NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Administrative Personnel;Administrative Supplement;Award;Benchmarking;Biomedical Research;Centers of Research Excellence;Collaborations;Complex;Conflict of Interest;Data Collection;Decision Making;Discipline;Education;Educational workshop;Ensure;Evaluation;experience;Faculty;Feedback;Funding;Funding Mechanisms;Goals;Grant Review;improved;Incentives;innovation;Institution;Interdisciplinary Study;Kansas;Laboratories;Leadership;National Institute of General Medical Sciences;Oklahoma;operation;Participant;programs;Recording of previous events;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Rural Community;Scholarship;Science;Scientist;Signal Recognition Particle;Students;success;Supervision;symposium;Training;Training and Education;training opportunity;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;underserved community;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: STANFORD, JOHN A (contact)

PROJECT_TERMS: Administrative Supplement;Advertising;Applications Grants;Area;Award;Biomedical Research;career;career development;Collaborations;Compensation;Data Science Core;Development;Development Plans;Eligibility Determination;Ensure;Evaluation;experience;Faculty;faculty support;Feedback;Financial Support;Funding;Funding Agency;Funding Mechanisms;Funding Opportunities;Goals;Grant;inclusion criteria;innovation;Institution;Interdisciplinary Study;Kansas;Laboratories;Laboratory Research;Lead;Leadership;Logistics;meetings;member;Mentors;Mission;Monitor;Pilot Projects;Postdoctoral Fellow;Program Research Project Grants;programs;Research;Research Assistant;Research Personnel;Research Project Grants;Research Proposals;Resources;response;Science;skills;Source;Specific qualifier value;Students;success;symposium;Time;tool;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Wages;Writing

PROJECT_TITLE: Developmental Research Project Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BROWN, SUSAN J. (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Award;Bachelor's Degree;Big Data;Biochemistry;Bioinformatics;Biological;Biological Sciences;Biology;Biomedical Research;Biometry;career;Collaborations;Complex;computer infrastructure;Computer software;Computers;computing resources;Course Content;cyber infrastructure;Data;Data Analyses;Data Science;Data Science Core;data science education;data science infrastructure;data science resource;Data Scientist;Data Set;Databases;Degree program;design;Development;developmental genetics;distinguished professor;diverse data;Education;Educational Curriculum;Educational workshop;Ensure;experience;Experimental Designs;Faculty;Fostering;Genome;genome sequencing;Genomics;Goals;Healthcare;Informatics;Infrastructure;innovation;Institution;Investments;Kansas;large datasets;Leadership;Machine Learning;Maps;Master of Science;mid-career faculty;Molecular;multidisciplinary;multiple omics;next generation;Participant;Persons;practical application;Preparation;Process;professor;programs;Publications;Quantitative Genetics;Recording of previous events;Research;Research Personnel;Research Support;Resources;Scholarship;Science;science education;Scientist;Site;Specialist;Statistical Data Interpretation;Students;System;Techniques;Technology;Training;Training and Education;training opportunity;Training Programs;transcriptomics;undergraduate research;undergraduate student;Universities;Work;Workforce Development

PROJECT_TITLE: Data Science Core


PI_NAMEs: BALTHAZOR, JAMES R (contact)

PROJECT_TERMS: Affect;Air;Ally;Anatomy;animal facility;Area;Award;base;Biomedical Research;Chemicals;Chemistry;Computer Systems;cost;Custom;Dangerousness;design;Drainage procedure;Drops;Equipment;Faculty;Functional disorder;Generations;Growth;Health;improved;Incentives;Infrastructure;Institution;instrument;instrumentation;Joints;Kansas;Laboratories;laboratory facility;Laboratory Research;Liquid substance;Location;Microbiology;Modernization;Nitrogen;Noble Gases;Physiology;Plumbing;Productivity;Program Research Project Grants;Research;research faculty;Research Infrastructure;Research Personnel;Review Committee;Safety;Science;Secure;Students;System;undergraduate student;Universities;Update;Vacuum Pumps;Vent;Vertebral column

PROJECT_TITLE: A&R FHSU


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This study will evaluate and refine an artificial intelligence computer program (an “algorithm”) that can quickly read thousands of CT scans to look for calcium deposits in heart arteries to better predict heart attacks, strokes, and death. The study will also hold focus groups to identify the best way for patients and their doctors to use the information from the algorithm to initiate treatment for heart disease prevention. If the algorithm works as expected, it could be used to automatically screen millions of patients from diverse backgrounds who are unaware of their risk for heart disease and guide them toward lifesaving treatment.

PI_NAMEs: BANERJEE, IMON ;CHAUDHARI, AKSHAY ;RODRIGUEZ, FATIMA  (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Adult;Agatston Score;Age;Algorithms;Arterial Fatty Streak;Artificial Intelligence;Atherosclerosis;calcification;Calcium;Calibration;Cardiology;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cessation of life;Chest;chest computed tomography;Clinic;clinical practice;cohort;Communication;community partnership;comorbidity;computer program;Coronary artery;coronary artery calcium;Data;Data Science;deep learning;deep learning algorithm;Deposition;design;Detection;Dose;Electronic Health Record;Eligibility Determination;Encounter Groups;Epidemiology;Equation;Equity;Ethnic Origin;Evaluation;Evaluation Studies;Event;Focus Groups;follow-up;Geography;Health;Health Alliance;health care service utilization;health equity;Health system;Healthcare;heart disease prevention;heart disease risk;high risk;Image;imaging biomarker;implementation framework;improved;Individual;innovation;insight;Insurance;Intervention;Joints;Language;Learning;Life;low dose computed tomography;Low Dose Radiation;lung cancer screening;Malignant neoplasm of lung;Manuals;marginalized population;Measures;Methods;minority health;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Myocardial Infarction;Notification;novel;patient oriented;patient population;Patients;Phase;Population;Population Heterogeneity;preference;Prevalence;Prevention;Preventive;preventive intervention;Preventive therapy;Primary Prevention;prognostic value;Qualitative Methods;Qualitative Research;Race;Radiation;Radiology Specialty;Randomized;recruit;Reporting;Risk;Risk Assessment;Risk Estimate;risk prediction;risk prediction model;risk sharing;Scanning;screening;screening program;Severities;sex;shared decision making;Site;sociodemographic factors;Stroke;stroke patient;Symptoms;Testing;tool;Underrepresented Populations;usual care arm;Validation;virtual platform;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Novel Incidental Calcium Evaluation (NICE)

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Parent Project Narrative Emotional experience changes in advanced adulthood, where emotional deficits may predate neuropsychiatric disorders. The brain and autonomic nervous system cohesively interact to support social-emotional well-being. Cutting-edge analytical techniques can now reveal the dynamic properties of these systems. I propose to determine how autonomic and functional brain network dynamics shape human emotions in older adults and to assess how these neural systems are impacted by loneliness.

PI_NAMEs: PASQUINI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Affect;Affective Symptoms;Alzheimer's Disease;Anterior;Anxiety;Autonomic nervous system;Brain;Computing Methodologies;COVID-19 pandemic;Dementia;depressive symptoms;design;emotion regulation;Emotional;emotional experience;emotional functioning;emotional stimulus;Emotions;experience;Feeling;Functional Magnetic Resonance Imaging;Goals;Human;Impaired cognition;Life;life span;Loneliness;modifiable risk;Moods;Motivation;Nature;neural;neuropsychiatric disorder;older adult;Older Population;parent grant;parent project;Participant;Physiology;positive emotional state;Process;Property;recruit;Regulation;Reporting;Rest;Risk Factors;satisfaction;Shapes;social;Social Behavior;Social isolation;Social Network;Support System;System;Techniques;Well in self

PROJECT_TITLE: Dynamic neural systems udnerlying social-emotional functions


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE (Parent) The proposed study will provide essential information regarding which intervention targets and strategies are most likely to improve receipt of preventive services and ultimately reduce morbidity among children with SCA. We will use quantitative methods to identify critical targets within the healthcare delivery system, as well as key subgroups of the population, that can be intervened upon to improve the receipt of preventive services, and qualitative methods to identify barriers and facilitators to receipt of these services. We will integrate the findings from the quantitative analysis with the results from the qualitative analysis to fill the gap in understanding specific targets within the healthcare system, key population subgroups, and feasible strategies for interventions to maximize the receipt of preventive services among children with sickle cell anemia.

PI_NAMEs: REEVES, SARAH LEASURE (contact)

PROGRAM_OFFICER_NAME: HARDING, BRENDA

PROJECT_TITLE: Opportunities to optimize the receipt of preventive services among children with sickle cell anemia: A Mixed Methods Approach

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Nutrition

ORG_CITY: BATON ROUGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Narrative The current project will determine whether dietary protein restriction exerts persistent effects on protein motivation and its physiological correlates following normalization of protein intake.

PI_NAMEs: SOTO, PAUL  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TITLE: Persistent Effects of Dietary Protein Restriction on Protein Motivation and Underlying Physiology

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The proposed research will investigate the chemosensory and behavioral mechanisms in mice associated with the detection and perception of threatening predatory chemosignals. Chemosensation plays an important role in human well-being, including detecting dangers, food preferences, alcohol consumption, maternal bonding, and lifespan. Investigating how chemosensation contributes to social behavior can help us understand the human brain better and provide important insights that can improve the well-being of humans with chemosensation dysfunction and neurodegenerative disorders.

