ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE  Alcohol use disorder (AUD) is a chronic, relapsing, prevalent, disabling and fatal disorder for which new drug targets and neurobiological insight are needed. Guided by novel preliminary data, this multidisciplinary project tests the overarching hypothesis that decreasing dorsal striatal phosphodiesterase 10A (PDE10A) type 2 activity in indirect medium spiny neurons (MSN) can reduce compulsive drinking. Our assembled team seeks to fill key gaps in our neurobiological, pharmacological and genetic understanding of the role of PDE10A isoforms in striatal MSN circuits and compulsive drinking that will shed light on the potential impact of novel translatable PDE10A inhibitors to treat AUD.

PI_NAMEs: ZORRILLA, ERIC P (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Adenylate Cyclase;Affective;Affinity Chromatography;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol use disorder;American;Behavior;Behavioral;Behavioral Genetics;Chronic;Corpus striatum structure;cost;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Data;differential expression;Disabling;Disease;Dorsal;Dose;drinking;drinking behavior;economic behavior;economic evaluation;Enzymes;Ethanol;Extinction;Gene Activation;Genes;Genetic;genetic variant;Guanylate Cyclase;Human;Human Genetics;Immediate-Early Genes;inhibitor;insight;knock-down;Knock-out;Link;lipophilicity;loss of function;LoxP-flanked allele;Membrane;Mental disorders;Modeling;Molecular;mortality;Motor;motor behavior;multidisciplinary;Neurobiology;neuronal circuitry;Neurons;new therapeutic target;novel;Nucleus Accumbens;Outcome;Pathway interactions;Persons;pharmacologic;phosphoric diester hydrolase;Protein Isoforms;psychogenetics;putamen;Rattus;reinforcer;Relapse;Resistance;Ribosomes;RNA Splicing;Role;rumination;Self Administration;small hairpin RNA;Social Interaction;Testing;Therapeutic;Tissues;Translating;vapor;Variant;Viral;Work

PROJECT_TITLE: Dorsal striatal phosphodiesterase 10A and compulsive ethanol use

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: A major challenge for the VA lies in the provision of specialty services to the 50% of Veterans who require them, and one condition with a particular unmet need for specialty care is obstructive sleep apnea (OSA). Many Veterans are referred to community care providers to provide specialty access, but our preliminary data suggest these referrals can be costly and lead to delays in care. Using care for OSA as a model, our research seeks to inform the delivery of VA specialty services in a Veteran-centered, effective and efficient way. To do so, we will refine and pilot a program of virtual sleep consults to facilitate care within community based outpatient clinics. We will elicit perspectives from Veterans and health care providers to guide necessary adaptations to our program, and will pilot our intervention to obtain information essential to planning a definitive trial. We will also conduct nationwide cost and budget impact analyses to better understand costs of current practices, and project the costs of replacing community care referrals with VA-based services.

PI_NAMEs: DONOVAN, LUCAS MATTHEW (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Ambulatory Care Facilities;Award;budget impact;care providers;care systems;Caring;chronic care model;Communities;Community Healthcare;Consult;Consultations;cost;Data;Data Collection;Data Science;Decentralization;design;Diagnosis;Diagnostic;Distant;Drowsiness;Effectiveness;effectiveness testing;effectiveness/implementation trial;Enrollment;Equipment;experience;Face;feasibility testing;Future;Goals;Health;Health Personnel;Health Services Accessibility;high risk;implementation barriers;implementation science;Improve Access;improved;innovation;Intervention;intervention effect;Intervention Trial;Interview;Location;Measures;Medical center;medical specialties;Methodology;Modeling;multi-site trial;novel;Obstructive Sleep Apnea;Outcome;Outpatients;Pathway interactions;Patient Compliance;Patient-Focused Outcomes;Patients;Primary Care;Privatization;Procedures;Process;process evaluation;Program Effectiveness;programs;Provider;Qualitative Methods;Quality of Care;Quality of life;randomized trial;recruit;Reporting;Research;Research Activity;Resources;respiratory;Role;Rural Community;Rural Health;Services;Site;Sleep;Specialist;Symptoms;Testing;Training;Training Activity;treatment adherence;Treatment outcome;trial design;trial planning;Uncertainty;Veterans;virtual;virtual healthcare;virtual model;Visit;Work

PROJECT_TITLE: Redesigning Medical specialty Outpatient DELivery through virtual SLEEP care (REMODEL-SLEEP)

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Cardiac rehabilitation, an outpatient program that includes supervised exercise and cardiovascular risk factor education, is one of the most important therapies for patients with cardiovascular disease. Unfortunately, very few Veterans with cardiovascular disease enroll in cardiac rehabilitation programs. This proposal will evaluate Veterans’ individual barriers to attending cardiac rehabilitation with both surveys and interviews. Using this information, we will develop a behavioral intervention to encourage Veterans to enroll in outpatient cardiac rehabilitation programs. This intervention will be individually tailored to Veterans with the information- motivation-behavioral skills model, a theory of behavior change. We will test the tailored intervention with a proof-of-concept study in Veterans hospitalized with cardiovascular disease at the Veterans Affairs Tennessee Valley Healthcare System. This project is relevant to Veterans’ health because increasing enrollment in cardiac rehabilitation will decrease mortality and increase quality of life in Veterans with cardiovascular disease.

PI_NAMEs: BACHMANN, JUSTIN M (contact)

PROJECT_TERMS: acceptability and feasibility;Acute myocardial infarction;Address;behavior change;Behavior Therapy;Behavioral;Belief;Cardiac;Cardiac rehabilitation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career development;Caring;Clinical;Clinical Trials;clinically significant;cohort;Data;data integration;Development;Education;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Enrollment;Event;Exercise;experience;Five-Year Plans;formative assessment;Goals;Health;Health Services;Health Services Research;Healthcare Systems;Home;Hospitalization;implementation science;improved;Individual;innovation;insight;instrument;Intervention;intervention effect;Intervention Trial;Interview;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Link;Measures;Mental Depression;Methodology;Methods;Modeling;mortality;Motivation;Myocardial Ischemia;Nature;Nurses;Obesity;observational cohort study;outpatient programs;Outpatients;participant enrollment;Patient Participation;Patients;Prevalence;programs;psychosocial;Quality of Care;Quality of life;randomized, clinical trials;Recurrence;Research;Research Personnel;Risk Factors;Sampling;Self Efficacy;Services;skills;Social support;Specialist;Structure;success;Surveys;Tennessee;Testing;theories;therapy design;therapy development;Training;United States Department of Veterans Affairs;usability;Veterans;Veterans Health Administration

PROJECT_TITLE: Development of a Tailored Intervention to Increase Veteran Enrollment in Cardiac Rehabilitation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Individuals on the autism spectrum experience poor outcomes over the life course, including reduced life expectancy, high rates of co-occurring health conditions, poor healthcare access and quality, poor quality of life, and low rates of employment, independent living, and community engagement. In order to evaluate new and existing services targeted toward improving these outcomes, researchers and services providers need accessible, patient-centered, psychometrically sound, and pragmatic patient-reported outcome measures (PROMs) that have been tested in multiple real-world settings. The AutProm Toolbox, developed and evaluated in this proposal, will meet that need, enabling researchers and service providers to more effectively evaluate and implement services that improve the health, function, and wellbeing of adults on the autism spectrum.

PI_NAMEs: NICOLAIDIS, CHRISTINA M (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: adult with autism spectrum disorder;Anger;Anxiety;Assessment tool;autism spectrum disorder;autistic;Caregivers;Characteristics;cognitive interview;cohort;Communities;community based participatory research;community engagement;community organizations;Confusion;disability;Education;effectiveness evaluation;Employment;Ethics;Exclusion;experience;Family member;follow-up;Frustration;General Population;Goals;Growth;Health;health care availability;Health Services Research;Healthcare Systems;improved;improved outcome;Independent Living;individuals with autism spectrum disorder;instrument;interest;Intervention;Intervention Studies;Life;Life Cycle Stages;Life Expectancy;Literature;Measures;meetings;Modeling;National Institute of Mental Health;Outcome;Outcome Assessment;Outcome Measure;Participant;patient oriented;Patient Outcomes Assessments;Personal Satisfaction;Policies;Population;Population Heterogeneity;Predictive Factor;Process;programs;Property;Proxy;Psychometrics;Qualitative Methods;Quality of life;recruit;Reporting;Research;Research Personnel;response;Sampling;Series;service intervention;service providers;Services;Social outcome;Social Well-Being;sound;Standardization;Surveys;System;Testing;Time;transition to adulthood;Work

PROJECT_TITLE: Measuring Health, Function, and Social Well-being in Adults on the Autism Spectrum

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Foveal diseases are a major cause of blindness in the United States without current available therapies. In this proposal we propose to recapitulate in vivo patterns of retinoic acid signaling in human stem cell-derived retinal organoids to establish a novel foveated in vitro model system that can be subsequently used as a valuable platform for disease modeling, drug screening and source of fovea-specific cells for transplantation approaches.

PI_NAMEs: DA SILVA, SUSANA ISABEL M M A (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age related macular degeneration;Area;Biological Models;Birds;Blindness;burden of illness;Cell Therapy;Cell Transplantation;Chick;clinically relevant;Cone;Data;density;Development;Disease;disease model;Doxycycline;Drug Screening;effective therapy;Endowment;Enzymes;Experimental Models;Face;fetal;fovea centralis;ganglion cell;Gene Transfer Techniques;Genetic;Goals;High Prevalence;high resolution imaging;high-throughput drug screening;Human;human induced pluripotent stem cells;human stem cell-derived;In Vitro;in vitro Model;in vivo;Individual;innovation;insight;macula;Macular degeneration;Mammals;Microscopy;model organism;Molecular;neural circuit;novel;Organ;Organoids;Pathway interactions;Pattern;pharmacologic;Primates;programs;Property;Protocols documentation;Reading;Regulation;Reporter;Retina;Retinal Diseases;retinogenesis;Rod;Rodent;Role;Signal Transduction;societal costs;Source;spatiotemporal;Speed;Structure;System;Testing;therapy development;tool;Transgenic Organisms;Translating;translational potential;Tretinoin;United States;Vision;Visual Acuity

PROJECT_TITLE: Role of retinoic acid signaling in fovea development

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care

ORG_CITY: Chicago

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Prevention of depressive disorders has become a key priority for the NIMH, but we have no widely available public health strategy to reduce morbidity and mortality. To address this need, we developed and evaluated the primary care based-technology “behavioral vaccine,” Competent Adulthood Transition with Cognitive-Behavioral Humanistic and Interpersonal Therapy (CATCH- IT). We will engage N=4 health systems representative of the United States health care system, and conduct a factorial design study to optimize the intervention in preparation for an implementation study and eventual dissemination.

