NIH_SPENDING_CATS: Bioengineering;Genetic Testing;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The overarching goal of this Tool Development Project is to adapt our RUFUS germline de novo mutation detection software for accurate and sensitive discovery of somatic mutations. We anticipate that this development will lead to a computational mutation detection tool that can facilitate effective and accurate discovery of somatic mutations of all types, lengths, and allele frequencies, and thus substantially contribute to the cataloging and understanding of healthy human somatic mosaicism.

PI_NAMEs: MARTH, GABOR T (contact);UNDERHILL, HUNTER REEVE

PROJECT_TERMS: Adoption;algorithm development;Algorithms;analysis pipeline;Atlases;Automobile Driving;base;Behavior;Benign;Biological;Calibration;Cataloging;Cells;Clinical;Computational algorithm;Computer software;Data;Data Analyses;Data Discovery;Data Set;de novo mutation;design;Detection;detection sensitivity;Development;developmental disease;disease diagnostic;DNA;DNA Sequence;Event;Experimental Designs;Frequencies;Funding;Future;Gene Frequency;Genetic Polymorphism;Genome;Germ Lines;Goals;Human;human tissue;improved;Individual;Inherited;Knowledge;Length;Link;Malignant Neoplasms;Maps;Measures;mosaic variant;Mosaicism;Mutation;Mutation Analysis;Mutation Detection;Noise;novel;Organ;Pathogenicity;Pattern;Performance;Phase;predictive modeling;Rare Diseases;Repetitive Sequence;Resources;Sampling;Sensitivity and Specificity;Somatic Mutation;Specificity;Tissues;tool;tool development;training data;tumor;United States National Institutes of Health;Validation;Variant;variant detection

PROJECT_TITLE: A reference-free computational algorithm for comprehensive somatic mosaic mutation detection


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research will develop and validate an advanced magnetic resonance elastography (MRE) method to provide diagnostic information unavailable using conventional imaging techniques. Recent studies have shown that multiparametric MRE of the liver and spleen has a promising role in detecting and monitoring portal hypertension, a life-threatening problem in patients with chronic liver diseases, as an alternative to invasive hepatic venous pressure gradient measurement. This proposed study’s success will maximize the clinically relevant information provided by hepatosplenic MRE to substantially advance our understanding and ability to diagnose and monitor liver disease progression or regression.

PI_NAMEs: YIN, MENG  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3-Dimensional;Alcoholic Liver Diseases;Animals;Architecture;Assessment tool;bile duct;Biological;Biological Markers;Blood;Cause of Death;Choline Deficiency;chronic liver disease;Cirrhosis;Clinical;clinical practice;Clinical Research;clinical translation;clinically relevant;clinically significant;Data;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diet;Disease Progression;Disease regression;Early Intervention;Effectiveness;Elasticity;elastography;Endoscopy;Esophageal Varix;Esophagogastroduodenoscopy;Esophagus;Etiology;Evaluation;Evolution;experience;Extracellular Matrix;Fibrosis;Frequencies;Goals;hemodynamics;Hemorrhage;Hepatic;hepatocellular injury;High Fat Diet;high risk;Histologic;Human;human subject;Hybrids;Image;imaging biomarker;Imaging Techniques;in vivo;in vivo imaging;Inferior vena cava structure;Inflammation;Intercellular Fluid;interstitial;Intervention;Knowledge;Laboratories;Life;Ligation;Liquid substance;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver inflammation;liver stiffness;Longitudinal Studies;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;mechanical properties;Mechanics;Methods;Modeling;Monitor;Motion;neural network;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Operative Surgical Procedures;Outcome;Pathologic Processes;Patients;Phase;Portal Hypertension;Portal Pressure;preclinical study;predictive modeling;pressure;Prevalence;primary endpoint;Protocols documentation;Radial;Rattus;reconstruction;Research;Research Personnel;response;Risk;Role;screening;secondary endpoint;Severities;skills;soft tissue;Solid;Sorting;Spleen;Steatohepatitis;Stress;success;Techniques;Technology;Test Result;Testing;Therapeutic Intervention;Tissues;Training;Variant;Varicosity;vector;Venous Pressure level;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Noninvasive assessment of portal hypertension and hepatic interstitial pressure with advanced magnetic resonance elastography

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Persistence of the latent HIV reservoir in people living with HIV (PLWH) remains the critical barrier to an HIV cure. Here we will employ novel high throughput single cell strategies to understand the genetic mechanisms that allow HIV infected cells to persist. Understanding how infected cells survive and persist within the body will allow targeted development of HIV cure strategies.

PI_NAMEs: BETTS, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Aftercare;Anatomy;antiretroviral therapy;Apoptosis;ATAC-seq;Binding;Biological Assay;Blood;Blood specimen;CD4 Positive T Lymphocytes;Cell Death;Cell surface;Cell Survival;Cells;Characteristics;chimeric antigen receptor T cells;Clinical Trials;Combination immunotherapy;Data;Detection;Development;DNA;Epigenetic Process;epigenome;Failure;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;HIV;HIV resistance;HIV Seropositivity;Human;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;Individual;Infection;inhibitor;insight;integration site;Interferons;Interruption;latent HIV reservoir;Lymphoid Tissue;Modality;Modeling;multimodality;multiple omics;novel;Outcome;peripheral blood;Persons;phenotypic biomarker;Predisposition;Property;Proteins;Provirus Integration;Proviruses;Resistance;resistance mechanism;Rest;RNA;Sampling;single-cell RNA sequencing;success;Surface;Surface Antigens;System;Testing;Time;Transcript;transcription factor;transcriptome;transcriptomics;Transposase;Viral;Viral reservoir;XCL1 gene

PROJECT_TITLE: Multiomic strategies to assess HIV reservoir persistence


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Dysregulation of melanocytes or melanocyte stem cells leads to diseases that significantly affect an individual's quality of life, ranging from fatal cancers to hyper- and hypo-pigmentation disorders. The goal of this project is to better understand the biology and pathology of these cells through studying the function of a new uncharacterized gene involved. Unlocking the mechanism of this gene will provide new therapeutic targets for manipulating these cells to treat vitiligo, hyper-pigmentation disorders, and melanoma.

PI_NAMEs: SHELLMAN, YIQUN G (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;Aging;Binding;Biochemical;Biological;Biological Process;Biology;Cancer Biology;Cell Cycle Progression;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Disease;gene correction;Genes;Genetic;Goals;Hair;Hyperpigmentation;Hypopigmentation;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Inherited;insight;interest;Kinetics;Knockout Mice;Life;Literature;Maintenance;Malignant Neoplasms;Measurable;Mediating;melanocyte;Melanoma;Mission;Mitotic;Mitotic spindle;Molecular;mouse model;Mus;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;new therapeutic target;novel;novel strategies;Outcome;Pathologic;Pathology;Patients;Pattern;Phenotype;Pigmentation Disorders;Pigmentation physiologic function;Play;Population;premature;Preventive;Proliferating;Proteins;Quality of life;Regenerative Medicine;Regulation;Research;Role;stem cell biology;stem cell model;stem cells;Structure;Study models;Subcutaneous Tissue;Tankyrase;Testing;Therapeutic;three-dimensional modeling;TNKS gene;tool;Ultraviolet Rays;Variant;Vitiligo;Work;young adult

PROJECT_TITLE: Study of melanocyte lineage through SASH1 and associated proteins

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Diabetic cardiomyopathy is an independent risk factor for heart failure, and is characterized by striking changes in cardiac fuel metabolism. Alterations in fuel metabolism may lead to energy deficits in the heart, which can promote or exacerbate cardiac contractile dysfunction. In this proposal, we aim to investigate whether a recently discovered circulating peptide can reverse metabolic changes in the diabetic heart, and lead to improved cardiac function in pre-clinical diabetic cardiomyopathy models.

PI_NAMEs: SCOTT, IAIN  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Acetylation;Acetyltransferase;Address;Advanced Development;analog;Animal Model;Animals;Biochemical;Bioenergetics;blood glucose regulation;Brain;Cardiac;Cardiac Myocytes;Cells;Clinical;Cultured Cells;Data;Defect;Development;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic patient;diabetogenic;dietary control;Disease;Enzymes;Exhibits;fatty acid oxidation;flexibility;functional decline;Functional disorder;Future;G-Protein-Coupled Receptors;Glucose;Goals;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;High Fat Diet;Impairment;improved;In Vitro;in vivo;Incidence;Insulin;Intervention;knock-down;Knockout Mice;Left Ventricular Hypertrophy;Link;Liver;Measurement;mechanical energy;Mediating;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;Modeling;Molecular;Molecular Target;Mus;Nonesterified Fatty Acids;novel;novel strategies;Obesity;Orphan;Output;oxidation;Pathologic;Pathway interactions;peptide hormone;Peptides;Peripheral;Play;pre-clinical;Prediabetes syndrome;Production;Proteins;pyruvate dehydrogenase;receptor;Regulation;Research;Risk Factors;Role;Signal Pathway;Signal Transduction;small molecule;Source;Stress;Testing;Time;Tissues;tool;transmission process;Work

PROJECT_TITLE: Novel strategies to resolve metabolic defects in the diabetic heart

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative We propose to explore whether maternal immune activation results in a cerebrospinal fluid volume increase in subarachnoid space in non-human primate models. If the results of this study will support that such association exists, MRI-detectable cerebrospinal fluid volume increase might be a good biomarker for children whose neurodevelopment was susceptible to maternal immune activation. Early biomarkers allow starting the intervention before behavioral symptoms manifest with better outcomes.

PI_NAMEs: VLASOVA, ROZA  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3 year old;absorption;Address;Adolescent;Adverse effects;Age;Amyloid beta-Protein;analytical tool;Animals;Area;autism spectrum disorder;Behavioral Symptoms;Biological Markers;Brain;brain cell;brain volume;cell growth;Cell Physiology;Cerebrospinal Fluid;cerebrospinal fluid flow;Child;Childhood;Circulation;Clinical;Collection;cytokine;Cytokine Activation;Data;data resource;Data Set;Databases;Development;diagnostic tool;early detection biomarkers;Endotoxins;Etiology;Event;Excision;Exposure to;fetal;Fluids and Secretions;glymphatic system;Growth;Growth Factor;Immune;immune activation;immune function;Immune system;Immunologic Surveillance;in vivo;infancy;Infant;Inflammation;Inflammatory;Injections;insight;Interleukin-6;Intervention;Investigation;large datasets;lateral ventricle;Link;Lipopolysaccharides;Macaca;Macaca mulatta;macromolecule;Magnetic Resonance Imaging;Meningeal lymphatic system;Metabolic;Methods;Modeling;Monkeys;MRI Scans;Nervous System;neural;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuroimaging;neuroimaging marker;neuroinflammation;nonhuman primate;novel;novel diagnostics;offspring;open source;Outcome;Pathway interactions;Pattern;Placenta;Play;postnatal;postnatal period;Predisposition;Pregnancy;prenatal;prenatal exposure;Primates;Procedures;Production;Proteins;Puberty;Public Domains;Publishing;Reaction;Regulation;Research;Rhesus;Role;Sampling;Scanning;secondary analysis;Signal Transduction;Signaling Molecule;Structure;Subarachnoid Space;Surface;synaptogenesis;tau Proteins;Thick;Time;Tracer;wasting;Wisconsin

PROJECT_TITLE: Does prenatal immune challenge result in increased extra-axial CSF volume?

