NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Relevance We propose research to enhance the ability of researchers to utilize data from unstructured medical records in their translational cancer research programs. The proposed software platform has the ability to enhance the health of the public by contributing new methods for advancing cancer research.

PI_NAMEs: HOCHHEISER, HARRY S;SAVOVA, GUERGANA K. (contact);WARNER, JEREMY LYLE

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Academic Medical Centers;Address;Adjuvant;Advanced Malignant Neoplasm;Adverse event;analytical tool;anti-cancer research;Area;autism spectrum disorder;Bioinformatics;Brain Aneurysms;cancer care;cancer initiation;Cancer Patient;Cancer Research Project;cancer subtypes;cancer type;Caring;Case Study;Characteristics;chemotherapeutic agent;chemotherapy;Clinic;Clinical;clinical care;Clinical Informatics;clinical investigation;cohort;Collaborations;Colorectal Cancer;Communities;Community Clinical Oncology Program;Community of Practice;comorbidity;Complement;Computer software;Computerized Medical Record;Computing Methodologies;Consumption;Dana-Farber Cancer Institute;Data;Data Science;data streams;Decision Making;design;Diagnosis;Diagnostic;Disease;Epigenetic Process;Evaluation;follow-up;Funding;Gene Amplification;Genetic;Genomics;Growth;Hematologic Neoplasms;Hepatotoxicity;Immune System Diseases;individual patient;Informatics;informatics tool;information organization;Information Retrieval;innovation;insight;interactive tool;interest;Investigation;Laboratory Finding;large cell Diffuse non-Hodgkin's lymphoma;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuals;Measures;Medical;Medical Records;Melanoma;Methods;Methotrexate;Modeling;Morphology;Multiple Sclerosis;Natural Language Processing;Neoadjuvant Therapy;Neoplasm Metastasis;next generation sequencing;novel;Oncology;open source;Pathology;Patient-Focused Outcomes;Patients;Phenotype;Postoperative Period;precision medicine;Process;programs;Public Health;Rare Diseases;Recording of previous events;Records;Research;Research Personnel;response;Rheumatoid Arthritis;Severities;Solid;Source;Stress;System;Techniques;Technology;Testing;Text;Time;timeline;tool;translational cancer research;Translational Research;translational scientist;Treatment Protocols;treatment response;tumor;tumor behavior;unstructured data;usability;Visual;Visualization;Work

PROJECT_TITLE: Cancer Deep Phenotype Extraction from Electronic Medical Records


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Bacteria have major impacts on human wellness, both as the causes of acute infections and as members of the health-promoting microbiome. The research described in this proposal is aimed at understanding how bacteria sense and respond to antimicrobial oxidants produced by innate immune cells at the interface between microbes and host organisms. We expect the results of these studies to contribute to fundamental knowledge about how both health- and disease-associated bacteria interact with the immune system, which, in the long term, will facilitate the development of new strategies to manipulate those interactions to promote human health.

PI_NAMEs: GRAY, MICHAEL JEFFREY (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: biological adaptation to stress;host-microbe interactions;Molecular

PROJECT_TITLE: Molecular Mechanisms of Bacterial Stress Response Relevant to Host-Microbe Interactions

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Bacterial virulence is closely associated with nutrient acquisition, which is essential for growth and proliferation of pathogens; metal ions constitute essential nutrients, and thus the regulation of bacterial metal ion homeostasis within the host environment plays a pivotal role for survival. Non-essential xenometal ions with identical charge, comparable ionic radius and chemical hardness to essential metal ions can take advantage of and critically disrupt essential metal homeostasis in bacteria by to-date unknown mechanisms. Here, we seek to uncover how the high spin Fe3+ mimics Ga3+, Sc3+, and In3+ are transported to the bacterial cytoplasm and interact with the bacterial proteo- and metabolome.

PI_NAMEs: BOROS, ESZTER  (contact)

PROJECT_TITLE: Tracking, elucidation and modulation of xenometal homeostasis in bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Microbiome;Nutrition;Obesity

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Consumption of non-nutritive sweeteners (NNS) is a popular dietary approach, yet epidemiological evidence suggest that NNS promote, rather than prevent, obesity and hyperglycemia. In my graduate work I demonstrated that NNS promote weight gain and glucose intolerance by disrupting the microbiome, yet the underlying mechanisms remain unclear. This work will seek to identify the mechanisms through which NNS shape the microbiome, and the NNS-perturbed microbiome affects host metabolic health.

PI_NAMEs: SUEZ, JOTHAM  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adipose tissue;Affect;Animals;Aspartame;Bacteria;bacterial metabolism;Benefits and Risks;Big Data;Bioinformatics;Biological Models;Bioremediations;Calories;Cardiovascular Diseases;cellular targeting;Clinical Trials;Communities;Consumption;cost;Coupled;Data;Data Set;Development;Diabetes Mellitus;Diet;dietary approach;Education;Endotoxemia;Energy Intake;Engineering;Environment;Epidemiology;Etiology;evidence base;experience;exposed human population;Exposure to;Faculty;Financial Support;follow-up;Gene Expression;Genetic Complementation Test;Germ-Free;global health;Glucose;Glucose Intolerance;glucose tolerance;gut microbiome;gut-brain axis;Health;Health Benefit;host microbiome;Human;Hyperglycemia;improved;in vivo;Individual;Institution;Intestines;Knock-out;Label;large datasets;Link;Lipids;Lipopolysaccharides;Literature;Liver;Mass Spectrum Analysis;Mediating;Mediator;Mentors;Metabolic;metabolic endotoxemia;metabolic profile;Metabolic syndrome;Metabolism;metabolomics;microbial community;microbiome;microbiome analysis;microbiome composition;microbiome research;Mucous body substance;Mus;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Overweight;pandemic disease;Pathogenesis;Pathway interactions;Persons;phenomics;Policies;Polysaccharides;Positioning Attribute;Predisposition;Prevalence;prevent;Production;Publishing;Reaction;receptor;Reporting;Research;response;Role;Saccharin;sequencing platform;Shapes;Signal Transduction;sugar;sweet taste perception;Sweetening Agents;Technology;Testing;Tissues;TLR4 gene;Toxic effect;transcriptome;Vagotomy;Volatile Fatty Acids;Weight Gain;weight gain prevention;Work

PROJECT_TITLE: The role of non-nutritive sweeteners-microbiome interactions in the pathogenesis of metabolic syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Findings from the proposed line of research will link accelerated brain and biological aging in midlife to brain aging in older adults with cognitive impairment as well as Alzheimer’s disease and related dementias (ADRD). These findings may help uncover the origins and risk factors for individual differences in brain aging that could help identify those most in need of intervention in midlife as well as help develop novel preventions to target ADRD before disease onset. The long-term goal of this line of research is to lower the global burden of ADRD by advancing our understanding of individual differences in brain aging.

PI_NAMEs: ELLIOTT, MAXWELL LORENZ (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;Age;age acceleration;age related decline;age-related disease;Aging;aging biomarker;aging brain;aging population;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;archived data;Area;Award;Behavioral;biobank;Biological;Biological Aging;Biological Markers;Birth;Brain;Caring;Child;Childhood;Cognitive;Cognitive aging;cohort;Complement;Data;dementia risk;Deterioration;Disabling;Disease Progression;Early Intervention;Effectiveness of Interventions;effectiveness testing;Ensure;Etiology;evidence base;Exposure to;Functional impairment;Gasoline;Geroscience;Goals;Health;healthy aging;Impaired cognition;in vivo;indexing;Individual;Individual Differences;insight;Intervention;late life;Lead;lead exposure;Life;life span;Link;Magnetic Resonance Imaging;Maps;Measures;member;middle age;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroimaging;Neurosciences;Neurosciences Research;Neurotoxins;New Zealand;novel;older adult;Onset of illness;Organ;Pathology;Phase;Phenotype;Population;Postdoctoral Fellow;prevent;Prevention;Prevention Research;Proliferating;rate of aging;Research;Research Project Grants;Risk;Risk Factors;Sampling;social;Statistical Methods;Surface;Surrogate Markers;tau Proteins;Techniques;Testing;theories;Thinness;Training;White Matter Hyperintensity;Work;years of life lost to disability

PROJECT_TITLE: Training in lifespan behavioral, social, and neuroscience research connecting early-life cognitive decline to late-life ADRD


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal of this proposal is to define the molecular mechanisms of structural plasticity (or polydispersity) that enable the lens a-crystallins to provide their critical function of maintaining life-long proteostasis and transparency of the eye lens. I will apply cutting-edge technologies centered around the use of CryoEM and CryoET to directly visualize the polydisperse state(s) of apo-state a-crystallin and decipher its mechanism of chaperone function. Ultimately, these studies will lay critical ground work required for developing a molecular understanding of how the a-crystallins contribute to the lens health and age-related cataract formation.

PI_NAMEs: MILLER, ADAM PHILLIP (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: age related;aggregation pathway;Alzheimer's Disease;Binding;biophysical techniques;Biophysics;Blindness;C-terminal;Cataract;Chemicals;Client;Complex;Coupled;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Crystalline Lens;Crystallins;Crystallization;cytotoxic;Development;Disease;Disease Progression;Environment;Event;Evolution;experimental study;flexibility;Functional disorder;Goals;Health;Heat shock proteins;Heterogeneity;insight;Knowledge;Length;lens;Lens Diseases;lens transparency;light scattering;member;Methods;Modeling;Modification;Molecular;Molecular Chaperones;Muramidase;N-terminal;Nature;non-Native;novel strategies;Parkinson Disease;particle;Pathway interactions;Play;Population;prevent;protein aggregation;Protein Family;protein folding;Protein Isoforms;Proteins;proteostasis;rational design;Research;Resolution;response;Role;Solubility;structural biology;structural determinants;Structure;success;System;Technology;Therapeutic;Time;Vision;Visualization;Work;α-Crystallins

PROJECT_TITLE: Mechanisms of structural plasticity, client interactions, and co-aggregation of the lens ⍺-crystallins


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The claustrum is a central, connectional hub in the brain, and yet its functions have eluded characterization due to its narrow geometry and subcortical location. Claustral circuits are thought to influence visuomotor behavior and cognition, and disruption of those circuits may contribute to a wide range of neurological and neuropsychiatric disorders. This project examines the visuomotor roles of a specific claustral circuit using new approaches for identifying, studying, and manipulating neurons in the primate brain, with the overall goal of understanding claustral function in health and disease.

