NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes. The proposed study will evaluate SMS platform and reproductive health counseling intervention in a cluster randomized controlled trial among women receiving routine HIV care, and plan for future implementation with qualitative and health economic analyses.

PI_NAMEs: DRAKE, ALISON L (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Africa South of the Sahara;antiretroviral therapy;arm;Behavior;Behavioral;care providers;Caring;Climate;Clinic;Communication;Complex;Conceptions;Consolidated Framework for Implementation Research;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost;cost effective;cost effectiveness;cost estimate;Counseling;Data;Decision Making;design;Drug Interactions;economic evaluation;economic impact;Effectiveness of Interventions;empowerment;Enrollment;Ensure;Environment;Evaluation;experience;Face;Family Planning;Fertility;Focus Groups;future implementation;Goals;Health;health care service;health economics;health goals;Health Personnel;Health system;Health Technology;Healthcare Systems;healthy pregnancy;HIV;implementation barriers;implementation science;improved;internalized stigma;Intervention;intervention cost;Justice;Kenya;Life;Maternal and Child Health;Maternal-Child Health Services;mathematical model;Measures;meeting abstracts;meetings;Methods;mHealth;mhealth interventions;microcosting;Modeling;Mother-to-child HIV transmission;Motion;Motivation;novel;Outcome;patient level intervention;Pharmaceutical Preparations;Planned Pregnancy;Population;postpartum contraception;Pregnancy;pregnancy prevention;prevent;Prevention;programs;Provider;Randomized, Controlled Trials;Readiness;reproductive;Reproductive Health;Reproductive Health Services;Resource-limited setting;Resources;Rights;Risk;secondary outcome;Self Efficacy;service delivery;Services;side effect;Site;skills;standard of care;STI prevention;Surveys;Testing;texting support;theories;Time;tool;Training;treatment arm;Treatment Protocols;two way texting;unintended pregnancy;Viral;Woman;Women's trial

PROJECT_TITLE: Mobile WACh Empower:  Mobile solutions to empower reproductive life planning for women living with HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SOCIAL SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  While in utero ethanol exposure causes a well-described complex of conditions, there is also mounting evidence and concerns that some outcomes, including reproductive outcomes, are also detectable in the third generation following initial exposure. However, how a memory of ethanol exposure is initiated and then transmitted to future generations is currently not well understood. Our work will identify the epigenetic and metabolic underpinnings of ethanol’s transgenerational reproductive effects which will lay out a strong foundation for the implication of these pathways in a human context.

PI_NAMEs: ALLARD, PATRICK  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Acetylation;Address;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;alcohol testing;Alcohols;Apoptosis;Automobile Driving;behavioral impairment;Binding;Biological Models;Brain;Caenorhabditis elegans;Child;Chromatin;Chromosome Pairing;Cleavage Under Targets and Release Using Nuclease;Complex;Cytology;Data;Defect;design;Disease;Drosophila genus;Embryo;Environment;Environmental Exposure;Environmental Impact;Epigenetic Process;epigenome;epigenomics;Ethanol;Ethanol Metabolism;Event;Exposure to;fetal;Fetal Alcohol Exposure;Fetal Alcohol Syndrome;Foundations;Functional disorder;Future Generations;Generations;Genetic;Genetic Recombination;Genome;Germ Cells;Germ Lines;Goals;Heritability;Histone Acetylation;histone modification;Histones;homologous recombination;Human;Incidence;Knowledge;Link;Mammals;Maps;Mass Spectrum Analysis;Mediator;Meiosis;Memory;Metabolic;Metabolic Pathway;model organism;Modeling;Modification;Molecular;Morphology;Mus;Nematoda;neurobehavioral;Neurologic;Nuclear;Organism;Outcome;Pathway interactions;pharmacologic;Physiological;Post-Translational Protein Processing;preference;Pregnancy;prenatal exposure;programs;Rattus;Regulation;Reporting;Reproduction;reproductive;reproductive function;Reproductive History;reproductive outcome;Research;Rodent Model;Seminal;stem;Symptoms;Testing;Tissues;tool;transgenerational epigenetic inheritance;transmission process;Western Europe;Woman;Work

PROJECT_TITLE: Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunction

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance Previous interventions have not focused on social network overdose prevention approaches for people who use opioids (PWUO). However, bystanders of an overdose include people who use and do not use opioids. Developing and evaluating programs to train PWUO to diffuse overdose prevention strategies to their network members can reduce community-level drug overdoses.

PI_NAMEs: LATKIN, CARL A (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Attention;barrier to care;Behavior;behavioral response;Caring;Characteristics;Collection;Communication;Communities;COVID-19 pandemic;Data;Data Analyses;design;Diffuse;Diffusion;Drug usage;Drug user;Education;Educational Intervention;effectiveness evaluation;Effectiveness of Interventions;Event;experience;Exposure to;fentanyl contamination;Future;Geography;Helping to End Addiction Long-term;Heroin;high risk;implementation framework;implementation intervention;indexing;Individual;insight;internalized stigma;Intervention;Interview;Literature;Location;Longitudinal Studies;medication for opioid use disorder;member;Mental Depression;Mental Health;mHealth;mortality;Naloxone;naloxone carriage;non-drug;opioid user;outreach;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;Participant;Pathway interactions;peer;Persons;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;prevent;Prevention approach;Prevention strategy;preventive intervention;programs;Psychological Factors;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;Research Design;residence;response;Risk;social;social factors;Social Network;social situation;social stigma;standard of care;Stigmatization;suicidal;therapy design;Time;Training;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: A social diffusion fatal overdose prevention intervention: Assessing the effectiveness of people who use opioids as peer educators in training using & non-using networks on overdose & stigma reduction

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Lung

ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PI_NAMEs: CHOUDHARY, GAURAV  (contact)

PROJECT_TERMS: Applications Grants;Area;Award;base;bench to bedside;Biology;Biomedical Engineering;Blood Vessels;Caliber;Cardiology;Cardiometabolic Disease;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;career;career networking;Centers of Research Excellence;Collaborations;Coupled;Data;Development;Discipline;early-career faculty;Engineering;Environment;experience;Exposure to;Extramural Activities;Faculty;Faculty Recruitment;formative assessment;Funding;Goals;Grant;Heart Diseases;Hospitals;Human;Infrastructure;innovation;Institution;inter-institutional;interest;International;Investigation;Lung;Lung Diseases;Manuscripts;Medical center;Medicine;Mentors;Mentorship;National Heart, Lung, and Blood Institute;novel;Oceans;Phase;Pilot Projects;Postdoctoral Fellow;Process;programs;Publications;Publishing;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Respiratory Disease;Respondent;Rhode Island;Scientist;Services;Structure;success;Surveys;Techniques;Testing;Translating;Universities;Vocational Guidance

PROJECT_TITLE: Pilot Projects Program


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Lung;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Systemic fungal infections represent a significant and growing public health problem. In the United States, invasive fungal infections are now one of the 10 leading causes of death (7th) even ahead of mortality due to tuberculosis. Our proposal addresses the significant gap in knowledge in understanding the genetic basis of variation in human immune response and susceptibility to inhaled fungal infection.

PI_NAMEs: KLEIN, BRUCE STEVEN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;African American population;Alleles;American;anti-fungal agents;arm;Binding;Blastomyces dermatitidis;Blastomycosis;Blood;Cause of Death;CD4 Positive T Lymphocytes;Cell Nucleus;Cells;Chromatin;chromatin remodeling;Communicable Diseases;congenital immunodeficiency;COVID-19;Cytosol;Data;Defect;Development;Disease;Disease Outbreaks;Environment;Epidemic;Equilibrium;ethnic difference;Ethnic Origin;European;European ancestry;Exposure to;Filipino;Funding;fungus;Gene Expression;Gene Expression Regulation;gene function;General Population;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Genome;genome sequencing;Haplotypes;Hepatitis B Virus;Hispanic Populations;Histoplasmosis;Human;IL17 gene;IL6 gene;Immune;Immune response;Immune Response Genes;Immunity;Impairment;in vivo;Individual;induced pluripotent stem cell;Infection;infection rate;Inflammatory;Influenza;Inhalation;Inherited;insight;Interferon Type II;Interleukin-12;Interleukin-6;Knowledge;Link;Linkage Disequilibrium;Location;Lung;Lung infections;Mediating;memory CD4 T lymphocyte;Microbe;MicroRNAs;Modeling;Molecular;mortality;Mus;Mycoses;Names;Native Americans;NF-kappa B;nuclear factors of activated T-cells;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Phenotype;Population;Positioning Attribute;Predisposition;Production;Public Health;Race;racial difference;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resistance;response;Risk;Shapes;single-cell RNA sequencing;stem;Study Section;T cell response;T-Lymphocyte;Testing;transcription factor;Translating;Tuberculosis;United States;Untranslated RNA;Vaccinated;Variant;whole genome;Wisconsin;Work

PROJECT_TITLE: Molecular pathogenesis of blastomycosis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Primary Health Care;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PI_NAMEs: SALLOUM, RAMZI GEORGE (contact)

