ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rehabilitation;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE This research will use innovative methods and existing data sources to examine the clinical, health system, and policy factors that impact health care use after functional disability. The population of older adults with functional disability is growing, and disability results in high levels of potentially burdensome health care use. Assessing the role of health systems and policies, such as Medicare Advantage, in shaping care for this population is critical to improving the quality of care for all older adults.

PI_NAMEs: ANKUDA, CLAIRE KATHRYN (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Accident and Emergency department;Activities of Daily Living;Acute;Address;Aging;Award;Bathing;beneficiary;career;Caregivers;caregiving;Caring;Cessation of life;Characteristics;Clinical;Cohort Studies;Communities;community setting;Complex;cost;Cost Sharing;Data;Data Sources;Dementia;Development;Development Plans;disability;disabled;Disease;Economic Factors;Elderly;Enrollment;Event;experience;Family;flexibility;functional disability;functional status;Geography;Goals;Health;Health and Retirement Study;Health care facility;health economics;Health Policy;Health Services;Health Status;Health system;Healthcare;Heterogeneity;high risk;Hip Fractures;Home;Home Health Agency;hospital bed;hospital readmission;Hospitalization;improved;Individual;Individual Adjustment;innovation;insight;Institution;K-Series Research Career Programs;Leadership;Length of Stay;Link;Medical;Medicare;Medicare claim;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multiple chronic conditions;Nursing Homes;older adult;Older Population;Outcome;Outcome Study;Palliative Medicine;Patients;Pattern;Patterns of Care;Physicians;Policies;Population;Poverty Areas;Primary Care Physician;programs;Provider;Quality of Care;racial minority population;Recurrence;Reporting;Research;Research Personnel;Resources;Role;Sentinel;Shapes;Skilled Nursing Facilities;skills;social;socioeconomics;Surveys;System;Training;Translating;trend;Variant;Walking

PROJECT_TITLE: Health Care Use After Functional Disability: Opportunities to Improve the Care of Older Adults


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Amplification of the TRIM37 chromosomal locus occurs in several cancers, including ~10% of breast cancers and ~60% of neuroblastomas. This project will define how TRIM37 overexpression promotes tumor development and test a therapeutic approach for targeting this genetic fault in the clinic.

PI_NAMEs: REGOT, SERGI  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 17q;17q23;aurora B kinase;Automobile Driving;Biogenesis;brca gene;Breast;Breast Cancer Cell;cancer cell;cancer therapy;Cell Cycle Progression;Cell division;cell killing;Cell Proliferation;Cells;Centrosome;Chemicals;Chromosome Segregation;Clinic;Clinical;Collaborations;Coupled;Data;Defect;Development;Down-Regulation;effectiveness testing;Exhibits;Failure;Functional disorder;Gene Amplification;Genes;Genetic;genetic approach;genetic manipulation;Genome;Genomic Instability;Genomics;Goals;Heterogeneity;Human;Hypersensitivity;imaging approach;Inherited;inhibitor;loss of function mutation;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Microtubule-Organizing Center;Microtubules;Mitotic;Mitotic spindle;Modeling;Molecular;Mutation;neoplastic cell;Neuroblastoma;novel;novel therapeutics;Oncogenes;Oncogenic;Organelles;Organoids;overexpression;patient derived xenograft model;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;PLK1 gene;Poly(ADP-ribose) Polymerase Inhibitor;PPM1D gene;Pre-Clinical Model;preservation;Primary Neoplasm;Proliferating;Property;protein expression;Proteins;Reporting;Role;synthetic lethal interaction;Testing;Therapeutic;TP53 gene;tumor;Tumor Promotion;tumorigenesis;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: The role of TRIM37 in driving tumorigenesis and cancer-specific vulnerability to PLK4 inhibition

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will enhance programmatic and scientific capacity to facilitate innovative discovery and new understandings of environmental exposure pathways of concern to our community (e.g., water, air, emerging threats). Further, the Center will foster career development of environmental health scientists interested in tackling challenging environmental health questions facing rural Appalachia. UK-CARES will achieve these goals by providing advanced infrastructure and expertise, cross-disciplinary training and mentorship, and multidirectional community-academic partnerships to reduce health risks and health disparities in rural Appalachia.

PI_NAMEs: HAYNES, ERIN N (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acceleration;Address;Affect;Air;air contaminant;Air Pollution;Analytical Chemistry;Appalachian Region;Arsenic;Asthma;base;Bioinformatics;career;career development;Career Mobility;Chemicals;Chromium;Chronic Disease;Chronic Obstructive Pulmonary Disease;citizen science;Clinical Data;clinical decision-making;Clinical Research;Coal Mining;Colorectal Cancer;Communication;Communities;community academic partnership;community engaged research;community engagement;Community Outreach;community partners;Complex;Core Facility;Data Science;Dedications;design;Diabetes Mellitus;Discipline;disease disparity;Disparity;Dissemination and Implementation;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Pollutants;Environmental Science;equity, diversity, and inclusion;experience;exposure pathway;Exposure to;Faculty;Fostering;Foundations;Funding;Geology;Goals;Grant;Health;health assessment;health communication;health disparity;health equity;Health Promotion;health science research;Health Sciences;Heart;Heart Diseases;improved;Incidence;Infrastructure;innovation;interest;Joints;Kentucky;Knowledge;Lead;Learning;Life Style;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medically Underserved Area;member;Mentors;Mentorship;Mission;Molecular Toxicology;multidisciplinary;Natural Gas;Nickel;novel;Obesity;Oils;organic contaminant;outreach;Particulate;Pilot Projects;Policies;Policy Developments;Population;population health;Procedures;Process;programs;Public Health;Radon;Reproducibility;Research;research facility;Research Personnel;Research Project Grants;research study;Resources;responsible research conduct;Risk;Risk Factors;Rural Appalachia;rural dwellers;Science;Scientist;Services;Severe Acute Respiratory Syndrome;skills;socioeconomic disadvantage;success;Superfund;synergism;tobacco smoke exposure;Trace Elements;Training;Translating;translational pipeline;Translational Research;Universities;wastewater surveillance;Water;Water Pollutants;water quality;waterborne

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: HAHN, ELLEN J (contact)

PROJECT_TERMS: Administrator;Affect;Analytical Chemistry;Appalachian Region;career;career development;Chronically Ill;Clinical;Collaborations;college;Communication;Communities;community academic partnership;community center;community engagement;Community Outreach;community partners;Core Facility;Decision Making;Dedications;design;Discipline;Discipline of Nursing;Disparity;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Environment;Environmental Exposure;Environmental Health;environmental justice;Environmental Science;Evaluation;Event;Faculty;Funding;Goals;Grant;Health;health science research;Health Sciences;Healthcare;higher education;improved;Institution;Kentucky;Lead;Leadership;Learning;Letters;Manuscripts;meetings;member;Mentors;Mentorship;Mission;Monitor;National Institute of Environmental Health Sciences;operation;organic contaminant;organizational structure;Outcome;Persons;Pilot Projects;Population;Procedures;Process;Productivity;Professional Organizations;Program Development;programs;Public Health;Public Relations;Publishing;Qualifying;recruit;Reporting;Research;Research Personnel;Resource Sharing;responsible research conduct;Risk;Rural Appalachia;Science;Scientist;Senior Scientist;Series;Services;social media;socioeconomic disadvantage;Strategic Planning;success;Superfund;Trace Elements;Training;Translating;translational pipeline;Translational Research;Underrepresented Minority;Universities;Wages;waterborne;web site;working group

PROJECT_TITLE: Center for Appalachian Research in Environmental Sciences-Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Stroke

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE These studies are relevant to public health for two reasons. First, they will identify the molecular alterations that contribute to the proatherogenic functions of CD8+ T cells and their association to plaque pathology and cardiovascular events. Secondly, they will determine whether these alterations are causally implicated to atherosclerosis in vivo using innovative systems models of disease.

PI_NAMEs: GIANNARELLI, CHIARA  (contact)

PROGRAM_OFFICER_NAME: OLIVE, MICHELLE

PROJECT_TERMS: Acute;Affect;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Biological Models;Cardiovascular Diseases;Cardiovascular system;Carotid Artery Plaques;Carotid Endarterectomy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Complement;Coronary Arteriosclerosis;Coronary heart disease;cytotoxic;cytotoxicity;Data;design;disability;Disease;disease model;Disease Progression;Down-Regulation;effector T cell;Event;exhaust;exhaustion;experience;Frequencies;Future;Genes;Genetic Markers;Genetic Polymorphism;Genetic Transcription;genome-wide analysis;Goals;Granzyme;healing;High Fat Diet;Histologic;Human;human data;ID2 gene;Immune;Immunotherapy;in vivo;innovation;Knowledge;Link;Mediating;Medicine;Memory;Molecular;Molecular Target;mortality;Mus;Myocardial Infarction;Nature;Organ Donor;Outcome;Pathologic;Pathology;Patients;Phenotype;prevent;programmed cell death protein 1;protein biomarkers;Proteins;Public Health;Publishing;Regulation;residence;Rest;risk variant;Role;Rupture;Signal Pathway;single cell analysis;single-cell RNA sequencing;Stroke;stroke patient;Surgical margins;T cell infiltration;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tissue resident memory T cell;Tissues;transcription factor;Variant;Work

PROJECT_TITLE: Dissecting the role of CD8+ T cells in atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH For breast cancer tumors to survive and grow, they must escape detection and elimination by the immune system. Our previous research has suggested that the hormone progesterone may play a role in altering immune signaling pathways in breast cancer cells. The proposed study uses new sequencing tools and animal models to determine whether progesterone decreases the ability of immune cells to invade and recognize tumor cells.

