NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: PROJECT NARRATIVE O6-methylguanine-DNA methyltransferase (MGMT) plays a prominent role in DNA adduct repair that limits the mutagenic and cytotoxic effect of alkylating agents. The goal of this research project is to apply biodegradable small-sized polymer for targeted delivery of DNA MGMT inhibitor with combination of TMZ and radiation therapy for real time monitoring of response to the treatment. Success in our study in preclinical animal tumor models should provide us with novel DNA inhibitors and methods to further develop clinical applications of such therapy options for the improved treatment of brain tumors.

PI_NAMEs: ALI, MESER M. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Affinity;Alcohols;Alkylating Agents;Alkylation;Amino Acids;Animals;Apoptotic;Binding;Biodistribution;Biological Availability;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;Brain Neoplasms;cancer cell;cancer therapy;Carbon;Cell Culture Techniques;Cells;chelation;Chemicals;Chemoresistance;Chlorotoxin;clinical application;Clinical Research;Combined Modality Therapy;Combretastatin A-4;Complex;Copper;Coupled;Curcumin;Cysteine;cytotoxic;cytotoxicity;Development;Diagnosis;Disulfides;Disulfiram;Ditiocarb;DNA;DNA Adducts;DNA Double Strand Break;DNA Repair;DNA Repair Enzymes;Dose;Drug Delivery Systems;Drug Targeting;Effectiveness;efficacy evaluation;Encapsulated;Engineering;Environment;Enzymes;extracellular;FDA approved;Formulation;fractionated radiation;Fractionated radiotherapy;Glioblastoma;Glioma;Goals;Hematology;Heterogeneity;hydroxypropyl-beta-cyclodextrin;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;Intravenous;Ligands;Magnetic Resonance Imaging;Malignant Glioma;MAPK8 gene;Mediating;Methods;Methyltransferase;MGMT gene;Modeling;Molecular;Monitor;Morphology;multicatalytic endopeptidase complex;nanoparticle delivery;neoplastic cell;novel;Oral;Oral Administration;overexpression;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;Physiological;Play;Polymers;pre-clinical;preclinical study;Prognosis;Prognostic Factor;Protein Methyltransferases;Proteins;radiation resistance;Radiation therapy;real time monitoring;receptor;Recurrent disease;repaired;Reporting;Research;Research Project Grants;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Role;Safety;Serum Proteins;Solubility;Specificity;standard of care;Stomach;success;System;targeted agent;targeted delivery;temozolomide;Testing;therapy resistant;Tissues;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Burden;tumor heterogeneity;Ubiquitin;Water;water solubility;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeted drug delivery system to overcome blood-brain barrier and therapeutic resistance to current standard of care in Glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Services;Kidney Disease;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE The goal of this Mid-Career Investigator Award in Patient Oriented Research is to provide support for mentoring and research in the study of cardiovascular disease and chronic kidney disease. Dr. Morgan Grams is a nephrologist and epidemiologist with broad expertise in applying quantitative clinical research methods to large data sources and a strong track record of successful mentorship. The K24 will allow Dr. Grams to expand her mentoring to ensure the next generation of patient-oriented researchers are able to take advantage of the ever-growing availability of health care data to answer clinically important questions in the field.

PI_NAMEs: GRAMS, MORGAN ERIKA (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;African American;American;American Heart Association;Atherosclerosis Risk in Communities;Award;Benefits and Risks;Big Data Methods;Biometry;Biostatistical Methods;Cardiology;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular Pathology;cardiovascular risk factor;Cardiovascular system;career;career development;Career Mobility;Chronic Kidney Failure;Clinical;clinical epidemiology;Clinical Medicine;clinical practice;Clinical Research;clinical risk;Clinical Trials;clinically relevant;college;Complement;computer science;Data;data management;Data Sources;design;Development;Discipline;Discipline of Nursing;Doctor of Philosophy;Educational Curriculum;Effectiveness;Electronic Health Record;End stage renal failure;Engineering;Ensure;Epidemiologic Methods;Epidemiologist;Epidemiology;Event;experience;Faculty;Funding;General Population;Goals;Guidelines;health care availability;Health system;Human Genetics;Hypertension;improved;Information Technology;Internal Medicine;Journals;K-Series Research Career Programs;Kidney Diseases;Knowledge;lecturer;Manuscripts;medical schools;Medical Students;medication safety;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Nephrology;next generation;Participant;Patient Care;patient oriented;patient oriented research;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pilot Projects;Population;post-market;pre-clinical;prevent;Prevention;Prevention strategy;Prognosis;programs;Public Health Schools;Publications;Publishing;recruit;Renal function;Research;Research Methodology;Research Personnel;Residencies;risk prediction;Safety;Societies;Talents;Time;Training;Translating;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Prevention and Treatment of Cardiovascular Disease in Patients with Chronic Kidney Disease: Patient-Oriented Research and Mentoring

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Infectious Diseases;Regenerative Medicine

ORG_CITY: Kampala

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: JOINT CLINICAL RESEARCH CENTER

PHR: Although antiretroviral drugs have revolutionized the management of HIV, they still need to be taken for life, new infections and deaths continue to occur the fast-track strategy to control the epidemic by 2030 may not be met. New tools are required to get the world on track to bring HIV infection under control in sub-Saharan Africa and globally and the most impactful advance would be development of an HIV cure using HIV gene therapy which is the frontrunner today but also in line with NIH priorities of research to develop next generation of HIV therapies and discovery of a cure for HIV/AIDS. A cure strategy that prevents reinfection would revolutionize HIV management, and constitute a onetime intervention with high impact on quality and quantity of life with phenomenal clinical, economic and social value.

PI_NAMEs: KITYO, CISSY  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Admission activity;Africa;Africa South of the Sahara;antiretroviral therapy;Cancer Center;Caring;Cell Therapy;Cells;Clinical Research;Clinical Trials;Collaborations;Consultations;Educational Curriculum;Educational workshop;Faculty;Focus Groups;Fred Hutchinson Cancer Research Center;gene therapy;Genetic Variation;Goals;graduate student;Health Personnel;HIV;HIV therapy;HIV vaccine;Host resistance;immunoreactivity;informant;innovation;Institution;interest;Interview;Joints;low and middle-income countries;meetings;Needs Assessment;Persons;Population Heterogeneity;Process;programs;prospective;recruit;Research;research and development;Research Training;Resources;Science;Scientist;Strategic Planning;success;Surveys;Teacher Professional Development;Technology;Training;Training Activity;Training Programs;Translational Research;Uganda;undergraduate student;United States National Institutes of Health;Universities;Virion;virtual;Writing

PROJECT_TITLE: Leveraging North-South Partnerships to Advance Cell and Gene Therapy Research Training for HIV in Uganda (C&GT-Uganda)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Physical Activity;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DE PAUL UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Making healthy decisions and engaging in healthy behaviors are important for public health broadly. The current project aims to examine social and emotional influences on health decision making and behavior in older and younger adults with a focus on physical activity and its consequences for mental, physical, and cognitive health. Results of this project will have useful policy and intervention implications for the public health sector.

PI_NAMEs: MIKELS, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adherence;Affect;Affective;Age;age difference;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;apolipoprotein E-4;Behavior;behavior change;Behavioral;behavioral outcome;Buffers;Cardiovascular system;Cognitive;cognitive function;Decision Making;dementia risk;Development;Elderly;Emotional;emotional factor;Emotions;Enrollment;Evaluation;evidence base;Exercise;exercise intervention;exercise program;experimental study;field study;Genes;Genetic Risk;Goals;Health;Health Benefit;health difference;Heterogeneity;Impaired cognition;improved;Influentials;innovation;insight;Intervention;Intervention Studies;Laboratories;laboratory experiment;late life;Light;Link;Maintenance;Measures;Mediating;Mental Health;Methods;Motivation;novel;older adult;Outcome;Participant;Personal Satisfaction;Persons;Physical activity;physical conditioning;Physiological;Play;Policies;Process;programs;Psyche structure;Public Health;Reaction;Recommendation;recruit;Research;response;Risk;Role;sedentary;social;social factors;social influence;Social Processes;Testing;theories;Theory of Change;Time;translational applications;Work;young adult

PROJECT_TITLE: Emotion, Aging, and Decision Making

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Through examination of the molecular mechanisms of chronic pain at anterior cingulate cortex, a major area involved in processing pain sensation in the brain, the research team aims to elucidate how our brain perceives pain and how this can be altered through changes in the function of an ion channel named acid-sensing ion channel 1a, or ASIC1a. The proposed research combines the complementary strengths of two laboratories using innovative and the state-of-the-art techniques. Chronic pain is a debilitating medical problem, affecting millions of people, to which current clinical therapy has only limited efficacy; the proposed project is expected to shed lights on new ways to treat chronic pain.

PI_NAMEs: ZHU, MICHAEL X (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;abuse liability;Acids;Adverse effects;Affect;Affective;AMPA Receptors;Animals;Anterior;Area;ASIC channel;Behavior assessment;Behavioral Assay;behavioral study;Binding;Biochemical;Biochemistry;Biological;Brain;Brain region;Cells;Cellular biology;Central Nervous System;central pain;Chemicals;China;Chinese;chronic pain;chronic pain management;cingulate cortex;Clinical;Collaborations;Development;Diffusion;Electrophysiology (science);Ethylmaleimide;excitatory neuron;experience;extracellular;Fiber;Genes;Goals;Hyperalgesia;Hypersensitivity;imaging approach;In Situ;Inflammation;Inflammatory;inflammatory pain;inhibitor;Injury;innovation;Ion Channel;Ions;Laboratories;Lateral;Lead;Long-Term Potentiation;Maintenance;mechanical allodynia;Mechanical Stimulation;Medical;Membrane;migration;Molecular;Molecular and Cellular Biology;Motivation;mouse model;N-ethylmaleimide-sensitive protein;Names;nerve injury;Neurons;Nociception;Non-Steroidal Anti-Inflammatory Agents;novel therapeutics;Opioid;optogenetics;Pain;pain behavior;pain chronification;Pain management;pain model;pain perception;pain processing;pain sensation;painful neuropathy;Pathway interactions;Peripheral;Peripheral Nervous System;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Play;Population;Postsynaptic Membrane;Prosencephalon;Protein Isoforms;protein protein interaction;receptor;Recycling;Regulation;Research;response;Role;Sensory;side effect;spared nerve;Stimulus;Structure;superresolution imaging;Surface;Synapses;Synaptic plasticity;Technical Expertise;Techniques;Testing;trafficking

PROJECT_TITLE: Molecular Mechanism of Brain Regulation of Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-W(50)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE One of the earliest events in development is the replacement of maternal biomolecules like RNA with new ones made by the embryo. A major question is how the embryo distinguishes old, maternal RNAs from the new, embryonic RNAs. Here, we will explore a new conceptual framework whereby the experiences of maternal RNAs during oogenesis prime the biomolecules for removal during early embryogenesis, thus ensuring proper development of the embryo.