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  The number of older Americans will double in the next 4 decades to nearly 90 million, placing an unprecedented financial and resource burden on the health care system. Exercise has clear and demonstrable physical benefits, but a more precise understanding of how exercise supports cognitive function is essential. Demonstrating definitively that exercise as recommended by public health entities has benefits for cognition would have enormous public health implications, encourage the public to adapt more active lifestyles, and stimulate the development of effective exercise delivery programs.

PI_NAMEs: SZABO-REED, AMANDA N.;VIDONI, ERIC DENNIS (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: active lifestyle;Address;Aerobic;Aerobic Exercise;Age;Age-associated memory impairment;Aging;aging population;Alzheimer's Disease;American;arm;arterial spin labeling;Attenuated;Bioenergetics;Biological;Biological Markers;Blood Chemical Analysis;Blood Platelets;Body Composition;Body fat;Brain;brain health;brain magnetic resonance imaging;Brain region;brain volume;Brain-Derived Neurotrophic Factor;cardiorespiratory fitness;Cerebrovascular Circulation;Cities;Clinical;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive performance;Communities;community setting;comparison control;Consensus;Dementia;Development;Dose;Enrollment;Equilibrium;Exercise;exercise intervention;exercise program;exercise training;experience;Fatty acid glycerol esters;flexibility;functional gain;Functional Magnetic Resonance Imaging;Future;Gait;Goals;group intervention;Health Care Costs;Health education;Health Policy;Healthcare Systems;hippocampal atrophy;Impaired cognition;improved;Individual;Insulin Resistance;Insulin-Like Growth Factor I;Kansas;Knowledge;Life;Link;Maintenance;Measures;Mediating;Modality;mode of exercise;Multi-Institutional Clinical Trial;muscle form;Muscle function;muscle strength;Neuropsychology;older adult;Oxygen Consumption;Participant;Phase;Physical activity;physical conditioning;Physical Exercise;Physical Function;Physiological;Plasma;prevent;programs;Public Health;Quality of life;Randomized;Recommendation;Research;Resistance;resistance exercise;Resources;Rest;Science;Structure;Testing;Translating;United States National Institutes of Health;Walking;Weight Lifting

PROJECT_TITLE: Differential Effects of Exercise Modality on Cognition and Brain in Older Adults


PHR: Stroke remains a common cause of death and disability worldwide. Neutrophils are circulating white blood cells that mediate many aspects of stroke. We will study whether targeting platelet-mediated neutrophil extracellular trap formation reduces neurological damage from stroke, and improves outcomes.

PI_NAMEs: CAMPBELL, ROBERT A (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: 3-Dimensional;Acute;acute stroke;adverse outcome;Affect;Animals;antimicrobial;Aspirin;Binding;Biological Assay;Blood Platelets;Blood Vessels;Brain;Brain Infarction;Brain Ischemia;brain tissue;Cause of Death;Cerebrovascular Circulation;Chromatin;circulating biomarkers;Clinical;cognitive disability;cognitive function;Data;Development;disability;Event;experience;extracellular;Feedback;Female;fighting;Genetic;HMGB1 gene;Human;Impairment;improved;improved outcome;In Vitro;in vivo;Infarction;Infection;Inflammation;Inflammatory;inhibitor;Injury;innovation;Ischemia;Ischemic Stroke;Leukocytes;Location;long term recovery;Longitudinal Studies;male;Mediating;Microbe;microbicide;Middle Cerebral Artery Occlusion;Modeling;Molecular;mortality;Motor;Mus;Nervous System Physiology;Nervous System Trauma;Neurologic;Neurologic Deficit;Neurological outcome;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel therapeutics;Outcome;pathogen;Pathologic;Patients;Pattern;Persons;pharmacologic;physically handicapped;Plasminogen;Platelet Activation;Play;post stroke;Public Health;Reaction;Recovery;recruit;response;Role;scaffold;Site;Stroke;stroke model;stroke outcome;stroke patient;stroke therapy;System;Techniques;Testing;Therapeutic;Thrombectomy;thrombolysis;Thrombosis;thrombotic;thrombotic complications;Thrombus;Tissues;Venous Thrombosis

PROJECT_TITLE: Platelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke Injury

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The project will generate genetic reagents that will allow the study of the function of 2,300 fly genes and their human homologs. The reagents that we propose to generate here will greatly advance our understanding of functions of these genes by providing the most sophisticated tools available in any model system. These tools/reagents also often allow the replacement of the fly gene with its human ortholog, making it possible to study specific human disease-causing variants, including orphan disease variants.

PI_NAMEs: BELLEN, HUGO J (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Alleles;Basic Science;Biological;Biological Models;Brain;Budgets;C-terminal;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complementary DNA;Consensus Sequence;Data;Deposition;design;design and construction;Disease;disease model;disease-causing mutation;DNA;DNA cassette;DNA Insertion Elements;DNA Transposable Elements;Drops;Drosophila genome;Drosophila genus;empowerment;Epitopes;Exons;flexibility;fly;FlyBase;Foundations;functional genomics;Gene Exchanges;Gene Expression;Gene Expression Profile;gene function;Gene Proteins;gene replacement;Gene Targeting;Generations;Genes;Genetic;genetic manipulation;Genotype;Goals;Guide RNA;Homologous Gene;homologous recombination;Human;human disease;Immunoprecipitation;in vivo;Individual;Induced Mutation;Insertional Mutagenesis;Integrase;interest;International;Introns;knock-down;Length;Letters;Libraries;loss of function;loss of function mutation;Maps;Mediating;Medical;Messenger RNA;Methods;Molecular;Muscle function;Mutagenesis;mutant;N-terminal;Nature;Neurons;Oogenesis;Open Reading Frames;Organism;Orthologous Gene;Pathway interactions;Pattern;Peptides;Phenotype;Polyadenylation;premature;preservation;protein distribution;Proteins;Rare Diseases;Reagent;Regulation;Reporter;Research;Research Personnel;Resources;Ribosomes;RNA;RNA Splicing;Side;Signal Transduction;Site;Structure;synaptogenesis;Technology;Testing;Tissues;TNFSF5 gene;tool;Transgenes;Variant;Viral;web site;Yeasts

PROJECT_TITLE: A Comprehensive Resource for Manipulating the Drosophila Genome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE This study will evaluate whether CDC’s National Health and Nutrition Examination Survey (NHANES) provides accurate population-based human biomonitoring levels for seasonal chemicals. It will provide information that will enable CDC to reconsider their sampling logistics to better represent seasonal and regional variations or will enable us to quantify the extent to which NHANES underestimates US population exposures. This, in turn, will make it possible to apply a multiplicative factor to future exposure estimates from NHANES to obtain a more accurate assessment of exposure.

PI_NAMEs: BARR, DANA BOYD (contact);NAIMAN, DANIEL Q.

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Age;Area;Biological Markers;Biological Monitoring;Blood;Blood specimen;Centers for Disease Control and Prevention (U.S.);Chemical Exposure;Chemicals;Collection;Complex;Cross-Sectional Studies;Data;data centers;Data Collection;design;Eligibility Determination;environmental chemical exposure;Ethnic Origin;Evaluation;Exposure to;field survey;Future;General Population;Guidelines;Health;health assessment;health data;Herbicides;Household;Human;Ice;Individual;Insecticides;Interview;Laboratories;Location;Logistics;Measurement;medical examination;National Health and Nutrition Examination Survey;Nutrition Assessment;operation;Outcome;Pesticides;Plasma;Population;population based;Probability Samples;programs;Protocols documentation;Public Health;Publications;Race;Reaction;Reference Values;Reporting;Research;Research Design;response;sample collection;Sampling;Schedule;Seasons;Serum;sex;Site;Techniques;Training;United States National Center for Health Statistics;urinary;Urine;US State;Variant;Weather;weather patterns

PROJECT_TITLE: Does NHANES underestimate true population-based exposures to pesticides? Exploring bias in NHANES human biomonitoring data.

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Precision Medicine;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Childhood obesity is one of the most serious public health challenges because of its harmful consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems. To identify risk factors for childhood obesity at the very beginning of life, we propose to use an innovative metabolomics approach (a high-throughput method for testing metabolites in biofluids) to systematically identify metabolites in the plasma of pregnant women which can predict the risk of childhood obesity. The study findings will significantly contribute to a better understanding of the biological mechanisms underlying the early origins of childhood obesity and the development of early and effective tools for preventing childhood obesity.

