NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The cross-species emergence of SARS-CoV-2 from wild, Rhinolophus spp. bats to human hosts highlights the extreme public health, economic, and societal consequences that can result from zoonotic spillover. This proposal leverages tools from mathematical modeling, field biology, and molecular immunology to decipher the mechanisms underpinning the circulation of bat-borne viruses at a population-level, understand the processes which shape their pathology within-host, and eradicate them from reservoir populations to prevent future threats of zoonotic emergence.

PI_NAMEs: BROOK, CARA  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Anti-Inflammatory Agents;bat-borne;betacoronavirus;Biology;Cell Line;Chiroptera;Circulation;Communities;Consumption;Coronavirus;COVID-19 pandemic effects;cross-species transmission;Data;Disease;Disparate;Ebola;Economics;Ecosystem;Exhibits;exposed human population;Exposure to;Filovirus;Food;Fruit;Future;Hendra Virus;Henipavirus;Human;Immune system;Immunologics;Infection;interest;Island;Laboratories;Madagascar;Mammals;Marburgvirus;mathematical model;Middle East Respiratory Syndrome;Modeling;Molecular;Molecular Immunology;Nipah Virus;Nutritional;pathogen;Pathology;Physiologic pulse;Physiological;Population;Population Study;prevent;Prevention;Process;Public Health;reproductive;Research;Sampling;Seasons;Series;Serology;Severe Acute Respiratory Syndrome;Shapes;Source;spillover event;Stress;System;Testing;therapy design;Time;tool;transmission process;Vaccines;Viral;Virulent;Virus;Virus Shedding;Zoonoses;zoonotic spillover

PROJECT_TITLE: Crossing scales to predict and prevent bat virus zoonoses in a Madagascar ecosystem


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: College Station

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: RNA silencing regulates essentially every biological process in eukaryotes, and their dysregulations causes numerous diseases and physiological disorders in human and in plants. The proposed study is to determine how several newly identified components such as RNA helicases, catalases, U1-70K, and BICE1 contribute to the production of small RNAs for RNA silencing in Arabidopsis. The studies on the new regulatory mechanisms in RNA silencing in the model organism Arabidopsis may enable us to manipulate these components for a better therapeutic strategy to cure physiological disorders that arise from dysfunctions of RNA processing in biotechnology.

PI_NAMEs: ZHANG, XIUREN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Arabidopsis;Area;Binding Proteins;Biogenesis;Biological Process;Biology;Biotechnology;catalase;Cell Nucleus;Chromatin;Complex;Cytoplasm;Data;Disease;DNA-Directed RNA Polymerase;Double-Stranded RNA;Eukaryota;Functional disorder;Gene Silencing;Genetic Screening;Goals;Human;Laboratories;Mediating;Microprocessor;MicroRNAs;model organism;novel;parent project;Pathway interactions;Physiological;Plants;Process;Production;Proteins;Reactive Oxygen Species;Regulation;Research;Ribosomes;RNA;RNA Helicase;RNA Interference;RNA Processing;RNA-Directed RNA Polymerase;sensor;Small Interfering RNA;Small RNA;Specific qualifier value;Structure;Suppressor Genes;Therapeutic;Transcript

PROJECT_TITLE: Functions and mechanisms of new components in RNA silencing--Admin Supp


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Precision Medicine

ORG_CITY: BURLINGAME

ORG_NAME: COLOR HEALTH, INC.

ORG_STATE: CA

PHR: The program will have an immediate impact on public health through the provision of direct clinical services to All of Us participants, in the form of clinical genetic testing and genetic counseling for adult-onset hereditary diseases.

PI_NAMEs: TOPPER, SCOTT  (contact)

PROGRAM_OFFICER_NAME: MOORE, RHONDA JUANITA

PROJECT_TERMS: Acceleration;Address;All of Us Research Program;Ancillary Study;Appointment;Architecture;Area;Automobile Driving;base;Caring;Clinical Services;cohort;Color;Communication;Computer software;Consultations;cultural competence;Custom;Data;Data Collection;design;Diagnostic tests;Electronic Mail;Elements;Empathy;Enrollment;Ensure;Ethics;experience;Future;Generations;Genetic Counseling;genomic platform;Genomics;Geography;Goals;Health;Health Professional;improved;individualized prevention;Infrastructure;insight;Institutional Review Boards;Intuition;life span;Medical;meetings;Mission;Multilingualism;Notification;Participant;Patient Care;patient engagement;Pharmaceutical Preparations;Phase;Population;population health;Privacy;programs;recruit;Reporting;Research;Resources;Secure;Security Measures;service delivery;Services;software development;software infrastructure;Software Tools;success;Telephone;Time;tool;web based software;Work

PROJECT_TITLE: Color's software and services platform for the Return of Personalized Value to the All of Us Research Program participants


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NOT APPLICABLE - Please refer to original proposal.

PI_NAMEs: OIKONOMOU, EVANGELOS  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Hypertrophic Cardiomyopathy;multimodality;point of care;screening

PROJECT_TITLE: A multi-modal approach for efficient, point-of-care screening of hypertrophic cardiomyopathy


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The proposed research will apply transcutaneous vagus nerve stimulation, a non-invasive brain stimulation method that modulates a system in the brain that is initially affected by Alzheimer's disease pathology and enhances memory performance, and thus may hold the key to successfully delay this disease in its earliest stages. We will assess the duration and extent of improvements in cognitive performance, and will identify individual, brain physiology and Alzheimer's disease-related factors that contribute to its success in older individuals without clinical impairment, including those at risk for Alzheimer's disease. This project has important public health implications as it gathers critical information to identify the target population, and to inform designs of future clinical trials aimed at prevention of Alzheimer's disease.

PI_NAMEs: JACOBS, HEIDI IRMA (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Affect;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Animals;apolipoprotein E-4;Biological;Biological Markers;Blood specimen;blood-based biomarker;Brain;Brain Stem;Cell Nucleus;Characteristics;Clinical;Clinical Trials;Cognitive;cognitive performance;cognitive testing;Crossover Design;demographics;design;Disease;Disease Progression;Double-Blind Method;Eligibility Determination;Enrollment;follow-up;Future;Goals;Image;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;locus ceruleus structure;Measures;Memory;Methods;Monitor;Nerve;neurophysiology;noninvasive brain stimulation;Norepinephrine;Older Population;Outcome;Outcome Measure;Pathology;Pathway interactions;Patients;Performance;Phase;Physiology;Population;predictive marker;preventive intervention;Property;Public Health;Randomized;randomized, clinical trials;Research;Research Personnel;response;Risk;Series;Site;Stratification;success;System;Target Populations;Time;vagus nerve stimulation

PROJECT_TITLE: The wandering nerve: gateway to boost Alzheimer's disease related cognitive performance

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: HUNGRY HEART MEDIA, INC.

PI_NAMEs: BRINKOETTER, APRIL  (contact)

PROGRAM_OFFICER_NAME: GARCIA-QUIJANO, NICOLE ALEXANDRA

PROJECT_TERMS: All of Us Research Program;Biomedical Research;biomedical resource;Child;citizen science;cohort;Communication;Communities;community college;Consent;Data Set;design;Development;digital tool;Enrollment;Ensure;experience;falls;Foundations;Future;Goals;Health;ideation;improved;Individual;insight;Institution;Intuition;Marketing;member;Parents;Participant;Pathway interactions;Persons;Pilot Projects;Process;programs;Research;Research Design;Research Methodology;Research Personnel;Time;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: Experience Design, Communications and Marketing for the All of Us Research Program


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Despite the availability of guidelines for cancer survivorship, including the newly released National Standards for Cancer Survivorship Care, receipt and overall quality of survivorship care is inconsistent across survivors and treating facilities, with gaps in our knowledge of best practices for delivering tailored survivorship care to meet the unique needs of adolescent and young adult (AYAs) cancer survivors. Within this proposal, our team will conduct a mixed-methods study of AYA cancer survivors (ages 15-39 years at diagnosis) diagnosed between 2014-2019, using cancer registry data linked with electronic health record (EHR) data and patient surveys, and supplemented by focus groups and key informant interviews with stakeholders. Our primary goal is to understand the current landscape of how national survivorship care standards are implemented, to identify barriers driving underutilization of AYA survivorship care, and to develop priorities for enhanced survivorship care that directly address patient-driven approaches for reducing these barriers.

