NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE As the lung develops, precisely timed interactions between epithelial and mesenchymal cells promote the growth of new alveoli and the differentiation of alveolar type 2 cells into alveolar type 1 cells. Preterm birth during the saccular stage disrupts this process leading to dysregulation of two key signaling pathways – Wnt and BMP – with resulting arrested lung development and permanent deficits in pulmonary function. In this proposal, we will synthesize data from live microscopy, single-cell multiomics, and spatial transcriptomics to define the role of Wnt and BMP signaling in normal alveologenesis and in neonatal lung injury, which will provide foundational data for new approaches to restore normal lung growth after preterm birth.

PI_NAMEs: SUCRE, JENNIFER MALCOLMSRYGLEY (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Agonist;Alveolar;alveolar epithelium;Alveolus;antagonist;Architecture;Blood capillaries;Bronchopulmonary Dysplasia;capillary bed;Capillary Endothelial Cell;Cell Differentiation process;cell motility;Cell Nucleus;Cell Proliferation;Cells;Chromatin;Collagen;Data;delivery complications;Development;Distal;Endothelial Cells;Endotoxins;Epithelial Cells;Epithelium;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fluorescent in Situ Hybridization;Four-dimensional;Generations;Genetic Transcription;Goals;Growth;Health;high risk;Human;Hyperoxia;Image;Immunofluorescence Immunologic;Impairment;in vivo;Inflammation;inhibitor;Injury;innovation;Knowledge;Laminin;Libraries;Light;Lung;lung development;lung injury;Mesenchymal;Microscopy;Modeling;Molecular;Molecular Target;multiple omics;Myofibroblast;neonatal exposure;neonatal injury;neonatal lung injury;neonatal mice;neonate;new growth;novel strategies;overexpression;Pathway interactions;Pattern;Phenotype;postnatal;Pregnancy;Premature Birth;Premature Infant;Process;Production;Proliferating;Publishing;pulmonary function;real-time images;recruit;Regulation;Reporter;Resolution;response;restoration;Role;Sampling;scaffold;second harmonic;Signal Pathway;Signal Transduction;Slice;spatial relationship;spatiotemporal;Structure;temporal measurement;Testing;Therapeutic;Time;transcriptome sequencing;transcriptomics;Transgenic Organisms;Visualization;WNT Signaling Pathway

PROJECT_TITLE: Integrated Molecular and Cellular Drivers of Alveologenesis


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Pulmonary Fibrosis

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The goal of this project is to develop an integrated image-based AI survival prediction model for the prediction of mortality and disease progression in patients with progressive fibrosing interstitial lung disease. Successful development of the model will provide a prognostic biomarker that will significantly improve the accuracy of the current state-of-the-art in prognostic prediction, thereby ultimately making it possible to establish a widely used staging system for enabling effective management of patients with the progressive fibrosing interstitial lung disease.

PI_NAMEs: YOSHIDA, HIROYUKI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3-Dimensional;Adverse drug effect;Artificial Intelligence;artificial intelligence model;Biological Markers;Chest;Clinical;Clinical Trials;comparative;cost;Data;Databases;Decision Making;deep learning;design;Development;Disease;Disease Progression;Dyspnea;Evaluation;Fibrosis;fibrotic interstitial lung disease;generative adversarial network;Goals;High Resolution Computed Tomography;Image;imaging Segmentation;immunomodulatory therapies;improved;indexing;Intervention;Learning;Logistic Regressions;Measures;Methods;model development;Modeling;mortality;network models;Network-based;novel;novel therapeutics;Patient imaging;Patients;Performance;personalized predictions;predictive modeling;Prognosis;prognostic;Prognostic Marker;prognostic model;prognostic performance;pulmonary function;Reproducibility;response;Scheme;Staging System;supervised learning;Survival Analysis;survival prediction;System;Testing;Therapeutic;Time;Training;training data

PROJECT_TITLE: Survival prediction in patients with progressive fibrosing interstitial lung disease

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative As a Vet-LIRN Laboratory the Indiana ADDL will participate in testing exercises and surveillance testing, as well as methods standardization for potential regulatory use. The ADDL will participate in interlaboratory exercises and will serve as a source laboratory for the AMR project.

PI_NAMEs: HENDRIX, GENA KENITRA (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: CVM Vet-LIRN Veterinary Diagnostic Laboratory Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

ORG_STATE: NC

PHR: NARRATIVE A need exists for more pediatric clinical research to ensure that children are receiving appropriate medications, treatments, and devices that have been tested with children rather than adults. However, recruitment and retention in pediatric clinical trials remains a challenge. Parents play an important role in the decision-making process about their child’s participation in a clinical trial and a number of factors (e.g., awareness; knowledge; trust; fear) may inform their decision. Parents are in need of resources to help them better understand pediatric clinical research as well as facilitate high quality communication and shared decision-making skills related to their child’s participation in pediatric clinical trials. Thus, the goals of this application are to develop and test the feasibility of a web-based parent toolkit about pediatric clinical research (available in English and Spanish) using a user-centered approach that includes the voices from a diverse group of parents. This toolkit will have an impact on the field of pediatric health by providing parents with information and skills that are expected to increase pediatric clinical trial accrual.

PI_NAMEs: PARKER, ALISON ELAINE (contact);SCULL, TRACY MARIE

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: active control group;Address;Adolescent;Adult;Age;aged;Attitude;Awareness;Behavior Therapy;Child;Childhood;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Computers;Consumer Satisfaction;Dangerousness;Decision Making;design;Development;Devices;Disease;effectiveness evaluation;Enrollment;Ethnic Origin;Evaluation;Evaluation Studies;evidence base;experience;Familiarity;Family Practice;Feasibility Studies;feasibility testing;Feedback;Feeling;Foundations;Fright;Gender;Goals;group intervention;handheld mobile device;Health;Health Promotion;Human;human centered design;improved;information gathering;innovation;Institution;Internet;Joints;Knowledge;Language;Latina;Latino;Latinx;Literature;Logistics;Measures;Medical;Medicine;member;Methods;Minority Groups;Modeling;Multimedia;news;online resource;Online Systems;optimism;Outcome;parental influence;Parents;Patient Self-Report;Pharmaceutical Preparations;Play;Procedures;Process;programs;Questionnaires;Race;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resources;Risk;Role;Sample Size;Sampling;Self Efficacy;shared decision making;side effect;skills;social influence;Solid;Spanish/English;Tablets;Testing;theories;Thinking;Time;Travel;Trust;Uncertainty;usability;Voice;web page;web site;willingness;Youth

PROJECT_TITLE: User-centered approach to the development of a parent toolkit to improve willingness to participate in pediatric clinical research

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

ORG_STATE: PA

PHR: Project narrative  1. Increasing the capacity of laboratories conducting pathogen susceptibility  testing by funding the updating or purchasing of additional equipment.  Pennsylvania Veterinary Laboratory will participate in pathogen susceptibility  testing as per the requirement of the program. Funds are needed for  purchase of media, reagents and consumables used in pathogen  susceptibility testing and offer services for case investigation. 2. Procurement of supplies needed for NGS testing efforts or method improvement.  Laboratory is expanding Next Generation Sequencing using Illumina MiSeq  platform. Support for reagents and consumables will help with validation and  testing of the platform for investigations related to LIRN

PI_NAMEs: TEWARI, DEEPANKER  (contact)

PROJECT_TITLE: VET-LIRN Network capacity building projects..


ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: OH

PHR: FDA CVM Vet-LIRN PROGRAM (U18) GRANT PROPOSAL  FOR FOA # PAR-22-063 from the OHIO DEPARTMENT OF AGRICULTURE, ANIMAL DISEASE DIAGNOSTIC LABORATORY PROJECT NARRATIVE The FDA Veterinary Laboratory Investigation and Response Network (Vet-LIRN) enables analyses of animal diagnostic samples and animal food/drug products. Through Vet-LIRN, the FDA leverages the expertise of a national network of veterinary diagnostic laboratories to provide additional capability and capacity to strengthen the overall national food safety system. The Ohio Animal Disease Diagnostic Laboratory (ADDL) will offer its expertise and services to support testing and surveillance projects under direction from Vet-LIRN, provide surge capacities for testing using standardized Vet-LIRN methods, and assist Vet-LIRN with emergency response testing.

PI_NAMEs: PRARAT, MELANIE  (contact)

PROJECT_TITLE: FDA Vet-LIRN Infrastructure Support for Ohio ADDL


ORG_CITY: ANNAPOLIS

ORG_NAME: MARYLAND STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: MD

PHR: Project Narrative: Recent years have seen an increase in the threats to the food safety and security of both human and animal food supplies. In the proposed cooperative agreement Frederick Animal Health Laboratory will partner with the Veterinary Laboratory Investigation and Response Network (Vet- LIRN) to provide increased resources for the investigation of and response to animal food related illnesses.

PI_NAMEs: ABRAMO, KIMBERLY HARRS (contact)

PROJECT_TITLE: CVM Vet-LRN Veterinary Diagnostic Laboratory Program MD Dept of Agriculture- Frederick Animal Health Lab


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Endocrine Disruptors;Nutrition;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Epidemiological studies have identified strong links between short sleep, the metabolic syndrome and diabetes, and laboratory studies have demonstrated downstream mechanisms by which sleep restriction impairs glucose metabolism, including reduced insulin sensitivity. However, sleep restriction in both free-ranging humans and prior experimental studies is accompanied by longer exposure to Artificial Light At Night (ALAN), an endocrine disruptor that can profoundly disrupt circadian rhythmicity. We will evaluate the extent to which ALAN-induced endocrine and circadian disruption is a primary upstream toxic exposure contributing to the sleep-restriction- induced impairment of glucose metabolism and consequent increase in diabetes risk.

