NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project narrative The chimeric antigen receptor T cells (CAR-Ts) is a novel therapeutic strategy that uses the patient’s own T cells to kill the tumor cells. This approach has changed the treatment landscape of B-cell malignancies however a significant percentage of patients with these diseases unfortunately relapse after CARTs infusion with limited effective treatment options available to them. Here, we propose the first in human clinical trial with in-house manufactured CAR-Ts targeting three proteins at the same time in patients with B-cell tumors with the goal of improving over the results of single antigen CAR-Ts.

PI_NAMEs: ALINARI, LAPO ;DE LIMA, MARCOS ;VASU, SUMITHIRA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute;Address;Adverse event;Antigen Targeting;Antigens;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Lymphomas;B-Cell Neoplasm;B-Cell NonHodgkins Lymphoma;B-Cell Prolymphocytic Leukemia;Blood Component Removal;Blood specimen;CAR antigen;CD19 gene;CD22 gene;CD28 gene;Cell Therapy;Cells;Cellular immunotherapy;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;Clinical;Clinical Trials;cohort;cost effective;cytokine;cytotoxicity;density;Devices;Disease;Disease remission;Dose;Down-Regulation;Economically Deprived Population;effective therapy;Enrollment;Evaluation;exhaustion;FDA approved;first-in-human;fitness;Flow Cytometry;Funding;Genetic Transcription;Goals;Good Manufacturing Process;Harvest;high dimensionality;human study;Immune;Immunophenotyping;Impairment;improved;In Vitro;in vivo;Incidence;Infusion procedures;innovation;insight;Laboratories;Lead;Logistics;loss of function;Lymphoblastic Leukemia;Lymphoma;Malignant lymphoid neoplasm;manufacture;manufacturing process;Mediating;Memory;Methodology;Methods;Modeling;Mononuclear;MS4A1 gene;neoplastic cell;next generation;novel;novel strategies;novel therapeutic intervention;Ohio;OX40;participant enrollment;patient subsets;Patients;Pattern;peripheral blood;Phase;phase 1 study;phase 2 study;phase I trial;Phenotype;point of care;pre-clinical;Pre-Clinical Model;pressure;prevent;primary endpoint;Proliferating;Proteins;Recommendation;Refractory;Relapse;relapse risk;Resistance;response;Risk Reduction;Safety;safety and feasibility;secondary endpoint;Severities;Specificity;stem;success;T memory cell;T-Lymphocyte;Testing;Time;Translating;Universities;Veins;Wait Time;Work

PROJECT_TITLE: Trispecific CAR-T cells targeting CD19, CD20 and CD22 to treat B-cell malignancies


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Survivors of childhood cancer require life-long healthcare to improve quality of life and health outcomes; yet, there are crucial gaps in our understanding of the modifiable factors that create and perpetuate disparities in healthcare among childhood cancer survivors in the Medicaid system. This study will use qualitative and survey research methods to systematically assess survivor experience of care in the Medicaid system and determine sources of disparities affecting care experience among adult survivors of childhood cancer. This study will inform future policies and interventions concerning the modifiable factors that can improve equity in healthcare for adult Medicaid beneficiaries with a history of childhood cancer.

PI_NAMEs: JI, XU  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Affordable Care Act;Age;Automobile Driving;Award;beneficiary;Cancer Center;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;care coordination;care delivery;care providers;career;Caring;Censuses;Characteristics;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Chronic;Chronic Disease;clinical care;Clinical Data;cohort;Communities;Cost Sharing;COVID-19 pandemic;Cross-Sectional Studies;Data;design;Detection;Discrimination;Disease;Disparity;Drops;Early treatment;Enrollment;Ensure;Equity;ethnic minority;Ethnic Origin;experience;Face;Financial Hardship;follow-up;Foundations;Future;Goals;hands-on learning;Health;health care disparity;health care quality;health disparity;health literacy;Healthcare;high risk;Impaired cognition;implementation science;Improve Access;improved;Individual;Institution;Insurance;Insurance Coverage;International;Intervention;Interview;Knowledge;Late Effects;Lead;Leadership;learning strategy;Link;Low income;low socioeconomic status;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurable;Measures;Medicaid;medical specialties;Mentorship;Methods;minority health;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Outcome;Participant;Patient Care;Patients;Pediatric Oncology;Policies;Population;post-pandemic;pre-pandemic;programs;public health insurance;Qualitative Methods;Quality of Care;Quality of life;Race;racial health disparity;racial minority;Rare Diseases;Recording of previous events;recruit;Reduce health disparities;Research;Research Methodology;Research Personnel;Research Priority;Role;rural disparities;rural dwellers;rurality;satisfaction;Scientist;Services;sex;sex disparity;skills;Societies;sociodemographic group;Socioeconomic Status;socioeconomics;Source;Structure;Survey Methodology;Surveys;Survivors;System;tool;Training;Underserved Population;United States;urban disparity;Validation;voltage;Work

PROJECT_TITLE: Disparities in Quality Healthcare Among Childhood Cancer Survivors: Role of Medicaid


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research evaluates immunogenicity of the dengue virus vaccine vaccine CYD-TDV in subjects with pre-existing dengue virus serotype 1 immunity. This knowledge is critical to understanding immune determinants of vaccine efficacy and is critical evaluation and improvement of this vaccine intended to control this globally important disease. The results of this project are highly and directly relevant to the NIH's mission fostering innovative research strategies to reduce the burden of illness and disease.

PI_NAMEs: MESSER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immune response;Address;aged;Antibodies;Antibody Response;Antibody Specificity;Antibody titer measurement;Area;Attenuated;burden of illness;CD8-Positive T-Lymphocytes;Cells;Collaborations;Complex;Country;cross reactivity;cytokine;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Disease;Disease Outbreaks;Dose;Evaluation;Exposure to;Flavivirus;Fostering;Founder Generation;Frequencies;Future;Genes;Genome;Health Sciences;Hospitalization;Immune;Immune response;Immunity;immunogenic;immunogenicity;improved;Individual;Inflammatory;inflammatory marker;Innate Immune Response;innovation;Investigation;Knowledge;Laboratories;Leukocytes;Membrane;Memory B-Lymphocyte;Mission;monocyte;mosquito-borne;multidisciplinary;Natural Killer Cells;neutralizing antibody;Neutrophil Activation;novel strategies;Pathway interactions;Phase;Play;Population;preclinical study;prospective;Public Health;Puerto Rican;Puerto Rico;randomized placebo controlled trial;Research;response;Risk;Role;Serotyping;Serum;severe dengue;Shapes;Specificity;Study of serum;T-Cell Activation;Testing;tool;United States National Institutes of Health;Universities;Vaccinated;Vaccination;vaccine development;vaccine efficacy;Vaccinee;Vaccines;Viral Load result;Viremia;Virus;Yellow Fever;Yellow Fever Vaccine

PROJECT_TITLE: Immunogenicity of the dengue vaccine CYD-TDV in a dengue virus serotype 1 immune population

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Estrogen;Neurosciences;Nutrition;Obesity;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Males and females differ with respect to complement-mediated innate immunity and susceptibility to obesity- induced pathophysiology in multiple tissues, including the brain. These experiments will determine whether sexually dimorphic regulation of complement underlies differential vulnerability to neuroinflammation in mice with dietary obesity. We will use state-of-the-art methodology, including machine learning-based reconstruction of glia in cleared brains, to generate a comprehensive topographical map of neuroimmune responses to chronic overnutrition and elucidate the role of complement in these effects.

PI_NAMEs: STRANAHAN, ALEXIS M. (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Abbreviations;Address;Adult;Adult women;Anatomy;arm;Astrocytes;Attenuated;Autologous;behavior test;Behavioral;Brain;brain cell;brain parenchyma;Brain region;Bystander Effect;Cell Death;cell type;Cells;Chimeric Proteins;Chronic;Clinical Research;Cognitive deficits;Complement;Complement 3b;Complement 3d Receptors;Complement Activation;Complement Inactivators;Complement Receptor;Data;Dementia;Detection;Development;Diet;dietary;dimorphism;Discrimination;Electrophysiology (science);Estrus;Exhibits;Experimental Models;experimental study;Female;Flow Cytometry;Functional disorder;functional outcomes;Gene Expression;gene induction;glial activation;Harvest;Heterogeneity;High Fat Diet;high throughput analysis;Hippocampus;Home;Homeostasis;Hydrogels;Impaired cognition;Implant;Inflammation;Inflammatory;inhibitor;insight;knock-down;Knowledge;Lectin;Link;Machine Learning;male;Maps;Measures;Mediating;Metabolic;Methodology;Microfluidics;Microglia;Modeling;Morphology;Mus;Natural Immunity;Nervous System;Neuroglia;Neuroimmune;neuroinflammation;Neuronal Plasticity;Neurons;neuropathology;Obesity;obesogenic;Overnutrition;Pathogenesis;Pathology;Pathway interactions;Pattern;Peripheral;Pilot Projects;Population;Predisposition;prevent;Process;promoter;Recombinant Fusion Proteins;reconstruction;recruit;Regulation;Research;Resistance;response;Role;Sex Differences;sexual dimorphism;sexual role;Signal Transduction;Site;Specificity;Synapses;synaptic function;System;Tamoxifen;Testing;Tissues;Transgenes;Transgenic Mice;Up-Regulation;Women's Group;Work;Y protein

PROJECT_TITLE: Cell type-specific complement activation and glial reactivity in male and female mice with dietary obesity

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Epigenetic alteration is one hallmark for aging and age-related diseases, which are the leading causes of morbidity and mortality in the general public health. Three-dimensional (3D) enhancer regulation is not understood in aging and its interplay with inflammation is unclear. The proposed research will unveil the cell type-specific mechanisms of 3D enhancer regulation in different contexts of aging and age-related disease and shed light on potential epigenetic therapeutic targets.

