NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative P. falciparum malaria is a significant cause of morbidity and mortality worldwide. Antibody responses against the highly conserved, uncharacterized P. falciparum protein PF3D7_1136200 are correlated with protection from symptomatic disease. To further explore PF3D7_1136200 as a vaccine candidate, this project will study the role of PF3D7_1136200 in parasite biology and determine which protein domains are the main target of protective immune responses.

PI_NAMEs: GARZA, ROLANDO  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 5 year old;acquired immunity;Affect;Antibodies;Antibody Response;Antibody Specificity;Antibody-mediated protection;Antigens;Area;asexual;B-Lymphocytes;Biological Assay;Biology;Blood;burden of illness;Cessation of life;Characteristics;Child;Chronic;Circulation;cohort;Combined Vaccines;Data;design;Development;Disease;disorder risk;Erythrocytes;experience;Exposure to;Falciparum Malaria;Fluorescence-Activated Cell Sorting;Generations;Genetic;Goals;Growth;Human;Immune Plasma;Immune response;Immunity;Immunofluorescence Immunologic;immunogenic;immunogenicity;In Vitro;Individual;Infection;insight;Invaded;knock-down;Knock-out;Life Cycle Stages;Malaria;Malaria Vaccines;Maps;Mediating;Monoclonal Antibodies;Morbidity - disease rate;mortality;mortality risk;novel;novel vaccines;parasite invasion;Parasites;Parasitology;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Play;Population;Populations at Risk;Positioning Attribute;Predisposition;Protein Region;Proteins;Public Health;response;Reverse engineering;Role;Sampling;Site;Stains;Survival Analysis;Tertiary Protein Structure;Testing;transmission process;Uganda;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine discovery;vaccine efficacy;vaccine strategy;vaccine trial;Vaccines;Western Blotting

PROJECT_TITLE: Analyzing the function and antibody-mediated inhibition of the malaria vaccine candidate PF3D7_1136200

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Precision Medicine;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The main goal of this project is to develop and validate a rapid diagnostic platform capable of performing antimicrobial susceptibility testing of Neisseria gonorrhoeae (NG) using molecular RNA levels on a programmable microfluidic single-cell analysis platform.

PI_NAMEs: WANG, TZA-HUEI JEFF  (contact);YANG, SAMUEL

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Adoption;Agreement;Anti-microbial susceptibility;antimicrobial;Antimicrobial Resistance;Azithromycin;Baltimore;Biological;Biological Assay;Case Study;Ceftriaxone;Cells;Centers for Disease Control and Prevention (U.S.);Ciprofloxacin;Cities;Classification;Clinic;Clinical;clinical diagnosis;clinically actionable;clinically relevant;Color;Companions;Consumption;Coupled;Data;Derivation procedure;design;Detection;Development;Diagnosis;diagnostic platform;Disease;Drug resistance;effective therapy;Encapsulated;Engineering;Evaluation;Fluorescence Spectroscopy;Foundations;Genetic Transcription;Genitourinary system;Goals;Gonorrhea;Growth;Health;Health Policy;Hour;improved;Incubated;Individual;Infection;instrument;laboratory facility;Lighting;Machine Learning;Marker Discovery;Measures;Messenger RNA;Methods;Microfluidic Microchips;Microfluidics;Molecular;Neisseria gonorrhoeae;Nucleic Acid Amplification Tests;Performance;personalized medicine;Phenotype;Phylogenetic Analysis;precision medicine;Predisposition;prospective;Public Health;Publishing;Rapid diagnostics;Recommendation;Reporting;Reproductive Health;research clinical testing;Resistance;Resistance development;resistance mechanism;Resolution;response;RNA;routine practice;Sampling;Sexual Health;Sexually Transmitted Diseases;single cell analysis;single molecule;Specimen;spectroscope;Temperature;Testing;Time;Transcript;transcriptomic profiling;transcriptomics;treatment guidelines;Validation;validation studies

PROJECT_TITLE: Single-cell based diagnostic platform with single-molecular transcriptional response profiling for rapid phenotypic antimicrobial susceptibility testing of gonorrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE This application seeks funding for a non-profit seminar and conference that will bring together a diverse group of scientists, trainees, clinicians, and industry leaders to present and discuss their unpublished research on the role of Fibroblast Growth Factor (FGF) signaling in human health and disease. FGF signaling plays fundamental roles in tissue development and homeostasis, and its dysregulation results in a wide-range of human diseases that include congenital disorders of craniofacial complex and skeleton, metabolic diseases, and cancer. By highlighting innovative research and promoting multidisciplinary interactions in the field of FGF signaling, this conference will advance our knowledge of FGF-related disease and accelerate development of targeted therapies.

PI_NAMEs: MERRILL, AMY E (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Attention;autocrine;Award;Biology;Cancer Biology;career;career development;Cell Communication;Cell membrane;Cells;clinical application;Clinical Trials;Collaborations;Complex;Congenital Abnormality;Congenital Disorders;craniofacial;craniofacial complex;Dedications;Development;Diabetes Mellitus;Digestive System Disorders;Discipline;Disease;Educational workshop;Embryonic Development;Endocrine;Ethnic Origin;Event;Feedback;Female;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Financial Support;forging;Fostering;frontier;Funding;Future Generations;Gender;Genetic Diseases;Geography;Germ Layers;Goals;Health;Healthcare;Homeostasis;Hour;Human;human disease;Industrialization;Industry;Inflammatory;inhibitor;innovation;insight;interest;International;Knowledge;Ligands;Malignant Neoplasms;meetings;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;multidisciplinary;Musculoskeletal System;Natural regeneration;Nervous System Disorder;novel;novel strategies;Obesity;Organogenesis;paracrine;Patient Care;Physiological;Play;posters;preclinical development;Process;programs;Proliferating;protein complex;receptor;Receptor Protein-Tyrosine Kinases;repaired;Research;Research Personnel;research study;Role;Science;Scientist;senescence;Signal Transduction;skeletal;Skeleton;stem cells;success;symposium;Syndrome;System;targeted treatment;Texas;Therapeutic;therapeutic target;tissue repair;Tissues;tool;Travel;Underrepresented Populations;Variant;Woman;Work

PROJECT_TITLE: 2024 Fibroblast Growth Factors in Development and Disease Gordon Research Conference & Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (05)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pediatric

ORG_CITY: PROVIDENCE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BROWN UNIVERSITY

PI_NAMEs: MUNDY, MILES ALEXANDER (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Activated Natural Killer Cell;Acute;Acute respiratory infection;Animals;B-Lymphocytes;career;Cell Compartmentation;Cell Therapy;cell type;Cells;Cercopithecine Herpesvirus 1;congenital infection;Credentialing;Cytokine Receptors;Cytomegalovirus;Cytomegalovirus Infections;Data;Diagnostic;Environment;Exhibits;experimental study;Flow Cytometry;Frequencies;genetic manipulation;Histologic;Human;human model;imaging system;Immune;immune activation;Immune response;Immunocompromised Host;immunoreactivity;immunosuppressed;Impairment;In Vitro;in vivo;Individual;Infection;insight;International;intraperitoneal;Kinetics;Liver;Lower respiratory tract structure;Luciferases;Lung;Lung infections;Lymphocyte;Lymphoid Cell;Mentors;Methods;Modeling;mouse model;Murid herpesvirus 1;Mus;Natural Killer Cells;neonate;NK Cell Activation;Olfactory Epithelium;pathogen exposure;Pathogenesis;Pattern;Perinatal;Peripheral;Physiological;Physiology;Play;Population;postnatal;Predisposition;Prevalence;prevent;Pulmonary Inflammation;receptor;Research;Research Personnel;respiratory;response;Role;Route;Salivary Glands;seropositive;Seroprevalences;Site;Spleen;Structure of parenchyma of lung;symposium;Systemic infection;T-Lymphocyte;Time;Tissues;tool;Training;transmission process;Upper respiratory tract;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: The Role of Pulmonary Natural Killer Cells in Cytomegalovirus Induced Pneumonitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The Paramyxoviridae family includes several pathogenic viruses that pose major threats to human health, including human parainfluenza virus 3 (HPIV3) which causes illness or death in millions of infants and young children. The goal of the proposed research and graduate training vehicle is to elucidate host proteases required for HPIV3 infectivity, the impact of protease dependence on viral tropism, and how delaying proteolytic activation may enable virions to evade host defenses. The findings will broaden our understanding of viral fusion machinery and offer an ideal training opportunity.

PI_NAMEs: STEARNS, KYLE  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Affect;airway epithelium;Binding;Binding Proteins;Biochemical;Biological;Bronchiolitis;Cell membrane;Cell surface;cell type;Cells;Cessation of life;Child;Chimeric Proteins;Clinical;Complex;conformational conversion;Croup;Data;Dependence;Disulfides;Event;experimental study;extracellular;Family;fitness;gain of function;Glean;Glycoproteins;Goals;Golgi Apparatus;Health;Hemagglutinin;Host Defense;Human;Imaging Techniques;Infant;Infection;Integration Host Factors;Laboratories;Laboratory Finding;Learning;Life Cycle Stages;Link;Location;loss of function;Lung;Mediating;Membrane;Membrane Glycoproteins;Modeling;Molecular Conformation;Morphologic artifacts;Mucins;Neuraminidase;novel;Organoids;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;pathogenic virus;Peptide Hydrolases;Pneumonia;premature;preservation;pressure;prevent;Proliferating;Protein Precursors;Proteolysis;receptor;receptor binding;Research;Respiratory Disease;Respiratory System;RNA Viruses;Role;selective expression;sialic acid receptor;Sialic Acids;Site;Surface;Testing;Time;Tissues;Training;training opportunity;transmission process;Tropism;Viral;viral fitness;Viral Genome;Virion;virucide;Virus;Virus Diseases;Virus Inactivation

PROJECT_TITLE: Host Factors Required by Human Parainfluenza Virus 3: Determinants of entry and viral spread


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences;Nutrition

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Inflammation-induced anorexia is a common complication of inflammatory bowel disease, resulting in malnutrition, increased morbidity, and decreased quality of life. The goal of this proposal is to determine how peripheral inflammatory signals communicate with central food intake circuitry to ultimately drive anorexia. Not only will this contribute to the limited mechanistic understanding of inflammation-induced anorexia, but also may facilitate the development of treatment options that address the underlying immuno-metabolic causes.

