NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE HIV and cervical cancer severely impact racial and ethnic minorities in Georgia, particularly Black women living with HIV (WLWH). The Georgia Consortium to Eliminate Cervical Cancer in Women Living with HIV maximizes the collaborative strengths of Emory’s high-impact HIV research and clinical network and Morehouse School of Medicine’s strong community and clinical partnerships by engaging a diverse array of community members who serve WLWH. This unique setting of multidisciplinary partners will provide the ‘CASCADE’ Network with valuable information on the clinical effectiveness and scalability of interventions aimed at improving cervical cancer prevention in WLWH.

PI_NAMEs: FLOWERS, LISA C. (contact);SHETH, ANANDI NAYAN

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adverse event;Advocacy;Affect;Area;black women;Cancer Center;cancer risk;Caring;cervical cancer prevention;Cervical Cancer Screening;Client;Clinic;Clinical;clinical care;Clinical effectiveness;clinical infrastructure;Clinical Research;clinical research site;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Colposcopy;Communicable Diseases;Communities;community advisory board;community clinic;community engagement;Community Networks;community organizations;community partners;community partnership;cultural competence;data quality;deprivation;design;Disproportionately impacts women;diversity and equity;Eligibility Determination;Enrollment;Ensure;Environmental Risk Factor;Equity;ethnic minority;experience;Feedback;follow-up;Funding;Geographic Locations;Goals;Gynecologist;Gynecology;health care availability;health communication;health disparity;Health Services Accessibility;Health system;Healthcare Systems;HIV;HIV diagnosis;HIV Infections;Hospitals;Human Papillomavirus;human subject;implementation science;improved;indexing;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;member;Mentors;mHealth;Morehouse School of Medicine;mortality;multidisciplinary;Outcomes Research;Participant;participant retention;patient navigation;Persons;Population;Population Heterogeneity;Positioning Attribute;Poverty;Pragmatic clinical trial;Prevalence;Prevention;prevention service;Procedures;programs;Protocols documentation;racial minority;recruit;Reporting;reproductive outcome;Research;Research Infrastructure;Research Personnel;research study;Resources;retention rate;Risk;Rural;rural area;Rural Community;rural counties;rural setting;screening;screening guidelines;screening program;Services;Site;social health determinants;Socioeconomic Factors;Structure;Training;Travel;Treatment outcome;underserved area;Universities;Urban Community;urban setting;White Women;Woman;women's diagnosis;Women's Health;Women's Interagency HIV Study;women's prevention;women's treatment;Work

PROJECT_TITLE: Georgia Consortium to Eliminate Cervical Cancer in Women Living with HIV (GaCECC-WLWH)


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The T32 Colorado Training Program is designed to provide our Trainees with a comprehensive, integrative, and formal career development experience with the goal of positioning them to become the next generation of leaders in Pulmonary and Critical Care Medicine. Key outcomes for the CTP program will be the success rate of Trainees, including retention in academic positions, securing career development awards, high-quality peer- reviewed publications, development of intellectual property, and alignment with values of academic medicine.

PI_NAMEs: BURNHAM, ELLEN L;MAIER, LISA A;PETRACHE, IRINA ;SCHWARTZ, DAVID ALBERT (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Interdisciplinary Study;Research Training;Respiratory Disease

PROJECT_TITLE: Multi-Disciplinary Research Training in Respiratory Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: BASSIK, MICHAEL C (contact)

PROJECT_TERMS: 3-Dimensional;adaptive immune response;anti-cancer;anticancer activity;biomarker driven;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer progression;Breast Cancer Risk Factor;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Candidate Disease Gene;candidate identification;CD47 gene;Cell Communication;Cell Line;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Dependence;Development;differential expression;Drug resistance;Drug Targeting;druggable target;Effectiveness;Engineering;Estrogen receptor positive;Exhibits;experimental study;Fluorescent Probes;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Growth;high risk;hormone therapy;Immune Evasion;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;Macrophage;Magnetism;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mass Spectrum Analysis;MCF10A cells;MCF7 cell;Measurement;Measures;Mediating;Metastatic breast cancer;Modeling;Molecular;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Organoids;Outcome;overexpression;Patients;Phagocytes;Phagocytosis;Phenotype;Post-Translational Protein Processing;Process;Property;Proteins;Proteomics;receptor;Relapse;relapse risk;Repression;Resistance;Resistance development;resistance mechanism;Role;sialylation;Signal Transduction;spheroids;Subgroup;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;three dimensional cell culture;transcriptomics;Trastuzumab;treatment response;tumor;Tumor Escape;tumor initiation;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenesis

PROJECT_TITLE: Project 3: Systematic characterization of factors controlling breast cancer progression and resistance


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Oxidative DNA damage at telomeres induced by radiation or other stresses is a source of genomic instability, which fuels both aging and tumorigenesis. We have discovered a new DNA repair pathway that protects cells against telomeric oxidative damage and found it remarkably similar to the alternative lengthening of telomere (ALT) pathway used by cancer cells to maintain telomeres. We will molecularly delineate this repair pathway, understand its relationship to ALT, and develop strategies to selectively kill cancer cells reliant on these pathways, bringing a new front to the interface of aging and cancer research.

PI_NAMEs: LAN, LI  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Aging;anti-cancer research;Bypass;cancer cell;cancer type;cell age;Cell Aging;Cell division;Cells;Chemicals;clinical investigation;Cockayne Syndrome;coping;Critical Pathways;Cytoprotection;Dependence;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair Pathway;DNA replication fork;Future;Genomic Instability;Human;Investigation;Lesion;life span;Link;Malignant Neoplasms;Mediating;Molecular;Mus;novel;oxidative damage;oxidative DNA damage;Pathway interactions;Patients;Phenotype;pre-clinical;Premature aging syndrome;Process;protective pathway;Proteins;RAD52 gene;Radiation;Reactive Oxygen Species;repaired;response;Role;senescence;sensor;Source;Stress;targeted cancer therapy;Telomerase;telomere;telomere loss;Telomere Pathway;Telomere Shortening;Testing;tumorigenesis;Untranslated RNA

PROJECT_TITLE: Understanding and Targeting the R-Loop-Mediated DNA Damage Response at Telomeres

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine;Women's Health Research

PI_NAMEs: BEAN, GREGORY  (contact)

PROJECT_TERMS: Address;Bar Codes;bean;biobank;Biological Assay;biomarker driven;Biopsy;Blood;Blood specimen;Breast;breast cancer metastasis;Breast Cancer Patient;breast cancer survival;Breast Oncology;Cancer Relapse;Cell Survival;Cellularity;Clinical;Clinical Data;clinical trial recruitment;Clinical Trials;clinically relevant;cohort;Consent;Correlative Study;Cryopreservation;Data;Databases;design;Diagnosis;Disease;Disease Progression;Distant Metastasis;Early treatment;electronic data;Emergency Department patient;ERBB2 gene;Estrogen receptor positive;Evolution;experience;follow-up;Formalin;Generations;Genomics;Goals;high risk;Immune;Immunohistochemistry;improved;insight;Institutional Review Boards;Laboratories;Link;Location;Longitudinal cohort;Longterm Follow-up;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammary Neoplasms;Management Information Systems;Medical Oncologist;Metadata;Metastatic breast cancer;metastatic process;Modernization;Molecular;multidisciplinary;multiple omics;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;new therapeutic target;novel therapeutic intervention;Oncology;Organoids;Outcome;Pathologic;Pathologist;Pathology;Patient Recruitments;Patients;Pattern;Phase Ib Trial;Phase II Clinical Trials;preservation;Principal Investigator;Procedures;Process;prospective;Proteomics;Protocols documentation;Qualifying;Quality Control;Recurrence;Relapse;relapse risk;Research;Research Personnel;Resolution;routine care;sample collection;sample fixation;Sampling;Scanning;Secure;Site;Slide;Source;spatiotemporal;Specimen;Standardization;Subgroup;Surgeon;Survival Rate;therapy resistant;Tissue Banks;Tissue Microarray;Tissues;transcriptomics;Translational Research;triple-negative invasive breast carcinoma;tumor;Tumor Markers;Tumor Tissue;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Core 1: Stanford Breast Metastasis Center Biospecimen and Pathology Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Microbiome;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The precursor phase of multiple myeloma (MM), smoldering MM, is increased in African Americans (AA) leading to an increased incidence of active MM requiring therapy, therefore, understanding early molecular events is critical to establish why this racial disparity occurs. Chronic inflammation is linked with MM in European Americans and our preliminary data has identified an immune mutational signature, active in early pre-clinical disease phases that is increased in AA, and could explain the AA excess risk. By extracting these early mutational signatures from whole genome sequencing data of bone marrow samples along with assessments of the immune microenvironment and the gut microbiome we aim to establish a link that could be manipulated to minimize racial disparities in this devastating cancer. 1

PI_NAMEs: MORGAN, GARETH JOHN (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adenine;Affinity;African American;African American population;Age of Onset;Alabama;American;anti-cancer research;Antigens;biobank;Biocompatible Materials;Biological;Biometry;Bone Marrow;Cancer Center;Chronic;Chronology;Clinical;Collection;Comprehensive Cancer Center;Computational algorithm;Cross-Sectional Studies;Data;Data Set;Deaminase;Disease;Disparity;DNA;early onset;effective intervention;Environment;Environmental Exposure;Epidemiology;Etiology;European;Event;Exposure to;Fingerprint;Generations;Genetic;Genetic Predisposition to Disease;genetic variant;genome sequencing;Genomics;Goals;gut microbiome;gut microbiota;high risk;Immune;Immune response;immunological status;Immunologics;Immunosuppression;Incidence;Indiana;Individual;Induced Mutation;Inflammation;Infrastructure;insight;Intervention;Knowledge;Link;Longitudinal cohort study;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;microbiome;Molecular;Molecular Abnormality;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;Mutation;New York;Pathogenesis;Pathologic Mutagenesis;Phase;Play;pre-clinical;premalignant;Process;Prospective, cohort study;Race;racial difference;racial disparity;racial diversity;racial population;Reaction;reconstruction;response;Risk;Role;Sampling;Series;Shapes;Structure of germinal center of lymph node;System;T cell response;T-Lymphocyte;Therapeutic;Time;tumor-immune system interactions;Universities;whole genome

