial;Myocardium;Newly Diagnosed;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Pericardial body location;Persons;Physiologic pulse;Population Group;Positioning Attribute;prevent;Prevention;Prevention strategy;Principal Investigator;Process;Prognosis;prospective;Published Comment;Publishing;Research;research study;Risk Factors;screening;Series;Serum;sex;South African;Structure;Sustainable Development;Techniques;Tissues;tool;Training;treatment strategy;United Nations;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Cardiovascular magnetic resonance assessment of subclinicalcardiovascular abnormalities before and after the initiation of antiretroviral therapy in HIV-infected South Africans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Over half of all autistic individuals demonstrate clinical levels of language impairment, including in vocabulary. Vocabulary skills correlate highly with vocational independence, mental health, and quality of life for autistic individuals – especially adults – and are the sole linguistic area to remain flexible across the lifespan. By studying how theory of mind difficulties in autistic individuals may be inhibiting vocabulary growth and determining the degree to which the underlying compensatory routes or alternative contexts may be leveraged in intervention, we will open the door to further linguistic interventions that can improve vocabulary – and thus language – outcomes even into adulthood and, through this, increase lifelong success.

PI_NAMEs: TRICE, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Age;age difference;Area;Association Learning;autism spectrum disorder;autistic;autistic children;Behavioral;Boston;Brain;Child;Clinical;Cognitive;cognitive process;Communication;community engaged research;Complex;Education;Face;fall risk;falls;Fellowship;flexibility;Functional Magnetic Resonance Imaging;Goals;Growth;hemodynamics;Image;improved;Individual;individuals with autism spectrum disorder;Inequality;inhibitor;Intervention;Joints;Language;Language Disorders;language impairment;language outcome;language processing;learned behavior;Learning;learning community;learning outcome;lens;lexical;Life;life span;Linguistics;Link;Magnetism;Maps;Measures;member;Memory;memory consolidation;Mental Health;Monitor;Nature;neural;Neurobiology;neuroimaging;Neurologic;neuromechanism;non-verbal;novel;Outcome;Participant;Pattern;peer;Personal Satisfaction;Persons;Play;Population;Quality of life;Reaction Time;Research;Resolution;response;Retrieval;Role;Route;School-Age Population;Semantics;skills;social;social cognition;stem;success;System;Techniques;theory of mind;Unemployment;United States;Universities;Vocabulary;Vocation;word learning;Work

PROJECT_TITLE: Vocabulary Encoding and Retention in Autism via Social Cognition (VERAS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Intellectual and Developmental Disabilities (IDD);Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Extracellular vesicles are cell-derived nanoparticles whose paracrine effects to neighboring cells are partly me- diated by their mitochondrial cargo. This project aims to (a) investigate mechanisms that may improve the quality of mitochondria in extracellular vesicles released by vascular endothelial cells, and (b) assess the therapeutic potential of horizontal mitochondrial transfer via extracellular vesicles, uniquely in the context of mitochondrial diseases. Completion of this project will fill in gaps in our understanding of endothelial cell dysfunction in mito- chondrial diseases, and provide the framework for a new research direction that may burgeon into a novel thera- peutic strategy for mitochondrial disease patients with vascular manifestations.

PI_NAMEs: MANZAR, ZAHID  (contact)

PROJECT_TERMS: Adult;Affect;Age Years;Antioxidants;Apoptosis;Base Pairing;Basic Science;Biological Assay;Biomedical Engineering;Blood;Blood specimen;Blood Vessels;brain endothelial cell;Cardiovascular Diseases;Cell Line;Cells;Characteristics;Child;Clinic;clinical practice;cytokine;Data;Defect;Development;Disease;DNA;effective therapy;Endosomes;Endothelial Cells;Endothelium;extracellular vesicles;Filtration;Flow Cytometry;Functional disorder;functional improvement;Gene Expression;genetic approach;Goals;Hereditary Disease;heteroplasmy;Human;human induced pluripotent stem cells;improved;In Vitro;Incubated;Induced Mutation;induced pluripotent stem cell;Inflammatory;inflammatory marker;Inherited;intercellular communication;Mediating;Medical Genetics;MELAS Syndrome;Membrane;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial Proteins;Modeling;Mutation;nanoparticle;Nitric Oxide;novel therapeutic intervention;Nuclear;Nucleic Acids;Oligomycins;Oxidative Stress;Oxygen Consumption;paracrine;Particle Size;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Physicians;Point Mutation;prevent;Production;Proteins;Proteomics;Protocols documentation;Reactive Oxygen Species;repaired;Reporting;Research;Resistance;Respiration;response;Role;Rotenone;Scientist;shear stress;Source;stem cell model;Stream;Stroke prevention;stroke therapy;stroke-like episode;Supervision;Symptoms;Syndrome;Testing;Therapeutic;TNF gene;Training;translational potential;Umbilical vein;Universities;Vascular Diseases;Vascular Endothelial Cell;vesicular release;Work

PROJECT_TITLE: Mitochondrial transfer via endothelial-derived extracellular vesicles as a potential therapy for vascular disease in MELAS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Opioid use disorder represents a major public health crisis with limited effective treatment options. This proposal seeks to determine how the interaction between the neuropeptide, galanin, and opioid receptors impacts opioid reward. Determining where and how galanin acts in the brain could identify novel therapeutic targets for opioid use disorder, offering insights into the neurobiological mechanisms and informing future interventions.