PI_NAMEs: ZHAO, QI  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 4 year old;adult obesity;adverse outcome;Affect;African American;Age;Alcohol consumption;American;Beginning of Life;Biological;Biological Assay;Biological Process;biracial;Birth;Blood;Blood specimen;Cardiovascular Diseases;Child;Childhood;Clinical;Clinical Data;cohort;Collection;County;Development;Diet;Dietary Factors;Dietary Practices;Disease;early childhood;early detection biomarkers;effective intervention;Endogenous Factors;Energy Intake;Environmental Exposure;Epidemic;European;Exogenous Factors;fetal;follow-up;Future;Gestational Diabetes;gestational weight gain;Goals;Growth;Health;High Prevalence;Individual;innovation;insight;Intervention;Investigation;Learning;Life Cycle Stages;life span;Life Style;Link;liquid chromatography mass spectrometry;Live Birth;maternal condition;Measurement;Measures;Mediation;Mendelian randomization;metabolomics;Methods;modifiable risk;Molecular Weight;Morbidity - disease rate;Mothers;Neurocognitive;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;Obesity Epidemic;obesity in children;obesity risk;offspring;offspring obesity;Outcome;Overweight;overweight child;Participant;personalized intervention;Physiological Processes;Plasma;predictive marker;Pregnancy;Pregnant Women;prenatal;prenatal risk factor;prepregnancy obesity;prevent;Prevention;psychologic;Public Health;Race;rapid growth;rapid weight gain;recruit;Risk Factors;risk prediction;Sampling;Second Pregnancy Trimester;sex;Smoking;Technology;Tennessee;Testing;Third Pregnancy Trimester;Time;Tissues;tool;Translational Research;Umbilical Cord Blood;Umbilical cord structure;Validation;Visit;Weight Gain

PROJECT_TITLE: Prenatal Longitudinal Metabolomics Profiling for Early Childhood Growth Trajectories and Obesity Risk in a US Biracial Birth Cohort


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: BIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: The proposed research develops and applies a new class of Multiple Synonymous Substitution models that include both selected and neutral synonymous changes in estimates of evolutionary change. Our hypothesis is that the current definition of what constitutes neutrally evolving sites is importantly wrong in that it biases the estimation of selective forces (by underestimating the rates of neutral changes), and that improved estimates without that bias will provide significantly better and more accurate understanding of the action of natural selection in a broad array of evolutionary contexts. We will apply and validate these methods across a broad array of taxa and develop news comparative and population genetic tests of selection.

PI_NAMEs: HEY, EMANUEL  (contact);POND, SERGEI L KOSAKOVSKY

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Amino Acid Substitution;Amino Acids;Back;Biological;Classification;Code;Codon Nucleotides;comparative;Computer software;Control Groups;Data;Factor Analysis;Failure;fitness;Frequencies;Genes;Genetic;Genetic Programming;Genetic Techniques;genetic testing;Genetic Variation;genomic data;Genomics;improved;Individual;internal control;invention;Lead;Learning;Life;Measures;Methods;model development;Modeling;molecular clock;Natural Selections;news;novel;novel strategies;Pattern;Phylogenetic Analysis;Population;Population Genetics;Population Sizes;predictive modeling;Proteins;Publications;Research;Research Personnel;Sampling;Sequence Alignment;Sequence Homologs;Site;Speed;Taxonomy;Testing;tool;Validation;Variant;web app

PROJECT_TITLE: Reinventing dN/dS and the study of natural selection

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project studies how regulating factors called sirtuins influence defense against TB. Sirtuin levels fall when immune cells are infected with the germ that causes TB, which helps in the immediate defense against TB but can lead to lung damage during chronic infection. New knowledge gained by this project will increase knowledge about the role of sirtuins in TB and could identify new treatments to hasten TB cure and improve lung heath by restoring the proper balance of sirtuin activity during antibiotic treatment.

PI_NAMEs: KORNFELD, HARDY  (contact);SINGHAL, AMIT

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Address;aerobic glycolysis;Aerosols;Agonist;Animal Model;Antibiotic Therapy;antimicrobial;ATP Citrate (pro-S)-Lyase;Cause of Death;Cell Death;Cell Line;Cells;chronic infection;Citric Acid Cycle;cytokine;Data;Deacetylase;Deacetylation;Development;Dose;Down-Regulation;Electron Transport;Engineering;Environment;Enzymes;Epigenetic Process;Equilibrium;Event;experimental study;falls;Family;Fibrosis;Genes;Genus Mycobacterium;Germ;Glycolysis;healing;Hexokinase 2;Histone Acetylation;Histones;Homeostasis;Host Defense;Hypoxia Inducible Factor;Immune;Immunity;Impairment;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;inhibitor;interest;Interleukin-1;Knockout Mice;Knowledge;Left;Lesion;Ligands;Link;Lung;lung health;lung injury;lung preservation;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Mitochondria;Modeling;Mus;Mycobacterium tuberculosis;Myelogenous;Necrosis;Nicotinamide adenine dinucleotide;Outcome;overexpression;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Performance;permissiveness;PPAR gamma;Predisposition;Process;Production;promoter;Publishing;Pulmonary Inflammation;Pulmonary Pathology;Pulmonary Tuberculosis;Reactive Oxygen Species;Receptor Signaling;Repression;Resolution;respiratory;response;Role;sensor;Severities;Severity of illness;sex;single-cell RNA sequencing;SIRT1 gene;Sirtuins;Starvation;Sterilization;Stress;Survivors;Testing;Time;Toll-like receptors;transcription factor;transcriptomics;Treatment outcome;Tricarboxylic Acids;Tuberculosis;tuberculosis treatment;Warburg Effect

PROJECT_TITLE: Sirtuins and Host Metabolism in TB Pathogenesis and Treatment

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Prevention;Rare Diseases;Stroke

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Survivors of immune thrombotic thrombocytopenic purpura (iTTP) experience significant neurologic morbidity including cognitive impairment and high rates of stroke that impact their functioning and quality of life. We have identified that silent cerebral infarction (SCI) or ‘silent stroke is common in iTTP survivors and contributes to cognitive impairment. By examining whether SCI progress during iTTP clinical remission and increase the risk of future stroke and testing whether novel ‘microthrombi targeting’ treatments for acute iTTP (caplacizumab) reduce the risk of SCI and associated cognitive impairment, this study will identify the optimal timing, targets, and clinical endpoints for interventions to alleviate the devastating neurologic sequelae of iTTP.

PI_NAMEs: CHATURVEDI, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;ADAMTS;Address;Adult;Age;Animals;Award;biobank;Biological Markers;Blood Vessels;Brain Ischemia;brain magnetic resonance imaging;Cerebral Infarction;Cerebrovascular Disorders;Characteristics;chronic stroke;Clinical;clinical care;clinical remission;Clinical Research;clinical research site;Clinical Trials;Cognitive deficits;cognitive testing;cohort;cost effective;Coupled;Data;design;Development;Disease;Disease remission;economic impact;Enrollment;Evaluation;Exhibits;experience;Future;General Population;Goals;high risk;Hour;Hypertension;Immune;Immunosuppression;Impaired cognition;improved;Incidence;Individual;Infrastructure;Intervention;Intervention Trial;ischemic lesion;Lesion;Life;Long-Term Effects;Magnetic Resonance Imaging;Measurable;Minnesota;modifiable risk;Morbidity - disease rate;Natural History;Neurologic;Neurologic Deficit;Neurologic Symptoms;Neurological outcome;novel;Observational Study;Ohio;Outcome;Patients;Peptide Hydrolases;Plasma Exchange;population based;Preparation;Prevalence;prevent;prospective;Prospective Studies;Protocols documentation;Quality of life;Rare Diseases;Recovery;relapse prevention;Reporting;Research;response;Risk;Risk Factors;Risk Reduction;Role;Sampling;Severities;Site;Social Impacts;Stroke;stroke risk;Survivors;Syndrome;Testing;Thrombosis;thrombotic;Thrombotic Thrombocytopenic Purpura;Thrombus;Time;United States;Universities;vascular risk factor;Visit;von Willebrand Factor;Work

PROJECT_TITLE: Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Q (O1)]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE The results of this research will yield an improved understanding of how a common condition termed “femoroacetabular impingement syndrome” alters the shape and biomechanics of the hip and will determine if these data are associated with image-based measurements of the structure and composition of hip cartilage and labrum health provided by quantitative magnetic resonance imaging. Our findings should offer more direct evidence linking hip anatomy and biomechanics with biochemical changes associated with hip osteoarthritis.

PI_NAMEs: ANDERSON, ANDREW EDWARD (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;acetabulum;Anatomy;Arthrography;Biochemical;Biomechanics;bone;Cartilage;Clinical;clinical decision-making;clinical diagnostics;cohort;Collagen;Control Groups;Cross-Sectional Studies;Data;data modeling;Decision Making;Defect;Deformity;Degenerative polyarthritis;density;disability;Disease;Early Diagnosis;Elements;Exhibits;Failure;Femur;femur head;Fluoroscopy;Functional disorder;Funding;Future;Health;High Prevalence;Hip Osteoarthritis;Hip Pain;Hip region structure;Image;imaging biomarker;improved;in vivo;Individual;Joints;kinematics;Lesion;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Modeling;Morphology;Motion;Neck;osteochondral tissue;Pain;Parents;pathomechanics;Patients;Pattern;Persons;Physiological;Positioning Attribute;predictive marker;Proteoglycan;Recruitment Activity;Research;Resolution;Risk;Risk Factors;Role;Shapes;soft tissue;Source;Stress;Structure;Symptoms;Syndrome;Testing;theories;Time;Tissues;Water

PROJECT_TITLE: Quantitative magnetic resonance imaging in patients with femoroacetabular impingement syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Patient Safety

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Urine output tracking is an essential clinical practice for detecting and treating fluid imbalance in heart failure patients. However, urine output data are typically obtained from collection vessels, which are error-prone due to the manual nature of vessel handling and patient non-compliance. Here, we will develop a toilet-based device, designed specifically for the hospital setting, that will enable automatic, accurate, and timely tracking of patient urine output to enable physicians to more effectively manage volume overload in heart failure patient and avoid the use of indwelling urinary catheters.

PI_NAMEs: DAVID, LAWRENCE ANTHONY (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: 2019-nCoV;Acquired disability;Acute;Adoption;Adverse effects;Biomedical Engineering;Biometry;Blood;Bone Marrow Transplantation;Cardiology;Cardiovascular system;Catheters;Client satisfaction;Clinical;Clinical Management;clinical practice;Clinical Trials;cohort;Collection;Communication;Congestive Heart Failure;Data;Data Reporting;data standards;design;Development;Devices;Diagnostic;Discipline of Nursing;Disease;Diuretics;Dose;Excretory function;Feces;Fluid Balance;Focus Groups;Generations;Goals;Hazardous Chemicals;Heart;Heart failure;Home;Hospital safety;Hospitalization;Hospitals;Human Volunteers;Image;improved;Inpatients;Intake;Kidney Failure;Length of Stay;Liquid substance;Lung;Malnutrition;Manuals;Measurement;Measures;Medical;Medical Records;Methodology;Modification;Monitor;National Heart, Lung, and Blood Institute;Nature;Nurses;Output;pathogen;Patient Care;Patient Monitoring;Patient Noncompliance;patient population;Patients;Performance;Physicians;Positioning Attribute;product development;prototype;Provider;Reporting;Risk;satisfaction;sensor;Sepsis;simulation;standard of care;Surveys;Technology;Test Result;Testing;Time;Transplant Recipients;Urethra;urinary;Urination;Urine;usability;Validation;Walking;wasting;Work;Workload

PROJECT_TITLE: Transforming Urine Output Tracking in Hospitalized Heart Failure Patients

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Skin Cancer;Women's Health Research

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Macrophages, a component of our immune system, have a paradoxical role in cancer – they can promote metastasis. We previously discovered that macrophages spill their internal contents into cancer cells during metastasis, but what is the functionally important information in the contents? We recently discovered that mitochondria are transferred, and we seek to answer how thieving even small amounts of mitochondria can drive big changes in cancer cell metastasis.