PI_NAMEs: YEE, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Age;age group;Area;Automobile Driving;Biometry;Cancer Center;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer survivorship care;Cardiovascular Diseases;care delivery;Caring;Catchment Area;Cessation of life;Characteristics;Childhood;Clinical;clinical infrastructure;Collaborations;Coupled;Data;data registry;Data Reporting;design;Development;Diagnosis;Disparity;Early Diagnosis;Education;Electronic Health Record;Equity;experience;Focus Groups;follow-up;Future;Geography;Goals;Growth;Guidelines;Health;Health behavior;health disparity;Health Services Research;Health system;improved;Incidence;informant;Infrastructure;interest;Intervention;Interview;Knowledge;Late Effects;Life;life span;Link;Malignant Neoplasms;Methods;Minnesota;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;neoplasm registry;Non-accidental;novel;Oncology;Patients;Population;Positioning Attribute;Primary Care;primary outcome;Provider;Psychosocial Assessment and Care;Quality of Care;Quality of life;Recording of previous events;Research;response;Risk;Risk Factors;Risk Reduction;screening;sociodemographics;Standardization;Stroke;Supportive care;Surveys;Survivors;survivorship;United States Department of Veterans Affairs;Universities;Visit;Work

PROJECT_TITLE: Assessing and Enhancing Survivorship Care in Adolescent and Young Adult Cancer Survivors


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The last step in cell division, abscission, relies on a transient structure called the midbody, which resides inside the intercellular bridge between newly forming daughter cells. It consists of overlapping spindle midzone microtubules which are coated with electron dense material called the midbody matrix. Long conceptualized as a structural remnant subject to degradation following cytokinesis, emerging data suggest that midbody remnants (MBsomes) play instructive post-mitotic roles in establishing cell fate, proliferation state, tissue polarity, cilia formation, neuron function, and oncogenesis. However, very little is known about the functional significance of the electron dense material. My lab has uncovered a surprising novel function for this electron dense material in that it is a site of RNA storage and is a novel actively translating RNP granule with a uniquely complex life cycle comprised of both membrane-less and membrane-bound phases, that we are calling the MB-granule (for Midbody-granule). Our current research goals are to understand how the midbody behaves as a novel form of intercellular communication, to define distinct therapeutic targets for midbody-mediated human diseases that range from cancer to neurodegeneration.

PI_NAMEs: SKOP, AHNA RENEE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Active Sites;Address;Affect;Anaphase;Aneuploidy;Architecture;Binding;Biogenesis;Biological Assay;Biological Response Modifier Therapy;biophysical properties;Cell division;cell fixing;cell type;Cells;Characteristics;Chemistry;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Color;common treatment;Complex;Coupled;Cytokinesis;Cytoplasm;Cytoplasmic Granules;Data;daughter cell;delivery vehicle;Disease;Double-Stranded RNA;Electrons;Embryo;Excision;Exhibits;extracellular;extracellular vesicles;genetic manipulation;Genomics;Goals;Hela Cells;Human;human disease;innovation;insight;intercellular communication;Kinesin;Knock-out;Life Cycle Stages;LOX gene;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Microcephaly;Microtubules;Mitosis;Mitotic;Modeling;Molecular;Motor;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear Envelope;Oncogenic;Organelles;Phase;Physical condensation;Play;pluripotency;postmitotic;Proliferating;Proteins;Publishing;Regulation;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Ribonucleoproteins;RNA;RNA Transport;Role;scaffold;Signal Transduction;Site;spatiotemporal;stem cells;Structure;Syndrome;System;therapeutic target;Tissues;Transcript;transcription factor;transcriptome sequencing;transcriptomic profiling;Translating;Translation Initiation;Translations;tumorigenesis;ultra high resolution;Work

PROJECT_TITLE: Functional analysis of mammalian midbody RNA in post-mitotic signaling functions

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PHR: OVERALL PROJECT NARRATIVE Yale Cancer Center (YCC) is committed to eliminating the burden of cancer through transformative research, with attention to the needs of all people facing this disease. Our goal is to understand and prevent cancer, detect cancer early, and manage cancer more effectively, while maximizing access to care, addressing the needs of the community, ensuring equity and diversity in our workplace, and training future cancer researchers, clinicians, and leaders.

PI_NAMEs: WINER, ERIC P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academia;Address;anti-cancer research;Area;Attention;Award;Back;Basic Cancer Research;Basic Science;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer therapy;career development;Caring;Catchment Area;Clinic;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collaborations;combat;Communities;community involvement;Connecticut;design;Diagnosis;Direct Costs;Disease;Disparity;Disparity in diagnosis;disparity reduction;Diverse Workforce;diversity and equity;Dreams;Ensure;Equity;Fostering;Funding;Future;Goals;Grant;Health Services Accessibility;Heart;Improve Access;improved;Individual;Industry;innovation;Institution;Investments;Journals;Knowledge;Laboratories;Leadership;Link;Malignant Neoplasms;member;Mentors;NCI Center for Cancer Research;next generation;novel;novel therapeutic intervention;Outcome;Output;Patient Selection;Patients;Peer Review;Persons;Physicians;Population;Population Sciences;prevent;programs;Publications;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Screening for cancer;Services;Source;Strategic Planning;synergism;Technology;therapy resistant;Training;Training and Education;Translating;Translational Research;Universities;Vision;Work;Workplace;Yale Cancer Center

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project narrative  Textural aspects of food, termed mouthfeel, are important flavor qualities that can determine whether food is eaten or discarded, and thus, are essential factors for dietary health. Currently, little is known about the basic neuronal mechanisms underlying mouthfeel or the processes by which this flavor modality modifies taste. This work provides a comprehensive identification of mammalian mechanosensory neurons of the tongue and identifies mechanotransduction channels that underlie mouthfeel, with the long-term goal of understanding how mechanosensation impacts flavor perception.

PI_NAMEs: MOAYEDI-ESFAHANI, YALDA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Affect;Afferent Neurons;Anatomy;Astringents;Auditory;Basic Science;Behavioral;Biology;calcium indicator;Cells;Central Nervous System;Complement;conditional knockout;Consumption;Cre driver;Cues;Data;Deafferentation procedure;Dietary Factors;Dietary intake;Eating;Energy Intake;Esthesia;Family;feeding;Filiform Papilla;Food;food consumption;Food Preferences;food quality;Foundations;Fungiform Papilla;Future;Ganglia;Goals;Health;hedonic;Histology;Human;imaging study;in vivo calcium imaging;Intake;Ion Channel;Ion Channel Gating;Knockout Mice;Knowledge;Label;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;mechanotransduction;Methods;Modality;Molecular;molecular marker;Morphology;multisensory;Mus;nerve supply;Nervous System;Neuroanatomy;Neurons;Nutrient;Nutritional;Oral;Oral cavity;Organ;Perception;Peripheral;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Population;pressure;Process;programs;Property;Publishing;Reporter;Research;response;Role;Sensory;Signal Transduction;SLC17A8 gene;Smell Perception;somatosensory;somesthesis;Stimulus;Structure of trigeminal ganglion;Surveys;Tactile;Taste Perception;Technology;Testing;Texture;Tongue;tongue papilla;tool;Touch sensation;Transgenic Mice;Transgenic Organisms;Trigeminal System;Viscosity;Visual;Work

PROJECT_TITLE: Mechanosensory substrates of flavor in the mammalian tongue

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Facial disfigurement due to the loss of soft tissue is debilitating, and current therapies are limited because of tissue rejection and lack of suitable tissue. We propose to bioengineer craniofacial muscle tissue by using the subject’s own cells combined with innovative 3-D printing technologies and specialized bioreactors. This research has potential to advance our knowledge of muscle engineering applications, and develop novel and precise therapies to manage volumetric muscle tissue loss of the craniofacial region.

PI_NAMEs: SHAH, RISHMA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;3D Print;Address;American;Appearance;Area;Autologous;barium chloride;Beauty;Biological Models;Biomedical Engineering;Biomimetics;Bioreactors;Bone Tissue;cell behavior;Cell Differentiation process;Cell Proliferation;Cells;Characteristics;Cheek structure;Climacteric;Cosmetics;craniofacial;Craniofacial Abnormalities;craniofacial tissue;Defect;Development;Elements;Engineering;expectation;Extracellular Matrix;Face;facial disfigurement;Failure;Family suidae;Fatty acid glycerol esters;Fiber;Filler;Financial Hardship;GDF8 gene;Goals;Growth Factor;Healthcare;Human;Human body;Hypertrophy;Implant;implantation;improved;In Vitro;in vivo;Individual;Injury;innovation;Insulin Antagonists;Insulin-Like Growth Factor I;Knowledge;Masseter Muscle;mechanical load;mechanical properties;Mechanical Stimulation;Metabolic;Morphology;Mus;Muscle;Muscle Cells;Muscle Development;muscle engineering;Muscle Fibers;muscle form;muscle progenitor cell;muscle regeneration;Muscle satellite cell;muscular structure;Natural regeneration;novel;Outcome;patient subsets;Patients;personalized approach;Population;porcine model;postnatal;Procedures;Proliferating;Property;quadriceps muscle;Quality of life;regenerative;repaired;Research;Resources;response;restoration;scaffold;Skeletal Muscle;Societies;soft tissue;stemness;subcutaneous;Supplementation;Surgeon;Technology;Testing;Tissue constructs;Tissue Engineering;tissue reconstruction;Tissues;translational model;Vision;Work

PROJECT_TITLE: Skeletal Muscle Engineering for the Craniofacial Region


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  While there is a growing body of evidence suggesting that music training benefits brain development, the evidence is not conclusive and rigorously designed RCT neuroimaging studies are needed to provide a definitive answer to whether and which brain circuits are enhanced by music training and how. The scientific goal of this project is to study the effects of a community-based music training program on neurodevelopment among Hispanic children from low-income communities. Implementing cost-effective, community-focused sustainable, and novel strategies for ethnic minority children will help offset the burden associated with negative health outcomes such as obesity.