PI_NAMEs: PATE, BRITTANY SARA (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Ablation;addiction;Agonist;Attenuated;Behavior;Behavioral;Brain;Buprenorphine;career;Cell Nucleus;Cessation of life;Complex;conditional knockout;conditioned place preference;Coupled;Data;Death Rate;defined contribution;density;design;Development;Diagnosis;Disinhibition;Dopamine;dopaminergic neuron;Drug Addiction;Drug Metabolic Detoxication;Drug usage;Economic Burden;effective therapy;Elements;Endogenous Factors;Epidemic;Exhibits;experimental study;Family;FDA approved;Female;Fiber;Financial cost;Foundations;Future;G-Protein-Coupled Receptors;Galanin;galanin receptor;GALR1 Galanin Receptor;gamma-Aminobutyric Acid;Genetic;Goals;GTP-Binding Proteins;Health;Hypothalamic structure;Immunohistochemistry;In Situ Hybridization;Individual;Infusion procedures;insight;Intervention;Knockout Mice;Laboratory Finding;Lateral;Literature;LoxP-flanked allele;male;Mediating;Methadone;Mission;Molecular;Morphine;mu opioid receptors;Mus;Naltrexone;National Institute of Drug Abuse;Neuroanatomy;neurobiological mechanism;Neurobiology;Neurons;Neuropeptide Receptor;Neuropeptides;new therapeutic target;novel;novel therapeutics;Opioid;Opioid agonist;opioid epidemic;opioid overdose;Opioid Receptor;opioid use disorder;Outcome;Overdose;overdose death;overexpression;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Prevalence;prevent;programs;promoter;Public Health;Receptor Signaling;Research;response;reward circuitry;Rewards;Rodent;Role;Science;Scientist;side effect;Signal Transduction;Site;Societies;socioeconomics;Source;source localization;System;Testing;Therapeutic;therapeutic target;tool;Training;transmission process;treatment strategy;United States;Ventilatory Depression;Ventral Tegmental Area;Viral;Virus;Work

PROJECT_TITLE: Examining the modulatory role of galanin in opioid reward

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Familial dilated cardiomyopathy (DCM) is a genetic heart condition that leads to a weakened heart muscle and often requires a heart transplant, especially in young people. This project aims to develop a precise one-size- fits-all gene editing method that can correct the genetic errors underlying DCM to improve heart cell function. If successful, this approach has the potential to offer a single, one-time treatment for genetically diverse cases of DCM and potentially other genetic conditions.

PI_NAMEs: GASTON, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adrenergic beta-Antagonists;Affect;Affinity;Age;Arginine;autosomal dominant mutation;base;base editing;Bioinformatics;Biology;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiomegaly;Cardiomyopathies;Cell model;Cell Physiology;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;CRISPR/Cas technology;Defect;design;Development;Dilated Cardiomyopathy;Disease Progression;disease-causing mutation;DNA;DNA Damage;DNA Sequence;DNA-Directed DNA Polymerase;early onset;Endonuclease I;Environment;Exhibits;familial dilated cardiomyopathy;gene correction;Gene Expression;gene-editing approach;Genes;Genetic;Genetic Diseases;genome editing;Genomics;genotoxicity;Guide RNA;Heart;heart cell;Heart Diseases;Heart failure;heart function;Heart Transplantation;Heart Ventricle;Hereditary Disease;Impairment;improved;Individual;induced pluripotent stem cell;Inherited;Interferons;Lead;Measures;Mediating;Medical;Methods;Molecular;mouse model;Mutation;Myocardial Degeneration;Myocardium;Nucleotides;Other Genetics;Pathogenicity;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Point Mutation;postmitotic;Predisposition;prime editing;prime editor;Protein Binding Domain;Proteins;Quality of life;Regenerative capacity;Regulator Genes;Reporter;response;Retrotransposon;Risk;RNA Binding;RNA Recognition Motif;RNA Splicing;RNA-Directed DNA Polymerase;Sarcomeres;Serine;Signal Transduction;Site;Striated Muscles;sudden cardiac death;Symptoms;System;Testing;therapeutic genome editing;Time;Toxic effect;TP53 gene;Training;transcriptome;transcriptome sequencing;tripolyphosphate;Variant;Work;Writing

PROJECT_TITLE: A single prime editing strategy for correcting diverse mutations responsible for RBM20-associated dilated cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Defects in centromere integrity cause chromosomal mis-segregation and chromosomal instability, which are commonly observed in cancers. Under conditions of chronic oxidative stress (OS) cells exhibit increased centromeric aberrations; however, the effects of OS specifically at the centromere are unclear. In my proposal, I employ a specialized chemoptogenetic tool to target OS specifically at the centromere in order to investigate the DNA damage response and factors involved in maintaining centromere integrity.

