NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Autism spectrum disorder (ASD) is caused by both environmental and genetic factors, but most of the genes responsible for ASD remain unknown, and the functions of most ASD risk genes that have been identified are poorly understood. We will use zebrafish as a vertebrate model system to study the effects of a large number of recently-identified ASD risk genes on brain development and behavior. These studies will improve our understanding of why mutations in specific genes result in ASD and may ultimately lead to novel therapies.

PI_NAMEs: GESCHWIND, DANIEL H;PROBER, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acceleration;Address;Animal Model;autism spectrum disorder;Autopsy;Behavior;behavior test;Behavioral;Behavioral Model;behavioral phenotyping;Biological Assay;Biological Models;Brain;Cells;cohort;Communities;comorbidity;cost;cost effectiveness;Data;data integration;de novo mutation;Development;Disease;disease model;disorder risk;Drug Screening;experimental study;Gene Expression;gene function;gene network;Genes;Genetic;genetic risk factor;genome sequencing;genome wide association study;genome-wide;Goals;habituation;high throughput analysis;high throughput screening;high-throughput drug screening;Human;Image;imaging approach;improved;in vivo;Individual;Inherited;Literature;Methods;Missense Mutation;model of autism spectrum disorder;model organism;Modeling;Molecular;molecular phenotype;mutant;Mutation;neurodevelopment;Neurons;novel;novel therapeutic intervention;novel therapeutics;null mutation;Orthologous Gene;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Protein Truncation;Publishing;Reagent;relative effectiveness;Reporting;Resources;Risk;risk variant;RNA Splicing;Role;screening;Seizures;Signal Transduction;Sleep;Sleep disturbances;social;Social Behavior;Spliced Genes;Startle Reaction;System;Testing;Time;Tissue-Specific Gene Expression;transcriptomic profiling;transcriptomics;Translating;translational goal;Variant;Vertebrates;whole genome;Zebrafish

PROJECT_TITLE: High-throughput modeling of autism risk genes using zebrafish

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Twenty-nine faculty affiliated with the Visual Sciences Research Center (VSRC) at Case Western Reserve Uni- versity (CWRU) seek renewed support for the Visual Sciences Training Program (VSTP). This T32 Institutional Training Grant renewal application is organized according to a Visual Sciences Community representing four major vision science research themes: (a) Retinal Development and Function; (b) Retinal Disorders: Diabetic Retinopathy (DR) and Age-related Macular Degeneration (AMD); (c) Biochemistry, Cell Biology, Immunology of Eye Diseases; and (d) Genetics, Physiology, and Epidemiology of Eye Diseases. Continued support is re- quested for four predoctoral positions and one postdoctoral position in all years.

PI_NAMEs: VON LINTIG, JOHANNES FRIEDRICH (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: CWRU-Visual Sciences Training Program


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The limited efficacy of current therapies in metastatic patients argues that we do not fully understand metastasis. The metastatic capacity of prostate cancer (PCa) behaves along a spectrum of disease that contains an oligometastatic state where metastases are limited in number and location. The ROBIN OligoMET Center will test the global hypothesis that consolidative radiation can alter cancer cell state plasticity and host-tumor metabolism that drives metastasis formation.

PI_NAMEs: SAWANT, AMIT ;SIMONE, NICOLE L;TRAN, PHUOC T. (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Affect;African American;Baltimore;Biological Models;Biology;cancer cell;candidate identification;Caucasians;Cells;Clinical Data;Clinical Trials;clinically relevant;combat;Complex;Computing Methodologies;Data;Data Analyses;Deposition;design;Development;Disease;Disparity;Disseminated Malignant Neoplasm;Distant;DNA;Ensure;Evaluation;experience;Faculty;Failure;first-in-human;Funding;genomic profiling;Genomics;Grant;Human;Image Analysis;Immune;Immune Evasion;Immune response;in vivo;innovation;Institution;Intervention;Invaded;Joints;Leadership;liquid biopsy;Liquid substance;Location;Malignant neoplasm of prostate;Maryland;Medicine;Metabolic;Metabolism;metabolomics;metastatic process;Methods;Microscopic;Modeling;Molecular;mouse model;multidisciplinary;multiple omics;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutics;Organ;Organism;Pathway Analysis;Patients;Pattern;Phase;Physics;Plasma;Progression-Free Survivals;Proteomics;quantitative imaging;Radiation;Radiation Oncology;Radiation therapy;Radiobiology;radiomics;Randomized;randomized trial;Recording of previous events;Recurrence;Research;Research Project Grants;Resource Sharing;RNA;Sampling;System;Techniques;Testing;Time;Tissues;Training;tumor;tumor behavior;Tumor Immunity;tumor metabolism;tumor microenvironment;Universities;Validation

PROJECT_TITLE: Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET) Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Radiation Oncology;Urologic Diseases

PI_NAMEs: TRAN, PHUOC T. (contact)

PROJECT_TERMS: Advisory Committees;Advocate;Affect;anti-cancer research;Applications Grants;Basic Science;Biology;cancer site;career;Clinical Trials;clinically relevant;Collaborations;Collection;Committee Members;Communication;Communities;Computing Methodologies;Data;Disparity;Doctor of Medicine;Doctor of Philosophy;Ensure;experience;Faculty;Financial Support;Funding;Genomics;Goals;Grant;improved;Infrastructure;innovation;International;Laboratories;Leadership;liquid biopsy;Malignant neoplasm of prostate;Maryland;medical schools;Medicine;meetings;Mentors;metabolomics;metastatic process;Mission;Molecular;multidisciplinary;Neoplasm Metastasis;next generation;Normal tissue morphology;Occupational activity of managing finances;Oncology;outreach;Pathology;Patient-Focused Outcomes;Patients;Peer Review;Productivity;professor;programs;Radiation;radiation countermeasure;Radiation Oncologist;Radiation Oncology;Radiation therapy;Radiobiology;radiomics;Research;Research Contracts;Research Project Grants;Resources;Science;Site Visit;symposium;Techniques;tissue injury;Training;United States National Institutes of Health;Universities;Validation;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Radiation Oncology;Urologic Diseases

PROJECT_TERMS: Address;Baltimore;Biological Assay;Biological Markers;Biology;Castrate sensitive prostate cancer;Cessation of life;circulating biomarkers;Clinical;Clinical Data;Correlative Study;Data;Deposition;Disease;Distant Metastasis;Electromagnetic Energy;experimental study;Failure;first-in-human;FOLH1 gene;Future;Genetic Transcription;genomic profiling;Growth;Image;imaging biomarker;Immune response;innovation;liquid biopsy;Liquid substance;Location;Malignant neoplasm of prostate;men;metabolomics;metastatic process;Metastatic Prostate Cancer;Methods;microbiome;Microscopic;Molecular;Monitor;Mutation;Neoplasm Metastasis;novel;patient population;Patients;Pattern;Peripheral;PET/CT scan;Phase;Plasma;predictive marker;prognostic;programs;Progression-Free Survivals;Prostate;Prostatic Neoplasms;Proteomics;Radiation;Radiation Dose Unit;Radiation Oncology;Radiobiology;radiomics;Randomized;randomized trial;Recurrence;Research Design;Resources;response;response biomarker;Systemic Therapy;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;tissue biomarkers;Tissues;transcriptome sequencing;treatment response;trend;tumor;X-Ray Computed Tomography

PROJECT_TITLE: Phase 2 randomized Total Eradication of metastatic lesions following definitive Radiation to the Prostate in de novo oligometaStatic prostate cancer (TERPS) trial


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our vision is to advance PNA5 as a first-in-class therapy to reduce inflammatory-disease related cognitive impairment in patients at risk for Alzheimer’s Disease and Related Dementias (ADRD) and Vascular Contributions to Cognitive Impairment and Dementia (VCID). With the completion of this project we will obtain the protocols and necessary documentation to amend our IND for our peptide to begin Phase 2 clinical trials to treat cognitive impairment in patients as risk for developing ADRD and VCID.

PI_NAMEs: HAY, MEREDITH  (contact);VANDERAH, TODD W

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acceleration;Agonist;AGTR2 gene;Alzheimer's disease related dementia;Alzheimer's disease risk;Amendment;angiotensin I (1-7);Anti-Inflammatory Agents;aqueous;Arizona;Australia;Award;Binding;Biological Availability;Biological Markers;Brain;cardiovascular risk factor;cerebrovascular;Cerebrovascular Circulation;Cerebrum;China;Chronic;Clinical;Clinical Protocols;Clinical Research;Clinical Trials Design;Cognitive;cognitive function;Data;Dementia;Development;Diagnosis;Disease;Documentation;Dose;Drug Industry;Drug Kinetics;Europe;Exhibits;experience;first-in-human;Formulation;Glycopeptides;glycosylation;Goals;GTP-Binding Proteins;Human;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Japan;Kilogram;Legal patent;Licensing;Link;link protein;manufacturability;manufacture;Medical;Medicine;Modeling;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroprotection;novel;novel strategies;Oral;Oxygen;Patients;Penetration;Peptides;Persons;Pharmaceutical Preparations;Phase;phase 2 designs;Phase II Clinical Trials;phase II trial;pre-clinical;pre-Investigational New Drug meeting;preclinical efficacy;prevent;Production;programs;Protocols documentation;Publishing;receptor;Receptor Activation;Reporting;Request for Applications;Risk;Safety;safety study;Schedule;small molecule;Solubility;Specialist;Structure;subcutaneous;Therapeutic;Time;Toxic effect;Toxicokinetics;Toxicology;Treatment Protocols;trial planning;Universities;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;Vision;Work

PROJECT_TITLE: PNA5: A Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Vascular Dementia and  Alzheimer's Disease Related Dementia: an FDA required Toxicology Study


