NIH_SPENDING_CATS: Autoimmune Disease;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Necroptosis is a type of genetically encoded necrotic cell death that is associated with many human diseases, including cancer, inflammatory bowel disease, liver injury, pancreatitis, neurodegenerative disorders, and a diverse range of viral, bacterial, and fungal infections, including SARS-CoV-2. Here, we aim to decode the molecular mechanisms of necroptosis regulation at its execution stage. Our work will pave the way for future anti-microbial therapies, as well as treatments for diseases that involve necroptosis.

PI_NAMEs: NAJAFOV, AYAZ  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 2019-nCoV;Affect;Anti-viral Response;antimicrobial;Bacterial Infections;Caspase;Cell Death;Cell membrane;Cells;Development;Disease;Enzymes;Event;Future;Genetic;human disease;in vivo;Inflammatory;Inflammatory Bowel Diseases;Knock-out;Ligands;liver injury;Malignant Neoplasms;Mediating;Microbe;Molecular;Mycoses;Necrosis;Neurodegenerative Disorders;Pancreatitis;Pathogenesis;Permeability;Phenotype;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Regulation;RIPK1 gene;RIPK3 gene;Role;Rupture;Signal Transduction;structural determinants;Testing;Ubiquitination;Vaccinia virus;Virus Diseases;Water;Work

PROJECT_TITLE: Molecular Mechanisms of Programmed Necrosis Execution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE People with severe speech and motor impairment often have difficulty with accessing communication technology, which is increasingly based on interaction with computers. This project aims to develop new methods of interacting with computers via decoding newly discovered brain signals to provide restoration of movement and communication. Successful completion of this project could allow this marginalized segment of the US population to once again have the means to manage their health care, form meaningful relationships, have a means for recreation and entertainment, and interact socially with their health care providers and loved ones.

PI_NAMEs: HENDERSON, JAIMIE M (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Algorithms;Animals;Area;arm;arm movement;Artificial Arm;base;Bilateral;body map;Body part;Brain;brain computer interface;Cellular Phone;Cerebral hemisphere;Chronic;Clinical;Clinical Research;Clinical Trials;Code;Communication;Complex;Computers;Creativeness;Data;design;Devices;Dimensions;Educational process of instructing;Enrollment;Esthesia;exoskeleton;experience;Face;functional restoration;Generations;Goals;Hand;Handwriting;Head;Health Personnel;Healthcare;Human;Implant;Individual;Institution;Investigation;Knowledge;Leg;Length;Limb structure;Link;loved ones;marginalization;Medial;Mental Processes;Methods;Motion;Motor;Motor Cortex;motor impairment;Movement;Muscle;Nervous System Disorder;Nervous System Trauma;neural;neuroethics;neuromechanism;Neurons;neurophysiology;Neurosciences;next generation;nonhuman primate;novel;Paralysed;Performance;Persons;Population;pre-clinical research;Precentral gyrus;Prosthesis;Quadriplegia;Recreation;Reporting;Research Support;Resolution;restoration;Safety;safety assessment;Seminal;Signal Transduction;Site;Social Interaction;Speech;Speed;System;Technology;Text;Time;Translating;United States National Institutes of Health;Utah;virtual reality;Work;Writing

PROJECT_TITLE: Cortical basis of complex motor sequences in humans for neural interfaces


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Veteran surgical patients commonly suffer critical illness, and a high percentage of these patients in the intensive care units incur stress-related injuries to their very vulnerable intestinal lining. These injuries can result in malnutrition, overwhelming bacterial infection, and death. Despite the medical advances of the past few decades, therapies for these stress injuries are, for the most part, conservative, as there is no current pharmacologic therapy available. This proposal explores the use of a new molecule that could potentially prevent injury and loss of the intestinal epithelial cells, and lead to improved outcomes of critically ill Veteran patients.

PI_NAMEs: TURNER, DOUGLAS J (contact)

PROJECT_TERMS: absorption;Acceleration;Address;Adherens Junction;Affect;Apoptosis;Apoptotic;Bacteria;Bacterial Infections;Biological Process;cell injury;Cell Proliferation;Cell Surface Receptors;Cells;Cessation of life;cost;Critical Illness;Cultured Cells;Data;Decontamination;Digestion;Disease;E-Cadherin;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Event;Exclusion;Exposure to;extracellular;Food;Functional disorder;gastrointestinal;gastrointestinal epithelium;gastrointestinal function;Gastrointestinal Injury;Goals;Gut Mucosa;Human;improved;improved outcome;In Vitro;in vivo;Injury;Intensive Care Units;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;Ischemia;IV Fluid;Lead;Ligands;Maintenance;Malnutrition;Measures;Mechanics;Medical;Methods;MicroRNAs;military veteran;Molecular;Mucous Membrane;Mus;novel;novel strategies;Nutrient;Operative Surgical Procedures;Outcome;overexpression;Pathologic;Pathway interactions;Patients;Permeability;pharmacologic;Physiological;preservation;prevent;Proliferating;protein E;Proteins;Publishing;receptor;Recovery;Regulation;repaired;Reperfusion Therapy;Research;response;Rest;Role;Sepsis;Sphingolipids;sphingosine 1-phosphate;SPHK1 enzyme;Stimulus;Stress;Surface;Surgical Injuries;Testing;Therapeutic Effect;Therapeutic Uses;Tight Junctions;Tissues;Tube;Veterans;wasting;Work

PROJECT_TITLE: Barrier Dysfunction in Severe Surgical Diseases

STUDY_SECTION: SURG

STUDY_SECTION_NAME: Surgery[SURG]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed study will establish the feasibility, acceptability and credibility of a novel, live video mind-body program, “Toolkit for Optimal Recovery after Concussions; TOR-C”, aimed at preventing persistent symptoms following uncomplicated mild traumatic brain injury (aka mTBI) among college-age individuals with anxiety. This age group experiences among the highest prevalence of concussions, and up to 40% of these individuals have comorbid anxiety. A brief, tailored mind body program delivered to this high risk population during the window of opportunity of the acute phase has the potential to decrease conversion to costly and challenging-to-treat chronic symptoms of mTBI.

PI_NAMEs: GREENBERG, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;Acute;Adherence;Aftercare;Age;age group;Anxiety;anxiety symptoms;Attention;attentional control;Award;Behavioral;Benchmarking;Brain Concussion;career;career development;Chronic;Chronic Disease;chronic pain;Clinical;Clinical Research;Clinical Trials;Cognitive;college;comorbidity;Complex;concussive symptom;cost;Data Collection;Development;disability;Dizziness;Dose;Educational process of instructing;efficacy trial;Eligibility Determination;Emotional;Enrollment;Environment;Evidence based intervention;Evidence based treatment;experience;Foundations;Fright;Funding;Future;Goals;Headache;Health;Health Services Accessibility;High Prevalence;high risk population;Home;improved;Individual;Injury;injury recovery;innovation;Institution;Intervention;intervention refinement;Interview;Link;Medical;meetings;Memory impairment;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mHealth;Mild Concussions;mild traumatic brain injury;mind body interaction;Mind-Body Intervention;mind/body;Mission;Modeling;multidisciplinary;Musculoskeletal Pain;National Center for Complementary and Integrative Health;neuroimaging;Neurologic;novel;Orthopedics;parenting intervention;patient population;Patient Self-Report;Patients;persistent symptom;Persons;Phase;physical symptom;Placebo Control;Population;Post-Concussion Syndrome;preference;prevent;Prevention;preventive intervention;Procedures;Process;prognostic value;programs;psychologic;Publications;Qualitative Methods;Qualitative Research;Recovery;recruit;Relaxation;Reporting;Research;Research Design;Research Personnel;response;Risk;satisfaction;screening;skills;Sleeplessness;social stigma;Specific qualifier value;statistics;Symptoms;Technology;Testing;therapy development;Time;Training;Training Programs;university student;Work;young adult

PROJECT_TITLE: Live video mind-body treatment to prevent persistent symptoms following mTBI


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Little is known about the molecular, structural, and physiology features of human nociceptors, the neurons responsible for detecting and transmitting pain signals to the brain. The proposed Harvard PRECISION Pain Center will provide fundamentally new insight into the molecules expressed in human nociceptors, how these molecular features correlate with nociceptor activity, and how they interact with the cells and molecules that are present in painful human neuromas that drive phantom limb pain. We envision that the intersection of these data types will have valuable implications for prioritizing new pain therapeutic targets and interpreting how human genetic variation contributes to chronic pain.

PI_NAMEs: RENTHAL, WILLIAM RUSSELL (contact);WOOLF, CLIFFORD J

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Affect;American;Animal Model;Atlases;Autopsy;Biological Assay;Brain;cell type;Cells;central sensitization;Chronic;chronic pain;chronic pain patient;chronic painful condition;clinical translation;Communities;cost effective;Data;data harmonization;Data Set;data sharing;design;effective therapy;Ensure;Erythromelalgia;experience;Explosion;Feedback;Future;Gene Expression Profile;Genes;Genetic;Genetic Variation;Helping to End Addiction Long-term;Human;Human Genetics;human tissue;improved;Individual;Informed Consent;innovation;insight;Investigation;Knowledge;Medicine;meetings;Methods;Mission;Molecular;Monitor;multiple omics;Mus;Neuroglia;Neuroimmune;Neuroma;Neurons;Nociception;Nociceptors;novel;Opioid;opioid use disorder;Pain;Pain Clinics;Pain Free;Pain management;pain model;pain signal;Patients;Peripheral;Peripheral Nerves;Phantom Limb Pain;Phenotype;Physics;Physiological;Physiology;Population;Population Heterogeneity;Positioning Attribute;Process;Productivity;Protocols documentation;Publications;Quality of life;Research;Research Personnel;Sample Size;Sampling;Sensory Ganglia;single cell genomics;single cell technology;skills;Technology;Therapeutic;therapeutic target;tissue processing;Tissue Procurements;Tissue Sample;Tissues;tool;transcriptomics;Translations;transmission process;tumor-immune system interactions;Work

