ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: COVID-19 may have long-term effects on violence through an under-appreciated channel: learning loss for children in school, particularly to low-income and minority children, leading the U.S. Secretary of Education to recommend that schools leverage high dosage tutoring - a scalable and reliable policy to increase learning - to address the problem. As previous research has shown a strong positive correlation between education and violence but evidence for actionable educational policies is scarce, we aim to tackle the basic science question of whether education affects violence involvement, as well as the policy question of whether academic remediation can prevent the expected long-term increase in violent crimes and victimization. Our University of Chicago research team in partnership with Chicago Public Schools aims to use several randomized control trials (RCTs) delivering high-dosage tutoring interventions, two of which were carried out in 2013-15 under ideal field conditions and an additional larger-scale trial that is currently underway, linked to administrative longitudinal data on violence-related outcomes (offending and victimization) to produce short- and longer-term experimental evidence of the violence-reducing effects of tutoring delivered at different scales to answer our research questions.

PI_NAMEs: BHATT, MONICA ;LUDWIG, JENS  (contact)

PROJECT_TITLE: RFA-CE-23-004: Experimental Evidence on the Effects of Academic Remediation on Violence


ADMINISTERING_IC: PS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The overall goal of this project is to increase Medical Trust to lessen HIV prevention and treatment inequities experienced by HLMSM. The study will both uncover factors associated to medical mistrust and implement an intervention aimed at increasing medical trust in HIV prevention and care services. If successful, this study may inform future interventions, hence, potentially decreasing HIV inequities experienced by HLMSM.

PI_NAMEs: RAMIREZ-VALLES, JESUS  (contact)

PROJECT_TITLE: RFA-PS-23-006, De Confianza: Creating Medical Trust with Latinx Communities


ADMINISTERING_IC: DE

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Oral squamous cell carcinoma (SCC) has a high recurrence rate that leads to poor patient survival. Tumor progression and recurrence rely on invasion of tumor cells away from the main tumor, so investigating mechanisms responsible for invasion are extremely important for identification of novel therapeutic targets that could improve survival. The objective of this project is to understand how SCC co-opts adjacent ‘normal’ epithelium to promote invasion.

PI_NAMEs: DANELLA, ERIKA BUNNINE (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: activating transcription factor 3;Aftercare;antimicrobial;Bacteria;Bacterial Infections;Binding;Biological;Biological Assay;cancer cell;Cancer Etiology;Cell Line;cell type;Cells;chemical carcinogenesis;Chemicals;cytokine;Data;Down-Regulation;dysbiosis;enhancing factor;Enzyme-Linked Immunosorbent Assay;epidemiology study;Epithelial Cells;Epithelium;Feedback;Genetic;Genetic Transcription;glycoprotein 340;Goals;Human;Immune;improved;In Vitro;in vitro Assay;in vivo Model;Inflammatory;inhibitor;Interleukin-6;Invaded;keratinocyte;Lateral;Lesion;malignant mouth neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Microbe;microbiome;migration;Modeling;Molecular;mouth squamous cell carcinoma;Mus;neoplastic cell;new therapeutic target;Oral;Oral health;oral microbiome;oral pathogen;pathogen;Patients;Periodontal Diseases;pharmacologic;Porphyromonas gingivalis;Predisposition;prevent;Proliferating;Promoter Regions;Protein Secretion;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Recurrence;release factor;Research;response;Role;Saliva;Salivary Glands;Signal Pathway;Signal Transduction;Squamous cell carcinoma;Testing;therapeutic target;transcription factor;Transfection;Transforming Growth Factor beta;tumor;Tumor Cell Invasion;tumor progression;Tumor Suppressor Proteins;Validation;Western Blotting;With laterality

PROJECT_TITLE: Exploring the Role of DMBT1 Suppression in Invasion of Oral Cancer

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Hodgkin's Disease;Human Genome;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Relapsed and refractory Hodgkin lymphoma patients have few treatment options and overall survival remains low. Current genomic technologies struggle with cancers defined by rare malignant cell populations, leaving some cancer types poorly described - Hodgkin lymphoma is one such cancer. This proposal will address these shortfalls by using newly developed technologies and diverse sources of DNA to describe somatic variation and clonal architecture in relapse and refractory Hodgkin lymphoma.

PI_NAMEs: GOMEZ, FELICIA  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Affect;Aftercare;anti-cancer research;Architecture;Automobile Driving;B-Lymphocytes;Bioinformatics;Biological Markers;Biology;biomarker identification;Cancer Biology;cancer cell;cancer genomics;cancer type;cell free DNA;cell type;Cells;Clinical;clinically relevant;cohort;Collection;Data;deep sequencing;design;Development;Diagnosis;Disease;Disease Outcome;DNA;Evolution;exome;exome sequencing;experimental study;Genes;Genome;genome-wide;Genomics;Germ Lines;Goals;Heterogeneity;Hodgkin Disease;improved;innovation;large datasets;Location;lymph nodes;Lymphoma;Malignant - descriptor;Malignant Neoplasms;medical schools;Methodology;Methods;Molecular;Monitor;Morphology;Mutate;Mutation;Mutation Detection;mutational status;Needs Assessment;new therapeutic target;Newly Diagnosed;next generation sequencing;Normal tissue morphology;Outcome;Pathway interactions;Patients;Plasma;Population;Prediction of Response to Therapy;Predictive Factor;predictive marker;Primary Neoplasm;Prognosis;programs;Reagent;Recurrence;Reed-Sternberg Cells;Refractory;Relapse;Research;Resistance;Risk Assessment;Salvage Therapy;Sampling;Signal Transduction;Somatic Mutation;Source;standard of care;Statistical Methods;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapy resistant;tool;Training;treatment response;tumor;Tumor Biology;tumor microenvironment;Universities;Variant;Washington;Western World

PROJECT_TITLE: Deep Sequencing of Relapse and Refractory Hodgkin Lymphoma Genomes: A Study of Tumor Biology and Evolution

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Our collaborative group of scientists and clinicians in India and the United States strive to address global health equity by establishing genomic tools and research in India to diagnosis and treat neurodevelopmental disorders that are lethal or cause lifelong impairments. These resources will be available to patients across the socioeconomic spectrum. Identifying genetic contributions to disease risk in diverse populations will promote reliable genetic diagnosis important for effective treatment.