PI_NAMEs: RISSLAND, OLIVIA SELFRIDGE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Alleles;Animals;Biological Models;Communities;computational pipelines;computerized tools;Data Set;Deposition;Detection;Development;Dosage Compensation (Genetics);Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;Ensure;Event;Excision;experience;experimental study;Exploratory/Developmental Grant;Female;Future;Genes;Genome;Goals;Grant;Hand;Length;Maintenance;male;Maternal Messenger RNA;Messenger RNA;Modeling;Modification;Molecular;mRNA Decay;novel strategies;Oogenesis;Play;Poly(A) Tail;posttranscriptional;Process;Production;Protein Isoforms;Regulation;Repression;Research;RNA;RNA-Binding Proteins;Role;sex;Sex Chromosomes;sex determination;Specific qualifier value;Tail;Testing;Transcript;transcriptome;Translations

PROJECT_TITLE: Developmental priming of mRNA decay during Drosophila embryogenesis

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Inherited degenerative diseases of the retina, which affect over two million individuals worldwide, represent a genetically and phenotypically heterogeneous group of visual disorders characterized by progressive photoreceptor cell loss. Many forms of inherited retinal degeneration are associated with defects in the formation of the light-sensitive outer signet compartment of rod and cone photoreceptor cells. Studies described in this application aim to elucidate the most fundamental molecular mechanisms responsible for the outer segment morphogenesis, thereby providing scientific basis for developing effective strategies for disease treatment and prevention.

PI_NAMEs: ARSHAVSKY, VADIM Y (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Mechanisms of photoreceptor disc maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(02)M]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Digestive Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Intestinal dysmotility disorders and obstructions are under-researched and associated with enormous management costs and life-long adverse outcomes. To expand our understanding of these disorders, we investigate how mechanosensors in the gut control bowel motility, allowing each bowel segment to sense and respond to stretch. We believe that this project may have essential findings in studying this group of patients and may also have therapeutic implications.

PI_NAMEs: DUNN, JAMES C;MARTIN, MARTIN G (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acute;adverse outcome;Applications Grants;bioelectricity;Biological Models;Biomechanics;Biomedical Engineering;Calcium;Calcium Channel;cell type;Cells;Cellular Structures;Clinical;comparison control;cost;Cues;Data;Disease;effective therapy;Enteral;Enterochromaffin Cells;Enteroendocrine Cell;Epithelium;Event;experimental study;Failure;Frequencies;Gap Junctions;Genetic;genetic approach;Giant Cells;Goals;Growth;Hydrogels;Impairment;In Vitro;in vitro Model;in vivo;innovation;insight;Interstitial Cell of Cajal;intestinal epithelium;Intestinal Obstruction;Intestines;Ion Channel;Knock-out;mechanical force;Mechanics;mechanotransduction;Mediating;Methods;Modeling;Molecular;Morphology;Motility;motility disorder;Mus;Myopathy;Neuroglia;Neurons;nodal myocyte;novel;Obstruction;Patients;Phase;Physiological;Piezo 1 ion channel;Pilot Projects;Platelet-Derived Growth Factor Receptor;Process;Property;Receptor Cell;release of sequestered calcium ion into cytoplasm;Research;response;Role;scaffold;sensor;Small Intestines;Smooth Muscle Myocytes;stem;Stretching;System;Testing;Therapeutic;Thick;tool;Tracer;transmission process;Villus

PROJECT_TITLE: Piezo-1 & 2’s role in murine intestinal muscularis cells of the SIP syncytium

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WINSTON-SALEM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Each year 7 million patients seek care in U.S. Emergency Departments for chest pain. Most moderate-risk patients undergo hospitalization for expensive testing aimed at identifying a heart attack, which costs the healthcare system more than $3 billion annually without a clear improvement in patient outcomes. Our study will compare rapid outpatient vs hospitalization management to determine the best strategy (based on patient- centered measures and safe, equitable, and efficient resource use) for evaluating these patients.

PI_NAMEs: MAHLER, SIMON A (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients with Chest Pain (CARE-CP)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: The number of older Veterans with Mild Cognitive Impairment (MCI) seeking care within the Veterans Affairs (VA) health care system is increasing and is expected to increase more rapidly as Vietnam era Veterans age. The cognitive effects of MCI and subsequent neurodegenerative disorders can adversely affect a Veteran’s ability to function independently and failure to provide appropriate intervention can result in an increased need for healthcare services and VA benefits in the future. The VA currently spends over $19,000 annually per patient to care for Veterans with dementia (Zhu et al., 2009), and delaying the onset of dementia even by one to two years will result in substantial financial savings to the VA and quality of life gains for the Veteran. Since present pharmacological interventions have demonstrated limited efficacy, alternative treatments are needed. Therefore, an evidence-based cognitive training intervention that optimally addresses the needs of older Veterans with MCI is of critical importance to the VA patient care mission.

PI_NAMEs: O'NEIL, MAYA ELIN;TWAMLEY, ELIZABETH W (contact)

PROJECT_TERMS: Abstinence;acceptability and feasibility;active control group;Activities of Daily Living;Address;Adoption;Adult;Affect;Age;age related;Aging;alternative treatment;Alzheimer's Disease;Attention;Auditory;Behavior Therapy;California;care seeking;Caring;Clinical Trials;Cognition;Cognitive;cognitive performance;cognitive rehabilitation;cognitive training;Control Groups;Craniocerebral Trauma;Dementia;demographics;Diagnosis;Diet;Educational Intervention;effective therapy;efficacy evaluation;eligible participant;Enrollment;Equipment and supply inventories;Evaluation;evidence base;Evidence based treatment;Exclusion Criteria;executive function;Exercise;Exhibits;Failure;follow-up;Frequencies;Future;Goals;Health;health administration;health care service;Healthcare;Healthcare Systems;Hour;Impaired cognition;Impairment;improved;inclusion criteria;Independent Living;Individual;Informed Consent;Intervention;Life Style;Manuals;Measures;Mediating;Mediation;Mediator;medication compliance;Memory;mild cognitive impairment;mild traumatic brain injury;Mission;Motivation;motivational enhancement therapy;multimodality;Neurodegenerative Disorders;older adult;Oregon;Participant;Patient Care;patient oriented;Patients;peer;Performance;person centered;Pharmaceutical Preparations;pharmacologic;Physical Exercise;Pilot Projects;Population;Post-Traumatic Stress Disorders;prevent;primary endpoint;primary outcome;protective factors;Psyche structure;Psychotic Disorders;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Design;Resources;Risk;Risk Factors;Sampling;Savings;scale up;Schizoaffective Disorders;Schizophrenia;secondary endpoint;secondary outcome;Services;Site;substance use;Substance Use Disorder;symptom treatment;tool;Training;treatment effect;treatment group;Unconscious State;United States;Veterans;Veterans Health Administration;Vietnam;Visual impairment;willingness;Work

PROJECT_TITLE: Cognitive Rehabilitation for Older Veterans with Mild Cognitive Impairment

STUDY_SECTION: NURD

STUDY_SECTION_NAME: Neurobiology D[NURD]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This research will advance fundamental knowledge in the diagnosis of concussion and generate practical insights for equitably operationalizing baseline testing to improve health outcomes for those at risk of concussion. Through multi-disciplinary collaboration and wide dissemination of our findings, this research can transform how clinicians and athletic trainers approach concussion diagnosis for those who may be under- represented in the development of existing clinical guidelines, leading to more timely and accurate diagnosis of concussion.

PI_NAMEs: GARCIA, GIAN-GABRIEL  (contact)

PROJECT_TITLE: Design, Analysis, and Optimization of Equitable and Value-based Baseline Testing Policies for Sports-Related Concussion


NIH_SPENDING_CATS: Dissemination and Implementation Research;HIV/AIDS

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: This project, "Ukraine HIV Research Training Program” will build capacity to address the gaps in HIV treatment and prevention that have emerged following the initiation of the conflict with Russia. This will be carried out in partnership with the School of Public Health at National University of Kyiv-Mohyla Academy, linked with a research NGO, Ukrainian Institute for Public Health Policy. The public health relevance is that these research capacity building efforts will be designed to minimize HIV-related morbidity and mortality in the midst of a humanitarian crisis.

PI_NAMEs: DEHOVITZ, JACK A (contact);KIRIAZOVA, TETIANA

PROJECT_TERMS: Academy;Acquired Immunodeficiency Syndrome;addiction;Award;career;Conflict (Psychology);cost effective;Country;design;Development;Educational Curriculum;Educational workshop;Epidemic;Epidemiology;Fellowship;Goals;Health Policy;HIV;implementation science;Individual;Institution;International;Internships;Invaded;Investments;Link;Measures;Mentorship;Modality;New York;Nongovernmental Organizations;Participant;Persons;population based;programs;Public Health;Public Health Education;Public Health Schools;Qualitative Research;Research;Research Personnel;Research Training;response;Role;Students;symposium;Time;Training;Training Programs;Ukraine;War;Writing

PROJECT_TITLE: Ukraine HIV Research Training Program


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Lung cancer is a major public health problem in the United States (US), with more lives lost due to lung cancer than to breast, prostate, and colorectal cancers combined. Despite the US Preventive Services Task Force recommendation for annual lung screening among high risk current and former smokers, it is underutilized (3- 14% uptake) across all racial/ethnic groups. As this disease disproportionately affects African Americans due to late-stage diagnosis and poorer lung cancer survival than whites, there is an urgent public health need to address systemic barriers contributing to disparities in lung cancer between African Americans and whites. Interventions that address multiple barriers are needed to reduce disparities in the uptake of cancer screening. I will use my K99 training to inform the development of a provider- and patient-level intervention that will be tested in the R00 phase to improve lung screening awareness, screening completion overall, and to achieve equity in screening rates.

