NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pulmonary Hypertension

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The main focus of this research is to develop a novel computational imaging framework for free breathing dynamic MRI. The proposed framework will enable a novel free-breathing protocol for the comprehensive evaluation of the heart and lung. The protocol is expected to enable the early detection and management of pulmonary hypertension is subjects with pulmonary disorders.

PI_NAMEs: JACOB, MATHEWS  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Blood Preservation;blood pressure elevation;Breathing;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Cardiopulmonary;Cause of Death;Chronic Disease;Clinical;Compensation;computer framework;constriction;contrast enhanced;cost;Data;Data Set;data space;Development;Diagnosis;Early Diagnosis;Echocardiography;Evaluation;Failure;FDA approved;Functional Imaging;generative models;Health Care Costs;Heart;heart function;heart imaging;high risk;HIV;Image;imaging modality;improved;Individual;Interstitial Lung Diseases;Joints;journal article;Learning;Lung;Lung Diseases;lung imaging;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical Care Costs;Methods;Modality;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Myocardium;novel;Paper;Pattern;Perfusion;Population;prospective;Protocols documentation;Publications;pulmonary function;Pulmonary function tests;Pulmonary Hypertension;Radial;Recovery;Reproducibility;Research;Resolution;right ventricular failure;Right ventricular strain;Right ventricular structure;Risk;Scanning;Scheme;Scleroderma;Site;Slice;Stress;Structure;symposium;System;Testing;Thick;Thinness;Time;Treatment Efficacy;unsupervised learning;Validation;Vasodilator Agents;Vendor;ventilation;World Health Organization;X-Ray Computed Tomography

PROJECT_TITLE: Novel Computational Framework for Free-Breathing & Ungated Dynamic MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Disease

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Chronic liver disease is a major contributor to morbidity and mortality worldwide, in part because there are no therapies to delay progression or promote resolution of hepatic fibrosis, the end stage pathology of chronic liver disease. Activation of the blood clotting cascade is associated with chronic liver disease progression, but the specific mechanisms linking clotting factors to deposition of scar tissue (i.e., collagen) in the injured liver are poorly understood. The primary goal of this research proposal is to uncover precisely how blood clotting factors interact with collagen-producing cells in the injured liver so that new therapies can be designed to delay the progression of liver fibrosis in patients.

PI_NAMEs: POOLE, LAUREN G (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Agonist;Automobile Driving;Blood coagulation;Blood Coagulation Factor;Carbon Tetrachloride;career;Cell Physiology;Cells;chronic liver disease;chronic liver injury;Cicatrix;Clinical;Coagulation Process;Collagen;Deposition;design;Development;Discipline;Disease Progression;Event;Exogenous Factors;Factor VIIa;Factor XI;Factor XII;Foundations;Genetic;Goals;Hemostatic function;Hepatic Stellate Cell;Hepatology;hepatotoxin;In Vitro;in vivo;Inflammation;Intrinsic drive;Ligands;Link;Liver diseases;Liver Fibrosis;liver injury;Mediating;Membrane;Morbidity - disease rate;mortality;Mus;Mutant Strains Mice;Myofibroblast;new therapeutic target;novel;novel therapeutics;Outcome;PAR-1 Receptor;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phenotype;Play;programs;Prothrombin;Publishing;receptor;Research;Research Personnel;Research Proposals;Resolution;Role;Scheme;Signal Transduction;skills;Testing;Thrombin;Thromboplastin;Thrombosis;tissue injury;Tissues;Toxicology;translational study;Up-Regulation

PROJECT_TITLE: Novel mechanisms linking blood coagulation to liver fibrosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Research Narrative The overall goal of this proposal is to validate and disseminate anthropomorphic high-resolution physical phantoms and corresponding protocols for research in quantitative imaging and theranostics through rigorous single and multi-center studies.

PI_NAMEs: JHA, ABHINAV K (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3D Print;absorption;Academia;Address;Algorithms;Alpha Particles;Anatomic Models;Anatomy;Automobile Driving;Back;Cancer Center;cancer type;Clinic;Clinical;Collimator;Communities;Data;data sharing;Deposition;Dose;Evaluation;Feedback;Goals;Image;imaging capabilities;imaging modality;Imaging Phantoms;imaging science;imaging system;Imaging Techniques;Imaging technology;improved;Industry;innovation;instrument;interest;Isotopes;Kidney;Laboratories;Lead;Letters;Libraries;Liquid substance;Malignant Neoplasms;Manuals;Measures;Medical center;Memorial Sloan-Kettering Cancer Center;Methodology;Methods;Modeling;Multicenter Studies;National Institute of Biomedical Imaging and Bioengineering;novel;Organ;Outcome;Parents;Patient Care;Patients;Performance;Physicians;Physics;Plant Resins;Preparation;Printing;Protocols documentation;quantitative imaging;Radiation Tolerance;Radioactive;Radioisotopes;Radiopharmaceuticals;Radium;Reader;reconstruction;Reproducibility;Research;Research Personnel;Resolution;Sampling;Scanning;single photon emission computed tomography;Site;Standardization;Structure;Technology;Testing;theranostics;Tissues;tool;Training;Translations;Universities;uptake;Validation;validation studies;Washington

PROJECT_TITLE: Validation and dissemination of novel physical phantoms for quantitative theranostics research


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Public Health Relevance Statement: Photodynamic therapy (PDT), in combination with surgery, offers a potential locally curative treatment and has been demonstrated in clinical trials, including in malignant mesothelioma, to substantially prolong patient survival. In this translational project we will optimize singlet oxygen dosimetry instruments and novel phantoms for direct quantitative measurements of the major cytotoxic agent (excited-state singlet oxygen) generated in PDT, which could significantly improve the accuracy and hence efficacy of this modality, both for this particular clinical application and more generally in other tumor sites. Being fiberoptic based, the technology will be suitable for implementation in any tumor site that is accessible to PDT (interstitial, endoscopic, intraoperative).

PI_NAMEs: HADFIELD, ROBERT HUGH;ZHU, TIMOTHY C. (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;3D Print;absorption;Affect;Anatomy;attenuation;Biological;Biomechanics;biophysical model;Calibration;Clinical;clinical application;Clinical Research;clinical translation;Clinical Trials;clinically relevant;curative treatments;cytotoxic;Cytotoxic agent;Dermis;design;design and construction;Detection;Development;Dose;dosimetry;Epidermis;Fat emulsion;Feedback;Fiber Optics;Gel;Generations;Goals;Grant;Hemoglobin;Human;Image Analysis;imaging detection;Imaging Phantoms;imaging system;improved;in vivo;Ink;instrument;interstitial;Lasers;Libraries;Light;light scattering;Liquid substance;Location;luminescence;Lung;Malignant mesothelioma;Malignant Pleural Mesothelioma;Measurement;Measures;Mediating;Medical Imaging;Mesothelioma;minimally invasive;Modality;Monitor;National Institute of Biomedical Imaging and Bioengineering;Noise;novel;Operative Surgical Procedures;optical fiber;Optics;Outcome;Oxygen;Patients;Performance;performance tests;Pharmaceutical Preparations;phosphorescence;Photobleaching;Photons;Photosensitizing Agents;Phototherapy;Physiologic pulse;Pleura;Pleural;Pleural cavity;Pleural photodynamic therapy;Porfimer Sodium;Pre-Clinical Model;preclinical study;Property;Protocols documentation;protoporphyrin IX;prototype;public health relevance;PUVA Photochemotherapy;Reaction;Recipe;response;Sampling;Shapes;Signal Transduction;simulation;Singlet Oxygen;singlet state;Site;Solid;Specific qualifier value;stability testing;System;Techniques;Technology;technology development;Testing;Time;tissue phantom;Tissues;Treatment Efficacy;tumor;Uncertainty;Variant

PROJECT_TITLE: Optimizing singlet oxygen dosimetry for photodynamic therapy (PDT)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Tobacco use remains the leading cause of preventable death, and racialized and socioeconomic inequities in tobacco use and related diseases persist. Innovative public health policies to reduce neighborhood TRA equitably are needed, especially in preempted states. This study will be the first to evaluate whether use-based zoning tobacco control policies can be intentionally designed to decrease neighborhood tobacco retailer availability equitably: findings from this study may open the door for a new suite of policy tools that can promote tobacco control and health equity nationally.

PI_NAMEs: KONG, AMANDA  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Address;Adult;Advocacy;Alcohols;anti-cancer research;authority;Behavior;Black race;built environment;Censuses;Characteristics;Cities;City Government;Collaborations;cost;Cues;design;Disease;dissemination science;Endowment;Environment;Epidemiologic Methods;Equity;ethnic minority population;Exercise;Geographic Information Systems;Goals;Health;health equity;health inequalities;Health Policy;Hispanic;implementation outcomes;implementation science;improved;Industrialization;Inequity;innovation;Intervention;Interview;Knowledge;land use;Latino;Laws;Licensing;Local Government;Malignant Neoplasms;Marketing;Methods;Mission;Neighborhoods;Oklahoma;Outcome;Pattern;Persons;Play;Policies;Politics;Population;preempt;preventable death;Public Health;public policy on tobacco;racial disparity;racial minority population;Recommendation;Role;Scientific Advances and Accomplishments;Shapes;smoking prevalence;sociodemographics;socioeconomic disparity;socioeconomics;spatial epidemiology;Structure;Tobacco;tobacco control;tobacco products;tobacco regulation;Tobacco use;Tobacco-Related Carcinoma;tool;Travel;Trust;Youth

PROJECT_TITLE: Investigating the impact of local land use and zoning policies on equitably reducing tobacco retailer availability

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: KENNESAW

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: KENNESAW STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The diffuse optics technique holds promise as a bedside cerebral blood flow monitoring tool for screen, diagnosis and therapeutic management of many brain-related diseases. In this supplement, we will characterize and optimize the optical phantoms mimicking multilayered microvascular cerebral blood flow. We envision the phantoms will serve as a standard reference for daily calibration, performance evaluation and quality control, contributing to clinical translation of light-based microvascular flowmeter through wide dissemination.