PI_NAMEs: GLADSTONE, TRACY G;VAN VOORHEES, BENJAMIN W (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: 18 year old;Address;Adolescence;Adolescent;Affect;associated symptom;Behavioral;Cells;Characteristics;China;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive Therapy;collaboratory;Communities;Complex;cost;depression prevention;Depressive disorder;depressive symptoms;design;Developed Countries;Diagnosis;Disease;Dose;Dropout;efficacy trial;experience;Family;follow-up;functional status;Geographic state;Health Status;Health system;Healthcare;Healthcare Systems;high risk;high risk population;High School Student;implementation determinants;implementation study;implementation trial;improved outcome;indicated prevention;interpersonal therapy;Intervention;Mediating;Mediator;Mental Depression;mental disorder prevention;Minor;model design;Modeling;Mood Disorders;Morbidity - disease rate;mortality;multiphase optimization strategy;National Institute of Mental Health;Outcome;parenting intervention;Parents;Participant;peer;PF4 Gene;Phase;Population;population based;Preparation;preservation;prevent;Prevention;Preventive;preventive intervention;Primary Care;primary care practice;protective factors;psychologic;Public Health;Randomized;randomized, clinical trials;Recommendation;recruit;Research Design;resilience;resilience factor;Resources;Risk;rumination;Rural;satisfaction;Selection for Treatments;single episode major depressive disorder;Site;suburb;Symptoms;Technology;technology intervention;Testing;Time;transition to adulthood;Trauma;United States;United States Preventative Services Task Force;Vaccines;Work;Youth

PROJECT_TITLE: Primary Care Based Depression Prevention in Adolescents: Intervention Optimization in Preparation for Implementation Study


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The long-term goal of this proposal is to develop a protein inhibitor against Bcr-Abl, the causative agent of chronic myeloid leukemia (CML) and 30% of acute lymphoblastic leukemia (ALL), that circumvents current problems with Bcr-Abl targeted therapy. Computationally designed coiled- coil proteins will be synthetically made, and will be tested for ability to inhibit dimerization of Bcr- Abl. These peptides are designed to specifically enter leukemia cells, be resistant to degradation, be stable in the bloodstream, and show efficacy in blocking the activity of Bcr-Abl, thus providing a new type of therapy for these leukemias.

PI_NAMEs: LIM, CAROL S. (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Affinity;Amino Acids;Apoptosis;Apoptotic;Area;Bcr-Abl tyrosine kinase;Binding;Biology;Blood Circulation;Bypass;cell killing;Cell Line;Cell Physiology;Cells;Charge;Chemicals;Chromosomal translocation;Chromosome abnormality;Chronic Myeloid Leukemia;chronic myeloid leukemia cell;Clinical;Clinical Trials;clinically relevant;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Computer Models;design;dimer;Dimerization;Disease;drug discovery;Drug resistance;Event;Experimental Leukemia;Genes;Genetic Diseases;Goals;Growth;Heterodimerization;Homo;Homodimerization;Hydrophobicity;improved;in vitro testing;in vivo;Individual;Inflammatory;inhibitor;Intravenous;Lead;Length;leukemia;leukemia treatment;Leukemic Cell;Ligation;Location;Malignant Neoplasms;Mediating;Modeling;mouse model;mutant;mutational status;new technology;novel;novel therapeutic intervention;Oncogenic;Pain;Patients;Penetration;Peptide Synthesis;Peptides;Permeability;Phase;Phosphotransferases;Physiological Processes;pre-clinical;Production;protein oligomer;Protein Tyrosine Kinase;Proteins;Proteolysis;Recurrence;Research Personnel;Resistance;resistance mutation;Sampling;Serum;Shapes;Signal Transduction;Solid;solid state;Specificity;standard of care;stapled peptide;success;targeted agent;targeted treatment;Technology;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic protein;Translations;tumorigenesis;Tyrosine Kinase Inhibitor;Variant;Viral

PROJECT_TITLE: A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_STATE: CA

PHR: Project Narrative Understanding the mechanism behind and treatment of genome abnormalities in the population that cause rare genetic disease in the individual represents a major challenge from both basic science and clinical perspectives. We will study the impact of genetic variation found in the Niemann Pick C1 (NPC1) gene, that, like APOE alleles driving late-onset Alzheimers disease (LOAD), is responsible for management of cholesterol homeostasis. We will use Gaussian process regression machine learning (GPR-ML) based spatial covariance (SCV) tools to define the mechanism of action of proteostasis components found in the Hsp70 axis to therapeutically manage the NPC1 fold leading to improved to cholesterol homeostasis in the individual to provide basic and clinical insight into disease management.

PI_NAMEs: BALCH, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Aging;Alleles;Alzheimer's Disease;Amino Acid Sequence;Automobile Driving;Autophagocytosis;autosome;Basic Science;Biochemical;biochemical tools;Biological Sciences;biophysical tools;Birth;Brain;Buffers;cell type;Cells;Cessation of life;Characteristics;Chemicals;Cholesterol;cholesterol control;Cholesterol Homeostasis;Clinical;Complex;Disease;Disease Management;Disease Progression;disease-causing mutation;druggable target;early onset;Educational process of instructing;Environment;Epigenetic Process;Etiology;fitness;Genes;Genetic;Genetic Diseases;Genetic Variation;Genome;genomic variation;Genotype;Goals;GRP gene;Heat shock proteins;Heat-Shock Response;Human;human disease;human model;improved;Individual;Inherited;insight;Knowledge;late endosome;Late Onset Alzheimer Disease;Learning;Lipids;loss of function;Lysosomes;Machine Learning;Modernization;Molecular;Molecular Chaperones;Molecular Mechanisms of Action;multicatalytic endopeptidase complex;Nervous System Disorder;Neurodegenerative Disorders;Niemann-Pick Diseases;novel;Pathology;Pathway interactions;Patients;Phenotype;polypeptide;Population;precision medicine;prevent;Process;prognostic;protein folding;protein function;protein misfolding;Proteins;proteostasis;Rare Diseases;rare genetic disorder;rare variant;Resolution;response;Role;Signal Pathway;small molecule;Specificity;Stress;Structure;System;Target Populations;Therapeutic;Therapeutic Intervention;Time;tool;trafficking;Ubiquitin;Uncertainty;Variant

PROJECT_TITLE: Using Genetic Diversity to Manage Neurological Disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Chronic pain disproportionately affects Veterans and is often managed in VA primary care. Because chronic pain may exhibit physical, emotional, social, and existential dimensions, it is also a condition for which interdisciplinary team approaches are clinically important. A variety of pain team models have been implemented in diverse clinical settings and many have been found to be effective. Highly functioning interdisciplinary teams, however, are difficult to actualize, especially when teams have dynamic membership and different providers slot onto teams to fulfill specific roles or tasks around a specific patient’s pain management plan. I therefore propose to develop an intervention to improve the act of dynamic teaming around the multiple shared tasks involved in managing chronic pain. This research brings the theory, methods, and lessons learned from the organizational behavior literature to the challenge of chronic pain management. This proposal offers a timely response to VA HSR&D’s priority of addressing pain and opioid use, both of which are occurring in epidemic proportion.

PI_NAMEs: GIANNITRAPANI, KARLEEN FRANCES (contact)

PROJECT_TERMS: academic preparation;acceptability and feasibility;Address;Affect;arm;Award;base;Behavior;Binding;career;career networking;Caring;chronic pain;chronic pain management;Clinical;clinical care;Cluster randomized trial;Collaborations;Complex;design;Dimensions;Discipline;Education;Elements;Emotional;Empirical Research;Ensure;Epidemic;Evaluation;Exhibits;experience;Future;Goals;Homogeneously Staining Region;implementation science;improved;innovation;insight;interdisciplinary approach;Intervention;intervention mapping;Interview;Leadership;Learning;Literature;Logic;Mediation;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;novel;novel strategies;Opioid;opioid tapering;opioid use;Pain;Pain management;Patient Care;Patients;Perception;Pharmacists;pilot test;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Primary Care;primary care patient;primary care setting;primary care team;Process;process improvement;Production;programs;Provider;Randomized;randomized controlled design;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Reaction Time;recruit;Research;Resources;Role;scaffold;Scientist;Site;skills;social;Specialist;Structure;systematic review;Team Process;Techniques;Testing;theories;therapy design;therapy development;Thinking;Training;treatment arm;treatment as usual;trial design;Twin Multiple Birth;user centered design;Veterans;Work

PROJECT_TITLE: Building Better Interdisciplinary Pain Teams Across Disciplines


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Steady-state hematopoiesis in bone marrow is critical for maintenance of blood cell genesis and immune competence throughout life. Concomitant with aging, the bone marrow hematopoietic stem cell (HSC) compartment produces fewer lymphoid lineage progeny and the molecular basis remains unknown. The goal of this project is to determine the role of the HOX protein Hoxa9 in regulation of lymphopoietic potential from HSC.