PI_NAMEs: BIELAS, STEPHANIE LEE (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Adopted;Affect;Alleles;analysis pipeline;Asian ancestry;Benign;biobank;Bioinformatics;Brain;burden of illness;carrier testing;Cell Line;Child;Classification;Clinical;cohort;Collaborations;Communities;Complex;consanguineous family;Country;Data;Data Set;Death Rate;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;disease-causing mutation;disorder risk;Disparity;DNA sequencing;Education;effective therapy;Equity;established cell line;Etiology;Exhibits;exome sequencing;experience;experimental study;Family;Fostering;Founder Effect;Frequencies;Genes;Genetic;genetic approach;genetic disorder diagnosis;Genetic Predisposition to Disease;genetic testing;genetic variant;Genetic Variation;Genomic medicine;genomic tools;Genomics;global health;Goals;Guidelines;Health;health equity;health inequalities;Health Policy;Healthcare;Hereditary Disease;Human Genetics;Human Genome Project;Impairment;improved;Incidence;Income;India;Individual;Inequity;Infant Mortality;Infrastructure;Inherited;insight;Intellectual functioning disability;leukodystrophy;Light;low and middle-income countries;Medical;Medical Genetics;medical schools;Michigan;mitochondrial dysfunction;Molecular;Mutation;Natural History;Neurodevelopmental Disorder;Neurologic;non-genetic;novel;Nutritional;Outcome;outreach;parity;Pathogenesis;Pathogenicity;Patients;Persons;Population;Population Heterogeneity;Prognosis;Public Health;Rare Diseases;Recording of previous events;Recurrence;Research;Research Infrastructure;Resources;Risk;Role;Science;Scientist;socioeconomics;southeast Asian;success;Syndrome;Testing;tool;United States;Universities;Variant;variant detection;web platform;World Health Organization

PROJECT_TITLE: Genetic Diagnosis of Neurodevelopmental Disorders in India


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Our team aims to discover molecular mechanisms by which certain patients with coronavirus disease-2019 (COVID-19) do very poorly. COVID-19 is a pandemic caused by infection with the severe acute respiratory syndrome coronavirus 2, which primarily damages the lungs but can also have devastating effects on the heart and circulation. Data from China, Europe and US indicate that underlying cardiovascular conditions, such as hypertension, diabetes, obesity, and coronary artery disease, lead to higher likelihood of getting COVID-19, more severe disease, and greater risk of death. These conditions are highly prevalent in the Veteran population, yet some Veterans with cardiovascular conditions have poor outcomes while others with similar conditions appear to be resilient. We propose to study blood samples from a bio repository at the Atlanta VA that banks blood left over from routine laboratory tests of COVID-19 patients. We will determine whether specific novel molecular markers in blood can predict susceptibility to poor outcomes and potentially become therapeutic targets.

PI_NAMEs: SEARLES, CHARLES D (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;Address;adverse outcome;African American;African American population;Age;airway epithelium;aminothiol;angiotensin I (1-7);Angiotensin II;Arrhythmia;biobank;Biochemical Pathway;Biological;Biological Markers;biomarker identification;Blood;Blood Banks;Blood specimen;Brain natriuretic peptide;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;cell injury;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;China;Circulation;Clinical;Clinical Data;clinical predictors;clinically relevant;cohort;Congestive Heart Failure;Coronary Arteriosclerosis;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 susceptibility;COVID-19 test;COVID-19 testing;Data;Databases;Development;Diabetes Mellitus;differential expression;Disease;Disease Outcome;Disease Progression;Electronic Health Record;Epidemic;Epigenetic Process;Ethnic Origin;Europe;experience;extracellular;feature selection;Fibrin fragment D;Fibrin split products;Group Hospitalization;Health;Heart;hemodynamics;High Prevalence;high risk;Hospitalization;Hypertension;Immune;immune activation;Immune response;Immunologic Markers;indicated prevention;Infarction;Infection;Inflammation;inflammatory marker;Infrastructure;Interleukin-6;International;Intervention;Laboratories;Lead;Left;Logistic Regressions;lung injury;Measurement;Measures;Mechanical ventilation;Medical center;member;men;Metabolic;Metabolic Pathway;metabolome;metabolomics;Methods;MicroRNAs;military veteran;Modeling;Molecular;molecular marker;Molecular Profiling;mortality risk;multiple omics;Myocardial;myocardial injury;Myocarditis;new therapeutic target;next generation sequencing;novel;novel marker;Obesity;Outcome;Oxidative Stress;pandemic disease;participant enrollment;Pathologic;Pathway interactions;patient registry;Patients;personalized intervention;Pilot Projects;Plasma;Positioning Attribute;precision medicine;predictive modeling;Predisposition;primary endpoint;prognostic;programs;prospective;Proteomics;Protocols documentation;Race;Renin;Renin-Angiotensin-Aldosterone System;repository;Research;Residual state;resilience;Risk;Risk Factors;risk prediction;Role;Sampling;SARS-CoV-2 infection;screening;secondary endpoint;Serum;severe COVID-19;Severity of illness;sex;specific biomarkers;Stretching;systemic inflammatory response;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;thrombogenesis;Troponin I;University Hospitals;Urokinase Plasminogen Activator Receptor;Veterans;Virus Diseases;Work

PROJECT_TITLE: COVID-19: Multi-Omics Approach to Identify Molecular Mechanisms Responsible for Risk and Resilience to Adverse Outcomes


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Spontaneous coronary artery dissection (SCAD) is the leading cause of nonatherothrombotic myocardial infarction in women under age 40 years, the etiology of ST-elevation myocardial infarction in 1 of 5 women under age 50 years, and a frequent cause of heart attack among pregnant women. Most patients with SCAD do not have traditional risk factors such as tobacco use, high cholesterol, diabetes, but rather, they have abnormalities in the peripheral arteries such as fibromuscular dysplasia, aneurysms, and dissections. The proposed aims of this proposal explore the vascular, autonomic, and myocardial phenotypes in women with SCAD and in doing so better understand pathophysiologic mechanisms, risk for disease, and ultimately guide approaches to improve outcomes.

PI_NAMEs: TWEET, MARYSIA S (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acceleration;acute coronary syndrome;Adverse event;Advisory Committees;Affect;Age;Aging;Aneurysm;Aorta;Aptitude;arterial tortuosity;Arteries;Baroreflex;Biological Markers;Biometry;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Caring;Chest Pain;Cholesterol;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Research;Collagen;Computerized Medical Record;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;Coronary Vessel Anomalies;Data;Data Analyses;Deposition;Diabetes Mellitus;Diagnosis;Disease;disorder risk;Dissection;Dobutamine;Echocardiography;Elastin;Electronics;endothelial dysfunction;Endothelium;Environment;Etiology;Exercise;experience;Female;Fibromuscular Dysplasia;Functional disorder;Future;Goals;Grant;grasp;Hand;healing;health training;hemodynamics;Hemorrhage;Hyperlipidemia;Hypertension;Image;improved;improved outcome;indexing;Individual;insight;Institution;Interdisciplinary Study;interest;International;Isometric Exercise;Knowledge;Lead;Leadership;Link;Manuscripts;Measurement;Mechanics;Medial;Mentors;Mentorship;Mission;Multimodal Imaging;Muscle;Myocardial;Myocardial Infarction;myocardial injury;Myocardial perfusion;National Heart, Lung, and Blood Institute;Nerve;neurovascular;next generation;Outcome Measure;patient population;patient subsets;Patients;Perfusion;Peripheral;Phenotype;Physicians;Physiologic pulse;Physiology;Pregnancy;Pregnant Women;Preparation;Process;prospective;Prospective Studies;Psyche structure;Recording of previous events;Recurrence;Registries;Regulation;reproductive;Research;Research Design;research study;Research Technics;response;Rest;Risk Factors;Science;Scientist;Severities;shear stress;skills;Standardization;Strategic vision;Stress;Stress Tests;stressor;Structure;Surveys;Testing;Thick;Tobacco use;Training;United States National Institutes of Health;Valsalva Maneuver;vascular abnormality;Woman;Women's Health;women's outcomes;Women's study;Work;Writing

