PROJECT_TERMS: Annual Reports;Biology;Cameroon;career development;Central Africa;Collaborations;Communication;Country;Drug resistance;Ecology;Educational workshop;Ensure;Epidemiology;Florida;Funding Agency;Goals;graduate student;Guidelines;innovation;Insecticide Resistance;Institution;International;International Aspects;international center;Intervention;Malaria;malaria transmission;meetings;Mentors;multidisciplinary;outreach;Postdoctoral Fellow;Procedures;programs;Publications;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Science;Scientist;Site;Structure;success;System;Technology;technology platform;Technology Transfer;Training;Training Activity;Training Support;Travel;United States National Institutes of Health;Universities;vector;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PI_NAMEs: NJI, AKINDEH MBUH (contact)

PROJECT_TERMS: Bioinformatics;Biometry;Biostatistics Core;Cameroon;Collaborations;Computer software;computerized data processing;Data;Data Analyses;Data Collection;data management;Data Management Resources;data platform;data quality;Data Security;data sharing;data standards;Data Storage and Retrieval;Database Management Systems;Databases;Dedications;Development;Educational process of instructing;Educational workshop;Electronics;Ensure;Epidemiology;experience;Florida;genomic data;Goals;Guidelines;innovation;Institution;international center;Lead;Maintenance;Malaria;malaria transmission;Manuscripts;Modeling;Molecular Epidemiology;Procedures;Protocols documentation;quality assurance;Records;recruit;Reporting;Research;Research Activity;Research Design;Research Personnel;Role;Sample Size;Science;Scientist;Secure;Security;Site;Statistical Data Interpretation;System;Technology;Testing;Time;Training;training data;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Data Management and Biostatistics Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-M (J1)]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: LEKE, ROSE  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Anopheles Genus;Automobile Driving;Beds;Behavior;Biological Assay;Bite;Breeding;Cameroon;Characteristics;Chemoprevention;Child;Climate;Clinical;Communities;Complex;Country;Culicidae;design;Development;Disease;Drug resistance;Ecology;Environmental Risk Factor;Epidemic;Epidemiology;Evaluation;evidence base;Evolution;experimental study;Failure;feeding;Genetic;genomic tools;Genomics;Goals;Human;Incidence;Infection;Insecticide Resistance;Insecticides;insight;interdisciplinary approach;Intervention;Knowledge;Longitudinal cohort study;Malaria;malaria transmission;Measures;Membrane;Methods;Molecular;Morbidity - disease rate;mortality;Nature;Parasites;Pattern;Plasmodium falciparum;Plasmodium vivax;Population;Pregnant Women;Prevalence;Preventive treatment;programs;rational design;Research;Resources;response;Seasons;Shapes;Site;spatiotemporal;study population;System;Testing;Time;tool;transmission process;Vaccines;vector;Vectorial capacity;Vivax Malaria;World Health Organization

PROJECT_TITLE: Epidemiological and Entomological Factors Shaping Persistent Malaria Transmission


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: CUI, LIWANG  (contact)

PROJECT_TERMS: Affect;Anopheles Genus;Anti-malarial drug resistance;Anti-malarials;Artemisinins;Cameroon;Case Management;Chemoprevention;chemotherapy;Child;Clinical;clinical efficacy;Collaborations;Combined Modality Therapy;Complex;Country;Culicidae;deep sequencing;Diagnosis;Drug Monitoring;Drug resistance;Ecosystem;Effectiveness;Effectiveness of Interventions;Epidemiology;evidence base;Evolution;Exhibits;Exposure to;Genes;Genetic;Genetic Variation;Genotype;high risk population;Human;In Vitro;Incidence;Infection;Insecticide Resistance;Insecticides;insight;Intervention;Knowledge;knowledge base;Malaria;malaria transmission;Maps;Measures;Mediating;Mediator;Metabolic;Monitor;Mosquito Control;Multi-Drug Resistance;Mutation;novel;Parasite resistance;Parasites;Pattern;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;Policies;Predisposition;Pregnancy;Pregnant Women;Prevalence;Prevention;Preventive;Preventive therapy;programs;pyrethroid;Residual state;Resistance;Resistance development;resistance mechanism;resistant Plasmodium falciparum;Role;Seasons;Sentinel;Shapes;Site;Solid;System;Target Populations;Testing;Time;transmission process;Treatment Efficacy;treatment guidelines;trend;vector;vector competence;vector control;vector mosquito;Vivax Malaria;World Health Organization

PROJECT_TITLE: Understanding the Dynamics of Insecticide and Drug Resistance through Integrated Studies of Vectors, Parasites and Interventions


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Dental, Oral, and Craniofacial Disease;Genetics;HIV/AIDS;Heart Disease;Human Genome;Infectious Diseases;Microbiome;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE As people living with HIV experience longer lifespans (even reaching normal life expectancy) due to highly active antiretroviral therapy, cardiovascular disease (CVD) has emerged as a leading cause of morbidity and mortality. The proposed research project aims to identify potential microbial features, biomarkers, and targets for individual CVD risk prediction and prevention. This holds promise for personalizing medication, such as therapeutic modulation of the microbiome and other interventions, to avert CVD among HIV-infected patients.

PI_NAMEs: WANG, ZHENG  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Advisory Committees;Affect;Algorithms;Area;Arterial Fatty Streak;Atherosclerosis;Bacteria;Bacterial Infections;Biological Markers;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;career;Carotid Artery Plaques;Carotid Atherosclerotic Disease;CD4 Positive T Lymphocytes;Cell Count;cohort;Cohort Studies;CX3CL1 gene;Data;Development;EIF4EBP1 gene;experience;follow-up;forest;Fusobacterium;Fusobacterium nucleatum;Gram-Negative Anaerobic Bacteria;gut bacteria;gut microbiome;gut microbiota;Highly Active Antiretroviral Therapy;Histidine;HIV;HIV Infections;human microbiota;Immunity;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;K-Series Research Career Programs;Life Expectancy;life span;Link;Magnetic Resonance Imaging;Measures;men;Mentors;Metabolism;metabolome;metabolomics;metagenomic sequencing;Metagenomics;microbial;microbiome;microbiome alteration;microbiome analysis;microbiota;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Myocardial;Myocardial dysfunction;novel;Oral;oral bacteria;Oral cavity;oral microbial community;oral microbiome;Participant;pathogenic bacteria;Pathology;Patients;Persons;Pharmaceutical Preparations;Physiology;Play;Population;Prevention;Prize;prospective;Proteins;Proteome;Proteomics;Qi;Research;Research Personnel;Research Project Grants;resident commensals;Resources;Risk Factors;risk prediction;Role;saliva sample;segregation;Serum;Shotgun Sequencing;Shotguns;Songbirds;Source;The Multicenter AIDS Cohort Study;Therapeutic;Tissues;Training;Training Programs;ultrasound;Viral Load result;Woman;Women's Interagency HIV Study;Work

PROJECT_TITLE: Multiomics analysis of the microbiome and subclinical cardiovascular disease in HIV infection

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Obesity;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The objective of this project is to fill the knowledge gap of how an FDA-approved oral formula of small molecules, tRES+HESP, can enhance the new blood vessel formation in treating non- healing wounds in diabetic patients as a topical application. We will evaluate the therapeutic potential of tRES+HESP and its underlying molecular mechanisms in human vascular endothelial cells in Aim 1, and in a newly developed diabetic chronic wound animal model in Aim 2, using a combination of cell culture and animal studies (for causal mechanisms in vitro and in vivo) and cutting-edge proteomics studies (for global analysis of cell signaling & unbiased discovery). The outcome of the proposed research will determine the efficacy of topical application of this formula, tRES+HESP, in diabetic wound healing, and will unveil underlying molecular mechanisms for its beneficial effect.

PI_NAMEs: WANG, JIEMEI ;YI, ZHENGPING  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Affect;Amputation;angiogenesis;Angiogenic Factor;ANGPT1 gene;Animal Model;Animals;blood vessel development;burn wound;Cell Culture Techniques;Cell Physiology;Cell Survival;Cells;Chronic;chronic wound;Clinic;Critical Pathways;Cytoprotection;Data;db/db mouse;Dermal;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;diabetic patient;diabetic ulcer;diabetic wound healing;dietary;Drug Metabolic Detoxication;efficacy evaluation;Endothelial Cells;Enzymes;FDA approved;Gene Expression;Glucose;glycation;Glycolysis;Goals;Health;Human;Impairment;improved;In Vitro;in vivo;Knowledge;Lactoylglutathione Lyase;Literature;metabolic profile;migration;Modeling;Molecular;non-healing wounds;novel;obese person;Oral;Outcome;Overweight;Pathway interactions;Patients;Permeability;Play;Population;Proliferating;Proteins;Proteomics;Protocols documentation;Regimen;Regulation;Reporting;Research;Role;Signal Transduction;small molecule;Stress;success;Testing;Therapeutic;tissue repair;Topical application;trans-resveratrol;translational potential;traumatic wound;Treatment Protocols;Vascular Endothelial Cell;wound;wound care;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Diversity Supplement to “Mechanistic study of Small-molecular Therapy in diabetic Wound Healing”

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Nutrition;Pediatric;Pediatric - AIDS;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In South Africa, the country with the highest HIV prevalence (19%), comorbid problems such as depression, post-traumatic stress, and food insecurity synergistically enhance one another (i.e., syndemic problems) and are associated with worse HIV outcomes such as poorer antiretroviral therapy (ART) adherence and worse viral load. This study proposes to: 1) explore the complex interrelationships between syndemic problems and explore attitudes to potential intervention components; 2) develop a multilevel intervention to address syndemic problems and improve adherence (CBT-SA); 3a) assess the feasibility and acceptability of CBT-SA in a pilot RCT; and 3b) identify barriers and facilitators of CBT-SA engagement. If the CBT-SA intervention is found to be feasible and acceptable, and findings suggest clinically meaningful improvement, the multilevel CBT-SA intervention could be further examined for effectiveness, which could advance the field toward the ending the HIV epidemic initiative.

