ADMINISTERING_IC: AT

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Electrical stimulation of nerve fibers has shown promise as an alternative treatment to drugs for chronic pain with less side effects but is still limited in efficacy for many patients. In the proposed program, we will develop and test a novel adaptive, model-based closed-loop peripheral nerve stimulation (CL-PNS) system optimized to change the dysfunctional pain system back to a normal physiological state. This CL-PNS system will be developed and tested using novel electrophysiological recordings from neurons in the spinal cord and the brain in naive and nerve-injured rats; and if successful, we will have the rationale and evidence for an effective therapy with a pathway for translation into humans in the future.

PI_NAMEs: GUAN, YUN ;SARMA, SRIDEVI V. (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Absence of pain sensation;Acute Pain;allodynia;alternative treatment;Anesthesia procedures;Animals;Back;Brain;cell type;chronic pain;computer framework;Computer Models;Data;Data Set;Deep Brain Stimulation;design;effective therapy;Electric Stimulation;Electrodes;Electrophysiology (science);Engineering;Exhibits;Feedback;Frequencies;Future;Human;Hyperalgesia;in silico;in vivo;in vivo evaluation;Injury;Knowledge;Local Anesthetics;Location;mathematical model;Measures;mechanical stimulus;model design;Modeling;Nerve Fibers;nerve injury;Neurons;neuroregulation;novel;novel therapeutics;opioid epidemic;Pain;Pain management;Pain Measurement;pain receptor;pain signal;painful neuropathy;Painless;Pathologic;Pathway interactions;Patients;Perception;Peripheral nerve injury;Peripheral Nerve Stimulation;Pharmaceutical Preparations;Pharmacologic Substance;Physiologic pulse;Physiological;Population;predictive modeling;Prevalence;programs;Rattus;Research;response;Role;sciatic nerve;side effect;Signal Transduction;Societies;Spinal Cord;Spinal cord posterior horn;Stimulus;Stroke;Syndrome;System;Techniques;technology platform;Testing;Thalamic structure;Therapeutic;therapy design;Time;Translations;Update;Width

PROJECT_TITLE: CRCNS: Computational Model of Chronic Pain Analgesia via Closed-Loop Peripheral Nerve Stimulation


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Traumatic brain injury (TBI) is a serious health care problem effecting millions of people annually and can lead to significant long-term problems associated with thalamic pathologies that can be altered by changes in the immune response. Microglia, the innate immune cells of the brain, are critical mediators of these neuroinflammatory processes that are initiated by TBI, however, little is known about microglial activation in the gyrencephalic brain which is more like human brains. This study aims to investigate the role of microglial process convergence onto injured axons following diffuse TBI in a higher order micro pig model, particularly as they relate to axonal outgrowth/retraction changes, diffuse thalamic pathology, P2YR12 expression, and sex differences.

PI_NAMEs: LAFRENAYE, AUDREY D (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adult women;Age;Agonist;Anti-Inflammatory Agents;arm;Autopsy;Axon;axon injury;Brain;brain cell;Brain Injuries;brain tissue;central nervous system injury;Clinic;Clinical Trials;Coculture Techniques;cohort;cytokine;Data;Diagnosis;Diffuse;Disease;Estrus;Family suidae;Female;fluid percussion injury;glial activation;Goals;Harvest;Healthcare;Hour;Human;human tissue;Immune;Immune response;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Influentials;inhibitor;Injury;Intervention;Investigation;male;Mammals;Mediating;Mediator;metabolic rate;Microglia;Microscopic;Modeling;Morbidity - disease rate;Mus;Nervous System Trauma;Neurites;Neuroimmune;neuroinflammation;Neurologic;neurological pathology;neuronal survival;Neurons;neuropathology;neurotoxic;novel;Pathologic;Pathology;Persons;Phenotype;Population;porcine model;postsynaptic;Preparation;Prevalence;Process;Proteins;Rattus;reconstruction;repaired;response;RNA;Rodent;Role;Sampling;sex;sex as a biological variable;Sex Differences;sex variable;Signal Transduction;Stretching;Swelling;targeted treatment;TBI treatment;Thalamic structure;Therapeutic;Tissues;TNF gene;Translating;Traumatic Brain Injury;treatment strategy

PROJECT_TITLE: Microglial process convergence following brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Emerging evidence indicates that the active recruitment of nerve fibers into tumors and subsequent cancer cell invasion (perineural invasion) plays an important role in cancer development, metastasis, therapeutic resistance, recurrence, pain, and death across many malignancies including pancreatic cancer, but the diverse molecular mechanisms underlying this tumor-nerve dialogue remain largely unknown. To address this gap in knowledge, we will comprehensively identify cell-type specific genes linked to perineural invasion in human pancreatic cancer and then investigate their functional roles in a novel genetically-engineered mouse model. The proposed studies will provide a high-resolution roadmap of critical gene expression programs and intercellular interactions in the pancreatic cancer microenvironment that facilitate perineural invasion, which will guide the repurposing and development of therapeutics against this pervasive cause of morbidity and mortality in pancreatic cancer and many other malignancies.

PI_NAMEs: HWANG, WILLIAM L (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Advisory Committees;Alleles;Area;axon guidance;Biochemical;Cancer Biology;cancer cell;Cancer Etiology;cancer initiation;Candidate Disease Gene;career development;Cell Communication;Cell Nucleus;cell type;Cells;Cessation of life;Coculture Techniques;cohort;Collaborations;Committee Members;CRISPR-mediated transcriptional activation;Critical Pathways;Custom;Data;density;Development;Development Plans;digital;Education;epidemiology study;Epithelium;Excision;experience;Fibroblasts;Formalin;Frequencies;Future;Gene Expression;Gene set enrichment analysis;Genes;Genetic Heterogeneity;Genetically Engineered Mouse;glial cell-line derived neurotrophic factor;Goals;Guide RNA;Heat-Shock Response;Human;human data;Immune;Immunofluorescence Immunologic;Immunohistochemistry;immunoregulation;improved;in vivo;in vivo Model;Invaded;Investigation;Kinetics;Knock-in;Knowledge;lentivirally transduced;Libraries;Link;Literature;live cell imaging;lymphatic Invasion;Machine Learning;machine learning classifier;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Mediator;medical schools;Mentors;Mesenchymal;Metabolic;migration;Molecular;Morbidity - disease rate;mortality;mouse model;multiplexed imaging;nano-string;Nature;Neoplasm Metastasis;neoplastic;neoplastic cell;Nerve;Nerve Fibers;neurogenesis;Neuroglia;neuron component;neuronal tumor;Neurons;neurotransmission;Non-Malignant;novel;organoid transplantation;Organoids;Outcome;Pain;Pancreas Transplantation;Pancreatic Ductal Adenocarcinoma;Paraffin Embedding;Pathologic;Pathologic Processes;Patients;perineural;Peripheral Nerves;Phenotype;Physicians;Play;preclinical study;preservation;Principal Investigator;Prognosis;programs;Property;Proteomics;recruit;Recruitment Activity;Recurrence;Research;Research Proposals;Resolution;Role;Sampling;Scientist;SEMA3E gene;single nucleus RNA-sequencing;spatial relationship;symposium;Synaptic plasticity;targeted treatment;Techniques;therapeutic development;therapy development;therapy resistant;Tissue Microarray;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;transcriptomics;transplant model;tumor;Tumor Biology;tumor microenvironment;tumorigenesis;tumorigenic;United States;Universities;Work

PROJECT_TITLE: Elucidating cancer-intrinsic mechanisms of perineural invasion in pancreatic cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Loss of tissue function through disease, accident, or aging is a cross-cutting problem in human health. Stem cells provide the capacity to generate new cells of specific types, making them attractive candidates for regenerating tissues; however, doing so requires a very high level of control over the environment immediately surrounding the cell. This proposal develops a class of new nanostructured materials targeted at designing precisely defined chemical and mechanical environments to control stem cell growth and differentiation, in order to generate new tissues or restore function in damaged tissue.

PI_NAMEs: CLARIDGE, SHELLEY ANN (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;Accidents;Address;Adhesions;Adopted;Aging;angiogenesis;Area;Behavior;Benchmarking;Binding;Biological;biomaterial compatibility;bone;Carbohydrates;Cartilage;Cell Adhesion;Cell Differentiation process;cell growth;Cell surface;Cell Transplantation;Cells;chemical property;Chemical Structure;Chemicals;Chemistry;Chondrogenesis;Clinical;Collagen;Cues;Deposition;design;Disease;Elements;Environment;experimental study;Extracellular Matrix;Fiber;Film;flexibility;functional loss;functional restoration;Future;Gel;Generations;Geometry;Goals;Health;Human;Hydrogels;Hypoxia;Implant;improved;in vivo;Individual;Injury;innovation;Length;Ligands;lipid biosynthesis;Lysine;mechanical properties;mechanical signal;Mechanics;Mesenchymal Stem Cells;meter;Modification;Modulus;Mus;Myoblasts;Nanostructures;Organ;Organ Transplantation;Osteogenesis;Pattern;Peptides;Perfusion;polyacrylamide;polydiacetylene;polydimethylsiloxane;prevent;Printing;Proliferating;Property;prototype;Regenerative Medicine;regenerative tissue;repaired;Resolution;scaffold;Shapes;Side;Signal Transduction;Site;Smooth Muscle Myocytes;Specific qualifier value;stem cell growth;Stem cell transplant;stem cells;stemness;Structure;success;Surface;Surface Properties;technology platform;Testing;Thick;Thinness;tissue regeneration;tissue support frame;Tissues;Transplantation;Transplantation Surgery;transplantation therapy;United States;volumetric muscle loss;Waiting Lists;wound healing

PROJECT_TITLE: Nanostructured Hydrogel Surfaces for Artificial Extracellular Matrix

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Services;Pain Research;Palliative Care;Patient Safety;Physical Activity;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project will demonstrate the efficacy of a yoga intervention to improve health utilization and quality of life as well as evaluate the cost-effectiveness of the intervention relative to a usual care comparison group in patients with head and neck cancer and their family caregivers.

