NIH_SPENDING_CATS: Chronic Pain;Eye Disease and Disorders of Vision;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Cornea nerves can be damaged by trauma, surgery, infection or diabetes. In this proposal, we will investigate the regenerative potential and functional consequences of adding extracellular vesicles derived from mesenchymal stem cells to damaged corneal nerves. We expect to elucidate basic mechanisms that may lead to new clinical therapies for pathologies that affect the corneal nerves.

PI_NAMEs: DJALILIAN, ALI R (contact);ROSENBLATT, MARK I

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Affect;afferent nerve;Anatomy;arm;Behavior;Benzalkonium Chloride;Biological Assay;Blindness;Blinking;Bone Marrow;bone marrow mesenchymal stem cell;Calcium;cell injury;Cells;Chemical Injury;Chemicals;chronic pain;Clinical;clinically relevant;combinatorial;confocal imaging;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal regeneration;corneal repair;corneal surgery;Coupled;Data;Debridement;Defect;density;Detection;Diabetes Mellitus;Disease;Dry Eye Syndromes;Dryness;Electrophysiology (science);enhancing factor;Epithelium;Esthesia;exosome;extracellular vesicles;Eye;Filament;Functional Regeneration;Growth;Growth Factor;healing;Health;Homeostasis;In Vitro;in vivo;Infection;Injury;injury and repair;Ion Channel;Keratopathy;Light;Lipids;Mass Spectrum Analysis;Mechanics;Mediating;melting;Mesenchymal Stem Cells;Messenger RNA;Methods;MicroRNAs;Modality;Modeling;Molecular;Morphology;Multiple Wounds;Mus;Natural regeneration;Nerve;Nerve Growth Factors;nerve injury;Nerve Regeneration;nerve repair;nerve supply;Neurons;Neuropathy;neurotrophic factor;next generation;Nociceptive Stimulus;novel therapeutic intervention;novel therapeutics;Numbness;Operative Surgical Procedures;Pain;Pathology;Patients;Pattern;Perforation;Piezo 2 ion channel;Process;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Rattus;receptor;Recovery;regeneration function;regeneration potential;regenerative;repaired;Reporter Genes;Resolution;response;restoration;Rodent;Role;sensor;Sensory;Signal Pathway;Site;Source;Sprague-Dawley Rats;Stains;Stimulus;Structure of trigeminal ganglion;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapy outcome;Time;Tissues;transcriptome sequencing;Transgenic Organisms;translational model;Trauma;TRPV1 gene;Tubulin;wound healing

PROJECT_TITLE: Cell-derived therapies for corneal nerve repair: Structural and functional mechanisms

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Despite aggressive treatment to lower lipids and blood pressure, a substantial burden of residual atherosclerotic cardiovascular disease (ASCVD) risk remains. Currently, we have limited knowledge of (1) the underlying mechanisms, (2) risk prediction, and (3) novel treatments for residual ASCVD. We propose to integrate genetic and clinical data to elucidate the mechanisms underlying residual ASCVD risk, identify patients at high risk (additionally accounting for environmental and social factors), and facilitate repurposing of drugs for reducing residual risk.

PI_NAMEs: FENG, QIPING ;WEI, WEI-QI  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Accounting;aggressive therapy;All of Us Research Program;Anti-Hypertensive Agents;Atherosclerosis;atherosclerosis risk;biobank;Biology;Blood Pressure;candidate identification;cardiovascular disorder prevention;cardiovascular disorder risk;Cause of Death;Cessation of life;Clinical;Clinical Data;clinical practice;clinical predictive model;clinical predictors;clinical risk;cohort;conventional therapy;Coronary heart disease;Data;Data Set;Databases;deep learning;Disease;disorder risk;drug candidate;drug repurposing;Drug user;effective therapy;Electronic Health Record;Electronic Medical Records and Genomics Network;Employment Status;Environmental Risk Factor;Equation;Event;experience;explainable artificial intelligence;follow-up;Genes;Genetic;genetic information;genetic predictors;genetic risk factor;Genetic study;genome wide association study;Genomics;heart disease risk;Hematopoiesis;high risk;improved;Inflammation;Informatics;inhibitor;insight;Insurance;Insurance Coverage;Knowledge;LDL Cholesterol Lipoproteins;Life Style;Lipids;Machine Learning;machine learning algorithm;machine learning method;Medical;Medicare;Mendelian randomization;Modeling;Myocardial Infarction;Neighborhoods;novel;novel therapeutics;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;polygenic risk score;prediction algorithm;predictive modeling;Prevention;programs;Residual state;response;Risk;Risk Factors;risk prediction;risk prediction model;Smoking;social;social factors;social health determinants;Stroke;targeted treatment;Techniques;Testing;transcriptome;Variant;virtual;Work

PROJECT_TITLE: Targeting Residual ASCVD Risk by Integrating Genetics and Clinical Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: HADLEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative Only older mosquitoes are competent to transmit pathogens to humans. This project is aimed to develop a rapid, accurate, and robust approach to determine the age of mosquitoes in the field which is critically needed to assess health risks associated with vector-borne diseases. Having the ability to detect vector age in the field would also enable rapid assessment of control strategies, especially those designed to manage or minimize insecticide resistance development.

PI_NAMEs: HE, LILI  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adoption;Aedes;Age;age related;Anti-viral Therapy;Area;artificial neural network;Binding;Biochemistry;Biology;Characteristics;chikungunya;Chikungunya virus;Chronology;combat;cost;cost effective;Culicidae;Data;data sharing;Dengue;Dengue Virus;design;Development;disorder control;Epidemiology;epidemiology study;Evaluation;Food;Goals;Health;health assessment;Human;Incubated;Infection;innovation;Insecticide Resistance;Intervention;Lead;learning strategy;life span;machine learning model;Malaria;Methods;model development;Modernization;Molecular;Monitor;mosquito-borne pathogen;multi-task learning;nanoparticle;Nanotechnology;Neural Network Simulation;Neurons;novel strategies;Parasitic infection;pathogen;Procedures;Protocols documentation;Public Health;Raman Spectrum Analysis;Research;Resistance development;Risk;Risk Assessment;Scientist;Silver;Spectrum Analysis;Surface;System;Techniques;Temperature;Time;tool;transmission process;vaccine access;vector;vector control;vector-borne infection;Vector-transmitted infectious disease;Water;Work;ZIKA;Zika Virus

PROJECT_TITLE: A novel approach of age-grading of mosquitoes using SERS and machine learning models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (02)]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Research Narrative We propose to develop innovative generative AI approaches, with thorough and rigorous evaluation and validation in laboratories, to advance retrosynthesis for small molecules. Successful completion of this project will enable diverse and high-quality synthetic reaction libraries for any given drug-like molecule, which will be highly significant to accelerating drug development (e.g., lead generation). Successful application of the new methodology is ultimately expected to facilitate rapid retrosynthetic analysis of newly discovered or complex molecules as well as those with limited availability, enabling chemical synthesis for subsequent biological evaluations.

PI_NAMEs: FUCHS, JAMES R;NING, XIA  (contact);SUN, HUAN

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TITLE: Generative AI for retrosynthesis libraries

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative  Coronary heart disease accounts for almost half of all cardiovascular disease-related deaths in the US and many instances are due to heart attacks. While scar tissue (fibrosis) is a necessary step in replacing lost heart cells and recovering from a heart attack, too much can cause long-term structural changes to the heart. This project seeks to determine how a specific protein in a critical population of heart cells (cardiac fibroblasts) regulates the organ-level response to a heart attack.

PI_NAMEs: HUND, THOMAS JEFFREY (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Affect;American;Anterior;Arrhythmia;Arteries;betaIV spectrin;Biochemical;Biology;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell Communication;Cell membrane;Cell Nucleus;cell type;Cells;Cessation of life;Cicatrix;Communication;Coronary heart disease;cytokine;Cytoskeletal Proteins;Cytoskeleton;Data;disability;Distal;Ensure;Equilibrium;Event;Exhibits;exosome;experience;extracellular vesicles;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;gene function;Generations;Genes;Genetic;Genetic Transcription;healing;Heart;heart cell;heart function;Human;imaging approach;Immune;improved;In Vitro;in vivo;Infarction;injured;Injury;insight;intercellular communication;ischemic injury;Knock-in;Knockout Mice;Left;Link;link protein;Lipids;Membrane;Messenger RNA;migration;Molecular;mouse model;Mus;Muscle Cells;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Nature;novel;Organ;Outcome;Paracrine Communication;Pathologic;Pathway interactions;Patients;Phase;Phenotype;Phosphorylation;Play;Population;preservation;Prevention;Process;Production;programs;Proliferating;Protein Isoforms;Proteins;Recurrence;Regulation;repaired;response;response to injury;Risk;Role;Rupture;Sentinel;Signal Transduction;Signaling Molecule;spatiotemporal;Spectrin;Stat3 protein;Stimulus;Stress;stressor;targeted delivery;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;transcription factor;Transcriptional Activation;Transducers;Translating;Work;wound healing

PROJECT_TITLE: Novel role for the spectrin cytoskeleton in regulation of cardiac fibroblast activity, long-range communication and injury-induced fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Glutamate is a neurotransmitter in the brain that mediates cognition, memory, and learning; specialized proteins, called glutamate transporters, regulate the amount and movements of glutamate in the brain in processes controlled by ions. This proposal aims to understand how these transporters evolved to perform their essential functions and how they interact with ions in health and disease.