PROJECT_TERMS: Animals;Attenuated;Back;Baltimore;Biological Markers;Biology;Cancer Biology;cancer cell;Cancer Patient;Cells;Clinical;Clinical Management;commune;Competence;Deposition;Development;Disease;Disease Progression;Distant;Distant Metastasis;Dose;effective intervention;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Failure;first-in-human;Future;genomic data;Histology;human data;Image;imaging biomarker;Immune;Immunologic Markers;improved;Liquid substance;Malignant neoplasm of prostate;men;Mesenchymal;metastatic process;Micrometastasis;Microscopic;mouse model;multidisciplinary;Mus;Natural History;Neoplasm Circulating Cells;Neoplasm Metastasis;non-invasive imaging;Pathway interactions;Pattern;phase II trial;Phenotype;pre-clinical;Primary Neoplasm;Process;programs;Property;prospective;Prostate;prostate cancer cell;prostate cancer metastasis;prostate cancer model;Radiation;Radiation Oncology;Radiation therapy;radiomics;Randomized;randomized trial;Recurrence;Research Design;Site;Techniques;Testing;Therapeutic;Tissues;treatment effect;tumor;tumor microenvironment

PROJECT_TITLE: Radiation modulation of cell plasticity programs determine prostate cancer oligometastatic potential


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Memory impairment and disruptions in sleep architecture co-occur in various neurological disorders, suggesting that elucidating the mechanisms underlying the entanglement between memory and sleep may offer the opportunity to improve the lives of people suffering from memory disorders as well as promote the significance of healthy sleep habits for the general public. The proposed multidisciplinary project seeks a transformative understanding of memory processes and consolidation during sleep by combining the unique capability of direct recordings from the human brain at multiple levels of resolution—single neurons, localized neuronal assemblies, intracranial local field potentials—in neurosurgical patients monitored with intracranial depth electrodes, and computational power of artificial intelligence. Furthermore, the project will probe causal mechanisms of consolidation by application of auditory and electrical stimulations—with high temporal and spatial precision— using innovative model-driven closed-loop technology, which can help lay the foundation for future therapeutic interventions of memory disorders.

PI_NAMEs: FRIED, ITZHAK  (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Acoustic Stimulation;aging population;Alzheimer's Disease;Animals;Area;Artificial Intelligence;Auditory;Auditory area;awake;Behavior;Brain;Brain region;Cells;Clinical;Code;Cognitive;Coupling;Data;deep learning;deep learning algorithm;deep learning model;Development;Electric Stimulation;Electrodes;Electrophysiology (science);Episodic memory;Event;experience;Face;Foundations;Future;General Population;Goals;Hippocampus;Human;improved;innovation;interdisciplinary approach;interdisciplinary collaboration;Intervention;Knowledge;Life;Maps;Measures;medial temporal lobe;Memory;memory consolidation;Memory Disorders;Memory impairment;memory process;memory recognition;memory retrieval;Methodology;Modeling;movie;multidimensional data;multidisciplinary;multimodality;Nature;Nervous System Disorder;neural;neural patterning;Neurodegenerative Disorders;neuromechanism;Neurons;Neurosciences;neurosurgery;novel;novel therapeutics;Participant;Patient Monitoring;Pattern;Performance;Personal Satisfaction;Persons;Physiologic pulse;Physiological;Physiology;Play;predictive modeling;Prevalence;Probability;Process;Protocols documentation;recruit;Research;Resolution;Response to stimulus physiology;Retrieval;Rodent;Sample Size;Sampling;Scheme;Series;Site;Sleep;Sleep Architecture;sleep behavior;Slow-Wave Sleep;Stimulus;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Tsunami;Wakefulness;white matter

PROJECT_TITLE: Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Nutrition;Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Social Determinants of Health;Urologic Diseases

PI_NAMEs: SIMONE, NICOLE L (contact)

PROJECT_TERMS: Affect;Biology;c-myc Genes;Caloric Restriction;cancer cell;Cancer Control;Cancer Etiology;Cancer Patient;cancer survival;cancer therapy;chemotherapy;Clinical;Clinical Trials;Coupled;Data;Diagnostic;Diet Modification;Disease;disorder control;DNA Sequence Alteration;Down-Regulation;Drug usage;effector T cell;Environment;Eragrostis;Evaluation;first-in-human;Future;Genomics;glucogenesis;Growth;Hormones;imaging modality;immune function;improved;improved outcome;Intervention;Laboratories;Lead;lipid biosynthesis;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Metabolic;Metabolic Pathway;metabolic profile;Metabolic syndrome;Metabolism;metabolomics;Molecular;molecular drug target;Molecular Profiling;Mus;Neoplasm Metastasis;neoplastic cell;Nutritional;Nutritional Requirements;Obesity;Oncogenes;Outcome;Pathway Analysis;Pathway interactions;patient population;patient subsets;Patient-Focused Outcomes;Patients;personalized approach;Positron-Emission Tomography;Pre-Clinical Model;precision medicine;precision nutrition;prevent;programs;prostate cancer cell;prostate cancer model;Prostatectomy;Prostatic Neoplasms;Race;Radiation;Radiation Oncology;radiation response;Radiation therapy;Regulatory T-Lymphocyte;response;Role;Serum;social health determinants;social influence;stressor;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Therapeutic Uses;Time;treatment optimization;treatment response;trial design;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;tumor progression;Vision

PROJECT_TITLE: Metabolic implications of radiation response in oligometastatic prostate cancer.


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Delaware Center for Neuroscience Research Public Health Relevance Summary The foundation of Phase III proposal is Delaware’s expanding set of human and research resources in neuroscience, which has Delaware neuroscience research competitive on a national level. Our project supports research aimed at determining how thoughts, memories, feelings and actions emerge from dynamic activities in the brain and are changed over time; as well educational programs to develop a workforce that can participate in and benefit from advances in our understanding of brain function. An increased understanding of how the brain and nervous system functions will facilitate treatments for diseases and injuries and provide insights into human behavior, biases, and cognition.

PI_NAMEs: HARRINGTON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Animals;Applications Grants;Award;base;Basic Science;Behavior;biomedical imaging;Biomedical Research;Brain;Brain imaging;Caliber;career;Cells;Centers of Research Excellence;Cognition;Collaborations;Communities;Core Facility;Data;Delaware;Development;Disease;Education;Electrodes;Electrophysiology (science);Ensure;Environment;equity, diversity, and inclusion;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Faculty;Faculty Recruitment;Feeling;Fostering;Foundations;Funding;Genetic;Goals;Grant;Historically Black Colleges and Universities;Human;Human Resources;human subject;improved;Infrastructure;Injury;innovation;insight;Institution;inter-institutional;Invertebrates;Investments;life span;Magnetic Resonance Imaging;meetings;member;Memory;Mentored Research Scientist Development Award;Mentors;Minority;Modeling;Molecular;Nervous System;Nervous System Physiology;neuroimaging;Neurosciences;Neurosciences Research;non-invasive imaging;operation;patch clamp;Phase;Physiology;Pilot Projects;Productivity;Program Development;programs;public health relevance;Publications;Research;Research Activity;research data dissemination;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Rodent Model;Services;skills;Slice;Structure;Structure-Activity Relationship;Study Section;success;symposium;Thinking;Time;Tissues;Training;Training Activity;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: COBRE Phase III: Delaware Center for Neuroscience Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Administrative Supplement;Advisory Committees;Annual Reports;Award;Behavior;Biomedical Research;Brain;Centers of Research Excellence;Cognition;Communities;Core Facility;Delaware;Development;Development Plans;Disease;Education;Eligibility Determination;Ensure;Environment;equity, diversity, and inclusion;Evaluation;faculty support;Feeling;Fostering;Foundations;Funding;Funding Opportunities;Goals;Growth;Guidelines;Heart;Human;Human Resources;Individual;Injury;innovation;insight;Institution;Investments;Leadership;meetings;Memory;multidisciplinary;National Institute of General Medical Sciences;Nervous System;Nervous System Physiology;Neurosciences;Neurosciences Research;operation;Outcome;Output;Performance;Phase;Process;Productivity;programs;public health relevance;Reporting;Research;Research Personnel;Research Support;Resources;Role;Scientist;Strategic Planning;Structure;student training;Study Section;success;symposium;Teacher Professional Development;Thinking;Time;Universities;Veterans


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: REN, LEI  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;base;Basic Science;Biology;Clinical;Clinical Sciences;cloud based;Collaborations;Computer software;cone-beam computed tomography;cost effective;Data;Data Analyses;Data Collection;Data Engineering;data ingestion;data integration;data quality;data sharing;Data Storage and Retrieval;data warehouse;Database Management Systems;Databases;deep learning;design;Development;Dose;dosimetry;electronic data;Ensure;experience;Faculty;Fees;Future;genome-wide analysis;graphical user interface;high dimensionality;Image;Imaging Techniques;improved;Information Systems;Infrastructure;innovation;Institution;interest;Internet;Laboratories;Magnetic Resonance Imaging;Maryland;Medicine;meetings;member;Methods;Mind;multidimensional data;Multimodal Imaging;Multiomic Data;multiple omics;Organ;outcome prediction;Pathology;Patients;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;Procedures;Process;programs;Radiation Oncology;Radiation therapy;radiomics;Recording of previous events;Research;Research Personnel;Resource Sharing;Retrieval;Risk;Role;Service delivery model;Services;System;Techniques;tool;Training;treatment planning;treatment response;tumor;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Resource Sharing Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PI_NAMEs: SCHNEIDER, KEITH ALLAN (contact)

PROJECT_TERMS: Animal Model;Animals;Applications Grants;Area;Award;base;Behavior;Behavioral;Bioinformatics;Biological;Biomedical Engineering;biomedical imaging;Brain;Brain imaging;career;Centers of Research Excellence;Cognition;Collaborations;Communities;Consultations;Data;data acquisition;Data Analyses;Delaware;Disease;Education;Environment;Evaluation;experience;Experimental Designs;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Faculty;Feeling;Foundations;Funding;Genetic;Goals;Grain;Grant;Human;human data;human imaging;human model;Human Resources;human subject;Imaging technology;improved;Injury;innovation;insight;Investigation;Investments;life span;Magnetic Resonance Imaging;Maps;medical schools;Memory;Methods;Molecular;multidisciplinary;Nervous System Physiology;neuroimaging;Neurosciences;Neurosciences Research;non-invasive imaging;Pathologic;Phase;Positioning Attribute;Productivity;programs;Psychologist;public health relevance;Publications;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Rodent Model;Signal Transduction;Structure;Techniques;Technology;Thinking;Time;United States National Institutes of Health;Universities