PI_NAMEs: MEDINA, KAY LYNN (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Age;age related changes;aged;Aging;Attention;B-Lymphocytes;Blood Cells;Bone Marrow;CDKN2A gene;Cell Compartmentation;Cell Lineage;Cells;Cellularity;Common Lymphoid Progenitor;Cyclin-Dependent Kinase Inhibitor;cytokine;Data;Defect;Development;Elderly;Exhibits;experimental study;Frequencies;Genes;genomic locus;Germ Lines;Goals;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Homeobox;HOXA9 protein;humoral immunity deficiency;immune function;Immune System Diseases;Immunocompetence;Impairment;In Vitro;Infection;Knockout Mice;Knowledge;Life;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphopoiesis;Maintenance;Marrow;Messenger RNA;Modeling;Molecular;Mus;Myelogenous;Myeloid Progenitor Cells;novel;novel therapeutics;Output;overexpression;p19ARF;progenitor;Proliferating;promoter;Publications;Radiation Chimera;Regulation;Rejuvenation;response;Role;senescence;SLAM protein;stem cell biology;stem cells;T-Lymphocyte;Thymus Gland;Time;Transcript;transcription factor;Transplantation;Tumor Suppressor Genes;tumorigenesis;vaccine response;virtual;young adult

PROJECT_TITLE: Regulation of the lymphoid cell fate by Hoxa9

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The focus of the proposed study contributes to National Institute on Aging’s goals of promoting research that utilizes multilevel approaches to elucidate mechanisms that contribute to health disparities in Alzheimer’s disease and related disorders (ADRD), and to identify malleable targets for interventions to ameliorate health disparities. Guided by the NIH-Stage Model, this study will complete the initial stage of the model to identify the mechanisms which ADS influence caregiving-related stressors and needs for African American dementia caregivers. Findings from the study will be used to inform the development of a culturally-tailored stress reduction intervention for African American dementia caregivers.

PI_NAMEs: PARKER, LAUREN  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adult;African American;African American population;Age;age acceleration;age-related disease;alpha-amylase;Alzheimer's disease related dementia;American;Award;Biological Markers;Biological Products;biopsychosocial;caregiver stress;Caregiver well-being;Caregivers;caregiving;Caring;Collection;Communities;Coping Behavior;Coping Skills;culturally appropriate intervention;dehydroepiandrosterone;Dehydroepiandrosterone Sulfate;Dementia;Dementia caregivers;dementia caregiving;depressive symptoms;design;Development;diaries;expectation;experience;Family Caregiver;Family member;Goals;Health;health disparity;Home;Hour;Hydrocortisone;implementation science;improved;Individual;Intervention;Interview;Length;Measures;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;multilevel analysis;National Institute on Aging;Outcome;Pattern;perceived stress;Persons;Physiological;psychosocial;Psychosocial Assessment and Care;Psychosocial Stress;Reporting;Research;Research Personnel;Resources;respite care;response;Salivary;Sampling;Security;service programs;service utilization;Services;Site;social stigma;Social support;Source;Stress;stress management;stress reduction;Stressful Event;stressor;Structure;Survey Methodology;telomere;Telomere Shortening;therapy development;Time;Training;Training Programs;Transportation;United States National Institutes of Health

PROJECT_TITLE: Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative During cell division, duplicated chromosomes are organized and separated by an exquisite molecular machine, the mitotic spindle. This project will bring us closer to a complete understanding of how the spindle works. Understanding the mitotic spindle is critical for developing better chemotherapeutics. Drugs that target tubulin are used against many cancers, but they cause considerable side effects. Unlike tubulin, however, other spindle components function only in dividing cells, so new drugs targeting these components could stop cancer proliferation with fewer side effects. In addition to its medical relevance, the work will bring us closer to a complete understanding of one of nature’s most fascinating molecular machines.

PI_NAMEs: ASBURY, CHARLES  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Affect;Anaphase;Architecture;Area;Behavior;Binding;Biological Assay;biophysical analysis;biophysical tools;Cell Cycle;Cell division;Cells;Centromere;Centrosome;chromosome movement;Chromosome Segregation;Chromosome Structures;Complex;Coupling;DNA;Drug Targeting;experience;fascinate;Feedback;Fluorescence;Goals;grasp;in vivo;Individual;Kinetochores;Lasers;Malignant Neoplasms;Measurement;Measures;Mechanics;Medical;Microtubules;Mitosis;Mitotic spindle;Molecular Machines;Monitor;Motility;Movement;Nature;new therapeutic target;particle;Proliferating;Recombinants;reconstitution;self assembly;side effect;Signal Transduction;single molecule;spindle pole body;Techniques;Testing;Therapeutic;transmission process;Tubulin;Weight-Bearing state;Work;Yeasts

PROJECT_TITLE: Reconstitution and biophysical study of chromosome segregation machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sepsis

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cognitive and functional decline are common and devastating consequences of sepsis survivorship. Alzheimer’s disease neuropathology is common in the cognitively normal population and may represent a latent risk factor for persistent brain dysfunction in sepsis survivors. We hypothesize that amyloid beta neuropathology and sepsis enhance activity of the complement system in the brain, driving neuroinflammation, glial activation, and synapse loss.

PI_NAMEs: SINGER, BENJAMIN HERSCHEL (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta deposition;Acute;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid beta-Protein;amyloid pathology;Amyloidosis;Animal Model;Automobile Driving;Bacteremia;Behavioral;behavioral impairment;Biological Markers;Brain;brain dysfunction;Brain Injuries;brain tissue;C3AR1 gene;Cell Culture Techniques;Chemosensitization;Chronic;Cognition Disorders;Cognitive;Collection;comorbidity;Complement;Complement 3a;Complement Activation;Complement Receptor;complement system;cost;Critical Care;Critical Illness;cytokine;Dependence;Discrimination;functional decline;Functional disorder;Functional impairment;Future;glial activation;Hippocampus;Human;Impaired cognition;Impairment;improved;Individual;Infection;Injury;injury prevention;Ligands;Measures;Mediating;Microfluidics;Microglia;Modeling;Mood Disorders;Motivation;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neuroglia;neuroinflammation;neuropathology;neuroprotection;novel;Nuclear;Outcome;Pathology;Patients;Peritoneal;personalized strategies;Phagocytosis;Phenotype;Population;Problem Solving;receptor;Receptor Inhibition;Risk;Risk Factors;Role;senescence;Sepsis;Signal Transduction;spatial memory;Survivors;survivorship;Synapses;Synaptic Transmission;Synaptosomes;Syndrome;systemic inflammatory response;transcriptome;United States

PROJECT_TITLE: Enhancement of Brain Dysfunction in Sepsis Survivors by Alzheimer’s Disease Neuropathology

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Narrative A broadly neutralizing antibody (bnAb)-directed HIV vaccine is possible in concept, but exceptional immunological hurdles must be overcome to reach that goal. Major limitations in our understanding of the biology of GCs to difficult antigens include (1) “Is immunodominance in GC responses preventing development of bnAbs to conventional immunizations?”, and 2) “Is sustained exposure to antigen in GCs necessary for the extensive somatic hypermutation (SHM) associated with the generation of bnAbs?” We will explore these questions in the context of a candidate HIV vaccine.

PI_NAMEs: CROTTY, SHANE P (contact);IRVINE, DARRELL J

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Affinity;aluminum sulfate;Animal Model;Animals;Antigens;Autologous;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biology;Blood;Bolus Infusion;CD4 Positive T Lymphocytes;Cells;design;Development;draining lymph node;Epitopes;Experimental Designs;experimental study;Exposure to;Fine needle aspiration biopsy;Funding;Generations;Goals;Haptens;Helper-Inducer T-Lymphocyte;HIV;HIV vaccine;Human;Immune response;Immunity;Immunization;Immunize;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;improved;in vivo;innovation;Joints;Knowledge;lymph nodes;Macaca mulatta;Maps;Memory;Methods;Modeling;Mutation;neutralizing antibody;new technology;nonhuman primate;novel;novel strategies;Osmosis;pathogen;prevent;Primates;Proliferating;Pump;Reaction;Regimen;Research;Resolution;response;Running;Secondary Immunization;single cell sequencing;Spleen;Structure of germinal center of lymph node;System;Technology;Testing;Time;trait;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine delivery;vaccine immunogenicity;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: Maximizing germinal centers and somatic hypermutation to HIV Env immunogens

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative  Low-level chronic inflammation (LLCI) occurs in mammals during aging as a result of responses in the immune system to a variety of stimuli and contributes to bone loss and the development of osteoporosis, but the mechanisms by which LLCI induces age-related bone loss remain incompletely understood. We have identified a new subset of white blood cells (B lymphocytes, which we have called RANKL+CXCR4+ B lymphocytes, RCBs for short), that accumulate in the bone marrow during aging where they appear to stimulate bone destruction and inhibit new bone formation. We plan to further investigate the biological functions of RCBs, the mechanisms that induce their accumulation in the bone marrow during aging, and to test the effects of compounds that might specifically reduce RCB accumulation in the bone marrow in animal models of age-related osteoporosis and be developed into new drugs.

PI_NAMEs: BOYCE, BRENDAN F (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adverse effects;age related;Age-Related Bone Loss;Age-Related Osteoporosis;Aging;aging related disease;Alendronate;AMD3100;Anatomy;Animal Model;antagonist;B-Lymphocyte Subsets;B-Lymphocytes;Biological Process;BIRC4 gene;bisphosphonate;bone;Bone Formation Inhibition;bone loss;Bone Marrow;bone mass;Bone Resorption;Bone Resorption Stimulation;CD19 gene;Cells;chemokine;Chronic;conditional knockout;CXCR4 gene;Data;Development;differentiation in vitro;Dose;early onset;Elderly;FDA approved;Formulation;Forteo;Genetic Transcription;Heterogeneity;Human;Immune system;Immunoglobulin D;Immunoglobulin M;Individual;Inflammation;Inflammatory;inhibitor;Leukocytes;life span;Ligands;Location;Mammals;Mediating;Memory B-Lymphocyte;mesenchymal stromal cell;microCT;Molecular;Mus;novel;novel therapeutics;old mice;osteoblast differentiation;Osteoclasts;Osteogenesis;Osteoporosis;Pathogenesis;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;prevent;Prevention;Production;protein function;Proteins;PTPRC gene;Publishing;receptor;Reporting;response;Rheumatoid Arthritis;Route;scale up;Signal Transduction;Spleen;Stimulus;Stromal Cell-Derived Factor 1;substantia spongiosa;Surface;Testing;TNF receptor-associated factor 3;TNFSF11 gene;Transforming Growth Factor beta;ubiquitin-protein ligase;Vertebral Bone

PROJECT_TITLE: Studies of the fate of the osteoclast

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Immunotherapy;Inflammatory Bowel Disease

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of the underlying mechanisms leading to the development of senescent FOXP3+ cells in inflammation will open novel experimental therapeutics, including cellular therapy in human Inflammatory Bowel Disease (IBD) and other immune- mediated diseases (i.e., rheumatologic, neurologic, dermatologic conditions, and cancer). Insight into the development of senescent FOXP3+ cells will benefit TREG cell therapy trials, as well as trials of epigenetic regulators in cancer research. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge to reduce human illness.