PI_NAMEs: BOUDKER, OLGA  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Affect;Allosteric Regulation;Amino Acid Transporter;Anions;Applications Grants;Architecture;Aspartate;Binding;Binding Sites;Biochemical;biochemical tools;Bioinformatics;Biological Assay;biophysical tools;Biophysics;Brain;Cell membrane;Characteristics;Chloride Channels;Chlorides;Cognition;Comparative Study;Coupled;Coupling;Cryoelectron Microscopy;Diffuse;Disease;Elevator;Engineering;Ensure;Environmental Risk Factor;Episodic ataxia;Evolution;excitatory amino acid transporter 3;Excitatory Amino Acids;excitotoxicity;extracellular;Family;fascinate;Fluorescence Microscopy;Foundations;Glutamate Transporter;Glutamates;Glutamine;Health;Homeostasis;Homologous Gene;Human;innovation;Ion Cotransport;Ions;Knowledge;Learning;Link;Mediating;Membrane;Membrane Transport Proteins;Memory;Methods;Molecular Conformation;Movement;Mutagenesis;Mutation;Nervous System Disorder;neuron loss;neuronal excitability;neuronal survival;Neurons;neurotransmission;neurotransmitter uptake;Neurotransmitters;novel;pain signal;particle;Pathogenicity;Pathologic;Pathology;Play;Probability;Process;Property;Protein Dynamics;Protein Isoforms;Proteins;Protons;reconstitution;reconstruction;Regulation;Resolution;response;Retina;Role;single molecule;single-molecule FRET;Site;structural biology;Structure;Synaptic Cleft;Synaptic Vesicles;Testing;transmission process;uptake;Vesicle;Work

PROJECT_TITLE: Ion coupling, permeation, and regulation in glutamate transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NORMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative Gene cargo delivery systems remain the major challenges to advance cell-based and patient-specific therapies. The goal of the proposed study is to develop an in vitro non-viral intracellular delivery approach for effective gene engineering by combining gas vesicles, protein shells containing gas in the core, and Cas9- ribonucleoprotein (RNP) to form protein clouds as delivery cargo, controlled by ultrasound excitation for safe and efficient manipulation of target cells. The proposed approach has the potential to provide advanced genetic modifications that are required to treat advanced diseases such as solid tumor immunotherapy and neurodegenerative diseases.

PI_NAMEs: YOON, SANGPIL  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acoustics;Address;advanced disease;Area;Bacteria;Behavior Control;Binding;Biological Assay;biomaterial compatibility;Biotinylation;Blood - brain barrier anatomy;cell killing;Cell Line;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Chimeric Proteins;Clinic;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Contrast Media;cost;design;Development;Diagnosis;Disease;disease diagnosis;effective therapy;Encapsulated;Engineered Gene;engineered T cells;Engineering;Ensure;Frequencies;Future;gas vesicle protein;Gases;gene editing technology;Gene Expression;gene therapy;Genes;Genetic;genome editing;Goals;Human body;human disease;Image;improved;In Situ;In Vitro;in vivo;individualized medicine;innovation;Intracellular Membranes;Investigation;Laboratories;lipid nanoparticle;macromolecule;Mammalian Cell;manufacturability;manufacture;Measures;Mediating;Medical;Methods;Microbubbles;Modification;monomer;Mus;Mutation;nanoGold;nanoparticle;Nanostructures;neoplasm immunotherapy;Neurodegenerative Disorders;next generation;novel;nuclease;off-target mutation;Patients;Penetration;Peptides;Permeability;Phenotype;Physiological;Plasma Cells;plasmid DNA;process improvement;Production;protein expression;Proteins;Recovery;Research;Resolution;Ribonucleoproteins;Safety;scale up;side effect;Site;Solid Neoplasm;Sonication;spatiotemporal;Specificity;Streptavidin;System;T-Lymphocyte;targeted treatment;Techniques;Testing;theranostics;Therapeutic;Time;tool;TP53 gene;Transfection;translational applications;treatment strategy;tumor;ultra high resolution;Ultrasonic Therapy;Ultrasonic Transducer;Ultrasonography;ultrasound;Vesicle;Viral;Virus

PROJECT_TITLE: Development of protein-based nanostructures activated by ultrasound

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative This project aims to identify early developmental, biomedical, and molecular indicators of risk for severe or profound intellectual disability in young children with Down syndrome (DS). Young children with DS will be assessed at three time points and cognitive outcomes will be analyzed in relation to behavioral, biomedical, and molecular risk factors. Results of this work will promote greater inclusivity in DS research and may facilitate innovations in both biomedical and behavioral intervention.

PI_NAMEs: BAUMER, NICOLE ;ESPINOSA, JOAQUIN M.;FIDLER, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Affect;Area;autism spectrum disorder;Behavior;Behavior Therapy;Behavioral;biobehavior;Biological;Biological Markers;biomarker identification;biosignature;Blood specimen;Catabolism;Child;Cognition;Cognitive;cognitive development;cognitive skill;Communication;Communities;Data;Data Collection;Databases;Development;Dimensions;Disability outcome;Down's Syndrome;Early identification;Evaluation;Exclusion;Foundations;Future;Genes;Goals;Growth;Heterogeneity;IGF1 gene;Immune;Impaired cognition;inclusion criteria;Individual;Inflammatory;inflammatory marker;innovation;Intellectual functioning disability;Interferons;Intervention;Investigation;Knowledge;Kynurenine;Leukocytes;Linguistics;Link;Literature;maladaptive behavior;Metabolism;metabolome;Modeling;Molecular;Motor;multiple omics;Nature;Nerve Degeneration;neurobiological mechanism;neuroinflammation;neuropathology;neurotoxic;novel;novel therapeutic intervention;Outcome;overexpression;Pathway interactions;Phenotype;Plasma;Population;Probability;Process;Proteome;rate of change;Recording of previous events;recruit;Research;Research Project Grants;Risk;Risk Factors;Sensory;Severities;sex;Signal Pathway;skill acquisition;skills;social communication;sociodemographics;Somatotropin;Temperament;Testing;Time;transcriptome;Tryptophan;United States National Institutes of Health;virtual;Visit;Work

PROJECT_TITLE: Risk for Severe/Profound Intellectual Disability in Down Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Chagas disease is the result of infection with the parasite Trypanosoma cruzi and is characterized by compromised heart function in humans and in the many other host species that this parasite naturally infects, including dogs in the continental United States. This project will use a setting of high intensity transmission in dogs in south Texas to investigate questions of importance to the management of T. cruzi infection in humans, related in particular to the benefit of early and successful resolution of the infection using drug therapy, to prevention of the development of disease. Completion of this work will provide guidance for the how to best reduce the impact of T. cruzi on human and animal populations.

PI_NAMEs: HAMER, SARAH ANNE;TARLETON, RICK L (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;acute infection;Address;Aftercare;Animals;Antibody titer measurement;B-Lymphocytes;Benznidazole;Biology;Blood;Blood specimen;Canis familiaris;Cardiac;Cessation of life;Chagas Disease;Chronic;chronic infection;Chronic Phase;Clinical;clinical development;Collaborations;curative treatments;Data;design;Development;Diagnostic;Disease;Disease Progression;disorder prevention;Dog Diseases;Dose;Drug usage;Early Diagnosis;Early treatment;Echocardiography;effective therapy;Electrocardiogram;Enrollment;Environment;Ethics;experience;Experimental Models;exposed human population;Exposure to;Frequencies;Future;Goals;Hand;heart damage;Heart Diseases;heart function;Human;human model;Immune;Immune response;Immunity;Immunologics;improved;Incidence;Individual;Infection;infection management;infection rate;infection risk;Insect Vectors;Intervention;Knowledge;Maintenance;Mammals;Monitor;Morbidity - disease rate;Muscle;Myocardial dysfunction;Nature;Needs Assessment;Outcome;Parasites;Parasitology;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Population;Positioning Attribute;prevent;Prevention;Primary Infection;Prophylactic treatment;Protocols documentation;Recording of previous events;Research;Research Personnel;Resistance;Resistance to infection;Resolution;response;Risk;Scientist;screening;Seasons;Serology;serosurveillance;Serum;skills;South Texas;success;Symptoms;T-Lymphocyte;Texas;Time;Tissues;tool;transmission process;treatment comparison;treatment group;Treatment outcome;Treatment Protocols;treatment response;Troponin;Trypanosoma cruzi;Uncertainty;unethical;United States;vector;vector control;Work;Zoonoses

PROJECT_TITLE: Treatment outcome requirements for disease prevention in Chagas disease

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Title of Project: “Solving longstanding mysteries in plasma triglyceride metabolism” Genetic variation that impairs the efficiency of intravascular triglyceride hydrolysis by lipoprotein lipase (LPL) increases the risk of coronary heart disease, yet the functions of key regulators of plasma triglyceride metabolism have remained enigmatic. We will use advanced biophysical methods, advanced microscopy, and physiologic studies in mice to elucidate the functions of two apolipoproteins that regulate LPL activity, and we will explore the turnover and trafficking of LPL in capillaries. Our work will provide fresh insights into the molecular physiology of plasma triglyceride metabolism and new strategies for treating cardiometabolic diseases.

PI_NAMEs: FONG, LOREN GI (contact);PLOUG, MICHAEL

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;ANGPTL3 gene;ANGPTL4 gene;Antibodies;APOA5 gene;apolipoprotein C-II;Apolipoproteins;Autoantibodies;Binding;Biology;biophysical techniques;Biophysics;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;Cardiac Myocytes;Cardiometabolic Disease;Cells;Chest;Collaborations;Complex;Coronary heart disease;Deuterium;Dietary Fats;empowerment;Endothelial Cells;Event;experience;experimental study;Fasting;Fatty Acids;feeding;Genetic Variation;Goals;Grant;Half-Life;Heart;heart disease risk;human disease;Hydrogen;Hydrolase;Hydrolysis;Image;Impairment;In Vitro;in vivo;insight;interest;International;interstitial;Journals;Kinetics;Laboratories;lipid metabolism;Lipolysis;lipoprotein lipase;Lipoproteins;Location;Mammals;Mass Spectrum Analysis;Medicine;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;monomer;mouse model;Movement;Mus;Mutation;Paper;Peripheral;Physiological;Physiology;Plasma;polyclonal antibody;Positioning Attribute;preservation;Principal Investigator;Production;Proteins;Publishing;Reagent;Recombinant Proteins;Recombinants;Regulation;Risk;Role;Scanning;skills;Stable Isotope Labeling;Structure;success;Surface Plasmon Resonance;Testing;Textbooks;Tissues;tool;trafficking;Triglyceride Metabolism;Triglycerides;Vertebrates;Work;X-Ray Crystallography

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Dietary Supplements;Hematology;Infectious Diseases;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sepsis

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed project is important for public health because our well characterized sepsis animal model will provide the mechanistic basis to the development of new targeted nutritional formulations for critically ill patients that enhance rehabilitation through restoring muscle health and physical activity.

