ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative This project will provide a detailed characterization of human behavioral and neural responses to real-world object images degraded by visual noise or blur, with the goal of developing deep neural network (DNN) recognition models that can better approximate the robust neural computations performed by the human visual system. The foundational knowledge gained from this research will inform our understanding of central visual disorders, including both acquired and neurodevelopmental disorders. The development of more robust, human-like DNN models is also of considerable relevance to AI applications in computer vision, including the analysis and evaluation of medical images.

PI_NAMEs: TONG, FRANK  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Animals;Architecture;Automobile Driving;base;Behavioral;Brain;Brain Diseases;Brain Injuries;Brain Neoplasms;Classification;cognitive neuroscience;computational neuroscience;Computer Vision Systems;Craniocerebral Trauma;Data;deep neural network;design;Development;Disease;Evaluation;experience;experimental study;Eye;Face;flexibility;Functional Magnetic Resonance Imaging;Future;Goals;Human;human model;Image;image processing;improved;inferotemporal cortex;Inherited;Knowledge;Learning;Macaca;Mediating;Medical Imaging;Methods;Modeling;Nature;Nervous System Disorder;neural;neural network architecture;Neural Network Simulation;Neurodevelopmental Disorder;Neurons;Noise;object recognition;Perceptual learning;Performance;Persons;Positioning Attribute;predictive modeling;Protocols documentation;Psychophysics;Recurrence;Regimen;Research;Resolution;response;Role;Sampling;Shapes;Stimulus;Stroke;Training;Vision;Vision Disorders;Visual;Visual Cortex;visual neuroscience;Visual Pathways;visual stimulus;Visual System;Work

PROJECT_TITLE: Neural and computational mechanisms underlying robust object recognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: CARVILL, GEMMA LOUISE (contact)

PROJECT_TERMS: 3-Dimensional;Algorithms;American;annotation  system;Back;Benign;Biochemical;Bioinformatics;California;care providers;Cells;Classification;clinical care;ClinVar;cohort;Communities;Complex;Computer Models;Computer software;Data;data management;Data Set;data sharing;Decision Making;Epilepsy;Family;gene discovery;Genes;Genetic;genetic testing;genetic variant;Genomic approach;genomic data;Goals;Health Personnel;Human;in vitro Model;in vivo;Induced Neurons;Industry;industry partner;Institution;Internet;Knowledge;machine learning model;Maps;Medical Genetics;medical schools;Michigan;Mission;Modeling;neurogenetics;neuron development;Neurons;novel;online resource;Online Systems;Pathogenicity;Patients;Population;Population Database;prediction algorithm;predictive modeling;predictive tools;Prevalence;Process;Property;protein structure;Proteins;Proteomics;Reporting;Research Personnel;Rodent;Roentgen Rays;San Francisco;skills;statistical and machine learning;Structural Models;Structure;Test Result;Testing;tool;Trans-Omics for Precision Medicine;Universities;Variant;variant of unknown significance;Washington;Work;working group;Zebrafish

PROJECT_TITLE: Gene Variant Curation Core (GVCC)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PI_NAMEs: ARFANAKIS, KONSTANTINOS  (contact)

PROJECT_TERMS: age related;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Area;Autopsy;Biological Markers;Blood Vessels;Brain;brain magnetic resonance imaging;Characteristics;Chemicals;Classification;Clinical;Clinical assessments;Cognitive;Cognitive aging;Collaborations;Collection;Data;data acquisition;Data Collection;data hub;data management;data sharing;Databases;Dementia;Development;education research;Enrollment;ethnic disparity;Exercise;Funding;Goals;Health;health disparity;Impaired cognition;in vivo;Interdisciplinary Study;Leadership;Link;Magnetic Resonance Imaging;Mentors;mild cognitive impairment;minority health;Motor;multimodality;Nerve Degeneration;neuroimaging;neuropathology;normal aging;novel;novel marker;older adult;Online Systems;Outcome;Output;Participant;peripheral blood;Persons;Pilot Projects;Positron-Emission Tomography;Process;Protocols documentation;racial disparity;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;retinal imaging;Risk Factors;Role;Standardization;tool;Validation

PROJECT_TITLE: Core F: Biomarker/Neuroimaging Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PI_NAMEs: DANG, LOUIS TUONG CHINH (contact)

PROJECT_TERMS: 3-Dimensional;Astrocytes;Blood;Cell Differentiation process;Cell Line;cell type;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Core Facility;CRISPR/Cas technology;Dedications;Derivation procedure;design;Development;developmental disease;differentiation protocol;directed differentiation;disease model;Doxycycline;Embryo;Engineering;Epilepsy;experience;expression vector;Fibroblasts;Floor;Funding;gene interaction;Gene Mutation;Generations;Genes;genetic selection;genetic variant;genome editing;Glutamates;Heterozygote;Human;human embryonic stem cell;human embryonic stem cell line;human induced pluripotent stem cells;human pluripotent stem cell;Human Resources;human stem cells;in vitro testing;Individual;induced pluripotent stem cell;insertion/deletion mutation;Knock-in;Knock-out;Laboratories;Lead;Mediating;medical schools;Methods;Michigan;Modeling;Motor Neurons;Mutagenesis;mutant;Mutation;mutation correction;nerve stem cell;Nervous System Disorder;neural;Neurologic;Neurology;Neuronal Differentiation;Neurons;novel;novel strategies;operation;Organoids;Parents;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Play;pluripotency;Procedures;Protocols documentation;Quality Control;regenerative therapy;repository;Research;Research Personnel;Resources;Role;Sampling;Scientist;Sequence Deletion;Services;skills;Southern Blotting;Specific qualifier value;Standardization;stem cell model;stem cells;Techniques;Testing;Tissues;tool;Training;transgene expression;Transgenes;Transgenic Organisms;Universities;Validation;Variant;vector;Work

PROJECT_TITLE: Human Epilepsy Tools Core (HETC)


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PUBLIC HEALTH RELEVANCE/NARRATIVE Aβ peptides and amyloid plaques play important roles in the early stages of Alzheimer's disease (AD), and the importance of amyloid pathology in AD is supported by several recent FDA approvals. But there is a lot about these pathological hallmarks that we do not understand. This project aims to address the urgent clinical need to better understand Aβ dynamics during progression of amyloid plaque pathology in AD.

PI_NAMEs: HANRIEDER, JORG ;SAVAS, JEFFREY NICHOLAS (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Address;Aducanumab;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;Antibodies;Autopsy;Axon;Brain;Brain Diseases;brain tissue;Characteristics;Chronology;Classification;Clinical;cognitive performance;Communication;Communities;Complex;Confocal Microscopy;conformational conversion;Data Set;Defect;Dementia;Dendrites;Dendritic Spines;density;Deposition;Disease Progression;Dissection;Electrophysiology (science);Endocytosis;Event;Excision;Extracellular Space;Fluorescent Dyes;Functional disorder;genetic risk factor;Glutamates;Goals;Hippocampus;hyperphosphorylated tau;Image;image guided;Impaired cognition;Impairment;Individual;Kinetics;Knock-in Mouse;Knowledge;Label;Lasers;Link;Lipids;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolism;Methods;Molecular;molecular phenotype;Molecular Profiling;mouse model;multiple omics;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuronal circuitry;Neurons;Neurosciences Research;neurotoxicity;novel strategies;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peptides;Persons;Play;Positron-Emission Tomography;Presynaptic Terminals;prevent;Probability;Process;protein aggregation;Protein Analysis;protein degradation;Protein Dynamics;Proteins;Proteomics;proteostasis;public health relevance;Radial;Recycling;Research;Resolution;response;Risk Factors;Rodent;Role;Senile Plaques;Stable Isotope Labeling;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;tau aggregation;tau Proteins;Testing;Time;timeline;tissue fixing;TREM2 gene;United States;vesicular release

PROJECT_TITLE: Understanding Amyloid Pathology - Multiomic Activity Imaging of Plaque Formation Dynamics (AmyMAP)


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Here, we propose a Center without Walls, entitled Epilepsy Multiplatform Variant Prediction (EpiMVP), spanning five institutions and incorporating expertise from geneticists, clinicians, computational biologists, neuroscientists, stem cell biologists, pharmacologists and electrophysiologists who have a proven track record of collaborative publications and grants, as well as stature as leaders of national and international epilepsy organizations. EpiMVP will develop a modular, highly integrated platform approach to accelerate determination of the functional, pharmacological, neuronal network and whole animal consequences of genetic variants among a range of clinical epilepsy types. Our ultimate goal is to devise an effective platform for testing the pathogenicity of variants of uncertain significance in non-ion channel, non-receptor genes implicated in epilepsy and for identifying potential targets for future intervention.

PI_NAMEs: ISOM, LORI L. (contact);PARENT, JACK M

PROJECT_TERMS: Acceleration;Animals;Benign;Biodiversity;Biological;Biological Process;Brain;candidate selection;Cells;Classification;Clinical;clinical care;ClinVar;Computer Models;Data;data modeling;Development;Disease;disease mechanisms study;DNA sequencing;early onset;Epilepsy;exome sequencing;Experimental Models;Family;Future;gene discovery;gene panel;Genes;genetic counselor;genetic testing;genetic variant;Goals;Grant;Guidelines;Human;human disease;human pluripotent stem cell;In Vitro;in vivo Model;induced pluripotent stem cell;innovation;Institution;International;Intervention;Intractable Epilepsy;Ion Channel;Ligands;machine learning model;Needs Assessment;Neurons;new therapeutic target;next generation;novel strategies;novel therapeutics;Organoids;Outcome;Pathogenicity;Pathway interactions;Patient Care;Patients;personalized medicine;pharmacologic;pre-clinical;Pre-Clinical Model;predictive modeling;predictive tools;Proteins;Publications;receptor;stem cells;System;Testing;Variant;variant of unknown significance;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Brain Disorders;Cardiovascular;Down Syndrome;Heart Disease;Heart Disease - Coronary Heart Disease;Intellectual and Developmental Disabilities (IDD);Pediatric;Prevention;Psoriasis

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Project Narrative This project is a novel study of psoriasis in individuals with Down syndrome (DS). Psoriasis is associated with increased cardiometabolic risk factors and cardiovascular disease in the general population; however, this association has never been explored in people with DS who are considered protected against cardiovascular disease. This study will use a population-level database to enhance our understanding of psoriasis in people with DS and explore if psoriasis could present an exception to their presumed cardiovascular disease resilience.

