NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: CHAMPAIGN

ORG_NAME: GLUCOSENTIENT, INC.

PHR: Project Narrative  Tuberculosis represents a significant healthcare burden especially for developing countries and today’s anti- TB treatment can effectively cure TB if it is monitored properly. Unfortunately, for countries with most of the TB burden, they do not have the resources to reach the maximum effectiveness the current anti-TB drugs can offer, including the ability to assess the drug exposure by monitoring their blood levels. For this Phase I project, we are going to demonstrate the feasibility of an anti-drug level monitoring system that is affordable and convenient to use by using existing blood glucose meter platform.

PI_NAMEs: LAN, TIAN  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: absorption;Affect;Antitubercular Agents;Area;assay development;bactericide;Biological;Biological Assay;Biological Markers;Blood;Blood Glucose;Blood specimen;Calibration;Cessation of life;Clinical;Clinical Trials;co-infection;Communicable Diseases;comorbidity;Consumption;cost;Country;data communication;design;detection limit;Developing Countries;Development;Device or Instrument Development;Devices;Diabetes Mellitus;Diagnostic tests;dietary;dosage;Drops;Drug Exposure;Drug Kinetics;Drug Monitoring;Drug resistance;drug resistance development;Drug usage;Effectiveness;Ensure;Epidemic;Ethambutol;Event;extensive drug resistance;Extreme drug resistant tuberculosis;Foundations;glucose monitor;healthcare burden;High Pressure Liquid Chromatography;HIV;Human Resources;Immunoassay;Immunosuppressive Agents;improved;Individual;Infrastructure;Ingestion;instrument;isoniazid;Laboratories;large scale production;Maintenance;Malabsorption Syndromes;manufacturing scale-up;Mass Fragmentography;Measurement;Measures;Medical;meter;Methods;Microfluidics;Monitor;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;operation;Outcome;Performance;Persons;Pharmaceutical Preparations;Phase;pill;point of care;Property;prototype;Pyrazinamide;Regimen;Renal function;research and development;Resources;response;Rifampin;Risk;Sampling;Serum;Small Business Innovation Research Grant;success;System;Techniques;Technology;Testing;Therapeutic;Time;Training;Treatment Failure;Treatment outcome;treatment program;treatment risk;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;Validation;Variant;Whole Blood

PROJECT_TITLE: Improving the effectiveness of anti-tuberculosis drugs by developing a point-of-care therapeutic drug monitoring system for areas with limited medical resources

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (13)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: BURLINGAME

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: AETON THERAPEUTICS, INC.

ORG_STATE: CA

PHR: Narrative Accumulation of acetyl-tau (ac-tau) impairs synaptic plasticity and spatial memory, appearing in the brains of Alzheimer’s disease (AD) patients at the earliest Braak stages prior to p-tau and is not detectable in the healthy brain. Ac-tau is a compelling therapeutic target for monoclonal antibody (mAb) treatment of tauopathy in AD, since ac-tau is a highly pathogenic tau modification that impairs tau homeostasis and induces tau mislocalization and synaptic toxicity. Aeton Therapeutics is developing a humanized anti-acetyl-tauK174 mAb to treat tauopathy and tau-mediated neuroinflammation in AD.

PI_NAMEs: GAN, LI ;SINHA, ANJANA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Acetylation;Acute;Aducanumab;Adult;Age;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloid;Amyloid beta-Protein;Antibodies;antibody engineering;Antibody Therapy;Atrophic;Behavior;Binding;Biochemical;Biochemistry;Biological Assay;Brain;caregiving;Caring;Cause of Death;Cells;Cerebrospinal Fluid;Cerebrum;Characteristics;Chronic;clinical translation;Coculture Techniques;Cognition;Cognitive deficits;Collaborations;comparative efficacy;cytokine;Deposition;Development;Direct Costs;Disease;Dose;Drug Kinetics;Drug Targeting;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy study;Enzyme-Linked Immunosorbent Assay;Epitopes;Evaluation;FDA approved;Future;glial activation;Head;head-to-head comparison;hippocampal atrophy;Hippocampus;Homeostasis;Human;human old age (65+);human tissue;Hybridomas;hyperphosphorylated tau;immunodeficiency;Immunotherapy;Impairment;improved;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Inflammatory;inflammatory marker;Intravenous;Label;Laboratories;Learning;Licensing;Measures;Mediating;medical schools;Medicare;Memory;Microglia;Modeling;Modification;Monoclonal Antibodies;mouse model;murine monoclonal antibody;Mus;Neurofibrillary Tangles;neuroinflammation;Neurons;Organoids;Pathogenesis;Peptides;Pharmacodynamics;Phase;Plasma;Population;prevent;programs;Proteins;Quality of life;Recombinants;Research Contracts;Role;Safety;Senile Plaques;Small Business Innovation Research Grant;spatial memory;success;Synapses;Synaptic plasticity;System;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic target;Toxic effect;transcriptome sequencing;United States;Universities;Washington;Western Blotting;Work

PROJECT_TITLE: Acetylated Tau Immunotherapy for Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Macrophage stress signaling pathways underlie innate immune responses to bacterial infection. The molecular stress components that amplify mechanisms of inflammation and host defense are poorly understood. Our studies will identify how macrophage stress signals shape innate immunity to infectious agents that cause severe diseases like typhoid fever.

PI_NAMEs: O'RIORDAN, MARY  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Amino Acids;antimicrobial;Antimicrobial Resistance;Autophagocytosis;Bacterial Infections;biological adaptation to stress;Bone Marrow;burden of illness;Cell Line;Cell Physiology;Cells;Cellular biology;Cellular Stress;chronic infection;Communicable Diseases;Curiosities;cytokine;Data;Defect;Development;Disease;Environment;Essential Amino Acids;Eukaryotic Initiation Factors;experimental study;Foundations;FRAP1 gene;Functional disorder;General Practitioners;Goals;Host Defense;Human;Immune;Incidence;Infection;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Lead;Macrophage;Mediating;Mediator;Metabolic;Metabolism;Modeling;Molecular;Mus;Natural Immunity;Output;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phosphorylation;Phosphotransferases;Positioning Attribute;Predisposition;Process;Production;Proteins;quantitative imaging;Reporting;response;Ribosomes;Salmonella enterica;Salmonella infections;Salmonella typhi;Salmonella typhimurium;sensor;Shapes;Signal Pathway;Signal Transduction;small hairpin RNA;Stress;System;Testing;Therapeutic;Time;Transcript;transcription factor;Translations;Typhoid Fever

PROJECT_TITLE: Engagement of the macrophage integrated stress response in Salmonella infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Urologic Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: NANOPATHDX, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Urinary Tract Infections (UTIs) have an annual prevalence of over 11% of the US population with 15% - 20% of cases being resistant to first-line antibiotic therapy. Despite the severity and prevalence of UTIs, the existing culture-based standard-of-care takes several days to return a result, commonly resulting in empiric treatment of UTIs, and categorizing UTIs as one of the largest contributors to antibiotic resistance. Our technology is a point- of-care diagnostic platform that can identify UTI-causing pathogens and key genetic markers of antibiotic resistance from a patient urine sample in 15 minutes, enabling immediate administration of targeted of antibiotic therapy. .

PI_NAMEs: BURKLUND, ALISON  (contact);TADIMETY, AMOGHA

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Antibiotic Resistance;Antibiotic Therapy;Antimicrobial Resistance;assay development;Bacteremia;Bacterial Infections;Biological Assay;candidate validation;Clinical;Clinical Research;Clinical Sensitivity;clinically significant;Collaborations;Color;commercialization;cost;Coupled;cross reactivity;Cytolysis;Data;design;Detection;detection limit;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic platform;diagnostic technologies;Doctor of Philosophy;Elderly;Engineering;Ensure;Environment;experience;experimental study;Foundations;Genetic;Genetic Markers;Healthcare;Hospitals;Infection;innovation;instrument;interest;Life;manufacture;Methods;microbial;Molecular;molecular diagnostics;multiplex assay;nanosensors;Nucleic Acid Binding;Nucleic Acids;Organism;Outcome;Output;Pain;pathogen;Patients;Performance;Periprosthetic joint infection;Phase;point of care;point-of-care diagnostics;Population;Positioning Attribute;Preparation;Prevalence;rational design;Reporting;Reproducibility;Research;research clinical testing;Research Personnel;Resistance;resistance gene;Respiratory Tract Infections;Risk;Sampling;Sensitivity and Specificity;Sepsis;Series;Severities;Software Tools;Specificity;standard of care;Technology;Testing;Time;tool;Urinary tract infection;Urine;Validation;Veterans;Waste Management;Woman;Work

PROJECT_TITLE: Multiplexed Assay for Point-of-Care UTI Diagnosis (ID/AMR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TUCSON

ORG_NAME: LYCHEE BIOSCIENCE LLC

ORG_STATE: AZ

PHR: Project Narrative: The currently ongoing pandemic of coronavirus disease-2019 (COVID-19) is posing a severe infectious threat to human population across the globe, with more than 6.8 million deaths occur due to SARS-CoV-2 since its emergence in 2019 in Wuhan. Since many viruses have pandemic potential, broad-spectrum antivirals are urgently needed. Our proposed drug discovery research is of great potential in creating new broad-spectrum therapeutic agents to combat these disastrous viral infections.

