ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The Delaware Comprehensive Sickle Cell Research Center (DE SCD COBRE) is a multidisciplinary research program focused on translational, clinical and psychosocial research in sickle cell disease. The overarching hypothesis of the Delaware Sickle Cell Research Program is that effective management of a common, congenital, multi-system disease requires comprehensive investigations spanning the biological, medical, psychological, and societal factors that affect both the severity of the disease and the efficacy of interventions. Future progress also requires specialty training of early career investigators with a commitment to the successful pursuit of independent funding.

PI_NAMEs: BROUSSEAU, DAVID C (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Achievement;Address;Adult;Affect;Area;barrier to care;Basic Science;Biological;Biological Markers;Biomedical Research;career;Caring;Centers of Research Excellence;Child;Child Health;Chronic;Chronic Disease;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Sciences;clinical trial enrollment;Clinical Trials;Collaborations;Communities;community engagement;comorbidity;Comprehensive Health Care;cost effective;Delaware;Disease;Disparity;Ensure;ethnic minority;Foundations;Funding;Future;Growth;Health;health care disparity;Health Personnel;Healthcare Systems;improved;Individual;Inequity;Informatics;innovation;Institution;Interdisciplinary Study;interest;Intervention;Investigation;Laboratory Research;Leadership;Maintenance;Medical;medical specialties;Mentors;Modeling;multidisciplinary;operation;Patients;Phase;Positioning Attribute;programs;Psychological Factors;psychosocial;racial minority;racism;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resource Development;Resources;routine care;Scientist;Secure;Self Efficacy;Senior Scientist;Severity of illness;Sickle Cell;Sickle Cell Anemia;social stigma;Societal Factors;success;System;tool;Training;Translational Research;translational research program;Treatment Efficacy;underserved community;young adult


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Hematology;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: KOLB, EDWARD ANDERS (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;African American population;Annual Reports;Area;autosome;Award;Benchmarking;Biomedical Research;Body System;career;Caring;Centers of Research Excellence;Child;Child Health;Chronic;chronic pain;Clinical;Clinical Research;clinical translation;clinical trial enrollment;Community Clinical Oncology Program;community engagement;Complex;Delaware;Development;Discipline;Disease;Disparity;Education;Elements;Ensure;Environment;experience;Functional disorder;Funding;Goals;Grant;Growth and Development function;Health system;Hematological Disease;Hemoglobinopathies;Hemolytic Anemia;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;life span;Maintenance;member;Mentors;Methods;Modeling;Monitor;multidisciplinary;National Cancer Institute;next generation;operation;Pediatric Hospitals;Pilot Projects;Policies;Procedures;Process;Program Development;Program Research Project Grants;programs;psychosocial;Quality of life;recessive genetic trait;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Scientist;Sickle Cell;Sickle Cell Anemia;Site;Strategic Planning;success;supportive environment;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Investment in training of biomedical engineers to become experts in the development of new non-invasive imaging tools and their use in patients with brain diseases such as schizophrenia and Alzheimer's Disease will greatly advance the ability to provide good medical care. The trainees from this program make significant contributions to medical technologies that enable accurate diagnosis of illnesses and determination of responses to treatments.

PI_NAMEs: ROSEN, BRUCE R (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: neuroimaging;Training Programs

PROJECT_TITLE: Neuroimaging Training Program


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Diabetes;Wound Healing and Care

ORG_CITY: Albuquerque

ORG_NAME: EXHALIX, LLC

ORG_STATE: NM

PHR: Project Narrative Lower limb chronic wounds in diabetic populations, often caused by chronic limb-threatening ischemia (CLTI), represents a significant global cause of morbidity, public health care burden, and a 5-year mortality rate exceeded only by lung cancer. Current therapeutic strategies are limited in their effectiveness to address the challenges due to diabetes-associated disruption of pathways involved in the healing response leading to changes in the wound environment including hyperglycemia-related microvascular changes. This proposal addresses the need for a novel therapeutic modality that improves local vascularization and accelerates healing of hard-to-heal wounds.

PI_NAMEs: SHEKARRIZ, REZA  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acceleration;Address;Adult;Advanced Development;Advanced Glycosylation End Products;Affect;Aftercare;aging population;Amputation;angiogenesis;Animal Model;Animals;Attention;Behavior;Biological Availability;Blood Circulation;blood perfusion;Blood Vessels;Chronic;chronic wound;Clinical;Clinical Research;clinically relevant;commercialization;cost effectiveness;Death Rate;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic rat;diabetic wound healing;Dorsal;Dose;effective therapy;Effectiveness;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Environment;Evaluation;Excision;Excision biopsy;Extracellular Matrix;Family suidae;Feasibility Studies;Female;Foot Ulcer;Functional disorder;Gangrene;General Population;Generations;Goals;Good Manufacturing Process;Government;Granulation Tissue;healing;healthcare burden;hemodynamics;Hepatotoxicity;Histologic;Human;Hydrogen Sulfide;Hyperglycemia;Hypotension;improved;In Situ;Infection;Infusion procedures;inhibitor;innovation;Ischemia;Laboratories;Lead;Leukocytes;limb amputation;Limb Salvage;Limb structure;Link;Lower Extremity;male;Malignant - descriptor;Malignant neoplasm of lung;manufacture;Mediating;Medical Device;meetings;Metabolic;Microvascular Dysfunction;Miniature Swine;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;necrotic tissue;New Mexico;Nitric Oxide;novel;novel therapeutics;open wound;Operative Surgical Procedures;Outcome;Pain;Pathway interactions;patient population;Patients;Performance;Perfusion;Peripheral arterial disease;personalized care;Persons;Phase;phase 1 study;phase 2 study;Physiology;Population;pre-clinical;pressure;product development;Production;prototype;Public Health;Publications;Punch Biopsy;Rattus;Recurrence;Reporting;Research;Research Personnel;Resources;response;Rest;revascularization;Risk;Safety;safety testing;sex;Signal Transduction;Signaling Molecule;Site;Skin;Small Business Innovation Research Grant;Sprague-Dawley Rats;Sterile coverings;Study models;success;Sulfides;Surgical incisions;Symptoms;System;Techniques;Technology;Testing;Texas;Therapeutic;Therapy Evaluation;Tissues;tool;Toxic effect;treatment duration;Ulcer;Universities;Validation;validation studies;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascularization;Visual;wound;wound care;wound closure;wound dressing;wound environment;wound healing;wound treatment

PROJECT_TITLE: HEALS™: An Active Hydrogen Sulfide Delivery Technique for Accelerated, Effective Wound Healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Data Science;Health Services;Hematology;Pain Research;Patient Safety;Pediatric;Rare Diseases;Sickle Cell Disease

PI_NAMEs: MILLER, ROBIN  (contact)

PROJECT_TERMS: Acute;Address;Adherence;Adult;Affect;African American;African American population;American;barrier to care;beta Globin;Birth;Caring;Centers of Research Excellence;Charge;Child;Child health care;Chronic;Clinical;clinical care;clinical center;Clinical Data;clinical infrastructure;Clinical Research;Clinical Sciences;clinical translation;cohort;Communities;Community Health Aides;Complex;Conduct Clinical Trials;cost effective;Data;Data Analytics;data dictionary;data modeling;Data Reporting;Data Science;data sharing;data standards;Delaware;Disease;Electronic Health Record;electronic health system;Enrollment;Ensure;evidence base;Fostering;Foundations;Gene Mutation;Health Care Costs;health care disparity;health care service utilization;human subject protection;improved;Informatics;Infrastructure;Inherited;Institution;knowledgebase;Life Expectancy;Mentors;Mentorship;Minority;Mission;mutation carrier;Organ;Outcome;Pain;Patient Care;patient population;Patients;Persons;phenotypic data;Population;Procedures;Quality of Care;Quality of life;Rare Diseases;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Standardization;standardized care;Techniques;Translational Research;vaso-occlusive crisis;Work;young adult

PROJECT_TITLE: Clinical Research and Data Informatics Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Lung;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE: This grant will test the hypothesis that Latexin contributes to endothelial dysfunction and microvascular thrombotic complications in the lung and that pharmacological strategies inhibiting its activities ameliorate the severity of acute lung injury in mice. Studies in this application are designed to advance our understanding of lung endothelial biology and foster the development of new approaches to the treatment of inflammatory vascular diseases of the lung, such as the acute respiratory distress syndrome.

PI_NAMEs: SUMMER, ROSS S;SUN, JIANXIN  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Accounting;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adherens Junction;Agonist;Alveolar;aspirate;Attenuated;Automobile Driving;Bacterial Pneumonia;Behavior;Binding;Biological Availability;Biology;Blood flow;Blood Platelets;Blood Vessels;cadherin 5;Cells;Cessation of life;Clathrin;Coagulation Process;Complex;Critical Illness;Data;Data Set;design;Development;Diabetes Mellitus;Edema;Endocytosis;Endothelial Cells;endothelial dysfunction;Endothelium;enhancer-binding protein AP-2;Enzymes;Exocytosis;Experimental Models;Exposure to;Extravasation;Floods;Fostering;Functional disorder;gain of function;Genes;Goals;Grant;Human;hypercholesterolemia;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Injury;innovation;insight;interest;interstitial;Investigation;knock-down;Knockout Mice;Knowledge;Laboratories;Length of Stay;Link;Lipopolysaccharides;loss of function;Lung;lung injury;Mass Spectrum Analysis;Mediating;Membrane;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Obesity;Organ;organ injury;Pathogenesis;Pathogenicity;Pathologic;PC3.1 antigen;pharmacologic;Phosphorylation;Plasma;Platelet Activation;Play;prevent;Proteins;Pulmonary Edema;Pulmonary Inflammation;pulmonary vascular disorder;respiratory;Respiratory Failure;response;Role;Sepsis;Severities;shear stress;Signal Transduction;SNAP receptor;SNAP23 gene;src-Family Kinases;syntaxin 3;Testing;Thrombosis;thrombotic complications;tool;trafficking;transcriptome sequencing;translational progress;Up-Regulation;Vascular Diseases;von Willebrand Factor

