ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE In this proposal, we will apply adductomics to investigate environmental risk factors for breast cancer in the Sister Study cohort. Adduct profiles will be quantified in plasma from 1,800 incident breast cancer cases and a random sample of 1,800 Sister Study participants. We will also perform secondary analyses to investigate associations between adducts and environmental exposures.

PI_NAMEs: FUNK, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;adduct;Air Pollution;Alcohol consumption;Biological;Biological Markers;biomarker discovery;Blood;Body Size;Breast;breast cancer diagnosis;Breast Cancer Risk Factor;Cancer Biology;cancer biomarkers;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer subtypes;Chemicals;coarse particles;cohort;Cohort Studies;Complex;Computer software;Custom;Data;design;Diagnosis;Dose;Environment;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;ERBB2 gene;experimental study;Exposure to;fine particles;forging;Goals;Home;Human;Incidence;insight;Institute of Medicine (U.S.);interest;Intervention;Link;Lipid Peroxidation;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Menopausal Status;Methodology;Modeling;modifiable risk;Nature;Nitrogen Dioxide;novel marker;novel strategies;Oxidation-Reduction;Oxidative Stress;Participant;Pathway interactions;Plasma;prospective;Prospective cohort;Proteins;Public Health;Random Allocation;Reproductive History;Research;residence;Resolution;response;Response Latencies;Risk Factors;Role;Sampling;Science;secondary analysis;Serum Albumin;Sister;Smoking;Source;Time;time use;tool;tumor progression;Woman;women's diagnosis

PROJECT_TITLE: Investigating Environmental Risk Factors for Breast Cancer Using Adductomics

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Diabetes;Dietary Supplements;Genetics;Human Genome;Nutrition;Obesity;Prevention

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The project focuses w-3 fatty acids activating FFAR4 and other GPCRs to trigger adipogenesis and insulin secretion in pancreatic b cells. Our functional studies, proteomics, and CRISPR screens comprise a multiomics approach to new human disease genes and targets for diabetes.

PI_NAMEs: JACKSON, PETER KENT (contact);KIM, SEUNG K

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Acceleration;Adenylate Cyclase;adipocyte differentiation;Adipocytes;Adipose tissue;adult stem cell;Aging;Agonist;Antibodies;B-Lymphocytes;Beta Cell;Biological Assay;Blood Vessels;BODIPY;Bromodeoxyuridine;Calcium;cell type;Cells;Cilia;CRISPR screen;Cyclic AMP;Diabetes Mellitus;diabetic;diabetic patient;dietary;differentiation protocol;Dinoprostone;Disease Progression;Dyes;Early identification;Event;Fatty acid glycerol esters;Fatty Acids;feeding;FFAR1 gene;Formulation;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gender;Genes;Genetic;genetic testing;genome wide screen;genome-wide;Glucagon;glucagon-like peptide 1;Glucose;Glucose Intolerance;Growth;Growth Factor;High Fat Diet;Histologic;Hormones;Human;human disease;Human Genetics;Hypertrophy;Hypoxia;IGF1 gene;immune activation;improved;In Vitro;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin secretion;insulin signaling;insulinoma;islet;Islets of Langerhans;Knock-out;Knockout Mice;Ligands;Link;lipid biosynthesis;Lipid Inclusion;Lipids;Mesenchymal;Metabolic;Metabolism;Modeling;mouse model;multiple omics;Mus;Nutritional;obese patients;Obesity;Omega-3 Fatty Acids;Organism;Pathway interactions;Patients;Pharmacology;phosphoric diester hydrolase;Platelet-Derived Growth Factor alpha Receptor;Production;programs;Prostaglandin E Receptor;Prostaglandins;Proteomics;Publishing;receptor;Regulation;Reporter;S phase;Saturated Fatty Acids;sensor;Sex Differences;Signal Pathway;Signal Transduction;stem cell population;stem cells;Structure of beta Cell of islet;synergism;System;Tamoxifen;Testing;therapeutically effective;Tissue Expansion;Tissues;trafficking;Translation Initiation;Translations

PROJECT_TITLE: Fatty Acid Signaling via GPCRs in Primary Cilia Controls Adipogenesis and Insulin Secretion, Regulating Obesity and Diabetes


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE While an important focus of Transfusion Medicine has been to maintain immune compatibility of blood components as well as the safe and appropriate use of blood products, the expansive growth in knowledge of blood cell biology has correspondingly increased options for investigation. Transfusion Medicine scientists and specialists now direct the generation of novel blood component products and the translation of cell-based therapies. Our postdoctoral training program is tailored to meet the recognized need for scientific training of individuals to further advance knowledge and clinical use of hematopoietic cellular therapies to treat diseases.

PI_NAMEs: MANIS, JOHN P (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Biology;Cell Therapy;Transfusion

PROJECT_TITLE: Transfusion Biology and Cellular Therapies

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Human Genome;Neurosciences;Prevention;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Stroke remains a leading cause of cardiovascular-related mortality and morbidity in the United States and worldwide, with stroke prevention and outcome efforts hampered by a lack of understanding of the basic mechanisms. Large genome-wide association studies (GWAS) of ischemic stroke (IS) populations have been successful at identifying stroke-risk-associated loci with small effect sizes, however, the role of copy number variation (CNV) variation in stroke susceptibility has yet to be explored. We hypothesize that CNV analyses of existing GWAS and exome array data in our assembled data sets of over 24,500 cases and 43,500 controls will be a highly effective and cost-efficient methodology to identify novel associations illuminating stroke mechanisms, treatment targets, and outcome drivers.

PI_NAMEs: COLE, JOHN W. (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Address;Adult;Affect;African;Age;Bioinformatics;Biological;Biological Markers;Blood;Blood Pressure;Cardiovascular system;case control;Caucasians;causal variant;Cause of Death;circulating biomarkers;Coagulation Process;Complex;Copy Number Polymorphism;cost;cost efficient;Data;Data Set;Detection;disability;Disease;Drug Targeting;ethnic diversity;Ethnic Origin;Etiology;European;exome;experience;Functional disorder;Genes;Genetic;Genetic study;genome wide association study;genome-wide;Genotype;Heritability;improved;Inflammation;insight;Interdisciplinary Study;International;Ischemic Stroke;Leadership;London;Manuals;Measures;men;Messenger RNA;metabolomics;Methodology;Methylation;MicroRNAs;Morbidity - disease rate;mortality;novel;Outcome;Pathway interactions;Phenotype;Population;Positioning Attribute;Predisposition;Prevention;programs;Proteomics;Research;Research Personnel;Resources;Risk;Risk Factors;RNA;Role;sex;Stroke;stroke outcome;Stroke prevention;stroke risk;Susceptibility Gene;Sweden;tool;Training;Trans-Omics for Precision Medicine;treatment and outcome;United States;Variant;Woman

PROJECT_TITLE: CNV And Stroke (CaNVAS)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Kidney Disease;Neurodegenerative;Neurosciences;Organ Transplantation;Prevention;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Older kidney transplant (KT) patients are at a higher risk of developing Alzheimer’s Disease and Related Dementia (ADRD) than their healthy community-dwelling older adult counterparts. This proposal aims to: 1) integrate ADRD research into existing aging and renal studies (prospective cohort study and RCT); 2) develop a scientific protocol to study cognitive prehabilitation in KT patients; and 3) to develop a national renal aging network. By developing a sustainable research infrastructure to explore ADRD in a novel population of older KT patients we will impact the lives of the 100,000 patients who experience physical and cognitive decline while waiting for KT.

PI_NAMEs: MCADAMS DEMARCO, MARA A. (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: 12 year old;Address;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Award;career;career development;Chronic Disease;Classification;Clinical Research;Cognitive;Cognitive aging;cognitive function;Collaborations;Communities;Consensus;Data;Dedications;Dementia;dementia risk;Dependence;Diagnosis;Diagnostic;diagnostic criteria;disability;Disease Management;Elderly;End stage renal failure;Epidemiology;experience;Faculty;Fostering;Foundations;frailty;Funding;Geriatrics;Goals;Habilitation;Hemodialysis;high risk;Impaired cognition;Interdisciplinary Study;interest;International;Intervention;Kidney;Kidney Transplantation;Knowledge;Knowledge acquisition;Learning;meetings;Mentors;mortality risk;Nephrology;Neurocognitive;Neuropsychology;next generation;novel;older adult;Older Population;Outcome;Patient risk;Patients;Peer Review;Persons;Pharmaceutical Preparations;Phenotype;preservation;prevent;programs;Prospective, cohort study;Protocols documentation;Provider;Publications;Publishing;Research;Research Design;Research Infrastructure;Research Personnel;Risk;Scientist;Self Care;skills;Subgroup;symposium;Testing;Time;Training;Transplant Recipients;Transplant Surgeon;Transplantation;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Cognitive prehabilitation to prevent Alzheimer's disease after kidney transplantation

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: This research grant is designed to examine the importance of repurposing two drugs that hold promise for improving glucose metabolism. Mirabegron and tadalafil augment levels of cAMP and cGMP, respectively, and we will determine whether mirabegron, tadalafil or a combination of these drugs improve glucose homeostasis. These drugs both cause induction of beige adipose, and this study will also explore mechanisms for their effects.