PI_NAMEs: DEUTZ, NICOLAAS E (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acceleration;Acute;Amino Acids;Animal Model;Antibiotics;arm;Attenuated;Autophagocytosis;Behavior;beta-hydroxyisovaleric acid;Biopsy;Catabolism;Catheterization;Clinical;clinical application;clinically relevant;cognitive rehabilitation;combat;Complication;cost effective;Critical Illness;Death Rate;design;Development;Dietary Intervention;Disease;Double-Blind Method;effectiveness evaluation;Essential Amino Acids;Evaluation;Family suidae;Fatigue;Formulation;Foundations;Functional disorder;functional outcomes;Glutathione;Goals;Health;Hour;Human;Human Characteristics;IL6 gene;Impairment;improved;Infection;innovation;insight;Interleukin-10;Kinetics;Knowledge;Life;Liver;loss of function;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Methodology;Modeling;Molecular;Monitor;Morbidity - disease rate;Muscle;Muscle Fatigue;muscle form;Muscle function;Muscle Proteins;Muscle rehabilitation;muscle strength;Muscle Weakness;Muscular Atrophy;Nature;novel;novel strategies;Nutrient;nutrition;Nutritional;nutritional approach;nutritional supplementation;Nutritional Support;Organ;Outcome;Patients;Physical activity;Placebos;Plasma;porcine model;primary endpoint;Production;Protein Biosynthesis;protein metabolism;Proteins;proteostasis;Pseudomonas aeruginosa;Public Health;Randomized;Recovery;Rehabilitation therapy;Research;response;Sampling;sensor;Sepsis;Signal Pathway;Skeletal Muscle;Supplementation;Technology;Testing;Therapeutic;Tissues;TNF gene;Tracer;translation to humans;translational model;Translations;Transmembrane Transport;Ubiquitin;wasting

PROJECT_TITLE: Targeted nutritional approach to restore muscle health and physical activity after sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it utilizes a mechanistic understanding of the progression of chronic ischemic heart failure in cardiomyocytes to restore function and improve cardiac function. The study will provide critical preclinical data in a large animal model on the therapeutic efficacy of a first-in-class gene therapy for dilated ischemic cardiomyopathy. Thus, the proposed research is relevant to the NIH’s mission to enhance health, legthen life, and reduce illness and disability.

PI_NAMEs: DOSDALL, DEREK J;SHAW, ROBIN M (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adrenergic Agents;Animal Model;Animals;Arrhythmia;Biological Markers;Biology;Calcium;canine model;Canis familiaris;Cardiac;Cardiac Myocytes;Chronic;Clinical;Coronary Occlusions;Dangerousness;Data;Dependovirus;Development;Diastolic heart failure;Diffusion;Dilated Cardiomyopathy;disability;Echocardiography;Effectiveness;effectiveness evaluation;EFRAC;Electrocardiogram;Event;extracellular;falls;functional restoration;Gene Dosage;gene therapy;Goals;Health;Heart;Heart failure;heart function;hemodynamics;Human;Impairment;improved;in vivo;Incidence;Ions;Ischemia;ischemic cardiomyopathy;Laboratory Finding;Left Ventricular Function;Life;Maps;Medicine;Membrane;Membrane Microdomains;Mission;Modeling;Monitor;mortality;Mus;Muscle;Muscle Cells;Myocardial Ischemia;Myocardium;novel;Optics;Pathologic;Pathway interactions;Patients;pre-clinical;Predisposition;pro-brain natriuretic peptide (1-76);Public Health;Recovery of Function;recruit;Relaxation;Research;reuptake;Rodent Model;Role;Sarcoplasmic Reticulum;Satellite Viruses;SERCA2a;Serum;Stress;Surface;Syndrome;Systolic heart failure;Telemetry;Testing;Therapeutic;Translating;Treatment Efficacy;United States;United States National Institutes of Health;validation studies;Ventricular Arrhythmia;voltage

PROJECT_TITLE: Novel Gene Therapy For Chronic Ischemic Heart Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: OVERALL: PROJECT NARRATIVE Our long-term goal is to achieve comprehensive predictive models that can guide precision medicine and synthetic biology. Toward this goal, we will make models understandable, reproducible, credible and reusable by (1) developing tool for reproducibly and credibly building, simulating, and analyzing models; (2) assembling these tools into a user friendly workflow; (3) providing the community services for annotating, simulating, and validating models; (4) promoting the importance of reproducibility; and (5) training researchers to conduct modeling reproducibility. These efforts will enhance the reproducibility of modeling and, in turn, enable comprehensive models.

PI_NAMEs: MORARU, ION I.;SAURO, HERBERT M. (contact)

PROGRAM_OFFICER_NAME: PENG, GRACE

PROJECT_TITLE: Center for Reproducible Systems for Biomedical Modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-C (O1)]


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: SAURO, HERBERT M. (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Agreement;Area;Attention;Automation;Biological;Biomedical Research;Black Box;Caring;Cell model;Charge;Clinic;Code;Collaborations;Communities;Computer Models;Computer Simulation;Computer software;COVID-19;COVID-19 pandemic;Data;digital twin;Documentation;Equilibrium;Event;Evolution;flexibility;Fostering;Future;Goals;Grant;Healthcare;improved;Industry;Infrastructure;Laws;Learning;model building;Modeling;models and simulation;neurophysiology;Pharmacologic Substance;Phase;Policy Maker;Process;Programming Languages;Publishing;Pythons;Recommendation;Reporting;repository;Reproducibility;Research Personnel;Series;Services;software development;Software Engineering;Source Code;Specific qualifier value;success;System;Systems Biology;Techniques;Technology;technology research and development;Testing;Time;tool;Trust;trustworthiness;Uncertainty;user-friendly;Validation;Work

PROJECT_TITLE: TRD&1: Model Management and Credibility Infrastructure


PI_NAMEs: GENNARI, JOHN H. (contact)

PROJECT_TERMS: Adoption;Collaborations;Collection;Communities;Computer software;cost;Databases;Development;Elements;Evolution;Experimental Models;experimental study;Feedback;Goals;improved;invention;Learning;Mathematics;Methods;Modeling;models and simulation;Ontology;Publishing;Recommendation;Recording of previous events;Reporting;repository;Reproducibility;Research Personnel;Resources;Semantics;software development;Software Tools;support tools;System;Technology;technology development;technology research and development;Time;tool;Work

PROJECT_TITLE: TR&D2: Ontology and software tools describing reproducibility, credibility, and biosimulation


PI_NAMEs: MORARU, ION I. (contact)

PROJECT_TERMS: Address;Algorithms;Automobile Driving;Biological;Biological Models;biological systems;Biology;Cell model;Cells;cloud based;Code;Communities;Complex;Computer Models;Computer software;Data;Drops;Ecosystem;Elements;Environment;Evaluation;Exercise;flexibility;Foundations;Hybrids;Individual;Internet;Methods;model building;model design;Modeling;multi-scale modeling;multimodality;next generation;novel;Process;Property;Protocols documentation;Publishing;Pythons;Registries;Reporting;repository;Reproducibility;Scientist;Series;Services;simulation;software development;Software Engineering;Software Tools;Specific qualifier value;Standardization;System;technology research and development;Testing;Time;Tissue Model;tool;Update;Validation;web portal;Work

PROJECT_TITLE: TR&D3: Standards and Tools for Simulator Composition and Credibility portal


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PROJECT_TITLE: Technology Training and Dissemination


NIH_SPENDING_CATS: Cancer

ORG_CITY: BUFFALO

ORG_NAME: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST

PHR: PROJECT NARRATIVE Our study focuses on a multi-component switching mechanism that changes the activity of Grp94 from a normal folding chaperone to a disease specific variant that helps cancer cells survive. We introduce a new method of separately studying the individual elements of this switching mechanism, and use this technology to dissect how each component alters the function of the chaperone. Our overarching goals are to discover how this switch changes Grp94 and to use this knowledge to distinguish between the pathologic and normal forms of Grp94 so that the first can be targeted for treatment while second is spared.

PI_NAMEs: GEWIRTH, DANIEL T (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: ATP phosphohydrolase;Binding;Biochemical;biochemical tools;Biological Assay;biomarker identification;cancer cell;Cancer cell line;Cell secretion;Cell surface;Cell Survival;Cells;Cellular Stress;Chronic Disease;Client;Complex;Cryoelectron Microscopy;Data;Development;dimer;Disease;Drug Design;Elements;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Environment;ERBB2 gene;Familial Hypercholesterolemia;Foundations;functional status;Glycoproteins;glycosylation;Goals;Heat-Shock Proteins 90;In Vitro;in vivo;Individual;insight;Knowledge;Ligand Binding;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;member;Membrane;Methods;migration;Minor;Molecular;Molecular Chaperones;Monitor;Multiple Myeloma;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;novel therapeutics;Null Lymphocytes;overexpression;Pathogenicity;Pathologic;Pathology;Pattern;Polysaccharides;Positioning Attribute;Post-Translational Protein Processing;Production;Protein Biosynthesis;protein folding;Protein Secretion;Proteins;proteostasis;Receptor Protein-Tyrosine Kinases;Regulation;Research;response;Role;Sepsis;Site;Stress;Structural defect;Structure;System;targeted treatment;Technology;Testing;Therapeutic Intervention;therapeutic target;Tissues;Variant;Visualization

PROJECT_TITLE: N-glycosylation as a regulator of Grp94 Function and Activity

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Schizophrenia represents a major public-health problem worldwide. In this proposal, we aim to combine fMRI, neurocognitive, and clinical data across multiple large-scale datasets to provide an explanatory theoretical model for understanding neural ensemble alterations in patients with schizophrenia and their relationship to cognitive deficits. In doing so, we hope to elucidate their biological mechanisms and contribute to the development of novel therapeutics for cognitive deficits and brain-based biomarkers for treatment selection and target engagement.