PI_NAMEs: EL-NAHAL, HALA GALAL (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;anatomical tracing;Animal Model;Animals;Appearance;Area;Attention;Back;Behavior;Behavioral;Brain;Brain Diseases;career;Cells;Cerebral cortex;Claustral structure;clinically relevant;Cognition;cognitive function;decrease resilience;Disease;distraction;Esthesia;Esthetics;Exhibits;experimental study;extracellular;Eye Movements;fluorophore;frontal eye fields;Functional Magnetic Resonance Imaging;Genes;genetic approach;Genetic Techniques;genetic technology;Geometry;Goals;gray matter;Health;Histology;Human;Injections;Jaw;Label;Location;Macaca;Maps;Mediating;Methods;Monkeys;Motor;Movement;Nervous System Disorder;neural;Neurons;neurophysiology;neuropsychiatric disorder;nonhuman primate;novel strategies;Operative Surgical Procedures;Opsin;Optics;optogenetics;Outcome;Pain;Pathologic;Performance;Physiological;Prefrontal Cortex;Primates;Proteins;Psychophysics;Publishing;Rattus;Recombinant adeno-associated virus (rAAV);Research Design;Rodent;Role;Saccades;Sensorimotor functions;Shapes;Signal Transduction;Sleep;Specificity;Stimulus;Structure;System;Techniques;Technology;Testing;Thinness;Training;Translating;Viral;Viral Vector;Virus;virus testing;Vision;Visual;visual cognition;visual motor;Work

PROJECT_TITLE: Circuit-Specific Interrogation of the Primate Claustrum


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_DEPT: SURGERY

PHR: A recently approved therapy for triple-negative breast cancer (TNBC) targets the PD1/PDL1 immune checkpoint pathway to reinvigorate an anti-tumor immune response, however the majority of patients do not respond. Gaining insights into the unknown barriers to an effective anti-tumor immune response is a critical unmet need that will benefit from new mouse models that more closely recapitulate the patient’s tumor microenvironment and more sophisticated genomic tools and analysis. This proposal seeks to understand which patients will benefit and how to increase the number of responders across all molecular subtypes of breast cancer using intratumoral immunotherapy that augments T cell infiltration directly.

PI_NAMEs: CROSBY, ERIKA J (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: adaptive immune response;Address;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antitumor Response;Biological Markers;BRCA1 gene;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer infiltrating T cells;cancer type;CD8-Positive T-Lymphocytes;Cells;chemokine;Clinical;Clinical Data;Clinical Research;Combination immunotherapy;CRISPR screen;CXCL9 gene;CXCR3 gene;Data;Data Set;design;Disease;disorder control;Electroporation;Electroporation Therapy;engineered T cells;Engineering;ERBB2 gene;follow-up;Funding;Gene Targeting;Generations;Genes;genetic signature;genomic tools;Goals;Grant;Half-Life;Immune;immune activation;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunologics;Immunotherapy;improved;improved outcome;Individual;individualized medicine;Infiltration;Injections;insight;Interleukin-12;K22 Award;knock-down;Lesion;Licensing;Ligands;Malignant Breast Neoplasm;Mammary Neoplasms;migration;Modeling;Molecular;molecular subtypes;Monitor;mouse model;Oncogenes;Oncogenic;Outcome;Paclitaxel;Pathway interactions;Patients;PD-1/PD-L1;phase 2 study;Plasmids;pre-clinical;Productivity;prognostic;programs;Progression-Free Survivals;Proteins;PTEN gene;Publishing;receptor;Recombinant Interleukin-12;Recurrence;Research;Research Design;Resources;response;Role;Signal Transduction;single-cell RNA sequencing;Site;survival outcome;systemic toxicity;T cell infiltration;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Time;Toxic effect;TP53 gene;trafficking;transcriptome sequencing;Translating;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Intratumoral immunotherapy to enhance T cell infiltration and augment immune checkpoint blockade responses across molecular subtypes of breast cancer


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Nanotechnology;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE: Although impressive methods and imaging techniques exist to characterize the functional networks of the human brain, clinical application of functional neuroimaging is impeded by its low sensitivity. The proposed research aims to develop and validate a novel functional neuroimaging modality, known as magnetic particle imaging (MPI) for mapping the brain’s functional networks. If the sensitivity of the new method is sufficiently improved compared to other methods, the proposed research will advance our ability to characterize functional connectivity mappings in individual patients and apply knowledge of brain network changes to the diagnosis and management of mental illnesses.

PI_NAMEs: DRAGO, JOHN MICHAEL (contact)

PROJECT_TERMS: Alzheimer's Disease;Amplifiers;analog;Anatomy;Biomedical Engineering;Blood;blood oxygen level dependent;Brain;Brain imaging;BRAIN initiative;Brain Mapping;cerebral blood volume;Clinical;clinical application;Clinical Treatment;Cognition;Data;design;Detection;detection sensitivity;Development;Devices;Diagnosis;disease phenotype;Dose;Economics;Exhibits;experimental study;ferumoxytol;Functional Magnetic Resonance Imaging;Goals;Head;hemodynamics;Human;Image;image reconstruction;Imaging Device;imaging modality;Imaging Phantoms;imaging system;Imaging Techniques;improved;Individual;individual patient;Injections;iron deficiency;iron oxide nanoparticle;Knowledge;Macaca;Macaca mulatta;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modality;Modeling;Nervous System Disorder;neural;neuroimaging;Neurons;neuropsychiatric disorder;Noise;novel;novel strategies;Nuclear Magnetic Resonance;particle;Phenotype;Physiological;Protons;prototype;Research;Research Personnel;Resolution;response;Rest;Rodent;Rodent Model;Role;Running;Safety;Schizophrenia;Series;Signal Transduction;Stimulus;superparamagnetism;Testing;theories;Time;tomography;tool;Tracer;Translating;transmission process;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Resting-state functional connectivity mapping using Magnetic Particle Imaging (MPI)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative In this Program, we address shortcomings in our understanding of the pathogenesis of human cGVHD and our ability to prioritize the next generation of therapeutic strategies by defining the immune networks that characterize patients who develop cGVHD and interrogate the mechanisms of both success and failure of cGVHD treatment regimens. We explore the unique metabolic demands in cGVHD pathogenesis and lung injury repair and focus therapeutics on the most severe manifestation of cGVHD, BOS. We employ novel organoid cultures and immunogenomics to pinpoint the cellular and antigenic targets of BOS.

PI_NAMEs: CUTLER, COREY S (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: 3-Dimensional;Acute Graft Versus Host Disease;Address;Affect;Alloantigen;Allogenic;Alveolar;Antigens;B-Lymphocytes;Bioenergetics;Biological Assay;Biological Markers;Biometry;Blood;Bronchiolitis Obliterans;Cell Communication;cell type;Cells;cellular targeting;Chronic;chronic graft versus host disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;conditional knockout;Coupled;data management;Defect;diagnostic signature;Disease;Dose;drug testing;effector T cell;Energy-Generating Resources;Engineering;Epithelium;Epitopes;Equilibrium;Evolution;experimental study;Exposure to;Failure;Fibrosis;Gene Expression;Gene Modified;Guide RNA;Helper-Inducer T-Lymphocyte;Hematopoietic Stem Cell Transplantation;Human;Image;Immune;Immune Targeting;Immune Tolerance;Immunogenetics;Immunogenomics;Immunologic Monitoring;Immunologics;in vitro regeneration;in vivo evaluation;Individual;Inflammation;inflammatory milieu;inhibitor;injury and repair;Interleukin-2;Link;Lung;Lung Diseases;lung injury;lung regeneration;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;novel;novel therapeutics;Organ;Organoids;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;phase II trial;Population;Prediction of Response to Therapy;Principal Investigator;Process;profiles in patients;programs;Proliferating;Regulatory T-Lymphocyte;Resistance;Resolution;responders and non-responders;response;Rest;Risk;RNA library;single cell analysis;single-cell RNA sequencing;Site;Specificity;stem cell function;Structure of germinal center of lymph node;success;Syndrome;T cell infiltration;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;Tissue Banks;Tissues;transcriptome;transplant survivor;Transplantation;Treatment Protocols;treatment response;treatment strategy;Writing

PROJECT_TITLE: Mechanisms and Therapy of Chronic Graft-vs.-Host Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Vaccine Related

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Public Health Relevance Statement We will evaluate a combination targeted therapy to enhance the effectiveness of tumor specific peptide vaccine (PEPIDH1M) for mutant IDH1 glioma by reducing tumor-expressed levels of the immunosuppressive oncometabolite 2-hydroxyglutarate (2HG) using vorasidenib. Non-invasive magnetic resonance spectroscopic imaging maps of 2HG levels will permit longitudinal monitoring of vorasidenib efficacy. This study will demonstrate the feasibility of patient tolerance to this combined therapy and establish a simple tool for longitudinal assessment of 2HG changes due to vorasidenib, or other mIDH1/2 inhibitors, for future trials.