PI_NAMEs: GONZALEZ SALGADO, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adoptive Cell Transfers;Aging;anti-cancer research;Antibodies;Articulation;Autoimmune Diseases;Automobile Driving;Biochemistry;Biological Assay;BMI1 gene;CD4 Positive T Lymphocytes;Cell Aging;Cell Therapy;Cells;cellular engineering;Coculture Techniques;Complex;Crohn's disease;Data;Data Set;Dermatologic;Development;Developmental Cell Biology;differential expression;Disease;Drug Targeting;Engineering;epigenetic drug;Epigenetic Process;ETS1 gene;Event;FOXP3 gene;gene network;gene repression;Gene set enrichment analysis;Genes;genetic signature;Genetic Transcription;Goals;gut inflammation;Hand;Human;Human Engineering;Immune;In Vitro;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;innovation;insight;Investigational Therapies;Knowledge;Laboratories;Lamina Propria;Lesion;Lymphocyte;Malignant Neoplasms;Mediating;member;Mission;Mucositis;Neurologic;new therapeutic target;novel;Outcome;Pathogenicity;Patients;Phenotype;Polycomb;PRC1 Protein;programs;Public Health;Reagent;Regulatory T-Lymphocyte;Repression;Research;senescence;senescence associated secretory phenotype;senescent cell;Signal Transduction;System;T cell therapy;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Therapy trial;TNF gene;transcription factor;Transcriptional Activation;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Aging lymphocytes: senescence programs in lymphocytes relevant to human inflammatory bowel disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Data Science;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Inflammatory bowel disease (IBD) affects over 1.3 million Americans, but despite intensive research, the exact cause of IBD remains unclear. Interactions between the surface proteins and sugars of microbes and human cells have important effects on inflammation and its regulation, but their investigation is difficult due to the complex genetic and chemical environment of the gut. This project aims to design and apply advanced computational methods based on deep learning to enhance the discovery of significant changes in microbial proteins and sugars with a goal of gaining new insights into the development, progression, and treatment of IBD.

PI_NAMEs: TAN, XIAO  (contact)

PROJECT_TERMS: Affect;Algorithms;American;anti-microbial peptide;Automated Annotation;Bacterial Proteins;Binding;Biochemical;Biological;Biological Process;Biomedical Research;Carbohydrates;career development;Catalogs;Cell surface;Cells;Characteristics;Chemicals;Chronic;Chronic Disease;Classification;Collection;Complex;complex data;computational pipelines;Computing Methodologies;Data;Databases;deep learning;deep learning algorithm;deep neural network;density;design;Development;dietary;Digestive System Disorders;Disease;DNA;Environment;Environmental Exposure;Environmental Risk Factor;Enzymes;Evaluation;Event;experimental study;Gastroenterology;gene product;General Hospitals;Genes;Genetic;Glycobiology;Goals;gut microbes;gut microbiome;gut microbiota;Health Expenditures;high dimensionality;host-microbe interactions;Human;Human Genetics;Immune;Immune response;Immunity;immunogenicity;Immunologics;improved;in vitro Assay;in vivo;Inflammation;Inflammatory Bowel Diseases;Information Retrieval;insight;instructor;Intestines;Investigation;Label;large datasets;Life;Machine Learning;machine learning algorithm;machine learning method;Massachusetts;Mediating;medical schools;Medicine;Membrane;Membrane Proteins;Mentors;metabolomics;metagenome;Metagenomics;Methods;Microbe;microbial;microbiome analysis;Modification;Morbidity - disease rate;multidimensional data;murine colitis;Natural Language Processing;novel;Nucleic Acids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;Performance;Physicians;Polymers;Polysaccharides;Process;Program Development;protein function;Protein Secretion;Proteins;Proteome;Proteomics;Regulation;Research;Scientist;Semantics;Series;skills;Source;Speech;stool sample;Structure;sugar;Surface;Taxonomy;Techniques;Testing;Text;tool;Training;Translations;United States;Validation;validation studies;vector;Writing

PROJECT_TITLE: Machine learning-based methods for the analysis of microbial glycomes and proteomes in inflammatory bowel disease.


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Small RNA drugs hold great promise for the study and treatment of neurodegenerative disorders, but they must be chemically modified for efficient delivery to the central nervous system (CNS). This project will determine how chemical modifications impact small RNA activity and localization in the CNS, and will use this information to design optimized small RNA drugs to dissect the role of nuclear Huntingtin RNA toxicity in Huntington’s Disease (HD). Findings from this study will inform optimal treatment strategies for HD, and build a framework for therapeutic small RNA design for use in the CNS.

PI_NAMEs: HILDEBRAND, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;Affect;Architecture;Bar Codes;Behavioral;Bilateral;Binding;Biochemical;Biology;Brain;Brain region;CAG repeat;Cell Nucleus;Central Nervous System;Central Nervous System Diseases;Chemicals;Chemistry;Corpus striatum structure;Cytoplasm;Data;design;Development;Disease;Disease Progression;Ensure;Exons;flexibility;Fluorescence Microscopy;Functional disorder;gait examination;Gene Silencing;Genes;High-Throughput Nucleotide Sequencing;Huntington Disease;Huntington gene;In Vitro;in vivo;Injections;insight;Kinetics;Length;Libraries;Measures;Mediating;Messenger RNA;Methods;Microscopy;Modification;Molecular Conformation;motor deficit;mRNA Expression;Mus;mutant;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;nonhuman primate;novel therapeutics;Nuclear;Nuclear RNA;Nucleotides;optimal treatments;Pathogenicity;Pathology;Pattern;Pharmaceutical Preparations;Physiological;polyglutamine;Positioning Attribute;Preparation;Production;progressive neurodegeneration;Proteins;Research;Ribose;RNA;RNA Biochemistry;RNA Interference;RNA Splicing;RNA-Induced Silencing Complex;Rodent;Role;single molecule;Small Interfering RNA;Small RNA;Testing;Therapeutic;Therapeutic Intervention;therapeutic RNA;therapeutic siRNA;Time;tool;Toxic effect;transcriptome sequencing;treatment strategy;Trinucleotide Repeat Expansion;uptake;Work

PROJECT_TITLE: The Impact of Nucleotide Modification Patterns on Therapeutic Small Interfering RNA Activity in the Central Nervous System


PHR: Veterans are more likely than the general population to experience chronic pain. Opioid medications are sometimes used to treat chronic pain, but other treatment strategies, including opioid tapering or switching to buprenorphine, might be good alternatives to traditional opioid therapy, especially for patients experiencing opioid misuse. The results of this project will make it easier to identify when patients taking opioids for chronic pain are at high risk for adverse outcomes, and determine which treatments are most effective at both reducing risks and managing pain. Veterans and Veterans Health Administration providers will be consulted about translating results into practice to improve care for Veterans with chronic pain.

PI_NAMEs: BOHNERT, AMY S B;LAGISETTY, POOJA  (contact)

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;Algorithms;American;Analgesics;Area;Buprenorphine;Caring;Centers for Disease Control and Prevention (U.S.);chronic pain;chronic pain management;chronic pain patient;Classification;Clinical;clinical practice;clinical research site;cohort;comparative effectiveness;comparative efficacy;compare effectiveness;Computerized Medical Record;Consumption;cost;Country;Data;data warehouse;Diagnosis;Diagnostic;diagnostic criteria;Documentation;Dose;effective therapy;Effectiveness;Elasticity;Enrollment;evidence base;Evidence based treatment;Exclusion;Exhibits;experience;falls;Feedback;Fright;Funding;Future;General Population;Goals;Guidelines;Harm Reduction;Health;Health Services Accessibility;Health Services Research;high risk;improved;Individual;innovation;International Classification of Disease Codes;Intervention;Interview;Knowledge;large datasets;medication for opioid use disorder;Mental Health;Methodology;Methods;novel;Opioid;opioid misuse;Opioid Rotation;opioid tapering;opioid therapy;opioid use disorder;Outcome;Overdose;Pain;Pain intensity;Pain management;patient oriented;patient population;patient safety;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacy facility;Population;prescription opioid;prescription opioid misuse;Process;Provider;Qualitative Methods;randomized, clinical trials;recruit;Research;research and development;Research Design;Risk;Risk Behaviors;Safety;safety outcomes;Sampling;Screening procedure;secondary analysis;Selection Bias;Signs and Symptoms;Site;Speed;Structure;structured data;study population;symptomatic improvement;Symptoms;Testing;tool;Translating;treatment strategy;trial readiness;Veterans;Veterans Health Administration;Withdrawal;Work

PROJECT_TITLE: Diagnosing and Treating Veterans with Chronic Pain and Opioid Misuse

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE We will collaborate with the Black Ministerial Alliance TenPoint (BMATP) of Greater Boston to develop a smartphone-based Embodied Conversational Agent app that provides education about SARS-CoV-2 and influenza vaccination, and motivates vaccination completion, following public health guidelines. We will evaluate the intervention in a clinical trial involving 600 congregants from 12 predominately African American churches.