PI_NAMEs: ROH, MINNA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Automobile Driving;Behavior;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;carcinogenesis;cell behavior;Cell Communication;Cell Physiology;Cell Proliferation;Cells;Coculture Techniques;Collaborations;Communication;Communities;Cues;Cytoplasm;Darkness;Development;Electron Microscopy;Event;Exhibits;experimental study;extracellular;Future;Generations;Global Change;Goals;Homeostasis;Human;imaging approach;Immune;Immune system;Immunotherapy;In Vitro;in vivo;Injections;knock-down;Lateral;light microscopy;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Metabolic;Metastatic Melanoma;Mitochondria;Morphology;mouse model;Neoplasm Metastasis;neoplastic cell;Organelles;Pathway interactions;Phenotype;PIK3CG gene;Play;Population;Positioning Attribute;Primary Neoplasm;Process;Proliferating;Reactive Inhibition;Reactive Oxygen Species;receptor;Reporting;Resolution;Respiration;response;Role;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Solid Neoplasm;Source;Stromal Cells;Structure;System;Testing;tumor;tumor microenvironment;Tumor-associated macrophages;tumorigenic;Utah;Visualization;Zebrafish

PROJECT_TITLE: Mitochondrial lateral transfer during metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Project Narrative Lower limb amputations are debilitating injuries that result in impaired mobility with a majority developing secondary musculoskeletal impairment and pain that further impacts function. A novel surgical technique that restores the dynamic coupling between agonist and antagonist muscles improves proprioception and the ability to actively control residual limb muscles with the goal being to control muscle-driven prostheses. This proposal aims to determine if there are near-term functional benefits of this surgical technique when using a conventional prosthesis.

PI_NAMEs: BUTOWICZ, COURTNEY M. (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Acceleration;active control;Adopted;Affect;Age;Agonist;Amputation;Ankle;antagonist;Biomechanics;Brain;Central Nervous System;cohort;Coupled;Coupling;Data;Deceleration;design;Electromyography;Esthesia;experimental study;Failure;fall risk;falls;functional improvement;functional outcomes;Gait;Gastrocnemius Muscle;Goals;Hip region structure;Impairment;improved;Injury;innovation;joint mobilization;kinematics;Knee;limb amputation;limb loss;Limb structure;Link;Locomotion;Longitudinal Studies;Lower Extremity;Measures;Mechanics;Mechanoreceptors;Mobility decline;Motor;Movement;Muscle;Musculoskeletal;Musculoskeletal Pain;neuroprosthesis;novel;Operative Surgical Procedures;Outcome;Pain;Patient Self-Report;Patients;Perception;Persons;Phantom Limb;Population;Positioning Attribute;Proprioception;prospective;Prosthesis;prosthesis control;psychologic;Reaction Time;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Relaxation;Reporting;residual limb;response;satisfaction;Sensory;sex;social;Speed;standard of care;Standardization;Stretching;Techniques;Testing;tibialis anterior muscle;Time;Toes;Translating;treadmill;Walking;walking speed;Work

PROJECT_TITLE: Quantifying Locomotor Outcomes with Agonist-Antagonist Myoneural Interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (57)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: This proposed proof of concept (POC) project seeks to consolidate and harmonize neuroimaging and fluid biomarker data from two large, prospective, longitudinal studies in Service Members and Veterans (SMVs). In concert with related POC proposals, we will integrate this data into a unified dataset, and create infrastructure and validate methodology which will be later applied to additional datasets. This work will allow examination of the use of biomarkers in identifying factors that can improve diagnosis, prognosis, and response to treatment in order to improve total brain health in Veterans. This line of research will create the platform essential to personalize the care provided to SMVs by leveraging multiple levels of data in an integrative manner, thereby allowing for a better understanding of individual variations that shape recovery from TBI and associated comorbidities, and lead to the development and maintenance of chronic symptoms. This allows us to both prevent risk, and to provide novel interventions based on improved understanding of integrative mechanisms.

PI_NAMEs: WILDE, ELISABETH A (contact)

PROJECT_TERMS: Address;analytical method;Area;Behavioral;Big Data Methods;Biological Assay;Biological Markers;Brain;Brain Diseases;brain health;Brain Injuries;Caring;Center for Translational Science Activities;Characteristics;Clinical;clinical practice;clinically relevant;Cognitive;cohort;Collaborations;combat;comorbidity;Computer software;Data;Data Aggregation;Data Analyses;data curation;data dissemination;Data Element;data harmonization;data integration;data resource;data reuse;Data Set;deep learning algorithm;Development;Diagnosis;Diagnostic;Diffusion;Elements;Ensure;experience;Factor Analysis;FAIR principles;functional outcomes;Funding;Future;Genetic Markers;Goals;Health;Heterogeneity;Image;imaging biomarker;improved;Incidence;Individual;individual variation;information gathering;Infrastructure;Injury;insight;Interdisciplinary Study;Intervention;Iraq;Knowledge;large datasets;Liquid substance;Long-Term Effects;Longitudinal cohort study;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;Maintenance;Measurement;Mediator;Mental Depression;Mental Health;method development;Methodology;Methods;Military Personnel;Morbidity - disease rate;multimodal data;multimodality;multiple omics;neuroimaging;neuroimaging marker;Neuropsychology;novel;Outcome;Outcome Measure;outcome prediction;Pain;Participant;Patients;persistent symptom;personalized care;physical conditioning;Physiological;Population Characteristics;Post-Traumatic Stress Disorders;Predisposition;preservation;prevent;Prognosis;protein biomarkers;Psychological Impact;Quality of life;Recovery;Reproducibility;Research;Research Support;Rest;Risk;Risk Factors;Sample Size;Sampling;service member;Severities;Shapes;Site;Sleep disturbances;social health determinants;Source;Standardization;Statistical Methods;stress disorder;stressor;suicidal;Symptom Burden;Symptoms;technique development;Techniques;Training;Transcend;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment response;United States;Veterans;Work

PROJECT_TITLE: Total Brain Diagnostics (TBD): Examining the Impact of Fluid and Neuroimaging Biomarkers on Outcomes after TBI

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Disability Research;Pain Research;Pediatric;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Female manual wheelchair users experience shoulder pain and pathology at far greater rates than males. This proposal seeks to reveal sex-specific mechanisms underlying shoulder pain by quantifying the effects of wheelchair use in childhood and adolescence on (Aim 1) glenohumeral muscle morphology, (Aim 2) scapula shape, and (Aim 3) static and dynamic scapular kinematics. The proposed research is critical to the development of updated wheelchair use guidelines as well as sex-specific targeted interventions for the early detection, prevention, and rehabilitation of shoulder pain and pathologies.

PI_NAMEs: LEONARDIS, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: 3-Dimensional;Accounting;acromioclavicular joint;Acromion;Address;Adolescence;Adult;Adult women;Age;Anatomy;arm;Automobile Driving;Bilateral;biomechanical model;bone;Bone Growth;Cardiovascular Diseases;Childhood;Clinical;Couples;Data;deltoid muscle;Development;disability;Early Diagnosis;Early Intervention;emerging adult;Ensure;Equilibrium;Equity;Etiology;Exercise;experience;Female;follow-up;Foundations;Goals;Guidelines;Image;indexing;Individual;insight;Intervention;joint destruction;Joint structure of shoulder region;kinematics;Knowledge;Life;lifetime risk;Magnetic Resonance Imaging;male;Manual wheelchair;Measurable;Measurement;mechanical drive;Mechanics;Medical;Morphology;Motion;Motor;Muscle;Musculoskeletal;Musculoskeletal structure;Nature;Outcome;Pain;Pain interference;Participant;Pathology;Patient Outcomes Assessments;Patients;Physical activity;Posture;preservation;Prevalence;Prevention;Quality of life;Recommendation;rehabilitation paradigm;Rehabilitation therapy;Research;Rest;Risk;Role;Rotator Cuff;scapula;Severities;sex;Shapes;Shoulder;Shoulder Pain;Tendinopathy;Testing;Training;transition to adulthood;Update;Upper Extremity;Wheelchair propulsion;Wheelchair user;Wheelchairs

PROJECT_TITLE: Quantifying Sex-Specific Musculoskeletal Adaptations to Wheelchair Use in Childhood and Adolescence


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness

ORG_CITY: LAINGSBURG

ORG_NAME: ENSPIRED SOLUTIONS INC.

ORG_STATE: MI

PHR: PROJECT NARRATIVE The widespread contamination of drinking and other water sources with per- and polyfluorinated alkyl substances (PFAS) represents an urgent public health issue due to adverse health effects associated with PFAS exposure. The current strategy of removal through adsorption or filtration does not fully address the problem and leads to further spread of PFAS in the environment. When paired with PFAS capture on adsorbents, the micelle- accelerated photoactivated reductive defluorination technology developed at Enspired Solutions can provide a safe, efficient and cost-effective approach for on-site PFAS capture and permanent destruction.

PI_NAMEs: WANG, MENG  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: absorption;Acceleration;Accreditation;Acids;Address;Adsorption;analytical method;base;Benchmarking;Benign;Blood;Businesses;Carbon;carbon compound;Certification;Charge;Chemicals;Cholesterol;commercialization;Complex;contaminated water;Corn starch preparation;cost;cost effective;cost estimate;Dose;drinking;drinking water;electron donor;Electron Transport;Electrons;energy efficiency;Environment;Evaluation;Excision;Exposure to;Filtration;Fluorides;Fluorine;Formulation;Generations;Government;ground water;Health;Hydration status;Immune;Incineration;Individual;Industrialization;Industry Standard;innovation;Ion Exchange Resins;Laboratories;Legal patent;Link;Maintenance;Malignant Neoplasms;Manufacturer;Marketing;Measures;media use;Micelles;Military Personnel;Monitor;Natural regeneration;Oxygen;perfluorooctanoic acid;Persons;Phase;Plant Resins;Poison;Pollution;Poly-fluoroalkyl substances;product development;programs;Public Health;Reaction;Regenerative capacity;remediation;Research;Sampling;Site;Source;success;Surface;surfactant;Suspensions;System;Technology;Testing;Time;Toxic effect;Treatment Cost;ultraviolet;Ultraviolet Rays;United States Environmental Protection Agency;US State;wastewater samples;wasting;Water;water treatment;Woman

PROJECT_TITLE: Advanced Water Treatment System for On-Site PFAS Capture and Destruction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (13)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Glioma stem cells (GSCs) form a minority cell population within the human brain cancer glioblastoma (GBM) that is responsible for treatment resistance, progression and uniform lethality within 2 years or less. Since it has proven very difficult to target GSCs with traditional therapies we propose to modulate electrical signaling with a powerful neuroscience tool, optogenetics, to “reprogram” GSCs to less malignant and more treatment responsive states. The demonstration of GSC reprogramming through electrical manipulation will open the door to new therapeutic strategies expected to overcome treatment resistance and improve outcomes for GBM patients.