PI_NAMEs: THOMPSON, LILY  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Affinity;Aftercare;Anaphase;Antioxidants;Apoptosis;Base Excision Repairs;Binding;cancer cell;carcinogenesis;Cell Cycle;Cell division;Cell Survival;Cells;cellular imaging;Cellular Stress;Centromere;centromere autoantigen 80K;Characteristics;Chromosomal Instability;Chromosomal Rearrangement;Chromosome Mapping;chromosome missegregation;Chromosome Segregation;Chromosomes;Chronic;Data;Defect;design;Disease;DNA;DNA biosynthesis;DNA Damage;DNA fiber assay;DNA Repair;DNA replication fork;Double Strand Break Repair;Dyes;Ensure;Exhibits;experimental study;Exposure to;Functional disorder;Genome;Genome Stability;Genomic Instability;homologous recombination;Immunofluorescence Microscopy;insight;Kinetochores;knock-down;Knowledge;Learning;Lesion;Light;live cell imaging;Maintenance;Malignant Neoplasms;Mediating;Metaphase Spread;Methods;Microscopy;Mitotic;Molecular;Mutation;Nature;Nerve Degeneration;OGG1 gene;Outcome;oxidative damage;Oxidative Stress;Oxidative Stress Induction;p53-binding protein 1;Pathogenesis;Pathology;Pathway interactions;Peptides;Photosensitizing Agents;Phototherapy;Predisposition;preservation;Production;protective factors;Proteins;Reaction;Reactive Oxygen Species;recombinational repair;recruit;repaired;replication stress;Research;response;Rest;Risk;segregation;Signal Transduction;Singlet Oxygen;Site;Stains;System;telomere;Testing;therapeutic target;tool;transcriptome sequencing;transcriptomics;XRCC1 gene

PROJECT_TITLE: Uncovering the impact of oxidative stress on centromere integrity


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Dedicated breast CT is a new imaging technique that does not require breast compression, provides fully 3D images, and can eliminate tissue superposition which could reduce unnecessary call-backs for additional imaging and could reduce missed cancers. Building on our prior work on the hardware design and engineering of the breast CT system, in this research, we focus on image reconstruction in breast CT to determine the optimal method, followed by a comparative study with digital breast tomosynthesis (also referred to as 3D mammography) to determine the benefits of dedicated breast CT for translating it to breast cancer screening.

PI_NAMEs: VEDANTHAM, SRINIVASAN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;appropriate dose;Benign;Biomedical Engineering;Biopsy;Breast;Breast Cancer Detection;breast density;breast imaging;Breast-Conserving Surgery;calcification;Callback;cancer imaging;Categories;Characteristics;Chest wall structure;Clinical;Clinical Data;clinical decision-making;clinical practice;clinical translation;Clinical Trials;cohort;Collaborations;Comparative Study;cone-beam computed tomography;Contrast Media;Data;Dedications;deep learning;design;detector;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Sensitivity;Diameter;Digital Breast Tomosynthesis;Digital Mammography;Discrimination;Disease;Dose;Eligibility Determination;Emerging Technologies;Engineering;Enhancing Lesion;Evaluation;Feasibility Studies;Funding;Future;Generations;Geometry;Goals;Image;image reconstruction;Imaging Device;imaging facilities;Imaging Techniques;improved;Industrialization;Information Systems;intravenous administration;Lesion;Low Dose Radiation;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Mathematics;Measurement;Measures;Methodology;Methods;Monitor;Multimodal Imaging;Neoadjuvant Therapy;Noise;Operative Surgical Procedures;Organ;Pectoralis Muscles;Performance;Physics;Pilot Projects;Population;predicting response;Progress Reports;prospective;prototype;quantitative imaging;Radiation Dose Unit;Radiology Specialty;Reader;Receiver Operating Characteristics;reconstruction;recruit;Regional Anatomy;Reporting;Research;Research Project Grants;Resolution;response;Risk Estimate;Scanning;Schedule;Science;screening;Screening procedure;self supervised learning;standard of care;State-of-the-Art Reviews;study characteristics;Subgroup;System;Techniques;Technology;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Tissue Sample;Tissues;tomography;training data;Translating;Translational Research;treatment planning;treatment response;tumor;Validation;Vendor;Visualization;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Towards screening with high-resolution, low-dose, dedicated breast CT

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Intimate partner violence (IPV), the most common form of violence worldwide, is responsible for a variety of physical and mental health problems for victims and exposed children that can persist throughout the life course. Despite increased awareness of the negative societal impacts of IPV and an international commitment to reducing IPV enshrined in the Sustainable Development Goals, numerous challenges exist in commonly used questionnaires to measure IPV. Improving the precision, validity, and cross-cultural consistency of IPV measurement is a prerequisite for accurately assessing the scope of the problem, evaluating efforts to prevent and reduce IPV, and effectively allocating resources to address this pervasive global health threat.