PI_NAMEs: HABIBI, ASSAL  (contact);LUO, SHAN

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Address;Adherence;Adult;Affective;after-school program;Age;Anterior;Auditory;Behavior;behavior change;behavior measurement;Behavioral;Books;Brain;brain circuitry;Child;cingulate cortex;Clinical;cognitive function;cohort;Communities;community involvement;Complex;computerized;Control Groups;Correlation Studies;cost effective;Cultural Diversity;design;Development;early adolescence;ethnic minority;Ethnic Origin;Exhibits;Feasibility Studies;feasibility testing;Focus Groups;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Health;high risk;Hispanic;Home environment;Image;improved;Individual;Intervention;Intervention Studies;Intervention Trial;Investigation;Life;Low income;Measurement;Measures;middle childhood;minority children;Motivation;Motor;Motor Cortex;Motor Skills;Multimodal Imaging;Music;musician;neural recruitment;neurodevelopment;neuroimaging;Neuronal Plasticity;novel strategies;Obesity;Outcome;Outcome Study;Participant;Phase;Play;Population;Prefrontal Cortex;primary endpoint;primary outcome;Process;programs;Prospective Studies;Randomized;Randomized, Controlled Trials;recruit;Regulation;Reporting;Research Personnel;response;retention rate;Rewards;Role;Sampling;Schools;secondary outcome;Selection Bias;sensory system;Services;Signal Transduction;Societies;Socioeconomic Status;somatosensory;Structure;Students;success;System;Testing;Time;timeline;Training;Training Programs;trial design;underserved community;Visual System;Work;Youth

PROJECT_TITLE: Effects of Music Training on Neurodevelopment and Associated Health Outcomes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Altered trajectories of amygdala development are highly linked to a host of mental health disorders, such as autism spectrum disorder (ASD) and the long term consequences of early life stress. Using the mouse as a model, the goal of our proposed studies is to understand the dynamic changes in circuit connectivity, neuronal responsivity and behavioral function of a novel population of amygdala neurons that mature coincident with adolescence.

PI_NAMEs: CORBIN, JOSHUA G (contact);SORRELLS, SHAWN

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Adolescence;Amygdaloid structure;Anatomy;ARHGEF5 gene;Association Learning;autism spectrum disorder;Behavior;behavior test;Behavioral;Biological;Brain;CASP3 gene;Cell Nucleus;critical period;Cues;Data;designer receptors exclusively activated by designer drugs;Development;Discrimination Learning;early adolescence;early life stress;Embryo;emerging adult;Emotional;emotional behavior;excitatory neuron;Fiber;FOS gene;Functional disorder;Goals;habituation;Human;in vivo;Life;Link;Maps;Mental disorders;Modeling;Motivation;Mus;Neurons;novel;olfactory nuclei;Pattern;Photometry;Play;Population;Positioning Attribute;postnatal development;Publishing;response;Role;Sensory;social;social cognition;social deficits;social emotional learning;social learning;Structure;Synapses;Testing;Time;transition to adulthood;unpublished works;Viral;Work

PROJECT_TITLE: Functional maturation of amygdala circuitry during adolescence

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Global Health Equity Scholars Program - Navarro-Galarza

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Vision in mosquitoes plays a critical but understudied role in their attraction to hosts. This project will determine the visual features (colors, size, motion) that mosquitoes find attractive and characterize how odor modulates visual responses. This work will also test new visual lures and identify potential molecular targets that compromise the visual and olfactory behaviors to hosts.

PI_NAMEs: AKBARI, OMAR SULTAN;RIFFELL, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Anopheles Genus;Area;base;Behavior;Behavioral;Behavioral Assay;Biogenic Amine Receptors;Biological Assay;Bite;Blood;Brain;Calcium;Carbon Dioxide;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Color;Color Visions;combat;Coupling;Cues;Culex (Genus);Culicidae;Darkness;Dengue;design;Detection;Development;Disease;Disease Vectors;Environmental Wind;experimental study;Eye;Flying body movement;food resource;Future;Gene Targeting;Generations;Genetic;genetic approach;Genome engineering;Goals;Human;Image;Insect Vectors;Insecta;insight;Intervention;Knock-out;Link;Malaria;Mediating;Methods;Modality;Molecular Genetics;Molecular Target;Mosquito Control;Motion;mutant;Mutate;neural;neuromechanism;Neuromodulator;Neurons;neurophysiology;neuroregulation;novel;Octopamine;octopamine receptor;Odors;Opsin;Optic Lobe;Oranges;Paper;Partner in relationship;pathogen;Photoreceptors;Play;preference;Process;Publishing;receptor;response;Rhodopsin;Role;Searching Behavior;Sensory;Skin;Smell Perception;Source;SW opsin;Testing;Time;tool;Tsetse Flies;United States Department of Agriculture;vector mosquito;Vision;Visual;visual information;Visual Motion;visual search;Visual System;water vapor;Work;ZIKA

PROJECT_TITLE: Olfactory modulation of color vision and behavior in mosquitoes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(03)]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The fellows and mentors trained by this program will contribute to short- and long-term improvements in global health. In collaboration with 21 low- and middle-income country institutions, fellows’ research will help develop clear and effective programs and policies to advance global public health, including care for HIV, other infectious diseases, noncommunicable diseases, global surgery, cancer, mental health and addiction, sexual and reproductive health, and planetary health.

PI_NAMEs: COHEN, CRAIG R (contact);LEE, SUNG-JAE ;MARTIN, NATASHA ;MARTÍNEZ-LÓPEZ, BEATRIZ

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: burden of illness;California;career;career development;Collaborations;Country;Dentistry;design;Discipline;Discipline of Nursing;Ensure;Environmental Science;Equity;Evaluation;experience;faculty mentor;Faculty Recruitment;Fellowship;Fostering;Funding;global health;Goals;hands on research;Health;improved;Income;innovation;Institution;Instruction;Interdisciplinary Education;Leadership;Los Angeles;Medicine;Mentors;Mentorship;Modeling;online course;Personal Satisfaction;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Race;recruit;Research;Research Methodology;Resources;response;San Francisco;Site;Social Sciences;success;Training;Training and Education;Training Programs;Underrepresented Minority;Universities;veterinary science;Work

PROJECT_TITLE: GloCal - NCI - Kivuyo


NIH_SPENDING_CATS: Digestive Diseases

PHR: Project Narrative Cells elicit numerous behaviors to maintain the structure and function of tissues during both normal homeostasis and stress. The proposed study leverages the robustness of the Drosophila intestinal epithelium to investigate the principles underlying complex cell behaviors, which contribute to the maintenance of epithelial structure and function. Thus, the proposed study will promote our knowledge of how to keep epithelia healthy and prevent diseases associated with abnormalities in epithelial homeostasis.

PI_NAMEs: KWON, YOUNG  (contact)

PROJECT_TITLE: Complex Cell Behaviors During Epithelial Homeostasis and Stress


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This application utilizes the T32 Supplement Program to Promote Diversity in Health Research (NOT-AT-24- 034) to expand our long established, successful NIH T32 training grant that has provided rigorous training to pre- and post-doctoral fellows who have become skilled leaders in CIH research. In this supplementary application, we propose a three-year training program for Victoria Yunez Behm, a mater’s trained leader in integrative nutrition who has been accepted into UNC’s nutrition PhD program and is committed to extending multicomponent integrative health interventions to vulnerable communities. Ms. Behm will learn qualitative and quantitative methods and community engaged research as well as mind-body research methods for vulnerable populations, under the mentorship of Drs. Ammerman, Gaylord, and Faurot – all UNC faculty and T32 mentors.

PI_NAMEs: FAUROT, KETURAH RUTH;GAYLORD, SUSAN  (contact);GISCOMBE, CHERYL L

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: pre-doctoral

PROJECT_TITLE: T32 Predoctoral Diversity Supplement for Victoria Behm


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framedwithin our project research theme of health equity.

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skills;Slum;South America;Substance abuse problem;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Global Health Equity Scholars Program - Melikam


PHR: PROJECT NARRATIVE This application utilizes the Complementary and Integrative Health (CIH) Practitioner Supplement to expand our long established, successful NIH T32 training grant that has provided rigorous training to pre- and post- doctoral fellows who have become skilled leaders in CIH research. In this supplementary application, we propose a two-year training program for Dr. Rebecca Molinini, a promising future leader with a doctoral degree in Physical Therapy and a PhD in Rehabilitation and Movement Sciences who is committed to research in mind-body therapies for enhancing the parent-child relationship as part of the rehabilitation process for preterm infants. Dr. Molinini will learn mind-body therapy research methods, neuroimaging/EEG, and be trained in safety, efficacy, effectiveness, and implementation strategies for integrating effective CIH therapies into health care practice.

PROJECT_TERMS: Complementary Health;Integrative Medicine;National Center for Complementary and Integrative Health

PROJECT_TITLE: NCCIH T32 Complementary and Integrative Health Practitioner Supplement (Molinini)


NIH_SPENDING_CATS: Aging;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;Montenegro;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skill acquisition;Slum;South America;Substance abuse problem;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Global Health Equity Scholars Program - Montenegro-Idrogo


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative – from parent grant Recent discoveries that allow us to look beyond the one-dimensional sequence of DNA and understand the large-scale organization principals of its three-dimensional folding have been limited when it comes to characterizing the role of fine-scale genetic variations of the DNA code in controlling important cellular processes such as gene expression. This work will employ state-of-the-art molecular biology techniques and develop novel computational methods to define the role of such genetic variants in changing three-dimensional connections made by the promoters of genes in the human genome. This systematic and unbiased genome- wide study will have important implications in changing the way we study the disease relevance of genetic variation by revealing genotype dependence of long-range chromatin interactions between genes and their distal control switches at a scale that has not been achieved to date.