PI_NAMEs: MILBURY, KATHRIN  (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Aftercare;Behavioral Medicine;Behavioral Sciences;Body Weight decreased;Breathing Exercises;Caregivers;caregiving;Caring;chemoradiation;clinical care;Communication;comparison group;Consent;coping;Cost Analysis;cost effectiveness;cost estimate;cost-effectiveness evaluation;data integration;Deglutition;Deglutition Disorders;design;Distress;Education;Effectiveness of Interventions;efficacy evaluation;efficacy trial;Emergency department visit;Emotional;Enteral Feeding;evidence base;Exclusion;Exercise;experience;facial disfigurement;Facilities and Administrative Costs;Family;Family Caregiver;Fatigue;follow up assessment;Fright;functional decline;Guided imagery;Head and Neck Cancer;head and neck cancer patient;Health;health care service utilization;high risk;Hybrids;improved;innovation;Institution;Intervention;intervention cost;Knowledge;Light;Location;loved ones;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Medical Care Costs;Medication Management;Modeling;Modification;Mucositis;nutrition;Opioid;opioid use disorder;Outcome;Pain;Pain management;Participant;Patient Self-Report;Patients;Personal Satisfaction;Persons;Physical Exercise;Physical Function;pilot test;pilot trial;Population;primary outcome;Procedures;productivity loss;programs;psychological distress;Qualitative Methods;Quality of Care;Quality of life;Randomized;Randomized, Controlled Trials;Records;Relaxation Techniques;Reporting;Research;Sampling;secondary outcome;Sleep disturbances;Source;Spouse Caregiver;Supportive care;Symptom Burden;symptom management;symptomatic improvement;Symptoms;Taxes;Toxic effect;treatment as usual;treatment duration;Treatment Protocols;tumor;usual care arm;Videoconferencing;Woman;Work;Yoga

PROJECT_TITLE: Improving Health Utilization and Quality of Life in Head and Neck Cancer Patients Undergoing Chemoradiation and their Family Caregivers

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This work will involve developing and deepening partnerships with underrepresented populations, as a necessary foundation for doing the transformative work to produce a general model for research that engages all communities involved in or considering being involved in genomic research. In addition, we will expand the involvement of diverse populations in genomic research and build capacity among American Indian and Alaska Native communities.

PI_NAMEs: CLAW, KATRINA G (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: absorption;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;Biological Assay;Cataloging;Clinical;clinical application;Communities;community engagement;community involvement;drug efficacy;drug metabolism;Drug Modulation;Drug Targeting;Ethics;Ethnic Population;Exclusion;Excretory function;Foundations;Gene Frequency;Genetic study;Genetic Variation;genomic variation;Genomics;Genotype;Geography;Goals;Guidelines;improved;in silico;in vivo;Individual;individualized medicine;Institution;inter-individual variation;intertribal;Knowledge;marginalized population;medication safety;Metabolism;Modeling;novel;Outcome;personalized medicine;Pharmaceutical Preparations;pharmacogenetic testing;pharmacogenetic variants;Pharmacogenetics;Pharmacogenomics;pharmacologic;Phenotype;Population;Population Heterogeneity;racial population;Research;Research Project Grants;response;Treatment Protocols;Tribes;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native People


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: TEMPE

ORG_DEPT: NUTRITION

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  The interdisciplinary Master’s in Biological Data Science (MSBDS) degree program’s Training in Genomics Research (TiGeR) Track is focused on training students with an undergraduate degree in computer science, mathematics, or statistics with limited or no previous experience working with genomics datasets. We will proactively recruit highly motivated candidates from racial and/or ethnic minority groups, those from sexual and gender minority groups, those with disabilities, and those from disadvantaged backgrounds who exhibit a firm commitment to research and academic excellence. The TiGeR Track is designed to integrate genomics research training into the MSBDS degree program through intensive hands-on exposure to genomics datasets and bioinformatic toolsets, as well as mentored research experiences.

PI_NAMEs: KANTHASWAMY, SREETHARAN  (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Academic skills;Active Learning;Agreement;Alaskan;Applications Grants;Area;Arizona;authority;Awareness;Bachelor's Degree;Big Data;biobank;Bioinformatics;Biological;Biological Sciences;Biology;Biomedical Research;Black race;career;career development;career preparation;Characteristics;cloud based;cohort;Communities;Complex;computational platform;computer science;Computer software;computerized data processing;Computing Methodologies;Copyright;Creativeness;Critical Thinking;Data;Data Analyses;Data Analytics;Data Collection;data repository;data reuse;Data Science;Data Set;data sharing;data visualization;data wrangling;Degree program;Degree requirements;design;Diagnosis;disability;Disabled Persons;disabled students;disadvantaged background;Disease;Doctor of Philosophy;Education;educational atmosphere;Educational Curriculum;Employment;Ensure;Environment;epigenomics;Ethics;ethnic minority population;Exercise;Exhibits;exome;experience;experimental study;Exposure to;Faculty;faculty mentor;FAIR principles;flexibility;Fostering;Foundations;gender minority group;Genes;Genetic;Genome;genome sciences;genomic data;Genomics;Goals;Guidelines;hands on research;hands-on learning;Health;Hispanic;human data;human disease;Human Genome;human genomics;human subject protection;improved;Indigenous;Individual;Industry;Informatics;Infrastructure;insight;Institution;Instruction;interdisciplinary collaboration;laboratory experience;Laboratory Research;large scale data;Learning;lectures;Machine Learning;Master of Science;mathematical sciences;Mathematics;Medical;medical specialties;Mentors;Modeling;Native Americans;Native Hawaiian or Other Pacific Islander;Natural Sciences;next generation;next generation sequence data;novel;Occupations;Ownership;Persons;Pharmacologic Substance;Population;predictive modeling;preservation;prevent;Process;professional students;Programming Languages;programs;Public Domains;Pythons;Qualifying;racial minority;recruit;Reproducibility;Research;Research Activity;Research Ethics;Research Institute;Research Personnel;Research Training;Resources;Schedule;Schools;Science;sexual minority group;skills;Societies;statistics;Structure;student participation;Student recruitment;student training;Students;summer internship;Target Populations;Techniques;tool;Training;Training Programs;translational genomics;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Visualization;whole genome;Work

PROJECT_TITLE: Training in Genomics Research (TiGeR)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Placental dysfunction has been associated with specific histopathology, particularly in the setting of preeclampsia and fetal growth restriction. Until recently, the inability to simultaneously obtain spatial and molecular data in a high-throughput manner and lack of proper in vitro model systems have limited the study of structure-function relationships in the human placenta. This project will use a combination of digital spatial profiling, placenta-derived extracellular matrix and primary cells, and mass spectrometry, to study cell-cell and cell-matrix interactions in the human placenta and associated alterations in the setting of placental dysfunction.

PI_NAMEs: PARAST, MANA M (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;Affect;Atlases;Basal Plate;Biological Models;Blood Vessels;cell injury;cell type;Cells;Chorionic villi;Clinical;cytotrophoblast;Data;Decidua;Deposition;Development;digital;Disease;Evaluation;experimental study;Extracellular Matrix;fetal;Fetal Growth Retardation;fetal loss;Fibrin;Functional disorder;Gases;Gene Expression;Heterogeneity;Histopathology;Human;in vitro Model;Injury;Interferons;Lesion;Maintenance;Mass Spectrum Analysis;Maternal-Fetal Exchange;Modeling;Molecular;Molecular Analysis;Molecular Profiling;Morphology;neonatal outcome;new technology;Nutrient;Organ;Paracrine Communication;Pathologic;Pathologist;Phenotype;Placenta;Placenta Diseases;Pre-Eclampsia;Pregnancy;prenatal;Proliferating;regeneration potential;Regenerative capacity;Reproducibility;response;RNA;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;stem;stem cells;Structure-Activity Relationship;Syncytiotrophoblast;Testing;Thrombosis;Tissues;transcriptome sequencing;trophoblast;Validation;Vascular Endothelial Cell;Villous

PROJECT_TITLE: Cellular Atlas of the Human Placenta: Structure-Function Relationships and their Implications for Placental Dysfunction

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative As newborn screening is now available for X-linked adrenoleukodystrophy, there is a need to establish meaningful disease markers to detect the onset of the severe demyelinating cerebral form of this disease at the earliest possible stage, and to quantify early disease progression to evaluate the relative efficacy of treatments. The proposed research study is relevant to public health because it may facilitate detection of neurocognitive and microstructural brain changes in individuals with emerging cerebral disease before MRI lesions appear and substantial neural injury has occurred, thereby improving outcomes for individuals with this difficult-to-treat neurological disorder.

PI_NAMEs: PIERPONT, ELIZABETH IRENE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 10 year old;Adrenal gland hypofunction;Adrenoleukodystrophy;Adrenomyeloneuropathy;Affect;Appearance;Attention;attentional control;Behavior assessment;Behavioral;Birth;boys;Brain;Brain Diseases;brain dysfunction;brain magnetic resonance imaging;career;career development;Cerebrum;Cessation of life;Child;Childhood;Clinical;Clinical Research Protocols;Clinical Trials;Clinical Trials Design;computerized;Computing Methodologies;Corpus Callosum;Data;Demyelinating Diseases;Demyelinations;design;Detection;Deterioration;Development;Development Plans;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disease Marker;Disease Progression;Early identification;Early treatment;effective intervention;Encephalitis;experience;Fiber;Fingers;Funding;Future;Goals;Guidelines;Hematopoietic Stem Cell Transplantation;human old age (65+);improved;improved outcome;Individual;Informal Social Control;interhemispheric transfer;Investigation;Investigational Therapies;K-Series Research Career Programs;Knowledge;Lesion;Link;Magnetic Resonance Imaging;male;Measures;Mentorship;Methodology;Methods;Minnesota;Modality;Monitor;Morbidity - disease rate;mortality;Myelin;Neonatal Screening;nerve injury;Nervous System Disorder;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuroimaging;neuroimaging marker;novel;novel therapeutics;Onset of illness;Outcome;Pathogenicity;Patient-Focused Outcomes;Patients;pre-clinical;prevent;programs;Protocols documentation;Public Health;Recommendation;Research;research and development;Research Design;Research Personnel;research study;Risk;screening program;statistical learning;Statistical Methods;stem cell therapy;Testing;tool;Training;translational scientist;Treatment Efficacy;Universities;Validation;Variant;white matter;Work

PROJECT_TITLE: Neurocognitive and neuroimaging markers of emerging cerebral adrenoleukodystrophy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Success in the field of neuroscience requires a broad understanding of the field as well as a deep understanding of research methodologies, experimental design, and quantitative reasoning. This program will provide its trainees with a broad foundation in neuroscience as well as the interdisciplinary skills needed to be successful within their neuroscientific careers. The students will be trained to be independent researchers, capable of making contributions in academia, teaching, industry, government, and public service.