PI_NAMEs: LI, HONGMIN  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Adaptor Signaling Protein;Alpha Virus;analog;Animal Model;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;betacoronavirus;Binding;Binding Sites;Biochemical;Biological Assay;candidate validation;Canis familiaris;Cell-Mediated Cytolysis;Cellular Assay;Cessation of life;Chemicals;China;Clinical;cofactor;combat;Common Cold;companion animal;Complex;Coronavirus;COVID-19;COVID-19 outbreak;COVID-19 pandemic;cross-species transmission;design;Development;Disease;Disease Outbreaks;drug candidate;drug development;drug discovery;Drug Kinetics;drug-like compound;Ebola virus;Effectiveness;Enzyme Inhibitor Drugs;Enzymes;FDA approved;Filovirus;Flavivirus;Fluorescence;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;follow-up;Funding;future outbreak;future pandemic;Genetic Materials;Healthcare;Henipavirus;high throughput screening;Human;Immune;Immune system;in vivo;Infection;influenzavirus;inhibitor;innovation;interest;Investigational Therapies;Knowledge;Label;Lead;Learning;Libraries;Medicine;Methylation;Methyltransferase;Microcephaly;Middle East Respiratory Syndrome Coronavirus;molnupiravir;mortality;mouse model;nirmatrelvir;Nonstructural Protein;novel;novel coronavirus;novel therapeutics;pandemic disease;pandemic potential;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Population;Positioning Attribute;Poxviridae;Prevention;previous outbreak;Property;Prophylactic treatment;Public Health;rational design;remdesivir;Research;Resources;Ribose;RNA;RNA Caps;S-Adenosylhomocysteine;S-Adenosylmethionine;SARS coronavirus;SARS-CoV-2 genome;SARS-CoV-2 infection;screening;Severe Acute Respiratory Syndrome;small molecule;small molecule inhibitor;Structure;targeted treatment;Testing;Therapeutic;Therapeutic Agents;tool;Vaccination;vaccine hesitancy;Vaccines;Variant;Viral;Viral Genome;Viral Nonstructural Proteins;Viral Physiology;viral RNA;Virulence;Virus;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Development of Inhibitors Against SARS CoV-2 NSP16 Methyltransferase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  Clostridioides difficile infection is responsible for thousands of deaths each year, and current antibiotic treatment is often ineffective resulting in a high rate of recurrent infections. These studies will determine the mechanism by which IFN-λ facilitates protection against C. difficile infection while uncovering a novel role for IFN-λ in the immune response against an enteric bacterial pathogen. A better understanding of how IFN-λ signaling contributes to protection in our model will aid future studies in developing life-saving treatments against infection with C. difficile as well as other enteric pathogens.

PI_NAMEs: MEARS, KEVIN STANTON (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Activities of Daily Living;Agonist;alternative treatment;Antibiotic Therapy;Antibiotics;antiviral immunity;Bacteria;Blocking Antibodies;Bone Marrow;Bone Marrow Cells;Cause of Death;Cell Death;Cell Lineage;Cell Separation;cell type;Cells;Cessation of life;Chimera organism;Clostridium difficile;Colitis;cytokine;Cytoprotection;Data;Disease;Enteral;enteric pathogen;Epithelial Cells;Epithelium;experimental study;Flow Cytometry;Future;gastrointestinal infection;Harvest;healing;Hospitals;Immune;Immune response;Individual;Infection;Inflammatory;Interferon Type II;Interferons;intestinal barrier;intestinal epithelium;Intestines;Knockout Mice;Large Intestine;LGR5 gene;Life;Measures;Mediating;Modeling;mortality;Mucous Membrane;Mus;novel;Oral;Oral Administration;Organoids;Pathogenesis;pathogenic bacteria;Pathway interactions;Proliferating;Proliferation Marker;protective effect;Public Health;Radiation;radioresistant;receptor;receptor expression;recurrent infection;repaired;Reporter;Role;Severities;Severity of illness;Signal Transduction;Stains;STAT1 gene;stem cell function;stem cell proliferation;stem cells;Testing;Therapeutic;therapeutic development;TLR7 gene;Toxin;Transplantation;treatment comparison;United States;Up-Regulation;Vancomycin;Viral;Water;Work

PROJECT_TITLE: Investigating the role of interferon lambda in protection against severe Clostridioides difficile infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative: Septins contribute to the development and maintenance for nearly every major organ system in humans. Membrane association is a critical step in septin function, but how septins are localized to different regions of the plasma membrane is not well understood. Discovery of the fundamental mechanisms driving septin assembly and function is essential to understand how septin sequence and expression changes lead to neurodegenerative diseases, cancer, and cardiomyopathy.

PI_NAMEs: CURTIS, BRANDY NICOLE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affinity;Amino Acids;Automobile Driving;base;Binding;Binding Sites;Biological Assay;Body System;C-terminal;Cardiomyopathies;Cell membrane;Cells;Cellular Membrane;Charge;Complement;Complex;Cryoelectron Microscopy;Cytokinesis;Defect;Dendritic Spines;design;Development;Dyes;Electron Microscopy;Filament;flexibility;Fluorescence Microscopy;Goals;Growth;Human;Hydrophobicity;in silico;In Vitro;in vivo;Length;Lipid Bilayers;Lipid Binding;Lipids;Liposomes;Maintenance;Malignant Neoplasms;Maps;Measures;Membrane;Membrane Lipids;meter;Molds;Molecular;molecular dynamics;molecular scale;Monitor;Mothers;mutant;nanodisk;nanometer;Neck;Neurodegenerative Disorders;Neurons;Outcome;particle;Phosphatidylinositols;polarized cell;preference;Process;Property;Proteins;Recombinants;reconstitution;Rod;Role;scaffold;self assembly;Shapes;Side;Signal Transduction;Site-Directed Mutagenesis;stoichiometry;Structure;Time;trafficking;Tube;Viral;Work;Yeasts

PROJECT_TITLE: How septin-membrane interactions direct septin assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: SONARA HEALTH INC

ORG_STATE: TX

PHR: Narrative - Methadone, an opioid agonist therapy, is the most effective treatment for severe opioid use disorder (OUD), and opioid treatment programs (OTPs) are the only medical settings allowed to administer this treatment. A March 2022 review encouraged regulatory revision to promote patient-centered care and facilitate access to take-home methadone; however, in order to safely and effectively implement take-homes, OTPs need evidence that methadone is used as directed and not diverted. This project will advance the Sonara platform, a HIPAA- compliant web-application that features integrated video dosing recording of patients drinking the take-home dose, and a tamper-evident seal that inhibits diversion attempts.

PI_NAMEs: DENNIS, MICHAEL L.;GILES, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Acceleration;Address;Adoption;American Indians;analog;Award;Black race;care costs;Caring;Cessation of life;Clinic;Clinical;clinical decision-making;Commuting;cost;Cost Analysis;Cost Savings;Counseling;COVID-19 pandemic;craving;Data;Data Collection;design;Dose;Dreams;drinking;Drug abuse;Drug Monitoring;Drug Use Disorder;Education;effective therapy;Electronic Health Record;Epidemic;Fentanyl;fentanyl use;Health;Health Insurance Portability and Accountability Act;health related quality of life;Home;illicit opioid;improved;Income;Individual;innovation;Interview;manufacture;Marketing;Measurement;Measures;Medicaid;Medical;Medical Care Costs;Methadone;methadone treatment;multiple drug use;Names;Opioid;opioid agonist therapy;opioid overdose;opioid treatment program;opioid use;opioid use disorder;opioid withdrawal;Overdose;Participant;Patient Monitoring;Patient Recruitments;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phase;phase 2 testing;Positioning Attribute;primary outcome;programs;Randomized;Regulation;Relaxation;Reporting;return to use;Risk;satisfaction;Schedule;seal;service programs;Services;Small Business Innovation Research Grant;Spanish;standard of care;Surveys;Testing;Time;tool;Toxicology;Transportation;Treatment Cost;treatment planning;United States;United States Substance Abuse and Mental Health Services Administration;Update;Urine;usability;Visual;web app

PROJECT_TITLE: Remote Observed Methadone Evaluation Phase II (ROME II): Retention and Costs of Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Genetic defects in the gene KCNQ2 can result in severe epilepsy affecting infants and children, but there are currently no specific therapies that target this gene. In this proposal, we are focusing on a specific element in the gene called an upstream open reading frame (uORF) that we discovered impairs optimal KCNQ2 translation into protein. Our work will determine if removing or blocking this uORF, possibly with a new class of drugs called antisense oligonucleotides, can boost levels of KCNQ2 protein in neurons as a potential strategy to overcome the predisposition to seizures and epilepsy caused by genetic defects in this gene.

PI_NAMEs: HUEY, DALTON JUN-DA (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 5' Untranslated Regions;Action Potentials;Acylation;Affect;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Attenuated;Binding;Biological Assay;Biology;Brain;candidate identification;Cell Line;Cells;Chemicals;Child;Complex;CRISPR/Cas technology;Cultured Cells;design;Development;Disease;Electrophysiology (science);Elements;Epilepsy;epileptic encephalopathies;Evaluation;experimental study;FDA approved;gene product;gene-targeted therapy;Genes;Genetic;genome editing;human induced pluripotent stem cells;Hydroxyl Radical;Impairment;induced pluripotent stem cell;Infant;Initiator Codon;insight;Intervention;Learning;loss of function;loss of function mutation;Loss of Heterozygosity;Marketing;Measures;Messenger RNA;Methods;Modeling;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neuroglia;Neuronal Differentiation;Neurons;novel drug class;Nucleotides;Open Reading Frames;overexpression;patch clamp;Pathogenicity;Pharmaceutical Preparations;Physiological;Predisposition;Primer Extension;Production;Property;Proteins;Reading Frames;Reporter Genes;ribosome profiling;Ribosomes;Seizures;Series;small molecule;Structure;System;targeted treatment;Terminator Codon;Therapeutic;therapeutic target;Transcript;Translation Initiation;Translations;Variant;Voltage-Gated Potassium Channel;Western Blotting;Work

PROJECT_TITLE: Exploiting KCNQ2 upstream open reading frames for therapeutic opportunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE The aim of this study is to identify novel circulating lipids associated with the risks of Alzheimer’s disease, dementia and cognitive decline. The research is conducted in the Cardiovascular Health Study, a cohort of older adults as well as using postmortem, well phenotyped brain samples from patients across the spectrum from normal to diagnosed Alzheimer’s disease. This research, which takes advantage of a novel technology to measure up to 1300 lipidomics species, will provide new targets for future interventions to reduce risks of dementia and cognitive decline.