PROJECT_TITLE: Targeting Latexin Signaling for Endothelial Barrier Dysfunction in Inflammatory Lung Injury


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Bone loss is a severe complication of HIV-infection that is exacerbated by antiretroviral therapy (ART) in a manner that vary widely from person to person. Defining the mechanisms underlying this loss and identifying biomarkers that predict its severity are necessary to ongoing efforts aimed at devising preventive strategies to preserve/restore bone mass and to prevent bone fractures in aging people living with HIV/ART.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;OFOTOKUN, IGHOVWERHA  (contact);WEITZMANN, MERVYN NEALE

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;Acute;Adult;Age;Aging;Animals;Anti-Retroviral Agents;Antibiotics;Antigen Presentation;Antigens;antiretroviral therapy;Atrophic;Automobile Driving;B-Lymphocytes;Bacteria;Basic Science;biomarker identification;bone;Bone Density;Bone Diseases;bone loss;Bone Marrow;bone mass;Bone Resorption;bone turnover;Cells;Clinical Research;Clone Cells;Complication;cytokine;Cytoprotection;Data;Disease;Equilibrium;Estrogen deficiency;experience;Feces;Fracture;Future;Grant;gut microbiota;HIV;HIV Infections;Human;Hyperparathyroidism;IL17 gene;Immune;immune activation;immune reconstitution;Immune system;immunodeficiency;Immunologic Markers;indexing;Inflammation;Inflammatory;inflammatory bone loss;inhibitor;Integrase;Interleukin-1;Interleukin-6;Intervention;Intestinal permeability;Leaky Gut;Ligands;Metagenomics;microbial;microbiome;microbiota;microorganism antigen;Modernization;mouse model;Mus;Natural regeneration;NF-kappa B;normal aging;Osteoblasts;osteoclastogenesis;Osteoclasts;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiological;predictive marker;Predisposition;preservation;prevent;Prevention strategy;preventive intervention;Probiotics;Process;Production;receptor;Recovery;Regimen;Rejuvenation;Reporting;response;Risk;risk stratification;Role;Serum;Serum Markers;Severities;Shotgun Sequencing;Skeletal system;Skeleton;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Tenofovir;Testing;Therapeutic;Thymus Gland;Time;TLR4 gene;Toll-like receptors;Tumor necrosis factor receptor 11b;Virus;Work

PROJECT_TITLE: Predictors of Antiretroviral Immunereconstitution Bone Loss - the Gut and the Microbiome

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE – P01, Clinical Care Gaps and Unmet Needs in AYA Cancer Survivors  This program of research is focused on the cancer care experience of adolescents and young adults (AYAs) who are diagnosed with cancer during the ages of 15 to 39 years. It involves three research projects, focusing on different aspects of care relevant to AYAs: preservation of fertility and impact on cancer care, coordination of care among multiple providers including during the transition from active cancer treatment to surveillance and follow-up, and late effects that AYA cancer survivors may experience. These projects are supported by three cores that provide biostatistical, survey, and administrative support to program activities.

PI_NAMEs: CHUBAK, JESSICA ;HAHN, ERIN ELIZABETH;KEEGAN, THERESA H M;KUSHI, LAWRENCE H (contact);NICHOLS, HAZEL B

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Advocate;Aftercare;Age;aged;Ambulatory Surgical Procedures;Area;barrier to care;Biometry;Breast;California;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cardiovascular Diseases;care coordination;care preference;career;Caring;Child;child bearing;Childhood;Chronic;clinical care;Colorectal;Continuity of Patient Care;Counseling;Data;data harmonization;data resource;Diagnosis;Disparity;Emergency department visit;Employment;Endocrine System Diseases;Epidemiologist;Ethnic Origin;evidence base;experience;Face;Family;Fertility;fertility preservation;Financial Hardship;follow-up;Goals;Guidelines;Health;health care service utilization;health care settings;Health Insurance;Health Resources;Health Services;Health system;Healthcare;higher education;Home;Hospitalization;improved;improved outcome;Incidence;Individual;Inpatients;Insurance;Insurance Coverage;Interdisciplinary Study;interest;Kidney Diseases;Knowledge;Late Effects;Life;Link;Liver diseases;Lymphoma;Malignant neoplasm of testis;Malignant Neoplasms;Medical;multidisciplinary;National Cancer Institute;National Comprehensive Cancer Network;neglect;Neighborhoods;neoplasm registry;North Carolina;older adult;Older Population;Oncologist;Outcome;Outpatients;Patient Preferences;Patient-Centered Care;Patients;Persons;Phase;Population;Population Database;population health;Population Surveillance;preservation;Preservation Technique;programs;Provider;Puberty;Race;Recommendation;Reporting;Reproductive Health Services;Research;Research Personnel;Research Project Grants;Resource Sharing;Respiratory Disease;Risk;Second Primary Cancers;Services;Socioeconomic Status;Specialist;Surveys;survivorship;United States;Universities;University resources;Utah;Visit

PROJECT_TITLE: Clinical Care Gaps and Unmet Needs in Adolescent and Young Adult (AYA) Cancers


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Infertility;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE – Project 1, Fertility and Cancer Care Delivery in AYAs  Fertility is a primary concern of many adolescents and young adults (AYAs) with cancer. This project will address receipt of guideline-recommended fertility counseling and use of fertility preservation strategies as part of the P01’s goal to address the unique challenges of AYAs across the care continuum. The proposed research will identify disparities in the delivery of fertility services and quantify the impact of fertility-related decisions on the timing of cancer treatment initiation and persistence across multiple cancer types.

PI_NAMEs: NICHOLS, HAZEL B (contact)

PROJECT_TERMS: Accreditation;Address;adjuvant endocrine therapy;Adolescent and Young Adult;Adolescent and young adult cancer patients;Age;Antineoplastic Agents;breast cancer diagnosis;California;cancer care;cancer diagnosis;cancer health disparity;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;care delivery;Caring;chemotherapy;clinical care;community center;Consumption;Continuity of Patient Care;cost;Counseling;Data;Databases;Desired Family Sizes;Diagnosis;Disease;Disparity;Documentation;Education;Electronic Health Record;Elements;embryo cryopreservation;Epidermal Growth Factor Receptor;Estrogen receptor negative;Estrogen Receptors;Ethnic Origin;Ethnic Population;experience;Female Adolescents;Fertility;fertility improvement;fertility preservation;Fright;Future;Gender;Goals;Guidelines;Health Resources;Healthcare;Healthcare Systems;Hodgkin Disease;Human;Impairment;improved;Income;Insurance;insurance claims;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Male Adolescents;Malignant Breast Neoplasm;Malignant neoplasm of testis;Malignant Neoplasms;Medical;medical appointment;Medical Records;medical specialties;meetings;men;Methodology;neoplasm registry;North Carolina;Oncology;oocyte cryopreservation;Operative Surgical Procedures;Parents;Participant;patient subsets;Patients;Pediatric Oncology;population health;preservation;Preservation Technique;Procedures;programs;Provider;provider factors;Puberty;Race;racial minority population;Radiation therapy;Recommendation;Records;Reporting;reproductive;reproductive outcome;Reproductive Technology;Research;Rural;Sampling;Services;Socioeconomic Status;socioeconomics;Specialist;sperm cryopreservation;Surveys;survivorship;System;Therapeutic;therapy development;Time;Training;Translating;treatment adherence;Treatment outcome;treatment pattern;treatment risk;tumor;unconscious bias;Universities;Woman;young woman

PROJECT_TITLE: Project 1: Fertility and Cancer Care Delivery for Adolescents and Young Adults


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE – Project 2, Patterns of Care and Care Transitions in AYA Cancer Survivors  The goal of this project is to investigate patterns of healthcare utilization among adolescent and young adult (AYA) cancer survivors, assess patient-reported care experiences and barriers to appropriate care during early survivorship, and understand associations between concordance with national clinical care guidelines and patient-reported outcomes. We will use data from multiple healthcare systems and state-based resources and reports from AYA cancer survivors themselves to generate essential insights to improve care and outcomes for this population.

PI_NAMEs: HAHN, ERIN ELIZABETH (contact)

PROJECT_TERMS: Accident and Emergency department;active method;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adolescent Health Services;Adverse effects;Adverse event;Affect;Aftercare;Age;aged;barrier to care;Breast;California;cancer care;Cancer Center;cancer site;Cancer Survivor;cancer type;Cardiovascular Diseases;care coordination;Caring;Characteristics;Classification;Clinical;clinical care;Colorectal;Communication;Complement;Consensus;Continuity of Patient Care;Data;data resource;Data Set;Databases;demographics;Detection;Diagnosis;Disease;Distress;diverse data;Educational Status;Electronic Health Record;Electronics;Emergency medical service;Emotional;emotional distress;Employment Status;Endocrine System Diseases;evidence base;experience;Face;follow-up;Frequencies;Geographic Locations;Geography;Goals;Guidelines;health care service;health care service utilization;health related quality of life;Healthcare;Healthcare Systems;Hodgkin Lymphoma survivors;Hospitalization;improved;Individual;innovation;inpatient service;insight;Integrated Health Care Systems;Intervention;Knowledge;Life Cycle Stages;Link;Lymphoma;Malignant neoplasm of testis;Malignant Neoplasms;Marital Status;Measures;medical specialties;member;Methods;multiple data sources;National Comprehensive Cancer Network;neoplasm registry;North Carolina;Outcome;outpatient programs;Patient Care;Patient Outcomes Assessments;Patient Self-Report;patient variability;Patient-Centered Care;patient-clinician communication;Patients;Pattern;Patterns of Care;peer;Perception;Population;population based;Preventive care;Program Research Project Grants;programs;Provider;provider communication;psychosocial;Quality of Care;Recommendation;Reporting;Research;Resources;Science;Second Primary Cancers;service utilization;Services;Site;Subgroup;Surveys;Survival Rate;Survivors;survivorship;Symptom Burden;System;Systems Integration;Training;treatment pattern;United States;Utah;Variant;Visit

PROJECT_TITLE: Project 2: Patterns of Care and Patient Experiences During Early Survivorship Among AYA Cancer Survivors


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE – Project 3, Late Effects in the AYA Cancer Population  This project will study the late effects of cancer treatment, including cardiovascular and endocrine diseases, in adolescent and young adult (AYA) cancer survivors. We will identify demographic, clinical, and healthcare factors that influence risk of late effects and determine how disparities in health insurance, finances, care coordination and other factors impact late effects in AYA survivors. Findings from this study will help researchers and healthcare providers improve monitoring of cancer survivors and detect late effects earlier.