PROJECT_TERMS: Address;Adopted;Adult;Advocacy;anti-cancer research;Area;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivorship;Caring;Catchment Area;Censuses;Cervical;Cervical Cancer Screening;Child;citizen science;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;Colorectal;colorectal cancer screening;Communities;community advisory board;community empowerment;community engagement;community involvement;Community Outreach;Counseling;County;COVID-19;Data;Data Reporting;Death Rate;Dedications;Disparity;Education;Education and Outreach;Enrollment;Ethnic Origin;Event;evidence base;Evidence based intervention;Faculty;farm worker;Florida;Funding;Future;Goals;Health;health equity;health equity promotion;Hispanic Populations;Home;human old age (65+);Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation facilitation;improved;Incidence;Individual;Intervention Trial;Leadership;life span;Link;Logic;Low income;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medically Underserved Area;member;Minority;Modeling;Monitor;mortality;mortality disparity;Multiple Myeloma;older adult;outreach;outreach clinics;Patients;Persons;Policies;Policy Developments;Policy Maker;Population;Poverty;Prevention;programs;Race;Recommendation;Research;Research Personnel;Resources;Retirement;Risk Factors;Risk Reduction;Rural;rural area;rural counties;Scientist;screening;Screening for cancer;self testing;skin cancer prevention;Smoker;social health determinants;socioeconomics;Stomach;Strategic Planning;Sun Exposure;survivorship;Terminology;Tobacco;tobacco prevention;Tobacco use;Tobacco Use Cessation;Tobacco-Related Carcinoma;Training;Translating;treatment trial;Underserved Population;Unemployment;Uninsured;Universities;uptake;Uterine Cancer;Woman;Work

PROJECT_TITLE: Community Outreach and Engagement

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative: Young people living with HIV in adolescence through emerging adulthood (ages 16-28 years) have the lowest rates of regular engagement in HIV care and adherence to HIV medications of any age group, with Black and Latinx individuals experiencing the greatest barriers to favorable HIV health outcomes. To provide a detailed understanding of the factors that promote or impede HIV management in this group, we will follow Black and Latinx youth/emerging adults living with HIV, half with optimal HIV health outcomes at enrollment (undetectable HIV viral load) and half without, for 18 months. Participants will engage in structured assessments, in-depth qualitative interviews, real-time ecological momentary assessments in two-week bursts, and biological tests (HIV viral load tests, drug tests), and a Youth Advisory Board comprised of youth living with HIV will help interpret findings in order to inform new policies, health care service practices, and interventions.

PI_NAMEs: GWADZ, MARYA  (contact);WILTON, LEO

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Adherence;Adolescence;Adult;African American;Age;age group;Alcohol consumption;American;antiretroviral therapy;Appointment;Behavior;Behavioral;Biological Markers;Biological Testing;Biometry;Black Populations;Black race;Caring;Cognitive;Continuity of Patient Care;Data;design;Development;Diagnosis;drug testing;Drug usage;Ecological momentary assessment;emerging adult;emerging adulthood;Enrollment;Epidemic;experience;Family Relationship;follow-up;Health;health care service;health care settings;Health Services;Healthcare;high risk;HIV;HIV risk;Homophobia;Hybrids;Individual;innovation;Intervention;Interview;Knowledge;Latinx;Latinx population;Literature;longitudinal design;Longitudinal Studies;longitudinal, prospective study;low socioeconomic status;Medical;Mental Health;Methods;microsystems;Minority;Modeling;Motivation;New York City;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;Policies;policy recommendation;Population;primary outcome;Process;prospective;protective factors;psychologic;Public Health;racism;Recommendation;recruit;Reporting;Research;Resources;Risk;Sampling;secondary outcome;Services;Sexual and Gender Minorities;social;Social Interaction;Social Network;Structure;substance use;substance use treatment;Testing;theories;therapy adherence;Time;United States;United States National Institutes of Health;Viral;Viral Load result;Vulnerable Populations;Youth

PROJECT_TITLE: Advancing knowledge on factors that promote or impede engagement along the HIV care continuum over time: A longitudinal mixed methods study of Black and Latinx youth/emerging adults living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PI_NAMEs: WINN, ROBERT A. (contact)

PROJECT_TERMS: Accountability;Accounting;Administrator;anti-cancer research;Area;Award;Basic Science;Budgets;Businesses;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer health equity;cancer research center director;Clinical;Clinical Cancer Center;Clinical Trials;Collaborations;Communication;Communities;community center;community engagement;Community Outreach;cost;Data Reporting;Development;diversity and inclusion;Ensure;equity, diversity, and inclusion;Evaluation;Event;expectation;experience;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Funding Agency;Funding Mechanisms;Funding Opportunities;Goals;Grant;Growth;Health;Hearing;Human Resources;improved;Individual;Informatics;Information Systems;Information Technology;Institution;inter-institutional;Leadership;Malignant Neoplasms;Maps;meetings;member;Mission;Modeling;Monitor;National Cancer Institute;operation;Outcome;Persons;Policies;Positioning Attribute;Process;Productivity;programs;Publications;Qualifying;Recovery;recruit;Reporting;Research;research faculty;Research Proposals;Resource Sharing;Resources;satisfaction;Scientist;Services;Strategic Planning;Strategic vision;Structure;Students;symposium;synergism;timeline;tool;Training and Education;translational engagement;Universities;Virginia;virtual;virtual platform;Vision;Voice;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE The proposed study will contribute to developing useful methods to identify people at high long-term risk of ADRD early in their midlife and to understanding the shared etiologies of sensory and cognitive changes. This project’s results will inform about potential pathways for prevention of ADRD to promote healthy brain aging.

PI_NAMEs: MERTEN, NATASCHA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Age;age acceleration;age related;Age Years;Aging;aging biomarker;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Auditory;Biological;Biological Markers;Blood;Blood specimen;Blood Vessels;blood-based biomarker;cardiovascular risk factor;Caregivers;Chronic;Chronology;Clinical;Cognition;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;Consensus;Contrast Sensitivity;cost effective;Data;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;Digit structure;disability risk;Disease;early detection biomarkers;Early Diagnosis;Environmental Risk Factor;epidemiology study;Etiology;Evaluation;follow-up;Future;General Population;glucose metabolism;Hearing;Hearing Tests;Heart Diseases;high risk population;Impaired cognition;Impairment;Inflammation;Interview;late life;lifestyle factors;liver function;Longitudinal cohort study;Longterm Follow-up;Measures;Medical History;Medical Records;mental state;Metabolic;Methods;middle age;Morbidity - disease rate;mortality;multidisciplinary;Nephrosis;Nerve Degeneration;Neurocognitive;novel;Odors;offspring;older adult;ophthalmic examination;Otoscopy;Participant;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Physiological;pre-clinical;Predictive Value;prevent;prospective;Protocols documentation;Questionnaires;Renal function;Research;response;Risk;Role;Screening procedure;Sensory;Sensory impairment;Smell Perception;Standardization;symposium;System;Taste Perception;tau Proteins;tau-1;Testing;Time;Trail Making Test;verbal;Verbal Learning;Vision;Visit;Visual Acuity

PROJECT_TITLE: The Beaver Dam Offspring Study Neurocognitive Aging Study (BOSS-NCAS)-A Study on the Role of Accelerated Aging and Midlife Sensory Decline for Early Alzheimer’s Disease and Dementia in Later Life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Diabetic retinopathy blinds approximately 12% of diabetic patients each year and its incidence is expected to increase. While there are currently no therapeutic strategies directed at its early stages, there is accumulating evidence that retinal photoreceptors are involved in the pathogenesis of diabetic retinopathy and are major contributors to diabetes-induced local inflammation in the retina. This project aims to study the responses of photoreceptors to hyperglycemia and interventions that address this pathway with the potential to be effective in the early stages of diabetic retinopathy to prevent the development of vision-threatening pathology.

PI_NAMEs: DE LA HUERTA, IRINA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adult;Age;Animal Model;authority;Automobile Driving;Award;Biological Assay;Biostatistical Methods;Blindness;Blood Vessels;Cell Nucleus;cell type;Cells;Cellular biology;clinical training;collaborative environment;cytokine;Data;Development;Diabetes Mellitus;diabetic patient;Diabetic Retinopathy;Disease;Doctor of Medicine;Doctor of Philosophy;Enterobacteria phage P1 Cre recombinase;experience;Exposure to;Functional disorder;Funding;Genes;Glucose;Goals;Hyperglycemia;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;Interleukin-1 alpha;Intervention;Knockout Mice;loss of function;Mediating;Mediator;medical schools;Mentors;Mentorship;Metabolic;monolayer;mouse model;Muller's cell;Mus;Neural Retina;Neuroglia;Neurosciences;nuclear factors of activated T-cells;Pathogenesis;Pathologic Processes;Pathology;Pathway interactions;Permeability;Photoreceptors;Physicians;Prevalence;prevent;Primary Cell Cultures;Principal Investigator;Process;Production;programs;promoter;Protein Isoforms;Proteins;Research;Research Personnel;response;Retina;Retinal Diseases;Retinal Photoreceptors;Rhodopsin;Risk;Role;Scientist;Severities;skills;Small Interfering RNA;Specialist;Streptozocin;Structure of retinal pigment epithelium;Surgeon;Techniques;Testing;Therapeutic;TNF gene;Training;transcription factor;United States;United States National Institutes of Health;Universities;Vascular Diseases;Vascular Endothelial Cell;vision development;Work

PROJECT_TITLE: Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Alcoholism remains a leading cause of death and disability, in need of new therapeutic interventions. The proposed research will focus on innovative approaches to inhibiting the enzyme catechol O-methyltransferase (COMT), which has been linked to alcohol use disorder (AUD), and could provide a new pathway for addressing this devastating disease.