PI_NAMEs: ARKING, DAN E (contact);LEMAITRE, ROZENN ;TRONCOSO, JUAN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acids;Adult;African ancestry;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Autopsy;Brain;brain research;cardiovascular health;Cells;Characteristics;Cognition;cohort;Cohort Studies;Dementia;dementia risk;Deposition;Dietary Factors;Docosahexaenoic Acids;Eicosapentaenoic Acid;European ancestry;Fatty Acids;Future;Health Transition;human old age (65+);Impaired cognition;insight;Intervention;lipid biosynthesis;lipidomics;Lipids;Measures;men;Methods;mild cognitive impairment;modifiable risk;Nerve Degeneration;new technology;novel;older adult;Omega-3 Fatty Acids;Outcome;Palmitic Acids;palmitoleic acid;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physical activity;Plasma;prevent;Prevention;prospective;Prospective cohort;Reporting;Research;Resources;Risk;Risk Factors;Risk Reduction;Sampling;Saturated Fatty Acids;Senile Plaques;societal costs;Specimen;tau Proteins;Technology;Tobacco use;Universities;Woman

PROJECT_TITLE: Circulating and Brain Lipidomics, Cognition and Dementia

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative This supplement proposes a two-year research and career development plan that allows Dr. Bah to work alongside mentors, assist on the parent grant deliverables, and conduct his own study aims that are building off of the parent study, “Social and Biological Mechanisms Driving the Intergenerational Impact of War on Child Mental Health: Implications for Developing Family-Based Interventions”, R01 MH128928-01. The aims of the proposed supplement are to explore Sierra Leonean definitions, perceptions, and behaviors that depict positive parental engagement, how they differ between mothers and fathers, and respiratory sinus arrhythmia (RSA) assessment of dyadic interactions. To guide this study, we will explore the social interaction learning (SIL) model that has been used to guide studies on parent-child interactions in a post-conflict setting 11.

PI_NAMEs: BETANCOURT, THERESA STICHICK (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Adolescent;Affect;aged;Automobile Driving;Behavior;Biological;career development;Child;Child Development;Child Health;Child Mental Health;Child Rearing;Cognition;Communities;Complex;Conflict (Psychology);Country;Data;Development;Development Plans;deviant;Disease Outbreaks;Distress;dyadic interaction;Ebola;Ecology;Economics;Ecosystem;Emotions;experience;Family;Family dynamics;family support;Fathers;Female;Focus Groups;Gender;improved;Individual;informant;instrument;intergenerational;Intervention;Interview;Learning;Link;Long-Term Effects;Longitudinal Studies;low and middle-income countries;male;Mental Health;Mental Health Services;Mentors;Methods;Modeling;modifiable risk;Mothers;multilevel analysis;Nature;Negative Reinforcements;neglect;Neighborhoods;offspring;Outcome;parent grant;Parent-Child Relations;parental role;Parents;Patient Self-Report;Pattern;Perception;Personal Satisfaction;physical conditioning;Physiological;Population;Prevention;protective factors;Research;research and development;Resources;respiratory;response;Risk;Risk Factors;Rural;Sampling;Screening procedure;Self Efficacy;Shapes;Sierra Leone;Sinus Arrhythmia;social;Social Functioning;Social Interaction;stress reactivity;stressor;support tools;Surveys;Techniques;theories;Time;Trauma;trauma exposure;traumatic event;War;Work;Youth

PROJECT_TITLE: Social and Biological Mechanisms Driving the Intergenerational Impact of War on Child Mental Health: Implications for Developing Family Based Intervention


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hearing Loss;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HANOVER

ORG_NAME: CREARE, LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE One in eight people in the United States aged 12 years or older has hearing loss in both ears, with varied root causes. This project will result in a new research platform that is completely open and accessible to anyone to conduct research studies (designs and source code will be openly available on the web). It will also allow researchers to store their data in an online hub that can be accessed by anyone to use and review the data. The ultimate objective is to spur innovation in the development of treatments and interventions for hearing loss.

PI_NAMEs: CLAVIER, ODILE H (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: 12 year old;Academia;Acoustics;American;Animal Model;Animals;Auditory;Cellular Phone;Clinical;commercialization;Communities;computer science;Computer software;cost;Data;Data Analyses;data repository;Data Science;Data Set;data sharing;design;Development;Device Designs;Devices;Diagnostic;Ear;ear muscle;Educational workshop;Engineering;Enrollment;Ensure;Evaluation;Evoked Potentials;Goals;Government;handheld mobile device;Hearing;hearing impairment;hearing range;Hearing Tests;Human;human subject;improved;Incentives;Indiana;Industry;innovation;Internet;Intervention;Laboratories;Libraries;Measurement;Measures;Meta-Analysis;middle ear;multidisciplinary;multiple datasets;open data;open source;otoacoustic emission;Otolaryngology;Persons;Population;Protocols documentation;Publishing;Reflex action;repository;Reproducibility;Research;Research Personnel;research study;Resources;Science;Semantics;Societies;Software Design;Source Code;speech recognition;Standardization;symposium;System;Tablets;Testing;therapy development;tool;Training;Transducers;United States;Universities;uptake;user-friendly;Work

PROJECT_TITLE: Open Source Hearing Assessment System for Open Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Diabetes affects over an estimated 422 million individuals globally and nearly 1 in 10 Americans, yet the causes of diabetes are still poorly understood. Our mission is to assess how genetic changes can alter the ability of insulin-producing pancreatic β-cells to respond to inflammatory stress, ultimately resulting in β-cell damage and dysregulated blood sugar. We hope that our findings will provide new insights into the source of diabetes development.

PI_NAMEs: HENRY, BELLE ALEXIS (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Affect;American;Applications Grants;autoimmune pathogenesis;Autophagosome;Beta Cell;Biochemical;Blood Glucose;career;Cell Death;cell injury;Cell Physiology;Cell Survival;cell type;Cessation of life;Clinical;Crohn's disease;cytokine;Data;Dependence;Development;Diabetes Mellitus;Doctor of Philosophy;Educational Curriculum;Epidemic;Epidemiology;Exposure to;Failure;Functional disorder;Future;gain of function mutation;Genetic;Genetic Transcription;glycemic control;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Human;Immune system;Immunology;Immunomodulators;Impairment;improved;in vivo;Individual;Induction of Apoptosis;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;insight;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin-1 beta;islet;knock-down;Knockout Mice;laboratory experience;Link;LRRK2 gene;Maintenance;Mediating;Membrane;Mentors;Mentorship;Michigan;Mission;Mitochondria;mitochondrial autophagy;Modeling;Molecular;mouse model;multidisciplinary;Mus;Mutation;novel;Pancreas;Parkin;Parkinson Disease;Pathway interactions;Peripheral;Persons;pharmacologic;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Prevalence;prevent;Prevention;Productivity;programs;protective effect;Quality Control;rab GTP-Binding Proteins;recruit;Regulation;response;Risk;Role;small hairpin RNA;Sorting;Source;Stimulus;Stress;stressor;Structure of beta Cell of islet;targeted treatment;Testing;therapeutic candidate;therapeutic target;TNF gene;Toxic effect;trafficking;Training;Training Programs;transcriptomics;Universities;Up-Regulation;Work;Writing

PROJECT_TITLE: The role of LRRK2 in pancreatic beta cell responses to inflammatory damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


NIH_SPENDING_CATS: Aging;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WILMINGTON

ORG_NAME: RHINO THERAPEUTICS INC

ORG_STATE: DE

PHR: PROJECT NARRATIVE Diminishment or distortion in the sense of smell (olfaction) with age is common, an unmet health care need, and compromises quality of life, nutritional status, and personal safety. The olfactory stem cells and the sensory neurons in the nose disappear, and the population of dormant stem cells, called horizontal basal cells (HBCs), that are held in reserve fail to activate, despite the pathological changes in the tissue. Ultimately, we seek to synthetically activate the HBCs by developing and treating with an siRNA drug as the first approved therapy for treating age-related smell loss; our goal is closely aligned with one of the mission areas of the National Institute on Deafness and Other Communication Disorders.

PI_NAMEs: SCHWOB, JAMES E.;WYNNE, GRAHAM MICHAEL (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acute;Adult;Afferent Neurons;Age;age related;Air;airway epithelium;Anosmia;Area;Basal Cell;Birth;cell type;Cells;Clinical Trials;Clip;commercialization;Consensus;Data;Death Rate;Development;Disease;Dorsal;Dose;Drug Design;Drug Kinetics;Elderly;Engraftment;Epithelial Cells;epithelial injury;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;Evaluation;exhaust;exhaustion;Exposure to;Formulation;frailty;Functional disorder;Future;Genes;Goals;Health;Healthcare;Heritability;Human;Immunocompromised Host;immunosuppressed;In Situ;In Vitro;in vivo;Incubated;Infusion procedures;Injury;Keratin;knock-down;Knock-out;Legal patent;life span;medical schools;member;Metaplasia;Mission;Modification;Molecular;Monitor;mouse model;Mus;Nasal cavity;National Institute on Deafness and Other Communication Disorders;Natural regeneration;nerve stem cell;neuroepithelium;neurogenesis;Neuroglia;Neurons;Nose;Nude Rats;Nutritional;Nutritional status;Olfactory dysfunction;Olfactory Epithelium;olfactory sensory neurons;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Population;pre-clinical;Prevalence;Production;Proliferating;Proteins;Quality of life;Rattus;regenerative;Regimen;Rejuvenation;Research;Reserve Stem Cell;respiratory;Rights;Risk;RNA Interference;RNA Interference Therapy;Safety;selective expression;Small Business Technology Transfer Research;Small Interfering RNA;Smell Perception;stem;stem cell function;stem cell population;stem cells;Therapeutic;Thinness;Tissues;Toxic effect;Toxicant exposure;transcription factor;Transgenic Organisms;Universities;Well in self;Wit;Xenograft procedure

PROJECT_TITLE: Evaluation of siRNA based drugs as pro-regenerative disease-modifying therapeutics for age-related olfactory loss


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Boston

ORG_NAME: QUANTUM SIMULATION TECHNOLOGIES, INC.

PHR: Project Narrative Computational chemistry augments the vast majority of modern drug discovery efforts by providing crucial insight into drug binding, and relative binding free energy calculations have had a major impact by expediting the hit-to-lead phase of discovery. For small molecule drug discovery, the success of computational lead optimization is well documented, and peptide drug discovery is situated to similarly benefit from such analyses following the development of reliable computational approaches. We propose to develop a novel machine learning-based peptide simulation model that circumvents the major barriers for accurate binding free energy predictions by combining the efficiency of classical models with the accuracy and flexibility of quantum mechanics.

