NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Obesity

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative  Adeno-associated viral (AAV) vectors are mainstream delivery platforms in gene therapy, yet AAV- mediated gene transfer to adipose tissue is left far behind due to the low transduction efficiency and tropism of natural AAV serotypes. Our preliminary studies have found a newly engineered capsid LC.V7 to possess exclusive adipose-tropism while eliminating transduction of liver and other peripheral tissues. This project aims to develop the next generation of AAV vector platform for adipose gene delivery based on the novel LC.V7 capsid, which will provide a powerful tool for basic research and therapeutic purposes.

PI_NAMEs: CAO, LEI  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: adeno-associated viral vector;Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;aged;Albumins;Amino Acid Sequence;Basic Science;Biodistribution;Brain;BSCL2 gene;C57BL/6 Mouse;Capsid;Clinical Trials;Complementary DNA;Coupled;CRISPR/Cas technology;Data;design;Disease;DNA cassette;DNA Shuffling;Dose;Drug or chemical Tissue Distribution;efficacy evaluation;efficacy testing;Engineering;Enhancers;Exclusion;experimental study;Eye;Fatty acid glycerol esters;Flow Cytometry;Gene Delivery;Gene Expression;gene therapy;Gene Transfer;Genetic Complementation Test;genetic manipulation;genome editing;Green Fluorescent Proteins;Heart;Hepatotoxicity;Human;Human Cloning;Hybrids;Immune;improved;in vivo evaluation;Intestines;intraperitoneal;Intraperitoneal Injections;Intravenous;Kidney;Left;Leptin;Lipodystrophy;Liver;Luciferases;Lung;Mainstreaming;Mediating;Messenger RNA;Metabolic;Metabolic syndrome;MicroRNAs;Modeling;Mus;Muscle;Mutation;Names;next generation;nonhuman primate;novel;Obese Mice;Obesity;Oral Administration;Pancreas;Peripheral;Plasmids;Point Mutation;Population;promoter;Proteins;Recommendation;Reporter Genes;Research;Risk;Route;Safety;Serotyping;Skeletal Muscle;small hairpin RNA;Spleen;stem cells;Stomach;Technology;Text;Therapeutic;Thinness;Thymus Gland;Tissues;tool;Toxic effect;Transcript;transduction efficiency;transgene expression;Transgenes;Tropism;Variant;vector;Viral;viral DNA;Viral Genome;viral genomics;Viral Vector;Visceral fat

PROJECT_TITLE: Next generation of AAV vector targeting adipose tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative – Symposium on the Immune System of Bacteria Defining at the mechanistic level how cells resist viral infection is essential to controlling and treating infectious diseases. The proposed 2024 Symposium on the Immune System of Bacteria will convene US and international scientists in the emerging field of bacterial anti-phage defense and the evolutionary connection between the immune system of bacteria and human antiviral immunity. The conference will establish priority directions for future research and create a unique opportunity to foster inclusivity and the next generation of researchers studying microbiology, virology, and immunology.

PI_NAMEs: KRANZUSCH, PHILIP J (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Address;Advertisements;Advocate;Animals;antiviral immunity;Area;Bacteria;Bacteriophages;Biology;Boston;career;Cells;Communicable Diseases;Communities;community building;Conflict (Psychology);Data;Dedications;Disabled Persons;doctoral student;Effectiveness;Ensure;Environment;Evolution;Explosion;Family;Fostering;fundamental research;Generations;Goals;Human;Immune response;Immune signaling;Immune system;Immunity;Immunology;Infection;International;Island;meetings;member;Mentors;Microbe;Microbiology;Mission;Modernization;National Institute of Allergy and Infectious Disease;Natural Immunity;next generation;outreach;pathogen;posters;Principal Investigator;programs;rehearsal;Research;Research Personnel;Research Priority;Science;Scientist;Senior Scientist;Series;Signaling Protein;Surveys;symposium;System;Time;Training;Travel;Viral;virology;Virus;Virus Diseases;virus host interaction;Woman;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: 22q11.2 deletion (22qDel) is a high-risk schizophrenia-associated microdeletion. Several nuclear-encoded mitochondrial proteins are located within the 22q11.2 locus prompting the hypothesis that neuronal mitochondria may be particularly vulnerable to heterozygosity of 22q11.2 genes. This project will determine the impact of the 22q11.2 deletion on mitochondrial biology and neuronal development and may provide novel insights into its shared biology with schizophrenia.

PI_NAMEs: ROBINETTE, MAXINE ISABELLA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: 22q11.2;3-Dimensional;Address;Affect;Alkynes;Antibodies;Axon;Biochemical;Biological;Biological Assay;Biology;Biotin;Cell Line;Cell Respiration;Cells;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Protein;Data;Defect;Dendrites;Development;DiGeorge Syndrome;Dyes;Electron Transport;Engineering;Etiology;experimental study;Faculty;fluorescence imaging;Galactose;gene product;Genes;Genetic;genomic locus;Genus Hippocampus;Glucose;Glycolysis;Heterozygote;high risk;Human;Image;Immunofluorescence Immunologic;Impairment;Incubated;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;innovation;insight;Label;Membrane Potentials;Mentorship;microdeletion;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Morphology;nerve stem cell;neural;neural model;Neurobiology;neurodevelopment;Neuroglia;neuron development;Neurons;novel;Nuclear;Process;Production;Protein Biosynthesis;protein expression;Protein Subunits;Proteins;Regulation;Reporting;Research;Resolution;Respiration;Ribosomes;Role;Schizophrenia;schizophrenia risk;small hairpin RNA;stem cell model;Stem Cell Research;Structural defect;Structure;Synapses;Syndrome;Techniques;Testing;Tissues;Titrations;Training;Translations;Visualization;Western Blotting

PROJECT_TITLE: Mitochondrial Defects in 22q11.2 Deletion Using a Human-Derived Neuronal Stem Cell Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE Cytomegalovirus (CMV) is a widespread virus that causes mild illness in healthy individuals but can cause serious disease in newborns, seniors and the immunocompromised. Multiple antibodies and vaccines to prevent CMV infection have failed in the clinic, which we hypothesize is at least partly due to the virus’ ability to capture and destroy anti-CMV antibodies. This project will evaluate strategies to disarm this viral defense strategy and thereby restore antibody activities against CMV that are expected to contribute to future effective treatments.

PI_NAMEs: MAYNARD, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affinity;Animal Model;Anti-viral Agents;Anti-viral Therapy;Antibodies;Antibody Activation;antibody engineering;Antibody Response;Antibody Therapy;Antibody titer measurement;antibody-dependent cell cytotoxicity;Antibody-mediated protection;Antigens;Binding;Binding Proteins;Biological Assay;Blocking Antibodies;Capsid Proteins;Cells;Chickenpox;Clinic;Clinical;Clinical Data;Clinical Trials;clinically relevant;Communicable Diseases;Congenital Abnormality;Cytomegalovirus;Cytomegalovirus Infections;Data;design;Development;Directed Molecular Evolution;Disease;ds-DNA;effective therapy;Engineering;Fab domain;Fc domain;Fc Receptor;Future;General Population;Genetic;Glycoproteins;Goals;Half-Life;Health;Hepatitis;Herpes Simplex Infections;Herpes zoster disease;Herpesviridae;high risk;high risk population;Homologous Gene;Human;Human Engineering;IgG1;Immune;Immune Evasion;Immunocompromised Host;Immunoglobulin G;In Vitro;in vivo;Individual;Infection;Infection Control;Infection prevention;inhibitor;insight;interest;Investments;Kinetics;Knowledge;latent infection;Licensure;Mediating;Monoclonal Antibodies;Morbidity - disease rate;mortality;neonatal Fc receptor;neutralizing antibody;Newborn Infant;Organ failure;organ transplant recipient;Outcome;particle;Passive Immunization;phase II trial;Pregnant Women;Prevalence;prevent;Prevention;Protein Engineering;Proteins;reactivation from latency;receptor;receptor binding;recruit;Research;Resistance;Role;seropositive;skills;standard care;Subunit Vaccines;T cell therapy;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;therapeutic vaccine;Toxic effect;Transplant Recipients;treatment strategy;Vaccination;Vaccine Antigen;vaccine evaluation;vaccine trial;vaccine-induced antibodies;Vaccines;Variant;Viral;Viral Physiology;Viral Proteins;Virus;Virus Receptors;Work

PROJECT_TITLE: Engineering potent antibodies against human cytomegalovirus

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Obesity

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Numerous studies support the premise that inflammation rises in aging. Drugs with immunomodulatory actions such as mechanistic Target of Rapamycin (mTOR) inhibitors may promote healthspan, the length of one’s life spent in good health, especially if given prior to onset of age-related declines. We will analyze deidentified samples from an NIA-funded clinical trial to test the possibility that the mTORC inhibitor everolimus is a safe and effective option to ameliorate age-related inflammation and sequelae thereof.