PI_NAMEs: LEE, SEUNG YUP  (contact)

PROJECT_TERMS: 3D Print;absorption;Address;Administrative Supplement;arteriole;base;Benchmarking;Blood capillaries;Blood flow;Blood Vessels;Brain;Calibration;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Child;Clinical;clinical translation;Computers;Data;Diagnosis;Diameter;Diffuse;Dimensions;Disease;Engineering;Ensure;Equipment;Evaluation;fabrication;Faculty;Fiber;Flowmeters;Goals;Human;Imaging Phantoms;improved;In Vitro;India ink stain;infrared spectroscopy;Institution;Laboratories;Libraries;Light;Liquid substance;lithography;Measurement;Methods;Microfluidic Microchips;Microfluidics;millimeter;Modeling;Monitor;National Institute of Biomedical Imaging and Bioengineering;Noise;Optics;Parents;Particle Size;Performance;Physiological;polydimethylsiloxane;portability;Procedures;Property;Protocols documentation;prototype;Quality Control;Reference Standards;Reproducibility;Research Personnel;screening;Screening procedure;Short Waves;Sickle Cell Anemia;Signal Transduction;Spectrum Analysis;Standardization;stroke risk;success;System;Techniques;Technology;Technology Assessment;Temperature;Testing;Therapeutic;Thick;Tissues;titanium dioxide;tool;Tube;venule;Viscosity

PROJECT_TITLE: Optical Phantoms Mimicking Microvascular Cerebral Blood Flow (Supplement)


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Continuous monitoring of blood pressure can help the early diagnosis of developing cardiovascular disease, reveal short term blood pressure variations, and help the physician monitor the response to medication for hypertensive patients. Current industrial and academic technology development for continuous cuffless blood pressure has a primary focus on optical technologies which does not operate satisfactorily on darker skin tones and those with higher BMI. Our proposed efforts will directly address this critical limitation through development of a technology that will operate satisfactorily in communities of color.

PI_NAMEs: JAFARI, ROOZBEH  (contact);PETTIGREW, RODERIC I.

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;adverse outcome;Affect;African American;African American population;Age;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;Artificial Intelligence;artificial intelligence algorithm;Atherosclerosis;attenuation;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;Blood Volume;Body mass index;Calibration;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Characteristics;clinical decision support;Clinical Research;cohort;college;Color;Communities;Data;design;Detection;Development;Devices;Early Diagnosis;Effectiveness;Exercise;experience;Fatty acid glycerol esters;Fingers;health equity;hemodynamics;high body mass index;High Prevalence;Hospitals;Human;Hypertension;hypertensive;Imaging technology;indexing;Industrialization;insight;Intervention Studies;Investigation;Latinx;Legal patent;Light;Literature;machine learning algorithm;masked hypertension;Masks;Measurement;Measures;Melanins;Methods;Modality;Modeling;Monitor;monitoring device;multidisciplinary;Not Hispanic or Latino;novel;Obesity;Optics;Organ;outcome disparities;Participant;Patient Self-Report;patient subsets;Patients;Pattern;Penetration;people of color;Pharmaceutical Preparations;Photoplethysmography;Physicians;Physiologic pulse;Positioning Attribute;Posture;Prevalence;prevent;Pulse Pressure;Recording of previous events;recruit;Reduce health disparities;Regimen;Reporting;Research;response;Risk Factors;Science;sensor;sex;Signal Transduction;Skin;skin color;Sleep;smart ring;smart watch;social;Subgroup;Supination;Supine Position;System;Technology;technology development;technology validation;Texas;Time;Tissues;Translating;trend;Validation;Variant;wearable device;wearable sensor technology;Weight;Work

PROJECT_TITLE: A Smart Ring for Cuffless Blood Pressure to Reduce Health Disparities in People of Color

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-X(90)S]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SPICEWOOD

ORG_NAME: CLAIRVOYANT NETWORKS, INC.

ORG_STATE: TX

PHR: Project Narrative Falls are a major public health concern, especially for people living with dementia; yet precise and practical fall detection systems are lacking. This project will conduct both lab and field studies (n=168 participants) to assess the accuracy of Theora® 360, an innovative automated fall detection system that uses Ultra Wideband technology combined with motion sensors to detect falls and assess mobility changes, fall risk, and fall context among community-dwelling people living with dementia (PLWD). Usability studies will also be built in to help ensure that system components are user-friendly. Successful completion can provide a valuable resource for PLWD to pursue aging in place and for caregivers to advance care while reducing caregiving burdens.

PI_NAMEs: SYMONDS, SHELLEY L (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: 3-Dimensional;Accelerometer;Address;Age;Aging;aging in place;Algorithms;Alzheimer's disease related dementia;Big Data;Bluetooth;Businesses;care giving burden;care recipients;Caregiver Burden;Caregivers;caregiving;Caring;Categories;Characteristics;Clinical;Clinical Research;Clinical Sciences;Cognition;Collaborations;commercialization;Communication;Communities;community engagement;computer science;Data;data communication;data platform;Dementia;Detection;detection platform;Drops;Engineering;Ensure;Equilibrium;experience;fall injury;fall risk;falls;Feedback;field study;Gait;Gait speed;Home;Hospitals;Human;human subject;Impaired cognition;improved;improved mobility;innovation;Instruction;Interview;Laboratories;Location;Manikins;meter;mild cognitive impairment;Mission;Modeling;Monitor;Motion;motion sensor;Movement;national surveillance;Neighborhood Health Center;neural network;new technology;novel;older adult;Participant;Patient Self-Report;Patients;Pattern;Persons;Phase;Physical activity;Population;Prevalence;pro-aging;Protocols documentation;prototype;Psychosocial Factor;Public Health;Quality of life;Reaction Time;real world application;Recommendation;Records;Resolution;Resources;Risk;Risk Assessment;risk prediction;satisfaction;Sensitivity and Specificity;sensor;sensor technology;sociodemographics;Specificity;success;surveillance data;Surveys;System;Technology;Testing;Texas;Time;tool;Universities;usability;user-friendly;wearable sensor technology;wireless fidelity;Work

PROJECT_TITLE: Ultra Wideband Fall Detection and Prediction Solution for People Living with Dementia


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MANHATTAN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Adiponectin is a protein that circulates in high levels in the blood and which has known protective effects on the cardiovascular system. Aging impairs vascular function, but late-life exercise can reverse much of the vascular dysfunction related to advancing age. The overall goal of this application is to determine whether adiponectin plays a role in 1) the vascular dysfunction that occurs with advancing age, and 2) the ability of exercise training to promote vascular resiliency and reverse age-related vascular dysfunction.

PI_NAMEs: DELP, JUDY M (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acute;adiponectin;Adjuvant;Aerobic Exercise;Age;age related;aged;Aging;Agonist;antagonist;arterial remodeling;Arteries;Biomedical Research;Blood;Blood flow;blood pressure regulation;Blood Vessels;cardiac vasculature;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Ceramides;Coronary;Development;Disease;Elderly;Elements;endothelial dysfunction;Endothelium;Exercise;exercise training;Functional disorder;gain of function;Germ Lines;Goals;Impairment;improved;Inflammation;Knock-out;late life;life span;loss of function;Microvascular Dysfunction;middle age;mimetics;Mus;Myocardium;novel;Organ;pathological aging;pharmacologic;Phenotype;Prevention;promote resilience;protective effect;Proteins;Rattus;receptor;Reporting;Research Priority;resilience;Resistance;response;Risk Factors;Role;sedentary;senescence;Signal Pathway;Signal Transduction;Skeletal Muscle;Smooth Muscle;Sphingosine;Structure;Testing;therapeutic target;Training;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;Vasomotor;Work;young adult

PROJECT_TITLE: Role of Adiponectin in Reversal of Age-related Vascular Dysfunction

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Health Services;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE CIBMTR (Center for International Blood and Marrow Transplant Research) plays a unique and important role in facilitating clinical research in hematopoietic cell transplantation (HCT) and adoptive cellular therapy (ACT). It is committed to developing its Research Database in volume and scope, its statistical expertise, and its data sharing capabilities to meet the needs of investigators in a rapidly evolving field. This supplemental award will allow CIBMTR to build on the infrastructure made possible by support from U24-CA076518 to better understand patient outcomes and care journey related to gene therapy for sickle cell disease.