PI_NAMEs: WANG, JINXIN  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Afferent Neurons;Alcohol consumption;analysis pipeline;analytical tool;Animal Behavior;Animals;Behavior;Behavior assessment;Behavioral;Behavioral Assay;Behavioral Mechanisms;behavioral response;Bile Acids;Brain;Brain region;candidate identification;career;Cells;Chemicals;Comprehension;Computer software;Coupled;Crotalus;Cues;Data;data tools;Detection;Diet;Dipeptides;Environment;Esthesia;experimental study;Exposure to;Fatty Acids;Feces;Food Preferences;Foundations;Functional disorder;Future;Genetic Recombination;Goals;Grant;Grooming;Human;Hybrids;Image;improved;in vivo;Individual;information processing;Insecta;insight;Kairomones;Knowledge;life span;Ligands;Lighting;Link;liquid chromatography mass spectrometry;Lizards;Machine Learning;machine learning model;Mammals;Maternal Behavior;Mediating;Metabolic;Methods;Microscopy;Monitor;Mus;neural;neural circuit;Neurodegenerative Disorders;novel;Odors;Olfactory Pathways;Pathway interactions;Pattern;Perception;Personal Satisfaction;Pheromone;Play;Population;Process;receptor;Reptiles;Research;Research Personnel;Resolution;response;Risk;Risk Assessment;Role;Sensory;sensory mechanism;Signal Transduction;Smell Perception;Snakes;social;Social Behavior;social influence;Social Interaction;Solid;stool sample;Techniques;tomography;Transgenic Mice;Turtles;two-photon;unsupervised learning;vomeronasal organ

PROJECT_TITLE: Exploring the mechanism of chemosensory detection of threatening kairomones and associated behavioral responses

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Relevance to Public Health  Defects in calcium signaling can lead to a variety of diseases that include cancer, Alzheimer’s diseases, and cardiovascular diseases. Proper calcium signaling is also critical for the pathogenicity of many micro-organisms. This project will increase our understanding of calcium signaling, provide new insights for disease mechanisms, and identify novel targets for the development of anti-fungal drugs.

PI_NAMEs: WANG, YUQI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Alzheimer's Disease;anti-fungal agents;anti-microbial drug;Biochemical;Bioinformatics;Biological Process;Calcineurin;Calcium;Calcium Channel;calcium indicator;Calcium ion;Calcium Signaling;Cardiac Myocytes;Cardiovascular Diseases;Cations;cell type;Cell Wall;Cessation of life;Chitin;Communication;Cryptococcus;Cryptococcus neoformans;Defect;Development;Disease;Drug Targeting;Educational Curriculum;endoplasm;Enzyme Activation;Escherichia coli;Family;Genes;Golgi Apparatus;Growth;Health;Homologous Gene;Human;human disease;Immunocompromised Host;Impairment;improved;insight;Intervention;Maintenance;Malignant Neoplasms;member;Metabolism;microorganism;Mitochondria;mitochondrial metabolism;Names;Neurons;novel;novel therapeutics;Organelles;Organism;pathogen;pathogenic fungus;Pathogenicity;Persons;Phosphorylation Site;Phylogenetic Analysis;Play;Proteins;Public Health;pyruvate dehydrogenase;Regulation;Research;respiratory;Role;Sequence Analysis;Signal Transduction;Testing;thermal stress;virtual;Virulence;Work;Yeasts

PROJECT_TITLE: Characterizing the Function and Regulation of Ycx1, a New Member of the CCX Family of Exchangers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The overarching goal of the Brigham and Women’s Hospital/Harvard Medical School Roybal Center for Therapeutic Optimization using Behavioral Science is to continue to develop principle-driven interventions to enhance the evidence-based use of prescription medications. The structure and activities of the proposed Center will be based upon 4 key principles: (1) a multi-disciplinary approach; (2) the testing of principle-driven interventions in real-world settings; (3) the explicit testing of mechanisms of action, and (4) the use of novel analytic methods and technological approaches to gain a deeper understanding of behavioral mechanisms and to personalize interventions. The principle-driven interventions developed by our Center will readily translate to improvements in healthy aging and will also advance our fundamental understanding of how health behaviors can be effectively sustained.

PI_NAMEs: CHOUDHRY, NITEESH K (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adherence;age related;analytical method;Area;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;Behavioral Sciences;Benefits and Risks;Cardiovascular system;Clinical;clinical practice;collaboratory;Communities;computer science;COVID-19 pandemic;Data;Data Science;Development;Discipline;Drug Prescriptions;Ensure;Equilibrium;evidence base;Evolution;Funding;Geriatrics;Goals;Guidelines;Health;Health behavior;health care delivery;healthy aging;high risk;Hospitals;Impaired cognition;implementation research;improved;Individual;Infrastructure;Institution;interdisciplinary approach;Intervention;Knowledge;Learning;Maintenance;medical schools;Medicine;middle age;Monitor;Morbidity - disease rate;mortality;Motivation;multidisciplinary;multiple chronic conditions;novel;novel strategies;older adult;Outcome;Patient Compliance;Patient Noncompliance;Patients;Peer Review;personalized intervention;Pharmaceutical Preparations;Population;population health;Preventive therapy;programs;Provider;Psychology;Publications;Recommendation;Research;Research Personnel;response;Rewards;Structure;success;System;Technology;Testing;theories;Therapeutic;therapy design;therapy development;Translating;translational research program;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: The Roybal Center for Therapeutic Optimization using Behavioral Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J3)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Dissemination and Implementation Research

PROJECT_TERMS: age related;analytical method;behavior change;Behavior Therapy;behavioral and social science;Behavioral Mechanisms;Behavioral Model;Behavioral Sciences;Center for Translational Science Activities;Clinical;collaboratory;Committee Members;Communication;community collaboration;COVID-19 pandemic;design;digital technology;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Drug Prescriptions;Ensure;Environment;evidence base;Evolution;experience;Foundations;Funding;Geriatrics;Goals;Growth;health equity;Health system;Hospitals;implementation research;Individual;Industry;Infrastructure;Institution;Insurance Carriers;interdisciplinary approach;interest;Intervention;Knowledge;Leadership;Learning;Medicine;Monitor;multidisciplinary;novel;organizational structure;Patients;Peer Review;Pharmaceutical Preparations;Positioning Attribute;Process;programs;Psychology;Publications;Research;Research Personnel;Research Proposals;response;Science;Selection Criteria;statistics;success;Technology;Testing;theories;Therapeutic;therapy development;translational research program;United States National Institutes of Health;Woman;Work


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Prevention;Primary Health Care

PI_NAMEs: LAUFFENBURGER, JULIE CHRISTINE (contact)

PROJECT_TERMS: Adherence;advanced analytics;Anti-Cholinergics;approach behavior;Area;arm;behavior change;behavior influence;behavior test;Behavior Therapy;Behavioral;behavioral economics;Behavioral Sciences;Benzodiazepines;cardiometabolism;Caring;Characteristics;Cholesterol;Chronic;Classification;Communication;Data;Diabetes Mellitus;Discipline;Doctor of Pharmacy;Doctor of Philosophy;Drug Prescriptions;Effectiveness;effectiveness evaluation;Electronic Health Record;Eligibility Determination;Ensure;Evaluation;evidence base;experience;extrinsic motivation;Feedback;follow-up;Funding;Future;Goals;Health;Healthcare Systems;high risk;Hospitals;human old age (65+);hypnotic;improved;Individual;Industry;Infrastructure;innovation;Institution;Intervention;Learning;Machine Learning;Maintenance;Measures;medical schools;Medicare;medication compliance;Morbidity - disease rate;multidisciplinary;novel;Oral;Outcome Measure;Outpatients;Pathway interactions;patient response;patient subsets;Patients;personalized intervention;Pharmaceutical Preparations;pragmatic randomized trial;pragmatic trial;primary care provider;programs;Provider;Psychological reinforcement;Randomized;randomized trial;Research;Research Personnel;sedative;Services;Surveys;Technology;Testing;Therapeutic;therapy development;Time;tool;Translating;treatment as usual;two-arm trial;United States National Institutes of Health;Use Effectiveness;Woman

PROJECT_TITLE: Behavioral Intervention Development Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE – OVERALL Congenital cytomegalovirus (cCMV) is the leading global infectious cause of birth defects, hearing loss, and long-term neurologic deficits in infants exposed during gestation. Despite being considered a top priority for several decades, development of an effective CMV vaccine has been limited due to a gap in understanding of protective immune responses and virologic determinants of congenital CMV transmission. This Program will identify new antigen targets and immunization strategies for CMV vaccines to prevent and reduce cCMV infection, guiding design and clinical trial testing of next generation HCMV vaccines to prevent congenital CMV transmission.

PI_NAMEs: PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immunity;Address;Affect;Animal Model;Antibodies;Antibody Response;Antigen Targeting;Bioinformatics;Biological Models;Brain Injuries;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;chemokine;Chronic;Clinical Trials;Complex;Congenital Abnormality;congenital cytomegalovirus;Containment;cost;CXC Chemokines;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data Science Core;design;Development;Disease;disease transmission;efficacy study;efficacy trial;Engineering;Epidemiology;Epithelial Cells;Evaluation;Fc Receptor;Fetal Diseases;Fetus;Glycoproteins;Goals;Grant;hearing impairment;Homologous Gene;Human;Immune;Immune Evasion;Immune response;Immune Targeting;Immunity;Immunocompetent;Immunologic Factors;Immunologics;Impairment;improved;in utero;Infant;infant infection;Infection;Macaca mulatta;Maternal-Fetal Exchange;Maternal-Fetal Transmission;mathematical model;Mediating;Modeling;Neurologic;Neurologic Deficit;neutralizing antibody;Newborn Infant;next generation;nonhuman primate;novel;novel strategies;novel vaccines;Organoids;phase III trial;Placenta;Pregnancy;prevent;Primary Infection;Program Research Project Grants;programs;Proteins;Research;Risk;Role;Sequence Analysis;T cell response;T-Lymphocyte;Testing;trafficking;translational study;transmission process;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;vaccine development;vaccine-induced immunity;Vaccines;Viral;Viral Load result;Viral Pathogenesis;Viral Physiology;viral transmission;virology;Virus;Woman

PROJECT_TITLE: Immunologic strategies to prevent congenital cytomegalovirus transmission and disease in rhesus monkeys

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LG-M (J1)]


NIH_SPENDING_CATS: Data Science;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related

PROJECT_TERMS: Accounting;Agreement;animal resource;arm;Biological Models;Child;Collaborations;Communication;Communities;congenital cytomegalovirus;Custom;Cytomegalovirus;Data;data management;Data Science;Data Science Core;data sharing;Databases;Dedications;Disease;Ensure;Goals;Grant;Guidelines;Human Resources;Immune;Immune Evasion;Immunity;Immunologics;Individual;Infrastructure;Institution;knowledge integration;Lead;Leadership;Macaca mulatta;Maternal-Fetal Exchange;Medicine;meetings;Modeling;Monitor;multidisciplinary;Physicians;pre-clinical;prevent;Productivity;Program Research Project Grants;programs;Proteins;Publications;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;Strategic Planning;success;synergism;transmission process;United States National Institutes of Health;Universities;Vaccination;vaccine candidate;vaccine development;vaccine strategy;Veterinarians;Viral;virology