PI_NAMEs: BICKMORE, TIMOTHY W. (contact);PAASCHE-ORLOW, MICHAEL ;PARKER, ANDREA G

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 2019-nCoV;Address;Adult;African American population;American;Attitude;automated intervention;Behavior;behavior change;Behavior Therapy;Belief;Black church;Black race;Boston;Cellular Phone;chatbot;Church;Clinical Trials;Collaborations;Collection;Communication Methods;Communities;community based participatory research;community based research;Computers;Counseling;COVID-19;COVID-19 burden;COVID-19 vaccination;COVID-19 vaccine;Cues;design;dietary adherence;Disparity;distrust;Education;Effectiveness;Epidemic;ethnic disparity;Evaluation;Family health status;Focus Groups;gaze;Gender;Gestures;good diet;Guidelines;Hand;Health;Health behavior;health literacy;health organization;Health Promotion;Healthcare;high risk;Hispanic;Hospitalization;improved;Individual;infection rate;Influenza vaccination;influenza virus vaccine;Instruction;intersectionality;Intervention;Knowledge;Language;low health literacy;Low Literacy Population;Measurement;Mediator;Medical center;medication compliance;member;Methods;Misinformation;mortality;Nature;non-verbal;Notification;Ontology;Outcome;Participant;Physical activity;Population Intervention;Public Health;Race;racial disparity;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;Religion;Religiosity;Respondent;Safety;Series;Source;Spirituality;stress management;System;Testing;Theoretical model;therapy design;Time;Trust;Universities;Vaccinated;Vaccination;vaccine effectiveness;vaccine hesitancy;vaccine trial;Vaccines;Voice;Work;Writing

PROJECT_TITLE: Community-based Design and Evaluation of a Conversational Agent to Promote SARS-COV2 Vaccination in Black Churches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-G(90)S]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: This proposal addresses the need for better understanding of the neurobehavioral basis of the compulsive and chronically relapsing nature of alcohol addiction. Neurobiological and medications development information from animal models of relapse to alcohol use is limited largely to studies in alcohol nondependent animals. To advance understanding of the alcohol addiction process and ultimately improve treatment strategies, the proposed studies will investigate the significance of a previously not well recognized but presumably major factor in relapse vulnerability: the effects of stimuli conditioned to the potent addictive dimensions of alcohol associated with alcohol consumption to ameliorate withdrawal distress and neurobiological basis of these stimulus effects.

PI_NAMEs: WEISS, FRIEDBERT  (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: abuse liability;addiction;Addictive Behavior;Address;alcohol availability;Alcohol consumption;alcohol craving;Alcohol dependence;alcohol effect;alcohol reinforcement;alcohol relapse;alcohol seeking behavior;Alcohols;Animal Model;Animals;Behavior;Behavior Control;Behavioral;Brain region;Chronic;conditioning;craving;Cues;Darkness;Data;Dedications;Dependence;design;Development;Dimensions;Distress;drinking;Ethanol;Ethanol dependence;experience;Foundations;Future;improved;Individual;insight;Learning;Link;Location;Measures;Mediating;Modeling;Motivation;Nature;Negative Reinforcements;neural;Neuroanatomy;neurobehavioral;Neurobiology;neurochemistry;Neurons;novel;Pharmaceutical Preparations;Pharmacogenetics;Phenotype;Play;problem drinker;Process;Psychological reinforcement;Punishment;Rattus;Recording of previous events;recruit;Relapse;research and development;Resistance;Role;Severities;Side;Stimulus;treatment strategy;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: The dark side of addiction: Significance of environmental conditioning to negative reinforcement by EtOH in subjects with a dependence history


PHR: Project Narrative - Center for Viral Systems Biology (CViSB) Lassa virus, Ebola virus, and SARS-CoV-2 are three of the most devastating human pathogens, yet some individuals are better able to ﬁght infection than others. We will perform system-wide analyses of host, virus, and environmental factors that contribute to the severity and spread of human disease. By creating large integrated systems data sets of clinical, genetic, immunological, biological, microbial, functional, and physiological features, we will build sophisticated predictive models that will reveal the molecular interactions and network structures underlying successful clearance of Lassa, Ebola, and SARS-CoV-2 viruses.

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immunity;Africa;application programming interface;Area;Binding;Bioinformatics;Biological;biosignature;candidate identification;Cessation of life;Clinical;cohort;Communicable Diseases;Communities;Complex;Computer software;COVID-19;COVID-19 pandemic;Data;data management;Data Set;Databases;Disease;Disease Outbreaks;Disease Outcome;Ebola;Ebola virus;Education and Outreach;Educational workshop;Environment;Environmental Risk Factor;Evolution;experimental study;FAIR principles;fighting;fundamental research;Generations;Genetic;genomic data;Goals;Growth;Human;human disease;human pathogen;Immunity;Immunologics;Immunology;Individual;Infection;insight;Intervention;large scale data;Lassa;Lassa virus;long-term sequelae;Machine Learning;Maps;Metabolic;Methods;microbial;Modeling;Molecular;Molecular Epidemiology;open source;Outcome;Paper;pathogen;Pathway Analysis;Patients;Physiological;Play;Population;predictive marker;predictive modeling;priority pathogen;response;Risk;Scientist;Severities;Severity of illness;Structure;Survivors;System;Systems Biology;Technology;Time;tool;translational applications;translational approach;United States;Vaccinee;Vaccines;Variant;Viral;viral genomics;Virus;Visualization;wearable device;web platform;Work


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: Africa;Bioinformatics;Budgets;Clinical;cohort;Collaborations;Communicable Diseases;Communication;Communities;Coordination and Collaboration;cost effective;COVID-19 pandemic;data management;data sharing;data sharing networks;Educational workshop;Ensure;Funding;General Population;Goals;Infectious Diseases Research;Leadership;Manuscripts;meetings;member;Modeling;Monitor;National Institute of Allergy and Infectious Disease;open source;operation;organizational structure;outreach;Postdoctoral Fellow;Preparation;programs;Progress Reports;Research;Research Project Grants;Research Support;Resources;Schedule;Scientist;Site;Structure;Students;symposium;Systems Biology;Technology;timeline;Travel;Viral

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HUGHES, LAURA D. (contact)

PROJECT_TERMS: Adoption;Bioinformatics;bioinformatics pipeline;bioinformatics tool;biological systems;Communicable Diseases;Communities;community engagement;Complex;Computer software;computerized tools;Consumption;contextual factors;COVID-19;Data;data exploration;data management;data platform;data portal;data reuse;Data Set;data sharing;data tools;design;Dimensions;Disparate;Ebola;Ecosystem;Education and Outreach;FAIR principles;Generations;Genetic;Genomics;Glues;Goals;heterogenous data;Immunologics;improved;Infrastructure;innovation;interdisciplinary approach;Knowledge;Lassa;microbial;Mission;Modeling;Molecular;Monitor;multidimensional data;multidisciplinary;novel;open data;Outcome;outreach;pathogen;Physiological;predictive modeling;Proliferating;Publishing;Research;Research Personnel;Software Tools;Systems Biology;Testing;Time;tool;Training;Viral;Virus;Visualization;Visualization software;web platform

PROJECT_TITLE: Data Management and Bioinformatics Core


ORG_NAME: ALLEN INSTITUTE

PHR: Narrative, Overall (Thalamus in the middle: computations in multi-regional neural circuits) The thalamus is the main conduit for subcortical information flow to the cortex. Despite decades of work in the sensory thalamus, we know little about non-sensory (or 'higher-order') thalamus, even though higher-order thalamus is the largest part of the thalamus and damaging it can cause cognitive and motor disorders, as well as coma and hypersomnia. This collaboration will map the architecture of subcortex → thalamus → cortex circuits, measure functional relationships of these brain regions with cell type-specificity during multiple cognitive behaviors, and synthesize these data in conceptual and computational models for a multi-regional neural circuit theory of cognition.

PI_NAMEs: CARTER, ADAM G;CHANDRASHEKAR, JAYARAM ;JARAMILLO, JORGE H;SVOBODA, KAREL  (contact);TASIC, BOSILJKA

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Amygdaloid structure;Anatomy;Anterior;Architecture;Area;artificial neural network;Basal Ganglia;Behavior;Brain;Brain region;cell type;Cells;Censuses;Cerebellum;cloud based;Cognition;Cognition Disorders;Cognitive;cognitive function;Collaborations;Coma;Communication;Communities;Complex;Computer Models;Coupled;Data;Data Analyses;Data Science Core;data sharing;Decision Making;dynamic system;Electrophysiology (science);Enhancers;epigenetic profiling;Evolution;experimental study;flexibility;frontal lobe;Future;Genetic;Hippocampus;Human;Hypersomnias;Image;In Vitro;in vivo;Individual;invention;Knowledge;Lateral;Learning;Link;Logic;long short term memory;Machine Learning;Maintenance;Maps;Measurement;Measures;Medial;Memory;Methods;Midbrain structure;Modeling;Modernization;Molecular;Morphology;Motor;Motor Cortex;motor disorder;Movement;Mus;Neocortex;neocortical;neural;neural circuit;neural model;neural network;neural patterning;Neurons;neurophysiology;Neurosciences;novel;optogenetics;Output;Physiology;Prefrontal Cortex;Property;Prosencephalon;Reagent;Resources;response;Route;Science;Sensory;sensory system;Shapes;Short-Term Memory;Signal Transduction;single-cell RNA sequencing;Slice;Specificity;Structure;Synapses;Testing;Thalamic Nuclei;Thalamic structure;theories;tool;transcriptomics;Transgenic Organisms;Update;virtual;Virus;voltage;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: BRINEY, BRYAN  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;advanced system;Affect;Antibodies;Area;Binding;Bioinformatics;biological systems;Cells;Classification;Clinical;Collaborations;Complex;Computer Models;Computing Methodologies;cost;cost effective;COVID-19;Data;data management;Data Set;data standards;Ebola;Emerging Technologies;Ensure;experience;experimental study;Generations;genomic data;Goals;Government;Heart;Hospitals;Hybrids;immune function;improved;innovation;Investments;Lassa;Lassa virus;Methods;Mission;Modeling;multidisciplinary;multiple omics;next generation;novel;Outcome;Positioning Attribute;predictive modeling;Procedures;Protocols documentation;Research Personnel;Role;Sampling;Services;Sierra Leone;Specificity;Standardization;Systems Biology;Techniques;Technology;tool;Training;Translating;Viral;Viral Genome;Virus;ZIKA

PROJECT_TITLE: Technology Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Narrative, Administrative Core The Administrative Core will provide the leadership and organizational structure to align the efforts of the individual Institutions, projects and researchers to meet the overall goals and milestones. This will involve integrating and aligning the efforts of five Research Projects (detailed map of region-specific and cell type- specific connectivity between subcortex, thalamus, and cortex; connectivity based on electrophysiology and optogenetics; high-density electrophysiology in multi-regional circuits; and multi-regional network models of computation and behavior), the Molecular Science Core (thalamocortical molecular tools), and the Data Science Core. The Administrative Core will oversee the operational management including strategic planning, project management, progress reporting, fiscal management, manuscript and authorship planning, conflict resolution and support for collaboration and communication to create, integrate, and disseminate to the community high- value anatomical and neurophysiological data as well as cloud-based data analysis workflows.