PI_NAMEs: RORK, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: EGERSON, D'ANDREA R

PROJECT_TERMS: Adult;Affect;Age;American;American Heart Association;Atherosclerosis;Awareness;Body System;burden of illness;Cardiology;cardiometabolic risk;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;Case Series;Case Study;Cause of Death;Cerebrovascular Disorders;Characteristics;Child;Childhood;Chromosome 21;Chronic;Clinical;clinical database;Code;college;Communities;comorbidity;Comprehensive Health Care;Coronary Arteriosclerosis;Coronary artery;Cross-Sectional Studies;cytokine;Data;data integration;data platform;Databases;Demographic Analyses;demographics;Dermatologic;design;Diagnosis;Diagnostic;Disease;Down's Syndrome;Drug Prescriptions;Dyslipidemias;Evaluation;Event;evidence base;Functional disorder;Future;General Population;Genes;Guidelines;Health;Hospitalization;Hyperactivity;Hypertension;Immune;Immunologics;Immunology;improved;Individual;Inflammatory;innovation;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;interest;Interferon Type II;Interferons;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Investigation;Laboratories;Life Expectancy;Link;Literature;Measurement;Mediating;Medical;Metabolic syndrome;Methodology;Monitor;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Office Visits;Pathway interactions;Patients;Peripheral;Persons;Physiological;Population;Population Research;Psoriasis;Recommendation;Records;Research;resilience;Risk;Risk Factors;Severities;Severity of illness;Skin;skin disorder;Sleep Apnea Syndromes;Stroke;Supervision;Systemic disease;systemic inflammatory response;Thinking;tool;Trisomy;United States;Visit

PROJECT_TITLE: Down syndrome and Psoriasis: An Investigation of Cardiometabolic Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE: We propose to conduct research that will determine the impact of relevant behaviors on HIV prevention among Young Black Sexual Minority Men (YBSMM), such as heavy cannabis use. We propose to explore mechanisms, specifically neurocognitive impacts of heavy cannabis use, linking heavy cannabis use to HIV prevention outcomes (and particularly PrEP use), and whether motivations for cannabis use, amidst a changing cannabis regulatory, social acceptance and legal landscape, modify its effects on HIV prevention. Identifying neurocognitive mechanisms through which cannabis use affects HIV prevention and the importance of motivations for cannabis use in understanding clinical outcomes will provide targets for future HIV prevention efforts.

PI_NAMEs: KEEDY, SARAH K;KNOX, JUSTIN ;SCHNEIDER, JOHN  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Adherence;Adolescence;Affect;AIDS prevention;Alcohols;Anxiety;Area;Awareness;Behavior;Biological;Bisexual;Black Populations;Black race;Brain;Cannabis;care outcomes;Caring;Chicago;Clinical;Cognitive;cohort;Communities;Continuity of Patient Care;COVID-19 pandemic effects;Data;Development;Disparate;Distress;emerging adult;Epidemic;executive function;Exhibits;Face;Funding;Future;Gays;Goals;Health;high risk;HIV;HIV Seronegativity;Home;Human immunodeficiency virus test;improved;Incidence;Individual;Legal;Link;marijuana use;marijuana user;Measures;Medical;member;Motivation;National Institute of Drug Abuse;Nature;neural;Neurocognition;Neurocognitive;neuroimaging;Outcome;Pharmaceutical Preparations;Plasma;polysubstance use;pre-exposure prophylaxis;pressure;Prevention;Prevention program;primary outcome;Process;racial disparity;Recreation;recruit;Research;resilience;response;reward processing;Rewards;Risk;Self Care;sex;Sex Behavior;sexual minority men;sexual risk behavior;Side;social;Stress;substance use;suburb;Support System;Surveys;System;Testing;Therapeutic;tool;transmission process;United States National Institutes of Health

PROJECT_TITLE: Heavy cannabis use, neurocognition and PrEP care engagement among young Black sexual minority men


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: BENNETT, DAVID ALAN (contact)

PROJECT_TERMS: Address;Aging;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Asia;Australia;Autopsy;Biological;Biological Markers;Black Populations;Blood;Brain;brain magnetic resonance imaging;Brain Pathology;Cell model;Chicago;Clinical;Clinical Data;Cognitive aging;Collaborations;Communities;Country;County;Data;Data Collection;data management;data sharing;Dementia;design;Diagnosis;Disease;disease model;Enrollment;Ensure;Etiology;Europe;Exclusion;follow-up;Funding;Goals;Health;health disparity;Heterogeneity;Human;human data;Impaired cognition;improved;in vivo;Infrastructure;innovation;Latino;Latino Population;Link;Magnetic Resonance Imaging;Manuscripts;Memory;men;Methods;Middle East;Minority;Molecular Profiling;motor impairment;multidisciplinary;Nature;neuroimaging;neuropathology;Normalcy;North America;Online Systems;open data;operation;outreach;Paper;Pathogenesis;Peer Review;Persons;Population Study;Positioning Attribute;Precision Health;precision medicine;predictive modeling;Process;public-private partnership;Recommendation;recruit;Religion;religious order study;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Risk Factors;Sister;South America;Specimen;Strategic Planning;Structure;Systems Biology;tool;virtual;Woman;Work

PROJECT_TITLE: Core H: Religious Orders Study Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative The goal of the proposed project is to elucidate and characterize neurons and circuits in the brain that directly respond to stress, drive anxiety, and induce avoidance behavior in the healthy and nicotine-dependent brain. It is anticipated that this work will yield new insights into brain areas that respond to stress, shape stress-induced behaviors, and contribute to nicotine addiction.

PI_NAMEs: TAPPER, ANDREW R (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acute;acute stress;addiction;Animal Model;Anxiety;anxiety-like behavior;Area;avoidance behavior;base;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain;Brain region;Buffers;Calcium Signaling;Chronic;conditioned place preference;CRF receptor type 1;Data;Development;dopaminergic neuron;Dorsal;Dose;Drug abuse;Drug Addiction;drug development;drug of abuse;Drug user;experimental study;Extinction;Fiber;Foundations;Functional disorder;Goals;Hypothalamic structure;in vivo;insight;Instinct;Intake;interpeduncular nucleus;Lateral;laterodorsal tegmentum;Link;Measures;Medial;Mediating;Mediator;Midbrain structure;Monitor;Mus;negative affect;Neurons;Neuropeptides;neurotransmission;Nicotine;Nicotine Dependence;Nicotine Withdrawal;Nicotinic Receptors;novel;novel therapeutic intervention;Opsin;optogenetics;Pathway interactions;Pharmaceutical Preparations;Photometry;preference;Proxy;Publishing;Regulation;Relapse;relapse risk;response;restraint;reward circuitry;Risk Factors;Rodent Model;selective expression;sensor;Shapes;single cell sequencing;Smoking;Somatostatin;Stimulus;Stress;Stress Tests;Stressful Event;stressor;Tegmentum Mesencephali;Testing;vaping nicotine;Ventral Tegmental Area;Withdrawal;Work

PROJECT_TITLE: Interpeduncular circuitry in stress-responsive behaviors and nicotine dependence

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MARQUEZ, DAVID X (contact)

PROJECT_TERMS: Acceleration;Address;Agreement;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Autopsy;Awareness;Biological;Biological Markers;Blood;Brain;brain tissue;Cessation of life;Clinical;Clinical Data;Clinical Research;Collaborations;Communities;Data;Data Collection;data management;data sharing;Dementia;design;Diagnosis;disease model;Disparity;diverse data;Education;Enrollment;Ensure;Epidemiology;epigenomics;Equity;ethnic diversity;Ethnic Origin;Etiology;experience;Funding;Genomics;Goals;Health Disparities Research;health disparity;Heterogeneity;human data;Impaired cognition;improved;in vivo;knowledge base;Latina;Latino;Latino Population;Link;men;Mentorship;metabolomics;Methods;mild cognitive impairment;Molecular Profiling;motor impairment;multidisciplinary;Nature;neuroimaging;neuropathology;nonalzheimer dementia;normal aging;Normalcy;older adult;Online Systems;open data;outreach;Participant;Pathogenesis;Pathway interactions;personalized approach;Population;predictive modeling;Process;Productivity;programs;Proteomics;public-private partnership;Race;racial diversity;Recommendation;Recording of previous events;recruit;Reporting;Research;research clinical testing;Research Project Grants;research study;Resources;response;Risk Factors;Science;Specimen;Strategic Planning;Structure;success;Time;tool;Training Activity;underserved community;virtual;Woman

PROJECT_TITLE: Core I: Latino Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Shared decision making is a key part of high-quality care for adolescents with chronic conditions and their families. Yet, because no measure of adolescent shared decision making exists, it is impossible to evaluate whether efforts to improve shared decision making and improve adolescents’ outcomes are successful. Thus, this project will develop and validate the first adolescent and parent reported measure of adolescent shared decision making.

PI_NAMEs: CARLE, ADAM CHRISTOPHER (contact);LIPSTEIN, ELLEN A

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Developing and Validating an Adolescent and Parent Reported Measure of Pediatric Shared Decision Making

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE This project will assess whether an intervention that shows a patient’s medication out-of-pocket cost to clinicians via the Electronic Health Record when the medication is being ordered improves access to medications and quality of care for Black, Hispanic or Latino, and rural patients with chronic conditions. High out-of-pocket costs and medication unaffordability are principal drivers of lower rates of use of effective medications and lower rates of guideline concordant care among these patient populations. This study will inform how, if at all, the intervention leads to increased receipt of treatment services consistent with national evidence-based recommendations and reductions in preventable outcomes for these patients, and whether the impact was different during the COVID-19 pandemic.

