ORG_CITY: DURBAN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF KWAZULU-NATAL

PHR: The South African Research Ethics Training Initiative (SARETI) is the oldest and most established Africa-based Masters program in the field of health research ethics. The new SARETI PhD program equips African research ethics scholars with advanced theoretical, applied and leadership skills to improve health research systems in Africa, improve effectiveness and efficiency of ethics review systems, and maximize the social value of research in Africa through research ethics leadership and scholarship. Intensive on-site training and home-based research work, including attendance of the Johns Hopkins Intensive Global Bioethics Program, will be facilitated by our experienced local and international multidisciplinary faculty.

PI_NAMEs: KRUGER, MARIANA ;WASSENAAR, DOUGLAS R (contact)

PROJECT_TERMS: Achievement;Adult;Africa;African;Area;Bioethics;career development;cohort;Data Analyses;Doctor of Philosophy;Education;Educational workshop;Effectiveness;Ethical Issues;Ethicists;Ethics;experience;Faculty;Funding;Generations;Grant;Health;Home;improved;Institutional Review Boards;interest;International;Lead;Leadership;Mentors;Mentorship;Mission;multidisciplinary;multimodality;Process;programs;Publications;Qualifying;Research;Research Ethics;Research Methodology;Research Proposals;Running;Scholarship;Selection Criteria;Site;skills;Social Values;South African;Structure;Supervision;symposium;System;systems research;Training;United States National Institutes of Health;Universities;Visit;Writing

PROJECT_TITLE: South African Research Ethics Training Initiative (SARETI) Leadership Program


ADMINISTERING_IC: TW

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Emergency Care

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The program proposed here aims to strengthen the international research ethics training capacity in Kenya while also addressing the specific needs related to One Health research and emergency health research. As a collaboration between the University of Nairobi (UoN) and The Ohio State University (OSU), it will offer in-depth training and experiences in research ethics and integrity through establishing and running both a 1-year postgraduate diploma (PGD) and a 2-year MSc in One Health and Emergency Research Ethics (MOHERE) at UoN. It will also fund and mentor 6 future leaders in bioethics and research ethics to take the OSU MA in Bioethics so that together all these graduates will become leaders in a sustainable, rigorous and exciting culture of research ethics in Kenya.

PI_NAMEs: O'MATHUNA, DONAL  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Achievement;Address;Advisory Committees;Agriculture;Animals;Area;Bioethics;Bioethics Consultants;Collaborations;Committee Members;Competence;Complex;Consultations;Country;COVID-19;Development;Disasters;Disease Outbreaks;Education;Educational Activities;Educational process of instructing;Educational workshop;Emergency research;Emergency Situation;Ensure;Environment;Environmental Health;Ethical Issues;Ethics;experience;Feedback;Fostering;Funding;Future;global health;Goals;Government;Growth;Guidelines;Health;Health Professional;Human;human subject;improved;Institution;Institutional Ethics;interdisciplinary approach;International;Investments;Kenya;Knowledge;Leadership;Link;low and middle-income countries;Mentors;microbial;Monitor;multidisciplinary;next generation;Ohio;pandemic disease;Participant;Persons;Plants;Play;Policies;Post Graduate Year;Prevention;Process;programs;Protocols documentation;Regulation;Reporting;Research;Research Ethics;Research Personnel;Research Project Grants;response;Review Committee;Running;Scholarship;Scientist;skills;social;Surveys;System;Time;Training;Training and Education;Travel;Universities;Virus Diseases;webinar;Work

PROJECT_TITLE: UoN-OSU MSc in One Health and Emergency Research Ethics (MOHERE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The proposed research ethics and methods certificate program will have significant impact in the socio-cultural context of The Gambian people by building leadership and expert capacity. The program will enhance the professional growth of health professionals and academic researchers through the strengthening of competence to conduct health research studies with high ethical standards and scientific rigor. These activities will have long term impact in shaping the scientific enterprise and the culture of ethics in The Gambia to improve population health outcomes.

PI_NAMEs: NJIE-CARR, VERONICA P.S. (contact);SEY-SAWO, JAINABA ;SILVERMAN, HENRY J

PROJECT_TERMS: Adult;African;Applications Grants;apprenticeship;Attitude;Award;Awareness;Baltimore;certificate program;cohort;Collaborations;Committee Members;Competence;Consultations;curriculum development;Data Collection;design;Development;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Enrollment;Ensure;Ethics;Ethics Committees;experience;Faculty;falls;Fogarty International Center;Foundations;Funding;Future;Gambia;Ghana;Goals;graduate student;Grant;Growth;Health;Health Professional;Healthcare;Hybrids;improved;Institution;Institutional Review Boards;Knowledge;Leadership;low and middle-income countries;Maryland;member;Mentors;Modeling;Nigerian;Outcome;pedagogy;Performance;Persons;population health;Preparation;Program Development;programs;Qualifying;recruit;Research;Research Ethics;Research Methodology;Research Personnel;research study;response;Review Committee;Role;Shapes;skills;social culture;success;Surveys;Training;Training Programs;Universities;virtual

PROJECT_TITLE: Strengthening Capacity in Health Research Ethics and Methodology in The Gambia


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Kidney Disease;Lung;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ADDIS ABABA

ORG_COUNTRY: ETHIOPIA

ORG_FIPS: ET

ORG_NAME: ADDIS ABABA UNIVERSITY

PHR: PROJECT NARRATIVE The primary focus of the proposed research is air pollution, with sub-studies focused on exposure assessment and air pollution impacts on lung function, blood pressure, and cognitive development, as well as a study focused on occupational heat stress. The research will take place at three leading universities in East Africa: Addis Ababa University in Addis Ababa, Ethiopia; Makerere University in Kampala, Uganda, and University of Nairobi in Nairobi, Kenya. The portfolio of studies in the proposed research solidifies and expands work begun in the first funding cycle of the Eastern Africa GEOHealth Hub, and will provide excellent opportunities for the trainees at each institution, as described in the linked GEOHealth Research Training proposal.

PI_NAMEs: BERHANE, KIROS T;JACK, DARBY ;KUMIE, ABERA TAKELE (contact);SIMANE, BELAY

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Accounting;Address;adverse outcome;Africa;African;air monitoring;Air Pollution;air pollution control;ambient air pollution;Awareness;Blood Pressure;burden of illness;Capital;Cessation of life;Child;Child Health;Chronic Kidney Failure;Cities;climate change;cognitive development;cohort;Collaborations;Collection;Country;Data;Data Collection;development policy;disorder risk;Eastern Africa;Environment;Environmental Health;Environmental Illness;Environmental Monitoring;Environmental Policy;Epidemiology;epidemiology study;Ethiopia;evidence base;Exposure to;extreme heat;Face;fine particles;Foundations;Funding;global environment;Goals;Health;Heat Stress;Hospital Mortality;Household;Income;Inequity;Infrastructure;Injury;Institution;interest;Investments;Kenya;Link;low and middle-income countries;low income country;lung development;Measures;Mentors;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;Needs Assessment;Neurocognitive;Occupational;Occupational Exposure;Occupational Health;Pilot Projects;Policies;Population Characteristics;premature;Productivity;programs;Psychometrics;Public Health;pulmonary function;Records;Renal function;Reproductive Health;Request for Applications;Research;Research Design;Research Personnel;Research Training;Resolution;respiratory health;Respiratory Signs and Symptoms;response;Risk;Risk Factors;Sampling Studies;Series;Shapes;Site;Source;spatiotemporal;Structure;success;Testing;Time;Training;Training Programs;Translations;Uganda;Universities;Woman;women's reproductive health;Work;Workplace

PROJECT_TITLE: Global Environmental and Occupational Health Research and Training for Eastern Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The statistical and agent-based model tools developed through this project in urban Kenya will be widely applicable to studying multi-pathogen infectious disease transmission dynamics in low to middle income nations, and will address global needs for evidence to prioritize urban development interventions.

PI_NAMEs: BAKER, KELLY K;SEWELL, DANIEL  (contact)

PROJECT_TERMS: Accounting;Affect;Animals;Area;attributable risk;Behavior;Behavioral;Biological Assay;burden of illness;Caregivers;Cattle;Characteristics;Child;Communicable Diseases;Communities;Complex;Computer Models;Computer software;Computing Methodologies;Country;Data;Defecation;Demographer;design;Detection;Developing Countries;Development;Diarrhea;Diffusion;Disease;Disease Pathway;disease transmission;Domestic Animals;dynamic system;Economic Development;Economics;Ecosystem;effective intervention;Enteral;enteric infection;enteric pathogen;Environment;Epidemiologist;Evolution;experimental study;exposure pathway;Exposure to;Failure;Feces;Floor;Frequencies;gastrointestinal;Geography;Household;Human;improved;Incidence;Income;Individual;Infant;Infection;infection risk;Ingestion;Intervention;Joints;Kenya;large datasets;Latrine;Lead;Long-Term Effects;Low income;Mathematics;Measures;Methods;microbial;microbial community;Microbiology;Milk;model design;Modeling;Morbidity - disease rate;mortality;Movement;multi-scale modeling;Neighborhoods;open source;pathogen;Pathogenicity;Pathway interactions;Pattern;pediatrician;Policies;Pollution;Population Attributable Risks;Positioning Attribute;predictive modeling;Prevalence;prevent;Process;Research;Research Personnel;Risk;Sanitation;Scientist;Seasons;simulation environment;Site;social;Social Development;sociologist;Source;spatiotemporal;Statistical Methods;Statistical Models;stool sample;Structure;Surveys;System;Taxonomy;Testing;therapy development;tool;Training;transmission process;urban area;Urban Community;Urban Developments;urban setting;Urbanization;Viral;virtual laboratory;wasting;Water;Work

PROJECT_TITLE: Statistical and agent-based modeling of complex microbial systems: a means for..

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The area postrema, a brain circumventricular sensory organ regulated by both humoral signals and inputs from the gastrointestinal tract, plays a critical role in nausea and aversive behaviors. During my postdoctoral fellowship, I identified and characterized a population of area postrema neurons which mediates aversive behaviors, and here I will specify and map both humoral and vagal inputs to these area postrema neurons and understand their physiological effects. Acquiring expertise required to achieve these aims, namely hormone signaling and functional circuit mapping, will enable me to establish an independent research program which focuses on the cellular and neural mechanisms of nausea combining mice and vomiting animals, and may lead to the development of novel anti-emetic therapies.