PROJECT_TITLE: Center for Biomedical and Brain Imaging (CBBI)


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: MARCHIONNI, LUIGI  (contact)

PROJECT_TERMS: algorithmic methodologies;analytical method;Basic Science;Big Data;Bioinformatics;Biology;Biometry;Clinical Sciences;cloud based;Collaborations;Communities;Complex;Computational Biology;Computer software;Computing Methodologies;coping;Data;data integration;Data Science;data sharing;Data Storage and Retrieval;Development;Dryness;Education;educational atmosphere;Elements;empowerment;Ensure;Evolution;experience;Faculty;file format;Fostering;Generations;genome sciences;genomic data;Genomics;hands-on learning;Image;Image Analysis;in situ imaging;innovation;Institution;interest;Investigation;Laboratories;Laboratory Scientists;Learning;Light;Liquid substance;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medicine;meetings;member;metabolomics;Methodology;Methods;Mission;Modernization;Molecular Analysis;multimodal data;multimodality;novel;Pathology;Persons;Population;Positioning Attribute;Process;Production;programs;Radiation Oncology;radiomics;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Scientist;Standardization;Systems Biology;Technology;tool;Training;Training Activity;transcriptomics;Work

PROJECT_TITLE: Cross Training Core


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Numerous attempts of drug therapy to substantially impact the outcome of patients suffering from glioblastoma have failed over the last 15 years. Indeed, the approval of temozolomide chemotherapy dates back to 2005, and bevacizumab will improve quality of life of some patients, however failed to prolong survival. Reasons for failures are tumor heterogeneity, the exquisitely immunosuppressive microenvironment of glioblastoma, the blood-brain barrier preventing sufficient drug concentrations in the brain, investigations of single agents to an unselected patient population rather than combinatorial approaches and biomarker-based treatments of enriched populations. Our U19 proposal unites renowned translational and clinical investigators from two top and NIH-funded institutions with a strength and dedicated research in brain tumors, evaluating and comparing different approaches of optimized immunotherapy against glioblastoma. We leverage collaboration and pipeline(s) of innovative biotechnology companies who will support our proposal with drugs, devices, but also with access to their expertise and experts, platforms and laboratory investigations, as needed. Thus, this U-19 grant will enable and facilitate a powerful new consortium that will synergize and is able to efficiently translate preclinical findings to meaningful early clinical trials and treatments for patients suffering from glioblastoma.

PI_NAMEs: BUTOWSKI, NICHOLAS A (contact);STUPP, ROGER

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Acceleration;Address;Adult;anti-PD-1;anti-PD1 therapy;Antibodies;Antigens;Back;base;bevacizumab;Biological Assay;Biological Markers;Biotechnology;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Brain Neoplasms;brain tissue;Cell Therapy;Cells;Characteristics;checkpoint therapy;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical development;clinical investigation;Clinical Investigator;clinical translation;Clinical Treatment;Clinical Trials;cohort;Collaborations;Combination immunotherapy;combinatorial;Comprehensive Cancer Center;Cytotoxic Chemotherapy;Dedications;design;Development;Devices;Dose;Doxorubicin;Drug Kinetics;early phase clinical trial;electric field;epidermal growth factor receptor VIII;exhaustion;experience;Failure;Family;first-in-human;Fostering;Funding;Genetic;Glioblastoma;Goals;Grant;Hematologic Neoplasms;Heterogeneity;Homing;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;immunogenic;Immunologic Monitoring;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;in vivo;in vivo evaluation;Industry;innovation;Institution;International;Investigation;Knowledge;Laboratories;Lead;Malignant Neoplasms;manufacture;MAP Kinase Gene;Mediating;Modeling;Mus;Neoadjuvant Therapy;neoplasm immunotherapy;neoplastic cell;neuro-oncology;notch protein;novel;Operative Surgical Procedures;Organ;patient population;Patient-Focused Outcomes;Patients;Peripheral;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Population;pre-clinical;Pre-Clinical Model;predictive marker;prevent;Primary Brain Neoplasms;Prior Therapy;Prognostic Marker;programs;prospective;Quality of life;Radiation;Recurrence;Research;Research Personnel;Research Project Grants;Resected;Resources;response;Role;Safety;Scientist;Site;Solid Neoplasm;Sonication;Structure;synergism;System;T-Lymphocyte;targeted treatment;Technology;temozolomide;Testing;Therapeutic;Tissues;Toxic effect;Translating;Translational Research;translational scientist;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Tissue;tumor-immune system interactions;ultrasound;United States National Institutes of Health;Universities

PROJECT_TITLE: Advancing treatment and understanding of immunotherapy in glioblastoma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Health Services;Immunotherapy;Neurosciences;Rare Diseases

PI_NAMEs: BUTOWSKI, NICHOLAS A (contact)

PROJECT_TERMS: Accounting;Award;Brain Neoplasms;California;Cancer Center;Clinical;Clinical Research;Clinical Services;Clinical Trials;Collaborations;Communication;Complex;Data;data sharing;Decision Making;design;Ensure;experience;Fertilization;follow-up;Funding;Glioblastoma;Goals;Grant;Immunotherapy;Individual;industry partner;Institution;Manuscripts;meetings;member;Monitor;neuro-oncology;Neurology;Neurosurgical Procedures;operation;Operations Research;Organization and Administration;Participant;Pilot Projects;preclinical study;Preparation;Principal Investigator;Productivity;programs;Progress Reports;Qualifying;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Support;Resources;San Francisco;Schedule;Supervision;Testing;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Administrative and Clinical Services Core


PI_NAMEs: SUN, JIANLI  (contact)

PROJECT_TERMS: Acceleration;Area;Award;base;Behavior;Biological Models;Biomedical Engineering;Biomedical Research;Brain;Cells;Cellular biology;Centers of Research Excellence;Cognition;Communities;Consultations;Core Facility;Data;data acquisition;Data Analyses;Data Collection;Delaware;Disease;Education;Electrophysiology (science);Ensure;Equipment;equity, diversity, and inclusion;experience;Experimental Designs;experimental study;Faculty;Feeling;Foundations;Funding;graduate student;Growth;Historically Black Colleges and Universities;Human;Human Resources;Infrastructure;Injury;innovation;insight;Institution;instrumentation;Ion Channel;Laboratories;Leadership;Measurable;medical schools;Memory;Methods;Minority Groups;Molecular;multi-electrode arrays;Needs Assessment;Nervous System Physiology;Neurosciences;Neurosciences Research;optogenetics;patch clamp;Phase;Positioning Attribute;programs;public health relevance;Publications;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Scientist;Services;skills;stem cells;Surveys;symposium;Technical Expertise;Techniques;Testing;Thinking;Time;Tissues;training opportunity;Transgenic Model;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cell Electrophysiology Core


PROJECT_TERMS: Agriculture;animal care;Animal Experimentation;animal facility;Animal Model;Animal Technicians;Animal Welfare;Animals;Award;base;Beds;Behavior;Biology;Brain;Cattle;Cells;Centers of Research Excellence;Characteristics;Charge;Cognition;cost;Data;data streams;Dedications;Delaware;Detection;digital;Disease;Domestic Fowls;drinking;Education;Electrophysiology (science);Ensure;Environment;Environmental Monitoring;Euthanasia;Faculty;Faculty Recruitment;faculty research;faculty support;feeding;Feeling;Floods;Food;food surveillance;Foundations;Funding;Future;Future Teacher;Goat;Grant;Health;Home;Housing;Human;Human Resources;improved;Infrastructure;Injury;insight;Laboratory Animals;laboratory facility;Lateral;Livestock;member;Memory;Monitor;Motor Activity;mouse model;Movement;Natural Resources;Nervous System Physiology;Neurosciences;Neurosciences Research;operation;Phase;Positioning Attribute;Productivity;programs;Psychology;public health relevance;Quality of Care;Quarantine;real time monitoring;recruit;Research;Research Personnel;Research Project Grants;Research Subjects;Research Support;Resources;Rodent;Running;Science;sensor;Sheep;Supporting Cell;System;Thinking;Time;tissue slice preparation;translational potential;Universities;ventilation;Veterinarians;Water

PROJECT_TITLE: Vivarium Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Ceramides are products of fat and protein metabolism that accumulate in individuals with obesity or dyslipidemia and are strongly linked to insulin resistance. Herein we propose to leverage large-scale epidemiologic and clinical cohorts to identify associations of ceramides with colorectal cancer risk, and animal experiments to study the efficacy of new ceramide-lowering interventions. Our study will clarify the key role of ceramides in the metabolic dysregulation underlying colorectal cancer and identify new targets for colorectal cancer prevention.