PI_NAMEs: LEE, JASPER SAMUEL (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Alcohol consumption;antiretroviral therapy;Attitude;Behavioral Medicine;Biometry;Blood;care providers;Caring;Clinic;Clinical;community setting;comorbidity;Complex;Consultations;Counseling;Country;design;Development;Diagnosis;Diagnostic;Dryness;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Epidemic;Evaluation;Evidence based treatment;experience;Food;food insecurity;Food Supplements;Funding;Future;General Hospitals;Goals;Government;Grant;Healthcare;HIV;implementation science;improved;Individual;Influentials;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;Manuals;Massachusetts;medical schools;Mental Depression;Mental Health;Mentors;Mentorship;Modeling;National Institute of Mental Health;National Research Service Awards;negative affect;Nutritional;Outcome;Participant;Patients;Persons;pilot trial;post-traumatic stress;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Poverty;Prevalence;primary outcome;Process;Protocols documentation;Provider;psychologic;Psychologist;Psychology;psychosocial;Public Health;Qualitative Methods;Qualitative Research;Randomized;Research;Research Personnel;Research Priority;Resource-limited setting;Risk;secondary outcome;Services;skills;social;South Africa;Specific qualifier value;Spottings;Structure;substance use;Suggestion;syndemic;System;Testing;theories;therapy adherence;therapy development;Training;Trauma;Travel;treatment as usual;Treatment outcome;treatment strategy;trend;United States National Institutes of Health;uptake;Viral Load result;Withdrawal;Work

PROJECT_TITLE: Developing and piloting a multilevel intervention to address psychosocial and structural syndemics in people with HIV in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-S (03)]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Nanotechnology;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Cancer immunotherapy stimulates a patient’s own immune system to fight off cancer, offering the promise of eradication and a durable cure, however, the majority of breast tumors fail to respond. This project will develop a new targeted nanotherapy strategy to deliver stimulatory compounds to specific immune cell types in breast tumors to convert the tumor to a state that is responsive toward immunotherapies. The project will focus on engineering new therapeutic nanomaterials to maximize safety and effectiveness.

PI_NAMEs: NELSON, ERIK RUSSELL;SMITH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Abraxane;Adjuvant;Agonist;Biocompatible Materials;Biodegradation;Biology;Breast Cancer Model;cancer immunotherapy;cancer therapy;Cancerous;cell type;Cells;Cessation of life;Circulation;Clinical;clinical translation;Combined Modality Therapy;Conjugated Carrier;cytokine;density;design;Dextrans;Disease;Dose;Dose Limiting;drug candidate;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Effectiveness;Endocrine;Engineering;Excretory function;Exhibits;fighting;Frequencies;Goals;Growth;Hepatobiliary;Human;Image;imaging probe;Immune;immune checkpoint blockade;immune stimulatory agent;Immune system;immunogenic;Immunologic Stimulation;Immunomodulators;immunosuppressive macrophages;Immunotherapy;Impairment;improved;Innate Immune Response;innovation;intravenous administration;Kidney;lead candidate;Length;Liver;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metastatic breast cancer;mortality;mouse model;multimodality;nanocarrier;nanocomposite;nanomaterials;nanotherapy;Neoplasm Metastasis;novel therapeutics;Outcome;Paclitaxel;Patients;Pharmaceutical Preparations;Phenotype;Polyethylene Glycols;Polysaccharides;Population;programmed cell death ligand 1;Proteins;radiopharmacology;Regulation;response;Safety;Schedule;Series;Serum;side effect;Solubility;Spleen;Stains;T-Cell Activation;targeted imaging;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Tissues;TLR7 gene;Toxic effect;Toxicology;translational study;Translations;triple negative cancer;triple-negative invasive breast carcinoma;tumor;Tumor Burden;uptake;Work

PROJECT_TITLE: Translational Combinations of Nanocarriers and Blockers for Metastatic Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative South Africa has made progress towards their 95-95-95 goals, yet a substantial proportion of the population do not test regularly. To reach people who otherwise may avoid testing, we propose to build on our successful healer-initiated HIV counseling and testing pilot to conduct a cluster randomized controlled trial in 42 clinical catchment areas to evaluate an expanded Healer-Initiated HIV Testing and Linkage to Care intervention in rural South Africa.

PI_NAMEs: AUDET, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Advertisements;Agreement;antiretroviral therapy;Appointment;Area;care delivery;care providers;care seeking;care systems;Caring;Catchment Area;Client;Clinical;Collaborations;Communities;Community Health Aides;community intervention;cost;cost effectiveness;cost outcomes;cost-effectiveness evaluation;cost-effectiveness ratio;Counseling;Country;disability-adjusted life years;distrust;economic outcome;effectiveness outcome;eligible participant;Event;Goals;Health;Health care facility;Health Care Sector;health care service utilization;Health system;Healthcare;HIV;HIV Seropositivity;Home;Human immunodeficiency virus test;implementation fidelity;improved;incremental cost;incremental cost-effectiveness;Individual;innovation;Intervention;Letters;Link;low socioeconomic status;Maintenance;male;Medicine;member;men;Modern Medicine;Nurses;outreach;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;pilot test;Population;preference;Prevalence;programs;Province;Randomized, Controlled Trials;Research;Resources;Rural;rural area;rural South Africa;self testing;Services;Site;social stigma;South Africa;South African;Sports;standard of care;study population;success;Testing;testing services;testing uptake;Traditional Medicine;Training;treatment adherence;treatment services;trial comparing;uptake;Visit

PROJECT_TITLE: Know your status: A cluster randomized controlled trial comparing healer-initiated HIV counseling and testing to standard of care in rural South Africa


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: RELEVANCE Organophosphate-based nerve agents such as sarin, soman, and venomous agent X are among the most toxic chemicals known for humankind, exposure to which can lead to high mortality and substantial morbidities in survivors. The current medical countermeasures are of doubtful utility for civilian populations as they must be administered within minutes of an attack to be effective. Proposed research aims to evaluate a novel, potent, drug-like inhibitor of an emerging therapeutic target in mice exposed to a prototypical organophosphate and may lead to a delayed treatment for nerve agents-triggered neurotoxicity and long-term neurological sequelae.

PI_NAMEs: JIANG, JIANXIONG  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Ablation;Acetylcholinesterase;Acute;Advanced Development;Adverse effects;Agonist;Amygdaloid structure;Anabolism;analog;Animals;Anti-Inflammatory Agents;anxiety-like behavior;Atropine;Behavioral;benzothiazole;Blood - brain barrier anatomy;Brain;Brain Injuries;chemical threat;Chemical Warfare Agents;cholinergic;Cholinergic Receptors;Cholinesterases;Chronic;Cognitive deficits;Combined Modality Therapy;comorbidity;Convulsants;cost;Cyclooxygenase Inhibitors;cytokine;cytokine release syndrome;Darkness;Development;Diazepam;Dinoprostone;Dose;Electroencephalography;Encephalitis;enzyme structure;Enzymes;experimental study;Exposure to;fluoro jade;Fostering;Funding;Future;Genetic;Glial Fibrillary Acidic Protein;Gliosis;Goals;Half-Life;Health;Hippocampus;Human;humanized mouse;improved;in vivo;Induced Neurons;Infiltration;Inflammation;Inflammatory;inhibitor;Intoxication;Isoflurophate;Lead;lead optimization;Light;Locomotion;Long term disability;Long-Term Effects;Mediating;Medical;medical countermeasure;Microsomes;Midazolam;Mission;Morbidity - disease rate;mortality;Mus;Muscarinic Acetylcholine Receptor;nerve agent;neuroinflammation;Neurologic;neuron loss;Neuronal Injury;neuroprotection;neurotoxicity;Nicotinic Receptors;novel;novel therapeutics;object recognition;open field behavior;Organophosphates;Orthologous Gene;Pathogenicity;Pathologic;Penetration;Pharmaceutical Preparations;pharmacologic;Pilocarpine;Play;Poison;Population;pre-clinical;prevent;programs;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Proteins;Protocols documentation;rational design;Research;Research Support;response;Rodent;Role;Safety;Sarin;Seizures;Series;Serum Albumin;side effect;small molecule inhibitor;social;Soman;Stains;Status Epilepticus;Structure;Survivors;Testing;Therapeutic;therapeutic target;Tight Junctions;Toxic effect;translational potential;United States National Institutes of Health

PROJECT_TITLE: Inhibiting mPGES-1 as a countermeasure to mitigate organophosphate-induced neurotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (54)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Cerebral small vessel disease (CSVD) affects small penetrating arteries, arterioles, capillaries, and venules, causing small subcortical infarcts, lacunae, white matter hyperintensity, enlarged perivascular spaces, cerebral microbleeds, and brain atrophy. CSVD pathology is a leading cause of cognitive impairment and dementia. This project aims to assess the role of monocytes DII4 in CSVD in the context of HIV infection. The study's results will provide essential data that will inform the design of appropriate clinical interventions to slow down the progression of CSVD.

PI_NAMEs: PANG, JINJIANG ;SCHIFITTO, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;Adhesions;Affect;antiretroviral therapy;arterial spin labeling;Arteries;arteriole;Binding;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;brain endothelial cell;brain pericytes;cell dedifferentiation;Cell Physiology;cerebral atrophy;cerebral microbleeds;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;Circulation;Clinical;Cognition;cognitive performance;cognitive testing;cohort;comorbidity;Complex;Conditioned Culture Media;Data;data integration;Data Set;Dementia;density;design;Diffusion;driving force;Endothelial Cells;Equation;extracellular;Female;gain of function;Goals;HIV;HIV Infections;Human;Image;Impaired cognition;Impairment;In Vitro;in vivo;Inflammatory;Intercellular Junctions;interest;Intervention;Ischemia;Lentivirus;Ligands;Lipopolysaccharides;Longitudinal Studies;loss of function;Macrophage;male;Measures;Membrane;Messenger RNA;Meta-Analysis;Methodology;Microcirculation;migration;Modeling;Molecular;monocyte;Motion;multidimensional data;Mus;Neurites;neuroinflammation;neutralizing antibody;notch protein;NOTCH3 gene;novel;Participant;Pathology;Pathway interactions;Penetration;Pericytes;Persons;Phenotype;Physiologic pulse;Plasma;Reporting;Repression;response;Role;Sex Differences;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Source;Specimen;Stimulus;Structure;Subcortical Infarctions;systemic inflammatory response;Testing;TNF gene;transcytosis;Vascular remodeling;vascular smooth muscle cell proliferation;venule;Water;White Matter Hyperintensity

PROJECT_TITLE: Role of Monocyte Delta Like-4 (Dll4) in HIV-Associated Cerebral Small Vessel Disease

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Patient Safety;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: ICARE Project Narrative In many countries including low-and middle-income countries (LMIC), where 90% of adolescents live, adolescents can consent to sexual and reproductive healthcare but require parent/guardian permission to participate in research before age 18. This creates a barrier to adolescent research participation – leading to adolescent underrepresentation and systematic exclusion from biomedical and behavioral studies and subsequent disparities in developmentally tailored HIV prevention research. ICARE will advance research bioethics and biomedical HIV prevention research by evaluating whether early and middle adolescents in Uganda demonstrate adult-level cognitive capacity to consent to biomedical HIV prevention research.

