NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_STATE: CA

PHR: Project Narrative There is an urgent need to better understand the geospatial and temporal dimensions of human mobility that lead to disparities in HIV outcomes, and for feasible and scalable interventions to improve HIV outcomes in mobile populations. Yet, research in these areas is nascent, and there is a great need for an expanded scientific workforce with training in human mobility and HIV to tackle these challenges. This application for the Midcareer Investigator Award in Patient-Oriented Research (K24) proposes a comprehensive mentoring, research and career development plan which will lay the groundwork for sustained, high impact research that is urgently needed to address the challenges posed by mobility to achieving HIV prevention and treatment goals.

PI_NAMEs: CAMLIN, CAROL SUZANNE (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;AIDS prevention;Area;Automobile Driving;Behavioral;Budgets;California;care outcomes;career;career development;Caring;Clinic;Clinical Investigator;Clinical Trials;Cohort Studies;Communities;Complex;cost;Data;Demography;design;Destinations;Development;Development Plans;Dimensions;Discipline of obstetrics;Disparity;Eastern Africa;Elements;Epidemic;Exposure to;Faculty;feasibility testing;Funding;Funding Mechanisms;Geographic Locations;geographic population;Geography;Goals;Gynecology;Health system;HIV;HIV risk;HIV/STD;Human;implementation framework;improved;Infrastructure;Intervention;Intervention Studies;Interview;Kenya;Knowledge;Lead;Link;Location;Longitudinal Studies;Measurement;Measures;Medicine;meetings;men;Mentors;Mentorship;Methods;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Modeling;multidisciplinary;network models;novel;Outcome;Pathway Analysis;patient oriented research;Patients;Persons;Pilot Projects;Play;Population;population based;preference;Prevalence;programs;prototype;Provider;Public Domains;Reproductive Sciences;Research;research and development;research study;Resources;Role;San Francisco;Scientist;Sex Behavior;social;Social Network;social network intervention;Sorting;Testing;Theoretical Domains framework;Theoretical model;theories;therapy development;Time;Training;transmission process;Treatment outcome;Uganda;Universities;Woman;Work

PROJECT_TITLE: Mentoring Clinical Investigators in Patient Oriented Research on Human Mobility and HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);HIV/AIDS;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE This program trains post-doctoral fellows in clinical research to more effectively understand and manage the challenges of HIV and other infectious consequences of substance use. Incorporating expertise from multiple disciplines greatly enhances diagnosis, prevention and treatment research of HIV and other infectious diseases among people who use drugs and within communities that are heavily impacted by the substance use and overdose epidemics. Community engagement is emphasized to ensure that marginalized communities benefit from advances in biomedical science.

PI_NAMEs: GREEN, TRACI C;RICH, JOSIAH D (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: HIV;substance use

PROJECT_TITLE: HIV and Other Infectious Consequences of Substance Use


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Motivational interviewing (MI) is a leading evidence-based practice (EBP) for substance use disorder, but MI use and fidelity have been low in usual care. Strategies have been developed to support program leaders in improving EBP implementation climate, but it is not yet known whether these strategies work by improving alignment in perceived implementation climate between providers and leaders. The proposed project will leverage data from a cluster randomized trial of an organizational implementation strategy (LOCI) to: (1) measure vertical alignment of perceived implementation climate, (2) identify organizational factors associated with alignment, and (3) examine sensitivity to change, and explore associations with exposure to LOCI and provider MI implementation outcomes.

PI_NAMEs: BYEON, YOUNG VIVIAN (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: addiction;Adolescent;Adult;Affect;Agreement;Behavior;behavioral health;career;Characteristics;Client;Climate;Clinic;Cluster randomized trial;Communities;contextual factors;Data;Development;evidence base;Evidence based practice;Exhibits;experience;Exposure to;Fostering;Frontline worker;Funding;Growth;Health Services;implementation context;implementation facilitation;implementation outcomes;implementation strategy;improved;indexing;Individual;Intervention;Leadership;Link;Measurement;Measures;member;Mentors;Modeling;motivational enhancement therapy;National Institute of Drug Abuse;National Research Service Awards;novel;Organizational Change;organizational climate;Organizational Policy;Outcome;Patient-Focused Outcomes;Patients;Perception;Policies;population health;Procedures;Process;programs;Provider;Public Health;reduced substance use;Research;Research Priority;Scientist;Service setting;Signal Transduction;Strategic Planning;Structure;substance abuse treatment;Substance Use Disorder;Testing;theories;Time;Training;treatment as usual;treatment program;uptake;Variant;Work

PROJECT_TITLE: Examining vertical alignment in perceived implementation climate within a trial of motivational interviewing in substance use disorder treatment clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project aims to investigate the mechanisms of in utero exposure to alcohol on mammary tumor development in MMTV-erbB2 transgenic mice. We will focus on in utero exposure to alcohol-induced estrogen receptor-erbB2 crosstalk in signal transduction and mammary stem cell reprogramming. The results from this project will have a profound impact on our understanding of the mechanisms that contribute to in utero exposure to alcohol- associated breast cancer risk later in life.

PI_NAMEs: YANG, XIAOHE  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;alcohol consumption during pregnancy;alcohol exposure;Alcohols;aldehyde dehydrogenase 1;Biological Models;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Etiology;cancer prevention;cancer stem cell;Carcinogens;career;Cell Differentiation process;Cell Reprogramming;Cells;Cellular Assay;clinically relevant;Data;density;Development;Diet;disorder risk;Dose;Environmental Risk Factor;Epithelium;erbB-2 Receptor;ERBB2 gene;ERBB2 Signaling Pathway;ESR1 gene;Estrogen Receptors;estrogenic;Etiology;Exposure to;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fetal Diseases;Future;Gene Expression;Gene Expression Microarray Analysis;Gene Expression Profile;Genetic Predisposition to Disease;Goals;Growth;Health;High Risk Woman;Human;indexing;Individual;innovation;insight;ITGB3 gene;Life;Link;Liquid substance;Malignant - descriptor;Malignant Breast Neoplasm;mammary;Mammary Duct;Mammary gland;Mammary Neoplasms;Mammospheres;maternal alcohol use;Microarray Analysis;minority student;Modeling;Molecular;Molecular Profiling;Mouse Mammary Tumor Virus;mouse model;Mus;Myoepithelial;novel;novel strategies;Paper;Pathway interactions;Pregnancy;premalignant;prenatal exposure;Prevention strategy;promoter;Puberty;Publishing;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Reporting;research clinical testing;response;Risk;Role;Series;Signal Pathway;Signal Transduction;Sorting;stem cell biomarkers;Stem cell transplant;stem cells;stemness;tissue stem cells;Tissues;TNFSF11 gene;Transforming Growth Factor beta;Transgenic Mice;tumor;tumor initiation;undergraduate research experience;Up-Regulation;Woman;young adult

PROJECT_TITLE: In utero exposure to alcohol-induced mammary stem cell deregulation and tumor risk later in life.


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Human neurological diseases associated with monoaminergic (e.g., serotonin, norepinephrine, dopamine) dysfunction affect millions of individuals worldwide; however, treatments for these neurodevelopmental, neurodegenerative and/or psychiatric disorders remain inadequate. Here, employing a truly unique combination of biochemical, molecular, and behavioral approaches, we are examining novel, neurotransmission independent roles for serotonin in brain in the direct regulation of neuronal gene expression. The experiments in this proposal will leverage cutting-edge technologies to understand how alterations in histone serotonylation (i.e., the covalent addition of serotonin to histone proteins) directly modulate neurodevelopmental and early life neural plasticity.

PI_NAMEs: CUNNINGHAM, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Architecture;Attenuated;Beds;Behavior;Behavioral;behavioral phenotyping;Biochemical;Brain;brain circuitry;brain control;Brain region;Cell Nucleus;Cell Separation;cell type;Chronic stress;Cleavage Under Targets and Release Using Nuclease;combinatorial;covalent bond;critical period;Data;Development;Dopamine;Dorsal;early life stress;Embryo;Embryonic Development;Environmental Impact;epigenetic regulation;epigenomics;experimental study;Exposure to;extracellular;Female;Foundations;Functional disorder;Gene Expression;Gene Expression Regulation;gene-editing approach;Genes;Genetic Transcription;genomic locus;Genomics;Glutamine;Histone H3;histone modification;Histones;Homeostasis;Hormones;Human;Image;imaging approach;Imaging Techniques;in vivo;Individual;insight;Laboratories;Life;lifetime risk;Ligands;Lysine;male;maternal separation;Mediating;medical schools;Mental Depression;Mental disorders;Mentorship;Methylation;Modeling;Modification;Molecular;monoamine;mood regulation;multiple omics;Mus;Neonatal;nerve supply;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neuronal Plasticity;Neurons;neuropsychiatry;neurotransmission;Neurotransmitters;Norepinephrine;novel;Nuclear;Pattern;permissiveness;Play;Population;Post-Translational Protein Processing;postnatal;postnatal development;postnatal period;pre-clinical;preclinical study;Predisposition;Prefrontal Cortex;Process;Prosencephalon;Proteins;receptor;Regulation;response;Risk Factors;Rodent Model;Role;Serotonin;sex;Sex Differences;Stimulus;Stress;stress reactivity;Synapses;System;Techniques;Technology;Therapeutic;Time;transcription factor;transcriptome sequencing;transcriptomics;Viral;Viral Vector

PROJECT_TITLE: Functional Role for H3 Serotonylation During Critical Periods of Postnatal Brain Development and Plasticity


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Prevention

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative / Relevance Our proposed research is aimed at developing chemical probes and molecules that can measure and affect the biological activity of enzymes that repair damage in DNA. We will use our new compounds to test our hypotheses regarding how these enzymes might be targeted to prevent cancer in people who have a high risk of acquiring the disease. This work will provide valuable tools for cancer researchers, and may result in new and more effective strategies for cancer prevention and treatment.