PI_NAMEs: PETERS, KATHERINE B;SOHER, BRIAN J (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adult;Automation;Automobile Driving;Blood;Brain;Brain Neoplasms;Cancer Therapy Evaluation Program;cell killing;cell mediated immune response;Clinical;clinical decision-making;clinical research site;Clinical Trials;combinatorial;Combined Modality Therapy;Common Terminology Criteria for Adverse Events;computerized data processing;design;Development;diagnostic biomarker;diagnostic technologies;Digital Imaging and Communications in Medicine;early phase clinical trial;Effectiveness;Enzymes;Evaluation;Event;experience;fighting;first-in-human;Future;Genes;Glioma;Gliomagenesis;Goals;human study;Image;image guided intervention;Immune;immunogenic;Immunologics;Immunosuppression;Immunotherapeutic agent;Impairment;improved;Infrastructure;inhibitor;inhibitor therapy;Isocitrate Dehydrogenase;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Manufacturer;Maps;Measurement;Measures;Mediating;Methods;Mission;Monitor;Morbidity - disease rate;mortality;mutant;Mutation;neoplastic cell;Neurologic;new therapeutic target;non-invasive monitor;novel;novel anticancer drug;novel diagnostics;novel therapeutics;Oncogenic;Outcome;patient tolerability;Patients;Peptide Vaccines;Phase;phase I trial;Production;Progression-Free Survivals;Proteins;Protocols documentation;public health relevance;Quality of life;radiological imaging;Recurrence;Reporting;Research;research clinical testing;response;Role;Safety;safety assessment;Serum;Serum Markers;Signal Transduction;Speed;standard of care;Standardization;support tools;synergism;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;tool;Toxic effect;Translating;Translations;treatment strategy;tumor;tumor diagnosis;Tumor Specific Peptide;tumorigenesis;vaccine development;Vaccine Therapy;Vaccines;Validation;Work

PROJECT_TITLE: Clinical evaluation and non-invasive monitoring of Vorasidenib in combination with tumor specific peptide PEP-IDH1M vaccine therapy in patients with recurrent mutant IDH1 glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


PROJECT_TERMS: Basic Science;Biometry;Boston;Cell Therapy;Childhood;Chronic;Clinical Trials;Dana-Farber Cancer Institute;Disease;Goals;human subject;In Vitro;in vivo;Individual;Institution;meetings;Minnesota;Monitor;Participant;Pediatric Hospitals;Pre-Clinical Model;Program Research Project Grants;programs;Progress Reports;Regulation;Reporting;Research;Research Personnel;success;synergism;Transplantation;transplantation therapy;Universities;Vertebrates

PROJECT_TITLE: Admin Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Immunotherapy;Lung;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: LIVAK, KENNETH JAMES (contact)

PROJECT_TERMS: Address;Algorithms;alpha-beta T-Cell Receptor;Antigens;Applications Grants;beta Chain Antigen T Cell Receptor;Binding;Bronchiolitis Obliterans;Cell Line;Cell Physiology;Cells;Characteristics;Chronic;chronic graft versus host disease;Clinical;Cloning;computerized tools;Data;Data Analyses;Databases;Disease;disease model;DNA;DNA analysis;DNA sequencing;exome sequencing;Genetic Transcription;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Immune;Immune response;Immunogenetics;immunogenicity;Immunogenomics;Immunologics;Individual;insight;Laboratories;Lung;Metabolic;Minor Histocompatibility Antigens;mouse model;Mus;new technology;Outcome;Pathogenesis;Pathway interactions;Patients;Peptides;Population;Principal Investigator;Resistance;response;Sampling;single cell analysis;single cell sequencing;Single Nucleotide Polymorphism;Specimen;Syndrome;T cell clonality;T cell response;T-Cell Immunologic Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;TCR Activation;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;treatment response;tumor-immune system interactions;Variant;Writing

PROJECT_TITLE: Single Cell Analysis and Immunogenetics


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: RITZ, JEROME  (contact)

PROJECT_TERMS: Adult;Allogenic;antibody conjugate;Antigen Targeting;biobank;Biological Assay;Bone Marrow;Boston;Bronchoalveolar Lavage;Cells;Characteristics;Chronic;chronic graft versus host disease;Clinical;Clinical Trials;Collection;computerized;Correlative Study;Cryopreservation;cytokine;Cytomegalovirus;Cytometry;Dana-Farber Cancer Institute;Data;Disease;DNA;donor stem cell;Dose;Enrollment;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Equipment and supply inventories;Equity;experimental study;Flow Cytometry;Fluorochrome;Hematopoietic Stem Cell Transplantation;Hospitals;Human Herpesvirus 4;immune function;immune reconstitution;Immunity;Immunologic Monitoring;immunological intervention;improved;Individual;Informed Consent;Institutional Review Boards;Interleukin-2;Intervention;Kinetics;Laboratories;Lymphocyte;Measures;Metals;Monitor;Monoclonal Antibodies;Mononuclear;novel therapeutics;Outcome;participant enrollment;patient privacy;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;peripheral blood;Peripheral Blood Mononuclear Cell;Peripheral Stem Cell Transplantation;Phenotype;Plasma;Play;Policies;Population;prevent;Principal Investigator;Process;programs;prospective;Protocols documentation;Research Personnel;research study;Resources;RNA;Role;sample collection;Sampling;Serum;Stem cell transplant;T cell reconstitution;Therapeutic Agents;Tissue Banks;transplant database;Transplantation;Woman;Writing

PROJECT_TITLE: Biobanking and Immunologic Monitoring


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Complementary and Integrative Health;Health Effects of Indoor Air Pollution;Hyperbaric Oxygen

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project narrative: Carbon monoxide poisoning results in an estimated 50,000 emergency department visits in the United States annually and is one of the leading causes of poisoning death. In the current proposal we aim to develop a specific antidotal therapy that can be given in the field by paramedics that can remove carbon monoxide from red blood cells, tissues, and heart and brain mitochondria within minutes. The availability of an effective antidote for carbon monoxide has the potential to dramatically change the current treatment and substantially decrease death and disability caused from this common poisoning.

PI_NAMEs: GLADWIN, MARK T (contact);TEJERO BRAVO, JESUS

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Affinity;Amino Acids;Antidotes;Apoptosis;Binding;Binding Sites;Biochemical;Blood;Blood Pressure;Blood Substitutes;Brain;Brain Edema;Brain Injuries;Carbon Monoxide;Carbon Monoxide Poisoning;Carboxyhemoglobin;Cardiovascular Physiology;Cardiovascular system;Carrying Capacities;Cause of Death;Cell Respiration;Cessation of life;chemical stability;Chemicals;Circulation;Clinical;clinical development;Cognitive;cognitive function;cytochrome c oxidase;design;Development;Diffusion;disability;Distal;Dose;efficacy evaluation;efficacy testing;Electron Transport;Emergency department visit;Endotoxins;Engineering;Environment;Erythrocytes;Escherichia coli;Excision;exhaust;Exhibits;Exposure to;Fire - disasters;Funding;Generations;Glutamine;Half-Life;Heart;Heart Rate;Heme;heme a;Heme Iron;Hemeproteins;Hemoglobin;Histidine;Home;Human;Human Engineering;human induced pluripotent stem cells;Hydrogen Peroxide;Hyperbaric Oxygen;Hyperbaric Oxygenation;Hyperbaric Therapy;Image;improved;In Vitro;in vitro testing;in vivo;Infusion procedures;Inhalation;innovation;Intravenous;Intravenous infusion procedures;Ischemia;Kidney;Knowledge;Lead;Ligands;Long-Term Effects;Magnetic Resonance Imaging;Methods;Mission;Mitochondria;Modeling;Modification;Molecular;mouse model;Mus;Mutate;Mutation;National Heart, Lung, and Blood Institute;Necrosis;nephrotoxicity;Neurocognitive Deficit;neuroglobin;next generation;Nitrite Reductase;Nitrogen;novel;Organ;organ injury;Organoids;Oxidation-Reduction;Oxygen;Paramedical Personnel;Pathologic;Patients;Persons;point of care;Poison;Poisoning;pre-clinical;Pre-Clinical Model;Precipitation;prevent;Production;programs;Property;Protein Engineering;Proteins;Public Health;Reaction;Recombinant Proteins;Recombinants;Regulation;Research;Respiration;restoration;Risk;Safety;sensor;Site;Solubility;Sulfhydryl Compounds;Surface;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;Tubular formation;United States;United States National Institutes of Health;Urea;water maze;Work;Yeasts

PROJECT_TITLE: Antidote for inhaled CO poisoning based on mutationally engineered neuroglobin

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: KIM, HAESOOK T (contact)

PROJECT_TERMS: Acute Graft Versus Host Disease;Allogenic;Animals;B-Lymphocytes;Biometry;Blinded;Blood;Bronchiolitis Obliterans;cellular targeting;Chronic;chronic graft versus host disease;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;Collaborations;Collection;Complex;computerized data processing;computing resources;Data;Data Analyses;Data Element;data management;Databases;Dedications;Disease;disorder prevention;Epitopes;Fibrosis;Functional disorder;Goals;graft vs host disease;graft vs leukemia effect;Hematopoietic Stem Cell Transplantation;Immune;Immune system;Immune Targeting;Immunologics;Impairment;inhibitor;Laboratories;laboratory experiment;Laboratory Research;Laboratory Study;Lung;lung injury;Maintenance;Malignant Neoplasms;Manuscripts;Mediating;Morbidity - disease rate;mortality;novel therapeutics;operation;Organoids;Outcome;Pathway interactions;Patients;Phase II Clinical Trials;Policies;Principal Investigator;Procedures;programs;Protocols documentation;Pulmonary Fibrosis;Quality Control;Quality of life;Recurrent disease;Reporting;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;response;Services;Standardization;Statistical Data Interpretation;Syndrome;T-Lymphocyte;Therapeutic;Therapeutic Agents;therapeutic target;Translational Research;translational study;Writing

PROJECT_TITLE: Biostatistics and Data Management


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative This project aims to establish a multiplexed imaging and synthetic biology platform to mechanistically understand chromatin regulation and its functional role in the peripheral olfactory system. Specifically, Aim 1 is to develop a high-throughput, multi-modal imaging method to directly visualize the 3D organization of DNA together with key regulatory proteins and the transcriptional output controlling the fates of single-neurons in the olfactory epithelium. Aim 2, is to deliver and image large libraries of compact viruses containing different combinations of regulatory elements and gene promoters to enable specific transgenic control of the different sub-populations of olfactory neuronal types.

