ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer’s disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization. If our randomized controlled trial (RCT) is successful, the GDA intervention could be an efficacious, accessible, and scalable approach to reduce the burden of SCD, slow cognitive decline, and improve quality of life (QoL) in older ICU survivors.

PI_NAMEs: KHAN, BABAR A (contact);STEWART, JESSE C;WANG, SOPHIA

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: 2 arm randomized control trial;active control;Address;Admission activity;Adult;Adverse effects;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;anti-depressive agents;Black race;Chronic;Clinical;Cognitive;cognitive change;cognitive function;Cognitive Therapy;cohort;cost;Critical Care;Critical Illness;Data;dementia risk;depressive symptoms;design;Drug Interactions;Education;efficacy testing;Enrollment;Ethnic Population;evidence base;experience;functional disability;geriatric depression;Geriatric Psychiatry;Health;Health Psychology;high risk population;Hispanic;Hospitalization;Impaired cognition;improved;Incidence;indexing;Indiana;Individual;Infrastructure;Intensive Care Units;Internet;Intervention;Knowledge;Latino;Latinx;Letters;Link;Measures;Mediating;Medical;Medicine;Memory;Mental Depression;multiple chronic conditions;Neuropsychology;novel;older adult;Outcome;Outcome Study;Participant;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Population Heterogeneity;prevent;Psychology;Psychotherapy;Public Health;Quality of life;Questionnaires;racial population;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Risk;Risk Reduction;SF-36;Survivors;survivorship;Testing;Therapeutic Intervention;therapy design;Thinking;Trail Making Test;Underserved Population;Universities;web platform

PROJECT_TITLE: ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: TW

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: DAR ES SALAAM

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS

PHR: PROJECT NARRATIVE HIV and drug use stigma are a barrier to HIV prevention, care and treatment services access among people who use drugs. Although a family is critical to support people who use drugs to enter and remain in HIV and drug prevention and treatment, globally there are no interventions to address HIV and drug use stigma that people who use drugs face from their family members. This study will address this gap by adapting existing evidence-based health facility HIV and drug use stigma reduction interventions and create a stigma-reduction intervention for family members of people who use drugs that will address both HIV and drug use stigma coming from family members going towards people who use drugs.

PI_NAMEs: MLUNDE, LINDA BEATRICE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;aged;AIDS prevention;antiretroviral therapy;Businesses;Capital;care systems;Caring;Client;Clinic;Community Healthcare;community organizations;Data;design;Development;Disease;Drug usage;Drug user;Educational Curriculum;Enrollment;evidence base;Evidence based intervention;experience;Face;Factor Analysis;Family;Family member;family support;Feedback;Focus Groups;formative assessment;Future;General Population;Government;Grant;Health care facility;Health Personnel;Healthcare;Heroin;HIV;HIV Infections;Hybrids;illicit drug use;implementation evaluation;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Injecting drug user;Injections;Intervention;Interview;Link;Logic;Measures;Medical;Mental Health;methadone treatment;Methods;Modeling;Outcome;Participant;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;physical conditioning;Play;Prevalence;Prevention;prevention service;Principal Investigator;Process;Proctor framework;Property;Psychometrics;Quality of life;Random Allocation;Recovery;Reporting;Research;research study;Role;Sampling;social stigma;Source;Surveys;Tanzania;treatment services;Validity and Reliability;Work

PROJECT_TITLE: Adapting evidence-based stigma reduction interventions to address HIV and drug use stigma among family members of people who use drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Multiple myeloma is the second most common hematologic cancer in the US with an estimated 34,920 new cases and 12,410 deaths to occur in 2021. Black individuals have a dramatically higher incidence of multiple myeloma, as well as a higher rate of mortality from multiple myeloma, compared with White individuals, likely due to several, complex risk factors, such as genetics and differences in exposure to established multiple myeloma risk factors, such as obesity. The proposed project's goal is to inform the clinicians and policymakers whether undertreatment, in addition to biology, is responsible for the poorer outcomes observed among Black patients with multiple myeloma.

PI_NAMEs: GASOYAN, HAMLET  (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: access disparities;Adult;American;Area;Award;Biology;black patient;Black Populations;Bortezomib;Cancer Center;cancer health disparity;cancer site;care costs;Caring;Cessation of life;Clinical;Communities;Complex;cost;Cost Sharing;COVID-19 pandemic;COVID-19 pandemic effects;Data;Databases;Death Rate;Deductibles;deprivation;Dexamethasone;Diagnosis;Disparity;Drug Prescriptions;Electronic Health Record;experience;Exposure to;follower of religion Jewish;Genetic;Goals;Health;health data;Health Insurance;health plan;Health Policy;Health Services Research;Healthcare;Hematologic Neoplasms;Incidence;indexing;Individual;Inpatients;Insurance;Insurance Coverage;Knowledge;Lead;lenalidomide;Maintenance Therapy;Medicaid;Medical;Medicare;member;Mentors;mortality;Multiple Myeloma;Neoadjuvant Therapy;Newly Diagnosed;novel;novel therapeutics;Obesity;Obesity associated cancer;Oral;Outcome;outcome disparities;Outpatients;pandemic disease;Pathway interactions;Patients;Patterns of Care;peer;Persons;Pharmaceutical Preparations;Phase;Policy Maker;Postdoctoral Fellow;pre-pandemic;Productivity;Race;racial disparity;racial population;Regimen;Research;Research Personnel;Research Training;residence;Retrospective cohort;Risk Factors;Role;skills;social;social health determinants;Stem cell transplant;Time;Training;Treatment Cost;treatment pattern;Treatment Protocols;Triplet Multiple Birth;underserved community;Underserved Population;Uninsured Medical Expense;Urbanicity

PROJECT_TITLE: Modifiable Determinants of Disparities in Multiple Myeloma Treatment Patterns


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cancer;Hematology;Lymphatic Research;Lymphoma;Mental Health;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Sleep Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Cancer-related cognitive impairment (CRCI) is common and distressing among cancer survivors, including those receiving targeted therapy, such as tyrosine kinase inhibitors (TKIs). We propose to study subjective and objective CRCI, identify pre-morbid risk factors, and identify modifiable behavioral and biobehavioral mechanisms. This study aims to provide actionable outcomes for further intervention development in addressing the understudied problem of CRCI among patients receiving TKIs for cancer.

PI_NAMEs: GONZALEZ, BRIAN D (contact);JANELSINS, MICHELLE C;SMALL, BRENT JOHN

PROGRAM_OFFICER_NAME: LEE, CECILIA H

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;actigraphy;Address;Age;age acceleration;anxiety symptoms;Area;Awareness;base;Behavioral;Behavioral Mechanisms;biobehavior;Biological;biological age;Biological Aging;Cancer Center;cancer diagnosis;Cancer Intervention;cancer risk;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;Cellular Phone;Chronic;Chronic Lymphocytic Leukemia;Chronic Myeloid Leukemia;Chronology;circadian;Circadian Dysregulation;Clinical Trials;Cognitive;cognitive performance;Community Clinical Oncology Program;Data;depressive symptoms;Development;Distress;DNA Methylation;Ecological momentary assessment;Education;Exhibits;Fatigue;FDA approved;Future;Generations;Hematologic Neoplasms;Impaired cognition;improved;inhibitor therapy;innovation;Integration Host Factors;Intervention;Lead;leukemia;Longitudinal Studies;Malignant Neoplasms;Measures;Mediating;meetings;Methods;Modeling;modifiable risk;Neuropsychology;Oncology;Outcome;Participant;Patient Care;Patient Outcomes Assessments;Patients;Population;prevent;Process;programs;Prospective Studies;psychologic;Publishing;Recording of previous events;recruit;Research;Risk Factors;saliva sample;sex;Site;Sleep;Sleep disturbances;social health determinants;Statistical Models;Study models;survivorship;targeted treatment;therapy development;trial planning;Tyrosine Kinase Inhibitor;Universities;Work;Wrist

PROJECT_TITLE: Impact of Targeted Therapy on Cancer-Related Cognitive Impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-W (02)]


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cell communication research is a growing field, and the Dynamics and Encoding in Cell Signaling conference is the first conference to bring together an international group of researchers focused on understanding exactly what distinguishes “normal” and “disease” cell signaling behavior in terms of spatial and temporal details. This conference will highlight these efforts and foster collaborations which will result in advancements in biomedical research and tool development.

PI_NAMEs: ALBECK, JOHN G. (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Academia;Acceleration;Address;Area;Behavior;Biochemistry;Biological;Biomedical Research;biomedical scientist;Biosensor;Cancer Biology;career;Career Choice;cell behavior;Cell Communication;Cell Cycle;Cell Physiology;Chronic;Collaborations;Communication;Communication Research;Communities;Computer Analysis;Computer software;design;Development;Diabetes Mellitus;Disease;Disparate;Event;Feedback;Fertilization;Fostering;Funding;Gene Expression;Goals;Health;Home;Human;Image;Image Analysis;Immune;Immune signaling;Immunology;Individual;Industry;Inflammatory;insight;Institution;interest;International;Knowledge;Learning;live cell imaging;Malignant Neoplasms;MAP Kinase Gene;mathematical model;meetings;Mentors;Metabolic;Mission;Modeling;Modernization;NF-kappa B;optogenetics;Pathway interactions;Persons;Physiological;Positioning Attribute;posters;Process;programs;Receptor Mediated Signal Transduction;Research;research and development;Research Personnel;Science;Scientist;Senior Scientist;Signal Pathway;Signal Transduction;skills;Space Models;spatiotemporal;Structure;success;symposium;System;Techniques;Technology;temporal measurement;therapeutic target;Time;Time Series Analysis;tool;tool development;TP53 gene;Training;transmission process;Travel;United States;Woman;Work

PROJECT_TITLE: Dynamics and Encoding in Signal Transduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-E (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Nutrition

PHR: Project Narrative The 2024 FASEB Science Research Conference on “Molecular Metabolism: From Cell Biology to Systems Physiology” is a conference to advance knowledge in the areas of glucose and energy metabolism; a topic highly relevant to age-related disorders such as obesity, diabetes, and cardiovascular diseases. This conference will bring together researchers with expertise in cell signaling, nutrient sensing, metabolic physiology, and systems biology. Interactions among participants are likely to spark new ideas and progress toward novel therapies for treating age-related metabolic diseases.

