NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: MALDONADO, YVONNE A. (contact)

PROJECT_TERMS: Academia;Advisory Committees;Aging;American;Area;Attitude;Award;Behavioral;Big Data;biobehavior;Biological;biomedical data science;career;career development;Career Mobility;career networking;Centers for Population Health;Clinical Research;Clinical Sciences;Collaborations;community organizations;Data;Data Set;Databases;design;Development;Development Plans;digital health;early-career faculty;education research;Educational process of instructing;Environment;Equity;equity, diversity, and inclusion;Faculty;faculty research;Feedback;Fellowship;Funding;Future;Goals;Government;Grant;Growth;Health Disparities Research;health disparity;health equity promotion;Health Sciences;Healthcare;Healthcare Systems;implementation science;Industry;innovation;Institution;Instruction;Intervention;Justice;Knowledge;Lead;Leadership;leadership development;Learning;Longevity;Manuscripts;medical schools;member;Mentors;Methodology;Methods;Minority-Serving Institution;Names;novel strategies;Paper;peer;Peer Review;Pilot Projects;podcast;Population;Positioning Attribute;precision medicine;Productivity;professor;programs;Psychiatry;Publications;Publishing Peer Reviews;Qualitative Methods;Qualitative Research;recruit;Registered nurse;Reproducibility;Research;Research Ethics;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Research Training;Resources;Role;Schools;Science;Scientist;Secure;Series;simulation;Site;skills;social;social culture;success;symposium;Teacher Professional Development;Techniques;Time;Training;Underrepresented Populations;United States National Institutes of Health;Universities;virtual reality;virtual reality simulation;Writing

PROJECT_TITLE: Longevity, Equity, and Aging Research Network (L.E.A.R.N.) Consortium Research Education Core


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neurodevelopmental disorders affect ~3-18% of children worldwide and are heavily biased towards males early in life. Growing evidence suggests that early-life experiences, such as infection during the perinatal period, can have a profound, life-long impact on brain development and behavior. In this proposal, we will examine how sex differences in brain development increase male vulnerability to such early-life immune perturbations, with promise to provide novel therapeutic targets and preventative interventions for these children.

PI_NAMEs: BORDT, EVAN ANDREW (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Ablation;Affect;Androgen Receptor;Androgens;Anterior;anxiety-like behavior;Autopsy;Behavior;behavior change;Behavioral;behavioral outcome;Bioenergetics;Birth;Brain;brain cell;Brain region;Cells;Child;cingulate cortex;Cognitive;Communication;critical period;Data;Development;differential expression;disorder risk;early onset;Electron Transport;Endotoxins;ESR1 gene;Estradiol;Estrogen Receptors;Estrogens;Etiology;Exposure to;Female;fly;Functional disorder;Gene Expression;gene repression;Genes;Gonadal Hormones;GPER gene;Hormones;Immune;Impaired cognition;Incidence;Individual;Infection;Inflammatory;Injections;Knowledge;Life;Life Experience;Link;Lipopolysaccharides;male;Masculine;Mediating;Microglia;Mitochondria;mitochondrial metabolism;Modeling;Morphology;mouse model;Mus;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;new therapeutic target;Pathway interactions;patient subsets;Perinatal;perinatal brain;perinatal period;Phagocytosis;Phenotype;Play;Predisposition;preventive intervention;Process;programs;Proteins;pup;receptor;Receptor Signaling;Regulation;Reporting;response;Role;sex;Sex Bias;Sex Differences;Signal Transduction;social;Social Behavior;social bias;Stimulus;Symptoms;Synapses;Testing;Testosterone;women subjects;Work

PROJECT_TITLE: Perinatal Gonadal Hormones Impart Male-Biased Neuroimmune, Mitochondrial, and Behavioral Vulnerabilities.

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PHR: public health relevance. The current proposal will bring together two laboratories with expertise in neuroimaging and ME/CFS research to improve our understanding of the neural underpinnings of cognitive control deficits in patients with ME/CFS and PASC-ME/CFS. Through a multimodal study combining behavioral, EEG, fMRI and neuroimmune analyses, we will identify the oscillatory, connectomic and inflammatory markers of impaired cognitive control in ME/CFS and PASC-ME/CFS. Our specific aims are to: 1) define the oscillatory markers of cognitive deficits in patients, 2) define the deficits in task-induced reconfiguration in the cognitive control network in patients, 3) determine the relationships among the inflammatory, electrophysiologic, and connectomic markers of impaired cognitive control in ME/CFS and PASC-ME/CFS. Our proposal will lay the groundwork for development of novel therapies that can target the spatiotemporal neuromarkers identified in our studies to mitigate cognitive deficits in individuals with ME/CFS and PASC-ME/CFS.

PI_NAMEs: ERYILMAZ, H HAMDI (contact);VANELZAKKER, MICHAEL B

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;American;Anterior;Attention;Autonomic Dysfunction;biomarker identification;Brain;brain fog;Brain imaging;burden of illness;Chronic Fatigue Syndrome;cingulate cortex;Clinical Trials;Cognition;cognitive control;Cognitive deficits;comparison control;Conflict (Psychology);cost;COVID-19;COVID-19 pandemic;COVID-19 patient;cytokine;Data;Diagnosis;diagnostic criteria;Dorsal;effective intervention;Electroencephalography;Electrophysiology (science);Exertion;Exhibits;experience;Exposure to;Fatigue;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Immunologics;Impaired cognition;Impairment;improved;Individual;Infection;Inflammation;inflammatory marker;Long COVID;Malaise;Measures;Memory;Methods;multimodality;Neurobehavioral Manifestations;Neurocognitive Deficit;neuroimaging;neuromechanism;neurophysiology;neuropsychiatry;novel;Pain;pathogen;Patients;Pattern;Performance;Peripheral;persistent symptom;Pilot Projects;Post-Acute Sequelae of SARS-CoV-2 Infection;predictive modeling;Psychoses;Qualifying;Reaction Time;Rehabilitation therapy;Reporting;Research;SARS-CoV-2 infection;Short-Term Memory;Source;Symptoms;targeted biomarker;targeted treatment;temporal measurement;therapy development;Time;tool;Virus Diseases;Work

PROJECT_TITLE: Mechanisms of Cognitive Control Impairment in ME/CFS and PASC-ME/CFS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-K(80)S]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biomedical Imaging;Lung;Precision Medicine;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  An aberrant immune response to injury is a crucial pathogenic driver of acute lung injury (clinically known as acute respiratory distress syndrome) and fibrotic lung diseases. However, there is currently no clinical technique for non-invasive assessment of lung inflammation, which has challenged the development of a precision medicine approach to acute respiratory distress syndrome and fibrotic lung diseases. This proposal is aimed to validate the role of targeted imaging of chemokine like receptor-1 (CMKLR1, a relatively recently discovered chemokine receptor contributing to leukocyte recruitment) for quantitative monitoring of lung inflammation, risk stratification of the disease, and monitoring the therapeutic response in experimental models of acute lung injury and fibrotic lung diseases.

PI_NAMEs: TAVAKOLI, SINA  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adverse effects;Anti-Inflammatory Agents;Biological;Biological Assay;Biological Markers;Bleomycin;Categories;chemokine receptor;cigarette smoke-induced;Clinical;clinical translation;clinically relevant;CMKLR1 gene;cost;COVID-19;COVID-19 patient;Data;Development;Dexamethasone;diagnostic strategy;Diesel Exhaust;Disease;Disease Outcome;disease prognosis;Disease Progression;Disease stratification;disorder risk;Early Diagnosis;Experimental Models;Extracellular Matrix;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;fibrotic lung disease;Flow Cytometry;Future;Goals;Heterogeneity;Histologic;Histology;Image;Immune response;improved;Inflammation;Inflammatory;inflammatory lung disease;Injury;Interstitial Lung Diseases;Intervention;Label;Leukocytes;Ligands;Lipopolysaccharides;Lung;Lung Diseases;lung injury;Macrophage;Mediating;molecular imaging;Molecular Target;Monitor;monocyte;mortality risk;mouse model;novel;novel marker;Occupational;Organ;overexpression;particle;Pathogenesis;Pathogenicity;Pathologic Processes;patient stratification;Patients;peptidomimetics;personalized management;personalized medicine;Pirfenidone;Plasma;Play;Positron-Emission Tomography;precision medicine;Process;prognostication;progression risk;prospective;Pulmonary Fibrosis;Pulmonary function tests;Pulmonary Inflammation;quantitative imaging;radiotracer;recruit;response;response to injury;risk prediction;risk stratification;Role;Sarcoidosis;Severities;Severity of illness;spatiotemporal;Specimen;targeted imaging;Techniques;Tissues;tool;Tracer;treatment response;uptake;Validation;Viral Pneumonia;X-Ray Computed Tomography

PROJECT_TITLE: CMKLR1-Targeted Molecular Imaging of Inflammation as a Precision Medicine Tool in Acute Lung Injury and Fibrotic Lung Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) is the deadliest and most difficult-to-treat subtype of lung cancer with a standard-of-care that has remained largely unchanged for decades. Arginine deprivation by pegylated arginine deiminase (ADI-PEG20) is the most effective targeted therapy in preclinical studies of MYC-driven SCLC, but tumors eventually become resistant to ADI-PEG20. In accordance with NIH’s mission to advance human health, this study will interrogate mechanisms of ADI-PEG20 resistance to identify therapeutic strategies that prolong the efficacy of ADI-PEG20 and improve survival of patients with SCLC.