PROJECT_TITLE: Harvard PRECISION Human Pain Center


PI_NAMEs: RENTHAL, WILLIAM RUSSELL (contact)

PROJECT_TERMS: Back;Code;Communication;Complex;Coordination and Collaboration;Data;data dissemination;data sharing;Ensure;Feedback;Fostering;Goals;Hospitals;Human;Leadership;Logistics;medical schools;meetings;Monitor;Occupational activity of managing finances;Office of Administrative Management;Pain;Pain Clinics;Parents;Patients;Process;Progress Reports;Protocols documentation;Reporting;Research Personnel;Safety;Safety Management;Sampling;Schedule;Scientist;Structure;success;symposium;Time;Tissues;tool;United States National Institutes of Health;Update;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Genetics;Human Genome;Neurosciences;Pain Research

PROJECT_TERMS: Affect;Afferent Neurons;Age;Animal Model;Atlases;Autopsy;Capsaicin;Case/Control Studies;Cause of Death;cell type;Cells;chronic pain;chronic pain patient;chronic painful condition;Clinical;Collaborations;Communities;Complement;Complex;cost effective;Data;Data Set;design;Development;Dimensions;druggable target;effective therapy;Elements;Ensure;epigenomics;G-Protein-Coupled Receptors;Ganglia;Gene Delivery;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genetic Transcription;Genetic Variation;genome wide association study;Genotype;Human;human data;Human Genetics;human tissue;Individual;insight;Ion Channel;Location;Maps;Measures;Methods;Mining;Molecular;Multiomic Data;multiple omics;Mus;Neuroglia;Neurons;Nociception;Nociceptors;novel;Pain;Pain Clinics;Pain management;pain model;Pain Research;Physiological;Physiology;Protocols documentation;Regulatory Element;Reporting;Reproducibility;Resolution;Resources;Role;Sample Size;Sampling;Sensory Ganglia;Sex Differences;single cell analysis;single cell genomics;Testing;Therapeutic;therapeutic target;Time;tissue processing;Tissue Procurements;Tissues;tool;transcription factor;transcriptomics;Translations;Untranslated RNA;Variant;Work

PROJECT_TITLE: Project 1: Multi-omic characterization of human nociceptors


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PI_NAMEs: WOOLF, CLIFFORD J (contact)

PROJECT_TERMS: Anatomy;Architecture;Automobile Driving;Axon;axon injury;Binding;biobank;Biochemical Pathway;Blood Vessels;cell type;Cells;chemotherapy;Clinical Data;clinical phenotype;Collection;Communities;comorbidity;Data;Data Collection;Data Set;Data Storage and Retrieval;Development;Development Plans;diabetic;differential expression;Disease;diverse data;Excision;Fibroblasts;Functional disorder;Genetic Transcription;genomic data;genotyped patients;Goals;Histologic;Human;Immune;Immunofluorescence Immunologic;Injury;insight;Knowledge;Ligands;limb amputation;Link;Local Anesthetics;Mechanical Stimulation;Mechanics;Molecular Analysis;Morphology;muscle reinnervation;Nerve;nerve injury;Nerve Tissue;Neuroglia;Neuroma;Neuronal Injury;Neurons;novel;novel therapeutic intervention;novel therapeutics;Pain;Pain Clinics;Pain management;pain reduction;painful neuropathy;Pathologic;Pathway interactions;Patients;Periodicity;Peripheral;Peripheral Nerves;Phenotype;preclinical study;Procedures;Process;protein expression;Proteomics;receptor;regenerative;Research;Sampling;Schwann Cells;sciatic nerve;Signal Pathway;Signaling Molecule;single-cell RNA sequencing;Site;Source;spatial relationship;Stains;Standardization;Stretching;System;Time;tool;Transcript;transcriptomics;Trigeminal nerve structure;tumor growth

PROJECT_TITLE: Project 2: The cell types and states of painful neuromas


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PI_NAMEs: EBERLIN, KYLE  (contact)

PROJECT_TERMS: Agreement;Animal Model;Autopsy;Biological Assay;Biological Markers;Biology;Brain;Cell Nucleus;Cells;Central Nervous System;Chronic;chronic pain patient;chronic painful condition;clinical phenotype;clinical translation;Collaborations;Collection;Data;Databases;design;Distal;Drug or chemical Tissue Distribution;effective therapy;Eligibility Determination;Enrollment;experience;Freezing;Ganglia;General Hospitals;Genetic;Genomics;Goals;Human;human tissue;improved;Individual;Informed Consent;Institutional Review Boards;Knowledge;Left;Massachusetts;Metadata;Molecular;Mus;muscle reinnervation;Nerve;Neuroma;Nociception;Nociceptors;novel;Operative Surgical Procedures;Pain;Pain Clinics;Pain management;pain model;Pain quality;pain score;painful neuropathy;Patients;Peripheral;Phantom Limb;Phantom Limb Pain;Physiology;Positioning Attribute;Process;programs;Protocols documentation;Publishing;Randomized;Reporter;Research Personnel;Resected;Resolution;Resources;Running;Sampling;sciatic nerve;Secondary to;single cell genomics;Source;Spinal Cord;Spinal Ganglia;Structure of trigeminal ganglion;Therapeutic;therapeutic target;Tissue Banks;tissue processing;Tissue Procurements;Tissue Sample;Tissues;tool;Translations;tumor-immune system interactions;Work

PROJECT_TITLE: Human Tissue Procurement and Processing Core


NIH_SPENDING_CATS: Chronic Pain;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

PI_NAMEs: DONG, XIANJUN  (contact)

PROJECT_TERMS: analysis pipeline;analytical method;ATAC-seq;Bioinformatics;bioinformatics pipeline;Biological;Biological Markers;Brain region;cell type;Cells;Chromatin;Clinical;clinical phenotype;cloud based;Communities;cost effective;Data;Data Analyses;data centers;data exchange;data harmonization;data infrastructure;data integration;data management;data portal;Data Security;Data Set;data sharing;Data Storage and Retrieval;Data Store;data submission;Databases;demographics;Diagnosis;differential expression;DNA Sequencing Facility;Enhancers;Ensure;Epigenetic Process;epigenomics;genetic element;genetic variant;Genotype;Guidelines;Helping to End Addiction Long-term;Human;Individual;Learning;Location;Metadata;Methods;Molecular;Multiomic Data;multiple omics;Nature;Neuroma;Pain;Pain Clinics;Pain management;pain score;Pathway interactions;Patients;Physiological;Physiology;power analysis;Process;Quality Control;Reporting;repository;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Secure;Services;single cell ATAC-seq;single-cell RNA sequencing;SNP genotyping;Source Code;Statistical Data Interpretation;Technology;Tissues;tool;Training;transcriptomics;transmission process;United States National Institutes of Health;web interface;web portal

PROJECT_TITLE: Data Core


PROJECT_TERMS: assay development;Back;Benchmarking;Biological Assay;Cell Communication;Cell Nucleus;cell type;Cells;Chromium;chronic pain;Consultations;Core Facility;cost;cost effective;cost effectiveness;Data;data standards;Development;Dissociation;DNA;Drops;Ecosystem;Emergency Situation;Ensure;epigenomics;experience;Freezing;Fresh Tissue;Gene Expression;Genomics;Genotype;High-Throughput Nucleotide Sequencing;Hour;Human;human tissue;improved;Individual;Infrastructure;innovation;Laboratories;Learning;Libraries;member;multi-ethnic;multidisciplinary;multiple omics;next generation sequencing;Output;Pain;Pain Clinics;pain processing;Process;Protocols documentation;Quality Control;Recommendation;Reporting;Research;Research Personnel;Resources;RNA;Sampling;Sensory Ganglia;Services;single cell analysis;single cell genomics;single cell sequencing;Technology;Time;Tissues;tool;Training;transcriptomics;whole genome;XCL1 gene

PROJECT_TITLE: Multi-Omics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Genetics;Human Genome;Neurosciences;Pain Research

PI_NAMEs: MOFFITT, JEFFREY  (contact)

PROJECT_TERMS: Adopted;Algorithms;archived data;Area;Atlases;Bar Codes;Behavior;Brain;cell behavior;Cell Physiology;cell type;Cells;Central Nervous System;Communities;Consultations;cost;Cryoultramicrotomy;Data;Data Analyses;design;Detection;Development;Disease;Dissociation;Emerging Technologies;Equipment;experience;Experimental Designs;Expression Profiling;Fluorescent in Situ Hybridization;Frequencies;Genes;Genome;Goals;Health;High Performance Computing;Home;Human;Image;imaging approach;Immunofluorescence Immunologic;improved;In Situ Hybridization;Individual;innovation;insight;instrumentation;Knowledge;Laboratories;Libraries;Liquid substance;Maps;Measurement;member;Methods;Microscopy;Modality;Modeling;Molecular;Neurologic Process;new technology;Pain;Pain Clinics;Patients;Performance;Positioning Attribute;Preparation;preservation;Production;quality assurance;Quality Control;Research Personnel;Resolution;RNA;RNA Splicing;Running;Sampling;Services;single cell technology;single molecule;single-cell RNA sequencing;Slice;Stains;submicron;Techniques;Technology;technology development;Tissue atlas;tissue preparation;Tissues;Training;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Spatial Core (Moffit)


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LITTLE ROCK

ORG_NAME: MASSIVE ANALYSIS AND QUALITY CONTROL SOC

ORG_STATE: AR

PHR: The MAQC Society seeks to enhance reproducibility, and quality control across high throughput biomedical research. Through the annual society conference, the MAQC Society promotes education, best practices, collaboration, and idea exchange across sectors, training levels, and communities. Educating scientists around the world about ways to enhance the rigorousness of their research will enable more successful translation of research to positively impact patient lives.

PI_NAMEs: KUSKO, REBECCA  (contact)

PROGRAM_OFFICER_NAME: GROVES, ASHLEY

PROJECT_TITLE: Advancing Rigorousness and Reproducibility for High Throughput Data


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative (Relevance) Cancer is the second leading cause of death in the United States and the number of cancer deaths is growing. The increasingly burdensome, unbeneficial care received by cancer patients at the end-of-life has been identified by the National Academy of Medicine as a major public health problem. This application proposes to test powerful psychosocial approaches to reduce the suffering and improve the delivery of cancer care both for the patients with end- stage disease as well as for the family members who love, care for, inherit cancer risk from, and, ultimately, survive them.