PI_NAMEs: PLAYDON, MARY CHRISTINE (contact);SUMMERS, SCOTT A;ULRICH, CORNELIA M

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Acceleration;Address;adenoma;Adipose tissue;Affect;age difference;age group;Anabolism;Animal Experiments;Automobile Driving;Azoxymethane;bariatric surgery;base;Binding;Biological;Blood Banks;Body Composition;Body Weight;Body Weight Changes;Cancer and Nutrition;cancer biomarkers;cancer prevention;cancer risk;Cells;Ceramides;Clinical;cohort;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Complex;Data;Deposition;desaturase;design;Development;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Dietary Practices;dietary restriction;dihydroceramide desaturase;drug candidate;Dyslipidemias;efficacy study;Enzymes;Epidemiology;Ethnic Origin;European;Evaluation;Experimental Models;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;fly;Genes;Genetic;genetic variant;Goals;Health;Heart Diseases;Heart failure;Human;Hyperinsulinism;Incidence;Individual;Inflammation;inhibitor;Insulin Resistance;interdisciplinary collaboration;Intervention;Intestines;Investigation;Knock-out;Lesion;Link;lipid metabolism;Lipids;Liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediator;Medical;Metabolic;Metabolic dysfunction;Metabolism;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nutrition;Nutritional;Obesity;obesity biomarkers;Organ;Organoids;Overweight;Palmitoyl Coenzyme A;pandemic disease;Participant;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Physical condensation;pi bond;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Proliferating;prospective;protein metabolism;Public Health;Publishing;Race;Resources;response;Risk;Rodent;Role;Serine;Serum;sex;Signal Transduction;Site;stem cell proliferation;stem cells;Testing;therapeutic candidate;Time;Time-restricted feeding;Tissues;translational approach;tumor;tumor metabolism;Utah;Variant;waist circumference;Waist-Hip Ratio

PROJECT_TITLE: Ceramides as novel drivers of metabolic dysfunction and colorectal cancer


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Rare Diseases

PI_NAMEs: PHILLIPS, JOANNA  (contact)

PROJECT_TERMS: blood-brain barrier crossing;Brain Neoplasms;California;Cells;Clinic;Clinical Trials;Confidentiality of Patient Information;Dedications;Development;Dissociation;Ensure;experimental analysis;Flow Cytometry;Glioblastoma;Glioma;Goals;high dimensionality;Human;Immunologic Monitoring;Immunotherapy;Informed Consent;Knowledge;Leadership;Molecular Analysis;Mus;neuropathology;novel;Operating Rooms;participant enrollment;Patients;Performance;Pre-Clinical Model;preservation;Procedures;Process;Quality Control;Regulation;Research Personnel;San Francisco;Science;single-cell RNA sequencing;Techniques;Testing;Tissues;tumor;Tumor Tissue;Universities;Xenograft procedure

PROJECT_TITLE: Immune Monitoring and Biospecimen Core


PROJECT_TERMS: Applications Grants;Award;Behavior;biobehavior;Brain;career networking;Centers of Research Excellence;clinical application;Cognition;Collaborations;Core Facility;Creativeness;Data;Delaware;Development;Discipline;Disease;Education;Educational workshop;experience;Faculty;faculty support;Feeling;Fostering;Foundations;Funding;Generations;Goals;Grant;Growth;Human;Human Resources;human subject;Incubated;Infrastructure;infrastructure development;Injury;insight;Institution;inter-institutional;Interdisciplinary Study;Invertebrates;Joints;Knowledge;Lead;Memory;Mentors;Mission;Modeling;Nervous System Physiology;neuroethics;neuroimmunology;Neurosciences;Neurosciences Research;Peer Review;Phase;Pilot Projects;Preparation;Productivity;Program Research Project Grants;programs;public health relevance;Publications;Publishing;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Rodent;Running;Scientist;social neuroscience;Structure;success;support network;symposium;Thinking;Time;tool;Training;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: SONABEND, ADAM M (contact)

PROJECT_TERMS: Address;Adjuvant;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Antibodies;Antigen Presentation;Antitumor Response;Autologous;Biological Markers;Biopsy;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Brain Neoplasms;brain tissue;Breast Cancer Patient;Bypass;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Characteristics;Clinical;Clinical Trials;cohort;Cohort Studies;Combined Modality Therapy;Contralateral;cranium;cytotoxic;density;Devices;Dose;Doxorubicin;drug distribution;Drug Kinetics;Drug or chemical Tissue Distribution;Excision;Exhibits;Exposure to;Failure;genetic signature;Glioblastoma;Glioma;Goals;Heterogeneity;Human;immune checkpoint blockade;Immune response;immunogenic;immunogenicity;Immunohistochemistry;Immunologic Surveillance;immunoregulation;Immunotherapy;Impairment;Implant;implantable device;improved;improved outcome;in vivo evaluation;Infiltration;innovation;Interferon Type II;Intravenous;Lead;Long-Term Survivors;Maintenance;MAP Kinase Gene;Measures;Microbubbles;Molecular;Mus;Myeloid Cells;Neoadjuvant Therapy;neoplastic cell;novel;novel therapeutics;objective response rate;Operative Surgical Procedures;Outcome;Patient Recruitments;patient subsets;Patients;Penetration;Peripheral;personalized medicine;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;predicting response;primary endpoint;Property;Prospective cohort;Recurrence;Regimen;Reporting;Research;response;Role;Safety;secondary endpoint;Signal Transduction;Site;skull implant;Sonication;Specimen;Stains;standard of care;Survival Analysis;survival prediction;System;T-Cell Activation;T-Lymphocyte;Testing;Time;Tissues;TNF gene;trial comparing;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor Tissue;tumor-immune system interactions;ultrasound;Work

PROJECT_TITLE: Leveraging doxorubicin immune-modulation, blood-brain barrier opening, and personalized medicine for effective immunotherapy in glioblastoma. A mechanistic approach and pharmacokinetic trial.


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: OKADA, HIDEHO  (contact)

PROJECT_TERMS: Adolescent;Adopted;Adult;Antigens;B lymphoid malignancy;Biodistribution;Blood;blood-brain tumor barrier;Body System;Brain;Brain Neoplasms;cancer immunotherapy;CAR T cell therapy;Cell Therapy;Cells;Central Nervous System;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;cohort;Collaborations;cytotoxicity;Data;design;Development;Dose;Engraftment;Enrollment;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;exhaustion;experience;first-in-human;Funding;Glioblastoma;Goals;Good Manufacturing Process;Grant;Heterogeneity;Homing;Human;Immunologic Monitoring;Immunotherapy;In Vitro;in vivo;Infiltration;Inflammation;innovation;Intravenous;Intravenous infusion procedures;invention;Investigational Drugs;Investigational New Drug Application;Lentivirus;Lentivirus Vector;Malignant Neoplasms;manufacture;manufacturing process;Maximum Tolerated Dose;Medical;Memory;Methods;mutant;neoplastic cell;Nervous System;New Drug Approvals;notch protein;novel;Operative Surgical Procedures;Organ;patient derived xenograft model;Patients;Pharmacodynamics;Phase;phase 1 study;Phase I Clinical Trials;phase I trial;Phenotype;Pre-Clinical Model;preclinical efficacy;Procedures;Process;prospective;quality assurance;receptor;Recurrence;Research Personnel;Resected;Safety;Signal Transduction;Solid;stem;Surface Antigens;System;T cell therapy;T-Lymphocyte;Testing;Tissues;Toxic effect;Toxicology;Translation Process;tumor;Tumor Tissue;ultrasound;United States National Institutes of Health

PROJECT_TITLE: Development of novel synNotch CART cell therapy in adult patients with recurrent EGFRvIII+ glioblastoma


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Public Health Relevance Project Narrative: The goal of this career development award is to transition Dr. Brady Post to independence as a health services researcher with a long-term research agenda focused on how system-level integration of providers affects quality and equity. Rapid and widespread integration between hospitals and cardiologists has unknown consequences for health equity, particularly among rural residents. This grant will apply mixed methods to collect insights from physicians, managers, and patients, providing the evidence needed to develop an effective policy response to the opportunities and dangers presented by widespread hospital-physician integration.

PI_NAMEs: POST, BRADY  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Implications of hospital-physician integration for urban-rural equity in access, care coordination, and outcomes.

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECTIVE NARRATIVE The heterogeneity of chronic pain conditions, and the complexity and diversity of underlying pathological mechanisms, make it challenging to identify tractable targets with broad implications for therapy. This proposal will identify a convergent signaling protein linking nociceptive activity to the maladaptive synaptic plasticity that underlies the development of chronic pain triggered by different pathological factors. This contribution is significant because it uncovers a conserved mechanism underlying the development of different types of chronic pain and identifies a novel therapeutic target that could be translated into the clinic to treat chronic pain with broad implications.

PI_NAMEs: LI, LINGYONG  (contact);TOLIAS, KIMBERLY R

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Actins;Antisense Oligonucleotides;Brain;central sensitization;chemotherapy;chronic pain;chronic pain management;chronic painful condition;Clinic;Cre driver;Cytoskeletal Modeling;Dendritic Spines;density;Development;Diabetes Mellitus;dorsal horn;effective therapy;excitatory neuron;functional plasticity;genetic manipulation;Growth;Heterogeneity;Hypersensitivity;Inflammation;inflammatory pain;Link;link protein;LoxP-flanked allele;Mediating;Modeling;Molecular;Morphogenesis;Mus;Nature;nerve injury;neural;Neurotrophic Tyrosine Kinase Receptor Type 2;new therapeutic target;Nociception;pain processing;painful neuropathy;Pathologic;Peripheral;Peripheral nerve injury;Play;polymerization;Polymers;Population;Posterior Horn Cells;prevent;Rattus;Research;rho GTP-Binding Proteins;Rodent Model;Role;Signal Pathway;Signal Transduction;Signaling Protein;spared nerve;Spinal;Spinal nerve structure;Synapses;Synaptic plasticity;Synaptic Potentials;targeted treatment;Testing;Therapeutic Effect;therapeutic target;Transgenic Organisms;Translating;Vertebral column;Viral Vector

PROJECT_TITLE: The conserved mechanisms underlying different types of chronic pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative The application is aimed to support NCI-funded cancer research projects from investigators at the Wistar Institute Cancer Center, the Fox Chase Cancer Center at Temple University, the Sidney Kimmel Cancer Center at Thomas Jefferson University, and other academic institutions using proteomics and metabolomics technologies offered by the Wistar Proteomics and Metabolomics Shared Resource. Supported research projects are diverse with focus on many different types of cancer, such as prostate, ovarian, and melanoma, and experimental samples include immortalized or primary cells, biological fluids, and tissues. The analytical assays will provide insight into perturbed biological pathways and identify key biomolecules associated with disease states, with the final goal of developing methods for cancer prevention, diagnosis and treatment.