PI_NAMEs: IRELAND, ABBIE SHAYE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: activating transcription factor;activating transcription factor 4;Acute;Anabolism;Arginine;Arginine deiminase;argininosuccinate synthase;ASCL1 gene;Aspartate;base editing;BETA2 protein;Cancer Biology;Cancer Model;cancer subtypes;Carbon;chemotherapy;ChIP-seq;chromatin immunoprecipitation;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Computer Analysis;Consumption;Data;Data Analyses;Data Set;Dependence;deprivation;desensitization;Development;Disease;disease model;effective therapy;Environment;Enzymes;experimental study;Family member;Folic Acid Antagonists;gene synthesis;Genes;Genetic Transcription;Genetically Engineered Mouse;Glean;Goals;Health;Human;human model;Huntsman Cancer Institute at the University of Utah;improved;In Vitro;in vivo;inhibitor;Isotopes;Knowledge;lung cancer cell;Lung Neuroendocrine Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Mission;Modeling;molecular subtypes;mouse model;MYCL1 gene;MYCN gene;Neoplasm Metastasis;Neuroendocrine Tumors;novel;Nucleotide Biosynthesis;nucleotide metabolism;Oncogenic;overexpression;Patients;Pharmaceutical Preparations;Physiological;Platinum;Play;preclinical study;preclinical trial;prevent;Process;programs;rapid growth;Regulator Genes;Research;Resistance;Resistance development;resistance mechanism;Resources;response;Role;Secondary to;Serine;single-cell RNA sequencing;small cell lung carcinoma;Specific qualifier value;standard of care;Starvation;Stress;System;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;Time;Training;transcription factor;transcriptomics;treatment strategy;tumor;tumor metabolism;United States National Institutes of Health;urea cycle

PROJECT_TITLE: Investigating and targeting metabolic vulnerabilities of MYC-driven small cell lung cancer


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Macrophages are key orchestrators of inflammatory responses in the lung, and they are important contributors to ARDS and ARDS resolution. MEK1 and MEK2 are protein kinases that regulate important cellular functions, and our data implicate MEK pathways as key factors directing macrophage polarization and ALI duration. This proposal will uncover a novel pathway by which inflammatory diseases in the lung may be modified.

PI_NAMEs: MANICONE, ANNE M. (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acceleration;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Alveolar Macrophages;Antibodies;Automobile Driving;Binding;Biological;Body Weight;Cell Physiology;Cell Survival;Cells;Cessation of life;Clinical;Data;Dependence;Disease;Dose;Enterobacteria phage P1 Cre recombinase;epithelial repair;experience;extracellular;Extracellular Signal Regulated Kinases;Gene Expression;Gene Expression Profile;Genetic Polymorphism;Human;IFNAR1 gene;Immune system;Impairment;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;injury recovery;Interferon Type I;Interleukin-4;KRP protein;Leukocytes;Lung;lung injury;Macrophage;Macrophage Activation;MAP2K1 gene;MAPK3 gene;Measures;MEKs;Mitogen-Activated Protein Kinases;Modeling;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Neutrophil Infiltration;Neutrophilia;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;pre-clinical;Process;Protein Isoforms;Protein Kinase;Publishing;Pulmonary Inflammation;Recovery;Regulation;Regulatory Pathway;repaired;Resolution;response;Rodent;Role;Route;SARS-CoV-2 infection;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Source;Sterility;Testing;Therapeutic;Time;Toxic effect;Translating;Wild Type Mouse;Work;wound healing

PROJECT_TITLE: MAP2K1 AND MAP2K2 IN ACUTE LUNG INJURY AND RESOLUTION

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

PHR: Project Narrative This project will employ pupillometry to examine the function of the melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) that are critical for the normal function of the circadian system. The experiments will provide novel insights into mechanisms of circadian dysregulation across the continuum of PD and the contribution of circadian dysregulation to poor sleep and sleepiness, common and disabling symptoms associated with PD. Results from this study will further explore the eye (retina) and the circadian system as novel therapeutic targets in PD and guide the development of circadian-based treatments to improve the daily lives of patients with PD.

PI_NAMEs: VIDENOVIC, ALEKSANDAR  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acceleration;actigraphy;Admission activity;Advanced Development;advanced disease;Affect;Age;Anatomy;Area;associated symptom;Attenuated;Binding;Biological Markers;Biological Rhythm;Blood specimen;Brain;Cell Physiology;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;clinical implementation;Clinical Research;common symptom;Companions;Consensus;constriction;Corpus striatum structure;Denervation;density;Development;diaries;disabling symptom;Disease;Dopa;dopamine transporter;Drowsiness;effective therapy;Etiology;experimental study;Eye;follow-up;Foundations;Functional disorder;functional improvement;Gender;Gene Expression;gene therapy;Genes;Goals;Health;Hour;Human;Hypothalamic structure;Image;Impairment;improved;Individual;Inpatients;insight;Intervention;Investigation;Light;light effects;light transmission;Lighting;Measurement;Measures;meetings;melanopsin;Melatonin;Modeling;Monitor;Morphology;National Institute of Neurological Disorders and Stroke;Nature;neurophysiology;new therapeutic target;non-motor symptom;novel;novel marker;Parkinson Disease;Participant;participant enrollment;Pathogenesis;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;Photoreceptors;Phototherapy;Phototransduction;Physiology;Pittsburgh Sleep Quality Index;Play;Polysomnography;poor sleep;Positioning Attribute;Protocols documentation;Pupil;Questionnaires;REM Sleep Behavior Disorder;Reporting;Research;Resistance;response;Retina;Retinal Degeneration;Retinal Ganglion Cells;Role;screening;single photon emission computed tomography;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep quality;Sleep Wake Cycle;Stimulus;suprachiasmatic nucleus;Surrogate Markers;Symptoms;synucleinopathy;System;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: Retinal Determinants of Circadian Function and Sleep-Wake Cycles in Parkinson's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Fundamental questions for HIV cure research are: how does the size of viral reservoirs impact people with HIV's ability to prevent viral rebound or control virus replication after stopping antiretroviral therapy (ART)? In this study, we use a unique monkey model to determine how progressively smaller viral reservoirs affect the durable control virus replication after discontinuing ART.

PI_NAMEs: REYNOLDS, MATTHEW R. (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Address;Affect;Aftercare;antiretroviral therapy;antiviral immunity;Autologous;Bar Codes;CD4 Positive T Lymphocytes;Cells;Clinical Trials;clinically relevant;Communities;curative treatments;Cytotoxic T-Lymphocytes;Disease remission;Event;Goals;HIV;Human;Immune response;Immunologics;In Vitro;in vivo;Interruption;Intervention;Length;Macaca mulatta;mathematical model;Modeling;Monkeys;novel;novel strategies;Patients;Persons;Plasma;predictive marker;predictive modeling;prevent;Recombinants;Regimen;Research;Research Priority;Rhadinovirus;SIV;Slide;Testing;therapy development;Time;tool;United States National Institutes of Health;Viral;Viral Load result;viral rebound;Viral reservoir;Viremia;Virus Latency;Virus Replication

PROJECT_TITLE: Determining the impact of ultra-small SIV reservoirs on sustained ART-free remission

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Primary Health Care

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Lung cancer screening efficacy is highly dependent on adherence to recommended guidelines, with annual screening indicated for approximately 90% of all individuals who receive baseline scans. Initial reports of real- world screening implementation show adherence to annual screening guidelines are less than 50%, demonstrating a critical need for improvement to optimize the individual and population health benefits of lung cancer screening. I aim to address the urgent need for low-cost, feasible, and effective interventions focused on facilitating lung cancer screening adherence by developing and implementing a set of clear and engaging reminder messages that target and tailor information specific to lung cancer screening participants.

PI_NAMEs: HIRSCH, ERIN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Algorithms;Benefits and Risks;Breast Cancer Detection;cancer diagnosis;Cancer Etiology;career;Cervical Cancer Screening;Cessation of life;Characteristics;Clinical;Clinical Trials;clinically significant;Cognitive;colorectal cancer screening;computed tomography screening;Computerized Medical Record;Consumption;cost;Counseling;Data;Dedications;design;Development;Diagnosis;dissemination science;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Eligibility Determination;evidence base;experience;Exposure to;former smoker;Goals;Guideline Adherence;Guidelines;Health;health application;Health behavior;Health Benefit;high risk;high risk population;Human Resources;Hybrids;Image;implementation outcomes;implementation research;implementation science;improved;Individual;informant;information processing;innovation;Intervention;intervention program;Intervention Studies;Interview;low dose computed tomography;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;Mentors;Methods;mortality;Outcome;Outcome Measure;Parents;Participant;patient engagement;Patients;person centered;Phase;population based;population health;Postdoctoral Fellow;pragmatic study;primary care provider;Process;programs;protective behavior;Provider;Recommendation;Reminder Systems;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;risk perception;routine screening;Scanning;Scientist;screening;Screening for cancer;screening guidelines;screening program;shared decision making;skills;Smoker;Smoking;social;social health determinants;social stigma;Specialist;Surveys;System;Testing;theories;therapy development;Time;tool;Training;Training Programs;user centered design;Visit

PROJECT_TITLE: Optimizing adherence to lung cancer screening: Applying theory and implementation science to participant engagement


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences;Sleep Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative  We develop a cell-based system that is as good as live animal models in evaluating any mutation in major clock genes, which used to be done in live animals. Many human mutations will be precisely evaluated by the system for their pathogenesis and the results will inform affected humans with pathogenic mutations in clock genes identified by the study.