PI_NAMEs: PRIGERSON, HOLLY GWEN (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Academy;Address;Advance Care Planning;Award;Behavioral;black patient;cancer care;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;Caregivers;Caring;Cause of Death;Cessation of life;chemotherapy;Clinical;Communication;Data;Decision Making;Disclosure;Disparity;Distress;Effectiveness;Emotional;end of life;end of life care;end of life outcomes;end stage disease;Ensure;Equity;ethnic minority population;Family member;Frequencies;improved;Inferior;Inherited;Intervention;Love;Malignant Neoplasms;Medical;Medicine;Mental Health;Oncologist;Outcome Study;overtreatment;Pain;palliate;palliative chemotherapy;patient prognosis;Patients;Persons;Prognosis;prognostic;psychosocial;psychosocial adjustment;Psychosocial Factor;Public Health;racial minority population;Research;Research Personnel;Resources;Spiritual care;Testing;theories;Treatment/Psychosocial Effects;United States

PROJECT_TITLE: Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE This project will advance public health by developing new CAHPS survey items targeted at underserved groups of the U.S. population, evaluate alternative methods of data collection designed to improve response rates, enhance the collection and analysis of patient narrative reports about health care, and assess the impact of CAHPS surveys and reports on quality improvement efforts and patient experiences with care. We will use a health equity focus to better represent and enhance the experiences of care for traditionally underserved patients: racial/ethnic minorities, those with Spanish-language preference, and those with functional limitations. The products include new targeted items, updates to the standard CAHPS health plan and clinician and groups surveys, information about optimal data collection methods, methods to minimize bias in analyzing patient narrative data, and quality improvement demonstrations that improve patient care and promote equity.

PI_NAMEs: ELLIOTT, MARC ;HAYS, RONALD DALE (contact)

PROGRAM_OFFICER_NAME: BAKDASH, JONATHAN

PROJECT_TITLE: Consumer Assessment of Healthcare Providers and Systems (CAHPS) VI


ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The CAHPS VI team will develop, test, and maintain CAHPS surveys; survey methods and protocols; and analysis programs. In addition, the team will conduct and evaluate quality improvement projects. The study results, surveys, reporting materials, and quality improvement methods will be communicated and promoted to improve patients’ care experiences.

PI_NAMEs: CLEARY, PAUL D (contact);EDGMAN-LEVITAN, SUSAN


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Mitochondria are increasingly being appreciated as regulators of immune signaling, including during age- dependent immune dysfunction. MOTS-c is a peptide encoded within the mitochondrial genome that can regulate nuclear gene expression during age-related metabolic stress to increase lipid metabolism and prevent high-fat diet induced obesity. Here, we will test the effect of MOTS-c on preventing and reversing age-related macrophage maladaptation to lipid stress, which will demonstrate that immunity is encoded in both the nuclear and mitochondrial genomes.

PI_NAMEs: RICE, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Acceleration;Adipose tissue;Age;age related;age related decline;age-related disease;aged;Aging;aging nutrition;Anti-Inflammatory Agents;Atherosclerosis;biological adaptation to stress;Biological Assay;Biological Response Modifiers;Bone Marrow;Cardiovascular Diseases;Cell Death;Cell Nucleus;Cells;Cholesterol;Chronic;chronic inflammatory disease;Circulation;cytokine;Data;Diabetes Mellitus;Diet;diet-induced obesity;Disease Progression;Energy-Generating Resources;Environment;Exhibits;experimental study;Exposure to;Fatty Liver;Fibrosis;Foam Cells;Gene Expression;Gene Expression Profile;Genome;Hepatic;Heterogeneity;High Fat Diet;Homeostasis;Immune;immune function;Immune response;Immune signaling;Immune System Diseases;Immunity;Immunomodulators;Impairment;Inflammation;Inflammatory;inflammatory marker;Innate Immune System;intraperitoneal;LDL Cholesterol Lipoproteins;lipid metabolism;lipidomics;Lipids;Liver;Macrophage;Metabolic;Metabolic dysfunction;Metabolic stress;Mitochondria;Mitochondrial DNA;mitochondrial genome;Monitor;monocyte;Mus;nonalcoholic steatohepatitis;Nonesterified Fatty Acids;Nuclear;old mice;Open Reading Frames;Organelles;Output;Overnutrition;oxidized low density lipoprotein;Peptide Initiation Factors;Peptides;Peritoneal Macrophages;Phenotype;Play;prevent;Process;Production;programs;Property;protective effect;Reactive Oxygen Species;recruit;Regulation;Reporting;Research;response;RNA, ribosomal, 12S;Role;Signal Transduction;single-cell RNA sequencing;Sterility;Stress;Testing;Therapeutic;Tissues;transcriptome;Triglycerides;wound healing

PROJECT_TITLE: Mitochondrial-encoded immunity in restoring macrophage homeostasis under age-related metabolic stress


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ITHACA

ORG_DEPT: BIOLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The number of distinct cell types has been increasing throughout the diversification of animals. Despite recent advances in our ability to characterize the molecular identity of individual cells, understanding the processes that result in the origin of truly novel cell types persists as one of the key challenges in developmental biology. The goal of this research project is to probe the capacity of cells to acquire new functions by manipulating the genes that control cell identity and to use this knowledge to produce a cell type that has never arisen naturally.

PI_NAMEs: BABONIS, LESLIE S (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Behavior;Biological Models;Body System;Cell Lineage;Cell Physiology;cell type;Cells;Characteristics;Cnidaria;coral;Development;Developmental Biology;Drosophila genus;Elements;Environment;Evolution;Gel;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Genes;genetic manipulation;Genomics;Goals;Individual;innovation;Jellyfish;Knowledge;Laboratory Organism;Measurable;Modeling;Molecular;Morphogenesis;Morphology;Mucous body substance;Nematostella;novel;Organism;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Process;Proteins;Regulator Genes;Research;Research Project Grants;Role;Sea Anemones;Secretory Vesicles;segregation;Seminal fluid;Somatic Cell;Source;Sting Injury;Subcellular structure;System;Techniques;Technology;Testing;Tissues;trait;transcription factor;transcriptomics;Translating;Venoms

PROJECT_TITLE: Gene Regulation and the Origin of New Cell Types

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative In biomedical research, the need for a diverse pool of researchers in statistics and data science has never been greater, but the requisite academic pipeline for training such a workforce remains inadequate. SeattleStatSummer (SeattleStatSummer for Biomedical Data Science Research Training) is a summer mentored research program for undergraduate students who identify as underrepresented minorities, and will include an engaging and supportive mentored research experience along with career development, community building, and social/emotional support activities to encourage students to (1) gain skills and confidence in statistics and data science and (2) feel a sense of belonging and rightful place in the statistics and research communities. The goal of SeattleStatSummer will be to promote a diverse workforce to ensure that future biomedical researchers will represent our broader community.

PI_NAMEs: BOBB, JENNIFER FEDER;CHOWNING, JEANNE TING;OTHUS, MEGAN  (contact)

PROJECT_TERMS: Acute;Address;Admission activity;American;Area;Automobile Driving;Awareness;Bachelor's Degree;biomedical data science;Biomedical Research;Biometry;Black race;Cancer Center;care outcomes;career;career development;Code;Communities;community building;community partnership;COVID-19 pandemic;Data Science;Disparity population;Diverse Workforce;Educational workshop;Emotional;Environment;equity, diversity, and inclusion;ethnic minority;experience;Faculty;faculty mentor;Fostering;Foundations;Future;Goals;Graduate Degree;Health;health care availability;health inequalities;Hispanic;Home;Immigrant community;improved;Individual;Institution;interest;Internet;Internships;Leadership;marginalized population;Mentors;Methods;Minority;minority student;Mission;next generation;Participant;Positioning Attribute;Principal Investigator;programs;Psychological reinforcement;Qualifying;racial minority;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;role model;Science;science education;Services;skills;social;sound;statistics;student mentoring;Students;success;summer internship;summer research;Time;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;volunteer;Washington


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative:  Ocular inflammation plays a significant role in vision loss associated with retinal disorders, yet immune cells that facilitate this response are poorly understood due to limitations in imaging these microscopic cells. Using a collection of innovations in high-resolution imaging, this project will image these cells for the first time using a label-free approach combined with fluorescent cell populations to reveal the types and behaviors of immune cells in the living eye as it responds to inflammation.

PI_NAMEs: SCHALLEK, JESSE BARRETT (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;adaptive optics;Affect;Age related macular degeneration;Antigens;Arteries;arteriole;Autoimmune;Autoimmune Diseases;autoimmune uveitis;Behavior;Behavior monitoring;Binding Proteins;Biological Markers;Biopsy;Blindness;Blood capillaries;Blood Cell Count;Blood Cells;Blood flow;blood flow measurement;Blood Vessels;CD4 Positive T Lymphocytes;cell behavior;Cell Communication;Cell Physiology;cell type;Cells;cellular imaging;cellular targeting;clinical application;clinical translation;Collection;contrast imaging;Contrast Media;Diabetic Retinopathy;Diameter;disease model;Edema;Endotoxins;Evolution;Eye;Flow Cytometry;Fluorescence;Geographic Distribution;Glaucoma;high resolution imaging;Histology;Hour;Human;Image;imaging approach;imaging modality;imaging platform;Immune;Immune Cell Suppression;immune imaging;Immune response;Immune system;in vivo;in vivo imaging;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;innovation;insight;interstitial retinol-binding protein;intravitreal injection;Label;Laboratories;Leukocytes;Light;Lipopolysaccharides;Location;Measures;Mediating;meter;Microglia;Microscopic;microscopic imaging;Microscopy;migration;millisecond;Modality;Modeling;Monitor;Mus;Natural History;Nature;neutrophil;non-invasive imaging;novel;novel therapeutics;Ophthalmoscopes;Ophthalmoscopy;Optical Coherence Tomography;optical imaging;Optics;Pathogenicity;Perfusion;perfusion imaging;Pharmacologic Substance;Phase;Play;Population;Proxy;Reporter;Reporting;Research;Resolution;response;Retina;Retinal Diseases;Role;Scanning;sight restoration;Speed;Swelling;T-Lymphocyte;Techniques;Thick;Thinness;time use;Tissues;transcriptome sequencing;treatment response;Uveitis;Vascular System;Veins;venule;Viral;Vision;Visualization;Work

PROJECT_TITLE: Imaging immune cell type and behavior in the living retina using adaptive optics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PHILADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Nucleases are enzymes that degrade nucleic acids in many biological processes. Failures in nuclease activity are attributed to diseases including cancer predisposition syndromes, Huntington’s disease, and infertility. A mechanistic understanding of nuclease regulation and specificity informs models for these diseases and the development of new gene editing tools.