PI_NAMEs: SVOBODA, KAREL  (contact)

PROJECT_TERMS: Achievement;Adherence;Adopted;Adoption;Anatomy;Architecture;Area;Authorship;Behavior;Behavioral;Budgets;cell type;cloud based;Collaborations;Communication;Communities;computational network modeling;Computer software;computerized data processing;conflict resolution;Data;Data Analyses;data exchange;data integration;data quality;data resource;Data Science Core;data sharing;data standards;density;design;Electrophysiology (science);Ensure;experience;Feedback;Fostering;frontal lobe;Generations;Goals;Image;Individual;Industry;Infrastructure;Institution;Joints;Leadership;Life Cycle Stages;Logic;Manuscripts;Maps;member;Modernization;Molecular;Monitor;multimodal data;neural;neural circuit;neurophysiology;Neurosciences;New York;optogenetics;organizational structure;Performance;Phase;Procedures;Process;Production;programs;Progress Reports;Publications;Quality Control;Reporting;repository;Research;Research Personnel;Research Project Grants;Resources;Risk Management;Role;Route;Science;Shapes;Signal Transduction;Site;software development;Software Tools;Standardization;Strategic Planning;Structure;Synapses;synergism;Thalamic structure;theories;Time;tool;Universities


NIH_SPENDING_CATS: Bioengineering;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PHR: Narrative, Data Science Core The Data Science Core will implement reproducible and documented ingestion and analysis workflows for complex neuroanatomical, neurophysiological and behavioral data, using best practices, including FAIR (Findable, Accurate, Interoperable, Reusable) data principles. These cloud-based workflows will facilitate data sharing within the collaboration and sharing of 'data products' with the scientific community at large.

PROJECT_TERMS: Adult;Algorithmic Analysis;Algorithms;analysis pipeline;Anatomy;Architecture;Atlases;Behavior;Behavioral;Brain;Cell Nucleus;cell type;cloud based;Collaborations;Collection;Communities;complement resource;Complex;complex data;computational pipelines;computer infrastructure;Computer software;Data;Data Analyses;data format;data infrastructure;data modalities;data pipeline;data repository;Data Science;Data Science Core;Data Set;data sharing;data standards;Databases;design;Development;Dimensions;Ecosystem;Electrodes;Electrophysiology (science);extracellular;flexibility;Fluorescent in Situ Hybridization;Geography;Image;Immunohistochemistry;improved;in vivo;Individual;Infrastructure;Ingestion;interoperability;Knowledge;large scale data;large scale simulation;Link;Location;Logic;Maps;Measurement;Metadata;metadata standards;meter;Modeling;Modernization;Molecular;multimodality;neural circuit;Neuroanatomy;neurophysiology;open data;open source;optogenetics;Paper;parallelization;Physiology;Process;Quality Control;Reagent;Recording of previous events;repository;Reproducibility;Research;Research Project Grants;Resolution;Science;single molecule;Site;Slice;Software Engineering;Standardization;Stimulus;Synapses;System;Thalamic structure;tool;transcriptomics;voltage;web interface

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In keeping with NIA’s mission of supporting behavioral and social age-related research – with an emphasis on studying Alzheimer’s disease and other Dementias – as well as the strategic direction to better understand and address the social impacts and burden of age-related disease, this proposal tests an intervention to reduce depression and anxiety among family caregivers of persons living with dementia (PLWD) as well as reduce grief intensity among family caregivers PLWD. In the Caregiver Speaks intervention, caregivers will engage in photo-elicitation storytelling (sharing photos that capture their thoughts, feelings, and reactions to caregiving and bereavement) via a privately facilitated Facebook group. This intervention will longitudinally follow caregivers from active caregiving and into bereavement.

PI_NAMEs: PARKER OLIVER, DEBRA  (contact);ROLBIECKI, ABIGAIL J

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;age related;age-related disease;Alzheimer's Disease;American;Anxiety;arm;base;Behavior Therapy;Behavioral;Bereavement;Bereavement Care;care burden;caregiver depression;Caregivers;caregiving;Caring;Cessation of life;Control Groups;coping;Decision Making;Dementia;Dementia caregivers;Distress;efficacy evaluation;empowerment;Environment;Event;experience;Facebook;family burden;Family Caregiver;Feeling;Goals;Grief reaction;group intervention;health care service;hospice environment;improved;Individual;innovation;insight;interest;Intervention;intervention effect;Intervention Studies;Life;loved ones;Measures;Mediating;Medicare;Mental Depression;Methods;Mission;Modeling;Outcome;Patients;Persons;Population;Privatization;Qualitative Methods;Qualitative Research;Randomized;Randomized, Controlled Trials;Reaction;Reporting;Research;Resources;Services;Site;social;Social Impacts;social media;Social support;standard care;Stress and Coping;Technology;Testing;Thinking;Trauma;Treatment Efficacy;United States National Institutes of Health;Work

PROJECT_TITLE: Caregiver Speaks: A Technologically Mediated Storytelling Intervention for Family Caregivers ofIndividuals with Alzheimer's Disease and Other Dementias

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Substance Misuse

PHR: Narrative, Molecular Science Core We propose to mine single cell transcriptomics and epigenomics data to discover molecular markers for thalamic cell types and to build mouse transgenic and viral tools for genetic access to thalamic cell classes, subclasses or types. The markers and tools will be used in other research segments to investigate thalamic neuron connectivity, activity and function as soon as they become available. All the data, reagents, and transgenic animals will be made publicly available.

PI_NAMEs: TASIC, BOSILJKA  (contact)

PROJECT_TERMS: Adult;Amygdaloid structure;Anatomy;Animals;Area;ATAC-seq;Automobile Driving;Award;Axon;Basal Ganglia;Behavioral;bioinformatics tool;Brain;Brain imaging;BRAIN initiative;candidate marker;Cell Nucleus;cell type;Cells;cellular imaging;Censuses;Cerebellum;Chromatin;Corpus striatum structure;Data;Data Set;Databases;Dependovirus;Diffuse;DNA;Enhancers;epigenomics;excitatory neuron;Fluorescent in Situ Hybridization;Gene Expression;Genetic;genetic approach;genetic element;Genetic Enhancer Element;Genetic Markers;genomic data;Goals;Hippocampus;improved;Knock-in;Label;Logic;Maps;Measures;Midbrain structure;Modernization;Molecular;molecular marker;Morphology;Mus;Neocortex;neural circuit;Neurons;Organ;Pattern;Population;Process;public repository;Publishing;Reagent;recombinase;Recommendation;reconstruction;Regulatory Element;Reporter;Research;Role;Science;single cell genomics;single-cell RNA sequencing;Specificity;Standardization;Structure;Taxonomy;Techniques;Thalamic Nuclei;Thalamic structure;tomography;tool;transcription factor;transcriptomics;Transgenes;Transgenic Animals;Transgenic Mice;Transgenic Organisms;two-photon;Viral;Viral Genome;Viral Packaging;Viral Vector;Virus;Work

PROJECT_TITLE: Molecular Science Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

PI_NAMEs: LAUFFENBURGER, DOUGLAS A (contact)

PROJECT_TERMS: 2019-nCoV;Antibody titer measurement;Automobile Driving;Behavioral;Biological;Clinical;Cohort Studies;Collaborations;Communities;Community Outreach;Complex;Computer software;computerized tools;Computing Methodologies;Data;data integration;Data Set;Dimensions;Disease Outcome;Ebola;Epidemiology;Evolution;Experimental Designs;fitness;fundamental research;Goals;heterogenous data;high dimensionality;Immune;Immune response;Infection;insight;laboratory experiment;Lassa;long-term sequelae;mathematical methods;Mathematics;Measurement;Methodology;Methods;Mission;Modality;model building;Modeling;Molecular Epidemiology;multidimensional data;multidisciplinary;Nature;outcome prediction;pathogen;pathogenic virus;Patient-Focused Outcomes;Phylogenetic Analysis;Predictive Factor;Preventive;prognostic;Protocols documentation;Research;Research Personnel;social;statistical and machine learning;Statistical Methods;supervised learning;System;Systems Biology;T-Lymphocyte;Techniques;Technology;Therapeutic;tool;Training;unsupervised learning;Vaccination;Vaccines;Variant;variants of concern;Viral;Virus

PROJECT_TITLE: Modeling Core


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Narrative, Project 1 (Comprehensively map the mesoscale thalamic circuits that route subcortical inputs to frontal cortex) We will create a detailed circuit diagram connecting subcortical brain regions, non-sensory thalamus, and the frontal cortex. These circuits are critical for cognitive functions such as reward-dependent learning, short-term memory and movement planning. Mapping these circuits is also necessary for understanding disorders caused by damage to the thalamus, including cognitive and motor disorders, as well as coma and hypersomnia.

PI_NAMEs: MURPHY, GABE J (contact)

PROJECT_TERMS: Anatomy;Anterolateral;Area;Axon;Basal Ganglia;Behavior;Brain;Brain region;Cell Nucleus;Cells;Cerebellum;Code;Cognition Disorders;cognitive function;Coma;Communities;Computer Models;Coupled;Data;Decision Making;Disease;dynamic system;Electrophysiology (science);excitatory neuron;experimental study;Fluorescence;frontal lobe;Globus Pallidus;Hippocampus;Hypersomnias;Image;in vivo;Individual;Informatics;Label;Learning;Link;Location;Maps;Medial;Methods;Midbrain structure;Modeling;Motor Cortex;motor disorder;Movement;Mus;neural;neural circuit;neural patterning;Neurons;neurotransmission;novel;Output;Pathway interactions;Population;Prefrontal Cortex;Process;Prosencephalon;Proteins;Rabies;Recurrence;Reporter;Rewards;Route;Sensory;sensory cortex;Short-Term Memory;signal processing;Signal Transduction;Source;Standardization;Substantia nigra structure;Testing;Thalamic Nuclei;Thalamic structure;Viral;Virus;Work


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Neurosciences;Sleep Research;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: NARRATIVE Disruption of circadian rhythms can result in signficant physiological consequences inlcuding metabolic disorders and cancer. In these studies, we have identified a novel mechansim connecting disruption of circadian rhythms to disease etiology and developed a therapeutic intervention strategy to reduce health risk associated with circadian disruption.

