ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Disability Research;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Patient Safety;Peripheral Neuropathy;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Relevance Chemotherapy leads to peripheral neuropathy (PN) in 90% of patients and is linked to disability and falls; however, we know little about the patterns and predictors of PN and subsequent falls. The knowledge gained from this study could provide clinical practice with best practice strategies to prevent falls in persons with PN.

PI_NAMEs: WINTERS-STONE, KERRI M (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Acceleration;Address;Adverse effects;Aftercare;Age;aggressive therapy;Attention;Behavioral;Body mass index;cancer care;Cancer Patient;Cancer Survivor;cancer therapy;Caring;Characteristics;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chemotherapy-Oncologic Procedure;Clinical;Clinical assessments;Clinical Pathways;clinical practice;Clinical Practice Guideline;comorbidity;Data;Development;disability;Disability prevention;disability risk;Dose;Early Diagnosis;Early Intervention;Equilibrium;Etiology;Fall prevention;fall risk;falls;follow-up;functional decline;Functional impairment;Gait;Gait abnormality;Goals;Growth;Guidelines;Health Care Costs;high risk;Impairment;improved;innovation;Intervention;Knowledge;Life;Link;Long-Term Survivors;Longitudinal Studies;Malignant Neoplasms;Measures;Medication Management;men;Mobility decline;Modeling;Monitor;Neuropathy;neurotoxic;novel;Obesity;Oncology;Pain management;patient safety;Patient Self-Report;Patients;Pattern;Peripheral Nervous System Diseases;Persons;Phase;Physical activity;Physical Function;Prevention strategy;productivity loss;Provider;Quality of life;Recording of previous events;Recovery;rehabilitation strategy;Rehabilitation therapy;Reporting;Resources;Risk;Risk Factors;sex;shared decision making;sociodemographics;Survivors;survivorship;symptom management;Symptoms;Technology;Testing;treatment planning;Treatment Side Effects;Treatment-Related Cancer;Woman;women's treatment

PROJECT_TITLE: Patterns and predictors of symptoms, falls, and functioning across treatment and recovery in patients treated with neurotoxic chemotherapy for cancer

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_STATE: OR

PHR: Project Narrative Sleep wake disturbances occur in over 50% of the 50,000 children surviving traumatic brain injury (TBI) hospitalization each year and lead to poor quality of life, though few interventions exist to treat this important morbidity. Children with TBI also suffer cognitive impairments that could be compounded by poor sleep, particularly with respect to executive functions like memory and attention that are vital for academic achievement and optimal development. This proposal will determine the relationship between sleep wake disturbances and important executive functions after TBI, as well as test an early sleep management intervention as a target to improve outcomes in these vulnerable children.

PI_NAMEs: WILLIAMS, CYDNI NICOLE (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Academic achievement;acceptability and feasibility;actigraphy;Acute;Acute Brain Injuries;Address;Affect;aged;Anti-Inflammatory Agents;Attention;Behavior;Behavior Therapy;Brain;career development;Characteristics;Child;Child Care;Childhood;Chronic;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;cohort;cost;Critical Care;Critical Illness;Critically ill children;Data;Data Analyses;Development;Early Intervention;effective intervention;effective therapy;Effectiveness;Equipment and supply inventories;evidence base;Executive Dysfunction;executive function;follow-up;Functional disorder;Funding;Goals;healing;Health;high risk;Hospitalization;Impaired cognition;Impairment;improved;improved outcome;improvement on sleep;Inflammatory;Injury;Intervention;Linear Regressions;longitudinal analysis;Longitudinal cohort study;Maintenance;Measures;Melatonin;Memory;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Modeling;modifiable risk;Monitor;Morbidity - disease rate;multidisciplinary;multimodality;Neurons;Oregon;Outcome;patient oriented;Pediatric Intensive Care Units;pediatric traumatic brain injury;Performance;Phenotype;Physicians;poor sleep;prevent;Prevention;Problem behavior;Productivity;Property;prospective;Prospective, cohort study;psychosocial;psychosocial outcome;Publications;Quality of life;Questionnaires;randomized placebo controlled trial;Randomized, Controlled Trials;Recording of previous events;Recovery;Research;Research Proposals;Risk Factors;Science;skill acquisition;Sleep;Sleep Disorders;Sleep disturbances;standard care;Survivors;Targeted Research;TBI Patients;Testing;Training;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States National Institutes of Health;Universities;Work;Wrist

PROJECT_TITLE: Sleep Management And Recovery after Traumatic Brain Injury in Kids (SMART-Kids): Evidence for targeting sleep to improve outcomes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Pain Research;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Methods to monitor acute cannabis effects in real-time could reduce potential cannabis-related harm by raising a person's awareness of possible cannabis-related impairment, for example, on psychomotor performance (e.g., slowed response). Toward this goal, this project will collaborate with individuals who use cannabis for therapeutic purposes in monitoring, using their smartphone, the acute therapeutic and adverse effects of cannabis use, and will combine this fine-grained data with follow-up over 1-year because cannabis effects may differ at shorter (daily) and longer time scales (over months). In line with NIDA priorities, this project's novel combination of smartphone symptom monitoring and longer-term follow-up will guide the creation of real-time interventions to reduce cannabis-related impairment and harm.

PI_NAMEs: CHUNG, TAMMY  (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Accelerometer;Acute;Adverse effects;Age;alcohol and other drug;Alcohols;Anxiety;anxiety symptoms;Automobile Driving;Awareness;Cannabis;Cellular Phone;chronic pain;Cognitive;cognitive function;Collaborations;computerized;Data;Data Collection;design;Development;Digit structure;driving skills;Drug usage;Ecological momentary assessment;Exclusion;Female;follow-up;Frequencies;gender difference;Goals;Grain;Impairment;improved;Individual;interest;Intervention;Intoxication;Life;Link;marijuana use;marijuana use disorder;Measures;Mediating;Mediation;Medical;Medical Marijuana;Methods;mhealth interventions;Modeling;Monitor;National Institute of Drug Abuse;novel;Outcome;Pain;pain symptom;Participant;Patient Self-Report;Patients;Performance at work;Persons;Pharmaceutical Preparations;Psychomotor Performance;Reaction;Reaction Time;recruit;Reporting;response;Risk;Risk Reduction;saliva sample;salivary assay;self-reported anxiety;sensor;side effect;Speed;Substance Use Disorder;Symptoms;Telephone;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;Time;Visit

PROJECT_TITLE: Monitoring acute and longer-term effects of cannabis on psychomotor performance in daily life in medical cannabis patients

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This application uses new mouse models of Barth syndrome generated in our laboratory through editing a patient’s TAFAZZIN gene mutation into the mouse genome, as well as a floxed Tafazzin conditional knockout mouse to identify and characterize novel signaling pathways responsible for impaired cardiovascular function in this frequently lethal X-linked mitochondrial disease. Our patient-specific and heart-restricted approach to the study of Barth syndrome is designed to enhance our understanding of Tafazzin’s role in cardiomyocyte morphogenesis, non-compaction cardiomyopathy, metabolic reprogramming during both in utero and postnatal mitochondrial dysfunction and heart failure.

PI_NAMEs: CONWAY, SIMON JAMES (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;5'-AMP-activated protein kinase;Active Sites;Adult;Affect;Anabolism;Animal Model;Arrhythmia;Autophagocytosis;basal insulin;Binding;Birth;Cardiac;Cardiac Myocytes;Cardiolipins;Cardiomyopathies;Cardiovascular Physiology;Cardiovascular system;Cells;Cessation of life;Characteristics;Child;Chimera organism;Chronic;Clinical;clinically relevant;Compensation;conditional knockout;Congenital Abnormality;CRISPR/Cas technology;Data;Data Correlations;Defect;design;Dilated Cardiomyopathy;Disease;Enzymes;Exhibits;fetal;fetal loss;Functional disorder;Future;Gene Mutation;General Population;Generations;Genes;Genetic Diseases;Genotype;Glucose;Glucose Transporter;Glycogen;Granulopoiesis;Health;Heart;heart defect;Heart failure;heart function;Homeostasis;Human;Human Genetics;Hypoglycemia;Immune system;Impairment;in utero;in vivo;Infertility;Inherited;insight;Insulin;Intervention;knock-down;Knockout Mice;Laboratories;Left ventricular non-compaction;Life;Link;LoxP-flanked allele;male;Measures;Mediating;Mediator;Metabolic;Metabolic stress;Missense Mutation;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Molecular;monolysocardiolipin;Morphogenesis;Morphology;mouse genome;mouse model;multidisciplinary;Mus;Muscle Cells;Musculoskeletal System;mutant;Mutation;Myocardial;Myocardium;Myoglobin;Myopathy;Nature;Neutropenia;Non-compaction cardiomyopathy;novel;Online Mendelian Inheritance In Man;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathogenesis;Pathology;Patients;personalized therapeutic;pharmacologic;Phenocopy;Phenotype;postnatal;precision medicine;premature;prenatal;Proteins;Replacement Therapy;Research;Role;sensor;Sepsis;Serum;Severities;Signal Pathway;Signal Transduction;skeletal;skeletal muscle weakness;small hairpin RNA;Symptoms;Syndrome;TAZ gene;Testing;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;Up-Regulation;Variant;Waxes;Work

PROJECT_TITLE: Tafazzin and metabolic reprogramming during cardiomyopathy

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Precision Medicine

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE In this grant application, we will develop a novel intracoronary imaging catheter system combining two complementary optical modalities for tissue characterization. The proposed system will be able to simultaneously assess structural and biomolecular changes in coronaries arteries that are associated with atherosclerotic plaque progression and sudden cardiac events. This approach will allow interventional cardiologists to detect plaque that may cause future major adverse cardiovascular events in patients with coronary artery disease – the leading cause of death in the US. Results from this study will support the advancement of new paradigms that could utilize the hybrid catheter system to guide interventional decision making in the catheterization lab, thus patients undergoing percutaneous coronary intervention may benefit from personalized treatment of these plaques and improved outcome.