PI_NAMEs: LEE, CHOOGON  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;Affect;Animal Model;Animals;ARNTL gene;Awareness;beta-Transducin Repeat-Containing Proteins;Biochemical;Biological Assay;Bioluminescence;Biotin;Calibration;Cell Line;Cell model;Cell Physiology;Cells;circadian;circadian pacemaker;Circadian Rhythms;Clinical;Clock protein;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complex;cost effective;CSNK1A1 gene;Data;Disease;dosage;Ensure;Environment;enzyme activity;Functional disorder;Gene Mutation;Genes;Genetic;Genetic Transcription;genome editing;Goals;Human;Human Cell Line;human disease;In Vitro;in vivo;in vivo Model;individualized medicine;insight;Jet Lag Syndrome;Knock-in;Knock-out;Knockout Mice;Mediating;Melatonin;Mus;mutant;Mutation;novel;Pacemakers;Pathogenesis;Pathogenicity;Pathologic;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phototherapy;Physiology;programs;promoter;Property;Proteins;reconstitution;Reporter;Reporting;Resources;reverse genetics;Single Nucleotide Polymorphism;Site;Sleep;Sleep Disorders;Sleep Wake Cycle;Speed;Streptavidin;Structural Biologist;structural biology;Study models;System;tau mutation;tau Proteins;Techniques;Testing;Tetanus Helper Peptide;Thalidomide;Time;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: A novel cell-based platform to study human circadian disorders

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Many studies have shown that the progression of varies substantially from patient to patient. It is important to identify subpopulations who may benefit from the investigational treatment. Subgroup identification can help clinicians select patients who are most likely to have a positive response to a treatment. It may also inform the development of new therapeutic agents that can improve the treatment of AD. In this proposal, we will use the tree-based and the regression-based methods to select responsive subgroups and characterize individual heterogeneity. Our methods will be illustrated using large amounts of individual level clinical trial data for investigational drugs including donepezil, solanezumab, and gantenerumab.

PI_NAMEs: LIU, LEI  (contact);WANG, GUOQIAO

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Address;Aducanumab;Affect;Aging;Alzheimer's Disease;American;analytical method;analytical tool;Area;Behavioral;Biological;Cause of Death;Characteristics;Clinical Data;Clinical Trials;Cognitive;Collaborations;Communities;Computer software;Country;Data;data mining;Dementia;design;Development;Disease;Disease Progression;donepezil;evidence base;flexibility;Future;Goals;Grouping;Health;Healthcare;improved;Individual;individual variation;individualized medicine;innovation;interest;Investigational Drugs;Investigational Therapies;Knowledge;Machine Learning;Measures;Methodology;Methods;Modeling;novel;novel therapeutics;Outcome;Patient Selection;Patients;payment;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Population Heterogeneity;precision medicine;prevent;primary outcome;prospective;Public Health;Reporting;Research;Research Personnel;response;Selection for Treatments;Subgroup;Therapeutic Agents;tool;treatment effect;Treatment outcome;treatment research;treatment response;treatment trial;Trees;user-friendly

PROJECT_TITLE: Innovative precision medicine methods in subgroup identification for Alzheimer's disease

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Emphysema;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Emphysema is one of the leading causes of morbidity and mortality worldwide, and there are currently no treatments available to reverse the resulting lung damage. This study aims to find new biomarkers that can predict the early onset of emphysema, distinguish between its diverse pathologic patterns and their regional distributions, and provide insights into the underlying pathobiology. A better understanding of emphysema and its subtypes will aid in the development of novel and personalized therapies to improve the health of millions of affected individuals.

PI_NAMEs: EL BOUEIZ, ADEL  (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Address;Affect;airway epithelium;Algorithms;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;alveolar destruction;Area;attenuation;Benchmarking;Biological;Biological Markers;Biology;biomarker identification;Blood;Blood specimen;chest computed tomography;Chronic Obstructive Pulmonary Disease;Clinical;clinical predictors;Cluster Analysis;cohort;Data;Data Analyses;data modalities;deep neural network;Development;Diagnosis;Disease;disorder subtype;DNA Methylation;early onset;Epithelial Cells;Equilibrium;explainable machine learning;feature selection;Fibroblasts;Functional impairment;Funding;Gene Expression;Gene Silencing;Generations;Genes;genetic variant;genome sequencing;Graph;graph neural network;Health;Image;Imaging Techniques;improved;In Vitro;Individual;innovation;insight;Investigation;Knowledge;Length;Lobar;Lung;lung injury;lung lobe;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Measurement;Measures;Methodology;Methods;Modeling;Modernization;Molecular;molecular subtypes;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;novel therapeutics;overexpression;Pathologic;Pathway Analysis;Pathway interactions;Pattern;Performance;peripheral blood;personalized medicine;personalized therapeutic;Phenotype;predictive marker;predictive modeling;Process;Prognosis;Proteomics;Pulmonary Emphysema;Radiation exposure;Reporting;Reproducibility;Research;Resources;Scanning;Severities;Smoker;Structure of parenchyma of lung;Subgroup;support vector machine;Systems Biology;telomere;Testing;Tissue Sample;transcriptome sequencing;Validation;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Imaging and multi-omics analyses to identify molecular subtypes of distinct emphysema patterns

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: DETROIT

ORG_DEPT: PSYCHIATRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE The proper function of adipose tissue is essential for metabolic health and depends on close interactions of diverse cell types in the tissue microenvironment. This project will examine how close (micrometer-scale) cellular interactions in adipose tissue regulate the establishment, expansion, and pathophysiological remodeling fat tissues. This analysis will provide new insights into how fat tissue contributes to metabolic heath, and might lead to strategies to combat obesity-related metabolic diseases like diabetes.

PI_NAMEs: GRANNEMAN, JAMES G (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Address;Adipocytes;Adipose tissue;Adult;Aging;Brown Fat;Cell Communication;Cell Lineage;cell type;Cells;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;combat;CRISPR/Cas technology;Data;Dendritic Cells;Diabetes Mellitus;Diet;dimensional analysis;Dimensions;Endocrine;Event;Fatty acid glycerol esters;Fluorescent in Situ Hybridization;Foundations;Funding;gain of function;Generations;Genetic;Goals;Health;high dimensionality;Image;Immune;immune function;Immunofluorescence Immunologic;in vivo;insight;Intervention;Knowledge;Life Cycle Stages;Location;loss of function;Macrophage;Maintenance;Maps;Messenger RNA;Metabolic;Metabolic Diseases;meter;Microscopic;Molecular;Mus;Nutritional;Obesity;Organ;Phenotype;Population;postnatal;postnatal development;progenitor;Proliferating;prospective;Proteins;Proteomics;recruit;Resolution;Signal Transduction;single molecule;single-cell RNA sequencing;Specificity;Stromal Cells;subcutaneous;Techniques;Technology;Testing;Tissues;trafficking;transcriptomics;Transplantation;Visceral;Work

PROJECT_TITLE: Analysis of Cellular Plasticity in White Adipose Tissue.

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative: Physical activity can benefit brain health by reducing the risk of dementia, improving cognition, and enhancing sleep quality in typically developed adults, but less is known about the impact of physical activity on brain health in adults with Down syndrome. The aim of this research is to develop and validate an objective assessment of physical activity in adults with Down syndrome using portable accelerometers before exploring the impact of physical activity on plasma biomarkers associated with Alzheimer’s disease, cognitive function, and sleep quality in adults with Down syndrome. This study will inform future physical activity research focused on preventing, delaying, or slowing the progression of Alzheimer’s disease in adults with Down syndrome and has the potential to be transferable to other health-related outcomes in this population.

PI_NAMEs: HELSEL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;Accelerometer;actigraphy;Address;Adult;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Award;Biological Markers;Biomechanics;brain health;career;Cause of Death;Cognition;cognitive function;Conduct Clinical Trials;Data;Data Analyses;dementia risk;Development;Down's Syndrome;experience;Fostering;Funding;Future;Goals;Guidelines;Health;High Prevalence;Hip region structure;improved;Indirect Calorimetry;Individual;Infrastructure;International;Investments;Kansas;Knowledge acquisition;Lead;Learning;Life;Life Style;Light;Link;Location;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic;moderate-to-vigorous physical activity;multidisciplinary;neuropathology;Outcome;Outcome Measure;Participant;Physical activity;Physical assessment;Physiological;Plasma;Population;portability;prevent;Process;Receiver Operating Characteristics;Research;Research Activity;Research Personnel;Risk Reduction;Sampling;Scientist;secondary analysis;sedentary;sedentary lifestyle;Sleep;Sleep disturbances;sleep quality;Strenuous Exercise;tau Proteins;Training;treadmill;United States National Institutes of Health;Universities;Validation;Walking;Wrist

PROJECT_TITLE: Assessment of Physical Activity for Alzheimer's Disease Research in Down Syndrome

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurosciences

PHR: PROJECT NARRATIVE: The focus of the proposed research is to develop a develop a high-performance portable Single Photon Emission Computed Tomography scanner for dynamic brain imaging.

PI_NAMEs: SABET, HAMID  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Alzheimer's Disease;Arizona;attenuation;Back;Biological Models;Brain;Brain imaging;cancer imaging;Cardiac;Cells;Clinical;clinical application;Collaborations;Collimator;Compensation;Complex;Computed Tomography Scanners;cost;Creativeness;Data;Dedications;Dementia;density;design;detector;Development;digital;Dimensions;Dose;Epilepsy;Evaluation;fabrication;Floods;Frequencies;Gamma Cameras;Geometry;Goals;Head;high resolution imaging;Human;human imaging;human study;Image;image reconstruction;imaging study;improved;Isotopes;Lasers;Lesion;Letters;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Mechanics;Modeling;mosaic pattern;Noise;novel;nuclear imaging;Optics;Parkinson Disease;Patients;Performance;portability;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Process;Property;prototype;REM Sleep Behavior Disorder;Research;Resolution;screening;Semiconductors;Signal Transduction;single photon emission computed tomography;Structure;System;Systems Integration;targeted imaging;Technetium 99m;Technology;Thick;Tracer;ultra high resolution;Update;Vertebral column;Visualization;Work

PROJECT_TITLE: High-performance SPECT for dynamic brain imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Services;Liver Disease;Organ Transplantation;Primary Health Care;Substance Misuse;Transplantation

PHR: PROJECT NARRATIVE  This project will address a critical gap in knowledge and care for liver transplant recipients with alcohol use disorder. We will develop and pilot test an integrated intervention for liver transplant and alcohol recovery centered around a community health worker providing coordinated care for patients after liver transplantation. The results of this project have the potential to improve access, equity, and long-term outcomes for the growing number of patients suffering from alcohol use disorder and alcohol associated liver disease.