PI_NAMEs: WERNER, LAURYN ROSE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Affect;Animal Model;Anti-Progestin;anti-tumor immune response;Biological Assay;Breast Cancer Cell;Breast Epithelial Cells;Cancer Etiology;candidate identification;Cell Physiology;Cell Separation;Cells;Cessation of life;chemokine;Clinical Trials;comparison control;Cross-Priming;cytokine;Cytokine Signaling;Data;Dendritic cell activation;Dendritic Cells;Detection;Development;Diphtheria Toxin;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Exhibits;Female;Flow Cytometry;genetic signature;Growth;Growth and Development function;Hormones;Human;Immune;immune clearance;Immune signaling;Immune system;Immune Tolerance;immunoregulation;Immunosuppression;In Vitro;in vivo;Individual;Infiltration;insight;Interferon Type I;Invaded;Lead;Link;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;mammary gland development;Measures;Mediating;Modeling;mouse model;Mus;neoplastic cell;novel;overexpression;Placebos;Play;Progesterone;Progesterone Receptors;Progestins;Public Health;Publications;Publishing;receptor expression;Receptor Signaling;recruit;Reporting;Repression;Research;Risk;RNA analysis;Role;Sampling;Signal Pathway;single-cell RNA sequencing;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;tool;Transgenic Mice;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Promotion;tumorigenesis;Western Blotting;Work

PROJECT_TITLE: Progesterone promotes mammary gland tumorigenesis through immunosuppressive effects on dendritic cells


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed studies will develop a comprehensive understanding of the molecular pathways that control the spread and recurrence of head and neck cancer. This information will provide the foundation to appropriately select patients who will respond to existing treatments, and identify novel strategies to sensitize tumors to treatment. Ultimately this will improve survival of patients with head and neck cancer.

PI_NAMEs: D'SILVA, NISHA J (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: cancer cell;cancer recurrence;Development;epithelial to mesenchymal transition;Foundations;Head and Neck Cancer;improved;Invaded;Knowledge;Link;malignant mouth neoplasm;Molecular;novel;novel strategies;Pathway interactions;Patient Selection;Patients;Radiation Protection;Recurrence;Resistance;Resistance development;Risk;treatment strategy;tumor;tumor progression;Work

PROJECT_TITLE: Improving Survival in Oral Cancer by Disruption of Tumor Progression


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PI_NAMEs: BAUER, JOHN ANTHONY (contact)

PROJECT_TERMS: Address;Analytical Chemistry;Appalachian Region;Area;Back;biobank;career development;Categories;Clinical;Clinical Data;clinical practice;Clinical Research;Clinical Sciences;cohort;Collaborations;Communication;Communication Research;Communities;community academic partnership;community building;community collaboration;community engagement;community partners;Consultations;Core Facility;Data;Data Analyses;data management;Data Science;Development;Dimensions;Disasters;Educational workshop;Elements;Environmental Exposure;Environmental Health;Environmental Science;Evaluation;Fostering;Funding;Goals;Growth;Health;health assessment;health communication;health science research;Health Sciences;health training;high risk;Human;improved;Infrastructure;innovation;Institution;Institutional Review Boards;Integrative Medicine;Kentucky;Laboratories;Leadership;Link;meetings;member;Methodology;Methods;Modeling;Molecular Toxicology;multidisciplinary;National Institute of Environmental Health Sciences;novel;novel strategies;operation;Output;Patients;Peer Review;Pilot Projects;Policy Maker;prevent;Process;Program Development;Public Health;Public Health Practice;Publishing;Reporting;repository;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;response;Review Literature;Role;Sampling;Science;Scientist;service coordination;Services;Statistical Data Interpretation;Strategic Planning;Structure;success;Testing;Toxicology;Training;translational health science;translational impact;translational pipeline;Translational Research;Universities;Water;waterborne;Work

PROJECT_TITLE: Center for Appalachian Research in Environmental Sciences-Integrated Health Sciences Facility Core (IHSFC)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: Project Narrative – Overall Our goal is the characterization of immune signatures (IMS) of T cell subsets associated with a wide-range of common respiratory pathogens in the context of natural infection, disease, and vaccination. These studies will build on our current success as a HIPC center and employ longitudinal approaches to investigate the role of circulating and lung tissue-resident antigen-specific T cells in protective immune responses. To accomplish this goal, we will profile pathogen-specific CD4 and CD8 memory T cells, lung tissue-resident memory T cells and their T cell receptor (TCR) repertoires using unbiased single-cell assays.

PI_NAMEs: SETTE, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Address;Adult;antigen-specific T cells;Antigens;Atlases;Attenuated;Bacille Calmette-Guerin vaccination;Bacteria;biomarker panel;Blood;Bordetella pertussis;burden of illness;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Assay;Clinical;cohort;Common Cold;Communicable Diseases;Communication;Coronavirus;cost effective;current pandemic;data management;design;Disease;Enrollment;Ensure;epigenome;Epitopes;Evolution;Flow Cytometry;Funding;Generations;Goals;Immune;Immune response;Infection;Influenza;innovation;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Lower respiratory tract structure;Lung;Molecular;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;pathogen;pathogenic fungus;Pertussis;Pertussis Vaccine;Phenotype;Play;Pneumovirus;programs;Property;protein purification;Recurrence;Research Design;Resources;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Infections;response;Risk;Role;SARS-CoV-2 infection;Services;Severity of illness;single cell ATAC-seq;Sorting;Streptococcus pneumoniae;Structure of parenchyma of lung;success;synergism;Systems Biology;T cell response;T memory cell;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Time;tissue resident memory T cell;Tissues;transcriptome;transcriptomics;unvaccinated;Upper respiratory tract;Vaccinated;Vaccination;vaccine platform;Vaccinee;Vaccines;Viral;Viral Vector;Virus;Yellow Fever

PROJECT_TITLE: Respiratory pathogen-specific T cell signatures following vaccination, natural infection, and treatment


PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PI_NAMEs: VIJAYANAND, PANDURANGAN  (contact)

PROJECT_TERMS: 2019-nCoV;active method;Address;Adult;antigen challenge;antigen-specific T cells;Aspergillus;Atlases;Authorization documentation;Bacille Calmette-Guerin vaccination;bioinformatics pipeline;Biological;Bronchoalveolar Lavage;Bronchoscopy;Candida;Cells;central database;Clinical;clinical center;Clinical Data;clinical investigation;Clinical Research;cohort;Collaborations;Common Cold;Coronavirus;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Data;Data Analyses;Data Collection;data management;Diagnosis;Disease;Documentation;Enrollment;Ensure;epigenome;experience;experimental study;fungus;Genus Mycobacterium;Geographic Locations;Healthcare;Human;human leukocyte antigen testing;Human Resources;Human Subject Research;Immune;Immunization;Individual;Infection;Influenza;influenza virus vaccine;Institution;Leadership;Longitudinal cohort;Lung;Malignant neoplasm of lung;Measures;Methods;Modeling;Monitor;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Ohio;Operative Surgical Procedures;Outcome;pathogen;Patients;Peripheral Blood Mononuclear Cell;Pertussis;Pertussis Vaccine;Peru;Plasma;Pneumococcal vaccine;Pneumovirus;pre-pandemic;Process;programs;Prophylactic treatment;prospective;Pulmonary Challenge;Quality Control;Records;recruit;Research;Resolution;Resources;respiratory pathogen;Respiratory syncytial virus;response;sample collection;Sampling;SARS-CoV-2 infection;Series;Serum;Silver;Specimen;Sri Lanka;Sterility;Streptococcus pneumoniae;Structure of parenchyma of lung;Subgroup;success;Sweden;Symptoms;System;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Time;tissue resident memory T cell;Tissue Sample;Training;transcriptome;Tuberculosis;unvaccinated;Vaccination;Vaccines;Validation;Viral;Visit;Work;Yellow Fever

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: While successful genome inheritance requires that each gamete – sperm or egg – receives one copy of each chromosome, an estimated 35% of human zygotes contain an incomplete chromosome set, resulting in miscarriages and birth defects. The research proposed here addresses the mechanisms that regulate interaction and information exchange between the parental chromosomes during sexual reproduction, which is essential for correct chromosome segregation into gametes. A better understanding of the structure and dynamics of chromosomes during sexual reproduction will elucidate the mechanistic principles that control chromosomes across biological processes, ranging from gene expression to cell division, and will ultimately shed light on the chromosomal dysfunctions that lead to cancer.

PI_NAMEs: ROG, OFER  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Appearance;Applied Genetics;Biological Process;Cell division;Chromatin;Chromatin Loop;chromosome missegregation;Chromosome Segregation;Chromosome Structures;Chromosomes;Coiled-Coil Domain;Congenital Abnormality;Cytology;DNA;egg;Electron Microscopy;Emerging Technologies;Functional disorder;Gene Expression;Generations;genetic approach;genetic information;Genome;Germ Cells;Human;Infertility;Karyotype;Label;Liquid substance;Malignant Neoplasms;Meiosis;Microscopy;Molecular;Molecular Conformation;Nematoda;novel strategies;Process;Property;protein complex;protein protein interaction;Regulation;Research;Resolution;Role;Saccharomycetales;Sexual Reproduction;single molecule;Sister;Sister Chromatid;sperm cell;Spontaneous abortion;Structure;Synaptonemal Complex;three dimensional structure;Visualization;Work;zygote

PROJECT_TITLE: Large-scale regulation of meiotic chromosome dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

PI_NAMEs: SEUMOIS, GREGORY  (contact)