PI_NAMEs: HORNER, PHILIP J;ROSTOMILY, ROBERT C (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Atlases;Automobile Driving;bioelectricity;Biological Assay;Brain;cancer cell;cancer stem cell;Cell Count;Cell Culture Techniques;Cell Cycle;Cell Death;Cell Proliferation;Cell Reprogramming;Cells;Cellular biology;Cephalic;chemoradiation;Chemotherapy and/or radiation;Chronic;Clinical Trials;culture plates;Data;Development;Effectiveness;Electric Stimulation;Electrophysiology (science);Engineering;Exploratory/Developmental Grant;Future;Gene Expression;Gene Expression Profiling;Genetic;genetic manipulation;Glioblastoma;Glioma;Growth;Halorhodopsins;Histologic;Human;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;interest;Invaded;Investigation;Ion Channel;Light;Lighting;Luciferases;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;Measures;Mediating;Mediator;Membrane Potentials;Methods;migration;Minority;Modeling;Molecular Profiling;Mus;neural;neuroregulation;Neurosciences;novel;novel therapeutic intervention;Operative Surgical Procedures;optogenetics;Patients;Pattern;pharmacologic;Phenotype;Population;Pre-Clinical Model;programs;Proliferating;Property;Radiation therapy;Recovery;Regulation;Reporting;Resistance;Rhodopsin;Role;self-renewal;sensor;Side;Signal Transduction;standard of care;stem;stem cell differentiation;stem cells;stem-like cell;System;Techniques;temozolomide;Testing;Therapeutic;therapeutic target;therapy resistant;Time;tool;traditional therapy;transcriptome sequencing;Translational Research;Treatment outcome;treatment response;tumor;tumor growth;Tumor Tissue;tumor xenograft;Tumor-Derived;Undifferentiated;vector control;voltage;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Patterned optogenetic neuromodulation to reprogram glioma stem cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative The proposed study aims to develop triptonide into the first nonhormonal male contraceptive drug by conducting a series of key experiments that enable first-in-human studies, including safety pharmacology and toxicology studies using rats and dogs, as required by the FDA.

PI_NAMEs: NICKELS, LOGAN ;YAN, WEI  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Biological Assay;Biological Availability;Brain;Caco-2 Cells;Canis familiaris;Cardiovascular system;Central Nervous System;Clinical Trials;Communication;condoms;Conscious;Contraceptive Agents;Contraceptive methods;Cytochrome P450;Data;deep learning;design;Dose;drug candidate;Economic Factors;efficacy validation;Embryonic Development;Enzymes;Epididymis;ethnic diversity;Evaluation Studies;experimental study;Fertility;first-in-human;Funding Mechanisms;Future;good laboratory practice;Heart;Hepatic;Hormones;Human;In Vitro;Industry;insight;Investigational Drugs;Investigational New Drug Application;Investments;Kidney;Liver;Lung;male;Male Contraceptive Agents;Male Genital Organs;Maximum Tolerated Dose;medication safety;men;Metabolic;Molecular;Monkeys;Mus;Nature;Oral;Oral Contraceptives;Organ;Pathologic;Permeability;Pharmaceutical Preparations;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Phase;Phase I Clinical Trials;Phenotype;pill;Play;Population;pre-clinical;Prostate;Rattus;Reaction;Recovery;Religion;Reporting;Research;respiratory;Safety;safety practice;Seminal Vesicles;Series;Sprague-Dawley Rats;Substrate Specificity;Testing;Testis;Toxic effect;transcriptome sequencing;transcriptomics;unintended pregnancy;Vasectomy;Withdrawal;Woman;Work

PROJECT_TITLE: IND-enabling studies to develop triptonide into the first nonhormonal male pill

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-Z (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative The proposal seeks to use a single-strand RNA bacteriophage called Qb to develop calibration standards that will allow increased standardization of SARS-CoV-2 PCR assays. This standardization will allow more accurate clinical decision making and provide a powerful tool for researchers studying SARS-CoV-2 infection to rigorously compare results between clinical and scientific different studies.

PI_NAMEs: KIRBY, JAMES E (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Address;Bacteriophages;Biological Assay;Calibration;Capsid;Characteristics;Clinical;clinical care;clinical decision-making;Code;Communities;comparative;Complement;COVID-19;COVID-19 diagnosis;COVID-19 diagnostic;Data;Decision Making;Detection;detection assay;detection limit;Development;Diagnostic;diagnostic platform;digital;DNA-Directed RNA Polymerase;Engineering;Fluorescence;Genes;Genetic Transcription;Genome;Genome Stability;genomic RNA;Goals;Hybrids;Immunocompromised Host;Individual;Infection;instrument;International;Laboratory Research;Location;Measurement;Methods;Modality;Nasopharynx;Nose;Patients;Phase;Plasmids;Polymerase Gene;Production;Public Health;Reagent;Recombinants;Research Personnel;research study;Residual state;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;RNA;RNA Phages;RNA-Directed RNA Polymerase;Sampling;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;Signal Transduction;Specimen;Standardization;System;T7 RNA polymerase;Testing;Therapeutic;tool;Ultrafiltration;Untranslated RNA;vector;Viral Load result;Virus

PROJECT_TITLE: Development and Characterization of Phage QBeta-Based SARS-CoV-2 RT-qPCR Assay Calibration Standards

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE To maximize the therapeutic effects of transcranial magnetic stimulation (TMS) interventions on poststroke hand function, they must be delivered during poststroke brain states during which TMS most strongly activates the residual corticospinal tract and enhances its transmission. In this project, we will test the feasibility of real-time personalized brain state-dependent TMS in chronic stroke survivors (Aim 1) and establish poststroke hand impairment inclusion criteria for future clinical trials that investigate this promising personalized brain stimulation approach (Aim 2). Results are expected to directly motivate an R01 proposal that evaluates the therapeutic effects of personalized brain state-dependent TMS on poststroke hand motor control.

PI_NAMEs: HUSSAIN, SARA J (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Adult;Brain;Brain Injuries;chronic stroke;Clinical Trials;Corticospinal Tracts;Coupling;Data;Data Set;detection platform;Electroencephalography;Ensure;Exhibits;feasibility testing;Future;Goals;Hand;hand dysfunction;Hand functions;hand rehabilitation;Human;improved;inclusion criteria;indexing;Individual;Intervention;Life;Literature;machine learning classifier;Methods;Modeling;Motor;motor control;Motor Evoked Potentials;motor impairment;motor learning;motor recovery;Muscle;novel;novel strategies;Paresis;Participant;Pattern;post stroke;prevent;Process;Quality of life;Recovery;Rehabilitation therapy;Reproducibility;Residual state;Rest;restoration;Stimulus;Stroke;stroke rehabilitation;stroke survivor;Sum;Synaptic Transmission;System;Techniques;Testing;Therapeutic Effect;Time;Transcranial magnetic stimulation;transmission process;Variant;virtual;Wrist

PROJECT_TITLE: Towards real-time personalized brain state-dependent TMS to enhance poststroke hand rehabilitation


NIH_SPENDING_CATS: Food Allergies;Genetics;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative Early life dysbiosis induce skin barrier dysfunction and changes skin transcriptomic profile which might increase the risk for skin-associated allergic diseases. Topical treatment with a clinically beneficial isolate of commensal bacterium Roseomonas mucosa could protect from barrier dysfunction induced by perinatal dysbiosis.

PI_NAMEs: GHOSH, DEBAJYOTI  (contact);LEWKOWICH, IAN PAUL

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affect;Age;Airway Disease;Allergens;Allergic Disease;Allergic rhinitis;Animals;Antibiotics;Asthma;Atopic Dermatitis;Automobile Driving;Birth;Breast Feeding;cell type;Cells;Cesarean section;Child;Childhood;chronic rhinosinusitis;Clinical;Clinical Trials;clinically relevant;Cohort Studies;commensal bacteria;Cutaneous;Data;Defect;Developed Countries;Development;Disease;disorder risk;Drug Prescriptions;dysbiosis;early life exposure;Economic Burden;Environmental Exposure;epithelial repair;Epithelium;Exposure to;Extrinsic asthma;Farm;Food Hypersensitivity;Functional disorder;Gene Expression;Gene Expression Profile;gene function;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Gram-Negative Bacteria;healthy volunteer;House Dust Mite Allergens;IgE;Impairment;improved;Infant;insight;Life;Link;Lung;Lung Diseases;Measurement;Measures;microbial;microbial colonization;microbial composition;mouse model;Mucous Membrane;Mus;novel;offspring;Outcome;Pattern;Perinatal;perinatal period;Permeability;Population;Predisposition;Prevalence;prevent;Protocols documentation;Public Health;Receptors, Tumor Necrosis Factor, Type II;resident commensals;Resolution;response;restoration;Risk;Risk Factors;Role;Roseomonas;Saline;Sampling;Serum;Signal Transduction;single-cell RNA sequencing;Skin;skin barrier;skin organogenesis;Skin repair;Societies;Surface;Testing;TNF gene;TNFRSF1B gene;Topical application;transcriptome;transcriptomics;Water;Writing

PROJECT_TITLE: Early life dysbiosis, and skin barrier function


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebral Palsy;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Unilateral cerebral palsy is the most common pediatric neurologic disorder of movement and prevents functional independence during early childhood. The goal of the current proposal is to characterize how brain pathways controlling movement adapt to early injury in children with unilateral cerebral palsy, and to examine these patterns in relation to movement deficits. The knowledge gained from this study will provide the foundation for testing future precision-based approaches to neurorehabilitation and will have broad clinical implications for pediatric movement disorders.