PI_NAMEs: KERN, PHILIP A (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adrenergic Agonists;Adrenergic beta-Agonists;Agonist;American;Attenuated;Beta Cell;beta-adrenergic receptor;Bladder;Blood capillaries;blood glucose regulation;Body Weight decreased;Brown Fat;Cell Physiology;clinical efficacy;Clinical Trials;clinically relevant;Combined Modality Therapy;comorbidity;Consumption;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Cyclic Nucleotides;Data;density;design;Diabetes Mellitus;diabetes prevention program;Disease;Drug Combinations;Drug Targeting;Effectiveness;effectiveness evaluation;Exercise;Fatty acid glycerol esters;FDA approved;Fiber;Glucose;glucose metabolism;glucose tolerance;Glycosylated hemoglobin A;Goals;heart disease risk;Heart Diseases;Human;improved;Individual;Inflammation;inhibitor;inhibitor therapy;Insulin Resistance;insulin secretion;insulin sensitivity;Life Style;Ligands;Link;Lipids;Lipolysis;Mediating;Metabolic;Methods;Mission;Multicenter Trials;Muscle;Muscle Fibers;National Institute of Diabetes and Digestive and Kidney Diseases;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oral;oral glucose tolerance;Overactive Bladder;p38 Mitogen Activated Protein Kinase;Participant;Pathway interactions;Pharmaceutical Preparations;phosphodiesterase V;placebo controlled trial;Prediabetes syndrome;prevent;protein activation;Recommendation;Research;Research Project Grants;response;Risk Factors;Rodent;side effect;sildenafil;Skeletal Muscle;Smooth Muscle;subcutaneous;tadalafil;Thinness;Treatment Effectiveness;uncoupling protein 1;Woman

PROJECT_TITLE: Mirabegron and tadalafil effectiveness for treatment of prediabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Metabolites serve as powerful inter-organelle signaling molecules that modify the epigenome and have attracted great attention as both the mediators of tumorogenesis and novel therapeutic targets in cancer. We will investigate the impact of a hypercholesterolemia-induced metabolite, 2-hydroxyglutarate, in macrophages and its role in inflammation and atherogenesis. Our work will specifically provide insight into the pathways leading to hypercholesterolemia-induced production of 2-hydroxyglutarate and its epigenetic inflammatory targets in macrophages while investigating novel therapeutic opportunities in atherosclerosis through targeting this immunemetabolite.

PI_NAMEs: SHAH, PREDIMAN KRISHAN (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: activating transcription factor 1;activating transcription factor 4;alpha ketoglutarate;antagonist;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Attention;biological adaptation to stress;Cardiovascular Diseases;Cessation of life;Cholesterol;Chronic;Chronic Disease;cofactor;Coronary heart disease;Data;Development;Dioxygenases;DNA Modification Process;early onset;EIF-2alpha;Endoplasmic Reticulum;endoplasmic reticulum stress;Epigenetic Process;epigenome;Etiology;Eukaryotic Initiation Factors;Family;Genes;genetic approach;Genetic Models;Human;hypercholesterolemia;Hyperlipidemia;Hypoxia;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Knock-in;Knowledge;Link;Lipids;Literature;Macrophage;Malignant Neoplasms;Mediating;Mediator;Membrane;Metabolic;Metabolic Pathway;Methylation;Mitochondria;Mus;Myelogenous;Myeloid Cells;Myocardial dysfunction;Myocardial Infarction;new therapeutic target;novel therapeutics;Onset of illness;Organelles;oxidation;Oxidoreductase;Pathway interactions;Phosphoglycerate dehydrogenase;Phosphorylation;Phosphotransferases;prevent;Production;Protein Dephosphorylation;Recovery;response;Role;Saturated Fatty Acids;Signal Transduction;Signaling Molecule;small molecule;Somatic Mutation;Sterility;Stimulus;Stress;Stress Response Signaling;Supplementation;Therapeutic;therapeutic target;Toxic effect;transcriptome;Translations;Treatment Efficacy;vascular inflammation;Work

PROJECT_TITLE: A hypercholesterolemia-induced immunometabolite in atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Leukemia (ALL) remains one of the leading causes of cancer death in persons <20 years old and clinical challenges relate to incomplete understanding of the developmental origin of ALL and a lack of understanding aberrant signals that drive T-ALL characteristics. The goal of this project is to characterize the diversity in the bone marrow of pediatric T cell leukemia patients, mechanistically understand leukemic Ras-PI3K signals and cell metabolism with single cell resolution, and leverage obtained insights to test new combination therapies. The proposed research will provide mechanistic insights on aberrant Ras signals in T cell leukemia and cancer as a whole with high-dimensional approaches and will be of relevance to the mission of the NIH and of interest to a broad audience of cancer researchers and clinicians.

PI_NAMEs: ROOSE, JEROEN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 20 year old;Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Bar Codes;biobank;Biochemical;Biological;Bone Diseases;Bone Marrow;Bone Marrow Diseases;Bone Marrow Stem Cell;Cancer Etiology;cancer type;CCL21 gene;Cell Line;Cells;Cellular Metabolic Process;Cessation of life;Characteristics;chemotherapy;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Precursor T Lymphoblastic Leukemia;Clinic;Clinical;Combined Modality Therapy;CRISPR interference;cytokine;Data;Dependence;design;Development;DNA Sequence Alteration;Epithelial Cells;experience;fitness;Flow Cytometry;FRAP1 gene;Genetic;genome-wide;Goals;Grant;Guanosine Triphosphate;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;high dimensionality;Immune;In Vitro;in vivo;in vivo evaluation;inhibitor;inhibitor therapy;innovation;insight;interest;kinase inhibitor;KRASG12D;Lead;leukemia;Leukemic Cell;Malignant Neoplasms;Measurement;Measures;Metabolic;Metabolism;Methods;Mission;Modeling;Molecular;mouse model;Mus;Mutation;new combination therapies;novel;Nutrient;Oncogenic;overexpression;Pathway interactions;Patients;Persons;Phenotype;Phosphatidylinositide 3-Kinase Inhibitor;Phosphatidylinositols;Phosphotransferases;Point Mutation;pre-clinical;precision medicine;preclinical trial;programs;Progress Reports;Proto-Oncogene Proteins c-akt;ral Guanine Nucleotide Exchange Factor;RALGDS gene;Research;Research Personnel;Resistance;Resolution;Role;Sampling;Signal Transduction;small molecule inhibitor;stem;stem cells;synergism;T-Cell Leukemia;technology platform;Testing;Time;Tubulin;United States National Institutes of Health;Vincristine

PROJECT_TITLE: Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cerebrovascular;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative We have discovered that the prion protein Prnd plays key roles in promoting the formation of new blood vessels. In this project, we will characterize signaling pathways activated by Prnd in vascular endothelial cells during development and disease.

PI_NAMEs: MCCARTY, JOSEPH H (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Adult;age related neurodegeneration;angiogenesis;Biochemical;blood vessel development;Blood Vessels;Body System;Brain;Brain Diseases;Cell Culture System;Cell Differentiation process;cell growth;Cell surface;Cell Surface Proteins;Cells;cellular imaging;Central Nervous System;Central Nervous System Diseases;central nervous system vasculature;Cerebrovascular system;Chimeric Proteins;Communication;Cues;Cytoplasm;Cytoplasmic Tail;Data;Databases;Defect;Development;Disease;Endocytosis;Endothelial Cells;Endothelium;Environment;Event;experimental study;Family member;Fluorescence Microscopy;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Family;Genes;Genetic;genetic manipulation;Genetic Screening;Genetically Engineered Mouse;Growth;Growth Factor;Growth Factor Receptors;Human body;imaging modality;in vivo;Integral Membrane Protein;Internet;Knowledge;Leukoencephalopathy;Link;Mediating;member;migration;Morphogenesis;Mus;nervous system development;Neurodevelopmental Disorder;Neuroglia;Neurons;new therapeutic target;Normal tissue morphology;Norrie's disease;novel;open source;Organ;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathology;Pathway interactions;Pericytes;Perinatal subependymal hemorrhage;Permeability;pharmacologic;Physiology;Play;Prions;protein protein interaction;PrP;Receptor Protein-Tyrosine Kinases;Recombinants;Resolution;Retina;retina blood vessel structure;Retinopathy of Prematurity;Role;Signal Pathway;Signal Transduction;Specific qualifier value;Spinal Cord;Structure;System;Testing;tool;Vascular Endothelial Cell;Vascular Endothelium;Vascular Permeabilities;Vascular System;Vascularization;white matter

PROJECT_TITLE: Analyzing the Endothelial Cell-Expressed Prion Gene Prnd in Vascular Development

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  Acute Respiratory Distress Syndrome (ARDS) is a common pulmonary disease with high morbidity and mortality, and specific therapies to treat ARDS are lacking. Regulatory T Cells (Tregs) promote lung resolution after acute injury; however, the mechanisms involved in Treg-directed repair are not well characterized. We propose to identify the mechanisms through which Tregs promote reparative processes, which may uncover new targets to help accelerate lung repair and recovery for ARDS patients.

PI_NAMEs: MOCK, JASON ROBERT (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;adaptive immunity;alveolar epithelium;Autoantigens;Autoimmunity;Cell Cycle Kinetics;Cell Physiology;Cell Proliferation;Cell Separation;Cells;Coculture Techniques;Code;Complement;cytokine;demethylation;Disease;Epithelial Cells;Epithelium;Experimental Models;Fibrin;FOXP3 gene;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Histone Deacetylase;Histones;Homing;Immune;immune cell infiltrate;Immune response;Immunity;improved;improved outcome;In Vitro;in vitro testing;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;Injury;Knowledge;Light;Liquid substance;Lung;Lung Diseases;lung injury;lung repair;Lysine;Mediating;MME gene;Morbidity - disease rate;mortality;Mus;novel;pathogen;Patients;Peripheral;Phase;Play;Pneumonia;Process;Proliferating;Protein-Serine-Threonine Kinases;Proteolysis;Publishing;Recovery;Regulatory T-Lymphocyte;repaired;reparative process;Resolution;response;response to injury;restraint;Role;Sentinel;Serine;Severities;Signal Transduction;Streptococcus pneumoniae;Structure of parenchyma of lung;T cell response;T cell therapy;T-Lymphocyte;Technology;Testing;therapeutic development;therapy outcome;Thymus Gland;Tissues;Transcript;transcriptome;transcriptomic profiling;Type II Epithelial Receptor Cell;Untranslated RNA

PROJECT_TITLE: Defining the Role of Regulatory T Cells in Resolution of Acute Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Preterm infants often have challenges to feed orally, leading to growth and developmental delay, prolonged hospitalization, and increased health care cost. The ability to feed orally is dependent on neurobehaviors, which can be impaired through epigenetic modifications that occur in response to early life stress exposure. Understanding the role of stress-related epigenetic modifications in oral feeding skill development can guide future development of strategies to promote successful oral feeding and nutrition, reduce post-discharge feeding difficulties, lower risk for life-long maladaptive eating behaviors, and decrease health care cost.