PROJECT_TERMS: Antibodies;antibody conjugate;antibody detection;Area;ATAC-seq;Biological Assay;Biology;Blood;Cell Count;Cell Physiology;Cell Separation;Cell Surface Proteins;Cells;Chromatin;Collection;COVID-19 vaccination;Data;Data Analyses;data management;Dengue Virus;design;Disease;DNA;DNA Sequencing Facility;Elements;Enhancers;Epigenetic Process;epigenomic profiling;epigenomics;Flow Cytometry;Funding;Future;Gene Expression Profiling;Genes;Genome;genome-wide;genomic platform;Genomics;Guidelines;Health;high throughput analysis;Human;Human Resources;Immune;Immunology;Individual;Infection;insight;interest;Lead;Length;Libraries;lung pathogen;Methodology;Methods;microgenomics;Mission;Molecular Profiling;Mycobacterium tuberculosis;next generation sequencing;novel;pathogen;patient subsets;peripheral blood;Preparation;Procedures;programs;promoter;Protocols documentation;Publications;Reproducibility;Research Personnel;Resolution;respiratory pathogen;RNA;RNA analysis;RNA library;Role;Sampling;SARS-CoV-2 infection;Services;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Site;Small RNA;Sorting;Stains;Standardization;T cell receptor repertoire sequencing;T memory cell;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Tissues;Training;transcription factor;transcription factor USF;transcriptome;transcriptome sequencing;transcriptomics;Tuberculosis;Untranslated RNA;Vaccination

PROJECT_TITLE: Sequencing Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: UNRINE, JASON  (contact)

PROJECT_TERMS: Address;Agriculture;air contaminant;Analytical Chemistry;analytical method;Appalachian Region;base;Biological;Biological Monitoring;Chemicals;Clinical;Coal;college;Communities;community engaged research;community engagement;Core Facility;cost;cost effective;County;Coupled;Data;data management;Data Reporting;detection method;Dioxins;Disease;Disinfection;drinking;Ensure;Environment;environmental chemical;environmental chemistry;Environmental Health;Environmental Pollutants;Environmental Science;environmental toxicology;Exposure to;faculty support;Flame Retardants;Food;Funding;Gas Chromatography;Grant;halogenation;Health;health science research;Health Sciences;High Pressure Liquid Chromatography;Individual;Inductively Coupled Plasma Mass Spectrometry;Industrialization;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Kentucky;Laboratories;laboratory facility;Liquid Chromatography;Literature;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Medicine;member;method development;Methods;Monitor;novel;Office of Administrative Management;operation;Organic Chemicals;Outcome;Particulate Matter;Peripheral;Phenols;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Process;Recovery;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Rural Appalachia;Sampling;Science;Services;small molecule;Strategic vision;Superfund;Survey Methodology;Technical Expertise;Techniques;Technology;toxicant;Trace Elements;translational pipeline;Translational Research;Trihalomethanes;Universities;Validation;Water Pollutants;waterborne;Work

PROJECT_TITLE: Center for Appalachian Research in Environmental Sciences - Analytical Chemistry Core for Environmental Sciences (ACCESS)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Address;Age;antigen-specific T cells;Antigens;Authorization documentation;biomarker panel;Blood specimen;CD8-Positive T-Lymphocytes;Cells;Clinical;Clone Cells;cohort;Common Cold;Communicable Diseases;Coronavirus;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;Cross-Sectional Studies;Cytomegalovirus;Data;Dose;Enrollment;Ethnic Origin;Evaluation;Exposure to;Human;Immune;Immunization;Individual;Infection;Influenza;Investigation;longitudinal analysis;Longitudinal cohort;Measures;Molecular;pathogen;Pathogenicity;Pattern;Persons;Pertussis;Phenotype;pre-pandemic;Property;recruit;respiratory pathogen;Respiratory Tract Diseases;response;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;Sequence Analysis;Severity of illness;sex;single-cell RNA sequencing;T cell clonality;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;Time;transcriptome;transcriptomics;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccine platform;vaccine trial;Vaccinee;Vaccines;Virus;Yellow Fever

PROJECT_TITLE: Longitudinal analysis to determine persistence of T cell responses induced by SARS-CoV-2 vaccination, natural infection with SARS-CoV-2, and human common cold coronaviruses


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: GALVESTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Narrative This project explores a unique non-invasive therapy for traumatic brain injury (TBI). We have compelling evidence demonstrating the neuroprotective effects of a novel nano pulsed optoacoustic laser therapy (NPLT) applied to the injured brain. In the proposed studies, we will use an established pre-clinical model of TBI to evaluate the efficacy of NPLT in mitigating cognitive and neuropathological outcomes when applied in the acute or chronic phase after TBI.

PI_NAMEs: ESENALIEV, RINAT O.;MICCI, MARIA-ADELAIDE  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: absorption;Acute;Affect;Area;Biomedical Engineering;Brain;Brain Injuries;Brain Pathology;brain tissue;Cephalic;chromophore;Chronic;Chronic Phase;Clinic;Clinical;clinical application;Cognition;Cognitive;cognitive change;Cognitive deficits;Data;Development;Diagnostic;disability;effective therapy;efficacy evaluation;Encephalitis;Evaluation;expectation;Eye;fluid percussion injury;Frequencies;global health;Goals;healthcare burden;Hemoglobin;Hippocampus;Hour;Human;Impaired cognition;improved;Inflammation;Injury;Institutional Review Boards;Lasers;Light;Low-Level Laser Therapy;Medical;Memory;Modeling;Monitor;multidisciplinary;nano;nanosecond;Nerve Degeneration;Nervous System Disorder;neural circuit;neural stimulation;Neurocognitive;neurogenesis;neuroinflammation;Neurologic;neuronal circuitry;neuropathology;neuroprotection;neuroregulation;novel;Optics;Outcome;Pathology;Patients;Penetration;Phase;Physicians;Physiologic pulse;pre-clinical;Pre-Clinical Model;preservation;Public Health;Publishing;Rattus;Research;Risk;Skin;Stress;Structure;System;TBI Patients;TBI treatment;Techniques;Technology;Translating;Traumatic Brain Injury;Travel;Treatment Efficacy;ultrasound;Work

PROJECT_TITLE: Nano-Pulsed Optoacoustic Neuromodulation for Reducing Traumatic Brain Injury-Driven Neuropathology and Improving Cognitive Outcome


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative Childhood and adolescence are critical developmental periods during which traumatic experiences can lead to impaired executive function and increased likelihood of psychopathology. While stress related brain aberrations have been widely noted, far less is understood about their developmental trajectory and whether the specific timing of the emergence of stressors may impact long-term function of brain networks related to cognitive function. The proposed work aims to fill this gap by training a promising physician-scientist who will utilize cutting- edge brain mapping methods and longitudinal analytic tools to identify the impact of trauma exposure and HPA axis activation on developmental trajectories of cognitive control in typically developing children and adolescents.

PI_NAMEs: SON, JAKE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 15 year old;Acute;Adolescence;Adolescent;Adult;Affect;Age;analytical tool;Anxiety;Attention deficit hyperactivity disorder;base;Behavioral;Brain;Brain Mapping;Brain region;career;Child;Childhood;childhood adversity;Chronic;Chronology;Clinical;Cognitive;cognitive control;cognitive function;cognitive neuroscience;cognitive testing;Complex;Consensus;critical developmental period;Data;Decision Making;density;Development;Emotional;emotional functioning;epidemiology study;Evaluation;Executive Dysfunction;executive function;Exhibits;experience;Exposure to;Fellowship;Frequencies;Functional disorder;Funding;Goals;Hair;Health;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Image;Impaired cognition;Incidence;insight;Intervention;Investigation;Knowledge;life span;Literature;longitudinal design;Longitudinal Studies;Magnetoencephalography;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Methods;millisecond;neural;neurodevelopment;neuroimaging;Neurologic Process;Neurons;neurophysiology;Neuropsychology;Output;Participant;Patient Self-Report;Performance;Physicians;Prefrontal Cortex;Psychiatry;Psychopathology;reconstruction;Regulation;Reporting;Research;Research Domain Criteria;Research Project Grants;response;Role;Sampling;Scientist;Severities;Source;spatiotemporal;Specificity;Statistical Data Interpretation;Stress;Stressful Event;stressor;Techniques;Time;Training;Trauma;trauma exposure;traumatic event;United States;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Impact of Trauma on the Longitudinal Development of Cognitive Control Networks in Healthy Youth


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PI_NAMEs: PETERS, BJOERN  (contact)

PROJECT_TERMS: Adult;Age;antigen challenge;Antigens;Antitubercular Agents;Bacille Calmette-Guerin vaccination;Biological Assay;biomarker identification;Blood;Blood specimen;Body mass index;Cause of Death;CD4 Positive T Lymphocytes;Cells;Childhood;Clinical;clinical research site;cohort;Collaborations;Communicable Diseases;community transmission;Country;cross reactivity;Cryopreservation;Cytometry;Demographic Impact;Diabetes Mellitus;Disease;effector T cell;Enrollment;Ensure;Epitopes;Eragrostis;Failure;Frequencies;Genetic Transcription;HLA-DR Antigens;Human;Immune;Immune response;Immunologic Memory;Immunologic Stimulation;in vivo;Individual;Infection;Infection Control;Infectious Agent;insight;inter-individual variation;Licensing;longitudinal analysis;Lung;Modeling;Monitor;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Natural Immunity;novel;novel marker;pathogen;Peptides;Peripheral Blood Mononuclear Cell;Peru;Phenotype;Prediction of Response to Therapy;prophylactic;Prophylactic treatment;Publishing;pulmonary agents;Pulmonary Tuberculosis;Resolution;respiratory pathogen;Respiratory Tract Diseases;Risk;Sampling;single cell sequencing;single-cell RNA sequencing;Sorting;South Africa;Specificity;Sri Lanka;Sweden;Symptoms;System;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;Tissues;Treatment outcome;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine-induced immunity;Vaccinee;Vaccines;Whole Blood

PROJECT_TITLE: Longitudinal Analysis of Immune Signatures (IMS) of M. tuberculosis-specific T cells


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Photoreceptors remain viable to perform their essential function throughout a lifetime despite chronic stress and maintaining healthy pools of mitochondria is crucial for photoreceptor health. Investigating mitochondrial movement and quality control mechanisms can yield insight into photoreceptor robustness. I propose using several novel transgenic zebrafish to assess photoreceptor mitophagy and mitochondrial movement.