PI_NAMEs: WILLIAMS, RANDI M. (contact)

PROGRAM_OFFICER_NAME: RANDHAWA, GURVANEET

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;advanced disease;Affect;African American;African American population;Award;Awareness;Behavior;Cancer Control;Cancer Etiology;cancer health disparity;cancer survival;care preference;career;Cessation of life;Clinic;Clinical;Collaborations;Colorectal Cancer;Comprehensive Cancer Center;Computerized Medical Record;Control Groups;Data;design;Development;Diagnosis;Disease;Disparity;disparity reduction;Early Diagnosis;electronic medical record system;Electronics;Eligibility Determination;Enrollment;Environment;Equity;ethnic minority;Ethnic Population;Feasibility Studies;former smoker;Future;Health;health care disparity;health care settings;Health Disparities Research;health disparity;health literacy;Health Personnel;Health Services Accessibility;Healthcare Systems;high risk;high risk population;improved;Individual;Institution;Insurance Coverage;Intention;Intervention;intervention participants;Interview;Knowledge;Length;low dose computed tomography;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Measures;Mentors;Minority;Minority Groups;Morbidity - disease rate;mortality;Notification;Outcome;outreach;Participant;Patient Education;patient level intervention;Patient Preferences;patient-clinician communication;Patients;Persons;Phase;Physicians;Pre-Post Tests;preference;Primary Care;primary care clinic;primary care provider;primary outcome;Printing;Provider;Public Health;Quasi-experiment;Race;racial minority;racial population;Recommendation;Recording of previous events;Reporting;Research;Research Methodology;Resources;Schedule;Scientist;screening;screening disparities;Screening for cancer;secondary outcome;Smoker;Smoking History;Specialist;Surveys;System;systemic barrier;Telephone;Testing;Thoracic Radiography;tool;Training;United States;United States National Institutes of Health;United States Preventative Services Task Force;uptake;Visit

PROJECT_TITLE: A Multilevel intervention to address health disparities in lung cancer screening


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will improve our understanding of the establishment of population-coding neural networks, which are fundamental functional units in the nervous system, and provide the knowledge needed for understanding the basis of neurological and mental disorders. Thus, the proposed research is relevant to NIH’s mission because it is expected to develop fundamental knowledge that will help to reduce the burdens of nervous system disorders.

PI_NAMEs: YE, BING  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Abdomen;Animals;Anterior;Brain;Candidate Disease Gene;Cells;Code;Cues;Development;Drosophila genus;Ensure;Exhibits;experimental study;Genes;Genetic;Heterogeneity;Homeobox Genes;Image;improved;Individual;innovation;insight;interdisciplinary approach;Invertebrates;Knowledge;Larva;Location;Mental disorders;Mission;Modeling;Molecular;Motor;Nervous System;Nervous System Disorder;neural network;neuronal cell body;neuronal excitability;Neurons;Nociception;Nociceptors;novel;novel strategies;overexpression;patch clamp;Pathway interactions;Pattern;Perception;Physiological;Population;postmitotic;Property;Proteins;Public Health;recruit;Reporting;Research;response;Role;sensory stimulus;Specific qualifier value;Stimulus;study population;Synapses;System;Techniques;Testing;tool;transcriptomics;United States National Institutes of Health;vector;Vertebrates;Visual

PROJECT_TITLE: The assembly of population coding networks

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative HIV-1-infected cells persist lifelong despite highly efficient antiretroviral therapy, however, the surface expression profile of these cells is unknown. Here, we will use a novel single-cell next-generation sequencing approach to analyze the surface phenotype of viral reservoir cells harboring intact HIV-1 proviruses, and to evaluate longitudinal phenotypic changes of such reservoir cells during long-term ART.

PI_NAMEs: LICHTERFELD, MATHIAS  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: adaptive immune response;Address;Aftercare;antiretroviral therapy;Autologous;Binding;Biological Assay;Biological Products;Biology;biomarker identification;Blood;Blood Cells;CD4 Positive T Lymphocytes;Cells;Chromatin;chromosomal location;Clinical;Collecting Cell;design;Detection;DNA;Effector Cell;Environment;Evaluation;Evolution;Exposure to;Genetic Transcription;Genome;Heterochromatin;HIV;HIV resistance;HIV-1;Human;Immune;Immune response;Immunity;Individual;Infection;Innate Immune Response;innovation;insight;integration site;Intervention;Lead;Location;Lymphocyte;Lymphoid Tissue;Maps;Mediating;Molecular;molecular marker;novel;novel strategies;Patients;peripheral blood;permissiveness;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Predisposition;Process;Property;proteogenomics;Provirus Integration;Proviruses;Repression;Resistance;single cell sequencing;single molecule;Surface;targeted agent;Technology;Testing;Time;Tissues;Viral;Viral reservoir;viral resistance;Work

PROJECT_TITLE: Single-cell Proteogenomic profiling of HIV-1 reservoir cells


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: The University at Buffalo (UB)/State University of New York (SUNY), Upstate Medical University (Upstate/SUNY) and The University of the West Indies (UWI) Mona Campus (Kingston, Jamaica), in collaboration with the Jamaica Ministry of Health, are applying to renew the current Global Infectious Diseases (GID) Research Training Program with a continued focus on virology research training and capacity building. The research training is focused on the priority areas for public health in Jamaica and will create a workforce with skills to seek peer-reviewed funding and build an independent research program.

PI_NAMEs: LINDO, JOHN FITZGERALD;MORSE, GENE D. (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;antiviral drug development;Arboviruses;Area;Bioinformatics;Biology;Budgets;Chronic;Collaborations;Communicable Diseases;COVID-19;COVID-19 impact;Degree requirements;Development Plans;Educational Curriculum;Epidemiology;Ethics;experience;faculty mentor;Flow Cytometry;Goals;Health;Immunology;Infectious Diseases Research;innovation;Institutional Review Boards;interest;Jamaica;Laboratories;Laboratory Research;Life;Manuscripts;Mass Spectrum Analysis;Medical;Mentors;molecular diagnostics;New York;Outcome Measure;Pharmacology;Postdoctoral Fellow;pre-doctoral;Primates;programs;Protocols documentation;Public Health;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Research Training;responsible research conduct;Scientist;skills;success;Training;Training Programs;Universities;vector;Viral;Viral hepatitis;virology;Virus Diseases;West Indies;Woman;Writing

PROJECT_TITLE: Global Infectious Diseases Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: The overall goal of this project is to develop first in class radiotracers to study in vivo how immune cells mobilize granzymes to combat deadly pathogens. This project will span new probe development and application to clinically relevant animal models of viral or bacterial infections and conclude with late stage preclinical studies to establish the long term feasibility of human imaging for this novel probe class. If successful, this project will confer new translational tools to begin probing the emerging non-cytotoxic functions in host defense for this enigmatic enzyme class.

PI_NAMEs: CRAIK, CHARLES SCOTT;EVANS, MICHAEL JOHN (contact);WILSON, DAVID M

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Amino Acids;analog;Animal Model;anti-cancer;Apoptotic;Bacteria;Bacterial Infections;Biochemistry;Biodistribution;Biological Assay;Biological Models;Biology;Bypass;cancer cell;Cell Death;Cell membrane;Cells;clinical application;clinically relevant;clinically significant;Coculture Techniques;combat;Communicable Diseases;Complex;Cytokine Activation;Cytosol;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;Development;Disease;dosimetry;Drug Kinetics;empowerment;Endotoxins;enzyme activity;Enzymes;Escherichia coli;experimental study;extracellular;Extracellular Space;Fluorescence Resonance Energy Transfer;Germ Lines;Goals;Granzyme;Host Defense;Human;Human Activities;human imaging;Image;imaging approach;imaging probe;imaging study;Immune;Immune response;Immune system;immunological synapse;Immunology;In Vitro;in vivo;in vivo imaging;Inflammation;Inflammatory Response;Intercept;interest;Klebsiella pneumoniae;Knockout Mice;lead candidate;Listeria monocytogenes;Lymphocyte;Macrophage Activation;Masks;Mass Spectrum Analysis;Measurement;Measures;Membrane;Methodology;Modeling;Mouse Strains;Mus;Mycobacterium marinum;Mycobacterium tuberculosis;Myositis;Nature;Nerve Degeneration;novel;nuclear imaging;optical imaging;Organism;pathogen;pathogenic virus;Pathogenicity;Peptide Hydrolases;Peptides;perforin;Pharmaceutical Chemistry;pharmacologic;Phospholipids;Positron-Emission Tomography;pre-clinical;preclinical study;Productivity;Proteolysis;Pseudomonas aeruginosa;Qualifying;Radioactive;radiochemical;Radiolabeled;radiotracer;Research;Resolution;response;Rodent;Role;Safety;Serine Protease;Signal Transduction;Specificity;Staphylococcus aureus;systemic autoimmune disease;Technology;Testing;Time;tomography;tool;trafficking;Tryptase;Viral Pneumonia;Virus Diseases;Xenobiotics

PROJECT_TITLE: New radiotracer development to study immune cell mobilization of granzyme proteolytic activity


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Long-range chromatin interactions are fundamental to gene regulation. This project seeks to address some of the most critical statistical and computational deficits in studying long-range chromatin interactions. It develops novel statistical methods that can reduce noise and amplify true biological signal in noisy high throughput chromatin conformation data of single cells and innovates integrative models that can leverage model-organism multi-omics data to elucidate long-range interaction-mediated impacts of noncoding association variants on genes.

PI_NAMEs: KELES, SUNDUZ  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Address;autoencoder;Bioconductor;Biodiversity;Biologic Characteristic;Biological;cell type;Cells;Chromatin;chromosome conformation capture;Clinical;Communities;Computer Analysis;Computer software;Data;Data Analytics;data integration;data modalities;data modeling;Data Set;Dedications;denoising;Development;Dimensions;Disease;Environmental Risk Factor;epigenome;epigenomics;experimental study;flexibility;follow-up;Gene Expression Regulation;generative models;Genes;Genetic;Genome;genome wide association study;Genomic Segment;Genomics;Heterogeneity;Hi-C;high dimensionality;high throughput technology;Human;Human Genome;improved;Individual;innovation;interest;Intervention;Laboratory Organism;Link;Mammalian Cell;Maps;Measurement;Mediating;Methodology;Methods;model organism;Modeling;Molecular;Molecular Conformation;Multiomic Data;multiple omics;Mus;Nature;Noise;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;open source;Phenotype;Predisposition;programs;Property;Quantitative Trait Loci;Research;Resolution;Resources;Risk;risk variant;Role;scale up;Signal Transduction;simulation;single cell sequencing;Source;Statistical Methods;Technology;Training;trait;transcriptomics;translational genetics;Translations;Untranslated RNA;Validation;Variant

PROJECT_TITLE: High dimensional statistical data modeling and integration for studying regulatory variation

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE By screening cellular mutations induced by VSV infection which allow for escape from viral replication, we identified a cellular protein, CSDE1, as a major co-factor of VSV replication. Here, we will define how CSDE1 mediates replication of VSV, how compensatory mutations in the virus are induced to recover viral fitness in virus-resistant cells, and how we can exploit our discovery of CSDE1 as a critical co-factor for VSV replication to generate CSDE1-expressing VSV with enhanced efficacy as both vaccination and oncolytic platforms. Our studies will have significant impact in understanding VSV/host cell interactions, in defining pathways by which viruses can usurp anti-viral mutagenic pathways to seed escape-competent quasi species and will inform development of novel, improved VSV for vaccination and oncolysis.