PI_NAMEs: TANG, HSIN-YAO  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Biological;Biological Assay;Cancer Center;cancer prevention;Cancer Research Project;cancer type;Cells;Chemicals;Computer software;Consultations;cost;crosslink;Data;Data Analyses;Development;Diagnosis;Disease;Ensure;exosome;Experimental Designs;Fatty Acids;Fox Chase Cancer Center;Funding;Future;Goals;improved;insight;Institution;instrumentation;Ions;Isotopes;Kimmel Cancer Center at the Thomas Jefferson University;Label;Lipids;Liquid substance;Malignant Neoplasms;Melanoma;metabolomics;Methodology;Methods;Modification;Ovarian;palmitoylation;Pathway interactions;Peptides;Performance;Post-Translational Protein Processing;Prostate;protein complex;Proteins;Proteomics;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Sampling;Site;stable isotope;success;Technology;The Wistar Institute;Tissues;Tracer;Universities;Update

PROJECT_TITLE: Advancing Cancer Research through Comprehensive Proteomics and Metabolomics Analyses


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Lupus;Racial and Ethnic Minority Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Lupus is a chronic, multisystem, autoimmune disease with profound associated morbidity and early mortality that disproportionally affects women and certain ethnic populations (e.g., Asian). Lupus has a substantial genetic component, and recent studies on lupus and other autoimmune diseases have linked several single nucleotide polymorphisms (SNPs) with autophagy-related genes, suggesting their role in lupus and general autoimmunity. This project will identify and map the most likely SLE-predisposing variants at six autophagy-related loci discovered in Asian populations, determine their functional roles, and uncover the molecular mechanisms that contribute to SLE pathogenesis across multiple ethnicities.

PI_NAMEs: NATH, SWAPAN K. (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;African American;African American population;Age;Algorithms;Alleles;Animal Model;Antigen-Antibody Complex;Asian;Asian Americans;Asian population;Autoantibodies;Autoimmune Diseases;Autoimmunity;Autophagocytosis;autoreactivity;B-Lymphocytes;base editing;Biochemical;Biological;Biological Assay;Biology;Catabolic Process;causal variant;CDKN1B gene;Cell Line;Cell Physiology;Cells;Cellular biology;Chromatin;Chronic;chronic autoimmune disease;Clinical;clinical heterogeneity;Clustered Regularly Interspaced Short Palindromic Repeats;Crohn's disease;curative treatments;Cytoplasm;Data;Deposition;Diagnosis;Disease;disease phenotype;Disproportionately impacts women;DNA Resequencing;Drug Targeting;effective therapy;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;European;European ancestry;follow-up;Follow-Up Studies;Gender;Genes;Genetic;Genetic Heterogeneity;Genetic study;Genetic Transcription;genome wide association study;Genotype;Gifts;Heritability;High Prevalence;Hispanic Americans;Hispanic Populations;Homeostasis;Human;IGA Glomerulonephritis;Immune;Immune System Diseases;Individual;Inflammation;Inflammatory;Intervention;Kidney;kidney cell;knockout gene;Knowledge;Lead;Life;Link;Linkage Disequilibrium;Lupus;Lupus Nephritis;Lymphocyte;Lysosomes;Maps;Mediating;Metabolic stress;Minority Groups;misfolded protein;Molecular;Molecular Mechanisms of Action;Morbidity - disease rate;mortality;multi-ethnic;multiorgan damage;Multiple Sclerosis;Nephritis;novel;Nucleic Acid Regulatory Sequences;Organ;Organelles;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patients;Play;podocyte;Population Heterogeneity;Predisposition;Process;Production;protein degradation;rare variant;Regulation;Regulatory Element;Reporting;Research;Resources;response;Risk;risk variant;Role;Sampling;sex;Signal Transduction;Single Nucleotide Polymorphism;Skin;Structure;Susceptibility Gene;synergism;System;Systemic Lupus Erythematosus;T-Lymphocyte;Targeted Resequencing;Tissues;Translating;Variant;Woman

PROJECT_TITLE: Contributions of autophagy-related genes in lupus

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Chlamydia trachomatis (CT) infection remains the most prevalent sexually transmitted infection worldwide and causes a significant disease burden, especially reproductive morbidity in women. Understanding T cell-mediated immune responses that help in clearing CT infection will provide important information for CT vaccine design. This study will examine the role of HLA-E mediated CD8 T cell immune responses in clearing CT infection in women.

PI_NAMEs: BANSAL, ANJU  (contact);GEISLER, WILLIAM M

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: access disparities;Address;African American population;African Women;Alleles;Annual Reports;Antibiotic Therapy;Antigens;Autologous;Bacterial Infections;Biological;burden of illness;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell mediated immune response;Cells;Cellular Immunity;Chlamydia;Chlamydia trachomatis;Clinical;cohort;Communicable Diseases;Cytolysis;Data;Dendritic Cells;direct application;Disease;Disproportionately impacts women;Ectopic Pregnancy;Enrollment;Enzyme-Linked Immunosorbent Assay;experience;Female;Flow Cytometry;Future;Genus Mycobacterium;global health;granule cell;Healthcare;Histocompatibility Antigens Class I;HIV;HLA Antigens;HLA-A gene;Human;Immune;Immune response;Immunity;immunogenic;In Vitro;Individual;Infection;infection rate;Infertility;insight;Interferon Type II;major outer membrane protein;Mediating;Memory;Methodology;Modality;Molecular;monocyte;mouse model;Mycobacterium tuberculosis;Nature;Nucleic Acid Amplification Tests;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptides;perinatal complications;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Physiologic pulse;Play;Prevention;Production;Reagent;Recording of previous events;Reporting;reproductive;reproductive morbidity;Resources;response;Risk;Role;Salmonella;screening;Seminal;Sexually Transmitted Diseases;T cell response;T-Lymphocyte;Testing;Time;TNF gene;tool;transmission process;Typhoid Fever;Vaccination;Vaccine Design;Vaccines;Virus Diseases;Vulnerable Populations;Woman;Women's Group;women's morbidity;Work

PROJECT_TITLE: The role of Chlamydia trachomatis specific HLA-E restricted CD8 T cell responses in clearance of infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Hepatitis C virus (HCV) infection is a significant public health challenge especially among people who inject drugs (PWID) and people living with HIV (PLWH), populations disproportionately represented within the Department of Corrections. To improve the HCV care continuum, the Louisiana Department of Health launched a comprehensive HCV Elimination Plan that includes an alternative payment strategy to provide access to HCV medications and a peer-support treatment program, Connect for Cure, within correctional facilities. In this project, we will investigate the impact of HCV treatment in HIV/HCV coinfected and HCV monoinfected incarcerated persons on HCV elimination.

PI_NAMEs: IRVIN, RISHA  (contact);THOMAS, DAVID L

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Age;barrier to testing;Chronic Hepatitis C;chronic infection;Clinic;Communities;Continuity of Patient Care;correctional system;cost;curative treatments;Data;Databases;design;Drug usage;economic impact;Ensure;Epidemic;Epidemiology;experience;flexibility;Funding;Future;Goals;Harm Reduction;Health;Hepatitis C;Hepatitis C Acquisition;Hepatitis C Antibodies;Hepatitis C co-infection;Hepatitis C Incidence;Hepatitis C Prevalence;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C Viremia;Hepatitis C virus;HIV;HIV Infections;HIV Seropositivity;HIV/HCV;Imprisonment;improved;Incentives;Incidence;Individual;Infection;infection burden;Injecting drug user;injection drug use;Intervention;Jail;Knowledge;Learning;Liver Failure;Louisiana;Malignant neoplasm of liver;Modeling;models and simulation;Morbidity - disease rate;mortality;payment;peer support;Persons;Pharmaceutical Preparations;Population;Prevalence;Price;Prisons;programs;Public Health;Race;Research;Research Proposals;Risk Behaviors;RNA;Route;Sampling;scale up;sex;success;Testing;Time;tool;transmission process;treatment program;Viral;viral RNA;virus testing

PROJECT_TITLE: The Impact of HCV Treatment in HIV/HCV coinfected and HCV monoinfected Incarcerated Persons on HCV Elimination

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: LAS CRUCES

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative Human biology depends on complex circuits of communication between our cells and tissues, and when this communication becomes dysregulated disease can occur. Technologies have been developed to “listen in” on the communications between our cells by measuring the cellular release of signaling molecules, but these tools are poorly suited for measuring the release of macro-molecular signaling vehicles called exosomes. Our research program develops new technologies needed to “listen in” on exosome-mediated communications, which will ultimately lead to a better understanding the mechanisms of neurological and metabolic disorders.

PI_NAMEs: BAKER, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Biological Assay;Brain;Cells;Circadian Rhythms;Communication;Communities;Complex;Dimensions;Disease;exosome;extracellular;extracellular vesicles;Goals;Human Biology;Immunoassay;In Situ;intercellular communication;Lipids;Measurement;Measures;Mediating;Metabolic Diseases;Microfluidics;Nervous System Disorder;new technology;new therapeutic target;novel;Pathology;Perfusion;programs;Research;Role;Sampling;Signal Transduction;Signaling Molecule;Slice;suprachiasmatic nucleus;System;Technology;tissue culture;Tissues;tool;Vesicle;vesicular release

PROJECT_TITLE: New technologies for in situ measurement of exosome release from brain slice cultures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public health narrative Atherosclerosis of the arteries feeding the brain, even in the absence of artery narrowing, is thought to be responsible for a significant percentage of unexplained strokes. While vessel wall magnetic resonance imaging (MRI) of brain arteries can image atherosclerosis, there are no efficient ways to measure them across multiple hospital scanners to understand how to treat such strokes. We will develop an automated analysis software using artificial intelligence-based methods to help clinicians measure the level of atherosclerosis and thereby allow them to use vessel wall MRI in clinical decision making of unexplained strokes.

