NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Lung;Lung Cancer;Orphan Drug;Patient Safety;Prostate Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE An antigen known as DLL3 is expressed on the cell surface of two rapidly lethal types of cancer (small cell lung cancer and neuroendocrine prostate cancer) and can be targeted with a radiolabeled antibody that delivers radiation to the site of disease. This antibody, SC16.56, can be used for both diagnosis (with PET imaging) and therapy, using a theranostic approach akin to a military tank equipped with radar and an intelligence report to survey a territory, as well as a missile to launch a targeted attack. We will evaluate this antibody’s safety and treatment efficacy in patients with these two aggressive cancer types and assess tumor response using imaging and molecular genomic tools.

PI_NAMEs: BODEI, LISA  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: advanced prostate cancer;Affect;Aftercare;Antibodies;Antigens;Biological;Biopsy;Blood;bone;bone imaging;Cancer Etiology;Cancer Patient;cancer type;Cell surface;Cessation of life;Clinical;Common Terminology Criteria for Adverse Events;Data;Development;Diagnosis;Diagnostic;Disease;Dose;dosimetry;Exhibits;experience;Gene Expression;Genetic;genomic tools;Genomics;Goals;Golgi Apparatus;Image;Intelligence;Lesion;Ligands;Lung Carcinoma;Lung Neuroendocrine Neoplasm;male;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;men;Military Personnel;Modeling;Modification;Molecular;Molecular Profiling;Monitor;Monoclonal Antibodies;mortality;mutational status;Neoplasm Metastasis;neuroendocrine cancer;Neuroendocrine Carcinoma;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;Neurosecretory Systems;non-invasive monitor;noninvasive diagnosis;Normal tissue morphology;novel;Outcome Measure;overexpression;Patients;Pentetic Acid;Peptide Receptor;PET/CT scan;Pharmaceutical Preparations;phase 1 study;Phenotype;Positioning Attribute;Positron-Emission Tomography;Predisposition;prostate cancer model;Prostate carcinoma;Prostatic Neoplasms;Proteins;Radar;Radiation;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radioactive;Radioimmunoconjugate;Radiolabeled;Radionuclide therapy;Radiopharmaceuticals;RB1 gene;Reporting;response;Safety;safety and feasibility;Serious Adverse Event;Site;small cell lung carcinoma;Solid Neoplasm;Surveys;targeted agent;targeted imaging;theranostics;Therapeutic;therapy resistant;Tissues;tool;Toxic effect;TP53 gene;Transcript;Translations;treatment effect;Treatment Efficacy;treatment strategy;tumor;tumor heterogeneity;Tumor Markers;uptake;Validation;Visceral

PROJECT_TITLE: Characterizing the theranostic potential of DLL3-targeting agents in high-grade neuroendocrine carcinomas of the lung and prostate

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Rare Diseases;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE: The Undiagnosed Disease Network (UDN) is committed to ending the diagnostic odyssey for patients and families affected by undiagnosed disease. The proposed YDCoE brings together extensive clinical expertise, novel machine-learning clinical review tools, undiagnosed and rare disease discovery, next-gen sequencing and new approaches in bioinformatics and functional genomics to deliver clinical capacity for the UDN at unprecedented scale. Our strong community partnerships will ensure expanded access to individuals and groups who historically have not benefited from modern diagnostic investigations due to race, ethnicity, socioeconomic status or other systemic barriers.

PI_NAMEs: JIANG, YONG-HUI  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Affect;American;artificial intelligence model;Atlases;Bioinformatics;bioinformatics tool;Biological Assay;Caring;Cells;Clinical;clinical research site;cohort;Communities;community engagement;Community Healthcare;Community Networks;community partnership;Data Set;Dedications;Detection;Diagnosis;Diagnostic;Discrimination;Disease;disease-causing mutation;Economically Deprived Population;Enrollment;Ensure;epigenome;ethnic minority population;Ethnic Origin;Evaluation;exome sequencing;experience;Family;Foundations;functional genomics;Funding;gene discovery;Genetic;genetic disorder diagnosis;Genome;genomic variation;Goals;Grant;Health;health care service organization;health equity;Healthcare;Human Cell Line;Human Genetics;Immunobiology;Imprisonment;in vivo;Individual;Industry;industry partner;Infrastructure;innovation;Institution;Insurance;Intervention;Investigation;knowledge base;Lead;lens;Life;Machine Learning;Measures;Medical;Medical Genetics;medical specialties;Minority Groups;Modernization;Muscle;Natural Language Processing;next generation sequencing;novel;novel strategies;operation;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;patient population;Patient Recruitments;patient retention;Patients;perceived discrimination;Persons;Primary Care;Productivity;programs;Puerto Rico;Race;racial minority population;Rare Diseases;recruit;Reporting;Research;research clinical testing;Research Personnel;Resources;Secure;Services;Site;Social Work;Socioeconomic Status;Structure;systemic barrier;Third-Party Payer;Time;tool;Training and Education;Underserved Population;Uninsured;United States National Institutes of Health;Variant;Vulnerable Populations;Work;Xenopus

PROJECT_TITLE: Yale Diagnostic Center of Excellence for Undiagnosed Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative: Mosquitoes infected with the natural bacterium Wolbachia are increasingly released worldwide to curb the transmission of pathogenic Zika and dengue viruses to humans. Wolbachia rapidly spread through host populations by manipulating insect sexual reproduction including the development of sperm, eggs, and embryos. This research will characterize, for the first time, the initial epigenetic modifications during gametogenesis and embryogenesis that enable Wolbachia to spread, self-sustain at high frequencies, and protect local communities from mosquito-borne diseases.

PI_NAMEs: BORDENSTEIN, SETH R (contact);KAUR, RUPINDER

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: The Epigenetics of Cytoplasmic Incompatibility

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The blood-brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) by preventing the entry of harmful substances such as plasma proteins and inorganic solutes. This project is expected to result in a highly sensitive imaging tool that can detect and quantify subtle BBB dysfunction, with understanding of the underlying neurophysiological mechanisms.

PI_NAMEs: WANG, DANNY JJ (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;Age;age related changes;aged;Aging;Algorithms;Amyloid;Amyloid beta-42;Animal Model;aquaporin 4;Area;arterial spin labeling;Astrocytes;behavioral phenotyping;Benchmarking;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain region;Central Nervous System;Cerebral small vessel disease;Clinical Research;Cognitive;cohort;Compensation;contrast enhanced;Core-Binding Factor;Dedications;Diagnosis;Diffusion;diffusion weighted;Disease Progression;Early Diagnosis;Elderly;Endothelial Cells;Endothelium;Evaluation;Evolution;executive function;Extravasation;Gadolinium DTPA;Genotype;glymphatic function;glymphatic system;Goals;imaging biomarker;Imaging Device;improved;Individual;innovation;insight;Investigation;Knockout Mice;life span;Link;Magnetic Resonance Imaging;Mannitol;Maps;mathematical model;Measurement;Measures;Mediating;Membrane;Methods;Modeling;Molecular Weight;Motion;Mus;Neurodegenerative Disorders;neurophysiology;Neuropsychology;neurotoxic;normal aging;older adult;Outcome;Pathogenesis;Pathway interactions;Permeability;Physiologic pulse;Plasma Proteins;Play;Positron-Emission Tomography;potential biomarker;preclinical study;prevent;Protocols documentation;recruit;Resolution;Role;Safety;Scanning;Scheme;Signal Transduction;small molecule;solute;Surface;Techniques;Testing;Time;Tissues;tool;Tracer;validation studies;vascular cognitive impairment and dementia;Vascular Diseases;Veins;Venous;wasting;Water;water channel;Weight

PROJECT_TITLE: Non-invasive MRI mapping of BBB water exchange rate and permeability

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Patient Safety;Pediatric;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This research will determine how much high levels of insulin in the blood resulting from injecting insulin under skin causes three problems for the health of the heart and blood vessels. These three problems are stiffening of the blood vessels, more frequent blood clots, and using insulin less effectively. This study will see how much changing insulin levels in the blood affects these three risks in people with type 1 diabetes, people without diabetes, and people with a rarer form of diabetes called GCK-MODY.

PI_NAMEs: GREGORY, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: absorption;Acute;Affect;Antiatherogenic;Automobile Driving;Biological Availability;Blood;Blood coagulation;Blood Glucose;Blood Vessels;Bypass;Canis familiaris;Cardiac health;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cessation of life;Circulation;Clinical Trials;Data;Development;diabetes management;Diabetes Mellitus;Disease Outcome;disorder risk;Endothelial Cells;Endothelium;experimental study;Face;Foundations;Functional disorder;Glean;Glucokinase;Glucose;Glucose Clamp;glucose disposal;glycemic control;Glycosylated hemoglobin A;Goals;Hepatic;high risk;Hour;Human;Hyperglycemia;Hyperinsulinism;Iatrogenesis;improved;Individual;inhibitor;insight;Insulin;insulin mediators;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Liver;Longevity;Matched Group;maturity onset diabetes of the young;Measures;Mediating;Mediator;Methods;mortality;Natural History;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;Pancreas;Participant;Patients;Peripheral;Persons;Physicians;Physiological;Pilot Projects;Play;Quality of life;Research;Resolution;response;Risk;Risk Marker;Role;Route;Severities;Skin;Sodium;stable isotope;stem;subcutaneous;symporter;Techniques;Testing;thrombotic;Tissues;tool;Tracer;ultrasound;uptake;Vasodilation;volunteer

PROJECT_TITLE: Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project narrative Our proposed research seeks to elucidate the intricate dynamics of social networks and their impact on health- related behaviors and the early detection of cognitive impairment, specifically Alzheimer's Disease and Related Dementias (ADRD). By employing advanced methodologies in data science and social network analysis, the study aims to uncover the mechanisms through which social ties influence behavior change and care-seeking efforts. The ultimate goal is to inform the development of more precise and targeted interventions and campaigns that can enhance health promotion and ADRD detection strategies within at-risk communities.