PI_NAMEs: BERGENFELD, IRINA  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: abuse neglect;Address;adolescent health;Age;Anxiety;Area;Attention;Awareness;Bayesian Modeling;career;Child;Child Health;combat;Communication;Consensus;Country;Data;Demographic and Health Surveys;Development;effectiveness evaluation;Effectiveness of Interventions;Equation;European Union;Evaluation;experience;Exposure to;Factor Analysis;Family;Federal Government;Fos-Related Antigens;Fright;Funding;global health;Goals;Health;healthy pregnancy;high risk;Home;improved;Income;Injury;International;intimate partner violence;Investigation;Knowledge;Life Cycle Stages;low and middle-income countries;Measurement;Measures;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Modeling;Monitor;National Institute of Child Health and Human Development;Outcome;Patient Self-Report;Performance;physical conditioning;Policy Analysis;population based;post-traumatic stress;Prevalence;prevent;prevention evaluation;programs;psychologic;psychological violence;Questionnaires;Recommendation;reproductive;Reproductive Health;Research Personnel;Resource Allocation;response;Rights;Robin bird;Sampling;sexual violence;skills;social stigma;Substance abuse problem;Surveys;Sustainable Development;Techniques;Testing;theories;Training;United Nations;United States National Institutes of Health;Violence;violence against women;violence prevention;Woman;Work;World Health Organization

PROJECT_TITLE: Improving Global Measurement of Intimate Partner Violence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is the most prevalent neurodegenerative disease and is characterized by amyloid beta (Aβ) accumulation, microtubule associated protein tau (MAPT, tau) aggregation, and synaptic deterioration. N6- methyladenosine (m6A)-modified RNA has been shown to increase in AD, interact with pathological Aβ and tau in AD, and regulate synaptic function; however, it is not well understood which m6A-modified RNAs interact with Aβ and tau and contribute to synaptic degradation in AD. Using a novel m6A sequencing approach, this proposal will elucidate the m6A-modified sites and transcripts in AD, distinguish the Aβ- and tau-driven m6A modification changes on RNA, and uncover the role of aberrant m6A RNA modifications in synaptic dysfunction, contributing fundamental knowledge toward a groundbreaking approach to therapeutically target AD pathophysiology.

PI_NAMEs: LIBERA, JENNA LYNN (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Address;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid beta-Protein;Antibodies;Automobile Driving;Autopsy;Bioinformatics;Biological Markers;Biology;Boston;Brain;brain tissue;case control;Cell Fractionation;cell type;Cognition;Communication;Complex;computational pipelines;Data;data integration;Data Set;Databases;Deamination;Dementia;Deterioration;differential expression;Disease;endophenotype;Environment;epitranscriptome;epitranscriptomics;Faculty;Fellowship;frontier;Functional disorder;gene-targeted therapy;Genes;Goals;Human;human model;Immunohistochemistry;Impaired cognition;Institution;International;Investigation;Knowledge;Laboratories;Learning;Link;Massachusetts;Memory;Methods;Methylation;Mission;Modification;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotransmission;new therapeutic target;novel;novel strategies;Nucleotides;Ontology;Pathologic;Pathology;Pilot Projects;Post-Transcriptional RNA Processing;Process;Proteins;Proteomics;Publications;Quantitative Trait Loci;Regulation;Reporting;Research Training;Resolution;response;Ribonucleoproteins;RNA;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Role;Sample Size;Sampling;scientific hub;Site;Site-Directed Mutagenesis;symposium;Synapses;synaptic function;Synaptosomes;tau aggregation;tau Proteins;Techniques;Technology;Testing;Therapeutic;therapeutic target;Training;Transcript;transcriptome sequencing;transcriptomics;translational applications;Translations;Universities;Validation;Western Blotting;Work

PROJECT_TITLE: Functional epitranscriptomic profiling of m6A RNA modifications in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  For a single cell to develop into a complex organism the genetic instructions encoded in the DNA need to be carefully regulated and properly expressed at the right time for achieving diverse functions necessary for proper development. This is in part regulated by the packaging of DNA into chromatin, where 146 base-pairs of DNA are wrapped around histone octamer proteins that conceal or reveal the necessary sequences for directing gene expression needs of the cell. My proposed research will address the kinetics and order of regulatory events at a model gene promoter for uncovering hidden steps in gene regulation relevant to all eukaryotes.