PI_NAMEs: GRIFFITH, THAO T (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Achievement;Address;Admission activity;Affect;Age;Assessment tool;Behavioral;biobehavior;Biological;biological adaptation to stress;Biological Markers;Brain;Breathing;Cells;Clinical;Data;Deglutition;Desire for food;Development;Developmental Delay Disorders;Discharge Plannings;DNA;DNA Methylation;early life stress;Eating;Eating Behavior;Enrollment;Epigenetic Process;experience;Exposure to;Failure to Thrive;feeding;Feeding behaviors;Future;Genes;Gestational Age;Glucocorticoids;Goals;Growth;Health;Health Care Costs;high risk;hospital readmission;Hospitalization;Hydrocortisone;Hypothalamic structure;Impairment;imprint;Infant;Infant Health;Knowledge;longitudinal, prospective study;Modeling;Modification;Movement;Neonatal;neonatal care;Neonatal Intensive Care Units;neonatal period;neurobehavior;neurobehavioral;Neuronal Plasticity;novel;NR3C1 gene;nutrition;Oral;oral motor;Outcome;personalized management;Physiological;Pituitary Gland;Premature Infant;Process;promoter;recruit;Regulation;Research;response;Risk;Role;Saliva;Sampling;skill acquisition;skills;Stress;stressor;sucking;System;Variant

PROJECT_TITLE: Epigenetics Embedding of Oral Feeding Skill Development in Preterm Infants

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(81)]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative  Iron-deficiency anemia of chronic kidney disease (CKD) is associated with increased morbidity and mortality and occurrs in conjunction with dramatic morphological alterations in bone. Additional studies demonstrate coupling of iron deficiency with reducing polyamine synthesis, which is important for osteoblast differentiation. Thus, iron-deficiency anemia may be linked to the development of CKD-mineral bone disorder (CKD-MBD) through altering polyamine concentrations which will be examined in this proposal to elucidate novel therapeutic targets.

PI_NAMEs: CLINKENBEARD, ERICA L (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acetyltransferase;Address;Adenine;Affect;American;Automobile Driving;Award;Biopsy;bone;Bone Diseases;Bone Formation Inhibition;bone fragility;bone loss;Bone Marrow;Bone Resorption;bone turnover;Calcium;Calvaria;Catabolism;Cell Differentiation process;cell growth;Cells;Chronic;Chronic Kidney Failure;comorbidity;comparison control;Coupling;Death Rate;Development;Diet;Disease;DNA;Enzymes;Epigenetic Process;Exhibits;Foundations;Fracture;fracture risk;Functional disorder;Gene Expression;General Population;Genetic;Hip Fractures;Histologic;Homeostasis;Impairment;improved;In Vitro;in vivo;innovation;inorganic phosphate;Intervention;Iron;iron deficiency;Iron deficiency anemia;Kidney Failure;Knowledge;Link;loss of function mutation;Mediating;Metabolism;mineralization;Minerals;Mission;Modeling;Morbidity - disease rate;Morphology;mortality;Mus;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Outcome;overexpression;Pathogenicity;Pathology;Patients;pharmacologic;Phosphorus;Polyamine Catabolism;polyamine oxidase;Polyamines;Porosity;preservation;Production;protective effect;Proteins;Putrescine;Regimen;Renal function;Reporting;Research;Research Personnel;Research Project Grants;Rodent;Role;Serum;small molecule;Snyder-Robinson syndrome;Spermidine;Spermine;Spermine Synthase;stem cells;Supplementation;Testing;Therapeutic;Transferase;Transgenic Organisms;translational applications;Up-Regulation;Vascular calcification;Work

PROJECT_TITLE: Role of disrupted polyamine synthesis during CKD-MBD related bone loss

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Dietary lipids must be properly stored within adipocyte lipid droplets (LDs) to maintain health, and defects in lipid storage are associated with metabolic syndromes including obesity, cardiovascular disease, and type 2 diabetes. This project capitalizes on our recent work in Drosophila where we discovered a highly conserved protein called Snz that connects LDs to the plasma membrane of adipocytes, thus regulating lipid exchange with extracellular lipid pools at the cell periphery. Accomplishing the aims will provide new mechanistic insights into how adipocytes and other fat-storing cells coordinate lipid storage with mobilization during metabolic cues, as well as how cells properly organize fat stores to maintain homeostasis.

PI_NAMEs: HENNE, MIKE  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: absorption;Actins;Adipocytes;Biogenesis;Biological Models;Blood;Cardiovascular Diseases;Cell membrane;Cell secretion;Cell surface;Cells;Cerebellar Ataxia;Collaborations;Coupled;Coupling;Cues;Cytoplasm;Data;Defect;diacylglycerol O-acyltransferase;Dietary Fats;Diffusion;Disease;Drosophila genus;Endoplasmic Reticulum;Environment;Enzymes;extracellular;Fatty Acid Desaturases;Fatty acid glycerol esters;Fatty Acids;Genetic Screening;Health;Hepatocyte;Homeostasis;Homologous Gene;Human;insight;Knockout Mice;Lead;Link;lipid metabolism;lipidomics;Lipids;Lipolysis;long chain fatty acid;Mammalian Cell;Metabolic;Metabolic Diseases;Metabolic syndrome;milk secretion;Molecular;Motivation;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organelles;Orthologous Gene;Paper;Peripheral;Positioning Attribute;Process;Production;Protein Family;Proteins;Publishing;Reporting;response;Role;segregation;Site;Tissues;Triglycerides;uptake;Work

PROJECT_TITLE: Mechanisms of lipid droplet organization and functional diversification

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: The research proposed in this application will yield key insights into fundamental molecular mechanisms that underlie synaptic transmission and some forms of information processing in the brain. This knowledge is critical to understand how the brain and the nervous system in general function. Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders.

PI_NAMEs: RIZOREY, JOSE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Alzheimer's Disease;Biological Assay;biophysical techniques;Blood Pressure;Brain;Cellular biology;Communication;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Defect;Development;Disease;Docking;Electrophysiology (science);experimental study;Goals;Heart Rate;information processing;insight;Insulin;interdisciplinary approach;Intracellular Membranes;Knowledge;Membrane;Membrane Fusion;Molecular;Nervous System;Nervous System Disorder;Neurons;neurotransmitter release;NMR Spectroscopy;novel;novel strategies;Parkinson Disease;Pharmaceutical Preparations;Physiological;presynaptic;Process;protein complex;Proteins;reconstitution;Regulation;Research;Schizophrenia;SNAP receptor;success;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptotagmin;Testing;therapy development;three dimensional structure;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of neurotransmitter release and its regulation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Diabetes

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Attaching polyethylene glycol (PEG) to peptide and protein drugs addresses their major limitation of rapid clearance from the body. Unfortunately, this technology, which has been a mainstay of the pharmaceutical industry for the past three decades, is now showing its age because many patients have preexisting PEG antibodies that interfere with the drug or cause life-threatening side-effects. This research will solve this problem by developing a new version of PEG that does not have this problem, with the added bonus of a slow-release formulation that, upon injection under the skin, further enhances drug efficacy.

PI_NAMEs: CHILKOTI, ASHUTOSH  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Age;Allergic Reaction;American;Antibodies;Behavior;Binding;Biological Availability;Biological Products;Blood Circulation;Blood Glucose;blood glucose regulation;Breathing;Clinical;copolymer;Data;design;Diabetes Mellitus;diabetic;Diabetic mouse;Dose;drug candidate;Drug Delivery Systems;drug efficacy;Drug Industry;Drug Kinetics;drug market;drug withdrawal;ethylene glycol;FDA approved;Formulation;GLP-I receptor;Glucagon;Glycosylated Hemoglobin;Goals;Half-Life;Hemoglobin concentration result;Hour;immunogenicity;improved;in vitro activity;in vivo;Individual;Injectable;Injections;insulin secretion;islet;Islet Cell;Islets of Langerhans;Kidney;Kinetics;Length;Life;Marketing;Medicine;Methacrylates;Methodology;Methyl Ethers;Molecular Weight;Mus;new technology;next generation;Non-Insulin-Dependent Diabetes Mellitus;Oligonucleotides;Patients;peptide drug;Peptides;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phase III Clinical Trials;Phase Transition;Plasma;Polyethylene Glycols;Polymers;Property;Proteins;Research;Reticuloendothelial System;Sampling;side effect;Site;Skin;Specificity;Structure;subcutaneous;Subcutaneous Injections;System;Technology;Temperature;Testing;Therapeutic;Transition Temperature;United States National Institutes of Health;Vertebral column

PROJECT_TITLE: Injectable PEG-like Conjugate for Sustained Delivery of a Peptide Drug for Type 2 Diabetes Treatment

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Antibodies, especially those of the IgG type, are central to immunity and comprise a wide class of biologic therapies. In addition to binding an antigen target, IgG antibodies direct the response of immune cells through Fc-gamma receptor binding. This project aims to better understand how antibodies influence the behavior of one another in target cell killing when present together.

PI_NAMEs: MEYER, AARON SAMUEL (contact);NIMMERJAHN, FALK

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Affinity;Antibodies;antibody-dependent cell cytotoxicity;antigen binding;Antigen Targeting;Antigen-Antibody Complex;Antigens;B-Lymphocytes;Behavior;behavior influence;Binding;Biological Response Modifier Therapy;Biological Response Modifiers;Blood Platelets;cell killing;cell type;Cells;Complex;Computer Models;design;Disease;Effector Cell;Engineering;Equilibrium;Excision;Fc domain;glycosylation;Goals;Human;IgG Receptors;Immune;Immune response;Immune system;Immunity;Immunoglobulin Constant Region;Immunoglobulin G;improved;In Vitro;in vivo;insight;Investigation;Link;Logic;Macrophage;manufacture;Maps;Measures;Mediating;Modeling;Monoclonal Antibodies;monocyte;Mus;Phagocytosis;Population;Process;Property;Publishing;receptor binding;Regulation;response;Role;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;tumor;Work

PROJECT_TITLE: Mapping the effector response space of antibody combinations


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Congenital Structural Anomalies;Disability Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: The outcomes of this study will provide a method to accurately measure body fat in the clinical environment and information on energy expenditure in youth with spina bifida. This population is at a higher risk of obesity then the general population. These findings will provide a method to screen and support prevention and treatment of obesity through the ability to accurately identify the youth’s weight status and to recommend daily caloric needs for this high-risk population.