PI_NAMEs: AY, FERHAT  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 3-Dimensional;Address;Affect;Asthma;Binding;Biological;Biological Assay;Cell Physiology;cell type;Chromatin;Chromatin Structure;chromosome conformation capture;Code;Collaborations;Computer Analysis;Computing Methodologies;Dependence;Disease;Disease susceptibility;Distal;DNA;DNA Sequence;Experimental Designs;Gene Expression;Gene Expression Regulation;Gene Structure;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genome-wide analysis;Genotype;Goals;graph theory;histone modification;Human;Human Genetics;Human Genome;Immune;Knowledge;Laboratories;Machine Learning;Maps;Molecular Biology Techniques;novel;parent grant;Population;Positioning Attribute;predictive modeling;Predisposition;programs;promoter;Quantitative Trait Loci;Research;Resources;Role;Sampling;Specificity;statistics;Susceptibility Gene;transcription factor;Uncertainty;Untranslated RNA;Variant;Work

PROJECT_TITLE: Studying the function of human genetic variation in the light of 3D genome organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Mental Health;Neurosciences;Rehabilitation;Stroke

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative: Relevance to Public Health This project examines how cognitive abilities impact the recovery of language in individuals during the acute to chronic stages of stroke. Assessing these abilities over time while collecting neural information will enable us identify patterns of co-occurrence to gain predictive power about what types of brain damage and behavior lead to chronic communicative loss. As a result, we will be able to provide a clear path to improved diagnosis and treatment of communicative difficulties following right hemisphere stroke.

PI_NAMEs: BLAKE, MARGARET LEHMAN;SCHNUR, TATIANA TAMARA (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acute;acute stroke;Address;Affect;Aphasia;Area;Attention;Behavior assessment;behavior measurement;Behavioral;Behavioral Mechanisms;Brain;brain behavior;Brain Injuries;Brain region;Chronic;chronic stroke;cognitive ability;Cognitive deficits;cohort;Communication;Communication impairment;Comprehension;Country;Cues;Data;Dependence;Diagnosis;Emotional;Evolution;executive function;Facial Expression;Frequencies;Goals;health care availability;Humor;Improve Access;improved;inclusion criteria;Individual;Individual Differences;Inferior;innovation;Intervention;Knowledge;Laboratories;Language;language comprehension;Language Disorders;Lead;Left;Lesion;Life;longitudinal analysis;Longitudinal Studies;Maps;Measures;Metaphor;Methods;Modeling;neural;Neuroanatomy;neuroimaging;neuromechanism;Neuropsychological Tests;non-verbal;Outcome;Parietal;patient population;Patients;Pattern;perspective taking;post stroke;predictive modeling;Probability;Production;Public Health;Quality of life;Recovery;recruit;Rehabilitation therapy;Right cerebral hemisphere;Sample Size;Short-Term Memory;social;social communication;social deficits;Social Interaction;Speech;Stroke;Structure;Symptoms;Testing;theories;theory of mind;Time;tool;white matter

PROJECT_TITLE: Recovery of language and theory of mind after stroke

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Genetics;Nanotechnology

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The proposed research will use DNA nanotechnology to develop a new generation of molecular tension probes and nanodevices to be used in mechanobiology and structural biology. If successful, the project will provide answers to many important questions related to T cell signaling and activation, and impact the development of new immunotherapeutic methods. It will also open up a new paradigm for understanding mechano-biological processes involving other protein mechanosensors.

PI_NAMEs: KE, YONGGANG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Adaptive Immune System;Address;Autoimmunity;B-Lymphocytes;Binding;bioimaging;Biological Process;biological research;biological systems;Biomedical Research;Biosensing Techniques;cancer therapy;Cell surface;Cells;Cellular biology;Collaborations;Complex;Cryoelectron Microscopy;Detection;Development;Devices;Disease;DNA;DNA Structure;Generations;Immune system;Immunotherapeutic agent;improved;in vivo;Lymphocyte;Malignant Neoplasms;mechanical signal;Mechanoreceptors;Messenger RNA;Methods;Molecular;Molecular Conformation;Molecular Probes;multidisciplinary;Nanoarray Analytical Device;nanodevice;Nanostructures;Nanotechnology;next generation;novel;Positioning Attribute;Process;Proteins;Publishing;Reaction;receptor;Regulation;Research;Research Activity;self assembly;sensor;Signal Transduction;single molecule;small molecule therapeutics;Small RNA;structural biology;synergism;System;T-Lymphocyte;targeted treatment;tool;ultra high resolution;Virus Diseases;Visualization;Work

PROJECT_TITLE: DNA nanodevices for molecular interrogation and regulation of lymphocytes in adaptive immune system


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative: To combat diseases, it is essential to study the function of biomolecules to understand the underlying disease mechanisms. Multi-frequency Electron Spin Resonance (ESR) spectroscopy, which is a powerful method to study functional dynamics of proteins, lacks sufficient sensitivity and resolution to carry out studies at physiological concentrations and longer time scales. The proposed research will develop computational methods to improve signal resolution in ESR spectroscopy, enabling better understanding of disease mechanisms for more effective therapies, thus benefiting the public health.

PI_NAMEs: SRIVASTAVA, MADHUR  (contact)

PROJECT_TERMS: Address;Adopted;Biological;biological systems;biophysical techniques;combat;Complex;computerized data processing;Computing Methodologies;data acquisition;denoising;Development;Dimensions;Disease;drug development;Early Diagnosis;effective therapy;Electron Spin Resonance Spectroscopy;Environment;Foundations;Frequencies;frontier;improved;instrument;Knowledge;Lipids;Measurement;Membrane;Methods;Molecular Conformation;Motion;Muramidase;Noise;Physiological;Play;Protein Conformation;Protein Dynamics;Proteins;Public Health;Recovery;Research;Resolution;Signal Pathway;signal processing;Signal Transduction;Structure;Temperature;Time;Uncertainty

PROJECT_TITLE: Room Temperature Protein Conformational Dynamics at Microsecond Timescales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(54)-R]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE The proposed study will complement the larger project and will train an early career researcher in implementation science methodology, training and intervention development, and grantsmanship in order for her to gain research independence. The parent project, and by extension, the proposed project, aims to transform mental health care by addressing both supply and demand side barriers through provision of accessible and evidence-based care delivered by racially and culturally congruent providers; enabling care to be delivered regardless of a formal diagnosis; and empowering majority-minority, mostly first-generation college-attending students to acquire the skills to respond and become change agents for their communities. The proposed project will not only act as an immersive career development and training experience for the applicant, but will create an intervention for trauma-focused care in an emergency medical setting that has important implications for further dissemination and widespread understanding of the organizational and contextual factors which act as barriers to implementation of evidence-based interventions and can serve as a blueprint for broader scope and reach of mental health care to address the mental health needs of racial and ethnic minority groups in low resourced communities who experience disparities in access and outcomes.

PI_NAMEs: SANCHEZ, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: acceptability and feasibility;access disparities;Accident and Emergency department;Address;Anxiety;associated symptom;Attention;Award;Behavioral;Birds;brief intervention;care seeking;career;career development;Caring;Certification;college;Communities;Community Health;Community Health Aides;community violence;Complement;Consultations;contextual factors;coping;Coping Skills;cost;COVID-19;Data;Development;Diagnosis;Disparity;disparity reduction;Diverse Workforce;Domestic Violence;Early Intervention;Education;Educational Curriculum;effective therapy;efficacious treatment;Emergency department visit;empowerment;Ensure;Equity;ethnic diversity;ethnic minority;ethnic minority population;evidence base;Evidence based intervention;experience;Focus Groups;Foundations;Generations;Health care facility;health disparity;Health Personnel;Health Services Accessibility;Healthcare;Homelessness;implementation barriers;implementation science;Improve Access;indicated prevention;Individual;inequitable distribution;informant;Intervention;Interview;Knowledge;Medical;Medical Care Costs;Medical emergency;medical schools;Mental Depression;Mental Health;Mental Health Services;Mentors;Methodology;Migrant;migration;Minority;Modeling;Names;National Institute of Mental Health;Natural Disasters;neighborhood disadvantage;Outcome;Overutilization of Health Services;parent grant;parent project;Patients;peer;physical conditioning;Population;Population Group;Prevention;preventive intervention;Problem Solving;Process;Provider;Psyche structure;Psychiatric Hospitals;psychoeducation;quality assurance;Quality of Care;Race;racial diversity;racial minority;racial minority population;Research;Research Personnel;Resource-limited setting;Resources;Review Literature;Risk;Role;screening;Side;skill acquisition;skills;social determinants;social health determinants;Social support;Social Work;Social Workers;Students;substance use;Supervision;Symptoms;Testing;therapy development;Time;tool;Training;Trauma;traumatic event;traumatic stress;undergraduate student;Underserved Population;United States

PROJECT_TITLE: Train and EMPOWER A Community Health workforce to achieve equity and reduce disparities in mental health (TEACH)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Disability Research;Headaches;Mental Health;Mental Illness;Migraine;Neurosciences;Pain Research;Rehabilitation;Telehealth

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: DETAILED DESCRIPTION Migraine is a common, painful and disabling disorder; depressive symptoms are often comorbid with in people with migraine and increase suffering. The goal of this project is to evaluate the fidelity, feasibility, and acceptability of remote-delivered (telephone and video) mindfulness-based cognitive therapy (MBCT) for migraine disability and depressive symptoms. We will use pre-specified decision rules to determine study design for a future phase III clinical trial of remote-delivered MBCT.