PI_NAMEs: SINAIKO, ANNA D (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: acute care;Address;Affect;Ambulatory Care;Area;Asthma;Atrial Fibrillation;Attitude;Behavior;Belief;Black Populations;Black race;care episode;Caring;Characteristics;Chronic;Chronic Disease;Clinical;clinical encounter;Colorado;cost;cost estimate;COVID-19 pandemic;Data;data registry;Data Set;data tools;demographics;design;Diabetes Mellitus;Discrimination;Disease;Disparity population;disparity reduction;Electronic Health Record;ethnic minority;Ethnic Origin;evidence base;evidence based guidelines;experience;Focus Groups;Frequencies;Goals;Guidelines;Health;health disparity;health literacy;Health Status;Health system;Healthcare Systems;Hispanic;Hispanic Populations;Household;implementation strategy;implementation tool;Improve Access;improved;Income;Intervention;Interview;Language;Latino;Latino Population;Learning;Link;longitudinal dataset;Marketing;Measures;Medical;Medicare;Mental Depression;Morbidity - disease rate;mortality;novel;Outcome;patient population;Patient Preferences;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacy facility;Policies;poor health outcome;Population;practice factors;preference;Provider;Quality of Care;Race;racial minority;Registries;Research;Residencies;Resources;Rural;rural area;rural patients;Rural Population;rural residence;Sampling;Site;Structural Racism;System;Telemedicine;Time;tool;Travel;treatment choice;treatment services;Trust;Underserved Population;Uninsured Medical Expense;Universities;Variant

PROJECT_TITLE: Evaluating an Intervention to Improve Medication Access and Quality of Care for Underserved Populations With Chronic Conditions

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Genetics;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The goal of this project is to identify the factors related to high resistance to substance use. Factors increasing resistance may have the highest impact in maintaining or leading to health, as opposed to disease. Identifying these factors requires novel methods developed for this study, and developmental data – from childhood to adulthood – already available and newly obtained in this project in a sample of twins.

PI_NAMEs: MAES, HERMINE H;PROM-WORMLEY, ELIZABETH CHIN (contact);VANYUKOV, MICHAEL M

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Accounting;addiction;addiction liability;Address;Adolescence;Adolescent;Adult;Age;age related;aggregation factor;Behavioral;Calibration;Childhood;Classification;Cohort Studies;concept mapping;Data;Data Collection;data mining;Detection;Development;Diagnosis;Disease;Drug user;enhancing factor;Environment;Environmental Risk Factor;Face;Failure;Family Study;Genetic;genetic approach;genetic manipulation;Genotype;Goals;Health;Heritability;high risk;Illicit Drugs;indexing;Individual;Intervention;Life Cycle Stages;Measurement;Measures;Methods;Minnesota;model development;Modeling;novel;Outcome;Participant;Phenotype;Population;population based;Prevalence;Prevention;Prevention strategy;Probability;protective factors;psychologic;recruit;reduced substance use;Research;Resistance;Resistance development;resistance factors;response;Risk;Risk Factors;Sampling;Severities;Source;Substance Addiction;substance use;substance use prevention;success;Symptoms;Testing;theories;trait;Translating;treatment strategy;Twin Multiple Birth;Twin Studies;United States;Update;Variant;Virginia

PROJECT_TITLE: Using a Genetic Approach to Understand Factors Influencing Resistance to Substance Use

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PI_NAMEs: BOYLE, PATRICIA A (contact)

PROJECT_TITLE: Core G: Research Education Component (RL5)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Cost Effectiveness Research;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: This study will develop a comprehensive risk prediction model based on genetic and environmental/lifestyle risk factors different genetic ancestral population groups. To translate this multi-ancestral risk prediction model into clinical practice, we will use microsimulation modeling to personalize screening recommendations based on genetic and environmental risk factor information and we will develop a web-based risk communication tool which we will evaluate in participants of different genetic ancestry. Results from our study will ensure that targeted personalized interventions will confer similar benefits for all Americans regardless of their genetic ancestry.

PI_NAMEs: PETERS, ULRIKE  (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;African American population;Age;age effect;Age of Onset;American;Asian population;Cancer Burden;Cancer Etiology;cancer health disparity;Cessation of life;Clinical;clinical practice;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;colorectal cancer treatment;commercialization;Communication Tools;Communities;community advisory board;Complex;cost;Cost Effectiveness Analysis;cost-effectiveness evaluation;Data;Death Rate;Decision Modeling;design;Development;Diagnosis;Disease;early onset colorectal cancer;Ensure;Environmental Risk Factor;Equity;Ethics;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;European;European ancestry;Evaluation;Genetic;genetic approach;Genetic Research;Genetic Risk;genetic risk factor;genome-wide;Genomics;Genotype;implementation science;improved;Incidence;Individual;individual patient;individualized prevention;Latino Population;Lead;Life Style;Mind;Minority;Minority Groups;Minority Health Research;Modality;Modeling;models and simulation;Not Hispanic or Latino;novel strategies;Online Systems;Participant;personalized intervention;personalized screening;polygenic risk score;Population;Population Genetics;Population Heterogeneity;precision medicine;preference;Prevention;Race;racial diversity;racial minority;racial minority population;racial population;recruit;Research;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;Science;screening;screening guidelines;sex;Side;tool;Translating

PROJECT_TITLE: Advancing equity in colorectal cancer genetic risk prediction through expansion of racial/ethnic minority representation

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative In this proposal, our interdisciplinary team proposes to develop and validate innovative methods to advance personalized risk prediction models in the presence of missing and biased EHR data We propose to develop: 1) effective sample-weighting method to correct biases in risk factor selection and estimation for population inferences (Aim 1), 2) flexible deep learning method for EHR personalized risk prediction with fairness criteria (Aim 2); and 3) innovative calibration method to improve reproducibility of EHR-based risk models between institutions (Aim 3). We will assess and validate the developed methods on the New York City Clinical Data Research Network (NYC-CDRN).

PI_NAMEs: SMYTH, PADHRAIC ;ZHONG, HUA JUDY (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Age;Algorithms;Benchmarking;Biological Markers;Calibration;Cardiovascular Diseases;Characteristics;Chronic Disease;Clinical;Clinical Data;Clinical Medicine;Clinical Research;cohort;computer scientist;Computing Methodologies;Data;data modeling;Data Set;data standards;deep learning;demographics;Development;Diagnosis;Disease;Disease Outcome;Disparate;Drug Prescriptions;electronic health data;Electronic Health Record;experience;flexibility;Frequencies;Gender;Health;health care service utilization;Health Surveys;Healthcare;Hospitals;improved;Individual;innovation;Institution;interest;Interview;Link;maltreatment;Medical;Methodology;Methods;Modeling;Neural Network Simulation;New York;New York City;Non-Insulin-Dependent Diabetes Mellitus;Outcome;patient population;patient subsets;Patients;personalized risk prediction;Physical assessment;Population;population based;population health;predictive modeling;Probability;Procedures;Race;Records;recurrent neural network;Reproducibility;Research;Research Personnel;Retirement;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;Sampling;Site;Software Tools;Statistical Methods;Surveys;System;Universities;Validation;Variant;Visit;web app

PROJECT_TITLE: Personalized Risk Predictions with Deep Learning Methods in the Presence of Missing and Biased Electronic Health Record Data

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Type 1 diabetes occurs due to autoimmune destruction of insulin-secreting beta cells in the pancreas. Identifying target molecules (i.e. antigens) for T-immune cells is important to develop immunotherapy to halt autoimmune attack against beta cells and ultimately prevent and sure type 1 diabetes. In this project, we will characterize antigen specificity and phenotypes of T-immune cells that are involved in the pathogenesis of type 1 diabetes.

PI_NAMEs: NAKAYAMA, MAKI  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Affinity;Alleles;Amino Acid Motifs;Antibodies;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoantibodies;Autoimmune Diseases;autoimmune pathogenesis;Automobile Driving;Bar Codes;Beta Cell;Biological;Biological Assay;Blood;CD4 Positive T Lymphocytes;cell motility;Cell Separation;Cells;cellular transduction;Clinical Trials Design;combinatorial;Computer Analysis;Development;diabetes pathogenesis;Diabetes prevention;diabetes risk;Disease;disease heterogeneity;Disease Progression;DNA;Epitopes;genetic association;genomic locus;Glutamate Decarboxylase;Goals;Grant;gut microbiome;Health;Heterogeneity;HLA-DR3 Antigen;HLA-DR4 Antigen;Human;Hybridomas;Hybrids;Immune;Immunotherapy;improved;Individual;Inflammatory;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Islet Cell;islet cell antibody;Islets of Langerhans;Link;lymph nodes;Mass Spectrum Analysis;MHC Class II Genes;molecular phenotype;non-diabetic;Organ Donor;Pancreas;Pathogenesis;Pathogenicity;Patients;Peptide Library;Peptides;Phenotype;Positioning Attribute;preproinsulin;prevent;Process;Proinsulin;Protein Databases;Proteins;Reaction;response;Risk;Source;Specificity;Spleen;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Tissues;transcriptome;Virus;zinc-binding protein

PROJECT_TITLE: The Antigen Repertoire of CD4 T cells from Pancreatic Islets

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Diabetes;Kidney Disease

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  Diabetes is the most common metabolic disease in the world and the leading cause of end stage renal disease. The focus of this proposal is to examine the pathogenic role of dynamin-related protein 1 (Drp1), a key protein involved in mitochondrial fragmentation, in experimental models of diabetic kidney disease. The results of this study will provide important new insights into the role of mitochondrial morphology in the development of diabetic nephropathy, and may lead to novel therapeutic targets for the future treatment of diabetic kidney disease.