PI_NAMEs: KOOL, ERIC T. (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Address;adverse outcome;Affect;Animal Disease Models;anti-cancer research;Assessment tool;Basic Science;Biological;Biological Assay;Biological Models;Biological Testing;brca gene;cancer drug resistance;Cancer Etiology;Cancer Patient;cancer prevention;cancer therapy;Cell Culture Techniques;Cell Line;Cell model;Cells;Cessation of life;Chemicals;Chemoprevention;Clinical;Clinical Research;clinically relevant;Colorectal Cancer;Communities;Cytosine;Deamination;Development;Diagnosis;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;DNA Sequence Alteration;Drug resistance;enzyme activity;Enzymes;experience;Genes;Genetic Predisposition to Disease;Growth;Heart;high risk;High-Risk Cancer;Image;Incidence;Inflammation;Inflammatory;innovation;Intestines;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Molecular;Molecular Target;mouse model;Mus;Mutagenesis;Mutation;Neoplasm Metastasis;novel;OGG1 gene;Outcome;oxidative damage;Pathway interactions;Patients;Persons;Point Mutation;polyposis;Population;Populations at Risk;precision medicine;prevent;Prevention;Prevention strategy;repair enzyme;repaired;Reporter;Research;Research Personnel;Risk;small molecule;Solid Neoplasm;Source;Specimen;Syndrome;Testing;Tissues;tool;tumor;tumorigenesis;whole genome;Work

PROJECT_TITLE: Measuring and Modulating DNA Damage Surveillance Pathways

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Project Narrative We propose to develop new platforms to genetically encode many previously inaccessible noncanonical amino acids to model novel protein post-translational modifications in eukaryotic cells. These optimized tools would be used to systematically probe how post-translational modifications modulate the biology of eukaryotic cells.

PI_NAMEs: CHATTERJEE, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Amino Acids;Anabolism;Biochemical;Biology;Catalogs;Chemicals;Directed Molecular Evolution;Eukaryota;Eukaryotic Cell;Genetic Code;Human;improved;In Vitro;in vivo;innovation;interest;Knowledge;Life;Mammalian Cell;Mass Spectrum Analysis;Modeling;Modification;novel;Organism;Performance;Play;Post-Translational Protein Processing;Property;protein protein interaction;Proteins;Proteome;Proteomics;Reader;reconstitution;Role;Site;System;Technology;Tissues;tool;Viral Vector;virtual

PROJECT_TITLE: A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Public Health Relevance Statement (Narrative) Schizophrenia is the 5th leading cause of disability in the world, affecting 51 million people in which patients suffer from cardinal deficits in self-agency (i.e., the fundamental experience of being the agent of one's own thoughts and actions). These deficits directly contribute to debilitating psychotic symptoms, and show limited response to pharmacological treatments with up to 40% of patients with schizophrenia (SZ) remaining symptomatic, thus compelling the need to identify the neurophysiology underlying self-agency deficits to guide new treatment development. Findings from this proof-of-concept study will delineate: (i) the underlying cognitive and neural cause of self-agency deficits in schizophrenia, (ii) responsiveness to new neurostimulation interventions targeting a novel neural target in the medial prefrontal cortex, and (iii) mechanisms of durability and generalizability, revealing how improvements in critical self-agency abilities can generalize to improvements in general cognition, symptoms and life quality in schizophrenia for future TMS treatment development.

PI_NAMEs: SUBRAMANIAM, KARUNA  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Affect;auditory feedback;Behavior Therapy;Behavioral;Biological;Biological Assay;Cognition;Cognitive;cognitive training;Data;Development;disability;Disease;Distal;effective therapy;experience;Frequencies;Future;Goals;Hearing;improved;Intervention;Judgment;Magnetoencephalography;Measures;Medial;Mediating;memory retrieval;Modeling;Monitor;neural;neural correlate;neural network;Neurobiology;neuromechanism;neurophysiology;neuroregulation;novel;Outcome;Output;Patients;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Prefrontal Cortex;Psychoses;psychotic;psychotic symptoms;public health relevance;Quality of life;Randomized, Controlled Trials;Regimen;repetitive transcranial magnetic stimulation;Research;response;Retrieval;Role;Schizophrenia;Speech;Symptoms;Testing;therapy development;Thinking;Time;Transcranial magnetic stimulation

PROJECT_TITLE: Causal Role of Medial Prefrontal Neural Activity in Self-Agency in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Estrogen;Nutrition;Obesity

ORG_CITY: ALBUQUERQUE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE  Obesity is the second most common cause of preventable death behind smoking, and is often associated with the risk of developing other comorbidities such as hypertension, diabetes mellitus, cardiovascular disease, hyperlipidemia, among others. Our preliminary results suggest a potential intervention for obesity with the G protein-coupled estrogen receptor (GPER) contributing favorable outcomes, which may challenge the current insufficient therapeutic treatment options available to date. This proposal seeks to investigate the direct effects of GPER in adipocytes pertaining to lipid homeostasis, oxidative stress, inflammation, and mitochondrial function.

PI_NAMEs: KO, RANDY  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Adipocytes;adipokines;Adult;aged;Agonist;antagonist;Anti-Inflammatory Agents;antioxidant enzyme;Atherosclerosis;Biological Assay;Biological Models;Body System;Body Weight;Cardiovascular Diseases;Caring;Cell Line;Cell Survival;Cells;Chronic;comorbidity;Complex;cost;CRISPR/Cas technology;cytokine;Desire for food;Diabetes Mellitus;Disease;Disease Progression;drug development;ESR1 gene;Estradiol;Estrogen Nuclear Receptor;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Exhibits;Fatty acid glycerol esters;Female;Gene Expression;Generations;Genes;Genus Hippocampus;Goals;GPER gene;Homeostasis;Hormones;Hydrogen Peroxide;Hyperlipidemia;Hypertension;improved;in vivo;Inflammation;Inflammatory;inflammatory marker;inhibitor;Interleukin-1 beta;Interleukin-6;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver diseases;male;Mediating;Medical;Membrane;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;Mus;National Health and Nutrition Examination Survey;non-genomic;novel therapeutics;Obese Mice;Obesity;obesity treatment;Outcome;Overweight;Oxidative Stress;Pathway interactions;Physiological;Physiological Processes;Play;preventable death;protein expression;Public Health;Receptor Activation;receptor expression;Receptor Signaling;Regulation;reproductive development;Respiration;Risk;Role;Signal Transduction;Smoking;Stress Tests;Supplementation;Systems Development;Testing;Therapeutic;therapeutic development;Time;Tissues;TNF gene;treatment strategy;United States;Weight Gain;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Role of GPER in Obesity and Lipid Metabolism.


ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Somatic mutations and modifiable factors interact to drive the development of clonal hematopoiesis (CH) and its transformation to hematologic malignancy. How to stratify risk for patients remains a significant open question, as not all patients with dominant clones go on to develop CH, and not all those with CH go on to develop cancer. In three synergistic mouse and human projects, our Program will identify how extrinsic stressors interact with specific genetic mutations to influence the clonal expansion and malignant transformation of hematopoietic stem and progenitor cell clones in order to inform clinical guidance of individuals with CH.

PI_NAMEs: GOODELL, MARGARET A. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acceleration;Adult;Age;age related;Apoptosis;Atherosclerosis Risk in Communities;Attenuated;Automobile Driving;Bioinformatics;Black race;Blood specimen;Bone Marrow;cancer prevention;Cells;chemotherapy;cigarette smoking;Clinical;Clonal Expansion;Clone Cells;cohort;Collaborations;Communities;Coupled;Data;Development;Disease;DNA Damage;DNA Sequence Alteration;DNMT3a;Ensure;epidemiological model;epidemiology study;Epigenetic Process;Etiology;Evolution;exome sequencing;Exposure to;Female;Gene Mutation;Genes;Genotoxic Stress;genotoxicity;Goals;Health;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;High Fat Diet;Human;Incidence;Individual;Infection;Inflammation;Inflammatory;Infrastructure;Intervention;Longevity;Malignant - descriptor;Malignant Neoplasms;Measures;Metabolic;metabolomics;Methylation;Modeling;modifiable risk;mortality;mosaic;mouse model;Multiomic Data;Mus;mutant;Mutation;non-genetic;novel;Obesity;older adult;Older Population;Outcome;Oxidative Stress;Participant;Pathway interactions;Patients;peripheral blood;Persons;Precancerous Conditions;premalignant;Prevention strategy;Production;programs;Proteomics;Publications;Recording of previous events;Records;Recurrence;Research Personnel;response;Risk;Risk Factors;risk mitigation;risk stratification;Role;Sampling;Scientist;single cell sequencing;Smoking;Somatic Mutation;stem cell expansion;Stress;stressor;Study models;success;Testing;Time;transplant model;Validation;Variant

PROJECT_TITLE: Modifiable Drivers of Expansion and Malignant Transformation from Clonal Hematopoiesis


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

PHR: Project Narrative Our proposed research is in-line with the mission of the NEI to advance knowledge of the neural mechanisms of visual function. We expect our proposed research to significantly advance the understanding of how the microstructure and function of the human visual system develops during the first two years of life. The outcome of our research will improve the well-being of individuals in society as it will provide foundational knowledge leading to the development of noninvasive biomarkers to diagnosis atypical development of visual cortex in infants, leading the way to early inventions and better life-long outcomes.