PI_NAMEs: BINTU, BOGDAN  (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;Animal Behavior;Atlases;Behavior;Biology;California;Catalogs;Cell Physiology;cell type;Cells;Chromatin;Chromatin Structure;Collaborations;Communities;Complex;Computational Biology;design;Development;Developmental Biology;Discipline;DNA;DNA biosynthesis;DNA Repair;DNA Sequence;DNA Structure;Elements;Ensure;epigenomics;Event;experience;expression vector;Funding;gene delivery system;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Family;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Genomic approach;genomic locus;Genomic Segment;Genomics;Image;imaging modality;imaging platform;Individual;Institution;Libraries;Maps;Measurement;Measures;Medicine;Methods;Microscopy;Modeling;Molecular Biology;Multimodal Imaging;multiplexed imaging;Nervous System;Neurons;Neurosciences;Nucleic Acid Regulatory Sequences;Olfactory Epithelium;Olfactory Pathways;olfactory receptor;Olfactory Receptor Neurons;olfactory sensory neurons;Organism;Output;Peripheral;Process;professor;promoter;protein structure;Proteins;receptor;receptor expression;Receptor Gene;Regulation;Regulator Genes;Regulatory Element;Research;Resolution;Resources;RNA;Role;Scientist;Series;Smell Perception;Structural Protein;supportive environment;synergism;synthetic biology;System;Technology;tenure track;Testing;three dimensional structure;three-dimensional visualization;Tissues;tool;transgene delivery;Transgenic Organisms;Universities;vector;Viral Vector;Virus;Vision;Work

PROJECT_TITLE: High-throughput imaging of 3D chromatin regulation events in the nervous system


NIH_SPENDING_CATS: Rare Diseases;Transplantation

PI_NAMEs: KEAN, LESLIE S (contact)

PROJECT_TERMS: adjudication;Adoptive Cell Transfers;AREG gene;Automobile Driving;biobank;Biological Markers;Blood;Candidate Disease Gene;CD28 gene;CD80 gene;Cell Therapy;Cells;Cellular biology;chemokine;Chronic;chronic graft versus host disease;Classification;Clinical;Clinical Data;clinical development;Collaborations;cytokine;Data;design;Development;diagnostic signature;dimensional analysis;Disease;disease diagnosis;Dose;Engineering;Epitopes;Evolution;experience;Failure;Flow Cytometry;Functional disorder;Gene Modified;Generations;Genes;Goals;Hematopoietic Stem Cell Transplantation;Human;Immune;Immunologics;In complete remission;individual patient;inhibitor;insight;Interleukin-2;interleukin-21;Libraries;Link;Lung;Mediator;Modality;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;next generation;novel therapeutics;Outcome;partial response;Pathogenesis;Pathway interactions;Patients;Phosphotransferases;Population;Positioning Attribute;Prevention strategy;profiles in patients;Prophylactic treatment;quality assurance;Refractory;Regulatory T-Lymphocyte;repository;Resistance;responders and non-responders;response;rho;Risk;ROCK1 gene;Sampling;Signal Transduction;Steroids;success;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Transplant Recipients;Treatment Protocols;treatment response;treatment strategy;Validation;Work

PROJECT_TITLE: Defining the T Cell Mediators of Clinical Response in Chronic GVHD


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE  This renewal proposal aims to advance precision nanomedicine by combining achievements in single-particle investigations of nanoparticle-cell interactions and mechanistic insight into biological responses. Resolving these fundamental interactions at the relevant time and length scales for ligand-receptor recognition and internalization will deepen understanding of endocytosis and immunomodulatory responses, key processes for improvements in drug delivery and vaccine design.

PI_NAMEs: ODOM, TERI WANG (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Continuous Probing of Nanoconstruct-Cell Interactions at Biologically Relevant Time Scales

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Biotechnology;Genetics;Lung;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: BLAZAR, BRUCE R (contact)

PROJECT_TERMS: 3-Dimensional;Acetyl-CoA Carboxylase;Affect;airway epithelium;allotransplant;Alveolar;B-Lymphocytes;Benchmarking;Biological Assay;Body System;Bronchiolitis Obliterans;Candidate Disease Gene;candidate identification;Cell Proliferation;cell regeneration;cell type;Cells;Chronic;chronic graft versus host disease;Chronic stress;Clinic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Complex;conditional knockout;Data;Defect;Deposition;Disease;Distal;drug candidate;drug metabolism;Drug Targeting;Energy-Generating Resources;Enzymes;epithelial stem cell;Epithelium;exhaustion;fatty acid oxidation;Fatty Acids;FDA approved;Fibrosis;Functional disorder;Gene Deletion;gene discovery;Gene Targeting;Genes;Gluconeogenesis;Glucose;Glucose Transporter;Glutaminase;Glutamine;glutamine analog;Glycolysis;Goals;Guide RNA;Helper-Inducer T-Lymphocyte;Human;Hypoxia;Immune;Immune response;Immune System Diseases;Immunoglobulin Class Switching;Immunoglobulins;improved;In Situ;in vivo;in vivo evaluation;inhibitor;Injury;injury and repair;insight;Knock-out;Knockout Mice;Label;Libraries;Ligands;lipid biosynthesis;Lung;lung injury;lung regeneration;lung repair;Maintenance;Mesenchymal;Mesenchyme;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metformin;Modeling;Morbidity - disease rate;mortality;Mus;Natural regeneration;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Norleucine;novel strategies;novel therapeutics;Nutrient;Nutrient Depletion;Organoids;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;Palmitates;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;phase III trial;Predictive Value;preservation;prevent;progenitor;Proliferating;Pseudostratified Epithelium;pulmonary function;Reactive Oxygen Species;receptor;repaired;Resistance;restraint;RNA library;RNA metabolism;Sampling;single-cell RNA sequencing;SLC2A1 gene;stem;stem cell proliferation;stem cell self renewal;stem cells;Steroids;Structure of germinal center of lymph node;Supporting Cell;T-Lymphocyte;Testing;Therapeutic Index;therapy outcome;Time;Tissues;Trachea;transcriptome sequencing;Transgenic Organisms

PROJECT_TITLE: Metabolomics of cGVHD


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Several studies have demonstrated the ability of animals to detect disease states by olfaction alone, yet the mechanisms of odor-based disease diagnostics are unknown. We will use the olfactory system of the mouse to explore the representation of disease states in the olfactory bulb. Understanding how animals sense disease has the potential to revolutionize public health through the development of rapid, noninvasive screening technologies.

PI_NAMEs: RINBERG, DMITRY  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Afferent Neurons;Algorithms;Alzheimer's Disease;analytical method;Animals;Area;awake;Axon;Behavioral;Biological;Biological Assay;Blood;Brain;Calcium;Canis familiaris;Chemicals;Chronic;clinical diagnostics;Code;Cognitive;combinatorial;Communication;Complex;computational pipelines;Computing Methodologies;COVID-19;Data Collection;Detection;detection method;detection platform;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic assay;diagnostic strategy;dimension reduction;Disease;disease diagnostic;disease model;Environment;Ethology;experimental study;Food;Future;Gas Chromatography;human disease;Image;imaging modality;Implant;Implanted Electrodes;improved;In Vitro;in vivo;Infection;innovation;insight;Intercept;interest;Malaria;Malignant neoplasm of lung;Malignant Neoplasms;Mass Fragmentography;Mass Spectrum Analysis;Metabolic;Metabolic Diseases;Methods;miniaturize;Modernization;Monitor;mouse model;Mus;neural;neuromechanism;Neuropil;Neurosciences;Noise;noninvasive diagnosis;Nose;novel;Odors;olfactory bulb;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Optics;pandemic disease;Parkinson Disease;Partner in relationship;Pattern;Pattern Recognition;peer;Physiology;Population;Preparation;preservation;Process;Public Health;public health emergency;rapid diagnosis;Rattus;receptor;remote diagnosis;Research;Resolution;response;Sampling;scale up;screening;sensor;Signal Transduction;Smell Perception;spatiotemporal;Stimulus;Techniques;Technology;Training;training data;Translating;Tuberculosis;Urine;Vision;volatile organic compound;Volatilization

PROJECT_TITLE: Odorprint Based Disease Diagnostics


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PROJECT_TERMS: Actins;Address;Affect;Aftercare;Air;Air Movements;airway epithelium;Allogenic;Antigen Targeting;antigen-specific T cells;Antigens;Biological Markers;Bronchioles;Bronchiolitis Obliterans;Bronchoalveolar Lavage;CD4 Positive T Lymphocytes;Cell Communication;cell injury;Cells;cellular targeting;Chronic;Clinical Trials;Coculture Techniques;cohort;Data;Disease;Enrollment;Epithelial Cells;epithelial stem cell;Epithelium;Epitopes;Fibroblasts;Fibrosis;Functional disorder;Generations;Genetic Transcription;Helper-Inducer T-Lymphocyte;Hematopoietic Stem Cell Transplantation;Human;idiopathic pulmonary fibrosis;Image;imaging biomarker;imaging modality;Immune;Immune Targeting;Immune Tolerance;Immunity;Immunogenomics;Immunologics;Immunosuppressive Agents;improved;in vitro Model;Infiltration;inhibitor;innovation;Link;Lung;Lung Diseases;Lung Transplantation;Maps;Measures;Molecular;Monitor;mouse model;Mus;novel;Organoids;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;phase II trial;Phenotype;Policies;polymerization;Polymers;Population;predicting response;Prediction of Response to Therapy;Principal Investigator;Process;programs;Pulmonary Fibrosis;Pulmonary function tests;Refractory;regenerative;Regulatory T-Lymphocyte;Resolution;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Specificity;Specimen;STAT3 gene;Stat5 protein;Steroids;Structure of germinal center of lymph node;Suspensions;Syndrome;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;transplant survivor;treatment response;United States National Institutes of Health;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Bronchiolitis Obliterans: Discovery and Therapy


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Social networking sites (SNSs) represent both a potential barrier to alcohol use disorder (AUD) help-seeking behaviors among young adults, as well as a potentially innovative approach to facilitate AUD help-seeking among this population; however, there is little comprehensive understanding of the nature and impact of various exposures to AUD and AUD recovery-related SNS content. Pro-drinking exposures may contribute to decreases in perceived need for treatment due to the glamorization of heavy drinking behaviors, while on the other hand digital AUD recovery narratives emphasizing lived experience, strength, and hope may serve to normalize experiences of addiction and facilitate AUD help-seeking behaviors. This research career development award will provide the candidate with mentorship and hands-on training to systematically examine and characterize AUD and recovery-related exposures on Twitter in order to define prominent barriers to and facilitators of AUD recovery, as well to identify targets for later narrative-based intervention.