PI_NAMEs: PROVINCE, HALEY  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Address;Anorexia;anorexic;Aversive Stimulus;Biometry;Body Weight decreased;Brain;Cachexia;Calcitonin Gene-Related Peptide;Calcium;career;Cells;Central Nervous System;Chronic;Clinical;Communication;Complex;Complication;computer program;Crohn's disease;cytokine;Data;Desire for food;dextran sulfate sodium induced colitis;Disease;Eating;Energy Metabolism;Enteral Nutrition;Equilibrium;experimental study;Feces;feeding;Fiber;gastrointestinal;Genetic;Goals;gut inflammation;gut-brain axis;Health;Homeostasis;Hormones;Hunger;Image;Immunologics;Immunology;in vivo;in vivo calcium imaging;indexing;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Interleukin-1 beta;Knowledge;Laboratories;Lateral;Leadership;lens;Lipopolysaccharides;Malignant Neoplasms;Malnutrition;Mediating;Microsurgery;Modeling;Morbidity - disease rate;mouse model;neural;neural circuit;Neurologist;neuronal circuitry;Neurons;Neurosciences;Nutritional;Nutritional Support;parabrachial nucleus;Parenteral Nutrition;Patients;Peripheral;Photometry;Physiological;Population;Prognosis;Quality of life;Research;response;Role;Satiation;Scientist;Signal Transduction;skill acquisition;Stimulus;targeted treatment;Techniques;Testing;therapy development;TNF gene;Training;tumor progression;Ulcerative Colitis;Viral

PROJECT_TITLE: Determining CGRP neuron contribution to inflammation-induced anorexia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative: Following viral respiratory infection, the cells required to maintain lung function are lost and must be restored. Epithelial repair via local stem and progenitor populations is well defined; however, immune-mediated mechanisms remain mysterious. This study will define novel mechanisms by which immune cells contribute to tissue repair.

PI_NAMEs: BAEZ VAZQUEZ, ALAN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Acute;Allergens;alveolar epithelium;Alveolar Macrophages;Anatomy;Automobile Driving;Bacteria;Biology;Cell Line;cell type;Cells;Communication;Development;Distal;Environment;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;experience;Exposure to;Fibroblasts;functional restoration;Gases;Genetic;Goals;Grant;grasp;Growth Factor;Guanine Nucleotide Exchange Factors;Homeostasis;Immune;Immune system;improved;in vivo;Individual;Infection;Inflammation;Influenza A virus;injured;Injury;Institution;Location;Lung;lung injury;lung repair;Macrophage;Maps;Mediating;medical schools;Mentors;Modeling;Molecular;Molecular Target;Mus;Natural regeneration;novel;Organism;Organoids;pathogen;Patient-Focused Outcomes;pharmacologic;Process;programs;pulmonary function;receptor;reconstitution;Recovery;repaired;Research;Resources;Respiratory Tract Infections;response;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Slide;social;spatiotemporal;Stable Populations;stem;stem cell function;stem cell population;Stimulus;Testing;Time;tissue regeneration;tissue repair;Tissues;Toxin;transcriptomics;Viral;viral pandemic;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Macrophage-Mediated Lung Repair Programs Following Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Vesicles produced by Bacteroides spp. are proposed to modulate host immunity and mediate interbacterial and cross kingdom interactions, but the mechanisms controlling vesiculation are unknown. The proposed research will characterize a family of structurally novel proteins that induce vesicle production via a tightly controlled regulon. This work will provide critical insight into how Bacteroides spp. produce and utilize vesicles to shape their surroundings.

PI_NAMEs: PARDUE, EVAN J (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TITLE: Novel Family of Dual Membrane-Spanning Anti-sigma factors Regulate OMV Biogenesis in Bacteroides thetaiotaomicron

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Substance Misuse Prevention

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative. Harm reduction has emerged as a critical approach for addressing the opioid epidemic, but harm reduction approaches are not widely made available nor equitably made available to persons with opioid use disorder. This proposal aims to understand patterns of harm reduction services recommended to persons with opioid use disorder while they are in the hospital, and the uptake of such services, by analyzing clinical notes within the electronic health record using a data science approach called natural language processing.

PI_NAMEs: ISRAEL, KHADIJA  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Adverse event;Black Populations;Black race;Caring;Categories;Clinical;Collection;Consult;cost effective;Counseling;Data;Data Science;Death Rate;Disease;Disparity;Drug usage;Electronic Health Record;Enrollment;Equity;ethnic difference;Ethnic Origin;Evaluation;fentanyl contamination;fentanyl test;Funding;General Population;Harm Reduction;Health;health difference;Helping to End Addiction Long-term;hospital care;hospitalization rates;Hospitals;improved;inequitable distribution;Inequity;Injections;Intervention;Language;Latino;Latino Population;Link;Logistic Regressions;Logit Models;Medical;medication for opioid use disorder;Medicine;Methods;Modeling;mortality;naloxone dispensing;National Institute of Drug Abuse;Natural Language Processing;New York City;Opioid;opioid epidemic;opioid use;opioid use disorder;opioid user;overdose death;overdose prevention;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Prevention;primary outcome;programs;Provider;psychosocial;Public Health;public health priorities;Public Hospitals;Quality of life;Race;racial difference;Recommendation;Research;Research Methodology;Risk Reduction;Route;secondary outcome;Services;Site;Social Conditions;social stigma;Statistical Methods;Strategic Planning;substance use;substance use treatment;success;System;Techniques;test strip;Text;theories;Training;uptake

PROJECT_TITLE: Understanding inequities in harm reduction services provided to persons with opioid use disorder in hospital settings: Harnessing the power of natural language processing.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project narrative We will develop the next-generation, ultrasensitive stimulated Raman scattering (SRS) microscopy by integrating innovations from imaging instrumentation, probe chemistry and data science. This research will bring SRS microscopy to the ultimate sensitivity (comparable to that of fluorescence microscopy), and fully open the application in live cell biology.

PI_NAMEs: BUCCELLA, DANIELA ;CHENG, JI-XIN  (contact);MIN, WEI

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Adopted;Biochemical Pathway;Biological;Biophotonics;cancer cell;Carbon;Cations;Cells;Cellular biology;chemical bond;Chemicals;Chemistry;clinical translation;Color;commercialization;Coupled;Data Science;denoising;design;Detection;detection limit;Deuterium;Development;Device or Instrument Development;divalent metal;Environment;Exhibits;Fluorescence;Fluorescence Microscopy;Fluorescence Spectroscopy;Foundations;Goals;Grant;Hepatocyte;Image;imaging modality;imaging probe;innovation;instrumentation;invention;Ions;Isotopes;Label;Lasers;Libraries;lipid metabolism;live cell imaging;liver imaging;machine learning algorithm;Maps;Metals;Methods;Microscopy;millisecond;Modality;molecular imaging;Molecular Target;Monitor;multiplexed imaging;nanometer;nanomolar;Nature;next generation;Optics;Organism;Pharmaceutical Preparations;Photons;Physiologic pulse;Raman Spectrum Analysis;Reaction;Reporter;Reporting;Research;Research Personnel;Resolution;Sampling;Science;sensor;Signal Transduction;small molecule;Source;spectroscopic imaging;Spectrum Analysis;Speed;Structure;success;System;Techniques;Technology;temporal measurement;Time;Tissues

PROJECT_TITLE: Super-sensitive vibrational imaging by synergic development of instruments and probes


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Mathematical models that help predict cases and hospitalizations of COVID-19 are essential for policy makers and the public to plan public health interventions and prepare for outbreaks and typically rely on data about cases. As data on cases has become less reliable and sparser, wastewater surveillance has emerged as a new source of data for tracking infections; however, it is not clear yet how wastewater surveillance can be used to improve modeling of transmission. This project will take advantage of a unique collaboration with the New York State Wastewater Surveillance Network to find out how wastewater surveillance data may be used to improve SARS-CoV-2 forecasting and protect the public health.

PI_NAMEs: GORIN, EMMA MAY (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Affect;Algorithms;antigen test;Bayesian Analysis;Case Study;Clinical;Collaborations;Communicable Diseases;cost effective;County;Coupled;COVID-19;COVID-19 incidence;Data;Data Set;Data Sources;data streams;Development;disease model;Disease Outbreaks;Feces;Frequencies;Future;future outbreak;Goals;Home;Hospitalization;hospitalization rates;Human;improved;Infection;infectious disease model;Investments;Location;mathematical model;Measurement;Modeling;Monitor;New York;Noise;pathogen;Plants;Policy Maker;Population;population movement;Public Health;public health intervention;Reporting;Research;research clinical testing;Research Personnel;Resources;Risk Assessment;SARS-CoV-2 infection;SARS-CoV-2 transmission;Shamanism;Societies;Source;Statistical Models;Structure;Study models;surveillance data;Surveillance Modeling;surveillance network;System;Testing;transmission process;Variant;wastewater surveillance

PROJECT_TITLE: Investigating the potential of wastewater surveillance data to improve SARS-CoV-2 dynamical modeling and forecasting


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Detecting interactions between cellular perturbations requires an appropriate model for non-interaction (i.e., a null interaction model). A key challenge is the design of null interaction models for biological assays with high- dimensional phenotypes, in which individual features exhibit unknown, non-linear behavior. I propose to establish an analytical approach to construct null interaction models for high-dimensional phenotypes and perform drug target identification using high-dimensional, chemical-genetic interactions.