PROJECT_TITLE: Mutographs differentiating the racial and temporal incidence of multiple myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

PI_NAMEs: KUO, CALVIN J (contact)

PROJECT_TERMS: 3-Dimensional;Address;Air;anti-cancer research;biobank;Breast;breast cancer genomics;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Cancer Biology;Cancer Relapse;cancer subtypes;Carcinoma;Cell Communication;Cell Line;cell type;Cells;Characteristics;Clinical;Clinical Pathology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Consent;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cryopreservation;Development;digital;Disease;Drug Modelings;Drug resistance;Drug Targeting;Epithelial Cells;Epithelium;Experimental Models;Feedback;functional genomics;Genes;Genetic;Genetic Engineering;genome sequencing;Genomics;glycosylation;Goals;Heterogeneity;Histologic;Histology;Human;Immune;Immune Evasion;Immunological Models;Impairment;in vitro Model;Information Dissemination;Liquid substance;Macrophage;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;mammary;Mediating;Metastatic breast cancer;Methods;Modeling;molecular subtypes;Mus;Mycoplasma;nano-string;Neoplasm Metastasis;next generation;novel;Occupational activity of managing finances;Organoids;Pathology;patient derived xenograft model;Patients;Pattern;Phagocytosis;Pharmaceutical Preparations;Physiological;Population;Positioning Attribute;Primary Neoplasm;Production;Property;Proteomics;Protocols documentation;Qualifying;Quality Control;reconstitution;Research;Research Personnel;Resources;response;Services;single-cell RNA sequencing;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Standardization;Study models;synergism;System;Technology;Testing;therapeutic target;therapy resistant;Tissues;tool;transcriptome;tumor;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;whole genome;Work

PROJECT_TITLE: Core 2: Stanford Breast Metastasis Center Organoid Core


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Despite the on-going serious obesity epidemic, genetic factors, gene-environment and gene-sex interactions as well as biological mechanisms driving obesity-related health-to-disease transitions towards manifestation of obesity-induced cardiometabolic disorders (CMDs) have remained largely elusive, leaving a significant number of individuals without proper prevention and care. To address these pressing medical knowledge gaps, we propose to 1) elucidate epigenetic and transcriptional markers for health-to-cardiometabolic disease transitions in males and females; and 2) discover gene-environment and gene-sex interactions for health-to-CMD transitions using a new function-to-variants omics approach and its follow-up in extensive biobanks. Overall, our health-to- CMD approach has a great potential to help prevent CMDs and delay their onset.

PI_NAMEs: PAJUKANTA, PAIVI  (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Aorta;ATAC-seq;Automobile Driving;biobank;Biological;Biological Assay;Biological Markers;Biomedical Research;Body mass index;candidate identification;Cardiometabolic Disease;cardiometabolism;Caring;Cell Nucleus;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Data;Deterioration;Diabetes Mellitus;Disease;disorder risk;Environment;Environmental Risk Factor;epidemiology study;Epigenetic Process;epigenomics;experience;Fatty acid glycerol esters;Female;follow-up;functional genomics;gene discovery;gene environment interaction;Gene Expression;Genes;Genetic;genetic linkage analysis;Genetic Transcription;Genome;genome wide association study;genomic data;Genomics;Genotype;global health;Health;Health Transition;High Fat Diet;High Prevalence;Human;Individual;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;Knowledge;Ligands;Link;lipid biosynthesis;Lipids;Liver;male;Maps;Mediating;Medical;Mendelian randomization;Metabolic;Mexican;Molecular;multimodality;multiple omics;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Normal tissue morphology;Obesity;Obesity Epidemic;Overnutrition;Overweight;personalized strategies;Phenotype;polygenic risk score;Population Heterogeneity;prevent;Prevention;Protein Secretion;Publishing;Regulatory Element;Reporter;response;risk variant;RNA Sequences;Role;Running;Sampling;Serum;sex;Sex Differences;Sex Factors;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Small Interfering RNA;Stimulus;subcutaneous;Testing;Thinness;Time;Tissue Sample;Tissues;trait;transcriptome sequencing;transcriptomics;TREM2 gene;Variant;Visceral;Weight

PROJECT_TITLE: Multimodal omics approach to identify health to cardiometabolic disease transitions

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE As genomic sequence data are being produced faster and at lower cost, the most significant challenge in clinical genetic testing today is accurate variant classification and communication of that information to patients which is being adversely affected by variants of unknown significance (VUS), which comprise of a substantial percentage of all genetic variants in clinical oncology. VUS along with other confirmed variants are being reclassified with increasing availability of more ethnically diverse reference data, yet there is a lack of understanding on how practicing clinicians, and patients are impacted by and manage these variants. To provide empirical data to fill this critical knowledge gap and potentially inform patient care, I will conduct a national survey of oncology providers about how their variant reclassification related practices, develop a tool for measuring patient reported uncertainty in genomics, and evaluate the clinical utility of VUS reclassification among cancer patients and at-risk individuals.

PI_NAMEs: MAKHNOON, SUKH  (contact)

PROJECT_TERMS: Affect;Anxiety;apprenticeship;Award;Behavioral;Cancer Patient;cancer prevention;career;Classification;Clinical;clinical decision-making;Clinical Investigator;Clinical Oncology;clinical translation;clinically relevant;clinically significant;cohort;Communication;Comprehensive Cancer Center;Computerized Medical Record;Confusion;cost;Data;Decision Making;Dedications;design;Development;Diffuse;Dimensions;DNA Sequence Alteration;Early Diagnosis;Early treatment;Ensure;ethnic diversity;ethnic minority population;evidence based guidelines;experience;Foundations;Frequencies;Fright;Funding;Future;Genetic Services;genetic technology;genetic testing;genetic variant;genome sequencing;Genomic medicine;Genomics;Germ Lines;Goals;Guidelines;Health;Health system;Healthcare Systems;Human;improved;Individual;Institutional Practice;instrument;Intervention;Interview;Investigation;Knowledge;Length;Literature;Longitudinal Studies;Malignant Neoplasms;Measures;Medical;Medical Genetics;Mentorship;Methods;Minority Groups;mutation carrier;novel;Oncology;Operative Surgical Procedures;Outcome;Patient Care;Patient Outcomes Assessments;patient population;Patients;Perception;Phase;Practice Guidelines;Prevalence;Professional Practice;Program Sustainability;Provider;Psychometrics;psychosocial;psychosocial outcome;psychosocial wellbeing;Public Health Informatics;Qualitative Methods;racial diversity;racial minority population;Recommendation;Recontacts;Reporting;Research;Risk;Sampling;screening;Site;sociodemographics;Source;Structure;Subgroup;Surgical Management;Survey Methodology;Surveys;Test Result;Testing;therapy design;Time;tool;Training;translational genomics;Uncertainty;Underrepresented Minority;Underserved Population;United States;Update;Validation;Variant;variant of unknown significance;Work

PROJECT_TITLE: Multilevel investigation of uncertain and reclassified genomic variants in clinical oncology


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Rare Diseases;Scleroderma;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Systemic Sclerosis (SSc) is an inflammatory-driven multi-system fibrotic disease impacting morbidity, mortality, and quality of life. We have identified Hippo-signaling as a critical circuit in SSc pro-fibrotic processes in promoting endothelial-mesenchymal (Endo-MT) and fibroblast-to-myofibroblast transition. Here, we will mechanistically dissect the role of the Hippo pathway in SSc and the contribution of LAMP3+ Dendritic Cells.

PI_NAMEs: GUDJONSSON, JOHANN ELI (contact);KHANNA, DINESH ;TSOU, PEI-SUEN

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Autoimmunity;Binding;Biological Assay;Biological Markers;Biological Process;Blood;Blood Vessels;Cell Communication;Cell Nucleus;cell type;Cells;ChIP-seq;Choristoma;Coculture Techniques;cofactor;Collagen Type I;Complex;crosslink;Cutaneous;Cutaneous sclerosis;Cytoplasm;Data;Dendritic cell activation;Dendritic Cells;Deposition;Differentiation Antigens;Diffuse;Disease;Disproportionately impacts women;DNA Binding;EGF gene;Endothelial Cells;Endothelium;Extracellular Matrix;Female;Fibroblasts;Fibrosis;Genes;Genetic Predisposition to Disease;Genetic Transcription;Immune;immune function;Immune system;Inflammation Mediators;Inflammatory;innovation;LAMP3 gene;Licensing;Ligands;Mass Spectrum Analysis;Mesenchymal;Morbidity - disease rate;mortality;Myeloid Cells;Myofibroblast;notch protein;novel;Nuclear;Organ;Pathogenesis;Pathway interactions;Patients;Phenotype;Platelet-Derived Growth Factor;Population;Process;Profibrotic signal;Quality of life;receptor;response;Role;Scleroderma;Sex Bias;Signal Pathway;Signal Transduction;single cell sequencing;Skin;Small Interfering RNA;Source;Stromal Cells;System;Systemic Scleroderma;TGFB1 gene;transcription factor;transcriptome sequencing;Vascular Diseases;Vascular Endothelial Growth Factors;Women's Role;Work

PROJECT_TITLE: Role of the Hippo pathway in scleroderma pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-H (02)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE It is becoming increasingly evident that changes in how molecules, cells and tissues respond to forces are linked to many diseases, such as cancer, cardiovascular diseases, muscular dystrophies, asthma, fibrosis, osteoarthritis and connective tissue disorders. Mechanobiology focusses on understanding these changes and at developing mechanodiagnostic and mechanotherapeutic approaches while mechanochemistry is dedicated to engineering mechanoresponsive materials for tissue regeneration. The 2024 Multiscale Mechanochemistry and Mechanobiology Gordon Research Conference and Seminar will serve as a platform for interdisciplinary scientific discourse, uniting experts and trainees in the aforementioned domains to drive the translation of fundamental insights into biomedical applications.