PI_NAMEs: DAGEFORDE, LEIGH ANNE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;Address;Advocacy;Alcohol consumption;alcohol intervention;alcohol relapse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;care coordination;career;career development;Caring;Cause of Death;Chronic;Chronic Care;Cirrhosis;Clinic;Clinic Visits;Clinical;Communities;Community Health Aides;comorbidity;Complex;Comprehensive Health Care;Consolidated Framework for Implementation Research;Data Collection;Death Rate;Development;Disease remission;Disproportionately impacts women;Effectiveness;effectiveness outcome;effectiveness-implementation randomized trial;effectiveness/implementation trial;Environment;Equity;evidence base;Failure;Feasibility Studies;feasibility testing;feasibility trial;Feedback;Fostering;Funding;Future;Goals;Health;Health education;Heavy Drinking;Hispanic;Hybrids;Immunosuppression;implementation evaluation;implementation framework;implementation outcomes;implementation research;implementation science;Improve Access;improved;integrated care;Intervention;intervention program;Interview;K-Series Research Career Programs;Knowledge;Life;Liver diseases;liver transplantation;Managed Care;Manuscripts;Medical;medication compliance;medication nonadherence;meetings;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;model design;Modeling;mortality;multi-component intervention;multidisciplinary;novel;Organ Transplantation;Outcome;outreach;Participant;Pathway interactions;Patient Care;patient engagement;Patients;Persons;Pilot Projects;pilot test;pilot trial;post-transplant;Process;programs;Provider;Randomized;randomized trial;Reading;Recording of previous events;Recovery;Recovery Support;Recurrence;relapse prevention;Research;research and development;Research Personnel;Research Project Grants;Resources;Scientist;Services;Site;skill acquisition;skills;Solid;Standardization;Surgeon;Surveys;System;Testing;therapy development;Time;Training;transplant centers;Transplant Recipients;Transplant Surgeon;Transplantation;Transplantation Surgery;United States;Work

PROJECT_TITLE: Development and Testing of an Integrated Care Coordination Intervention for Alcohol Use Disorder Recovery after Liver Transplantation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Our research will provide a framework for understanding the role of transmission determinates in infectious  disease dynamics across a broad array of infectious disease systems. Our work will therefore contribute to  the control of infectious diseases to enhance human health and reduce illness.

PI_NAMEs: HOYT, JOSEPH RYAN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Affect;Behavior;Biological Process;Biology;Communicable Diseases;Complex;Data;Disease;Disease Outbreaks;Disease Outcome;Dose;Ecology;Environment;Epidemic;Event;Evolution;experimental study;exposure route;field study;Frequencies;Health;Heterogeneity;Human;Infection;infection risk;infectious disease evolution;insight;Interdisciplinary Study;mathematical model;Microbiology;Modeling;pathogen;pathogen exposure;pathogenic fungus;Probability;Research;Role;Route;Snakes;success;System;transmission process;Variant;Virulence;Work

PROJECT_TITLE: Sit-and-wait pathogens: Consequences of heterogeneity in pathogen exposure dynamics for environmentally persistent pathogens


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Hematology;Nanotechnology;Wound Healing and Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH Vascular anastomosis – the joining of two blood vessels using stitches – plays a central role in numerous life-saving surgeries, but has serious associated complications and long recovery times. These issues are currently addressed by the application of fibrin glues, but these materials have limited practical application due to cold chain requirements and short work time, and their high-density produces suboptimal healing outcomes. This proposed research will develop a novel colloidal microporous fibrin-based nanoparticle surgical sealant with improved work time and enhanced drug delivery profiles that boasts superior wound healing capabilities compared to traditional fibrin glues, allowing for faster operating times, fewer complications, improved recovery, and more widespread access by removing cold-chain requirements.

PI_NAMEs: MOISEIWITSCH, NINA ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Adhesives;Air Embolism;Anastomosis - action;Angiography;Benchmarking;Biocompatible Materials;Biological;Biological Assay;Blood Vessels;Cardiovascular Diseases;Cardiovascular Surgical Procedures;career;Carotid Arteries;Cells;Cellular Infiltration;Characteristics;Clinical Skills;Coagulation Process;cofactor;Cold Chains;Colloids;Consumption;Coronary Artery Bypass;Cryopreservation;density;design;Drug Delivery Systems;Drug vehicle;Endothelium;Evaluation;Exhibits;FGF2 gene;Fibrin;Fibrin Tissue Adhesive;Fibrinogen;Fibroblast Growth Factor;Fibroblasts;flexibility;Formulation;Freeze Drying;Gel;global health;Glues;Growth Factor;healing;health application;Hemorrhage;Hemostatic function;Histologic;histological specimens;Hyperplasia;improved;In Vitro;in vivo;in vivo evaluation;Infiltration;innovation;Lead;Left;Life;Ligation;Link;Marketing;mechanical properties;Mechanics;Medical;Microfluidics;Microscopy;Modality;Modeling;Morphology;nanoparticle;Natural Disasters;novel;novel therapeutics;Operative Surgical Procedures;Organ failure;Organ Transplantation;Oryctolagus cuniculus;Outcome;particle;Patients;Pharmaceutical Preparations;Phase;Physicians;Physiological;Play;polymerization;Polymers;Porosity;Postoperative Period;practical application;pressure;Procedures;Process;Property;Public Health;Recovery;release factor;repaired;Research;Research Technics;restenosis;Risk;Role;Safety;Scientist;sealant;Shapes;Site;Skin wound healing;Stenosis;Stimulant;Structure;success;surgery outcome;Surgical sutures;Techniques;Technology;Temperature;Testing;Thrombin;Thrombosis;Time;Tissue Sample;Training;Transplantation;Trauma;War;Work;wound closure;wound healing

PROJECT_TITLE: Fibrin-Based Nanoparticles as a Novel Sealant for Vascular Anastomosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative  Cardiovascular disease (CVD) is a leading cause of adult mortality and health inequity in the United States, with African Americans at the highest risk for CVD and African American youth at the highest risk for CVD risk factors. This research examines the relationship between structural racism (i.e., neighborhood-level racial disparities in the educational, employment, housing, and law enforcement systems) and biobehavioral processes involved in early CVD progression, including metabolic syndrome, endothelial function, and inflammation, and also tests inflammation as a possible mechanism explaining the association between structural racism and cardiometabolic health (i.e., metabolic syndrome and endothelial function) across 2 samples of African American youth and young adults over time. Examining the relationship between structural racism and biobehavioral processes involved in early CVD progression among African American youth has potential to provide significant impacts in terms of the prevention of CVD in future work.

PI_NAMEs: CHEN, MICHELLE A. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;adolescent health;Adult;Affect;African American;African American population;Age;Area;biobehavior;Biological Markers;Blood Pressure;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Childhood;Cholesterol;Clinical;cytokine;Data;Development;disease disparity;Disease Progression;Disparity;Education;Employment;Endothelium;Event;experience;Exposure to;Functional disorder;Future;Glucose;Goals;Health;health disparity;health inequalities;high risk;Housing;IL8 gene;Immunology;Imprisonment;Individual;Inflammation;Inflammatory;Interleukin-1 beta;Interleukin-10;Interleukin-6;knowledge base;Laboratories;Law Enforcement;Life;life span;Link;Literature;Longitudinal Studies;Measures;Mediating;Mediator;Metabolic syndrome;microbial;mortality;Myocardial Infarction;Neighborhoods;Not Hispanic or Latino;Obesity;Outcome;outcome disparities;Ownership;Participant;Pathogenesis;post-doctoral training;Process;Production;prospective;Public Health;Punishment;Race;racial difference;racial discrimination;racial disparity;racial population;Research;Risk Factors;Sampling;Schools;segregation;skills;social;Social Environment;Social Mobility;Statistical Methods;Structural Racism;System;Testing;Time;TNF gene;Training;Training Programs;Triglycerides;Unemployment;United States;Universities;waist circumference;Work;young adult;Youth

PROJECT_TITLE: Neighborhood-level Structural Racism and Cardiovascular Health Among African American Youth and Young Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Cardiovascular;Cerebrovascular;Emergency Care;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Rehabilitation

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Cardiac arrest survival remains unacceptably poor and currently no drugs exist that improve long-term survival with favorable neurological outcome. Agents such as TAT-PHLPP9c that target metabolic dysfunction may significantly improve outcomes and decrease the circuit flow rate required for successful extracorporeal cardiopulmonary resuscitation (eCPR), thereby broadening the availability of eCPR to wider populations including underserved areas. The main objective of this project is to evaluate the protective mechanism of TAT- PHLPP9c and its ability to improve the efficiency of eCPR.

PI_NAMEs: JUSTICE, CODY NICHOLAS (contact)

PROJECT_TERMS: 6-Phosphofructo-2-kinase;Adult;Affect;Biological Assay;Blood;Blood specimen;Brain;Cannulas;Cardiac;cardioprotection;Cardiopulmonary Resuscitation;Cells;Cerebrovascular Circulation;Cerebrum;Chicago;Development;Dichloroacetate;Emergency Situation;Ensure;experience;Family suidae;fatty acid oxidation;Glucose;glucose metabolism;glucose uptake;Goals;Heart;Heart Arrest;heart function;Hour;Illinois;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;intravenous administration;Ischemia;leucine-rich repeat protein;Leukocytes;Magnetic Resonance;Magnetic Resonance Imaging;Mammals;Mechanics;Mediating;Metabolic;Metabolic dysfunction;metabolic rate;Metabolism;Methods;Modeling;mouse model;Mus;Myocardial Ischemia;Myocardial Stunning;Neurologic Deficit;Neurological disability;Neurological outcome;neurological recovery;neuroprotection;NMR Spectroscopy;novel;Organ;out-of-hospital cardiac arrest;Outcome;oxidation;Oxygen;Pathologic;Patients;Penetration;Peptides;peripheral blood;Persons;PH Domain;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physicians;Population;porcine model;pre-clinical;prevent;Principal Investigator;Protein Dephosphorylation;Protein phosphatase;PTEN gene;Public Health;pyruvate dehydrogenase;Rattus;Recovery;Recovery of Function;Reperfusion Injury;Reperfusion Therapy;Resolution;Resuscitation;resuscitative care;Role;Sampling;Scientist;skills;SLC2A1 gene;small molecule;Specificity;survival outcome;Survivors;tat Protein;Techniques;Testing;Tissues;tool;Toxic effect;Training;Translating;underserved area;United States;Universities;Vanadium

PROJECT_TITLE: Peptide-Mediated Enhancement of Akt During Resuscitation and Reperfusion


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project narrative Sarcopenia is a leading cause of death and disability worldwide in older individuals, and it affects up to 25% of the population aged 70 and over. The ability to non-invasively image the earliest changes in sarcopenia progression is a critical unmet need that will help identify patients who can benefit the most from timely interventions. This work aims to develop a novel Magnetic Resonance Imaging (MRI) approach to study muscle quality as an early marker of sarcopenia progression, to provide new insight into sarcopenia pathogenesis and lead to timely intervention strategies to arrest the onset and progression of sarcopenia.

