NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: RICHMOND

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Psychotic episodes are marked by substantial misperceptions of reality, disorganized or abnormal motor behavior, and formal thought disorder and can present as part of many psychiatric, neurological, and medical disorders. This proposal aims to investigate the genetic architecture of psychotic symptoms as they present in schizophrenia, schizoaffective disorder, and bipolar I disorder using sophisticated statistical approaches to derive empirical phenotypes and perform genome-wide association testing in a multi-ancestry cohort. The training, research experience, and mentorship from renown leaders in the field proposed in this award will facilitate the applicant’s career development and catalyze her transition from mentored trainee to independent investigator.

PI_NAMEs: LAPATO, DANA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Affective;African;Age of Onset;Award;Basic Science;Behavior;Behavioral;biobank;Biological;Biological Markers;Bipolar Disorder;Bipolar I;career;career development;case control;Clinical;clinically relevant;cohort;comorbidity;Complement;Country;Data;Delusions;Dementia;demographics;design;Diagnosis;Diagnostic;Diagnostic and Statistical Manual of Mental Disorders;Dimensions;Disease;disease classification;European ancestry;experience;Factor Analysis;family genetics;Foundations;Funding;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Research;Genetic study;Genetic Variation;genome wide association study;genomic data;Genomics;Goals;Hallucinations;Heritability;improved;Individual;insight;Interview;Investigation;K-Series Research Career Programs;Latinx;Lead;Major Depressive Disorder;Manic;Measures;Medical;Mental Depression;Mental disorders;Mentors;Mentorship;Meta-Analysis;Methodological Studies;Methods;Modernization;Molecular Genetics;Mood Disorders;motor behavior;National Institute of Mental Health;Nature;Neurocognitive;Neurologic;Outcome;Participant;Patients;Personal Satisfaction;Phenotype;polygenic risk score;Population Heterogeneity;psychiatric genomics;Psychiatry;psychogenetics;Psychometrics;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Publishing;Questionnaires;Research;Research Personnel;research study;Risk;Schizoaffective Disorders;Schizophrenia;Secure;sex;Signs and Symptoms;skills;social health determinants;statistics;Structure;substance use;Symptoms;Testing;Training;training opportunity;Translational Research;Twin Multiple Birth;Work

PROJECT_TITLE: Genetic architecture of transdiagnostic psychosis symptom dimensions

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Alzheimer disease (AD), a neurodegenerative disease that is the most common cause for dementia in the elderly, is characterized by a decline in mental faculties that interfere with everyday functions. AD has a crippling effect on a patient's quality of life and poses immense burdens on patients, loved ones, caretakers, and the health care system. The goal of this research is to identify new treatment strategies.

PI_NAMEs: KEILHOLZ, SHELLA D;WEINSHENKER, DAVID  (contact);WEISS, JAY MICHAEL

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;animal old age;Anti-Inflammatory Agents;Anxiety Disorders;Area;Arousal;Attention;Behavior;Behavioral Paradigm;biological adaptation to stress;Brain;Brain region;Cell Nucleus;Clinical Trials;Cognition;Cognitive;cognitive process;Data;Dementia;Depressed mood;Diagnostic;disease model;Early treatment;Elderly;Electrophysiology (science);entorhinal cortex;experimental study;extracellular;Faculty;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Healthcare Systems;Hippocampus;Human;Human Amyloid Precursor Protein;Hyperactivity;imaging study;Impaired cognition;in vivo;Inflammation;innovation;interest;Intervention;Learning;Lesion;locus ceruleus structure;loved ones;Mediating;Memory impairment;Mental Depression;Morphology;mutant;Nerve Degeneration;neurobehavioral;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neuropsychiatry;neurotoxicity;noradrenergic;Norepinephrine;norepinephrine system;novel;novel therapeutic intervention;optogenetics;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Performance;Phenotype;presenilin-1;prevent;prodromal Alzheimer's disease;promoter;Property;Prosencephalon;Psyche structure;Quality of life;Rat Transgene;Rattus;Research;Research Personnel;Rest;Rodent;Rodent Model;Senile Plaques;Severities;Sleep Disorders;Stimulus;stressor;Symptoms;targeted treatment;tau aggregation;tau mutation;tau Proteins;Testing;Therapeutic;therapeutic target;Time;tool;Transgenes;Transgenic Mice;transmission process;Viral;Viral Vector

PROJECT_TITLE: Impact of locus coeruleus-derived tau pathology in a rodent model of early Alzheimer's disease


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Palliative Care;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Among patients with metastatic cancer, an urgent need exists for primary palliative care interventions with clearly specified mechanisms and efficient delivery formats that address a range of needs within a single intervention. This study evaluates a novel multi-modal intervention that reflects each of these goals with a promising intervention approach tailored to the advance care planning and psychosocial needs of patients with metastatic cancer. The proposed clinical trial is thus designed to benefit adults with metastatic cancer, advance palliative care science, and benefit the broader healthcare system.

PI_NAMEs: ARCH, JOANNA J (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Adult;Advance Care Planning;advanced directive;Anxiety;anxiety symptoms;arm;Behavior;behavior change;cancer care;Cancer Patient;care outcomes;Clinical;clinical research site;Clinical Trials;Communities;Community Practice;Data;death anxiety;depressive symptoms;design;Disease;Disseminated Malignant Neoplasm;Distress;Dose;ethnic minority;evidence base;Evidence based intervention;experience;Face;Feedback;follow-up;Future;Goals;Health behavior;Health Status;Healthcare;Healthcare Systems;Home;improved;innovation;Institute of Medicine (U.S.);Intervention;Knowledge;Learning;Learning Skill;Life;Link;Malignant Neoplasms;Mental Depression;Metastatic to;minority communities;Modality;multi-component intervention;multimodality;novel;novel strategies;Oncology;Outcome;Outpatients;Palliative Care;participant enrollment;Patient Care;Patients;personalized approach;Persons;Pilot Projects;Population;post intervention;primary outcome;Provider;psychosocial;psychosocial outcome;psychosocial wellbeing;racial minority;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Resources;response;Risk;Science;secondary outcome;Social Workers;Solid Neoplasm;Specific qualifier value;Structure;Symptoms;Testing;theories;Therapeutic Intervention;Time;Travel;treatment as usual;Withdrawal;Work

PROJECT_TITLE: Randomized clinical trial of a multi-modal palliative care intervention

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Rehabilitation

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE Emerging evidence suggests that activation of ascending projections through the right, but not the left, vagus nerve may activate dopaminergic reward circuits within the central nervous system. These recent findings raise the intriguing possibility that electrical vagus nerve stimulation (VNS) delivered to the right cervical nerve, rather than the traditionally-targeted left cervical nerve, could be used to modulate activity within these reward networks, providing novel strategies for the treatment of movement disorders. To gain further insight into the translational potential of VNS-driven dopaminergic signaling, in the current proposal, we test the neural mechanisms that underlie the neuroplasticity-promoting and behavior-reinforcing properties of VNS, and we examine the extent to which VNS-driven activation of central reward circuits is modified by experience.

PI_NAMEs: THORN, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Behavior;Behavioral;Behavioral Paradigm;behavioral response;Biological Assay;Body Weight decreased;Cell Nucleus;Central Nervous System;Cervical;Cervical nerves;clinical development;Corpus striatum structure;Data;Dependence;Desire for food;Development;Dopamine;dopamine system;dopaminergic neuron;Dose;Effectiveness;Epilepsy;experience;experimental study;Exposure to;Extinction;FDA approved;Fiber;Food;Future;Goals;Handedness;Hunger;insight;learned behavior;Learning;Left;Literature;Liver;Major Depressive Disorder;Maps;Mediating;Metabolic;Midbrain structure;Motivation;Motor;Motor Cortex;motor disorder;motor rehabilitation;Movement Disorders;nerve injury;neural;neural network;neurobiological mechanism;neuromechanism;Neuronal Plasticity;Neurons;Nodose Ganglion;novel;novel strategies;Nucleus Accumbens;optogenetics;Organ;Pancreas;Parkinson Disease;Pathway interactions;Peripheral Nerve Stimulation;Pharmaceutical Preparations;Play;Prefrontal Cortex;Property;Psychological reinforcement;Publishing;Rattus;reinforced behavior;Research;response;Rewards;Role;Satiation;Self Administration;Signal Induction;Signal Transduction;Specificity;Stroke;stroke rehabilitation;Substantia nigra structure;System;Technology;Testing;Therapeutic;therapeutic development;translational potential;Treatment Efficacy;treatment strategy;vagus nerve stimulation;Vagus nerve structure;Variant;Ventral Tegmental Area;Viscera;Visceral;Work

PROJECT_TITLE: Peripheral nerve stimulation for activation of dopaminergic nuclei

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Liver Disease;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Echoviruses are amongst the most common human infections worldwide and are particularly dangerous in infants and neonates, in which they cause a sepsis-like disease associated with neurological complications, hepatitis, and possibly death. We propose studies to interrogate the mechanisms by which the neonatal Fc receptor (FcRn) facilitates echovirus entry, tissue tropism, and pathogenesis. These studies will provide fundamental insights into the mechanisms by which echoviruses enter cells to establish their replication.