PI_NAMEs: COHEN, SETH M (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;Active Sites;Acute;Address;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcoholism;alcoholism pharmacotherapy;Animal Model;attenuation;Binding;biophysical techniques;Biophysics;Brain;Catechol O-Methyltransferase;Catecholamines;Catechols;Cause of Death;Central Nervous System;Chronic;Clinical;Clinical Treatment;Cognition;cognitive control;cost;Decision Making;Dependence;Development;disability;Disease;Docking;Dopamine;drug discovery;Drug Kinetics;Enzyme Inhibition;Enzymes;Ethanol;experience;Family;FDA approved;functional group;Goals;Hepatotoxicity;Hormones;Hyperalgesia;Impaired cognition;improved;Impulsivity;Individual;inhibitor;innovation;Intake;Ions;Lead;lead series;Length;Libraries;Link;loved ones;Membrane;Mental Depression;metalloenzyme;Metals;Methylation;Modeling;Neurotransmitters;novel;novel therapeutic intervention;Parkinson Disease;Pathway interactions;Patients;Peripheral Nervous System Diseases;pharmacophore;Prefrontal Cortex;Procedures;programs;Property;Rattus;Regulation;Relapse;Research;Safety;sex as a biological variable;side effect;Signal Transduction;small molecule inhibitor;Societies;Stress;structural biology;Therapeutic;tolcapone;trait;Withdrawal;Xenobiotics

PROJECT_TITLE: Fragment-based Discovery of COMT Inhibitors as a Novel Pharmacotherapy for Alcoholism

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: LICHT, JONATHAN D. (contact)

PROJECT_TERMS: Abbreviations;Address;Advocacy;Aging;anti-cancer research;Award;Basic Cancer Research;Biology;Biomedical Research;Blood;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Catchment Area;CCL21 gene;Clinical;clinical care;clinical investigation;Clinical Research;Clinical Trials;Collaborations;college;Communication;Development;Direct Costs;Disease;Enrollment;Epigenetic Process;Extramural Activities;Faculty;flexibility;Florida;Fostering;Funding;Funding Mechanisms;Grant;Growth;Health;host microbiota;Immune response;Immunotherapy;innovation;Institution;Intervention;Intervention Trial;investigator-initiated trial;Investments;Last Name;Leadership;Lung;Malignant Neoplasms;Measures;Medicine;member;Mission;NCI Center for Cancer Research;NCI-Designated Cancer Center;novel;Outcome;participant enrollment;patient engagement;Peer Review;Policies;Population;population based;Population Sciences;prevent;Productivity;programs;Publications;Qualifying;recruit;Research;Research Personnel;Research Proposals;RNA;Role;Science;Site;Solid Neoplasm;Source;Strategic Planning;targeted treatment;Testing;Time;Tobacco Use Cessation;translational scientist;treatment response;tumorigenesis;Underrepresented Minority;Universities;Woman

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Pediatric;Prevention

PI_NAMEs: SARKAR, DEVANAND  (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Advisory Committees;American Cancer Society;anti-cancer research;Automobile Driving;Award;biobehavior;Bioinformatics;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;career;career development;clinical care;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Collaborations;community engagement;curriculum development;Dedications;Development;Discipline;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational Status;Equity;Evaluation;Event;experience;Extramural Activities;Faculty;faculty mentor;Female;Foundations;Funding;girls;Goals;Grant;health disparity;health equity;Healthcare;high school;Historically Black Colleges and Universities;improved;Individual;Informatics;Infrastructure;innovation;Institution;Investments;junior high school;K-Series Research Career Programs;Lead;Leadership;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Minority Groups;Molecular Medicine;NCI Center for Cancer Research;next generation;Oncology;oncology program;Outcome;Pathway interactions;Postdoctoral Fellow;pre-doctoral;prevent;Process;programs;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Training;Science;Scientist;service coordination;skills;Students;Teacher Professional Development;Training;Training and Education;training opportunity;Translational Research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Virginia;Work;Youth

PROJECT_TITLE: Cancer Research Training and Education Coordination (CRTEC)


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HIGHLAND HEIGHTS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHERN KENTUCKY UNIVERSITY

ORG_STATE: KY

PHR: 8. Project Narrative The use of antipsychotic drugs in pediatric populations has increased dramatically over the past 30 years despite a lack of basic research documenting the effects of these drugs on brain and behavioral development. This research will use laboratory rats to ascertain whether early-life antipsychotic drug administration leads to greater behavioral and neural sensitivity to opioid drugs in adulthood. This research will provide scientists, policy-makers, and practitioners with critical information regarding the impact of prolonged antipsychotic drug treatment during development on the risk of substance abuse in later life, as well as offer transformative research experiences in neuroscience to college undergraduates in Kentucky hailing from groups underrepresented in biomedical science.

PI_NAMEs: BARDGETT, MARK EDWARD (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Adult;Affect;age related;Amphetamines;Antipsychotic Agents;Attention deficit hyperactivity disorder;Award;Basic Science;Behavioral;Bioinformatics;Biomedical Research;boys;Brain;Brain region;Child;Childhood;Collaborations;college;conditioned place preference;conditioning;Control Groups;Core Facility;Data;Development;Dextroamphetamine;Disease;Disruptive Behavior Disorder;Dopamine;Dopamine Agonists;Dopamine Receptor;dopamine transporter;Dose;Drug Exposure;drug of abuse;Environment;Exhibits;experience;Extinction;FOS gene;Funding;Genetic;Genetic Transcription;Geographic Locations;girls;Goals;Grant;Health Sciences;high risk;Hyperactivity;Immediate-Early Genes;Injections;Institution;Kentucky;Label;Laboratory Rat;late life;Life;Long-Term Effects;member;Mental disorders;Mentors;Messenger RNA;Metabolic;model organism;Modification;mRNA Expression;neural;Neurons;Neurosciences;Neurotransmitter Receptor;next generation;Nucleus Accumbens;Opioid;opioid overdose;opioid use;Outcome;Oxycodone;Paper;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Policy Maker;Population;postnatal;programs;Prosencephalon;Psychology;psychostimulant;Publishing;Rattus;Reporting;Research;Research Project Grants;Research Support;Resources;response;Rewards;Risk;Risperidone;Science;Scientist;Series;Short-Term Memory;Students;Substance abuse problem;Synapses;Techniques;Technology;Time;Tissue Sample;Training;Transcript;transcriptome sequencing;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Brain Development after Early-Life Antipsychotic Treatment


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Lung;Natural Products;Nutrition

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Incidence and prevalence of Chronic obstructive pulmonary disease (COPD) in the United States is increasing steadily and has recently become a third leading cause of death in the U.S. Quercetin a dietary chemical found in foods such as apples and onions is a natural product with potential anti-COPD properties, but its therapeutic effects in COPD are not studied. This research will help us determine whether quercetin reduces inflammation without having side effects in COPD. This study will also provide necessary information for future treatment studies with quercetin for COPD.

PI_NAMEs: MARCHETTI, NATHANIEL ;SAJJAN, UMADEVI SIVANAPPA (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Adrenal Cortex Hormones;Agonist;Allium cepa;anti-cancer;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Antioxidants;Apple;Asthma;Biological;Biological Availability;Biological Process;Blood;Blood Glucose;Bronchial Hyperreactivity;Bronchoalveolar Lavage;Cause of Death;Chemicals;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Trials;clinically relevant;comorbidity;Data;design;Development;Diet;dietary;Disease;disease natural history;disease phenotype;dosage;Dose;efficacy evaluation;Environmental Risk Factor;epidemiology study;Epithelium;Flavonoids;Food;Future;Goals;Human;Immune response;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;influenza pneumonia;Inhalation;Lung;Lung Diseases;Measures;metabolic profile;meter;MicroRNAs;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Mus;Natural Products;novel;novel therapeutics;Oral;Outcome;Oxidants;Oxidative Stress;Participant;Pathway interactions;patient population;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physical Examination;Placebos;Plants;Plasma;Platelet Count measurement;Play;Pre-Clinical Model;Prevalence;prevent;Property;Protease Inhibitor;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Pulmonary Sarcoidosis;Quercetin;Questionnaires;Randomized;Research;Rhinovirus;Risk;Role;Running;Safety;safety assessment;side effect;Smoking History;Structure of parenchyma of lung;Supplementation;Symptoms;Therapeutic Effect;Tissue-Specific Gene Expression;Tissues;United States;volunteer

PROJECT_TITLE: Impact of quercetin on inflammatory and oxidative stress markers in COPD

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: MADORE, STEVEN JAMES (contact)

PROJECT_TERMS: Abbreviations;anti-cancer research;Area;Artificial Intelligence;Award;Basic Science;Biometry;Biotechnology;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genomics;Capital;career development;CCL21 gene;Clinical Cancer Center;Clinical Sciences;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;college;Complex;Confocal Microscopy;cost effective;Cost Savings;Cytometry;design;Development;Direct Costs;Doctor of Philosophy;Effectiveness;Ensure;Epigenetic Process;equipment acquisition;experience;Experimental Designs;Faculty;federal policy;Feedback;first-in-human;Florida;Flow Cytometry;Funding;Future;Genetic Research;genomic data;Goals;Grant;Health;Hour;Immune response;Immunologist;Immunophenotyping;Immunotherapy;Informatics;Infrastructure;Institution;Institutional Policy;instrument;instrumentation;Investments;Laboratories;Last Name;Leadership;Libraries;machine learning method;Malignant Neoplasms;member;microbiome;Microscopy;Monitor;new technology;next generation sequencing;novel;Peer Review;Peer Review Grants;Policies;Population Sciences;Postdoctoral Fellow;power analysis;Procedures;Process;programs;Publications;Quality Control;Reagent;recruit;Reproducibility;Research;research facility;Research Priority;research study;Research Support;Resource Sharing;Resources;response;RNA vaccine;Robot;Role;Science;screening;service member;Services;Strategic Planning;Surveys;System;Technology;Testing;Text;Therapeutic;Training;transcriptome sequencing;transcriptomics;Translational Research;treatment response;tumor;tumorigenesis;ultra high resolution;Universities;Update;vaccine trial;Wages

PROJECT_TITLE: Shared Resources Management


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TAYLOR, EMMANUEL A. (contact)

PROJECT_TERMS: Address;American Association of Cancer Research;anti-cancer research;Association of American Cancer Institutes;Automobile Driving;Biomedical Research;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;cancer research center director;career;career development;Caring;Catchment Area;Climate;Collaborations;community engagement;Community Outreach;Complex;Conscious;Diverse Workforce;Effectiveness;empowerment;Ensure;Equity;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Funding;Gender;Generations;Geography;Goals;harassment;Health;health equity;higher education;Human Resources;improved;Individual;Inequity;innovation;Institution;Leadership;leadership development;Letters;Malignant Neoplasms;member;men;Methodology;Minority;minority investigator;Minority-Serving Institution;Monitor;National Cancer Institute;novel strategies;Oncology;operation;Pathway interactions;Policies;Population;Process;programs;Race;recruit;Reporting;Research;Science;Scientist;sex;Social Justice;socioeconomics;Strategic Planning;Stress;Students;supportive environment;Surveys;synergism;Talents;Training and Education;unconscious bias;Underrepresented Minority;Underrepresented Populations;Universities;Virginia;Voice;Woman;Work;Workforce Development;Workplace

PROJECT_TITLE: Plan to Enhance Diversity (PED)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Nanotechnology;Sepsis

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The main goal of this research project is to deliver an amplification-free, microfluidic system integrating single cell pathogen identification (ID) and antibiotic susceptibility testing (AST) directly from whole blood for rapid diagnosis of bloodstream infection.