PI_NAMEs: NIKOLAJCZYK, BARBARA  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Age of Onset;age related;age related decline;age-related disease;Aging;aging biomarker;aging population;aging related;Ancillary Study;animal data;Animals;Bioenergetics;Blood;brain health;Cardiac;CCI-779;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Chronic;clinical practice;Clinical Trials;Cognition;Cognitive;cohort;Compensation;Complement;Complex;Confocal Microscopy;Coupled;cytokine;Data;Data Set;design;Disease;Dose;drug action;Effectiveness;Enrollment;Equilibrium;extend lifespan;Fostering;frailty;FRAP1 gene;Frequencies;Funding;gain of function;geroprotector;hallmarks of aging;Health;healthspan;healthy aging;Human;Immune;Immune response;immunoregulation;Immunosuppression;improved;In Vitro;Infection;Inflammaging;Inflammation;Inflammatory;influenza virus vaccine;inhibitor;innovation;insight;Institution;Insulin Resistance;Intervention;intervention effect;Lead;Length;lens;Life;Link;loss of function;Lysosomes;Mediator;Metabolic;Metabolism;middle age;Mitochondria;mitochondrial metabolism;muscle aging;Muscle function;Myeloid Cells;Obesity;older adult;Outcome;Outcome Study;Overweight;Oxidation-Reduction;Parents;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Placebos;Positioning Attribute;predictive modeling;prevent;Process;Production;Proteomics;Regimen;Research;Resources;Risk;Risk Management;Safety;Sampling;SDZ RAD;secondary analysis;senescence;Shipping;side effect;Signal Transduction;Sirolimus;Skeletal Muscle;Source;success;systemic inflammatory response;T-Lymphocyte;Testing;Tissues;vaccine response;Weight

PROJECT_TITLE: Impacting Inflammation through Mechanistic Target of Rapamycin (imTOR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-D (02)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative  CAR-T cell therapy has been proven effective in treating hematological malignancy and autoimmunity caused by B cell abnormality, but the cytotoxic and short-lived nature of CAR-T cells have become a major hurdle to this therapeutic strategy. We aim at improving longevity while reducing the cytotoxicity of CAR-T cells, by deletion or inhibition of the TCR signaling mediator ITK, which is a negative regulator of T cell survival and long- term memory functions. A better understanding of the role of ITK in CAR-T cell development and function, and new approaches to targeting ITK in CAR-T cells, will improve CAR-T cell production, therapeutic sustainability, and help expanding the therapeutic options for patients with cancer and/or autoimmune disorders.

PI_NAMEs: HUANG, WEISHAN  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Abnormal Cell;Affect;Affinity;Antigens;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Biological Markers;Biology;cancer therapy;CAR T cell therapy;CD19 gene;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Survival;Cells;Cellular biology;Cessation of life;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cost;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Development;Docking;Effector Cell;effector T cell;emt protein-tyrosine kinase;exhaustion;experimental study;Genes;Goals;Guide RNA;Health;Hematologic Neoplasms;Homeostasis;Human;immunopathology;improved;In Vitro;in vivo;Inbred BALB C Mice;Infusion procedures;innovation;Interleukin-2;Investigation;Knock-out;LCP2 gene;long term memory;Longevity;Lupus;Malignant Neoplasms;Mediator;Memory;Modeling;Molecular;Monitor;mouse model;Mus;Nature;neoplastic cell;next generation;novel;novel strategies;nucleofection;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;Phenotype;pre-clinical;prevent;Production;Proliferating;Proteins;Receptor Activation;receptor expression;Receptor Signaling;Research Proposals;retroviral transduction;Ribonucleoproteins;Risk;Role;Safety;side effect;Signal Pathway;Signal Transduction;src Homology Region 2 Domain;success;T cell response;T cell therapy;T memory cell;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Thinking;Tissue-Specific Gene Expression;Tissues;Toxic effect;transcriptome sequencing;translational applications;Treatment Efficacy;treatment response;tumor;Tumor Immunity;Tyrosine;Variant;Work;Xenograft procedure

PROJECT_TITLE: Modulation of ITK signaling for sustainable adoptive T cell therapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Estrogen;Kidney Disease;Organ Transplantation;Transplantation;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: We have found that estrogen therapy can protect against the development of kidney injury in animal models, and we plan to determine the mechanisms responsible for this protection and to test whether clinically approved selective estrogen receptor modulators (SERMs) can also be effective. We will also use insights from these murine studies to inform investigation in a separate study of women undergoing renal transplantation and receiving peri- operative estrogen therapy. These studies may have significance for the management of patients at risk of kidney injury due to a sudden decrease in blood supply or those undergoing renal transplantation.

PI_NAMEs: HANCOCK, WAYNE WILLIAM;LEVINE, MATTHEW HOWARD (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Allografting;animal imaging;Animal Model;Animals;antagonist;Biochemical;Blood Vessels;C-terminal;Cardiac;Cardiopulmonary Bypass;Cell Lineage;Cells;Cessation of life;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Coupled;delayed graft function;Development;Engraftment;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Eye;Failure;Female;Fibrosis;Functional disorder;Genetic;Goals;Graft Survival;GTP-Binding Proteins;Heart Arrest;human female;Immunosuppression;improved;Injury to Kidney;insight;Intervention;Investigation;Ischemia;Kidney;Kidney Transplantation;Ligand Binding Domain;male;Medical;Membrane;Morbidity - disease rate;mouse model;Mus;N-terminal;nephrogenesis;novel strategies;Nuclear Receptors;Operative Surgical Procedures;Osteoporosis;Outcome;Patients;Perioperative;Pharmaceutical Preparations;preservation;prevent;Process;Raloxifene;Renal function;renal ischemia;Reperfusion Injury;Risk;Selective Estrogen Receptor Modulators;sex;sexual dimorphism;Source;Specificity;Supportive care;Testing;Testosterone;Therapeutic Intervention;Tissues;Transactivation;transcriptomics;translational goal;translational potential;Trauma;Vascular blood supply;wiki;Women's study;Work

PROJECT_TITLE: Estrogen and Serms as Therapy for Renal Ischemia Reperfusion Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Cognitive decline is one of frequent challenges accompanying Alzheimer's disease. The goal of this study is to examine to what extent a frontal cognitive control circuit and associated network is vulnerable to early Alzheimer's disease pathology.

PI_NAMEs: MORISHITA, HIROFUMI  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: abeta accumulation;Acute;Adult;Affect;Age Months;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;Anterior;Area;Attention;attentional control;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavior Control;Calcium;cholinergic;cholinergic neuron;Cholinesterase Inhibitors;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cognitive control;Cognitive deficits;cognitive task;Development;Disease;donepezil;Event;Experimental Models;Fiber;Follow-Up Studies;frontal lobe;Functional disorder;Goals;Human;Image;Impaired cognition;improved;in vivo;insight;knock-down;Knock-in;Knock-in Mouse;Learning;Link;Maps;Memory;Memory Loss;Modeling;Monitor;Morphologic artifacts;mouse model;Mus;Muscarinics;mutant;neural;neural circuit;Neurons;neuroregulation;novel therapeutics;optogenetics;overexpression;Pathogenesis;Pathology;Performance;Photometry;Play;promoter;Rabies virus;Reaction Time;recruit;Role;sensor;Sensory;Signal Transduction;synaptic function;System;Testing;Time;Visual Cortex

PROJECT_TITLE: Dysregulated frontal-sensory network and cognitive control by Alzheimer's disease pathology

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: OMAHA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Migrant agricultural workers and their families experience persistent negative health consequences from the SARS-CoV-2 pandemic due to disparities in access to effective testing and treatment and pre-existing social and economic inequities; in response we have engaged rural migrant families in Nebraska to improve access to COVID-19 testing, healthcare, and community response resources through the Mobile Health for Migrant Health (mHealth-4-Mhealth) program. In the proposed study we will evaluate the impact, moderators, and cost- effectiveness of implementing mHealth-4-Mhealth program elements on migrant families’ access to and utilization of COVID-19 testing, treatment, and related healthcare resources. Given the portability and adaptability of mHealth tools to diverse communities, our findings can inform national-scale interventions to empower families to adapt to public health emergencies.

PI_NAMEs: MCCULLOH, RUSSELL JAMES (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: acceptability and feasibility;access disparities;Adoption;Agricultural Workers;Agriculture;Anti-viral Therapy;antigen test;arm;Behavior;bilingualism;Chronic;Cluster randomized trial;Collaborations;Communication;Communities;cost;cost effective;cost effectiveness;Coupled;COVID-19;COVID-19 pandemic;COVID-19 test;COVID-19 testing;COVID-19 treatment;COVID-19 vaccination;Diagnosis;Diagnostic Reagent Kits;Economics;Education;Effectiveness;effectiveness evaluation;Elements;Eligibility Determination;empowerment;Enrollment;Ensure;experience;Face;Family;Funding;Future;Geography;Health;health care service utilization;Health Policy;Health system;Healthcare;Home;home test;Household;Human;implementation determinants;Improve Access;improved;incremental cost-effectiveness;Individual;Inequity;infection management;infection risk;Institution;Intervention;intervention program;Knowledge;Linguistics;marginalized community;Medical;mHealth;Migrant;Nebraska;Outcome;pandemic impact;Participant;Policy Developments;portability;Preventive measure;primary outcome;Program Effectiveness;programs;prospective;Protocols documentation;public health emergency;public health intervention;RADx Underserved Populations;Randomized;randomized, clinical trials;Research;resilience;Resources;response;Rural;rural area;SARS-CoV-2 antigen;SARS-CoV-2 infection;screening;secondary outcome;Self Direction;social;social health determinants;Social isolation;Spanish/English;System;Testing;three-arm study;tool

PROJECT_TITLE: Mobile Health for Migrant Health (mHealth-4-Mhealth): Assessing the Effectiveness of Implementing an mHealth Program to Increase COVID-19 Testing and Treatment Among Rural Migrant Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Z (55)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The goal of this project is to capture dynamics of neural circuit formation, chronicle its functional and structural elements, and determine which maturational events are dependent on spontaneous action potential activity. Functional elements include the complement of ion channel expression and calcium signaling pathways to gene expression which underlie appropriate structural transformations that become the topographically correct neural circuit. These data, although focused on an important auditory brainstem neural circuit, provide a roadmap to understand severe developmental disorders that result from problems in early brain development, and to reorganize and possibly re-connect neurons in mature brains affected by injury or disease.