PROJECT_TITLE: The Vascular, Autonomic, and Myocardial Phenotypes in Women with Myocardial Infarction due to Spontaneous Coronary Artery Dissection

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: KANSAS CITY

ORG_NAME: KANSAS CITY VA MEDICAL CENTER

PHR: Among military veterans, substance abuse is a strong predictor of both subsequent healthcare utilization and mortality. For veterans who abuse heroin or other opioids, mental health conditions are highly prevalent. These include disorders of mood and anxiety. Although opioid abuse is an important health problem for both veterans and the general population, only limited medications are currently available for treating patients who are addicted to opioids. Melatonin is a hormone and neurotransmitter which plays a role in establishing daily and seasonal rhythms and may also contribute to perception of pain and drug addiction. This project will use an animal model of opioid addiction to determine how melatonin influences the brain mechanisms underlying perception of pain and addiction.

PI_NAMEs: GRASING, KENNETH W. (contact)

PROJECT_TERMS: addiction;Agonist;Animal Model;Animals;antagonist;anti-depressive agents;antidepressant effect;Antioxidants;Anxiety;Attenuated;awake;Behavior;Bolus Infusion;Brain;brain tissue;Circadian Dysregulation;Clinical;Cocaine;cocaine self-administration;conditioned place preference;craving;Cues;Darkness;Dependence;Disease;Dose;Drug Addiction;Drug Kinetics;Economics;Evaluation;Extinction;Food;General Population;Health;health care service utilization;Heroin Abuse;Home;Hormones;Hour;Human;Immobilization;improved;Inflammation;Inflammation Mediators;Injections;innovation;Intake;Interruption;Light;Marketing;Measures;Medical;Melatonin;Melatonin Receptors;Mental Depression;Mental Health;Methods;military veteran;Modeling;Mood Disorders;Morphine;morphine administration;mortality;motivated behavior;Naloxone;Neurotransmitters;novel;open label;Opiate Addiction;opiate tolerance;Opioid;opioid abuse;opioid use;opioid use disorder;opioid withdrawal;Oral;Outcome;overdose death;Oxidative Stress;Pain management;pain perception;pain relief;Patients;Periodicity;Pharmaceutical Preparations;Pharmacotherapy;Pineal gland;Plasma;Prevalence;prevent;Property;Rattus;receptor;reinforced behavior;relapse prevention;Reporting;Rewards;Role;Safety;Seasons;Self Administration;Serotonin;Serotonin Receptor 5-HT2C;Severities;Sleep;Sleep disturbances;Sleep Wake Cycle;social;Substance abuse problem;Swimming;Translating;Veterans;Veterans Health Administration;Wistar Rats;Withdrawal

PROJECT_TITLE: Translating Melatonin- and Serotonin-2C Interactions into Improved Treatments for Pain and Opioid-Use Disorders


ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: This innovative project will study epigenomic modifications in cancer cells and their link to stemness and drug resistance. We hypothesize that treatment with platinum induces chromatin modifications promoting a cancer stem-like phenotype and vulnerability to epigenome modifiers. We propose to tackle this question by using next generation sequencing adapted to the study of rare cell populations, by focusing on the enzyme Dot1L and the target gene, FoxK2. Successful demonstration of this concept will provide the rationale for pursuing Dot1L inhibitors to restore response to platinum in ovarian cancer. We envision that this strategy will increase sensitivity to platinum and impact clinical outcomes. Our findings could be translated to other treatment- resistant solid tumors. As platinum-resistant cancer kills a significant number of US Veterans and military personnel, this project is highly relevant to the Department of Veterans Affairs.

PI_NAMEs: MATEI, DANIELA E (contact)

PROJECT_TERMS: Address;Affect;Aftercare;Area;ATAC-seq;bench to bedside;beta catenin;Biological;Biological Assay;cancer cell;Cancer Model;cancer stem cell;Carboplatin;Cell Line;Cells;Characteristics;Chemoresistance;chemotherapy;ChIP-seq;Chromatin;chromatin modification;Clinic;Clinical;clinical application;Data;Development;DNA;DNA Methylation;Drug resistance;Enzymes;Epigenetic Process;epigenetic therapy;epigenome;epigenomics;experimental study;Genes;Genetic;Genetic Transcription;genome-wide;Heterochromatin;High-Throughput Nucleotide Sequencing;Histones;Human;IL6 gene;Immunodeficient Mouse;In Vitro;in vivo;inhibitor;innovation;interest;Intervention;knock-down;Knock-in;Knock-out;Knowledge;Link;Lysine;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measures;Methylation;Military Personnel;Modeling;Modification;nanoscale;next generation sequencing;Outcome;Ovarian;ovarian neoplasm;Paper;patient derived xenograft model;Patients;pharmacologic;Phenotype;Platinum;Population;pressure;Probability;promoter;Promoter Regions;Proteomics;Publishing;Radiation therapy;Recurrent tumor;refractory cancer;repaired;Residual Neoplasm;Residual state;Resistance;Resistance development;response;self-renewal;Signal Transduction;Solid Neoplasm;Specimen;Spectrum Analysis;stem;stem cell biology;stem cell survival;stemness;Stress;Structure;targeted agent;Technology;Testing;theories;Therapeutic;transcription factor;Transcriptional Regulation;Transferase;Transforming Growth Factor beta;Translating;Translations;Transposase;tumor;tumor initiation;tumor microenvironment;United States Department of Veterans Affairs;Veterans;Visualization;women's diagnosis;Work;Xenograft procedure

PROJECT_TITLE: New Epigenetic Targets in Ovarian Cancer Stem Cells


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Spinal cord injury (SCI) is among the most disabling conditions affecting wounded members of the US military. No effective treatment has been available for SCI veterans. Our goal is to understand how lumbar motoneurons (MNs) are altered caudal to a thoracic SCI and how a beneficial restorative treatment affects their Using an adult mouse T9 moderate contusive SCI model and an adeno-associated virus serotype 2 vector encoding NT-3 (AAV2-NT-3) gene transfer approach, we will determine the mechanism by which NT-3 improves recovery after SCI and long-term efficacy of the NT-3 treatment using a clinically feasible delivery route, and whether exercise training will enhance the effects of NT- 3, and how the functional role of specific descending pathways will affect lumbar MN neural circuitry and functional recoveries after an optimal treatment. This proposal will reveal the fundamental mechanism of NT- 3/exercise training on MN circuitry remodeling and also facilitate the development of new therapeutics for SCI. reorganization and functional consequences.