PI_NAMEs: WANG, LU  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;age related;age-related disease;Aging;aging related;career;career development;cell age;cell type;Cells;Chromatin;Chronic;cofactor;connectome;Data;Diet;Disease;Enhancers;Ensure;Epigenetic Process;experience;Fatty acid glycerol esters;fatty liver disease;Fibroblasts;Foundations;functional decline;Future;Gene Expression;General Population;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;hallmarks of aging;healthy aging;Hepatocyte;Histone Acetylation;Human;Immune;Immunology;in vivo;Inflammation;Inflammatory;insight;Intervention;Knockout Mice;Link;Liver;Malignant Neoplasms;Maps;Mediating;Mentors;Metabolic;Metabolic Diseases;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;non-alcoholic;normal aging;novel;Oncogenic;Pathway interactions;Phase;Phenotype;Predisposition;Probability;programs;Proliferating;promoter;Public Health;Regulation;Regulatory Pathway;Rejuvenation;Research;response;Secure;senescence;senescent cell;Signal Transduction;Source;Specificity;Stimulator of Interferon Genes;Stress;Structural Protein;Testing;therapeutic target;Time;Tissues;Training;transcription factor

PROJECT_TITLE: Mechanisms of enhancer regulation in aging and age-related diseases

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Kidney Disease;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative: This competitive renewal application aims to define genetic mechanisms underlying IgA nephropathy and IgA vasculitis with nephritis, two related conditions that contribute to kidney failure worldwide. The proposal integrates multi-phenotype genome-wide association studies, epigenetic analysis of IgA+ cells, focused gene perturbation experiments in IgA+ cells, studies of human knockouts in the Pakistan Genomic Resource, and clinical studies in prospective cohorts. These studies aim to identify new targets for therapeutic interventions.

PI_NAMEs: KIRYLUK, KRZYSZTOF  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Affect;Antibodies;Antigen-Antibody Complex;B-Cell Antigen Receptor;biobank;Biological;Biological Markers;Blood;Blood Vessels;Callback;Candidate Disease Gene;candidate validation;causal variant;Cell secretion;Cells;Characteristics;Childhood;Chromosome Mapping;Circulation;Clinical;Clinical Research;clinical translation;cohort;Complex;consanguineous family;CRISPR/Cas technology;cytokine;Defect;Deposition;Development;Disease;Disease Progression;Disease susceptibility;disorder risk;Drug Targeting;endophenotype;Epigenetic Process;Exhibits;experimental study;Family;Funding;gain of function;Galactose;gastrointestinal;Gene Targeting;Generations;Genes;Genetic;genetic analysis;genetic architecture;Genetic Predisposition to Disease;Genetic Risk;genetic signature;genetic variant;genome resource;genome wide association study;genome-wide;genomic locus;Genomics;Glomerulonephritis;glycosylation;Goals;Grant;Health;Henoch-Schoenlein Purpura;Heritability;Heterozygote;high risk;Histopathology;Human;IGA Glomerulonephritis;IgA receptor;IgA1;Immune;Immune system;Immunoglobulin A;Immunoglobulins;Immunologics;Immunophenotyping;In Vitro;Individual;Injury to Kidney;insight;interest;Intestinal Mucosa;Joints;Kidney;Kidney Diseases;Kidney Failure;Knock-out;Ligands;loss of function;Maps;Mediating;Mendelian randomization;Meta-Analysis;Modeling;Mucous Membrane;Multicenter Studies;multiple omics;Myeloid Cells;Nephritis;Network-based;new therapeutic target;novel;Outcome;Pakistan;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;phenome;Phenotype;population based;prospective;Prospective cohort;Proteome;receptor;Regulatory Element;Resolution;response;Risk;risk variant;Role;Serum;Severities;Signal Transduction;single nucleus RNA-sequencing;Skin;Small Interfering RNA;Study of serum;Susceptibility Gene;System;Therapeutic Intervention;Time;trait;Validation;Variant;vascular inflammation;vascular injury

PROJECT_TITLE: Genetics of IgA nephropathy by integrative network-based association studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Osseointegrated dental implants have become a clinical standard for replacing missing teeth and are now an important routine component of dental practice. Due to its popularity, the presence of implant complications is rising, making it challenging to sustain implants in the long term. We propose to develop an innovative anti- bacterial adhesion and anti-inflammatory dental implant system that prevents implant failure while promoting long-term stability.

PI_NAMEs: HWANG, GEELSU  (contact);KIM, ALBERT ;SCHAER, THOMAS P

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Adhesives;Affect;Age;alveolar bone;Alveolar Bone Loss;Anti-Bacterial Agents;Anti-Inflammatory Agents;anti-microbial peptide;antimicrobial;Apoptosis;Bacterial Adhesion;Bicuspid;Biomechanics;Bite Force;Bone Resorption;Cell Communication;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Clinical;clinical examination;clinical practice;Coculture Techniques;Crowns;cytokine;Data;Dental crowns;Dental General Practice;Dental Implants;Dental Plaque;Development;Disease;disorder prevention;dosage;Dose;efficacy evaluation;efficacy testing;electrical potential;Engineering;Environment;Epithelial Cells;experimental study;Failure;Fibroblasts;Future;Generations;Gingiva;Goals;Head;healing;Human;human tissue;Implant;implantable device;In Situ;in vivo evaluation;in vivo Model;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Invaded;Joint Prosthesis;keratinocyte;Ligature;Light;light emission;Limb Prosthesis;Longevity;Mastication;Measures;Mechanics;Mediating;Microbe;microbial;Microbial Biofilms;microCT;Modeling;Molar tooth;Motion;Mucositis;multimodality;next generation;novel;Operative Surgical Procedures;Oral;oral pathogen;Osseointegration;Outcome;particle;Pathogenesis;pathogenic microbe;Patients;peri-implantitis;Periodontitis;Phenotype;photobiomodulation;Phototherapy;Populations at Risk;porcine model;preservation;prevent;Production;Property;Protocols documentation;Recording of previous events;Resistance;response;restoration;Risk Reduction;Rupture;Sampling;seal;Secure;self assembly;Self Assessment;senescence;Signal Pathway;Silk;Smoking;soft tissue;Stimulus;Structure;Surface;System;Systemic disease;Testing;tissue culture;Tissues;Titanium;Tooth structure;Toothbrushing;United States;X-Ray Computed Tomography

PROJECT_TITLE: Translational Multimodal Strategy for Peri-Implant Disease Prevention

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The field of aging research is rapidly expanding and is likely to continue to produce results that will have enormous impacts on individuals and society. The Stanford Training Program in Aging Research (TPAR) is designed not only to train postdoctoral fellows to have highly successful careers in aging research, but also to form the next generation of leaders in this field in academia, medicine, industry, and related professions.

PI_NAMEs: GITLER, AARON D.;PERIYAKOIL, VYJEYANTHI S;WYSS-CORAY, TONY  (contact)

PROJECT_TERMS: Aging;Research;Training Programs


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: NARRATIVE The accumulation of dental plaque into stable, long-range biofilms at the gingival margin is implicated in reversible gingivitis, which may progress to chronic periodontitis. However, the specific cells and molecular interactions that govern dental plaque structure are not well known. The knowledge gained from the research proposed here will comprise a holistic understanding of oral community assembly processes and physical structure across spatial scales and may identify new paradigms for intervening in the progression of dental plaque-mediated diseases.

PI_NAMEs: VALM, ALEX M (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Activities of Daily Living;Address;Apical;Bacterial Adhesins;Binding;Biochemical;Cell Communication;Cells;Coculture Techniques;Communities;Complement;Corynebacterium;Dental Plaque;Development;Disease;Ecosystem;Escherichia coli;Event;Filament;Fusobacterium;Fusobacterium nucleatum;Genes;Genetic;Gingiva;Gingivitis;Growth;Health Promotion;Health Transition;healthy volunteer;Heterogeneity;Image;imaging study;imaging system;In Vitro;Inflammatory;Knowledge;Leptotrichia;Location;Maps;Mediating;Membrane Proteins;Messenger RNA;metagenomic sequencing;Metagenomics;Microbe;Microbial Biofilms;microbiome;Modeling;Molecular;mutant;neutralizing antibody;novel;Oral;oral biofilm;Oral cavity;oral microbial community;Organ;Organism;Oxygen;Pathogenicity;Pathway interactions;Pattern;Periodontal Diseases;Periodontitis;Phase;Phenotype;Play;polymicrobial biofilm;prevent;Process;Property;Proteins;Publishing;receptor;Research;Resolution;Role;Spatial Distribution;Structure;Structure-Activity Relationship;success;Surface;synthetic biology;Taxonomy;Testing;theories;Tissues;tooth surface;Transcript;transcriptome sequencing;Work

PROJECT_TITLE: Oral microbial community structure and assembly: from molecule to microbiome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative: Given the prospect to develop effective AD therapies via current therapeutic strategies seems limited at this point, in this application we propose to develop a new class of AD drugs that target previously unrecognized pathways in AD drug development. We expect to identify a lead AD drug to stop or slow down the progression of AD in a manner independent of Aβ or tau aggregation that needs to be further investigated in clinical trials. Successful completion of our study will have an important positive impact because currently available drugs only offer temporary relief from the symptoms of AD.