PI_NAMEs: BLANK, KERSTIN G. (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Achondroplasia, the most common form of short stature in humans, is due to variants in FGFR3 that over- activate the fibroblast growth factor receptor 3 and thereby severely impair the specific activities of cartilage growth plate cells. This project is designed to increase current knowledge of the mechanisms controlling FGFR3 expression in these cells and affecting them downstream of FGFR3 in achondroplasia. The ultimate goal is to propose novel strategies, whereby the targeting of these mechanisms would provide direly needed, safe and effective treatments for people with achondroplasia and related conditions.

PI_NAMEs: LEFEBVRE, VERONIQUE M (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Achondroplasia;Address;Affect;Alleles;bone;Cartilage;catalase;cell type;Cells;Cellular Metabolic Process;Chondrocytes;chondrodysplasia;Climacteric;Clinical;craniofacial;CRISPR/Cas technology;Critical Pathways;Data;Defect;design;Development;Disease;Distal;effective therapy;Engineering;Enhancers;Ensure;Epigenetic Process;Epiphysial cartilage;Extracellular Matrix;Face;Failure;FGFR3 gene;frontier;gain of function;Genetic;genome-wide;Glycolysis;Goals;Growth;Heterozygote;HIF1A gene;Human;Hypoxia;Impairment;In Situ;In Vitro;in vivo;Individual;innovation;Knowledge;Lifting;Lightning;Limb structure;Link;long bone;Lordosis;loss of function;Malignant Neoplasms;Mediating;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;Mus;Neurologic;Neurologic Symptoms;novel;novel strategies;Operative Surgical Procedures;Outcome;Oxidative Stress;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;Pilot Projects;Post-Translational Protein Processing;Pre-Clinical Model;premature;Prevalence;Production;programs;Proliferating;Publishing;Reactive Oxygen Species;Regulation;Regulatory Element;Reporter;Research;Resolution;Role;Severities;short bone;skeletal;Skeleton;skull base;Solid;spine bone structure;Stenosis;Syndrome;Testing;Text;Therapeutic;Time;tool;transcription factor;transcriptomics;Transgenes;Transgenic Mice;Transgenic Organisms;translational impact;Variant

PROJECT_TITLE: FGFR3 Activities in the Control of Skeletal Growth

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Changes in the curvature of cell membranes are important for the morphology and motility of cells. These functions are disrupted in many diseases including developmental disorders and cancer. Here we will establish an in vivo model to test the physiological significance of the structural domains of a peripheral membrane protein of the BAR family that changes membrane curvature. Furthermore, we will use protein structure methods to solve its structure. Data originated here will advance our understanding of how cells regulate morphology and motility in health and disease.

PI_NAMEs: BIANCHI, LAURA  (contact);MIM, CARSTEN

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Amino Acids;amphiphysin;Animal Behavior;Behavioral Assay;Binding;Binding Proteins;Caenorhabditis elegans;cancer therapy;CDC42 gene;Cell membrane;Cell Mobility;cell motility;Cell Physiology;Cell Shape;Cells;Cellular Morphology;Complex;Confocal Microscopy;Coupling;Cryoelectron Microscopy;Cytoskeleton;Data;design;developmental disease;Disease;Endocytosis;Etiology;experience;Family;Fluorescence Microscopy;Foundations;Future;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Homologous Gene;Homologous Protein;Human;Image;Immunologic Deficiency Syndromes;in vivo;in vivo evaluation;in vivo Model;Investigation;knock-down;Knowledge;Length;Malignant Neoplasms;Membrane;Membrane Biology;Membrane Proteins;Methods;Modeling;Molecular Conformation;Monomeric GTP-Binding Proteins;Morphology;Motility;Mutation;nano;Nerve Degeneration;Nervous System Physiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;novel;Organelles;Organism;Peripheral;Phenotype;Physiological;polymerization;Polymers;Positioning Attribute;Process;Protein Family;protein function;protein structure;Proteins;recruit;Research Personnel;Resolution;response;rho GTP-Binding Proteins;Role;Sampling;Sensory;structural biology;Structure;targeted treatment;Techniques;Testing;TRIP10 gene;Work;Yeasts

PROJECT_TITLE: Role of TOCA proteins in glia: from cellular morphology to animal behavior

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Estrogen

PHR: Project Narrative The 14th Gordon Research Conference on Environmental Endocrine Disruptors will bring together basic and translational scientists, clinicians, and public health advocates across scientific disciplines to increase collaboration and discussions to foster cross-fertilization in the field. The theme of this conference, the impact of environmental endocrine disruptors on planetary health and planetary boundaries, will allow researchers to present cutting-edge results, illustrating the depth and breadth of the field, in a way that is accessible across disciplines. The primary objective of this conference is to remain the preeminent place for researchers at every career stage to learn about the latest advancements and exchange scientific ideas relevant to the endocrine disruptors.

PI_NAMEs: VANDENBERG, LAURA N. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Academia;Address;Adverse effects;Advocate;Affect;Air;Animals;Area;Biodiversity;career;Career Choice;chemical release;Coin;Collaborations;Complement;consumer product;Data;Decision Making;design;Developmental Biology;Diabetes Mellitus;Discipline;Disease;doctoral student;Dust;Ecology;Ecosystem;educational atmosphere;Endocrine Disruptors;Endocrinology;Environment;Environmental Impact;Epidemiology;epidemiology study;Etiology;exposed human population;Exposure to;Feedback;Fertilization;Food;Fostering;Funding;Generations;Goals;Government;Health;Hormones;Human;human disease;Humanities;Immune system;improved;Individual;Industry;International;Italy;Knowledge;Laboratory Study;Lead;Learning;Link;Location;Malignant Neoplasms;marine;medical specialties;meetings;member;Methods;Molecular Biology;neurodevelopment;Neurosciences;Neurosecretory Systems;novel;Obesity;Participant;Physiology;Policy Maker;Population;Postdoctoral Fellow;posters;Primary Prevention;programs;Public Health;remediation;Renaissance;reproductive system disorder;Request for Applications;Research;Research Personnel;Resort;Risk;Role;Science;Scientist;Soil;supportive environment;symposium;Thinking;Thyroid Gland;Time;Toxicology;translational scientist;Uncertainty;Water;Work

PROJECT_TITLE: 2024 Environmental Endocrine Disruptors Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (R3)]


ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Current surgical options for intractable epilepsy result in continued seizures in 30-60% of cases. New research, including our own, suggests that quantitative analysis of the interictal EEG — time periods between seizures — can localize seizure generators and may help improve surgical planning. The goals of this study are to determine the spatiotemporal characteristics of two alternate quantitative methods of analyzing interictal EEG, to test whether these methods accurately localize seizure generators, and to determine if probing the interictal EEG with electrical stimulation improves localization.

PI_NAMEs: CONRAD, ERIN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TITLE: Quantitative interictal networks to localize seizure generators


NIH_SPENDING_CATS: Infectious Diseases

PHR: Project Narrative The 2024 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Microbial Toxins and Pathogenicity are the premiere events that showcase exciting, innovative basic and applied research in the field of infectious disease. The GRC and GRS promote open discussions and active networking between new and veteran researchers from academia and government, medicine and biotech. In addition to providing an exceptional forum for a diverse community of scientists to learn and discuss the latest discoveries in the field, the GRC and GRS provide exceptional opportunities for the professional development of the next generation of researchers and promotes their success within the broader scientific community.

PI_NAMEs: O'RIORDAN, MARY  (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Academia;Academic Medical Centers;Address;Applied Research;Area;Bacterial Physiology;Bacterial Toxins;Basic Science;Biochemistry;Biotechnology;career;career development;Cellular biology;Clinical Medicine;Clinical Research;Collaborations;Communicable Diseases;Communities;Companions;Department chair;design;Detection;Development;Developmental Biology;Discipline;Disease;DNA Sequence Analysis;Doctor of Philosophy;Event;Evolution;Face;Faculty;Fostering;Genetic;genome analysis;Goals;Government;Health;host-microbe interactions;Hour;Human;Image;Immunology;Infection;Innate Immune Response;innovation;International;Knowledge;Lead;Learning;Lived experience;marginalized population;Medical center;medical schools;Medicine;Mentors;Metabolism;Michigan;Microbe;microbial;Microbiology;microbiome;Molecular;Molecular Biology;New Hampshire;next generation;novel strategies;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pennsylvania;Physiology;Population;Population Heterogeneity;Postdoctoral Fellow;posters;pre-doctoral;professor;Regulation;Research;Research Personnel;Resort;Saint Jude Children's Research Hospital;Science;Scientist;Senior Scientist;success;symposium;Toxin;Training;Underrepresented Populations;Universities;Veterans;Virulence;Woman;Work

PROJECT_TITLE: 2024 Microbial Toxins and Pathogenicity Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE With the newly generated multi-tissue DNA methylation data from the Genotype-Tissue Expression (GTEx) project, we propose to develop methods for integrating multi-tissue methylation QTLs (mQTLs) with multi-tissue eQTLs to improve the mapping of QTLs with co-occurring effects; and we extend the method to multi-cell-type single-cell QTL mapping with the integration of bk-QTL statistics, and trans-ethnic disease-relevant supervised QTL mapping. Moreover, motivated by the shared genetic regulation of cis-expression and methylation levels, we propose a multivariable Mendelian randomization framework for analyzing multi-tissue expression and methylation as joint risk exposures for complex diseases. We will develop scalable software for the proposed methods, will analyze GTEx, sc-eQTLGen data and multiple GWASs to map QTLs and identify risk genes, and will use additional e/mQTL and sc-eQTL data to replication and validate our results.