PI_NAMEs: MAZZOLI, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Affect;age related;age stratification;aged;Aging;aging population;Architecture;Atrophic;Biological Markers;Biology;biomechanical model;Biomechanics;biophysical model;Biopsy;Caring;Cause of Death;Cell Size;Clinical;clinical imaging;clinical research site;cohort;Collagen;Communities;cost;Deposition;Detection;Development;Diffusion Magnetic Resonance Imaging;disability;Disease;Early Diagnosis;Early identification;Elderly;Evaluation;Exercise Therapy;falls;Fatty acid glycerol esters;Fiber;Fibrosis;follow-up;frailty;functional improvement;functional outcomes;functional status;Geometry;Goals;Health;Health Care Costs;high risk;Histologic;Human;Image;imaging approach;Imaging Device;imaging modality;Individual;Infiltration;Inflammation;innovation;insight;Intervention;Length;Longitudinal Studies;Lower Extremity;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Medical;Methods;Mobility decline;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle strength;Muscular Atrophy;Musculoskeletal;Myopathy;non-invasive imaging;novel;novel imaging technique;novel therapeutics;Older Population;oscillating gradient spin echo;Outcome;Pathogenesis;Pathologic;Patients;Physical assessment;Physical Function;Physical Performance;Physiologic pulse;Population;preservation;Protocols documentation;Radiology Specialty;Reproducibility;Research;Research Personnel;Risk;sarcopenia;Sensitivity and Specificity;Severity of illness;Skeletal Muscle;Syndrome;Techniques;Tendon structure;Tissues;tool;Training;United States;vastus lateralis;Work

PROJECT_TITLE: Quantitative assessment of early structural and functional changes in aging skeletal muscle

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: TEMPE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Narrative Adolescent girls and young women living with HIV (AGYWLHIV) who have experienced intimate partner violence (IPV) have greater challenges in accessing healthcare for HIV, taking medication for HIV, and they have worse treatment outcomes. Male partner alcohol use directly and indirectly increases IPV risk among AGYWLHIV. This study will develop and pilot test a couples-based intervention to help AGYWLHIV (15-24 years) access HIV care and improve the outcomes of their HIV treatment by targeting male partner alcohol use to reduce IPV risk.

PI_NAMEs: KIENE, SUSAN MARIA;NWABUZOR-OGBONNAYA, IJEOMA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Africa South of the Sahara;aged;Alcohol consumption;alcohol intervention;Alcohols;antiretroviral therapy;arm;Behavior Control;Behavioral;binge drinking;Caring;Clinical Trials;Collaborations;comparison control;Conflict (Psychology);Control Groups;coping;Counseling;Country;Couples;Development;Disease;Disproportionately impacts women;Emotional;emotional abuse;Ever Married;experience;Female;Female Adolescents;follow-up;Future;Gender;health care availability;Heavy Drinking;Heterosexuals;HIV;HIV diagnosis;HIV Seronegativity;improved;improved outcome;informant;Intervention;intervention effect;intervention refinement;intimate partner violence;Love;male;Marriage;medication compliance;men;Men's Role;Mental Depression;motivational enhancement therapy;Outcome;Outcome Assessment;peer;Pharmaceutical Preparations;Physical aggression;pill;pilot test;Population;prevent;Process;Qualitative Research;Randomized;Recording of previous events;relationship abuse;Reporting;Research;Research Personnel;Risk;safety assessment;sexual coercion;Spouses;Stress;stress reduction;Testing;therapy adherence;transmission process;treatment as prevention;Treatment outcome;Uganda;Unsafe Sex;violence victimization;Viral;Viral Load result;Woman;young woman

PROJECT_TITLE: Improving HIV Care Engagement Among Ugandan Adolescent Girls and Young Women Through Reductions in Male Partner Alcohol Use and Intimate Partner Violence Risk: The Kisoboka Mukwano Intervention


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Clinical Research;Heart Disease;Neurosciences;Pediatric;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARATIVE Pediatric cardiac arrest affects thousands of children each year and for those who survive, many are left with significant neurologic injury. These clinical studies will inform our understanding of how cerebral physiology is impaired after cardiac arrest and identify mechanisms of preventable brain injury. The results will potentially lead to personalized cerebral physiology-targeted clinical trials to improve clinical outcomes from pediatric cardiac arrest.

PI_NAMEs: KIRSCHEN, MATTHEW P (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute Brain Injuries;Affect;Age;age related;Anisotropy;arterial spin labeling;Bilateral;Biometry;Blood Pressure;blood pressure control;Brain;Brain Hypoxia-Ischemia;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Cardiac;career;career development;Caring;Categories;cerebral autoregulation;cerebral hypoperfusion;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Characteristics;Child;Childhood;Clinical;clinical epidemiology;clinical practice;Clinical Research;Clinical Trials;constriction;Critical Care;Data;Dedications;Development Plans;Diffuse;Diffuse Brain Injury;Diffusion;Diffusion Magnetic Resonance Imaging;Doctor of Philosophy;Environment;epidemiology study;Event;experience;Fellowship;frontal lobe;Future;Goals;Heart Arrest;Homeostasis;Hospitals;Hour;hypoperfusion;hypoxic ischemic injury;Imaging Techniques;Impairment;improved;improved outcome;individual patient;Intervention Trial;Knowledge;Left;Magnetic Resonance Imaging;Master of Science;Measures;Mediating;Mediation;Mentors;Metabolic;Methods;Monitor;Morbidity - disease rate;mortality;Near-Infrared Spectroscopy;Nervous System Trauma;Neurologic;Neurological disability;Neurologist;Neurology;Neurosciences;non-invasive optical imaging;optical imaging;Optical Methods;Outcome;Patients;Pediatric cohort;Pediatric Hospitals;pediatric patients;Pennsylvania;Performance;Philadelphia;Physiological Processes;Physiology;pressure;prevent;primary outcome;programs;Qualifying;Radial;Recommendation;Research;Resuscitation;Scientist;Secondary to;Severities;skills;Spectrum Analysis;Testing;Time;Training;Training Programs;Translating;Universities;white matter

PROJECT_TITLE: Cerebral autoregulation and MRI measures of brain injury after pediatric-post cardiac arrest

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Transplantation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative The goals of this investigation are to follow dental patients that require bone grafts before their dental implant is placed and to demonstrate the potential diagnostic opportunities that ultrasound adds to the current standard of clinical dental care.

PI_NAMEs: CHAN, HSUN-LIANG ;KRIPFGANS, OLIVER D (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: 3-Dimensional;Adopted;Allografting;Anatomy;Assessment tool;Atrophic;Bacterial Infections;Blood;Blood flow;bone;bone healing;bone loss;bone quality;Bone Surface;Bone Transplantation;bone xenograft;care providers;Chronic;Classification;Clinical;clinical diagnostics;Clinical Research;Clinical Trials Design;Collaborations;cone-beam computed tomography;Dental;Dental Care;Dental caries;Dental Implants;dental structure;design;Diagnosis;Diagnostic;diagnostic value;Dimensions;Disease;disorder risk;Elements;Evaluation;Exclusion;experience;Face;Failure;Frequencies;Goals;graft failure;graft healing;healing;health disparity;health equity;Image;Imaging technology;Implant;Implantation procedure;improved;Industry;Infection;Inferior;Inflammation;Investigation;Ionizing radiation;Lateral;Lesion;Longitudinal Studies;Machine Learning;manufacture;Manufacturer;Measurement;Measures;meter;Methods;Miniaturization;Monitor;Morphology;National Institute of Dental and Craniofacial Research;Operative Surgical Procedures;Oral;oral care;Oral cavity;Organ Transplantation;Outcome;Particulate;Pathology;Patients;Penetration;Physiological;point of care;Procedures;Process;prototype;Quality of life;Radiation;Readiness;Research;Resolution;Roentgen Rays;Severities;Site;soft tissue;Strategic Planning;Structure;Surface;System;targeted treatment;Testing;Thick;Time;Time Study;Tissues;Tongue;tool;Tooth Extraction;Transducers;two-dimensional;Ultrasonography;ultrasound;United States;Visual;Visualization;Wait Time;Work

PROJECT_TITLE: Ultrasonic Imaging of Bone Graft Healing in Extraction Sockets for Precise and Personalized Implant Therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Kidney Disease;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE More than 300,000 older Americans are diagnosed with end-stage kidney disease and treated with long-term hemodialysis each year; the hemodialysis vascular access is their lifeline. Thus, identifying the type of dialysis vascular access that offers better patient outcomes is a public health priority. This multicenter randomized clinical trial will compare two vascular access placement interventions (fistula versus graft) in older patients; results will help us understand the relationships between vascular access type and clinical, economic, and patient-reported outcomes in this vulnerable and understudied population.