PI_NAMEs: FUJIMOTO, KAYO ;MYNENI, SAHITI  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Affect;Alzheimer's disease related dementia;Archives;Attitude;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;behavioral construct;brain health;care providers;care seeking;Caring;Characteristics;Chronic Disease;Code;Cognitive Science;Communicable Diseases;Communication;Communities;comorbidity;Computer Assisted;Consultations;Data;Data Analyses;Data Science;Death Rate;deep learning;Delirium;density;Detection;Development;diabetes management;Diagnosis;Diffusion;digital;digital communication;digital platform;Disease;Early Diagnosis;Ego;Etiology;experience;Family member;Goals;Guidelines;Health;Health behavior;Health Care Seeking Behavior;Health Personnel;Health Promotion;Hemorrhage;Human;human old age (65+);Impaired cognition;improved;Individual;Informatics;information model;Information Resources;information seeking behavior;insight;Interpersonal Relations;Intervention;Interview;Knowledge;Link;Major Depressive Disorder;Manuals;Maps;Measures;Methodology;Methods;middle age;Misinformation;Modeling;Modification;Natural Language Processing;Nature;network models;novel;online community;Parents;Pathology;Pathway Analysis;Pathway interactions;Patient Care;Patient Self-Report;Patients;peer;peer influence;Persons;Physical activity;Play;Population;pressure;Process;Public Health;Research;Research Methodology;Research Proposals;Resistance;Risk;Risk Behaviors;Risk Reduction;Risk Reduction Behavior;Role;Science;self reported behavior;Services;Shapes;sleep quality;social;Social Behavior;social capital;social influence;social media;Social Network;social norm;Social Processes;social relationships;social structure;Source;Structure;Surveys;Symptoms;Texas;Theoretical model;theories;United States;Vitamin Deficiency;Work

PROJECT_TITLE: Informatics-enhanced Social Networks and Affiliation Processes (ISNAP) to promote risk reduction and early diagnosis of Alzheimer's and Related Dementias.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A1)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Neurosciences;Rare Diseases;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE Undiagnosed rare disease negatively impacts patient quality of life, causes disproportionate health care utilization, and creates a tremendous economic burden for the patient and the health care system. Genomic medicine carries the promise of improving diagnosis, care, and therapeutics for individuals with rare disease but limited access to genomic medicine carries a risk of health inequity. This project proposes to improve the identification, care and diagnostic modalities for patients with rare disease.

PI_NAMEs: CONBOY, ERIN ;VETRINI, FRANCESCO ;WARE, STEPHANIE M (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;Bioinformatics;Biological Assay;care outcomes;Caring;Child;Cities;Clinic;Clinical;clinical care;clinical diagnostics;cohort;Collaborations;Communities;Community Health;Computational Science;Copy Number Polymorphism;Detection;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;disease diagnostic;Economic Burden;Educational Status;Elderly;Enrollment;Epigenetic Process;Equity;Evaluation;exome;exome sequencing;General Population;Genes;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Services;genetic testing;Genome;genome sciences;genome sequencing;Genomic medicine;Genomics;Geography;Goals;Health;health care disparity;health care service utilization;health disparity;health inequalities;health literacy;Health Sciences;Health Services Accessibility;Healthcare Systems;Hospitals;Human;Immigrant community;implementation science;improved;Income;Indiana;Individual;innovation;Investments;Kansas;medical schools;Medical Students;Medicine;member;Metabolic;Methods;Methylation;Mitochondria;Modality;Modeling;Molecular;Molecular Diagnosis;multidisciplinary;multimodality;multiple omics;Neonatal Intensive Care Units;neonate;novel;Ontology;Outcome;Participant;Pathogenicity;Patient Care;patient screening;Patients;Persons;Phase;Phenotype;Population;Population Heterogeneity;programs;Proteome;Proteomics;Public Health;Qualifying;Quality of life;rare condition;Rare Diseases;rare genetic disorder;Recording of previous events;Reporter;Research;research clinical testing;Resources;Risk;Role;Rural Population;safety net;screening;Sensitivity and Specificity;Short Tandem Repeat;Site;socioeconomic disparity;System;Technology;teleconsultation;telehealth;Testing;Therapeutic;therapy development;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Uncertainty;underserved community;United States;Universities;Urban Health;Variant;variant of unknown significance

PROJECT_TITLE: Indiana Collaborative for Undiagnosed Rare Disease


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: Cryptosporidium is one of the most important causes of diarrheal disease in the U.S. and around the world. This project will reveal the mechanisms that underlie parasite persistence and host specificity.

PI_NAMEs: STRIEPEN, BORIS  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Biological Assay;Biology;Cells;Child Health;chlorination;Communities;Complex;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Data;Development;diarrheal disease;Disease;drug development;Drug resistance;effective therapy;enteric pathogen;Environment;Epidemiology;Evolution;Experimental Models;Exposure to;forward genetics;gene function;Genes;Genetic;genetic analysis;Genetic Crosses;Genetic Population Study;Genetic Recombination;Genetic study;Genome;gut microbiome;Home;Human;Human Cell Line;Immune;Immunocompetent;Immunosuppression;Individual;Infant Mortality;Infection;innovation;insight;Internet;Intestines;Invaded;Life Cycle Stages;Maps;Modeling;Molecular;Morphology;Mus;new technology;novel drug combination;Nutritional status;Opportunistic Infections;Organoids;Parasites;pathogen;Pathogenesis;Persons;Phenotype;population survey;Predisposition;Prophylactic treatment;Quantitative Trait Loci;Recombinants;Reproduction spores;Research;Resistance;reverse genetics;Risk;Risk Factors;Safety;Series;sex;Side;Specificity;stem cells;System;Testing;transmission process;vaccine development;Variant;Virulence;Water;waterborne outbreak;Zoonoses

PROJECT_TITLE: Genetic Analysis of Cryptosporidium

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Pediatric

ORG_CITY: ROOTSTOWN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: Project narrative Brain circuits that compute sound source location using relative timing and intensity are critical for speech comprehension in noisy environments and are altered in children with central auditory processing disorder (CAPD). The lateral superior olive (LSO) is a key component of this system traditionally thought to resolve intensity differences, however, evolutionary drive for the calyx of Held and recent evidence suggest the major function of the LSO is encoding time differences particularly for broadband transients. To address this conundrum, we will clarify cellular diversity in the LSO that is not well understood which we propose allow it to perform both functions and may be dysregulated by hearing loss or CAPD.

PI_NAMEs: WINTERS, BRADLEY D (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Address;Affect;Attention;attenuation;Auditory;Bilateral;Brain;Brain Stem;Calcium;Cell Extracts;cell type;Cells;Central Auditory Processing Disorder;Child;Childhood;childhood hearing loss;Code;Complex;Comprehension;Computer Models;Conductive hearing loss;Coupling;Data;Dendrites;density;design;Disease;Disparate;Ear;Electrophysiology (science);Environment;Equilibrium;experimental study;Fire - disasters;Gene Expression;Goals;hearing impairment;Image;Impairment;improved;in vivo;Individual;Inferior Colliculus;innovation;insight;Ion Channel;Ipsilateral;Kinetics;Knowledge;lateral superior olive;Life;Location;Mammals;Measures;Membrane;Methodology;models and simulation;Morphology;mouse model;Mus;Neurons;Neurotransmitters;Otitis Media;Output;patch clamp;patch sequencing;Pattern;Phase;Property;response;Role;Signal Transduction;sound;Sound Localization;Source;Speech;Stimulus;Synapses;synergism;System;Techniques;Testing;Time;transcriptome;transcriptomics;two-photon;Update;voltage gated channel

PROJECT_TITLE: Cellular diversity in the superior olivary complex underlying timing- and intensity-based sound localization

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Digestive Diseases;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The proposed project is relevant to public health because congenital diaphragmatic hernia (CDH) is a relatively common birth defect of the lungs associated with high mortality and morbidity. There remains a critical need to better understand CDH disease pathogenesis and to identify novel treatment options to improve the lives of affected children. The data generated from this proposal using rodent lung explants, human organoids, micro- mechanical technologies, and large animal models will enhance our understanding of the impact of a major mechanosensory pathway during the canalicular stage of fetal lung development.

PI_NAMEs: KUNISAKI, SHAUN MICHAEL (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Abdomen;Acceleration;Address;Affect;Animal Model;Animals;Biology;Cells;Cellular biology;Child;Clinical;clinical translation;Congenital Abnormality;Congenital diaphragmatic hernia;Critical Care;Data;Death Rate;Defect;Development;Devices;Disease;disease phenotype;Distal;Down-Regulation;Engineering;Epithelium;Extracorporeal Membrane Oxygenation;Family;fetal;Fetal Lung;fetus surgery;FGF10 gene;Goals;Growth;Growth and Development function;Growth Factor;Human;human model;human stem cells;Impairment;improved;in utero;in vivo;induced pluripotent stem cell;innovation;Intestines;Ipsilateral;Liver;Lung;lung basal segment;lung development;lung pressure;mechanical force;Mechanics;mechanotransduction;Mediating;Modeling;Morbidity - disease rate;Morphogenesis;mortality;mouse model;Mus;Neonatal Intensive Care Units;neonate;Neptune;new therapeutic target;nitrofen;novel;Nuclear;Operative Surgical Procedures;Organ;Organoids;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Phosphotransferases;Play;pre-clinical;prenatal therapy;pressure;Proteins;Public Health;Pulmonary Hypertension;pulmonary hypoplasia;Pulmonary Pathology;Regulation;Research;Rodent;Role;Severity of illness;sheep model;Signal Pathway;Signal Transduction;Stimulus;Structure of parenchyma of lung;Technology;Thoracic cavity structure;Trachea;Transcription Coactivator;Transcriptional Coactivator with PDZ-Binding Motif;Up-Regulation;Ventilator;Work

PROJECT_TITLE: Modeling fetal lung development in congenital diaphragmatic hernia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Lupus

ORG_CITY: GALVESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative Lupus nephritis is a debilitating complication of systemic lupus erythematosus. Most patients are currently treated with medications that have significant side effects and novel therapeutics are urgently needed. The studies proposed here will test a new type of targeted therapeutic and will lead to its development as a novel treatment for lupus nephritis patients in the future.