PI_NAMEs: CHEN, LIN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Accounting;Address;Affect;Alzheimer's Disease;Brain Diseases;Brain Mapping;Cardiovascular Diseases;cell type;Cells;Complement;Complex;Computer software;Data;Data Analyses;Data Sources;Detection;Development;Disease;disorder risk;DNA Methylation;Ethnic Origin;Exposure to;Gene Expression;Genes;Genetic;Genetic study;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Heterogeneity;Human;human tissue;improved;innovation;insight;instrument;Joints;Link;Maps;Measures;member;Mendelian randomization;method development;Methods;Methylation;methylome;Modeling;molecular phenotype;multiple omics;Pattern;Predisposition;Quantitative Trait Loci;Regulation;Resolution;Resources;Risk;Risk Factors;risk variant;Sampling;software development;Source;statistics;supervised learning;Testing;Tissues;trait;transcriptome;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Integrative multivariate association and genomic analyses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-A (02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Cerebral amyloid angiopathy (CAA), a common finding in over 90% of Alzheimer's disease (AD) cases, is characterized by the deposition of amyloid in the cerebrovascular compartment. This overlap between AD and vascular brain pathology in dementia has been difficult to separate, with AD and vascular dementia probably existing as a continuum of distinct but mechanistically related processes. The studies outlined in this proposal will allow us to dissect in detail the mechanisms by which CAA leads to cognitive decline and may identify novel therapeutic targets for CAA and AD.

PI_NAMEs: LASAGNA-REEVES, CRISTIAN  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Affect;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid peptide;Amyotrophic Lateral Sclerosis;Astrocytes;Autopsy;Behavioral;behavioral phenotyping;Biochemical;Blood Vessels;Brain;Brain Pathology;C3AR1 gene;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Complement 3;Complement Activation;complement pathway;complement system;Complex;Data;Dementia;Deposition;Development;digital;Disease;Electrophysiology (science);Environment;Exposure to;extracellular;Functional disorder;Heterogeneity;Histologic;Homeostasis;Human;hyperphosphorylated tau;Image;Immune response;Impaired cognition;Impairment;in vivo;in vivo Model;Individual;Inflammation;Knockout Mice;Link;LoxP-flanked allele;Microglia;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neuroprotection;neurotoxic;new therapeutic target;novel;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Phenotype;Play;Population Heterogeneity;Positioning Attribute;Prion Diseases;Probability;Process;Proteins;Reporting;Research;Role;Sampling;Senile Plaques;Series;single nucleus RNA-sequencing;spatial integration;Synapses;Tamoxifen;tau aggregation;tau expression;tau Proteins;Testing;therapeutically effective;Tissues;transcriptomics;Up-Regulation;vascular contributions;Vascular Dementia

PROJECT_TITLE: CAA, Tau and Neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (55)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The proposed research is relevant to public health because it transforms free-text clinical evidence in the literature into a computable format that can better support evidence extraction and summarization. It applies natural language processing to unstructured biomedical literature to support evidence-based clinical research and to enhance the health of the public. The proposed research is also relevant to the part of the NLM's strategic plan that focuses on (1) development and demonstration of innovative informatics methods and data science techniques for informing public health, (2) advanced information retrieval and knowledge discovery from very large and/or heterogeneous data sets

PI_NAMEs: PENG, YIFAN  (contact);WENG, CHUNHUA

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Affect;Age;cardiovascular health;Clinical;clinical care;Clinical Research;Clinical Trials;cohort;Cohort Studies;comparative efficacy;Complex;cost;Data;Data Science;Decision Making;deep learning;deep learning model;design;Development;Elements;empowerment;evidence base;Evidence Based Medicine;experience;Financial cost;fitness;gastrointestinal system;General Population;Grain;Guidelines;Health;Healthcare;heterogenous data;Human;improved;indexing;Informatics;Information Retrieval;innovation;Intervention;Intervention Studies;Journals;Judgment;Knowledge;Knowledge Discovery;learning strategy;Linguistics;Literature;Manuals;Measurement;Measures;Medical;Memory;Mental Health;Meta-Analysis;Methods;Modeling;Natural Language Processing;Neurologic;novel;Observational Study;Ontology;Outcome;Outcome Study;patient population;Peer Review;Persons;Policies;Policy Maker;Population;Process;Public Health;Publications;Publishing;PubMed;Race;randomized, clinical trials;Registries;Reporting;Research;Resources;respiratory;Scientist;societal costs;Socioeconomic Status;Strategic Planning;Structure;success;systematic review;Techniques;Testing;Text;Time;Training;Translations;United States National Aeronautics and Space Administration;United States National Library of Medicine;usability;user centered design;Validation;Visualization;web services;Work

PROJECT_TITLE: Extraction and summarization of evidence-based medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Piezo2 is a non-selective Ca2+ permeable mechanically activated ion channel, that is indispensable for gentle touch and it is involved in injury-induced mechanical pain. We identify a novel lipid regulator of this channel, that inhibits Piezo2, but not Piezo1 activity. Our data will provide insight not how these channels are regulated, and may help identifying selective pharmacological inhibitors of Piezo2 in the future.

PI_NAMEs: ROHACS, TIBOR  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acyltransferase;Affect;Afferent Neurons;alpha-glycerophosphoric acid;analog;Behavior;behavioral response;Binding;Blood Vessels;Cations;Cell division;Cell membrane;Cell Volumes;Cells;Chimera organism;Coenzyme A;Data;Development;Diacylglycerol Kinase;Diglycerides;dimer;Effectiveness;Enzymes;Epithelial Cells;Erythrocytes;Fatty Acids;Future;Glycerol;Goals;Homologous Gene;Human;in vivo;in vivo evaluation;Incubated;inhibitor;Injury;inorganic phosphate;insight;Ion Channel;Knowledge;Lecithin;Length;Lipids;lymphatic vessel;lysophosphatidic acid;mechanical force;Mechanics;Mediating;Membrane;Membrane Lipids;Molecular;Molecular Conformation;monomer;Mus;neural;Neurons;novel;optogenetics;Pain;Pathway interactions;Periodicity;Peripheral;Permeability;pharmacologic;Phosphatidic Acid;Phosphatidylinositols;Phospholipase D;Phospholipids;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Process;Proteins;Regulation;Role;Sensory Process;Shapes;Signal Pathway;Spinal Ganglia;Stretching;structural determinants;Structure;Testing;Touch sensation;Transmembrane Domain;Triglycerides;Vertebral column

PROJECT_TITLE: Regulation of mechanically activated Piezo2 ion channels by membrane lipids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-H (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Pediatric

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project employs state-of-art genetic models and organoid culture to determine the contribution of the yes- associated protein 1 (YAP) to pediatric eosinophilic esophagitis (EoE). This study will advance our understanding of the pathophysiology of pediatric EoE and provide potential therapeutic targets.

PI_NAMEs: BAILEY, DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Albumins;Basal Cell;Basal Cell Hyperplasia;Binding Sites;Biological Assay;Biology;Biopsy;career;career development;Cell Nucleus;Cell Separation;Cellular biology;Child;Childhood;chromatin immunoprecipitation;Chronic;cytokine;Data;Development;Developmental Biology;Disease;disease mechanisms study;early onset;Environment;Eosinophilic Esophagitis;Epithelial Cells;epithelial stem cell;Epithelium;Esophageal Diseases;Esophageal Tissue;Esophagus;experience;experimental study;Flow Cytometry;Foundations;Functional disorder;Future;gain of function;Gastroenterologist;Genetic Models;Genetic Transcription;Goals;healthcare burden;Histologic;Human;Hyperplasia;Immune;Immunology;in silico;in vitro Assay;in vivo;Incidence;Inflammation;Inflammatory;inhibitor;innovation;insight;Interleukin-13;Interleukin-13 Overexpression;K-Series Research Career Programs;knock-down;loss of function;Luciferases;Mediating;Mediator;Mentors;Mentorship;Modeling;Molecular;Morbidity - disease rate;mouse model;multidisciplinary;Mus;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Organoids;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Physicians;potential biomarker;pre-clinical;programs;Proliferating;Proteins;Research;research and development;Research Design;Research Proposals;Role;Scientist;Signal Pathway;Signal Transduction;skills;small hairpin RNA;STAT6 gene;stem cell biology;System;Testing;therapeutic target;Training;Transcription Initiation Site;Translating;Universities;Verteporfin;Weaning;Work;young adult

PROJECT_TITLE: Molecular Mechanisms of Reactive Epithelial Changes in Pediatric Eosinophilic Esophagitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) (previously known as NAFLD and NASH) are the most common liver diseases and often associated with diabetes and obesity. However, mechanisms underlying these diseases and thus, treatments directly targeting the mechanistic drivers are lacking. As such, this application proposes to study a promising novel small molecule antidiabetic drug candidate and its distinct underlying cellular and molecular mechanisms as a potential novel approach and future therapeutic against these metabolic liver diseases.

PI_NAMEs: HABEGGER, KIRK MICHAEL;SHALEV, ANATH  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Affect;Agonist;Amino Acids;Anti-diabetic Drugs;Anti-Inflammatory Agents;Apoptosis;Binding Proteins;blood glucose regulation;Carbohydrates;Cells;Choline Deficiency;chromatin immunoprecipitation;Cytoprotection;Data;Development;Diabetes Mellitus;Diabetic mouse;Diet;diet-induced obesity;Disease;Down-Regulation;drug candidate;Drug Kinetics;Fatty acid glycerol esters;Fatty Liver;fibrogenesis;Fibrosis;first-in-human;Future;Genes;GLP-I receptor;Glucose;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Histology;Homeostasis;Human;improved;in vivo;Inflammasome;Inflammation;inflammatory marker;inhibitor;insight;Kupffer Cells;lipid biosynthesis;Lipids;Liver;Liver diseases;Liver Dysfunction;Mediating;Metabolic;Metabolic dysfunction;Metabolism;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Monitor;mouse model;Mus;Non obese;non-alcoholic fatty liver disease;non-diabetic;nonalcoholic steatohepatitis;novel;novel strategies;novel therapeutic intervention;Obese Mice;Obesity;Oral;Oxidative Stress;Pathology;Peroxisome Proliferator-Activated Receptors;Persons;Pharmaceutical Preparations;Play;pre-clinical;preclinical safety;Preparation;Process;Protein Deficiency;Reporting;Response Elements;Sampling;Signal Transduction;small molecule;Sodium;Steatohepatitis;symporter;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Thinness;Time;Toxicology;transcription factor;translational impact;TXNIP gene;Work

PROJECT_TITLE: TARGETING MASH WITH NOVEL SMALL MOLECULE TXNIP INHIBITOR

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Immunotherapy;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE Congenital CMV (cCMV) infection affects 1 in 200 liveborn infants in the United States and can cause permanent neurodevelopmental impairments and sensorineural hearing loss, but robust outcome predictors are lacking. Infants have poor antiviral T cell responses to in-utero CMV infection, but instead generate cytotoxic NK cells expressing adaptive-like features that are phenotypically distinct from adult NK cell responses to CMV infection. This project will investigate the immunophenotype and cytotoxic activity of cCMV-induced NK cells using advanced CITE-seq and spectral flow cytometry methods, determine the impact of antiviral treatment upon these NK cells, and investigate the potential relationship between NK cell immunophenotypes and neurodevelopmental outcomes among a large cohort of cCMV infected infants.