PI_NAMEs: ZHANG, CHUCHU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Ablation;Adverse effects;Afferent Neurons;Anatomy;Animal Model;Animals;Anti-emetics;Atlases;Behavior;behavioral study;Biological Assay;Blood - brain barrier anatomy;Brain;cancer therapy;career;Cell Surface Receptors;cell type;Cells;Chemoreceptors;Communication;Cues;design;Development;Diabetes Mellitus;Educational process of instructing;Electrophysiology (science);Emetics;Esthesia;excitatory neuron;experimental study;Feeding behaviors;Fellowship;Food Poisoning;Gastrointestinal tract structure;GCG gene;GDF15 gene;Genetic;genetic signature;Genetic study;Goals;hormonal signals;Horns;Human;Hunger;Image;Imaging Techniques;In Vitro;Infection;Ingestion;inhibitory neuron;Knock-in Mouse;learned behavior;Learning;Lesion;Ligands;Location;Malaise;Malignant Neoplasms;Maps;Mediating;Mentors;Mentorship;Midbrain structure;Modeling;Molecular;Motion Sickness;Mus;Nausea;Nausea and Vomiting;neural;neuromechanism;Neurons;Neurosciences;novel;optogenetics;Organ;Orphan;parabrachial nucleus;pathogen;Peripheral;Phase;Physiological;Physiology;Play;Poison;Population;Positioning Attribute;Postdoctoral Fellow;Pregnancy;programs;receptor;Regulation;Research;response;Role;Route;Satiation;Sensory;sensory input;Shrews;side effect;Signal Transduction;single nucleus RNA-sequencing;skills;Specific qualifier value;Stimulus;Structure;Structure of area postrema;Techniques;Testing;Therapeutic;Thirst;Tissues;Toxin;Toxin Conjugates;Training;transcriptome;Viral;Visceral;Vocational Guidance;Vomiting

PROJECT_TITLE: Molecular and circuit mechanisms of nausea-associated behaviors


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Uterine serous carcinoma (USC) is associated with treatment resistance and a poor prognosis. Although several  molecular similarities exist between USC and serous ovarian cancer in terms of homologous recombination DNA  repair deficiency, responses of USC to single agent PARP inhibitors are limited. Here we propose to study a  novel combination therapy in an attempt to overcome treatment resistance.

PI_NAMEs: KAUFMANN, SCOTT H (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Carcinoma;Cell Line;Characteristics;Clinical;clinical development;Clinical Trials;Combined Modality Therapy;Complex;Data;design;DNA;DNA Damage;DNA Repair Disorder;DNA Repair Pathway;Endometrial Carcinoma;experience;experimental study;Formulation;Future;Genomic Instability;Histologic;homologous recombination;In Vitro;in vivo;inhibitor;innovation;irinotecan;Knowledge;Malignant neoplasm of ovary;Molecular;Mus;next generation;novel;novel marker;patient derived xenograft model;Patients;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;predicting response;Prognosis;Recurrence;response;response biomarker;Schedule;Serous;SN-38;synergism;targeted treatment;Testing;Therapeutic;therapy resistant;Time;TOP1 gene;Toxic effect;Translating;tumor;tumor xenograft;Uterus

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: This career development proposal leverages an expert multinational mentorship team and rigorous didactics to acquire essential skills for an independent global health research career. The research project addresses a critical knowledge gap, implementing and evaluating a home blood pressure monitoring intervention among women at risk of hypertensive disorders of pregnancy in Ghana. Expertise will be gained in survey questionnaire design, applied mixed methods, advanced quantitative methods, and reproductive health in Sub- saharan Africa.

PI_NAMEs: LAWRENCE, EMMA RACHEL (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: 2 arm randomized control trial;Address;Adherence;Adult;Africa South of the Sahara;arm;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;career;career development;Caring;Cellular Phone;Chronic;Clinic Visits;Clinical;Country;Data;Development Plans;Diagnosis;Discipline of obstetrics;Early Diagnosis;Eclampsia;Education;Effectiveness;effectiveness testing;Electronics;evidence base;Face;Frequencies;Ghana;global health;Goals;Gynecologist;Healthcare Systems;High Risk Woman;Home;Home Blood Pressure Monitoring;Hypertension;improved;Income;informant;innovation;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;low health literacy;maternal morbidity;Maternal Mortality;mathematical ability;Measures;Mentorship;Methodology;Methods;Michigan;Morbidity - disease rate;mortality;Neonatal;neonatal outcome;Nurses;Outcome;Paper;Participant;Patients;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Outcome;pregnant;Pregnant Women;prenatal;prevent;preventable death;primary outcome;Process;programs;Questionnaire Designs;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Reproductive Health;Research;research and development;Research Personnel;Research Project Grants;Resource-limited setting;Schedule;secondary outcome;Seizures;skills;Stroke;Structure;Surveys;Technology;Telephone;Time;Training;Triage;trial comparing;trial design;Universities;Visit;Woman;Women's Health

PROJECT_TITLE: Home blood pressure monitoring among women at risk of hypertensive disorders of pregnancy in Ghana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE We aim to adapt and pilot a guided self-help stress management program from the World Health Organization and to incorporate peer cancer survivors in providing psychosocial support to breast cancer patients in Viet Nam. We seek to demonstrate the feasibility of the culturally and contextually adapted intervention in reducing the psychological distress associated with cancer diagnosis and treatment, to ultimately improve cancer patients’ health outcomes. Successful completion of the project begins to fill the gaps in the lack of culturally appropriate evidence-based mental health interventions for cancer patients in many low- and middle-income countries, and in many racial/ethnic groups in the U.S.

PI_NAMEs: LE, PHUONGTHAO DINH (contact)

PROJECT_TERMS: Academic Training;Address;Adherence;Affect;anti-cancer research;Area;Behavior Therapy;Behavioral Sciences;Breast;Breast Cancer Patient;Breast Cancer survivor;cancer care;Cancer Center;Cancer Control;cancer diagnosis;Cancer Hospital;Cancer Intervention;Cancer Patient;cancer prevention;Cancer Survivor;cancer therapy;cancer type;care systems;career;career development;Caregivers;Cessation of life;Cities;clinically significant;Cognitive Therapy;Communities;community based participatory approach;community based participatory research;Community Health;coping;Country;design;Development;Diagnosis;Dimensions;Disease;Distress;Doctor of Philosophy;Effectiveness;Elements;Emotional;Ethnic Population;evidence base;Evidence based intervention;experience;Fellowship;Female Breast Carcinoma;flexibility;Focus Groups;Funding;Future;Goals;Health;health management;Health Personnel;Health Policy;Health Sciences;Health Services Research;Hospitals;Hour;implementation science;implementation strategy;improved;Incidence;Individual;informant;International;Intervention;Interview;Knowledge;Language;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;marginalized population;Mathematics;Medical;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Modification;multidisciplinary;National Cancer Institute;New York;Newly Diagnosed;Oncology;Outcome;Participant;participant observation;peer;peer coaching;peer support;Persons;Pilot Projects;Population;Postdoctoral Fellow;Prevalence;Prevention Guidelines;process evaluation;programs;psychologic;psychological distress;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Public Health;Qualitative Research;Quality of life;racial population;Recommendation;Reporting;Research;Research Activity;Research Assistant;residence;Resource-limited setting;Schools;Scientist;self help;Site;skills;Social Sciences;Social support;Specific qualifier value;stress management;Structure;Supportive care;Testing;Training;Training Activity;treatment guidelines;Universities;uptake;Vietnam;Vietnamese;Woman;working group;World Health Organization

PROJECT_TITLE: Adaptation and Pilot of a Peer-Facilitated Self-Help Plus Stress Management Intervention for Breast Cancer Patients in Viet Nam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Harmful menstrual practices, such as chhaupadi (menstrual seclusion) in Nepal, are an urgent threat to women’s health, wellbeing, and development. This study will investigate underlying mechanisms of promising aspects of chhaupadi interventions to date and build upon these findings to co-design and pilot test a context- specific intervention in partnership with community members. In the short-term, outcomes from this proposal will advance the field by resulting in 1) a pilot tested intervention that can be further tested in a future randomized controlled trial, 2) a refined approach for engaging communities in sustainable and contextually appropriate intervention co-design that is expected to be applicable to other low- and middle-income country contexts, and 3) in the longer-term support public health efforts aiming to reduce the negative health effects of harmful menstrual practices on women in Nepal.

PI_NAMEs: BAUMANN, SARA ELIZABETH (contact)

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Area;Attitude;Attitude to Health;Awareness;Behavior Therapy;behavioral health;Behavioral Model;career;career development;Cessation of life;Clinical Trials;Clinical Trials Design;Collaborations;Communities;community collaboration;community engaged approach;community engaged intervention;community engaged research;community engagement;Community Health;comparison control;Data;design;Development;Development Plans;Discrimination;Educational Curriculum;Educational Models;Educational workshop;Ensure;Environment;Evaluation;Exclusion;Failure;Family;Feedback;Focus Groups;Future;gender-based violence;girls;global health;Goals;Grant;Health;Health behavior;health knowledge;Health Sciences;human centered design;Human Rights;implementation science;improved;Individual;Infection;informant;innovation;International;Intervention;Intervention Studies;Interview;Leadership;Life;Literature;Loneliness;low and middle-income countries;meetings;member;Menstruation;Mental Health;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Nepal;Outcome;Participant;Personal Satisfaction;physical abuse;physical conditioning;Physiological Processes;pilot test;postnatal period;Process;professor;psychosocial;Public Health;Public Health Schools;Randomized;Randomized, Controlled Trials;Religion;Reporting;Reproductive Health;Research;research and development;Research Personnel;Resource-limited setting;Risk;role model;Safety;Schools;Self Efficacy;self esteem;skill acquisition;skills;Sleep;sleep difficulty;Snake Bites;social;social situation;social stigma;standardize measure;Statistical Data Interpretation;Stigmatization;success;Surveys;Testing;Theoretical model;therapy design;therapy development;Training;United States National Institutes of Health;Universities;Update;uptake;Validation;Woman;Women's Health;women's reproductive health;Work;Writing;Youth

PROJECT_TITLE: Improving Menstrual Health Among Women and Girls Using Community Engaged Intervention Development in Nepal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-P(55)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Sleep Research;Women's Health Research

PHR: PROJECT NARRATIVE Moderate to vigorous intensity physical activity is known to reduce the risk of hypertensive disorders of pregnancy and other adverse pregnancy outcomes that increase future maternal cardiovascular disease risk, yet less than 25% of pregnant women meet public health activity guidelines. More than 95% of the 24-hour day is spent in sedentary behavior, sleep, or light-intensity activity; however, the impacts of these lower intensity activities on adverse pregnancy outcomes are unknown. This multi-site observational cohort study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy and examine associations with adverse pregnancy outcomes to inform guidelines and future interventions designed to improve women’s pregnancy and long-term cardiovascular health.