PI_NAMEs: KEEGAN, THERESA H M (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Affect;Aftercare;Age;age group;Ambulatory Surgical Procedures;Area;Asthma;barrier to care;Biological;Body System;California;Cancer Detection;Cancer Patient;cancer survival;Cancer Survivor;cancer survivorship care;cancer therapy;cancer type;Cardiovascular Diseases;Cardiovascular system;care coordination;care seeking;Caring;Childhood;Childhood Cancer Survivor Study;Chronic;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Cirrhosis;Clinical;clinical care;clinical infrastructure;cohort;Comprehensive Health Care;cost;Country;County;Data;data resource;Diabetes Mellitus;Diagnosis;Disparity;disparity reduction;diverse data;Drug Kinetics;Early Diagnosis;Electronic Health Record;Employment;Endocrine;Endocrine System Diseases;Ethnic Origin;evidence based guidelines;experience;Face;Fertility;Financial Hardship;follow-up;Goals;Guidelines;Health;health care service;health care service utilization;health disparity;Health Insurance;Health Personnel;Health system;Healthcare;High Prevalence;high risk;Hospitalization;Hospitals;improved;Incidence;Individual;Inpatients;Insurance;Insurance Coverage;Integrated Health Care Systems;Intervention;Investigation;Kidney Failure;Late Effects;Life;Link;Liver diseases;Long-Term Care;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;medical specialties;medically underserved;Monitor;Necrosis;Neighborhoods;neoplasm registry;North Carolina;Oncology;Outcome;Outpatients;Patients;Phase;Population;population based;Population Intervention;Prevention;preventive intervention;Primary Care;programs;Provider;Race;racial difference;Registries;Reporting;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;respiratory;Risk;rural dwellers;rural underserved;Second Primary Cancers;social factors;Socioeconomic Status;Source;Specialist;Stroke;Surveys;Survivors;survivorship;System;Utah;Visit;young cancer survivor

PROJECT_TITLE: Project 3: Chronic Medical Conditions and Late Effects in the AYA Cancer Population


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed research is relevant to future applications of and innovations in neuroscience because it seeks to open the field to more people from diverse backgrounds by providing meaningful, reinforcing experiences and a supportive network for underrepresented, minorities, disadvantaged and/or disabled, and rural 6th-8th grade students as they explore potential opportunities in neuroscience. In the proposed work, we will lead students through multiple neuroscience programs, including a novel curriculum, a summer immersion camp, and a year-long mentorship program, and in doing so we will integrate three forms of engagement experiences into a single synergistic and cohesive engagement ecosystem for participants to better envision a future for themselves in higher education and in neuroscience more specifically. The project will support NIH’s commitments to building participation in research careers through the integration of successful yet disparate single-organization practices into a unified and longitudinal statewide model.

PI_NAMEs: RANDOLPH, ANITA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Achievement;Active Learning;Address;aspirate;Awareness;Brain;career;Caring;cohort;Collaborations;college;Communities;Country;County;curriculum development;Databases;Development;developmental psychology;disability;disabled;Disadvantaged;Discipline;Disparate;Ecosystem;Education;education planning;Educational Curriculum;Educational process of instructing;eighth grade;Ethnic Origin;experience;Faculty;Future;Generations;Goals;graduate student;higher education;Immersion;Individual;innovation;interest;Investments;junior high school;Lead;Learning;Life;London;marginalized population;member;Mental Health;Mentors;Mentorship;Middle School Student;Minnesota;Minority;Modeling;Nervous System Disorder;Neurosciences;Neurosciences Research;next generation;novel;novel strategies;Oregon;Participant;Persons;Play;Population;Process;programs;Race;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Rural;School-Age Population;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self Concept;Shapes;skills;social;STEM field;student participation;Students;success;teacher;Time;Trainers Training;Training;Twin Cities;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;volunteer;Washington;Work;Youth

PROJECT_TITLE: Positive STEM Experiences for Underrepresented and Rural 6-12th Graders: A Novel Approach to Pre-Collegiate Neuroscience using a Train-the-Trainer Model, Summer Immersion, and Sustained Mentorship

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Adults with Down syndrome experience an early age of onset and increased risk for Alzheimer's disease. The proposed study addresses this public health crisis and advances science by providing the first longitudinal investigation of the effect of four lifestyle factors (physical activity, sleep, cognitive stimulation, and social engagement) on the age of onset of early Alzheimer's neurodegeneration and on the timing of the transition to clinical dementia in adults with Down syndrome. These lifestyle factors may be important modifiable resiliency mechanisms for delaying Alzheimer's disease in adults with Down syndrome despite their genetic risk.

PI_NAMEs: HARTLEY, SIGAN L (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta accumulation;Abeta synthesis;actigraphy;Address;Adult;Age;Age of Onset;Aging;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Attenuated;Automobile Driving;Biological Markers;Blood;Chromosome 21;Chronology;Clinical;clinical risk;Cognition;Cognitive;cognitive function;cohort;Data Collection;Dementia;Development;Down's Syndrome;early experience;early onset;Early Onset Alzheimer Disease;Enrollment;environmental agent;experience;Functional Magnetic Resonance Imaging;Funding;Genes;Genetic Risk;Impaired cognition;indexing;interest;Investigation;Laos;life span;Life Style;lifestyle factors;Longitudinal Studies;Measures;mild cognitive impairment;Modeling;Nerve Degeneration;neuropathology;novel;Pathway interactions;Phenotype;Physical activity;physical conditioning;Plasma;Play;Population;Positron-Emission Tomography;pre-clinical;prevent;Production;protective factors;Psyche structure;Public Health;recruit;Reporting;Research;Research Design;resilience;response;Risk;Role;Science;sedentary lifestyle;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep Fragmentations;social engagement;Symptoms;tau Proteins;tau-1;Time;United States National Institutes of Health

PROJECT_TITLE: Lifestyle and Alzheimer's Disease In Down Syndrome

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: KUSHI, LAWRENCE H (contact)

PROJECT_TERMS: Adolescent and Young Adult;Adolescent and young adult cancer patients;Advocacy;Agreement;American Cancer Society;Ancillary Study;Area;Biometry;Budgets;California;Cancer Survivor;Cancer Survivorship;Caregivers;Clinical;clinical care;Committee Members;Committee Membership;Communication;Communities;Contracts;Dana-Farber Cancer Institute;Data;data acquisition;Data Analyses;data resource;Development;Disparate;Ensure;experience;Financial Hardship;Growth;Health;Healthcare;Hospitals;Individual;insight;Institution;Institutional Review Boards;interest;Leadership;Los Angeles;Malignant Neoplasms;Manuscripts;member;Methods;Michigan;Modification;North Carolina;organizational structure;patient engagement;Patients;Pediatric Hospitals;Population;Principal Investigator;programs;Provider;psychosocial;Publications;Quality of life;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Robin bird;Saint Jude Children's Research Hospital;Site;Source;Surveys;Survivors;synergism;timeline;Universities;Washington;Work

PROJECT_TITLE: Core A: Administrative Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative The metastasis of cancerous cells to distant and vital organs is responsible for approximately 90% of cancer mortalities, and it is clear that an important barrier to tumor progression and metastasis is the survival of cancer cells that are detached from the extracellular matrix (ECM). However, our understanding of the molecular mechanisms underlying the survival of ECM-detached cancer cells remains rudimentary. This proposal seeks to examine how a novel pathway involving RIPK1 and the degradation of mitochondria can restrict breast cancer progression.

PI_NAMEs: SCHAFER, ZACHARY T. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Address;Anchorage-Independent Growth;Anoikis;Antioxidants;Applications Grants;Biological;Biological Assay;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer Patient;cancer survival;Cancerous;Caspase;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Cessation of life;combat;Complex;Data;Death Rate;design;Development;Disease;Disseminated Malignant Neoplasm;Distant;Epithelial Cells;Exposure to;Extracellular Matrix;FDA approved;in vivo;insight;Integrins;intravenous injection;Investigation;Knowledge;Link;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;Mitochondria;Molecular;Molecular Analysis;mortality;Necrosis;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Nude Mice;Organ;Outcome;Pathway interactions;Patients;Phosphotransferases;Prognosis;programs;Protein Kinase Interaction;Proteins;Reactive Oxygen Species;Receptor Inhibition;Receptor Signaling;Receptor-Interacting Protein;Regulation;Role;Signal Transduction;Therapeutic;therapeutic development;Therapeutic Intervention;tumor;tumor progression;Tumor stage;tumorigenesis

PROJECT_TITLE: Mitophagy-Mediated Cell Death in Mammary Tumorigenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PHR: CORE NARRATIVE – Core B, Biostatistics and Data Harmonization Shared Resource  The Biostatistics and Data Harmonization Core will oversee and guide study design, data management and data analysis across all three P01 projects so that the scientific aims of each project are addressed using standardized, high-quality datasets and the most appropriate statistical methods. The Core will ensure that data are appropriate for the questions addressed, harmonized across source data systems to enhance comparability, and analyzed and interpreted with knowledge of strengths and limitations. This approach will maximize the potential impact of P01 findings to inform and improve healthcare for adolescent and young adult cancer survivors.