PI_NAMEs: SHIMAMURA, MASAKO  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Activated Natural Killer Cell;Adult;Adverse drug effect;Affect;Anti-viral Agents;Anti-viral Response;Anti-viral Therapy;antiviral drug development;Biological Assay;Birth;Blood specimen;Brain Injuries;cell age;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cerebral Palsy;Child;Clinical;Clinical Treatment;cohort;congenital cytomegalovirus;Control Groups;cytokine;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;cytotoxicity;Data;Developmental Delay Disorders;exhaust;exhaustion;fetal;Flow Cytometry;Gene Expression Profile;Genetic Transcription;Hallmark Cell;Hearing;Immune response;Immunophenotyping;improved;in utero;In Vitro;Individual;Infant;infant infection;Infection;Infiltration;Intellectual functioning disability;Intellectual impairment;Intervention;Lead;Measures;Mediating;Methods;mouse model;Natural Killer Cell Immunotherapy;Natural Killer Cells;neonatal infection;neonate;Nervous System Trauma;Neurodevelopmental Disability;Neurodevelopmental Impairment;Neurologic;Neurological outcome;novel;Outcome;outcome prediction;pharmacologic;Phenotype;programmed cell death protein 1;receptor;receptor expression;response;Role;Sensorineural Hearing Loss;seropositive;Severities;T cell response;T-Lymphocyte;Testing;Time;Transcript;transcription factor;treatment and outcome;Umbilical Cord Blood;United States;Valganciclovir;Variant;Viral;Viral Load result;Virus Diseases;Virus Replication;Visual;Whole Blood

PROJECT_TITLE: Adaptive Features of In-Utero Natural Killer Cell Responses to Congenital Cytomegalovirus Infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Naturally-derived nanoparticles, or extracellular vesicles (EVs), have shown potential in healing damaged heart tissue. Yet, delivering these EVs to the injured heart effectively faces challenges: rapid dispersion, limited retention, and invasive injection. Our proposed approach aims to enhance EV accumulation and retention in the heart, offering non-invasive treatment possibilities for heart attack recovery without surgery.

PI_NAMEs: NGUYEN, JULIANE  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Affect;Affinity;angiogenesis;Animal Model;Area;Binding;Biodistribution;Biological;Biological Process;biomaterial compatibility;Cardiac;Cardiac Myocytes;cardiac repair;Caring;Cause of Death;Cells;Cessation of life;Cicatrix;clinical translation;crosslink;density;design;Developed Countries;Diffuse;Disease;dosage;Dose;Drug Kinetics;Echocardiography;effective therapy;effectiveness evaluation;Engineering;Ensure;Exhibits;extracellular vesicles;Face;Family suidae;Formulation;Frequencies;Gene Expression;Goals;healing;Heart;heart damage;Heart failure;heart function;Heart Injuries;heart preservation;Heterodimerization;Human;immune cell infiltrate;immunogenicity;improved;In Situ;Infarction;Inflammation;Inhibition of Apoptosis;Injections;injured;insight;Intravenous;Lead;Leucine Zippers;Ligands;Macrophage;Maximum Tolerated Dose;Mediating;Mesenchymal Stem Cells;Methods;Modeling;Molecular;mouse model;Mus;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardium;nanoparticle;novel;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;porcine model;Preclinical Testing;Property;prototype;Recovery;regenerative therapy;regenerative tissue;Regimen;Research;response;Rodent;Site;stem cells;Surface;System;targeted delivery;Therapeutic;therapy outcome;Thoracic Surgical Procedures;Tissues;Toxic effect;transcriptome sequencing;Treatment Efficacy;treatment response;treatment strategy;Trichrome stain;uptake;Ventricular Remodeling

PROJECT_TITLE: Maximizing Therapeutic Accumulation and Retention for Enhanced Cardiac Repair

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE To understand the brain in health and disease, identifying functional connections between neurons is essential. Optogenetics (to turn on neurons) and voltage biosensors (to read-out brain activity) are powerful tools for achieving this, but the current spectral compatibility between blue-absorbing voltage sensors and optogenetic reagents poses a limitation. This project proposes developing red voltage biosensors that operate on a different part of the spectrum, thereby overcoming this challenge and allowing experiments that provide new insights into how the brain works.

PI_NAMEs: REIMER, JACOB ;ST-PIERRE, FRANCOIS  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Red-shifted voltage indicators for two-photon all-optical physiology and multi-spectral imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (80)]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Oxidative stress, inflammation, and mitochondrial dysfunction contribute to endothelial dysfunction and atherosclerosis, which is a major cause of morbidity and mortality, predominantly occurring in arterial regions exposed to disturbed blood flow. Recently, excess copper (Cu) in mitochondria is shown to induce a new type of programmed cell death. We will demonstrate that endothelial Cu transporter, as a flow sensor, plays an important role in Cu levels, inflammation, mitochondrial dysfunction and programmed cell death in atherosclerotic lesions and potential therapeutic target for the treatment of vascular inflammatory disease.

PI_NAMEs: FUKAI, TOHRU  (contact);USHIO-FUKAI, MASUKO ;VARADARAJAN, SUDHAHAR

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acetylation;Address;Aorta;Apolipoprotein E;Apoptosis;Area;Arterial Fatty Streak;ATAC-seq;atherogenesis;Atherosclerosis;Binding;Biological Availability;Biosensor;Biotin;Blood flow;Blood Vessels;Carrier Proteins;Caveolae;Cell Death;Cells;Chelating Agents;chelation;Citric Acid Cycle;Copper;CRISPR/Cas technology;Cytosol;Data;Deacetylation;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Exposure to;Fluorescence;Fluorescence Microscopy;Fractionation;Functional disorder;Gene Expression;Gene Transfer;Genes;Grant;High Fat Diet;Human;in vivo;Inductively Coupled Plasma Mass Spectrometry;Inflammation;Inflammatory;innovation;insight;Knock-in;Label;Ligation;Measures;Mediating;Membrane Microdomains;Micronutrients;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Chaperones;Morbidity - disease rate;mortality;Mus;mutant;Mutant Strains Mice;Mutate;nanoparticle;novel;Nuclear;Nuclear Translocation;oxidation;Oxidation-Reduction;Oxidative Stress;Oxygen Consumption;Phase;Play;Proteins;response;Roentgen Rays;Role;sensor;single cell ATAC-seq;single-cell RNA sequencing;SIRT1 gene;Site;small hairpin RNA;Small Interfering RNA;Stains;Synchrotrons;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome sequencing;Transfection;uptake;vascular inflammation

PROJECT_TITLE: Cu uptake transporter as a disturbed flow sensor in vascular inflammatory disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


PHR: Narrative Aging is inexorably linked to the degeneration of tissues and cells, a process we believe is partially driven by the loss of normal DNA organization within cells. Leveraging state-of-the-art techniques, we are rigorously examining the intricate packaging of DNA within individual cells, with the goal of understanding the consequent implications of changes in this DNA organization on aging and associated disorders.

PI_NAMEs: JAIN, RAJAN  (contact);JOYCE, ERIC F.;LAKADAMYALI, MELIKE

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Address;Affect;age related;Age related pathologies;Aging;aging related;Alleles;Architecture;Biological Assay;Cell Aging;Cell Cycle;cell injury;Cells;cellular imaging;Chemicals;ChIP-seq;Chromatin;Chromatin Fiber;Chromatin Structure;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Disease;DNA;DNA Packaging;Electrons;Evaluation;Event;experimental study;Fibroblasts;Gene Expression;Gene Order;Genes;Genetic Induction;genetic regulatory protein;Genetic Transcription;Genome;Genomic approach;Genomics;Goals;Heterochromatin;Heterogeneity;high throughput screening;Homeostasis;human disease;Image;Imaging technology;Immune;Individual;Inflammation;Inflammatory;insight;interdisciplinary approach;interest;knock-down;Knowledge;Label;Lamin B1;Link;loss of function;Maintenance;Malignant Neoplasms;Masks;Mediating;Mediator;Modeling;Molecular;novel;Nuclear;Nuclear Lamina;Organizational Change;Peripheral;Phenotype;population based;Positioning Attribute;Process;Proliferating;Proteins;Resolution;RNA;RNA Polymerase II;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;single cell analysis;Small Interfering RNA;stem;superresolution imaging;superresolution microscopy;Techniques;Testing;Three-dimensional analysis;Time;tissue degeneration;Tissues;Transcriptional Regulation;Up-Regulation;Work

PROJECT_TITLE: Single-cell analysis of 3D genome organization in senescent cells

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative Skeletal muscle plays a critical role in glycemic control and metabolic homeostasis and is the predominant site of glucose disposal under insulin-stimulated conditions. Therefore, skeletal muscle function is a very important fundamental phenomenon in human health and disease. This project will use physiological and molecular approaches to identify new molecular pathways playing a role in muscle performance and metabolism.