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PROJECT_TERMS: Acute;Address;Adherence;Age;Amniocentesis;Biological Models;Blood;Brain Injuries;Breeding;California;candidate identification;cell type;Cells;Child Health;clinical risk;Collaborations;Congenital Abnormality;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Data Analyses;data repository;Decidua;Development;Disease;effective intervention;Ensure;Experimental Designs;experimental study;Female;fetal;Fetal Tissues;flexibility;Gene Expression;Gene Expression Profile;Generations;Gestational Age;Goals;Human;Immune;Immune response;Immune Targeting;Immunity;Immunologics;In Vitro;in vivo;Infrastructure;Investigation;Macaca mulatta;male;maternal vaccination;Maternal-Fetal Exchange;Modeling;Monkeys;Mucous Membrane;multiple omics;Nature;new technology;nonhuman primate;novel;novel strategies;novel vaccines;novel virus;Oregon;Organoids;Partner in relationship;pathogen;Pathogenesis;Phenotype;Placenta;Play;Pre-Clinical Model;Predisposition;Pregnancy;prevent;Prevention;primary endpoint;Primates;Procedures;programs;Proteomics;Protocols documentation;Research;Resolution;Resources;response;Rhesus;Risk;Role;Sampling;secondary endpoint;Site;Structure;Technology;therapeutic target;therapy development;Time;Tissue Donors;Tissue Harvesting;tissue processing;Tissue Sample;Tissues;tool;transcriptomics;Translating;Translations;transmission process;trophoblast;Tropism;ultrasound;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;Vaccines;Vertebral column;Vertical Transmission;Viral;Viral Pathogenesis;viral transmission;virology;Virus

PROJECT_TITLE: Model Systems Core (MODS Core)


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

PI_NAMEs: MALOULI, DANIEL  (contact)

PROJECT_TERMS: Amniotic Fluid;Animal Experiments;Animals;Area;Bacterial Artificial Chromosomes;Biological Assay;Biological Models;Blood;Body Fluids;Cell Line;Clinical Research;co-infection;Collaborations;collaborative environment;Communication;Complex;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Data Analyses;Data Science Core;design;design and construction;Disease;DNA;Engineering;Ensure;Escherichia coli;Event;Evolution;experience;experimental study;Generations;Genes;genome integrity;Genomics;Glycoproteins;Goals;Growth;Human;Immune;Immune system;Immunity;Immunocompromised Host;Immunologics;In Vitro;in vivo;Infection;Intervention;Leadership;Licensing;Location;Macaca mulatta;Measurement;Measures;medical schools;member;Molecular Virology;Monitor;Morbidity - disease rate;mortality;mutant;Mutation;neonate;next generation sequencing;Open Reading Frames;Play;Population;Population Analysis;Population Heterogeneity;pressure;prevent;Primary Infection;Procedures;Process;Production;programs;prophylactic;Publications;Publishing;Quality Control;Recombinants;reconstitution;Research;Research Personnel;research study;Rhesus;Role;Sampling;Scientist;Services;Single Nucleotide Polymorphism;Standardization;Statistical Data Interpretation;success;Techniques;Therapeutic;tissue culture;tissue processing;Tissue Sample;Tissues;Transgenes;transmission process;Transplant Recipients;Vaccines;Viral;Viral Genome;Viremia;virology;Virus;Work

PROJECT_TITLE: Virology Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related

PI_NAMEs: CHAN, CLIBURN C (contact)

PROJECT_TERMS: Address;Amniotic Fluid;Antibodies;Antigen Receptors;Antigen-Antibody Complex;Applied Research;Autopsy;Bayesian Modeling;Binding;Biological Assay;Biological Markers;Biological Models;Biology;Body System;Categories;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Assay;Complex;Computational Biology;computing resources;congenital cytomegalovirus;Creativeness;Custom;cytokine;Cytomegalovirus;Data;Data Analyses;data ingestion;Data Science;Data Science Core;Data Set;data visualization;Databases;Dependence;design;dimension reduction;Disease;Engineering;Ensure;Epitopes;experience;Experimental Designs;experimental study;Flow Cytometry;Gene Expression Profile;Generations;Genes;high dimensionality;Immune;Immunocompetent;Immunofluorescence Microscopy;immunogenicity;Immunohistochemistry;Immunologic Factors;Immunologics;Immunology;Immunology procedure;interest;Knowledge;Link;Macaca mulatta;mathematical model;Metadata;Methods;Modeling;multiplex assay;mutant;nonhuman primate;novel;Outcome;Outcome Measure;Passive Immunization;Pattern;Plasma;prevent;primary outcome;Process;programs;Proteomics;Protocols documentation;Quality Control;Reproducibility;Research;Research Personnel;Resources;Saliva;saliva sample;Sample Size;single cell analysis;single-cell RNA sequencing;Stains;Statistical Data Interpretation;Statistical Models;statistics;Structure;T-Cell Depletion;T-cell receptor repertoire;Testing;Time;Tissues;tool;transcriptomics;transmission blocking;transmission process;Urine;vaccine efficacy;vaccine immunogenicity;Vaccines;vaccinology;Variant;Viral;Viral Load result;viral transmission;Viral Vaccines;virology;Virus;Virus Shedding;Visualization;Work

PROJECT_TITLE: Immune Data Science Core (IDS Core)


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: KAUR, AMITINDER  (contact)

PROJECT_TERMS: Address;adverse pregnancy outcome;Age;Amniotic Fluid;Animals;Bioinformatics;Blood;Breeding;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Assay;Cellular Immunity;Conceptions;congenital cytomegalovirus;CXCR3 gene;Cytomegalovirus;Cytomegalovirus Vaccines;cytotoxic;Data Analyses;Decidua;Disease;DNA;Enrollment;experimental study;Female;fetal;First Pregnancy Trimester;Frequencies;Immune;Immune response;Immunity;Immunocompetent;immunogenicity;Immunohistochemistry;Immunologics;immunopathology;Infection;Infectious Pregnancy Complications;Inflammation;Inflammatory;Innate Immune Response;Knowledge;Leukocytes;Listeria;Lymphocyte;Lymphocyte Depletion;Macaca mulatta;Maternal-Fetal Exchange;Modeling;Monitor;monocyte;mouse model;Natural Killer Cells;Neurologic;neutrophil;Newborn Infant;nonhuman primate;Organoids;Outcome;Partner in relationship;Pathogenesis;Placenta;Pregnancy;pregnant;prevent;Prevention;protective effect;Proteomics;recruit;Regimen;response;Role;Second Pregnancy Trimester;Sensorineural Hearing Loss;single-cell RNA sequencing;SIV;SIV Vaccines;success;T cell response;T-Lymphocyte;Testing;tissue archive;Tissues;trafficking;transcriptomics;transmission process;Vaccinated;vaccine candidate;vaccine evaluation;Vaccines;vector vaccine;Viral;virology;Virus;Virus Diseases

PROJECT_TITLE: Immune defense of cCMV at the maternal-fetal interface


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related

PI_NAMEs: FRUH, KLAUS J (contact)

PROJECT_TERMS: Affect;Animals;Antibody Response;Attenuated;Biological Models;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;chemokine;Complex;Congenital Abnormality;congenital cytomegalovirus;congenital infection;Control Groups;CXC Chemokines;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Data Science Core;Defect;Disease;experimental study;Family;Family member;Fetus;Glycoproteins;Goals;health goals;Homologous Gene;Human;IL8 gene;IL8RA gene;IL8RB gene;Immune;Immunity;Immunization;Immunize;Immunocompetent;immunogenic;Immunoglobulin G;Immunohistochemistry;Immunologics;immunoregulation;In Vitro;in vivo;in vivo monitoring;Infection;Innate Immune Response;innovation;Intravenous;Licensing;Macaca mulatta;mature animal;Measurement;Mediating;member;migration;Natural Killer Cells;Neighborhoods;neutrophil;novel;Open Reading Frames;Organoids;Placenta;Plasma;Play;prevent;Prevention;Primary Infection;Primates;Protein Family;Proteins;Proteomics;Public Health;Recombinants;Reporting;Rhesus;Role;single cell analysis;Statistical Data Interpretation;T cell response;T-Cell Depletion;T-Lymphocyte;Tissues;Transcript;transcriptomics;transmission process;vaccine development;Vaccines;Viral;Viral Physiology;Viremia;virology;Virus;Virus Diseases

PROJECT_TITLE: The role of viral chemokines for CMV dissemination and congenital infection


PROJECT_TERMS: Active Immunization;adaptive immunity;Affect;Antibodies;Antibody Response;Antigen Receptors;Antigens;Binding;Blood;Brain Injuries;CD4 Positive T Lymphocytes;Clinical Trials;CMV glycoprotein B;cohort;Congenital Abnormality;congenital cytomegalovirus;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data Analyses;data modeling;Development;Disease;Effectiveness;efficacy evaluation;Engineering;experience;Fc Receptor;Fetal Diseases;fetal loss;Globulins;Glycoproteins;Goals;high risk;Human;Immune Evasion;Immune response;Immunity;Immunization;Immunocompetent;immunogenicity;Immunoglobulin G;Immunologic Factors;Immunologic Receptors;Immunologics;Impairment;improved;in utero;In Vitro;in vivo;infant infection;Infection;Interruption;Length;Macaca mulatta;Maternal-Fetal Exchange;Measures;Mediating;Messenger RNA;Modeling;Monkeys;mRNA lipid nano particle vaccine;Natural Immunity;Neurologic;Newborn Infant;nonhuman primate;novel;passive antibodies;Passive Immunization;Placenta;Plasma Enhancement;pre-clinical assessment;preclinical evaluation;Pregnancy;pregnant;Prevalence;prevent;Prevention;protective effect;rational design;receptor;receptor binding;receptor function;Receptor Inhibition;response;Rhesus;Risk;Role;seropositive;T cell response;T-Cell Depletion;Testing;Time;transmission process;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine strategy;Vaccines;Variant;Vertical Disease Transmission;Viral;Viral Interference;Viremia;virology;Virus;Virus Receptors;Woman;Work

PROJECT_TITLE: Efficacy of CMV vFcR vaccines to prevent congenital CMV transmission


ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative Overall Component Health is a foundational source of wellbeing for people of all ages, and readily affected by our lifestyle decisions, behavioral interactions with the health care system, responses to adverse health events, and socioeconomic status. Our Center will use statistically-powered clinical trials to evaluate mechanisms of behavior change and test promising interventions, with the goal of improving population health. We will move promising interventions through the NIH Stage Model, with a primary focus on efficacy (Stage 2-3) and effectiveness (Stage 4) testing.