PI_NAMEs: WENGLER, KENNETH  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Affect;area striata;Attention;Auditory;Biological;Biological Markers;biophysical model;Bipolar Disorder;Brain;brain based;Calcium;Characteristics;Chronic;Clinical Data;Cognition;cognitive ability;Cognitive deficits;cognitive performance;cognitive task;comparison control;Complement;connectome;Data;Development;Disease;Disparate;early psychosis;effective therapy;Equilibrium;Exhibits;experimental study;First Degree Relative;Foundations;Functional Magnetic Resonance Imaging;Genetic;genetic variant;Goals;Human;human data;imaging study;Impairment;improved;indexing;Individual;Investigation;Ketamine;large scale data;Measures;Methods;Modality;Modeling;models and simulation;Motivation;mouse model;Mus;National Institute of Mental Health;neural;Neurobehavioral Manifestations;Neurocognitive;neurocognitive test;neuroimaging;Neurons;neurophysiology;Neurosciences;novel;novel strategies;novel therapeutics;Patients;Penetrance;pharmacologic;Phenotype;Photic Stimulation;Population;pre-clinical;preclinical study;predictive modeling;Prefrontal Cortex;Property;Psychoses;Public Health;Quality of life;Research;Rest;Risk;Role;Sampling;Schizophrenia;Selection for Treatments;Seminal;Sensory;sensory cortex;Strategic Planning;Testing;Theoretical model;theories;therapy development;Translating;Translations;V1 neuron;Validation;Visual;Work;young adult

PROJECT_TITLE: Biophysical modeling as a translational bridge for understanding neural ensemble alterations in schizophrenia.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Neurosciences;Pain Research;Physical Activity

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Peripheral arterial disease (PAD) is a progressive atherosclerotic disorder that impacts >200 million people worldwide. Physical activity is greatly reduced in these patients by exercise-associated pain, thus diminishing functional capacity and quality of life. We seek to elucidate the neuronal mechanisms that produce exercise- associated pain and determine the potential benefits of Nrf2 upregulation in muscle afferent neurons.

PI_NAMEs: WANG, HANJUN  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Ablation;Activities of Daily Living;Address;Affect;Afferent Neurons;Agonist;Animal Disease Models;Animal Model;Animals;Anti-Inflammatory Agents;Antioxidants;Arterial Fatty Streak;Blood flow;Blood Pressure;Cardiovascular Physiology;Chronic;claudication;Clinical Research;Curcumin;cytokine;Data;design;Disease;disease model;Encapsulated;Exercise;exercise capacity;Exertion;Generations;Goals;Heart Rate;Hydrogels;improved;indexing;Infiltration;Inflammation;Inflammatory;Intermittent Claudication;Ion Channel;Ischemia;Knock-out;Laboratories;Leg;Limb structure;Macrophage;Mediating;Methods;Micelles;Modeling;Molecular;mouse model;Mus;Muscle;Myopathy;neural;neuroinflammation;neuromechanism;neuronal excitability;Neurons;Nociception;novel;nuclear factor-erythroid 2;overexpression;Oxidative Stress;Oxygen;Pain;pain behavior;Pain in lower limb;pain sensation;pain symptom;Pain Threshold;Patients;Perfusion;Peripheral arterial disease;Persons;Pharmaceutical Preparations;pharmacologic;Physical activity;Pilot Projects;Potassium Channel;protein expression;Proteins;Quality of life;Rattus;receptor;Reflex action;Regulation;Reporter;Resiniferatoxin;response;Rest;Role;Signal Transduction;Skeletal Muscle;Spinal Ganglia;System;Time;Tissues;transcription factor;Transgenic Organisms;TRPV1 gene;United States;Up-Regulation;vasoconstriction;Vasoconstrictor Agents;Walking;Western Blotting

PROJECT_TITLE: Nrf2 and the exaggerated Exercise Pressor Reflex in Peripheral Arterial Disease


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: GAINESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Clinician-scientists play an essential role in the application of new technologies and discoveries to clinical practice. We propose that didactic training and a 2-4 immersion in the laboratory of a successful basic scientist, or the application of basic science to precision/personalized medicine, with expertise in molecular biology will provide a sound foundation for a career as a physician-scientist involved in translational research in inflammation biology, relevant to trauma, sepsis, burns and critical care survivors. The successful trainee will develop expertise in functional genomics, molecular genetics and molecular biology to help translate the current genomic revolution to improved clinical practice, and will be prepared to serve as a national leader in surgical/clinical academics.

PI_NAMEs: EFRON, PHILIP A (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Burn injury;Molecular Biology;Trauma

PROJECT_TITLE: Molecular Biology in Burns and Trauma

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (PD)]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The proposed research is relevant to public health because cohesin-mutant MDS is an aggressive disease with poor outcomes, for which there is no targeted therapy available and the mechanisms of which are not well understood. This project is relevant to the NIH’s mission to gain fundamental knowledge to reduce illness because it will elucidate novel treatment strategies in cohesin-mutant MDS based on understanding of the genetic basis of the disease.

PI_NAMEs: TOTHOVA, ZUZANA  (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;age related;Alleles;Automobile Driving;Binding;Binding Proteins;Biological;Biological Markers;Biology;Cells;Chromatin;Clinical Trials;clinically significant;Clonal Expansion;cohesin;cohesion;Complex;crosslink;CSPG6 gene;Data;Dependence;Development;Disease;disorder risk;DNA Repair;Drug Targeting;Dysmyelopoietic Syndromes;effective therapy;experience;experimental study;Frequencies;Functional disorder;Gene Expression Regulation;Genes;Genetic;Genetic Engineering;Genetic Transcription;Goals;Hematopoiesis;Hematopoietic stem cells;high risk;Human;Immunoprecipitation;Impairment;improved outcome;in vitro Model;in vivo;Ineffective Hematopoiesis;innovation;insight;Knowledge;Laboratories;Mediating;Medical;Mission;Modeling;Molecular;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloproliferative disease;novel;novel strategies;novel therapeutic intervention;Outcome;Output;Patients;progression risk;Proliferating;protein complex;Proteins;Public Health;Research;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Sister Chromatid;Spliceosomes;targeted treatment;Testing;Therapeutic;therapeutic target;Transcriptional Regulation;transcriptomics;treatment response;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: Molecular mechanisms of splicing dependency in cohesin-mutant myelodysplasia

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cardiovascular

PHR: NARRATIVE The purpose of this T35 grant renewal is to provide intensive, short-term (10-week) research training for 20 medical students who will conduct clinical, translational, and basic research projects relevant to the mission of the National Heart, Lung, and Blood Institute. The research will be conducted under the mentorship of faculty members from the Colleges of Medicine and Engineering, who have a proven record of mentoring. The program is designed to attract the most highly qualified University of Florida medical students into careers as physician- scientists in the fields of cardiovascular and pulmonary research.

PI_NAMEs: BERCELI, SCOTT A (contact);MAILE, ROBERT

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Area;Biometry;Cardiovascular system;career;Career Choice;college;design;Educational Curriculum;Elements;Engineering;experience;Exposure to;Faculty;First Independent Research Support and Transition Awards;Florida;Foundations;fundamental research;Future;Goals;Grant;improved;interest;Knowledge;Literature;Lung;Manuscripts;Medical;medical schools;Medical Students;Medicine;member;Mentors;Monitor;Outcome;Pathway interactions;peer;Peer Review;Preparation;programs;Publications;Published Comment;Regulation;Reproducibility;Research;Research Ethics;Research Project Grants;Research Training;responsible research conduct;Scholarship;senior faculty;Series;skills;Students;success;Training;Training Programs;Universities

PROJECT_TITLE: Renewal: Short-Term Training for Medical Students in Cardiovascular and Pulmonary Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-B (O1)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Porphyromonas gingivalis is a periodontal pathogen that colonizes in subgingival plaque and use a specialized secretion system (T9SS) to deliver virulence factors including the gingipain proteases. This project seeks to define the T9SS architecture and mechanistic details of cargo translocation to lay a foundation for development of intervention strategies aimed at blocking T9SS function and disease progression.

PI_NAMEs: HU, BO  (contact);LAMONT, RICHARD J

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TITLE: Structure and Function of Porphyromonas gingivalis Type IX Secretion System

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Neurosciences;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative Breast cancer remains the most common malignancy among women worldwide. Clinical work demonstrates that patients with ‘blunted’ circadian rhythms in circulating glucocorticoids (e.g., cortisol) have worse quality of life and succumb to cancer earlier than those with robust rhythms. This work will identify the mechanism(s) driving this deleterious phenomenon and develop therapeutic approaches to target it, likely conferring benefits to patients with breast cancer.

PI_NAMEs: BORNIGER, JEREMY  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acute;Adrenal Cortex;Adrenal Glands;Anterior Pituitary Gland;anti-cancer;Arousal;Automobile Driving;Breast Cancer Cell;Breast Cancer Model;breast cancer progression;Calcium;cancer immunotherapy;Cancer Patient;candidate identification;carcinogenesis;cell type;Cells;checkpoint inhibition;circadian;circadian pacemaker;Circadian Rhythms;Circulation;Clinical;Colorectal Cancer;Corticosterone;Corticotropin;Corticotropin-Releasing Hormone;CRISPR/Cas technology;Data;data integration;design;designer receptors exclusively activated by designer drugs;Development;Dexamethasone;Disease;Dissection;Distal;Electrophysiology (science);Excitatory Synapse;Exhibits;experience;experimental study;Fatigue;Feedback;Flow Cytometry;Functional disorder;Gene Expression;Genes;Genetic;Glucocorticoids;Growth;Guide RNA;Health;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immunohistochemistry;Immunotherapy;Impairment;improved;improved outcome;in vivo;Injections;Knock-out;Life;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic breast cancer;Molecular;mortality;mouse model;Mus;Natural Killer Cells;Neurons;neuroregulation;novel therapeutic intervention;novel therapeutics;Outcome;Palpable;paraventricular nucleus;Patients;Peripheral;Phase;Phenotype;Physiological Processes;Pituitary Gland;pre-clinical;Process;Production;Proteins;Quality of life;Reporting;response;single-cell RNA sequencing;Slice;Solid Neoplasm;Specific qualifier value;System;Testing;Therapeutic;Time;Tissue Banks;Tissues;tool;trafficking;transcriptome sequencing;Treatment Efficacy;tumor;tumor growth;tumor progression;virtual;Woman;Work

PROJECT_TITLE: Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: AI2Equity: AI Integrating SDOH Data to Advance Health Equity in Cardiovascular Risk Prediction Narrative There is a pressing need to address health disparities in cardiovascular disease (CVD). This study will use machine learning to develop a novel CVD risk prediction model that considers social determinants of health, structural social factors, and clinical factors together, as well as their complex interactions. The model will be designed to be equitable, interpretable, and generalizable across diverse populations.