PI_NAMEs: MANHART, CAROL M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Archaea;Area;Bacteria;Biochemistry;Biological Process;Biology;Biotechnology;cancer predisposition;Cell Physiology;Colorectal Cancer;Communication;Complex;Development;Disease;disease model;DNA;DNA biosynthesis;DNA Repair;Endometrial Carcinoma;Enzymes;Failure;Future;gene editing technology;Genetic Recombination;genome integrity;Genus Mycobacterium;Hereditary Nonpolyposis Colorectal Neoplasms;Homologous Gene;homologous recombination;human disease;Huntington Disease;Infertility;insight;interest;Link;Maintenance;Meiotic Recombination;Methods;Mismatch Repair;Modeling;Molecular;Mycobacterium tuberculosis;new therapeutic target;novel;nuclease;Nucleic Acids;Organism;Pathway interactions;Process;programs;Proteins;Regulation;repaired;Research;Site;Specificity;Substrate Specificity;Syndrome;Testing;Therapeutic;Therapeutic Agents;tool;Trinucleotide Repeat Expansion;Tuberculosis;Work

PROJECT_TITLE: Molecular mechanisms of modular nuclease domains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative (Public Health Relevance) Given the rising burden of obesity, diabetes, and heart disease in the community, new approaches are needed to maintain blood vessel health from the impact of cardiometabolic traits. The proposed research investigates the impact of cardiometabolic diseases on health of the blood vessel lining cells, endothelial cells, by measuring stress markers and gene expression pathways. Our results will clarify how cardiometabolic diseases result in different patterns of endothelial cell gene expression and may identify novel molecular underpinnings of cardiovascular risk that will have important preventive and therapeutic implications.

PI_NAMEs: HAMBURG, NAOMI MIRIAM (contact);HO, JENNIFER E

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Acceleration;Adult;Age Distribution;Aging;Atherosclerosis;Automobile Driving;Basic Science;Bioinformatics;Biological;Biology;Biopsy;Blood Vessels;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;case control;Cell Line;Clinical;clinical development;clinical phenotype;cohort;Communities;Data;Development;Diabetes Mellitus;differential expression;Disease;Drug Modulation;Dwarfism;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experience;experimental study;fitness;Framingham Heart Study;Functional disorder;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Genomic approach;genomic biomarker;Glucose;Health;Heart Diseases;Human;Immunofluorescence Immunologic;Individual;innovation;insight;Insulin Resistance;Life;Link;Longitudinal cohort study;Measures;Metabolic;Metabolism;metabolomics;middle age;minimally invasive;Mitochondria;mitochondrial dysfunction;Molecular;multidisciplinary;multiple omics;Nested Case-Control Study;Nitric Oxide;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Obesity associated cardiovascular disease;Organelles;Participant;Pathway Analysis;Pathway interactions;patient oriented research;Pattern;Phenotype;Population Sciences;premature;Prevalence;Preventive;Procedures;programs;prospective;Public Health;public health relevance;Research;Research Personnel;Resources;Risk;Risk Factors;RNA analysis;Sampling;Sex Distribution;Signal Transduction;Stress;Therapeutic;trait;Transcript;transcriptome sequencing;transcriptomics;Vascular Diseases;Vascular Endothelium;vascular injury;Venous;Work

PROJECT_TITLE: Endothelial Cell Health Across the Spectrum of Cardiometabolic Disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: In this proposal, we will develop Spherical Nucleic Acid (SNA) nanoconjugates as a novel class of cGAS- STING pathway agonists. We will evaluate their anti-tumor effect as monotherapy and when combined with existing immunomodulatory approaches to credential SNAs as a novel immunotherapeutic modality for the treatment of malignant brain tumors.

PI_NAMEs: MIRKIN, CHAD A.;STEGH, ALEXANDER H. (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: 3-Dimensional;Activated Natural Killer Cell;adaptive immune response;Adaptor Signaling Protein;Address;Adenosine;Advanced Malignant Neoplasm;Agonist;Animals;Anti-sense DNA;Antigen-Presenting Cells;antitumor effect;Architecture;Binding;Biochemical;Biological;Biological Availability;bioluminescence imaging;Brain;Cancer Model;Cancer Patient;cancer type;Cells;Characteristics;Clinical;clinical application;Clinical Trials;Combined Modality Therapy;Credentialing;CXCL10 gene;Cyclic GMP;Data;delivery vehicle;density;Development;Diagnosis;dimer;Dinucleoside Phosphates;DNA;Dose;ds-DNA;early phase clinical trial;Enzymes;Formulation;Gene Activation;Gene Expression;Generations;Genes;Genetic Engineering;Genetic Transcription;Glioblastoma;Glioma;Histopathology;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;Immunologic Stimulation;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved outcome;In Vitro;in vivo;Infiltration;Inflammatory;Innate Immune Response;innate immune sensing;Interferons;Intranasal Administration;IRF3 gene;Knowledge acquisition;Lead;Libraries;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Modality;Modeling;mouse model;Mus;Myelogenous;Myeloid-derived suppressor cells;nanoarchitecture;Nanoconjugate;nanoGold;nanoparticle;Natural Killer Cells;neuro-oncology;NK Cell Activation;novel;Nuclear;nuclease;nucleic acid structure;nucleic acid-based therapeutics;Nucleic Acids;Nucleosome Core Particle;Oligonucleotides;Pathway interactions;Patients;PD-1 inhibitors;Periodicity;personalized immunotherapy;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;Phenotype;Production;Property;Radial;Research;response;sensor;Signal Transduction;Small Interfering RNA;small molecule;Solid;Solid Neoplasm;Spherical Nucleic Acids;Stimulator of Interferon Genes;Structure;Surface;Survival Analysis;T-Lymphocyte;Testing;TLR9 gene;Toll-like receptors;Toxic effect;Transcriptional Activation;Treatment Protocols;tumor;tumor growth;Tumor-Derived;uptake;Vaccines

PROJECT_TITLE: Spherical Nucleic Acid nano-architectures as first-in-class cGAS agonists for the immunotherapeutic treatment of Glioblastoma.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Alzheimer’s Disease (AD) is the leading cause of dementia in the elderly. Two major pathological hallmarks are amyloid β plaques accumulation outside of cells and phosphorylated tau tangles within the neurons. Understanding the crosstalk between these two pathologies allows for better capture of the timing of disease development and is crucial for the development of therapeutic targets for AD.

PI_NAMEs: TRAN, KRISTINE MINH (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Acceleration;Affect;Affinity;Age Months;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Anxiety;apolipoprotein E-3;Behavior assessment;behavior test;behavioral outcome;beta amyloid pathology;Binding;Brain;Case Study;Cells;cerebral atrophy;Chronic;Clinical;clinical phenotype;Cognitive;Cognitive deficits;Dementia;Development;Disease;Disease Outcome;Elderly;Exhibits;extracellular;familial Alzheimer disease;Fluorescent in Situ Hybridization;genetic risk factor;Heparan Sulfate Proteoglycan;Human;hyperphosphorylated tau;Immune response;Immunohistochemistry;Immunotherapy;Impaired cognition;Impairment;improved;Inflammation;insight;Investigation;Knock-out;Link;Lipoprotein Receptor;MAPT gene;Microglia;Motor;motor behavior;motor deficit;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neuroprotection;neurotoxic;novel;older adult;Onset of illness;Pathologic;Pathology;Phenotype;presenilin-1;prevent;protective effect;Protein Analysis;protein function;rare variant;receptor binding;Reporting;Resistance;response;Role;Senile Plaques;Symptoms;tau aggregation;tau Proteins;tau-1;Tauopathies;therapeutic development;therapeutic target;Time;transcriptome sequencing;transcriptomics;uptake;Variant

PROJECT_TITLE: Determining the mechanisms of the protective APOE3ch variant on Alzheimer's Disease pathologies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Learning complex skills such as speech or musical performance requires trial and error motor “exploration” coupled with reinforcement of “better” outcomes. This proposal seeks to build predictive models of how the brain enables variations in behavioral performance to be generated and selectively reinforced to enable complex motor learning.

PI_NAMEs: GARDNER, TIMOTHY JAMES;LOIS, CARLOS ;MOONEY, RICHARD D (contact);PEARSON, JOHN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Acute;Adolescent;Affect;Animal Vocalization;Animals;Athletic;Auditory area;autoencoder;Basal Ganglia;Behavior;Behavior Therapy;Behavioral;Brain;calcium indicator;cell type;Cells;Complex;Computer Models;Corpus striatum structure;Coupled;Dedications;density;Elements;experimental study;Fiber;flexibility;Freedom;Frequencies;Geometry;Goals;Head;high dimensionality;high resolution imaging;Hour;imaging modality;Injections;Learning;Learning Skill;Link;Maintenance;Maps;Measures;Methods;Microscope;Modeling;Monitor;Motor;Motor Cortex;motor learning;Movement;Music;neural;neural patterning;neuromechanism;Neurons;Noise;novel;Optics;optogenetics;Outcome;Pattern;Performance;Population;predictive modeling;Psychological reinforcement;Resolution;response;Signal Transduction;skills;Source;Speech;System;Testing;theories;Update;Variant;vocal learning;vocalization

PROJECT_TITLE: Corticostriatal contributions to motor exploration and reinforcement


ORG_NAME: HEALTH RESOURCES IN ACTION, INC.