PI_NAMEs: BOUMA, BRETT E;MARCU, LAURA  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: acute coronary syndrome;Address;Applications Grants;Arterial Fatty Streak;Authorization documentation;Biochemical;calcification;Cardiac;Cardiac Catheterization Procedures;Cardiovascular system;Catheterization;Catheters;Cause of Death;Cholesterol;Classification;Clinical;Clinical Management;Collagen;Collection;Consent;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary lesion;Data;data acquisition;Data Set;Databases;Decision Making;design;detector;Development;Devices;diagnostic value;Documentation;Engineering;Evaluation;Event;experience;Extracellular Matrix;Family suidae;first-in-human;Fluorescence;fluorescence lifetime imaging;Foam Cells;Future;Goals;Heart Transplantation;Histologic;Histopathology;Human;human data;human imaging;human subject;Hybrids;Image;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging system;Imaging Techniques;improved;improved outcome;in vivo;information display;innovation;insight;Intervention;Knowledge;Label;Lateral;Lesion;Link;Macrophage;Measurement;meetings;Microscopic;Modality;Modeling;Morphology;novel;optical frequency domain imaging;Optical Tomography;Optics;Pathology;Patient Admission;Patients;percutaneous coronary intervention;Performance;personalized management;personalized medicine;polarimetry;preclinical evaluation;Preclinical Testing;Prevention;Procedures;Process;prototype;Reproducibility;Resolution;Risk Management;Rupture;Sampling;solid state;Specimen;Speed;statistics;Structure;System;Techniques;Testing;Time;tissue mapping;Tissues;tomography;validation studies;Visual

PROJECT_TITLE: Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Inequities in depression and its diagnosis and treatment among rural-dwelling minority seniors, which are often rooted in place-based social and environmental factors (e.g., economic insecurity, histories of trauma, and gaps in health and social services), present a major public health burden. This K99/R00 application proposes to integrate my expertise in participatory qualitative research and implementation science with new knowledge in rural mental health research, quantitative and mixed-method designs, and intervention development, in order to enhance my independence as a researcher focused on addressing these social and environmental causes of health disparities, which the National Institute of Minority Health and Health Disparities has identified as a major priority. The proposed R00 research will elucidate how place-based vulnerabilities and protective factors shape experiences of depression among rural American Indian and Latinx elders in New Mexico, and contribute to the development of a plan for a community-driven place-focused intervention to reduce mental health disparities in this and other marginalized populations.

PI_NAMEs: JARAMILLO, ELISE TROTT (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: access disparities;Address;Advocate;Affect;Age;Aging;aging population;American Indians;care systems;Characteristics;Chronic;Colonialism;Communities;Community Health;community led intervention;Community Psychology;Community Services;comorbidity;Complement;Complex;Data;Data Analyses;depressive symptoms;design;Development;Diagnosis;Disadvantaged;Disparity;Economics;Educational workshop;Elderly;Environmental Risk Factor;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;Evaluation Studies;experience;Family member;farmer;Federally Qualified Health Center;Food;Friends;Fright;Funding;Future;Gender;Geography;Goals;Health;health care disparity;health care service;health care service organization;health care settings;health disparity;health equity;health inequalities;Health Planning;Health Services;Health system;Healthcare;help-seeking behavior;Impaired cognition;implementation science;implementation study;improved;Individual;Inequity;Insurance Coverage;Interdisciplinary Study;Intervention;intervention mapping;Interview;Knowledge;Latinx;Link;marginalized population;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentally Ill Persons;Mentors;Methodology;Methods;Minority;Minority Groups;Minority Status;mortality;National Institute on Minority Health and Health Disparities;New Mexico;Pathway Analysis;Physical environment;Policy Making;Population;Process;protective factors;Protocols documentation;Provider;Public Health;Qualitative Research;Race;racial minority;Recording of previous events;Research;Research Institute;Research Personnel;resilience;Role;Rural;rural Americans;rural area;Rural Community;Rural Health Services;Rural Minority;Rural Population;rural residence;rurality;safety net;Scholarship;Science;Services;Shapes;skills;social;social culture;Social Environment;social factors;social health determinants;social stigma;social structure;Social support;Social Work;stem;structural determinants;Structure;Surveys;System;Targeted Research;Texas;theories;therapy development;Training;Translating;Transportation;Trauma;tribal Nation;Underserved Population;United States;United States Indian Health Service;United States National Institutes of Health;Universities;Well in self

PROJECT_TITLE: Place-based Strengths and Vulnerabilities for Mental Wellness among Rural Minority Seniors


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative  Inhibition of intestinal mucosal growth occurs commonly in patients who undergo massive gastrointestinal surgical resections and disrupted epithelial adaptation by inhibiting mucosal growth impairs gut barrier function and leads to the translocation of luminal toxic substances and bacteria to the bloodstream. Effective therapies to preserve the gut epithelium integrity are limited, because of poorly understood mechanisms underlying the regulation of gut mucosal renewal in stressful environments. Studies proposed this project will identify the roles of altered function of Paneth cell/intestinal stem cell niche by RNA-binding proteins and long noncoding RNAs in the control of gut mucosal growth/adaptation in patients with critical surgical disorders and will create a fundamental basis for development of new therapies to protect the gut epithelium integrity in the clinical setting.

PI_NAMEs: WANG, JIAN-YING  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Bacteria;Bacterial Translocation;base;Binding;Blood Circulation;Cell Maintenance;Cell Physiology;Cessation of life;Clinic;Clinical;Complex;Defect;Development;Disease;effective therapy;EGF gene;Environment;Epithelial Cells;Epithelium;Event;Excision;Functional disorder;Funding;gastrointestinal epithelium;Gastrointestinal Surgical Procedures;Gene Expression;Gene Expression Profile;Goals;Growth;gut homeostasis;Gut Mucosa;Health;Homeostasis;Host Defense;Human;HuR protein;Ileitis;Impairment;in vivo;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Ischemia;Knock-out;Knowledge;Ligands;Membrane;Mesentery;Messenger RNA;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;mRNA Stability;mRNA Translation;Mucous Membrane;Multiple Organ Failure;notch protein;novel;novel therapeutics;Operative Surgical Procedures;Paneth Cells;Pathogenesis;Patients;Poison;posttranscriptional;preservation;Process;prohibitin;Proteins;Regulation;Reperfusion Therapy;response;RNA;RNA-Binding Proteins;Role;self-renewal;Sepsis;Signal Transduction;Small Intestines;Starvation;stem cell niche;stem cell proliferation;stem cells;Stress;Surface;Testing;Therapeutic;therapeutically effective;Total Parenteral Nutrition;Transcription Process;Translations;Untranslated RNA;WNT3 gene

PROJECT_TITLE: Intestinal Mucosal Growth in Health and Surgical Diseases

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Estrogen;Genetics;Hematology;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Oral contraceptives increase risk for the formation of blood clots in pre-menopausal women. This proposal will examine how oral contraceptives interact with genetic and non-genetic factors to alter the biochemistry of blood coagulation using biochemical studies, and cross-sectional and longitudinal clinical cohorts.

PI_NAMEs: MAST, ALAN E (contact);SHEEHAN, JOHN PATRICK

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: activity marker;age group;Anticoagulants;Binding Proteins;Biochemical;Biochemical Markers;Biochemistry;Biological Assay;Biological Markers;biomarker identification;Blood coagulation;Blood Coagulation Factor;Blood donor;Blood specimen;Clinical;Clinical Research;clinically significant;Coagulation Process;cohort;Contraceptive Usage;Data;Decision Making;density;Disease;endometriosis;Estrogens;Event;evidence base;Exhibits;experimental study;Factor IXa;factor V Leiden;Female;Female Adolescents;Gene Chips;Generations;Genes;Genetic;Genetic Markers;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;Goals;Hemostatic Agents;high risk;High Risk Woman;hormone therapy;Hormones;Human;Hyperactivity;Individual;Injections;innovation;Liver;Longitudinal cohort;Measurement;Measures;Mediating;Menorrhagia;Modeling;Mus;non-genetic;Oral Contraceptives;Oral Examination;Pathway interactions;Plasma;Plasma Proteins;Polycystic Ovary Syndrome;Predictive Value;Predisposition;Premenopause;Production;prospective;Protein S;Proteins;Questionnaires;Recombinants;Recording of previous events;Resistance;response;Risk;Role;Sampling;Severities;Signal Transduction;synergism;System;Techniques;TFPI;Thrombin;Thrombophilia;Thrombosis;Thrombus;Time;trait;United States;Variant;venous thromboembolism;Withdrawal;Woman;young woman

PROJECT_TITLE: TFPI, Protein S, and Plasma FIXa in Hormone-Induced Hypercoagulability

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Exosome therapy is a promising strategy to tissue regeneration. However, suboptimal exosome homing to the injured tissue hampers the efficiency and outcome of exosome therapy. In the proposed study, we employ platelet and vascular biology to achieve targeted delivery of therapeutic exosomes in the injured heart tissue.