PI_NAMEs: DANESH, FARHAD R (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Alanine;Alleles;Animals;Biochemical;Biological;Biosensor;Cardiolipins;Cells;comparative;Complex;Cytochrome c Reductase;Data;db/db mouse;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;Disease;Dynamin;Electron Transport;End stage renal failure;Event;Exhibits;expectation;Experimental Models;Functional disorder;Future;gain of function;Generations;Genetic;Glucose;Green Fluorescent Proteins;Histologic;improved;In Vitro;in vivo;Inner mitochondrial membrane;Innovative Therapy;insight;interest;Investments;Iron-Sulfur Proteins;Kidney;Knock-in;Link;loss of function;Mediating;Mediator;Metabolic Diseases;mimetics;Mitochondria;Mitochondrial complex I deficiency;mitochondrial dysfunction;Mitochondrial Matrix;Molecular;Monitor;Morphology;mouse model;Mus;Mutant Strains Mice;Mutation;NADH dehydrogenase (ubiquinone);new therapeutic target;novel;Outer Mitochondrial Membrane;Oxidation-Reduction;Pathogenesis;Pathogenicity;Phosphorylation;Play;podocyte;Point Mutation;Post-Translational Protein Processing;Predisposition;prevent;Process;Production;Proteins;Publications;Publishing;Reactive Oxygen Species;recruit;Rho-associated kinase;Role;Serine;Signal Transduction;Site;Testing;therapeutic target;virtual

PROJECT_TITLE: Role of Rho Kinase in Diabetic Nephropathy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Hotspot mutations in the U2AF1 splicing factor gene (encoding U2AF1S34 and U2AF1Q157 mutants) are associated with different clinical features, outcomes, alternative splicing, and co-occurring gene mutations in patients with myelodysplastic syndromes (MDS). The proposed studies will test the hypotheses that different gene expression and alternative splicing programs are aberrantly induced by U2AF1S34F and U2AF1Q157R mutants, and that these distinct molecular perturbations contribute to the divergent hematopoietic phenotypes we observe in MDS patients, including cooperativity with other gene mutations (e.g., ASXL1). A better understanding of the mechanisms driving pathogenesis of U2AF1 mutant MDS could nominate vulnerabilities to therapeutically exploit in MDS patients harboring mutations in U2AF1 and other splicing factor genes.

PI_NAMEs: ALBERTI, MICHAEL O (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: 3' Splice Site;Academic Medical Centers;Acute Myelocytic Leukemia;Advisory Committees;Alternative Splicing;Animal Model;Automobile Driving;Basic Science;Biological Models;Biology;Blood;Bone Marrow Cells;Bone marrow failure;career;Clinical;clinical candidate;Clonal Hematopoietic Stem Cell;Codon Nucleotides;Core Facility;cytopenia;Data;Development;Disease;DNA Sequence Alteration;Dysmyelopoietic Syndromes;Elderly;Environment;experimental study;Functional disorder;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic;genetic signature;Goals;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Heterozygote;histone modification;Histones;In Vitro;in vivo;in vivo Model;Incidence;Individual;Ineffective Hematopoiesis;Knock-in Mouse;Laboratories;Mediating;Mentors;Modeling;Molecular;molecular pathology;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;novel;novel therapeutics;Outcome;Pathogenesis;Pathologist;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Physicians;Population;Pre-Clinical Model;programs;Protein Isoforms;Proteins;Recurrence;Regulation;Research;Research Personnel;Resources;Risk;RNA Splicing;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;Spliced Genes;Spliceosomes;SRSF2 gene;stem cell self renewal;Study models;success;supportive environment;synergism;Testing;Therapeutic;therapeutic evaluation;Training;transcriptome sequencing;Universities;Washington;Zinc Fingers

PROJECT_TITLE: Distinct roles of U2AF1 mutations in myelodysplastic syndrome pathogenesis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: An adverse prognosis subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is characterized by increased expression of a set of homeodomain transcription factors, including HoxA9 and A10. In preliminary studies, we found such acute myeloid leukemias were also characterized by activation of pathways involved in the innate immune response. In murine models of Hox-overexpressing AML, we found emergency granulopoiesis was enhanced and failed to resolve during the innate immune response; associated with accelerated leukemogenesis and shortened survival. We also found increased expression of proteins involved in the integrated stress response (ISR) during leukemogenesis in Hox-overexpressing murine models of AML. These results suggest the ISR may sustain EG and enhance accumulation of mutations leading to AML in the context of increased Hox expression. Molecular mechanisms involved in this may provide markers of adverse prognosis in a subset of myeloid malignancies and potential therapeutic targets to delay disease progression.

PI_NAMEs: EKLUND, ELIZABETH ANN (contact)

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;adverse outcome;Amino Acids;AML/MDS;Anti-Inflammatory Agents;biological adaptation to stress;Bone Marrow;Bone Marrow Transplantation;CD34 gene;Cell Cycle Progression;Cell Death;Cells;Chimeric Proteins;Chromosomes;Clinical;Clinical Research;comparison control;Defect;density;Development;Disease;Disease Progression;DNA Damage;Drug resistance;Dysmyelopoietic Syndromes;Emergency Situation;Event;exhaustion;exome sequencing;FLT3 gene;Fusion Oncogene Proteins;Genes;Genetic Transcription;Goals;granulocyte;Granulopoiesis;Hematopoietic stem cells;homeodomain;Human;human subject;immunoregulation;Impairment;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;knock-down;leukemia;leukemogenesis;Mediating;Messenger RNA;Metabolic;MLL gene;Modeling;Molecular;molecular marker;molecular subtypes;mouse model;mRNA Translation;Mus;Mutagenesis;Mutation;Myeloid Cells;Myeloid Leukemia;Myeloproliferative disease;Oncoproteins;overexpression;Pathway interactions;Patients;peripheral blood;Phosphorylation;Physiological;Polyribosomes;prevent;Process;Production;Prognosis;Proliferating;Protein Biosynthesis;protein expression;protein metabolism;Proteins;Proteomics;Receptor Protein-Tyrosine Kinases;Regulation;Repression;response;Ribosomes;RNA metabolism;Role;Site;stem;stem cells;Stress;therapeutic target;Time;transcription factor;transcriptome sequencing;Transfer RNA;Translations;translatome;transplant model;Transplantation;Twin Multiple Birth;Twin Studies;Tyrosine Phosphorylation;Ubiquitin;ubiquitin-protein ligase;Xenograft procedure

PROJECT_TITLE: Molecular mechanisms of drug resistance and disease progression in acute myeloid leukemia.


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Infectious diseases remain leading causes of death worldwide and infectious diseases physician-scientists are critical to the public health response to both old and new threats. The University of Pennsylvania and the Chil- dren’s Hospital of Philadelphia are world leaders in biomedical research. Our goal is to help train the next gen- eration of medical scientists to develop improved diagnostic, preventive, and therapeutic approaches for estab- lished and emerging infectious diseases.

PI_NAMEs: FRIEDMAN, HARVEY MICHAEL;ODOM JOHN, AUDREY RAGAN (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Combined Adult and Pediatric Infectious Disease Postdoctoral Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This study will examine to what extent hospital quality contributes to maternal racial/ethnic disparities in eight U.S. states, societal and individual level maternal factors associated with using versus bypassing high-quality hospitals, and whether Medicaid expansion has impacted hospital quality and maternal outcomes. Our project will result in understanding and ultimately reducing these disparities in maternal outcomes.

PI_NAMEs: BOGHOSSIAN, NANSI  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accounting;Address;Adult;adverse maternal outcomes;adverse outcome;Area;Biometry;Birth Certificates;black women;Bypass;California;care providers;Caring;Cities;Clinical;cost effective;Data;Data Set;design;Discipline of obstetrics;disparities in morbidity;Disparity;disparity reduction;Economics;effective intervention;Eligibility Determination;ethnic difference;ethnic disparity;ethnic health disparity;Ethnic Origin;experience;federal poverty level;Florida;Geography;health care delivery;health care disparity;Health Policy;Health Services Research;Healthcare Systems;Hispanic;Hispanic Women;Hospitals;improved;Incidence;Income;Individual;innovation;Insurance;Investigation;Link;Louisiana;Massachusetts;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Medicaid;Medical;Minority;Minority Women;Missouri;Morbidity - disease rate;Mothers;Natural experiment;Neonatology;New York City;Newborn Infant;Outcome;Patients;Pennsylvania;Perinatal Epidemiology;Play;Policies;Population;Pregnancy;Public Health;Quality of Care;Race;racial difference;racial disparity;racial health disparity;racial minority;Records;Reporting;Research;research study;Risk;Risk Adjustment;Role;Rural;rural area;Rural Population;safety net;severe maternal morbidity;sociodemographics;Socioeconomic Status;socioeconomics;South Carolina;Standardization;Structural Racism;Time;Transcend;Travel;Urban Hospitals;Urban Population;Variant;Very Low Birth Weight Infant;Vital Statistics;Washington;White Women;Woman;Work

PROJECT_TITLE: Hospital quality, Medicaid expansion, and racial/ethnic disparitiesin maternal mortality and morbidity


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Schizophrenia

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE We have identified a novel mechanism by which co-activation of two neurotransmitter receptors, called mGlu5 and mGlu3, can enhance synaptic plasticity and cognitive function. Employing a combination of highly selective pharmacological tools, genetic mouse models, as well as state of the art cellular and in vivo studies, we will test the hypothesis that this mGlu3/mGlu5 communication occurs in a specific population of neurons in the prefrontal cortex, a brain region that is involved in cognitive deficits in schizophrenia patients. We will then test the hypothesis that mGlu3 activation improves cognitive performance in rodents via a mechanism that is dependent on co-activation of mGlu5 and determine the ability of mGlu3 and mGlu5 to interact after animals have been treated with phencyclidine to induce cognitive deficits.