PHR: Project Narrative Even though data science and STEM careers offer financial stability, youth who identify as Black, Latinx, women, low-income, or first-generation college students face systemic barriers to pursuing these careers. The proposed project will address this workforce issue by attracting and supporting a diverse group of top science students from Boston, Cambridge, and Everett, Massachusetts high schools with large Black and/or Hispanic enrollment who will be engaged, supported, and encouraged to grow their interest in data science and STEM through a two-year, multi-industry partnership that provides high-level experiential learning opportunities in data science. Combining paid data science internship opportunities and mentorship with college access and persistence, career readiness, and social-emotional learning programming will enable youth to access the financial stability associated with a booming STEM industry without leaving the city where they grew up, while also supporting local industry with a more diverse and well-prepared applicant pool.

PI_NAMEs: MUELLER, KRISTEN LAURA;ORTEGA, DAISY P (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Active Learning;Applied Skills;Area;Bioinformatics;Black race;Boston;career;Career Exploration;career preparation;Cities;Code;college;College Preparation;Communication;Communities;Data Analyses;Data Science;data visualization;design;Educational workshop;Enrollment;Event;experience;Face;First Generation College Students;Grant;high school;High School Student;Hispanic;Industry;industry partner;Institution;interest;Internships;Knowledge;Latinx;Leadership;Learning;Low income;Massachusetts;Mentors;Mentorship;Methods;Modeling;Outcome;Participant;Persons;programs;Public Speaking;Research;Scholarship;Schools;Science;science teacher;Science, Technology, Engineering and Mathematics;Scientist;skills;social emotional learning;statistics;STEM career;STEM field;Students;success;systemic barrier;Time Management;Training;Underrepresented Students;United States;Visit;Woman;Work;Youth

PROJECT_TITLE: Knox Scholars Data Science Research Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project narrative: Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) is a new technology to quantify RNA epigenetics modification. This proposal aims to develop a series of novel statistical methods for MeRIP-seq data preprocessing and analyses, including data normalization, RNA methylation site detection and comparison, and signal deconvolution for data from complex tissues. The methods will be implemented in open source software tools to benefit the genomics community.

PI_NAMEs: QIN, ZHAOHUI ;WU, ZHIJIN JEAN (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Basic Science;Biological;Biological Markers;Biological Process;bisulfite sequencing;Brain;Brain region;cell type;Cells;Characteristics;ChIP-seq;Clinical;Clinical Research;Communities;Complex;complex data;Computer software;computerized tools;crosslink;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Data Analytics;data modeling;Detection;Development;Disease;DNA Methylation;Epigenetic Process;epigenetic regulation;epigenomics;epitranscriptomics;experience;Face;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genomic Segment;Genomics;Heterogeneity;high throughput technology;histone modification;human disease;Immunoprecipitation;improved;Individual;infancy;interest;Joints;Measurement;Messenger RNA;Methodology;Methods;Methylation;Modeling;Modification;Molecular;Morphologic artifacts;Names;Nervous System Disorder;neurodevelopment;neuropsychiatric disorder;new technology;novel;open source;Play;Post-Transcriptional Regulation;posttranscriptional;Preparation;Procedures;Regulation;Research;research and development;Ribonucleosides;ribosome profiling;RNA;RNA immunoprecipitation sequencing;RNA methylation;Role;Sampling;Scientist;Series;Signal Transduction;Site;software development;Software Tools;Source;Statistical Methods;Statistical Models;Structure;Technology;therapeutic target;Tissue Sample;Tissues;tool;transcriptome;transcriptome sequencing;Variant

PROJECT_TITLE: Dissecting epitranscriptomic signal from complex tissues

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE The basal amygdala (BA) is important for valence-specific behaviors such as the recall of aversive memories. Understanding learning and memory associated with the BA is especially important considering how dysregulation of tightly regulated emotional behaviors and associations can contribute to anxiety, depression, and PTSD. This proposal aims to dissect the role of novel projection-defined subregions within the BA in the retrieval of fear and extinction memories, which will provide valuable insights into BA spatial and functional organization.

PI_NAMEs: ZAMUDIO, FRANK  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TITLE: Role of novel projection-defined basal amygdala subregions in fear memory expression


ORG_CITY: RICHMOND

ORG_DEPT: NEUROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Drugs may help the sensory part of chronic pain and the anxiety and depression that follow, but they do not address its core emotional, cognitive and behavioral roots, which require a biobehavioral approach, typically foreign to most primary care practitioners (PCPs). Our prior work showed that PCPs skillfully appropriate and implement this approach with 4PCP, a training program for PCP's to manage chronic pain effectively, resulting in greater work satisfaction and improved patient outcomes. Here we propose to train 27 practices in 4 cities using an intensive, codified and dissemination-ready version of the training and measure whether over the ensuing 2 years: (1) patients have less pain and (2) PCP's are happier with their work, and (3) fewer opioids are prescribed.

PI_NAMEs: CHELIMSKY, THOMAS C. (contact)

PROGRAM_OFFICER_NAME: KATO, ELISABETH

PROJECT_TITLE: Impact of a Novel Community-Based Biobehavioral Chronic Pain Team Training Program (4PCP) on Practitioner and Patient Outcomes

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: RIVERSIDE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative  Memory deficits resulting from temporal lobe epilepsy are often left untreated due to the lack of knowledge regarding underlying mechanisms. This proposal aims to provide novel insights into mechanisms of dentate pattern separation by identifying the contribution of semilunar granule cell (SGC) to inhibition and information processing in normal and epileptic dentate circuits. Understanding fundamental mechanisms of dentate information processing and how they are altered in epilepsy will enable development of therapies to treat memory deficits in epilepsy.

PI_NAMEs: HUANG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Affect;Axon;cell assembly;Cell Death;cell type;Cells;Code;Cognitive deficits;comorbidity;connectome;Data;Dendrites;dentate gyrus;designer receptors exclusively activated by designer drugs;Distal;Epilepsy;Epileptogenesis;excitatory neuron;Exhibits;Failure;Feedback;Fire - disasters;Generations;Genetic Suppression;Glutamates;granule cell;Hilar;Hippocampus;Impaired cognition;Impairment;in silico;Individual;information processing;Injections;insight;Interneurons;Knowledge;Left;Mediating;Mediator;Memory;Memory impairment;Modeling;Molecular;Mus;nerve supply;network models;neural;neural correlate;neurochemistry;Neurons;novel;novel strategies;Optics;optogenetics;Output;Parvalbumins;Patients;Pattern;Physiology;Pilocarpine;Predisposition;Probability;Process;receptive field;Regulation;Role;Saline;Signal Transduction;Slice;Somatostatin;Source;spatiotemporal;Status Epilepticus;Stimulus;Structure;Synapses;Synaptic plasticity;Temporal Lobe Epilepsy;Testing;therapy development;Training

PROJECT_TITLE: Cellular Mediators of Dentate Pattern Separation in Epilepsy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Data Science;Genetics;Neurosciences;Rare Diseases

PHR: Narrative Human brain tumors are genomic heterogeneous within the tumor population and very large datasets of clinical and molecular data on large numbers of patients have been created. Over the past 25 years, my laboratory has worked on modeling brain tumors in mice and correlating those findings with data from human brain tumor patients and have developed unique big data visualization tools that allow the interactive interpretation of these data. We are now using our mouse modeling technology to understand the biology of rare tumors driven by gene fusions and the role of RNA splicing variants of TrkB in development and oncogenesis.

PI_NAMEs: HOLLAND, ERIC C. (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;Adult;Alternative Splicing;Big Data;Biological Models;Biology;Brain Neoplasms;Clinical;Data;Data Analyses;Development;Diagnostic;Disease;Embryo;Embryonic Development;Ependymoma;FDA approved;Gene Fusion;Genetically Engineered Mouse;Genomics;Glioma;Grant;Human;human data;improved;Laboratories;large datasets;Malignant Neoplasms;meningioma;Microtus;Modeling;Molecular;mouse model;Mus;Patients;Pharmaceutical Preparations;Population;rare cancer;RNA Splicing;Role;Technology;Testing;Therapeutic;Therapeutic Studies;therapeutic target;Tissues;treatment response;tumor;tumorigenesis;Variant;Visualization software;Work

PROJECT_TITLE: The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This proposal aims to understand the evolutionary tradeoff between bacterial fitness and phage intracellular competitiveness against other phages when multiple phages infect the same cell. Many clinically relevant bacterial pathogens, including Pseudomonas aeruginosa, carry phages in their chromosome which influences the phenotype and fitness of the bacteria. Understanding this tradeoff will not only be relevant for phage therapy but exploitation of this tradeoff to lower bacterial fitness can potentially make bacterial infections easier to treat.

PI_NAMEs: KUBOTA, NANAMI  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acute;acute infection;Affect;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Chromosomes;bacterial fitness;Bacterial Infections;Bacteriophages;Binding;Biological Models;Capsid;Capsid Proteins;Cells;Characteristics;Charge;Chromosomes;Chronic;Clinical;clinically relevant;clinically significant;Collection;cost;cystic fibrosis patients;Cytolysis;Data;Drug Tolerance;Environment;Evolution;Family;Filament;fitness;Funding;Genes;Genome;Goals;Growth;Human;improved;Infection;Inoviridae;Inovirus;insight;Learning;Length;Longitudinal Studies;Measurement;Measures;Metadata;Microbial Biofilms;Modeling;mutant;Mutation;novel;novel strategies;Parasites;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pharmaceutical Preparations;Phenotype;Population;pressure;Prevalence;prevent;Production;Prophages;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pyocyanine;pyoverdin;Recording of previous events;Reporting;reproductive;Resources;superinfection;Testing;Time;Viral Genome;Viral Proteins;Virulence;Virulence Factors;whole genome

PROJECT_TITLE: Exploiting Pf phage superinfection to lower Pseudomonas aeruginosa virulence via evolutionary tradeoffs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-F(20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PHARMACOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE While AD pathogenesis is still poorly understood, genetic studies have clearly indicated a causal role for microglia, the innate immune cells of the CNS. This project will investigate the effects of competitive inhibition of CD33, a genetically-associated risk factor for Late- Onset Alzheimer’s disease, by sialic acid binding peptides on downstream microglial function in an in vitro model of human AD. This proposal will provide insights to not only the mechanism of action of these peptides, but to also help to clarify the role of CD33 in microglial activation and immune signaling pathways in the progression of Alzheimer’s disease and further development of CD33 targeted therapies.