PI_NAMEs: CHENG, KE  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute Lung Injury;Acute myocardial infarction;adult stem cell;Animal Model;Animals;Applications Grants;Binding;Biological;Biological Assay;Biology;Biomedical Engineering;Blood flow;Blood Platelets;Blood Vessels;Body Fluids;cancer cell;cardiac repair;Cardiovascular Diseases;Cardiovascular Models;cell type;Cells;cellular engineering;Chemical Engineering;Clinical Trials;Collagen;combat;Development;Dimensions;Dose;early phase clinical trial;Endothelium;engineered exosomes;Engineering;Ensure;exosome;experimental study;Exposure to;extracellular vesicles;Extravasation;fabrication;Family suidae;Fibronectins;first-in-human;graduate student;Grant;Heart;Heart Injuries;Homing;Human;Hybrids;In Vitro;Infusion procedures;injured;Injury;insight;Interdisciplinary Study;interest;Intravenous;intravenous injection;Ischemia;ischemic injury;Lipid Bilayers;Liver;Lung;Lung Diseases;Macrophage;Mechanics;Mediating;Membrane;Mesenchymal Stem Cells;minority student;Mononuclear;mouse model;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;Names;nanoparticle;nanosized;Nature;novel strategies;Organ;Outcome;Paper;paracrine;particle;Patients;Phagocytes;porcine model;Postdoctoral Fellow;preclinical study;programs;Property;recruit;Regenerative Medicine;Regenerative research;repaired;Reperfusion Therapy;replacement tissue;Research;Rodent Model;Safety;Science;Scientist;Societies;Spleen;stem;stem cell delivery;stem cell exosomes;stem cells;Surface;System;targeted delivery;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;tissue regeneration;Tissues;Toxic effect;training opportunity;United States National Institutes of Health;uptake;Ventricular;von Willebrand Factor

PROJECT_TITLE: Harnessing Platelet-Endothelial Interactions for Exosome Delivery

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Nutrition;Obesity;Prevention;Sleep Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Chronic sleep deprivation is a crisis and growing epidemic both nationally and globally, the cardiovascular consequences of which need further investigation according to the American Heart Association. This proposal aims to investigates both short sleep duration and sleep irregularity as potentially modifiable risk factors for vascular inflammation and visceral adiposity (a known contributor to cardiometabolic disease risk) measured using novel, multi-modality imaging. The long-term goal is for Dr. Kundel to become a successful independent investigator in sleep research, elucidating mechanistic pathways linking sleep deprivation to cardiovascular disease, and developing preventative strategies and therapeutic interventions (i.e., sleep extension trials) to gain deeper insights into mechanisms by which sleep modulates inflammation.

PI_NAMEs: KUNDEL, VAISHNAVI  (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: Abdomen;Academy;actigraphy;Adipose tissue;Adult;Age;American;American Heart Association;Atherosclerosis;Award;biobank;Biological Markers;biomarker identification;Blood;Blood Vessels;Body mass index;Body System;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;career development;Carotid Arteries;Chest;Chronic;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;design;Development;Development Plans;Diagnosis;disorder risk;Doctor of Philosophy;early detection biomarkers;Environment;Epidemic;epidemiology study;Event;Exclusion;experience;Faculty;fluorodeoxyglucose positron emission tomography;Foundations;Funding;Future;Goals;Grant;Health;Home;Hour;Hybrids;Image;imaging biomarker;indexing;Inflammation;Inflammatory;inflammatory marker;insight;Interdisciplinary Study;Internal Medicine;Investigation;K-Series Research Career Programs;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediating;medical schools;Medicine;Mentors;Metabolic;modifiable risk;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Multimodal Imaging;multimodality;Myocardial Infarction;Neck;novel;novel marker;Obesity;Observational Study;Obstructive Sleep Apnea;Outcome;Pathway interactions;patient oriented research;Patient Recruitments;Patient Self-Report;patient subsets;Patients;PET/CT scan;Pilot Projects;Population;Positron-Emission Tomography;Prevention strategy;prognostic indicator;Race;Recommendation;recruit;Reproducibility;Research;Research Design;Research Personnel;Residual state;Risk Factors;Role;Science;sex;Sleep;Sleep Deprivation;Sleep disturbances;sleep onset;sleep pattern;sleep physiology;Solid;Specimen;Standardization;Stroke;success;systemic inflammatory response;Systems Biology;targeted treatment;Testing;Therapeutic Intervention;Thoracic aorta;Time;Training;trend;uptake;vascular inflammation;Visceral

PROJECT_TITLE: Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: FLAGSTAFF

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: Narrative Bridging Arizona Native American Students to Bachelor’s Degrees, is designed to increase the number of Native American students from federally recognized tribes completing baccalaureate degrees in the biomedical and behavioral sciences at Northern Arizona University by providing a unique transfer program for students originating from Coconino Community College that is academically sound, highly engaging and seamless. This program will increase the number of Native Americans trained in the area of biomedical and behavioral sciences which are of importance to Native American communities.

PI_NAMEs: INGRAM, JANI CHERI (contact);MCKINNEY, MELINDA

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Accreditation;Apache;Arizona;Bachelor's Degree;Behavioral Sciences;Border Community;Cancer Education Grant Program;career;Communication;community college;Counseling;Degree Completion;Degree program;Development;Education Projects;Enrollment;Evaluation;experience;Financial Support;Geographic Locations;Goals;Grant;hands on research;high school;Hualapai;improved;Institution;matriculation;Mentorship;Modification;Native Americans;Navajo;Participant;Pathway interactions;programs;recruit;Reproducibility;Research Personnel;Resource Sharing;role model;Science;Structure;Students;Training;training opportunity;tribal lands;Universities;Writing

PROJECT_TITLE: Bridging Arizona Native American Students to Bachelor Degrees

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The proposed research is relevant to public health and specifically to NIH’s mission to seek fundamental knowledge about the behavior of living systems and apply that knowledge to enhance health and reduce the burden of disease. Our experiments will fill a gap in our understanding of basic Helicobacter pylori physiology and metabolism during colonization. This work will pave the way for new treatments that enhance antibiotic cure of H. pylori.

PI_NAMEs: OTTEMANN, KAREN M (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Affect;Antibiotics;Bacteria;Bacterial Infections;Behavior;Binding;Biochemical;Biological Assay;burden of illness;Cancer Etiology;Cancerous;Cessation of life;Chemoreceptors;Chemotaxis;Citrates;Collaborations;colonization resistance;Complement;Crystallization;Crystallography;Cues;Data;Disease;experimental study;extracellular;Frequencies;Fumarates;Gastrointestinal tract structure;gene product;Genes;Genetic Transcription;Gland;Growth;Health;Helicobacter Infections;Helicobacter pylori;host-microbe interactions;Immune;in vivo;Incidence;Individual;Infection;innovation;insight;Knowledge;Ligand Binding;Ligand Binding Domain;Ligands;malignant stomach neoplasm;Measures;Mediating;Metabolic;Metabolism;Methods;Microbe;Mission;Molecular Biology;Molecular Conformation;mouse model;Mucous Membrane;Mus;mutant;Nature;new therapeutic target;novel therapeutics;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Persons;Physiology;Play;Population;Population Control;Population Dynamics;pressure;prevent;Process;Proteins;Public Health;receptor;Regulon;Research;Resistance;Resolution;response;Role;Series;Shapes;Signal Transduction;Signaling Molecule;Stomach;Structural Biologist;Structure;Testing;Therapeutic;Tissues;Ulcer;United States;United States National Institutes of Health;Waste Products;Work

PROJECT_TITLE: The function of chemotactic signal transduction during colonization and disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative  Growing pre-clinical and clinical evidence indicate that fasting for several hours each day can reduce cancer risk, but the mechanisms by which fasting decreases cancer risk are not understood. We propose to use both animal models and human samples to test how daily fasting optimizes mitochondrial function to reduce cancer risk. Since nearly 40% of all men and women will be diagnosed with cancer at some point in their lives, and daily fasting is an easy lifestyle intervention that can be readily adopted by most individuals, the proposed research project is highly relevant to NCI’s mission to reduce the incidence of cancer.

PI_NAMEs: PANDA, SATCHIDANANDA  (contact)

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: 1 year old;Address;Adopted;Affect;Age;Age of Onset;age related;aged;Aging;aging population;aging related;Animal Feed;Animal Model;animal old age;Animals;anti-cancer;Biological Assay;Body Weight;Cancer Biology;cancer cell;Cancer Model;cancer prevention;cancer risk;cancer therapy;Cardiovascular Diseases;Cell Physiology;Cells;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Research;Clinical Trials;combinatorial;comparative;Consumption;Data;Development;Diagnosis;Disease;Distal;Eating;effective intervention;Effectiveness;effectiveness evaluation;Elderly;Energy consumption;Energy Intake;Energy Metabolism;Epidemiology;excessive weight gain;experimental study;Fasting;feeding;food consumption;Foundations;Functional disorder;Health;Health Benefit;Hour;Human;human old age (65+);improved;In Vitro;in vivo;Incidence;Individual;innovation;insight;Intermittent fasting;Intervention;Intervention Studies;juvenile animal;Knowledge;Length;lifestyle intervention;Liver;male;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;men;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Mission;Mitochondria;mitochondrial dysfunction;Mus;National Cancer Institute;neoplastic cell;Neurodegenerative Disorders;Normal Cell;Nutrient;nutrient metabolism;Obese Mice;Obesity;obesity prevention;obesogenic;old mice;Outcome;Physiological;Physiology;Plasma;Population;pre-clinical;prevent;Prevention strategy;Production;Protein Secretion;Publishing;Randomized, Controlled Trials;Regulation;Research;Research Project Grants;Respiration;response;Risk;Risk Factors;Risk Reduction;Rodent;Sampling;sex;Shotguns;skills;Solid;Structure;Testing;Therapeutic;Therapeutic Intervention;Time-restricted feeding;Tissues;Treatment outcome;treatment response;tumor;tumor growth;tumor progression;tumorigenic;western diet;Wild Type Mouse;Woman;Xenograft procedure

PROJECT_TITLE: Impact of Time-Restricted Feeding in Reducing Cancer Risk Through Optimizing Mitochondria Function


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Palliative Care;Physical Rehabilitation;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Heart failure is the leading cause of hospitalization among adults aged 65 years and older in the United States, and individuals in this population experience significant functional limitations, intense physical and psychological symptoms, and decreased quality of life. The objective of this proposal is to develop and test LiveWell-HF, a psychologically informed palliative rehabilitation model designed to simultaneously address the psychosocial and functional needs of older adults after heart failure hospitalization. Findings from this proposal will be used to optimize LiveWell-HF for a next phase randomized control trial to evaluate its impact on quality of life in this vulnerable population.

