NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Public Health Relevance In this proposal, our collaborative team will study for the first time the detailed molecular structure of mammalian prions (the unorthodox infectious agents responsible for neurological diseases such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy) using high-resolution analytical techniques. Specifically, we will determine how essential cofactor molecules enable the prion protein to change its shape into an infectious form. The results of this research will help us visualize in molecular detail the process by which prion proteins replicate and thereby facilitate the development of rational therapies and diagnostic tools for prion diseases.

PI_NAMEs: SUPATTAPONE, SURACHAI  (contact);ZILM, KURT WILLIAM

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Alzheimer's Disease;Amino Acids;Animals;beta pleated sheet;Biochemical;Biological;Bovine Spongiform Encephalopathy;Chemicals;cofactor;conformer;Coupling;Creutzfeldt-Jakob Syndrome;Data;Development;diagnostic development;diagnostic tool;Digestion;Dissociation;Electron Microscopy;Elements;Endopeptidase K;experimental study;Goals;Human;In Vitro;Infectious Agent;Isotope Labeling;Isotopes;Laboratories;Link;Livestock;Maintenance;Maps;Mass Spectrum Analysis;Measurement;Membrane Lipids;Methods;Modeling;Molecular;Molecular Conformation;Molecular Structure;Nervous System Disorder;Neurodegenerative Disorders;novel;Nuclear Magnetic Resonance;Parkinson Disease;Pathogenesis;pathogenic isoform;Pattern;Phosphatidylethanolamine;Positioning Attribute;Prion Diseases;Prions;Process;Property;protein misfolding;protein protein interaction;protein structure;Protein Subunits;Proteins;PrP;public health relevance;recombinant PrP;Recombinants;Registries;Research;Resolution;Role;Sampling;Shapes;Side;solid state nuclear magnetic resonance;Structural Models;Structure;System;Techniques;Time;Vaccines;Variant;Vertebral column;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Structural Mechanism of Mammalian Prion Infectivity

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-M]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Significant associations have been noted between the aberrant expansion of blood cells with somatic mutations in TP53 or PPM1D and prior exposure to cancer treatments. These mutational events may increase the risk of cardiovascular disease, but causal data linking these mutations in cancer survivors with cardiovascular disease does not exist. The proposed experiments will experimentally examine whether amplification of TP53/PPM1D mutant clones in blood worsens cancer therapy-related damage to the heart, using an anthracycline drug as a test case.

PI_NAMEs: WALSH, KENNETH  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Address;age related;Aging;Animal Model;Anthracycline;Antineoplastic Agents;Biological Assay;Biological Models;Blood;Blood Cells;Cancer Patient;Cancer Survivor;cancer therapy;Cardiology;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;Cell Culture Techniques;Cell Physiology;Cells;Cessation of life;chemokine;chemotherapy;Chemotherapy and/or radiation;Clinical;clinically relevant;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;conditional mutant;Congestive Heart Failure;cytokine;Cytotoxic Chemotherapy;Data;Development;Disease;DNA Sequence Alteration;DNMT3a;Doxorubicin;Elderly;Epigenetic Process;Event;Exhibits;exome sequencing;experimental study;Exposure to;fitness;Frequencies;Gene Mutation;Genes;Genotoxic Stress;Heart;Heart Diseases;Heart failure;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;Immune;in vivo;Individual;Inflammation;Inflammatory;insight;irradiation;Link;Malignant Neoplasms;Mediating;Modeling;Molecular;Mosaicism;mouse genetics;mouse model;Mus;mutant;Mutate;Mutation;Myeloid Cells;Myocardial dysfunction;neutrophil;Neutrophil Activation;novel;novel therapeutics;Outcome;overexpression;Patients;Pharmaceutical Preparations;PPM1D gene;preclinical study;prevent;Probability;Process;Prognosis;Property;Protocols documentation;Resistance;Role;Sampling;Somatic Mutation;Survivors;targeted treatment;Testing;therapy design;Time;Toxic effect;TP53 gene;Treatment-Related Cancer

PROJECT_TITLE: Role of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicity

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE The generation of methods for parallel and single molecule sequencing of peptides/proteins promises a revolution in proteomic analyses. Fluorosequencing is the only method currently reported to give peptide sequence information in parallel and on a single molecule level. Several improvements to this technique will bring it to the forefront of proteomic methods for health and disease state diagnostics.

PI_NAMEs: ANSLYN, ERIC V. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Amino Acids;base;BODIPY;C-terminal;Chemicals;Chemistry;Collaborations;Databases;design;Diagnostic;Disease;Dyes;Fluorescence Resonance Energy Transfer;fluorophore;Generations;Genomics;Health;imaging modality;improved;Individual;Label;Lysine;Methods;Methylation;Microscope;N-terminal;nanopore;Nucleic acid sequencing;Peptide Sequence Determination;Peptides;Positioning Attribute;Post-Translational Protein Processing;protein aminoacid sequence;Protein Analysis;Proteins;Proteomics;Reporting;Running;Sampling;sequencing platform;Series;single molecule;Techniques;Technology;Time;Ubiquitination;Work

PROJECT_TITLE: Facilitating the Chemistry of Fluorosequencing


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Both borderline and avoidant personality disorders are marked by profound impairments in interpersonal functioning. However, the brain mechanisms underlying these social deficits are not well understood. The goal of this project is to better elucidate how the brain is involved in complex social interactions and the clinical relevance of these processes for personality disorders.

PI_NAMEs: GU, XIAOSI ;KOENIGSBERG, HAROLD W;SCHILLER, DANIELA  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Assertiveness;Behavioral;Belief;Borderline Personality Disorder;Brain;Characteristics;Classification;Clinical;clinically relevant;Complex;computer framework;Computer Models;Corpus striatum structure;Decision Making;Diagnosis;Diagnostic;Dimensions;Failure;Fright;Functional Magnetic Resonance Imaging;Future;geometric structure;Goals;Grain;Hippocampus;Human;Image;Impairment;indexing;Individual;Knowledge;Label;Life;Machine Learning;Measures;Mental disorders;Methods;Modeling;Nature;neural;neural circuit;neurobehavioral;neuroimaging;neuromechanism;Neurosciences Research;novel;Participant;Pathology;Patient Self-Report;Patients;Personality;Personality Disorders;Persons;Process;Property;Psychiatry;Reaction;Research;Research Domain Criteria;Resolution;Severities;Signal Transduction;social;social anxiety;Social Behavior;Social Change;Social Controls;social deficits;Social Environment;Social Interaction;social learning;social neuroscience;Social Planning;social relationships;social space;Structure;Subgroup;supervised learning;Symptoms;two-dimensional;unsupervised learning;virtual;Withdrawal;Work

PROJECT_TITLE: Neural, computational and behavioral characterization of dynamic social behavior in borderline and avoidant personality disorder


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention

ORG_CITY: EUGENE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Exercise is an important strategy to promote and maintain healthy cardiovascular, musculoskeletal, and metabolic function; however, the signals and mechanisms which transduce these effects are poorly understood. The proposed research will advance mechanistic understanding of histamine release during exercise and histamine’s involvement in adaptations to exercise. This work will lay the platform for new health interventions targeted toward at-risk populations.

PI_NAMEs: HALLIWILL, JOHN R. (contact);MINSON, CHRISTOPHER TODD

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acute;Address;Aerobic Exercise;angiogenesis;Asthma;Automobile Driving;Basic Science;Binding;Blood Vessels;Capillarity;cardiorespiratory fitness;Cardiovascular system;Cell Degranulation;Cell Physiology;Data;disorder prevention;Endothelium;Exercise;exercise capacity;exercise training;experimental study;fitness;Funding;Future;gain of function;Genes;Goals;Grant;Health;Health Benefit;Histamine;Histamine Production;Histamine Receptor;Histamine Release;Human;Hypersensitivity;improved;Inflammation;Intervention;Knowledge;loss of function;Maintenance;mast cell;Mediating;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Muscle;Musculoskeletal;novel;Oxidative Stress;Participant;Pathway interactions;Physical activity;physical inactivity;Populations at Risk;programs;prospective;Proteomics;Public Health;Reactive Oxygen Species;receptor;release factor;Research;response;Role;Series;Signal Transduction;Skeletal Muscle;Stimulation of Cell Proliferation;Temperature;tool;Training;transcriptome;Transducers;Translational Research;tumor growth;United States National Institutes of Health;Work

PROJECT_TITLE: Histamine as a Molecular Transducer of Adaptation to Exercise

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Despite many decades of research, stroke is a leading cause of mortality and long-term disability world-wide and novel therapeutic approaches are needed. Our laboratory has identified a novel pathway, active in cerebral blood vessels, the sphingosine-1-phosphate (S1P) pathway, which plays a critical role in the exacerbation of neurovascular injury in the acute phase of stroke. The proposed studies will test the hypothesis that manipulation of this pathway in the cerebral vasculature prevents neurovascular injury resulting in improved stroke outcomes.

PI_NAMEs: SANCHEZ GARCIA-VAO, TERESA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;antagonist;Anti-Inflammatory Agents;Binding Sites;Biological Assay;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;Brain;brain endothelial cell;Brain Injuries;Cerebral endothelium;Cerebral Ischemia;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Cerebrum;Data;Endothelium;Equilibrium;Functional disorder;Genetic;Genetic Transcription;Genomic Segment;Human;Human Development;improved;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Injury;Ischemia;ischemic injury;Kidney;Knockout Mice;Laboratories;Long term disability;Lung;Messenger RNA;Metabolic;Methods;Middle Cerebral Artery Occlusion;Modeling;Molecular;mortality;mRNA Precursor;Mus;neuroinflammation;Neuronal Injury;neurovascular;neurovascular injury;NF-kappaB-inducing kinase;novel;novel therapeutic intervention;Nuclear;Organ;Outcome;Pathway interactions;Permeability;Pharmaceutical Preparations;pharmacologic;Phase;PIK3CG gene;Plasma;Play;prevent;promoter;Property;Proteins;receptor;Reperfusion Injury;Research;Resources;response;rho;Rho-associated kinase;Role;Sepsis;Signal Pathway;Signal Transduction;Solubility;Specificity;Sphingolipids;sphingosine 1-phosphate;Stroke;stroke model;stroke outcome;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Transcript;Transcription Factor AP-1;translational impact;translational potential;Up-Regulation;Vascular Permeabilities

PROJECT_TITLE: Endothelial Sphingolipid Signaling in Neurovascular Ischemic Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Clinical Research;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE: ANALYTICAL VALIDATION OF FRATAXIN PROTEOFORMS IN BLOOD AS BIOMARKERS OF FRIEDREICH’S ATAXIA Friedreich’s ataxia (FA) is an autosomal recessive disease caused by an intronic GAA triplet expansion in the FXN gene, leading to reduced expression of the mitochondrial protein frataxin. We recently found that there is an extra-mitochondrial form of frataxin expressed in erythrocytes (isoform E) and that both proteoforms are reduced by > 70 % in blood from FA patients when compared with healthy control subjects. The present proposal will develop rigorously validated assays that address all of the pre-analytical and analytical issues that are relevant to the use of whole blood as a biological matrix for frataxin proteoform biomarker analysis in healthy controls, FA carriers and FA patients.