PI_NAMEs: KRENISKE, PHILIP  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;Adult;Age;age difference;Age disparity;age group;age related;AIDS prevention;Area;Authorization documentation;Awareness;behavioral study;Belief;Benefits and Risks;Bioethics;Biomedical Research;Caring;Clinical Assessment Tool;Clinical Research;Clinical Trials;cognitive capacity;Cohort Studies;Communities;Competence;Consent;Country;Data;Decision Making;Development;digital;Disparity;Educational Status;Elements;Eligibility Determination;Environment;Epidemic;Ethics;Exclusion;experience;flexibility;Gender;Health education;health literacy;Health Sciences;Healthcare;HIV;HIV Infections;HIV prevention trial;HIV risk;Household;improved;Incidence;Informed Consent;Infrastructure;Injectable;Institutional Review Boards;interest;Intervention;Intervention Studies;Interview;Knowledge;literacy;low and middle-income countries;Maps;member;Methods;Minor;Modeling;Observation in research;Observational Study;Oral;Parental Consent;Parents;peer;Pharmaceutical Preparations;Policy Maker;population based;pre-exposure prophylaxis;Prevalence;Prevention;Prevention Research;preventive intervention;Privacy;Procedures;Process;programs;Randomized;recruit;Research;Research Ethics;Research Ethics Committees;Research Personnel;Resource-limited setting;Resources;Risk;Risk Behaviors;Safety;Sampling;service delivery;Sex Behavior;sexual and reproductive health;sexual debut;sexual minority status;social stigma;Southern Africa;substance use;Testing;tool;transmission process;Uganda;uptake;Youth

PROJECT_TITLE: Improving understanding of Capacity to consent to sensitive biomedical HIV prevention Research among adolescents in Rakai Uganda (ICARE)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infant Mortality;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections in pregnancy are associated with fetal loss, preterm birth (PTB), and small-for-gestational age, among other adverse outcomes. To date, no RCTs in HIV high-burden settings evaluate perinatal outcomes using different models for antenatal CT/NG and TV testing and no evaluations assess implementation and cost outcomes within routine antenatal care. We propose a 3-arm hybrid effectiveness-implementation RCT among antenatal care attendees in Kisumu and Siaya, Kenya–a region with an HIV prevalence of 20% among women and 10% PTB rate–to compare effectiveness, implementation, and cost outcomes of delivering standard-of-care syndromic STI management vs. CT, NG, and TV testing using Xpert® assays universally vs. only among women without STI symptoms. 1

PI_NAMEs: KINUTHIA, JOHN ;PINTYE, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: accurate diagnosis;Address;adverse birth outcomes;Adverse event;adverse outcome;Affect;Africa;antenatal;antenatal care;Antibiotics;Antimicrobial Resistance;arm;Biological Assay;Birth Rate;Chlamydia trachomatis;Client;Collaborations;compare effectiveness;cost;Cost Analysis;cost effective;cost effectiveness;cost estimate;cost outcomes;Cost-Benefit Data;Costs and Benefits;County;Data;Decentralization;design;Diagnosis;Diagnostic;economic impact;effectiveness outcome;effectiveness-implementation RCT;effectiveness/implementation hybrid;Evaluation;fetal loss;Guidelines;Health;HIV;hospital laboratories;implementation evaluation;implementation outcomes;improved;Incidence;Individual;Infant Mortality;Infection;infection burden;infection management;Interview;Kenya;Laboratories;male;microcosting;Modeling;Molecular;Neisseria gonorrhoeae;Neonatal Mortality;Nucleic Acid Amplification Tests;Nurses;Outcome;Penetration;Performance;Perinatal;perinatal HIV;perinatal morbidity;perinatal outcomes;point of care testing;Policies;policy recommendation;Population;Positioning Attribute;Postpartum Period;Pregnancy;Pregnancy loss;pregnant;Pregnant Women;Premature Birth;Prevalence;primary outcome;Proctor framework;prospective;Public Facilities;Public Health;Quality of Care;randomized trial;Recommendation;Research Infrastructure;response;satisfaction;scale up;secondary outcome;Sexually Transmitted Diseases;Shapes;Small for Gestational Age Infant;standard of care;stillbirth;Symptoms;Syphilis;Testing;treatment arm;Trichomonas vaginalis;United States Preventative Services Task Force;Vertical Transmission;Woman;women's outcomes;Women's prevalence;women's treatment

PROJECT_TITLE: Improving perinatal outcomes among Kenyan pregnant women affected by HIV with an integrated STI testing model

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: GAINESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: OVERALL RESEARCH STRATEGY PROJECT NARRATIVE Increasing insecticide and drug resistance, limited sensitivity of field diagnostic tools and declining investments are urgent contributory factors to the decline in coverage and effectiveness of routine control interventions for malaria control and elimination. Moreover, the true contribution of non-falciparum malaria (NFM) – often presenting as asymptomatic infection – to the global disease burden remains underappreciated. The West- Central Africa Enhancing Malaria Epidemiology Research through Genomics & Translational Systems biology (Émergents [fr.]) ICEMR program is built on a proven research platform and consortium of World Bank, Wellcome Trust, African Academy of Sciences-, and NIH/CDC-funded centers of excellence in Cameroon and Nigeria, and will leverage this expertise to focus on (a) Genomic Epidemiological Mapping (GEM) of non-falciparum malaria (NFM) to quantify the parasite reservoir, measure transmissibility to mosquitoes and evaluate the insecticide resistance status of mosquitoes with NFM parasite infections; (b) Bionomics, Ecology, & Control of Anopheles stephensi (BECA) against the background of endemic primary and secondary anopheline vectors; and (c) Advancing Clinical and Entomological Surveillance (ACES) through emergent diagnostic and translational systems biology platforms to address emerging issues viz. asymptomatic malaria and non-falciparum malaria transmission.

PI_NAMEs: DINGLASAN, RHOEL DAVID RAMOS (contact);HAPPI, CHRISTIAN T.

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Academy;Address;Aedes;Affect;Africa;Africa South of the Sahara;African;Anopheles Genus;Area;Asia;Biological;Breeding;burden of illness;Cameroon;Central Africa;Cessation of life;Cities;Climate;Clinical;Collaborations;Country;COVID-19 pandemic;Culicidae;Data;Democratic Republic of the Congo;Dengue;density;Diagnostic;diagnostic tool;Disease;Djibouti;Drug resistance;Ecology;Effectiveness;Epidemiology;epidemiology study;Funding;genomic epidemiology;Genomics;Ghana;Goals;Habitats;Horns;Human;Incidence;Individual;Infection;Infrastructure;Insecticide Resistance;insight;international center;Intervention;Invaded;Investments;Knowledge;Liver;Malaria;malaria transmission;man;Maps;Measures;mortality;Movement;neglect;Nigeria;North America;Parasites;Parasitic infection;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Population;preference;programs;Public Health;Reporting;Research;Research Infrastructure;Research Priority;Resources;Risk;Science;Sustainable Development;syndemic;Systems Biology;Training;Training and Infrastructure;transmission process;trend;Trust;United States National Institutes of Health;Urbanization;Vacuum;vector;vector mosquito;World Bank

PROJECT_TITLE: West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: CORE 2: ADMINSTRATIVE CORE PROJECT NARRATIVE The Émergents ICEMR is led by an experienced, multinational, interdisciplinary, and complementary leadership team and the implementation of a streamlined, decentralized organizational structure administrative structure. The overarching objectives of the Administrative Core is to provide the leadership, administrative support, and financial management to ensure the success of the Émergents ICEMR, through: (i) effective and efficient administration, coordination and management of all activities associated with the program to ensure that the program milestones are met; (ii) effective and efficient allocation of funds and maintenance of fiscal integrity; and (iii) effective coordination and communication between collaborating Co-Is from academic institutions and research institutes within the network. The Émergents ICEMR Administrative Core will be specifically responsible for leading Coordination of Malaria Surveillance and Core Activities; implementing an Émergents ICEMR Performance & Evaluation Program; and working closely with the NIAID-assembled Scientific Technical Advisory Group.

PI_NAMEs: DINGLASAN, RHOEL DAVID RAMOS (contact)

PROJECT_TERMS: Address;Administrator;Africa;Africa South of the Sahara;Applied Research;Basic Science;bilingualism;Biology;Central Africa;Collaborations;Communication;Consultations;Country;Decentralization;Effectiveness;Ensure;experience;Experimental Designs;Florida;Funding;genomic epidemiology;Genomics;Geographic Locations;Goals;Institution;international center;Leadership;lipidomics;Maintenance;Malaria;mathematical model;meetings;molecular vector;National Institute of Allergy and Infectious Disease;Nature;Occupational activity of managing finances;operation;Organization administrative structures;organizational structure;Performance;Policies;Procedures;Process;Program Evaluation;programs;Progress Reports;Proteomics;Recommendation;Research;Research Institute;Research Personnel;Site;skills;Statistical Models;Stream;Structure;success;Supervision;symposium;Systems Biology;transcriptomics;Universities;Writing

PROJECT_TITLE: Emergents International Centers of Excellence for Malaria Research


PHR: CORE 2: DATA MANAGEMENTAND STATISTICAL CORE PROJECT NARRATIVE Developing and maintaining rigorous data quality and management systems throughout the cycle of any research program is paramount to safeguard data privacy and confidential standards, as well as to ensure the completeness, consistency, and validity of results generated. The Émergents ICEMR Data Management & Statistical Epidemiology (DSME) Core will provide a central source of expertise related to data management, biostatistical analyses, and coordination of secure data exchange and archiving across all Core Components and Research Program Projects. Primary responsibilities of the Core will be to, (a) develop and support implementation of all standard operating procedures (SOPs) related to data collection, security, management, and analyses; (b) support quantitative study design and analytical results (c) coordinate efficient and consistent utilization of data and statistical resources across the projects by providing standard methodology and expert staff support that are readily accessible to all investigators; (d) establish a central, secure integrated data management and storage system; and (e) ensure that analytic methods used for data generated through the program are distributed in a commented, sustainable manner.