PI_NAMEs: POLFUSS, MICHELE  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accelerometer;Address;Adult;Age;Age of Onset;age stratification;Algorithms;arm;Behavior;Biolectric Impedance;Body Composition;Body fat;Body Height;Body mass index;Body measure procedure;Body Weight Changes;Calories;Categories;Characteristics;Child;Childhood;Clinic;Clinical;clinical practice;clinical research site;Clinical Sciences;Clinical Trials;comorbidity;cost effective;Cross-Sectional Studies;Data;Dietary intake;Dietary Practices;disability;doubly-labeled water;Economic Burden;Energy Intake;Energy Metabolism;Ensure;Environment;Equation;Equilibrium;Fatty acid glycerol esters;feasibility testing;Frequencies;Funding;Future;General Population;Geographic Locations;Goals;Health;health management;Health Promotion;healthy weight;Height;high risk;high risk population;Individual;Intervention;Knee;Knowledge;Length;Literature;Measurement;Measures;Medical;Methods;Mission;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;nutrition;Obesity;obesity prevention;obesity risk;obesity treatment;Outcome Study;Participant;peer;personalized medicine;Physical activity;Pilot Projects;Population;population health;Prevalence;prevent;Prevention;Productivity;programs;psychologic;Puberty;Recommendation;Reporting;Research;Research Institute;Research Priority;Risk;Sampling;Science;Self Management;Self-Help Devices;sex;Site;Spinal Dysraphism;Testing;total energy expenditure;Translational Research;waist circumference;Walking;Weight;Weight maintenance regimen;Wheelchairs;Youth

PROJECT_TITLE: Body Composition and Energy Expenditure in Youth with Spina Bifida

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco

ORG_CITY: HONOLULU

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE This proposal seeks to examine ethnic differences in substance use behavior before and after the spread of COVID-19 across Asians and NHOPI, with reference to Whites. In addition, we will test a new model that attempts to explain the mechanisms of the potential increase in substance use post-COVID among emerging adults (18-29 year olds). Findings are likely to help policy-makers and health promotion scientists to address the adverse effects of the COVID-19 pandemic on the mental health and substance use behavior of vulnerable populations.

PI_NAMEs: POKHREL, PALLAV  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adverse effects;Affect;Alcohols;Anxiety;Asian;Asian Pacific Islander;Asian population;Behavior;biological sex;Businesses;Cardiovascular Diseases;Chinese;cohort;COVID-19;COVID-19 impact;COVID-19 pandemic effects;COVID-19 stress;Data;Data Collection;Decision Making;demographics;Disparity population;emerging adult;emerging adulthood;ethnic difference;Event;Exposure to;Face;Filipino;Financial Hardship;Funding;Hawaii;Hawaiian;Health;health disparity;Health Promotion;high risk;illicit drug use;Illicit Drugs;Indigenous;innovation;Institution;interest;Japanese;Knowledge;Life;Loneliness;Malignant Neoplasms;marginalization;Marijuana;Mediating;Mental Depression;Mental Health;Modeling;Modern 1601-history;Morbidity - disease rate;mortality risk;Native Hawaiian or Other Pacific Islander;Pacific Islander;Pacific Islands;pandemic disease;perceived discrimination;Policy Maker;Population;post-COVID-19;Prevalence;psychosocial;recruit;Research;Research Design;response;Risk;Sampling;Scientist;Self Medication;social culture;social disparities;Social isolation;Stress;Stress and Coping;Subgroup;substance use;substance use prevention;Surveys;symptomatology;Testing;theories;Tobacco;tobacco control;tobacco products;Vulnerable Populations;Woman

PROJECT_TITLE: Ethnic Differences in the Effects of COVID on the Substance Use Behavior of Emerging Adults


NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The occurrence of heart failure in cancer survivors is devastating and continues to rise and is mostly due to the very therapies that were utilized to cure/mitigate cancer. The involvement of sterile inflammation (cardiac inflammasome) and post-translational modifications of some structural cardiac proteins in the development and progression of chemotherapy-induced cardiomyopathy in relation to mitochondrial dysfunction/oxidative stress or other signaling pathways remain rather understudied. In this proposed program, we seek to further explore the role of the cardiac inflammasome as it relates stress signals and potential maladaptive post-translational protein modifications in chemotherapy-induced cardiomyopathy by focusing on the cardiac cell-type involvement as well as novel potential therapeutic strategies to prevent and/or mitigate adverse cardiac remodeling and failure.

PI_NAMEs: SALLOUM, FADI N (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acute myocardial infarction;Attenuated;Blood;Cancer Survivor;cancer therapy;Cardiac;Cardiomyopathies;Cardiotoxicity;Cell Death;cell type;Cellular Stress;chemotherapy;cofilin;cofilin 2;Data;design;Development;Doxorubicin;Exposure to;Failure;Fibrosis;Foundations;Goals;Heart;Heart failure;heart function;Hydrogen Sulfide;Inflammasome;Inflammation;Inflammatory;Injury;interstitial;Investigation;Ischemia;ischemic injury;Knowledge;Literature;Malignant Neoplasms;Mediating;mitochondrial dysfunction;Modality;Mus;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocarditis;Nitric Oxide;novel;Oncology;Oral;oxidation;Oxidative Stress;Patients;Phase I Clinical Trials;Post-Translational Protein Processing;Pre-Clinical Model;preservation;prevent;Preventive;Process;Production;programs;Proteins;Role;Secondary to;Signal Pathway;Signal Transduction;Sterility;Stress;Structural Protein;Therapeutic;Toxic effect;Work

PROJECT_TITLE: Managing Cardiac Toxicities of Cancer Therapy


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE If successful, this proposal will significantly advance our knowledge of how glycolytic metabolism controls bone mass accrual and homeostasis. The successful accomplishment of the experimental plan described in this proposal may identify the transcription factor TFAM as a novel regulator of osteoblastogenesis, and this could lead to the discovery of novel therapeutic strategies to increase bone mass.

PI_NAMEs: SCHIPANI, ERNESTINA  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Affect;Aging;aging related disease;Bioenergetics;Biological;Biology;bone;Bone Marrow;bone mass;Calvaria;Cell Differentiation process;cell type;Cells;Consumption;Cre driver;Data;Development;differentiation in vitro;Electron Transport;Energy Metabolism;Ensure;experimental study;factor A;gain of function mutation;Genes;Genetic Transcription;Glycolysis;Homeostasis;Hypoxia Inducible Factor;Impairment;In Vitro;in vitro Assay;in vivo;Knowledge;Learning;loss of function mutation;Maintenance;Measures;Membrane Potentials;Mesenchymal;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metabolic;Metabolic Bone Diseases;Metabolism;Mitochondria;Mitochondrial DNA;mtTF1 transcription factor;Mus;mutant;Mutant Strains Mice;Mutation;Newborn Infant;novel;novel therapeutic intervention;old mice;osteoblast differentiation;Osteoblasts;Osteocalcin;osteogenic;osteoprogenitor cell;overexpression;Oxidative Phosphorylation;Oxygen;Pathological fracture;Periosteal Cell;Phenotype;Play;postnatal;prevent;Process;Production;progenitor;Regulation;Role;Secondary to;Source;Stromal Cells;Testing;Time;transcription factor;Up-Regulation

PROJECT_TITLE: Mitochondria and TFAM in Osteoblast Biology


NIH_SPENDING_CATS: Aging;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LUBBOCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: NARRATIVE Neurotransmitter receptors belonging to the pentameric ligand-gated ion channel superfamily are involved in neuropsychiatric and neurological diseases, including Alzheimer’s and Parkinson’s disease, anxiety, epilepsy, depression, schizophrenia, and nicotine dependence. In humans there are more than 40 different subunits from which these channels assemble, each consisting of three different domains. Here, we propose to focus on one of these domains that is the most diverse between different subunits with the premise that characterizing in detail its structure and function at a molecular level will in turn allow the design specific drugs.

PI_NAMEs: JANSEN, MICHAELA  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;alpha helix;Alzheimer's Disease;Amino Acids;Anesthetics;Anti-Anxiety Agents;Anti-emetics;anti-epileptic agents;Anxiety;Anxiety Disorders;Architecture;Atherosclerosis;Attention;Binding;Biochemical;Biological Assay;Brain;burden of illness;Cations;Cause of Death;Cell Line;Cell membrane;Characteristics;Chimera organism;Choline;Cholinergic Receptors;Clinical;clinical effect;conformational conversion;Coupled;Cryoelectron Microscopy;Dementia;design;Diabetes Mellitus;disability;Disease;Drug Design;Drug Targeting;Electrophysiology (science);Environment;Epilepsy;esterase;Eukaryota;experimental study;extracellular;Extracellular Domain;Family;Family member;Foundations;Funding;Future;gamma-Aminobutyric Acid;Glycine;Heart Diseases;Homo;Human;Immobilization;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;insight;Investigation;Ion Channel;Ion Channel Gating;Knowledge;Length;Ligands;Link;maltose-binding protein;Mediating;Membrane Transport Proteins;Mental Depression;Methods;Modification;Molecular;Molecular Chaperones;Molecular Conformation;Muscle relaxants;Myasthenia Gravis;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuropsychiatric disorder;Neurotransmitter Receptor;Nicotine Dependence;novel;overexpression;Pain;Parkinson Disease;Peptides;Pharmaceutical Preparations;pharmacologic;Plant Resins;prevent;protein protein interaction;protein purification;Proteins;Publishing;receptor;Resistance;Role;Schizophrenia;Sepsis;Serotonin;Shapes;smoking cessation;Sodium Chloride;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;Surface;targeted treatment;Tertiary Protein Structure;Testing;therapeutic development;therapy design;Tissues;Transmembrane Domain;Western Blotting

PROJECT_TITLE: Probing the structure and function of the intracellular domain of cys-loop receptors

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Rapid de novo mRNA and protein synthesis are required for memory. We have identified immediate early genes that mediate the de novo response and here will elucidate, molecular, cellular and network processes that underlie normal memory as well as cognitive failure in human neurological disease.