PI_NAMEs: GRILL-SPECTOR, KALANIT  (contact);PAREDES, MERCEDES

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Age;area striata;Astrocytes;Biological;Biological Markers;Brain;Categories;cell type;Cells;Childhood;Clinical;clinically significant;Collaborations;computerized tools;Contrast Sensitivity;Coupled;Custom;Data;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;extrastriate visual cortex;Functional Magnetic Resonance Imaging;Gene Expression;Generations;Genes;Goals;gray matter;Histologic;Histology;Human;Human Development;Imaging Device;imaging modality;improved;in vivo;Individual;infancy;Infant;Infant Development;innovation;invention;Iron;Knowledge;Life;Link;Measurement;Measures;Methodology;Methods;Mission;Molecular;Multimodal Imaging;multimodal neuroimaging;Myelin;myelination;neuroimaging;neuromechanism;Neurons;novel;Oligodendroglia;open source;Outcome;Pathway interactions;Personal Satisfaction;Proliferating;Relaxation;Research;response;Sampling;Signal Pathway;Societies;Structure;Systems Development;Temporal Lobe;Testing;Tissue Sample;Tissue-Specific Gene Expression;Tissues;tool;transcriptomics;Vision;vision development;Visual;Visual Cortex;Visual System;Vulnerable Populations;white matter

PROJECT_TITLE: Visual Cortex as a Window to Microstructural and Functional Development of the Human Brain

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative By unveiling new molecular and pathogenic mechanisms that account for clonal hematopoiesis (CH) and hematologic malignancies, Project 1 of our Program is tightly aligned with the NCI mission. Our studies will provide important insights on how the modifiable stressors of infection and high-fat diet-induced obesity exert selective advantages on hematopoietic stem and progenitor cells (HSPCs) with CH-associated mutations and promote to their malignant transformation. Our discoveries will define the mechanisms by which CH progresses toward malignancy and provide the groundwork for risk stratification of CH-associated mutations.

PI_NAMEs: KING, KATHERINE YUDEH (contact)

PROJECT_TERMS: Acceleration;Affect;Age;Anti-Inflammatory Agents;Attenuated;Blood Cells;Cells;Chronic;Clonal Expansion;Clone Cells;cohort;Communities;cytokine;Cytokine Receptors;Data;data sharing;DDR1 gene;Detection;Development;diet-induced obesity;disorder prevention;DNA methylation profiling;DNA Repair Pathway;DNMT3a;Drug Receptors;Epigenetic Process;epigenetic profiling;FLT3 gene;Genes;Genotoxic Stress;Goals;Head;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Heritability;Heterozygote;High Fat Diet;high risk;Histones;Human;Individual;Infection;Inflammation;Inflammatory;innovation;insight;Intervention;Investigation;leukemia;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metformin;Mission;Modeling;modifiable risk;Molecular;mosaic;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Mycobacterium avium;novel;Obesity;Outcome;Pathogenicity;peripheral blood;Persons;Pharmaceutical Preparations;Play;Population;Precancerous Conditions;Prevalence;Production;programs;Proteomics;Regimen;Research;response;Risk;Risk Factors;risk stratification;RNA Splicing;Role;Signal Transduction;single-cell RNA sequencing;Somatic Mutation;Stress;stressor;Technology;Testing;Time;transcriptomics;transplant model;Transplantation;Work

PROJECT_TITLE: Project 1: Effects of inflammation on clonal competition and malignant transformation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The proposed research will evaluate the individual and combined effects of task-specificity and intensity of rehabilitation interventions on locomotor function, community mobility and quality of life in patients with subacute (1-6 months) post-stroke. The primary hypothesis is that practice of specific walking tasks early post- stroke at very high intensities will maximize health and function.

PI_NAMEs: HORNBY, THOMAS GEORGE (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Adherence;Adverse event;adverse event risk;Alternative Therapies;Attention;Blinded;Cardiopulmonary;cardiovascular risk factor;Cardiovascular system;Chronic;chronic stroke;clinical implementation;clinical practice;clinical translation;Clinical Trials Design;Communities;comparative efficacy;conventional therapy;cost;cost effectiveness;Data;Educational Intervention;Equilibrium;Event;Exercise;exercise intensity;exercise intervention;exercise training;Face;fitness;follow-up;Gait;Gait speed;gait symmetry;Goals;Health;Health Services;Human Resources;Impairment;improved;improved mobility;Incidence;Individual;Inferior;Injury;innovation;Intervention;Joints;kinematics;Laboratories;Locomotor Recovery;Measures;Metabolic;Movement;Multicenter Studies;Nervous System Trauma;neurological recovery;Neuronal Plasticity;Outcome;Participant;Patients;Pattern;Persons;Phase;Phase II Clinical Trials;post stroke;primary outcome;Productivity;Quality of life;randomized, clinical trials;Recovery;Rehabilitation therapy;Research;Risk;robotic device;spatiotemporal;Specificity;Speed;Step training;Stroke;Testing;theories;Training;treadmill;Walking;Work

PROJECT_TITLE: Variable Intensive Early Walking post-Stroke (VIEWS)

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Dengue and Zika are diseases of major importance worldwide, but surveillance, epidemic preparedness, and control are complicated by immunological cross-reactivity between dengue and Zika viruses (DENV and ZIKV), particularly in dengue-endemic Latin America after the explosive 2015-2016 Zika pandemic. It is critical for dengue and Zika vaccine evaluation and implementation, epidemic preparedness, and public health research to improve differential detection of prior infections by DENV and ZIKV and increase our understanding of how immunological cross-reactivity affects serological testing, seroprevalence estimation, viral transmission, and protection and/or enhancement of future flaviviral disease. Following upon our recent work showing that immunological asymmetries exist among the four DENV serotypes and ZIKV and that pre-existing immunity to ZIKV can enhance subsequent DENV2 infection and disease, this R01 will use new serological assays, diverse modeling approaches, and state-of-the-art methods for antibody analysis to study samples and data from the longest-running dengue/Zika cohort study and extend this unique Nicaraguan cohort into the next critical phase of flaviviral disease in the tropics and subtropics where infection and disease outcomes are modulated by widespread ZIKV immunity.

PI_NAMEs: HARRIS, EVA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Aedes;Affect;Age;age related;Algorithms;Americas;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Area;assay development;Biological Assay;Biophysics;Characteristics;Child;Childhood;Clinical Data;cohort;Cohort Studies;Communities;companion diagnostics;Companions;congenital zika syndrome;cross reactivity;Culicidae;Data;Data Analyses;Dengue;Dengue Hemorrhagic Fever;Dengue Infection;Dengue Shock Syndrome;Dengue Vaccine;Dengue Virus;design;Detection;Development;Diagnostic;diagnostic assay;Disease;Disease Outcome;disease transmission;disorder risk;e Antigens;E protein;Engineering;Ensure;env Gene Products;Enzyme-Linked Immunosorbent Assay;Epidemic;epidemic preparedness;epidemiologic data;epidemiological model;Epidemiology;epidemiology study;Epitopes;Evaluation;experimental study;Flavivirus;Flavivirus Infections;Future;future epidemic;Guillain Barré Syndrome;Household;Immune;Immunity;Immunologics;improved;Individual;Infection;infection risk;innovation;insight;Kinetics;Knowledge;Lateral;Latin America;Licensing;Licensure;Life;Machine Learning;Masks;Measures;Mediating;Methods;Modeling;Monoclonal Antibodies;Nicaragua;Nicaraguan;novel;novel vaccines;pandemic disease;Pathogenesis;Pathogenicity;Phase;Polysaccharides;Population;Populations at Risk;Predisposition;Prevalence;programs;Prospective, cohort study;public health research;Recording of previous events;Research;response;Risk;Running;Sampling;Sampling Studies;Sensitivity and Specificity;Serology;Serology test;Seroprevalences;Serotyping;Serum;Severities;Severity of illness;sex;Specificity;System;Testing;Time;tool;transmission process;Vaccine Clinical Trial;vaccine efficacy;vaccine evaluation;vaccine safety;vaccine trial;Vaccines;viral transmission;Virus;Work;ZIKA;Zika Virus;Zika virus vaccine;ZIKV disease;ZIKV exposure;ZIKV infection

PROJECT_TITLE: Living in the post-Zika world: Impact of interactions between dengue and Zika viruses on diagnostics, antibody dynamics, and correlates of disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(02)]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Modifiable external stressors, including certain chemotherapies and exposure to cigarette smoke, increase the risk of hematologic malignancies through a poorly understood process. Our study will investigate how chemotherapies and cigarette smoke promote the expansion of hematopoietic stem and progenitor cells carrying mutations in the DNA damage response pathway to cause clonal hematopoiesis (CH), and how CH progresses toward malignancy in this context. Results from this Project will not only unveil the mechanisms behind CH development and malignant transformation, but may also uncover potential interventions to prevent CH and its progression to hematologic malignancies.

PI_NAMEs: NAKADA, DAISUKE  (contact)

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Apoptosis Promoter;Ascorbic Acid;Biological Assay;Bone Marrow;Carboplatin;Cardiovascular Diseases;Cell Cycle;cell transformation;cell type;Cells;CHEK2 gene;chemotherapy;cigarette smoke;Cisplatin;Clonal Expansion;Collaborations;Combined Modality Therapy;Cysteine;cytotoxic;Data;data sharing;Development;digital;DNA Damage;DNA Repair;DNMT3a;Ensure;Environment;Etoposide;experimental study;Exposure to;exposure to cigarette smoke;FLT3 gene;Genes;genome sequencing;Genotoxic Stress;genotoxicity;Goals;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic stem cells;high risk;Human;human data;Individual;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Intervention;Malignant - descriptor;Malignant Neoplasms;Melphalan;Metformin;Methods;MLL-AF9;Modeling;mortality;mosaic;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Non-Steroidal Anti-Inflammatory Agents;novel;older adult;Oncogenes;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;PPM1D gene;pressure;prevent;Process;programs;reconstitution;Recurrence;Replication Error;Reproducibility;Resistance;response;Risk;Role;single cell sequencing;Smoking;stressor;Symptoms;Testing;TP53 gene;Transplantation;Variant;whole genome;Work

PROJECT_TITLE: Project 2: The role of the DNA damage response in clonal competition following genotoxic stress


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative A decrease in skeletal muscle mass is of clinical importance because it is associated with increased morbidity and mortality, as well as a marked deterioration in the quality of life. A broad patient population is affected by significant losses in muscle mass including those afflicted by various systemic diseases, chronic physical inactivity and sarcopenia. The purpose of this grant is to better understand the role of skeletal muscle stem cells (satellite cells) in the blunted growth response to exercise in the elderly, thereby providing a foundation for their therapeutic use to prevent or restore losses in skeletal muscle mass during aging.