PROJECT_TERMS: analytical method;archive data;Archives;Biometry;Central Africa;Clinical;Code;Communication;Country;COVID-19;Data;data archive;Data Collection;data exchange;data integration;data management;Data Management Resources;data pipeline;data privacy;data quality;Data Security;Data Storage and Retrieval;Dedications;Democratic Republic of the Congo;Development;Disease;Ecology;Electronics;Ensure;Epidemiology;experience;Funding;Genbank;Human Resources;Informatics;Information Systems;Institution;International;international center;Lead;Malaria;Medical;metadata standards;Methodology;Modeling;Nigeria;Participant;Personnel Management;Postdoctoral Fellow;Procedures;Program Research Project Grants;programs;public repository;Published Comment;Quality Control;repository;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resources;sample collection;Sample Size;Sampling;Secure;Security;Source;Source Code;Standardization;Statistical Data Interpretation;success;System;Training;training data;Update;Validity of Results;Vector-transmitted infectious disease

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: PROGRAM PROJECT 1 [PP1]: Genomic Epidemiological Mapping (GEM) of non-falciparum malaria (NFM; Pv, Po, and P. malariae [Pm]) to quantify the parasite reservoir, measure transmissibility to mosquitoes and evaluate the insecticide resistance status of mosquitoes with NFM parasite infections. PROJECT NARRATIVE Malaria remains a global health crisis affecting over 241 million people and leading to 627,000 deaths, mostly in children. New tools are necessary to address emerging and drug-resistant strains, the complexity of mixed infections, invasive mosquito species, and the control of insecticide resistant mosquito vectors in support of the goal for malaria elimination. Program Project 1 of the West-Central Africa Enhancing Malaria Epidemiology Research through Genomics & Translational Systems biology (Émergents) International Center of Excellence in Malaria Research (ICEMR) is focused on Genomic Epidemiological Mapping (GEM) of non-falciparum malaria (NFM) to quantify the parasite reservoir, measure transmissibility to mosquitoes and evaluate the insecticide resistance status of mosquitoes with NFM parasite infections in Cameroon and Nigeria.

PROJECT_TERMS: Accounting;accurate diagnosis;Address;Affect;Africa;Anopheles Genus;Anti-malarial drug resistance;asexual;Behavior;Biological;Biological Assay;Bite;Blood;burden of illness;Cameroon;Central Africa;Cessation of life;Child;Clinic;Clinical Distribution;co-infection;Community Health;Complex;Country;Culicidae;Development;Diagnosis;Diagnostic;Disease;Disease Outbreaks;Drug resistance;Epidemiology;epidemiology study;evidence base;Evolution;Exposure to;Failure;Falciparum Malaria;Generations;genomic epidemiology;genomic tools;Genomics;global health;Goals;Human;Individual;Infection;Insecticide Resistance;Insecticides;insight;interest;international center;Kinetics;Knowledge;Life Cycle Stages;light microscopy;Liquid substance;Malaria;Malaria Diagnosis;malaria infection;malaria transmission;Maps;Measures;migration;Molecular;molecular marker;neglect;Nested PCR;Nigeria;Outcome;parasite genome;Parasitemia;Parasites;Parasitic infection;Persons;Plasmodium;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Policies;Population;pressure;Prevalence;Program Research Project Grants;programs;Research;Research Priority;Residual state;Resistance;resistance mechanism;resistant strain;Resolution;rural setting;Saliva;Sampling;Severity of illness;Speed;Spottings;Systems Biology;tool;Traction;transmission process;urban setting;Validation;vector;vector control;vector mosquito;Whole Blood


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PHR: PROGRAM PROJECT 2 [PP2]: Bionomics, Ecology, & Control of An. stephensi (BECA) against the background of endemic primary and secondary anopheline vectors. PROJECT NARRATIVE Malaria remains a global health crisis affecting over 241 million people and leading to 627,000 deaths, mostly in children. New tools are necessary to address emerging and drug-resistant strains, the complexity of mixed infections, invasive mosquito species, and the control of insecticide resistant mosquito vectors in support of the goal for malaria elimination. Program Project 2 of the West-Central Africa Enhancing Malaria Epidemiology Research through Genomics & Translational Systems biology (Émergents) International Center of Excellence in Malaria Research (ICEMR) is focused on the Bionomics, Ecology, & Control of Anopheles stephensi (BECA) against the background of endemic primary and secondary anopheline vectors in Cameroon and Nigeria.

PROJECT_TERMS: Address;Aedes;Affect;Africa;Africa South of the Sahara;Anopheles Genus;Area;Artificial Intelligence;Biology;Breeding;Cameroon;Central Africa;Central African Republic;Cessation of life;Child;Cities;Climate;Commerce;Communities;Country;Culicidae;Data;Dengue;Djibouti;Drug resistance;Ecology;epidemiology study;Ethiopia;Genomics;Ghana;global health;Goals;Habitats;Horns;Human;Infection;innovation;innovative technologies;Insecticide Resistance;Insecticides;international center;Invaded;Kenya;Locales;Location;low and middle-income countries;Malaria;malaria transmission;Maps;Mediating;Modeling;Monitor;Movement;Nigeria;Outcome;Parasitic infection;Persons;Plasmodium falciparum;Plasmodium vivax;Population;predictive modeling;preference;Prevalence;Program Research Project Grants;programs;pyrethroid;Rain;Research;Resistance;resistance mechanism;resistant strain;Risk;Role;Route;Seasons;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sporozoites;Sudan;Surveillance Program;Surveys;Sustainable Development;Systems Biology;tool;transmission process;Urbanization;vector;vector control;vector mosquito;Western Africa;Yemen

PROJECT_TITLE: Area B Transmission


PHR: PROGRAM PROJECT 3 [PP3]: Advancing Clinical and Entomological Surveillance (ACES) through emergent diagnostic and translational systems biology platforms to address emerging issues viz. asymptomatic malaria and non-falciparum malaria transmission in the context of malaria elimination and eradication (MEE). PROJECT NARRATIVE Malaria remains a global health crisis affecting over 241 million people and leading to 627,000 deaths, mostly in children. New tools are necessary to address emerging and drug-resistant strains, the complexity of mixed infections, invasive mosquito species, and the control of insecticide resistant mosquito vectors in support of the goal for malaria elimination. Program Project 3 of the West-Central Africa Enhancing Malaria Epidemiology Research through Genomics & Translational Systems biology (Émergents) International Center of Excellence in Malaria Research (ICEMR) is focused on Advancing Clinical and Entomological Surveillance (ACES) through emergent diagnostic and translational systems biology platforms to address emerging issues viz. asymptomatic malaria and non-falciparum malaria transmission in the context of malaria elimination and eradication (MEE).

PROJECT_TERMS: Address;Adoption;Adult;Affect;Africa;African;Appearance;Area;Artemisinins;asexual;Biological Assay;Biological Markers;Biology;Blood;Bypass;Central Africa;Cessation of life;Child;Clinic;Clinical;Collaborations;cost effective;Country;COVID-19 pandemic;COVID-19 testing;Culicidae;Data;Death Rate;design;Detection;Diagnosis;Diagnostic;diagnostic platform;Diagnostic tests;diagnostic tool;DNA;Drug resistance;Dryness;Epidemiologic Factors;epidemiology study;Failure;Gene Deletion;Genomics;global health;Goals;high throughput screening;Human;Incidence;Individual;Industry;Infection;innovation;Insecticide Resistance;insight;instrumentation;international center;Intervention;Laboratories;lateral flow assay;light microscopy;lipidomics;Liquid substance;Malaria;Malaria Diagnosis;malaria infection;malaria transmission;Medical;Methods;Molecular;multiple omics;Mutation;Nigeria;novel;novel diagnostics;Outcome;Parasite resistance;Parasites;Pathogenesis;Persons;Plasma;Plasmodium;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Policies;Population;Prevalence;Process;Program Research Project Grants;programs;protein biomarkers;Rapid diagnostics;rapid test;Research;Residual state;resistant strain;Role;Saliva;saliva analysis;saliva sample;Sampling;screening;Spottings;Systems Biology;Testing;tool;Training;Translating;transmission process;Treatment Protocols;Validation;vector mosquito;Whole Blood

PROJECT_TITLE: Area C Pathogenesis and Diagnosis


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project will establish an International Center of Malaria Research in Burkina Faso to study the spatiotemporal heterogeneity of malaria and malaria parasite transmission across the Sahelian, Sudano- Sahelian, Sudanian ecozones of Burkina Faso and within differing landscape environments (urban, rural, and migrant/artisanal gold-mining camps). Parasite (species and genetics) and host data (including age and clinical status) will be tightly linked to the complexity of vector species (primary and secondary), their locations near transient or permanent water sources, and translational studies of vector competence, transmission dynamics, and drug and insecticide resistance.

PI_NAMEs: DABIRE, ROCH KOUNBOBR;FOY, BRIAN DAVID (contact);PARIKH, SUNIL

PROJECT_TITLE: Burkina Faso ICEMR


PI_NAMEs: FOY, BRIAN DAVID (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: DZIURA, JAMES DAVID (contact)

PROJECT_TERMS: Address;Anti-malarial drug resistance;Bar Codes;Biometry;Biostatistics Core;Burkina Faso;Certification;Clinical;Clinical Data;Clinical Trials;Collaborations;Collection;Colorado;Data;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data hub;data integrity;data management;Data Management Resources;data platform;data quality;Data Scientist;Data Security;Data Set;data sharing;Data Storage and Retrieval;data submission;database design;Database Management Systems;Databases;Deposition;design;Development;Doctor of Philosophy;electronic data;Ensure;Epidemiology;experience;Faculty;field study;Future;genomic data;health determinants;Health Services Research;Human;Human Resources;Individual;Informatics;Information Technology;Infrastructure;Institution;international center;Label;Lead;Longitudinal cohort;Malaria;member;Methodology;Monitor;multidisciplinary;Parasites;Performance;Phase;Procedures;Process;Protocol Compliance;Protocols documentation;quality assurance;Quality Control;Research;Research Design;Research Project Grants;Resources;Sampling;Science;Secure;shared repository;Site;skills;socioeconomics;spatial epidemiology;spatiotemporal;Specialist;System;Tablets;Testing;timeline;tool;Training;transmission process;Universities;vector;Work

