NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative  The proposed research has important implications for diagnosis and management of ischemic heart disease and will impact health care by improving the reliability and accuracy of noninvasive imaging for evaluation of blood flow to the heart. This project will develop and validate novel deep learning-integrated techniques to significantly reduce variation in quantitative indices. It will yield a more accurate approach for detection of obstructive and non-obstructive coronary artery disease and patient risk stratification, and identification of irreversible scar in patients with heart disease referred for potential revascularization.

PI_NAMEs: SINUSAS, ALBERT J;TANG, JING  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Algorithms;Angiography;Animal Model;Animals;Blood flow;Cause of Death;Cicatrix;Clinical;Coronary;Coronary Arteriosclerosis;Coronary artery;Data;deep learning;denoising;Detection;Devices;Diagnosis;Diagnostic;diagnostic accuracy;digital;disease diagnosis;disease diagnostic;disorder risk;Evaluation;Face;Family suidae;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Four-dimensional;Health Care Costs;Healthcare;Heart;Heart Diseases;Heart failure;hemodynamics;Histologic;Human;Image;Image Analysis;image reconstruction;Imaging Techniques;improved;indexing;Individual;Infarction;Intervention;Ischemia;kinetic model;Kinetics;Learning;Measurement;Measures;men;Methodology;Methods;Microspheres;Microvascular Dysfunction;Modality;Modeling;Motion;Myocardial;myocardial infarct sizing;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Myocardial Reperfusion;Myocardium;Noise;non-invasive imaging;novel;Outcome;parametric imaging;Patient risk;patient stratification;Patients;Performance;perfusion imaging;Pilot Projects;Population;porcine model;Positron-Emission Tomography;pre-clinical;prognostic;prospective;Race;reconstruction;Research;Resistance;Resolution;respiratory;Rest;revascularization;Risk;risk stratification;Scanning;Severities;Signal Transduction;simulation;Stenosis;Stress;sudden cardiac death;Techniques;Testing;Time;tomography;Translating;Uncertainty;Validation;validation studies;Variant;Vision;Woman

PROJECT_TITLE: Novel methodologies to improve coronary artery disease diagnostics with dynamic PET

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE We discovered that loss-of-function mutations affecting the TRPC5 gene (encoding a calcium channel) can impair maternal behavior. Here we will further unravel the neurobiological mechanisms by which the Trpc5 channel maintains normal maternal behavior during the postpartum period, and will provide pre-clinical evidence to identify Trpc5 as a potential target to improve maternal behavior.

PI_NAMEs: XU, YONG  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Affect;Agonist;Amino Acids;Behavior;Brain;Calcium;Calcium Channel;Caring;CRISPR/Cas technology;Development;Discipline of Nursing;dopaminergic neuron;Electrophysiology (science);Exhibits;Experimental Genetics;Female;Fiber;Genes;Health;Human;Human Genetics;Hypothalamic structure;Impairment;improved;Infant;Ion Channel;Knock-in Mouse;loss of function;loss of function mutation;Mammals;Maternal Behavior;Modeling;Molecular;Mothers;mouse genetics;mouse model;Mus;Mutant Strains Mice;Mutation;neural circuit;neurobiological mechanism;Neurobiology;Neurons;novel;offspring;Oxytocin;paraventricular nucleus;Parents;pharmacologic;Photometry;polypeptide;Postpartum Period;pre-clinical;Prolactin;Proteins;Psychological Stress;psychological stressor;pup;rare variant;Regulation;restoration;Retrieval;Role;Stress;Substantia nigra structure;suckling;supraoptic nucleus;Testing;therapeutic target;TRP channel;Variant;Woman;Work

PROJECT_TITLE: Trpc5-activated neural circuits and maternal behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Genetics;Human Genome;Rheumatoid Arthritis

ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Rheumatoid Arthritis is ranked among the highest of all chronic diseases for its effect on health-related quality of life, directly affecting both the professional and personal lives of patients. Persistence of symptoms requires patients to remain on expensive biological disease-modifying drugs for a prolonged time. The goal of the research proposed in this application is to gain insights into the role of Set binding protein 1 (Setbp1) in the persistence of disease symptoms in rheumatoid arthritis patients.

PI_NAMEs: BHATTARAM, PALLAVI  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adolescent;Adult;Affect;aging process;Anti-Inflammatory Agents;Apoptosis;Arthritis;arthropathies;articular cartilage;Autoimmune;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Brain;cartilage degradation;Cell Line;Cells;ChIP-seq;Chronic;Chronic Childhood Arthritis;Chronic Disease;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;collagen antibody induced arthritis;Complex;Data;Defect;Development;Disease;Disease remission;DNA Binding;Down-Regulation;Doxycycline;Drug resistance;Embryonic Development;epigenetic memory;Epigenetic Process;epigenomics;Failure;Fibroblasts;Functional disorder;gain of function;gain of function mutation;Gene Activation;Gene Expression;gene repression;Genes;Genetic;Genetic study;genome editing;genome-wide analysis;genomic locus;Goals;health related quality of life;Hematopoietic;Heterozygote;Histone Deacetylase;histone modification;Histones;Homeostasis;Human;Hyperplasia;Impairment;Inflammation;Inflammatory;Inflammatory Arthritis;insight;joint destruction;Joints;Kidney;Knock-out;loss of function;loss of function mutation;Luciferases;Malignant Neoplasms;Methyltransferase;Molecular;Molecular Analysis;mouse model;Mus;Myeloproliferative disease;normal aging;Nucleic Acid Regulatory Sequences;Organ;Pathogenesis;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Play;prevent;Proliferating;promoter;Property;Proteins;Psoriatic Arthritis;recruit;Recurrence;Regulation;Reporter;Repression;Research;Rheumatoid Arthritis;Role;Schinzel-Giedion syndrome;Shapes;skeletal;Skeletal Development;skeletogenesis;SOX11 gene;SOX4 gene;Speech;subchondral bone;Symptoms;Synovial Membrane;Synovitis;Testing;therapeutic target;therapy resistant;Time;Tissues;TNF gene;transcription factor;Transcription Repressor;transcriptome sequencing;Up-Regulation;Writing

PROJECT_TITLE: Uncovering the role of Setbp1 in fibroblast-like synoviocytes during inflammatory arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Nearly half of all EGFR-mutant lung cancer patients develop brain metastasis, a severe complication that significantly shortens their survival. We identified S100A9 as a novel mediator of brain metastasis in EGFR- mutant lung cancer. This project proposes to identify potentially targetable up- and down-stream mechanisms of S100A9-mediated brain metastasis for the design of more effective treatments for lung cancer patients.

PI_NAMEs: ACHARYYA, SWARNALI  (contact);LU, CHAO

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Acceleration;Allografting;ATAC-seq;Binding;Biochemical;Biological Assay;Biology;Brain;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Carboxylesterase 1;Cell Fractionation;Cell Nucleus;Cells;Cellular Assay;Chromatin;Circulation;Clinical;Clone Cells;Complication;Cytoplasm;design;Development;Disseminated Malignant Neoplasm;effective therapy;Epidermal Growth Factor Receptor;Epigenetic Process;epigenetic regulation;epigenomic profiling;epigenomics;Exhibits;EZH2 gene;gain of function;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;histone methylation;histone methyltransferase;Histones;Immunocompetent;in vivo;inhibitor;Injections;interdisciplinary approach;lipid metabolism;lipidomics;Liver;loss of function;Lysine;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;MEIS1 gene;Metastatic malignant neoplasm to brain;Methylation;Methyltransferase;Modeling;Molecular Target;mortality;mouse model;Mus;mutant;Neoplasm Metastasis;novel;Nuclear;Nucleic Acid Regulatory Sequences;Pathway interactions;Patients;pharmacologic;prevent;Primary Neoplasm;Prognosis;Regulation;Resistance;S100A9 gene;Sampling;Slice;Technology;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Tissues;Transcription Coactivator;transcription factor;transcriptome sequencing;transcriptomics;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Mechanisms of S100A9-mediated brain metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project will provide whole genome sequencing (8,100), Alzheimer's disease (AD) plasma biomarkers (7,500), and cardiovascular disease (CVD) risk biomarker data (9,000) on African and African American individuals ascertained as part of the READD-ADSP U19. We will also collect longitudinal clinical and plasma biomarker data by recontacting and performing follow-up visits after ~4 years with cognitively intact and mild cognitively impaired individuals from this cohort. Analysis of this data will allow identification of rare genetic variants contributing to AD risk and protection and include biomarker and CVD markers in these models. This will add to this invaluable resource for the Alzheimer's disease (AD) research community to enhance efforts to discover targets for AD diagnosis, prevention, and treatment that apply to individuals of all ancestral backgrounds.

PI_NAMEs: BYRD, GOLDIE S.;GRISWOLD, ANTHONY JOHN (contact);HAINES, JONATHAN L;KUNKLE, BRIAN WILLIAM;PERICAK-VANCE, MARGARET A.;REITZ, CHRISTIANE ;VANCE, JEFFERY MARVIN

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;admixture mapping;African;African American;African American population;African ancestry;Aliquot;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Awareness;Biological Markers;Cardiovascular Diseases;cardiovascular disorder risk;Clinical;Clinical Data;clinical diagnosis;Cognitive;cohort;Collaborations;Communities;Data;Data Analyses;Data Set;Dementia;density;Diagnosis;Disease Marker;DNA;drug discovery;Elderly;ethnic diversity;Ethnic Population;European ancestry;follow-up;Follow-Up Studies;Funding;Generations;Genetic Predisposition to Disease;Genetic Recombination;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genotype;Glial Fibrillary Acidic Protein;Goals;health determinants;High Prevalence;Image;Individual;Light;Magnetic Resonance Imaging;mild cognitive impairment;Modeling;neurofilament;Nigeria;Nigerian;Not Hispanic or Latino;Participant;Pathway interactions;Pattern;Phenotype;Plasma;polygenic risk score;Population;Prevention;Quality Control;racial population;rare variant;Recontacts;recruit;Research;Resources;Risk;risk prediction model;Sample Size;Sampling;social;tau-1;Testing;Underserved Population;Visit;Whole Blood;whole genome

PROJECT_TITLE: Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M4)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Genetics;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PUBLIC HEALTH RELEVANCE Chronic Obstructive Pulmonary Disease (COPD) is among the most common and costly public health problems worldwide. While cigarette smoke is the predominant risk factor for the development of COPD, repeated infections contribute to persistent inflammation and progression of the disease. Our research proposal focuses on the role of lung macrophages in propagating chronic inflammation in patients with COPD exacerbations.

