NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative In 2019, Alzheimer’s and other dementias cost the U.S. $290 billion, and these costs could rise to as high as $1.1 trillion by 2050, which increases the urgency of developing new therapies to prevent, defer, slow the progression or improve the symptoms of these disorders using innovative clinical and basic research approaches. The goal of this project is to identify novel peripheral-central neuro-immune interactome-mediated sex differences that will assist in the development of clinically relevant preventive and therapeutic strategies to reduce the morbidity and mortality of AD. The successful completion of this project will advance the understanding of sex differences in AD and serve as the foundation for further translational studies to inform the development of precision medicine in a sex-specific manner.

PI_NAMEs: CHENG, FEIXIONG  (contact);LATHIA, JUSTIN D.

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Architecture;ATAC-seq;Basic Science;Biological Assay;Blood;Brain;brain tissue;care costs;Cause of Death;Cell Nucleus;cell type;Cells;chemokine;clinical development;Clinical Research;clinically actionable;clinically relevant;Cognitive;cohort;cost;cost of dementia;CX3CL1 gene;cytokine;Data;Data Analyses;Dementia;Development;Diagnosis;differential expression;Disease;Disease Progression;endophenotype;Enhancers;epidemiology study;Epigenetic Process;epigenome;epigenomics;Evaluation;Female;Foundations;Freezing;functional genomics;Funding;Future;Gene Expression;gene regulatory network;Genes;Genetic;genetic signature;Genetic Transcription;genomic data;genomic locus;Genomics;glial activation;Goals;Heterogeneity;Human;human data;human interactome;human subject;IL7 gene;Immune;Immune system;Immunology;Immunomodulators;improved;Incidence;Individual;individualized medicine;Infiltration;Inflammation;Inflammatory;innovation;insight;Interleukin-6;Interleukin-9;Machine Learning;male;Mediating;Microglia;mild cognitive impairment;Molecular;molecular targeted therapies;Morbidity - disease rate;mortality;multimodality;Myeloid-derived suppressor cells;National Institute on Aging;Nervous System Disorder;Network-based;Neuroglia;Neuroimmune;neuropathology;next generation;novel;novel therapeutics;Outcome;overexpression;Pathogenesis;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Play;Population Heterogeneity;precision medicine;Predisposition;prenatal;Prevalence;prevent;Preventive;Prognosis;promoter;protein expression;Reporting;Research;Role;Sampling;sex;Sex Differences;sexual dimorphism;single cell analysis;single cell genomics;single nucleus RNA-sequencing;symptomatic improvement;System;systemic inflammatory response;Systems Biology;Technology;Testing;Therapeutic;therapeutic development;therapy development;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transforming Growth Factor alpha;translational study;treatment response;United States;Variant;Woman;women patients;women versus men

PROJECT_TITLE: Microglial Activation and Inflammatory Endophenotypes Underlying Sex Differences of Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(52)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Programs that engage and sustain interest in science, health professions and cancer research among American Indian and Alaska Native (AI/AN) students and their teachers from middle school through college are desperately needed. With an experienced team, cutting-edge campus resources and strong partnership support, the Youth Enjoy Science program will continue to build community trust and recruit participants through outreach, train participants through research experiences, and develop and implement Indigenous science and cancer education curriculum and career development activities. Our aim is to not only increase AI/AN representation in cancer-related health professions and research but also advance the health of AI/ANs through improvements in cancer prevention, treatment, and research in AI/AN communities.

PI_NAMEs: GODFREY, MAURICE ;IDOATE, REGINA EMILY (contact);SOLHEIM, JOYCE C

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Administrator;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Arizona;Awareness;Basic Cancer Research;Biology;Cancer Center;Cancer Control;cancer education;cancer prevention;career;career development;Collaborations;college;Communication;Communities;community building;community engagement;community partners;community partnership;Consultations;curriculum development;Development;Education;Education and Outreach;education resources;Educational Curriculum;Educational Status;Educational workshop;Electronics;Elements;Ensure;Evaluation;Event;evidence base;experience;Exposure to;Faculty Workshop;Feedback;Fostering;Frequencies;Goals;Grant;Health;Health Occupations;Health Sciences;High School Student;Humanities;implementation facilitation;improved;Indigenous;Infrastructure;innovation;Instruction;interest;Internships;junior high school;Knowledge;Laboratories;Learning;learning materials;literate;Malignant Neoplasms;Measures;Medical;Medical center;Medicine;meetings;member;Mentors;Modeling;Native American population;Native Americans;Native-Born;Nebraska;Next Generation Science Standards;novel;Online Systems;Outcome;outreach;Ownership;Participant;Pathway interactions;Patient Recruitments;Peer Review;Persons;process evaluation;Program Development;program dissemination;Program Evaluation;programs;Publications;Readiness;recruit;Relationship-Building;Research;Resources;Rural;scale up;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;Services;Site;sixth grade;South Dakota;stakeholder perspectives;STEM research;Strategic Planning;student mentoring;Students;success;summer research;Surveys;symposium;System;teacher;Technology;Testing;tool;Training;translational cancer research;tribal community;Tribal School;Tribes;Trust;undergraduate student;Universities;urban Native American;virtual;Work;Youth

PROJECT_TITLE: Ignite-Engage-Sustain: A Comprehensive Approach to Motivate, Involve, Educate, and Mentor Native American Students and Their Communities in Cancer Prevention, Treatment and Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: ROC narrative HIV treatment and prevention in Rakai have led to dramatic declines in orphanhood. Measuring and understanding the relationship between HIV treatment and prevention, orphanhood, and new HIV infection among AYA will be essential in guiding future HIV prevention and social policies to promote child, adolescent, and young adult health. The ROC (Rakai Orphans in Communities) project will apply innovative qualitative and quantitative methods to broaden understanding of the impact of declining orphanhood on youth risk of HIV infection.

PI_NAMEs: SANTELLI, JOHN S. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent HIV risk;Adult;adverse outcome;Africa;Africa South of the Sahara;Age;AIDS prevention;antiretroviral therapy;Area;Attention;Behavioral;burden of illness;Child;Child Health;Cohort Studies;Communities;cost;Cost-Benefit Analysis;Data;Distal;Economic Factors;economic impact;Economics;Education;Educational Status;Epidemic;Event;Extended Family;Family;Family health status;Funding;Future;Health;Health Policy;HIV;HIV Infections;HIV risk;Household;improved;Incidence;Individual;infection risk;Information Systems;innovation;Interview;Investments;life history;male;Male Circumcision;Marriage;Measurement;Measures;Mediating;Medical;Mental Health;Methods;mortality;Occupations;Orphan;Parents;Perinatal;Policies;Population;Poverty;prevent;Prevention;Prevention program;programs;Reporting;Resource-limited setting;Resources;Risk;Risk Behaviors;Risk Factors;Role;Route;Secondary Schools;sex;social;Social Environment;social factors;social health determinants;Social Impacts;Social outcome;Social Policies;Socioeconomic Status;South Africa;Time;transmission process;treatment program;Uganda;United States National Institutes of Health;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Rakai Orphans in Communities


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This study will identify policies with the greatest potential to buffer people who use drugs from the adverse effects of this pandemic and future societal crises. The study will also provide insights on the types of communities that are most vulnerable to the effects of disasters on overdose. This knowledge can help improve and optimally target public policy responses to future pandemics and other major disasters.

PI_NAMEs: CERDA, MAGDALENA  (contact);FRIEDMAN, SAMUEL R

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Adoption;Adverse drug effect;Affect;aged;Black Populations;Black race;Buffers;Cessation of life;Characteristics;climate change;cohort;Communities;Conflict (Psychology);Consumption;Containment;Country;County;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;Death Rate;Diagnosis;Disasters;drug market;Drug usage;Drug user;Economic Policy;Economically Deprived Population;Economics;Ethnic Origin;Event;experience;Fentanyl;Future;future pandemic;Harm Reduction;Health;Health Services;Health Services Accessibility;Heterogeneity;Hispanic Populations;Home;Hospitalization;Housing;improved;Incidence;Income;Individual;Inequality;Inequity;insight;Investigation;Knowledge;long term COVID-19 pandemic impacts;man;mass shooting;Measures;Mediating;Medicaid;Methadone;Modeling;Naloxone;Natural Disasters;opioid use disorder;Outcome;Overdose;overdose risk;pandemic disease;pandemic impact;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Policies;Politics;Population;Poverty;Prevalence;prevent;Prevention;programs;Public Health;Public Policy;Race;Relapse;Research;Research Design;residential segregation;response;Risk;Role;SARS-CoV-2 infection;Services;social;social disparities;Social isolation;Social Policies;Source;Structure;Subgroup;Testing;theories;Unemployment;Urban Community;Vulnerable Populations;Wages;waiver;Wing;Workplace

PROJECT_TITLE: Understanding the short- and long-term effects of the COVID-19 pandemic on the overdose crisis


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE The L.S. Skaggs Institute for Health Innovation (SIHI) Research Evaluation and Commercialization Hub (SIHI- REACH) at the University of Montana will accelerate translation of academic discoveries into products that impact human health in states that have largely not benefitted from investment in commercialization. We have partnered with 10 academic institutions in the Washington, Wyoming, Alaska, Montana, Idaho (WWAMI) region—including a community, a technological, and a tribal college—and are building upon the success of the Washington Entrepreneurial REACH (WE-REACH) at the University of Washington. Participating institutions and innovators will gain access to funding, training, and resources to guide the research and development of new medical products, ultimately fostering a pro-entrepreneurial culture across the region, creating new small businesses, and bringing products to market that address disease burden and health disparities. 1