PI_NAMEs: PASQUINI, MARCELO C.;SHAW, BRONWEN  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Adoptive Cell Transfers;Agreement;American;Award;beneficiary;Blood;blood resource;Bone Marrow Transplantation;care burden;Cell Therapy;Clinical;Clinical Data;Clinical Research;Clinical Trials Network;Collaborations;Collection;Communication;Communities;Consent;Correlative Study;cost;Data;Data Analyses;Data Collection;Data Coordinating Center;data de-identification;data exchange;data infrastructure;data modeling;Data Protection;data resource;Data Set;data sharing;Data Sources;data submission;Databases;Decision Making;Dedications;design;Development;Disease;Disparate;electronic patient reported outcomes;Environment;follow-up;Funding;gene therapy;gene therapy clinical trial;Goals;Health;Health Care Costs;Health Services Accessibility;Hematology;Hematopoietic Stem Cell Transplantation;improved;improved outcome;Incentives;Infection;Information Systems;Infrastructure;innovation;Insurance;International;international center;Life Cycle Stages;Link;Longterm Follow-up;Maintenance;Malignant - descriptor;Manufacturer;Medicaid;Medicare/Medicaid;Methods;Minor;Modeling;Modification;National Cancer Institute;National Heart, Lung, and Blood Institute;Non-Malignant;novel;Observational Study;Outcome;Outcome Measure;Participant;Patient Care;patient engagement;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;pediatric patients;Persons;Play;Population;Positioning Attribute;prescription drug costs;Process;programs;prospective;protocol development;Registries;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Role;Secure;Sickle Cell Anemia;Solid Neoplasm;Supporting Cell;Surveys;System;systems research;Techniques;Testing;Therapeutic Studies;Transact;Transplant Recipients;treatment center;United States Centers for Medicare and Medicaid Services;United States Dept. of Health and Human Services;United States National Institutes of Health;usability;Validation

PROJECT_TITLE: A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research


NIH_SPENDING_CATS: Bioengineering;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative The goal of ChartGlucose4Moms: Characterizing, by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae study (aka, Glycemic Observation and Metabolic Outcomes in Mothers and offspring (GO MOMs) study) is to use early pregnancy glycemia to predict traditional late pregnancy GDM diagnosis and LGA birth weight. GO MOMs was designed to collect key data that will facilitate improved approaches for GDM screening in early pregnancy and inform future clinical trials of early GDM treatment.

PI_NAMEs: LEBLANC, ERIN S (contact);VESCO, KIMBERLY KRISTINE

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Adipose tissue;Affect;Age;Biological Markers;biomarker identification;Birth;Birth Weight;Brachial plexus structure;C-Peptide;C-reactive protein;Cesarean section;Child;Clinical;Continuous Glucose Monitor;Data;Deposition;design;Detection;Development;Diabetes Mellitus;Diagnosis;Disparity;Dystocia;early phase clinical trial;early pregnancy;Enrollment;Ensure;Environment;ethnic minority population;experience;Fasting;fetal;First Pregnancy Trimester;Fracture;Functional disorder;Future;Gestational Age;Gestational Diabetes;Glucose;glycation;Glycosylated hemoglobin A;Goals;Hawaii;Health;high risk;Hyperglycemia;Hypertriglyceridemia;improved;Individual;Infant;Inflammation;Injury;Insulin Resistance;interest;intrauterine environment;Laboratories;Late pregnancy;Lead;Life Style;machine learning model;Measurement;Measures;Metabolic;Metabolic dysfunction;metabolic profile;Methods;mortality;Mothers;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal Mortality;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;obesogenic;offspring;OGTT;Oral Administration;Oral Diagnosis;Organogenesis;Outcome;Outpatients;Participant;Perinatal;perinatal complications;perinatal outcomes;Phenotype;Placenta;Plasma;Postpartum Period;Pre-Eclampsia;Prediabetes syndrome;Pregnancy;pregnancy hypertension;Pregnant Women;prenatal exposure;Prevalence;primary outcome;Protocols documentation;Qualifying;racial minority population;Recommendation;recruit;Regimen;reproductive;Risk;Risk Factors;Sample Size;Sampling;screening;Shoulder;stillbirth;Symptoms;Technology;Testing;Third Pregnancy Trimester;Time;Triglycerides;Woman;women's diagnosis;Work

PROJECT_TITLE: ChartGlucose4Moms: Characterizing by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Establishing the CANOE Partnership as a resource within the infrastructure of the Consortium solidifies our previous efforts into an entity within an ecosystem of success regarding the fight against cancer mortality among our relatives. We anticipate that while this is a significant step toward Indigenous Cancer Health Equity, it remains a beginning to a long journey ahead and look forward to continuing these efforts in partnership with our Tribal and community collaborators, and with NIMHD as a strong partner in a long term relationship with a unified purpose: Achieving equitable outcomes for not only the cancers upon which the current projects focus; those with the highest cost in lives, but eventually across all cancer outcomes and across the entirety of Indian Country.

PI_NAMEs: MENDOZA, JASON A;NELSON, LONNIE A. (contact);PARKER, MYRA ELIZABETH

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Administrative Supplement;Adult;Aging;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;arm;Artificial Intelligence;Awareness;Behavior;Biometry;Black race;Breast Cancer Detection;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;cancer risk;Career Choice;career development;Catchment Area;chatbot;chest computed tomography;Child;Cities;Clinic;Clinical Trials Design;Collaborations;Colonoscopy;colorectal cancer screening;Communities;community based participatory research;community engagement;community partners;Comprehensive Cancer Center;cost;Country;Data;Death Rate;design;digital;Dimensions;Disparity;DNA;Ecosystem;empowerment;Ensure;Equity;Evaluation;experience;Faculty;fighting;Funding;Future;Future Generations;Goals;Grant;Health;Healthcare;HPV vaccine acceptance;Imaging technology;improved;Indigenous;Infrastructure;intergenerational;intertribal;Intervention;Island;lung cancer screening;Malignant Neoplasms;Mammography;Mentorship;Methodology;Methods;Modeling;modifiable behavior;mortality;mortality disparity;National Cancer Institute;National Institute on Minority Health and Health Disparities;Native-Born;next generation;Outcome;outreach;Pilot Projects;Policies;Population;prevent;Primary Prevention;Program Development;programs;Public Health;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;Resources;response;Rural;Sampling;screening;Screening for cancer;Screening procedure;Services;Sigmoidoscopy;Site;smoking cessation;Smoking Cessation Intervention;social determinants;Source;Special Population;success;Supervision;Testing;Tobacco smoking behavior;tribal community;Tribal group;tribal organization;Tribes;U-Series Cooperative Agreements;Universities;urban area;Vaccination;Washington;Work;Youth

PROJECT_TITLE: CANOE Partnership: Cancer Awareness, Navigation, Outreach, and Equitable Indigenous Health Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (A1)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: MENDOZA, JASON A (contact)

PROJECT_TERMS: Address;Artificial Intelligence;Awareness;Biometry;Breast Cancer Detection;Cancer health equity;cancer prevention;Catchment Area;Charge;Child;Collaborations;Collection;colorectal cancer screening;Common Data Element;Communities;community based participatory research;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Data;Data Analyses;Data Collection;design;Development;Dimensions;Diné Nation;empowerment;Ensure;Equity;Evaluation;experience;Geography;Goals;Health;holistic approach;Human Papilloma Virus Vaccination;Indigenous;Inequity;Infrastructure;Institution;Knowledge;Lead;Leadership;Learning;lung cancer screening;Malignant Neoplasms;Measures;Methods;Modeling;Native-Born;operation;Outcome;outreach;Participant;PhenX Toolkit;Process;programs;Research;Research Personnel;Research Project Grants;Resources;screening;Screening for cancer;smoking cessation;social health determinants;Structure;Students;success;Technology;tool;tribal community;tribal organization;Tribes;Universities;virtual education;Washington;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: PARKER, MYRA ELIZABETH (contact)

PROJECT_TERMS: Address;Advocacy;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Awareness;Cancer Burden;cancer care;cancer health disparity;Cancer health equity;cancer prevention;Caring;Catchment Area;Child;Colorectal Cancer;Communities;community based participatory research;community empowerment;community engaged approach;community engagement;community organizations;Community Outreach;community partnership;community research;Data;distrust;Education;Ensure;Equity;Ethnic Population;Event;experience;Female Breast Carcinoma;Food;Foundations;Goals;Grant;healing;Health;Healthcare;Hematologic Neoplasms;improved;Incidence;Indigenous;Individual;Inequity;innovation;Institution;Knowledge;Logic;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Mission;Modeling;mortality;National Institute on Minority Health and Health Disparities;Native-Born;Needs Assessment;novel strategies;Outcome;outreach;Policy Maker;programs;racial minority population;Research;Research Activity;Research Ethics;Research Personnel;Research Priority;resilience;screening disparities;Screening for cancer;service organization;System;systems research;Training;Translating;tribal community;tribal member;tribal Nation;tribal organization;Tribes;Universities;Washington;Work

PROJECT_TITLE: Community Engagement Core: Community Engagement will include Dialogue, Advocacy, and Research (CEDAR)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BRICKER, JONATHAN B (contact)

PROJECT_TERMS: 2 arm randomized control trial;Abstinence;Address;Adult;Advertisements;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Artificial Intelligence;Awareness;Behavior;Biochemical;cancer prevention;Cellular Phone;Cessation of life;chatbot;Cigarette;cigarette smoke;cigarette smoking;Communities;community organizations;Complex;coping;cost;Data;diaries;Dissemination and Implementation;efficacy evaluation;Emotional;Equity;Ethnic Origin;Ethnic Population;experience;FDA approved;Geography;Group Therapy;Health;health equity;health inequalities;Health Insurance;Healthcare Systems;Heart Diseases;Hospitals;improved;Income;Indian reservation;Indigenous;Individual;Industry;Inequity;Institutional Racism;Intervention;intervention program;Interview;large language model;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediation;Mediator;Medical;Modeling;Motivation;National Cancer Institute;Natural Language Processing;Northern Plains Tribe;Outcome;outcome disparities;outreach;Participant;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;Prevalence;programs;Provider;Race;racial population;Randomized;Randomized, Controlled Trials;recruit;Relapse;Research;Research Project Grants;Respiratory Disease;response;retention rate;Ritual compulsion;rural area;sex;skills training;smartphone application;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking-related cancer;social health determinants;Social support;System;Technology;Therapeutic;Time;Tobacco;tobacco control;Training;Trauma;trial comparing;tribal organization;Tribes;Trust;United States;urban Native American;user centered design;virtual education

PROJECT_TITLE: Research Project 1: Navigation and Artificial Intelligence Technology for Indigenous Virtual Education on smoking cessation (NAITIVE)