PI_NAMEs: CONN, P JEFFREY (contact);NISWENDER, COLLEEN M

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Ablation;Acute;Adolescent;Agonist;AMPA Receptors;Amygdaloid structure;Animal Model;Animals;Area;associated symptom;Brain;Brain Diseases;Brain region;Calcium;cell type;Chemosensitization;Clinical Research;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;cognitive performance;cognitive task;Communication;Data;Development;disabling symptom;Disease;efficacy evaluation;Excitatory Synapse;experience;Funding;Genes;Genetic;Genetic Polymorphism;Genetic study;genome wide association study;Goals;Hippocampus;Human Genetics;Impaired cognition;improved;In Vitro;in vivo;insight;Interneurons;Learning;Light;Long-Term Potentiation;Mediating;Memory;metabotropic glutamate receptor 3;metabotropic glutamate receptor 5;Metabotropic Glutamate Receptors;Modeling;Molecular;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;Neurons;neuropsychiatric disorder;Neurotransmitter Receptor;new therapeutic target;novel;optogenetics;Patients;Pattern;Performance;Pharmaceutical Preparations;pharmacologic;Phencyclidine;Play;Population;positive allosteric modulator;postsynaptic;preclinical study;Prefrontal Cortex;Pyramidal Cells;receptor;Receptor Signaling;Regulation;response;Rodent;Rodent Model;Role;Schizophrenia;Series;Signal Transduction;Somatostatin;Symptoms;Synapses;Synaptic plasticity;System;Testing;tool;transmission process

PROJECT_TITLE: Regulation of Signaling by mGluR5

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness;Stroke;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The depression-executive dysfunction syndrome after stroke is common, chronic, and disabling. The proposed study will evaluate the efficacy and target engagement of a digital therapeutic that targets the executive control network by training rapid multitasking, combined with metacognitive coaching to improve awareness of deficits and transfer of training gains. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, may support the use of the intervention to improve co-occurring cognitive and mood dysfunction after stroke.

PI_NAMEs: JAYWANT, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;affective disturbance;Aftercare;Anterior;anti-depressive agents;Attention;Awareness;Brain;brain based;Brain Injuries;career;career development;Chronic;Chronic disability;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive rehabilitation;cognitive testing;cognitive training;Collaborations;comorbidity;Control Groups;daily functioning;Data;Data Analytics;Depressed mood;depressive symptoms;design;Digit structure;digital intervention;digital treatment;disability;Disabling;Educational workshop;efficacious treatment;efficacy evaluation;Executive Dysfunction;executive function;experience;functional improvement;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Goals;Grant;group intervention;Impaired cognition;improved;Individual;International;Intervention;Investigational Therapies;K-Series Research Career Programs;Knowledge;Left;Manuscripts;Measures;Mental Depression;Mentors;Mentorship;Modality;Modeling;Montgomery and Asberg depression rating scale;Mood Disorders;multitask;neuroimaging;neuropsychiatry;Neurosciences;novel;older adult;Participant;Patient Self-Report;Patients;Performance;performance based measurement;personalized intervention;post intervention;post stroke;post stroke cognitive impairment;post stroke depression;Preparation;programs;Psychological Transfer;Randomized;remote delivery;remote intervention;Research;Research Personnel;Research Proposals;Rest;Role;Self Perception;Short-Term Memory;side effect;skills;Social Functioning;Standardization;Stroke;stroke patient;stroke rehabilitation;stroke survivor;symposium;Syndrome;targeted treatment;Testing;therapeutic target;therapy design;Time;Training;Treatment Efficacy;treatment optimization;virtual;Writing

PROJECT_TITLE: Efficacy and target engagement of a digital intervention to improve the depression-executive dysfunction syndrome after stroke


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will identify the exact genomic locations of DNA lesions that occur endogenously during aging as well as those induced by common environmental carcinogens and anti-cancer compounds, and then characterize the factors that influence damage removal at these same sites. The data obtained through this work will provide genome-wide single-nucleotide resolution DNA damage- and repair-platforms that will be widely used by researchers in the fields of DNA damage, repair, and mutagenesis as such contributes to the efforts of a holistic approach to carcinogenesis and chemotherapy. Thus, this project is relevant to NIH’s mission to understand how DNA adducts contribute to human carcinogenesis and affect cancer treatments.

PI_NAMEs: SANCAR, AZIZ  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: adduct;Affect;Aflatoxins;Age;Aging;anti-cancer;Antineoplastic Agents;Aromatic Polycyclic Hydrocarbons;Aspergillus;base;Benzo(a)pyrene;Cancer Etiology;cancer therapy;carcinogenesis;Carcinogens;cell injury;Cells;Chemicals;chemotherapy;cigarette smoke;Cisplatin;Coal Tar;Colorectal Cancer;comparative;consumer product;Data;design;Detection;Development;Diagnosis;Diethylnitrosamine;Disease;DNA;DNA Adducts;DNA analysis;DNA Damage;DNA lesion;DNA mapping;DNA Repair;DNA Repair Enzymes;DNA Sequence;Effectiveness;environmental carcinogenesis;Environmental Carcinogens;Excision;Experimental Animal Model;Experimental Models;Fluorenes;Food;Genome;Genome Mappings;genome-wide;genomic locus;genomic predictors;Genomics;glycosylation;Goals;holistic approach;Human;Human Cell Line;Human Genome;improved;in vivo;Industrial Waste;innovation;Knowledge;Laboratories;Link;Location;Malignant Neoplasms;Mammalian Cell;mammalian genome;Maps;Meat;Melphalan;metastatic colorectal;Methods;Mission;Modeling;mouse model;Mus;Mutagenesis;Mutagens;novel;Nucleotide Excision Repair;Nucleotides;Organ;Outcome;oxidation;oxidative damage;Pathogenicity;Patients;Positioning Attribute;pre-clinical;Predisposition;prevent;Prevention strategy;Primary carcinoma of the liver cells;programs;Public Health;Regimen;repair enzyme;repaired;Research;Research Personnel;Resolution;Role;side effect;Site;Source;Surgical incisions;System;Technology;Therapeutic;Therapeutic Effect;Time;Tissues;Tobacco smoke;tool;ultraviolet damage;United States National Institutes of Health;whole genome;Work;Xenograft procedure

PROJECT_TITLE: DNA Adduct Detection and Repair in Mammalian Cells

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Despite modern combination therapies, T-cell lymphoma (TCL) continues to have high rates of refractory disease and early relapse due to escape from immunosurveillance. Although TCL cells carry alterations that protects them from phagocytosis, their identification and relevance is poorly understood. This proposal utilizes integrative genomic and proteomic approaches to investigate mechanisms responsible for resistance to phagocytosis in TCL and develop strategies for their therapeutic targeting, thus providing significant impact for a wide variety of malignancies beyond TCL.

PI_NAMEs: JAIN, SALVIA  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adult;Advisory Committees;Affect;antagonist;anti-CD20;Anti-CD47;Antibodies;Antigen Presentation;Antitumor Response;Area;Award;B-Cell Lymphomas;Binding;Biology;Blocking Antibodies;Blood;C57BL/6 Mouse;cancer cell;Cancer Center;cancer immunotherapy;career;career development;CD47 gene;CD47-SIRPα;CD47-SIRPα blockade;Cell Line;Cells;Cellular biology;Child;Clinical;clinical care;clinical training;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complement;Computational Biology;Cutaneous;Cytoskeleton;Dana-Farber Cancer Institute;Data Set;Dedications;defined contribution;Dendritic cell activation;Dendritic Cells;Dependence;design;Development;differential expression;Early Therapeutic-Clinical Trials Network;Eating;efficacy evaluation;engineered T cells;Engraftment;Ensure;Environment;experience;Focus Groups;Foundations;Future;Genomics;Goals;Guanosine Triphosphate Phosphohydrolases;Hematologist;Hematology;Heterogeneity;Human;IgG Receptors;IgG1;Immune;Immunity;Immunocompetent;Immunologic Surveillance;Immunology;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;in vivo;Inflammasome;Integrins;International;Investigational Therapies;Israel;Jurkat Cells;Ki-1 Large-Cell Lymphoma;Knock-out;Laboratories;Lead;Lymphoma;Lymphoma cell;Macrophage;Macrophage-1 Antigen;Malignant Neoplasms;Mediating;Medical center;Mentors;Modeling;Modernization;Molecular;Monoclonal Antibodies;mouse model;Multi-Institutional Clinical Trial;Mus;neoplastic cell;next generation;novel;Orphan;Outcome;Patients;Peripheral;Phagocytes;Phagocytosis;Phagocytosis Induction;pre-clinical;Predisposition;prevent;programs;Proteins;Proteome;Proteomics;PTPNS1 gene;receptor;recruit;Refractory;Refractory Disease;Regimen;Relapse;Reporting;Research;Research Personnel;Research Proposals;Resistance;resistance mechanism;Resources;response;Rest;rituximab;Sampling;Signal Pathway;Signal Transduction;single cell sequencing;Solid;Structure;Surface;SYK gene;Systems Biology;T-Cell Lymphoma;T-Lymphocyte;Therapeutic;therapeutic target;Time;Training;transcriptome;transcriptome sequencing;Transgenic Organisms;Translational Research;treatment response;Tumor Burden;Tumor-associated macrophages;Work

PROJECT_TITLE: Dissecting mechanisms of resistance underlying CD47-SIRPα inhibition in T-cell lymphomas

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: WASHINGTON

ORG_NAME: U.S. DEPT/VETS AFFAIRS MEDICAL CENTER

ORG_STATE: DC

PHR: Project Narrative Fatigue is highly prevalent in individuals following severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infection which can persists for weeks to months. Veterans experiencing the chronic presence of fatigue following SARS-CoV-2 infection may be at risk for experiencing increased fatigability when engaging in physical activity. Skeletal muscle weakness, reduced oxygen extraction, and reduced affective responses to activity may contribute to increased fatigability following SARS-CoV-2 infection. Home-based exercise is a safe and accessible treatment option for addressing fatigability in Veterans recovering from SARS-CoV-2. Importantly, the findings of this project could be applied across numerous Veteran clinical populations experiencing increases in fatigue and fatigability.