PI_NAMEs: GALLY, FABIENNE  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adopted;Agonist;Alveolar Macrophages;analog;Antigen Presentation;Binding;Cell Respiration;ChIP-seq;Chromatin;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoking;Clinical;clinically relevant;Complement 1q;cost;Data;Development;Disease;Disease Progression;Enhancers;Ensure;Epigenetic Process;Exposure to;fatty acid-binding proteins;Fatty Acids;FDA approved;Flare;Funding;Genetic Transcription;Genetic Variation;Human;human disease;Impairment;in vivo;Infection;Inflammation;Inflammatory;Isotopes;Link;Lung;Lung infections;Macrophage;Mediating;Metabolic;Metabolism;metabolomics;monocyte;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Receptors;Nucleic Acid Regulatory Sequences;Nutrient;oxidation;Pathogenesis;Pathway interactions;Patients;Phenotype;PPAR gamma;Public Health;public health relevance;pulmonary function;Pulmonary Inflammation;recruit;Regulation;repair function;repaired;Reporting;Research Proposals;Resolution;Respiratory Tract Infections;response;Risk Factors;risk variant;Role;Single Nucleotide Polymorphism;smoking exposure;targeted treatment;Therapeutic;Tissues;transcription factor;Work

PROJECT_TITLE: Role of FABP5 in COPD Exacerbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Rehabilitation;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative Autologous breast reconstruction is an important part of breast cancer rehabilitation for many patients. Our goal is to increase the efficiency of autologous breast reconstruction by helping the surgeon design patient-specific molds for shaping tissue into an acceptable breast form.

PI_NAMEs: FRANCIS, ASHLEIGH MICHELLE;MARKEY, MIA K;MERCHANT, FATIMA AZIZ (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;3D Print;Algorithm Design;Algorithms;Appearance;Autologous;Bilateral;biomedical informatics;Biometry;Body Image;Body part;Breast;Breast Cancer Rehabilitation;Caring;Child Care;clinical decision support;clinical practice;clinical translation;Complex;Contralateral Breast;design;Engineering;Esthetics;Evaluation;Exclusion;experience;Feminine;Financial Hardship;Goals;Healthcare;Image;image processing;improved;Individual;innovation;Machine Learning;Malignant Breast Neoplasm;Mammaplasty;Mandible;Mastectomy;Medical Care Costs;Modeling;Molds;multidisciplinary;Nipples;operation;Outcome Measure;Patients;Perception;Persons;Postoperative Period;primary outcome;Procedures;programs;psychosocial;Quality of life;Randomized Controlled Clinical Trials;randomized, clinical trials;reconstruction;Reconstructive Surgical Procedures;Recovery;Rehabilitation therapy;Research;Research Personnel;Resources;Risk Reduction;Services;Shapes;skills;Surgeon;System;Techniques;Technology;Tissue Donors;Tissues;Transportation;Work

PROJECT_TITLE: Clinical decision-support algorithms for interactive design of patient-specific breast molds

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Evidence is emerging that a process of cell competition helps eliminate abnormal cells with the potential to develop into cancers and cause aging. By identifying and characterizing the molecular processes involved, it will be possible to measure the extent of this process and develop approaches to reduce cancer incidence and promote healthy aging.

PI_NAMEs: BAKER, NICHOLAS E (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Abnormal Cell;Affect;Aging;Aneuploid Cells;Aneuploidy;AT-Hook Motifs;Biogenesis;Biological Assay;Biological Models;cancer cell;carcinogenesis;Cell Aging;Cell Communication;cell injury;Cell Nucleus;Cell Physiology;cell type;Cells;Chromosome abnormality;Chromosome Mapping;chromosome number abnormality;Chromosomes;Deterioration;Development;DNA Damage;DNA Transposable Elements;Drosophila genus;Excision;Frequencies;gain of function;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Models;Genome;genome integrity;Genomics;Genotype;hallmarks of aging;healthy aging;Heterozygote;Homeostasis;Human;Hyperplasia;in vivo;Incidence;insight;irradiation;knock-down;Label;Lead;loss of function;Malignant Neoplasms;Mammals;Measures;Molecular;Monosomy;mosaic;Mus;mutant;Mutation;Normal Cell;Normal tissue morphology;overexpression;Pathway interactions;Phenotype;prevent;pro-aging;Process;response;Ribosomal Proteins;Ribosomes;Role;Route;sensor;Signal Transduction;Time;Tissues;TP53 gene;transcription factor;transcriptomic profiling;tumor;Tumor Promotion;tumorigenesis;tumorigenic;Yeasts

PROJECT_TITLE: Cell Competition in Development and Homeostasis

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PHR: Project Narrative Prostate cancer is a commonly diagnosed cancer in American men that is largely treatable until it metastasizes and develops treatment resistance and neuroendocrine transdifferentiation (NET). We will use the unique models we have generated to understand the epigenetic mechanisms underlying PCa NET. Our results might identify potential therapeutic targets that control the tipping point of NET and also discover epigenetic biomarkers at the early phase of NET to predict disease progression.

PI_NAMEs: YU, JINDAN ;ZHAO, CHANGSHENG  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 3-Dimensional;Adenocarcinoma;Adenocarcinoma Cell;American;Architecture;Binding;Binding Sites;Biological Models;biomarker identification;cancer diagnosis;Cell Line;cell type;Cells;Cellular Morphology;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Clinical;Clonal Evolution;Collaborations;comparative;Data;demethylation;Development;Disease;Disease Progression;DNA;DNA Binding;DNA Methylation;Enhancers;Enzymes;epigenetic marker;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genomics;Growth;Hi-C;In Vitro;in vivo;Individual;Inherited;inhibitor;insight;Lead;LNCaP;Lung;Malignant neoplasm of prostate;Mediating;men;Methylation;Modeling;Modification;Molecular;multiple omics;mutant;Mutation;nanopore;Neoplasm Metastasis;neural;Neuroendocrine Cell;Neuroendocrine Prostate Cancer;Neurosecretory Systems;overexpression;Pancreas;Pathway interactions;Pattern;Phase;programs;promoter;Prostate;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer model;prostate cancer progression;Proteins;RB1 gene;recruit;Role;Sampling;Techniques;Testing;Therapeutic;therapeutic target;therapy resistant;Time;TP53 gene;transcription factor;transcriptional reprogramming;transcriptome;transcriptome sequencing;transcriptomics;transdifferentiation;Transitional Cell;Up-Regulation;whole genome

PROJECT_TITLE: Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE Our research has unveiled a novel class of tinyRNAs, shorter than 17 nucleotides, with unique functional characteristics distinct from traditional microRNAs. These tinyRNAs remain shrouded in mystery, as their intricate molecular mechanisms have yet to be fully unraveled. With our robust preliminary data as a foundation, our study promises to shed light on the roles of these tinyRNAs, holding immense potential for the advancement of RNAi therapeutics, while enhancing the comprehension of the molecular underpinnings in Argonaute mutation- associated neurodevelopmental disorders.

PI_NAMEs: NAKANISHI, KOTARO  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Binding;Binding Proteins;Binding Sites;Biogenesis;Biological Assay;Cells;Characteristics;Complex;Comprehension;Consensus;Cryoelectron Microscopy;Data;Exhibits;Exonuclease;expectation;Foundations;Gene Targeting;Genes;Goals;Guide RNA;HCT116 Cells;Human;Human Cell Line;in vivo;Incubated;infancy;insight;Interferons;Luciferases;Mass Spectrum Analysis;Messenger RNA;MicroRNAs;Microscope;Molecular;mutant;Mutation;Names;Neurodevelopmental Disorder;new technology;novel;novel therapeutics;nuclease;Nucleic Acid Binding;Nucleotides;Outcome;Paper;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phosphodiesterase I;Point Mutation;Production;Proteins;Randomized;Reporter;Reporting;repository;Research;RNA;RNA Interference Therapy;RNA-Induced Silencing Complex;Role;Side;Site;Small RNA;Solid;Stress;Structure;Sugar Phosphates;Testing;Therapeutic;transcriptome sequencing;Transfection;Vertebral column;Virus Diseases

PROJECT_TITLE: Structural and molecular basis for cityRNA (cleavage-inducing tiny RNA)-directed RNA cleavage by AGO3

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Given that distant metastases occur in 10%-50% of patients with surgically resected lung adenocarcinoma (LUAD), there remains an unmet need to understand the tumor genomics that drive the biology of metastases and to develop innovative adjuvant therapies that could decrease the risk of metastases and improve survival. SMARCA4 is one of the most frequently mutated genes in LUAD, and altered SMARCA4 promotes metastasis through ROR2/inactive GSK3β signaling pathway. The goals of this research project are to elucidate the mechanisms through which altered SMARCA4 regulates transcription and promotes metastasis of LUAD and to identify way(s) to specifically target this altered gene, decrease development of metastases, and, ultimately, save lives.