PI_NAMEs: WONG, PAK KIN ;YANG, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Adopted;Anti-microbial susceptibility;Antibiotic susceptibility;Antibiotics;Bacteria;Bar Codes;Biological;Biological Assay;Blood Cells;Blood specimen;Cells;Characteristics;Classification;Clinical;Collaborations;commensal microbes;commercialization;Computer software;Cytology;Cytolysis;Data;Data Analyses;design;Detection;Diagnosis;Diagnostic;diagnostic platform;Disease;Drug Controls;drug resistant pathogen;Electroporation;empowerment;Evolution;fungus;Goals;Growth;Hour;image processing;imaging system;improved;Individual;Industry;innovation;Kinetics;Label;Life;Measures;Membrane;Metabolism;Methods;Microbe;microbial;Microfluidic Microchips;Microfluidics;Microscopy;microwave electromagnetic radiation;Minimum Inhibitory Concentration measurement;Modality;Molecular;Molecular Probes;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multimodality;Nanotubes;novel;optical imaging;pathogen;Pathogen detection;Patients;Performance;Phenotype;precision medicine;Predisposition;Process;product development;prospective;Protocols documentation;rapid diagnosis;Research Personnel;Research Project Grants;Resistance;Resolution;response;Ribosomal RNA;RNA, Ribosomal, 18S;Sampling;Scheme;Science;Sepsis;single cell analysis;Sorting;Speed;System;Techniques;Technology;Temperature;Testing;Time;time use;Translating;Triage;Validation;validation studies;Vertebral column;Whole Blood

PROJECT_TITLE: Changing Cultures in Sepsis: Rapid single-cell pathogen identification and antibiotic susceptibility testing directly from whole blood

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (UNIVERSITY OF MONTREAL HOSPITAL)

ORG_STATE: PQ

ORG_ZIPCODE: H2X 0A9

PHR: Loss of vision in glaucoma results from the death of retinal ganglion cells (RGCs), the neurons that convey visual information from the retina to the brain. RGC dendrites, the fine processes that connect neurons within the retina, retract soon after glaucomatous injury. Here, we propose to investigate underlying mechanisms and strategies that promote RGC dendrite regeneration leading to cell-cell communication and restoration of neuronal function.

PI_NAMEs: DI POLO, ADRIANA  (contact);FORTUNE, BRAD

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;Adenosine Monophosphate;Automobile Driving;axon regeneration;Axotomy;Blindness;Brain;Cell Communication;cell injury;Cell Physiology;Cells;Cessation of life;clinical candidate;clinical development;Clinical Trials;Clinical Trials Design;Complex;Cytoskeleton;Data;Dendrite Regeneration;Dendrites;Disease;efficacy validation;Electrophysiology (science);experimental study;FRAP1 gene;Functional disorder;functional restoration;gain of function;gene therapy;Glaucoma;Goals;high intraocular pressure;Impairment;in vivo imaging;Injury;innovation;insight;Insulin;insulin signaling;Knowledge;knowledge translation;loss of function;Magnetism;Mediating;Mediator;Microspheres;Modeling;Monitor;Mus;Natural regeneration;neuron loss;Neuronal Dysfunction;Neurons;nonhuman primate;novel;Ocular Hypertension;Onset of illness;Optic Nerve;Outcome;Pathologic;Pathology;Patients;Positioning Attribute;pre-clinical;pressure;Process;Protein Kinase;Proteins;Recovery;regenerative;regenerative approach;Regenerative response;Regulation;repaired;restoration;Retina;retinal ganglion cell regeneration;Retinal Ganglion Cells;retinal neuron;Risk Factors;Role;Safety;sensor;sight restoration;Symptoms;Synapses;Techniques;Testing;Therapeutic;Time;translational potential;Translations;Vision;visual information;Work

PROJECT_TITLE: Retinal Ganglion Cell Dendrite and Synapse Regeneration in Glaucoma: the Role of Insulin Signaling.

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Abbreviations;Achievement;Address;Advisory Committees;anti-cancer research;Appointment;Award;Biometry;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer research center director;cancer therapy;career;Caring;Catchment Area;CCL21 gene;citizen science;Clinic;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;college;Communities;community advisory board;community engagement;Community Outreach;Complex;Confocal Microscopy;data management;Direct Costs;Disease;Diverse Workforce;Education;Effectiveness;Enrollment;Ensure;Evaluation;Faculty Recruitment;Florida;Flow Cytometry;Fostering;Funding;Genetic Research;Goals;Good Manufacturing Process;Growth;Health;Immune response;individualized prevention;Institution;Intervention Trial;investigator-initiated trial;Investments;Last Name;Leadership;Malignant neoplasm of cervix uteri;Malignant Neoplasms;meetings;member;Mission;Monitor;NCI Center for Cancer Research;NCI-Designated Cancer Center;next generation;next generation sequencing;novel;Output;Peer Review;Policies;Policy Making;Population;Population Heterogeneity;Population Research;Population Sciences;prevent;Prevention strategy;process improvement;programs;Publications;Qualifying;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Role;Safety;Science;Scientific Advances and Accomplishments;Scientist;screening program;Site;Strategic Planning;Structure;Text;Training;Training and Education;Training Support;Translating;Translational Research;Translations;treatment response;treatment strategy;treatment trial;tumorigenesis;Universities;Vision;Woman;Workforce Development;working group

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: ATFI, AZEDDINE  (contact)

PROJECT_TERMS: Ablation;Accounting;Activins;Address;Affect;anti-cancer research;Apoptosis;Articulation;Autophagocytosis;Award;Awareness;Basic Science;Biological;biomarker identification;Cancer Biology;Cancer Burden;Cancer Cachexia;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer genome;Cancer Patient;cancer prevention;Catchment Area;Cell Communication;cell growth;Cell Physiology;Cell Survival;Cells;Cellular Metabolic Process;Cellular Stress;Characteristics;Chemotherapy-induced peripheral neuropathy;Collaborations;college;community engagement;Community Outreach;Complex;Dedications;Development;Developmental Therapeutics Program;Diagnostic;DNA biosynthesis;Drug toxicity;Effector Cell;endoplasmic reticulum stress;Ensure;Environment;Epigenetic Process;ethnic minority;Faculty;Female;Funding;Gene Expression;gene network;Genes;Genetic;Goals;Growth;Human;Immune;immunogenicity;Individual;Inflammation;innovation;inter-institutional;Invaded;K-Series Research Career Programs;Lipids;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mentors;Mentorship;Molecular Genetics;molecular marker;Molecular Target;Mus;National Cancer Institute;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Oncoproteins;Outcomes Research;Pathogenesis;Pathway interactions;Patients;Peer Review;permissiveness;Pharmaceutical Preparations;prevent;Prevention;Primary carcinoma of the liver cells;Productivity;Prognosis;programs;Publications;Publishing;racial minority;Regulation;Regulatory T-Lymphocyte;Reporting;Research;Resistance development;resistance mechanism;response;Role;Schools;Science;Scientist;Signal Pathway;Signal Transduction;social health determinants;SPHK1 enzyme;Strategic Planning;Stromal Neoplasm;Students;targeted treatment;Therapeutic;tool;Training;transcriptomics;translational study;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;United States National Institutes of Health;Universities;Virginia;Woman;Work

PROJECT_TITLE: Cancer Biology Research Program


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative  The cornea of the eye has a curved surface that allows it to focus light on the retina, and abnormal corneal curvature causes visual problems such as myopia, hyperopia, astigmatism or keratoconus. We plan to use a simple model system, the fruit fly Drosophila, to investigate how the cells that produce the cornea generate its normal curvature. We will then test whether the same mechanisms are involved in the development of the mouse and human cornea, which would enable us to use this system to gain insights into human visual disorders.

