ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: PROJECT NARRATIVE This research is designed to contribute fundamental knowledge about the multimorbidity of HIV, geriatric syndromes comprising frailty, depression and cognitive decline, and oral health in older adults living with HIV in Sub-Saharan Africa as well as mechanisms of integrating oral health into routine HIV care. We envisage that our findings will contribute to better understanding of the oral disease burden with comorbid geriatric syndromes and HIV in older adults that can be used to develop prevention, early detection, and treatment strategies to improve overall health for all individuals and communities across the lifespan.

PI_NAMEs: CHAMUT VILLARREAL, STEFFANY ;MALING, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Administrator;Adult;Affect;Africa;Africa South of the Sahara;African;Age;age effect;aged;aging related;antiretroviral therapy;Area;Behavioral;Biochemistry;Biological;burden of illness;care recipients;care systems;Caring;Clinical;clinical care;Clinical Research;Clinical Trials;co-infection;cohort;Communities;comorbidity;Dental caries;Dental Epidemiology;design;Development;Disease Progression;Early Diagnosis;Elderly;Epidemiology;EuroQOL;Foundations;frailty;Funding;Future;Gender;Goals;Guidelines;Health;health care service;Health Disparities Research;health disparity;health related quality of life;Health Services;Health system;Healthcare;high risk;high risk population;HIV;HIV Infections;HIV/AIDS;Impaired cognition;improved;Incidence;Individual;informant;Intervention;Intervention Studies;Interview;Investigation;Knowledge;life span;Longitudinal cohort;Measures;Mental Depression;Mental Health;mild cognitive impairment;Modeling;Mouth Diseases;multidisciplinary;multiple chronic conditions;National Institute of Dental and Craniofacial Research;neglect;Neurocognition;Neurocognitive Deficit;older adult;Older Population;Oral;Oral Examination;Oral health;Outcome;Periodontal Diseases;permanent tooth;Personal Satisfaction;Persons;Physicians;Policy Maker;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Prevention;Preventive;programs;Provider;Psyche structure;Public Health;Quality of life;Questionnaires;Research;Research Infrastructure;Research Methodology;Research Priority;Resource-limited setting;Risk;Risk Factors;Rural;Scientist;Services;social culture;Social Functioning;Syndrome;therapy design;treatment strategy;Uganda;United States National Institutes of Health;Xerostomia;years lived with disability

PROJECT_TITLE: Oral diseases and quality of life in older adults on anti-retroviral therapy in Uganda (ODQoL-UG)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: Project Narrative This project will examine the impact of school-based health centers (SBHCs) in California and Oregon on health care utilization, cost, health outcomes, and education outcomes overall and for members of health disparity populations. By using multiple years of health insurance claims data, survey data, education data, and information on students' access to SBHCs, we will estimate the causal impacts of students' access to SBHCs in a difference-in-difference model which leverages variation in the availability of SBHCs over time and across communities. We will also examine the dimensions on which SBHC impacts vary, including location, services offered, size, and the pandemic to inform the operation of current SBHCs and design of future SBHCs.

PI_NAMEs: KRANZ, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Adolescent;adolescent health;Award;barrier to care;Black race;California;Caring;Characteristics;Child;Child Care;Child Development;Child Health;Childhood;Communities;Comprehensive Health Care;Congresses;cost;Counseling;COVID-19;COVID-19 pandemic;Data;Data Set;Delaware;design;Diet;Dimensions;Disparate;Disparity population;disparity reduction;Education;elementary school;Enrollment;Equity;Ethnic Origin;experience;Funding;Future;Growth;Health;Health Care Costs;health care disparity;health care service utilization;health disparity;health disparity populations;health equity promotion;Health Insurance;Health Services Accessibility;Health Surveys;Healthcare;Healthcare promotion;High School Student;Hispanic;Household;Immunization;improved;Income;Insurance;insurance claims;Link;Location;Low income;Medicaid;member;Mental Health Services;Methods;Modeling;National Institute of Child Health and Human Development;operation;Oregon;Outcome;pandemic disease;Patients;Population;Population Heterogeneity;Positioning Attribute;Primary Care;protective effect;Race;Recommendation;Reduce health disparities;Reporting;Reproductive Health Services;Research;rural area;rurality;Sample Size;Sampling;school based health center;School-Age Population;Schools;screening;Selection Bias;service delivery;Services;Site;Strategic Planning;Students;Surveys;Time;Transportation;United States Health Resources and Services Administration;Vaccination;Variant;Well Child Visits

PROJECT_TITLE: Impact of School-Based Health Centers on Improving Health and Promoting Equity

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project narrative  How Origin Recognition Complex (ORC) accurately executes its roles during normal cell cycle and in disease, remains long-standing question in the field. The smallest and most enigmatic of ORC subunits, Orc6 protein, is important for DNA replication in all eukaryotes and also has a function in cytokinesis. Our goal is to define the distinct mechanisms of metazoan Orc6 functions using Drosophila as a model system.

PI_NAMEs: CHESNOKOV, IGOR N (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: autosome;Basal Cell Nevus Syndrome;Biological Models;Cell Cycle;Cells;Complex;Cytokinesis;Cytoskeleton;Defect;Development;Disease;DNA biosynthesis;Drosophila genus;Dwarfism;Eukaryota;Goals;Growth;Human;Impairment;insight;Molecular;Mutation;Normal Cell;origin recognition complex;Phenotype;Pre-Replication Complex;Protein Complex Subunit;protein function;Proteins;Research;Role;Structure

PROJECT_TITLE: DNA Replication and Cytokinesis.

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: Project Narrative: Fetal alcohol spectrum disorder (FASD) is a significant non-genetic neurodevelopmental disability in which affected individuals display cognitive and social abnormalities. The studies herein examine the cell-type-specific cannabinoid receptor-epigenetic mechanism by which postnatal ethanol exposure causes cognitive and social- behavioral defects. The findings will address our knowledge gap in understanding cell-type-specific CB1 mediated epigenetic mechanisms and inform us why the developmental brain is, therefore, vulnerable to alcohol's damaging effects. Moreover, the findings of the proposed studies may be used by health care professionals in counseling women on the potential adverse impacts of alcohol abuse during pregnancy.

PI_NAMEs: BALAPAL, BASAVARAJ S (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adult;Adult Children;Affect;Affinity Chromatography;alcohol abuse during pregnancy;alcohol effect;alcohol exposure;Alcohols;Animals;Attention;Behavioral;behavioral impairment;behavioral outcome;binge drinking;Brain;Breeding;cannabinoid receptor;CB1 knockout;cell type;CNR1 gene;Cognitive;comparison control;conditional knockout;Counseling;Data;Defect;Development;effective therapy;Electron Microscopy;Enhancers;Enzymes;Epigenetic Process;Epitopes;Event;Female;fetal;Fetal Alcohol Spectrum Disorder;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Glutamates;Goals;Golgi Apparatus;Health Professional;Hemagglutinin;Hippocampus;histone methylation;Histones;Human;Immunoprecipitation;Impairment;in vivo;Individual;Knowledge;Laboratories;Learning;Life;Long-Term Potentiation;LoxP-flanked allele;Lysine;male;maternal alcohol use;Mediating;Memory;Memory impairment;memory recognition;Messenger RNA;Methods;Methylation;Modeling;Molecular;mouse model;Mus;neonatal mice;Nerve Degeneration;Nervous System Disorder;neurobehavioral;Neurodevelopmental Disability;Neurodevelopmental Disorder;Neurons;new therapeutic target;non-genetic;novel;offspring;Pathway interactions;Polyribosomes;postnatal;Prefrontal Cortex;Pregnancy;Prevention strategy;Prosencephalon;Proteins;Psychopathology;pup;recombinase;Regulation;Reporting;Research;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RiboTag;Role;sex;Signal Transduction;social;Social Behavior;Stains;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Tamoxifen;Technology;Teratogenic effects;Testing;Therapeutic Intervention;therapeutic target;Third Pregnancy Trimester;Transcript;transcription factor;Transcriptional Regulation;Translating;Translations;translatome;vapor;Vertebral column;Woman

PROJECT_TITLE: CB1-mediated signaling in developmental ethanol effects

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inherited mutations in telomere maintenance genes can cause life threatening diseases including bone marrow failure, liver cirrhosis, and pulmonary fibrosis, which have limited therapeutic options. Using human population genetic data and high throughput genetic screening, we identified a novel connection between nucleotide metabolism and human telomere homeostasis. This proposal aims to uncover the mechanisms underlying this connection, with implications for the treatment of telomere biology disorders and potentially other degenerative diseases.

PI_NAMEs: MANNHERZ, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Academic skills;Age;Aplastic Anemia;Award;Biochemical;Bioinformatics;Biology;Blood Cells;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;Boston;career;career preparation;Cell division;Cells;Childhood;Chromosomes;Communication;CRISPR screen;Data;Defect;Degenerative Disorder;Deoxyribonucleotides;design;Diagnosis;Disease;DNA;Dyskeratosis Congenita;Dysmyelopoietic Syndromes;Environment;experience;experimental study;Face;Future;Genes;Genetic;Genetic Screening;Genetic study;Genome Stability;genome wide association study;genome wide screen;genome-wide;Goals;Growth;Health;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Homeostasis;Human;Human Cell Line;Human Genetics;Human Genome;human model;human population genetics;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Inherited;Intervention;Investigation;Knowledge;Laboratories;Length;Life;Link;Liver Cirrhosis;loss of function;medical schools;Mentors;Metabolism;metabolomics;Modeling;mutant;Mutation;novel;novel strategies;nucleotide metabolism;Nucleotides;Organ failure;Organ Transplantation;Outcome;Output;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pediatric Hospitals;Physicians;Physiological;Population;Predisposition;Prevalence;prevent;Prognosis;promoter;protein structure;Pulmonary Fibrosis;Regenerative capacity;regenerative tissue;Regulation;Research;Risk;RNA-Directed DNA Polymerase;Role;Scientist;senescence;small molecule;Somatic Mutation;Supplementation;Supportive care;Systemic disease;Systemic Therapy;Telomerase;telomere;Telomere Maintenance;Telomere Maintenance Gene;Telomere Shortening;TERT gene;Testing;Therapeutic;Thymidine;Training Programs;Translating;Translations;Transplant Recipients;Work

PROJECT_TITLE: Control of Telomere Homeostasis by Nucleotide Metabolism in Hematopoiesis


NIH_SPENDING_CATS: Cancer

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  The proposed research is of high significance because it defines the functional mechanism of a major sphingosine-1-phosphate (S1P) transporter Spns2, a bioactive lipid important to regulating the growth, survival and migration of mammalian cells with profound proangiogenic effects. The project is relevant to public health because it will lay the foundation for the development of new therapeutic strategies for diseases associated with S1P signaling and to target Spns2 as a potential immunosuppressant. An innovative aspect of this proposal is the application of a suite of integrated biophysical methods to characterize the transport and regulatory mechanisms of Spns transporters.