PI_NAMEs: RUTTER, KAITLYN MICHELLE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Actins;Autophagocytosis;Autophagosome;biological adaptation to stress;Blindness;cell type;Cells;Cessation of life;Chronic stress;cold stress;Color;Cone;Cytoskeleton;Degradation Pathway;experimental study;fluorophore;Health;Hour;Image;Impairment;inhibitor;insight;Label;Larva;Light;Longevity;Lysosomes;LysoTracker;Maintenance;Metabolic;Microtubules;migration;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;model organism;Modeling;Monitor;Movement;Muller's cell;new therapeutic target;novel;Organelles;Photoreceptors;postmitotic;Process;promoter;Quality Control;Radiation;Reactive Oxygen Species;response;Retina;Retinal Cone;Retinal Diseases;retinal neuron;Retinal Photoreceptors;Stress;stressor;Synapses;Testing;therapy development;Time;Transgenic Organisms;Tubulin;Vision;Vision Disorders;Visualization;Zebrafish

PROJECT_TITLE: Understanding mitochondrial movement and turnover in stressed and unstressed photoreceptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;anti-PD1 therapy;anti-tumor immune response;antigen-specific T cells;Aspergillus;ATAC-seq;Atlases;Automobile Driving;Biological Assay;Blood;Bronchoalveolar Lavage;Bronchoscopy;cancer type;Candida;Catalogs;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cells;cellular targeting;Clinical;cohort;Common Cold;Communicable Diseases;Coronavirus;COVID-19 patient;COVID-19 vaccine;Enhancers;epigenome;epigenomics;Epitopes;Excision;flu;Genetic Transcription;Genus Mycobacterium;Goals;Health;Human;Human Characteristics;Hypersensitivity;Immune;Immunology;Infection;Influenza;influenza virus vaccine;insight;Link;Living Donors;Lower respiratory tract structure;Lung;Malignant neoplasm of lung;Malignant Neoplasms;model organism;Molecular;mouse model;Mucous Membrane;Nature;novel;Operative Surgical Procedures;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Peptides;Peripheral Blood Mononuclear Cell;Pertussis;Pertussis Vaccine;Phenotype;Pneumococcal vaccine;Pneumovirus;programs;Property;prospective;recruit;Research;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Diseases;Respiratory Tract Infections;response;Sampling;Science;Severity of illness;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Specificity;Streptococcus pneumoniae;Structure of parenchyma of lung;Subgroup;synergism;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;tissue resident memory T cell;Tissue Sample;transcription factor;transcriptome;transcriptomics;Upper respiratory tract;Vaccinated;Vaccination;vaccine evaluation;vaccine response;Vaccines;Viral;Virus Diseases

PROJECT_TITLE: Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogens


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative Repetitive transcranial magnetic stimulation is emerging as a potential treatment to decrease alcohol craving and consumption. This project will test the effects of repetitive transcranial magnetic stimulation to the medial prefrontal cortex with and without naltrexone on participants’ choices to drink alcohol and on brain neurotransmitter levels in a controlled, hospital-based setting. This application will provide Dr. Wai with the necessary training and expertise to conduct translational research using brain stimulation and magnetic resonance spectroscopy to identify novel treatment approaches and study neurotransmitter response.

PI_NAMEs: WAI, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Adherence;Admission activity;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol seeking behavior;alcohol use disorder;Alcohols;Anterior;Award;binge drinking;Biometry;Brain;Brain region;career;cingulate cortex;Clinic;Clinical;clinical effect;Clinical Research;clinical training;cognitive control;Combination Medication;craving;Data;Decision Making;depressed patient;Development Plans;Devices;Double-Blind Method;drinking;Ethics;FDA approved;Feasibility Studies;Fostering;Frequencies;Functional disorder;Funding;gamma-Aminobutyric Acid;Goals;Grant;Guidelines;Hospitals;Hour;Human;Image;improved;in vivo;Inpatients;Investigation;Israel;K-Series Research Career Programs;Laboratories;Laboratory Study;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Medial;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;neuroimaging;Neurotransmitters;novel;Obsessive-Compulsive Disorder;Outcome Study;Participant;patient oriented research;Physicians;Pilot Projects;Play;Prefrontal Cortex;Procedures;Randomized;reinforcer;repetitive transcranial magnetic stimulation;Reporting;Research;Research Design;Research Methodology;Research Personnel;response;Role;Scanning;Science;Scientist;Self Administration;Severities;Supervision;Symptoms;Testing;Training;Training Programs;Translating;Translational Research;treatment responders;volunteer;Work;Writing

PROJECT_TITLE: The Effect of High Frequency rTMS to the Medial Prefrontal Cortex in Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ROCHESTER

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This program will attract and train a cohort of top graduate students at the interface of chemistry and biology. This training will prepare them for diverse career paths in research and entrepreneurship in the life science, and equip with additional training and experience in teaching and communication of chemistry/biology science. Ultimately, this program will contribute to an improved understanding of human health and new treatments for diseases.

PI_NAMEs: BREN, KARA L.;NILSSON, BRADLEY L. (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemistry;Grant;Training;United States National Institutes of Health

PROJECT_TITLE: NIH Training Grant in Chemistry-Biology Interface

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

PROJECT_TERMS: analysis pipeline;automated analysis;Award;Back;Blood Donations;Cells;central database;Clinical;cohort;Collaborations;Communities;complex data;Computer software;computerized data processing;Cytometry;Data;Data Analyses;data analysis pipeline;Data Coordinating Center;Data Element;data management;Data Management Resources;Data Set;data sharing;data standards;data submission;Database and Analysis Portal;Databases;Dedications;differential expression;Enrollment;Ensure;experience;experimental study;Funding;Gene Expression;Genomics;Goals;Guidelines;high dimensionality;High-Throughput Nucleotide Sequencing;human subject;human subject protection;Immune response;Immunology;improved;Infection;instrument;interest;Internet;large datasets;large scale data;Longitudinal Studies;Manuals;Metadata;Methods;multidimensional data;National Institute of Allergy and Infectious Disease;Patients;Policies;Population;Procedures;Process;programs;public repository;Quality Control;Recommendation;reference genome;Reporting;repository;Reproducibility;Research Project Grants;respiratory pathogen;Sampling;Services;single-cell RNA sequencing;Standardization;Statistical Data Interpretation;success;System;T cell receptor repertoire sequencing;T-Lymphocyte;Target Populations;Time;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Update;user-friendly;Vaccination;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: DIGNAN, MARK B (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Aging;Air;air contaminant;Analytical Chemistry;Appalachian Region;Attention;Back;Bacteria;Catchment Area;Chemicals;Chronic Disease;Chronic Obstructive Pulmonary Disease;Chronically Ill;citizen science;clinical decision-making;Coal;Collaborations;Colorectal Cancer;Communication;Communication Programs;Communities;community academic partnership;community engaged research;community engagement;Community Healthcare;community organizations;community partners;Core Facility;County;Diabetes Mellitus;Disease;Disinfection;Educational Curriculum;Ensure;Environment;Environmental Exposure;Environmental Health;environmental justice;Environmental Risk Factor;Environmental Science;evidence base;Exposure to;Faculty;Floods;Focus Groups;Fostering;Foundations;Funding;Grant;Health;health assessment;health communication;health literacy;Health Personnel;health science research;Health Sciences;Healthcare;hydraulic fracturing;Infrastructure;insight;Institution;investigator training;Kentucky;Knowledge;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;member;Metabolic Diseases;Mining;multimodality;Names;Natural Disasters;novel;Obesity;operation;Particulate Matter;people of color;Pilot Projects;Policies;Policy Maker;Process;programs;Public Health;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk;Rural Appalachia;Science;Scientist;skills;socioeconomic disadvantage;System;toxicant;Training;Translating;translational pipeline;Trust;Universities;Water;Water Pollutants;waterborne;Work

PROJECT_TITLE: Center for Appalachian Research in Environmental Sciences-Community Engagement Core (CEC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Microbial infection of the eye can lead to ulceration, a precursor to blindness. This project works out mechanism(s) by which a natural peptide in human tears is protective against microbial infection by negating previously unappreciated ocular virulence factors. A logical outcome is the development of new therapeutics.

PI_NAMEs: LAURIE, GORDON WILLIAM (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affinity;Affinity Chromatography;Ampicillin;Antibodies;antimicrobial;ATP-Binding Cassette Transporters;Bacterial Model;bactericide;Binding Proteins;Biochemical;Biotinylation;Blindness;Boston;C-terminal;Caenorhabditis elegans;Campylobacter jejuni;Cell Death;cell growth;Cells;Cessation of life;Chelating Agents;Clinical;Collection;commensal bacteria;Complement;Complementary DNA;Cornea;Development;Encapsulated;Escherichia coli;Excision;extracellular;Eye;Eye Infections;Francisella tularensis;Genetic;Genetic Screening;Goals;Helicobacter pylori;Human;Individual;Infection;inhibitor;Iron;Knock-out;knockout gene;Legionella pneumophila;Mass Spectrum Analysis;Massachusetts;Mediating;Mediator;Membrane;Membrane Proteins;metabolomics;microbial;microbicide;Mitogens;mouse model;mutant;Mutate;Names;novel therapeutics;nuclease;ocular surface;opportunistic pathogen;Outcome;Parents;pathogen;Peptides;periplasm;Polyamines;Pseudomonas aeruginosa;Putrescine;Reflex action;Regulation;Resistance;resistant strain;respiratory;Role;solute;Source;Spermidine;Staphylococcus aureus;Staphylococcus epidermidis;Supplementation;Surface;Surface Plasmon Resonance;syndecan;synthetic peptide;System;tear proteins;Testing;Ulcer;Universities;uptake;Uropathogenic E. coli;Virginia;Virulence;Virulence Factors;Work

PROJECT_TITLE: Tear Protein Microbial Regulation


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: This year an estimated quarter million American men will be diagnosed with prostate cancer (PCa) including 14,000 men in the Veterans Health Administration (VHA). Men with localized PCa are often treated with surgery, a treatment that is associated with high rates of side effects such as erectile dysfunction (ED) and urinary incontinence (UI) which impact quality of life. Yoga may improve control of UI and improve ED by bringing awareness to and strengthening the pelvic floor musculature. The objective of the proposed randomized controlled pilot study is to assess the feasibility of an innovative hybrid (in-person and virtual) twice-weekly yoga program that includes a prehabilitation component and to obtain preliminary data that will help assess its potential effectiveness in alleviating PCa treatment symptom burden (primarily ED and UI). The long-term goal is to develop a scalable and sustainable yoga program that helps VHA cancer survivors manage their treatment side effects.