PI_NAMEs: COYNE, CAROLYN B (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute Liver Failure;Adult;Aseptic Meningitis;Biology;Bypass;cell type;Cells;Cessation of life;Dangerousness;Data;defined contribution;Development;Disease;Echo Viruses;Echovirus 9;Echovirus Infections;Ectopic Expression;Encephalitis;Endothelial Cells;enteric infection;Enterocytes;Enterovirus;Epithelial Cells;Exhibits;experimental study;Fc Receptor;Genes;Goals;Hepatic;Hepatitis;Hepatocyte;Homologous Gene;Human;human stem cell-derived;In Vitro;in vivo;in vivo Model;Individual;Infant;Infection;Infectious Agent;innovation;insight;Integration Host Factors;intestinal epithelium;Intestines;Kupffer Cells;Liver;liver infection;Mediating;Meningitis;Modeling;Molecular;Monoclonal Antibodies;monolayer;mortality;mouse model;Mus;Nature;Neonatal;neonatal Fc receptor;neonatal mice;neonatal morbidity;Neonatal Mortality;neonate;Nervous System Disorder;Neurologic;novel;particle;Pathogenesis;permissiveness;Physiological;Play;Population;Positioning Attribute;prevent;Proteins;Reagent;receptor;receptor binding;receptor expression;receptor internalization;Recombinants;Research;Role;Route;Sepsis;Serotyping;Site;Specificity;stem cell model;Subgroup;therapeutically effective;tissue tropism;Tissues;trafficking;transcytosis;Transgenic Organisms;Tropism;Viral;Virus;virus tropism

PROJECT_TITLE: The Role of FcRn in Echovirus Entry and Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE This project will expand the acquisition, reconstruction, analysis, and immediate dissemination of 3D electron microscopic (3D EM) reference data, disclosing key ultrastructural details preserved within a remarkable collection of legacy biopsy brain samples from patients suffering from Alzheimer’s Disease (AD). Our focus is to examine regions of acute interest, based on our own observations and insight offered from current AD literature, at a resolution sufficient to quantitatively assess suggested markers of AD-associated pathogenesis, link to biochemical data on molecular structures from studies on humans and mouse models of AD, and motivate future hypothesis driven research.

PI_NAMEs: ELLISMAN, MARK H (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Acute;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid Fibrils;Archives;Area;Award;Axon;axonal degeneration;Back;Binding;Biochemical;Biopsy;Biopsy Specimen;Brain;brain cell;brain tissue;brain volume;Carotid Artery Ulcerating Plaque;Cataloging;Cell Nucleus;Cells;cellular imaging;cellular targeting;Cerebrospinal Fluid;Chromatin;Collection;Communities;convolutional neural network;Cytoplasm;Cytoskeletal Filaments;Cytoskeleton;Data;data acquisition;Data Analyses;data mining;Data Set;Dedications;deep learning;Dendrites;Electrons;Endoplasmic Reticulum;Face;Funding;Future;Goals;Golgi Apparatus;Human;human model;image archival system;imaging Segmentation;Infusion procedures;insight;interest;Investigation;Link;Literature;Location;Manuals;Maps;Measures;Methods;Microscopic;microscopic imaging;Microtubules;Mitochondria;Modification;Molecular Structure;mouse model;Nerve Degeneration;Neurites;Neurofibrillary Tangles;Neuroglia;neuronal cell body;Neurons;Nuclear Pore;open source tool;Organelles;Output;paired helical filament;Parents;Pathogenesis;Performance;Pharmaceutical Preparations;preservation;Process;Production;reconstruction;Reporting;Request for Applications;Research;Research Personnel;Resolution;Running;Sampling;Scanning Electron Microscopy;Staging;Structure;Surveys;Synapses;Thick;Tissues;tomography;Training;training data;transmission process;United States National Institutes of Health;web portal;Work

PROJECT_TITLE: 3D Reconstruction and Analysis of Alzheimer's Patient Biopsy Samples to Map and Quantify Hallmarks of Pathogenesis and Vulnerability

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative It would be advantageous to be able to treat neurodegenerative diseases and brain injuries using cells resident in the brain as versus transplanted stem cells. We have developed a novel neurogenesis paradigm in the adult brain of the genetic model organism Drosophila melanogaster and are using this model to explore the molecular mechanisms underlying brain regeneration. The goals of the experiments proposed in this application are to elucidate the role of glia cells in facilitating neurogenesis and to identify signaling pathways that trigger the regenerative cascade. Because of the extensive genetic parallels underlying Drosophila and mammalian brain development, we anticipate that our discoveries will be clinically relevant.

PI_NAMEs: BOEKHOFF-FALK, GRACE E (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acceleration;Address;Adult;adult neurogenesis;Affect;Apoptosis;Axon;Behavior;Behavioral;Behavioral Assay;Brain;brain cell;Brain Injuries;Candidate Disease Gene;candidate identification;Cell Death;Cell Proliferation;Cells;Circadian Rhythms;clinical application;clinically relevant;Compensation;Cyclin-Dependent Kinase Inhibitor;Data;Dendrites;Development;Drosophila genus;Drosophila melanogaster;experimental study;Gene Expression;Generations;Genes;Genetic;Genetic Models;gliogenesis;Goals;Human;immunodeficiency;Immunohistochemistry;Injury;injury recovery;Innate Immune System;innovation;knock-down;Knowledge;Label;Laboratories;Locomotor Recovery;Mediating;Medical;model organism;Modeling;Molecular;mutant;Natural Immunity;Natural regeneration;Nerve Regeneration;nerve stem cell;neural;neural circuit;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuron regeneration;Neurons;Neuropil;novel;Optic Lobe;Pathway interactions;Population;progenitor;Proliferating;Recovery of Function;regenerative;Reporting;response;RNA Interference;Role;Signal Pathway;Stem cell transplant;Testing;Therapeutic;therapeutic target;Time;timeline;Work

PROJECT_TITLE: Neurogenesis in the adult Drosophila brain

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Narrative Therapeutic exploitation of oncogene addiction has become a central aim of modern cancer therapy, but effective targeted therapies for chemotherapy resistant and/or relapsed hematopoietic malignancies including acute myeloid leukemia (AML) are lacking. In this proposal, a collaborating team of experts will investigate whether a valid approach for therapeutic interventions in AML can be based on a strategy to inhibit supportive non-oncogene addiction pathways, interfering with tumor-promoting metabolic reprogramming and improving the predicted power of anti-tumor immunity through depletion of Hsf1. This effort may provide an advancement to overcome key existing barriers in refractory AML management.

PI_NAMEs: MIVECHI, NAHID F (contact);MOSKOFIDIS, DIMITRIOS

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Accounting;Acute leukemia;Acute Myelocytic Leukemia;adaptive immunity;Adoptive Transfer;Adult;anti-tumor immune response;Antigens;Applications Grants;Attenuated;Automobile Driving;Bioenergetics;cancer cell;Cancer Patient;cancer regression;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;cell transformation;Cells;Cellular Immunity;Cellular immunotherapy;Cessation of life;Chemoresistance;chemotherapy;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;chromatin modification;Clinical;clinical efficacy;Clinical Trials;clinically significant;Collaborations;Development;Diagnosis;Disease remission;Drug resistance;Effector Cell;Elderly;Epigenetic Process;epigenetic regulation;exhaustion;Exhibits;Experimental Designs;experimental study;fitness;Functional disorder;Generations;Genes;Genetic;genetic signature;Genetic Transcription;genotoxicity;heat shock transcription factor;Heat-Shock Response;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Human;Human Engineering;Immune;Immunity;Immunologic Surveillance;immunological intervention;Immunotherapeutic agent;Immunotherapy;improved;individual patient;leukemia;leukemia relapse;leukemia treatment;Leukemic Cell;liquid chromatography mass spectrometry;long term memory;Malignant - descriptor;Malignant Neoplasms;Mass Fragmentography;Mediating;Memory;Metabolic;metabolic profile;Metabolism;metabolomics;Modernization;Molecular;mouse model;Mus;Mutation;Myeloproliferative disease;novel;novel strategies;novel therapeutic intervention;novel therapeutics;oncogene addiction;Oncogenes;Oncogenic;Outcome;Pathogenesis;Pathway interactions;Patients;Physiology;Population;preclinical study;prevent;progenitor;Prognosis;programs;protein folding;Proteins;Proteome;Recurrence;Refractory;Regulation;Relapse;Remission Induction;Research;Resistance;Role;Sampling;Signal Transduction;stem;stemness;Stress;Study models;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Toxic effect;transcription factor;translational goal;treatment strategy;tumor;Tumor Immunity;Tumor Promotion;tumorigenesis

PROJECT_TITLE: Role of heat shock transcription factors (HSFs) in hematological malignancies

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE As Africa’s most populous country, Nigeria is facing the threats of high HIV burden, low combination antiretroviral treatment (ART) coverage, and slow decline in new HIV infections. The need to develop research capacity to generate evidence to tackle the burden of HIV in Nigeria is great, and biostatistics expertise and leadership, which is lagging in West Africa, is critical to these research activities. In response to this need, the Vanderbilt- Nigeria Biostatistics Research Training Program (VN-BioStat) harnesses the longstanding and highly successful research partnership between Aminu Kano Teaching Hospital, Bayero University Kano, and the Vanderbilt Institute for Global Health to establish a research and training platform that will create a cohort of highly skilled Nigerian biostatistics leaders with the capacity to lead independent and collaborative research focused on HIV.

PI_NAMEs: ALIYU, MUKTAR HASSAN;HUSSAINI, NAFIU ;SHEPHERD, BRYAN EARL (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academic Medical Centers;Address;Africa;Big Data;Biomedical Research;Biometry;Clinic;Clinical Investigator;cohort;Collaborations;Data;Data Scientist;design;Doctor of Philosophy;Educational workshop;Faculty;Funding;global health;Grant;HIV;HIV/AIDS;Hour;Institution;Joints;Lead;Leadership;Mentorship;Methodology;Methods;Modeling;Nigeria;Nigerian;Parents;Principal Investigator;programs;Publications;Research;Research Personnel;Research Project Grants;Resources;skills;Southern Africa;statistics;Survival Analysis;Teaching Hospitals;Training;Training Programs;United States;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Vanderbilt-Nigeria Biostatistics Training Program (VN-BioStat)


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Cytomegalovirus can cause serious health problems and life-threatening disease in newborns and immune- suppressed individuals (including cancer and transplant patients). This grant renewal seeks to understand the transcriptional and epigenetic regulation underlying natural killer (NK) cell-mediated control of viral infection. Defining the molecular mechanisms by which NK cells respond to pathogens will lead to new therapies.