PI_NAMEs: WHITAKER, KARA MARIE (contact)

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: actigraphy;Adverse event;adverse outcome;adverse pregnancy outcome;Affect;American Heart Association;Behavior;Behavior assessment;behavior test;Behavior Therapy;Behavioral;Blood Pressure;Blood Vessels;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Clinical;clinically relevant;Cohort Studies;Data;Data Analyses;demographics;Development;Devices;Diabetes Mellitus;early pregnancy;Event;Failure;Foundations;Future;General Population;Gestational Diabetes;glycemic control;Goals;Growth;Guidelines;Health;health difference;Hour;Hypertension;improved;Incidence;Intervention;Intervention Studies;Iowa;light intensity;Link;Maternal Health;Measures;Medical;Metabolic;Methods;Modeling;moderate-to-vigorous physical activity;modifiable behavior;Monitor;mortality;Mothers;National Heart, Lung, and Blood Institute;novel;Obesity;observational cohort study;Outcome;Patient Self-Report;Pattern;Physical activity;Pilot Projects;poor sleep;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Pregnancy Trimesters;Pregnant Women;Premature Birth;Prevalence;primary outcome;Public Health;recruit;Research;Research Priority;response;Risk;Risk Factors;Risk Reduction;Role;secondary outcome;sedentary lifestyle;Site;Sleep;sleep pattern;sleep quality;Small for Gestational Age Infant;Statistical Methods;Subgroup;success;therapy design;Time;Universities;vigorous intensity;Woman;women's outcomes

PROJECT_TITLE: Sedentary behavior, physical activity, sleep, and cardiovascular risk in pregnancy: the Pregnancy 24/7 cohort study

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Point-of Care tests (POCT) to rapidly and accurately diagnose infectious diseases including sexually transmitted infections (STIs) and other emerging and re-emerging infections will impact global public health and improve outcomes. Our goal is to accelerate the development of affordable POCT innovation.

PI_NAMEs: MANABE, YUKARI C (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acceleration;accurate diagnosis;Adoption;Algorithms;Antibiotics;biobank;Biological Assay;Clinical;clinical development;clinical encounter;Clinical Research;clinical research site;commercialization;communicable disease diagnosis;Communicable Diseases;Conscious;Consultations;cost;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 point of care;Data;Decision Making;Detection;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;diagnostic development;Diagnostic Equipment;diagnostic technologies;Diagnostic tests;disease diagnostic;emerging antimicrobial resistance;Emerging Communicable Diseases;Emerging infection;Engineering;Ensure;Environment;epidemic response;Evaluation;experience;FDA Emergency Use Authorization;Feedback;fitness;Funding;Goals;Health;Home;Human;Hybrids;improved outcome;In Vitro;Infection;innovation;Laboratories;Marketing;Modeling;Molecular;Molecular Target;multidisciplinary;Needs Assessment;overtreatment;Patient Recruitments;Patients;Performance;pilot test;Play;point of care;Point of Care Technology;point of care testing;point-of-care diagnostics;Positioning Attribute;pre-clinical;programs;prospective;Protocols documentation;prototype;Public Health;RADx Tech;rapid diagnosis;Recommendation;Research;research clinical testing;Resource-limited setting;Resources;Rest;Review Committee;Risk Factors;Sampling;self testing;Sexually Transmitted Diseases;success;Syndrome;targeted treatment;technological innovation;Technology;technology development;Test Result;Testing;Time;Training;Treatment Protocols;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Center for Innovative Diagnostics for Infectious Diseases


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE Poor cardiovascular health (CVH) contributes greatly to maternal morbidity and mortality in the United States, and many families enrolled in home visiting are at risk for poor CVH. Improving CVH requires focusing on CVH risk factors, 2-generation strategies addressing mothers and children, and greater use of settings where families already receive care. The Johns Hopkins Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Resource and Coordinating Center will generate rigorous, innovative, timely and actionable new knowledge to promote CVH and reduce CVH disparities in mothers and young children.

PI_NAMEs: COOPER, LISA A;EHRHARDT, STEPHAN ;MINKOVITZ, CYNTHIA S (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Applied Research;behavior test;Behavior Therapy;Biometry;Cardiovascular Diseases;cardiovascular health;care seeking;Caring;Child;Clinical;clinical center;clinical practice;clinical research site;clinical trial protocol;Clinical Trials;Communities;Data;Death Rate;design;Discipline of Nursing;Disparity;disparity reduction;dissemination science;early childhood;Early Intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Emerging Technologies;Enrollment;Epidemiology;Ethnic Origin;evidence base;Expectancy;experience;Family;forging;Funding;Generations;Geographic Locations;Geography;health disparity;health equity;health of the mother;Health Promotion;Heterogeneity;high risk;Home visitation;Implementation readiness;implementation science;implementation strategy;improved;Individual;Infant;Infrastructure;innovation;Intervention;intervention effect;Investments;Knowledge;Leadership;Life Cycle Stages;lifestyle intervention;maternal morbidity;Maternal Mortality;Mediator;Medicine;member;Methods;mHealth;Modeling;Morbidity - disease rate;mortality;Mothers;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;Obesity;Outcome Assessment;personalized approach;Policies;Preventive service;Primary Care;programs;Protocols documentation;Public Health;racial health disparity;Reduce health disparities;Reporting;Research;research and development;Research Design;Research Personnel;Resources;Risk;Risk Factors;Rural Community;scale up;service delivery;Services;Site;skills;Socioeconomic Status;Structure;success;Techniques;telehealth;Testing;Training;Translating;Translations;tribal community;United States;United States National Institutes of Health;Urban Community;Woman;Work

PROJECT_TITLE: Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite Resource and Coordinating Center


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Pain Research;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative  The proposed research will create a novel diagnostic tool for managing sickle cell disease based on a new high throughput cellular screening technology for evaluating red blood cells. There is currently no objective measure of vaso-occlusive crisis in sickle cell disease but the proposed technology will allow researchers and doctors to examine every single cell in a sample in a short amount of time using holographic images and machine learning. This technology can be used at the point of care to provide better information on the health of red blood cells for sickle cell disease patients.

PI_NAMEs: WAX, ADAM  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acute;Acute Pain;Affect;Africa;Africa South of the Sahara;African American;African American population;Algorithms;American;Analgesics;Archives;artificial intelligence algorithm;base;Behavior;Biological Assay;biophysical properties;Birth;Black American;Blood;Blood specimen;Bone Marrow Transplantation;Businesses;Cells;cellular imaging;Clinical;Clinical Research;Clinical Trials;clinically actionable;Complete Blood Count;Computer software;cost;cost efficient;Cytology;Cytometry;Data;data streams;Descriptor;design;Development;Devices;Diagnostic;diagnostic tool;Discrimination;Disease;Economic Burden;economic evaluation;Elements;Erythrocytes;Evaluation;experience;Family;field study;Goals;Hand;Health;Healthcare Systems;Hematological Disease;high throughput analysis;hologram;Holography;Image;imaging approach;imaging capabilities;Imaging Device;implementation cost;improved;Individual;Inherited;instrument;instrumentation;Laboratories;laboratory equipment;laptop;Lasers;Lighting;Machine Learning;machine learning algorithm;Measurement;Measures;Mechanics;Medical Device;Microfluidic Microchips;Microfluidics;Monitor;Morphology;Motion;new technology;Newborn Infant;novel diagnostics;novel strategies;novel therapeutic intervention;Optical Instrument;Outcome;Output;Pain;Pain Measurement;parallel computer;Patient Care;Patient Monitoring;Patients;Performance;Persons;Phase;Physiologic pulse;point of care;point-of-care diagnostics;Population;pressure;Procedures;Property;prototype;Pump;Research;Research Personnel;Resource-limited setting;Risk;Role;Sampling;screening;sensor;Severities;Severity of illness;Sickle Cell;Sickle Cell Anemia;Syringes;System;Systems Analysis;Technology;Testing;Therapeutic;Therapeutic Intervention;time use;tool;Translating;translational potential;vaso-occlusive crisis;Whole Blood;Work

PROJECT_TITLE: Point of care diagnostic for sickle cell disease


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed line of research is relevant to public health in that it represents a novel approach to postpartum management of preeclampsia. Once such an approach has been developed and tested, it would have broad implications for reducing maternal morbidity and improving disparities in postpartum hypertension care. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to reducing illness and disability through innovative research strategies.

PI_NAMEs: HAUSPURG, ALISSE  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adult;age group;antenatal;Anti-Hypertensive Agents;Antiinflammatory Effect;Aspirin;Attention;Award;Blood Pressure;blood pressure control;blood pressure reduction;Blood Vessels;Breast Feeding;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Career Mobility;Caring;Cause of Death;Chronic;Clinical;Clinical Trials;Data;Death Rate;design;Diagnosis;disability;disparities in morbidity;Disparity;disparity reduction;Dose;effective intervention;Eligibility Determination;Endothelium;Enrollment;Evaluation;evidence base;Evidence based intervention;experience;feasibility testing;Female of child bearing age;Funding;Future;Goals;Health;health care disparity;Home;Hypertension;hypertension control;improved;Individual;innovation;Intention;Intervention;intrapartum;Iontophoresis;Leadership;Link;maternal morbidity;Maternal Mortality;Measures;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Mission;Monitor;Morbidity - disease rate;novel;novel strategies;pathophysiology of preeclampsia;Pathway interactions;patient population;Pharmaceutical Preparations;pharmacologic;Phenotype;pilot test;pilot trial;Placebos;Population;post intervention;Postpartum Hypertension;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy health;prevent;Prevention;Primary Prevention;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;Research;Research Personnel;Risk;Risk Reduction;Role;Sample Size;Site;skill acquisition;Standardization;success;systemic inflammatory response;Testing;Therapeutic Agents;therapy development;Time;Translational Research;treatment as usual;treatment duration;treatment strategy;United States National Institutes of Health;Vascular Diseases;Vasodilation;Woman;Women's mortality;Work;young woman

PROJECT_TITLE: Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: COLUMBIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Vascular remodeling is process where vascular smooth muscle cells (SMC) transition from a differentiated phenotype to a proliferative state and plays a critical role in the development of diseases such as asthma, atherosclerosis, systemic hypertension and cancer. Here, we propose a combination of molecular, cellular and genetic approaches utilizing gain-of-function or loss-of-function studies to establish a novel mechanism regulating SMC phenotype modulation. Completion of this proposal will increase our understanding of mechanisms that contribute to the progression of proliferative vascular diseases and will result in the identification of a novel protein target to develop therapies to treat such diseases.