PI_NAMEs: CZEISLER, CHARLES A (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Acute;Adult;Adverse effects;Affect;Age;American;Area Under Curve;Brain;Cardiovascular Diseases;Chronic;Circadian Dysregulation;Circadian Rhythms;Crossover Design;Darkness;Development;Diabetes Mellitus;diabetes risk;Diet;Endocrine disruption;Endocrine Disruptors;epidemiology study;Exhibits;experimental study;Exposure to;Glucose;glucose metabolism;glucose tolerance;Goals;Health;Homeostasis;Hour;Human;Hydrocortisone;impaired glucose tolerance;Impairment;improved;insulin sensitivity;Intervention;intravenous glucose tolerance test;Laboratories;Laboratory Study;Light;Lighting;Link;Lipids;Mass Spectrum Analysis;Measures;Melatonin;Metabolic;Metabolic syndrome;mortality;mortality risk;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Participant;Pathway interactions;Pattern;Periodicity;Plasma;Posture;Prevalence;prospective;Randomized;Recommendation;Reporting;response;Risk;Sampling;sex;Sleep;Sleep Deprivation;Standardization;Temperature;Testing;Toxicant exposure;Triglycerides

PROJECT_TITLE: Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AI

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Powassan virus (POWV) is a tick-borne flavivirus with the potential to emerge as a public health threat in the United States. Viral infection can be associated with severe neurological symptoms, and is periodically lethal. This proposal is focused on the development of a safe, non-replicating vaccine that can be used for prevention of a POWV-associated disease in humans.

PI_NAMEs: HIRSCH, ALEC J (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adjuvant;Antibodies;Antigens;Attenuated Live Virus Vaccine;B-Lymphocytes;Black-legged Tick;Brain;C Type Lectin Receptors;Canada;Cell Communication;Cell Culture Techniques;Code;cohort;Cultured Cells;cytokine;design;Development;Disease;Disease Outbreaks;Dose;emerging pathogen;emerging virus;Encephalitis;Epitopes;Evaluation;Event;experience;Flavivirus;Flavivirus Infections;Formulation;Generations;Good Manufacturing Process;Health;Human;Human Bites;Immune;Immune response;Immunity;immunogenicity;Immunomodulators;Individual;Infection;Ixodes;Ixodidae;Laboratory mice;Lectin Receptors;Mammals;member;Membrane;Meningitis;Modeling;Montana;mouse model;Mus;Neurologic Symptoms;neurotropic virus;neutralizing antibody;North America;novel;novel vaccines;Oregon;pathogenic virus;Pattern recognition receptor;Phenotype;Positioning Attribute;Powassan virus;Prevention;Production;protective efficacy;Proteins;Public Health;Reporting;research clinical testing;response;Risk;Russia;Safety;Sampling;scale up;Science;Serum;Structure;Survival Analysis;System;T cell response;T-Lymphocyte;Testing;tick-borne;Tick-Borne Diseases;tick-borne flavivirus;Ticks;Tissues;Toll-like receptors;United States;Universities;Vaccinated;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine delivery;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Production;Vaccines;vector;vector tick;Viral;Viral Load result;viral transmission;Virion;Virus;Virus Diseases;Virus-like particle;Vulnerable Populations;White-Footed Mouse;Zika Virus

PROJECT_TITLE: Development of a Virus-Like Particle Vaccine for Powassan Virus


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Chicago

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Affecting 50 M worldwide yearly, traumatic brain injury (TBI) is the leading cause of visual dysfunction and vision loss in sports-related injury, and automobile accidents in the United States. Preventing retinal cells from becoming dysfunctional or dying, with the attendant disability, is a major public health necessity. Our objective, to study mesenchymal stem cell-derived extracellular vesicles (EVs) which are functionally engineered to overexpress specific microRNAs for retina-specific protective actions in TBI, fits well with the NEI Strategic Plan’s goals to improve visual health via safe cell-free delivery of therapeutic molecules directly to retinal cells.

PI_NAMEs: ROTH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adjuvant;Affect;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Athletic Injuries;Attenuated;automobile accident;Biology;Blindness;Cell Death;Cell Line;Cells;Cessation of life;clinically relevant;combat;cranium;cytokine;Cytoprotection;Data;Diabetic Retinopathy;disability;Engineering;exosome;experimental study;Exposure to;extracellular vesicles;Eye;Functional disorder;functional mimics;Genes;glial activation;Glutamates;Goals;Health;human disease;human model;Hypoxia;immunoregulation;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Injury;innovation;Interruption;knock-down;Knowledge;Laboratories;Left;Lentivirus Vector;loss of function;Mesenchymal Stem Cells;Methodology;Microglia;MicroRNAs;mild traumatic brain injury;mouse model;Muller's cell;Natural regeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neuronal Dysfunction;novel;overexpression;Parents;Pathway interactions;Play;precision medicine;Precision therapeutics;preconditioning;prevent;Public Health;Publishing;repaired;response;Retina;retinal damage;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Rodent;Rodent Model;Role;Specificity;Sports;stem cells;Strategic Planning;Stress;stroke model;Testing;Therapeutic;transcriptome sequencing;Translating;translational medicine;Trauma;Traumatic Brain Injury;Tropism;United States;Visual;visual dysfunction

PROJECT_TITLE: VRC: Engineered extracellular vesicles for mild TBI-induced retinal injury


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE  Despite decades of research in academia and the pharmaceutical industry, we currently have very few small molecule ligands that can address RNA selectively and elicit useful biological effects. This leaves a tremendous portion of cellular biochemistry and metabolism outside of our control. We are tackling this challenging problem by using computer-assisted drug design to develop novel RNA-targeting chimeras to control RNA stability and RNA splicing during the translation of disease-modifying genes.

PI_NAMEs: WANG, JINGXIN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Academia;Address;Binding;Biochemistry;Biological;Chemicals;Chimera organism;Computer Assisted;Coumarins;design;Disease;Drug Design;Drug Industry;Gene Expression;Gene Proteins;Genes;genetic inhibitor;Genetic Transcription;Goals;individualized medicine;Ligand Binding;Ligands;Metabolism;Methods;Modeling;Modification;mRNA Precursor;novel;Oligonucleotides;Pharmaceutical Chemistry;Process;programs;Property;Protac;Proteins;Research;RNA;RNA Binding;RNA Degradation;RNA Splicing;RNA Stability;RNA Viruses;Safety;scaffold;small molecule;Small RNA;Specificity;Spinal Muscular Atrophy;Technology;Time;tool;Translations;Work;Zika Virus

PROJECT_TITLE: Modulating gene expression by RNA-targeting chimeras


ORG_CITY: RICHMOND

ORG_NAME: VA ST DEPT/ AGRICULTURE & CONSUMER SRVS

ORG_STATE: VA

PHR: Project Narrative Recognizing the need for a more rapid response to naturally occurring pathogen outbreaks and intentional terrorism events, the VDACS Lynchburg RAHL would utilize this partnership to upgrade its microbial pathogen detection and identification infrastructure. Which would not only enable it to be better able to perform routine surveillance assignments with the Vet-LIRN, but also be prepared to participate in larger scale animal/food/drug emergencies requiring enhanced surge capacity.

PI_NAMEs: WALTERS, JESSICA N. (contact)

PROJECT_TITLE: Vet-LIRN, Enhancement of Capacity of Response to Veterinary Microbiological Investigations in the Commonwealth of Virginia.


NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE Deciphering the complex regulatory networks that control cell-fate decisions of embryonic cells is a major objective in the field of development. This includes how developmental cues, such as NODAL and Hippo-signaling pathways, control the acquisition of cell lineages during the specification of the three germ-layers. This knowledge may lead to the discovery of new tools in the battle against birth defects.

PI_NAMEs: ESTARAS, CONCEPCION  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anterior;Binding;Binding Sites;Cell Fate Control;Cell Lineage;Cell Proliferation;Cells;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congenital Abnormality;CRISPR/Cas technology;Cues;Data;Deacetylase;Deposition;Development;developmental disease;Diagnosis;Disease;DNA;dosage;Ectoderm;Embryo;embryo cell;Embryology;Embryonic Development;Endoderm;Enhancers;Epiblast;Epigenetic Process;epigenetic regulation;epigenomics;Equilibrium;Essential Genes;Event;experimental study;EZH2 gene;Gastrula;gastrulation;gene repression;Genes;Genetic;genome sequencing;Germ Layers;Goals;Histones;Homeostasis;Human;Human Development;human embryonic development;human embryonic stem cell;Image;imaging approach;in vivo;in vivo evaluation;Infertility;Knockout Mice;Knowledge;Ligands;Link;Location;Mediating;Mesoderm;Modeling;Molecular;Molecular Target;multiple omics;Mus;Mutagenesis;Neuroectoderm;Neuroectodermal Cell;Newborn Infant;Nodal;Nucleosomes;Pathway interactions;Pattern;Phenotype;pluripotency;Population;prevent;Prevention;Primitive Streaks;Process;recruit;Regulation;Repression;Role;Signal Pathway;Signal Transduction;Site;Specific qualifier value;Spontaneous abortion;System;Testing;Therapeutic;tool;Transcription Factor 3;transcriptomics;Variant

PROJECT_TITLE: The Role of Hippo-Yap1 Signaling in Germ-layer Specification

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunization;Infectious Diseases;Liver Disease;Organ Transplantation;Prevention;Transplantation;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This multicenter clinical trial will examine whether a vaccine (“Triplex”) for a common viral infection (cytomegalovirus [CMV]) will be safe, effective and elicit CMV-specific immunity, and decrease the need for toxic CMV antiviral therapy in liver transplant recipients who are at high risk for CMV infection. If shown to be effective, this vaccine could be used as a way to better prevent CMV infection in transplant recipients and other populations with weakened immune systems who are at risk for CMV infection.