PI_NAMEs: SUN, JOSEPH CHAI-YUEN (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Activated Natural Killer Cell;Adaptive Immune System;adaptive immunity;aerobic glycolysis;Antigens;Apoptosis;Automobile Driving;Autophagocytosis;B-Lymphocytes;Binding;Binding Sites;Biological;Cancer Patient;Cell Physiology;Cell Survival;Cells;ChIP-seq;Chromatin;Clinical;Clonal Expansion;Communicable Diseases;comparative;conditional knockout;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;cytotoxicity;Data;Development;Disease;DNA Binding;DNA Binding Domain;Effector Cell;Epigenetic Process;epigenetic regulation;Excision;Exhibits;experimental study;Family;Funding;Gene Targeting;Genes;Genetic Transcription;Glycolysis;Goals;Grant;Health;Helix-Turn-Helix Motifs;Herpesviridae;Human;Immune;Immunocompromised Host;Immunologic Memory;Immunoprecipitation;In Vitro;in vivo;Individual;Inflammatory;Innate Immune Response;innovation;Interferon Type II;Invaded;IRF4 gene;Knockout Mice;Life;Ligation;Lymphocyte;Lymphoid;Mass Spectrum Analysis;Measures;Mediating;member;Memory;Metabolic;Metabolic Control;Metabolism;metabolomics;Mitochondria;mitochondrial autophagy;Modeling;Molecular;Monkeys;Murid herpesvirus 1;Mus;Natural Immunity;Natural Killer Cells;Newborn Infant;NF-kappa B;NK Cell Activation;novel;novel therapeutics;pathogen;Pathway interactions;permissiveness;Play;Predisposition;progenitor;Proliferating;Proteomics;receptor;Regulation;Reporter;response;Role;Specificity;System;T-Lymphocyte;Testing;Therapeutic;trait;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Mice;Transgenic Organisms;Transplant Recipients;United States National Institutes of Health;Viral;Virus;Virus Diseases;Winged Helix;Work

PROJECT_TITLE: The natural killer cell response against mouse cytomegalovirus infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Enterotoxigenic Escherichia coli (ETEC) cause hundreds of millions of diarrheal cases among young children in developing countries leading to hundreds of thousands of deaths annually as well as an enormous burden of poorly understood complications including malnutrition, impaired growth, and poor intellectual development. This project will investigate molecular mechanisms responsible for ETEC-induced damage to intestinal surfaces responsible for nutrient absorption.

PI_NAMEs: FLECKENSTEIN, JAMES MICHAEL (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute Diarrhea;Address;Adult;Affect;Age;Architecture;Area;Atrophic;Attention;Automobile Driving;base;beta catenin;Biogenesis;Biological Assay;Biology;Brush Border;cell type;cellular microvillus;Cessation of life;Characteristics;Child;Cholera;Chromatin;Clinical;Country;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Data;Dehydration;Developing Countries;Development;Diagnosis;Diarrhea;diarrheal disease;Disadvantaged;Disease;Enteral;Enterocytes;enterotoxigenic Escherichia coli;Epigenetic Process;Epithelial Cells;Epithelium;Escherichia coli Infections;Essential Genes;Exposure to;Fingers;Fostering;Functional disorder;Gene Expression;Genes;Genetic Transcription;Growth;Health;human capital;Hyperplasia;Impairment;In Vitro;in vivo;Individual;Infection;insight;Intellectual impairment;intestinal epithelium;intestinal homeostasis;intestinal maturation;Intestines;Investigation;Ion Channel;Knowledge;Life;Link;low and middle-income countries;Maintenance;Malnutrition;Mediating;meter;Molecular;Morbidity - disease rate;Morphology;mortality;mortality risk;mouse model;Nature;neonatal mice;Nutrient;nutrient absorption;Oral Rehydration Therapy;pathogen;Pathogenesis;Pathway interactions;Patients;Phosphorylation;Play;Pneumonia;prevent;Process;Production;Proliferating;protein activation;Protein Kinase;Resource-limited setting;Risk;Role;Sanitation;Second Messenger Systems;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;Sodium Chloride;stem cell differentiation;Surface;Testing;Toxin;Toxoids;transcriptome;Transposase;Tropical sprue;Vaccination;Vaccines;Villus;wasting;Water;Work

PROJECT_TITLE: Molecular Pathogenesis of enterotoxigenic E. coli associated enteropathy

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Mucociliary Innate Defense Mechanism in the Human Distal Airway Project narrative Airway mucociliary clearance is a regionally coordinated critical innate defense system for maintenance of lung health, with failure of this system being a common feature of muco-obstructive lung diseases. Our overarching goal is to gain mechanistic insights into region-specific mucociliary innate defense mechanisms with a focus on small airways that are characterized as the earliest, most affected region in muco-obstructive lung diseases. Achievement of our goal should provide a new paradigm in our understanding of mucociliary clearance system in the lung and how to approach novel therapies for muco-obstructive lung diseases. 1

PI_NAMEs: OKUDA, KENICHI  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: absorption;Achievement;Affect;Air Movements;airway epithelium;airway surface liquid;Anatomy;Area;Asthma;Biopsy Specimen;Canis familiaris;Cell Density;cell type;Cells;Chronic Bronchitis;Cilia;cost;Coughing;Coupled;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Reporting;Defense Mechanisms;Diameter;Dimensions;Disease;Distal;Epigenetic Process;Epithelial Cells;Equilibrium;Exhibits;Failure;Fluids and Secretions;Functional disorder;Gland;Goals;Health;Homeostasis;Human;Hydration status;Image;in vivo;Inhalation;insight;Ion Transport;Ions;Knowledge;Lead;Lung;lung health;Maintenance;Mediating;Metabolic Clearance Rate;Microdissection;Modeling;Mucins;Mucociliary Clearance;Mucous body substance;mucus clearance;mucus-associated lung diseases;multiple omics;novel therapeutic intervention;Obstruction;Pathogenesis;Pathology;Pathway interactions;Physiology;prevent;Production;Property;pulmonary function;regional difference;Regulatory Element;Reporting;Role;Sampling Studies;Solid;Specificity;Stress;Submucosa;Surface;System;Techniques;Testing;Tissues;toxicant;Transcriptional Regulation;transcriptome

PROJECT_TITLE: Mucociliary innate defense mechanism in the human distal airway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The amygdala is considered a hub for emotional processing in the brain, and a large body of clinical research implicates it in anxiety disorders, PTSD, other disorders involving emotional dysfunction, and newer research suggests it even plays a key role in sudden unexpected death in epilepsy (SUDEP), the leading cause of death in patients with temporal lobe epilepsy. The amygdala is a heterogeneous structure, though the majority of human amygdala studies do not analyze data from its many subregions separately, limiting our understanding of the specific roles that these subregions play in clinical diseases that affect the amygdala. We plan to conduct a thorough characterization of the anatomical and functional properties of the subregions of the human amygdala, with a special focus on those receiving direct projections from the olfactory bulb, areas which have been implicated in SUDEP, ultimately providing some of the first detailed explorations of human amygdala subregions that are implicated in this disease.

PI_NAMEs: ZELANO, CHRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Accessory Olfactory Bulbs;Address;Affect;Algorithms;Amygdaloid structure;Anatomy;Anterior;Anxiety Disorders;Area;Behavior;Brain;Brain region;Cause of Death;Cell Nucleus;Clinical;Clinical Protocols;Clinical Research;Code;Data;Diffusion Magnetic Resonance Imaging;Disease;Electric Stimulation;Electroencephalography;Electrophysiology (science);Emotional;Event;Exhibits;experimental study;Fiber;Food;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Human;Lateral;Measures;Medial;Mediating;Methods;neural;neuroimaging;novel;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;Olfactory tract;Patients;Pattern;Play;Post-Traumatic Stress Disorders;Property;Psychophysics;Reproducibility;Research;Resolution;Rest;Rodent;Role;Series;Signal Transduction;Smell Perception;social;Structure;sudden unexpected death in epilepsy;Techniques;Temporal Lobe Epilepsy;Testing;Time

PROJECT_TITLE: Characterizing the primary olfactory subregions of the human amygdala

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE For many patients suffering from psychiatric illness, the main source of daily-life distress is inner experiences that often seem to occur “on their own” to the detriment of mental health, such as dwelling uncontrollably on something negative that occurred in the past. We currently do not fully understand how these inner experiences are generated from activity in the brain, and so psychiatric treatments cannot be designed to target the biological processes that cause distressing, uncontrollable, inner experiences. To address this gap of knowledge, we will develop and apply a new method—based on real-time, immediate analysis of brain signals while they are being recorded—to efficiently discover reliable relationships between patterns of activity in the brain and the inner (including distressful) experiences that people are having.

PI_NAMEs: KUCYI, AARON  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Adult;Affect;Affective;Anterior;Appearance;Arousal;Attention;Biological Process;blood oxygen level dependent;Brain;Brain region;Coupled;Coupling;Data;design;Detection;Development;Diagnostic;Distress;Dorsal;Electrophysiology (science);Event;experience;Functional Magnetic Resonance Imaging;Hallucinations;High Prevalence;Human;insight;interest;Investigation;Knowledge;Life;locus ceruleus structure;Maps;Mediating;Mental disorders;Mental Health;Methods;Modality;Mydriasis;negative affect;neural;neural circuit;Neurons;neurophysiology;neuroregulation;Normal Range;novel;novel strategies;novel therapeutics;Participant;Patient Self-Report;Patients;Pattern;Persons;Pharmacotherapy;Physiological;Population;Process;Protocols documentation;Psychiatric Diagnosis;Psychiatric therapeutic procedure;psychologic;Reporting;Research;Resistance;Rest;rumination;Sampling;Scanning;Signal Transduction;Source;standard care;Structure;System;Testing;therapy design;therapy development;Thinking;Time;Visual

PROJECT_TITLE: Real-time fMRI for insular cortex brain state-triggered experience sampling

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This project seeks to characterize transmitral vortex flow as a link to discovering novel approaches for heart valve tissue engineering to enhance tissue generation and cell viability of the engineered leaflets. We will test the overarching hypothesis that the reciprocal effects between non-axisymmetric vortex flow and mitral TEHVs' scaffold geometry and annulus dynamics enhance tissue generation and improve the valve's cell viability.