PI_NAMEs: PORTER, WESTON W (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;Adult;Affect;Basal Cell;Behavior;beta catenin;Biological Clocks;Biological Models;Breast Epithelial Cells;cancer stem cell;cell behavior;Cell Differentiation process;cell growth regulation;Cell Lineage;cell type;Cells;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Data;Development;differential expression;Disease;Down-Regulation;Duct (organ) structure;Embryonic Development;Environment;Etiology;Eye;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Health;Heterogeneity;Homeostasis;Hormones;Intervention;Jet Lag Syndrome;Lactation;Light;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary gland;mammary gland development;MCF10A cells;Metabolic Diseases;Metabolism;Modeling;Molecular;Morphogenesis;Mus;neurotransmitter release;novel;Organism;Periodicity;Phenotype;Phosphoric Monoester Hydrolases;Physiological;Play;Population;Pregnancy;Process;Proliferating;Puberty;Regulation;Reporter;Risk;Role;self-renewal;Sensory;shift work;Signal Transduction;single-cell RNA sequencing;Sleep;Sleep Disorders;social;stem;stem cell biology;stem cell fate;stem cell homeostasis;stem cells;stroke risk;Testing;Therapeutic;Therapeutic Intervention;Time;Tissue Differentiation;transcription factor;Transforming Growth Factor beta;Vulnerable Populations;WNT Signaling Pathway;Working Women

PROJECT_TITLE: Circadian Regulation of Cellular Homeostasis

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse

PHR: Narrative, Project 2 (Produce the cell-type-specific thalamocortical projectome) We will uncover the diversity of thalamocortical (TC) neurons using detailed reconstructions of single cells and measuring their gene expression. We will then map molecular TC types across the thalamus using cutting-edge multiplexed spatial transcriptomics methods. These multi-modal datasets will provide the foundation for genetic access to specific TC types and provide the structural blueprint to understanding how subcortical areas influence cortical activity via the thalamus.

PROJECT_TERMS: Address;Ally;Anatomy;Anterior;Area;Atlases;Axon;Behavior;Brain;BRAIN initiative;Brain region;Categories;cell type;Cells;Censuses;Cerebellum;Classification;Color;Communities;Complex;Coupled;Data;Data Science Core;Data Set;Event;excitatory neuron;flexibility;Fluorescent in Situ Hybridization;Foundations;frontal lobe;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Markers;genetic selection;Goals;Hippocampus;Individual;Knowledge;Label;Lateral;Link;Location;Mammals;Maps;Measures;Medial;Methodology;Methods;Midbrain structure;Molecular;Morphology;Motor Cortex;Movement;multimodal data;multimodality;Multiregional Analyses;Mus;Neocortex;neural circuit;neural patterning;Neurons;Output;Pattern;Physiology;Prefrontal Cortex;Prosencephalon;reconstruction;Resolution;RNA;Science;Sensory;Shapes;Short-Term Memory;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Taxonomy;Thalamic Nuclei;Thalamic structure;tool;transcriptomics;transmission process;Work


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE (OVERALL) Retrotransposable elements (RTEs) are virus-like parasites that are permanently embedded in our bodies. We are born with them and we bear the consequences for our entire lives. RTEs are largely deleterious to our health but they are held in check by a variety of defenses. Recent research suggests that these mechanisms fail as we age and the consequent unleashing of RTEs promotes age-related diseases such as Alzheimer’s disease and related dementias. The goal of this program is to study and understand these processes so that we can develop therapies that will cure these devastating neurological disorders.

PI_NAMEs: SEDIVY, JOHN M (contact)

PROJECT_TERMS: Adult;Age;Age related macular degeneration;age-related disease;aged;Aging;aging process;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyotrophic Lateral Sclerosis;Anti-viral Response;Astrocytes;ATAC-seq;Autopsy;Behavioral;Benign;bioinformatics tool;Biological Models;Biology;Cell Aging;Cells;Central Nervous System;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Trials;Complementary DNA;Cytoplasm;Dementia;derepression;design;Detection;Disease;DNA Damage;Drosophila genus;Elderly;Elements;Epigenetic Process;Event;Failure;falls;Fibroblasts;Fright;Funding;gene therapy;Generations;Genetic;Genetic Screening;Genome;genomic locus;genomic tools;Goals;hallmarks of aging;Health;healthspan;Host Defense;Host Defense Mechanism;Human;Human Genome;human induced pluripotent stem cells;Image;immune activation;Immune signaling;in vivo;Induced pluripotent stem cell derived neurons;Inflammaging;Inflammation;inhibitor therapy;Innate Immune System;interest;Interferon Type I;Interferons;Invaded;Investigation;Length;Life Cycle Stages;life span;Link;Long Interspersed Elements;Long Terminal Repeats;Long-Term Effects;Malignant Neoplasms;member;Messenger RNA;Methods;Microglia;Modeling;Molecular;molecular imaging;mouse model;Mus;Mutation;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neuropathology;neurotoxicity;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;Nucleic Acids;Nucleosides;Organism;Parasites;parasitism;Paste substance;Pathology;Pathway interactions;Patients;Pharmacotherapy;Phenotype;postmitotic;Process;programs;Proteins;pseudotoxoplasmosis syndrome;Quality Control;Regulation;Repetitive Sequence;Reporter;Research;Research Personnel;Research Project Grants;response;Retrotransposition;Retrotransposon;Retroviridae Infections;Reverse Transcriptase Inhibitors;RNA-Directed DNA Polymerase;Role;Short Interspersed Nucleotide Elements;Signal Pathway;single molecule;single-cell RNA sequencing;Site;Somatic Cell;Standardization;stem cell model;Sterility;Stress;System;tau Proteins;technology platform;Testing;Therapeutic Intervention;therapy development;Tissue Harvesting;Tissues;tool;Transcript;transposon/insertion element;Untranslated RNA;Up-Regulation;Validation;Virus

PROJECT_TITLE: Role of Retrotransposon Activity in Neurodegeneration and Alzheimer's Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Vaccine Related

PI_NAMEs: GARRY, ROBERT F (contact)

PROJECT_TERMS: 2019-nCoV;Achievement;Acute;Africa;African;age difference;Antibodies;biosignature;Cessation of life;chronic infection;Clinical;clinical research site;Clinical Trials;cohort;Communicable Diseases;Coronavirus;Country;COVID-19;COVID-19 patient;COVID-19 survivors;Data;Data Set;data streams;Development;Diagnosis;Disease;Disease Outbreaks;Disease Outcome;Ebola;Ebola Vaccines;Ebola virus;Europe;experience;Goals;Hematology;heterogenous data;high throughput technology;Immune response;Immunize;Immunologic Factors;Immunologics;improved;Individual;Infection;Integration Host Factors;interest;Joints;large datasets;Lassa;Lassa virus;Lead;Long COVID;long-term sequelae;Machine Learning;Measurement;member;Metabolic;metabolome;Modeling;monitoring device;non-traditional data;Outcome;pathogenic virus;Pathogenicity;Pattern;personalized medicine;Phage ImmunoPrecipitation Sequencing;Physiological;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Predictive Factor;predictive modeling;prevent;racial difference;research clinical testing;response;Risk;RNA Virus Infections;RNA Viruses;SARS-CoV-2 infection;Serology;Severity of illness;Sex Differences;Sierra Leone;Survivors;Symptoms;Syndrome;System;Systems Biology;Technology;Test Result;Testing;Therapeutic;tool;United States;Vaccination;Vaccinee;Vaccines;Variant;Viral;Viral Hemorrhagic Fevers;Virus;Virus Diseases;Virus Latency;wearable data;wireless sensor;Work

PROJECT_TITLE: Project 1


PHR: Narrative, Project 3 (Impact of subcortical inputs on frontal cortex via thalamus) Subcortical brain regions send diverse functional signals to the frontal cortex, but how they are routed through non-sensory thalamus remains mysterious. Here we use a combination of in vivo and ex vivo electrophysiology and voltage imaging to study these connections in unprecedented detail. Our work will reveal the functional organization and physiological properties of connections important for cognitive and reward-related behaviors.

PI_NAMEs: CARTER, ADAM G (contact)

PROJECT_TERMS: Abbreviations;Anatomy;Behavior;behavior influence;Behavioral;behavioral study;Brain;Brain region;Cell Nucleus;cell type;Cells;Cognitive;Color;density;Electrophysiology (science);experimental study;Foundations;frontal lobe;Gene Expression;genetic approach;genetic signature;Globus Pallidus;Goals;Image;in vivo;Individual;Interneurons;Knowledge;Link;Medial;Modeling;Molecular;Motor Cortex;neural;neural circuit;neural model;Neurons;optogenetics;patch sequencing;Pathway interactions;Pharmacology;Physiological;Physiology;Population;Prefrontal Cortex;Property;Pyramidal Cells;response;Rewards;Route;Sampling;Science;segregation;sensory cortex;Signal Transduction;Site;Slice;Substantia nigra structure;Synapses;Testing;Thalamic Nuclei;Thalamic structure;tool;transcriptomics;Virus;voltage;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Narrative, Project 4 (Identify the schemata by which subcortical signals influence frontal cortical dynamics and cognitive behaviors) We perform high-density electrophysiological recordings in behaving mice to discover how subcortical brain regions influence frontal cortex via the thalamus and enable multiple cognitive behaviors. These studies are expected to lead to a conceptual framework of the non-sensory thalamus, which in turn will lead to an understanding of disorders caused by damage to the thalamus, including cognitive and motor disorders, as well as hypersomnia and coma.

PROJECT_TERMS: Anterior;Area;Automobile Driving;Axon;Basal Ganglia;Behavior;Behavioral;Body Weight Changes;Brain region;Calibration;Cell Nucleus;Cerebellum;Cognition Disorders;Cognitive;Coma;Complex;Coupled;Data;Data Science Core;density;Devices;Disease;dynamic system;Electrophysiology (science);excitatory neuron;experience;experimental study;flexibility;frontal lobe;Future;Globus Pallidus;Goals;Head;Hypersomnias;Intralaminar Nuclear Group;Lateral;Left;Link;Logic;Maintenance;Maps;Measurement;Medial;Medial Dorsal Nucleus;Mediating;Medical;Memory;Methods;Midbrain structure;Modeling;Modernization;Molecular;Motor;Motor Cortex;motor disorder;Movement;Multivariate Analysis;Mus;neural;neural circuit;neural patterning;Neurons;neurophysiology;optogenetics;Pattern;Phase;Population;predictive modeling;Prefrontal Cortex;Reagent;Recurrence;Research Project Grants;response;restraint;Rewards;Role;Science;Sensory;Short-Term Memory;Signal Transduction;Site;Statistical Methods;Structure;Substantia nigra structure;Synapses;Testing;Thalamic structure;Time;Update;Viral


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Many questions remain regarding the role of immunity in the etiology of cognitive decline and Alzheimer's Disease and related dementias (ADRD). Using the Health and Retirement Study (HRS), we will examine associations between peripheral immunosenescence and cognitive function, decline, and incident ADRD, with specific attention to social inequalities in these processes. At its conclusion, this study will yield critical insights to our understanding of the pathophysiology of cognitive decline and ADRD, creating new opportunities for early detection and targeting at the population level.