PI_NAMEs: MCCARTHY, JOHN JOSEPH (contact);WEN, YUAN

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Ablation;Adult;Affect;Age;age related changes;aged;Aging;Cell Communication;Cell Nucleus;Cells;Chronic;Clinical;Collagen;Communication;Deterioration;Doxycycline;Elderly;Endothelial Cells;Exercise;Extracellular Matrix;extracellular vesicles;Female;Fibroblasts;Fibrosis;Foundations;Gene Expression;Genes;Genetic Transcription;Grant;Growth;Human;human old age (65+);Hypertrophy;Immunohistochemistry;Impairment;In Vitro;in vivo;intercellular communication;interest;Label;male;Mechanics;Messenger RNA;MicroRNAs;Modeling;Molecular;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;muscle aging;muscle form;muscle hypertrophy;muscle progenitor cell;Muscle satellite cell;Muscular Atrophy;Natural regeneration;novel;old mice;Output;patient population;Phenocopy;physical inactivity;Plantaris muscle;Population;Population Dynamics;postnatal;prevent;Process;Production;progenitor;Quality of life;Reporter;Reporting;Repression;response;Rodent;Role;sarcopenia;single-cell RNA sequencing;Skeletal Muscle;skeletal muscle growth;skeletal muscle wasting;stem cells;stemness;Stimulus;Systemic disease;Tamoxifen;Testing;Therapeutic;Therapeutic Uses;Time;Transcript;transcriptome;transcriptome sequencing;Wasting Syndrome;young adult

PROJECT_TITLE: The role of satellite cells in skeletal muscle hypertrophy with aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE  Genetic variation contributes to the observable diversity in biological traits found within single species. High levels of genetic variation exist between strains of the most clinically relevant human fungal pathogen, Candida albicans, but the consequences of this variation on its ability to cause disease is significantly understudied. Understanding the genetic differences in C. albicans that lead to more or less severe clinical disease will help identify potential therapeutic targets to reduce the burden of C. albicans pathogenesis.

PI_NAMEs: ANDERSON, MATTHEW Z (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adherence;Adhesions;Agar;Benign;Biological;Biology;Blood Circulation;Candida;Candida albicans;Candidate Disease Gene;Candidiasis;cell growth regulation;cell injury;Cell Physiology;Cells;Clinical;clinically relevant;Detection;Development;differential expression;Disease;Disease Outcome;Disparate;Endocytosis Induction;Epithelial Cells;Epithelium;Equilibrium;Esophagus;experimental study;Filament;fitness;fungus;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;genetic approach;Genetic Determinism;Genetic Polymorphism;Genetic Screening;Genetic Transcription;Genetic Variation;genome-wide;Growth;HIV;Human;human pathogen;Hyphae;Immune response;Immunocompetent;Immunocompromised Host;In Vitro;in vivo;in vivo evaluation;Incubated;Individual;insight;Integration Host Factors;interest;Invaded;Investigation;Life;Link;Liquid substance;Maps;Measures;migration;mouse model;Mucous Membrane;Mus;mutant;novel;Nutritional;opportunistic pathogen;Oral;Oral candidiasis;Oral cavity;oral cavity epithelium;oral infection;Oral mucous membrane structure;Oropharyngeal;oropharyngeal thrush;Partner in relationship;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Penetration;Phagocytes;Phenotype;Ploidies;Predisposition;Process;Production;programs;Property;Quality of life;Quantitative Genetics;Quantitative Trait Loci;Recombinants;response;Role;Signal Transduction;Skin;Solid;Surface;Symbiosis;System;Systemic disease;Systemic infection;Testing;therapeutic target;tissue culture;Tissues;trait;transcriptome sequencing;uptake;urogenital tract;Variant;virtual;Virulence;wasting;Work;Yeasts

PROJECT_TITLE: Quantitative genetic approaches to Candida albicans pathogenesis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Prevention

PHR: Project Narrative As a complement to experimental mouse models in Projects 1 and 2, the human Project in the P01 Project 3 is designed to identify modifiable risk factors for clonal expansion and malignant transformation in an epidemiologic study. Identifying common, modifiable factors that drive clonal expansion and further transformation to hematologic malignancy is closely aligned with the mission of the NCI, as it will provide opportunities to intercept clonal expansion and malignant transformation and enable increased screening and early detection of clonal hematopoiesis in persons at higher risk of hematologic malignancy due to their combined genetic and modifiable risk factor profile.

PI_NAMEs: PLATZ, ELIZABETH A. (contact)

PROJECT_TERMS: Address;adjudication;Administrative Coordination;Age;Anti-Inflammatory Agents;Aspirin;Atherosclerosis Risk in Communities;Black race;Cells;CHEK2 gene;Classification;Clonal Expansion;Clone Cells;cohort;Cohort Studies;Communities;Complement;cytokine;Data;Dependence;design;DNA Damage;DNA Sequence Alteration;DNA sequencing;DNMT3a;Early Diagnosis;epidemiology study;Evolution;exome sequencing;experimental study;Female;fitness;follow-up;Gene Frequency;Genes;Genetic Risk;genetic variant;Genomics;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic stem cells;high risk;Human;Individual;Inflammation;Inflammatory;Intercept;Intervention;JAK2 gene;Leukocytes;Malignant - descriptor;Malignant Neoplasms;mathematical model;Measures;Methylation;Mission;modifiable risk;mouse model;Mus;Mutate;Mutation;Myelogenous;Myeloproliferative disease;novel;Obesity;older adult;Participant;peripheral blood;Persons;Pharmaceutical Preparations;PPM1D gene;Prevalence;programs;prospective;Proteomics;Recurrence;Resolution;Resources;response;Risk;Risk Factors;screening;single cell analysis;single cell sequencing;Smoking;Testing;Time;TP53 gene;Variant;Visit

PROJECT_TITLE: Project 3: Contribution of inflammation and DNA damaging factors to clonal expansion and malignant transformation in a community cohort of older adults


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics;Neurosciences;Sleep Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Although we spend one third of our lives asleep, the molecular mechanisms that regulate sleep remain poorly understood. We will use the powerful and genetically accessible fruit fly to characterize several evolutionarily conserved genes that link brain development and the control of adult sleep-wake cycles. Because these genes are shared with humans, our studies may have broad implications for understanding normal sleep and for the diagnosis and treatment of sleep dysfunction.

PI_NAMEs: STAVROPOULOS, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;Anatomy;Apical;autism spectrum disorder;Biological Models;Biology;Brain;Brain region;Chemicals;clinically relevant;Clone Cells;Complex;cullin-3;Data;Dendrites;Development;Diagnosis;Drosophila genus;Dystonia;Extramural Research Program;fly;G-Protein-Coupled Receptors;gene conservation;Genes;Genetic;Goals;GTP-Binding Protein beta Subunits;Human;in vivo;insight;Lead;Life;Link;locomotor control;Mammals;Molecular;Molecular Target;Morphogenesis;Mus;Mushroom Bodies;Mutagenesis;mutant;Mutation;Nervous System Disorder;Neuroanatomy;neuroblast;Neurodevelopmental Disorder;neuron development;neuronal circuitry;Neurons;Neurosciences;Orthologous Gene;Output;Pathway interactions;postmitotic;Proliferating;Shapes;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep regulation;sleep regulatory center;Sleep Wake Cycle;Specific qualifier value;Stroke;Structure;Synapses;Testing;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Development and Function of Sleep Circuits - Extramural Research Programs in the Neurosciences and Neurological Disorders

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Neutrophils are circulating white cells and the recruitment of neutrophils to the sites of inflammation is a hallmark of the innate immune response. We have shown that neutrophils possess the ability to crawl against the direction of shear flow, and our goal is to identify the key receptors and signals that control upstream migration in neutrophils. We hypothesize that upstream migration helps neutrophils to reach the sites of inflammation faster, and manipulating the factors that aid upstream migration may lead to new ways of treating inflammatory disease.

PI_NAMEs: HAMMER, DANIEL A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Actins;Acute;Adhesions;Antibodies;B-Lymphocytes;Binding;Biological Assay;Blood;Blood Vessels;Cell Adhesion Molecules;cell motility;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complication;disabled;Disease;Endothelial Cells;Endothelium;Engineering;Event;experimental study;Extravasation;fascinate;first responder;Generations;genetic manipulation;Goals;Greater sac of peritoneum;Hematopoietic;Hematopoietic stem cells;HL-60 Cells;Image;Immune;improved;In Vitro;in vivo;Infectious Agent;Inflammation;Inflammatory;Innate Immune Response;Integrin alpha4beta1;Integrins;Intercellular adhesion molecule 1;Knock-out;Laboratories;Leukocyte Trafficking;Leukocytes;Ligands;Lymphocyte;lymphocyte function associated antigen;Lymphocyte Function-Associated Antigen-1;Lymphoid;Macrophage-1 Antigen;Measurement;Measures;mechanotransduction;Mediating;migration;Migration Assay;Molecular;Monoclonal Antibodies;monolayer;mouse model;mutant;Myelogenous;neutrophil;Neutrophil Infiltration;Paper;Pathway interactions;Patient-Focused Outcomes;Physiological;PIK3CG gene;polymerization;Polymers;Population;postcapillary venule;preference;receptor;recruit;Role;Secure;Signal Pathway;Signal Transduction;Site;stem cells;Stimulus;Stream;Stress;Surface;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Traction;Traction Force Microscopy;trafficking;Vascular Cell Adhesion Molecule-1;Work

PROJECT_TITLE: Controlling the upstream migration of neutrophils by manipulating the function of Mac-1 and LFA-1

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Hematology

PHR: Project Narrative The Administrative Core (Core B) will coordinate smooth running of the overall program, ensuring communication, fiscal responsibility, and evaluation and ethical standards among participants of all five institutions.