PI_NAMEs: KHERADVAR, ARASH  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Aorta;Aortic Valve Stenosis;Artificial Heart;attributable mortality;Autologous;Biological;Bioprosthesis device;Blood;Blood flow;calcification;Cardiac;cardiac tissue engineering;Cell Survival;Cells;Clinical;conditioning;design;Developing Countries;Development;Disease;Endothelial Cells;Engineering;Extracellular Matrix;Generations;Geometry;Heart;Heart Diseases;Heart Valve Diseases;Heart Valves;hemodynamics;Homeostasis;Human;Hybrids;Implant;implantation;improved;In Vitro;in vivo;insight;interstitial cell;Left;Left atrial structure;Left ventricular structure;Life Expectancy;Link;Long-Term Effects;Mitral Valve;Mitral Valve Stenosis;Morbidity - disease rate;Nature;next generation;novel strategies;Patients;Performance;Phenotype;Platelet aggregation;Positioning Attribute;Pre-Clinical Model;preclinical study;pressure;prevent;prototype;Recommendation;Regimen;Reproducibility;Rheumatic Heart Disease;Risk;scaffold;Shapes;Sheep;sheep model;Stress;Testing;Thick;Thinness;Thromboembolism;Thrombosis;Tissue constructs;Tissue Engineering;tissue regeneration;Tissues;United States;valvular insufficiency;Ventricular;young adult

PROJECT_TITLE: Reciprocal effects between scaffold geometry and ventricular vortex flow on viability and performance of tissue-engineered mitral valve

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Enzymes that bind iron–sulfur clusters are found in all kingdoms of life and perform reactions that play central roles in human health, including the generation of ammonia fertilizer from air. We propose to study the chemical bond-making and -breaking steps of these reactions by developing methods for modifying the isotopic and elemental compositions of their catalytic clusters.

PI_NAMEs: SUESS, DANIEL LEIF MIGDOW (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Chemical Approaches to Studying the Mechanisms and Biophysical Properties of Complex Metallocofactors

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The changes in brain circuit activity required to generate sickness symptoms are critical for survival during acute infection. Moreover, a greater understanding of sickness-related changes in brain activity will likely inform upon chronic disease states that are characterized by miscommunication or overactivation of immune signals in the brain such as depression, Alzheimer’s disease, Parkinson’s disease and epilepsy. Thus, uncovering the cell types and brain circuits activated during sickness is critical to understanding brain function in normal and pathological contexts.

PI_NAMEs: OSTERHOUT, JESSICA ALLISON (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;acute infection;adaptive immune response;Adipose tissue;Advisory Committees;Alzheimer's Disease;Animals;appetite loss;Area;Attenuated;attenuation;Award;Behavior;Behavioral;Body Temperature;Brain;brain cell;brain circuitry;Cell Survival;cell type;Chronic Disease;Communication;cytokine;Dinoprostone;Epilepsy;experimental study;feeding;Fever;Future;Gene Expression;Generations;Genes;Genetic;genetic approach;glial activation;Goals;Hypothalamic structure;Immediate-Early Genes;immune activation;Immune response;Immune signaling;Immunologic Factors;Induced Hyperthermia;Induced Neurons;inducible Cre;Infection;Inflammatory;inhibitor;Injections;Innate Immune Response;Invertebrates;Knock-out;Laboratories;Lethargies;Lipopolysaccharides;Measures;Medial;Mediating;Mental Depression;Mentors;Methods;Molecular;Mus;Nervous System;neural circuit;Neuroglia;neuronal circuitry;Neurons;novel therapeutics;Optics;Parkinson Disease;Pathologic;Pathway interactions;Pattern;Phase;Physiology;Play;Population;Positioning Attribute;Preoptic Areas;promoter;Prostaglandin Receptor;Prostaglandins;Proteins;rabies viral tracing;receptor;Reporting;Reptiles;Research;response;Role;Scientist;single nucleus RNA-sequencing;skills;Stereotyping;Symptoms;Synapses;Techniques;Technology;Testing;Thermogenesis;tool;Training;Translating;Universities;Viral;Vocational Guidance;Work

PROJECT_TITLE: Characterization of the molecular and cellular mechanisms underlying the sickness symptoms

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

ORG_ZIPCODE: SW7 2AZ

PHR: Group A Streptococcus is an exclusively human pathogen that can cause both simple pharyngitis, that is treatable with antibiotics, to life-threatening necrotizing fasciitis and other invasive infections including toxic shock. Furthermore, repeated episodes of streptococcal pharyngitis can lead to autoimmune rheumatic heart disease, causing almost half a million deaths per year globally. Pharyngitis represents the main reservoir or starting point for these severe consequences, therefore our proposal to devise a broad-acting RNA vaccine, comprising an optimized combination of antigens to prevent streptococcal pharyngitis, will have a major positive impact on public health in both the domestic and global setting.

PI_NAMEs: SHATTOCK, ROBIN J;SRISKANDAN, SHIRANEE  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute Disease;Address;Adult;Antibiotics;Antibodies;Antigens;antimicrobial;Autoimmune;Autoimmune Responses;Bacterial Infections;Blood;Cessation of life;Child;Chronic Disease;Clinical;combat;Combined Vaccines;Computer Assisted;Consumption;Coupled;Development;Disease;Economic Burden;experimental group;Experimental Models;Foundations;Fright;Future;Genetic Recombination;Genome;Genotype;Goals;Health;health economics;Horizontal Gene Transfer;Human;human pathogen;Immune;Immunity;Immunization;Immunoglobulins;in vivo;Individual;Infection;innovation;interest;Intravenous Immunoglobulins;Investigation;lead candidate;Life;Methodology;Modeling;mortality;mouse model;multiple myeloma M Protein;Mus;Mutation;Nasopharynx;Necrotizing fasciitis;Nose;pathogen;Pharyngitis;Predisposition;Preparation;prevent;protective efficacy;Proteins;Public Health;Rheumatic Fever;Rheumatic Heart Disease;Risk;Risk Reduction;RNA amplification;RNA vaccine;Series;Serotyping;socioeconomics;soft tissue;Soft Tissue Infections;Streptococcal Infections;Streptococcus;Streptococcus pyogenes;System;Technology;Testing;Toxic Shock Syndrome;Vaccinated;Vaccine Antigen;vaccine development;vaccine discovery;Vaccines;Work

PROJECT_TITLE: An RNA vaccines systems approach to Group A streptococcus vaccine discovery


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: UNIVERSITY OF NAIROBI

PHR: PROJECT NARRATIVE Strong research administration and management infrastructure is critical to ensuring donor and institutional funds are effectively deployed for high priority HIV research targeted to reduce the incidence of HIV, developing next-generation therapies for HIV, enhancing UoN ability to conduct research toward an HIV cure. The purpose of this project to be implemented at the University of Nairobi is to strengthen scientific capacity to conduct HIV research in Kenya by enhancing knowledge and skills gaps among research administrators at UoN and its collaborating institutions through the Center for Research Innovation and Grants Advancement (CERIGA) for effective research administration and management at the University of Nairobi and its research partners in Kenya. Building on previous investment, in collaboration with University of Washington, this project will provide an opportunity to operationalize the CERIGA Strategic Plan towards supporting the general business management practices necessary for the effective management and compliance required for donor funding policies. Page 2 of 77

PI_NAMEs: M'IMUNYA, JAMES MACHOKI (contact)

PROJECT_TERMS: Administrator;AIDS prevention;Award;Basic Science;burden of illness;Businesses;Clinical Research;Collaborations;Communication;Country;Development;Ensure;Epidemic;epidemic response;Ethical Review;Evaluation;Extramural Activities;Faculty;Funding;Funding Opportunities;Goals;Grant;Guidelines;HIV;HIV Infections;HIV therapy;Human Resources;human subject protection;implementation research;improved;Incidence;Infection;Infrastructure;innovation;Institution;institutional capacity;International;Investments;Kenya;Knowledge;Medical Education;Mentorship;Monitor;mortality;next generation;Occupational activity of managing finances;Office of Administrative Management;Outcome;Play;Policies;Practice Management;Prevention;Process;programs;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Role;Scientist;skills;Strategic Planning;systems research;Targeted Research;technology platform;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Update;Washington;Work

PROJECT_TITLE: Strengthening Research Administration and Management for Critical HIV Research in Kenya (STRAM-CHR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Public Health Relevance: Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by progressive memory and cognitive deficit with impairment of glutamatergic neural circuits. An estimated 5.5 million Americans have AD and the number is expected to rise as the population ages (aging is the major risk factor for AD) with an enormous psychological and economical impact in society. There is a great unmet need to advance our pathophysiological understanding of vulnerable glutamatergic neural circuits to AD, as proposed in this study, which would not only provide important clues on the mechanisms of disease pathogenesis and progression, but could also point to novel and more effective treatment targets.

PI_NAMEs: PEREIRA, ANA C. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Affinity Chromatography;Age;age acceleration;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;American;association cortex;Autopsy;Bacterial Artificial Chromosomes;Behavioral;Brain;Brain region;brain tissue;cell type;Cells;cerebral atrophy;Cessation of life;Chemicals;Cognitive deficits;Data;Development;Disease;Disease Progression;economic impact;effective therapy;entorhinal cortex;Excitatory Amino Acid Transporter 2;excitatory neuron;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic;Glutamate Transporter;Glutamates;Goals;Heterogeneity;hippocampal pyramidal neuron;Hippocampus;Human;human disease;hyperphosphorylated tau;Immune System Diseases;Impaired cognition;Impairment;indexing;Inflammation;Inflammation Mediators;inhibitory neuron;innovation;insight;Internal Ribosome Entry Site;Interneurons;knock-down;Learning;MAPT gene;Mediating;Memory;Memory impairment;Messenger RNA;Methodology;Modeling;Molecular;Motor Cortex;mouse model;Mus;mutant;Neocortex;neocortical;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neuronal Differentiation;Neurons;neurotoxicity;new therapeutic target;novel;overexpression;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;patient derived induced pluripotent stem cells;Physiological;Play;Population;Predisposition;Prefrontal Cortex;Psychological Impact;psychosocial;public health relevance;Reporter;Resected;resilience;Resistance;Ribosomes;Riluzole;Role;single cell sequencing;single-cell RNA sequencing;Societies;Suspensions;Synapses;Synaptic Cleft;tau aggregation;tau mutation;tau Proteins;Tauopathies;Techniques;Testing;therapeutic target;therapeutically effective;Toxic effect;transcriptomics;Translating;uptake;Validation;Viral;Viral Vector;Visual Cortex

PROJECT_TITLE: Mechanisms of Susceptibility of Excitatory Neurons to Tau Pathology and Neurodegeneration in Alzheimer's disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Immunotherapy has advanced the treatment of solid cancers and lymphoblastic leukemia/lymphoma, but in colon rectal cancer, a leading cancer among both men and women, cure rates remain at only 50%. Therefore, additional pathway inhibitions are needed such as the ST2/IL33 pathway. This study will establish a novel target and provide initial findings how to improve colorectal cancer immunotherapy responses.