PI_NAMEs: JONES, DAVID R (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adenocarcinoma Cell;Adjuvant Therapy;Antibody-drug conjugates;ATAC-seq;ATP phosphohydrolase;biobank;Biological Assay;Biology;BRAF gene;Cell Lineage;Cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;clinical sequencing;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Dependence;Development;Disease;Distant Metastasis;driver mutation;Epidermal Growth Factor Receptor;factor C;Future;Gene Expression;Gene Mutation;Genes;Genetic Transcription;Genetically Engineered Mouse;Genomics;glycogen synthase kinase 3 beta;glycogen synthase kinase 3 beta inhibitor;Goals;Human;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Individual;innovation;Invaded;Investigation;knock-down;Knock-in;Knock-out;KRAS2 gene;loss of function mutation;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;member;Messenger RNA;Metastatic Neoplasm to the Lung;Modeling;Monitor;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;Nuclear;Oncogenic;Operative Surgical Procedures;Organoids;Orphan;Pathway interactions;Patients;Persons;pharmacologic;pre-clinical;Primary Neoplasm;Proteins;prototype;Publishing;Reaction;receptor;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;Research Project Grants;Resected;Risk;Role;ROS1 gene;Signal Pathway;SMARCA2 gene;SMARCA4 gene;Specimen;SWI/SNF Family Complex;System;Testing;Therapeutic;therapeutic target;Time;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Treatment Efficacy;tumor;Up-Regulation;Work

PROJECT_TITLE: Targeting the ROR2/p-GSK3bS9 pathway to suppress metastasis in SMARCA4-deficient lung adenocarcinoma


NIH_SPENDING_CATS: Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE Bone marrow transplantation (BMT) is the only curative treatment for many patients with blood diseases, but this potential cure is often limited by severe gastrointestinal symptoms that can prove fatal. To better understand these devastating complications, understand how they relate to other disease settings, and develop new treatments, we will lead a comprehensive interdisciplinary study of how the epidermal growth factor receptor and its activators impact the immune system and the stem cell compartment maintaining the intestines after BMT.

PI_NAMEs: HANASH, ALAN M (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Allogeneic Bone Marrow Transplantation;Allogenic;Amphiregulin;autocrine;Autocrine Communication;Autoimmunity;Biology;Bone Marrow Transplantation;CD4 Positive T Lymphocytes;Cell Compartmentation;cell killing;Cell Physiology;cell type;Clinical;clinical investigation;Collaborations;Complex;Conflict (Psychology);curative treatments;cytokine;Data;Disease;Environment;Epidermal Growth Factor;Epidermal Growth Factor Receptor;epithelial injury;Epithelium;epithelium regeneration;Equilibrium;Funding;gastrointestinal;gastrointestinal symptom;Goals;graft vs host disease;Hematological Disease;Human;Immune;Immune system;Immunobiology;Immunological Models;Immunologics;Immunology;improved;in vivo;Infiltration;Injury;Interdisciplinary Study;Interferon Type II;interleukin-22;intestinal epithelium;intestinal injury;Intestines;kinase inhibitor;Lead;LGR5 gene;Ligands;Lymphocyte;Mediating;Mediator;Memorial Sloan-Kettering Cancer Center;Microscopy;Modeling;Mucous Membrane;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;Organoids;Outcome;Paneth Cells;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Prevention;Production;Proliferating;Property;Publications;Publishing;rational design;receptor expression;receptor function;Receptor Signaling;Recovery;regenerative;Regenerative pathway;Regulation;Resources;response;Role;Signal Transduction;stem cell niche;stem cells;System;T cell infiltration;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Tissue Model;tissue regeneration;Tissues;Translating;translational approach;translational potential;tumor;Work

PROJECT_TITLE: Discriminating EGFR function in T cells and epithelium during immune-mediated tissue damage

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The focus of this research is to define the molecular determinants of memory of inflammation in the pancreas. Our proposal utilizes mouse models to establish that inflammatory memory in acinar cells features the AP-1 transcription factors and their binding partners; can be reversed through targeting of MAPK signaling upstream of AP-1 or AP-1 itself; and is driven by the effect of the cytokine IL-33 on acinar cells. These findings will drive our mechanistic understanding of inflammatory memory as a key target to ameliorate the sequelae of long-term consequences of inflammation in human disease.

PI_NAMEs: CHANDWANI, ROHIT  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Ablation;Acinar Cell;Acute;Address;Affect;airway epithelium;Amnesia;Articulation;Attenuated;Autoimmune Diseases;Automobile Driving;Binding;biological systems;Caerulein;cancer risk;Cell Compartmentation;cell type;Cells;Chromatin;Chronic;chronic inflammatory disease;Communicable Diseases;cytokine;Data;Deposition;Development;Duct (organ) structure;Enhancers;Environment;epigenetic memory;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;epithelial stem cell;experience;Fos-Related Antigens;Future;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;Histologic;Homeostasis;human disease;Immune;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injury;KRAS oncogenesis;long-term sequelae;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mediating;MEKs;Memory;Metaplasia;Molecular;mouse model;Mus;mutant;Mutation;Natural regeneration;Nuclear;Oncogenic;Organoids;Pancreas;pancreas development;Pancreatitis;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Phosphorylation;Protein Isoforms;Recombinants;Research;Resolution;response;response to injury;Risk Factors;Role;Secondary to;Shapes;Signal Transduction;Stimulus;Stress;synergism;Therapeutic;Time;Tissue Preservation;Tissues;tool;Transcription Alteration;transcription factor;Transcription Factor AP-1;tumor initiation;tumor microenvironment;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Defining the molecular determinants of inflammatory memory in the pancreas

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Crohn's Disease;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Pediatric

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Altered microbiota drive mucosal inflammation and clinical relapses in patients with Crohn’s Disease (CD). We will complete the first studies of the prebiotic human milk oligosaccharide, 2’-fucosyllactose (2’-FL), for enhancing beneficial microbiota and associated metabolites in CD patients. These studies will have a high impact in the field by providing critical phase I/IIa safety and efficacy data in support of a phase III randomized-controlled trial to test the efficacy of 2’-FL in directly modulating beneficial microbiota and thereby enhancing sustained clinical remission and mucosal healing.

PI_NAMEs: DENSON, LEE ARMISTEAD (contact);HYAMS, JEFFREY SAMUEL

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: adalimumab;Adult;Anti-Tumor Necrosis Factor Therapy;Antibodies;Award;beneficial microorganism;Bifidobacterium;Bile Acids;Biogenesis;Biological Assay;Butyrates;Child;Childhood;Chronic;Clinical;clinical practice;clinical remission;Clinical Research;Crohn's disease;cytokine;Data;Dietary Carbohydrates;Dietary Fiber;dietary supplements;Disease;Disease remission;Dose;dysbiosis;efficacy testing;Enrollment;Enzymes;Epithelial Cells;Epithelium;Excision;feeding;Fucosyltransferase;gastrointestinal symptom;Genes;Genetic Polymorphism;genetic signature;Glucose;Growth;gut inflammation;gut microbiota;healing;Health;Homeostasis;human milk oligosaccharides;improved outcome;Incidence;indexing;Individual;Infant;Inflammatory;Inflammatory Bowel Diseases;infliximab;innovation;Intake;intestinal epithelium;Intestines;Leukocyte L1 Antigen Complex;Life;Link;Lymphocyte Function;Metabolic;metagenomic sequencing;Metagenomics;microbial;microbiota;Mitochondria;mouse model;Mucositis;Mucous Membrane;novel;Outcome;Participant;Pathogenesis;Patients;Pediatric Crohn's disease;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;prebiotics;prevent;Production;Proteobacteria;Randomized;Randomized, Controlled Trials;Regulatory T-Lymphocyte;Relapse;response;Risk;Safety;Secretor blood group alpha-2-fucosyltransferase;Site;Supplementation;Testing;Therapeutic Intervention;TNF gene;United States National Institutes of Health;Volatile Fatty Acids;Withdrawal;young adult

PROJECT_TITLE: Dosing and Pilot Efficacy of 2'-Fucosyllactose in Inflammatory Bowel Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative In the previous funding period, we have successfully demonstrated the feasibility of high-density optical tomographic scanning of breast lesions using a fiber-less, portable, and translation-friendly instrument design. We have also developed a computational framework to efficiently analyze such high-density datasets that were previously challenging. By further enhancing optical spatial sampling density by measuring both amplitude and phase of modulated light at extended wavelengths, combined with innovations in reconstruction techniques, our next generation multi-modal breast imager is poised to further enhance breast cancer detection and clinical translation.

PI_NAMEs: FANG, QIANQIAN  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Acceleration;adaptive optics;Algorithms;angiogenesis;Architecture;Benign;Biophotonics;Biopsy;Breast;Breast Cancer Detection;breast cancer diagnosis;breast density;breast imaging;breast lesion;breast scan;Calibration;Cancer Detection;cancer diagnosis;Cessation of life;chromophore;Clinical;Clinical Data;clinical diagnosis;Clinical Research;clinical translation;Communities;computer framework;Computer software;cost;Data;data acquisition;Data Analyses;Data Set;density;design;Detection;Development;Diagnosis;Diagnostic;diffuse optical tomography;Digital Breast Tomosynthesis;Dimensions;experience;Foundations;Frequencies;Friends;Funding;Generations;Image;image guided;image reconstruction;image translation;imager;imaging approach;imaging modality;imaging system;Imaging Techniques;improved;In Situ;Individual;innovation;instrument;Lesion;Light;Lighting;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Measurement;Measures;Metabolism;Methods;Modeling;Morphologic artifacts;Multimodal Imaging;multimodality;next generation;non-invasive imaging;open source;open source tool;optical fiber;Optical Tomography;Optics;Patients;Pattern;Phase;Physiological;Play;Population;portability;prototype;reconstruction;Reporting;Research;Research Personnel;Resolution;Resources;Roentgen Rays;Role;Sampling;Scanning;Shapes;Solid;Speed;success;System;Techniques;Testing;Time;tomography;Translations;tumor;Woman

PROJECT_TITLE: Ultra-high-density, compressive and media- adaptive optical breast tomography platform


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Drugs of the mTOR inhibitor class hold great promise for healthy life extension. We will compare two mTOR inhibitors, rapamycin and everolimus, for safety, tolerability, and biological effects to determine the best drug, dose, and dosing regimen for use in healthy aging older persons. In addition, we will test various biomarkers that could be used in testing the effectiveness of mTOR inhibitors in future clinical applications.