PI_NAMEs: RAO, LEE  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acceleration;Behavior;Benchmarking;Biological;Biological Assay;Biological Markers;Biological Models;Cell Separation;Cell Shape;Cell Survival;Cells;Cellular Morphology;chemical genetics;Clinical Trials;combinatorial;Complex;Data;Data Set;design;Detection;Development;drug candidate;Drug Combinations;drug discovery;Drug Interactions;Drug Targeting;Drug usage;Exhibits;experimental study;fitness;Gene Expression;Genes;Genetic;Genetic Screening;Goals;high dimensionality;High-dimensional Modeling;Image;improved;in situ sequencing;Individual;inhibitor;insight;Learning;lens;MAP2K1 gene;Maps;Measurement;Measures;member;Methods;Microscopy;Modeling;Molecular;neural network;novel;Pathway interactions;Performance;Pharmaceutical Preparations;Phenotype;Publishing;Reporter;Resolution;Sampling;Signal Transduction;simulation;synergism;synthetic data;Texture;Therapeutic Index;Toxic effect;Training;vector

PROJECT_TITLE: Accurate interaction detection in combinatorial screens with complex phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung

PHR: Project Narrative COPA syndrome, an autosomal dominant monogenic disease causing autoinflammation and interstitial lung disease (ILD), results from defects in Golgi to Endoplasmic Reticulum retrieval of stimulator of interferon genes (STING) by coatomer subunit α (COPA). This proposal characterizing which STING functions are preserved or defective in a common STING allele that is associated with non-penetrance of pathogenic COPA mutations. STING hyperactivation has been broadly implicated in ILD, thus these studies hold potential to unlock novel therapeutic approaches for this group of morbid diseases.

PI_NAMEs: SIMCHONI, NOA  (contact)

PROJECT_TERMS: Affect;Agonist;Alleles;Alveolar;Autoantibodies;Autoimmune Diseases;autoinflammation;Automobile Driving;Autophagocytosis;autosome;Cell Death;Cell Line;Cells;Chromosome Mapping;Chronic;Cicatrix;Clinical;Code;Competence;Confocal Microscopy;Connective Tissue Diseases;Cyst;Data;Defect;Disease;Disease Pathway;Disease Progression;disorder control;DNA;Endoplasmic Reticulum;experimental study;fibrotic lung;Flow Cytometry;Gene Activation;Gene Expression;gene function;Genes;Genetic;genetic variant;Golgi Apparatus;Hemorrhage;Heterozygote;Human;Immune;immune activation;Immunosuppression;Impairment;Inflammation;Inflammatory;Inflammatory Arthritis;Innate Immune Response;Interferon Type I;Interferons;Interstitial Lung Diseases;Kidney Diseases;knockout gene;Laboratory Study;Lentivirus Vector;Lung;Lung Diseases;Lung Transplantation;Lysosomes;Mendelian disorder;Messenger RNA;Modeling;Morbidity - disease rate;mortality;mRNA Expression;mutant;Mutate;Mutation;mutation carrier;NF-kappa B;nonsynonymous mutation;novel therapeutic intervention;Output;Pathogenesis;Pathogenicity;Patients;Penetrance;Peripheral Blood Mononuclear Cell;Phosphorylation;Physiological;preservation;prevent;Production;protein expression;protein transport;Proteins;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Rare Diseases;Reporter;response;Rest;Retrieval;Role;segregation;senescence;Signal Transduction;Sorting;stable cell line;Stimulator of Interferon Genes;Syndrome;Testing;Time;Variant

PROJECT_TITLE: Exploring Mechanisms Through Which STING Alleles  Impact Clinical Penetrance of COPA Syndrome


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) occurring in adolescents and young adults aged less than 40 years is associated with worse health outcomes. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a relatively new T2D treatment, but how well they work in adolescents and young adults outside of clinical trials is unknown. The purpose of this study is to use a large-scale database to test how GLP-1 RAs are prescribed and how well they work in adolescents and young adults in the real world.

PI_NAMEs: CHU, PATRICIA YEA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 17 year old;Acceleration;access disparities;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;age stratification;aged;Agonist;B-Lymphocytes;Biometry;Body Weight decreased;Cardiovascular Diseases;career development;Cell Physiology;Characteristics;Clinical;clinical epidemiology;Clinical Research;Clinical Trials;cohort;compare effectiveness;comparison control;Complex;Complications of Diabetes Mellitus;Data;Database Management Systems;Databases;Degree program;design;diabetes control;Diabetes Mellitus;diabetes mellitus therapy;Diagnosis;Dipeptidyl Peptidases;Doctor of Pharmacy;Doctor of Philosophy;early onset;Effectiveness;Electronic Health Record;epidemiology study;ethnic disparity;Fellowship;Future;GLP-I receptor;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Grant;Healthcare Systems;inhibitor;insight;insulin secretion;Insurance;Interruption;Intervention;large-scale database;Learning Skill;liraglutide;Logistic Regressions;longitudinal analysis;Master of Science;Mentors;Mentorship;Metabolic Diseases;Methods;Microvascular Dysfunction;Minority;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;patient oriented research;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Physicians;poor health outcome;Population;preservation;Prevalence;prevent;Privatization;public health insurance;racial disparity;Research;Research Design;Research Methodology;Research Training;Risk;Scientist;Series;socioeconomic disadvantage;Socioeconomic Factors;Sodium;Sulfonylurea Compounds;symporter;System;Testing;Time;Training;training opportunity;Training Programs;treatment optimization;trial comparing;United States;United States Food and Drug Administration;Vulnerable Populations;Work;young adult;Youth

PROJECT_TITLE: Real-world Effectiveness and Utilization of Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Type 2 Diabetes in Adolescents and Young Adults

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Clear cell renal cell carcinoma (ccRCC) is frequently driven by increased activity of the hypoxia- inducible transcription factor HIF2. We demonstrated that the circadian clock components BMAL1, CRY1, and CRY2 regulate the activity of HIF2. This project investigates contributions of circadian clock components to HIF2 activity and cell and tumor growth in ccRCC.

PI_NAMEs: LAMIA, KATJA A (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: angiogenesis;antagonist;ARNT gene;ARNTL gene;Atlases;Automobile Driving;Behavior;BHLH Protein;cancer type;cell growth;Cell Line;Cells;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clear cell renal cell carcinoma;Clinical;cryptochrome 1;cryptochrome 2;Data;Development;DNA Binding;DNA Sequence Alteration;Drug Interactions;Elements;Exhibits;experience;Feedback;Gene Activation;Gene Expression;gene repression;Genes;genetic signature;Genetic Transcription;Growth;Helix-Turn-Helix Motifs;Heterodimerization;Homologous Gene;Human;Hypoxia;hypoxia inducible factor 1;insight;Kidney;male;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Metabolism;Molecular;Mutation;MYC Family Protein;Nuclear Hormone Receptors;patient derived xenograft model;Patients;Persons;Physiology;prevent;Proliferating;Proteins;Proteolysis;recruit;Regulation;Repression;Research;Resistance;response;Risk;Role;Sampling;shift work;small hairpin RNA;The Cancer Genome Atlas;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translations;Travel;tumor growth;tumor xenograft;ubiquitin-protein ligase;women patients;Xenograft procedure;ZNF151 gene

PROJECT_TITLE: CIRCADIAN REGULATION OF HIF2alpha IN ccRCC

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE The Dobbs v. Jackson Women’s Health Organization Supreme Court decision, which overturned a half century of legal precedent that protected the right to induced abortion, is a landmark policy change with implications for fertility, population health, and related disparities in the US. The proposed research will use a comparative interrupted time series design to estimate the impact of the Dobbs decision on fertility and maternal and infant health outcomes over time and by subgroups in states that recently banned or restricted abortion services. This work will address major gaps in the literature regarding the causal impact of abortion restrictions on population health, in particular post-Dobbs abortion restrictions, for which we currently have limited knowledge, and produce results that can inform time-sensitive reproductive health policy decision making in states in the coming years.

PI_NAMEs: BELL, SUZANNE O'DEA;GEMMILL, ALISON  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Abortion Rates;Accounting;adverse birth outcomes;Advocate;Age;aged;Birth;Birth Certificates;Birth Rate;Black Populations;Black race;Caring;Censuses;clinical practice;comparative;court;COVID-19;Data;Databases;Decision Making;design;Disparity;Disparity population;Educational Status;Ethnic Origin;experience;Exposure to;Fertility;Fertility Rates;health disparity;health organization;Health Policy;Hispanic;Hispanic Populations;Hospitalization;Hospitals;Induced Abortion;Infant;Infant Health;infant outcome;Inpatients;Interruption;Justice;Knowledge;Legal;Literature;Live Birth;Location;Low Birth Weight Infant;Marital Status;Maternal complication;Maternal Health;Measures;Midwestern United States;Modeling;Outcome;Pattern;payment;Persons;Policies;Population;population health;Poverty;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;Prenatal care;Race;reproductive;Reproductive Health;Research;Research Personnel;Rights;Risk;Series;Services;severe maternal morbidity;Small for Gestational Age Infant;sociodemographics;Source;stillbirth;Stress;Subgroup;Supreme Court Decisions;Texas;Time;Time trend;trend;Unmarried;Voice;Woman;Women's Health;Work

PROJECT_TITLE: The fertility, maternal health, and infant health consequences of reproductive policy change

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Multiple microRNAs (miRNAs) have been identified as key modulators of neutrophils. In our study, we will uncover which specific genes in miR-31 are involved in neutrophil motility. The innovative knowledge obtained from this study will provide new information on mechanisms that regulate neutrophil motility and lead to possible treatments for inflammation related diseases.