PI_NAMEs: DASTVAN, REZA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adopted;Antibiotics;Binding Sites;Biological Assay;biophysical techniques;Cations;Cell membrane;cell motility;Cells;Cellular Membrane;conformational conversion;Coupled;Coupling;Cryoelectron Microscopy;Data;Defect;Detergents;Development;Disease;Drug Targeting;efflux pump;Electron Spin Resonance Spectroscopy;Electrons;Endothelial Cells;extracellular;Family;Family member;feasibility research;flexibility;Foundations;genome-wide;Goals;Growth;Homologous Gene;Human;Immune system;Immunosuppressive Agents;Immunotherapy;Impairment;In Vitro;in vivo;innovation;Inorganic Phosphate Transporter;Ions;Ligands;Lipid Bilayers;Lipids;Lymphocyte;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Membrane;Membrane Lipids;Micelles;migration;mimetics;model building;Modeling;Molecular Conformation;molecular dynamics;molecular modeling;Multi-Drug Resistance;Mus;mutant;Mutation;Mycobacterium smegmatis;nanodisk;nanoscale;Neoplasm Metastasis;Neptunium;novel therapeutic intervention;particle;Physiologic pulse;Physiological;Play;Poison;prevent;Proteins;protonation;Protons;Public Health;Regulation;Research;Resolution;restraint;Role;Sampling;Signal Transduction;simulation;Spectrum Analysis;Sphingolipids;sphingosine 1-phosphate;Spin Labels;stoichiometry;structural determinants;Structure;Techniques;Testing;Therapeutic;therapeutic target;tumor

PROJECT_TITLE: Structural dynamics of sphingosine-1-phosphate transporters as key therapeutic targets for immune system modulation and cancer

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Cancer clinical trials require clinician investigators to develop trials and monitor their progress, review safety data, and respond to human subjects concerns. This Research Specialist award application seeks funding for an accomplished clinical trialist at the Medical College of Wisconsin (MCW) to partially support their effort devoted to National Cancer Institute-funded clinical trials research in the Cancer Center. Such support will facilitate further increasing the quality and number of trials at the applicant’s institution by supporting the Clinician Scientist’s contributions to developing national trials, implementing NCI trials at MCW, and performing service to the NCI clinical trials networks.

PI_NAMEs: HAMADANI, MEHDI HUSSAIN (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Adult;Award;Blood;Bone Marrow Transplantation;Cancer Center;cancer clinical trial;Cancer Patient;cancer research center director;career;Cell Therapy;Clinic;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Clinical Trials Network;Data;Disease;Funding;Hematology;human subject;improved;Industry;inpatient service;Institution;Leadership;Maintenance;Malignant - descriptor;Medical;medical schools;Medicine;Monitor;National Cancer Institute;Operations Research;Outpatients;participant enrollment;Patients;Play;Principal Investigator;Procedures;Process;professor;programs;Protocols documentation;Research;Research Personnel;Role;Safety;Scientist;Services;Specialist;success;therapy outcome;Time;transplantation therapy;United States National Institutes of Health;Wages;Wisconsin

PROJECT_TITLE: Clinician Scientist Supporting NCI-funded Clinical Trials at the Medical College of Wisconsin Cancer Center


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Individuals who use alcohol and marijuana simultaneously are at increased risk for developing substance use disorders. The proposed project aims to understand how simultaneous use leads to increased risk for negative outcomes by examining the brain’s response to stress cues, neuroendocrine responses to stress cues, and relationships between stress, craving, and drug use in the real world. By elucidating brain and behavioral mechanisms, it may be possible to identify treatments to prevent or reduce the negative consequences of simultaneous use.

PI_NAMEs: ANSELL, EMILY B (contact);CLAUS, ERIC D

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Address;Alcohol consumption;alcohol craving;alcohol response;Alcohols;Behavior;Behavioral;Behavioral Mechanisms;binge drinker;Biological;Blood;blood oxygen level dependent;Brain;Cannabis;cannabis craving;comparison control;Consumption;Control Groups;Corpus striatum structure;craving;cue reactivity;Cues;Data;Drug usage;Ecological momentary assessment;Exhibits;experience;Female;follow-up;Functional Magnetic Resonance Imaging;Future;Heavy Drinking;Hydrocortisone;Individual;Individual Differences;Intervention;Knowledge;Life;male;Marijuana;marijuana legalization;marijuana use;marijuana user;Measurement;Measures;neural;neurobehavioral;neuroimaging;Neurosecretory Systems;Outcome;Participant;Pathway interactions;Pattern;Persons;Plasma;prevent;Prevention;Process;prospective;recruit;Reporting;response;Risk;Risk Factors;Role;Sampling;secondary analysis;sex;Sex Differences;Stress;substance use;Substance Use Disorder;substance user;Time;time interval;women versus men;Work

PROJECT_TITLE: Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Disability Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Physical Rehabilitation;Rare Diseases;Rehabilitation;Sepsis

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Patients who survive an acute critical illness including sepsis, COVID-19, influenza and acute respiratory distress syndrome often develop physical disability that can persist for years after hospital discharge. The planned proposal will determine cellular and clinical parameters responsible for the reduced or inability to recover muscle and physical function after critical illness. The findings of this study will inform the development of future therapeutic interventions that mitigate long-term impairments and stimulate muscle and physical recovery after critical illness.

PI_NAMEs: DUPONT-VERSTEEGDEN, ESTHER E (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Adult;Age;Area;Attention;Automobile Driving;Awareness;Biopsy;Cells;Characteristics;Chronic disability;Clinical;Collagen;Communities;comorbidity;COVID-19;Critical Illness;Data;Deposition;Deuterium Oxide;Development;disability;disabled;Disparate;Environment;Equilibrium;Etiology;evidence base;Extracellular Matrix;Fatigue;Fibrosis;Functional disorder;Future;Goals;Growth;Hospitalization;Hospitals;Immune;Immune response;Impairment;improved;Inflammation;Inflammatory;Influenza;Intensive Care Units;interest;Intervention;Knowledge;Label;Lifelong disability;Long term disability;Long term physical disability;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Mission;Mitochondria;Muscle;Muscle Fibers;Muscle function;muscle progenitor cell;muscle strength;Muscle Weakness;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;nutrition;Observational Study;Outcome;participant enrollment;patient subsets;Patients;Pattern;pharmacologic;Pharmacological Treatment;Phenotype;Physical Function;physical impairment;physically handicapped;Pneumonia;predictive modeling;protein biomarkers;protein degradation;Proteins;proteostasis;Quality of life;Recovery;Recovery of Function;Rehabilitation therapy;Research;Research Project Grants;Respiration;response;Sepsis;sepsis induced ARDS;Severity of illness;Signal Pathway;Skeletal Muscle;skeletal muscle wasting;stable isotope;Survivors;therapeutic development;Therapeutic Intervention;therapy development;Time;Tissue Sample;Tissues;United States;Work

PROJECT_TITLE: Muscle and physical function recovery after acute critical illness

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative It is estimated that 10-25% of human embryos have the wrong number of chromosomes, resulting in a high incidence of miscarriages and birth defects. Most of these abnormalities are the result of mistakes generated when female reproductive cells (oocytes) divide, yet surprisingly little is known about the mechanisms that underlie the vulnerability of oocytes to these errors. This project seeks to gain insight into this important question, focusing on how a structure called the spindle mediates the alignment and segregation of chromosomes during cell division.

PI_NAMEs: WIGNALL, SARAH MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acute;Aneuploidy;Area;Auxins;Biological Assay;Biology;Caenorhabditis elegans;Cell division;cell type;Cells;Cellular Morphology;Centrosome;Chromosome abnormality;chromosome movement;Chromosome Pairing;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;Coupled;Coupling;Data;Defect;defined contribution;density;Embryo;Ensure;Female;Germ Cells;Goals;Haploidy;Health;Human;Image;Incidence;Individual;insight;Kinesin;Kinetochores;Lateral;Mediating;Meiosis;Metaphase Plate;Methods;Microtubule Bundle;Microtubules;Modeling;Multiprotein Complexes;Mus;novel;Oocytes;Organism;Phosphorylation;Phosphotransferases;Play;PLK1 gene;polo-like kinase kinase 1;Pregnancy;Process;programs;protein complex;Proteins;Regulation;Reproduction;Reproductive Biology;Role;Running;Side;Spontaneous abortion;Structure;System;tool;Work

PROJECT_TITLE: Regulation of chromosome segregation during oocyte meiosis

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Precision Medicine;Rare Diseases;Social Determinants of Health

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE In 2021, it is estimated that there will be approximately 61,000 new cases with 23,660 deaths occurring from leukemia. The goal of this project is to reduce the impact of leukemia by supporting clinician-scientists conducting clinical trials sponsored by the National Cancer Institute at Washington University School of Medicine / Siteman Cancer Center and nationally. These trials will test novel therapies and prioritize a precision medicine approach where molecular testing is used to select patients who may most benefit from treatments targeting specific genetic abnormalities present in their leukemia.