PI_NAMEs: GINSBURG, BRETT C;KELLOGG, DEAN L;KRAIG, ELLEN  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: 70-kDa Ribosomal Protein S6 Kinases;Address;Adverse drug effect;Adverse effects;Adverse reactions;Aftercare;Age;age related;age related changes;Aging;appropriate dose;Biochemical;Biochemical Markers;Biological;Biological Assay;Biological Markers;Biopsy;Blood;Blood Cell Count;clinical application;Clinical assessments;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Data;Development;Disease;Dose;drug clearance;Drug Kinetics;drug metabolism;effectiveness testing;Elderly;Ensure;Exhibits;extend lifespan;Fasting;fasting glucose;Fatty acid glycerol esters;Female;follow-up;FRAP1 gene;Future;Glucose tolerance test;Goals;Half-Life;Health Surveys;healthspan;healthy aging;Hispanic;Human;human subject;hydrophilicity;improved;inflammatory marker;insight;Intercellular adhesion molecule 1;Life;Life Extension;Lipids;lipophilicity;Maintenance;male;Measurement;Measures;Metabolic;Monitor;mTOR inhibition;mTOR Inhibitor;Mus;Obesity;OGTT;old mice;older adult;Older Population;Oncology;open label;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phosphorylation;Placebo Control;placebo controlled trial;Placebos;Polypharmacy;Population;Predisposition;Protocols documentation;randomized placebo controlled trial;recruit;Regimen;Rejuvenation;repository;Research;Ribosomal Protein S6;Safety;safety assessment;Schedule;SDZ RAD;Serum;sex;Sirolimus;Skeletal Muscle;Specimen;Target Populations;Testing;Therapeutic;therapeutic development;Tissues;Toxic effect;Transplant Recipients;trial design;week trial

PROJECT_TITLE: RESTOR [Rapamycin and Everolimus Study Towards Older Rejuvenation]: An exploratory PK/PD study of mTOR inhibition in older human subjects

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M2)]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project will greatly expand the simulation capabilities of the FEBio software suite, which enables computer simulations in the fields of biomechanics and biophysics. This software already supports over 20,000 scientists in their research. The outcomes of the proposed research will expand scientific discovery and innovation by biomedical simulation scientists in the areas of biomechanics and biophysics.

PI_NAMEs: ATESHIAN, GERARD A.;WEISS, JEFFREY A. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Accounting;Address;Algorithms;Area;base;Biological;Biomechanics;Biomedical Research;Biophysics;body mechanics;chemical reaction;Chemicals;Code;Communities;Community Developments;Computational algorithm;computer framework;Computer Models;Computer Simulation;Computer software;Computing Methodologies;Coupling;Data;design;Development;Documentation;Elements;Environment;expectation;Failure;Fatigue;Feedback;Finite Element Analysis;fluid flow;Formulation;Funding;Future;Generations;graphical user interface;Image;innovation;Letters;Liquid substance;Mechanics;Methodology;Methods;Modeling;Modernization;National Institute of General Medical Sciences;Nature;novel;novel strategies;Outcome;Paper;parallelization;Phase;Physics;Plug-in;Positioning Attribute;Process;Progress Reports;Publications;Reaction;Research;Research Personnel;Science;Scientific Advances and Accomplishments;Scientist;Series;shear stress;simulation;software development;Software Engineering;Solid;solute;Structure;success;Surface;Techniques;Testing;theories;Thermodynamics;Time;Tissues;tool;Traction;United States National Institutes of Health;Validation;webinar

PROJECT_TITLE: Finite Elements For Biomechanics And Biophysics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Precision Medicine;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Abnormal tumor vascular networks in primary and metastatic liver cancers regulate treatment response; there are currently no tools to characterize their complex attributes longitudinally and non-invasively at bedside for diagnosis, treatment response prediction or continuous feedback to personalize treatment regimens. Here, we propose to introduce, evaluate and translate a 3D DCE-US analysis framework that utilizes the interconnected nature of voxels to capture complex vascular properties in cancer and beyond. Guided by a clinical roadmap to predict or guide patient-specific treatment responses in real-time, our approach will provide new decision support to indirectly reduce morbidities and costs in patients that don’t respond to treatment.

PI_NAMEs: EL KAFFAS, AHMED  (contact);HRISTOV, DIMITRE HRISTOV

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Adopted;algorithm development;Algorithms;Architecture;Biological Markers;Blood Vessels;cancer imaging;cancer therapy;Classification;Clinic;Clinical;Clinical Data;clinical decision support;clinically relevant;Communities;Complex;Computer software;contrast enhanced;Contrast Media;cost;Data;Data Set;design;Development;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic value;Evaluation;FDA approved;Feedback;Goals;Heterogeneity;Histology;Human;Image;imaging probe;improved;individualized medicine;interest;Liver;liver imaging;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Measurement;Measures;Metastatic Neoplasm to the Liver;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nature;novel;Outcome;Patient imaging;Patients;Performance;Perfusion;personalized medicine;physical model;Physiological;Physiology;Play;pre-clinical;Prediction of Response to Therapy;Property;Rapid diagnostics;Research;research clinical testing;response;Role;Sampling Errors;serial imaging;symposium;synthetic data;System;Testing;Three-dimensional analysis;Three-Dimensional Imaging;three-dimensional modeling;Time;Tissues;tool;Translating;treatment effect;treatment planning;Treatment Protocols;treatment response;tumor;tumor progression;Tumor Tissue;ultra high resolution;ultrasound;Validation;Variant;Vascular System;Venous

PROJECT_TITLE: A 3D DCE-US Interconnected Voxel Analysis Framework for Bedside Characterization of Tumor Vascular Properties in Liver Malignancies.


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE  In human and animal cells, DNA is condensed in a nucleoprotein complex termed chromatin that is essential for the maintenance of genome integrity and regulation of cellular functions. The goal of this project is to understand the chromatin structure in sperm cells and the function of protein factors that mediate its assembly and remodeling. Our work will help to design methods of diagnosis and treatment of human conditions that involve defects in sperm chromatin metabolism, such as infertility, as well as novel approaches to contraception.

PI_NAMEs: FYODOROV, DMITRY V (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Animals;Architecture;Back;Biochemical;Biochemical Reaction;Biological;Biological Models;Biophysics;cell growth regulation;cell motility;Cell Nucleus;Cell Physiology;Cells;Chaperone Gene;Charge;CHD1 gene;Chemicals;Chromatin;chromatin remodeling;Chromatin Structure;Chromosome Structures;Chromosomes;Complex;Contraceptive Agents;Contraceptive methods;coping;crosslink;Cysteine;cysteine rich protein;Defect;design;Development;Diagnosis;Disease;disulfide bond;Disulfides;DNA;Drosophila genus;Drosophila melanogaster;egg;Enzymes;Eukaryotic Cell;Evolution;Excision;Face;Family;female fertility;Fertility;Fertilization;fly;Genetic;Genetic Transcription;Genome;genome integrity;Germ Cells;Goals;Haploidy;Histones;Human;Importins;In Vitro;in vivo;Infertility;inhibitor;insight;Knowledge;Life Cycle Stages;Maintenance;male;Mediating;Meiosis;Metabolism;Methods;model organism;Molecular Chaperones;Molecular Structure;Mus;mutant;Needles;Normal Cell;novel;novel strategies;Nuclear;Nucleoproteins;Nucleosomes;Organism;Ovum;oxidation;Pharmaceutical Preparations;Physical condensation;Plant Leaves;Play;preservation;Process;Protamines;Protein Family;protein function;protein metabolism;Proteins;Recombinants;reconstitution;Regulation;Repression;Role;Sexual Reproduction;small molecule inhibitor;small molecule libraries;Somatic Cell;sperm cell;sperm function;Spermatids;Spermiogenesis;Structure;success;Surveys;System;thioredoxin reductase;tool;TXN gene;Work;zygote

PROJECT_TITLE: Sperm chromatin structure and remodeling during spermiogenesis and fertilization

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Child maltreatment, a significant public health problem that affects millions of youth each year, often evades successful intervention due to negative views of maltreated youths’ abilities to provide accurate and detailed reports about prior negative experiences. Evidence suggests that maltreated youth may actually remember stressful experiences quite well, better than non- maltreated youth do. Our proposed research will provide a rigorous test of this possibility, focusing on both how well maltreated youth remember stressful experiences and on mediators of their memory, and, in doing so, will offer crucial insight that can improve interventions aimed at reducing long-term harm caused by maltreatment.