PI_NAMEs: YAMADI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affinity Chromatography;Animals;Architecture;ATP Hydrolysis;Back;Base Pairing;Binding;Binding Sites;Biogenesis;Biological Assay;Cell Extracts;Cell Nucleus;Cells;Cellular Structures;Chromatin;chromatin remodeling;Color;Complex;Data;design;Development;Disease;DNA;DNA Packaging;Elements;Embryonic Development;Enhancers;Enzymes;Eukaryota;Event;experimental study;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Histones;Image;In Vitro;Individual;insight;Instruction;ISWI;Joints;Kinetics;knock-down;Label;Life;Maintenance;Measures;Methods;model organism;Modeling;Movement;Nuclear Extract;Nucleosomes;Organism;Plants;Positioning Attribute;promoter;Promoter Regions;Proteins;reconstitution;recruit;Reporter;Reporting;Repression;Research;Resolution;RNA Polymerase II;Role;Saccharomyces cerevisiae;single molecule;single-molecule FRET;Slide;Speed;System;TAF1 gene;TATA Box;Testing;Thermodynamics;Time;Transcription Coactivator;transcription factor;Transcription Factor TFIID;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;Work;Yeasts

PROJECT_TITLE: Time-resolved chromatin accessibility by Single-Molecule FRET of +1 Nucleosome Dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because we will improve our understanding of sex-specific cardiac remodeling during myocardial fibrosis using bioengineered models of disease and identify paths toward sex-specific heart failure therapeutics. This project is relevant to the mission of the NIH, because heart failure impacts over six million people in the United States, and identifying sex-based heart failure therapeutics would help resolve gender health disparities in heart failure treatments.

PI_NAMEs: GORASHI, RAYYAN  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Affect;Animal Model;Anthracenes;Ants;Area;associated symptom;Automobile Driving;Biocompatible Materials;Biological Assay;Biology;Biomedical Engineering;Breeding;Cardiac;Cell Culture Techniques;Cells;Chromatin;Clinical;coronary fibrosis;crosslink;Deposition;Disease;disease model;dosage;Drug Targeting;EFRAC;Engineering;Epigenetic Process;epigenome;epigenomics;Estradiol;Estrogen Receptors;Estrogens;ethylene glycol;experience;Extracellular Matrix;Female;female sex hormone;Fibroblasts;Fibrosis;Four Core Genotypes;Gender;Genes;Genetic;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;health disparity;health inequalities;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;hormonal signals;Hormone Receptor;hormone regulation;Hormone use;Hormones;Hydrogels;improved;In Vitro;Individual;Infarction;inhibitor;Injury;knock-down;Laboratories;Lead;Left ventricular structure;Light;Link;male;mechanical signal;Mediating;Mediator;Methods;Mission;Modeling;Morbidity - disease rate;mouse model;Mus;Myocardial Infarction;Myocardium;Myofibroblast;Outcome;Ovariectomy;palliating symptoms;Pathologic;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Polymers;Population;Population Heterogeneity;preservation;Process;Proteins;Public Health;Quality of life;receptor expression;Regulation;Research;response;Role;sex;Sex Chromosomes;Sex Differences;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Swelling;Technology;Therapeutic;Thinness;Time;Tissues;tool;transcriptome;transcriptomics;Transposase;Treatment Failure;United States;United States National Institutes of Health;Ventricular;Ventricular Remodeling;Water;women patients;X Chromosome;X Inactivation

PROJECT_TITLE: Decoupling sex chromosome and sex hormone regulation of cardiac myofibroblast activation


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: PROJECT NARRATIVE The prescription opioid epidemic is a public health crisis with devastating consequences, including inadvertent overdose, spread of infectious disease, and neurocognitive impairments. Adolescents and young adults are uniquely vulnerable to substance use initiation given ongoing brain maturation. Discovering the neural mechanisms underlying neurocognitive impairments resulting from adolescent prescription opioid use disorder affords a critical opportunity to develop novel therapeutic targets; targets which may be unique under conditions of comorbid opiate abuse and HIV-1.

PI_NAMEs: MCLAURIN, KRISTEN ADDIE (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Age Years;Agonist;biological sex;biological systems;Biosensor;Brain;career;career development;Cells;Chronic;Clinical;cognitive process;Communicable Diseases;comorbidity;Control Animal;critical developmental period;Dependence;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Developmental Process;Dopamine;dopamine system;Dose;Environment;Episodic memory;Evaluation;experience;Experimental Designs;experimental study;exposure route;Exposure to;Faculty;Female;Fiber;Foundations;Functional disorder;G-Protein-Coupled Receptors;Gene Delivery;Goals;high risk population;HIV;HIV-1;Hour;Human;in vivo;Infection;Institution;Intake;International;Laboratories;male;Mentors;Modeling;Muscarinics;National Institute of Drug Abuse;Neurocognitive;Neurocognitive Deficit;neuromechanism;new therapeutic target;novel;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;opioid use disorder;Oral;Overdose;Oxycodone;oxycodone self-administration;Pharmacology;Phase;Photometry;postnatal;pre-clinical;Prefrontal Cortex;prescription opioid;Process;Public Health;Rattus;Research;Role;Saline;Scientist;skills;South Carolina;Strategic Planning;substance use;Substance Use Disorder;sustained attention;Synapses;System;Testing;therapeutic target;Training;United States Substance Abuse and Mental Health Services Administration;Universities;Ventral Tegmental Area;Viral Proteins;Water;young adult