PI_NAMEs: AIELLO, ALLISON E;NOPPERT, GRACE A (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Adult;aging population;aging related;aging related disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;B-Lymphocytes;Biological;Blood;C-reactive protein;Cardiovascular Diseases;CD8B1 gene;Cells;Central Nervous System;Chronic;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cost;cytokine;Data;Dementia;dementia risk;Development;Diagnosis;diagnostic tool;Disparity;Disparity population;Early Diagnosis;Ethnic Origin;Etiology;executive function;frailty;Functional disorder;Gender;Goals;Health and Retirement Study;Immune;immune function;Immune system;Immunity;immunosenescence;Impaired cognition;improved;Individual;Inequality;Inflammation;Inflammatory;innovation;insight;Interleukin-6;Intervention;Language;Lead;Life Cycle Stages;Link;Longitudinal Studies;Malignant Neoplasms;Measures;Medicare;Medicare claim;Memory;monocyte;Natural Killer Cells;Non-Insulin-Dependent Diabetes Mellitus;nonalzheimer dementia;novel;novel diagnostics;older adult;Outcome;Pathway interactions;Patients;Peripheral;peripheral blood;Population;Population Heterogeneity;Population Study;Premature Mortality;prevent;Prevention strategy;Process;Protocols documentation;Race;Reporting;Research;Risk;Risk Factors;Role;Sampling;senescence;sex;social determinants;social disparities;socioeconomic disadvantage;Socioeconomic Status;Speed;Stressful Event;Surveys;T memory cell;T-Lymphocyte;Testing;TNF gene;Typology;Venous;Visuospatial

PROJECT_TITLE: Immunosenescence, socioeconomic disadvantage and dementia in the US aging population

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Meiotic recombination is a fundamental genetic and evolutionary process, whose successful completion is necessary for the production of egg and sperm. How meiotic recombination events are directed to the genome varies across vertebrates and remains poorly understood. By combining approaches from population genetics, genomics and phylogenetics, we will elucidate how recombination events are localized in the genome and how and why the mechanism differs across taxa.

PI_NAMEs: PRZEWORSKI, MOLLY F (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affinity;Alleles;ATAC-seq;Binding;Binding Sites;bioinformatics pipeline;Biological Assay;Birds;Candidate Disease Gene;candidate identification;Cells;ChIP-seq;Chromatin;Chromosome Mapping;comparative;Data;data integration;DNA Binding;Double Strand Break Repair;egg;Event;Evolution;Fishes;Frequencies;generative models;Genes;Genetic;Genetic Recombination;Genome;genome wide association study;genome-wide;Genomic approach;genomic data;Genomics;Germ Cells;histone modification;Histones;interest;Learning;Linkage Disequilibrium;Linkage Disequilibrium Mapping;Location;male;Mammals;Maps;Meiosis;Meiotic Recombination;Modeling;Mus;N-terminal;Northern Pike;novel;Orthologous Gene;Pattern;Phenotype;Phylogenetic Analysis;Phylogeny;Population Dynamics;Population Genetics;predictive modeling;Process;Production;promoter;recruit;repaired;Research Personnel;Role;single cell analysis;Snakes;Sorting;Specific qualifier value;sperm cell;Testing;Testis;transcriptome sequencing;Variant;Vertebrates;Work;zebra finch;Zinc Fingers

PROJECT_TITLE: Recombination rate variation and evolution in vertebrates

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Vector-Borne Diseases;Zika Virus

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Zika virus (ZIKV), an emerging human pathogen, causes congenital eye and neurological diseases, and we observed that ZIKV modulates the components of developmental Hippo signaling and energy sensor AMPK pathways in infected ocular cells. The molecular mechanisms of AMPK and Hippo pathway deregulation and the role of Zika viral virulence factors in ocular injury and development is poorly understood. We propose to elucidate the basic mechanisms of ZIKV mediated- deregulation of AMPK and Hippo pathways and cellular antiviral response using human ocular cell culture systems, retinal cup organoids, and mice models, which could yield novel insights into the pathogenesis of ZIKV ocular disease.

PI_NAMEs: ARUMUGASWAMI, VAITHILINGARAJA  (contact);KUMAR, ASHOK

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;5'-AMP-activated protein kinase;Ablation;Address;Affect;Anti-viral Response;Atrophic;Attenuated;Biological Models;Blood-Retinal Barrier;Brain Diseases;Cell Culture System;Cell Density;cell injury;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;Chemicals;Cicatrix;Code;conditioning;congenital eye disease;Cre lox recombination system;Cytometry;Cytoplasm;design;Development;Disease Progression;emerging human pathogen;Exhibits;experimental study;Eye;Eye Development;Eye diseases;Eye Injuries;fetal;Fetal Development;fetal infection;First Pregnancy Trimester;Functional disorder;fundus imaging;Genes;Genetic;Histology;Human;human induced pluripotent stem cells;human pathogen;Immune;In Vitro;in vivo Model;induced pluripotent stem cell;Inflammatory;Injury;innate immune pathways;Innate Immune Response;insight;Interferon-beta;Interferons;Knock-out;knockout gene;LATS1 gene;Link;Long-Term Effects;macula;Mediating;Metabolic;Metabolism;Modeling;Molecular;mouse model;Mus;Nervous System Disorder;novel;Ocular Pathology;organ growth;Organoids;Outcome Measure;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Pigments;Predisposition;primary outcome;Process;Proteins;Reflex action;Regulation;Reporting;Resources;Retina;Retinal Diseases;retinal progenitor cell;RNA chemical synthesis;Role;Second Pregnancy Trimester;sensor;Series;Signal Pathway;Signal Transduction;stem;stem cells;Stress;Structure of retinal pigment epithelium;TBK1 gene;Teratogens;Testing;therapeutic target;Tissues;transmission process;Tumor Suppressor Proteins;Viral;viral DNA;Viral Genome;Virulence Factors;Virus;Virus Replication;Vision;Visual impairment;ZIKA;Zika Virus;ZIKV disease;ZIKV infection

PROJECT_TITLE: Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

PHR: Narrative, Project 5 (Models of computation in multi-regional circuits with thalamus in the middle) The thalamus is the communication hub of the forebrain and plays key roles in cognitive functions such as decision-making, short-term memory, and voluntary motor control. Although subcortical areas influence cortical activity via the thalamus, we lack an understanding how the non-sensory thalamus routes information to influence cortex. Here we develop theoretical models of the interactions between subcortical areas, thalamus and cortex in the context of sensory and value-based decision-making. These models will provide a conceptual framework of the non-sensory thalamus, which in turn may lead to an understanding of disorders caused by damage to the thalamus, including cognitive and motor disorders, as well as hypersomnia and coma.

PI_NAMEs: WANG, XIAO-JING  (contact)

PROJECT_TERMS: Algorithms;Anatomy;Area;Automobile Driving;Basal Ganglia;Behavior;Behavior Control;Behavioral;Biological;Black Box;cell cortex;Cell Nucleus;cell type;Cerebellum;Choice Behavior;Cognition;Cognition Disorders;Cognitive;cognitive function;Collaborations;Coma;Communication;Computer Models;connectome data;data modeling;Decision Making;dimension reduction;Disease;driving behavior;dynamic system;excitatory neuron;experimental study;frontal lobe;Generations;Goals;Hypersomnias;in vivo evaluation;Laws;Learning;Light;Link;Maintenance;Maps;Memory;Methods;Midbrain structure;Modeling;Motor;motor behavior;motor control;motor disorder;Movement;Neocortex;network models;neural;neural circuit;Neurons;neurophysiology;Play;Population;predictive modeling;Prosencephalon;Recurrence;Research;response;Rewards;Role;Route;Sensory;Shapes;Short-Term Memory;Stimulus;Structure;Testing;Thalamic Nuclei;Thalamic structure;Theoretical model;theories;Update


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Narrative – Overall Component The overall goal of our Program is to understand how extracellular RNA is secreted and taken up by recipient cells to influence the development and aggressiveness of colorectal carcinomas (CRC). As CRC is the second most common cancer in the United States, we expect our work to highly impact human health.

PI_NAMEs: WEAVER, ALISSA M (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Address;Affect;Area;Behavior;Binding;Biogenesis;Biological;Biological Models;Biology;cancer initiation;Cell Communication;Cell membrane;Cell model;Cell Physiology;Cell secretion;cell type;Cells;Cetuximab;colonic crypt;Communication;Development;Endoplasmic Reticulum;Endosomes;Epidermal Growth Factor Receptor;Epigenetic Process;exosome;extracellular;extracellular vesicles;Funding;Gene Expression;Gene Expression Profile;Goals;Health;Human;Immune;inhibitor;intercellular communication;Intervention;Intestines;KRAS2 gene;Large Intestine Carcinoma;Ligands;Lipids;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Methods;MicroRNAs;microvesicles;Modification;Molecular;Neoplasm Metastasis;novel;Nucleic Acids;Organelles;Organoids;particle;Patients;Phenotype;Post-Translational Protein Processing;programs;Proteins;Repression;Resistance;Resource Sharing;RNA;RNA-Binding Proteins;Role;Signal Transduction;Signaling Protein;Sorting;stem cell niche;synergism;System;Testing;three dimensional cell culture;Tissues;trafficking;Transfer RNA;tumor microenvironment;tumor progression;tumorigenesis;United States;Up-Regulation;WNT Signaling Pathway;Work

PROJECT_TITLE: exRNA in colorectal carcinoma: biogenesis and function