NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Millions of people are exposed to repetitive head impacts (RHI) from American football and other contact sports and may be at increased risk for dementia including due to the neurodegenerative disease, chronic traumatic encephalopathy (CTE). Research diagnostic criteria for the clinical manifestation of CTE pathology were developed, known as traumatic encephalopathy syndrome (TES); however, making a CTE diagnosis during life is limited because there are currently no validated biomarkers for underlying CTE pathology, longitudinal studies are lacking, distinctions of the clinical features and biomarkers of CTE from those of Alzheimer’s disease and related dementias are unknown, and risk and resilience factors of TES are unclear. This R01 will retain and grow a unique, well-characterized, longitudinal established cohort of people at high risk for CTE and test aims focused on advancing our ability to diagnose CTE in life in order to pave the way for identification of treatment and prevention targets.

PI_NAMEs: ALOSCO, MICHAEL  (contact);RABINOVICI, GIL DAN;REIMAN, ERIC MICHAEL;STERN, ROBERT A

PROJECT_TERMS: Acceleration;African American;Age;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Amyloid beta-Protein;Anxiety;Arizona;Atrophic;Autopsy;Award;Biological Markers;biomarker validation;Black race;Blood;Blood Vessels;Brain;chronic traumatic encephalopathy;cingulate cortex;Clinical;clinical examination;Cognitive;cognitive control;cohort;college;Communities;Consensus;contact sports;Cross-Sectional Studies;daily functioning;Data;Data Set;Dementia;dementia risk;design;Detection;Development;Diagnosis;diagnostic criteria;Diagnostics Research;Disease;disease diagnosis;Enrollment;Epitopes;Evaluation;Examinations and Diagnoses;executive function;Exposure to;formycin triphosphate;Frequencies;Functional Magnetic Resonance Imaging;Funding;Glial Fibrillary Acidic Protein;Goals;Growth;Head;head impact;high risk;Home;hypoperfusion;Impaired cognition;insight;Interleukin-6;Knowledge;Length;Life;life span;Liquid substance;Longitudinal cohort;Longitudinal Studies;Magnetic Resonance Imaging;male;Manufactured football;Measures;medial temporal lobe;Memory;Mental Depression;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neurobehavioral;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;neuropsychiatry;Newly Diagnosed;Outcome;Participant;Pathologic;Pathology;Patients;Pattern;Persons;Phenotype;Plasma;Play;Populations at Risk;Positron-Emission Tomography;Prevention;Probability;Prognosis;Publishing;Race;recruit;Research;Research Project Grants;resilience;resilience factor;Resources;retention rate;Risk;Risk Factors;Septum Pellucidum;Severities;sex;social health determinants;South Texas;Specificity;Symptoms;Syndrome;tau Proteins;tau-1;Testing;Tracer;treatment trial;uptake;validation studies;vascular injury;Visit;white matter;white matter injury

PROJECT_TITLE: Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Immunotherapy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Although the last five years have seen tremendous advancements in the use of tau biomarkers in blood, there remains a need to discover new and improved markers that will better inform on risk of cognitive decline in Alzheimer’s disease (AD) or aid in an earlier diagnosis of progressive supranuclear palsy (PSP) or other non- AD tauopathies. Results from our innovative studies will provide additional evidence of tau proteoform differences in the human brain between AD and PSP and explore how tau immunotherapy treatment influences what forms are identified in blood. These studies will identify biomarker candidates for exploration of clinical utility across primary tauopathies, and will have potential to inform on progression, enable earlier diagnosis, and enable clinical trials at earlier stages.

PI_NAMEs: DAGE, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;assay development;Autopsy;Binding;biobank;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Blood;Blood specimen;blood-based biomarker;Brain;brain tissue;candidate marker;Cerebrospinal Fluid;Characteristics;Clinical;Clinical Trials;Development;Diagnosis;Disease Progression;disorder control;Dose;Early Diagnosis;Early Intervention;Epitopes;Etiology;Evaluation;Fostering;Future;genetic association;Goals;Haplotypes;healthy volunteer;Heart;Human;Hydrolysis;Immunoprecipitation;Immunotherapy;immunotherapy trials;Impaired cognition;improved;innovation;Mass Spectrum Analysis;Measures;Metabolic Clearance Rate;Methods;Neurodegenerative Disorders;nonalzheimer dementia;novel;novel marker;Pathologic;Pathology;Patients;Performance;Phase;Phosphorylation;Plasma;pre-clinical;Progressive Supranuclear Palsy;public health relevance;Publishing;Recommendation;Research;Resources;Risk;Sampling;screening;specific biomarkers;success;Surveys;tau Proteins;tau-1;Tauopathies;Testing;Time;Tissues

PROJECT_TITLE: Discovery of novel tau proteoforms as biomarker candidates for AD and PSP

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Community health centers (CHCs) serve a large share of racial and ethnic minority patients and have disproportionately low colorectal cancer (CRC) screening rates compared to the general population. Even a delay of a few years for screening initiation can lead to increased CRC incidence and mortality. Using a rigorous mixed methods approach, the proposed research will identify equity-driven implementation strategies to initiate CRC screening in previously unscreened individuals 45 to 54 at a CHC with a predominantly Black patient population, and advance our understanding of strategies to increase CRC screening in the newly eligible population aged 45 to 49 at CHCs.

PI_NAMEs: ANYANE-YEBOA, ADJOA  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;aged;Attention;Award;black men;black patient;Black Populations;Black race;black women;Boston;Cancer Etiology;career;career development;Cessation of life;Cities;Clinical Investigator;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;community engaged research;community partners;Consolidated Framework for Implementation Research;Data;Death Rate;Dedications;design;Development;Development Plans;Disparity;Electronic Health Record;Eligibility Determination;Ensure;Equity;ethnic minority;Evidence based intervention;experience;Foundations;Funding;General Population;Goals;Guidelines;Health;health equity;implementation science;implementation strategy;improved;Incidence;Income;Individual;Inequity;inner city;innovation;International;Interview;K-Series Research Career Programs;Knowledge;Learning;lens;Maps;marginalization;marginalized population;Massachusetts;men;Mentors;Mentorship;Methodology;Methods;minority patient;Modeling;mortality;Neighborhood Health Center;Neighborhoods;Outcome;outreach;patient population;patient registry;Patients;Persons;pilot trial;Population;Positioning Attribute;Poverty;primary outcome;Qualitative Research;racial disparity;racial minority;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Methodology;Research Personnel;Research Project Grants;screening;skills;Surveys;System;Target Populations;Testing;Time;tool;Training;United States Preventative Services Task Force;uptake;urban area;Woman;Work

PROJECT_TITLE: Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE Coronary artery disease is the leading cause of death in the United States. It manifests itself in the arteries and can lead to myocardial infarction. Understanding the biological networks that underlie the complex interactions in coronary artery disease is required for disease prevention, diagnosis, and treatment.

PI_NAMEs: CIVELEK, METE  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;African ancestry;Allelic Imbalance;Anti-Hypertensive Agents;Aorta;Arterial Fatty Streak;Arteries;ARVCF gene;ascending aorta;Asian ancestry;Atherosclerosis;Bayesian Network;Biological;Biological Assay;Blood Vessels;calcification;causal variant;Cause of Death;Cell Culture Techniques;Cell Physiology;Cell Separation;cell type;Characteristics;Cholesterol;Chromatin;chromatin remodeling;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computational Biology;Coronary;Coronary Arteriosclerosis;Coronary artery;cytokine;Data;Diagnosis;Disease;Disease susceptibility;disorder prevention;disorder risk;Donor person;drug discovery;Early Diagnosis;Enhancers;Environmental Risk Factor;European ancestry;experimental study;gain of function;Gene Expression;Gene Expression Regulation;gene function;gene interaction;gene network;gene regulatory network;Genes;Genetic;genetic approach;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genotype;Goals;Heart Transplantation;Human;Human Resources;Immunohistochemistry;In Vitro;Individual;Inflammatory;Latinx;Lentivirus;Linkage Disequilibrium;Lipids;loss of function;Maps;Measures;migration;Modeling;Molecular;multi-ethnic;Myocardial Infarction;particle;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Process;Proliferating;Protein Analysis;Proteins;public health relevance;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Research;Resources;response;Risk;Risk Factors;RNA;Role;Series;Serum;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Specimen;Stimulus;Sudden Death;System;Testing;Time;Transcript;transcription factor;transcriptome sequencing;transdifferentiation;Translating;Transposase;United States;Untranslated RNA;Update;Variant;Vascular Smooth Muscle;Western World

PROJECT_TITLE: Systems Genetics of Vascular Smooth Muscle Phenotypes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative. The ability of cells and organisms to maintain metabolic homeostasis is fundamental to their health and long-term survival. This project will use recently developed tools to understand the role of a metabolic protein that has been shown to enhance health and longevity. The resulting data will help to understand how complex metabolic pathways are intertwined and how they can be leveraged to improve health outcomes.