PI_NAMEs: QUAS, JODI ANNE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 17 year old;Acute;acute stress;Address;Adolescence;Adolescent;Adverse effects;adverse outcome;Affect;Age;Child;Child Abuse and Neglect;child and adolescent victimization;child protective service;Childhood;Childhood Injury;Communities;cost;design;Diagnosis;diagnostic strategy;effective therapy;Emotional;Ethics;Event;Exhibits;experience;experimental study;Exposure to;Family;Family Violence;Goals;Image;improved;insight;Intervention;Investigation;Knowledge;Legal Intervention;life span;Link;maltreated children;maltreatment;Measures;Mediating;Mediator;member;Memory;Memory impairment;memory recognition;National Institute of Child Health and Human Development;Performance;Persons;Play;Prevention strategy;Public Health;Randomized;Reporting;Research;Research Support;Role;rumination;Shapes;Standardization;Stress;Stressful Event;successful intervention;Testing;Traumatic injury;treatment strategy;Trust;United States;Violence;virtual;Work;Youth

PROJECT_TITLE: STRESS, MEMORY, AND RUMINATION IN MALTREATED ADOLESCENTS

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative: Mitral valve prolapse is a common valvulopathy affecting 2-3%; while it is often benign, a subset of patients with MVP may develop arrhythmias, including sudden cardiac death. There are currently no good risk assessment tools for the infrequent but devasting consequence of sudden cardiac death. This project will utilize cardiac magnetic resonance to 1) study patients with mitral valve prolapse to characterize morphologic features associated with arrhythmic risk; 2) develop and validate a blood biomarker screening strategy to identify patients who may benefit from cardiac magnetic resonance imaging; 3) form a large multicenter observational registry to develop a risk prediction model for sudden cardiac death in patients with mitral valve prolapse.

PI_NAMEs: SHAH, DIPAN J. (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Arrhythmia;Assessment tool;Autopsy;Benign;Biological Markers;biomarker panel;biomarker validation;Blood;Blood specimen;Cardiac;cardiac magnetic resonance imaging;Cardiovascular system;Characteristics;Cicatrix;circulating biomarkers;cohort;contrast enhanced;Control Groups;coronary fibrosis;cost;cost effective;Darkness;design;Development;Diffuse;Echocardiography;Educational workshop;Enrollment;Event;extracellular;FDA approved;Female;Fibrosis;follow-up;Freezing;Future;Gadolinium;Goals;Heart Arrest;Heart Injuries;high risk;Implantable Defibrillators;improved;Incidence;Individual;Inferior;innovation;insight;interstitial;Intervention;Italy;Link;Magnetic Resonance;Maps;Methodist Church;Mission;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Monitor;Morphology;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Non-Invasive Detection;novel;Observational Study;Outcome;papillary muscle;Patient Selection;patient subsets;Patients;Phenotype;Plasma;Population;Primary Prevention;prospective;Prospective Studies;proteomic signature;Proteomics;Recommendation;Registries;repaired;Reporting;Research;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Sampling;screening;Series;Severities;sex;sudden cardiac death;Sudden Death;Techniques;Testing;Tissues;Traction;treatment trial;Troponin;United States National Institutes of Health;Ventricular Arrhythmia;Ventricular Premature Complexes;Ventricular Tachycardia;Woman

PROJECT_TITLE: Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic Biomarkers

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project aims to develop a new type of cancer vaccine that uses advanced genetic messages to target hard-to-treat malignancies like pancreatic cancer. Proposed studies will fine-tune the vaccine's composition, safety measures, and delivery in conventional and human immune system-engineered lab mice. By exploring how the new vaccines augment the efficacy of existent and emerging cell-based immunotherapies and tumor- targeted drugs, this work lays the foundation for future treatments that could be more effective and safer for pancreatic cancer patients.

PI_NAMEs: PARDI, NORBERT ;RADU, CAIUS GABRIEL (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Adjuvant;Adverse effects;Alleles;Animal Model;Antigens;Biological Models;cancer immunotherapy;cancer type;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cellular immunotherapy;Clinical;clinical investigation;clinical translation;clinically relevant;Combined Modality Therapy;comparative;Complex;COVID-19;Data;Dendritic Cells;Development;Dose;Dose Limiting;Drug Targeting;Effectiveness;efficacy evaluation;Elements;Engineering;Engraftment;Evaluation;Exhibits;Foundations;Future;gain of function;Genetic;Goals;Human;humanized mouse;immune activation;Immune system;Immunization;immunoengineering;immunogenicity;Immunotherapy;improved;Inflammatory;inhibitor;Innate Immune Response;innovation;KRAS2 gene;KRASG12D;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;mesothelin;Messenger RNA;mouse model;mRNA immunotherapy;Mus;mutant;Mutation;neoantigens;Nobel Prize;novel;novel strategies;novel vaccines;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Patients;Performance;pharmacologic;Play;prevent;Production;programs;Property;Reaction;Recurrence;Recurrent tumor;Research;RNA vaccine;Role;Safety;Series;side effect;Signal Transduction;small molecule inhibitor;Solid Neoplasm;synergism;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Uridine;Vaccine Design;vaccine efficacy;vaccine evaluation;vaccine immunotherapy;vaccine safety;Vaccines;Variant;Virus Diseases;Work

PROJECT_TITLE: Innovative mRNA vaccines to enhance the efficacy of T-cell transfer therapies against solid tumors

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Peripheral Neuropathy;Physical Activity;Prevention;Rehabilitation;Women's Health Research

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Narrative Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, we propose to study a noninvasive, social sensorimotor intervention – Adapted Argentine Tango – which targets motor control restoration, symptom alleviation, and treatment participation in concert.

PI_NAMEs: LUSTBERG, MARYAM B.;WORTHEN-CHAUDHARI, LISE C. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acoustic Stimulation;Address;Affect;Age;Aging;Argentine;Behavior;Biological Markers;biomechanical test;Biomechanics;Biophysics;Breast Cancer survivor;cancer diagnosis;Cancer Survivor;cardiovascular fitness;Cardiovascular system;Caregivers;Caring;chemotherapy;chemotherapy induced neuropathy;Chronic;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;cognitive load;cohort;Creativeness;cytokine;Dancing;Data;debilitating symptom;Disease;Dose;Electroencephalography;Emotional;Equilibrium;Equipment;Esthesia;evidence base;exercise intervention;experience;fall risk;falls;follow-up;Frequencies;functional improvement;functional restoration;Goals;Health;Home environment;Human;Impairment;improved;Incidence;Individual;Inflammation;Inflammatory;innovation;instrument;Intervention;intrinsic motivation;Investigation;Knowledge;Laboratories;Left;life span;Lower Extremity;Malignant Breast Neoplasm;Malignant Neoplasms;Measurable;Measures;Mediating;Mediator;Medical Oncology;Methods;Modality;Monitor;Motion;Motivation;Motor;motor control;Movement;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;Music;Neuropathy;neurophysiology;Neurosciences;neurotoxic;neurotoxicity;Nonpharmacologic Therapy;Oncology;Outcome;Pain;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;Performance;Periodicity;Persons;Phase;Physical activity;Physical Medicine;Physiological;Pilot Projects;point of care;Population;portability;Prevention;primary outcome;psychosocial;Quality of life;Randomized;randomized, clinical trials;randomized, controlled study;reduce symptoms;Reporting;Research;Research Personnel;response;restoration;satisfaction;Science;secondary outcome;Sensorimotor functions;Sensory;Signal Transduction;Skin Cancer;social;social engagement;standard of care;Survivors;survivorship;Symptom Burden;symptom management;symptomatic improvement;Symptoms;Task Performances;Testing;Training;Translating;Travel;treatment center;treatment effect;Underserved Population;Upper Extremity;Walking;wireless;Woman;Work

PROJECT_TITLE: Dance-based Avenues to Advance Nonpharmacologic treatment of Chemotherapy Effects (DAANCE): a multicenter trial

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project narrative Emotions are important for virtually every aspect of health and disease, but we do not yet have ways of measuring brain states related to specific emotions, and how these brain states are impacted by contextual factors. This project builds on recent breakthroughs in measuring human brain activity using pattern recognition, and uses these tools to define and validate emotional brain states in ways that can aid in the diagnosis, prevention and treatment of multiple brain disorders.

PI_NAMEs: CHANG, LUKE JOSEPH (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Accounting;Address;Affective;affective neuroscience;Anger;Autobiography;Behavior;Belief;Brain;Brain Diseases;Categories;Clinical Research;Collaborations;computational neuroscience;Computational Technique;Computer Vision Systems;contextual factors;Crying;Data;Decision Making;Depressed mood;Diagnosis;Dimensions;Disease;drug craving;emotion dysregulation;Emotional;emotional experience;Emotions;Event;experience;experimental study;Face;Facial Expression;Feeling;food craving;Foundations;Fright;Functional impairment;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Generations;Goals;Guilt;Health;Heart;Heart Rate;high dimensionality;Human;improved;Individual;Individual Differences;individual variation;innovation;insight;Intervention;Language;Lead;Life Experience;Link;Maps;Measurement;Measures;Memory;Mental Health;Modality;model generalizability;Modeling;Monitor;movie;multimodal data;multimodality;natural language;Natural Language Processing;negative affect;neural;Neurologic;Neurosciences;novel;Pain;Participant;Patient Self-Report;Pattern;Pattern Recognition;Periodicals;Personal Satisfaction;pharmacologic;Physiological;Play;Predictive Factor;Prefrontal Cortex;Prevention;Protocols documentation;psychologic;Psychopathology;Psychophysiology;reconstruction;Reporting;Research Personnel;resilience;Resolution;response;Rewards;Risk Factors;Role;Sampling;Semantics;Series;Signal Transduction;Smiling;statistics;Stimulus;System;Techniques;Television;Testing;Thinking;Time;tool;Training;Trust;Variant;verbal;virtual;visual tracking;Work

PROJECT_TITLE: Dynamic brain representations underlying emotional experience


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Precision Medicine;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Metastatic colorectal cancer harboring a BRAF mutation is associated with poor prognosis and limited treatment options, leading to approximately 75,000 deaths worldwide each year. Building upon our prior success profiling patient-derived tumor samples with an innovative kinase-activity mapping technology, now we seek to identify and target the key stress response programs that enable BRAF mutated colorectal cancer cells to adapt and survive under therapeutic pressure. Our long-term goal is to improve the survival of patients via tailored strategies to prevent drug resistance, restore therapeutic response, or trigger tumor cell elimination.