PI_NAMEs: UY, GEOFFREY L (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Biological;Cancer Center;Cessation of life;Clinical;clinical implementation;Clinical Research;Clinical Trials;Companions;Conduct Clinical Trials;Disease remission;Ensure;Flow Cytometry;Funding;Geriatric Assessment;Goals;health disparity;improved;Institution;Leadership;leukemia;Malignant Neoplasms;Measurable;Measures;medical schools;Molecular;Molecular Abnormality;Myeloproliferative disease;National Cancer Institute;novel therapeutics;older adult;Oncology;Patient Selection;Patients;Physician Executives;precision medicine;Precision Medicine Initiative;Prediction of Response to Therapy;prognostic significance;programs;Protocol Compliance;Research;Residual Neoplasm;Scientist;social health determinants;targeted treatment;Testing;treatment trial;Underrepresented Minority;Universities;Washington

PROJECT_TITLE: Clinician Scientist in Leukemia


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Uterine Cancer;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Through existing and innovative partnerships and clinical trial networks, this proposal will provide improved access to NCI clinical trials to patients at the Masonic Cancer Center of the University of Minnesota, the Minneapolis/St Paul metropolitan area and, ultimately, to greater Minnesota. In addition, the support of the proposed Research Specialist, Britt Erickson, MD, will lead to enhanced development of national clinical trials specific to endometrial cancer, a leading and rising cause of death from gynecologic malignancies in the US. Knowledge gained from these clinical trials will lessen the burden of cancer and improve existing disparities in cancer treatment outcomes.

PI_NAMEs: ERICKSON, BRITT KRISTINA (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Area;Body of uterus;Cancer Burden;Cancer Center;cancer clinical trial;Cancer Control;cancer health disparity;cancer prevention;Cause of Death;Clinical;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Communities;Community Medicine;Development;Disease;Endometrial Carcinoma;Enrollment;ERBB2 gene;Exemestane;experience;Funding;Gynecologic Oncology;Health;health care delivery;Improve Access;improved;Infrastructure;innovation;Knowledge;Leadership;Location;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;member;mentoring community;Mentors;metropolitan;Minnesota;Mission;Native American population;novel;Oncologist;Oncology;Patients;Phase;Prevention trial;Principal Investigator;Process;Protocols documentation;public health relevance;Research;Review Committee;Role;Rural;service delivery;Services;Site;skills;Specialist;success;Therapeutic Clinical Trial;Therapeutic Trials;Treatment outcome;Universities;University of Minnesota Cancer Center;Vision;Work

PROJECT_TITLE: Increasing access to cancer trials in Minnesota (InACT-MN)


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Obesity is fundamentally a disorder of energy balance that occurs when energy intake exceeds energy expenditure, resulting in increased energy storage in the form of triglyceride within white adipose tissue. This proposal aims to discover the molecular mechanisms by which energy-storing white adipocytes suppress their natural energy-burning potential. Understanding these mechanisms may lead to therapeutic strategies to unlock the energy-burning capacity of adipose tissue to promote weight loss and/or improve nutrient homeostasis.

PI_NAMEs: TRUONG, ASHLEY T (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acetylation;Address;Adipocytes;Adipose tissue;Adopted;Adult;Amino Acids;Binding;Biochemical;Biochemistry;Body Weight;Body Weight decreased;Brown Fat;Cellular Assay;Characteristics;chromatin remodeling;Clinical;comorbidity;Complex;Data;design;Disease;Doctor of Philosophy;energy balance;Energy Intake;Energy Metabolism;Engineering;experimental study;Family;feeding;Financial Hardship;Gene Expression;gene function;Genes;Genetic;genetic corepressor;Genetic Transcription;Goals;Healthcare Systems;High Fat Diet;Homeostasis;Homologous Gene;Human;improved;in vivo;Incidence;Individual;insight;Intervention;Light;Maintenance;Maps;Mediating;Medical;member;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modeling;Molecular;Molecular Biology;mortality;mouse genetics;mouse model;Mus;mutant;NuRD complex;Nutrient;Obesity;obesity development;Orthologous Gene;Outcome;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Potential Energy;prevent;Process;programs;Protein Isoforms;protein protein interaction;Proteins;Rana;recruit;Repression;Research;response;Role;Scientist;Testing;Therapeutic;Thermogenesis;Tissues;Training;Training Programs;transcription factor;Triglycerides;United States;Universities;Variant;Work;Zinc Fingers

PROJECT_TITLE: Elucidating the Transcriptional Brakes on Adipocyte Thermogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Each year, millions of people are harmed or killed by viruses that spill over from wild or domestic animal reservoirs, and in some cases these spillovers result in devastating pandemics. One new avenue for suppressing these animal pathogens is to develop self-disseminating animal vaccines that block the viruses at their source and prevent them from spilling over into the human population. This project uses a combination of mathematical models and laboratory studies to develop a framework for designing self-disseminating vaccines and optimizing their performance.

PI_NAMEs: NUISMER, SCOTT L (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Animals;Automobile Driving;Brucella;Chronic;Collaborations;Combined Vaccines;cost;Cytomegalovirus;design;Development;Disease;Domestic Animals;Ebola;Effectiveness;Engineering;Epidemic;Evolution;experimental study;Face;Foundations;Genetic Engineering;Growth;Habitats;Human;human disease;human pathogen;Immune;Immune response;Immunity;Immunization Programs;immunogenic;immunogenicity;In Vitro;in vivo;Individual;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Injections;Laboratory Study;Lassa virus;mathematical model;mathematical theory;Methodology;Modeling;Murid herpesvirus 1;Mus;new technology;novel;novel strategies;pandemic disease;pathogen;pathogen spillover;Pattern;Penetration;Performance;Persons;Play;Population;predictive modeling;pressure;prevent;Prevention;Procedures;Process;programs;Property;prototype;Rabies;Rodent;Role;Severe Acute Respiratory Syndrome;Source;superinfection;Technology;trait;Transgenes;transmission process;Vaccinated;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine distribution;vaccine evaluation;Vaccines;Validation;vector;Vertebral column;Viral;Virus;Wild Animals;Work;Zoonoses

PROJECT_TITLE: A Mathematical Theory of Transmissible Vaccines

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: We propose to conduct a randomized controlled trial to test two different financial incentive programs (versus control) to promote physical activity among 330 low-active adults. One incentive program will replicate a program currently used by three major health insurance programs in the absence of empirical support: Participants will have the opportunity to earn a refund of $200 for attending at least 50 sessions over 6 months. The other incentive program will have the same incentive schedule, but will use a “loss-frame”, such that participants are told that $200 of their membership fee is being held and will be returned or forfeited depending on whether they use the gym at least 50 times in the next 6 months.

PI_NAMEs: GALARRAGA, OMAR ;WILLIAMS, DAVID M (contact)

PROGRAM_OFFICER_NAME: HALL, KARA L

PROJECT_TERMS: Accelerometer;Adherence;Adult;Age;alcohol abuse therapy;Behavior;behavior change;Body Weight decreased;Cardiovascular Diseases;Colon;community setting;cost;cost per quality-adjusted life year;cost utility analysis;Data;Diabetes Mellitus;Dropout;economic impact;economic incentive;efficacy evaluation;energy balance;Enrollment;Exercise;exercise program;Fees;financial incentive;fitness;Frequencies;Funding;Future;Guidelines;Habits;Health;Health Benefit;Health Insurance;Healthcare;Household;improved;incentive program;Incentives;Income;incremental cost;innovation;Insurance;Intervention;labor force participation;Low income;Malignant Breast Neoplasm;Mediating;Mediator;medication compliance;Modeling;moderate-to-vigorous physical activity;mortality;Negative Reinforcements;Outcome;Participant;Patient Self-Report;Pharmacotherapy;Physical activity;Physical assessment;Pilot Projects;primary outcome;Productivity;programs;Provider;Psychological reinforcement;randomized trial;Randomized, Controlled Trials;Regrets;Reinforcement Schedule;Research;Research Support;Risk;Schedule;secondary outcome;sexual risk behavior;smoking cessation;Swimming;systematic review;Taxes;Testing;theories;Training;Visit

PROJECT_TITLE: Empirical testing of a widely available insurance-based monetary incentive program for exercise: A randomized trial

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: The clinical and economic costs of mental illness are significant within the VA. For example, ~4% of veterans suffer from schizophrenia, ~8-31% suffer from PTSD, and ~7-18% suffer from a substance use disorder. Currently available treatments for these disorders are insufficiently effective, are often costly, time-consuming, and associated with significant side-effects, and frequently have poor uptake and adherence. Most mental illnesses are associated with social deficits that lead to social isolation and loneliness, which in turn lead to worse mental and physical outcomes including suicide, despair, and early mortality. Using a multidisciplinary and multi-pronged transdiagnostic approach, my lab is focused on understanding and treating the pathological psychological, neural, and behavioral mechanisms of these social deficits. We hope that by targeting these deficits with novel pharmacological and non-pharmacological interventions, we can revolutionize mental illness treatment within the VA, leading to better clinical outcomes and decreased health care costs.

PI_NAMEs: WOOLLEY, JOSH  (contact)

PROJECT_TERMS: Acceleration;Acute;Adherence;Affect;Agonist;alcohol use disorder;Area;attentional bias;Award;Behavior;Behavioral;Behavioral Mechanisms;Caring;Cellular Phone;Chronic;Clinical;clinical application;Clinical Trials;Cognitive;cognitive ability;cohesion;comorbidity;Consumption;cost;craving;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;disability;Disease;Doctor of Philosophy;doctoral student;economic cost;ecstasy;effective therapy;efficacy trial;Emotions;Epidemic;Eye;Face;Faculty;Feeling;Focus Groups;Funding;gaze;Goals;graduate student;Health;Health Care Costs;Health system;Healthcare;improved;Individual;Industry;Interdisciplinary Study;International;Intervention;K-Series Research Career Programs;Laboratories;Lead;Loneliness;Measures;Medical;Medical Students;member;Mental disorders;Mental Health;Mentors;Mission;Modification;Morbidity - disease rate;mortality;Motivation;multidisciplinary;neural;neuroimaging;neuromechanism;Neuropeptides;neurophysiology;neuropsychiatric disorder;Nonpharmacologic Therapy;novel;Occupational;opioid use disorder;Outcome;Oxytocin;Pathologic;Pathway interactions;Patients;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;physical conditioning;Physiological;Positioning Attribute;Post-Traumatic Stress Disorders;Postdoctoral Fellow;pre-doctoral;Prevalence;Privatization;Productivity;program costs;programs;Psilocybin;Psyche structure;Psychiatric therapeutic procedure;psychologic;Psychophysiology;Psychoses;psychosocial;Psychotherapy;Quality of life;randomized, clinical trials;receptor;reduce symptoms;Reporting;Research;Research Assistant;Research Personnel;Schizophrenia;Scientist;service utilization;Services;Severities;Short-Term Memory;side effect;Site;smartphone application;social;Social Behavior;social cognition;social deficits;Social Functioning;Social isolation;Social Processes;social situation;Social support;stimulant use disorder;Substance Use Disorder;Suicide;Talents;Testing;Time;Training;Transition Career Development Award (K22);treatment program;United States National Institutes of Health;uptake;Veterans;volunteer;Work

PROJECT_TITLE: CSR&D Research Career Development Transition Award Application


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Schizophrenia is a severe mental illness with major public health consequences for Veterans. Treatment of Veterans with schizophrenia in the VA health system accounts for a disproportionately large amount of the VA’s total health care budget (16-20%). Schizophrenia is the most expensive per patient psychiatric condition within the VA, with the majority of affected Veterans receiving some level of service connection. Pharmacological advances have helped to alleviate acute psychotic symptoms, such as hallucinations and delusions. However, current interventions are not sufficient to improve recovery and adaptive functioning, particularly in the social domain. The proposed study aims to systematically evaluate components of social motivation and their respective stages of processing to assess their influence on real-world social functioning. This knowledge can inform novel interventions that target the specific aspects of social motivation that are most disrupted in Veterans with schizophrenia.