PI_NAMEs: FERRE, CLAUDIO LUIS (contact)

PROJECT_TERMS: Affect;Age;Anatomy;Area;Bilateral;Brain;Brain Injuries;Brain Mapping;brain pathway;Cerebral hemisphere;Cerebral Palsy;Cerebrum;Characteristics;Child;Childhood;Childhood Injury;Clinical;Clinical assessments;Contralateral;cortex mapping;Corticospinal Tracts;design;Development;dexterity;early childhood;Effectiveness;Electrodes;evidence base;Exhibits;expectation;Foundations;functional independence;functional near infrared spectroscopy;Future;Goals;grasp;Hand;hand rehabilitation;hand therapy;hemodynamics;Imaging Techniques;Impairment;improved;Individual;Injury;Intervention;Ipsilateral;Knowledge;Lead;Lesion;Life;Location;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Measures;Modeling;Morphologic artifacts;Motor;motor control;Motor disability;motor impairment;Motor Pathways;motor recovery;Movement;Movement Disorders;multimodality;Muscle;Muscle Weakness;Nervous System Disorder;neural;Neuroanatomy;neurological rehabilitation;Neuronal Plasticity;neurophysiology;non-invasive optical imaging;novel;Outcome;Pattern;Performance;Perinatal;Perinatal Brain Injury;personalized intervention;personalized therapeutic;Physiologic pulse;Play;Positioning Attribute;prevent;Recovery of Function;Rehabilitation therapy;Research;Residual state;response;Rest;Scalp structure;Side;skills;standard measure;Standardization;Stratification;Surface;targeted treatment;Techniques;Testing;therapeutic target;Time;tool;Training;Transcranial magnetic stimulation;Treatment outcome;Upper Extremity;Work

PROJECT_TITLE: Multimodal Characterization of Cerebral Reorganization in Children with Unilateral Cerebral Palsy


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BLOOMINGTON

ORG_NAME: DOOR PHARMACEUTICALS, LLC

ORG_STATE: IN

PHR: Narrative Chronic Hepatitis B Virus (HBV) affects 250-300 million people and leads to 800,000 deaths each year, mainly from liver failure and liver cancer. While HBV spread can be controlled by vaccines and chronic HBV can be treated to suppress virus production, there is currently no cure for curative solution to treat HBV. This proposal focuses on developing a new class of antivirals that can lead to a curative solution for HBV.

PI_NAMEs: NAIR, SMITA  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Affect;Agonist;Agreement;American;Anti-viral Agents;anti-viral efficacy;Antineoplastic Agents;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Businesses;candidate selection;Capsid;Capsid Proteins;Cell Culture Techniques;cell injury;Cell Nucleus;Cells;Cessation of life;Characteristics;Chemistry;Chromatin;Chronic Hepatitis B;chronic infection;Circular DNA;Clinical Trials;commercialization;Complement;Complex;compound 30;Cytoplasm;cytotoxic;Defect;design;dimer;DNA;DNA Packaging;dosage;Dose;Double Stranded DNA Virus;ds-DNA;experience;experimental study;Genetic Transcription;Genome;Genomics;Goals;Health;Hepatitis B Virus;improved;In Vitro;Indiana;Industry;industry partner;Infection;invention;Investigational New Drug Application;Legal patent;Libraries;Licensing;Liver;Liver Failure;Malignant neoplasm of liver;Messenger RNA;Nucleic Acids;Organism;Persons;Pharmacologic Substance;Pharmacology;Phase;Preclinical Testing;Production;Qualifying;Reactive Oxygen Species;Research;Reverse Transcriptase Inhibitors;Reverse Transcription;risk mitigation;RNA-Directed DNA Polymerase;Safety;scaffold;Scientist;Small Business Innovation Research Grant;small molecule;Structure-Activity Relationship;Technology;Testing;Toxic effect;Universities;Vaccines;Viral;viral DNA;Viral Genome;Viral Load result;viral RNA;Virion;Virus;Virus-like particle;Work

PROJECT_TITLE: A new class of antiviral directed at HBV capsid protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative As most youth living with HIV (YLH) now survive into adulthood, transition from pediatric to adult-oriented care has become a pressing public health issue with implications for ongoing efforts to end the HIV epidemic (EHE) in the US. With the integration of statewide multilevel data (e.g., electronic health records) from multiple sources, the current study aims to assess the HIV care transition status and identify the barriers and facilitators of successful transition for YLH in South Carolina. The in-depth assessments of the transition status of YLH could help policymakers and HIV care providers improve systems and services to better support YLH as they move from pediatric to adult-oriented HIV care and inform state health department to devise more precise, targeted intervention strategies for YLH, especially those who are socially disadvantaged.

PI_NAMEs: YANG, XUEYING  (contact)

PROGRAM_OFFICER_NAME: LORENZO, ERIC

PROJECT_TERMS: 15 year old;19 year old;Address;Adolescent and Young Adult;Adult;Age Years;aged;antiretroviral therapy;barrier to care;Behavioral;Biological;care outcomes;care providers;Caring;CD4 Lymphocyte Count;Characteristics;Childhood;Clinic Visits;Clinical;Communities;Continuity of Patient Care;County;COVID-19 pandemic;Data;Data Analytics;Data Set;Data Sources;Databases;Death Rate;Development;Diagnosis;Discrimination;Disease;Electronic Health Record;Epidemic;ethnic minority;Ethnic Origin;experience;Failure;follow-up;gender minority community;Geographic Locations;Health;health care availability;Health Personnel;HIV;HIV diagnosis;HIV disparities;HIV Infections;Immunologics;improved;Individual;Intervention;Link;Longitudinal cohort;Machine Learning;machine learning algorithm;marginalization;Measures;Mental disorders;Minority;minority children;Modeling;Morbidity - disease rate;multiple data sources;Outcome;Pediatrics;Perinatal;Persons;Policy Maker;population based;Population Study;Poverty;prevent;Protocols documentation;Provider;Public Health;Qualitative Research;Race;racial minority;Research;Research Personnel;Rural;Sample Size;Sampling;service providers;Services;Sexual and Gender Minorities;sexual minority community;social culture;social disparities;social stigma;social structure;sociodemographics;Socioeconomic Status;Source;South Carolina;substance use;success;System;therapy adherence;Time;United States;Viral;Viral Load result;Youth

PROJECT_TITLE: Transitioning youth living with HIV to adult-oriented care: a statewide population-based study

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (56)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Complex neural circuits in the brain regulate feeding behavior. We recently identified a previously unknown 3- node neural circuit that connects the cholinergic neurons in the basal forebrain to the hippocampus, and then to the hypothalamus, and this circuit suppresses food intake. In the proposed research we will establish the functional relevance of this circuit in the regulation of feeding behavior and how it impacts long-term body weight control.

PI_NAMEs: ARENKIEL, BENJAMIN R;XU, YONG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acetylcholine;Agonist;alpha-bungarotoxin receptor;American;basal forebrain;Body Weight;Brain;Brain region;Cardiovascular Diseases;cell type;Cells;cholinergic;cholinergic neuron;Chronic;combat;comorbidity;Complex;COVID-19;Cues;Data;Development;Diabetes Mellitus;diabetes risk;Diagonal Band of Broca;Eating;Electrophysiology (science);energy balance;Energy Intake;Energy Metabolism;Equilibrium;feeding;Feeding behaviors;Fiber;Food;Food Intake Regulation;Future;Genetic;genetic approach;genetic manipulation;global health;Goals;Hippocampal Formation;Hippocampus;Homeostasis;Hypothalamic structure;Ion Channel Gating;Knowledge;Lateral;Ligands;Malignant Neoplasms;Mediating;Medical;Mental Depression;Modeling;mouse model;Mus;neural circuit;neural network;neurobiological mechanism;Neurons;Neurotransmitters;Nicotinic Receptors;novel;novel therapeutic intervention;Nucleus Accumbens;obese person;Obesity;obesity development;obesity prevention;obesity treatment;Outcome;Output;Overweight;Photometry;Physiological;receptor function;Receptor Signaling;Regulation;Research;Risk Factors;Role;Synapses;targeted treatment;Testing;Viral Vector;Weight;Weight maintenance regimen

PROJECT_TITLE: A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIOR

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE T cells are a part of the immune system able to control tumor growth, but are ineffective in most cancer patients. Our lab has made the groundbreaking discovery that T cells entering tumors experience an extreme response to stress that rapidly shuts down their ability to generate energy and make and process proteins. Our proposal will formally prove that targeting the stress response holds the power to revive essential T cell functions and invigorate tumor control to allow multiple types of immunotherapies to work better for cancer patients.

PI_NAMEs: THAXTON, JESSICA E (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute;acute stress;Adenosine;Affect;Antigens;attenuation;biological adaptation to stress;Biological Assay;Biological Process;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Physiology;Cells;Cellular Stress;chimeric antigen receptor T cells;Chronic;conditioning;CRISPR/Cas technology;Data;disabled;Endoplasmic Reticulum;endoplasmic reticulum stress;Energy-Generating Resources;Enzymes;Exhibits;experience;fatty acid oxidation;Fatty Acids;FDA approved;Functional disorder;Genes;Genetic;Genus Hippocampus;Human;Immune system;Immune System Diseases;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;innovation;Knockout Mice;Lymphocyte Biology;Measures;Messenger RNA;Metabolic;Metabolism;metabolomics;misfolded protein;Modeling;Molecular;Molecular Target;mouse model;mRNA Translation;Mus;neoplastic cell;novel;novel strategies;nutrient deprivation;Organelles;Oxidative Stress;Oxidoreductase;Pathway interactions;Patients;Phosphotransferases;Process;Protein Biosynthesis;Protein Kinase;Protein Synthesis Inhibitors;Proteins;Proteome;Proteomics;proteostasis;repaired;response;ribosome profiling;Ribosomes;Role;Route;Sarcoma;sensor;Shapes;Signal Transduction;Solid Neoplasm;SRE-1 binding protein;Stress;T-Lymphocyte;Testing;transcription factor;Translating;Translational Repression;Translations;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Expoitation of ER Stress Induced Immune Dysfunction to Improve Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-A(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: GREENSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: Narrative PUBLIC HEALTH RELEVANCE: Lipids are a class of biomolecules that are not only a major component of cellular membranes, but they also function as cell signaling mediators. Dysregulated lipid metabolism is associated with Type 1 Diabetes (T1D). Quantitative profiling of lipids in nonobese diabetic mouse – a widely used model organism that shares similar physiology with human T1D, is an important step toward understanding the role of lipids in human T1D development.