PI_NAMEs: GOLLIE, JARED M. (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affective;Anxiety;appropriate dose;Atrophic;Award;Awareness;base;Chronic;Clinical;Clinical Trials;combat;Communities;COVID-19 pandemic;Data;design;Dose;Effectiveness;Exercise;exercise program;Exhibits;experience;Extensor;Fatigue;feasibility trial;Feeling;Fiber;functional outcomes;Goals;Health;health related quality of life;Home;improved;Individual;insight;Isometric Exercise;Knee;Measures;Mental Depression;Metabolic dysfunction;Motor;Muscle;Near-Infrared Spectroscopy;neurobehavioral;Neurobiology;neuromuscular;novel;Oxygen;patient population;Patients;Performance;Persons;Physical activity;Physical Exercise;Physiological;Population;post SARS-CoV-2 infection;post-COVID-19;Prevalence;Property;psychologic;Quarantine;Randomized;Rehabilitation therapy;remote delivery;Reporting;resistance exercise;response;Risk;safety and feasibility;SARS-CoV-2 infection;sedentary lifestyle;Severities;Skeletal Muscle;skeletal muscle weakness;Symptoms;Testing;vastus lateralis;Veterans

PROJECT_TITLE: Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Malaria infection in humans, caused by Plasmodium species parasites, is a major global health challenge causing over 400 million deaths worldwide every year, the majority being young children. Despite recent licensure of the first ever malaria vaccine, its low efficacy and recent reports of drug resistance to frontline artemisinin-based therapies in Africa add additional urgency to the pressing need for new druggable targets that that are essential for the parasite lifecycle and with known mechanisms of action and which thus have the potential to stop parasite infection. Our proposal provides a fuller understanding of the function of three essential Plasmodium myosins as druggable targets, defines the effect of small molecule inhibitors on one of these essential myosins, and allows us to discover fundamental insights into malaria parasite cell biology.

PI_NAMEs: TRYBUS, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Actins;Actomyosin;Africa;Age;Artemisinins;ATP phosphohydrolase;Binding;Binding Sites;Biological;Biological Assay;Cell division;Cell Physiology;Cells;Cellular biology;Cessation of life;Child;Complex;conditional knockout;Cryoelectron Microscopy;Crystallization;Culicidae;Development;Drug resistance;druggable target;Erythrocytes;Foundations;Future;Genetic;Genetic study;global health;Goals;Heart;Human;imaging study;In Vitro;in vivo;inhibitor;insight;Invaded;Investigation;Kinetics;Licensure;Life Cycle Stages;Light;live cell imaging;Malaria;malaria infection;Malaria Vaccines;Molecular;Motility;Motion;Motor;mutant;Myosin ATPase;Myosin Type V;myosin VI;N-terminal;new therapeutic target;novel;optic trap;optical traps;Organelles;Parasites;Parasitic infection;Pathogenesis;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Plasmodium;Plasmodium falciparum;Play;Positioning Attribute;Power stroke;Process;Property;Reporting;Research;Role;Sexual Development;small molecule inhibitor;Sporozoites;Structure;superresolution imaging;Tissues;tool;trafficking;Vaccines;virtual;Virulent;Work;X-Ray Crystallography

PROJECT_TITLE: Structure and function of the Plasmodium myosin XIV-actin glideosome.

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Albany

ORG_NAME: REGENERATIVE RESEARCH FOUNDATION

PHR: PROJECT NARRATIVE Significant progress in identifying genes that accelerate or slow Alzheimer disease now leads to a critical question, how do these genes act to alter disease progression? We will focus our studies on the impact of these genes on brain vascular pathology which is present in almost all Alzheimer’s disease patients and has been shown to be an early driver of loss of brain function. Because hundreds of genes are potentially involved, we will use large-scale cutting-edge gene editing and screening methods for initial analysis. This will create a prioritized list of genes for focused functional studies in human stem cell models and mouse models. The goal is to identify early events leading to vascular pathology that can be targeted to combat Alzheimer’s disease.

PI_NAMEs: HARARI, OSCAR ;KAMPMANN, MARTIN ;KARCH, CELESTE MARIE;PUMIGLIA, KEVIN M;TEMPLE, SALLY  (contact);ZULOAGA, KRISTEN LEANNE

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adeno-associated viral vector;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Architecture;ATAC-seq;Autopsy;Bioinformatics;Biological;Biological Models;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;Brain;brain control;brain endothelial cell;Brain Pathology;Brain region;Candidate Disease Gene;Cell Communication;Cell Line;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Cerebral Amyloid Angiopathy;cerebral vascularization;cerebrovascular;Cerebrovascular Circulation;cerebrovascular pathology;Cerebrovascular system;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Code;cognitive change;cognitive function;Collaborations;Collection;combat;comorbidity;Complex;Coupling;CRISPR interference;CRISPR-mediated transcriptional activation;Data;data integration;Data Set;data sharing;Dementia;dementia risk;Deposition;Development;Disease;Disease Progression;diverse data;Early identification;Elements;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Event;Exhibits;functional genomics;Gene Expression;Genes;Genetic Risk;genetic variant;genome wide association study;Genomics;Goals;Guide RNA;Human;human induced pluripotent stem cells;human stem cells;Impairment;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;Interdisciplinary Study;Intervention;Investigation;Knock-in;Knowledge;Lead;Libraries;Ligands;Light;Link;Maps;member;men;Metabolic Diseases;Methods;Microvascular Dysfunction;Modality;Modeling;Molecular;monolayer;mouse model;multidisciplinary;Mus;Nerve Degeneration;Neurons;neuropathology;neurovascular;Nuclear;Organoids;Outcome;Pathologic;Pathology;Pathway interactions;Perfusion;Pericytes;Phenotype;polygenic risk score;Population;pre-clinical;prime editing;prime editor;Production;protein expression;receptor;Resources;Risk;risk variant;RNA library;Sampling;screening;sex;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;stem cell model;synaptogenesis;System;tau Proteins;Testing;therapeutic development;three-dimensional modeling;transcriptome sequencing;transcriptomics;Transgenic Organisms;translating ribosome affinity purification and RNA-sequencing;translatome;Untranslated RNA;Vascular Diseases;Woman

PROJECT_TITLE: Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Microbiome;Rare Diseases;Urologic Diseases

PHR: Despite evidence that the gut microbiome is an important modulator of oxalate metabolism, its role in the pathophysiology of enteric hyperoxaluria (EH) has not been well studied. In this proposal, our goal is to establish the effect of oxalobiome on urinary oxalate levels in patients with EH and explore it mechanistically in different mouse models.

PI_NAMEs: NAZZAL, LAMA  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Address;Adult;Affect;Animal Model;Bacteria;bench-to-bedside translation;Biological;Biology;Calcium Oxalate;candidate identification;Clinical;Clinical Research;clinically significant;cohort;Colon;Communities;Computer Analysis;Computing Methodologies;Culture Media;Data;design;Development;Diagnosis;Diet;Enrollment;Enteral;Evaluation;Excretory function;experience;Functional disorder;Funding;Gastric Bypass;Gastrointestinal Diseases;Genes;Germ-Free;Goals;Growth;gut bacteria;gut microbiome;Health Care Costs;Human;human subject;Hyperoxaluria;in vivo;Individual;Inflammatory Bowel Diseases;Intestines;Kidney;Kidney Calculi;Knowledge;Mammals;Measures;member;Metabolic;Metabolism;metagenomic sequencing;Metagenomics;metatranscriptomics;Microbe;microbial community;microbiome;microbiome analysis;microbiome therapeutics;Modeling;mouse model;Mus;Nephrocalcinosis;Nephrolithiasis;novel;Organism;Oxalates;Oxalobacter formigenes;Patients;Permeability;Play;Population;Populations at Risk;prevent;Rattus;Recurrence;Research Design;restoration;Risk;Rodent Model;Role;Series;Severities;stool sample;Structure;Supplementation;Technology;Testing;therapeutic target;United States;urinary

PROJECT_TITLE: Gut-kidney axis in enteric hyperoxaluria

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE It is well established that individuals exposed to trauma are at increased risk for both Alcohol Use Disorder (AUD) and post-traumatic stress disorder (PTSD); moreover, there is a high rate of comorbidity of these two disorders. The vast majority of this research has been conducted in adults. In this proposal, we will identify biological predictors of AUD and/or PTSD including genomics, epigenetics, inflammation and psychophysiology in the immediate aftermath of trauma in order to determine which adolescents are at risk to develop these devastating disorders.

PI_NAMEs: NEMEROFF, CHARLES B (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: accelerated epigenetic aging;Accident and Emergency department;Acoustics;Acute;Address;Adolescence;Adolescent;Adult;age acceleration;Alcohol dependence;alcohol risk;alcohol use disorder;Anti-Inflammatory Agents;Autonomic nervous system;Biological;Biological Markers;biosignature;Blood;Brain;Central Nervous System;Cessation of life;Child;Clinic;Clinics and Hospitals;Cognitive;cohort;Collection;comorbidity;cytokine;Data;Data Set;design;Development;Diagnosis;Disease;DNA Methylation;drinking onset;DSM-V;Early Intervention;early onset;Electrocardiogram;Electromyography;Emotional;Enrollment;epidemiology study;Epigenetic Process;epigenomics;Exhibits;Exposure to;Family Study;follow-up;Galvanic Skin Response;Genetic Risk;genomic predictors;Genomics;Heart Rate;heart rate variability;Heritability;high risk;Hospitals;indexing;Individual;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon Type II;longitudinal, prospective study;Machine Learning;Measurement;Measures;Medical;Medical center;Modeling;molecular marker;Neurobiology;novel;Outcome;Pathogenesis;Pathway interactions;Patients;pediatric trauma;Phenotype;Physiological;polygenic risk score;post-trauma;Post-Traumatic Stress Disorders;predictive marker;predictive tools;prospective;Prospective Studies;Psychophysiology;Reflex action;Research;response;Risk;Risk Factors;risk prediction model;RNA;Role;Sampling;sexual violence;Site;socioeconomics;Startle Reaction;Statistical Models;statistics;Stress;Techniques;Texas;Time;Tissues;TNF gene;tool;transcriptomics;Trauma;trauma centers;trauma exposure;Twin Studies;Universities;Untranslated RNA;Validation;Work

PROJECT_TITLE: Prediction of Alcohol Use Disorder and PTSD After Trauma in Adolescents

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: This work will enhance the understand the role of tumor niche in B cell lymphomas, while at the same time establish a biomaterials-based modular ex vivo organoid platform with design flexibility for lymphoma subtypes. Mechanisms from the proposed research will increase “predictive power” of pre-clinical small molecule inhibitors for targeted therapies, provide potential biomarkers for correlative studies in clinical trials, and provide clues towards mechanisms that might induce resistance to inhibitors by more faithfully representing patient biological features and creating relevant treatment regimens.