PI_NAMEs: TRIPLETTE, MATTHEW ADAM (contact)

PROJECT_TERMS: Age;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;arm;Awareness;Cancer Etiology;Cancer Prevention Intervention;Caring;Cessation of life;Chest;chest computed tomography;Cigarette;cigarette smoking;Clinical Trials;Communities;community academic partnership;community based participatory research;Community Healthcare;community partners;community setting;Comprehensive Cancer Center;Continuity of Patient Care;Data;Dimensions;Discrimination;Disparity;Dose;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation trial;Eligibility Determination;Enrollment;Epidemiology;Equity;ethnic minority;Ethnic Population;Evaluation;experience;Exploration, Preparation, Implementation, and Sustainment;Guidelines;Health;Health behavior;health care settings;health determinants;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;High Prevalence;implementation framework;improved;Incidence;Indigenous;interest;Intervention;Knowledge;lung cancer prevention;lung cancer screening;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;member;Methods;minority communities;Minority Groups;minority health;minority health disparity;mortality;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Outcome;outreach;patient navigation;patient navigator;patient population;Patients;personalized approach;Persons;Pilot Projects;Population;Population Decreases;Populations at Risk;pragmatic intervention;Primary Care;Process;racial minority;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Project Grants;Resources;Rural;screening;Services;Site;Smoking;smoking cessation;Smoking History;social determinants;social health determinants;therapy design;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;Tribal group;tribal healthcare;Tribes;Underserved Population;United States;United States National Institutes of Health;United States Preventative Services Task Force;uptake;urban area;urban dwelling;Washington

PROJECT_TITLE: Research Project 3: Strengthening Awareness and Community Resources for Early Detection of LUng cancer through Navigation Guided Screening (SACRED LUNGS)


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Precision Medicine;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) mortality is linked to modifiable health behaviors such as physical activity, alcohol intake, and diet; however, <10% of CRC survivors adhere to health behavior recommendations (HBR) after diagnosis. In non-cancer populations, personalized self-management training programs have been associated with increased adherence to HBR when compared to standardized interventions, but a personalized approach to lifestyle self-management has not yet been tested in a cancer population. This prospective, two-parallel-arm, randomized controlled trial will test whether a personalized self-management training intervention improves adherence to HBR among CRC patients when compared to a standardized health behavior education control.

PI_NAMEs: SLEIGHT, ALIX G. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Adherence;Aftercare;Alcohol consumption;American;anti-cancer research;Area;arm;Behavior;Behavior Therapy;behavioral clinical trial;Behavioral Sciences;Biometry;Cancer Center;cancer diagnosis;Cancer Survivor;career development;Clinical;clinically relevant;colon cancer patients;Colorectal Cancer;Complex;compliance behavior;Controlled Clinical Trials;design;Diabetes Mellitus;Diagnosis;Diet;Dose;Education;Educational Intervention;Educational process of instructing;Educational workshop;efficacy evaluation;Enrollment;Environment;Funding;Goals;group intervention;Habits;Health;health assessment;Health behavior;Health behavior change;healthy lifestyle;implementation science;improved;Incidence;Institution;Intervention;intervention delivery;Interview;Life;Life Style;lifestyle factors;Link;Malignant Neoplasms;Managed Care;Measurement;Measures;Mediating;Mediator;Mentors;modifiable lifestyle factors;mortality;novel strategies;Outcome;Participant;Patient-Focused Outcomes;Patients;personalized approach;Philosophy;Physical activity;Physical Function;Pilot Projects;Population;Precision Health;Procedures;Process;process evaluation;Program Development;programs;prospective;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Recurrence;reduce symptoms;Research;risk stratification;secondary outcome;Self Efficacy;Self Management;self-management program;skills;Spinal cord injury;Standardization;stem;Survival Rate;Symptom Burden;Testing;therapy design;tool;Training;Training Programs;treatment effect;Treatment Efficacy;Triage;United States;uptake;Work

PROJECT_TITLE: Risk-stratified self-management care for colorectal cancer survivors: a new approach to increasing adherence to health behavior recommendations

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Neurosciences;Opioids;Pain Research

ORG_CITY: Boston

ORG_NAME: PASCALL SYSTEMS, INCORPORATED

PHR: Project Narrative Post-surgical pain is a major contributor to chronic pain, opioid dependence, and opioid substance abuse. While anesthesiologists have many tools for treating surgical and post-operative pain, they have no tools to monitor how well their treatments might be working, making it difficult if not impossible to accurately and reliably treat nociception during surgery and minimize post-operative pain. In this project we will develop a promising novel technology to actively assess pain and analgesia during general and regional anesthesia.

PI_NAMEs: LE MAU, TUAN  (contact);PURDON, PATRICK L.

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Absence of pain sensation;Acute;Algorithmic Analysis;Analgesics;Anesthesia procedures;Anesthetics;Anti-Hypertensive Agents;base;Blood Pressure;chronic pain;Code;Conduction Anesthesia;Confidence Intervals;Conscious;Data;Devices;Dose;Electric Stimulation;Electrodes;Electroencephalography;Engineering;Event;Event-Related Potentials;General Anesthesia;Guidelines;Heart Rate;Hemorrhage;human data;Human Volunteers;improved;intense pain;Knowledge;Marketing;Measures;Methods;Monitor;new technology;Nociception;novel;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;Pain;Pain management;Pain Measurement;pain score;Patients;Persistent pain;Pharmaceutical Preparations;Phase;Postoperative Care;Postoperative Pain;Predisposition;Propofol;Regulatory Pathway;remifentanil;response;Scalp structure;Sedation procedure;sensor;Signal Transduction;Small Business Technology Transfer Research;software development;Stimulus;Substance abuse problem;System;Techniques;Technology;Time;tool;United States;usability;Work

PROJECT_TITLE: Developing Active Stimulation and Monitoring Technologies to Optimize Pain and Nociception Management During Regional Anesthesia, General Anesthesia, and Post-Operative Care


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Prevention;Prostate Cancer;Urologic Diseases;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL

PI_NAMEs: MCCORMICK, DAVID  (contact)

PROJECT_TERMS: Androgens;Animals;Biological Markers;Evaluation;Experimental Models;Genes;immunogenicity;Immunoprevention;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;men;preclinical development;preclinical efficacy;prevent;Preventive;programs;Prostate;prostate cancer model;Regimen;Risk;RNA vaccine;Target Populations;tumor;Vaccination;Vaccines

PROJECT_TITLE: PREVENT PROGRAM: PRECLINICAL EFFICACY AND INTERMEDIATE ENDPOINT BIOMARKERS; TASK ORDER TITLE: PRECLINICAL DEVELOPMENT OF AN RNA VACCINE FOR IMMUNOPREV


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: MC LEAN

ORG_NAME: BOOZ ALLEN HAMILTON

PI_NAMEs: FERNANDEZ, ANNA  (contact)

PROJECT_TERMS: Affect;Anxiety;Artificial Intelligence;Biopsy;Cancer Detection;cancer diagnosis;Chest;Clinical Data;clinical decision-making;cloud based;Communities;computer aided detection;Contractor;Data;data sharing;Database Management Systems;deep learning;Diagnosis;Diagnostic;Diagnostic Procedure;FDA approved;follow-up;Health Care Costs;Health Personnel;Healthcare;Image;improved;Internet;Link;low dose computed tomography;Lung;lung cancer screening;Lung CAT Scan;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Medical Imaging;mortality;Patients;Radiation;Research;Resources;risk prediction;Scanning;screening;Secure;Software Tools;Source;System;Testing;tool;Uncertainty;uptake

PROJECT_TITLE: LOW-DOSE COMPUTED TOMOGRAPHY IMAGES AND CORRESPONDING DATA


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PI_NAMEs: ZANOS, STAVROS  (contact)

PROJECT_TITLE: RECONSTRUCTING VAGAL ANATOMY


NIH_SPENDING_CATS: Cancer;Drug Abuse (NIDA only);Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WASHINGTON

ORG_STATE: DC

PI_NAMEs: KLEIN, AMANDA  (contact)

PROJECT_TERMS: Behavioral Research;Contractor;Division of Cancer Control and Population Sciences;editorial;Grant;Logistics;meetings;Persons;Preparation;programs;Services;symposium;Tobacco Control Research;tobacco regulatory science;virtual;Writing

PROJECT_TITLE: Tobacco Control Research Branch Scientific and Logistic Support Core Services


NIH_SPENDING_CATS: Cancer

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: SACHI, KAREN  (contact)

PROJECT_TERMS: Medicaid;Medicare;Services

PROJECT_TITLE: SEER-MEDICARE AND SEER-MEDICAID SCIENTIFIC AND TECHNICAL SUPPORT SERVICES


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PI_NAMEs: MYLER, PETER  (contact)

PROJECT_TERMS: 3-Dimensional;Basic Science;Biological;Biomedical Research;Communicable Diseases;coronavirus disease;Emerging Communicable Diseases;Molecular;National Institute of Allergy and Infectious Disease;Organism;pathogen;pathogenic virus;priority pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases: Coronavirus


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 3-Dimensional;Antimicrobial Resistance;bacterial resistance;Basic Science;Biological;Biomedical Research;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Emerging Communicable Diseases;Molecular;National Institute of Allergy and Infectious Disease;Organism;pathogen;priority pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases for Anti-Microbial Resistant Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 3-Dimensional;Advanced Development;Basic Science;Biological;Biomedical Research;Communicable Diseases;Development;Influenza;Molecular;pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure;universal influenza vaccine

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza


PROJECT_TERMS: 3-Dimensional;Basic Science;Biological;Biomedical Research;Communicable Diseases;Emerging Communicable Diseases;Molecular;National Institute of Allergy and Infectious Disease;Organism;pathogen;priority pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Basic Science;Biological;Biomedical Research;Communicable Diseases;Emerging Communicable Diseases;Molecular;National Institute of Allergy and Infectious Disease;Organism;pathogen;priority pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases: SARS-CoV-2