PI_NAMEs: LIU, FEIFAN  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Acceleration;Address;Algorithms;Architecture;Artificial Intelligence;Artificial Intelligence enhanced;artificial intelligence model;Attention;Benchmarking;Biometry;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Caring;Clinical;clinical decision support;clinical risk;Clinical Trials;Communities;Community Health Networks;compare effectiveness;Complex;Data;deep learning;design;Development;Disparity;Disparity population;disparity reduction;diverse data;empowerment;Equity;Ethics;ethnic minority;evidence based guidelines;explainable artificial intelligence;Foundations;Future;Goals;health data;health disparity;health equity;health equity promotion;health inequalities;Healthcare;Healthcare Systems;heterogenous data;Hospitals;improved;Incidence;innovation;insight;Institution;Intervention;Learning;Machine Learning;marginalized population;Methodology;Minority Groups;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;National Institute on Minority Health and Health Disparities;Natural Language Processing;Neighborhood Health Center;novel;Outcome;Patient Care;patient population;Patients;Performance;Persons;Policies;Population Heterogeneity;predictive tools;Prevalence;preventive intervention;Primary Care;Primary Prevention;Race;racial minority;Research;Resource Allocation;resource guides;responsible artificial intelligence;Risk Factors;risk prediction;risk prediction model;social;social disparities;social factors;social health determinants;social structure;Social support;Social Work;socioeconomics;Solid;structural determinants;System;Techniques;Testing;tool;transfer learning;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: AI2Equity: AI Integrating Social Determinants of Health to Advance Health Equity in Cardiovascular Risk Prediction

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  The human lung, similar to other internal organs, is encapsulated by a thin squamous epithelium called the mesothelium. Aside from knowledge that mesothelial cells produce lubricating fluid to facilitate smooth organ movement in relationship to each other and the body wall, mesothelium function in lung development and injury repair remains poorly understood. In this study, we will use Myelin Regulatory Factor, a transcription factor that is expressed in the mesothelium as an entry point to address the formation of this fundamental cell layer, its role as a signaling center in lung growth, and its crosstalk with other injured cell types in lung repair.

PI_NAMEs: SUN, XIN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Abdominal Cavity;Actins;Address;Adult;AGTR2 gene;Alveolar;Alveolar Cell Type I;alveolar epithelium;Asbestos;Birth;Bleomycin;body cavity;Bypass;cell fate specification;cell injury;Cell Physiology;Cell Shape;cell type;Cells;Characteristics;Chest;Clinical;Code;comparison control;Congenital diaphragmatic hernia;Cytoskeletal Proteins;Data;Death Rate;Development;Disease;Disease Progression;Embryo;Encapsulated;Epithelial Cells;Epithelium;Extracellular Matrix;FGF9 gene;Fibroblasts;Fibrosis;Foundations;Genes;Genetic Transcription;Growth;Growth Factor;Homeostasis;Human;idiopathic pulmonary fibrosis;IGF1 gene;Immune;Injury;injury and repair;Interstitial Lung Diseases;Knowledge;Liquid substance;Lubricants;Lung;lung development;lung injury;lung repair;Mesenchyme;Mesoderm;Mesothelial Cell;Mesothelioma;Mesothelium;migration;Movement;Mus;mutant;Mutation;Myelin;Myofibroblast;Nuclear;Organ;Pathogenesis;Pathway interactions;Patients;Phenotype;Pleura;Pleural;postnatal;Pulmonary Fibrosis;pulmonary hypoplasia;Respiratory Diaphragm;Respiratory distress;Role;Sentinel;Signal Transduction;single-cell RNA sequencing;Site;Slide;Smooth Muscle;Squamous Epithelium;stem cells;synergism;Testing;Thinness;transcription factor;Transitional Cell;Variant

PROJECT_TITLE: MYRF as an Entry Point to Study Mesothelium Function in Lung Development and Injury Repair

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Patient Safety;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Relevance  Immunotherapy in combination with chemotherapy has proven highly effective for TNBC; however, some patients develop severe adverse events, and many may not benefit from treatment. We will investigate auto-antibody response in predicting adverse events and recurrence during and after single agent pembrolizumab therapy. Our split sample discovery and independent validation design using hundreds of samples from an FDA registration trial has the potential to introduce a clinically useful new biomarker that could optimize the use of immune checkpoint therapy in cancer.

PI_NAMEs: PUSZTAI, LAJOS ;QIU, JI  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adjuvant Therapy;Adopted;Adverse effects;Adverse event;anti-PD-1;anti-PD1 antibodies;Antibodies;antibody detection;antibody test;Antigen Targeting;Antigens;arm;Autoantibodies;Autoimmune Diseases;Autoimmunity;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Blinded;cancer cell;cancer diagnosis;Cancer Etiology;cancer invasiveness;cancer recurrence;candidate identification;candidate marker;candidate validation;checkpoint therapy;chemotherapy;Clinical;clinical predictors;Clinical Trials;clinically relevant;cohort;Collaborations;design verification;Detection;Development;efficacy evaluation;efficacy testing;Evaluation;Goals;high risk;Human;immune checkpoint blockade;Immune response;Immune system;immune-related adverse events;Immunosuppression;Immunotherapy;in silico;Individual;insight;Length;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Modeling;Neoadjuvant Therapy;Normal tissue morphology;Nucleic Acids;Organ;Outcome;outcome prediction;participant enrollment;Pathogenicity;Patient Monitoring;Patients;pembrolizumab;Performance;phase III trial;Physicians;Positive Lymph Node;Postoperative Period;Practice Guidelines;Prediction of Response to Therapy;predictive marker;predictive modeling;Predictive Value;prospective;Protein Array;Proteins;Proteome;Randomized;randomized trial;receptor;Recurrence;Research Design;Residual state;response;Risk Estimate;risk/benefit ratio;Role;Safety;Sampling;Scientist;Serious Adverse Event;Serology;Serum;Site;Southwest Oncology Group;success;Symptoms;Technology;Testing;Therapeutic;Therapeutic Intervention;tissue archive;Toxic effect;Treatment Efficacy;triple-negative invasive breast carcinoma;Tumor Immunity;tumor initiation;Validation;Women's mortality

PROJECT_TITLE: Serum biomarkers to predict immune related adverse events and benefit from single agent pembrolizumab therapy in early stage triple negative breast cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Treatment-resistant metastatic castration-resistant prostate cancer (mCRPC) is the deadliest form of prostate cancer, with a dismal median survival of only ~5.5 months. Unfortunately, by the time this deadly form of disease is diagnosed, patients are already progressing on androgen receptor (AR)- directed drugs and prognosis is very poor. We developed a liquid biopsy biomarker, referred to as EnhanceAR-Seq, to more sensitively detect resistance early with the longer-term goal of advancing personalized treatment strategies to improve patient outcomes and survival.

PI_NAMEs: CHAUDHURI, AADEL ;MAHER, CHRISTOPHER A (contact);PACHYNSKI, RUSSELL K.

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: abiraterone;Address;androgen independent prostate cancer;Androgen Receptor;Androgen Therapy;AR gene;Biological Assay;Biological Markers;Biometry;cancer genomics;Cancer Patient;Cancer Personalized Profiling by Deep Sequencing;cancer type;cell free DNA;Cells;Clinic;Clinical;Computational Biology;Data;design;Detection;detection sensitivity;determinants of treatment resistance;Development;Diagnosis;Disease;Disease Progression;Disease Resistance;DNA analysis;DNA methylation profiling;DNA Sequence Alteration;Enhancers;enzalutamide;epigenomics;Evolution;Exposure to;genome wide methylation;genome-wide;genomic locus;Genomics;Goals;human tissue;improved;Lead;liquid biopsy;Malignant neoplasm of prostate;Measures;men;Metastatic Prostate Cancer;Monitor;multiple omics;Neoplasm Circulating Cells;novel;Oncologist;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Plasma;Plasma Cells;Positioning Attribute;predictive marker;Prognosis;prospective;Resistance;Resistance development;Resolution;response;sequencing platform;standard of care;survival outcome;Technology;therapy development;therapy resistant;Time;translational impact;treatment strategy;tumor;Tumor Markers;Tumor Tissue;Upstream Enhancer;Variant;Work

PROJECT_TITLE: Novel ctDNA biomarker for androgen therapy in metastatic prostate cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Prevention

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative The goal is to determine and validate an objective integrated multimodal electrophysiological index to assess the level of visceral pain in patients with irritable bowel syndrome (IBS). We will establish this objective biomarker through non-invasive surface recordings of the autonomic neural activities and building a mathematical prediction model via machine learning algorithms. This biomarker will lead to accelerated development of preventive and therapeutic schemes, especially non-opioid treatments for effective pain management in IBS.

PI_NAMEs: POSADA-QUINTERO, HUGO FERNANDO (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Abdomen;Abdominal Muscles;Abdominal Pain;Acceleration;Age;Analgesics;anxiety symptoms;Autonomic Dysfunction;Autonomic nervous system;Biological Markers;Brain;Clinical Trials;comorbidity;cost;Cutaneous;Data;depressive symptoms;desensitization;Development;Devices;Diagnosis;Diagnostic;Disease;drug testing;Dryness;Early Diagnosis;effective therapy;Electrocardiogram;Electrodes;Electrophysiology (science);Emotional;enema administration;Etiology;Frequencies;Glycerol;Goals;gut-brain axis;indexing;Intervention;Irritable Bowel Syndrome;Irritants;Link;Machine Learning;machine learning algorithm;machine learning model;mathematical model;Mathematics;Measures;Mental disorders;Modeling;Monitor;Mucous Membrane;multimodality;Muscle;Muscle Contraction;Natural Language Processing;neural;neural circuit;non-drug;non-opioid analgesic;Nonpharmacologic Therapy;novel therapeutics;Outcome;Pain;Pain management;Pain Measurement;pain score;pain self-management;Parasympathetic Nervous System;Pathway interactions;Patients;Pharmaceutical Preparations;Placebo Effect;Placebos;Population;Population Control;preclinical study;predictive modeling;Prevalence;Preventive;Protocols documentation;psychologic;Rectum;Recurrence;Reporting;response;Sampling;Scheme;sensor;side effect;Signal Transduction;statistical and machine learning;Stimulus;Stratification;Subgroup;Surface;Symptoms;Technology;Telemetry;Testing;Therapeutic;Time;treatment comparison;Treatment Efficacy;Viscera;Visceral;Visceral pain;Visit;wearable device

PROJECT_TITLE: Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Lead Poisoning;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative The proposed research is relevant to public health because the experiments will assess previously unconsidered mechanisms by which lead poisoning impairs development, including brain development. This project is relevant to the portion of NIH’s mission to engage in fundamental scientific discovery and develop innovative research strategies in order to protect health.