PI_NAMEs: MOSSA-BASHA, MAHMUD ;YUAN, CHUN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;adaptive learning;Adopted;Adoption;Affect;American;analysis pipeline;Angiography;Arterial Fatty Streak;arterial tortuosity;Arteries;Artificial Intelligence;artificial intelligence algorithm;Atherosclerosis;automated analysis;Blood Vessels;Brain;Brain imaging;Brain Infarction;brain magnetic resonance imaging;burden of illness;cerebrovascular;Characteristics;Clinical;clinical application;clinical decision-making;clinical diagnosis;clinical practice;Computer software;Computers;Consumption;conventional therapy;Data;Dedications;deep learning;dementia risk;Detection;Development;Diagnosis;Disease;disease diagnosis;Disease Progression;embolic stroke;Embolism;empowerment;experience;feeding;High Prevalence;Hospitals;Image;Image Analysis;image registration;improved;individual patient;intracranial artery;Intracranial Atherosclerotic Disease;Ischemic Stroke;Knowledge;Label;Lacunar Infarctions;Lesion;machine learning model;Magnetic Resonance Imaging;Measurement;Measures;Medical;Methods;Modernization;Monitor;Morphologic artifacts;Multicenter Studies;Neurological outcome;neuropathology;novel;Pathology;Patients;Pattern;Performance;prevent;Process;Protocols documentation;Public Health;radiologist;Reader;Recommendation;Registries;Reproducibility;Research;Resolution;Role;Scanning;Scheme;screening;Signal Transduction;Societies;Source;Stenosis;Stroke;Structure;Symptoms;systematic review;Techniques;Testing;Therapy Clinical Trials;Time;tool;Training;transfer learning;Trees;Vendor

PROJECT_TITLE: Automated Intracranial Vessel Wall Analysis Pipeline for Multi-contrast Multi-platform Applications


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Glioblastoma is the most common malignant brain tumor and one of the deadliest human cancers. We found that calcium channels, known as T-Type calcium channels, are upregulated in glioblastoma and drive malignancy. We propose to study what T-Type calcium channels do in glioblastoma, how they work, how they interact with the surrounding brain, and if we can target them for therapy using a repurposed FDA approved drug and other therapeutic strategies. If successful, these studies will improve our understanding of the molecular mechanisms of glioblastoma and lead to the development of new and more efficient therapies.

PI_NAMEs: ABOUNADER, ROGER  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: angiogenesis;Animal Model;Apoptosis;Brain;Calcium;Calcium Channel;Calcium Channel Blockers;Calcium Signaling;cell growth;Cell Physiology;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical translation;Clinical Trials;Coculture Techniques;Combined Modality Therapy;CRISPR screen;Cytosol;Data;Development;Drug Synergism;druggable target;Event;Extracellular Space;FDA approved;Genetic Transcription;Genomics;Glioblastoma;Growth;Human;Immune;Immunocompetent;improved;In Vitro;in vitro Assay;in vivo;Knowledge;Life Expectancy;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mibefradil;Modality;Molecular;Motility;mouse model;multidisciplinary;Mus;neoplastic cell;neuro-oncology;Neurons;Neurosciences;neurotransmission;new combination therapies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;optimal treatments;Pharmaceutical Preparations;Phase;Prognosis;Proteomics;Publications;Radiation therapy;Recurrence;Regimen;Research;Role;screening;standard of care;stem cells;Synapses;Synaptic plasticity;T-Type Calcium Channels;Testing;Therapeutic;therapeutic target;tool;Transgenic Organisms;Translating;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Calcium Channels in Glioblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research is relevant to public health because it addresses fundamental questions about sleep biology. Despite the importance of sleep for human health, our understanding of how sleep is controlled remains rudimentary. In this proposal, we will use a simple sleep model to investigate the basic mechanisms of sleep regulation at the molecular, cellular, and circuit levels, which will provide new insights into a general principle of sleep regulation.

PI_NAMEs: WANG, HAN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adverse effects;Affect;Animals;Arousal;Behavior;Behavioral;behavioral phenotyping;Biological Process;Biology;Brain;brain control;Caenorhabditis elegans;Cellular Stress;Communities;Disease;Drosophila genus;Epidermal Growth Factor;Genetic;Genetic Screening;Goals;Health;Human;in vivo calcium imaging;Individual;Induced Neurons;insight;Life Cycle Stages;Maps;model organism;Modeling;Modernization;Molecular;mutant;Nervous System;neural;neural circuit;Neurologic;neuromechanism;Neurons;Optics;optogenetics;Organism;Pathway interactions;Performance;Process;Public Health;Reagent;Regulator Genes;Research;Resolution;Resources;Signal Transduction;Sleep;sleep abnormalities;Sleep Disorders;sleep regulation;Societies;Stress;System;Testing;Visualization;Wakefulness;Zebrafish

PROJECT_TITLE: Mechanisms of Sleep Regulation in C. elegans

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Many elderly Veterans and those with spinal cord injury rely on a wheelchair seating system, made up of a wheelchair and an effective pressure relief cushion. Used together these provide mobility and sitting stability while decreasing skin breakdown risk and increasing overall sitting tolerance. This project will develop the next-generation low-cost high-performance customizable modular pressure relief cushion. 3D printing will be used to build cushions with SquishINS inserts that combine lightness and variable stiffness. 30 Veterans who are full-time wheelchair users will use personalized modular cushions for two weeks each. Personalized cushions will be created using a cushion fitting process we have already developed and tested. Microenvironmental conditions will be monitored during use. A cost analysis will ensure the customized modular cushion applies value-driven principles. User satisfaction will be measured along with the effects on daily function, skin status and seated tissue health.

PI_NAMEs: BOGIE, KATH  (contact)

PROJECT_TERMS: 3D Print;Activities of Daily Living;Advanced Development;Algorithms;Area;Benchmarking;Caring;Charge;Clinic;Clinical;Clinical assessments;Clinical Research;commercialization;cost;Cost Analysis;cost effective;daily functioning;Data;decubitus ulcer;design;Development;Disinfection;Elderly;Engineering;Enrollment;Ensure;Evaluation;Foundations;Frequencies;Gel;Generations;Goals;Health;Health care facility;Health Status;Humidity;Individual;innovation;Inpatients;instrument;Life;Long-Term Care;Manual wheelchair;manufacture;Maps;Marketing;Mattresses;Measures;mechanical properties;Mechanics;Medical center;Mobility decline;Monitor;next generation;novel;Nursing Research;Ohio;Participant;Pelvis;Performance;Permeability;Persons;Pilot Projects;Positioning Attribute;Posture;Powered wheelchair;pre-clinical;preclinical development;pressure;prevent;Price;Process;programs;Property;Protocols documentation;prototype;Questionnaires;Randomized;Recommendation;Recovery;repaired;replicator;Research Design;research study;response;Risk;satisfaction;Scheme;Self-Help Devices;sensor;Silicon;Silicones;Skin;Spinal cord injury;Support System;Surface;System;technology platform;Telephone;Temperature;Testing;Time;Tissues;Translations;United States Department of Veterans Affairs;Veterans;Weight;Wheelchair user;Wheelchairs;Willow;Wood material;Work;wound

PROJECT_TITLE: Development of advanced personalized modular pressure relief seating cushion systems: Testing and user evaluation

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE In humans, microRNAs bind to target messenger RNAs and prevent their translation into protein, thereby maintaining the integrity of gene expression. To this end, microRNAs need to be loaded into one of four human Argonaute proteins, but how these proteins recognize their specific target RNAs remains unclear. We will solve this question in our proposed experiments so that the outcome will contribute to the development of a cure for microRNA-mediated diseases.

PI_NAMEs: NAKANISHI, KOTARO  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Untranslated Regions;Acylation;Algorithms;Amino Acids;Anti-viral Response;base;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Process;Cells;Chimera organism;Complex;Cryoelectron Microscopy;design;Designer Drugs;Development;Disease;Dissociation;Drug Design;Equipment and supply inventories;Eukaryotic Cell;Event;experimental study;flexibility;Foundations;Funding;Gene Expression;Gene Silencing;Goals;Guide RNA;HIV;Human;hydroxyl group;Hydroxyl Radical;Immunoprecipitation;improved;Individual;insight;Internal Ribosome Entry Site;Investigation;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;MicroRNAs;Molecular;Molecular Conformation;mutant;N-methylisatoic anhydride;neurodevelopment;novel;novel therapeutic intervention;Nucleotides;Outcome;Outcome Study;prediction algorithm;prevent;Primer Extension;Property;Proteins;Resolution;RNA;RNA Binding;RNA Interference;RNA purification;RNA-Induced Silencing Complex;Role;scaffold;Shapes;Site;Solid;Specificity;Structure;Techniques;Testing;Therapeutic;transcriptome sequencing;Translational Repression;Translations;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Target specificity of human RNA-induced silencing complex

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative This project will develop a novel, cost-effective Intervention, 3D multi-parametric ultrasound imaging (mp-US), for selectively guiding biopsies to detect clinically significant PCa in patients, and demonstrate that 3D mp-US is comparable (i.e., non-inferior) to mp-MRI (the clinical intervention). Thus, at the end of this project our partnership will deliver an accurate, 3D mp-US system ready for clinical deployment. mp-US prostate rev3 narrative DRAFT October 2, 2019 11:56 AM 1

PI_NAMEs: FORSBERG, FLEMMING  (contact);HALPERN, ETHAN J

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: 3-Dimensional;Accounting;American;Area;Behavior;Biological Markers;Biopsy;Cancer Detection;cancer diagnosis;Cessation of life;Clinical;Clinical Trials;clinically significant;Colorectal;contrast enhanced;Contrast Media;Core Biopsy;cost;cost effective;cost effective intervention;cost effective treatment;Dedications;Detection;detection method;Developing Countries;Diagnosis;diagnostic accuracy;Disease;Early Diagnosis;Early treatment;editorial;Elasticity;Engineering;European;Evaluation;Gadolinium;Geography;Gleason Grade for Prostate Cancer;Histopathology;Home;Image;Imaging technology;improved;Industry;industry partner;Intervention;Kidney Failure;Kinetics;Lead;Left;Lesion;Localized Malignant Neoplasm;Lung;Machine Learning;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medial;men;Meta-Analysis;Methods;Microbubbles;Morbidity - disease rate;mortality;Neighborhoods;new technology;novel;novel marker;Ovarian;overtreatment;Participant;Pathologic;Patients;Pilot Projects;portability;Predictive Value;Prostate;Prostate Cancer therapy;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;PSA screening;Radical Prostatectomy;Randomized;Rectum;Resources;ROC Curve;Scanning;Scientist;screening;Screening for Prostate Cancer;screening program;Signal Transduction;socioeconomics;Specificity;standard of care;Structure of base of prostate;System;Techniques;technology/technique;Time;Tissues;Transrectal Ultrasound;treatment program;Ultrasonography;ultrasound;viscoelasticity;Viscosity;Visualization

PROJECT_TITLE: Prostate Cancer Diagnosis by Multiparametric Ultrasound

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative: Recent advances in single cell multi-omic analyses have allowed us to construct a high-resolution map of T cell fate determination in the thymus. We now propose to use that map as a guide to define the molecular links between TCR recognition and T cell fate determination.