PI_NAMEs: KEENEY, TAMRA J (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Adoption;Adult;Advanced Malignant Neoplasm;age-related disease;American;Anxiety;Award;Awareness;Benchmarking;biopsychosocial;burden of illness;Cardiology;care delivery;care systems;career;career development;Caring;Chronic;Clinical;clinical trial implementation;Clinical Trials;Complex;coping;cost;Data;design;Development;disability;Disease;Distress;effective intervention;Effectiveness;efficacy trial;Elderly;Environment;evidence base;experience;Fatigue;Focus Groups;Fostering;functional decline;functional improvement;Future;General Hospitals;Goals;Health;health care service utilization;Healthcare;Heart failure;Home;Hospitalization;human old age (65+);Impairment;improved;improved outcome;Individual;Institution;International;Intervention;intervention delivery;intervention refinement;Interview;Leadership;leadership development;Life;Lived experience;Manuals;Massachusetts;medical schools;Mentors;Mentorship;Methods;model design;Modeling;mortality risk;multiple chronic conditions;New York Heart Association Class III/IV;novel;older adult;Outcome;Pain;palliative;Palliative Care;Pathway interactions;Patients;Personal Satisfaction;Phase;Physical Rehabilitation;physical symptom;Physical therapy;Physicians;Pilot Projects;Population;Positioning Attribute;prevent;primary outcome;prognostic;Program Acceptability;programs;Protocols documentation;Provider;psychologic;psychological symptom;Psychological Tests;psychosocial;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Research;Research Design;Research Methodology;Research Personnel;Research Training;Role;Scientist;Services;skills;Strategic Planning;Structure;Symptom Burden;symptomatic improvement;Testing;therapy development;Training;treatment as usual;Uncertainty;United States;United States National Institutes of Health;Value of Life;Vulnerable Populations;Work

PROJECT_TITLE: Enabling Older Adults to 'LiveWell' with Advanced Heart Failure: Development of a Palliative Rehabilitation Model

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative RELEVANCE TO PUBLIC HEALTH: This proposal contributes to improving reproductive health by focusing on a new ion channel complex and its modulation and how it may help keep the uterus relaxed during the progression of pregnancy. Understanding the expression and activity of this complex may contribute knowledge as to how the uterus becomes more contractile over the course of pregnancy. Knowledge gained from this proposal will help determine whether this complex modulates uterine function.

PI_NAMEs: ENGLAND, SARAH K. (contact);SANTI, CELIA M

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Address;Calcium;Calcium Channel;Cell Separation;Cells;Charge;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;Data;Dyes;Fetus;Flow Cytometry;Frequencies;Funding;Future;Goals;Human;human tissue;Image;improved;In Vitro;in vivo;Ion Channel;knock-down;Knowledge;Measures;member;Membrane;Membrane Potentials;Molecular;mRNA Expression;Mus;Myometrial;myometrium;novel;Oxytocin;patch clamp;Pathway interactions;Potassium;Potassium Channel;Pregnancy;Premature Labor;prevent;protein expression;Proteins;Proteomics;Public Health;Publishing;Regulation;Relaxation;Reporting;Reproductive Health;Role;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Sodium;Testing;Therapeutic;Time;uterine contractility;Uterus;voltage sensitive dye;Work

PROJECT_TITLE: A novel molecular mechanism for stimulating uterine contractility by oxytocin

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Public Health Relevance Statement  The CAV1 gene encodes the caveolin-1 protein which is associated with glaucoma, the second leading cause of blindness worldwide. The expression of caveolin-1 is also elevated in retinal inflammatory diseases such as diabetic retinopathy and autoimmune uveitis, but the function of caveolin-1 in the retina remains elusive. Understanding the function of this ocular disease-associated gene is likely to lead to novel therapeutic strategies for inflammatory eye disease.

PI_NAMEs: ELLIOTT, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;adenovirus mediated delivery;Adenoviruses;Anti-Inflammatory Agents;Antiinflammatory Effect;autoimmune uveitis;biological adaptation to stress;Blindness;Blood-Retinal Barrier;CAV1 gene;Caveolae;caveolin 1;Cell Line;cell type;Cells;chemokine;Complex;cytokine;Development;Diabetic Retinopathy;Disease;Dose;experimental study;Eye diseases;Functional disorder;Gene Transfer;Genes;genetic variant;Glaucoma;glial activation;Goals;Growth Factor;human disease;Immune;immune cell infiltrate;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;innovation;Link;Literature;Maintenance;Mediating;Membrane;Modeling;Morphology;Muller's cell;Nerve Crush;Nerve Degeneration;Neural Retina;Neuroglia;Neurons;new therapeutic target;novel;novel therapeutic intervention;Ocular Physiology;Optic Nerve;Organ;PC3 cell line;Pharmaceutical Preparations;Play;Primary Open Angle Glaucoma;prostate cancer cell line;protein expression;protein function;Proteins;public health relevance;Publishing;response;Retina;reverse genetics;Risk;Role;scaffold;side effect;Signal Transduction;Steroids;Stress;Structural Protein;System;Testing;therapeutic target;Tissues;Titrations;Virus

PROJECT_TITLE: Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Current sepsis treatment guidelines and quality measures recommend immediate administration of antibiotics to all patients with suspected sepsis, but there is growing recognition that respiratory viruses are a common cause of sepsis and that many patients with viral sepsis may suffer harm from unnecessary antibiotic treatment. The proposed research will describe the burden of viral sepsis in a nationally representative dataset, investigate current antibiotic prescribing patterns and associations with outcomes in this population, and evaluate whether antibiotics can be safely withheld in patients with viral sepsis and low procalcitonin levels. These objectives will have major clinical and public health impact by illuminating the magnitude of potential risk associated with current sepsis treatment guidelines, identifying opportunities for sepsis care improvement, and informing practical strategies to reduce unnecessary and prolonged use of antibiotics in patients with viral sepsis.

PI_NAMEs: SHAPPELL, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: WYATT, DERRICK

PROJECT_TITLE: Antibiotic Utilization Patterns and Impact on Outcomes for Patients with Respiratory Viral Sepsis

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Hearing Loss;Lung;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: The overall goal of this proposal is relevant to public health because it seeks to prevent permanent hearing loss by linking behavioral, physiological and pharmacodynamic data in patients taking ototoxic antibiotics. The project will evaluate methods to detect ototoxicity by using individualized estimates of drug exposures and novel, newly developed hearing assessment tools to detect and predict ototoxicity. The overall goal of this proposal is relevant to NIH’s goal to foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting human health.

PI_NAMEs: GARINIS, ANGELA ;HUNTER, LISA LEIGH (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adverse event;Affect;alertness;alternative treatment;Aminoglycoside Antibiotics;aminoglycoside-induced ototoxicity;Aminoglycosides;Antibiotic Therapy;Antibiotics;antimicrobial;Assessment tool;Auditory;auditory threshold shift;Bacterial Infections;Behavioral;behavioral response;Blood;Cellular Phone;Childhood;Clinical;Clinical Data;Clinical Trials;clinically relevant;cohort;Collaborations;Communication;Consumption;Creativeness;Critical Illness;Cystic Fibrosis;cystic fibrosis patients;Data;design;detection method;Diagnostic;Diagnostic tests;Digit structure;dosage;Dose;Drug Exposure;Drug Kinetics;early awareness;Early Diagnosis;Effectiveness;Follow-Up Studies;Fostering;Frequencies;Future;Genetic;Genetic Diseases;Genomics;Goals;Guidelines;Health;Hearing;hearing impairment;hearing preservation;Hearing Tests;high risk;High-Frequency Hearing Loss;Human;Improve Access;improved;Individual;Individual Differences;Infection;Inner Hair Cells;innovation;Internet;Knowledge;Labyrinth;Life;Link;Longitudinal, observational study;Lung infections;Measures;Methods;Modeling;Monitor;nephrotoxicity;neural;neural hearing loss;Noise;novel;Oregon;otoacoustic emission;ototoxicity;Outcome;Outcome Study;Outer Hair Cells;Patient Self-Report;Patients;Pediatric Hospitals;permanent hearing loss;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;Pharmacotherapy;Phenotype;Physicians;Physiological;Population;Predisposition;preservation;prevent;prevent hearing loss;Prevention;Prevention trial;programs;prospective;Protocols documentation;Public Health;Pure-Tone Audiometry;remote delivery;Reporting;Research;response;Risk;Risk Factors;risk prediction;Science;Sensorineural Hearing Loss;side effect;Speech;Synapses;Testing;Time;Time Factors;Tinnitus;Tissues;tool;Translating;United States National Institutes of Health;Universities;uptake;young adult

PROJECT_TITLE: Prevention of Ototoxicity with Effective Monitoring (POEM) Pharmacokinetic and Auditory Linkages

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Public Health Relevance Statement-Narrative: This program provides training to develop future leaders in cancer immunobiology research. As a catalyst for developing the next generation of principal investigators, this training program will impact directly on improving cancer treatment, decreasing costs, and most importantly, improving the lives of cancer patients, all of which are directly relevant to public health

PI_NAMEs: HALDAR, MALAY ;PEAR, WARREN S (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Immunobiology;Neoplastic Lymphocyte

PROJECT_TITLE: Immunobiology of Normal and Neoplastic Lymphocytes

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Fluoride accumulates highly in the pineal gland, which is responsible for producing melatonin, the hormone that regulates the sleep-wake cycle. The proposed research will examine whether childhood fluoride exposure is associated with sleep patterns and fatigue as mediated by melatonin rhythms. This research has the potential to advance our understanding of a modifiable potential risk factor for childhood sleep disturbances.