PI_NAMEs: SPIROU, GEORGE A (contact);VON GERSDORFF, HENRIQUE PRADO;YOUNG, SAMUEL MATTHEW

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Action Potentials;Affect;Auditory;autism spectrum disorder;Automobile Driving;Axon;Biological Models;Biophysics;Brain;Brain Stem;Calcium Channel;Calcium Signaling;Catalogs;Cell Nucleus;Cells;Closure by clamp;Communication;Complement;CREB1 gene;Data;Dendrites;Dependence;design;Development;developmental disease;Disease;Electron Microscopy;Elements;Event;experience;External auditory canal;Foundations;functional adaptation;Gene Expression;Genes;Glutamate Receptor;Goals;Grant;Growth;Image;Image Analysis;image processing;Imaging technology;Immunohistochemistry;Injury;insight;Intellectual functioning disability;interest;Ion Channel;large datasets;Link;Measurement;Medial;Mediating;Microscopy;Molecular;Nerve;nerve supply;neural;neural circuit;neuronal cell body;Neurons;Pathway interactions;Permeability;Phase;Phenotype;Phosphorylation;Physiological;postnatal;postsynaptic;presynaptic;prevent;Process;programs;Property;reconstruction;Research;Signal Pathway;Slice;Social disability;Specific qualifier value;Structure;Synapses;Synaptic Vesicles;System;temporal measurement;tetanospasmin;Tissues;transcription factor;transmission process;trapezoid body;vesicular release;Viral Vector;virus testing;voltage;voltage clamp

PROJECT_TITLE: Development of the Calyx of Held

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: We seek to understand the active processes that are responsible for normal hearing by building mathematical models simulating the behavior of the cochlea, the transducer of the hearing system. By understanding the cochlea well enough to model it, we hope to predict how the cochlea might fail, say in response to loud sound or age, and guide the development of protective approaches or enhanced prosthetics. In addition, a predictive mathematical model will enable the development of new noninvasive tests to better interrogate the health of one's hearing and may enable better speech recognition software or cochlear implant neural stimulation algorithms to be devised.

PI_NAMEs: GROSH, KARL  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acoustic Stimulation;Acoustics;Age;Algorithms;Amplifiers;Apical;base;Basilar Membrane;Behavior;Cell Physiology;Cells;Cochlea;Cochlear Implants;Communication;Complex;Coupled;Data;Dependence;Development;electric field;Electric Stimulation;Elements;experimental study;Failure;Feedback;Floor;Frequencies;Friends;Funding;Goals;Grant;Hair;Hair Cells;Health;Hearing;improved;in vivo;Inner Hair Cells;Intrinsic drive;Length;Link;Liquid substance;Loudness;Mammalian Cell;Mammals;mathematical model;Measures;Mechanics;Mediating;Modeling;Morphology;Motility;Music;Nature;neural stimulation;neurotransmitter release;Noise;Non-linear Models;noninvasive diagnosis;normal hearing;Optical Coherence Tomography;Organ;Organ of Corti;Outer Hair Cells;Pathology;Positioning Attribute;predictive modeling;pressure;Process;Prosthesis;Receptor Cell;Research;response;Rest;Rotation;signal processing;Signal Transduction;Somatic Cell;sound;Source;Speech;speech processing;Speech Recognition Software;Stimulus;Structure;System;tectorial membrane;Testing;Theoretical model;theories;Time;Transducers;vibration;voltage;Work

PROJECT_TITLE: Active and Nonlinear Models for Cochlear Mechanics

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Accumulation and misfolding of tau drives impairment in the autophagy lysosomal pathway (ALP) in Alzheimer’s disease and other related dementias. This proposal will develop two cellular fluorescence-based technologies that will monitor the kinetics of tau-induced ALP dysfunction by tracking the nuclear transport and dimerization of TFEB, the master regulator of ALP. These technologies will provide a platform for future biological questions and therapeutic discovery campaigns targeting critical steps within TFEB’s signaling cascade.

PI_NAMEs: SACHS, JONATHAN N (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Autophagocytosis;Autophagosome;Biogenesis;Biological;Biosensor;Cell Line;Cell model;Cell Nucleus;Cells;Classification;Communities;Complex;Dementia;design;differentiation protocol;Dimerization;Disease;DNA Binding;driving force;dynamic system;Engineering;Event;Fluorescence;Fluorescence Resonance Energy Transfer;Forskolin;Frontotemporal Dementia;Functional disorder;Future;Genes;Glutamates;Hand;high throughput screening;Homeostasis;Homodimerization;Human;human induced pluripotent stem cells;Image;Impairment;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Kinetics;Knowledge;Legal patent;Measurement;misfolded protein;Modeling;Molecular Neurobiology;Monitor;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Differentiation;Neuronal Dysfunction;Neurons;new technology;novel;Nuclear;Nuclear Import;Nuclear Translocation;nucleocytoplasmic transport;Organelles;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Physiological;Play;Positioning Attribute;Proteolysis;proteostasis;proteostasis loss;Publishing;Recycling;Regulation;Reporting;Research;Resolution;response;Role;Signal Transduction;Sleep;small molecule;Stress;System;targeted treatment;tau aggregation;tau expression;tau mutation;tau Proteins;Tauopathies;Technology;technology platform;Therapeutic;Time;tool;transcription factor;Translating;uptake

PROJECT_TITLE: Innovation in monitoring tau-induced dysregulation of the autophagy lysosomal pathway

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Infectious Diseases;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because: 1) it will directly lead to an improved understanding of how antiretroviral therapy (AVT) causes drug-hormone interactions in fragile patient population groups, including pregnant people, developing fetuses, and neonates and 2) it will provide mechanistic physiologically based pharmacokinetic (PBPK) to understand, predict, and prevent deleterious DHIs in these same groups. These achievements are directly related to the goals of the NIH to reduce human disease and suffering and make fundamental discoveries related to the improvement of human health.

PI_NAMEs: LAMPE, JED NOAH (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Achievement;Acute;Adrenal gland hypofunction;Adverse effects;Anti-viral Agents;Anti-viral Therapy;antiretroviral therapy;Attention;Bile Acids;Child;Chronic;Classification;Clinical;Complex;CYP3A4 gene;Cytochrome P450;Dehydroepiandrosterone Sulfate;Development;drug disposition;Drug Modelings;Endocrine;Enzyme Inhibition;Enzymes;Estradiol;fetal;Fetal Development;Fetus;Funding;Future;Glucuronosyltransferase;Goals;Growth;Health;Hepatic;Homeostasis;hormone metabolism;Hormones;Human;human disease;improved;infancy;Infant;Knowledge;Life;Lopinavir/Ritonavir;Low Birth Weight Infant;Metabolic;Metabolic Pathway;Modeling;Molecular;National Institute of Allergy and Infectious Disease;Neonatal;neonate;Neurodevelopmental Impairment;Newborn Infant;Outcome;Pathway interactions;patient population;Patients;pediatric patients;Persons;Pharmaceutical Preparations;pharmacokinetic model;Pharmacologic Substance;Physiological;physiologically based pharmacokinetics;Population Group;Pregnancy;pregnant;prevent;Process;Progesterone;Public Health;Regimen;Reporting;Research;research study;Risk;risk prediction;Risk Reduction;Safety;Signal Pathway;steroid hormone;steroid hormone biosynthesis;Steroids;success;Toxic effect;Toxicology;United States National Institutes of Health;Viral;viral transmission;Virus Diseases;Vulnerable Populations;women's outcomes

PROJECT_TITLE: Understanding the underlying toxicological mechanisms of drug-hormone interactions to improve the safety profile of antiviral medications in pregnant people, developing fetuses, and neonates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative We have shown that prior exposure to S. aureus leads to blunted humoral and cellular staphylococcal vaccine responses. Here we test the hypothesis that IL10 induced by prior S. aureus exposure underlies the non-protective T and B cell responses to S. aureus vaccines.

PI_NAMEs: LIU, GEORGE Y (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acetylation;Address;Adjuvant;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Response;Antibody titer measurement;Antigens;B-Lymphocytes;Cell Lineage;Cell Wall;Cellular Immunity;Clinical;Combined Vaccines;Data;Dependence;Development;efficacy evaluation;exposed human population;Exposure to;Fab domain;Failure;Fc domain;Generations;Genus staphylococcus;glycosylation;Human;Immune;Immune Evasion;Immunity;imprint;improved;infancy;Infection;insight;Interleukin-10;Laboratory mice;Link;Macrophage;Mediating;Modeling;Modification;Molecular;Mus;Myeloid Cell Activation;Neuraminidase;neutrophil;outcome prediction;pathogen;pathogen exposure;Peptidoglycan;Polysaccharides;pre-clinical;Predisposition;Production;Resistance;response;Serum;sialylation;Source;Staphylococcal Vaccines;Staphylococcus aureus;Staphylococcus aureus infection;T-Lymphocyte;Testing;Therapeutic;Time;Vaccination;Vaccine Antigen;vaccine development;vaccine efficacy;vaccine evaluation;vaccine failure;vaccine response;vaccine trial;Vaccines

PROJECT_TITLE: Mechanisms of vaccine interference by S. aureus-induced imprints

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Tendon pathologies are common and result from degeneration, injuries, failure to heal and aging. This proposal is a multiday meeting sponsored by ORS Tendon Section to provide a forum to present and discuss innovative research, to identify and develop consensus statements on emerging technologies, improve relevance, rigor, and reproducibility.

PI_NAMEs: AMADIO, PETER C.;GINGERY, ANNE  (contact);ZHAO, CHUNFENG

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Aging;aging mechanism;aging population;Animal Model;Area;arm;Automobile Driving;Basic Science;Biochemical;Biological;Biology;Biomechanics;career;Clinic;Clinical;Clinical Research;clinically relevant;Collaborations;Complex;Connective Tissue;Connective Tissue Diseases;Consensus;Consensus Development;Cumulative Trauma Disorders;Dense Connective Tissue;Development;Developmental Biology;Diagnosis;Discipline;Disease;effective therapy;Emerging Technologies;Engineering;Environment;Equity;equity, diversity, and inclusion;evidence base;Exposure to;Failure;falls;Fostering;frontier;Funding;Future;Goals;Grant;Growth;Guidelines;healing;Health;health disparity;healthspan;Histologic;Homeostasis;Image;image guided;Imaging technology;improved;Incidence;Injury;innovation;Interdisciplinary Study;interest;Journals;Lead;life span;Ligaments;Manuscripts;Mechanics;meetings;Mentors;Metabolic;Mission;Movement;multiple omics;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;next generation;Operative Surgical Procedures;Orthopedics;Outcome;Pain;Paper;Pathogenesis;Pathology;patient mobility;Patient-Focused Outcomes;Pennsylvania;Physical therapy;Pre-Clinical Model;Prevalence;Prevention;Publications;Publishing;repaired;Reproducibility;Research;Research Personnel;response to injury;Societies;Stress;success;symposium;Tendon Injuries;Tendon structure;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy outcome;Time;tissue injury;Tissues;Training;translational model;Translational Research;translational scientist;United States National Institutes of Health;Universities

PROJECT_TITLE: ORS Tendon Conference 2024: Mechanism to Therapy – Emerging Technologies and Therapeutic Outcomes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Topical Microbicides

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: This proposal identifies GW8510 as a new and functionally improved analog of BX795, which inhibits ocular herpes infection. This small molecule can strongly inhibit as well as synergistically enhance the efficacy of clinical antivirals. We will use GW8510 to study proviral mechanisms in the cornea and improve our understanding of its safety and efficacy in murine eyes using lab and clinical strains of ocular HSV-1.