PI_NAMEs: GUPTA, VINEET  (contact);NIEWOLD, TIMOTHY B

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;Affect;Agonist;Albuminuria;anti-dsDNA antibodies;Antigen-Antibody Complex;Antitumor Response;Attention;Biological;Biological Assay;Biological Availability;Biological Markers;Biological Process;Cells;Clinical Trials;Code;Complication;Cytotoxic agent;Data;Deposition;Development;Disease;Dose;efficacy trial;End stage renal failure;follow-up;Future;Genetic;Goals;Human;IL6 gene;Immune;Immunosuppressive Agents;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammation Mediators;Inflammatory;inflammatory marker;Injury to Kidney;Integrins;Interferon Type I;Interleukin-6;Intervention;IRF3 gene;ITGAM gene;Kidney;Kidney Diseases;Link;Literature;Lupus;Lupus Nephritis;Measures;Medical;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;mycophenolate mofetil;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Myeloproliferative disease;Neoadjuvant Therapy;NF-kappa B;novel;novel therapeutics;Oncology;Oral;Outcome;Pathway interactions;Patients;personalized approach;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase I/II Clinical Trial;pilot trial;Placebo Control;Proteins;Proteinuria;Receptor Signaling;recruit;renal damage;Renal function;Renal glomerular disease;response;restraint;Risk;Risk Factors;Role;Safety;Serum;side effect;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;small molecule;Systemic Lupus Erythematosus;Tablets;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Use Study;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;Toxic effect;Translating;tumor;Variant

PROJECT_TITLE: Translating oral CD11b agonist as a novel therapeutic for lupus nephritis

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE A substantial proportion of breast cancer survivors report fear of cancer recurrence following cancer treatment, yet few interventions utilizing scalable eHealth methods and targeting fear of recurrence have been empirically evaluated. The purpose of this large, multisite phase III randomized clinical trial is to evaluate whether an eHealth intervention (“FoRtitude”) that teaches cognitive behavior therapy- based coping strategies and healthy behaviors tailored to manage fear of recurrence, can reduce fear of recurrence, depression, and anxiety; improve quality of life; and reduce fear of recurrence-related health care utilization and physiologic dysregulation (allostatic load).

PI_NAMEs: WAGNER, LYNNE I. (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Access to Information;Address;Adherence;allostatic load;American College of Radiology Imaging Network;Anxiety;arm;attentional control;base;Behavior;Behavioral;Black race;Breast Cancer survivor;cancer recurrence;cancer subtypes;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer type;Caring;Chronic stress;Cognitive;Cognitive Therapy;cohort;Communities;Community Clinical Oncology Program;Coping Skills;cost;Coupled;Data;design;Diagnosis;Diet and Nutrition;Dissemination and Implementation;Distress;Eastern Cooperative Oncology Group;Educational process of instructing;effective intervention;efficacy evaluation;eHealth;Emotional;Enrollment;Ensure;evidence base;Expectancy;Face;Female Breast Carcinoma;follow-up;Fright;Geography;health assessment;health care service utilization;health management;health related quality of life;Healthcare;Hispanic;improved;Individual;individualized medicine;interactive tool;Intervention;intervention delivery;Link;Lived experience;Long-Term Survivors;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mental Depression;Methods;Minority;mortality;motivational enhancement therapy;Not Hispanic or Latino;Occupations;Outcome;Participant;Patients;Persons;Phase;Physiological;Population;Positioning Attribute;post intervention;preference;Prevalence;programs;Provider;psychologic;Psychosocial Assessment and Care;Quality of life;Race;racial diversity;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reading;recruit;Recurrence;Relaxation;Reporting;Research;Risk;Sampling;Schedule;secondary endpoint;Self Efficacy;Site;Stress;Subgroup;success;Survivors;telecoaching;telephone based;therapy design;Time;treatment as usual;usual care arm;virtual;web site;Woman;Work

PROJECT_TITLE: Randomized controlled trial of FoRtitude: Targeted eHealth intervention to reduce fear of recurrence among breast cancer survivors in community oncology settings

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND STATE UNIVERSITY

PHR: Project Narrative This research will develop a unique multi-functional 3D printed dental implant that will effectively minimize peri- implantitis, i.e., dental implant-related infection incidences for patients needing artificial tooth/teeth. This unique infection-resistant and bioactive dental implant can also be tailored according to patient defects. They will relieve patients from the baleful aftermaths of infections, such as surgical pain, repeated clinic visits for treatment, prolonged recovery time, reliability on antibiotics, and added therapy costs.

PI_NAMEs: SIKDER, PRABAHA  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: 3D Print;Address;Affect;age acceleration;Allergic Reaction;Anatomy;Animal Model;Anti-Bacterial Agents;Antibiotics;Artificial Tooth;Bacteria;Biocompatible Materials;Biological Assay;Biological Sciences;biomaterial compatibility;Biomedical Engineering;Biopolymers;Bone Regeneration;Bone Tissue;Cephalic;Clinic Visits;Clinical;clinical translation;Collaborations;cost;craniofacial;Defect;Dental;Dental Implants;Dentistry;Development;Diameter;efficacy evaluation;Engineering;Environment;Escherichia coli;Exhibits;fabrication;Failure;Family suidae;Fatigue;Feasibility Studies;Femur;Filament;Future;Gingival Bleeding on Probing;Gingival Recession;Goals;Growth;Hemorrhage;Heterogeneity;High temperature of physical object;Histology;Human;Immunologist;Implant;implant associated infection;implantation;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;Infection;infection risk;innovation;inorganic phosphate;Ions;Ligature;Magnesium;manufacture;maxillofacial;mechanical properties;Mechanics;medical implant;Metals;Methods;Microbial Biofilms;Modeling;multidisciplinary;nanoparticle;Nature;novel;Oral;oral infection;oral pathogen;Orthopedics;Osseointegration;Osteoblasts;Osteomyelitis;particle;Patients;Performance;peri-implantitis;Periodontal Diseases;physical science;polyetheretherketone;polymicrobial biofilm;porcine model;preclinical efficacy;Prevalence;prevent;Property;Protocols documentation;Rattus;reconstruction;Recovery;Research;Research Personnel;Resistance;Resistance to infection;Resolution;Rodent;Scientist;Silver;Site;Staphylococcus aureus;Structure;Surface;surgical pain;systematic review;Taxes;Techniques;Testing;Time;Titanium;Tooth Loss;Tooth structure;Translating;treatment choice;Vertebral column

PROJECT_TITLE: Multi-functional 3D Printed Dental Implants for Preventing Peri-implantitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Back Pain;Bioengineering;Biomedical Imaging;Chronic Pain;Disability Research;Neurosciences;Osteoarthritis;Pain Research;Regenerative Medicine

ORG_DEPT: ORTHOPEDICS

PHR: Back pain has become the most common cause of disability globally and is the primary contributor to healthcare spending in the USA. The intervertebral disc and the facet joints act in concert to permit mechanical function of the healthy spine, however, both structures are prone to degeneration which can contribute to back pain. This proposal will bring a new perspective to the study of spinal degeneration by investigating the crosstalk between the disc and facets during both degeneration and repair, enhancing our understanding of the pathophysiology of spinal degeneration and contributing to the future development of more effective treatments for patients with back pain.

PI_NAMEs: GULLBRAND, SARAH E (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acute;Age;age related;Animal Model;Animals;Anterior;Articular Range of Motion;Articulation;Back Pain;Biochemical;Biological;biomechanical test;Biomechanics;Biomedical Engineering;Cadaver;capsule;Cartilage;Cervical;Cervical spine;Chondroitin ABC Lyase;Complex;Cross-Sectional Studies;Data;Degenerative polyarthritis;Development;Diagnostic;disability;Disease;dorsal column;Early treatment;effective therapy;Elements;Euthanasia;Facet joint structure;Female;Finite Element Analysis;Freedom;Friction;Functional disorder;Future;Goat;Health;Healthcare;Height;Histology;Human;human tissue;Hyaluronic Acid;Hydrogels;immune cell infiltrate;improved;in vivo;Inflammation;Injectable;Injections;Injury;Intervertebral disc structure;intervertebral disk degeneration;Joints;Knowledge;Length;Link;Magnetic Resonance Imaging;male;mechanical properties;Mechanics;minimally invasive;Modeling;Motion;Musculoskeletal;Natural regeneration;Nerve;nerve supply;neural;nucleus pulposus;Outcome;Outcome Measure;Pain;Pain Measurement;Pathogenesis;Pathology;Patient-Focused Outcomes;Patients;Pattern;Physiological;Play;Postoperative Period;Process;Proteoglycan;quantitative imaging;Radiology Specialty;Regenerative Medicine;repaired;Research;Resistance;sex;sex as a biological variable;Spinal;Spinal Cord;Stains;Stress;Structure;subchondral bone;Surface;Surgeon;Synovial Membrane;Time;Tissue Engineering;Tissue Model;Tissues;vertebra body;Vertebral column;Veterinarians;Weight-Bearing state;women versus men;Work;years lived with disability

PROJECT_TITLE: Disc-Facet Crosstalk During Spinal Degeneration and Repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke;Unintentional Childhood Injury

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Intraventricular hemorrhage induces inflammation and brain injury in premature neonates and there is no treatment. This proposal is designed to develop a better understanding of how intraventricular hemorrhage alters neuroimmune function and white matter development.