PI_NAMEs: ALLON, MICHAEL ;MUREA, MARIANA  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adjuvant;Adult;age related;Age Years;aging related disease;American;Anatomy;Arteriovenous fistula;arteriovenous graft;Assessment tool;Attention;Biological Factors;Blood Vessels;Capsicum;care preference;Caring;Catheters;Cessation of life;Characteristics;Chronic;Client satisfaction;Clinical;clinical practice;Clinical Trials;comorbidity;comparative;Complex;Coronary Arteriosclerosis;cost;Data;Dependence;Diabetes Mellitus;Diagnosis;Dialysis procedure;disability;Disadvantaged;Disease;Economics;Effectiveness of Interventions;eligible participant;End stage renal failure;Enrollment;evidence base;Exhibits;Failure;feasibility testing;Fistula;follow-up;frailty;Goals;Hand Strength;Health;health assessment;Health Care Costs;Health Services Accessibility;Hemodialysis;High Prevalence;Hospitalization;human old age (65+);Incidence;Infection;infection rate;infection risk;Intervention;Link;Longevity;Measurement;Measures;Medical center;novel;Observational Study;older adult;older patient;Operative Surgical Procedures;Outcome;Participant;Patient Outcomes Assessments;Patient Preferences;Patient-Focused Outcomes;Patients;Peripheral arterial disease;Physical Function;pilot trial;Population;primary outcome;Procedures;public health priorities;Randomized;randomized trial;randomized, clinical trials;Reporting;Research;Research Methodology;research study;Risk;Role;Safety;safety outcomes;satisfaction;Site;Testing;Time;Vascular Graft;Venous

PROJECT_TITLE: A Randomized Trial of Fistula vs. Graft Arteriovenous Vascular Access in Older Adults with End-Stage Kidney Disease on Hemodialysis: The AV ACCESS Trial

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Visual deficits cause morbidity, decrease quality of life and have a significant societal burden. In addition, the visual system is a unique, easily-accessed portal with which to detect, diagnose and monitor many systemic diseases. The University of Rochester’s Center for Visual Science T32 provides interdisciplinary training in advanced optical technology for vision correction and retinal imaging, cell biology and neural mechanisms of both normal and diseased vision, and the role of vision in behavior for graduate students and post-docs of 28 faculty mentors.

PI_NAMEs: HUXLIN, KRYSTEL R;TADIN, DUJE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training;vision science

PROJECT_TITLE: Training in Vision Science


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DOVER

ORG_NAME: EINSENCA INC.

ORG_STATE: DE

PHR: Alzheimer's disease (AD) is a devastating and progressive disease without a cure with an increasing prevlance. Aberrant oxidative neuroinflammation such as that driven by myeloperoxidase is a key early event in the development of Alzheimer's disease (AD). The goal of this proposal is to develop a noninvasive positron emission tomography (PET) imaging method to quantify and monitor myeloperoxidase-mediated oxidative stress in the AD brain.

PI_NAMEs: LARSON, ANDREW CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;age related decline;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Anti-Inflammatory Agents;Axon;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Cells;clinical imaging;clinical translation;Clinical Trials;Cyclic GMP;Demyelinations;Development;Diagnostic tests;Disease;Disease Progression;Early Diagnosis;Event;Evolution;first-in-human;fluorodeoxyglucose;Functional disorder;glucose metabolism;Goals;Human;Image;imaging agent;imaging modality;Imaging technology;Immune;immunoreactivity;Inflammation;Inflammatory;inhibitor;innovation;Mediating;Mediator;Monitor;Mus;neuroinflammation;Neurons;non-invasive imaging;non-invasive monitor;novel marker;Output;Oxidative Stress;Patients;Peroxidases;Phase;Positron-Emission Tomography;Prognosis;Progressive Disease;Proteins;Rattus;Reporting;response;tau Proteins;Technology;Testing;Toxicology;treatment response;Validation

PROJECT_TITLE: PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: WEST LAKE HILLS

ORG_NAME: ATOMO, INC

ORG_STATE: TX

PHR: Transthyretin Amyloidosis with cardiac myopathy, ATTR-CM, represent a serious healthcare issue. ATTR-CM is involved in 13% of heart failure, 16% of transcatheter aortic-valve replacement, and 5% of individuals with presumed hypertrophic cardiomyopathy. The primary challenge is that most patients are undiagnosed or their diagnosis is delayed for multiple years. Atomo, in partnership with PENN Medicine, will develop an AI-based Clinical Decision Support Solution called “PERCEPTION” that will flag probable yet undiagnosed ATTR individuals before they develop CM so they can be clinically evaluated and receive the proper diagnosis and therapy.

PI_NAMEs: MYERS, KELLY D (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Adoption;Amyloidosis;aortic valve replacement;artificial intelligence model;biobank;Cardiac;Cardiovascular Diseases;Clinical;clinical decision support;Clinical Decision Support Systems;clinical implementation;commercialization;Data;Databases;Department chair;design;Development;Diagnosis;Disease;effective therapy;Environment;experience;Familial Amyloid Neuropathies;Familial Hypercholesterolemia;Genetic;genetic testing;Goals;Health Care Costs;Healthcare;Heart;Heart failure;Hypertrophic Cardiomyopathy;improved;Individual;Inherited;insight;Journals;Low Prevalence;medical schools;Medicine;Modeling;Molecular Medicine;mortality;Myopathy;Patients;Peer Review;Pennsylvania;Performance;personalized screening;Phase;Phenotype;Prealbumin;Prevalence;Probability;professor;Prognosis;Publications;Publishing;Radionuclide Imaging;Random Allocation;Research;Risk;Services;Small Business Innovation Research Grant;success;Symptoms;System;technical report;Technology;Testing;Training;training data;Universities;Update;Work

PROJECT_TITLE: Finding undiagnosed ATTR-CM patients using AI technology in clinical settings


NIH_SPENDING_CATS: Cancer;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative This proposal seeks to identify genetic variances in the metabolism abiraterone, an androgen synthesis inhibitor, that can be used to identify abiraterone metabolites that may hasten disease progression. A clinical trial tests the efficacy of inhibiting metabolism of an active metabolite that may worsen outcomes. If positive, this trial of pharmacologic 5 alpha reductase inhibition may prolong the sensitivity to abiraterone in certain patients, delaying progression of the disease, symptoms and death and would validate the targeting of active abiraterone metabolites in this disease.

PI_NAMEs: HALABI, SUSAN  (contact);SHARIFI, NIMA

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: abiraterone;Acetates;acquired treatment resistance;Adrenal Glands;Adrenergic Antagonists;Affect;Agonist;Alleles;androgen independent prostate cancer;Androgen Metabolism;Androgen Receptor;Androgens;Androstenedione;Anions;arm;Automobile Driving;Biological Factors;Biological Markers;Biology;biomarker driven;Castration;Cessation of life;chemotherapy;Clinical;Clinical Trials;Data;dehydroepiandrosterone;design;Development;Disease;Disease Progression;Dutasteride;efficacy testing;enzalutamide;Enzyme Inhibition;Enzymes;Evaluation;experience;Failure;Fostering;Future;gain of function;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;genomic biomarker;Genomics;Genotype;high risk;Hydroxysteroid Dehydrogenases;Individual;inhibitor;inhibitor therapy;Ketoconazole;Malignant neoplasm of prostate;Mediating;member;men;Metabolism;Modeling;Neoadjuvant Therapy;Nomograms;novel;Outcome;Oxidoreductase;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;phase 2 study;Phase III Clinical Trials;phase III trial;Play;Population;predicting response;Prevalence;Process;Production;prognostic model;prognostic of survival;Progression-Free Survivals;prospective;Race;radiological imaging;Randomized;Residual Neoplasm;Resistance;Resistance profile;response;Risk;Role;Science;Selection Criteria;Selection for Treatments;Series;Serology;Serum;solute;SRD5A2 gene;study population;success;Symptoms;targeted treatment;Testing;Testosterone;Testosterone 5-alpha-Reductase;therapy resistant;TP53 gene;treatment strategy;tumor;tumor progression;uptake;Variant;Work

PROJECT_TITLE: Interactions of Androgen Production, Uptake and Metabolism on outcome in Castration Resistant Prostate Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Genetics;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE: This proposed research is relevant to public health because it is expected to identify the mechanism(s) that result in maladaptive lung fibroblast differentiation and extra cellular matrix deposition, which can be found in chronic neonatal lung diseases, such as Bronchopulmonary Dysplasia, and adult-onset fibrotic lung diseases, such as idiopathic pulmonary fibrosis. Development of regenerative therapies, leading to restoration of lung structure and function, in chronic lung diseases will need to be guided by insights into the mechanistic underpinnings of defective alveolarization. The proposed research is relevant to the part of NIH’s mission pertaining to developing fundamental knowledge that will inform the upstream regulation and downstream function of matrix fibroblasts with the ultimate objective to restore a microenvironment that is permissive for alveolar repair and allow for better engraftment in cell replacement approaches using iPSC derived cells.