PI_NAMEs: TREISMAN, JESSICA E (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adult;Apical;Area;Astigmatism;Biological Models;Biology;CCAAT-Enhancer-Binding Proteins;Cell secretion;Cells;Characteristics;Cornea;Corneal dystrophy;corneal epithelium;Crystallins;Data;Defect;Development;Disease;Drosophila genus;Ecdysone;Epithelial Cells;Epithelium;experimental study;extracellular;Extracellular Matrix;Eye;fly;Genes;Genetic Models;Genetic Transcription;Homologous Gene;Hormonal;Human;Hyperopia;Insecta;insight;Keratoconus;lens;Lens development;Light;limbal;Mediating;model organism;Modeling;Molecular;mouse development;Mus;mutant;Mutate;Mutation;Myopia;Organ;Organoids;overexpression;Pattern;Peripheral;Phenotype;Photoreceptors;Pigments;PRDM1 gene;Process;Property;protein expression;Protein Secretion;Proteins;Radial;Regulation;Repression;Retina;Retinal Cone;Role;Shapes;Source;stem cells;steroid hormone;Structure;Surface;System;Testing;Tissues;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Up-Regulation;Vision Disorders;Visual

PROJECT_TITLE: Mechanisms of development of curved refractive surfaces

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The primary goals of the proposed Harvard K12 Women’s Reproductive Health Research Career Development Program are to: 1) recruit a diverse group of obstetrician- gynecologist physicians of high motivation and talent for academic medicine, 2) provide them with the best resources, scientific environment, intensive training and mentoring in all aspects of high-impact and socially responsible research conduct; and 3) advise them on grantsmanship and career development and see them through a successful transition to an independent research position. The public health importance is related to meeting the Nation’s biomedical, behavioral and clinical research needs and enhanced by the special attention to biological factors associated with disparities in reproductive health.

PI_NAMEs: NOUR, NAWAL M. (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Advisory Committees;Area;Attention;base;Biological Specimen Banks;Biometry;Boston;career;career development;Career Mobility;Clinical;data management;data repository;Development;Discipline of obstetrics;Education;endometriosis;Environment;Epidemiology;Equipment;ethnic disparity;Exposure to;fertility preservation;General Hospitals;good laboratory practice;Gynecologic;Gynecologist;Gynecology;Health;health disparity;healthy pregnancy;high risk;Hormones;Hospitals;Institution;Israel;Massachusetts;Medical center;medical schools;Medicine;Mentors;Metabolic;microbiome;Minority Groups;Molecular;patient population;Pediatric Hospitals;Physicians;Program Development;programs;Public Health Schools;Qualifying;racial disparity;Recommendation;reproductive outcome;Research;Resources;Scientist;Stress;Structure;Thinking;Time;Toxic Environmental Substances;Training;Underrepresented Minority;Woman;women's reproductive health

PROJECT_TITLE: Transdisciplinary Harvard WRHR Career Development for Gynecologists and Obstetricians


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Unlike mammals, zebrafish exhibit a remarkable ability to regenerate retinal neurons that were lost to injury or disease and therefore, can recover vision when blinded. Key to this regenerative response are Müller glial cells that produce multipotent progenitors for retinal repair. Our research aims to identify the mechanisms distinguishing pro-regenerative Müller glial cells in zebrafish from non-regenerative Müller glia in mammals.

PI_NAMEs: GOLDMAN, DANIEL J (contact)

PROJECT_TERMS: Adopted;Adult;adult stem cell;Biological Assay;Blinded;Blindness;Brain;Cell division;Cell Transplantation;Cells;Characteristics;Development;disability;Disease;Disease Progression;endogenous stem cells;Event;Exhibits;Eye diseases;Fishes;Gene Expression;Gene Expression Profile;Genes;Genetic;Glaucoma;Goals;Grant;Heterogeneity;Individual;injured;Injury;insight;Lateral;Learning;Macular degeneration;Mammals;Morphology;Muller's cell;Multipotent Stem Cells;Mus;Natural regeneration;Nerve Degeneration;Neuroglia;neuron regeneration;Neurons;notch protein;Persons;Play;Population;postnatal;programs;Proliferating;Property;Radial;regeneration potential;regenerative;Regenerative response;repaired;Research;Resistance;response;response to injury;restoration;Retina;Retinal Degeneration;retinal neuron;retinal progenitor cell;retinal regeneration;retinal stimulation;Retinitis Pigmentosa;Role;Scientist;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Specific qualifier value;stem cell population;stem cells;stemness;Structure;System;Testing;transcriptome;transcriptome sequencing;transcriptomics;Vision;Zebrafish

PROJECT_TITLE: Mechanisms underlying Muller glia’s regenerative potential


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: GEORGE, THOMAS J. (contact)

PROJECT_TERMS: Abbreviations;Address;Advanced Malignant Neoplasm;Adverse event;anti-cancer research;Biometry;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer diagnosis;Cancer Intervention;Catchment Area;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Services;clinical trial protocol;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;community engagement;Community Outreach;Computerized Medical Record;COVID-19 impact;Data;data integrity;data management;Disease;Early Therapeutic-Clinical Trials Network;Electronics;Enrollment;Ensure;Florida;Health;Immune response;Individual;Industry;Information Dissemination;Infrastructure;Institution;Intervention;Investigational Therapies;investigator-initiated trial;Last Name;Lead;Leadership;life span;Malignant Neoplasms;member;Methodological Studies;Minority;Monitor;NCI Center for Cancer Research;novel therapeutics;Oncology;pandemic disease;Participant;participant enrollment;participant safety;patient screening;Patients;Pediatric Oncology Group;Peer Review;Pharmaceutical Services;Pharmacy facility;Phase;Population;Population Sciences;pre-clinical;Principal Investigator;Procedures;programs;protocol development;Protocols documentation;quality assurance;Quality Control;Recovery;recruit;Refractory Disease;Regulatory Affairs;Reporting;Research;Research Activity;Research Design;Research Personnel;research study;Resource Sharing;Resources;Safety;Science;screening;Site;sound;Specific qualifier value;Strategic Planning;Structure;success;Supportive care;System;Text;Training Activity;Training and Education;Translations;treatment response;treatment trial;Underrepresented Minority;Underserved Population;Universities;University adminstration;Voting;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The Western Region Universities Consortium (WRUC) provides training to protect workers and communities from exposure to hazardous materials/waste, including chemical, biological and radiological materials; and to prevent, prepare for and respond to emergencies. Programs are implemented through a cooperative agreement with the National Institute of Environmental Health Sciences and support the goals of U.S. government agencies such as the EPA, OSHA, DOT, NIOSH, DHS, and FEMA. WRUC partners with state and local agencies, tribal entities, and communities in West Coast states, Alaska, the Southwest and along the U.S.-Mexico border to promote public health and environmental sustainability in the region.

PI_NAMEs: RILEY, KEVIN WILLIAM (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Aerosols;Alaska;Arizona;Biological;California;career;career preparation;Chemicals;Climate;Collaborations;Communities;Disasters;Disease;Earthquakes;Educational Curriculum;Educational workshop;Emergency response;emergency service responder;Emergency Situation;Engineering;environmental justice;Exposure to;Geography;Goals;Government Agencies;hazard;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;Health Personnel;Healthcare;Hour;Industry;Labor Unions;Language;Life;literacy;Los Angeles;Low Income Population;manufacturing facility;member;Mexico;Modeling;National Institute of Environmental Health Sciences;Occupational Health;occupational health/safety;Occupations;operation;outreach;Pacific Northwest;Pathway interactions;people of color;Policies;prevent;Prevention;Process;Program Development;programs;promote resilience;Public Health;Radiology Specialty;Readiness;Recovery;Resources;response;Safety;Safety Management;School Nursing;Schools;skills;Trainers Training;Training;Training Activity;Training Programs;Tribal group;tribal organization;U-Series Cooperative Agreements;Underserved Population;Unemployment;Universities;Washington;wasting;Wildfire;Workforce Development;Youth

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training (U45)


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention

PI_NAMEs: FABER, ANTHONY CHARLES (contact)

PROJECT_TERMS: Address;Adult;African American Women;Antineoplastic Agents;Area;Automobile Driving;Basic Science;Biological Products;biomarker identification;Black race;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cancer Survivorship;cancer therapy;Catchment Area;Clinic;Clinical Cancer Center;Clinical Investigator;Clinical Trials;Clinical Trials Network;Collaborations;college;Combined Modality Therapy;community center;Community Clinical Oncology Program;Country;Critiques;Dedications;design;Development;Developmental Therapeutics Program;Diagnosis;Disease;Disparity;disparity gap;Doctor of Philosophy;Drug Combinations;drug development;drug discovery;early phase trial;Endometrial Carcinoma;Enrollment;Ethnic Origin;Evaluation;Foundations;Funding;Goals;Hematologic Neoplasms;Immune Targeting;Immunologist;Immunotherapy;improved;Industry;Infrastructure;Institution;Intervention;Investigational Therapies;Investments;Journals;Laboratories;Lead;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;member;Minority;Minority Enrollment;Minority Recruitment;Monitor;Monitoring Clinical Trials;National Cancer Institute;National Clinical Trials Network;Nature;new therapeutic target;novel;novel therapeutics;Patients;pediatric patients;Peer Review;Pharmaceutical Preparations;Pharmacodynamics;Phase;pre-clinical;precision medicine;programs;Protocols documentation;Publications;Publishing;Race;rational design;Recurrence;Regimen;Reporting;Research;Research Personnel;Research Priority;response;rural patients;Schools;Science;Scientist;Signal Pathway;small molecule;Strategic Planning;System;Therapeutic;Therapeutic Research;therapeutically effective;therapy development;therapy resistant;Translating;translational clinical trial;Translational Research;Translations;treatment disparity;treatment trial;tumor;Underrepresented Minority;United States National Institutes of Health;Universities;Validation;Virginia;Work;working group

PROJECT_TITLE: Developmental Therapeutics Research Program


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Exposure to a new type of flame retardant chemicals is increasing in the United States despite concerns that these chemicals may change hormone levels and brain function in humans. We will observe how children exposed to various levels of flame retardant chemicals may have different thyroid hormone levels, intelligence, and ADHD behaviors. We will also investigate how being exposed to mixtures of chemicals like old flame retardants, new flame retardants, and lead may have different effects on human health outcomes than exposure to single chemicals alone.