PI_NAMEs: SINGH, ANKUR  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: activated B cell like;Agammaglobulinaemia tyrosine kinase;Agonist;antagonist;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;Biocompatible Materials;Biological;Bypass;cancer cell;Cells;Chronic;Clinical;clinical investigation;Clinical Trials;combinatorial;Complex;cooperative study;Correlative Study;Data;defined contribution;Dependence;design;Development;Diffuse Large-Cell Lymphoma;Dose;Drug Exposure;Epigenetic Process;Extracellular Matrix;Extranodal;Feedback;flexibility;fluid flow;Genetically Engineered Mouse;Growth;Heterogeneity;Human;Hydrogels;Hyperactivity;Immune;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Integrins;Investigational Therapies;kinetic model;large cell Diffuse non-Hodgkin's lymphoma;Ligands;Link;Liquid substance;lymph nodes;Lymphatic;Lymphoid;lymphoid neoplasm;Lymphoid Tissue;Lymphoma;Malignant - descriptor;Measures;Mediating;Mediator;Microfluidics;Molecular;Morphology;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Mutate;Mutation;neoplastic cell;Organoids;Outcome;Pathway interactions;patient subsets;Patients;personalized medicine;Pharmaceutical Preparations;Physiological;potential biomarker;pre-clinical;Proliferating;protein activation;Proteins;Publishing;Receptor Activation;Receptor Signaling;Regulation;Relapse;Reporting;Research;Research Project Grants;Resistance;response;Role;Sampling;Scheme;Signal Pathway;Signal Transduction;small molecule inhibitor;Somatic Mutation;Source;Structure of germinal center of lymph node;targeted treatment;Technology;Therapeutic;therapeutic target;Time;Tissue Model;Tissues;Titrations;TLR1 gene;Toll-Like Receptor Pathway;Toll-like receptors;Translations;Treatment Efficacy;Treatment Protocols;tumor;tumor microenvironment;Tumor Promotion;Work;Xenograft procedure

PROJECT_TITLE: Lymphoid Experimental Therapeutics Platform to Study Cooperative Signaling inHuman Lymphomas

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: • REASEARCH NARRATIVE • Renal cell carcinoma (RCC), the 8th most common form of adult cancer in the US, is in need of novel therapeutic strategies to overcome resistance to existing treatments. Our preliminary studies have revealed that deregulation of the Hippo-YAP/TAZ pathway represents a major molecular hallmark across most subtypes of RCC, and is a key mechanism used by tumor cells to maintain their transcriptional and metabolic homeostasis. Employing patient-derived RCC tumor models and clinically viable inhibitors, our study will establish the therapeutic potential and mechanisms of actions for YAP/TAZ-based therapies in RCC.

PI_NAMEs: YI, CHUNLING  (contact)

PROJECT_TERMS: Adult;Affect;antitumor effect;ATAC-seq;Automobile Driving;Bromodomains and extra-terminal domain inhibitor;Cell Nucleus;Cessation of life;Clinic;Clinical;clinical translation;Collaborations;Collection;Combined Modality Therapy;Complex;Data;Dependence;Disease;Dose;efficacy study;Epigenetic Process;epigenomics;Flow Cytometry;functional genomics;Genes;Genetic;Genetic Transcription;Genomic approach;Growth;high-throughput drug screening;Homeostasis;Human;immune cell infiltrate;Immune checkpoint inhibitor;improved;In Vitro;in vivo;inhibitor;innovation;insight;kidney cell;Malignant Epithelial Cell;Malignant Neoplasms;MAP Kinase Gene;mechanical signal;MEKs;Metabolic;Metastatic Renal Cell Cancer;Modeling;Molecular;Mutate;Mutation;Myeloid-derived suppressor cells;neoplastic cell;new therapeutic target;next generation;novel therapeutic intervention;Nutrient;Oncogenic;Oncoproteins;Oral;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;predictive marker;Primary Neoplasm;Protein Dephosphorylation;Publishing;recruit;Renal Cell Carcinoma;Reproducibility;Resistance;response;Role;Scaffolding Protein;screening;Screening procedure;Signal Transduction;small molecule;synergism;T-Cell Activation;Techniques;Technology;Testing;Therapeutic;therapy resistant;Tissues;Toxic effect;transcription factor;transcriptome sequencing;Treatment Efficacy;Treatment outcome;tumor;tumor growth;Tumor-infiltrating immune cells;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Strategies to Disrupt Oncogenic Transcription in RCC Tumors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: UNION

ORG_NAME: PROKARYOTICS, INC.

ORG_STATE: NJ

PHR: Narrative Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) are a major cause of bloodstream infections in the hospital and in the community. Indeed, MRSA has recently been reported as the second leading cause of mortality by drug-resistant bacterial pathogens in the United States. This project will develop a new strategy to thwart these deadly infections.

PI_NAMEs: ROEMER, TERRY  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Anabolism;analog;Antibiotics;Award;Bacterial Infections;bactericide;beta-Lactams;Binding Proteins;Biological;Biological Availability;candidate selection;Canis familiaris;Chemosensitization;Clinical;Colony-forming units;Communities;comparative efficacy;Daptomycin;Data;Development;Dose;Drug Interactions;Drug Kinetics;Drug resistance;Drug usage;Effectiveness;efficacy study;Enzyme Inhibitor Drugs;Enzymes;Formulation;Fractionation;Genes;Genus staphylococcus;Goals;Gram-Positive Bacterial Infections;Grant;Hemolysis;Hepatocyte;HepG2;Hospitals;Human;improved;In Vitro;in vivo;indexing;Infection;International;Intestines;Lactams;Lead;Linezolid;Liquid substance;Lytic;Mediating;Metabolic;Metabolism;Methicillin;Methicillin Resistance;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Modeling;Molecular;mortality;Mus;Names;No-Observed-Adverse-Effect Level;novel;novel therapeutics;opioid epidemic;Oral;Oral Administration;Oxazolidinones;pathogenic bacteria;Pathway interactions;Patients;Pattern;Penicillin-Binding Proteins;Pharmaceutical Preparations;Pharmacodynamics;Phase;Plasma Proteins;pre-clinical;pre-clinical assessment;Predisposition;programs;Property;Rattus;Regimen;Reporting;Resistance;resistance frequency;Risk;Safety;scale up;Sepsis;Small Business Innovation Research Grant;Solubility;standard of care;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus epidermidis;synergism;Taro Vegetable;Teichoic Acids;Testing;Therapeutic Index;Thigh structure;Toxic effect;Toxicology;United States;Vancomycin;Work

PROJECT_TITLE: Development of a PO-administered beta-lactam-tarocin combination agent to treat methicillin susceptible and methicillin resistant Staphylococci

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Nutrition

ORG_CITY: DAVIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Chemoenzymatic construction of synthetic human milk oligosaccharide (HMO) glycome Efficient and innovative methods will be developed and related enzymes will be identified for target-oriented chemoenzymatic synthesis of human milk oligosaccharides (HMOs) in a systematic manner. The resulting compounds are important standards for analysis, probes to identify HMO-binding proteins, and reagents to explore the multifaceted applications of HMOs as infant formula additives, potential nutraceuticals and therapeutics. The chemoenzymatic synthetic process is programmable, can be adapted for automation, and readily scalable for large-scale production of HMOs in the future.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Atlases;Automation;Binding Proteins;Breastfed infant;Carbohydrates;Chemicals;cost effective;design;Discipline of Nursing;Disease;Economics;Engineering;Enzymes;Escherichia coli;Fermentation;Fucose;Future;glycosylation;glycosyltransferase;Health;Human Milk;human milk oligosaccharides;improved;In Situ;Individual;Infant formula;Infection;innovation;Isomerism;Lactation;Lactose;large scale production;Libraries;Life;Maps;method development;Methods;Milk;Monosaccharides;nucleoside triphosphate;nursing mothers;Nutraceutical;Polysaccharides;Process;Production;Reagent;Role;Route;scale up;Sialic Acids;sialylation;Site;Source;Speed;Structure;Substrate Specificity;sugar nucleotide;Therapeutic;tool;user-friendly;Vertebral column

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE There is an unmet clinical need to develop novel therapeutic agents for the treatment of the head and neck squamous cell carcinoma (HNSCC). Thus, this application's primary goal is to discover the fundamental vulnerabilities of HNSCC for the development of mechanism-based therapeutic drugs or strategies.