PI_NAMEs: ELMENDORF, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: age related;age-related disease;American;Area;base;Bioinformatics;Biology;Biotechnology;blood glucose regulation;Body Weight decreased;Businesses;Cardiovascular Diseases;career development;Cells;Cellular biology;Characteristics;Chronic Disease;Clinical;Cloning;Collaborations;combat;Communities;Complex;cost;Cultural Backgrounds;Data;design;detection of nutrient;Development;Diabetes Mellitus;Disease;disorder prevention;drug development;Drug Prescriptions;Educational workshop;Energy Metabolism;Environment;Event;Explosion;Faculty;Fertilization;forging;Funding;GCG gene;glucose metabolism;Glucose Transporter;Goals;Grouping;Health;Homeostasis;Hour;Housing;Imaging technology;Immunity;Industry;insight;Institution;insulin signaling;Knowledge;Laboratories;Link;meetings;member;Metabolic;Metabolic Diseases;Metabolism;Mission;Molecular;Molecular Profiling;Monitor;Motion;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel therapeutic intervention;novel therapeutics;Nutrient;Obesity;Oral;Organ;Organelles;Participant;Pathway interactions;Pharmacologic Substance;Physiology;Positioning Attribute;Postdoctoral Fellow;posters;Process;Productivity;prospective;Protein Isoforms;Regulation;Research;Research Personnel;Role;Running;Science;Scientist;Series;Signal Transduction;Site;social media;Societies;Speed;student participation;Students;success;symposium;synergism;System;Systems Biology;Talents;Therapeutic;tool;Translating;translational goal;Travel;United States National Institutes of Health;volunteer;Voting;Walking

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (M3)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Lung transplantation is the only life-saving intervention for many patients, but it is severely limited primarily due to chronic rejection of the allograft (CLAD). Our data show a significant increase in specific B and plasma cell populations in rejected lungs, both in lungs from a novel mouse model of chronic rejection after orthotopic lung transplantation, as well as in retransplanted CLAD patients. In this application, we will investigate the mechanism of their contribution to rejection and potential therapeutic application for these cell populations.

PI_NAMEs: BUENO FERNANDEZ, MARTA ;EICKELBERG, OLIVER  (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Adaptive Immune System;airway epithelium;allograft rejection;Animal Model;Area;Asthma;B-Lymphocytes;Bronchiolitis Obliterans;Cells;Chronic;Chronic Disease;clinically relevant;Color;Data;Deterioration;Development;Distal;Dose;Epithelial Cells;Expression Profiling;Extrinsic allergic alveolitis;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression Profile;Generations;Genetic Transcription;Goals;Heterogeneity;Human;humoral immunity deficiency;Immune;Immunofluorescence Immunologic;Immunophenotyping;in vivo;Infection;Inflammation;Innate Immune System;insight;interstitial;Intervention;Kinetics;Knockout Mice;Knowledge;Life;Lung;lung allograft;Lung Diseases;lung preservation;Lung Transplantation;Maps;Measurement;mouse model;Mus;novel;novel therapeutics;Organ Transplantation;Pathogenesis;Pathogenicity;Patients;Phenotype;plasma cell differentiation;Plasma Cells;Population;Population Dynamics;Population Heterogeneity;prevent;Prevention;progenitor;Proteins;pulmonary function;Pulmonology;Regimen;retransplantation;Risk;Role;single-cell RNA sequencing;Solid;spatiotemporal;Syndrome;Testing;Therapeutic;Time;Tissues;Transplant Recipients

PROJECT_TITLE: Role of plasma cells in chronic rejection after lung transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision

PHR: PROJECT NARRATIVE The Hippo pathway functions in a wide range of key physiological processes and its dysregulation contributes to multiple human diseases, particularly cancer. Research of the Hippo pathway and its translational applications is a rapidly growing field. This application seeks to secure conference funding support to bring together a diverse group of leading scientists and young investigators through the “2024 FASEB Scientific Research Conference: Hippo pathway in Biology and Diseases” to foster scientific exchange and collaboration in the fundamental biology of the Hippo pathway and therapeutic development of related cancer drugs.

PI_NAMEs: WANG, WENQI  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Academia;Acceleration;anti-cancer research;Apoptosis;Award;Biological;Biological Models;Biology;cancer therapy;career;Career Choice;career development;Collaborations;Collection;Country;Development;Dimensions;Disease;doctoral student;drug development;drug related cancer;Educational workshop;Environment;Event;experience;Faculty;Fertilization;Florida;Fostering;Funding;Gender;Generations;Genetic;Goals;Growth;Homeostasis;Human;human disease;Immunology;Individual;Industry;industry partner;Inflammation;insight;interdisciplinary collaboration;Knowledge;Lightning;Location;Malignant Neoplasms;meetings;Minority Groups;Natural regeneration;next generation;Organ Size;Pathway interactions;Physiological Processes;Physiology;Postdoctoral Fellow;posters;programs;Proliferating;Publishing;Race;Regulation;Research;Research Personnel;Science;Scientific Advances and Accomplishments;Scientist;Secure;Series;Signal Pathway;Signal Transduction;stem cells;Stimulus;symposium;The Cancer Genome Atlas;therapeutic development;therapeutic target;tissue regeneration;Tissues;Training;translational applications;Travel;Tumor Immunity;tumorigenesis;Underrepresented Minority;Underrepresented Populations;Universities;Woman;Writing

PROJECT_TITLE: Hippo Pathway in Biology and Diseases


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative α-Synuclein protein levels closely correlate with the risk of several neurodegenerative diseases, including Parkinson’s Disease and dementias related to Alzheimer’s Disease, termed ADRDs. We recently found, using unbiased genome-wide screening approaches, that loss of α-synuclein N-terminal acetylation results in a stark reduction in endogenous protein levels in both model cell lines and neurons. Based on these results, we will investigate the role of this modification in α-synuclein biology and develop the first small molecule inhibitors of the NatB enzyme complex responsible for N-terminal acetylation of α-synuclein that we will evaluate for their therapeutic potential in Parkinson’s Disease and ADRDs.

PI_NAMEs: MARMORSTEIN, RONEN ;PETERSSON, ERNEST JAMES;RHOADES, ELIZABETH  (contact);SHALEM, OPHIR

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biology;Biophysics;candidate identification;Cell Line;Cell model;Cell Physiology;Cells;Cellular biology;Chemicals;Compensation;Complex;CRISPR screen;Data;Dementia;dementia risk;Development;Disease;disease model;disorder risk;Evaluation;follow-up;Fractionation;Generations;Genes;Genetic;genome wide screen;Goals;high throughput screening;Human;Human Cell Line;Image;in silico;In Vitro;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;insight;Investigation;knock-down;Lead;Ligase;Ligation;Machine Learning;Measures;Mediating;Membrane;Modality;Modification;Molecular;Molecular Biology;Multienzyme Complexes;N-terminal;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;novel therapeutics;Outcome;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;pharmacologic;Post-Translational Protein Processing;Process;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;Radioactive;Regulation;Repression;Research;Resistance;Risk;Role;screening;Screening Result;small molecule;small molecule inhibitor;structural biology;Structure;synucleinopathy;targeted treatment;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;tool;Ubiquitination;uptake

PROJECT_TITLE: Role of N-terminal acetylation in alpha synuclein stability, function, and therapeutic targeting in synucleinopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In this application, we will define mechanisms underlying novel pathways that lead to divergent outcomes during P. aeruginosa and S. aureus interactions. We will also investigate how a prior S. aureus infection of innate immune cells results in a blunted response to secondary infection. The overall hypothesis of this study is that a better mechanistic understanding of antagonistic and cooperative interactions between these two pathogens will lay the foundation for strategies to modulate these pathways for better control of mixed-species infections.

PI_NAMEs: PARSEK, MATTHEW R.;WOZNIAK, DANIEL J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Animal Model;antagonist;antimicrobial;Antioxidants;Attention;Attenuated;Autolysis;Awareness;Bacteria;Behavior;Binding;Biochemical;Biological;Biological Assay;Carotenoids;Cells;Chronic;chronic infection;chronic wound;Clinical;co-infection;Coculture Techniques;Communities;Complex;Cooperative Behavior;Cystic Fibrosis;cystic fibrosis patients;Development;Diagnosis;Disease Outcome;Epigenetic Process;Evolution;experimental study;Exposure to;Foundations;fungus;Gene Expression Profiling;Gene Silencing;Genetic;Genetic Screening;Goals;Growth;Host Defense;Human;human pathogen;Hydrogen Peroxide;Immune;Immunity;implantable device;In Vitro;in vivo;Infection;Inflammatory;Innate Immune Response;Lead;Lung;Macrophage;Macrophage Activation;Mediating;Medical Device;Medicine;Metabolic;Microbial Biofilms;Microbial Genetics;microorganism interaction;model organism;Modeling;Molecular;monocyte;Mus;mutant;neutrophil;novel;Nutrient availability;Operon;Organism;Outcome;Oxidative Stress;Oxides;Parasites;pathogen;Pathway interactions;Patient-Focused Outcomes;Persons;Pigments;Polysaccharides;Prevalence;prevent;Primary Infection;Production;programs;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;quorum sensing;Research;Resistance;response;Risk;Role;Sampling;screening;secondary infection;Secondary to;Seminal;Spatial Distribution;Staphylococcal Protein A;Staphylococcus aureus;Staphylococcus aureus infection;staphyloxanthin;Surface;System;Training;transcriptomics;Virus;Work;wound

PROJECT_TITLE: Cooperation and antagonism in polymicrobial infection

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The protein ERG is a known driver of prostate cancer. We are proposing to develop small molecule inhibitors of ERG. Targeted ERG inhibitors have the potential to improve the long-term survival of prostate cancer patients while reducing side effects from standard-of-care treatments due to less toxicity.