PI_NAMEs: ALSAN, MARCELLA ;DOYLE, JOSEPH J (contact)

PROJECT_TERMS: Affect;Age;Aging;Alcohols;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral Mechanisms;Behavioral Sciences;Categories;Clinic;Clinical Trials;Collaborations;Communities;Community Health;Conduct Clinical Trials;cost effective;Decision Making;Development;diet and exercise;Disparity;Disparity population;disparity reduction;Effectiveness;efficacy testing;Elements;Event;Exercise;exercise regimen;experimental study;Foundations;frontier;Goals;Health;health care delivery;health care disparity;health outcome disparity;Healthcare;Healthcare Systems;implementation research;improved;Incentives;Infrastructure;innovation;Insurance Carriers;Integrated Delivery of Health Care;Intervention;intervention delivery;intervention refinement;Intervention Trial;Joints;Leadership;Learning;Life;Life Style;Modeling;Opioid;Outcome;Pennsylvania;Personal Satisfaction;Persons;Population;population health;programs;Provider;Race;Recording of previous events;Reporting;Research;Research Activity;response;Running;Sample Size;Scientist;Site;smoking cessation;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;Subgroup;success;Testing;therapy development;Tobacco use;Translational Research;Treatment Efficacy;United States National Institutes of Health;Vaccination;vaccine acceptance;Vulnerable Populations;Work

PROJECT_TITLE: NBER Roybal Center for Behavior Change in Health


NIH_SPENDING_CATS: Aging;Behavioral and Social Science

PHR: OTHER PROJECT INFORMATION – Project Narrative Administrative Core Health is a foundational source of wellbeing for people of all ages. The Administrative Core will provide the infrastructure and critical operational support that allows the NBER Roybal Center to develop and test interventions that address real-world problems in ways that directly and cost-effectively improve population health.

PI_NAMEs: DOYLE, JOSEPH J (contact)

PROJECT_TERMS: Address;Advisory Committees;Age;Attention;Basic Science;behavior change;Behavior Therapy;Behavioral;Budgets;Clinic;Clinical Trials;Collaborations;Communication;Communities;cost;Data;data resource;Development;Discipline;Funding;Future;Goals;Grant;Health;improved;Infrastructure;innovation;Intervention;Joints;Leadership;Measures;meetings;Modeling;Monitoring Clinical Trials;Outcome;Output;outreach;Peer Review;Personal Satisfaction;Personnel Management;Persons;Phase;population health;Principal Investigator;Process;programs;prospective;Publications;Recommendation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Role;Safety;Scientist;Source;Strategic vision;Subgroup;success;Testing;Travel;trial planning;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Prevention

PHR: OTHER PROJECT INFORMATION – Project Narrative Behavioral Intervention Development Core Health is a foundational source of wellbeing for people of all ages, and readily affected by our lifestyle decisions, behavioral interactions with the health care system, and responses to adverse health events when they inevitably occur. In the BID core, we will use statistically-powered clinical trials to evaluate mechanisms of behavior change and test promising interventions, with the goal of improving population health.

PROJECT_TERMS: Affect;Age;Basic Science;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;Behavioral Mechanisms;Categories;Classification;Clinic;Clinical Trials;Collaborations;Communities;community engagement;Community Health;Data Collection;Decision Making;Dissemination and Implementation;Effectiveness;efficacy testing;Event;experimental study;Goals;Health;Health behavior;health care delivery;Health Promotion;Healthcare;Healthcare Systems;implementation research;improved;Incentives;Infrastructure;innovation;Insurance Carriers;Intervention;Intervention Studies;Life Style;Mission;Modeling;Outcome;Patients;Personal Satisfaction;Persons;population health;Provider;provider networks;Public Health;Recording of previous events;Research;Research Personnel;response;Site;Source;Testing;therapy development;Treatment Efficacy;United States National Institutes of Health


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Drug Abuse (NIDA only);Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Opioid use increases the levels of phosphorylated tau protein in the brain, which is a classical marker of tauopa- thy neurodegenerative diseases, yet opioid use is not known to produce classical tau-related neurodegeneration pathology. Therefore, it is not clear if opioid-induced changes in tau are a byproduct of opioid use that has no independent effect on neurobehavioral function or if these changes in tau contribute to the effect of opioids on neural function and opioid consumption-related behaviors. This high-risk, high-reward project tests the hypothe- sis that opioids increase tau expression, phosphorylation, and aggregation in the prefrontal cortex leading to synaptic dysfunction and elevated oxycodone consumption.

PI_NAMEs: ATWOOD, BRADY  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;adeno-associated viral vector;Adult women;Affect;Age;Alzheimer's Disease;Alzheimer's disease risk;Analgesics;Anterior;Autopsy;Behavior;Behavior assessment;behavioral response;Biochemical;Biological;Biology;Brain;brain health;Brain region;brain tissue;Chronic;Clinical Pathology;Clinical Research;Consumption;COVID-19 pandemic;Curiosities;Data;design;Development;Disease;Dose;drinking;Education;Electrophysiology (science);Epidemic;Formulation;Foundations;Frontotemporal Dementia;Functional disorder;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Health;Health Services Accessibility;high reward;high risk;hyperphosphorylated tau;Immunohistochemistry;Individual;Injections;interdisciplinary approach;Knock-out;Knockout Mice;Lifestyle-related condition;Link;male;Medial;Mediating;Mediator;Microglia;mouse model;Mus;Nerve Degeneration;neurobehavioral;Neurobiology;Neurodegenerative Disorders;neuroinflammation;Neurophysiology - biologic function;neurotransmission;novel therapeutics;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use disorder;Oral;overdose death;overexpression;Oxycodone;Pain;Pain management;patch clamp;Pathology;Persons;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;Policies;preclinical study;Predisposing Factor;preference;Prefrontal Cortex;Process;Proteins;Public Health;Regimen;Research;Rewards;Role;Saline;Slice;success;Synapses;synaptic function;Synaptic Transmission;tau aggregation;tau expression;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;transmission process;treatment effect;vector;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Functional consequences of the interactions between tau protein and opioids

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE This Northwell Roybal Center for Personalized Trials: Physical Activity Promotion for Persons Giving Care or Living with AD/ADRD aims to generate behavioral intervention development research for enhancing physical activity among individuals with AD/ADRD and the people who care for them. The Northwell Roybal Center will execute this mission through the Administrative Core, which will develop and provide the strategic vision, leadership, and full range of expertise needed for the success of this Roybal Center, and the Behavioral Intervention Development Core, which will identify and supervise the conduct of innovative clinical trials informed by the NIH Stage Model and the Roybal Center Themes.

PI_NAMEs: DAVIDSON, KARINA W. (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Alzheimer's disease related dementia;Award;Basic Science;behavior change;behavior test;Behavior Therapy;Behavioral Mechanisms;Behavioral trial;care providers;Caregivers;Caring;clinical center;Clinical Trials;Cognitive;Collaborations;Communities;Creativeness;Data;design;Development;Effectiveness;Eligibility Determination;Ensure;Evaluation;evidence base;Feedback;Fostering;Funding;Future;Goals;Habits;Home Care Agencies;Home Health Aides;Hour;Hybrids;improved;Individual;Infrastructure;innovation;interest;Intervention;intervention program;Intervention Studies;Intervention Trial;Leadership;Maintenance;Measures;Mission;Modeling;Monitor;National Institute on Aging;New York;Nursing Services;older adult;Pathway interactions;Persons;Physical activity;Productivity;Program Development;programs;Regimen;Research;research and development;Research Personnel;Research Support;Resources;Safety;Scientist;sedentary;social interventions;Strategic vision;success;Techniques;Technology;Testing;theories;Theory of Change;therapy development;Time;Translational trial;trial design;United States National Institutes of Health;virtual intervention;Visiting Nurse;Walking;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Physical Activity;Prevention

PHR: See attachment in Overall Component, Other Project Information, Narrative

PROJECT_TERMS: Advisory Committees;Agreement;Alzheimer's disease related dementia;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral trial;care providers;caregiver interventions;Caregivers;Caring;Characteristics;clinical center;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communities;Data;data exchange;Dementia;demographics;Deposition;Development;Effectiveness of Interventions;Ensure;Evaluation;Expert Systems;Feedback;Future;Goals;Grant;Health;human subject;improved;Individual;Infrastructure;Institutional Review Boards;interest;Intervention;intervention program;Intervention Studies;Intervention Trial;Leadership;Maintenance;Measures;meetings;Mission;Modeling;Monitor;National Institute on Aging;Office of Administrative Management;open data;Operations Research;Participant;patient population;Patients;Persons;Physical activity;Process;Productivity;programs;Progress Reports;Quality of life;Regimen;Regulation;repository;Research Activity;research and development;Resources;Safety;Scientist;Skilled Nursing Facilities;social interventions;Strategic vision;success;System;therapy development;Translational trial;Travel;Underrepresented Populations;United States National Institutes of Health;Vision;Work;Writing

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

PI_NAMEs: BUTLER, MARK  (contact)

PROJECT_TERMS: Alzheimer's disease related dementia;Award;Basic Science;behavior change;behavior test;Behavior Therapy;Behavioral Mechanisms;Behavioral trial;caregiver interventions;Caregivers;Caring;Clinical Trials;Cognitive;Communities;Consultations;Creativeness;Data;demographics;Development;Eligibility Determination;Ensure;Evaluation;evidence base;exercise intervention;experience;Fostering;Funding;Future;Goals;Habits;Hour;Infrastructure;innovation;Institution;Internet;Intervention;Intervention Studies;Intervention Trial;Lead;Maintenance;Measurement;Measures;Methodology;Methods;Mission;Modeling;Monitor;open data;Pathway interactions;Peer Review;Persons;Physical activity;physical model;Process;programs;Progress Reports;Protocols documentation;Regimen;Reporter;Reporting;Request for Applications;Research;research and development;Research Personnel;Research Support;Resources;Review Committee;Safety;Science;Science Policy;Scientist;sedentary;social interventions;Structure;Techniques;Testing;theories;Theory of Change;therapy development;Time;timeline;Translating;Translational trial;United States National Institutes of Health;Vision;Walking;Work

PROJECT_TITLE: BID Core with P1 and P2


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: WILMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA WILMINGTON

ORG_STATE: NC

PHR: Project Narrative This project seeks to develop a fundamental understanding of interactions of β-peptides with membranes, to understand folding of β-barrel proteins, and to enable design of membrane proteins that can be assembled from modular elements. In the long term, this would enable us to design proteins with modified functionalities that can be added from the outside and assemble in the cell membrane. Those functions can improve uptake of drugs, antibiotics or nutrients (metabolites) at the cellular level, with vast applications to human health.