PI_NAMEs: SENG-TAMACCIO, ELIZABETH K;SHALLCROSS, AMANDA J (contact)

PROJECT_TERMS: Abbreviations;Absenteeism at work;acceptability and feasibility;Address;Adherence;Area;arm;associated symptom;Behavioral;Certification;Chronic;Chronic Disease;chronic pain;chronic painful condition;Classification;Client satisfaction;Clinical;Code;common symptom;comorbidity;Competence;Comprehension;Data;depressive symptoms;design;Development;disability;Disabling;Disease;Economic Burden;Emotional;evidence base;Feasibility Studies;Feedback;Future;Genetic;Goals;Guidelines;Headache;Headache disability;Headache Disorders;Health;Health Services Accessibility;High Prevalence;Home;Hour;Hypertension;improved;Individual;innovation;Integrative Therapy;International;intervention delivery;Interview;Knowledge;Length;Light;Manuals;Measures;Medical Care Costs;Mental Depression;Mental Health;Migraine;Migraine disability;migraine treatment;Mind-Body Intervention;mindfulness based cognitive therapy;National Center for Complementary and Integrative Health;Nausea;Neurobiology;New York;Occupational;opioid therapy;Pain;pain symptom;Participant;Pathway interactions;patient engagement;Patients;Persons;Phase;Phase III Clinical Trials;phase III trial;pleasure;primary outcome;Procedures;Productivity;Protocols documentation;Questionnaires;Randomized, Controlled Trials;recruit;remote delivery;Reporting;Research Design;Research Personnel;retention rate;Site;social;sound;Specific qualifier value;Standardization;symposium;Telephone;telephone based;telephone delivery;telephone session;Therapeutic;therapy development;Training;treatment arm;treatment as usual;United States National Institutes of Health;video delivery;Videoconferencing;Vomiting

PROJECT_TITLE: Feasibility and Acceptability of Telephone-delivered MBCT for Migraine and Depression (FATE-MD)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Common viral respiratory infections, such as influenza and SARS-CoV-2, contribute to chronic lung disease. Following viral infection, airway repair mechanisms lead to differentiation of unexpected airway cell types within the lung, Microfold (M) and basal-like cells. This proposal will investigate the function of rare airway cell types during post-viral injury repair.

PI_NAMEs: BARR, JUSTINN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Aerosols;Air;airway epithelium;airway repair;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar fibrosis;Alveolus;Antibody Response;Antigens;Area;ATAC-seq;Bacterial Infections;Bioinformatics;Biological Assay;Biology;Bronchus-Associated Lymphoid Tissue;California;Cell Differentiation process;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;chemokine;Chromatin;Chronic;Chronic lung disease;Cicatrix;Communities;conditional knockout;Cre driver;Data;Distal;Environment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Epithelial Cells;Epithelium;experimental study;Future;Gases;Gene Expression;Genetic;Goals;Heterogeneity;Human;idiopathic pulmonary fibrosis;Immune;Immunologic Surveillance;Immunology;immunoregulation;in vivo;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;Inhalation;injured airway;Injury;injury and repair;Institution;Intestines;Knockout Mice;Lead;Lung;lung development;Lung Diseases;lung injury;lung repair;Lymphoid Follicle;M cell;Mentors;Mentorship;Molecular;Morbidity - disease rate;mouse model;mucosa-associated lymphoid tissue;Mucosal Immune Responses;mucosal site;Nasal Epithelium;Natural regeneration;Outcome;pathogen;Pathway interactions;Peyer's Patches;Physiology;Pneumonia;Postdoctoral Fellow;Predisposition;progenitor;programs;pulmonary function;Receptor Signaling;regenerative repair;regenerative therapy;Regulation;repaired;Research;resilience;Resolution;Resources;Respiratory System;Role;Secondary to;single nucleus RNA-sequencing;skills;Sorting;stem;stem cells;Submucosa;Surface;Surveys;Testing;Tissues;Tracheal Epithelium;Training;transcription factor;Universities;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Rare Airway Cell Function in Post-Viral Chronic Inflammation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed “Research Supplement to Promote Diversity in Health-Related Research” builds on the parent grant (R01-MD015165: Multilevel Physical Activity Intervention for Low Income Public Housing Residents) to test a multi-level intervention aimed at increasing physical activity among public housing residents. This supplement will support the career goals of Dr. Brennan Rhodes-Bratton, a social epidemiologist focused on chronic disease prevention in minoritized communities. Using data from the Community Walks clinical trial, Dr. Rhodes-Bratton aims to examine the impact of gentrification and health habitus on moderate-intensity physical activity among public housing residents in Boston, Massachusetts, employing an explanatory sequential design with semi-structured interviews to interpret quantitative data findings; results will be used to determine strategies for improving chronic disease prevention interventions among minoritized groups.

PI_NAMEs: QUINTILIANI, LISA M. (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adult;Aerobic;Age;American;arm;Attitude;Behavioral;Boston;career;Chronic Disease;Clinical Trials;Communities;Complex;Data;design;Development;disorder prevention;Disparity;Environmental Risk Factor;Epidemiologist;Ethnic Population;exercise intervention;follow-up;Goals;Guidelines;Health;Health behavior;Health Benefit;health determinants;health disparity;health equity;improved;Individual;Institutional Racism;Intervention;Intervention Trial;Interview;Learning;Low income;Massachusetts;Methods;minority communities;Minority Groups;Motivation;Neighborhoods;parent grant;parent project;Participant;Physical activity;Population;preventive intervention;Process;Proxy;Psychosocial Factor;Public Housing;Quality of life;racial population;Recommendation;Research;Research Design;Research Personnel;Risk Reduction;sedentary;Self Efficacy;social;social factors;socioeconomics;strength training;Structure;success;Surveys;Testing;theories;treatment arm;United States;Walking;walking intervention

PROJECT_TITLE: Multilevel Physical Activity Intervention For Low Income Public Housing Residents - Diversity Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Lung;Pediatric;Prevention;Rare Diseases;Sleep Research

PHR: PROJECT NARRATIVE The goal of this study is to advance a bed sensing technology platform through real-world patient testing. Doing so will improve our ability to recognize the earliest signs of impending hospitalizations in high-risk patients, days to weeks before symptoms are self-recognized and self-reported.

PI_NAMEs: KING, KEVIN R (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: actigraphy;Adherence;Administrative Supplement;Adoption;Adult;Algorithms;Arrhythmia;Assessment tool;Ballistocardiography;Beds;Blood;Cardiac;cardiac implant;cardiac magnetic resonance imaging;Cardioscopes;Caring;Charge;Chest;Chronic Obstructive Pulmonary Disease;Clinical;cost;County;Dangerousness;Data;Data Set;Defibrillators;design;detection method;detection platform;detector;Devices;Disease;Early Diagnosis;Electrocardiogram;epidemiology study;Funding;Future;Goals;Grant;Heart;Heart Diseases;Heart failure;Hematological Disease;hemodynamics;high risk;Home;Hospitalization;Human;Implantation procedure;improved;Individual;Intervention;Learning;Life;Longitudinal Studies;Lung;Lung Diseases;Malignant - descriptor;Mattresses;Mechanics;Mitral Valve;Mitral Valve Prolapse;model generalizability;Modeling;Monitor;Obstructive Sleep Apnea;Operative Surgical Procedures;Parents;Participant;Patient Self-Report;patient subsets;Patients;Physiological;Play;Pneumonia;Polysomnography;prospective test;Reporting;respiratory;Risk;Risk Assessment;screening;sensor;sensor technology;Signal Transduction;Sleep;Sleep Disorders;Spirometry;success;sudden cardiac death;Symptoms;Technology;Technology Assessment;technology platform;Testing;Time;Training;training data;Underrepresented Populations;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;wearable monitor

PROJECT_TITLE: Advancement of an Impending Hospitalization Detection Platform


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Interstitial Cystitis;Natural Products;Neurosciences;Pain Research;Urologic Diseases;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Interstitial cystitis/ bladder pain syndrome (IC/BPS) is one of the most debilitating chronic pelvic pain (CPP) conditions that negatively impacts the quality of life and sexual activities in 2.7% to 6.5% of women in the US. Botulinum neurotoxin (BoNT) has received growing interest in managing IC/BPS, but it can cause dose- dependent adverse effects and is expensive. This research represents the first effort develop a personalized, precision BoNT injection approach guided by intra-vaginal high-density surface EMG to optimize the treatment outcome in IC/BPS management.