PROJECT_TITLE: Core B: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because we are generating new computer-aided methods aimed at improving diagnostic quality, reducing intra- and inter-observer variability that will ultimately enable efficient patient selection for personalized cancer therapies. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to the application of novel strategies that may improve human health.

PI_NAMEs: CHEN, WEI  (contact);NIAZI, MUHAMMAD KHALID KHAN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Agreement;American;American Cancer Society;automated assessment;automated image analysis;Biological;Cancer Etiology;cancer risk;cancer type;Cell Adhesion;Cell Nucleus;Cell Polarity;Cells;Cessation of life;chemotherapy;Clinical;Clinical Management;cohort;college;colon cancer patients;Color;Colorectal;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;Compensation;computer aided detection;Computer Assisted;Computer software;Computer-Assisted Image Analysis;Consensus;Consumption;Cytokeratin;Decision Making;deep learning;deep learning algorithm;deep learning model;Detection;Diagnostic;differential geometry;Disease;Disease-Free Survival;disorder risk;epithelial to mesenchymal transition;Evaluation;Exclusion;experience;Future;Guidelines;Head and Neck Squamous Cell Carcinoma;Health;Hematoxylin and Eosin Staining Method;Human;Image;Image Analysis;image registration;improved;improved outcome;Incidence;innovation;International;Interobserver Variability;Large Intestine Carcinoma;Learning;Learning Module;lifetime risk;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Manuals;Mathematics;men;Metastatic Neoplasm to Lymph Nodes;Methods;Microsatellite Instability;Mission;Modality;Modeling;Morphology;mortality;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Outcome;outcome prediction;Pathologic;Pathologist;Pathology;Pathology Report;Patient Care;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;Performance;personalized cancer therapy;Play;Prevalence;Prognostic Factor;Progression-Free Survivals;Protocols documentation;Public Health;Qualifying;quantitative imaging;Recommendation;Regional Anatomy;Reproducibility;Research;risk stratification;Role;Scientist;Shapes;Slide;Software Tools;Specimen;Squamous cell carcinoma;Stains;Standardization;Statistical Data Interpretation;symposium;System;Systems Analysis;Techniques;theories;Time;tool;Training;tumor;Tumor stage;United States;United States National Institutes of Health;Variant;Visual;whole slide imaging;Woman;Work

PROJECT_TITLE: An ensemble deep learning model for tumor bud detection and risk stratification in colorectal carcinoma.

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Diabetes;Genetics;Nanotechnology;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Impaired immune cell response leading to chronic inflammation is a major cause of non-healing diabetic wounds. We have identified that increased Notch signaling in diabetic wounds polarizes CD4+T cells in the wound towards an inflammatory TH17 phenotype. This proposal will seek to understand the mechanisms responsible for the altered Notch signaling and will test new cell-targeted nanotherapies to restore immune cell homeostasis and healing in wounds.

PI_NAMEs: GALLAGHER, KATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Amputation;Antibodies;Artificial nanoparticles;Blood specimen;CD4 Positive T Lymphocytes;Cells;cellular targeting;Chronic;Data;Death Rate;Defect;Dermal;Diabetes Mellitus;diabetic;diabetic ulcer;diabetic wound healing;diet-induced obesity;dietary;Ensure;Enzymes;Epigenetic Process;experimental study;Failure;Fibroblasts;Functional disorder;Gene Expression;Genetic;healing;histone methyltransferase;Homeostasis;Human;IL17 gene;Immune;Immune response;Impaired healing;Impaired wound healing;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;inhibitor therapy;Injury;keratinocyte;Ligands;Local Therapy;Macrophage;Malignant Neoplasms;Mediating;Methods;MLL gene;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nanotherapy;non-diabetic;non-healing wounds;Non-Insulin-Dependent Diabetes Mellitus;Normal tissue morphology;notch protein;novel;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Play;prevent;Publishing;receptor;Receptor Activation;receptor expression;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;response;Role;Signal Transduction;skin wound;T cell differentiation;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;tissue repair;Tissue Sample;Tissues;TLR4 gene;wound;wound healing

PROJECT_TITLE: Notch signaling in diabetic wounds

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Hematology;Human Genome;Networking and Information Technology R&D (NITRD);Obesity;Precision Medicine;Prevention

PHR: Project Narrative The Single Cell Sequencing and Bioinformatics Core (Core A) will provide all Projects with technical and analytical platforms and bioinformatic support to enable lineage tracing and measure molecular responses of both human and murine mutant cells at single-cell resolution. In addition, this Core will use the large-scale epidemiologic data from Project 3 to develop a mathematical model to predict the risk that clonal hematopoiesis transforms into frank hematologic malignancy in older adults. This Core is critical to understanding how cells with specific mutations respond to various modifiable stressors and thus the overall mission of this Program.

PI_NAMEs: TAKAHASHI, KOICHI  (contact)

PROJECT_TERMS: Animals;Bioinformatics;bioinformatics resource;Biological;Biometry;bisulfite sequencing;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemotherapy;Chromium;Clinical;Clinical Management;clinically relevant;cohort;Communities;Complex;Computer Analysis;Computer software;Cross-Sectional Studies;Data;Data Analyses;data integration;data quality;data repository;Data Set;data sharing;Data Storage and Retrieval;design;Development;DNA;DNA sequencing;Early Diagnosis;Ecosystem;Ensure;Environmental Risk Factor;epidemiologic data;epidemiology study;Epigenetic Process;epigenomics;Evolution;experience;Exposure to;Gene Frequency;Generations;genetic variant;genomic platform;Genomics;Goals;Growth;Hematologic Neoplasms;Hematopoiesis;Human;Individual;Infection;large scale data;Lead;leukemia;Malignant - descriptor;Malignant Neoplasms;mathematical analysis;mathematical model;Measures;Methodology;Mission;modifiable lifestyle factors;modifiable risk;Molecular;Molecular Analysis;Molecular Epidemiology;molecular scale;multidimensional data;multiple omics;Mus;mutant;Mutation;novel;Obesity;older adult;Patients;Positioning Attribute;predictive tools;Prevention;Prevention approach;programs;Protein Analysis;Quality Control;Reproducibility;Resolution;response;Rice;Risk Factors;risk prediction;risk prediction model;risk stratification;sequencing platform;single cell analysis;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Smoking;Statistical Models;stem cell model;Stress;stressor;Technology;tool;transcriptome sequencing;transcriptomics;Universities;Work

PROJECT_TITLE: Core A: Single Cell Profiling and Bioinformatics Core


PHR: Project Narrative This research program will delineate the structural and molecular mechanisms by which hormone-bound progesterone receptor regulates gene transcription that underpins female reproductive processes. Innovative cryo-electron microscopy and structural proteomic approaches, together with inventive in vitro and cell-based assays and state-of-the-art engineered mouse models will elucidate the unique structural importance of a defined functional domain in the progesterone receptor. Accordingly, research outcomes from these investigations will significantly advance our fundamental understanding not only of progesterone control of female reproductive biology but also gynecologic disorders that lead to infertility and other reproductive morbidities.

PI_NAMEs: O'MALLEY, BERT W (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Address;AF2;Ally;Androgen Receptor;Binding;Biological Assay;Biology;Cell Line;Cell Physiology;Cell-Free System;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Decidual Cell Reactions;Dependence;Disease;DNA;DNA Binding;Endocrinology;Endometrial;Endometrial Stromal Cell;Engineering;Enhancers;EP300 gene;Estrogen Receptors;Female;flexibility;Funding;Genetic Transcription;Genome;Gonadal Steroid Hormones;Grant;Gynecologic;Hormone Receptor;Hormones;Human;Human Engineering;In Vitro;in vivo;Infertility;innovation;insight;Investigation;Knowledge;Length;Mediating;Methods;Modeling;Molecular;Molecular Conformation;mouse model;Mus;mutant;novel;Nuclear Hormone Receptors;Nuclear Receptors;Outcomes Research;Output;particle;Phenotype;Physiological;Process;Progesterone;progesterone receptor A;progesterone receptor B;Progesterone Receptors;programs;Proliferating;promoter;Protein Isoforms;Proteomics;receptor;Receptor Activation;Receptor Gene;recruit;Reproduction;Reproductive Biology;reproductive function;reproductive morbidity;Reproductive Process;Research;response;Role;steroid hormone;Structure;Structure-Activity Relationship;System;Technology;therapeutic target;three dimensional structure;Tissues;Transactivation;Transcriptional Activation;Transcriptional Regulation;Visualization;Whole Organism

PROJECT_TITLE: Sex Hormone Receptor Component And The Cell Genome

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE: Neuropsychiatric complications including depression and cognitive decline develop, persist, and even worsen in the years after traumatic brain injury (TBI), negatively affecting the quality of life and lifespan. Mounting evidence indicates that chronic inflammatory processes are active, but the mechanism that drives this response is unclear. Based on our collective data, we hypothesize that increased type I interferon signaling is critical in promoting microglial priming and the subsequent transition from acute inflammation to chronic neuroinflammation after TBI. Therefore, we will use strategies to characterize cell specific responses to TBI, attenuate interferon signaling, and force the turnover of microglia to protect against TBI-induced microglia priming, chronic neuroinflammation, and cognitive impairment.