PI_NAMEs: VILE, RICHARD G. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Affect;Antigens;Binding Sites;Cell Communication;Cells;Clonality;Code;cofactor;Complement;Consensus;Cytolysis;Data;Development;Dominant-Negative Mutation;Evolution;Exposure to;fitness;Genes;Goals;Histologic;Human;Human papillomavirus 16 E1 protein;Immune;immunogenic;imprint;improved;In Vitro;in vivo;in vivo Model;Induced Mutation;Intercistronic Region;loss of function;Mediating;Mediator;Mus;mutant;Mutate;Mutation;neoplastic cell;novel;oncolysis;Oncolytic;oncolytic Vesicular Stomatitis Virus;oncolytic virotherapy;Pathway interactions;Phenotype;Play;Point Mutation;pressure;prevent;Proteins;Resistance;Role;screening;Shock;Testing;Time;transcriptome sequencing;Treatment Failure;tumor;Tumor Antigens;TYRP1 gene;Vaccination;Vaccines;Vesicular stomatitis Indiana virus;Viral;viral fitness;Viral Genome;Virus;Virus Diseases;virus identification;Virus Replication

PROJECT_TITLE: Characterizing the role of CSDE1 as a critical co-factor for VSV replication.

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Kidney Disease;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative / Public Health Relevance Recent studies indicate that individuals with sickle cell disease (SCD) are susceptible to the development of somatic clonal hematopoiesis (CH) mutations, which may predispose to multi- organ failure in early adulthood. We will analyze a multi-center SCD cohort to determine the prevalence of CH mutations and their association with the development of heart, lung or kidney disease, which increase the probability of premature death. By defining the genetic profiles that impact the severity of SCD, we aim to design individualized therapies to safely and prospectively inhibit the development of life-threatening organ damage.

PI_NAMEs: BICK, ALEXANDER  (contact);DEBAUN, MICHAEL R.;SARAF, SANTOSH ;WEISS, MITCHELL J

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;Adult;adverse outcome;Affect;Age;Allogenic;alpha-Thalassemia;American;APOL1 gene;Autologous;Benefits and Risks;Biological Assay;Blood;Blood Cells;Blood Pressure;Blood Vessels;Cell division;Cessation of life;Child;Childhood;Chronic;Clinical;Clonal Hematopoietic Stem Cell;cohort;comorbidity;Complex;cost effective;Country;curative treatments;Data;design;Development;Disease;Disease Outcome;Disease susceptibility;DNA;DNMT3a;driver mutation;Early Intervention;emerging adult;endothelial dysfunction;exome sequencing;Functional disorder;Future;gene therapy;General Population;Genes;Genetic;Genetic study;genetic variant;Genetic Variation;genome sequencing;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Growth;Heart;heart damage;Heart Diseases;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell aging;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;Hemolysis;high risk;Incidence;Income;Individual;individualized medicine;Inflammation;Inherited;innovation;insight;JAK2 gene;Kidney;Kidney Diseases;Life;life span;Link;Lung;Lung Diseases;lung injury;Measurement;Morbidity - disease rate;mortality;multiorgan damage;Multiple Organ Failure;Mutation;Myeloid Leukemia;Myeloproliferative disease;National Heart, Lung, and Blood Institute;novel;Organ;Outcome;Pain;Patient Selection;Patients;personalized strategies;Phenotype;Predisposition;premalignant;premature;Premature Mortality;Prevalence;Prevalence Study;Probability;programs;prospective;public health relevance;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Hypertension;renal damage;Renal function;Risk;Risk Factors;Sampling;Severities;sex;Sickle Cell Anemia;Somatic Mutation;Statistical Models;stem cell gene therapy;Symptoms;System;Technology;Testing;Therapeutic;TP53 gene;Trans-Omics for Precision Medicine;transplantation therapy;treatment risk;United States National Institutes of Health;Variant;whole genome;Work;young adult

PROJECT_TITLE: Clonal hematopoiesis and inherited genetic variation in sickle cell disease

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

PHR: PROJECT NARRATIVE Human pluripotent stem cells offer the potential to revolutionize treatment of heart disease. The label-free analytic technologies developed in this proposal could enhance robust production of safe and potent stem cell derived cardiomyocytes for drug development, disease modeling, toxicity testing, and regenerative therapy.

PI_NAMEs: PALECEK, SEAN P;SKALA, MELISSA CAROLINE (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;Allogenic;Arrhythmia;Autologous;Benchmarking;Biological Assay;Biomanufacturing;Bioreactors;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;Cell Count;Cell Line;Cell Maturation;Cell Physiology;Cell Therapy;Cells;cellular imaging;Cellular Metabolic Process;Cellular Morphology;Classification;Clinical;Clinical Trials;Coenzymes;Computer Models;cost;Data;Data Set;Development;disease model;drug development;Early identification;Electrophysiology (science);Embryo;Failure;Fatty Acids;Flow Cytometry;Fluorescence;Generations;Glucose;Glycolysis;Goals;Healthcare;Heart Diseases;Heart failure;Heterogeneity;Human;human induced pluripotent stem cells;human pluripotent stem cell;improved;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Label;manufacture;Marketing;Measurement;Metabolic;metabolic imaging;Metabolism;Methods;Microscopy;Modeling;Monitor;monolayer;Mus;Neonatal;new technology;Optics;oxidation;Pharmaceutical Preparations;Phenotype;Photons;predictive modeling;Procedures;Process;Production;Protocols documentation;Quality Control;regenerative therapy;Research;Resolution;scale up;sex;spheroids;stem cells;Structure;System;Technology;Testing;Time;Tissues;tool;Touch sensation;Toxicity Tests;Toxicology;two photon microscopy;two-photon;Withdrawal

PROJECT_TITLE: Label-free single-cell imaging for quality control of cardiomyocyte biomanufacturing


ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Dystonia, the third most common motor disease, is debilitating at all ages, but its onset in children is a growing crisis because the causative mechanisms create unique long-term health concerns. Although recent efforts have discovered brain areas involved in dystonia, the current study addresses a major gap in knowledge by identifying a genetic cue that instructs the formation of a core dystonia circuit. This proposal tests how dystonia-causing circuits develop in order to pinpoint new therapeutic targets.

PI_NAMEs: SILLITOE, ROY VINCENT (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Adult;Affect;Age;Animal Model;Animals;Antipsychotic Agents;Area;Basal Ganglia;Behavior;Behavioral Paradigm;Birth;Blepharospasm;Brain;Brain region;Brain Stem;Calcium Channel;cell type;Cells;Cerebellar Cortex;Cerebellum;Characteristics;Child;cholinergic;comorbidity;conditional mutant;Cues;Data;Deep Brain Stimulation;Defect;Dependence;design;Development;Disease;Dystonia;Dystonia Musculorum Deformans;Early Onset Dystonia;Electrophysiology (science);Embryo;Eyelid structure;Face;Functional disorder;gene function;Genes;Genetic;genetic manipulation;Genetically Engineered Mouse;Glutamates;granule cell;Health;Healthcare;hindbrain;Homeobox;Homologous Gene;improved;in vivo;Inherited;Injections;insight;Kainic Acid;knock-down;Knockout Mice;Knowledge;Life;Limb structure;Mediating;Midbrain structure;Modeling;Molecular;Molecular Genetics;Molecular Probes;Morphogenesis;Morphology;Motor;motor behavior;motor disorder;mouse model;Mus;Muscle;Muscle Contraction;mutant;Mutant Strains Mice;Mutation;Names;Nature;Nervous System Disorder;neural;Neurons;neuropsychiatric disorder;Neurotransmitters;new therapeutic target;Onset of illness;optogenetics;Ouabain;Output;P-Q type voltage-dependent calcium channel;Pain;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;pediatric patients;Persons;Pharmaceutical Preparations;Phenotype;postnatal;Posture;Predisposition;pup;Purkinje Cells;Quality of life;Rattus;Regulation;repaired;Role;Severities;small hairpin RNA;Structure;success;Symptoms;Testing;Thalamic structure;Therapeutic;therapeutic target;Tremor;virtual;Writer's cramp neurosis

PROJECT_TITLE: Spatial and temporal pathophysiology of developmental dystonia


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Infectious Diseases;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Epilepsy is a serious neurological disorder that can develop as a consequence of viral infection and traumatic injury to the brain. NG2-glia are a major glial cell-type that regulate inflammation, scar formation, and neuroplasticity changes following injury, yet their role in the development of epilepsy remains unknown. It is envisioned that these studies will lead to new hypotheses and treatment strategies regarding the development of epilepsy following viral infections and brain injury in humans.

PI_NAMEs: BELL, LAURA ANN (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Active Sites;Acute;Affect;Antiepileptogenic;Brain;Brain Injuries;Calcium;Calcium Signaling;career;cell type;Cells;cellular targeting;Central Nervous System;Central Nervous System Infections;central nervous system injury;Central Nervous System Viral Diseases;Chronic;Cicatrix;Classification;Confocal Microscopy;CSPG4 gene;Development;Disease;Epilepsy;Epileptogenesis;Etiology;Event;experimental study;extracellular;Foundations;Future;Generations;genetic approach;Genetic Transcription;Goals;high risk;Hippocampus;Homeostasis;Human;Image;Immunohistochemistry;improved;in vivo;Infection;Inflammation;Injury;intercellular communication;Intervention;Lesion;Life;Link;Maintenance;Maps;Maus Elberfeld virus;Methods;Modeling;Molecular;Molecular Target;Morphology;mouse model;multiphoton imaging;Nervous System Disorder;neural network;Neuroglia;Neurologic;Neuronal Plasticity;Neurons;novel;oligodendrocyte progenitor;Patients;Persons;pharmacologic;Phase;Physiology;Play;Postdoctoral Fellow;prevent;Process;Proliferating;promoter;protein expression;Purines;Purinoceptor;Reaction;Recovery;Recovery of Function;Refractory;Reporter;Research;Research Project Grants;Resources;response;Role;Seizures;Severities;Signal Transduction;Site;Slice;stem cells;Structure;Therapeutic;therapeutic target;Time;TMEV;transcriptomics;Transgenic Mice;Traumatic Brain Injury;Traumatic injury;treatment strategy;two-photon;Viral;Virus Diseases;visual map;Work

PROJECT_TITLE: Investigating the role of NG2-glia in the development of epilepsy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Behavior of HIV In Viral Environments (B-HIVE) Center is focused on understanding how HIV-1 molecular components, both proteins and nucleic acids, behave in various cellular environments at different times during the HIV-1 replication cycle. The findings will be important for efforts to eradicate HIV/AIDS.