PI_NAMEs: OGRETMEN, BESIM  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: advanced disease;analog;cancer cell;carcinogenesis;Cell Death;cell growth;Cell Survival;Cell Therapy;Cells;Ceramides;Cessation of life;Cisplatin;Clinic;Clinical;Coin;Complex;Data;Defect;design;Development;dihydroceramide desaturase;Disease;Dynamin;Endoplasmic Reticulum;Enzymes;experimental study;Generations;Goals;Head and Neck Squamous Cell Carcinoma;Head and neck structure;HPV negative;Larynx;Light;Malignant Neoplasms;Mediating;Membrane;Metabolic;Metabolism;Microtubules;Mitochondria;mouth squamous cell carcinoma;Mucous Membrane;Names;novel;novel therapeutics;oral HPV-positive head and neck cancers;Organoids;Patients;Pharmaceutical Preparations;Pharyngeal structure;PINK1 gene;Positioning Attribute;Process;Production;protein activation;Proteins;Reactive Nitrogen Species;reconstitution;Regulation;Research;response;Ribosomes;Role;Scientist;Selenium;Signal Transduction;Sirolimus;Sodium Selenite;Sphingolipids;Stimulus;Stress;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;trafficking;Translating;tumor;Tumor Suppression;United States

PROJECT_TITLE: Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE - OVERALL Alzheimer's disease (AD) is one of the most urgent health care concerns facing the United States. The Alzheimer’s Disease Research Centers (ADRCs) funded by the NIA provide a national network of resources and researchers aiming to discover the causes and treatments of this disease and related dementias. The Northwestern ADRC is part of this network and serves a leadership role in research on the causes and treatments of AD and related dementias and also on the factors that promote unusually successful brain aging.

PI_NAMEs: VASSAR, ROBERT J (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Accreditation;Address;Administrator;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Area;Autopsy;Award;beneficiary;Biological Markers;Biology;Biometry;Blood;brain tissue;Businesses;Clinical;clinical diagnosis;Clinical Investigator;Cognitive aging;cognitive neuroscience;cohort;Collaborations;Consultations;Data;data exchange;data management;Dementia;design;Development;diagnostic criteria;Disease;DNA;Early Diagnosis;Education;education research;Educational Status;Ensure;Etiology;Extramural Activities;Faculty;Family;Fellowship;Frontotemporal Lobar Degenerations;Funding;Goals;Grant;Healthcare;Heterogeneity;Human Resources;Image;imaging biomarker;Individual;innovation;Institution;interest;Intervention;Investments;Laboratories;Leadership;Life;member;Microglia;middle age;Modality;multidisciplinary;multimodal neuroimaging;Names;Nerve Degeneration;neuroinflammation;neuropathology;Neuropsychology;Nonpharmacologic Therapy;novel;outreach;Parents;Participant;participant retention;Pathology;Pathway interactions;Patient Recruitments;Patients;Plasma;Play;Positron-Emission Tomography;Primary Progressive Aphasia;programs;protein TDP-43;recruit;Research;Research Personnel;Research Priority;Research Support;Resources;responsible research conduct;Risk Factors;Role;Scientist;Slide;Standardization;statistics;Syndrome;tau Proteins;Time;Tissue Sample;Tissues;Training;Training and Education;Training Programs;translational approach;Translational Research;Underrepresented Populations;Underserved Population;United States;Universities;Work

PROJECT_TITLE: NORTHWESTERN Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Adopted;Adoption;Advocate;Alzheimer's Disease;Animal Welfare;beneficiary;Biological Markers;Caregivers;Chicago;Cities;Clinical Trials;Collaborations;Contracts;Data;Dementia;Development;Education;Ensure;Faculty;Frontotemporal Lobar Degenerations;Funding;Goals;Health Insurance Portability and Accountability Act;human subject;Illinois;innovation;Institutional Review Boards;Lead;Leadership;meetings;molecular imaging;Monitor;operation;Parents;Patients;Policies;Progress Reports;recruit;Research;Research Priority;Resource Sharing;Resources;responsible research conduct;Role;Running;Sampling;structural imaging;Translational Research;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Administrative Core


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Class switch recombination and somatic hypermutation are essential for B cell-mediated immunity. Defects in these secondary diversification reactions lead to immunodeficiency syndromes in humans. The goal of this application is to understand the mechanisms by which the central effector of both processes, AID, is regulated.

PI_NAMEs: CHAUDHURI, JAYANTA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;Antigen Presentation;Antigens;B lymphoid malignancy;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Base Pairing;Binding;cancer type;Cell Death;Cells;Cellular Immunity;Chromatin;Chromosomal translocation;Cytidine Deaminase;Deamination;Defect;Deoxycytidine;Deoxyuridine;DNA;DNA Double Strand Break;DNA Structure;Double Strand Break Repair;Exons;experimental study;Failure;Funding;Future;G-Quartets;gene correction;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;genome integrity;genome-wide;Goals;Growth;Guanine;Guide RNA;Heavy-Chain Immunoglobulins;Human;Humoral Immunities;humoral immunity deficiency;Hyper IgM syndrome type 2;IGH@ gene cluster;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunologic Deficiency Syndromes;Induced Mutation;interest;Ions;Knock-in Mouse;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lead;Lesion;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mature B-Lymphocyte;Mediating;Memory B-Lymphocyte;Molecular Conformation;Mus;Mutate;Mutation;novel;Oncogenic;Pathologic;Patients;Physiological;Plasma Cells;preservation;Process;Proteins;Reaction;recruit;Residencies;response;Rest;RNA;RNA Splicing;Role;Structure;Structure of germinal center of lymph node;Testing;Text;Transcript

PROJECT_TITLE: RNA-directed targeting of AID in immunity and cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-E(02)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Depression;Endocannabinoid System Research;Genetics;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: RELEVANCE (See instructions): The Marchigian Sardinian alcohol-preferring (msP) rats represent an unique rat  model in which genetic selection for high alcohol preference has led to co-segregation of elevated  sensitivity to stress and anxiety. The goal of this project is to provide a systematic investigation at the  molecular, neurochemical and behavioral levels of the impact of these heritable factors and biological  mechanisms in the etiology of anxiety and alcohol drinking behavior. These studies may help identify  biological targets for the development of pharmacological treatment for alcoholism and the frequent co-occurrence anxiety related disorders, such as post-traumatic stress disorder (PTSD).

PI_NAMEs: ROBERTO, MARISA  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: 2-arachidonylglycerol signaling;Adrenal Cortex Hormones;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol preferring rats;alcohol use disorder;Alcoholism;alcoholism therapy;Alcohols;Amygdaloid structure;Anxiety;anxiety-related disorders;behavior test;Behavioral;Biological;Brain;Cell Nucleus;Chronic;CNR1 gene;Collaborations;conditioned fear;Corticotropin-Releasing Hormone;CRF receptor type 1;Data;Dependence;Development;Disease;drinking;drinking behavior;dysphoria;Electrophysiology (science);Emotional;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Environmental Risk Factor;Enzyme Inhibitor Drugs;Enzymes;Etiology;Extinction;fatty acid amide hydrolase;Fright;Funding;gamma-Aminobutyric Acid;gene environment interaction;Genetic;genetic selection;Genotype;genotypic sex;Glutamates;Goals;Heavy Drinking;Heritability;high throughput analysis;Human;Hypersensitivity;Immunoprecipitation;insight;Instruction;Investigation;Medical;Mental Depression;Methods;Modeling;Molecular;Molecular Biology;Mood Disorders;negative affect;negative emotional state;neuroadaptation;neurochemistry;novel;novel therapeutics;overexpression;Peptides;Performance;pharmacologic;Pharmacological Treatment;Phenotype;Post-Traumatic Stress Disorders;Predisposition;preference;Proteins;Proteome;Rattus;Recreation;Relapse;Research;response;Role;segregation;Sex Differences;Shapes;Signal Transduction;Site;Stress;Stress and Coping;Structure;Symptoms;System;Testing;Therapeutic Agents;Time;transmission process;Treatment Efficacy;Up-Regulation;Wistar Rats

PROJECT_TITLE: Gene-environment interaction: the brain CRF system in alcohol preferring msP rats

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on providing tools and educational material for evaluating and improving the psychometric characteristics of psychophysiological measurements and other trial-wise scores. The project will develop, demonstrate, and disseminate tools to optimize three paradigms for recording event-related potentials (ERPs), time-frequency electroencephalography (EEG), facial electromyography (EMG), and electrodermal activity (EDA) in depression and anxiety, and the developed software, the Psychophysiologist’s Reliability Analysis Toolbox (PsyRAT), will be made openly available to facilitate the application of generalizability theory to novel measures and paradigms. The proposed research is relevant to NIMH’s Research Domain Criteria (RDoC) initiative, which emphasizes dimensional relationships that cut across traditional diagnostic boundaries to foster a better understanding, diagnosis, and treatment of mental illness.

PI_NAMEs: CLAYSON, PETER EUGENE (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Adoption;Anxiety;Attention;Behavior;behavior measurement;Biological;Biological Markers;biomarker evaluation;biomarker performance;biomarker selection;Brain;candidate marker;Characteristics;Clinical;clinical biomarkers;Clinical Research;Clinical Trials;Code;Computer software;Data;data access;Decision Making;design;Development;Diagnosis;Diagnostic;Dimensions;E-learning;Educational Materials;Electroencephalography;Electromyography;Evaluation;Evaluation Studies;Event;Event-Related Potentials;experience;Face;Fostering;Frequencies;Functional Magnetic Resonance Imaging;Funding;Genomics;Goals;Guidelines;improved;Individual;Individual Differences;innovation;Length;Link;Measurement;Measures;Mental Depression;Mental disorders;Monitor;National Institute of Mental Health;neglect;neural;Neurosciences;novel;novel strategies;online tutorial;open source;open source tool;Outcome;Participant;Patient Self-Report;Persons;precision medicine;Procedures;Process;process optimization;Property;psychologic;Psychometrics;Psychopathology;Psychophysiology;Public Health;Reflex action;Reporting;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Resources;response;Rewards;Risk;Risk Estimate;software development;Source;Symptoms;System;Testing;theories;Time;tool;tool development;Training;user-friendly;Work

PROJECT_TITLE: PsyRAT: Extensible Open-Source Software for Applying Generalizability Theory to Assess Psychometric Reliability of Trial-Wise Scores and Optimize Tasks for RDoC

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]