PROJECT_TITLE: ICEMR Data Management Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: OUEDRAOGO, JEAN BOSCO  (contact)

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;Age;Anti-malarials;asexual;Beds;Biological Assay;Blood;Burkina Faso;Cameroon;Cessation of life;Characteristics;Chemoprevention;Circulation;Clinical;Clinical Research;cohort;Collaborations;Complex;Country;Culicidae;Data;Diagnostic;Disease;Drug Monitoring;Drug resistance;Dryness;Enrollment;Epidemiology;epidemiology study;follow-up;Frequencies;Genetic;genetic resistance;Genomics;Goals;Hour;Household;Human;Human Development;improved;Incidence;indexing;Individual;Infection;Insecticide Resistance;Insecticides;Intervention;Life Cycle Stages;Longitudinal cohort;Malaria;malaria transmission;Molecular;molecular marker;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;Natural History;novel;Parasites;Pattern;Performance;Pharmaceutical Preparations;Pilot Projects;Plasmodium;Plasmodium falciparum;Plasmodium malariae;Plasmodium ovale;point-of-care diagnostics;Population;population migration;Predisposition;Pregnancy;Prevalence;Preventive treatment;programs;rapid diagnosis;Regimen;Research Project Grants;Residual state;Resistance;Resistance profile;Rest;Role;rural area;Sampling;Seasons;Site;spatiotemporal;Structure;Sudan;synergism;System;Testing;Time;tool;transmission process;Uganda;Variant;vector

PROJECT_TITLE: Research Project 1:  Epidemiology of malaria species and their natural history in human hosts


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PI_NAMEs: DABIRE, ROCH KOUNBOBR (contact)

PROJECT_TERMS: Adult;Affect;Anopheles Genus;Anti-malarials;Behavior;Biological Assay;Blood;Blood specimen;Burkina Faso;Cities;Climate;Clinical;Collection;Competence;Country;Culicidae;Data;Development;Dose;Drug Exposure;Dryness;Exposure to;feeding;Feeds;Genes;Genetic;Genotype;Goals;Gold;Habits;Heterogeneity;Household;Human;Human Bites;Incubated;Infection;Insecticide Resistance;Insecticides;Ivermectin;laboratory experiment;Link;Malaria;Maps;Measures;Membrane;Methods;Migrant;Mining;next generation;Outcome;Parasites;Parasitic infection;Parasitology;Participant;Pattern;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium ovale;Research Project Grants;Residual state;Resistance;Resistance profile;Rural;rural area;Sampling;Seasons;Site;Skin;Source;spatiotemporal;Sporozoites;success;Testing;time use;transmission process;trend;urban area;USAID;vector;vector competence;vector control;Vector Ecology;Venous;Water

PROJECT_TITLE: Research Project 2:  Vector bionomics, vector competence, and insecticide resistance across distinct ecological zones


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Decades of collective effort in the HIV field have led to a consensus that germline-targeting vaccine approaches offer one of the best methods for effectively eliciting broadly neutralizing antibodies. However, prior efforts have been hampered by the relative rarity and improbable maturation path of targeted precursors. By studying the human germline antibody response to the recently discovered “silent face” gp120 epitope and designing immunogens targeting these germline antibodies, this work will help guide and augment rational vaccine design efforts against HIV-1.

PI_NAMEs: CARTER, JOSH  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Amino Acids;Animal Model;Antibodies;Antibody Repertoire;Antibody Response;Antibody titer measurement;Antigens;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;Cessation of life;Clinical Trials;Combined Vaccines;Complement;complementarity-determining region 3;Complex;Consensus;Cryoelectron Microscopy;design;Development;Electron Microscopy;Engineering;env Gene Products;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Evolution;Exhibits;experimental study;Face;Fostering;Future;Genes;Germ Lines;glycosylation;Goals;HIV;HIV Envelope Protein gp120;HIV vaccine;HIV-1;HIV-1 vaccine;HIV/AIDS;Human;Immune response;Immune system;Immunization;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;improved;In Vitro;in vivo;Individual;Infection;Knock-in Mouse;Length;Libraries;Methods;Monitor;mouse model;Mucous Membrane;Mus;mutant;Mutation;nanoparticle;neutralizing antibody;novel;Outcome;pandemic disease;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Polysaccharides;prevent;Productivity;Protein Engineering;Proteins;Public Health;Publishing;rational design;response;Scheme;Serum;Structure;Structure of germinal center of lymph node;Surface;synergism;Testing;theories;Transgenic Mice;Transgenic Organisms;Vaccinated;Vaccination;vaccination strategy;Vaccine Design;Vaccines;vector;Viral;Viral Antigens;Viral Physiology;Virion;Virus;Work;Yeasts

PROJECT_TITLE: Development and characterization of germline-targeted nanoparticle immunogens toward a novel HIV Env epitope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-J (20)]


ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE – OVERALL AIDS is a worldwide health problem. Hence, the development of a preventive vaccine that elicits broadly neutralizing antibodies against HIV-1 will impact global health significantly.

PI_NAMEs: REINHERZ, ELLIS L (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affinity;Antibodies;Antibody Formation;Antibody Response;Antigen-Presenting Cells;Antigens;arm;autoreactivity;B-Lymphocytes;base;Binding;Binding Sites;biobank;Biocompatible Materials;Bioinformatics;Biological Assay;Bone Marrow;Charge;Chimera organism;Clinical;Cloning;Complex;Cryoelectron Microscopy;Data;design;design and construction;Development;Encapsulated;env Gene Products;Epitopes;Face;Formulation;Fostering;Frequencies;Future;Generations;Genes;Germ Lines;global health;Goals;gp160;Grain;Health;HIV;HIV Envelope Protein gp120;HIV-1;Human;Hydrophobicity;IgG1;IgG3;Immune system;Immunization;immunogenicity;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;immunoreactivity;In Vitro;in vivo;Individual;Infection;Knock-in Mouse;knockin animal;Length;Licensing;Link;Lipid Binding;lipid nanoparticle;Lipids;Liposomes;Mediating;Membrane;Messenger RNA;Methods;Modification;molecular dynamics;Monoclonal Antibodies;monoclonal antibody production;Motion;Mus;Mutation;nanodisk;neutralizing antibody;particle;Patients;Plasma Cells;Polymers;Polysaccharides;prevent;Preventive vaccine;Principal Investigator;Proteins;Proteome;Protomer;Recombinants;Retroviridae;RNA;RNA vaccine;Sampling;Serology;Site;stem;Structure;Technology;technology platform;Texas;tool;Uncertainty;United States National Institutes of Health;vaccination strategy;vaccine formulation;vaccine trial;Vaccines;Viral;Virus Diseases;Writing;X-Ray Crystallography

PROJECT_TITLE: RNA-based HIV-1 chimera vaccines encoding a trimerizing host self-protein protomer linked to a viral MPER-TM segment

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (S2)]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Antigens;Basic Science;biobank;Boston;Budgets;Chimera organism;clinical development;Communication;Data;data sharing;Decision Making;design;Education;Ensure;Fostering;Future;Goals;Group Meetings;HIV-1;immunogenicity;Infection;Institution;Intellectual Property;Link;Logistics;Manuscripts;meetings;Molecular;multidisciplinary;National Institute of Allergy and Infectious Disease;neutralizing antibody;operation;Outcome;Persons;pre-clinical;Preventive vaccine;Productivity;programs;Progress Reports;Proteins;Protomer;Publications;Reagent;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;RNA;RNA vaccine;Series;Site;Structure;symposium;Technology;Teleconferences;timeline;transmission process;Travel;vaccine delivery;vaccine discovery;Vaccines;Viral

PROJECT_TITLE: Administrative Support Core


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: SEAMAN, MICHAEL SCOTT (contact)

PROJECT_TERMS: Animals;Antibody Response;antibody-dependent cell cytotoxicity;Antigens;Apical;Binding Sites;Biological Assay;Cell Line;Chimera organism;Clinical;Clinical Research;Cloning;cohort;Data;design;Development;Epitopes;Evaluation;Genetic Engineering;glycoprotein structure;Goals;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;Humoral Immunities;IgG1;IgG3;Immunize;immunogenicity;improved;in vitro Assay;Individual;Infection;Infection prevention;insight;Kinetics;Knock-in Mouse;knockin animal;Laboratories;Link;Measurement;Membrane;Messenger RNA;Molecular Cloning;Molecular Conformation;Monoclonal Antibodies;Mus;neutralizing antibody;Neutralizing antibody assay;novel;novel strategies;novel vaccines;patient screening;Patients;Phenotype;Polysaccharides;practice setting;preclinical study;Preclinical Testing;Program Research Project Grants;Proteins;Protomer;Reporter;Reproducibility;research clinical testing;RNA;RNA vaccine;Sampling;screening;Serum;Services;Site;Standardization;Structure;Vaccinated;Vaccination;vaccine delivery;vaccine formulation;vaccine strategy;Vaccines;Viral

PROJECT_TITLE: Neutralizing Antibody Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: KIM, MIKYUNG  (contact)

PROJECT_TERMS: Address;Affinity;Antibodies;Antibody Formation;Antigen Presentation;Antigenic Variation;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Proteins;Biochemical;Bone Marrow;Cell Lineage;Cell Separation;Cell surface;Cells;Characteristics;Chimera organism;Collaborations;complement C2a;Computers;Conserved Sequence;Cryoelectron Microscopy;Data;Databases;design;Development;Epitopes;Evaluation;Fostering;Generations;Genes;Genetic;Germ Lines;Goals;gp160;HIV-1;Human;Immune response;Immunity;Immunization;Immunodominant Epitopes;immunogenic;immunogenicity;improved;In Vitro;in vivo;Individual;Infection;Knock-in Mouse;Length;Link;Lipid Binding;lipid nanoparticle;Liposomes;Locales;Membrane;Membrane Proteins;Memory B-Lymphocyte;Messenger RNA;mimicry;Modification;Molecular Conformation;molecular dynamics;Monoclonal Antibodies;monoclonal antibody production;Mouse Protein;Mus;Mutation;nanodisk;Nature;neutralizing antibody;novel;novel vaccines;particle;Plasma;Plasma Cells;Polysaccharides;programs;Proteins;Protomer;Recombinants;Regimen;response;RNA;screening;Serum;Shapes;Specificity;Structure;Surface;Technology;Testing;Vaccination;vaccination strategy;Vaccine Design;vaccine formulation;Vaccines;Variant;Viral;Virion;Virus