PI_NAMEs: PERL, ANNE-KARINA THERESIA (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adhesions;Adult;Alveolar;alveolar epithelium;Alveolus;Animal Model;Basal Cell;Basal lamina;Binding;Biological Assay;Bronchopulmonary Dysplasia;Cell Communication;Cell Differentiation process;Cell Proliferation;Cells;Characteristics;ChIP-seq;Chromatin;Chronic lung disease;Cleavage Under Targets and Release Using Nuclease;cofactor;Collagen;comparative;Data;Data Set;Deposition;Development;Dysplasia;Engraftment;Epigenetic Process;Epithelial Cells;Epithelium;experimental study;Extracellular Matrix;EZH2 gene;fibroblast growth factor 18;Fibroblasts;Fibrosis;fibrotic lung disease;Future;gain of function;GATA6 transcription factor;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Homeostasis;Human;Hyperoxia;Hyperplasia;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vitro Model;induced pluripotent stem cell;Infant;inhibitor;innovation;insight;intercellular communication;Knowledge;Lipids;loss of function;Lung;Lung Diseases;lung injury;lung regeneration;Membrane;Mission;Modeling;Modification;Molecular;Mus;Natural regeneration;Nature;Nuclear;Organoids;overexpression;paracrine;Paracrine Communication;Patients;Perinatal;perinatal period;permissiveness;pharmacologic;Population;postnatal;Premature Infant;promoter;Proteomics;Public Health;Pulmonary Emphysema;regenerative therapy;Regulation;Regulatory Element;repaired;Replacement Therapy;Reporting;Repression;Reproducibility;Research;restoration;Role;self-renewal;Signal Transduction;Site;small hairpin RNA;Specific qualifier value;Structure;Testing;therapy development;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptomics;transdifferentiation;United States National Institutes of Health;WNT Signaling Pathway

PROJECT_TITLE: Role of alveolar fibroblasts in extracellular matrix organization and alveolar type 1 cell differentiation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Despite great advances in neuroscience, many neurological disorders remain without treatment options. The goal of the NeuroNEXT Network and the Clinical Coordination Center is to develop, coordinate, and conduct clinical trials to advance treatments of neurological disorders across the lifespan. Continuing the work of NeuroNEXT and adding innovations will expedite the development of neurological treatments and expand the pool and diversity of experienced clinical Investigators and research staff leaders.

PI_NAMEs: CUDKOWICZ, MERIT E (contact);VIDENOVIC, ALEKSANDAR

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Academia;Acceleration;Achievement;Acute;Adult;Agreement;Area;Biological Markers;biomarker validation;Bylaw;Child;Childhood;Chronic;Clinical;clinical biomarkers;Clinical Investigator;Clinical Research;clinical research site;clinical trial participant;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collaborations;Common Data Element;Communication;Communities;Community Networks;Conceptions;Conduct Clinical Trials;Contracts;cost;Data Collection;Data Coordinating Center;Decentralization;Development;Disease;early phase clinical trial;Education;Ensure;equity, diversity, and inclusion;experience;Family;Foundations;Funding;gene therapy;gene therapy clinical trial;Gene therapy trial;Goals;Government;improved;Individual;Industry;industry partner;innovation;Institution;Institutional Review Boards;investigator training;Knowledge;Laboratories;Lead;Leadership;life span;Link;Methodology;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;Nature;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic;Neurosciences;novel;novel strategies;novel therapeutics;organizational structure;outreach;Participant;patient oriented;patient population;Patients;performance site;Periodicals;Persons;Pharmacy facility;Phase;Phase II Clinical Trials;Population;Privatization;Procedures;Process;programs;protocol development;Protocols documentation;Rare Diseases;recruit;Reporting;Research;Research Personnel;Safety;Site;Societies;Standardization;study population;symposium;Teleconferences;Testing;therapeutic development;therapy development;Training;Training and Education;Translating;trial design;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Clinical Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - CCC)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE: The proposed project aims to address the current absence of a culturally and contextually relevant, and validated tool to measure readiness for change (RFC) among non-specialist health workers (such as community health workers) for the adoption and successful implementation of mental health task-sharing. Such a measurement tool is relevant to public health because it could lead to systematic investigation of strategies to build RFC in this population and enhance their adoption of mental health task-sharing and the fidelity with which they deliver it. This will ultimately help alleviate the challenges brought upon by the dearth of mental health professionals globally, including low-resource settings in the United States, and thus, the proposed research is also relevant to the part of NIMH's strategic plan to build models to scale-up evidence-based practices for use in routine care settings.

PI_NAMEs: DEV, SALONI  (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Accreditation;Address;Adopted;Adoption;Affect;Attention;Attitude;Belief;Caring;cognitive interview;Community Health Aides;Community Healthcare;cost effectiveness;COVID-19 pandemic;Ensure;Evidence based practice;Factor Analysis;Female;Foundations;Funding Mechanisms;Future;Goals;Health;health care availability;health care settings;Health Professional;implementation barriers;implementation strategy;improved;Incentives;indexing;India;Individual;Intervention;Investigation;Knowledge;Language;Learning;Literature;low and middle-income countries;Measurement;Measures;medical specialties;Mental Health;Mental Health Services;model building;Modeling;Motivation;National Institute of Mental Health;Outcome;Outcome Study;Population;Primary Care;Primary Health Care;Privatization;programs;provider factors;psychologic;Public Health;Quality of Care;Randomized, Controlled Trials;Readiness;Recommendation;Research;Resource-limited setting;Role;routine care;scale up;Self Efficacy;Services;skills;social;Solid;Strategic Planning;structural determinants;Structure;Supervision;System;Target Populations;Testing;tool;Translating;Translations;United States;United States National Institutes of Health;usability;Validation;Validity and Reliability;willingness;Work;World Health Organization

PROJECT_TITLE: Readiness for Change Scale: Adaptation and Validation for Mental Health Task-Sharing

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Nutrition;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative There are currently no FDA-approved therapies for Type I hyperlipoproteinemia, a rare, autosomal recessive metabolic disorder characterized by extreme hypertriglyceridemia due to a deficiency of lipoprotein lipase or related proteins. Our recent preliminary data in two children and an adult with T1HLP revealed 46-60% reduction in fasting serum triglycerides with Orlistat with only minimal side effects. Therefore, we wish to study the long-term efficacy and safety of orlistat for reducing serum triglyceride levels in patients with T1HLP in a randomized, double- blind, placebo-controlled, cross-over trial with an open-label extension.

PI_NAMEs: GARG, ABHIMANYU  (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: 9 year old;absorption;acute pancreatitis;Admission activity;Adult;apolipoprotein B-48;Apolipoproteins;Atherosclerosis;autosome;Body Weight;Chemistry;Child;chronic pancreatitis;Cirrhosis;Clinical;Clinical Research;Clinical Trials;Consumption;Coronary heart disease;Cross-Over Studies;Cross-Over Trials;Data;Dependovirus;Development;Diabetes Mellitus;diacylglycerol O-acyltransferase;Diagnosis;dietary;Dietary Fats;Disease;disease-causing mutation;Docosahexaenoic Acids;Double-Blind Method;double-blind placebo controlled trial;early childhood;effective therapy;Eicosapentaenoic Acid;Enrollment;Equilibrium;Evaluation;Excretory function;Familial Hypercholesterolemia;Familial Lipoprotein Lipase Deficiency;Fasting;Fat-Restricted Diet;Fat-Soluble Vitamin;Fatty acid glycerol esters;fecal microbiota;Fibrates;Fish Oils;gastrointestinal;gastrointestinal symptom;gene therapy;Hepatic;Hepatosplenomegaly;Hour;Hyperlipoproteinemia;Hypertriglyceridemia;infancy;inhibitor;Inpatients;Intestines;Life;Lipase;lipoprotein lipase;Lipoproteins;Liver;Longitudinal Studies;loss of function;Loss of Heterozygosity;Low-Density Lipoproteins;male;man;Marketing;Measures;Metabolic Diseases;microsomal triglyceride transfer protein;Minerals;Modeling;Morbidity - disease rate;mortality;Nephrolithiasis;Nicotinic Acids;novel therapeutics;older women;Omega-3 Fatty Acids;open label;orlistat;Outcome;Oxalates;Pancreas;Patients;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Plasmapheresis;Prevalence;prevent;primary endpoint;Procedures;Proteins;Quality of life;Questionnaires;Randomized;Recurrence;Reporting;Research Design;Research Personnel;Risk;Safety;screening;secondary endpoint;Serum;side effect;Spleen;Steatorrhea;Stomach;Syndrome;Testing;Thrombocytopenia;Time;Toxic effect;trial design;Triglycerides;United States Food and Drug Administration;Urine;Xanthomas

PROJECT_TITLE: Long term efficacy and safety of orlistat for type 1 hyperlipoproteinemia: a randomized, double-blind, placebo-controlled trial


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Public Health Relevance Inhibitory circuits in the auditory tectothalamic pathway critically shape speech and vocalization processing, sound localization and other neural computations that are crucial for hearing. This proposal aims to determine how GABA and NPY signaling, from a distinct class of inferior colliculus (IC) neurons, work in concert to shape sound processing in the IC and auditory thalamus. Furthermore, this proposal will determine how NPY signaling can enhance detection of auditory cues in a mouse model of aging. The results of this proposal will provide important new information about how a defined inhibitory neural circuit contributes to the ability of IC and thalamic neurons to produce selective responses to communication sounds. In addition, this research will provide a mechanistic foundation for the development of therapeutic agents to manipulate inhibitory signaling to improve hearing for those who suffer from age-related hearing loss.

PI_NAMEs: SILVEIRA, MARINA AUGUSTO (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Affect;Aging;Animal Vocalization;Auditory;auditory pathway;auditory processing;auditory thalamus;Brain region;Communication;Complex;Critical Pathways;Cues;Detection;Drug usage;Electrophysiology (science);Elements;Equilibrium;experimental study;Family;Foundations;Frequencies;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Hearing;improved;In Vitro;in vivo;Inferior Colliculus;Ipsilateral;Learning;Maps;Medial;molecular marker;Morphology;mouse model;neural;neural circuit;Neural Inhibition;Neuromodulator;neuronal excitability;Neurons;neuropeptide Y;neuropeptide Y-Y1 receptor;Neuropeptides;neuroregulation;Neurotransmitters;novel;old mice;optogenetics;Outcomes Research;Pathway interactions;Pharmacology;Phase;Population;Positioning Attribute;postsynaptic;Presbycusis;Property;public health relevance;receptive field;receptor;Research;response;Role;Shapes;signal processing;Signal Transduction;skills;sound;Sound Localization;Speech;speech processing;Synapses;synaptic inhibition;Testing;Tetraodontidae;Thalamic structure;therapeutic development;Viral;vocalization;Work

PROJECT_TITLE: GABA and NPY Signaling Interact to Shape Inhibition in the Auditory Tectothalamic Pathway

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Chronic infection with hepatitis B virus (HBV) presents a global public health burden affecting 296 million individuals worldwide, who are at high risk of developing severe liver diseases, including cirrhosis and hepatocellular carcinoma, and will die without therapeutic intervention or liver transplantation. Our proposed research seeks to render woodchucks susceptible to HBV infection by modifying either the virus or host. Our project will provide a much-needed animal model for developing new, curative HBV-specific drugs for the treatment of patients.