PI_NAMEs: PIKES, TYLER  (contact)

PROJECT_TERMS: Actins;Affect;angiogenesis;Anti-Inflammatory Agents;Arthritis;Asthma;Autoimmune Diseases;Biological;Biological Assay;Biological Process;Biotin;Calcium;Cell Adhesion;cell motility;Cell Nucleus;Cells;Chemotactic Factors;Chemotaxis;chronic inflammatory disease;Circulation;Clutch Size;Complex;CRISPR/Cas technology;cytokine;Cytoplasmic Granules;Data;Defect;Disease;Ephrins;fighting;gene discovery;gene function;gene repression;Gene Silencing;Gene Targeting;gene therapy;gene-targeted therapy;Genes;Genetic Screening;Genetic Transcription;Heart;Homeostasis;Human;Image;Immune response;Immune system;in vivo;Infarction;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;Innate Immune System;innovation;Knock-out;Knowledge;Label;Larva;Leukocytes;Ligase;Lipids;Luciferases;Malignant Neoplasms;Mediating;Messenger RNA;Methods;MicroRNAs;migration;Molecular;Morphogenesis;Motility;mouse model;Mutation;Natural Immunity;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel therapeutics;overexpression;pathogen;Pathology;Phagocytosis;Phenols;Phenotype;PIK3CG gene;Process;Proteins;Reactive Oxygen Species;recruit;Regulation;repaired;Reporter;Reporting;Respiratory Burst;response;Role;Signal Pathway;Small RNA;Techniques;therapeutic development;Time;Tissues;Transcript;wound;wound healing;Zebrafish

PROJECT_TITLE: MicroRNA-31 regulates neutrophil migration and activation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE (3 sentences) Although men involved in the criminal justice system have been noted as a “high-priority target population” among sexual and reproductive health experts for at least two decades, we know almost nothing about formerly incarcerated young men’s sexual and reproductive health attitudes and behaviors, as well as their experiences with, and barriers and facilitators to, accessing sexual and reproductive health education and care. Drawing from population-based survey data and data collected from in-depth interviews with recently incarcerated young men (ages 15-29) and national and regional justice, medical, and public health experts, this study will inform the development of interventions to support the sexual and reproductive health goals, education, and care of formerly incarcerated young men, and will provide critical preliminary data to develop a national agenda for further research centering this neglected and understudied group.

PI_NAMEs: GEMMILL, ALISON  (contact);JACKSON, DYLAN B.

PROJECT_TERMS: 17 year old;Address;Adolescent;adolescent health;Adolescent Medicine;Age;aged;Area;Attitude;Attitude to Health;Behavior;Biological;Birth;Caring;Child;Communities;Complex;Consensus;Contraceptive methods;Country;Criminal Justice;Criminology;Data;Demography;Development;developmental psychology;Disadvantaged;Economically Deprived Population;Education;eligible participant;experience;Family;Family health status;Family Planning;Fathers;Female;Goals;Growth;Harm Reduction;Health education;health goals;Healthcare;high risk;Imprisonment;Individual;Inequality;informant;Intervention;Interview;Justice;Lived experience;male;Maryland;Medical;men;Methodology;Midwestern United States;Minnesota;Minority;neglect;Nonprofit Organizations;Outcome;Participant;Population;population based;Pregnancy;Public Health;Recording of previous events;recruit;Regression Analysis;Reporting;reproductive;Reproductive Health;Reproductive Health Services;Research;Risk;Sampling;sexual and reproductive health;sexual risk reduction;social determinants;socioeconomic disadvantage;statistics;Structure;Surveys;System;Target Populations;Texas;therapy development;unintended pregnancy;Woman;young man;Youth

PROJECT_TITLE: Understanding the Complex Reproductive Health Needs of Formerly Incarcerated Young Men


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Lymphatic Research;Muscular Dystrophy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative  The glymphatic system is a recently characterized pathway of cerebrospinal and interstitial fluid circulation, facilitating solute transport and thought to be important for the removal of toxic amyloid-beta and tau aggregations, two neuropathological hallmarks of Alzheimer’s disease (AD). The proposed work will investigate how changes in mRNA expression of key glymphatic genes and common genetic variation in genes of this pathway contribute to glymphatic dysfunction in AD, potentially rendering certain individuals more susceptible to AD neuropathology and subsequent cognitive decline. This work will characterize key genes in the glymphatic pathway that could be targeted for future mechanistic studies, providing critical information for the development of disease-modifying therapeutics to prevent the accumulation of toxic proteins.

PI_NAMEs: PHILLIPS, JARED  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Abeta clearance;Acceleration;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloidosis;aquaporin 4;Architecture;Astrocytes;Autopsy;Biological Markers;Brain;Brain region;career;caudate nucleus;Cell Death;Cerebrospinal Fluid;Cessation of life;cingulate cortex;Circulation;Cognition;Cognitive;cohort;Cohort Studies;Complex;Data;Databases;Dementia;Development;Disease;Drainage procedure;dystrobrevin;Dystroglycan;Dystrophin;Elderly;Ensure;Etiology;Excision;extracellular;fluid flow;Future;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;genomic tools;Genomics;Genotype;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Histologic;Human;Impaired cognition;improved;Individual;innovation;Intercellular Fluid;Interdisciplinary Study;Knock-out;Knowledge;Measurement;Measures;Medicine;Memory;Mentorship;Modeling;Molecular;mRNA Expression;multidisciplinary;multimodality;multiple omics;Nerve Degeneration;Neurobiology;Neurofibrillary Tangles;Neuronal Dysfunction;neuropathology;Neuropsychology;Neurosciences;novel;novel therapeutics;Outcome;Pathogenesis;Pathology;Pathway interactions;Play;Population;Positioning Attribute;Predisposition;Prefrontal Cortex;prevent;Prevention;Proteins;Regression Analysis;Regulation;religious order study;Research;resilience;Resources;RNA Sequences;Rodent Model;Role;Route;Scientist;Senile Plaques;skills;solute;syntrophin alpha1;tau aggregation;tau Proteins;theories;Therapeutic;therapeutic development;tool;Training;transcriptome sequencing;transcriptomics;Universities;Up-Regulation;Waste Products;water channel;Work;β-amyloid burden

PROJECT_TITLE: AQP4 Associations with Alzheimer's Disease: A Multi-omics Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Children’s early language learning abilities are critical to their long-term outcomes with regard to acquiring language, forming social connections, and succeeding in school. This project’s goal is to investigate how very young children manage the massive variability inherent in human speech, an unsolved problem in theories of language learning. This research will have substantial implications for our understanding of typical language development and for translational work developing early language assessments and interventions.

PI_NAMEs: BEECH, CAROLINE WENDELL (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TITLE: Infant word learning and word recognition under realistic phonetic conditions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE  The incidence of liver cancer continues to rise, and the poor survival rates of advanced disease highlight a dire need for new understanding and therapies. This fellowship application explores how the enzyme histone deacetylase eleven (HDAC11) drives liver cancer and tests HDAC11 inhibition as a possible treatment avenue. Completion of this research proposal and training plan fills major knowledge gaps, and it offers a platform to prepare a promising candidate for a career as a cancer investigator.

PI_NAMEs: CLEMENTS, JENNA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: advanced disease;Affect;Alternative Splicing;Analysis of Variance;Animal Experimentation;anti-cancer research;BAY 54-9085;Binding Sites;Biochemistry;Biological Assay;Biometry;c-myc Genes;cancer cell;Cancer Cell Growth;cancer stem cell;cancer therapy;career;CD44 gene;Cell Line;Cell Nucleus;Cell Survival;Cells;Characteristics;Chemistry;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Computational Technique;Data;Deacetylation;Disease;Disease Progression;Drug resistance;drug sensitivity;Ensure;Enzymes;Epigenetic Process;Excision;experimental study;Family member;Fatty Acids;fatty acylation;Fellowship;Flow Cytometry;Fluorescence Microscopy;Genes;Goals;Growth;HDAC11 gene;Hepatocarcinogenesis;hepatocellular carcinoma cell line;Histone Deacetylase;Histones;Hydrolase;Image;in vivo;Incidence;inhibitor;Injections;innovation;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Liver;liver biopsy;Liver neoplasms;Location;Luciferases;luminescence;Lysine;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Messenger RNA;Microscopy;Modeling;Molecular;Monitor;mortality;mRNA Expression;Mus;new therapeutic target;novel therapeutics;Nuclear;Oncogenes;Oncogenic;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;Primary carcinoma of the liver cells;prognostic;Protein Isoforms;Protein Splicing;Proteins;Proteomics;Regulation;Reporting;Reproducibility;Research;Research Personnel;Research Proposals;Research Training;RNA;RNA Splicing;Role;self-renewal;Signal Pathway;skills;small molecule inhibitor;stable cell line;standard care;Statistical Data Interpretation;stem cell genes;stem cell population;stemness;Survival Analysis;Survival Rate;Tail;Techniques;Testing;Tissues;TP53 gene;Training;training opportunity;transcriptome sequencing;Transfection;Transposase;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Variant;Veins;Western Blotting

PROJECT_TITLE: Targeting HDAC11 to combat hepatocellular carcinoma and regulate alternative RNA splicing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Diabetes

ORG_DEPT: BIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE There is currently an unmet demand for therapies that preserve and/or rescue pancreatic β-cell function in the progression of type 2 diabetes (T2D). Our mouse model uses continuous stress-independent activation of ATF6α in β-cells to drive diabetes, and may be useful for uncovering novel molecular mechanisms regulated by ATF6α that explain one aspect of the damaging effect of chronic stress that diminishes β-cell function in T2D. We believe our proposed experiments, which use transmission electron microscopy, RNA- sequencing, and the gold-standard islet perifusion assay to analyze insulin secretion, will contribute valuable knowledge for developing therapies to preserve and/or rescue β-cell function in T2D.

PI_NAMEs: RAPPA, ANDREW  (contact)

PROJECT_TERMS: Actins;Acute;acute stress;ATF6 gene;ATP sensitive potassium channel complex;Beta Cell;Biochemical;biological adaptation to stress;Biological Assay;Blood Glucose;blood glucose regulation;Calcium;career;Cell Physiology;Cell Survival;cell type;Cellular biology;Chronic stress;constitutive expression;Cyclic AMP;Data;Defect;DHFR gene;Diabetes Mellitus;Dihydrofolate Reductase;disulfide bond;Educational process of instructing;Endoplasmic Reticulum;endoplasmic reticulum stress;Enterobacteria phage P1 Cre recombinase;Escherichia coli;experimental study;Exposure to;Functional disorder;Gene Expression;Genetic Transcription;Glucose;Glucose Intolerance;glucose metabolism;glucose uptake;Human;Impairment;in vivo;in vivo evaluation;Insulin;insulin granule;insulin secretion;intraperitoneal;islet;Knock-in Mouse;Knowledge;Link;Literature;Messenger RNA;metabolic abnormality assessment;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;N-terminal;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathway interactions;pharmacologic;preservation;Process;Production;Proinsulin;protective effect;Protein Biosynthesis;Proteins;response;Role;Scientist;Signal Transduction;Stress;Structure of beta Cell of islet;Techniques;Technology;Testing;therapy development;transcriptome sequencing;Transmission Electron Microscopy;Trimethoprim;Variant

PROJECT_TITLE: Forced Activation of ATF6 Drives Pancreatic Beta Cell Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Signaling between cells is essential for the proper development and function of neural circuits and occurs often over long distances. This project will test the hypothesis that extracellular vesicles are a novel long-distance mechanism of intercellular neurotrophin signaling which promotes recipient neuron survival. Ultimately, this work will increase our understanding of the mechanisms required for the proper target-directed circuit refinement in the developing nervous system.