PI_NAMEs: MALIN, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Accelerometer;actigraphy;Adolescent;Adult;Age;appropriate dose;Archives;Biology;Biometry;Birth;Body part;bone;calcification;Calcium;career;Chemicals;Child;Childhood;Chronic;Cities;Clinical;Clinical Research;clinically relevant;cohort;cost effective;Data Reporting;Dental;dental agent;Dental caries;design;Developed Countries;Development;Disease;early childhood;Endocrine;Endocrine disruption;Endocrine Disruptors;Ensure;Environment;Environmental Exposure;Environmental Health;Epidemiology;epidemiology study;Equilibrium;evidence base;Exposure to;Faculty;Fatigue;fluorapatite;Fluorides;Funding;Goals;Growth;Health;Health Benefit;Histopathology;Hormones;Human;Hydroxide Ion;Hydroxyapatites;improved;innovation;interest;Knowledge acquisition;Life;life span;Maintenance;Measures;Mediating;Medical center;Melatonin;Mentors;Mexico;Modern 1601-history;National Research Council;Nervous System Disorder;neurodevelopment;Neurosecretory Systems;neurotoxic;New York;North America;novel;Obesity;Oral health;Pathology;Patient Self-Report;Phase;Physiological;Pineal gland;Play;Population;Positioning Attribute;Pregnancy;prevent;Preventive;Production;prospective;Psychologist;Public Health;public health priorities;Questionnaires;Recommendation;Regulation;Reporting;Research;Research Personnel;Resources;response;Risk Factors;risk minimization;Role;Saliva;saliva sample;Salivary;Science;Scientist;skill acquisition;skills;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;sleep pattern;sleep quality;sleep regulation;Sleep Wake Cycle;social stress;Solid;standard measure;Symptoms;System;tenure track;Time;Titrations;tool;Tooth structure;Toxic Environmental Substances;Toxicology;Training;Training Programs;Translating;urinary;Urine;Water;Water fluoridation;Work;Youth

PROJECT_TITLE: Early life fluoride exposure, neurodevelopment and childhood sleep patterns


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Neurosciences;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoarthritis (OA) is a chronically painful condition and a leading cause of global disability. OA is characterized by articular cartilage deterioration and other joint pathologies including meniscus/ligament damage, synovitis, bone spurs and joint pain. None of the currently approved treatments alter disease progression by slowing articular cartilage degradation and/or promoting joint regeneration. Phlpp1 and Phlpp2 are cellular enzymes that limit cell proliferation and matrix production and are overexpressed in OA cartilage. In this project, we explore the mechanisms of Phlpp1/2 action in osteoarthritic joints and determine how Phlpp inactivation modifies articular cartilage quantity and quality, as well as pain, after injury and during aging.

PI_NAMEs: WESTENDORF, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Age;Age Months;aggrecan;Aging;allodynia;Animal Model;Arthralgia;articular cartilage;Articulation;Atomic Force Microscopy;Behavior;Behavior Therapy;Biological Assay;Biomechanics;Bone Spur;burden of illness;Cartilage;cartilage degradation;cartilage regeneration;cartilage repair;Cell Proliferation;cell type;Cells;Chondrocytes;chronic painful condition;Compensation;Coupled;Data;Degenerative polyarthritis;Deterioration;Development;disability;Disease;Disease Progression;Economic Burden;Elasticity;Enzymes;Genes;Goals;Histology;Histopathology;Human;improved mobility;In Vitro;in vivo;inhibitor;Injury;innovation;insight;interest;Intra-Articular Injections;joint injury;Joints;Knock-out;Knockout Mice;ligament injury;Measures;Medial meniscus structure;Meniscus structure of joint;Messenger RNA;Mobility decline;Molecular;Motion;multidisciplinary;Mus;Natural regeneration;nerve supply;Neurites;neurofilament;Neuronal Plasticity;Neurons;Neurotransmitters;novel therapeutics;Operative Surgical Procedures;osteoarthritis pain;overexpression;Pain;pain behavior;pain relief;Painless;palliative;Pathogenesis;Pathologic;Pathology;Periosteum;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;preservation;prevent;Production;Proliferating;Property;regenerative;Reporter;Risk Factors;Role;Saline;small molecule inhibitor;subchondral bone;Surface;Synovial Membrane;Synovitis;Tamoxifen;Testing;Thick;tissue regeneration;tissue repair;Tissues;transcriptomics;Weight-Bearing state;Work

PROJECT_TITLE: Phlpp phosphatases in osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ORG_CITY: Aurora

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Subjects with type 1 diabetes (T1D) have high risk of fracture that cannot be explained by bone mineral density (BMD) alone. Therefore, it has been hypothesized that bone quality and its microenvironment, including bone marrow adiposity (BMA), should play an important role on bone fragility in T1D. However, little is known about bone quality and BMA in T1D. This study proposes to assess 24-month changes in bone microstructure at the distal radius and distal tibia, and in BMA at the proximal femur in subjects with long-standing T1D compared to age-, sex-, and body mass index-matched controls without diabetes. Improving our understanding of the associations of T1D with bone density, quality, BMA, and strength could lead to the development of novel therapeutics to slow down or prevent bone loss and microstructural deterioration, and ultimately prevent fractures in this vulnerable population.

PI_NAMEs: CARBALLIDO-GAMIO, JULIO  (contact);SHAH, VIRAL N

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adipose tissue;Adolescence;Adult;Advanced Glycosylation End Products;Age;Aging;Ancillary Study;Body mass index;bone;Bone Density;Bone Diseases;bone fragility;bone health;bone loss;Bone Marrow;bone mass;bone metabolism;bone quality;bone strength;Caring;Chemicals;Childhood;Chronic;Clinical;cohort;comparison control;cortical bone;Cross-Sectional Studies;Data;Deterioration;Development;Diabetes Mellitus;Distal;Dual-Energy X-Ray Absorptiometry;economic cost;Etiology;Fatty acid glycerol esters;Femur;Fracture;fracture risk;General Population;Geometry;Global Change;glycemic control;high risk;Hip region structure;human old age (65+);Hyperglycemia;Hypoglycemia;Image;Image Analysis;Impairment;improved;Incidence;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Laboratories;Life;Life Expectancy;Literature;Magnetic Resonance Imaging;mechanical properties;Medical;middle age;morphometry;novel therapeutics;Obesity;Osteoporosis;osteoporosis with pathological fracture;Parents;Patients;Peripheral;Persons;Phenotype;Play;prevent;Radial;Reporting;Resolution;Risk;Role;Sample Size;Seminal;sex;Site;Spatial Distribution;Structure;substantia spongiosa;Techniques;tibia;Vertebral column;Vulnerable Populations;Water;X-Ray Computed Tomography

PROJECT_TITLE: Bone Quality in Patients with Long-Standing Type 1 Diabetes


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The proposed studies are designed to gain a detailed understanding of the critical role of amelogenin phosphorylation in the regulation of enamel mineral formation in vivo, using novel mouse models and advanced characterization techniques. The successful completion of this work will provide new insights into how hard tissues like bones and teeth form and aid in our understanding of inherited enamel diseases and factors that, for example, influence dental caries susceptibility. The successful completion of this work will also provide new insights for the development of improved methods for the regeneration of tooth enamel.

PI_NAMEs: BENIASH, ELIA  (contact);MARGOLIS, HENRY C

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acidity;Affect;Alanine;ameloblastin;Ameloblasts;Amelogenesis;amelogenin;Amino Acids;Area;Autophagocytosis;Biochemical;biomineralization;bone;Cell Death;Cell Physiology;Cells;Cellular biology;Crystal Formation;Defect;Dental caries;Dental Caries Susceptibility;Dental Enamel;Deposition;design;Development;Disease;driving force;electron diffraction;Electron Microscopy;electron tomography;Enamel Formation;enamel matrix proteins;enamelin;endoplasmic reticulum stress;Exhibits;Extracellular Matrix Proteins;fascinate;Goals;Growth;Heterozygote;High Prevalence;improved;In Vitro;in vivo;Incisor;Inherited;insight;Knock-in;Knock-in Mouse;Laboratories;Length;Mass Spectrum Analysis;Methods;mineralization;Minerals;Molecular Biology;mosaic;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Nature;novel;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Phosphorylation;photoemission;Play;Predisposition;prevent;Process;Proteins;Recombinant Proteins;Regulation;Resolution;Rod;Role;Serine;Site;Stress;Structure;Surface;Techniques;Testing;Time;Tissues;Tooth regeneration;Tooth structure;trafficking;transcriptome;transcriptome sequencing;Transmission Electron Microscopy;Variant;Work

PROJECT_TITLE: Essential role of amelogenin phosphorylation in tooth enamel formation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Complementary and Integrative Health;Mental Health;Neurosciences;Prevention

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Mindfulness meditation programs have been shown to effectively reduce stress. However, the brain mechanisms for these stress reduction benefits are as yet unclear. The broad objective of this project is to test whether a mindfulness training program leads to stress reduction (self-report and neural stress responding) via changes in white matter connections in the brain.