PI_NAMEs: BUSHWELLER, JOHN HACKETT (contact);GIOELI, DANIEL G;HAGEMAN, MICHAEL

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Allosteric Site;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;antagonist;Anti-androgen Therapy;Apoptosis;Binding;Biochemical;Biological Assay;Biological Models;cancer diagnosis;Cancer Patient;Cell Cycle;Cell Death;Cells;cellular targeting;Cessation of life;chemoproteomics;ChIP-seq;Chromatin;Chromosomal translocation;Clinic;cohort;commercialization;Coupled;Data;Development;Disease;DNA Binding;drug development;Drug Kinetics;Drug resistance;efficacy evaluation;efficacy study;Endothelial Cells;Evaluation;Family;Formulation;Gene Expression;Gene Fusion;Generations;Genes;Genome;genome-wide;Grant;Growth;Human;Immune Evasion;improved;in vivo;in vivo evaluation;inhibitor;Ligands;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;men;meter;migration;Mus;nanomolar;Nature;novel;novel therapeutic intervention;overexpression;patient derived xenograft model;Patients;Precision Run-On Sequencing;preclinical evaluation;Production;Prognosis;Proliferating;Property;prostate cancer cell line;prostate cancer model;Prostate Cancer therapy;Proteins;Reaction;Recurrence;Resistance development;response;Role;side effect;small molecule;small molecule inhibitor;Specificity;standard of care;stemness;steroid hormone;Structure-Activity Relationship;System;Testing;therapeutic target;Tissue Model;TMPRSS2 gene;Toxic effect;Transcript;transcription factor;translational pipeline;Work

PROJECT_TITLE: Small Molecule ERG Inhibitors for Prostate Cancer

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Merkel cells (MCs) are essential for sensing light touch. During aging, MC numbers decrease, resulting in alloknesis, a condition where light mechanical stimuli cause itch. By exploring processes controlling MC numbers and mediating mechanical itch, as well as by investigating the regeneration of MCs, we aim to provide new avenues for the design of treatments for preventing age-related decreases in MCs and associated alloknesis.

PI_NAMEs: EZHKOVA, ELENA  (contact);HU, HONGZHEN

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Ablation;Acetone;Adult;Afferent Neurons;age related;age related decline;aged;Aging;Amyloid beta-Protein;Automobile Driving;Behavioral Assay;C Fiber;Candidate Disease Gene;candidate identification;Cell Count;Cell Differentiation process;Cell Proliferation;cell regeneration;Cells;Communication;Complex;Coupled;Dryness;Elderly;Ethers;Experimental Models;experimental study;Fiber;fiber cell;gain of function;Gene Expression Profiling;Genes;Genetic;genetic manipulation;Genetic study;Genetic Transcription;Homeostasis;Human;insight;keratinocyte;Ligands;Light;loss of function;Mechanical Stimulation;mechanical stimulus;Mechanics;Mediating;Merkel Cells;Modeling;Molecular;molecular dynamics;mouse model;Mus;Natural regeneration;Neuroepithelial;Neurons;Neuropeptides;novel therapeutic intervention;old mice;Pathologic;Perception;Phenotype;Pilot Projects;Play;prevent;Process;programs;Proliferating;Pruritus;receptor;Recovery;Research;response;RNA;Role;single-cell RNA sequencing;Skin;Skin Abnormalities;Source;stem cells;Substance P;Tenascin;Testing;Therapeutic Intervention;therapy design;Touch sensation;TRPV1 gene;Water;water treatment

PROJECT_TITLE: Cellular and Molecular Mechanisms Underlying Merkel Cell Loss and Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Nitric oxide (NO) is a free radical signaling molecule that is necessary for normal physiology, but it is also associated with numerous pathologic conditions. Mechanisms to explain how NO regulates gene expression in various disease settings are not known. Studies in this proposal will investigate a novel molecular mechanism of how different concentrations of NO controls DNA and RNA methylation to regulate gene expression.

PI_NAMEs: THOMAS, DOUGLAS D. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: adduct;Affect;Affinity;alpha ketoglutarate;Attenuated;base;Binding;Biological Assay;Cell Line;Cell model;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;demethylation;Development;dinitrosyl iron complex;Disease;Enzyme Inhibition;enzyme substrate;Enzymes;Epigenetic Process;Etiology;Family;fat mass and obesity-associated protein;Free Radicals;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic Transcription;Guanylate Cyclase;Homeostasis;inhibitor;Iron;iron oxide;Kinetics;Ligands;Link;Measures;Mediating;Mediator;Messenger RNA;Metals;Methylation;Modification;Molecular;Mononuclear;nanomolar;neurotransmission;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;Physiology;Play;Process;Promoter Regions;Protein Isoforms;Proteins;Publications;Regulation;Regulator Genes;RNA;RNA methylation;Role;scaffold;Sex Functioning;Signal Transduction;Signaling Molecule;Site;Structure-Activity Relationship;Techniques;Transcript;Translations;Vasodilation;virulence gene;X-Ray Crystallography

PROJECT_TITLE: Nitric oxide inhibits Iron(II)2-Oxogluterate dependent demethylases to regulate DNA and mRNA methylation

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Assistive Technology;Bioengineering;Brain Disorders;Dementia;Infectious Diseases;Neurosciences;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Neurogenic lower urinary tract dysfunction (NLUTD) is widely prevalent in patients with neuromuscular disorders and aging and imposes a drastic impact on quality of life2,10,11. Urinary symptoms secondary to NLUTD (urinary frequency, urgency, incontinence, and retention) are often managed with medical devices, ranging from simple urinary catheters to sacral neuromodulation. With the proposed and innovative 2024 meeting, we aim to create the first multi-specialty meeting focused on engineering solutions to augment the quality of life of patients with NLUTD.

PI_NAMEs: KHAVARI, ROSE  (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: Address;Advertising;Affect;age related;Aging;Agreement;Alzheimer's Disease;Area;Artificial Urinary Sphincter;Asian;associated symptom;Bladder;career;Caring;Catheterization;Catheters;Censuses;Child;Cities;clinical practice;Combination Medication;Committee Members;Communities;Contracts;County;Dedications;Dementia;design;Development;Device Designs;Devices;Diabetic Neuropathies;Disease;doctoral student;empowerment;Engineering;Ensure;Ethnic Population;Etiology;Event;experience;Face;Female;Fostering;Foundations;Functional disorder;Funding;Future;General Population;Goals;Government;Grant;Group Affiliation;Guidelines;Hispanic;improved;Incontinence;Increased frequency of micturition;Individual;Injury;innovation;interest;kidney dysfunction;Knowledge;Latino;lectures;Life Style;Location;Longevity;Lower urinary tract;marginalized population;Medical Device;medical specialties;Medical Students;meetings;member;men;Mentorship;Minority Participation;Mission;multidisciplinary;Multiple Sclerosis;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Aging;Neurogenic Bladder;Neurologic;neurological pathology;Neurology;Neuromuscular Diseases;neuroregulation;neurosurgery;Operative Surgical Procedures;Outcome;Outcomes Research;Parkinson Disease;Participant;patient population;Patient Representative;Patient-Focused Outcomes;Patients;Pediatrics;Population;practical application;Quality of life;racial population;recruit;Recurrence;Reporting;Research;research and development;Research Personnel;Risk;Risk Factors;Role;Science;Scientist;Secondary to;Series;Severities;side effect;skills;Societies;Source;Sphincter;Spinal cord injury;Spinal Dysraphism;Stroke;stroke patient;Structure of tibial nerve;Students;success;symposium;Symptoms;System;technological innovation;Technology;Training;Trauma;Travel;Urethra;Urethral Stricture;urinary;Urinary Catheterization;Urinary Incontinence;Urinary Retention;Urinary tract infection;urologic;Urology;Writing

PROJECT_TITLE: Neurogenic Bladder Research Group (NBRG) symposium: Partnering with Engineering in Neurogenic Bladder Research


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: DOYLESTOWN

ORG_NAME: HEPATITIS B FOUNDATION

PHR: Project Narrative Hepatitis B virus (HBV) chronically infects 290 million people world-wide and causes liver cancer and liver failure for which there are no curative treatments, so there is an urgent need to develop better antiviral therapies. The International HBV Meeting is the only meeting that brings together scientists studying HBV and its satellite hepatitis delta virus (HDV) to present and discuss the newest fundamental discoveries of HBV and HDV biology that have the potential to evolve into new antiviral approaches for curing HBV and HDV infections, thereby preventing the development of the associated liver diseases. This application seeks funding for travel grants to support attendance of early-stage investigators and under-represented scientists at the HBV meeting to maximize diversity of attendees and the variety of ideas and opinions that they bring with them.

PI_NAMEs: PLOSS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Achievement;Affect;Animal Model;Animals;Anti-viral Therapy;Asia;Australasia;Australia;Award;Basic Science;Biochemistry;Biology;Biomedical Research;career;Cell model;Cellular biology;Cessation of life;Chicago;Chronic;Chronic Hepatitis B;chronic infection;Clinical Research;Collaborations;Communities;community engagement;cost;curative treatments;Data;Development;disadvantaged background;Disadvantaged minority;Disease;drug development;effective therapy;Effectiveness;Ensure;Europe;Far East;Financial Support;Foundations;Funding;Gene Expression;gene therapy;General Population;Goals;graduate student;Grant;Hepatitis B;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis Delta Virus;Human;Immunology;In Vitro;in vivo;Industrialization;Infection;interest;International;Investigational Therapies;lectures;Liver Cirrhosis;liver development;Liver diseases;Liver Failure;low and middle-income countries;Malignant neoplasm of liver;meetings;minority investigator;Mission;Molecular;Molecular Biology;National Cancer Institute;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;new technology;novel strategies;novel therapeutic intervention;Oral;pathogen;Pathogenesis;patient oriented;Persons;Postdoctoral Fellow;posters;posttranscriptional;prevent;Primary carcinoma of the liver cells;programs;prophylactic;protein expression;Public Health;Reagent;Regulator Genes;Reporting;Research;Research Personnel;Resources;RNA Editing;Rotation;Scientist;Senior Scientist;Site;Students;success;symposium;Technology;therapy development;tool;Travel;Underrepresented Minority;United States National Institutes of Health;vector;Viral;virology;Virus;Virus Diseases;virus related cancer

PROJECT_TITLE: 2024 International Meeting on the Molecular Biology of Hepatitis B Viruses (International HBV Meeting)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-D (M1)]


NIH_SPENDING_CATS: Biotechnology;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_NAME: INTERNATIONAL SOCIETY/EXPER HEMATOLOGY

PHR: The International Society for Experimental Hematology’s (ISEH) Annual Scientific Meeting blends high-impact scientific sessions with approachable networking opportunities to create an important forum for scientists at every level of their career, including students, postdoctoral fellows, junior faculty, and senior faculty who focus on advancing the areas of hematology, hematologic disorders, stem cell biology, cell therapy and immuno-oncology. Our scientific program is structured to include one day of pre-meeting workshops for PhD students, postdoctoral fellows and junior faculty, followed by three days of world-leading scientific talks and networking activities for all attendees. Through a mixture of invited speakers and oral abstract presentations featuring talks on basic, translational and clinical hematology, ISEH is known as a meeting to both hear the latest scientific achievements and unpublished research, as well as an opportunity for field’s rising stars to receive their first opportunities to present at an international scientific meeting in an inclusive, safe and welcoming environment. The critical networking enabled at ISEH’s meeting advances the next generation of scientific leaders in experimental hematology, resulting in the translation of discoveries into drug development and critical therapies.