PI_NAMEs: SEWELL, JONATHON  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acetylcholine;Address;Apoptosis;Axon;Binding;Brain-Derived Neurotrophic Factor;Cell Death;Cell membrane;Cell Separation;Cell Survival;cell type;Cells;Cessation of life;Characteristics;Communication;CREB1 gene;Cytometry;Data;Dendrites;Development;Distal;Endocrine;Endosomes;Ensure;Event;Exhibits;experimental study;Exposure to;extracellular vesicles;Eye;Family member;Ganglia;Image;improved;In Vitro;in vivo;Knowledge;Lysosomes;Measures;Mediating;Modeling;Motor;Motor Neurons;Nerve Growth Factors;Nervous System;nervous system development;neural circuit;neuronal cell body;neuronal survival;Neurons;Neurophysiology - biologic function;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;Norepinephrine;novel;Organ;Pathway interactions;Peripheral Nervous System;Phosphorylation;Process;protein biomarkers;Publications;receptor;Receptor Protein-Tyrosine Kinases;Resolution;response;retrograde transport;Role;Salivary Glands;Signal Pathway;Signal Transduction;Specificity;Spinal Cord;Spinal Cord Column;Synapses;synaptogenesis;System;Techniques;Testing;trafficking;Up-Regulation;uptake;Visceral;Visualization;Work

PROJECT_TITLE: The role of extracellular vesicles as a novel trophic signaling platform in nervous system development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Applicant: Andrea Bucknam Project Narrative Medicinal chemistry programs continue to be fueled by rapid access to classes of natural products with demonstrated pharmaceutically-relevant biological activity, and molecularly flexible total synthesis programs expand access to enantiomerically enriched natural products and natural product-like compounds to broaden the investigation of their potential as therapeutics. There are greater than 100 FDA-approved drugs which are tetracyclic triterpenoid natural products, and yet some classes of tetracyclic triterpenoids–including cardenolides–have yet to be investigated deeply as drug candidates despite their structural relatedness to in-use pharmaceutical agents. The research proposed herein is an asymmetric de novo synthesis of sarmentogenin, a cardenolide natural product utilizing a novel oxidative dearomatization/Wagner-Meerwein rearrangement to establish a key quaternary center and oxidation pattern characteristic of the cardenolide carbon framework in a stereospecific manner.

PI_NAMEs: BUCKNAM, ANDREA RACHEL (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TITLE: Asymmetric de Novo Synthesis of a Cardenolide: The Total Synthesis of Sarmentogenin

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: PROJECT NARRATIVE Trifluoromethyl groups are common in small-molecule therapeutics, due to the dramatic improvement in pharmacokinetic properties caused by the presence of C–F bonds. A significant limitation of established methods for the incorporation of trifluoromethyl groups into organic molecules is the high cost of many commonly employed trifluoromethylation reagents, which hinders the discovery and synthesis of new trifluoromethylated pharmaceuticals. This proposal describes the trifluoromethylation of organic compounds using a silver(II) catalyst together with inexpensive, abundant trifluoroacetate as the trifluoromethylation reagent.

PI_NAMEs: RAGURAM, ELAINE REICHERT (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Photoelectrocatalytic Trifluoromethylation of Arenes via Trifluoroacetate Decarboxylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Experience-induced patterns of brain development in bilingual children have either not been taken into account or been explicitly excluded from foundational longitudinal neuroimaging studies characterizing developmental trajectories of brain language and reading networks. This creates critical barriers to understanding the development of reading networks in emergent typical and struggling bilingual readers. The overarching goals of this proposal are to disentangle how bilingualism and reading development shape brain structure during childhood and to reveal compensatory neural mechanisms associated with better outcomes in struggling bilingual readers.

PI_NAMEs: RONDEROS, JULIANA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Adult;Affect;Age;Anisotropy;Area;base;bilingualism;Brain;Brain region;brain shape;Characteristics;Child;Childhood;cognitive control;cognitive development;cognitive function;Communication;Complex;critical period;Data;design;Development;Disadvantaged;Distal;Dorsal;dorsal visual stream;Education;English Language;Exclusion;experience;functional adaptation;Funding;Goals;gray matter;Growth;Household;insight;Knowledge;Language;language comprehension;Language Development;language processing;Latinx;Learning;Left;Link;longitudinal dataset;Measures;Modeling;multimodal data;neural;Neural Pathways;neuroimaging;neuromechanism;Neuronal Plasticity;Outcome;Pathway interactions;Pattern;peer;Population Heterogeneity;Process;Reader;Reading;reading ability;Research;Sampling;School-Age Population;Schools;Shapes;Short-Term Memory;skills;Structure;theories;Time;Uncertainty;United States National Institutes of Health;ventral visual stream;Vocation;white matter;Work;Writing

PROJECT_TITLE: Longitudinal trajectories of white matter and reading development in bilingual children


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE In the US, 1 in 14 pregnant people smoke cigarettes during pregnancy; prenatal nicotine exposure leads to an increased risk of developing several neurobehavioral disorders (e.g., ADHD and autism spectrum disorders). Pressingly, the cellular and molecular mechanisms by which the nicotinic cholinergic system modulates circuit and synapse maturation, and how these are dysregulated by nicotine exposure during early brain development, remain poorly understood. Characterizing the role of the nicotinic cholinergic signaling in circuit and synapse maturation will expand our knowledge of brain development and elucidate therapeutic targets to mitigate the adverse outcomes of prenatal nicotine exposure.

PI_NAMEs: GOMEZ WULSCHNER, LUIS E (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Address;adverse outcome;alpha-bungarotoxin receptor;Attention deficit hyperactivity disorder;autism spectrum disorder;basal forebrain;Bathing;Behavioral;Brain;Calcium;Cerebral cortex;cholinergic;Cholinergic Receptors;Cigarette;cigarette smoke;Color;critical period;Data;Dendritic Spines;Denervation;Development;Down-Regulation;Electronic cigarette;Electrophysiology (science);Etiology;Excitatory Synapse;executive function;experimental study;fetal;Functional disorder;Genetic;Glutamates;hippocampal pyramidal neuron;Impairment;in vivo;Individual;innovation;Investigation;Ion Channel;Knowledge;Light;Link;Mediating;Membrane Potentials;Microscopy;Molecular;neonatal mice;neurobehavioral disorder;Neurodevelopmental Disorder;Neuromodulator;neuronal circuitry;Neurotoxins;Nicotine;nicotine exposure;nicotine treatment;Nicotinic Receptors;Output;Permeability;Persons;pharmacologic;Pharmacology;Physiological;Play;postsynaptic;Prefrontal Cortex;Pregnancy;pregnant;prenatal nicotine exposure;presynaptic;Public Health;Receptor Activation;Receptor Signaling;receptor-mediated signaling;Reporting;Rest;Risk;Role;Signal Transduction;Slice;Smoking;Structure;Synapses;System;Techniques;Testing;therapeutic target;transmission process;two-photon;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: Nicotinic modulation of excitatory synapse development in the prefrontal cortex


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Tourette Syndrome

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Tourette Syndrome (TS) is a highly prevalent neurological disorder in which the underlying neuropathology still remains poorly understood and under investigated. This grant proposal will utilize novel preclinical mouse models expressing orthologous human mutations in high-confidence TS genes to investigate the underlying circuit mechanisms of TS. These experiments will begin to reveal the uninvestigated neuronal substrates of habit formation and dopamine dysregulation hypothesized in TS, as well as aid in future research for improving therapeutics/interventions for TS.

PI_NAMEs: KOWALSKI, TESS FELICIA (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Animal Model;Applications Grants;aripiprazole;Axon;Behavior;Behavior Therapy;behavioral study;Biological Assay;Biosensor;Body part;Brain;Characteristics;Chemosensitization;Child;Chronic;comorbidity;compulsion;Corpus striatum structure;Coupled;Data;design;Dopamine;Dopamine Receptor;Dorsal;drug action;Drug usage;Esthesia;Etiology;Exhibits;experience;experimental study;Face;Female;Fiber;Genes;Gilles de la Tourette syndrome;Goals;Grant;Habits;High Prevalence;Human;human subject;improved;in vivo;in vivo imaging;Individual;insight;Interval training;Intervention;learned behavior;Learning;Link;male;Measures;Modeling;Motor;motor learning;mouse model;Movement;Mus;Mutate;Mutation;Nervous System Disorder;neural;Neurobiology;Neurodevelopmental Disorder;Neuromodulator;Neurons;neuropathology;novel;novel therapeutic intervention;Obsessive-Compulsive Disorder;Operant Conditioning;Outcome;Participant;Patients;Performance;Pharmaceutical Preparations;Phenotype;Photometry;pre-clinical;proband;Quality of life;Reporting;Research;response;Response to stimulus physiology;Rewards;sensor;Severities;sex;Sex Differences;Signal Transduction;Slice;sound;Stereotyping;stereotypy;Stimulus;Substance abuse problem;System;Testing;Therapeutic;Tic disorder;Training;treatment strategy

PROJECT_TITLE: Investigating habitual behavior and dopamine dysregulation in Tourette Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Cortical resections of brain tissue in children with drug-resistant epilepsy may damage parts of the broad network of cortical regions which interact with subcortical structures to control oculomotor function. This project aims to understand the extent to which key eye movements such as smooth pursuit and saccades are affected by such resections, how intact cortical regions involved in oculomotor control may adapt after resection of other areas, and whether neural and behavioral changes in oculomotor function have consequences for higher-order cognitive processes (e.g. such as when eye movements are critical for search of a complex display). These studies will be the first to systematically assess oculomotor function of smooth pursuit and saccades after pediatric epilepsy surgery and their postsurgical functional consequences, providing insight into the neuroplastic potential and limitations of the oculomotor system and its function; they will also expand understanding of both surgical risk and recovery in this population, and will open avenues for future investigations into interventions that will improve outcomes.