PI_NAMEs: VAN DER JEUGHT, KEVIN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Affect;anti-PD-1;anti-PD1 therapy;Antibodies;Antigen Presentation;antigen-specific T cells;Antigens;Award;Binding;Bioinformatics;Biological Assay;Biomedical Engineering;Cancer Biology;cancer cell;cancer immunotherapy;cancer stem cell;cancer vaccination;career;CD47-SIRPα;CD8-Positive T-Lymphocytes;Cell Line;cell mediated immune response;Cell Reprogramming;Cells;checkpoint therapy;Chimeric Proteins;Clinical;clinical investigation;Collaborations;Colon;colon cancer patients;Colorectal Cancer;Communication;Complex;cytokine;cytotoxic CD8 T cells;cytotoxicity;Data;deprivation;design;Development;Discipline;Environment;experimental study;Goals;Human;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunology;Immunosuppression;Immunotherapy;improved;Indiana;Infiltration;insight;interest;Interleukin Activation;Interleukins;Investigation;Journals;Knockout Mice;Knowledge;Legal patent;leukemia/lymphoma;Literature;Lymphoblastic Leukemia;Macrophage;Malignant Neoplasms;Manuscripts;Mediating;Memory;men;Microsatellite Instability;Microscopy;Modeling;Molecular;Molecular Profiling;Mus;nano;Nanotechnology;Nature;neoplastic cell;novel;Outcome;Paper;Pathway interactions;Patients;Phagocytosis;Phenotype;Play;Postdoctoral Fellow;Productivity;programs;Publishing;receptor;Rectal Cancer;Recurrent disease;Reporting;Research;Research Peer Review;Research Personnel;Resistance;response;Role;Sampling;Scientist;SHPS-1 protein;Signal Transduction;skills;small molecule inhibitor;Solid;stem cells;T cell response;T-Lymphocyte;Technology;Therapeutic;Therapeutic Uses;tissue stress;Training;transcriptome sequencing;translational potential;Treatment Protocols;tumor;Tumor Antigens;tumor growth;tumor immunology;tumor microenvironment;Tumor-associated macrophages;Universities;vaccination strategy;Woman

PROJECT_TITLE: Targeting the IL-33/ST2 Pathway in Colorectal Cancer Immunotherapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Immunotherapy

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Diacylglycerol kinases (DGKs) are critical regulators of lipid signaling in mammalian biology and have remained elusive drug targets. We propose the use of functional proteomics/metabolomics to address fundamental questions regarding DGK ligand binding, diacylglycerol fatty acyl specificity, and druggability in T cells. The overall impact of our findings is to enable new biological discoveries to broadly impact drug discovery of the DGK superfamily.

PI_NAMEs: HSU, KU-LUNG  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Active Sites;Address;Affect;Anabolism;Animals;Architecture;Attenuated;Azoles;Binding;Binding Sites;Biochemical;Bioenergetics;Biological;Biological Assay;Biology;candidate identification;Catalytic Domain;CD8B1 gene;Cell membrane;Cell Physiology;Cells;Cellular biology;Chemicals;chemotherapy;Clinical;Code;Combination immunotherapy;Coupling;DAG/PE-Binding Domain;Development;Diacylglycerol Kinase;Diglycerides;Disease;drug discovery;Drug Targeting;Environment;Enzymes;experimental study;extracellular;Family;Genetic;Goals;Human;Immunosuppression;Immunotherapy;Impairment;in vivo;Individual;inhibitor;insight;interest;Investigation;kinase inhibitor;Knock-out;Knowledge;Ligand Binding;Ligands;Link;lipid metabolism;lipidome;lipidomics;Lipids;Location;Lysine;Mammals;MAP Kinase Gene;Maps;Mediating;Membrane;Metabolic;Metabolism;metabolomics;Methods;mimetics;Modeling;Modification;Molecular;mouse model;Mutation;novel;Organism;Outcome Study;overexpression;pharmacologic;Phosphatidic Acid;Phospholipids;Phosphorylation;Phosphotransferases;programs;Protein Engineering;Protein Isoforms;Protein Kinase;Proteins;Proteome;Proteomics;receptor;Receptor Signaling;Recombinants;Regulation;Reporting;Research;response;Role;Series;Shapes;Signal Transduction;Site;small molecule;Specificity;Substrate Specificity;System;T cell regulation;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic target;transcription factor;Translating;Triglycerides;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Tyrosine;VAV1 gene

PROJECT_TITLE: Chemical proteomic investigation of lipid kinase specificity and druggability

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE This proposal outlines a plan to understand the interactions between HIV-1 Gag protein, HIV-1 genomic RNA, and lipid membranes in the earliest stages of assembly of the HIV-1 capsid. Using a biochemically defined set of protein, RNA, and lipid components, we will use mass photometry to determine the distribution of complexes present. We will develop a specific mechanism for formation of the Gag nucleus for virus assembly at the membrane and packaging of the dimeric genomic RNA.

PI_NAMEs: WILLIAMSON, JAMES R (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Adsorption;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Body Weight Changes;Capsid;Cell membrane;Cell Nucleus;Cells;Complex;Coupled;Data;Diffusion;dimer;Dissociation;Equilibrium;equilibrium model;expectation;experimental study;gag Gene Products;genomic RNA;Guide RNA;HIV;HIV-1;In Vitro;innovation;Interferometry;Label;light scattering;Lipid Bilayers;Lipids;Literature;Measurement;Measures;Membrane;Membrane Lipids;Methods;Modeling;Molecular Weight;Monitor;monomer;myristoylation;novel;Pathway interactions;Phase;Photometry;Positioning Attribute;preference;Process;Proteins;recruit;Research;RNA;RNA Binding;Sampling;Scheme;Set protein;single molecule;Surface;System;Techniques;Thermodynamics;Time;viral genomics;Virus Assembly

PROJECT_TITLE: Initiation of HIV Capsid Assembly Monitored by Mass Photometry

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: In response to the need to prepare for emergence of drug resistant malaria parasites, several new antimalarials have recently been discovered that affect sodium homeostasis in malaria parasites. This project aims to understand the consequences of disrupting sodium and lipid homeostasis that lead to the killing of malaria parasites. This information would identify additional targets for antimalarial drug discovery by advancing our basic knowledge of malaria parasites.

PI_NAMEs: VAIDYA, AKHIL B (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Active Biological Transport;Affect;Anti-malarials;ATP phosphohydrolase;Biochemical;Biological;Biology;Carbon;Cell Cycle;Cell membrane;Cells;Chemicals;Cholesterol;Cholesterol Homeostasis;Chromosome Segregation;Clinical Trials;Collection;Complex;Cytolysis;Cytoplasm;Development;DNA metabolism;drug discovery;Drug resistance;Drug Targeting;Enzymes;Event;Exposure to;fatty acid transport;Fatty Acids;Funding;Genetic;genetic manipulation;Goals;Homeostasis;Homo;inhibitor;insight;interdisciplinary approach;Knowledge;lipid transport;Lipids;Malaria;Membrane;Metabolic;Metabolism;Molecular;Morphology;nuclear division;Parasites;Pathway interactions;Patients;Pediatric Hospitals;Pharmaceutical Preparations;Phase;Phenotype;Philadelphia;Physiology;Plasmodium;Plasmodium falciparum;Play;premature;prevent;Process;Protein Dephosphorylation;Protein phosphatase;Proteins;recruit;Research Personnel;response;rhoptry;Role;Signal Transduction;smoothened signaling pathway;Sodium;Structure;Universities;Work

PROJECT_TITLE: Molecular pathways affected by drugs that disrupt Na+ and lipid homeostasis in malaria parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Sleep Research;Social Determinants of Health

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE Stress can cause adaptive or maladaptive responses, the latter of which can lead to psychiatric disorders such as major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). It has been shown that (R,S)- ketamine is a stress resilience enhancer and specifically can buffer heightened fear expression, a core symptom observed in MDD and PTSD. Thus, this proposal aims to understand the neurochemistry underlying (R,S)-ketamine’s fear buffering effects using in vivo microdialysis and outlines a future postdoctoral direction in the field of stress resilience.

PI_NAMEs: MCGOWAN, JOSEPHINE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Affect;antagonist;anti-depressive agents;antidepressant effect;Anxiety;Attenuated;awake;Award;Behavior;Behavioral;Behavioral Assay;behavioral response;Biological;Buffers;career;comorbidity;Complement;conditioned fear;Data;Development;disability;Disease;early life adversity;Enhancers;experience;Exposure to;Female;foot;Fright;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Growth;High-Throughput RNA Sequencing;Hippocampus;Image;immune function;in vivo;in vivo imaging;Injections;insight;Institution;Ketamine;Knowledge;Laboratories;large scale data;Latina;Lead;Learning;Link;Long-Term Effects;Longitudinal Studies;Major Depressive Disorder;male;Measures;Mediating;Memory;Mental Depression;Mental disorders;Mentors;Microdialysis;Microscopy;Molecular;Mus;N-Methyl-D-Aspartate Receptors;neurochemistry;Neurons;Neurosciences;Neurotransmitters;novel;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiological;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Predisposition;prevent;promote resilience;Psychopathology;Reporting;Research;Research Personnel;Research Project Grants;resilience;response;Retrieval;Serotonin;Shock;Signal Transduction;skills;Sleep Architecture;Stimulus;Stress;stress disorder;stress resilience;stressor;Symptoms;Techniques;Testing;tool;Training;transcriptomics;treatment-resistant depression;Work

PROJECT_TITLE: Elucidating interactions among early life adversity, sleep architecture, and immune function


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: JACKSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Summary Benzodiazepines (BZs) are effective and safe for treating anxiety and sleep disorders when used appropriately, but their utility is limited by unwanted side effects like addiction and dangerous toxicity when combined with other drugs. The overall goal of this research is to use animal drug self-administration models to evaluate if prior experiences influence how BZs exert their effects. Our research will provide critical information for understanding how past and current drug use affects the abuse of BZ-type drugs, providing a novel approach to the development of improved BZ ligands.