PI_NAMEs: STRANG, KATIE MARIE (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Achievement;Area;Award;base;career;Career Choice;career development;career networking;Cell Therapy;Cellular biology;Chicago;Clinical;clinical application;Collaborations;cost;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;drug development;Educational workshop;Environment;Event;Experimental Hematology;Faculty;Feedback;Fellowship;Fertilization;Fostering;Functional disorder;Funding;Future;gene therapy;Geographic Locations;Geography;Goals;Grant;Hearing;Hematological Disease;Hematology;Hematopoietic stem cells;Immunology;Immunooncology;innovation;International;Knowledge;Laboratories;Leadership;Learning;lectures;Location;meetings;member;Mentors;Mission;Molecular Biology;new technology;next generation;Oral;Pluripotent Stem Cells;Positioning Attribute;Postdoctoral Fellow;posters;professor;programs;Publications;Recording of previous events;Research;Research Personnel;Science;scientific organization;Scientist;senior faculty;Services;skills;Societies;stem cell biology;Stem Cell Research;Structure;Students;success;supportive environment;symposium;Techniques;Technology;Time;Training and Education;Transferable Skills;Translations;Travel;Writing

PROJECT_TITLE: ISEH 53rd Annual Scientific Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M4)]


ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms by which the intestinal epithelium regulates its gene expression in response to microorganisms is expected to lead to new approaches for preventing or treating intestinal infections and inflammation. The proposed research is therefore relevant to the part of NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: RAWLS, JOHN F (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Animals;antimicrobial;Bacteria;Binding;Biology;burden of illness;Cell Differentiation process;Cell Proliferation;Cells;Chromatin;Co-Immunoprecipitations;Communication;Cytosol;Data;Development;dietary;enteric infection;enteric virus infection;Enterocytes;Enterovirus;Enterovirus Infections;Epithelial Cells;Family;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Gnotobiotic;Goals;gut inflammation;gut microbiota;Health;Heterogeneity;HNF4A gene;Homeostasis;host-microbe interactions;Human;human disease;Immune;Immune signaling;Immunologics;immunoregulation;Infection;Inflammation;insight;Interferons;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;IRF3 gene;Knowledge;Mass Spectrum Analysis;Mediating;Metabolism;Microbe;microbial;microbiota;microorganism;Mission;Modeling;Molecular;Mus;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Nuclear Translocation;nutrient absorption;nutrient metabolism;Outcome;Pathway interactions;Pattern recognition receptor;Physiology;Post-Translational Protein Processing;prevent;prognostic;programs;Proliferating;Proteomics;Public Health;Receptor Activation;Regulation;Research;Resolution;response;Role;Signal Induction;Signal Pathway;Signaling Protein;single-cell RNA sequencing;Tertiary Protein Structure;Testing;Therapeutic;transcription factor;Transcriptional Regulation;United States National Institutes of Health;Viral;viral detection;Viral Genes;Virus;Wild Type Mouse;Zebrafish

PROJECT_TITLE: Microbial regulation of intestinal epithelial gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE The proposal focuses on conduct problems (CP) in young children, particularly the amplifying effects of callous-unemotional (CU) behaviors and the potential buffering effects of parental emotion socialization. The study aims to determine the convergence of physiological functioning, observed empathy, and parent/teacher ratings into a single CU construct, assess within and between person variability in initial levels of CU and over time, and examine how parental emotion socialization may potentially mitigate the negative impact of CU on CP severity one year later.

PI_NAMEs: HERNANDEZ, MELISSA LYNN (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Accounting;Adolescence;Adult;Aggressive behavior;antisocial behavior;Attenuated;Behavior;behavior observation;Behavioral;behavioral outcome;Buffers;callous unemotional trait;Caring;Child;Child Rearing;Clinical;Code;comorbidity;Conduct Disorder;conduct problem;Data;Data Analyses;Development;Diagnostic;Distress;DSM-V;early childhood;Early Intervention;early onset;Effectiveness;Emotional;emotional experience;emotional functioning;Emotions;Empathy;Evidence based treatment;Exhibits;Face;Financial cost;Guilt;heart rate variability;high risk;Image;Impairment;in vivo;Individual;inter-individual variation;Irritable Mood;Language;Life;Link;Measures;Medical;Methods;mimicry;multimodality;Nature;Oppositional Defiant Disorder;Outcome;Parasympathetic Nervous System;Parent-Child Relations;parental influence;parental role;parenting intervention;Parents;Pattern;Persons;Physiological;Play;positive emotional state;Preschool Child;Proxy;Reaction;Reporter;Reporting;Research;response;Role;Sampling;Services;Severities;Shapes;social;Socialization;societal costs;Special Education;Symptoms;System;teacher;Time;Treatment outcome;Validity and Reliability

PROJECT_TITLE: Multimodal Assessment and Longitudinal Trajectory of Callous-Unemotional Behaviors in Young Children: The Role of Parental Emotion Socialization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Nanotechnology;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: The proposed research is relevant to public health as it develops enabling technologies for gene editing in skeletal muscle. Current rates of gene editing in this tissue are low and methods are lacking for how to control expression of gene editing enzymes in this tissue. We will develop new technologies to 1) edit as many myonuclei as possible in the context of the myofiber syncytia, 2) control expression of gene editing enzymes, and 3) integrate these elements into a single gene therapy vector.

PI_NAMEs: WANG, ERIC T (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;adeno-associated viral vector;Alternative Splicing;antibody conjugate;Architecture;Autologous Transplantation;Back;base editing;base editor;BCAR1 gene;behavior test;Bone Marrow;Capsid;Cell Nucleus;cell type;Cells;Climacteric;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Creativeness;CRISPR/Cas technology;Cytoplasm;debilitating pain;Dependovirus;design;Disease;DNA cassette;Dose;Duchenne muscular dystrophy;Elements;Enzymes;Estrogen Receptors;experience;Facioscapulohumeral;Familial Hypercholesterolemia;FDA approved;fictional works;Gene Delivery;gene editing technology;Gene Expression;Gene Transduction Agent;gene-editing approach;Generations;Genes;genome editing;Giant Cells;Goals;Guide RNA;Hematopoietic stem cells;Image;immune activation;Immune response;improved;in vivo;Individual;insight;Limb-Girdle Muscular Dystrophies;lipid nanoparticle;Literature;Liver;Low-Density Lipoproteins;Messenger RNA;Methods;Microtubules;miniaturize;Modality;mouse model;mRNA delivery;Muscle;muscle progenitor cell;Muscular Dystrophies;muscular dystrophy mouse model;Myopathy;Myotonic Dystrophy;Myotonic dystrophy type 1;new technology;next generation;novel strategies;Nuclear;Nuclear Export;Nuclear Import;nucleocytoplasmic transport;Patients;Peptides;Pharmaceutical Preparations;progenitor;protein expression;Proteins;Public Health;Quality Control;Regulation;Research;RNA;RNA Splicing;RNA-Binding Proteins;Route;Safety;Science;screening;Sickle Cell Anemia;single molecule;skeletal;Skeletal Muscle;small molecule;Speed;System;Technology;Testing;Time;Tissues;transgene expression;Transgenes;translational potential;Viral;Work

PROJECT_TITLE: Technologies to enable safe and effective gene editing in skeletal muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative There are many children exposed to opioids during pregnancy, who frequently have behavioral problems and lower school achievement along with changes seen on brain MRI scans compared to children who are not exposed. In this multi-center study, our center is one of four centers that has enroll infants exposed to opioids and controls who are not exposed, and is following them over time with careful evaluation of their brain structure by MRI scans and detailed examination of their development and behavior to determine the relative effects of opioid exposure in pregnancy and poor environment on their development.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM  (contact);PERALTA-CARCELEN, ADA MYRIAM

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 2 year old;Achievement;Age;Age Months;anxiety symptoms;Award;Behavior;Behavioral;Birth;Brain;brain magnetic resonance imaging;brain volume;Cephalic;Cerebrum;Certification;Child;Child Rearing;Childhood;clinical center;Clinical Research;clinical research site;cohort;Collaborations;Communication;connectome;Data;Data Coordinating Center;data repository;Deposition;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Enrollment;Environment;Evaluation;experience;Exposure to;fetal opioid exposure;follow-up;Funding;Goals;Grant;gray matter;Healthcare;high risk infant;Home environment;improved;Infant;Infrastructure;International;Laws;Life;Longitudinal Studies;Magnetic Resonance Imaging;Manuscripts;Measures;Medical;Mental Health;Mothers;MRI Scans;Multicenter Neonatal Research Network;Multicenter Studies;National Institute of Child Health and Human Development;Neonatal;neurodevelopment;neuroimaging;Newborn Infant;Opioid;opioid exposure;opioid use;opioid use in pregnancy;Outcome;participant retention;Policies;Population;postnatal;Pregnancy;Problem behavior;Procedures;Productivity;programs;Protocols documentation;Psychotropic Drugs;Publications;Publishing;Questionnaires;Regulation;Research;response;Rest;Schools;Site;social stigma;Standardization;Structure;success;Time;Tissues;Training;Umbilical cord structure;United States National Institutes of Health;Visit;white matter injury

PROJECT_TITLE: UAB Outcomes of Babies with Opioid Exposure (OBOE study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-N (55)]


NIH_SPENDING_CATS: Brain Disorders;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative  Malaria is one of the world’s most common and deadly infectious diseases. Approximately 627,000 people, mostly African children, die each year due to complications of malaria (WHO estimate for 2021). This project will investigate the mechanism by which knobs on the surface of Plasmodium falciparum infected erythrocytes are assembled and mediate the adhesion of infected human erythrocytes to endothelial cells.