PI_NAMEs: CHRONEOS, MARIA ZDENKA (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;Affect;Age;Area;Attention;base;Behavior;Behavioral;blind;Brain;brain behavior;Brain region;brain tissue;career;Cerebral hemisphere;Child;Childhood;childhood epilepsy;Clinical;Cognitive;cognitive function;cognitive process;comparison control;Compensation;Complex;daily functioning;Data;Databases;Decision Making;design;Development;developmental plasticity;Drug resistance;Environment;Epilepsy;Evaluation;Excision;Exhibits;Experimental Designs;Eye;Eye Movements;flexibility;fovea centralis;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Hemianopsia;Hemispherectomy;Human;imaging modality;improved outcome;insight;Interruption;Intervention;Intractable Epilepsy;Investigation;Lead;Lesion;Life;Measurement;Mediating;Memory;Mentors;Movement;Nervous System Disorder;neural;neural circuit;neural correlate;Neurocognitive;neuroimaging;Neurologic;neuromechanism;Neuronal Plasticity;object motion;oculomotor;Operative Surgical Procedures;orbit muscle;Outcome;Parietal;Parietal Lobe;Patients;Pattern;Pediatric Neurology;pediatric patients;Performance;Pharmaceutical Preparations;Population;pursuit tracking;Recovery;recruit;Resistance;Resolution;Resources;response;Role;Rotation;Saccades;sample fixation;Sampling;Scientist;Seizures;Short-Term Memory;Side;Site;skills;Smooth Pursuit;Structure;surgical risk;System;Task Performances;Temporal Lobe;Testing;Tissues;Training;Universities;Visual;visual information;Visual Perception;visual search;Visual System;visual tracking;Work;Writing

PROJECT_TITLE: Characterizing Eye Movements after Pediatric Cortical Resection: Neural Bases and Cognitive Implications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Directed evolution of CRISPR gRNA scaffolds at therapeutic targets will increase editing efficiency, and be high throughput tested via a lentiviral screen. Machine learning (ML) models will be trained using this data to predict optimal scaffolds at a global genomic level. This method will be applied to promising CRISPR systems.

PI_NAMEs: LLANGA, TELMO  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Academia;Acceleration;Address;base;Base Pairing;Base Sequence;Binding;career;Chemicals;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consumption;Data;deep learning;deep learning algorithm;deep learning model;Dependovirus;Development;Directed Molecular Evolution;DNA;Engineering;Evolution;Free Will;gene editing technology;Gene Targeting;gene therapy;Genes;Genetic Recombination;genome editor;Genomics;Guide RNA;Human Genome;immunogenicity;improved;in vivo;innovation;interest;Investigation;Kinetics;knockout gene;Libraries;Ligands;Machine Learning;machine learning model;Methods;Modeling;Modification;Mutagenesis;mutant;Mutation;novel;Nucleotides;Orthologous Gene;particle;Performance;Plasmids;Postdoctoral Fellow;prediction algorithm;predictive tools;Productivity;Proteins;rational design;Reporter;Resources;Ribonucleoproteins;Satellite Viruses;scaffold;Scanning;screening;Site;skills;Staphylococcus aureus;Streptococcus;Structure;synergism;System;Testing;Therapeutic;therapeutic target;Time;tool;Training;training data;Variant;vector;Viral

PROJECT_TITLE: CRISPR Guide RNA Exponential Directed Evolution Synergy with Machine Learning to Improve Gene Editing Efficiency

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative My proposal aims to delineate the different subtypes of cell death in eosinophils and characterize the pathophysiological impact of these cell death subtypes. I propose to use the most up to date criteria and definition for detecting cell death modality to further identify the different cell death types in eosinophils in response to different stimuli and monitor the impact of these cell death as it might relate to eosinophilic- associated diseases (EAD).

PI_NAMEs: OSUJI, IMMACULETA KASARACHI (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Accidents;Affect;Allergic Disease;ANXA5 gene;Apoptosis;Apoptosis Inhibitor;Applications Grants;Asthma;Automobile Driving;Biochemical;Biology;Blood;Calcium;Cardiac Myocytes;CASP3 gene;CD95 Antigens;Cell Death;Cell Death Signaling Process;Cell Differentiation process;Cell membrane;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Cessation of life;Coculture Techniques;Coupled;Cytolysis;Cytoplasm;Cytoplasmic Granules;Data;Disease;Disseminated eosinophilic collagen disease;eosinophil;eosinophilic asthma;Eosinophilic Gastrointestinal Disease;extracellular;FDA approved;Fibrosis;fighting;Functional disorder;Goals;Heart;Heart Diseases;Heart failure;High Prevalence;Histologic;Homeostasis;Hydrogen Peroxide;Immune response;Immune System Diseases;in vitro Model;in vivo Model;Incidence;Individual;Induction of Apoptosis;Infection;Inflammation;innovation;Ionophores;Lead;Leukocytes;Life Cycle Stages;Ligation;Measures;Mediating;Methods;Mitochondria;Modality;Modeling;Monitor;Morphology;mouse model;Mus;Myocarditis;Necrosis;new therapeutic target;novel;Organism;Outcome;Parasites;Pathogenesis;Pathogenicity;Pathology;Patients;Permeability;Persons;pharmacologic;Pharmacology;Physiology;Process;Proteins;recruit;response;Role;Signal Pathway;Signal Transduction;Site;Staurosporine;Stimulus;targeted treatment;Testing;Therapeutically Targetable;tissue regeneration;tissue repair;Tissues

PROJECT_TITLE: Pathophysiological impact of subtypes of eosinophil cell death

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative 97% of ALS patients and 57% of Alzheimer’s Disease patients present with dysregulation of the protein TDP-43, causing disruption of a variety of critical genes, leading to neurodegenerative disease. Neuroinflammation, an understudied facet of ALS and Alzheimer’s Disease, occurs when overactive immune cells cause catastrophic damage to otherwise healthy neuronal tissue. Using neuron/immune cell culture and a mouse model of TDP-43 pathology that exhibits a progressive neurodegenerative phenotype, this project aims to understand the genetic and molecular regulators of neuroinflammation and characterize potential therapeutic targets for ALS and Alzheimer’s Disease.

PI_NAMEs: O'CONNOR, JAMES T (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: ABHD12 gene;Age;ALS patients;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Axon;axonal degeneration;Bioinformatics;Biological Response Modifiers;Biomedical Research;Candidate Disease Gene;cell behavior;Cell Communication;Cell Culture Techniques;Cell membrane;Cells;Coculture Techniques;Communities;Data;Defect;Disease;disease phenotype;Down-Regulation;Eating;Equipment;Exhibits;extracellular;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Growth;Guide RNA;Heterozygote;Human;imager;Immune;immune activation;Immune signaling;Immunology;immunoregulation;Impairment;Individual;Inflammation;inhibitor;injured;Injury;insight;Institution;interest;Journals;Lead;lectures;Macrophage;Mediating;Messenger RNA;Microglia;Microscope;Modeling;Molecular;molecular marker;Motor;mouse model;Mus;Mutant Strains Mice;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuroimmune;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurons;neuropathology;neuroprotection;Neurosciences;novel;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Peptide Initiation Factors;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Phosphatidylserines;prevent;protein TDP-43;Proteins;Publishing;Research Personnel;Resources;RNA library;RNA Splicing;RNA-Binding Proteins;Science;Signal Transduction;success;symposium;Synapses;Testing;Therapeutic;therapeutic target;Time;tissue culture;Tissues;Universities;Viral;Washington

PROJECT_TITLE: Dissecting neuroinflammatory mechanisms in a model of progressive TDP-43 pathology


PHR: Project Narrative This project will create and test the efficacy in vivo of a novel T cell therapy to treat pulmonary fibrosis via TGF- β inhibitor payload delivery and profibrotic fibroblast depletion. T cells will co-express a Synthetic Intramembrane Proteolysis Receptor (SNIPR) and a Chimeric Antigen Receptor (CAR), both of which target profibrotic fibroblasts. The activation of the SNIPR circuit will drive the local secretion of TβRII-Fc to the fibrotic niche.

PI_NAMEs: WHITTY, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Adoptive Transfer;Adverse effects;Affinity;age related;Alveolar;alveolar epithelium;Antigens;Apoptosis;Apoptotic;Architecture;Automobile Driving;BCL-2 Protein;Binding;Bleomycin;Breeding;CAR T cell therapy;catalyst;cell killing;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Chronic Disease;Cicatrix;Collagen;Combined Modality Therapy;Complex;conflict resolution;cost;Cues;cytokine;Data;Deposition;design;Disease;DNA;dosage;Drug Delivery Systems;efficacy evaluation;efficacy testing;engineered T cells;Engineering;Extracellular Matrix Proteins;Extracellular Protein;FDA approved;Fibroblasts;Fibrosis;Flow Cytometry;Genetic;high risk;Homeostasis;Hydroxyproline;Immunofluorescence Microscopy;Immunoglobulin Fragments;In Vitro;in vivo;in vivo Model;Individual;Inflammation;inhibitor;interest;Laboratories;Lung;Lung Transplantation;Malignant Neoplasms;Measurement;Measures;Membrane;Modeling;Modification;mouse model;Mus;nintedanib;Non-Malignant;Normal tissue morphology;novel;Organ Donor;Patients;Performance;performance tests;Pharmaceutical Preparations;Phenotype;Pirfenidone;prevent;profibrotic fibroblast;programs;Progressive Disease;Proliferating;Proteins;Proteolysis;Pulmonary Fibrosis;Quality of life;receptor;receptor binding;Response Elements;Risk;Role;Safety;Signal Transduction;Site;Specificity;Structure of parenchyma of lung;T cell therapy;T-Cell Proliferation;T-Lymphocyte;Tamoxifen;targeted delivery;Techniques;Testing;TGFBR2 gene;therapeutic target;therapeutically effective;tissue injury;Tissues;Toxic effect;Transforming Growth Factor beta;Transplantation;Tyrosine Kinase Inhibitor;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: Adapting cell-based therapies for the treatment of pulmonary fibrosis


NIH_SPENDING_CATS: Infectious Diseases;Pediatric;Pregnancy

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Gamma delta T cells are unusual T cells that play important roles in the immune response in mucosal tissues. Some gamma delta T cell subsets develop and acquire function only in the fetal thymus. We will use a mouse model to understand how maternal infection and inflammation during pregnancy influences the fetal thymic development of gamma delta T cells, and whether maternal infection/inflammation can result in long-lasting changes in gamma delta cell function in offspring.

