NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative: The Baylor College of Medicine Post-baccalaureate Research Education Program (BCM PREP) will mentor college graduates who are underrepresented (UR) in science and medicine to be successful to progress into research-intensive biomedical Ph.D. programs and in research and research-related careers. The curriculum and training include mentored, original research in a laboratory, science writing and oral presentation skills, analysis of the scientific and medical literature, critical thinking and evaluation, responsible conduct of research, and the principles of scientific rigor and reproducibility. The BCM PREP Scholars will develop knowledge and experience in foundational science and clinical and translational research questions that is supplemented with mentorship and training in leadership and communication skills, fostering confidence and independence, and to serve as role models for UR students and colleagues and help educate theirs and the broader communities about biomedical research and health care developments.

PI_NAMEs: PEREIRA, FRED A (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Academia;Academic support;Achievement;African American population;Biomedical Research;career;Clinical Research;college;Communication;Communities;Competence;Core Facility;Critical Thinking;Development;Development Plans;Doctor of Philosophy;economic disparity;Education;education research;Educational Curriculum;Educational workshop;Enrollment;Ensure;Environment;Evaluation;experience;faculty mentor;Feeling;Fellowship;Fostering;Foundations;Funding;Goals;graduate student;Grant;Health;Health Professional;Healthcare;Hispanic Populations;improved;Individual;innovation;Institution;Interdisciplinary Study;interest;Interpersonal Relations;Knowledge;Laboratories;laboratory facility;Laboratory Research;Latinx;Leadership;Learning;Literature;Mathematics;Medical;Medical Research;Medicine;Mentors;Mentorship;Mind;Mission;Molecular and Cellular Biology;Morbidity - disease rate;mortality;National Institute of General Medical Sciences;Native Americans;Occupations;Oral;outreach;Pacific Islander;peer;peer coaching;Persons;Physically Challenged;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Productivity;Professional Competence;programs;Recording of previous events;Records;recruit;Reproducibility;Research;research faculty;Research Personnel;Research Support;Research Training;responsible research conduct;Role;role model;Schedule;Scholars Program;Science;Scientist;Series;skills;social;Students;success;symposium;Testing;Training;Training Support;Translational Research;tutoring;undergraduate student;Underrepresented Populations;Underrepresented Students;Wages;Woman;Work;Writing

PROJECT_TITLE: YEARS 19 - 23:  BCM POST-BACCALAUREATE RESEARCH EDUCATION PROGRAM

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: IBRAHIM, JOSEPH G (contact)

PROJECT_TERMS: Appointment;Area;Basic Science;Big Data;Biometry;Biostatistics Shared Resource;Budgets;Cancer Center;Cancer Center Support Grant;Caregivers;circadian;Clinic;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Computational Biology;Consultations;cost;Data;Data Analyses;Data Set;deep learning;design;Detection;DNA Repair;Dose;Evaluation;experience;Experimental Designs;Faculty;Funding;Gene Expression;Generations;Genetic;genomic predictors;Genomics;graduate student;Grant;Growth;Heart Atrium;high dimensionality;Human Resources;Image;innovation;Institution;International;Joints;Malignant Breast Neoplasm;Manuscripts;Maps;member;method development;Methods;Methylation;Monitor;novel;Patients;peer;Population Sciences;Preparation;procedure safety;Process;programs;Protocols documentation;Psychometrics;Public Health Schools;Publications;randomized, clinical trials;Reading;Research;Research Design;Research Personnel;Review Committee;Safety;Sample Size;Sampling;Science;senior faculty;Services;Signal Transduction;skills;Source;Statistical Data Interpretation;Statistical Models;Students;Symptoms;System;Training;transcriptome sequencing;Translational Research;tumor;Universities;virtual;Walking;Work;Writing

PROJECT_TITLE: Biostatistics

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Improved exposure and risk assessment methods, particularly for heavy metal mixtures in private wells surrounding Superfund sites, and information on the field-effectiveness of water treatment technology are needed to manage contaminated site remediation goals and develop drinking water guidance. This project will develop a novel statistical tool to forecast the contribution of Superfund sites to heavy metal mixtures in private wells and will evaluate the effectiveness of water treatment technologies to remove heavy metal concentrations in public water supplies. The hybrid mechanistic-empirical models for heavy metals in drinking water developed as part of this project can be broadly used to identify populations potentially at risk for elevated exposures to heavy metals through contaminated drinking water.

PI_NAMEs: SUNDERLAND, ELSIE MARECA (contact)

PROJECT_TERMS: 5 year old;Address;Affect;Archives;Arsenic;Biomedical Research;Brain;Cadmium;Child;Chromium;Cognitive;Cognitive aging;Colorado;community engagement;Consumption;contaminated drinking water;contaminated water;Country;Data;Databases;Development;Diagnosis;disease registry;drinking water;early life exposure;Effectiveness;effectiveness evaluation;Elements;exposed human population;Exposure to;geochemistry;Geographic Locations;Geological Survey;Goals;ground water;Guidelines;Health;Heavy Metals;high risk;Hybrids;Immunosuppression;improved;In Vitro;Individual;Information Systems;innovative technologies;insight;land use;late life;Lead;Link;Location;machine learning algorithm;Malignant Neoplasms;Manganese;Maps;Measurement;Metal exposure;Metals;Methods;Modeling;Municipalities;neurodevelopment;novel;Nurses' Health Study;Organoids;Oxidation-Reduction;Pattern;Persons;Poison;Population;Privatization;Process;Property;Prospective cohort;Public Health;Regulation;remediation;Research;Research Priority;Risk;Risk Assessment;risk mitigation;Role;Sampling;Selenium;Site;Soil;Source;Superfund;superfund site;Surface;System;Technology;Testing;Time;tool;Toxicity Tests;Trace metal;Training;Treatment Effectiveness;United States;Water;Water Pollutants;water quality;water sampling;Water Supply;water treatment;Woman;Work

PROJECT_TITLE: Spatial patterns of metals and metal mixtures in drinking water


PI_NAMEs: KIM, HONG JIN  (contact)

PROJECT_TERMS: Administrator;Anatomy;anti-cancer research;Blood;Budgets;Cancer Center Support Grant;Cells;ChIP-seq;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Collection;Consent;cost;data management;Databases;demographics;Dissociation;Ensure;Event;experience;experimental study;Faculty;Fresh Tissue;Future;Goals;Guidelines;Hospitals;Improve Access;Infrastructure;Institution;Leadership;Maintenance;Malignant Neoplasms;meetings;member;Methodology;next generation;Noise;Nucleic Acids;Operative Surgical Procedures;Pathologist;Pathology;Patients;peer;Physician Executives;Plasma;Policies;Process;programs;Protocols documentation;Research;Research Personnel;Resource Sharing;Resources;Sampling;Science;Services;Signal Transduction;single cell sequencing;Sister;Source;Specialist;Specimen;Speed;Strategic Planning;Surgical Pathology;Technology;Tissue Banks;tissue processing;Tissue Procurements;Tissues;Translational Research;virtual;Work

PROJECT_TITLE: Tissue Procurement Facility & Biospecimen


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Patient Safety;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The recent approval of adjuvant immunotherapy for stage II melanoma has brought a new urgency to improving our methods to accurately identify patients who may benefit from adjuvant therapy, and distinguish them from surgically cured patients who could only be potentially harmed by the treatment. Treatment can reduce the chance of tumor recurrence; however, most stage II melanoma patients are surgically cured and will never recur, so adjuvant therapy is unnecessary. The goal of this project is to test the ability of candidate biomarkers to improve our current methods of distinguishing surgically cured patients from those at significant risk of post- surgical recurrence.

PI_NAMEs: POLSKY, DAVID  (contact)

PROGRAM_OFFICER_NAME: THURIN, MAGDALENA

PROJECT_TERMS: Academy;Adjuvant;Adjuvant Therapy;American;anti-PD-1;Automobile Driving;Biological Markers;biomarker validation;BRAF gene;candidate marker;Categories;Classification;Clinic;Clinical;clinical biomarkers;cohort;Collaborations;Colon Carcinoma;cost;Cutaneous Melanoma;Data;Data Set;Decision Making;Dermatology;Diagnostic Neoplasm Staging;Disease;disease prognosis;DNA;Enrollment;Epigenetic Process;Event;Excision;follow-up;Gene Mutation;Genes;genetic variant;Germ Lines;Germ-Line Mutation;Goals;Guidelines;high risk;Histopathology;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;Inherited;interest;Malignant Breast Neoplasm;Measurement;Measures;Melanoma;Melanoma patient;Metastatic Melanoma;Methods;Methylation;Mitosis;Modeling;Molecular;molecular pathology;Multicenter Trials;Mutation;mutational status;National Comprehensive Cancer Network;neoplastic cell;NF1 gene;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Outcome;overtreatment;Pathogenicity;Patient risk;Patient Selection;Patients;pembrolizumab;Pharmaceutical Preparations;placebo group;Placebos;Population;predictive modeling;prevent;Primary Neoplasm;Probability;prognostic;Prognostic Marker;prognostic tool;prognostic value;prognostication;promoter;Promoter Regions;prospective;Prospective cohort;Publications;Publishing;randomized placebo-controlled clinical trial;randomized, clinical trials;Recommendation;Recurrence;Recurrent tumor;relapse risk;Resected;Risk;RNA-Directed DNA Polymerase;Sampling;Site;Staging System;standard of care;Standardization;Subgroup;survival outcome;Techniques;Telomerase;Testing;Therapeutic;Thick;tool;Toxic effect;Treatment Effectiveness;Treatment-related toxicity;tumor;Tumor-Derived;Ulcer;Validation;validation studies;Variant

PROJECT_TITLE: TERT epigenetic and genomic variants in stage II melanoma as biomarkers of outcome


NIH_SPENDING_CATS: Aging;Bioengineering;Foodborne Illness;Machine Learning and Artificial Intelligence;Nanotechnology

PHR: PROJECT NARRATIVE Removing pollutants from contaminated drinking water is critical for public health, but traditional approaches to sorption of pollutants are insufficiently selective towards remove arsenic, chromium or selenium. We propose to revolutionize sorbent design by combining novel polymer and nano-science technologies with quantum mechanical simulations, machine learning, and molecular mass transport models. The proposed approach will lead to new selective sorbent materials for a variety of water treatment systems (e.g., individual households on wellwater, small-scale community systems or schools) that are more effective, efficient, and sustainable to reduce exposure to Superfund metals from drinking water compared against existing technologies.