PI_NAMEs: BLAIR, IAN ALEXANDER (contact);HWANG, WEI-TING ;LYNCH, DAVID ROBINSON

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acetylation;Address;Affect;Age;Alleles;Alternative Splicing;Amino Acids;autosome;Biological;Biological Assay;Biological Markers;Blood;Blood Cells;Blood Platelets;Blood specimen;Cardiac;Cell Nucleus;Cessation of life;Clinical;Collection;Cultured Cells;Cytosol;design;Development;Disease;Erythrocytes;frataxin;Friedreich Ataxia;Genes;Half-Life;healthy volunteer;Heterozygote;High Pressure Liquid Chromatography;Immunoassay;Lateral;Length;Life;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Measurement;Methionine;Methods;Mitochondria;mitochondrial processing peptidase;Mitochondrial Proteins;Monitor;Mutation;N-terminal;nano;novel;novel therapeutic intervention;Pathology;Patients;Peptides;Plasma;Protein Isoforms;Proteins;Reaction;Resolution;sample collection;Sampling;Sensitivity and Specificity;Serum;Site;Source;Specificity;stable isotope;Testing;Therapeutic Intervention;Therapeutic Trials;therapy design;Treatment Efficacy;Triplet Multiple Birth;two-dimensional;Up-Regulation;Validation;Whole Blood

PROJECT_TITLE: Analytical validation of frataxin proteoforms in blood as biomarkers of Friedreich's ataxia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

PHR: Narrative Mycophenolic acid, an approved drug used to prevent rejection in organ transplant patients, cause chronic diarrhea that could last for years, which significantly affect patients' quality of lives. The long-term goal of this application is to develop safe and effective drugs to reduce incidence and severity of diarrhea in these patients to improve therapeutic outcomes. We propose to use dietary components that are only present in the gut to boost gut detoxification without affecting drug in the plasma to maintain therapeutic efficacy.

PI_NAMEs: GAO, SONG  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;allograft rejection;Animal Model;Antidiarrheals;Anxiety;Attenuated;attenuation;Award;Biological Availability;Caco-2 Cells;career;Cell model;Cells;Chronic diarrhea;chrysin;Clinical Research;Colon;Constipation;Detoxification Process;Diarrhea;dietary;Dietary Component;Disease;Dose;drug disposition;drug efficacy;Drug Exposure;Drug Metabolic Detoxication;drug metabolism;Drug Modelings;Drug toxicity;Drug usage;Enzymes;Epithelium;Exposure to;gastrointestinal;Gastrointestinal tract structure;Glucuronides;Glucuronosyltransferase;Goals;Gunn Rats;Hepatic;ileum;Immunosuppression;improved;In Vitro;in vivo;Incidence;innovation;intestinal epithelium;Intestines;Knowledge;Liver;Lower Gastrointestinal Tract;Mediating;Medical;Mental Depression;Metabolism;Methods;Minority Groups;Modeling;Molecular;Monitor;Morphine;mortality;multidisciplinary;mycophenolate mofetil;Mycophenolic Acid;novel;Organ;organ transplant recipient;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology and Toxicology;Phase;Plasma;prevent;Procedures;Prodrugs;Production;Protein Isoforms;psychologic;Rattus;Recycling;Regimen;Regulation;Research;residence;Role;Severities;side effect;social;SP1 gene;student training;targeted agent;Techniques;Testing;therapy outcome;Time;Tissues;Toxic effect;transcription factor;Transcriptional Regulation;Treatment Efficacy;UGT1A1 gene;UGT2B7 UDP-glucuronosyltransferase;Underrepresented Minority;wogonin

PROJECT_TITLE: Selectively Manipulating Intestinal Glucuronidation to Alleviate Mycophenolate mofetil-induced Diarrhea


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Arrhythmogenic cardiomyopathy (ACM) is a significant cause of sudden cardiac death and end stage heart failure. Disease-causing genetic abnormalities for ACM tend to cluster near each other within each gene. This study will capitalize on this recent advancement to discover novel disease-causing gene interactions, and to design a new therapy for a variety of genetic abnormalities.

PI_NAMEs: PARIKH, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adult;Arrhythmia;arrhythmogenic cardiomyopathy;Arrhythmogenic Right Ventricular Dysplasia;autosome;Binding;C-terminal;Calcium;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;Cell membrane;Cells;Cytoplasm;Data;design;Desmosomes;Disease;disease phenotype;Dominant-Negative Mutation;Engineering;engineering design;Evaluation;Exons;Failure;gene interaction;gene replacement;gene replacement therapy;Genes;Genetic;Genetic Transcription;genome editing;Genome engineering;Guide RNA;Heart failure;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;inherited cardiomyopathy;innovation;Ions;Left;Libraries;Maps;Measures;Membrane;Methods;Minority;Molecular Abnormality;Mus;Nonsense-Mediated Decay;novel;novel therapeutics;overexpression;Pathogenicity;Pathology;Patients;Phenotype;plakophilin 2;Preparation;Prevalence;prime editing;prospective;Protein Isoforms;Reagent;RNA Binding;RNA Recognition Motif;RNA Splicing;Role;single-cell RNA sequencing;Structure;sudden cardiac death;System;Techniques;Technology;Tertiary Protein Structure;theories;Therapeutic;therapeutic genome editing;Tissues;Transcript;transcriptome sequencing;Transgenic Organisms;Validation;Variant;Ventricular;Work

PROJECT_TITLE: Pathogenic hotspots illuminate mechanism and therapeutic potential in arrhythmogenic cardiomyopathy

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Lung;Lymphatic Research;Neurosciences;Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Tuberculosis infection of the central nervous system is the most devastating form of extrapulmonary tuberculosis. It is associated with a robust immune response that drives inflammation and accumulation of excess fluid (edema) in the brain. The recently re-discovered brain associated lymphatics regulate fluid drainage and immunity by controlling vessel volume and antigen trafficking to the lymph node. We have discovered that brain TB induced lymphangiogenesis and increased drainage from the brain. This proposal investigates how lymphatic regulation affects immunity and protection against TB and will test the effects of agents that increase or diminish the brain-draining lymphoid vessels on the outcome of brain tuberculosis in a murine model. This data will help broaden our understanding of the role of brain drainage in neuroinflammation using a CNS-infection model associated with different brain pathologies and may lead to new strategies in brain tuberculosis treatments.

PI_NAMEs: SANDOR, MATYAS  (contact)

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Anti-Bacterial Agents;Antibacterial Response;Antigens;Antimycobacterial Agents;Autoimmune Diseases;autoimmune inflammation;Bacterial Infections;Binding;Brain;Brain Drains;brain parenchyma;Brain Pathology;Cell Communication;Cell Physiology;Cells;Central Nervous System;Central Nervous System Infections;Central Nervous System Tuberculosis;Cerebral Edema;Cerebrospinal Fluid;Cerebrum;Cervical lymph node group;Complex;cribriform plate;Data;Dendritic Cells;Disease;disease model;Disease Outcome;Dorsal;Drainage procedure;Dura Mater;Edema;Encephalitis;Endothelial Cells;Experimental Autoimmune Encephalomyelitis;Foundations;Granuloma;Homeostasis;Human;Immune;Immune response;Immunity;Immunologic Surveillance;immunoregulation;Impaired cognition;In Situ;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Intercellular Fluid;interest;ITGAX gene;Lesion;Liquid substance;Longitudinal Studies;Lung;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic circulation;Lymphatic clearance;lymphatic drainage;Lymphatic System;lymphatic vessel;Lymphoid;Macrophage;Mediating;Meningeal;Meninges;Modeling;mortality;mouse model;Multiple Sclerosis;Mus;mycobacterial;Mycobacterium Infections;Nerve Degeneration;neuroinflammation;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Physiology;Play;Production;Proteins;Publishing;Regulation;Regulatory Pathway;Reporting;Research;Resolution;response;Role;Route;Sculpture;Severities;Source;Structure of choroid plexus;System;T-Lymphocyte;Testing;Therapeutic;Tissues;trafficking;Traumatic Brain Injury;Tuberculosis;tuberculosis treatment;Tyrosine Kinase Inhibitor;uptake;Vascular Endothelial Growth Factor Receptor-3;VEGFC gene;Waste Management;wasting

PROJECT_TITLE: The role of lymphatic clearance in brain TB

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Aging;Biotechnology;Neurosciences;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Project Narrative This proposal aims to develop novel and effective therapies utilizing a unique multipotent stem cell population to reverse age-related neuromuscular dysfunction common in the elderly, thereby improving overall health. Knowledge obtained will define the mechanism(s) by which young stem cells promote neuromuscular health and function, identify the anti-aging factors secreted by young stem cells that may be used therapeutically, and expedite effective clinical translation for rejuvenation therapies. Together these studies will significantly advance our efforts to enhance the functional abilities of older adults, leading to healthier aging and a better quality of life.