PI_NAMEs: BONNEY, ELIZABETH A. (contact);BOYSON, JONATHAN E

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adult;Affect;Autoimmunity;Birth;Cell Count;Cell Physiology;Cells;Cellular biology;clinically relevant;Communicable Diseases;Coupled;cytokine;D Cells;Data;Development;Disease susceptibility;Dose;Environment;Epigenetic Process;Exposure to;fetal;Fetal Development;Fetal Thymic Organ Culture;Fetus;Flow Cytometry;Genetic Transcription;Gestational Age;high dimensionality;Human;Immune;immune activation;immune function;Immune response;Immune system;Infection;Inflammation;Life;Ligands;Lipopolysaccharides;Lymphocytic Choriomeningitis;Lymphocytic choriomeningitis virus;Maternal-Fetal Exchange;Mediator;Modeling;mouse model;Mucous Membrane;Mus;Neonatal;neonate;novel;offspring;pathogenic virus;Phenotype;Placenta;placental infection;Play;Poly I-C;Population;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;protein expression;proteogenomics;Publishing;Reagent;Role;self-renewal;Shapes;Signal Induction;single cell ATAC-seq;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;thymocyte;Thymus Gland;Tissues;tool;transcription factor;transcriptome;tumor;Vertical Transmission;Viral;Virus Diseases;γδ T cells

PROJECT_TITLE: Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (55)]


ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Heart failure is a widespread and severe clinical outcome of poorly treated diabetes mellitus, and preliminary work has defined an association between diabetic heart disease, DNA methylation, and protein O- GlcNAcylation—(molecular marks implicated in the regulation of gene expression and protein function). However, while the possible downstream effector, Nox4, is upregulated upon long-term increased cardiac protein O-GlcNAc, the regulatory mechanism of Nox4 expression is understudied. This proposal aims to determine Nox4 regulation by DNA methylation, and Nox4’s necessity in the observed cardiac dysfunction during chronic enhanced O-GlcNAc.

PI_NAMEs: CHANG, SAMUEL FORMOSA (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Apoptosis;Automobile Driving;Biological Assay;Biology;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;career;Chromatin;Chronic;Clinical;clinical training;CpG Islands;Cytosine;Data;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;Diagnosis;Dioxygenases;Disease;DNA;DNA Methylation;DNA methylation profiling;DNA Methylation Regulation;DNA sequencing;DNA-Protein Interaction;Enzymes;Epigenetic Process;Fibrosis;field study;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Gene Proteins;Generations;Genes;Genetic;Genetic Materials;Germ Lines;Glucose;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;heart imaging;Heart Rate;Histones;Hypertrophy;in silico;Individual;insight;Knock-out;knockout gene;Knowledge;Link;Literature;Mediating;Medicine;Mentors;Modeling;Modification;Molecular;molecular pathology;Molecular Target;mortality;mouse model;Mus;Myocardial dysfunction;NADPH Oxidase;non-diabetic;novel;Nutrient;O-GlcNAc transferase;Outcome;Pathologic;Pathology;Pathway interactions;Physicians;Post-Translational Protein Processing;Precision therapeutics;Prevalence;prevent;promoter;protein function;Proteins;Reactive Oxygen Species;Regulation;Regulator Genes;Research;research and development;Resources;RNA;Role;Scientist;Signal Transduction;skill acquisition;skills;System;Techniques;Testing;therapeutic target;Tissues;Training;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Up-Regulation;Validation;Work

PROJECT_TITLE: Nox4 and Epigenetics in chronically enhanced cardiac protein O-GlcNAcylation


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Although elevated reactive oxygen species (ROS) have a well-documented association with a variety of disease pathologies, ROS also serve as key signaling molecules. Moreover, cardiac preconditioning has been effective in attenuating damage induced by ischemic injury, suggesting a beneficial role of ROS in priming cardiomyocytes for injury response. The goal of this proposal is to elucidate how diminished ROS during the initial neonatal mouse period impairs cardiomyocyte regeneration, as well as how lowered ROS levels during this period can delay metabolic maturation.

PI_NAMEs: WALKER, ALLISON TROUTEN (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acute;adeno-associated virus 9 delivery;Animal Model;Animals;Anterior;Antioxidants;artery occlusion;Automobile Driving;Biological Process;Birth;burden of illness;Calcium;Cardiac;Cardiac Myocytes;Cardiac Output;cardiac regeneration;Cell Cycle Arrest;Cell Death;cell type;Cellular Metabolic Process;Characteristics;Cicatrix;comparison control;conditioning;Culture Media;Cysteine;Data;Development;Developmental Process;Disease;DNA Damage;Dose;Echocardiography;Electrophysiology (science);Environment;Exhibits;extracellular;fatty acid oxidation;fatty acid supplementation;Fatty Acids;Fibrosis;field theory;Food;Future;Genes;Genus Hippocampus;Glycolysis;Goals;Heart;Heart failure;heart function;Hormones;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell derived cardiomyocytes;Injections;Injury;Ischemia;ischemic injury;Kinetics;knock-down;Knock-out;Left;Lentivirus;linoleates;Metabolic;Metabolism;Microscopy;Mitochondria;Modeling;mouse model;Mus;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Natural regeneration;Neonatal;neonatal mice;neonatal period;Oleates;Operative Surgical Procedures;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Oxygen Consumption;Palmitates;Pathologic;Pathology;Pharmacologic Substance;postnatal;postnatal period;preconditioning;Procedures;Process;Proliferating;Proliferation Marker;promoter;Public Health;pup;Reactive Oxygen Species;Recovery;regenerative;Regenerative capacity;Regulation;Research Proposals;response to injury;Role;Sarcomeres;sham surgery;Signal Pathway;Signal Transduction;Signaling Molecule;Source;Stress;Structure;Testing;theories;Therapeutic;Time;Tissues;transcriptome sequencing;Transfection;translocase;Trichrome stain;Troponin;Ventricular

PROJECT_TITLE: The role of neonatal ROS in cardiomyocyte maturation and injury response


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Infertility;Neurosciences;Sleep Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Globally, it is estimated that infertility affects approximately 10-15% of all couples trying to become pregnant, and while the exact cause of infertility is not always known, dysfunction in circadian timekeeping capacity likely plays a role in the inability to conceive. This research will examine whether time-of-day changes in sexual behavior influence reproductive success in mice and whether sexual behavior can be manipulated throughout the day to optimize fertility. Overall, this project may lead to a better understanding of the daily changes in sexual drive propensity and may help in the design of therapeutics for individuals with misaligned daily rhythms (shift workers, etc.) who are trying to conceive.

PI_NAMEs: ATEN, SYDNEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Acute;Affect;Aggressive behavior;Architecture;Arousal;Behavior;behavior influence;Behavioral;Behavioral Paradigm;Biochemical Process;Biological Rhythm;brain based;brain circuitry;Cells;Cholera Toxin;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Conceptions;Couples;Cues;Darkness;Data;design;Endocrine;Estrogens;Estrous Cycle;Event;experience;experimental study;Female;female fertility;Fertility;Foundations;Functional disorder;Gene Expression;Genes;Genetic;genetic approach;Hormones;Hour;Human;Hypothalamic structure;idiopathic infertility;Impairment;Individual;Infertility;Injections;Internal Ribosome Entry Site;knock-down;Label;Libido;Light;male;male fertility;male sex hormones;Mammals;mating behavior;Mediating;Mus;neural circuit;Neural Interconnection;Neurons;Neurosecretory Systems;neurotransmission;Output;Ovarian Cycles;Ovulation;Pacemakers;Partner in relationship;Pathway interactions;Periodicity;Peripheral;Persons;Physiological Processes;pituitary gonadal axis;postsynaptic;Pregnancy;pregnant;Production;Reproduction;reproductive;reproductive axis;Reproductive Behavior;reproductive function;reproductive outcome;reproductive success;Reproductive system;Research;Retina;Rodent;Seminal fluid;sex;Sex Behavior;Sexual Arousal;Sexual Reproduction;shift work;Signal Transduction;Sleep;Social Interaction;sperm cell;suprachiasmatic nucleus;System;Testing;Testosterone;Therapeutic;therapeutic target;Time;Tissues;Toxin;Translating;trying to conceive;Viral;Work

PROJECT_TITLE: Hypothalamic circuitry underlying the circadian control of sexual drive and reproduction


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE American Indian populations experience the highest burden of cardiovascular disease compared to any other racial/ethnic group in the US and thus may be particularly vulnerable to the adverse health effects of even low levels of air pollution; however, there is currently a lack of relevant data to comprehensively characterize the air pollution levels, components, and sources in American Indian and other rural populations. Leveraging the NIH- funded Strong Heart Study, we will characterize air pollution and its association with cardiovascular disease in American Indian populations in the Southwest and the Great Plains. This study in rural and American Indian communities will provide critical data that are currently missing to inform National Ambient Air Quality Standards, contributing key information needed to inform interventions and mitigation strategies to reduce air pollution exposures and improve overall health of vulnerable populations.