PI_NAMEs: WHITE, ALEC  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Address;Affinity;algorithm development;aqueous;Area;Behavior;Binding;Binding Proteins;Charge;Chemicals;computational chemistry;computational suite;Computer software;computerized tools;cost;cost effective;Data;Databases;density;Development;Drug Design;drug development;drug discovery;Drug Kinetics;Drug Screening;Environment;expectation;flexibility;Free Energy;Half-Life;Healthcare;in silico;innovation;insight;Lead;lead optimization;Life;Literature;Machine Learning;machine learning model;machine learning prediction;Marketing;mechanical energy;mechanical force;Metabolic;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;molecular dynamics;novel;Peptide Conformation;peptide drug;Peptides;Pharmaceutical Preparations;Phase;predictive modeling;Property;protein complex;Proteins;quantum;Quantum Mechanics;Research;Sampling;simulation;small molecule;Solvents;Source;Specificity;success;Surface;Testing;theories;Therapeutic Index;tool;Training;Validation;virtual screening;Work

PROJECT_TITLE: Binding free energy predictions for peptide drugs: A novel machine learning-based peptide simulation model for high-throughput computational lead optimization with quantum mechanical accuracy.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


ADMINISTERING_IC: AT

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products;Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE The nicotinic acetylcholine receptors (nAChRs) are crucial membrane-bound receptors found throughout the central nervous system that have been implicated in a variety of disease states. High levels of similarity between nAChR subtypes, however, have limited their pharmacological utility, as few ligands that are both selective and potent have been identified. This proposed project investigates a series of alkaloids from Aristotelia chilensis, accessed through isolation and biomimetic synthesis, for their activity as subtype-selective nAChR antagonists, which will lay the foundation to develop new tools to improve the field’s understanding of the nAChRs.

PI_NAMEs: RUSALI, LISA ELIANA (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Adsorption;Affect;Alkaloids;alpha-bungarotoxin receptor;antagonist;Binding;Binding Sites;Biological;Biological Assay;Biomimetics;Cell Communication;Cells;Central Nervous System;Central Nervous System Diseases;channel blockers;Column Chromatography;countercurrent chromatography;Data;Development;Disease;Docking;drug development;Drug Kinetics;Ensure;Evaluation;Family;Foundations;Future;improved;in silico;Indole Alkaloids;innovation;insight;Investigation;Ion Channel Gating;Libraries;Ligand Binding;Ligands;Liquid substance;Measures;Membrane;meter;Methods;Minor;Modification;Monoterpenes;mutant;Natural Products;Nicotinic Receptors;novel;Pathologic;pharmacologic;Pharmacology;Phase;Play;Property;receptor;receptor binding;receptor function;Recovery;Research;Route;scaffold;Sequence Homology;Series;Signal Transduction;Solid;Testing;tool;Work

PROJECT_TITLE: Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Histone proteins are core genome organizers that are essential for regulating gene expression and chromatin structure, which are roles emphasized by an emerging class of rare pediatric neurodevelopmental disorders (NDDs) caused by germline missense mutations in replication-independent (RI) histone genes. Using an innovative approach that harnessed the power of large-scale databases, we predicted a subset of novel putative histone-encoding disease candidate genes most likely to cause disease when mutated, and subsequently identified a previously unpublished cohort of unrelated patients with a recurrent germline missense mutation in the RI histone MACROH2A1 (c.80G>A, p.R27Q) who presented to clinical attention with an NDD that shares a striking degree of phenotypic overlap with other mutant-RI histone-driven histonopathies. In this study, we will interrogate, for the first time, the fundamental features of MACROH2A1 in a human model of neurodevelopment and then quantify the resulting epigenetic dysregulation caused by this shared mutation, leading to evidence for a unifying model of heterozygous missense mutations in RI histones acting through a conserved pathogenic mechanism, which would provide the foundation for therapeutic development; and resulting in the advancement of the field of histone neurobiology, the benefits of which could extend to providing insights into common neurodegenerative pathologies, like Alzheimer’s Disease.

PI_NAMEs: LUBIN, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Address;Affect;Alzheimer like pathology;ATAC-seq;Attention;base editing;base editor;Binding;Biological Assay;Biology;Brain;Candidate Disease Gene;Cell Cycle;Cell Line;Cell Proliferation;cell type;Cells;Charge;Childhood;Childhood Glioma;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Co-Immunoprecipitations;cohort;Core Protein;Cytosine;Data;de novo mutation;Deposition;derepression;Detection;Development;Developmental Delay Disorders;differential expression;Disease;DNA;Dominant-Negative Mutation;Environment;Epigenetic Process;Exhibits;exome sequencing;Family;Fellowship;Foundations;gain of function;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Genotype-Tissue Expression Project;Germ Lines;Germ-Line Mutation;Heterozygote;Histone H3.3;Histones;Hot Spot;Human;human induced pluripotent stem cells;human model;Human Pathology;in vitro Model;Induced Mutation;innovation;insight;Intellectual functioning disability;Knowledge;large-scale database;Mass Spectrum Analysis;Measures;Methods;Missense Mutation;Modeling;mutant;Mutate;Mutation;Nerve Degeneration;nerve stem cell;neural;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurons;novel;Nuclear;Nucleosomes;palliative;Pathogenicity;Pathway interactions;patient population;Patients;Pediatric Hospitals;Pennsylvania;Phenotype;Philadelphia;Play;Population;Post-Translational Protein Processing;Process;Proteins;Proteomics;Publications;Radial;Recording of previous events;Recurrence;Refractory;Reproducibility;Research Personnel;Role;Sequence Homology;Somatic Mutation;Syndrome;System;Testing;therapeutic development;Time;Tissue Sample;Tissues;Training;transcriptome sequencing;transcriptomics;translational impact;Universities;Variant;Work;X Inactivation

PROJECT_TITLE: De novo mutations in replication-independent histone genes and an unexplored class of rare pediatric mendelian syndromes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: MARYSVILLE

ORG_NAME: LIFEBIO INC

ORG_STATE: OH

PHR: Project Narrative LifeBioTALK aims to address the emotional and psychosocial needs of a person with dementia (PWD) with pre-planned engaging content that may lessen loneliness and the impact of challenging behavior, thereby improving quality of life for PWD while reducing the stress of the caregiver. Commercial markets will include organizations reaching in-home dementia caregivers (health plans, home care) as well as long- term care, assisted living, and memory care.

PI_NAMEs: SANDERS, LISBETH  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Apple;Assisted Living Facilities;Back;Behavior;Behavioral Symptoms;care preference;Caregiver Burden;caregiver stress;Caregivers;Caring;Cartoons;Child;clay;Clinical Research;commercialization;Computer software;Confusion;Data;Data Collection;Data Reporting;Databases;Dementia;Dementia caregivers;Depressed mood;design;Development;Devices;digital;Drama;eligible participant;Emotional;Enrollment;experience;Eye Movements;Face;Feedback;Feeling;Female;Fishes;Floor;Frustration;Funding;Future;Geriatrics;Goals;health plan;Hispanic;Home;Human;human old age (65+);Image;imaging detection;improved;Learning;Life;Loneliness;Long-Term Care;Loudness;Managed Care;Marketing;memory care;Movement;Multimedia;Music;Narration;Participant;patient home care;Patient Self-Report;person centered;Persons;Phase;Play;prototype;Psyche structure;psychological symptom;psychosocial;Published Comment;Quality of life;Reaction;Residential Treatment;response;Secure;Small Business Innovation Research Grant;Smiling;Social isolation;Social support;Stress;stress reduction;System;Tablets;Technology;Testing;Time;Translating;tv watching;Universities;usability;Video Recording;Violence;Vision;wireless fidelity;Work

PROJECT_TITLE: LifeBioTALK: Digital Engagement with a Pre-Scripted Avatar for People with Alzheimer's Disease to Reduce Challenging Behaviors and Caregiver Burden

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Approximately 1.25 million Americans have Type 1 Diabetes, where the immune system targets insulin- producing b cells within the islets of Langerhans for destruction, and there is no cure as we do not know how to stop this immune-mediated attack. We have generated a novel mouse model in which the sialic acid transferase ST8Sia6 is expressed in b cells in NOD mice, which reduces the incidence of diabetes by 90%. The focus of this proposal is to examine the changes in the immune response which protect pancreatic b cells from immune-mediated attack in this model, and to determine if this improves efficacy of islet transplantation.

PI_NAMEs: SHAPIRO, VIRGINIA SMITH (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acids;Age;American;Autoimmune Diabetes;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;autoreactivity;B-Lymphocytes;Beta Cell;beta cell replacement;Binding;Blood Glucose;blood glucose regulation;Body part;cancer cell;CD8B1 gene;Cell surface;Cells;Chronic;Clinic;cytotoxic;Development;Diabetes Mellitus;diabetic;Diamond;Doxycycline;effector T cell;Environment;experimental study;Family;Female;Generations;Genes;Genetic study;Genetically Engineered Mouse;Growth;Health;Human;human embryonic stem cell;Immune;immune activation;immune function;Immune mediated destruction;Immune response;Immune system;Immunologics;Immunosuppression;Immunotherapy;improved;Inbred NOD Mice;Incidence;infection risk;Inflammation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;insulitis;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Kidney Diseases;Laboratories;Learning;Ligands;Macrophage;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;Myeloid Cells;neoplastic cell;Non obese;novel;overexpression;Pancreas;Patients;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Polysaccharides;Population;Prediabetes syndrome;prevent;Procedures;Protocols documentation;receptor;recruit;Regimen;Regulatory T-Lymphocyte;Replacement Therapy;Retinal Diseases;sialic acid binding Ig-like lectin;Sialic Acids;Sialyltransferases;Source;Structure of beta Cell of islet;Surface;synergism;systemic autoimmunity;T-Lymphocyte;Testing;Tissues;Transferase;Transgenes;Translating;Transplantation;Work

PROJECT_TITLE: Inhibition of autoimmune diabetes by ST8Sia6

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: Antibodies that block immune checkpoint receptors such as PD-L1 and PD-1 have impressive efficacies against an array of human cancers due to their ability to enhance anti-tumor T cell responses. Despite the observed clinical success of these immunotherapies, the interactions between PD-L1 and its binding partners that dictate its function in promoting immunity are still rather poorly understood. In this proposal, we uncover a novel regulatory mechanism by which PD-L1 and CD80 expressed on activated DCs dictate chemokine-driven migration during a type I immune response and downstream memory T cell responses.