PI_NAMEs: QUESENBERRY, CHARLES  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;administrative database;Adolescent and Young Adult;Adolescent and young adult cancer patients;adverse outcome;Affect;Ambulatory Surgical Procedures;Biometry;Biostatistics Shared Resource;California;cancer care;Cancer Survivor;Caring;Clinical;clinical care;Clinical Data;clinical database;clinical encounter;cohort;Consultations;Continuity of Patient Care;cost effectiveness;Data;Data Analyses;data harmonization;Data Linkages;data management;Data Reporting;Data Set;Data Sources;design;Development;Disease;Emergency Situation;Ensure;Etiology;expectation;experience;Foundations;Goals;Guidelines;Health Planning;Health Resources;Healthcare;Healthcare Systems;Hospitalization;Human Resources;improved;inclusion criteria;Individual;Information Systems;insight;Integrated Health Care Systems;Investigation;Knowledge;Late Effects;Leadership;Link;Malignant Neoplasms;Measures;member;Methods;neoplasm registry;North Carolina;Outcome;Patient Outcomes Assessments;Patients;Phase;Population;population health;Predictive Factor;preference;Public Health;public health intervention;Registries;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;Resources;Risk Factors;Sampling;Selection Bias;Services;Source;Standardization;Statistical Methods;Surveys;Systematic Bias;Universities;Utah;Variant;Weight

PROJECT_TITLE: Core B: Biostatistics and Data Harmonization Shared Resource


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Rare Diseases

PHR: CORE NARRATIVE – Core C, Survey Shared Resource  The Survey Core of this P01 application will conduct a comprehensive patient survey on a wide range of recommended topics among AYA survivors with a broad set of cancer types, who are between 2 to 10 years from diagnosis, and from diverse racial and ethnic backgrounds. By surveying AYA cancer survivors directly about their care experiences and outcomes, we will collect high-quality patient-reported data that will be linked to healthcare data to ensure completion of project aims. Centralizing all survey activities in this Core will ensure efficiency and synergy in data collection across this program of research in AYA cancer survivors.

PI_NAMEs: CHUBAK, JESSICA  (contact)

PROJECT_TERMS: Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Age;aged;barrier to care;Biometry;Breast;California;cancer care;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer type;care delivery;Caring;Cervical;Characteristics;clinical care;cohort;Colorectal;Continuity of Patient Care;Data;Data Analyses;data cleaning;Data Collection;data harmonization;data quality;Data Reporting;Data Set;data sharing networks;Data Sources;design;Diagnosis;Electronic Health Record;Electronic Mail;Eligibility Determination;Employment;Enrollment;Ensure;Epidemiology;Ethnic Origin;evidence base;evidence based guidelines;experience;Family;Fertility;field survey;Financial Hardship;Funding;Future;Goals;Health;Health behavior;Health Resources;Health Services;Health Services Research;Healthcare;Healthcare Systems;Hodgkin Disease;improved;Incentives;Individual;Institutional Review Boards;Insurance;insurance claims;Internet;intervention delivery;Interview;Letters;leukemia;Link;Malignant Neoplasms;Manuscripts;Measures;Medical;Melanoma;Methods;neoplasm registry;Non-Hodgkin's Lymphoma;North Carolina;Online Systems;Outcome;Paper;Participant;Patient Care;Patient Outcomes Assessments;patient-clinician communication;Patients;pilot test;population health;population survey;Preparation;Procedures;programs;Psychology;Psychometrics;psychosocial;Publishing;quality assurance;racial diversity;Recommendation;recruit;Reporting;Reproduction;Research;Research Methodology;Research Personnel;Resource Sharing;Resources;Respondent;response;Sampling;Sarcoma;Site;Sociology;sound;Source;Specific qualifier value;success;Survey Methodology;Surveys;Survivors;Symptom Burden;synergism;System;Telephone;Testing;Thyroid Gland;Time;Universities;Work

PROJECT_TITLE: Core C: Survey Shared Resource Core


NIH_SPENDING_CATS: Aging;Biotechnology;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative:  The proposed research can help improve the diagnosis and treatment of hematopoietic diseases, particularly the blood and immune diseases associated with aging and TET2 mutations. It can also help improve bone marrow transplantation and develop new blood regeneration treatments that are independent of transplantation.

PI_NAMEs: LU, RONG  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;age related;Aging;Basic Science;Behavior;Blood;Bone marrow failure;Bone Marrow Transplantation;Cells;Diagnosis;Disease;Dysmyelopoietic Syndromes;Foundations;Genes;Hematological Disease;Hematopoietic;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;Heterogeneity;Human;Immune System Diseases;improved;Individual;Injury;Knowledge;leukemia;Maps;Medicine;Molecular;Molecular Profiling;Mus;Mutation;Myeloproliferative disease;Natural regeneration;novel;Organ;Organism;Pathogenesis;programs;Regulation;repaired;Research;self-renewal;single cell analysis;stem cell therapy;stem cells;Systems Biology;Technology;Therapeutic Uses;Tissues;Transplantation

PROJECT_TITLE: Investigating the heterogeneity and coordination of hematopoietic stem cells


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative Mapping brain-wide connectivity of neuronal types will provide a foundation for understanding the structures of non-human primate brains, but the scale of primate brains is challenging for many neuroanatomical techniques. Here we propose to optimize and develop barcode sequencing-based neuroanatomical techniques to achieve brain-wide, high-throughput, highly multiplexed mapping of axonal projections and synaptic connectivity of neuronal types at cellular resolution in primate brains. We will apply these techniques to generate an unprecedented multi-resolution map of brain-wide projections and synaptic inputs of neurons in the macaque visual cortex at cellular resolution.

PI_NAMEs: CHEN, XIAOYIN  (contact);KEBSCHULL, JUSTUS M;WICKERSHAM, IAN R

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Anatomy;Animals;Axon;Bar Codes;Behavioral;Brain;BRAIN initiative;Brain Mapping;Brain region;cell type;Cells;Censuses;Characteristics;Cognitive;Complement;Computer Models;connectome;Consumption;cost;Data;Data Set;design;Electron Microscopy;Equipment;extrastriate visual cortex;Foundations;Gene Expression;Goals;improved;in situ sequencing;Individual;Injections;Label;Laboratories;light microscopy;Link;Macaca;Maps;Messenger RNA;Methods;Microscopy;Mus;Neuroanatomy;neuronal cell body;Neurons;Neuropil;nonhuman primate;novel strategies;postsynaptic neurons;presynaptic neurons;Primates;Process;rabies viral tracing;rabies virus barcoding;Reagent;Resolution;RNA;RNA Processing;RNA Sequences;Rodent;scale up;Sindbis Virus;Speed;Structure;Synapses;Techniques;Testing;Time;transcriptomics;Tropism;Viral;Visual;Visual Cortex;Work

PROJECT_TITLE: BRAIN CONNECTS: Mapping brain-wide connectivity of neuronal types using barcoded connectomics


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Children with moderate to severe bilateral CP have poor upper extremity abilities and segmental trunk control deficits, limiting independent functional sitting. This study will compare the efficacy of a motorized Trunk-Support- Trainer (TruST) to engage children in play-oriented practice with skill progression with static trunk support . The TruST-intervention will inform clinicians whether such training may be a unique therapeutic solution for children with bilateral CP to acquire and improve independent functional sitting.

PI_NAMEs: AGRAWAL, SUNIL K. (contact);GORDON, ANDREW M.

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Activities of Daily Living;Address;Affect;arm;Bilateral;Brain Injuries;Cerebral Palsy;Child;Childhood;Classification;Clinic;clinical practice;comparative efficacy;cost;Data;dexterity;Education;effective therapy;Equilibrium;Equipment;evidence base;functional improvement;functional independence;Goals;Head;Health;Home;Impairment;improved;innovation;Intervention;Leisure Activities;Life Expectancy;Motor;motor learning;Movement;Musculoskeletal Equilibrium;Neuronal Plasticity;novel;Pelvis;Play;Postural adjustments;Posture;Rehabilitation therapy;Research;Robotics;Series;skills;System;technological innovation;Technology;Therapeutic;Training;Treatment Efficacy;Upper Extremity;Veins;Walking;Wheelchairs;Work

PROJECT_TITLE: Improving seated postural control and upper extremity function in bilateral CP with a robotic Trunk-Support-Trainer (TruST)


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICS

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Many pathogenic bacteria are notorious for surviving harsh environments, adapting to different niches in the human body, and developing tolerance to drug treatments, all examples of phenotypic plasticity. Cellular organizations, as a hallmark of cell phenotype, dictate the physiological state and fitness of bacteria, and unraveling the origins and consequences of its plasticity is key to understanding the survival, growth, adaption, and drug tolerance of pathogenic bacteria. Exploring the optimality principles for the cellular organization could help identify bottlenecking cellular processes that can serve as non-molecular-specific targets with minimal concerns of rising drug resistance.

PI_NAMEs: SI, FANGWEI  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Algorithms;antibiotic tolerance;Bacteria;Bacterial Infections;Behavior;Biological Process;Biomedical Engineering;Biophysics;Cell Death;Cell membrane;Cell Physiology;Cells;Cessation of life;Chemicals;Collaborations;Communities;Computer software;Crowding;Data Set;density;Drug resistance;Drug Tolerance;Environment;Escherichia coli;experimental study;fitness;Fostering;Goals;Growth;Hallmark Cell;Human body;human pathogen;Image Analysis;Knowledge;laboratory experience;Life;Membrane;Membrane Proteins;Microfluidic Microchips;model organism;Modeling;Molecular Biology;non-genetic;operation;Organism;Outcome;pathogen;pathogenic bacteria;Pharmacotherapy;Phenotype;physical model;physical property;Physics;Physiological;Physiology;Positioning Attribute;Protein Databases;Proteins;Pseudomonas aeruginosa;Publishing;Research;Testing;tool

PROJECT_TITLE: Gauging how the plasticity of cellular organizations dictates growth, death and adaptation in single bacterial cells


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Liver disease is an important health problem which may be caused or influenced by exposures to chemicals in the environment. To study this problem, this project establishes an integrative and collaborative research program, the Environmental Liver Disease Revolutionizing Innovative, Visionary Environmental Health Research Program (ELD-RIVER).