PI_NAMEs: PERCY, ZANA  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 12 year old;3 year old;8 year old;Accidents;Adult;Affect;Age;analytical method;Animal Experiments;Animals;Area;Attention deficit hyperactivity disorder;Behavior;Behavior assessment;Behavior Disorders;Biological;Birth;Blood;blood lead;Brain;Chemical Exposure;Chemicals;Child;Childhood;Cognition;cohort;Communities;consumer product;Data;Development;developmental neurotoxicity;Dissociation;Dose;Dust;early childhood;early life exposure;Electronics;Endocrine;Endocrine Disruptors;Environment;Environmental Health;Equation;Esters;exposed human population;Exposure to;Flame Retardants;follow-up;Furniture;Goals;Government;Hand;Health;Health education;Health Policy;Home;hormone regulation;Hormones;House Dust;Human;in vivo;Ingestion;insight;Intelligence;Joints;Knowledge;Lead;Lead levels;Link;Longitudinal cohort;Marketing;Measurement;Measures;Mediation;Modeling;neurobehavior;neurobehavioral;neurotoxic;neurotoxicity;Oral cavity;Organophosphates;Outcome;Pathway interactions;Pattern;Phase;polybrominated diphenyl ether;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Production;Property;prospective;Public Health;Research;response;Route;Sampling;Series;Serum;Source;Statistical Methods;Symptoms;System;Testing;Textiles;thyroid disruption;Thyroid Function Tests;Thyroid Hormones;Thyrotropin;Thyroxine;Time;Toxic effect;Toxic Environmental Substances;Toxicology;Triiodothyronine;Umbilical Cord Blood;United States;Urine;Woman;Work

PROJECT_TITLE: Assessing early-life exposure to replacement flame retardant chemicals and associations with thyroid disruption and altered neurobehavioral function in a longitudinal birth cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-G(20)]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: THOMAS, RYAN M. (contact)

PROJECT_TERMS: Abbreviations;Achievement;Amendment;anti-cancer research;Appropriateness Review;authority;biobehavior;Biometry;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Catchment Area;citizen science;Classification;Clinical;Clinical Cancer Center;clinical care;Clinical Data;clinical investigation;clinical practice;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Clinical Trials Network;clinically relevant;Committee Members;Committee Membership;community engagement;Community Outreach;COVID-19 pandemic;Data;data integrity;data management;Devices;Discipline of Nursing;Disease;Documentation;Early Therapeutic-Clinical Trials Network;Enrollment;Ensure;expectation;Faculty;Florida;Future;Goals;Health;Health Services Research;Immune response;Institution;Institutional Review Boards;interdisciplinary approach;interest;Intervention;Intervention Studies;Intervention Trial;Investigational Drugs;Investigational Therapies;investigator-initiated trial;Laboratories;Last Name;Malignant Neoplasms;member;Methodology;Mission;Monitor;multidisciplinary;National Clinical Trials Network;Participant;participant safety;Peer Review;Pharmacy facility;Population Sciences;Principal Investigator;Procedures;Process;programs;protocol violation;Protocols documentation;Qualifying;recruit;Research;Research Design;research study;Resources;Review Committee;Risk;Safety;Science;Scientific Evaluation;Site;sound;Statistical Data Interpretation;Strategic vision;Structure;System;Text;timeline;treatment response;tumorigenesis;Universities

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: FINDLAY, VICTORIA JANE (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African American;African American population;anti-cancer research;associated symptom;Automobile Driving;Award;Behavior;Behavioral;Biological;Black Populations;Black race;Breast;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Control Research Program;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer risk;cancer type;Caregivers;Catchment Area;Charge;Clinic;Clinical;Collaborations;college;Communities;community center;Community Clinical Oncology Program;community engaged approach;community engaged research;community engagement;Community Health;community intervention;Community Outreach;Continuity of Patient Care;Death Rate;Diagnosis;Discipline;Disease;Disparity;disparity reduction;Doctor of Philosophy;Early Diagnosis;early screening;effectiveness testing;Enrollment;Ensure;Equity;Ethnic Origin;Fostering;Funding;Funding Opportunities;gastrointestinal;geographic disparity;Goals;health equity;Health Promotion;Historically Black Colleges and Universities;Hot Spot;Humanities;improved;Individual;Inequity;inter-institutional;International;intersectionality;Intervention;intervention participants;Intervention Studies;Intervention Trial;Investments;Lead;Leadership;Life Style;Long-Term Survivors;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;Medical;medical schools;meetings;member;Methods;mid-career faculty;Minority;Minority Groups;Mission;multidisciplinary;multimodality;National Cancer Institute;National Institute of Drug Abuse;Nature;obesity prevention;Operative Surgical Procedures;Outcome;Patients;Peer Review;Pharmacy facility;Policies;population health;Population Heterogeneity;Prevalence;Prevention;Preventive;Principal Investigator;professor;programs;Prostate;Psychiatry;Publications;Quality of life;Race;racial disparity;Records;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Risk Factors;risk mitigation;Rural;Science;Scientist;screening disparities;social;South Carolina;Specialized Program of Research Excellence;Strategic Planning;Supportive care;survivorship;symposium;Symptom Burden;Testing;Tobacco;tobacco control;tobacco products;Training Programs;translational engagement;United States National Institutes of Health;Universities;Urban Community;Virginia

PROJECT_TITLE: Cancer Prevention and Control Research Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Program Director/Principal Investigator (Last, First, Middle): Strakowski, Stephen M. NARRATIVE Bipolar I disorder typically emerges during adolescence or young adulthood. Using longitudinal study of ventral brain network in youth with or without a familial risk for bipolar I disorder, and with or without childhood maltreatment, we propose to define how brain developmental abnormalities evolve to produce bipolar I disorder. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

PI_NAMEs: ALMEIDA, JORGE R C;STRAKOWSKI, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 21 year old;Adolescence;Adult;Affective;Amygdaloid structure;Anxiety;Anxiety Disorders;Attention deficit hyperactivity disorder;Behavior;Behavioral;Bipolar Disorder;Bipolar I;Brain;Brain region;Characteristics;Child Abuse and Neglect;Clinical;Cognitive;Computer Models;Corpus striatum structure;Data;Development;Diffusion Magnetic Resonance Imaging;Disease;early life adversity;early life stress;Early-life trauma;emotion dysregulation;emotion regulation;Emotional;Event;experience;Exposure to;Failure;Family;Family history of;Feedback;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;General Population;Globus Pallidus;Goals;Heritability;Hypersensitivity;Image;Impairment;Individual;Inherited;Lead;Link;Longitudinal Studies;Machine Learning;Manic;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mind;mood symptom;Moods;Motivation;neural;Onset of illness;Outcome;Pathway interactions;Persons;Phenotype;Prefrontal Cortex;prevent;Principal Investigator;programs;psychosocial;Recording of previous events;recruit;Recurrence;Reporting;response;reward processing;Rewards;Risk;Risk Factors;Site;Subgroup;substance misuse;Substance Use Disorder;suicidal behavior;Suicide;Symptoms;Syndrome;System;Testing;Thalamic structure;Time;Unipolar Depression;young adult;Youth

PROJECT_TITLE: 1/2 Neurodevelopmental and clinical trajectories of youth at risk for bipolar I disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEE, JI-HYUN  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Artificial Intelligence;Bioinformatics;Biological Assay;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer health equity;Cancer Research Project;cancer therapy;Clinical Cancer Center;Clinical Research;clinical trial analysis;clinical trial protocol;Clinical Trials;Clinical Trials Design;Collaborations;Complex;Computational Biology;computerized data processing;cost effective;Data;Data Analyses;Data Collection;data imputation;data integrity;data sharing;deep learning;design;Development;Diagnostic;Disease;Ensure;Environment;Epitopes;Evaluation;experience;Experimental Designs;experimental study;Faculty;Florida;Funding;Future;Genomics;Grant;Guidelines;Health;health disparity;High Performance Computing;high throughput analysis;Human Resources;In Vitro;in vivo;indexing;Individual;innovation;Institution;Intervention;Investments;Machine Learning;Malignant Neoplasms;Manuscripts;Mediation;member;Methodology;microbiome;microbiome analysis;model development;Modeling;Monitor;multiple data sources;NCI Center for Cancer Research;NCI-Designated Cancer Center;next generation sequencing;novel;Observational Study;patient safety;Peer Review;peer support;predictive modeling;Preparation;Prevention;Procedures;prognostic model;programs;Protocols documentation;Publications;Qualifying;Randomized;randomized trial;Reproducibility;Research;research and development;Research Design;Research Personnel;research study;Research Support;Resource Sharing;Resources;Safety;Sample Size;Science;Scientist;Services;single-cell RNA sequencing;Site;Software Engineering;Statistical Data Interpretation;Statistical Methods;statistics;Strategic Planning;Stratification;System;transcriptome;Triage;trial design;United States National Institutes of Health;Universities;Visualization;web portal;Work

PROJECT_TITLE: Biostatistics and Quantitative Sciences Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Retinal images captured with adaptive optics scanning ophthalmoscopes are severely distorted due to constant involuntary eye movement. In this project, we propose to develop low-cost high-speed instrumentation and software to compensate for this movement to improve the understanding, diagnosing, and management of eye diseases.