PI_NAMEs: CHISHTI, ATHAR H. (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: activated protein C receptor;adhesion receptor;Adhesions;Africa South of the Sahara;African;asexual;Atomic Force Microscopy;Attenuated;attenuation;Binding Proteins;Biochemical;Blood;Blood capillaries;Blood Platelets;Blood Vessels;C-terminal;CD36 gene;Cell Communication;Cell Line;Cells;Cerebral Malaria;cerebral microvasculature;Cerebrum;Child;Communicable Diseases;Complementary DNA;Confocal Microscopy;Cytoplasm;Cytoskeleton;Data;Deposition;Development;Disease;domain mapping;Electrons;Encapsulated;Endothelial Cells;Endothelium;Erythrocytes;Evaluation;Falciparum Malaria;Gene Proteins;Genetic;Grant;Head;Histidine;histidine-rich proteins;Human;ICAM1 gene;Imaging Device;In Vitro;in vivo;Infection;inhibitor;Intervention;Kinetics;knob protein;knock-down;Laboratories;Malaria;Mass Spectrum Analysis;Mediating;Membrane;Microscopy;Morphology;novel;novel therapeutic intervention;Organ;Parasites;Pathologic;Peptides;Permeability;Persons;Phage Display;pharmacologic;Phenotype;Plasmodium falciparum;polypeptide;postcapillary venule;Pregnancy;prevent;Process;protein complex;protein function;Proteins;Protocols documentation;real time monitoring;receptor;Receptor Cell;Recombinant Proteins;Recombinants;reconstitution;Scanning;self assembly;Shapes;Structure;Surface;Tail;Techniques;Technology;Testing;Therapeutic;Vascular Endothelium;Western Blotting

PROJECT_TITLE: Mitigation of erythrocyte adhesion in human malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (02)]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Variants in βII-spectrin, a critical component of the neuronal cytoskeleton, causes the neurodevelopmental SPTBN1 syndrome. However, the neuronal types and pathways that are most vulnerable to deficiencies in βII- spectrin function are largely unexplored. These studies aim to define molecular and cellular neuronal pathways modulated by βII-spectrin in the cerebellum and their contribution to SPTBN1 syndrome.

PI_NAMEs: LORENZO, DAMARIS N (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Absence Epilepsy;Action Potentials;Affect;Ankyrins;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Axon;Behavior;Behavioral Paradigm;Binding;Biochemical;Brain;Cell Physiology;Cerebellum;Childhood;Clinical;clinically relevant;Cognition;Cognitive;cognitive function;Communication;Complex;Cytoskeleton;de novo mutation;defined contribution;Dendrites;density;Development;Disease;disease model;Electrophysiology (science);Epilepsy;Exhibits;Exocytosis;experimental study;F-Actin;Fiber;Functional disorder;global developmental delay;Goals;granule cell;Hyperactivity;Image;imaging modality;Impairment;Individual;Intellectual functioning disability;Kinetics;Knock-in Mouse;Length;Link;live cell imaging;Membrane;Microfilaments;Molecular;Motor;mouse model;Movement;Mus;mutant;Neurodevelopmental Disorder;Neurologic;neuron component;neuronal excitability;Neurons;neurotransmission;novel;Output;Pathogenicity;Pathway interactions;Performance;Physiologic pulse;Play;presynaptic;Proteomics;Purkinje Cells;Reporting;retrograde transport;risk variant;Role;scaffold;SCN2A protein;Seizures;Signal Transduction;Site;social;Social Functioning;Sodium Channel;Spectrin;superresolution microscopy;Symptoms;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Syndrome;Techniques;Tonic Seizures;trafficking;Transgenic Mice;Variant;vesicle transport;vesicular release

PROJECT_TITLE: Cytoskeletal pathways of cerebellar dysregulation in neurodevelopmental disorders

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: SOCIAL SCIENCES

PHR: Public Health Relevance Information on how the risk of death varies with age during the late fetal and neonatal periods in resource-poor settings such as the sub-Saharan African countries of focus in this study represents critical evidence for health policy. This information, together with risk factors such as preterm, low birthweight and small for gestational age, will help understand which newborns are most at risk of death, guide policy action and improve progress for children. The present study will make important substantive and methodological contributions to understanding the dynamics of late fetal and neonatal mortality in the sub-Saharan Africa context, with implications for other low-income countries where stillbirth and neonatal mortality rates remain high.

PI_NAMEs: GUILLOT, MICHEL  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse birth outcomes;Africa South of the Sahara;African;Age;Area;Biological;Birth;Birth Weight;boys;Cessation of life;Child;Country;Data;Data Collection;Death Rate;Demographic and Health Surveys;Environment;Ethiopia;Excess Mortality;fetal;Gambia;Gender;Gestational Age;girls;global health;Goals;Guinea-Bissau;Health;Health Policy;improved;Infrastructure;innovation;Joints;Late Fetal Mortality;Live Birth;Low Birth Weight Infant;low income country;Measurement;Methodology;Monitor;mortality;mortality risk;Neonatal;Neonatal Mortality;neonatal period;Newborn Infant;novel;nutrition;Outcome;Pattern;Play;Policies;Population;Population Sizes;postneonatal mortality;Pregnancy;Premature Birth;prospective;Protocols documentation;public health relevance;Resource-limited setting;Risk;Risk Factors;Role;sex;Site;Small for Gestational Age Infant;social;Source;stillbirth;Sustainable Development;Time;ultrasound

PROJECT_TITLE: Nutrition, late fetal and neonatal mortality in the African context

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Identifying modifiable risk factors to reduce and prevent aging-related disease and disability is a public health priority. Toxic and essential metals have individually been linked to cognitive function and dementia, but little is known about joint actions in a mixture on cognitive function, mild cognitive impairment, or novel DNA methylation-based biomarkers of aging. This proposal supports the mission of the NIEHS to inform policy and population-level interventions by identifying modifiable determinants of neurodegenerative disease and assessing vulnerability from co-exposures to environmental and social stressors.

PI_NAMEs: MOON, KATHERINE A (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: accelerated epigenetic aging;Address;Adrenal Glands;Advisory Committees;Age;age acceleration;age related biomarkers;Aging;aging biomarker;aging related;aging related disease;Algorithms;Area;Award;Baltimore;Behavioral;Biological;Biological Markers;Biological Specimen Banks;Blood;bone lead;Brain;Cadmium;Cardiovascular system;causal model;Central Nervous System;Chemicals;Chronic;Chronic stress;Chronology;Clinic Visits;Cognition;Cognitive;Cognitive aging;cognitive function;Communities;Data;Dementia;disability;Discrimination;disparity elimination;DNA Methylation;Enrollment;Environmental Exposure;Environmental Hazards;Environmental Risk Factor;environmental stressor;Epidemiology;epidemiology study;Epigenetic age;epigenetic marker;Epigenetic Process;epigenomics;Ethnic Origin;experience;Exposure to;Factor Analysis;Fluorescence;Functional disorder;genome-wide;Goals;hazard;Health;health disparity;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impaired cognition;Individual;Intervention;Joints;Lead;lead dose;Link;Longitudinal cohort study;Manganese;Measurement;Measures;Memory;Mentors;Mercury;Metabolic;Metabolic Pathway;Metals;Methodology;mild cognitive impairment;Mission;Modeling;modifiable risk;Modification;mortality;National Institute of Environmental Health Sciences;Neighborhoods;Neurodegenerative Disorders;Neurotoxins;novel;older adult;Older Population;Outcome;Participant;Pathway interactions;Persons;Phase;Physiological;Pituitary Gland;Policies;Population;Poverty;prevent;psychosocial;public health priorities;Race;Research Personnel;Residual state;Risk;Risk Factors;Roentgen Rays;Role;Saliva;Sampling;social factors;social stressor;Socioeconomic Status;Statistical Models;stressor;theories;tibia;Toxic Environmental Substances;toxic metal;Trace Elements;Training;Urine;Visit

PROJECT_TITLE: The role of toxic and essential metal mixtures, and co-exposures to social stressors, in cognitive aging, mild cognitive impairment, and novel epigenetic age biomarkers: The Baltimore Memory Study

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CLEVELAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Current treatments to manage HPV+ OPC patients are effective but not without limitations and, therefore, there remains an urgent need to develop more active and less toxic drugs to optimally manage these patients in the first-line and recurrent/metastatic settings. Our multi-disciplinary team developed a novel, dual p53 and p300 modulator to reactivate tumor suppressive programs in HPV+ OPC. This proposal will provide new insights on the biological consequences of restoring p53 and p300 functionality, and results generated will be leveraged to guide the drug development path of OHM1.