PI_NAMEs: DASGUPTA, SAYAN ;DIAMOND, DON J;FISHER, CYNTHIA E;LIMAYE, ABHIJIT PRAKASH (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acceleration;Address;Allogenic;Anti-viral Therapy;antigen-specific T cells;Antigens;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;Cellular Immunity;Clinical;Clinical assessments;clinical risk;clinically relevant;Color;combinatorial;cost;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Disease;Dose;efficacy evaluation;Evaluation;experience;FDA approved;Flow Cytometry;Future;Goals;Hematopoietic;high risk;Immune;Immune response;Immune system;Immunity;immunogenicity;Immunologic Memory;Immunosuppression;Impairment;improved;Link;liver transplantation;Measurement;Modified Vaccinia Virus Ankara;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;novel;Organ;organ transplant recipient;Outcome;Phase;phase 2 study;Population;Predisposition;prevent;Prevention;Prevention strategy;Preventive;primary outcome;Prophylactic treatment;Protocols documentation;randomized placebo controlled trial;reconstitution;Risk;Safety;seropositive;Solid;Standardization;Surface;T-Lymphocyte;T-Lymphocyte Subsets;Target Populations;Testing;Therapeutic;Toxic effect;transmission process;Transplant Recipients;Vaccination;vaccine efficacy;Vaccines;Valganciclovir;Viral;Viral Load result;Virus Diseases

PROJECT_TITLE: Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant candidates (COLT)


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project narrative Scarring in the lung can occur after inhalation of silica, asbestos and other particles, but no one knows how or why that happens. We believe that non-degradable particles reprogram cells in the lung to produce acid and other factors in a futile attempt to dissolve them, which causes collateral injury and fibrosis in surrounding tissues. The tissue damaging cells have many similarities to osteoclasts, cells that dissolve bone, which are eminently targetable with bisphosphonates and other readily available and FDA approved agents if our theory proves to be correct.

PI_NAMEs: MCCORMACK, FRANCIS XAVIER (contact)

PROJECT_TERMS: Acceleration;Acids;Actins;Address;Alveolar;Alveolar Macrophages;Animals;Asbestos;Attenuated;Automobile Driving;autosome;Biochemical;bisphosphonate;black lung;bone;Bone Marrow;Bone Matrix;Bone Resorption;Calcitonin Receptor;Calcium;calcium phosphate;cathepsin K;Cell Differentiation process;cell injury;Cell Lineage;Cell Physiology;cell transformation;Cells;Clinical;Clinical Trials;Coculture Techniques;Complex;cytokine;Defect;Development;Disease;Enzymes;Epithelium;experimental study;Exposure to;Extracellular Matrix;FDA approved;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Transcription;Giant Cells;Goals;Histologic;Homeostasis;Host Defense;Human;human RNA sequencing;Hydrochloric Acid;Hydroxyapatites;In Vitro;in vivo;Inflammasome;Inhalation;Injury;inorganic phosphate;insight;Lesion;lipid metabolism;Liquid substance;Lung;Lung Diseases;Macrophage;Macrophage Colony-Stimulating Factor;Measures;Mediating;migration;Minerals;Molecular Target;monocyte;mouse model;Mus;Mutation;Mycobacterium tuberculosis;Myelogenous;Myeloid Cells;novel;Occupational;osteoclastogenesis;Osteoclasts;particle;Particulate;Pathogenesis;Pathway interactions;Patients;Pattern;Peptide Hydrolases;pharmacologic;Phospholipid Metabolism;Physiological;Planet Earth;Pneumoconiosis;PPAR gamma;pre-clinical;Predisposition;Prevalence;prevent;Process;Production;programs;Proliferating;protein expression;Proteins;Proton Pump;Pulmonary alveolar microlithiasis;Pulmonary Alveolar Proteinosis;Pulmonary Challenge;Pulmonary Fibrosis;recruit;Reporting;response;Role;Silicon Dioxide;Silicosis;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;sodium-phosphate cotransporter proteins;Specific qualifier value;Stereotyping;Structure of parenchyma of lung;surfactant;Syndrome;tartrate-resistant acid phosphatase;Testing;theories;Tissues;TNFSF11 gene;Transforming Growth Factor beta;Up-Regulation;Zoledronic Acid

PROJECT_TITLE: Novel Mechanisms of Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Disruption of the GDE2 pathway mimics neurodegenerative and synaptic changes observed in Alzheimer's Disease (AD). Proposed studies will use a three-pronged experimental approach employing electrophysiological, behavioral, and molecular techniques to determine how this pathway affects synaptic function and behavior. Outcomes have potential to provide deeper insight into underlying mechanisms of pathologies associated with AD that in the long-term may aid in the design of mechanism-based therapies for AD.

PI_NAMEs: DAUDELIN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Abeta synthesis;Address;Adult;Affect;Age;Age Months;aged;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anxiety;Behavior;Behavioral;beta secretase;Binding;Biochemical;biocytin;Biology;Brain;brain control;brain tissue;Cell Surface Proteins;Cells;Central Nervous System;Cognition;Cognitive;cognitive change;cognitive skill;Collaborations;collaborative environment;comparison control;Confocal Microscopy;cysteine rich protein;Defect;Dementia;Dendritic Spines;Deposition;design;Development;Disease;Electrophysiology (science);Exhibits;experimental study;extracellular;Frequencies;Functional disorder;gain of function;gamma secretase;glycerophosphodiester phosphodiesterase;Glycosylphosphatidylinositols;GPI Membrane Anchors;Grant;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;inhibitor;insight;Integral Membrane Protein;Knowledge;Language;lentivirally transduced;Ligands;Long-Term Depression;Long-Term Potentiation;Longitudinal Studies;Measures;Mediating;member;Membrane;Memory;Mentors;Mentorship;Metalloproteases;Molecular;Molecular Probes;Motor Activity;mouse model;Mus;National Research Service Awards;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neuronal Differentiation;Neurons;neurotoxic;new therapeutic target;novel;Outcome;patch clamp;Pathology;Pathway interactions;Patients;Persons;Phenotype;Physiologic pulse;Play;postsynaptic;preservation;presynaptic;Property;Protein Family;Proteins;receptor;Regulation;Research;Role;Scientist;Series;Short-Term Memory;skills;Structure;Surface;Synapses;synaptic function;Synaptic plasticity;targeted treatment;tau Proteins;teacher;Techniques;Testing;Therapeutic Intervention;Training;Visualization;Walking;WNT Signaling Pathway;Work;Writing

PROJECT_TITLE: Investigating pathways of hippocampal synaptic funtion: potential implications for Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE A substantial proportion of the population maintains stable cognitive function despite the development of Alzheimer’s disease (AD)-related pathology. The neural mechanisms underlying this cognitive resilience are poorly understood, though an understanding of these mechanisms has immense therapeutic potential. The proposed research will investigate the independent and interactive effects of one candidate mechanism – compensatory elevation of dopamine synthesis – and AD-related pathology on memory performance and local functional connectivity using a multi-modal neuroimaging approach in aging.

PI_NAMEs: PARENT, JOURDAN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Age;age effect;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid beta-Protein;Animal Model;Anterior;Attention;Berry;blood oxygen level dependent;Boston;Brain;brain tissue;career;cingulate cortex;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive reserve;cognitive testing;Cohort Studies;college;Communication;Compensation;Development;Disease;Dopamine;dopamine system;experience;Faculty;Functional Magnetic Resonance Imaging;General Hospitals;Genes;Goals;healthy aging;Hippocampus;Human;human subject;Impaired cognition;in vivo;Individual;innovation;insight;interest;Intervention;Link;Maintenance;Massachusetts;Measures;Medial;Memory;Memory impairment;Mentors;Mentorship;Metabolic;Methods;Midbrain structure;Monitor;Motivation;multimodal neuroimaging;neural;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;neuromechanism;Neuromodulator;Neurons;neuropathology;Neuropsychology;neuroregulation;Neurotransmitters;older adult;Parkinson Disease;Pathologic;Pathology;Pattern;Performance;Population;Positron-Emission Tomography;Predisposition;Prefrontal Cortex;preservation;Prevalence;Prevention Research;Process;Proxy;Qualifying;Research;Research Support;resilience;Rest;Rodent Model;Role;Sampling;Senile Plaques;Signal Transduction;Site;statistics;Structure;System;Testing;Therapeutic;tomography;Traction;Training;Universities;Up-Regulation;Work;young adult;Youth

PROJECT_TITLE: The Role of Dopamine in Cognitive Resilience to Alzheimer's Disease Pathology in Healthy Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative This project will enrich our understanding of how visual computation is organized and distributed across neurons and circuits at a critical processing stage, where the breadth of sensory feature encoding is greatly increased. These experiments will establish how synapses and molecules are preferentially recruited to fulfill the requirements of particular visual computations. Computational principles revealed by this study may allow us to predict neuronal function based solely on gene expression data, and will fundamentally improve important technologies, including machine vision and retinal prosthetics.

PI_NAMEs: CURRIER, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Computational, anatomical, and molecular principles of system-wide visual encoding


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Cognitive impairment is a debilitating side-effect of chemotherapy treatment that affects learning, memory, attention, and executive functions in cancer patients. This condition is worse in people who have the APOE4 gene, which is also the strongest genetic risk factor for Alzheimer’s Disease. The experiments in this proposal use a novel mouse model of chemotherapy-treated APOE mice to 1) identify circuit-based mechanisms in the entorhinal cortex underlying cognitive impairment and 2) test whether altering apoE levels can prevent CICI development.