PI_NAMEs: KING, SKYLAR DAWN (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: alpha Actin;alveolar type II cell;Angioplasty;Animals;Arterial Disorder;Arteries;Asthma;Atherosclerosis;Attenuated;Blood Vessels;Bypass;Carotid Arteries;Cell Differentiation process;Cell Nucleus;Cell Proliferation;Cell Separation;Contractile Proteins;Data;Development;Diabetes Mellitus;Diabetic Angiopathies;Disease;Environment;extracellular;gain of function;Genes;genetic approach;Genetic Markers;Genetic Transcription;Goals;Histologic;Host Defense;human disease;hydrophilicity;Hyperplasia;In Vitro;in vivo;Inflammatory Response;Injury;Knock-out;Knockout Mice;Laboratories;loss of function;Lung;Malignant Neoplasms;Mechanics;Medial;Mediating;Mentors;Missouri;Modeling;Molecular;mouse model;mRNA Expression;Mus;MYH11 gene;myocardin;neointima formation;neutralizing antibody;novel;Operative Surgical Procedures;Pathogenesis;Phenotype;Phosphorylation;Physiological;Play;Process;promoter;Protein Secretion;Proteins;Pulmonary Surfactant-Associated Protein A;Rattus;Recombinants;restenosis;Role;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stents;Supplementation;Surface Tension;surfactant function;Systemic hypertension;targeted treatment;Testing;therapy development;Time;Tissues;Training;Transforming Growth Factor beta;Transplantation;Universities;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: The mechanistic role of surfactant protein A in smooth muscle cell phenotype modulation and vascular remodeling


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  Our proposal will be focused on increasing capacity in the Middle East and North Africa in environmental health research and especially with regards to climate change. There is a major gap in research capacity in this field despite the region is already suffering the health consequences of climate change in terms of increased frequency of heatwaves, desert dust storms, and drought and low frequency of precipitation. The hub will create the platform to expand and sustain this focus as the state-of-art go to entity in the region to help the populations and decisions makers address the climate change health impacts.

PI_NAMEs: ABDULLA, FAYEZ AHMAD;AL-DELAIMY, WAEL K (contact)

PROJECT_TERMS: Address;Air Pollution;Area;Awareness;California;Climate;climate change;climate impact;climate-related health;Collaborations;Communicable Diseases;Communities;Cost Effectiveness Analysis;dissemination science;Doctor of Philosophy;Droughts;Dust;Economic Models;Educational workshop;Environmental Health;Event;extreme weather;Floods;Grant;Health;Health Benefit;Health Policy;Health Sciences;Heat Waves;Human;implementation science;Individual;Institution;institutional capacity;Intervention;Jordan;Lebanon;Link;Local Government;Mental disorders;Mentors;Middle East;Morocco;Northern Africa;Planet Earth;Policies;Policy Maker;Pollution;Precipitation;programs;Research;Research Training;Risk;Science;symposium;Technology;Training;Training Programs;Universities;vector;virtual;Visit;water quality;webinar;Wildfire;Work

PROJECT_TITLE: 2/2 GeoHealth Hub for Climate Change and Health in the Middle East and North Africa-U.S.


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Dual-smoker couples (i.e., both members of a couple) are prevalent and treatment-resistant; they also confront unique challenges that may reduce the impact of standard treatments. The proposed randomized controlled trial systematically examines the efficacy, mechanisms, and cost effectiveness of implementing financial incentive treatments in this population. Support for the efficacy of dyadic financial incentive treatments for dual-smoker couples would be a scalable population-level intervention for a refractory subgroup of smokers.

PI_NAMEs: VANDELLEN, MICHELLE RENEE (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Address;Aftercare;behavior change;Biochemical;Categories;Characteristics;Cigarette;Clinical;clinical risk;Communication;contingency management;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Cotinine;Couples;Data;design;Effectiveness;efficacy evaluation;efficacy outcomes;efficacy testing;efficacy trial;Enrollment;Evidence based intervention;experience;Financial cost;financial incentive;Financial Support;follow-up;High Prevalence;high risk;improved outcome;Incentives;Individual;Intervention;long term abstinence;Maintenance;member;Motivation;nicotine replacement;Outcome;Outcome Study;Participant;Phase;Pilot Projects;pilot trial;Population;predicting response;Prevalence;Prognosis;Protocols documentation;psychoeducation;Randomized;Randomized, Controlled Trials;Refractory;Relapse;relative cost;Reporting;Research;Resistance;Resources;response;secondary endpoint;secondary outcome;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Smoking treatment;standard care;Subgroup;success;Target Populations;Testing;Time;treatment as usual;treatment comparison;treatment effect;treatment strategy;Underserved Population;Variant

PROJECT_TITLE: Randomized Controlled Trial of Dyadic Financial Incentive Treatment for Dual Smoker Couples: Evaluation of Efficacy, Mechanisms, and Cost Effectiveness

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE  People with schizophrenia are characterized by marked impairments in cognitive function, for which there are no current pharmacological treatments. The development of an effective intervention for cognitive impairments remains a major therapeutic challenge. Prebiotics are dietary fibers that promote the growth or activity of gut microorganisms, which leads to the enhanced well-being of the host. The proposed R61 and R33 projects are designed to evaluate the hypothesis that prebiotic administration will lead to increased production of butyrate, through increased activity of butyrate-producing bacteria in the gut microbiota; the increase in serum butyrate levels will be associated with changes in cognitive function, symptoms, and metabolic measures.

PI_NAMEs: BUCHANAN, ROBERT W (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acetates;Affect;Affective Symptoms;Aftercare;Attention;Bacteria;Behavior;Biological;Brain;Butyrates;Cholesterol;Chromatin Structure;Chromosome 6;Clinical;cognitive benefits;cognitive function;cognitive performance;cytokine;Data;design;Development;Dietary Fiber;Disease;Double-Blind Method;effective intervention;effective therapy;efficacy trial;Enzymes;executive function;Family;Fasting;functional outcomes;Gene Expression;Genetic Polymorphism;Glucose;Growth;gut bacteria;gut microbiome;gut microbiota;Histone Deacetylase Inhibitor;Immune system;immune system function;immunoregulation;Impaired cognition;Impairment;improved;Incidence;Inflammatory;interest;Intervention;intestinal barrier;Intestinal permeability;Inulin;Light;Lipids;MATRICS Consensus Cognitive Battery;Measures;Mediating;Memory;Metabolic;microbiota composition;Microglia;microorganism;Multiple Abnormalities;Neurocognitive Deficit;Nonpharmacologic Therapy;novel strategies;Nuclear;Outcome;Participant;Pathway interactions;Performance;Personal Satisfaction;Persons;pharmacologic;Pharmacological Treatment;Placebos;prebiotics;processing speed;Production;Propionates;psychiatric symptom;Randomized;randomized placebo-controlled clinical trial;receptor;recruit;Schizophrenia;Secondary to;Serum;Short-Term Memory;side effect;social cognition;Symptoms;Therapeutic;Triglycerides;Verbal Learning;visual learning;Volatile Fatty Acids

PROJECT_TITLE: Prebiotic Treatment in People with Schizophrenia

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_DEPT: PEDIATRICS

PHR: We have developed and clinically translated the combination of trabectedin and irinotecan as an EWS-FLI1 targeted therapy for Ewing sarcoma. While the clinical evaluation of this combination is promising and multiple tumor regressions have been observed, the activity has been limited by what appears to be intrinsic mechanisms of resistance. The goal of the current study is to exploit these mechanisms to develop novel EWS-FLI1 directed combination therapies with improved activity and less toxicity.

PI_NAMEs: GROHAR, PATRICK J (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: actinomycin;Binding;Biological Assay;Biology;Cell Nucleolus;Cell Nucleus;Cell Proliferation;Cell Survival;cell type;Cells;Chimeric Proteins;Chromatin;Chromatin Structure;Clinic;Clinical;Clinical Data;Clinical Trials;Combined Modality Therapy;Cytoprotection;Data;Dependence;Development;Disease;DNA;DNA Binding;DNA Binding Agent;DNA Damage;DNA Minor Groove Binding;Dose;Doxorubicin;driver mutation;Drug resistance;effective therapy;Enhancers;Epigenetic Process;epigenetic silencing;Etoposide;Ewings sarcoma;EWS-FLI1 fusion protein;EWSR1 gene;FLI1 Transcription Factor;Genes;Genetic Transcription;Genome;global run on sequencing;Goals;Heat-Shock Proteins 70;Impairment;improved;improved outcome;in vivo;inhibitor;insight;irinotecan;Malignant Neoplasms;Microsatellite Repeats;Modeling;Mutation;Normal Cell;novel;novel strategies;Nucleotides;Oncogenes;Oncogenic;Output;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase Transition;Poison;pre-clinical;Proteins;Proteomics;Recovery;recruit;Recurrence;Relapse;Reporting;research clinical testing;resistance mechanism;response;Response Elements;Site;success;targeted agent;targeted treatment;Testing;Therapeutic;Toxic effect;transcription factor;Translating;Treatment Efficacy;tumor;tumor growth;Ultraviolet Rays

PROJECT_TITLE: The interface of transcription, DNA damage and epigenetics: A therapeutic vulnerability of the EWS-FLI1 transcription factor

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

PHR: Hearing is important. Good hearing ability is an essential aspect of normal communication and plays an important role in safety and awareness in nearly every part of daily life.  Hearing trouble results in a myriad of difficulties, including communication trouble, difficulty at school or work, social isolation and/or stigmatization, potentially accelerated cognitive decline, and economic ramifications at the family, community, and national level.  Adults with hearing impairment are at risk for decreased quality of life, poorer health status, and diminished health care services received. Targeted interventions delivered in a community or medical setting, provided by audiologists, Ear, Nose, and Throat (ENT) doctors [aka, Otolaryngologists-Head and Neck surgeons], neuro-otologists, occupational and physical therapists, pediatricians, gerontologists, and other trained health care workers can potentially mitigate risks for long-term disability.   Hearing loss is a widespread problem. It is the third most common chronic physical condition in the United States and is twice as prevalent as diabetes or cancer.  Recent statistics indicate that 37.5 million U.S. adults aged 18 and older have some degree of hearing impairment.  Approximately 50 million Americans report tinnitus (ringing in the ears), a condition that can be as disabling as hearing loss.  Over 16 million of these individuals suffer frequent tinnitus, and about 2 million experience tinnitus so severe that it interferes with daily living activities.  Nationally, the total cost of first-year hearing loss treatment is projected to multiply five-fold between 2002 and 2030, from $8.2 billion to $51.4 billion. These NHANES epidemiological audiometric data will also provide national reference distributions – normative data – that can be used to screen for deficiencies across the U.S. population, and with the oversampling of minorities and other economically-disadvantaged individuals, it provides a barometer for disparities.   Most adult-onset hearing losses are permanent.  In the U.S., noise exposure is a major cause of preventable hearing loss.  Twenty-two million U.S. workers are exposed to noise annually, and 24% of hearing difficulty among workers is attributable to workplace noise exposure.  Noise-induced hearing loss (NIHL) is the second most commonly reported occupational disease and the most expensive disability for military and Federal workers’ compensation.  In recent years, some factors may have resulted in reduced loud noise exposure, such as better industry compliance with OSHA noise standards, implementation of noise-reducing innovations in the workplace, as well as the continuing shift of jobs away from manufacturing sector in the U.S. economy.  Noise does not just occur on-the-job; approximately 21 million adults have acquired a non-occupational NIHL.  Sources for non-occupational noise exposure include firearms use and many environmental or recreational exposures to loud music or noise, such as frequent attendance at loud sporting events and working with electrical tools or machinery.  As the Nation’s population ages and survival rates for infants and for people with severe injuries and acquired diseases improve, the prevalence of hearing loss and other communication disorders is expected to rise.