PI_NAMEs: SHUKLA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Adverse drug effect;Aftercare;analog;Anti-viral Agents;anti-viral efficacy;Anti-viral Response;Anti-viral Therapy;antiviral drug development;Binding;Binding Proteins;Biological Assay;Cell Cycle;Cells;cellular targeting;Clinical;clinical application;clinical efficacy;Clinical Research;clinically relevant;combat;Combined Modality Therapy;Cornea;Curiosities;Data;design;Development;Disease;drug candidate;drug development;Drug Kinetics;Eukaryotic Initiation Factor-4E;Evaluation;Exhibits;Eye;Eye Infections;FDA approved;Formulation;functional improvement;Funding;Ganciclovir;Genetic Transcription;Goals;grasp;Health;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Herpetic Keratitis;improved;in silico;In Vitro;in vivo evaluation;Infection;inhibitor;innovation;insight;Investigation;Life Cycle Stages;meter;Molecular;Morbidity - disease rate;mouse model;Mus;novel;nucleoside analog;Oral;Oral Administration;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Phase;Positioning Attribute;pre-clinical assessment;Property;Protein Biosynthesis;Protein Inhibition;Proteins;Proteome;Proteomics;Proto-Oncogene Proteins c-akt;Research;Resistance;Resources;Retina;Rodent Model;Safety;safety assessment;satisfaction;Simplexvirus;small molecule;synergism;TANK-binding kinase 1;Therapeutic;tool;topical antiviral;Topical application;Toxic effect;transcriptomics;translational impact;Trifluridine;valacyclovir;Viral;Viral Genes;Viral Genome;Viral Physiology;Viral Proteins;Virus Replication;Vision

PROJECT_TITLE: A new molecular therapy against ocular herpes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative: In the midst of an unprecedented and escalating crisis of drug-related maternal morbidity and mortality in the US, public health has yet to generate the essential evidence needed to develop interventions to help people who use drugs (PWUD) survive pregnancy and the postpartum year. The proposed longitudinal (2017-2022) study is thus designed to support a new arena of interventions to help PWUD survive these 21 months of pregnancy and the postpartum year by generating essential evidence about (1) which drug-related harms PWUD suffer while pregnant/postpartum; (2) when during these highly dynamic 21 months these harms occur; (3) who suffers these drug-related maternal harms, overall and within subpopulations defined by race/ethnicity, insurance status, and rurality; (4) where PWUD experiencing these harms cluster spatially; and (5) the features of the “risk environments” where pregnant/ postpartum PWUD live that may elevate vulnerability to these harms.

PI_NAMEs: COOPER, HANNAH LF (contact);KRAMER, MICHAEL ROOT

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Advocate;Affect;Amphetamines;Autopsy;Bayesian Modeling;Behavioral;Cause of Death;Cessation of life;Clinical;Country;Data;Databases;Death Certificates;Death Rate;design;Development;Diagnosis;Disparity;drug metabolism;Drug usage;Drug user;Economics;Endocarditis;Environment;Epidemic;Ethnic Origin;experience;Family;General Population;Generations;Geography;Harm Reduction;harm reduction programs;high risk population;Hospitals;Incidence;Income;innovation;Insurance Coverage;Intervention;Interview;Investigation;Justice;Law Enforcement;Letters;Longitudinal Studies;marginalization;marginalized population;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Medical;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Needle-Exchange Programs;novel;opioid use disorder;Overdose;Persons;Pharmaceutical Preparations;Physiological;Population;Postpartum Period;Pregnancy;Pregnancy Trimesters;pregnant;psychologic;Public Health;public health intervention;Race;Records;reproductive;Research;Review Committee;Risk;risk selection;rurality;Services;Shapes;social;Social Work;Source;spatiotemporal;substance use;substance use treatment;System;therapy development;Time;tool;US State;Variant

PROJECT_TITLE: Substance use in PRegnancy and the mOrbidity Mortality rISk Environment (PROMISE)

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) Central to the etiology of disease processes leading to early pregnancy loss, preeclampsia, intrauterine growth restriction, placentae abruptio, and pre-term birth is abnormal development of the uterine-placental interface. Morphogenesis of the uterine-placental interface depends on differentiation and actions of the invasive/extravillous trophoblast cell lineage. Elucidation of mechanisms controlling invasive/extravillous trophoblast cell differentiation and its involvement in the development of the uterine-trophoblast cell interface will lead to the discovery of diagnostics for early detection of failures in the establishment of pregnancy and regulatory events that can be targeted for therapeutic intervention.

PI_NAMEs: SOARES, MICHAEL J (contact);TUTEJA, GEETU

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abate;Abbreviations;Abruptio Placentae;Activins;Affect;antagonist;beta catenin;carboxylesterase;Cell Differentiation process;Cell Lineage;cell type;Cells;Chromatin;Defect;Development;Developmental Process;Diagnostic;Disease;Early Diagnosis;early pregnancy loss;Elements;Embryo;Endothelial Cells;Environment;Etiology;Event;Failure;Fetal Growth Retardation;Follistatin;FSTL3 gene;genetic manipulation;genome-wide analysis;Goals;Human;Immune;Infertility;Infiltration;Invaded;loss of function;Modeling;Molecular;Morphogenesis;obstetrical complication;Pathogenesis;Pathway interactions;Patients;Phenotype;Placenta;Pre-Eclampsia;Pregnancy;Premature Birth;Process;Production;programs;Property;Proteins;Rattus;Regulation;Repression;Research Project Grants;Role;Smooth Muscle Myocytes;stem;Stromal Cells;targeted treatment;Therapeutic Intervention;transcriptome;trophoblast;trophoblast stem cell;Uterus;Villous;WNT Signaling Pathway

PROJECT_TITLE: Pathways Affecting Trophoblast Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This study examines the treatment and experiences of Medicaid patients who present to primary care clinics with back pain. The study aims to add to the understanding of racial and ethnic disparities in the use of evidence-based non-pharmacologic and other therapies for back pain.

PI_NAMEs: CHOO, ESTHER K (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Acceleration;Accounting;Acupuncture Therapy;Adult;Alaska Native;American Indians;Back;Back Pain;Black race;Caring;Categories;Characteristics;Chiropractor;chiropracty;Clinic;Cognitive Therapy;community-level factor;Data;Data Element;Development;Diagnosis;Diagnostic;disability;Disparity;Effectiveness;electronic health information;Electronic Health Record;Elements;ethnic disparity;ethnic minority;Ethnic Population;evidence base;expectation;experience;falls;Family Practice;Gender;Health Care Costs;health disparity;Health Services Accessibility;Health system;Hispanic;improved;Individual;Influentials;insight;Insurance Carriers;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Interview;Licensing;Linguistics;Literature;Location;Massage;Medicaid;medical specialties;Methods;minority patient;Modeling;Nonpharmacologic Therapy;Not Hispanic or Latino;Opioid;Oregon;outcome disparities;Pain management;Pain Measurement;Patients;Pattern;Pharmacotherapy;Physical therapy;Physician Executives;Policies;Population;Practice Management;Primary Care;primary care clinic;primary outcome;Procedures;Productivity;prospective;Provider;racial disparity;racial minority;racial population;recruit;Research Design;Retrospective Studies;Rural;Safety;Sampling;Schedule;Services;Site;social;suburb;Testing;Training;treatment disparity;United States National Institutes of Health;uptake;Visit;Work

PROJECT_TITLE: Unraveling Racial and Ethnic Disparities in Non-Pharmacologic Approaches for Medicaid Patients with Back Pain

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Genetics;Human Genome;Lung;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Our research focuses on the gas exchange region of lung, which is the site of injury in acute respiratory distress syndrome. By learning how different types of lung cells respond to damage from high pressure ventilation, we may be able to develop new and effective treatment approaches for respiratory failure.

PI_NAMEs: DESAI, TUSHAR JASUBHAI (contact);MATTHAY, MICHAEL A.

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Affect;Air;Alveolar;Alveolar Cell;Antibodies;aspirate;Autopsy;Back;Bacteria;Bacterial Infections;Bioinformatics;Biopsy;Blood;cell type;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;clinically relevant;cohort;comparative;Cytology;design;Detection;Diagnosis;Disease;Dysbarism;effective therapy;Endothelium;Engineering;Epigenetic Process;Epithelium;Gases;Gene Expression Profile;Genetic;Goals;Health Care Costs;high throughput screening;Histologic;Human;Hyperoxia;In Situ Hybridization;indexing;Individual;Infection;Injury;insight;intercellular communication;interest;Knowledge;Learning;Left;Ligands;Lipopolysaccharides;Liquid substance;Lung;Lung Diseases;lung injury;Machine Learning;Maps;Measures;Mesenchymal;Molecular;Molecular Analysis;Molecular Profiling;Morbidity - disease rate;Morphology;mortality;multimodality;multiple omics;Pathogenesis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Perfusion;Permeability;Phase;Phospho-Specific Antibodies;Physiological;Positioning Attribute;pressure;programs;Prospective Studies;Proteins;Pulmonary Edema;receptor;Recovery;repaired;Request for Proposals;Research;Research Personnel;Resolution;Respiratory Failure;response;Risk;Risk Factors;RNA;Sepsis;Severities;Signal Transduction;single cell genomics;single-cell RNA sequencing;Site;Slice;Sorting;Source;Stains;Structure of parenchyma of lung;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;Tidal Volume;Tissues;Transcript;transcriptomics;ventilation;Ventilator-induced lung injury

PROJECT_TITLE: Cellular and molecular mapping of ventilator-induced lung injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE The overall goal of this competitive renewal application is to build on our recent discoveries to gain further insight into the role of a specialized group of cells called TREM2 macrophages in protecting the kidney from the harmful effects of obesity-driven diabetic kidney disease.