PI_NAMEs: SILVA, ABIGAIL  (contact)

PROJECT_TERMS: Address;Age;American;Anxiety;Awareness;Bladder Control;Blood flow;cancer care;cancer diagnosis;Cancer Fatigue;Cancer Patient;Cancer Survivor;cancer therapy;Caring;cohort;comorbidity;Complementary Health;Data;Diagnosis;effective intervention;Effectiveness;Effectiveness of Interventions;efficacy evaluation;Erectile dysfunction;experience;Fatigue;Financial Hardship;follow-up;Goals;Habilitation;Health;Health Services Research;Healthcare Systems;Hybrids;Iatrogenesis;improved;innovation;Integrative Medicine;Intervention;Length;Life Style Modification;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Meditation;men;Mental Depression;Mental Health;Methodology;Mind-Body Intervention;Modality;Modeling;Monitor;Operative Surgical Procedures;Outcome;Pain;patient population;Patients;Pelvic Floor Muscle;Pelvic floor structure;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;Population;post intervention;primary outcome;Program Development;programs;prostate cancer survivors;Prostate Cancer therapy;Prostatectomy;Quality of life;Radical Prostatectomy;Randomized;reduce symptoms;Reporting;Research;Safety;Schedule;secondary outcome;Self Management;side effect;standard of care;Stress;Surveys;Symptom Burden;symptom management;symptomatic improvement;targeted treatment;Transportation;Travel;Treatment Efficacy;Treatment Side Effects;uptake;Urinary Incontinence;Veterans;Veterans Health Administration;virtual;Visit;whole health;Woman;Work;Yoga

PROJECT_TITLE: Developing and Pilot-testing a Yoga Program to Address Post-prostatectomy Side-effects Among Veterans with Prostate Cancer

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  This competitive renewal RO1 application aims to further dissect the mechanisms by which hydrogen sulfide, a novel uterine artery dilator we pioneered the last funding cycle, utilizes to mediate estrogen- induced uterine vasodilatation in normal pregnancy and how these mechanisms are impaired in preeclampsia. New data obtained will enhance the cellular and molecular understanding of estrogens, ion channels, uterine artery vascular smooth muscle contractility and tone, and uterine blood flow. The knowledge will in turn inform new pathways to assist the development of therapeutics for combating preeclampsia and other pregnancy failures and will also shed lights on the understanding of the cardiovascular protective effects of estrogens.

PI_NAMEs: CHEN, DONGBAO  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Arteries;Bathing;Biochemical;Biological Process;Biology;Blood flow;Blood Vessels;Cardiovascular system;Cell Separation;Closure by clamp;Complex;Cystathionine;Cystathionine beta-Synthase;Cysteine;Cysteine Desulfhydrase;Data;Development;Dilator;druggable target;Electrophysiology (science);Endothelial Cells;Endothelium;Enzymes;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Funding;Genetic;Genetic Transcription;Grant;hemodynamics;Human;Hydrogen Sulfide;Hysterectomy;Impairment;In Vitro;in vivo;Ion Channel;Knock-out;Knowledge;Mediating;Mesentery;Messenger RNA;Modeling;Molecular;Mus;mutant;Myometrial;Nitric Oxide;NOS3 gene;novel;Organ;Oxidation-Reduction;Oxides;Pathway interactions;persulfides;pharmacologic;Physiological;Pilot Projects;Play;Potassium;Potassium Channel;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy failure;pregnant;pressure;Primary Cell Cultures;Production;protective effect;Proteins;Proteomics;Rattus;Regulation;Relaxation;Reporting;Research;Role;Route;Sampling;Shapes;Signal Transduction;Site;Smooth Muscle;Smooth Muscle Myocytes;sulfhydration;Sulfhydryl Compounds;System;Testing;Therapeutic;therapeutic development;Up-Regulation;Uterus;Vascular Smooth Muscle;Vasodilation;Vasodilator Agents;voltage;Voltage-Gated Potassium Channel;Woman;Work

PROJECT_TITLE: Actions of Estrogen on Uterine Artery Endothelium

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). The proposed 4-year RCT will compare outcomes of ERP to those of a stress management control among Veterans with OCD. Primary and secondary aims will examine whether Veterans’ functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings. This work addresses RR&D clinical priorities related to cognitive-behavioral interventions for improving Veterans’ functioning, participation in society, and quality of life.

PI_NAMEs: FLETCHER, TERRI LYNN (contact);HUNDT, NATALIE E

PROJECT_TERMS: Address;Administrator;Adoption;Affect;Aftercare;Anxiety;Caring;Case Study;Child;Child Care;Chronic;Clinical;Clinical Trials;clinically significant;Cognitive Therapy;Communities;comorbidity;Complex;Compulsive Behavior;coping;Data;Distress;Educational Intervention;effective therapy;Effectiveness;effectiveness evaluation;Eligibility Determination;Ensure;evidence base;Evidence based treatment;Exercise;experience;Exposure to;Face;Family;follow up assessment;formative assessment;functional improvement;future implementation;habituation;Home;Home environment;Hospitals;Illness impact;implementation evaluation;implementation outcomes;improved;Individual;Intervention;Interview;Knowledge;Learning;Life;Logistics;Mental disorders;Mental Health;Meta-Analysis;Methods;military veteran;Obsession;Obsessive-Compulsive Disorder;Outcome;Participant;Patient Self-Report;Perception;Persons;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prevention;Prevention trial;Provider;Psychotherapy;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;recruit;Research;response;Sampling;satisfaction;Schizophrenia;Severities;Site;social;Societies;stress management;Suicide attempt;Symptoms;telehealth;Testing;Training;Transportation;Trauma;Veterans;Veterans Health Administration;Work;Workplace

PROJECT_TITLE: Exposure and Response Prevention to Improve Functioning in Veterans with Obsessive Compulsive Disorder

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The majority of children and adults with dermatomyositis (DM) still experience long-term functional impairment with modern treatments. Drug repositioning is an untapped opportunity to identify existing treatments that work in a precise manner for complex autoimmune diseases, like DM. Using a combination of single-cell RNA sequencing, computational drug repurposing, and ex-vivo cell culture assays, we will identify existing compounds that perturb DM-associated molecular networks in DM-associated cell types with the long-term goal of improving health outcomes through the identification of precision medicine treatments.

PI_NAMEs: NEELY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Advisory Committees;Affect;Aftercare;Animal Model;Antigen-Antibody Complex;Area;Autoantibodies;Autoimmune Diseases;Award;B-Lymphocytes;Bioinformatics;Biological Assay;California;career;career development;Caring;CD14 gene;CD28 gene;CD3 Antigens;CD8B1 gene;Cell Culture Techniques;cell type;Cells;Child;Child Care;Childhood;clinical remission;Clinical Trials;Combined Modality Therapy;Complex;cost;Cytometry;Data;Dedications;Dermatomyositis;Development Plans;Disease;Disease Outcome;Dose;drug development;drug repurposing;efficacious treatment;Environment;experience;Faculty;FCGR3B gene;Functional impairment;Genetic;Goals;Health;Human;Immune;immune activation;Immune response;Immunologist;Immunology;immunopathology;improved;Institution;interest;Interferon Type I;Juvenile Dermatomyositis;Knowledge;Label;Macrophage;Maps;Measures;Mediating;Memory B-Lymphocyte;Mentors;Mentorship;Methods;Modernization;Molecular;molecular sequence database;monocyte;Morbidity - disease rate;mortality;Muscle;Natural Killer Cells;novel;Outcome;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;personalized care;Persons;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;pre-clinical;precision medicine;Precision therapeutics;PTPRC gene;Publications;Rare Diseases;Refractory;Regulatory T-Lymphocyte;Research;response;Rheumatism;rheumatologist;Rheumatology;San Francisco;Scientist;single cell analysis;single-cell RNA sequencing;skills;Skin;skin disorder;Steroids;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Time;Tissues;Training;transcriptome sequencing;transcriptomics;translational immunology;Translational Research;translational scientist;Universities;Work

PROJECT_TITLE: Harnessing single cell RNA sequencing and integrative bioinformatics to identify precision therapeutics for dermatomyositis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PI_NAMEs: CURRY, THOMAS E (contact)

PROJECT_TERMS: Address;Air;Appalachian Region;Award;Categories;Clinical;clinical center;Clinical Sciences;Collaborations;Communication;Communities;community academic partnership;community building;community engaged research;community organizations;Core Facility;Creativeness;Data;design;Development;Dimensions;Discipline;Disease;electronic data;Emerging Technologies;Ensure;Environmental Exposure;Environmental Health;Environmental Science;Evaluation;experience;Exposure to;Faculty;Fostering;Funding;Funding Opportunities;Goals;Grant;Health Sciences;high risk;Human Biology;IACUC;improved;innovation;Institution;Institutional Review Boards;Investigation;Kentucky;Lead;Leadership;Legal patent;Manuscripts;meetings;member;Monitor;multidisciplinary;new technology;next generation;novel;Pathway interactions;Pilot Projects;population based;pre-clinical;programs;Publishing;Research;Research Personnel;research study;Resources;Rural Appalachia;Science;Scientist;Strategic vision;success;synergism;Time;translational pipeline;Translational Research;United States National Institutes of Health;Universities;Water;Work

PROJECT_TITLE: Center for Appalachian Research in Environmental Sciences-Pilot Project Program (PPP)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Precision Medicine;Radiation Oncology;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Proposed is a novel, non-invasive, laser and ultrasound based imaging technology, namely photoacoustic chemical imaging or PACI, that can map the key chemical properties of the tumor microenvironment in vivo, guiding healthcare providers on what would be the best option for treating the cancer patient, e.g., radio-, chemo-, or immuno-therapy. In this research, PACI powered by chemical nanosensors will be used to study the correlations of the imaged tumor’s chemical compositions with the cancer’s responses to therapy, based on mouse models of specific patient-derived breast cancer tumors.