PI_NAMEs: GREEN, JENNIFER LEIGH (contact)

PROJECT_TERMS: abeta accumulation;Affinity;Alanine;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;amyloid pathology;Binding;Binding Proteins;Biological Assay;Brain;Cells;design;Development;Disease Progression;experimental study;Gene Expression;Genes;genetic association;genetic risk factor;Genetic study;genome wide association study;Genotype;glial activation;Glycoproteins;Human;human model;human old age (65+);Immune;Immune signaling;Immunoprecipitation;Impaired cognition;improved;In Vitro;in vitro Model;in vivo imaging;Individual;Inflammatory;inhibitor;insight;Investigation;Late Onset Alzheimer Disease;Length;Ligands;Measures;Mediating;Methods;Microglia;Molecular;monocyte;Morphology;Myeloid Cells;Neurodegenerative Disorders;neuron loss;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peptides;Phase;Phosphoric Monoester Hydrolases;Predisposition;Process;Property;protein expression;Protein Isoforms;Proteins;PTPRC gene;receptor;response;Risk;Risk Factors;risk variant;Role;Senile Plaques;sialic acid binding Ig-like lectin;sialic acid receptor;Sialic Acids;Signal Pathway;Signal Transduction;Solid;Specificity;Structure;Surface;targeted treatment;tau Proteins;Testing;Thick;TREM2 gene;uptake;Western Blotting

PROJECT_TITLE: Inhibition of CD33-sialic acid binding in Late-Onset Alzheimer's Disease


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE Tumor cells invariably have defects in the biochemical mechanisms that regulate cell growth and division, so understanding how these processes work is vital to understanding and inhibiting cancer. This research is determining a molecular picture of how proteins control normal and cancer cell proliferation.

PI_NAMEs: RUBIN, SETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemical;Biological Assay;cancer cell;Cell Cycle;Cell Cycle Regulation;Cell division;cell growth;Cell Proliferation;Cells;Chromatin;Chromatin Structure;Complex;Defect;DNA biosynthesis;FOXM1 gene;Gene Expression;Genetic Transcription;Growth;improved;inhibitor;innovation;insight;Malignant Neoplasms;Mitosis;Molecular;neoplastic cell;Normal Cell;Pathway interactions;Phosphorylation;Phosphotransferases;Process;Proteins;Regulation;Research;structural biology;Structure;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Molecular Mechanisms of Cell Cycle Dependent Gene Expression

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Many human diseases are driven by errors during cell division. The goal of this project is to understand how the cell replication process affects gene expression and cell identity. Our long- term goal is to better understand genetic diseases like bone marrow failure and cancer by studying how the replication machinery enforces cell identity.

PI_NAMEs: VOLK, ANDREW  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Automobile Driving;Binding;Bone marrow failure;Cell Cycle;Cell Differentiation process;Cell division;Cells;Chromatin;chromatin assembly factor I;Chromatin Modeling;chromatin protein;Complex;Differentiated Gene;Disease;DNA;DNA replication fork;Enhancers;Epigenetic Process;Floods;Gene Activation;Gene Expression;gene repression;Genes;Genetic Diseases;Genetic Transcription;Goals;Histone H3;Homeostasis;human disease;Knowledge;Link;Malignant Neoplasms;Modeling;Mutate;novel;Phenotype;promoter;protein complex;recruit;Replication-Associated Process;Reporting;Repression;Role;S phase;stem cells;Tissues;tool;transcription factor;Transcription Repressor;Transcriptional Regulation;Up-Regulation

PROJECT_TITLE: How CHAF1B maintains cell state by repressing transcription of fate genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: The goal of this project is to examine neural circuit mechanisms involving the retrosplenial cortex that facilitate spatial cognition and episodic memory. The proposed experiments will directly examine circuit flexibility, functional projection patterns, and input-output transformations between retrosplenial cortex, sensorimotor cortex, and the hippocampal formation. These studies will characterize and test dynamics amongst these regions in support of navigation and mnemonic processing while revealing network interactions that may be impaired in pathological states such as Alzheimer’s disease.

PI_NAMEs: ALEXANDER, ANDREW S. (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Anatomy;Animals;Area;Autobiography;Award;base;Behavior;Behavioral;career;Cells;Code;Cognition;Cognition Disorders;cognitive process;density;dimension reduction;Disorientation;Disparate;Electrodes;Environment;Episodic memory;Exhibits;experience;experimental study;extracellular;Faculty;flexibility;Functional disorder;Goals;Hippocampal Formation;Image;Impaired cognition;Impairment;in vivo;in vivo calcium imaging;in vivo imaging;innovation;insight;Knowledge;Laboratories;Learning;Location;Maps;Mediating;Memory;Memory impairment;Mentors;Methods;Modality;Modeling;Motor;Motor Cortex;Neocortex;neocortical;neural circuit;neuroimaging;Neurons;neurophysiology;Neurosciences;optogenetics;Organ;Output;Pathologic;Pattern;Performance;Phase;Population;Positioning Attribute;Process;programs;Property;receptive field;recruit;Research;Research Personnel;response;Role;Sensory;Signal Transduction;Silicon;spatial memory;Stimulus;Stream;success;System;Techniques;Testing;tool;transmission process;way finding

PROJECT_TITLE: Retrosplenial Cortex Circuit Interactions Supporting Spatial Cognition and Memory

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: PROJECT NARRATIVE The CDU-CRECD Mentored Postdoctoral Training in the Science of Minority Health and Health Disparities Program at Charles R. Drew University (CDU) is a mentored clinical research and career development program designed to develop a diverse cadre of clinical and translational investigators who conduct innovative research on the underlying causes of diseases that disproportionately impact minority populations in the United States.

PI_NAMEs: VARGAS, ROBERTO BALBINO (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Achievement;Aging;Area;Award;Back;Cancer Center;career;Career Choice;career development;Clinical;Clinical Investigator;Clinical Research;clinical translation;Communities;community based participatory research;community based research;community engaged research;community partners;Counseling;design;Development;Discipline of Nursing;Disease;Disparity population;disparity reduction;Doctor's Degree;education research;Educational Curriculum;Elderly;empowerment;epidemiology study;ethnic disparity;Evidence based treatment;experience;Faculty;faculty community;faculty mentor;Funding;Goals;Grant;Health;health care service organization;health disparity;Health Professional;implementation facilitation;improve minority health;improved;Individual;innovation;Interdisciplinary Study;Master of Public Health;Measures;Medical;Medicine;Mentors;Mentorship;Methods;Minority;minority communities;minority disparity;Minority Groups;minority health;minority health disparity;Modeling;Outcome;Participant;Pathway interactions;Pharmacy facility;Physician Assistants;Population Heterogeneity;post-doctoral training;prevention practice;Program Development;programs;Quality of Care;racial disparity;racial minority population;Recording of previous events;recruit;Reduce health disparities;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Scholarship;Science;Scientist;senior faculty;Series;social health determinants;Structure;synergism;System;Time;Training;Training and Education;Training and Infrastructure;Training Programs;Translational Research;translational scientist;underserved minority;Underserved Population;United States;Universities;urban health disparities;Work

PROJECT_TITLE: The CDU-Clinical Research Education and Career Development Program


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Young, black men who have sex with men in the US are disparately impacted by HIV, and there is an urgent need for interventions that support these men in HIV treatment, especially those who drink heavily. The proposed project will develop an intervention that leverages social network support and electronic mobile technology to reduce alcohol use and improve HIV treatment outcomes that will then be evaluated against a randomized control condition in a pilot trial among 60 young, black men who have sex with men in an HIV clinic in New York City. The project aims to reduce disparities in HIV treatment outcomes and, in turn, incidence of new HIV infections, a high research priority of the NIH Office of AIDS Research, and an important step towards achieving End the HIV Epidemic milestones.

PI_NAMEs: KNOX, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Adherence;Adoption;Age;Alcohol consumption;Alcohols;Behavior Therapy;black men who have sex with men;brief intervention;career development;Caring;Cellular Phone;Clinic;Continuity of Patient Care;Data;design;Development;Development Plans;disparity reduction;drinking;Drug usage;Educational workshop;effective intervention;effectiveness/implementation trial;efficacious intervention;efficacy evaluation;Electronics;Epidemic;evidence base;Focus Groups;follow-up;forgetting;Goals;Health;Heavy Drinking;HIV;HIV disparities;HIV Infections;HIV Seropositivity;HIV/AIDS;implementation evaluation;implementation intervention;implementation science;improved;Incidence;informant;innovation;Intervention;intervention delivery;Intervention Studies;Interview;Knowledge;Measures;member;men;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;mHealth;mhealth interventions;mobile computing;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;multidisciplinary;New York City;NIH Office of AIDS Research;Outcome;outcome disparities;patient engagement;Persons;Pharmaceutical Preparations;pilot test;pilot trial;primary outcome;Process;process evaluation;programs;Provider;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reduced alcohol use;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;retention rate;Risk;satisfaction;secondary analysis;sexual minority;skills;Social Network;social network intervention;Social support;support network;symposium;Technology;theories;therapy development;Time;Training;training project;transmission process;Treatment outcome;Underserved Population;Viral;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Intervening to improve HIV treatment and reduce drinking in young, black men who have sex with men

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: Westford

ORG_NAME: AMERICAN PHYSICIANS SCIENTISTS ASSN

PHR: APSA ANNUAL MEETING PROJECT NARRATIVE Despite the importance of physician-scientists as critical components of the medical research enterprise and the NIH initiatives put in place to preserve this rarified group, the decline of physician-scientists in the United States remains a major concern. The APSA Annual Meeting directly supports the future of physician-scientists in the United States by providing current trainees with an unparalleled perspective on the career opportunities available to them and by providing numerous opportunities for vertical and horizontal mentorship. This application specifically seeks funds to enhance diversity at this meeting.