PI_NAMEs: LUO, NANCY  (contact)

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;Aftercare;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Attention;Brain;Brain region;Cancer Patient;Cancer Survivor;cancer therapy;Cerebral cortex;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Cognitive;common treatment;Confocal Microscopy;Cues;Development;Diffuse Lewy Body Disease;Doxorubicin;Electrophysiology (science);entorhinal cortex;Equilibrium;excitatory neuron;executive function;Exhibits;experience;experimental study;Female;Functional disorder;Future;Genes;Genetic Predisposition to Disease;genetic risk factor;Genotype;Glial Fibrillary Acidic Protein;Glutamates;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;Impairment;Individual;inhibitory neuron;insight;Interneurons;Label;Learning;Link;Malignant Breast Neoplasm;Measures;Memory;Memory impairment;Modeling;Morphology;mouse model;Mus;Myoepithelial cell;Neurofibrillary Tangles;Neurons;novel;Outcome;outcome prediction;Parvalbumins;Pathologic;Patients;Persons;Play;Population;postsynaptic;Predisposition;preservation;presynaptic;Prevalence;prevent;processing speed;Property;Protein Isoforms;Pyramidal Cells;Reporting;Risk;Role;side effect;spatial memory;Stress;Synapses;Testing;Therapeutic;tool;Transgenic Mice;Viral;Work

PROJECT_TITLE: Characterizing Entorhinal Cortex Circuit Dysfunction in an APOE Mouse Model of Chemotherapy-Induced Cognitive Impairment


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Head and Spine Injury

ORG_DEPT: BIOLOGY

PHR: Project Narrative This study will greatly advance our fundamental understanding of how the brain controls movement and how brain areas interact to make simple choices. Uncovering the principles of operation in the motor system is likely to inform treatments for motor disorders such as Parkinson’s and enable better brain-machine interfaces for use by paralyzed patients. Understanding how brain areas communicate is vital for advancing treatment for stroke and traumatic brain injury, which often disrupt these connections.

PI_NAMEs: KAUFMAN, MATTHEW TYLER (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Algorithms;Animals;Area;Behavior;Biological;Biology;Brain;brain control;brain machine interface;Calcium;Categories;cell type;Communication;Complex;Computer Analysis;Data;Decision Making;dimension reduction;Dimensions;Disease;dynamic system;Electrophysiology (science);Engineering;Exhibits;fighting;flexibility;Foundations;Generations;Genetic;Goals;Head;Image;improved;Individual;information processing;insight;Joystick;Knowledge;Learning;Left;Link;Machine Learning;Mammals;Maps;Mathematics;Monkeys;Motor;motor control;Motor Cortex;motor disorder;Motor output;mouse model;Movement;Mus;Muscle;neural;neural circuit;neuromechanism;Neurons;Neurophysiology - biologic function;Noise;novel;operation;optogenetics;Output;Paralysed;Parietal;Parkinson Disease;Pathway interactions;Patients;Pattern;Population;Process;Recording of previous events;Signal Transduction;Sorting;Stimulus;Stroke;stroke therapy;Synapses;System;Systems Analysis;Techniques;Testing;theories;Time;Tissues;tool;Traumatic Brain Injury;two-photon;Variant;Visual;visual motor;Work

PROJECT_TITLE: Mapping neural ensemble computations to biological circuitry in motor control and decision making - Resubmission - 1

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Intracerebral hemorrhage (ICH) is a severely debilitating cerebrovascular disease, which affects over 70,000 patients per year in the U.S., and is responsible for over half of stroke-related disability worldwide. So far, the diagnosis, surveillance, and prediction of outcome in intracerebral hemorrhage have mainly relied on visual and subjective assessment of head CT scans. Computerized assessment of medical images and machine learning algorithms can extract hidden features from CT scans and provide innovative tools for accurate outcome prediction and personalized treatment decisions in patients with hemorrhagic stroke.

PI_NAMEs: PAYABVASH, SEYEDMEHDI  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Admission activity;Affect;Age;Atlases;automated analysis;automated assessment;Award;bioimaging;Biologic Characteristic;Biological;Biological Markers;blood-brain barrier disruption;Brain;Brain hemorrhage;Brain Injuries;Brain scan;career;career development;Caring;Cellularity;Cerebral hemisphere hemorrhage;Cerebrovascular Disorders;Cerebrum;Characteristics;Clinical;clinical risk;Clinical Trials;Clinical/Radiologic;college;Computer Vision Systems;computerized;cytotoxic;Data;data archive;deep neural network;density;Deterioration;Development Plans;Diagnosis;Diagnostic;disability;Edema;effective therapy;evidence base;feature extraction;feature selection;follow-up;functional gain;functional independence;Funding;Future;Genomics;Goals;Grant;Growth;Head;Healthcare;Hematoma;Hemoglobin;Hemorrhage;Heterogeneity;High Performance Computing;Hour;Human;Image;Image Analysis;image processing;imaging biomarker;improved;Inflammatory;Infrastructure;innovation;Institution;Knowledge;Lead;Lesion;Linear Models;Location;London;Machine Learning;machine learning algorithm;machine learning model;Magnetic Resonance Imaging;Mathematics;Medical Imaging;Mentored Patient-Oriented Research Career Development Award;Mentorship;metabolomics;modifiable risk;Nature;Necrosis;neuroimaging;neuroimaging marker;Neurologic;Neurologic Deficit;Neurologic Symptoms;Neurosciences;new therapeutic target;novel;online repository;Outcome;outcome prediction;Patient Care;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Physicians;Positioning Attribute;precision medicine;Process;professor;prognostic;Prognostic Factor;prognostication;Proteomics;quantitative imaging;Radiology Specialty;radiomics;Reading;Registries;Research;research and development;Research Personnel;Resources;Risk;Risk Factors;risk stratification;Scientist;Services;Severities;Shapes;Signal Transduction;skills;Statistical Data Interpretation;statistics;Stroke;Symptoms;Techniques;Texture;Tissues;tool;Training;treatment optimization;United States National Institutes of Health;Universities;Visual;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Radiomics signatures and patient outcomes in intracerebral hemorrhage


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: BLOOMINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: PROJECT NARRATIVE Sensory perception is vital for hand movement, and learning in both sensory and motor systems of the brain helps keep hand control smooth and accurate. Interactions between sensory and motor systems are not well understood, and the proposed research will systematically test a new framework for understanding sensory-motor interaction in hand control. Findings may enable advances in basic and clinical research areas that depend on mechanistic knowledge of sensorimotor function.

PI_NAMEs: BLOCK, HANNAH JUSTINE (contact)

PROJECT_TERMS: Address;Affect;Anterior;Applied Research;Area;Basic Science;Behavior;Brain;Brain region;Cephalic;Cerebellum;Clinical Research;Complex;Cues;Data;Environment;Evolution;experience;experimental study;field study;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Hand;Homologous Gene;Human;innovation;Joints;Knowledge;Laboratory Research;Learning;Limb structure;Literature;Lobule;Magnetism;Measures;Modality;Modernization;Monkeys;Motor;motor behavior;motor control;Motor Cortex;motor learning;Movement;multisensory;Muscle;neural;neuroimaging;Neurons;Neurosciences;Parietal;Participant;Perception;Perceptual learning;Positioning Attribute;Process;Proprioception;Research;response;Rest;Role;Sensorimotor functions;Sensory;sensory integration;Sensory Process;sensory stimulus;Shapes;Site;Somatosensory Cortex;Space Perception;System;Testing;Transcranial magnetic stimulation;Translating;Upper Extremity;Vision;Visual;Work

PROJECT_TITLE: Neural basis of sensory and motor learning

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Currently, we know little about how an intact brain plans for shoulder or combined shoulder and hand movements. Therefore, we propose to investigate the cortical communication and the brainstem’s activity during motor preparation for hand opening, arm lifting, and hand opening while arm lifting against various shoulder loads. Results are expected to establish the cortical circuits for various motor tasks, and identify the structure and cortical activity affecting the brainstem during the preparation of specific limb movements in an intact nervous system.

PI_NAMEs: YAO, JUN  (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Anatomy;Area;arm;Basic Science;Brain;Brain Injuries;Brain Stem;Bypass;Central Nervous System;Communication;Contralateral;Corticospinal Tracts;Distal;Electroencephalography;Electromyography;Ensure;Experimental Designs;Extensor;Fingers;Flexor;Foundations;Future;Hand;hemiparetic stroke;Human;Individual;Investigation;Ipsilateral;joint mobilization;Joints;Knowledge;Lifting;limb movement;Motor;Motor Cortex;motor deficit;motor disorder;Motor Pathways;Movement;Muscle;National Institute of Neurological Disorders and Stroke;nerve supply;Nervous System;Neuroanatomy;Neurons;neuropathology;Parkinson Disease;Participant;Pathologic;Pathway interactions;Pattern;Phylogenetic Analysis;Preparation;Protocols documentation;Reaction Time;recruit;Reporting;Resources;Reticular Formation;Role;Shoulder;Signal Transduction;sound;Specificity;Spinal;Spinal Cord;Startle Reaction;Stroke;Structure;Testing;Time;Upper Extremity;Work;Wrist

PROJECT_TITLE: The role of the cortex and brainstem in motor preparation for proximal and distal upper extremity movements


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE The rates of severe maternal morbidity (SMM) and maternal mortality (MM) have tripled in the U.S. since 1993, with the burden disproportionately falling on Black and Hispanic women. To address this maternal health crisis and growing inequity, states are increasingly turning to quality care collaboratives (QCCs) to disseminate quality improvement (QI) toolkits that are designed to improve maternal care processes and maternal health. We will combine first-of-its-kind QCC survey data with existing public data sources to evaluate the effects of QCCs and their QI toolkits on maternal care processes (cesarean births overall, and nulliparous singleton term vertex cesarean births) and maternal health outcomes (SMM and MM), with a particular focus on the effects among Black and Hispanic women.