PI_NAMEs: WALKER, CHANDLER  (contact)

PROJECT_TERMS: Adult;Affect;Anatomy;Atrophic;Axon;axon growth;Behavior;Behavioral;Cervical;Chest;Chronic;Clinical;combinatorial;Dependovirus;Development;Disabling condition;effective therapy;Effectiveness;efficacy evaluation;Electrophysiology (science);Exercise;exercise training;experimental study;Gene Expression Profile;gene therapy;Gene Transfer;Goals;Growth;Hindlimb;Human;Impairment;improved;injured;Injury;Locomotor Recovery;Mediating;Medical;member;Military Personnel;Modeling;Morphology;Motor;motor impairment;Motor Neurons;Motor output;Motor Pathways;Mus;Muscle;Muscular Atrophy;Natural regeneration;Nature;neural circuit;Neurites;neuronal circuitry;Neuronal Plasticity;neuronal survival;neurotransmission;neurotrophic factor;Neurotrophin 3;novel;novel therapeutic intervention;novel therapeutics;optimal treatments;Paralysed;Pathologic;Pathway interactions;Phase;Physiological;Play;Protein Family;Quality of life;Recovery;Recovery of Function;repair strategy;Research;restoration;restorative treatment;retrograde transport;Role;Route;Satellite Viruses;sciatic nerve;Serotyping;signature molecule;Site;Spinal;Spinal cord injury;Spinal cord injury patients;spinal pathway;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Techniques;Therapeutic;Thoracic spinal cord structure;Training;Training Programs;Translating;Trauma;treatment comparison;United States;vector;Veterans;Viral

PROJECT_TITLE: Exercise and NT-3-mediated lumbar motoneuron plasticity and recovery after SCI

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Society for Inherited Metabolic Disorders (SIMD) meeting will help to train young individuals to become investigators to enhance the research endeavors and to train new physicians to take care of patients with disorders of the body’s biochemistry. There are very few such specialists in the country and providing travel funds for new trainees to meet and present their research encourages them to remain in the field.

PI_NAMEs: BERRY, GERARD THOMAS (contact)

PROJECT_TERMS: Affect;American;Area;Arthritis;Award;Biochemistry;Blindness;Cerebral Palsy;Cities;Clinical;Clinical Trials;Congresses;cost;Country;design;Development;Diabetes Mellitus;Disease;effective therapy;efficacy evaluation;Enzymes;exome;Failure;Funding;Genes;Genetic;genome sequencing;Goals;Grant;Growth;Heart Diseases;Hepatic;Inborn Errors of Metabolism;Individual;Inherited;Intellectual functioning disability;International;Japan;kidney dysfunction;Knowledge;Mass Spectrum Analysis;Medical Genetics;medical schools;meetings;Metabolic;Metabolic Diseases;Minority;Molecular;Neonatal Screening;Neuromuscular Diseases;novel therapeutics;Pathway interactions;Patient Care;Pharmaceutical Preparations;Physicians;Privatization;Recruitment Activity;Research;Research Personnel;Scholarship;screening program;Societies;Sodium Chloride;Source;Specialist;Training;Travel;United States National Institutes of Health;Variant;whole genome;Woman

PROJECT_TITLE: Society for Inherited Metabolic Disorders Annual Meeting

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Emergency Care

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE U.S. Emergency Departments (ED) had approximately 145 million visits in 2016, a figure that has been steadily rising for the past twenty years.1,2,3 Twenty-five percent of the U.S. population visit the ED each year4, many of whom are the sickest and most vulnerable in the health care system,11 presenting with complex disease processes and high risks of adverse events. There is a specific need for emergency care clinicians and related health professionals to be trained as clinical and health services researchers to improve health outcomes and decrease preventable ED visits.

PI_NAMEs: RICHARDSON, LYNNE D. (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Mount Sinai Clinician Scientist Training Program in Emergency Care Research


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE: Motor deficits, such disturbances in voluntary fine motor skills, are associated with healthy aging as well as the pathological aging observed in Alzheimer’s disease (AD). Despite overlapping phenotypes, age-related motor deficits in physiological (i.e., healthy) and pathological (e.g., AD) have traditionally been studied separately – thus, it is unknown if motor phenotypes and the underlying mechanisms present in healthy aging are distinct from those that precede AD cognitive symptoms. Through a combination of behavioral, molecular, and cellular reprogramming techniques, this project will specifically investigate the role of corticospinal neurons (the primary drivers of voluntary fine motor control and the only direct output from the cortex to the spinal cord) in fine motor decline of healthy aging and AD.

PI_NAMEs: WINTER, CARLA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Ablation;Address;Adult;Age;age related;age related changes;aged;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;American;Anatomy;Area;Axon;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;Blindness;Cell Nucleus;Cell Reprogramming;cell type;Cells;Cervical;Clinical Skills;Cognitive deficits;Communication;Communities;Data;Dissection;Educational process of instructing;Elderly;Foundations;Functional disorder;Future;Genes;healthy aging;Heterogeneity;Human;Impairment;In Situ Hybridization;Injections;insight;Investigation;Joints;Label;Light;Link;Literature;Machine Learning;medical schools;Mentorship;Methods;Molecular;Morbidity - disease rate;mortality;Motor;motor control;Motor Cortex;motor deficit;motor impairment;Motor Skills;motor symptom;mouse model;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurologic;neuronal cell body;Neurons;neuropathology;Neurosciences;normal aging;Output;Pathologic;pathological aging;Pathway interactions;Patients;Performance;Phenotype;Physiological;prevent;Publishing;Quality of life;Rattus;Rejuvenation;Reporting;Resolution;Retinal Ganglion Cells;Role;single nucleus RNA-sequencing;Spinal Cord;Structure;Symptoms;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Training;transcriptomics;Translating;Viral Vector

PROJECT_TITLE: Behavioral, molecular, and functional dissection of corticospinal neurons in motor performance deficits of physiological and pathological aging


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will develop artificial intelligence (AI) tools to be applied to computed tomography (CT) images of the body. The goal is to improve the efficiency and diagnostic performance of radiologists, who analyze these complex CT scans to look for a wide variety of diseases in many different organs of the body.

PI_NAMEs: LO, JOSEPH Y (contact);RUBIN, GEOFFREY D

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Abdomen;abdominal CT;Active Learning;Address;Algorithms;Anatomy;Archives;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Attention;Automated Annotation;Body System;Case Study;Chest;chest computed tomography;Classification;Clinical;Clinical Decision Support Systems;Complex;Computer Assisted;Computer-Assisted Diagnosis;cone-beam computed tomography;Consumption;cost;Data;Data Set;Databases;deep learning;deep learning model;Detection;Development;Diagnostic;Disease;Expert Systems;Face;federated learning;Foundations;Future;Goals;Health system;Heterogeneity;Image;imaging modality;improved;innovation;Institution;Label;large datasets;learning strategy;Lung;Manuals;Medical Imaging;Modeling;Natural Language Processing;Nodule;Organ;Outcome;Patients;Pelvis;Performance;radiologist;Radiology Specialty;Reporting;Research Personnel;Resolution;Scanning;Shapes;Site;Structure;Supervision;System;Testing;Therapeutic Equivalency;Time;tool;Training;Triage;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Computer-Aided Triage of Body CT Scans with Deep Learning

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Organ Transplantation;Transplantation

PHR: Lung transplantation is an effective short-term treatment for patients with end-stage pulmonary disease, but long- term outcomes are disappointing. Chronic lung allograft dysfunction (CLAD) is the most important immune- mediated complication after lung transplantation, representing the leading cause of late death in lung transplant recipients. This proposal will integrate two large existing NIH-funded lung transplant datasets and apply innovative statistical methods to define CLAD progression patterns and inform the design of future CLAD treatment studies.