PI_NAMEs: ZIMMERMAN, JULIE  (contact)

PROJECT_TERMS: absorption;Active Sites;Adsorption;Affinity;Amines;Analysis of Variance;aqueous;Area;Arsenic;artificial neural network;Attenuated;Beds;Behavioral;Benchmarking;Benign;Binding Sites;Biopolymers;Calibration;Charge;chemical property;Chemical Structure;Chemicals;Chemistry;Chitosan;Chromium;Code;Cognitive aging;common treatment;Communities;competitive environment;Complex;contaminated drinking water;cost;critical period;crosslink;Crosslinker;crystallinity;data modeling;Data Set;density;design;Devices;drinking water;Effectiveness;electronic structure;Electronics;Electrostatics;Excision;Exclusion;Exhibits;experimental study;Exposure to;Fiber;fluid flow;Fourier Transform;Generations;geometric structure;Goals;Hazardous Waste;Health;Household;Human;Hydrophobicity;hydroxyl group;improved;in silico;In Situ;Individual;innovation;inorganic phosphate;ionization;Ions;Iron;iterative design;Life;light scattering;Machine Learning;metal oxide;Metals;Methods;Modeling;molecular dynamics;molecular mass;Morphology;nano;nanoscience;Nerve Degeneration;Neurotoxins;next generation;novel;Oxides;pollutant;Polymers;Porosity;Process;Public Health;Quantum Mechanics;remediation;Resolution;Roentgen Rays;Scanning Electron Microscopy;Schools;Selenium;Shapes;Silicates;simulation;Site;Source;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Structure;success;Sulfate;Superfund;superfund site;Surface;Surface Properties;System;Technology;Testing;theories;Thermodynamics;training data;Transition Elements;Transmission Electron Microscopy;treatment strategy;Vertebral column;Water;water quality;water treatment;well water;X ray diffraction analysis;zeta potential

PROJECT_TITLE: Designing the next generation of highly selective sorbent materials for remediation of target inorganic contaminants in aqueous systems


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Supravalvular aortic stenosis (SVAS) is a devastating developmental genetic disease characterized by accumulation of excess smooth muscle cells which narrows the aorta, reducing blood flow and putting a heightened load on the heart. We recently discovered that a specific set of molecules, known as the Notch pathway, plays a key role in this disease and is modulated by a gene regulatory system known as epigenetics. We propose to use mouse models as well as human cells and tissue samples and cutting-edge epigenetic approaches to study underlying mechanisms and thus delineate concrete steps towards developing novel therapeutic approaches for SVAS and other vascular diseases.

PI_NAMEs: GREIF, DANIEL  (contact);MARTIN, KATHLEEN ANN

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Aorta;Aortic Valve Stenosis;Arterial Occlusive Diseases;Arteries;Attenuated;attenuation;Birth;Blood flow;Cardiovascular Diseases;cell behavior;Cell Culture Techniques;Cell Differentiation process;Cell Nucleus;Cell Proliferation;Cell Separation;Cells;Cellular biology;Chromatin;chromatin remodeling;Coupled;Data;Development;developmental genetics;Disease;DNA Methylation;DNA Modification Methylases;Elasticity;Elastin;Embryo;Enzymes;Epigenetic Process;epigenetic regulation;gamma secretase;Gene Expression;gene repression;Genes;Genetic Diseases;genome-wide;genomic profiling;Genomics;HDAC1 gene;Heart;Heart failure;Histone Acetylation;Histone Deacetylase;Human;in vivo;induced pluripotent stem cell;Kinetics;Left;Ligands;Link;loss of function mutation;Loss of Heterozygosity;Mediating;Mediator;Medical;Modification;Molecular;mouse model;Mus;Muscle Cells;mutant;Mutant Strains Mice;neonatal mice;notch protein;NOTCH3 gene;novel;novel therapeutic intervention;Obstruction;Operative Surgical Procedures;Paper;Pathogenesis;Pathology;Pathway interactions;Patients;Play;Proliferating;pup;receptor;Reporting;Repression;Risk;Role;Sampling;Signal Transduction;Smooth Muscle Myocytes;Stenosis;Sudden Death;Supravalvular aortic stenosis;System;Techniques;Testing;therapeutic target;Tissue Sample;Tissues;transcriptomics;Transgenic Mice;Tropoelastin;Vascular Diseases;Williams Syndrome

PROJECT_TITLE: Epigenetic-mediated Notch pathway activation promotes elastin aortopathy

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE R-loops may be the greatest source of DNA damage at telomeres leading to cancer and accelerated aging. While known to occur and at high levels in the ALT cancer phenotype, almost nothing is known about their size, clustering, or location along the telomere or generation by toxic insult due to toxic chemicals or radiation. Our unique EM methods will answer these key questions, allowing rapid advancement of the field.

PI_NAMEs: GRIFFITH, JACK D (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: 8-hydroxyguanosine;Affinity;age acceleration;Aging;Antibodies;Binding;Biological Assay;Cells;Chromatin Loop;Chromosomal Rearrangement;Cisplatin;Collaborations;Complex;crosslink;Cryoelectron Microscopy;DNA;DNA Damage;DNA Sequence;Educational workshop;Electrons;Exposure to;Formaldehyde;Frequencies;Funding;G-Quartets;Generations;Genes;Genetic Recombination;Genetic Transcription;Genomic Instability;Genomics;Hand;Hela Cells;Human;Hybrids;Immunoprecipitation;in vivo;instrumentation;Laboratories;Lead;Left;Lesion;Link;Location;Malignant Neoplasms;Maps;Measures;Metabolism;Methods;Methyltransferase;Microscopic;Mutagenesis;Mutate;novel;Nucleic Acids;oxidative damage;Oxygen;particle;Peer Review;Phenotype;Plasmids;Play;Poison;Preparation;protein complex;Proteins;Publications;Radiation;Resolution;Resolvase;ribonuclease H1;RNA;Role;Sampling;Single-Stranded DNA;Site;Small Interfering RNA;Source;Structure;System;Technology;Telomerase;telomere;telomere damage;Testing;tool;Training;Transcriptional Regulation;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: R-loops at the telomere as a toxic source of genomic instability

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Annual Reports;Attention;Basic Science;Biological;career development;Clinical Research;Collaborations;Communication;Communities;Complex;Cues;Data;Delaware;Development;Development Plans;Disease;Ensure;Evaluation;Extramural Activities;Faculty;formative assessment;Functional disorder;Funding;Future;Goals;Grant;Growth;Health;improved;Infrastructure;Leadership;meetings;Mentors;Musculoskeletal;Musculoskeletal Diseases;novel;Office of Administrative Management;operation;Periodicals;pre-clinical;pre-clinical research;Program Development;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Structure;success;Therapeutic Intervention;Tissues;tool;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Delaware Center for Musculoskeletal Research – Administrative Core


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: The newly envisioned Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) is a multi- component collaborative research enterprise focused on the reduction of new HIV infections among adolescents and young adults in the US as well as improvements across the HIV continuum of care for youth living with HIV. The Scientific Leadership Center (SLC), led by Drs. Hightow-Weidman and Hosek, will bring all elements together and ensure that they function collaboratively, effectively, and efficiently with the Operations and Collaboration Center (OCC), NIH, and the overall network. Seven highly innovative and impactful clinical trials, led by talented multi-disciplinary teams that address all five ATN priority research areas, span key populations of youth, multiple socioecological systems, and a variety of regulatory phases are included.

PI_NAMEs: HIGHTOW-WEIDMAN, LISA B (contact);HOSEK, SYBIL

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health outcomes;adolescent HIV prevention;Adolescent Medicine Trials Network;Age;age group;AIDS prevention;Area;career;Caring;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communication;Communities;community-level factor;Complex;Continuity of Patient Care;design;Development;Elements;Emotional;Ensure;Epidemic;evidence base;Evolution;experience;Friends;Goals;Growth;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;HIV/STD;improved;Individual;Infection;Infrastructure;innovation;insight;Intervention;Leadership;medical appointment;Mental Health;Mission;multidisciplinary;Neurocognitive;Oils;operation;Ownership;Pharmaceutical Preparations;Phase;Population;Poverty;pre-exposure prophylaxis;Prevalence;Prevention;Productivity;programs;Qualifying;racism;Research;Research Priority;resilience;Resources;Science;Social Change;social stigma;Structure;Substance abuse problem;System;Talents;United States;United States National Institutes of Health;uptake;Violence;Viral;Vision;Work;young adult;Youth

PROJECT_TITLE: Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: HIGHTOW-WEIDMAN, LISA B (contact)

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;adolescent HIV prevention;Adolescent Medicine Trials Network;Area;Articulation;Bioethics;Caring;Clinical;clinical development;Clinical Investigator;clinical practice;Clinical Protocols;Clinical Trials;co-infection;Cognitive;Collaborations;Communication;Community Practice;comorbidity;data management;design;Development;diagnostic technologies;Discipline;Dissemination and Implementation;Effectiveness;Emotional;Ensure;Epidemic;Equity;ethnic identity;experience;flexibility;Fostering;Funding;Future;Gender Identity;Geography;Goals;health equity;HIV;HIV-infected adolescents;HIV/AIDS;industry partner;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Intervention Studies;Intervention Trial;Investments;Knowledge;laboratory equipment;Leadership;lens;member;Mentors;Mission;mobile computing;multidisciplinary;next generation;operation;Outcome;Policies;policy recommendation;Positioning Attribute;Practice Guidelines;Prevention;Prevention strategy;Problem Solving;Public Health;Publications;Qualifying;racial identity;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;resilience;Resource-limited setting;response;Risk;Role;Science;sexual identity;Site;social;synergism;Therapeutic;therapy design;Training;Translating;Translations;Underrepresented Minority;United States;United States National Institutes of Health;working group;Youth