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PI_NAMEs: SATCHELL, KARLA  (contact)

PROJECT_TERMS: 3-Dimensional;Advanced Development;Basic Science;Biological;Biomedical Research;Communicable Diseases;Influenza;Molecular;pathogen;programs;Proteins;Research;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure;universal influenza vaccine;Vaccine Research


PROJECT_TERMS: 3-Dimensional;Antimicrobial Resistance;Bacterial Drug Resistance;bacterial resistance;Basic Science;Biological;Biomedical Research;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Emerging Communicable Diseases;fungus;Molecular;National Institute of Allergy and Infectious Disease;Organism;pathogen;priority pathogen;programs;Proteins;Research;Research Activity;Research Project Grants;Research Support;Role;structural biology;Structure;Technology;three dimensional structure

PROJECT_TITLE: Centers for Research on Structural Biology of Infectious Diseases: Antibacterial Resistance Research Activities


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: BOGGS, ABBEY  (contact)

PROJECT_TITLE: SUPPORT FOR THE SEER-CAHPS INITIATIVE


ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: WISE, JAMES  (contact)

PROJECT_TERMS: Cancer Trials Support Unit;Clinical;Clinical Trials;Collection;Computer software;Contractor;Data;Databases;Decision Analysis;Development;electronic patient reported outcomes;Health;health data;Human;Human Resources;Libraries;Licensing;Life Cycle Stages;Methodology;migration;Modeling;National Cancer Institute;Patient Outcomes Assessments;Patients;Performance;Phase;Process;programs;Questionnaires;Recommendation;Resources;Services;System;Training;Update

PROJECT_TITLE: CANCER TRIALS SUPPORT UNIT IDIQ: TASK ORDER 6A: ELECTRONIC PATIENT-REPORTED OUTCOMES (PROS)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Veterans with bipolar disorder (BP) and comorbid substance use disorders (SUDs) have poor treatment adherence and poor clinical outcomes, high rates of suicide, and increased psychiatric hospitalization. They are at particularly high risk for treatment nonadherence when transitioning from psychiatric hospitalization to outpatient care, with little to no treatment options available to improve care of this high-risk population at the critical period following hospital discharge. The current project will test the effectiveness of Integrated Treatment Adherence Program (ITAP), which is the first adjunctive psychosocial program specifically designed to improve treatment adherence and reduce suicidality, bipolar symptoms, and substance use among high-risk patients with BP-SUD. If shown effective, ITAP could be easily and efficiently adopted as standard care for hospitalized Veterans with co-occurring BP and SUD within VHA. Findings from this study will inform clinical and policy efforts on the implementation of BP treatment for Veterans with co-occurring SUD post-discharge.

PI_NAMEs: GAUDIANO, BRANDON A;METRIK, JANE  (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Aftercare;Alcohol consumption;Alcohols;Ambulatory Care;Appointment;Area;Behavior;Behavioral;Bipolar Disorder;Blinded;Caring;Cessation of life;Clinical;comorbidity;contextual factors;critical period;Data;Death Rate;depressive symptoms;design;Disease;Dissemination and Implementation;Dose;Drug usage;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Electronics;Emergency department visit;Evaluation;evidence base;Feeling suicidal;follow-up;formative assessment;Future;future implementation;Gender;Health Care Costs;Health Services;high risk;high risk population;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation efforts;implementation framework;Implementation readiness;implementation strategy;implementation trial;improved;innovation;inpatient psychiatric treatment;inpatient service;Intervention;intervention effect;intervention program;Leadership;Manic;Measures;Mediating;Mediator;medication compliance;Mental Health;Methodology;Monitor;mood symptom;Moods;Opioid;opioid overdose;organizational readiness;Outcome;Participant;Patient Discharge;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;Population;Populations at Risk;Prevalence;preventive intervention;primary outcome;Problem Solving;process evaluation;programs;psychiatric inpatient;psychosocial;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reducing suicide;Relapse;Research;Research Priority;safety assessment;Sampling;scale up;secondary outcome;Severities;Site;skills;Social Workers;standard care;standard of care;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Telephone;Testing;Therapeutic;therapy design;Training;treatment adherence;treatment as usual;treatment effect;Treatment outcome;treatment risk;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Post-Hospital Intervention for Veterans with Comorbid Bipolar and Substance Use Disorders

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Chemotherapy-induced neuropathic pain is a debilitating side effect of many chemotherapeutics. The neuropathies are the principle reason why many patients stop potential curative therapy, impacting their survival. This project will validate novel mechanism-based molecular targets for the prevention and treatment of chemotherapy-induced neuropathic pain which might hasten the development of novel therapeutics.

PI_NAMEs: MELEMEDJIAN, OHANNES KEVORK (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Adopted;aerobic glycolysis;Affect;Afferent Neurons;Animals;anti-cancer;Antineoplastic Agents;Behavioral;Biochemical;Biological Assay;Bortezomib;Cancer Survivor;cancer therapy;chemotherapy;curative treatments;Data;Development;Dose;Enzyme Inhibition;Enzymes;experimental study;extracellular;Fluorescence Microscopy;Gene Silencing;Genetic Transcription;Glycolysis;Growth;Histologic;Hypoxia Inducible Factor;imaging modality;innovation;Knockout Mice;lactate dehydrogenase A;Lewis Lung Carcinoma;Life;Maintenance;Malignant Neoplasms;Measurement;Measures;Mediator;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Molecular Target;mouse model;Mus;Neuropathy;new therapeutic target;novel;novel therapeutics;oxaliplatin;Oxidative Phosphorylation;Paclitaxel;Pain;painful neuropathy;Patients;PDH kinase;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phase;Platinum;prevent;Prevention;Production;Productivity;Proteasome Inhibitor;Quality of life;Rehabilitation therapy;Risk;Role;side effect;taxane;Therapeutic;Toxic effect;transcription factor;Translations;treatment effect;tumor;tumor growth;Tumor Volume;Validation

PROJECT_TITLE: Identification of novel targets for the treatment of chemotherapy-induced painful peripheral neuropathy


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE Mutations in genes GUCY2D and GUCA1A cause retinal degeneration by deregulating cGMP production in photoreceptors. We propose to explore versatile molecular mechanisms capable of averting the adverse biochemical process causing death of photoreceptors and thus rescue them. This knowledge can become useful in developing treatment for the presently incurable GUCY2D and GUCA1A dominant retinopathies.

PI_NAMEs: DIZHOOR, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Address;Alleles;Animal Model;autosomal dominant mutation;Binding;Biochemical;Biochemical Pathway;Biochemical Process;Blindness;Cause of Death;Cessation of life;cGMP production;Code;Complex;cone-rod dystrophy;Cyclic GMP;Darkness;design;Development;Disease;Ectopic Expression;Engineering;Eye diseases;Foundations;Future;gain of function;gain of function mutation;gene therapy;Genes;Genetic Models;guanylate;Guanylate Cyclase;guanylate cyclase activating protein;Human;Hydrolysis;inhibitor;Isoenzymes;Knowledge;Light;Link;Mission;Molecular;mouse development;mouse model;Mus;mutant;Mutation;novel strategies;overexpression;phosphodiesterase V;phosphoric diester hydrolase;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiological;Physiology;Point Mutation;preservation;prevent;Production;prospective;Protein Engineering;protein expression;Protein Isoforms;Proteins;public health relevance;Recombinants;Reporting;Research;Research Support;Retina;Retinal Degeneration;Retinal Diseases;RNA Interference;Rod;Rod Outer Segments;stem;Study models;targeted treatment;Testing;tool;transgene expression;Transgenic Animals;Transgenic Mice;Transgenic Model;Variant;Vertebrate Photoreceptors;Vision;Vision Disorders

PROJECT_TITLE: Mechanisms to Rescue Photoreceptors in GUCY2D and GUCA1A Retinopathies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AR

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Invasive melanoma is a potentially deadly medical condition, with an incidence of 100,000 new cases in 2021 alone. Melanoma research has mainly focused on melanocyte dysregulation to understand the disease; yet, the epidermis is an important microenvironment for healthy melanocytes, which adhere to and communicate with keratinocytes to maintain homeostasis. In this project, we will test hypothesis that melanocytes and epidermal cells form specialized adhesions important for melanocyte migration and retention within the epidermis, thereby contributing to the suppression of melanoma metastasis.