PI_NAMEs: THOMPSON, CHRISTOPHER KIRK (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adverse effects;Affect;Amphibia;Animals;Biological Metamorphosis;Brain;Brain Injuries;brain size;Cerebrospinal Fluid;Chemicals;Child;Cognitive deficits;Custom;design;Development;experimental study;expression vector;Gasoline;Gene Expression;Genes;Goals;Health;Health protection;Heavy Metals;hormonal signals;Human;Imaging Techniques;impaired brain development;Impairment;in utero;in vivo imaging;innovation;insight;knock-down;Lead;Lead Poisoning;Liver;Measures;Mediating;Mental Retardation;Mission;Molecular;neurogenesis;Neuronal Differentiation;neurotoxicity;novel strategies;Outcomes Research;overexpression;Paint;Plasmids;Plumbing;Predisposition;Process;Proliferating;Protein Biosynthesis;protein expression;protein function;Proteins;Proteomics;Protocols documentation;Public Health;Rana;Regulation;Research;Resolution;Source;Structure of choroid plexus;Tadpoles;Techniques;Testing;thyroid disruption;Thyroid Function Tests;Thyroid Hormones;Thyroxine;United States;United States National Institutes of Health;Vertebral column;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: Does lead (Pb) poisoning impair brain development by affecting how thyroid hormone gets into the brain?

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Kidney transplantation is a life-saving procedure for patients with end-stage kidney disease, however, organ shortage is a global crisis. In the present proposal, we will examine the role of an electric field (i-SMEF) in a protection against ischemic injury and improvement of transplanted graft function.

PI_NAMEs: BUGGS, JACENTHA LYNN;CHEN, WEI ;LIU, RUISHENG  (contact);WANG, LEI

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adaptive immune response;Adult;anaerobic glycolysis;Apoptosis;Blood Vessels;cell injury;Cell Volumes;Cells;Cryopreservation;Cultured Cells;Data;design;Development;electric field;End stage renal failure;Equilibrium;exhaust;Exhibits;experience;Family suidae;Flushing;Generations;Glucose;graft function;Graft Survival;Histology;Hour;Hypoxia;Impairment;improved;Inflammation;Inflammatory Response;Injury;injury and repair;Innate Immune Response;Integral Membrane Protein;Ions;Ischemia;ischemic injury;K ATPase;Kidney;kidney cell;kidney surgery;Kidney Transplantation;Legal patent;Life;Location;Measures;Membrane Potentials;Mitochondria;Mus;Names;Necrosis;novel;novel strategies;Operative Surgical Procedures;Organ;Organ Transplantation;Oxygen;Patients;preservation;prevent;Procedures;Production;protective effect;Publications;Pump;Rattus;Regulation;repaired;Reperfusion Injury;Risk Factors;Role;Sprague-Dawley Rats;Survival Rate;Techniques;Testing;Time;transplant model;Transplantation;Universities;Update;Vascular blood supply;Wisconsin

PROJECT_TITLE: Protection of donor kidney and transplanted graft function by modulating Na/K ATPase activity

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Corneal transplantation, or keratoplasty, is the only known curative treatment for corneal blindness, yet the cadaveric donor tissue required for this sight-restoring procedure is available to less than 2% of patients worldwide. While several different tissue-engineered corneal transplants have been proposed, designing multi- layered constructs with the long-term transparency and regenerative capacity of a human donor cornea remains a formidable challenge. Here we propose leveraging recent advances in 3D bioprinting to fabricate a bilayered, tissue-engineered cornea, with each layer fabricated from a customized biomaterial formulation with optimized print parameters to achieve the desired biofunctionality.

PI_NAMEs: HEILSHORN, SARAH C (contact);MYUNG, DAVID

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;3D Print;Acute;Affect;Alkynes;Animals;Anterior;Azides;Basement membrane;Behavior;Biochemical;Biocompatible Materials;bioink;Biological;Biological Assay;bioprinting;Blindness;Blinking;Cadaver;cell motility;Cell Survival;Cells;Chemicals;Chemistry;Cicatrix;clinical translation;cohesion;Collagen;Collagen Fibril;Collagen Type I;Cornea;corneal epithelium;Corneal Opacity;corneal scar;crosslink;curative treatments;Data;Deposition;design;Disease;DNA;Encapsulated;Engineering;Epithelial Cells;epithelial wound;Epithelium;Exhibits;Eye;fabrication;Family;Fibrosis;Formulation;Generations;Geometry;Human;Hydrogels;immunocytochemistry;Immunohistochemistry;improved;In Vitro;in vivo;Inflammation;injured;Injury;Keratoplasty;Lamellar Keratoplasty;Measurement;mechanical properties;Mechanics;Metabolic;Microscopy;migration;Modeling;monolayer;Natural regeneration;neovascularization;New Zealand;Oryctolagus cuniculus;Paracrine Communication;Patients;Persons;Phenotype;Physiologic Intraocular Pressure;Play;pre-clinical;Printing;Procedures;Proliferating;Property;Proteins;Quantitative Reverse Transcriptase PCR;re-epithelialization;Refractometry;regenerative;Regenerative capacity;Reporting;response;Rheology;Role;second harmonic;Shapes;sight restoration;Signal Transduction;stem cell engraftment;stromal progenitor;Structure;Technology;Testing;therapy design;Thick;Thinness;Time;Tissue Donors;Tissue Engineering;Tissues;tonometry;translational potential;Visual impairment;Wound models

PROJECT_TITLE: 3D bioprinting of a bilayered, tissue engineered cornea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


NIH_SPENDING_CATS: Aging;Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung

ORG_CITY: NEW YORK

PHR: Older adults with asthma have diminished perception of airway expiratory obstruction, which may contribute to poor outcomes. We conducted a pilot randomized trial of an intervention that trains older patients with asthma to better perceive airway obstruction and coupled it with motivational interviewing to improve asthma self care and demonstrated improvements in several clinical outcomes. We now propose a fully powered trial to test the intervention’s efficacy for clinical and self-care outcomes and examine potential mediation pathways via increased used of inhaled corticosteroids.

PI_NAMEs: FEDERMAN, ALEX D;FELDMAN, JONATHAN M.;WISNIVESKY, JUAN P (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adherence;Adrenal Cortex Hormones;Affect;Agonist;Air Movements;airway obstruction;Area;Asthma;asthma exacerbation;asthma inhaler;attentional control;Awareness;Behavior;behavior change;Belief;Child;Clinical;clinical care;cohort;Combined Modality Therapy;comparison control;Control Groups;Counseling;Coupled;Couples;Data;Dose;Education;Educational Intervention;effectiveness analysis;efficacy evaluation;efficacy testing;Emergency department visit;experience;experimental study;Feedback;follow-up;Forced expiratory volume function;group intervention;Group Interviews;Hospitalization;Hospitals;improved;improved outcome;Individual;Inhalation;inner city;innovation;Intervention;intervention participants;Length of Stay;Link;Maintenance;Measures;Mediating;Mediation;medication compliance;Minority;Minority Groups;Morbidity - disease rate;motivational enhancement therapy;Obstruction;older adult;older patient;Outcome;Participant;Pathway interactions;patient population;Patient Self-Report;Patients;Peak Expiratory Flow;Perception;Pharmaceutical Preparations;Population;post intervention;Public Health;Publishing;pulmonary function;Quality of life;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;Resources;Risk;secondary analysis;Self Care;Self Care outcome;Self Efficacy;Self Management;Standardization;Testing;Time;Training;treatment effect;Treatment Efficacy;United States;young adult

PROJECT_TITLE: A randomized trial of perception of airflow limitation training to improve outcomes for older adults with asthma

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT This proposal aims to engineer the membrane of extracellular vesicles as a means to systemically present specific ligands that can restore cellular function after tissue damage due to inflammation. Success of the proposed studies will lead to a new nanotechnology platform that can be broadly used to promote tissue repair and regeneration.

PI_NAMEs: PAJCINI, KOSTANDIN ;SHIN, JAE-WON  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Address;Adhesions;Area;Atomic Force Microscopy;Binding;Biocompatible Materials;Biological;Biology;Biophysics;Blood Vessels;Bone Marrow Ablation;Capsid Proteins;Cell membrane;cell motility;Cell Physiology;Cell secretion;Cell Surface Receptors;Cells;Cellular biology;Characteristics;Chemistry;chemotherapy;Chimeric Proteins;Data;design;Development;Edema;efficacy testing;Endothelial Cells;Endothelium;Endotoxemia;Engineering;Evolution;experience;extracellular;extracellular vesicles;Formulation;Gene Targeting;Genetic;Genetic Transcription;Goals;Hindlimb;Homeostasis;Image;immune function;in vivo;inducible gene expression;Inflammation;inhibitor;Injury;insight;interdisciplinary approach;Ischemia;Ligands;Lipids;Lipopolysaccharides;Liposomes;Lung;mechanical force;Mediating;member;Membrane;Membrane Lipids;Modality;Molecular;Molecular Biology;mouse model;Mouse Strains;multidisciplinary;Mus;nanomedicine;nanoscale;Nanotechnology;nanotechnology platform;nanovesicle;notch protein;Notch Signaling Pathway;Organ;Osmotic Pressure;Outcome;Pathway interactions;Property;public health relevance;receptor;Receptor Activation;reconstitution;regenerative;Reporter;Research Personnel;Residual state;response;restoration;Signal Pathway;Signal Transduction;success;surface coating;technology platform;Testing;Therapeutic;Therapeutic Effect;tissue injury;tissue regeneration;tissue repair;Tissues;uptake;Vascular Permeabilities;Vascularization;Venus;Water;water channel

PROJECT_TITLE: Engineering extracellular vesicles for therapeutic receptor activation

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative It is a common clinical occurrence that neuroimaging scans obtained in the course of routine care discover covert cerebrovascular disease, comprising covert brain infarction and white matter disease. These patients are at very high risk of future stroke and dementia, but there are no proven preventive treatments or guidelines for initiating risk factor-modifying therapy, in part because the patients are difficult to identify. We have previously developed a natural language processing (NLP) algorithm that accurately identifies these patients at scale; we now propose to use this large cohort with NLP-labeled scans to develop a deep learning model to identify covert cerebrovascular disease and other radiomic features to predict stroke and dementia from routinely obtained neuroimages.