PI_NAMEs: PAN, QUINTIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acetylation;Anatomy;anti-cancer;anti-PD1 antibodies;anti-PD1 therapy;anticancer activity;Antitumor Response;Apoptosis;Binding;Biological;Biological Markers;Biological Process;CD8-Positive T-Lymphocytes;Cell Cycle Arrest;Cell Line;Cell Physiology;Chemicals;ChIP-seq;Chromatin;Cisplatin;Code;Collaborations;Collection;Combined Modality Therapy;Complex;Data;Disease;drug development;drug discovery;EP300 gene;Etiology;Event;Gene Dosage;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Human;human papilloma virus oncogene;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;immune cell infiltrate;immune checkpoint blockade;Immunotherapy;In Vitro;in vivo;Incidence;Infiltration;insight;Lead;Ligands;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Metastatic/Recurrent;Methylation;Modality;Modeling;Morbidity - disease rate;multidisciplinary;Mus;novel;novel strategies;Nuclear;Oncogenes;oral HPV-positive head and neck cancers;Oropharyngeal Squamous Cell Carcinoma;Pathway interactions;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Population;Post-Translational Protein Processing;pre-clinical;programmed cell death ligand 1;programmed cell death protein 1;programs;promoter;protein complex;Quality of life;recruit;Regulatory Element;research and development;response;senescence;Shapes;Site;stressor;Therapeutic;tool;TP53 gene;treatment response;trend;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;UBE3A gene;Ubiquitination;Work

PROJECT_TITLE: Dual p300 and p53 reactivation in HPV+ head and neck cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: MICROBIOME Conference October 29 – November 2, 2024  PROJECT NARRATIVE Scientific studies have transformed our concept of microbes (bacteria, fungi, viruses, archaea). Whereas we used to conceive of most microbes as disease-causing enemies, we now understand that microbes are essential for promoting health and might also contribute to ameliorating disease. A growing body of research seeks to uncover how microbes interact with each other in multispecies communities and cohabitate with their multicellular human hosts. If we better understand how microbial communities interact, through modeling these interactions and dissecting the mechanisms at this interface, we will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease. The fourth installment of the Microbiome conference will focus on the latest approaches to study and treat the wide-range of microbial associated diseases, integrating the disciplines of clinical research, microbiology, immunology, ecology, bioinformatics and genomics. The integration of a wide variety of disciplines will promote new interactions seldom achieved at other microbiome meetings. This meeting will have a specific focus on young investigators and trainees to facilitate the scientific interactions necessary to grow this field and develop novel clinical and experimental approaches, diagnostics and therapies.

PI_NAMEs: STEWART, DAVID J. (contact)

PROJECT_TITLE: CSHL 2024 Microbiome Conference


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Obesity

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: In persons with diabetes and obesity, multiple factors converge to mediate maladaptive responses to respiratory viruses, such as SARS-CoV2 (COVID-19) and influenza (flu), resulting in greater disease severity and higher mortality. In the lungs, impaired viral clearance and exaggerated inflammatory responses increase lung damage and suppress resolution and repair. Delineation of the mechanisms mediating impaired host responses to respiratory viruses in diabetes and obesity is essential to identify new therapeutic targets.

PI_NAMEs: KHANNA, KAMAL MOHAN (contact);SCHMIDT, ANN MARIE

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: 2019-nCoV;Address;Adipocytes;Adipose tissue;Affect;Alveolar Macrophages;Animals;Anti-viral Response;ATAC-seq;Atherosclerosis;Body Weight decreased;Bone Marrow;Bone Marrow Transplantation;Catabolism;Cells;Cellular Metabolic Process;conditioning;Confocal Microscopy;COVID-19 severity;Crowns;cytokine;Data;Diabetes Mellitus;Environment;Epidemic;Fat-Restricted Diet;Flow Cytometry;flu;Genes;High Fat Diet;Human;human disease;Hydrolase;Hyperglycemia;IL6 gene;Image;Immune;Immune response;Immunity;Immunology;Impairment;improved;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;innate immune mechanisms;Interleukin-1 beta;Interleukin-9;Invaded;ITGAX gene;Laboratories;Link;lipid metabolism;Lipids;Lipoprotein (a);Lung;lung injury;Macrophage;Mediating;Metabolism;Methodology;Methods;Microbiology;mortality;mouse model;Mus;Myelogenous;neuroinflammation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;Outcome;Oxidative Stress;Pathogenicity;Persons;Phospholipids;PLA2G6 gene;Platelet Activating Factor;prevent;Production;programs;recruit;repaired;Reporting;Resolution;respiratory virus;response;RNA;Role;SARS-CoV-2 infection;Severities;Severity of illness;single-cell RNA sequencing;Sorting;Stress;Structure;Structure of parenchyma of lung;Techniques;Testing;Thinness;Tissues;TNF gene;Training;transcriptome sequencing;transcriptomics;Up-Regulation;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Weight Gain;Work

PROJECT_TITLE: Effect of obesity and diabetes in regulating pulmonary and extra-pulmonary anti-viral immune responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-L (02)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Public health narrative The bile ducts are microscopic and large tube-like structures that carry bile. Many bile duct diseases are associated with the loss of these bile ducts resulting in chronic liver disease. Currently, there is no cure or clinical treatment to augment the number or architecture of bile ducts. Our work suggests that bile duct-stroma crosstalk guides and patterns cell type specification, bile duct formation, and response to injury. Leveraging several novel tools that we have developed we aim to identify the role and underlying components of bile duct cell-stroma crosstalk and their impact on bile duct loss and biology.

PI_NAMEs: HUPPERT, STACEY S;SCHWARTZ, ROBERT E (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Address;Adult;Affinity;Agonist;Alagille Syndrome;alpha 1-Antitrypsin Deficiency;Architecture;bile acid transporter;Bile Acids;Bile Acids and Salts;bile duct;Bile Duct Diseases;Bile fluid;Biliary;Biliary Atresia;Binding;Biology;cell stroma;cell type;Cells;cholangiocyte;Cholestasis;Chronic;chronic liver disease;Clinical;Clinical Treatment;Consensus;Data;Development;Disease;DNA Binding;Duct (organ) structure;Enterohepatic Circulation;Epithelium;Erinaceidae;Etiology;Family member;Fibrosis;Foundations;Future;Genes;Genetic;Genetic Transcription;Glioma;Goals;healing;Hepatic;Hepatic Stellate Cell;Hepatocyte;Homeostasis;Human;improved;In Vitro;in vivo;Injury;Interruption;intrahepatic;Intrahepatic bile duct;Knowledge;Ligands;Liver;liver transplantation;Maintenance;Mediating;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Microscopic;Molecular;Morphogenesis;Mus;Nomenclature;notch protein;novel;novel strategies;Oncogenes;Operative Surgical Procedures;Organ;Pathologic;Patients;Pattern;Phenotype;Play;Population;potential biomarker;Primary biliary cirrhosis;primary sclerosing cholangitis;Process;programs;Progressive intrahepatic cholestasis;Public Health;Publishing;Regulation;repaired;Research;response to injury;Role;Shapes;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;Specific qualifier value;standard of care;Structure;System;targeted treatment;Testing;Therapeutic;Time;tool;transcription factor;transdifferentiation;Tube;Work

PROJECT_TITLE: Mechanisms of epithelial-mesenchymal crosstalk in intrahepatic biliary formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Palliative Care

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Informal caregiving for persons living with dementia (PLWD) is uniquely demanding and the rapid aging of the U.S. population drives a growing gap between the demand for and supply of informal caregivers. The proposed study will uniquely utilize longitudinal, nationally representative surveys and advanced causal inference methodologies to examine the impact of: 1) informal caregiving on health care use of both PLWD and their caregivers; 2) caregiver serious illness (i.e., hospitalization for pneumonia, heart attack, stroke, and hip fracture) on health care use of PLWD; and 3) PLWD serious illness on health care use of caregivers. Understanding the reciprocal impacts of informal caregiving and serious illness on health care use of both PLWD and caregivers will help identify high-risk PLWD and caregivers to inform targeted interventions to maintain the optimal health and wellbeing of both PLWD and caregivers.

PI_NAMEs: LEI, LIANLIAN  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Adverse effects;Affect;Age;Aging;Alzheimer's Disease;Applications Grants;Area;Attention;Award;Behavior;care outcomes;career;caregiver interventions;Caregivers;caregiving;Caring;Chronic;Clinical;Complex;Contracts;cost;Data;Data Analytics;Daughter;Dementia;Dementia caregivers;Deterioration;Disease;Econometric Models;Economics;Emergency department visit;Emotional;experience;Exposure to;Family member;Foundations;Friends;functional decline;Funding;Future;Gatekeeping;Geriatric Psychiatry;Goals;Health;Health and Retirement Study;health care service utilization;Health Promotion;Health Services;Health Services Research;Health Status;Healthcare;Healthcare Systems;high risk;high risk population;Hip Fractures;Hospitalization;Hour;Impaired cognition;Impairment;informal care;informal caregiver;informal caregiving;innovation;Intervention;Knowledge;Leadership;Light;Link;Long-Term Care;Longitudinal Surveys;Marketing;Medical;Medicare;Medicare claim;member;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality risk;Myocardial Infarction;older adult;Outcome;Outpatients;Pathway interactions;Personal Satisfaction;Persons;Phase;Pneumonia;Policies;Population;pressure;Professional Competence;programs;Public Health;Research;Research Personnel;Self Care;Shock;skills;Solid;Source;Spouses;Stroke;Surveys;Training;trend;Visit;Wife;Work

PROJECT_TITLE: Older Adults Living with Dementia and Their Informal Caregivers: Reciprocal Impacts of Caregiving and Serious Illness on Health Care Outcomes


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Relevance to public health: Aspergillus fumigatus, a major human fungal pathogen and leading cause of invasive aspergillosis, can infect a wide variety of immunocompromised individuals and represents a significant threat to global public health. This application will determine how translational efficiency mechanisms control conidial germination, an important virulence property of A. fumigatus. Ultimately, this study will provide a better understanding of global translational regulatory circuits and pathways that regulate A. fumigatus conidial germination as well as identify and characterize several key factors important for this process that could potentially serve as targets for the development of novel and more effective antifungal strategies.