PI_NAMEs: GREKA, ANNA  (contact)

PROJECT_TERMS: Address;Adopted;cell injury;Cells;Chronic;Chronic Disease;Chronic Kidney Failure;cohort;Complex;Coupled;Creatinine;Cues;curative treatments;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease Progression;Electron Microscopy;Exposure to;Functional disorder;glomerular basement membrane;Goals;hemodynamics;High Fat Diet;High Prevalence;Histology;Homeostasis;Human;Hypertension;Immune;Immune System Diseases;Incidence;Individual;Inflammation;inhibitor;Injury;Injury to Kidney;insight;Intervention;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;Kidney Failure;Link;Macrophage;Maps;Metabolic dysfunction;mouse model;Mus;Nephrectomy;Nephrons;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;novel therapeutics;obese patients;Obesity;Organoids;Patients;pharmacologic;Phenotype;Population;Predisposition;Proteinuria;Publishing;response;response to injury;Role;Sentinel;Surface;targeted agent;Testing;therapeutic target;Tissues;transcriptomics;TREM2 gene;Validation;Work

PROJECT_TITLE: Mechanisms of disrupted homeostasis and kidney injury


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: HEALTH RELEVANCE Chlamydia trachomatis is one of the most common causes of bacterial sexually transmitted infections and the leading cause of infectious blindness worldwide. Identifying how C. trachomatis promotes the fusion of its inclusions and characterizing the molecular regulation of the fusion machinery will provide invaluable insight into the mechanisms of disease progression. Furthermore, identifying the molecular machinery used by Chlamydia to promote membrane fusion will generate critical information for studying similar events with other intracellular human pathogens.

PI_NAMEs: PAUMET, FABIENNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Affect;animal data;Animal Model;Bacteria;Bacterial Proteins;Blindness;Cells;Cellular Structures;Chimeric Proteins;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Clinical;Clinical Data;Closure by clamp;Custom;Data;design;Development;Disease;Disease Progression;Ensure;Environment;Eukaryotic Cell;Event;fitness;Health;HIV;Homeostasis;Human;Human Cell Line;human pathogen;Immune response;Immunologics;Impairment;In Vitro;in vitro Assay;Infection;Infection prevention;Infertility;insight;Interferon Type II;Knowledge;Libraries;Life Cycle Stages;Life Style;Lipids;Malignant neoplasm of cervix uteri;Mammalian Oviducts;Mediating;Membrane;Membrane Fusion;Molecular;Mus;Mutate;neglect;novel;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathologic;Pathway interactions;Patients;Play;Positioning Attribute;Process;Proteins;Regulation;reproductive;Risk;Role;Sexually Transmitted Diseases;Site;Specificity;Stress;stressor;Structure;Surface;Symptoms;System;Testing;Time;Tissues;tool;Vaccines;Viral;Viral Fusion Proteins;Virulence;Virus;World Health Organization

PROJECT_TITLE: Regulation of homotypic fusion by Chlamydia

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Relevance to public health: Candida albicans is a major human fungal pathogen responsible for both mucosal and systemic infections in a wide variety of immunocompromised individuals. This proposal seeks to determine how translational mechanisms control the ability of C. albicans to tolerate a variety of different host environmental stess conditions and undergo filamentous growth, promoting virulence and pathogenicity. Ultimately, this study will provide new information leading to the development of novel and more effective strategies for the treatment of candidiasis.

PI_NAMEs: KADOSH, DAVID  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 5' Untranslated Regions;Acquired Immunodeficiency Syndrome;Address;Affect;anti-fungal agents;Antibiotics;Area;Binding;Binding Proteins;Binding Sites;biological adaptation to stress;Biological Assay;Cancer Patient;Candida albicans;Candidiasis;Cells;chemotherapy;combat;Complex;Conditioned Reflex;Cues;Defect;Development;Disseminated candidiasis;environmental stressor;Eukaryotic Initiation Factor-4F;Filament;Fluconazole;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;helicase;HIV/AIDS;Hospitals;Human;Immunocompromised Host;Individual;Infection;Invaded;Macrophage;Mass Spectrum Analysis;Mediating;Membrane;Messenger RNA;Microbial Biofilms;Morphogenesis;Morphology;mouse model;mRNA capping;Mucous Membrane;mutant;Mutation;neutrophil;novel;Oral candidiasis;organ transplant recipient;Orthologous Gene;Pathogenesis;pathogenic fungus;Pathogenicity;Patients;Pharmaceutical Preparations;Play;Point Mutation;Post-Translational Protein Processing;Predisposition;protein function;Proteins;Public Health;Regulation;Regulon;response;ribosome profiling;Ribosomes;RNA Cap-Binding Proteins;Role;Saccharomyces cerevisiae;Sepsis;Signal Pathway;Stress;Structure;Systemic infection;Testing;Tissues;Transcript;Transcriptional Regulation;Translational Regulation;Translations;treatment strategy;Virulence;Virulence Factors;Yeasts

PROJECT_TITLE: Translational Control of Host Environmental Stress Responses in Candida albicans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE The inaugural Science of Community Outreach and Engagement (SoCOE) Conference is proposed by six NCI-designated Cancer Centers to provide a platform for Community Outreach and Engagement (COE) academic-clinical-policy-community stakeholders to share best practices and recommendations that will address inequities in cancer prevention, early detection, care and survivorship. The SoCOE is an annual conference, with the 1st conference proposed to be hosted by the Mayo Clinic Comprehensive Cancer Center and the Virginia Commonwealth University Massey Cancer Center from May 8 to 10, 2024, in Florida, United States.

PI_NAMEs: ASHING, KIMLIN TAM;BASKIN, MONICA L.;ODEDINA, FOLAKEMI T (contact);RHOADS, KIM FELDER;SHEPPARD, VANESSA B;THOMPSON, HAYLEY S.

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;Administrator;Adoption;Advocate;Affect;African ancestry;anti-cancer research;Asian;Award;Birth;Black Populations;Black race;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;Caring;Catchment Area;City of Hope Comprehensive Cancer Center;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community center;community engaged approach;community engagement;Community of Practice;Community Outreach;Comprehensive Cancer Center;Country;Decentralization;design;Development;Discrimination;Early Diagnosis;Education;Enrollment;Ethnic Origin;Evidence based intervention;Family;Florida;Fostering;Funding;Funding Mechanisms;gender minority group;Genetic;Goals;Health;health disparity;health equity;Hispanic;Hispanic Populations;human capital;Immigrant;Indigenous;Inequity;Information Systems;innovation;Institution;Knowledge;knowledgebase;Lead;Learning;Letters;Malignant Neoplasms;marginalized community;marginalized population;meetings;member;Minority;minority communities;Minority Groups;mutual learning;National Cancer Institute;Oncology;Outcome;Participant;Persons;Policies;precision oncology;programs;Published Comment;Publishing;racism;Recommendation;recruit;Regulatory Pathway;Research Personnel;Residencies;Resources;Risk Factors;Rural;Rural Community;Scholarship;Science;Series;Sex Orientation;Sexual and Gender Minorities;social health determinants;Strategic Planning;Survivors;survivorship;Sustainable Development;symposium;theories;tool;United States;United States National Institutes of Health;Universities;University of Pittsburgh Cancer Institute;Virginia

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative With a team of collaborators, we propose to use state-of-the-art approaches to dissect the mechanisms underlying blood cell formation. Specifically, the proposed studies address a gap in our knowledge as to how red blood cells and platelets are formed in the bone marrow. The results of the proposed studies hold significant promise for the development of novel therapeutic treatments for blood diseases.

PI_NAMEs: KRAUSE, DIANE S (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Affect;ATAC-seq;Binding;Blood Platelets;blood treatment;Bone Marrow;CDK9 Protein Kinase;cell type;Cells;Cellular biology;Chromatin;Cleavage Under Targets and Release Using Nuclease;clinical application;Collaborations;Data;Detection;Development;differential expression;Epigenetic Process;Erythrocytes;Erythroid;Erythroid Progenitor Cells;GATA1 gene;Genes;Genetic Transcription;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic stem cells;Human;human stem cells;innovation;knock-down;Knowledge;Maps;Mediating;Megakaryocytes;Megakaryocytopoieses;Molecular;Molecular Biology;Mutate;novel therapeutics;Phosphorylation;Phosphorylation Inhibition;Phosphorylation Site;Phosphoserine;Phosphotransferases;Production;Productivity;progenitor;promoter;Proteomics;Publishing;Recommendation;Regulation;Research;RNA;RUNX1 gene;Serine;Serine/Threonine Phosphorylation;Sorting;Specific qualifier value;stem cell biology;stem cell fate;stem cell fate specification;stem cell population;stem cells;Technology;Testing;Text;Therapeutic Intervention;Threonine;Transcription Elongation;transcription factor;Transcription Initiation;transfusion medicine;upstream kinase;XCL1 gene

PROJECT_TITLE: RUNX1-mediated regulation of MEP fate specification

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: Project Narrative Exposure to stress is one of the leading causes of mental illnesses like Major Depressive Disorder, Post- Traumatic Stress Disorder, and many anxiety disorders. Understanding the neurobiological and neuroendocrine mechanisms that link the stress response to long-term clinical outcomes is therefore a primary challenge for the field of neuroscience and psychiatry, and this meeting allows stress researchers to share their findings, network, and learn from each other with the ultimate goal of informing therapeutic development.