PI_NAMEs: KANTHETI, UMA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Amino Acids;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Binding;Blocking Antibodies;CD28 gene;CD80 gene;Cell Communication;cell motility;Cell Surface Proteins;Cells;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint receptors;chemokine;chemokine receptor;Clinic;Clinical;Cross Presentation;Cytoplasmic Tail;Data;Defect;dendritic cell vaccination;Dendritic Cells;draining lymph node;Endothelium;exhaust;exhaustion;extracellular;Extracellular Domain;Family;Frequencies;Goals;Human;Image;immune checkpoint;Immune response;Immune system;Immunity;Immunotherapy;Impairment;Infection;Infectious Skin Diseases;Inflammatory Response;Innate Immune Response;Laboratories;Ligands;lymph nodes;Malignant Neoplasms;Mediating;Membrane Proteins;Memory;Mentors;migration;Mind;Modeling;mouse model;Mus;Mutant Strains Mice;Mutate;Mutation;new therapeutic target;novel;novel therapeutic intervention;Organ;pathogen;Pathogenicity;Patients;Peripheral;Phenotype;Play;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;Protein Family;protein protein interaction;Publishing;receptor;Receptor Signaling;Regulation;Residencies;Resolution;response;Role;Sentinel;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;success;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;tissue resident memory T cell;Tissues;trafficking;tumor;two photon microscopy;Vaccinia;Vaccinia virus;Viral Antigens;Virus Diseases;Work

PROJECT_TITLE: Programmed death ligand-1 interactions in the regulation of dendritic cell migration and T cell priming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products;Regenerative Medicine

ORG_CITY: Monrovia

ORG_NAME: INVIZYNE TECHNOLOGIES, INC.

PHR: Project Narrative – Invizyne Technologies, Inc Late-stage functionalization of drug molecules by adding methyl (or other alkyl) groups can greatly alter the pharmacological properties by orders of magnitude – the ‘magic methyl effect’ – yet are difficult to achieve chemically. Nature has evolved methyltransferase (MT) enzymes as powerful tools to add specific methyl groups to molecules and Inivzyne’s cell-free S-adenosylmethionine (SAM) regeneration system, SimpleSAM, exploits MTs and SAM regeneration for discovery and industrial production of methylated pharmaceutical chemicals. Completion of this Phase I SBIR focuses on the development of GlyCoSAM, a deployment-ready platform technology for enzyme- based biomanufacturing of methylated chemicals which can ultimately enable production of previously inaccessible pharma- and nutraceuticals via green chemistry.

PI_NAMEs: BRUECKNER, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: GlyCoSAM: Glycolysis coupled S-adenosyl methionine regeneration for cell-free methylation reactions


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Lung

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Group 2 innate lymphoid cells (ILC2) are an important driver of inflammation in allergen-exacerbated asthma, but the mechanisms that govern their activation and proliferation are poorly defined. I have used the Collaborative Cross recombinant inbred mouse panel to identify a 0.343 megabase quantitative trait locus (QTL) with 72 protein-coding genes associated with the number of lung ILC2, which is a function of their activation and proliferation in response to aeroallergen challenge. We hypothesize that CD22, a cell-surface receptor previously implicated in the inhibition of B cell proliferation, is the gene within the QTL that is responsible for driving this ILC2 phenotype, and we aim to define the ability of CD22 to inhibit ILC2 proliferation, and as a consequence, suppress innate type 2 inflammation.

PI_NAMEs: RUSZNAK, MARK  (contact)

PROJECT_TERMS: Acute;Adaptive Immune System;airborne allergen;airway epithelium;airway inflammation;Allergens;allergic airway inflammation;Allergic Disease;Allergic inflammation;Alternaria;Ambulatory Care;Antibodies;Antigen Receptors;Antigens;Asthma;asthma exacerbation;Automobile Driving;B Cell Proliferation;B-Lymphocytes;Blocking Antibodies;Candidate Disease Gene;CD22 gene;CD4 Positive T Lymphocytes;Cell Count;Cell Proliferation;Cell Surface Receptors;cell type;Cells;Cellular biology;Chronic Disease;Clinical;clinically relevant;Code;Complex;cytokine;Data;Direct Costs;Drug Targeting;environmental allergen;eosinophil;Epithelial Cells;Exhibits;experimental study;Family;FDA approved;fungus;Gene Deletion;Gene Targeting;Genes;Genetic study;Genetic Variation;Genome;Genotype;Goals;Haplotypes;Hospitalization;House mice;Human;human disease;Immune;Immune Targeting;in vivo;Inbred Mouse;Inbreeding;Inflammation;Inflammatory;Inflammatory Response;interest;Interleukin-13;Interleukin-5;Investigation;Knock-out;Knockout Mice;Knowledge;Link;Lung;Lymphoid Cell;Maps;Measures;Mediating;microbial;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mosaic;mouse genetics;Mouse Strains;Mus;new therapeutic target;novel;Pathogenesis;Pathogenicity;Peptide Hydrolases;Pharmaceutical Preparations;Phenotype;Play;Polygenic Traits;Process;Production;Proliferating;Proteins;pulmonary function;Quantitative Trait Loci;receptor;Receptor Inhibition;Recombinants;Reporting;Research;respiratory challenge;response;Role;sensitizing antigen;sialic acid binding Ig-like lectin;Signal Pathway;Signal Transduction;SNP array;success;Testing;The Jackson Laboratory;therapeutic target;TSLP gene;United States;Wild Type Mouse

PROJECT_TITLE: QTL mapping with Collaborative Cross mice defines genes that promote allergic airway inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE People with Down syndrome have a 75-90% lifetime risk for Alzheimer’s disease, however there is a large variability in the timing of AD pathology and symptomology. Cross-sectional evidence suggests that body mass index may be a risk factor related to Alzheimer’s disease outside the Down syndrome population; there is an urgent need for longitudinal studies that can determine the time-ordered nature of these associations within Down syndrome. The research specific aims of this F31 project will leverage existing longitudinal data (three cycles of data collection) to examine the effect of body mass index and weight change on imaging biomarkers of Alzheimer’s disease pathology (PET Aβ and tau PET), cognitive decline (episodic memory, executive functioning, motor planning and control, and dementia symptoms), and clinical Alzheimer’s disease status (cognitively stable, mild cognitive impairment, and Alzheimer’s disease) and explore whether inflammation (biomarkers of serum c-reactive protein, interleukins-6, interleukins-10, and tumor necrosis factor alpha) mediates these associations, in a large cohort of adults with Down syndrome.

PI_NAMEs: FLEMING, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Address;Adult;Age;Age of Onset;aged;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analytical method;Apolipoproteins;Biological;Biological Markers;Body mass index;Body Weight Changes;Body Weight decreased;C-reactive protein;career;Chromosome abnormality;Chronology;Clinical;Cognition;Cognitive;cognitive performance;cohort;comorbidity;Computer software;Cross Syndrome;Data;Data Collection;Dementia;Diabetes Mellitus;Diagnosis;Down's Syndrome;Educational workshop;Ensure;Epidemiology;Episodic memory;executive function;exercise program;Fellowship;Funding;Goals;Health;healthy aging;Hypertension;imaging biomarker;Impaired cognition;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Intellectual functioning disability;Interleukin-10;Interleukin-6;Intervention Trial;Karyotype;Knowledge;late life;Learning;life span;lifetime risk;Linear Models;Link;longitudinal dataset;Longitudinal Studies;Mediating;Mentors;Methods;middle age;mild cognitive impairment;Modeling;modifiable risk;Motor;multilevel analysis;Natural History;Nature;Nerve Degeneration;Neurofibrillary Tangles;Obesity;Overweight;Participant;Pathology;Persons;Physical activity;Population;Populations at Risk;Positron-Emission Tomography;Postdoctoral Fellow;Prevalence;prevent;Prevention program;Production;programs;Quality of life;Research;Research Personnel;Risk;Risk Factors;Role;Sample Size;Senile Plaques;Serum;Site;skills;social interventions;Social Policies;Symptoms;tau Proteins;Time;TNF gene;Training;United States;United States National Institutes of Health;virtual;Weight;Work

PROJECT_TITLE: Weight, inflammation, and Alzheimer's disease in Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


PHR: NARRATIVE The proposed experiments are aimed at understanding how different parts of the brain form in the correct place. Brain formation is sensitive to disruptions by a variety of factors (e.g., environmental toxins, infectious agents, and genetic conditions) that give rise to a range of neurodevelopmental disorders – ranging from motor control problems such as ataxia, to cognitive defects such as autism. The results from our experiments will begin explaining the basis of such disorders and will help inform studies aimed at treating them.

PI_NAMEs: SAGERSTROM, CHARLES G (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Anatomy;ATAC-seq;Ataxia;autism spectrum disorder;Automobile Driving;Brain;Cell Nucleus;cell type;Cells;Chromatin;Clinical Treatment;Cognitive deficits;combinatorial;Complement;Data;Deposition;Development;developmental neurobiology;Disease;Embryo;Embryonic Development;experimental study;Fibroblast Growth Factor;future implementation;Gene Expression;Gene Expression Profile;gene regulatory network;Genetic;Genetic Diseases;Genetic Transcription;Goals;hindbrain;Individual;Infectious Agent;Knowledge;Location;Modeling;Molecular;Molecular Analysis;Molecular Profiling;morphogens;motor control;mutant;nerve stem cell;neural;neural circuit;Neurodevelopmental Disorder;Neurons;neuroregulation;Population;Positioning Attribute;Primordium;Process;progenitor;programs;Regulatory Element;Repression;Resolution;response;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;stem cell fate specification;stem cell population;stem cells;Testing;Time;tool;Toxic Environmental Substances;transcription factor;transcriptome sequencing;Translational Activation;Tretinoin;Visual;Zebrafish

PROJECT_TITLE: Molecular Analysis of Hindbrain Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-T (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hematology;Human Genome;Infectious Diseases;Microbiome;Nutrition;Prevention;Sepsis

ORG_CITY: NORTH CHICAGO

ORG_NAME: COVIRA SURGICAL

PHR: NARRATIVE While millions of patients receive life-saving chemotherapy every year, their untoward effects on the gastrointestinal (GI) track can be severe enough to limit treatment, increase hospitalizations, and/or increase risk of death. While much attention has been paid to the development of newer and more effective agents, their GI toxicities remain problematic. Covira Surgical is developing a first-in-class agent to prevent chemotherapy- related gastrointestinal toxicities that limits direct epithelial damage, dysbiosis and lethal gut-derived bacteremia and sepsis.