PI_NAMEs: TODD, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Address;Adult;American;arm;Bayesian Method;Behavior;Cessation of life;Characteristics;Chronic;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Communities;Complement;Complication;Cox Proportional Hazards Models;Data;data integration;Data Set;design;Diagnosis;Disease;Disease Progression;Eligibility Determination;Enrollment;Ethics;Event;Exhibits;follow-up;Functional disorder;Funding;Future;Goals;graft dysfunction;Heterogeneity;high risk;Immune;Immune response;improved;Industry;information gathering;innovation;interest;Intervention;Intervention Trial;Investigation;Literature;longitudinal analysis;Lung;lung allograft;Lung Diseases;Lung Transplantation;Measures;Mediating;Methods;Modeling;Modernization;mortality risk;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Natural History;Organ Transplantation;Outcome;Participant;Patient Selection;Patients;Pattern;Phenotype;placebo controlled study;Population;pre-clinical;Progressive Disease;Publishing;pulmonary function;pulmonary function decline;Pulmonary function tests;Randomized;Rare Diseases;rational design;Research;response;Risk Factors;Sample Size;secondary analysis;simulation;Source;standard of care;Statistical Methods;Statistical Models;statistics;success;Surrogate Endpoint;Time;transplant centers;Transplant Recipients;Transplantation;Transplanted Lung Complication;treatment effect;treatment trial;trial design;United States National Institutes of Health;Work

PROJECT_TITLE: Secondary Analyses to Support the Rational Design of Clinical Trials in Chronic Lung Allograft Dysfunction

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


FUNDING_MECHANISM: OTHERS

ORG_CITY: LEXINGTON

ORG_NAME: VA MEDICAL CENTER - LEXINGTON, KY

ORG_STATE: KY

PHR: Parkinson’s disease is the most common neurodegenerative movement disorder of the elderly, affecting over four million people worldwide, and is responsible for significant health care dollar expenditures annually. This disease afflicts a disproportionately large number of US Veterans based on factors such as advancing age, male gender, and exposure to certain toxins, all of which are associated with increased risk for the disease. Progress toward effective treatment has been hindered by the lack of a biomarker that can diagnose and distinguish Parkinson’s disease from related neurodegenerative conditions. The proposed research will detect pathogenic forms of the protein alpha-synuclein in the blood of patients with Parkinson’s and related diseases, with the ultimate goal of expanding diagnostic, prognostic, and therapeutic options for affected US Veterans.

PI_NAMEs: YAMASAKI, TRITIA  (contact)

PROJECT_TERMS: Acceleration;accurate diagnosis;Affect;Aging;alpha synuclein;amplification detection;Antibodies;Area;Award;Basic Science;Binding;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biosensor;Blood;Blood Platelets;Blood specimen;Braak's hypothesis;Brain;C-terminal;career;Cell-Free System;Cells;Central Nervous System;cerebral atrophy;Characteristics;Clinic;Clinical;Clinical Research;collaborative environment;Consent;Deep Brain Stimulation;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Progression;disorder risk;DNA Sequence Alteration;Documentation;Early Diagnosis;effective therapy;Elderly;Engineering;Epitopes;Erythrocytes;Evaluation;exosome;Expenditure;experience;Exposure to;Faculty;FDA approved;Fluorescence Resonance Energy Transfer;Gender;Genetic;genetic manipulation;Goals;Healthcare;Image;imaging modality;Imaging Techniques;In Vitro;insight;Kentucky;Knowledge;Ligands;liquid biopsy;Liquid substance;male;Mentors;Methods;Modality;Molecular;Molecular Conformation;Motor;Movement;Movement Disorders;Multiple System Atrophy;Nerve Degeneration;Neurodegenerative Disorders;Neurology;novel;novel marker;Parkinson Disease;Pathogenicity;Pathologic;Pathology;patient population;Patients;Peripheral;Persons;Plasma;Population;Positioning Attribute;prion-like;Process;professor;Prognosis;prognostic;Property;protein aggregation;Proteins;Publishing;rare condition;Records;Research;Sampling;sensor;Solubility;Structure;success;synuclein;synucleinopathy;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Toxin;Training;Training Programs;translational scientist;transmission process;Universities;Veterans;Whole Blood;Work

PROJECT_TITLE: Enhancing diagnosis of Parkinson's disease and multiple system atrophy via detection of alpha-synuclein seeding activity


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative This project delineates essential and fundamental molecular pathways that are conserved throughout eukaryotes, including humans. Understanding these pathways and how they are integrated with other cellular pathways will provide the intellectual underpinning for investigators carrying out translational research. Defects in these pathways of ribosome assembly lead to human diseases, including Acute T-cell lymphoblastic leukemia and Shwachman-Diamond syndrome.

PI_NAMEs: JOHNSON, ARLEN W (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acute T Cell Leukemia;Address;Cells;Complex;Defect;Disease;Ensure;Eukaryota;Eukaryotic Cell;Event;genetic information;Genetic Transcription;Genus Mentha;Human;human disease;interest;Lead;Licensing;Life;Ligands;Messenger RNA;Molecular;Molecular Machines;particle;Pathway interactions;Planet Earth;Process;Production;Proteins;Quality Control;Research Personnel;Ribosomal Biogenesis Pathway;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Helicase;Role;scaffold;Shwachman-Diamond syndrome;Structure;Translational Research;Translations;U3 small nucleolar RNA

PROJECT_TITLE: Eukaryotic Ribosome Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative  Image-guided delineation of interferon-γ via positron emission tomography (PET) to assess outcomes of cancer immunotherapy has been successfully established. In this proposal, its potential to be a predictive imaging biomarker will be evaluated. Preparation of the radiotracer toward clinical translation to improve clinical decision-making is also proposed.

PI_NAMEs: GIBSON, HEATHER MARIE;VIOLA, NERISSA THERESE (contact)