PI_NAMEs: SARAFIANOS, STEFAN G;TORBETT, BRUCE EDWARD (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Behavior;Binding Sites;Biological;Biophysics;Capsid;Cell Communication;Cell Nucleus;Cells;Characteristics;Chemicals;Collaborations;Communication;Computational Biology;Cytoplasm;Disease;Environment;Evolution;experience;Funding;gene product;Genetic Transcription;Genome;Goals;HIV;HIV Integrase;HIV-1;HIV/AIDS;Human Resources;Infection;Infrastructure;inhibitor;insight;Integration Host Factors;integration site;Joints;Leadership;Life Cycle Stages;member;Mentors;Modeling;Molecular;next generation;novel;novel therapeutic intervention;Nuclear;Nuclear Accidents;Nucleic Acids;Nucleosome Core Particle;organizational structure;outreach;particle;Pathogenesis;Positioning Attribute;Production;programs;protein complex;Proteins;Publications;Research;Research Personnel;RNA;RNA-Directed DNA Polymerase;Role;Scientific Advances and Accomplishments;Shapes;Site;small molecule;small molecule inhibitor;success;Synthesis Chemistry;Testing;trafficking;Training;United States National Institutes of Health;Universities;Viral;Viral Packaging;viral RNA;virology;Virus;Virus Replication;Washington

PROJECT_TITLE: Behavior of HIV in Viral Environments (B-HIVE)


NIH_SPENDING_CATS: HIV/AIDS

PI_NAMEs: TORBETT, BRUCE EDWARD (contact)

PROJECT_TERMS: Behavior;candidate selection;Collaborations;Communication;Communities;Development;Ensure;Environment;equity, diversity, and inclusion;Event;Faculty;Fostering;Funding;Funding Opportunities;Goals;graduate student;HIV;Home;Individual;Institution;Leadership;Location;meetings;member;Mission;Monitor;Names;National Institute of Allergy and Infectious Disease;next generation;operation;outreach program;programs;recruit;Reporting;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Strategic Planning;student training;Sum;Technology;Thinking;Time;Training;United States National Institutes of Health;videoconference;Viral;virology;Vision;web site

PROJECT_TITLE: Admin Core


PI_NAMEs: KIRBY, KAREN A (contact)

PROJECT_TERMS: Behavior;Behavior assessment;Biology;Collaborations;collaborative environment;Communication;Communities;community center;Community Outreach;design;Development;Education and Outreach;Educational Materials;Environment;Fellowship Program;General Population;Generations;Goals;high school;HIV;innovation;Institution;Internships;Intranet;member;Methodology;multimodality;Organization and Administration;outreach;Policies;Postdoctoral Fellow;Procedures;Program Development;programs;recruit;Research;Research Personnel;Scientist;Students;Training;Training Activity;Training Programs;undergraduate student;Viral;web site

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Networking and Information Technology R&D (NITRD)

PI_NAMEs: VOTH, GREGORY A. (contact)

PROJECT_TERMS: Acceleration;Affinity;Area;Back;Behavior;Binding;Biological;Biological Models;Biotinylation;Capsid;chemical function;Chemicals;Chemistry;Collaborations;Communities;Complement;Computer software;computer studies;computerized tools;Computing Methodologies;Data;design;Development;Docking;Ensure;Environment;Event;fitness;Foundations;Free Energy;Goals;Grain;HIV;HIV-1;information gathering;inhibitor;innovation;Integration Host Factors;interest;kinetic model;Kinetics;Label;Length;Life Cycle Stages;Machine Learning;Mediating;Membrane;Methodology;Methods;model building;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Molecular Probes;multi-scale modeling;Mutation;nano;Nature;Nucleic Acids;Postdoctoral Fellow;Process;protein protein interaction;Proteins;Protocols documentation;rational design;Research;Research Personnel;Resources;Role;Sampling;Science;simulation;Site;small molecule;Solvents;spatiotemporal;Speed;Structural Models;Structure;Students;Synthesis Chemistry;Therapeutic;Thermodynamics;Time;tool;training opportunity;Viral;virtual;virtual screening;Work

PROJECT_TITLE: Computation & Chemistry Core


ORG_CITY: DETROIT

ORG_DEPT: GENETICS

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative Hypertriglyceridemia is a major metabolic disorder that frequently precedes or co-exists with metabolic and cardiovascular diseases. This project will identify a stress-induced secreted protein factor, named CREBH-C, which can boost triglyceride metabolism and thus mitigate hypertriglyceridemia and the associated metabolic disorders. Delineating the molecular mechanism and functional significance of this novel protein factor will have a major impact in the prevention and treatment of human metabolic and cardiovascular diseases.

PI_NAMEs: ZHANG, KEZHONG  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: ANGPTL3 gene;Animal Genetics;Animal Model;Atherosclerosis;Binding Proteins;Blood;Blood capillaries;C-terminal;calmodulin-dependent protein kinase II;Cardiovascular Diseases;Cells;circadian regulation;Circulation;Complex;Cyclic AMP-Responsive DNA-Binding Protein;Diet;Endoplasmic Reticulum;Endothelial Cells;Energy Metabolism;Exocytosis;Extracellular Space;Fasting;Fatty acid glycerol esters;flexibility;Funding;Genetic Transcription;Golgi Apparatus;Hepatic;Homeostasis;Human;Hypertriglyceridemia;innovation;Intervention;Knockout Mice;Lipids;Lipolysis;lipoprotein lipase;Liver;Mediating;Membrane;Membrane Proteins;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;Molecular;Monitor;Mus;Names;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ;Overnutrition;Pathway interactions;Peripheral;Phosphorylation;Phosphotransferases;Physiological;Plasma;prevent;Prevention;Process;Protein Fragment;Protein Secretion;Proteins;Proteolysis;reconstitution;Regulation;Regulatory Pathway;response;Risk Factors;Role;sensor;Stress;Stress-Induced Protein;Tertiary Protein Structure;Testing;Therapeutic Intervention;therapy design;Tissues;transcription factor;Triglyceride Metabolism;Triglycerides;uptake

PROJECT_TITLE: A novel CREBH-derived hepatokine regulates triglyceride metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


PI_NAMEs: LYUMKIS, DMITRY  (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Affect;Amino Acids;antiretroviral therapy;Architecture;Behavior;Binding;Biological;Biology;Chemicals;Collaborations;Collection;Communities;Complex;Consultations;Coupled;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Collection;Databases;design;Deuterium;Development;Educational workshop;Environment;Evaluation;Experimental Designs;Fluorine;Future;Goals;HIV;HIV-1;Hydrogen;image processing;Individual;inhibitor therapy;insight;instrumentation;interest;Laboratories;Ligands;macromolecular assembly;Macromolecular Complexes;macromolecule;Mass Spectrum Analysis;Measurement;member;Methods;Microscopy;Molecular;Molecular Conformation;Molecular Mechanisms of Action;Molecular Probes;Molecular Structure;Negative Staining;new technology;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Nucleic Acids;Operating Rooms;particle;Phase;Play;protein complex;protein function;Proteins;Regulation;Research;Research Personnel;Resolution;Resources;Role;Sampling;Services;small molecule;structural biology;Structure;synergism;tandem mass spectrometry;Techniques;Technology;technology development;Time;Titan;tool;Training;United States National Institutes of Health;Validation;videoconference;Viral;Viral Proteins;Virus;Virus Replication;voltage

PROJECT_TITLE: Structural Biology Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS

PI_NAMEs: MELIKIAN, GREGORY B (contact)

PROJECT_TERMS: Acylation;Automobile Driving;Beds;Behavior;Biological;Biological Models;biophysical analysis;biophysical properties;biophysical techniques;Biophysics;Capsid;Cells;cellular imaging;Cellular Structures;Complex;Coupled;crosslink;Detection;Development;Educational workshop;Environment;Equipment;Event;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Goals;HIV;HIV-1;Hydroxyl Radical;Image;In Vitro;insight;instrumentation;Investigation;Joints;Label;Life Cycle Stages;Machine Learning;Macromolecular Complexes;Mass Spectrum Analysis;Membrane Proteins;Mission;new technology;novel imaging technology;Nuclear Import;Nucleic Acids;Ohio;particle;Persons;Phase;Photobleaching;Primer Extension;Process;protein complex;Protein Dynamics;Proteins;quantitative imaging;Research Personnel;Resources;response;RNA;RNA Probes;Services;single molecule;Spectrum Analysis;stoichiometry;structural biology;superresolution imaging;Techniques;Technology;Testing;tool;Training;Universities;videoconference;Viral;Visit;Visualization

PROJECT_TITLE: Biophysics Core


PI_NAMEs: ROUTH, ANDREW LAURENCE (contact)

PROJECT_TERMS: antiretroviral therapy;Area;Behavior;Bioinformatics;Biological;Biology;Capsid;Cell Culture Techniques;Cells;Chromatin Structure;chromosomal location;Chromosome Structures;Clinical;Collaborations;Communities;Complementary DNA;Computer Analysis;Computer software;Core Facility;crosslink;Data;Databases;Development;DNA Sequencing Facility;Drug resistance;Environment;Event;Evolution;experience;Experimental Designs;experimental study;Exposure to;Gene Expression;Genetic Recombination;Genome;genome sequencing;Genomic approach;HIV;HIV Genome;Human Resources;In Situ;In Vitro;Individual;innovation;insight;Integrase;integration site;Length;Life Cycle Stages;Location;Measures;Messenger RNA;Minority;Molecular;Molecular Biology;molecular sequence database;Molecular Virology;Mutation;nanopore;new technology;next generation sequencing;novel;novel strategies;Nucleic Acids;Nucleotides;Nuts;Output;particle;Pattern;Pharmacotherapy;Polymerase;pressure;Process;Protein Isoforms;Proteins;Research;Research Personnel;Research Project Grants;resistance mutation;Resolution;Resources;response;RNA;RNA Splicing;RNA Viruses;RNA-Protein Interaction;Role;Sampling;sequencing platform;Services;single cell sequencing;single cell technology;single molecule;Single Nucleotide Polymorphism;Site;skills;small molecule inhibitor;Specimen;Structure;System;Techniques;Technology;technology platform;tool;Training;transcriptome sequencing;transcriptomics;Universities;Variant;Viral;Viral Genome;viral genomics;virology;Virus;Virus Replication;Work