PI_NAMEs: ROBEY, ELLEN A (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Adopted;Binding;Calcineurin;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Fate Control;Cells;Data;effector T cell;gene induction;Genetic Transcription;Helper-Inducer T-Lymphocyte;Killer Cells;Lead;Ligands;Link;Literature;Mammalian Cell;Maps;MEKs;migration;Modeling;Molecular;multiple omics;nuclear factors of activated T-cells;Outcome;Pathway interactions;Peptide/MHC Complex;Peptides;Phase;programs;Publishing;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;T-Cell Development;T-Lymphocyte;Testing;thymocyte;Thymus Gland;Time;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Signals that Control Thymocyte Migration


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Mental Health;Neurosciences;Patient Safety;Physical Activity;Prevention;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Long-term survivorship is now a real possibility for patients with relapsed/refractory large B-cell lymphoma (LBCL) treated with the chimeric antigen receptor (CAR) T-cell therapy. Almost nothing is known about neurocognitive and patient-reported outcomes in patients undergoing this treatment, however. The current study will investigate longitudinal changes in these outcomes in the first year after CAR T-cell therapy compared to individuals without cancer.

PI_NAMEs: JIM, HEATHER S.L. (contact);LOCKE, FREDERICK ;SMALL, BRENT JOHN

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Acceleration;actigraphy;Acute;Address;Admission activity;Adult;Adverse event;Age;Attention;B-Cell Lymphomas;Behavior;Behavioral;Biological;Blood;Cancer Survivor;CAR T cell therapy;Cell Aging;Cellular Phone;chimeric antigen receptor;clinical risk;Cognition;Cognitive;cognitive performance;cognitive task;Collaborations;comorbidity;comparison control;contextual factors;cytokine release syndrome;Data;Delirium;Deterioration;Disease;Disease-Free Survival;Ecological momentary assessment;Education;Encephalopathies;Energy Metabolism;Event;Exhibits;Family;Fatigue;FDA approved;Fever;Frequencies;Future;Goals;human old age (65+);Hypotension;Hypoxia;Impaired cognition;improved;In complete remission;Individual;Inflammation;innovation;insight;Internet;Intervention;Length of Stay;leukemia/lymphoma;Life;Long Term Survivorship;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Memory;Mental Depression;modifiable risk;Neurocognition;Neurocognitive;Neurologic;Neuropsychological Tests;Neuropsychology;neurotoxic;neurotoxicity;novel;objective response rate;Outcome;Pain;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;Performance Status;Phase I/II Trial;Physical activity;Population;Prior Chemotherapy;processing speed;protective factors;Quality of life;Questionnaires;recruit;Refractory;Relapse;Research;response;Risk Factors;sedentary lifestyle;Self Assessment;sex;side effect;Sleep;Societies;Stress;Supportive care;survivorship;Symptoms;Technology;Time;Woman

PROJECT_TITLE: Neurocognitive and Patient-Reported Outcomes after Chimeric Antigen Receptor T-Cell Therapy: A Controlled Comparison

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: NARRATIVE Fetal alcohol syndrome disorder (FASD) is a leading cause of intellectual disability in the United States and is due to maternal alcohol consumption during pregnancy. While the neurodevelopmental disruptions caused by prenatal alcohol exposure are diverse, disrupted axonal and dendritic growth (brain wiring) is a consistent finding. In this proposal we test the novel hypothesis that the wiring defects are caused by dysregulation of a tyrosine kinase called Src making this enzyme a target for neuroprotective strategies.

PI_NAMEs: OLSON, ERIC CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Actins;Acute;Adaptor Signaling Protein;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;alcohol research;alcohol response;Alcohols;Axon;axon growth;axonal pathfinding;Biochemical;Biological;Brain;brain control;Cells;Child;cofilin;Critical Pathways;Cytoskeleton;Defect;Dendrites;Development;Disease;Dissection;Dose;Elements;Embryo;Enzymes;Ethanol;Ethanol dependence;Etiology;Event;fetal;Fetal Alcohol Exposure;Fetal Alcohol Syndrome;Future;Genetic;Genetic Predisposition to Disease;Genetic study;glycosylation;Goals;Golgi Apparatus;Growth;In Vitro;in vivo;Intellectual functioning disability;Knock-out;Ligand Binding;Ligands;Live Birth;Location;maternal alcohol use;Membrane;Methodology;migration;Molecular;Molecular Target;Morphology;Multipolar Neuron;Mus;Nervous System;Neuronal Differentiation;Neurons;neuroprotection;novel;Phase;Phosphorylation;Phosphotransferases;Positioning Attribute;postnatal;prevent;Protein Dephosphorylation;Protein Tyrosine Kinase;Proteins;receptor;receptor binding;Receptor Protein-Tyrosine Kinases;Reelin Signaling Pathway;Research Personnel;response;Role;Signal Pathway;Signal Transduction;Site;src-Family Kinases;Structure;synaptic function;Synaptic plasticity;Syndrome;Teratogenic effects;Testing;Tyrosine Phosphorylation;United States;white matter

PROJECT_TITLE: Ethanol-induced disruption of  kinase signaling pathways in brain development


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proper function of neuronal circuits critically depends on the ability of neurons to identify their correct synaptic partners. In this proposal, I identified the extracellular matrix glycoprotein nephronectin (Npnt) as a candidate for mediating synaptic specificity in retinotectal circuits and aim to understand its role in retinal ganglion cell subtype laminar targeting and synaptic choice. By uncovering new molecular cues that direct synaptic specificity within mammalian circuits, my study offers insights to inform therapies to regenerate these circuits in response to ocular and neurodegenerative diseases.

PI_NAMEs: TSAI, NICOLE Y (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Afferent Neurons;Anatomy;Axon;axon growth;axon guidance;Binding;Biochemical;Biological Assay;Biological Models;Brain;Cell Adhesion;cell type;Cells;Central Nervous System;comparative;Cre driver;Cues;Data;Dendrites;Deposition;Development;differential expression;EGF gene;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Eye diseases;ganglion cell;Genetic;genetic manipulation;Glycoproteins;Hippocampus;In Vitro;in vitro Assay;in vivo;insight;Integrin Binding;Integrins;Kidney;Maps;Measures;Mediating;Molecular;Molecular Profiling;Mus;Natural regeneration;nephronectin;Nervous System;Neurodegenerative Disorders;neuronal circuitry;Neurons;patch clamp;Peptides;Phenocopy;Positioning Attribute;postsynaptic;preference;Process;Proxy;receptor;Research;response;Retina;Retinal Ganglion Cells;retinotectal;Rodent;Role;screening;Series;Signal Transduction;single-cell RNA sequencing;Skin;Specific qualifier value;Specificity;Spinal Cord;Stereotyping;superior colliculus Corpora quadrigemina;Surface;Synapses;synaptogenesis;System;Testing;vision development;Work

PROJECT_TITLE: Investigating the Role of Nephronectin in Establishing Retinotectal Circuit Specificity


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Traumatic brain injury (TBI) causes long-lasting effects on the brain and body characterized by progressive neurodegeneration and chronic inflammation, respectively. The proposed studies will investigate the bidirectional impact of TBI on bone marrow and aim to reveal how changes in the immune system accelerate aging and brain injury. The determination of hematopoietic stem/progenitor cells and bone marrow-derived leukocytes as causal factors of neurological impairment will dramatically improve our understanding of the neuro-immune axis, provide means for improving diagnostics, and open up new windows of treatment for TBI survivors.

PI_NAMEs: RITZEL, RODNEY  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Acute;Affect;age acceleration;age related;aged;antioxidant therapy;Antioxidants;Behavior;Blood Cells;bone health;Bone Marrow;Bone Marrow Cells;Brain;Brain Injuries;Burn injury;career;career development;Cell Physiology;cell type;Cells;central nervous system injury;Chimera organism;Chronic;Chronic Brain Injury;Chronic Phase;Chronic stress;Clinical;Clinical Research;Cognition;Communication;controlled cortical impact;coping;Cysteine;cytokine;Death Rate;Diagnostic;Disease;Disease Progression;DNA Damage;efficacy evaluation;Ensure;Environment;epidemiology study;Epigenetic Process;Event;experience;Experimental Models;experimental study;Failure;Feeling;Female;Flow Cytometry;Follow-Up Studies;Functional disorder;functional outcomes;Generations;Goals;Health;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;high risk;Homeostasis;Hospitals;Immune;immune function;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunity;immunodeficiency;Immunologics;immunosenescence;Impairment;improved;Infection;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;Institution;K-Series Research Career Programs;Leukocytes;Location;Long term disability;Longterm Follow-up;Lung infections;Macrophage;Maintenance;male;Measures;meetings;Mentors;Microglia;middle age;Modeling;Molecular;Multiple Trauma;Mus;Myelogenous;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurologic;neuropathology;novel;novel strategies;Outcome;Oxidative Stress;Patients;Peripheral;Pharmacotherapy;Phenotype;Plasma;Population;Predisposition;premature;prevent;Production;programs;progressive neurodegeneration;Proliferating;Property;Quality of life;Reactive Oxygen Species;Recovery;Regenerative capacity;Rejuvenation;Reporting;Research;research and development;Research Personnel;Research Project Grants;response;Risk;RNA Sequences;Role;secondary infection;Secondary to;Self Correction;self-renewal;senescence;senescent cell;senolytics;Sepsis;Severities;Source;stem;stem cell biology;stem cells;Streptococcus pneumoniae;Stress;Stroke;Survivors;targeted treatment;TBI Patients;TBI treatment;Testing;Therapeutic;Thinking;Time;Tissues;Transgenic Mice;Transplantation;Traumatic Brain Injury;treatment guidelines

PROJECT_TITLE: Mechanisms of Injury-induced Senescence and Immune-sequelae in Chronic TBI

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Urologic Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative: Our goal is to uncover molecular mechanisms underlying myopathic chronic intestinal pseudo-obstruction and megacystis microcolon intestinal hypoperistalsis syndrome, life-threatening forms of visceral myopathy characterized by smooth muscle weakness. Heterozygous missense mutations in gamma smooth muscle actin (ACTG2) are the most common cause of visceral myopathy, but the mechanisms of disease are unknown. Using innovative strategies, including recombinant expression of actin in human cells, advanced quantitative image analysis in human intestinal smooth muscle cells, and visceral smooth muscle- specific differentiation of stem cells, this project investigates mechanisms of ACTG2 mutation-induced visceral myopathy and could lead to new drug screening approaches and novel therapies.