PI_NAMEs: WORLEY, PAUL F (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Amyloid;Amyloid beta-Protein;Biological Markers;Brain;Cells;Clinical;Cognitive;Communities;Dependence;Deterioration;Disease;Down-Regulation;Excitatory Synapse;Failure;gain of function;Generations;Glutamate Receptor;Hippocampus;Homer 1a;Human;human subject;Immediate-Early Genes;in vivo Model;Individual;Information Storage;inhibitory neuron;insight;Interdisciplinary Study;Laboratories;loss of function;Mediating;Memory;Memory impairment;Memory Loss;Messenger RNA;Molecular;Monitor;mouse model;Nervous System Disorder;neural;Neurology;neuropathology;Neurosciences;novel;Parvalbumins;Pathology;Pathway interactions;Phase;prevent;Process;programs;Property;Protein Biosynthesis;Psychiatry;Research;response;Seizures;Synapses;synaptic function

PROJECT_TITLE: De novo Synthesis and Memory


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The mouth contains a large number of bacteria, the majority of which are not harmful. However, some non- harmful bacteria are also paradoxically required for harmful bacteria to fully cause periodontal disease. This study will investigate how changes in the white blood cells of the immune system during inflammation might modify interactions with the normally non-harmful bacteria allowing them to contribute to disease.

PI_NAMEs: KAY, JASON G (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acute;Bacteria;Cell Death;Cells;commensal bacteria;commensal microbes;cytokine;Cytoplasm;Data;Development;Disease;dysbiosis;Endocarditis;Environment;Exposure to;Goals;Growth;host-microbe interactions;Immune;immune activation;Immune system;in vivo;in vivo Model;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;Knowledge;Lesion;Leukocytes;Macrophage;Membrane;Microbe;microbiome;microorganism;Molecular;novel;Oral;Oral cavity;oral commensal;oral streptococci;pathobiont;pathogen;Pathway interactions;Periodontal Diseases;Periodontitis;Phagocytes;Phagosomes;Phenotype;Play;Porphyromonas gingivalis;prevent;Prevention strategy;Production;Publishing;Reactive Oxygen Species;receptor;recruit;Research;Resistance;response;Rodent;Role;Streptococcus;Streptococcus gordonii;Testing;tissue repair;Tissues;Vesicle

PROJECT_TITLE: A role for immune cell plasticity in commensal survival and escalation of inflammation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Precision Medicine;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Neoadjuvant chemotherapy (NACT) is administered to treat locally advanced invasive breast cancer by shrinking inoperable tumors, and to enable breast-conserving surgery. It offers the opportunity to evaluate tumor response to treatment in aggressive disease, and early identification of responders versus non-responders can aid the identification of patients who could benefit from additional trials. We propose to implement a novel quantitative multinuclear MRI protocol based on simultaneous acquisitions of sodium and proton MR fingerprinting data to develop an imaging biomarker model of early response of breast cancer to NACT.

PI_NAMEs: BROWN, RYAN ;MADELIN, GUILLAUME  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Alternative Therapies;alternative treatment;Anatomy;Bilateral;Biological Markers;Blood Vessels;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;breast imaging;Breast Magnetic Resonance Imaging;Breast-Conserving Surgery;cancer cell;Cancer Center;Carboplatin;Cell Death;cell injury;Cell Survival;Cellularity;Chemotherapy-Oncologic Procedure;Clinical;cohort;Computer software;Consumption;Contralateral Breast;contrast enhanced;Custom;Cyclophosphamide;Data;design;Diffusion Magnetic Resonance Imaging;Disease;Doxorubicin;Drug Kinetics;Early identification;Early treatment;extracellular;Fatty acid glycerol esters;FDA approved;Fingerprint;Gadolinium;Goals;Homeostasis;Image;imaging biomarker;imaging modality;improved;In complete remission;individualized medicine;insight;Ions;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammography;Maps;Measures;Membrane;Metabolic;Methods;Modeling;Monitor;MRI Scans;Neoadjuvant Therapy;Noise;novel;Nuclear;Paclitaxel;Pathologic;Patient Care;Patient Monitoring;Patients;pembrolizumab;Perfusion;Permeability;Physiologic pulse;Prediction of Response to Therapy;Prognosis;prognostic model;Property;Protocols documentation;Protons;radio frequency;responders and non-responders;response;Scanning;Signal Transduction;Sodium;Standardization;Structure;System;Testing;therapy outcome;Time;Tissues;Toxic effect;Treatment Protocols;treatment response;triple-negative invasive breast carcinoma;tumor;ultrasound;Variant;Water

PROJECT_TITLE: Multinuclear MRI to Monitor Breast Cancer Therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative This proposed research will further define the molecular mechanisms involved in herpesvirus infection using the prototypic human herpesvirus herpes simplex virus 1 (HSV-1). Herpesviruses cause significant disease and morbidity within the human population ranging from asymptomatic infections and blindness to life- threatening illness such as encephalitis and cancer. The proposed research may result in the identification of new prophylactics or therapeutics for herpesviruses that will lessen the pathologies associated with viral infection.

PI_NAMEs: CONNOLLY, SARAH A.;LONGNECKER, RICHARD M (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: arm;Binding;Biochemical;Biological Assay;Blindness;C-terminal;Cancer Patient;Cell Culture Techniques;Cell fusion;Cell membrane;Cell surface;Cells;Chimera organism;Chimeric Proteins;Clinical;Coiled-Coil Domain;Complex;Cryoelectron Microscopy;Cytoplasmic Tail;Data;design;Disease;Encephalitis;Evolution;Experimental Designs;experimental study;Family;Family member;genetic approach;genital herpes;Glycoproteins;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;HIV;HIV Infections;HIV/AIDS;Human;Human Herpesvirus 4;Human Herpesvirus 8;In Vitro;Individual;Infection;insight;Left;Lesion;Life;Malignant Neoplasms;Maps;Mediating;Membrane;Membrane Fusion;Methodology;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;Mutagenesis;mutant;Mutation;Natural Selections;Nature;novel;novel strategies;Pathology;Penetration;Play;Population;Prevention approach;Process;prophylactic;protein protein interaction;Proteins;prototype;Publishing;PVRL1;Reagent;receptor;Research;Risk;Role;Saimiriine herpesvirus 1;Serial Passage;Simplexvirus;Site;Site-Directed Mutagenesis;Structure;Therapeutic;tool;Transmembrane Domain;Viral;Virus;Virus Diseases;virus envelope;Virus-Induced Membrane Fusion;Work

PROJECT_TITLE: Mechanism of Herpes Simplex Virus (HSV) Induced Membrane Fusion

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research will determine the potential efficacy and safety of bacteriophages in mitigating the risks of multidrug-resistant organism (MDRO) colonization in the hematopoietic cell transplant population and preventing MDRO infections, an emerging public health threat. Thus, the proposed research is relevant to the part of NIH-NIAID’s mission that pertains to acquiring new knowledge and conducting applied research to understand, develop, and translate interventions that prevent the occurrence of MDROs.

PI_NAMEs: EL HADDAD, LYNN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Antibiotics;antimicrobial;Applied Research;Bacteremia;Bacteria;Bacterial Infections;bacteriome;Bacteriophages;Bioinformatics;biomarker identification;Biometry;Blood;Blood specimen;Bone Marrow;Buffers;career;Caudovirales;Centers for Disease Control and Prevention (U.S.);chemotherapy;Clinical Data;Communicable Diseases;cytokine;Data;design;Development;efficacy testing;Environment;Equilibrium;Evaluation;experience;experimental study;Fatal Outcome;Feces;fighting;Future;gastrointestinal;germ free condition;Germ-Free;Goals;graft vs host disease;gut colonization;gut microbiome;gut microbiota;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;host-microbe interactions;Human;Immune response;Immune system;immunodeficiency;improved;improved outcome;in vivo;in vivo Model;Incidence;Individual;Infection;infectious disease model;Inflammation;Inflammatory Response;innovation;insight;Intervention;Knowledge;Larva;microbiome;microbiome analysis;Microvirus;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;multi-drug resistant pathogen;Mus;National Institute of Allergy and Infectious Disease;normal microbiota;Outcome;pathogen;Pathology;Patient-Focused Outcomes;Patients;Population;prevent;Public Health;Quality of life;RAG1 gene;Randomized;reconstitution;Research;Research Personnel;Research Project Grants;Research Proposals;restoration;Risk;risk mitigation;Role;Safety;Sampling;Scheme;Sepsis;skill acquisition;Sterility;stool sample;synergism;Testing;Therapeutic;Time;Training;Translating;Transplant Recipients;Transplantation;United States National Institutes of Health;Vancomycin resistant enterococcus;Virus;Wild Type Mouse;Work;World Health Organization

PROJECT_TITLE: Bacteriophages as Modulators of Bacterial Colonization

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Obesity increases incidence and severity of asthma, but the underlying mechanisms remain unclear. This study will investigate the role of increased insulin, which is common in obese individuals, in obesity-related asthma, and identify the mechanisms by which insulin alters the function and architecture of nerves in lungs. Our results will help identify novel targets for prevention and treatment of obesity-related asthma, benefiting millions of patients while reducing treatment costs.