PI_NAMEs: BROWN, KAREN ;WOODAHL, ERICA L (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Academia;Academic support;Acceleration;Address;Alaska;Area;Biological Sciences;Biomedical Research;burden of illness;Businesses;Clinical;Collaborations;college;commercialization;Communities;community college;Death Rate;design;Development;Devices;Diagnostic;Economic Development;Ecosystem;Ensure;Entrepreneurship;Equity;Evaluation Research;experience;Fostering;Funding;Geography;Goals;Growth;Health;health disparity;health disparity populations;Health Personnel;Health system;Human;Idaho;Industry;Infrastructure;innovation;Institution;Investments;Leadership;Legal;Life Cycle Stages;Location;Marketing;Medical;Medical Device;medically underserved population;Mentors;metropolitan;Minority;Modeling;Montana;next generation;novel diagnostics;Pathway interactions;Persons;Pharmaceutical Preparations;Positioning Attribute;product development;programs;prototype;Recording of previous events;Research;research and development;Research Personnel;Resource Allocation;Resource-limited setting;Resources;Rural;Rural Community;success;System;technical college;Technology;Therapeutic;Training;Translations;tribal college;tribal community;tribal institution;Tribes;undergraduate student;underserved community;United States;United States National Institutes of Health;Universities;Washington;Woman;Wyoming

PROJECT_TITLE: Rocky Mountain REACH (RMT-REACH)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Interstitial fibrosis a strong predictor of future decline in kidney function and development of kidney failure is not readily available in most patients with kidney disease because: a) A kidney biopsy which is rarely performed is needed to estimate interstitial fibrosis and b) A non-invasive test to estimate interstitial fibrosis is not available. Kidney ultrasonography is a routine non-invasive test in assessment of kidney disease and the current study will utilize artificial intelligence techniques to develop a model to estimate interstitial fibrosis from a kidney ultrasonography image. The proposed research is relevant to NIH mission because developing a non-invasive test to estimate interstitial fibrosis and tubular atrophy will lead to better prediction of future decline in kidney function and monitoring of treatment in all patients with kidney disease.

PI_NAMEs: ATHAVALE, AMBARISH  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Age;aged;Albuminuria;Algorithms;Artificial Intelligence;Atrophic;Biopsy;blind;Body Size;Chronic Kidney Failure;Clinical;clinical biomarkers;clinical practice;clinical predictors;clinically relevant;cohort;Data;deep learning;deep learning model;Development;Disease;Disease Progression;Elderly;Etiology;Evaluation;Fibrosis;Future;Gender;Goals;hazard;Hemorrhage;histopathological examination;Image;improved;Individual;interstitial;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;kidney imaging;Length;Methods;Mission;Modeling;Monitor;nephrogenesis;novel therapeutics;Outcome;Pathologist;Patients;Performance;Persons;Plug-in;Population;Prognosis;prognostic;prognostication;programs;radiologist;Reading;Renal function;Reproducibility;Research;routine imaging;Severities;Severity of illness;Slide;System;Techniques;Testing;Therapeutic immunosuppression;Time;tool;treatment response;Tubular formation;Ultrasonography;ultrasound;United States National Institutes of Health;user-friendly;Validation;virtual;Work

PROJECT_TITLE: Development and Validation of a Deep Learning system to estimate Interstitial Fibrosis from a kidney ultrasonography image

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

ORG_STATE: TX

PHR: CURED OVERALL: Project Narrative The BCM-TSU P20 “Collaborative Union for Cancer Research, Education and Disparities (CURED)” Proposal will establish a formal collaborative alliance between BCM and TSU for cancer research, education, and community outreach. Our multipronged approach will maximize the strengths of each institution and leverage existing collaborative relationships to create a shared infrastructure between BCM and TSU that will provide an optimal environment for cancer research, education, community outreach, and opportunities for career development and pathway enhancement focused on diversifying the biomedical workforce. BCM-TSU P20 CURED will also develop sustainable research capacity and obtain preliminary data through pilot projects that will develop into independent investigator research applications and collaborative applications to the NIH/NCI and/or other Federal/Non-federal funding agencies.

PI_NAMEs: AJEWOLE, VERONICA B. (contact);ROUCE, RAYNE HELEN

PROGRAM_OFFICER_NAME: AGUILA, HECTOR NELSON

PROJECT_TERMS: Address;Advisory Committees;African American;anti-cancer research;Area;Cancer Center;cancer education;cancer health disparity;career;Career Choice;career development;Collaborations;college;Communities;Community Health Education;Community Outreach;Comprehensive Cancer Center;cost;Cost Allocation;Data;Degree program;design;Development;Disparity;Education;Education and Outreach;education research;Educational Curriculum;Effectiveness;Emerging Technologies;empowerment;Ensure;Environment;ethnic diversity;Evaluation;experience;Exposure to;Facilities and Administrative Costs;Faculty;Fostering;Funding;Funding Agency;Goals;graduate student;Health Disparities Research;higher education;Historically Black Colleges and Universities;improved;Infrastructure;innovation;Institution;Joints;Lead;Leadership;Malignant Neoplasms;Medical center;Medicine;member;Mentors;Minority Health Research;National Cancer Institute;outreach;outreach program;Pilot Projects;Prevention;Process;Program Development;programs;Research;research and development;Research Peer Review;Research Personnel;Resources;Schools;Science;Students;summer student;Texas;Training;Training Support;undergraduate student;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: 2/2 Collaborative Union for Cancer Research, Education, and Disparities (CURED)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE – CURED Administrative Core The goal of the Administrative Core in the BCM-TSU P20 Collaborative Union for Cancer Research, Education and Disparities (BCM-TSU P20 CURED) program will be to ensure continuity of the strong and productive ongoing partnership between BCM and TSU enhance cancer research and education capacity at both BCM and TSU while promoting the diversity of the cancer research workforce. The CURED proposes to not only provide integrated administrative support, promote recruitment and increase diversity, but also provide scientific oversight and promote sustainable collaborations in the areas of research, education and community outreach.

PI_NAMEs: AJEWOLE, VERONICA B. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Annual Reports;anti-cancer research;Area;Budgets;cancer care;cancer education;cancer health disparity;Career Choice;Catchment Area;Clinical Research;Collaborations;college;Communication;Communities;Community Outreach;Comprehensive Cancer Center;data management;data sharing;Disparity;Disputes;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;empowerment;Ensure;equity, diversity, and inclusion;Ethics;Evaluation;experience;Faculty;Funding;Goals;Grant;Guidelines;Health Disparities Research;health disparity;Historically Black Colleges and Universities;Human Resources;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;Medical center;Medicine;meetings;member;Minority Groups;National Cancer Institute;outreach;Pharmacology;Pilot Projects;Policies;Productivity;programs;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;Resources;Scientist;Structure;Students;synergism;Texas;Training;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;Veronica;Work

PROJECT_TITLE: BCM/TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED) Administrative Core (AC)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: SANTA CLARA

ORG_NAME: AUTONOMOUS HEALTHCARE, INC.

PHR: Addressing the drug diversion problem is a multi-faceted problem involving many components ranging from provider training to implementation of hardware and software systems to manage access to controlled substances. However, despite recent improvements in controlling and monitoring access to controlled substances, the process of identifying drug diversion and ensuring compliance is complicated and time consuming. Our overall goal is to further develop a technology based on blockchains to track and document transportation and administration of controlled substances in a hospital environment and detect drug diversion.

PI_NAMEs: GHOLAMI, BEHNOOD  (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Address;Adherence;Administrator;Adopted;Adoption;Algorithmic Analysis;Algorithms;Ambulatory Surgical Procedures;Architecture;blockchain;Cellular Phone;Clinic;Clinical;cloud based;Collaborations;Computer software;Computerized Medical Record;Consumption;Coupled;Data;Data Analyses;data dashboard;Data Set;Detection;Development;digital;Documentation;dosage;drug testing;Electronics;Ensure;Environment;Event;Feedback;Goals;Health care facility;Health system;Hospitals;improved;in silico;Information Systems;Investigation;Learning;Location;Machine Learning;Measures;Medication Management;Medication Systems;Modeling;Monitor;Movement;multiple data sources;Paper;Pharmaceutical Preparations;Phase;pilot test;Policies;prevent;Process;programs;Protocols documentation;Provider;Records;Sensitivity and Specificity;simulation;smartphone application;software systems;substance use;System;Technology;Testing;Time;Training;Transportation;Update;Work

PROJECT_TITLE: Using Machine Learning and Blockchain Technology to Reduce Drug Diversion in Hospitals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have recently emerged as a new treatment strategy for hormone receptor (ER/PR) positive (HR+), human epidermal growth factor receptor 2 (HER2)-negative (HR+/Her2-) subtype of breast cancer (BC) patients. Recent studies suggest that their benefit may be restricted only to non-Hispanic European American (EA) BC patients, without significant improvement in African American (AA) or Hispanics patients. Using patient interviews, computational modeling and functional studies, this project will analyze the social determinants and genetic aspects contributing to CDK4/6i therapy resistance in AA BC patients.