PI_NAMEs: MILLER, BRANDON A (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acute;Affect;ANK3 gene;Antigens;Axon;axon injury;Bioenergetics;Blood;blood product;Brain;brain cell;Brain Injuries;Cd68;Cell Communication;Cell Culture Techniques;Cell division;Cell Maturation;Cell Physiology;Cell Separation;Cells;Cerebral Ventricles;Child;Clinical Trials;clinically relevant;CNTNAP1 gene;CSPG4 gene;cytokine;Data;design;Development;Developmental Delay Disorders;Diffusion;efficacious treatment;Enzyme-Linked Immunosorbent Assay;Erythrocytes;Event;excitotoxicity;experience;Exposure to;Failure;Family;Flow Cytometry;Functional disorder;Genes;glial activation;Glycolysis;Goals;Health;Hemoglobin;Human;Immune;immune activation;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;Innate Immune System;Insulin-Like Growth Factor I;Insulin-Like Growth Factor II;intraventricular hemorrhage;ITGAX gene;Label;lateral ventricle;Lifelong disability;Macrophage;Magnetic Resonance Imaging;Measures;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Myelin;myelination;Natural Immunity;Neonatal;Neonatal Brain Injury;neonate;Nervous System Disorder;Neuroimmune;neuroimmunology;neuroinflammation;Neurological disability;NF-kappa B;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Oxidative Phosphorylation;Oxidative Stress;Pathology;pharmacologic;Phenotype;Platelet-Derived Growth Factor;Predisposition;Premature Birth;preterm newborn;Production;Rattus;Resolution;response;Role;Site;Source;Stem Cell Development;stem cell fate;stem cell survival;stem cells;Survivors;targeted treatment;Testing;Time;Ventricular;white matter;white matter injury;Whole Blood

PROJECT_TITLE: IGF-1 and Innate Immunity in Neonatal Brain Injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Idiopathic Pulmonary Fibrosis is a devastating lung disease that causes progressive scarring in the lungs resulting in respiratory failure and death. The research described in this grant proposal aims to understand how lung scarring can be reversed in Idiopathic Pulmonary Fibrosis. The proposed research is relevant to public health because a better understanding of the biology underpinning scar reversal has the potential to identify new therapeutic targets for the treatment of this disease and other diseases of progressive scarring.

PI_NAMEs: PODOLSKY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Alveolar;Anabolism;Applications Grants;arm;Binding;Biology;Cell Surface Receptors;Cells;Cessation of life;Cicatrix;Collagen;Collagen Receptors;Collection;CRISPR screen;Critical Pathways;Data;Deposition;Development;Diagnosis;Disease;Disease Progression;Down-Regulation;Dyspnea;Endoplasmic Reticulum;Equilibrium;Exhibits;experimental study;extracellular;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Gases;Gatekeeping;Genes;Genetic Transcription;genome-wide;Goals;Grant;Health;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;indium-bleomycin;insight;Integral Membrane Protein;Knockout Mice;Knowledge;Lung;Lung Diseases;Mediating;Mediator;member;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmacotherapy;prevent;Process;profibrotic fibroblast;Progressive Disease;Proteins;Protocols documentation;Public Health;Publishing;Pulmonary Fibrosis;pulmonary function;receptor;reduce symptoms;Regulation;repository;Research;Resolution;Respiratory Failure;sensor;single-cell RNA sequencing;Structure of parenchyma of lung;success;Testing;Therapeutic;therapeutic development;therapeutically effective;tissue repair;Tissues;transcription factor;United States;uptake;Work

PROJECT_TITLE: Intracellular Collagen Sensing in Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative / Public Health Relevance Candida frequently forms biofilms on the surface of medical devices. Both drug resistance and dissemination due to fungal cell dispersion contribute to the high mortality linked to biofilm infections; there are no effective drug therapies for these commonly lethal fungal infections. The proposed studies will uncover the biofilm driven regulatory pathway and effectors that govern the extracellular vesicle delivery and assembly of the protective matrix that permits Candida to persist and disseminate from implanted devices.

PI_NAMEs: ANDES, DAVID R (contact);MITCHELL, AARON P

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Animals;anti-fungal agents;Back;Biogenesis;Biological Assay;Biological Process;Biology;Candida;Candida albicans resistance;candida biofilm;cell community;Cell Survival;Cells;Clinical;Collaborations;Complex;Defect;Drug resistance;Drug Targeting;effective therapy;Endosomes;Exhibits;Extracellular Matrix;extracellular vesicles;Fluconazole;Funding;Fungal Drug Resistance;gene network;Genes;Genetic;genetic effector;implantable device;in vivo;Infection;innovation;insight;Investigation;Libraries;Life;Link;loss of function;Mediating;Medical Device;Microbial Biofilms;Modeling;mortality;mutant;Mycoses;novel;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;polymicrobial biofilm;Predisposition;preservation;Production;Proteomics;public health relevance;Regulatory Pathway;Research;Resistance;resistance mechanism;Role;skills;Sorting;Surface;Technology;Testing;tool;transcription factor;transcriptomics;Vesicle;Virulence

PROJECT_TITLE: Vesicle-mediated drug resistance of Candida albicans biofilm


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

PHR: NARRATIVE The proposed study will generate population-based data on the impact of false-positive findings from lung cancer screening with low dose computed tomography for the 14.5 million U.S. adults eligible for screening. These results have the potential to inform patient and clinician shared decision-making conversations and future US Preventive Services Task Force evidence reviews. As the number of patients screened for lung cancer increases due to expanded eligibility criteria, this research is timely and responsive to the National Cancer Institute’s goal to support research in cancer control that will help inform guideline development and policy decisions.

PI_NAMEs: HENDERSON, LOUISE  (contact);RIVERA, MARIA PATRICIA ;STOVER, ANGELA M

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Age;aged;American College of Radiology;Anxiety;Asian;Attitude;Behavior;Benign;Biopsy;Black race;Cancer Control;Cancer Detection;cancer diagnosis;Cancer Etiology;Caring;Cessation of life;Characteristics;Classification;Clinical;Communities;Data;Data Collection;data registry;Data Reporting;Data Sources;Decentralization;Development;Economics;Eligibility Determination;Ensure;Ethnic Origin;experience;Family;financial toxicity;follow-up;Fright;Future;Goals;Guidelines;Healthcare;Healthcare Systems;Image;Individual;Information Systems;Intervention;Interview;Knowledge;Latino;Lesion;Link;low dose computed tomography;Lung;lung cancer screening;lung imaging;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;medical specialties;Methods;Modeling;mortality;National Cancer Institute;neoplasm registry;New York;Nodule;North Carolina;patient screening;Patients;Performance;Policies;Population;population based;Population Characteristics;Primary Care;Procedures;prospective;psychologic;Race;radiologist;Recommendation;Recording of previous events;Reporting;Research;Research Support;Risk;risk/benefit ratio;routine screening;Sampling;screening;screening program;Screening Result;sex;shared decision making;Site;Smoke;Smoking History;Smoking Status;Source;standard of care;Statistical Models;Surgeon;Surveys;System;therapy development;Training;United States Preventative Services Task Force;Variant;Woman;Work

PROJECT_TITLE: Lung Cancer Screening: Cumulative Risk and Multilevel Impact of False Positive Findings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Genetic mutations in the transcription factor networks that govern eye development are a leading cause of congenital ocular malformations. The proposed studies in this project seek to elucidate novel insights into the mechanisms through which key regulatory circuits active in retinal progenitor cells contribute to the proper production of retinal neurons. This information is critical for a better understanding of the etiology of retinal developmental disorders and for potentially improving diagnosis and management.

PI_NAMEs: AL DIRI, ISSAM  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Anophthalmos;Binding;Biological Assay;Blindness;Case Study;Cell Differentiation process;Cell Proliferation;cell type;Child;Chromatin;Chromatin Remodeling Factor;Communities;Competence;Complex;conditional knockout;Data;Development;developmental disease;Diagnosis;Differentiated Gene;Distal Enhancer Elements;DNA;DNA Binding;DNA Sequence Alteration;Electroporation;Elements;Enhancers;Epigenetic Process;Etiology;Event;Eye Development;Eye diseases;EZH2 gene;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Transcription;genome-wide analysis;Genomic approach;Genomics;Goals;Growth;HMG-Box Domains;Human;improved;in vivo;innovation;insight;Knockout Mice;Knowledge;Lead;malformation;Maps;Microphthalmos;Molecular;Morphogenesis;mouse model;Mus;Mutate;Mutation;Mutation Analysis;nerve stem cell;neural;Neurodevelopmental Disorder;novel;Nucleic Acid Regulatory Sequences;Outcome;prevent;Process;Production;programs;recruit;Regulatory Element;Resolution;Retina;Retinal Diseases;retinal neuron;retinal progenitor cell;retinogenesis;Role;single cell technology;Site;SMARCA4 gene;Source;stem cell proliferation;SWI/SNF Family Complex;Syndrome;Technology;Tertiary Protein Structure;Testing;Therapeutic;transcription factor;Transgenic Organisms;Untranslated RNA;Vision

PROJECT_TITLE: Wiring and rewiring of the chromatin landscape during retinogenesis

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PHR: PROJECT NARRATIVE This project will leverage clinical and omics data in the Women’s Health Initiative to identify epigenetic biomarkers for cardiovascular disease risk prediction in African American women. The study is expected to provide insights into risk prediction in this high-risk population, which may have implications for precision medicine.