PI_NAMEs: LAVASANI, MITRA  (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;age related;age related decline;age related deterioration;aged;Aging;aging related;aging related disease;Anatomy;animal old age;anti aging;Antibodies;Area;Biological;Brain;Cell Transplantation;Cells;Cessation of life;chemokine;Chronic;circulating biomarkers;Clinical;clinical translation;clinically relevant;Critical Pathways;cytokine;Data;Defect;differential expression;Dissection;effective therapy;Elderly;Electron Microscopy;Endocrine;Environment;Exercise;exercise capacity;experimental study;fall injury;fall risk;Fiber;Fibrosis;Functional disorder;functional improvement;Gait;Growth Factor;hallmarks of aging;Health;high risk;Histology;Impairment;improved;Intervention;Knowledge;life span;light microscopy;Mammals;Measurement;Mediating;Methods;Molecular;Motor;mouse model;multipotent cell;Multipotent Stem Cells;Mus;Muscle;muscle aging;Muscle Fatigue;muscle form;muscle regeneration;muscle strength;myelination;Natural regeneration;neovascularization;Nerve Degeneration;Nerve Regeneration;Nerve Tissue;Neural Conduction;neuromuscular;Neuromuscular conditions;neuromuscular function;new therapeutic target;novel;novel strategies;novel therapeutics;old mice;older adult;Parabiosis;paracrine;Pathology;Pathway interactions;peripheral nerve regeneration;Peripheral Nerves;phosphoproteomics;Physiological;predictive marker;Process;Progeria;Proteins;Proteomics;Publishing;Quality of life;Recovery of Function;Regenerative capacity;Rejuvenation;response;restoration;Role;sarcopenia;sciatic nerve;Serum;Signal Pathway;Skeletal Muscle;skeletal muscle wasting;Specificity;Spectrum Analysis;stem cell population;stem cell therapy;Stem cell transplant;stem cells;Stimulus;Structure;System;tandem mass spectrometry;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Therapeutic Uses;Time;tissue regeneration;Tissues;Transplantation;Weight

PROJECT_TITLE: Improving Aged Neuromuscular Health and Function

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory condition that affects 10% of the United States adult population, and with serious cardiac and ischemic complications for half of these patients. Anti-hyperlipidemic therapies do not fully address the burden of ASCVD in the population. The research and training proposed in this application are relevant to public health because they increase our understanding of the cellular mechanisms associated with atherosclerosis development, progression, and potential resolution.

PI_NAMEs: MARTINEZ, LAISEL  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Acute;acute coronary syndrome;Address;Adhesions;Adult;Affect;Agonist;Agreement;Animals;Apoptotic;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;Biology;Blood Vessels;Bone Marrow Transplantation;Cardiac;career development;cell motility;Cells;Cholesterol;Chronic;Clinical;cytokine;Cytometry;Data;design;Development;Development Plans;Disease;Disease Progression;Disease regression;Doctor of Pharmacy;efficacy validation;Endothelium;Ensure;Environment;Equipment;Extravasation;Fellowship;Foam Cells;Fostering;Funding;Genetic;Goals;Human Resources;IL-13Ralpha1;Immunology;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Institution;Integrins;interest;Interleukin-13;interleukin-13 receptor;Interleukin-4;Investigation;Ischemia;Ischemic Stroke;ITGAM gene;ITGB2 gene;Journals;Knock-in;Laboratories;Leadership;Lesion;Leukocytes;lipid metabolism;Lipids;loss of function;Macrophage;Macrophage-1 Antigen;Manuscripts;Mediating;medical schools;Mentors;Mentorship;Microsurgery;Modeling;monocyte;morphometry;multidisciplinary;Mus;Myofibroblast;Necrosis;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Patients;Peptide Hydrolases;Peripheral arterial disease;Phagocytosis;Pharmacists;pharmacologic;Pharmacotherapy;Phenotype;Population;post-doctoral training;Postdoctoral Fellow;professor;Proliferating;Public Health;Publications;Publishing;Reactive Oxygen Species;receptor;recruit;Research;Research Assistant;Research Personnel;Resolution;Resource Sharing;Resources;Respiratory Burst;Rest;Role;Scientist;Signal Transduction;Site;skills;Smooth Muscle Myocytes;Specificity;Speed;Stable Disease;Surgical Models;Testing;Time;tool;Training;Training Programs;Tumor Immunity;United States;Universities;uptake;Vascular Diseases;vascular inflammation;Work

PROJECT_TITLE: Cellular Mechanisms of Mac-1 Mediated Atheroprotection


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative A subset of prostate cancers evolve in the face of therapy to look less like a typical prostate cancer and more like a small cell neuroendocrine carcinoma, as a means to bypass treatment. Here, we will integrate patient data and preclinical models to assess the molecular mechanisms driving drug resistance and determine how lineage specific transcription factors regulate cellular reprogramming and the tumor's epigenetic state to facilitate this change in identify. We will identify the context and cooperation of key drivers of disease progression and drug resistance that will lead to new strategies to improve the early detection, treatment, and mortality of patients with treatment resistant prostate cancer.

PI_NAMEs: BELTRAN, HIMISHA  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Acceleration;Adenocarcinoma;androgen independent prostate cancer;Androgen Receptor;Androgens;Area;ASCL1 gene;Automobile Driving;Biological Models;Bypass;cancer care;cancer cell;cancer initiation;Cancer Patient;cancer therapy;cancer type;Cell Reprogramming;Cell Survival;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Clinical;combinatorial;Data;data modeling;Dependence;Development;Disease;Disease Progression;DNA Methylation;DNA Sequence Alteration;Drug resistance;Drug Targeting;Early Diagnosis;effective therapy;Enhancers;Epigenetic Process;Event;Evolution;Gene Expression;Genes;Genetic Transcription;Goals;Growth;improved;Incidence;inhibitor;insulinoma associated 1;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;men;methylation pattern;Molecular;mortality;neoplastic cell;Neuroendocrine Carcinoma;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neurons;Neurosecretory Systems;Normal Cell;notch protein;Notch Signaling Pathway;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathogenesis;Pathway interactions;Patients;Phenotype;pre-clinical;Pre-Clinical Model;pressure;Process;Prognosis;programs;Prostate;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer progression;Publishing;RB1 gene;Receptor Inhibition;Receptor Signaling;Regulatory Element;Resistance;resistance mechanism;restoration;Role;Shapes;Signal Pathway;Signal Transduction;small cell lung carcinoma;Solid Neoplasm;stem;Systemic Therapy;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;TP53 gene;transcription factor;transcriptional reprogramming;tumor;Tumor Escape;tumor growth;tumor progression;Tumor Promotion;Up-Regulation;Work

PROJECT_TITLE: Molecular mechanisms underlying lineage plasticity in prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-C(02)M]


ADMINISTERING_IC: DK

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Prevention

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative This proposal addresses immune-regulatory roles of the main T cell population of the body, the intraepithelial lymphocytes (IELs), in colorectal cancer. The proposed studies will shed light on possible protective anti-tumor, as well as pro-tumorigenic roles of these mucosal immune cells against intestinal cancers, opening entirely new avenues for the design of novel immune-based therapeutic approaches against cancer.

PI_NAMEs: MUCIDA, DANIEL S (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 3-Dimensional;Address;Affect;Antitumor Response;Behavior;Cancer Model;cancer type;Carcinoma;CDX2 gene;Cell Communication;cell injury;Cells;Colitis;Colitis associated colorectal cancer;Collaborations;Colorectal Cancer;colorectal cancer prevention;colorectal cancer progression;Coupled;cytokine;cytotoxic;Data;design;Development;dextran sulfate sodium induced colitis;early onset colorectal cancer;engineered T cells;enteric infection;enteric pathogen;Epithelial Cells;Epithelium;exhaustion;experimental study;Funding;Genetic;genetic approach;genetic signature;Gnotobiotic;Human;IL17 gene;imaging approach;Immune;Immunologic Surveillance;Immunotherapeutic agent;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestinal Cancer;intestinal epithelium;Intestines;intraepithelial;Intraepithelial T-Lymphocyte;Invaded;Ions;Knock-out;Link;Literature;Location;Lymphocyte;Lymphocyte Subset;Malignant Neoplasms;Mediating;Microbe;microbial;Modeling;mouse model;Mucosal Immune System;Mucous Membrane;Mus;Mutation;Neoplasm Metastasis;novel;pathogen;Patients;Persons;Play;Population;Predisposition;prevent;Prognostic Factor;programmed cell death protein 1;Proteomics;Regulation;Research;Role;Salmonella;Stromal Cells;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Three-Dimensional Imaging;Tissues;tool;transcriptomics;tumor;tumor growth;tumor progression;tumorigenic;United States;Work;γδ T cells

PROJECT_TITLE: Intestinal surveillance by intraepithelial lymphocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(02)M]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Transgender-specific Differentiated HIV Care Models:  An Implementation Science Study PROJECT NARRATIVE Despite a disproportionate burden of HIV, transgender people are less likely to achieve viral suppression than the general population and have low engagement in PrEP services. Transgender-specific differentiated service delivery models have the potential to overcome barriers to HIV service engagement. This study will advance the science on effective HIV care and prevention strategies for transgender people by assessing the implementation, effectiveness, and cost of transgender-specific differentiated service delivery.

PI_NAMEs: IMRIE, JOHN CHISOLMGRAY;PETTIFOR, AUDREY ;POTEAT, TONIA C (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Africa South of the Sahara;AIDS prevention;arm;biobehavior;Budgets;Caring;Cities;Client;Communities;condoms;cost;cost effectiveness;cost estimate;Counseling;Data;design;Effectiveness;Enrollment;Epidemic;Evaluation;experience;gender affirmation;gender affirming care;gender affirming hormone therapy;Gender Identity;General Population;Goals;Health Policy;HIV;HIV Infections;HIV Seronegativity;hormone therapy;Human immunodeficiency virus test;implementation evaluation;implementation science;implementation strategy;implementation study;improved;Incidence;Inequity;informant;innovation;Interview;Longitudinal cohort;Lubricants;Measures;Mediating;Mediator;men who have sex with men;Methods;microcosting;Modeling;Outcome;Persons;Population;pre-exposure prophylaxis;Prevalence;prevention service;Prevention strategy;Primary Care;programs;prospective;Psychiatric Social Work;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reproductive Health;response;RNA;Science;screening;service delivery;Service delivery model;service engagement;Services;Site;social stigma;South Africa;surveillance study;Surveys;Testing;transgender;transgender men;transgender women;treatment services;Unsafe Sex;Viral;Wit;World Health Organization

PROJECT_TITLE: Transgender-Specific Differentiated HIV Care: An Implementation Science Study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Mount Sinai ADRC (Sano): OVERALL – Project Narrative The Mount Sinai Alzheimer's Disease Research Center is dedicated to “Understanding disease heterogeneity to optimize therapeutic approaches to treat and cure Alzheimer's disease”. We will partner with a diverse community to collect clinical and biological data to support multidisciplinary science with researchers at Mount Sinai and around the world to find new targets for preventing and treating Alzheimer's disease and related disorders. !