PI_NAMEs: CHRISTIANSON, JOHN PAUL (contact)

PROGRAM_OFFICER_NAME: MEZA-CERVERA, TATIANA

PROJECT_TERMS: Adolescence;Age;Anxiety Disorders;Award;Basic Science;Behavioral;biological adaptation to stress;Black, Indigenous, People of Color;Boston;career;career development;Clinical;Collaborations;college;cost;Data;Dedications;Development;disadvantaged background;Discipline;Dissection;Diverse Workforce;early-career faculty;Educational workshop;emotional symptom;experience;Exposure to;Faculty;Feedback;Financial Support;Fostering;Functional Magnetic Resonance Imaging;Funding;gender minority;Goals;Grant;health disparity;hormonal signals;Human;insight;Institution;Institutional Racism;Investigation;Knowledge;Laboratories;Latino;Learning;Lesbian Gay Bisexual Transgender Queer;Light;Link;Major Depressive Disorder;Massachusetts;Mediating;Medical center;meetings;mental development;Mental disorders;Mental Health;Mentors;Minority;minority communities;Minority Groups;Mus;neural;neural circuit;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;Neurosciences;Neurosecretory Systems;Outcome;Participant;Persons;Play;Politics;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;posters;programs;Psychiatry;Public Health;racial minority;racism;Research;Research Personnel;Research Subjects;Risk Factors;Role;Schizophrenia;Scientific Inquiry;Scientist;sexual minority;steroid hormone;Stream;Stress;stressor;Structure;Students;Substance abuse problem;symposium;therapeutic development;Therapeutic Intervention;Titan;Translating;Trauma;Travel;undergraduate student;Universities;Vision;Woman;Work

PROJECT_TITLE: Neurobiology of Stress Workshop

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (G2)]


NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Atrial fibrillation (AF) leads to high health economic burden of >$15 billion for new onset AF and an annual cost of $6.65 billion for the care of these patients. Improved identification of risk factors from multimodal data can help select patients who will most benefit from invasive therapy, thus providing a cost-effective approach to management of AF.

PI_NAMEs: CHIAMVIMONVAT, NIPAVAN  (contact);FILKOV, VLADIMIR ;SRIVATSA, UMA

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Ablation;Acids;acute coronary syndrome;Age Years;Aging;aging population;Algorithms;Anti-Inflammatory Agents;Anticoagulation;Antiinflammatory Effect;Arachidonic Acids;Area;Arrhythmia;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Atrial Fibrillation;Biological;Biological Markers;Blood;Blood specimen;Cardiovascular Diseases;Caring;Catheters;CCL11 gene;CCL2 gene;CCL3 gene;CCL4 gene;chemokine;Clinical;Clinical Data;Clinical Trials;Code;cohort;Color;comorbidity;Complex;Consent;Consumption;convolutional neural network;cost;cost effective;CXCL10 gene;Cytochrome P450;cytokine;Data;Data Analyses;data modalities;Data Science;Data Set;density;Diabetes Mellitus;Dinoprostone;Disease;Economic Burden;Electrodes;Enrollment;Epoprostenol;Evolution;Fibrosis;flexibility;Fractionation;Goals;health economics;Heart Atrium;Heart failure;Hospitalization;human old age (65+);Hypertension;Image;improved;Inflammation;Inflammatory;inflammatory marker;Interleukin-1;Interleukin-10;Interleukin-11;Interleukin-13;Interleukin-4;Interleukin-6;Intracardiac abnormalities;Investigation;Label;Learning;Left;Left atrial structure;Leukotrienes;Linoleic Acids;Lipoxygenase;Logistic Regressions;Lung Diseases;Machine Learning;machine learning model;Maps;Measurement;Measures;metabolomics;Methods;Modeling;Modification;Molecular;Morbidity - disease rate;Morphology;mortality risk;multimodal data;multimodal learning;multimodality;Myocardium;neutrophil;Obesity;Outcome;Pathogenesis;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Pharmacologic Substance;predictive modeling;Procedures;Prognosis;Property;prospective;Prostaglandin-Endoperoxide Synthase;Prostaglandins;random forest;RANTES;Recurrence;Refractory;Retrospective Studies;Risk;Risk Factors;risk prediction model;Risk Reduction;Sensitivity and Specificity;Severities;Signal Transduction;Sinus;Site;Sleep Apnea Syndromes;Spatial Distribution;Stroke;Symptoms;Techniques;Testing;therapeutic target;Thromboxanes;Time;TNF gene;Translating;Treatment Failure;voltage

PROJECT_TITLE: Molecular Mechanisms of Atrial Fibrillation: A Multimodal Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-C (02)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Services;Hematology;Machine Learning and Artificial Intelligence;Rare Diseases;Sickle Cell Disease

ORG_CITY: FAYETTEVILLE

ORG_NAME: CELLIA SCIENCE, INC.

ORG_STATE: AR

PHR: Project Narrative Bone marrow aspirates are critical to the diagnosis, staging, and monitoring of hematologic conditions and cancers (e.g., leukemia, aplastic anemia, sickle cell disease, and metastasis of solid tumors), but 8-50% of aspirations are unsuccessful due to operator technique, hemodilution, or underlying pathology. Cellia Science will enable improved quality and reliability of bone marrow aspiration procedures by developing an automated point-of-care instrument for assessment of sample adequacy. Successful implementation of this device is expected to increase the fraction of successful procedures, which will drastically improve the quality of care for the patient.

PI_NAMEs: ROBLES, FRANCISCO E (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Address;Adopted;Adoption;Algorithms;analysis pipeline;Aplastic Anemia;Architecture;Area;aspirate;Assessment tool;attenuation;automated algorithm;bone;bone imaging;Bone Marrow Aspiration;cellular imaging;Characteristics;Classification;Clinical;Collection;commercial launch;Complement;cost;Data;deep learning algorithm;design;Detection;Development;Device Designs;Devices;Diagnosis;Diagnostic;Ensure;Eye;feature extraction;Feedback;functional improvement;Future;Giemsa stain;Goals;Hematology;Hemodilution;Human;Image;improved;innovation;instrument;Interview;Label;Left;leukemia;Light;Machine Learning;Malignant Neoplasms;Manuals;manufacturability;manufacture;Methods;Microscopy;Monitor;Neoplasm Metastasis;Optics;parent grant;Pathology;Patient-Focused Outcomes;Patients;Persons;point of care;Population;Procedures;Process;Protocols documentation;prototype;Quality of Care;Research;Research Personnel;response;Safety;Sampling;Science;screening;Sensitivity and Specificity;sensor;Sickle Cell Anemia;Slide;Solid Neoplasm;Specific qualifier value;Specificity;Speed;Staging;success;Techniques;Technology;Time;time use;Training;ultraviolet;Underrepresented Populations;usability;Visual;Work

PROJECT_TITLE: Deep-UV Microscopy for Real-Time Adequacy Analysis of Bone Marrow Aspirates


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: In the AYA Access Study we will evaluate if a theoretically and stake-holder informed enhanced eHealth and chatbot enabled delivery model can increase uptake of genetic services and provide non-inferior patient reported outcomes as compared to the standard model for remote genetic services in AYA cancer patients in community cancer practices. We expect this research to significantly inform how best to increase adherence to genetic testing guidelines among AYA while maintaining adequate patient outcomes and improving the quality of cancer care.

PI_NAMEs: BRADBURY, ANGELA R. (contact);HENDERSON, TARA OLIVE

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Affective;Age;arm;behavioral outcome;Biology;cancer care;cancer diagnosis;cancer genetics;cancer predisposition;Caring;chatbot;Clinical Trials;Cognitive;Collaborations;Communication;Communities;Community Clinical Oncology Program;Community Hospitals;Community Practice;community setting;Consolidated Framework for Implementation Research;cost;Counseling;design;Diagnosis;Distress;Education;efficacy evaluation;eHealth;Eligibility Determination;Enrollment;ethnic minority;Future;future implementation;Genetic;Genetic Counseling;genetic counselor;Genetic Models;Genetic Services;genetic testing;Germ-Line Mutation;Goals;Guidelines;Health behavior;health care delivery;implementation barriers;improved;improved outcome;Inferior;Infrastructure;innovation;Integrated Health Care Systems;Intervention;intervention delivery;Knowledge;Malignant Neoplasms;Medical;Medical Genetics;Methods;Minority;model building;Modeling;multimodality;National Cancer Institute;National Comprehensive Cancer Network;novel;older patient;Oncology;Online Systems;Outcome;Pathogenicity;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Population;primary endpoint;primary outcome;process evaluation;programs;Provider;racial minority;Randomized;Recommendation;recruit;Research;rural dwellers;Screening for cancer;secondary outcome;Service delivery model;service uptake;Services;Site;sociodemographic factors;Standard Model;Susceptibility Gene;Technology;Testing;testing uptake;treatment arm;treatment as usual;underserved community;uptake

PROJECT_TITLE: AYA ACCESS Study: An enhanced eHealth and Chat-bot enabled delivery model for clinical genetic services in community AYA cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Type 2 diabetes is a costly and complex chronic illness and a serious public health problem, responsible for a host of complications that significantly decrease healthy lifespan. The underlying issue in diabetes is the failure of specific cells in the pancreas, termed β-cells, to release enough of the hormone, insulin, into the bloodstream to properly control blood sugar levels. The aims of this proposal are to characterize emerging cellular targets to promote β-cell cell health and proper insulin release, ultimately improving the care and treatment of individuals with type 2 diabetes.

PI_NAMEs: KIMPLE, MICHELLE E (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Agonist;Arachidonic Acids;Area;Beta Cell;Binding;Biochemical;Biological Assay;Blood Circulation;Blood Glucose;Caring;Cell Physiology;Cell Proliferation;Cells;Cellular biology;cellular imaging;cellular targeting;Child;Chronic;Chronic Disease;Clinical;Compensation;Complex;Confocal Microscopy;cost;Critical Pathways;Cyclic AMP;Data;Diabetes Mellitus;diabetes mellitus therapy;Diabetes prevention;Diabetic mouse;Dinoprostone;Enzymes;Failure;Foundations;Functional disorder;functional loss;Future;G-Protein-Coupled Receptors;GLP-I receptor;glucagon-like peptide 1;Glucose;Goals;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Health;healthspan;Hormones;Human;Image;improved;Individual;innovation;Insulin;insulin secretion;islet;lifetime risk;Link;Measurement;Membrane;Metabolic;metabolome;metabolomics;Methods;Microscopy;Molecular;Monomeric GTP-Binding Proteins;Mus;mutant;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obese Mice;Obesity;Organ Donor;Pancreas;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;Play;preservation;prevent;Production;programs;Proliferating;Prostaglandins;Proteomics;Public Health;Publishing;Qualifying;receptor;Research;response;Rodent;Role;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Structure of beta Cell of islet;Techniques;Testing;Therapeutic;Thinness;Time;Tissues;Variant;Visualization;Work

PROJECT_TITLE: The role of G protein-dependent and -independent EP3 signaling in beta-cell compensation and diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Rare Diseases;Tuberous Sclerosis

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The mechanisms underlying complex neurodevelopmental condition-relevant behaviors remain poorly understood. In this proposal, we will delineate neural circuit mechanisms that contribute to critical behaviors such as social behaviors; delineate potential benefits of neural circuit modulation to these behaviors; and provide a better mechanistic understanding of the networks, communication, and function of cerebellar-medial prefrontal circuits in the regulation of social behaviors.