PI_NAMEs: RICHARDS, DENAY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Acceleration;Actins;Adherens Junction;Adhesions;Adhesives;assault;Basement membrane;Basic Science;Behavior;Belief;Biological;Cadherins;cell motility;cell type;Cells;Cellular biology;cellular imaging;Cessation of life;Clinical;Collaborations;Color;Communication;Complex;confocal imaging;Cre lox recombination system;Data;Defect;design;Development;Diagnosis;Disease;E-Cadherin;Embryo;Environment;Epidermis;Epithelial Cells;Epithelium;Esthetics;Excision;Fibroblasts;Future;Genetic;Genetic Transcription;Goals;Hair follicle structure;holistic approach;Homeostasis;Hospital Departments;Human;Image;Immune;Immunoglobulin Class Switching;Impairment;Incidence;Individual;intercellular communication;Intercellular Junctions;Intervention;Invaded;Keloid;keratinocyte;Knock-out;Knowledge;Label;Life;Mechanics;Medical;melanoblast;melanocyte;Melanoma;Melanoma Cell;Membrane;Mentorship;Metastatic Melanoma;migration;Molecular;Morphology;mortality;mouse model;Mus;N-Cadherin;Neoplasm Metastasis;novel strategies;Operative Surgical Procedures;Patients;Pigments;Plastic Surgeon;Plastic Surgical Procedures;Precancerous Melanosis;prevent;Proliferating;promoter;reconstruction;Recording of previous events;Reporter;Research;Resolution;Resources;Role;single-cell RNA sequencing;Skin;skin barrier;Skin Cancer;superresolution imaging;superresolution microscopy;Surgeon;Survival Rate;Testing;Therapeutic Research;Training;transcriptomics;Translational Research;tumor;Tumor Suppression;ultra high resolution;United States;Universities;University Hospitals;Up-Regulation;Visualization;Vitiligo;Wood material;Work

PROJECT_TITLE: Investigating the epidermal microenvironment in melanoblast migration and invasion: a novel approach to understanding invasive melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The overarching research theme for the Mount Sinai U54 is to understand factors that may compromise the immune response of lung cancer patients following SARS-CoV-2 infection or vaccination in comparison to a matched “healthy” control group. Comprehensive serologic and cellular analyses of serially collected blood samples from consented patients coupled to a highly annotated database of patient clinical and demographic factors will be used to identify vulnerabilities inherent to this patient population, augmented by in vitro modeling.

PI_NAMEs: GARCIA-SASTRE, ADOLFO ;HIRSCH, FRED R (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Antibody Response;Area;Biological Assay;Biological Factors;Blood specimen;Cancer Patient;cancer therapy;Clinical;Consent;Control Groups;Coupled;COVID-19 susceptibility;Databases;Demographic Factors;Enzyme-Linked Immunosorbent Assay;experience;Immune response;in vitro Model;Infection;Influenza vaccination;influenzavirus;long term consequences of COVID-19;Longitudinal cohort;Lung immune response;Malignant neoplasm of lung;Molecular;Mucosal Immune Responses;novel;patient population;Patient Selection;Patients;Plasma;post SARS-CoV-2 infection;Research;Residual state;Risk;sample collection;SARS-CoV-2 infection;Serology;socioeconomics;Specimen;Symptoms;Update;Vaccination;vaccine platform;Vaccines;Variant;Viral Proteins;Viral reservoir;viral RNA;Virus Diseases

PROJECT_TITLE: Vulnerability of SARS- CoV-2 Infection in Lung Cancer Based on Serological Antibody Analyses


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

PHR: PROJECT NARRATIVE We propose to utilize the Youth Risk Behavior Survey (YRBS) to assess alcohol use disparities between sexual minority youth (SMY) and heterosexual youth at the intersections of multiple marginalized identities including sex and race/ethnicity, and to determine how these associations impact HIV vulnerability. The team’s pooled dataset, which contains 950,295 youth from local versions of the YRBS, will be extended to include YRBS data collected between 2021 and 2025, providing the opportunity to conduct innovative, intersectional research on the associations between alcohol use, HIV vulnerabilities, and mental health on a national scale and adapt novel methodologies for this purpose. This project builds upon a highly successful prior R01 which facilitated critical health disparities research, interdisciplinary collaboration, and high-impact publication, by strengthening the available sample and leveraging additional modes of complex quantitative inquiry to support innovation in analysis and application of results.

PI_NAMEs: PHILLIPS, GREGORY L. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adolescence;Adolescent Risk Behavior;Adult;Age;aging population;Alaska Native;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol risk;Alcohols;American;American Indians;Anxiety;Area;Attenuated;Behavior;behavioral and social science;binge drinking;Bisexual;Categories;Cities;Climate;college;comparative;Complex;County;Critical Pathways;Data;Data Pooling;Data Set;Dependence;Development;Disparity;drug of abuse;Drug usage;Emergency department visit;Ensure;Epidemiology;ethnic minority;Ethnic Origin;experience;Funding;Goals;Health;Health behavior;Health Disparities Research;health disparity;health equity;Heterosexuals;high school;High School Student;HIV;HIV disparities;HIV risk;Individual;individual variation;innovation;interdisciplinary collaboration;Intervention;Investigation;Journals;large datasets;Legal;lens;male;marginalization;Mental Depression;Mental Health;Methodology;Methods;Minority Status;minority stress;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;Neurocognitive;NIH Office of AIDS Research;non-suicidal self injury;novel;Outcome;outcome disparities;Participant;Pathway interactions;Pattern;Pediatrics;peer;Peer Review;physical conditioning;Policies;Population;Positioning Attribute;Prevalence;psychological distress;Public Health;Publications;Race;racial minority;Reporting;Research;Research Personnel;Research Priority;risk minimization;Role;same-sex marriage;Sample Size;Sampling;School-Age Population;Schools;sex;Sex Behavior;Sex Orientation;Sexual Health;sexual identity;sexual minority;sexual minority youth;Social Change;social science research;social stigma;Statistical Methods;Stigmatization;substance use;success;Suicide;Surveys;Techniques;theories;Time;Time trend;Tobacco use;trend;United States;Unsafe Sex;Vulnerable Populations;Work;young men who have sex with men;Youth

PROJECT_TITLE: Intersectional Approaches to Population-Level Health Research: Role of HIV Risk and Mental Health in Alcohol Use Disparities among Diverse Sexual Minority Youth


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAN DIEGO

ORG_NAME: CALIFORNIA MEDICAL INNOVATIONS INSTITUTE

PHR: Curation of biomedical research data is essential for promoting rapid discovery and innovation. The goal of this project is to continue the development of SODA, the desktop software designed to assist SPARC researchers in curating their data easily through an interactive interface and integrated automation.

PI_NAMEs: PATEL, BHAVESH  (contact)

PROGRAM_OFFICER_NAME: QASHU, FELICIA M

PROJECT_TERMS: Acceleration;Address;Automation;Biomedical Research;Code;Complex;Computer Assisted;Computer software;Consumption;Data;Data Analyses;Data Collection;data curation;Data Set;data sharing;data standards;Development;Devices;digital data;FAIR principles;Funding;Goals;Guidelines;human error;improved;innovation;Investments;Knowledge;Metadata;Mission;Nerve;Organ;Phase;Process;Research Personnel;Science;Software Design;software development;therapeutic development;Time;Update;Walking;Work

PROJECT_TITLE: SODA - Desktop Software to Enhance the SPARC Data Curation Workflow


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Latino adults in the United States (U.S.) are 1.5 times more likely to develop Alzheimer’s disease and related dementias (ADRD) compared to non-Hispanic White adults and although treatment of obstructive sleep apnea (OSA) reduces OSA symptoms, improves cognition and quality of life, no existing studies have focused on improving treatment adherence to positive airway pressure (PAP) in this population. This project proposes to develop and test Nuestro Sueño, the first, culturally-adapted PAP adherence and sleep health intervention for Latino couples. The results of this study could significantly reduce the burden of OSA for patients and their partners, and may identify a novel target of preventing ADRD among Latinos, who remain under-represented in both ADRD and sleep disorders research.

PI_NAMEs: ALCANTARA, CARMELA ;BARON, KELLY GLAZER (contact);TROXEL, WENDY M

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acculturation;actigraphy;Address;Adherence;Adult;Affect;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Arizona;Beds;behavioral health intervention;Belief;Cardiometabolic Disease;cardiometabolic risk;Cognition;Cognition Disorders;Cognitive aging;cognitive function;cognitive performance;Cognitive Therapy;Collaborations;Communication;community advisory board;Community Health Aides;compliance behavior;coping;Couples;cultural values;culturally appropriate intervention;Data;Dedications;dementia risk;Development;Diagnostic;diaries;Disease;Disparity;disparity reduction;Ethnic Population;evidence base;Evidence based intervention;experience;Family;feasibility testing;field study;flexibility;Focus Groups;follow-up;Future;Goals;Health;health disparity;healthy aging;high risk;Impaired cognition;improved;Individual;innovation;Intervention;Language;Latino;Latino Population;Link;Measures;Medical;Metaphor;Modeling;Morbidity - disease rate;mortality;National origin;neglect;Not Hispanic or Latino;novel;Obstructive Sleep Apnea;Outcome;Patient Noncompliance;Patients;Phase;Population;positive airway pressure;prevent;Prevention;Process;Public Health;Quality of life;racial disparity;racial population;randomized, clinical trials;Randomized, Controlled Trials;Research;response;Risk;Risk Reduction;Role;Sampling;satisfaction;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep health;Sleeplessness;social culture;sociocultural determinant;socioeconomic disparity;Socioeconomic Status;Solid;Spanish;Symptoms;System;telehealth;Testing;therapy development;Translations;treatment adherence;treatment arm;treatment disparity;treatment response;United States;United States National Institutes of Health;Utah

PROJECT_TITLE: Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Emergency Care;Health Services;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE In direct response to RFA-AG-22-024, we propose stage IA research (R61 phase) to adapt the Detection of Elder abuse Through Emergency Care Technicians (DETECT) screening tool for home-based primary care — with special emphasis on older adults who were recently diagnosed with AD/ADRD — The DETECT Revision for Primary Care (DETECT-RPC). We also propose a stage III multisite randomized (at the provider level) controlled efficacy trial (R33 phase) of DETECT-RPC.