PI_NAMEs: KIM, KYUNG BO  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: ABCB1 gene;abeta accumulation;Affect;Alkenes;Alzheimer's Disease;Alzheimer's disease model;analog;APP-PS1;Astrocytes;Biological;Brain;brain tissue;C-terminal;chemical stability;Circulation;Clinic;Clinical;clinical candidate;clinical development;Clinical Trials;Cognitive deficits;comparative;Data;Development;Dose;drug candidate;drug development;drug discovery;drug disposition;Drug Efflux;Drug or chemical Tissue Distribution;Drug Targeting;Ensure;Epoxide hydrolase;Event;Excretory function;expectation;Failure;Family;Family member;Human;Hydrolysis;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Inflammasome;inhibitor;Interleukin-1 alpha;Lead;lead candidate;Macrocyclic Compounds;Mediating;Metabolic;Metabolism;mouse model;multicatalytic endopeptidase complex;Mus;neuronal survival;new therapeutic target;novel;novel drug class;Organ;Pathway interactions;Patients;Peptide Hydrolases;Peptides;Permeability;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;preclinical study;Property;Reaction;reduce symptoms;Reporting;Safety;Specificity;success;tau aggregation;tau Proteins;Therapeutic;Time;Toxic effect;Transgenic Mice;Variant

PROJECT_TITLE: Immunoproteasome inhibitors for the treatment of Alzheimers disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


PHR: NARRATIVE Periodontal disease is affects an estimated 40% of US adults and remains a significant challenge to diagnose at early stages. The work proposed here will foster a better understanding of the structural features of plaque biofilms that are involved in the early initiation of periodontal disease and may foster the development of new strategies to monitor and treat and prevent these diseases.

PROJECT_TERMS: Address;Adult;Affect;Architecture;Bacteria;Biochemical;canine model;Canis familiaris;Cells;Chronic;Clinical Markers;Coculture Techniques;Communities;comparative;Data;dental biofilm;Dental Plaque;design;Development;Diagnosis;differential expression;Disease;Disease Progression;dysbiosis;Epithelium;Fostering;Gene Expression;Genes;Gingiva;Gingivitis;Health;Health Transition;healthy volunteer;holistic approach;Human;human model;Image;Image Analysis;Immune;Immune response;Immune system;Inflammation;Inflammatory;Inflammatory Response;Knowledge;Linear Regressions;Location;Machine Learning;Maps;Mediating;Messenger RNA;metagenomic sequencing;Metagenomics;metatranscriptomics;Microbe;microbial;Microbial Biofilms;microbial community;Monitor;novel;Organism;pathobiont;pathogen;Pathogenicity;Patients;Periodontal Diseases;Periodontitis;Play;polymicrobial biofilm;Porphyromonas gingivalis;prevent;Process;quantitative imaging;Research;Role;scaffold;Spatial Distribution;Structure;Structure-Activity Relationship;subgingival biofilm;subgingival microbiome;success;Sum;Surveys;Taxon;Taxonomy;Testing;Time;Tissue-Specific Gene Expression;Tooth structure;tooth surface;transcriptome sequencing;whole genome;wisdom tooth;Work

PROJECT_TITLE: Biofilm Spatial Structure in the Transition from Health to Periodontal Disease


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Hematology;Infectious Diseases

ORG_CITY: GERMANTOWN

ORG_NAME: PRIMETIME LIFE SCIENCES, LLC

ORG_STATE: MD

PHR: Project Narrative Giardia lamblia, a waterborne human parasite that inflicts 1.2 million people annually worldwide, is classified as a category B bioterrorism organism and also is included in Neglected Diseases Initiative by World Health Organization. The goal of this project is to develop PTLS-209, a potent MetAP2 inhibitor with very low oral bioavailability, as a safe and effective antigiardiasis drug, particularly resistant strains.

PI_NAMEs: PADIA, JANAK K (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adopted;Adverse effects;analog;Animals;benzimidazole;biodefense;Biological;Biological Assay;Biological Availability;Bioterrorism;Canis familiaris;Carbamates;Categories;Cessation of life;Chemicals;Child;chronic infection;Classification;clinical predictors;Clinical Research;Clinical Trials;Coagulation Process;combat;contaminated water;Cyst;Developing Countries;Development;Diarrhea;Disease;Dose;Drug Exposure;Drug Kinetics;Drug resistance;Drug Targeting;Drug usage;economic impact;Enzymes;Esters;Evaluation;Event;experimental study;Fasting;foodborne;Formulation;fumagillin;genotoxicity;Giardia;Giardia lamblia;Giardiasis;global health;Goals;Growth;Hematology;Hemostatic function;Human;Humidity;Impairment;improved;In Vitro;in vivo;Incidence;inhibitor;Intestines;Laboratories;Lead;lead optimization;Libraries;Liquid substance;Malnutrition;manufacture;Metabolism;Methods;Metronidazole;Microsporidiosis;Molecular Target;mouse model;Mus;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;neglect;Nitroimidazoles;novel therapeutics;Oral;Oral Administration;Organism;Outcome;Parasites;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Plasma;preclinical development;preclinical study;Prevalence;Process;process optimization;Production;Recovery;Research Personnel;Resistance;Resistance development;resistance mechanism;resistant strain;Resources;Risk;Risk Assessment;risk mitigation;Rodent;Safety;Sampling;scale up;screening;sex;side effect;Small Business Innovation Research Grant;socioeconomics;Specificity;stability testing;standard care;Stomach;subcutaneous;Temperature;Testing;therapy development;Toxic effect;Toxicokinetics;Treatment Failure;United States National Institutes of Health;Water;waterborne;World Health Organization

PROJECT_TITLE: Development of PTLS-209 for treatment for giardiasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(14)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE People with long-term liver diseases are at a high risk for developing hepatocellular carcinoma, a difficult to treat and often deadly tumor. This project will examine the role of a protein in the membrane surrounding the cell nucleus whose altered expression drives the development of HCC in the setting of long-term liver disease.

PI_NAMEs: SHIN, JI-YEON  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Appearance;Automobile Driving;Binding;cancer cell;Carcinogens;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Proliferation;Cells;Chromatin;Chromatin Remodeling Factor;chronic liver disease;Cirrhosis;Data;Development;Differentiated Gene;Disease;env Gene Products;epigenetic regulation;fetal;Gene Expression;Genes;genomic locus;Growth;Hepatic;Hepatocarcinogenesis;Hepatocyte;hepatoma cell;high risk;Homeostasis;Homologous Gene;Human;human induced pluripotent stem cells;imprint;in vivo;Injections;insight;Iodothyronine Deiodinase;Lead;Ligands;Link;lipid metabolism;Lipids;liver cancer model;Liver diseases;Liver neoplasms;Malignant Neoplasms;Membrane;Modeling;mouse model;Mus;Mutation;Neoplasms;neoplastic cell;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;notch protein;novel;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Oncogenes;Oncogenic;Patients;Persons;Plasmids;polypeptide;Predisposition;prevent;Primary carcinoma of the liver cells;Process;Prognosis;programs;Proliferating;Protein Isoforms;Proteins;Reporter;Research;Risk;Role;selective expression;simple steatosis;stem cell genes;stem cells;Testing;tumor;tumor initiation;tumor progression;tumorigenesis;α-Fetoproteins

PROJECT_TITLE: Nuclear envelope and predisposition to hepatic neoplasia

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE- OVERALL While Delaware has high quality healthcare compared to other states, Delaware still has significant inequities in health and healthcare for non-White Delawareans; further, Delaware lags behind other states in a number of areas, including drug deaths, obesity, high preventable hospitalization rates, multiple chronic conditions and cancer. As such, the overarching goal for the continuation of the ACCEL CTR Program is to create a unified Delaware Clinical and Translational Research Community (inclusive of investigators and community members) that breaks down existing barriers, capitalizes on the unique strengths of its partners to establish infrastructure and accelerates the creation of equitable solutions that improve the health of all Delawareans and all Americans.

PI_NAMEs: HICKS, GREGORY E (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acceleration;Adult;African American;Agreement;American;Area;Asian;Award;Biometry;Black race;Budgets;Caucasians;Cessation of life;Child Health;Childhood;Clinical;clinical infrastructure;Clinical Research;Communities;community engagement;Community Outreach;Delaware;design;Development;Epidemiology;Equity;Ethnic Origin;Evaluation;Funding;Goals;Grant;Growth;Health;health care quality;health equity;health inequalities;Health Promotion;Healthcare;Healthcare Systems;Hispanic;hospitalization rates;Hospitals;improved;Infrastructure;innovation;Institution;Intention;Investments;Learning;Letters;Malignant Neoplasms;member;Mission;Modeling;Modification;multiple chronic conditions;Native Americans;Obesity;Outreach Research;Pharmaceutical Preparations;Pilot Projects;Population;population health;Population Heterogeneity;Population Research;programs;racial diversity;Recommendation;recruit;Research Design;Research Personnel;Rural;Scientist;Societies;Structure;System;Time;Training;Translational Research;translational research program;translational scientist;Universities;Work;Writing

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative This project will assess the impact of a novel breastfeeding support intervention (“telelactation”), delivered via video calls on personal devices including mobile phones and tablets. The goal of this intervention is to increase access to International Board Certified Lactation Consultants to improve, and reduce disparities in, breastfeeding rates. By implementing a “siteless” randomized controlled trial that recruits participants through a popular pregnancy tracker mobile phone application, this study will efficiently recruit a national sample of 2400 diverse women to 1) provide evidence on the effectiveness of a widely available, yet understudied, service and 2) leverage technology to promote one of the most widely recommended health behaviors to improve children’s health and to reduce disparities in key maternal and child health outcomes.