PI_NAMEs: ZHANG, QIBIN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Antigens;Autoimmune Diseases;Beta Cell;Biological Process;biological systems;Cell Death;Cells;Cellular Membrane;Clinical;Communities;Complement;Complex;Development;Disease;Dissociation;Etiology;Glycolipids;Glycosphingolipids;Goals;Human;human disease;human model;improved;Inbred NOD Mice;Insulin-Dependent Diabetes Mellitus;interest;Isomerism;Isotope Labeling;Label;lipid mediator;lipid metabolism;lipidome;lipidomics;Lipids;Liquid Chromatography;Measures;Mediating;Mediator;Methods;model organism;Molecular;mouse model;Organism;Ozone;Pathogenesis;Pathologic;Pattern;Peptides;Physiology;pi bond;Positioning Attribute;Proteins;Protocols documentation;public health relevance;Recovery;Reproducibility;Research;Resolution;Resources;Role;Signal Transduction;stable isotope;Structure;Structure of beta Cell of islet;Symptoms;T-Lymphocyte;Techniques;Technology;Tissues;tool;Transcript;two-dimensional;Unsaturated Fats;Variant;Vertebral column

PROJECT_TITLE: Lipidome Remodeling During Development of T1D

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Genetics;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Low milk production is a cause of low breastfeeding rates and infant mortality. Excessive glucocorticoids disrupt lactation. Defining the mechanism by which glucocorticoids modulate alpha-lactalbumin expression, a critical gene in the lactose synthesis pathway, will inform preventative and therapeutic strategies for low milk supply.

PI_NAMEs: SADOVNIKOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acute;Binding;Binding Sites;biological adaptation to stress;Biological Factors;Biology;Birth;Breast;Breast Feeding;career;Cessation of life;Child;chromatin immunoprecipitation;Clinical;Communication;Complex;Corticosterone;Development;Dexamethasone;DNA-Binding Proteins;Dose;effective therapy;Environment;Exclusive Breastfeeding;Foundations;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Glucocorticoid Receptor;Glucocorticoids;Goals;Guidelines;Health;Heterodimerization;hormone regulation;Hormones;Hospitalization;Human Milk;Hydrocortisone;In Vitro;Induction of Apoptosis;Infant;Infant Mortality;insight;Insulin;Knowledge;Lactalbumin;Lactation;lactogenesis;Lactose;Maintenance;Malignant Breast Neoplasm;mammary epithelium;Mammary gland;Maternal Mortality;maternal obesity;maternal stress;Mediating;Medicine;Messenger RNA;Milk;milk production;milk supply;Mineralocorticoid Receptor;Mineralocorticoids;Modeling;Molecular;Mothers;mRNA Expression;Mus;Obesity;Outcome;Pathway interactions;pharmacologic;Phase;Phosphorylation;Physicians;Postpartum Period;premature;prevent;Prevention Guidelines;Prolactin;promoter;Protein Biosynthesis;protein expression;Proteins;Recommendation;Regulation;Repression;Research;Research Personnel;response;Rodent;Role;Scientist;Site;skills;STAT protein;STAT3 gene;Stat3 protein;Stat5 protein;steroid hormone;steroid hormone receptor;Stress;Testing;Therapeutic;Time;Training;Training Programs;Transactivation;Transcriptional Regulation;United States;United States National Institutes of Health;Water Movements;Woman;Women's mortality;Work

PROJECT_TITLE: The role of glucocorticoids in the regulation of alpha-lactalbumin and milk production.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-Y(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: The ApoE protein plays many important roles, including the transport of cholesterol across different tissues and cells and clearance of amyloid β (Aβ) from the brain, and ApoE4 is the major genetic risk factor for Alzheimer's disease (AD). The molecular mechanism of how ApoE4 contributes to AD pathogenesis remains unclear. In this grant application, we propose various experimentation to dissect its crosstalk with a cytokine- mediated transcription factor C/EBPβ.

PI_NAMEs: BENIAN, GUY MARTIN (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 27-hydroxycholesterol;3xTg-AD mouse;Abeta clearance;adipocyte differentiation;Age of Onset;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Animal Model;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Applications Grants;asparaginylendopeptidase;Astrocytes;Back;Binding;Binding Proteins;Biochemical;Biological Assay;Brain;Cardiovascular Diseases;CCAAT-Enhancer-Binding Proteins;Cells;Central Nervous System;Cholesterol;Cholesterol Homeostasis;Complex;Consensus;cytokine;Deposition;Disease Progression;Event;factor C;Family;Fatty acid glycerol esters;Feeds;Future;Gene Family;genetic risk factor;Genetic Transcription;Goals;Human;Inflammatory;innovation;insight;Interleukin-6;Knock-out;Knowledge;LDL-Receptor Related Protein 1;lipid metabolism;Liver;Low Density Lipoprotein Receptor;Macrophage;Mediating;member;Messenger RNA;Molecular;mouse model;Mus;neurofibrillary tangle formation;Neurofibrillary Tangles;Neuroglia;Neurons;Onset of illness;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Peripheral;Persons;Play;Production;promoter;Protein Isoforms;Proteins;receptor;Reporting;Risk;Role;secretase;Senile Plaques;spatiotemporal;tau expression;tau mutation;tau Proteins;Testing;Therapeutic Intervention;Tissues;transcription factor;Transgenic Mice;Up-Regulation;Viral Vector;YY1 Transcription Factor

PROJECT_TITLE: ApoE4 and C/EBP: Mutually Regulate Each Other in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: OVERALL PROJECT NARRATIVE The Cleveland Digestive Diseases Research Core Center (DDRCC) is focused on pathogenic mechanisms of Digestive Inflammation/Tumorigenesis (i.e., inflammatory bowel disease, colon cancer, Barrett’s esophagus, etc.) and Liver Disease/Metabolism (i.e., hepatitis, metabolic syndromes, obesity, etc.), which affect millions of people in the US. By providing state-of-the-art services to DDRCC investigators at two major Cleveland institutions (Case Western Reserve University and the Cleveland Clinic Foundation), the Center fosters multi- disciplinary collaborative research, leading to new discoveries and treatments, thus having a large impact on the health of patients suffering from digestive diseases.

PI_NAMEs: COMINELLI, FABIO  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Address;Affect;Alcoholic Hepatitis;Alcohols;animal imaging;Applications Grants;Area;Award;Barrett Esophagus;base;Basic Science;biobank;biological adaptation to stress;Biological Response Modifier Therapy;Biomedical Research;carcinogenesis;career development;Cirrhosis;Clinic;Clinical;Colitis;colitis associated cancer;Collaborations;Colon Carcinoma;Colorectal Cancer;cost effective;Cost efficiency;Data;design;Development;Digestive System Disorders;digital pathology;Education;Elements;Endoscopy;Environment;epithelial repair;experience;Experimental Models;Faculty;Fostering;Foundations;Funding;Gastrointestinal Diseases;Generations;Genetic Determinism;Grant;Growth;gut dysbiosis;Health;Hepatitis;Histologic;Histology;HIV therapy;Human;Human Resources;Hyperammonemia;Ileitis;Image;Inflammation;Inflammatory Bowel Diseases;innovation;Institution;International;intestinal epithelium;Investigation;Laboratories;Leadership;Liver diseases;liver imaging;Malignant neoplasm of esophagus;medical schools;meetings;member;Mentors;Mentorship;Metabolic syndrome;Metabolism;microbial;Midwestern United States;minority investigator;Mission;mouse model;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Obesity;Occupational activity of managing finances;operation;opioid use;Organoids;Pathogenicity;Patients;Peer Review;Persons;Privatization;Process;programs;Quality Control;Records;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;sarcopenia;Science;Series;Services;Study Section;Surveys;symposium;Technical Expertise;Techniques;Technology;Time;Tissue Banks;Training;Translations;tumorigenesis;U-Series Cooperative Agreements;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Digestive Diseases

PROJECT_TERMS: Administrator;Advisory Committees;Area;Awareness;Back;base;Bioinformatics;Biomedical Research;Budgets;Clinic;Clinical;Collaborations;collaborative environment;cost;cost effectiveness;Data;Databases;Development;Digestive System Disorders;Effectiveness;Elements;Ensure;Evaluation;Event;Faculty;Feedback;Fees;Fostering;Foundations;Funding;Goals;Grant;Grant Review;Growth;Health;Income;Individual;Inflammation;Infrastructure;Institution;interest;International;Investigation;Investments;Leadership;Liver diseases;medical schools;meetings;member;Metabolism;Midwestern United States;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;news;Occupational activity of managing finances;operation;Peer Review;Process;Productivity;professor;programs;Progress Reports;Publications;Publishing;Recovery;Reporter;Reporting;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resources;Series;Services;Strategic Planning;Surveys;symposium;synergism;Time;tumorigenesis;United States National Institutes of Health;Universities;Visit;web site;Work

PROJECT_TITLE: Administrative Core A


PI_NAMEs: PIZARRO, THERESA TORRES (contact)

PROJECT_TERMS: Applications Grants;Area;Award;Awareness;base;Basic Science;career development;Clinical;Collaborations;Communication;Development;Digestive System Disorders;Education;Educational workshop;Electronic Mail;Electronics;Environment;Feedback;Fostering;Funding;Future;Goals;Inflammation;International;Knowledge;lectures;Liver diseases;Medicine;meetings;member;Mentorship;Metabolism;Midwestern United States;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;operation;Organizational Objectives;Paper;Periodicity;Process;professor;programs;Research;Research Personnel;Science;Series;Services;Special Event;Strategic Planning;Study Section;success;symposium;tumorigenesis;United States National Institutes of Health;Update;Visit;web site

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease

PI_NAMEs: FIOCCHI, CLAUDIO  (contact)

PROJECT_TERMS: Adipocytes;Area;Basic Science;bench to bedside;biobank;Biology;Biopsy;Cell Separation;cell type;Cells;Chronic;Classification;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Laboratory Information Systems;Clinical Research;Colon Carcinoma;community center;Constipation;Consultations;Consumption;cost effective;cost effectiveness;Crohn's disease;Data Analyses;design;Diagnosis;Digestive System Disorders;Diverticulosis;DNA;Educational process of instructing;Elements;Epidemiology;Epithelial Cells;Esophagus;experience;Experimental Designs;Familial Adenomatous Polyposis Syndrome;Feces;Flow Cytometry;Foundations;Funding;gastrointestinal;Gastrointestinal tract structure;Genealogy;Generations;Genetic;genomic platform;Genotype;Goals;Human;Human Resources;improved;In Vitro;Individual;Inflammation;Institution;Institutional Review Boards;Intestinal Volvulus;Intestines;Large Intestine;Liver diseases;Logistics;Malignant neoplasm of esophagus;Malignant Neoplasms;member;Mesentery;Metabolism;Methods;Monitor;monolayer;Operative Surgical Procedures;Organoids;patient oriented research;Patients;Performance;Phenotype;Physicians;Process;Research;Research Activity;Research Institute;Research Personnel;Research Priority;Research Project Grants;research study;Resources;Retrieval;Running;Sampling;Scientist;Serum;Services;single cell analysis;Small Intestines;Specimen;success;synergism;System;Time;Tissue Banks;Tissues;Training;Translating;Translational Research;translational study;tumorigenesis;Ulcerative Colitis;Universities