PI_NAMEs: HU, JIANMING ;MENNE, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acute;Acute Hepatitis;Adenoviruses;Adult;Affect;age related;Animal Model;Animals;anti-hepatitis B;Anti-viral Agents;Antigens;Blood;Cell Culture Techniques;Cell Line;Cessation of life;Chimera organism;Chronic;Chronic Hepatitis;Chronic Hepatitis B;chronic infection;Cirrhosis;Competence;curative treatments;Data;Development;Disease Progression;Engineering;Evaluation;Evolution;Gene Expression;Genes;Genetic Enhancer Element;Hepatic;Hepatitis B Infection;Hepatitis B Virus;Hepatitis Viruses;Hepatocyte;hepatoma cell;high risk;Histopathology;Human;Immune;Immune response;Immune system;Immunocompetent;immunosuppressed;improved;In Vitro;in vivo;Individual;Infection;Intervention;intrahepatic;Life Cycle Stages;Liver;liver biopsy;Liver diseases;liver transplantation;Measures;Modeling;Mutagenesis;Mutation;Na(+)-taurocholate-cotransporting peptide;Neonatal;neonatal infection;Patients;permissiveness;Persons;Pharmaceutical Preparations;Pharmacotherapy;preclinical evaluation;Predisposition;pressure;Primary carcinoma of the liver cells;Productivity;promoter;Public Health;receptor;receptor binding;reconstitution;Research;RNA;Role;Satellite Viruses;Sequence Analysis;Serum;Study models;Supporting Cell;Testing;Therapeutic Intervention;Time;Tropism;vector;Viral;viral DNA;Viral Genes;Viral hepatitis;Viremia;Virion;Virus;virus development;Virus Diseases;Woodchuck;Woodchuck Hepatitis B Virus;Work

PROJECT_TITLE: Developing Woodchucks Susceptible to Hepatitis B Virus Infection by Modifying the Virus or Host

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 DF-M (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Cerebrovascular;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Rift Valley fever virus is a mosquito-borne virus present throughout Africa that causes significant disease; infection of the brain is a complication of disease that can lead to death or disability. In this project we will define how the virus travels from the site of infection in the skin to the brain and will identify which cells need to be infected by the virus for entry into the brain to occur. Understanding how the virus gets to the brain is a necessary first step to enable development of therapies to prevent this complication of disease.

PI_NAMEs: MCELROY, ANITA K (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute Hepatitis;Address;Africa;Ataxia;Biological Models;Bite;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Category A pathogen;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cessation of life;Clinical;Complication;Culicidae;Data;Dichloromethylene Diphosphonate;disability;Disease;Distal;Encephalitis;Endothelial Cells;Endothelium;Engineering;Event;experimental study;Fever;Future;Hematopoietic;hemiparesis;Hepatitis;Hepatocyte;Human;Immune;In Vitro;in vitro Model;in vivo;in vivo Model;Inbred Mouse;Infection;Inflammation;Injections;Interruption;Intervention;Invaded;Knowledge;Laboratory mice;Left;Leukocytes;Lymphocyte;Mediating;Meningism;mental state;MicroRNAs;Modeling;Mononuclear;Morbidity - disease rate;mortality;mosquito-borne;mouse model;Mus;Myeloid Cells;National Institute of Allergy and Infectious Disease;Neurologic;Neurons;Neuropathogenesis;neurotropic virus;neutrophil;novel;Organ;Pathogenesis;Patients;Peripheral;Peripheral Nerves;Phagocytes;prevent;Process;Public Health;Recombinant Inbred Strain;recombinant virus;Recombinants;Research;Rift Valley fever virus;Rodent;Role;Route;Sampling;sciatic nerve;Seizures;Series;Site;Skin;System;Testing;Therapeutic;therapeutic development;therapy development;Tight Junctions;trafficking;transcytosis;transmission process;Travel;Vaccines;Viral;Viral Genome;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Neuropathogenesis of Rift Valley fever virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LG-M (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project narrative/Relevance statement West Nile Virus (WNV) is a pathogen of global concern, which can invade the central nervous system to cause severe and debilitating encephalopathy. The proposed studies will use newly developed unique mouse models, recombinant viral strains and cutting edge sequencing approaches to study the causes and consequences of WNV neuroinvasive disease.

PI_NAMEs: GALE, MICHAEL  (contact);OBERST, ANDREW ATWELL

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Address;antagonist;Area;blood-brain barrier crossing;Cell Survival;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Central Nervous System Viral Diseases;Cessation of life;Cognitive;conditional knockout;Coupled;Culicidae;cytokine;design;Development;Differentiation Antigens;Disease;Disease Outcome;Encephalitis;Encephalopathies;Enterobacteria phage P1 Cre recombinase;epigenomics;Fatality rate;Fever;Flavivirus;Genes;genetic signature;Genetic Transcription;Goals;Hospitalization;Human;Human Bites;Immune response;Immunity;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;innate immune mechanisms;Innate Immune Response;Interferon Type I;Interferons;Intervention;Invaded;ITGAX gene;knockout animal;Knockout Mice;Knowledge;Link;long-term sequelae;Macrophage;Maps;Mediating;Melanoma;Memory Loss;Methods;Modeling;Molecular;Motor;mouse model;mRNA sequencing;multiple omics;Mus;Muscle Tremors;Muscle Weakness;Myeloid Cells;nano-string;Neuroglia;Neurons;neuropathology;neurovirulence;novel;Output;pathogen;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Phenotype;Play;Property;Proteins;Psyche structure;Public Health;Publishing;Recombinants;Recovery;Reporter;Reporting;response;Role;Severities;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Source;Survivors;symptom treatment;Systems Biology;Tissues;tool;transcriptome sequencing;transcriptomic profiling;transcriptomics;transmission process;Tretinoin;Vaccines;Viral;Viral Genome;Virus;Virus Diseases;virus host interaction;West Nile Encephalitis;West Nile viral infection;West Nile virus;Work

PROJECT_TITLE: Innate Immune Mechanisms Controlling Flavivirus Neurovirulence


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: NEW BRIGHTON

ORG_NAME: SYNAPTIC HEALTH LLC

PHR: Project Narrative  Alzheimer’s disease is a progressive debilitating disease with no known cure and is the 5th leading cause of death for Americans over the age of 65. There is strong evidence that poor sleep quality accelerates the progression of Alzheimer’s disease. To help slow the advancement of Alzheimer’s disease, we are developing a wearable peripheral neuromodulation device to improve sleep and reduce the burden of this disease.

PI_NAMEs: KROHN, BRIAN  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Architecture;Area;Autonomic nervous system;Behavior;burden of illness;Cause of Death;Clinical;Clinical Research;Clinical Trials;commercialization;cost estimate;Data;Dementia;dementia risk;Deposition;depressive symptoms;design;Detection;Devices;Disease;Disease Progression;Economic Burden;efficacy testing;Electroencephalography;experience;Eye;Face;Failure;Feedback;foot;Forehead;Future;Goals;Hand;Health Care Costs;Healthcare Systems;Heating;high risk;Human;human old age (65+);Impaired cognition;improved;improvement on sleep;In Vitro;in vitro testing;Individual;innovation;Liquid substance;Masks;Maxillary Sinus;Medical;Medical Device;Minor;neuroregulation;non rapid eye movement;novel;novel strategies;Onset of illness;Participant;Pathogenicity;Patients;Peripheral;personalized medicine;Phase;Phase II Clinical Trials;poor sleep;Positioning Attribute;prevent;product development;Prospective Studies;Proteins;prototype;Questionnaires;Research;Research Personnel;Risk;Risk Reduction;sensor;Sinus;Skin;Skin Temperature;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;sleep onset;sleep quality;Sleep Stages;Slow-Wave Sleep;Surface;System;tau Proteins;Temperature;Testing;Time;Toxin;Treatment Efficacy;United States;usability;Validation;Variant;voltage;wearable device

PROJECT_TITLE: A novel closed-loop feedback neuromodulation system for improving slow wave sleep in Alzheimer's disease patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-C (10)]


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: BOGOTA

ORG_COUNTRY: COLOMBIA

ORG_FIPS: CO

ORG_NAME: COLOMBIAN NATIONAL INSTITUTE OF HEALTH

PHR: The proposed research activities will contribute to the prevention, detection, response and containment of public health threats posed by infectious diseases and to reduce the resulting burden and disabilities in Colombia. For Year 1 of this proposed cooperative agreement, three projects are proposed that address research issues on relevant infectious diseases for Colombia, with the ultimate goal of improving public health. The three projects are centered on research of acute febrile illness (AFI) and related aspects to guide public health interventions and detect emerging threats to better define the burden, risk, and effectiveness of available prevention interventions to mitigate their impact.

PI_NAMEs: MONTILLA, EFRAIN ANDRES (contact)

PROJECT_TITLE: GH20-003, Excellence in Research for Emerging and Reemerging Diseases of Public Health Interest in Colombia at the National Institute of Health


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE: Nighttime suppression of melatonin production by retinal light exposure poses health risks to nightshift workers like nurses, who are habitually exposed to high nighttime ambient light levels and specific short- wavelength (blue) light emitted by self-luminous computer displays. Our innovative research project proposes an unprecedented combination of two strategies – 1) use of blue-blocking filters, and 2) monocular circadian light exposures, in an attempt to preserve nighttime melatonin levels in night shift working nurses without compromising their visual and operating performance and sleepiness levels.

PI_NAMEs: FIGUEIRO, MARIANA GROSS;REA, MARK S (contact)

PROJECT_TITLE: Filtered eyewear to prevent light-induced melatonin suppression while maintaining visual performance and alertness in night-shift working nurses

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]