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adult;Affect;Age;Age Years;aged;Air;American;Area;Auditory Threshold;Awareness;Bilateral;Biological Assay;Blood;Carbon Monoxide;Chemical Exposure;Child;Chronic;cigarette smoking;Collaborations;Communication;Communication impairment;Communities;cost;Dancing;Data;Data Collection;Data Set;Devices;Diabetes Mellitus;digital;disability;Disabling;Disease;Disparity;Ear;Economically Deprived Population;Economics;Epidemiology;Ethnic Origin;Evaluation;Event;experience;Exposure to;External auditory canal;Family;Firearms;Frequencies;Future;Geographic Locations;Goals;Head and Neck Surgeon;Health;health care service;Health Personnel;Health Status;health training;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;Hearing Protection;Hearing Tests;Household;Hyperacusis;Impaired cognition;improved;Individual;Industry;Infant;innovation;Intervention;Interview;Laboratories;lead exposure;Life;Link;Long term disability;Loudness;Malignant Neoplasms;manufacture;Measures;Medical;Medical History;middle ear;Military Personnel;Minority;Monitor;Motorcycles;Movement;Music;National Health and Nutrition Examination Survey;National Institute for Occupational Safety and Health;National Institute on Deafness and Other Communication Disorders;Noise;noise exposure;Noise-Induced Hearing Loss;normal hearing;Nose;Occupational Diseases;Occupational Therapist;Occupations;Otolaryngologist;Otoscopes;Otoscopy;ototoxicity;Participant;Patient Self-Report;pediatrician;permanent hearing loss;Persons;Pharyngeal structure;Physical Examination;physical therapist;Play;Population;pressure;Prevalence;Prevention;Protective Devices;Protocols documentation;Pure-Tone Audiometry;Quality of life;Questionnaires;Race;Recording of previous events;Recreation;Reporting;Research;Research Personnel;response;Risk;Risk Factors;risk mitigation;Role;Safety;Sampling;Schools;Sensory;severe injury;sex;Social isolation;Socioeconomic Status;Solvents;sound;Source;Sports;statistics;Stigmatization;Surveys;Survival Rate;System;Testing;Tinnitus;tool;Tympanic membrane;Tympanometry;United States;United States National Center for Health Statistics;Work;Workers' Compensation;Workplace

PROJECT_TITLE: CDC-NCHS-NHANES Audiometry Component


ACTIVITY: ZIA

ADMINISTERING_IC: AG

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Prevention;Urologic Diseases

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: SIMONSICK, ELEANOR MARIE (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;age difference;age effect;age related;age related decline;Aging;aging process;aging related;Anatomy;Ancillary Study;Antioxidants;Autonomic nervous system;Baltimore;Biological;Blood;Blood Pressure;Body Weight;bone;Cardiovascular Physiology;Cells;Central Nervous System;Characteristics;Classification;Clinic;Clinical;Clinical Medicine;Clinical Research;Cognitive;cognitive function;cognitive performance;cohort;Cohort Studies;Collection;COVID-19;Data;data cleaning;Dedications;Dementia;design;Development;Diagnosis;disabled;Disease;DNA;DNA Methylation;Documentation;Elderly;Enrollment;Environment;Equilibrium;Equipment and supply inventories;Erythrocytes;experience;Feedback;Feeling;follow-up;frailty;Functional disorder;functional status;Future;gene environment interaction;General Population;Genetic;Genome Scan;Genomics;Genotype;Gerontology;glucose metabolism;Goals;hallmarks of aging;Health;Health behavior;Health Status;high risk;Home visitation;Homeostasis;Hormones;Hospitals;Human;human old age (65+);immune function;Impaired cognition;improved;Individual;inflammatory marker;insight;Intake;interdisciplinary approach;Intramural Research Program;Joints;Laboratories;Life;Life Cycle Stages;life span;Lipids;Longevity;Longitudinal Studies;Maintenance;Malignant neoplasm of prostate;Measurement;Measures;metabolomics;Mobility decline;Mobility disability;mortality;Muscle;muscle strength;Names;Nutritional;older adult;Older Population;Organ;Outcome;Outcome Measure;Oxidative Stress;pandemic impact;Participant;Pathologic Processes;pathological aging;Peripheral Nervous System;Personal Financing;Persons;Phenotype;Physical activity;Physical Function;Physiological;Physiology;Plasma;Process;Production;Prognosis;programs;prospective;prostate cancer risk;Proteomics;Publishing;Quality Control;Quality of life;recruit;Reference Standards;Reporting;Research;Research Personnel;Resources;SARS-CoV-2 exposure;Scientist;sensory system;Serum;Social Interaction;Societies;Specimen;Structure;study population;Surveys;Symptoms;System;Technology;Technology Assessment;Telephone;Time;Tissues;trait;trend;Uric Acid;Urine;Vaccination;Visit;volunteer;Work

PROJECT_TITLE: The Baltimore Longitudinal Study of Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: FERRUCCI, LUIGI  (contact)

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Baltimore;Behavioral;behavioral phenotyping;Biological Markers;Body Composition;Cognitive;cognitive ability;daily functioning;Data;Dementia;Early identification;Education;executive function;Exhibits;experience;Gait;Goals;Health;health data;high risk;high risk population;Individual;insight;Life Style;Longitudinal Studies;Memory;Memory Loss;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;metabolic profile;metabolomics;Motor;Nature;Neurobehavioral Manifestations;neuroimaging marker;novel marker;Participant;Performance;Persons;Phenotype;phenotypic biomarker;Process;Race;Sample Size;Sampling;Sampling Studies;Subgroup;Testing

PROJECT_TITLE: Metabolomic Signatures of Dual Cognitive and Gait Decline in relation to High Risk of Alzheimers disease in the Health ABC Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Amyloid deposition;Baltimore;Biological;Brain imaging;Cognitive;cognitive ability;cognitive function;cohort;daily functioning;Data;Development;experience;Gait;Goals;high risk;Impaired cognition;Individual;insight;Link;Longitudinal Studies;Lower Extremity;Manuscripts;Memory;Memory Loss;Meta-Analysis;Metabolic;metabolic profile;metabolomics;mild cognitive impairment;Motor;Nerve Degeneration;neuroimaging marker;Outcome;Performance;Phenotype;Physical Function;Plasma;pre-clinical;Process;Reporting;Sampling;Speed;Time

PROJECT_TITLE: Metabolomic signatures underlying cognitive and motor decline in the development of mild cognitive impairment and Alzheimer's disease


PROJECT_TERMS: Address;Age;Aging;Ancillary Study;Base Excision Repairs;Biological;Cancer Etiology;Cell Aging;Cell Cycle Arrest;Cells;Comparative Biology;Comparative Study;Consumption;coping;design;Development;DNA;DNA amplification;DNA Damage;DNA lesion;DNA redundancy;DNA Repair;DNA sequencing;Environmental Pollutants;Exposure to;Flow Cytometry;Free Radicals;Frequencies;genome sequencing;Genomic Instability;Goals;Growth Factor;hallmarks of aging;hormonal signals;Human;Individual;Induction of Apoptosis;Inflammation;Inflammatory;Innate Immune System;Invertebrates;Ionizing radiation;Lesion;Longevity;Maintenance;Mammals;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;monocyte;Mutation;Nonhomologous DNA End Joining;Nuclear;Nucleotide Excision Repair;Organism;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Phenotype;Predisposition;Quality Control;repaired;response;senescence;senescent cell;Somatic Mutation;Stress;Testing;Tissues;Ultraviolet Rays;Variant;whole genome

PROJECT_TITLE: The Hallmarks of Aging: Assessing accumulation of DNA lesions with age using single cell DNA sequencing in GESTALT


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Genetics;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: TIAN, QU  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;biobank;Brain;brain based;brain health;Brain Injuries;brain iron;Clinical Trials;Data;Data Correlations;Data Set;data submission;Dementia;Deposition;Development;Diagnostic;DNA copy number;follow-up;frailty;Free Radicals;genome sequencing;Goals;hallmarks of aging;Hemochromatosis;Homozygote;Human;Hydrogen Peroxide;Hydroxyl Radical;improved;Intramural Research Program;Iron;Iron Overload;Magnetic Resonance Imaging;Measures;men;mild cognitive impairment;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Motor;motor disorder;motor impairment;Mutation;novel;Oxidative Stress;Participant;Pathogenesis;Pathology;Pharmaceutical Preparations;prevent;Production;Prognostic Marker;Prospective cohort;Proxy;Reaction;Reactive Oxygen Species;reduced muscle strength;Research;Research Project Grants;Role;Testing;Whole Blood;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Understanding two novel factors related to motor impairment in the development of dementia - UK Biobank project (Alzheimer's disease concept)


PROJECT_TERMS: absorption;Acute;Adult;Affect;Atherosclerosis;Blood specimen;Cholesterol;cytokine;Data;Data Analyses;Data Collection;design;Diabetes Mellitus;Diet;dietary;Dietary Fats;Eating;Enrollment;fast food;Fatty acid glycerol esters;Food;fruits and vegetables;Glucose;Health;Heart Diseases;Hour;Individual;Inflammation;Inflammatory;inflammatory marker;Ingestion;Intake;intervention effect;Learning;Lipids;monounsaturated fat;Obesity;OGTT;Oxidative Stress;Persons;Reaction;Restaurants;Risk Factors;Sampling Studies;saturated fat;Saturated Fatty Acids;Source;Sterile coverings;Testing;Testosterone;United States;Unsaturated Fats;Unsaturated Fatty Acids

PROJECT_TITLE: Assessment of Post-Prandial Effects of a Fast-Food Meal on Inflammatory Markers


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine

PI_NAMEs: DING, JUN  (contact)