PI_NAMEs: GODBOUT, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Address;Affect;antagonist;Anxiety;Astrocytes;Atrophic;Attenuated;Behavior;Behavioral;Brain;Cells;Chronic;Chronic Phase;Clinical;Cognition;Cognitive;Cognitive deficits;CSF1R gene;Cyclophosphamide;Data;depressive symptoms;Deterioration;Diffuse;Disease;Distress;experimental study;fluid percussion injury;Genetic Transcription;glial activation;Hippocampus;Homeostasis;Immune;Immune response;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Interferon alpha;Interferon Receptor;Interferon Type I;Interferons;Intervention;life span;Macrophage;Mediating;Mental Depression;Microglia;Mus;Nerve Degeneration;neuroinflammation;Neuronal Plasticity;Neurons;neuropathology;neuropsychiatry;novel;Oligodendroglia;Pathology;Pathway interactions;Phase;Phase Transition;Population;prevent;Process;Production;promoter;Quality of life;Receptor Activation;Reporting;response;RNA;Secondary to;Signal Transduction;single-cell RNA sequencing;Time;transcriptome;Trauma;Traumatic Brain Injury

PROJECT_TITLE: Chronic and Evolving Inflammation after Traumatic Brain Injury: Microglial Priming and Neuropsychiatric Complications

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Oral cavity squamous cell carcinoma is a lethal disease often preceded by premalignant lesions making it an ideal disease for screening initiatives. However, current methods cannot reliably differentiate between reactive/inflammatory and dysplastic lesions. Our overall goals are to establish molecular-based prognostic and screening tests to identify high-risk patients most likely to progress to cancer thereby providing lead-time for earlier and potentially more curative interventions.

PI_NAMEs: AGRAWAL, NISHANT  (contact);LINGEN, MARK W.

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Biological Markers;Biopsy;cancer diagnosis;Categories;Clinical;cohort;Cohort Studies;Collection;Control Groups;Coupled;curative treatments;Detection;Devices;Diagnosis;diagnostic accuracy;Diagnostic tests;Disease;DNA Sequence Alteration;driver mutation;Dysplasia;Eligibility Determination;Genes;Goals;Head and Neck Squamous Cell Carcinoma;Health;high risk;high risk population;Histologic;Human;Hyperplasia;improved;Incidence;Inflammatory;innovation;Lead;Lesion;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Methods;Modality;Molecular;Morbidity - disease rate;mortality;mouth squamous cell carcinoma;Mutation;Mutation Detection;next generation sequencing;novel;Oral;Oral Diagnosis;oral dysplasia;oral lesion;oral premalignancy;oral tissue;Outcome;Pathogenesis;Patients;population based;premalignant;Procedures;prognostic;Prognostic Marker;prognostication;Research;Retrospective cohort;risk stratification;Saliva;saliva sample;Salivary;screening;Severe dysplasia;Somatic Mutation;Tactile;targeted sequencing;Testing;Therapeutic;Time;Tissues;United States;Visual;Work

PROJECT_TITLE: Somatic Mutations in Tissue and Saliva as Prognostic and Screening Biomarkers for Oral Premalignancy

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

PHR: Project Narrative This project is to create a training program for graduate students and post-graduate students as well as MD/PHD students to acquire skills to apply Data Science and Artificial Intelligence techniques to genomics of human diseases. Success of the program will contribute to training the next generation of biomedical workforce in the application of state-of-art computation to genomics data.

PI_NAMEs: BUCAN, MAJA ;KIM, JUNHYONG  (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Genomics;Training Programs

PROJECT_TITLE: Training Program in Computational Genomics


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative Intracellular transport of vesicular cargoes, such as insulin granules, by molecular motors along the cell’s cytoskeletal highway is an essential cellular process that is critical to human life. Understanding the molecular underpinnings of this transport process in cells is difficult, due to the investigator’s inability to control the inner workings of the cell. Therefore, this proposal will use an innovative combination of in vitro and in silico model systems in which teams of kinesin and myosin molecular motors navigate physiologically-relevant, lipid-bound cargoes through 3-dimensional cytoskeletal networks, in an effort to define Mother Nature’s design principles that govern intracellular cargo transport.

PI_NAMEs: WARSHAW, DAVID M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actins;Adaptor Signaling Protein;Address;Binding Proteins;Biological Models;biophysical techniques;Cell membrane;Cell Physiology;Cells;Complex;Cytoskeleton;Data;design;Destinations;Electrostatics;Environment;Event;experimental study;Foundations;Human;in silico;In Vitro;in vitro Model;in vivo;innovation;insulin granule;Intracellular Transport;Kinesin;knowledgebase;Life;Link;Lipid Binding;Liposomes;Mechanics;Membrane;Microfilaments;Microtubules;Modeling;Molecular;Molecular Motors;Mothers;Motor;MYO5A gene;Myosin ATPase;Nature;Physically Challenged;Physiological;presynaptic;Property;receptor;Research Personnel;single molecule;Sorting;Surface;Synaptic Vesicles;System;tau Proteins;temporal measurement;Transport Process;Tropomyosin;vesicle transport

PROJECT_TITLE: Cargo Transport by Myosin Va and Kinesin-1 Molecular Motors:  In Vitro Model Systems that Build Complexity in 3-Dimensions.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Dietary Supplements;Eye Disease and Disorders of Vision;Natural Products;Neurosciences;Nutrition;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE Light exposure and oxidative stress can induce photoreceptor cell death in many animal models of inherited human blinding diseases. Emerging evidence suggests a beneficial role of carotenoids in the protection of photoreceptors against this insult. Studying mechanisms of neuroprotection is at the forefront of visual sciences and will provide novel concepts for intervention therapies in the fight against blinding diseases.

PI_NAMEs: VON LINTIG, JOHANNES FRIEDRICH (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Carotenoids in Vision

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Cancer;Cervical Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Lung;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Substance Misuse;Tuberculosis;Women's Health Research

ORG_CITY: Bern

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: UNIVERSITAT BERN

PHR: There has been immense progress in HIV care and prevention – with more than 25 million people living with HIV receiving antiretroviral therapy, more robust antiretroviral drugs, pre-exposure prophylaxis, and differentiated models of care – yet the burden of non-communicable diseases (NCDs) and cancer is rapidly increasing. At the same time, the threat of antiretroviral and anti-tuberculosis (TB) drug resistance continues, and the COVID-19 pandemic illustrates the vulnerability of health services. This application addresses the emerging pertinent research questions with robust epidemiologic research and innovative implementation science to address the interacting burdens of HIV, TB, NCDs, including cancer and mental health and substance use disorders, and emerging diseases such as COVID-19 across the life course, so that the output from this program of work can translate into improved prevention and treatment programs in sub-Saharan Africa and beyond.

PI_NAMEs: CHIMBETETE, CLEOPHAS ;DAVIES, MARY-ANN ;ROHNER, ELIANE  (contact);WANDELER, GILLES

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;Adult;Adverse event;Affect;Africa;Africa South of the Sahara;African;Anti-Retroviral Agents;antiretroviral therapy;Breast Feeding;cancer care;cancer diagnosis;cancer health disparity;cancer prevention;cardiometabolic risk;Caring;cervical cancer prevention;Cervical Cancer Screening;Child;Clinical;co-infection;cohort;Collaborations;cost effective;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;data centers;Data Collection;data harmonization;Data Linkages;Databases;Devices;Diagnosis;Diagnostic;digital;Disease;Drug resistance;Drug resistance in tuberculosis;efavirenz;Epidemic;Epidemiology;epidemiology study;European;Evaluation;Funding;gender equity;genome sequencing;Goals;Health;Health care facility;health care settings;health data;Health Services;Health system;Hepatitis B;Hepatitis B Virus;HIV;HIV Seronegativity;HIV/AIDS;HIV/TB;implementation science;improved;improved outcome;in utero;Incidence;Individual;Infant;Infection;innovation;International;Joints;Leadership;Life Cycle Stages;Life Expectancy;Liver;low and middle-income countries;Lung Diseases;Malignant Neoplasms;mathematical model;Mental Health;Mentorship;Metabolic;Methods;Modeling;Monitor;mortality;new technology;novel;open data;Outcome;outcome disparities;Outcome Study;Output;Persons;Pharmaceutical Preparations;point of care;Policies;pre-exposure prophylaxis;Pregnant Women;Prevalence Study;prevent;Prevention;Prevention program;Prevention strategy;Private Sector;programs;Public Health;Pulmonary Tuberculosis;Quality of life;Regimen;Registries;Research;Research Personnel;resilience;Resistance;Risk;Risk Factors;Safety;SARS-CoV-2 transmission;screening;screening program;Sentinel;sequencing platform;Services;Sexually Transmitted Diseases;social;South Africa;South African;Southern Africa;Sputum;Statistical Models;substance use;Substance Use Disorder;Sustainable Development;targeted sequencing;therapy duration;Time;tool;Translating;transmission process;Treatment outcome;treatment program;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United Nations;United States;Universities;uptake;Viral;Woman;Work;World Health Organization;Youth

PROJECT_TITLE: International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: LUSAKA

ORG_COUNTRY: ZAMBIA

ORG_FIPS: ZA

ORG_NAME: UNIVERSITY OF ZAMBIA

PHR: Millions of persons with HIV in sub-Saharan Africa are now surviving for decades on treatment but are devel- oping chronic non-communicable disease complications that require new science and new directions in pre- vention, detection, and treatment. The University of Zambia (UNZA)-Vanderbilt HIV Research Training Partner- ship (UVP) has been extremely successful, achieving all its aims including supporting 11 UNZA PhD students, evaluating and facilitating a new structure for the UNZA PhD Program, and hosting two UNZA Visiting Faculty Scholars at Vanderbilt. We will deepen and extend the impact of UVP in catalyzing UNZA's research capacity by shifting the grant's primary leadership to UNZA, training five UNZA PhD students and four postdoctoral sci- entists, implementating UNZA's new postdoctoral fellowship program, adding two South-South partnerships with the University of the Witwatersrand and the Consortium for Advanced Research Training in Africa (CARTA), and establishing a Biostatistics Support Core service at UNZA.