PI_NAMEs: CATALANO, LAUREN THERESA (contact)

PROJECT_TERMS: Acute;Address;Affect;Area;Attention;Award;Budgets;California;career;Cellular Phone;clinical center;Community Integration;Consensus;cost;Cues;Delusions;Detection;digital phenotyping;Disabilities experience;Disease;Doctor of Philosophy;Ecological momentary assessment;Education;Electroencephalography;Environment;Event-Related Potentials;Evidence based treatment;experience;Functional impairment;Global Positioning System;Goals;Grain;Hallucinations;Health system;Healthcare;Healthcare Systems;Home;Homelessness;Human;Impairment;improved;indexing;Infrastructure;innovation;Interpersonal Relations;Intervention;Interview;K-Series Research Career Programs;Knowledge;Los Angeles;Measures;member;Memory;memory encoding;memory recognition;memory retrieval;Mental disorders;Mentors;Methodology;Methods;Modernization;Motivation;multimodality;National Institute of Mental Health;neural;novel;Patient Self-Report;Patients;Pattern;pharmacologic;phenotypic data;preference;Process;programs;Psychology;psychotic symptoms;Public Health;Recovery;Reporting;Research;Research Domain Criteria;Research Personnel;Retrieval;Schizophrenia;Services;severe mental illness;smartphone based assessment;social;social attention;Social disability;Social Functioning;social influence;Social Interaction;social learning;social neuroscience;Specificity;Stimulus;sustained attention;Techniques;Technology;temporal measurement;therapy development;Time;Training;Translational Research;treatment center;United States National Institutes of Health;Universities;Veterans;Work

PROJECT_TITLE: Approaches to Studying Social Motivation in Schizophrenia


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.

PI_NAMEs: BOERCKEL, JOEL D (contact)

PROJECT_TERMS: 3T3 Cells;Actins;Actomyosin;Animals;Behavior;Benchmarking;Biological Assay;Biology;Biophysics;Cell Line;Cell membrane;cell motility;cell type;Cells;Cellular Morphology;Collaborations;Cytoskeleton;Decision Making;density;Dependence;Development;Dimensions;Dissection;Dominant-Negative Mutation;empowerment;Engineering;Equilibrium;experimental study;Extracellular Matrix;F-Actin;Family;Feedback;flexibility;Focal Adhesions;Future;Gene Expression;Generations;Genetic;genetic payload;Genetic Transcription;Goals;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterodimerization;Heterogeneity;Homeostasis;Human;Image;innovation;insight;Intercellular Junctions;Light;Link;Lipids;loss of function;Maps;Measures;mechanical force;mechanical stimulus;mechanotransduction;member;Membrane;Membrane Proteins;mesenchymal stromal cell;Metabolic;Metabolic stress;Methods;Microscopy;migration;Molecular;Monomeric GTP-Binding Proteins;Motility;Natural regeneration;Nodal;novel;operation;Optics;optogenetics;Outcome;Output;Pattern;Performance;Peripheral;Pharmacology;Photoreceptors;Physiological;polymerization;Polymers;Population;Productivity;Proliferating;Proteins;Qualifying;recruit;Regulation;Reporter;Reporting;research and development;Resolution;Resources;response;rho;Role;Signal Transduction;Spatial Distribution;spatial integration;spatiotemporal;Spectrum Analysis;Stress Fibers;Techniques;Technology;Testing;Tissues;tool;Traction;transmission process;Visualization;Zebrafish

PROJECT_TITLE: Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key autonomic systems: the autonomic nervous system, the cardiovascular system, the immune system, and metabolic system. This research will produce a first-in-the-world dataset that will be foundational for the development of VNS-based therapies for several maladies related to autonomic systems.

PI_NAMEs: EBERLY, LYNN E;IKRAMUDDIN, SAYEED ;LIM, HUBERT HYUNGIL;MACEFIELD, VAUGHAN GARY;NAHAS, ZIAD ;OSBORN, JOHN W (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Academia;Advocate;Anatomy;Anxiety Disorders;Autonomic nervous system;Big Data;biophysical model;Budgets;Cardiovascular system;Clinical;Clinical Data;Clinical Research;clinical research site;Clinical Trials Data Monitoring Committees;Communication;Data;data ecosystem;data modeling;Data Set;Development;Devices;Electric Stimulation;Ensure;Epilepsy;experience;Future;Gastrointestinal Diseases;Goals;Human;Human Resources;Immune;Immune system;Implant;Industry;Institution;Medical;meetings;Mental Depression;Metabolic;Metabolism;Multi-Institutional Clinical Trial;multidisciplinary;Nerve;Nervous System Physiology;neuroregulation;novel therapeutics;Organ;Outcome;Patients;Physiological;Physiology;predictive modeling;Productivity;programs;Protocols documentation;Research;Research Design;Research Personnel;response;System;technology research and development;Therapeutic;therapeutic development;United States National Institutes of Health;Vagus nerve structure;Work

PROJECT_TITLE: REVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages.


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Race-related traumatic online experiences have become daily stressors in the lives of adolescents of color, yet media literacy programs fail to help young people manage these challenges. We propose to address this need with the design, development, and evaluation of an immersive virtual reality (VR), media literacy, and coping skills intervention. Guided by a media literacy as health promotion and prevention framework and culturally responsive computing theory, the VR intervention will build on Black and Latinx adolescents’ strengths and provide immersive practice to enhance the learning of coping skills and racial coping self-efficacy for dealing with negative race-related digital media.

PI_NAMEs: TYNES, BRENDESHA MARIE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 19 year old;access disparities;Address;Adolescent;Anxiety;Automobile Driving;Award;Black race;Buffers;Child;Color;Communities;coping;Coping Skills;Coupling;COVID-19 pandemic;Critiques;depressive symptoms;design;Development;digital;digital media;Discrimination;disinformation;disparity reduction;Distance Learning;Education;Effectiveness;Ensure;Environment;Evaluation;Exclusion;experience;Feeling suicidal;Future;Genocides;health equity;Health Promotion;Image;innovation;insight;Intelligence;Internet;Intervention;laptop;Latinx;Learning;lens;literacy;Literacy Programs;Mental Depression;Mental Health;Mental Health Services;Modeling;Outcome;Participant;people of color;Persons;Post-Traumatic Stress Disorders;Preparation;Prevention;preventive intervention;psychoeducation;Published Comment;Race;racial discrimination;racism;Randomized, Controlled Trials;Reporting;Research;rumination;Sampling;Schools;Self Efficacy;Shapes;skills;Social Interaction;social stigma;Stigmatization;stressor;Students;substance use;Symptoms;teacher;Telephone;theories;Therapeutic;Training;underserved community;virtual;virtual reality;virtual reality environment;virtual reality intervention;Youth

PROJECT_TITLE: Using Immersive Virtual Reality and Media Literacy to Enhance Adolescents' Coping Skills in the Face of Traumatic Online Experiences


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: OSBORN, JOHN W (contact)

PROJECT_TERMS: Advocate;Anatomy;Autonomic nervous system;Budgets;Calendar;Cardiovascular system;Clinical;Clinical Research;Clinical Trials Design;Collaborations;Communication;Complex;Contracts;Data;data exchange;Ensure;Event;experience;Feedback;Future;Goals;Head;Health Insurance Portability and Accountability Act;Human Resources;Immune system;Institution;interest;journal article;Link;Medical;meetings;member;Metabolic;metabolomics;Minnesota;multidisciplinary;Nerve;neuroregulation;Newsletter;Operative Surgical Procedures;participant enrollment;Patients;payment;Productivity;Reporting;Research;Research Personnel;Scientist;Secure;Surgeon;System;therapy design;Transfer Agreement;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


PI_NAMEs: NAHAS, ZIAD  (contact)

PROJECT_TERMS: Acceleration;Acute;Adipose tissue;Anatomy;Animal Model;Australia;Autonomic nervous system;autonomic reflex;Baroreflex;Blood Pressure;C-reactive protein;Caliber;Cardiac;Cardiovascular system;Cell Count;Cervical;Chronic;Clinic;Clinical;clinical biomarkers;clinical efficacy;Clinical Research;Communities;cytokine;Data;Data Set;Dependence;design;Development;Devices;Echocardiography;Electric Stimulation;Electrocardiogram;Ensure;Epilepsy;Fiber;Frequencies;Gastric Emptying;Glucagon;Glucose;Glycosylated hemoglobin A;Goals;Heart Rate;Hormones;Hospitals;Human;Immune;Immune system;Implant;improved;in vivo;Insulin;Knowledge;Late Effects;Lipids;Literature;machine learning method;Maps;Measurement;Measures;Mechanics;Medical;Medical Device;meetings;Mental Depression;Metabolic;metabolomics;Minnesota;Nerve;Nervous System control;Neurosciences;novel;novel therapeutics;Operative Surgical Procedures;Organ;Otolaryngology;Outcome;Outcome Measure;Output;Participant;patient safety;patient subsets;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phase;Physiologic pulse;Physiological;post stroke;Protocols documentation;Quality Control;recruit;Research;Research Design;respiratory;Role;Serum;Sinus;Site;South Carolina;Specific qualifier value;Statistical Data Interpretation;Stimulus;stressor;stroke recovery;System;Testing;therapeutic development;Time;Titrations;TNF gene;vagus nerve stimulation;Vagus nerve structure;Visit;Washington;Width