PI_NAMEs: ANDREW, MEGAN  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Birth;Black race;black women;Caring;Cause of Death;Cesarean section;Characteristics;Collaborations;compare effectiveness;Country;Data;Data Set;Data Sources;Databases;design;Diagnosis;Disparity;disparity reduction;Economic Conditions;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;experience;falls;Foundations;Geography;Health;Health Personnel;health training;Healthcare;Hispanic;Hispanic Women;Hospitals;implicit bias;improved;Income;Inequity;Infrastructure;Inpatients;insight;Institutional Racism;Location;Maternal Health;Maternal Mortality;Methods;Not Hispanic or Latino;novel;Nulliparity;operation;Outcome;people of color;Persons;Placebos;Policies;Population;Pregnancy;Procedures;Process;Public Health;Quality of Care;Race;racial disparity;racial health disparity;racial population;Research;Resources;severe maternal morbidity;Shapes;Social Conditions;social health determinants;Structure;Surveys;Testing;trend;Vital Statistics;White Women;Woman;Work

PROJECT_TITLE: The Impacts of State Quality Care Collaboratives on Maternal Health Disparities by Race/Ethnicity

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TULSA

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

ORG_STATE: OK

PHR: Project Narrative American Indians (AIs) have limited access to healthy food and a high prevalence of diet-related diseases. This study will implement a tribal community supported agriculture program in which AI adults receive a weekly box of local fresh fruits and vegetables along with culturally tailored nutrition and cooking education. The program’s effect on diet and health outcomes and it’s cost-effectiveness will be evaluated, and study processes and findings will be broadly disseminated to support tribes in improving diet and health.

PI_NAMEs: JERNIGAN, VALARIE BLUE BIRD (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Adult;aged;Agriculture;American Indian community;American Indian Population;American Indians;Area;Birds;blood lipid;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolism;Centers for Disease Control and Prevention (U.S.);Child;Chronic Disease;Collaborations;Communities;community based participatory research;Congresses;Control Groups;cooking;cost;cost effectiveness;Costs and Benefits;Dependence;design;Diabetes Mellitus;Diastolic blood pressure;Diet;Disease;Disparity;disparity elimination;economic evaluation;Education;efficacy testing;Employee;evidence base;experience;Farm;fast food;Food;Food Access;food insecurity;Food production;Food Supply;fruits and vegetables;Funding;General Population;Glycosylated hemoglobin A;Government;group intervention;Health;health care service utilization;health disparity;health economics;Health Food;health related quality of life;Health Status;High Prevalence;Household;Hypertension;improved;Indian reservation;Indigenous;Individual;Institute of Medicine (U.S.);Intake;Intervention;Knowledge;Life;Marketing;Mediating;Methods;Mission;Morbidity - disease rate;mortality;Multimedia;National Institute on Minority Health and Health Disparities;nutrition;nutrition education;Obesity;Oklahoma;Online Systems;Osage;Outcome;Overweight;Participant;Persons;Policies;Population;prevent;Prevention;primary outcome;Process;programs;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reduce health disparities;Research;research study;Reservations;Risk Factors;Rural;Savings;Schools;secondary outcome;Source;System;Testing;tribal community;tribal Nation;Tribes;Unhealthy Diet;United States;United States Department of Agriculture;urban Native American;Waiting Lists

PROJECT_TITLE: Osage Community Supported Agriculture Study (OCSA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(55)]


NIH_SPENDING_CATS: Neurosciences

PHR: Project Narrative Current theories of how cerebellar cortical circuitry optimizes motor, cognitive, and emotional performance rely on two core assumptions: 1) circuit connectivity is rigidly conserved and stereotypical across cells and regions; and 2) Purkinje cell (PC) dendrites act as one homogeneous unit to process information. Challenging both assumptions, this proposal describes a PC subpopulation with segregated dendritic compartments that receive distinct inputs and exhibit heterogeneous signaling that influences PC computations and output. The influence of dendrite morphology–also incorrectly assumed to be stereotypical– on function introduces a structure- function relationship that substantially updates current theories of cerebellar function and provides a vital context for cerebellar dysfunction in diseases such as ataxia, essential tremor, and autism spectrum disorder.

PI_NAMEs: BUSCH, SILAS EDWARD (contact)

PROJECT_TERMS: Affect;Anatomy;Animals;Architecture;Ataxia;autism spectrum disorder;awake;Axon;Calcium;Calcium Signaling;Cell Physiology;cell type;Cells;Cellular Morphology;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Characteristics;Cognitive;Complex;confocal imaging;Data Analyses;Dendrites;Dependence;design;Development;Disease;Educational process of instructing;Electrophysiology (science);Elements;Emotional;Essential Tremor;Event;Exhibits;experimental study;Fiber;Frequencies;Functional disorder;Goals;granule cell;Heterogeneity;Image;In Vitro;in vivo;Individual;Inferior;insight;Knowledge;Learning;Measurable;Mediating;Methods;Modality;model of autism spectrum disorder;Morphology;Motor;mouse model;multimodality;multisensory;Mus;nerve supply;network models;neural network;neuronal cell body;Neurons;novel;Olives - dietary;operation;Output;overexpression;patch clamp;Pathway interactions;Pattern;Performance;Physiological;Physiology;Picrotoxin;Preparation;Presynaptic Terminals;Process;Purkinje Cells;Research;Research Personnel;response;Rest;Role;Running;segregation;Sensory;sensory input;Severities;Signal Transduction;Source;Structure-Activity Relationship;System;targeted treatment;Techniques;Testing;theories;Tracer;Training;Trees;two-photon;Update;Work

PROJECT_TITLE: Dendritic morphology, patterns of input, and calcium signal heterogeneity in a novel subpopulation of cerebellar Purkinje cells


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NARRATIVE Axonal degeneration underlies many debilitating diseases including HSPs, ALS and Alzheimer's disease. This proposed study seeks to delineate the role of glial cells and the neuron-glia crosstalk in the pathogenesis of SPG3A, the most early-onset form of HSP. The long term goal of the study is to identify targets and therapeutics to rescue axonal and synaptic degeneration in HSP and other diseases that involve axonopathy.

PI_NAMEs: LI, XUE-JUN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Adipose tissue;Agreement;Alzheimer's Disease;Astrocytes;ATP binding cassette transporter 1;Axon;axonal degeneration;Axonal Transport;axonopathy;Brain;Brain Stem;Caenorhabditis elegans;Cells;Cerebral cortex;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Coculture Techniques;Corticospinal Tracts;Cultured Cells;Data;Defect;Development;Disease;Drosophila genus;early onset;effective therapy;Electrophysiology (science);Endoplasmic Reticulum;Exhibits;experimental study;Fat Body;fly;Genes;Goals;Hereditary Spastic Paraplegia;Histologic;human pluripotent stem cell;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Interruption;Intestines;Knock-in;Knockout Mice;Length;lipid metabolism;Lipids;Lipoproteins;locomotor deficit;Mediating;Modeling;Morphogenesis;Morphology;Motor Cortex;Motor Neurons;Movement;Muscle;Muscle Spasticity;Muscle Weakness;Mutation;Nerve;Nerve Degeneration;Nervous System Disorder;neurogenetics;Neuroglia;Neurons;new therapeutic target;novel;Pathogenesis;Pathologic Processes;Pathology;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Play;Proteins;Rodent Model;Role;Signal Transduction;Source;spasticity;Spinal;Spinal Cord;stem cell model;Synapses;Testing;Therapeutic;Therapeutic Intervention;trafficking;transmission process;Zebrafish

PROJECT_TITLE: Uncover the role of glia-neuron crosstalk in hereditary spastic paraplegias

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE This research engages a unique national community health center practice “laboratory” caring for more than 2.6 million patients to examine the dramatic longitudinal effects of the COVID-19 pandemic on primary health care equity. Time-series analyses will show the evolution of ongoing practice innovations such as telehealth and targeted outreach and their effect on patient outcomes and workforce sustainability. Comparative case studies will identify and characterize transportable practice innovations to advance equity of care for health disparity populations.

PI_NAMEs: COOK, NICOLE JILL;STANGE, KURT C (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: acute care;Adoption;African American;Back;birth control;Budgets;Caring;Case Study;Chronic Care;Chronic Disease;Clinic;Communities;Community Health Networks;comparative;Computerized Medical Record;cost;Country;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Decision Making;Depression screen;Disadvantaged;Disasters;disparity reduction;Equitable healthcare;Equity;Evolution;experimental study;Financial Hardship;follow-up;functional status;Health;health care delivery;health care disparity;health disparity;health disparity populations;health equity;Health Expenditures;health inequalities;Healthcare;Healthcare Systems;Hour;Human;improved;Information Technology;innovation;insight;Insurance;Intervention;Interview;Knowledge;Laboratories;Language;Latino;long term consequences of COVID-19;Long-Term Effects;low socioeconomic status;Measures;Medicaid;Movement;multiple chronic conditions;Natural Disasters;Natural experiment;Neighborhood Health Center;novel;Outcome;Outpatients;outreach;pandemic disease;pandemic impact;Patient Care;patient registry;Patient-Focused Outcomes;Patients;personalized care;Persons;Policies;Population;population health;Populations at Risk;practice-based research network;Prenatal care;Preventive service;Primary Care;primary care practice;Primary Health Care;Process;Provider;Public Health;Qualifying;Quality of Care;Refugees;remote visit;Reporting;reproductive;Research;response;Rural Health Centers;safety net;Sampling;Seasonal Variations;secondary analysis;service delivery;social;Social Change;stay-at-home order;Subgroup;Surveys;telehealth;Telephone;Time Series Analysis;tool;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Long-Term Effects of COVID-19-induced Health Care Delivery Changes on Patient & Workforce Processes & Outcomes in Safety Net Practices Caring for Health Disparity Populations