PI_NAMEs: CAVE, MATTHEW C (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Academia;Address;Adolescent;Adult;Affect;Animal Model;Area;Cardiovascular Diseases;Cessation of life;Chemical Exposure;Chemicals;Child;chronic liver disease;Cirrhosis;Collaborations;Data;Development;Diabetes Mellitus;diagnostic biomarker;disease registry;Endocrine;Environment;environmental chemical;Environmental Health;Epidemiologist;Exposure to;fatty liver disease;global health;Goals;Government Agencies;Health;Hepatocyte;human subject;Industry;innovation;Institution;Lipids;Liver;Liver diseases;Malignant neoplasm of liver;Medical Societies;Metabolism;Methods;multiple omics;National Institute of Environmental Health Sciences;next generation;Nutrient;Obesity;Physicians;Poison;Policies;Polychlorinated Biphenyls;Population;Practice Guidelines;programs;Reproducibility;Research;Resources;Scientist;sex;Strategic Planning;Time;Training and Education;translational goal;Transplantation;Vinyl Chloride;Vision;Work

PROJECT_TITLE: Environmental Liver Disease


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Immunotherapy;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study will investigate the role of cytotoxic T lymphocytes (CTLs) in the targeting of self-proteins in patients with rheumatoid arthritis (RA). We propose that this specialized type of killer cell is responsible for the initiation and maintenance of inflammation in a subset of patients with RA who have the most severe disease. These findings may lead to the development of new therapeutic strategies aimed at disrupting this disease- promoting pathway.

PI_NAMEs: ANDRADE, FELIPE  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Alleles;Antibodies;Antigen Presentation;antigen processing;Antigen Targeting;Antigen-Presenting Cells;Antigens;Arthritis;arthropathies;Autoantibodies;Autoantigens;Autoimmune;Autoimmunity;autoreactivity;B-Lymphocytes;Calcium;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cessation of life;chronic T-cell leukemia;citrullinated protein;Citrulline;Clonal Expansion;Clonality;Clone Cells;cohort;Complex;Cytolysis;Cytoplasmic Granules;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Disease;DNA Sequence Alteration;Enzymes;Epitopes;Etiology;Generations;Genetic;Goals;Granzyme;HLA-DRB1;Human;human model;Immune response;Immune Targeting;immunogenic;Inflammation;innovation;insight;Isoenzymes;Joints;Killer Cells;Knowledge;Laboratories;leukemia;Link;Lymphocyte;Maintenance;Mediating;Methods;Modeling;monocyte;Mutation;Natural Killer Cells;Neutropenia;neutrophil;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;patient subsets;Patients;perforin;Phenotype;preventive intervention;Process;Protein-arginine deiminase;Proteins;Publishing;Rheumatoid Arthritis;Role;Series;Serology;Shapes;Specificity;Stat3 protein;Subgroup;T-Cell Large Granular Lymphocyte;Technology;Testing;Therapeutic Intervention;Universities;Virginia;Work

PROJECT_TITLE: The role of cytotoxic T cells in rheumatoid arthritis pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Heart Disease;Congenital Structural Anomalies;Emergency Care;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Patient Safety;Pediatric;Rare Diseases;Stroke

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The goal of this project is to examine the feasibility and safety of administering hydrogen gas to patients suffering from cardiac arrest treated with emergency heart-lung bypass. Oxygen deprivation to the brain results in severe brain injury or death in more than 50% of these patients, and hydrogen may be a therapy to directly interrupt the culpable mechanisms of brain injury. If feasible and safe, hydrogen administration may improve outcomes in cardiac arrest, stroke, myocardial infarction, organ transplant, and sepsis, all pathologies in which ischemia-reperfusion injury plays a central role.

PI_NAMEs: KHEIR, JOHN NAGI (contact);SLEEPER, LYNN A

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: adjudication;Adult;Adverse effects;Agreement;Area;Biological Markers;Blinded;Blood flow;Boston;Brain;Brain Death;Brain Injuries;Cannulas;Cardiopulmonary Bypass;Cardiopulmonary Resuscitation;Caring;cell injury;Cellular Structures;Cephalic;chemical reduction;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically significant;community consultation;comorbidity;congenital heart abnormality;Creatinine;Critical Care;Data;Data Analyses;Decision Making;deprivation;Devices;Diatoms;Disease;Documentation;Education;efficacy study;Emergency Situation;empowerment;Enrollment;Ensure;Environment;experience;Family suidae;feasibility testing;Feedback;Foundations;Functional disorder;functional status;Gases;Goals;Graft Rejection;Heart Arrest;heart function;Hepatic;Hour;Hydrogen;Hypoxemia;Image;Impairment;improved;improved outcome;inclusion criteria;Informed Consent;Infrastructure;Inhalation;Injury;Injury to Kidney;Institutional Review Boards;Interruption;Ischemia;ischemic injury;Ischemic Stroke;Lead;Logistics;Magnetic Resonance Imaging;Manuals;manufacture;Measures;mechanical circulatory support;Mediator;meetings;Modeling;Myocardial Infarction;Myocarditis;Nature;Nervous System Physiology;Nervous System Trauma;Neurologic;Nose;open label;operation;Organ Transplantation;Oxygen;Participant;Pathology;Patients;Pediatric Hospitals;Phase;phase 3 study;Pilot Projects;Play;point of care;Population;pre-clinical;primary endpoint;Process;Protocols documentation;pulmonary function;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;Regulation;Renal function;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Research Design;Research Personnel;Rodent;Role;Safety;safety and feasibility;safety study;secondary endpoint;Seizures;Sepsis;Serious Adverse Event;Serum;severe injury;Site;Specific qualifier value;Stroke;Symptoms;Testing;Texas;Therapeutic Agents;Time;Translational Research;treatment as usual;treatment group;trial design;white matter injury;Work

PROJECT_TITLE: Multi-center, randomized, controlled trial of the feasibility and safety of inhaled hydrogen gas during ECPR


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Physical Activity;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise and related behaviors. This research will develop a mobile application that delivers personalized encouragement and data-driven health insights based upon patterns in blood sugar, exercise, mood, and sleep, to assist people with type 1 diabetes in exercising more frequently and confidently.

PI_NAMEs: ASH, GARRETT IGO (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adherence;Adult;Affect;Affective;American;attributable mortality;Bayesian Modeling;Behavior;Behavioral;biobehavior;Bioinformatics;Blood Glucose;blood glucose regulation;Cardiovascular Diseases;Cardiovascular system;Caring;Client;Clinical;Clinical Trials;Computer software;Consultations;Continuous Glucose Monitor;Data;data repository;Data Storage and Retrieval;Development;diabetes management;diabetes self-management;diaries;Diet;digital applications;dimension reduction;Early Intervention;Educational workshop;Electronics;Elements;Etiology;Evaluation;evidence base;Evidence based intervention;Exercise;exercise intervention;exercise prescription;Fatigue;Feasibility Studies;feasibility trial;Feedback;Foundations;Fright;Future;Generations;glycemic control;Goals;Grant;hazard;Health;Health behavior change;health goals;heuristics;Human;Hypertension;Hypoglycemia;improved;Informatics;innovation;insight;Instruction;Insulin;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Laboratories;Libraries;machine learning classification;Mathematics;Measures;Medical;Mentors;mHealth;mhealth interventions;middle age;mobile application;model development;Modeling;Modification;Monitor;Moods;mortality risk;Motivation;motivational enhancement therapy;novel;Obesity;Outcome;Participant;Patients;Pattern;Persons;pilot test;precision medicine;prevent;programs;Provider;psychosocial;Publishing;Recommendation;Reporting;Research;response;Safety;satisfaction;sedentary;Self Efficacy;skills;Sleep;symposium;Technology;Testing;Text;Text Messaging;therapy development;Time;tool;Training;Translating;United States National Institutes of Health;Waiting Lists;Work;Writing

PROJECT_TITLE: Informatics-Based Digital Application to Promote Safe Exercise in Middle-Aged Adults with Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Environmental factors that can be modified at community-scale, including air pollution and features of the built and natural environment, may affect the risk of developing diabetes. Better understanding of the relationship between environmental factors and diabetes will help in the development of cost-effective policies to protect public health and reduce health inequality—critical parts of the NIH mission. This study will investigate these relationships in Hispanic Community Health Study/Study of Latinos and help to understand the inter- relationship between development of diabetes and traffic-related air pollution, the neighborhood built environment, and the intensity and location of physical activity.

PI_NAMEs: KAUFMAN, JOEL DANIEL (contact)

PROJECT_TERMS: Accelerometer;Address;Adult;Affect;Air Pollutants;Air Pollution;Ancillary Study;Area;Benefits and Risks;Biological;built environment;Cardiovascular Diseases;Cause of Death;Characteristics;Clinical;clinical examination;Cluster Analysis;cohort;Cohort Studies;Communities;cost;cost effective;Data;Development;Diabetes Mellitus;diabetes risk;Diet;Dimensions;Direct Costs;Disparate;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Ethnic Origin;Exercise;Exposure to;Facilities and Administrative Costs;Funding;Genetic;Genetic Predisposition to Disease;Genomics;Genotype;glycemic control;Glycosylated hemoglobin A;Green space;Health;health disparity;Health Food;health inequalities;Heterogeneity;high risk population;Hispanic;Hispanic Community Health Study/Study of Latinos;Incidence;Individual;knowledge base;Latino Population;Link;Location;low socioeconomic status;Measurement;Measures;Meta-Analysis;Metabolic;Metabolic Diseases;metabolomics;meter;Methodology;metropolitan;Mission;Modeling;Modification;Monitor;mortality;multiple omics;Neighborhoods;Nitrogen Dioxide;Nitrogen Oxides;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome Measure;Ozone;Participant;Particulate Matter;Persons;Phenotype;Physical activity;Play;Policies;Pollution;Population;Prediabetes syndrome;Prevalence;protective factors;Psychosocial Factor;Public Health;Race;Relative Risks;Research;Resources;Respiratory Disease;Risk;Risk Factors;Risk Reduction;Role;Series;Socioeconomic Status;Source;traffic-related air pollution;United States National Institutes of Health;urban disparity;Urban Population;urban setting;Visceral;walkability

PROJECT_TITLE: SOLAir: Environmental Factors and Diabetes Development in Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Cell-cell communication plays a critical role in organ development and healing responses following injury and disease progression. Here, we employ an integrative approach of bioengineering tools, intracellular signaling reporters, and computational modeling to (1) study mechanisms that orchestrate paracrine- and mechanically induced migratory decisions in macrophages and (2) elucidate oxygen-dependent fibroblast activation and ECM remodeling via interactions with macrophages. These studies will contribute to our understanding of homeostatic macrophage-fibroblast crosstalk and lay the foundation for future studies on dysfunctional macrophage-fibroblast interactions.