PI_NAMEs: REDISH, A DAVID (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: pre-doctoral;Training

PROJECT_TITLE: Predoctoral Training of Neuroscientists


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE Drug abuse is an ongoing health concern. The goal of this competitive renewal is to continue support for a summer residential research program at the University of Minnesota with the hope of inspiring new generations of bright, talented undergraduate students, who are underrepresented in science, to pursue a career in the study of drug abuse. The hope is that these future scientists will contribute to the health infrastructure by discovering the mechanisms that underlie the neuroplasticity associated by the abuse of drugs, and to provide therapeutic measures to counteract these effects.

PI_NAMEs: MERMELSTEIN, PAUL G (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: Acute;Awareness;Biological Sciences;Biomedical Research;career;Career Choice;career preparation;college;Data Analyses;Data Collection;Dedications;Development;disabled;disadvantaged background;Discipline;Doctor of Philosophy;Drug abuse;Drug Addiction;Drug usage;Educational Curriculum;Educational workshop;effective therapy;Emotional;Enrollment;Evaluation;experience;Exposure to;faculty mentor;falls;Feedback;Functional disorder;Future;Generations;Goals;graduate school;graduate school preparation;Grant;Health;Home;Individual;Infrastructure;Institution;Instruction;interest;Laboratories;Laboratory Research;Learning;Letters;Measures;Medical;medical schools;Mentors;Mentorship;Minnesota;Modernization;National Institute of Drug Abuse;Nervous System;Neurobiology;Neuronal Plasticity;Neurosciences;next generation;Outcome;Pathway interactions;Personal Satisfaction;Pharmaceutical Preparations;Population;Positioning Attribute;posters;Preparation;programs;Publishing;Puerto Rico;recruit;Recruitment Activity;Research;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Schools;Science;Scientist;skills;social;Societies;Student recruitment;Students;success;summer program;summer research;summer student;Talents;Technical Expertise;Therapeutic;Time;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;Universities;Work

PROJECT_TITLE: Enhancing Student Diversity in Drug Addiction Research


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: STONY BROOK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative To understand biological processes in health and disease, and to develop drugs and other therapies, we need computational models for protein molecules and how they interact with each other in the wet environments inside and around our cells. Here we develop models based on physical principles and geometrical descriptions of the interactions that determine how proteins behave. These models will aid, for example, in: developing new classes of drugs, called macrocycles, that sandwich between proteins; developing antibody and other protein therapeutics; and understanding diseases such as Alzheimer’s and Huntington’s, which involve unhealthy clumping of proteins.

PI_NAMEs: COUTSIAS, EVANGELOS A.;DILL, KEN A (contact);FENNELL, CHRISTOPHER JOSEPH;KOZAKOV, DMYTRO ;SIMMERLING, CARLOS

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Affect;Affinity;aging population;Alzheimer's Disease;Amino Acids;Amyloidosis;Antibodies;Area;Binding;Binding Proteins;biochemical model;Biochemical Pathway;Biological;Biological Process;Biophysics;blind;Cells;Collaborations;Colloids;commune;Communication;Communities;Complex;Computational Biology;Computer Models;Decision Making;Dependence;design;Development;Diffusion;Dill;Disease;Docking;drug discovery;Environment;Equilibrium;Event;Excipients;flexibility;Formulation;Geometry;Goals;Health;high risk;Huntington Disease;improved;innovation;Intelligence;Joints;Leadership;Ligands;Liquid substance;Macrocyclic Compounds;Marketing;Mathematics;meetings;method development;Methods;Modeling;Molecular Conformation;Molecular Structure;Monoclonal Antibodies;Motion;Nerve Degeneration;Neurodegenerative Disorders;next generation;novel drug class;Paper;Persons;Pharmaceutical Preparations;Phase;physical model;physical property;Physics;Property;protein aggregation;protein folding;protein protein interaction;Proteins;Publishing;Quantum Mechanics;Radial;Research;Salts;screening;simulation;Slovenia;Solvents;Statistical Mechanics;Surface;System;Testing;theories;therapeutic protein;Time;Training;Viscosity;Water;web server;Work

PROJECT_TITLE: Solvation modeling for next-gen biomolecule simulations


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The study goal is to promote viral load suppression among women with serious mental illness (SMI) and HIV in Botswana, given that these women are especially vulnerable to psychiatric medication nonadherence and symptom exacerbation, which are made worse by stigma and threaten antiretroviral therapy (ART) adherence. We propose to test an intervention to reduce stigma due to the statuses of SMI and HIV, against an attention control condition, in the high-risk transition period after discharge from an initial psychiatric hospitalization. Enabling women with SMI and HIV to resist stigma has the potential to improve their HIV outcomes and empower these women to elicit broader, structural-level change.

PI_NAMEs: YANG, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 2 arm randomized control trial;Acute;Address;Adherence;Africa South of the Sahara;Ambulatory Care;antiretroviral therapy;arm;Articulation;Attention;attentional control;Binding;Botswana;Caring;Client;Communities;community reintegration;compare effectiveness;coping;Depressive disorder;depressive symptoms;Educational workshop;empowerment;Ensure;Face;Family;Family Caregiver;Family member;follow-up;Foundations;Funding;Future;Goals;Health system;high risk;HIV;Household;improved;inpatient psychiatric treatment;Inpatients;Intervention;intervention effect;Lived experience;marginalization;marginalized population;Measures;medication nonadherence;Mental Health;Modeling;Mothers;novel;Outcome;peer;Perception;personalized approach;Personhood;Persons;Pharmaceutical Preparations;Placebo Control;Policies;Policy Maker;post intervention;Postpartum Period;Pregnant Women;Prevalence;primary outcome;Professional counselor;Public Health;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Respondent;Risk;scale up;Schizophrenia;secondary outcome;Services;severe mental illness;Social outcome;social stigma;Symptoms;Testing;therapy adherence;therapy design;treatment adherence;Viral;Viral Load result;Woman;Women Status;women's outcomes

PROJECT_TITLE: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Chronic pain is a complex neurological disease associated with maladaptive structural and functional brain changes. It is prevalent in Veterans, adversely impacts their function and quality of life and is often treatment resistant. Spinal cord stimulation [SCS] is a minimally invasive, non-pharmacological therapy for treatment of chronic pain. However, little is known about how SCS impacts brain function. Our purpose is to evaluate neurophysiological response to SCS in individuals with chronic neuropathic pain. We will study two cohorts: Cohort 1 - naive SCS users (undergoing an SCS trial period) and Cohort 2 – long-term SCS users (≥6 months post implantation). We aim to identify the neurophysiological brain signature of pain relief using resting state Near Infrared Spectroscopy and Electroencephalography (rsNIRS/EEG). Results from this study will provide valuable information regarding the effects of SCS on the cortical connectivity networks during both trial SCS period and long-term SCS use in chronic neuropathic pain.

PI_NAMEs: PUNDIK, SVETLANA  (contact)

PROJECT_TERMS: Address;alternative treatment;Back;Biological Markers;Brain;chronic neuropathic pain;chronic pain;chronic pain management;Clinical;clinical care;clinical pain;cohort;Complex;control theory;conventional therapy;Data;Data Collection;dorsal column;Effectiveness;Electric Stimulation;Electroencephalography;Enrollment;EuroQOL;fighting;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Grant;Hour;Implant;implantable device;implantation;impression;improved;improved outcome;Individual;Information Systems;insight;Measurement;Medical center;Methods;minimally invasive;Monitor;Near-Infrared Spectroscopy;Nervous System Disorder;neuroimaging;neurophysiology;Neurostimulation procedures of spinal cord tissue;Nociception;Nonpharmacologic Therapy;Operative Surgical Procedures;Opiate Addiction;Outcome;Outcome Measure;Pain;Pain Clinics;Pain management;Pain Measurement;pain model;pain perception;pain relief;pain signal;painful neuropathy;Paresthesia;Participant;Patient Outcomes Assessments;Patient Selection;Patients;Pattern;Population;portability;Quality of life;Refractory;Regression Analysis;Research Design;Resistance;response;Rest;Spinal Cord Column;Structure;Syndrome;Techniques;Testing;Veterans;Visit

PROJECT_TITLE: Brain Connectivity Changes with Spinal Cord Stimulation Treatment of Chronic Pain: A Resting State NIRS/EEG Study

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative: Overall Component The Cole Eye Institute (CEI) Core Facilities for Vision Research will provide vision researchers essential resources to fulfill their mission. These resources include the ability to image eyes, measure changes in ocular functions and identify molecular alterations in vision threatening diseases by consolidating technologies in three core modules-(1) Ocular Imaging Core; (2) Functional Vision Core; and (3) Molecular Informatics Core. The Core facilities provide expertise in specific technologies and access to equipment to aid in the research endeavors of a vibrant and highly collaborative group of vision science investigators which will continue to increase productivity and avoid duplication of equipment and effort.