PROJECT_TITLE: Sequencing and Bioinformatics


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: SARAFIANOS, STEFAN G (contact)

PROJECT_TERMS: activation-induced cytidine deaminase;Anti-viral Agents;Avidity;base;Behavior;Binding;Binding Proteins;Binding Sites;Biochemistry;biophysical techniques;Black Box;Capsid;Capsid Proteins;Caring;Cell Nucleus;Cells;cofactor;Complex;Computing Methodologies;Coupled;Cryoelectron Microscopy;Cytoplasm;Data;Dependence;Development;Drug Industry;Drug resistance;Drug Targeting;Ensure;Environment;experience;Foundations;frontier;Future;Glycine;Goals;HIV;HIV-1;Hydrophobicity;improved;in silico;Infection;inhibitor;innovation;insight;Knowledge;Label;Lead;live cell microscopy;Mediating;Molecular;Molecular Biology;molecular modeling;multidisciplinary;next generation;novel;novel therapeutics;Nuclear;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Outcome;Patients;Peptides;Persons;Pharmaceutical Chemistry;Phase III Clinical Trials;Phenylalanine;Phosphotransferases;Prevention;Productivity;protein protein interaction;Proteins;Proteomics;Regulatory Pathway;Research;Resistance;resistance mechanism;Resistance profile;Route;screening;Shapes;Site;small molecule;small molecule inhibitor;structural biology;structural determinants;Structure;Surface;targeted treatment;therapeutic target;Validation;Variant;Viral;Viral Drug Resistance;virology;Virus;virus core;virus host interaction;Virus-like particle;X-Ray Crystallography

PROJECT_TITLE: Dynamics of HIV Core Interactions


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE ATP-sensitive potassium (KATP) channels regulate membrane excitability according to the energetic state of a cell, and dysfunction of these channels underlie a number of devastating human diseases. The goal of this project is to understand the structural mechanisms governing the activity of various KATP channel subtypes found in different tissues in order to design better drugs to treat diseases caused by channel dysfunction.

PI_NAMEs: SHYNG, SHOW-LING  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: 3-Dimensional;Address;Anti-diabetic Drugs;Artificial Intelligence;ATP-Binding Cassette Transporters;Binding;Binding Sites;Biochemical;Biological Assay;biophysical properties;Blood Vessels;Brain;Cantu syndrome;Cardiac;Cardiovascular Diseases;Cell Energetics;Cells;Collaborations;Complex;cost;Cryoelectron Microscopy;Data;design;Development;Disease;DNA Sequence Alteration;drug action;drug discovery;drug mechanism;Drug or chemical Tissue Distribution;Endocrine System Diseases;Environment;Functional disorder;gain of function mutation;Genetic Diseases;Glyburide;Goals;Hair;Health;Heart;Homeostasis;Human;human disease;Hypertension;Hypotension;in silico;inhibitor;innovation;insight;insulin secretion;inward rectifier potassium channel;Ion Channel;ischemic injury;Kidney;Knowledge;Ligands;Literature;Membrane;Membrane Proteins;Metabolic;MgADP;Molecular Conformation;molecular dynamics;Mutagenesis;mutant;Mutation;Myopathy;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Outcome;Pancreas;particle;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphatidylinositol 4,5-Diphosphate;Physiological;Physiological Processes;Pinacidil;Play;Potassium;Property;protein complex;Protein Isoforms;Publishing;Regulation;repaglinide;Research;Research Personnel;Resolution;Role;screening;sensor;side effect;Skeletal Muscle;Smooth Muscle;Specificity;Structure;Structure-Activity Relationship;success;sulfonylurea receptor;targeted treatment;Testing;three dimensional structure;Tissues;Variant;Vascular Smooth Muscle;Vasodilation;virtual;Work

PROJECT_TITLE: Correlating structure and function in KATP channel isoforms

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Genetics;Neurosciences;Sleep Research

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE The main aim of this project is to uncover molecular and physiological mechanisms of ultradian (shorter than a day) rhythms in the brain. To do so, we will focus on the glia that displays simultaneously ultradian and circadian (24 hr) rhythms. Understanding how ultradian rhythms are generated and their physiological outputs has obvious implications for human health, especially given the role of biological rhythms in sleep disturbances, mental illness and many other diseases.

PI_NAMEs: KADENER, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Aerobic;Area;ATAC-seq;Behavioral;Binding Sites;Biological Rhythm;Brain;candidate identification;cell type;Cells;circadian;circadian pacemaker;Circadian Rhythms;Computer Analysis;Darkness;Data;Disease;Drosophila genus;environmental change;fly;Food;Future;Gene Expression;Genes;Genetic Screening;Genetic Transcription;Health;Hormone secretion;Hour;Human;Hydrocortisone;Insulin;Light;Link;Mental Depression;Mental disorders;Molecular;Network-based;Neuroglia;Neurons;non rapid eye movement;Organism;Output;Periodicity;Physiological;Physiology;Regulation;Reporter;Reporting;Research;RNA;Role;Saccharomyces cerevisiae;single cell sequencing;Sleep;Sleep Disorders;Sleep disturbances;Temperature;Testing;Time;tool;Transcript;Transcriptional Regulation;transcriptome sequencing;Work

PROJECT_TITLE: Uncovering the Origin and Mechanisms of Ultradian Rhythms in the Drosophila Brain


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: ENGELMAN, ALAN N. (contact)

PROJECT_TERMS: Address;Affect;antiretroviral therapy;Bar Codes;base;Behavior;Binding;Biochemistry;Bioinformatics;biophysical techniques;Biophysics;C-terminal;CD4 Positive T Lymphocytes;Cell Communication;Cell Line;Cell Nucleus;Cells;Cellular biology;Centromere;Chemistry;Chimeric Proteins;Chromatin;Clinical;Clinical Virology;Competence;Complex;Computer Models;Cryoelectron Microscopy;Development;DNA;DNA Integration;DNA Repair Enzymes;Environment;Free Energy;G22P1 gene;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Growth Factor;histone modification;HIV;HIV Infections;HIV-1;Human Genome;Image;Imaging Techniques;In Vitro;in vivo;Individual;Infection;insight;Integrase;Integration Host Factors;integration site;Kinetics;Knowledge;Laboratories;Laboratory Research;latent HIV reservoir;latent infection;lens epithelium-derived growth factor;Link;Location;migration;Molecular;molecular dynamics;molecular modeling;Molecular Probes;Molecular Target;mutant;novel;Nuclear;Nuclear Accidents;Nuclear Import;Nucleoplasm;Nucleosomes;particle;Penetration;Physiological;Positioning Attribute;preference;prevent;Process;Production;Protein Chemistry;Proteomics;Proviruses;repaired;Reporter;Research;Resolution;response;Reverse Transcription;RNA;Role;Site;spatial integration;Structure;Surface;System;T-Lymphocyte;tat Protein;Technology;trafficking;Trans-Activators;Transcription Initiation;translation assay;Viral;viral DNA;Virion;virology;Virus;Virus Integration

PROJECT_TITLE: Dynamics of HIV Nuclear Interactions


PROJECT_TERMS: Behavior;Binding;Biochemical;Biological Assay;biophysical techniques;CD4 Positive T Lymphocytes;Cell membrane;Cells;Complex;Dependence;dimer;Endosomes;Ensure;Environment;Event;Exclusion;gag Gene Products;Genes;Genetic;Genetic Transcription;Genome;genomic RNA;HIV;HIV Genome;HIV-1;Human;imaging approach;imaging study;Imaging Techniques;Immune;Individual;insight;Integration Host Factors;interdisciplinary approach;Investigation;Kinetics;Knock-out;Knowledge;Length;Lipids;live cell imaging;Membrane Lipids;Methodology;Minor;models and simulation;Molecular;molecular modeling;novel;novel strategies;Nuclear Export;particle;Pathway interactions;Physiological;Play;pol Gene Products;Process;Production;protein complex;Proteins;Research Personnel;RNA;Role;scaffold;single molecule;Site;Sorting;Structural Protein;System;T-Lymphocyte;trafficking;Transcription Initiation Site;Translating;Viral;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;Virus Replication;Virus-like particle

PROJECT_TITLE: Dynamics of HIV Packaging and Assembly


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The workforce in hematology, the science of blood, has been in decline for two decades due to a variety of reasons. NHLBI has called in published articles for new research training plans for hematologists to align with the changing landscape of clinical and research hematology, including expansion of clinical-translational training. In this proposal, we leverage the extensive portfolio of clinical-translational degree programs and informal training opportunities at the University of Pittsburgh to meet the needs announced by NHLBI.

PI_NAMEs: NOVELLI, ENRICO M (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Multidisciplinary Research Training in Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Neurodegenerative diseases are imposing an increasing health and financial burden given the rapid increase of the aging segment of the population. For many neurodegenerative diseases there are no disease modifying therapeutics, including Alzheimer’s disease (AD), frontotemporal dementia (FTD) and sporadic amyotrophic lateral sclerosis (ALS). The successful demonstration that NEAT1 is altered in diseases characterized by STAU1 overabundance will lead to new potential therapeutic targets for AD, FTD, ALS and other disorders with abnormal nuclear paraspeckle function, deeper understanding on the significance of NEAT1 and STAU1 to neurodegenerative disease, and will further support STAU1 as a therapeutic target.