PROJECT_TITLE: Scientific Leadership Group Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: WANG, LIYUN  (contact)

PROJECT_TERMS: Acceleration;Animals;Basic Science;bioimaging;Biological;Biological Models;Biological Sciences;biomechanical model;Biomechanics;Biomedical Research;Biometry;biophysical model;Biophysics;Biotechnology;Collaborations;Communities;Competence;Computers and Advanced Instrumentation;Cues;Dedications;Delaware;design;Disease;Educational workshop;Engineering;Ensure;Equipment;Functional disorder;Funding;Goals;Health;Image;imaging facilities;Imaging Techniques;in vivo imaging;Individual;instrument;instrumentation;Lead;Leadership;Measurement;mechanical load;Methodology;Molecular;Multiscale Mechanics;Musculoskeletal;Organism;Physical assessment;pre-clinical;Pre-Clinical Model;pre-clinical research;programs;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Scientist;Services;Signal Transduction;square foot;Structure;success;Technical Expertise;Techniques;Therapeutic Intervention;Tissues;Training;Universities;Work

PROJECT_TITLE: Delaware Center for Musculoskeletal Research – Multiscale Assessments Research Core


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care;Sexually Transmitted Infections;Substance Misuse;Telehealth

PROJECT_TERMS: Accident and Emergency department;Accounting;Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Medicine Trials Network;Adult;Affect;age group;AIDS prevention;antiretroviral therapy;Applied Research;Awareness;Behavior;behavior change;candidate identification;Caring;Centers for Disease Control and Prevention (U.S.);Chlamydia;Clinic;Clinical;clinical decision support;Clinical effectiveness;clinical practice;Collection;comparative effectiveness trial;computed tomography screening;computerized;Consensus;cost;cost effective;cost effectiveness;Data;Data Reporting;design;Diagnosis;digital health;digital healthcare;Electronic Health Record;Electronics;Emergency Care;Emergency department visit;Epidemic;evidence base;Geographic Locations;Geography;Goals;Gonorrhea;health care settings;Health education;Health Status;Health Technology;Healthcare;high risk;high risk sexual behavior;HIV;HIV Infections;HIV/AIDS;Hour;Human immunodeficiency virus test;improved;Infection;Infection prevention;Infrastructure;innovation;insight;Intervention;Leadership;Link;Literature;Location;Logistics;Methods;mHealth;Modeling;novel;Outcome;Patient Outcomes Assessments;Patients;pediatric emergency;Persons;Population;pragmatic trial;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Preventive healthcare;Primary Care;primary care services;Provider;Recommendation;Research;response;Risk;Risk Assessment;Risk Factors;screening;screening program;Sexual Health;Site;stem;success;System;telehealth;Test Result;Text Messaging;Translating;treatment adherence;United States;uptake;Viral;Work;Youth

PROJECT_TITLE: RP1 Screen 2 Prevent


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This application seeks to fund undergraduates from minority, disadvantaged, and underrepresented backgrounds from the Intermountain West to participate in a 10-week summer research experience, studying heart, lung, or blood health, and a concurrent education and career development series at the University of Utah.

PI_NAMEs: AROMOLARAN, ADEMUYIWA ;FRANKLIN, SARAH  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Abbreviations;Address;Advanced Placement;Advisory Committees;Affect;Area;Bachelor's Degree;Behavioral;Behavioral Research;Biomedical Research;Blood;Cardiovascular Diseases;career;Career Choice;career development;Chronic lung disease;Clinical;Clinical Research;college;Communities;Critical Thinking;Data;Development;Development Plans;Disadvantaged;disadvantaged background;disadvantaged student;Disparity population;Diverse Workforce;Education;education resources;Educational workshop;efficacy evaluation;Enrollment;Ensure;Ethnic Origin;Ethnic Population;Evaluation;experience;Exposure to;Face;Faculty;faculty mentor;Feedback;Food;Foundations;Funding;Gender;Geography;Goals;graduate school;graduate student;Health;Health Sciences;Healthcare;Heart;higher education;improved;Individual;Inequity;Internet;lectures;Letters;Low income;Lung;Medical Students;Medically Underserved Area;member;Mentors;Mentorship;Mind;Minority;minority communities;Minority Groups;minority student;minority undergraduate;Mission;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Occupations;Participant;peer;programs;Race;racial population;Recommendation;Research;Research Activity;Research Training;Resources;role model;Rural;rural area;Rural Community;rural dwellers;Rural Population;Schools;Science;science education;science teacher;Series;Sleep;social health determinants;Social support;Solid;Speed;Stroke;student participation;Students;summer research;support network;Training;Translating;Transportation;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;United States National Institutes of Health;Universities;Urban Population;Utah;Writing

PROJECT_TITLE: RUUTEs: Summer Undergraduate Research Experience (SURE) for Minorities


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Hematology;Infectious Diseases;Physical Rehabilitation;Rehabilitation;Sepsis

PI_NAMEs: CORBIN, ELISE ANNE (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Animal Model;Area;Biocompatible Materials;Bioenergetics;Biological Models;Chronic;Complex;Contracts;cytokine;Delaware;Development;Devices;Disease;Dose;effective therapy;Engineering;Environment;Evolution;Exposure to;Extracellular Matrix;Fiber;Functional disorder;Future;Generations;Goals;Human;Immune response;Impairment;improved;In Vitro;in vitro Model;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Interleukin-1 beta;Long-Term Effects;Mechanics;Mediating;Medical;Methodology;Modeling;Morphology;Muscle;Muscle Fibers;muscle form;Muscle function;muscle strength;Muscular Atrophy;muscular structure;Musculoskeletal;Myopathy;novel;Organoids;Pathologic;Pathology;pharmacologic;Physical therapy;Physiological;preservation;Quality of life;Recovery;Reporter;Research;Resistance;resistance exercise;response;Risk;Role;scaffold;screening;Sepsis;septic patients;Skeletal Muscle;Structure;Study models;Survivors;Syndrome;Testing;Therapeutic;Therapeutic Effect;Tissue Model;Tissues;TNF gene;tool;treatment strategy;wasting;Work

PROJECT_TITLE: Competition between Resistance Training and Inflammation in an On-Chip Skeletal Muscle Microtissue Model of Sepsis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Gallbladder);Liver Disease;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The main aim of this proposal is to develop new potential therapeutic approaches for polycystic liver disease and cholangiocarcinoma. Our proposed studies will uncover novel and generalizable information on the fundamental mechanisms of ciliary dependent regulation of EGFR signaling.

PI_NAMEs: GRADILONE, SERGIO A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetylation;alpha Tubulin;Autophagocytosis;bile duct;biliary tract;Biliary Tract Diseases;Biogenesis;CBL gene;cell growth;Cell Line;cell motility;Cells;Cholangiocarcinoma;cholangiocyte;Cilia;Clinical Trials;combinatorial;Communication;Cytoplasm;Data;Deacetylase;Deacetylation;Defect;design;Development;Disease;Ductal Epithelial Cell;EGF gene;Environment;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epithelial Cells;Erlotinib;experimental study;Family member;Foundations;Functional disorder;Goals;HDAC6 gene;Histone Deacetylase;In Vitro;in vivo;inhibition of autophagy;Inhibition of Cell Proliferation;inhibitor;Leucine Zippers;Liver;Lysine;malformation;migration;Molecular;multisensory;Mus;Needs Assessment;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Organelles;overexpression;Pathogenesis;Pathologic;patient derived xenograft model;polycystic liver disease;pre-clinical;Process;Proteins;receptor;Receptor Inhibition;Receptor Signaling;Regulation;restoration;Rodent Model;Role;Sensory;Signal Pathway;Signal Transduction;SIRT1 gene;Structure;Testing;Therapeutic;transcription factor;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Primary cilia loss in bile duct cells- the interplay with the autophagy machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Lyme disease, the most prevalent vector-borne illness in the Northern Hemisphere, is continuing to expand in geographic range and case numbers, and a significant burden on the health system in endemic regions. The causative organism, Borrelia burgdorferi, produces a complex array of proteins (adhesins) that bind to mammalian tissue components and that contribute to the ability of the bacteria to cause infection. The three principal investigators together form a team with unique expertise that will allow comprehensive investigations of the functions of B. burgdorferi adhesins in multiple steps of the infection process, including changes in the cells lining blood vessels, a step that allows bacterial escape and invasion of host tissues.

PI_NAMEs: CHACONAS, GEORGE ;COBURN, JENIFER L (contact);LEONG, JOHN M

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Adhesives;Animals;Arthritis;Bacteria;Bacterial Adhesins;Binding;Biochemical;Biology;Blood Vessels;Borrelia afzelii;Borrelia burgdorferi;Borrelia garinii;CCL2 gene;Cell Line;Cells;Chemosensitization;chronic infection;Complex;cytokine;DBL Oncoprotein;decorin binding protein B;Endothelial Cells;Endothelium;Event;Extracellular Matrix;Gene Family;Generations;Genes;genetic analysis;Genetic Transcription;genome wide screen;Geography;Health system;Hematogenous;Hour;in vivo;Infection;Infectious Skin Diseases;inhibitor;insight;Integrin Binding;Interleukin-10;Intravenous;intravital microscopy;Invaded;Investigation;Joints;Laboratories;Left;Ligands;Lyme Disease;Measures;Mediating;meetings;microbial colonization;migration;Modeling;Monitor;mouse model;Mus;mutant;Nature;neutrophil;novel;Order Spirochaetales;Organism;OspC protein;pathogenic microbe;Phase;Prevention;Principal Investigator;Process;Protein Array;Research Personnel;Role;Skin;Testing;tick bite;Time;Tissues;TNF gene;transmission process;vector tick;Vector-transmitted infectious disease;virtual;Visualization

PROJECT_TITLE: The roles of Lyme spirochete adhesins in hematogenous dissemination