PROJECT_TITLE: Neurocognitive Impairments Resulting from Adolescent Prescription Opioid Use Disorder: Longitudinal Impact, Neural Mechanisms, and Comorbidities


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Deficits persist following anterior cruciate ligament reconstruction surgery and are associated with poor outcomes at the time of return to sport. At the time of return to sports, athletes must be able to respond to environmental perturbation to safely participate in their sport. Studying the ability for athletes returning to sports after anterior cruciate ligament reconstruction to respond to environmental perturbations may uncover additional information regarding contributions to outcomes following anterior cruciate ligament injury and return to sports.

PI_NAMEs: KRONENBERG, JAMIE  (contact)

PROJECT_TERMS: Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Area;Athletic Injuries;Behavior;Biomechanics;Clinic;Clinical;clinical application;clinical care;Clinical Research;Complex;Computer software;data acquisition;Data Analyses;Data Collection;Dedications;Development;Elderly;Ensure;Environment;Environmental Risk Factor;Expert Systems;Faculty;falls;Fellowship;Foundations;Fracture;Future;Gait;Goals;Housing;improved;indexing;Individual;Injury;innovation;Institute of Medicine (U.S.);interest;Joints;kinematics;Knee;Knowledge;Laboratories;Leadership;Limb structure;Lower Extremity;Manuscripts;Measures;Mechanics;Mechanoreceptors;meetings;member;Mentorship;Methodology;Methods;Motor;Motor Activity;Movement;multidisciplinary;Muscle;Nature;novel;Ohio;Operative Surgical Procedures;Outcome;Patients;Pattern;Performance;Persons;physical therapist;Physical therapy;Physicians;Play;Population;Posture;preservation;prevent;Process;Productivity;Proprioception;Readiness;Reconstructive Surgical Procedures;Recurrence;rehabilitation research;Rehabilitation therapy;Research;research data dissemination;Research Design;research study;resilience;Resources;response;return to sport;Role;Science;Scientist;Series;skills;Sports;Sports Medicine;Students;Subgroup;success;Surgeon;System;theories;Time;Training;treatment strategy;United States;Universities

PROJECT_TITLE: Movement System Resiliency: Understanding Motor Responses to Mechanical Perturbation after ACLR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Intermediate care (i.e., step-down or progressive care) is prevalent in the United States, but the organization and scope of this level of care has changed over time with more severely ill patients needing services previously limited to the intensive care unit being admitted to intermediate care. There is growing concern that nursing workload in some models of intermediate care is excessive, which can lead to staff demoralization, burnout, and poor patient outcomes. In this proposal, we will use a mixed methods approach to (1) identify performance shaping features of intermediate care nursing work and (2) characterize the direction (amplify or decrease) and strength of association with perceived nursing workload.

PI_NAMEs: CASE, AARON SCOTT (contact)

PROGRAM_OFFICER_NAME: WYATT, DERRICK

PROJECT_TITLE: Performance Shaping Features of Intermediate Care Nursing Workload

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Despite advancements in management and treatment, atherosclero�c cardiovascular disease remains the leading cause of death worldwide. B lymphocytes are known regulators of atherosclerosis, and one subset known as Marginal Zone B cells produce protec�ve IgM an�bodies. This research proposal seeks to determine the molecular mechanisms by which transcrip�onal regulator ID3 modiﬁes the an�-inﬂammatory, protec�ve func�ons of marginal zone B cells, with the long-term goal of revealing novel risk-assessment strategies and poten�al therapeu�cs to reduce the prevalence of advanced cardiovascular disease.

PI_NAMEs: RANSEGNOLA, BRETT  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Alleles;alpha helix;Antibody Formation;Antibody titer measurement;ANXA5 gene;Aorta;Apoptosis;atheroprotective;Atherosclerosis;B cell differentiation;B Cell Proliferation;B-Lymphocyte Subsets;B-Lymphocytes;Bone Marrow;Cardiovascular Diseases;career;career development;Cause of Death;Cell Count;Cell Physiology;Cells;Cholesterol;Chronic;cohort;Collaborations;Coronary Arteriosclerosis;coronary computed tomography angiography;CRISPR/Cas technology;Data;design;Diet;Differentiation Inhibitor;Disease;Dyes;Environment;Epitopes;Event;Exposure to;Fellowship;Flow Cytometry;Fluorescein-5-isothiocyanate;Frequencies;Future;Genes;Genetic;Genetic Markers;Goals;Harvest;Heart;Helix-Turn-Helix Motifs;high dimensionality;Human;Immune;Immunoglobulin M;Immunohistochemistry;in vivo;Inflammation;Inflammatory;Institution;Knockout Mice;Lesion;Low-Density Lipoproteins;Lymphoid Tissue;Measures;Mentors;Mentorship;Molecular;mouse model;Mus;novel;Oils;oxidation;Patients;Physicians;Plasma;Prevalence;Production;Proliferating;Research;Research Proposals;Risk Assessment;risk variant;Role;Scientist;Severity of illness;Single Nucleotide Polymorphism;Sorting;Splenic Lymphoid Follicle;Stains;Surface;Testing;Training;training opportunity;Training Programs;transcription factor;transcriptome sequencing;translational physician;Translational Research;translational study;western diet;Work