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Sleep Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The brain present and proposed research will establish a new and theoretically-sound property of neuronal activity that allows the to consciously detect and respond o sensory stimuli. Identifying the conditions in which this property is will help us reliably determine the likelihood of conscious perception in patients undergoing anesthesia in those suffering from brain injury. t

PI_NAMEs: LUCAS, TIMOTHY H;PROEKT, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Affect;Anesthesia procedures;Anesthesiology;Arousal;Auditory;auditory stimulus;Auditory Threshold;awake;Awareness;Bayesian Modeling;Binding;Brain;Brain Injuries;clinically significant;Complex;Conscious;Data;Data Set;Dedications;Detection;Diagnosis;Drowsiness;dynamic system;Electric Stimulation;Electrical Stimulation of the Brain;Electrocorticogram;Electrodes;Epilepsy;Frequencies;General Anesthesia;General anesthetic drugs;High Frequency Oscillation;Human;human subject;Implant;inattention;insight;Intuition;Ketamine;Link;Masks;Mathematics;Measures;millisecond;Monitor;Neurology;Neurons;neurophysiology;Neurosciences;Noise;nonhuman primate;novel;Operative Surgical Procedures;Patients;Pattern;Perception;pharmacologic;Phase;Physiologic pulse;Polysomnography;predicting response;Probability;Property;Propofol;Psychometrics;Psychophysics;Research;response;Role;Sedation procedure;Sensory;sensory stimulus;Signal Transduction;Sleep;Sleep Deprivation;Sleep Stages;Sleep Wake Cycle;Slow-Wave Sleep;sound;spatiotemporal;Speech;Stimulus;Techniques;Technology;Testing;theories;Time;Titrations;Training;Unconscious State;Wakefulness

PROJECT_TITLE: The role of dynamical criticality in human perception

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Many infants are born with excessive fluid in their brains, known as hydrocephalus. Our understanding of hydrocephalus is incomplete, which makes designing treatments much more difficult. We use frogs to study the genes causing hydrocephalus to understand the disease process and design new treatments.

PI_NAMEs: DENIZ, ENGIN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;absorption;Affect;Animal Model;Binding;Biological Models;Birth;Brain;Candidate Disease Gene;Cells;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid flow;Childhood;Chromatin Remodeling Factor;Cilia;cilium biogenesis;cilium motility;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Congenital Abnormality;Congenital Hydrocephalus;CRISPR/Cas technology;Defect;design;Development;Disease;Embryo;Failure;Fluids and Secretions;Future;Genes;Genetic;Genetic study;Genomics;Goals;Human;Human Genetics;human model;Hydrocephalus;Image;imaging modality;imaging platform;Immunohistochemistry;improved;In Situ Hybridization;Infant;Lead;Legal patent;Liquid substance;Medical;Membrane;Modality;Morbidity - disease rate;Morphology;mortality;Motility;mutant;Mutation;nerve stem cell;neural;neural patterning;neurodevelopment;neuroepithelium;neurogenesis;novel;novel strategies;Obstruction;Obstructive Hydrocephalus;Operative Surgical Procedures;Optical Coherence Tomography;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Process;Proliferating;Protein Secretion;Rana;receptor;Regulation;Role;SHH gene;Signal Pathway;Signal Transduction;SMARCA4 gene;SMARCC1 gene;stem cell biology;stem cell fate;Stenosis;System;Tadpoles;Testing;therapy design;Thinness;Time;transcriptomic profiling;ubiquitin-protein ligase;Ventricular;ventricular system;Visualization;Work;Xenopus

PROJECT_TITLE: Analysis of Congenital Hydrocephalus Genes in Xenopus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The ever-changing landscape of genetic research requires the training of scientists in state-of-the-art genetics and genomics technologies to answer fundamental mechanistic biological questions that inform us about human biology and disease. The University of Michigan (UM) Predoctoral Genetics Training Program will consist of: (1) a diverse cohort of Ph.D. trainees from six basic science departments spanning the UM Medical School and College of Literature, Sciences, and the Arts campuses; (2) productive faculty with diverse genetics research interests; and (3) a comprehensive curriculum in modern genetics. Here, we present our plan to train the next generation of genetics professionals through: (a) small-group learning experiences; (b) faculty led and peer-to- peer discussions; (c) training-grant specific activities that stress both the ethical conduct of science and critical importance of conducting rigorous and reproducible science; and (d) data-driven evaluation, outcomes, mentoring, and career development programs.

PI_NAMEs: MORAN, JOHN V. (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Genetic;Michigan;pre-doctoral;Training

PROJECT_TITLE: Michigan Predoctoral Training in Genetics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Growing attention has focused on the postpartum period as an important window to address maternal mortality disparities as half of pregnancy-related deaths occur postpartum, and Black and Latina women's excess burden of mortality and morbidity continues during this period. Black and Latina women experience more postpartum complications, ED visits, and postpartum readmissions than do White women. Our mixed method study uses an ecosocial framework to better identify Black and Latina women most at risk for poor outcomes following childbirth, the problems they experience, and to adapt an evidence-based intervention that aims to improve quality of postpartum care for high risk women.

PI_NAMEs: HOWELL, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Attention;Behavioral;Black race;black women;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular system;care seeking;Caring;Case Management;Childbirth;Chronic;Chronic Disease;Clinical;clinical risk;cohort;Communities;Complication;Depression screen;design;Diabetes Mellitus;Disparity;Education;Educational Intervention;Emergency department visit;Equity;ethnic disparity;evidence base;Evidence based intervention;experience;follow-up;Gestational Diabetes;Goals;Health;health disparity;Heart failure;high risk;High Risk Woman;hospital readmission;Hospitals;Hypertension;implementation trial;improved;Individual;Intervention;intervention refinement;Intervention Trial;late life;Latina;Latina Population;Lead;Life;Lung;Maternal complication;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;Measures;Medical;Methods;Morbidity - disease rate;mortality;mortality disparity;Mothers;Neighborhoods;Outcome;Pilot Projects;post pregnancy;postpartum care;postpartum complications;postpartum health;postpartum morbidity;Postpartum Period;predictive modeling;Pregnancy;pregnancy related death;pregnant;prevent;primary outcome;Procedures;Pulmonary Edema;Qualitative Methods;Quality of Care;racial disparity;research study;Risk;Risk Factors;risk prediction model;scale up;severe maternal morbidity;Social Environment;sociodemographics;Visit;White Women;Woman;women of color;Women's mortality

PROJECT_TITLE: Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Regenerative Medicine;Rehabilitation;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: RELEVANCE TO PUBLIC HEALTH Hematopoietic cell transplantation (HCT) is a widely used treatment for hematologic cancers; however, it can accelerate biological aging in recipients by up to 15 years and many survivors experience long-term symptoms that resemble an accelerated aging phenotype. This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in HCT survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

PI_NAMEs: RENTSCHER, KELLY E (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;Address;Adopted;Adult;Aftercare;Age;age acceleration;age related;aged;Aging;aging mechanism;aging process;Attention;behavior observation;behavior prediction;Behavioral;Behavioral Research;biobehavior;Biological;Biological Aging;Biological Testing;Bite;Blood specimen;Buffers;Cancer Survivorship;Cell Aging;cell growth;Cellular Stress;Characteristics;Clinical;Cognitive;collaborative environment;Conflict (Psychology);Data;design;Dimensions;disability;Disease Progression;DNA Damage;DNA Methylation;Elements;Emotional;epigenetic clock;experience;Faculty;Family;Family member;Fatigue;frailty;Friends;functional decline;functional genomics;Funding;Gene Expression;Gene Expression Profiling;genome-wide;Genomics;Goals;Health;Health Psychology;healthspan;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;improved;in vivo;Individual;Inflammation;innovation;Intervention;K-Series Research Career Programs;Knowledge;Late Effects;Length;Link;Mediator;Memory;men;Mentorship;middle age;Muscle Weakness;Occupational;Oxidative Stress;Pain;Participant;Phenotype;Population;premature;primary caregiver;Process;prospective;protective factors;Provider;psychologic;Psychosocial Stress;Public Health;Quality of life;Recovery;reduce symptoms;Regimen;Reporting;Research;Resources;Rest;Scientist;Sex Differences;social;Social Functioning;Social Identification;social influence;Social Interaction;Social Processes;social relationships;Social support;sound;Source;Spouse Caregiver;Spouses;stem cell proliferation;Stress;Survival Rate;Survivors;Symptoms;telomere;Testing;Time;tool;Training;transcriptome sequencing;Transplant Recipients;transplant survivor;Transplantation Conditioning;Woman;Work

PROJECT_TITLE: Accelerated biological and phenotypic aging in hematopoietic cell transplant survivors: Social support as a protective factor

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic and while extensive research over the past year have offered some clues about the strategies that SARS-CoV-2 uses to disarm the host immune responses, there remain gaps in our understanding of the mechanisms used by this virus to subvert host immune responses. The goal of this proposal is to investigate the molecular mechanism by which SARS-CoV-2 NSP14 protein inhibits host translation and down-regulates MHC-I antigen presentation to escape the host immune response. This study has the potential to improve our knowledge of SARS-CoV-2 virus-host interaction, allow new insight into mechanisms governing COVID-19 pathogenesis and viral immune evasion, as well as to provide additional therapeutic targets for antiviral development.