PI_NAMEs: LEISER, SCOTT F (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Affect;age-related disease;Aging;Archaea;Biochemical Pathway;biological adaptation to stress;Biological Assay;Biology;Caenorhabditis elegans;Carbon;Cardiovascular Diseases;Cells;Collaborations;Communities;Complex;Data;Data Analyses;Dietary intake;dietary restriction;Disease;Drug Metabolic Detoxication;drug metabolism;endoplasmic reticulum stress;Energy Intake;Ensure;Environment;environmental intervention;Enzymes;Family;Fatty Acids;flavin-containing monooxygenase;FMO2;Food;gene therapy;Genes;Genetic;Genetic Epistasis;Goals;Health;Health Benefit;healthspan;Heavy Metals;Homeostasis;Homologous Gene;Human;improved;In Vitro;innovation;Intervention;knock-down;Knowledge;Kynurenine;Link;Lipids;Longevity;Longevity Pathway;Malnutrition;Measures;Mediating;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methylation;Methyltransferase;Modeling;Modification;Nature;Nematoda;novel;Organism;Outcome;Output;overexpression;Oxygen Isotopes;Oxygenases;Paraquat;Pathway interactions;Phase;Play;Process;Production;programs;Proteins;Publishing;Regulation;Reporting;Reproducibility;Research;Resistance;response;Role;Scientist;Source;Stress;success;System;targeted treatment;Techniques;Testing;therapy development;tool;Tryptophan;Work;Xenobiotics

PROJECT_TITLE: Flavin-containing monooxygenases in endogenous metabolism and aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Opioids;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Substance use disorders (SUDs) are prevalent, have a large societal impact worldwide, and are associated with many adverse psychological and health outcomes including increased rates of injury and elevated disease risk. The majority of individuals diagnosed with a SUD also meet diagnostic criteria for at least one additional SUD posing further psychiatric and medical risk; however, the ability to distinguish the genetic and biological risk for specific SUDs, and influences shared across co-occurring SUDs, remains limited. An advanced understanding of the genetic and neurobiological influences on real-world patterns of substance use, SUDs, and SUD co-occurrence has the potential to inform SUD intervention and treatment modalities.

PI_NAMEs: DEAK, JOSEPH D. (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Accounting;Address;alcohol use disorder;Architecture;Area;Attention;biobank;Bioinformatics;Biological;Biology;Cannabis;career;Clinical Informatics;Cocaine;cocaine exposure;Cocaine use disorder;Code;comorbidity;Control Groups;Data;Data Sources;Databases;Dependence;Diagnosis;Diagnostic;diagnostic criteria;disorder risk;Disparity;Dissection;Electronic Health Record;Epidemiology;Equation;Etiology;European ancestry;experience;Exposure to;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genome wide association study;genome-wide;Genomic Segment;Genomics;Health;health disparity;Heritability;improved;in silico;indexing;Individual;Injury;interest;Intervention;Investigation;K-Series Research Career Programs;Legal;marijuana use disorder;Medical;Modality;Modeling;Molecular;multidisciplinary;Neurobiology;novel;Opioid;opioid exposure;opioid use disorder;Outcome;Outcome Study;Participant;Pathway interactions;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;Phenotype;polygenic risk score;polysubstance use;Population Heterogeneity;prescription opioid;programs;psychogenetics;psychologic;Psychopharmacology;Race;racial disparity;racial diversity;Records;Reduce health disparities;Research;Research Design;Resolution;Risk;Risk Assessment;risk prediction;Sampling;screening;Screening Result;Severities;skills;social;social health determinants;Societies;sociodemographics;Specificity;Stimulant;substance use;Substance Use Disorder;Test Result;Testing;Time;Toxicology;Training;trait;Translations;Veterans;whole genome

PROJECT_TITLE: Using novel data sources across genetic, biological, and social domains to refine genome-wide investigations of substance use disorders

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing new combination strategies to treating bladder cancer which a common and lethal disease. This project will dissect the mechanisms by which tumor-associated macrophages drive resistance to current systemic therapies and will investigate the mechanisms of tumor-macrophage crosstalk that prevent immunogenic cancer cell death with the ultimate goal of developing more effective macrophage- directed strategies. Thus, the proposed research is relevant to the part of the NIH’s mission to lengthening life.

PI_NAMEs: DE CARVALHO, FILIPE  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acceleration;Advisory Committees;Antitumor Response;Award;base;Biological Markers;Biology;Bladder;Bladder Neoplasm;cancer cell;cancer genomics;Cancer Patient;cancer therapy;cancer type;career;career development;CD8B1 gene;Cell Death;Cells;checkpoint inhibition;checkpoint therapy;Chronic;Cisplatin;Clinical Treatment;Clinical Trials;Cytotoxic T-Lymphocytes;Dana-Farber Cancer Institute;Data;Development;Disease;DNA Damage;Effectiveness;effectiveness testing;Future;Goals;Hospitals;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune Targeting;Immuno-Chemotherapy;immunogenic;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;in vivo;Infiltration;Interferon Activation;Interferons;Invaded;K-Series Research Career Programs;Knowledge;Laboratories;Life;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mentors;Mission;mouse model;Mus;Muscle;next generation;novel;Oncologist;Outcome;Patients;permissiveness;Phenotype;Population Sciences;Positioning Attribute;Pre-Clinical Model;prevent;Program Development;programs;Property;Proteins;Public Health;randomized, clinical trials;recruit;Refractory;refractory cancer;Research;Research Personnel;Research Proposals;Resistance;response;Role;Scientist;Signal Induction;Signal Transduction;statistics;Surgeon;Systemic Therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic development;therapeutic target;Therapeutically Targetable;Time;Treatment Efficacy;tumor;tumor growth;tumor immunology;tumor microenvironment;Tumor-associated macrophages;United States National Institutes of Health;urologic;Urologist;Woman

PROJECT_TITLE: Tumor-Immune Interactions and Cisplatin Resistance in Bladder Cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Kidney Disease;Prevention;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Despite being one of the most common bacterial infections worldwide, the diagnostic strategies for urinary tract infections (UTI) are surprisingly insensitive, which can result in mistreatment. The proposed research will use human genomic data, gene expression data at single cell resolution, and UTI mouse models to find genetic risk factors associated with developing severe or recurrent UTI. These results will reveal novel genes and cell types that have antimicrobial properties in the kidney and bladder, which can lead to more precise UTI diagnoses and tailored therapeutics.

PI_NAMEs: XU, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adhesions;Affect;Antibiotic Resistance;antimicrobial;Atlases;Award;Bacteremia;Bacteria;Bacterial Infections;Bacterial Pili;Binding;Biochemical;Biological Assay;Bladder;Bladder Urothelium;Candidate Disease Gene;candidate identification;career;causal variant;Cell Line;Cell surface;cell type;Cells;Childbirth;cohort;Complement;Cystitis;Data;Data Set;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic tool;Epithelium;Escherichia coli;Exposure to;Fostering;functional genomics;Gene Expression;gene function;Genes;Genetic;genetic analysis;genetic approach;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Genomic approach;genomic data;genomic locus;Glycoproteins;Growth;host-microbe interactions;Human;Human Genetics;Human Genome;human tissue;Immune;immune activation;immune function;Immunosuppression;In Vitro;in vitro Assay;in vivo;Individual;Infection;Infiltration;Inflammatory Response;insight;Kidney;kidney cell;Kidney Diseases;kidney epithelial cell;kidney infection;Kidney Papilla;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Lead;Leadership;Life;malformation;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;maltreatment;Maps;Measures;men;Mentored Research Scientist Development Award;Mentorship;Messenger RNA;Methods;Modeling;Molecular;mouse model;multidisciplinary;multiple omics;Mus;novel;Outcome;Papillary;Pathogenesis;Patients;personalized therapeutic;Physiology;Play;precision medicine;Predisposition;prevent;Prevention strategy;Procedures;Property;Prostate;protective effect;Quantitative Trait Loci;Radioactive;Recurrence;Renal pelvis;Research;Resolution;response;Risk;Risk Factors;risk variant;RNA;RNA analysis;Role;Sampling;Scientist;sex;Sex Behavior;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;sugar;Susceptibility Gene;Suspensions;Testing;Therapeutic;Tissues;tool;Training;trait;transcriptomics;Transitional Epithelium;UMOD gene;Universities;UPK2 gene;urinary;Urinary tract;Urinary tract infection;Urine;urologic;Uropathogenic E. coli;Urothelium;Wild Type Mouse;Woman;Women's prevalence;Work;Writing

PROJECT_TITLE: Human Genetic Approach for UTI Points to Novel Immune Defense Cells of the Kidney Epithelia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Clinical Research;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rehabilitation;Vaccine Related

PHR: Project Narrative  Patients who have received joint replacement are at risk for periprosthetic joint infection, a serious condition which can lead to morbidity, disability, amputation, and even death. We will investigate how an injectable biomaterials-based vaccine system improves host immunity to prevent Staphylococcus aureus periprosthetic joint infection in murine and rabbit models. This project will lead to a better understanding of immunity in device- related infection and characterize a new vaccine modality.