PI_NAMEs: HUNTER, RODNEY  (contact)

PROJECT_TERMS: Address;Adherence;Affect;African American;African American Women;American;anti-cancer research;Atlases;Awareness;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Etiology;cancer genomics;CDK4 gene;Cessation of life;Clinical;Code;Computer Models;Data;Databases;Death Rate;Decision Making;design;differential expression;Disparity;Documentation;Drug resistance pathway;Early Diagnosis;Education;Electronic Health Record;Environmental Risk Factor;Epidermal Growth Factor Receptor;Epigenetic Process;Ethnic Origin;European;FAT gene;Financial Hardship;Frequencies;Genes;Genetic;Genetic Predisposition to Disease;Genetic Variation;genomic data;Genomics;Germ Lines;Head and Neck Cancer;Hispanic;Hispanic Populations;hormone receptor-positive;hormone therapy;Human;improved;In Vitro;individual patient;information gathering;inhibitor;inhibitor therapy;Interview;Malignant Breast Neoplasm;Malignant Neoplasms;markov model;medication compliance;Messenger RNA;Metastatic breast cancer;mRNA Expression;Mutation;Not Hispanic or Latino;novel therapeutic intervention;Oral;Outcome;outcome disparities;patient population;Patients;Pattern;Pharmaceutical Preparations;Population;Population Study;Prevalence;Progression-Free Survivals;Quality of life;Race;racial disparity;RB1 gene;Resistance;Resistance development;resistance mechanism;screening;side effect;social determinants;social health determinants;Social support;statistics;Surveys;targeted treatment;Testing;The Cancer Genome Atlas;therapy resistant;Treatment outcome;treatment site;tumor;United States;Variant;verbal;Woman;Women's mortality;women's outcomes

PROJECT_TITLE: Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Despite receiving significant NIH research funding, Texas academic researchers face major challenges as they seek to commercialize their discoveries, including a lack of training and support programs to help them appropriately value and validate their technology. To address this deficit, the Gulf Coast Consortia Research Evaluation and Commercialization Hub (GCC-REACH) will assist academic and medical entrepreneurs to effectively, efficiently, and successfully commercialize their biomedical discoveries. The GCC-REACH is a multi- institutional trans-Texas resource that will be based in Houston's Texas Medical Center and operated by the Gulf Coast Consortia.

PI_NAMEs: DAVIES, PETER J (contact);TOMLINSON, SUZANNE MARIE;WATOWICH, STANLEY J

PROJECT_TERMS: Academic Training;Address;Admission activity;Agreement;Area;Award;Biological Sciences;Biomedical Research;Biomedical Technology;Biotechnology;Businesses;Cancer Center;career networking;catalyst;Clinic;Clinical;Clinical Trials;Collaborations;college;commercialization;Complex;design;Development;drug development;drug discovery;Ecosystem;Education;education resources;Educational Activities;Educational process of instructing;Eligibility Determination;Employment Opportunities;Ensure;Equilibrium;Evaluation Research;experience;Face;Funding;Goals;Growth;gulf coast;Health;Health Professional;Health Sciences;Healthcare;Hospitals;improved;Incubators;Infrastructure;innovation;Institution;Intellectual Property;Investments;Joints;Laboratories;Leadership;Legal;Link;Malignant Neoplasms;Marketing;Medical;Medical center;medical schools;Medicine;member;Mentors;Mentorship;Methodist Church;Mission;novel;Outcome;Participant;Patients;Personal Satisfaction;Pharmacologic Substance;Process;programs;Records;Research;research facility;Research Institute;Research Personnel;Resources;Rice;Services;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Stream;success;Talents;Technology;technology development;Technology Transfer;Texas;Therapeutic;Time;timeline;Training;Training Programs;Translating;Trust;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Gulf Coast Consortia (GCC) Research Evaluation and Commercialization Hub


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Natural Products;Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans Cannabis use is associated with negative outcomes including cannabis use disorder (CanUD), psychosis, and cognitive impairment. We propose a translational research program to 1) understand the genetics of CanUD, and 2) study the influence of genetic risk for CanUD and SCZ on the effects of cannabinoids administered in human laboratory studies and clinical trials.

PI_NAMEs: D'SOUZA, DEEPAK CYRIL (contact);GELERNTER, JOEL

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acute;addiction;Attention;Biology;Cannabidiol;cannabinoid administration;cannabinoid treatment;Cannabinoids;Cannabis;Clinical;Clinical Trials;Cognitive;commercialization;Complex;Data;Data Pooling;Data Set;Development;disorder risk;Double-Blind Method;DSM-V;Etiology;European;experimental study;FAAH inhibitor;Funding;Genetic;Genetic Risk;Genetic study;genome wide association study;genome-wide;Genomics;Heritability;Human;human subject;Impaired cognition;Impairment;improved;Infusion procedures;Investigation;Laboratory Study;Legal;Link;London;Maps;marijuana use;marijuana use disorder;marijuana user;Medical Marijuana;Memory;Mendelian randomization;Meta-Analysis;Methodology;Methods;Multicenter Trials;National Institute of Drug Abuse;Nature;novel;Outcome;Pain;painful neuropathy;Pathogenesis;Pharmacology;Phenotype;Placebo Control;polygenic risk score;Population;population based;predicting response;Productivity;programs;prospective;psychiatric genomics;Psychiatry;Psychoses;Publishing;Randomized;Recreation;Research;response;Rewards;Risk;risk variant;Safety;Sampling;Schizophrenia;Services;Severities;side effect;Statistical Data Interpretation;Tetrahydrocannabinol;trait;translational research program;Translations;Veterans;Vulnerable Populations;whole genome;Work

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PHR: CURED PILOT Project 2 Narrative Recognizing the interconnection between public health and the built environment, this research—about the racial disparities in the association between bladder cancer outcomes and neighborhood socioeconomic characteristics and environmental condition—will contribute to a depth in understanding within the public health community about the ways in which housing is one of the most important social determinants of health outcomes.

PI_NAMEs: SOLITARE, LAURA  (contact)

PROJECT_TERMS: Address;African American;African American population;American;anti-cancer research;Antineoplastic Agents;Behavior;Biological;Biological Factors;Biology;Biomedical Research;built environment;cancer health disparity;Cancer Patient;Cancer Research Project;carcinogenicity;Carcinogens;Categories;Censuses;Characteristics;Clinical;Collaborations;college;Communities;Community Developments;community engagement;Community Health;Comprehensive Cancer Center;Consent;contextual factors;Cross-Sectional Studies;Cystectomy;Data;Data Set;Development;Disadvantaged;Disease Progression;Disparate;Disparity;DNA;DNA Methylation;drug discovery;Drug Kinetics;Economics;Education;education research;Environment;Environmental and Occupational Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;ethnic minority;Ethnic Origin;European;Event;Exhibits;experience;Faculty;Functional disorder;Genes;Geographic Information Systems;Health;health care availability;health data;health disparity populations;Health Services Accessibility;Historically Black Colleges and Universities;Housing;Human;Incidence;Individual;Industry;Inferior;Infrastructure;Institution;Intervention;Interview;Interviewer;Joints;Life Cycle Stages;Link;Lived experience;Location;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Medicine;member;Methylation;methylation pattern;Minority Groups;Modification;Molecular and Cellular Biology;mortality;neighborhood disadvantage;Neighborhoods;Neoplasm Circulating Cells;Neoplasm Metastasis;Occupational;Occupational Exposure;Outcome;Outcome Measure;outreach;Pathway interactions;Patients;Persons;Pilot Projects;Plants;Play;Policies;Policy Research;Printing;Prognostic Marker;programs;Public Health;Race;racial disparity;racial minority;Recording of previous events;recruit;Reporting;Research;Resource Sharing;Risk;Role;Rubber;Running;Smoking History;social culture;Social Environment;social factors;social health determinants;socioeconomics;software systems;Source;Specimen;stressor;Surveys;Testing;Texas;Textiles;timeline;Tissue Sample;tumor;Tumor Bank;tumor progression;U.S. Department of Housing and Urban Development;Universities;Work;Workplace;Xenobiotics

PROJECT_TITLE: Racial and social contextual factors in relation to epigenome and bladder cancer outcome


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Many barriers exist for the efficient delivery of therapeutic genes to cells, animals, and patients for effective treatment of disease. Our work will discover what these barriers are, how they work, and how they can be overcome in order to improve DNA delivery and gene therapy.

PI_NAMEs: DEAN, DAVID A (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affect;Affinity;Animals;Architecture;Binding;Binding Sites;Cell division;Cell membrane;Cell Nucleolus;Cell Nucleus;Cells;Complex;CREB1 gene;cytokine;Cytoplasm;Cytoskeleton;defense response;Disease;DNA;DNA Binding;DNA Binding Domain;DNA cassette;DNA delivery;DNA Polymerase I;DNA Polymerase II;DNA Polymerase III;DNA Sequence;ds-DNA;effective therapy;Gene Delivery;Gene Expression;Gene Order;gene therapy;Gene Transfer;Genes;Genetic Materials;Genetic Transcription;Goals;Host Defense;Immune response;Importins;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;Interferons;Interphase Cell;Laboratories;mechanical force;Mediating;Messenger RNA;Methods;Microtubules;Motor;Movement;NF-kappa B;NFIA gene;Normal Statistical Distribution;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Localization Signal;Pathway interactions;Patients;plasmid DNA;Plasmids;Polymerase;Production;promoter;Proteins;Receptor Signaling;release factor;residence;Ribosomal RNA;RNA Polymerase II;RNA Splicing;sensor;Signal Transduction;Site;small hairpin RNA;Stimulator of Interferon Genes;therapeutic gene;Time;Tissues;trafficking;transcription factor;Transfection;transgene expression;Travel;Viral;Work

PROJECT_TITLE: Intracellular Trafficking of DNA for Gene Therapy


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: CURED C-REP Project Narrative The CURED C-REP will provide an 8-weeks mentored cancer research experience that integrates Baylor College of Medicine (BCM) and Texas Southern University (TSU) infrastructures every summer followed by year- long culturally congruent outreach education activities that will increase the awareness, knowledge, and understanding of research, concepts, processes, and careers in cancer research/cancer health disparities a cohort of 20 underrepresented minority students from TSU. The proposed CURED C-REP will enhance cancer research education capacity at TSU, promote the diversity of the cancer research workforce and improve BCM’s effectiveness in developing and sustaining research programs focused on cancer health disparities.