PI_NAMEs: SANO, MARY  (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Area;Autopsy;Awareness;Big Data;Big Data Methods;Biological;biological heterogeneity;Biological Markers;Biological Process;Biology;Blood;Blood Vessels;Body Fluids;Brain;Brain region;Characteristics;Clinical;Clinical Course of Disease;clinical heterogeneity;Clinical Trials Design;clinically relevant;Cognitive deficits;cohort;Collection;Communities;Complex;Computerized Medical Record;computerized tools;convict;Data;Data Science;Data Set;Data Sources;Dedications;demented;Dementia;design;Detection;Development;Discipline;Disease;disease heterogeneity;disease model;Economics;education research;Environment;Epigenetic Process;Excision;Exclusion;Exhibits;exosome;experience;Faculty;Faculty Recruitment;Failure;Fostering;Functional Imaging;Genetic;genetic analysis;genome wide association study;Genomics;Goals;Growth;Health;Heterogeneity;Human;Image;Impaired cognition;improved;Individual;induced pluripotent stem cell;Informatics;Infrastructure;innovation;Institution;institutional capacity;interdisciplinary collaboration;Knowledge;Leadership;Life;Location;Medical center;medical schools;Methods;microbiome;Mission;molecular imaging;molecular phenotype;multidisciplinary;multiple omics;Nerve Degeneration;neuropathology;new technology;Nonpharmacologic Therapy;novel;outreach;Pain;Participant;Pathogenicity;Pathology;patient engagement;Patients;pharmacologic;Phenotype;Plasma;Population;Population Heterogeneity;Preparation;prevent;Probability;Proteomics;Race;Recording of previous events;recruit;Research;research clinical testing;Research Personnel;Resources;Risk;Sampling;Science;scientific computing;Scientific Inquiry;Secure;skills;Specimen;stressor;structural imaging;success;Supercomputing;Symptoms;System;Tauopathies;Technology;Therapeutic;therapeutic development;Time;Tissues;Training;Translational Research;Traumatic Brain Injury;Underrepresented Minority;Underrepresented Populations;United States Department of Veterans Affairs

PROJECT_TITLE: Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Accountability;Action Research;Address;Administrator;Advisory Committees;Alzheimer disease prevention;Alzheimer's Disease;Animals;Applied Research;Articulation;Budgets;Calendar;cell repository;Clinical;cohort;Collaborations;Communication;Communities;comorbidity;Data;Data Collection;Dementia;Detection;Development;Diagnosis;Diagnostic;Disease;disease heterogeneity;Education;education research;Ensure;Evaluation;Event;Faculty;Faculty Recruitment;Fostering;Funding;Funding Agency;Goals;Health Insurance Portability and Accountability Act;Health system;Heterogeneity;human subject;improved;Infrastructure;Institution;International;Knowledge;knowledge of results;Leadership;Location;medical schools;meetings;Mentors;Mission;Monitor;outreach;Performance;Process;Productivity;programs;recruit;Regulation;Research;Research Personnel;resilience factor;Resource Allocation;resource guides;Resources;sample collection;Sampling;Science;Structure;success;Technology;Therapeutic;Translational Research

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE This project is designed to assist Dr. Balantekin in establishing an independent research career in the fields of obesity and disordered eating by providing training, experience, and mentorship in the areas of: 1) identifying novel treatment targets; 2) applying basic behavioral science principles towards understanding eating behavior; 3) translating lab-based studies into interventions; 4) learning novel statistical approaches for analyzing longitudinal and eating behavior data. Loss of control eating, or the feeling that one cannot control what or how much one is eating, is prevalent among children across with weight spectrum, and is associated with increased obesity risk and metabolic dysfunction. The proposed study aims to explore the relationships among LOC eating, parental restriction, and the reinforcing value of food with respect to obesity risk.

PI_NAMEs: BALANTEKIN, KATHERINE NAIME (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 10 year old;Adolescent;Applications Grants;Area;Award;Basic Behavioral Science;behavior measurement;behavioral phenotyping;Binge Eating;Body fat;bullying;Calories;Cardiovascular Diseases;career;Child;Childhood;Clinical;comorbidity;Consumption;Data;design;Desire for food;Development;Doctor of Philosophy;Eating;Eating Behavior;Eating Disorders;Energy Intake;excessive weight gain;experience;experimental study;Exposure to;feeding;Feeding behaviors;Feeling;Food;Future;Goals;Grant;indexing;Individual;instrument;Intervention;Interview;Knowledge acquisition;Laboratory Finding;Learning;longitudinal analysis;loss of control over eating;Maintenance;Medical;Mentored Research Scientist Development Award;Mentorship;Metabolic dysfunction;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;neural;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity in children;obesity prevention;obesity risk;Overweight;overweight child;Patient Self-Report;peer;Population;Prevention trial;programs;psychologic;Psychological reinforcement;Public Health;Reporting;Research;Research Activity;Research Personnel;response;reward circuitry;Rewards;Risk;Risk Factors;Role;Sampling;Scientist;social stigma;Testing;therapy development;Time;Training;Training Activity;Translating;Translational Research;Weight;Weight Gain;Work

PROJECT_TITLE: The Intersection between Loss of Control Eating and Obesity: The Role of Restriction and Food Reinforcement.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Overall Project Narrative Improving the public’s health is a significant initiative that involves a massive, complex mixture of professionals and organizations working together to achieve the mission of ensuring a healthier population. The mission can only be achieved when evidence-based information is made easily, openly, and freely available to healthcare professionals, the public health workforce, librarians, patients, researchers, educators, community-based organizations, and others dedicated to improving the health of local communities and the Nation. Region 7, through its network of partners, such as libraries, health-related institutions, and community-based organizations, provides the infrastructure, products, and services for the provision of equal access to authoritative biomedical information to those who need it, in the format they want, and at the desired time.

PI_NAMEs: PIORUN, MARY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Awareness;Collaborations;Communities;community organizations;community partners;Complex Mixtures;Data;Dedications;Diverse Workforce;effectiveness evaluation;empowerment;Ensure;Evaluation;evidence base;experience;formative assessment;Framework Regions;Future;Health;Health Personnel;Health Professional;Hospitals;Impact evaluation;improved;Information Resources;Infrastructure;Institution;Librarians;Libraries;Massachusetts;Medical Libraries;medical schools;member;Mission;Patients;Population;Positioning Attribute;programs;Public Health;Qualifying;Research;Research Personnel;Resources;Service provision;Time;Underrepresented Populations;Underserved Population;United States National Library of Medicine;Universities;vision development

PROJECT_TITLE: Regional Medical Libraries for the Network of the National Library of Medicine: Region 7 & NPHCO


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: GROSSMAN, HILLEL  (contact)

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Assessment tool;Attention;Autopsy;Biological;Biological Markers;biomarker development;Brain;Clinical;Clinical Data;clinical material;clinical phenotype;Clinical Research;clinical translation;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive testing;cohort;Collaborations;Communities;cooperative study;Cultural Diversity;Data;Data Collection;Data Set;data sharing;Dementia;design;Development;Diagnostic;Disease;disorder risk;DNA;doctoral student;Education;Elderly;Ensure;ethnic diversity;Ethnic Origin;Evaluation;follow-up;Fostering;Frequencies;Genetic;genome-wide;Genotype;Goals;Health system;Heterogeneity;high standard;Image;Imaging technology;Impaired cognition;Impairment;Individual;Industry;innovation;Institution;instrument;interest;Intervention Studies;Ligands;Methods;mild cognitive impairment;Minority Groups;Minority Participation;neuroimaging;neuropathology;Neuropsychology;normal aging;Normal Range;novel;Observational Study;Older Population;outreach;Participant;patient population;Patients;Phenotype;Physicians;Population;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;Procedures;programs;Protocols documentation;Race;Recording of previous events;recruit;Registries;Research;Research Personnel;Research Technics;resilience;Resources;Risk;Role;Rotation;Sampling;screening;Services;Side;Specific qualifier value;Specimen;Standardization;Techniques;Tissues;Training;transmission process;treatment response;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical Core


PHR: Administrative Core Project Narrative Working in collaboration with NNLM staff, Network Members, and community based- organizations, Region 7 will work to improve health literacy and access to reliable health information so that individuals have the capacity to obtain, process, and understand basic health information needed to make appropriate health decisions. This will be done by promoting the products and services of the National Library of Medicine.

PROJECT_TERMS: Awareness;Collaborations;Communication;community organizations;design;Disasters;Education and Outreach;effectiveness evaluation;Feedback;Goals;Health;health literacy;health organization;Health Personnel;Health Professional;Impact evaluation;improved;Individual;Information Networks;Leadership;Librarians;Libraries;Massachusetts;Medical Libraries;medical schools;member;operation;outreach program;Performance;Population;Process;Professional Organizations;programs;Public Health;Qualifying;Resources;Services;Structure;United States National Library of Medicine;Universities;Work

PROJECT_TITLE: Region 7 Admin-Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Rewards motivate behavior, and the prospect of reward shapes how we perform our actions. However, the mechanisms by which reward influences the fine details of our movements are not known. Experiments in this proposal will dissect the influence of reward on motor cortex in a variety of reward contexts, with the goal of determining the subconscious difference between practice and game-time, why breakdown of behavior often occurs in the face of large stakes, and the implications these processes have for learning and motor rehabilitation.