PI_NAMEs: HSU, CHUN CHIEH  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Advisory Committees;Affect;Anti-viral Agents;Anti-viral Response;Antigen Presentation;Antigen Presentation Pathway;antiviral drug development;antiviral immunity;Bioinformatics;Biology;blocking factor;career;CD8-Positive T-Lymphocytes;Cell surface;Cellular Immunity;Cessation of life;Communicable Diseases;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 therapeutics;cytotoxic CD8 T cells;Data;design;Detection;Development;effective therapy;Enzymes;Etiology;Genes;global health;Goals;Grant;Guanine;Guanosine;Head;Health;Histocompatibility Antigens Class I;Immune Evasion;Immune response;Immunobiology;Immunologic Surveillance;Immunology;improved;In Vitro;Infection;Innate Immune Response;insight;interest;interferon antagonist;Interferon Type I;Interferons;Knowledge;Laboratory Research;Major Histocompatibility Complex;Manuscripts;Mediating;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;mRNA Stability;mRNA Translation;Nonstructural Protein;novel vaccines;pathogenic virus;Play;Positioning Attribute;posttranscriptional;prevent;Protein Biosynthesis;Proteins;Publications;Publishing;Research;Research Personnel;response;RNA;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 pathogenesis;skills;Surface;System;T cell response;T-Lymphocyte;therapeutic target;Training;Translational Regulation;Translational Repression;Translations;Viral;virology;Virus;Virus Diseases;virus host interaction

PROJECT_TITLE: Understanding the Molecular Basis of Translation Inhibition by SARS-CoV-2 NSP14 and its Role in SARS-CoV-2 Immune Evasion

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Tourette Syndrome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Children with Tourette syndrome (TS) follow varying clinical courses, as some will experience substantial improvement over the course of adolescence while others will continue to experience significant impairment. Understanding the brain and cognitive features that mediate or predict different outcomes could revolutionize prognosis and treatment. This project will study children with and without TS over time, during the key ages of 10 to 14 years, to (1) investigate how brain and cognitive markers of TS develop over adolescence and relate to changes in symptom severity, and (2) make predictions about future symptom severity for individual children.

PI_NAMEs: GREENE, DEANNA JACQUELYN (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 12 year old;7 year old;Adolescence;Adult;Age;aggressive therapy;Brain;brain control;Brain imaging;Brain region;brain volume;caudate nucleus;Child;Chronic;Classification;Clinical;Clinical Data;Cognitive;cognitive ability;cognitive control;cognitive function;Complex;Data;Data Set;Development;Diagnosis;Diagnostic;epidemiologic data;epidemiology study;experience;Future;Gilles de la Tourette syndrome;gray matter;Impairment;improved;Individual;insight;Intervention;Investigation;Life;Literature;longitudinal design;Longitudinal Studies;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measures;Mediating;Methods;Modeling;Motor;Motor Tics;Movement;multidimensional data;multimodal data;multimodality;Neurobiology;Neurodevelopmental Disorder;Noise;novel;Outcome;Patients;Pattern;predict clinical outcome;Prognosis;Puberty;Public Health;putamen;Quality of life;Recommendation;Research;Rest;Severities;Site;symptomatic improvement;Symptoms;Testing;Thalamic structure;Tic disorder;Time;translational applications;Treatment Protocols;United States National Institutes of Health;Universities;Validation;verbal;Vocal Tics;Washington;white matter

PROJECT_TITLE: Longitudinal Study of Brain Imaging and Cognitive Markers of Tourette Syndrome in Children

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Liver Disease;Lung;Lymphatic Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: The evolution of metastasis in colorectal cancer is poorly understood. Fundamental questions regarding the role of lymph node metastases in systemic progression, and the time point of divergence between primary tumor and distant metastases await resolution. Here, we will apply novel genetic approaches to study the evolutionary history of colorectal cancer metastasis in human patients.

PI_NAMEs: NAXEROVA, KAMILA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Anatomy;anti-cancer research;Belief;Body part;cancer cell;Cancer Patient;capillary bed;care providers;Cause of Death;Cells;Circulation;Clinic;Clinical;clinical application;clinically relevant;Clonal Evolution;cohort;Collaborations;Colon;Colorectal Cancer;colorectal cancer metastasis;cost effective;Data;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Distant;Distant Metastasis;draining lymph node;Event;Evolution;exome sequencing;Extravasation;Fingerprint;gastrointestinal;Gastrointestinal tract structure;genetic approach;Genotype;Growth;Hospitals;Human;improved;insertion/deletion mutation;insight;Investigation;Liver;Lung;lymph nodes;Lymphatic;Lymphatic Metastasis;Lymphovascular;Malignant Neoplasms;metastatic colorectal;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methodology;Methods;migration;Molecular;Neoplasm Metastasis;neoplastic cell;novel;Organ;Outcome;patient subsets;Patients;Phylogenetic Analysis;prevent;Primary Neoplasm;Process;Random Allocation;reconstruction;Recording of previous events;Resected;Resolution;risk stratification;Role;Sampling;Site;Source;Specimen;Systemic disease;Testing;Time;Tissues;Travel;tumor;tumor progression;Untranslated RNA;Venous

PROJECT_TITLE: Illuminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applications


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Cryptosporidiosis is an enteric protozoal infection that is a leading contributor to child morbidity, mortality, and growth impairment worldwide. There is no vaccine for this parasite, and the only available drug, nitazoxanide, lacks rigorous controlled trials in South Asian children under one. This randomized placebo-controlled trial will test efficacy of nitazoxanide to treat both diarrheal and non-diarrheal Cryptosporidium infection in children 6 to 12 months in Bangladesh, and evaluate treatment’s effect on child growth.

PI_NAMEs: KORPE, POONUM S. (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: 5 year old;Adverse event;Aftercare;Age;Age Months;aged;Area;Asia;Bangladesh;Cessation of life;Child;Clinical;Cognitive deficits;cohort;Collaborations;Communicable Diseases;Communities;Complete Blood Count;Cryptosporidiosis;Cryptosporidium;Diarrhea;diarrheal disease;Disease;Double-Blind Method;double-blind placebo controlled trial;effective intervention;effective therapy;Effectiveness;efficacy evaluation;efficacy testing;Enrollment;Enteral;FDA approved;Feces;Functional disorder;Growth;Height;Impairment;improved;Incidence;Individual;Infant;Infection;Infection prevention;innovation;international center;Lactulose;Life;Liver Function Tests;long-term sequelae;Malnutrition;Mannitol;Monitor;Morbidity - disease rate;mortality;nitazoxanide;Nutritional;Oocysts;Oral;Parasites;Participant;patient population;Pharmaceutical Preparations;Pharmacotherapy;Placebos;Population;Protozoa;Protozoan Infections;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Renal function;Research;Resolution;response;Safety;Sanitation;Shoulder;Siblings;Slum;South Asian;standard of care;symptom treatment;Testing;Time;treatment effect;Treatment Efficacy;Universities;Urine;Vaccines;Weight;Work

PROJECT_TITLE: Randomized Control Trial of Nitazoxanide for the Treatment of Cryptosporidium Infection in Malnourished Children in Bangladesh


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal disease throughout regions of the world were basic sanitation and clean water remain in limited supply. These infections have also emerged repeatedly in the United States, often in the form of large outbreaks despite robust sanitation. ETEC is the most common cause of diarrheal illness of soldiers deployed to developing regions of the world where these infections are highly endemic. Both nonimmune children living in these areas and returning veterans frequently experience symptoms that linger long after the diarrheal illness is gone. Many features of the acute illness, that may be severe and indistinguishable from cholera, as well as the subsequent illnesses that persist after the diarrhea has resolved still remain very poorly understood. Understanding how ETEC interact with the intestine and the changes in the intestinal lining caused by these infections could speed the development of treatment or prevention strategies.

PI_NAMEs: FLECKENSTEIN, JAMES MICHAEL (contact)

PROJECT_TERMS: Acute;Adhesions;Animals;Antibodies;apical membrane;Architecture;Archives;Area;Bacteria;Bacterial Adhesins;Bacterial Adhesion;Bacterial Toxins;Bangladesh;Binding;Biological Assay;Biopsy;Carcinoembryonic Antigen;carcinoembryonic antigen-related cell adhesion molecules;Cause of Death;CEACAM1;CEACAM5 gene;CEACAM7 gene;Cell Adhesion;Cell Adhesion Molecules;Cells;Child;Cholera;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Data;Dehydration;design;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;enterotoxigenic Escherichia coli;Enterotoxins;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli heat-labile toxin;Escherichia coli Infections;Escherichia coli Vaccines;experience;Family;Genetic Engineering;Genetic Transcription;Growth;gut colonization;Human;Impaired cognition;In Vitro;in vivo;Individual;Infection;Infection prevention;insight;intestinal epithelium;Intestines;Ion Channel;Irritable Bowel Syndrome;Kinetics;Laboratories;Lectin;lentivirally transduced;low and middle-income countries;Maintenance;Malabsorption Syndromes;Malnutrition;Mediating;Membrane Glycoproteins;Military Personnel;Molecular;monolayer;Morbidity - disease rate;mortality;Mus;Nature;pathogen;Pathogenesis;Patients;Planets;Play;Predisposition;prevent;Prevention strategy;Production;receptor;Recombinants;Research;Resource-limited setting;response;Role;Sanitation;Small Intestines;Sodium Chloride;Soldier;Speed;stem cells;Symptoms;Testing;Therapeutic;therapy development;Tissues;Toxin;transcriptome;transcriptome sequencing;Transgenic Mice;treatment strategy;Tropical sprue;type 1 fimbriae;type 1 fimbriae receptor;United States;vaccine development;Vaccines;Veterans;Virulence;Water

PROJECT_TITLE: Molecular Pathogenesis of Enterotoxigenic Escherichia coli Infections


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Networking and Information Technology R&D (NITRD);Precision Medicine;Sepsis

ORG_CITY: CHAMPAIGN

ORG_NAME: PRENOSIS, INC.