PI_NAMEs: USCHER-PINES, LORI  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Age;Age Months;American;Black race;black women;Board Certification;Breast Feeding;Case Study;Cellular Phone;Child Health;Communities;compare effectiveness;Consult;cost;Data;Dedications;design;Devices;Diet;Disparity;disparity reduction;Effectiveness;effectiveness evaluation;eHealth;ethnic minority;Ethnic Minority Women;Ethnic Origin;Ethnic Population;experience;Exposure to;Future;Goals;Health;Health behavior;health disparity;Home;Human Milk;improved;Infant;innovation;International;Intervention;Interview;Lactation;Lactation consultant;Latina;Link;Maternal and Child Health;Mediating;Mediator;Medical;Methods;Minority;minority communities;Minority Participation;Minority Women;Modeling;Mothers;novel;Observational Study;Office Visits;Outcome;Patient Recruitments;Patients;pediatrician;Pennsylvania;Persons;Pilot Projects;Policies;poor health outcome;Positioning Attribute;Postpartum Period;Postpartum Women;preference;Pregnancy;Pregnant Women;Provider;Publishing;Race;racial minority;racial minority women;racial population;Randomized;randomized controlled design;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Resources;Risk;Rural;Rural Community;Sampling;satisfaction;Self Efficacy;Services;Surface;Surgeon;Surveys;Tablets;Technology;telelactation;Time;Training;Travel;treatment as usual;Underserved Population;urban area;video chat;Videoconferencing;virtual;Visit;White Women;Woman

PROJECT_TITLE: The Impact of Telelactation Services on Breastfeeding Outcomes among Minority Mothers: Siteless Tele-MILC Trial

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative Please refer to the overall section.

PROJECT_TERMS: Address;Administrative Efficiency;American;Award;Biometry;Black race;Businesses;Child Health;clinical infrastructure;Clinical Research;Collaborations;Communication;community engagement;Community Outreach;Data;Decision Making;Delaware;Development;Ensure;Epidemiology;Evaluation;expectation;Extramural Activities;flexibility;Funding;Goals;Growth;Health;health equity;health inequalities;health organization;Healthcare;Healthcare Systems;implementation facilitation;improved;Institution;Medical;Mission;Occupational activity of managing finances;operation;Pediatric Hospitals;Performance;Pilot Projects;Productivity;programs;Regulation;Research Design;Research Infrastructure;Research Personnel;Resources;sound;South Carolina;Structure;success;Translational Research;translational research program;Trust;Universities;Work

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program (Admin Core)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative  Please refer to the overall section.

PI_NAMEs: WENNER, MEGAN M (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Area;Award;career;career development;Clinical;clinical infrastructure;Clinical Research;Collaborations;Communities;community collaboration;community engaged research;community engagement;Community Outreach;Complex;Computer software;cultural values;Data;Delaware;Development;Discipline;Ensure;equipment acquisition;Evaluation;Event;experience;Extramural Activities;Fostering;Funding;Funding Mechanisms;Grant;Health;health disparity;health equity;Health Priorities;Healthcare;Human Resources;Infrastructure;Institution;interdisciplinary collaboration;Medical;medically underserved;meetings;member;Mentors;Mission;Modeling;novel;outreach;Peer Review;Pilot Projects;Productivity;professor;programs;Qualifying;Recommendation;Research;Research Activity;Research Personnel;Research Project Grants;Scientist;Series;Services;sound;success;synergism;Testing;Training;translational barrier;translational pipeline;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program (Pilot Core)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

PHR: PROJECT NARRATIVE The dorsal anterior cingulate cortex, nucleus accumbens, and amygdala are regions of the human brain that are reciprocally connected in several major neural circuit loops. These brain regions serve as key nodes within the brain’s reward circuitry, and also play critical regulatory roles in mediating anxiety and fear-related behaviors. In this application, we will generate spatial transcriptomic maps in these human brain regions. This data will be used to better understand the molecular correlates of substance use and comorbid neuropsychiatric disorders.

PI_NAMEs: MARTINOWICH, KERI  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Address;Adult;Amygdaloid structure;Anatomy;Anterior;Anxiety;Architecture;Area;Autopsy;Behavior;Biological Process;Brain;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Chromium;cingulate cortex;Classification;Clinical;comorbidity;Data;Data Set;differential expression;Disease;Dorsal;Drug Addiction;Environmental Risk Factor;Exposure to;Female;Fluorescent in Situ Hybridization;Fright;Gene Expression;Gene Expression Profile;Genes;Genetic Risk;Genomics;Goals;Human;Individual;Link;Location;Major Depressive Disorder;male;Manuals;Maps;Measurement;Mediating;Mental disorders;Molecular;neural circuit;Neuroanatomy;Neurons;neuropsychiatric disorder;novel;Nucleus Accumbens;Pattern;Play;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Prevention;Process;Regional Anatomy;reward circuitry;Rewards;Rodent;Role;Sampling;sequencing platform;Signal Transduction;single molecule;single nucleus RNA-sequencing;spatial integration;Spottings;Stress;Structure;Substance abuse problem;substance use;Tissue-Specific Gene Expression;tool;transcriptome;transcriptome sequencing;transcriptomics;traumatic event

PROJECT_TITLE: Registration of spatial gene expression in key nodes of reward-related circuitry in the human brain


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety

PHR: PROJECT NARRATIVE Our research has public health significance because atrial fibrillation is the most common cardiac arrhythmia and expected to double in prevalence in the next decade as the population ages. “Real-world evidence” from electronic health record data displayed in personalized decision-aid visualizations can enable patients and providers to choose together the optimal treatments for symptom reduction. Our proposal addresses NINR's key areas of “Symptom Science: Promoting Personalized Health Strategies” and “Promoting Innovation: Technology to Improve Health” by leveraging innovative technologies to deliver personalized interventions that reduce symptom burden and improve quality of life for individuals with chronic conditions. !

PI_NAMEs: TURCHIOE, MEGHAN READING (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Ablation;Academic Medical Centers;Address;Affect;Age;Area;Arrhythmia;associated symptom;Atrial Fibrillation;Award;Benefits and Risks;biomedical informatics;Cardiac ablation;Cardiovascular system;career;Caring;Characteristics;Chronic;Clinical;clinical practice;common symptom;Communication;comorbidity;Competence;Complex;computer human interaction;Consultations;Data;Data Display;Data Reporting;Data Science;data visualization;Decision Aid;Devices;Dyspnea;electronic health data;Electronic Health Record;Electrophysiology (science);Enabling Factors;Ensure;experience;Faculty;Fatigue;Feasibility Studies;Funding;Goals;Grant;Health;health equity;Health Personnel;health related quality of life;Healthcare;Impaired health;Impairment;implementation science;improved;Individual;individual patient;innovation;innovative technologies;insight;instrument;International;Intervention;Interview;Investigation;Lead;Learning;Life Style;Machine Learning;machine learning method;Measures;member;Mentors;Methods;mHealth;minimally invasive;Mobile Health Application;Modality;Monitor;multidisciplinary;Natural Language Processing;novel strategies;Nursing Informatics;optimal treatments;Outcome;Palpitations;Patient Outcomes Assessments;Patients;Pattern;personalized decision;personalized intervention;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Predisposing Factor;Prevalence;Procedures;Process;programs;Protocols documentation;Provider;Public Health;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reading;reduce symptoms;Reinforcing Factor;Reporting;Research;Research Activity;Resources;Risk;Sampling;Scientist;shared decision making;Site;statistics;success;Symptom Burden;symptom management;symptom science;symptomatic improvement;Symptoms;Techniques;Technology;Training;Training Activity;treatment risk;user centered design;Validation;Visualization;Work

PROJECT_TITLE: Data-driven shared decision-making to reduce symptom burden in atrial fibrillation

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(76)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: AKINS, ROBERT E (contact)

PROJECT_TERMS: Address;Area;Award;base;Biomedical Research;Centers of Research Excellence;Clinical;clinical development;Clinical Research;Clinical Trials Network;Collaborations;community based research;community engagement;community partnership;Competence;Complex;Consultations;Delaware;design;Development;Discipline;Disparity;diversity and inclusion;Education;education resources;Educational Curriculum;Educational process of instructing;Environment;Equity;equity, diversity, and inclusion;experience;Extramural Activities;Faculty;Fostering;Foundations;Funding;Goals;Grant;Grant Review;Growth;health equity;improved;Individual;Inequity;Institution;interest;Intervention;K-Series Research Career Programs;Measures;meetings;member;Mentors;multidisciplinary;outreach;Pathway interactions;peer;peer coaching;peer networks;peer support;Process;Productivity;Program Development;programs;recruit;Research;research and development;Research Design;research faculty;Research Personnel;Research Proposals;research study;Research Training;Resources;satisfaction;Schools;Scientist;Secure;senior faculty;social determinants;Subgroup;success;Teacher Professional Development;tool;Training;Translational Research;translational scientist;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Workplace;Writing

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program (Professional Development Core)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: JURKOVITZ, CLAUDINE T (contact)

PROJECT_TERMS: Address;Ally;Area;Artificial Intelligence;Behavioral;Bioinformatics;biomedical informatics;Biometry;Biostatistical Methods;Biostatistics Core;Child Health;Clinical;Clinical Investigator;Clinical Research;Cloud Computing;Collaborations;Community Health;computer scientist;Data;Data Science;Databases;Delaware;design;Disease;Education;Electronic Health Record;Environment;Epidemiologist;Epidemiology;Equity;Fostering;Funding;Goals;Grant;Health;health disparity;health equity;health inequalities;Health Sciences;Health Services;Health system;Healthcare;Historically Black Colleges and Universities;improved;Individual;Infrastructure;innovation;insight;Institution;interest;Knowledge;Learning;lectures;Machine Learning;Medical;Methodology;Methods;minority health;Natural Language Processing;novel;Phase;Population;population health;Positioning Attribute;Process;programs;Research;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resources;Scientist;Selection Bias;Series;Services;skill acquisition;skills;Source;South Carolina;Statistical Data Interpretation;tool;Translational Research;translational scientist;Universities;virtual;voucher;Vulnerable Populations