PI_NAMEs: KENT, DAVID M (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Age;age related;Algorithms;American Heart Association;American Stroke Association;Articulation;Artificial Intelligence;Awareness;Biological Markers;Blood Vessels;Brain;Brain Infarction;burden of illness;Cerebral small vessel disease;Cerebrovascular Disorders;Clinical;clinical care;clinical practice;clinically relevant;Code;cohort;deep learning;deep learning algorithm;deep learning model;Dementia;dementia risk;Development;Electronic Health Record;epidemiology study;Evaluation;Future;Goals;Guidelines;Head;Hemorrhage;Heterogeneity;high risk;high risk population;ICD-9;Image;Image Analysis;Impaired cognition;Incidence;Incidental Findings;Infarction;information gathering;insight;Integrated Health Care Systems;Label;Lesion;Location;Magnetic Resonance Imaging;model development;Modeling;Modernization;Natural Language Processing;neural network;neuroimaging;neuroimaging marker;novel;Older Population;Outcome;Patients;Pattern;Population;predictive marker;Predictive Value;Prevalence Study;Prevention Research;Preventive treatment;Primary Prevention;prognostic;Prognostic Marker;prognostic significance;prognostic value;Protocols documentation;Provider;radiomics;Recommendation;Reporting;Research;Risk Factors;routine care;Scanning;screening;Severity of illness;Shapes;Standardization;Stroke;Stroke prevention;stroke risk;Structure;Subgroup;Testing;Text;Ventricular;White Matter Disease;X-Ray Computed Tomography

PROJECT_TITLE: Covert Cerebrovascular Disease Detected by Artificial Intelligence (C2D2AI): Pragmatic Neuroimaging Biomarkers for Future Stroke and Dementia Risk


ORG_DEPT: NEUROLOGY

PHR: Project Narrative Guillain-Barré syndrome (GBS) is an inflammatory condition in which peripheral nerves are attacked by patient's own immune system and current treatments are ineffective in a substantial proportion of patients, who are left with permanent disability. GBS is mediated by autoantibodies and/or autoreactive T cells directed against axonal or myelin antigens that initiate immune attack against peripheral nerves and macrophage lineage cells play critical role in eventual damage to the nerve fibers. This project proposes to test a treatment stratgey that can reduce macrophage inflammation in the nerves of animal models relevant to GBS. These results may facilitate development of new therapies for patients with GBS.

PI_NAMEs: SHEIKH, KAZIM A (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute;Acute Disease;Adhesions;Affinity;animal data;Animal Model;antagonist;Antibodies;Antigens;Autoantibodies;Autoimmune Responses;Autoimmunity;autoreactive T cell;Axon;axonal degeneration;Binding;Bone Marrow;Cell Lineage;Cell Physiology;Cells;Chemotaxis;Chimera organism;Chronic Inflammatory Demyelinating Polyradiculoneuropathy;Clinical Trials;Coculture Techniques;Colony-Stimulating Factors;comparative efficacy;CSF1R gene;Demyelinations;Development;Disease;Disease Management;disease model;efficacy evaluation;Endoneuriums;evidence based guidelines;Gangliosides;Glycolipids;Guillain Barré Syndrome;Human;Immune;Immune response;Immune system;immunocytochemistry;Immunoglobulin A;immunomodulatory therapies;Immunotherapy;improved;In Situ Hybridization;ineffective therapies;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;innate immune pathways;Innate Immune System;Intravenous Immunoglobulins;Label;Left;Lifelong disability;Ligands;Macrophage;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Malignant Neoplasms;Mediating;Membrane;migration;Modality;Modeling;Monoclonal Antibodies;monocyte;Motility;Mus;mutant;Myelin;Myelinated nerve fiber;Nature;Nerve;Nerve Fibers;nerve injury;Nerve Tissue;Neurologic;Neuropathy;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel therapeutic intervention;novel therapeutics;Paralysed;Pathogenesis;Pathologic;Patients;Peripheral nerve injury;Peripheral Nerves;Pharmaceutical Preparations;pharmacologic;Phase;Plasma Exchange;Play;Poliomyelitis;Polysaccharides;Population;pre-clinical;Proliferating;Public Health;Publishing;receptor;receptor expression;Receptor Signaling;receptor-mediated signaling;Recovery;recruit;Regulation;repository;Resistance;response;Role;Schwann Cells;Signal Transduction;small molecule inhibitor;Specificity;Specimen;synergism;T cell response;T-Lymphocyte;Testing;Tissues;Transgenic Organisms;translational therapeutics;validation studies;Walking

PROJECT_TITLE: Modulation of CSF1R Signaling to Treat Inflammatory Neuropathies

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Nutrition;Obesity;Physical Activity;Prevention;Sleep Research;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Emerging adult women are at high risk for obesity, proinflammatory behaviors (insufficient sleep, intake of highly processed foods, declines in physical activity), and psychological stressors—all of which perpetuate chronic inflammation and contribute to insufficient weight loss treatment response. The proposed study builds upon promising preliminary data demonstrating that an integrated lifestyle intervention (ILI) addressing all of these risk factors through the lens of inflammation produced clinically meaningful improvements in depression, anxiety, perceived stress, as well as weight loss. We will now examine the potential of ILI to positively influence adiposity and biomarkers of inflammation and cardiometabolic risk over longer-term follow up, compared with a developmentally adapted behavioral weight loss arm.

PI_NAMEs: LAROSE, JESSICA GOKEE (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Adult women;Age;age group;Age Years;Anxiety;arm;Behavior;behavior change;Behavior monitoring;Behavioral;Biological Markers;Black race;Blood Pressure;Body fat;Body mass index;Body Size;Body Weight decreased;Calories;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chronic;Clinical;clinically significant;Cognitive;Collection;comparative efficacy;comparison intervention;Coupled;cytokine;Data;depressive symptoms;Development;dietary;digital tool;distress tolerance;efficacy trial;emerging adult;emerging adulthood;Enrollment;Ethnic Origin;Event;experience;Exposure to;Female;follow-up;Food;Future;Gender;Goals;Health;high risk population;High Risk Woman;Hour;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;Inflammation;Inflammatory;Informal Social Control;Intake;Interleukin-1 beta;Interleukin-6;Intervention;intervention participants;Latina;lens;Life;lifestyle intervention;Link;Lipids;Malignant Neoplasms;men;Mental Depression;Modeling;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;obesity management;obesity risk;obesity treatment;Outcome;Overweight;Participant;Pattern;perceived stress;Phase;Physical activity;pilot trial;Population;Prevalence;Process;programs;psychologic;Psychological Stress;psychological stressor;psychological symptom;Race;Randomized;randomized, clinical trials;recruit;response;Risk;Risk Factors;Schedule;Serum;Signal Transduction;single episode major depressive disorder;Sleep;Sleep Deprivation;Stress;stress symptom;stressor;Testing;therapy development;TNF gene;Training;treatment effect;Treatment outcome;treatment response;Urine;waist circumference;Weight;weight loss intervention;weight loss program;Woman

PROJECT_TITLE: An Integrated Lifestyle Intervention to Promote Cardiometabolic Health among Emerging Adult Women

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: We discovered a novel antiviral natural product that is produced by enzymes encoded with the human genome. This natural product can inhibit replication of a wide range of viruses, including Zika virus, hepatitis C virus, influenza virus, rhinovirus, respiratory syncytial virus and HIV. The goal of this proposal is to define the underlying mechanisms responsible to this broad antiviral activity and to understand its role in normal physiology. These new insights might lead to new antiviral therapeutic strategies.

PI_NAMEs: GROVE, TYLER L (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 26S proteasome;Adipose tissue;Anti-viral Agents;ATP-Binding Cassette Transporters;Automobile Driving;Biochemical;Biological Process;Biology;Brown Fat;Cell Maturation;Cell Physiology;Cells;Cholesterol Homeostasis;Chondrocytes;Collaborations;Complex;Cytomegalovirus;Data;Dendritic Cells;Dengue;Dengue Virus;Development;DNA;DNA Viruses;DNA-Directed RNA Polymerase;drug development;Endoplasmic Reticulum;Enzymes;Family;Family Picornaviridae;Fatty Acids;Flavivirus;Genetic Transcription;Goals;Hepatitis C virus;HIV;Human;Human Genome;In Vitro;in vivo;Inflammation;influenzavirus;inhibitor;insight;Interferon Type I;Interferons;IRAK1 gene;Iron;Lead;Ligase;Macrophage;Mediating;member;Metabolic;Metabolism;Methionine;Microbe;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Mitochondrial RNA;mRNA capping;multicatalytic endopeptidase complex;Natural Immunity;Natural Products;Nature;novel;oxidation;Oxygen;Physiological Processes;Physiology;Play;Positioning Attribute;Process;Production;programs;protein degradation;Proteins;Publishing;Regulation;Respiratory syncytial virus;response;Rhinovirus;Ribonucleotides;Ribosomal Proteins;Ribosomes;RNA;RNA Splicing;RNA Viruses;RNA-Directed RNA Polymerase;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Pathway;Signal Transduction;small molecule;Sulfur;Thermogenesis;Time;tool;TRAF6 gene;transcriptome sequencing;Transferase;Translations;ubiquitin ligase;Ubiquitination;viperin;Viral;Viral Physiology;Viral Proteins;Virus;Virus Replication;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Deciphering the role of ddhCTP in viperin-related functions

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Relevance to Public Health: This work will directly benefit civilians, caregivers as well as U.S. service mem- bers and veterans by: 1) unveiling potential neural targets of future pain reducing treatments; 2) developing a non-invasive diagnostic and predictive assessment of neuropathic pain, and 3) unmasking the relationship be- tween quantitative connectome measures and psychosocial aspects of the pain experience after SCI. Having an understanding of the mechanism of pain following SCI injury is critical to further provide a referral mecha- nism for intervention and/or modification of ongoing intervention that will aid to ameliorate the debilitating consequences of neuropathic pain in individuals with SCI.