PI_NAMEs: TATARA, ALEXANDER MITCHELL (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Abscess;adaptive immune response;adaptive immunity;Adjuvant;Affect;Amputation;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antigens;B-Lymphocytes;Bacterial Adhesion;Biocompatible Materials;biodegradable scaffold;Biological Assay;bioluminescence imaging;Biomedical Engineering;Biometry;Bolus Infusion;career;Cells;Cessation of life;Chemicals;Clinical;Clinical Trials;clinically relevant;Combination immunotherapy;cross immunity;cytokine;Data;Dendritic Cells;design;Development;Devices;disability;Disease;disease model;Ecosystem;efficacy evaluation;Engineering;Formulation;Functional disorder;functional restoration;Future;General Hospitals;Genetic;Glycobiology;Glycoproteins;Goals;High Prevalence;Human;Immune response;Immunity;immunoengineering;immunogenic;Immunology;Immunotherapy;Implant;improved;Individual;Infection;Injectable;innovation;Intravenous;Joints;Knowledge;Life;limb loss;Macrophage;Massachusetts;Measures;Mediating;Medicine;Mentors;Mentorship;Microbial Biofilms;Microbiology;Modality;Modeling;Molecular;Morbidity - disease rate;mouse model;multidisciplinary;Mus;mutant;Myeloid Cells;neutrophil;novel strategies;novel vaccines;Operative Surgical Procedures;Organism;Oryctolagus cuniculus;pain relief;pathogen;Patients;Pattern;Periprosthetic joint infection;Persons;Polysaccharides;prevent;Prevention;programs;rational design;recruit;Recurrence;Relapse;Replacement Arthroplasty;Research;Research Project Grants;research study;Resources;response;Risk;Role;scaffold;Science;Second Look Surgery;Sepsis;Site;skills;Source;Staphylococcus aureus;Staphylococcus aureus infection;stem cell biology;Surface;System;T cell response;T-Lymphocyte;Techniques;Technology;Time;Tissues;tool;Training;Treatment Failure;Universities;uptake;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine platform;Vaccines;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Biomaterials-based Immunoengineering for Periprosthetic Joint Infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE This study evaluates the cumulative effect of toxic stress from the neonatal intensive care unit (NICU) with maternal social determinants of health in preterm infant and maternal dyads. Measures of epigenetic alternations serve as a robust indicator of biologic changes secondary to toxic stress. These data are vital for the development and testing of much needed targeted stress reducing interventions that will improve long-term health and development in vulnerable dyads requiring NICU hospitalization.

PI_NAMEs: MALIN, KATHRYN JEANNE (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Accounting;Address;Appearance;Biological;biological adaptation to stress;Biological Factors;biological systems;Birth;brain circuitry;built environment;career;Cognitive;Complex;critical period;Data;Development;Discrimination;DNA;DNA Methylation;early experience;early life stress;Education;Enrollment;Environment;Epigenetic Process;experience;Exposure to;food security;Future;Genes;Glucocorticoids;Goals;Health;Health Care Costs;health determinants;Hospitalization;Household;Hypothalamic structure;improved;Income;Infant;Infant Development;Infant Health;Intervention;Investigation;Investments;Language;Life;Light;Link;longitudinal design;Longitudinal Studies;Maternal Health;Measures;Methylation;methylation pattern;model development;Modeling;Mothers;motor deficit;Neonatal;Neonatal Intensive Care Units;Neurologic;new therapeutic target;NR3C1 gene;Occupations;Pain;parental role;Patient Self-Report;perinatal period;Physiological;Physiological Adaptation;Physiology;Pituitary-Adrenal System;Pregnancy;Premature Birth;Premature Infant;presynaptic neurons;promoter;Promoter Regions;Questionnaires;Regulation;Research;response;Risk;Secondary to;Sensory;Serotonin;Social Environment;social health determinants;Social support;sound;Stimulus;Stress;stress reduction;stressor;success;Surveys;Swab;System;Testing;Time;Toxic effect;Training;uptake;Vision;Vulnerable Populations;Woman;World Health Organization

PROJECT_TITLE: PRemature Infants, Moms, and the Social determinants of health - an Epigenetic Investigation (PRIMS-EI)

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Delirium is a type of acute confusion experienced frequently by older adults after surgery or during critical illness that is associated with subsequent long-term cognitive impairment and increased risk for Alzheimer's Disease and Related Dementia. Yet, we currently lack drugs to prevent delirium due to a poor understanding of its underlying biological mechanisms. Using immunoassays and unbiased proteomics of cerebrospinal fluid obtained from older surgical and critically ill patients, the current study aims to test whether increased levels of activated complement proteins, a set of powerful inflammatory mediators, are associated with 1) postoperative delirium, 2) intensive care unit (ICU) delirium, and 3) post-ICU long-term cognitive impairment.

PI_NAMEs: DEVINNEY, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Active Learning;Acute;Admission activity;age related;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Behavior;biobank;Biological;Biological Assay;Biological Markers;Biology;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;career;career development;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;Cognition;cognitive testing;cohort;Complement;Complement Activation;complement pathway;Confusion;Conscious;Critical Care;Critical Illness;Data;Delirium;Dementia;design;Development;Development Plans;Disease;Educational workshop;Ethics;experience;Extramural Activities;FDA approved;follow-up;Functional disorder;Funding;Future;Goals;Grant;Hip Fractures;Hospitals;Hour;Human;Immune;Immunoassay;Impaired cognition;Individual;Inflammation;Inflammation Mediators;insight;Intensive Care Units;Knowledge;Lead;Link;Mass Spectrum Analysis;Matched Case-Control Study;Measures;Memory impairment;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;Molecular;Mus;neural;neuroimmunology;neuroinflammation;neuropathology;novel;older adult;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Pathway interactions;Patient Care;Patients;Perioperative;Peripheral;Phagocytosis;Pharmaceutical Preparations;Physicians;Play;postoperative delirium;Postoperative Period;prevent;Prospective cohort;Prospective, cohort study;Proteins;Proteomics;recruit;repository;Research;Research Proposals;Risk;Role;Sampling;Scientist;skill acquisition;skills;Spinal Puncture;Staging;Synapses;Syndrome;Testing;Training;Translational Research;Trauma;United States;Work

PROJECT_TITLE: The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M4)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementia (ADRD) cases are projected to rapidly expand in low- and middle- income countries in the coming decades and government cash transfer programs may be effective interventions. This proposal will address NIA strategic priorities by answering key questions about the amounts, durations, target recipients, and adult life course timing of cash transfer income necessary to reduce ADRD risk and explore potential mechanisms through household assets and spending on cognitively stimulating resources. Results will provide actionable evidence to inform the optimal design of cash transfer programs to support the health and longevity of the rapidly aging populations that they serve.

PI_NAMEs: KOBAYASHI, LINDSAY C;ROSENBERG, MOLLY SEARS (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adult;Aging;Alzheimer's disease related dementia;Cellular Phone;Censuses;Cognitive;Cognitive aging;cognitive reserve;Cohort Studies;Communication;Country;COVID-19 pandemic;Data;Data Linkages;Dementia;dementia risk;design;Economics;effective intervention;Eligibility Determination;emerging adult;Expenditure;follow-up;Food;Goals;Government;Health;Household;Impaired cognition;Incidence;Income;Individual;innovation;Intervention;Investments;Journals;knowledge base;late life;Life Cycle Stages;Link;Longevity;low and middle-income countries;Low income;Manuscripts;Maps;member;Memory Loss;men;mortality risk;neuroimaging;Neuropsychology;older adult;Outcome Study;Ownership;Paper;Participant;Policies;Population;Probability;programs;Publications;Publishing;Radio;Randomized;Recording of previous events;Research;Resources;Role;rural South Africa;Sampling;Social Medicine;Social Policies;Social Protection;Social Sciences;socioeconomics;Source;South Africa;South African;Testing;Transportation;United States;Woman

PROJECT_TITLE: Cumulative socioeconomic exposures, cash transfer interventions, and later-life cognitive decline and dementia risk in a low-income region of South Africa

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE We propose to revitalize research training in kidney, urologic and hematologic (KUH) science by creating a new program in the Northwest US: the Northwest COmprehensive Research Training in Kidney, Urologic and Hematologic Sciences (NCOR-KUH) Program. The VISION of the Program is to train the next generation of KUH scientists who will drive scientific innovation to improve the lives of patients with KUH diseases. To realize this vision, the MISSION of the Program is to create an integrated KUH scientific environment across five institutions (University of Washington, Fred Hutchinson Cancer Center, Seattle Children’s Hospital, Puget Sound VA and Bloodworks Northwest) to furnish trainees with world-class hands-on research training, mentorship, education, and networking to foster their personal and professional development.

PI_NAMEs: BANSAL, NISHA  (contact);KESTENBAUM, BRYAN R

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adult;Affect;Alaska;Basic Science;Benchmarking;Biomedical Research;Cancer Center;career development;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Sciences;Communities;community building;design;Development;Doctor of Philosophy;doctoral student;Ecosystem;Education;Educational Curriculum;Ensure;Environment;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Fostering;Funding;Future;Gender;Goals;Grant;hands on research;Hematological Disease;Hematology;High School Student;Idaho;implementation facilitation;improved;innovation;Institution;Interdisciplinary Study;International;Kidney;Kidney Diseases;Medical Education;Medical Students;Mentors;Mentorship;Methods;Mission;Montana;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Northwestern United States;Patients;Pediatric Hospitals;peer;Physicians;Population;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health;racial diversity;recruit;Research;Research Institute;Research Personnel;Research Training;Resources;rurality;Schools;Science;Scientist;sex;social;sound;Structure;Students;success;System;TNFSF15 gene;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;university student;urologic;Urologic Diseases;Urology;virtual platform;Vision;Washington;Woman;Work;Wyoming

PROJECT_TITLE: Northwest Comprehensive Research Training in Kidney, Urologic, and Hematologic Sciences (NCOR-KUH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-3 (M1)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PATHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: The proposed research is relevant to human health because it can directly benefit a group of cancer patients that currently have extremely poor prognosis by providing them with targeted treatment options that overcome chemotherapy resistance. Through development and testing of innovative research strategies with in vitro and in vivo models, these studies are directly in line with the mission of the National Institutes of Health; seek fundamental knowledge about living systems and apply that knowledge to enhance human health.