PI_NAMEs: ALMEIDA, PAULO F (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;alpha helix;Antibiotics;aqueous;Attention;beta barrel;Binding;Binding Sites;Biochemistry;Biological Models;biophysical techniques;carboxyfluorescein;Cell membrane;Cellular Membrane;Chloroplasts;Circular Dichroism;Coupled;Data;Dependence;design;Detergents;Dextrans;Drug Delivery Systems;Dyes;Elements;Encapsulated;Engineering;Equilibrium;experience;Exposure to;Fluorescence;Foundations;Gram-Negative Bacteria;Grant;guanidinium;Health;Human;Hydrophobicity;improved;Ions;Kinetics;Lateral;Learning;Length;Lipid Bilayers;Lipids;Measures;Membrane;Membrane Lipids;Membrane Proteins;Metals;Methods;Mitochondria;Modeling;Molecular;monomer;Nature;Nutrient;peptide structure;Peptides;Pharmaceutical Preparations;Phase;Physical Chemistry;polypeptide;Process;protein aggregation;protein aminoacid sequence;Protein Engineering;Proteins;Reaction;Role;Shapes;small molecule;Structure;Students;Surface;Techniques;Testing;theories;Thermodynamics;undergraduate student;United States National Institutes of Health;uptake;Urea;Variant;Vesicle;Water

PROJECT_TITLE: Interaction of β-Hairpin Peptides with Membranes

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Infectious Diseases

ORG_CITY: VALPARAISO

ORG_NAME: VALPARAISO UNIVERSITY

ORG_STATE: IN

PHR: Defining the gut environmental factors responsible for the shift of C. albicans from harmless to virulent and how it subverts the gut clearance defense mechanism (aka fluid secretion) will have important impact on public health as invasive candidiasis originates from the gut. These two aspects have been overlooked, and this application proposed to shed some light on those two mechanisms and provide ground work to better prevent and treat invasive candidiasis

PI_NAMEs: BOUYER, PATRICE GUY (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Bacteria;Biochemical;Biotinylation;Blood;Brightfield Microscopy;Caco-2 Cells;Candida albicans;Candidiasis;Cells;Chlorides;Colon;colonic crypt;combat;Critical Illness;crypt cell;Cues;Defense Mechanisms;design;Disease;Endocytosis;Endosomes;Environmental Risk Factor;Epithelial Cells;Epithelium;Estradiol;Estrogens;Event;fighting;Fluids and Secretions;Fluorescence;Fluorescence Microscopy;fungus;gastrointestinal epithelium;global health;Goals;Health;Hormones;Hospitalization;Host Defense Mechanism;Human;Immunoprecipitation;improved;Infection;innovation;insight;intestinal barrier;intestinal epithelium;Intestines;Invaded;Knowledge;Laboratories;Link;Liquid substance;Lysosomes;Maps;MDCK cell;Measures;Mediating;Medical Care Costs;Membrane;Membrane Transport Proteins;Microscopy;Modeling;Monitor;Morphology;Mycoses;Nosocomial Infections;opportunistic pathogen;Organ;Outcome;Outpatients;pathogen;pathogenic bacteria;pathogenic fungus;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;prevent;Probability;Process;Protein Kinase C;Protein Kinase C Inhibitor;Proteins;Public Health;Recycling;Regulation;Reporting;Research;Resistance;Role;Sepsis;Signal Pathway;Signal Transduction;skills;Skin;Solid;Stream;Surface;symporter;Techniques;Testing;Time;Toxin;Ubiquitin;Ubiquitination;undergraduate student;Vagina;Vesicle;Virulence;Virulent;Visit;Western Blotting;Work;Yeasts

PROJECT_TITLE: Gut clearance regulation and its subversion by Candida albicans

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Estrogen;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative This exploratory and developmental project proposes an early phase clinical research to elucidate molecular targets of interventions aimed at preventing tamoxifen resistance and cancer metastasis associated with long- term tamoxifen treatment of breast cancer patients.

PI_NAMEs: SHARMA, JYOTIKA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;advanced breast cancer;Adverse effects;antimicrobial;Blood;Blood specimen;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Breast Cancer therapy;Breast Cancer Treatment;Bypass;cancer cell;Cancer Center;cancer recurrence;Cancer Relapse;cancer therapy;Cell Physiology;Cell Survival;cell type;Cells;Chronic Granulomatous Disease;Clinical;Clinical Data;Clinical Research;cohort;Collaborations;Communicable Diseases;comorbidity;Country;Data;design;Development;Disease;Distant;DNA;Endometrial Carcinoma;ESR1 gene;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;Exhibits;experience;extracellular;FDA approved;Future;Genetic Transcription;hormone therapy;Host Defense;Human;Immune;Immune response;immunopathology;improved;In Vitro;Inflammatory;insight;Intervention;Invaded;Link;Lymphocyte;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Microbe;Molecular;Molecular Target;Neoplasm Metastasis;neutrophil;novel;novel strategies;Organ;Outcome;pathogen;Pathologic;Pathology;Pathway interactions;Patient Recruitments;Patients;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;Population;Postmenopause;Premenopause;prevent;programs;Proteins;Reactive Oxygen Species;Recurrent disease;Reporting;Resistance;Resistance development;response;Risk Reduction;Role;Selective Estrogen Receptor Modulators;Side;side effect;Signal Transduction;Tamoxifen;Testing;Therapeutic;therapy resistant;Time;transcriptional reprogramming;transcriptomics;translational study;tumor;tumor progression;Woman;women's diagnosis

PROJECT_TITLE: Impact of tamoxifen treatment on neutrophils in breast cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: HIGHLAND HEIGHTS

ORG_NAME: NORTHERN KENTUCKY UNIVERSITY

ORG_STATE: KY

PHR: Project Narrative The objective of the proposed research is relevant to public health because S-adenosylmethionine (AdoMet) synthetase genes and AdoMet have been implicated in multiple cancer types, but the mechanism of action is not well understood because both increases and decreases in expression are associated with cancers. Our group has conducted studies on the AdoMet synthetase genes, SAM1 and SAM2, in S. cerevisiae and determined the opposite nature of impacts of deletion of these paralogous genes on genome stability and other cellular pathways. In addition to advancing the field towards a more complete mechanistic understanding of regulation of AdoMet and a detailed characterization of the impacts of mutations; including effects on the methyl cycle and the individual steps in genome stability changes, this multi-disciplinary project meets the stated objectives of the AREA program by offering undergraduate students hands-on training in classical genetics and modern molecular techniques and strengthens the research environment at Northern Kentucky University.

PI_NAMEs: STROME, ERIN D (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Alkylation;Anabolism;Binding;Biological Assay;Biomedical Research;cancer therapy;cancer type;Cell Physiology;Cells;Chromosomal Stability;Chromosome Mapping;Cytoplasm;D Cells;Data;defined contribution;Development;differential expression;Disease;Educational process of instructing;Environment;Event;Excision;Folic Acid;Funding;Gene Conversion;Gene Deletion;Gene Dosage;Gene Mutation;Genes;Genetic;Genetic Recombination;Genome;Genome Stability;Genomic Instability;Goals;Grant;Homologous Gene;Human;improved;Individual;insight;Institution;interest;Investigation;Kentucky;Ligase;Link;Malignant Neoplasms;methionine adenosyltransferase;methyl group;Methylation;Methyltransferase;Micro Array Data;Modeling;Modernization;Molecular;Molecular Biology;multidisciplinary;mutant;Mutation;Nature;nucleotide metabolism;Nucleotides;paralogous gene;Pathway interactions;Phenotype;Play;Point Mutation;Polyamines;Process;Production;programs;Promoter Regions;protective effect;Proteins;Proteome;Proteomics;Public Health;Regulation;Research;Ribonucleotide Reductase;Role;Saccharomyces cerevisiae;scientific literacy;Scientist;System;Techniques;Testing;Training;transcriptome sequencing;treatment planning;undergraduate student;Universities;Yeasts

PROJECT_TITLE: Characterization of SAM gene mutation impacts on cellular processes and genome instability


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The goal of our proposed Roybal Center is to speed up the pace and increase the impact of scientific discoveries about how to change health behaviors to prevent premature aging. To do this, we focus on three innovative strategies: design thinking to incorporate the experiences of older adults; online platforms that help us conduct large-scale studies easily; and dynamic adaptation, which allows us quickly learn how different interventions work for different populations. With these strategies, we will design and conduct studies ranging from small pilots to ensure our interventions can work up to larger-scale studies with companies and health care organizations that show how interventions do work in real-world settings.