PROJECT_TITLE: Clinical Core


PI_NAMEs: JOHNSON, MATTHEW DOUGLAS (contact)

PROJECT_TERMS: Acute;Affect;Anatomy;Australia;Autonomic nervous system;Award;Big Data;Biometry;biophysical model;Biophysics;Blood Pressure;Cardiovascular Physiology;Cardiovascular system;Cervical;Chronic;Clinic;Clinical;clinical research site;Collaborations;Communities;cytokine;Data;Data Collection;data ecosystem;data modeling;Data Set;data visualization;design;Development;Devices;Ensure;Epilepsy;experience;Experimental Designs;Fiber;Foundations;Generations;Goals;Health;Heart Rate;Hospitals;Human;Immune;Immune system;Implant;industry partner;Inflammatory;inflammatory marker;Knowledge;Late Effects;Location;Medical;meetings;Mental Depression;Metabolic;metabolomics;Minnesota;Modeling;Monitor;Muscle;Nerve;neural model;Neurosciences;novel;Outcome Measure;Participant;Patients;Peripheral;Physiology;predictive modeling;Process;prospective;Protocols documentation;recruit;Research;research and development;Research Contracts;Research Design;Research Personnel;Resources;response;Secure;simulation;Site;South Carolina;Specific qualifier value;Statistical Data Interpretation;Supercomputing;System;Techniques;Testing;therapeutic development;Time;TNF gene;tool;Universities;Vagus nerve structure;Visualization;Visualization software;Washington;Work

PROJECT_TITLE: Data and Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The proposed research is directly relevant to public health because it will reveal key developmentally-regulated neural circuit mechanisms that render the maturation of the prefrontal cortex vulnerable to the detrimental impact of cannabis during adolescence. This goal is directly aligned with the NIDA agenda by delineating a developmental framework in which substance use disorders-associated behavioral deficits can be understood, specifically those arising during the adolescent transition to adulthood. This knowledge is expected to fully serve NIH-NIDA mission by devising timing-sensitive intervention strategies to prevent or mitigate the onset of substance use/abuse during critical periods.

PI_NAMEs: TSENG, KUEI-YUAN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affective;Age;age related;Attenuated;Automobile Driving;Behavior;Behavior Control;Behavioral;behavioral response;Calibration;Cannabis;Cannabis Abuse;CNR1 gene;Cognitive;Cognitive deficits;cognitive reappraisal;critical period;Data;designer receptors exclusively activated by designer drugs;Development;Developmental Process;Disinhibition;Electrophysiology (science);emotion dysregulation;emotion regulation;epidemiology study;Equilibrium;Exposure to;fear memory;gamma-Aminobutyric Acid;Glutamates;Goals;Hippocampus;Human;Impairment;in vivo;Infusion procedures;interest;Intervention;Knowledge;Life;Link;Mediating;Mission;National Institute of Drug Abuse;neural circuit;Neurobiology;neuronal circuitry;postnatal;Predisposition;preference;Prefrontal Cortex;prevent;Process;Public Health;Rattus;Research;Risk;Signal Transduction;Smoking;substance use;Substance Use Disorder;Sucrose;Synapses;Testing;Tetrahydrocannabinol;THC exposure;transition to adulthood;transmission process;United States National Institutes of Health;vulnerable adolescent

PROJECT_TITLE: Impact of Cannabis on Prefrontal Maturation

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


PI_NAMEs: MACEFIELD, VAUGHAN GARY (contact)

PROJECT_TERMS: Abdomen;Affect;Anatomy;Anxiety Disorders;Autonomic nervous system;awake;Axon;Blood Pressure;Body System;carbon fiber;Cardiac;Chest;Chronic;Clinical;Clinical Research;Common Core;Cranial Nerves;Data;Development;Devices;Distal;Electrodes;Epilepsy;Fascicle;Fiber;flexibility;Frequencies;Future;Gastrointestinal Diseases;Gastrointestinal tract structure;Heart;heart rate variability;Human;Implant;Implanted Electrodes;Intractable Epilepsy;Investigation;Italy;Lung;Measures;Mental Depression;Metals;Microelectrodes;Morphology;Motor;motor control;Muscle;Myelinated nerve fiber;Neck;Nerve;Nerve Fibers;nerve supply;neural;neurophysiology;novel;operation;Operative Surgical Procedures;Organ;organ growth;Outcome;Paper;Parasympathetic Nervous System;Participant;Patients;Phase;Physiologic pulse;Physiology;Protocols documentation;Publishing;Randomized;Rattus;recruit;Report (document);Reporting;Research;respiratory;Running;Sensory;Sensory Physiology;Series;Site;Skin;Source;Specific qualifier value;Stimulus;Structure;Sympathetic Nervous System;Titrations;tool;Training;ultrasound;Unmyelinated Nerve Fibers;Vagus nerve structure;Visceral;Width;Work

PROJECT_TITLE: Microelectrode Recordings from the Vagus Nerve in Awake Humans


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Rehabilitation

ORG_CITY: Broomfield

ORG_NAME: POINT DESIGNS, LLC

ORG_STATE: CO

PHR: PROJECT NARRATIVE Approximately 600,000 people live with partial hand amputations in the United States. We are developing a new type of finger prosthesis for these individuals. This proposal enables completion of the work required for regulatory clearance of the device.

PI_NAMEs: KALIKI, RAHUL REDDY;SLIKER, LEVIN  (contact);WEIR, RICHARD FERGUS FFRENCH

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: 3D Print;actigraphy;Address;Amputation;Amputees;Anatomy;Bilateral;Clinic;clinic ready;Clinical;Clinical assessments;Clinical Research;Clinical Trials;commercialization;Computer software;design;Development;Devices;Digit structure;Electrodes;Electromagnetics;Electromyography;Electronics;Employment;empowerment;Engineering;Ensure;Environment;experience;fabrication;Failure;Fingers;flexibility;Focus Groups;Foundations;functional improvement;Future;Goals;graphical user interface;Hand;Home;Home environment;improved;Individual;Industry;Instruction;Joints;Laboratories;Light;limb loss;Lithium;Marketing;Measurement;Measures;Mechanics;Medical;Medical Device;Medical Electronics;men;Metacarpophalangeal joint structure;Methods;miniaturized device;Motor;myoelectric control;Myoelectric prosthesis;Outcome Measure;Output;Participant;patient population;Patients;Performance;Persons;Phase;Polymers;powered prosthesis;Preparation;primary outcome;Production;professional atmosphere;Prosthesis;prosthetic hand;prototype;psychologic;Quality of life;recruit;Rotation;Safety;Small Business Innovation Research Grant;Software Design;Solid;Specific qualifier value;Speed;standard of care;System;Testing;Time;Titanium;United States;Upper Extremity;Validation;verification and validation;Water;Woman;Work

PROJECT_TITLE: Development and clinical assessment of a robust, 3D printed titanium, myoelectric powered prosthetic digit system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(10)B]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Digestive Diseases;Neurosciences;Rehabilitation

PI_NAMEs: CAMILLERI, MICHAEL L. (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Anatomy;Autonomic nervous system disorders;Black Box;Cardiovascular Diseases;Cervical;cholinergic;Chronic;Clinic;Clinical;Clinical Research;cohort;comorbidity;Data;Disease;Dyspepsia;effective therapy;egg;Electric Stimulation;Emergency department visit;Epilepsy;Face;Fasting;Fatty acid glycerol esters;FDA approved;Foundations;Frequencies;Future;Gastric Emptying;Gastrointestinal Diseases;gastrointestinal symptom;Gastroparesis;Generations;Goals;Heart;Heart failure;High Prevalence;Hospitalization;hospitalization rates;Image;Immune System Diseases;Implant;improved;Incidence;Inflammation;Ingestion;innovation;insight;intravenous injection;Left;Measurement;Measures;Mediating;meetings;Mental Depression;Metabolic Diseases;Methods;Metoclopramide;Minnesota;mortality;Motor;motor disorder;Movement;Movement Disorders;Muscle;nerve supply;Neurons;Nitrogen;novel;Obesity;open label;Operative Surgical Procedures;Organ;Patients;Peripheral;Persons;Pharmaceutical Preparations;Physiologic pulse;Population;post stroke;Prevalence;primary endpoint;Protocols documentation;Radiolabeled;Reporting;Research;response;Review Literature;Risk;Sensory;single photon emission computed tomography;sleep pattern;Solid;Stomach;stroke recovery;Symptoms;systematic review;Tardive Dyskinesia;Testing;Time;type I and type II diabetes;Universities;vagus nerve stimulation;Vagus nerve structure;Width;Women's prevalence;Work

PROJECT_TITLE: Effect of VNS on Gastric Motor Functions


PROJECT_TERMS: Acute;Anatomy;Ancillary Study;Animal Model;Autonomic nervous system;autonomic reflex;Body System;Brain;Cardiac;Cardiovascular system;Cervical;Chronic;Clinic;Clinical;Clinical Research;Communities;Complement;Coupled;Data;Data Set;depressed patient;design;Devices;Electrophysiology (science);Ensure;Epilepsy;experience;Frequencies;Future;glucose metabolism;Hospitals;Human;Immune;immune function;Implant;lipid metabolism;machine learning method;Measures;Mechanics;Medical;Medical Device;meetings;Mental Depression;Metabolic;Minnesota;multidisciplinary;Muscle;Nerve;Nervous System control;Neurosciences;novel;Operative Surgical Procedures;Organ;Otolaryngology;Outcome;Outcome Measure;Participant;patient safety;Patients;Peripheral;Phase;Physiologic pulse;Physiological;Physiology;post stroke;pressure;Protocols documentation;Qualifying;recruit;Research;Research Contracts;Research Design;Research Personnel;Resources;response;Site;South Carolina;Statistical Data Interpretation;stroke recovery;System;Testing;Universities;vagus nerve stimulation;Vagus nerve structure;Visit;Washington

PROJECT_TITLE: VNS Modulation of the Central Autonomic Network and its Effects on ANS


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE  The two largest primary risk factors for late onset Alzheimer’s Disease (AD) are aging and APOE4 genotype. This project tests the efficacy of the longevity promoting intervention, 17α-estradiol, on aging- associated APOE4 phenotypes and AD development. This study is crucial to understand how geroscience and longevity-promoting interventions can be used to alleviate APOE4-associated risk for AD progression.