PI_NAMEs: DUTCHER, JANINE MICHELE (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: active control;Affect;Amygdaloid structure;Behavior;Behavior Therapy;Behavioral Mechanisms;Brain;brain based;Brain Mapping;Brain region;burnout;career;Cellular Phone;Collaborations;comparison control;conditioned fear;Cross-Sectional Studies;Data;Data Set;Diffusion;Diffusion Magnetic Resonance Imaging;Doctor of Philosophy;emotional stimulus;Employee;Environment;expectation;experience;experimental study;Faculty;Fostering;Functional Magnetic Resonance Imaging;Goals;Grant;Health;Health Benefit;Health Psychology;Imaging technology;Inflammation;interest;Intervention;Learning;Link;Literature;Maps;Measures;Mediating;Mentors;Methods;mindfulness;mindfulness intervention;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;Modeling;multimodality;National Center for Complementary and Integrative Health;neural;neuroimaging;neuromechanism;Neuronal Plasticity;Neurosciences;Nucleic Acid Regulatory Sequences;Outcome;Pathway interactions;Patient Self-Report;perceived stress;Persons;Physiological;Population;post intervention;Problem Solving;programs;Psychology;Randomized, Controlled Trials;Regulation;Regulatory Pathway;Research;Research Design;Research Personnel;Resources;response;Rewards;Risk Reduction;Sampling;Scanning;skills;smartphone application;social;Social Psychology;spectrograph;statistical learning;Stimulus;Stress;stress reactivity;stress reduction;Structure;Techniques;Testing;Training;Training Programs;Universities;white matter;Work;Writing

PROJECT_TITLE: White Matter and Stress Reduction Effects of Mindfulness Training


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE – Nationwide Children’s Hospital This project is relevant to public health because, as one of the nation’s largest children’s hospitals, Nationwide  Children’s Hospital has the patient population, research infrastructure, and investigator expertise to contribute  fundamentally to our understanding the pathophysiology and treatment of pediatric critical illness. In particular,  we expect the “Personalized Immunomodulation in Sepsis-Induced MODS” study to improve the survival of  children with sepsis-induced MODS and to improve their functional status and quality of life.

PI_NAMEs: HALL, MARK W (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;African American;anakinra;Ancillary Study;Anti-Inflammatory Agents;Aptitude;Beds;Belief;Biological;Biological Markers;Caring;Catchment Area;Caucasians;Censuses;Child;Child Care;Childhood;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;design;Development;Diagnostic Reagent Kits;Double-Blind Method;Enrollment;expectation;experience;Faculty;Functional disorder;functional status;Funding;Generations;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;health related quality of life;Hispanic;Immune;immune function;Immune response;Immunologic Adjuvants;Immunologic Monitoring;Immunologic Surveillance;Immunologic Tests;Immunologics;Immunophenotyping;immunoregulation;Immunosuppression;improved;In Situ;Individual;Inflammation;Infrastructure;innovation;Inpatients;Institution;Intervention;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Leadership;Medicine;meetings;member;Mentors;Mentorship;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;Nurses;Ohio;patient oriented;patient population;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Performance;Pharmaceutical Preparations;Pharmacy facility;Phenotype;Placebos;Population;primary outcome;Procedures;prospective test;Protocols documentation;Public Health;Quality of life;Randomized;randomized placebo-controlled clinical trial;Recording of previous events;Recovery;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;restoration;Role;safety and feasibility;Scientist;secondary outcome;Sepsis;Site;Standardization;Steel;systemic inflammatory response;Talents;Time;tocilizumab;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Nutrition;Obesity;Physical Activity;Prevention

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Despite advances in screening and identification of modifiable risk factors, the incidence and mortality of colorectal cancer (CRC) remains high, as does the incidence of obesity, which is a well-established risk factor for CRC. Lack of understanding of the biological pathways linking obesity and associated risk factors to CRC is a major limiting factor in the development of new strategies for CRC prevention. If successful, our project will identify novel pathways for CRC prevention and will establish methods for integrating metabolomic and other biomarker data and dimension-reduction approaches to identify pathways underlying risk factors for cancer and other chronic diseases.

PI_NAMEs: BEVER, ALAINA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Academic Medical Centers;adipokines;adiponectin;Biological;Biological Markers;Biostatistical Methods;Body mass index;Branched-Chain Amino Acids;C-Peptide;C-reactive protein;cancer epidemiology;Cancer Etiology;career;Cessation of life;Characteristics;Chronic Disease;Clinical;clinical epidemiology;Clinical Nutrition;clinical training;cohort;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Consumption;Coupled;Dana-Farber Cancer Institute;Data;data integration;data reduction;design;Development;Diet;dietary;Dietary Factors;Dietary Intervention;Dietary Practices;dimension reduction;Doctor of Philosophy;early onset colorectal cancer;Elasticity;energy balance;Environment;Epidemiologic Methods;Epidemiologist;Epidemiology;experience;Follow-Up Studies;Food;FRAP1 gene;Frequencies;gastrointestinal;General Hospitals;Genetic;Goals;Health;Health Professional;Health Sciences;high body mass index;Human;Incidence;Inflammation;Inflammatory;Insulin Resistance;Interleukin-6;Intervention;Knowledge;lifestyle factors;lifestyle intervention;Link;Malignant Neoplasms;Massachusetts;Mediating;Mediation;Mediator;medical schools;Medicine;meetings;member;men;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Methods;mid-career faculty;Modeling;modifiable risk;mortality;neoplastic;novel;novel marker;novel strategies;Nurses' Health Study;nutrition;Obesity;Oncologist;Oxidative Stress;Pathogenesis;Pathway interactions;Pattern;Physical activity;physical inactivity;Physicians;Plasma;population health;Population Sciences;pre-doctoral;Principal Component Analysis;Processed Meats;professor;programs;Proliferating;Prospective Studies;Public Health Schools;Questionnaires;Receptors, Tumor Necrosis Factor, Type II;Research;Research Personnel;Risk Factors;risk prediction;Role;Sampling;screening;Signal Pathway;Statistical Methods;Students;symposium;Testing;TNF gene;TNFRSF1B gene;Training;tumor;Tumor Necrosis Factor Receptor;Tumor Promoters;Unhealthy Diet;Variant;waist circumference;Woman

PROJECT_TITLE: Metabolomic signatures of inflammation and metabolic health in relation to colorectal cancer risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)L]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Columbus

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Heart diseases including heart rhythm disorders, in part due to abnormal sodium and calcium cycling in the heart, remain leading causes of morbidity and mortality in the US. This proposal seeks to gain new insights into how regulation of sodium channels inside the heart muscle cells regulates calcium cycling in normal and the diseased hearts. Information gleaned from these studies will be used to develop new therapeutic approaches to treat heart rhythm disorders.

PI_NAMEs: RADWANSKI, PRZEMYSLAW  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Affinity;Animals;Anti-Arrhythmia Agents;Arrhythmia;Binding;Biochemical;Biological Assay;Calcium;Calmodulin;Cardiac;Cardiac Myocytes;Data;Disease;Electrophysiology (science);Exhibits;Functional disorder;gain of function;Glean;Heart;Heart Diseases;heart rhythm;Image;Impairment;In Vitro;in vivo;insight;Laboratories;Link;Mediating;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Neurons;novel;novel strategies;novel therapeutic intervention;Phenotype;prevent;Protein Isoforms;Proteins;Regulation;Research;Role;RyR2;SCN8A gene;Secondary to;Sodium;Sodium Channel;stem;sudden cardiac death;Techniques;Testing;Transgenic Mice;Translating;United States;Variant;Viral

PROJECT_TITLE: Regulation and dysregulation of sodium channels by by calmodulin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project aims to achieve understanding of mechanisms underlying sepsis-induced ARDS due to Pseudomonas aeruginosa (PA) bacteremia. The novel premise is that PA causes endothelial pore formation, therefore endothelial barrier failure. The goals are to achieve new mechanistic understanding of these processes, and to evaluate pore-inhibiting strategies as possible cures for ARDS.

PI_NAMEs: BHATTACHARYA, JAHAR  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: acronyms;Actins;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Alveolar Macrophages;Bacteremia;Bacteria;Blood-Borne Pathogens;Calcineurin;CASP1 gene;Caspase;Cell membrane;Cells;Confocal Microscopy;Cytosol;Dimensions;Disease;Dose;effective therapy;Endothelial Cells;Endothelium;Enhancers;Event;F-Actin;Failure;Flagella;Gap Junctions;genetic manipulation;Goals;Inflammasome;Inhalation;Injections;intraperitoneal;Intravenous;Knowledge;Lung;lung injury;Membrane;Modeling;Molecular;mortality;Mus;N-terminal;neutrophil;novel;opportunistic pathogen;Pathogenesis;Pathology;Peritonitis;Permeability;Phase;Process;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Inflammation;repaired;Research;response;Role;Sepsis;sepsis induced ARDS;septic;Severities;sex as a biological variable;System;Systemic infection;Tail;Text;Therapeutic;Time;Transfection;Veins

PROJECT_TITLE: Mechanistic role of membrane pore formation in lung-endothelial barrier failure due to blood-borne pathogens.

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Infertility;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE This project focuses upon the kisspeptin-neurokininB-dynorphin (KNDy) hypothalamic circuitry in monkeys and man. The contributions of various components of the KNDy system to normal reproductive development and function will be explored using receptor agonists and antagonists. Exogenous pulsatile kisspeptin and opioid receptor antagonists will be assessed as a potential treatment tools for patients with certain types of hypogonadal disorders.

PI_NAMEs: SEMINARA, STEPHANIE BETH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adolescent;Adult;Agonist;antagonist;Architecture;biobank;Biological Assay;clinical phenotype;Collaborations;Complement;curative treatments;Defect;Disease;Dose;Dynorphins;Evaluation;experience;Functional disorder;Genetic;genome-wide analysis;GNRH1 gene;Goals;Gonadal Steroid Hormones;Grant;healthy volunteer;Human;Human Genetics;Hypogonadotropism;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;improved;in vivo;insight;interdisciplinary collaboration;Kallmann Syndrome;KISS1 gene;Klinefelter's Syndrome;Liquid substance;loss of function mutation;Macaca mulatta;man;Monkeys;neuroendocrine phenotype;Neurokinin B;Neurons;Neuropeptides;novel;novel therapeutics;Opioid;Opioid Antagonist;Participant;Pathway interactions;patient oriented research;Patients;Peptides;Pharmacology;Physiologic pulse;Physiological;Physiology;Play;Positioning Attribute;prepuberty;Primates;Puberty;rapid growth;receptor;repository;reproductive;reproductive development;Reproductive Endocrinology;reproductive function;reproductive system disorder;Research Personnel;Resistance;restraint;Sex Characteristics;Sexual Maturation;Signal Pathway;Signal Transduction;System;tool;Translating

PROJECT_TITLE: Towards Curative Therapies for Hypogonadotropic Diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Nutrition;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE This project seeks to test the feasibility and acceptability of a peer support intervention to lower blood pressure among Black adolescents with high blood pressure in the rural South. The objective of this career development award is to nurture the development of Shakia Hardy, PhD, MPH into an independent researcher focused on the development and implementation of effective interventions to increase equity in cardiovascular health in early life.