PI_NAMEs: CANNELL, MICHAEL BRADLEY (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: abuse neglect;Accident and Emergency department;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;American Medical Association;authority;Caregivers;Cognitive;Communities;Complex;Computer software;design;Detection;Development;Diagnosis;Disease;Early Diagnosis;Early identification;efficacy trial;Elder Abuse;Eligibility Determination;Emergency Care;Emergency department screening;Emergency department visit;Emotional;emotional abuse;Environment;Ethics;evidence base;expectation;experience;Exposure to;Failure;Family member;financial exploitation;Focus Groups;Healthcare;Home;Hospitalization;improved;Injury;innovation;Interview;Laws;Link;Medical;Methods;mHealth;Morbidity - disease rate;mortality;neglect;older adult;Patients;peer;Persons;Phase;physical abuse;Physical environment;Physicians;Policies;Positioning Attribute;practice setting;Prevalence;Primary Care;primary care clinician;Primary Care Physician;primary care setting;Procedures;Property;Provider;provider-level barriers;Psyche structure;psychological distress;Quality of life;Randomized;Reporting;Research;response;Risk;Risk Factors;screening;Screening procedure;Security;Services;Sexual abuse;Site;Social Environment;Structure;Testing;Texas;tool;Trust

PROJECT_TITLE: Detection of Elder mistreatment Through Emergency Care Technicians - Revised for Primary Care (DETECT-RPC)


PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Feasibility of Using a Culturally Tailored Conversational Agent for promoting smoking cessation treatment utilization in African Americans who use cigarettes


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE For decades, pregnant individuals who identify as Black have been considered at greatest risk for hypertensive disorders of pregnancy (HDP), cardiovascular complications, and maternal mortality; as such, the social construct of race carries arguably the heaviest weight for Black pregnant individuals, whose current state has been described as a public health crisis in the United States. The proposed research provides many experimental opportunities to greatly impact multiple fields of research including: allostatic load, HDP, post- pregnancy cardiovascular health, and racial disparities among each. The findings will inform the development of evidence-based interventions that will focus on narrowing racial health disparities and improving pregnancy outcomes and cardiovascular health in females.

PI_NAMEs: RAY, MITALI  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Acceleration;adverse pregnancy outcome;Affect;allostatic load;American;Area;Bioinformatics;Biological;Biological Markers;Black Populations;Black race;black women;Cardiac health;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career development;Chronic;Chronic stress;Clinical;cohort;Competence;Complex;Data;data cleaning;data quality;Death Rate;Development;Disease;disease disparity;Disparity;DNA;DNA Methylation;early pregnancy;Eclampsia;epigenomics;Evidence based intervention;experience;Faculty;Female;First Pregnancy Trimester;Functional disorder;Funding;Future;Genes;Genetic Polymorphism;Genetic Variation;genome wide association study;Genomics;Genotype;Health Disparities Research;health disparity;Hypertension;improved;indexing;Individual;Inflammatory;innovation;insight;Institution;Institutionalization;Investigation;life span;Link;Maternal Mortality;Measures;meetings;Mentors;Mentorship;Metabolic;Methylation;Monitor;mortality;Mothers;multi-ethnic;novel;Nulliparity;Outcome Study;Parents;Participant;Pathway interactions;Phase;Physiological;Physiology;Positioning Attribute;post pregnancy;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;pregnant;Prevalence;Public Health;Quality Control;Race;racial disparity;racial health disparity;racism;Reduce health disparities;Research;Research Personnel;Risk;Risk Factors;Sampling;Secure;social;social health determinants;social structure;Stress;symposium;System;tenure track;Training;training opportunity;Translating;Trauma;United States;Weight;White Women

PROJECT_TITLE: Allostatic Load and Race: Implications for Cardiovascular Health in Pregnancy and Beyond

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ORG_CITY: PETERSBURG

ORG_NAME: VIRGINIA STATE UNIVERSITY

ORG_STATE: VA

PI_NAMEs: SIDDIQUI, RAFAT ALI (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TITLE: Pilot Project 1


PI_NAMEs: FAISON, MILTON O (contact)

PROJECT_TITLE: SUCCEED Pilot Project 2


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: AUCKLAND

ORG_COUNTRY: NEW ZEALAND

ORG_FIPS: NZ

ORG_NAME: UNIVERSITY OF AUCKLAND

PI_NAMEs: HUNTER, PETER JOHN (contact);NICKERSON, DAVID PHILLIP

PROJECT_TERMS: Anatomy;Autonomic nervous system;Biological;Biophysics;Body System;Communities;Data;data visualization;Databases;Ensure;Funding;improved;Internet;Maps;mathematical model;Medical;Medical Device;Modeling;models and simulation;multi-scale modeling;multiple data types;Nerve;neural model;Organ;Peripheral;Physiological;Physiology;programs;Reproducibility;Resources;Role;Science;simulation;tool;United States National Institutes of Health;Visceral;Visualization software

PROJECT_TITLE: Multi-scale, multi-organ, multi-species SPARC map management

STUDY_SECTION: DCMM

STUDY_SECTION_NAME: Data Coordination, Mapping, and Modeling[DCMM(50)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative In sub-Saharan Africa, where Kaposi’s sarcoma-associated herpesvirus (KSHV) seroprevalence and HIV incidence are highest in the world, the effects of the oral environment on oral KSHV reactivation and shedding in people living with HIV (PLWH) before Kaposi’s sarcoma (KS) development are unknown. We propose the first and largest longitudinal study to our knowledge that will assess the effects of oral health, oral environment, and the oral microbiome on KSHV reactivation and shedding in rural Ugandan adults living with and without HIV infection. We will leverage an experienced multi-disciplinary team, a strong study design, and innovative and validated research techniques to identify the effects of the oral environment on KSHV reactivation in PLWH, a profound knowledge gap integral to identifying pre-risk measures for oral cavity KS involvement and developing prevention tactics in the region most affected.

PI_NAMEs: SABOURIN, KATHERINE R (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Affect;Africa South of the Sahara;antiretroviral therapy;Area;Automobile Driving;Award;Caring;catalyst;Clinic;cohort;Data;Development;dysbiosis;Enrollment;Environment;Etiology;Exhibits;experience;Female;Foundations;General Population;Gingivitis;Healthcare;high risk population;HIV;HIV Infections;Human Herpesvirus 8;Immune;Immune response;Immunoglobulin A;Incidence;inflammatory marker;innovation;Intervention;Kaposi Sarcoma;Knowledge;Liquid substance;Longitudinal Studies;male;Malignant Neoplasms;Measures;mortality;Mouth Diseases;Mucositis;multidisciplinary;Newly Diagnosed;Oral;Oral cavity;Oral health;oral lesion;oral microbiome;Oral mucous membrane structure;Palate Kaposi's Sarcoma;Participant;Pathogenesis;Patients;Periodontitis;Persons;Prevention;Research;Research Design;Research Technics;Resolution;Ribosomal RNA;Risk;Role;Rural;Rural Population;Saliva;Seroprevalences;Techniques;Testing;Therapeutic;Uganda;Viral Load result

PROJECT_TITLE: Effects of the oral environment on KSHV shedding in Ugandan adults living with HIV


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Clinical Research;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Experiences of stress and trauma across the life course may result in poor cardiometabolic outcomes during pregnancy, postpartum, and later life. This project aims to use data on stress and trauma across the life course to examine the impact of cumulative stress on cardiometabolic function during pregnancy and following childbearing and cardiometabolic risk behaviors postpartum. The results of this project will inform theory, potential intervention development, and the understanding of the impact of stress and trauma on health.

PI_NAMEs: STANHOPE, KAITLYN K (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Adult;adverse pregnancy outcome;Behavior;biological adaptation to stress;Biological Markers;Black race;Blood;Blood Pressure;Body mass index;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;child bearing;Childhood;Clinic;Clinical;cohort;Communities;Conceptions;Data;Data Collection;data registry;Data Set;depressive symptoms;Development;Diagnosis;diet and exercise;Discipline of obstetrics;Disparity population;Environment;Epidemiology;experience;Exposure to;Face;Family;fasting glucose;follow-up;Functional disorder;Gestational Diabetes;Goals;Health;Health Services Accessibility;high risk;Hypertension;Income;Individual;infant outcome;Lactation;late life;Life Cycle Stages;Life Stress;Lipids;long-term sequelae;Longitudinal Studies;Low income;maternal morbidity;Maternal Mortality;maternal risk;Measurement;Measures;Mediation;Medical;Medical Records;Mentors;Mentorship;Metabolic;middle age;Modeling;Modification;multi-ethnic;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Participant;Pattern;Perinatal;Persons;Phase;placental morphology;post pregnancy;Post-Traumatic Stress Disorders;postpartum outcome;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Histories;pregnant;Pregnant Women;prenatal;prevent;Prevention strategy;prospective;Prospective, cohort study;psychosocial wellbeing;Questionnaires;racial disparity;racial minority;racism;rate of change;Recording of previous events;recruit;Registries;Research;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Secondary Prevention;Sleep;sleep quality;social health determinants;Social support;socioeconomic disparity;Stress;stressor;structural determinants;Surveys;Symptoms;theories;therapy development;Time;Training;Trauma;United States;Urine;Woman

PROJECT_TITLE: Accumulation of stress and trauma across the life course and cardiometabolic risk during pregnancy and postpartum

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This mixed methods study will use a large multi-site linked nurse and patient sample and econometric techniques for causal inference, to examine how nurse specialty certifications may impact individual nurse performance and patient outcomes and costs. The study will provide robust, causal, and reliable evidence to inform organizational investments in nurse human capital to optimize nurse performance, achieve targeted patient outcomes, and reduce costs of care, thus directly responding to AHRQ’s priority to increase the affordability and efficiency of care.

PI_NAMEs: COSTA, DEENA KELLY;YAKUSHEVA, OLGA  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: The impact of specialty nursing certification on patient outcomes and costs in acute care: An individual value-added performance analysis

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: OVERALL COMPONENT: PROJECT NARRATIVE ICON will expand authentic tribal-cancer center capacity to improve cancer outcomes for American Indian and Alaska Native (AI/AN) persons through a coordinated program of research projects addressing three major cancer research priorities identified by our AI/AN stakeholders - prevention, screening and cancer care coordination. Career enhancement activities for ICON investigators will be integrated into the research projects and curricula will focus on the conduct of research in the context of tribal sovereignty. All of this will be accomplished through ICON’s unmatched approaches to community engagement with Tribal Nations.