PI_NAMEs: ANAND-APTE, BELA  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Award;base;Basic Science;Blindness;Center Core Grants;Clinic;Clinical;Collaborations;Core Facility;Core Grant;cost;cost effective;Data;Development;Diabetic Retinopathy;Disease;Eligibility Determination;Environment;Equipment;experience;Eye;Faculty;Fostering;Foundations;Funding;Generations;Goals;Grant;Health Services Accessibility;Image;Individual;Informatics;Infrastructure;inherited retinal degeneration;Institution;instrumentation;Laboratories;Measures;Mission;Modification;Molecular;new technology;ocular imaging;operation;prevent;Productivity;programs;Publications;Reporting;Research;Research Infrastructure;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;Retinopathy of Prematurity;Scientist;Series;Services;sight restoration;skills;Source;square foot;Structure;success;Techniques;Technology;translational research program;Vision;Vision research;vision science;Visual System;Work

PROJECT_TITLE: NEI Center Core Grant for Vision Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Estrogen;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Gastrointestinal malfunctions and elimination of HIV reservoirs remain significant health issues for people living with HIV/AIDS in the era of anti-retroviral therapy (ART). Sex differences in immune activation and persistence have been reported but the mechanisms remain poorly understood. Our goal is to identify sex-specific immune parameters associated with viral persistence and rebound, which will be critical for developing personalized therapeutic strategies to reliably halt HIV-associated chronic diseases, and to target HIV reservoirs.

PI_NAMEs: CHANG, THERESA L (contact);VILLINGER, FRANCOIS J

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute infection;Animal Model;antiretroviral therapy;Area;Behavior;Binding;Blood;CD4 Positive T Lymphocytes;cell type;Cells;Chronic;Chronic Disease;cytokine;Disease Outcome;Disease Progression;Epithelium;ESR1 gene;Estrogens;Exhibits;Feedback;Female;Fluorescent in Situ Hybridization;Fostering;gastrointestinal;Gender;Gene Expression;Genes;Goals;Gut associated lymphoid tissue;Health;high risk;HIV;HIV Infections;HIV-1;HIV/AIDS;Human;Immune;immune activation;Immune response;Immune System Diseases;ImmunoPET;immunoregulation;in vivo;Infection;Inflammatory;insight;Interferon alpha;Interferons;Interruption;Intestines;Kinetics;Knowledge;longitudinal analysis;Longitudinal Studies;Macaca mulatta;Macrophage;male;Maps;men;Modeling;Molecular;Mucosal Immune Responses;Ovariectomy;Pathogenesis;Pathway interactions;Patients;Peripheral;personalized therapeutic;Persons;Production;Rectum;Reporting;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Role;sex;Sex Differences;Signal Transduction;simian human immunodeficiency virus;single molecule;Site;SIV;social engagement;Spatial Distribution;T-Cell Depletion;Technology;Testing;Therapeutic Intervention;Time;Tissues;transcriptome;transcriptome sequencing;Viral;Viral Load result;viral rebound;Viral reservoir;viral RNA;Virus;Virus Diseases;Virus Replication;Woman;Work

PROJECT_TITLE: Sex difference in intestinal immune dysfunction, SHIV infection and reservoir

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Advisory Committees;authority;Award;Center Core Grants;Core Grant;Data;Ensure;Equity;Eye;Fostering;Funding;Grant;improved;Individual;Institution;Leadership;Monitor;recruit;Research;research faculty;Research Personnel;Resources;service utilization;Services;Suggestion;Technology;Vision;Vision research;Visual System;Work

PROJECT_TITLE: CORE A - Administrative Core


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE My research program aims to identify the proteins and signaling pathways that coordinate mRNA translation to prevent catastrophic proteostatic collapse. Defects in translation, RNA-protein granules, and protein degradation are associated with degenerative conditions of the nervous, muscular, and skeletal systems, cancer, diabetes, aging, and neurodevelopmental disorders. A mechanistic understanding of protein homeostasis will aid in the development of novel therapeutic strategies to improve health across the lifespan.

PI_NAMEs: MOON, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;age related neurodegeneration;Aging;Alleles;Back;Cell Physiology;Cell Survival;Cells;Collaborations;Communication;Cytoplasmic Granules;Defect;Degenerative Disorder;Degradation Pathway;Development;Diabetes Mellitus;Eukaryota;Feedback;Feeds;Genes;Genetic Diseases;Genome engineering;Goals;hallmarks of aging;Health;Human;human disease;Human Genetics;Impairment;improved;Intervention;life span;live cell imaging;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Molecular;mRNA Translation;multicatalytic endopeptidase complex;muscular system;Nervous System;Neurodevelopmental Disorder;novel;novel diagnostics;novel therapeutic intervention;optogenetics;Outcomes Research;prevent;programs;Protein Biosynthesis;protein degradation;Proteins;Proteome;proteostasis;proteostasis loss;Quality Control;Regulation;Research;Research Personnel;response;RNA;Role;Signal Pathway;Skeletal system;Stress;stressor;System;Translation Initiation;Translational Regulation;Translational Repression;Translations;Ubiquitin;Work

PROJECT_TITLE: Mechanisms of Translation Regulation During Stress

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: BONILHA, VERA L (contact)

PROJECT_TERMS: animal imaging;Animal Model;Animals;cellular imaging;Center Core Grants;Clinic;clinical imaging;Collaborations;Computer software;Confocal Microscopy;Cryoultramicrotomy;Darkness;Data;Dedications;Disease Progression;Equipment;ex vivo imaging;experience;Eye;Faculty Recruitment;Fluorescence;Fluorescence Microscopy;Fostering;Freezing;Funding;Fundus photography;Generations;Grant;human imaging;Image;Image Analysis;image processing;imaging modality;Imaging Techniques;Immunohistochemistry;in vivo;in vivo imaging;innovation;instrument;instrumentation;Lasers;machine learning algorithm;microscopic imaging;Mus;ocular imaging;Ophthalmoscopy;Optical Coherence Tomography;Oryctolagus cuniculus;Paraffin;Paraffin Embedding;Pathway interactions;Plastic Embedding;Process;Productivity;programs;Protocols documentation;Rattus;recruit;Research;research faculty;Research Personnel;Research Support;Resources;sample fixation;Scanning;Scientist;Services;Stains;Standardization;Supervision;Talents;Techniques;Technology;Testing;Tissue Embedding;Tissue Fixation;Tissue imaging;tissue processing;Tissues;Training;Translational Research;Transmission Electron Microscopy;United States National Institutes of Health;Vision;Vision research;vision science;Visual System;Zebrafish

PROJECT_TITLE: Core B  Ocular Imaging Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project narrative The production of autoantibodies that are responsible for tissue damage in lupus as well as the production of protective antibodies against pathogens require two immune cell types, B and CD4 T cells, to interact. We propose to test the hypothesis that these cells use different energy sources for the production of autoantibodies and protective antibodies using mouse models. The ultimate goal of this project is to find ways to eliminate the cells producing autoantibodies while preserving immunity to pathogens.

PI_NAMEs: MOREL, LAURENCE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Adoptive Transfer;Affinity;Antibodies;Antigens;Autoantibodies;Autoimmune;Autoimmunity;autoreactive B cell;autoreactivity;B cell differentiation;B-Cell Activation;B-Lymphocytes;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Metabolic Process;Chronic;Deoxyglucose;Disease;disease model;ds-DNA;Energy-Generating Resources;Enzymes;etomoxir;experimental study;Explosion;fatty acid oxidation;FRAP1 gene;Frequencies;Funding;Genetic;genetic approach;Glucose;Glutamine;Glycolysis;Glycolysis Inhibition;Goals;Hypoxia;Immune;Immunity;Immunization;Immunoglobulin Class Switching;Immunoglobulin G;Immunophenotyping;in vivo;Influenza;inhibitor;Knowledge;Lupus;lupus prone mice;Metabolic;Metabolism;metabolomics;Modeling;mouse model;Mus;Norleucine;Oxidative Phosphorylation;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Population;preservation;Production;Program Sustainability;Proliferating;Proteins;Publishing;response;Role;Signal Transduction;single-cell RNA sequencing;Structure of germinal center of lymph node;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissues;transcriptomics;Translating

PROJECT_TITLE: Targeting follicular helper CD4 T cells in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision

PI_NAMEs: CRABB, JOHN W (contact)

PROJECT_TERMS: Acceleration;Animal Model;Area;Bioinformatics;Cells;Center Core Grants;Clinic;Collaborations;Complex;Consultations;Data;Data Analyses;Development;Disease;Doctor of Philosophy;experience;Experimental Designs;Eye;Eye diseases;Faculty;Fostering;Funding;Genomics;Goals;Grant;Human;Informatics;insight;instrumentation;metabolomics;metabolomics resource;Molecular;novel therapeutics;Ocular Pathology;Pathway interactions;Post-Translational Protein Processing;programs;protein protein interaction;Proteins;Proteomics;Qualifying;recruit;Research;research faculty;Research Personnel;Research Support;Resources;Scientist;Services;skills;System;Talents;Technology;Time;Tissues;Training;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Core C  Molecular Informatics Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Genetics;Heart Disease;Pediatric;Regenerative Medicine

ORG_CITY: SAN JOSE

ORG_DEPT: BIOLOGY

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: Project Narrative Newborn rodents possess a temporary but robust capacity for heart regeneration that is lost during the transition to adulthood. The proposed research is relevant to public health because it addresses the cellular and molecular mechanisms by which mammals lose the ability to regenerate their hearts after birth, and therefore will bear on the fields of heart development, tissue regeneration, and regenerative medicine. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries that ultimately protect and improve human health.