PROJECT_TITLE: mRNA-based chimeric membrane protein vaccination strategies directed at the MPER


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Antibodies;Antibody Response;Antigens;arm;B-Lymphocytes;Behavior;Binding;biobank;Cells;Characteristics;Chimera organism;Cloning;Complex;Conserved Sequence;Cryoelectron Microscopy;Data;design;Development;dexterity;Elbow;Elements;env Gene Products;Epitopes;Family member;flexibility;Frequencies;Germ Lines;gp160;Grain;Grant;HIV Envelope Protein gp120;HIV-1;Human;IgG1;IgG3;Image;immunogenic;immunogenicity;Immunoglobulin Somatic Hypermutation;In Vitro;interest;Joints;Kinetics;Length;Link;Lipid Binding;Lipids;Locales;Membrane;Memory B-Lymphocyte;Messenger RNA;Molecular Conformation;molecular dynamics;Molecular Evolution;Monoclonal Antibodies;Motion;Mutation;nanodisk;neutralizing antibody;neutralizing vaccine;particle;Patients;Peptides;Peripheral;Polysaccharides;Production;Proteins;Protomer;Recombinants;reconstitution;RNA;Sampling;screening;Serology;Site;Sorting;Specific qualifier value;Structure;Vaccination;Vaccine Design;vaccine strategy;Vaccines;Viral;X-Ray Crystallography

PROJECT_TITLE: Structural characterization of MPER-TM immunogens


ADMINISTERING_IC: CK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The EMERGEncy ID NET program is a sentinel research network of 12 geographically-diverse, university-affiliated US hospital emergency departments (EDs), which was established in 1995 to address the threat of emerging infectious diseases. Over the past 25 years, the network has worked closely with CDC partners to conduct translational research of emerging infectious diseases with a goal of improving patient care, health outcomes, and infection prevention strategies.

PI_NAMEs: TALAN, DAVID ANDREW (contact)

PROJECT_TITLE: RFA-CK-22-003, Emerging Infections Sentinel Networks (EISN) Research - 2022


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative The project has the potential to significantly reduce community rates of violence among youth age 10 to 24 across two high-burden Denver communities, Far Northeast Denver and Northeast Park Hill. In each community, we will implement and evaluate three innovative strategies for violence prevention that balance theoretical salience, empirical evidence, and practical viability. Together, these strategies, which were selected by our youth and community partners and are informed by the social development model, will help build an infrastructure for violence prevention with universal, selective, and primary interventions that can produce generalizable knowledge to inform violence prevention across the country.

PI_NAMEs: KINGSTON, BEVERLY E. (contact)

PROJECT_TITLE: CE21-005 - Empowering Youth to Realize Equity and Prevent Violence: Youth Violence Prevention Center-Denver


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ALBANY

ORG_NAME: STRATTON VETERANS ADMIN MEDICAL CENTER

PHR: Intracortical microelectrodes enable recording of surrounding neural tissue in the brain to drive external devices for paralyzed Veterans. This proposal details the creation of innovative polymer coatings capable of enhancing neuroprotection following microelectrode implantation to increase the long-term recording potential of intracortical microelectrodes.

PI_NAMEs: GILBERT, RYAN J. (contact)

PROJECT_TERMS: Animals;Anti-Inflammatory Agents;antioxidant therapy;Astrocytes;Attenuated;Biocompatible Coated Materials;Biocompatible Materials;Biodegradation;biomaterial compatibility;Biomaterials Research;Brain;brain tissue;Central Nervous System;central nervous system injury;Characteristics;Chemistry;Cicatrix;Collaborations;Communication;controlled release;Curcumin;Data;design;Development;Devices;Disease;Dose;Drug Delivery Systems;electric impedance;Electrodes;Epilepsy;Estrogens;Event;Failure;Fiber;Film;Free Radicals;Hour;hydrophilicity;Implant;implantation;improved;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Interdisciplinary Study;Kinetics;Lead;Lesion;Libraries;Longevity;macromolecule;Macrophage;Measures;mechanical properties;Mechanics;Microelectrodes;Modeling;Molecular Weight;Nature;Nerve Degeneration;neural;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprosthesis;neuroprotection;Neurosciences Research;neurotransmission;novel;Outcome;Paralysed;performance site;Pharmaceutical Preparations;Pilot Projects;Polymer Chemistry;Polymers;Process;Prodrugs;Property;Publications;Rattus;recruit;Reproducibility;Research Institute;response;Self-Help Devices;Signal Transduction;Stroke;Swelling;Technology;Thinness;Time;Tissue Engineering;Tissues;Veterans;Work

PROJECT_TITLE: Development of Poly (pro-curcumin) Polymer Coatings to Improve Cortical Electrode Biocompatibility

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: The goal of this project is to develop a much-needed objective biomarker in PTSD that will allow more accurate treatment choices and faster evaluation of treatment response for individuals with PTSD. However, current clinical practice is based on subjective assessments and it lacks “objective” PTSD diagnostic and assessment methods based on underlying brain mechanisms of dysfunction. We propose to use quantitative EEG, a non-invasive, cost-effective, totally portable procedure, to precisely measure activity and connectivity between different parts of the brain during awake and sleep states in individuals with and without PTSD. If successful, these objective neuromarkers can be used not only for more accurate detection of the presence and severity of PTSD, but also for a faster and more accurate evaluation of response to current therapy, informing the potential need to switch interventions, and identifying those at high risk for relapse.

PI_NAMEs: MODARRES, MO  (contact)

PROJECT_TERMS: active duty;Address;Anxiety Disorders;awake;Behavioral;Biological Markers;Brain;Cerebral cortex;Chronic;Clinical;Clinical assessments;clinical practice;cohort;comorbidity;Control Groups;cost effective;data repository;Data Set;Databases;Detection;Diagnosis;Diagnostic;Dimensions;Disabling;Disease;Electrodes;Electroencephalography;Employment;Evaluation;Exposure to;Functional disorder;functional outcomes;global health;Goals;Health;health related quality of life;High Prevalence;high risk;improved;indexing;Individual;individual response;Institute of Medicine (U.S.);Intervention;Iraq;Measures;Mental Depression;method development;Methods;military veteran;neurophysiology;novel;novel marker;Occupational;Outcome;Outcome Measure;Patient Self-Report;Patients;Performance;portability;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;Prevalence;Procedures;Prospective Studies;Psychotherapy;Questionnaires;Recommendation;relapse risk;Reporting;Research Personnel;response;Retrospective Studies;Risk;Sensitivity and Specificity;Severities;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep onset;sleep quality;Sleep Stages;Sleeplessness;social;Soldier;Surveys;Symptoms;Techniques;Testing;therapy outcome;Traumatic Brain Injury;traumatic event;treatment choice;Treatment Efficacy;treatment response;United States;United States National Academy of Sciences;United States National Institutes of Health;Veterans;Vietnam;War

PROJECT_TITLE: Neurophysiology Markers of PTSD's Presence, Severity, and Therapy Outcome

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The proposed study is designed to understand the mechanism of LVAD-associated bleeding complications using the state-of-art biophysical and mass spectrometry technologies, and conventional clinical tests. The study objectives are to 1) develop new model to predict for LVAD- induced bleeding 2) investigate the structural changes of the adhesive protein VWF induced by high shear stress found in the LVAD-derived blood flow, and 3) to study how cellular fragments and VWF promote the formation of immature blood vessels.

PI_NAMEs: NASCIMBENE, ANGELO  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acquired von Willebrand disease;ADAMTS;Adhesiveness;Adhesives;Angiodysplasia;angiogenesis;Arteriovenous malformation;Artificial Intelligence;Binding;Biological Assay;biophysical analysis;biophysical techniques;Biophysics;Blood;Blood flow;Blood Platelets;Blood specimen;Blood Vessels;Cardiac;cleavage factor;Clinical;Clinical Management;Clinical Research;Complication;Data;design;Devices;Endothelial Cells;Ensure;Equilibrium;experience;experimental study;Exposure to;extracellular vesicles;Extracorporeal Membrane Oxygenation;Flow Cytometry;Functional disorder;gain of function;Generations;Heart;Heart Diseases;Hemorrhage;Hemostatic Agents;Hemostatic function;Homeostasis;Hyperactivity;Impairment;Implant;implantable device;implantation;improved;In Vitro;in vivo;innovation;insight;Institution;Laboratories;left ventricular assist device;Ligands;Link;longitudinal analysis;loss of function;Machine Learning;Mass Spectrum Analysis;Mediating;Metalloproteases;Methods;Microfluidics;Modeling;Morbidity - disease rate;mouse model;Mucous Membrane;Multivariate Analysis;Mus;Operative Surgical Procedures;Outcome;Pathology;Patients;Pattern;Peptides;Plasma;predictive marker;prevent;Process;Pump;Reporting;Research;Risk;Role;Sampling;shear stress;Source;synergism;System;Techniques;Technology;Testing;Therapeutic Agents;therapeutic target;Thrombosis;Vascular Endothelial Growth Factors;von Willebrand Factor;von Willebrand factor receptor

PROJECT_TITLE: Von Willebrand Factor Hyperactivity, Angiogenesis and LVAD-Induced Bleeding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Cancer;Genetics;Kidney Disease;Precision Medicine;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Clear cell renal cell carcinoma (ccRCC) is a type of cancer characterized by tumors whose growth relies on making new blood vessels, and therefore, ccRCC responds well to drugs that prevent new blood vessels from being made. ccRCC-associated mutations in a DNA-binding protein called PBRM1 improve patient response to these drugs that prevent tumor blood vessel formation, but mutations that do not inhibit PBRM1 activity are common, and the effects of these mutations on patient drug response are unknown. We will determine how mutations that do not disrupt PBRM1 activity affect how ccRCC tumors increase their blood supply so that patients who will not respond are not unnecessarily given drugs with toxic side effects.