PI_NAMEs: MCGILL, CASSANDRA JOAN (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Affect;Age;Age Months;age related;aged;Aging;aging process;aging related;aging related disease;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Biochemistry;blood glucose regulation;Body Weight;C57BL/6 Mouse;Cognition;comparison intervention;Coupled;Data;Development;disease phenotype;Disease Progression;drug development;Early Onset Alzheimer Disease;effective therapy;efficacy testing;Estradiol;estrogenic;Evaluation;Event;Exhibits;experience;extend lifespan;Fatty Liver;Female;frailty;Genotype;Geroscience;Gliosis;Goals;Health;healthspan;Human;Immunohistochemistry;Impairment;improved;improved outcome;Inflammation;Inflammatory;Intervention;Knock-in;Knock-in Mouse;Late Onset Alzheimer Disease;Learning;Leptin;life span;Link;lipidomics;Longevity;male;Measures;Memory;Metabolic;Metabolic dysfunction;middle age;Midlife women;Modeling;mouse model;multiple omics;Mus;neural;Neural Pathways;neurogenesis;neuroinflammation;neuronal survival;Obesity;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peripheral;permissiveness;Pharmaceutical Preparations;Phenotype;Placebos;Plasma;prevent;Prevention therapy;programs;Regulation;Risk Factors;Role;screening;Senile Plaques;sex;stem;targeted treatment;tau aggregation;Testing;Therapeutic;therapeutic candidate;transcriptomics;Transgenes;Variant;Wild Type Mouse

PROJECT_TITLE: 17 alpha-estradiol as a potential protective therapeutic against development of Alzheimer's disease


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE Computer-based modeling, simulation, and visualization of molecular systems have evolved as indispensable tools for modern science and medicine. Over the past three decades, the NIH Resource at Illinois has provided some of the most advanced and widely used (currently with more than 125,000 users) software packages that make computational tools and algorithms for molecular and cell modeling readily and freely available to the biomedical community. Beyond developing computational technology driven by the needs of its very large user base, the Resource is engaged in training activities supported by an unparalleled number of fully online and heavily used set of tutorials, case studies, workshops, and a heavily visited web site.

PI_NAMEs: TAJKHORSHID, EMAD  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Algorithms;Area;Automation;base;Bioinformatics;Biological;Biomedical Research;biomedical scientist;Biomedical Technology;Case Study;Cell model;Cells;Cloud Computing;Code;Collection;Communities;community engagement;Computational algorithm;computational platform;Computer Models;Computer software;computerized tools;Consumption;cost;COVID-19;Cryoelectron Microscopy;cyber security;Data Collection;data quality;Documentation;Education;Educational workshop;Emerging Technologies;empowerment;Ensure;experience;Free Energy;Funding;Genome;Goals;Illinois;Image;improved;Individual;Industry;Institution;Internet;interoperability;Knowledge;laptop;large datasets;Ligands;Mainstreaming;Medicine;Membrane;Membrane Proteins;Methods;Mission;Modeling;models and simulation;Modernization;Molecular;molecular modeling;Monitor;National Center for Research Resources;National Institute of General Medical Sciences;online tutorial;operation;outreach;Performance;Plug-in;Positioning Attribute;Prize;Procedures;programs;Protein Dynamics;R24;Reproducibility;Research;Research Personnel;Resources;Running;Sampling;Science;Scientist;screening;Services;simulation;software development;Software Tools;Structural Biologist;structural biology;supercomputer;Supercomputing;Surveys;System;Techniques;Technology;Time;tool;Training;Training Activity;Training Programs;Update;user friendly software;Vendor;Visit;Visualization;web server;web site;Work;Writing

PROJECT_TITLE: Resource for Macromolecular Modeling and Visualization


ORG_CITY: RENO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative The goal of this project is to develop a series of techniques to profile post-translational modification (PTM)- based regulation of protein function. In particular, we intend to measure PTM-mediated alterations in protein higher-order conformation. This is related to human health as the dysregulation of these processes is highly correlated with disease and detailed knowledge of these conformations can inform drug discovery.

PI_NAMEs: BOROTTO, NICHOLAS BRENT (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acceleration;Adoption;Automobile Driving;Biological;Cardiovascular Diseases;Cell Physiology;Chemicals;complex biological systems;Derivation procedure;design;diagnostic value;Digestion;Disease;Distal;drug development;drug discovery;Ensure;Goals;Health;Higher Order Chromatin Structure;Human;improved;insight;ion mobility;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Methods;Modeling;Molecular Conformation;Nature;Neurodegenerative Disorders;new technology;new therapeutic target;Peptides;Post-Translational Protein Processing;Process;protein function;Proteins;Proteomics;Reagent;Regulation;Reporting;Reproducibility;Research Proposals;Sampling;Series;Spectrometry;System;Techniques;Therapeutic Intervention;tool

PROJECT_TITLE: Rapid Assessment of Proteoform-Resolved Higher-Order Structures


NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed work seeks to characterize the metabolic footprint of commensal Clostridia and investigate how this contributes to their microbial assembly in the gut. Completion of the proposed work provides fundamental knowledge about prevalent yet under-characterized human gut commensals and their role in human health and disease, all of which advance our ability to manipulate the gut microbiota for our benefit.

PI_NAMEs: SEEKATZ, ANNA MARIA (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Niche Partitioning of Commensal Clostridia in the Gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Intracortical brain-computer interfaces (iBCIs) have been used to restore movement to humans with spinal cord injury, but users have control only of the motion of the arm and hand, not its stiffness, nor forces applied to grasped objects. We propose to circumvent this fundamental limitation by developing an iBCI for humans that effects movement by predicting patterns of muscle activity, used as inputs to a musculoskeletal model of the hand. We have proposed to develop the system initially in virtual reality, then test it with a robotic limb; it could also be used to reanimate a person's own paralyzed limb through functional electrical stimulation of muscles or nerves.

PI_NAMEs: COLLINGER, JENNIFER L.;HATSOPOULOS, NICHOLAS G;MILLER, LEE  (contact);MURRAY, WENDY M

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Area;arm;arm movement;Attention;Biomimetics;brain computer interface;brain surgery;Complex;Data;design;Development;Devices;dexterity;Digit structure;electric impedance;Feedback;finger movement;Fingers;functional electrical stimulation;grasp;Hand;Hand functions;high dimensionality;Human;improved;Individual;Intuition;joint stiffness;Joints;kinematics;Kinetics;Leg;Life;limb loss;Limb structure;Maps;Measurement;Measures;Methods;microstimulation;Modeling;Monkeys;Motion;Motor;motor control;Motor Cortex;Motor output;Movement;Muscle;Musculoskeletal;Nerve;neuromuscular system;Neurons;novel;Output;Paralysed;Participant;Patients;Pattern;Performance;Persons;Physics;Posture;Quadriplegia;robot control;Robotics;Role;Shapes;Signal Transduction;Somatosensory Cortex;Spinal cord injury;System;Tactile;Testing;Time;Touch sensation;Training;User-Computer Interface;virtual reality;virtual reality environment;Visualization

PROJECT_TITLE: Development of an EMG-controlled BCI for biomimetic control of hand movement in humans

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Alzheimer’s disease (AD) is the most common form of dementia diagnosed through the presence of brain amyloid beta (Aβ) plaques, generated from amyloid precursor protein (APP). APP and Aβ localize to mitochondria and mitochondrial associated membranes (MAMs). We will test the hypothesis that the cellular localization of APP at mitochondria and MAMs dictates Aβ production.

PI_NAMEs: STROPE, TAYLOR A. (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Abeta synthesis;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Area;Astrocytes;Award;beta secretase;Bioenergetics;Biological Assay;Biology;Brain;calcium metabolism;career;Career Choice;cell type;Centrifugation;Cholesterol Esters;Cholesterol Homeostasis;CRISPR/Cas technology;Data;Dementia;design;Diagnosis;Electron Microscopy;Endoplasmic Reticulum;Environment;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;Fellowship;Functional disorder;Generations;genome editing;Goals;Grant;human induced pluripotent stem cells;Impairment;In Situ;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;Integral Membrane Protein;Kansas;Ligation;Medical center;Membrane;membrane activity;membrane assembly;Mentors;Methods;Mitochondria;mitochondrial metabolism;Modality;Mutation;Neurofibrillary Tangles;Neurons;new therapeutic target;non-demented;novel;Oxidative Stress;Pathologic;Phospholipid Metabolism;Phospholipids;Postdoctoral Fellow;Production;Research;Role;Sampling;Site;stem cell model;tau Proteins;Testing;Training;Universities;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Interactions between Mitochondria, ER, and Amyloid


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Deep proteomic and metabolomic profiling of biological tissues is an overarching goal of modern biological and biomedical research, but it remains a key – and conspicuous – missing component from the spectrum of -omics, specifically genomics and transcriptomics, which capitalize on next-generation sequencing of DNA and RNA. The proposed effort will meet this challenge by advancing revolutionary new methods for label-free single- molecule proteomic and metabolomic profiling, combining them with novel methods for sub-cellular spatial analysis. Its achievement will complete the constellation of single-cell -omics, thereby broadly advancing research worldwide in fields that span from fundamental biology to the frontiers of clinical medicine.