PI_NAMEs: PAYUMO, ALEXANDER Y (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: 3-Dimensional;Address;adenoviral mediated;Adolescent;Adrenergic Receptor;Adult;Birth;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiogenesis;Cause of Death;Cell Cycle;Cell Cycle Arrest;Cell Cycle Completion;Cell Cycle Inhibition;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cell Nucleus;Cells;combinatorial;Complementary DNA;Computer software;Creativeness;Cytokinesis;differential expression;digital;digital applications;Diploidy;Environment;Event;experience;First Independent Research Support and Transition Awards;Fluorescence;follow-up;Fostering;Functional Regeneration;Funding;Gene Expression;Genes;Goals;graduate student;Growth;Health;Heart;Heart failure;Holography;Hormonal;Hormones;Hour;Human;Hypertrophy;Image;improved;In Vitro;in vivo;Individual;Induced Cardiomyocytes;inhibitor;Injury;insight;Institution;ischemic injury;Label;Mammals;Measures;Mediating;Mentorship;Messenger RNA;Microscopy;minority trainee;Mission;Molecular;Molecular Target;Mus;Myocardial Infarction;Myocardium;Natural regeneration;Neonatal;Newborn Infant;non-invasive monitor;Norepinephrine;novel;nuclear division;Optics;overexpression;Pathway interactions;Physiologic pulse;Physiological;Ploidies;Polyploidy;postnatal;postnatal development;Proliferating;Public Health;Rattus;Receptor Signaling;regeneration potential;Regenerative capacity;Regenerative Medicine;Research;Resolution;response;RNA;Rodent;S phase;Serum;Signal Pathway;Students;Technology;Testing;three-dimensional visualization;Thyroid Hormone Receptor;Thyroid Hormones;Time;tissue regeneration;Training;transcription factor;transcriptome sequencing;transition to adulthood;treatment strategy;Triiodothyronine;undergraduate student;underrepresented minority student;United States;United States National Institutes of Health;Universities;Ventricular;Work

PROJECT_TITLE: Neurohumoral Interactions Coordinating Mammalian Cardiomyocyte Size and Proliferation


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: PERKINS, BRIAN D (contact)

PROJECT_TERMS: Animal Experiments;Animal Model;Behavior;behavior test;Behavioral Assay;behavioral response;Biological Assay;Brain;Cells;Center Core Grants;Clinic;Collaborations;Core Facility;Data;Data Set;Detection;Development;Disease;Electrophysiology (science);Electroretinography;Elements;equipment training;Eye;Eye diseases;Faculty;Fostering;Funding;Grant;Human;improved;insight;instrumentation;Light;Measurement;Measures;Methods;Mus;Ophthalmology;Patients;Pattern;Photoreceptors;Physiological;Productivity;programs;recruit;Reflex action;Research;research faculty;Research Personnel;Research Support;Resources;Scientist;Services;Signal Transduction;Stimulus;Talents;Technology;Testing;Tissues;Training;Treatment Efficacy;Vision;Vision research;Visual;Visual evoked cortical potential;Visual System;Zebrafish

PROJECT_TITLE: Core D  Functional Vision Module


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: In this proposal, we seek to understand the cellular programs engaged in autism spectrum disorder (ASD) by modifying the expression of hundreds of ASD relevant genes and measuring the effect on multiple cellular phenotypes in human neurons. We use innovative technologies to couple transcriptomic and morphological or electrophysiological readouts. We use the resulting datasets to finely annotate gene ontologies for these biological processes, and determine their disruption by neurons with reduced expression of defined ASD risk genes and neurons from patients with ASD.

PI_NAMEs: FARHI, SAMOUIL  (contact);NEHME, RALDA

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Affect;autism spectrum disorder;autoencoder;Binding;Biological Models;Biological Process;case control;Cell Culture Techniques;Cell Differentiation process;Cell model;Cells;Child;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Complement;Coupled;Coupling;CRISPR interference;Data;Data Analyses;data integration;Data Set;Disease;disease model;Electrophysiology (science);experience;experimental study;follow-up;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Diseases;Genetic Risk;genetic signature;Genetic study;Genetic Transcription;genetic variant;high dimensionality;Human;Human Genetics;human pluripotent stem cell;innovation;innovative technologies;insight;Intervention;invention;Investigation;Joints;knock-down;Link;Machine Learning;Measurement;Measures;Mental disorders;Methods;Molecular;Morphology;multimodality;multiple omics;multiplexed imaging;Neurobiology;Neurons;Ontology;Optics;Pathway interactions;Patients;Phenotype;postsynaptic;programs;protein protein interaction;rare variant;recruit;Research Personnel;response;risk variant;scale up;stem cells;success;System;Techniques;Testing;tool;transcriptomics;Undifferentiated;United States;Variant;Work

PROJECT_TITLE: Unraveling the Genetic Programs Engaged in ASD Neurons Through Coupled Transcriptomic and Phenotypic Readouts


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Violence Research

PHR: PROJECT NARRATIVE There is increasing evidence that gay, bisexual and other men who have sex with men (GBMSM) experience dual epidemics of HIV and intimate partner violence (IPV), yet understanding of the pathways between IPV and HIV risk is limited for GBMSM. The proposed 24 month cohort study examines associations between the experience and perpetration of IPV and immunological, biological and behavioral bio-markers of HIV risk among a large diverse sample of GBMSM in South East Michigan.

PI_NAMEs: KAHLE, ERIN M (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;AIDS prevention;alcohol tobacco and other drug use;ATOD;Behavior Control;Behavioral;Behavioral Research;behavioral response;Biological;biological adaptation to stress;Biological Markers;Bisexual;cohort;Cohort Studies;community advisory board;Complex;coping;Couples;Data;design;emotional abuse;Epidemic;experience;Female;Foundations;FOXP3 gene;Frequencies;Gays;Heterosexuals;HIV;HIV Infections;HIV risk;HIV Seronegativity;HLA-DR Antigens;IL2RA gene;Immune;immune function;Immune System Diseases;Immunologic Markers;Immunologics;inattention;Incidence;innovation;Interruption;Intervention;intimate partner violence;Knowledge;Link;male;Measures;Mediating;men;men who have sex with men;Michigan;minority stress;minority stressor;Monitor;Outcome;Pathway interactions;perpetrators;Phase;Prevalence;Process;prospective;psychological distress;Psychosocial Factor;Recommendation;Recording of previous events;recruit;Regulatory T-Lymphocyte;Reporting;Research;Research Activity;Research Personnel;resilience;Risk;Risk Behaviors;Role;Sampling;Sex Behavior;sexual violence;Shapes;social factors;social stigma;Social support;Stress;structural determinants;substance use;synergism;Theoretical model;therapy development;Time;Trauma;United States National Institutes of Health;Victimization;Violence;violence victimization;Woman

PROJECT_TITLE: Understanding Pathways between Intimate Partner Violence and HIV risk for Men


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: PROJECT NARRATIVE The research will identify the functional mechanisms for adaptive epidermal function. We will gain new knowledge from the proposed work that premised on human skin barrier evolution and a diverse set of skin from different ancestries. The translation of this knowledge will facilitate precision health treatments for inflammatory skin diseases.

PI_NAMEs: STRONG, CRISTINA DE GUZMAN (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Africa;African;African ancestry;Agonist;Alleles;ATAC-seq;Atopic Dermatitis;Binding;Biological Assay;Biology;casein kinase;CD4 Positive T Lymphocytes;Cells;Chromatin;chromatin immunoprecipitation;comparative;Complex;conditional knockout;Defect;design;Development;dosage;Ensure;Environment;Epidermis;European;European ancestry;Evolution;Exhibits;Flow Cytometry;Gene Expression;Gene Frequency;Genes;Genetic;Genetic Transcription;Geography;Goals;Haplotypes;Health;Homeostasis;Human;human migration;human population study;Immune;Impairment;in vivo;Individual;Infectious Skin Diseases;Inflammation;Inflammatory;involucrin;IRF1 gene;keratinocyte;knock-down;Knock-out;Knockout Mice;Knowledge;knowledge translation;Lead;Ligand Binding;Link;loss of function;Mediating;Molecular;multiple omics;Mus;NFIC gene;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Population;Precision Health;Precision Medicine Initiative;Production;Proteomics;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Regulation;RELA gene;Reporter;Reporting;Research;response;Risk;Risk Factors;Role;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;Skin;skin barrier;skin disorder;small hairpin RNA;T cell infiltration;Testing;Transcription Coactivator;transcription factor;transcriptome sequencing;TSLP gene;Variant;Vitamin D;Vitamin D3 Receptor;Work

PROJECT_TITLE: Skin Barrier Adaptation


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Stem cells are special cells that replicate many times over to give rise to all the tissues of the body in an embryo, replenish the tissues of the body over the life of an organism, and make the sperm and egg cells that go on to make the next generation. I study the relationship between stem cells and their supportive niche cells in a microscopic worm called C. elegans, which has many of the same cellular features as humans. I propose to follow up on my recent discovery that the niche and associated cells grow dramatically to support the stem cells, encourage their proliferation, and help them make sperm and eggs.

PI_NAMEs: GORDON, KACY LYNN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adhesions;Adult;Animals;Area;Behavior;Biological Models;Cadherins;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Cell division;Cell Fate Control;cell growth;Cell Proliferation;Cells;Cellular Structures;Complex;Cues;daughter cell;Development;egg;Embryo;follow-up;Genes;genetic analysis;genetic manipulation;Germ Cells;germline stem cells;Goals;Gonadal structure;Growth;Health;Human;imaging study;in vivo imaging;insight;Larva;Life;loss of function;Maintenance;Mediating;Microscopic;Modeling;Molecular;neglect;next generation;Organism;pandemic disease;Pathway interactions;programs;Proliferating;Regulation;Research;RNA Interference;self-renewal;Somatic Cell;Specific qualifier value;sperm cell;stem cell division;stem cell fate;stem cell model;stem cell niche;stem cell population;stem cell proliferation;stem cells;Stimulation of Cell Proliferation;Structure;success;System;Tissues;transcriptome sequencing;Undifferentiated;Work

PROJECT_TITLE: Extreme cell growth in support of stem cell proliferation and niche exit

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project narrative  Defects in maintaining proteins in the right cellular location results in various human diseases. This program seeks to understand how conserved mechanisms maintain the correct localization of proteins in the secretory pathway in the cell. This knowledge will shed light on the core principles of cell biology and uncover new therapeutic targets.