PI_NAMEs: ZHANG, YINGCHUN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Acetylcholine;Adverse effects;Alternative Therapies;botulinum neurotoxin injection;botulinum toxin treatment;Botulinum Toxins;Chemicals;Chronic;chronic pelvic pain;Clinical;Clinical Trials;Crossover Design;Data;density;Diagnosis;Disease;dosage;Dose;efficacy testing;Electromyography;Ensure;Etiology;Feasibility Studies;Foundations;Functional disorder;Future;Goals;Hyperalgesia;Image;Impairment;improved;in vivo;Individual;Inflammatory;Injections;interest;Interstitial Cystitis;Maps;Methods;Mission;Muscle;Muscle relaxants;Muscle relaxation phase;Muscle Spasticity;National Institute of Diabetes and Digestive and Kidney Diseases;nerve supply;Neuromuscular Junction;neuromuscular transmission;Nociceptors;novel;optimal treatments;Oral;Pain;pain relief;pain symptom;Patients;Pattern;Pelvic Floor Muscle;Pelvic floor structure;Pelvic Pain;Pelvis;personalized approach;Phenotype;Physical therapy;Protocols documentation;Quality of life;Randomized;Randomized Controlled Clinical Trials;recruit;Relaxation;Research;research clinical testing;response;Safety;Secondary to;Severities;Sex Behavior;Site;Skeletal Muscle;success;Surface;Techniques;Therapeutic Intervention;tool;Training;Treatment Cost;Treatment Efficacy;treatment optimization;Treatment outcome;treatment strategy;Woman;women's diagnosis

PROJECT_TITLE: High-Density Surface Electromyography Guided Precision Botulinum Neurotoxin Injections to Manage Chronic Pelvic Floor Pain

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE The development of new life-saving medicines requires access to new chemical structures with unprecedented structures. We are interested in designing new reactions that harness the energy of light to generate highly reactive intermediates that engage in reactions that cannot be accomplished using standard non-photochemical strategies. The focus of our research is the design of catalysts that can control the outcomes of these high-energy reactions in predictable ways.

PI_NAMEs: YOON, TEHSHIK P (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: SYNTHETIC PHOTOCHEMISTRY


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Mechanistic concepts from model organisms are used to translate ideas for therapeutics, vaccine design, managing infectious diseases and immune pathologies into humans. Mice are one of the most widely used preclinical models of human immunity, and the studies in our proposal will aid in predicting how structural variation between the genomes of model organisms and the human genome contribute to humans acquiring (or losing) cell-type and stimulation-dependent gene expression patterns and functions in immune cells.

PI_NAMEs: WEINMANN, AMY SUSAN (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Affect;Attention;Biomedical Research;Buffers;Categories;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromosomal Rearrangement;Chromosomes;Clinical Trials;combat;Communicable Diseases;Conserved Sequence;Data Set;differential expression;DNA Sequence;Elements;Enhancers;Event;Foundations;Gene Cluster;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;Genes;Genetic;Genetic Enhancer Element;Genome;Genomic approach;Genomics;Grant;Human;Human Genome;human model;Immune;Immune response;Immunity;Immunological Models;Immunologics;Immunology;improved;inducible gene expression;inhibitor;insertion/deletion mutation;insight;Knowledge;Location;Macrophage;model organism;mouse genome;mouse model;Mus;NOS2A gene;novel;pathogen;Pathogenicity;Pathology;Patients;Play;Positioning Attribute;Pre-Clinical Model;preclinical study;preference;pressure;prevent;Primates;promoter;Regulation;Regulatory Element;Research;response;Rodent;Role;Site;Technology;Testing;Therapeutic;tool;Translating;Translocation Breakpoint;Trees;Vaccine Design;Variant

PROJECT_TITLE: Genome organization, evolutionary structural variation, and gene regulation in immunity


PHR: Project Narrative Antimetabolite chemotherapies are being repurposed to treat immunopathologies, however, significant side- effects occur in patients because antimetabolites alter metabolism in many cell types, not just the pathogenic cell populations. To predict the effects of antimetabolite or nutrient interventions in therapeutic settings, we need to understand the conserved and cell-type specific mechanisms by which metabolites influence cellular programming potential.

PROJECT_TERMS: 3-Dimensional;Acetates;Acetyltransferase;Address;alpha ketoglutarate;Antigens;Antimetabolites;Binding;Butyrates;cancer cell;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell surface;cell type;Cells;Cellular Structures;chemotherapy;cofactor;Communicable Diseases;Complex;cytokine;Data;Deacetylase;Development;Diet;dietary;Dietary Intervention;Disease;DNA;DNA Methylation;Elements;Enhancers;Environment;Epigenetic Process;Event;functional outcomes;Funding;Genes;Genetic Variation;Genome;Genomics;Glutamine;Grant;Histone Acetylation;histone methylation;Histones;Human;Human Genome;Immune;Immune response;Immune System Diseases;Immunology;immunopathology;Individual;Infection;interest;Interleukin-2;Intervention;Location;Memory;Metabolic;Metabolism;microbiome;Modification;Molecular;mouse genome;Mus;Nutrient;pathogen;Pathogenicity;Patients;Pattern;Play;Population;Process;programs;receptor;recruit;Regulation;Regulatory Element;response;Role;side effect;Site;Specificity;T-Lymphocyte;Therapeutic;transcription factor;Variant;Volatile Fatty Acids

PROJECT_TITLE: Molecular characterization of the role for metabolites in immune cell differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-C(02)]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Regenerative Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This Project Narrative was originally submitted with T32GM141742 and is included here unchanged to satisfy submission system requirements. PROJECT NARRATIVE The goal of this training program is to train a diverse group of scientists to solve problems relevant to human health, including developmental diseases. Predoctoral students will learn to responsibly conduct research in genetics, developmental, cell and stem cell biology and gain important communication and professional skills.

PI_NAMEs: APPEL, BRUCE H;MOORE, JEFFREY KYLE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Predoctoral Training in the Genetics of Development, Disease and Regeneration

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Access to and receipt of high-quality survivorship care is of paramount importance for survivors of young adult (YA) cancers, who experience long-term risks across multiple health domains and have many life-years to live. This supplement will assess alignment between the new National Standards for Survivorship Care and a survivorship care program that serves diverse YAs; access to and utilization of survivorship care among diverse YAs; and identify multi-level gaps for future development. Findings of this study will illuminate opportunity areas for YA cancer survivorship care delivery in alignment with the new National Standards, and, thereby, inform efforts to develop and implement high-quality survivorship programs that serve and engage diverse YA survivors.

PI_NAMEs: MILLER, KIMBERLY ANN (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: access disparities;active method;Address;Administrative Supplement;Administrator;Area;Behavior;California;Cancer Center;cancer diagnosis;Cancer Survivor;cancer survivorship care;cancer therapy;care delivery;Caring;Characteristics;Childhood;Chronic;Chronic Disease;Clinic;Clinical;Communities;Comprehensive Cancer Center;Continuance of life;Country;Data;Development;Diagnosis;Disparity;early onset;Eligibility Determination;ethnic disparity;ethnic diversity;Ethnic Origin;experience;Face;Fertility;financial toxicity;Future;Health;Health behavior;health inequalities;Healthcare Systems;Hospitals;Impairment;improved outcome;Infertility;Insurance;interest;Interview;Knowledge;Life;Longitudinal Studies;Los Angeles;Malignant Neoplasms;Medical center;medically underserved;meetings;Methods;Not Hispanic or Latino;older adult;Outcome;Parents;Participant;Physicians;Population;Privatization;programs;Provider;psychological distress;public health insurance;Quality of Care;Quality of life;Race;racial disparity;racial diversity;racial minority;Reporting;Research;Resources;response;Risk;safety net;Sampling;Second Primary Cancers;Site;social;sociodemographics;Surveys;Survivors;survivorship;Universities;Utilization Review;Visit;young adult

PROJECT_TITLE: Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A longitudinal Study Administrative Supplement


NIH_SPENDING_CATS: Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Natural Products;Opioids;Pain Research;Therapeutic Cannabinoid Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative (Parent Award) The United States is in the midst of a nationwide opioid epidemic; terpenes hold promise as novel pharmacotherapeutic strategies to reduce reliance on opioids for pain management. The proposed double-blind, placebo-controlled studies will be the first to rigorously assess the dose- dependent analgesic effects of ecologically-relevant doses of two terpenes with robust preclinical promise, myrcene and ßcaryophyllene, and determine their THC- and opioid-sparing effects. Findings from these studies will be essential to developing these terpenes as innovative therapeutics to treat pain to aid in the effort to decrease dependence on opioids as analgesics.

PI_NAMEs: COOPER, ZIVA D (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;abuse liability;Address;Adverse effects;adverse outcome;Analgesics;antinociception;Area;Beta-caryophyllene;cannabinoid treatment;Cannabis;Chemicals;chronic pain;chronic pain management;Clinical;Dependence;Dose;Double-Blind Method;effective therapy;Human;Individual;innovation;interest;Intoxication;marijuana smoker;Mediating;mu opioid receptors;Naltrexone;Nature;novel;novel therapeutics;Opioid;Opioid Antagonist;opioid epidemic;opioid sparing;Pain;Pain management;pain relief;parent project;Placebo Control;placebo controlled study;pre-clinical;pre-clinical research;Property;Public Health;public health priorities;Recreation;Research;Study Subject;Terpenes;Testing;Tetrahydrocannabinol;Therapeutic;therapeutic candidate;Therapeutic Effect;Time;Translating;United States

PROJECT_TITLE: Analgesic and subjective effects of terpenes administered alone and in combination with THC: Potential THC- and opioid-sparing effects of myrcene and ß-caryophyllene


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Glioblastomas (GBMs) or grade IV gliomas are aggressive brain tumors affecting about 18,000 Americans every year with a median survival of only 12-15 months. We have found new evidence that the transcription co-factors, YAP/TAZ are integral components of DNA damage repair on neurogenic enhancers, regions that are selectively vulnerable to double stranded breaks. In this proposal, we will use a combination of classic molecular biology assays and state-of-the-art epigenomic technologies to understand the mechanistic underpinnings of therapy resistance in GBM and target the YAP/TAZ pathway using novel pharmacological inhibitors to overcome therapy resistance in GBM.