PI_NAMEs: HARRELL, JOSHUA (CHUCK)  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: advanced disease;Apoptosis;Apoptotic;Biological;Breast Cancer Cell;Bypass;cancer cell;Cancer Patient;Carboplatin;Cells;Cellular Stress;Cessation of life;Characteristics;Chemoresistance;Clinic;Clinical;Combined Modality Therapy;compare effectiveness;cytotoxic;cytotoxicity;Data Set;Development;Disease;Disease Management;Drug Combinations;efficacy evaluation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Estrogens;FDA approved;Genes;Genetic;Genomics;Goals;Growth;Health;Human;In Vitro;in vivo Model;Individual;inhibitor;innovation;Interferometry;Knowledge;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Mediator;Metastatic breast cancer;Mission;Modeling;molecular drug target;Neoplasm Metastasis;new therapeutic target;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organism;Outcome;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;pharmacologic;Prognosis;Proliferating;Proteomics;Receptor Inhibition;Research;Research Proposals;Resistance;response;safety testing;Sampling;Signal Pathway;Signal Transduction;Speed;spheroids;targeted treatment;Testing;Therapeutic;transcriptome sequencing;Translating;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;United States;United States National Institutes of Health;Unresectable;Work

PROJECT_TITLE: Circumventing acquired carboplatin resistance in triple-negative breast cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative (3 sentences max): Kidney stones represent a significant burden on the US healthcare system with approximately 10% of Americans suffering from this disease at some point in their life. The objective of this proposed body of work is to develop a nanotechnology based treatment that can specifically target kidney stones and cause stone comminution through irradiation with a low power near-infrared laser in a non-contact mode. This project will advance the career development of the investigator and provide the basis for the introduction of a paradigm changing treatment modality for urolithiasis.

PI_NAMEs: HOULIHAN, IAN  (contact)

PROJECT_TERMS: absorption;Acoustics;Address;Adverse reactions;Affinity;Aftercare;American;Amines;Anatomy;Animals;Area;Award;Binding;Biology;biomaterial compatibility;Calcium;Calcium Oxalate;carboxylate;career;career development;Career Mobility;Cell Survival;Clinic;Clinical;Clinical Treatment;Clinical Trials;Complex;Data;design;Development;Development Plans;Disease;Doctor of Philosophy;Educational workshop;effective therapy;Energy Transfer;Engineering;Ensure;experience;experimental study;Exposure to;Extracorporeal Shockwave Lithotripsy;Failure;Fatigue;Fiber;Funding;Goals;Gold;Health Care Costs;Healthcare Systems;Heat Stress;Histopathology;Human;In Vitro;in vivo;in vivo Model;innovation;inorganic phosphate;irradiation;Kidney;Kidney Calculi;Kidney Diseases;kidney imaging;Laser Lithotripsy;Lasers;Learning;Length;Life;Ligands;Light;Lithotripsy;Mechanical Stress;Medical;Mentors;Methods;microCT;Modality;Modeling;mouse model;nanoGold;nanomaterials;Nanotechnology;new technology;novel;Oxalates;Pathology;Patients;Persons;phosphonate;photonics;Photons;Pilot Projects;porcine model;pressure;Process;Property;Prostate Cancer therapy;Radiation;Radiation exposure;Reporting;Research;Research Personnel;Roentgen Rays;Safety;safety testing;Science;Shock;Site;skills;Source;Spectroscopy, Fourier Transform Infrared;Statistical Data Interpretation;Structure;Surface;Techniques;Technology;Testing;thermal stress;Tissues;Toxic effect;Toxicity Tests;Training;Travel;United States National Institutes of Health;Universities;urolithiasis;Urologic Diseases;Urothelial Cell;Visualization;Water;Work

PROJECT_TITLE: Use of gold-based photothermal nanomaterials for the comminution of kidney stones


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Infectious Diseases;Otitis Media;Pediatric;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Projective Narrative Pediatric otitis media poses a significant burden on our healthcare system: it is the fourth most expensive condition among children in the United States and impacts hearing and speech, leading to delays in cognitive development and school performance. This proposed project will study the effectiveness of surgical treatment of otitis media using a large multi-institutional database and a prospective cohort study; and form a multi- institutional pediatric otolaryngology clinical collaborative. Results and knowledge gained from this proposal will prepare the applicant to conduct future multi-institutional pragmatic trials to define optimal surgical otitis media management.

PI_NAMEs: DEDHIA, KAVITA  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 10 year old;Accident and Emergency department;Address;Adenoidectomy;Adjuvant;Adjuvant Study;Admission activity;Age;age effect;aged;analytical method;Antibiotics;autism spectrum disorder;Biological Models;career;career development;Child;Child Health;Childhood;Chronic;Chronic Disease;Clinic;Clinical;Clinical Research;Clinical Trials;cognitive development;comorbidity;comparative effectiveness;Comparative Effectiveness Research;cost;Data;Data Collection;Data Element;Data Set;Databases;design;Developmental Delay Disorders;Diagnosis;Down's Syndrome;Ear Diseases;Effectiveness;effectiveness evaluation;effectiveness study;Electronic Health Record;Environmental Risk Factor;evidence base;Exclusion;experience;Future;Goals;Guidelines;Health Personnel;Health Policy;Health system;Healthcare Systems;Hearing;hearing impairment;Heterogeneity;improved;Informatics;insight;Institution;International;Intervention;Intratracheal Intubation;K-Series Research Career Programs;Knowledge;Learning;Measures;media use;Medical;Medical Informatics;Mentors;Mentorship;Methods;nasal obstruction;Nose;Operative Surgical Procedures;Otitis Media;Otolaryngologist;Otolaryngology;Outcome;Outcome Measure;Outcomes Research;Parents;patient oriented;Patient Outcomes Assessments;Patient Recruitments;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Pediatric Surgical Procedures;Pennsylvania;Performance;Philadelphia;Policy Research;Pragmatic clinical trial;pragmatic trial;Preparation;primary care visit;primary outcome;Procedures;professor;Program Development;programs;prospective;Prospective, cohort study;Quality of life;Questionnaires;randomized trial;Randomized, Controlled Trials;Recurrent disease;Repeat Surgery;Reporting;Reproducibility;Research;Research Design;Research Personnel;Risk;Role;Schools;Scientist;secondary outcome;Site;skills;social;sociodemographics;Speech;Speech Delay;Statistical Data Interpretation;statistics;Surgeon;surgery outcome;Surgical Management;surgical risk;Symptoms;Time;Training;treatment effect;Tube;Tympanostomy;United States;Universities;urgent care;Urologic Diseases;Urology;Visit

PROJECT_TITLE: The Effectiveness of Adjuvant Adenoidectomy in Surgical Management of Otitis Media

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE We propose to purchase and install pens for breeding pigtail macaques in our Seattle facility. Housing in pens rather than cages will increase animal welfare, thus improving the research model. This proposal will also decrease overall costs and increase animal availability for research projects.

PI_NAMEs: HOTCHKISS, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Address;Adolescent;animal breeding;Animal Experimentation;Animal Housing;Animal Model;Animal Welfare;Animals;Arizona;Behavioral Research;Biomedical Research;Breeding;cost;Cost Savings;environmental enrichment for laboratory animals;Female;Floor;Height;Housing;improved;Individual;Lead;Link;Macaca;Macaca nemestrina;male;Modeling;Monitor;nonhuman primate;Partner in relationship;pregnant;Primates;Production;programs;reproductive;Research;Research Personnel;Research Project Grants;Schedule;Site;Social Interaction;Socialization;Time;Wait Time;Washington;Weaning;welfare;Well in self

PROJECT_TITLE: Housing to Improve Welfare for M. nemestrina Breeding Colony at the WaNPRC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Neuronal cell polarity is a prerequisite for its unique function in receiving and relaying electrochemical signals, yet we lack a basic understanding of how it is achieved. We will combine human induced pluripotent stem cells (hiPSCs) and high-resolution cryo-electron tomography to investigate the role of biomolecular condensates proposed to impact the organization of the early secretory pathway in polarized neurons. Our approach will provide an unprecedented insight into the molecular organization of secretory hubs in neurons, and may uncover how neuronal cell polarity is established and maintained.

PI_NAMEs: ERNST, ANDREAS MAX (contact);VILLA, ELIZABETH

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Anabolism;Anatomy;Architecture;ARNT gene;Attention;automated segmentation;Axon;base;Biological Assay;Carbohydrates;Cell membrane;Cell Physiology;Cell Polarity;Cell surface;Cells;Cellular Structures;Chimeric Proteins;Communities;computerized tools;Cryo-electron tomography;Cryoelectron Microscopy;Cryopreservation;Cytosol;Data Set;Dendrites;Diameter;Dimensions;Electron Microscopy;Elements;Endoplasmic Reticulum;Ensure;Equipment and supply inventories;Exclusion;Exhibits;Face;flexibility;Fluorescence;Fluorescence Microscopy;Goals;Golgi Apparatus;golgin;Hela Cells;human induced pluripotent stem cells;In Situ;Individual;innovation;insight;Ions;Ischemic Stroke;Knowledge;Label;Lentivirus;Light;light microscopy;Lipids;Liquid substance;Membrane;Membrane Lipids;Microscopy;Molecular;Morphology;nanoscale;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal cell body;Neuronal Dysfunction;Neurons;Nuclear;Parkinson Disease;Pathogenesis;Pathway interactions;Peripheral;Phase;Physical condensation;pluripotent stem cell differentiation;polarized cell;Process;protein biomarkers;Proteins;Proteome;receptor;Recombinants;reconstruction;Research;Resolution;Ribosomes;Role;Route;segregation;self organization;Signal Transduction;Site;Stroke;Structure;superresolution microscopy;Surface;Thinness;Transfection;transmission process

PROJECT_TITLE: In situ cryo-EM of protein condensates in the early secretory pathway of neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-L (96)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Palliative Care;Precision Medicine;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Patients with triple-negative breast cancer (TNBC) undergo rigorous treatment regimens yet frequently experience high cancer recurrence rates and cancer death, leading to uncertainty, distress, and poor quality of life. The proposed research project aims to develop, refine, and pilot test a nurse-led, coping, and supportive care intervention for patients with TNBC during the critical transition from curative therapy to surveillance, designed to alleviate distress, improve quality of life, and increase stress-coping skills. By focusing on this previously understudied high-risk group of patients with breast cancer, study findings will inform future research utilizing risk-stratified survivorship care models with potential applications to other high-risk cancer survivors.