PI_NAMEs: RUSSELL, ALEX  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: addiction;Address;Adoption;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol related problem;alcohol seeking behavior;alcohol use disorder;Alcohols;American;Area;Attitude;Award;behavior change;Behavioral;Belief;career;career development;Caring;Characteristics;Cluster Analysis;Code;Communication;Communications Media;Computational Science;Consumption;Data;Data Collection;Development;diagnostic criteria;Diffusion;digital;drinking;drinking behavior;Educational workshop;effective therapy;evidence base;Evidence based treatment;experience;Exposure to;Fostering;Generations;Goals;Grant;Health;Health behavior;health communication;Heavy Drinking;help-seeking behavior;Individual;innovation;Intention;Intervention;Intoxication;K-Series Research Career Programs;Knowledge;Link;Lived experience;Manuals;Measurement;Media Intervention;Mentors;Mentorship;Methods;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Nature;news;novel;Outcome;outreach;Pathway Analysis;personal narratives;Persons;Population;Positioning Attribute;prevent;problem drinker;Process;Public Health;public health priorities;Published Comment;Recovery;recovery services;Recovery Support;Research;Research Methodology;Research Personnel;research study;Resources;Risk;Science;service engagement;Services;skills;social media;Social Network;social networking website;Source;Stigmatization;Structure;symposium;tailored messaging;Testing;Text;theories;therapy design;Training;Training Support;Treatment Effectiveness;treatment services;Twitter;unsupervised learning;uptake;Violence;Visualization;willingness;Work;young adult

PROJECT_TITLE: Characterizing alcohol use disorder recovery-related exposures on Twitter: Content, cluster, and network analysis

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative There are no effective vaccines or treatments for human parainfluenza virus (PIV) or metapneumovirus (MPV) infections; both are common causes of viral lower respiratory tract infections in children, immunocompromised adults and the elderly in the U.S., and are important causes of asthma exacerbations, bronchiolitis, and pneumonia. Here, we propose to engineer antibodies that can neutralize diverse strains of both viruses, trap them in mucus, and block their spread within the lung airways where both infections proliferate. If successful in validating their efficacy in vitro and in vivo, our work may provide a framework for developing novel treatments for other respiratory infections.

PI_NAMEs: LAI, SAMUEL  (contact);PICKLES, RAYMOND J

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Address;Adult;Affinity;Air;airway epithelium;Antibodies;antibody engineering;antigen binding;Apical;asthma exacerbation;Back;Binding;Biological Assay;Blood;Bronchiolitis;Caring;Cells;Child;Clinical;crosslink;Cytopathology;Diffuse;Dose;Ebola;effective therapy;efficacy testing;Elderly;Engineering;Epithelium;Evaluation;Functional disorder;Goals;Hamsters;Herpesvirus 1;Histology;Hour;Human;Human Metapneumovirus;Immune;Immunocompromised Host;Immunoglobulin G;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infant;Infection;Inflammation;Influenza;Inhalation;Inhalation Therapy;Intercept;Intervention;Lead;Libraries;Life Cycle Stages;Liquid substance;Lower Respiratory Tract Infection;Lung;Medical;Metapneumovirus;Methods;Modeling;molecular targeted therapies;Monoclonal Antibodies;Mucins;Mucociliary Clearance;Mucous body substance;Mucous Membrane;Mus;Nebulizer;Neonatal;neutralizing monoclonal antibodies;Neutrophil Infiltration;Nose;novel;Parainfluenza;parainfluenza virus;Particulate;pathogen;Pathologic;Pathology;Patients;Penetration;pharmacologic;Pneumonia;Polysaccharides;Proliferating;Property;Prophylactic treatment;Proteins;purge;Recombinants;Research Personnel;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;Structure of parenchyma of lung;Surface;Tissues;transmission process;Vaccines;Vagina;Viral;Viral load measurement;Viral Load result;viral RNA;Viremia;Virion;Virus;Virus Shedding;Work;Yeasts

PROJECT_TITLE: Engineered “muco-trapping” antibodies for inhaled therapy of parainfluenza and human metapneumovirus infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ORG_CITY: BANGOR

ORG_NAME: WABANAKI HEALTH AND WELLNESS

ORG_STATE: ME

PHR: OVERALL PUBLIC HEALTH NARRATIVE  Alzheimer’s disease, dementia, and cognitive impairment will soon have a major impact on American Indian communities. The life expectancies for American Indians have increased over the last 50 years by as much as 30 years, resulting in an increased number of older adults. The Wabanaki Native American Research Center for Health is the first such Center in the northeastern US since the program was founded in 2000. It will fill striking gaps in our knowledge of Alzheimer’s disease and related dementias and mild cognitive impairment among American Indian elders. It will also promote and expand the research and service capabilities of Wabanaki Public Health, a tribal public health district that is uniquely positioned to assume a leadership role in ameliorating health disparities experienced by the Wabanaki and other northeastern tribal communities.

PI_NAMEs: JOHANSSON, PATRIK LENNART;SOCKABASIN, LISA  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;Advocacy;African American;aged;Aging;aging related;Agreement;Alaska Native population;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian community;American Indian Population;American Indians;Area;care systems;Cherokee Indian;Cholesterol;Collaborations;college;Communities;Community Health;Dementia;dementia risk;Direct Costs;Disparity population;economic impact;Economics;Education;Elderly;Eligibility Determination;experience;Facilities and Administrative Costs;Faculty;Foundations;Future;Generations;Growth;Health;health data;health disparity;Healthcare Systems;high risk;Houlton;human old age (65+);Human Resources;human very old age (85+);Hypertension;Impaired cognition;improved;Infrastructure;Institution;Internships;Joints;Knowledge;Leadership;Life;Life Expectancy;life span;low socioeconomic status;Maine;Medicine;member;mid-career faculty;mild cognitive impairment;Morbidity - disease rate;mortality;Native American Research Center for Health;Non-Insulin-Dependent Diabetes Mellitus;Nonprofit Organizations;Obesity;older adult;Passamaquoddy;Penobscot;Philosophy;Physical activity;Play;Population;Population Growth;Positioning Attribute;Prevalence;Principal Investigator;programs;Public Health;public health research;Regulation;repository;Research;Research Institute;Research Methodology;Research Project Grants;Resolution;Role;role model;Services;Smoking;social;Societies;Source;statistics;Students;Teton Sioux Indian;Training;transmission process;tribal community;tribal health;tribal member;tribal Nation;tribal organization;Tribes;undergraduate student;Underrepresented Populations;United States Public Health Service;Universities;virtual;Washington

PROJECT_TITLE: Wabanaki NARCH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: SOCKABASIN, LISA  (contact)

PROJECT_TERMS: Address;African American;Agreement;American Indians;Annual Reports;Appointment;Articulation;Awareness;Budgets;Cherokee Indian;Collaborations;collaborative approach;college;Communication;Communities;Community Health;Consult;data sharing;Doctor of Philosophy;Education;Elderly;Eligibility Determination;Ensure;Evaluation;experience;Faculty;Funding;Goals;Grant;Health;health assessment;health disparity;Houlton;Human Resources;implementation facilitation;Institution;intertribal;Investigation;Leadership;Life Cycle Stages;Maine;Manuscripts;Medicine;meetings;member;mid-career faculty;Monitor;National Institute of General Medical Sciences;Native American Research Center for Health;Nonprofit Organizations;Office of Administrative Management;operation;Oral;Passamaquoddy;Peer Review;Penobscot;Policies;population based;Positioning Attribute;Preparation;Principal Investigator;Process;programs;Public Health;Public Health Practice;Qualifying;Regulation;Research;Research Institute;Research Methodology;Research Project Grants;Research Support;Scholarship;Services;Training;Travel;tribal community;tribal member;Tribes;underserved community;United States National Institutes of Health;United States Public Health Service;Universities;Washington;Writing

PROJECT_TITLE: Wabanaki NARCH Admin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Tuberculosis (TB) is prevalent in Uganda, and overlaps with an already high burden of HIV/TB coinfection. The proposed data science – based project could help untangle factors of the host, pathogen and environment underlying TB, hence contributing to halting of TB transmission in the community.

PI_NAMEs: KATEETE, DAVID PATRICK (contact);NAKATUMBA, JOYCE NABENDE

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Age;Algorithms;Antibiotics;Antitubercular Agents;Artificial Intelligence;Body mass index;Capital;Caring;case finding;Cities;Clinical;clinically relevant;co-infection;cohort;Colony-forming units;Communicable Diseases;Communities;comorbidity;computer infrastructure;computer scientist;Consumption;cost;cytokine;Data;Data Science;Data Scientist;Data Set;Databases;deep learning model;Diagnostic;Disease;diverse data;Drug resistance;Early identification;Ensure;Environment;Epidemiologist;Exposure to;feature selection;Feces;Gender;Grouping;health data;Health Priorities;high risk;High-Throughput DNA Sequencing;HIV;HIV/AIDS;HIV/TB;Hospitals;Household;Image;indexing;Individual;innovation;insight;Integration Host Factors;International;Intervention;Interviewer;Laboratories;learning algorithm;low income country;Machine Learning;machine learning algorithm;machine learning model;Medicine;Methods;microbiome;Modeling;Molecular;multidisciplinary;Mycobacterium tuberculosis;non-compliance;Outcome;Participant;pathogen;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physicians;Population;Process;Questionnaires;Research;Research Personnel;Resistance;Ribosomal RNA;Risk;Risk Factors;Sampling;Science;Scientist;social;social factors;Sputum;Structure;supervised learning;support vector machine;Symptoms;Techniques;Thoracic Radiography;transmission process;Treatment Failure;Treatment outcome;treatment response;Trees;Triage;Tuberculosis;tuberculosis treatment;Uganda;Universities;unsupervised learning;Whole Blood;whole genome;X-Ray Medical Imaging

PROJECT_TITLE: Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on TB transmission and treatment response (DS-IAFRICA-TB)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a significant socioeconomic burden in the United States and worldwide, with few effective therapeutic interventions. Alcohol disrupts mitochondrial homeostasis and induces inflammation activation, underlying the progression of ALD. This proposal will not only uncover, for the first time, an important role of PDK4 in connecting the mitochondrial regulation of ethanol metabolism to inflammation activation, but also allow the applicant to acquire efficient knowledge and skills in the pathogenesis of ALD, which is highly relevant to NIAAA’s mission to provide support and protected time for a mentored career development experience in the biomedical science leading to research independence.