PI_NAMEs: DUBRA, ALFREDO  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: adaptive optics;adaptive optics scanning laser ophthalmoscopy;Address;Algorithms;Bypass;cellular imaging;Clinical;Communities;Compensation;Computer software;cost;Crystalline Lens;Data;Dedications;Diagnosis;Disease;Disease Progression;Early Diagnosis;Electronics;Eye;Eye diseases;Eye Movements;Failure;Friction;Functional Imaging;Glaucoma;Goals;Human;human imaging;human subject;Image;image registration;imaging modality;improved;Individual;Inner Nuclear Layer;instrument;instrumentation;Light;Location;Measurement;Measures;Mechanics;meter;Microscopic;millisecond;Mission;Modeling;Motion;Movement;Ocular Motility Disorders;Ophthalmoscopes;Ophthalmoscopy;optic nerve disorder;Optics;Pathologic Nystagmus;Pathology;Play;prediction algorithm;Psychophysics;Pupil;Research;Residual state;Resolution;Retina;retinal imaging;Rotation;Sampling;Scanning;software development;Speed;Stimulus;structural imaging;Structure;System;Technology;Testing;Time;Visualization

PROJECT_TITLE: Low Latency Eye-Motion Compensation


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative A vaccine to prevent HIV-1 infection is only likely to be effective if it includes components that are able to stimulate the human immune system into producing antibodies (designated bNAbs) that can neutralize the infectivity of multiple strains of the HIV-1 virus. To stimulate the production of bNAbs, we make proteins known as SOSIP trimers that are based on the only part of the virus that is targeted by bNAbs, the envelope glycoprotein (Env) on the viral surface. In this project, we propose to continue to make and study new and better versions of the SOSIP trimer, for our own research, to provide to collaborators and to donate to other scientists who now use SOSIP trimer designs for their own vaccine-development or related research programs.

PI_NAMEs: MOORE, JOHN P (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Academic Medical Centers;Amino Acid Substitution;Animals;Antibodies;Antibody Response;Antigens;Autologous;Binding;biophysical analysis;biophysical techniques;Biophysics;Cells;Clinical Trials;Collaborations;Communication;Complex;Cryoelectron Microscopy;Data;design;design verification;Development;Doctor of Philosophy;Electron Microscopy;Epitopes;flexibility;Foundations;Funding;Generations;Genotype;Germ Lines;Glycoproteins;Goals;Good Manufacturing Process;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;Hydrogen;Immune system;immunogenicity;improved;Infection;insight;iron oxide nanoparticle;Letters;Macaca;Mass Spectrum Analysis;Mediating;medical schools;milligram;Negative Staining;neutralizing antibody;Oryctolagus cuniculus;Outcome;prevent;Principal Investigator;Procedures;Process;Production;programs;Property;prophylactic;Proteins;prototype;Reagent;Recombinant Proteins;Recombinants;Regulation;Research;Research Institute;Research Project Grants;Resolution;Respiratory Syncytial Virus Vaccines;response;Roentgen Rays;Scientist;Shapes;stable cell line;Structure;Surface;Testing;trimer core;Uncertainty;United States National Institutes of Health;vaccine development;Vaccine Research;vaccine trial;Vaccines;Viral;Virion;Virus;ward;Work;X-Ray Crystallography

PROJECT_TITLE: Cleaved, stabilized HIV-1 Env trimers for structural and vaccine studies


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SHEPPARD, VANESSA B (contact)

PROJECT_TERMS: Address;Adopted;Area;Articulation;Awareness;Basic Science;Behavior Therapy;Bioethics;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;Cancer health equity;cancer prevention;cancer research center director;cancer risk;care delivery;Caring;Catchment Area;Cervical Cancer Screening;Cities;Clinical Cancer Center;clinical care;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community building;community center;Community Clinical Oncology Program;community engaged research;community engagement;Community Health;Community Outreach;community partners;County;COVID-19 pandemic;Data;data access;Decision Making;digital media;Disparity;Doctor of Philosophy;Early Diagnosis;Education;Elderly;Environment;ethnic minority;Ethnic Origin;Evaluation;evidence base;Faculty;Faith;Faith leader;Family;Federally Qualified Health Center;Feedback;Foundations;Funding;Future;Geography;Health;Health Educators;health inequalities;Health Policy;Health system;Healthcare;Historically Black Colleges and Universities;Home;Human Papilloma Virus Vaccination;improved;Individual;Institution;interest;Investments;Leadership;Lesbian Gay Bisexual Transgender Queer;Logic;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;medically underserved;Medicine;member;Minority;minority communities;Minority-Based Community Clinical Oncology Program;Modeling;Monitor;multimodality;National Cancer Institute;Obesity;operation;Outcome;Persons;Play;Policies;Population Heterogeneity;Population Sciences;Prevention;prevention practice;Process;programs;Public Policy;Race;racial minority;Radio;Reporting;Research;Research Activity;Research Personnel;Resources;response;Role;Rural Community;rural setting;safety net;screening;Screening for cancer;Services;Shapes;Smoke;Social Distance;socioeconomics;Statistical Data Interpretation;Strategic Planning;Survivors;survivorship;Systems Analysis;Teleconferences;tobacco control;Training;Translational Research;Trust;trustworthiness;Underserved Population;United States Health Resources and Services Administration;Universities;urban setting;Vaccination;Virginia;virtual;virtual technology

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: KELLISH, PATRICK  (contact)

PROJECT_TERMS: Abbreviations;Accounting;Adherence;anti-cancer research;Antibodies;Applications Grants;Back;Biological Markers;Biometry;Biotechnology;Brain;Cancer Center;Cancer Center Support Grant;Cancer Control;Cell Separation;Cells;Cellular Morphology;Certification;Charge;Clinical;Collaborations;Communities;Complex;Confocal Microscopy;Consultations;cost;cost effective;COVID-19 pandemic;Data;Data Analyses;design;Development;Doctor of Philosophy;Educational workshop;Effectiveness;Ensure;Equipment;exosome;experience;Experimental Designs;Feedback;first-in-human;Florida;Flow Cytometry;fluorescence microscope;Funding;Future;Genetic Research;Growth;Health;Hour;Image;Immune;Immune response;Immunobiology;Immunologist;Immunophenotyping;Immunotherapy;improved;Infrastructure;Institution;instrument;instrumentation;Knowledge;Laboratories;Lasers;Last Name;Letters;live cell imaging;Malignant Neoplasms;member;Methods;Microscopy;Mission;Modernization;multi-photon;NCI Center for Cancer Research;operation;particle;Peer Review;Phenotype;Policies;Population Sciences;Postdoctoral Fellow;Procedures;Productivity;programs;Publications;Recommendation;recruit;Reproducibility;Research;Research Activity;Research Project Grants;Research Support;Reservations;Resource Sharing;Resources;response;RNA vaccine;Sampling;satisfaction;Scanning;Science;Services;single cell analysis;Solid Neoplasm;Sorting;Strategic Planning;student training;Students;Surface;Surface Antigens;Surveys;System;Technology;time use;Tissues;Training;treatment response;tumorigenesis;ultra high resolution;United States National Institutes of Health;Universities;Vaccine Clinical Trial;Vendor

PROJECT_TITLE: Flow Cytometry and Confocal Microscopy Shared Resource


PI_NAMEs: MADORE, STEVEN JAMES (contact)

PROJECT_TERMS: Abbreviations;Address;Adherence;Adopted;Advanced Malignant Neoplasm;anti-cancer research;Applications Grants;ATAC-seq;Automation;base;Bioinformatics;Biometry;Biotechnology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;Cell Survival;Cells;ChIP-seq;Chromatin Structure;Chromium;Cleavage Under Targets and Release Using Nuclease;Clinical;cluster computing;Collaborations;Collection;college;Communities;Complex;Computer Analysis;Confocal Microscopy;Consultations;cost;cost effective;Cost Savings;COVID-19 pandemic;Culicidae;Data;Data Analyses;Data Set;DNA;DNA Library;DNA Methylation;DNA sequencing;Educational workshop;Effectiveness;Ensure;Epigenetic Process;epigenomics;Equipment;experience;Experimental Designs;Feedback;Florida;Flow Cytometry;Funding;Gene Expression Regulation;Genetic Research;genetic variant;genome sequencing;Genomics;Health;High Performance Computing;Immune response;Immunobiology;improved;Infrastructure;Institution;instrument;instrumentation;Investments;Laboratories;Last Name;Learning;Letters;Libraries;Liquid substance;Malignant Neoplasms;meetings;member;Messenger RNA;metagenome;microbiome;MicroRNAs;Miniaturization;Mission;Molecular Epidemiology;Multiomic Data;nanolitre;nanopore;NCI Center for Cancer Research;new technology;next generation sequencing;operation;Peer Review;Population Sciences;Preparation;Procedures;programs;Proteins;Publications;Quality Control;Reaction;Recommendation;recruit;Reproducibility;Research;Research Project Grants;research study;Research Support;Resource Sharing;Resources;response;Ribonucleases;Ribosomal RNA;RNA;RNA Splicing;Robot;Robotics;Running;Sampling;Schedule;Science;sequencing platform;Services;single cell ATAC-seq;single-cell RNA sequencing;Small RNA;Strategic Planning;Supervision;Surveys;System;Technology;Training;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor microenvironment;tumorigenesis;United States National Institutes of Health;Universities;Untranslated RNA;Variant;Vendor;whole genome;Work

PROJECT_TITLE: Next Generation Sequencing Shared Resource


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The UW Women's Reproductive Health Research (WRHR) Program plans to promote diversity in the approach, and originality in the execution of our career development program. The novel multidisciplinary methods proposed to train early career obstetrician gynecologist scientists are most apt to be successful in answering questions of greatest merit, with maximum possibility of impacting the health of all women.