PI_NAMEs: TSAI, PETER T. (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Anatomy;Animals;Behavior;Behavioral;Cells;Cerebellar Diseases;Cerebellum;clinically relevant;CNTNAP1 gene;Communication;communication behavior;Communication impairment;Complex;critical period;Data;Defect;Development;flexibility;Foundations;Funding;Genes;Genetic;Genetic Models;Grant;human disease;Impairment;improved;in vivo;Medial;Mediating;Modeling;Motor;mouse model;Mus;mutant;Mutant Strains Mice;Nature;neural;neural circuit;Neurons;neuroregulation;Neurosciences;optogenetics;Performance;Physiological;Play;postnatal;pre-clinical;Prefrontal Cortex;prevent;Process;Publishing;Purkinje Cells;Regulation;repetitive behavior;Reporting;Role;Signal Transduction;social;Social Behavior;social deficits;Social Interaction;Time;TSC1 gene;Tuberous Sclerosis;Work

PROJECT_TITLE: Cerebellar-Cerebro Cortical Circuits in Social Behaviors

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOCHEMISTRY

PHR: Public Health Relevance: Spinal and bulbar muscular atrophy (SBMA) is one of 9 polyglutamine diseases that are part of a larger family of neurodegenerative diseases characterized by protein misfolding and accumulation; these diseases include Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). We have begun to characterize the mutant AR interactome – both stable and transient interactors – in a cell model of SBMA and propose here to continue this identification in novel human cell models, to validate these identified proteins in vivo, and to further these studies by exploring the detailed mechanistic basis for one of these interactors, USP7, and for other interactors uncovered by these studies. Finally, with the additional study and understanding of the therapeutic potential of targeting the USP7-AR interaction in SBMA models, the sum of these studies represents a powerful approach to uncover the underlying mechanisms of disease in SBMA.

PI_NAMEs: MERRY, DIANE E (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylation;Adult;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Androgen Receptor;androgenic;Androgens;Animal Model;Arginine;Binding;Biochemical;Biotin;Brain Stem;Cell Culture Techniques;Cell Death;Cell model;Cell Nucleus;Cell Physiology;Co-Immunoprecipitations;Consensus;Disease;disease model;Disease Progression;Drosophila genus;Evaluation;Event;Family;Functional disorder;Funding;Genetic;Hormones;Human;Huntington Disease;in vivo;Inclusion Bodies;Inherited;insight;Investigation;knock-down;Knock-in Mouse;Knowledge;Length;Ligands;Ligase;Link;Lysine;Metabolism;Methylation;Modeling;Molecular;Molecular Conformation;Motor Neurons;mouse model;Muscle;Muscular Atrophy;mutant;Neurodegenerative Disorders;neuromuscular;Neuromuscular Diseases;neuron loss;Neuronal Dysfunction;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Nuclear Inclusion;Onset of illness;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptides;Phosphorylation;polyglutamine;Post-Translational Protein Processing;Protein Conformation;protein misfolding;protein protein interaction;Proteins;Proteolysis;Proteomics;public health relevance;receptor;Receptor Aggregation;receptor function;Receptor-Interacting Protein;Role;Serine;Signs and Symptoms;Site;Specificity;spinal and bulbar muscular atrophy;Spinal Cord;Spinal Diseases;Spinocerebellar Ataxias;Stable Isotope Labeling;Sum;Therapeutic;therapeutic development;Therapeutic Effect;Tissues;Toxic effect

PROJECT_TITLE: The role of the AR interactome in SBMA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Responsive to the call for global team science and collaboration, the Global Perspectives on Developmental Science to Address Adolescent Resilience and Well-Being in the Face of Sociocultural and Ecological Challenge conference aims to integrate cutting-edge research regarding socio-cultural and ecological challenges confronting today’s adolescents and to guide policies, programs, and practices that best support resilience and well-being in youth around the world. To springboard the establishment of a sustainable community of global scholars, this conference provides a foundation for the creation of a global science research network in adolescent resilience and well-being, contextually- and culturally-relevant theoretical frameworks and methods for advancing that science, and support for a diverse cadre of scholars across the career trajectory to engage in and translate this work in ways that benefit local families and communities around the world.

PI_NAMEs: HUSSONG, ANDREA M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Acceleration;Acute;Address;Adolescence;Adolescent;Adolescent Development;Adopted;Anxiety;Atrocities;Awareness;career;Chicago;Child;Climate;Collaborations;Communities;Conflict (Psychology);Country;COVID-19 pandemic;Critiques;design;Development;Disasters;Distress;Ethnic Origin;Event;Exercise;Family;Feeling suicidal;Fostering;Foundations;Funding;Future;Gender;global health;Goals;Health;Human;Hybrids;Illinois;Immigration;improved;Individual Differences;innovation;Institution;International;lens;Manuals;meetings;Mental Depression;Mentorship;Methods;Mission;Modeling;National Institute of Child Health and Human Development;online version;Outcome;Pathway interactions;Personal Satisfaction;Persons;Policies;Process;programs;Psyche structure;Publishing;Race;Refugees;Research;resilience;Resources;school shooting;Science;science and society;Scientist;Sexuality;social culture;social media;Societies;Source;Strategic Planning;Structure;suicidal behavior;symposium;Thinking;trafficking;Training;Training Programs;Translating;vaccine development;Vaccines;War;Work;Youth

PROJECT_TITLE: Global Perspectives on Implications of Developmental Science to Address Adolescent Resilience to Sociocultural and Ecological Challenges

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_CITY: SAINT LOUIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Program Director/Principal Investigator (Last, First, Middle): GUAN, JIANJUN Project Narrative: Following myocardial infarction, the prolonged inflammation and uncontrolled cardiac fibrosis gradually deteriorate cardiac function. Thus, timely transitioning the proinflammatory phase to anti-inflammatory phase, and inhibiting cardiac fibrosis are crucial for improving cardiac function. However, the effective therapies to simultaneously achieve both goals remain to be established. This project will create and validate a conceptually new approach to address current limitations. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: GUAN, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Acute myocardial infarction;Address;Affect;angiogenesis;Anti-Inflammatory Agents;Antibodies;Area;Artificial nanoparticles;Attenuated;Binding;Biodistribution;Cardiac;cardiac repair;Cell Survival;cell type;Cells;Clinical Trials;Collagen;coronary fibrosis;cytokine;density;Deposition;Dose;effective therapy;efficacy testing;Encapsulated;Endothelial Cells;Fibroblasts;Fibrosis;Goals;Growth Factor;heart function;Human;improved;in vivo;Infarction;Inflammation;Inflammatory;inhibitor;Injections;Interleukin-1;Interleukin-1 Receptors;Intravenous;Ischemia;liver function;Macrophage;Modeling;Morphogenesis;Myocardial;Myocardial Degeneration;Myocardial Infarction;Myofibroblast;nanoparticle;nanoparticle delivery;novel strategies;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;Peptides;Pharmaceutical Preparations;Phase;prevent;Principal Investigator;programs;receptor;Renal function;Safety;Signal Transduction;spatiotemporal;Testing;Time;Tissues;Transforming Growth Factor beta;Treatment Efficacy

PROJECT_TITLE: Engineered nanoparticles to control inflammation and fibrosis after acute myocardial infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (03)]


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Systemic and structural racism within health systems and racial biases among health care providers and administrators are significant contributors to racial, ethnic and related inequities in health. Advancing anti-racist strategies requires health delivery systems (HDS) to partner with communities served by these institutions to gain necessary trust, co-design, and implement anti- racist practices. The proposed continuation of the ASTARISQ will be convened each year in an innovative, collaborative, and structured approach to achieve three aims: (1) Identify, prioritize, and co-design with impacted community members trainings on anti-racist strategies, policies, and practices to address structural racism in HDS to improve patient safety, quality of care, and trustworthiness in HDS; (2) Convene an interactive series of roundtables to train and prepare diverse stakeholder groups to address structural racism in HDS and health services research (HSR); and (3) Produce and disseminate guidance documents to equip participants and broader audiences with resources and skills in evidence-based, anti-racism-informed strategies to strengthen anti-racist policies and practices.

PI_NAMEs: EDWARDS, HILLARY ANNE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: ASTARISQ: Addressing systemic and STructurAl Racism to Improve Safety, Quality, and trustworthiness in health delivery systems

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Glioblastoma (GBM), the most common malignant brain cancer, is notorious for wide dissemination in the brain; how invading GBM cells achieve invasiveness is poorly understood. Here, we will explore novel mechanisms driving invasion of GBM cells through confined space by applying innovative microchannel devices, fluorescent probes, new molecular reagents and live-cell imaging. We will also conduct proof-of-concept in vivo studies of how perturbation of mechanoelectrical membrane dynamics may curb GBM invasion, thus forming new paradigms to study GBM mechanobiology and its translational potential.