PI_NAMEs: XIE, HUAN  (contact)

PROJECT_TERMS: Address;Advertisements;anti-cancer research;Awareness;Biomedical Research;Cancer Center;cancer education;cancer health disparity;career;Career Choice;Career Mobility;Clinical;Clinical Research;cohort;Collaborations;college;Communication;Communities;community engagement;Complex;Comprehensive Cancer Center;Core Facility;County;Dedications;design;Development;Disparity;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Effectiveness;Environment;Event;experience;Faculty;Fellowship;Future;Goals;Health Disparities Research;health disparity populations;Health Services;Healthcare;Historically Black Colleges and Universities;Hour;improved;Incidence;Infrastructure;innovation;Institution;interest;Knowledge;Laboratories;Malignant Neoplasms;Mass Media;Medical center;Medicine;member;Mentors;Mentorship;Minority Groups;minority trainee;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;novel;outreach;Pharmacology;Pharmacy facility;Pilot Projects;Postdoctoral Fellow;Printed Media;Process;programs;racial diversity;Records;recruit;Research;Research Infrastructure;Research Personnel;Residencies;Science;skills;social media;Students;summer program;summer research;symposium;Technology;Texas;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student

PROJECT_TITLE: BCM/TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED) Collaborative Cancer Research Education Program (C-REP)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: RELEVANCE TO PUBLIC HEALTH  Millions of Americans suffer from Fibromyalgia syndrome (FMS) and experience severe disability and diminished quality of life, making it a significant public health problem. The goal of this project is to develop and validate a multivariate regression index in rats that will mimic current clinical fibromyalgia indices which will be used to evaluate the suitability of a novel rat model of FMS. This model will be highly desirable for drug screening and pharmacologic testing because it will exhibit improved face, construct and predictive validities compared with existing preclinical FMS models.

PI_NAMEs: TAYLOR, NORMAN  (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: affective disturbance;allodynia;American;analog;Animal Model;animal pain;Animals;Anxiety;Area;associated symptom;Behavioral;biological adaptation to stress;Certification;Characteristics;Chronic;chronic widespread pain;Clinical;Clinical effectiveness;clinical pain;clinical phenotype;clinical predictors;Clinical Trials;Cognitive;cohort;cost estimate;Dahl Hypertensive Rats;Data;debilitating pain;Development;Dexamethasone;Diagnosis;Diagnostic;Diet;diffuse noxious inhibitory control;Dimensions;disability;Disease;drug development;Drug Screening;duloxetine;Endocrine;Evaluation;Exhibits;experience;experimental study;Face;Fatigue;FDA approved;Female;Fibromyalgia;functional disability;Functional disorder;gabapentin;Genetic;Genetic Predisposition to Disease;Goals;Healthcare;Human;human disease;Hyperalgesia;Immune;Impaired cognition;Impairment;improved;indexing;Individual;Indomethacin;innovation;Intervention;male;Measurement;Measures;mechanical allodynia;mechanical pressure;Mechanics;Mental Depression;Methods;midalcipran;Modeling;Moods;Muscle;neural;neuroinflammation;normotensive;novel;novel therapeutics;Outcome;Pain;Pain management;Pain Measurement;pain model;Pathogenesis;Persistent pain;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;pre-clinical;pregabalin;pressure;Productivity;Public Health;Quality of life;Rat Strains;Rattus;Rattus norvegicus;Research;Research Personnel;Reserpine;response;Risk;Rodent;Rodent Model;salt sensitive hypertension;Scandinavian;secondary endpoint;Signs and Symptoms;Sleep;Sleep disturbances;Sodium Chloride;Sprague-Dawley Rats;Stimulus;Symptoms;Syndrome;System;systemic inflammatory response;Testing;Therapeutic Effect;therapeutic effectiveness;therapeutic evaluation;trait;Translations;Twin Multiple Birth;Validation

PROJECT_TITLE: Development and Validation of a Novel Rat Model of Fibromyalgia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Impacts of hurricanes and social buffering on biological aging in a free-ranging animal model Age is the strongest predictor of risk for a multitude of diseases, yet the extent to which natural disasters impact aging remains unclear. This project investigates how and in what ways major natural disasters, in the form of hurricane impacts, have modified the pace of aging in a nonhuman primate model, the rhesus macaque. Our results will reveal how and to what extent natural disasters impact the onset of age-related declines, which will inform the targeted development of behavioral and physiological interventions that could reduce the burden of aging-related disease in our aging population.

PI_NAMEs: BRENT, LAUREN JOHANNA NICOLE;HIGHAM, JAMES P (contact);SNYDER-MACKLER, NOAH

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Adverse event;Affect;Age;age acceleration;age effect;Age of Onset;age related biomarkers;age related decline;age-related disease;Aging;aging population;aging process;aging related disease;Animal Model;Animal Testing;Animals;Autopsy;Behavior;Behavioral;biological age;Biological Aging;Biology;Blood;Body fat;Body System;Brain;Buffers;Cardiovascular Diseases;Cells;Cessation of life;Chronology;Data;Development;Disasters;Disease;Disproportionately impacts women;Economics;Emigrations;Ethics;Exhibits;experience;Experimental Models;Exposure to;Face;Female;Floods;Florida;frailty;Frequencies;Gene Expression Regulation;Health;healthspan;Heart;Human;Hurricane;Immune;immune activation;Incidence;Individual;Inflammation;insight;Intervention;Investigation;Island;joint mobilization;life span;Link;Longitudinal Studies;Macaca;Macaca mulatta;male;man;Measures;member;Mitochondria;Modeling;Molecular;molecular marker;Monkeys;Movement;Muscle;muscle form;Natural Disasters;Natural experiment;nonhuman primate;Outcome;Persons;Physiological;Population;Process;Puerto Rico;quantification of aging;rate of aging;Resources;response;Risk;Risk Factors;Risk Marker;Sampling;sex;Skin;social;social integration;social relationships;Social status;Social support;stressor;Stroke;Structure;Survivors;Telomere Shortening;Testing;Texas;Tissue Sample;Tissues;trait;Variant;welfare

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: SYRACUSE

ORG_DEPT: PHYSICS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Protein kinases represent a significant group of strategic drug targets because there is overwhelming evidence for their critical implications in numerous cancers. The immediate outcomes of these proposed studies will impact healthcare by providing a generalizable and high-resolution technology for analyzing diverse protein kinases.

PI_NAMEs: MOVILEANU, LIVIU  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Affinity;Algorithmic Analysis;antibody mimetics;Applications Grants;Basic Science;Binding;Biological Assay;Biosensor;Biotechnology;casein kinase II;Caseins;Catalytic Domain;Cell Physiology;cofactor;Competitive Binding;Complex;complex data;Cyclic AMP-Dependent Protein Kinases;Dependence;design;Detection;Development;Devices;Diagnostic;drug discovery;Drug Targeting;Electrophysiology (science);Elements;Engineering;Enzymatic Biochemistry;Enzymes;Epidermal Growth Factor Receptor;Event;Face;FDA approved;Generations;Grain;Growth Factor;Healthcare;Hematologic Neoplasms;Human;Hyperactivity;inhibitor;innovation;inorganic phosphate;Integral Membrane Protein;Kinetics;Label;Lead;leukemia;Ligands;Malignant Neoplasms;Measurement;Measures;Mediating;Medical;member;Methods;Microelectrodes;Modality;Modeling;molecular diagnostics;molecular dynamics;Moloney Leukemia Virus;nanopore;nanosensors;Nanostructures;new technology;Noise;Outcome;overexpression;Peptides;Performance;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;polypeptide;Post-Translational Protein Processing;preservation;prognostic;Protein Dynamics;Protein Engineering;Protein Isoforms;Protein Kinase;Protein Kinase Interaction;protein protein interaction;Protein-Serine-Threonine Kinases;Proteins;Receptor Protein-Tyrosine Kinases;Reporter;Reporting;Resolution;response;Sampling;screening;sensor;Serum;Signal Pathway;Signal Transduction;single molecule;small molecule;small molecule inhibitor;Solid Neoplasm;Specificity;Substrate Interaction;synthetic biology;Tail;Technology;Time;tool

PROJECT_TITLE: Generalizable Nanosensors for Probing Highly Specific Interactions of Protein Kinases

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTHER BASIC SCIENCES

PHR: The proposed work is relevant to public health, given its focus on unraveling molecular mechanisms of Alzheimer’s disease, which can be extended to other neurodegenerative diseases. The proposed research will help to explain how the disease- prone protein aggregates appear and develop, which in future studies will be used to develop approaches controlling the aggregation process. Thus, the proposed research is relevant to the NIH’s mission pertaining to developing fundamental knowledge that will improve preventive and therapeutic treatments for diseases.