PI_NAMEs: BURSCH, KARINA LYNN (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Affect;alternative treatment;angiogenesis;Angiogenesis Inhibitors;Angiogenesis Pathway;ATAC-seq;Benign;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biophysics;blood vessel development;Blood Vessels;Bromodomain;cancer type;Cell Line;Cell Proliferation;Cellular Assay;Chromatin;chromatin modification;Chromatin Remodeling Factor;Clear cell renal cell carcinoma;Clinical;Clinical Trials;Complex;Data;Databases;Disease;DNA;DNA Binding;DNA-Binding Proteins;Drug Exposure;Early Diagnosis;Education;Epigenetic Process;Escherichia coli;Family;Fellowship;Gene Targeting;Genes;genetic signature;Genetic Transcription;genome sciences;Genomics;Goals;Growth;Histone Acetylation;Histones;Hypoxia Inducible Factor;Immune checkpoint inhibitor;improved;improved outcome;in silico;In Vitro;inhibitor;Knowledge;Laboratories;Length;lens;lentivirally transduced;Link;loss of function;loss of function mutation;Lysine;Malignant Neoplasms;Mediating;member;Missense Mutation;Modality;molecular dynamics;mutant;Mutate;Mutation;mutational status;neglect;Neoplasms in Vascular Tissue;normoxia;Nuclear;Nuclear Proteins;Nucleic Acids;Operative Surgical Procedures;Outcome;Output;Pathogenesis;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;Physicians;polybromo;precision medicine;predictive marker;Predisposition;prevent;Production;promoter;protein function;protein structure;Proteins;Reader;Recombinants;Regulation;Renal Cell Carcinoma;Reporting;response;RNA;Role;Scientist;side effect;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;SMARCA4 gene;standard of care;Sucrose;Tail;targeted treatment;Testing;Toxic effect;transcription factor;Transcriptional Regulation;transcriptome sequencing;Treatment-related toxicity;tumor;ubiquitin ligase;unnecessary treatment;Validation;Vascular blood supply;VHL gene

PROJECT_TITLE: PBRM1 bromodomain missense mutations in ccRCC vascular signaling


ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative Organelles are essential cellular compartments with a diverse set of functions. How parental gametes partition their organelles to their progeny and the significance parental organelles play in progeny development remain poorly understood. I take a multi-disciplinary approach using the model organism Drosophila melanogaster to identify maternally deposited organelle proteins that persist in their offspring and track how these long-lived proteins influence germline health of the next generation.

PI_NAMEs: GOODMAN, JAY S (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adult;Age;aged;Aging;Amino Acids;Automobile Driving;Biochemical;Biological;Biological Assay;Cell Nucleus;Cells;Cellular Structures;Chemicals;Complex;Deposition;Deterioration;Development;Diet;Drosophila genus;Drosophila melanogaster;Electron Transport;Embryo;Embryonic Development;Ensure;env Gene Products;Event;Exhibits;experimental study;Fellowship;Female;Fertilization;Generations;Genetic;genetic analysis;Germ Cells;Germ Lines;Health;improved;Inherited;interdisciplinary approach;Label;Larva;male;Membrane;Methionine-tRNA Ligase;Methods;Mitochondria;model organism;Molecular;Molecular Analysis;mutant;nanobodies;neuronal cell body;next generation;novel;Nuclear Envelope;Nuclear Pore Complex;offspring;oocyte maturation;Oocytes;Organelles;Organism;overexpression;Oxidative Phosphorylation;Partner in relationship;Pathway interactions;Phosphorylation;Physiologic pulse;Play;Predisposition;premature;prevent;Process;protein complex;protein degradation;Proteins;Quality Control;Rejuvenation;Repression;Research;Role;Scaffolding Protein;Tissues;Transcript;transmission process;Visualization;young adult

PROJECT_TITLE: Maternal organelle contribution to offspring germline health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: The voluntary control of movement emerges from neuronal activity distributed across many motor controls structures – notably motor cortex, the basal ganglia, and spinal cord. We understand little of how these structures are coordinated, undermining our ability to treat associated movement disorders like Parkinson’s disease and dystonia. In this proposal I will test the idea that the logic of output of cortical projections to basal ganglia and spinal motor centers is coordinated through innervation of defined neuron types that provide cohesion in motor action.

PI_NAMEs: NELSON, ANDERS  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Anatomy;Axon;Basal Ganglia;Basic Science;Behavioral;Brain;brain behavior;brain dysfunction;Calcium;career;cell type;cellular targeting;Clinical;Code;cohesion;Collaborations;Corpus striatum structure;Disease;Dopamine Receptor;Dystonia;Electrophysiology (science);Ensure;experimental study;Foundations;Ganglia;Image;imaging modality;innovative technologies;Interneurons;Intuition;Knowledge;Logic;Maps;Measures;Mediating;Mentorship;Mind;Motor;motor control;Motor Cortex;Motor output;Movement;Movement Disorders;Muscle Contraction;nerve supply;Nervous System;Neurons;Neurosciences;optogenetics;Output;Parkinson Disease;Pathway interactions;Phase;Population;post-doctoral training;presynaptic;programs;Property;Proteins;rabies viral tracing;recruit;Research;Research Personnel;Role;Shapes;Signal Transduction;Spinal;Spinal Cord;Structure;success;Supervision;Synapses;System;Techniques;Technology;Testing;tool;Training;two-photon;Universities;Vertebrates;Work

PROJECT_TITLE: Coordination of Structure and Function in Corticospinal and Corticostriatal Pathways

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative The AKT pathway is often aberrantly activated in breast cancer and acts to promote both tumor growth and the maintenance of an immunosuppressive tumor microenvironment. The proposed studies will investigate the potential of pan-AKT inhibition to enhance the efficacy of immunotherapy strategies in mouse models of triple negative breast cancer and patient-derived organoid models. High throughput screening with a tumor-immune cell co-culture system will be used to identify additional targeted strategies, beyond AKT inhibition, that enhance T-cell mediated tumor cell killing and have the potential to synergize with immune checkpoint inhibition.

PI_NAMEs: BULLOCK, KENNADY  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 4T1;Affect;AKT inhibition;anti-cancer;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD1 therapy;Blood;Breast Cancer Cell;Breast Cancer Patient;candidate identification;CD8-Positive T-Lymphocytes;cell killing;Cell Physiology;Cells;checkpoint inhibition;checkpoint therapy;chemotherapy;Clinic;Clinical;Clinical Trials;Coculture Techniques;Collaborations;Color;Combined Modality Therapy;Data;Data Set;Development;Disease;Distant;drug candidate;Environment;EO771;Excision;Exhibits;experimental study;Failure;FDA approved;Flow Cytometry;Gene Expression Profiling;Genetic;Genomics;Goals;Growth;high throughput screening;human model;Immune;immune activation;Immune checkpoint inhibitor;Immunophenotyping;Immunotherapy;In Vitro;in vivo;inhibitor;lymph nodes;Lymphoid Cell;Maintenance;Malignant Breast Neoplasm;Mediating;Melanoma;Modeling;mouse model;Mus;Myeloid Cells;neoplastic cell;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Organoids;Paclitaxel;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphotransferases;PI3K/AKT;PIK3CG gene;polyoma middle tumor antigen;Population;Pre-Clinical Model;preclinical development;predicting response;Property;Proteomics;Proto-Oncogene Proteins c-akt;recruit;Recurrence;Resistance;resistance mechanism;response;Role;Signal Pathway;Site;Spleen;standard of care;Survival Rate;synergism;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic Effect;Toxic effect;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor-immune system interactions;Tumor-infiltrating immune cells;Unresectable;Up-Regulation;Work

PROJECT_TITLE: Enhancing triple negative breast cancer response to immune checkpoint inhibitor therapy via targeted therapies


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Genome instability is a hallmark of many cancers that both initiates and accelerates disease development. My preliminary data demonstrate that Chk2, an important DNA damage response kinase, protects against genome instability through a novel and mitosis-specific pathway that ensures proper chromosome segregation. Work proposed here will provide molecular insight into this mitotic Chk2-driven pathway, including its regulation, molecular substrates, and potential utility as a pharmacological target in pancreatic cancer.

PI_NAMEs: BLACK, ELIZABETH MAUREEN (contact)

PROJECT_TERMS: Acceleration;Alleles;analog;Apical;ATR gene;Automobile Driving;Award;Cancer Biology;cancer cell;Cancer Etiology;cancer genome;cancer therapy;career;career development;Cell Cycle;Cell Cycle Arrest;Cells;Cessation of life;chemotherapy;chromosome missegregation;Chromosome Segregation;Clinic;Clinical;Communication;Data;Death Rate;Defect;Development;Disease;Disease Progression;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Drug resistance;Educational process of instructing;effective therapy;Engineering;Ensure;Exhibits;experimental study;Failure;Fluorescence Resonance Energy Transfer;Funding;gemcitabine;genome integrity;Genome Stability;Genomic Instability;Goals;in vitro activity;inhibitor;insight;Institution;Interphase;Label;Laboratories;Link;live cell imaging;loss of function;loss of function mutation;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Mentors;Mitosis;Mitotic;Mitotic Chromosome;Molecular;mouse model;Mutation;Neoplasm Metastasis;novel;novel marker;novel therapeutics;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;patient prognosis;pharmacologic;Phosphotransferases;PLK1 gene;Polynucleotide 5'-Hydroxyl-Kinase;Population;Positioning Attribute;Predisposition;prevent;Proteins;Regulation;repaired;Research;research faculty;Research Personnel;response;Role;Running;Science;sensor;Signal Transduction;skill acquisition;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;Training;Treatment Protocols;tumor;Unresectable;Work;Writing

PROJECT_TITLE: Defining the Mitotic Role of Chk2 for the Treatment of Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Lymphatic Research;Neurosciences

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Constructing the brain requires the coordination of several different cell types that permanently reside within the central nervous system. One of these cell types, microglia, is the resident immune cell of the CNS and must travel to and break into the brain before doing its job. We are studying how precursors of microglia colonize the developing brain and differentiate into microglia. This will help us understand the basic biological mechanisms behind how microglia get into the brain and persist, knowledge that is essential to fully understand microglia’s role in brain development and health.