PI_NAMEs: CARDENAS, ANDRES ;FRANCESCHINI, NORA  (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;adjudication;African American;African American population;African American Women;African Women;aging clocks;Alcohol consumption;Behavioral;Biological;Biological Aging;Biological Factors;Biological Markers;Blood;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cells;Chronic;Clinical;clinical care;Clinical Data;clinical risk;cohort;Collaborations;Coronary heart disease;Data;Data Reporting;Discrimination;disorder risk;Disparity;DNA Methylation;Environment;Environmental Exposure;Epigenetic age;epigenetic aging;epigenetic marker;Epigenetic Process;epigenome;Equation;Event;genome wide association study;genomic locus;Genomic Segment;Genotype;Goals;health difference;high risk;high risk population;Immune;improved;Inflammatory;insight;Lead;Life Style;lifestyle data;lifestyle factors;lifetime risk;men;Methylation;methylation biomarker;Mission;Modeling;Modification;Morbidity - disease rate;mortality;mortality risk;National Heart, Lung, and Blood Institute;novel strategies;Outcome;Participant;Patient Self-Report;Performance;Population;population health;Postmenopause;precision medicine;predictive tools;programs;Proteomics;Reproducibility;Research;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;Role;Sampling;Smoking;Stroke;stroke risk;Testing;Toxic Environmental Substances;Trans-Omics for Precision Medicine;United States National Institutes of Health;Validation;Woman;Women's Health;women's outcomes

PROJECT_TITLE: Epigenetic biomarkers of cardiovascular risk in African American Women

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Orphan Drug;Patient Safety;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE Many patients with drug-resistant tuberculosis in high-burden settings receive suboptimal treatment due to the lack of access to drug-susceptibility tests or long delays in receiving test results. The proposed research describes the development of a clinical decision support tool to optimize the empiric treatment of patients with rifampicin-resistant tuberculosis based on patient characteristics, the local epidemiology of drug-resistant tuberculosis, and the cost and toxicity of anti-TB drugs.

PI_NAMEs: YAESOUBI, REZA  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Accounting;Adoption;Age;analytical tool;Antibiotics;Cessation of life;Characteristics;Clinical;clinical care;Clinical Data;clinical decision support;Clinical Trials;Communities;cost;cost effective;cost effective treatment;cost effectiveness;Country;Data;Decision Modeling;demographics;design;Development;Diagnosis;disability-adjusted life years;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Drug toxicity;effective therapy;Effectiveness;effectiveness evaluation;Ensure;Epidemic;evidence base;fluoroquinolone resistance;Fluoroquinolones;follow-up;Health Services;Health Status;High Prevalence;high risk;improved;Incidence;Individual;individualized medicine;Kazakhstan;Laboratories;Machine Learning;machine learning algorithm;Methods;Modeling;Moldova;Molecular;Morbidity - disease rate;mortality;Multi-Drug Resistance;Mycobacterium tuberculosis;Notification;optimal treatments;Patient Care;Patient-Focused Outcomes;Patients;Peru;Pharmaceutical Preparations;Pharmacoepidemiology;Physicians;point of care;Policy Maker;Population;predictive modeling;Predisposition;Prevalence;Probability;Process;programs;prototype;Public Health;Quality of life;randomized, clinical trials;rapid detection;rapid test;Recommendation;Recording of previous events;Regimen;Research;Research Personnel;residence;Resistance;resistant strain;Resources;Rifampicin resistance;Risk;risk prediction model;routine care;rural area;side effect;spatiotemporal;Specialist;Standardization;support tools;System;Test Result;Testing;tool;Toxic effect;Translating;transmission process;Treatment Cost;treatment duration;Treatment Effectiveness;Treatment Failure;treatment guidelines;Treatment outcome;Treatment Protocols;Treatment-related toxicity;Tuberculosis;tuberculosis drugs;tuberculosis treatment;urban area;usability;user centered design;Vietnam;World Health Organization

PROJECT_TITLE: A clinical decision tool to optimize the selection of antibiotics for patients with rifampicin-resistant Tuberculosis

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE The p53 tumor suppressor and phosphoinositide (PI) 3-kinase (PI3K)/Akt pathway are key regulators of cell growth and apoptosis and frequently mutated in cancer. We have discovered a nuclear PI3K/Akt pathway independent of the canonical pathway whereby PIs are linked to p53 in response to stress to activate nuclear Akt and inhibit cell death. PIs are also linked to MDM2, a key regulator of p53 stability, allowing for fine tuning of the p53-MDM2 pathway. The molecular characterization of this nuclear PI3K/Akt pathway and PI-regulated p53- MDM2 pathway could lead to new strategies to treat cancer.

PI_NAMEs: ANDERSON, RICHARD A. (contact);CRYNS, VINCENT L.;PETI, WOLFGANG

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;AKT Signaling Pathway;Apoptosis;Binding;Biological;Breast Cancer Model;Cancer Biology;Cell Death Inhibition;cell growth;Cell model;Cell Nucleus;Cell Survival;Clinic;Clinical;Complex;Dose;Drug Targeting;Enzymes;Family member;Generations;Genetic Transcription;Genomics;Genotoxic Stress;Heat shock proteins;Inositol;inositol polyphosphate multikinase;insight;kinase inhibitor;Label;Ligase;Link;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;MDM2 gene;Membrane;Membrane Lipids;Metabolic;Modeling;Modification;Molecular;mouse model;mutant;Mutate;novel;Nuclear;Oncogenic;Outcome;Pathway interactions;PDPK1 gene;PH Domain;Phosphate-Binding Proteins;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PI3 gene;Proliferating;Protein Kinase;Proteins;PTEN gene;Publications;Reaction;recruit;Regulation;response;Role;scaffold;SERPINA4 gene;Signal Transduction;Site;Specimen;Stress;Testing;Therapeutic;therapeutic target;TP53 gene;tumor growth;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppression;Tumor Suppressor Proteins;ubiquitin ligase

PROJECT_TITLE: Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor Progression

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) is a consortium of clinical centers and a Data Coordinating Center studying the cause and treatment of MASH, formerly termed NASH, in order to prevent known outcomes of cirrhosis, liver transplant and liver cancer. Our studies have identified noninvasive measures for diagnosis, prognosis and prevention of disease. Our center aims to continue being the major site for the completion of major studies and have enrolled the largest number of children and minorities in the Network.

PI_NAMEs: LOOMBA, ROHIT  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3-Dimensional;Address;Adult;Advanced Development;Affect;Asian;Biological Markers;biomarker validation;California;candidate validation;Cessation of life;Child;Childhood;Cirrhosis;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Data;Data Coordinating Center;Databases;Detection;Diagnosis;Diagnostic;diagnostic development;Disease;Disease Progression;disorder prevention;Dose;effective therapy;Enrollment;Etiology;FDA approved;Fibrosis;Funding;Goals;Hepatic;Hepatology;high risk;Hispanic;Histologic;Image;improved;innovation;Liver diseases;Liver Fibrosis;liver transplantation;longitudinal database;Longitudinal Studies;Malignant neoplasm of liver;Measures;Metabolic dysfunction;metabolomics;microbial;Minority;Modality;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;noninvasive diagnosis;novel;Outcome;Participant;participant enrollment;Pathogenesis;Pathology;Population;Prediction of Response to Therapy;prevent;Prevention;Primary carcinoma of the liver cells;Prognosis;public-private partnership;Publications;Radiology Specialty;Reading;recruit;Registries;repository;Research;Research Personnel;Resolution;response;Risk;Sampling;Scanning;Serum;Site;Steatohepatitis;Translational Research;translational study;United States;Universities;Validation;viscoelasticity;Visit;Vitamin E;Work;Yin

PROJECT_TITLE: Clinical Research on Nonalcoholic Fatty Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M2)]


NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Hypertension;Infectious Diseases;Liver Disease;Microbiome;Nutrition

ORG_CITY: TOLEDO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Project Narrative Gut microbiota is now recognized as a critical, previously ignored factor contributing to the development of hypertension. However, the mechanisms by which gut microbiota regulates hypertension is a significant knowledge gap. In this proposal, building on our recently published data, we address this knowledge gap on conjugated bile acids, which are products of collaborative biochemical processing by gut microbiota and the host. The proposal uses cutting-edge animal models as tools to understand the mechanism by which gut microbiota- mediated conjugated bile acids operate as antihypertensive metabolites.

PI_NAMEs: JOE, BINA  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acids;Address;Age;American Heart Association;amidase;Animal Model;Anti-Hypertensive Agents;Antibiotics;attributable mortality;Bile Acids;Biochemical;Biochemistry;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;cardiovascular risk factor;Ceramide Signaling Pathway;Ceramides;Clinical;Collaborations;Communities;CRISPR/Cas technology;Data;Development;dietary salt;dysbiosis;Energy Metabolism;Enzymes;Epidemic;Epithelial Cells;experimental study;Female;Genes;Genetic;Genetic Models;Genetic Transcription;Germ-Free;Goals;gut microbiota;Health;human disease;human model;human mortality;Hypertension;hypertension treatment;hypertensive;ileum;insight;Institution;Integration Host Factors;Intestines;knock-down;Knock-in;Knock-out;Knowledge;Laboratories;Light;Link;Liver;male;Mass Spectrum Analysis;Mediating;Metabolic;metabolomics;Microbe;microbiota;Modeling;Modernization;modifiable risk;Monitor;novel;novel therapeutic intervention;Nutritional;Pathway interactions;Patients;Physiological;Plasma;Population;Predisposition;Production;Publishing;Rattus;receptor;Resources;restoration;Risk Factors;Rodent Model;salt intake;salt sensitive;serine palmitoyltransferase;Small Interfering RNA;Sphingomyelinase;Stroke;Taurocholic Acid;Testing;Therapeutic;tool;United States;Update;Veillonella;villin;Volatile Fatty Acids;Work

PROJECT_TITLE: Conjugated bile acids as nutritionally re-programmable antihypertensive metabolites

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE The many biological and environmental factors influencing recovery from pediatric traumatic brain injury (TBI) are poorly understood, resulting in inaccurate prediction of outcomes and few effective treatments. This project will investigate DNA methylation/the “methylome”, a major epigenetic regulator of gene expression, as an untapped source of biologic complexity underlying recovery from pediatric TBI. The overall impact of this work will be to improve our understanding of the biologic complexity underlying pediatric TBI recovery, reveal biologic signatures of risk for poor recovery, and identify potential methylomic biomarkers that could revolutionize TBI management.