PI_NAMEs: HARDY, SHAKIA TRANECE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 17 year old;Academic skills;Academy;Acceleration;acceptability and feasibility;Active Learning;Address;Adherence;Adolescence;Adolescent;Adoption;Adult;Affect;Alabama;American;Behavior;behavior change;behavior change wheel;Black race;Blood Pressure;blood pressure elevation;blood pressure reduction;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career development;Childhood;Church;Clinic;Clinical;Cluster randomized trial;Communities;community partners;contextual factors;copayment;Counseling;DASH diet;Data;design;Development;Diastolic blood pressure;didactic education;dietary;Dietary Practices;Doctor of Philosophy;Education;Educational Curriculum;effective intervention;effectiveness testing;effectiveness trial;Epidemiology;Equity;Evaluation;experience;Face;feasibility testing;Feedback;Focus Groups;Food;Funding;future implementation;Goals;Grant;Guidelines;Health behavior;health care availability;Health education;health equity;Healthy Eating;healthy lifestyle;High Prevalence;Hypertension;implementation intervention;implementation science;improved;Individual;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Lead;Leadership;Life;Life Style;Life Style Modification;Medicine;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;North Carolina;Obesity;Parents;Participant;patient-clinician communication;Pediatrics;peer;peer support;Persons;Physical activity;Pilot Projects;pilot test;Population Sciences;Positioning Attribute;preempt;Preventive Medicine;Principal Investigator;Process Measure;professor;programs;Protocols documentation;Publishing;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reduce health disparities;Research;research and development;Research Personnel;Rural;Rural Community;rural environment;rural residence;satisfaction;Scientist;Self Efficacy;Self Management;Site;skills;social epidemiology;social health determinants;Structure;success;Surveys;tenure track;Testing;theories;therapy development;Training;Travel;Universities;uptake

PROJECT_TITLE: Peer Support for Lowering Blood Pressure among Adolescents: A Pilot, Randomized Controlled Trial


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is a lethal disease. There is an urgent need to develop precision tools for improved staging and development of personalized therapy approaches. The goal of our academic-industrial partnership (AIP) - Mayo Clinic and Sofie Biosciences - is to execute a coherent strategy for the potential FDA approval and clinical translation of a novel imaging technique, 68Ga-FAP-inhibitor (FAPI)-46 PET, which can address the unmet clinical needs in pancreatic cancer as well as improve our understanding of the biology of the disease.

PI_NAMEs: GOENKA, AJIT HARISHKUMAR (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Address;Affinity;Binding;Biological Assay;Biological Markers;Biological Sciences;Biology;Blood;CA-19-9 Antigen;Cancer Etiology;cancer imaging;carcinogenesis;Cessation of life;Characteristics;Chelating Agents;Chemistry;Clinic;Clinical;clinical development;clinical imaging;clinical investigation;clinical practice;clinical translation;Communities;Comparative Study;contrast imaging;cost;Coupled;Data;Desmoplastic;Detection;detection sensitivity;Development;Development Plans;Diagnostic;Disease;Drug Kinetics;Evaluation;Excision;expectation;fibroblast-activating factor;Fibroblasts;Fibrosis;flexibility;fluorodeoxyglucose positron emission tomography;follow-up;Funding;Funding Mechanisms;Futility;Gallium;Goals;Image;imaging properties;Imaging Techniques;Immune;Immunophenotyping;improved;in vivo;industry partner;Infrastructure;inhibitor;innovation;insight;instrumentation;Investigation;Knowledge;KRAS2 gene;Lead;Lesion;Licensing;liquid biopsy;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Medical;meetings;Membrane;Metabolic;Methodology;Modeling;molecular imaging;Molecular Target;Morbidity - disease rate;mortality;multidisciplinary;nanomolar;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;novel imaging technique;novel marker;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;outcome prediction;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Peptide Hydrolases;personalized medicine;Physiological;Play;Positioning Attribute;Positron-Emission Tomography;Prognosis;prognostic;Property;prospective;protein expression;Provider;Quinolones;Radiation therapy;Radioactivity;radiologist;radiotracer;Reader;Recurrence;Reference Standards;Regulatory Pathway;Resectable;Resources;response;Risk Reduction;Role;Sensitivity and Specificity;Specimen;Staging;Surgical Models;targeted imaging;Techniques;Technology;Testing;theranostics;Therapeutic;therapy resistant;Tissue Sample;tool;Toxic effect;Translating;translational barrier;Translations;tumor;tumor DNA;tumor growth;tumor microenvironment;uptake;Validation

PROJECT_TITLE: Quantitative In Vivo 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 PET Imaging of Cancer-Associated Fibroblasts (CAFs) in Pancreatic Ductal Adenocarcinoma (PDA)


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The Pathways in Biological Sciences (PiBS) program trains a select group of PhD students to prepare them for their future careers while they conduct their graduate research on the most pressing problems in modern biology. PiBS ensures the acquisition of critical scientific, leadership, and communication skills, while instilling a strong and proactive sense of inclusion and diversity. PiBS trainees will benefit society through their career- long contributions to a variety of biological endeavors, including research, industry, education, communication, and policy.

PI_NAMEs: DAUGHERTY, MATTHEW ;HAMPTON, RANDOLPH Y. (contact);PASQUINELLI, AMY E.

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biological Sciences;Pathway interactions;Training Programs

PROJECT_TITLE: Pathways in Biological Sciences Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative The glucose-lowering effect of metformin and the underlying mechanisms have been extensively studied, but the effect of metformin on hepatic lipid metabolism and the action site of metformin warrant further research. To fill in the knowledge gap, we will perform liquid chromatography-high resolution mass spectrometry-based lipidomics, metabolomics, and 13C isotope tracing analysis, employ synthetic metformin probe and intestinal AMPK alpha 1 knockout mice, to quantitatively characterize the connections between metformin-induced metabolic alterations in intestine and hepatic lipid metabolism and to identify molecular targets of metformin. The findings of this study will unravel the role of metformin actions in intestine in modulating hepatic lipid metabolism and provide significant insights into strategies to prevent or treat dietary-induced fatty liver diseases.

PI_NAMEs: LIU, XIAOJING  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Affect;Alkynes;Attenuated;Communication;Coupled;Data;dietary;Disease;Epithelial Cells;fatty acid oxidation;Fatty Liver;fatty liver disease;Fructose;Gene Modified;Glucose;Goals;Hepatic;High Prevalence;in vivo;insight;intestinal epithelium;Intestines;Isotopes;Knockout Mice;Knowledge;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Liquid Chromatography;Liver;Liver diseases;mass spectrometer;Mass Spectrum Analysis;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Metformin;Methods;Molecular Target;Mus;Nature;non-alcoholic fatty liver disease;Organ;Patients;Pharmaceutical Preparations;Pilot Projects;pleiotropism;prevent;Reporting;Research;Resolution;Role;Site;Small Intestines;sugar;Testing;Tissues

PROJECT_TITLE: Investigating the involvement of small intestine in metformin's effect on hepatic lipid metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Effective antiretroviral therapy is critical during pregnancy for women living with HIV (WLHIV) for the health of both the mother and the fetus, but there are knowledge gaps in pharmacology of new HIV drugs, ways to assess adherence, and safety in pregnancy that prevent efficient and effective deployment of our most promising new HIV drugs in pregnant women. The objective of this proposal is to advance our knowledge of the pharmacology and safety of several new HIV drugs -- tenofovir alafenamide (TAF), bictegravir, and doravirine--in pregnant and post-partum women, using innovative tools, such as pharmacometrics and physiologically based pharmacokinetic (PBPK) modeling. Research goals include describing TAF pharmacokinetics (PK) and adherence benchmarks in pregnancy, characterizing the risk and implications of TAF-associated metabolic syndrome in pregnant WLHIV, and predicting bictegravir and doravirine PK in pregnant women and their fetuses, with the overall goal of optimizing HIV therapeutics for pregnant WLHIV.

PI_NAMEs: EKE, AHIZECHUKWU C. (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Adherence;Adult;Adverse effects;analytical method;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;Baltimore;Benchmarking;Biometry;Blood;Blood Glucose;career;career development;Child;Clinical Pharmacology;Clinical Trials Network;cohort;Cohort Studies;Collaborations;Cytochrome P450;Data;Data Analyses;Databases;Decision Making;Development;Development Plans;Diphosphates;Dose;Drug Kinetics;Drug Modelings;Drug or chemical Tissue Distribution;Drug usage;Dryness;Enrollment;Environment;Enzymes;Exposure to;FDA approved;fetal;fetal drug exposure;Fetus;Fumarates;Funding;Future;Gestational Diabetes;Glucuronosyltransferase;Goals;Hair;Health;High Density Lipoproteins;HIV;Hospitals;Hypertension;improved;in silico;In Vitro;in vivo;innovation;Institution;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;Knowledge;Lead;Logistic Regressions;Maryland;Maternal-fetal medicine;Measures;medication compliance;medication safety;member;Mentors;Mentorship;Metabolic;Metabolic syndrome;Modeling;Modification;Mothers;novel;Participant;Perinatal Epidemiology;perinatal HIV;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacokinetic model;Pharmacology;pharmacometrics;Pharmacotherapy;Phase;Physicians;physiologically based pharmacokinetics;Physiology;Placenta;Plasma;Population;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Trimesters;Pregnant Women;Premature Birth;prevent;Prevention;Prodrugs;prospective;Prospective, cohort study;Publications;PubMed;Research;Research Design;Research Personnel;Risk;Safety;safety assessment;Scientist;Second Pregnancy Trimester;secondary analysis;Serum;skills;Special Population;Spottings;Syndrome;Techniques;Tenofovir;Testing;Therapeutic;Third Pregnancy Trimester;tool;Training;transmission process;Triglycerides;UGT1A1 gene;United States National Institutes of Health;Universities;Uridine Diphosphate;viral resistance;waist circumference;Weight Gain;Woman;Women's Health;Work

PROJECT_TITLE: Understanding Medication Adherence Benchmarks, Safety and Pharmacometrics of Novel Antiretrovirals in Pregnant Women Living with HIV.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: NARRATIVE – OVERALL The overall goal of this Developmental and Hyperactive Ras Tumor (DHART) SPORE is to implement effective targeted therapies for neoplasms and cancers characterized by mutations in the NF1 tumor suppressor gene (TSG) by conducting integrated, mechanistically based translational research. Using novel genetically engineered mice, patient derived xenografts, and robust Omics, we will delineate mutations that contribute to cancer pathogenesis and uncover new biomarkers of drug response and resistance that will inform the development of “next generation” treatments.