PI_NAMEs: WU, JIANGUO  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Abstinence;Academia;Acetaldehyde;Acetyl Coenzyme A;Acute Alcoholic Hepatitis;Address;Advisory Committees;Affect;alcohol abstinence;Alcohol consumption;alcohol exposure;alcohol research;alcohol response;Alcoholic Liver Diseases;Alcohols;Animal Model;Apoptosis;Apoptotic;Arsenic;attributable mortality;Biochemistry;Bioenergetics;Biological Assay;Biology;career development;Cell Death;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;Chronic;Cirrhosis;Citric Acid Cycle;Cleavage Under Targets and Release Using Nuclease;Data;Development;Diagnostic;Diethylnitrosamine;Disease;Drug Metabolic Detoxication;Economic Burden;effective therapy;Enzymes;Ethanol;Ethanol Metabolism;Ethanol toxicity;Event;Excision;experience;experimental study;fatty acid metabolism;Fatty Liver;feeding;Fibrosis;Gene Expression;Gene Expression Regulation;Genes;global health;Glucose;Goals;Health;Health Expenditures;Healthcare;Heavy Drinking;Hepatic;Hepatitis C virus;Hepatocyte;Histologic;Homeostasis;Human;Immune;Immunology;Impairment;improved;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insulin sensitivity;interest;Interleukin-1 beta;Intervention;Isoenzymes;knock-down;Knowledge;Link;lipid metabolism;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;liver injury;Liver Regeneration;liver transplantation;Location;Macrophage;Malignant neoplasm of liver;Malignant Neoplasms;Marker Discovery;Mediating;Mediator;member;Mentors;metabolomics;Methods;Mission;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Matrix;Molecular;monocyte;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Natural regeneration;non-alcoholic fatty liver disease;novel marker;novel therapeutics;Nuclear;overexpression;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Patients;PDH kinase;Peripheral Blood Mononuclear Cell;pharmacologic;Phenotype;Positioning Attribute;prevent;prognostic;Proteins;Proteomics;Public Health;Publishing;Pyruvate;Pyruvate Dehydrogenase Complex;pyruvate dehydrogenase kinase 4;Regulation;Research;Resources;Role;Science;Scientist;skills;socioeconomics;Steatohepatitis;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissues;TNF gene;Toxic effect;Training;United States;welfare

PROJECT_TITLE: The role of PDK4 in alcohol-associated liver disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: JOHANSSON, PATRIK LENNART (contact)

PROJECT_TERMS: Age;aged;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indian community;American Indian Population;American Indians;Area;billing data;care burden;Caring;case control;Cause of Death;Chronic;Clinical;clinical database;clinical diagnostics;Cognitive;cognitive function;Communities;Contracts;cost;Country;Data;Dementia;dementia risk;detection platform;Development;Diagnosis;Direct Costs;disparity elimination;economic cost;economic evaluation;Elderly;epidemiology study;ethnic minority;Evaluation;experience;Facilities and Administrative Costs;Failure;Funding;Future;General Population;Health;health care availability;health care quality;health data;health economics;Health Status;Healthcare;Heterogeneity;human old age (65+);Human Subject Research;human very old age (85+);Hypertension;Impaired cognition;informal caregiver;Intervention;Interview;Life Expectancy;Life Style;Light;Maine;Measures;mild cognitive impairment;Morbidity - disease rate;Native American Research Center for Health;Native-Born;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;older adult;Participant;Persons;PF4 Gene;Population;population based;Population Study;Prevalence;prevent;Probability;Provider;Public Health;public health intervention;racial minority;Research;Research Design;Research Personnel;Research Project Grants;response;Risk Factors;screening;Screening Result;service delivery;Services;System;systematic review;text searching;trend;tribal community;tribal health;tribal member;Tribes;United States Indian Health Service;Universities;validation studies;Voice;Washington

PROJECT_TITLE: The Voices of our Elders


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Effective, cost-effective, scalable, and sustainable implementation strategies to improve care for rheumatic heart disease (RHD) in low-income countries are urgently needed. Our study will refine a contextually-adapted RHD program (ADUNU) aimed at achieving guideline-based care for RHD in Uganda through an integrated, community-centered approach. A robust mixed-methods design will evaluate the success of the program and determine the cost-effectiveness and affordability of the program.

PI_NAMEs: BEATON, ANDREA ZAWACKI (contact);WATKINS, DAVID A

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: 15 year old;Acceleration;Adherence;Adopted;Adoption;aged;Antibiotic Prophylaxis;Awareness;Benzathine Penicillin;budget impact;Cardiac;Cardiovascular Diseases;Cardiovascular system;Caring;Charge;Child;Clinical;Communities;community engaged research;community setting;community-centered;cost;cost effective;cost effectiveness;cost estimate;cost-effectiveness evaluation;Country;Data;Decentralization;design;Detection;Diagnosis;Dimensions;disease registry;disorder control;Echocardiography;Effectiveness;Endemic Diseases;Enrollment;Evaluation;evidence base;Evidence based practice;experience;experimental study;Failure;Foundations;Funding;Goals;Government;Guidelines;Health;health care delivery;Health care facility;health data;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Systems;Heart;Heart Diseases;HIV;Hospital Referrals;Hospitals;implementation determinants;implementation strategy;improved;Individual;Injections;innovation;insight;Intervention;Interview;Intramuscular;Investments;Light;low and middle-income countries;low income country;Maintenance;Maps;marginalized population;mathematical model;Measures;Methods;microcosting;Modeling;neglect;novel;Nurses;Observational Study;Outcome;Outcomes Research;Patient-Focused Outcomes;Patients;Penicillin G;Persons;Population;Prevalence;prevent;prevention service;preventive intervention;Primary Health Care;program costs;programs;Prophylactic treatment;prospective;Protocols documentation;Provider;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Registries;Research;Research Infrastructure;Resolution;Resource-limited setting;Resources;Rheumatic Heart Disease;routine practice;Running;scale up;Secondary Prevention;Service delivery model;Subgroup;success;System;Technology;Testing;Time;tool;Training;Travel;Uganda;uptake;Work;World Health;young adult

PROJECT_TITLE: Accelerating Delivery of rheumatic heart disease preventive iNterventions in Uganda (ADUNU)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Cardiovascular disease (CVD) is the leading cause of death among people living with HIV (PLWH) receiving antiretroviral therapy (ART) and there is ~2-fold greater risk for CVD events in PLWH compared to the risk among HIV- individuals. We propose to measure the transcriptional, phenotypic and functional capabilities of monocyte derived macrophages and compare them to the transcriptomic profiles of plaque derived macrophages in PLWH and in HIV negative individuals. We hypothesize that ART, directly and indirectly through alteration of the lipidome, contributes to macrophage activation in PLWH and subsequently to increased CVD risk.

PI_NAMEs: CAMERON, MARK JAMES;FUNDERBURG, NICHOLAS T. (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: antiretroviral therapy;Arterial Fatty Streak;Atherosclerosis;Biological Assay;Biological Markers;Blood;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Endarterectomy;Cause of Death;CD14 gene;Cells;Cessation of life;Classification;Clinical;clinically relevant;Complex;coronary artery calcification;Data;Data Set;Dimensions;Disease;Disparate;Event;experimental study;Exposure to;fatty acid oxidation;Fatty Acids;FCGR3B gene;Gene Expression;Gene Expression Profile;Genetic Transcription;HIV;HIV Seronegativity;Homing;immune activation;Immune signaling;Immunologics;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;Interleukin-6;Leukocytes;Link;lipidome;lipidomics;Lipids;Macrophage;Macrophage Activation;Matrix Metalloproteinases;Measures;Mediator;Mitochondria;mitochondrial dysfunction;Modeling;monocyte;mortality;multiple omics;Myeloid Cell Activation;Nucleosides;Outcome;Oxidative Phosphorylation;Participant;Pathogenesis;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Polyunsaturated Fatty Acids;Population;pre-exposure prophylaxis;Prevalence;Production;recruit;Reverse Transcriptase Inhibitors;Risk;Saturated Fatty Acids;Signal Transduction;Sorting;Testing;Therapeutically Targetable;TNFRSF1A gene;transcriptomics;United States;uptake;Viral;Work

PROJECT_TITLE: Plaque and blood derived macrophages: a multi-omic assessment of CVD pathogenesis in PLWH

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Palliative Care;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is consistent with broader public health goals focused on improving patient end-of-life care and the College of Surgeons Commission on Cancer and Centers for Medicare and Medicaid Services (CMS) call for increased patient engagement in advance care planning (ACP) as part of standard care. The proposed study will address this public health issue by developing and pilot testing a mobile application (Planning Advance Care Together, PACT) designed to improve advanced cancer patients’ levels of engagement in ACP, documented ACP conversations with doctors and family members, completion of advance directives, and receipt of goal-concordant care by integrating family members/loved ones (i.e., “caregivers”) and providers into the ACP decision-making process. Therefore, this study is aligned with the NCI’s long-term goals of improving quality of care at the end of life and the CMS’s goal of improving engagement in ACP.