PI_NAMEs: HEUCKEROTH, ROBERT O (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Acute;Adult;Affect;analysis pipeline;Awareness;Biochemical;Biochemistry;Birth;Bladder;Cardiomyopathies;Catheterization;Cell Line;cell motility;Cell Nucleus;Cell Shape;cell type;Cells;Cellular biology;Child;Childhood;Chimeric Proteins;Chronic;Collaborations;colon growth;Congenital Abnormality;Contractile Proteins;Cytoskeleton;Data;Data Set;design;Disease;disease-causing mutation;Drug Screening;Engineering;Functional disorder;Gastroenterologist;Gastrostomy;Gene Expression;Generations;Genes;Goals;Heterozygote;Human;human pluripotent stem cell;Ileostomy;Image Analysis;Impairment;improved;in utero;Individual;Induced Mutation;innovation;Intestinal Pseudo-Obstruction;Intestines;Intravenous;invention;Life;Link;Lovastatin;Medicine;Methods;Microfilaments;Missense Mutation;Molecular;motility disorder;Muscle function;Muscle Weakness;mutant;Mutation;Myopathy;novel therapeutics;nutrition;open innovation;Patients;Persons;Physiological;pluripotent stem cell differentiation;Point Mutation;polymerization;Polymers;Post-Translational Protein Processing;prevent;Property;protein folding;Protein Isoforms;Proteins;quantitative imaging;Recombinants;reduce symptoms;Reporting;Role;scaffold;Sensorineural Hearing Loss;Sirolimus;skeletal;Smooth Muscle;Smooth Muscle Myocytes;stem cell differentiation;stem cells;Structure;success;Symptoms;Syndrome;System;Testing;transcription factor;Transplantation;Uterus;Variant;Vascular Diseases;Visceral;Visceral Myopathies

PROJECT_TITLE: Biochemical and cellular mechanisms linking actin mutations to visceral myopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Diabetes;Genetics;Neurodegenerative;Neurosciences;Nutrition;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Narrative The risk of Alzheimer’s Disease, a form of dementia estimated to affect over 6.2 million people in the U.S., has been linked to diabetes and other forms of cardiometabolic dysfunction. In this proposal, we hope to expand the understanding of the link between diabetes and Alzheimer’s Disease by examining measures of brain health, including functional connectivity. In a diverse and well-characterized cohort of older adults, we will examine how metabolic impairment and vascular dysfunction affect the functional connectivity phenotype of cognitively healthy and AD individuals.

PI_NAMEs: GREEN, ZACHARY DOUGLASS (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;Aging;aging brain;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;amyloid pathology;apolipoprotein E-4;Award;base;Biological Markers;Blood Glucose;blood oxygen level dependent;Blood Vessels;Brain;brain health;Brain imaging;Brain Pathology;Brain region;cardiometabolic risk;cardiometabolism;career;carrier status;Cerebrovascular Disorders;Cerebrum;Classification;Clinical;Cognitive;cohort;Complex;Data;Data Set;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;disorder risk;Doctor of Philosophy;Early Diagnosis;Elderly;epidemiologic data;epidemiology study;Ethnic Origin;Evaluation;Fasting;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Genetic Risk;genetic risk factor;Genotype;Glucose;glucose metabolism;Goals;Health;health data;Heterogeneity;Hippocampus;hyperphosphorylated tau;Hypertension;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Individual;Inflammatory;Latino;Link;lipid metabolism;Measures;Mediating;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;mild cognitive impairment;Monitor;Nerve Degeneration;neural correlate;Neurobehavioral Manifestations;neuroimaging;neuropathology;Neurosciences;non-demented;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Outcome;Pathogenesis;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;Positioning Attribute;potential biomarker;precision medicine;Prediabetes syndrome;Predisposition;recruit;Rest;Risk;Risk Factors;Role;Sample Size;Scientist;Signal Transduction;Site;skills;socioeconomics;Structure;Subgroup;Training;Vascular Diseases;Work

PROJECT_TITLE: Effects of metabolic phenotype on functional connectivity in aging and Alzheimer’s Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The current study aims to develop an intervention that will address alcohol misuse within Latinx sexual minorities by targeting intersectional forms of discrimination (i.e., racism and heterosexism) as there are no behavioral health interventions that address the unique needs of Latinx sexual minorities within the context of alcohol misuse. The study will adapt a Latinx focused motivational interviewing intervention (Culturally Adapted Motivational Interviewing [CAMI]) using an LGBTQ-affirmative intervention adaptation model to develop a culturally-congruent intervention, with community partnerships, to conduct a pilot randomized controlled trial. Findings will provide initial evidence for a novel intervention to decreases alcohol-related problems and misuse for Latinx sexual minorities.

PI_NAMEs: ZELAYA, DAVID G. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adult;Age;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol related problem;alcohol use disorder;Alcohols;Arizona;Award;Behavior;Behavior Therapy;behavioral health intervention;Behavioral Model;binge drinking;cisgender;Client satisfaction;Clinic;Communities;community engaged research;community intervention;community partnership;coping;Data;Development;Discrimination;drinking;drinking behavior;Equipment and supply inventories;Evaluation;evidence base;experience;feasibility testing;Feedback;Frequencies;Future;geographic difference;Goals;Grant;health disparity;health disparity populations;Heavy Drinking;Heterosexuals;Hour;Individual;innovation;intersectionality;Intervention;Interview;Latinx;Latinx population;Lesbian Gay Bisexual Transgender Queer;Link;Manuals;marginalization;Measures;member;men;Mental Health;minority stress;Modeling;Modification;motivational enhancement therapy;motivational intervention;National Institute on Alcohol Abuse and Alcoholism;New England;novel;Outcome;Participant;perceived discrimination;Phase;pilot test;Population;Population Heterogeneity;primary outcome;Process;Protocols documentation;Provider;psychological distress;Public Health;queer;racism;randomized, clinical trials;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Research Project Grants;resilience;response;Risk;Sampling;Science;secondary outcome;Series;sexual minority;sexual minority community;sexual minority group;sexual minority health disparity;sexual risk behavior;skills;Source;Spanish;Spanish/English;Special Population;Strategic Planning;Stress;stressor;substance use;Surveys;telehealth;Testing;therapy development;Time;Training;Translating;Treatment Protocols;trial comparing;trial design;United States National Institutes of Health;Woman

PROJECT_TITLE: Addressing Alcohol Use Health Disparities in Latinx Sexual Minorities: A Culturally Congruent Motivational Intervention Targeting Intersectional Forms of Discrimination

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Exercise is now seen as an effective therapy for many diseases. In pregnant mothers, the benefits of exercise can extend beyond the womb, to affect the health of children long into adulthood. This research develops tools that uses body scanning methods to measure the benefits of exercise in pregnant mice and their offspring.

PI_NAMEs: SON, JUNSEOK ;TEE, SUI SENG  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Adult;Affect;alpha ketoglutarate;APLN gene;Bicarbonates;Biochemistry;Biology;Brown Fat;Carbon;Cells;Child Health;Childhood;Citric Acid Cycle;Clinical Trials;combat;Contrast Media;Data;Detection;Development;Diet;diet-induced obesity;Disease;effective therapy;Ensure;Epigenetic Process;Exercise;experimental study;FAT3 gene;Fatty acid glycerol esters;fetal;Fetal Development;frailty;Fructose;Gene Modified;Goals;Grant;Half-Life;Health;Health Status;healthspan;Hormones;Image;imaging modality;imaging platform;imaging probe;Imaging Techniques;Imaging technology;in vivo;indexing;innovation;Isotopes;Label;Life;Liver;Long-Term Effects;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maryland;mass spectrometric imaging;Maternal Health;Measurement;Measures;Mediating;Medicine;Metabolic;Metabolic Activation;metabolic imaging;Metabolism;metabolomics;Methods;minimally invasive;Modality;Mothers;mouse model;Mus;Muscle;Non-Invasive Detection;non-invasive imaging;offspring;Organ;Outcome;Personal Satisfaction;Physical Exercise;Physiologic pulse;Placentation;Plasma;Positron-Emission Tomography;Pregnancy;pregnant;Pregnant Women;protective effect;Pyruvate;Radioactive;Research;Scanning;sedentary;serial imaging;Signal Transduction;success;Supplementation;Surrogate Markers;Techniques;Technology;Testing;Therapeutic;Three-Dimensional Imaging;Tissues;tool;Translations;Universities;Uterus;Water;western diet;whole body imaging;Work

PROJECT_TITLE: Longitudinal Imaging of Maternal Exercise and Exerkine Effects on Offspring Metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]