PI_NAMEs: ROUKES, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Achievement;Biological;biological research;Biology;Biomedical Research;Cell Physiology;Cells;Clinical Medicine;Complex;Computer software;Detection;Disease;DNA sequencing;frontier;Gene Expression Regulation;genomic tools;Genomics;Goals;high throughput technology;Human;Image;Individual;innovation;insight;Instruction;instrumentation;ionization;Knowledge;Label;Machine Learning;Mammalian Cell;Maps;mass spectrometer;Mass Spectrum Analysis;metabolome;metabolomics;Methodology;Methods;microsensor;miniaturized sensor;Modernization;nanoscale;nanosensors;Nanotechnology;next generation;next generation sequencing;novel;Onset of illness;Organism;Post-Translational Protein Processing;Protein Analysis;Proteins;Proteome;Proteomics;Research;Resolution;response;RNA;Sampling;sensor;sensor technology;Serum;Signal Transduction;single molecule;Stimulus;Stress;success;Surface;System;Techniques;Technology;Tissue Sample;Tissues;transcriptomics;Vacuum

PROJECT_TITLE: Next-generation spatial -omics: High-throughput, single-molecule proteomic imaging with subcellular resolution


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision

ORG_CITY: COLUMBIA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Sjögren’s syndrome, an autoimmune disease characterized by uncontrolled inflammation, impairs saliva production and leads to severe and chronic dryness in the oral cavity. We propose to determine the role of tuft cells, a type of cell that has been found to be important for proper immune functioning in other organs, for the proper immune functioning of salivary glands in healthy patients and those with Sjögren’s syndrome. These studies are expected to introduce a new area of investigation to salivary gland research and potentially lead to novel treatment options.

PI_NAMEs: TAVARES DOS SANTOS, HARIM  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Ablation;adaptive immune response;adaptive immunity;Affect;airway epithelium;alpha-gustducin;Area;Autoimmune Diseases;Binding;Biological;Cell Lineage;Cell Physiology;cell type;Cells;Cellular biology;cellular microvillus;Cellular Structures;cholinergic;Chronic;Coupled;cytokine;defense response;design;Detection;Development;Disease;Dryness;Eicosanoids;Electron Microscopy;Epithelial Cells;Epithelium;Exhibits;Exocrine Glands;experimental study;Exposure to;Family;follow-up;Follow-Up Studies;Foundations;G-Protein-Coupled Receptors;gastrointestinal epithelium;Generations;Genes;Helper-Inducer T-Lymphocyte;Homeobox;Host Defense;Human;IL17 gene;Immune;immune function;Immune response;Immune signaling;immune system function;Immunity;immunoregulation;Impairment;in vivo;in vivo Model;Inflammation;Inflammatory;innate immune function;Innate Immune Response;insight;Interleukin-13;interleukin-17E;Interleukin-4;Interleukin-5;Interleukins;Intestines;Investigation;Laboratories;Lipopolysaccharides;Literature;Lymphocytic Infiltrate;Mediating;member;Mentors;Mentorship;Microscopic;Microscopy;Minor salivary gland structure;Modernization;Molecular Biology;Molecular Immunology;mouse model;Mus;Natural Immunity;Neurotransmitters;neutralizing antibody;novel;Oral cavity;Organ;pathogen;Pathogenesis;Pathway interactions;Patients;Phase;Phospholipase;Play;Principal Investigator;Production;programs;Proteins;Rattus;receptor;Receptor Signaling;receptor-mediated signaling;Research;Research Personnel;Resolution;response;Role;Saliva;Salivary Gland Diseases;Salivary Glands;Sensory;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;Sjogren's Syndrome;Source;Specimen;Structure;Submandibular gland;Taste Buds;Techniques;Technology;therapeutic target;Time;Tissues;Training;transcription factor;transcriptomics;TRPM5 gene;Work

PROJECT_TITLE: The Role of Tufts Cells in Salivary Gland Immunity


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Women who experience gestational diabetes are at high risk of developing type 2 diabetes mellitus in the postpartum period – especially in low- and middle-income countries like India where the burden of diabetes is high and disproportionately affects women – but few receive the World Health Organization-recommended postpartum diabetes screening. We propose a hybrid type II effectiveness-implementation cluster randomized trial, guided by the CFIR Framework, to determine whether community health workers can improve postpartum diabetes screening in the urban slums of Pune, India, through home-based testing or clinic-based referral with regular reminders. The proposed study seeks to provide an acceptable and scalable model to improve postpartum diabetes screening in other low-income settings, thereby improving early detection of diabetes in women and preventing morbidity and mortality in this high-risk population.

PI_NAMEs: MATHAD, JYOTI S;SUNDARARAJAN, RADHIKA LU (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: adverse outcome;antenatal;arm;Cardiovascular Diseases;Caring;Cause of Death;Chronic Disease;Clinic;Clinical;clinical care;Cluster randomized trial;Communities;Community Health Aides;community partners;Complications of Diabetes Mellitus;Consolidated Framework for Implementation Research;Counseling;Country;Data;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Disproportionately impacts women;Early Diagnosis;effectiveness/implementation trial;Ensure;experience;Fasting;Foundations;Funding;Gestational Diabetes;Glucose;Goals;Government;Health;high risk;high risk population;High Risk Woman;Home;home test;Hospitals;Hour;Hybrids;implementation determinants;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation science;implementation/effectiveness;improved;Incidence;India;Intervention;Interview;Knowledge;Life;Link;Longitudinal cohort study;low and middle-income countries;Low income;Maternal Health;member;Methods;Modeling;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;OGTT;Oral;Participant;Pilot Projects;Population;post implementation;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention;primary outcome;programs;progression risk;Random Allocation;Randomized;Recommendation;Records;Research;Research Design;retention rate;screening;secondary analysis;Services;Slum;Societies;Structure;Surveys;Testing;testing uptake;Training;Trust;two-arm study;underserved community;United States National Institutes of Health;uptake;Urban Community;urban Native American;Woman;women's diagnosis;women's outcomes;World Health Organization

PROJECT_TITLE: A type 2 hybrid effectiveness-implementation trial of Community Health Workers to improve screening for postpartum diabetes in urban slums of India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(50)R]


ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Nearly 70% of patients with metastatic bladder cancer die of their disease despite current treatment with chemotherapy or immunotherapy, making the discovery of novel therapeutics an urgent imperative. We showed that mutations in the promoter of TElomerase Reverse Transcriptase (TERT), a protein which maintains telomere length and cellular immortality, occur in nearly 70% of bladder cancers and drive high TERT expression which contributes to tumor growth and poor patient prognosis. Here, we use an innovative platform for High-Throughput Screening (HTS) of small molecules that reduce TERT expression specifically from mutant TERT promoters in bladder cancer cells, with the overall objective of developing novel cancer cell specific therapeutics for bladder and other TERT driven malignancies.

PI_NAMEs: JACKSON, MICHAEL ;THEODORESCU, DAN  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Alleles;analog;aurora kinase A;Biological Assay;Bladder;Cancer Biology;cancer cell;Cancer cell line;cancer therapy;Catalogs;Cell Death;cell growth;Chemicals;cheminformatics;chemotherapy;Chimeric Proteins;Cisplatin;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;cytotoxicity;Data;Dependence;design;Disease;Dose;Drug Targeting;Effectiveness;Ensure;Evaluation;experimental study;FRAP1 gene;Future;Gene Expression Profile;Genetic Transcription;Goals;Growth;Head;Heterozygote;high throughput screening;Human;immune checkpoint blockade;Immunologic Surveillance;Immunotherapy;improved;In Vitro;inhibitor;innovation;kinase inhibitor;Length;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Marrow;Mediating;Monitor;Morphologic artifacts;mRNA Expression;mTOR inhibition;mutant;Mutation;new therapeutic target;novel;novel therapeutics;overexpression;patient prognosis;Patients;Performance;Pharmaceutical Preparations;Phenotype;promoter;Promoter Regions;protein degradation;Proteins;reconstitution;Reporter;Reproducibility;response;RNA-Directed DNA Polymerase;Role;scaffold;screening;self-renewal;Signal Transduction;Small Interfering RNA;small molecule;small molecule libraries;Specificity;stem cells;Structure-Activity Relationship;Telomerase;telomere;Telomere Length Maintenance;Testing;Therapeutic;therapeutic target;tool;Toxic effect;tumor;tumor growth

PROJECT_TITLE: Targeting the mutant promoter of Telomerase Reverse Transcriptase (TERT)

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Kappa opioid receptor (KOR) agonists have analgesic and anti-pruritic effects while KOR antagonists are potentially useful as anti-anxiety and antidepressant agents and for drug abuse treatment. The paraventricular nucleus of the thalamus (PVT), part of the brain anxiety network, expresses a high level of KOR and we propose to characterize these KOR-expressing PVT neurons in terms of afferent and efferent projections and functional significance in KOR- mediated behaviors. The proposed studies will enhance our understanding of KOR functional neuroanatomy and KOR-mediated anxiety, stress responses, aversion and other psychopathology with the hope that the results provide the basis for developing KOR antagonists as anti-anxiety agents.

PI_NAMEs: LIU-CHEN, LEE-YUAN  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abbreviations;Absence of pain sensation;Addictive Behavior;Amygdaloid structure;Analgesics;Anterior;Anti-Anxiety Agents;anti-depressive agents;Antipruritic Effect;Anxiety;anxiety-like behavior;Area;Arousal;base;Behavior;behavioral response;biological adaptation to stress;Brain;Brain region;Brain Stem;California;Cell Nucleus;Chronic;clinical development;Collaborations;conditional knockout;conditioned fear;Coping Behavior;Coupled;Diuresis;Dorsal;Drug abuse;Drug Addiction;Dynorphins;dysphoria;Enterobacteria phage P1 Cre recombinase;Exhibits;experience;Fright;genetic approach;Homeostasis;Human;Hypothalamic structure;In Situ Hybridization;in vivo;inducible Cre;Injections;kappa opioid receptors;Knock-in Mouse;Knockout Mice;Knowledge acquisition;Limbic System;Link;Literature;LoxP-flanked allele;Mediating;Mental Depression;Mental Health;Messenger RNA;Midline Thalamic Nuclei;Morphine;Mus;Mutant Strains Mice;Naloxone;negative affect;nerve supply;Neuroanatomy;neuronal circuitry;Neurons;Nucleus Accumbens;Opioid agonist;Opioid Antagonist;Opioid Receptor;pain model;Pathway interactions;Pennsylvania;Peptides;Play;Prefrontal Cortex;Proteins;Psychopathology;Publishing;Rabies;Rabies virus;receptor;Reporter;Research;response;Rewards;Rodent;Role;Secure;Seminal;Services;side effect;Source;Stress;Stress and Coping;Structure;Structure of paraventricular nucleus of thalamus;Structure of terminal stria nuclei of preoptic region;Tamoxifen;Testing;Time;Universities;Ventral Tegmental Area;Viral;Viral Vector;Virus;Visceral pain;Water;Withdrawal;Work

PROJECT_TITLE: Kappa Opioid Receptor in Paraventricular Nucleus of Thalamus

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

PHR: PROJECT NARRATIVE Almost two-thirds of breast cancers are the hormone-receptor positive subtype which are treated with adjuvant endocrine therapy (AET), yet up to 50% of patients do not take these medications as prescribed resulting with increased rates of breast cancer recurrence and death. Adherence to AET is lower among Black breast cancer survivors and this new mHealth, intervention will address a major barrier to AET adherence, symptoms from AET, in a tailored fashion to Black breast cancer survivors. This intervention has great promise for reducing cancer-related symptoms burden which negatively impact quality of life, reducing disparities in care, and potentially improving cancer outcomes among Black breast cancer survivors.