PI_NAMEs: HUSKINSON, SALLY  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: abuse liability;addiction;Adult;Affect;Alprazolam;Animals;Anxiety Disorders;Attenuated;benzodiazepine abuse;benzodiazepine misuse;Benzodiazepines;Clinical Data;Cocaine;Dangerousness;Data;Development;Drug Modelings;drug of abuse;Drug usage;epidemiologic data;Exhibits;experience;experimental study;Exposure to;Food;GABA Modulators;General Population;Goals;Heroin;improved;Individual;Knowledge;Ligands;Macaca mulatta;Modeling;Monkeys;multiple drug use;non-drug;novel strategies;Opioid;Overdose;overdose death;Pattern;Pharmaceutical Preparations;pharmacologic;positive allosteric modulator;preclinical evaluation;predict clinical outcome;Procedures;programs;Psychological reinforcement;receptor;Recording of previous events;Reporting;Research;Risk;Role;Safety;Self Administration;side effect;Sleep Disorders;Stimulant;Substance Use Disorder;Testing;Therapeutic;therapeutic development;Toxic effect;Training

PROJECT_TITLE: Benzodiazepine Choice and Polydrug Use

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Dissemination and Implementation Research;HIV/AIDS;Mental Health

ORG_CITY: ABUJA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: INSTITUTE OF HUMAN VIROLOGY

PHR: PROJECT NARRATIVE The proposed Expanding the Pool of Independent Investigators in Implementation Science in Nigeria through HIV Research training (EXPAND Nigeria) project will focus on Reproductive, Maternal, Newborn, Child and Adolescent Health (RMNCAH) in the area of HIV and implementation research in Nigeria. We aim to develop a flexible, locally-tailored research curriculum incorporating hard and soft skill-building for postdoctoral early career investigators to attain research independence, and imparts program evaluation and knowledge translation skills to program implementers and policymakers, for high-level impact on RMNCAH gaps in Nigeria’s HIV program. EXPAND Nigeria’s scalable curriculum and mentoring approach address both independent research and programmatic capacity gaps, towards attaining sustainability for HIV research/research funding, and for high-level programmatic competencies.

PI_NAMEs: ABIMIKU, ALASH'LE G. (contact);SAM-AGUDU, NADIA A.

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Africa;Baltimore;career;Centers of Research Excellence;cohort;Collaborations;design;Doctor of Philosophy;Educational Curriculum;Epidemic;Funding;Health Priorities;HIV;Human;Hybrids;implementation science;Institution;International;knowledge translation;Leadership;Maryland;Mentors;Mission;multidisciplinary;Nigeria;Nigerian;Outcome;Persons;Policies;Policy Maker;Positioning Attribute;Productivity;Program Evaluation;programs;Public Health;Research;Research Personnel;Research Priority;Research Training;Scientist;skills;supportive environment;Training;Translating;Universities;virology;virtual

PROJECT_TITLE: Expanding the pool of Independent Investigators in Implementation Science in Nigeria throug h HIV research training (EXPAND)


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: IOWA CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because dissecting the downstream pathways of a key regulator of plasma lipoprotein metabolism is expected to increase our understanding of how lipid homeostasis is maintained and ultimately lead to improved methods of treating or preventing dyslipidemia and cardiovascular disease. Thus, the proposed research is relevant to the NIH's mission of pursuing fundamental knowledge that extends healthy life and reduces the burdens of illness.

PI_NAMEs: DAVIES, BRANDON SCOTT JOSEPH (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Alleles;ANGPTL3 gene;Antiatherogenic;ApoE knockout mouse;Apolipoprotein E;Atherosclerosis;Biochemical;Biological Assay;burden of illness;cardioprotection;Cardiovascular Diseases;cardiovascular health;Cardiovascular Pathology;Cause of Death;Cholesterol;Complex;Data;Deuterium;Disease;Disease Outcome;Dissection;Dyslipidemias;experimental study;Goals;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Homeostasis;Human;Hydrogen;Hydrolase;Hydrolysis;improved;improved outcome;inhibitor;innovation;Knowledge;Laboratories;Life;Lipase;LIPG gene;lipid metabolism;Lipids;lipoprotein lipase;Lipoproteins;Location;Mass Spectrum Analysis;Mediating;melting;Metabolic Diseases;Metabolism;Methods;Mission;Modeling;Mus;Mutagenesis;mutant;Pathologic;Pathway interactions;Phospholipase;Phospholipases A;Phospholipids;Physiological;Plasma;prevent;Proteins;Public Health;Radioactive Tracers;Regulation;Research;Role;Site-Directed Mutagenesis;Surface;Techniques;Temperature;Testing;Therapeutic;therapeutic target;Time;Tissues;Triglycerides;United States;United States National Institutes of Health

PROJECT_TITLE: Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL3

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE To colonize a host and cause disease, bacterial pathogens must rapidly respond to changes in the host environment to appropriately regulate gene expression. This application is designed to examine how the bacterial pathogen E. coli O157:H7 relies on RNA binding proteins to modulate gene expression and thereby enhance growth and pathogenesis. These studies may lead to the develop of novel therapeutics to treat infections.

PI_NAMEs: KENDALL, MELISSA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Ablation;Affect;Animal Model;Attenuated;Bacteria;Bacteria sigma factor KatF protein;Bacterial Genes;bacterial genetics;Biochemical;Biological Assay;Carbon;Cell Culture Techniques;Citrobacter rodentium;cold temperature;Colon;Complement;Consumption;cost;Cues;Defect;design;Diffusion;Disease;Enterobacteriaceae;Environment;Enzymes;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli EHEC;Escherichia coli O157:H7;Exhibits;experimental study;fitness;functional outcomes;Gene Expression;Gene Expression Regulation;Genetic;Genetic Epistasis;Genetic Transcription;Genomics;Gnotobiotic;Goals;Growth;gut colonization;helicase;Hemolytic-Uremic Syndrome;Hemorrhagic colitis;Human;Hyperplasia;Image;improved;In Vitro;in vivo;Infection;Inflammatory;Intestines;Invaded;Knowledge;Laboratories;Life;Location;member;Metabolic;Metabolism;model organism;Molecular;Molecular Target;Motility;mouse model;Mucous Membrane;Mus;mutant;Mutation;Nitrogen;novel therapeutics;Nutrient;Oxidation-Reduction;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Phagocytes;pharmacologic;Phenotype;Physiology;Play;Post-Transcriptional Regulation;Regulation;Respiration;response;RNA Helicase;RNA metabolism;RNA Stability;RNA-Binding Proteins;Role;Shock;Signal Transduction;spatiotemporal;Structure;Techniques;Temperature;Testing;Thinking;Tissues;trait;Transcript;transcription termination;transcriptomics;Translations;Type III Secretion System Pathway;Virulence;virulence gene;Work

PROJECT_TITLE: RNA-binding proteins in bacterial virulence and host-pathogen interactions

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative  Air pollution represents one of the largest public health burdens world-wide and is associated with increased risk of many neuropsychiatric disorders that are characterized by social dysfunction, including autism spectrum disorder (ASD). This project seeks to understand how prenatal exposure to a combination of air pollution and maternal stress (which unmasks vulnerability to environmental toxins) synergize to produce dysbiosis of the gut microbiome, and consequently, disruption of the neuro-immune mechanisms that regulate social behavior. The results of these experiments will answer outstanding questions about the relationship between the gut microbiome and the social brain and how this is impacted by environmental toxin exposure.

PI_NAMEs: SMITH, CAROLINE JACKSON (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adolescence;Affect;Air Pollution;Animal Model;autism spectrum disorder;Birth;Brain;brain cell;career development;Child;Communication;Data;deprivation;Development;Diesel Exhaust;Disease;Dissection;Dopamine;Dopamine D1 Receptor;dopamine system;Environmental Impact;Etiology;experimental study;Exposure to;Fostering;Foundations;Funding;Future;gastrointestinal symptom;Gene Expression;gut dysbiosis;gut microbiome;gut-brain axis;Human;Immune;Impairment;in vivo;Individual;individuals with autism spectrum disorder;Learning;Link;male;marginalized community;maternal microbiome;maternal stress;Mediating;metagenomic sequencing;Metagenomics;microbial;microbiome;Microglia;Modeling;Molecular;mouse model;neural circuit;neural network;Neuroimmune;Neuroimmunomodulation;neuropsychiatric disorder;novel;Nucleus Accumbens;offspring;optogenetics;particle;Partner in relationship;Pathway interactions;Patients;Phagocytosis;Phase;Physiology;Play;pollutant;postnatal;Pregnancy;prenatal;prenatal exposure;prevent;Psychosocial Stress;Public Health;Publishing;pup;receptor density;receptor expression;Reporting;Research;Resources;Rewards;Risk;Role;sex;Shapes;Shotguns;Signal Transduction;social;Social Behavior;Social Change;social deficits;Social Development;social disparities;Social Interaction;Source;Stress;stressor;Structure;Supplementation;Support System;synergism;Techniques;Testing;Toxic Environmental Substances;Training;transmission process;United States;Ventral Tegmental Area;Work

PROJECT_TITLE: Effects of air pollution/maternal stress on microglial sculpting of social circuits

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Congenital heart defects are present in 1-2 out of 100 births, and are the leading non-infectious cause of death in the first year of life. TBX5 mutations cause congenital heart defects, but it is not known how these mutations result in defective heart formation. We will use human cellular models and transgenic mice to understand the gene regulatory networks that TBX5 controls, to better understand congenital heart defects and perhaps their potential treatment.