PI_NAMEs: ATREYA, CHLOE E.;COPPE, JEAN-PHILIPPE FRANCOIS MARIE (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Address;Antibodies;Apoptotic;autocrine;Award;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;biological adaptation to stress;Biological Assay;Biopsy;BRAF gene;cancer cell;Cancer Etiology;CDC2 gene;celecoxib;Cell Death;Cell Line;Cell Survival;Cells;Cessation of life;Chronic Disease;Clinical;Clinical Trials;cohort;Collaborations;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;combinatorial;Combined Modality Therapy;Computer Models;Computing Methodologies;Coxibs;Databases;Dependence;design;Detection;disorder control;Drug Combinations;Drug resistance;Drug Targeting;drug testing;Drug usage;EGFR inhibition;Enzyme-Linked Immunosorbent Assay;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Equilibrium;Feedback;Fluorescent Antibody Technique;gene therapy;Genetic;Genomic approach;Goals;IL8 gene;IL8RB gene;illness length;Immunofluorescence Immunologic;improved;in vitro Model;Individual;Induction of Apoptosis;Inflammatory;inhibitor;innovation;insight;Intervention;Libraries;Malignant Neoplasms;MAP Kinase Gene;Maps;Mass Spectrum Analysis;Measures;Mediating;MEKs;member;metastatic colorectal;mimetics;Modeling;Monitor;Mutate;Mutation;Nature;neoplastic cell;next generation;Oncogenes;panitumumab;Pathway interactions;patient derived xenograft model;Patient Representative;patient response;Patients;Peptide Library;Pharmaceutical Preparations;Pharmacotherapy;Phosphoproteins;Phosphotransferases;pressure;prevent;Prognosis;programs;Proteins;Proteomics;PTGS2 gene;Regimen;Research;Residual Neoplasm;Residual state;resilience;Resistance;Resistance development;Resources;response;Sampling;sensor;Signal Induction;Signal Pathway;Signal Transduction;standard of care;success;synergism;targeted therapy trials;targeted treatment;Technology;Testing;Therapeutic;therapy resistant;Time;tissue resource;tool;transcriptome sequencing;translational goal;treatment arm;treatment response;tumor;tumor growth;tumor progression;Tumor Suppression;Tumor Tissue;tumor xenograft;Up-Regulation;Update

PROJECT_TITLE: Kinome-guided Targeting of Cooperative Dependencies in BRAF Mutated Colorectal Cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Learning-induced myelin remodeling has emerged as a novel form of CNS plasticity with broad potential importance in learning, memory, and diseases like multiple sclerosis. The precise role of myelin remodeling in learning remains unclear, largely due to the absence of tools to experimentally perturb sheath dynamics. We propose an interdisciplinary, collaborative project to determine the role of oligodendrocyte calcium signaling in myelin remodeling, then to leverage this mechanistic insight to determine the roles of calcium-dependent myelin remodeling in learning.

PI_NAMEs: HUGHES, ETHAN GARRETT;ZUCHERO, JOHN B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;attenuation;Axon;Behavior;Behavioral;Biological;Brain;Ca(2+)-Transporting ATPase;Calcium;Calcium Signaling;Calpain;Cells;Cellular biology;Complex;Data;Development;disability;Disease;Gelsolin;Genetic;Goals;in vivo;in vivo imaging;Induced Neurons;innovation;insight;Knowledge;Learning;Length;Link;Memory;Metabolic;Methods;Modeling;Molecular;monocular deprivation;Motor;motor behavior;Motor Cortex;motor learning;multi-photon;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Natural regeneration;neural;Neuronal Plasticity;Neurons;neurotransmission;novel;Oligodendroglia;Pattern;Penetrance;Performance;Porifera;Positioning Attribute;post stroke;Proteins;Recovery of Function;Role;Specificity;Testing;Time;tool;Transgenic Mice;Translating;Visualization;Zebrafish

PROJECT_TITLE: Does Learning Require Calcium-Dependent Myelin Remodeling?

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: NARRATIVE Tissue-level processes of substantial medical relevance rely on proper regulation of gene expression patterns, established by signaling networks. However, the complexity of the dynamics, feedback regulation, and protein- protein interactions limit our understanding of these networks. In this proposal, our approach is to synergistically use quantitative experiments in live cells and predictive mechanistic modeling to overcome these roadblocks.

PI_NAMEs: REEVES, GREGORY T (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Apoptotic;Behavior;Binding;Biological;Biological Models;Biology;Blastoderm;Cactaceae;Cell Culture System;Cell Culture Techniques;Cell Nucleus;Cells;Chemical Engineering;Chemistry;Complement;Complex;Cytoplasm;Data;Decision Making;design;Development;Dorsal;Drosophila genus;Embryo;Enhancers;Ensure;Exhibits;experimental study;Feedback;Fluorescence;Fluorescence Recovery After Photobleaching;Formulation;Foundations;gastrulation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Goals;Human;imaging modality;in vivo;in vivo imaging;in vivo Model;Inflammation;inhibitor;Insecta;insight;intercellular communication;Label;live cell imaging;mathematical model;Measurement;Measures;Medical;Methods;Modeling;Natural Immunity;NF-kappa B;novel;Nuclear;Nuclear Import;Outcome;Pathway interactions;Pattern;Physics;predictive modeling;prevent;Process;protein complex;protein protein interaction;Proteins;quantitative imaging;Reaction Time;Regulation;response;Role;Scanning;Series;Signal Pathway;Signal Transduction;Signaling Protein;spatiotemporal;Specific qualifier value;Spectrum Analysis;synergism;System;Systems Biology;Techniques;Testing;Tissue-Specific Gene Expression;Tissues;training data;Work

PROJECT_TITLE: Systems-level Analysis of Dynamics and Regulation of the Drosophila NF-kappaB/Dorsal Signaling Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE We expect the results of this project will provide a new automated diagnostic tool based on novel magnetic resonance imaging techniques to identify prostate tumor. This will allow us to accurately identify target areas for radiation therapy in the prostate, and improve treatment outcome without increasing radiation toxicity.

PI_NAMEs: GUO, JIA ;JIANG, YUN ;QING, KUN  (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatomy;Area;arterial spin labeling;Benign;Biochemical;Biological;Biopsy;Blood;Blood flow;Brain;cancer radiation therapy;Clinical;clinically significant;Computer software;contrast enhanced;contrast imaging;Contrast Media;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease-Free Survival;Dose;Eligibility Determination;External Beam Radiation Therapy;Fingerprint;FOLH1 gene;Fractionation;Future;Gadolinium;Goals;high dimensionality;high risk;Hyperplasia;Image;Image Analysis;Image Guided Biopsy;Imaging Techniques;improved;Inflammation;Information Systems;Institution;intravenous administration;irradiation;Label;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurement;Measures;men;Methods;Motion;Nephrogenic Systemic Fibrosis;Noise;novel;novel strategies;Output;Pathology;Patient-Focused Outcomes;Patients;Performance;Perfusion;Physicians;Physiologic pulse;Physiology;Positron-Emission Tomography;Primary Neoplasm;Property;Prostate;prostate cancer risk;Prostate Cancer therapy;Prostatic Neoplasms;Prostatic Tissue;Protocols documentation;Protons;PSA screening;Quantitative Evaluations;Radiation therapy;Radiation Toxicity;recruit;Recurrence;Relaxation;Reporting;Reproducibility;Research;Resolution;Risk;Sampling;Sensitivity and Specificity;Signal Transduction;Site;standard of care;Statistical Models;System;Techniques;Technology;Testing;Tissues;tool;Tracer;Training;Treatment outcome;tumor;validation studies;Variant;Water

PROJECT_TITLE: Quantitative MRI to automatically delineate intraprostatic tumor for radiation therapy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Kidney Disease;Organ Transplantation;Prevention;Transplantation

PHR: NARRATIVE To address the unmet therapeutic need for antibody mediated rejection, we aim to develop and apply a drug repurposing pipeline to antibody mediated rejection (ABMR) expression profiles in kidney transplant recipients, to query publicly available drug-gene expression databases and to identify single and combination drug repurposing candidates for ABMR (Aim 1). We will further determine the mechanism of action of promising drugs or drug combinations in human cells and ABMR tissues, ex vivo (Aim 2). Further validation of efficacy for ABMR treatment will be tested in vivo, in a pre-clinical rodent model of ABMR (Aim 3).

PI_NAMEs: SARWAL, MINNIE M (contact);SIROTA, MARINA

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acceleration;Address;allograft rejection;Animal Model;Antibodies;Antibody Therapy;antibody-mediated rejection;Bar Codes;Biological Assay;Biological Process;Biopsy;Cell model;cell type;Cells;Chicago;Combined Modality Therapy;Complex;Consultations;cost;cytokine;Data;Data Analyses;data integration;Data Set;Databases;Disease;Drug Combinations;drug development;drug repurposing;efficacy evaluation;efficacy testing;efficacy validation;Endothelial Cells;Endothelium;experience;experimental analysis;experimental study;FDA approved;gene expression database;Gene Expression Profile;Genetic Transcription;Graft Rejection;Graft Survival;Histologic;Human;human tissue;Immune;Immunology;immunoregulation;Immunosuppressive Agents;improved;in silico;in vivo;in vivo evaluation;Inflammation;Inflammatory;Injury;interest;Kidney;kidney allograft;Kidney Transplantation;Kinetics;large scale data;Libraries;Maps;Mediating;Modeling;Molecular;Mus;Network-based;novel;novel strategies;novel therapeutics;organ transplant recipient;Organ Transplantation;Outcome;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;personalized approach;Pharmaceutical Preparations;pre-clinical;precision medicine;preclinical development;prevent;Prevention;Property;Publishing;Research Personnel;response;Rodent;Rodent Model;Safety;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;Therapeutic;Thinness;Time;Tissues;transcriptomics;Transplant Recipients;Treatment Efficacy;treatment response;Universities;Validation

PROJECT_TITLE: Computational Drug Repositioning for Antibody Mediated Renal Allograft Rejection

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Effective therapies for Alzheimer’s disease (AD) have remained elusive and new research avenues are needed. Candidate interventions with potential impact on AD are emerging from geroscience, including the use of compounds that increase healthspan and longevity. This project aims to understand the therapeutic potential of the protective mitochondrial-derived peptide MOTS-c against APOE genotype- and AD-related impairments, knowledge that could be rapidly translated into approaches to prevent and treat AD.