PI_NAMEs: ALIZADEH, MAHDI  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute Pain;Affective;allodynia;Anterior;Area;Assessment tool;Biological Markers;Brain;brain based;Brain region;candidate selection;Caregivers;Cerebrum;Chronic;chronic neuropathic pain;chronic pain;cingulate cortex;Clinical;clinical efficacy;clinical pain;Clinical Treatment;Clinical Trials;Complex;connectome;Deep Brain Stimulation;Development;Diagnosis;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;dynamic system;effective therapy;endophenotype;Esthesia;experience;Functional Magnetic Resonance Imaging;Future;Goals;Graph;graph theory;Human;Hyperalgesia;Image;improved;Individual;Individual Differences;Injury;Interruption;Intervention;Life;Literature;Magnetic Resonance Imaging;Maintenance;mathematical model;Measures;Medial;Methods;Modification;Multimodal Imaging;multimodal neuroimaging;multimodality;Network-based;neural;neural network architecture;Neurobiology;neurochemistry;neuroimaging;neuroimaging marker;Neurons;neuroregulation;Neurostimulation procedures of spinal cord tissue;Nodal;noninvasive diagnosis;Numeric Rating Scale;Opioid;Outcome;Pain;Pain management;Pain Measurement;pain processing;pain reduction;painful neuropathy;Participant;Pathway Analysis;Pathway interactions;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Pattern;Persons;pharmacologic;Phenotype;Population;Positron-Emission Tomography;post intervention;preclinical study;Prefrontal Cortex;Process;Prognostic Marker;Protocols documentation;psychologic;psychosocial;Public Health;Rehabilitation therapy;Research;Rest;risk prediction;Selection Criteria;Sensory;sensory cortex;Sensory Disorders;service member;side effect;Somatosensory Cortex;Spinal Cord;Spinal cord injury;spinal cord injury pain;Spinal cord injury patients;Spinal Ganglia;Spinothalamic Tracts;statistics;Structure;Techniques;Testing;Thalamic structure;tool;Translational Research;Treatment outcome;Veterans;Work

PROJECT_TITLE: Neuroimaging and Connectome Analysis as a Diagnostic and Prognostic Biomarker of SCI Induced Neuropathic Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE Pancreatic cancer usually is detected at a late stage when it is uncurable. This proposal focusses on identifying reliable early detection markers that would allow discovering tumors at a time when they are still local. Overall, our project will identify secreted protein markers that are detectable in easily accessible liquid biopsies and distinguish between pancreatic non-cancerous lesions and cancerous lesions.

PI_NAMEs: STORZ, PETER  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Arginine deiminase;biomarker identification;biomarker panel;Biopsy;Biopsy Specimen;Cancerous;Carcinoma in Situ;Data;Detection;Development;differential expression;Duct (organ) structure;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;Excision;extracellular;Fibrinogen;Generations;Goals;Inflammation;innovation;Lesion;liquid biopsy;Liquid substance;Malignant neoplasm of pancreas;Malignant Neoplasms;Metaplasia;Microdissection;Neoplasm Metastasis;novel;Operative Surgical Procedures;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Patients;Pattern;Prognosis;protein biomarkers;Protein Secretion;Resected;Serum;Specificity;successful intervention;Survival Rate;Testing;Therapeutic;Time;Tissues;tool;transcriptome sequencing;tumor;Urine

PROJECT_TITLE: Deiminated molecules as markers for developing pancreatic cancer - A1

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative Heart failure drugs help improve cardiac performance. This study compares an FDA-approved drug with a promising new drug to answer why one drug might cause irregular heart rhythms as a fatal side effect while another is safe. The understanding of how these drugs work will reveal exciting new cell processes to enable future heart failure drug development towards increased efficacy and minimal side effects.

PI_NAMEs: MULLER, GRACE KIM (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Agonists;Adrenergic beta-Antagonists;Adult;Arrhythmia;beta-adrenergic receptor;Biosensor;Calcium;calcium indicator;Cardiac;Cavia;Cell Physiology;Cells;Chicago;Chronic;Clinical;clinically relevant;Computer Models;confocal imaging;Conscious;Coupling;Curiosities;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Cyclic Nucleotides;Dangerousness;Data;Devices;Disease;drug development;Echocardiography;Electric Stimulation;Electrocardiogram;Electrophysiology (science);FDA approved;Fibrosis;Fluorescence Resonance Energy Transfer;Future;Gene Modified;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Heart;Heart Contractilities;Heart failure;heart function;heart rhythm;Image;improved;in vivo;inhibitor;innovation;Innovative Therapy;Investigation;Ions;Knockout Mice;Knowledge;L-Type Calcium Channels;Laser Scanning Confocal Microscopy;Long-Term Effects;Maps;Measures;Mediating;Membrane;Milrinone;Modeling;Mus;Muscle Cells;Myocardial;next generation;novel;novel therapeutics;Optics;Oryctolagus cuniculus;patch clamp;Pathologic;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Phosphodiesterase Inhibitors;phosphodiesterase IV;phosphoric diester hydrolase;Phosphorylation;Physiological;Postdoctoral Fellow;Predisposition;Protocols documentation;rational design;Regional Perfusion;Regulation;research clinical testing;Risk;Role;Sarcolemma;Sarcoplasmic Reticulum;side effect;Signal Pathway;Signal Transduction;simulation;spatiotemporal;Specific qualifier value;Stress;Techniques;Telemetry;Testing;Therapeutic;Tissues;trial design;Universities;Ventricular Arrhythmia;Work

PROJECT_TITLE: Phosphodiesterase 1 (PDE1) Regulation of Myocardial Calcium and Function

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Monocytes / macrophages play a critical role in antibody therapy for cancer. However, these cells are in a suppressed state within chronic lymphocytic leukemia (CLL). We have found that activation of a particular intracellular receptor can reverse this suppressed state and lead to stronger antitumor responses. Here, we propose to study how a ligand that activates this receptor works, in order to justify clinical testing of this ligand as a potential treatment for CLL.

PI_NAMEs: BUTCHAR, JONATHAN P.;TRIDANDAPANI, SUSHEELA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adjuvant Therapy;Agonist;Animals;Antibodies;Antibody Therapy;Antitumor Response;Autologous;B-Lymphocytes;Blood;burden of illness;cancer therapy;cancer type;Cell Communication;Cell Line;Cell Maturation;Cells;chemotherapy;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;clinical development;Clinical Trials;cytokine;Cytometry;cytotoxic;cytotoxicity;Data;Disease;Down-Regulation;European;experimental study;Functional impairment;functional outcomes;Generations;Goals;Human;Immune;immune modulating agents;Immuno-Chemotherapy;Immunologic Adjuvants;improved;improved outcome;in vivo;inhibitor;Inositol;Interferon Type II;Interleukin-12;knockout animal;Ligands;Macrophage;Measures;Mediating;Medicine;Modeling;Molecular;Monoclonal Antibodies;monocyte;mouse model;MS4A1 gene;Myeloid Cells;Natural Killer Cells;neoplastic cell;NK Cell Activation;novel;Nurses;Osteosarcoma;Patients;PECAM1 gene;Phagocytosis;Phenotype;Phosphoric Monoester Hydrolases;Play;Production;Proliferating;Publishing;receptor;research clinical testing;response;Role;Safety;Signal Transduction;Signaling Molecule;Spleen;Surface;synergism;Testing;Therapeutic;TLR8 gene;TNF gene;tumor;Tumor-associated macrophages;Up-Regulation;Validation;Withdrawal;Work

PROJECT_TITLE: Novel enhancement of antibody therapy through NOD2 activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIO-D (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Disease;Substance Misuse

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Alcohol-associated liver disease is a major clinical problem. This project will evaluate the role of histone lysine methylation enzymes in development, progression and resolution of alcohol induced liver fibrosis. We will study sex-specific and sex-independent mechanisms and evaluate how they contribute to disease progression in mouse models and in patients with alcohol-associated liver disease.

PI_NAMEs: TIKHANOVICH, IRINA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: alcohol exposure;alcohol response;Alcoholic Liver Diseases;Alcohols;Androgen Receptor;AODR mortality;Binding;bioinformatics tool;Cell Communication;Cells;ChIP-seq;Chromatin;Clinical;Coculture Techniques;Communication;Complex;cytokine;Data;Development;Disease;Disease Progression;DNA Binding Domain;Endothelial Cells;Enzymes;Epigenetic Process;ESR1 gene;Ethanol;Event;experimental study;Female;Fibrosis;Gene Expression;Genes;Genetic Transcription;Gonadal Steroid Hormones;Hepatic;Hepatocyte;histone demethylase;histone modification;Histones;Hormones;Human;Immunoprecipitation;In Vitro;in vivo;Inflammation;Inflammatory;insight;KDM5B gene;Knock-out;Knockout Mice;Kupffer Cells;Link;Liver;Liver diseases;Liver Fibrosis;LoxP-flanked allele;Lysine;Macrophage;male;Mediating;Mediator;Methylation;Molecular;mouse model;Mus;Nature;novel;novel therapeutic intervention;Nuclear Receptors;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Process;Production;Profibrotic signal;programs;Proteomics;recruit;Regulation;Resolution;Role;Sampling;sex;Sex Differences;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Specificity;Stat5 protein;STAT5B gene;stellate cell;targeted treatment;Technology;Testing;Therapeutic;transcription factor

PROJECT_TITLE: The role of H3K4 demethylases in alcohol-associated liver disease development and resolution

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]