PI_NAMEs: SARDANA, RICHA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Anabolism;Cells;Cellular biology;Congenital disorders of glycosylation;Defect;Disease;Enzymes;Eukaryotic Cell;experimental study;Flow Cytometry;Functional disorder;Genetic;Glycoconjugates;Glycolipids;Glycoproteins;glycosyltransferase;Goals;Golgi Apparatus;Health;Homeostasis;Human;human disease;Image;Immune System Diseases;In Vitro;interest;Knowledge;Life;Location;Malignant Neoplasms;Maps;Membrane;Membrane Proteins;Membrane Transport Proteins;Molecular;new therapeutic target;novel;Pathway interactions;Play;Process;programs;Proteins;Proteomics;proteostasis;receptor;receptor recycling;reconstitution;Recycling;Role;solute;sugar nucleotide;Toxin;trafficking;vesicle transport;Virus

PROJECT_TITLE: Molecular mechanisms of membrane protein homeostasis at the Golgi

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Glaucoma is a group of neurodegenerative diseases that are identified by retinal ganglion cell (RGC) loss. Diverse astrocyte reactivity may contribute to axonal damage and RGC death by responding to extrinsic signals from different pathological contexts. In this project, I propose to study the molecular mechanism underlying cilia- dependent astrocytes reactivity in glaucoma pathogenesis and further regulate key signaling pathways to rescue RGC death by attenuating astrocytes reactivity in glaucoma.

PI_NAMEs: NING, KE VERONICA (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Acceleration;Address;Advisory Committees;Affect;aged;Astrocytes;astrogliosis;Attention;Attenuated;Axon;axon injury;axon regeneration;Blindness;Calcium;career;Cell Count;Cell Death;Cell membrane;Cell Physiology;Cell surface;Cell Survival;Cilia;Cilium Microtubule;Coupled;Cues;Data;Disease;Elderly;Exhibits;extracellular;Glaucoma;glial activation;Glial Fibrillary Acidic Protein;Goals;Heterogeneity;high risk;Human;Image;in vivo;Inflammatory;Injections;Injury;insight;Intraperitoneal Injections;Knockout Mice;Length;LoxP-flanked allele;member;Membrane;Mentors;Methods;Modeling;Molecular;mouse model;Mus;myelination;Nerve Crush;nerve damage;Nerve Degeneration;Neurodegenerative Disorders;neuroprotection;Neurosciences Research;novel;novel therapeutics;Ocular Hypertension;old mice;Optic Disk;Optic Nerve;optic nerve disorder;Organelles;overexpression;Pathogenesis;Pathologic;Pathway interactions;Pattern;Persons;Phase;Physiologic Intraocular Pressure;Play;Process;programs;Proteins;receptor;Recovery of Function;Research;response;Retina;Retinal Diseases;Retinal Ganglion Cells;Risk Factors;RNA;Role;Sampling;Sensory;SHH gene;Signal Pathway;Signal Transduction;Silicone Oils;single-cell RNA sequencing;smoothened signaling pathway;Tamoxifen;targeted treatment;Techniques;therapeutic target;Training;transcriptome;Transgenic Mice;United States;Viral;Vision;Work

PROJECT_TITLE: Primary Cilia of Astrocytes in Glaucoma


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative - Overall This proposal requests the funding of a consortium of three closely interacting, Boston-area cancer research groups whose joint focus is on new therapeutic vulnerabilities in breast cancer identified based on unbiased screens and by dissecting mechanisms of resistance to current therapies. Heterogeneity for phenotypic features such as proliferation and therapeutic sensitivity is a major challenge for cancer treatment. This consortium applies the latest available technologies and computational tools to understand drivers of epigenetic and transcriptomic heterogeneity in human breast cancer in order to reveal novel and effective means of treating these tumors.

PI_NAMEs: POLYAK, KORNELIA  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Address;Algorithms;anti-cancer research;Area;ATAC-seq;Automobile Driving;Bar Codes;Bioinformatics;Biological Process;Biomedical Research;Boston;Breast Cancer Cell;cancer cell;cancer therapy;CDK4 gene;Cell Cycle;cell type;chemotherapy;Clinic;Clinical;Clinical Management;clinical translation;Clinical Trials;Combined Modality Therapy;computerized tools;CRISPR screen;Cyclin-Dependent Kinase Inhibitor 2A;design;Development;Diagnosis;Disease;Disease Management;disease prognosis;Distant Metastasis;Endocrine;Epigenetic Process;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Exhibits;FDA approved;Fertilization;Funding;Future;genome-wide;Goals;Growth;Heterogeneity;Hormonal;hormone therapy;Hormones;Human;improved;Individual;insight;interest;Joints;Laboratories;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammary Neoplasms;Massachusetts;meetings;Molecular;Molecular Profiling;neoplastic;new therapeutic target;novel;novel strategies;novel therapeutics;Oncology;Pathogenesis;Pathology;Pharmaceutical Preparations;Phenotype;Play;Population;pre-clinical;Productivity;programs;Proliferating;Publications;Reagent;Recording of previous events;Request for Proposals;Research;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single-cell RNA sequencing;targeted treatment;Technology;Therapeutic;therapy resistant;Time;transcriptomics;triple-negative invasive breast carcinoma;tumor;Work

PROJECT_TITLE: New therapeutic vulnerabilities in breast cancer


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

PHR: Project Narrative The presence of distinct subpopulations of cancer cells within individual tumors is a major obstacle for effective treatment. This proposal aims to characterize the divergent routes taken by cancer cells in response to therapies, some of which enable them to successfully evade elimination. We aim to modulate these routes in order to reduce the ability of cancer cells to resist killing by anti-cancer therapeutic drugs.

PROJECT_TERMS: acquired treatment resistance;Affect;anti-cancer therapeutic;Bar Codes;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Bromodomains and extra-terminal domain inhibitor;cancer cell;cancer therapy;Cell Count;Cells;Chemoresistance;chemotherapy;ChIP-seq;Combined Modality Therapy;CRISPR screen;CRISPR/Cas technology;Data;design;Development;Disease Progression;Disease-Free Survival;Drug Tolerance;effective therapy;Endocrine;Enzymes;epigenetic drug;Epigenetic Process;epigenetic therapy;epigenomics;Estrogen Antagonists;Estrogen receptor positive;Evolution;experimental study;Frequencies;Genetic;genome-wide;Genomics;Goals;Heterogeneity;Histone H3;Histones;hormone therapy;Human;improved;In Vitro;in vivo;Individual;inhibitor;KDM5B gene;Knowledge;Lysine;Malignant Breast Neoplasm;Mammary Neoplasms;mathematical model;MCF7 cell;Molecular;neoplastic;novel therapeutics;Oncogenes;overexpression;Paclitaxel;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Population Dynamics;Prognosis;Publishing;Regulation;Reporting;Research;Resistance;resistance mechanism;response;Role;Route;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;small molecule;Specificity;synergism;synthetic lethal interaction;Testing;Therapeutic;Therapeutic Agents;therapeutic target;therapy resistant;Time;transcriptome;transcriptomics;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;Validation;Variant

PROJECT_TITLE: Epigenetic mechanisms of therapeutic resistance


NIH_SPENDING_CATS: Asthma;Clinical Research;Dental, Oral, and Craniofacial Disease;Lung

PHR: Narrative Asthma and chronic sinus disease currently afflict 8% and up to 12% of the US population, respectively, and both diseases have high morbidity and associated health care costs. We propose to uncover novel mechanisms that white blood cells use to cause inflammation in asthma and sinus disease that could lead to future therapeutic targets. Additionally, we will mentor junior clinical scientists in patient-oriented research as they will be leading the way for future treatment discoveries for these airway diseases.

PI_NAMEs: DOHERTY, TAYLOR A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: ACVR1 gene;Affect;Airway Disease;airway epithelium;airway inflammation;Allergic;Allergic Disease;Allergic rhinitis;Animal Model;antagonist;anti-IgE;Aspirin;aspirin-exacerbated respiratory disease;Asthma;asthmatic;Award;biobank;Bioinformatics;Biological;Biological Products;Biological Response Modifier Therapy;Blood;career;Cellular biology;chemokine;Chronic;chronic rhinosinusitis;Clinic;Clinical;clinical care;Clinical Investigator;clinical predictors;Clinical Trials;Cluster Analysis;Coculture Techniques;Color;Conduct Clinical Trials;cyclooxygenase 1;cytokine;Discipline;Disease;Eicosanoids;eosinophil;Eosinophilic Esophagitis;Epithelial Cells;Faculty;Flow Cytometry;Fostering;Funding;Future;Goals;Health Care Costs;Human;Hypersensitivity;Immunology;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inhibitor;inter-institutional;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Interleukin-5;Laboratories;Letters;Leukocytes;lipidomics;Lipids;Lung;Lymphoid Cell;Mediating;medical specialties;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);migration;Migration Assay;Mission;Morbidity - disease rate;Nasal Polyps;Nature;next generation;Nose;novel;Otolaryngology;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patients;Pattern;peripheral blood;Population;prevent;profiles in patients;Prostaglandin D2;Reaction;recruit;reduce symptoms;Research;Research Personnel;Research Proposals;Research Training;respiratory;response;Role;sample collection;Sampling;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;Sinus;Sputum;standard of care;STAT6 gene;statistics;Structure of mucous membrane of nose;Subgroup;Symptoms;Technology;Testing;therapeutic target;Time;Tissues;Training;transcriptome;transcriptomics;treatment response;Vocational Guidance;Work

PROJECT_TITLE: Mentoring patient-oriented researchers in inflammatory airway disease

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Estrogen;Genetics;Human Genome;Women's Health Research

PHR: PROJECT NARRATIVE  Endocrine therapies targeting the estrogen receptor (ER) are the mainstay of the systemic treatment of the more  than two-thirds of breast cancer patients with ER+ breast cancers. However, endocrine therapy resistant cancers  almost invariably emerge in patients with advanced disease and become the major cause of breast cancer-  associated deaths. Our study will develop systematic models to provide a deeper understanding of the complex  and heterogeneous endocrine therapy resistance mechanisms and will generate novel therapeutic strategies to  treat endocrine therapy resistant tumors and to prevent its emergence.