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PROJECT_TERMS: Accounting;Address;Adherence;Adolescent;Adolescent Medicine Trials Network;Adoption;Age;aged;AIDS prevention;arm;Biometry;Bisexual;Blood;California;Caring;Cellular Phone;Collection;Communication;Conflict (Psychology);cost;cost effective;cost effectiveness;cost estimate;Cost Measures;cost-effectiveness ratio;Country;Crossover Design;design;Diphosphates;Dose;Dryness;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;empowerment;emtricitabine;Enrollment;Ensure;Ethnic Origin;Event;evidence base;Evidence based intervention;FDA approved;Feedback;Focus Groups;follow-up;Fumarates;Gays;Geography;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;incremental cost-effectiveness;Individual;Infection;Injectable;Injections;innovation;Intervention;intervention cost;Leadership;Link;Measures;Mediator;men who have sex with men;mHealth;mobile application;mobile computing;Modality;Modeling;Modification;multidisciplinary;Oral;Pamphlets;Participant;Patients;Performance;Persons;Pharmaceutical Preparations;pill;Pilot Projects;Population;Population Heterogeneity;pre-exposure prophylaxis;preference;primary outcome;provider communication;Race;Randomized;Randomized, Controlled Trials;recruit;Regimen;Resources;Self Efficacy;Site;Southern Africa;Spanish;Spanish/English;Spottings;support tools;System;Target Populations;Tenofovir;Testing;Text Messaging;Time;tool;two way texting;United States;uptake;usability;Waiting Lists;web site;Work;young adult;young woman;Youth

PROJECT_TITLE: RP3 PrEP Choice


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT We propose to study diverse phenotypic, metabolic pathways and low-frequency variants to identify new high- effect and actionable targets for AD. We will develop methods and validation data which will enhance the interpretability of AD variants across the allele-frequency spectrum. This is an essential step towards interpretation of an individual’s AD risk and enabling identification of new target genes and pathways.

PI_NAMEs: MONTGOMERY, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;ATAC-seq;Behavior;biobank;Biological Assay;Biological Factors;Biological Markers;Biological Process;Brain;brain cell;Brain imaging;brain tissue;Cardiovascular Diseases;Cell Line;cell type;Chromatin;Chromosome Mapping;Cognitive deficits;cognitive function;computerized tools;Data;Data Set;Databases;deep sequencing;Dementia;Development;Diabetes Mellitus;Disease;Elderly;experience;Frequencies;functional genomics;Gene Expression Regulation;Gene Frequency;Genes;Genetic;genetic variant;genome analysis;genome wide association study;genome-wide;genomic data;Genotype-Tissue Expression Project;Goals;Guidelines;Immunity;Impaired cognition;improved;Individual;large datasets;Link;lipid metabolism;Maps;Medical;Mendelian randomization;Metabolic Pathway;Methods;Molecular;molecular phenotype;mortality;Nerve;Neurodegenerative Disorders;next generation;novel;Pathway interactions;Phenotype;phenotypic data;Process;programs;public health relevance;Publications;Quantitative Trait Loci;rare variant;Reporter;Research;Resolution;Resources;Risk;Role;Senile Plaques;Signal Transduction;Site;sleep pattern;Source;Structure;Talents;Techniques;Testing;Therapeutic Intervention;Time;Tissues;trait;transcriptome;transcriptome sequencing;Validation;Variant;Work;working group

PROJECT_TITLE: Mapping Molecular and Phenotypic Interactions in Alzheimers Disease

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Prevalent chronic diseases, such as metabolic syndrome, exhibit enhanced toxicity in response to environmental exposures, however, the molecular mechanisms of susceptibility remain unknown. This proposal mechanistically investigates impaired inflammatory resolution in metabolic syndrome following inhalation of nanoparticles via unique nanoparticle-biomolecule interactions, decreases in specialized pro-resolving mediator signaling, and disrupted fatty acid metabolism. The elucidation of these susceptibility mechanisms related to impaired inflammatory resolution will increase our understanding of exposure-induced diseases and support the development of new therapeutic strategies.

PI_NAMEs: SHANNAHAN, JONATHAN HENRY (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Address;Carbon Black;Chronic Disease;cohort;Data;Development;Disease;Disease Progression;disorder prevention;Environmental Exposure;environmental particulate;Evaluation;Exhibits;Exposure to;fatty acid metabolism;Glycerol;Goals;Health;Health protection;Histologic;Impairment;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Inhalation;Inhalation Exposure;inhibitor;innovation;Kinetics;Knowledge;Laboratories;lipid metabolism;lipidomics;Lipids;Lipolysis;Lung;Lung Lavage Fluid;mass spectrometric imaging;Mediating;Mediator;Metabolic syndrome;Metabolism;metal oxide;Modification;Molecular;mouse model;Mus;nanoparticle;nanoparticle exposure;nanosized;novel;novel therapeutic intervention;Omega-3 Fatty Acids;Particulate;Particulate Matter;Pathologic;Pathway interactions;Pattern;pharmacologic;Population;Predisposition;Prevention strategy;Process;Production;Progressive Disease;Proteomics;Public Health;Pulmonary Surfactant-Associated Protein D;receptor;receptor expression;Research;Resolution;response;Risk Assessment;Role;Safety;Signal Transduction;Silver;Sphingomyelins;Surface;targeted treatment;Testing;Therapeutic Intervention;therapy development;Toxic effect;treatment strategy

PROJECT_TITLE: Compromised Resolution of Inflammation following Nanoparticle Exposure in Metabolic Syndrome

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This project will create a new non-invasive methodology to measure coronary fractional flow reserve (FFR) based on magnetic resonance Imaging (MRI) and computational fluid dynamics (CFD). FFR a metric to assess the functional severity of coronary lesions and treatment decisions based on FFR rather than angiography severity have been shown to improve patient outcomes. Image acquisition and image display methodology will developed in conjunction with the Siemens Healthineers Medical Imaging Technology and MRI Collaboration Divisions.

PI_NAMEs: OSHINSKI, JOHN N (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Anatomy;Angiography;Angioplasty;Arteries;biomedical imaging;Blood flow;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiology;Catheterization;Cause of Death;Clinical;clinical implementation;Clinical Trials;Collaborations;Complex;computational pipelines;computer science;Computing Methodologies;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Artery Ischemia;coronary lesion;Coronary Stenosis;Development;Diagnostic;Distal;Environment;Equation;Etiology;Event;experimental study;Geometry;Goals;Guidelines;Heart Diseases;Image;image processing;Imaging technology;improved;In Vitro;in vivo;Individual;Industry;Intervention;Ionizing radiation;Joints;Knowledge;Laboratories;Lesion;Liquid substance;Magnetic Resonance Imaging;Mathematics;Measurement;Measures;Medical Imaging;Methodology;Methods;Modeling;Motion;Multi-Institutional Clinical Trial;Non-Invasive Lesion;novel;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Physiological;pressure;Procedures;Protocols documentation;Radiology Specialty;reconstruction;Resources;Rest;Roentgen Rays;Severities;simulation;Stenosis;Stents;Stress;Study models;Techniques;Technology;Testing;Time;tool;United States;Universities

PROJECT_TITLE: Coronary Fractional Flow Reserve Determined Using MRI and CFD


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

PHR: Studies from the Mamula and Kibbey laboratories have detailed the novel biochemical properties of self proteins that amplify both autoimmunity and alterations in beta cell metabolism, biomarkers for pancreatic beta cell health and subsequent immune responses. This proposal will examine the specific posttranslational protein modifications that emerge in inflamed beta cells characteristic of T1D. We will examine the consequences of how inflammatory processes may alter protein modifications, autoimmune B and T cell responses, as well as glucose sensing and insulin release by beta cells.

PI_NAMEs: KIBBEY, RICHARD G;MAMULA, MARK J (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affect;Antibodies;Appearance;Asparagine;Aspartic Acid;Attention;Autoimmune;Autoimmune biomarker;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B-Lymphocytes;Beta Cell;Binding Sites;Biochemical;Biological;Biological Assay;Biological Markers;Carbon;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Chronic;Citrulline;Clinical;cytokine;Data;deamidation;Development;early onset;Enzymes;exosome;Exposure to;Extracellular Space;Functional disorder;Glucokinase;Glucose;Glycolysis;glycosylation;Health;Human;Human body;human induced pluripotent stem cells;Immune response;Immunity;immunogenic;Immunologic Markers;In Vitro;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Ions;islet;Islets of Langerhans;Isoaspartic Acid;Label;Laboratories;Link;Location;Maps;Mass Spectrum Analysis;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mind;mitochondrial metabolism;Modification;molecular modeling;Mus;neoantigens;non-diabetic;novel;Outcome;oxidation;Pancreas;Pathology;Pathway interactions;Patients;Peptides;Peripheral;Pharmacologic Substance;Phosphorylation;Pilot Projects;Positioning Attribute;Post-Translational Protein Processing;Process;Production;Property;Protein Chemistry;Protein Isoforms;Proteins;Proteome;Proteomics;Reaction;Reactive Oxygen Species;repaired;response;Sentinel;Serology;Shapes;Site;stable isotope;Stable Isotope Labeling;Stress;Structure;Structure of beta Cell of islet;T cell response;T-Lymphocyte;Technology;Therapeutic;Time;Tissues;Universities;Work

PROJECT_TITLE: Posttranslational Neoantigens in Autoimmunity and Metabolism in T1D


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent and Young Adult;Adolescent Medicine Trials Network;Age;AIDS prevention;antiretroviral therapy;arm;Behavioral;Biological;Biological Markers;Black race;care outcomes;care systems;Caring;children of color;Clinic;community partnership;consistent condom use;Consultations;Continuity of Patient Care;cost;Cost Effectiveness Analysis;Data;Development;Discrimination;Drops;economic need;Economics;Education;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation study;Employment;Environment;Epidemic;ethnic disparity;evidence base;experience;food insecurity;Gender;gender affirmation;gender diverse;Geography;Goals;Grant;Health;health equity;Healthcare;Heterogeneity;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;HIV Seronegativity;HIV/AIDS;Homelessness;Housing;Human immunodeficiency virus test;Hybrids;implementation framework;implementation process;Imprisonment;improved;Income;Individual;Inequity;insight;Intervention;Latinx;Lawyers;Leadership;Legal;Legal system;Link;Measures;Mediator;Mentors;Modeling;multi-component intervention;multidisciplinary;Names;Outcome;Participant;Patient Self-Report;peer;peer support;perceived discrimination;Personal Satisfaction;Persons;Population;pre-exposure prophylaxis;prevention service;process evaluation;programs;prospective;Race;racism;Randomized;Recording of previous events;recruit;Research;Resources;Risk;scale up;Schools;Services;Sex Behavior;sexual risk behavior;sexual risk reduction;Site;social determinants;social health determinants;System;theories;therapy design;transgender;Translations;transmission process;treatment effect;Treatment outcome;Trust;United States;uptake;Viral;Viral Load result;Work;Youth

PROJECT_TITLE: RP4 LEAP


ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a disease that is caused by structural changes in pulmonary arteries (PA) that promotes high pulmonary arterial blood pressure and ultimately right heart failure and death. We recently published that the expression of a novel gene, galectin-3 (Gal-3) regulates the remodeling of PA in experimental animal models of PAH, and showed that Gal-3 inhibitors and genetically modified rats lacking Gal- 3 are protected from PAH. Building upon these previous findings, the major goal of our new proposed studies is to identify cell specific mechanisms by which novel genes control the expression and function of Gal-3 in PA.