PI_NAMEs: BATISTA, AARON PAUL;CHASE, STEVEN M (contact);STAUFFER, WILLIAM RICHARD

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: addiction;Affect;Animal Model;Animals;Area;arm;arm movement;Behavior;Behavior Control;behavior influence;Behavioral;Behavioral Model;Behavioral Paradigm;Belief;Biological Models;Brain;brain computer interface;Cessation of life;Choking;Clinical;Cognitive;Coupled;Data Set;density;design;Dimensions;Disease;Dopamine;Dopamine Antagonists;dopamine system;dopaminergic neuron;Dorsal;driving behavior;Electromyography;Exhibits;experience;experimental study;fascinate;Frustration;Goals;Hand;Hemorrhage;high reward;Human;improved;Incentives;Infusion procedures;kinematics;Learning;Link;Macaca mulatta;Manufactured basketball;Mediating;Midbrain structure;Modeling;Monkeys;motivated behavior;Motivation;Motor;motor control;Motor Cortex;motor rehabilitation;Movement;Muscle;neural;neural circuit;neuromechanism;Neurons;neurophysiology;neuroregulation;neurotransmission;Noise;Outcome;Output;Parkinson Disease;Pathway interactions;Pattern;Performance;Persons;Phase;Play;Population;pressure;Process;Psychological Theory;Rehabilitation therapy;Research;response;reward anticipation;reward processing;Rewards;Role;Shapes;Signal Transduction;skills;Stroke;Structure;Subconscious;System;Testing;Time;Uncertainty;Work

PROJECT_TITLE: Neural Mechanisms of Motivated Movement


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PHR: Regional Medical Library Core Project Narrative Though community engagement, education, funding, exhibiting, and Member recruitment, Region 7 will work to promote the products and services of the National Library of Medicine and improve health literacy. Collaborating partners include the other Network of the National Library of Medicine Regions, Network Members, libraries, public health organizations, schools, and community-based organizations. Using assessment and evaluation tools, programs and services will be monitored and adjusted to maximize reach and ensure that evidence-based information is being used to improve health outcomes.

PROJECT_TERMS: Awareness;Behavior;Collaborations;Communities;community engagement;community organizations;cost;Data;data tools;digital divide;Education;Education and Outreach;Educational Curriculum;Ensure;Evaluation;evidence base;Exhibits;Funding;General Population;Health;health equity;health literacy;health organization;Health Personnel;Health Professional;Health Promotion;improved;Information Resources;interest;Leadership;Libraries;literate;Massachusetts;Medical Libraries;medical schools;member;Minority;Monitor;Outcome;outreach;prevent;Program Description;programs;Provider;Public Health;recruit;Reduce health disparities;Research;Resources;Schools;Services;System;Technology;tool;Training;Underrepresented Populations;Underserved Population;United States National Library of Medicine;Universities;Work

PROJECT_TITLE: Region 7 RML Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: ZHU, CAROLYN WEI (contact)

PROJECT_TERMS: Acceleration;Adherence;Alzheimer's Disease;Applications Grants;Area;Biological Markers;Characteristics;Clinical;Code;cohort;Collaborations;Collection;Communities;cost;Data;Data Analyses;data ecosystem;data exchange;data harmonization;data integration;data management;data resource;Data Science;data sharing;Data Sources;data standards;data submission;data warehouse;Degenerative Disorder;Dementia;disease heterogeneity;diverse data;Education;Educational workshop;electronic data;Electronic Health Record;experience;Faculty;FAIR principles;Foundations;Genomics;Goals;Health;health care service utilization;Health Services Research;Image;Informatics;Infrastructure;Link;Mentors;Methods;migration;Modernization;Neurodegenerative Disorders;neuropathology;Outcome;Paper;Patients;Policies;Process;Publications;quality assurance;Records;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;research study;resilience;Resources;Sampling;Secure;Site;Statistical Data Interpretation;Statistical Methods;statistics;success;Training;Translations;Update;web site;Work

PROJECT_TITLE: Data Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

PHR: PROJECTIVE NARRATIVE Despite the success of antiretroviral therapy (ART), HIV-1 cannot be eradicated and worldwide incidence rates have been declining slowly. Efforts to identify novel strategies to prevent new infections and eradicate or induce HIV-1 remission are critical. Broadly neutralizing antibodies (bNAbs) have emerged as an attractive new strategy against HIV-1, however bNAbs are vulnerable to escape by viral variants which underscores the need for greater understanding of the underlying mechanisms of bNAb resistance to guide the successful clinical development of this approach.

PI_NAMEs: CASKEY, MARINA  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: AIDS prevention;Animal Model;Anti-Retroviral Agents;Antibodies;Antibody Response;Antibody Therapy;antiretroviral therapy;Autologous;Cell Culture Techniques;Cell Separation;Cells;Clinical;clinical development;Clinical Research;Clinical Trials;clinically relevant;Complex;Computer Models;deep sequencing;design;Disease remission;Dose;Elements;Epitopes;Evolution;Exhibits;experience;experimental study;Genetic;Goals;HIV;HIV resistance;HIV-1;Human;Immune response;Immune system;In Vitro;Incidence;Individual;Infection;Infection prevention;Interruption;Libraries;Machine Learning;Maps;Mediating;Methods;Modality;Molecular;Molecular Conformation;mutant;Mutate;Mutation;Nature;neutralizing antibody;next generation;novel;novel strategies;novel therapeutics;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Polysaccharides;Population;Population Sizes;preclinical study;prevent;Preventive;preventive intervention;Proteins;Protocols documentation;Proviruses;Resistance;resistance mutation;resistant strain;response;Sampling;Serum;Site;success;Surface;Testing;Therapeutic;Therapeutic Intervention;V3 Loop;Variant;Viral;viral rebound;viral resistance;Viremia;Virus

PROJECT_TITLE: Defining the mechanisms of HIV resistance to bNAbs in humans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PI_NAMEs: CRARY, JOHN FONDA (contact)

PROJECT_TERMS: Address;age related;Alzheimer's Disease;Artificial Intelligence;Attention;Autopsy;biobank;Biological Markers;Biological Specimen Banks;Body Fluids;Brain;Brain region;brain research;brain tissue;chronic traumatic encephalopathy;Classification;Clinical;Collaborations;Communities;Data;data management;Dementia;Diagnostic;diagnostic platform;Education;Etiology;Evaluation;exosome;Expert Systems;Formulation;Frontotemporal Lobar Degenerations;Future;Genetic;Goals;Human;induced pluripotent stem cell;Laboratories;Lesion;Medical center;medical schools;microbiome;multiple omics;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurobiology;neuropathology;Neurosciences;Phenotype;Positioning Attribute;Preparation;preservation;Process;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Sampling;Specimen;Tauopathies;Tissues;training opportunity;Translational Research;Translations;United States Department of Veterans Affairs

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PHR: National Public Health Coordinating Office Project Narrative Public Health Departments and agencies are on the front line for delivery of basic public health services to most of the communities in this country. The majority of health departments and agencies provide a wide variety of services to very diverse communities with limited resources and staff. The services provided vary widely from state to state, from urban to rural areas, and are especially adapted to address local priorities and concerns. Despite considerable variation, however, health departments provide essential services: adult and childhood immunizations; communicable disease control; community outreach and education; epidemiology and surveillance; environmental health regulation such as food safety services and restaurant inspections; and tuberculosis testing. The NPHCO program seeks to promote the use evidence- based information and NLM resources, including the Public Health Digital Library, to strengthen the capacity for research, practice, and continuing education.

PI_NAMEs: CRESPO, JAVIER  (contact)

PROJECT_TERMS: Address;Adult;Automobile Driving;Childhood;Collaborations;Communicable Disease Control;Communication;Communities;Community Health Education;Community Outreach;Consensus;Continuing Education;Country;Digital Libraries;Education;Educational Curriculum;Environmental Health;Epidemiology;evidence base;Evidence based practice;Food Safety;Health;Health Personnel;health practice;Immunization;Information Resources;Medical Libraries;Methods;population based;Process;programs;Public Health;Public Health Education;Regulation;Research;Resources;Restaurants;rural area;Services;social health determinants;Testing;Training;Tuberculosis;United States National Library of Medicine;United States Public Health Service;Variant;Voice;Work;workforce needs

PROJECT_TITLE: NPHCO Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: SEWELL, MARGARET  (contact)

PROJECT_TERMS: Address;African American;Ally;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Autopsy;Awareness;Biological Markers;career;Caregivers;Chinese;Clinical;Clinical Research;Clinical Trials;Coffee;Cognitive;cohort;Collaborations;Communities;community advisory board;community engagement;community organizations;Community Outreach;community partners;comorbidity;Dementia;Development;Disease;doctoral student;efficacy evaluation;Elderly;Enrollment;Ethnic Origin;Event;Feedback;Fostering;Funding;Future;Genetic;Goals;Health;Health system;healthy aging;Impaired cognition;Impairment;interest;International;Interview;Investments;Knowledge;Latino;lectures;Medical Students;member;Memory;metropolitan;Middle School Student;Minority Groups;neuropathology;Newsletter;novel;Online Systems;Outcome;outreach;outreach program;Participant;Pathologic;Population;Pre-Post Tests;Prevention;Program Sustainability;programs;Questionnaires;Race;Recording of previous events;recruit;Registries;Research;Research Personnel;Research Priority;satisfaction;Series;Social Work;Social Workers;socioeconomics;Source;Spanish/English;Spirituality;success;Surveys;symposium;tool;underserved minority;Writing

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative The thymus atrophies precipitously beginning relatively early in life, resulting in declining production of new, naïve T cells, driving a shift toward an oligoclonal T cell memory, leaving the elderly less responsive to vaccines and new infections, especially viral infections. We recently showed that paracrine signaling between medullary and cortical thymic epithelial cells (TEC) involving the mammalian target of rapamycin pathway, is a key regulator of thymus growth. In this study we will generate new mTEC tissue-specific mouse models to test the hypothesis that paracrine fibroblast growth factor 21 (FGF21) signals are required for thymus growth and maintenance during aging.