PI_NAMEs: ZERVANTONAKIS, IOANNIS  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Address;Biomedical Engineering;Biosensor;Cell Communication;cell motility;cell type;Cells;Communication;Complex;Computer Models;Disease Progression;Engineering;Environment;Experimental Models;Extracellular Matrix;Fibroblasts;Foundations;Future;Homeostasis;Image;Injury;insight;intercellular communication;Knowledge;Macrophage;Measurement;mechanical force;mechanical signal;Mechanics;Microfluidic Microchips;microfluidic technology;Microfluidics;migration;Monitor;Multicellular Process;novel;organ growth;organ repair;Oxygen;paracrine;Physiological Processes;Play;Reporter;Research;response;Role;Signal Transduction;spatiotemporal;Time;Tissue Engineering;Tissues;tool

PROJECT_TITLE: Macrophage-Fibroblast Communication in Cell Migration and Extracellular Matrix Remodeling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: Project Narrative: In patients with urinary stone disease, several knowledge gaps persist regarding the impact of fluid therapy in preventing stone recurrence, and the optimal care after insertion of a ureteral stent (a thin tube inserted into the ureter to prevent obstruction of the urine flow from the kidney). This application will address these gaps by assessing the effectiveness and safety of new behavioral strategies to increase urine fluid intake, and evaluating factors contributing to discomfort following stent insertion, with the ultimate goal of improving patient care.

PI_NAMEs: HARPER, JONATHAN D. (contact);WESSELLS, HUNTER

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;arm;associated symptom;Behavior Therapy;Behavioral;Biological;Blood;Caring;Child;Childhood;Clinic;Clinical;clinical care;clinical center;Clinical Research;cohort;Collection;Communities;cost;COVID-19;COVID-19 pandemic;Data;Data Collection;Deposition;design;Disease;Effectiveness;effectiveness evaluation;Endocrinologist;Enrollment;Ensure;evaluation/testing;Event;Excision;experience;financial incentive;Fluid Therapy;follow-up;Foundations;Funding;Future;Goals;Health;health care service utilization;Hydration status;improved;Individual;innovation;insight;Institution;Intake;Intervention;Interview;Investigation;Kidney;Kidney Calculi;Knowledge;Lifting;Liquid substance;Lived experience;Manuscripts;Measures;Medical;Medicine;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;observational cohort study;Obstruction;Operative Surgical Procedures;Output;outreach;Pain;Participant;participant enrollment;Patient Care;Patient Recruitments;Patient Self-Report;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perioperative complication;Philadelphia;Plasma;Prevalence;prevent;Prevention;primary endpoint;Problem Solving;Procedures;programs;prospective;Prospective, cohort study;Psychosocial Assessment and Care;Public Health;Publications;Questionnaires;radiologist;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Recurrent disease;Regimen;Reporting;repository;Research;Research Design;Research Institute;Research Personnel;Resources;response;Safety;Sampling;Science;Scientist;Sensory;Serum;Societies;Stents;Structure;success;Symptoms;Texas;therapy design;Thinness;Time;Touch sensation;treatment arm;Tube;Universities;Ureter;Ureteroscopy;urinary;Urinary Calculi;Urine;urologic;Urologist;Variant;Visit;Washington;Water;Whole Blood

PROJECT_TITLE: UW USDRN Clinical Center


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Childhood Obesity;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Children with Down syndrome are disproportionately affected by the obesity epidemic, presenting a prevention challenge that is currently unmet. For toddlers and preschoolers with Down syndrome, this project examines how motor skills development, feeding abilities, co-occurring conditions, dietary intake, and the family context provide protection or risks for overweight/obesity. The overarching goal of this project is to identify targets for effective prevention in early childhood when such efforts may enhance downstream health outcomes for those with Down syndrome.

PI_NAMEs: DAUNHAUER, LISA ANN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 6 year old;Adult;Affect;Age;aged;aspirate;Attention;Birth;Body Weight;Caregivers;caregiving;Child;Childhood;Chronology;Clinical Data;Collection;Congenital Heart Defects;Data;Development;Diagnosis;Diet;dietary;Dietary intake;Disease;Down's Syndrome;early childhood;Early identification;Energy Intake;Enrollment;Ensure;experience;Family;Family dynamics;feeding;follow-up;foot;General Population;Goals;Growth;Health;Height;high risk;high risk population;Hypothyroidism;improved;Individual;individual variation;Intake;Intellectual functioning disability;Knowledge;Learning;Life Expectancy;life span;longitudinal design;Macronutrients Nutrition;Measures;Medical;Medical History;Modeling;Motor;Motor Skills;neurogenetics;non-alcoholic fatty liver disease;nutrition;obese person;Obesity;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;Obstructive Sleep Apnea;Outcome;Overweight;overweight child;Participant;Personal Satisfaction;Persons;Phenotype;Physical activity;Prevalence;Prevention;primary caregiver;Probability;prospective;protective factors;Proxy;recruit;Reporting;Research;Research Personnel;resilience factor;Risk;Risk Factors;Risk Reduction;Sampling;Science;Seasons;sex;Site;skill acquisition;Sleep;social;Time;Toddler;Underserved Population;United States National Institutes of Health;Visit;Walking;Weight;Weight Gain

PROJECT_TITLE: Obesity Prevention Targets for Down Syndrome

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Nearly 40% of individuals with bipolar disorder (BD) will develop co-occurring alcohol use disorder (AUD+BD), associated with significantly worse clinical course, poorer treatment response, and increased risk for suicide relative to AUD or BD alone. Dysfunctional reward brain circuitry is a core feature of both AUD and BD yet remains largely unexplored in AUD+BD. The proposed multimodal neuroimaging study seeks to identify neurobiological targets for improving treatment and preventative interventions for AUD+BD by defining reward brain circuitry structure and function among sets of parents with AUD+BD and their unaffected adolescent offspring (dyads) relative to dyads defined by parental AUD alone.

PI_NAMEs: MELLICK, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Adolescence;adolescent offspring;Adult;Affect;age group;alcohol abuse therapy;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Award;Biological Markers;biomarker identification;Bipolar Disorder;Brain;brain based;brain circuitry;brain dysfunction;brain reward regions;career;career development;Child;Clinical;clinical application;Clinical Psychology;Clinical Research;Clinical Treatment;cognitive control;Consultations;Data;Decision Making;design;Development;Development Plans;developmental neurobiology;Diffusion;endophenotype;Etiology;Exhibits;experience;Family;Functional Magnetic Resonance Imaging;Future;Goals;Heritability;high risk;Image;Imaging Techniques;improved;Individual;interest;Internal Capsule;Investigation;Knowledge;Limb structure;Measurement;Measures;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mood Disorders;MRI Scans;multimodal neuroimaging;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;neuroimaging;offspring;Parents;Pathway interactions;Patient Self-Report;Patients;Population;Prefrontal Cortex;preventive intervention;Psychopathology;Radiation;Reading;Research;research and development;Research Design;Research Methodology;Research Personnel;reward circuitry;Rewards;Series;skills;social;statistics;Structure;Substance Use Disorder;suicidal risk;Testing;Training;treatment response;trend;Ventral Striatum;white matter

PROJECT_TITLE: An investigation of reward brain circuitry structure and function in individuals with co-occurring alcohol use disorder and bipolar disorder and their unaffected offspring

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Research today provides hope and the foundation for new treatments and cures for tomorrow. Specialized education and training in clinical and translational sciences is needed to develop investigators capable of bridging the gap between the lab, the clinic, and disciplinary boundaries and to accelerate the delivery of innovations to all communities. The goal of this new Ohio State University Center for Clinical and Translational Science predoctoral T32 training program is to leverage the large, collaborative and multidisciplinary research environment of Ohio State to recruit, train and mentor a diverse cohort of trainees from a wide variety of graduate programs and colleges to become the next generation of clinical and translational science leaders who will lead high impact research that is rigorous, inclusive, ethical and intentional to achieve health equity.

PI_NAMEs: BUMGARDNER, GINNY L (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Ohio;pre-doctoral;Universities

PROJECT_TITLE: CTSA Predoctoral T32 at the Ohio State University


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Mitochondrial cardiomyopathies, which frequently affect Complex I of the electron transport chain, are typically pediatric diseases associated with significant morbidity and mortality. Yet, patients often live months to years with often severe cardiac dysfunction, suggesting that there are compensatory mechanisms that allows for energy production despite Complex I dysfunction. Here, I investigate a newly described Complex I-dependent mechanism that may help preserve energy production.