PROJECT_TERMS: Affect;Age;age effect;Aging;aging mechanism;aging process;aging related;Algorithmic Software;Algorithms;Alleles;Ally;Annual Reports;Baltimore;biobank;Biochemical;Biological;Biological Markers;Biological Process;Case/Control Studies;Cells;Chronology;cohort;Complex;computerized tools;Data;design;Disease;DNA;DNA Methylation;DNA Sequence;efficacy evaluation;Environmental Risk Factor;epigenetic aging;Fatty acid glycerol esters;Genes;Genetic;genetic analysis;Genetic study;Genome;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;Heritability;heteroplasmy;high throughput analysis;High-Throughput Nucleotide Sequencing;Individual;Leukocytes;Longitudinal Studies;machine learning method;Measures;Mediating;Mediation;Metabolic;Methods;Mitochondria;Mitochondrial DNA;mortality;mortality risk;National Heart, Lung, and Blood Institute;Nuclear;Participant;Personality;Personality inventories;Personality Traits;Phenotype;phenotypic data;Physiological;Population Control;Process;programs;Proxy;rate of aging;Risk;Sardinia;Single Nucleotide Polymorphism;Site;Speed;Statistical Algorithm;survival prediction;Telomerase;Testing;trait;Trans-Omics for Precision Medicine;Treatment Efficacy;Variant;whole genome;Work

PROJECT_TITLE: Statistical genetics of aging-related genomic and phenotypic change


PROJECT_TERMS: Age;age effect;age related;Aging;aging process;Area;Baltimore;bioinformatics resource;Biological;biological age;Body System;Bone Density;Candidate Disease Gene;Cardiovascular Diseases;Clinical;Cognition;cognitive function;cohort;Collaborations;cost;cost effective;Critical Pathways;Data;Dementia;Disease;disorder risk;DNA;early onset;endophenotype;Europe;Exclusion;expectation;falls;father role;Focus Groups;follow-up;Fracture;frailty;functional status;Funding;Gait speed;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genotype;hearing impairment;Human;Human Genome;human old age (65+);Incidence;inflammatory marker;insight;Insulin Resistance;Investments;Label;Laboratories;Life;Link;Literature;Longitudinal Studies;Measurement;Measures;Methods;muscle strength;Nature;neurogenetics;Osteoporosis;Outcome;Participant;Pathway interactions;Pattern;Phenotype;Physical Performance;Population;Prevention;prognostic assays;programs;Proteins;Proteomics;Public Health;Quality of life;rate of change;reference genome;Research Design;Resources;Risk;Sampling;Sampling Studies;sarcopenia;Serum;Staging;Structure;success;Testosterone;trait;United States;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: The Aging Genome Association Study "AGE-GAIN"


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Neurosciences;Nutrition;Physical Activity;Women's Health Research

PROJECT_TERMS: Address;Adult;Affect;age related deterioration;Aging;aging process;Anatomy;Antioxidants;Autonomic nervous system;Baltimore;Basal metabolic rate;Biological;Biological Markers;bone;Cell Respiration;Central Nervous System;Charge;Chronic;Chronic Disease;Clinical;Clinical Research;Cognitive;Collaborations;Complement;Data;Defect;Development;disability;Disease susceptibility;Elderly;Elements;Endocrine system;Energy Metabolism;Environment;Epidemiology;epidemiology study;Equilibrium;Etiology;Evolution;Feedback;frailty;free radical oxygen;Generations;Health;high throughput screening;Homeostasis;Hormones;Immune system;Impairment;improved;Inflammatory;Inflammatory Response;Institution;Intake;Joints;Longitudinal Studies;macromolecule;Measures;Methodology;Modeling;Morbidity - disease rate;mortality;Motivation;Motor;Muscle;Neurologic;Nutrient;nutrition;older adult;Older Population;Outcome;Oxidative Stress;Oxygen;Parasympathetic Nervous System;Pathway interactions;Performance;Peripheral Nervous System;Phase;Physical activity;Physiological;Process;Production;programs;Property;Reactive Oxygen Species;repaired;Research;Research Personnel;Sardinia;Scientist;Signal Transduction;somatosensory;Stress;Stressful Event;System;Testing;Women's Health

PROJECT_TITLE: Biomarkers of Homeostatic Dysregulation in Aging and Chronic Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease risk;case control;cohort;computational pipelines;Data;Data Set;Dementia;design;Disease;DNA;DNA copy number;Etiology;exome;Genetic;genetic approach;genetic association;Genome;genome wide association study;Goals;Haplotypes;Heritability;Individual;interest;Knowledge;Late Onset Alzheimer Disease;Link;Mitochondria;Mitochondrial DNA;mitochondrial genome;Neurodegenerative Disorders;Nuclear;preventive intervention;programs;prospective test;Public Domains;Research Personnel;Risk;Signal Transduction;Susceptibility Gene;Testing;trait;Variant;whole genome

PROJECT_TITLE: Assessing mitochondrial variation associated with Alzheimer's Disease


PROJECT_TERMS: Activities of Daily Living;Affect;age related;Aging;Architecture;Biomechanics;Correlation Studies;Development;disability;Disability prevention;epidemiology study;Fatty acid glycerol esters;Funding;Gene Expression;Gene Proteins;Goals;Impairment;Infiltration;Link;Longitudinal Studies;Measures;Metabolic;Microcirculation;Mitochondria;mortality;Muscle;muscle form;muscle strength;Muscular Atrophy;Older Population;Performance;preservation;Property;Publishing;reduced muscle strength;Research;Risk Factors;Sampling;Testing;Therapeutic;treatment strategy

PROJECT_TITLE: Changes in muscle biomechanical quality with aging: causes and consequences


PROJECT_TERMS: Age;age related changes;Age Years;Aging;aging biomarker;aging mechanism;aging process;Algorithms;Alternative Splicing;B-Lymphocytes;Biological;Biological Assay;Biological Markers;biomarker identification;Biopsy;Biotechnology;Blood Cells;Body Composition;CD8-Positive T-Lymphocytes;Cell Aging;cell type;Cells;Chromatin;Chronology;Code;Complex;Cues;cytokine;Data;Data Analyses;design;Dimensions;DNA Methylation;Endotoxins;Epigenetic Process;epigenome;Equation;experience;experimental study;Fibroblasts;Flow Cytometry;fly;follow-up;Functional disorder;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genomic Instability;Goals;hallmarks of aging;Homeostasis;Human;Immune;Inflammaging;Inflammation;Inflammatory;Interleukin-6;Laboratories;Longitudinal Studies;Lymphocyte;Manuscripts;Mass Spectrum Analysis;Measures;Memory;Messenger RNA;metabolome;Methylation;methylome;Microarray Analysis;Mind;Mitochondria;monocyte;Mus;Muscle;Neurons;next generation;NF-kappa B;Noise;Older Population;Organism;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Preparation;Process;Property;Protein Isoforms;Proteins;Proteome;Proteomics;Publications;Publishing;Reaction;Receptor Signaling;recruit;Reproducibility;Research;RNA Splicing;Sampling;Serum;Signal Transduction;Site;Skin;skin biopsy;stem;Testing;Tissues;TNF gene;trait;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Visit;Whole Blood;Yeasts

PROJECT_TITLE: GESTALT-Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Microbiome;Neurodegenerative;Neurosciences;Nutrition

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Actinobacteria class;Adult;Affect;Age;age related;Age Years;Aging;Alzheimer's Disease;Animals;Area;Bacteria;bacterial community;Bacteriodetes;Baltimore;beta diversity;Biological Factors;Biological Markers;Birth;Brain;brain health;Child;Cognition;cognitive function;Communities;Dentition;Development;Diet;dietary;Digestion;Disease;Ear;Elderly;Enrollment;Environmental Risk Factor;Epidemiology;Eukaryota;Firmicutes;follow-up;frailty;fungus;Gastrointestinal tract structure;Geographic Locations;glyoxylate;gut microbiome;gut-brain axis;Health;Health Status;Human;Human body;human data;Human Microbiome;human microbiota;Individual;Infant;Inflammatory;inter-individual variation;interest;Intestines;Investigation;life span;Location;Longitudinal Studies;men;metagenomic sequencing;Metagenomics;Microbe;microbial community;microbial composition;microbiome;microbiome composition;Mission;muscle strength;older adult;Oral cavity;Pathway interactions;Patients;Phenotype;Pilot Projects;Prokaryotic Cells;Reporting;Research;Resources;Role;Salivary;Sampling;Shotguns;Skin;Specimen;stool sample;Structure of nail of toe;targeted treatment;Technology;Time;trait;United States National Institutes of Health;Vagina;Virus;Visit;walking speed;whole genome;Woman

PROJECT_TITLE: Alzheimers Disease Project: Microbiome Projects in the Baltimore Longitudinal Study of Aging


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention

PROJECT_TERMS: Acceleration;Age;age group;aged;aging process;Biological;bone;Central Nervous System;Clinical;Clinical assessments;clinical examination;cohort;Cohort Studies;Collaborations;Data;disability;Disease;Elements;Enrollment;Epidemiology;Evaluation;Event;follow-up;Follow-Up Studies;functional loss;Funding;Goals;Health;Hospitalization;human old age (65+);Impairment;Intervention;Interview;Italy;Joints;Laboratories;Lead;Libraries;Measures;men;Muscle;Normal Range;Older Population;Participant;Performance;Peripheral Nervous System;Persons;Physiological;Population;Population Sciences;preventive intervention;Procedures;Production;Random Allocation;Registries;research clinical testing;Research Personnel;Risk Factors;rural area;Sampling;Site;System;Testing;Time;Update;urban area;Vital Status;Walking;walking performance;Woman

PROJECT_TITLE: The InChianti Study


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: SARTORELLI, VITTORIO  (contact)

PROJECT_TERMS: Adipocytes;Adult;Aging;Animal Model;Animals;Area;Atlases;Binding;Cell Differentiation process;Cell Lineage;Cells;Chondrocytes;Chromatin;chromatin modification;chromatin remodeling;Chromatin Structure;Complex;deep sequencing;Development;Enhancers;Enzymes;Epigenetic Process;Equilibrium;Gene Activation;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Transcription;Genome;Goals;histone methylation;histone modification;Histones;Homeostasis;Impairment;In Vitro;interest;Intervention;Knock-in Mouse;Knock-out;Maintenance;Mass Spectrum Analysis;Metabolic;metabolomics;Methyltransferase;Modification;Molecular;Muscle;muscle aging;Muscle Fibers;muscle progenitor cell;muscle regeneration;muscle repair;Muscular Dystrophies;myogenesis;Myogenin;Natural regeneration;Neurons;Nucleic Acid Regulatory Sequences;Pathologic;pharmacologic;Phenotype;Physiological;Polycomb;Process;Proliferating;Proteins;recruit;Repression;Research;skeletal;Skeletal Muscle;Skin;small molecule;Specific qualifier value;stem cell function;tissue culture;Totipotent Stem Cells;Transcription Coactivator;Transcriptional Activation;Transcriptional Regulation;Transgenic Organisms;Undifferentiated;Untranslated RNA