PI_NAMEs: BUTTENHEIM, ALISON MEREDITH;VOLPP, KEVIN G (contact)

PROJECT_TERMS: Acceleration;Acute;American;Arts;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;behavioral health;Behavioral Mechanisms;Clinical Sciences;Collaborations;community setting;Complex;cost effective;Country;Data;design;Diagnosis;dietary;digital platform;Discipline;Dissemination and Implementation;Drops;Economic Factors;effective intervention;Effectiveness;effectiveness trial;efficacious intervention;Ensure;Evaluation;experience;Faculty;field study;frontier;Goals;Grant;Health;Health behavior;Health behavior change;health care service organization;Health system;Healthcare;Healthcare Systems;Human;improved;Individual;Infrastructure;innovation;insight;Institution;interdisciplinary collaboration;Intervention;Intervention Trial;Leadership;Learning;Life Expectancy;medical schools;Modeling;Motivation;Myopia;Obesity;older adult;peer;Pennsylvania;Population;population health;Premature aging syndrome;Premature Mortality;prevent;Prevention;Private Sector;Probability;Psychological Factors;Public Sector;Publishing;Research;Research Activity;Research Personnel;research study;Research Support;Resource Allocation;Resources;School Nursing;Schools;Science;Scientist;Services;Site;social;Social Sciences;Speed;success;Technology;technology platform;Testing;therapy development;Thinking;Time;Translating;Translations;United States;United States National Institutes of Health;Universities;voltage;Work

PROJECT_TITLE: The Penn Roybal Center on Behavioral Economics and Health: Solving for Scale and Impact with Design Thinking, Digital Platforms, and Dynamic Adaptation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: VOLPP, KEVIN G (contact)

PROJECT_TERMS: acceptability and feasibility;Advisory Committees;American;American Heart Association;Behavior;behavior change;Behavior Therapy;behavioral economics;behavioral health;Behavioral Mechanisms;behavioral study;Blue Cross;Collaborations;Communities;design;Development;digital platform;Dissemination and Implementation;Drops;editorial;Effectiveness;effectiveness study;Engineering;Ensure;experience;Faculty;field study;Fostering;Future;Generations;Goals;Health;Health behavior;Health behavior change;health care service organization;Health Insurance;Health system;Healthcare;improved;Incentives;Individual;Infrastructure;innovation;insight;Institution;Intervention;Journals;Leadership;Learning;Medicine;member;Modeling;Monitor;multidisciplinary;older adult;Participant;Pathway interactions;Pennsylvania;Pilot Projects;Population;Population Heterogeneity;Premature aging syndrome;prevent;Private Sector;Progress Reports;Public Policy;Public Sector;Reporting;Research;Research Personnel;research to practice;Role;Science;Secure;service organization;Services;Speed;symposium;Technology;Testing;therapy development;Thinking;Training Support;Translating;translational potential;Translational Research;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;user centered design;voltage;Weight;Work


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Nutrition;Prevention

PI_NAMEs: BUTTENHEIM, ALISON MEREDITH (contact)

PROJECT_TERMS: Address;Adherence;Advisory Committees;Aging;American;Area;Artificial Intelligence;Behavior;behavior change;Behavior Therapy;behavioral economics;behavioral health;Behavioral Mechanisms;blood pressure control;Center for Translational Science Activities;Collaborations;design;Diabetes Mellitus;Dietary Fiber;digital platform;Effectiveness;Effectiveness of Interventions;effectiveness testing;efficacy testing;Ensure;experience;Faculty;feasibility testing;financial incentive;Funding;Goals;Grain;Health;Health behavior;Health behavior change;health care service organization;Healthy Eating;human centered design;Hyperaldosteronism;improved;Individual;innovation;Institution;Intervention;Intervention Studies;Learning;Maintenance;Marketing;Mentorship;middle age;Mission;Modeling;modifiable risk;Morbidity - disease rate;mortality;older adult;Patients;Pilot Projects;pilot test;Population;Population Heterogeneity;Prediabetes syndrome;Premature aging syndrome;prevent;Privatization;Process;Program Description;Provider;Research;Research Personnel;Resources;screening;Source;Speed;success;Technology;technology platform;Testing;therapy development;Thinking;Training;Translating;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: BID Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Hematology;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: BELLINGHAM

ORG_NAME: WESTERN WASHINGTON UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Hemophilia A is caused by the disruption of the gene encoding blood coagulation factor VIII and is the most common form of hemophilia, affecting 1 in 5,000 males worldwide. The most significant complication in the management of hemophilia A is the development of an inhibitory immune response to therapeutically infused factor VIII. Studying the blood coagulation mechanism of, and immune response to, factor VIII with a combination of structural and biochemical techniques can lead to improved therapies for hemophilia A patients.

PI_NAMEs: SPIEGEL, PAUL CLINTON (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Affect;Antibodies;antibody inhibitor;arm;Autoimmune Diseases;B-domain-deleted factor VIII;Binding;Biochemical;Biological Assay;Biomedical Engineering;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;C-terminal;C2 Domain;Calorimetry;Charge;Circulation;Clinical;Coagulation Process;cofactor;Complex;Complication;Cryoelectron Microscopy;DAG/PE-Binding Domain;Data;Development;Docking;effective therapy;Engineering;Epitopes;Factor IXa;factor IXa-factor VIIIa;Factor VIII;Factor VIIIa;Factor X;Genes;Genetic;Hemophilia A;Hemophilia B;Immune response;immunogenic;improved;Individual;Infusion procedures;Life Cycle Stages;Link;Lipids;male;Measures;Membrane;Membrane Lipids;membrane model;Modeling;Molecular;Molecular Conformation;mouse model;Mutagenesis;nanodisk;Nature;NMR Spectroscopy;novel therapeutics;Pathogenicity;Pathologic;Patients;Progress Reports;protein complex;Proteins;Recombinant Proteins;Regulation;Replacement Therapy;Resolution;Roentgen Rays;Serine Protease;Structure;Surface;Techniques;Testing;Therapeutic;therapeutic protein;Thermodynamics;Titrations;Variant

PROJECT_TITLE: Structural and Biochemical Studies of Blood Coagulation Factor VIII to Overcome the Immune Response

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_DEPT: BIOCHEMISTRY

PHR: The proposed studies address the structural underpinnings of the activation of prothrombin by prothrombinase leading to the blood coagulation response. Progress in this area will impact basic knowledge of the pathophysiology of blood coagulation and its therapeutic control.

PI_NAMEs: DI CERA, ENRICO  (contact)

PROJECT_TERMS: activated Protein C;Active Sites;Address;Architecture;Area;Binding;Biological;Blood;Blood coagulation;Blood Coagulation Factor;Coagulation Process;Complement;Complex;Cryoelectron Microscopy;Data;Development;Environment;Enzyme Precursors;Enzymes;Factor V;Factor Va;Factor Xa;Functional disorder;Hemostatic function;in vivo;innovation;Investigation;Kinetics;Knowledge;meizothrombin;Membrane;Molecular;Molecular Conformation;nanodisk;Nature;Pathway interactions;Physiological;Positioning Attribute;prethrombins;Proteins;Prothrombin;prothrombinase complex;Publishing;Reaction;Research;Resolution;response;RNA Splicing;scaffold;Scheme;Site;Solid;Structure;success;Testing;Therapeutic;Thrombin;Thromboplastin;Thrombosis;Time;translational applications;translational potential;Trypsin;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Structural basis of prothrombin activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LANCASTER

ORG_NAME: FRANKLIN AND MARSHALL COLLEGE

PHR: PROJECT NARRATIVE  The proposed research focuses on using infrared (IR) spectroscopy with vibrational reporters (nitriles and azides) to probe local structure and dynamics in two proteins (adenylate kinase [AK] and superfolder green fluorescent protein) and in RNA hairpins. Mutations in AK are associated with hemolytic anemia, reticular dysgenesis, and ciliary dyskinesia. RNA structure is complex and the information gained from this research has the potential to benefit future advances in RNA vaccines, CRISPR, and RNA interference therapies.

PI_NAMEs: BREWER, SCOTT H (contact);FENLON, EDWARD EMMETT

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: adenylate kinase;Austria;Azides;Buffers;Chemicals;Ciliary Motility Disorders;Collaborations;college;Complex;Coupled;Coupling;CRISPR interference;Crystallography;Data;Deoxyuridine;Development;dimer;Effectiveness;Electrostatics;Environment;experimental study;Fluorescence Resonance Energy Transfer;Frequencies;Future;Goals;Green Fluorescent Proteins;Health;Hemolytic Anemia;Hydration status;Hydrogen Bonding;Individual;infrared spectroscopy;Isotope Labeling;Kinetics;Measurement;Measures;Methodology;Methods;Molecular;monomer;Mutation;Nevada;Nitriles;nucleic acid structure;Nucleic Acids;Nucleosides;Nucleotides;Pathway interactions;Phenylalanine;Play;Protein Kinase;Proteins;Reporter;Research;reticular dysgenesis;RNA;RNA Interference Therapy;RNA vaccine;Roentgen Rays;Role;simulation;Site;Solvents;Specificity;Stretching;Structure;Students;System;Temperature;temporal measurement;two-dimensional;undergraduate research;undergraduate student;Universities;unnatural amino acids;Variant;X-Ray Crystallography

PROJECT_TITLE: Use of Vibrational Reporters to Measure Dynamics and Distances in RNA and Proteins

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Urologic Diseases

ORG_CITY: NEWPORT

ORG_NAME: SALVE REGINA UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Bacterial cells in the environment communicate through the language of molecular cues. Here, we propose to study how molecules derived from the bacterial cell wall regulate bacterial growth decisions using the paradigm of bacterial dormancy in a prototypic uropathogenic strain of Escherichia coli. This research will identify the pharmacophore of the cell wall signal, or cue, elucidate genes that enable the bacterial response to the signal, and identify bacterial protein targets that engage the signal to further understand the underlying mechanism of bacterial crosstalk. The work in this proposal will expose 6 to 10 undergraduate students to biomedically relevant research with significant impact in synthetic chemistry and bacterial genetics.