PI_NAMEs: BRUNEAU, BENOIT GAETAN (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Adult;Alleles;ATAC-seq;Binding;Biology;Birth;candidate identification;Cardiac;Cardiac Myocytes;cardiogenesis;Cause of Death;cell behavior;Cell Line;Cell model;Cell Physiology;Cells;Chromatin;Congenital Abnormality;Congenital Heart Defects;Data;Data Set;Defect;Disease;DNA;dominant genetic mutation;dosage;Dose;Ensure;epigenomics;Event;experimental study;GATA4 gene;Gene Dosage;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;Genomics;Heart;Heart Atrium;heart defect;Heart Diseases;Heterozygote;histone modification;Holt Oram syndrome;Human;human induced pluripotent stem cells;in vivo;Individual;induced pluripotent stem cell;Infant Mortality;insight;Investigation;Label;Lead;Live Birth;loss of function mutation;Measures;Mediating;Modality;Modeling;Molecular;mouse model;Mus;Mutation;novel diagnostics;novel therapeutics;Phenotype;Population;progenitor;Regulation;Series;single cell ATAC-seq;single-cell RNA sequencing;SMARCA4 gene;stem cell model;System;Testing;Time;transcription factor;transcriptomics;Transgenic Mice;Translating;Ventricular Septal Defects;Ventricular septum;Work

PROJECT_TITLE: Gene regulatory networks for heart development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

PHR: A clear and specific clinical need motivates this proposal: improved and continuous understanding, monitoring, characterization, assessment and prediction of a prevalent neuro-cognitive condition in naturalistic settings. ADRDs are difficult and costly diseases to treat, affecting millions of people in the U.S alone. Our approach provides the foundation for a new direction in the early detection and prediction of this devastating and highly-debilitating condition.

PI_NAMEs: THOMAZ, EDISON  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Affect;Age;Alzheimer's disease related dementia;Behavior;Behavior assessment;Biological Markers;burden of illness;Cellular Phone;Clinic;Clinical;clinical practice;Cognitive;cognitive testing;Compensation;Computer Models;coping;Cost of Illness;Data;Data Collection;Detection;Devices;Digital biomarker;Disease;disease model;Disease Progression;Early Diagnosis;effective therapy;Epidemic;Ethnic Origin;Foundations;Health;Impaired cognition;improved;Instruction;Intervention;Machine Learning;Measures;Methods;mild cognitive impairment;Modeling;Monitor;multimodality;Neurocognitive;Neurologic;novel;Patients;Persons;Physicians;Population;Privacy;Race;Research;Research Technics;Risk Factors;Safety;sensor;Speech;Technology;Visit;Visual;wearable device

PROJECT_TITLE: SCH: Digital Biomarker and Analytics for Cognitive Impairment with Mobile and Wearable Sensing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE This study will determine the impact of autologous SCT with gene modified stem cells simultaneously targeting different stages of the HIV life cycle on the size and activity of the HIV reservoir, and determine if gene modified cells become infected with HIV following cessation of antiretroviral therapy. Results from this study will have the potential to improve and direct future gene therapy studies for HIV cure.

PI_NAMEs: HENRICH, TIMOTHY JENSEN (contact);MAVERAKIS, EMANUAL M.

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Affect;Aftercare;AIDS Malignancy Consortium;antiretroviral therapy;Autologous;Autologous Stem Cell Transplantation;Autologous Transplantation;Biological Assay;Blood;Capsid;CAR T cell therapy;CCR5 gene;CD34 gene;CD4 Positive T Lymphocytes;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;CXCR4 gene;Data;design;Disease remission;DNA;Engraftment;Enrollment;experience;Flow Cytometry;Future;Gene Expression;Gene Modified;gene product;gene therapy;Genes;Genetic Transcription;Hematologic Neoplasms;Hematopoietic stem cells;high dimensionality;HIV;HIV Infections;HIV resistance;HIV therapy;HIV-1;Human;Immune;immune reconstitution;Immunity;improved;In Vitro;in vivo;Individual;Infection;Infection prevention;Infusion procedures;innovation;insight;interest;Interruption;Knowledge;lentiviral integration;lentiviral-mediated;Lentivirus Vector;Life Cycle Stages;longitudinal analysis;Lymphocyte;Lymphoma;Macaca;Maintenance;Malignant Neoplasms;Measures;Mediating;Mutation;novel;Participant;Peripheral;Peripheral Blood Mononuclear Cell;Persons;phase 1 study;Population;prevent;primary endpoint;Protocols documentation;receptor;reconstitution;Recrudescences;Residual state;Resistance;Reverse Transcription;RNA;Safety;Sampling;Science;single-cell RNA sequencing;small hairpin RNA;stem cell gene therapy;Stem cell transplant;stem cells;stemness;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;Tissue Expansion;Tissues;Transactivation;Transduction Gene;Transplantation;Viral;viral entry inhibitor;Viral reservoir;Virus;Withdrawal

PROJECT_TITLE: HIV Reservoir and Gene Modified Cell Dynamics Following Autologous Stem Cell Transplantation

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The acquisition of new skills, including aural communication, can be facilitated when an observer is exposed to a conspecific performing a well-defined behavior (i.e., social learning). Since the neural bases for auditory social learning remain uncertain, this proposal will evaluate the idea that social cues induce experience- dependent plasticity in auditory cortex, thereby facilitating the acquisition of an acoustic task. The long-term impact of this research will be to test whether social experience can facilitate auditory learning in animals reared with developmental hearing loss, a condition that is associated with long-lasting aural communication deficits.

PI_NAMEs: SANES, DAN HARVEY (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Social learning enhances auditory cortex sensitivity and task acquisition

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Physical Injury - Accidents and Adverse Effects;Transplantation

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Immune suppression and impaired wound healing are drastic side effects of non-specific oral doses of anti- senescent drugs recently discovered to turn back the clock on aging and prevent many of the diseases of aging. Substantial evidence indicates controlled delivery timing by a biomaterial layer on a bone graft substitute will enable safe and effective dosing of anti-senescence drugs for bone healing in injured elderly patients. This grant will elucidate the effects of suppressing senescent cells on the interactions between the cells involved in bone repair in an aging bone model.

PI_NAMEs: KUHN, LIISA TIINA (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Acceleration;Address;Affect;Age;Aging;aging related disease;Anti-Inflammatory Agents;Antineoplastic Agents;Apoptosis;appropriate dose;Back;Benchmarking;Biocompatible Materials;Biological Assay;Biomimetics;BMP2 gene;bone;bone aging;Bone Density;bone healing;Bone Injury;bone repair;Bone Resorption;Bone Transplantation;calcium phosphate;Calvaria;cell age;Cell Culture Techniques;Cell Death;Cells;chemotherapy;Chronic;Communication;Conditioned Culture Media;cytokine;Data;Defect;Diabetes Mellitus;diabetic patient;Dose;Down-Regulation;Drug Delivery Systems;Drug Targeting;Drug toxicity;Elderly;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Equilibrium;Female;Future;Gene Expression;Goals;Grant;Growth Factor;healing;Health;Human;human subject;Immune response;Immune system;Immunohistochemistry;immunoregulation;Immunosuppression;Impaired wound healing;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;injured;Injury;Link;local drug delivery;Macrophage;Measures;Mediating;Metabolic Diseases;microCT;Minerals;Modeling;Mus;novel;obese patients;Obesity;old mice;older patient;Oral;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;osteoprogenitor cell;Parents;Pathway interactions;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;prevent;Proliferating;Recovery;recruit;regenerative;Rejuvenation;Reporting;Research;response;Role;scaffold;senescence;senescence associated secretory phenotype;senescent cell;senolytics;side effect;Signal Transduction;Subcutaneous Injections;Surface;Technology;Testing;Thinness;Time;transcriptome sequencing;translation to humans;Translations;Wild Type Mouse

PROJECT_TITLE: Modulated release of anti-senescence drugs to stimulate aged bone repair


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cancer;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This study is divided into two phases. Phase I is to complete PhD research investigating why aging in the peritoneal cavity enhances ovarian cancer metastatic success and reduces survival of aged women. Phase II is to conduct postdoctoral research in aging to determine how aging alters the immune system in ways that influence cancer progression and metastasis. Both phases include robust career development activities to ensure success of the proposed research and to establish a long-term career plan as an independent investigator who will evaluate the intersection of the aging immune system in cancers affecting women.

PI_NAMEs: HARPER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Abdomen;Adhesions;Adipocytes;Adipose tissue;Affect;Age;age effect;age related;age related changes;age related decline;aged;Aging;Allografting;American;animal old age;Antitumor Response;Area;Atomic Force Microscopy;Biomechanics;cancer cell;Cancer Patient;Carcinomatosis;career;career development;CD8B1 gene;Cell Transplantation;Cells;Cessation of life;Chemicals;Chronic;cohort;Collagen;Collagen Type I;Complex;crosslink;Cytometry;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;Differential Scanning Calorimetry;Disease;Disseminated Malignant Neoplasm;Distant;Doctor of Philosophy;Elasticity;Ensure;Environment;experimental study;fighting;Generations;Goals;Greater sac of peritoneum;high risk;Home;Immune;immune cell infiltrate;immune function;Immune system;immunosenescence;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;Infection;Infiltration;Inflammation;Integration Host Factors;intercalation;intraperitoneal;Invaded;juvenile animal;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of abdomen;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;Membrane;Mesothelial Cell;Microscopy;Modification;monolayer;mortality risk;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;old mice;older women;Omentum;Organ;Ovarian aging;Ovary;Patients;Peritoneal;Peritoneal Mesothelial Cell;Peritoneum;Phase;Population;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;pre-doctoral;Predisposition;Primary Neoplasm;Principal Investigator;Prognosis;prognostic tool;Proliferating;Proteome;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Research Project Grants;Research Training;response;Risk Factors;Role;Scanning Electron Microscopy;second harmonic;Secondary Lesion;Series;Site;Skin;small molecule;Structure;success;Surface;Survival Rate;T cell infiltration;T-Lymphocyte;tandem mass spectrometry;Tissues;Training;Translational Research;Transplantation;trend;tumor;Tumor Burden;tumor immunology;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;Visceral;Woman;women's diagnosis

PROJECT_TITLE: Integrative Analysis of the Aging Peritoneum in Metastatic Receptivity


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Depression;Genetics;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

PHR: The proposed research is relevant to the public health mission of the NIH because it will address significant gaps in understanding the genetic risk architecture of postpartum psychosis. Elucidation of the genetic risk profile of postpartum psychosis will give researchers insight whether its etiology is different from bipolar disorder or not, which will help with diagnostic classification. In addition, this proposal provides clinical useful information for pregnant women with first-degree family members with severe mental illness as it will inform them on their risk profile after delivery.