PI_NAMEs: LYUBCHENKO, YURI L (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: abeta accumulation;abeta oligomer;Aging;Alzheimer's Disease;Alzheimer's disease therapy;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid formation;Amyloid Proteins;Brain;Calcium;Catalysis;catalyst;Cells;Cellular Membrane;Cholesterol;Computer Models;Data;Development;Diagnostic;Disease;Dissociation;drug discovery;Event;Experimental Models;experimental study;Fatty Acids;Foundations;Future;Ganglioside GM1;Goals;Homeostasis;improved;In Vitro;in vivo;insight;Knowledge;Lipids;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;membrane model;Microscopic;Microtubules;Mission;model development;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;monomer;Mutation;nano;nanoassembly;nanomolar;nanoscale;nanosized;Nerve Degeneration;Neurodegenerative Disorders;neurotoxic;novel;novel strategies;Parkinson Disease;Pathway interactions;Peptide Initiation Factors;Phospholipids;Physiological;prevent;Prevention;Preventive;preventive intervention;Preventive measure;Preventive therapy;Process;programs;Property;protein aggregation;Proteins;Public Health;Research;Role;self assembly;Sphingomyelins;Surface;Synapses;tau-1;Testing;theories;Therapeutic;Therapeutic Intervention;Translating;translational study;Tube;United States National Institutes of Health;Work

PROJECT_TITLE: Nanoscale assembly of amyloid oligomers at physiologically relevant conditions


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

PHR: Narrative The number of drug overdoses in New York continues to rise, with 4,946 deaths involving opioids in 2021. In response, the New York State Office of Addiction Services and Supports (OASAS) is promoting new approaches that embrace person-centered care, evidence-based practices, equitable treatment, and harm reduction principles. OASAS and New York University will build a quality measurement and management (QM2) research center that provides performance feedback to activate leadership and staff of clinics to improve practice as well as publicizes quality measures to ensure public accountability.

PI_NAMEs: HECK, ANDREW ;LINCOURT, PATRICIA ;NEIGHBORS, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accountability;Accounting;addiction;Address;Adoption;Adverse event;Ambulatory Care Facilities;Automobile Driving;Black Populations;care systems;Caring;Cessation of life;Characteristics;Client;Clinic;Clinical;Collaborations;Communities;Consult;Contracts;Data;Data Analyses;data literacy;Development;Drug Metabolic Detoxication;Drug user;Effectiveness;effectiveness testing;Electronic Health Record;Elements;Ensure;Equity;Event;evidence base;Evidence based practice;Family;Feedback;Funding;Goals;Government;Harm Reduction;Health;health inequalities;Healthcare;Hospitalization;improved;Individual;Insurance Carriers;Intervention;Interview;Investments;Latinx population;Leadership;Measurement;Measures;Mediation;Medicaid;medication for opioid use disorder;Methods;Monitor;mortality;New York;novel strategies;Opioid;opioid epidemic;opioid use disorder;Outcome;Overdose;overdose death;Patient-Focused Outcomes;Patients;Perception;Performance;person centered;Pharmaceutical Preparations;Policies;Process;Professional counselor;Property;Psychometrics;Qualitative Methods;Quality of Care;Questionnaires;Recording of previous events;Registries;Reporting;Research;Resistance;response;Risk Adjustment;Science;Services;social vulnerability;Statistical Methods;Substance Use Disorder;substance use treatment;Surveys;synthetic opioid;System;Technology;Testing;tool;treatment center;treatment services;Universities;user centered design;Validation;Variant;Vital Statistics;Work

PROJECT_TITLE: Person-centered quality measurement and management in a system for addictions treatment in New York State


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: The proposed research is relevant to public health because it will characterize a novel molecular mechanism by which cells control the expression of TAR DNA-binding protein-43 (TDP-43) through RNA modification of its transcript. Because TDP-43 pathology is present in a wide array of neurodegenerative diseases, these findings will have an important impact by advancing our mechanistic understanding of TDP-43 requirement for neuronal survival and by providing new targets for innovative therapies for age-related TDP-43 proteinopathies.

PI_NAMEs: LOTTI, FRANCESCO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;age related;age related neurodegeneration;Alzheimer's Disease;Attention;Behavioral;Binding;Brain Stem;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cost;Cytoplasm;Data;demented;Development;Disease;embryonic stem cell;Ensure;epitranscriptome;epitranscriptomics;Event;Failure;Foundations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Gene Mutation;Genes;Genetic;Homeostasis;human disease;Impairment;Informal Social Control;innovation;Innovative Therapy;insight;Light;Link;Liquid substance;Mediating;Membrane;Messenger RNA;Modification;Molecular;Morphology;motor neuron degeneration;motor neuron function;Motor Neurons;mouse model;Mus;Muscle;Muscle Fibers;Mutation;Nerve Degeneration;nerve supply;Nervous System;Nervous System Disorder;Neurites;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;neurotoxicity;novel;Organelles;Output;Paralysed;Pathogenesis;Pathology;Pattern;Persons;pharmacologic;Phase;Phenotype;Physiological;Post-Transcriptional Regulation;posttranscriptional;Predisposition;Process;protein expression;protein TDP-43;Proteins;proteostasis;Public Health;Regulation;Research;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;single nucleus RNA-sequencing;Site;spatiotemporal;Spinal;Spinal Cord;stem;Stress;TDP-43 aggregation;Techniques;Testing;Therapeutic;therapeutically effective;Transcript;Up-Regulation;Work

PROJECT_TITLE: METTL3-mediated regulation of motor neuron function

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases in humans. Although the disease has been studied for decades, we still do not have a clear understanding of the mechanisms regulating the development of cutaneous AD. In this proposal, we will characterize a novel biological mechanism that involves fibroblast dysregulation in the formation of AD-like lesions in mice, examine similar events in human AD specimens and test potential therapies.

PI_NAMEs: GRAVES, DANA T (contact);JACOBSON, DANIEL A;KO, KANG I;SEYKORA, JOHN T.

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Ablation;Adult;Affect;Agreement;Antibodies;Antigens;ATAC-seq;Atopic Dermatitis;Automobile Driving;Biological;Biological Markers;CCL11 gene;Cells;chemokine;Childhood;cost;Cutaneous;Data;Databases;Dermal;Dermis;Development;Disease;Disease Progression;eosinophil;Eosinophilia;Epidermis;Epithelium;Event;experimental study;Fibroblasts;Genetic;Goals;Histologic;Homeostasis;Human;Immune;Immune response;Impairment;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Lesion;Literature;Mediating;Modeling;Molecular;Molecular Target;mouse model;Mus;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Perinatal;Persons;Phenotype;Phosphotransferases;pre-clinical;preclinical study;Prevalence;prevent;Primary Lesion;Production;Pruritus;Public Health;Publications;Publishing;Reaction;Reporting;Research;response;RNA Interference;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;skin lesion;skin organogenesis;small molecule therapeutics;Specimen;subcutaneous;Subcutaneous Tissue;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Translating;translational study;Up-Regulation

PROJECT_TITLE: Fibroblast dysregulation promotes dermal eosinophilic/Th2 inflammation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Complementary and Integrative Health;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of the University of Maryland BaltImore Life Science Discovery (UM-BILD) Accelerator is to create a new NIH Research Evaluation and Commercialization Hub (REACH) program that serves as a development engine to build the life science economy in West Baltimore and Greater Baltimore and to train one of the most diverse biomedical and entrepreneurial workforces in the US. Formed from a partnership by University of Maryland, Baltimore, the University of Maryland School of Medicine, University of Maryland, Baltimore County, Morgan State University, University of Maryland College Park, and the Maryland Innovation Initiative, UM-BILD will embrace existing partner programmatic efforts to increase biomedical workforce diversity such as the University of Maryland FIRST program. Enabled by a greater than $5 million non-federal match, the UM-BILD hub will: 1) provide pilot funds for commercialization-potential technologies to advance to the next stage; 2) utilize internal core services/equipment as a dedicated-life science incubator; 3) offer dedicated business training programs to diverse investigators and founders; and 4) mentor and network innovators for fundraising to further advance successful technology projects (SBIR/STTR awards, venture capital).

PI_NAMEs: ROSE, JASON J (contact);STEINER, KARL V.;WEBER, DAVID JOSEPH

PROJECT_TERMS: Address;Admission activity;African American;Appointment;Area;Award;Baltimore;Biological Products;Biological Sciences;Biomedical Research;Biotechnology;Black race;Businesses;Cancer Biology;Capital;cohort;college;commercialization;County;curriculum development;Dedications;Development;Diagnostic;Doctor of Philosophy;Economics;Employee;Environment;Equipment;Equity;Evaluation Research;fabrication;Faculty;Female;Fostering;Funding;Goals;Grant;Growth;health information technology;Hispanic;Historically Black Colleges and Universities;Immunology;Incubators;Industry;Infrastructure;innovation;Institution;Investments;Laboratories;laboratory development;Latino;Letters;Maryland;Medical Device;medical schools;Mentors;Microbiology;Minority-Serving Institution;Neurosciences;Performance;Pharmaceutical Preparations;Population;Positioning Attribute;Privatization;Product Approvals;Productivity;programs;recruit;Research;Research Personnel;Resource Development;Resources;satisfaction;Scholars Program;Scientist;Services;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;STEM field;success;System;Technology;tenure track;Training;Training Programs;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Vaccines


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Single-particle cryogenic electron microscopy (cryo-EM) is electron microscopy (EM) of biological molecules embedded in vitreous ice specimens. Time-resolved cryo-EM examines specimens that reflect biomolecular reactions occurring for a series of controlled time durations. We will develop a technology for preparing cryo-EM specimens with submillisecond reaction times to enable time-resolved cryo-EM studies of short-lived intermediate states of biomolecular systems.