PI_NAMEs: KADOSH, DAVID  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 1 year old;5' Untranslated Regions;Acute leukemia;Air;Allergic Bronchopulmonary Aspergillosis;Angioinvasion;anti-fungal agents;asexual;Aspergillosis;Aspergillus;Aspergillus fumigatus;Bioinformatics;Blood Circulation;Cancer Patient;Candida albicans;Cause of Death;comparative;Cycloheximide;Death Rate;Defect;Development;Disease;DNA biosynthesis;Environment;Event;Filament;fungus;Genes;Genetic Transcription;genome-wide;Germination;Goals;Growth;Health Care Costs;Human;Hyphae;Immunocompromised Host;Individual;Infection;Inhalation;inhibitor;Invaded;Laboratories;Link;Lung;Measurable;Mediating;Morphology;Mycoses;new therapeutic target;novel;organ transplant recipient;overexpression;Pathogenesis;pathogenic fungus;Pathway interactions;Patients;Penetration;Phenotype;Play;prevent;Process;Property;Protein Biosynthesis;protein expression;Protein Synthesis Inhibitors;Proteins;Proteomics;Public Health;Pulmonary alveolar structure;Reproduction spores;ribosome profiling;RNA Binding;RNA chemical synthesis;RNA, Messenger, Stored;Role;Sepsis;Signal Induction;Signal Pathway;Site;Soil;Stem cell transplant;stress tolerance;Structure of parenchyma of lung;Swelling;Testing;Transcript;Transcriptional Regulation;transcriptomics;Translational Regulation;Translations;Transplant Recipients;Travel;Virulence;whole genome;Work;Yeasts

PROJECT_TITLE: Translational Control of Conidial Germination in Aspergillus fumigatus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-D (02)]


ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE. Epidemiological studies show that the risk of atherogenic cardiovascular disease increases with age and, in the case of women, post-menopause. In this application we propose to dissect the impact of age, sex, and hormonal status on the development of atherogenic disease in hyperlipidemic mice. We also propose to test the idea that promoting the resolution of inflammation by inducing regulatory T-cells is atheroprotective.

PI_NAMEs: AURORA, RAJEEV ;BALDAN, ANGEL  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Advocate;Affect;Age;age effect;age related;aged;Aging;Animals;Anti-Inflammatory Agents;Aorta;aortic arch;Arteries;atherogenesis;atheroprotective;Atherosclerosis;Attention;Bioinformatics;Biological Markers;blood lipid;Blood Vessels;cardioprotection;Cardiovascular Diseases;cardiovascular risk factor;Cause of Death;CD8B1 gene;Cell Communication;Cell secretion;Cells;Cholesterol;Clinical;comorbidity;CTLA4 gene;Data;data integration;Data Set;design;Development;Diagnostic;Disease;Dose;efficacy evaluation;efficacy testing;Elderly;Endothelial Cells;Environment;epidemiology study;Estrogens;Estrus;Event;exhaust;extend lifespan;Female;Foundations;FOXP3 gene;Functional disorder;Future;Goals;Growth;Health Care Costs;healthcare burden;High Risk Woman;Hormonal;Human;human female;hypercholesterolemia;Hyperlipidemia;IL2RA gene;Immune Tolerance;improved;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;insight;Interleukin-10;Intervention;Knowledge;Laboratories;LDL Cholesterol Lipoproteins;Lead;Left;Lesion;life span;Life Style;Link;Lipids;Longevity;Macrophage;male;Maps;Mediating;Mediator;men;Menopause;Modern Medicine;Molecular;mortality;mouse model;Mus;novel;novel strategies;novel therapeutics;old mice;older men;older women;Outcome;Outcome Study;Ovarian hormone;Ovariectomy;Pathology;Pathway interactions;Patients;Persons;Physiologic pulse;Physiological;Physiology;Play;Population;Postmenopause;Predisposition;Preparation;Production;Protein Secretion;Publishing;Quality of life;Randomized;recruit;Recurrence;Regulatory T-Lymphocyte;reproductive;Resolution;Risk;Role;Rupture;segregation;Serum Markers;Severity of illness;sex;sham surgery;single-cell RNA sequencing;Smooth Muscle Myocytes;Structure of subclavian artery;T-Lymphocyte;Testing;Therapeutic;TNFSF11 gene;tool;Transcript;transcriptomics;translational potential;western diet;Woman;Work

PROJECT_TITLE: Age, sex, hormonal status, and anti-inflammatory therapy for atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-F (02)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Wheelchairs give Veterans with paralysis due to spinal cord injury (SCI) freedom to move and better quality of life. Sadly, Veterans using wheelchairs can be injured if they cannot feel or move if their leg or foot falls off or sits wrongly on the wheelchair foot rest. Injuries have included broken legs, pressure ulcers, such bad scrapes that a Veteran’s leg had to be cut off, and one Veteran may have died from severe bleeding due to this while on blood thinners. In this study, we will work with Veterans with SCI, their caregivers and seating therapists to understand how these foot displacements occur and when they become clinically significant. We will use our FootSafe foot pressure and position sensor along with motion capture technology to learn if Veterans with spinal cord injury have more uncontrolled movements of their legs and feet while using wheelchairs compared to people using wheelchairs for other reasons, like bad arthritis. We will also use artificial intelligence to better understand the limb movement data to see if there are early warning signs that the limb will become displaced.

PI_NAMEs: BOGIE, KATH ;HENZEL, MARY K (contact)

PROJECT_TERMS: 3-Dimensional;Admission activity;Advocate;algorithm development;Algorithms;Amputation;Anticoagulants;Arthritis;Artificial Intelligence;Automobile Driving;Back;Biomechanics;care costs;care systems;Caregivers;Caring;Classification;clinically relevant;clinically significant;Communities;community setting;Consensus;Contracture;Contusions;cost;Dangerousness;Data;Data Set;decubitus ulcer;design;Detection;detection method;detection sensitivity;Development;Disease;Documentation;empowerment;Equipment Malfunction;Evaluation;Event;falls;Focus Groups;foot;Foot Plate;Fracture;Freedom;Future;Guidelines;Health Technology;healthy volunteer;Hemorrhage;Impairment;improved;Incidence;injured;Injury;Inpatients;Intervention;kinematics;Knowledge;Laboratories;Learning;Leg;Legal patent;limb injury;limb movement;Limb structure;Literature;Lower Extremity;Machine Learning;Medical Records;mHealth;Mobility decline;Modernization;Modification;Motion;Movement;multimodality;Nervous System Disorder;Neurologic;Obesity;operation;Paralysed;Peripheral Nervous System Diseases;Persons;Phase;Population;Positioning Attribute;Powered wheelchair;Predisposition;pressure;Prevalence;prevent;Prevention;Process;prototype;Quality of life;real time monitoring;Reporting;Research Project Grants;Rest;Risk;Running;Safety;Self-Help Devices;sensor;Sensory;sensory feedback;smart device;Spasm;spasticity;Specialist;Speed;Spinal cord injury;Stroke;Surveys;System;Technology;Testing;Time;time use;Veterans;Wheelchair user;Wheelchairs;wireless;Work

PROJECT_TITLE: Toward understanding mechanisms of inadvertent lower extremity displacements from wheelchair footplates in Veterans with SCI/D: Multi-modal evaluation of leg movements during power wheelchair use.

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Parasitic helminths affect billions of people worldwide and many of the most common helminths passage through the lung as part of their developmental cycle. While alveolar macrophages (AMs) are known to play important antihelminth roles, the molecular pathways that instruct AM activation remain unknown. This proposal will investigate how the enzyme carbonic anhydrase 4 (Car4) regulates the M2 activation of AMs and thereby regulates helminth-induced lung inflammation and firbosis.

PI_NAMEs: SIRACUSA, MARK CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Affect;Alveolar Macrophages;Bioenergetics;Carbon Dioxide;carbonate dehydratase;Carbonic Anhydrase IV;Cells;Child;Chronic;combat;cytokine;Data;Development;Endothelial Cells;Enzymes;Equilibrium;Event;Exhibits;Family;Fibrosis;Genes;Growth;helminth infection;Helminths;Homeostasis;Hookworms;Hypoxia;Hypoxia Inducible Factor;Immune;immune activation;Immunity;immunopathology;immunoregulation;Individual;Infection;Inflammation;Inflammatory Response;insight;ITGAX gene;Lipid A;lipid metabolism;LoxP-flanked allele;Lung;Lung Diseases;lung injury;Macrophage;Macrophage Activation;Malnutrition;Mediating;Metabolic;Metabolism;migration;Molecular;Monitor;monocyte;Mus;new therapeutic target;Nippostrongylus;novel;novel therapeutic intervention;Oxygen;Parasitic infection;Pathology;Pathway interactions;Persons;Phenotype;Play;Prevalence;prevent;Publishing;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;recruit;Reporting;response;Role;sensor;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;Testing;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Car4 regulates M2 macrophage responses and host protection to helminths

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The treatment of solid tumors, including lung cancer, with platinum-based anticancer drugs (e.g., cisplatin) often results in the development of resistance, leading to therapeutic failure, but the mechanisms by which cellular and metabolic signaling coordinately lead the resistance remain unclear. In this proposal, we will uncover how microtubule-associated serine/threonine kinase 1 (MAST1) is activated (by AURKB) and induced (by p53- CEBPb) and how it manages metabolism to drive platinum resistance in human cancers. We will also validate the therapeutic efficacy of a new combination of targeting MAST1 signaling (lestaurtinib) and parallel receptor tyrosine kinase signaling (ponatinib) to enhance platinum-based therapy outcomes.

PI_NAMEs: KANG, SUMIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: anti-cancer;Antineoplastic Agents;aurora B kinase;Binding;Biological Assay;blood glucose regulation;c-myc Genes;cancer cell;Cancer Patient;cancer therapy;Cell Survival;Cells;Chemoresistance;Cisplatin;Clinical;combinatorial;Data;Databases;drug repurposing;Equilibrium;Exposure to;Failure;Gene Expression;gene induction;Genetic Transcription;Glucose;glucose uptake;Glycolysis;Growth;Head and Neck Cancer;Human;inhibitor;kinase inhibitor;Lead;Link;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;MAP Kinase Gene;MAP2K1 gene;Mediating;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Microtubules;Molecular;mouse model;Mus;mutant;Mutation;Mutation Analysis;Oncogenic;Organ;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;patient subsets;Patients;peroxiredoxin 2;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Platinum;Platinum Compounds;Play;predictive marker;Primary Neoplasm;Prognosis;Property;Protein-Serine-Threonine Kinases;Proteomics;Receptor Protein-Tyrosine Kinases;refractory cancer;Regimen;Regulation;Resistance;Resistance development;response;RNA interference screen;Role;Series;Serine;Signal Transduction;SLC2A1 gene;Solid Neoplasm;synergism;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;Time;Toxic effect;TP53 gene;transcription factor;Treatment Efficacy;tumor growth;tumor metabolism;upstream kinase

PROJECT_TITLE: Dissecting and Targeting MAST1 Signaling in chemoresistant Cancers

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Promoting axon regeneration remains an important strategy in order to identify effective restorative treatment for spinal cord injury. This proposal will using a cutting-edge experimental approach, Patch-seq, to better understand the neuron intrinsic control of regenerative process. New insights gained will be valuable in designing therapies to promote repair and recovery after spinal cord injury.