PROJECT_TITLE: Control of Adult and Aging Myogenesis


ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PROJECT_TERMS: Acetyltransferase;Actins;Adult;Aging;Animal Model;Animals;Atrophic;Biochemical;Breeding;Burn injury;Cell Culture System;Cells;Complex;Conceptions;Deacetylase;Denervation;Development;Dexamethasone;Elderly;Enterobacteria phage P1 Cre recombinase;EP300 gene;Epigenetic Process;Equilibrium;Euthanasia;experimental study;Exposure to;extend lifespan;Female;Fetus;Genetic Transcription;Goals;Harvest;healing;Heart;Histologic;Hormones;in vivo;Infusion procedures;injured;Injury;Kidney;Knock-out;knockout animal;Limb structure;Link;Liver;LoxP-flanked allele;Malignant Neoplasms;Measures;Metabolic;Modeling;Modification;Molecular;Molecular Analysis;Morphology;Mus;Muscle;Muscle Development;Muscle Fibers;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;muscular structure;Myoblasts;Natural regeneration;Nicotinamide adenine dinucleotide;novel;overexpression;Pancreas;Pathway interactions;PCAF gene;pharmacologic;Physiological;pregnant;premature;Process;promoter;Protein Biosynthesis;protein degradation;Proteins;reduced muscle mass;regenerative;Role;Saline;Sampling;sarcopenia;sciatic nerve;SIRT1 gene;skeletal;Skeletal Muscle;skeletal muscle differentiation;Skeletal Muscle Satellite Cells;skeletal muscle wasting;Spleen;Techniques;Therapeutic;Therapeutic Uses;Tissues;Transgenic Animals;Transgenic Mice;Traumatic injury;treatment strategy

PROJECT_TITLE: SIRT1 in Skeletal Muscle Development, Regeneration, and Atrophy


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lupus;Primary Health Care;Racial and Ethnic Minority Health Research;Rheumatoid Arthritis;Social Determinants of Health

PI_NAMEs: HASNI, SARFARAZ  (contact)

PROJECT_TERMS: Adult;Area;Arthritis;Assessment tool;Autoimmune;Autoimmune Diseases;barrier to care;Clinic;Clinical;cohort;Collection;Complementary and alternative medicine;COVID-19;Data;Dedications;Diagnosis;Disease;disease phenotype;District of Columbia;ethnic difference;ethnic minority;Evaluation;experience;Goals;health care disparity;health disparity;Immune;Improve Access;improved;indexing;Informed Consent;Intervention;Methods;metropolitan;minority communities;Minority Groups;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neighborhood Health Center;Observational Study;Outcome;Outcome Assessment;outreach;Patient Outcomes Assessments;Patient Self-Report;Patients;pediatric patients;primary care provider;Process;Research;Research Personnel;Research Support;response;Rheumatism;Rheumatoid Arthritis;Serology;Site;social health determinants;standard of care;Standardization;Symptoms;systemic autoimmunity;systemic inflammatory response;Systemic Lupus Erythematosus;Vaccines;Vascular Diseases;Viral;Washington;Yoga

PROJECT_TITLE: Rheumatic and Autoimmune Diseases in Minority Communities


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Rare Diseases

PI_NAMEs: KIM, HANNA  (contact)

PROJECT_TERMS: adaptive immunity;Adolescent;American;Animals;Arthritis;Autoantibodies;Biological;Biological Markers;Biological Models;cell type;Childhood;Chronic;Clinic;Clinical;Clinical assessments;Clinical Research;cohort;college;Complex;Controlled Study;disability;Disease;Double-Blind Method;Edema;Gene Expression;Genes;Goals;immune function;improved;Inflammation;Inflammatory;inhibitor;insight;interest;Interferon Type I;Interferon Type II;Interferons;Janus kinase;Juvenile Dermatomyositis;kinase inhibitor;Life;Magnetic Resonance Imaging;Measures;meetings;Morbidity - disease rate;Muscle;Myositis;Natural Immunity;novel;novel therapeutics;Organ;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patient Outcomes Assessments;Patients;Performance;peripheral blood;Pharmaceutical Preparations;Pilot Projects;Placebo Control;programs;protein biomarkers;protein expression;Protein Kinase;Refractory;Reporting;Research;research clinical testing;response;Rheumatology;Rhubarb food;Risk Factors;Role;Safety;safety assessment;Sampling;Serious Adverse Event;side effect;Signal Transduction;Skin;skin disorder;Subgroup;targeted treatment;Therapeutic;Tissue-Specific Gene Expression;translational medicine;translational study;treatment response;Urine;Vascular Diseases;Writing

PROJECT_TITLE: Juvenile Myositis Pathogenesis and Translational Medicine


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: KOVACS, JOSEPH A (contact)

PROJECT_TERMS: Adherence;Alveolar Cell;Animals;Antibodies;Antigens;Automobile Driving;B-Lymphocytes;beta-Glucans;Binding;Biological;Biological Assay;C-Type Lectins;Candida;Caspofungin;CD209 gene;CD3 Antigens;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cells;chemokine;chemokine receptor;Collaborations;CXCR6 gene;Cyst;cytokine;Defect;Dendritic Cells;Development;DNA Sequence Alteration;Endothelium;Enzymes;Epithelium;Exposure to;Flow Cytometry;fungus;glucan synthase;Glucans;Heterozygote;HIV Infections;Human;IL17 gene;Immune;Immune response;Immunocompetent;immunodeficiency;Immunodeficient Mouse;Impairment;improved;In Vitro;Infection;Infection Control;Inflammatory Response;Inhalation;inhibitor;Innate Immune Response;insight;Interferon Type II;Japanese;Kinetics;knock-down;Knockout Mice;Ligands;Lung;Lymphocyte;Macrophage;Mannans;mannose receptor;Masks;Membrane Glycoproteins;Membrane Proteins;Memory;Methods;Microarray Analysis;Modeling;mouse model;Mucin 1 protein;Mucous Membrane;Mus;novel strategies;Organism;pathogen;pathogenic fungus;Patients;Phenotype;Pneumocystis;Pneumocystis carinii;Pneumocystis carinii Pneumonia;Pneumocystis Infections;pneumocyte;Population;Predisposition;Production;programs;promoter;recruit;Regulatory T-Lymphocyte;Research Personnel;response;Riboflavin;Role;Signal Transduction;single-cell RNA sequencing;Structure of parenchyma of lung;Surface;T-Lymphocyte;Therapeutic;Time;TNFSF5 gene;transcription factor;Transfection;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Characterization Of Immune Responses During Pneumocystis Pneumonia


PI_NAMEs: DANNER, ROBERT L (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Acute;acute COVID-19;Acute Respiratory Distress Syndrome;Affect;Agonist;Aldosterone;alpha Tubulin;antagonist;apoAI regulatory protein-1;Apoptosis;Apoptotic;Arginine;arteriole;Atherosclerosis;Award;Back;bench to bedside;Biological Models;Biomedical Engineering;Blood;Blood Vessels;BMPR2 gene;Cardiogenic Shock;cardiometabolic risk;cardiovascular risk factor;Cardiovascular system;caveolin 1;Cells;Cessation of life;Chronic;Circulation;cohort;Complication;constriction;Coronavirus;COVID-19;COVID-19 complications;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cytoskeleton;Death Rate;dietary;Disease;Disease Progression;DNA Sequence;Drug Targeting;endothelial dysfunction;Endothelium;EP300 gene;ERCC3 gene;Event;Expression Profiling;Family member;Female;Festival;Fibroblasts;Fish Oils;Flow Cytometry;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Goals;Growth;Heart;heart preservation;hemodynamics;Hemoglobin;Hemostatic function;HIV;Human;IL8 gene;Immunochemistry;Impairment;In Vitro;indexing;Individual;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;inhibitor;Injury;Interferons;Interruption;Investigation;knock-down;Laboratory Study;Left;Link;loss of function;loss of function mutation;Lung;lung injury;lung vascular injury;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;MAPK8 gene;Mediating;Mediator;Mesenchymal;Messenger RNA;Meta-Analysis;Metabolism;Mitochondria;Modeling;Molecular Conformation;Monounsaturated Fatty Acids;mouse model;Multiple Organ Failure;Mus;Mutation;Myocardial Infarction;Natural History;NF-kappa B;Nitric Oxide;Nitric Oxide Signaling Pathway;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;NOS3 gene;NOTCH1 gene;Nuclear Receptors;Nucleic Acids;organ injury;Outcome;overexpression;Oxidants;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;phase 3 testing;Phenotype;Phosphorylation;PI3K/AKT;Pilot Projects;Play;Polyunsaturated Fatty Acids;PPAR gamma;Predisposition;Preparation;prevent;primary pulmonary hypertension;Procollagen-Proline Dioxygenase;Production;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;pulmonary arterial hypertension;Pulmonary Hypertension;Ras/Raf;Rattus;Reactive Oxygen Species;Receptor Signaling;Refractory;Relaxation;repaired;Repression;Research;Research Personnel;Resistance;right ventricular failure;Risk Factors;Role;rosiglitazone;Safety;Scleroderma;senescence;Sepsis;Septic Shock;Severe Acute Respiratory Syndrome;severe COVID-19;shear stress;Sickle Cell Anemia;Signal Pathway;Signal Transduction;Signal Transduction Pathway;small molecule inhibitor;Spironolactone;STAT1 gene;Stress;stroke risk;Structure of parenchyma of lung;symposium;System;Tertiary Protein Structure;Therapeutic;Therapeutic Intervention;thrombotic;TMPRSS2 gene;Transcript;Transcription Factor AP-1;transcription factor TFIIH;Translations;United States National Institutes of Health;vascular bed;Vascular Diseases;vascular inflammation;Vascular remodeling;Ventricular End-Diastolic Volumes;Viral Proteins;Virus;Vision;Work