PI_NAMEs: POST, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Advanced Practice Nurse;Advisory Committees;American Cancer Society;American Society of Clinical Oncology;Anxiety;Area;Attention;behavior change;Behavior Therapy;Behavioral;Biometry;Black race;breast cancer diagnosis;Breast Oncology;cancer care;cancer recurrence;Cancer Survivor;Cancer Survivorship;care delivery;career development;Caring;Cessation of life;Client satisfaction;Clinical;clinically significant;Cognitive Therapy;Communities;coping;Coping Skills;curative treatments;Data;design;Discipline of Nursing;Disease;Distress;DNA Sequence Alteration;Doctor of Philosophy;Education;Emotional;Enrollment;Equity;ERBB2 gene;Estrogen receptor positive;evidence base;experience;Feedback;Feeling;Fellowship;Five-Year Plans;Foundations;Fright;Funding;General Hospitals;Goals;group intervention;Growth;Healthcare Systems;high risk;high risk population;High-Risk Cancer;Hispanic;hormone receptor-positive;hormone therapy;improved;improved outcome;innovation;instructor;International;Intervention;Interview;Journals;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Massachusetts;medical schools;meetings;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Nurses;Oncology;Outcomes Research;Participant;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Peer Review;Personal Satisfaction;Phase;Pilot Projects;pilot test;Population;Positioning Attribute;Postdoctoral Fellow;preference;Prognosis;prognostic;programs;Protocols documentation;psychosocial;psychosocial outcome;Publishing;Quality of life;Questionnaires;Randomized, Controlled Trials;Recommendation;Recurrence;reduce symptoms;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Risk;Risk Reduction;risk stratification;satisfaction;Scientist;secondary outcome;skills;Stress and Coping;Structure;Supportive care;Survival Rate;Survivors;survivorship;symposium;Symptom Burden;symptomatic improvement;targeted treatment;Testing;therapy development;Time;Training;Treatment Protocols;trial design;triple-negative invasive breast carcinoma;Uncertainty;usual care arm;Well in self;Woman;Work

PROJECT_TITLE: A Nurse-Led, Coping and Supportive Care Intervention to Improve Psychosocial Outcomes of Patients with Triple-Negative Breast Cancer During the Transition from Curative Therapy to Surveillance


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Sleep Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: Narrative Deficient sleep may contribute to cigarette smoking by aggravating negative mood and reducing self-control. We investigate the effects of a cognitive behavioral treatment of sleep deficiency on improving mood, self- control, and cessation outcomes. With brain imaging we also investigate the brain mechanisms underlying the effects of the treatment.

PI_NAMEs: FUCITO, LISA M;LI, CHIANG-SHAN RAY (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Adult;Animals;Anxiety;attentional bias;basal forebrain;Basal Nucleus of Meynert;behavioral sleep intervention;Biochemical;Brain;Brain imaging;Brain region;Caring;Cerebral cortex;Cerebrum;cholinergic;Chronic;Cigarette;cigarette smoking;Clinical;cognitive benefits;cognitive control;cognitive task;Cognitive Therapy;cohort;cost;cost outcomes;Counseling;Cues;Electric Stimulation;Emotional;Emotions;Exposure to;Face;Food;frontal lobe;Functional disorder;Hippocampus;Hypothalamic structure;imaging study;Impairment;improved;improvement on sleep;Impulsivity;Individual;Insula of Reil;Interruption;Lead;Link;Magnetic Resonance Imaging;Measures;Medial;Mental Depression;Moods;motivated behavior;negative mood;nerve supply;neural;neuromechanism;Neurons;Neurosciences;Nicotine;Nicotine Dependence;Outcome;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Prefrontal Cortex;Prevalence;Prosencephalon;psychologic;Randomized;Reaction Time;recruit;relapse prediction;relapse risk;remediation;Reporting;Research;response;Rewards;Schedule;Self-control as a personality trait;Severities;sex;Signal Transduction;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Wake Cycle;Sleeplessness;Smoke;Smoker;Smoking;smoking cessation;smoking cue;smoking prevalence;smoking relapse;Somatosensory Cortex;standard care;Stimulus;success;System;Task Performances;Testing;Time;Tobacco Use Disorder;treatment effect;varenicline;Variant;Withdrawal Symptom;Woman;Work

PROJECT_TITLE: Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse: An RCT of CBT for Insomnia in Adults who Smoke

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 BSW-N (M1)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to ethical, legal, and social implications of genomic information sharing as it focuses on evaluating information models which support stewardship of biospecimens and data – including genomic information. This work has the potential to account for a variety of expressions of biospecimen contributors’ preferences and values, as expressed in consent forms, and promotes transparent and ethical use of downstream applications such as those leveraging machine learning and artificial intelligence approaches. Thus, the proposed research is relevant to the goals of the National Human Genome Research Institute’s Ethical, Legal and Social Implications Research Program, including their focus on research for Genomic Research Design and Implementation, specifically in Data Science and Data Sharing.

PI_NAMEs: MCGOWAN, MICHELLE L (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Agreement;Area;Artificial Intelligence;authority;Authorization documentation;Belief;biobank;Clinic;Consent;Consent Forms;Contracts;Data;data management;data resource;data reuse;Data Science;data sharing;design;Ensure;ethical, legal, and social implication;Ethics;FAIR principles;Foundations;genomic data;Genomics;Goals;Grant;Health;improved;Individual;information model;Information Resources;Information Systems;innovation;interoperability;Label;Link;Machine Learning;Metadata;Modeling;National Human Genome Research Institute;Outcome;Persons;Policies;preference;Process;programs;public repository;Regulation;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;Risk;risk sharing;Role;Science;Semantics;Source;Specimen;Standardization;Technology;Testing;Trust;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: YOU GAVE CONSENT BUT DO I HAVE PERMISSION?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The Rutgers University New Jersey Medical School is requesting funds for the installation of an integrated automatic watering system (AWS) from Avidity Sciences to meet the needs of the expanding rodent facility. The Integrated system consists of a Chlorination system and a distribution system to deliver clean drinking water directly to the rodent cages. This system will benefit the research of over 42 NIH funded investigators by delivering constant and consistent supply of high quality water with precision, thus, ensuring reproducibility of results in our highly sensitive animal disease models; creating a significant gain in efficiency of operations, reduced costs and save staff time; reduce repetitive motion injuries in staff members; and providing “Green Energy” savings by eliminating the use of excess water, non-recyclable plastic water bottles and disposable plastic bags that are currently used in the facility.

PI_NAMEs: SINGH, BHUPINDER  (contact)

PROJECT_TERMS: Accreditation;animal care;Animal Disease Models;animal facility;Animal Model;Animal Sources;Animal Technicians;Animal Welfare;Animals;Avidity;Biomedical Research;Cancer Center;care systems;Cellular Phone;Censuses;chlorination;Chlorine;Cities;Consumption;Contracts;cost;Cost Savings;Cumulative Trauma Disorders;density;Dental Schools;design;Dimensions;drinking water;Ensure;Equipment;ergonomics;experience;Floods;Flushing;Friends;Funding;Future;Grant;Housing;improved;Individual;Infrastructure;Injury;Maintenance;medical schools;Medicine;member;Modernization;Monitor;multidisciplinary;Mus;New Jersey;operation;Osmosis;Output;pressure;Process;programs;Pump;Rattus;remote monitoring;Repression;Reproducibility;Reproducibility of Results;Research;Research Activity;Research Personnel;Research Support;Rodent;Savings;Science;Side;Signal Transduction;Source;Stainless Steel;System;Systems Integration;Technology;Time;United States National Institutes of Health;Universities;ventilation;Water;water flow;water quality;worker safety

PROJECT_TITLE: Automatic Watering System for the Cancer Center animal facility at New Jersey Medical School


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Despite the importance of a timely Alzheimer’s disease (AD) diagnosis, AD is underdiagnosed in real-world community settings, particularly in understudied populations. Our objectives are to identify undiagnosed AD in non-Hispanic white, Hispanic/Latino, and non-Hispanic African American groups utilizing disease trajectories and genetics followed by validation and replication. Our contributions will enable the application of disease trajectories in precision medicine and future work to reduce the bias of underdiagnosis in understudied populations.