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program  (BERD Core)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: GIANCOLA, SUSAN POLAND (contact)

PROJECT_TERMS: Accountability;Accounting;Address;American;Charge;Clinical Research;Collaborations;Common Good;Community Health;Competence;Data;Data Analyses;Data Collection;Decision Making;Delaware;design;Development;Effectiveness;Environment;Equity;Evaluation;Evaluation Research;Evaluation Studies;flexibility;Fostering;Friends;Funding;Goals;Health;health equity;Health Status;improved;Individual;Infrastructure;innovation;Institution;Investments;Leadership;meetings;Methods;Monitor;Outcome;Performance;Persons;Policies;Process;process improvement;Productivity;Professional Organizations;Program Evaluation;programs;Progress Reports;Publications;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Role;success;System;technical report;theories;translational impact;Translational Research;translational research program;United States National Institutes of Health;Work

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program (TEVAL Core)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

PI_NAMEs: PACHTER, LEE M (contact)

PROJECT_TERMS: Address;Administrator;Advocacy;Area;Award;base;Clinical;Clinical Research;Collaborations;Communities;community based research;community collaboration;community engaged research;community engagement;Community Outreach;community partners;community research;Complex;Consultations;Delaware;Development;Disparity;Educational workshop;Equity;Family;Funding;Goals;Grant;Growth;Health;Health Disparities Research;health equity;health inequalities;Health Personnel;Health system;improved;innovation;Institution;Knowledge;Lead;member;Mentors;Modeling;Neighborhoods;Outcome;patient engagement;Patients;Personal Satisfaction;Phase;Policy Maker;population health;Process;programs;Public Health;Research;research and development;Research Infrastructure;Research Personnel;research to practice;skills;social;Specialist;Time;Translating;translational pipeline;Translational Research;Trauma;Voice;Work

PROJECT_TITLE: Delaware Clinical and Translational Research ACCEL Program (CEO Core)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE This proposal is highly relevant to public health as the proposed studies are expected to elucidate the pivotal roles and underlying cellular and molecular mechanisms of the heparan sulfate expression in Aβ clearance and AD pathogenesis, which likely will contribute to the development of novel therapeutics for AD treatment.

PI_NAMEs: WANG, LIANCHUN  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Abeta clearance;Abeta synthesis;Acceleration;Advanced Development;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein;Basement membrane;Biochemical;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Diseases;brain dysfunction;brain endothelial cell;brain parenchyma;Cell surface;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular system;Complex;conditional knockout;Defect;Degenerative Disorder;demented;Deposition;Development;Disease;Drainage procedure;effective intervention;effective therapy;Event;Extracellular Matrix;Female;Genetic;Genetic study;glymphatic system;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Human;impaired capacity;Impairment;In Vitro;in vivo;Kinetics;Knock-out;Knockout Mice;LDL-Receptor Related Protein 1;Ligand Binding;Lipoprotein Receptor;male;Mediating;Membrane;Membrane Proteins;Molecular;Morphology;mouse model;Mus;Neurons;neurovascular;neurovascular unit;novel;novel therapeutics;overexpression;Pathogenesis;Pathology;Patients;Play;Polysaccharides;Production;Proteins;Public Health;receptor;Role;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Specimen;Structure;Sulfate;tau Proteins;Testing;Therapeutic Intervention;therapeutically effective;Tight Junctions;uptake;Vascular Smooth Muscle;Wild Type Mouse

PROJECT_TITLE: Heparan sulfate proteoglycan in the brain vascular clearance of amyloid-β and Alzheimer's disease


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE This secondary data analysis leverages data from an Alzheimer’s Disease Initiative funded Phase III randomized clinical trial examining benefits of transcranial direct current stimulation paired with cognitive training to remediate age-related cognitive decline and alter trajectories toward Alzheimer’s disease. Using advanced neuroimaging-derived computational modeling and artificial intelligence-based machine learning methods, the study will determine the mechanisms underlying response vs. non-response to treatment in older adults and precision dosing parameters for optimizing treatment outcomes.

PI_NAMEs: FANG, RUOGU  (contact);WOODS, ADAM J.

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Age;age related changes;age related neurodegeneration;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease risk;Anatomy;artificial intelligence model;Atrophic;Behavioral;behavioral outcome;Bilateral;Brain;Brain region;Characteristics;Clinical;Clinical Trials;Cognition;Cognitive;cognitive enhancement;Cognitive remediation;cognitive training;comorbidity;Computer Models;Computing Methodologies;cranium;Data;Data Analyses;Data Set;Dose;Educational Intervention;effective intervention;Effectiveness;Elderly;electric field;Electrodes;Elements;experience;Foundations;Funding;Future;Goals;Head;Heterogeneity;Image;Impaired cognition;Individual;Individual Differences;individual variation;insight;inter-individual variation;Intervention;intervention refinement;Learning;Left;Lesion;Liquid substance;Location;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measurement;Measures;Mental Health;Methods;mild cognitive impairment;Modeling;multimodal neuroimaging;Neuroanatomy;neuroimaging;Neuronal Plasticity;older adult;Outcome;Participant;Pathway interactions;Patients;Persons;Phase;Population;Positioning Attribute;precision medicine;predicting response;Prevalence;prevent;primary outcome;Property;Public Health;randomized, clinical trials;Readiness;remediation;Research;response;Sampling;Scalp structure;sex;Structure;support vector machine;System;targeted delivery;Thick;transcranial direct current stimulation;treatment optimization;Treatment outcome;treatment response;United States National Institutes of Health;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Mechanisms, response heterogeneity and dosing from MRI-derived electric field models in tDCS augmented cognitive training: a secondary data analysis of the ACT study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Complementary and Integrative Health;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NEUROSURGERY

PHR: Narrative Aging remains the most significant risk factor for Alzheimer’s disease (AD) and has recently been linked to gastrointestinal health of older people. Our study will examine connections between intestinal and brain inflammation, in mouse models of aging and AD, to determine how these connections affect aging-related cognitive decline and AD pathology. The proposed studies will determine whether increased gut permeability due to loss of the intestine’s protective mucus barrier accelerates aging-related cognitive decline and AD, and whether a new probiotic therapy, LpD3-5, can reverse these processes.

PI_NAMEs: YADAV, HARIOM  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Address;Affect;age acceleration;age related;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;APP-PS1;base;Basic Science;Brain;Cell Count;Cell Culture Techniques;Cell Lineage;Cell Wall;chemical synthesis;Chronic;Cognition;comparative;cost;Data;Development;Disease Marker;Disease Progression;Disease susceptibility;effective therapy;Encephalitis;Extravasation;feeding;G-Protein-Coupled Receptors;gastrointestinal;Goblet Cells;gut inflammation;gut microbiota;Health;Human;Impaired cognition;improved;In Vitro;Inflammation;insight;Intervention;Intestinal permeability;Intestines;Knowledge;Lactobacillus;Leaky Gut;Leucine-Rich Repeat;Link;lipoteichoic acid;Measures;microbial;mimetics;Modification;mouse model;Mucins;Mucous body substance;multidisciplinary;Mus;normal aging;novel;old mice;older adult;Older Population;Outcome Study;Pathogenesis;Pathway interactions;Permeability;Population;probiotic therapy;Probiotics;Process;Production;prophylactic;Public Health;rational design;Rationalization;Research Personnel;Risk Factors;Role;Severities;Signal Transduction;Sodium Dextran Sulfate;Source;stem cell differentiation;stem cells;Structure;systemic inflammatory response;Testing;Therapeutic;Time;TLR2 gene;transcription factor;Transgenic Mice;Translational Research;Variant;Work

PROJECT_TITLE: Microbial therapy improves gut permeability to reduce cognitive decline and Alzheimer’s disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Alzheimer’s disease (AD) is a multifactorial and complex neurodegenerative disorder that involves numerous genetic, epigenetic and environmental factors. In this proposal, we will study the function of a novel AD risk factor that we recently identified in order to understand how this gene functions together with other genetic factors that contribute to disease pathogenesis. This will lead to a deeper mechanistic understanding of AD and potentially to identification of novel targets for therapeutic interventions.