PI_NAMEs: HEIMBURGER, DOUGLAS CORBETT;MUTALE, WILBROAD  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;antiretroviral therapy;Applications Grants;Career Choice;career development;Chronic;Clinical;Collaborations;comorbidity;Detection;Disease;Doctor of Philosophy;doctoral student;Ensure;Epidemiology;experience;Faculty;Fellowship;Funding;Goals;Grant;Growth;HIV;HIV therapy;implementation science;Individual;Infrastructure;innovation;Institution;Investigation;Investments;Leadership;Mentorship;Modeling;Nutritional Study;Output;Persons;post-doctoral training;Postdoctoral Fellow;Prevention;programs;Publications;Research;research and development;Research Ethics;Research Institute;Research Personnel;Research Training;Resource Development;sabbatical;Science;Scientist;Structure;Training;Training Programs;Universities;Visit;Writing;Zambia

PROJECT_TITLE: UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative There is a critical shortage of Academic Radiologists who are rigorously trained in Biomedical Imaging Research. These highly skilled and trained individuals are crucial to advance research in imaging and image-guided therapies, which will directly impact patient care. This new generation of Academic Radiologists will be essential to maximize the healthcare benefits that will come from interdisciplinary translational research linking advances in the sciences of genomics, proteomics and artificial intelligence with the ongoing technological evolution in Biomedical Imaging

PI_NAMEs: LINK, THOMAS M (contact)

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TERMS: biomedical imaging;Scientist

PROJECT_TITLE: Biomedical Imaging for Clinician Scientists


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Research to advance understanding of the development and progression of diseases and disabilities such as substance use and HIV that contribute to health disparities is a major goal of the National Institutes of Health's strategic research plan to reduce and ultimately eliminate health disparities. Innovative, evidence- based interventions that rely on well-researched and culturally-specific theories of human behavior are urgently needed to stem the rising tide of HIV and substance use. The Substance Use and HIV Prevention Research in Minority Communities research education and mentoring program aims to address this urgent research need through offering seed funding to promising clinical scientists to conduct applied research studies and a mentoring infrastructure to empower these scientists to successfully apply for and receive NIH funding to conduct rigorous, multiyear research projects in the communities most affected by the HIV and substance use epidemics.

PI_NAMEs: NEILANDS, TORSTEN BRIAN (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Applications Grants;Applied Research;Behavior;California;care outcomes;career;career development;Cell Nucleus;Clinical;Clinical Research;Collaborations;Communication;Communities;community research;Consultations;curriculum development;Data;Development;Development Plans;disability;Discipline;Disease Progression;Education;education research;Educational Curriculum;Elements;empowerment;Environment;Epidemic;ethnic minority;Evidence based intervention;experience;faculty mentor;feasibility research;Feedback;Fortification;Funding;gender minority;Goals;Grant;Health Disparities Research;health disparity;HIV;HIV/AIDS;Human;human capital;improved;Individual;Infrastructure;innovation;Joints;Link;Manuscripts;marginalized community;meetings;Mentors;Methods;minority communities;Minority Health Research;minority scientist;National Institute of Drug Abuse;NIH Office of AIDS Research;novel;Participant;peer;peer networks;Peer Review;Pilot Projects;Prevention;Prevention Research;Principal Investigator;professor;programs;Psychology;Public Health;Publications;racial minority;Reduce health disparities;Research;Research Personnel;Research Priority;Research Project Grants;research study;response;role model;San Francisco;Scientist;sexual minority;skills;social;social capital;Social Work;stem;structural determinants;Structure;substance use;success;symposium;theories;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Update;virtual;Visit;Vulnerable Populations;webinar;Work;Writing

PROJECT_TITLE: Substance Use and HIV Prevention Research in Minority Communities Training Program


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  Fenofibrate is the first oral drug ever with proven effects on diabetic retinopathy in type 2 diabetic patients by two independent clinical studies. This project will elucidate a new mechanism responsible for the therapeutic effect of fenofibrate on diabetic retinopathy. The studies will also identify the cGAS-STING pathway as a new drug target for the treatment of DR and are of clinical relevance.

PI_NAMEs: MA, JIAN-XING  (contact);TAKAHASHI, YUSUKE

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Ablation;Address;Adhesions;Agonist;Animal Model;Antiinflammatory Effect;Attenuated;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;Cells;Clinical Research;clinically relevant;Cyclic GMP;Data;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diabetic Retinopathy;Down-Regulation;Exposure to;Extravasation;Fenofibrate;Gene Activation;Genus Hippocampus;Human;immune activation;immunoregulation;Impairment;In Vitro;Inflammation;Inflammatory;inhibitor;Knockout Mice;Knowledge;Leukocytes;Leukostasis;Measures;Mediating;migration;Mitochondria;Mitochondrial DNA;mitochondrial genome;Modeling;monocyte;Mus;new therapeutic target;non-diabetic;novel;Oral;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Permeability;Phagocytosis;Pharmaceutical Preparations;Phosphorylation;Play;PPAR alpha;prospective;Regulation;Reporting;response;Retina;Retinal Diseases;Role;Signal Transduction;Stimulator of Interferon Genes;stressor;targeted treatment;Therapeutic Effect;Transfection;Transgenic Mice;Transgenic Organisms;Type 2 diabetic;Up-Regulation

PROJECT_TITLE: cGAS-STING signaling in diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

PHR: Project Narrative This project is relevant to human health because it is aimed at the discovery and characterization of novel compounds that interfere with the function of an essential enzyme present in malaria parasites, thereby generating information needed for the development of new antimalarial drugs. Moreover, the proposed project will fulfill the SuRE program’s core mission as it will enable the applicant to initiate and sustain a meritorious, multi-disciplinary drug design program that engages students from underrepresented minority groups.

PI_NAMEs: PAULA, STEFAN FRANZ (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Anti-malarials;Artemisinins;ATP phosphohydrolase;Binding Sites;Biological Assay;Biomedical Research;Ca(2+)-Transporting ATPase;Calcium;Chemicals;chemotherapy;Chloroquine;combat;Communicable Diseases;Communities;Complex;Computational Technique;Computing Methodologies;Culicidae;Dangerousness;Data;design;Development;Disease;Docking;drug candidate;Drug Design;drug development;Drug resistance;Drug Targeting;Education;Educational process of instructing;Effectiveness;Elements;Environment;Enzymatic Biochemistry;Enzyme Interaction;Enzymes;experimental study;fighting;Foundations;Future;Generations;global health;Goals;Group Meetings;Health;Homology Modeling;Human;Hydroquinones;Infection;inhibitor;innovation;Institution;interest;Ion Transport;Knowledge;Libraries;Life;Ligands;Malaria;Measures;Mediating;Membrane;Methods;Minority Groups;Mission;Modeling;Modification;Molecular;molecular dynamics;molecular modeling;multidisciplinary;Naphthoquinones;Nature;new therapeutic target;novel;novel therapeutics;Organic Synthesis;Parasites;Pharmaceutical Preparations;Physiological;Plasmodium;Plasmodium falciparum;Preventive;programs;Property;prototype;Publications;Quantitative Structure-Activity Relationship;Recombinants;Reporting;Research;Research Personnel;resistant strain;Role;Saccharomyces cerevisiae;scaffold;Site-Directed Mutagenesis;skills;small molecule;small molecule inhibitor;Structural Models;Structure;Structure-Activity Relationship;student participation;Students;symposium;Therapeutic Agents;tool;Training;transmission process;undergraduate research;undergraduate student;underrepresented minority student;vaccine development;Validation;Vendor;virtual

PROJECT_TITLE: Development of phenolic small molecule inhibitors of PfATP6, a Plasmodium calcium ATPase


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE A large majority of persons being treated for opioid use disorder with the medication methadone often experience chronic pain for which there are few effective treatments. This study will use a secure remote cellular box to manage take-home doses of methadone. We will examine whether splitting a dose of methadone into two smaller doses per day will manage both pain and opioid use disorder.

PI_NAMEs: ANTOINE, DENIS GODWIN (contact);DUNN, KELLY E

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Absence of pain sensation;acceptability and feasibility;Address;Adopted;Age;Analgesics;Bolus Infusion;Buprenorphine;Caring;chronic pain;chronic pain management;Clinic;clinically significant;comorbidity;Counseling;daily pain;Data;disability;Distress;Dose;Double-Blind Method;Drug Kinetics;Ecological momentary assessment;effective therapy;Electronics;Enrollment;experience;General Population;Goals;Grant;Home;Hour;human data;improved;Individual;Infrastructure;insight;Intervention;Intervention Trial;Laboratories;Maryland;Measures;Mental Depression;Methadone;methadone clinic/center;methadone treatment;Methods;Moods;operation;opioid treatment program;opioid use disorder;opioid withdrawal;Outcome;Pain;Pain interference;Pain management;Pain Measurement;pain reduction;Participant;patient subsets;Patients;Persons;Pharmaceutical Preparations;Phase;Placebo Control;Population;pre-clinical;Prevalence;primary outcome;Professional counselor;Provider;Public Health;Randomized;randomized, clinical trials;Recommendation;response;satisfaction;Schedule;Secure;Sensory;Severities;Sleep disturbances;standard of care;Structure;substance use;Testing;Training and Infrastructure;Treatment outcome;Visit

PROJECT_TITLE: Randomized Clinical Trial Intervention to Treat Chronic Pain Among Persons Maintained on Methadone for Opioid Use Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative The obesity epidemic presents an unprecedented challenge to the nation’s health systems, and existing gold standard behavioral weight loss treatments are highly expensive to implement due to their intensive, long-term nature and the highly trained clinicians required to deliver treatment. Approaches to decreasing costs (e.g., low intensity treatments, coaching by paraprofessionals rather than experts) have been implemented with moderate success, but weight losses are not consistent across different cost-saving approaches, suggesting that individuals may be best served when they are matched to the type of treatment they need, and when the resources matched to individuals are continuously adapted as their needs change. The primary goal of the proposed project is to evaluate the cost-effectiveness of an artificial intelligence (AI) system that continuously adjusts features of weight loss coaching including modality and coach skill level.