PI_NAMEs: GRIFFITH, ANN VENABLES (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;adaptive immune response;Age;age related;Aging;aging population;Alleles;Antibodies;Area;Atrophic;Automobile Driving;Biology;Candidate Disease Gene;candidate identification;cell type;Cells;Cellularity;Complementary DNA;CRISPR/Cas technology;Databases;Elderly;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Exons;experimental study;fetal;FGF3 gene;fibroblast growth factor 21;Flow Cytometry;FRAP1 gene;Generations;Genes;genetic manipulation;Genetic Models;Genetic Recombination;Genetic Transcription;Growth;Growth Factor;healthspan;Immunofluorescence Microscopy;Infection;Informatics;interest;Knock-in;Knock-in Mouse;Life;life span;Maintenance;Measures;Mediating;Mediator;Memory;Modeling;Molecular;Monitor;mouse model;Mouse Strains;Mus;Natural regeneration;Newborn Infant;paracrine;Paracrine Communication;Pathway interactions;Phenotype;Phosphotransferases;Play;Population;prevent;Production;Publishing;receptor;Regulation;Reporter Genes;Research Design;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Self Tolerance;Signal Pathway;Signal Transduction;Site;Stains;Stromal Cells;Structure of thymic cortex;T cell differentiation;T memory cell;T-Cell Development;T-Lymphocyte;Tamoxifen;Testing;Thymic epithelial cell;Thymus Gland;Tissues;tool;Transgenic Organisms;Vaccines;Validation;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: The role of medullary thymic epithelial cell-derived growth factors in regulating thymus growth and atrophy

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ELAHI, FANNY M (contact)

PROJECT_TERMS: Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Autopsy;autosome;Basic Science;Biocompatible Materials;Biological Markers;Biological Specimen Banks;Blood;Blood Banks;Blood specimen;blood-based biomarker;Brain;Classification;Clinic;Clinical;Clinical Sciences;Cognitive;cohort;Collaborations;Collection;Communities;Consent;Data;Data Collection;Databases;demented;Dementia;Deposition;Disease;DNA;Dose;early onset;education research;Etiology;exome;exome sequencing;Funding;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Polymorphism;genetic risk factor;Genome;genome wide association study;Genomic approach;genomic data;Genomics;Genotype;Goals;Human Resources;Individual;Informatics;insight;International;Investigation;Laboratory Research;Longitudinal Studies;Measures;Mentorship;neuropathology;next generation sequencing;novel;novel marker;outreach;Participant;Pathogenesis;Pathologic;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Plasma;Play;programs;Proteome;Proteomics;PubMed;Quality Control;Rare Diseases;recruit;Research;Research Methodology;Research Personnel;Research Training;Resource Allocation;Risk Factors;Role;Sampling;Students;tau Proteins;Tissues;Training;Tube;Variant;whole genome

PROJECT_TITLE: Genetics and Genomics Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Ambient levels of air pollution may be an important but underappreciated contributor to racial/ethnic disparities in Alzheimer’s disease and related dementias (ADRD). Novel approaches can be applied to understand how vulnerability to air pollution in racially/ethnically diverse cohorts impact ADRD outcomes. The proposed research is critical for understanding root causes of health disparities and informing environmental policies with potential evidence-based impacts on health.

PI_NAMEs: ILANGO, SINDANA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Learning;Address;Adherence;Adverse effects;age related;Aging;Air;Air Pollution;air quality regulation;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Award;Blood Vessels;career;Caucasians;Chronic;Cognitive;Cognitive aging;cohort;Cohort Studies;Color;Communities;computerized data processing;Data;Data Sources;Dedications;dementia risk;Dimensions;Disparity;econometrics;Education;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Policy;epidemiology study;Equity;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Population;Evaluation;evidence base;Exposure to;Future;Geography;Ginkgo biloba;Goals;Health;health disparity;healthy aging;high risk;Hispanic;Housing;Impaired cognition;improved;Incidence;Individual;innovation;insight;Intervention;Latino;Latinx;Learning;low socioeconomic status;Measurement;Measures;Memory;Mentors;Methods;Mexican Americans;modifiable risk;multidisciplinary;Neighborhoods;Not Hispanic or Latino;novel strategies;older adult;Outcome;Pattern;people of color;Persons;Policies;Policy Analysis;Policy Maker;Population;Poverty;Predisposition;Public Health;Quasi-experiment;racial difference;racial disparity;racial diversity;racial minority;racial minority population;racial population;Reduce health disparities;Regulation;Research;Research Design;residential segregation;Risk;Risk Factors;risk prediction;skills;social disparities;Social Environment;social epidemiology;Structure;Testing;theories;Training

PROJECT_TITLE: The contribution of air pollution to racial and ethnic disparities in Alzheimer’s disease and related dementias: An application of causal inference methods

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: HEDDEN, JULIUS C (contact)

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Area;Autopsy;Biological;Biological Markers;blood-based biomarker;Clinical;Clinical Trials;cohort;Collection;Consult;Data;data sharing;design;Development;Disease;disease heterogeneity;disorder risk;Early Diagnosis;Enrollment;factor A;Future;Genetic;Genetic Heterogeneity;Genomics;Goals;Health Disparities Research;health disparity;Heterogeneity;Histopathology;Image;imaging biomarker;imaging facilities;improved;Individual;Informatics;innovation;Institution;Intervention;Investments;Link;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;metropolitan;mild cognitive impairment;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;New York City;open data;Participant;Pathologic;Pathology;Population;Positron-Emission Tomography;pre-clinical;Process;Recommendation;Research;Research Personnel;resilience biomarker;resilience factor;Risk Factors;Route;Sampling;Services;Sleep disturbances;Standardization;Symptoms;tau Proteins;Technical Expertise;Therapeutic Trials;Tracer;Training;Underrepresented Minority;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Biomarker Core


PI_NAMEs: ROBAKIS, NIKOLAOS K (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;Behavioral;Brain;career;career development;Clinical;Clinical Research;Clinical Sciences;Communication;Computational Science;design;Development;Development Plans;didactic education;Disease;Education;education research;Educational Curriculum;Educational workshop;effectiveness evaluation;Engineering;Ensure;Environment;Ethics;Etiology;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship;Funding;Future;Genetic;Genomics;Geriatrics;Gifts;Goals;Grant;Health;Health Services Research;improved;Individual;innovation;Instruction;Interdisciplinary Study;investigator training;K-Series Research Career Programs;Leadership;medical schools;member;Mentors;Mentorship;Methodology;Methods;multidisciplinary;Neurology;Neurosciences;novel;Outcome;Palliative Medicine;Pathology;Patients;Positioning Attribute;Postdoctoral Fellow;programs;Psychiatry;Publications;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;responsible research conduct;Science;senior faculty;Series;skills;Stress;success;Talents;Teacher Professional Development;Teaching Method;Technology;Testing;Training;translational neuroscience;Translational Research;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Research Education Component


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Fetal Tissue;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Tendon ruptures and tendinopathies are painful and debilitating conditions affecting a large portion of the adult population. From a regenerative standpoint, there is a pressing clinical need to identify the cell and molecular mechanisms regulating tendon induction and differentiation in order to develop novel therapies to improve repair outcomes. The objective of this proposal is to apply mESCs and hiPSCs to model tendon development, identify new transcriptional regulators, and induce regenerative capacity in established tendon injury models.

PI_NAMEs: HUANG, ALICE H (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: achilles tendon;Address;Adopted;Adult;Affect;Atlases;Automobile Driving;Biology;Cartilage;Cells;ChIP-seq;Chromatin;Cicatrix;Clinical;clinically relevant;Data Set;design;Development;differentiation protocol;effective therapy;Embryo;Engraftment;Enhancers;epigenetic regulation;Exhibits;experimental study;Failure;Fatty acid glycerol esters;functional restoration;Genetic Transcription;healing;Human;human induced pluripotent stem cells;Immobilization;Immune;Immune response;Immunodeficient Mouse;Impairment;improved;In Situ Hybridization;In Vitro;in vivo;induced pluripotent stem cell;Injury;knock-down;Knowledge;Label;Large-Scale Sequencing;loss of function;Macrophage;Mediating;Mesenchymal Stem Cells;Modeling;Molecular;Mouse Embryonic Stem Cells;multiple omics;Multipotent Stem Cells;Mus;mutant;Myofibroblast;Natural regeneration;novel;novel therapeutics;Outcome;Pain;paracrine;Pathologic;Phenotype;Population;prevent;progenitor;recruit;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regenerative pathway;Regulation;repaired;single-cell RNA sequencing;small hairpin RNA;Source;Standard Model;stem;stem cells;Structure;Tendinopathy;tendon development;Tendon Injuries;tendon rupture;Tendon structure;Testing;Therapeutic;Time;transcription factor;Transcriptional Regulation;translational potential

PROJECT_TITLE: Regulation of human tendon development and regeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Aging;Neurosciences;Obesity;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE STATEMENT Aging increases bone loss, fractures, disability, and frailty. Aging process is linked with increasing inflammation which if not resolved, causes progressive decline of skeletal function. This project studies the underlying mechanism that causes loss of bone function by studying specialized cells that can produce inflammation due to progressive accumulation of fat within bone.