PI_NAMEs: KLEER, CELINA G;WANG, XUEDING  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acidosis;Affect;Aftercare;Animal Model;cancer imaging;cancer immunotherapy;Cancer Patient;cancer therapy;chemical property;Chemicals;chemotherapy;Clinical Management;clinical translation;Complex;Correlation Studies;Early identification;Early treatment;Ecosystem;Ensure;experience;Funding;Health Personnel;hyperkalemia;Hypoxia;Image;image guided;Imaging technology;Immunotherapy;in vivo;Individual;Invaded;Lasers;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Medicine;member;Metabolic;Modeling;Modification;Molecular Biology;mouse model;Mus;nanomedicine;nanoprobe;nanosensors;Neoplasm Metastasis;novel;optimal treatments;Outcomes Research;Oxygen;patient derived xenograft model;Patient imaging;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Patients;Penetration;personalized cancer therapy;Pharmaceutical Preparations;photoacoustic imaging;Physiological;Play;Potassium;Prediction of Response to Therapy;Publications;Radiation therapy;Radio;Research;Resistance;Resolution;response;Shapes;Signal Transduction;Solid Neoplasm;Spatial Distribution;spatiotemporal;Speed;System;T cell therapy;Technology;Testing;Tissues;tool;Translational Research;Treatment outcome;treatment planning;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumor xenograft;ultrasound;Warburg Effect

PROJECT_TITLE: Personalized Cancer Therapy Guided by Photoacoustic Chemical Imaging (PACI) of Tumor Microenvironment (TME)


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The purpose of this renewal is to provide intensive short-term research training for 24 selected pre-doctoral medical students in the most outstanding laboratories and training sites at the Yale School of Medicine. The specific research experiences will range from fundamental molecular biology and cellular physiology to applied clinical studies in heart, lung, blood, and sleep (HLBS) related diseases. The program is designed to attract the most highly qualified Yale medical students into careers as physician-scientists in the biomedical sciences.

PI_NAMEs: CHAUDHRY, SARWAT I (contact);HERZOG, ERICA L

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Achievement;Appointment;Area;Blood;career;Cell Physiology;Clinical;Clinical Research;design;Education;Educational Curriculum;Ensure;Environment;experience;Faculty;First Independent Research Support and Transition Awards;follow-up;Funding;Goals;Grant;Health Professional;Heart;Instruction;interest;Laboratories;Lung;medical schools;Medical Students;Medicine;member;Mentors;Mission;Molecular and Cellular Biology;National Heart, Lung, and Blood Institute;Performance;Physicians;pre-doctoral;Productivity;programs;Qualifying;Research;Research Infrastructure;Research Project Grants;Research Support;Research Training;Schools;Science;Scientist;Site;Sleep;Students;success;Talents;Training;Training Programs;Training Support;United States National Institutes of Health;Writing

PROJECT_TITLE: Short Term Research Training:  Students in Health Professional Schools


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Metabolic diseases, including obesity and diabetes, are rampant in the United States and across the world. Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of fat cell biology and the target of anti-diabetic drugs that uniquely reverse insulin resistance but have serious side effects, while glucocorticoid receptor (GR) is the target of steroids that are used to treat inflammatory conditions, but cause obesity, diabetes, and lipid disorders. Our innovative genome-wide and systems approaches will provide fundamental insight into molecular mechanisms underlying tissue- and individual-specific effects of PPARγ and GR, guiding new therapies and predictions of patient-specific metabolic responses to commonly prescribed drugs.

PI_NAMEs: LAZAR, MITCHELL A. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;adipocyte biology;Adipocytes;adipose derived stem cell;Adipose tissue;Adverse effects;Anti-diabetic Drugs;Anti-Inflammatory Agents;Binding;Biological Assay;Biology;Cell Physiology;Cells;Cellular biology;ChIP-seq;Clinical;clinical effect;clinical predictors;comparative;Data;Diabetes Mellitus;diabetes mellitus therapy;Diet;Dissection;Drug Prescriptions;Drug Targeting;epigenomics;Epitopes;fighting;Functional disorder;functional genomics;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Genotype;Glucocorticoid Receptor;Glucocorticoids;Goals;Hepatocyte;Human;human stem cell-derived;human stem cells;Individual;Individual Differences;individual response;Inflammation;Inflammatory;innovation;insight;Insulin;Insulin Resistance;Knowledge;Laboratories;Ligands;lipid disorder;Liver;Macrophage;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Modernization;Molecular;mouse model;Mus;novel;novel therapeutics;Nuclear Receptors;Obese Mice;Obesity;Obesity Epidemic;obesogenic;patient population;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;PPAR gamma;PPARgamma2;Protein Analysis;Protein Isoforms;receptor binding;receptor function;Regulation;response;risk variant;Role;side effect;Single Nucleotide Polymorphism;Site;Societies;stem cell model;stem cells;Steroids;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Thiazolidinediones;Tissues;transcriptome sequencing;transcriptomics;United States

PROJECT_TITLE: Nuclear Receptors in Metabolic Tissues

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Heart attacks–a major cause of death–are most commonly caused by coronary artery disease. While there are powerful imaging methods to detect coronary disease by PET (looking at blood flow in heart and inflammation in the arteries) or CT (depicting anatomy and calcium deposits in the artery), physicians are not able to use these data effectively to identify patients at the highest risk of adverse events— due to complexity and lack of automation. The investigator proposes to establish a large multicenter PET and CT imaging registry and with artificial intelligence tools, automate analysis and quality control, and develop decision support tools utilizing collectively all available PET/CT images and clinical information (beyond what is possible by subjective visual analysis and mental integration) for identification of patients with high-risk disease who can benefit from treatment with aggressive therapies—while providing patient-specific explanations of the risk factors.

PI_NAMEs: SLOMKA, PIOTR J (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: adverse event risk;aggressive therapy;Anatomy;Arteries;Artificial Intelligence;artificial intelligence method;Atherosclerosis;automated analysis;Automation;Blood flow;Calcium;Cardiometabolic Disease;Cardiovascular system;Cause of Death;Chronic Kidney Failure;Clinical;Clinical Data;Coronary Arteriosclerosis;coronary artery calcium;Coronary heart disease;Data;Deposition;Detection;Diabetes Mellitus;Disease;disorder risk;experience;Functional disorder;Functional Imaging;Heart;High Prevalence;high risk;high risk population;Image;Image Analysis;imaging modality;improved;Inflammation;Measures;Modality;molecular imaging;Multimodal Imaging;Myocardial;Myocardial Infarction;Myocardial Ischemia;non-invasive imaging;novel;obese patients;outcome prediction;Patients;Physicians;Population;Positron-Emission Tomography;programs;Psyche structure;Public Health;Quality Control;Recommendation;Registries;Relative Risks;Research;Research Personnel;Risk;Risk Estimate;Risk Factors;structural imaging;support tools;Techniques;tool;Vision;Visual;Work

PROJECT_TITLE: Patient-specific Outcome Prediction from Cardiovascular Multimodality Imaging by Artificial Intelligence


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Patient Safety;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PUBLIC HEALTH RELEVANCE Rural US residents are at high risk for food insecurity and type 2 diabetes (T2DM).6,7 Recent studies have shown promise for improving health indicators for food insecure people with T2DM by distributing healthy food,22-24,29 but these interventions have not been tested in the rural populations who may benefit from the interventions the most. This study's objective is to determine whether a scalable, sustainable home food delivery intervention that is designed with rural food insecure patients with T2DM in mind can improve their health and diet quality.

PI_NAMEs: MCELFISH, PEARL  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Age;Area;arm;Blood Pressure;Body mass index;cardiometabolic risk;care costs;Clinic;comparative cost effectiveness;comparative effectiveness;compare effectiveness;compliance behavior;Complications of Diabetes Mellitus;Consumption;cost;cost effective;cost effectiveness;Data;design;diabetes distress;diabetes management;Diabetes Mellitus;Diet;Distress;economic disparity;Educational Materials;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Ethnic Origin;evidence base;experience;Fasting;fasting glucose;follow-up;Food;food insecurity;food security;fruits and vegetables;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Health;health disparity;health equity;Health Food;Healthy Eating;Heterogeneity;high risk;Home;Household;improved;improved outcome;indexing;Intervention;intervention delivery;Knowledge;Lipids;Measures;medication compliance;metropolitan;Mind;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Participant;Patient Compliance;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;post intervention;Prevalence;Probability;public health relevance;Quality of life;Quality-Adjusted Life Years;Race;Randomized;Recipe;Recommendation;recruit;Research;Risk;Risk Factors;Rural;rural area;Rural Community;rural dwellers;rural environment;rural health clinic;rural patients;Rural Population;rural setting;Secure;Self Efficacy;Self Management;Severities;sex;standard care;success;Testing;Time;treatment effect;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Home Food Delivery for Diabetes Management in Patients of Rural Clinics


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Insomnia affects an alarming number of Veterans with psychotic disorders; and is a major contributor to poor functioning, high distress, and unrealized rehabilitation and recovery. I have developed guidelines to assist providers in clinically tailoring the gold standard intervention for insomnia–Cognitive Behavioral Therapy for Insomnia (CBT-I)–so that it meets the unique needs of Veterans living with psychosis. This study will evaluate whether CBT-I delivered using these guidelines improves both sleep and functioning in Veterans living with psychosis and insomnia. This project will also examine the extent to which improvements in insomnia are associated with longer-term functional benefits. If CBT-I delivered in line with these guidelines is effective, the guidelines can be integrated into the existing national VA CBT-I trainings, manual, and online treatments to enhance the rehabilitation of this highly affected yet underserved Veteran population.