PI_NAMEs: SCOLES, DANIEL R (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Aging;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptosis;Attenuated;Autophagocytosis;Bacterial Artificial Chromosomes;Binding;C9ORF72;CASP3 gene;Cell Culture Techniques;Cell Line;Cell model;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Core Protein;Cortical Cord;Cytoplasm;Data;differential expression;Disease;disease model;Evaluation;Fibroblasts;Financial Hardship;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Health;heart function;Human;Hyperactivity;improved;In Vitro;in vivo Model;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;interest;Knockout Mice;Laboratories;Liquid substance;Mass Spectrum Analysis;Mediating;Messenger RNA;MicroRNAs;Molecular;Motor;motor behavior;mouse model;mRNA Transcript Degradation;mRNA Translation;Mus;mutant;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Nuclear;Nuclear Translocation;overexpression;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;Phenotype;Population;protein TDP-43;Proteins;Regulation;Reporter;RNA-Binding Proteins;Role;Safety;Small Interfering RNA;Spinal Cord;sporadic amyotrophic lateral sclerosis;Stress;Therapeutic;therapeutic target;trafficking;transcriptome;Translating;Translational Repression;Translations;Type 2 Spinocerebellar Ataxia;Untranslated RNA;Western Blotting

PROJECT_TITLE: Regulation of paraspeckles by STAU1 in neurodegenerative disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE We developed a novel metric of a person’s pace of biological aging, DunedinPoAm4x, by first tracking declines in multiple biomarkers in the cardiovascular, metabolic, pulmonary, renal, hepatic, immune, and dental systems of 1000 participants at ages 26, 32, 38 and 45 years, and then using machine-learning to convert our new metric to a new measure that can be exported to any human research sample that has blood methylation data. In this project, we will test if faster DunedinPoAm4x predicts cognitive decline, frailty, disease, and mortality, plus dementia diagnosis and MRI measures of structural brain aging; if DunedinPoAm4x is accelerated in people who grew up in adversity; if DunedinPoAm4x slows in response to beneficial lifestyle changes; and if genes relate to DunedinPoAm4x. We will deliver a reliable, valid, open-access method to measure how rapidly a person has been aging, which will be useful for basic aging research and also for testing whether a therapeutic treatment has slowed a person’s pace of aging.

PI_NAMEs: CASPI, AVSHALOM ;MOFFITT, TERRIE E (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;Affect;African American;Age;age acceleration;aged;Aging;aging brain;algorithm training;Alzheimer's disease related dementia;Benchmarking;Biological;Biological Aging;Biological Markers;Biology of Aging;biomarker panel;Blood;Blood specimen;Body System;Brain;brain magnetic resonance imaging;Cardiovascular system;Chronic Disease;Chronology;Clinical Trials;cognitive function;cohort;Consensus;Country;Data;Data Set;Dementia;Dental;design;Diagnosis;Diagnostic;Disease;DNA Methylation;epigenetic clock;Ethnic Population;Evaluation;experience;Face;follow-up;frailty;functional decline;Funding;Gene Expression;Generations;Genes;Genetic;Genetic study;Genetic Variation;genome wide association study;genome-wide;Genomic Segment;Geroscience;Goals;Growth;Health and Retirement Study;Health behavior change;health disparity;healthy aging;Hepatic;Human;Immune;immune function;Impaired cognition;Individual;Intake;Intervention;Justice;Kidney;Life Style;Longevity;Lung;Machine Learning;Magnetic Resonance Imaging;Measures;member;Mendelian randomization;Metabolic;Methods;Methylation;mild cognitive impairment;Modeling;mortality;Nature;novel;older adult;Onset of illness;optimism;Outcome;Outcome Measure;Participant;Persons;Phenotype;Physical activity;Physical Function;Physiological;polygenic risk score;Population;prospective;Proxy;psychologic;Psychosocial Deprivation;Publications;racial population;racial prejudice;rate of aging;Reporting;Research;Research Personnel;response;Sampling;Scientist;Scotland;sex;smoking cessation;System;Testing;theories;Therapeutic;tool;Training;Validation;Variant;whole genome;Work

PROJECT_TITLE: Validating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4x

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The nuclear envelope is a double lipid bilayer that separates the cytoplasm from the nucleoplasm. Proteins in the nuclear envelope are essential for maintaining nuclear structure, gene expression and chromatin organization. We study the functions of a muscle-specific nuclear envelope protein NET39 in skeletal muscle maintenance and pathogenesis of Emery-Dreifuss muscular dystrophy (EDMD). We hope to use these insights to develop new therapeutic strategies for EDMD and related skeletal muscle diseases.

PI_NAMEs: LIU, NING ;OLSON, ERIC N (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adolescent;Adult;Affect;Architecture;Biopsy;Cell Cycle Progression;Cell Nucleus;Chromatin;congenital myopathy;Cytoplasm;Defect;Development;Disease;DNA biosynthesis;DNA Damage;DNA Sequence Alteration;Emery-Dreifuss Muscular Dystrophy;env Gene Products;Foundations;Gene Delivery;Gene Expression;Gene Transfer Techniques;Genome;Goals;Homeostasis;human disease;insight;Integral Membrane Protein;Lead;Limb-Girdle Muscular Dystrophies;Lipid Bilayers;Maintenance;Mediating;Membrane Proteins;Molecular;mouse model;Mus;Muscle;Muscle function;Muscular Dystrophies;Mutation;myocyte-specific enhancer-binding-factor 2C;Myopathy;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Envelope;Nuclear Lamin;Nuclear Protein;Nuclear Proteins;Nuclear Structure;Nucleoplasm;overexpression;Pathogenesis;Pathology;Patients;Play;Progeria;Proteins;Role;segregation;single nucleus RNA-sequencing;Skeletal Muscle;Striated Muscles;Structure;Supportive care;Syndrome;Tissues;transcription factor;Work

PROJECT_TITLE: The role of nuclear envelope protein NET39 in skeletal muscle function and diseases

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Lymphatic Research;Nutrition;Obesity

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Understanding how the lymphatic system contributes to inflammatory and cardiovascular diseases remains significantly unexplored; however, recent evidence underscores important emerging roles of the lymphatic system in obesity and metabolic syndrome. This application will 1) identify the specific contribution of dysfunction of the lymphatic vasculature to metabolic dysfunction in diet-induced obesity; and 2) will test and propose novel therapeutic strategies targeting overactive Transient Receptor Potential Vanilloid 4 (Trpv4) ion channels and the Plasminogen Activator Inhibitor-1 (PAI-1), an important biomarker for disease.

PI_NAMEs: CASTORENA, JORGE AUGUSTO (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Agonist;Alzheimer's Disease;antagonist;Area;Biological Markers;Blood;Blood Vessels;Calcium;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Clinical;Confocal Microscopy;Contracts;COVID-19;Data;diet-induced obesity;Disease;Endothelial Cells;Ensure;Extracellular Matrix;Feedback;Fibrosis;Fluid Balance;Functional disorder;Health;Immune;Impairment;improved;in vivo;inducible Cre;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intercellular Junctions;Ion Channel;Ischemic Brain Injury;Link;lipid metabolism;lipid transport;Liquid substance;lung injury;Lymphatic;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphoid Tissue;Mediating;Metabolic dysfunction;Metabolic syndrome;Mus;Myography;novel therapeutic intervention;Obese Mice;Obesity;pharmacologic;Plasminogen Activator Inhibitor 1;Platelet-Derived Growth Factor alpha Receptor;pressure;prevent;promoter;protein expression;Pump;receptor;Regulation;Research;Role;Speed;Stretching;Tamoxifen;Testing;Therapeutic;Thinness;Tissues;Vanilloid;Vascular Diseases;western diet;Wild Type Mouse

PROJECT_TITLE: Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndrome

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Arthritis

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project narrative Emperipolesis is an understudied cell-in-cell interaction whereby bone marrow neutrophils transit through the cytoplasm of megakaryocytes. The PI found that emperipolesis is dramatically increased during inflammation, resulting in exchange of proteins and membrane between lineages and thereby to egressing neutrophils. This project aims to investigate how neutrophil function is modulated by emperipolesis, and to define the physiological consequences of emperipolesis in health and with inflammation.

PI_NAMEs: CUNIN, PIERRE  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Achievement;Advisory Committees;Amplifiers;Animals;Appointment;Arthritis;Autoimmune Diseases;Award;Biochemistry;Bioinformatics;Biology;Blocking Antibodies;Blood;Blood Platelets;Bone Marrow;Bone Marrow Cells;Boston;Cell Adhesion Molecules;cell behavior;Cell Nucleus;Cells;Cellular Immunology;Chemotaxis;Circulation;Confocal Microscopy;Cytoplasm;Data;Deposition;Disease;Electron Microscopy;Emperipolesis;Endothelial Cells;Endothelium;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;eptifibatide;Exhibits;exosome;Exposure to;Faculty;Flow Cytometry;Frequencies;Funding;Goals;Health;Hemostatic function;Human Biology;Hybrids;Imaging Device;Immune;immune function;Immunity;Immunology;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Institution;instructor;Interleukin-1 beta;International;intravital imaging;intravital microscopy;K/BxN model;Knowledge;Laboratories;Large Megakaryocyte;Leadership;Learning;Marrow;Mass Spectrum Analysis;Mediating;Mediator;medical schools;Megakaryocytes;member;Membrane;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Microscopy;migration;Modeling;Molecular;Molecular Biology;Mus;Myelogenous;neutrophil;Neutrophil Activation;novel;Operative Surgical Procedures;Organ;Pathologic;Pediatric Hospitals;Pediatrics;Peritonitis;Photons;Physiological;Plasma;Positioning Attribute;Process;Proteins;Reporting;Research;Research Personnel;Research Training;Role;Route;septic;Serum;skills;Slide;Source;Speed;Sterility;systemic inflammatory response;Technical Expertise;Testing;therapeutic target;Time;TNF gene;Training;training opportunity;transcriptome sequencing;Transgenic Mice;two photon microscopy;two-photon;Visualization;Work

PROJECT_TITLE: Trans-megakaryocyte migration as neutrophil amplifier

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: CLEVELAND

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance: Proteins play leading roles in the drama of life and as “actors” they mediate many critical activities such as sensing light, transporting critical nutrients, or moving muscles. Many diseases are caused by the failure of proteins to “act” appropriately and biomedical intends to understand the structures of proteins to devise strategies to correct their role in disease. This technology development project will provide novel tools to understand structures faster and more cheaply, driving accelerated research towards cures.