PROJECT_TITLE: Vascular Dysfunction and Inflammation


PROJECT_TERMS: Animals;Biological;Biology;Canis familiaris;Centromere;ChIP-seq;Chitin;Chromosomal Rearrangement;Chromosomes;Collaborations;Communities;cross-species transmission;Data;Denmark;Development;Disease Outbreaks;DNA;Electrons;Environment;Epidemiology;Evolution;Family;Frequencies;fungus;Gene Family;Genes;Genetic Variation;Genome;genome sequencing;Genomic Segment;Genotype;Germany;Guanine + Cytosine Composition;Highly Active Antiretroviral Therapy;HIV;Human;Immunocompetent;immunodeficiency;Individual;Infection;Innate Immune Response;Introns;Kidney Transplantation;Lead;Link;Lower Organism;Lung;Mannose;Maps;Medical;medical schools;Membrane Glycoproteins;Methods;Minor;Mitochondria;mitochondrial genome;Molecular;Molecular Analysis;Mus;National Institute of Allergy and Infectious Disease;next generation sequencing;novel;Organism;Patients;Play;Pneumocystis;Pneumocystis carinii;Pneumocystis Infections;Population;Probability;prophylactic;Proteins;Rattus;Recording of previous events;Regimen;Reporting;Research Personnel;Resources;Rest;Restriction Fragment Length Polymorphism Analysis;Rodent;Role;Sampling;Scientist;Site;Source;Species Specificity;Structural Biologist;Surface Antigens;Switzerland;Synteny;Tandem Repeat Sequences;Techniques;therapeutic target;Time;transmission process;transplant centers;Transplant Recipients;Variant

PROJECT_TITLE: Molecular Studies Of Human and Rodent Pneumocystis


PI_NAMEs: STRONCEK, DAVID  (contact)

PROJECT_TERMS: B-Lymphocytes;Biological Assay;Cell Culture Techniques;Cell Physiology;Cell Therapy;Cells;cellular engineering;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical effectiveness;Complex;Dendritic Cells;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;Gene Expression Profiling;gene therapy;Genes;Genome;Hematologic Neoplasms;Hematopoietic stem cells;improved;Leukocytes;Measures;Messenger RNA;metabolomics;MicroRNAs;miRNA expression profiling;monocyte;next generation sequencing;novel;Outcome;peripheral blood;Production;single cell analysis;Site;sterility testing;T-Lymphocyte;Testing;Time;transcriptome;Transfusion;Unmarried person;vector

PROJECT_TITLE: Develop novel assays for assessing cellular and gene therapies


PROJECT_TERMS: Autoimmune Diseases;B-Cell Acute Lymphoblastic Leukemia;CAR T cell therapy;CD19 gene;CD22 gene;Cell Separation;Cell Therapy;Cells;cellular engineering;Characteristics;chimeric antigen receptor T cells;Clinical;Clinical Treatment;Deficiency Diseases;Dendritic Cell Therapy;Development;engineered T cells;Failure;gene therapy;Good Manufacturing Process;GPC3 gene;Hematologic Neoplasms;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune System Diseases;improved;induced pluripotent stem cell;instrument;Laboratories;Laboratory Research;Lymphoma;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;manufacture;Marrow;Methods;MS4A1 gene;novel;novel therapeutics;Oncoproteins;patient oriented;Patients;pediatric patients;Primary carcinoma of the liver cells;Procedures;Process;Production;Reagent;Regenerative Medicine;scale up;T-Cell Receptor;T-Lymphocyte;Tumor Antigens

PROJECT_TITLE: Development of novel cell and gene therapies


PROJECT_TERMS: 2019-nCoV;Acute;Adherence;Admission activity;Adrenal Cortex Hormones;aerosolized;Affect;Aldosterone;Algorithms;Allogenic;Alteplase;Animal Model;Animal Welfare;anthrax lethal factor;Anti-Inflammatory Agents;Antibiotic Therapy;Antibiotics;Anticoagulation;Aorta;Arginine;arm;attributable mortality;Blood;Blood Platelets;Blood Vessels;Bone Marrow Transplantation;Canis familiaris;Cardiac;cardiac repair;Cardiovascular Diseases;Cardiovascular system;Caring;Catecholamines;Ceftazidime;Cell Culture System;Cells;Cessation of life;Characteristics;Chest;Clindamycin;clinical investigation;Colistin;Communities;Comparative Effectiveness Research;comparative effectiveness trial;Comparison arm;Consent Forms;coronary event;Counterpulsation;COVID-19;Critical Care;Critical Illness;Data;Databases;Death Rate;Decision Making;design;Diagnosis;Diagnostic;Dose;drug resistant bacteria;Dryness;Early identification;Ebola;Edema;Elements;Endothelium;Endotoxemia;Endotoxins;Epidemiology;Epinephrine;Equilibrium;Escherichia coli;Etiology;Failure;Fibrinolysis;Functional disorder;Gene Expression;Glucocorticoids;Goals;healthcare burden;Heart;heart function;Heart Injuries;Hemoglobin;Heparin;Histopathology;Hospitalization;Hospitals;Hydrocortisone;Ibuprofen;Impairment;improved;improved outcome;Incidence;indexing;Infection;Inflammation;Informed Consent;Infusion procedures;Injury;innovation;Intensive Care;Interferons;Internships;Intravenous Immunoglobulins;Investigation;Investments;Ischemia;Journals;Left Ventricular Ejection Fraction;lethal factor;Levaquin;Liquid substance;lung injury;Measures;Meningoencephalitis;Mental Depression;Meta-Analysis;Mineralocorticoids;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Multiple Organ Failure;Mus;Myocardial dysfunction;Myocardial Infarction;Necrotizing fasciitis;new therapeutic target;Nitric Oxide;Nitric Oxide Synthetase Inhibitor;Organ;Outcome;Oxygen;p38 Mitogen Activated Protein Kinase;pandemic disease;pathogen;Patient Selection;Patients;Perfusion;Pneumonia;Population;pre-clinical;Prevention;procalcitonin;prophylactic;Public Health;Published Comment;Pulmonary Embolism;Rattus;reparative process;Research Subjects;Resistance;response;Risk;senescence;Sepsis;Septic Shock;severe COVID-19;severe injury;Severity of illness;Shock;Staphylococcal Enterotoxin B;Stem cell transplant;Stenotrophomonas maltophilia;Streptococcal Infections;Stroke;Supportive care;Syndrome;Therapeutic;Thrombus;tigecycline;Toxin;toxoplasmic encephalitis;Tracer;Transfusion;Transplant Recipients;Trauma;treatment as usual;trial design;Trimethoprim-Sulfamethoxazole;Update;Variant;Vascular Diseases;Vasoconstrictor Agents;volunteer

PROJECT_TITLE: Preclinical and Clinical Investigations of Severe Infection and Critical Illness


PROJECT_TERMS: anti-PD1 antibodies;Anti-Retroviral Agents;antiretroviral therapy;arm;Biological;Biological Markers;biomarker panel;Biopsy Specimen;C-reactive protein;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cells;Central Nervous System Diseases;Characteristics;Chronic;Clinical;clinically relevant;co-infection;Coagulation Process;cohort;Collaborations;Correlation Studies;COVID-19 pandemic effects;Cross-Sectional Studies;CXCL10 gene;CYP3A4 gene;cytokine;Data;design;Development;Diabetes Mellitus;Diagnosis;Disease;Dose;Drug Interactions;Drug Kinetics;drug metabolism;Eating;efavirenz;Endothelium;Enrollment;Enzymes;Evaluation;exome sequencing;Fibrin fragment D;Fibrosis;Flow Cytometry;flu;Genetic Markers;Genetic Transcription;Goals;Guidelines;healthy volunteer;Heart Diseases;Hepatitis B;Hepatitis C;Hepatitis C co-infection;Hepatitis C virus;Hepatotoxicity;histopathological examination;Histopathology;HIV;HIV Infections;Immune;Immune response;Immunologics;Immunophenotyping;improved;Infection;Inflammation;insight;Interferon Type II;Interleukin-6;Intervention;Kidney Diseases;Leptin;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Lung;Malignant Neoplasms;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;metabolic rate;Methods;Microscopic;monocyte;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nature;Nucleotides;Opportunistic Infections;participant enrollment;Pathogenesis;pathogenic virus;Pathway interactions;patient subsets;Patients;pembrolizumab;Pharmaceutical Preparations;Pharmacy facility;Phase;Pilot Projects;placebo controlled trial;platelet function;Predictive Value;premature;Prevalence;prevent;primary endpoint;Process;programmed cell death protein 1;Prophylactic treatment;Protocols documentation;Quality of life;recruit;Reporting;Research Personnel;responders and non-responders;Reverse Transcriptase Inhibitors;rifapentine;Risk;Safety;Series;Severities;single-cell RNA sequencing;Steatohepatitis;Symptoms;System;T-cell receptor repertoire;Tenofovir;Time;TNF gene;Transaminases;Tuberculosis;Viral Load result;Viremia;Virus;volunteer;von Willebrand Factor;Weight Gain

PROJECT_TITLE: Evaluation of HIV-related Complications


PI_NAMEs: SUFFREDINI, ANTHONY F. (contact)

PROJECT_TERMS: Acute;Adjuvant;Adrenal Cortex Hormones;Alveolar Macrophages;American;Anti-sense RNA;Apoptosis;Archives;arm;Bacteria;Biological Markers;Biological Process;Biological Response Modifiers;Blood;Blood Cells;Bronchoalveolar Lavage;Bronchoscopy;Bronchoscopy with Bronchoalveolar Lavage;Caring;Cell Communication;Cell Culture Techniques;Cell Death;Cell Physiology;Cell surface;Cell Survival;cell type;Cells;Cellularity;chemokine;Chemotaxis;Chest;Code;cohort;Communication;cytokine;Cytokine Signaling;Data;Dependence;design;differential expression;Disease;Distant;Eligibility Determination;Endotoxins;Enrollment;extracellular;Flow Cytometry;Functional disorder;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Gram-Negative Bacteria;granulocyte;Growth;healthy volunteer;Hour;Human;human model;immune function;Immune signaling;Immunophenotyping;Immunotherapy;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Intercellular adhesion molecule 1;intercellular communication;Interleukins;International;Intervention;Lung;Lymphocyte;Lymphocyte Subset;Macrophage;Malignant Neoplasms;Mediating;Membrane;microbial;MicroRNAs;migration;Modeling;Molecular;monocyte;Movement;neutrophil;next generation sequencing;Organ;pandemic disease;Pathway interactions;pharmacologic;Post-Transcriptional Regulation;prevent;Production;Proliferating;Proteins;Pulmonary Challenge;Pulmonary Inflammation;Regulation;Reporter;Research;Resolution;response;RNA;Role;screening;Signal Pathway;Signal Transduction;Societies;Stimulus;symposium;Time;tissue injury;TNF gene;Toll-like receptors;Transcript;transcriptome;transcriptome sequencing;Untranslated RNA

PROJECT_TITLE: Pulmonary Effects of Bronchial Segmental Endotoxin Instillation in Humans