PI_NAMEs: BARMAN, SCOTT A;FULTON, DAVID J (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Apoptosis;Attenuated;Binding;Binding Sites;Blood flow;Capsid;Cell Nucleus;Cell Proliferation;cell type;Cells;Cessation of life;Characteristics;Chimeric Proteins;Coculture Techniques;Complex;Data;Development;Diagnosis;digital;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;Endothelial Cells;Endothelium;Epigenetic Process;Experimental Animal Model;experimental study;extracellular;Extracellular Space;Fibrosis;Funding;Galactose Binding Lectin;Galectin 3;Gene Modified;Genes;Goals;Human;Hypertrophy;Hypoxia;In Vitro;in vivo;indexing;inducible Cre;Inflammation;inhibitor;Knock-out;Knockout Mice;loss of function;LoxP-flanked allele;Lung;magnetic beads;Measurement;Medial;Mediating;Mediator;Methylation;migration;Modeling;Mus;mutant;Nodal;novel;Nuclear;Pathogenesis;Pathologic;pharmacologic;Phenotype;prevent;Proliferating;promoter;Promoter Regions;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;pyrosequencing;Rattus;Regulation;Research;Resistance;Resolution;Ribonucleoproteins;right ventricular failure;Right ventricular structure;RNA Splicing;Role;Signal Pathway;small hairpin RNA;Smooth Muscle Myocytes;Sorting;symptom treatment;synergism;Systolic Pressure;Tamoxifen;Testing;Therapeutic;Time;treatment strategy;ultrasound;Up-Regulation;Vascular remodeling;Vascular resistance;Ventricular;Virus

PROJECT_TITLE: Galectin-3: A mediator of vascular remodeling in pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  This proposal aims to study small molecules that are capable of stimulating the activity of SIRT5 that regulates mitochondrial function by removing acyl modifications from a broad array of biological targets. Given its numerous roles in many different pathologies, a great deal of interest exists in targeting SIRT5 therapeutically by small molecules. In addition, SIRT5-specific modulators could provide valuable tools in deciphering in vivo functions and regulation of SIRT5.

PI_NAMEs: CEN, YANA  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acetylation;Achievement;Activation Analysis;activity-based protein profiling;age-related disease;Allosteric Regulation;analog;Apoptosis;Archaea;Binding;Binding Sites;Biochemical;Biogenesis;Biological;Biological Assay;Biological Process;Biology;Biophysics;Caloric Restriction;Calories;Calorimetry;Cardiac health;Cardiovascular Diseases;Catalytic Domain;cell growth regulation;Cell Physiology;Cells;cellular targeting;Chemicals;Complement;Coupled;Data;Deacetylase;Deacetylation;design;Detection;Development;Diabetes Mellitus;dihydronicotinamide;DNA Repair;Docking;Electrostatics;Enzyme Activation;enzyme activity;Enzyme Kinetics;Enzymes;experimental study;extend lifespan;Family;fly;Gene Dosage;Gene Silencing;Goals;halogenation;Health;Health Benefit;High Pressure Liquid Chromatography;Human;improved;in vitro Assay;in vitro testing;in vivo;innovation;insight;insulin secretion;Intake;interest;Investigation;Knowledge;Libraries;Ligands;Longevity;Mammals;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Mitochondria;model organism;Modification;Molecular;Mus;mutant;Nature;Neurodegenerative Disorders;Neurons;next generation;Niacinamide;nicotinamide-beta-riboside;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Organic Synthesis;Organism;Outcome;Pathology;Pharmaceutical Preparations;Photoaffinity Labels;Physiological;Play;preservation;Prevention;Protein Array;Proteins;Purine-Nucleoside Phosphorylase;rational design;Regulation;response;riboside;Role;scaffold;screening;Series;Sir2-like Deacetylases;SIRT1 gene;Sirtuins;Site-Directed Mutagenesis;small molecule;small molecule therapeutics;Specificity;Stimulus;Stress;structural determinants;Structure;Structure-Activity Relationship;synthetic peptide;Testing;Therapeutic;therapeutic candidate;Time;Titrations;tool;Tumor Suppressor Proteins;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Small molecule approach to activate human SIRT5

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Regenerative Medicine

PHR: PROJECT NARRATIVE Ductular reaction is a cellular response to liver injury that involves extensive proliferation of biliary epithelial cells (BECs) and can include regenerative plasticity between BECs and hepatocytes. This proposal will establish a deep functional and mechanistic understanding of how the transcription factor Sox9 regulates proliferation and cell identity during ductular reaction. Our studies will define fundamental gene regulatory networks involved in the pathophysiology of liver disease and identify targets for therapies aimed at restoring liver function in end stage liver disease.

PI_NAMEs: GRACZ, ADAM DAVID (contact)

PROJECT_TERMS: Acute;Adult;Alleles;Biliary;Binding;Biological Assay;Cartilage;Cell Differentiation process;Cell Proliferation;Cells;Cholestasis;Chromatin;Chronic;Cleavage Under Targets and Release Using Nuclease;Data;Development;Duct (organ) structure;end stage liver disease;Enhancers;Epigenetic Process;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Equilibrium;Esophagus;Exhibits;Functional disorder;functional genomics;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Goals;Hair follicle structure;Hepatocyte;Heterogeneity;Homeostasis;Human;Hybrids;Impairment;In Vitro;in vivo;in vivo Model;Injury;injury and repair;insight;intrahepatic;Intrahepatic bile duct;Knockout Mice;Knowledge;Liver;Liver diseases;Liver Failure;liver function;liver injury;Liver Regeneration;liver transplantation;Maps;Mediating;Modeling;mouse model;multiple omics;Mus;Natural regeneration;novel therapeutics;Organoids;Phenotype;Play;Population;Process;Proliferating;Reaction;regenerative;Regenerative capacity;Regenerative Medicine;Regulation;repaired;Reporting;response;Role;severe injury;single cell ATAC-seq;Specific qualifier value;stem cell function;stem cells;targeted treatment;Testing;therapeutic target;tissue regeneration;Tissues;transcription factor;transcriptome sequencing;transcriptomics;transdifferentiation;Transgenes

PROJECT_TITLE: Genetic regulation of ductular reaction in liver injury and regeneration

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nanotechnology;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE The placenta plays a critical role in fetal development and pregnancy health. We plan to study novel, nanovesicle-based communication pathways between placental and maternal tissues. These nanovesicles carry unique genomic signals to target cells, and may also participate in the protection of placental and maternal tissues against viral infections during pregnancy.

PI_NAMEs: SADOVSKY, YOEL  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Adult;Affect;Allografting;Apoptotic;Attenuated;Bathing;Biological;Biological Process;Biopsy;Blood;Bulla;Cell Line;Cell membrane;Cell Physiology;cell type;Cells;Chromosome 19;Circulation;Clinical;Communication;Cytomegalovirus;Data;Decidua Basalis;design;Diagnostic;Dimensions;Disease;Distant;DNA Viruses;Endocrine;Endosomes;engineered exosomes;Environment;Equilibrium;Excision;Exhibits;exosome;experimental study;fetal;Fetal Development;Fetal Growth Retardation;Fetal Tissues;Fetus;Functional disorder;Gases;Genomics;Glycoproteins;Growth Factor;Health;HIV;Hormones;Human;human pathogen;Immune signaling;Immunologics;in vivo;Infection;Injury;interest;Invaded;Investigation;Knowledge;lipidomics;Maternal Physiology;Mediating;Metabolic;microRNA delivery;MicroRNAs;microvesicles;migration;Modeling;Mothers;Mus;nano;nanoparticle;nanoscale;nanosensors;nanovesicle;novel;Nutrient;Organ;Organism;paracrine;Pathway interactions;peptide hormone;Physiological;Physiological Adaptation;Placenta;Placental Biology;placental trophoblasts;Plasma;Play;Positioning Attribute;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy disorder;pregnancy health;Pregnant Women;premature;Premature Birth;prevent;Process;Proteins;Proteomics;Regulation;Research;resilience;Resistance;RNA Viruses;Role;Rubella;Signal Transduction;Simplexvirus;steroid hormone;Steroids;Termination of pregnancy;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;trafficking;Transgenic Mice;trophoblast;uptake;Vesicle;Viral;Viral Physiology;viral resistance;Virus Diseases;Waste Products;Work

PROJECT_TITLE: Exosome Based Placental Maternal Communication

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Arthritis;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Osteoarthritis

PI_NAMEs: DHONG, CHARLES B. (contact)

PROJECT_TITLE: Restoring the fixed charge density of damaged articular cartilage through synthetic aggrecan mimics


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Substance Misuse;Teenage Pregnancy;Women's Health Research