PROJECT_TERMS: Address;Adjuvant Chemotherapy;analog;Antibodies;antibody-dependent cell cytotoxicity;Autoimmune Diseases;Binding;biomarker discovery;Breast Cancer Model;Breast Cancer Patient;cancer immunotherapy;cancer type;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Chronic;Clinical;clinical decision-making;clinical translation;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Detection;Development;DNA;Dose;dosimetry;Drug Kinetics;Drug or chemical Tissue Distribution;effector T cell;Environment;Equilibrium;ERBB2 gene;Evaluation;Event;exhaustion;Exhibits;Formulation;Genetic;genetic linkage analysis;Genomics;Homologous Gene;Human;Image;image guided;imaging biomarker;Immune;immune activation;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunity;Immunologic Monitoring;ImmunoPET;immunoregulation;Immunosuppressive Agents;Immunotherapy;improved;In Situ;In Vitro;Inbred Mouse;Inflammatory;Interferon Type II;Intervention;Investigational New Drug Application;Malignant Neoplasms;Maps;Measures;Mediating;Memory;Methods;Modality;Modeling;Monitor;Monoclonal Antibodies;mouse model;Mus;Neoadjuvant Therapy;novel;Oncology;Outcome;Outcome Assessment;overexpression;Passive Immunotherapy;Patients;PD-1/PD-L1;PD-L1 blockade;Peripheral;Persuasive Communication;Population;Positron-Emission Tomography;pre-clinical;Prediction of Response to Therapy;predictive marker;Predictive Value of Tests;Preparation;Process;Production;programmed cell death ligand 1;programmed cell death protein 1;Quantitative Trait Loci;Radioactive;radiotracer;Rationalization;Rattus;Recombinants;response;restraint;Retrospective Studies;Rodent;Role;Single Nucleotide Polymorphism Map;SNP array;Specificity;T cell anergy;T cell infiltration;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;tool;Toxicology;Tracer;Translations;Trastuzumab;Treatment outcome;treatment strategy;tumor;tumor eradication;tumor heterogeneity;Tumor Immunity;tumor microenvironment;Up-Regulation;Vaccination;Variant;Visualization;Xenograft procedure

PROJECT_TITLE: Delineating Functional Immunity via Image-Guided PET


PHR: The proposal addresses basic health issues since kidney disease causes untold suffering and kills more Veterans than many cancers. Ischemic injury to the kidney results in acute kidney injury, progression of chronic renal disease to end stage kidney disease and transplant failure; yet there is currently no specific treatment. This proposal aims to define mechanisms of protection and potential treatments with the ultimate goal of effective therapies to improve the lives of Veterans and other patients.

PI_NAMEs: KELLY, KATHERINE J (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Anti-Inflammatory Agents;Antioxidants;Bilateral;Biological;biological adaptation to stress;Blood Platelets;Blood Vessels;Caring;catalase;Cell Therapy;Cell Transplantation;Cells;Cessation of life;Chronic Kidney Failure;Clinical Data;Creatinine;cytokine;Data;Death Rate;Depressed mood;Development;Disease;Distant;effective therapy;Effectiveness;End stage renal failure;epidemiologic data;Epithelial Cells;Etiology;evidence base;exosome;extracellular vesicles;Failure;Functional disorder;Funding;Future;Goals;Health;Heart;heart function;Hospitalization;Hour;immune cell infiltrate;improved;improved outcome;Inflammation;Inflammatory;Injury;Injury to Kidney;Intensive Care;Ischemia;ischemic injury;Ischemic Preconditioning;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Knowledge;Liver;Lung;Malignant Neoplasms;Mediator;Medical;meetings;Methods;Modeling;mortality;Organ;Organ Transplantation;Outcome;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;pre-clinical;preservation;Rattus;Recovery;Renal function;renal ischemia;Role;Skin;Source;Structure;Superoxides;Techniques;Therapeutic;transcriptomics;Translations;Tubular formation;Veterans;Work

PROJECT_TITLE: Protecting the kidney and remote organs following renal ischemia


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Nutrition;Prevention;Social Determinants of Health;Urologic Diseases

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This renewal application will support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 male health professionals ongoing since 1986. The cohort includes biennial questionnaires, cancer outcomes, and mortality information linked with biospecimens: plasma, red cells, germline DNA, toenail samples, and tumor tissue. With additional follow-up, particularly after cancer diagnosis, the cohort remains ideally positioned to make innovative contributions to the overall goal of reducing the burden of cancer and identifying primary and secondary prevention strategies.

PI_NAMEs: MUCCI, LORELEI ;WILLETT, WALTER C. (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Address;African American;Age;Alternative Therapies;Archives;Artificial Intelligence;artificial intelligence method;biobank;Biological;Biological Markers;built environment;Calibration;Cancer Burden;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;Cessation of life;cohort;Cohort Analysis;Cohort Studies;Collaborations;Colon Carcinoma;Communities;Computer software;COVID-19 pandemic;Data;data dictionary;Data Files;data management;Data Management Resources;data sharing;Databases;Death Rate;Diagnosis;Diet;dietary;Dietary Assessment;Dietary Questionnaires;Disease Progression;DNA;Elements;Environment;Environmental Exposure;epidemiology study;Erythrocytes;Feces;follow-up;Follow-Up Studies;Food;Frequencies;Funding;genetic epidemiology;Germ Lines;Goals;Grant;Health;Health Professional;Health Resources;Hematologic Neoplasms;Hematoxylin and Eosin Staining Method;human old age (65+);Incidence;indexing;Infrastructure;innovation;Laboratories;lifestyle factors;Link;male health;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;marijuana use;Measures;member;men;Mental Health;Methods;middle age;Modeling;modifiable risk;Molecular Epidemiology;Morbidity - disease rate;Morphology;mortality;Neighborhoods;Newly Diagnosed;non-smoker;novel;Nucleic Acids;Nurses' Health Study;Nutrient;Outcome;pandemic disease;Paper;Participant;Pharmaceutical Preparations;Physical activity;physical conditioning;Plasma;Positioning Attribute;Prevention strategy;Primary Prevention;Productivity;Prostatic Neoplasms;Publications;Publishing;Quality of life;Questionnaires;Renal Carcinoma;Research;Research Personnel;Resource Sharing;Resources;response;Risk;Risk Factors;Running;Sampling;Secondary Prevention;Secure;Sex Differences;Slide;Smoking;Socioeconomic Status;Specimen;Structure of nail of toe;Support System;Systems Analysis;Time;Tissue Banks;Tissue Microarray;Tissues;Tumor Tissue;Update;user-friendly;virtual;Weight

PROJECT_TITLE: Cancer Epidemiology Cohort in Male Health Professionals


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: The goal of this longitudinal study is to use a life course approach to examine the relationship between patient residential histories at midlife and prostate cancer disparities. Data from the PA Cancer Registry will be linked to hospital billing data and LexisNexis address data to address the study aims.

PI_NAMEs: ZEIGLER-JOHNSON, CHARNITA M. (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Adult;Affect;Age;aging related disease;anti-cancer research;billing data;black men;Black race;Cancer Biology;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;cancer survival;Caring;Censuses;Characteristics;Chronic stress;Cities;Clinic;Communities;Community Healthcare;community intervention;community planning;Complex;Continuity of Patient Care;Cost Control;critical period;Data;data registry;Death Rate;Diagnosis;Disadvantaged;Disease;disease disparity;Disease Outcome;Disparity;effective intervention;Environment;environment related cancer;Ethnic Population;experience;Exposure to;future implementation;Goals;Health;Health Care Costs;high risk;Hospitals;improved;Incidence;Income;Individual;Inequity;Inflammation;innovation;Intervention;Investigation;Learning;Life;Life Cycle Stages;Link;Longevity;Longitudinal Studies;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medicare;men;middle age;Modeling;Modification;mortality;Movement;Needs Assessment;Neighborhoods;neoplasm registry;novel;novel strategies;older patient;Outcome;outreach;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pennsylvania;Persons;Philadelphia;Physiological;Policies;Population;Poverty;Prostate;prostate cancer model;prostate cancer risk;Race;racial disparity;racial population;Recording of previous events;Records;Research;Resources;Risk;Risk Factors;Role;socioeconomics;Strategic Planning;Structural Racism;Suggestion;survival disparity;Survival Rate;Survivors;survivorship;Time;Tissues;trend;Tumor Biology;tumor progression;Vulnerable Populations;Work

PROJECT_TITLE: Examining the Relationship between Residential History at Midlife and Prostate Cancer Outcomes


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project narrative: We have identified novel roles of eukaryotic-line serine/threonine kinase (eSTK) signaling pathway that controls β-lactam resistance in Staphylococcus aureus through classical and non-classical mediators. β-lactams are important drugs for treating S. aureus infections, but resistance to these drugs often complicates treatment. In this proposal, we seek to identify the mechanistic basis of these novel modes of β-lactam resistance.