PROJECT_TITLE: Biorepository Core B


NIH_SPENDING_CATS: Biomedical Imaging;Digestive Diseases;Liver Disease

PROJECT_TERMS: animal imaging;Animal Model;animal tissue;Animals;antigen detection;Antigens;Area;Bioluminescence;Clinic;Clinical Research;Collaborations;Computer software;Consultations;cost;cost effective;design;Digestive System Disorders;digital;digital pathology;Disease Marker;Documentation;Education;experience;Experimental Animal Model;experimental study;Fluorescence;Foundations;Funding;gastrointestinal;Goals;Histologic;Histology;Human;Human Resources;Image;Image Analysis;imaging facilities;Imaging technology;Immunofluorescence Immunologic;Immunohistochemistry;in situ imaging;in vivo;Individual;Inflammation;Inflammatory;Investigation;Label;Laboratories;Leadership;Liver;Liver diseases;Magnetic Resonance Imaging;Medical center;member;Metabolic Diseases;Metabolism;Methodology;Methods;Morphology;novel;optical imaging;Pathologist;Pathology;pathology imaging;Positron-Emission Tomography;preclinical imaging;preclinical study;Production;programs;Protocols documentation;Public Domains;Publications;Radiology Specialty;Rapid screening;repository;Research;Research Personnel;Resolution;Retrieval;Roentgen Rays;Scientific Advances and Accomplishments;Services;Signal Transduction;single photon emission computed tomography;Slide;Specimen;Stains;Structure;System;Technology;Technology Transfer;Time;Tissue Banks;Tissue Sample;Tissues;Training;tumorigenesis;tumorigenic;United States National Institutes of Health;Universities;University Hospitals

PROJECT_TITLE: Histology/Imaging Core C


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease

PROJECT_TERMS: 3-Dimensional;Adoptive Transfer;Anesthesia procedures;Animals;Area;Bone Marrow;Breeding;cell type;Chemicals;Chimera organism;chromoscopy;Chronic;Clinic;cohort;Colitis;Colitis associated colorectal cancer;Collaborations;Colonic inflammation;Colonic Neoplasms;commune;Communities;Complex;Consult;Consultations;Core Facility;cost;cost effective;Cost Savings;Couples;CRISPR/Cas technology;Development;Digestive System Disorders;digital;Disease;Education;effectiveness evaluation;Endoscopy;Evaluation;Evolution;experimental group;experimental study;flexibility;Fostering;Funding;Funding Opportunities;gastrointestinal;gene editing technology;Goals;gut inflammation;Hemoglobin;Hepatitis;Hepatocarcinogenesis;Histology;Human Resources;Ileocolitis;Image;imaging capabilities;Immunologics;improved;in vivo;Individual;Inflammation;Inflammatory;Investigation;Joints;Large Intestine;Light;Liver;Liver diseases;liver inflammation;Magnetic Resonance Imaging;Mediating;meetings;member;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Metabolism;Methodology;Methods;Midwestern United States;Modeling;mouse model;Mus;Mutation;nano-string;new technology;Obesity;operation;Pathogenesis;Performance;Peroxidases;preclinical study;Productivity;programs;Proteins;Protocols documentation;Publications;Qualifying;Randomized;Recovery;Reproducibility;Research;research and development;research facility;Research Institute;Research Personnel;Research Project Grants;Research Support;Resolution;Resource Sharing;Resources;RNA;SAMP mouse;Sampling;Service delivery model;Services;Small Intestines;Standardization;Surveys;System;Techniques;Technology;Testing;Tissue Harvesting;Tissues;Training;treatment effect;treatment group;tumor;tumorigenesis;Universities;Visual;Visualization

PROJECT_TITLE: Mouse Models Core D


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

PI_NAMEs: CHAK, AMITABH  (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Award;career development;Categories;Clinic;Colitis;Collaborations;cost;Crohn's disease;Development;Digestive System Disorders;Eligibility Determination;feasibility research;Fostering;Foundations;Funding;Goals;Grant;Inflammation;innovation;Institution;interest;Investigation;Investments;K-Series Research Career Programs;Liver diseases;member;Metabolism;Midwestern United States;minority investigator;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Peer Review;Peer Review Grants;Privatization;Process;programs;Progress Reports;Qualifying;Research;Research Institute;Research Personnel;research study;Resources;Review Committee;Science;Series;skills;Study Section;success;symposium;Talents;Translating;Trust;tumorigenesis;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Pilot and Feasibility Program


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The main goal of the University of Chicago (UChicago) Digestive Diseases Research Core Center for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) is to foster and facilitate interdisciplinary and innovative and patient-oriented research in the field of complex inflammatory digestive diseases, to understand and therapeutically exploit discoveries to improve the health of patients with DD. The C-IID has successfully met its goals of advancing the science and translation of discovery in complex diseases of the bowel. The C-IID is greater than the sum of its parts. It provides strategic vision, cutting-edge, high quality, and cost-effective services and resources, and gives opportunity to current and next generation scientists to flourish in a highly collaborative and productive environment.

PI_NAMEs: CHANG, EUGENE B (contact)

PROJECT_TERMS: analytical tool;Area;Automobile Driving;base;Basic Science;biological development;Biological Sciences;Biology;Biomedical Research;career development;Chicago;Clinical;Clinical Sciences;Collaborations;collaborative environment;Complex;Computational Science;Core Facility;cost effective;curative treatments;Development;Digestive System Disorders;Direct Costs;Disease;Emerging Technologies;empowerment;Environment;Environmental Risk Factor;Extramural Activities;Fostering;Foundations;frontier;Funding;Funding Opportunities;Genetic;Genomics;Goals;gut microbiome;Health;high throughput technology;Immune;Immunologic Factors;Immunology;improved;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;intestinal homeostasis;Intestines;Investments;Life Cycle Stages;member;Metabolism;microbial;microbiome;microbiome research;Midwestern United States;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;novel diagnostics;Paper;Patient Care;patient oriented;patient oriented research;Patients;Preventive treatment;Productivity;programs;Publications;Research;Research Infrastructure;Research Personnel;Resources;response;Science;Scientist;Services;Strategic vision;Structure;Sum;Talents;Technology;Technology Transfer;Therapeutic;therapeutic target;Tissues;Training Programs;Translational Research;Translations;trend;United States National Institutes of Health;Universities

PROJECT_TITLE: Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

PROJECT_TERMS: Achievement;Administrator;Advisory Committees;Area;base;Basic Science;Biological Sciences;Cells;Center for Translational Science Activities;Chicago;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;cost effective;cost effectiveness;Data;Diabetes Mellitus;Digestive System Disorders;Discipline;Educational workshop;Effectiveness;Faculty;Fostering;Gastrointestinal tract structure;Genetic;Genomics;Goals;Grant;Human;Human Resources;Immunologics;Immunology;Inflammatory Bowel Diseases;innovation;Interdisciplinary Study;International;Intestines;Lead;Leadership;meetings;member;Mentorship;microbial;Microbiology;Midwestern United States;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation sequencing;Nursing Faculty;operation;Peer Review;Performance;Play;programs;Progress Reports;Quality Control;Reagent;Recommendation;Reporting;Research;Research Personnel;Research Training;Resource Allocation;Resource Sharing;Resources;Role;sabbatical;Science;Scientist;Services;sound;Strategic vision;synergism;Technology;Technology Transfer;Tissues;Training;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Admin Core


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Thin-film surface microelectrodes (uECoG) are a novel neurotechnology that can detect microseizure events over large areas of the brain at fine resolution. This project seeks to evaluate the potential of uECoG to improve the diagnosis and treatment of neocortical epilepsy by investigating the cellular mechanisms and clinical significance of microseizure events. The results of this project will advance the standard of care for epilepsy diagnosis, and inform the future development of implantable uECoG devices to diagnose and treat a range of neurological disorders.

PI_NAMEs: FRIEDMAN, DANIEL  (contact);PESARAN, BIJAN

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TITLE: Microscale Electrophysiology of Epileptic Cortex - Resubmission - 1

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

PI_NAMEs: BARREIRO, LUIS BRUNO (contact)

PROJECT_TERMS: Address;analysis pipeline;Antibodies;Area;ATAC-seq;Automobile Driving;Back;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Biological Sciences;biological systems;Celiac Disease;Cell Separation;cell stroma;cell type;Cells;Chicago;ChIP-seq;Chromatin;clinical diagnostics;Communities;Complex;Computational Biology;computerized tools;Consultations;Crohn's disease;Data;Data Analyses;Data Collection;data integration;Data Set;data sharing;Detection;Development;diagnostic tool;Digestive System Disorders;Dimensions;Disease;Disease susceptibility;disorder risk;DNA Methylation;Epigenetic Process;epigenomics;experimental study;Flow Cytometry;Fluorescence;gastrointestinal;Gastrointestinal Diseases;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome analysis;genome-wide;genomic data;genomic tools;Genomics;Goals;healing;high dimensionality;Histones;Human;human tissue;Immune;Immunologics;Immunology;Inflammation;Inflammatory Bowel Diseases;Interdisciplinary Study;interest;Investments;Maintenance;Massive Parallel Sequencing;member;Methods;model organism;molecular marker;next generation sequencing;Nucleic Acids;Physiological;Population;Predisposition;prenatal testing;Process;programs;Proteins;Protocols documentation;Regulatory Element;Regulatory Pathway;Research;Research Design;Research Personnel;Resolution;response;Role;Sampling;Series;Services;single-cell RNA sequencing;Sorting;Speed;Standardization;Stimulus;Technology;Therapeutic;Tissue Sample;Tissues;tool;Training;trait;transcriptome;transcriptome sequencing;treatment response;Ulcerative Colitis;Universities;virtual

PROJECT_TITLE: Multiparametric Host Cell Analysis (MHC)