PI_NAMEs: GOFF, BARBARA ANN (contact)

PROJECT_TERMS: career;career development;clinical training;Communicable Diseases;design;Development;Discipline;Discipline of obstetrics;disorder prevention;Education;Environment;experience;Family;Fostering;Genetic;Genomics;global health;Goals;Gynecologist;Gynecology;Health;health care disparity;improved;Individual;Institution;interest;Investigation;medical schools;medical specialties;Medicine;Mentors;Molecular Biology;multidisciplinary;Personal Satisfaction;Physicians;Positioning Attribute;premature;Program Development;programs;recruit;Reproductive Immunology;Research;Research Personnel;Research Training;Scientist;Time;Training;Universities;Washington;Woman;Women's Health;women's reproductive health

PROJECT_TITLE: Women's Reproductive Health Research at the University of Washington


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: WINN, ROBERT A. (contact)

PROJECT_TERMS: Area;Articulation;Award;Basic Science;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical Sciences;Communities;Development;Extramural Activities;Faculty;Faculty Recruitment;Funding;Goals;Incidence;innovation;Institution;Investments;Malignant Neoplasms;mortality;NCI Center for Cancer Research;outcome disparities;Philanthropic Fund;Population Sciences;Process;programs;recruit;Research;Research Personnel;Research Project Grants;Scientist;Strategic Planning;Translational Research;Universities;Virginia

PROJECT_TITLE: Developmental Funds (Dev. Funds)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: The blood system has been typically studied using techniques that disrupt the bone marrow tissue. Our application will develop new tools that can directly visualize and study live cells directly in the bone marrow. This new approach will generate a spatial map of where exactly early blood production takes place in the normal, disease and aged conditions.

PI_NAMEs: CAMARGO, FERNANDO  (contact);LIN, CHARLES P.

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: aged;Aging;Anatomy;Architecture;Behavior;Biological;Biological Assay;Blood;blood formation;Bone Marrow;Bone Marrow Cells;Catalogs;Cell Transplantation;Cells;clinically relevant;Clone Cells;Collection;daughter cell;Development;Developmental Cell Biology;Disease;Event;Flow Cytometry;Fluorescent in Situ Hybridization;Generations;Goals;Growth;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell niche;Hematopoietic stem cells;Hematopoietic System;Image;image guided;imaging scientist;In Situ;Individual;Inflammation;insight;interdisciplinary approach;Knowledge;Label;Lasers;Location;Maps;Marrow;Measurement;Mediating;Microscope;Microscopy;Molecular;mouse model;multiple omics;Mus;neglect;novel;novel strategies;Optics;Outcome;Process;Production;progenitor;Reagent;Recommendation;Reporter;Resolution;Resources;Role;Seminal;single molecule;Sister;stem cell biology;stem cells;success;System;Techniques;Technology;Text;Textbooks;Time;Tissues;tool;Transcriptional Regulation;transcriptome;transcriptomics;two-photon;Visualization;Visualization software;Work

PROJECT_TITLE: Generation of  a temporal, spatial, and molecular map of in situ hematopoiesis


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Infertility;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Uterine Cancer;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Proper endometrial repair after menstruation is necessary to allow for subsequent menstrual cycles and pregnancy. The uterus is prone to diseases including endometrial cancer and endometriosis that may result from improper regulation of endometrial repair. This work will provide important information about normal endometrial repair mechanisms so as to better understand how mis-regulation may contribute to uterine diseases and infertility in women.

PI_NAMEs: PATTERSON, AMANDA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Adult;Asherman Syndrome;Bone Marrow;Bone Marrow Cells;Cell Physiology;cell type;Cells;Characteristics;Development;Disease;Embryo;Embryonic Development;Endometrial;Endometrial Carcinoma;Endometrial Stromal Cell;endometriosis;Endometrium;Epithelial Cells;epithelial repair;epithelial stem cell;epithelial to mesenchymal transition;Epithelium;epithelium regeneration;Experimental Designs;experimental study;Female infertility;Fertility;Functional disorder;Goals;Hormone Responsive;Human;In Vitro;in vivo;Infertility;innovation;insight;Investigation;Knowledge;Label;Laboratories;Malignant Neoplasms;Menstrual cycle;Menstruation;Mesenchymal;Modeling;mouse model;Mus;natural Blastocyst Implantation;Natural regeneration;novel;Organ;Pathway interactions;Physiological;Postpartum Period;Pregnancy;Preparation;Process;re-epithelialization;Regulation;repaired;Reporter;Reporting;reproductive;Research;Role;single-cell RNA sequencing;stem cells;Stromal Cells;Structure of paramesonephric duct;Techniques;Testing;theories;Therapeutic;Thinness;tissue regeneration;Tissues;transcriptome;transdifferentiation;transplant model;Transplantation;Uterine Diseases;Uterus;Woman;Work

PROJECT_TITLE: Functional characterization of mesenchymal-epithelial transition (MET)-derived cells in normal endometrial regeneration

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: FAWCETT, PAUL M (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Applications Grants;Area;authority;Basic Science;Bioinformatics;Biostatistics Shared Resource;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer research center director;Capital;Charge;Clinical Research;Clinical Sciences;Communication;Communities;Computers and Advanced Instrumentation;Consult;Consultations;cost;cost effective;cost estimate;data acquisition;Data Analyses;Decision Making;digital;Doctor of Philosophy;Educational workshop;Ensure;equipment acquisition;Evaluation;Faculty;Feedback;Flow Cytometry Shared Resource;Fostering;Funding;Goals;Growth;Guidelines;health communication;Health Disparities Research;health equity;Individual;Informatics;Infrastructure;innovation;insight;Institution;instrument;instrumentation;Investments;Knockout Mice;Knowledge;Laboratory Research;Laws;Leadership;lipidomics;Malignant Neoplasms;Mass Spectrum Analysis;meetings;member;metabolomics;Methods;Microscopy;Modeling;Modernization;Monitor;mouse model;Names;NCI Center for Cancer Research;Office Management;operation;outreach;Periodicals;Population Sciences;Positioning Attribute;Process;programs;Proteomics;Qualifying;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Resource Development;Resource Sharing;Resources;Role;Science;Secure;Services;Strategic Planning;Structure;Surveys;Technology;tissue resource;Training;Training and Education;Transgenic Organisms;Translational Research;Universities;Update;Vendor;Virginia;Work

PROJECT_TITLE: Shared Resource Management (SRM)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Hypertension costs the U.S. about $131 billion annually. This research on technology-based care models to improve hypertension care in persons with early stage Alzheimer’s disease and Alzheimer’s Disease Related Dementia will prevent stroke and cardiovascular disease, reduce caregiver burden, and improve health equity.

PI_NAMEs: LAKSHMINARAYAN, KAMAKSHI  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Address;Adult;Age;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Atherosclerosis Risk in Communities;Behavioral;Biometry;Blood Pressure Monitors;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular risk factor;career;Caregiver Burden;Caregivers;Caring;Cellular Phone;Chronic Disease;Clinical Pharmacists;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;Community Health;Community Health Systems;cost;Data;Dementia;dementia risk;design;Disease Management;disorder risk;disparity reduction;Economics;Environment;Epidemiology;evidence base;Evidence based intervention;Faculty;Family Caregiver;Focus Groups;Funding;Goals;graduate student;Grant;Guidelines;Health;health care disparity;health equity;health management;Health Policy;Health Resources;Health Services;Health system;Health Technology;Healthcare;Home;Hypertension;hypertension control;hypertension treatment;Impaired cognition;implementation science;improved;innovation;Institution;Intervention;investigator training;K-Series Research Career Programs;Leadership;Low income;Measures;Mediating;Medical;Medical Care Team;medical schools;Medication Management;member;Mentors;mHealth;middle age;mild cognitive impairment;Minnesota;Modeling;Monitor;Neurocognitive;Neurology;Nursing Faculty;older adult;Older Population;Outcome;overtreatment;Participant;Patient Education;Patients;Persons;Pharmaceutical Preparations;pilot trial;Population;Prevention;primary care patient;primary care provider;primary outcome;Principal Investigator;Provider;Public Health Schools;Recommendation;Recovery;Reporting;Research;Research Personnel;Research Support;Resources;Risk Factors;Role;satisfaction;Scientific Advances and Accomplishments;Self Care;side effect;Site;skills;social;Stroke;stroke cognitive outcome;Stroke prevention;stroke risk;stroke survivor;Technology;technology intervention;Testing;Time;Training Programs;transmission process;treatment as usual;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: mGlide-Care: A mHealth Partnership with Care Givers to Improve HTN Management in Patients with Cognitive Impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Cardiac fibrosis, or the accumulation collagen, occurs almost universally in all cardiac diseases and can contribute to the worsening of heart failure. There are no therapies for cardiac fibrosis. In this proposal, we will determine the role of SLIT3-ROBO1 signaling in cardiac collagen regulation as well as in the pathogenesis of cardiac fibrosis. Results of this study will increase our understanding of how cardiac fibrosis occurs and may identify novel targets for antifibrotic therapies.

PI_NAMEs: SI, MING-SING  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acute;Adult;Affect;amphiphysin;antifibrotic treatment;aorta constriction;Binding;Blood capillaries;Cardiac;Cells;Chronic;Clinical;Collagen;congenital heart abnormality;coronary fibrosis;Cytoplasm;Data;Defect;Deposition;Development;Diabetes Mellitus;EFRAC;Event;Extracellular Matrix;Eye;Fibroblasts;Fibrosis;Functional disorder;Glycoproteins;Goals;Hand;Heart Diseases;Heart failure;heart function;Heart Transplantation;Homeostasis;improved;In Vitro;in vivo;inducible Cre;Injury;insight;interstitial;Ischemia;Knock-out;knockout animal;Knockout Mice;Left ventricular structure;Link;LoxP-flanked allele;MADH3 gene;Mediating;Molecular;mouse model;multidisciplinary;Mus;Myocardial;Myocardial Infarction;novel;novel therapeutic intervention;Obesity;Pathogenesis;Pathologic;Pathology;Patients;Pericytes;Perivascular Fibrosis;Phosphorylation;Physiologic intraventricular pressure;Population;postnatal;preservation;pressure;prevent;Production;programs;promoter;Proteins;Publishing;receptor;Regulation;Reporting;Research;response;Role;Rupture;Signal Transduction;Smooth Muscle Myocytes;SRGAP2 gene;Stress;Testing;Transgenic Organisms;unpublished works;Vascular Smooth Muscle;Ventricular Remodeling;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of Cardiac Collagen Content by SLIT3

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]