PI_NAMEs: PURI, VISHWAJEET  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Aerobic;Agonist;Animals;Attenuated;Basic Science;Biology;Biopsy;blood glucose regulation;Characteristics;Chemicals;clinically relevant;Contracts;Cytoskeletal Proteins;Cytoskeleton;Data;design;Disease;Dynein ATPase;endurance exercise;exercise training;Fatty acid glycerol esters;Functional disorder;gain of function;GCG gene;genetic regulatory protein;GLP-I receptor;Glucose;glucose disposal;glucose uptake;glycemic control;Glycogen;Glycogen (Starch) Synthase;Glycogen Phosphorylase;Health;High Fat Diet;Homeostasis;Human;Impairment;indexing;innovation;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;interdisciplinary collaboration;Knockout Mice;Link;lipid metabolism;Lipids;loss of function;mechanical energy;Mediating;Metabolic;Metabolic Diseases;Metabolism;Microtubules;Modeling;Molecular;Motility;Motor;Motor Activity;mouse model;Movement;Mus;Muscle;Muscle Cells;Muscle function;muscle physiology;muscle strength;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organelles;Pathogenesis;Pathogenicity;Pathway interactions;Performance;Phenotype;Phosphorylation;Physical Function;Physiological;Play;Process;protein expression;Proteins;Radial;Receptor Signaling;recruit;reduced muscle strength;Regulation;Role;Signal Transduction;Site;Skeletal Muscle;skeletal muscle metabolism;Source;Testing;therapeutic target;Tissues;transcriptomics;Transgenes;Transgenic Mice;Translational Research;Vimentin;Work;young adult

PROJECT_TITLE: Identifying a novel player in skeletal muscle performance and metabolism

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases

PHR: NARRATIVE The novel mechanism of action of a class of complex molecules, cyclodextrins, was uncovered against a cytotoxic sphingolipid, galactosylsphingosine, or psychosine, which, at non-physiological higher levels, causes a devastating leukodystrophy. The characterization of a specific cyclodextrin and the synthesis of its new analogs to neutralize the cytotoxic effects of psychosine will lead to a potential therapy for an inborn lysosomal disorder caused by galactocerebrosidase deficiency, mostly known as Krabbe disease.

PI_NAMEs: MAEGAWA, GUSTAVO HENRIQUE BOFF (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;analog;Attention;Axon;Biological;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Cells;Cellular Assay;Central Nervous System;Chemicals;Child;Clinical Trials;Complex;Cyclodextrins;cytotoxic;cytotoxicity;Diffusion;Disease;Dose;efficacy evaluation;Encapsulated;Enhancers;Excipients;experimental study;fasting glucose;Fiber;Fibroblasts;galactosylceramidase;gene therapy;Globoid cell leukodystrophy;Glycosphingolipids;Goals;Hematopoietic;Hematopoietic Stem Cell Transplantation;high risk;Human;hydrophilicity;Hydrophobicity;hydroxypropyl-beta-cyclodextrin;improved;improved outcome;in vivo;infancy;innovation;Institution;intraperitoneal;Intravenous;Laboratories;Lead;leukodystrophy;life span;Light;lipophilicity;Live Birth;Low-Density Lipoproteins;Lysosomal Storage Diseases;Membrane Microdomains;Modeling;Modification;Molecular;Mouse Cell Line;mouse model;Mus;Myelin;Neonatal Screening;Nervous System;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurogenetics;Neurologic;Neurologic Symptoms;Niemann-Pick Diseases;novel;novel strategies;novel therapeutic intervention;Oligodendroglia;Oligosaccharides;Onset of illness;particle;Pathogenicity;Patients;Penetrance;Periodicity;Peripheral;Permeability;pharmacokinetics and pharmacodynamics;Phenotype;preservation;prevent;Property;Psychosine;Reporting;Resources;screening;screening program;Secondary to;Shapes;small molecule;small molecule therapeutics;Sphingolipids;standard of care;Structure;subcutaneous;success;Surface;Therapeutic;Therapeutic Agents;Validation;Water

PROJECT_TITLE: A Novel Molecular Neutralization Strategy for Cytotoxic Sphingolipid in a Neurogenetic Disorder

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Pediatric

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative: Mutations in taperin protein complex have been liked to hearing loss in humans, a major health problem that significantly affects the life quality of those affected. For this project we will investigate the functions of taperin protein complex in cochlear hair cells. We anticipate illustrating the physiological functions of taperin protein complex and the pathophysiological changes in hair cells that result from their mutations.

PI_NAMEs: FROLENKOV, GREGORY I;ZHAO, BO  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustic Trauma;Actins;Affect;Auditory;base;Binding;Biochemical;Biological Assay;Bundling;Catalytic Domain;Child;Cochlea;Complex;congenital deafness;congenital hearing loss;crosslink;Data;Dependence;Development;Elasticity;Electron Microscopy;experimental study;F-Actin;Fluorescence Microscopy;Genes;Genomics;Growth;Hair;Hair Cells;Health;hearing impairment;Human;In Vitro;in vivo;Inner Hair Cells;Knockout Mice;Link;Liquid substance;Macromolecular Complexes;mechanical properties;Mechanics;Microfilaments;microscopic imaging;Molecular;monomer;mouse model;Movement;Mus;mutant;Mutation;Names;normal hearing;overexpression;Phosphoric Monoester Hydrolases;Physiological;polymerization;Polymers;postnatal development;predictive modeling;Predisposition;prevent;protein complex;Protein Serine/Threonine Phosphatase;Proteins;Quality of life;Ramp;resilience;Rod;Rotation;Shapes;Side;sound;Speed;Stereocilium;Structure;Techniques;Testing;Variant;vibration;Video Recording

PROJECT_TITLE: Taperin-based macromolecular complex at the base of stereocilia

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public health relevance statement: This project will produce novel antibody conjugates that act as PD-L1 degraders for cancer immunotherapy. Additionally, it will establish a versatile platform to expedite the development of degraders targeting various cancer-associated protein targets, revolutionizing cancer treatment.

PI_NAMEs: TANG, WEIPING  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Adaptive Immune System;Address;Antibodies;antibody conjugate;antibody test;Asialoglycoprotein Receptor;Attention;Autophagocytosis;Binding;cancer cell;cancer immunotherapy;cancer therapy;cancer type;carbohydrate binding protein;Carbohydrate Chemistry;carbohydrate receptor;Cell membrane;Cell secretion;Cell surface;Cell Surface Receptors;cell type;Cells;Cellular Membrane;Chimera organism;Complex;Cysteine;Data;Degradation Pathway;design;Development;Endocytosis;Engineering;Environment;Evaluation;experience;Experimental Designs;experimental study;extracellular;Extracellular Protein;folate-binding protein;Folic Acid;Foundations;Head and Neck Cancer;Head and neck structure;Human;human disease;humanized mouse;IGF2R gene;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;inhibitor;innovation;interest;Investigation;Lectin;Ligand Binding;Ligands;Link;link protein;Liver;Lysine;Lysosomes;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Modality;Molecular Biology;mouse model;multicatalytic endopeptidase complex;Mus;Neck Cancer;Normal tissue morphology;novel;novel therapeutics;Organelles;overexpression;patient derived xenograft model;Play;Polysaccharides;programmed cell death ligand 1;Protac;protein degradation;Proteins;Proteome;proteostasis;public health relevance;receptor;receptor mediated endocytosis;recruit;Recycling;Reporting;Role;Route;Series;Standardization;Structure;System;Techniques;Testing;Therapeutic;therapeutically effective;Time;Tissues;Toxic effect;tumor;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Development of Novel Antibody Conjugates for Cancer Immunotherapy

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Public Health Relevance Statement Epstein-Barr virus (EBV) causes mononucleosis, triggers multiple sclerosis and causes multiple lymphomas. These studies will increase understanding of how EBV subverts metabolic pathways within infected lymphocytes present in blood and tonsils to enable the viral lifecycle, and may lead to novel therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adenoidal structure;Anabolism;Apoptosis;Automobile Driving;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Biochemical Pathway;Blood;burden of illness;Burkitt Lymphoma;Carbon;Carcinoma;Cell Compartmentation;cell growth;Cell membrane;Cell model;Cell Survival;cell transformation;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;craniofacial;CRISPR screen;Critical Pathways;Cues;Cysteine;Dependence;Enhancers;Epigenetic Process;epigenetic regulation;Epithelium;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Etiology;extracellular;Folic Acid;folic acid metabolism;Genes;genetic approach;Genome;genome-wide;Glutathione;Growth;Hodgkin Disease;Human;Human Herpesvirus 4;infected B cell;Infection;Infectious Agent;Infectious Mononucleosis;insight;Learning;Life Cycle Stages;Lipids;Lymphocyte;lymphoid structures;Lymphoid Tissue;Lymphoma;Lymphoproliferative Disorders;Malignant Neoplasms;Memory B-Lymphocyte;Messenger RNA;Metabolic Pathway;Metabolism;metabolomics;Methionine;Methionine Metabolism Pathway;Methylation;Modeling;Modification;Multiple Sclerosis;Nasopharynx Carcinoma;novel;novel therapeutic intervention;Nuclear Antigens;Nucleic Acids;nucleotide metabolism;Oncogenic;Oral cavity;Organoids;Oropharyngeal;Oxidation-Reduction;Pathway interactions;Peripheral;peripheral blood;Polyamines;post-transplant;programs;Proteomics;public health relevance;Reaction;Resistance;Role;Series;Serine;Signal Transduction;Structure;Structure of germinal center of lymph node;Tetrahydrofolates;Tissue Model;Tissues;Tonsil;transforming virus;uptake;Viral;Virus;Virus Latency

PROJECT_TITLE: Epstein-Barr Virus Driven Tonsillar Versus Peripheral B-cell One-Carbon Metabolic Network Remodeling

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: ROOTSTOWN

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

PHR: Project Narrative: Challenges with autogenous bone grafts have prompted significant need for effective and safe alternatives. We propose to develop and evaluate Gpnmb-therapeutics delivered via thermoresponsive hydrogels as an innovative therapeutic strategy for bone regeneration.