PI_NAMEs: LEE, CHANGHAN ;PIKE, CHRISTIAN J (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Affect;Age;age acceleration;age related;Age-associated memory impairment;Aging;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;analog;Apolipoprotein E;apolipoprotein E-3;Astrocytes;Automobile Driving;Categories;Cell Nucleus;Cells;Cellular Stress;Circulation;Clinical;clinical translation;combat;Data;design;Development;diet-induced obesity;effective therapy;Event;Exercise;Fatty Liver;Female;frailty;Gene Expression;Genetic Transcription;Genotype;geroprotector;Geroscience;Goals;healthspan;Hepatocyte;Homeostasis;Human;Immune;Impaired cognition;Impairment;improved;Inflammatory;Insulin Resistance;Intervention;Knock-in;Knowledge;late life;life span;Link;lipid metabolism;Lipids;Longevity;Macrophage;male;Measures;Mediating;Metabolic;Metabolism;Microglia;Mitochondria;mitochondrial genome;mitochondrial therapeutics;Modeling;monocyte;mortality;mouse model;Mus;Names;neural;Neurons;novel;Nuclear;Obesity;Open Reading Frames;Outcome;Outcome Measure;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peptides;Peripheral;Phagocytes;Phase Ib Clinical Trial;Phenotype;Physical Capacity;Pike fish;pre-clinical;prevent;Prevention;programs;Proteins;Regulation;Research;response;Ribosomal RNA;Risk;Role;sex;Sex Differences;Signal Pathway;Stress;stressor;System;tau Proteins;Testing;Therapeutic;Transgenes;Translating

PROJECT_TITLE: MOTS-C, APOE, and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Public Health Relevance Section Aging is associated with a striking increase in the incidence of stroke, which is a major cause of disability among those aged 65 years and older. Studies described in this proposal are significant because they will provide a new therapeutic strategy for treating stroke in the elderly.

PI_NAMEs: REN, XUEFANG SOPHIE  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Active Sites;Acute;aged;Aging;aging brain;American;Animals;aptamer;attenuation;Binding;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood donor;Blood Substitutes;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Infarction;Brain Injuries;Cells;cerebral artery;Cerebral Infarction;Cerebral Ischemia;cerebrovascular;Clinical;clinical translation;cognitive function;Competitive Binding;Data;design;disability;Distal;Dysplasia;EF Hand Motifs;effective therapy;Effectiveness;Elderly;Endothelial Cells;Evolution;Extracellular Matrix Degradation;Extravasation;Female;Filament;Flow Cytometry;Fluorescence;functional disability;Future;Gelatinase B;Goals;Histologic;Hour;Human;human old age (65+);improved;improved outcome;In Vitro;in vivo;Inbred BALB C Mice;Infarction;Integral Membrane Protein;Interruption;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Label;Leucine Zippers;Leucocytic infiltrate;Long term disability;Magnetic Resonance Imaging;Maintenance;male;Matrix Metalloproteinases;Membrane Potentials;Methods;middle cerebral artery;Middle Cerebral Artery Occlusion;Mitochondria;mitochondrial membrane;Mitochondrial Membrane Protein;Modeling;mortality;Motor;Mus;Neurologic Deficit;Neurological outcome;neuron loss;neutrophil;novel;novel therapeutic intervention;novel therapeutics;old mice;older patient;Outcome;Oxidative Phosphorylation;Patients;Peptide Hydrolases;Peptides;Phase;Play;Positioning Attribute;post stroke;preservation;protective effect;protein degradation;protein structure;Proteins;public health relevance;Reaction;Recovery of Function;Reporting;Research;Role;Severities;Signal Transduction;Site;Source;Specificity;Stroke;stroke incidence;stroke model;stroke outcome;stroke patient;stroke therapy;Structure;success;Testing;therapeutically effective;three dimensional structure;Whole Blood;Withdrawal

PROJECT_TITLE: A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged Brain

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed research holds significant public health relevance due to the pervasive and concerning environmental exposure to microplastics. Colorectal cancer is a disease associated with substantial morbidity and mortality, and effective treatments are currently lacking. The outcomes of this research will provide a fundamental understanding of the molecular mechanisms underlying colon tumor development following exposure to microplastics. This, in turn, will pave the way for the development of innovative strategies for preventing and treating the harmful effects of microplastics. Therefore, this proposal aligns with the NIH's objective to establish research strategies for disease prevention and treatment.

PI_NAMEs: XUE, XIANG  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;American Indians;Archives;Automobile Driving;Calcium Signaling;cancer cell;Cell Physiology;Cellular Structures;Chronic;Clinical;Colon;colon growth;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;Colorectal Neoplasms;Communities;Comprehension;Consumption;Data;Development;Disease;disorder prevention;dysbiosis;Ecosystem;effective therapy;Elements;Environment;Environmental Exposure;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;experimental study;exposed human population;Exposure to;Face;Food;Food Contamination;Functional disorder;Genetic;Goals;Growth;gut inflammation;Health;high risk;Hispanic;Human;human tissue;Hypoxia;Hypoxia Inducible Factor;improved;In Vitro;in vivo;Inflammation;Ingestion;Inhalation;innovation;insight;interest;intestinal epithelium;Intestines;Investigation;Ion Channel;Link;Liver;mechanotransduction;Mesenchymal;Metastatic Neoplasm to the Liver;migration;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;New Mexico;Oncogenic;Organ;Outcome;Outcomes Research;Oxidative Stress;particle;Patients;Persons;Piezo 1 ion channel;Plastics;pollutant;Pollution;Population;Pre-Clinical Model;prevent;Preventive;Production;public health relevance;Quality of life;Reactive Oxygen Species;Reporting;Research;response;Risk;Role;Signal Pathway;Signal Transduction;Skin;STEM research;Survival Rate;Therapeutic;three dimensional cell culture;tissue culture;Tissues;Toxic effect;Toxicant exposure;tumor;tumor growth;tumor progression;United States National Institutes of Health;Validation;Water;Weight

PROJECT_TITLE: Mechanisms for environmental microplastics-enhanced colorectal tumor progression

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This project focuses on continued expansion of the Neurosynth framework for large-scale synthesis of functional MRI data. Neurosynth is a web-based platform that enables users to use artificial intelligence to summarize and synthesize the results of thousands of individual neuroimaging studies, making it easier for basic and clinical researchers to generate and test hypotheses about brain function.

PI_NAMEs: DE LA VEGA, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Age;Artificial Intelligence;Atlases;automated analysis;Basic Science;Benchmarking;Brain;Clinical;Clinical Research;cloud based;Cognitive;cognitive task;Collection;Communities;Comprehension;concept mapping;Consumption;Custom;Data;data curation;Data Set;Databases;demographics;Development;Disease;Ecosystem;Ensure;experience;Experimental Designs;flexibility;Frequencies;Functional Magnetic Resonance Imaging;Glean;Goals;Grain;Growth;Hour;Human;Image;Individual;information framework;Information Retrieval;Infrastructure;insight;Internet;Journals;knowledge base;Label;Language;large language model;Libraries;Literature;Manuals;Maps;Meta-Analysis;Metadata;Methodology;Methods;Modeling;Natural Language Processing;neuroimaging;Online Systems;Ontology;open source library;open source tool;Participant;Phenotype;Process;Publishing;Reproducibility;Research;Research Personnel;Resources;Retrieval;Sample Size;Science;Semantics;Services;shot learning;software development;Specific qualifier value;Standardization;Statistical Methods;Techniques;Testing;text searching;Time;tool;Update;Validation;web app;web platform

PROJECT_TITLE: Large-scale meta-analysis of functional MRI data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative We have identified a highly specific tumor cell surface antigen that is not expressed by any other normal tissue except for the placenta. We have also identified a human monoclonal antibody that binds to this tumor-specific antigen with high affinity and specificity. We propose to leverage this exquisite target specificity to develop a bispecific antibody with one arm targeting tumor and the other engaging the T cell with an optimized affinity to achieve highly potent and specific tumor cell killing without causing excessive cytokine release, and translate this novel immunotherapeutic to clinical trials in the near future.

PI_NAMEs: LIU, BIN  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;Antibodies;Antibody Binding Sites;antibody engineering;antigen binding;Antigens;Architecture;arm;Bacteriophages;bi-specific T cell engager;Binding;biophysical properties;Bispecific Antibodies;cancer therapy;cancer type;CD19 gene;CD22 gene;CD3 Antigens;cell killing;Cell surface;Cells;Clinic;Clinical;clinical translation;Clinical Trials;Combined Modality Therapy;crosslink;cytokine;cytokine release syndrome;cytotoxicity;design;Development;Dose Limiting;efficacy evaluation;Endometriomas;Engineering;FOLH1 gene;Future;Generations;Half-Life;Hematologic Neoplasms;Hematology;human monoclonal antibodies;Immunotherapeutic agent;improved;in vivo;Lead;Libraries;Liquid substance;Lung;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of testis;Malignant Neoplasms;malignant stomach neoplasm;Masks;Mass Spectrum Analysis;Mediating;member;mesothelin;Mesothelioma;Molecular;Monoclonal Antibody HuM291;MS4A1 gene;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Ovarian;Pancreas;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Placenta;research clinical testing;Risk;side effect;Solid Neoplasm;Specificity;Specimen;Stomach;success;Surface Antigens;System;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;therapy development;Tissues;Toxic effect;Translating;Translations;trend;tumor;Tumor Antigens;tumor microenvironment;United States;Variant;Xenograft procedure

PROJECT_TITLE: Bispecific T cell engager targeting a highly specific tumor cell surface antigen

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE  Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with human traits but have largely ignored the contribution of complex genetic variants such as repeats. This project leverages our frameworks for incorporating analysis of repetitive regions of the genome into GWAS and high- throughput experimental techniques to characterize the role of repeats in a wide range of human phenotypes.