PI_NAMEs: MESCHWITZ, SUSAN  (contact)

PROJECT_TERMS: Acids;Active Learning;Affinity;alpha ketoglutarate;Amino Acids;Ampicillin;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Award;bacterial genetics;Bacterial Physiology;Bacterial Proteins;Binding;Binding Proteins;Biological;Cell Communication;cell growth;Cell Wall;Cells;Cellular biology;chemical synthesis;Chemicals;Chemistry;Clinical;Collaborations;Communication;Communities;Complex;Cues;design;Detection;Environment;Escherichia coli;Escherichia coli Infections;experience;experimental study;Faculty;Fluorescence Microscopy;Gene Expression;Genes;Genetic Screening;graduate student;Grant;Growth;homoserine lactone;Human;Immune;improved;In Vitro;in vitro Model;innovation;Institution;Interdisciplinary Study;Knowledge;Label;Laboratories;Language;Libraries;Ligands;Measures;Mentorship;Metabolic;Molecular;Molecular Biology;Monitor;mutant;Natural Products Chemistry;novel strategies;Ointments;pathogenic bacteria;Pathway interactions;peptide analog;Peptide Synthesis;Peptides;Peptidoglycan;Pharmacologic Substance;pharmacophore;Population;Probiotics;programs;Proliferating;Proteins;Proteomics;prototype;quorum sensing;reconstitution;Research;Research Methodology;response;Resuscitation;Rhode Island;Science;Signal Transduction;skills;small molecule;Staphylococcus aureus;stem;Stress;Students;Succinates;Synthesis Chemistry;Testing;Training;training opportunity;undergraduate student;Universities;Uropathogenic E. coli;Work

PROJECT_TITLE: Peptide cues in the environment regulate bacterial dormancy

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences

ORG_CITY: PROVO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative This study investigates how the redox state (and its alteration via environmental and genetic factors) during optic tectum (OT) development, the homolog to the mammalian superior colliculus (SC), affects OT neurogenesis and specification and modifies subsequent OT-driven behaviors. Accumulating evidence has implicated the SC in neurodevelopmental disorders, such as autism spectrum disorder (ASD), and in neurodegenerative disorders, such as Lewy body dementia, Parkinson disease, progressive supranuclear palsy etc. Very few studies have investigated the effects of redox state in OT circuitry, therefore, our study would fill an important gap in the current understanding. Additionally, since the SC is associated with ASD, and the environmental factor used here, valproic acid, is also correlated with higher ASD incidence, this study might shed light into the molecular and cellular underpinnings of ASD.

PI_NAMEs: SULI, ARMINDA  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Affect;Animal Behavior;Antioxidants;Attention;autism spectrum disorder;Behavior;behavior influence;behavioral phenotyping;behavioral response;Cell Compartmentation;cell growth regulation;Cell Nucleus;Cell Physiology;Cells;Cellular Morphology;Child;Cues;Cytoplasm;design;Development;Dose;Electrophysiology (science);Embryo;Environment;Environmental Risk Factor;Event;Exhibits;experimental study;Exposure to;follow-up;Generations;Genes;Genetic;Goals;Homologous Gene;Hydrogen Peroxide;Image;In Vitro;in vivo;Incidence;Involuntary Movements;Knowledge;Larva;Lewy Body Dementia;Light;Midbrain structure;migration;Mitochondria;Modality;model organism;Molecular;Movement;multimodality;Names;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurogenesis;neuron development;neuron loss;Neuronal Differentiation;Neurons;Nuclear;Output;oxidation;Oxidation-Reduction;Paper;Parkinson Disease;Pharmaceutical Preparations;Population;Post-Translational Protein Processing;prenatal exposure;Progressive Supranuclear Palsy;Proliferating;Reaction;Regulation;response;retinotectal;selective attention;sensory input;sensory integration;single-cell RNA sequencing;Specific qualifier value;Stimulus;Structure;superior colliculus Corpora quadrigemina;Techniques;Testing;theories;Time;Tissues;tool;transcription factor;Valproic Acid;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Determining how redox changes affect optic tectum circuitry development and behavior.

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Natural Products

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative Quaternary carbon centers are vital for the structural diversity of organic compounds, impacting the biological activity of natural products, pharmaceuticals, and materials. This proposal aims to develop oxidative conditions for the dearomatization of substituted phenols and achieve the total synthesis medicinally relevant natural products and drug candidates.

PI_NAMEs: YUAN, YU  (contact)

PROJECT_TITLE: Synthesis of Natural Products by Oxidative Dearomatization and Discovery of BRAT1 Degraders

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Diabetes;Dietary Supplements;Microbiome;Nutrition;Obesity

ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative: One’s diet and other factors influence the innate population of gut bacteria (the “microbiota”), which in turn helps shape physiology and health. Specific metabolites that are made by the microbiota are called xenometabolites, which can play communication and signaling roles in the host. Identifying the entire catalog of these molecules, understanding their trafficking and storage, and determining their specific roles is an emerging field of study. This proposal will characterize how unique microbe-derived fats are generated and will explore how these xenolipids regulate physiological systems important to physiology and metabolism.

PI_NAMEs: ADAMS, SEAN HARRISON (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acids;Acute;Address;Adipocytes;Adipose tissue;Age;Animal Model;Animals;Antiinflammatory Effect;Automobile Driving;Bacteria;bacterial community;Binding;Blood;carbene;Carbohydrates;Cataloging;Catalogs;Characteristics;Chemicals;ChIP-seq;Communication;Communities;Complex;cyclopropane;cyclopropane synthetase;Data;Diabetes Mellitus;Diet;Dietary Component;Dietary Factors;Disease;Disease remission;Disparate;DNA sequencing;Endocrine system;Etiology;Exercise;Fatty acid glycerol esters;Fatty Acids;Feces;Fiber;field study;fitness;functional outcomes;G-Protein-Coupled Receptors;Generations;Goals;gut bacteria;gut microbes;gut microbiota;Health;Health Status;Hepatocyte;Human;human model;Immune system;Inflammation;innovation;Intestines;Knowledge;Label;Lead;Libraries;Link;lipidome;Lipids;Literature;Macrophage;Metabolic;Metabolism;metabolome;metabolomics;Microbe;microbial;microbial community;microbiome;microbiota;Modification;Molecular;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Receptors;Nutraceutical;Obesity;Organoids;Outcome;Pathway interactions;Pattern;Peroxisome Proliferator-Activated Receptors;Persons;Phenotype;Phylogeny;Physiological;Physiology;Play;Population;PPAR alpha;PPAR delta;PPAR gamma;prebiotics;Probiotics;Production;Publishing;Rattus;Regulation;Reproducibility;Research;response;Role;Same-sex;Sampling;screening;Shapes;Signal Transduction;stem;Structure;System;Taxonomy;Technology;Testing;Time;Tissues;tool;trafficking;transcriptome sequencing;Unsaturated Fatty Acids

PROJECT_TITLE: Identification of human gut microbe-derived xenolipids: impact of fibers and host metabolic health

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative (Overall) The goal of the Arizona State University Roybal Center for Older Adults Living Alone with Cognitive Decline (ASU Roybal) is to develop infrastructure, facilitate the design and conduct of 12 clinical trials, and sustain the Center’s long-term impact. The interventions will be driven by mechanisms of behavior change and apply digital technologies to delay Alzheimer’s disease and related dementias. These interventions will empower this population and improve their quality of life. It will test innovative technology-enabled interventions in a growing but overlooked population—older adults living alone with cognitive decline.

PI_NAMEs: YU, FANG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adherence;Adverse event;Advisory Committees;Affect;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Applications Grants;Area;Arizona;Artificial Intelligence;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral trial;Biological;Clinical Trials;Cognition;Collaborations;Communities;Conduct Clinical Trials;cost of dementia;Data Analyses;Data Collection;Data Set;design;digital technology;empowerment;Exclusion;experience;functional status;Funding;Goals;Health Disparities Research;Hispanic Americans;Home;Impaired cognition;improved;Inflammation;Information Dissemination;Infrastructure;innovative technologies;Intervention;intervention delivery;intervention effect;Intervention Studies;Intervention Trial;Knowledge;Life;Life Style;lifestyle intervention;Mentors;mild cognitive impairment;Minority;Modeling;modifiable risk;older adult;Older Population;Outcome;Performance;Persons;Physical activity;Physical Function;physical inactivity;Population;prevent;Prevention;Process;Quality of life;Recommendation;recruit;Research;Research Personnel;Resources;Risk Factors;Senior Scientist;Social Processes;social stress;Social support;Stress;symposium;symptom science;Technology;technology intervention;Testing;therapy development;trial design;United States National Institutes of Health;Universities;uptake;wearable device;Well in self;Work

PROJECT_TITLE: Arizona State University Roybal Center for Older Adults Living Alone with Cognitive Decline: Technology-Enabled Behavioral and Lifestyle Change to Delay Alzheimer's Disease and Improve Quality of Life


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: ANDEL, ROSS  (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Applications Grants;Arizona;Artificial Intelligence;Attention;Award;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Clinical Trials;Cognitive;Collaborations;Common Data Element;Communication;Communities;Data;Data Analyses;data de-identification;data repository;design;Epidemiology;Evaluation;evidence base;Exclusion;experience;Failure;Fostering;Foundations;functional improvement;Gerontology;Goals;Health Disparities Research;health disparity;health inequalities;higher education;Hispanic Americans;Impaired cognition;improved;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Life;Life Style;Life Style Modification;lifestyle intervention;Minority;Modeling;Moods;older adult;operation;Patient Recruitments;Physical activity;Predisposition;prevent;Process;programs;Publications;Quality of life;recruit;Research Personnel;Resources;Scientist;secondary analysis;Strategic Planning;Strategic vision;success;symposium;symptom science;Symptoms;Technology;technology intervention;United States National Institutes of Health;Universities;uptake;Vision;wearable device

PROJECT_TITLE: ASU Roybal Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation

PROJECT_TERMS: Affect;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Arizona;Artificial Intelligence;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Biological;Caregivers;Caring;Clinical Trials;Clinical Trials Design;Cognition;Cognitive Therapy;Conduct Clinical Trials;Data Analyses;design;Development;digital technology;effectiveness testing;Emotional;empowerment;Ensure;Exclusion;exergame;Feedback;functional status;Goals;Grant;Guidelines;health disparity;Health Technology;Hispanic Americans;Human Subject Research;Impaired cognition;improved;Infrastructure;innovation;Institutional Review Boards;Intervention;Latino Population;Life;Life Style;lifestyle intervention;meetings;Methodology;mild cognitive impairment;Modeling;Modification;Monitor;new technology;older adult;Outcome;Patient Outcomes Assessments;Physical activity;Policies;Population;practical application;Predisposition;Process;Quality of life;recruit;Registries;Research;Research Personnel;Resources;Safety;Scientist;social;Social Processes;Technology;technology intervention;Testing;therapy development;timeline;Translating;trial design;United States National Institutes of Health;Universities;uptake;virtual coach;virtual intervention;virtual patient;wearable device;Work

PROJECT_TITLE: ASU Roybal Behavioral Intervention Development (BID) Core


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE (Overall): Dementia impacts both the person who carries the diagnoses and their care-partners. However, most interventions do not account for the interrelation among the dyad members when conducting behavioral research, with negative consequences for both the affected person and their care-partner. The MGH CONFIDE-ADRD will provide a research infrastructure with a novel experiential learning and team science approach to enhance dementia dyadic behavioral research to improve health and prevent negative individual and dyadic health outcomes.