PI_NAMEs: CHATTERJEE, SOM  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affinity;Amino Acids;Antibiotic Resistance;Antibiotics;Attenuated;Bacteria;Bacterial Genes;bacterial resistance;beta-Lactam Resistance;beta-Lactams;Binding;Biochemical;Cell division;Cell Physiology;Cell Wall;Communities;Cytosol;Data;derepression;Drug resistance;drug sensitivity;Ensure;Expenditure;FLT3 gene;Genes;genetic approach;genetic regulatory protein;genome sequencing;Goals;Hospitals;improved;inducible gene expression;Infection;inhibitor;Integral Membrane Protein;kinase inhibitor;Knowledge;loss of function;Mediating;Mediator;Membrane;Metalloproteases;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Molecular Genetics;mutant;Mutation;novel;novel therapeutic intervention;overexpression;Pathway interactions;Penicillin-Binding Proteins;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Predisposition;Protein Dephosphorylation;Protein-Serine-Threonine Kinases;Proteins;Proteolysis;Proteomics;Quality Control;Regulation;Regulatory Pathway;Repression;Resistance;resistant strain;Resources;Role;sensor;Serine;Serine/Threonine Phosphorylation;Signal Pathway;Signal Transduction;Site;Staphylococcus aureus;Staphylococcus aureus infection;System;Therapeutic;Threonine;Transcription Repressor;Transcriptional Activation;Treatment Efficacy;Zinc

PROJECT_TITLE: Serine/threonine kinase signaling in beta-lactam resistance of Staphylococcus aureus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Antibiotic-resistant infections are rapidly spreading and taking a staggering toll in all healthcare systems including the VA Healthcare system. Of critical importance, there are few approved antibacterial drugs currently available to treat many Gram-negative bacterial infections and few new drugs in the pipeline. The most difficult to treat pathogens are the Gram-negative bacteria that are resistant to all antibiotics (so called “Superbugs” containing NDM and KPC enzymes). Most worrisome is their resistant to Imipenem, the “last line” agent that is used in the most serious cases. We have also found that some Superbugs are also resistant to the recently developed drugs just released (e.g., Avibactam). Even new drugs being developed are at risk. We are taking new approaches based on basic research to understand why resistance to Imipenem and Avibactam occurs in KPC and how resistance to cephalosporins can further emerge in NDMs. We have been extremely fortunate to have built a program that has been at the forefront of new drug resistance research in the VA for nearly 20 years.

PI_NAMEs: BONOMO, ROBERT A. (contact)

PROJECT_TERMS: Active Sites;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Ampicillin Resistance;Anti-Bacterial Agents;antibiotic resistant infections;Antibiotics;antimicrobial;Award;bacterial resistance;Basic Science;beta-Lactamase;beta-Lactams;Binding;Biochemical;carbapenem resistance;carbapenemase;Carbapenems;Catalysis;Cefepime;Ceftazidime;Cephalosporin Resistance;Cephalosporins;chemotherapy;Clinical;Complex;Computer Analysis;design;Drug resistance;Electrons;Enzymes;Escherichia coli;Evolution;Extended-spectrum β-lactamase;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Grant;Healthcare Systems;Hydrolysis;Hydrophobicity;Imipenem;inhibitor;insight;interdisciplinary approach;Investigation;Kinetics;Klebsiella pneumoniae;Learning;Methods;Molecular Conformation;molecular dynamics;Movement;Multienzyme Complexes;Mutagenesis;Mutation;Nature;Nitrogen;novel;novel strategies;novel therapeutics;Pain;pathogen;Patients;Pharmaceutical Preparations;Phenotype;Piperacillin;Positioning Attribute;programs;Proteins;Research;Resistance;Risk;Role;Serine;Signal Transduction;Structure;Structure-Activity Relationship;Substrate Specificity;Sulfate;Superbug;Tazobactam;Time;Variant;X-Ray Crystallography

PROJECT_TITLE: The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1

STUDY_SECTION: INFB

STUDY_SECTION_NAME: Infectious Diseases B[INFB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Parasite resistance to artemisinin with a validated mutation in the pfkelch13 (k13) gene has been found in Rwanda. Given that all front line antimalarial combination therapies for treating Plasmodium falciparum in Africa rely on artemisinin, this portends serious setbacks for the large-scale efforts aiming to control and eliminate this disease. We will use large-scale genomics, experimental systems, and mathematical modeling to map and study the spread of resistance overtime, and, together, these studies will improve our understanding of the biology and evolution of this resistance in Africa, help us to predict its spread and allow development of interventions.

PI_NAMEs: BAILEY, JEFFREY A. (contact);JULIANO, JONATHAN J;MAZARATI, JEAN BAPTISTE

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;Anti-malarial drug resistance;Anti-malarials;Area;Artemisinins;Asia;Biological Assay;Biology;Blood;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Combined Modality Therapy;Communities;Country;Coupled;Culicidae;Data;Data Set;design;Disasters;Disease;Drug resistance;Effectiveness;efficacy study;Evolution;Failure;Falciparum Malaria;Feeds;fitness;Founder Effect;Frequencies;Future;Genes;Genetic;Genome;genome wide association study;Genomics;Genotype;Goals;Haplotypes;High Prevalence;High-Throughput Nucleotide Sequencing;Human;human migration;improved;In Vitro;in vivo;Infection;innovation;Knowledge;Location;longitudinal analysis;Malaria;malaria infection;Maps;mathematical model;Measures;migration;Modeling;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;next generation;novel;Parasite resistance;Parasites;Patients;Persons;Pharmaceutical Preparations;Plasmodium falciparum;Population;predictive modeling;prospective;Public Health;Reporting;Resistance;resistance gene;resistance mutation;Resolution;Resources;Risk Factors;Route;Rwanda;sample collection;Sampling;Site;Southeastern Asia;Statistical Methods;Statistical Models;Structure;System;Tanzania;targeted sequencing;Testing;therapy development;Time;transmission process;Travel;Treatment Efficacy;World Health Organization

PROJECT_TITLE: Artemisinin Resistance in Africa: its emergence and evolution in Rwanda

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Sophisticated synthetic gene circuits have been designed and constructed for clinical applications, such as treating infectious diseases and cancer. However, the substantial heterogeneity resulting from the interactions between the gene circuit and host cells significantly affects the functional robustness of engineered gene circuits. Our proposed studies aim to quantify, characterize, and control heterogeneity in the host-aware synthetic gene circuits and make the circuits operate as desired in a complicated real-world environment.