PI_NAMEs: BROWN, MYLES A (contact)

PROJECT_TERMS: advanced disease;Alleles;antagonist;Aromatase Inhibitors;Bar Codes;Binding;Biopsy;Breast Cancer Patient;cancer cell;Cell Line;Cells;Cessation of life;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR screen;Dana-Farber Cancer Institute;Data;Dependence;Development;Disseminated Malignant Neoplasm;Elements;Endocrine;Enhancers;Epigenetic Process;ESR1 gene;Estradiol;Estrogen decline;Estrogen Receptors;Estrogen Therapy;Estrogens;Exhibits;Feedback;Fulvestrant;Genes;Genetic;Genetic Screening;Genetic study;Genetic Transcription;genome-wide;Growth;Heterogeneity;hormone therapy;Immune;inhibitor;Investigation;Ligands;Link;Luteinizing Hormone-releasing Hormone Agonist;Malignant Breast Neoplasm;Mediating;Metastatic breast cancer;Modeling;Mus;Mutation;Neoplasm Metastasis;new therapeutic target;NF1 gene;novel;novel therapeutic intervention;novel therapeutics;patient derived xenograft model;Patients;pharmacologic;Phenotype;Phosphotransferases;Play;Postmenopause;Premenopause;prevent;programs;Proliferating;Property;PTEN gene;Receptor Gene;Receptor Signaling;refractory cancer;Resistance;Resistance development;resistance mechanism;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;src-Family Kinases;success;Tamoxifen;targeted treatment;therapy resistant;TSC1/2 gene;tumor;tumor heterogeneity;tumor microenvironment;tumor xenograft;Woman;Xenograft procedure

PROJECT_TITLE: Targeting Mechanisms of Endocrine Resistance in Breast Cancer


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative In this application we will study the link between ER stress and NOD1/2 immune signaling, which is of particular interest in intestinal inflammation since mutations in genes associated with ER stress (XBP1) and innate immune signaling (NOD2) have been associated with intestinal epithelial cell dysfunction. Salmonella Typhimurium (S. Tm) is a gram-negative intracellular pathogen and one of the most frequent causes of gastroenteritis in humans, however, it is currently unknown whether S. Tm induces ER stress in the intestine and what the consequences are on inflammation, colonization and pathology. Here we will investigate the different pathways downstream of the ER stress response and how they orchestrate intestinal inflammation in the Salmonella Typhimurium-induced colitis model.

PI_NAMEs: KEESTRA-GOUNDER, ARINA MARIJKE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Actins;Apoptosis;Apoptotic;ATF6 gene;Autophagocytosis;Bacterial Infections;Binding;biological adaptation to stress;Biological Process;Calcium;Calcium Signaling;Cell Death Induction;Cell Physiology;Cells;Colitis;Complex;conditional mutant;Cytoskeleton;Data;Development;dextran sulfate sodium induced colitis;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelial Cells;experimental study;Functional disorder;Future;Gastroenteritis;Gastrointestinal tract structure;Gene Expression;Gene Targeting;Genes;Gram-Negative Bacteria;gut inflammation;Homeostasis;Human;Immune response;Immune signaling;Immunologic Receptors;In Vitro;Induction of Apoptosis;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;interest;Intervention;intestinal epithelium;Intestines;Ligands;Link;Lipids;Mediating;Membrane;microbiota;Modeling;monocyte;Mus;Mutant Strains Mice;Mutation;Nutrient;pathogen;Pathogenesis;Pathology;Pathway interactions;Pattern recognition receptor;Peptidoglycan;Play;Population;Predisposition;Process;protein complex;Protein Inhibition;protein misfolding;Proteins;receptor;Regulation;release of sequestered calcium ion into cytoplasm;Resistance;Resources;response;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Signal Transduction;Source;sphingosine 1-phosphate;Streptomycin;Testing;Therapeutic;tissue/cell culture;Translations;Work;XBP1 gene

PROJECT_TITLE: The impact of ER stress on Salmonella Typhimurium infections

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

PHR: Project Narrative Inhibitors of cyclin-dependent kinases CDK4 and CDK6 are being used for treatment of breast cancer patients. The goal of this application is to increase the anti-cancer effect of this therapy, and to identify new combinations of CDK4/6 inhibitors and other compounds that would be more effective in targeting cancer cells.

PI_NAMEs: SICINSKI, PETER  (contact)

PROJECT_TERMS: Address;Affect;Allografting;anti-cancer;anti-CTLA4;anti-PD-1;anti-tumor immune response;Antibodies;Apoptosis;Blocking Antibodies;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;cancer cell;Cancer Model;cancer type;CDK4 gene;Cell Aging;Cell Cycle;Cell Death;Cell Proliferation;checkpoint therapy;Clinical Trials;Collaborations;combinatorial;Complex;Cultured Cells;Cyclin D1;cyclin D3;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinase Inhibitor 2A;Cyclin-Dependent Kinases;Cyclins;Cytostatics;cytotoxic;Development;efficacy testing;Enrollment;Estrogen receptor positive;Estrogen Therapy;Goals;Human;immune checkpoint;improved;In Vitro;in vivo;inhibitor;inorganic phosphate;Inter-tumoral heterogeneity;Laboratories;Ligands;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Mus;Nature;neoplastic cell;novel;novel therapeutics;Outcome;Pathway interactions;patient derived xenograft model;patient subsets;Patient-derived xenograft models of breast cancer;Patients;Pentosephosphate Pathway;Phosphotransferases;Play;programmed cell death ligand 1;programmed cell death protein 1;Protein Deficiency;Protein Isoforms;Proteins;Reactive Oxygen Species;Refractory;response;Retinoblastoma Protein;Role;Survival Rate;Testing;tumor;tumor heterogeneity;tumor metabolism;United States Food and Drug Administration;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Targeting CDK4 and CDK6 kinases in breast cancer development


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE This project will examine trends in prescribing and use of COVID-19-related drugs during the time before and after the pandemic among the Medicare population in outpatient setting, describing variation in their use across patients, as well as across physicians and geographic areas. We will also examine, in depth, three case studies of COVID-19-related drugs that received substantial public attention during the early months of the pandemic. We will describe changes in use associated with FDA safety communications and state policies intended to address hoarding; and investigate how use of these drugs varies by patient, physician and medical practice organization characteristics.

PI_NAMEs: KARACA-MANDIC, PINAR  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Rapid learning during a public health emergency: COVID-19 related medication treatment patterns in Medicare

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PROJECT_TERMS: Administrator;anti-cancer research;Boston;Budgets;Caring;Clinical Research;Collaborations;Combined Modality Therapy;Communication;Communities;computerized tools;Ensure;epigenomics;Feedback;Funding;Goals;Grant;Group Meetings;Logistics;Malignant Breast Neoplasm;meetings;member;Methodology;novel therapeutic intervention;novel therapeutics;Pathology;Principal Investigator;Program Research Project Grants;programs;Research;Resistance;Resource Sharing;Role;Schedule;Scientist;Suggestion;synergism;therapeutic target

PROJECT_TITLE: Administrative Core - New therapeutic vulnerabilities in breast cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

PI_NAMEs: DILLON, DEBORAH  (contact)

PROJECT_TERMS: Adaptive Immune System;anti-cancer research;Biological Assay;Biological Specimen Banks;Breast;Breast Cancer cell line;Breast Cancer Patient;breast pathology;Budgets;Cancer Center;Cell Line;cell stroma;cell type;Cells;Collaborations;Communities;community center;Dana-Farber Cancer Institute;Data Collection;Development;Distant;Evaluation;Fluorescent in Situ Hybridization;Foundations;Goals;Growth;Histologic;Hospitals;Human;Human Cell Line;Human Characteristics;human disease;human model;human tissue;Image;Immunocompromised Host;Immunohistochemistry;Institution;interest;Investigation;Knowledge;Laboratories;Link;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Microdissection;Modeling;Molecular;Molecular Analysis;molecular marker;Morphology;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Organoids;Pathogenesis;Pathologist;Pathology;Physiological;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programs;Research;Research Personnel;Research Project Grants;Resources;Retrieval;Services;Site;Stromal Cells;success;Tissue Banks;tissue preparation;Tissue Sample;Tissues;tumor;Woman;Xenograft procedure

PROJECT_TITLE: Tissue and Pathology Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Obesity-associated non-alcoholic fatty liver disease (NAFLD) is now the primary cause of liver cancer and the driver of the increase in this lethal disease. While certain gut bacteria have been implicated in NAFLD or NAFLD-induced liver fibrosis, longitudinal studies are needed to provide evidence for the temporal relationship. We will identify the kinds of gut bacteria and their metabolic pathways that are associated with increase in liver fat, more extensive liver stiffness, and increase in blood biomarker-based liver fibrosis over time in a prospective multiethnic study of underrepresented Asian Americans and Native Hawaiians, and Whites.