PROJECT_TITLE: Molecular regulators of marginal zone B cells in atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Temporomandibular Muscle/Joint Disorder (TMJD);Transplantation

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  Temporomandibular joint (TMJ) replacement surgeries, used for patients suffering from a wide range of TMJ disc degenerative conditions, are restricted by unsuitable implant materials. While fresh TMJ donor allografts hold promise as a viable option, their potential remains largely unexplored due to limited availability and inefficient preservation methods. The goal of the proposed study is to overcome the current limitations of TMJ replacement surgeries by developing and optimizing an ice-free cryopreservation method to preserve cells, tissue structure, and biomechanical properties of TMJ disc allografts during long-term storage.

PI_NAMEs: MUELLER, DUSTIN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: absorption;Address;Affect;AlamarBlue;Allografting;American;Animals;articular cartilage;Autologous Transplantation;Biochemical;Biological;Biological Assay;Biomechanics;Blood Vessels;cartilaginous;Cell Death;Cell Survival;Cells;Clinical;clinical application;Computer Models;Cryopreservation;Cryoprotective Agents;Crystal Formation;cytotoxic;cytotoxicity;Data;Degenerative Disorder;Degenerative polyarthritis;Dermis;design;Development;Diffusion;Ensure;Exhibits;experience;Extracellular Matrix;Fascia;Fatty acid glycerol esters;Fellowship;Fibrocartilages;Fluorescence;Freezing;Fresh Tissue;Functional disorder;Future;Glass;Goals;Histologic;Hour;Ice;Image;Impairment;implant material;improved;improved outcome;intervertebral disk degeneration;Joints;Knee;Liquid substance;mechanical properties;Mechanics;Meniscus structure of joint;Metabolic;Methods;Morphology;Muscle;Operative Surgical Procedures;osteochondral tissue;Outcome;Patients;Penetration;preservation;Procedures;Property;Protocols documentation;Quality of life;Recovery;Refrigeration;Replacement Arthroplasty;Research;Sampling;Scientist;Site;Solid;Structure;Structure of articular disc of temporomandibular joint;Study models;Surface;Synovial joint;Techniques;Temporomandibular Joint;Temporomandibular Joint Disorders;Testing;Therapeutic;Time;Tissue Engineering;Tissues;Toxic effect;Training;Transplantation;Trauma;Work

PROJECT_TITLE: Optimizing Ice-free Cryopreservation for Efficient Banking of Fresh TMJ Disc Allografts

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Multiple system atrophy is an invariably fatal prion-like neurodegenerative disease caused by misfolding of the protein α-synuclein. Using unbiased transcriptomics to investigate the gain-of-function versus loss-of-function hypotheses underlying α-synuclein pathogenesis in disease, this project will determine the effect of protein misfolding on neuronal gene expression. The results from this proposal will lead to the identification of biomarker candidates for multiple system atrophy, which will drastically improve patient care and support better trial design.

PI_NAMEs: KHEDMATGOZAR, CHASE REZA (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Affect;alpha synuclein;Autonomic nervous system;Basal Ganglia;Behavioral;Biochemical;Biological Assay;Biological Markers;Biology;biomarker identification;Brain;Brain Stem;brain tissue;candidate marker;Cell Line;Cerebellum;Clinical;Clinical Trials;Cytoplasm;Cytoplasmic Granules;Data;Development;Diagnostic;diagnostic biomarker;differential expression;Disease;dopaminergic neuron;Enzyme-Linked Immunosorbent Assay;Exhibits;Freezing;Future;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Human;human induced pluripotent stem cells;human tissue;improved;Induced pluripotent stem cell derived human neuron;Kinetics;Knockout Mice;Knowledge;Light;loss of function;Measures;Membrane;Messenger RNA;mouse model;mRNA decapping;mRNA Decay;mRNA Stability;Multiple System Atrophy;Mus;Neurodegenerative Disorders;Neuroglia;Neurons;neurophysiology;novel marker;Parkinson Disease;Pathogenesis;Pathogenicity;Patient Care;patient stratification;Patients;Physiologic pulse;potential biomarker;prion-like;protein aggregation;protein expression;protein misfolding;Quantitative Reverse Transcriptase PCR;Recombinants;Research;response;RNA Decay;RNA Stability;Sampling;SNCA gene;specific biomarkers;synucleinopathy;Testing;Therapeutic;Time;Tissue Sample;transcriptome sequencing;transcriptomics;Transgenic Mice;transmission process;Treatment Efficacy;trial design;Validation;Western Blotting;Work

PROJECT_TITLE: A transcriptomics-based approach to identify quantitative biomarkers for multiple system atrophy


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Orphan Drug;Rare Diseases

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) causes respiratory failure, and patients frequently require life- support with mechanical ventilation when affected with ARDS. Mechanical ventilation can be lifesaving but can also cause an injury known as ventilator induced lung injury (VILI), which is at least partly due to surfactant dysfunction. This proposal will deepen our understanding of the mechanisms that drive surfactant dysfunction in VILI and identify novel therapeutic targets to improve the outcomes of patients with ARDS who require mechanical ventilation.