PI_NAMEs: SHEN, MEGAN JOHNSON (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Advance Care Planning;advanced directive;Advanced Malignant Neoplasm;Benchmarking;Cancer Patient;care preference;Caregivers;Caring;cohort;Collaborations;college;Control Groups;coping;Decision Making;Decision Theory;design;Development;Documentation;effective intervention;end of life;end of life care;Exercise;Family;Family Caregiver;Family member;Feedback;field study;Funding;Goals;group intervention;health goals;Health Technology;Healthcare;improved;Individual;informant;Intervention;intervention refinement;Interview;iterative design;Living Wills;loved ones;Malignant Neoplasms;meetings;mHealth;mobile application;Mobile Health Application;neglect;novel strategies;Oncologist;Outcome Assessment;Participant;Patient Education;patient engagement;Patient Preferences;patient subsets;Patients;pilot test;pilot trial;post intervention;preference;primary outcome;Process;Process Measure;Protocols documentation;prototype;Provider;Proxy;Public Health;Quality of Care;Quality of life;Randomized;Reporting;Research;Research Personnel;satisfaction;Science;secondary outcome;Shapes;social;Social Environment;Social Network;Social Planning;social relationships;Social support;Social Workers;standard care;Structure;Surgeon;Technology;Testing;treatment as usual;Treatment Efficacy;United States Centers for Medicare and Medicaid Services;usability;Work

PROJECT_TITLE: Planning Advance Care Together (PACT) to Improve Engagement in Advance Care Planning among Advanced Cancer Patients

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Suicide

ORG_CITY: SYRACUSE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE The overarching objective of this proposal is to identify how the policies U.S. states enacted to combat the spread and adverse effects of COVID-19 may have affected psychological health and mortality from drug overdose and suicide among working age and older adults in both the immediate and longer terms. The project will provide novel large-scale data on adult COVID-19 experiences and wellbeing and use the variation in policy responses across states to shed light on which policies and combinations of policies are consequential for adult psychological health and related mortality, the mechanisms through which policies affect those outcomes, and the population subgroups that are disproportionately affected. The overall findings will be essential for informing optimal policy responses in future pandemics.

PI_NAMEs: MONNAT, SHANNON M (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Adult;Adverse effects;adverse outcome;Affect;Age;age difference;age group;aged;base;Bayesian Modeling;Black Populations;Buffers;Businesses;Cause of Death;Collaborations;combat;Conflict (Psychology);County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 prevention;COVID-19 severity;Data;Data Correlations;Data Reporting;Data Set;Death Rate;design;Deterioration;Disparity;Economics;Education;Employment;Ethnic Origin;experience;Family;Financial Hardship;Funding;future pandemic;Gender;Geography;Health;health care availability;Health Personnel;Healthcare;high dimensionality;Individual;innovation;large scale data;Life Cycle Stages;Living Arrangement;Measures;Medicaid;member;Mental Depression;Mental Health;Methods;mortality;Natural experiment;Not Hispanic or Latino;novel;older adult;Outcome;Overdose;pandemic disease;Patient Self-Report;Personal Satisfaction;Persons;Pharmaceutical Preparations;Play;Policies;Population;Race;Reporting;response;Risk;SARS-CoV-2 infection;Schools;self-reported anxiety;sex;Sleep Disorders;social;Social isolation;social relationships;stay-at-home order;Subgroup;substance use;Suicide;suicide mortality;suicide rate;Surveys;System;trend;Unemployment;Variant;Vital Statistics;Work

PROJECT_TITLE: States' COVID-19 Mitigation Policies and Psychological Health, Drug Overdose, and Suicide among U.S. Adults


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: PETRIE, REBECCA  (contact)

PROJECT_TERMS: Academia;Acceleration;Accreditation;Address;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;American Indian community;American Indian Population;American Indians;Area;Awareness;Behavioral Risk Factor Surveillance System;Biometry;career;cognitive function;Collaborations;Communities;Data;Data Analyses;data management;data visualization;disorder prevention;E-learning;Education;Educational Curriculum;Elderly;Employee;Employee Health;Epidemiology;Exercise;experience;Faculty;follow-up;Fostering;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;Health Occupations;Health Priorities;Health Promotion;Health Sciences;Health Status;Health Surveys;Helicopter;Hour;Ideal 1;Individual;Infrastructure;interest;Internships;Lead;Learning;Maine;member;Mentors;Native American Research Center for Health;non-Native;novel;Passamaquoddy;Personal Satisfaction;Population;Positioning Attribute;Principal Investigator;programs;Public Health;Publishing;Qualitative Research;Readiness;Recording of previous events;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Running;Secure;Self Determination;skills;Strategic Planning;Surveys;synchronous delivery;Training;tribal health;tribal member;Tribes;undergraduate student;United States National Institutes of Health;Universities;university student;videoconference;Washington;Work;Writing;young adult

PROJECT_TITLE: Wabanaki Grants, Epidemiology, Analysis, Research Design, and Undergraduate Program


NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Asthma and sleep disordered breathing (SDB) are common chronic diseases that disproportionately affect Black children and those living in poor neighborhoods. The indoor environment has been shown to impact childhood asthma and it is highly plausible that bedroom environmental exposures contribute to upper airway inflammation and sleep quality but studies that include objective environmental exposure and sleep assessment are needed. This study will define the association between bedroom environmental exposures, including air quality, allergens, and microbes, and sleep quality among inner-city children with asthma, providing key foundational evidence necessary to design home environmental interventions in order to reduce sleep and asthma disparities.

PI_NAMEs: MCCORMACK, MEREDITH C (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;Adult;Affect;African American;Air;air monitoring;Air Pollutants;Air Pollution;airway inflammation;Allergens;ambient air pollution;Asthma;Bacteria;Baltimore;Beds;Biological;biological adaptation to stress;Biological Markers;Black race;Child;Childhood;Childhood Asthma;Chronic Disease;Cities;cockroach allergen;Collection;Data;design;Disparity;disparity reduction;Dust;Emergency Situation;Environment;Environmental Exposure;environmental intervention;Environmental Monitoring;Environmental Science;environmental tobacco smoke;Epidemiology;experience;Exposure to;follow-up;Goals;health assessment;health disparity;High Prevalence;Home;Home environment;Hospitalization;Household;household environmental exposure;Individual;Indoor Air Quality;Indoor environment;indoor particulate matter;Inflammation;Inflammatory;inner city;Intervention;Link;Liquid substance;Literature;Low income;Lung;Measures;Mediating;Mediator;Medicine;Microbe;microbial;Microbiology;Monitor;Morbidity - disease rate;mouse allergen;multidisciplinary;Nasal Epithelium;Needs Assessment;Neighborhoods;Nitrogen Dioxide;Nocturnal Asthma;Nose;Outcome;Oxidative Stress;Particulate Matter;Patient Self-Report;poor sleep;Proteins;pulmonary function;Questionnaires;Recommendation;Reporting;Research;Risk;Severities;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep quality;Spirometry;Staphylococcus aureus;Symptoms;Thailand;therapeutic target;therapy design;Time;urban setting;Visit;Work;World Health Organization

PROJECT_TITLE: Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-Z(02)]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE In numerous human diseases the insulating layer around nerves in the brain, called myelin, is damaged and must be efficiently cleared before tissue repair can occur. We have developed advanced methodologies for inducing, manipulating and observing myelin degeneration and repair in the live brain in real time. Using these tools this project will investigate how myelin debris are dynamically cleared by resident glial cells and the consequences of defective clearance on tissue maintenance and myelin repair.

PI_NAMEs: HILL, ROBERT  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Aging;Animal Model;Animals;Apoptotic;Astrocytes;Axon;Brain;Cell Death;Cell membrane;Cell Surface Extensions;cell type;Cells;Cellular Structures;Cessation of life;Color;Communication;CSPG4 gene;Degenerative Disorder;Demyelinating Diseases;Demyelinations;Detection;Development;Digestion;Event;Excision;experience;experimental study;Failure;Fluorescence;fluorophore;Functional disorder;Generations;Genetic;genetic manipulation;gray matter;human disease;human model;Image;imaging modality;Imaging Techniques;Impaired cognition;in vivo;in vivo imaging;Injury;intravital imaging;Investigation;Knowledge;Label;Lipids;Maintenance;Metabolic;Metabolism;Methodology;Methods;Microglia;Modeling;Molecular;motor impairment;Multiple Sclerosis;Mus;Mutant Strains Mice;Mutation;Myelin;myelin degeneration;Myelin Sheath;Nerve;neural;neural circuit;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;Oligodendroglia;optical imaging;Organ;Pathway interactions;Pattern;Phagocytes;Phagocytosis;phosphatidylserine receptor;Play;Population;Process;progenitor;receptor;Receptor Signaling;remyelination;repaired;Reporter;Resolution;response;Rest;Role;Sensory;Signal Transduction;Specific qualifier value;Speed;Stereotyping;success;Techniques;Testing;Time;tissue repair;Tissues;tool;Transgenic Organisms;transmission process;TREM2 gene

PROJECT_TITLE: Glial Mechanisms Governing the Removal and Repair of Degenerating Myelin

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative The long-term goal of this work is study and reverse engineer how cells interact with their environment. To do this, we pay special attention to the cell-material interface by varying the physical chemistry of cell interacting ligands. Specifically, we study how ligand design features can be manipulated to facilitate a programmable response such as bone formation.