PI_NAMEs: YAMAMOTO, SHINYA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adult;Affect;age related decline;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Behavioral;Biochemical;Biological;Biological Assay;Biological Models;Brain;cell type;Cells;cohort;Collaborations;Compensation;Complex;Data;Defect;Development;Disease;Dominant-Negative Mutation;Drosophila genus;Drosophila melanogaster;Early Onset Alzheimer Disease;Electrophysiology (science);Embryo;Embryonic Development;Environmental Risk Factor;Enzymes;Epigenetic Process;Exhibits;experimental study;Extracellular Domain;Family member;Female;fly;Foundations;Gene Family;gene function;Genes;Genetic;Genetic Epistasis;genetic risk factor;genetic variant;genomic epidemiology;Genomics;Heart;Human;Human Amyloid Precursor Protein;in vivo;insight;Invertebrates;Knock-out;Late Onset Alzheimer Disease;life span;Link;loss of function;Maintenance;Mammals;Mediating;Membrane Proteins;Methodology;Methods;model organism;Molecular;Motor;Mus;mutant;Nerve Degeneration;Nervous System;neural;Neurodegenerative Disorders;neurodegenerative phenotype;Neurons;neurotoxic;new therapeutic target;notch protein;novel;Odds Ratio;Onset of illness;Other Genetics;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;Peptides;Phenocopy;Phenotype;Play;Postembryonic;Process;protein expression;Protein Family;Protein Precursors;Proteins;Proteolysis;rare variant;Reporter;Reporting;Research;Research Infrastructure;Risk;Risk Factors;Role;secretase;Signal Transduction;Testing;Therapeutic Intervention;Tissues;Variant;Vertebrates

PROJECT_TITLE: UNDERSTANDING THE ROLE OF TM2D FAMILY GENES IN NOTCH SIGNALING AND ALZHEIMER'S DISEASE

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative  The long-term objective of this proposal is to develop first-in-class, best-in-class noncoding RNA-based gene therapeutics with a novel mechanism of action, to improve standard of care for a broad range of blood and vascular diseases with unmet clinical need: management of thrombotic risk (blood clots), and management of bleeding disorders including bleeding caused by antithrombotic drugs. We have established for the first time a unique platform system of non-integrative, temporally controlled, tunable gene therapeutic reprogramming of blood platelets (the cells responsible for clot formation) and their parent cells megakaryocytes, which we have found is naturally selective for the megakaryocyte / platelet lineage without affecting other cell types, and which we have demonstrated yields strong antithrombotic and antibleeding therapeutic benefit. In this proposal, we will use mouse models of thrombosis and bleeding, including models of acquired and inherited bleeding disorders, to select novel RNA drug formulations with the strongest therapeutic benefits with limited risk of deleterious side effects, and we will determine efficiencies of different administration routes, which together will firmly set the stage to advance preclinical development of these novel antiplatelet drugs.

PI_NAMEs: GOLDFINGER, LAWRENCE E (contact);STALKER, TIMOTHY J.

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acceleration;Achievement;Acute;Address;Adjustment Disorders;ADP Receptors;Advanced Development;Affect;Affinity;Animal Model;Antiplatelet Drugs;Aspirin;Blood coagulation;Blood Coagulation Disorders;Blood Platelet Disorders;Blood Platelets;blood vessel occlusion;cell type;Cells;Clinical;Clinical Management;Clinical Trials;Coagulation Process;Data;Disease;Disease Management;Disease susceptibility;Dose;Drug Administration Routes;Drug Formulations;efficacy evaluation;Encapsulated;Fibrinolytic Agents;frontier;Gene Expression;Genes;Goals;Hematological Disease;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;improved;in vivo;Inflammatory Response;Inherited;inhibitor;Intravenous;Ischemia;Lead;Life;Limb structure;Liposomes;Megakaryocytes;Messenger RNA;Minor;Modeling;Molecular Target;Morbidity - disease rate;mouse model;Mus;nanoparticle;novel;novel strategies;novel therapeutics;Nucleotides;oligonucleotide therapeutics;Oligonucleotides;Parents;patient population;Patients;PAWR gene;Pharmaceutical Preparations;platelet function;precision medicine;preclinical development;prevent;programs;Property;receptor;Risk;Risk Management;RNA;Route;side effect;small molecule;Specificity;standard of care;Structure;subcutaneous;System;Technology;Testing;Therapeutic;therapeutic development;therapeutic gene;therapeutic RNA;therapeutic target;therapy development;therapy outcome;Thrombin Receptor;Thrombosis;thrombotic;Time;Tissues;Transfection;Untranslated RNA;uptake;Vascular Diseases;vascular injury

PROJECT_TITLE: RNA-based therapeutics for hemostasis and thrombosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Tet enzymes are epigenetic modifiers. They are highly expressed in embryonic stem cells and during development, particularly in the neural lineage. They promote DNA demethylation to regulate gene expression. Dysregulation or mutations of Tet enzymes have been linked to human craniofacial and neurodevelopmental disorders and many cancers. This proposal studies how various enzymatic activities of Tets regulate neural stem cell biology. Findings will broaden our knowledge of the epigenetic regulation of neural stem cells and nervous system development. This will have implications in identifying therapeutic targets for treatment of neurodevelopmental disorders as well as enhancing applications of neural stem cells for clinical use.

PI_NAMEs: EBERT, BLAKE C (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Affect;Apoptosis;Astrocytes;Attenuated;Biological;Biology;carboxylate;carboxylation;Categories;Cell Cycle;Cell Line;cell type;Characteristics;Clinical;craniofacial disorder;Cytosine;Data;Defect;demethylation;Development;differential expression;DNA;DNA Binding;DNA Methylation Regulation;Down-Regulation;Embryo;embryonic stem cell;Enzymes;Epigenetic Process;epigenetic regulation;Excision;Family;Gene Expression;Gene Expression Regulation;Genes;Genetic Engineering;Genome Mappings;genome-wide;Genomic Segment;Genomics;Goals;Human;human disease;Hydroxylation;Impairment;improved;In Vitro;Individual;Joints;Knowledge;Link;Maintenance;Malignant Neoplasms;Maps;Mediating;Mentorship;Methylation;Modeling;Molecular;Mus;mutant;Mutation;nerve stem cell;Nervous System;nervous system development;neural;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurons;novel;Oligodendroglia;Outcome;Pathway interactions;Phenotype;Physicians;Point Mutation;prevent;Process;programs;Proliferating;Proteins;Reader;recruit;Research;Role;Scientist;Self Assessment;self-renewal;skills;stem cell biology;stem cell genes;stem cell self renewal;Stem cell transplant;Testing;Tetanus Helper Peptide;therapeutic target;Thymine DNA Glycosylase;Tissues;Training;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Tet-mediated DNA hydroxylation vs formylation and carboxylation in NSC biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Public Health Narrative Due to a genetically induced imbalance in salt and water transport in cystic fibrosis (CF) lungs, mucus is dehydrated and the lungs fail to eradicate bacteria, leaving the airways prone to chronic infection and inflammation that ultimately destroy the lung. In this application, we propose to develop peptide-based therapies that can shift the lung’s immune balance to efficiently clear bacteria from the lung.

PI_NAMEs: TARRAN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute Respiratory Distress Syndrome;antagonist;Bacteria;Bacterial Infections;Binding;Biological Models;Birth;C-terminal;catalyst;Cell membrane;Chronic;chronic infection;Chronic Obstructive Pulmonary Disease;Clinical Trials;common symptom;COVID-19 patient;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis sputum;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;Dehydration;design;Dose;Drug Kinetics;druggable target;Equilibrium;experimental study;Formulation;Genes;Genetic Diseases;Grant;Immune;Immune response;Immunocompromised Host;Inflammation;Inflammatory;Inflammatory Response;Inhalation;inhibitor;Lead;Leukocyte Elastase;Lung;Lung Diseases;Lung infections;lung injury;Lysosomes;Maximum Tolerated Dose;Mediating;Metabolism;Modeling;Modification;mouse model;Mucous body substance;Mus;Mutation;Nasal Epithelium;neutrophil;Neutrophilia;Nonsense Mutation;Normal Range;novel;Palate;pathogen;Patients;Peptide Hydrolases;peptide structure;Peptides;peptidomimetics;peripheral blood;Phase;Physiological;Population;preservation;prevent;Proteins;Pseudomonas aeruginosa;Public Health;Pulmonary Cystic Fibrosis;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Rattus;Regulator Genes;Role;Safety;severe COVID-19;Signal Transduction;small molecule;Sodium Chloride;Solubility;Specificity;Sputum;Staphylococcus aureus;Structure;Testing;transcription factor;Water

PROJECT_TITLE: Optimizing ELD607 for Delivery by Inhalation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: The utility and cost effectiveness of vaccination has been shown multiple times and most recently during the COVID-19 pandemic. To be ready for the next pandemic, we need to ensure that there are sufficient individuals entering and staying in the field of vaccinology. The goal of the Integrated Training Program in Vaccinology (ITP- Vax) is to encourage more outstanding trainees to join the field of vaccinology and to enable our existing outstanding early-career vaccinologists to excel in mentorship and to become fully independent.

PI_NAMEs: TENNANT, SHARON MEI (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: 2019-nCoV;Academia;Acceleration;Address;African;American;Applications Grants;Area;Award;Black race;career;Clinical;Clinical Trials;cost effectiveness;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 vaccine;Creativeness;Dedications;design;Development;Disease;Diverse Workforce;Doctor of Philosophy;Education;Educational Activities;Educational process of instructing;Educational workshop;Ensure;experience;Feedback;Fright;future pandemic;Goals;Government;Health;Hispanic;Human;Immune response;Immunology;improved;Individual;Industry;Investments;Knowledge;Laboratory Personnel;Latino;Learning;Measles;medical schools;Mental Health;Mentors;Mentorship;Morbidity - disease rate;mortality;Native Americans;next generation;Normalcy;novel vaccines;Nurses;Pertussis;Poliomyelitis;Population;Postbaccalaureate;Problem Solving;Process;Productivity;professor;programs;Recording of previous events;recruit;Regulatory Affairs;Research;Research Personnel;Research Project Grants;Resources;Risk;RNA vaccine;skill acquisition;Smallpox;Societies;Specialist;Streptococcus pneumoniae;Students;Study Section;supply chain;synergism;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Vaccination;vaccine development;vaccine platform;Vaccines;vaccinology;Work

PROJECT_TITLE: Integrated Training Program in Vaccinology (ITP-Vax)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PP-D (M1)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: It is the goal of my laboratory, the VA/CU Biomechatronics Development Laboratory and I to innovate devices, interfaces, algorithms, and systems in the field of limb prosthetics to positively impact the lives of persons and veterans with limb loss. The care of Veterans with upper limb amputation requires a highly individualized approach. Due to the severity of impairment caused by upper-limb amputation, upper-limb prosthetics research and development is of particular significance to US veterans with upper-limb loss. Each Veteran brings unique needs to the clinic including level of amputation, lifestyle, personal experience, and other medical indicators making quality-of-life a primary driver of care. In our field of prosthetic care delivery, prosthetists and occupational therapists collaborate with each veteran to provide personalized solutions with the commercially available prosthetic componentry and technologies. Often, the bottleneck is the lack readily sourced clinically sound and relevant prosthetic components with which to provide an optimal prosthetic solution.