PI_NAMEs: BENTLEY, IAN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Actins;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Alveolar;alveolar lamellar body;Alveolus;Annexins;atelectrauma;Award;Bacterial Pneumonia;Binding;Binding Proteins;Bundling;career;career development;Cell Culture Techniques;Cell membrane;Cell Separation;cell type;Cell-Free System;Cells;Clinical;COVID-19 pandemic;Critical Illness;cytokine;Data;Death Rate;Devices;Dysbarism;Educational workshop;Epithelial Cells;fabrication;Foundations;Functional disorder;Gene Modified;Generations;Goals;Grant;Human;Impairment;improved outcome;Inflammatory;inhibitor;Injury;Lead;Life;Lung;lung injury;Manuscripts;Measures;Mechanical ventilation;Mediating;Mentorship;Modeling;Molecular;Molecular Target;molecular targeted therapies;mouse model;Mus;mutant;N-terminal;new therapeutic target;novel;Organelles;Outcome Assessment;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Permeability;Persons;pharmacologic;Phospholipids;Phosphorylation;Phosphotransferases;Physicians;Physiology;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;Predisposition;Preparation;prevent;Principal Investigator;Production;Property;Protein Biosynthesis;Protein Secretion;protein-tyrosine kinase c-src;Proteins;Publications;pulmonary function;Pulmonary Surfactants;Research;Research Personnel;Respiratory Failure;Role;Scientist;Series;Site;skills;src-Family Kinases;Stress;Stretching;Structure;Surface Tension;surfactant;surfactant function;symposium;therapeutic target;Time;Training;Training Support;Tyrosine;United States National Institutes of Health;Ventilator;Ventilator-induced lung injury;Volutrauma;Work;Writing

PROJECT_TITLE: Post-Translational Modification of Annexin A2 Mediates Surfactant Dysfunction During Injurious Mechanical Ventilation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE The risk of developing cerebrovascular diseases, Alzheimer’s disease and related dementias increases with advancing age, largely due to declines in cerebral blood vessel function, which is influenced by age-related increases in mitochondrial oxidative stress. As the aging population is projected to increase in the coming years, establishing effective strategies to improve cerebrovascular function in older adults by decreasing mitochondrial oxidative stress is an urgent biomedical research priority. This project will investigate the efficacy of a new therapeutic intervention - mitochondrial-targeted antioxidant supplementation, MitoQ - for improving cerebral blood vessel function, assess the possible mechanism(s) contributing to these benefits and determine whether MitoQ improves cognitive function in older adults.

PI_NAMEs: DARVISH, SANNA  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acetylcholine;Acute;Address;Aftercare;age effect;age related;Age Years;age-related disease;Aging;aging population;Alzheimer's disease related dementia;Antioxidants;Area;Biochemical;Biological;Biological Availability;Biomedical Research;Blood Flow Velocity;Blood Vessels;brachial artery;brain endothelial cell;Cardiovascular Diseases;cardiovascular risk factor;Cause of Death;Cell Physiology;Cerebral endothelium;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Chronic;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive function;cognitive performance;Colorado;Crossover Design;Data;Dementia;Development;disorder risk;doctoral student;Dose;Double-Blind Method;effective intervention;efficacy evaluation;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;executive function;Exposure to;Fellowship;Functional disorder;Funding;graduate student;Human;Hypercapnia;Impaired cognition;Impairment;improved;in vivo;Infrastructure;innovation;insight;Internal carotid artery structure;Investigation;Laboratories;Learning;Liquid substance;Measurement;Measures;Mediating;Mentors;Mitochondria;Mitochondrial Matrix;mortality;National Research Service Awards;Nitric Oxide;novel strategies;novel therapeutic intervention;old mice;older adult;older men;older women;Oral;Outcome;Oxidative Stress;Parents;Peripheral;Placebo Control;Placebos;Plasma;Positioning Attribute;prevent;processing speed;Production;Randomized;Reactive Oxygen Species;Research;Research Personnel;Research Priority;Research Project Grants;response;Rest;Risk;Risk Factors;seal;skills;Supervision;Supplementation;System;Trail Making Test;Training;Translating;translational approach;treatment duration;United States National Institutes of Health;Universities;vascular endothelial dysfunction

PROJECT_TITLE: Chronic MitoQ Supplementation for Improving Cerebrovascular Function in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]