PI_NAMEs: MAHJANI, BEHRANG  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;Age;age effect;Architecture;Area;Bipolar Disorder;bipolar psychosis;bipolar spectrum;Birth;Childbirth;Classification;Clinical;cohort;Computing Methodologies;Data;design;Diagnosis;Diagnostic;Disease;disease classification;Environment;Environmental Risk Factor;epidemiologic data;Etiology;Family;Family history of;Family member;Family Relationship;First Degree Relative;General Population;Generations;Genetic;Genetic Diseases;genetic pedigree;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Goals;Heritability;high risk;Infanticide;innovation;insight;Intercept;Interview;Link;Manic;Maternal Age;Measures;Medical emergency;Mental Depression;Mental disorders;Methods;Mission;Modeling;Mood Disorders;mood symptom;Mothers;Neurobehavioral Manifestations;Neurobiology;novel;Orphan;Outcome;Parents;Phenotype;Population;population based;Positioning Attribute;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;Prevalence;Prevention Guidelines;proband;prognostic;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Public Health;Quantitative Genetics;Rare Diseases;Recording of previous events;Recurrence;Registries;Relative Risks;Research;Research Personnel;Resources;Risk;Risk Estimate;Risk Factors;risk sharing;Schizophrenia;Selection Bias;severe mental illness;Siblings;Socioeconomic Factors;Source;Statistical Methods;suicidal risk;Survival Analysis;Sweden;System;Time;treatment guidelines;United States National Institutes of Health

PROJECT_TITLE: Risk architecture of postpartum psychosis

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Aging;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Aging in humans leads to a chronic inflammatory state, known as inflammaging, which increases the risk for age-related diseases such as type 2 diabetes, atherosclerosis, and Alzheimer's disease. This proposal applies novel approaches to identify a potential molecular mechanism of inflammaging and the associated impairment in blood cell differentiation, while illuminating the physiological roles of protein self-assemblies in innate immune signaling. The insights that emerge from this research will advance our understanding of aging from a fundamental molecular perspective and potentially illuminate new opportunities to combat age- and disease-associated autoinflammation.

PI_NAMEs: RODRIGUEZ GAMA, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Acute;Address;Age;age-related disease;aged;Aging;Alzheimer's Disease;Atherosclerosis;autoinflammation;autoinflammatory diseases;Biochemical;Biological Assay;Biophysics;Blood Cells;Cell Culture Techniques;Cell Death;Cell Differentiation process;Cell Line;Cells;Chronic;combat;cytokine;Cytology;Data;Death Domain;digital;Disease;Elderly;Event;exhaustion;experimental study;Family;Family member;fitness;gene-editing approach;Goals;Hematopoiesis;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeostasis;Human;human induced pluripotent stem cells;Immune;Immune signaling;Immunologic Memory;immunosenescence;Impairment;In Vitro;in vivo;in vivo Model;Infection;Inflammaging;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innate immune function;Innate Immune System;innovation;insight;Lead;Ligands;Measures;member;Molecular;monocyte;mortality;mortality risk;Myeloid Cells;Myelopoiesis;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Organism;Parkinson Disease;particle;pathogen;pathogen exposure;Pathogenesis;pathogenic fungus;Pathologic;Pattern recognition receptor;Phase;Phase Transition;Phenotype;Physiological;polymerization;Polymers;post-doctoral training;Postdoctoral Fellow;prevent;prion-like;Prions;Process;Production;programs;Property;protein complex;protein function;Proteins;receptor;Receptor Activation;Reporter;Research;Research Personnel;Research Project Grants;response;Risk;Role;self assembly;self-renewal;senescence;Signal Pathway;Signal Transduction;stem cell exhaustion;Stimulus;Tertiary Protein Structure;tool;Work

PROJECT_TITLE: Evaluating the role of protein self-assembly in the innate immune system


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PUBLIC HEALTH RELEVANCE Understanding the mechanism of action of the SSB interactome is important to public health as the interactome is an OB-fold family of genome guardians and defects in these families in higher organisms lead to the accumulation of mutations leading to cancer. The proposed research is relevant to the part of NIH's mission that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: BIANCO, PIERO R (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affinity;Binding;Binding Proteins;Biochemistry;Biological Assay;Biological Models;Biology;BRCA2 gene;C-terminal binding protein;Caring;Cell Death;combinatorial;Complex;Creativeness;Cryoelectron Microscopy;Crystallography;Data;Defect;Development;Disparate;DNA;DNA Binding;DNA biosynthesis;DNA metabolism;DNA-Binding Proteins;DNA-Directed DNA Polymerase;Elements;Enzyme Kinetics;Escherichia coli;Eukaryota;Event;Family;Family member;Fostering;Genetic;Genetic Recombination;Genome;genome integrity;Genome Stability;Goals;Health;helicase;human disease;improved;In Vitro;in vivo;innovation;insight;Kinetics;Lead;Length;Maintenance;Malignant Neoplasms;Mediating;member;Mission;Molecular;Multiple Partners;Mutation;novel;Oligonucleotides;Oligosaccharides;Organism;Outcome;Play;Prokaryotic Cells;protein B;protein function;Proteins;Public Health;public health relevance;Publishing;Reaction;repaired;Replication-Associated Process;Research;Role;single molecule;Single-Stranded DNA;SS DNA BP;Structure;superresolution microscopy;System;Tail;Testing;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Insight into the mechanism of action of the SSB interactome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Rehabilitation;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Hoarding disorder (HD) is a chronic, progressive, and debilitating psychiatric condition that leads to devastating personal and public consequences, particularly for older adults. This confirmatory efficacy trial will advance our knowledge of the mechanisms of action in the treatment of HD as well as reduce symptom severity, disability, and community consequences.

PI_NAMEs: AYERS, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: active lifestyle;Acute;Address;Adult;Aftercare;Age;Anxiety;anxiety reduction;Area;Behavioral;Behavioral Sciences;Case Management;Chronic;Clinical;clinically significant;Clutterings;Cognitive;cognitive control;cognitive process;cognitive rehabilitation;Communities;Compulsive Hoarding;confirmatory trial;Dangerousness;Decision Making;Dementia;Demographic Factors;disability;Disease;Distress;Economics;effective therapy;effectiveness trial;Elderly;Epidemiology;Evaluation;executive function;fall risk;Family;Fire - disasters;follow-up;Fright;Functional impairment;functional improvement;functional outcomes;geriatric mental health;Goals;Healthcare Systems;Home;Homelessness;improved;Individual;Individual Differences;Intervention;Knowledge;late life;Lead;Left;Life;Maintenance;maladaptive behavior;Mediating;Mental Depression;middle age;National Institute of Mental Health;neuropsychiatry;Office Visits;older adult;Outcome;Participant;Patient Self-Report;Pharmaceutical Preparations;Physiological;Population;Prevalence;prevent;primary outcome;Public Health;Randomized, Controlled Trials;Recovery;reduce symptoms;Reporting;Research Domain Criteria;response;secondary outcome;Severities;social;Social isolation;Sorting;Symptoms;System;Therapeutic;therapy development;Treatment Factor;Treatment outcome;Update

PROJECT_TITLE: Cognitive Rehabilitation and Exposure Therapy for Geriatric Hoarding


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Food insecurity is a significant public health concern, impacting nearly 16% of U.S. households with children, but its effects on child growth and developmental trajectories are not well documented. To better understand the impact of food insecurity on child growth and development, I propose utilizing data from two ongoing birth cohort studies to assess the effects of intermittent and persistent early life food insecurity on 1) maternal obesity and cognitive function, and 2) childhood growth and cognitive development trajectories from early childhood to age 18. This K99/R00 project will combine targeted career development, training and mentorship and cutting edge epidemiologic research using body composition measurement and cognitive assessment methods, that will provide novel insights to inform evidence-based recommendations and interventions to support heathy growth trajectories and cognitive development in children.

PI_NAMEs: KINSEY, ELIZA W. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: abdominal fat;active lifestyle;Adolescence;Adolescent;Adolescent obesity;Adult women;Age;Anxiety;Attention;Award;Birth;Body Composition;Body mass index;Brain;career;career development;Child;Child Rearing;Childhood;Cognition;Cognitive;cognitive control;cognitive development;cognitive function;cognitive load;cognitive testing;cohort;Cohort Studies;Collection;community partnership;Complex;Data;Data Analyses;Data Collection;design;Development;diagnostic screening;Diagnostic tests;early childhood;Emotional;Enrollment;Environment;Environmental Health;Epidemiologic Methods;Epidemiology;epidemiology study;evidence based guidelines;experience;Family;follow-up;Food;Food Assistance Programs;food insecurity;food marketing;food security;Generations;Goals;Growth;Growth and Development function;Health Food;health of the mother;Health Policy;Health Status;healthy lifestyle;Household;indexing;insight;Intervention;Knowledge;Life;Link;Liquid substance;Long-Term Effects;Longitudinal cohort study;Low income;Magnetic Resonance Imaging;maternal obesity;Measurement;Measures;Mentorship;Methods;middle childhood;Mothers;Motor;Newborn Infant;novel;nutrition;Obesity;obesity development;obesity in children;Pathway interactions;Phase;Policies;postnatal;Pregnancy;prenatal;Psyche structure;psychosocial;Public Health;Public Health Schools;Research;Role;Scientist;Screening procedure;skills;Social Policies;Special Supplemental Nutrition Program for Women, Infants, and Children;Stress;Supervision;Surveys;System;Teenagers;Testing;Time;Training;Translations;Urban Health;Woman;Work;young adult;Youth

PROJECT_TITLE: Impacts of Early Life Food Insecurity on Child Obesity and Cognitive Development Trajectories