PI_NAMEs: DOESCHER, MARK P;RHOADES, DOROTHY ALISON (contact);SPICER, PAUL G

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Address;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Area;Arsenic;Attention;cancer care;Cancer Center;Cancer health equity;Cancer Patient;cancer prevention;care coordination;career;Cherokee Nation;Choctaw Nation of Oklahoma;Chronic;Clinical Trials;Collaborations;collaborative care;Communication Programs;Communities;community engagement;Community Health;community partners;Consultations;Death Rate;design;drinking water;Economics;Education;Educational Curriculum;Elements;Ensure;Environment;Equity;Evaluation;Excision;Exhibits;experience;Exposure to;Extramural Activities;federal policy;Fostering;Foundations;Funding;General Population;Grant;Health;health care availability;Health Status;Health system;Home;Household;improved;Incidence;Indigenous;Infrastructure;Intervention;Leadership;Location;lung cancer screening;Malignant Neoplasms;Medical Care Team;member;Mentorship;Monitor;mortality;Native American community;Native Americans;Needs Assessment;novel;Oklahoma;Oncology;Outcome;Outcomes Research;Patients;Perception;Performance;Persons;Population;Prevention;Prevention Research;Program Research Project Grants;programs;recruit;Research;Research Personnel;Research Priority;Research Project Grants;research study;Reservations;resilience;Rights;Rural;rural area;screening;screening program;Structural Racism;System;telehealth;Testing;therapy development;Translating;tribal community;tribal health;tribal Nation;tribal organization;Tribally Based Participatory Research;Tribes;Trust;United States;United States Indian Health Service;Uranium;urban area;urban Native American;Water;Work;World War II

PROJECT_TITLE: Improving Cancer Outcomes In Native American Communities (ICON)


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: RHOADES, DOROTHY ALISON (contact)

PROJECT_TERMS: acceptability and feasibility;Advisory Committees;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Cancer Center;cancer education;Cancer health equity;career;Career Mobility;Cherokee Indian;Chickasaw Nation;Clinic;Collaborations;Common Data Element;Communication;Communities;community advisory board;community collaboration;community engagement;community engagement process;Community Outreach;cultural health;Data;Data Collection;data sharing;Decision Making;Development;distrust;Education;Educational process of instructing;Educational workshop;Ensure;Epidemiologist;Ethics;Evaluation;experience;Fostering;Foundations;Funding;Goals;Grant;Health;Healthcare Systems;improved;improved outcome;Indigenous;Infrastructure;Institution;Institutional Review Boards;interest;Kiowa;Lead;Leadership;Logic;Malignant Neoplasms;Maternal health equity;Measures;Mentors;Modeling;Monitor;National Institute on Minority Health and Health Disparities;Native American community;Native Americans;NCI Center for Cancer Research;Oklahoma;Outcome;Performance;PhenX Toolkit;Procedures;Program Evaluation;programs;Recurrence;Research;Research Personnel;Research Project Grants;research study;resilience;Rights;Secure;shared decision making;Structure;Students;success;Testing;Training;tribal community;tribal Nation;tribal organization;Tribally Based Participatory Research;Tribes;Trust;Underrepresented Populations;United States;United States Indian Health Service;United States National Institutes of Health;Universities;urban Native American

PROJECT_TITLE: Improving Cancer Outcomes in Native American Communities (ICON) - Administrative Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: SPICER, PAUL G (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Alaska Native;American;American Indians;anti-cancer research;Articulation;cancer care;Cancer Center;Cancer health equity;Cancer Model;cancer prevention;cancer therapy;care coordination;centralized portal;Clinical Sciences;Collaborations;Communication;Communities;community center;Community Developments;community engaged approach;community engaged research;community engagement;Community Outreach;Community Participation;community partners;design;Development;Ensure;Ethics;European;Evaluation;experience;Feedback;Foundations;Funding;Genomics;Goals;Health;health equity;Health system;Healthcare;improved;Indigenous;Indigenous American;innovation;Institution;Investments;Knowledge;Leadership;Learning;Letters;Lived experience;Malignant Neoplasms;member;Modeling;National Human Genome Research Institute;Native American community;Native Americans;Needs Assessment;Oklahoma;Outcome;outreach;Pathway interactions;Patients;Positioning Attribute;Prevention;Procedures;Protocols documentation;Public Health;Research;research and development;research data dissemination;Research Design;Research Personnel;Research Support;Resources;scaffold;screening;Series;success;Surveys;Techniques;Time;tool;Translating;Translational Research;Translations;tribal community;Tribal group;tribal Nation;Tribes;Trust;Universities;Work

PROJECT_TITLE: Improving Cancer Outcomes in Native American Communities (ICON) - Community Engagement Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Cancer;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Urologic Diseases

PI_NAMEs: NIGRA, ANNE E (contact)

PROJECT_TERMS: Adult;Alaska Native;Alaska Native population;American Indian Population;American Indians;Arsenic;Automobile Driving;Bladder;Cancer Etiology;cancer prevention;carcinogenicity;cardiovascular health;cohort;Collaborations;Communities;community engagement;Community Health;dashboard;Data;Data Set;Disparity;drinking water;Educational workshop;Engineering;epidemiologic data;Epidemiology;epidemiology study;Ethics;Evaluation;experience;exposure reduction interventions;Exposure to;Family Study;follow-up;Goals;Great Plains;ground water;Health;Health behavior;health disparity;Health Personnel;Heart;Household;Human;improved;improved outcome;Incidence;Indigenous;Individual;informant;Intervention;Interview;Kidney;Knowledge;Link;Lung;Mainstreaming;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Medical Records;member;Methods;Modeling;Monitor;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;Native American community;neoplasm registry;Northern Plains;novel;Outcome;Pancreas;Participant;Perception;Phase;Population;population based;predictive modeling;Prevention strategy;Primary Cancer Prevention;Privatization;Process;Prostate;public drinking;Recording of previous events;Records;Regulation;Renal Carcinoma;Research;Resources;Risk Assessment;Sampling;Science;Secondary Cancer Prevention;Site;Skin Cancer;social;successful intervention;System;therapy development;treatment trial;tribal community;tribal health;tribal organization;Tribes;United States Environmental Protection Agency;United States Indian Health Service;Update;Uranium;Urine;Water;Work

PROJECT_TITLE: Water for Health: Strengthening Tribal Action for Cancer Prevention


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: NAGYKALDI, ZSOLT J (contact)

PROJECT_TERMS: Accounting;Address;Affect;Alaska Native;Alaska Native population;American Indian Population;American Indians;Attitude;Behavior Therapy;Cancer Diagnostics;Cancer Etiology;cancer health disparity;Caring;Cessation of life;Cherokee Nation;Choctaw Nation of Oklahoma;Clinic;clinical practice;Clinical Trials;Collaborations;Communities;community advisory board;community engaged approach;community setting;design;Development;Diagnostic Services;Dissemination and Implementation;Early Intervention;early screening;Eligibility Determination;Ensure;Equity;Evaluation;evidence base;Eye;Fostering;General Population;Guidelines;Health;health care settings;Health Professional;Health Sciences;Health Services;Health system;Healthcare Systems;Hybrids;implementation evaluation;implementation process;implementation science;implementation study;improved;Incidence;Indigenous;Individual;innovation;Intervention;intervention program;Knowledge;Learning;Link;low dose computed tomography;Lung;lung cancer screening;lung imaging;Malignant neoplasm of lung;Malignant Neoplasms;Measures;member;Methods;Mission;Modeling;mortality;Native American community;Oklahoma;Outcome;outreach;Patient Care;Patients;Persons;pilot test;population health;Primary Care;primary care practice;primary outcome;process improvement;Public Health;Recommendation;referral services;Registries;Research;Resources;routine screening;Rural;Rural Community;scale up;Scientific Advances and Accomplishments;screening;Screening for cancer;screening participation;screening program;secondary outcome;Services;shared decision making;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;social;socioeconomics;synergism;System;Testing;theories;Tobacco;Transportation;treatment services;tribal community;tribal health;tribal healthcare;Tribes;United States;United States Indian Health Service;United States Preventative Services Task Force;uptake;urban Native American;Work;X-Ray Computed Tomography

PROJECT_TITLE: Lung Cancer Screening to Improve Equity in Tribal Communities in Oklahoma (Lung-Screen-Tribal OK)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adoption;Affect;cancer care;Cancer Center;cancer health disparity;Cancer Patient;cancer therapy;care coordination;care fragmentation;care systems;Caregivers;Caring;Case Manager;Clinic;Clinical;Collaborations;collaborative care;Communication;Communication Barriers;Communication Programs;Complex;Effectiveness;effectiveness/implementation hybrid;Ensure;Evaluation;experience;Eye;Financial Hardship;Government;Health;health care service organization;Health Services;Health system;Healthcare Systems;implementation cost;improved;Indigenous;Interruption;Intervention;Knowledge;Lead;Maintenance;Malignant Neoplasms;medical specialties;meetings;Mental Health;Modeling;Native American community;NCI-Designated Cancer Center;novel;Oklahoma;Oncology;Outcome;Participant;patient oriented;Patients;Persons;Population;Primary Health Care;Private Sector;Process;programs;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;satisfaction;Services;social;Specialist;Supportive care;System;telehealthcare;Testing;Time;Training;treatment as usual;treatment planning;trial comparing;tribal health;tribal healthcare;Tribes;United States Indian Health Service;Update;urban Native American;Visit

PROJECT_TITLE: Care Coordination and Communication Program in Oncology for Tribal Health Systems