PI_NAMEs: HILPERT, MARKUS  (contact);KIOUMOURTZOGLOU, MARIANTHI-ANNA ;NAVAS-ACIEN, ANA

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acids;Address;Affect;Air;Air Pollution;ambient air pollution;Ambulatory Blood Pressure Monitoring;American Indian community;American Indian Population;American Indians;Area;Arizona;Blood Pressure;blood pressure elevation;Calibration;Carbon;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Chemicals;Clinical;cohort;Cohort Studies;Collection;Communities;Coronary heart disease;Data;Data Reporting;Database Management Systems;Dependence;Devices;Diabetes Mellitus;Disease Outcome;Environment;environmental disparity;Ethnic Population;experience;Exposure to;Family;fine particles;Funding;Gases;Great Plains;hazard;Health;Heart;Heart failure;Hour;Hypertension;improved;Intervention;light scattering;Literature;Long-Term Effects;Measurement;Measures;Metals;Modeling;modifiable risk;Modification;mortality;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;neighborhood disadvantage;Nitrogen Dioxide;North Dakota;Northern Plains;Oklahoma;Ozone;Participant;Patient Recruitments;Phase;Pollution;Population;Population Group;predictive modeling;Prevention strategy;Public Health;Pump;racial population;Recommendation;Reference Standards;Research;response;Risk;Rural;rural area;Rural Population;Sampling;Seasons;Site;Source;South Dakota;spatiotemporal;standard measure;Strategic Planning;Stroke;suburb;Time;Toxic effect;tribal community;Underrepresented Populations;United States Environmental Protection Agency;United States National Institutes of Health;urban area;Vulnerable Populations;World Health Organization

PROJECT_TITLE: Air Pollution and Cardiovascular Disease in American Indian Communities

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because it closes a major gap in knowledge on how similar incretins elicit starkly different signaling responses in primary beta () cells. This proposed study extends our current understanding of incretin signaling within primary  cells and integrates this with differences between incretin-mediated cAMP responses in  cells and the interplay of cAMP and Ca2+ dynamics that dictate the  cell secretory response to nutrient and incretin co-stimulation. The proposed research is relevant to NIDDK’s mission because it directly addresses the mechanisms by which incretins potentiate glucose-stimulated insulin secretion, which can be leveraged to improve therapies for millions of Americans with diabetes.

PI_NAMEs: CHAN, MICHELLE YING-YING (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Agonist;American;Arrestins;Automobile Driving;Beta Cell;Binding;Cells;Chemosensitization;Coupled;Cyclic AMP;Development;Diabetes Mellitus;Effectiveness;Exocytosis;Food Interactions;Functional Imaging;G-Protein-Coupled Receptors;gastric inhibitory polypeptide receptor;Generations;Genetic;GLP-I receptor;glucagon-like peptide 1;Glucose;Hypoglycemia;Image;improved;innovation;insight;Insulin;Insulin Resistance;insulin secretagogues;insulin secretion;islet;Kinetics;Knock-out;Knowledge;Mediating;Mission;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Outcome;pancreatic juice;Patient-Focused Outcomes;Patients;Perfusion;Phase;preference;Production;Public Health;receptor;Receptor Signaling;recruit;Recycling;Research;response;Risk;Second Messenger Systems;Secretory Cell;sensor;Shapes;Signal Transduction;Stimulus;synergism;Testing;Therapeutic;tool;trafficking;Transgenic Mice;Weight

PROJECT_TITLE: Mechanisms Driving the Kinetics of Incretin-Mediated Beta Cell Responses


PHR: The proposed research is relevant to public health because there is currently no clear consensus of the mechanism by which beta and delta cells coordinate their Ca2+ and hormone secretion in response to elevated blood glucose. The proposed mechanisms complement existing observations and link delta cells with distinct patterns of Ca2+ behaviors to specific mechanisms of coordination. The proposed research is relevant to NIDDK’s mission because it directly addresses the mechanism of beta-delta cell coordination, which is a crucial aspect of islet crosstalk to regulate insulin secretion that can be leveraged to improve the quality of life for millions of Americans afflicted with diseases of impaired glucose homeostasis.

PI_NAMEs: POURHOSSEINZADEH, MOHAMMAD S (contact)

PROJECT_TERMS: Acute;Address;Alpha Cell;American;Attenuated;Back;Behavior;Beta Cell;Biology;Blood Glucose;blood glucose regulation;Calcium;Calcium Oscillations;Calcium Spikes;cell behavior;Cell Communication;Cell secretion;Cells;Communication;comorbidity;Complement;Complex;connexin 36;Connexins;Consensus;Coupled;Coupling;D Cells;Data;design;Development;Diabetes Mellitus;Disease;Drug Design;Electrophysiology (science);Ensure;Exhibits;Feedback;Fluorescence-Activated Cell Sorting;GALR1 Galanin Receptor;Gap Junctions;Glucagon;Glucose;Heterogeneity;Hormone secretion;Hormones;Hyperglycemia;Hypoglycemia;Image;imaging approach;Impairment;improved;inhibitor;innovation;Insulin;insulin regulation;insulin secretion;intercellular communication;Investigation;islet;Islet Cell;Islets of Langerhans;Knowledge;Link;live cell imaging;Maintenance;Mediating;Minor;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutics;Outcome;Pancreas;paracrine;Paracrine Communication;Patch-Clamp Techniques;Pattern;Permeability;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Persons;pharmacologic;Physiologic pulse;Physiology;Play;prevent;Protein Isoforms;Public Health;Publishing;Quality of life;Reporter;Research;response;rho GTP-Binding Proteins;Role;Signal Transduction;Somatostatin;Stains;Testing;Time;Tissues;Tracer;transcriptome sequencing;urocortin;Visualization;Work

PROJECT_TITLE: Investigation of the Mechanism(s) of Beta and Delta Cell Coordination Under High Glucose


NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE This project will combine neuroimaging methods and advanced functional MRI techniques to study the role of the cerebellum in linguistic functions. We will examine how the cerebellum uniquely contributes to the comprehension of syntax in sentences using functional MRI. Findings from this work will improve our basic scientific understanding of the cerebellum’s core algorithmic capabilities, reveal the cerebellum’s potential range of neural computations, and provide insight into how a disruption in these processes may cause language and verbal working memory deficits in various disorders such as dyslexia, specific language impairment and autism.

PI_NAMEs: JOBSON, KATIE R (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Agrammatism;Algorithms;Applications Grants;autism spectrum disorder;Behavior;Behavioral Paradigm;Brain;Brain Stem;Broca's area;Calibration;Case Study;causal model;cerebellar lesion;Cerebellum;Cerebral cortex;Cerebrum;Child;Cognition;Cognitive;cognitive process;Communication;Comprehension;Computer Models;connectome;Data Set;design;Development;Disease;Dissociation;Dyslexia;Emotions;executive function;Fiber;frontal lobe;Functional Magnetic Resonance Imaging;Goals;Human;imaging study;Impairment;improved;Individual;insight;Knowledge;Language;language processing;Left;Lesion;Life;Linguistics;Link;Literature;Lobule;Memory impairment;memory process;Methods;Modeling;Motor;Movement;neural;neuroimaging;Neurons;neuropsychiatric disorder;nonhuman primate;novel;Output;Participant;Pattern;Play;Process;Psychophysics;Published Comment;Reporting;Research;response;Risk Factors;Role;Semantics;Short-Term Memory;social cognition;social communication;specific language impairment;Structure;syntax;Techniques;Testing;theories;tractography;Training;verbal;Work

PROJECT_TITLE: Language and the cerebellum


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Neurosciences;Pain Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative This project aims to investigate how thermo-tactile interactions drive human behavior by studying touch and temperature perception together. We will use centrally-mediated thermal illusions to determine if illusory thermal cues and illusory thermal pain modulate vibrotactile perception, providing insight into whether these interactions also occur centrally. Additionally, we will examine if primary somatosensory neurons encode cutaneous thermal information by analyzing the neural firing rates in response to vibrations under varying skin temperatures in non- human primates.

PI_NAMEs: RAMIREZ, JUAN CARLOS  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TITLE: Determining a Central Locus for Temperature Modulation of Touch Sensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Alterations in fat metabolism contribute to the etiology of multiple metabolic diseases that ultimately accounts for over 30% of mortality worldwide. The proposed research is designed to discover key mechanisms by which intestinal epithelial cells and microbiota respond to a high fat diet, and is expected to lead to increased understanding and new treatments for human diabetes, cardiovascular, and other metabolic diseases. The proposed research is therefore relevant to the part of NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: FARBER, STEVEN A (contact);RAWLS, JOHN F

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: absorption;Acinetobacter;Address;Animals;Apolipoproteins B;Automobile Driving;Award;Bile Acids;bile salts;burden of illness;Calcium;Cardiovascular system;Cell Communication;Cell Nucleus;Cell Physiology;cell type;Cells;Circulation;Communication;Cytoplasm;Data;design;Diabetes Mellitus;dietary;Dietary Fats;Digestive Physiology;Distal;Enterocytes;Enteroendocrine Cell;Epithelial Cells;Etiology;Exhibits;Family;Fatty acid glycerol esters;functional genomics;Funding;Gastrointestinal tract structure;Genes;Genetic;genetic analysis;genetic approach;Genetic Screening;Genetic Transcription;gut microbiota;Health;High Fat Diet;HNF4A gene;Hormones;host microbiota;Human;in vivo;in vivo imaging;innovation;Intestinal Absorption;intestinal epithelium;Intestinal Secretions;Intestines;Knowledge;lipid metabolism;Lipids;Lipoproteins;Mammals;Maps;Measures;Mediating;member;Metabolic Diseases;Methods;Microbe;microbial;microbial colonization;microbiota;Mission;mortality;Mus;mutant;neurotransmitter release;novel;Nutrient;Nutritional;Nutritional status;Organ;Organism;Pathway interactions;pharmacologic;Phenotype;Physiology;Play;Process;Production;Productivity;Protein Dynamics;Proto-Oncogene Proteins c-myc;Regulatory Pathway;Regulon;Reporter;Reporter Genes;Research;Resources;response;reverse genetics;Role;Sensory;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;System;Testing;Tissues;tool;Transcript;transcription factor;Transcriptional Activation;transcriptome sequencing;Transgenic Organisms;United States National Institutes of Health;uptake;Zebrafish

PROJECT_TITLE: Identifying genes required for digestive physiology and lipid metabolism

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]