PHR: Principal Investigator/Program Director (Last, first, middle): Reddy, Jr., Bobby Project Narrative: In this project, Prenosis will build upon this work to conduct targeted analyses of the individual treatment effects of corticosteroids on septic patient outcomes. Using samples that have already been collected and stored in the biobank, we will leverage our existing pipeline to measure the 40 core biomarkers for 8,100 samples on these 2,700 patients: the pre-treatment sample closest to the time at which the treatment patient received steroids, the sample closest to 24 hours after the treatment patient received steroids, and the patients’ final samples to understand how treatment impacted biomarker profile and how these changes are associated with clinical outcomes of interest. Analytics built upon these data and analyses could dramatically improve diagnostic, clinical decision support, and drug development products for sepsis and COVID.

PI_NAMEs: REDDY, BOBBY  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adrenal Cortex Hormones;Aftercare;Award;biobank;Biological Markers;Clinical;Clinical Data;clinical decision support;clinical trial recruitment;Clinical Trials;clinically relevant;Computerized Medical Record;COVID-19;Data;Data Set;demographics;Diagnostic;drug development;effective therapy;Ensure;Euclidean Space;follow-up;Frustration;Grant;Health;Heterogeneity;Hospitals;Hour;Housing;Immune response;improved;Individual;Infection;interest;Intervention;Length of Stay;Location;Machine Learning;Maps;Measurement;Measures;Methods;Modeling;mortality;National Institute of General Medical Sciences;novel;Outcome;patient biomarkers;patient subsets;Patient-Focused Outcomes;Patients;Plasma;Principal Investigator;product development;programs;protein biomarkers;response;Sampling;Sepsis;septic patients;Series;Serum;Site;Steroids;Subgroup;Surrogate Endpoint;Syndrome;Techniques;Testing;Time;treatment effect;two-dimensional;Work

PROJECT_TITLE: Combined Biomarker and EMR Data for Heterogeneous Treatment Effects and Surrogate Endpoints in Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(11)B]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Young women in South Africa are at high lifetime risk of contracting HIV, and will benefit enormously from a safe, effective HIV vaccine once it is available. However, as we know from the roll-out of the COVID-19 vaccine and from more than a decade of HIV vaccine trial recruitment, misinformation can reduce interest in or willingness to take the vaccine. In this study, we test messages that work like a “information vaccine” to build resistance to misinformation that young women may hear about the HIV vaccine; results from this study will help inform how to communicate about the HIV vaccine in South Africa to ensure that vulnerable groups like adolescent girls and young women can benefit from the vaccine's protection against HIV.

PI_NAMEs: BUTTENHEIM, ALISON MEREDITH (contact);MAUGHAN-BROWN, BRENDAN GEOFFREY;THIRUMURTHY, HARSHA

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: 2 arm randomized control trial;Africa South of the Sahara;aged;Attention;Behavioral;behavioral economics;Behavioral trial;Characteristics;Cognitive;Communication;Complement;Contracts;COVID-19 pandemic;COVID-19 vaccine;Decision Making;design;efficacy evaluation;Epidemic;Exposure to;Female Adolescents;fighting;follow-up;Future;Goals;Hearing;heuristics;high risk;HIV;HIV Infections;HIV risk;HIV vaccine;Immunity;Incidence;Individual;infodemic;innovation;insight;Institution;interest;lifetime risk;Lived experience;Medical Research;Misinformation;novel;Pattern;Population;pre-exposure prophylaxis;programs;Province;psychologic;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Resistance;response;Safety;Science;South Africa;Subgroup;Surveys;Testing;theories;Time;Trust;Vaccination;vaccine acceptance;vaccine candidate;vaccine hesitancy;vaccine trial;vaccine-induced immunity;Vaccines;Visit;Vulnerable Populations;willingness;Work;young woman

PROJECT_TITLE: Inoculating and boosting against HIV vaccine misinformation among adolescent girls and young women in South Africa


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE CRISPR-Cas systems are diverse bacterial immune systems that provide anti-viral defense, and have been exploited as programmable nucleases for a multitude of biotechnology and disease treatment applications. We will use Listeria seeligeri as a model microbe to investigate the activities of the RNA-targeting CRISPR-Cas13 system in its natural host. The research proposed here will both yield a deeper mechanistic understanding of how these unique CRISPR systems affect their hosts during anti-viral immunity, and also guide the development and application of Cas13-based biotechnologies that benefit human health.

PI_NAMEs: MEESKE, ALEXANDER JACOB (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: abortion;Adaptive Immune System;Affect;Antibiotics;antiviral immunity;Bacteria;Bacterial RNA;bactericide;Bacteriophages;Biotechnology;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Deoxyribonucleases;Development;Disease;DNA;Escherichia coli;Goals;Growth;Guide RNA;Health;Human;Immune system;Immunity;Infection;insight;Knowledge;Laboratories;Life Cycle Stages;Listeria;Microbe;Modeling;Molecular Biology;nuclease;Nucleic Acids;overexpression;pathogenic bacteria;persistent bacteria;Physiology;Research;Ribonucleases;RNA;Study models;System;targeted treatment;Therapeutic Intervention;tool;Transcript;Viral;viral RNA

PROJECT_TITLE: CRISPR-Cas13 immunity in Listeria seeligeri

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative: Surgical decision-making is challenging for persons living with dementia (PLWD) due to limited longitudinal data on outcomes, a patient's limited ability to fully participate in the discussion, and an absence of evidence- based guidelines. We propose a mixed methods study to understand the epidemiology of surgery for PLWD, as well as patient, caregiver, and provider practices and challenges of surgical decision-making in clinical settings. We focus on surgery because it is common among elderly PLWDs, it often represents a critical inflection point in quality of life, and therefore is a fraught process for all involved.

PI_NAMEs: WEISSMAN, JOEL S. (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Advance Care Planning;advanced directive;Affect;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Blood Vessels;Caregivers;Caring;Case Mixes;Case Study;Clinical;Communication;Communities;comparative;Consensus;cost;Data;Databases;Decision Making;Dementia;design;Development;Elderly;Epidemiology;evidence base;evidence based guidelines;expectation;Face;Family;Family Caregiver;Friends;Future;Goals;Guidelines;Health;health care service utilization;Health system;Home;improved;inpatient surgery;Life;Link;Medical;Medicare;Medicare claim;Methods;novel;nursing home length of stay;Nursing Homes;Operative Surgical Procedures;Outcome;pain perception;Palliative Care;Patient Care;Patient Preferences;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Policies;Postoperative Period;practice setting;Procedures;Process;Provider;Quality of life;Recommendation;Recovery;reduce symptoms;Research;Research Priority;Risk;Risk Factors;Sampling;shared decision making;Surgeon;surgery outcome;Surgical Management;surgical risk;Symptoms;System;Testing;tool;Training;Uncertainty;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Understanding and Improving Surgical Decision-Making for Persons Living with Dementia, their Family Caregivers, and their Providers: A Mixed Methods Study

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF THE INCARNATE WORD

ORG_STATE: TX

PHR: T35 Program Plan  Enhancement of Optometric Education with Basic, Applied and Clinical Research Narrative Our proposed T35 Training Grant will afford Faculty mentored research training to four Optometric Interns per year for 8-weeks during summer between the 1st and 2nd year of their professional education. It will perpetuate and enhance our current highly successful Summer Fellowship Training Program.

PI_NAMEs: RABIN, JEFFREY C (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Applied Research;Basic Science;career;Clinical Research;Collaborations;college;Diagnosis;Discipline of Nursing;Early Diagnosis;Education;Engineering;experience;Eye diseases;Faculty;Fellowship;Fostering;Funding;Goals;Grant;improved;Industry;Institution;Internships;Mathematics;medical schools;meetings;Optometry;Paper;Peer Review;Pharmacy facility;Physical therapy;Population;Positioning Attribute;Postdoctoral Fellow;posters;programs;Qualifying;Research;research faculty;Schools;Science;success;Training;Training Programs;Translational Research;Universities;Vision


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Skeletal disorders, such as osteoporosis, inflammatory osteolysis, osteoarthritis, skeletal deformities, and bone metastasis afflict a large proportion of the elderly population. This training program educates and forms the next generation of scientists and physician-scientists committed to make discoveries on skeletal disorders, so that a better understanding of the causes of these diseases can be achieved, and the search for new treatment modalities can progress.

PI_NAMEs: CIVITELLI, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: skeletal disorder;Training Programs

PROJECT_TITLE: Skeletal Disorders Training Program


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative The goal of this project is to develop novel computational methods to predict the impact of multiple changes in DNA sequence on overall cellular state and help IGVF consortium data collection and analysis strategies. Ultimately, we will generate an atlas of not only individual genetic variants to phenotype associations but, more importantly, entire genotype to phenotype predictions. These efforts represent crucial steps toward enabling genomic medicine by comprehensively linking genotype with cellular phenotype.

PI_NAMEs: BOYLE, ALAN P (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Adult;Affect;Algorithms;Atlases;Automobile Driving;Binding;Biological;cell type;Cells;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Computing Methodologies;Coupled;Data;Data Analyses;Data Collection;data dissemination;data modalities;Data Set;Disease;disease phenotype;DNA Sequence;Elements;epigenome;epigenomics;Exercise;Experimental Designs;experimental study;Gene Expression;generative models;Genes;genetic variant;Genetic Variation;Genomic medicine;genomic variation;Genotype;Genotype-Tissue Expression Project;Germ Lines;Goals;graph neural network;Human body;human tissue;Individual;Knock-out;Link;Maps;Measurement;meetings;Methods;Modality;model building;Modeling;Molecular;Normal Cell;novel;Organism;Phenotype;Population;predictive modeling;Protocols documentation;Publishing;Regulatory Element;Research Personnel;Resolution;Resources;Side;single cell technology;single-cell RNA sequencing;Specificity;statistical learning;Structure;Surveys;tool;transcription factor;transcriptome;transcriptomics;Untranslated RNA;Validation;Variant;working group

PROJECT_TITLE: Predicting the Impact of Genomic Variation on Cellular States