PI_NAMEs: ALVERDY, JOHN C;HENNESSEY, PATRICK  (contact)

PROGRAM_OFFICER_NAME: LI, MELISSA WANLING

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Address;American;Anemia;Animals;Antibiotic Resistance;Antibiotics;Area;Attention;Bacteremia;Bacteria;Bacterial Infections;Bacterial Translocation;Blood;Cancer Patient;cancer therapy;Cecum;Cells;Cellular Structures;Cessation of life;chemotherapeutic agent;chemotherapy;Ciprofloxacin;Colon;Colorectal Cancer;Consumption;copolymer;Data;Death Rate;Development;Diarrhea;Diet;Disease Progression;drinking;drinking water;drug metabolism;dysbiosis;Edema;efficacy evaluation;efficacy testing;Endothelium;Epithelium;Exposure to;Fatality rate;Fatigue;Future;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;General Population;Goals;Growth;gut microbiome;gut microbiota;high-fat/low-fiber diet;Histology;Hospitalization;Human;ileum;Immune system;improved;improved outcome;Infection;Infiltration;Inflammatory;Injury;inorganic phosphate;intestinal injury;irinotecan;jejunum;Legal patent;Life;Liver;Marketing;Measures;Methotrexate;Microbe;microbiome;microbiome sequencing;Modeling;mortality;mortality risk;Mucins;Mucous Membrane;Mus;nephrotoxicity;novel;novel therapeutics;Operative Surgical Procedures;Oral;Oral Administration;pathogen;Pathology;Patients;Permeability;Phase;Phosphorylation;Play;Polyethylene Glycols;Predisposition;preservation;prevent;Proliferating;protective effect;Quality of life;resistant strain;Rodent;Sampling;Sepsis;Source;Spleen;stem cell function;stem cells;Submucosa;Surface;Therapeutic;Tight Junctions;Toxic effect;Treatment-related toxicity;tumor microenvironment;tumor progression;Ulcer;Villus;Water;Weight;western diet

PROJECT_TITLE: Preventing chemotherapy-related toxicities and infections with a novel phosphorylated triblock copolymer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (10)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: ENTERX BIOSCIENCES, INC.

ORG_STATE: OR

PHR: Project Narrative There are many inherited genetic diseases that affect the retina, causing vision loss and blindness primarily through deterioration of the light-sensing cells of the retina, photoreceptors. Gene therapies offer the potential to address many of these retinal diseases, but we lack a safe, effective method to deliver gene editing molecules to photoreceptors. We are using new chemical approaches to make safe, effective vehicles to help genetic medicines reach photoreceptors and address the root cause of many retinal diseases.

PI_NAMEs: TUTTLE, ADAM  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;Affect;Animal Disease Models;Animal Model;Area;Bar Codes;Biologic Characteristic;Biological Assay;Biological Sciences;Blindness;Cells;Chemicals;Cholesterol;Clinical;commercialization;comparison control;COVID-19;CRISPR/Cas technology;Data;delivery vehicle;Deterioration;Development;DNA;DNA cassette;Encapsulated;Ensure;Evaluation;experimental study;FDA approved;Flow Cytometry;Fluorescence;follow-up;Follow-Up Studies;Formulation;Future;Gene Delivery;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;Genetic Medicine;genome editing;genome editor;Goals;Guide RNA;Head;Health;Hereditary Disease;Immune response;immunogenicity;improved;in vivo;Individual;Inherited;knock-down;Knock-out;knockout gene;Lead;Legal patent;Light;Link;Lipid Chemistry;lipid nanoparticle;Lipids;Marketing;Measures;Messenger RNA;Methods;Mission;Modification;mRNA delivery;multidisciplinary;Mus;mutation correction;nanoparticle delivery;Neurons;novel;nucleic acid delivery;Nucleic Acids;patient population;Patients;Peptides;Persons;Phase;Photoreceptors;prevent;Primates;protein aminoacid sequence;Publishing;Qualifying;Reporter;research clinical testing;Retina;Retinal Diseases;retinal toxicity;RNA;RNA delivery;RNA vaccine;Rodent;Safety;screening;Signal Transduction;Small Business Innovation Research Grant;Specificity;subretinal injection;Surface;System;Technology;Testing;Therapeutic;therapeutic development;therapy development;Tissues;Transfection;Viral;Viral Genes;Visual impairment;Work

PROJECT_TITLE: Delivering genetic medicines to photoreceptors with lipid nanoparticles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: San Diego

ORG_NAME: EMBRIENT INC

ORG_STATE: CA

PHR: Narrative Embrient Inc is pleased to submit our request for an HHS / SBIR / NIBIB grant, entitled, “Developing a Novel Incubator to Increase Cell Culture Reproducibility.” By funding this grant, you will support our efforts to design and test an incubator that employs laminar flow principles, aiming to achieve zero or near-zero chamber recovery time when the incubator door is opened. This innovation holds the promise that future cell culture experiments utilizing our incubator can maintain stable conditions akin to the human body, without the extensive fluctuations that affect the reliability of current market incubators. As a result, research outcomes will be more dependable and reproducible, advancing scientific progress.

PI_NAMEs: ROTHENBERG, BARRY E. (contact)

PROGRAM_OFFICER_NAME: HAPPEL, CHRISTINE MARIE

PROJECT_TERMS: Address;Affect;Air;Air Movements;Algorithms;Atmosphere;Carbon Dioxide;Cell Culture Techniques;cell growth;Cells;commercial application;cost estimate;Data Collection;design;Development;Diffusion;Environment;experimental study;Flying body movement;Funding;Future;Gases;Grant;Health;HIV;Human body;Humidity;Hypoxia Inducible Factor;improved;Incubated;Incubators;innovation;Laboratories;Left;Legal patent;Liquid substance;Literature;Machine Learning;Maintenance;Malaria;Manufacturer;Marketing;Measures;Modernization;Molecular Biology;National Institute of Biomedical Imaging and Bioengineering;Nobel Prize;novel;novel therapeutics;Outcome;Outcomes Research;Phase;Recording of previous events;Recovery;Refrigeration;Reliability of Results;Reporting;Reproducibility;Reproducibility of Results;Research;Research Personnel;Scientific Advances and Accomplishments;seal;Secure;sensor;Shapes;simulation;Small Business Innovation Research Grant;System;Technology;Testing;Time;tool;United States National Institutes of Health;user-friendly;virtual

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: EXTON

ORG_NAME: SERENTRIX, LLC

PHR: Project Narrative Burns have comprised 5-20% of military casualties sustained in post-World War II conflicts. There are no treatments for burn pain available that acts on specific pain receptors on the skin and can be applied topically. Our goal is to develop a novel topically applied TRPV1 antagonist for the treatment of cutaneous burn pain.

PI_NAMEs: BHARGAVA, KUMARIL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Admission activity;Adverse effects;Afferent Neurons;Alkalies;allodynia;Aloe vera plant;Anatomy;Animal Model;antagonist;Anti-Inflammatory Agents;aqueous;Back;Binding;Biological Assay;Burn injury;burn model;burn therapy;burn wound;Burning Pain;Capsaicin;Cicatrix;Clinical Trials;Cornea;corneal epithelial wound healing;Cream;Cutaneous;Development;Diffusion;Dosage Forms;Dose;drug candidate;Drug Formulations;Esthetics;Excipients;Experimental Designs;Eye;Family suidae;Formulation;Freund's Adjuvant;gabapentin;Gel;Generations;Goals;heat injury;Hospitals;Human;Hyperthermia;In Vitro;Indomethacin;Induced Neurons;Inflammation;Inflammatory;inflammatory pain;inhibitor;Injury;innovation;Intravenous;Knock-out;Knockout Mice;Lead;Legal patent;Link;lipid solubility;Liquid substance;Mediation;Military Personnel;Monitor;novel;Ointments;Opioid;Oral;Pain;Pain Measurement;pain model;pain receptor;pain reduction;pain relief;painful neuropathy;Patients;Penetration;Perforation;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase I Clinical Trials;Physiological;Play;porcine model;preservation;Process;programs;Property;Proteins;Protons;Rattus;receptor;Receptor Activation;Research;Rheology;Rights;Role;Route;safety study;Sampling;Severities;Skin;Skin injury;skin irritant;small molecule;Solubility;success;Surface;Symptoms;Tactile;Techniques;Testing;Time;Topical application;Toxicology;TRPV1 gene;Vanilloid;Wild Type Mouse;Work;World War II;wound healing

PROJECT_TITLE: Topical treatment for burn pain by blocking cutaneous pain receptors.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


ORG_CITY: Frisco

ORG_NAME: AAKHA BIOLOGICS INC.

PHR: PROJECT NARRATIVE Advanced metastatic lung cancer is difficult to treat because many tumors lack immune cells critical for fighting cancer. Aakha Biologics is developing a novel biologic drug that has the potential to both attract these immune cells to the tumor and activate them to kill the tumor. If successful, this biologic drug could provide a treatment for patients whose cancer is not responsive to currently available treatments. This project aims to complete studies that will further develop this biologic drug and ultimately support the submission of an application for a human clinical trial.

PI_NAMEs: BARUAH, HEMANTA  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: Animals;anti-PD1 therapy;Antibodies;antibody engineering;Antibody Therapy;Antigens;arm;Benchmarking;Binding;Biological;Biological Assay;Biological Products;Biophysics;Bispecific Antibodies;cancer cell;Cancer cell line;cancer type;cell killing;Cell Line;Cell surface;Cells;Cessation of life;chemotherapy;Clinical;Clinical Research;Clinical Trials;comparative efficacy;cytokine;Data;design;Engineering;Evaluation;FDA approved;fighting;Future;Goals;Grant;Human;Human Engineering;IgG1;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunologic Surveillance;Immunotherapy;improved;In Vitro;in vitro activity;in vitro Assay;in vivo;Interferon Type II;Interleukin-15;Intravenous;Knowledge;Lead;Literature;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Membrane;Meta-Analysis;Mica;Modeling;Monoclonal Antibodies;mouse model;MSLN gene;Mus;nanobodies;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;NK Cell Activation;Non-Small-Cell Lung Carcinoma;novel;Parents;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;prevent;Primary Neoplasm;Process;Production;Property;Refractory;Resistance;Safety;Serum;Small Business Innovation Research Grant;Specificity;subcutaneous;Surface;Survival Rate;synergism;targeted treatment;Technology;Testing;Therapeutic;timeline;tool;Toxic effect;tumor;tumor growth;tumor microenvironment;Variant

PROJECT_TITLE: A novel MICA/B based tumor-centric bispecific antibody that enhances NK cell activity in a hostile tumor microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The elderly have impaired capabilities to regulate their internal temperature, resulting in this population being susceptible to injuries and death during heat waves. This project seeks to identify and mitigate adverse thermal, cardiovascular, and renal responses during heat wave conditions in the elderly.