PI_NAMEs: FRYER, ALLISON DEBORAH;NIE, ZHENYING  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Acute;afferent nerve;Afferent Neurons;airway epithelium;airway hyperresponsiveness;Animals;Anti-Cholinergics;Architecture;arm;Asthma;asthmatic;Bronchoconstriction;Bronchodilator Agents;Chimeric Proteins;cholinergic;Computer Assisted;Data;density;Disease Management;effective therapy;Epithelium;Goals;Health Care Costs;Hospitalization;Human;Hyperinsulinism;In Vitro;in vivo evaluation;Incidence;Inhalation;innovation;Insulin;Insulin Receptor;Light;Link;Lung;Measures;Mediating;Medicine;Methods;Molecular;Mus;Muscarinic M2 Receptor;Muscarinic M3 Receptor;Muscle Contraction;Nerve;nerve supply;neural;Neuronal Dysfunction;Neurons;neuroregulation;Neurotransmitters;new therapeutic target;novel;Obese Mice;obese patients;obese person;Obesity;obesity treatment;obesity-associated asthma;optogenetics;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Prevalence;prevent;Prevention;Quality of life;Rattus;receptor expression;reconstruction;Reflex action;Research;respiratory smooth muscle;Role;Sensory;Serotonin;Severities;Severity of illness;Signal Pathway;Signal Transduction;Smooth Muscle;Streptozocin;Structure;Symptoms;Techniques;Testing;Tissues;Trachea;Transgenic Mice;Treatment Cost;Vagotomy;Vagus nerve structure

PROJECT_TITLE: Insulin increases nerve-mediated bronchoconstriction in obesity-related asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research project will develop a novel regimen by which oncolytic virotherapy can be used as a potent immunological adjuvant to improve the efficacy of CAR T cell therapy against solid tumors. We have shown that CAR T cells loaded ex vivo with oncolytic virus (OV) induces a population of CAR T cells with dual specificity against the CAR target tumor antigen and oncolytic viral antigen(s) in vivo, which have improved memory-like differentiation, persistence, and greatly enhanced anti-tumor potency compared to conventional CAR T cells. In this proposal, we will now 1). define the molecular mechanisms of DS CAR T cell generation; 2). generate DS CAR T cells with TCR specificity against either viral, or tumor associated, antigens and 3). optimize the persistence/longevity/activity of DS CAR T cells through novel boosting strategies, leading to implementation of fully systemic protocols for the combination of CAR T cells with OV which do not require any access to tumors.

PI_NAMEs: VILE, RICHARD G. (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Adjuvant;anti-tumor immune response;Antigen Targeting;Antigens;CAR T cell therapy;CD19 gene;CD8B1 gene;Cellular biology;chimeric antigen receptor T cells;Combined Modality Therapy;cytotoxic;cytotoxicity;Data;Epitopes;Frequencies;Generations;Goals;Hematopoietic Stem Cell Transplantation;Immune checkpoint inhibitor;Immunologic Adjuvants;improved;in vivo;Infiltration;Inflammatory;Interferon alpha;leukemia;Longevity;Mediating;Memory;Molecular;Mus;Nature;neoplastic cell;novel;novel strategies;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Pathway interactions;Patients;Phenotype;Physiological;Population;Preclinical Testing;preconditioning;prevent;programs;Proliferating;Protocols documentation;recruit;Recurrence;Regimen;Reovirus;research clinical testing;Research Project Grants;response;Rest;Route;Site;Solid Neoplasm;Specificity;subcutaneous;T cell differentiation;T cell therapy;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Tissues;trafficking;Translations;tumor;Tumor Antigens;tumor growth;tumor microenvironment;tumor-immune system interactions;Vesicular stomatitis Indiana virus;Viral;Viral Antigens;Viral load measurement;Virus;Virus Diseases

PROJECT_TITLE: Re-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors.

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SARASOTA

ORG_NAME: ROSKAMP INSTITUTE, INC.

PHR: PERSONNEL JUSTIFICATION Joseph Ojo, Ph.D. (Principal Investigator, 3 calendar months per year) is a molecular and cellular biologist who has many years of experience with performing histopathological analyses of brain tissue. He has been involved in the development and characterization of a variety of mouse models of TBI, AD, PD and comorbid conditions, and performing molecular level analyses with novel omic technologies. He has been a key investigator on the original and current contracts with Dr. Crawford and along with Dr Benoit Mouzon and Andrew Pearson generated the preliminary data described in this proposal. Dr. Ojo will continue to work alongside Dr. Crawford in directing all aspects of this project and provide supervision and full oversight on the overall approach, mTBI animal modeling, histopathological and molecular analyses, and data interpretation for the experiments outlined in this application. He will also be responsible for overseeing all aspects of animal manipulation, injuries, and treatment, ensuring that the projects are executed in a timely fashion. He will also perform some of the histopathological and biochemical assessments in the animal models described in the proposal. Fiona Crawford, Ph.D. (co-Investigator, 0.6 calendar months effort per year at no cost) is a molecular geneticist and biologist with over 30 years of experience in researching neurological conditions including investigation of molecular and clinical aspects of Alzheimer’s disease (AD) and Traumatic Brain Injury (TBI). Dr. Crawford is the President and CEO of the Roskamp Institute and she directs the TBI Research program and polyomics programs at the Roskamp Institute. She will provide supervision on the overall approach, mTBI animal modeling, pathological studies, and data interpretation. In particular, she will interact with all the team members listed on this application and work along with Dr Ojo in providing oversight as they implement the work proposed in this application, including regular communication with the expert consultants (Loane and Bioinformatics Team). Andrew Pearson M.S. (Research Associate, 6 calendar months in Years 1 and 2) is the Roskamp Institute TBI Research Team’s Research Associate. He is experienced in animal handling and surgical procedures, as well as histopathological characterization, molecular analyses, (such as western blotting and ELISA), glial isolation, ex vivo cultures and omic analyses. He will assist in all experimental injury procedures and treatment schedules and conduct histopathological/molecular analyses with the supervision of Dr. Ojo. OTHER EXTERNAL COLLABORATORS David Loane, Ph.D. (Consultant to the project, at $2500 in Year 2) leads a multi-disciplinary research team dedicated to studying the complexities of traumatic brain injury (TBI), neuroinflammation and tissue repair. His research investigates the activation status and functional role of resident microglia and infiltrating immune cells in the injured brain, and how they contribute to ongoing neurodegenerative processes that promote long-term neurological dysfunction after brain trauma. The primary focus of his recent work has focused on elucidating the molecular mechanisms that regulate microglial/macrophage function with the goal of manipulating these cells to attenuate destructive pro-inflammatory responses, and promote protective pro-repair responses. Thus, his experience fits perfectly with the goals and direction of this proposed study. Dr Loane has experience in using a variety of animal models of TBI (including the Cre-LoxP model and the well described Hexb-creER mice) for flow functional genomic, neuropathology and flow cytometry based studies. He is well trained in brain neuroimmune biology, neuropathology, and molecular & cellular neurobiology, including single- population RNA sequencing (RNA-seq), and has been studying gene and protein expression profiles and their related functions in resident microglia and infiltrating immune cells over 15yrs. Specifically, he will serve as a consultant working with Dr. Ojo to advice on the use of the Cre-LoxP model, tamoxifen treatment paradigm, microglia ablation technique, and interpretation of microglia cell histopathology and RNAseq data generated from our models.

PI_NAMEs: OJO, JOSEPH O (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Ablation;AD transgenic mice;Address;Age;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-4;Attenuated;Automobile Driving;Autopsy;axon injury;behavioral outcome;Biochemical;Biochemical Markers;Bioinformatics;Biology;Brain;Brain Injuries;brain tissue;Calendar;Cells;Cellular Neurobiology;Chronic;Clinical;Clinical Trials;Communication;comorbidity;Contracts;cost;Cre-LoxP;Data;Data Analyses;Data Set;Dedications;density;Deposition;Development;disability;Disease associated microglia;Doctor of Philosophy;effective therapy;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;Etiology;Event;experience;experimental study;exposed human population;Exposure to;Failure;Flow Cytometry;functional genomics;Future;Gene Expression;Gene Modified;Genes;Genetic;genetic manipulation;genetic risk factor;genetic signature;Genetic Transcription;Genotype;Goals;Health;Heterogeneity;Histopathology;Human;human model;human study;hyperphosphorylated tau;immune cell infiltrate;Individual;Inflammatory;Inflammatory Response;injured;Injury;Interdisciplinary Study;Investigation;Lesion;longitudinal analysis;longitudinal design;Longitudinal Studies;Macrophage;Mediating;member;Microglia;mild traumatic brain injury;Modeling;Molecular;Molecular Analysis;Molecular Neurobiology;mouse model;Mus;Nerve Degeneration;neurodegenerative phenotype;Neuroglia;Neuroimmune;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurons;neuropathology;new therapeutic target;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient population;pharmacologic;Phenotype;Play;Population;Postdoctoral Fellow;preclinical study;Principal Investigator;Procedures;Process;programs;prospective;Protein Biochemistry;protein expression;Protein Isoforms;Rationalization;repaired;Reporting;Research;Research Design;Research Personnel;response;Risk;Risk Factors;Role;Sampling;Severities;Supervision;Synapses;Tamoxifen;tau Proteins;tau-1;Tauopathies;TBI treatment;Techniques;Technology;Therapeutic;Therapeutic Intervention;Time;tissue repair;Tissues;Training;transcriptome sequencing;transcriptomics;transgenic model of alzheimer disease;Traumatic Brain Injury;Treatment Protocols;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Influence of APOE4 genotype on microglial pathobiology and tau pathology after repetitive mTBI

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative. Missense variants in the K+ channel gene KCNT1 increase K+ flow through mutant channels and cause developmental epileptic encephalopathies. We aim to gain an understanding of the neuronal cell types that are most strongly affected by the variants and how they contribute to disease phenotypes in order to target further studies and potential treatments.