PI_NAMEs: KISELAR, JANNA  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Amino Acids;Antibodies;Automobile Driving;beamline;Benchmarking;Binding;Binding Proteins;Biological;Biophysics;Calmodulin;Chemicals;Chemistry;Collaborations;Communities;Complex;Coupled;Cryoelectron Microscopy;Data;Data Reporting;Deuterium;Development;Disease;Dose;Drama;Drug Design;drug discovery;Drug Targeting;Educational workshop;Estrogen Receptors;experimental study;Failure;feasibility testing;Human;Hydrogen;Hydroxyl Radical;improved;Individual;Label;Life;Ligands;Light;macromolecule;Maps;Mass Spectrum Analysis;Mediating;Membrane Proteins;Methods;Modeling;Molecular;Molecular Weight;Muscle;Myoglobin;novel;Nutrient;Oxidoreductase;Peptide Hydrolases;Peptides;Peroxides;Pharmaceutical Preparations;photolysis;Plasma;Play;Positioning Attribute;Protein Dynamics;Protein Footprinting;protein structure;Protein Tyrosine Phosphatase;Proteins;Protocols documentation;public health relevance;Publications;Reaction;Reagent;Refractory;Research;Resolution;Role;Side;Site;small molecule;solid state nuclear magnetic resonance;structural biology;Structure;Sulfur;Synchrotrons;System;Techniques;Technology;technology development;Testing;Time;tool;Training;Validation;virtual screening

PROJECT_TITLE: Multiplex labeling chemistry methods for protein footprinting

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Narrative About a decade ago we and others have exploited the simplicity for re-programming of target recognition of the RNA-guided DNA nucleases encoded by type II CRISPR-Cas immune systems (Cas9). This biotechnological application have revolutionized the study of human genetic disease and it is a testament to the importance of characterizing the molecular mechanisms of this prokaryotic immune response. In this proposal we will investigate the mechanisms of spacer acquisition of type III CRISPR-Cas systems. We believe that the knowledge generated could expand the spectrum of CRISPR-based biotechnological applications to benefit both basic and translational science.

PI_NAMEs: MARRAFFINI, LUCIANO A (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Address;adenylate;Archaea;Bacteria;bacterial community;Bacteriophages;Base Pairing;Basic Science;Binding;Biotechnology;Cells;Cellular Immunity;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Deoxyribonucleases;Development;Disease;DNA;DNA Sequence;enzyme activity;Event;experimental study;gene editing technology;gene therapy;Generations;Genes;Genetic Diseases;Genetic Transcription;Genome;Genus staphylococcus;Growth;Guide RNA;Human Genetics;human pathogen;Immune response;Immune system;Immunity;Infection;Integration Host Factors;Invaded;Investigation;Knowledge;Libraries;Lytic Phase;Mediating;Memory;Micrococcal Nuclease;Molecular;Mutagenesis;mutant;nuclease;Nucleic Acids;Periodicity;Population;prevent;Process;Production;response;Ribonucleases;RNA;RNA Phages;sample fixation;Second Messenger Systems;Single-Stranded DNA;Staphylococcus aureus;success;System;Testing;Transcript;Translational Research;Viral;Viral Genes;Viral Genome;Virus;Virus Replication

PROJECT_TITLE: Spacer acquisition during the type III-A CRISPR-Cas immune response

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: MOLECULAR MECHANISMS OF THE DYSREGULATED IMMUNE RESPONSE TO EBOLA VIRUS OVERALL: PROJECT NARRATIVE Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, is characterized by an immune response that is incapable of controlling the virus but produces inflammation that runs out of control. Our program project will provide a comprehensive picture, which is not possible with individual small projects, of how this immune response in EVD goes wrong. This will help in the search for new drugs that can improve the outcome of Ebola virus-infected individuals and may also help us understand and manage other severe hemorrhagic fevers.

PI_NAMEs: BUKREYEV, ALEXANDER  (contact);GARCIA-BLANCO, MARIANO A.

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Acute;Address;Africa;Alternative Splicing;antagonist;Apoptosis;Behavior;Bioinformatics;cell type;Cells;Cessation of life;Collaborations;Communication;Complex;COVID-19;COVID-19 pandemic;cytokine;Data;Democratic Republic of the Congo;Dendritic Cells;Development;Disease Outbreaks;Ebola Hemorrhagic Fever;Ebola virus;Ebola virus envelope glycoprotein;epidemic virus;Epigenetic Process;Evaluation;Event;Experimental Designs;experimental study;Gene Expression;gene product;Genetic Transcription;Histone Deacetylase;Human;Immune;Immune response;Immune Tolerance;improved outcome;Individual;individual response;Infection;Inflammation;Interferons;Investigation;Knowledge;Lassa virus;Lead;Lymphopenia;Marburgvirus;Mass Spectrum Analysis;Massive Parallel Sequencing;medical countermeasure;Modeling;Modification;Molecular;mRNA Translation;network models;NF-kappa B;nonhuman primate;novel therapeutics;outbreak control;Outcome;Paint;Pathogenesis;Pathogenicity;Pathologic;Phosphorylation;Population;Post-Translational Protein Processing;posttranscriptional;Program Research Project Grants;programs;proteogenomics;Public Health;Research;Research Project Grants;response;RNA;Role;Running;Sampling;Strategic Planning;T-Lymphocyte;Testing;Tissues;TLR4 gene;tool;transcription factor;Translation Alteration;Ubiquitination;Validation;Viral Hemorrhagic Fevers;Virus;Virus Diseases;Work

PROJECT_TITLE: Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus


ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Work proposed here will combine genetically encoded biosensors in a multiplexed screening assay in live cells to identify small molecule probes capable of inhibiting glucose uptake and metabolism in kinetoplastid parasites in order to develop tools for exploring this important yet incompletely understood metabolic pathway. The proposed work is impactful, as it will pioneer a new self-validating screening methodology that will yield useful tools for understanding glucose metabolism at the cellular level in a group of important early-branching eukaryotes and could also be adopted for use in other organisms. Additionally, outcomes from the research have the potential to advance treatment of neglected tropical diseases that, in some cases, have currently inadequate therapies.

PI_NAMEs: CHRISTENSEN, KENNETH A;GOLDEN, JENNIFER E.;MORRIS, JAMES CULVIN (contact);WERBOVETZ, KARL A

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adopted;Antiparasitic Agents;Area;Biological Assay;Biology;Biosensor;carbohydrate metabolism;cell type;Cells;Cellular Assay;cellular targeting;chemical property;Chemicals;Chemistry;Collection;cytotoxicity;Development;Disease;Eukaryota;Evaluation;Flow Cytometry;Fluorescence Resonance Energy Transfer;Fructose;Future;genetic approach;Gluconeogenesis;Glucose;glucose metabolism;glucose uptake;Glycolysis;Glycosome;Goals;Health;high throughput screening;Human;improved;In Vitro;Individual;inhibitor;innovation;insight;Lead;Leishmania;Leishmania donovani;Libraries;Link;Maps;Measures;member;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methods;Molecular Genetics;Monitor;multiplex assay;Nature;neglected tropical diseases;novel;novel strategies;Organism;Outcome;Outcomes Research;Parasites;Parasitic infection;pathogen;Pathway interactions;Permeability;Phenotype;Proteins;Proteomics;Pyruvate;Recombinants;Reporter;reverse genetics;Role;screening;sensor;Series;small molecule;Solubility;Stage Grouping;Time;tool;Trypanosoma brucei brucei;Validation;Visualization;Work;World Health Organization

PROJECT_TITLE: Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: Project Narrative The proposed capacity-building training program is expected to have far-reaching effects on strengthening ethical research in Pakistan. There is tremendous potential of the training imparted during this program to translate into improvement of the research culture towards greater respect for participants and communities engaged in research. The aim of research ethics is to protect and respect participants, make them partners in the research ventures, and ensure equity and accessibility in sharing of research benefits; this project will be a step in that direction.

PI_NAMEs: AHMAD, TASHFEEN ;HYDER, ADNAN A;KHAN, ROBYNA IRSHAD (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Affect;Ally;Bioethics;Biomedical Research;career;Cities;Clinical Ethics;Community Developments;community engagement;Country;COVID-19 pandemic;Crowding;Development;Discipline;Distant;Education;Educational Activities;Educational Curriculum;Elements;Enabling Factors;Ensure;Equity;Ethical Issues;Ethics;Evolution;Exercise;experience;Face;Foundations;Growth;Health;Health Professional;Healthcare;Hospital Administrators;Human;improved;information gathering;Infrastructure;innovation;Institution;Knowledge;Lawyers;Learning;Learning Module;low and middle-income countries;Manpower Need;Maps;Medical;Methods;multidisciplinary;Needs Assessment;Nurses;Organizational Ethics;Pakistan;Participant;patient engagement;pedagogy;Performance;Pharmacists;physical therapist;Physicians;Play;Policies;Policy Maker;Policy Making;Political Factor;Politics;Population;Procedures;programs;Public Health;public health ethics;Reinforcing Factor;Religion;Research;Research Ethics;Research Personnel;Resource Allocation;Resources;Role;Scientist;Services;Shapes;social;socioeconomics;Students;Time;Time Study;Training;Training Programs;Translating;Travel;Uncertainty;Universities;Visual;Work

PROJECT_TITLE: Enabling Ethical Research; A Bioethics Capacity Building Program in Pakistan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of our research is to understand the role of specific immune cells in the development of type 1 diabetes. Insights obtained from this project will improve our understanding of regulatory T cells that respond to insulin in both health and type 1 diabetes, thereby providing pathways and molecular targets to enhance regulatory T cell function to prevent type 1 diabetes onset.

PI_NAMEs: MICHELS, AARON W (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Alleles;Amino Acid Substitution;Amino Acids;anergy;Animal Model;Anti-Inflammatory Agents;antigen test;antigen-specific T cells;Antigens;Autoantigens;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;autoreactive T cell;B-Cell Antigen Receptor;Bar Codes;Binding;Biological Assay;Bystander Suppression;CD4 Positive T Lymphocytes;cell immortalization;Cell Line;Cell Physiology;Cells;Chromogranin A;Clinical;Complex;cytokine;Data;Defect;Development;Diabetes Mellitus;diabetes risk;Disease;DNA;effector T cell;enzyme linked immunospot assay;Epitopes;Event;FOXP3 gene;Funding;Gene Expression;Generations;Genetic Determinism;Goals;Health;Heterozygote;Histocompatibility Antigens Class II;HLA Antigens;Human;IL2RA gene;Immune;improved;Inbred NOD Mice;Individual;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interleukin-10;islet;Knock-out;Knowledge;Label;Lead;Link;lymph nodes;Major Histocompatibility Complex;Mediating;Molecular;molecular phenotype;Molecular Target;mouse model;Mus;non-diabetic;Organ Donor;Pancreas;Pathway interactions;Patients;Peptides;peripheral blood;Phenotype;Population;Positioning Attribute;Predisposition;prevent;Process;Proinsulin;Proliferating;Regulation;Regulatory T-Lymphocyte;Research;Resistance;response;Risk;Role;Shapes;single-cell RNA sequencing;Sorting;Specificity;T cell receptor repertoire sequencing;T cell response;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;therapy design;TNFRSF10A gene

PROJECT_TITLE: Insulin specific T cell response shaped by diabetes protective MHC class II molecules

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]