PI_NAMEs: WEIR, RICHARD FERGUS FFRENCH (contact)

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Algorithms;Amputation;Appointment;Architecture;Area;arm;Articulation;Award;Back;Belief;biomechanical model;Biomedical Engineering;blind;Blood Glucose;care delivery;career;Caring;Cells;Chicago;Cladribine;Clinic;Clinical;clinical development;clinical translation;clinically relevant;Collaborations;Complex;Consensus;Contracts;design;Development;Devices;Distal;Doctor of Philosophy;Elasticity;Esthesia;Exclusion;experience;Extramural Activities;Fingers;first-in-human;Forearm;Freedom;Funding;Fuzzy Logic;Goals;Grant;Hand;Healthcare;Heart;Iceland;Impairment;Implant;implantation;implanted sensor;improved;Individual;Inflammation;innovation;innovative technologies;interest;Joints;Laboratories;laboratory development;Lead;Licensing;Life Style;limb amputation;limb loss;Limb Prosthesis;Limb structure;Maps;Maryland;Mechanics;Medical;Medical center;meetings;Mentors;Metals;Methods;Michigan;Modeling;Motor;Muscle;Musculoskeletal Equilibrium;National Institute of Neurological Disorders and Stroke;Nature;Nerve;Nervous System;neural;Neurons;neuroregulation;novel;novel strategies;Occupational Therapist;Occupations;Optics;optogenetics;Pancreas;Paper;Pattern Recognition;Peripheral Nerves;personalized approach;Persons;Phantom Limb Pain;Physics;Post-Traumatic Stress Disorders;Postdoctoral Fellow;pressure;Printing;Process;prophylactic;Prosthesis;Prosthesis Design;prosthetic hand;Prosthetic rehabilitation;prototype;Provider;Publishing;Quality of life;Radial;regenerative;rehabilitation research;Research;research and development;research clinical testing;Research Personnel;Scientist;Secure;sensor;sensor technology;Sensory;sensory feedback;Series;Severities;Signal Transduction;Site;sound;Source;Students;Surface;Suspensions;System;Techniques;Technology;Time;Touch sensation;Training;Translating;Translations;United States National Institutes of Health;Upper Extremity;Vagus nerve structure;Veterans;Woman;Work;Wrist

PROJECT_TITLE: Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative Exercise is an effective intervention for both the prevention and treatment of heart and metabolic diseases. Our goal is to understand the fundamental mechanisms by which exercise confers its healthful benefits. A better understanding of exercise may identify those individuals who are most likely to derive benefit from intensive interventions or novel therapies to improve human health and longevity.

PI_NAMEs: CARR, STEVEN A;CLISH, CLARY B;GERSZTEN, ROBERT E (contact);NEWGARD, CHRISTOPHER B

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Adipocytes;Aminoisobutyric Acids;analytical tool;Animal Model;Animals;arm;Biochemical;Bioinformatics;Blood;Blood specimen;Cardiometabolic Disease;cardiometabolism;Chemicals;Chronic;clinical center;cohort;Collaborations;Communities;Coupled;COVID-19;Data;data integration;design;Dietary Intervention;Disease;disease phenotype;effective intervention;Exercise;exercise intervention;exercise prescription;experience;Family Study;Framingham Heart Study;Funding;Future;Generations;Genes;Genetic;Genomics;glucose disposal;Goals;Health;Health Benefit;Heart Diseases;Human;human disease;human tissue;improved;In Vitro;Individual;insight;Investigation;Jackson Heart Study;Leadership;Longevity;Manuscripts;Mediating;member;Mentors;Metabolic;Metabolic Diseases;metabolomics;Molecular;Molecular Profiling;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Mus;National Heart, Lung, and Blood Institute;next generation;novel;novel therapeutics;Organ;Phase;Phenotype;Plasma;Play;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;Precision Health;precision nutrition;Preparation;Prevention;programs;protein profiling;Proteomics;Records;Research;Research Personnel;response;Risk Factors;Role;Sampling;Science;Signal Transduction;Site;small molecule;Technology;Therapeutic Intervention;Tissue Sample;Tissues;tool;Trans-Omics for Precision Medicine;Transducers;translational scientist;Weight Gain;Work;working group

PROJECT_TITLE: A biochemical roadmap of exercise signal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-A (51)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Our proposed research is in-line with the mission of the NEI to advance knowledge of the neural mechanisms of the visual system. We expect our proposed research to significantly advance the understanding the relation between structure, function and computation. The outcome of our research will improve the well-being of individuals in society as it will provide foundational knowledge that can lead to the identification of neurodiagnostic markers of tissue structure and function that can be measured non- invasively within individuals.

PI_NAMEs: GRILL-SPECTOR, KALANIT  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Administrative Supplement;Anatomy;artificial neural network;Attention;autism spectrum disorder;Award;Behavior;Brain;Clinical;Code;computer framework;Computer Models;Computers;computing resources;cortex mapping;cost;Data;data acquisition;Dedications;deep neural network;developmental prosopagnosia;Diffusion;Diffusion Magnetic Resonance Imaging;Dyslexia;Face;falls;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Grant;Hour;Human;improved;in vivo;Individual;innovation;Journals;Knowledge;Lateral;Length;Linux;Magnetic Resonance Imaging;Manuscripts;Maps;Measures;Methods;millisecond;Mission;Modeling;multimodality;neural;neural model;Neuroanatomy;neuroimaging;neuromechanism;Outcome;Peer Review;Perception;Personal Satisfaction;Population;Positioning Attribute;post-pandemic;predicting response;Preparation;Property;Publications;Publishing;receptive field;Reporting;repository;Research;Resources;response;scaffold;Scanning;segregation;Societies;spatiotemporal;stem;STEM research;Stimulus;Stream;structural determinants;Structure;Temporal Lobe;Testing;Tissues;Training;Vision;Visual;Visual Cortex;Visual Fields;visual processing;visual stimulus;Visual System;white matter

PROJECT_TITLE: Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Oropharyngeal cancer (OPC) is commonly associated with Human Papilloma Virus (HPV) infection. The goal of this work is to understand how oropharyngeal cancer (OPC) is initiated when an individual is already infected with another chronic virus like HIV. These studies will identify early virus induced changes in the host that lead to OPC.

PI_NAMEs: BANERJEE, NILAM SANJIB;BANSAL, ANJU  (contact);GOEPFERT, PAUL A.

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 3-Dimensional;Acceleration;Activities of Daily Living;Antigens;antiretroviral therapy;Antitumor Response;Blood;cancer initiation;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle;Cell Cycle Progression;cell transformation;Cells;Chronic;chronic infection;Clinical;co-infection;Coupled;Data;Development;Distant;DNA biosynthesis;Early identification;Epithelial Cells;Epithelium;Equilibrium;exhaust;exhaustion;Exposure to;Functional disorder;Functional impairment;Gender;Gene Expression;General Population;Genetic Transcription;Genotype;Goals;Head and Neck Cancer;high risk;HIV;HIV Envelope Protein gp120;HIV Infections;HIV tat Protein;HPV oropharyngeal cancer;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immune;immune activation;Immune Evasion;Immune System Diseases;Immunity;Immunocompromised Host;Immunohistochemistry;Immunologic Factors;Immunologic Surveillance;Impairment;improved;Individual;Infection;Infiltration;Inflammation;insight;Intervention;Life Cycle Stages;Literature;Malignant - descriptor;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Modeling;neoplastic cell;Oncogenes;Oncogenic;Oncoproteins;Oropharyngeal;Outcome;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Predisposition;premalignant;Premalignant Cell;Prevalence;Prevention;Probability;Process;Production;Prognosis;Proliferating;prospective;Proteins;Publishing;racial diversity;reconstitution;Research Design;restoration;Retinoblastoma Protein;Retrospective Studies;Specimen;Stains;T-Lymphocyte;Testing;TP53 gene;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;tumorigenesis;Viral;viral DNA;virome;Virus;Work

PROJECT_TITLE: Onco-immunologic factors contributing to OPSCC among people living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (10)]


ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: Project Narrative: The Research Education Program on Microbes, Infections and Cancer (REPMIC) within the University of Puerto Rico Comprehensive Cancer Center will be the first research training program in Puerto Rico focused on recruiting underserved and minority college graduates to participate in a 9-month postbaccalaureate program designed to provide them with hands-on research experiences within the field of microbes, infections and cancer. Educational activities will be provided to help them apply and be successful in a Ph.D. program and/or in a health professions degree program. REPMIC will contribute to the next generation of cancer and infectious disease researchers and the diversification of the biomedical and public health research workforce.