PI_NAMEs: CVRTI, SANDRA HYUNJOO (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adult;Affect;Antioxidants;Apoptosis;ATP Synthesis Pathway;Bioenergetics;Biological Assay;calcium uniporter;cancer cell;Cardiac;Cardiomyopathies;Characteristics;Child;Childhood;clinically relevant;Co-Immunoprecipitations;Compensation;Complex;Consumption;Cytoprotection;Data;Developmental Delay Disorders;Disease;Electron Transport;Electrons;Equilibrium;extend lifespan;fatty acid metabolism;fatty acid oxidation;Flow Cytometry;Functional disorder;Heart Diseases;Homeostasis;Hydroxysteroids;Hypoxia;Impairment;Inborn Errors of Metabolism;interest;Live Birth;Malignant Neoplasms;Measures;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial cardiomyopathies;Mitochondrial complex I deficiency;Mitochondrial Diseases;Mitochondrial Proteins;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Weakness;Mutation;Myocardial dysfunction;NADH;NADH dehydrogenase (ubiquinone);Nerve Degeneration;new therapeutic target;novel;Nuclear;Organ;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidoreductase;Pathologic;Pathway interactions;Patients;peroxiredoxin;Physiological;Physiology;Play;PRDX3 peroxidase;preservation;Production;protein degradation;Proteins;Proteome;Proteomics;Publishing;Reaction;Reactive Oxygen Species;Regulation;Role;Signaling Molecule;Source;Steroids;Superoxides;Symptoms;System;Testing;transcriptomics;Transfer RNA;Ubiquinone;Up-Regulation;Work

PROJECT_TITLE: A novel mechanism of mitochondrial protein turnover in Complex I deficient mitochondrial cardiomyopathy


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Hypertension has long been recognized as a major risk factor for cardiovascular diseases, including coronary artery disease, heart failure and stroke, and for ESRD. In the southeastern United States, and especially in Mississippi, cardiovascular and renal diseases occur much more frequently than in the rest of the country. The objective of the multidisciplinary Hypertension and Cardiorenal Diseases Research (HCDR) Training Program is to recruit, train, and mentor pre-doctoral and postdoctoral students in cardiovascular and renal research so that they become the next generation of researchers in this field.

PI_NAMEs: GRANGER, JOEY P. (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Cardiorenal syndrome;Hypertension;Research Training;Training Programs

PROJECT_TITLE: Hypertension and Cardiorenal Diseases Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Osteoporosis;Precision Medicine;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: 8. Project Narrative Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital admissions exceeding those of heart attacks, strokes and breast cancer combined. Current treatment options do not account for differences between age-related and estrogen deficiency related osteoporosis, because of the need for bone biopsies for determination. This study will establish a paradigm-shifting individualized treatment protocol for age- related osteoporosis and a non-invasive method for its determination, thereby reducing the major health problems and enormous burden on society and the elderly related to this disease.

PI_NAMEs: MALLUCHE, HARTMUT H (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Achievement;Adult;Affect;Age;age related;Age-Related Bone Loss;Age-Related Osteoporosis;aging population;Alendronate;American;Anabolic Agents;Biological Assay;Biopsy;bisphosphonate;Blood;bone;Bone Density;bone loss;Bone marrow biopsy;bone mass;Bone Resorption;bone turnover;burden of illness;carboxylate;comparison group;Complement;Data;design;Diagnosis;Disease;Dual-Energy X-Ray Absorptiometry;Effectiveness;Elderly;Enrollment;Estrogen deficiency;Familiarity;Forteo;Fracture;Health;Hematologist;Histology;Hospitalization;improved;individualized medicine;Life;Malignant Breast Neoplasm;Measurement;Measures;Medicare;Menopause;Methods;mortality;Myocardial Infarction;normal aging;novel;Osteocalcin;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Patients;personalized approach;Pharmaceutical Preparations;Physicians;Population;precision medicine;prospective;Quality of life;Randomized;Regimen;Serum;Societies;Special needs;standard of care;Stroke;success;Techniques;Testing;Therapeutic;tool;Training;Treatment Protocols;Validation;Woman;women patients

PROJECT_TITLE: Novel precision medicine approach to treatment of osteoporosis based on bone turnover


NIH_SPENDING_CATS: Cancer;Genetics;Pediatric

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative The faithful segregation of genetic material by the mitotic spindle to daughter cells is essential for the survival of an organism. Critical to this process are the many molecular motors that facilitate spindle organization and regulate the dynamics of the microtubules in the spindle. This proposal will define mechanisms that control motor activity and define how distinct protein- protein interaction networks impact spindle morphogenesis and help cells maintain genomic integrity.

PI_NAMEs: WALCZAK, CLAIRE E (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Aneuploidy;Binding;Biochemical;Biological Assay;Biological Models;cancer cell;Cell Death;cell type;Cells;Centrosome;Chromosome Segregation;Chromosomes;Complement;Congenital Abnormality;daughter cell;Defect;DNA Repair;Ensure;Genetic Materials;genome integrity;Goals;Image;Individual;insight;interest;Lead;Meiosis;Microtubules;Mitosis;Mitotic;Mitotic spindle;Modeling;Molecular;Molecular Motors;Morphogenesis;Motor;Motor Activity;motor control;Normal Cell;Organism;Outcome Study;overexpression;Pathway interactions;Play;Ploidies;Process;protein function;protein protein interaction;Proteins;Role;segregation;Structure;targeted treatment;therapeutic development;tumorigenesis;Variant

PROJECT_TITLE: Mechanisms of Mitotic Fidelity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The goal of this proposed research is to collect pilot data to test the hypothesis that treatment with a novel form of closed-loop digital meditation (MediTrain) will lead to a greater magnitude of gains in cognitive abilities in patients with mild cognitive impairment (MCI), compared to OA without cognitive impairment, and will lead to improvements in quantitative measures of sleep.

PI_NAMEs: WALSH, CHRISTINE MAIREAD;ZIEGLER, DAVID A (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: Affect;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Blood;Brain;Clinical Markers;Cognition;Cognitive;cognitive ability;Cognitive deficits;Cognitive remediation;cognitive reserve;cognitive task;cohort;Controlled Clinical Trials;Coupled;Data;Dementia;Diagnosis;digital;efficacy evaluation;Exhibits;Foundations;functional decline;Future;Goals;Home;Impaired cognition;improved;improvement on sleep;indexing;Individual;Intervention;Length;magnetic resonance imaging/electroencephalography;Measures;Meditation;mild cognitive impairment;Monitor;neuroimaging;neuropathology;non rapid eye movement;normal aging;novel;older adult;Outcome Measure;Participant;Patients;Pattern;Personal Satisfaction;Physiological;Pilot Projects;Population;pre-clinical;prevent;Randomized, Controlled Trials;Reaction Time;Regulation;Reporting;Research;Retrospective Studies;Risk;Risk Factors;Sampling;Severities;Sleep;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;Stage III Sleep;Stress;stress reactivity;stress reduction;Subgroup;telomere;Testing;Therapeutic;Thinness;Time;tool;Work;young adult

PROJECT_TITLE: A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Genetics;Human Genome;Lung

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Chronic obstructive pulmonary disease (COPD) affects between 5 and 7% percent of the adult US population. Most mutations associated with COPD change regions of the genome that do not code for protein but are transcribed into RNA. By combining RNA sequencing analysis of lungs from COPD patients with novel RNA structure probing technologies to identify functional RNA structures in COPD associated genes, we will illuminate new causative features of COPD and, over longer periods, inspire new RNA-based therapeutic strategies.

PI_NAMEs: LAEDERACH, ALAIN T (contact);WEEKS, KEVIN M

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;5' Untranslated Regions;Adenosine;Adopted;Adult;Affect;Alleles;Ally;alpha 1-Antitrypsin;Alternative Splicing;Area;Base Pairing;Binding Proteins;Biological;Biological Assay;Blood;Candidate Disease Gene;Cations;Cell Line;Cells;Charge;Chemicals;Chemistry;Chronic Obstructive Pulmonary Disease;clinically relevant;Code;Collection;Complex;Coupled;Data;design;Development;Disease;disorder risk;Distal;Environmental Risk Factor;Etiology;Event;Exhibits;Exons;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;genome wide association study;Human;infancy;Introns;Luciferases;Lung;Lung Diseases;Maps;Measures;Mediating;Messenger RNA;mRNA Precursor;mRNA Stability;mRNA Translation;Mutation;new technology;novel;Oligonucleotides;Open Reading Frames;Patients;Play;Polyadenylation;Population;Positioning Attribute;Post-Transcriptional Regulation;programs;protein expression;Protein Isoforms;Proteins;Quantitative Trait Loci;Reporter;Research;response;Ribosomes;RNA;RNA Probes;RNA Sequences;RNA Splicing;RNA-targeting therapy;Role;Sampling;Single Nucleotide Polymorphism;Single Nucleotide Polymorphism Map;Site;small molecule;Smoker;Smoking;Structure;technological innovation;Technology;therapeutic RNA;three-dimensional modeling;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;translation assay;translational impact;Translations;United States;Untranslated Regions;Untranslated RNA;vaping;Work

PROJECT_TITLE: Non-coding RNA structure change in Chronic Obstructive Pulmonary Disease

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Genetics;Hematology;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Dot1 and COMPASS/MLL1 histone lysine methyltransferases play essential roles in gene regulation and are deregulated in leukemias. In this application, we propose to use structural and functional approaches to elucidate the intricate mechanisms that underlie Dot1 and COMPASS/MLL1 regulation. These novel mechanistic insights will open new avenues towards therapies based on the epigenetic regulation of Dot1 and COMPASS/MLL1 activity.