PI_NAMEs: CHANG, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Address;African American;African American population;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;California;Clinical Data;Clinical Treatment;cohort;community setting;comorbidity;comparison control;Complement;computerized tools;Data;Dementia;Detection;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Pathway;Disparity;Economic Burden;Electronic Health Record;Ethnic Population;Evolution;Future;Genetic;genetic variant;genomic tools;Goals;Health;Health behavior;Health system;healthcare burden;hearing impairment;Hispanic;Hypertension;improved;Individual;Latino;Link;Longitudinal cohort study;Los Angeles;Machine Learning;machine learning model;Methods;Mining;Modeling;Neurodegenerative Disorders;Not Hispanic or Latino;Outcome Measure;Patients;Population;precision medicine;predictive modeling;Prevalence;Publications;racial population;research clinical testing;Resources;Risk;Risk Factors;Symptoms;Testing;Time;Universities;Validation;Work

PROJECT_TITLE: Identifying Undiagnosed Alzheimer’s Disease in Understudied Populations

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Post stroke cognitive impairment (PSCI) is a frequent complication experienced by stroke survivors and yet there remain gaps in both fundamental knowledge of how cerebral vascular contributions to dementia interact with likely preexisting neurodegenerative burdens among stroke survivors and practical decision support tools to aid in clinicians in prognosticating and managing PSCI to optimize stroke recovery and prevention of recurrent stroke. This project addresses these two gaps by developing novel machine learning algorithms to process a large and ethnically diverse routine clinical neuroimage and electronic health record dataset to predict PSCI and also assess, through a prospective study, added benefits of incorporating novel physiological and biological metrics of cerebrovascular and neurodegenerative underpinnings.

PI_NAMEs: HU, XIAO  (contact);NAHAB, FADI BASIL;QIU, DEQIANG

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;acute care;acute stroke;Address;Adopted;Algorithms;Alzheimer's disease pathology;Alzheimer's disease related dementia;axon injury;Biological;Biological Markers;Blood Flow Velocity;blood pressure control;Caring;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Characteristics;Clinic;Clinical;Clinical Data;clinical practice;Cognitive;cognitive testing;cohort;comorbidity;Complication;Data;Data Element;Data Set;Deterioration;Disparate;Distal;Electronic Health Record;electronic health record system;ethnic diversity;Etiology;experience;follow-up;Geography;Healthcare;high risk;Hybrids;Image;improved;indexing;Injury;Investigation;Ischemia;ischemic injury;Ischemic Stroke;Kansas;Knowledge;Label;Learning;learning algorithm;Lesion;Light;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;Measurement;Measures;Medical center;Modeling;Morphology;Nerve Degeneration;neurofilament;neuroimaging;neurovascular coupling;novel;Pathology;Patient Compliance;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physiologic pulse;Physiological;Plasma;post stroke;post stroke cognitive impairment;pre-trained model;predictive modeling;Prevention strategy;Process;prognostication;prospective;Prospective cohort;Prospective Studies;Race;Recurrence;recurrence prevention;Research;research study;risk mitigation;risk prediction;Role;screening;Severities;Signal Transduction;socioeconomic diversity;Stroke;stroke patient;Stroke prevention;stroke recovery;stroke survivor;support tools;targeted biomarker;Test Result;Testing;training data;Universities;Vascular Cognitive Impairment;Vascular Dementia;Visit

PROJECT_TITLE: Using AI on Routine Clinical and Imaging Data from Acute Stroke Encounter to Predict Post-Stroke Vascular Contributions to Cognitive Impairment (AI - RESPECT)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Changes in Medicare coverage for telehealth during the COVID-19 pandemic may have long-standing effects on the delivery of care at the end of life (EOL) to NH residents with Alzheimer's disease and Alzheimer's disease-related dementias (ADRD). This project will examine patterns of telehealth provision for NH residents at the EOL, particularly for palliative care, advance care planning, and hospice use, and the association between telehealth access and the quality and cost of care for NH residents, by race/ethnicity, dual eligibility, and rurality. The results will provide critical evidence for clinicians, payers, and policymakers on the uptake, applications, and impacts of telehealth use for NH residents with ADRD at the EOL.

PI_NAMEs: YU, JIANI  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Advance Care Planning;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;beneficiary;Budgets;care costs;care delivery;care systems;Caregivers;Caring;Cessation of life;Characteristics;Chronic;Cognitive;Complex;cost;COVID-19;COVID-19 pandemic;Cues;Disease;Disparity;disparity reduction;dual eligible;Emergency department visit;end of life;end of life care;Enrollment;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;Face;Fee-for-Service Plans;flexibility;gaps in access;Goals;Health Benefit;health care availability;Health Care Costs;health care disparity;health care service utilization;Health Policy;Health Services;Home Nursing Care;hospice utilization;Hospitalization;Hospitals;human old age (65+);Impaired cognition;Improve Access;improved;Individual;innovation;Judgment;Life;Long-Term Care;Measures;Mediating;Medical;medical specialties;Medicare;Modality;Natural experiment;nursing care quality;nursing home length of stay;Nursing Homes;older adult;outcome disparities;Pain management;Palliative Care;pandemic disease;patient oriented;Patients;Pattern;payment;Persons;Phase;Physicians;Policies;Policy Maker;Process Measure;programs;public health emergency;Quality of Care;Quasi-experiment;Race;racial disparity;racial minority;remote grading;remote health care;remote monitoring;Research;rural planning;rurality;screening;Self Care;Service setting;Services;Severities;socioeconomic disadvantage;socioeconomic disparity;Supervision;telehealth;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;uptake;Visit;Visiting Nurse;Visual;Vulnerable Populations;waiver

PROJECT_TITLE: Telehealth Use and the Quality of End-of-Life Care for Nursing Home Residents with Alzheimer's Disease and Alzheimer's Disease-Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE The majority of the over 1 million people in the United States living with Parkinson's disease and related disorders (PDRD) such as Lewy-body dementia (the second most common degenerative dementia after Alzheimer's disease), are cared for by medically untrained family members. Though Lewy-body dementia is specifically named by NIH as an Alzheimer's and Related disorder (ADRD) and an area of high priority research, there has been minimal research of care resources and support for these carepartners who face physical, emotional, spiritual, and financial challenges. To engage relevant targets to improve carepartner wellbeing, support, and preparedness, this proposal will use stakeholder engagement research methods to identify the dimensions and positive and negative aspects of caregiving, and partner with former PDRD carepartners, adapt, design, and conduct a pilot randomized control trial of the peer-led Competence, Autonomy, Relatedness, and Connections (CARe Connections) intervention that targets what matters most to PDRD carepartners.

PI_NAMEs: SESHADRI, SANDHYA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Adult women;Affect;Age;Alzheimer's Disease;Alzheimer's disease caregiver;Area;autism spectrum disorder;behavior change;behavior influence;Behavioral Model;caregiving;Caring;Chronic Disease;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Competence;Dementia;dementia care;dementia caregiving;Dementia with Lewy Bodies;design;Dimensions;Disease;Distress;Emotional;experience;Family member;feasibility trial;Goals;Hallucinations;Health;high risk;improved;innovation;International;Intervention;intervention delivery;Knowledge;Learning;lens;Lewy Body Dementia;Medical;men;Mental Health;Mentors;Methods;Mind;Modeling;Motivation;multidisciplinary;Names;Neurodegenerative Disorders;Neurology;older adult;Outcome;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;peer;Perception;person centered;Personal Satisfaction;Persons;Population;Population Intervention;programs;Publications;Qualifying;Qualitative Research;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Research;Research Methodology;Research Personnel;Research Priority;Research Proposals;Research Training;Resources;Self Determination;skills;social;Social isolation;Spirituality;Spouses;Testing;theories;therapy design;therapy development;Training;United States;United States National Institutes of Health;user centered design;Volition;Woman

PROJECT_TITLE: Competence, Autonomy, Relatedness, and Connections (CARe Connections): A Peer-Led Intervention Designed with Parkinsons Disease & Related Disorders Carepartners to Improve Holistic Support

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative JC virus is a human polyomavirus which infects and establishes lifelong infections in upwards of 70% of the human population. While JCV is considered to pass through the oral/fecal route, its primary site of infection has remained elusive. In this proposal we will address how JCV interacts with the gastrointestinal tract which will allow us to better understand, in the long term, how this interaction impacts the establishment of a lifelong infection of the kidneys.

PI_NAMEs: BOULANT, STEEVE ;STANIFER, MEGAN L (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Adult;Appearance;Autoimmune Diseases;Biopsy;Brain;Cell Line;cell type;Cells;Cellular Tropism;central nervous system demyelinating disorder;chronic infection;Colon;Colon Carcinoma;Consensus;contaminated water;Data;Disease;Duodenum;early childhood;Enteral;enteric infection;Enterocytes;Epithelial Cells;Excretory function;Feces;Food;Funding;gastrointestinal;Gastrointestinal tract structure;Goblet Cells;HIV;Human;ileum;Immune;Immunocompetent;Immunocompromised Host;Immunosuppression;Immunosuppressive Agents;Individual;Infection;Infection prevention;Infiltration;Ingestion;innovation;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;JC Virus;jejunum;Kidney;kidney infection;Knowledge;latent infection;Life Cycle Stages;Lytic;Myelin;neglect;novel therapeutics;Oligodendroglia;Oral;Oral Ingestion;Organ Transplantation;Organoids;Outcome;Pathogenesis;Patients;Persons;Pharmacologic Substance;Phase;Play;Polyomavirus;Population;Predisposition;prevent;Prevention strategy;Production;Progressive Multifocal Leukoencephalopathy;Research;Risk;Role;Route;secondary infection;seropositive;Shellfish;Site;stem cells;Supporting Cell;Surveys;System;Testing;Time;Tissues;transcytosis;transmission process;Tropism;urinary;Urine;Viral Genome;Viral Pathogenesis;Virion;Virus;Virus Diseases;Virus Replication;Virus Shedding;Work

PROJECT_TITLE: Using human intestinal organoids to evaluate JCV fecal/oral transmission

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Palliative Care

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: The proposed study will leverage data collected in a completed randomized clinical trial (D- CARE) to examine end-of-life care for persons living with dementia—outcomes not included in the original trial. The large number of decedents in D-CARE provides a unique opportunity to study how community-dwelling persons with dementia die and compare end-of-life outcomes between two effective dementia care management interventions. Completion of these new aims will provide greater insight into how best to care for PLWD near the end of life, including information about end-of-life care preferences, met or unmet care needs near death, and healthcare utilization in the last 6 months of life.