PI_NAMEs: OKEREKE, OLIVIA IFEOMA;VRANCEANU, ANA-MARIA  (contact)

PROJECT_TERMS: Acceleration;Accounting;Active Learning;Address;Affect;Aging;Alzheimer's disease related dementia;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Research;Biometry;Capsicum;Caring;Centers for Disease Control and Prevention (U.S.);Child;Clinical;Clinical Research;cognitive function;Collaborations;collaboratory;Communities;community engaged research;community setting;Dedications;Dementia;dementia care;design;Development;Diagnosis;digital health;discounting;Educational workshop;Elderly;emotional functioning;Ensure;Exercise;experience;Family;Fostering;Foundations;Friends;Funding;Future;General Hospitals;Gerontology;Grant;Grant Review;hands-on learning;Health;health disparity;Health Status;Hospitals;improved;Individual;informal care;innovation;Institution;Interdisciplinary Study;Interpersonal Relations;Intervention;intervention mapping;Intervention Studies;Justice;Knowledge;Lead;Leadership;learning strategy;Link;Lived experience;Massachusetts;Measurement;medical schools;Medicine;member;Mentors;Minority;Modeling;next generation;novel;Outcome;Outcomes Research;Palliative Care;Patient Care;Patients;Persons;Physical Function;Policies;prevent;preventive intervention;Primary Prevention;Process;programs;Psychiatrist;Psychiatry;Psychologist;Public Health Schools;Racial Equity;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Priority;research to practice;Resources;Role;routine care;scale up;Science;Scientist;Secondary Prevention;Severities;skills;Societies;Spouses;statistics;success;Terminal Disease;tertiary prevention;Testing;theories;therapy design;therapy development;Translational Research;Translations;United States National Institutes of Health;uptake;Writing

PROJECT_TITLE: MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: VRANCEANU, ANA-MARIA  (contact)

PROJECT_TERMS: Acceleration;Active Learning;advanced dementia;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Annual Reports;behavior change;Behavior Therapy;Behavioral;Biometry;Capsicum;catalyst;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Trials;Collaborations;collaborative environment;collaboratory;Communication;community setting;Databases;Decision Making;Dementia;Development;digital health;Educational Activities;Effectiveness;Elderly;Elements;Ensure;Evaluation;evidence base;Exercise;experience;Feedback;Fostering;Funding;General Hospitals;Gerontology;Goals;Grant;Grant Review;hands-on learning;Health;health disparity;Hospitals;improved;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;intervention mapping;Intervention Studies;Justice;Lead;learning strategy;Link;Massachusetts;medical schools;Mentors;Methods;Minority;Mission;Modeling;Monitor;Neurosciences;novel;Outcome;Outcomes Research;Palliative Care;Participant;Pilot Projects;Population;prevent;Prevention;preventive intervention;Process;Psychiatrist;Psychiatry;Psychologist;Public Health Schools;Racial Equity;Recording of previous events;Research;Research Infrastructure;Research Institute;Research Personnel;Research Training;Resource Allocation;Resources;routine care;Science;Scientist;Self Efficacy;skills;social cognitive theory;Societies;Structure;System;Teaching Method;Testing;theories;therapy design;therapy development;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Administrative Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Acceleration;African American;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;behavior change;Behavior Therapy;Behavioral;Caring;catalyst;Centers for Disease Control and Prevention (U.S.);Clinical Research;Clinical Trials;cohort;community setting;Dementia;Development;Diagnosis;digital health;Ensure;Evidence based program;Feedback;Fostering;Funding;General Hospitals;Gerontology;Grant;Grant Review;Health;health disparity;Hospitals;implementation science;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;Internal Medicine;Intervention;intervention mapping;Letters;Massachusetts;meetings;member;Mentorship;Minority;Mission;Modeling;Monitor;Neurosciences;novel;Outcome;palliative;Pathway interactions;Patient Care;Patients;Performance;Pilot Projects;pilot test;preference;prevent;preventive intervention;Procedures;Process;programs;Psychiatry;Psychologist;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;Sampling;scale up;Science;skills;Social Workers;Societies;sound;Structure;success;synergism;Technology;Testing;theories;therapy development;timeline;Training;Training and Infrastructure;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Behavioral Intervention Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: LEWIS AND CLARK COLLEGE

ORG_STATE: OR

PHR: Project Narrative Many human diseases are caused by aberrant lipid composition and rarely do we understand the mechanisms leading to the disruption of normal physiology. The C. elegans proteins being studied are homologous to human proteins that function in lipid metabolism. The proposed work will provide insights into how alterations in lipid biosynthesis and degradation can disrupt cellular physiology, which will provide fundamental knowledge that could lead to the treatment of disease.

PI_NAMEs: HERMANN, GREG J (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: acyl-CoA dehydrogenase;Adult;Amino Acids;Attention;Behavior;Biochemical;Biogenesis;Blood coagulation;Blood Platelets;C-terminal;Caenorhabditis elegans;Catabolism;Cell Physiology;cell type;Cells;Cellular Membrane;Characteristics;chediak-higashi syndrome;Chemicals;cold temperature;college;Cytoplasmic Granules;Cytosol;desaturase;design;Diagnosis;Diagnostic;Disease;Drosophila eye;Drosophila genus;Embryo;Endosomes;Exhibits;Family;Fatty Acid Desaturases;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;gene conservation;gene discovery;Generations;Genes;Genetic;genetic manipulation;Genetic Screening;Goals;Homeostasis;Hour;Human;human disease;Insecta;insight;Intestines;Knowledge;lipid biosynthesis;lipid metabolism;Lipids;Lysosomes;Measures;Mediating;Medical;Medium chain fatty acid;Melanosomes;member;Membrane;Membrane Fluidity;Membrane Lipids;Membrane Potentials;Metabolic;Metabolic Pathway;Mitochondria;Modeling;Morphology;mutant;N-terminal;novel;Organelles;oxidation;Parasites;Pathogenicity;Pathway interactions;peroxisome;Physiology;Piebaldism;Pigments;Polyunsaturated Fatty Acids;Process;Production;protein function;Protein Isoforms;Proteins;Repression;Role;Shapes;Signal Transduction;Syndrome;System;Temperature;Testing;trafficking;undergraduate student;Unsaturated Fatty Acids;Work

PROJECT_TITLE: Investigating the role of lipid metabolism in the biogenesis of lysosome-related organelles


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

PHR: RI-INBRE Narrative RI-INBRE is a network comprised of all nine universities and colleges in Rhode Island. RI-INBRE support of biomedical research in RI has significantly improved faculty-driven research and student training. This has helped position RI to substantially contribute to biomedical research in the region and the nation. Continued support of RI-INBRE is necessary to realize the full potential of this biomedical capacity building. Additional investment in the robust biomedical research framework in RI will maintain this upward trajectory, sustain the return on investments, and enhance the state's appeal as a destination for innovative research and biomedical investment.

PI_NAMEs: CHO, BONGSUP P (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Antibodies;Area;Award;Biological Markers;Biological Products;biomedical profession;Biomedical Research;career;Collaborations;college;Communities;community college;Complement;Core Facility;Data Science;design;Destinations;Development;Disadvantaged;Ensure;Equipment;experience;Extramural Activities;Faculty;Faculty Recruitment;Funding;Funding Mechanisms;Goals;graduate student;Grant;Hispanic-serving Institution;improved;Industry;Informatics;Infrastructure;innovation;Institution;institutional capacity;instrument;Investments;Mentors;Molecular;novel;Ointments;Organization administrative structures;Positioning Attribute;Postdoctoral Fellow;Program Development;Program Research Project Grants;programs;recruit;Research;research and development;Research Personnel;Research Training;Rhode Island;Structure;student training;Students;success;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Wales;willingness;Workforce Development

PROJECT_TITLE: Rhode Island IDeA Network of Biomedical Research Excellence

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Award;Biomedical Research;career development;catalyst;Categories;cohort;Collaborations;college;community college;Core Facility;curriculum development;Data Science;Development;Educational process of instructing;Ensure;Entrepreneurship;Environment;expectation;Faculty;Fellowship;Fellowship Program;Funding;Goals;Grant;Housing;improved;Informatics;institutional capacity;investigator training;Investments;Mentors;Modeling;Molecular;Nature;Ointments;operation;Participant;Performance;Positioning Attribute;Postdoctoral Fellow;Production;Program Evaluation;Program Research Project Grants;programs;Progress Reports;Recruitment Activity;Reporting;Research;Research Activity;Research Personnel;Research Support;Research Training;Rhode Island;sabbatical;Science;skills;student training;Students;Teacher Professional Development;Training;Training Activity;Training Programs;Training Support;undergraduate research;Underrepresented Students;Universities;Wales;Workforce Development

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Award;Biomedical Research;career;career development;cohort;Collaborations;college;community college;Complement;Data;design;Development;disadvantaged student;early-career faculty;Educational process of instructing;Educational workshop;Ensure;Environment;experience;Extramural Activities;faculty mentor;Fellowship;Fellowship Program;Funding;Funding Mechanisms;Goals;improved;Institution;institutional capacity;K-Series Research Career Programs;member;Mentors;Mentorship;Modeling;Ointments;Pathway interactions;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Research Training;Rhode Island;scaffold;Structure;student training;Students;summer program;Talents;Training;training opportunity;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Wales;Work

PROJECT_TITLE: Developmental Research Project Program