PI_NAMEs: TREBLE-BARNA, AMERY  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acquired disability;Acute;Adult;aged;bead chip;biobank;Biological;Biological Factors;Biological Markers;Blood specimen;Body mass index;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Child;Clinical;Clinical Management;Clinical Research;clinical research site;clinical translation;cohort;comparison group;Data;Decision Making;Development;Disease;Disease Outcome;Disparity;DNA Methylation;effective therapy;Enrollment;Environment;Environmental Risk Factor;Epigenetic Process;Ethnic Origin;feasibility testing;Future;Gene Expression;Gene Expression Regulation;Genes;health equity;Heterogeneity;high dimensionality;Impairment;improved;Individual;injured;Injury;Longitudinal Studies;Mediating;Mediation;Mediator;Medical;Methylation;methylome;methylomics;neurobehavioral;Neuronal Plasticity;new therapeutic target;novel;Orthopedics;Outcome;outcome prediction;pediatric traumatic brain injury;Phenotype;pre-clinical;Precision Health;precision medicine;Process;prognostic model;prognostic tool;protective effect;protein biomarkers;psychosocial;Puberty;Race;Recovery;Regulator Genes;Rehabilitation therapy;Reproducibility;Research;Resources;response;Risk;Role;Science;Scientific Inquiry;Severities;Signal Transduction;Site;Smoking;social health determinants;Source;targeted biomarker;Technology;Testing;Therapeutic;therapy development;Time;Tissues;tool;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment response;Work

PROJECT_TITLE: Methylomics of pediatric traumatic brain injury and neurobehavioral recovery

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Patient Safety;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Overuse of total thyroidectomy exposes patients with thyroid cancer to unnecessary risks without improving length or quality of life. This study will address this problem by testing an intervention for surgeons and practice leaders comprised of existing evidenced-based interventions tailored for thyroid cancer treatment. Because thyroid cancer is the most common malignancy in young adults, the proposed intervention could reduce rates of unnecessary total thyroidectomy and improve long-term outcomes of survivors including quality of life.

PI_NAMEs: PITT, SUSAN C (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;adverse outcome;Algorithms;Attitude;Award;Awareness;behavior change;Behavior Therapy;Behavioral Model;Behavioral trial;cancer risk;cancer surgery;Cancer Survivor;cancer therapy;Caring;Climate;Clinical;Cluster randomized trial;Collaborations;Collection;Communication;Consensus;Data;Deimplementation;design;Disease;disorder risk;Education;effective intervention;effectiveness testing;effectiveness/implementation trial;Ensure;Ethnography;evidence base;Evidence based intervention;Expectancy;expectation;experience;Fatigue;Feedback;Funding;Future;Goals;Guidelines;Health;health related quality of life;Hybrids;implementation strategy;improved;Intervention;intervention effect;intervention refinement;Intervention Trial;Interview;Length;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Medical;Mental Depression;Methods;Michigan;Mission;Morbidity - disease rate;Morphologic artifacts;motivational enhancement therapy;multidisciplinary;novel;Obesity;Operative Surgical Procedures;Outcome;overtreatment;Patient-Focused Outcomes;Patients;Phase;Physicians;Policies;Positioning Attribute;practice factors;pragmatic trial;preference;prevent;primary outcome;Process;Provider;psychosocial;Publishing;Quality of life;Randomized;randomized, clinical trials;Recording of previous events;Recurrence;Research;Risk;secondary outcome;Self Efficacy;Site;skills;skills training;Structure;Surgeon;Survivors;Testing;Theoretical model;therapy design;therapy development;Thyroid Gland;Thyroidectomy;Time;tool;Training;Treatment outcome;user centered design;Visit;Work;young adult

PROJECT_TITLE: A Multi-level Intervention to Reduce Total Thyroidectomy Overuse for Low-Risk Cancer

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Personality traits have been linked to the cognitive healthspan, compression of cognitive morbidity, Alzheimer’s Disease and Related Dementias, and tolerance of Alzheimer’s brain pathology. It is essential to understand more precisely the pathways through which personality traits and ADRD are related; the current application therefore focuses on the role of potential mediators (i.e., inflammatory biomarkers, cardiometabolic biomarkers), as well as socioeconomic risk factors as potential moderators. The use of multiple large longitudinal datasets of aging and dementia will enhance replicability of results, and will be guided by theoretical frameworks of differentiated preservation, preserved differentiation, cognitive reserve, as well as compression of morbidity in late life.

PI_NAMEs: MROCZEK, DANIEL K. (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Age;Aging;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Autopsy;Biological Markers;biological systems;Black American;Blood Pressure;Brain;brain health;Brain Pathology;C-reactive protein;Cardiac health;cardiometabolism;Clinical;clinical diagnosis;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive reserve;Compensation;Country;Data;Data Analyses;Data Set;Decision Making;Dementia;dementia risk;Development;Diagnosis;Disadvantaged;Disparity population;Early identification;economic disparity;Economics;Epidemiology;Future;Health;healthspan;Impaired cognition;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;innovation;interest;Interleukin-6;Intervention;Knowledge;late life;Link;longitudinal dataset;Longitudinal Studies;low socioeconomic status;Measurement;Mediating;Mediation;Mediator;Modeling;Morbidity - disease rate;mortality;neuropathology;Neurotic Disorders;novel;older adult;Outcome;outcome prediction;Pathology;Pathway interactions;Personality;Personality Character;Personality Traits;Policy Maker;preservation;Prevention;preventive intervention;Preventive Medicine;Race;rate of change;Research;Research Personnel;resilience;Resources;response;Risk;Risk Factors;Role;Route;Sampling;social disparities;Social support;socioeconomics;Testing;theories;Time;Tissue Sample;trait;Work

PROJECT_TITLE: Personality Prediction of Dementia Risk and Progression

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


PHR: Cystic fibrosis (CF) results from mutations in the CFTR Cl- channel resulting in diminished transepithelial Cl- secretion. The most common CFTR mutation, F508del, results in a channel that fails to correctly fold/traffic. FDA- approved compounds that improve the folding/trafficking of misfolded CFTR have been identified as part of a highly effective modulator therapy (HEMT) - referred to as correctors. These correctors are highly efficacious in improving lung function. Unfortunately, adverse events (AE) have been reported in a subset of CF patients taking these correctors, including headache, hypertension and mental health issues. We demonstrate CFTR correctors inhibit small (KCa2.x) and intermediate (KCa3.1) conductance, Ca2+-activated K+ channels (KCa) while also potentiating the large (BKCa; KCa1.1) conductance KCa. Our studies will define the mechanisms by which CFTR correctors modulate KCa channel function and how this affects ion transport across human bronchial epithelial cells (HBEs), vascular reactivity and neuronal action potential firing. As this HEMT represents the standard of care for CF patients it is critical to understand the mechanisms underlying the AE reported, both in the short- term, so they may be mitigated, and in the long-term such that next-generation HEMT may be developed – improving the lives of CF patients.

PI_NAMEs: DEVOR, DANIEL C (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: absorption;Action Potentials;Acute;Adverse event;Affect;Affinity;airway surface liquid;Anxiety;Aorta;Arteries;Biochemical;Blood Vessels;brain fog;bronchial epithelium;Calcium-Activated Potassium Channel;Cell Physiology;Cells;Chemosensitization;Cyclic AMP;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Delta F508 mutation;Dependence;design;disease-causing mutation;drug action;Electrophysiology (science);Epithelial Cells;FDA approved;fluorescence imaging;Forskolin;Frequencies;Headache;Hippocampus;Human;Hypertension;Impairment;improved;In Vitro;Ion Transport;Light;Mediating;Mental Health;Mesenteric Arteries;Molecular;Moods;Mus;Mutation;Myography;neuronal excitability;Neurons;next generation;patch clamp;Patch-Clamp Techniques;patient subsets;Pharmacologic Substance;Physiology;Potassium Channel;pressure;Proteins;pulmonary function;Quality of life;Reporting;response;Role;Series;Sleeplessness;standard of care;Techniques;Therapeutic;Time;trafficking;Treatment Efficacy;Vascular Smooth Muscle;Vasodilation;VX-770

PROJECT_TITLE: Modulation of Ca2+ -activated K+ channels by CFTR Correctors

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Although it has been long hypothesized that -cell heterogeneity is highly relevant to the risk of diabetes, the nature and mechanism of such heterogeneity is largely unknown. Our previous study suggested that HNF1A, a key transcription factor that causes early onset diabetes in young people, may also contribute to common type II diabetes via governing -cell heterogeneity. In this project we will comprehensively investigate the function and mechanism of HNF1A-driven -cell heterogeneity in multiple -cell models.