PI_NAMEs: JENNINGS, LEE ALEXANDRA (contact)

PROJECT_TERMS: Acute;American;Behavioral Symptoms;care costs;care preference;caregiver strain;Caregivers;Caring;Cessation of life;Clinical;Communication;Communities;comparative effectiveness;comparison intervention;cost effectiveness;Data;Data Collection;Dementia;dementia care;Dialysis procedure;Documentation;electronic health data;Electronic Health Record;Emergency department visit;end of life;end of life care;end of life outcomes;Enrollment;Enteral Feeding;Ethnic Origin;Family;Family Caregiver;Friends;Funding;Goals;group intervention;health care service utilization;Health system;Healthcare;Home;hospice utilization;Hospitalization;Hospitals;improved;insight;Intervention;intervention effect;Intubation;Knowledge;Life;Location;Managed Care;Medicare;Medicare claim;Modeling;National Institute on Aging;Nursing Homes;nutrition;Outcome;Outcome Assessment;Palliative Care;Participant;Patient-Focused Outcomes;Persons;preference;primary outcome;programs;Quality of Care;quality of death;Race;randomized, clinical trials;recruit;Reporting;Research;Research Institute;Resuscitation;retention rate;Site;Specific qualifier value;Surveys;symptom management;three-arm trial;Time;treatment arm;treatment as usual

PROJECT_TITLE: D-CARE End of Life Study


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Schizophrenia

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative  Deficits in cognitive behavioral flexibility lead to disability and pose barriers to recovery in many mental disorders, including schizophrenia, autism, post-traumatic stress disorder, and dementias, but these symptoms are largely unaddressed by conventional pharmacologic or somatic therapies. To develop new ways of intervening to improve or even prevent these neurocognitive impairments, we must better understand the underlying brain circuits, their networking, and how they coordinate their activity. This research proposal will identify brain circuits and specific neurochemical signals facilitating flexible learning and adaptive behavior, with the long-term goal of advancing the development of new treatments for neurocognitive disorders.

PI_NAMEs: VILLARIN, JOSEPH MANUEL (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acetylcholine;Adaptive Behaviors;Address;Advanced Development;Amygdaloid structure;Animals;Area;Association Learning;autism spectrum disorder;Back;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;Biosensor;Brain;career;career development;Cellular biology;cholinergic;cholinergic neuron;Cognitive;Computer Analysis;Computer Models;Computing Methodologies;Data;Data Set;Decision Making;Dementia;Diagnosis;Dimensions;disability;Disparate;Doctor of Philosophy;empowerment;Environment;expectation;experimental study;feeding;Fiber;flexibility;Foundations;Funding;Future;Goals;Impaired cognition;Impairment;improved;Infusion procedures;inhibitor;innovation;Intervention;Lateral;Lead;learned behavior;Learning;Lesion;Literature;Measurable;Measures;Mental disorders;Mentors;Modeling;Molecular Biology Techniques;Mus;Muscarinic Acetylcholine Receptor;neural;neurochemistry;Neurocognitive Deficit;neurocognitive disorder;Neurons;Neurosciences;new therapeutic target;New York;optogenetics;Outcome;Pathway interactions;Patients;Persons;pharmacologic;Photometry;Physicians;Physiology;Positioning Attribute;Post-Traumatic Stress Disorders;predictive modeling;prevent;Process;Productivity;Program Development;Psychological reinforcement;Recording of previous events;Recovery;Reporting;Research;Research Proposals;Reversal Learning;Rewards;Rodent;Role;Schizophrenia;Scientist;Signal Transduction;skills;Stimulus;Symptoms;Synapses;Testing;Time;tool;Training;Transcend;Translational Research;Uncertainty;Universities

PROJECT_TITLE: Discrete Functions of Basal Forebrain Cholinergic Signaling to Amygdala and Orbitofrontal Cortex in Reversal Learning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_DEPT: PHARMACOLOGY

PHR: There remains a critical need to both explore novel therapeutic approaches and timing of the intervention that could clinically impact Alzheimer’s disease (AD). Immune alterations are linked to AD risk and pathology. Here, we propose to evaluate multiple immune manipulations that could inform on novel approaches to harness the immune system for benefit in AD.

PI_NAMEs: GOLDE, TODD E (contact);LEVITES, YONA R;ROWAN, MATTHEW J.M.

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid deposition;amyloid pathology;Benchmarking;Benefits and Risks;Biological;Biological Assay;Biology;Brain;brain cell;Chimeric Proteins;Clinical;Clinical Trials;clinically relevant;Coupled;Data;Deposition;design;Disease;Equilibrium;experience;falls;Functional disorder;Genetic;Genetic study;genetic variant;Goals;Health system;Human;Immune;immune activation;immune checkpoint;Immune response;Immune signaling;Immune system;Immune Targeting;Immunomodulators;immunomodulatory strategy;immunomodulatory therapies;Immunooncology;immunoregulation;Immunosuppression;improved;innate immune pathways;Innate Immune System;insight;Intervention;Link;Malignant Neoplasms;Measures;Mediating;Microglia;Mind;Modification;mouse model;multiple omics;Mus;Natural Immunity;Nervous System;Neurodegenerative Disorders;Neuroimmune;novel;novel strategies;novel therapeutic intervention;Passive Immunotherapy;Pathologic;Pathology;Pathway interactions;Pre-Clinical Model;preclinical study;Process;Proteins;Proteomics;receptor;Recombinant adeno-associated virus (rAAV);Risk;Role;Science;sex;Signal Pathway;Study models;Surveys;Synapses;synaptic function;synaptic pruning;System;Tertiary Protein Structure;Testing;Therapeutic;Toxic effect;transcriptomics;transgene delivery;vector

PROJECT_TITLE: Searching for the Goldilocks Zone of  Innate Immunity in Alzheimer's Disease

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Although current behavioral weight loss treatments achieve clinically significant weight loss and corresponding health benefits, most participants regain their weight soon after treatment. The proposed project will test the feasibility, acceptability, and preliminary effectiveness of using just-in-time adaptive interventions (JITAIs) that facilitate mindfulness, acceptance, and self-compassion to help participants respond more adaptively to small weight regains and ultimately, achieve better long-term weight control. If effective, these interventions can be used as an easily disseminable, low-cost supplement to behavioral weight loss treatment.

PI_NAMEs: HAGERMAN, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;active control;adaptive intervention;Address;Adherence;Adult;Aftercare;attentional control;Behavior;Behavior Control;Behavioral;behavioral response;Benchmarking;Biological Factors;Body Weight;Body Weight decreased;Calories;cardiovascular disorder risk;Clinical Trials;clinically significant;Cognition;coping;cost;design;Distress;Ecological momentary assessment;Effectiveness;effectiveness testing;Environmental Risk Factor;expectation;experience;Failure;feasibility testing;Feedback;Frustration;Future;Goals;Health Benefit;healthy weight;improved;Individual;Intervention;intervention cost;intervention program;Long-Term Effects;Maintenance;mindfulness;mobile application;Motivation;Obesity;Overweight;Participant;participant enrollment;Persons;Physical activity;prevent;Problem Solving;Process;programs;promote resilience;psychologic;Psychological Factors;psychological neglect;Randomized;recruit;Reporting;Research;response;Rest;Risk;satisfaction;Self Efficacy;self-compassion;Shame;social factors;success;Testing;Therapeutic;Time;Use Effectiveness;Weight;Weight Gain;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: Testing just-in-time adaptive interventions (JITAIs) to prevent goal disengagement in response to weight regain following behavioral weight loss treatment

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Estrogen;Eye Disease and Disorders of Vision;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Children with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome develop optic pathway gliomas (OPGs), which can cause retinal ganglion cell (RGC) death and vision loss. In an effort to identify new therapies to reduce vision loss, we aim to define the mechanisms that cause RGC death using mouse models of Nf1-OPG.