PI_NAMEs: LIN, QIAO  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Microfluidic Preparation of Specimens to Enable Submillisecond Time-Resolved Cryo-EM

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative/Public Health Relevance Statement: This research is highly relevant to public health because infertility is a significant problem in a growing population of male childhood cancer survivors. Adapting a web-based sperm banking decision tool to increase usability and acceptability and identifying tailored implementation strategies to ensure feasibility and equity, will improve reproductive outcomes and enhance quality of life. This is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will extend human life and help to reduce the burdens of illness and disability, and specifically NCI’s mission to reduce the burden of cancer morbidity and mortality.

PI_NAMEs: NAHATA, LEENA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: 21 year old;Address;Adolescence;Adolescent;Adoption;Attitude;Behavior Therapy;burden of illness;Cancer Burden;Cancer Center;cancer therapy;Caregivers;Caring;childhood cancer survivor;Chronic Disease;Clinical;Clinical Pathways;Communication;Consult;Control Groups;Counseling;Dedications;design;disability;effectiveness/implementation trial;Enrollment;Ensure;Equity;Evaluation;Family;family building;Feedback;Fertility;fertility preservation;Focus Groups;Funding;Future;future implementation;Goals;group intervention;Guidelines;Hospitals;Human;Impairment;implementation context;implementation strategy;improved;Infertility;Infrastructure;innovation;Inpatients;Institution;Internet;Knowledge;Late Effects;Life;male;Male Adolescents;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Mission;Modification;Morbidity - disease rate;mortality;multidisciplinary;Newly Diagnosed;novel;oncofertility;Online Systems;Organizational Change;Outcome;Outpatients;Parents;Pathway interactions;Patients;Pilot Projects;Population;premalignant;programs;prospective;Provider;psychosocial outcome;Public Health;public health relevance;Quality of Care;Quality of life;Recommendation;Reporting;reproductive outcome;Research;Resource-limited setting;Resources;satisfaction;Services;shared decision making;Site;Son;Sperm Banks;Survival Rate;Survivors;System;Team Process;Testing;Thinking;Time;tool;treatment effect;Underserved Population;United States National Institutes of Health;usability;web platform;web-based tool;Work

PROJECT_TITLE: Adaptation and implementation of a web-based Family centered Adolescent Sperm banking decision Tool for adolescent males with cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: More than 40,000 new rectal cancers occur annually in the US and current treatment strategies (chemotherapy, radiation and surgery) provide a 5-year disease survival of only 65%. Therefore, there is an unmet need for new treatment approaches that improve LARC clinical outcomes and reduce morbidity. We propose to examine adding a new therapy (inhibition of the enzyme IDO1) to rectal cancer therapy that may improve overall cure rates and reduce treatment related toxicity.

PI_NAMEs: CIORBA, MATTHEW AARON (contact);PARK, HAESEONG

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Address;Adjuvant;Age;Anus;Apoptosis;arm;beta catenin;biobank;Biological Markers;biomarker identification;Blood;Cancer Center;Cancer Model;Cancer Patient;cancer therapy;Cervix Uteri;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical diagnosis;Clinical Research;Clinical Trials;cohort;Cohort Studies;Colorectal Cancer;Data;Diagnosis;Disease;DNA Damage;Dose;efficacy evaluation;Enzyme Inhibition;Excision;experience;Experimental Models;Failure;Feces;Gender;genotoxicity;Goals;Growth;Height;Immune;Immunity;Immunooncology;Immunosuppression;Immunotherapy;improved;In complete remission;Incidence;Infrastructure;inhibitor;Institution;Intestines;Kynurenine;Lead;Local Therapy;Malignant Neoplasms;Mediating;Mediator;Mismatch Repair;Morbidity - disease rate;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Oncology;Operative Surgical Procedures;Organoids;Outcome;overexpression;Pathologic;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Pharmacodynamics;Phase;phase 1 study;Phase II Clinical Trials;phase II trial;Phase III Clinical Trials;phase III trial;PI3K/AKT;Positioning Attribute;Pre-Clinical Model;precision medicine;predicting response;programmed cell death protein 1;Radiation;radiation delivery;Radiation Protection;Radiation therapy;Randomized;Rectal Cancer;Rectum;Regimen;repair function;Resistance;response;Safety;Sampling;Site;Small Intestines;Solid Neoplasm;standard of care;Statistical Models;synergism;Therapeutic;therapy resistant;Toxic effect;Treatment Efficacy;treatment response;treatment strategy;Treatment-related toxicity;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;tumor;Tumor Immunity;Tumor Suppressor Proteins;Tumor Tissue;Universities;Washington;Work

PROJECT_TITLE: Targeting Tryptophan Metabolism in Rectal Cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Residential histories provide a historical record of the social and physical environment that can have a lasting impact on health; however, few cancer research studies have incorporated life-course residential histories for underrepresented populations. To remedy this, we will develop methods to reconstruct life-course residential histories for a racially diverse and low socioeconomic population and link to area-level environmental exposures to identify cancer disparities.

PI_NAMEs: ALDRICH, MELINDA  (contact);RAO, J SUNIL;SHRUBSOLE, MARTHA J.

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;Adult;African American;Age;Algorithms;anti-cancer research;Area;Biological;Biometry;Black race;Breast;Cancer Cluster;cancer diagnosis;cancer epidemiology;cancer health disparity;cancer risk;cancer subtypes;Chronic Disease;clinical care;cohort;Cohort Studies;Collaborations;Colorectal;Communities;conflict resolution;Data;data registry;deprivation;design;Dimensions;Disadvantaged;Disparity;Enrollment;Environment;Environmental Exposure;Environmental Pollutants;Epidemiology;Etiology;experience;Exposure disparity;Exposure to;follow-up;Fostering;Goals;Health;health disparity;high risk;High-Risk Cancer;Home;improved;improved mobility;Income;Individual;Individual Adjustment;innovation;interdisciplinary approach;Knowledge;Length;Life Cycle Stages;Link;Location;Low income;Lung;Malignant Neoplasms;marginalized community;marginalized population;Measurement;Measures;medically underserved;Methods;Modeling;Movement;multidisciplinary;Neighborhood Health Center;Neighborhoods;neoplasm registry;novel;Outcome;Ownership;Participant;Pathway interactions;Patient Recruitments;Patient Self-Report;Pattern;Physical environment;poor communities;Population;Population Group;Population Heterogeneity;Poverty;Poverty Areas;Predictive Factor;prospective;Prospective cohort;Prostate;Questionnaires;Race;racial difference;racial disparity;racial diversity;Recording of previous events;recruit;Research;research study;residence;Residential Mobility;Resources;Risk;Risk Factors;Rural;Sampling;sex;social;social adversity;Social Environment;social health determinants;Socioeconomic Status;socioeconomics;Space-Time Clustering;spatiotemporal;structural determinants;Subgroup;Surveys;Telephone;Testing;Time;Translations;Underrepresented Populations;Underserved Population;Vendor

PROJECT_TITLE: Incorporating residential histories into assessment of cancer risk in a predominantly low-income and racially diverse population

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE The Mid-South REACH program will accelerate real-world impact of biomedical innovations through entrepreneurial education, mentorship, and financial support for aspiring entrepreneurs. The significance of this endeavor stems from the potential to turn academic discoveries into real-world products that can help patients and doctors, and to catalyze a medical innovation economy in states that have a robust, yet relatively untapped, pipeline of innovation but limited resources to translate this innovation into knowledge-based biomedical technology industry. Leveraging substantial state and institutional commitments, the Mid-South REACH Hub will exponentially expand its impact and ensure a self-sustaining innovation network.

PI_NAMEs: BELL, CHARLESON SHERARD;CAMPBELL, ALMESHA L.;SHARON, JESSICA ;SORRELL, PAULA ;WEBSTER, ROBERT JAMES (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TITLE: Mid-South REACH Hub


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Real-time fMRI neurofeedback allows participants to volitionally modulate their own brain activity. Here we will test whether neurofeedback can be enhanced by using the signal derived from the brains of others (i.e., brain- to-brain neural transmission) in people with heroin addiction. If a stronger neural alignment during watching of a drug-related movie between people in early as compared to later recovery is associated with decreased cue- induced craving, results could pave the way towards the development of a new intervention to scaffold recovery in heroin addiction.

PI_NAMEs: GOLDSTEIN, RITA Z (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;addiction;alcohol use disorder;Alcohols;Attention;behavioral study;Brain;brain based;brain behavior;Brain region;Cannabis;Characteristics;Chronic;Complex;Coupling;COVID-19 pandemic;craving;cue reactivity;Cues;Data;Development;Disease;Drug Addiction;drug craving;drug of abuse;Drug usage;Early treatment;Environment;executive function;experience;Feedback;Functional Magnetic Resonance Imaging;Goals;Habits;Heroin;Heroin Dependence;heroin use;Human;imaging study;improved;improved outcome;Individual;innovation;Inpatients;interest;Intervention;Knowledge;Learning;Longitudinal Studies;Measures;medication-assisted treatment;Memory;Morbidity - disease rate;mortality;movie;neural;neural circuit;neural patterning;Neurobiology;Neurocognitive;neurofeedback;Neurons;Neurosciences;non-drug;novel;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Overdose;overdose death;Participant;Pattern;Permeability;Persons;Pharmaceutical Preparations;Process;Protocols documentation;Public Health;Recovery;recruit;reinforcer;Relapse;response;Rewards;Sampling;scaffold;Self Direction;Signal Induction;Signal Transduction;Smoker;Stimulant;Stimulus;Substance Use Disorder;successful intervention;Synaptic Transmission;Testing;Time;Training;Work

PROJECT_TITLE: Brain-to-brain neurofeedback during naturalistic dynamic stimuli to reduce craving in heroin addiction

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Group 1 CD1 molecules present both microbial and self-lipid antigens to T cells. However, little is known about how these lipid-specific T cells are regulated and whether they can mount an effective memory T cell response. This study proposes to investigate how hyperlipidemia impacts lipid antigen-specific T cells and to identify molecular signatures associated with memory group 1 CD1-restricted T cells in vaccination and Mycobacterium tuberculosis infection settings. We anticipate that these studies will illuminate new strategies for targeting these T cells in autoimmune disease and vaccine development.