PI_NAMEs: WESTON, MATTHEW C (contact)

PROJECT_TERMS: Action Potentials;Address;Affect;Area;Biological Assay;Biophysics;cell type;Cells;childhood epilepsy;Data;developmental epileptic encephalopathy;Disease;disease phenotype;disease-causing mutation;Epilepsy;epileptiform;excitatory neuron;Functional disorder;gain of function;Generations;Genes;Genetic;Genetic study;genetic variant;Health;Human;Human Genetics;Image;Impairment;improved;In Vitro;in vivo;in vivo imaging;in vivo Model;inhibitor;inhibitory neuron;Ion Channel;Kinetics;Knockout Mice;Knowledge;Lead;Link;Measures;Mediating;Membrane;Modeling;Molecular;mouse model;Mus;mutant;network dysfunction;neural;Neuroglia;neuronal excitability;neuronal patterning;Neurons;neurophysiology;Pathogenicity;Pathologic;Patients;Pattern;Physiological;Play;Population;Potassium Channel;Precision therapeutics;prevent;Publishing;Refractory;Regulation;Research;Role;Seizures;System;Testing;Translating;Variant

PROJECT_TITLE: Cell Type-Specific Roles of the Na-Activated K Current in KCNT1-Related Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Inflammation during pregnancy, such as in response to maternal viral infection, is increasingly recognized as a risk factor for neurodevelopmental disorders in the offspring, yet the developmental pathways whereby it alters fetal brain development and leads to sustained neuroinflammation across the offspring lifespan are not fully understood. The goal of this project is to characterize, using a mouse model, a novel mechanism by which gestational inflammation disrupts fetal blood-brain barrier formation and function, leading to adult offspring neurovascular dysfunction that is observed in many neurological disorders. From an etiological standpoint, this pre-clinical proposal will define novel cellular and molecular pathways involved in self-perpetuating, life-long effects of prenatal inflammation, shedding light on the mechanisms by which it is causally linked to vascular disruptions in neurodevelopmental disorders.

PI_NAMEs: BONNIN, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Adult Children;age related neurodegeneration;Behavior;Behavioral;Biological Assay;Blood - brain barrier anatomy;blood product;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain parenchyma;celecoxib;Cell Proliferation;Cells;cerebrovascular;Chronic;conditional knockout;Consensus;cyclooxygenase 2;Data;Development;Dinoprostone;Disease;Encephalitis;Endothelial Cells;Endothelium;Etiology;ex vivo perfusion;experience;Exposure to;Extravasation;fetal;fetal blood;Fetal Development;Fetus;Functional disorder;Gadolinium;Genes;Genetic;glial activation;Goals;Hippocampus;Histologic;Histology;Immune;immune activation;in utero;In Vitro;in vivo;Infiltration;Inflammation;Inflammation Mediators;Knock-out;knockout gene;Knockout Mice;Knowledge;Life;life span;Light;Link;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;Methods;Microglia;mimetics;Modeling;Molecular;molecular pathology;mouse model;Mus;Myeloid Cells;Nervous System Disorder;Neurodevelopmental Disorder;neuroinflammation;neuropathology;neurovascular;novel;offspring;Outcome;Pathway interactions;Perfusion;Pericytes;Permeability;Phenotype;Poly I-C;postnatal;pre-clinical;Pregnancy;pregnant;prenatal;prevent;PTGS2 gene;Reporter;Research;Research Personnel;response;Risk;Risk Factors;Schizophrenia;Structure;System;systemic inflammatory response;Techniques;Testing;Tight Junctions;Time;Tracer;Vascular Diseases;Viral;Virus Diseases;young adult

PROJECT_TITLE: Prenatal inflammation disrupts blood-brain barrier development and long-term function.

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Alzheimer’s disease, Parkinson’s disease and related age-dependent neurodegenerative diseases are common but have few effective treatments options. Here we suggest a novel mechanism of disease: anastasis. In anastasis, cells that are destined to die are rescued and become toxic to surrounding cells, promoting disease progression. If successful, our work will suggest possible new types therapies for Alzheimer’s disease and related disorders and may inform treatment development for the many other neurological disorders in which cell death pathways become dysregulated.

PI_NAMEs: FEANY, MEL B (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age related neurodegeneration;Aging;aging brain;aging related;Alexander Disease;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;Animal Model;Astrocytes;Biochemical;Brain Stem;Caspase;Cell Culture Techniques;Cell Death;Cells;Cessation of life;Clinical;cytokine;Data;design;Development;Disease;Disease Progression;Drosophila genus;dysmyelination;effective therapy;fly;Genes;Genetic;genetic analysis;Genetic Screening;genome-wide;Glial Fibrillary Acidic Protein;Gliosis;Greek;human stem cells;in vivo;Individual;Induced Neurons;infancy;Inflammatory;Inhibition of Apoptosis;Injury;Intermediate Filament Proteins;Knowledge;life span;Mammalian Cell;Mammals;Mediating;Modeling;Morphology;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron loss;Neurons;neurotoxicity;novel;Parkinson Disease;Pathologic;Pathway interactions;Play;Process;protein aggregation;Rattus;Recovery;Role;Source;Specificity;Spinal Cord;stem cell model;Syndrome;System;tau Proteins;Tauopathies;Testing;therapy development;Tissues;Toxic effect;Transgenic Mice;Work

PROJECT_TITLE: Anastasis in age-related neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Chronic pain caused by nerve injury and neuropathy is a major clinical problem and remains difficult to treat. In this proposal, we will investigate the molecular and signaling mechanisms involved in the regulation of pain transmission. Findings from this proposal will provide new insight into the molecular mechanisms of chronic pain and will help the development of new therapies for treating chronic pain.

PI_NAMEs: CHEN, SHAO-RUI ;PAN, HUI-LIN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Afferent Neurons;Anions;antagonist;Behavioral;Biochemical;C-terminal;Cations;Cell Size;Cell Volumes;chemotherapy;chemotherapy induced neuropathy;chronic neuropathic pain;chronic pain;chronic pain management;chronic painful condition;Clinical;conditional knockout;Data;Development;dorsal horn;Down-Regulation;Family member;Gene Delivery;Glutamate Receptor;Glutamates;Goals;Hypersensitivity;In Vitro;in vivo;Induced Neurons;innovation;insight;interdisciplinary approach;knock-down;Knowledge;Leucine-Rich Repeat;Link;Mediating;Molecular;N-Methyl-D-Aspartate Receptors;nerve injury;Nervous System Disorder;Neuronal Plasticity;Neurons;Neuropathy;Nociception;novel;novel therapeutics;overexpression;Paclitaxel;Pain;pain chronification;pain model;painful neuropathy;Phenotype;Pilot Projects;Play;Posterior Horn Cells;presynaptic;Proteins;receptor coupling;Regulation;restraint;Role;Sensory;Signal Transduction;Small Interfering RNA;Spinal;Spinal Cord;Spinal Ganglia;Synapses;Synaptic plasticity;Testing;Therapeutic;trafficking;Transgenic Mice;transmission process;Traumatic Nerve Injury

PROJECT_TITLE: Molecular Determinants of Synaptic Plasticity in Chronic Pain

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Sleep Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This is a new application for a training program focused on increasing the number of underrepresented minorities in the physician-scientist workforce. The training program is multidisciplinary and aims to provide rigorous training in basic science discovery, clinical/translational initiatives, dissemination/implementation science, and health disparities research. Based on an exceptional training platform guided by a group of highly successful faculty, the primary focus will to transform underrepresented minority physicians into independent, successful, high-impact academic researchers in the fields of Pulmonary and Sleep Medicine.

PI_NAMEs: PUNJABI, NARESH M (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Lung;Minority;Research;Sleep

PROJECT_TITLE: Promoting Under-Representative Minorities in Pulmonary and Sleep Research (PURPOSE)


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sepsis

ORG_CITY: BURLINGAME

ORG_NAME: COHERE-MED, INC.

PHR: Narrative Sepsis is the leading cause of in-hospital mortality in the US and early detection and management of sepsis can dramatically improve patient outcomes. Sepsis Watch is a deep learning sepsis detection and management platform that was developed and validated in the emergency department (ED) at one hospital within Duke Health and preliminary data demonstrates significant reductions in mortality. We will enhance and optimize Sepsis Watch to accurately detect sepsis across multiple hospitals across the US, externally and temporally validate Sepsis Watch across locations, and extend Sepsis Watch to ED, general ward, and intensive care unit settings to transform Sepsis Watch into a scalable solution that can improve sepsis outcomes across the country.

PI_NAMEs: PATEL, MANESH R (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Accident and Emergency department;adjudication;Adoption;Adult;Area;Benchmarking;Caring;Cessation of life;Clinical;clinical care;commercialization;comorbidity;cost;Country;Data;Data Analyses;Data Element;data ingestion;data quality;Data Set;deep learning;demographics;design;Detection;Diffusion;Early Diagnosis;Early identification;Economic Burden;economic impact;economic outcome;Electronic Health Record;electronic health record system;Ensure;Event;experience;Feedback;flexibility;General Ward;Geographic Locations;Geography;Health;Health system;Hospital Mortality;Hospital Units;Hospitals;Hour;implementation barriers;implementation facilitators;improved;Ingestion;Inpatients;Intensive Care Units;Intervention;iterative design;Learning;Location;Machine Learning;machine learning model;Measurement;Modeling;Morbidity - disease rate;mortality;Outcome;Output;patient population;Patient-Focused Outcomes;Performance;Pharmaceutical Preparations;Phase;Positioning Attribute;predictive modeling;Process;Publishing;quality assurance;Records;Running;Sepsis;Septic Shock;Site;Small Business Technology Transfer Research;State Hospitals;Subgroup;Surface;System;Technology;Time;United States;University Hospitals;Update;Validation;Variant;Vendor;ward

PROJECT_TITLE: Solving Sepsis: Early Identification and Prompt Management Using Machine Learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases;Tuberous Sclerosis

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE Virtually all patients with Down syndrome (DS) develop Alzheimer’s disease-like neuropathology including amyloid beta plaque deposits and neurofibrillary tangles, but the mechanisms responsible for this are unknown. Recent studies indicated that an imbalance between the amount of proteins produced and degraded inside the neurons can results in dysfunction and death. In the current project we will use DS brain tissues and models of DS to investigate how early changes within the nerve cells can lead to the onset and progressive accumulation of this neuropathology.