PI_NAMEs: OYEWUMI, MOSES O (contact);SAFADI, FAYEZ F

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adhesions;Amino Acids;Anabolic Agents;angiogenesis;Attention;Autologous;Binding;biomaterial compatibility;biomechanical test;Blood donor;bone;Bone Diseases;bone fracture repair;Bone Growth;Bone Injury;Bone Morphogenetic Proteins;Bone Regeneration;Bone Transplantation;Clinical;clinical application;comparative efficacy;Complementary DNA;controlled release;copolymer;cost;Coupled;Diffusion;Dose;Drug Delivery Systems;Effectiveness;efficacy evaluation;Ensure;ethylene glycol;Evaluation;expectation;extracellular;Future;Gel;Gene Expression;glycoprotein NMB;Glycoproteins;glycosylation;Goals;Hemorrhage;Heterotopic Ossification;Histology;Hydrogels;improved;In Situ;in vivo;Inflammation;Inflammatory;Injections;innovation;Integral Membrane Protein;Integrins;interest;Kinetics;Lateral;Liquid substance;manufacturing cost;Mediating;Melanoma;microCT;Modeling;Molecular Target;Molecular Weight;Morbidity - disease rate;Mus;mutant;Nonmetastatic;novel;novel therapeutic intervention;Operative Surgical Procedures;osteoactivin;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporotic;Peptides;Physiological;Postmenopause;Postoperative Period;Procedures;Property;protein B;Proteins;radiological imaging;Rattus;receptor;Recombinants;regenerative;regenerative approach;regenerative therapy;Regimen;response;Safety;side effect;Signal Transduction;Site;Spinal Fusion;success;System;Temperature;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;therapeutically effective;Time;Treatment outcome;treatment strategy;Work

PROJECT_TITLE: Delivery of GPNMB Therapeutics for Bone Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


PHR: Narrative Aged-and-obese Americans have a risk of developing type 2 diabetes of nearly 50% making them vulnerable to both direct negative consequences on lifespan and healthspan, as well as increasing risk for numerous age- related diseases including cardiovascular disease, cancer, and Alzheimer’s disease. New interventions to treat and prevent obesity and diabetes are thus urgently needed. This project seeks to determine if a diet low in specific dietary amino acids can reverse diet-induced obesity in a non-human primate and to understand the molecular mechanisms behind such actions.

PI_NAMEs: COLMAN, RICKI J (contact);LAMMING, DUDLEY WILLIAM

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adipose tissue;Adult;Affect;age effect;Age Factors;age group;age related;age-related disease;aged;Agreement;Alzheimer's Disease;American;Amino Acids;Blood;blood glucose regulation;Blood specimen;Body Composition;Body mass index;Branched-Chain Amino Acids;Caloric Restriction;Calories;Cardiovascular Diseases;Cell Aging;Consumption;Development;Diabetes Mellitus;Diet;Diet Modification;diet-induced obesity;dietary;Dietary Proteins;dietary restriction;disorder risk;Elderly;energy balance;epigenome;Essential Amino Acids;experimental study;extend lifespan;Fatty acid glycerol esters;Fatty Liver;feeding;Female;Future;Genetic;glycemic control;Health;Health Promotion;healthspan;healthy aging;High Fat Diet;High Prevalence;Histidine;Human;human old age (65+);improved;Individual;Inflammation;insight;Insulin Resistance;insulin sensitivity;Intake;Intervention;Isoleucine;life span;Link;Longevity;Macaca mulatta;Macronutrients Nutrition;male;Malignant Neoplasms;Metabolic;metabolomics;microbiome;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel;novel strategies;Obese Mice;Obesity;obesity prevention;obesity risk;obesity treatment;old mice;Overweight;Persons;Pharmacologic Substance;Phenotype;Population;preservation;Protein-Restricted Diet;Proteins;randomized, clinical trials;Rattus;response;restoration;Risk;Risk Factors;Rodent;Role;Sampling;senescence;sex;Skeletal Muscle;Sucrose;sugar;Surveys;Testing;Thinness;Tissue Sample;transcriptomics;Translations;Valine;western diet

PROJECT_TITLE: Translational analysis of a novel intervention to promote healthy aging.

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Recent work by our group established that ivosidenib is a potent wild-type IDH1 inhibitor with strong anti- pancreatic cancer effects under tumor-associated conditions, like low magnesium and glucose. In this proposal, we seek to optimize this treatment even further by nominating therapeutic partners that induce free radicals or shift metabolism towards oxidative phosphorylation, like a ketogenic diet or PARP inhibition. Further, we analyze patient samples to show that allosteric IDH1 inhibitors are indeed active against the wild-type enzyme, paving the way for future translational studies testing these combinatorial approaches in patients.

PI_NAMEs: BRODY, JONATHAN ;WINTER, JORDAN M (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Acetyl Coenzyme A;Affect;alpha ketoglutarate;anti-cancer research;Antioxidants;bioprinting;Carbon;Cations;Cell Line;Chemoresistance;chemotherapy;Citric Acid Cycle;Clinical;Clinical Trials;cofactor;combinatorial;Communication;Companions;comparison control;Data;Death Rate;Dependence;design;dietary;DNA Damage;DNA metabolism;DNA Repair;efficacy evaluation;efficacy testing;Enzymes;Epigenetic Process;Equilibrium;Exhibits;experience;FDA approved;Free Radicals;Future;future implementation;Generations;Genetic Transcription;Genetically Engineered Mouse;Glucose;Histone Acetylation;Histones;homologous recombination;homologous recombination deficiency;Hypermethylation;Immunologics;In Vitro;in vivo;in vivo Model;inhibitor;insight;Intervention;Isocitrate Dehydrogenase;Isocitrates;Isotope Labeling;ketogenic diet;Lysine;Magnesium;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;NADP;Nature;Neoadjuvant Therapy;Nutrient;Nutrient Depletion;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;PARP inhibition;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;preclinical study;Production;programs;Publications;Publishing;Reaction;Resected;Resources;Sampling;Serum;Solid Neoplasm;Source;standard of care;synergism;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;Tissues;translational study;treatment optimization;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Work

PROJECT_TITLE: Optimizing anti-wild-type IDH1 therapy in pancreatic cancer

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Indirect traumatic optic neuropathy (ITON) patients experience immediate optic nerve damage from the traumatic event followed by secondary neurodegeneration weeks later. We propose that the duration of the “latent” period prior to secondary neurodegeneration is determined by the ratio of healthy to dysfunctional mitochondria. We will test this in our mouse ITON model, quantifying mitochondria and mitochondrial quality control processes and testing the efficacy of mitochondria transplantation while all quantifying optic nerve structure and function.

PI_NAMEs: REX, TONIA S (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: antagonist;Astrocytes;Axon;axonal degeneration;Blindness;cell type;Connexins;cost;Data;Diagnosis;effective therapy;efficacy testing;Energy Metabolism;experience;Eye Injuries;family support;free radical oxygen;Freedom;Future;Goals;Head;Health;Healthcare;high resolution imaging;Histology;Injury;insight;Laboratories;Location;Measures;Mechanics;Medical center;Metabolic;Military Personnel;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;nerve damage;Nerve Degeneration;novel therapeutics;operation;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Patients;Penetration;preservation;prevent;Process;Quality Control;Resource Sharing;Resources;response;Retina;Retinal Ganglion Cells;Role;Secondary to;service member;SOD2 gene;Structure;Superoxides;Testing;Therapeutic;Transplantation;Trauma;Traumatic Brain Injury;traumatic event;United States;Vision;Visual evoked cortical potential;Vitamin E;Wallerian Degeneration;Work

PROJECT_TITLE: Mitochondria: controllers of trauma-induced secondary neurodegeneration onset

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: 2024 Cold Spring Harbor Laboratory Conference  GLIA IN HEALTH & DISEASE  PROJECT NARRATIVE The intricate functioning of the nervous system relies not only on the activity of neurons but also on the crucial contributions of glial cells. The “Glia in Health and Disease” conference, hosted biennially since 2006, remains the preeminent glial meeting. This meeting unites a diverse assembly of researchers investigating basic, fundamental biological mechanisms by which glia contribute to brain circuit development and function to translational neuroscientists who identify new glia-based targets for therapeutic intervention. Above all, the conference strategically engages leaders, seasoned investigators, and early-career scientists to interact and collectively share their latest discoveries on the intricate roles of glial cells in the nervous system.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Action Potentials;Address;Advanced Development;Aging;Alzheimer's Disease;Area;Automobile Driving;Axon;Behavior;Biochemistry;Biological;Biological Models;Biology;Blood flow;Blood Vessels;Brain;career;Cell Physiology;Cells;Cellular biology;Chronic;Cicatrix;cohort;Collaborations;Communities;Development;Disease;diversity and inclusion;empowerment;Ensure;Environment;Equity;Etiology;Faculty;forging;Fostering;Functional disorder;Future;Gene Mutation;Genes;Genetic;genetic manipulation;Goals;graduate student;Health;Human;human disease;human tissue;imaging approach;Imaging technology;Infection;Inflammation;Inflammatory;innovation;insight;interest;International;Invertebrates;Laboratories;laboratory facility;Lead;Length of Stay;Link;meetings;member;Metabolic;Methodology;Minority;Molecular;Molecular Biology;Multiple Sclerosis;Mutation;Natural regeneration;Nerve Regeneration;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neurodegenerative Disorders;neurodevelopment;Neuroglia;Neurons;Neurophysiology - biologic function;Neurotransmitters;new therapeutic target;operation;Oral;Participant;Pathologic;Pathology;Physiology;Play;Postdoctoral Fellow;posters;Reaction;repaired;Research;Research Personnel;response;Role;Schedule;Scientist;Seasons;Series;Signal Transduction;Stimulus;success;Supporting Cell of the Nervous System;symposium;Synapses;Synaptic plasticity;synergism;System;Talents;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;tissue repair;tool;Training and Education;Trauma;United States National Institutes of Health;unpublished works;Woman;Work

PROJECT_TITLE: CSHL 2024 Conference on Glia in Health & Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Effects of Indoor Air Pollution

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative This grant is written to request funding to support the 18th International Congress on Combustion By-Products and their Health Effects, also known as "PIC", to be held May 20- 22nd, 2024 in Durham, NC. This enduring and small conference provides a unique platform to share the latest science and exchange ideas across and among a diverse group of researchers from various fields, including academia, industry, and government officials. The goal of the Congress is to foster interactions and collaborations in a more narrowly focused research field compared to other large discipline-specific scientific conferences that have a larger breadth and parallel session formats.