PI_NAMEs: HOOVER, CAMDEN  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Anatomy;Biological;Biology;Brain;brain parenchyma;cell type;Cells;Central Nervous System;Characteristics;Cues;Development;Disease;Embryo;Endocytosis;Gene Transfer Techniques;glial cell development;Glial Differentiation;Goals;Health;Homeostasis;Human;Image;Immune;Immunity;in vivo;Infiltration;Injury;Investigation;Knowledge;Label;Learning;Left;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;lymphatic vasculature;lymphatic vessel;mannose receptor;Maps;Microglia;migration;Modeling;Molecular;molecular dynamics;Molecular Profiling;Mus;Myelogenous;Myelopoiesis;Nature;nervous system development;network architecture;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;Occupations;optogenetics;Pericytes;Pharmaceutical Preparations;Play;Population;Positioning Attribute;Pregnancy;Process;progenitor;Proteins;PUVA Photochemotherapy;receptor;response;response to injury;Role;Source;Testing;tool;Transgenic Organisms;Travel;Venous;Work;Yolk Sac;Zebrafish

PROJECT_TITLE: Investigating Microglia Colonization and Differentiation in the Embryonic Brain


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Intracortical brain-computer interfaces have extraordinary potential to restore full upper extremity function to people with paralysis, but current solutions fall short of the capabilities of able-bodied people. Recent studies have shown drastic improvements predicting motor intention when using decoding algorithms that model neural population dynamics – the rules governing the evolution of neural activity over time – instead of directly decoding the recorded neural activity. This research proposal aims to use dynamics-based decoding to bridge the gaps in performance between intracortical brain-computer interface-controlled hands and able-bodied hands, creating a general-purpose upper extremity prosthesis to restore independence to people with paralysis.

PI_NAMEs: NASON-TOMASZEWSKI, SAMUEL ROSS (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Activities of Daily Living;Address;Algorithms;analog;arm;arm movement;artificial neural network;Automobile Driving;Behavioral;Brain;brain based;brain computer interface;Bypass;Clinical;clinical translation;Cognitive;Computers;Controlled Environment;Data;Devices;dexterity;Evolution;finger movement;Fingers;functional electrical stimulation;functional restoration;Goals;Hand;Hand functions;hand rehabilitation;Home;Human;Implanted Electrodes;improved;Injury;Intention;kinematics;Maps;Measurement;Methods;Modeling;Monitor;Monkeys;Motor;Motor Cortex;Motor output;Movement;Network-based;neural;neural model;Neurons;novel;Outcome;Paralysed;Pattern;Performance;Persons;Population;Population Dynamics;Posture;Prosthesis;Quadriplegia;Quality Control;Quality of life;Research;Research Proposals;robot control;Robotics;Role;Signal Transduction;Site;System;Testing;Time;Translating;Upper Extremity;Variant;Work

PROJECT_TITLE: Restoring Dexterous Hand Function with Artificial Neural Network-Based Brain-Computer Interfaces


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Chronic kidney disease is a progressive, irreversible loss of kidney function affecting up to 37 million Americans and is a significant health burden with increased patient risks for cardiovascular disease, stroke, and early death. Despite the widespread use of therapies aimed at compensating kidney function, these treatments do not reverse chronic kidney disease and only delay the progression to its final stage, end stage kidney disease. The current proposal will elucidate the contributions of T cells to the inflammatory milieu of chronic kidney disease and investigate the mechanisms through which T cells localize to kidney tissue, providing preclinical evidence for potential therapies in the management of chronic kidney disease.

PI_NAMEs: MOORE, KYLE H (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Ablation;Acute Renal Failure with Renal Papillary Necrosis;Adhesions;Adoptive Transfer;Affect;American;Animal Model;Apoptotic;Aristolochic Acids;Binding;Bioinformatics;Cardiorenal syndrome;cardiovascular disorder risk;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Adhesion Molecules;Cell Communication;cell injury;Cells;cellular targeting;Cessation of life;Chronic;Chronic Disease;chronic inflammatory disease;Chronic Kidney Failure;Clinical;Coculture Techniques;Compensation;Creatinine;Critical Thinking;cytokine;Cytolysis;cytotoxicity;Data;Development;differential expression;Disease;E-Cadherin;End stage renal failure;Environment;Epithelial Cells;Epithelium;experimental study;Fibrosis;Flow Cytometry;Foundations;functional loss;Future;Genes;Genetic;Glomerular capsule structure;Glomerular Filtration Rate;Goals;Health;Histology;Human;Immune;Immune system;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunologics;Immunology;improved;In Vitro;in vivo;Induction of Apoptosis;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;Injections;injured;Injury;Injury to Kidney;insight;Intervention;Kidney;Kidney Diseases;kidney fibrosis;knock-down;Knock-in Mouse;Knock-out;Knowledge;Laboratories;Lead;Leukocytes;LoxP-flanked allele;Lung;Lymphocyte;Lymphocytic Infiltrate;Measurement;Measures;Mediating;Mediator;Mission;Modeling;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Nephrons;novel;Pathologic Processes;Patient risk;Patients;pharmacologic;Pharmacologic Substance;Physiology;Population;pre-clinical;receptor;recruit;Renal function;repaired;Research;Risk;Serum;single-cell RNA sequencing;skills;Skin;Small Interfering RNA;Stroke;Structure;Surface;T cell infiltration;T cell regulation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;tissue resident memory T cell;Tissues;Training;Tubular formation

PROJECT_TITLE: Resident Memory T cells in Chronic Kidney Disease


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The head direction (HD) system has proven a fruitful target for neuroscience research into navigation and has spurred significant theoretical advances in modeling the computations performed by neural populations. By incorporating the leading edge of neural recording technology into studies of the HD system in primates during both passive motion and and active locomotion, we will advance not just knowledge of the HD system specifically, but also our understanding of how multiple streams of sensory information are integrated into a coherent whole by populations of neurons distributed across many areas of the brain.

PI_NAMEs: STANLEY, OLIVER RILEY (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 3-Dimensional;Animals;Anterodorsal nucleus of thalamus;Area;Behavior;Behavioral;Brain;Brain region;Brain Stem;Cell Nucleus;Cells;Code;Complex;Computer Models;Cues;Data;density;Dorsal;Electrophysiology (science);Environment;experimental study;Eye;Eye Movements;Face;Fire - disasters;Future;gaze;Generations;Grant;Head;Head Movements;Individual;information processing;insight;Knowledge;Lateral;Life;limb movement;Limb structure;Location;Locomotion;Macaca;Macaca mulatta;Mathematics;Modeling;Monitor;Motion;Motor;Movement;multimodality;multisensory;neural;Neuroanatomy;Neurons;Neurosciences;Neurosciences Research;nonhuman primate;novel;Pattern;Play;Population;Positioning Attribute;Posture;Primates;Rodent;Role;Rotation;Sensory;sensory input;sensory integration;Signal Transduction;Source;spatial relationship;Speed;Stream;System;Techniques;Technology;Testing;treadmill;Update;Vestibular function;Vestibular loss;Vestibular nucleus structure;vestibular system;Visual;visual tracking;Walking;Work

PROJECT_TITLE: Interrogating the Dynamic Neural Computation of the Sense of Direction


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Tuberculosis (TB) is one of the leading causes of death from a single infectious agent, and though the most important risk factor for active disease is co-infection with human immunodeficiency virus (HIV), the mechanisms by which HIV dysregulates the immune response during co-infection are not fully understood. The experiments described in this proposal will use a non-human primate model to examine how co-infection alters immune cell function to lead to greater TB disease in lesions (granulomas), specifically in immune cells that respond to intracellular pathogens (macrophages and CD8 T cells). The insights from these experiments will further our understanding of how HIV impairs the immune response to Mtb, which will inform both vaccine strategies and therapeutics development.

PI_NAMEs: MEDRANO, JESSICA MARIE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;Acceleration;Animal Model;Antigen-Antibody Complex;antiretroviral therapy;Architecture;Automobile Driving;B-Lymphocytes;Bacteria;bactericide;Blood;burden of illness;career;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Count;Cell Physiology;Cells;Cessation of life;Chronic;Clinical;co-infection;Complex;Containment;cytokine;Development;Disease;DNA;effector T cell;Environment;Epidemic;Epigenetic Process;ex vivo imaging;experimental study;Failure;Frequencies;Functional disorder;Future;Granuloma;Granuloma by Site;Growth;HIV;HIV Infections;HIV/TB;Human;Immune;immune function;Immune response;Immunofluorescence Immunologic;Immunology;Impairment;In Situ Hybridization;In Vitro;in vitro Assay;Individual;Infection;Infectious Agent;Inflammatory;Inhalation;insight;Laboratories;Lead;Lesion;Location;Lung;Macrophage;Measures;Mentors;Modeling;Modernization;Morbidity - disease rate;mortality;multidisciplinary;Mycobacterium tuberculosis;Natural Killer Cells;nonhuman primate;Opportunistic Infections;organizational structure;Outcome;pathogen;Peripheral;permissiveness;Persons;Physicians;Play;Population;prevent;Production;pulmonary granuloma;Respiratory Disease;response;Risk Factors;RNA;Role;Scientist;Site;SIV;success;synergism;System;T-Cell Depletion;Techniques;Testing;therapeutic development;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Translating;Tuberculosis;tuberculosis granuloma;tumor-immune system interactions;unethical;vaccine development;vaccine strategy;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: HIV/Mycobacterium tuberculosis co-infection: cellular dynamics in granulomas


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: NARRATIVE This project focuses on largely unexplored mechanisms that multicellular eukaryotes have evolved to grow and protect themselves from death and diseases caused by insufficiency and defects in secretory protein synthesis. To achieve our goals, we will harness the power of the genomic resources and molecular tools of the model plant species Arabidopsis thaliana, which allow genetic and advanced analyses that are impossible to perform in humans and whole-body mammalian models. By studying the signaling pathways of conserved sensors that monitor the homeostasis of secretory protein synthesis, this work will reveal new mechanisms that coordinate growth, stress responses and cell fate decisions and thus improve our understanding of human growth and disease.

PI_NAMEs: BRANDIZZI, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Biological;biological adaptation to stress;Biological Models;Body System;Cell Death;Cell Death Process;Cell Differentiation process;Cell Line;Cells;Cessation of life;Chronic;Defect;design;Diabetes Mellitus;Disease;Effector Cell;Endoplasmic Reticulum;endoplasmic reticulum stress;environmental stressor;Eukaryota;forward genetics;frontier;Genetic;genetic resource;Genetic Screening;genome resource;Goals;Growth;Homeostasis;Housekeeping;Human;improved;In Vitro;in vivo;Knowledge;Life;Link;Malignant Neoplasms;Medical;Membrane;misfolded protein;model organism;Modeling;Molecular;Monitor;Mouse-ear Cress;Nerve Degeneration;novel;Organism;Pathway interactions;Phosphorylation;Physiological;Plant Model;Plants;Production;Protein Biosynthesis;protein folding;Protein Kinase;Proteins;Research;Resistance;response;Ribonucleases;Role;secretory protein;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stress;targeted treatment;therapeutically effective;tool;transcription factor;Work

PROJECT_TITLE: Unfolded protein response in the model species Arabidopsis thaliana