PI_NAMEs: KLINGAMAN, ELIZABETH A (contact)

PROJECT_TERMS: Acceleration;actigraphy;active control;Address;Affect;Aftercare;Area;Behavioral;Caring;Chronic;Chronic Insomnia;Cladribine;Clinical;clinical practice;Cognitive;cognitive function;cognitive recovery;Cognitive Therapy;Complex;Consensus;cost;daily functioning;Data;Development;disability;Distress;Effectiveness;efficacy evaluation;Emotional;emotional functioning;evidence base;experience;Feedback;follow up assessment;follow-up;Functional impairment;functional improvement;functional outcomes;Funding;Guidelines;handbook;health related quality of life;Health Services Accessibility;Health Surveys;Healthcare;Healthcare Systems;Impairment;improved;improved outcome;improvement on sleep;indexing;Inequity;Internet;Intervention;Letters;lifetime risk;Manuals;Maryland;Mediating;Mediation;Medical;Medical center;Mental disorders;Mental Health;Mental Health Services;Methods;military veteran;Modeling;Outcome;Outcome Measure;Participant;Persons;Pharmaceutical Preparations;Philadelphia;physical conditioning;Population;primary outcome;Process;Provider;psychiatric symptom;Psychoses;psychosocial;Psychotherapy;Psychotic Disorders;psychotic symptoms;Quality of life;Randomized, Controlled Trials;Recovery;Recovery of Function;Rehabilitation therapy;Reporting;Research;Research Priority;Research Support;Resolution;Resources;secondary outcome;severe mental illness;Severities;Severity of illness;side effect;Site;Sleep;Sleep disturbances;Sleeplessness;Social Functioning;standard care;standard of care;Suicide attempt;Symptoms;System;Testing;Training;Translating;treatment effect;trial comparing;Veterans;Veterans Health Administration;Visit;Work;World Health Organization Disability Assessment Schedule;Wrist

PROJECT_TITLE: Cognitive Behavioral Therapy For Insomnia (CBT-I) to Improve Functional Outcomes in Veterans with Psychosis

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Diabetic peripheral neuropathy (DPN) is a major complication of diabetes affecting about 50% of the veteran population. The symptoms range from pain, numbness, paresthesia and ulceration in the extremities it is also the major cause of non-traumatic amputations. The only option physicians have to slow progression of DPN is glycemic control but in type 2 diabetes, the most prevalent form in the veteran population, good glycemic control is ineffective. There is a desperate need for an effective treatment. Our pre-clinical studies have demonstrated that increasing the dietary intake of omega-3 polyunsaturated fatty acids (PUFA), commonly found in fish oil, slows the progression of DPN and induces nerve repair through reducing inflammatory stress and increasing the production of resolvins, neuroprotectin and maresins, metabolites of the omega-3 PUFA eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA). However, it is unknown what the most effective form or source is for omega-3 PUFA and that question will be investigated in this application.

PI_NAMEs: YOREK, MARK A. (contact)

PROJECT_TERMS: Acids;Address;Adverse effects;Affect;Afferent Neurons;Algae;Amputation;Anti-Inflammatory Agents;Behavioral;Blindness;blood glucose regulation;Blood Vessels;Brain;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Caring;Cholesterol;Chronic;Chronic Disease;Circulation;Clinical Trials;Complex;Complications of Diabetes Mellitus;Consumption;Cornea;density;design;Diabetes Mellitus;diabetic;diabetic rat;Dietary intake;Disease;Docosahexaenoic Acids;Dose;effective therapy;efficacious treatment;Eicosapentaenoic Acid;End stage renal failure;Equilibrium;Erythrocytes;Esters;Etiology;Event;falls;Fatty Acids;Fish Oils;Fishes;Friends;Functional disorder;glycemic control;Goals;Greenland;Health Care Costs;Healthcare;Heart;Heavy Metals;High Density Lipoproteins;human subject;Hypertriglyceridemia;improved;in vivo;indexing;Industrialization;Inflammatory;Insulin-Dependent Diabetes Mellitus;Inuits;Ischemia;Limb structure;Measures;Menhaden oil;military veteran;Modeling;Molecular Target;mortality risk;Motor;Nerve;nerve damage;Nerve Regeneration;nerve repair;neural;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Numbness;Obesity;Oils;Omega-3 Fatty Acids;Outcome;Overweight;Pain;Paresthesia;Pathologic;Pathway interactions;patient population;Patients;Peripheral Nervous System Diseases;Pharmacologic Substance;Physicians;Population;preclinical study;Prediabetes syndrome;Production;Property;Quality of life;Rattus;repaired;Research;Risk;Risk Factors;Rodent;Series;Serum;Skin;Source;Stress;Sum;Symptoms;Therapeutic;Type 2 diabetic;Ulcer;United States;Veterans

PROJECT_TITLE: Omega-3 Polyunsaturated Fatty Acids in the Treatment of Diabetic Peripheral Neuropathy:Is the source important?

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: Spinal cord injury (SCI) is a medically complex disability that poses unique barriers to employment for Veterans. Returning to work after SCI improves health and quality of life, which in turn can lower risk for suicide in this high-risk population. Hence, the Department of Veterans Affairs (VA) supports interventions that help Veterans with SCI return to work and prevent suicide. Customized employment (CE) is an innovative strategy for tailoring vocational services to meet the needs of people with complex disabilities. To address barriers to employment faced by Veterans with SCI, CE can be adapted for use by the VA as a part of SCI medical rehabilitation. The research goal is to evaluate a CE intervention for Veterans with SCI (ACCESS-Vets) to help them discover their strengths and find and maintain competitive integrated employment in their communities. This study may provide a model for making VA vocational services for Veterans with SCI more effective and sustainable.

PI_NAMEs: OTTOMANELLI, LISA  (contact)

PROJECT_TERMS: Address;Adoption;Adult;Area;Caregivers;Caring;Charge;Clinical;clinical care;clinical practice;Clinical Services;Communities;community reintegration;Complement;Complex;Data;Data Collection;Development;disability;effectiveness evaluation;Employment;Employment-Based Services;empowerment;Evaluation;evidence base;Evolution;experience;Face;Florida;functional improvement;Goals;Health;Health Services Administration;high risk population;improved;Individual;innovation;Intervention;Job Satisfaction;Life;Link;Longevity;Measures;Medical;Mental Health;Methods;Modeling;Modernization;Occupations;Outcome;Participant;Personal Satisfaction;Persons;physical conditioning;physically handicapped;Policies;Population;population based;preventive intervention;primary outcome;Process;programs;Provider;psychological outcomes;Quality of life;randomized, clinical trials;Recommendation;rehabilitation service;Rehabilitation therapy;Reporting;Research;Role;Sampling;secondary outcome;Services;Site;social inclusion;Social outcome;Specialist;Spinal cord injury;Standardization;suicidal risk;Suicide prevention;Supported Employment;Target Populations;Telephone Interviews;Testing;therapy design;Time;Training;treatment as usual;Unemployment;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Virginia;Vocation;Vocational rehabilitation;Wages;Work

PROJECT_TITLE: Achieving Competitive Customized Employment through Specialized Services - Veterans: ACCESS-VETS


FUNDING_MECHANISM: OTHERS

ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: Veteran suicide has been an increasingly concerning issue. Suicide prevention is a top priority for VA as we continue to seek new and inventive ways to reduce suicide rates among Veterans. Many experts agree that suicide prevention efforts could be improved by making suicide-specific interventions easier to access. The current project aims to move toward that goal by testing a web-based suicide prevention intervention using an experimental design. The 30-minute intervention aims to teach Veterans coping skills that are designed to ease the emotional distress that often comes with thoughts of suicide. The project will evaluate whether Veterans report more improvement in suicidal ideation severity when this intervention is added to their normal course of treatment. Findings will aid our understanding of whether these types of interventions would be helpful to give to thousands of Veterans who suffer with suicidal thoughts – particularly if we can make it more accessible in non- therapy settings like primary care clinics, emergency departments, or from home as a mobile application.