PI_NAMEs: LAFATA, ERICA M (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, VEERASAMY

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Accountability;Address;Adult;Affect;Algorithms;Alternative Therapies;American;Area;Artificial Intelligence;artificial intelligence algorithm;automated intervention;Automobile Driving;Behavior Therapy;Behavioral;Behavioral Research;Binge Eating;Body Weight decreased;Calories;care systems;Caring;Cellular Phone;Characteristics;clinically significant;cost;cost effective treatment;Cost Savings;Cost-Benefit Analysis;cost-effectiveness evaluation;Data;design;digital;digital data;effective therapy;Effectiveness;Expert Systems;Frequencies;Gender;Goals;Government;Health system;Hour;improved;improved outcome;Individual;Informal Social Control;innovation;Insurance;Intake;Internet;Intervention;Learning;learning progression;medication compliance;Mental Depression;Minority;Mobile Health Application;Modality;Modeling;Monitor;Motivation;Nature;Obesity;Obesity Epidemic;Outcome;Overweight;overweight adults;Pain management;Participant;Persons;Phase;Physical activity;Policies;Population;Professional counselor;programs;psychologic;Psychological reinforcement;Race;Randomized;recruit;remote delivery;Resource Allocation;Resources;responders and non-responders;response;Robotics;Sample Size;skills;success;System;Telephone;Testing;Text;Text Messaging;Time;Training;Treatment Efficacy;treatment responders;verbal;video chat;Weight;weight loss intervention;weight loss program;wireless

PROJECT_TITLE: Using Artificial Intelligence to Optimize Delivery of Weight Loss Treatment

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This T35 program is designed to develop in future physicians - at the end of their first year of medical school - an interest in, and hands-on appreciation of, biomedical research as a career and as a critical basis for better understanding the science that constitutes much of the medical literature and medical practice. Under supervision of a selected faculty member, some students, we expect, will be inspired by this experience to pursue careers in biomedical research; virtually all will be enabled to make better-informed decisions with respect to the practical applications of basic and clinical biomedical research, and to identify clinical problems that might be susceptible to basic or clinical research approaches.

PI_NAMEs: LEIBEL, RUDOLPH L (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Advisory Committees;Basic Science;Biomedical Research;Clinical;Clinical Sciences;college;Communication Programs;Databases;Dedications;experience;Faculty;faculty mentor;Fellowship;Funding;Goals;Grant;Hematology;Human Resources;Institution;interest;Manuscripts;Medical Students;member;Mentors;Monitor;National Heart, Lung, and Blood Institute;Participant;Physicians;programs;recruit;Reporting;Research;research faculty;Research Priority;Research Project Grants;response;responsible research conduct;Series;stem cell biology;Students;Suggestion;summer research;Surgeon;Surveys;Techniques;tool;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Wages;web platform;web portal;Writing

PROJECT_TITLE: Short Term Training Grant


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Alcohol abuse exacts a major toll on health and health costs in the United States and is the 3rd leading preventable cause of death in the U.S. There is no FDA-approved therapy for most forms of alcohol- induced organ injury such as alcoholic liver disease. Our focus on nutrition and alcohol-induced organ injury should lead to new therapeutic targets, new nutritional preventions/treatments, and improved mortality and morbidity.

PI_NAMEs: MCCLAIN, CRAIG J. (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Alcohol abuse;alcohol abuse therapy;alcohol exposure;alcohol intervention;alcohol research;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;base;Brain;Broccoli - dietary;Butyrates;Cause of Death;Chronic;cofactor;Collaborations;college;Communities;Country;Development;Dietary Fats;Dietary Intervention;Education;Enhancers;Epigenetic Process;Ethanol;exosome;Faculty;FDA approved;Feces;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fostering;Functional disorder;Funding;Future;Goals;Grant;gut bacteria;gut inflammation;gut-liver axis;Health;Health Care Costs;high school;Impairment;improved;Individual;Industry;Injury;Institution;Interdisciplinary Study;Intervention;intestinal barrier;Intestines;Knowledge;Lactobacillus;Lipids;liver inflammation;Mediating;Mediator;metabolome;metabolomics;Morbidity - disease rate;mortality;mouse model;multidisciplinary;nanoparticle;National Institute on Alcohol Abuse and Alcoholism;Neural Crest Cell;new therapeutic target;novel;nutrition;Nutritional;Organ;organ injury;Pathogenesis;prevent;Prevention;Prevention approach;Preventive;Probiotics;Productivity;Proteomics;Research;Research Personnel;Resources;Role;School Dentistry;Signal Transduction;Sulforaphane;teratogenesis;therapeutic effectiveness;Therapeutic Intervention;therapeutic target;United States;United States National Institutes of Health;Universities;Volatile Fatty Acids

PROJECT_TITLE: The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Nutrition;Substance Misuse

PROJECT_TERMS: Advisory Committees;Alcohol abuse;alcohol research;Alcohols;Area;Arts;Basic Science;Bioinformatics;Biometry;Budgets;Cancer Center;Clinical;Clinical Investigator;Collaborations;Communities;Consultations;Country;Development;Discipline of Nursing;Education;Engineering;Ensure;Epigenetic Process;Evaluation;Functional disorder;Grant;gut microbiota;Health Sciences;high school;Individual;innovation;interest;International;Intervention;intestinal barrier;Intestines;Lead;Leadership;medical schools;Medicine;member;metabolomics;multidisciplinary;novel;nutrition;Organ;organ injury;Preventive;programs;Proteomics;Public Health;Reporting;Research;Research Personnel;Research Proposals;Resources;Role;Sampling;Schools;Science;Social Work;Specialized Center;Standardization;Structure;System;Therapeutic Intervention;Time;Tissues;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Infants born preterm are exceptionally prone to life-threatening gut-associated pathology, most notably necrotizing enterocolitis. The neonatal gut presents unique challenges because mechanisms that shape mucosal immune development through host-microbe interactions are still largely unknown. I propose to fill the knowledge gaps regarding early life mucosal immune development and dysbiosis by addressing the relevance of sphingolipids, mainly sphingosine-1-phosphate, in directing this intricate relationship.

PI_NAMEs: RUSCONI, BRIGIDA AGNESE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Acceleration;Address;Adult;Advisory Committees;Affect;age related;Agonist;Animal Experiments;Animal Model;Animals;antagonist;Appointment;Atypical lymphocyte;bacterial community;Biochemistry;Bioinformatics;Biology;career;career development;Cell Proliferation;cell type;Cells;Ceramides;Chronic;cohort;Complement;cytokine;Data;Dendritic Cells;Development;Development Plans;Diagnosis;dysbiosis;Emigrant;Environment;Enzymes;Event;Exposure to;Faculty;Feces;feeding;Fluorescent in Situ Hybridization;Functional disorder;Germ-Free;Grant;gut bacteria;gut inflammation;gut microbiota;Gut Mucosa;host-microbe interactions;Human;Human body;human data;human microbiota;hypoxia neonatorum;Immune;Immunology;improved;in vivo;Individual;Infant;Inflammatory;Injury;Institution;Integration Host Factors;interest;Intestinal Diseases;Intestines;ITGAX gene;Knockout Mice;Knowledge;Lamina Propria;Lesion;Life;lymph nodes;Lymphocyte;Lymphocyte Function;lymphocyte trafficking;Lymphopenia;Manuscripts;Mass Spectrum Analysis;mature animal;Mature T-Lymphocyte;Mediating;Mentored Research Scientist Development Award;Mentors;Metabolism;metabolomics;microbial;microbial community;Microbiology;microbiota;migration;Modeling;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mucosal Immunity;mucosal microbiota;Mucous Membrane;Mus;Necrotizing Enterocolitis;Neonatal;neonatal mice;neonate;Newborn Infant;novel;Outcome;Pathology;Peripheral;pharmacologic;Phenotype;Population;Premature Infant;Preparation;prevent;Prevention strategy;Process;Production;Publishing;pup;receptor;Research;Research Personnel;residence;response;Role;secondary lymphoid organ;Shapes;Signal Transduction;Signaling Molecule;Site;skills;Small Intestines;Specimen;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stimulus;T-Lymphocyte;Testing;thymocyte;Thymus Gland;Time;Tissues;Training;Very Low Birth Weight Infant;Work;Writing

PROJECT_TITLE: S1P as regulator of neonatal mucosal immune development and injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Substance Misuse

PI_NAMEs: KIRPICH, IRINA A. (contact)

PROJECT_TERMS: Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Model;Attenuated;attenuation;Bacteria;Biological Response Modifiers;Chronic;cytokine;Cytokine Signaling;Data;Development;Diet;Dietary Fats;Dietary Fatty Acid;Dietary Supplementation;Disease Progression;Down-Regulation;Effectiveness;Engineering;Ethanol;exosome;Experimental Animal Model;FAT gene;FDA approved;FPR2 gene;Functional disorder;gut inflammation;gut-liver axis;Health;Heavy Drinking;Hepatic;Hepatocellular Damage;Homeostasis;Host Defense;Human;Immune;Immune response;Impairment;improved;In Vitro;in vivo evaluation;Individual;Inflammation;Inflammatory;intestinal barrier;Intestinal permeability;Intestines;Kentucky;Linoleic Acids;lipid mediator;Liver;liver inflammation;liver injury;Macrophage;Mediating;Mediator;Microbe;Modeling;Molecular;monocyte;Mus;nanoparticle;novel;novel therapeutic intervention;Nuclear;nutrition;Nutritional;organ injury;Organoids;Pathogenesis;Patients;peripheral blood;Phagocytosis;Phenotype;Plants;Plasma;Play;preclinical study;Production;Prognosis;receptor;repaired;Research;Resolution;Rodent;Role;Sampling;Severities;Severity of illness;Signal Transduction;Survivors;systemic inflammatory response;Technology;Testing;Therapeutic Agents;therapeutic effectiveness;tissue repair;Tissues;Transcript;Transgenic Organisms;Translating;Whole Blood

PROJECT_TITLE: Role of n3 PUFAs and inflammation-resolving lipid mediator, RvD1, in alcoholic liver disease