PI_NAMEs: WANG, CHYUNG-RU  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Activities of Daily Living;Acute;Affect;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Apolipoprotein E;Atherosclerosis;Attenuated;Autoimmune Diseases;autoreactive T cell;autoreactivity;Bone Marrow;CD1 Antigens;Cell Compartmentation;Cells;Cellular Metabolic Process;Characteristics;Chimera organism;Chronic;Chronic Phase;Clone Cells;Communicable Diseases;comorbidity;Data;Development;Diet;Disease;Exhibits;Family;feeding;Gene Expression Profile;General Population;Generations;Genetic Transcription;Germ Lines;glucose mycolate;Growth;Health;Helper-Inducer T-Lymphocyte;High Fat Diet;HIV;Human;Hyperlipidemia;Immune response;Immunity;In Vitro;in vivo;Individual;Infection;Inflammation;insight;Kinetics;Lipids;Maintenance;Mediating;member;Memory;microbial;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Mycobacterium tuberculosis;Mycolic Acid;nanoparticle;novel;Pathogenicity;Pathway interactions;Peptides;Phenotype;Phospholipids;Play;Population;Property;Psoriasis;Pulmonary Inflammation;Regulation;response;Role;Signal Transduction;Skin;Specificity;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Thymus Gland;transcriptome;Transgenic Mice;Transgenic Model;Tuberculosis;tuberculosis immunity;Vaccinated;Vaccination;vaccine development;Work

PROJECT_TITLE: The regulation and functions of Group 1 CD1-restricted T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Comparative Effectiveness Research;Cost Effectiveness Research;Osteoporosis

ORG_CITY: Albany

ORG_NAME: BERKELEY MADONNA, INC.

PHR: Project Narrative Osteoporosis affects 10 million older Americans, and is associated with significant morbidity, mortality, and costs. Although there are many effective osteoporosis treatment options, no single therapy is recommended for indefinite use and thus long-term management of osteoporosis involves transitions between agents. Optimal approaches to long-term osteoporosis treatment, including how best to manage sequential and possibly combination use of different types of medications over a patient’s lifetime, are unknown and a major knowledge gap in the field. With the work described in this proposal, we aim to provide evidence to guide treatment decisions over the lifetime for patients with osteoporosis. To do so, we propose to first perform meta-analyses of clinical studies on the efficacy of sequential and combination osteoporosis treatment strategies; and then carry out comprehensive cost-effectiveness analyses to compare the effectiveness and cost-effectiveness of a variety of long-term treatment strategies for patients with osteoporosis with different clinical characteristics.

PI_NAMEs: NAYAK, SMITA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adherence;Adverse event;Affect;Age;Aging;Alendronate;American;Anabolic Agents;Area;arm;beneficiary;bisphosphonate;bone;Bone Density;Bone Diseases;bone loss;bone strength;Calcium;Caring;Categories;Cerebrovascular Disorders;Characteristics;Chronic;Chronic Disease;Clinical;clinical care;clinical efficacy;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;compare effectiveness;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Death Rate;efficacy evaluation;evidence base;Exercise Therapy;experience;Face;falls;Forteo;Fracture;fracture risk;fragility fracture;Future;Hip Fractures;Holidays;human old age (65+);Ibandronate;improved;Individual;innovation;interest;Investigation;Knowledge;Medical;Medicare;men;Meta-Analysis;Modeling;Morbidity - disease rate;mortality;novel;observational cohort study;older adult;Osteoporosis;osteoporosis with pathological fracture;Outcome;Outcome Measure;Patients;Pattern;personalized management;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Physicians;Pneumonia;Population;Postmenopause;prevent;Professional Organizations;Publication Bias;Raloxifene;Recommendation;Recording of previous events;Regimen;relative cost;relative effectiveness;Reporting;Research;Review Literature;Risedronate;Risk;Risk Reduction;Sequential Treatment;skeletal disorder;Spinal Fractures;Subgroup;systematic review;Testing;Therapeutic;Therapeutic Agents;Time;treatment as usual;Treatment Protocols;treatment strategy;United States;United States National Institutes of Health;Vitamin D;Woman;Work;Zoledronic Acid

PROJECT_TITLE: Long-Term Approaches to Treating Osteoporosis

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: CURED OVERALL: Project Narrative The BCM-TSU P20 “Collaborative Union for Cancer Research, Education and Disparities (CURED)” Proposal will establish a formal collaborative alliance between BCM and TSU for cancer research, education, and community outreach. Our multipronged approach will maximize the strengths of each institution and leverage existing collaborative relationships to create a shared infrastructure between BCM and TSU that will provide an optimal environment for cancer research, education, community outreach, and opportunities for career development and pathway enhancement focused on diversifying the biomedical workforce. BCM-TSU P20 CURED will also develop sustainable research capacity and obtain preliminary data through pilot projects that will develop into independent investigator research applications and collaborative applications to the NIH/NCI and/or other Federal/Non-federal funding agencies.

PI_NAMEs: AJEWOLE, VERONICA B.;ROUCE, RAYNE HELEN (contact)

PROGRAM_OFFICER_NAME: AGUILA, HECTOR NELSON

PROJECT_TERMS: Address;Advisory Committees;African American;anti-cancer research;Area;Cancer Center;cancer education;cancer health disparity;career;Career Choice;career development;Collaborations;college;Communities;Community Health Education;Community Outreach;Comprehensive Cancer Center;cost;Cost Allocation;Data;Degree program;design;Development;Disparity;Education;Education and Outreach;education research;Educational Curriculum;Effectiveness;Emerging Technologies;empowerment;Ensure;Environment;ethnic diversity;Evaluation;experience;Exposure to;Facilities and Administrative Costs;Faculty;Fostering;Funding;Funding Agency;Goals;graduate student;Health Disparities Research;higher education;Historically Black Colleges and Universities;improved;Infrastructure;innovation;Institution;Joints;Lead;Leadership;Malignant Neoplasms;Medical center;Medicine;member;Mentors;Minority Health Research;National Cancer Institute;outreach;outreach program;Pilot Projects;Prevention;Process;Program Development;programs;Research;research and development;Research Peer Review;Research Personnel;Resources;Schools;Science;Students;summer student;Texas;Training;Training Support;undergraduate student;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: 1/2 Collaborative Union for Cancer Research, Education and Disparities (CURED)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ROUCE, RAYNE HELEN (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Annual Reports;anti-cancer research;Area;Budgets;cancer care;cancer education;cancer health disparity;Career Choice;Catchment Area;Clinical Research;Collaborations;college;Communication;Communities;Community Outreach;Comprehensive Cancer Center;data management;data sharing;Disparity;Disputes;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;empowerment;Ensure;equity, diversity, and inclusion;Ethics;Evaluation;experience;Faculty;Funding;Goals;Grant;Guidelines;Health Disparities Research;health disparity;Historically Black Colleges and Universities;Human Resources;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;Medical center;Medicine;meetings;member;Minority Groups;National Cancer Institute;outreach;Pharmacology;Pilot Projects;Policies;Productivity;programs;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;Resources;Scientist;Structure;Students;synergism;Texas;Training;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;Veronica;Work

PROJECT_TITLE: BCM-TSU CURED Administration Core (AC)


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Biotechnology;Eye Disease and Disorders of Vision;Substance Misuse

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE To better translate biomedical discoveries from Chicago based Universities, we propose the Chicago Biomedical Consortium Hub for Innovative Technology and Entrepreneurship in the Sciences (CBC – HITES), a service center that provides academic investigators who have ideas for new biopharmaceutical inventions with the research, analysis, planning, and execution needed to turn scientific ideas into commercial products. To ensure that CBC – HITES inclusively grows the Chicago economy, the hub will capture ideas from nine diverse Chicago institutions and (1) include all of the necessary expertise – clinical, technical, regulatory – into the analysis process; (2) integrate end buyers – the Venture Capitalists and industry scouts who fund early biotech ideas – into the funding process; (3) include the operations and execution personnel needed to generate results – project managers – into the post-funding execution and (4) serve as a training ground for Entrepreneurial Fellows who experientially learn by delivering analyses, plans, and execution to the academic innovator and then work in Chicago’s life sciences ecosystem.