PI_NAMEs: DIXIT, VISHWA DEEP (contact)

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Age;age related;age related changes;Aging;aging process;aging related disease;Biological Availability;Body System;bone;bone health;bone loss;Bone Marrow;bone strength;Catecholamines;Cells;Chronic;Chronic Disease;cortical bone;Coupled;cytokine;Data;disability;Down-Regulation;Elderly;Enzymes;Event;Fatty acid glycerol esters;fatty acid oxidation;Fracture;frailty;Generations;Goals;hallmarks of aging;healthspan;Hematopoiesis;Hematopoietic Stem Cell Transplantation;human model;Hydrolysis;Immune;immune reconstitution;Immune system;Impairment;improved;Inflammaging;Inflammasome;Inflammation;Knock-in;Knockout Mice;Link;Lipids;Lipolysis;LoxP-flanked allele;Macrophage;Marrow;mass spectrometric imaging;Mediating;Membrane;Metabolic;Metabolic dysfunction;Monoamine Oxidase A;mouse model;Mus;Myeloid Cells;Nerve;Nerve Degeneration;nerve supply;Neuroimmune;Norepinephrine;novel strategies;Obesity;old mice;Organ;Osteitis;Osteoclasts;Osteoporosis;Post-Translational Regulation;postsynaptic;prevent;primary lymphoid organ;Process;protein expression;Radiation;regenerative;Regulation;Research;skeletal;stem cell engraftment;substantia spongiosa;success;Sympathetic Nervous System;Synaptic Vesicles;Testing;Thymus Gland;Time;Tissues;Transcriptional Activation;Transcriptional Regulation;Transgenic Mice;Triglycerides;Tyrosine 3-Monooxygenase

PROJECT_TITLE: Immunometabolic regulation of bone inflammaging


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Protein synthesis is important for cell viability and is subjected to multiple regulatory mechanisms. Our preliminary data show that the intracellular bacterium Legionella pneumophila induces global protein synthesis inhibition by phosphorylating a single residue in the chaperone HSC70 (pHSC70). Here we propose to understand the mechanisms by which this phosphorylation affects protein synthesis and the host stress response pathways that can lead to pHSC70 and protein synthesis inhibition.

PI_NAMEs: MUKHERJEE, SHAERI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Adopted;Affect;Alkylating Agents;ATP phosphohydrolase;Attenuated;attenuation;Bacteria;Bacterial Proteins;Binding;Biochemical;biological adaptation to stress;Biological Assay;Cell Death;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Co-Immunoprecipitations;Collaborations;Cytosol;Data;DNA Damage;DNA-dependent protein kinase;Eukaryotic Initiation Factor-2;Event;experimental study;Fluorescence;Goals;Guanine Nucleotide Exchange Factors;Heat-Shock Proteins 70;Heat-Shock Response;In Vitro;in vitro activity;in vivo;Ionizing radiation;Legionella pneumophila;Life;Link;Mass Spectrum Analysis;Mediating;member;Methyl Methanesulfonate;mimetics;Molecular;Molecular Chaperones;Molecular Conformation;mRNA Translation;mTOR inhibition;mutant;novel;nucleocytoplasmic transport;Nucleotides;overexpression;pathogen;pathogenic bacteria;Pathway interactions;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physiologic pulse;Play;polypeptide;Polyribosomes;Process;Protein Biosynthesis;protein folding;protein function;protein purification;Protein Secretion;Protein Synthesis Inhibition;Protein-Serine-Threonine Kinases;Proteins;Proteolysis;proteostasis;proteotoxicity;Publishing;Recombinants;reconstitution;Regulation;Research Personnel;response;ribosome profiling;Ribosomes;Role;Signal Transduction;Site;spatiotemporal;Stress;stressor;Testing;tool;Topoisomerase II inhibition;Transcript;Translating;Translational Repression;Translations;UV Radiation Exposure;Work

PROJECT_TITLE: Role of HSC70 in protein synthesis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: KENT

ORG_DEPT: BIOLOGY

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Circadian timing of the preovulatory surge in GnRH and LH secretion is critical in regulating ovulation and reproductive success in rodents as well as, possibly, in women. This proposal will provide new knowledge of the neural circuits that govern the circadian activation of kisspeptin neurons – a cell population essential for the preovulatory surge under physiological conditions. This research, when completed, may provide the foundation for future opportunities in treating ovulatory dysfunction.

PI_NAMEs: PIET, RICHARD  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Action Potentials;Address;Anatomy;Area;Argipressin;argipressin receptor;Automobile Driving;Axon;Behavior;Brain;Cell Nucleus;Cells;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Cues;Data;Diurnal Rhythm;Electrophysiology (science);Ensure;Equilibrium;ESR1 gene;Estrogens;Estrous Cycle;Event;Exhibits;Female;Fertility;Foundations;Future;gamma-Aminobutyric Acid;GNRH1 gene;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Hormone secretion;Hour;Human;Hypothalamic structure;Immunohistochemistry;KISS1 gene;Knowledge;Luteinizing Hormone;Mediating;neural circuit;neuromechanism;neuronal circuitry;Neurons;Neuropeptides;Neurosecretory Systems;neurotransmission;optogenetics;Output;ovarian dysfunction;Ovariectomy;Ovulation;Pattern;Physiological;Physiology;Play;Population;Preoptic Areas;Preparation;presynaptic;Proestrus;Publishing;Receptor Signaling;Regulation;Reporting;Reproduction;reproductive success;Research;response;Rodent;Role;Sex Behavior;Signal Transduction;Slice;suprachiasmatic nucleus;Synapses;Testing;Third ventricle structure;Time;Ventricular;Woman;Work

PROJECT_TITLE: Suprachiasmatic nucleus to kisspeptin circuit in the circadian control of reproduction

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Arrhythmogenic Cardiomyopathy (ACM) is a familial disease characterized by early-onset ventricular arrhythmias arising in the absence of overt cardiac remodeling, with subsequent development and progression of heart failure. This application focuses on the critical interactions between external factors imposed by exercise and genetic factors caused by mutations in the intercalated disc protein desmoplakin. We will develop next generation therapies for ACM that target the abnormal signaling cascade that the interaction between exercise and DSP haploinsufficiency unleashes.

PI_NAMEs: AKAR, FADI GABRIEL;CAMPBELL, STUART G (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adrenergic Agents;Age Years;Arrhythmia;arrhythmogenic cardiomyopathy;autosome;Bioreactors;Calpain;calpain inhibitor;calpastatin;Cardiac;cardiac tissue engineering;Cardiomyopathies;Cell Line;Chronic;Clinical;Complex;desmoplakin;Desmosomes;Development;Disease;Disease Progression;disease-causing mutation;early onset;Echocardiography;Electrocardiogram;endurance exercise;Event;Exercise;Exhibits;experience;experimental study;Failure;Familial disease;Female;Fibrosis;Frequencies;Functional disorder;gene environment interaction;Generations;Genes;Genetic;Genetic Predisposition to Disease;Heart failure;Heart Rate;Heritability;Heterozygote;Human Engineering;In Vitro;in vivo;Incidence;indexing;Individual;Infiltration;Inflammation;Inherited;innovation;Intercalated disc;Intervention;Intraperitoneal Injections;Ion Channel;Knock-in;Left;Link;Maintenance;male;Maps;Measures;Mechanics;mechanotransduction;Mediating;microCT;mitochondrial dysfunction;model design;Molecular;mouse model;Mus;Muscle Cells;Mutation;Myocardial dysfunction;next generation;novel;Operative Surgical Procedures;Optics;overexpression;Pathogenicity;Patients;Pattern;Penetrance;pharmacologic;Phase;Prevention strategy;Production;Proteins;Proteolysis;Reactive Inhibition;Reactive Oxygen Species;Risk;Secondary to;Shunt Device;Signal Transduction;small molecule;Stress;stressor;Stretching;sudden cardiac death;Symptoms;Syndrome;Telemetry;Testing;Therapeutic;Therapeutic Effect;Time;Toxic effect;transmission process;Variant;Ventricular;Ventricular Arrhythmia;Work;X-Ray Computed Tomography

PROJECT_TITLE: Desmoplakinopathies: Integrated Pathophysiology and Therapeutics

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Aggressive behavior in pituitary tumors is defined by rapid growth following standard treatment (surgery and radiation); at present, there are no biomarkers that reliably predict future aggressive behavior. We aim to identify these biomarkers by performing genetic and epigenic profiling on a unique cohort that includes patients with malignant tumors. The ability to identify patients with life-limiting tumors at an earlier stage would improve patient outcomes.

PI_NAMEs: LIN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;adenoma;Aggressive behavior;Algorithms;Alkylating Antineoplastic Agents;Anterior Pituitary Gland;Askenazy Cells;Autopsy;Behavior;Benign;Biological Markers;biomarker validation;Blindness;Brain;Brain Neoplasms;Characteristics;Chromosomal Loss;Chromosomes;Clinical;clinical decision-making;clinical phenotype;Clinical Trials;clinically relevant;Clonality;cohort;Communities;Consent;Copy Number Polymorphism;Data;Data Set;density;Development;Diagnosis;Disease;Disease Progression;DNA methylation profiling;Endocrinologist;Epigenetic Process;Excision;Exhibits;exome sequencing;follow-up;Future;Genes;Genetic;Genome;Genomics;Goals;Growth;high risk;hormone therapy;improved;Incidence;Individual;Indolent;Institution;Intracranial Neoplasms;Invaded;Islet Cell Tumor;lactotroph;Life;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;men;Methylation;Molecular;molecular marker;molecular subtypes;Morbidity - disease rate;mortality;Mutation;National Cancer Institute;Natural History;Neoplasm Metastasis;Neuroendocrine Tumors;Neurologic Dysfunctions;next generation sequencing;Noise;novel therapeutics;Operative Surgical Procedures;Oral;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Pituitary carcinoma;Pituitary Corticotropin Secreting Adenoma;Pituitary Gland Adenoma;Pituitary Neoplasms;predictive marker;Prevalence;prevent;prospective;Radiation;Radiation therapy;rapid growth;Recurrence;Registries;Reporting;response;Sampling;SEER Program;skull base;standard care;standard of care;Subgroup;temozolomide;Time;tumor;Tumor Bank;tumor registry;United States;Validation;Work;World Health Organization

PROJECT_TITLE: Molecular biomarkers of future aggressive behavior in pituitary tumors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Rehabilitation

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Older adults decide to have major elective surgery hoping for improved function or longer life, but some will experience a long-term decline in cognition after surgery. This study will use two large, diverse databases of older adults to create and test a mathematical model predicting whether an individual is likely to be at risk of memory decline, dementia, and/or loss of function (ability to manage medicines and money independently) two years after major surgery. Accurate, individualized predictions for patient-centered cognitive outcomes will help clinicians and older adults talk about what to expect after surgery and ensure that choosing to have elective surgery meets older adults’ goals for cognitive health in late life.