PI_NAMEs: PRATICO, DOMENICO  (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyloid;Animal Model;Autopsy;Behavior;behavioral impairment;Biochemical;Birth;Brain;Brain Pathology;Brain region;brain tissue;Catabolism;Cell Death;Cell Physiology;Cells;Cessation of life;Chromosome 21;Chromosomes;Congenital Disorders;Data;Defect;Dementia;Deposition;Development;Down's Syndrome;Event;FRAP1 gene;Functional disorder;gene product;Gene Proteins;Health;Human Chromosomes;Hyperactivity;in vivo Model;Incidence;Individual;Knowledge;Link;Literature;Modeling;mouse model;mouse Ts65Dn;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;novel;novel therapeutics;Organ;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Phenotype;Physiological;Play;programs;Protein Biosynthesis;protein degradation;Protein Precursors;Proteins;proteostasis;proteostasis loss;Publishing;Research;Role;Secondary to;secretase;Senile Plaques;Signal Pathway;Signal Transduction;Synapses;Syndrome;System;tau aggregation;tau Proteins;therapeutic target;tool;trafficking;Trisomy;Tuberous Sclerosis;United States;virtual

PROJECT_TITLE: Proteostasis dysregulation and the development of Alzheimer's-like neurodegeneration and dementia in Down syndrome

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Pediatric

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Residential treatment is the most restrictive, intensive, and costly setting available for adolescents with severe emotional and behavioral healthcare needs; yet, 78% of adolescents do not sustain treatment gains once they transition to the home environment. This study aims to promote treatment gain maintenance by testing a web- based parent training augmented with virtual clinician facilitated discussion groups (referred to as PWRT) to prepare parents for the reintegration of their adolescents in the home. PWRT has been specifically designed to meet the needs of parents, adolescents, and residential treatment facilities by moving intervention outside of traditional delivery settings and into the home, increasing parent engagement, access to care, and sustaining residential treatment gains.

PI_NAMEs: HERBELL, KAYLA  (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Admission activity;Adolescent;Adolescent Behavior;Age;Aggressive behavior;Behavior;Behavioral;behavioral health;Biological;Caregivers;Case Series;Child Rearing;Code;Collaborations;Communities;community partners;Complex;Consent;cost;County;Coupled;Data;Data Collection;design;Discipline;Dose;Education;Educational process of instructing;effectiveness trial;Elements;Emotional;Enrollment;evidence base;Evidence based intervention;Exercise;experience;externalizing behavior;Face;Family;feasibility testing;follow-up;Fostering;Frequencies;Functional disorder;Future;Goals;Health Services Accessibility;Healthcare;Home;Home environment;Intervention;Jail;Maintenance;National Institute of Mental Health;Online Systems;Outcome;parenting intervention;Parents;Patient Self-Report;Population;prevention service;Problem behavior;programs;Randomized;recruit;Reporting;Research Personnel;Residential Treatment;retention rate;Risk Factors;Sampling;satisfaction;Self Efficacy;Self-Injurious Behavior;skills;Social support;Stigmatization;Structure;Surveys;Technology;Testing;Time;treatment as usual;uptake;videoconference;virtual;Voice

PROJECT_TITLE: Optimizing residential treatment gains for adolescents through tailored behavioral parent training

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Kidney Disease;Rare Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative: Localized ablation is a recommended treatment for T1a renal cancers and increasingly used as a non-surgical treatment option. Detection of cancer recurrence by CT or MRI (the current clinical standard) can be problematic due to patient contraindications, low temporal resolution, and cost. We propose multi-modality contrast- enhanced ultrasound to detect recurrent renal cancer following ablation and propose to compare its performance to contrast-enhanced cross-sectional imaging in a fully powered clinical study.

PI_NAMEs: EISENBREY, JOHN  (contact);TRABULSI, EDOUARD JOHN;WALLACE, KIRK DENNIS

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adoption;Adverse event;Agreement;American;anatomic imaging;Blinded;Blood Vessels;calcification;Cancer Detection;cancer recurrence;Cicatrix;Clinical;clinical application;Clinical Research;clinically actionable;contrast enhanced;contrast enhanced computed tomography;Contrast Media;Contrast Sensitivity;cost;Data;Data Set;Deposition;design;Detection;Development;Diagnosis;dosage;Early identification;Encapsulated;experience;Fat necrosis;follow-up;Follow-Up Studies;Gases;Granulation Tissue;Hepatic;Image;Image Analysis;imaging approach;imaging detection;imaging modality;Imaging Techniques;improved;Incidence;Inflammation;Inflammatory;Institution;Kidney;kidney cortex;Lipids;Longterm Follow-up;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Microbubbles;Modality;Monitor;Multimodal Imaging;multimodality;Operative Surgical Procedures;Pathology;Patient Recruitments;Patients;Performance;Pilot Projects;portability;Predictive Value;preservation;Proteins;Protocols documentation;quantitative imaging;radiologist;Reader;real-time images;Recommendation;Recurrence;Recurrent disease;Reference Standards;Relapse;Renal Carcinoma;Renal Cell Carcinoma;Renal function;Residual state;Resolution;Retreatment;Safety;Sample Size;screening;sensor;Site;Specificity;standard of care;surveillance imaging;Techniques;temporal measurement;Testing;Time;Tissues;tumor;Ultrasonography;ultrasound

PROJECT_TITLE: Multi-modality detection of RCC Recurrence Post Ablation

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE This proposal emphasizes on evaluating the therapeutic potential use of induced pluripotent stem cell derived neural stem cells to deliver microRNA to advanced brain tumors. Once validated, this therapeutic strategy has a great potential to be integrated into the clinical care regimen for brain tumor therapy.

PI_NAMEs: BHERE, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adult;Aftercare;Award;Beds;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Cell Differentiation process;cell growth;Cell Line;Cell Proliferation;Cells;Central Nervous System Diseases;chemotherapy;Clinical;clinical care;clinical translation;Data;Development;Diagnosis;Disease;Drug Delivery Systems;effective therapy;Encapsulated;Engineering;Ensure;Epidermal Growth Factor Receptor;Etiology;Excision;exosome;Extracellular Matrix;Flow Cytometry;fluorescence imaging;Ganciclovir;Glioblastoma;Goals;Growth;image guided;imaging agent;Immune;immune activation;immune clearance;Immune response;Immune system;Immunity;Implant;implantation;In Vitro;in vivo;induced pluripotent stem cell;Kinetics;Knowledge;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mentors;MicroRNAs;migration;Modeling;Molecular;mouse model;Mus;neoplastic cell;nerve stem cell;novel;Operative Surgical Procedures;Pathway interactions;Patients;Phase;Positron-Emission Tomography;Primary Brain Neoplasms;Prognosis;promoter;Proto-Oncogene Proteins c-akt;Publishing;Radiation therapy;Regimen;Resected;response;restoration;Role;Safety;Signal Transduction;Simplexvirus;Small RNA;STAT3 gene;stem cells;success;suicide gene;Surgically-Created Resection Cavity;Survival Analysis;synergism;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapeutic miRNA;therapy development;Thymidine Kinase;Time;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;Tumor Debulking;tumor microenvironment;Tumor Volume;Up-Regulation;Validation

PROJECT_TITLE: microRNA therapies for advanced brain tumors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Most gene changes associated with the increased clinical outcomes observed in African American men with prostate cancer are found in the tumor stroma. Advanced glycation end products (AGEs) are reactive metabolites that are associated with the interrelated socioeconomic, demographic and environmental factors that drive cancer disparity. These studies will assess if the AGEs associated with cancer disparity have distinct molecular consequences on the tumor stroma found in African American men and determine if African American men are exposed to higher levels of exogenous sources of AGEs.

PI_NAMEs: TURNER, DAVID PAUL (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Acceleration;Adenocarcinoma;Advanced Glycosylation End Products;African American;African ancestry;age acceleration;aging process;Allografting;Basic Science;Binding;biochip;Biological;Biological Availability;Black race;Cancer Burden;cancer cell;cancer health disparity;Cancer Patient;cell growth;Cells;Chemicals;Chronic;Circulation;Clinical;Coculture Techniques;cohort;Cohort Studies;Collagen;Communities;Consumption;Data;Demographic Factors;Deposition;Development;Diet;dietary;Dimerization;Disease;Disease Progression;Down-Regulation;ECM receptor;Education;Elements;Energy consumption;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Epithelial Cells;Epithelium;Ethnic Origin;Exposure to;Extracellular Matrix;Fibroblasts;Food Chain;Foundations;fruits and vegetables;functional decline;Future;Genes;genetic regulatory protein;genome analysis;glycation;Growth;health disparity;health inequalities;high risk;Human;Immune;in vitro Model;in vivo;Incidence;Individual;Ingestion;innovation;Intake;Integrins;Intervention;Invaded;Laminin;Louisiana;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Matrix Metalloproteinases;Mediating;Membrane;men;Metabolic;Metabolism;Microfluidics;migration;MMP9 gene;Modeling;Molecular;molecular site;mortality;Mus;North Carolina;Not Hispanic or Latino;novel;Obesity;Oncogenic;Organ;Outcome;outcome disparities;Participant;Pathway interactions;Patients;Peptide Hydrolases;Peptides;pharmacologic;Play;Population;Populations at Risk;Preventive;programs;prostate cancer cell line;prostate cancer risk;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Prostatic Intraepithelial Neoplasias;Prostatic Neoplasms;racial difference;receptor for advanced glycation endproducts;reconstitution;Regulation;Research;research study;Resources;Risk Factors;RNA Splicing;Role;Serum;Signal Transduction;Socioeconomic Factors;Source;spheroids;Spliced Genes;sugar;Testing;Therapeutic;Tissues;TNF gene;transcriptome sequencing;Treatment Protocols;treatment strategy;tumor;Tumor Biology;tumor growth;tumor progression;tumorigenic;Variant;Visualization;Vulnerable Populations;wasting;whole genome;Work;Xenograft Model

PROJECT_TITLE: Cause and Effect Relationships Between Glycation and the Ancestry Specific Tumor Stroma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]