PI_NAMEs: BOFFA, JOSEPH WILLIAM (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adopted;Age;Agreement;Area;arm;Award;Behavior;Caring;Clinic;Clinical;Clinical Investigator;Clinical Trials;comparison control;comparison intervention;Confidence Intervals;coping;Coping Skills;design;Development;Distress;Educational process of instructing;Effectiveness;effectiveness evaluation;efficacy evaluation;Emergency Situation;emotional distress;Ensure;Evaluation;evidence base;Evidence based intervention;Experimental Designs;Feeling suicidal;follow-up;Goals;Health;health care settings;Home;improved;indexing;Individual;innovation;Intervention;Interview;Measures;Mediating;Mental Depression;Mental Health;Mental Health Services;mHealth;mobile application;novel;Online Systems;Outpatients;Patient Self-Report;Positioning Attribute;Preparation;prevent;Prevention;Prevention Research;preventive intervention;Primary Care;primary care clinic;Principal Investigator;programs;psychologic;Psychotherapy;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Research;Research Personnel;Research Project Grants;response;Sampling;Self Direction;Severities;sex;skills;Structure;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Syndrome;Technology;Testing;Therapeutic;therapy design;Training;Training Activity;training data;treatment as usual;United States;United States Department of Veterans Affairs;Veterans;Violence;web-based intervention

PROJECT_TITLE: Effects of a Targeted Web-Based Suicide Prevention Intervention on Suicidal Ideation and Self-Directed Violence: A Randomized Controlled Trial in Veterans


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis, spinal cord injury or stoke. In supervised research sessions, iBCI technology has enabled individuals with severe paralysis to use computers by imagining their own hand movements to control point-and-click actions for on-screen typing, browsing the web and other familiar enabling activities. In this project, we enhance deep learning neural network decoders and multi-state gesture decoding for increased accuracy and reliability and deploy them on a battery-powered mobile BCI device for independent use of computers and touch-enabled mobile devices at home.

PI_NAMEs: SIMERAL, JOHN DAVID (contact)

PROJECT_TERMS: Address;Adoption;Algorithms;Amyotrophic Lateral Sclerosis;arm;Artificial Arm;assistive robot;autoencoder;brain computer interface;Calibration;Classification;Clinical;Communication;comparison control;Computer software;Computers;Data;Data Science;deep learning;deep neural network;Development;Devices;dimension reduction;Dimensions;Disabled Persons;Electric Stimulation;Evaluation;Exhibits;feature extraction;finger movement;Fingers;Gestures;Goals;grasp;Hand;handheld mobile device;high dimensionality;Home;Human;Imagery;Implanted Electrodes;improved;Individual;innovation;interest;Internet;Intuition;kinematics;Limb structure;Link;long short term memory;Machine Learning;Maps;markov model;Methods;mobile application;Motor Cortex;Motor disability;Movement;Mus;Muscle;neural;Neurofibrillary Tangles;neurotransmission;Non-linear Models;Outcome;Output;Paralysed;Participant;Pattern;Performance;Persons;phrases;Precentral gyrus;preclinical study;Process;prototype;Quadriplegia;recurrent neural network;recursive neural network;Reporting;Research;Running;Sampling;Self-Help Devices;Signal Transduction;simulation;Speech;Speed;Spinal cord injury;Stream;Stroke;Tablets;Techniques;Technology;Text;theories;Time;Touch sensation;Translating;two-dimensional;Upper Extremity;User-Computer Interface;Veterans;virtual;Wheelchairs;wireless

PROJECT_TITLE: Enhancement and optimization of a mobile iBCI for Veterans with paralysis

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


PHR: This project will determine whether a specific type of deep-learning approach to artificial intelligence, utilizing deep variational autoencoders (VAEs), is as sensitive as a glaucoma expert for assessing glaucoma progression, will predict future image-based representations of structure and function in eyes with glaucoma, and will provide better correlation with quality-of-life outcome measures than with clinical data currently used. If so, incorporation of VAEs into clinical practice will lead to better diagnostic capability, earlier treatment intervention, and better visual and quality-of life outcomes in our veterans suffering from glaucoma.

PI_NAMEs: GARVIN, MONA K. (contact);KARDON, RANDY H.

PROJECT_TERMS: Affect;aggressive therapy;Ambulatory Care Facilities;Area;Artificial Intelligence;autoencoder;Back;Binocular Vision;Blindness;Clinic;Clinical;Clinical Data;clinical practice;Communities;Computers;Data;deep learning;Defect;denoising;diagnostic value;Disease;Early Diagnosis;Early treatment;expectation;experience;Eye;field study;Future;ganglion cell;Ganglion Cell Layer;Glaucoma;Global Change;Goals;Image;Individual;Inner Plexiform Layer;instrument;interest;Intervention;Learning;macula;Maps;Measures;Methods;Modeling;Monitor;Morphology;novel;novel strategies;optic cup;Optic Disk;Optic Nerve;Optical Coherence Tomography;optical disc;Outcome;Outcome Measure;Output;Patients;Pattern;preservation;Quality of life;Reporting;Retina;retinal nerve fiber layer;Series;Severities;Standardization;Structure;success;Testing;Thick;Time;Training;treatment planning;trend analysis;Veterans;Vision;Visual;Visual Fields;visual map;Visuospatial

PROJECT_TITLE: Early Detection of Progressive Visual Loss in Glaucoma Using Deep Learning

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Nearly 90% of people with Parkinson's disease have speech and voice disorders that negatively impact their ability to communicate effectively in daily life. This study will test the hypothesis that a combined speech and exercise intervention will improve speech intelligibility in people with Parkinson's disease and speech impairment. This approach would offer an affordable way to continue to both instruct and encourage training by veterans virtually indefinitely through our remote access technology. These findings may help VA clinicians provide optimal care for the many veterans with Parkinson's disease and speech impairment.

PI_NAMEs: SPARROW, DAVID W. (contact)

PROJECT_TERMS: Acoustics;Articulation;Caring;Communication;Communities;Control Groups;design;Dysarthria;Effectiveness;exercise intervention;Future;Goals;Grant;Health education;Home;Impairment;improved;indexing;Individual;Intervention;intervention effect;intervention program;Lead;Life;Loudness;Measures;Mediating;Mediator;Methods;motor symptom;Nature;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Patients;Performance;Persons;pharmacologic;Phonation;programs;Quality of life;Randomized;Randomized, Controlled Trials;response;Severities;Speech;Speech Acoustics;Speech Disorders;Speech Intelligibility;Technology;Telemedicine;Testing;Time;Training;Variant;Veterans;virtual;Voice;Voice Disorders;Voice Quality

PROJECT_TITLE: An RCT of a telemedicine intervention for hypokinetic dysarthria in PD


PHR: PROJECT NARRATIVE The UCSF Postdoctoral Training Program in Hepatology is designed to provide MD and PhD scientists the skills to conduct independent research relevant to the liver. The Program fills a need for basic and clinical investigators who will develop new knowledge to aid the prevention, diagnosis and treatment of liver-related ailments. The Training Program enables faculty to provide focused research instruction to 4 trainees per year. Importantly, it also enables trainees to enroll in didactic courses and obtain an advanced degree. The ultimate goal of the Training Program is for graduates to become independent investigators, meaningful contributors to the field of hepatology, and mentors themselves. The expectation is that the trainees’ research successes will translate into improved outcomes for patients suffering from liver diseases.

PI_NAMEs: KHALILI, MANDANA ;MAHER, JACQUELYN J. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Grant;Hepatology;National Research Service Awards;Training

PROJECT_TITLE: NRSA Hepatology Training Grant


ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative There is a nationally recognized need to train a cadre of PhD researchers who are prepared to conduct research at the interface between biomedical science and clinical medicine, where unparalleled opportunities exist to impact patient care. The purpose of this grant is to address this need and train the next generation of PhD scientists in interdisciplinary, translational research. We will employ a competency-based curriculum and provide clinical exposures to outstanding trainees in order to equip them to successfully translate basic science discoveries into clinical outcomes.

PI_NAMEs: LIEBERMAN, ANDREW P (contact);NIKOLOVSKA-COLESKA, ZANETA

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Training Program in Translational Research

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Pediatric endocrine diseases such as obesity, insulin resistance, and diabetes profoundly impact the future of both the affected individuals and society as a whole. There is an urgent public health need to educate physician scientists to tackle these critical problems through innovative scientific discovery and its translation into clinical practice. T32 funding since 2004 at the University of Minnesota has allowed a group of experienced mentors with extensive research experience to successfully train the next generation of academic pediatric endocrinologists.

PI_NAMEs: BELLIN, MELENA D. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Pre-faculty Research Training in Pediatric Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Drug addiction is a major public health concern, mainly characterized by high vulnerability to relapse despite sustained periods of recovery. The proposed experiments will characterize the mechanisms by which neuronal ensembles within the nucleus accumbens, a neural substrate for reward seeking and motivated behavior in the brain, encode cocaine seeking behavior and extinction training, in response to cocaine-associated context/cues. Knowledge gained from these studies will broaden our understanding on the circuitry coding drug-associated rewards, and therefore advance our fundamental understanding to the pathological neuroadaptations in the context of drug addiction.

PI_NAMEs: CHALHOUB, REDA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;addiction;Affect;Automobile Driving;awake;Behavior;Brain;career;cell type;Cells;Cessation of life;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine overdose;cocaine seeking;cocaine self-administration;Code;Computer Analysis;Computer software;Critical Thinking;Cues;Data;designer receptors exclusively activated by designer drugs;Disease;Doctor of Philosophy;Dopamine D1 Receptor;Dopamine D2 Receptor;Drug Addiction;drug seeking behavior;Drug usage;Ensure;Experimental Designs;experimental study;Extinction;Fellowship;Genetic;Glutamates;Goals;Head;Health;Image;Imaging technology;in vivo;Knowledge;Link;Measures;Mentors;Mentorship;Microscope;motivated behavior;mouse model;Mus;neural;neuroadaptation;Neurons;Neurosciences;Nucleus Accumbens;optogenetics;Pathologic;Pattern;Persons;Pharmaceutical Preparations;Physiology;Play;Protocols documentation;Public Health;public health relevance;Pythons;Recovery;Relapse;Research;Research Personnel;response;Rewards;Rodent Model;Role;Self Administration;skills;Statistical Models;Sucrose;Surveys;Synaptic plasticity;Techniques;Testing;Training;Transfection;Transgenic Mice;United States;Viral;Withdrawal;Writing

PROJECT_TITLE: Single Cell Encoding of Cocaine Seeking Behavior in the Nucleus Accumbens