PI_NAMEs: HULLAR, MEREDITH ;LAMPE, JOHANNA W;LIM, UNHEE  (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;aged;Asian Americans;Bacteria;Behavioral;Bile Acids;Biological;Biological Markers;biomarker panel;Blood;blood-based biomarker;burden of illness;C-reactive protein;Cancer Burden;carbohydrate metabolism;Carbohydrates;chronic liver disease;Clinic;cohort;Communities;Data;Deposition;Diet;Dietary Component;Dietary Factors;Dietary Practices;Disease;Disease Progression;dysbiosis;effective therapy;elastography;Endotoxins;epidemiology study;Ethnic Population;Etiology;Fatty acid glycerol esters;Fatty Liver;Fibrosis;follow up assessment;follow-up;Fusobacterium;gut bacteria;gut microbiome;gut microbiota;Hawaiian population;high risk;high risk population;Image;improved;indexing;Inflammation;Inflammatory;Intervention;Investigation;Japanese American;Knowledge;Laboratories;Life Style;lipopolysaccharide-binding protein;Liver;liver cancer prevention;liver development;Liver diseases;Liver Fibrosis;liver stiffness;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measures;Mediating;Mediation;Metabolic Pathway;Metabolism;metagenomic sequencing;Metagenomics;Methods;microbial;mortality;multi-ethnic;Native Hawaiian;Native Hawaiian or Other Pacific Islander;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;Obesity;older adult;Participant;Pathway interactions;pharmacologic;Phenotype;phenotypic data;Plasma;Population;population based;prevent;prospective;Race;racial population;Random Allocation;Sampling;Secondary to;Severities;stool sample;Structure;systemic inflammatory response;Testing;Time;Toll-like receptors;trend;Viral hepatitis

PROJECT_TITLE: Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Excessive alcohol use, alcohol use disorder, and related consequences represent major public health problems in the US. Training researchers capable of understanding the causes and consequences of these problems by integrating biological, psychological, and social influences is essential to advancing alcohol and addiction science. This training program is intended to help develop the next generation of addiction researchers, able to adapt to rapidly changing science and function effectively in multidisciplinary research teams.

PI_NAMEs: MCCARTHY, DENIS M (contact);SHER, KENNETH JAMES

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: addiction;Alcohols;Psychology;Training

PROJECT_TITLE: Psychology of Alcohol and Addiction Training


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PI_NAMEs: LONG, HENRY W. (contact)

PROJECT_TERMS: ATAC-seq;Boston;Breast;Cancer Biology;cancer cell;Cell Line;cell preparation;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;cost effective;CRISPR screen;CRISPR/Cas technology;Dana-Farber Cancer Institute;Data;Data Set;Databases;design;Enhancers;Enzymes;Epigenetic Process;epigenetic profiling;epigenome;epigenomic profiling;epigenomics;experience;experimental study;follow-up;Genes;Genetic;genome editing;genome-wide analysis;Goals;Heterogeneity;Histones;innovation;Laboratory Scientists;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Methods;Mission;Molecular Profiling;novel therapeutics;Privatization;Productivity;programs;Quality Control;Reagent;Recording of previous events;repository;Research;Research Project Grants;Resources;Role;Services;sharing platform;single-cell RNA sequencing;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Validation

PROJECT_TITLE: Epigenomics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Caregiving Research;Childhood Obesity;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Recent advancements in wearable and wireless technologies, multivariate time-series analyses, and artificial intelligence has allowed scientists to further explore the predictive validity of therapy processes (therapeutic alliance, therapist empathy) to treatment outcome, and extend the assessment of these processes within and across sessions, and especially, in the treatment of ethnic minorities. The proposed study aims to use wearable biosensors, natural language processing, and innovative machine-learning (ML) models to more thoroughly examine within-session therapy processes and interpersonal synchrony, specially the role of therapist accurate empathy in the development and maintenance of the therapeutic alliance in the treatment of obese African American adolescents and their primary caregivers. The results of the study will provide much needed information on the dynamic and mutually influential dyadic interpersonal relationship between therapists and their ethnic minority clients.

PI_NAMEs: CUNNINGHAM, PHILLIPPE BELTON (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Acceleration;Accounting;Address;Adolescent;Affect;African American;African American population;Age;Agreement;American;analytical tool;Applied Research;Artificial Intelligence;Basic Science;Behavior;behavior change;Behavior Therapy;biopsychosocial;Caregivers;Classification;Client;Clinical;clinical encounter;Clinical Skills;clinical translation;Clinical Trials;Community Health Aides;Competence;Cultural Backgrounds;cultural values;Data;design;Deterioration;Development;Diabetes Mellitus;Discipline;Disparity;Dropout;Effectiveness;Elements;Emotional Bonds;Empathy;Ensure;ethnic minority;ethnic minority population;Ethnic Population;Evidence based treatment;Family;Feedback;Future;Galvanic Skin Response;Gender;Geographic Locations;Goals;Health;Health behavior change;Health Promotion;Heart Rate;heart rate variability;improved;Influentials;innovation;Interpersonal Relations;Intervention;Intervention Trial;Laboratories;Link;machine learning model;Maintenance;Measures;Mediating;Methodology;minority children;Minority Groups;Modeling;Monitor;multimodal data;multimodality;Natural Language Processing;Not Hispanic or Latino;Obesity;obesity treatment;Outcome;Patient Self-Report;Personality;Physiological;Physiology;practice setting;Prediction of Response to Therapy;premature;primary caregiver;Process;Process Assessment;programs;Provider;Psychotherapy;Public Health;Race;racial difference;racial population;randomized trial;recruit;Religion;repaired;Research;Research Design;response;Role;Rupture;Science;Scientist;Services;Sex Orientation;Signal Transduction;skills;Therapeutic;therapeutic development;therapy outcome;Time;Time Series Analysis;Training;Treatment outcome;Voice;wearable device;wearable sensor technology;Wireless Technology;Work;Youth

PROJECT_TITLE: Establishing an Artificially Intelligent Framework for Improving Therapeutic Alliance with Obese African American Youth and Caregivers through Multimodal Monitoring of Empathetic Accuracy and Interper

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Rural Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PI_NAMEs: THOMAS, GAIL D. (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: biobehavior;Biomedical Engineering;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;college;Communication;Communities;community engagement;Competence;Complex;Coupled;Data;Decision Making;Development Plans;Discipline;Discipline of Nursing;Doctor of Philosophy;Effectiveness;Elements;Entrepreneurship;Ethnic Origin;externship;Fertilization;Foundations;Funding;Goals;graduate student;Health;health disparity;Human;improved;Individual;interest;Intervention;Knowledge;leadership development;Medical Students;Medicine;Mentors;National Research Service Awards;Nutritional Science;Outcome;pre-doctoral;Process;programs;Public Health;Race;Research Project Grants;Research Training;Rural Health;Science;Scientist;skills;Social Sciences;Structure;Students;summer program;Time Management;Training;training opportunity;Transcend;Translational Research;Translations;undergraduate student;Universities

PROJECT_TITLE: J: Penn State NRSA Training Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative When looking around, we move our eyes 2-3 times every second to build up a visual representation of the scene and to get a deeper understanding about objects or people in the scene. Patients across a broad spectrum of neurological diseases (from Parkinson’s Disease to Autism) have abnormal eye movement behavior, yet our understanding of the neural mechanisms that guide normal behavior is limited, making it difficult to understand what is wrong in the diseased states. The results from this study will help us in understanding the roles that different areas of the brain play in guiding eye movements and may aid in the development of pharmacological or behavioral methods to combat these problems.

PI_NAMEs: BISLEY, JAMES  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Animals;Area;autism spectrum disorder;Behavior;Behavioral;Brain;Brain Stem;combat;Data;Development;Disease;expectation;Experimental Designs;experimental study;Eye;Eye Abnormalities;Eye Movements;frontal eye fields;Goals;interest;Knowledge;lateral intraparietal area;Learning;Maps;Methods;microstimulation;Nervous System Disorder;neural;neuromechanism;Neurons;oculomotor;Parkinson Disease;Patients;Persons;pharmacologic;Photic Stimulation;Plants;Play;prevent;Primates;Probability;Ramp;receptive field;response;Rewards;Role;Saccades;sample fixation;Scientist;Searching Behavior;Signal Transduction;Stimulus;superior colliculus Corpora quadrigemina;Testing;theories;Time;Update;Visual;Visual Fields;visual search;Work

PROJECT_TITLE: Elucidating the role of the oculomotor circuit in free viewing visual search

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Disorders of human communication commonly occur after stroke or head injury, or may appear in early childhood in the form of delayed language development, acquired or congenital hearing impairment, or impaired speech. Reducing the disabling effects of communication disorders on people requires a specialized, highly trained research workforce, relying heavily on a coordinated effort to provide newly emerging scientists with a comprehensive clinical perspective and skillset. The proposed training project is designed to prepare excellent new researchers in the discipline of communication sciences and disorders.

PI_NAMEs: STEPP, CARA E. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Advanced Research Training in Communication Sciences and Disorders


ORG_CITY: SANTA BARBARA

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative Precisely regulated organ form is important for proper body function. Microscopic analysis at the single cell level revealed active processes originating in the cytoskeleton drive cell shape changes that fuel tissue deformations. We will use emerging technology to establish the principles of cytoskeletal organization across entire organs, and lay the foundations of predictive models that connect genetic regulators to organ form.

PI_NAMEs: STREICHAN, SEBASTIAN J (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Advocate;Biological Models;Biophysics;Books;cell behavior;Cell Communication;Cell Shape;Cells;Congenital Abnormality;congenital heart abnormality;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;data handling;Defect;Development;Developmental Biology;DNA;Embryo;Emerging Technologies;Fluorescence Microscopy;Foundations;Gene Expression Regulation;Genetic;genetic information;Genetic Models;Genotype;Growth;Heart;Human;Image;imaging informatics;interdisciplinary approach;Investigation;Language;Learning;Life;Light;Mechanical Stress;Mechanics;Microscopic;Microscopy;Modernization;Molecular;Molecular Biology;Morphogenesis;morphogens;Organ;Organism;Pattern;Physics;predictive modeling;Process;Resolution;Rest;Seminal;Shapes;Technology;Time;Tissues;tool;transcription factor;Trees;Visit

PROJECT_TITLE: Physics of Living Matter: From Molecule to Embryo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The main objective of this proposal is to revise, based on previous pilot testing, our measure of Shared Decision-Making (SDM) for use in perinatal care. The Revised-CHildbirth Options, Information, and person- Centered Explanation (Revised-CHOICEs) evaluates SDM from the birthing person's perspective and more comprehensively considers decision points in perinatal care. This study will test the reliability and validity of Revised-CHOICES and determine whether the measure performs equally across different clinical situations and demographic groups.

PI_NAMEs: BREMAN, RACHEL B. (contact)

PROJECT_TITLE: A Measure for Shared Decision Making in Maternity Care through Communicating CHOICes, CHildbirth Options, Information, and person-Centered Explanation