PI_NAMEs: ZHENG, BINHAI  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Age;age effect;age group;age related decline;Antioxidants;Area;Axon;axon growth;axon regeneration;Biogenesis;Bioinformatics;Biological Markers;Biological Process;Biology;Brain;Cells;Central Nervous System;Clinical;clinical translation;Corticospinal Tracts;Data Set;Dedications;deep sequencing;demographics;Dissociation;Electric Stimulation;Electrophysiology (science);Exhibits;experience;experimental study;Fluorescence-Activated Cell Sorting;Foundations;Funding;gain of function;Genes;Genetic;Genetic Transcription;Genomic approach;Human;improved;in vivo;Injury;insight;Investigation;Link;loss of function;microscopic imaging;Mitochondria;Molecular;Morphology;multimodal data;Natural regeneration;neural repair;Neurons;Paper;Paralysed;patch sequencing;Persons;pre-clinical;Process;Recovery;regeneration potential;regenerative;regenerative biology;Regenerative research;regenerative therapy;Regulation;repaired;Research;Research Personnel;Resistance;response;restorative treatment;Retinal Ganglion Cells;Rodent;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;Spinal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;spinal cord regeneration;Spinal Ganglia;success;System;Technology;therapeutic development;therapy design;therapy development;Training;transcriptomics;Translations;United States;Validation;web portal

PROJECT_TITLE: Patch-based deep scRNA-Seq to understand axon repair in the mammalian spinal cord

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative We aim to study bacterial communication by extracellular vesicles (EVs), which are cell-to-cell mailing system that enables sophisticated intracellular communication within and across the eukaryotic and prokaryotic domains. Our long-term goal is to generate a comprehensive understanding of the bacterial EV-mediated communications across bacterial and host populations, elucidate the underlying molecular mechanisms mediating these communications, and describe the functional consequences of bacterial EV action on target cells. This proposal build on our finding that pneumococcal EVs are associated with nucleic acids, and is designed to reveal the molecules that tether nucleic acids to the pEV surface, to characterize the nature of pEV RNA, establish pEV uptake into bacterial cells, and explore their impact on bacterial gene expression.

PI_NAMEs: HILLER, NATALIA LUISA (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Anti-Inflammatory Agents;Automobile Driving;Bacteria;Bacterial Genes;Bacterial Physiology;Bacterial RNA;Binding;Cell Communication;Cell membrane;Cell Wall;Cells;Communication;Complement;Confocal Microscopy;Data;design;DNA;Environment;experimental study;extracellular;extracellular vesicles;Flow Cytometry;frontier;Future;Gene Expression;Gene Expression Profile;Glycolipids;Glycoproteins;glycosylation;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;human pathogen;Immobilization;Immune response;Immunity;Infection;insight;Kinetics;Label;Linker DNA;Lipid Binding;Lipids;Macrophage;Maps;Mediating;Membrane;Messenger RNA;Metabolic;Microscopy;Molecular;Morbidity - disease rate;mortality;Nature;neutrophil;Nucleic Acid Binding;Nucleic Acids;Output;Pathogenesis;Peptide Hydrolases;Phenotype;Population;Process;protein crosslink;Proteins;response;RNA;RNA Binding;Role;Route;Secure;Signal Transduction;Streptococcus pneumoniae;Surface;System;targeted treatment;Testing;therapeutic target;therapy development;Thick;Time;Untranslated RNA;uptake;Virulence;Visualization;Work

PROJECT_TITLE: Nucleic Acids and Pneumococcal Extracellular Vesicles: the Who, How and Why?

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);Genetics;Opioid Misuse and Addiction;Opioids;Pediatric;Prescription Drug Misuse;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: WASHINGTON UNIVERSITY

PHR: We will examine the association between early onset cannabis use and opioid involvement, including OUD, in a variety of datasets, and estimate the extent to which shared genetic factors, and adverse childhood experiences contribute to their association. We also examine the role of co-occurring stimulant misuse, a common occurrence in overdoses and a strong correlate of early cannabis use. As cannabis use continues to become more accepted, understanding whether early use of cannabis motivates progression to OUD, which is contributing to the overdose epidemic, is of critical public health importance.

PI_NAMEs: AGRAWAL, ARPANA  (contact);NELSON, ELLIOT C

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adult;adverse childhood events;Age;Age of Onset;Animal Experiments;Architecture;Attention;Behavioral;biobank;Cannabinoids;Cannabis;clinical practice;Cocaine;cocaine use;comorbidity;COVID-19 pandemic;Data;Data Analyses;Data Set;Development;Diagnosis;Disease;Distal;early life adversity;early onset;Epidemic;Epidemiology;Epigenetic Process;Etiology;experimental study;externalizing behavior;Future;Genetic;Genetic Predisposition to Disease;genetic variant;Genomics;Human;Illicit Drugs;indexing;Individual;insight;Intervention;Legal;Longitudinal Studies;marijuana use;Measurement;Measures;Mental disorders;Molecular;Morbidity - disease rate;mortality;non-genetic;Normalcy;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid use disorder;Overdose;overdose death;Pathway interactions;peer;Pharmaceutical Preparations;Phenotype;phenotypic data;preclinical study;Predisposition;Premature Mortality;Prevalence;psychosocial;psychostimulant;Public Health;public health priorities;Recreation;Relapse;Reporting;Research;Residual state;response;Rodent;Role;Sampling;Self Administration;Severities;Siblings;Stimulant;stimulant misuse;stimulant use;substance use;Substance Use Disorder;Testing;Tetrahydrocannabinol;trend;Twin Multiple Birth;vigilance;Withdrawal;Youth

PROJECT_TITLE: Early cannabis use and later opioid use disorder - the role of adverse childhood experiences, genetic liability and comorbid stimulant use

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ORG_CITY: Rockville

ORG_NAME: SOCIETY FOR DEVELOPMENTAL BIOLOGY

PHR: Cho, Ken PROJECT NARRATIVE The Annual Meetings of the Society for Developmental Biology are the major yearly event where top developmental biologists and trainees gather to discuss recent scientific advancements and offer educational training for new PIs, postdoctoral fellows and students. These meetings explore the mechanisms that guide the normal development of organisms post-fertilization and the outcomes when these mechanisms go awry. Unlike other meetings focused on specific organisms or diseases, the SDB annual meetings offer an integrated perspective on development, attracting researchers using various organisms and technologies.

PI_NAMEs: CHO, KEN W.Y. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Active Learning;Adoption;Aging;Agriculture;Amaze;Area;Atmosphere;career;Collaborations;Communication;Communities;Computational Science;Dedications;Development;Developmental Biology;Disease;diversity and inclusion;Embryonic Development;Ethics;Event;Fertilization;Fostering;Geographic Locations;graduate student;Human;Individual;Inequality;interest;Knowledge;mathematical sciences;meetings;member;Mission;Organism;Organogenesis;Organoids;Outcome;Participant;physical science;Planarians;Plants;Postdoctoral Fellow;Principal Investigator;Process;programs;Regenerative Medicine;Reproduction;reproductive;Research Personnel;science education;Science Policy;science, technology, engineering, mathematics, and medicine;Scientific Advances and Accomplishments;Scientist;social;Societies;sound;Students;Technology;Totipotent cell;Training and Education;undergraduate student

PROJECT_TITLE: Society for Developmental Biology Annual Meetings 2024-2028

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Down Syndrome;Hematology;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Children with Down syndrome (DS) have a higher burden of many co-occurring conditions including 1) structural birth defects, which are associated with significant morbidity and mortality; 2) abnormal hematopoiesis, which includes a 20-fold increased risk of acute leukemia; and 3) neurodevelopmental disorders, which significantly impact functional independence and quality of life. Important gaps in knowledge limit health supervision guidelines and targets for intervention. In this application, we seek to address these gaps by leveraging the Texas Birth Defects Registry, one of the world’s largest and most diverse population-based active birth defects surveillance systems, to develop the Down syndrome Early Childhood Omics, Deep phenotyping, and Epidemiology In Texas: DECODE IT Cohort to include >1,000 children with DS, representing a diverse population historically excluded from DS research.

PI_NAMEs: AGOPIAN, A.J. ;JACOLA, LISA M;LUPO, PHILIP  (contact);RABIN, KAREN R;RASMUSSEN, SONJA ANN

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Acute leukemia;Address;biobank;Biological Markers;Birth;Birth Records;Blood Screening;Child;Clinical;cohort;Collaborations;Collection;college;community engagement;Congenital Abnormality;Development;Down's Syndrome;early childhood;Electronic Health Record;Eligibility Determination;Enrollment;Epidemiology;Ethnic Origin;Exclusion;experience;Foundations;functional independence;Genetic;Genomics;Geographic Locations;Geography;Goals;Guidelines;Health;Hematopoiesis;Hematopoietic;Hybrids;improved;improved outcome;Individual;Infant;inter-individual variation;Intervention;Knowledge;leukemia;Life;Medical Records;Medicine;Monitor;Morbidity - disease rate;mortality;Natural History;Neonatal Screening;neurodevelopment;Neurodevelopmental Disorder;Newborn Infant;novel;Outcome;Persons;Phenotype;population based;Population Heterogeneity;Prevalence;Prevention;Procedures;prospective;Protocols documentation;Public Health Schools;Quality of life;recruit;Registries;Research;Resources;response;Risk;Saint Jude Children's Research Hospital;Sample Size;Sampling;Site;Source;Spottings;Structural Congenital Anomalies;Supervision;Surveillance Program;Syndrome;System;Texas;Training;Underrepresented Minority;virtual assessment;Whole Blood;Work

PROJECT_TITLE: Down Syndrome Early Childhood Omics, Deep Phenotyping, and Epidemiology in Texas: DECODE IT Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (55)]