PI_NAMEs: TANG, YUNSHUO CAROLINE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Ablation;Adult;Advisory Committees;Affect;Agonist;Apoptosis;Astrocytoma;Attenuated;Axon;Basic Science;Biological Assay;Blindness;boys;Brain;Brain Neoplasms;cancer predisposition;career;career development;Cell Death;Cell Density;cell injury;Cell Survival;Cessation of life;Characteristics;Chemicals;chemotherapy;Child;Chronic;Clinical;Collaborations;Communication;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Development;Development Plans;Disease;Doctor of Philosophy;Estrogen Activity Inhibition;estrogen disruption;Estrogens;Etiology;Exhibits;experience;Experimental Designs;experimental study;Eye diseases;Female;Foundations;Functional disorder;Funding;Future;ganglion cell;Genetic;girls;Glioma;Goals;Gonadotropin Hormone Releasing Hormone;Human;human disease;Hydrolysis;Impairment;improved;In Vitro;in vivo;Incidence;Inflammatory;inhibitor;Injury;instructor;Interleukin-1 beta;Laboratories;Leadership;male;Measures;Mediating;Mediator;Mentorship;Molecular;mouse model;Mouse Strains;Mus;mutant;Nerve Degeneration;Nervous System Disorder;Neurofibromatosis 1;Neuroglia;Neurology;Neuronal Injury;neuroprotection;neurotoxic;neurotoxicity;neutralizing antibody;NF1 gene;NF1 mutation;novel therapeutics;Operative Surgical Procedures;Ophthalmologist;Optic Nerve;optic nerve disorder;Optic Nerve Glioma;Optic Nerve Injuries;Optics;Ovariectomy;overexpression;Pathology;Pathway interactions;Patients;pharmacologic;phosphodiesterase IV;Phosphorylation;Positioning Attribute;preclinical evaluation;preclinical study;Production;Protein Inhibition;protein kinase inhibitor;restoration;Retina;Retinal Ganglion Cells;retinal nerve fiber layer;Risk;Seminal;sex;sexual dimorphism;sight restoration;Signal Transduction;skills;Syndrome;targeted agent;Therapeutic;Therapeutic Intervention;therapy development;Thick;Training;transmission process;vision development;Visual;Visual Acuity;Visual impairment;Visual Pathway Astrocytoma;Visual System

PROJECT_TITLE: Defining the Extrinsic and Intrinsic Mechanisms of Vision Loss in Optic Glioma

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Cost Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Rural Health;Telehealth

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The proposed research is relevant to public health because of the high and increasing prevalence of neurodegenerative causes of dementia including Parkinson’s disease dementia, significant barriers to definitive neurologist care in underserved, rural communities, and the potential of remote monitoring to ameliorate these obstacles and improve quality-of-life. Thus, the proposed research is relevant to the NIA’s mission of to reduce the burden of neurodegenerative disease, including dementia, and extend the healthy, active years of life.

PI_NAMEs: SIMMERING, JACOB  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accelerometer;Affect;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;automated analysis;barrier to care;Bradykinesia;burden of illness;career;career development;Caring;Chronic Disease;Clinical;clinical care;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Complex;Computer Vision Systems;cost;Cost Analysis;Data;Data Collection;Dedications;Dementia;Dementia with Lewy Bodies;demographics;Detection;Devices;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Management;Effectiveness;Elderly;Evaluation;Funding;Goals;Grant;Health;health assessment;health economics;Home;human subject;Impaired cognition;Impairment;improved;innovation;Institution;Instruction;instrument;interest;Knowledge;Learning;Life;Measurement;Measures;Medically Underserved Area;mild cognitive impairment;Mission;Modeling;Monitor;Motor;Motor Manifestations;Motor Skills;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nerve Degeneration;Neurobehavioral Manifestations;neurodegenerative dementia;Neurodegenerative Disorders;Neurologist;neuropathology;Neurosciences;Newly Diagnosed;novel;open source;Parkinson Disease;Parkinson's Dementia;Pathology;Performance;Persons;Physical activity;platform-independent;Prevalence;Prognosis;Provider;Public Health;Quality of life;Records;remote monitoring;Research;Research Personnel;Resources;Role;rural area;Rural Community;Signal Transduction;skills;Sleep;Sleep disturbances;Specialist;Speech;success;Symptom Burden;Symptoms;Testing;Time;Tremor;United States National Institutes of Health;Walking;wearable device;wearable sensor technology

PROJECT_TITLE: Remote monitoring using commercially available activity trackers and computer vision provides a holistic, low-cost assessment of Parkinson’s disease symptoms


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Primary Immunodeficiencies;Rare Diseases

PHR: Project Narrative Despite recent advances in therapeutic options showing promising results for patients with pulmonary alveolar proteinosis (PAP), there is still no FDA-approved therapy, and not all patients respond to these therapies. There is a critical need to understand the pathogenic mechanisms that underlie PAP in order to develop novel therapies. This proposal is the first step to unveil these mechanisms by evaluating how disruption in granulocyte- macrophage colony-stimulating factor signaling leads to lipid dysregulation and surfactant accumulation in the alveolar space.

PI_NAMEs: LEE, ELINOR  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Alveolar;Alveolar Macrophages;Automobile Driving;Basic Science;Belief;Biology;Biometry;career;career development;Catabolism;Cholesterol;cholesterol transporters;Clinical Sciences;Critical Care;Data;Defect;Development;Development Plans;Diagnostic;Disease;Environment;Enzymes;Ethics;Evaluation;Fatty Acids;FDA approved;Functional disorder;Future;Genes;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Homeostasis;Human;Immunology;Impairment;improved;in vivo;Inflammation;innovation;Institution;interest;Kinetics;Knowledge;Link;lipid metabolism;Lipids;Lung;Lung Diseases;Macrophage;Manuscripts;Mediating;Medicine;Mentors;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;Nature;novel;novel therapeutics;Outcome;oxidation;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathologic;Patients;pharmacologic;Pharmacotherapy;Phospholipids;Physicians;PPAR gamma;Preparation;Production;programs;Publishing;Pulmonary Alveolar Proteinosis;Pulmonary Surfactants;Research;research and development;Respiratory Failure;Role;Scientist;Signal Pathway;Signal Transduction;skills;surfactant;Testing;Therapeutic;therapeutic development;Therapeutic Research;Training;Training Programs;Translational Research;uptake;vector;Work;Writing

PROJECT_TITLE: Role of GM-CSF and impaired lipid metabolism in the pathogenesis of PAP


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Depression;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Persistent irritability in childhood impacts up to 20 percent of youth and is associated with elevated risk for adolescent mental health problems, such as anxiety and depression, as well as significant functional impairment, including school problems, family problems, and problems with peers. By seeking to understand how prenatal exposure to PAH affects children’s irritability and brain function, this project is a first step towards identifying modifiable environmental risk factors and establishing potential etiologic pathways for persistent irritability. Such knowledge may be used in public health interventions to improve the quality of children’s environment and support the development of novel treatment options for children with irritability.

PI_NAMEs: DESERISY, MARIAH  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 7 year old;Adolescent;adolescent mental health;Affect;Age;air monitoring;Air Pollution;Animal Model;Anxiety;Aromatic Polycyclic Hydrocarbons;Assessment tool;Attention;Behavior;Behavioral;Birth;Brain;brain metabolism;Chemicals;Child;child depression;Child Mental Health;Child Rearing;Childhood;childhood anxiety;cognitive control;cognitive process;cohort;Data;Data Analyses;Depressive disorder;Development;early childhood;Emotional;Emotions;Environment;environmental chemical exposure;Environmental Epidemiology;Environmental Health;Environmental Risk Factor;Epidemiologic Methods;epidemiology study;Ethics;Etiology;Exclusion;experience;Exposure to;Family;Functional impairment;Functional Magnetic Resonance Imaging;Genetic;genetic risk factor;Goals;Health;High-dimensional Modeling;Hispanic;Human;Impaired cognition;improved;Impulsivity;informant;Intervention;K-Series Research Career Programs;Knowledge;Link;Low income;Magnetic Resonance Imaging;Measures;Mediating;Mental Depression;Methods;middle childhood;modifiable risk;multidimensional data;Network-based;neuroimaging;neurotoxic;Neurotoxins;novel;Nursery Schools;Pathway interactions;patient oriented;peer;Phenotype;pollutant;prenatal;prenatal exposure;Preschool Child;prevent;Prevention;programs;Psychopathology;public health intervention;Public Policy;Regulation;Research;Research Personnel;Research Proposals;Resources;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Risk Marker;Sampling;School-Age Population;Schools;Science;skills;social;stem;Symptoms;System;Testing;Time;tool;Training;Vulnerable Populations;Youth

PROJECT_TITLE: Air Pollution Effects on Child Irritability and Brain Connectivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-S (99)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Contraception/Reproduction;Drug Abuse (NIDA only);Estrogen;Neurosciences;Sleep Research;Substance Misuse;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Narrative Using cannabis as a sleep aid may carry specific health harms for women. Cannabis use can affect biological sleep directly or through altering stress-reactivity systems, and such relationships may be influenced by fluctuating reproductive hormones. The goal of this application is to study women across the menstrual cycle and compare sleep, cortisol, and autonomic nervous system functioning on nights of cannabis use versus nights of no use.

PI_NAMEs: BUCKMAN, JENNIFER F.;SPAETH, ANDREA MARIE (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: actigraphy;Acute;addiction;Address;Affect;Antiinflammatory Effect;Autonomic nervous system;Behavioral;Biological;Biological Assay;biological research;Biomedical Technology;Body System;Brain;Cannabis;Cannabis retail;cannabis self-administration;Characteristics;Consumption;cost;Cross-Sectional Studies;Data;Dependence;design;Dissociation;Dose;Electrocardiogram;Electroencephalography;Endocannabinoids;Endocrine;Equilibrium;Estradiol;experience;experimental study;Exposure to;FDA approved;Female;Female of child bearing age;Flowers;Galvanic Skin Response;Goals;Health;heart rate variability;Home;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;improvement on sleep;Individual;Legal;Legal Medicine;lens;Light;marijuana legalization;marijuana use;marijuana user;Marketing;Measures;Mediating;Mediation;Mediator;Menstrual cycle;Nervous System Physiology;neural;neuroprotection;Organ;Outcome;Patient Self-Report;Pattern;Perception;Peripheral;Phase;Physiological;Physiology;poor sleep;Population;Progesterone;proliferative phase Menstrual cycle;Prospective Studies;receptor;Recovery;Recreation;reproductive hormone;Research;Research Design;response;Risk;Role;saliva sample;Salivary;Scientist;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep physiology;sleep quality;Stress;stress reactivity;stress state;Stress Tests;stressor;substance use;System;Testing;theories;Therapeutic;Time;Vaporizer;wearable device;Woman;Women's Health;Women's study

PROJECT_TITLE: The role of stress physiology and reproductive hormones in the relationship between cannabis use and sleep in women of childbearing age