PI_NAMEs: BHAT, KRISHNA PL (contact);LI, WENBO

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Aggressive behavior;American;Architecture;Binding;Biochemical;Biological;Biological Assay;Biology;Brain Neoplasms;cancer clinical trial;cancer type;Catalytic Domain;Cells;ChIP-seq;Chromatin;Chromatin Structure;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohesin;cohesion;Complex;confocal imaging;Cytotoxic Chemotherapy;Data;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA-dependent protein kinase;Double Strand Break Repair;Enhancers;epigenomics;Genes;Genetic Transcription;Genome;Glioblastoma;Glioma;Growth;Heterochromatin;Hi-C;immune checkpoint blockade;improved;In Vitro;in vitro Assay;in vivo;inhibitor;Ionizing radiation;irradiation;Kinetics;Knowledge;Malignant neoplasm of brain;Mediating;Mesenchymal;Molecular;Molecular Biology;mouse model;Mus;Necrosis;Neighborhoods;Neuronal Differentiation;Neurons;next generation;Nonhomologous DNA End Joining;novel;novel therapeutics;Nuclear Translocation;Oncogenic;Outcome;overexpression;paralogous gene;Pathway interactions;Patients;pharmacologic;Phosphorylation;Play;Pre-Clinical Model;Precision Run-On Sequencing;programs;protein complex;Proteins;radiation resistance;Radiation therapy;Radiosensitization;recruit;Recurrent tumor;Reducing Agents;Reporter;Resistance;response;Role;Scaffolding Protein;Serine;Site;stem;stem-like cell;Structure;Survival Analysis;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Threonine;transcription factor;Transcription Factor AP-1;transdifferentiation;tumor ablation;tumor growth;tumor progression;Verteporfin;Xenograft procedure;XRCC5 gene

PROJECT_TITLE: Novel Roles of TAZ and YAP in DNA Damage Repair with 3D Genome Organization and the Therapeutic Resistance in Glioblastoma

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Administrator;Advisory Committees;Arkansas;Bioenergetics;Biomedical Research;career development;Cells;Centers of Research Excellence;cohort;Collaborations;Core Facility;Data Science;Development;Development Plans;Disease;empowerment;Ensure;Evaluation;Faculty;faculty mentor;Faculty Recruitment;Funding;Funding Opportunities;Goals;Image;imaging science;Interdisciplinary Study;member;Mentors;Mentorship;Metabolic;metabolic imaging;Metabolism;Methods;Optics;Phase;Pilot Projects;Productivity;programs;repaired;Research;Research Infrastructure;Research Personnel;Research Support;Resource Allocation;Role;Secure;Spectrum Analysis;success;Teacher Professional Development;Technology;Tissues;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PI_NAMEs: RONINSON, IGOR B (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Advisory Committees;Applications Grants;career development;Centers of Research Excellence;Charge;Clinical;Collaborations;Communication;Communities;Complement;Data;Development;Ensure;Environment;epigenetic aging;Evaluation;Faculty;Fostering;Funding;Generations;Individual;Institution;Internet;Manuscripts;Mediating;meetings;Mentors;motherhood;National Institute of General Medical Sciences;Pair Bond;Pilot Projects;Program Evaluation;programs;Progress Reports;recruit;Reporting;Research;Research Personnel;Science;Scientist;Senior Scientist;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Structure;success;symposium;targeted treatment;Time;Training;translational therapeutics;Visit

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation will conduct research to advance scientific discovery, implement novel interventions, promote cross-center collaboration, increase research capacity, and engage operational partners to improve Veteran health. Our research will focus on the public health threat of antibiotic resistance, on mitigating health risks in Veterans during periods of vulnerability, and on improving medication safety as the Department of Veterans Affairs (VA) transitions to a new electronic health record. Across all of these areas, we study methods to promote the adoption of research findings into clinical practice. In the process, we train the next generation of outstanding VA health services researchers. Veteran and stakeholder engagement is a topmost priority for our Center. All of our research is highly collaborative and integrated with clinical programs.

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TERMS: addiction;Adoption;adverse outcome;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Area;biomedical informatics;Caring;Cities;Clinical;Clinical Investigator;clinical practice;Cognitive;Collaborations;Community Healthcare;Coupled;Data;Decision Making;Decision Support Systems;design;Discipline;Electronic Health Record;Ensure;Environment;Event;Goals;Guidelines;hazard;Health;health care delivery;health information technology;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;implementation science;improved;Infection prevention;Informatics;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Link;medication safety;Medicine;Mental Health;Methodology;Methods;Military Personnel;Modernization;Natural Language Processing;Nature;next generation;novel;Overdose;patient safety;Pharmacoepidemiology;Population;prediction algorithm;Process;programs;Public Health;Qualitative Research;recruit;Research;Research Activity;Research Personnel;Risk;Rural Health;Safety;Science;Scientific Advances and Accomplishments;simulation;Sodium Chloride;Source;stakeholder perspectives;Statistical Models;success;suicidal;System;Therapeutic;tool;Training;Translational Research;Traumatic Brain Injury;Trust;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vision;Visualization

PROJECT_TITLE: IDEAS 3.0

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

PHR: The mission of the Center for Care Delivery and Outcomes Research (CCDOR) is to develop and evaluate interventions and implementation strategies that improve health care delivery, Veteran engagement in health care, and Veterans' health and functioning in their communities. CCDOR's vision is to elevate the quality, consistency and equity of health care and outcomes for all Veterans through innovative health services and implementation research. CCDOR is a vibrant health services research center of 26 core investigators leading research in Trauma Recovery (Priority 1) and Chronic Pain and Opioid Harms Reduction (Priority 2), as well as conducting and promoting research in additional areas including cancer prevention and control, health aging, and other timely topics. CCDOR has deep and strong partnerships with VA Program Offices, including the Office of Mental Health and Suicide Prevention, the National Center for PTSD, and National Pain Management. These and other partnerships ensure the value and impact of Center research.

PI_NAMEs: FU, STEVEN  (contact)

PROJECT_TERMS: acronyms;Aging;Area;Cancer Control;cancer prevention;care delivery;care outcomes;chronic pain;Communities;community based participatory research;community engagement;data management;Dedications;Disease;Ensure;Equitable healthcare;Evidence based practice;experience;Family;functional outcomes;Goals;Harm Reduction;Health;health care delivery;Health Services;Health Services Research;health training;Healthcare;Healthcare Systems;healthy aging;implementation research;implementation strategy;improved;Informatics;innovation;Intervention;Mental Health;Mentors;Methodology;Methods;Mission;Names;Opioid;Outcome;Outcomes Research;Pain management;Pain Research;Positioning Attribute;Post-Traumatic Stress Disorders;preservation;programs;Research;Research Personnel;Resources;Services;statistics;Strategic Planning;Structure;success;Suicide prevention;Training;Trauma;Trauma recovery;Veterans;Vision


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The Veterans Health Administration (VA) provides care for individuals who are more likely to be racial and ethnic minorities, older, and poorer than the general population. Although VA provides a health care safety net, disparities in health and health care exist for many vulnerable Veteran populations and are associated with increased risks of disability, illness, and death. In addition to individual, provider, and health system factors, disparities may originate outside of the health care system and involve personal behaviors and social and community influences. As a health system committed to delivering high-quality, equitable care to all Veterans, VA must identify vulnerable populations, understand the root causes of disparities, and assess interventions to eliminate them. The Center for Health Equity Research and Promotion's mission is to advance the quality and equity of health and health care for vulnerable Veterans.