PI_NAMEs: NADIG, SATISH N (contact)

PROJECT_TERMS: Active Learning;Address;Area;Award;Biological Products;Biological Sciences;Biotechnology;Businesses;Capital;Cell Therapy;Chicago;Cities;Clinical;Clinical and Translational Science Awards;clinical implementation;clinical translation;Clinical Trials;cohort;commercialization;Community Physician;Development;Discipline;Doctor of Philosophy;Ecosystem;Educational Curriculum;Engineering;Ensure;Entrepreneurship;Equity;Evaluation;experience;experimental study;Familiarity;Feedback;Funding;Funding Agency;gene therapy;health care service organization;Human Resources;Illinois;implementation science;Industry;Infrastructure;innovation;innovative technologies;Institution;interest;invention;Investments;Joints;Knowledge;Leadership;Link;manufacture;Marketing;Medicine;Methods;metropolitan;Modality;Nanotechnology;Nature;novel diagnostics;novel therapeutics;Occupations;operation;Pharmaceutical Preparations;Philanthropic Fund;Physicians;Process;programs;Protein Engineering;recruit;Request for Applications;Research;research clinical testing;Research Contracts;Research Personnel;Resources;Science;science teacher;Scientist;Service delivery model;Services;small molecule;Societies;Spottings;Supervision;Surgeon;synthetic biology;Talents;Technology;Therapeutic;Time;Training;Translating;Translations;Triage;Universities;Validation;Work

PROJECT_TITLE: A Chicago Biomedical Consortium Hub of Innovative Technologies for Entrepreneurship and Science (CBC - HITES)


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have recently emerged as a new treatment strategy for hormone receptor (ER/PR) positive (HR+), human epidermal growth factor receptor 2 (HER2)-negative (HR+/Her2-) subtype of breast cancer (BC) patients. Recent studies suggest that their benefit may be restricted only to non-Hispanic European American (EA) BC patients, without significant improvement in African American (AA) or Hispanics patients. Using patient interviews, computational modeling and functional studies, this project will analyze the social determinants and genetic aspects contributing to CDK4/6i therapy resistance in AA BC patients.

PI_NAMEs: KAIPPARETTU, BENNY ABRAHAM (contact)

PROJECT_TERMS: Address;Adherence;Affect;African American;African American Women;American;anti-cancer research;Atlases;Awareness;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Etiology;cancer genomics;CDK4 gene;Cessation of life;Clinical;Code;Computer Models;Data;Databases;Death Rate;Decision Making;design;differential expression;Disparity;Documentation;Drug resistance pathway;Early Diagnosis;Education;Electronic Health Record;Environmental Risk Factor;Epidermal Growth Factor Receptor;Epigenetic Process;Ethnic Origin;European;FAT gene;Financial Hardship;Frequencies;Genes;Genetic;Genetic Predisposition to Disease;Genetic Variation;genomic data;Genomics;Germ Lines;Head and Neck Cancer;Hispanic;Hispanic Populations;hormone receptor-positive;hormone therapy;Human;improved;In Vitro;individual patient;information gathering;inhibitor;inhibitor therapy;Interview;Malignant Breast Neoplasm;Malignant Neoplasms;markov model;medication compliance;Messenger RNA;Metastatic breast cancer;mRNA Expression;Mutation;Not Hispanic or Latino;novel therapeutic intervention;Oral;Outcome;outcome disparities;patient population;Patients;Pattern;Pharmaceutical Preparations;Population;Population Study;Prevalence;Progression-Free Survivals;Quality of life;Race;racial disparity;RB1 gene;Resistance;Resistance development;resistance mechanism;screening;side effect;social determinants;social health determinants;Social support;statistics;Surveys;targeted treatment;Testing;The Cancer Genome Atlas;therapy resistant;Treatment outcome;treatment site;tumor;United States;Variant;verbal;Woman;Women's mortality;women's outcomes

PROJECT_TITLE: Impact of race and ethnicity on outcomes in patients with hormone receptor-positive breast cancer treated with CDK4/6 inhibitors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PHR: CURED PILOT Project 2 Narrative Recognizing the interconnection between public health and the built environment, this research—about the racial disparities in the association between bladder cancer outcomes and neighborhood socioeconomic characteristics and environmental condition—will contribute to a depth in understanding within the public health community about the ways in which housing is one of the most important social determinants of health outcomes.

PI_NAMEs: PUTLURI, NAGIREDDY  (contact)

PROJECT_TERMS: Address;African American;African American population;American;anti-cancer research;Antineoplastic Agents;Behavior;Biological;Biological Factors;Biology;Biomedical Research;built environment;cancer health disparity;Cancer Patient;Cancer Research Project;carcinogenicity;Carcinogens;Categories;Censuses;Characteristics;Clinical;Collaborations;college;Communities;Community Developments;community engagement;Community Health;Comprehensive Cancer Center;Consent;contextual factors;Cross-Sectional Studies;Cystectomy;Data;Data Set;Development;Disadvantaged;Disease Progression;Disparate;Disparity;DNA;DNA Methylation;drug discovery;Drug Kinetics;Economics;Education;education research;Environment;Environmental and Occupational Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;ethnic minority;Ethnic Origin;European;Event;Exhibits;experience;Faculty;Functional disorder;Genes;Geographic Information Systems;Health;health care availability;health data;health disparity populations;Health Services Accessibility;Historically Black Colleges and Universities;Housing;Human;Incidence;Individual;Industry;Inferior;Infrastructure;Institution;Intervention;Interview;Interviewer;Joints;Life Cycle Stages;Link;Lived experience;Location;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Medicine;member;Methylation;methylation pattern;Minority Groups;Modification;Molecular and Cellular Biology;mortality;neighborhood disadvantage;Neighborhoods;Neoplasm Circulating Cells;Neoplasm Metastasis;Occupational;Occupational Exposure;Outcome;Outcome Measure;outreach;Pathway interactions;Patients;Persons;Pilot Projects;Plants;Play;Policies;Policy Research;Printing;Prognostic Marker;programs;Public Health;Race;racial disparity;racial minority;Recording of previous events;recruit;Reporting;Research;Resource Sharing;Risk;Role;Rubber;Running;Smoking History;social culture;Social Environment;social factors;social health determinants;socioeconomics;software systems;Source;Specimen;stressor;Surveys;Testing;Texas;Textiles;timeline;Tissue Sample;tumor;Tumor Bank;tumor progression;U.S. Department of Housing and Urban Development;Universities;Work;Workplace;Xenobiotics

PROJECT_TITLE: Racial and social contextual factors in relation to epigenome and bladder cancer outcome.


NIH_SPENDING_CATS: Aging;Genetics

PHR: Narrative Historically ribosomes were believed to translate whatever transcript they were presented with, but recent studies suggest that ribosome composition varies and plays a significant role in the regulation of translation. This proposal will provide insight into how methylation of ribosomal RNA changes with age to produce specialized ribosomes to control the translation of specific transcripts in response to environmental stressors and organismal aging. We have found that methylation of 18S ribosomal RNA plays a crucial role in regulating longevity and the stress response in C. elegans and propose to identify the molecular basis by which methylation of rRNAs specify distinct translational outcomes in response to environmental stimuli.

PI_NAMEs: GREER, ERIC LIEBERMAN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adenosine;Affect;Age;age acceleration;age related changes;Aging;aging process;Animals;Binding;Biochemical;Biological;biological adaptation to stress;Caenorhabditis elegans;Cells;Complex;Cues;Data;DNA Methylation;environmental stressor;Enzymes;Eukaryota;Event;experimental study;follow-up;gene product;Genetic;Goals;hallmarks of aging;Health;healthy aging;Heat-Shock Response;Heterogeneity;Immunoprecipitation;In Vitro;in vivo;insight;Longevity;Maintenance;Messenger RNA;Metabolism;Methylation;Methyltransferase;Modification;Molecular;mRNA Translation;mutant;Organism;Outcome;Pathway interactions;Play;polysome profiling;preservation;Process;Protein Biosynthesis;Proteins;Proteome;Regulation;Resistance;response;Ribosomal DNA;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;RNA interference screen;RNA methylation;RNA, Ribosomal, 18S;Role;Signal Pathway;Specific qualifier value;Specificity;Stimulus;Stress;Structure;Testing;Tissues;Transcript;transcriptome;Transgenic Organisms;Translating;Translational Regulation;Translational Repression;Translations;ultraviolet irradiation;Work

PROJECT_TITLE: Ribosomal RNA Methylation Regulation of Longevity and Stress Resistance

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


PHR: CURED C-REP Project Narrative The CURED C-REP will provide an 8-weeks mentored cancer research experience that integrates Baylor College of Medicine (BCM) and Texas Southern University (TSU) infrastructures every summer followed by year- long culturally congruent outreach education activities that will increase the awareness, knowledge, and understanding of research, concepts, processes, and careers in cancer research/cancer health disparities a cohort of 20 underrepresented minority students from TSU. The proposed CURED C-REP will enhance cancer research education capacity at TSU, promote the diversity of the cancer research workforce and improve BCM’s effectiveness in developing and sustaining research programs focused on cancer health disparities.

PI_NAMEs: HUANG, SHIXIA  (contact)

PROJECT_TERMS: Address;Advertisements;anti-cancer research;Awareness;Biomedical Research;Cancer Center;cancer education;cancer health disparity;career;Career Choice;Career Mobility;Clinical;Clinical Research;cohort;Collaborations;college;Communication;Communities;community engagement;Complex;Comprehensive Cancer Center;Core Facility;County;Dedications;design;Development;Disparity;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Effectiveness;Environment;Event;experience;Faculty;Fellowship;Future;Goals;Health Disparities Research;health disparity populations;Health Services;Healthcare;Historically Black Colleges and Universities;Hour;improved;Incidence;Infrastructure;innovation;Institution;interest;Knowledge;Laboratories;Malignant Neoplasms;Mass Media;Medical center;Medicine;member;Mentors;Mentorship;Minority Groups;minority trainee;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;novel;outreach;Pharmacology;Pharmacy facility;Pilot Projects;Postdoctoral Fellow;Printed Media;Process;programs;racial diversity;Records;recruit;Research;Research Infrastructure;Research Personnel;Residencies;Science;skills;social media;Students;summer program;summer research;symposium;Technology;Texas;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student

PROJECT_TITLE: BCM-TSU CURED Cancer Research Education Program (C-REP)