PI_NAMEs: MCKENNA, ZACHARY JOHN (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute Renal Failure with Renal Papillary Necrosis;age group;Aging;aging related;Air;Air Conditioning;American;Area;Attention;Attenuated;Body Temperature;Cardiac;Cardiovascular system;Caregivers;Cause of Death;Cessation of life;Chicago;Clinical Research;clinically relevant;Communities;cost;COVID-19;Data;design;Dryness;Echocardiography;efficacy evaluation;efficacy testing;Elderly;epidemiologic data;Experimental Designs;Exposure to;Extramural Activities;Fellowship;Frequencies;Funding;Future;Generations;global temperature;Goals;Government;Health;Heat Stress Disorders;Heat Waves;Home;Hospitalization;Household;Human;Humidity;Hyperthermia;Impairment;improved;Individual;indoor air;Industry;Injury;Injury to Kidney;Journals;Kidney;Libraries;Link;Liquid substance;Literature;Los Angeles;Low Income Population;Medical;Mentors;Metabolic;Methods;Mission;Modality;Natural Disasters;Outcome;Participant;Peer Review;Physicians;Physiological;Physiology;Population;Predisposition;prevent;Publishing;Regulation;Renal function;Research;Research Personnel;response;Risk;Scientist;simulation;skill acquisition;Skin;Stress;Technical Expertise;Temperature;Testing;Training;Translating;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Low-energy cooling strategies to reduce the thermal, cardiovascular, and renal consequences of heat waves in the elderly.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Accurate diagnosis and assessment of brain metastases in patients with systemic cancers has important implications for patient prognosis and treatment strategy. The proposed two-way magnetic resonance tuning nanoprobes and complementary subtraction imaging technology with ultra-high tumor-to-normal tissue ratios will provide neuroradiology practice with a highly capable, accurate and consistent approach for detecting and evaluating early brain metastases. This new imaging technology has great potential to be translated in clinic to improve survival and reduce the mortality rate in patients with brain metastases in the near future.

PI_NAMEs: LI, YUANPEI  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: accurate diagnosis;Acids;Biological;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;Breast Cancer Model;Cancer Detection;Cancer Etiology;Central Nervous System;Central Nervous System Neoplasms;Clinic;Clinical Treatment;contrast enhanced;Contrast Media;Coupled;crosslink;Crosslinker;Death Rate;design;Detection;Diagnosis;Diagnostic Procedure;Disease;Drug Kinetics;effective intervention;Encapsulated;Environment;ex vivo imaging;Fluorescence Resonance Energy Transfer;Future;Glucose;Goals;Image;imaging approach;imaging platform;Imaging technology;Immunotherapy;improved;in vivo;Journals;Legal patent;Licensing;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Modeling;Molecular;Molecular Diagnosis;mortality;Nanodelivery;nanoparticle;nanoprobe;Nanotechnology;nanotechnology platform;Nature;Neoplasm Metastasis;neoplastic cell;Newspapers;non-invasive imaging;Normal Cell;Normal tissue morphology;novel;Operative Surgical Procedures;patient derived xenograft model;patient prognosis;Patients;Penetration;pharmacologic;Population;pre-clinical research;Primary Brain Neoplasms;Primary Neoplasm;Publishing;Radiation;Resolution;Series;Sialic Acids;Signal Transduction;Site;SLC2A1 gene;Specificity;Surface;synergism;targeted treatment;Technology;Therapeutic;Time;Tissues;tool;Toxic effect;transcytosis;Translating;treatment strategy;tumor;tumor microenvironment;Tumor Tissue;Visualization;Work

PROJECT_TITLE: Two-way Magnetic Resonance Tuning Nanoprobe Enhanced Subtraction Imaging for Precision Diagnosis of Brain Metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-C (03)]


NIH_SPENDING_CATS: Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE  Exposure to high levels of environmental metals is known to be toxic, and the kidney is a harbinger of toxicity. Yet, current tests for kidney disease are insensitive for metal toxicity and do not evaluate the kidney tubules, which are the kidney components directly impacted by metals. With the development of novel non- invasive markers of kidney tubule damage, this program of research will harness these biomarkers to develop a kidney tubule monitoring panel that can be used to monitor populations at risk of metal toxicity, and to monitor the health impacts of programs that clean hazardous environmental metal contamination.

PI_NAMEs: IX, JOACHIM H;NAVAS-ACIEN, ANA ;SHLIPAK, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Address;Adult;Albuminuria;alpha-1-microglobulin;Arsenic;Biological Markers;biomarker panel;Blood;blood lead;Cadmium;Cardiovascular Diseases;cell injury;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic Kidney Failure;Cisplatin;Clinical;cohort;Communities;contaminated water;cooking;Creatinine;Development;diagnostic strategy;disorder risk;drinking;drinking water;EGF gene;Event;Exposure to;Failure;Fumarates;Functional disorder;Goals;ground water;Health;Heart;high risk;Hippuric acid;Household;human old age (65+);IL18 gene;Impairment;Incidence;Individual;Injury;Kidney;Kidney Diseases;Kidney Failure;Lead;Link;low socioeconomic status;Measures;Metal exposure;metal poisoning;Metals;Methods;Michigan;Mining;Minority Groups;Mississippi;Monitor;Multi-Ethnic Study of Atherosclerosis;Natural Source;nephrotoxicity;novel;novel diagnostics;Pharmaceutical Preparations;Population;Population Heterogeneity;Populations at Risk;Prevention;Preventive;programs;public health relevance;recruit;renal damage;Renal function;Renal tubule structure;Research;Resources;Risk Factors;Rural Community;Rural Population;rural setting;Safety;Serum;Site;specific biomarkers;Tenofovir;Testing;tool;Toxic effect;toxic metal;UMOD gene;Uranium;Urban Population;urban setting;Urine;Water;Water Supply;well water

PROJECT_TITLE: Environmental Metal Toxicity and Kidney Tubule Measures in Diverse Populations

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: GENETOBE INC.

ORG_STATE: MI

PHR: PROJECT NARRATIVE Gene editing therapy using Cas9 nuclease of Type II CRISPR promises a permanent cure for thousands of human diseases. In this proposal, we will develop novel tools by leveraging another major branch of CRISPR, the Type I systems. This work will tackle limitations of today’s gene- editing technologies to benefit human health.

PI_NAMEs: HOU, ZHONGGANG  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Adenine;Animal Model;Award;Awards and Prizes;base;base editing;base editor;BCAR1 gene;Biomedical Research;Cell model;cell type;Cells;Characteristics;Chemistry;Clinical;clinical application;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR/Cas technology;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cystinosis;Data;Databases;dbSNP;Deaminase;delivery vehicle;Dependovirus;design;Disease;disease-causing mutation;DNA;DNA Double Strand Break;efficacy evaluation;Elements;Endonuclease I;FDA approved;Fibroblasts;Foundations;gene editing technology;Gene Modified;gene therapy;Genes;Genetic Diseases;genome editing;genome editor;Genome engineering;Genomics;Guide RNA;head involution defective protein;Health;helicase;HIV;Human;human disease;Human Genetics;Human Genome;Impairment;in vivo;innovation;Length;Letters;Malignant Neoplasms;Market Research;Mediating;Mendelian disorder;Metagenomics;Methods;Mining;Mutate;Mutation;Nature;Neisseria lactamica;Nobel Prize;novel;nuclease;Nucleotides;off-target site;Orthologous Gene;Outcome;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phase;Positioning Attribute;pre-clinical;preference;Property;repaired;Reporting;Research;Safety;Sequence Deletion;Sickle Cell Anemia;Site;Solid;stoichiometry;System;Technology;Therapeutic;therapeutic genome editing;tool;tool development;trait;transition mutation;Translation Initiation;Variant;vector;Work

PROJECT_TITLE: Developing novel Type 1 CRISPR tools for gene editing therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Drugs of abuse, such as cocaine, are known to cause stable changes in neuronal function throughout the reward pathway and lead to drug-seeking and drug-taking, even following long periods of abstinence. Yet, the specific long-term molecular mechanisms that can lead to relapse remain unclear. The experiments in this proposal will examine the role of the histone modifying enzyme HDAC3 within the cholinergic population of medial habenula cells, and its role in mediating relapse cocaine-associated behaviors.

PI_NAMEs: ALIZO VERA, VANESSA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;addiction;Automobile Driving;Behavior;Behavioral;Bioinformatics;Brain;Cell Nucleus;Cell Physiology;cell type;Cells;Characteristics;Choline O-Acetyltransferase;cholinergic;Chromatin;Chromatin Structure;Chronic;Cocaine;cocaine relapse;cocaine related behaviors;cocaine seeking;conditioned place preference;Deacetylase;DNA Sequence;Drug Exposure;drug of abuse;drug seeking behavior;Enzymes;Epigenetic Process;epigenetic regulation;experimental study;Gene Expression;gene network;Genes;Genetic Transcription;Goals;Habenula;HDAC3 gene;HDAC4 gene;Histones;Immediate-Early Genes;Intravenous;long term memory;Medial;Mediating;Memory;memory process;Molecular;Mus;mutant;Nature;Neuronal Plasticity;Neurons;neuropsychiatric disorder;NR4A2 gene;Pathway interactions;Pharmaceutical Preparations;Physiological Processes;Population;Protocols documentation;Regulator Genes;Relapse;Repression;response;reward circuitry;Rewards;Role;Self Administration;Synaptic plasticity;Testing;Training;transcription factor;transcriptome;transcriptome sequencing

PROJECT_TITLE: Epigenetic Mechanisms Underlying Drug-seeking Behavior: Role of HDAC3 in Regulating Gene Expression within the MHb Cholinergic Population for Cocaine-induced Relapse-like Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Springfield

ORG_NAME: OREGON RES BEHAVIORAL INTERVENTION STRAT

PHR: Project Narrative  In this Phase I SBIR, we propose to develop a prototype of the HealthyU-Native program conceptualized to improve the success of secondary Native American and Alaskan Native (NA/AN) students when engaging with health information, processes, and institutions by providing a culturally responsive, web/mobile app-based health literacy curriculum. The product will support students in school and community settings. Ultimately, reducing disparities in health literacy will lead to improved health outcomes for NA/AN students providing personal, social, and economic benefits.