PI_NAMEs: FINE, MICHAEL JONAH (contact);LONG, JUDITH A

PROJECT_TERMS: Address;behavioral economics;Big Data;Caring;Cessation of life;Clinical;clinical care;clinical epidemiology;Clinical Trials;Collaborations;Communities;community advisory board;Community Healthcare;Data Analyses;Decision Analysis;design;Development;disability risk;Discipline;Disparity;Ensure;Equity;ethnic minority;General Population;Genomics;Goals;Health;Health behavior change;health disparity;health equity;Health equity research;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;medical specialties;medication safety;Mentors;Meta-Analysis;Methods;military veteran;Mission;Outcome;Pattern;Pennsylvania;Personal Behavior;Pharmacologic Substance;pharmacy benefit;Policies;Program Development;programs;Provider;Psychometrics;Publications;Qualitative Research;racial minority;Records;Research;Research Personnel;Research Training;Safety;safety net;Scientific Advances and Accomplishments;Services;Site;social;Technology Assessment;Therapeutic;tool;Training;Training and Education;Translating;Universities;Veterans;Veterans Health Administration;Vulnerable Populations;Work

PROJECT_TITLE: Center for Health Equity Research and Promotion (CHERP)


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: Not applicable

PI_NAMEs: KERR, EVE A (contact)

PROJECT_TERMS: Achievement;Adverse event;Alcohols;Area;Award;behavioral economics;Cannabis;care coordination;care delivery;career;Caring;Chronic;Cladribine;Clinical;clinical center;Clinical Management;Collaborations;Communities;Community Healthcare;Complex;Critical Illness;Data Collection;Development;digital data;Disease Progression;disorder prevention;Effectiveness;experience;Family;Funding;Future;Health;Health Promotion;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;high risk;Homogeneously Staining Region;Hospitalization;implementation research;improved;Infrastructure;innovation;Inpatients;Intervention;investigator training;Knowledge;Measurement;Measures;Mental Health;mHealth;Michigan;Mission;Modernization;multidisciplinary;opioid misuse;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patients;peer support;Performance;Physicians;Play;predictive modeling;Prevention;Primary Care Physician;Productivity;programs;Reporting;Research;Research Infrastructure;Research Personnel;Role;Safety;Scientist;screening;Services;square foot;suicidal risk;Suicide prevention;System;Technology;theories;tool;Training;United States National Institutes of Health;Veterans;Vision;Wages

PROJECT_TITLE: Ann Arbor COIN Renewal Application


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: The Center for Access and Delivery Research and Evaluation (CADRE) is seeking to renew its Center of Innovation (COIN) funding to advance research and improve access for Veterans. We aim to build upon our existing expertise, established operational partnerships, and long-term research objectives through prioritizing five overarching goals that align with our focused areas of research and emerging priorities. GOAL 1: Improve access to high quality care for rural Veterans through innovative applications of telehealth in specialty care, community care, and dual use. GOAL 2: Develop and evaluate interventions targeting the multidrug-resistant organism crisis. GOAL 3: Expand efforts in developing innovative health services research in three additional areas: (1) women’s health, (2) epidemic opioid use and substance use disorders, and (3) cardiovascular outcomes. GOAL 4: Continue the Center’s success in supporting mentored career development. GOAL 5: Promote Veteran engagement with recognition that Veterans are experts on Veteran experience.

PI_NAMEs: PERENCEVICH, ELI N (contact)

PROJECT_TERMS: Address;Area;barrier to care;Cardiovascular system;career development;Caring;Centers for Disease Control and Prevention (U.S.);Cities;Communities;Community Healthcare;connected care;design;digital intervention;Endocrinologist;Enrollment;Equity;Evaluation;experience;Face;Fertility;Funding;Goals;health care availability;Health Services Research;Healthcare Systems;Improve Access;improved;innovation;Internet;Intervention;Iowa;Leadership;medical specialties;meetings;Mentors;multi-drug resistant pathogen;operation;opioid epidemic;opioid use;Outcome;pharmacy benefit;Poverty;Prevention;Provider;Publishing;Quality of Care;Recommendation;reproductive;Research;Research Personnel;Research Priority;Resources;Rural;rural area;Rural Health;rural setting;Scientist;Services;Substance Use Disorder;success;telehealth;Universities;Veterans;Women's Health;Women's Health Services

PROJECT_TITLE: Center for Access & Delivery Research and Evaluation (CADRE)


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: The Houston Health Services Research & Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (IQuESt) has been continuously funded by HSR&D since 1990, providing strong scientific leadership and institutional infrastructure dedicated to a model of embedded health system research. We have a nearly 20-year tradition of conducting research in partnership with the health care delivery system and responding to its needs, making us pioneers in the execution of the learning health care system model in VHA. The IQuESt mission, “Improving health and well-being through innovations in health care delivery”, conveys our commitment to transformative and innovative research that is aligned with VHA national priorities. IQuESt is ideally poised to contribute to making care more accessible, safer, and more patient-centered with innovative research, rapid implementation of evidence, novel methodologies, solid partnerships, stakeholder engagement, career development of scientists, and infrastructure to promote the learning health care system in VHA.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: Biological Models;career development;Caring;Dedications;Effectiveness;Funding;Health;health care delivery;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Leadership;Learning;Methodology;Mission;Modeling;novel;patient oriented;Personal Satisfaction;Research;research and development;Safety;Scientist;Solid;System;systems research

PROJECT_TITLE: Center for Innovations in Quality, Effectiveness, and Safety (IQuESt)


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: The Center of Innovation for Complex Chronic Healthcare (CINCCH) is a HSR&D COIN based at Hines VA Hospital. CINCCH's mission is to conduct research to optimize coordination and contextualization of healthcare delivery and improve outcomes for Veterans with high priority neurologic conditions, disseminate and implement best evidence, and train future researchers. We utilize innovative direct observation methods to collect data that compliments other forms of data to assess quality and patient experiences. CINCCH collaborates with several VA Operations Partners and is affiliated with three universities in the Chicago area. In addition, we have established a Veterans Engagement Panel that provides feedback on grant proposals and dissemination activities. Our COIN's vision is to create the evidence and implement the findings to support and guide VA in providing the best care in the right place at the right time.

PI_NAMEs: WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Address;Antibiotics;Applications Grants;Appointment;Area;Award;bone health;Books;care coordination;career;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic;Chronic Care;Collaborations;Complex;Data;decubitus ulcer;Disease;Doctor of Medicine;Doctor of Philosophy;experience;Faculty;Feedback;Funding;Future;health care delivery;Health Care Research;Health Services;Healthcare;Homelessness;Homogeneously Staining Region;Hospitals;Illinois;improved;improved outcome;innovation;Institution;instrument;Kidney Diseases;Leadership;Life;Medicare;Mentors;Methods;Mission;Modeling;Modernization;Neurologic;operation;Paper;Patient-Centered Care;Patients;Persons;pharmacy benefit;Physical Medicine;Physical Rehabilitation;programs;Renal dialysis;Research;Research Personnel;Respiratory Tract Infections;Scientist;Services;Source;Spinal cord injury;telehealth;Time;Training;Universities;Veterans;Vision;Weight Gain;Weight maintenance regimen;Work


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This application proposes the continuation of a Center of Innovation (COIN), called the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center. The COIN builds on the successes of our existing PRIME Center at VA Connecticut Healthcare System. The goals of the PRIME Center are to conduct research to improve care for all Veterans with a specific focus on pain management and women's health. The Center also fosters innovative research in emerging areas like suicide prevention and CHOICE care. Through a Veteran Engagement Group, the Center strives to be Veteran-centric. Investigators provide research mentoring to train the next generation of VA health services researchers. To achieve its goals, the PRIME Center is supported by partnerships with VHA Patient Care Services and Operations leaders, especially the Pain Management Program and Women's Health Services, as well as a large number of cross-COIN and other VHA medical center collaborations.

PI_NAMEs: BASTIAN, LORI A (contact)

PROJECT_TERMS: Area;Award;behavioral health;Behavioral Sciences;care systems;career;career development;Caring;Chronic;Clinical;Collaborations;Complementary Medicine;Connecticut;Disparity;Eating Disorders;Education;Electronic Health Record;Fostering;gender difference;Goals;Health;health data;Health Services;Health Services Research;Healthcare;Healthcare Systems;High Prevalence;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Integrative Medicine;Intervention;Leadership;Medical;Medical center;Medical Informatics;medical schools;medical specialties;Mental Health Services;Mentors;Minority;Mission;multimodality;Neurology;New England;next generation;operation;Opioid;Pain;Pain management;Pain Research;Patient Care;Patient-Centered Care;Primary Care;programs;Reproductive Health;Research;Research Methodology;Research Personnel;sex;Strategic Planning;success;Suicide;Suicide prevention;System;Technology;Training;Veterans;Woman;Women's Health;Women's Health Services

PROJECT_TITLE: Pain, Research, Informatics, Multimorbidities, Education


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Given Veterans' increasing choices about where and how they receive care, successful coordination of care will require improving effective communication among a variety of individuals and entities, as well as improved management and use of health information. This project supports the Center for Health Information and Communication, of the U.S. Department of Veterans Affairs Health Services Research & Development Service. The Center's mission is to improve Veterans' health care through innovative research on health information, technology, and communication. The Center's vision is to improve Veterans' health through innovative applications of health information and health information systems that serve the population-based and interpersonal needs of patients and health professionals. The Center will generate knowledge about the impact of the Department's investment in health information technology, and will determine how systems-based and interpersonal communication of health information can improve delivery and outcomes of care.

PI_NAMEs: WEINER, MICHAEL  (contact)

PROJECT_TERMS: Address;alternative treatment;Area;cancer care;care coordination;care outcomes;career development;Caregivers;Caring;chronic pain;chronic pain management;Clinical;clinical decision support;clinical practice;Communication;Communities;computer human interaction;connected care;Decision Making;Dissemination and Implementation;Documentation;Electronic Health Record;Foundations;Funding;Goals;Health;health application;health communication;Health Information System;health information technology;Health Professional;Health Sciences;Health Services Research;Health Technology;Healthcare;improved;Individual;Information Management;innovation;Investments;Knowledge;Mediation;Mental disorders;Mental Health;Mentors;Mission;Office Management;operation;Opioid;Outcome;Pain management;Patients;person centered;Personal Communication;Pharmaceutical Preparations;Policies;population based;Positioning Attribute;programs;Provider;Publications;Research;research and development;Safety;Science;Scientist;Services;skills;Stroke;System;Technology;tool;Translations;Veterans;Veterans Health Administration;virtual;Vision;Work