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;Adolescent Medicine Trials Network;Advanced Development;Age;aged;AIDS prevention;arm;assigned female at birth;Attitude;Benefits and Risks;cis-female;Clinical Research;condoms;Contraceptive Agents;Contraceptive methods;Data;design;Development;Drug Delivery Systems;Drug Interactions;Drug Kinetics;Drug Targeting;Ensure;Epidemic;Evaluation;experience;experimental study;first-in-human;Gender;gender affirming hormone therapy;gender minority group;gender minority status;gender minority youth;Health Benefit;health disparity;Healthcare Systems;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;HIV/AIDS;improved;In Vitro;Injectable;Injections;innovative technologies;Intervention;Interview;Leadership;Levonorgestrel;Licensing;Licensure;Menstruation;Mission;Modality;Modeling;nonhuman primate;novel;novel therapeutics;Oral;Ovulation Inhibition;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phase;pre-exposure prophylaxis;preclinical study;preference;Pregnancy;Pregnancy in Adolescence;pregnancy prevention;prevent;Prevention;product development;Public Health;Rattus;Reporting;reversible contraceptive;Risk;Safety;safety assessment;Sampling;sex;Sexual and Gender Minorities;sexual and reproductive health;sexual minority group;sexual minority youth;Signal Transduction;Site;social;Subcutaneous Injections;success;Technology;technology development;Time;transgender;transgender men;transmasculine;United States;uptake;Youth

PROJECT_TITLE: RP5 MPT Study


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dietary Supplements;Genetics;Microbiome;Nutrition;Pediatric;Rare Diseases

PHR: Public Health Relevance Statement: The human gastrointestinal tract is home to a large number of functionally diverse microbes that influence the chemicals circulating in our body. Inborn errors in metabolism are human genetic diseases where toxic chemicals accumulate to high levels in the blood. In this proposal, we will identify beneficial microbes isolated from the guts of healthy humans and develop approaches to use these microbes as probiotics to treat inborn errors in metabolism.

PI_NAMEs: DODD, DYLAN  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Alternative Therapies;Amino Acids;Bacteria;bacterial genetics;beneficial microorganism;Biochemical;Biochemistry;Blood;Chemicals;Defect;Development;Diet;Distal;Drug Metabolic Detoxication;Engineered Probiotics;Enzymes;Foundations;Future;Gastrointestinal tract structure;Gene Cluster;Gene Combinations;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Gnotobiotic;Goals;gut bacteria;gut microbes;gut microbiota;Hereditary Disease;Home;host microbiota;Human;Human body;Human Genetics;Immune;In Vitro;Individual;Injectable;insight;Investigation;Libraries;Measures;Mediating;member;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Microbe;microbial;microbiome;microbiota;Modeling;mouse model;Mus;Mutation;novel;novel strategies;Oral Administration;Organ;Pathway interactions;Patients;Peptides;Phenylalanine;Phenylalanine Metabolism Pathway;Phenylketonurias;Plasma;Poison;Polysaccharides;Probiotics;public health relevance;Regulatory Pathway;Resources;Role;Running;side effect;Small Intestines;stable isotope;stool sample;Testing;transcriptome sequencing;transcriptomics;unpublished works;Work

PROJECT_TITLE: Microbiota-based probiotics to treat inborn errors in metabolism

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The broad objective of this research proposal is to advance our understanding of thyroid physiology through study of genetic defects at key regulatory processes. The project involves three aims: (1) expand the study of newly identified genetic defects that affect thyroid physiology; (2) characterize the mechanism of resistance to thyrotropin caused by mutations in a primate specific non-coding DNA sequence; (3) determine the effectiveness of combined gene therapy and thyroid hormone analogue administration as a preclinical treatment for monocarboxylate transporter 8 deficiency. Elucidating the mechanisms of these conditions will result in unprecedented knowledge of thyroid physiology and provide scientific rationale for targeted treatments.

PI_NAMEs: BIANCO, ANTONIO C;DUMITRESCU, ALEXANDRA MIHAELA;REFETOFF, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Acids;Affect;Allan-Herndon-Dudley syndrome;analog;Area;boys;Brain;Cardiac;chromosome 14 uniparental disomy syndrome;Chromosomes;Clinical Skills;cofactor;cognitive function;Collaborations;combination gene therapy;Combined Modality Therapy;Complementary DNA;Complex;CRISPR/Cas technology;Defect;Dependovirus;Diagnosis;Dimerization;Disease;DNA Sequence;effectiveness evaluation;Family;Functional disorder;Funding;Gene Combinations;Gene Dosage;Gene Expression;Gene Expression Regulation;gene therapy;Genes;Genetic;Genetic study;genome editing;Genomic Imprinting;Goals;Gorilla gorilla;Grant;Hereditary Disease;hormone analog;Hormone Responsive;Human;Impairment;improved;In Vitro;in vivo;Individual;Inherited;innovation;insight;Iodide Peroxidase;Knockout Mice;Knowledge;Laboratories;LDL-Receptor Related Protein 2;Link;loss of function;Lymphocyte;Mediating;Membrane;Metabolic;Methylation;MicroRNAs;Molecular;Mus;mutant;Mutation;novel;Organ;Organoids;Pathway interactions;Patients;Peripheral;Phenotype;Physiological;Physiology;pre-clinical;Pre-Clinical Model;Primates;Process;programs;Proteins;Puberty;Publications;Research;Research Personnel;Research Proposals;Resistance;resistance mechanism;Role;Sampling;Satellite Viruses;selenoenzyme;Serum;Short Tandem Repeat;success;Syndrome;Tandem Repeat Sequences;Technical Expertise;Techniques;Technology;Testing;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyrotoxicosis;Thyrotropin;Tissues;tool;Transplantation;Untranslated RNA;Variant;X Chromosome

PROJECT_TITLE: Thyroid Physiology Studies of Inherited Disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE: Standard models of Alzheimer’s disease (AD) may accurately describe the progression of some, but not all individuals – particularly if heterogeneity reflects disease subtypes with separate etiologies. The goal of the current project is to improve our understanding of AD etiology by defining genetic risk along multiple dimensions defined by different biological pathways, and determining whether this gives rise to variability in biomarker and cognitive profiles. Characterizing the variability of AD etiology will inform efforts aimed at developing and assessing targeted therapeutic intervention and disease prevention.

PI_NAMEs: ELMAN, JEREMY A (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: abeta accumulation;abeta deposition;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Atrophic;Automobile Driving;Baltimore;biobank;Biological;biological heterogeneity;Biological Markers;Biological Process;Biology;biomarker panel;Brain;California;career development;Characteristics;Cognition;Cognitive;cognitive neuroscience;cohort;Collaborations;Complement;Complex;Control Groups;Coupled;Data;Deposition;Dimensions;Disease;disorder prevention;disorder subtype;Environment;Etiology;Event;Failure;Future;Genes;Genetic;Genetic Databases;Genetic Heterogeneity;Genetic Identity;Genetic Predisposition to Disease;Genetic Risk;genetic risk assessment;genome wide association study;genome-wide;Goals;Grouping;Heterogeneity;Image;Impaired cognition;improved;Individual;infancy;Interdisciplinary Study;Intervention;Intervention Trial;K-Series Research Career Programs;Knowledge;large scale data;Link;Longitudinal Studies;Measures;Memory impairment;Mentors;Methodology;Modeling;Molecular Genetics;Monitor;Nerve Degeneration;neuroimaging;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;polygenic risk score;Positioning Attribute;precision medicine;Process;programs;Psychiatry;Research;research facility;Research Personnel;Risk;risk variant;Signal Transduction;skills;Source;System;targeted treatment;tau Proteins;Testing;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Training;treatment group;treatment trial;Twin Studies;Universities;Vietnam;Work

PROJECT_TITLE: Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneity

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: The proposed research is relevant to public health because it will result in the development of a user friendly, rapid HIV self-test for detecting early stages of acute infection and viral rebound in individuals receiving antiretroviral therapy. Thus, the proposed research is relevant to NIAID's mission by advancing HIV research and improving human health through the development of new diagnostics tools to improve the diagnosis and clinical management of HIV-infected individuals.

PI_NAMEs: LILLEHOJ, PETER B (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acute;acute infection;Antibodies;antiretroviral therapy;Architecture;Bathing;Biological Assay;Blood;Blood specimen;Chronic;Clinical;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;comparative;Consumption;cost;Data;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;diagnostic value;Early Diagnosis;Effectiveness;effectiveness evaluation;Engineering;Enzymes;Evaluation;FDA approved;Freeze Drying;General Population;Generations;Hand;Health;high reward;high risk;HIV;HIV Antigens;HIV Infections;HIV-1;Home;Human;Human immunodeficiency virus test;improved;Individual;innovation;instrument;instrumentation;isothermal amplification;Laboratories;Lateral;lateral flow assay;lateral line;Life;Measurement;Methods;Mission;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;novel diagnostics;Nucleic Acid Amplification Tests;nucleic acid detection;Nucleic Acids;operation;Outcome;Patient Monitoring;Patients;Performance;Persons;Phase;Population Heterogeneity;pre-exposure prophylaxis;Preparation;Procedures;prototype;Public Health;rapid test;Reaction;Refrigeration;Research;RNA;RNA amplification;RRM2 gene;Saliva;salivary assay;Sampling;SARS-CoV-2 antigen;self testing;Sensitivity and Specificity;smartphone application;Specimen;Speed;Techniques;Technology;Telephone;Temperature;Test Result;test strip;Testing;Time;transmission process;usability;user-friendly;viral detection;Viral Proteins;viral rebound;viral RNA;viral transmission;Water

PROJECT_TITLE: CRISPR-Cas13-based rapid HIV-1 test


NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: NARRATIVE Age is the greatest risk factor for a host of totally distinct chronic diseases but the mechanistic basis for this shared risk and its continued increase as a function of age is not well understood. This proposal focuses on caloric restriction, a dietary intervention that slows aging and age-related disease in diverse species including primates. Studies are designed to investigate the mechanisms by which CR lowers disease incidence and progression and enhances survival in the long-lived and highly translational species.