PI_NAMEs: KAZMIERCZAK, BARBARA I (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Address;Age;Aging;American;Applications Grants;Award;Biomedical Research;career;career development;Clinical;clinical investigation;Clinical Medicine;Communities;community building;Community Physician;cost;Country;Development;Disabled Persons;disadvantaged background;Doctor of Philosophy;Environment;Ethnic Population;Event;experience;Faculty;Fostering;Functional disorder;Funding;Future;Goals;Health;human disease;Individual;Institution;Medical Research;Medicine;meetings;member;Mentors;Mentorship;Mission;Modality;Participant;Patient Care;Phase;Physicians;Positioning Attribute;preservation;racial population;recruit;Reporting;Research;resilience;Resource Development;Resources;Role;role model;Science;Scientist;Services;Societies;Structure;success;symposium;Time;Training;Travel;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Woman;working group

PROJECT_TITLE: American Physician Scientists Association Annual Meeting

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE People with HIV (PWH) disproportionately experience neurocognitive impairment and psychiatric and medical comorbidities, placing them at greater risk for functional decline in older age. Addressing this public health concern in a rapidly aging population, the proposed study aims to develop a risk index for functional decline in middle-aged and older PWH using adverse and protective factors. Identifying both adverse and protective factors for functional decline in two large, longitudinal datasets of PWH is novel and will contribute to scientific communities and clinical practice by informing prevention and intervention research.

PI_NAMEs: HAM, LILLIAN  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adult;Adverse event;adverse outcome;Age;age effect;Aging;aging population;antiretroviral therapy;behavior measurement;Behavioral;Biological;biopsychosocial factor;Buffers;burden of illness;California;career development;Characteristics;Clinical;clinical practice;Clinical Research;Cognition;Cognitive aging;Communities;Community Practice;comorbidity;Complex;Cross-Sectional Studies;Data;Data Set;Dedications;Development;Development Plans;Diabetes Mellitus;Dimensions;disability;Disease;Emotional;Exhibits;experience;Fostering;functional decline;functional independence;high risk;HIV;HIV anti-retroviral;HIV Seronegativity;human old age (65+);Hyperlipidemia;improved;Incidence;indexing;Individual;individualized prevention;Intercept;Intervention Studies;Knowledge;longitudinal dataset;Longitudinal Studies;Maintenance;Measures;Medical;Mental Depression;Mentors;Mentorship;middle age;Mission;Modeling;National Institute on Aging;neurobehavioral;Neurocognitive Deficit;NIH Office of AIDS Research;novel;older adult;Older Population;Outcome;Pattern;peer;Persons;Population;predictive modeling;preservation;Prevention Research;Prevention strategy;programs;protective factors;psychologic;Psychological Factors;Public Health;Research;research and development;Research Priority;Risk;Role;Sampling;Scientist;skills;social;super ager;Time;tool;tool development;Training;Unemployment;Universities;Validation;Variant;Work

PROJECT_TITLE: Developing a Risk Index for Functional Decline in Middle-Aged and Older Adults with HIV


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alzheimer’s disease is a severely debilitating neurodegenerative disease, marked in early stages by synaptic deficits thought to be caused by the amyloid-β peptide. Down syndrome, a developmental disorder caused by trisomy of chromosome 21, is also marked by synaptic deficits as well as an overabundance of the amyloid precursor protein (APP). This proposal will explore the role of APP in mediation of amyloid-β impairment of CaMKII, an extremely abundant neuronal protein known to play a vital role in mediating synaptic plasticity, and the results of these experiments will provide critical insight into the role APP plays in mediating synaptic impairments in both Alzheimer’s disease and Down syndrome.

PI_NAMEs: LARSEN, MATTHEW E (contact)

PROJECT_TERMS: abeta oligomer;Abeta synthesis;Affinity;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;APLP1 gene;Automobile Driving;Binding;calmodulin-dependent protein kinase II;Cells;Chemicals;Chromosome 21;Cognition;Defect;Dementia;desensitization;developmental disease;developmental genetics;Dose;Down's Syndrome;Elements;Excitatory Synapse;experimental study;extracellular;Future;Gene Proteins;Genetic;Glutamate Receptor;Hippocampus;impaired driving performance;Impairment;Incubated;Individual;insight;knock-down;Knock-out;Knockout Mice;Learning;Light;Long-Term Potentiation;Mediating;Mediation;Mediator;Membrane Proteins;Memory;Memory impairment;Modeling;Movement;Mus;mutant;N-Methylaspartate;Nature;Neurodegenerative Disorders;Neurons;Outcome;overexpression;Peptides;Play;Population;prevent;Process;protein expression;Protein Precursors;Proteins;response;Role;Signal Transduction;Slice;Stimulus;Synapses;synaptic function;Synaptic plasticity;Tertiary Protein Structure;Testing;trafficking;Trisomy

PROJECT_TITLE: APP as a mediator of amyloid beta effects on CaMKII synaptic functions


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Lung

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Multiciliated cells (multiple cilia per cell, MCCs) line the mucociliary epithelium of our airway and are critical to propel mucus out of our body. Defects in morphogenesis of MCCs can lead to an array of respiratory diseases, yet the underlying cellular and molecular mechanisms remain elusive. We have demonstrated that mechanotransduction plays a critical role in MCC morphogenesis and our proposed research will uncover new mechanochemical pathways essential in regulating the differentiation and development of MCCs.

PI_NAMEs: KULKARNI, SAURABH S (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Apical;Architecture;Area;Biomechanics;Breathing;Calibration;Cells;Centrioles;Cilia;Defect;Development;Embryo;Epithelium;fluid flow;Genes;Goals;Impairment;in vivo Model;Individual;Inhalation;Ion Channel;Lung;mechanical force;Mechanics;mechanotransduction;Molecular;Morphogenesis;Mucociliary Clearance;Mucous body substance;Organelles;Outcome;pathogen;Pathologic;Pathway interactions;Piezo 1 ion channel;Play;prevent;Process;Property;Research;Respiratory Disease;Role;System;Time;Tissues;Toxin;Work;Xenopus

PROJECT_TITLE: Mechanotransduction in morphogenesis of mucociliary epithelium and multiciliated cells


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative There is increasing concern that civilian populations might be exposed to chemical toxicants. The primary objective of the Rutgers CounterACT Center of Excellence is to develop medical countermeasures against chemicals threats. A team of researchers has been assembled capable of rapid advancement of candidate drugs through the regulatory process so that they can be used to enhance the medical response capabilities of the United States.

PI_NAMEs: LASKIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Advanced Development;Animal Model;Anti-Inflammatory Agents;Antibodies;Area;Basic Science;Centers of Research Excellence;chemical release;chemical threat;Chemical Weapons;Chemicals;Clinical;Clinical Trials;Collaborations;Cornea;Corneal Injury;Development;Dexamethasone;Disease;drug candidate;drug development;drug discovery;Drug Kinetics;drug repurposing;education research;Effectiveness;efficacy evaluation;Emergency Situation;Event;exposed human population;Exposure to;Eye Injuries;FDA approved;Formulation;Funding;Generations;Goals;Grant;Human;improved;Inhalation;Injury;innovation;Lead;lead candidate;lead optimization;Lung;lung injury;Mechlorethamine;Medical;medical countermeasure;meetings;Military Personnel;Miniature Swine;model development;Modeling;Morbidity - disease rate;mortality;Mustard;Mustard Gas;novel;novel therapeutics;Ointments;Organ;Oxytetracycline;Pathogenesis;Pathology;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Poisoning;Population;Postdoctoral Fellow;pre-Investigational New Drug meeting;Process;Productivity;programs;Rattus;Research;research and development;Research Personnel;response;Rodent;skills;Skin;Skin injury;Students;System;Testing;Therapeutic Intervention;Therapeutic Uses;Tissues;TNF gene;Toxic effect;toxicant;Toxicology;Training;translational model;United States;United States National Institutes of Health;Universities;vapor;Vesicants;Work;Workforce Development;World War I

PROJECT_TITLE: Rutgers University CounterACT Center of Excellence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures

PROJECT_TERMS: Address;Administrator;Advanced Development;Advisory Committees;Awareness;Businesses;Center for Translational Science Activities;Centers of Research Excellence;chemical threat;Clinical Sciences;Communication;data management;Doctor of Philosophy;drug development;Education;education research;Ensure;Environment;Evaluation;Goals;Grant;Health;Human Resources;Institution;Intellectual Property;Legal patent;Licensing;medical schools;member;Mentors;Mission;Mustard;New York;operation;Process Assessment;Productivity;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Scientist;success;Sum;synergism;therapeutic candidate;Toxicology;Training;training opportunity;Universities;Vesicants

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-B]


ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: The burden of COVID-19 on survivors and health care systems is greater than we imagined. Most Veterans recover from the illness, but a considerable number have lingering symptoms that affect mental health and sleep. Cognitive problems are commonly reported in post-acute COVID-19, with a substantial impact on social and occupational function. Yet self-reported “brain fog” appears to be an under- investigated outcome. A distinct gap in the literature to date is objective cognitive testing in Veterans who had a positive test for COVID-19. The current project will use a web-based platform to directly assess cognitive function over time and its relationship to mental health in COVID survivors. Determining which factors are most associated with the negative consequences of compromised cognitive function post- COVID is a critical question not yet addressed by current studies. The results will have important implications for Veterans and the VA, especially since new variants of the virus will appear in the future.