PI_NAMEs: FRIEDEL, ROLAND HORST (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acceleration;Actins;Affect;anti-cancer research;Automobile Driving;Biological Assay;Biological Process;Biomechanics;Brain;brain parenchyma;cancer cell;Cell Communication;Cell Line;Cell membrane;cell motility;Cells;Cellular biology;Charge;Communities;Confined Spaces;constriction;Coupled;Coupling;Cytoskeletal Modeling;Cytoskeleton;Data;Device Designs;Devices;Disease;efficacy evaluation;efficacy study;Endocytosis;Endocytosis Inhibition;Endocytosis Pathway;F-Actin;Fluorescent Probes;Genetic Transcription;Glioblastoma;Glioma;high reward;high risk;in vivo;Infiltration;inhibitor;innovation;insight;Invaded;Link;Lipids;live cell imaging;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;Mediation;Membrane;Membrane Proteins;Mesenchymal;microdevice;migration;Molecular;Monitor;novel;novel therapeutics;Patients;Process;Proliferating;Property;Reagent;Recurrence;Regulation;release of sequestered calcium ion into cytoplasm;Research;Resolution;Role;Series;Speed;stem cells;Surface;Testing;Time;translational potential;transplant model;Transplantation;Tumor Cell Invasion

PROJECT_TITLE: Novel mechanisms of confined migration of GBM cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-S (02)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Fusobacterium nucleatum is associated with oral and extra-oral diseases, yet how this oral bacterium adapts to various metabolically changing environments to sustain its virulence potential is not well understood. Here, we will investigate formation of outer membrane appendages as a mechanism of metabolic adaption that enables F. nucleatum virulence. A better understanding of fusobacterial pathophysiology will aid the development of effective therapies against this oral pathogen.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinomyces;Adherence;Anaerobic Bacteria;appendage;Bacteria;Biochemical;Biogenesis;biological adaptation to stress;Breast;Breast Cancer Cell;breast cancer progression;Candidate Disease Gene;Cell Communication;cell growth;Cell Physiology;Cell surface;Cells;Colon;Colorectal;Colorectal Cancer;Cryoelectron Microscopy;Cues;Data;Defect;Development;Disease;effective therapy;Electron Microscopy;Environment;Exhibits;forward genetics;Functional disorder;Fusobacterium nucleatum;Future;Gene Deletion;Genetic;Genome;Human;Immunity;In Situ;In Vitro;in vivo Model;Infection;inhibitor;insight;interdisciplinary approach;Invaded;Investigation;Knowledge;Libraries;Link;Lipoproteins;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Proteins;Metabolic;Metabolism;Methods;microbial;Microbial Biofilms;migration;Molecular;molecular assembly/self assembly;Molecular Chaperones;Morphology;Motility;Muramidase;mutant;N-Acetylmuramoyl-L-alanine Amidase;Names;Nanostructures;Nutrient;Open Reading Frames;opportunistic pathogen;Oral;oral anaerobes;oral bacteria;oral biofilm;Oral cavity;oral microbial community;oral pathogen;Organism;Pancreas;pancreatic cancer cells;pathobiont;Peptidoglycan;Physiological;Pilum;Placenta;Play;Porphyromonas gingivalis;Premature Birth;Proliferating;protein protein interaction;Proteins;public health relevance;Reporting;response;reverse genetics;Rodent Model;Role;Site;Streptococcus;Stress;Structure;Surface;Symbiosis;System;targeted treatment;Testing;therapeutic development;Tissues;tomography;tool;trait;Tubular formation;tumor growth;Tumor Promotion;Virulence

PROJECT_TITLE: Assembly and function of outer membrane tubules in Fusobacterium nucleatum

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Hematology;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: Narrative (public health relevance statement): The grim prognosis and lack of therapeutic options for glioblastoma highlight the urgency of working towards developing novel treatment modalities. Myeloid-targeted therapies have been ineffective despite intensive research. This application will provide the unique opportunity to explore myeloid heterogeneity, the mechanisms driving their influx into tumors, and what drives current anti-myeloid targeted therapy resistance.

PI_NAMEs: HAMBARDZUMYAN, DOLORES  (contact)

PROJECT_TERMS: adaptive immunity;Address;Affect;Automobile Driving;Binding;Biological;Biological Assay;Blood;Blood Circulation;Bone Marrow;Brain;Brain Neoplasms;cancer therapy;Cell Communication;Cell Physiology;cell type;Cells;chemokine;Chemotaxis;Chemotaxis Induction;Circulation;Clinical;Coculture Techniques;Common Neoplasm;comparison control;Complement;CXCL1 gene;Data;design;Development;Dominant Genes;driver mutation;Endothelial Cells;Flow Cytometry;Foundations;Gene Expression Profile;Genetic;Genetic Heterogeneity;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genotype;Glioblastoma;Goals;Growth;Hematopoietic;Heterogeneity;Human;IL8RB gene;immune cell infiltrate;Immunologic Surveillance;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infiltration;Innate Immune System;Knowledge;life span;Macrophage;Malignant Neoplasms;Mesenchymal;Methods;Microglia;migration;Modality;Modeling;molecular subtypes;monocyte;mouse model;multiple omics;Mus;Myelogenous;Myeloid Cells;Necrosis;Necrosis Induction;neglect;neutrophil;Neutrophil Infiltration;NF1 gene;novel;PDGFB gene;pharmacologic;Play;Population;Production;Prognosis;Property;public health relevance;recruit;Research;Resistance;resistance mechanism;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Slice;small molecule inhibitor;spatiotemporal;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;TNF gene;TNFRSF1A gene;trafficking;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Validation

PROJECT_TITLE: Myeloid Recruitments and their Role in Brain Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: NARRATIVE Individuals with Substance Use Disorder often demonstrate a lack of consistency in choices, especially in the context of uncertainty. Our experiments are aimed at studying and manipulating the brain signals associated with learning under different forms of uncertainty using high-resolution tools and algorithms.

PI_NAMEs: IZQUIERDO, ALICIA  (contact);SOLTANI, ALIREZA

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Adaptive Behaviors;adaptive learning;Adopted;Adoption;Affect;Algorithms;Amygdaloid structure;Animals;Anterior;Arbitration;Behavior;Behavior Control;Behavioral;Brain;Calcium;Cells;Choice Behavior;Chronic;cingulate cortex;Computing Methodologies;Data;designer receptors exclusively activated by designer drugs;disorder risk;Endowment;Environment;Etiology;Exhibits;expectation;experience;experimental study;Foundations;frontal lobe;Funding;Future;Genetic;Human;Image;in vivo;Individual;Learning;Link;Measures;Modeling;Nature;neural;neurobehavioral;Neurons;novel;Outcome;Pathway interactions;Photons;Posture;Prefrontal Cortex;Process;Rattus;Resolution;response;Reversal Learning;Reverse engineering;Rewards;Running;Signal Transduction;Stimulant;Stimulus;Substance Use Disorder;Testing;Time;tool;Uncertainty;Work

PROJECT_TITLE: Cortico-Amygdalar Substrates of Adaptive Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The objective of this proposal is to understand systemic factors, with a focus on provider-patient interactions, that may contribute to the reduced access of Black and Hispanic patients to waitlisting and kidney transplantation. We will also examine how provider-related assessments of patients associate with outcomes following the onset of end-stage kidney disease.

PI_NAMEs: DUDLEY, R. ADAMS ;JOHANSEN, KIRSTEN L.;KU, ELAINE  (contact);ZHANG, RUI

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: access disparities;Accounting;Address;Adult;Attitude;Behavior;Belief;Black race;Blood;California;Cessation of life;Characteristics;Chronic Kidney Failure;Clinic;Clinical;Complex;Creatinine;Data;Dialysis procedure;Education;Electronic Health Record;Eligibility Determination;End stage renal failure;ethnic disparity;Ethnic Origin;Evaluation;follow-up;Frequencies;Future;Geography;Goals;graft failure;Healthcare;Healthcare Systems;High Prevalence;high risk;Hispanic;Hospitalization;impression;improved;Individual;Inequity;Information Systems;interest;Intervention;Justice;Kidney;Kidney Transplantation;Language;Life;Link;Maryland;Mediating;Mediator;Medical;Minnesota;Modality;Modification;Monitor;mortality;mortality risk;Nephrology;Not Hispanic or Latino;novel strategies;Onset of illness;Organ;Organ Transplantation;Outcome;outcome prediction;Pathway interactions;Patient-Focused Outcomes;Patients;Perception;PF4 Gene;Play;Policies;post-transplant;Process;Provider;Publishing;Quality of life;Race;racial disparity;racial diversity;Role;Serum;socioeconomics;Source;System;Texas;therapy design;transplant centers;Transplant Recipients;Transplantation;Universities;Waiting Lists

PROJECT_TITLE: Racial disparities in access to kidney transplantation

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Neurons depend on the transport of mRNA down axons and dendrites so that the mRNA can be translated into proteins locally. We uncovered a mechanism by which mRNA travels on mitochondria by binding to a protein called synaptojanin2. We now ask what species of mRNA use this method of transportation and how important the mechanism is for the health of neurons, synapses, and neuronal mitochondria.

PI_NAMEs: SCHWARZ, THOMAS L. (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;aged;Axon;Axonal Transport;Binding;Binding Proteins;Biological;Carrier Proteins;Catalogs;Cells;Data;Dendrites;Distal;Distant;Energy Supply;Funding;Health;human induced pluripotent stem cells;induced pluripotent stem cell;Inherited;Inositol;knock-down;Lipids;Maintenance;Mediating;Messenger RNA;Metabolism;Methods;Mitochondria;mitochondrial messenger RNA;Mitochondrial Proteins;Morphology;Mus;Mutant Strains Mice;Mutate;Mutation;neuronal cell body;neuronal survival;neuronal transport;Neurons;Outer Mitochondrial Membrane;Parkin;Parkinson Disease;Pathway interactions;Phosphoric Monoester Hydrolases;PINK1 gene;preservation;presynaptic;Presynaptic Terminals;prevent;Protein Biosynthesis;protein degradation;Proteins;Proton-Translocating ATPases;respiratory;RNA Binding;RNA Recognition Motif;Role;stressor;Synapses;Synaptosomes;SYNJ1 gene;System;Testing;Transcript;transcriptome;Translating;Translations;Transportation;Travel;Work

PROJECT_TITLE: Axonal Transport of mRNA for Mitochondrial Proteins

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]