PI_NAMEs: ANDERSON, ROZALYN M. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adipose tissue;Adult;Age;Age of Onset;age-related disease;Aging;aging related;Animals;Autopsy;Biology of Aging;Caloric Restriction;Cardiovascular Diseases;Cells;Child;Chromatin;Chronic Disease;Clinical;clinical application;Clinical Data;cohort;Computer Models;cytokine;Data;density;design;detection of nutrient;Diabetes Mellitus;Diet;Dietary Intervention;dietary restriction;Disease;end of life;Epigenetic Process;Female;Fibroblasts;functional decline;Gene Expression;Genetic Transcription;Growth;Hand;Health;health record;healthspan;Histology;Homeostasis;Human;human old age (65+);improved;Incidence;indexing;Inflammation;Inflammatory;insight;Intervention;Life;Link;lipid metabolism;lipidomics;Lipids;Liver;Logistic Regressions;Longevity;Longitudinal Studies;Macaca mulatta;male;Malignant Neoplasms;Malnutrition;Mammals;Messenger RNA;Metabolic;metabolic imaging;Metabolism;metabolomics;MicroRNAs;Molecular;Molecular Profiling;Monkeys;Morbidity - disease rate;mortality;Nerve Degeneration;nonhuman primate;novel;Outcome;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;Physical Function;Physiological;Physiology;Population;Post-Translational Protein Processing;Primates;Process;programs;Proteome;Proteomics;Publishing;random forest;Randomized;recruit;Regulation;Research;Resolution;response;Rhesus;Risk Factors;risk sharing;RNA;Role;Sampling;Serum;Signal Transduction;Skeletal Muscle;Specimen;Statistical Models;System;Techniques;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;translational model;Whole Organism;Wisconsin;Work;Yeasts

PROJECT_TITLE: Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: HIGHTOW-WEIDMAN, LISA B (contact)

PROJECT_TERMS: Address;Adherence;Administrator;Adolescent and Young Adult;Adolescent Medicine Trials Network;Adoption;Age;AIDS prevention;antiretroviral therapy;arm;Behavior;Behavior Therapy;Behavioral;behavioral disinhibition;Biological Markers;Bisexual;Caring;Characteristics;cisgender;Clinic;Clinical;Cocaine;Cognitive;Cognitive Therapy;Communities;Competence;condomless anal sex;Consultations;cost effectiveness;cost estimate;Counseling;Depressed mood;depressive symptoms;design;Development;Distress;economic impact;ecstasy;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;evidence base;Evidence based intervention;experience;Feedback;Feeling;field study;Funding;Gays;Geography;Health;Heterosexuals;HIV;HIV risk;HIV/AIDS;HIV/STD;Hybrids;implementation evaluation;implementation strategy;improved;Individual;Intervention;intervention delivery;intervention effect;Interview;Leadership;life time cost;Maintenance;Manuals;Measures;Mediating;Mediator;men who have sex with men;Mental Depression;Methamphetamine;Methods;Modeling;Motivation;multidisciplinary;non-drug;Outcome;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;pilot trial;pleasure;pre-exposure prophylaxis;Prevalence;prevention service;Primary Care;primary outcome;Professional counselor;Psychological reinforcement;psychosocial;Public Health;Quality-Adjusted Life Years;Random Allocation;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;relapse prevention;Reporting;Research;Resources;response;Risk;Risk Reduction;satisfaction;secondary outcome;Secure;sex;Sex Behavior;sexual risk behavior;sexual risk reduction;Sexual Transmission;sexually active;Site;skills;standard of care;Stimulant;stimulant use;Structure;substance use;substance use treatment;Testing;therapy adherence;Training;Training Activity;translational impact;Translations;transmission process;treatment as prevention;treatment services;United States;United States National Institutes of Health;Unsafe Sex;uptake;Urinalysis;Viral;Viral Load result;virtual

PROJECT_TITLE: RP7 Impact


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This project aims to improve public health by developing a novel approach to guide diverse women at high risk of breast cancer toward the adoption of risk-management behaviors, which may include enhanced surveillance routines, preventive surgeries, and medications. We will develop and test the feasibility of an intervention that involves patient navigators interacting with individual patients over an extended period to offer information about breast cancer risk and risk-management options, shape beliefs about breast cancer risk, provide emotional support for risk-related coping, connect women with specialists who can provide personalized information and risk-specific care, and address financial and other practical barriers to medical care. The project is responsive to NCI’s mission and PAR-19-309 because it will lay the groundwork for an innovative behavioral approach to cancer prevention and control among diverse high-risk populations.

PI_NAMEs: PADAMSEE, TASLEEM J (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Acute;Address;Adopted;Adoption;Baseline Surveys;Behavior;Behavioral;Belief;Benchmarking;Biometry;Black race;black women;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Magnetic Resonance Imaging;Cancer Control;cancer prevention;cancer risk;Caring;clinical care;Communication;coping;cost effective;Counseling;Data;Daughter;Decision Making;design;Diagnostic;Dimensions;Early Diagnosis;Emotional;evidence base;Evidence based practice;experience;Face;Family;feasibility testing;Funding;gaps in access;Genetic;Genetic Predisposition to Disease;Goals;Health;Health Personnel;Health Psychology;Health Services Accessibility;Hereditary Malignant Neoplasm;high risk;high risk population;High Risk Woman;improved;individual patient;Information Management;Inherited;innovation;insight;Intervention;Intervention Trial;Interview;Knowledge Management;Link;loved ones;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Medical Genetics;member;Methods;Minority Women;Mission;Morbidity - disease rate;mortality;Mothers;National Comprehensive Cancer Network;novel strategies;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;patient navigation;patient navigator;Patient Representative;Persons;Pharmaceutical Preparations;population based;Population Heterogeneity;Predisposition;prevent;Preventive;preventive intervention;primary care provider;Process;programs;Provider;Public Health;Race;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Research;Resolution;Resources;Risk;Risk Management;Risk Reduction;Sampling;screening;Screening for cancer;screening program;Services;Shapes;Sister;Site;Social Network;socioeconomics;Specialist;standard of care;Structure;Surveys;System;Testing;therapy design;treatment arm;White Women;Woman

PROJECT_TITLE: Developing a Patient Navigation Intervention to Improve Risk Management among Women at High Risk of Breast Cancer

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Patient Safety

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Program Director/Principal Investigator (Sevrioukova, Irina F.): Project Narrative Human CYP3A4 is the major drug-metabolizing enzyme with extreme substrate promiscuity and complex allosteric behavior. Xenobiotic-induced inhibition and catalytic activation in CYP3A4 could lead to drug-drug interactions, chemical toxicity and therapeutic failures. This project investigates both the inhibitory and activation mechanisms and focuses on the development of a structure-based pharmacophore for a potent inhibitor and elucidation of the allosteric regulation of CYP3A4 by natural and foreign compounds. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

PI_NAMEs: SEVRIOUKOVA, IRINA F (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: 3-Dimensional;Active Sites;Address;Affect;Affinity;Allosteric Regulation;analog;Area;Basic Science;Behavior;Binding;Biochemical;Biological Availability;Carcinogens;Catalysis;Characteristics;Chemicals;Clinical;clinically relevant;Comparative Study;Complex;Consumption;CYP3A4 gene;Data;design;Development;dietary;Docking;drug candidate;drug development;drug efficacy;Drug Interactions;drug metabolism;Drug Modulation;Drug Stability;Drug toxicity;Environmental Pollutants;Enzymes;Failure;Flavonoids;Funding;Generations;Goals;Health;Hepatitis C;Herbicides;Heterogeneity;HIV Protease Inhibitors;HIV/HCV;Human;improved;in silico;inhibitor;Insecticides;insight;Investigation;Ketoconazole;Kinetics;Knowledge;Label;Lead;Ligand Binding;Ligands;Liver Microsomes;Maps;Medicine;Metabolic;Metabolic Biotransformation;Metabolism;Modeling;Modification;Molecular;Molecular Conformation;NADP;novel;organ transplant recipient;oxidation;Peripheral;Pesticides;Pharmaceutical Preparations;Pharmacologic Substance;pharmacophore;Phenotype;Plasma;Principal Investigator;Process;programs;Proteins;rational design;Reaction;reconstitution;Research;Ritonavir;Role;Site;stoichiometry;structural biology;structural determinants;Structure;System;Testing;Therapeutic;therapeutic effectiveness;tool;Toxic effect;Toxicology;Translational Research;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Toxicological importance of CYP3A4 catalysis and inhibition


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: MUESSIG, KATHRYN E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent and Young Adult;adolescent HIV prevention;Adolescent Medicine Trials Network;AIDS prevention;behavioral clinical trial;Biometry;care outcomes;Caring;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;community partners;Cost Analysis;Data;data access;Data Analyses;Data Collection;data dissemination;data harmonization;data management;Data Security;Enrollment;Ensure;Epidemic;Epidemiologic Monitoring;epidemiological model;Epidemiology;Equity;Ethical Review;Evaluation;evidence base;Evidence based intervention;experience;Foundations;Funding;Future;Guidelines;HIV;HIV risk;HIV-infected adolescents;HIV/AIDS;Human;Human immunodeficiency virus test;improved;Individual;Information Systems;innovation;Institution;International;Intervention;Intervention Studies;Laboratories;Lead;Leadership;Management Information Systems;mathematical model;Medical;Mentorship;Modeling;North Carolina;Pathway Analysis;Persons;Policies;Positioning Attribute;Prevention;programs;Protocols documentation;Provider;Public Health;Publications;Reproducibility;Request for Applications;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;Risk;Science;Secure;Services;Site;Standardization;Statistical Data Interpretation;Statistical Methods;Statistical Models;Supervision;System;Technology;therapy development;Time;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: SDMC; Statistical Data Mgmt Core


NIH_SPENDING_CATS: Aging;Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative Dysfunction of the primary cilium, the sensory antenna projected from the surface of most mammalian cells, contributes to a plethora of human syndromic disorders. Promyelocytic leukaemia nuclear bodies (PML-NBs) are commonly accepted as the nuclear signaling hub that regulates diverse stress-induced cellular responses and senescence in particular. This proposal is designed to mechanistically evaluate a novel paradigm that stress-induced PLM-NB translocation of a ciliary protein FBF1 plays a decisive role in initiating senescence program, and FBF1 depletion effectively protects animals from senescence-associated frailty and pathologies in either naturally aged or radiation/chemotoxicity-induced senescence models.