PI_NAMEs: CLAPP, DAVID W (contact);SHANNON, KEVIN M.

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Acceleration;acquired drug resistance;Acute Myelocytic Leukemia;Address;Adolescent and Young Adult;Affect;Alleles;Benefits and Risks;Benign;Binding;Biological;Biological Markers;Cancer Biology;cancer initiation;cancer predisposition;cancer therapy;Cell Lineage;Central Nervous System Neoplasms;Child;Childhood;Clinical;Clinical Investigator;Clinical Trials;comparative;Core Facility;Development;developmental disease;Disease;driver mutation;drug response prediction;Funding;Genetic;Genetically Engineered Mouse;genome-wide;Germ Lines;Glioblastoma;Goals;GTPase-Activating Proteins;Guanine Nucleotides;Guanosine Triphosphate;Hematopoietic Neoplasms;High Prevalence;Human;Hydrolysis;hyperactive Ras;improved outcome;Incidence;Inherited;Juvenile Myelomonocytic Leukemia;Learning Disabilities;Lung Adenocarcinoma;Malignant Neoplasms;Medical;MEK inhibition;Melanoma;member;Molecular;Molecular Analysis;molecular targeted therapies;Morbidity - disease rate;mortality;Mutation;neoplastic;Neurofibromatosis 1;Neurofibrosarcoma;next generation;NF1 gene;novel;novel therapeutic intervention;novel therapeutics;Organ;Orphan;Output;Pathogenesis;Pathway interactions;patient derived xenograft model;patient oriented;Patients;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Physicians;Plexiform Neurofibroma;Population;Pre-Clinical Model;preclinical trial;predictive marker;Predisposition;premalignant;Premature Mortality;Prevention;Prognostic Marker;programs;protein function;Publications;rare cancer;ras GTPase-Activating Proteins;Research Personnel;Resistance;response;Risk;risk stratification;Role;Sampling;Sarcoma;Scientist;Signal Transduction;skeletal dysplasia;skin lesion;Skin Pigmentation;Syndrome;System;targeted treatment;Therapeutic;Therapeutic Studies;Tissues;translational cancer research;Translational Research;translational scientist;translational therapeutics;treatment response;tumor;Tumor Suppressor Genes;Work


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD);Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE – ADMINISTRATIVE CORE (CORE A) The DHART SPORE currently encompasses three highly integrated projects and three cores with the goal of implementing effective targeted molecular therapies for neoplasms and cancers characterized by NF1 mutations by conducting integrated, mechanistically based translational research. The goal of the Administrative Core is to provide scientific and administrative oversight for all the program components of the DHART SPORE. The core will provide the overall organizational framework by which researchers communicate and interact, manage finances, coordinate the review of progress of the research projects, scientific cores and developmental programs (DRP & CEP), consult with the members of the External and Internal Advisory boards, coordinate the overall data integration and analysis of the DHART SPORE, and continue to refine our infrastructure to enable sharing of data generated by our studies with other internal and external NF-collaborative consortiums.

PI_NAMEs: CLAPP, DAVID W (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Advisory Committees;Area;authority;Basic Science;California;Cancer Center;Cancer Patient;career;Catchment Area;Child;Clinical Trials;Cloud Computing;Collaborations;Communication;Communities;computing resources;Consult;Consultations;Data;Data Analyses;Data Commons;data integration;data management;data sharing;data visualization;Databases;Decision Making;Development;driver mutation;Educational workshop;Ensure;Environment;Evaluation;Funding;Goals;hyperactive Ras;Indiana;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;meetings;member;Memorial Sloan-Kettering Cancer Center;Metadata;molecular targeted therapies;National Cancer Institute;NF1 gene;NF1 mutation;novel;novel therapeutics;Office of Administrative Management;Organization administrative structures;Orphan;Participant;Pathology;Patient Care;patient population;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Pennsylvania;Performance;Philadelphia;preclinical trial;Preparation;Process;Productivity;programs;Progress Reports;public-private partnership;Publications;Rare Diseases;Regulation;Reporting;Reproducibility;Reproduction spores;Research;Research Personnel;Research Project Grants;Resources;San Francisco;Science;Services;Signal Transduction;Site;Strategic vision;Structure;Supercomputing;Synapses;Texas;timeline;tool;Translational Research;translational research program;Travel;tumor;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Synthetic oxytocin infusion, the current standard clinical method used to induce labor, has important shortcomings. Breast nipple stimulation triggers the pulsatile release of endogenous oxytocin hormone in the brain to induce spontaneous contractions, stimulates lactogenesis, and has other physiological benefits. Therefore, the current proposal seeks to examine whether inpatient nipple stimulation therapy via electric breast pump during labor induction results in a greater likelihood of spontaneous vaginal delivery, improves the frequency of exclusive and sustained lactation postpartum, and is more cost-effective than synthetic oxytocin infusion without nipple stimulation among nulliparas.

PI_NAMEs: SON, MOEUN  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: acceptability and feasibility;Birth;blood-brain barrier penetration;Body Weight decreased;Brain;Breast;Breast Feeding;breast pump;care costs;Childbirth;Clinical;Colostrum;comparison group;Conduct Clinical Trials;Continuous Infusion;Continuous Intravenous Infusion;cost;Cost Analysis;cost effective;cost effectiveness;Costs and Benefits;Data;Developing Countries;Devices;Discipline of obstetrics;Dose;Down-Regulation;experience;feeding;Frequencies;Health Benefit;Health Care Costs;health related quality of life;Hormones;Hospitals;Human Milk;Hydration status;improved;Induced Labor;Infant;Infant Care;Infant Health;infant nutrition;Infusion procedures;Inpatients;Intervention;intrapartum;Intravenous infusion procedures;Investigation;Lactation;lactogenesis;Life;Maternal Health;Medical;Methods;Milk Ejection;milk expression;milk supply;Molecular;Mothers;Multicenter Trials;Muscle;Myometrial;National Institute of Child Health and Human Development;Newborn Infant;Nipples;novel;Nulliparity;nutrition;obstetrical complication;Outcome;Oxytocin;Oxytocin Receptor;Patient Participation;Perception;Physiological;Pilot Projects;Posterior Pituitary Gland;Postpartum Period;Poverty Areas;pregnant;premature;Production;Public Health;Publishing;Randomized;randomized trial;randomized, clinical trials;Recommendation;Reflex action;Resources;Risk;Safety;Severities;Source;success;suckling;Testing;therapeutically effective;Time;trend;United States;Universities;Uterine Contraction;Vaginal delivery procedure;Woman;Work

PROJECT_TITLE: STIM: Stimulation Therapy to induce Mothers: a Multicenter Trial


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE – OMICS CORE NF1 malignancies have high morbidity and mortality with no clear effective therapies. The Omics Core will provide essential state-of-the-art next-generation sequencing, kinome activity assessments and informatics infrastructure to allow Projects 1-3 to determine and define new therapeutic treatments for NF1 malignancies.

PI_NAMEs: LIU, YUNLONG  (contact)

PROJECT_TERMS: Address;autosome;Bioinformatics;Biological;Biology;Cell Proliferation;Cell Survival;Chemicals;Collaborations;Computational Biology;Consultations;Data;Data Analyses;data and analysis portal;data exchange;data integration;data management;Data Set;design;Development;Disease;effective therapy;exome sequencing;experimental study;FRAP1 gene;functional loss;Funding;Gene Expression;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Genome;Genomics;Genotype;Goals;Group Meetings;Human;hyperactive Ras;Informatics;informatics infrastructure;inhibitor;Institution;Knowledge;Laboratories;loss of function;Malignant Neoplasms;Medical center;MEKs;Methodology;Methods;Modeling;Molecular;Molecular Analysis;Molecular Profiling;molecular targeted therapies;Morbidity - disease rate;mortality;Multiomic Data;Mus;Mutation;Mutation Spectra;Neoplasms;neurofibroma;Neurofibromatosis 1;next generation sequencing;NF1 gene;novel;novel therapeutics;Pathology;Pathway Analysis;Pathway interactions;patient derived xenograft model;Performance;Phosphotransferases;PIK3CG gene;Process;Proteomics;Proto-Oncogene Proteins c-akt;ras GTPase-Activating Proteins;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;response;response biomarker;Sampling;Services;Signal Pathway;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Specimen;Synapses;System;targeted exome sequencing;targeted treatment;Technology;Therapeutic;therapeutic candidate;therapeutic target;therapy resistant;transcriptome;transcriptome sequencing;treatment response;tumor;tumor initiation;tumor progression;web portal;working group

PROJECT_TITLE: Omics Core