PI_NAMEs: STAPLETON, HEATHER M (contact)

PROGRAM_OFFICER_NAME: TROTTIER, BRITTANY

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (R3)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Epilepsy;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: ESPOO

ORG_COUNTRY: FINLAND

ORG_FIPS: FI

ORG_NAME: AALTO UNIVERSITY

PHR: Narrative MEG, EEG, and invasive electrophysiological recordings can be used to understand and diagnose abnormalities underlying a wide range neurological and psychiatric illnesses including epilepsy, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders, and Alzheimer’s disease, as well as cognitive deficits such as delayed acquisition of language. However, widespread use of these methods especially in large populations has been problematic because of the lack of well-established analysis approaches, which map the sensor data into the brain space for detailed temporal, spatial, and connectivity analysis. This research will provide well-documented and tested novel analysis software to promote both basic neuroscience and clinical research applications of human electrophysiological recordings.

PI_NAMEs: HAMALAINEN, MATTI  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Aptitude;autism spectrum disorder;base;Basic Science;Brain;Brain imaging;Brain region;Clinical;Clinical Research;Code;Cognitive deficits;Communities;Compensation;Computer software;computerized data processing;Data;Data Analyses;data analysis pipeline;data format;Data Set;data standards;Databases;design;Development;Diagnosis;Disease;Documentation;Educational workshop;Electrocorticogram;Electrodes;Electroencephalography;Electromagnetics;Electrophysiology (science);Ensure;Epilepsy;flexibility;Frequencies;Functional Magnetic Resonance Imaging;Grant;hemodynamics;Human;human data;improved;Individual;innovation;Institution;Knowledge;Laboratories;Language Development;light weight;Machine Learning;magnetic field;Magnetoencephalography;Manufacturer;Maps;Measurement;Measures;Mental disorders;Methodology;Methods;millisecond;Modeling;Modernization;Neurologic;Neurosciences Research;Noise;novel;Obsessive-Compulsive Disorder;Online Systems;Optics;Population;Positioning Attribute;Process;Pump;Pythons;Reading;reconstruction;Reproducibility;Research;Research Personnel;Resolution;Sampling;Scalp structure;Schizophrenia;Science;sensor;Signal Transduction;Site;software development;Source;source localization;Statistical Data Interpretation;Stream;Structure;Surface;System;Techniques;Technology;Temperature;Testing;tool;Training;United States National Institutes of Health;verification and validation;Visualization;Work;Writing

PROJECT_TITLE: Scalable and Sensor-Agnostic Software for Distributed Processing and Visualization of Multi-Site MEG/EEG Datasets

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: Project Narrative This proposal requests support to facilitate the participation of early career scientists, especially women and individuals from underrepresented groups, in the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Cellular and Molecular Fungal Biology at the Holderness School, New Hampshire on June 16-21, 2024. The broad, time-honored goal of the GRC and GRS is to provide a vibrant forum for scientists from all disciplines, backgrounds and career stages, to discuss the latest fascinating discoveries in fungal biology and their application to societally and medically important problems.

PI_NAMEs: SELMECKI, ANNA M. (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Acceleration;anti-fungal agents;Area;Biology;Candidiasis;career;career development;Cells;Cessation of life;Chemicals;Communication;Communities;design;Development;Discipline;Disease;distraction;Effectiveness;Elderly;Environment;environmental adaptation;Evaluation;Evolution;extracellular;fascinate;fungus;Future;Genomics;Goals;graduate student;Healthcare;Hospitalization;Immunocompromised Host;Individual;Infant;Infection;insight;interdisciplinary collaboration;International;lectures;Medical;meetings;Microbe;microbial community;microorganism;Molecular;Morbidity - disease rate;Mycoses;New Hampshire;next generation;novel therapeutics;Oral;Organism;Participant;Pathogenesis;pathogenic fungus;patient population;Population;Postdoctoral Fellow;posters;recruit;Request for Proposals;Research;Research Personnel;response;Role;Running;Schools;Scientist;Students;Symbiosis;symposium;System;The science of Mycology;Therapeutic;Time;Underrepresented Populations;United States;Vesicle;Woman;Women's Group

PROJECT_TITLE: 2024 Cellular and Molecular Fungal Biology Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative  Eating disorders are an impairing and deadly psychiatric disorder with high rates of relapse. There is a need to improve our understanding of relapse to inform the design of more efficacious treatments and relapse prevention efforts; however, current research is limited by examining relapse as an outcome longitudinally (i.e., across 1 year) rather than a process that unfold through moment-to-moment choices engagement in ED behavior (i.e., lapses). The current study – informed by existing theory of relapse borrowed from substance use disorders15 – will capture the process at the momentary level, with the ultimate goal of identifying mechanisms of relapse that can be addressed through existing and new treatments.

PI_NAMEs: HUNT, ROWAN  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: adaptive intervention;Address;Adopted;Affect;Aftercare;Ambulatory Care;Behavior Disorders;Behavioral;Caring;Chronic;Cognitive;cognitive enhancement;Cognitive Therapy;comorbidity;contextual factors;cost;Data;Day Care;Dedications;design;Development;Dictionary;Disease;Disease remission;Distal;DOOR (deafness-onychodystrophy-osteodystrophy-retardation) syndrome;Eating Disorders;Ecological momentary assessment;effective therapy;efficacious treatment;emotion regulation;Equation;Event;Evidence based treatment;Expectancy;experience;follow-up;Frequencies;Goals;Grain;Grant;high risk;Impairment;improved;Individual;Inpatients;Intervention;intervention refinement;Interview;Lead;Life;Literature;long term recovery;longitudinal design;Measurement;Measures;medical complication;Mental Depression;Mental disorders;Methodology;Methods;Modeling;mortality;negative affect;Outcome;Participant;Patients;Phase;Prevention;preventive intervention;Process;Psychiatry;psychosocial;real time monitoring;Recovery;Recurrence;Relapse;relapse prediction;relapse prevention;relapse risk;Reporting;Research;Research Design;Research Personnel;Residential Treatment;response;Risk Factors;Role;Schizophrenia;severe mental illness;skills;social culture;Specific qualifier value;statistics;substance use;Substance Use Disorder;suicidal risk;Suicide attempt;Surveys;sustained recovery;Symptoms;Testing;Text;theories;Time;trait;Variant

PROJECT_TITLE: Real-Time Monitoring of Relapse in Eating Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Non-coding repetitive DNA sequences at the ends of eukaryotic chromosomes are called telomeres, and in many cancers they’re lengthened by the enzyme telomerase to achieve immortality. These telomeres are normally composed of deoxynucleotides, but they can also contain ribonucleotides, which are the most prevalent form of DNA damage. The overarching goal of this proposal is to understand the prevalence of telomeric ribonucleotides, how they are repaired, and how ribonucleotides alter telomeric integrity to promote chromosomal instability.

PI_NAMEs: FREUDENTHAL, BRET D (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Apoptosis;Architecture;base;Binding;Biochemical;Biological;Biological Assay;Biology;cancer risk;cancer type;carcinogenesis;Cell Aging;Cell division;Cell Survival;Cells;Characteristics;Chromosomal Instability;Chromosome abnormality;Chromosomes;Complex;Defect;Discrimination;Distal;DNA;DNA Damage;DNA Double Strand Break;DNA Sequence;DNA-Directed DNA Polymerase;Double Strand Break Repair;Elongation by Telomerase;Enzymes;Excision;Excision Repair;experimental study;G-Quartets;genetic information;Genome;Genome Stability;Genomic DNA;Genomic Instability;Genomics;Goals;Human;human disease;Hydrolysis;Length;Lesion;Link;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;mutant;Mutation;Pathway interactions;Play;Predisposition;premature;Prevalence;prevent;Proteomics;reconstitution;recruit;repaired;Repetitive Sequence;Resolution;Resolvase;response;Rest;Ribonucleases;Ribonucleoproteins;Ribonucleotides;Ribose;RNA-Directed DNA Polymerase;Role;senescence;single molecule;Source;Structure;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;Telomeric Repeat Binding Protein 1;Testing;Time;Untranslated RNA;Variant;Work

PROJECT_TITLE: Ribonucleotide Processing in Telomere Maintenance and Integrity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-S (02)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative The goal of the 2024 FASEB SRC on Biological Methylation is three-fold: (1) To bring together members with diverse expertise to bridge and foster collaborations and translational research in the fields of cancer, neurology, developmental biology, and small molecule inhibitors; (2) To provide an opportunity for scientists studying diverse aspects of the biochemistry, structure/function and disease relevance of SAM-dependent methylation to discuss recent research developments and to initiate collaborations; (3) To provide a supportive mentoring platform for trainees and junior investigators from diverse backgrounds, giving them opportunity to engage with those more established in their field.

PI_NAMEs: VAN RECHEM, CAPUCINE  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Academia;Area;Arginine;Asia;Australia;Biochemistry;Biological;Biology;Biotechnology;cancer therapy;career;career development;Caring;Cell Physiology;Chromatin;Clinical Research;Collaborations;Communities;COVID-19 pandemic;design;Development;Developmental Biology;Disease;DNA Damage;DNA Methylation;DNA Modification Methylases;educational atmosphere;Educational workshop;Ensure;Environment;Epigenetic Process;Equilibrium;Europe;Evaluation;Event;Family;Fostering;Funding;Gene Expression Regulation;Goals;graduate student;Grant;Health;Hematologic Neoplasms;Human;Human Development;human disease;Individual;Industry;Institution;interest;Italy;Life;Lysine;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Methionine;Methylation;Methyltransferase;Molecular;Neurology;non-histone protein;novel;Nucleic Acids;oncohistone;Participant;Persons;Portugal;Post-Translational Protein Processing;Postdoctoral Fellow;posters;programs;Protein Methylation;Protein Methyltransferases;Proteins;Reader;Regulation;Relaxation;Research;research and development;Research Personnel;response;RNA;RNA methylation;RNA Splicing;Role;Running;Science;Scientist;Senior Scientist;Series;Signal Transduction;small molecule inhibitor;Socialization;Solid Neoplasm;Structure;summer research;symposium;Therapeutic;therapeutic target;Time;Transcriptional Regulation;translational potential;Translational Research;Underrepresented Minority;Woman;Work;Writing

PROJECT_TITLE: Biological Methylation: Fundamental Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]