PI_NAMEs: HU, JINGHUA  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Abbreviations;Acute Promyelocytic Leukemia;Address;Adenosine Diphosphate;Affect;age-related disease;aged;Aging;aging related;Animal Model;Animals;Apoptosis;Architecture;base;Binding;Binding Proteins;Biogenesis;Biology;Bromodomain;Cell Aging;Cell Nucleus;Cells;Cellular Stress;chemokine;Cilia;ciliopathy;cilium biogenesis;Clinic;Communication;comorbidity;Cues;Cultured Cells;cytokine;Data;design;Devices;Disease;drivers of aging;Embryonic Development;Enzymes;Epithelial Cells;Eukaryotic Cell;Exhibits;Fiber;Fibroblasts;frailty;Functional disorder;Genetic;Goals;Growth;Growth Factor;Guanosine Triphosphate Phosphohydrolases;healthspan;healthy aging;Heterogeneity;Homeostasis;Human;Human body;improved;in vivo;in vivo Model;Inflammatory;irradiation;Joubert syndrome;Life;life span;Link;Longevity;Malignant Neoplasms;Mammalian Cell;Modeling;Modification;Molecular;mouse model;Mus;Mutate;novel;novel strategies;novel therapeutics;Nuclear;Nuclear Protein;Nuclear Structure;old mice;Organ;overexpression;p53-binding protein 1;Pathogenesis;Pathology;Pathway interactions;Peptide Hydrolases;pharmacologic;Physiological;Play;prevent;Probability;programs;Proliferating;Proteins;Proteomics;Radiation;Regulation;Resources;response;Rodent Model;Role;Seminal;senescence;senescent cell;Sensory;Signal Transduction;Somatic Cell;Stress;Structure;Sumoylation Pathway;Surface;Therapeutic;Tissues;Toxic effect;TP53 gene;transcription factor PML;Tumor Suppression;tumorigenesis;Ubiquitin;Up-Regulation

PROJECT_TITLE: A novel cilium-to-nucleus axis promotes cellular senescence


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Lung;Organ Transplantation;Palliative Care;Patient Safety;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative This research has the potential to improve the lives of patients and caregivers affected by end-stage lung disease and facing the complex decision whether to undergo lung transplant by addressing their informational needs. Results from this study will provide a better understanding of priorities for quality of life outcomes from the perspective of patients and caregivers, which can help guide and improve clinician communication about the risks and benefits of lung transplantation and reduce decisional conflict for patients about whether to pursue lung transplant evaluation.

PI_NAMEs: HOLLIN, ILENE L. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Affect;Applied Skills;Bass;Benefits and Risks;career;career development;Caregivers;Caring;Cessation of life;Chronic Phase;Clinical;clinical decision-making;Clinical Trials;Communication;community engaged approach;community engaged research;Complex;Comprehension;Conflict (Psychology);Data;Decision Aid;Decision Making;Decision Theory;Dedications;design;Development;Development Plans;Diagnosis;disability;Drops;Evaluation;Exercise;exhaust;experience;Extramural Activities;Face;Family;Funding;Future;Goals;graft failure;Grant;Health;health communication;health related quality of life;Health Services;high risk;improved;Infection;Instruction;International;Interview;Knowledge;Lead;Life;Life Expectancy;Life Extension;Lung;Lung Diseases;Lung Transplantation;Measures;Medical;Mentors;Mentorship;Methods;mortality;Organ Donor;organ transplant rejection;Outcome;Outcome Measure;Outcomes Research;Pathway interactions;Patient Care;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Phase;Physicians;Play;post-transplant;preference;Process;Productivity;professor;programs;Prospective cohort;provider communication;pulmonary function;Qualitative Methods;Quality of life;randomized, clinical trials;Recording of previous events;recruit;Research;Research Personnel;Risk;Role;Sampling;Scientist;Social support;Socialization;Source;Structure;Surveys;Testing;theories;Therapeutic immunosuppression;Time;tool;Training;transplant centers;Transplant Recipients;Transplantation;Universities;Waiting Lists;willingness;Work

PROJECT_TITLE: Patient Priorities in Lung Transplant: Quality of Life Outcomes to Inform Decision Making

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Hematology;Maternal Health;Neurosciences;Nutrition;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed public health research will yield high-quality evidence on the role of intravenous iron in the treatment of iron-deficiency anemia in pregnancy in terms of reducing peripartum blood transfusion---a marker of severe maternal morbidity---and improving infant neurodevelopmental outcomes. If proven effective, safe and cost-effective, widespread use of IV iron in pregnancy will positively affect the health of not only over one million pregnant women diagnosed with iron-deficiency anemia in the U.S. annually but their offspring as well.

PI_NAMEs: TUULI, METHODIUS GAMUO (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: absorption;Adherence;Adverse reactions;Affect;Age Months;American College of Obstetricians and Gynecologists;Anemia;Blood Transfusion;Brain;burden of illness;Centers for Disease Control and Prevention (U.S.);Cesarean section;Clinical;clinical outcome assessment;Constipation;cost;cost effective;cost effectiveness;cost estimate;cost per quality-adjusted life year;Data;Developing Countries;Dextrans;Diarrhea;Dose;Double-Blind Method;Dyspepsia;effectiveness evaluation;experience;Ferritin;fetal;First Pregnancy Trimester;Frequencies;gastrointestinal;Growth and Development function;Health;Hemoglobin;improved;Incidence;incremental cost;India;Infant;Infusion procedures;Intravenous;Iron;iron deficiency;Iron deficiency anemia;iron supplementation;Iron-Dextran Complex;Learning;Low Birth Weight Infant;Magnetic Resonance Imaging;maternal morbidity;maternal outcome;Measures;Mental Depression;Meta-Analysis;Metallic Tastes;Molecular Weight;Mothers;multidisciplinary;Myelin;National Health and Nutrition Examination Survey;Nausea;Neonatal;neonatal outcome;neonate;neurodevelopment;offspring;Oral;Outcome;Outcome Study;Patients;Perinatal;pilot trial;Placebo Control;Pregnancy;Pregnant Women;Premature Birth;Prevalence;prevent;public health research;Publishing;randomized trial;Recommendation;Research Personnel;Risk;Role;Route;saccharated ferric oxide;Safety;Sample Size;Second Pregnancy Trimester;severe maternal morbidity;side effect;systematic review;Testing;Third Pregnancy Trimester;Water;Woman;women's diagnosis

PROJECT_TITLE: A Multicenter Randomized Trial of IV vs Oral Iron for Treating Iron-Deficiency Anemia in Pregnancy


NIH_SPENDING_CATS: Aging;Diabetes;Hematology;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative A better understanding of the bone marrow cells is fundamental to improving therapies for both blood and bone diseases. Bone weakening related to aging and diabetes has been linked with impaired production of osteoblasts (principal bone-making cells) and increased marrow fat formation. The current project builds on the new finding of a common progenitor cell for both bone and marrow fat cells, and tests the role of the common progenitor in bone aging and diabetic bone loss.

PI_NAMEs: LONG, FANXIN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adiponectin;Adult;Age;age related;age related changes;Aging;animal old age;ANXA5 gene;Apoptosis;Binding;Blood Cells;bone;bone aging;bone cell;Bone Diseases;bone loss;Bone Marrow;Bone Marrow Cells;bone mass;Bone Surface;Cell Lineage;Cells;chemokine;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Doxycycline;Fatty acid glycerol esters;Female;Forteo;Functional disorder;Genetic;Genotype;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic System;Heterogeneity;Homeostasis;Image;imaging study;Impairment;improved;in vivo;Knowledge;Label;leptin receptor;Life;Link;Lipids;male;Mammals;Marrow;Mesenchymal;Molecular;Monitor;Mus;Myeloproliferative disease;Names;Non-Insulin-Dependent Diabetes Mellitus;old mice;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Osteoporosis;osteoprogenitor cell;Pathogenesis;perilipin;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Physiological;Physiology;Production;progenitor;Proliferating;response;Reticular Cell;Role;single-cell RNA sequencing;skeletal stem cell;Source;stem cell biomarkers;stem cell differentiation;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;Tamoxifen;Technology;Testing;tibia

PROJECT_TITLE: Illuminating adipo-osteoprogenitors in the bone marrow

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Narrative A key challenge for the aging research community is to extend lifespan in tandem with healthspan (life with good health) so that the period of frailty and disability can be compressed. Here, we propose to examine the role of a specific cell population in lifespan and healthspan using our novel animal model along with a cutting-edge technology, single cell transcriptomics. This project is likely to provide a deeper understanding of aging and lay the foundation for the drug development to extend both lifespan and healthspan in old population.

PI_NAMEs: XU, MING  (contact)

PROJECT_TERMS: Acceleration;Age;Age related pathologies;age-related disease;aged;Aging;aging process;Animal Model;Automobile Driving;Autopsy;Biological Aging;burden of illness;Cause of Death;Cell Aging;cell type;Cells;cellular targeting;Chronic Disease;Chronology;Communicable Diseases;Communities;Coupled;Cytometry;Data;disability;Disease;Dissociation;drug development;Elderly;Elements;end of life;Estrogen Receptors;experience;extend lifespan;Foundations;frailty;Future;Goals;Health;Health Status;healthspan;Heart Diseases;Human;human old age (65+);Image;improved;in vivo;in vivo Model;indexing;Insulin Resistance;Intervention;late life;Life;life span;Malignant Neoplasms;middle age;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;multiple chronic conditions;Mus;novel;Obesity;old mice;Older Population;Pathologic;Pathway interactions;Patients;pharmacologic;Physical Function;Pilot Projects;Population;Process;promoter;Proteins;Quality of life;Research;Risk Factors;Role;senescent cell;Sex Differences;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Sorting;Stress;Syndrome;Tamoxifen;Technology;Testing;Time;Tissues;transcriptomics;Transgenic Mice

PROJECT_TITLE: Targeting p21-Highly Expressing Cells to Increase Lifespan and Healthspan in Old Age