PI_NAMEs: SWICK, DIANE  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Anxiety;Anxiety Disorders;associated symptom;brain fog;breakthrough infection;Cardiovascular system;Caring;Cognitive;cognitive function;cognitive performance;cognitive testing;Commerce;Communities;comorbidity;comparison control;comparison group;COVID-19;COVID-19 burden;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 survivors;COVID-19 test;daily functioning;design;Development;Diabetes Mellitus;Diagnosis;Disease;Education;Employment;epidemiology study;Episodic memory;executive function;Fatigue;follow-up;Follow-Up Studies;Future;Health;Healthcare Systems;Heart Diseases;Hypertension;Impaired cognition;Impairment;improved;Individual;Infection;Intervention;Investigation;Literature;Long COVID;long term consequences of COVID-19;Measures;Mental Depression;Mental Health;Metabolic Diseases;military veteran;Minority;Modeling;Monitor;neurocognitive disorder;Observational Study;Occupational;Online Systems;Outcome;Outcome Measure;pandemic disease;Participant;Patient Self-Report;Patients;Performance;persistent symptom;Persons;Phase;physical symptom;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID conditions;post-COVID-19;Post-Traumatic Stress Disorders;Printing;Process;prospective;Psyche structure;Quality of life;Recording of previous events;Reporting;Resistance;respiratory;Risk;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 positive;selective attention;Services;Severe Acute Respiratory Syndrome;Short-Term Memory;Sleep;Sleeplessness;social;social relationships;Societies;Surveys;Survivors;sustained attention;Symptoms;System;Testing;Time;Trauma;trend;unvaccinated;Vaccines;Variant;Veterans;Virus;web platform;Work

PROJECT_TITLE: Long-Term Effects of COVID-19 on Cognitive Function and Mental Health


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The Molecular Epidemiology of Cancer Training Program emphasizes a multidisciplinary approach by providing instruction and mentoring to pre- and postdoctoral trainees in both epidemiological methodology and molecular genetic aspects of cancer. Eleven predoctoral trainees have graduated with Ph.D. degrees and eight postdoctoral trainees have finished their training and hold academic or research positions at leading universities and research institutions. In this continuation application, we will continue to focus our training program on molecular epidemiology of cancer with new directions on human microbiota, epigenome, post genome-wide gene-environment interactions, and integration of behavior and molecular epidemiology.

PI_NAMEs: ZHANG, ZUO-FENG  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Molecular Epidemiology of Cancer;Training Programs

PROJECT_TITLE: Molecular Epidemiology Cancer Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses inappropriate antibiotic use in children which occurs commonly and contributes to the development of antimicrobial resistance as well as individual adverse events and unintended consequences. Development of a rich understanding of antibiotic prescribing variability, a novel metric to track this prescribing variability, and a usability informed, mobile antibiotic electronic clinical decision support tool to impact this variability that is effective, efficient, and easily integrated into clinical settings offers the opportunity to substantially reduce inappropriate antibiotic use, ultimately leading to reductions in adverse events and unintended consequences in children. The proposed research is relevant to the Agency for Healthcare Research and Quality’s (AHRQ)’s mission for its focus on utilizing data and technology to improve healthcare quality and safety for children and adolescents, an AHRQ priority population.

PI_NAMEs: MARKHAM, JESSICA LYNN (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Standardizing Antibiotic Prescribing for Children Hospitalized with Infections using Novel Metrics and Electronic Clinical Decision Support Tools

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


PI_NAMEs: ALEKSUNES, LAUREN M (contact)

PROJECT_TERMS: Academy;Achievement;Address;Animal Model;Biological Assay;Biometry;career;chemical threat;Chemical Weapons;Chemistry;Coast Guard;Code;Communication;Communities;course development;curriculum development;design;Development;Distance Education;Distance Learning;distinguished professor;Doctor of Pharmacy;Doctor of Philosophy;drug development;E-learning;Education;education research;Educational Curriculum;Educational workshop;Faculty;Fellowship;field trip;Freedom;Funding;Goals;graduate student;Grant;high school;High School Student;Human Resources;Industry;Infrastructure;Injury;Institution;Interdisciplinary Study;Internships;Journals;Laboratories;laboratory module;Lead;Leadership;Learning;Logic;Machine Learning;medical schools;meetings;member;Mentors;Methods;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;Needs Assessment;New York;Outcome;outreach program;Participant;Pharmacy facility;Pharmacy Schools;Postdoctoral Fellow;Process;professional students;professor;program dissemination;programs;Reagent;recruit;Reproducibility;Research;Research Personnel;Resources;responsible research conduct;Risk Assessment;Rotation;Science;skill acquisition;Students;success;symposium;Talents;Teaching Materials;Technology;Tissues;Toxicology;Training;Training Activity;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Visit;Work;Workforce Development;Writing

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Eye Disease and Disorders of Vision;Lung;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PI_NAMEs: HECK, DIANE E (contact)

PROJECT_TERMS: Advanced Development;Agreement;Animal Model;antagonist;Antibodies;antimicrobial;Cavia;chemical threat;Chemicals;Cholinesterases;Clinical Research;Clinical Trials;Cornea;Corneal Injury;Data;Dermal;Doctor of Pharmacy;Doctor of Philosophy;Doxycycline;drug candidate;Drug Delivery Systems;drug development;Drug Evaluation;Drug Formulations;Drug Kinetics;efficacy study;Emergency Situation;Ensure;Evaluation;Exposure to;Eye Injuries;FDA approved;Funding;Generations;Goals;Government;Grant;healing;Human Resources;improved;in vivo;Inflammatory;Inhalation;Injury;Investigational Drugs;Investigational New Drug Application;Label;Lead;Legal patent;Lung;lung injury;Marketing;Matrix Metalloproteinases;Mechlorethamine;Medical;meetings;member;Methods;Miniature Swine;Modeling;Mustard;Mustard Gas;Non-Steroidal Anti-Inflammatory Agents;novel therapeutics;Oxytetracycline;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Poison;pre-clinical;pre-Investigational New Drug meeting;preclinical development;preclinical efficacy;Prodrugs;product development;programs;Property;PTGS2 gene;Publications;Readiness;Regulatory Affairs;Research;Research Contracts;Research Personnel;Safety;Science;Skin;Skin injury;skin wound;Sterile coverings;Terrorism;Therapeutic;therapeutic development;TNF gene;Toxic effect;Toxicology;Translations;United States National Institutes of Health;Universities;vapor;Vesicants;Work;wound dressing

PROJECT_TITLE: Scientific Core - Pharmacology and Drug Development


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Cross-priming of CD8+ T cells by conventional Type 1 dendritic cells (cDC1) is necessary for effective antitumor therapy, yet there is no established method for measuring T cell cross- or direct-priming in vivo. This project seeks to define a signature of cross-primed T cells using RNA-seq of tumor-specific T cells isolated from H2Kd-/- tumor-bearing mice that can only cross-prime T cells, or allogeneic mice that can only directly prime T cells via direct tumoral antigen presentation. This will produce cross- and direct-primed T cell signatures that can be used to guide design of immunotherapies by targeting novel checkpoints or costimulatory receptors, to monitor responses to immunotherapy, and to predict responses to checkpoint blockade and similar therapies.

PI_NAMEs: LUBITZ, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adoptive Transfer;Allogenic;Animal Model;anti-PD-1;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;Autoantigens;Automobile Driving;cancer infiltrating T cells;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Separation;chemokine;Cross Presentation;Cross-Priming;CXCL9 gene;cytotoxicity;Defect;Dendritic Cells;design;Development;effective therapy;Exhibits;Failure;Flow Cytometry;FLT3 ligand;immune checkpoint blockade;Immune response;Immunologic Monitoring;Immunotherapy;improved;in situ vaccination;in situ vaccine;in vivo;Inbred BALB C Mice;Interferon Type II;Interleukin-12;Interleukin-2;Intrinsic factor;Knock-out;Luciferases;Lymphoma;Malignant Breast Neoplasm;Measures;Mediating;Methods;Modeling;Monitor;mouse model;Mus;Mutation;neoantigens;neoplastic cell;new therapeutic target;novel;Outcome;Outcome Study;patient subsets;Patients;PD-1 blockade;Phenotype;pre-clinical;predicting response;programs;Radiation therapy;receptor;recruit;Resistance;response;Role;Sorting;success;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;therapy design;Tissues;tool;transcriptome sequencing;transcriptomics;Transfection;tumor;Tumor Antigens;tumor growth;Vaccination

PROJECT_TITLE: Defining a cross-primed anti-tumor T cell signature to guide immunotherapy development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PI_NAMEs: SINKO, PATRICK J. (contact)

PROJECT_TERMS: Amino Acids;Analytical Chemistry;Animals;Anti-Inflammatory Agents;aqueous;Biological Products;Carbonates;Clinic;Clinical;Clinical Trials;Contracts;delivery vehicle;density;Dermal;design;Development;Doctor of Philosophy;Dose;drug candidate;Drug Delivery Systems;drug development;Drug Kinetics;Drug Targeting;Esters;Excipients;Eye;FDA approved;Formulation;Gel;Goals;Grant;healing;Human Resources;Hybrids;Hydrogels;In Situ;In Vitro;in vivo;innovation;Lead;lead candidate;lead optimization;Legal patent;Libraries;Link;Lipids;lipophilicity;Lung;manufacture;manufacturing organization;Mechlorethamine;MicroRNAs;mouse model;Mustard Gas;nano;nanoparticle;nanopolymer;novel drug class;novel therapeutics;Pathway interactions;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Pharmacology;Pharmacy (field);Poisoning;Polyamines;Polymers;pre-clinical;pre-Investigational New Drug meeting;prevent;Procedures;Process;process improvement;Prodrugs;Product Approvals;product development;prospective;Proteins;Regimen;research and development;Research Personnel;Research Project Grants;Route;scale up;Sebum;Skin;Skin injury;Solubility;Specific qualifier value;Suspensions;technology platform;Testing;Therapeutic;Toxic effect;Toxicokinetics;Toxicology;Translating;Universities;Vanilloid;Vesicants;Work;wound

PROJECT_TITLE: Scientific Core - Pharmaceutics and Medicinal Chemistry