PI_NAMEs: GORMLEY, ADAM JOSEPH (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Attention;Avidity;Biocompatible Materials;Biophysics;cell behavior;Cell Communication;Cells;Characteristics;combinatorial;Complement;Complex;design;Environment;Extracellular Matrix;Goals;Knowledge;Learning;Ligands;Modeling;molecular dynamics;nano;nanomedicine;nanoscale;Osteogenesis;Physical Chemistry;programs;Quantitative Structure-Activity Relationship;receptor;Regenerative Medicine;Research;response;Reverse engineering;Science;Shapes;Signal Transduction;Specificity;Structure;superresolution microscopy;Surface Plasmon Resonance;Work

PROJECT_TITLE: Tuning multivalency for optimized ligand presentation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;American Indian community;American Indian Population;American Indians;Area;Communities;community based research;community engagement;Community Health;Consent;cultural competence;Data;data integrity;data sharing;design;Education;Ensure;Ethics;federal policy;fly;Funding;Future;Future Generations;Government;Grant;Health;health disparity;health organization;Helicopter;Houlton;human subject;human subject protection;Human Subject Research;improved;Individual;Institutional Review Boards;interest;Knowledge;Laws;Leadership;Light;Maine;Mainstreaming;member;Native American Research Center for Health;Native-Born;Ownership;Passamaquoddy;Pathway interactions;Penobscot;Persons;Policies;Policy Compliance;Poverty;Procedures;Process;Public Health;public health research;Publications;Regulation;Research;Research Institute;Research Personnel;Reservations;responsible research conduct;Rewards;Rural;social group;Social Protection;Specimen;Standardization;stem;Stigmatization;Terminology;tribal community;Tribal Council;tribal health;tribal member;tribal organization;Tribes;Trust;United States Public Health Service;Universities;urban Native American;Washington

PROJECT_TITLE: Wabanaki Research Review Board


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE We propose to develop highly multiplexed immunofluorescence super-resolution imaging tools. Our approach is fast, low cost and readily accessible, which will facilitate nanoscale imaging-based proteomics in cells and tissues.

PI_NAMEs: HAN, KYU YOUNG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Area;Bar Codes;Biochemical;Brain;Cells;Complex;Confocal Microscopy;Consumption;cost;deep learning;design;Disease;DNA;Fluorescence;Hour;Image;imager;imaging capabilities;Imaging Device;Immunofluorescence Immunologic;In Situ;Label;Location;Malignant Neoplasms;Methods;Microscopy;multiplexed imaging;nanobodies;nanoscale;Nanoscopy;open source;Optics;parallelization;Photons;Play;Process;protein profiling;Proteins;Proteomics;Resolution;Role;Signal Transduction;Structure;superresolution imaging;Time;Tissues;tool;ultra high resolution

PROJECT_TITLE: Super-multiplexed fluorescence nanoscopy for imaging-based proteomics


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Recent work in human genetics has revealed much about patterns of genetic variation for genetically complex traits within the human population. However, interpreting these patterns requires that we understand the evolutionary processes that gave rise to them. Our research group will develop mathematical models of complex trait evolution and accompanying statistical inference approaches in order to learn about the forces shaping genetic variation in complex triats.

PI_NAMEs: BERG, JEREMY JACKSON (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Population genetic modeling of genetic variation for complex traits and diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Atrial fibrillation is the most common sustained arrhythmia, and is the cause of significant morbidity and mortality. This proposal aims to elucidate the role of endothelial dysfunction - a prominent feature of multiple risk factors for atrial fibrillation - in the development of an arrhythmogenic substrate leading to atrial fibrillation, which will allow the emergence of mechanism-guided therapies. Given the rapidly increasing prevalence of atrial fibrillation and the limited efficacy of current therapies for this disease, it is in the interest of public health to better understand the molecular mechanisms leading to atrial fibrillation.

PI_NAMEs: PFENNIGER, ANNA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Age;Animal Model;Animals;Arrhythmia;Atrial Fibrillation;autonomic nerve;Award;Biology;Blood;Blood Vessels;canine model;Canis familiaris;Cardiac ablation;cardiac magnetic resonance imaging;Cardiac Myocytes;cardiovascular imaging;Cardiovascular system;Chronic;Clinical;clinically relevant;Coronary;Coupling;Data;Development;Diabetes Mellitus;Disease;Economic Burden;Electrophysiology (science);endothelial dysfunction;Endothelin A Receptor;Endothelin-1;Endothelium;Enzymes;Epidemic;Fatty acid glycerol esters;Fibrosis;Future;G-Protein-Coupled Receptors;Gene Expression;gene therapy;Generations;Genes;Genetic;Goals;GTP-Binding Protein alpha Subunits, Gs;Heart;Heart Atrium;Heart failure;heart rhythm;Human;Hypertension;improved;Inflammatory;interest;International;ITPR1 gene;K-Series Research Career Programs;Kidney;Left;Left atrial structure;Lung;Mentors;Mentorship;Microvascular Dysfunction;MLLT6 gene;Modeling;Molecular;Morbidity - disease rate;mortality;Muscle Cells;Myocardium;National Heart, Lung, and Blood Institute;Nerve;Nerve Growth Factors;novel;novel therapeutics;Pathway interactions;Patients;Peptides;pharmacologic;Physicians;Prevalence;prevent;professor;Profibrotic signal;programs;Proteins;Public Health;regional difference;Research;Research Institute;Risk Factors;Role;Scientist;Secondary to;Signal Pathway;Signal Transduction;skills;sleep health;small hairpin RNA;socioeconomics;Spatial Distribution;spatial relationship;Strategic vision;Stroke;Testing;Time;tool;translational potential;United States National Institutes of Health;Universities;Ventricular;Work

PROJECT_TITLE: Role of Endothelin-1 signaling in the development and progression of atrial fibrillation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The Drexel FIRST initiative (Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research) will create a collaborative structure involving University leaders, academic units and faculty to catalyze sustainable institutional change that supports scientific and inclusive excellence in the conduct of health disparities research. We will recruit 10 diverse early career scientists, support their career development, create sustainable institutional changes necessary to promote inclusive excellence broadly, and evaluate the outcomes of the program at multiple levels including scientific impact.

PI_NAMEs: DIEZ ROUX, ANA VICTORIA (contact);GITLIN, LAURA N.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;African American;Aging;Applications Grants;Appointment;Area;Biometry;career;Career Choice;career development;Chronic Disease;clinical practice;Clinical Research;Collaborations;college;Color;Communities;Complex;Dedications;Discipline of Nursing;Disparity;Documentation;Effectiveness;Ensure;Equity;ethnic diversity;Ethnic Origin;Evaluation;evidence base;experience;Extramural Activities;Faculty;faculty support;Funding;Gender;Goals;Health Disparities Research;health disparity;health equity;health inequalities;Health Occupations;improved;Individual;Inequity;Infrastructure;Institution;International;intersectionality;Intervention;Intervention Studies;Joints;Latino;learning community;Life Cycle Stages;Measures;Mentors;Mentorship;Methodology;Methods;multi-component intervention;multidisciplinary;novel;Outcome;pedagogy;Policies;population health;Population Sciences;Positioning Attribute;Procedures;Program Evaluation;Program Sustainability;programs;Public Health Schools;Race;racial diversity;Records;recruit;Research;research and development;Research Personnel;Research Proposals;Research Support;response;Science;Scientist;Social Justice;Social Values;Structure;success;Teacher Professional Development;tenure track;theories;therapy development;Translating;underserved community;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Cancer;Genetics

PHR: PROJECT NARRATIVE The Never in mitosis A-related kinase (NEK) family of protein kinases is an important, yet understudied, kinase family that has recently been implicated in a variety of disorders, including numerous cancers, ciliopathies, chronic inflammatory diseases, and neuronal disorders. The lack of reliable tools to study NEK function has made it difficult to determine the specific role(s) that NEK family members play in the etiology and progression of these diseases. In the proposed project, we will use a generalizable, family-based strategy to develop a suite of tools, including high quality chemical probes, that will be made freely available to the biomedical researcher community and enable researchers to build a firm understanding of how these understudied kinases contribute to health and disease and validate new druggable targets for cancer drug discovery.

PI_NAMEs: BUROW, MATTHEW E.;DREWRY, DAVID HAROLD (contact);NEWMAN, ROBERT HOWARD

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Active Sites;Address;Antineoplastic Agents;Binding;Biological;Biological Assay;Biological Process;Biology;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell Line;cell motility;Cells;Cellular biology;Chemicals;chronic inflammatory disease;ciliopathy;cilium biogenesis;Communities;Data;design;Development;Diabetes Mellitus;Disadvantaged;Disease;Disease Progression;DNA biosynthesis;DNA Damage;drug development;drug discovery;drug quality;Drug Targeting;druggable target;Environment;Etiology;Family;Family member;FDA approved;Foundations;Free Will;Funding;Generations;Genome;Health;holistic approach;Human;Individual;Inflammation;Inflammatory Bowel Diseases;inhibitor;insight;kinase inhibitor;knock-down;Knock-out;Knowledge;lead optimization;Left;Link;Malignant Neoplasms;Measures;Medicine;member;migration;Mission;Mitosis;Modality;Molecular;Nature;Neurons;new therapeutic target;Oncology;Output;Pathologic;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Physiological;Play;Process;programs;Proliferating;Protein Family;Protein Kinase;Proteins;Proteome;Reagent;Reporter;Research;Research Personnel;Resources;response;RNA Splicing;Role;scaffold;Scientist;Signal Pathway;Signal Transduction;small molecule;success;System;Therapeutic;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Identification and characterization of chemical probes for interrogation of the NEK family of kinases in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DIEZ ROUX, ANA VICTORIA (contact)

PROJECT_TERMS: Accountability;Address;Area;career;cohort;college;Communication;design;Development;Discipline of Nursing;Effectiveness;Ensure;Environment;Evaluation;Evidence based practice;Faculty;Funding;Goals;Growth;Health;Health Disparities Research;health disparity;health disparity populations;Health Occupations;higher education;improved;Infrastructure;Institution;Intervention;Intervention Studies;Leadership;medical schools;Medicine;Mentors;minority disparity;minority health;Modeling;organizational structure;Pennsylvania;population health;Population Intervention;Population Sciences;Process;Program Sustainability;programs;Public Health Schools;recruit;Research;Research Personnel;Role;Science;Scientist;Strategic Planning;Structure;success;Teacher Professional Development;Testing;United States National Institutes of Health;Universities;Update;Woman;Work

PROJECT_TITLE: Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]