PI_NAMEs: HAMILTON, ALEXANDRA ;HUSCROFT-D'ANGELO, JACQUELINE ;MARQUEZ, JESSIE  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Academy;Address;Adolescent;Adult;after-school program;Alaska Native;Alaska Native population;American;animation;Attitude;Behavioral;Benchmarking;Caring;Centers for Disease Control and Prevention (U.S.);Chronic;Collaborations;commercially viable technology;Communities;Community Health;community organizations;community setting;Consumer Satisfaction;Country;Coupled;Data;design;Development;Disease;disorder prevention;disparity reduction;Economics;Educational Curriculum;efficacy evaluation;Elderly;Emergency medical service;Ethics;Evaluation;Exercise;experience;Face;Family;Feedback;Focus Groups;Genetic Transcription;hands-on learning;healing;Health;health care availability;Health care facility;health disparity;health literacy;Health Personnel;Health Promotion;Healthcare;High School Student;Hospitals;improved;Infrastructure;insight;Institute of Medicine (U.S.);Institution;Instruction;Insurance;Intention;Internet;iterative design;Knowledge;Learning;Life Expectancy;low health literacy;Marketing;Medical;Medical emergency;Medication Management;member;mobile application;mobile delivery;Modeling;Multimedia;Native Americans;native youth;Online Systems;Outcome;Pediatrics;Phase;phase 2 testing;poor health outcome;Population;Preparation;Preventive service;Printing;Privatization;Process;programs;prototype;Public Health Education;Quality of life;randomized trial;Resources;Risk;Salmo trutta;satisfaction;school health;School-Age Population;Schools;Self Efficacy;Self Management;Services;skills;Small Business Innovation Research Grant;social;Societies;Students;success;Surveys;System;Technology;technology platform;Testing;tool;Tribal School;United States;United States Dept. of Health and Human Services;United States Indian Health Service;usability;Visit;World Health Organization;Youth

PROJECT_TITLE: HealthyU-Native: A Technology-Based Tool for Addressing Health Literacy in Native American/Alaska Native Secondary Students

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Prevention;Substance Misuse

ORG_CITY: Peachtree Corners

ORG_NAME: KASA BIO, L.L.C.

ORG_STATE: GA

PHR: Project narrative (Public Health Relevance)  Globally, liver diseases are on the rise. At least half of people living with type 2 diabetes have nonalcoholic fatty liver disease and are at higher risk to develop nonalcoholic or alcohol associated steatohepatitis and cirrhosis. miRNA signatures are considered as potential diagnostic and prognostic biomarkers for human diseases. Recently, miRNA-based diagnostic tests using RT-qPCR technology are being used to detect cancers. The goal of this grant application is to develop a high multiplex RT-qPCR method that enables the detection of multiple miRNAs from various specimens in a single reaction on existing qPCR systems. Many liquid biopsy applications (such as liver and metabolic diseases, oncology, neurological and cardiovascular diseases), that require analysis of multiple miRNAs, will highly benefit from this technology.

PI_NAMEs: BALA, SHASHI  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acceleration;Alcoholic Liver Diseases;Alcohols;Applications Grants;Biological Assay;Biological Markers;Biological Sciences;biomarker discovery;Body Fluids;Businesses;Cancer Detection;Cardiovascular Diseases;Cell Line;Cessation of life;Cirrhosis;Clinical;clinical application;Clinical Oncology;Clinical Research;Computer software;cost;cost effective;cross reactivity;Custom;Data;design;Detection;detection assay;detection limit;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic biomarker;Diagnostic tests;Disease;Early Diagnosis;Economics;Evaluation;Friends;Future;Goals;Growth;high risk;high throughput technology;human disease;interest;Ligation;liquid biopsy;Liver;Liver diseases;Malignant neoplasm of thyroid;malignant stomach neoplasm;Market Research;Marketing;melting;Metabolic Diseases;Methodology;Methods;microRNA biomarkers;MicroRNAs;Modeling;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;multiplex assay;multiplex detection;Nervous System Disorder;non-alcoholic;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Oncology;Performance;Persons;Phase;point of care;Polynucleotide Adenylyltransferase;Process;Prognostic Marker;public health relevance;Reaction;Reagent;Reporting;Research;research clinical testing;Resource-limited setting;Resources;Reverse Transcription;RNA;Sampling;screening;Small Business Innovation Research Grant;Specificity;Specimen;statistics;Steatohepatitis;System;Technology;Testing;Time;Tissues;tool;Translational Research;treatment response;Validation

PROJECT_TITLE: A novel and inexpensive multiplex miRNA platform for liver diseases screening


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: San Francisco

ORG_NAME: FLUID DISCOVERY INC

PHR: NARRATIVE Fluid Discovery aims to commercialize a single-cell proteomics approach, Self-Assembled Partitioning Proteomics (SAP-pm), for Alzheimer's research – enabling the quantification of thousands of proteins in hundreds of thousands of individual cells, while being multiplexed with DNA and RNA sequencing. This innovative approach overcomes limitations of existing technologies and allows for tri-omic profiling, shedding light on the mechanisms of proteomic dysregulation and unveiling new therapeutic targets.

PI_NAMEs: PRINCE, ROBIN  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Accounting;Alzheimer's Disease;Alzheimer's disease brain;Basic Science;Binding;Biological;Biophysics;Brain;Cell Nucleus;Cells;Cellular biology;commercialization;Complex;cost effective;Data;Dementia;Development;Disease;DNA sequencing;Epitopes;Genetic Fingerprintings;Genomics;Health;health application;Human;human tissue;improved;Individual;innovation;insight;Kinetics;Light;Liquid substance;Maps;Messenger RNA;Methods;Microfluidics;Molecular;Nervous System Disorder;new technology;new therapeutic target;novel strategies;Nucleic Acids;Patients;Process;Protein Analysis;protein purification;Proteins;Proteomics;Research;RNA;self assembly;Societies;Stains;Techniques;Technology;Therapeutic;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: WALTHAM

ORG_NAME: FLEXOMICS LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Single cell genomics technologies have had a tremendous impact on our understanding of the fundamental unit of life but lack the ability to collect simultaneous dynamic functional cellular analysis. The proposed technology combines imaging-based dynamic phenotyping and genomic analysis at single cell level in a high-throughput manner. This new approach has the potential to impact and expand functional single cell analysis beyond existing solutions.

PI_NAMEs: SOUMILLON, MAGALI  (contact)

PROGRAM_OFFICER_NAME: PILLAI, AJAY

PROJECT_TERMS: Adoption;Bar Codes;Biological;Biological Assay;Capital;Cell Communication;Cell Separation;cell type;Cells;Cellular Assay;cellular imaging;Clinical;combinatorial;commercialization;Complex;computerized data processing;cost;cytokine;Data;Data Analyses;data visualization;Databases;Dedications;density;design;Disease;Ensure;Event;Experimental Designs;flexibility;fluorescence imaging;Fluorescence Microscopy;Frequencies;Gene Expression;Genetic Markers;Genomics;Genotype;Grant;Heterogeneity;Image;Individual;Libraries;Life;Link;Mainstreaming;Malignant neoplasm of ovary;manufacturing scale-up;Measurement;Measures;Molecular;Molecular Profiling;neoantigens;new technology;next generation;novel;novel strategies;Nucleic Acids;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Population Heterogeneity;Positioning Attribute;Privatization;programs;Property;prototype;Publications;Research;Research Project Grants;response;Sampling;Scheme;screening;Serous;single cell analysis;single cell genomics;Site;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Time;tool;Training;transcriptome;Visualization software;Work

PROJECT_TITLE: A novel flexible approach for high-throughput single-cell phenotyping and genotyping


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: TAMPA

ORG_NAME: IMMERSIVE TECH, INC.

ORG_STATE: FL

PHR: NARRATIVE Public Health Relevance Immertec has developed software to stream high-quality stereoscopic video to virtual reality (VR) devices for remote medical training in real-time. Immertec's technology provides options for clinicians to learn specialty procedures and use of new medical devices without traveling to onsite training by allowing a healthcare practitioner from any location to attend live training courses with specialists from a distant hospital or simulation center, interact with critical biomedical image feeds, and converse with a remote instructor or peers. Immertec's technology takes a step toward mitigating health disparities in underserved rural communities that have limited access to medical specialists by providing more options for remote training of specialty medical knowledge.

PI_NAMEs: BAILEY, SHANNON KYLE TEDDER;BURNS, MICHEAL  (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Agreement;Algorithms;Benchmarking;biomedical imaging;blind;Businesses;Caring;Collaborations;Communication;Computer software;Control Groups;cost;cost effective;dashboard;Data;Data Correlations;data dashboard;design;Development;Devices;Discipline of obstetrics;Distant;Dystocia;Educational Curriculum;Educational process of instructing;Emergency Medicine;Emergency Situation;Equipment;Evaluation;evidence base;experience;Feeds;Florida;Future;General Practitioners;Geographic Locations;Geography;Goals;Health;health care availability;Health Personnel;Healthcare;high risk;Hospitals;Image;implementation cost;Improve Access;improved;Industry;innovation;Institutional Review Boards;Instruction;instructor;Joints;Knowledge;Learning;learning materials;learning outcome;Legal patent;live stream;Location;Measures;Medical;Medical Device;Medical emergency;Medical Residency;medical specialist;medical specialties;Methods;Modeling;novel;Outcome;Participant;Patient Care;Patients;peer;Performance;Persons;Phase;Physicians;poor health outcome;Postpartum Hemorrhage;Preparation;Procedures;programs;public health relevance;Reduce health disparities;remote location;Reporting;Residencies;Resources;Rural;rural area;Rural Community;rural healthcare;rural underserved;Shoulder;simulation;Site;Small Business Innovation Research Grant;software development;Specialist;stereoscopic;Stream;success;symposium;System;Taxes;Technology;Telemetry;Testing;Time;Training;Training Programs;Translations;transmission process;Travel;underserved rural area;United States National Institutes of Health;Universities;urban area;usability;Videoconferencing;virtual assessment;virtual reality;virtual reality headset;virtual reality system;Writing

PROJECT_TITLE: Advancing emergency medicine training with remote stereoscopic livestream technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]