PI_NAMEs: LEE, KIMBERLEY T (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adherence;adjuvant endocrine therapy;behavior test;Behavior Therapy;behavioral clinical trial;Biological;black patient;Black Populations;Black race;black women;Breast Cancer survivor;cancer care;Cancer Center;cancer diagnosis;cancer health disparity;cancer recurrence;Cancer Survivor;Cancer Survivorship;candidate identification;care delivery;career;career development;Caring;Cessation of life;Clinical;Clinical Research;comparative efficacy;Comprehension;Consent;Control Groups;Data;Daughter;Department chair;Development;Development Plans;Discipline;disparities in women;Disparity;disparity reduction;Educational Materials;Educational workshop;efficacy evaluation;efficacy trial;Eligibility Determination;Encapsulated;Ensure;Environment;Epidemiologic Methods;Epidemiology;experience;Feedback;Foundations;Funding;Future;Goals;health care disparity;health disparity populations;Health Technology;High Risk Woman;hormone receptor-positive;hormone therapy;improved;innovation;Institution;Intervention;intervention participants;intervention refinement;Interview;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;medication compliance;Mentorship;Methods;mHealth;mhealth interventions;mHealth methodology;Minority;Modeling;Monitor;Observational epidemiology;Oncology;Outcome;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;Population;Population Sciences;Positioning Attribute;Preparation;programs;Provider;Publishing;Qualitative Methods;Quality of life;racial diversity;racism;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;recruit;Recurrence;Reporting;Research;Resources;Risk Reduction;Scientist;skills;social cognitive theory;Solid;Specimen;Structure;survival disparity;Survival Rate;symposium;Symptom Burden;symptom management;Symptoms;tailored messaging;Technology;Testing;theories;therapy adherence;therapy development;Training;treatment as usual;Treatment Efficacy;Trust;urinary;Vulnerable Populations;White Women;Woman;women's diagnosis;Work

PROJECT_TITLE: Developing a culturally tailored mHealth symptom monitoring intervention to improve adherence to endocrine therapy among Black women with breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Headaches;Migraine;Neurosciences;Pain Research;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chronic pain is a highly prevalent disorder that results in significant disability for both adults and children. Chronic pain remains difficult to diagnose and treat because we do not understand how components of the nervous system work together to build an experience of pain. The fundamental knowledge gained in this project will provide the foundation for better diagnosis and effective treatments for chronic pain.

PI_NAMEs: COGHILL, ROBERT C (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Abdominal Pain;accurate diagnosis;Address;Adolescent;Adult;Affect;Age;Anxiety;Area;Automobile Driving;Basic Science;Brain;Caring;Central Nervous System;Child;Childhood;chronic pain;chronic pain management;Chronic pain syndrome;chronic painful condition;chronic widespread pain;Clinical Trials;Complex;Complex Regional Pain Syndromes;Data;Development;Diagnosis;Diagnostic;diagnostic biomarker;disability;Discipline;Disease;effective therapy;experience;Face;follow-up;Foundations;Functional Magnetic Resonance Imaging;Future;Health Care Costs;High Prevalence;Human;innovation;Inpatients;insight;Investigation;Knowledge;Medical;Mental Depression;Migraine;multidisciplinary;Musculoskeletal Pain;Nervous System;neuroimaging;Nociception;Nonpharmacologic Therapy;Outcome;Outpatients;Pain;Pain intensity;Pain management;Pain Map;Participant;Patient Care;Patients;pediatric patients;pharmacologic;Pharmacological Treatment;Positioning Attribute;predicting response;Prevalence;Process;prospective;psychologic;Recovery;recruit;Rehabilitation therapy;Sampling;Schools;Scientist;Sensory;sex;social;Source;Spatial Distribution;Symptoms;System;Testing;Translational Research;Uncertainty;Work;Youth

PROJECT_TITLE: Supraspinal Processing of Sensory Aspects of Pain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: IBADAN

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN

PHR: NARRATIVE Brain health, which determines brain capital, is central to achieving overall health and all sustainable development goals. However, the current DS-I Africa programs do not have a dedicated training program in brain health research to unravel its determinants, especially sociodemographic and lifestyle factors which play a major role elsewhere. GRASP is aimed at developing a sustainable cohort of African scientists to tackle the brain health burden in Africa by improving the data science skill of selected scholars to unravel its determinants using available large integrated datasets within DSI-A network. 1

PI_NAMEs: FATUMO, SEGUN ;OVBIAGELE, BRUCE ;OWOLABI, MAYOWA OJO (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Address;Affect;Africa;African;Area;Articulation;big-data science;Brain;brain health;Brain imaging;Capital;cardiovascular risk factor;Cardiovascular system;career;Cause of Death;cerebrovascular;certificate program;Climate;Cognitive;cohort;Creativeness;Credentialing;Data;data integration;data management;Data Science;Data Set;Dedications;Diagnostic;Dietary Factors;disability;Disease;Early Intervention;educational atmosphere;Effectiveness;effectiveness evaluation;expectation;Faculty;Funding;genomic data;Genomics;Geography;GIS Imaging;global health;Goals;Health;health data;health science research;Human Resources;Impairment;improved;Indigenous;Individual;Infrastructure;innovation;Institution;Intervention;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;lifestyle factors;Maps;member;Mentors;Mentorship;Methods;Monitor;Motivation;multidisciplinary;Nervous System Disorder;neuroimaging;Nigeria;novel;novel strategies;Observational Study;Pattern;peer coaching;Personal Satisfaction;Play;Population;Positioning Attribute;Precision therapeutics;preference;Preventive;Primary Prevention;programs;Public Health;Publications;Qualifying;randomized trial;Research;Research Personnel;Research Project Grants;Residencies;Resources;Risk;risk prediction;Role;Scientist;skills;sociodemographic factors;sociodemographics;success;Support System;Sustainable Development;Thinking;Time;Training;Training Activity;Training Programs;Underrepresented Populations;Universities

PROJECT_TITLE: Growing Data-science Research in Africa to Stimulate Progress (GRASP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Intervention INC: An interactive family-centered mHealth tool to reduce obesity risk in urban minority preadolescents study will test the effectiveness of the adapted tool on child BMI z-score, with a full-scale randomized controlled trial. Critical preliminary data will also be collected on perceptions of the intervention at the organizational and family levels and characteristics of recipients (clinic staff, children, and parents), as well as the contextual factors that influence the tool’s implementation in a health care setting. This study has strong public health relevance as not only does the tool use innovative communication approaches to deliver complex health messages in a simple and meaningful way to engage an often hard to reach population, but the data collected will ultimately inform the more efficient and effective delivery and use of culturally relevant health care resources for a diverse, at-risk population.

PI_NAMEs: LEUNG, MAY MAY  (contact)

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


PHR: PROJECT NARRATIVE: OVERALL We propose the creation of the USC Center for Optimization of Participant Engagement in Cancer Characterization (COPECC) with a focus on optimizing the engagement of Hispanic/Latinos in colorectal cancer (CRC) Genomic Characterization research studies, as part of the NCI U2C Participant Engagement and Cancer Genome Sequencing national network. The overall goal of USC COPECC is to generate results on participant engagement optimization and translational CRC genomic research that will be shared with the broader community to promote best practices for engaging Hispanic/Latino and improving overall outcomes for CRC in this underserved population.

PI_NAMEs: CARPTEN, JOHN D.;LENZ, HEINZ JOSEF  (contact)

PROGRAM_OFFICER_NAME: GILLANDERS, ELIZABETH

PROJECT_TERMS: Address;Advocate;African American population;Age;Age Years;Area;Behavioral;Behavioral Sciences;Biology;Biomedical Research;California;cancer care;Cancer Etiology;cancer genome;cancer genomics;caucasian American;Cause of Death;Cessation of life;Characteristics;Clinic;Clinical;Clinical Data;clinical translation;Collaborations;colon cancer patients;Colorectal Cancer;Communication;Communities;community engagement;Community Healthcare;Community Outreach;Consent;Data Analyses;demographics;design;Diagnosis;Disease;early onset colorectal cancer;Ethnic Population;Etiology;Fasting;Fostering;Genome;genome sequencing;genomic data;Genomics;Goals;health care settings;Health Services Accessibility;High Prevalence;Hispanic;Hispanic Populations;improved;Incidence;Knowledge;Laboratories;Latino;Latino Population;Malignant Neoplasms;Medical;member;Mexican;minority patient;Molecular;Not Hispanic or Latino;novel;novel strategies;Outcome;participant enrollment;patient engagement;patient population;Patient Preferences;Patient-Focused Outcomes;Patients;Positioning Attribute;Process;Rectal Cancer;Reporting;Research;research study;Risk;Scientist;socioeconomics;Subgroup;Taxonomy;Techniques;Technology;Testing;The Cancer Genome Atlas;Time;translational cancer research;translational genomics;Treatment Factor;Underrepresented Minority;Underserved Population

PROJECT_TITLE: USC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization Studies