PI_NAMEs: ORTIZ, ANA PATRICIA (contact);SOTO-SALGADO, MARIEVELISSE

PROJECT_TERMS: Adoption;Advanced Malignant Neoplasm;Affect;anti-cancer research;Applied Research;Area;Award;Bacteria;Basic Science;Biological Markers;Biomedical Research;cancer care;Cancer Control;Cancer Control Research;cancer education;cancer prevention;career;career development;Centers for Disease Control and Prevention (U.S.);Clinical;Collaborations;college;Communicable Diseases;Comprehensive Cancer Center;Continuity of Patient Care;Credentialing;Degree program;design;Development;Discipline;Disease;Doctor of Philosophy;Education;education research;Educational Activities;Educational workshop;experience;Exposure to;follow-up;Future;Genetic Determinism;Goals;Graduate Degree;hands on research;Health;health disparity;Health Occupations;Health Professional;higher education;Hispanic Populations;HIV;Human;Human Microbiome;Human Papillomavirus;Individual;Infection;infection related cancer;innovation;insight;Institution;interest;Knowledge;Letters;Link;Malignant Neoplasms;meetings;Mentors;Microbe;Microbial Genetics;microbiome;Minority;Minority Groups;Mission;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;Oncology;Outcome;Participant;Pathology;Pathway interactions;Patient Recruitments;Performance;Play;population based;Population Research;Postbaccalaureate;prevent;Principal Investigator;Privatization;Process;Productivity;professional students;Program Evaluation;programs;Public Health;public health research;Publications;Puerto Rico;Recommendation;recruit;Research;Research Personnel;Research Training;Role;satisfaction;Science;skills;Surveys;Talents;Target Populations;therapeutic target;Training;Training Programs;treatment response;tumor progression;tumorigenesis;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Virus

PROJECT_TITLE: Research Education Program on Microbes, Infections, and Cancer (REPMIC)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention

ORG_CITY: STANFORD

PHR: Narrative The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is collecting a large and complex multiomic dataset to understand how tens of thousands of molecules change in response to exercise. The Stanford Bioinformatics Center aims to serve MoTrPAC by organizing, analyzing, and sharing this vast collection of data. This work ensures that the results of the Consortium are robust, reliable, valid, and available and usable by the entire scientific community.

PI_NAMEs: ASHLEY, EUAN A (contact);WHEELER, MATTHEW THOMAS

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Adopted;age group;Bioinformatics;bioinformatics resource;bioinformatics tool;Chemicals;Clinical Data;cloud based;Code;Collaborations;Communities;Complex;complex data;computerized data processing;Data;Data Analyses;Data Collection;Data Coordinating Center;data dissemination;data ecosystem;data harmonization;data hub;data integration;data integrity;data management;Data Management Resources;data pipeline;data resource;Data Set;data sharing;data standards;Data Storage and Retrieval;data tools;data visualization;database of Genotypes and Phenotypes;Development;differential expression;Dimensions;Documentation;Education and Outreach;Educational workshop;Ensure;epigenomics;Exercise;experience;FAIR principles;Feedback;Funding;Future;Genomics;Health Benefit;human data;improved;Infrastructure;innovation;insight;instrument;Language;Leadership;metabolomics;Metadata;Methods;Mission;Modality;Molecular;multidimensional data;Multiomic Data;multiple omics;Nature;novel;Online Systems;Organizational Efficiency;Outcome;outreach;Phase;Phenotype;Physical activity;Positioning Attribute;Privacy;Proteomics;Publications;quality assurance;Quality Control;Randomized, Controlled Trials;Regulation;repository;Reproducibility;Research;Resources;response;Retrieval;Science;Secure;Services;Site;success;symposium;System;Techniques;Time;Tissues;tool;Training;transcriptomics;Transducers;United States National Institutes of Health;usability;Vision;Visualization;Work

PROJECT_TITLE: Molecular Transducers of Physical Activity (MoTrPAC)


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Sepsis

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative For early diagnosis of potentially life-threatening bacteremia and combating antibacterial resistance, we propose to develop an integrated molecular and single-cell detection platform that can rapidly identify the causative bacteria and promptly test the susceptibilities of the identified bacteria against various antibacterial agents. Timely diagnosis of bacteremia with the proposed platform can transform acute-care clinicians’ ability to treat patients with appropriate drugs, thus improving treatment outcome and curtailing the emergence of antibacterial resistant bacteria.

PI_NAMEs: WANG, TZA-HUEI JEFF  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Acute;acute care;Anti-Bacterial Agents;antimicrobial;Automation;Bacteremia;Bacteria;Bacterial DNA;Bacterial Drug Resistance;Bacterial Infections;bacterial resistance;Biological Assay;Blood;Blood specimen;Blood Volume;Buffers;Caring;Cause of Death;Cell Separation;Cell Survival;Cells;Clinical;clinical diagnostics;Code;Collaborations;Color;Companions;cost;Cytolysis;Data;design;Detection;detection assay;detection platform;Devices;Diagnosis;diagnosis standard;Diagnostic;diagnostic assay;diagnostic platform;diagnostic technologies;digital;DNA;DNA Probes;Early Diagnosis;Engineering;Fluorescence;Genotype;Hospitals;Hour;Iatrogenesis;Image;Impairment;improved;Individual;Infection Control;instrument;Laboratories;Life;Magnetism;Measures;Medicine;melting;Methods;Microfluidic Microchips;Microfluidics;miniaturize;Modern Medicine;Molecular;molecular diagnostics;Multi-Drug Resistance;multi-drug resistant pathogen;multidisciplinary;Multiple Bacterial Drug Resistance;multiplex detection;operation;optical imaging;Outcome;particle;pathogen;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;portability;Predisposition;Preparation;Probability;prospective;Protocols documentation;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Ribosomal DNA;Ribosomal RNA;RNA, Ribosomal, 16S;Sampling;Science;Sepsis;Specific qualifier value;Speed;Superbug;Surrogate Markers;Technology;Temperature;Testing;Time;Treatment outcome;Validation;validation studies

PROJECT_TITLE: Integrated genotype-informed single-cell molecular antibacterial susceptibility testing platform for rapid and actionable diagnosis of bacteremia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PUBLIC HEALTH RELEVANCE The number of cancer survivors with cardiovascular risks has increased substantially and CVD mortality has surpassed cancer mortality for many cancer sites. Cancer survivors often become disconnected from their primary care providers during cancer treatment and forego necessary chronic disease care. This study tests health system strategies to improve primary care connection during cancer treatment and has potential to impact implementation strategies used throughout U.S. health systems to reduce cardiovascular risks for cancer survivors.

PI_NAMEs: FERRANTE, JEANNE M;HUDSON, SHAWNA V.;O'MALLEY, DENALEE M. (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Acceleration;Address;Adoption;Attention;Breast;cancer care;cancer diagnosis;Cancer Institute of New Jersey;cancer site;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care coordination;care delivery;care systems;Caring;Chronic;Chronic Disease;Clinical;Communication;comorbidity;Complex;Comprehensive Cancer Center;connected care;contextual factors;design;Development;Development Plans;Diabetes Mellitus;Diagnosis;diaries;Disease Management;Effectiveness;effectiveness testing;effectiveness/implementation study;Endometrial Carcinoma;Enrollment;ethnic minority;Evaluation;evidence base;General Practitioners;Guidelines;Health;health disparity populations;Health Priorities;Health system;Hybrids;Hyperlipidemia;Hypertension;implementation context;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Interdisciplinary Study;Intervention;Interview;Learning;low socioeconomic status;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measures;Medical Care Team;medical specialties;member;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;multiple chronic conditions;Nurses;Oncology;patient oriented;Patient Outcomes Assessments;Patients;Population;Positioning Attribute;Primary Care;primary care practice;primary care provider;primary care team;primary care visit;primary outcome;Process;Prostate;Protocols documentation;public health relevance;racial minority;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;Research Design;research study;Risk;Risk Factors;secondary outcome;Self Efficacy;Service delivery model;Shapes;standardized care;Surveys;Survivors;survivorship;System;team-based care;Testing;theories;therapy design;tool;translational potential;treatment as usual;Treatment Protocols;Visit;Wood material

PROJECT_TITLE: ACCESS-PC: Advancing Care Coordination to Enhance Shared Care for Complex Survivors in Primary Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health as we will define metabolic mechanisms involving in locus coeruleus (LC) neuron death. LC neuron dysfunction and degeneration are among the earliest neuropathological events in Alzheimer’s Disease (AD) and AD-related dementias (ADRD). A fuller understanding of mechanisms involved in LC vulnerability in brain health and disease will establish a foundation for the development of new therapeutics for a broad range of diseases including AD/ADRD.

PI_NAMEs: MORROW, ERIC M (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;Adult;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Astrocytosis;astrogliosis;Brain;Brain Diseases;brain health;Cell Death;cell type;Cells;Clinical;Data;Defect;Development;Disease;Disease Progression;Down's Syndrome;Electrophysiology (science);Environment;Enzymes;Event;Exhibits;experimental study;Foundations;Functional disorder;Genes;Germ Lines;Gliosis;Glutamates;Health;Heterozygote;human disease;improved;Intervention;Knockout Mice;Laboratories;large datasets;life span;Link;locus ceruleus structure;Measures;Mediating;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Mitochondria;Modeling;mouse model;mouse Ts65Dn;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;noradrenergic;novel;novel therapeutics;Parkinson Disease;Partner in relationship;Pathway interactions;postnatal;prevent;Prevention strategy;preventive intervention;Preventive treatment;Public Health;Pyruvate;Research;response;Sleep;Slice;Stress;stressor;Testing;Tg2576;Transaminases;transcriptomics;Translating;Validation;Wakefulness

PROJECT_TITLE: Metabolic Mechanisms in Locus Coeruleus Neuron Vulnerability in Neurodegenerative Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]