PI_NAMEs: LI, YAN  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Address;Admixture;Age;Algorithms;ATAC-seq;Beta Cell;Biology;Body mass index;Cell Differentiation process;Cell Line;Cell model;Cell Physiology;Cells;Chemicals;Complex;Consensus;Data;Diabetes Mellitus;diabetes risk;Disease;dosage;Dropout;early onset;Enhancers;Gender;Generations;Genes;Genetic;genetic signature;Genetic Transcription;Genome Mappings;Genomic approach;genomic data;Heterogeneity;Hi-C;Human;human embryonic stem cell;Impairment;improved;Individual;individual variation;insight;islet;Life Style;Link;Literature;Maps;Measurement;Measures;Mediating;Modeling;Molecular;Molecular Disease;Molecular Profiling;Morphology;Multiomic Data;multiple omics;Mutation;Nature;Non-Insulin-Dependent Diabetes Mellitus;patch sequencing;Persons;Play;Population;Publishing;Regulation;Reporter;Reporting;Research;Resolution;Risk Factors;Role;Sampling;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Sorting;stem cell model;Structure of beta Cell of islet;Surveys;System;Testing;Therapeutic;Time Factors;Transcript;transcription factor;transcriptome;transcriptomics;type I and type II diabetes;Variant;Work

PROJECT_TITLE: Comprehensive characterization of HNF1A-driven beta-cell heterogeneity

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Aging;Brain Disorders;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative  This research project seeks to uncover the critical role of hepatocyte-specific necroptosis in liver inflammation, liver pathology, and cognitive decline in the context of aging. By investigating the impact of necroptosis on liver inflammation, cellular senescence, and neuroinflammation, the study aims to shed light on the intricate interplay between the liver and the brain in aging. The findings have the potential to uncover new insights into the mechanisms promoting age-related cognitive impairment and could lead to innovative interventions targeting hepatocyte-specific necroptosis to mitigate cognitive deficits associated with age-related conditions.

PI_NAMEs: SATHYASEELAN, DEEPA  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adult;Affect;Age;age related;Age-associated memory impairment;age-related disease;Aging;aging related;Autophagocytosis;Behavioral;Brain;Cell Aging;Cell Culture Techniques;Cell Death;cell type;Cells;Chronic;chronic liver disease;Cognition;Cognitive;Cognitive deficits;cognitive function;cytokine;Data;Development;Elderly;Encephalitis;Exhibits;experimental study;Fibrosis;glial activation;hallmarks of aging;Health;Hepatocyte;Hippocampus;HMGB1 gene;Human;human old age (65+);Immune;Impaired cognition;Impairment;improved;In Vitro;in vivo;Inflammaging;Inflammation;Inflammatory;inhibition of autophagy;inhibitor;innovation;insight;Intervention;Knock-in Mouse;Knockout Mice;Light;Link;Liver;Liver diseases;liver inflammation;liver transplantation;Macrophage;Macrophage Activation;Measures;Mediating;Mediator;Molecular;mortality;mouse model;Mus;Neuroglia;neuroinflammation;NF-kappa B;novel;old mice;Outcome;Pathology;Pathway interactions;Pattern;pharmacologic;Phenotype;Process;promoter;Recombinants;release factor;Research Project Grants;response;Role;senescence;Source;Testing;TLR4 gene;Transcription Factor AP-1

PROJECT_TITLE: The role of hepatocyte necroptosis and inflammation in liver-brain crosstalk in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-S (02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Public Health Relevance Our study is designed to test the hypothesis that lowering hepatic nitrogenous waste burden can help reduce the progression of hepatocellular carcinoma. This will provide a new molecular connection between ammonia waste and liver cancer development, and will potentially identify nitrogen burden as a risk factor and therapeutic/preventive target for HCC.

PI_NAMEs: ZONG, WEI-XING  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;Ammonia;Ammonium;Anabolism;Binding;Blood;CCAAT-Enhancer-Binding Proteins;cell growth;Clinical Data;Coupled;Curiosities;Data;design;Development;Dietary Intervention;Down-Regulation;Drug Metabolic Detoxication;Enhancers;enzyme activity;Enzymes;Event;Excision;Excretory function;feeding;Genetic;Genetic Transcription;Glutamate Dehydrogenase;Glutamate-Ammonia Ligase;Glutamates;Glutamine;Goals;Growth;Growth and Development function;gut microbiome;Hepatic;Hexosamines;Histologic;HNF4A gene;Homeostasis;Hyperammonemia;In Situ;in vivo;Intercellular Fluid;knock-down;Ligase;Literature;Liver;liver ablation;liver cancer model;Malignant neoplasm of liver;Malignant Neoplasms;Mammals;mass spectrometric imaging;Mediating;Metabolic;Metabolism;metabolome;metabolomics;Molecular;mouse model;Mus;neurotoxic;Neurotoxins;Nitrogen;Non-Essential Amino Acid;novel;Oncogenic;Organ;Outcome;overexpression;Pathologic;Pathway interactions;Patients;Plasma;Play;Polyamines;prevent;Prevention;Prevention strategy;Preventive;Primary carcinoma of the liver cells;Production;Prognosis;promoter;Protein-Restricted Diet;public health relevance;Publications;Purines;Pyrimidine;Pyrimidines;Regulation;Reporting;Risk Factors;Role;Signal Transduction;SP1 gene;Sp1 Transcription Factor;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Symptoms;Techniques;Testing;Therapeutic;Tissues;transcription factor;transcriptome;tumor;tumor growth;Tumor Promotion;tumorigenesis;Urea;urea cycle;wasting;Work

PROJECT_TITLE: Defective urea cycle promotes oncogenesis of hepatocellular carcinoma

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BURLINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative The proposed research is relevant to public health because it is focused on the neural mechanisms of intrusive traumatic memories, a hallmark symptom of post-traumatic stress disorder (PTSD). The proposed research will examine the functional contribution of cortical regions to complex behavior across multiple levels of analysis (cell, physiology, behavior). The project is relevant to NIMH’s mission because it will provide new knowledge about the neural bases of learning, memory, and emotion, which may relate to clinical symptoms when dysfunctional.

PI_NAMEs: BARRY, JEREMY MICHAEL;TODD, TRAVIS  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Air;Anterior;Area;base;Behavior;Behavioral;Brain region;Cells;cingulate cortex;Clinical;Code;Complex;conditioned fear;conditioning;Cues;Development;Disease;Electrophysiology (science);Emotions;Event;Exhibits;experience;experimental study;Exposure to;fear memory;Flying body movement;Foundations;Fright;Genetic;Head;Hippocampus;in vivo;Injury;Knowledge;Learning;Link;long term memory;Memory;memory encoding;memory retrieval;Methods;Mission;National Institute of Mental Health;Nature;neural;neuromechanism;Neurons;novel;Pathologic;Patients;Phase;Physiology;Positioning Attribute;Post-Traumatic Stress Disorders;post-traumatic symptoms;preconditioning;Process;Property;Psychological reinforcement;Public Health;Rattus;Research;response;Response to stimulus physiology;Retrieval;Role;Sampling;Sensory;Sensory Process;Services;Signal Transduction;sound;Stimulus;Structure;support network;Symptoms;System;Testing;theories;Thinking;Time;Translational Research;Trauma;traumatic event;Veterans;Work

PROJECT_TITLE: Cortical Networks Encoding Higher-Order Memories that Elicit Fear

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity

PHR: PROJECT NARRATIVE Altered hepatic lipid synthesis and catabolism can adversely affect local and systemic lipid homeostasis. While the critical role of insulin in promoting hepatic lipid and lipoprotein synthesis is widely studied, major knowledge gaps exist regarding hormones that suppress hepatic lipogenesis and promote fat oxidation. Our discovery that CTRP1 is a novel endocrine (from adipose) and/or paracrine (from liver) regulator of hepatic lipid synthesis and catabolism may provide a novel therapeutic target to treat non-alcoholic fatty liver disease (NAFLD) and non- alcoholic steatohepatitis (NASH).

PI_NAMEs: WONG, GUANG WILLIAM (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: acylcarnitine;ADD-1 protein;Address;adenoviral mediated;Adipose tissue;Affect;aged;Attention;bariatric surgery;Biological;Biology;Catabolism;cell type;Clinical;Clinical Research;Complement 1q;Data;defined contribution;Diet;diet-induced obesity;Disease;disease phenotype;Endocrine;Enzymes;Event;experimental study;Family;Fat-Restricted Diet;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Foundations;FRAP1 gene;Funding;gain of function;Gene Expression;Genes;Genetic;Glucose Intolerance;Hepatic;Hepatocyte;Hepatomegaly;High Fat Diet;Homeostasis;Hormone secretion;Hormones;improved;in vivo;Inflammation;innovation;insight;Insulin;Insulin Resistance;knock-down;Knock-out;Knockout Mice;Knowledge;Link;lipid biosynthesis;lipid metabolism;Lipids;Lipoproteins;Liver;loss of function;Maps;Mediating;Metabolic;Metabolic Control;Metabolism;metabolomics;Mitochondria;Morbid Obesity;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Nuclear;obese patients;Obesity;Organ;overexpression;oxidation;paracrine;Pathway interactions;Phenotype;phosphoproteomics;Plasma;Play;Process;programs;Proteins;Proteomics;Respiration;Role;Severities;Signal Transduction;single-cell RNA sequencing;SIRT1 gene;Source;sugar;Testing;Tissues;TNF gene;tool;Tracer;transcriptome sequencing;transcriptomics;Transgenic Mice

PROJECT_TITLE: CTRP and Metabolic Control

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because TP53 is the most commonly mutated gene in human cancers and understanding how TP53 mutations alter malignant tumors and normal tissues to spread to other organs may help to identify associated vulnerabilities that can be used for therapy. Our proposed research is therefore highly relevant to the core mission of the NIH to develop fundamental knowledge to help reduce the burden of disease and cancer.