PI_NAMEs: ARMACHE, KARIM JEAN (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;African Trypanosomiasis;Amino Acids;Binding;Biochemical;Biological Assay;Biological Models;Biological Process;Biology;Biophysics;Cell Culture Techniques;Cell Cycle Regulation;Cells;Cellular biology;Chagas Disease;chemical group;Chemicals;Chromatin;Chromatin Structure;comparative;Complex;Coupled;Cryoelectron Microscopy;Data;Dependence;Deposition;Development;Disease;DNA Repair;effective therapy;Ensure;Enzymes;Epigenetic Process;epigenetic regulation;Family;fighting;Gene Expression;Gene Expression Regulation;Genetic Recombination;Genetic Transcription;Histone Acetylation;histone acetyltransferase;Histone H3;Histone H4;histone methyltransferase;histone modification;Histone-Lysine N-Methyltransferase;Histones;Homologous Gene;Human;human pathogen;Immune system;improved;in vivo;inhibitor;insight;leukemia;Libraries;Link;Lysine;Malignant Neoplasms;Mammals;Mediating;Methods;Methylation;Methyltransferase;MLL gene;Modeling;Modification;Molecular Conformation;Mutate;Mutation Analysis;novel;novel strategies;novel therapeutics;Nucleosomes;Organism;Output;Play;Post-Translational Protein Processing;Post-Translational Regulation;Process;Proliferating;Property;reconstitution;Regulation;repaired;Resolution;RNA Polymerase II;Role;Saccharomycetales;Science;Specificity;Structure;System;Testing;Therapeutic;Transcription Elongation;Trypanosoma;Ubiquitination;Variant;Work;Yeasts

PROJECT_TITLE: Epigenetic mechanisms of regulation of histone lysine methyltransferases involved in leukemia

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: The proposed research is relevant to the public health because obesity, which is increasing in prevalence worldwide, represents a major national cost measured by both patient quality of life and economic burden. One under explored areas in obesity-related pathophysiology changes is the defects in mucosal innate immunity as we have previously shown, using Paneth cells as a proof-of-concept. Identifying the causes of how obesogenic diet reduces Paneth cell function will provide insight into the development of intervention strategies for diseases of which Paneth cells play a critical role, such as inflammatory bowel disease, graft versus host disease, and gut infection. Our preliminary data suggests that diet-induced obesity (due to western diet [WD] consumption) leads to Paneth cell dysfunction in both humans and mice by activating FXR signaling in the intestinal epithelium and myeloid cells. Upon conclusion, we will establish how dietary fructose (a key ingredient in WD) triggers Paneth cell defects, and determine the mechanisms by which Paneth cells themselves and intestinal stem cells repair defective Paneth cells in the context of long-term WD/HFrD consumption. Our data will help design intervention strategies for obese patients with Paneth cell defects.

PI_NAMEs: LIU, TA-CHIANG  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Abnormal Cell;Address;Affect;Area;base;Behavior;Bile Acids;Catabolism;CD11 Antigens;Cell Count;Cell Culture System;Cell Differentiation process;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Cellular Stress;cellular targeting;Clinic;Clinical;cohort;Consumption;Cost Measures;Data;Defect;Deoxycholic Acid;Diet;diet-induced obesity;dietary;Dietary Component;Disease;Economic Burden;endoplasmic reticulum stress;Enterocytes;Environmental Risk Factor;Epigenetic Process;epigenetic profiling;epigenetic regulation;Epithelial Cells;Exposure to;farnesoid X-activated receptor;Fatty acid glycerol esters;Fructose;Functional disorder;General Population;Genes;Goals;graft vs host disease;gut inflammation;High Fat Diet;Homeostasis;Human;ileum;impaired capacity;In Vitro;in vivo;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;Injury;innovation;insight;Interferon Activation;Interferon Type I;Intervention;intestinal epithelium;Intestines;Ketohexokinase;Knockout Mice;Knowledge;life span;Link;Mediating;Metabolic;Metabolism;microbiota;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mucous Membrane;Mus;Myeloid Cells;Natural Immunity;Natural regeneration;novel;novel therapeutics;obese patients;Obesity;obesogenic;Organoids;Overweight;Paneth Cells;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Play;Prevalence;prevent;Process;progenitor;programs;Public Health;Quality of life;receptor;Receptor Activation;Receptor Signaling;Reducing diet;repaired;Reporter;Reporting;Repression;Research;Risk;Role;sensor;Severities;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Small Intestines;stem cell differentiation;stem cell function;stem cell homeostasis;stem cells;Techniques;Testing;therapeutic target;therapy design;therapy development;transcriptomic profiling;transcriptomics;Translating;trial design;type I interferon receptor;Unhealthy Diet;western diet;Wild Type Mouse

PROJECT_TITLE: Dietary modulation of Paneth cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-P(03)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: CLEAR SCIENTIFIC, LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Fentanyl overdose is an epidemic, responsible for over 73,000 deaths annually in the US, and the standard of care, naloxone, is not sufficient. The proposed work addresses the urgent need for a therapeutic with a different mechanism of action, one that rapidly deactivates and removes fentanyl from the body. Such a therapeutic would save lives, improve patient outcomes, and relieve burden on already strained hospital resources.

PI_NAMEs: LI, XINHUA  (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Animal Model;Antidotes;Binding;Blood Circulation;Brain;Canis familiaris;carfentanil;Central Nervous System;Cessation of life;Clinical;Clinical Trials;Complex;Cyclic GMP;Data;Dose;Drug Interactions;Drug Metabolic Detoxication;drug of abuse;Drug usage;Epidemic;Excretory function;Fentanyl;fentanyl overdose;first-in-human;Formulation;Funding;Glomerular Filtration Rate;Goals;Half-Life;Hospitals;Human;Human body;improved;Induction of neuromuscular blockade;Injections;Intoxication;Intramuscular;Intramuscular Injections;Intranasal Administration;Intravenous;intravenous injection;Kidney;medication for opioid use disorder;Metabolic Clearance Rate;Methamphetamine;Modeling;mouse model;mu opioid receptors;Muscle Rigidity;Naloxone;naloxone dosing;nonhuman primate;Opioid;opioid overdose;opioid use disorder;opioid withdrawal;Organ;Overdose;overdose death;Patient-Focused Outcomes;Performance;Persons;Pharmaceutical Preparations;Phase;Phase Ia Clinical Trial;Phase Ib Clinical Trial;Plasma;pre-Investigational New Drug meeting;prevent;Probability;Rattus;Resources;Respiration;Route;Safety;Site;standard of care;success;synthetic opioid;Therapeutic;Therapeutic Agents;Time;Tissues;Toxicology;Urine;Withdrawal;Work

PROJECT_TITLE: A Therapeutic Agent to Lower the Level of Synthetic Opioids in the Body

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Patient Safety;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Uterine fibroids are the most common reason women undergo major surgery, with 30,000 myomectomies and 200,000 hysterectomies attributed to fibroids each year. The annual cost of care for women with fibroids is up to $34 billion with the largest burden of this expense (up to $17 billion) due to lost work and disability following fibroid surgery. In this clinical trial, we will evaluate the safety and efficacy of a new oral medication for fibroids that can decrease the large economic and social burden of fibroid surgeries and allow women to select a treatment option that avoids procedural risks and prolonged recovery time.

PI_NAMEs: HUANG, ALISON ;JACOBY, VANESSA  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Accounting;Adverse effects;Adverse event;adverse pregnancy outcome;Age;Aromatase;Aromatase Inhibitors;autocrine;Back;Biological;black women;Blinded;care costs;Caring;Cells;Clinical;Clinical Data;clinical outcome assessment;Clinical Research;Clinical Trials;Control Groups;Data;Development;disability;Disease;Dose;Drug usage;Economics;efficacy evaluation;Enrollment;Enzymes;Estrogens;ethnic diversity;FDA approved;Fibroid Tumor;follow-up;Follow-Up Studies;Functional disorder;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Growth;Hemorrhage;Hormonal;Hormone Antagonists;hormone therapy;Hormone use;Hormones;Hot flushes;Hypertension;Hysterectomy;improved;Infertility;Intestines;Letrozole;Long-Term Effects;Mediating;Medical;Menopause;novel;novel therapeutics;open label;Operative Surgical Procedures;Oral;Outcome;Ovarian;Ovarian hormone;Ovary;paracrine;Participant;Patients;Pelvic Pain;Pelvis;Pharmaceutical Preparations;Phase;placebo controlled trial;Placebos;Population;Population Heterogeneity;Postoperative Period;preference;Premenopause;pressure;Procedures;Production;Progestins;Quality of life;Questionnaires;racial diversity;Randomized;randomized placebo controlled trial;Recovery;reduce symptoms;Reporting;Risk;Safety;safety assessment;Serum;side effect;Smooth Muscle Tumor;social;Source;symptomatic improvement;Symptoms;Testing;Time;tumor;ultrasound;Uncontrolled Study;urinary;Uterine Fibroids;Uterine myomectomy;Uterus;White Women;Woman;Work

PROJECT_TITLE: Letrozole for Treatment of Uterine Fibroids: A randomized, placebo-controlled trial

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Recently, we showed that inhibition of RAGE significantly slowed glioblastoma tumor growth and invasion, one of the most fatal cancers with an average survival of less than 2 years after therapy. Inspired by this data, we propose to develop drugs that selectively inhibit the activity of RAGE in glioblastoma tumors. If successful, our studies will result in the development of a novel therapy for not only glioblastoma, but potentially for other cancers where RAGE is important for tumor growth and invasion.

PI_NAMEs: BADIE, BEHNAM  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Address;Alzheimer's disease patient;anti-tumor immune response;Attenuated;blood-brain barrier crossing;Cells;Chronic;Clinical Trials;Combined Modality Therapy;cytokine;Data;Development;Diagnosis;Dose;Down-Regulation;Effector Cell;Endothelial Cells;exhaust;exhaustion;Functional disorder;Future;Genetic;Glioblastoma;Glioma;glycation;Goals;Growth;Heterogeneity;Human;Immune;immune checkpoint blockade;Immune response;Immunoglobulins;Immunologics;Immunotherapy;improved;Infiltration;Inflammation;Inflammatory;inflammatory milieu;inhibitor;Invaded;Knockout Mice;Ligands;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;member;Membrane;Mesenchymal;Modeling;Molecular;Mus;novel;novel strategies;novel therapeutics;Oncogenic;oxidation;Pathway interactions;Patients;Pattern recognition receptor;permissiveness;Pharmaceutical Preparations;preclinical study;Process;programmed cell death protein 1;Proteins;Radiation therapy;receptor;Receptor Activation;receptor for advanced glycation endproducts;Receptor Inhibition;Regimen;Reporting;Resistance;resistance mechanism;response;Role;S100A9 gene;Secondary to;Signal Pathway;Signal Transduction;small molecule;success;synergism;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;therapy resistant;transcription factor;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;WNT Signaling Pathway

PROJECT_TITLE: Improving Glioma Immunotherapy Efficacy by Regulating Tumor Inflammation

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]