PI_NAMEs: WHITLOCK, ELIZABETH LOUISA (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Accounting;Adult;Adverse event;adverse outcome;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Benefits and Risks;billing data;Calibration;Caring;Clinical;clinical predictive model;clinically relevant;clinically significant;Cognition;Cognitive;cohort;Collaborations;Critical Pathways;Data;Data Sources;Databases;Decision Making;Delirium;Dementia;dementia risk;design;Discrimination;Economics;Ensure;Equilibrium;Ethics;Event;experience;functional decline;Functional disorder;functional improvement;Future;Goals;Health;Health and Retirement Study;health data;health goals;Heterogeneity;High Prevalence;hospital readmission;human old age (65+);Impaired cognition;improved;Individual;Informed Consent;Inpatients;instrumental activity of daily living;late life;Life;Link;long term memory;loss of function;mathematical model;Measurement;Medicare;Medication Management;Medicine;Memory;Memory Loss;Methodology;Methods;model generalizability;Modeling;neurocognitive disorder;older adult;older patient;Operative Surgical Procedures;Outcome;Pain;patient oriented;Patients;Performance;personalized predictions;Persons;Pharmaceutical Preparations;Physicians;Population;Population Heterogeneity;postoperative delirium;Postoperative Period;predictive modeling;Prognosis;Proxy;Publishing;Quality of life;Research;Rest;Risk;Sample Size;Shapes;shared decision making;Study models;surgery outcome;surgical risk;Testing;Time;trend;United States;Validation;Work

PROJECT_TITLE: Predicting long-term cognitive outcomes and Alzheimer’s disease and related dementias after major noncardiac surgery for older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: To enhance understanding the microbiome's dynamic role in disease progression, and explore its clinical potential, we will develop two sets of analytic methods designed to 1) detect genome-wide microbial variants, identify strains within species, and estimate strain relative abundance using longitudinal metagenomics samples and 2) develop, validate, and apply the microbial risk scores in disease prediction. Further, we will validate the proposed tools in multiple longitudinal microbiome studies; explore new insights; and develop, distribute, and support open-source software packages to apply the tools.

PI_NAMEs: LI, HUILIN  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Address;Affect;analytical method;analytical tool;bacterial community;Bioconductor;Bioinformatics;bioinformatics tool;Cardiovascular Diseases;Cessation of life;Characteristics;Clinical;Code;cohort;Collaborations;Communities;Companions;Complex;Computer software;Computing Methodologies;COVID-19;COVID-19 patient;Critical Illness;Data;Data Analyses;design;Diabetes Mellitus;Disease;Disease Progression;disorder risk;Ecosystem;Environmental Exposure;experience;Future;Galaxy;gene function;Genes;Genetic;Genetic Models;genetic variant;Genetic Variation;genome-wide;Growth;Health;High-Throughput Nucleotide Sequencing;holistic approach;Human;Human Characteristics;Human Microbiome;human microbiota;improved;Infant;Inflammatory Bowel Diseases;innovation;insight;Link;Longitudinal Studies;Malignant Neoplasms;Mechanical ventilation;Mediating;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microbiome analysis;microbiome research;microbiome signature;multidisciplinary;Nature;New York;novel;novel strategies;novel therapeutics;Obesity;open source;Organ;Outcome;Pathway interactions;Performance;Phenotype;Phylogenetic Analysis;population based;Population Genetics;prevent;Process;Property;repository;Research Design;Research Methodology;Research Personnel;respiratory microbiome;Risk;risk prediction;Role;Sampling;Scheme;software development;Source;Statistical Models;Structure;System;Systems Analysis;Taxonomy;Techniques;Technology;Time;tool;trait;Trees;Universities;Variant;web based interface;Work

PROJECT_TITLE: Novel Computational Methods for Microbiome Data Analysis in Longitudinal Study

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Neutrophils are the first line of defense against infection and exhibit a unique cell-killing mechanism called trogoptosis (“gnawing”), based on successive puncturing of cancer cell membranes. We investigate the efficacy of this mechanism in the context of different tumor cell surface markers as well as the extracellular matrix. We envision that neutrophil trogoptosis can be therapeutically enhanced for anti-tumor activity in combination with adjuvant drug therapy.

PI_NAMEs: REICHNER, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Adhesions;Adjuvant;Adjuvant Chemotherapy;Agonist;anti-cancer;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;Antitumor Response;Apoptosis;Biomimetics;Breast Cancer Cell;Breast Cancer Patient;Budgets;cancer cell;cancer immunotherapy;CD18 Antigens;cell killing;Cell membrane;Cell surface;Cells;Cellular Spheroids;Cessation of life;Clinic;Clinical;clinically relevant;Collaborations;Complement;cytotoxic;Cytotoxic T-Lymphocytes;Data;Disease;druggable target;Effectiveness;Effector Cell;efficacy evaluation;Elasticity;Epidermal Growth Factor Receptor;Exhibits;experimental study;Extracellular Matrix;Family;Fibroblasts;Fibroins;Gel;Genetic;Greek;Host Defense;Human;Immune;Immune response;Immunotherapy;Infection;insight;Integrins;interest;Invaded;ITGAM gene;ITGB2 gene;Laboratories;Learning;Lectin;live cell imaging;Macrophage;Macrophage-1 Antigen;Malignant Breast Neoplasm;Malignant Neoplasms;MDA MB 231;Mediating;Medical;migration;Modeling;Natural Killer Cells;Necrosis;neoplastic cell;neutrophil;Neutrophil Infiltration;Organ;Organ failure;Phagocytosis;physical property;Physiological;Protocols documentation;Psychological reinforcement;Publishing;Puncture procedure;receptor;Regulatory Element;Sepsis;Silk;Site;spheroids;Structure;Synapses;System;Testing;Therapeutic;three dimensional cell culture;Tissues;triple-negative invasive breast carcinoma;tumor;Tumor Antibodies;tumor progression;Work

PROJECT_TITLE: Investigating the Ability of Human Blood Neutrophils to Kill Cancer


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Prevention

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Half of patients with heart failure have preserved heart pumping function, with limited tools to prevent, diagnose, and treat this condition. The body’s response to the stress of exercise may uncover abnormalities not apparent at rest that can help to diagnose heart failure with preserved ejection fraction before the onset of symptoms. Here, we measure a large number of proteins in the blood and compare them with patterns of a person’s response to exercise to better understand this disease, its earlier forms, and potential treatments.

PI_NAMEs: LEWIS, GREGORY DYER;NAYOR, MATTHEW G. (contact);SHAH, RAVI

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Acute;assay development;biobank;Biochemical;Bioinformatics;Biological;Biological Markers;Blood;Blood specimen;Blood Vessels;Body mass index;Body System;Cardiac;cardiometabolism;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;Cells;Clinical;clinical development;clinical heterogeneity;cohort;Collection;Communities;cost;cost effective;Data;Databases;Detection;Development;Diagnosis;Disease;EFRAC;Epidemiology;Exercise;Exercise Test;Exposure to;Fibrosis;fitness;Framingham Heart Study;Functional disorder;Genetic;Grant;Heart failure;heart preservation;hemodynamics;Heterogeneity;Human Genetics;impaired capacity;Impairment;improved;in silico;Individual;innovation;instrument;Kinetics;lifestyle factors;Link;Lung;Measures;Mendelian randomization;Metabolic;metabolomics;Methods;Molecular;Natural Immunity;novel;Obesity;Organ;Oxygen;Participant;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;Phenotype;Physical activity;Physiological;Physiology;Plasma;Predisposition;Preparation;preservation;prevent;Prevention;Primary Prevention;Process;Production;Prognosis;prospective;Proteins;Proteome;proteomic signature;Proteomics;Pump;racial diversity;Reporting;Resources;response;Rest;Risk;Risk Factors;Sampling;screening;sedentary;Site;Skeletal Muscle;Specific qualifier value;stomach cardia;Stress;Symptoms;Time;Tissues;tool;United States National Institutes of Health;uptake;Validation;Work

PROJECT_TITLE: Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biotechnology;Osteoarthritis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative Osteochondral tissue injuries remain a significant challenge in the orthopedics community, as they affect millions of people each year throughout the world and there are few viable treatment options. We propose to engineer prevascularized osteochondral tissue constructs using direct assembly of individual human mesenchymal stem cells (hMSCs) and human endothelial progenitor cells (hEPCs) via 3D bioprinting into a temporary photocurable microgel slurry supporting medium with spatiotemporally controlled delivery of tissue-specific growth factors. This new strategy to create functional osteochondral tissue through printing of a carrier-free cell-only bioink to form complex cellular condensations may represent a powerful clinical therapeutic advance to treat and improve the lives of patients suffering from osteochondral tissue damage.

PI_NAMEs: ALSBERG, EBEN  (contact);JEON, OJU

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Affect;Alginates;Architecture;Bathing;bioink;Biomimetics;bioprinting;bioscaffold;Blood Vessels;bone;bone repair;Cartilage;cartilage repair;cartilaginous;Cell Communication;Cells;Chemicals;Clinical;Communities;Complex;Defect;Degenerative polyarthritis;design;Endothelial Cells;endothelial stem cell;Engineering;Evaluation;Face;Fibrocartilages;Functional Regeneration;Gel;Geometry;Growth Factor;healing;Health;Human;human stem cells;Hydrogels;Immune;improved;in vivo;Individual;Inferior;Inflammatory;innovation;Knee;Liquid substance;Location;Maintenance;Mechanics;Mesenchymal Stem Cells;Modeling;Modification;Movement;novel;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;osteochondral tissue;osteogenic;particle;Patients;Persons;Phase;Phenotype;Physical condensation;physical property;Positioning Attribute;Printing;Procedures;Property;Reaction;repaired;Research Personnel;Resolution;Role;scaffold;Shapes;Solid;spatiotemporal;standard of care;stem cells;Structure;Techniques;Technology;Therapeutic;Thick;Thinness;three dimensional structure;Tissue constructs;Tissue Engineering;tissue injury;tissue regeneration;Tissues;Vascularization;Vasculogenic

PROJECT_TITLE: Individual cell bioprinting to generate multi-tissue type condensations for osteochondral tissue regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]