PI_NAMEs: KIM, MICHAEL PAUL (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;Address;Adenocarcinoma Cell;Applications Grants;attenuation;Automobile Driving;beta catenin;Binding;Biological Models;burden of illness;cancer cell;Cell Surface Receptors;Cells;Chemoresistance;chemotherapy;clinical diagnosis;Clinical Oncology;combinatorial;Complex;Cyclic AMP-Responsive DNA-Binding Protein;Data;Deposition;Development;Diagnosis;Disease;Disease remission;Distant;Drug Delivery Systems;drug efficacy;efficacy testing;Elements;Extracellular Matrix;FGF2 gene;Fibroblasts;Fibrosis;gain of function;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genetically Engineered Mouse;Goals;HIF1A gene;Human;improved;innovation;insight;Knowledge;KRAS oncogenesis;Laboratories;Ligands;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mission;Modification;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Organ;Organoids;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Prevalence;prevent;Primary Neoplasm;protein complex;Proteins;Public Health;Research;response;Role;Signal Pathway;Signal Transduction;Site;Systemic disease;Testing;Therapeutic;Therapeutic Effect;TP53 gene;Translating;translational therapeutics;Translations;treatment strategy;tumor;Tumor Burden;tumor microenvironment;Tumor Promotion;Tumor Suppressor Genes;Tumor Tissue;United States National Institutes of Health;Up-Regulation;Wnt1 Protein;WNT11 gene;Work

PROJECT_TITLE: Defining pro-metastatic drivers in the pancreatic cancer tumor microenvironment

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE STATEMENT The societal and patient-centered impacts of osteoarthritis (OA) are profound – total costs for OA treatment in the US exceed $486 billion annually. OA management is limited to pain management and the disease often progresses to end-stage at which time only joint replacement surgery is an option. Elucidating gaps in our understanding of the role of genetic variation to OA susceptibility, heterogeneity, and progression will enable the design personalized approaches for diagnosis and care management to improve quality of level for OA patients.

PI_NAMEs: MCDONALD DONNELLY, MERRY-LYNN NOELLE (contact);SINGH, JASVINDER A

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Age;Alleles;ancestry analysis;Area;biobank;Body mass index;Caring;Chromatin;Code;cohort;cost;Country;Data;Degenerative polyarthritis;design;Development;Diagnosis;Disease;Electronic Health Record;Ensure;Etiology;Exposure to;Fingers;Frequencies;Genes;Genetic;genetic association;Genetic Determinism;Genetic Risk;genetic variant;Genetic Variation;Genome;genome wide association study;genomic data;genomic locus;Genomics;Genotype;Goals;Hand;Healthcare Systems;Heritability;Heterogeneity;Hip region structure;Hispanic;improved;Inflammation;Intervention;Joint by Site;Knee;knee replacement arthroplasty;Life Cycle Stages;male;Managed Care;Manuscripts;Maps;Mediating;moderate obesity;novel;Obesity;Occupational;Operative Surgical Procedures;Pain;Pain management;Participant;Patient Care;patient oriented;patient stratification;Patients;personalized approach;Phenotype;Predisposition;Prevalence;Prevention strategy;Process;programs;public health relevance;Quantitative Trait Loci;rare variant;Replacement Arthroplasty;Research;Risk;Risk Factors;Risk Reduction;risk stratification;risk variant;Role;secondary analysis;Seminal;sex;sexual dimorphism;symptom management;Testing;Therapeutic Intervention;Time;trait;Trans-Omics for Precision Medicine;treatment strategy;Variant;Vertebral column;Veterans;Weight maintenance regimen;whole genome;Woman;Women's Health;Wrist

PROJECT_TITLE: Genetics of Osteoarthritis Susceptibility, Heterogeneity and Progression

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Patient Safety;Pediatric;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE This research will contribute to public health efforts to improve treatment outcomes for adolescent girls and young women living with HIV in resource-limited settings by evaluating the impact of a novel long-acting HIV treatment. Findings from this study will have important implications for HIV care and treatment approaches and guidelines globally. This research has the potential to make important contributions towards addressing some of the key public health problems in sub-Saharan Africa, including attainment of the UNAIDS 90-90-90 targets; prevention of mother to child transmission of HIV; and maternal morbidity and mortality.

PI_NAMEs: PATEL, RENA CHIMAN (contact)

PROGRAM_OFFICER_NAME: CHIOU, CHEN-CHIA CHRISTINE C

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;Age;Anti-Retroviral Agents;antiretroviral therapy;arm;Behavioral;Caring;Clinic;Clinical;cohort;Contraceptive Agents;Contraceptive methods;Data;Development;Drug Interactions;Drug Kinetics;effectiveness outcome;effectiveness-implementation randomized trial;effectiveness/implementation design;effectiveness/implementation trial;Etonogestrel;Evaluation;Face;Female Adolescents;Focus Groups;Formulation;Fostering;Goals;Guidelines;Health;Health Benefit;Health system;HIV;hormonal contraception;Hybrids;Implant;implementation outcomes;implementation trial;improved;Individual;individualized medicine;Infusion procedures;Injectable;interest;Intervention;Interview;Investigation;Investments;Kenya;Learning;Levonorgestrel;maternal morbidity;Maternal Mortality;Medroxyprogesterone 17-Acetate;Methods;Mother-to-child HIV transmission;novel;open label;Oral;Participant;Patient Compliance;Patients;Pharmaceutical Preparations;pharmacologic;Plasma;Policy Maker;preference;Pregnancy;pregnancy prevention;Prevention;primary outcome;Provider;Public Health;Randomized;Readiness;Regimen;Research;Resource-limited setting;Resources;Sampling;Sentinel;social stigma;standard of care;Structure;supply chain;Surveys;Thinking;treatment arm;Treatment outcome;treatment planning;treatment program;unintended pregnancy;uptake;Viral;Visit;Work;young woman

PROJECT_TITLE: Co-benefits of co-delivery of long-acting antiretrovirals and contraceptives

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Suicide

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE A first episode of psychosis is a leading cause of disability in young adults, with high risk of suicide and all cause mortality. A substantial part of the burden and cost relates to poor functional outcomes, and the inability to determine the right antipsychotic treatment during the earliest phases of psychotic illness, particularly for those who might need clozapine, a medication that is already known to work best for those who do not respond to conventional antipsychotics. In patients with a first episode of psychosis, the present study aims to determine whether the use of biomarker guided treatment decisions leads to better outcomes and equivalent side effects in people prescribed clozapine compared to conventional antipsychotics, including changes in brain function.

PI_NAMEs: MALHOTRA, ANIL K (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acceleration;acute care;Adherence;Adolescence;Age;aged;Agranulocytosis;Antipsychotic Agents;aripiprazole;Biological Markers;blind;Brain;Brain scan;Caring;Clinical;Clozapine;cohort;Complex;Controlled Study;Corpus striatum structure;cost;Country;critical developmental period;critical period;Data;Decision Making;Dedications;Development;disability;dissemination strategy;Dose;early psychosis;Education;efficacy evaluation;efficacy trial;Elements;emerging adult;Employment;expectation;experience;Failure;Family;Family member;Feeling suicidal;first episode psychosis;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Future;General Population;genetic testing;genomic locus;Genotype;Goals;high risk;HLA-DQB1;Hospitalization;Hospitals;Image;implementation science;improved;improved outcome;indexing;Individual;inpatient service;Lifelong disability;Lived experience;Magnetic Resonance Imaging;Melanocortin 4 Receptor;mortality;National Institute of Mental Health;Neutropenia;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacogenetics;Phase;Population;Precision therapeutics;predicting response;predictive marker;preservation;primary outcome;Psychiatry;Psychoses;psychotic;Psychotic Disorders;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Receptor Gene;reducing suicide;Research Design;Resistance;responders and non-responders;response;Rest;Risk;risk variant;Risperidone;Schizophrenia;secondary outcome;Services;side effect;specific biomarkers;Subgroup;suicidal morbidity;suicidal risk;support tools;Symptoms;System;Testing;Therapeutic;tool;treatment response;trial comparing;Weight;Weight Gain;Work;young adult;Youth

PROJECT_TITLE: 2/5-Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-S (60)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: MECHANISMS OF EPIDERMAL HOMEOSTASIS  Project Narrative The mechanisms that control normal tissue growth and differentiation are disrupted in many human diseases. Increasing our understanding of the regulators that mediate these mechanisms is designed to provide information to advance human health for skin and other tissues. 1

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adhesions;Affinity Chromatography;AP-2 Family Transcription Factor;aspartylglutamate;Automobile Driving;Binding;Blood;blood glucose regulation;Calcium;caspase 14;cell type;Cells;Chemistry;claudin-1 protein;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;contextual factors;Coupled;Cues;DDX1 gene;design;Differentiated Gene;dimer;Dimerization;Dissociation;DNA Binding;DNA Sequence;DNA-Binding Proteins;Epidermis;Flow Cytometry;Fluorescent in Situ Hybridization;Funding;Gene Expression Regulation;gene induction;Genes;Genetic Transcription;Genomics;Glucose;Glucose Transporter;glutamylalanine;Growth;Health;helicase;Homeostasis;Homo;Homodimerization;Human;human disease;Individual;insight;keratinocyte differentiation;Knock-out;Mass Spectrum Analysis;Mediating;member;Messenger RNA;Metabolism;Modeling;monomer;morphogens;Neoplasms;Normal tissue morphology;novel;Nuclear;nucleic acid binding protein;Physiological;Production;Proteins;Psoriasis;Regulation;Regulator Genes;Ribosomal RNA;RNA;RNA Binding;RNA Helicase;RNA Splicing;RNA-Binding Proteins;Role;screening;Second Messenger Systems;single-cell RNA sequencing;Skin;Skin Cancer;skin disorder;Specificity;TFAP2A gene;Tissue Differentiation;Tissues;transcription factor;whole genome

PROJECT_TITLE: Mechanisms of Epidermal Homeostasis and Early Neoplasia

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]