PI_NAMEs: GOREN, ALON ;GYMREK, MELISSA  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: 3' Untranslated Regions;Affect;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Blood;candidate identification;case control;Catalogs;causal variant;Cell Differentiation process;Cell Line;cell type;Complex;computational suite;computerized tools;Data;Data Set;design;DNA Methylation;Enhancers;Environment;Exhibits;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic Polymorphism;genetic variant;Genetic Variation;Genome;genome editing;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;Human;Human Genetics;Individual;induced pluripotent stem cell;LDL Cholesterol Lipoproteins;Length;Link;Maps;Medical;Methods;Minisatellite Repeats;model generalizability;Modeling;molecular array;Molecular Biology;molecular phenotype;Mutation;next generation sequencing;novel;Phenotype;Platelet Count measurement;Play;Polygenic Traits;Population;promoter;Publishing;Quantitative Trait Loci;Repetitive Sequence;Reporter;Resources;RNA Splicing;Role;Sampling;Serum;Sex Chromosomes;Short Tandem Repeat;Signal Transduction;Single Nucleotide Polymorphism;Source;statistics;Tandem Repeat Sequences;Techniques;technology development;Testing;tool;trait;transcriptome sequencing;Variant;whole genome;Work

PROJECT_TITLE: Systematic characterization of tandem repeat variants contributing to complex traits

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  The mission of the University of Washington (UW) Research and Engagement on Adaptation for Climate and Health (REACH) Center is to leverage implementation science in support of implementing evidence-based health adaptation at scale. The REACH Center will also advance several other innovations, including a novel climate and health decision support tool (the Climate and Health Risk Tool, or CHaRT), a new climate and health implementation science curriculum, a new interdisciplinary planetary health curriculum at the UW School of Medicine, a suite of pilot climate and health intervention activities in communities in the Pacific Northwest, and community engagement activities in support of the research project and the climate and health interventions.

PI_NAMEs: HESS, JEREMY JOHNSON (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Affect;climate adaptation;climate change;climate-related health;Communities;community engaged research;community engagement;Community of Practice;community setting;Development;Discipline;Distant;Educational Curriculum;Effectiveness;effectiveness evaluation;Evaluation;evidence base;Evidence based intervention;Fellowship Program;Health;Health Resources;Health Sciences;Healthcare;Human;implementation science;innovation;Institution;Intervention;medical schools;meetings;member;Mission;National Institute of Environmental Health Sciences;novel;Output;Pacific Northwest;Peer Review;Personal Satisfaction;Pilot Projects;Policies;programs;Public Health;Publications;Randomized, Controlled Trials;Readiness;recruit;repository;Research;Research Project Grants;Research Support;Resources;Risk;Risk Reduction;support tools;tool;Training;Training Programs;Translations;Universities;uptake;Washington;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

PROJECT_TERMS: Achievement;Administrator;Affect;authority;Budgets;career;career development;climate adaptation;climate change;climate-related health;cohesion;Collaborations;Communication;community engagement;Community of Practice;cost;Creativeness;data infrastructure;data management;data sharing;Decision Making;Disputes;Documentation;Elements;Ensure;equity, diversity, and inclusion;Evaluation;Evaluation Research;Faculty;Grant;Guidelines;Health;implementation research;Infrastructure;Institution;Institutional Review Boards;Intervention;meetings;member;Mentorship;Mission;Phase;Progress Reports;Reporting;Research;Research Activity;Research Personnel;Resolution;Resource Allocation;Resources;success;Training;Translational Research;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PROJECT_TERMS: Address;Adoption;Automobile Driving;Censuses;Cities;Climate;climate adaptation;climate change;climate-related health;Communities;Community of Practice;Consolidated Framework for Implementation Research;Control Groups;cost;County;Data;Decision Making;demographics;Development;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Evaluation;evidence base;Evidence based intervention;experience;extreme heat;Foundations;Future;Goals;group intervention;hazard;Health;Health protection;Health Resources;implementation intervention;implementation science;implementation tool;Inequity;informant;innovation;insight;Intervention;intervention delivery;Intervention Studies;Interview;Link;Location;Maps;Measures;meetings;member;Methods;National Institute of Environmental Health Sciences;novel;Output;Participant;Peer Review;Policy Maker;Population;population health;Positioning Attribute;Process;Program Evaluation;protective effect;Public Health;Publications;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;repository;Research;Research Project Grants;Resources;Risk;Risk Assessment;Risk Reduction;Series;support tools;Time;timeline;tool;Translating;trial comparing;United States;Washington;web site;Work

PROJECT_TITLE: CHaRT Implementation Research Project


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BUSCH ISAKSEN, TANIA  (contact)

PROJECT_TERMS: Address;Alaska;Area;climate adaptation;climate change;climate-related health;Collaborations;Communication;Communities;community advisory board;community building;community engagement;Community Physician;community science;Complex;Development;empowerment;Evaluation;Event;extreme heat;Financial Support;Fostering;Future;global environment;graduate student;hazard;Health;health literacy;Health protection;Idaho;improved;Institution;interdisciplinary collaboration;Knowledge;Leadership;literacy;Measures;Medical;Medical Education;medical schools;member;Methodology;Montana;Needs Assessment;Outcomes Research;Output;Pacific Northwest;Patient Care;Patients;Physicians;Pilot Projects;Research;Research Personnel;Research Project Grants;Research Support;resilience;Resources;response;Risk;Rural;symposium;tool;Training;Training Programs;Training Support;Translational Research;underserved urban area;Universities;Washington;Work;Wyoming

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Dissemination and Implementation Research

PI_NAMEs: ERRETT, NICOLE ANN (contact)

PROJECT_TERMS: Awareness;Climate;climate adaptation;climate change;climate zone;climate-related health;cohort;Collaborations;Communities;community engagement;Community of Practice;community organizations;community setting;Consultations;design;Development;Educational Curriculum;empowerment;Evaluation;Faculty;Fellowship;Fellowship Program;Funding;Generations;Goals;Government;Health;health care service organization;health care settings;Health Resources;Healthcare;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;innovation;Intervention;Investigation;Knowledge;Lead;Link;Methods;multidisciplinary;National Institute of Environmental Health Sciences;novel;Output;peer;peer learning;Persons;Pilot Projects;Production;programs;prospective;Public Health;Public Health Practice;recruit;repository;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;scale up;Series;Services;Speed;summer institute;tool;Training;Translating;Universities;uptake;Washington;web site;webinar;Work

PROJECT_TITLE: Implementation and Evaluation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative This project will examine how educational experiences affect long-term cognitive health leveraging quasi- experimental variation in the content or quality of education in the 1950s-60s due to the National Defense Education Act's provision of K-12 and college resources to improve education in science, technology, engineering, mathematics, and foreign language. It will also examine heterogeneity in impacts by sex, race, geography, childhood socioeconomic status and genetic predisposition for cognitive decline, which is important given large variability in cognitive impairment as well as in the content and quality of education across place, race, or socio- economic status. This study will have a high impact because it will create new data on educational experiences linkable to existing, but rarely combined, surveys to address one of today's costliest health concerns – Alzheimer's disease and related dementia, and because it will provide the first causal evidence of how educational experiences impact cognitive function, with a particular focus on quantitative coursework - where racial and SES gaps mirror those for dementia.

PI_NAMEs: GRACNER, TADEJA  (contact);MULHERN, CHRISTINE

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Affect;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Birth;brain health;Characteristics;Childhood;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;college;Community Surveys;Data;Data Set;Dementia;dementia risk;demographics;Diabetes Mellitus;Diet;disability;drinking;Early identification;economic outcome;Economics;Education;Educational Assessment;Engineering;Ethnic Origin;executive function;Exercise;Exhibits;experience;Exposure to;foreign language;Funding;Genetic Predisposition to Disease;Geography;Health;Health behavior;Health behavior and outcomes;Heart Diseases;Heterogeneity;high school;Hour;Hypertension;Impaired cognition;improved;Individual;innovation;Investments;late life;Life;Link;Literature;Long-Term Effects;Longitudinal Surveys;Low income;Malignant Neoplasms;mathematical ability;Mathematics;Measures;Mediating;Mediation;Memory;Methods;modifiable risk;multiple datasets;National Health and Nutrition Examination Survey;Natural experiment;Neurobehavioral Manifestations;Occupations;older adult;Outcome Assessment;Pathway interactions;Persons;Population Sizes;Poverty;processing speed;programs;Pupil;Quasi-experiment;Race;Randomized;Reading;Research;Resource Allocation;Resources;Respondent;Retirement;Risk Factors;Schools;Science;Science, Technology, Engineering and Mathematics;sex;sex variable;skills;Smoking;Socioeconomic Status;spatiotemporal;Stroke;Students;Subgroup;Surveys;teacher;Technology;Time;time use;Training;United States;Variant;verbal;Writing

PROJECT_TITLE: Long-term Effects of Educational Investments on Cognitive Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]