PI_NAMEs: TIAN, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Affect;Algorithms;Awareness;bacterial community;Bacterial Infections;Biochemical Reaction;Biology;Cell division;Cells;Chemicals;clinical application;Communicable Diseases;Communication;Complex;design and construction;Development;Engineered Gene;Engineering;Environment;Feedback;Fluorescence;Gene Expression;Genes;Growth;Heterogeneity;Hybrids;In Situ;Laboratories;Malignant Neoplasms;Measurement;Mechanics;Microfluidics;Modeling;Nature;neglect;Noise;Organism;Predisposition;Publishing;Pythons;rational design;Research;Resources;simulation;Source;Synthetic Genes;System;tumor microenvironment;web interface;Work

PROJECT_TITLE: Multi-Scale Engineering of Heterogeneity in the Host-Aware Synthetic Gene Circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Rare Diseases;Sarcoidosis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative It is clear that new approaches for the detection of the etiologic antigen(s) in sarcoidosis are needed. Using bronchoalveolar lavage cells from sarcoidosis patients from the United States, this proposal will extend our current level of understanding of the role of CD4+ T cells in the initiation and progression of sarcoidosis. The identification of sarcoidosis antigens could lead to earlier diagnosis and more directed therapeutic intervention that would directly impact the health of affected individuals.

PI_NAMEs: PALMER, BRENT E (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Affect;African American population;Alleles;Antigens;Aspergillus nidulans;Biological Assay;Biological Markers;Biometry;Bronchoalveolar Lavage;caucasian American;CD4 Positive T Lymphocytes;Cell Separation;Cells;Chronic berylliosis;Clone Cells;cohort;combinatorial;Complex;Data;Detection;Diagnosis;Disease;Early Diagnosis;enzyme linked immunospot assay;Epitopes;Etiology;Frequencies;Funding;Genes;Granulomatous disease;granulomatous lung disease;Health;Histocompatibility Antigens Class II;HLA-DR3 Antigen;HLA-DRB1;Human;Hybridomas;Individual;innovation;Interdisciplinary Study;interest;Interferon Type II;Interleukin-2;Knowledge;Libraries;Link;Lofgren Syndrome;Lung;Molds;Mus;novel;novel strategies;Onset of illness;Pathogenesis;Patients;Peptides;Population;Prognosis;Protein Databases;Proteins;Pulmonary Sarcoidosis;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Sarcoidosis;Scanning;screening;Severity of illness;Sir2-like Deacetylases;Site;Specificity;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Therapeutic Intervention;United States

PROJECT_TITLE: T cell Epitope Discovery in Sarcoidosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Hematology;Pediatric;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Bleeding disorders in women are an under-recognized and under-treated condition, and von Willebrand Disease (VWD) is the most common bleeding disorder diagnosed in women. This study will develop a screening algorithm for VWD that incorporates a brief bleeding history and point-of-care iron level. We will test the algorithm's validity, acceptability, and feasibility in primary care settings.

PI_NAMEs: OBRIEN, SARAH H (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: 20 year old;Adolescent;Adult;Affect;Algorithms;Assessment tool;Blood Coagulation Disorders;Caregivers;Caring;Child;Childbirth;Clinic;Clinical;Clinical Research;Clinical Trials;Data;Diagnosis;Early Diagnosis;Early identification;Enrollment;Event;experience;Female;Ferritin;Foundations;Frequencies;Future;General Population;girls;Goals;Guidelines;Health;Health Personnel;health related quality of life;Hematology;Hemophilia A;Hemorrhage;Hemostatic function;Hysterectomy;implementation framework;Incidence;innovation;International;Intervention;Interview;Iron;iron deficiency;Iron deficiency anemia;Laboratories;Measurement;Measures;medical specialties;meetings;Menorrhagia;Menstruation;Mission;Morbidity - disease rate;mortality;Operative Surgical Procedures;Outcome;Parents;Participant;patient population;Patients;point of care;Postpartum Period;Primary Care;primary care clinic;primary care setting;prospective;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;recruit;Reference Values;Research;Research Personnel;research study;screening;screening guidelines;Screening procedure;Severities;Societies;Specificity;standard of care;Structure;study population;success;Symptoms;Technology;Testing;Thrombosis;Time;treatment center;United States;Validation;Visit;von Willebrand Disease;Woman;women's diagnosis;Work;young woman

PROJECT_TITLE: Developing Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: The proposed training program is designed to provide both the breadth and depth of didactic and research training necessary to prepare life scientists for this new era of interdisciplinary and collaborative research and discovery.

PI_NAMEs: D'SOUZA, VICTORIA MANUEL (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Cells;Joints;Organism;programs

PROJECT_TITLE: Joint Program in Molecules, Cells, and Organisms

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE This research proposes to develop a clinically practical 2D stationary X-ray source system that will significantly improve image quality in digital breast tomosynthesis while simplifying system design and thereby reducing system costs. The net result would be to greatly increase the capability of digital breast tomosynthesis systems while broadening their availability to bring better care to more people sooner.

PI_NAMEs: SCHWOEBEL, PAUL R (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TITLE: A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative This application is aimed at augmenting Medication for Opioid Use Disorder (MOUD) usual care with a time- limited wraparound intervention called “Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking (MISSION) specifically for individuals with co-occurring opioid addiction and mental illness given that they have high rates of treatment discontinuation and poor outcomes. This is a 4-year, 5-arm RCT with a fractional factorial design among 1,000 patients across 9 MOUD programs to test the added benefit of MISSION or its components + MOUD compared to MOUD alone.

PI_NAMEs: GONZALEZ, GERARDO ;LI, WENJUN ;OLMSTEAD, TODD ALDEN;SMELSON, DAVID A (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: addiction;Affect;arm;Assertiveness;Behavior Therapy;Capital;care systems;Characteristics;Client;Clinic;Clinical;Clinical Practice Guideline;Combination Medication;Combined Modality Therapy;Communities;Community Services;Complex;cost;cost effective;cost estimate;cost-effectiveness evaluation;Criminal Justice;demographics;design;Drug Screening;economic evaluation;Educational Curriculum;effective intervention;Effectiveness;effectiveness evaluation;effectiveness study;empowerment;Evidence based practice;Future;Goals;Group Therapy;Health;Health Services Accessibility;Healthcare;Homelessness;Hybrids;implementation study;improved;improved outcome;Individual;innovation;Intervention;Investments;Massachusetts;Measures;Mediating;Medical;medication for opioid use disorder;Mental disorders;Mental Health;multi-component intervention;National Institute of Mental Health;Opiate Addiction;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Outpatients;outreach;Overdose;Participant;Partnership Practice;Patient Self-Report;Patients;peer support;personalized intervention;personalized medicine;Persons;Population;predictive modeling;profiles in patients;programs;Protocols documentation;Provider;psychosocial;Psychosocial Assessment and Care;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Relapse;Research Personnel;research to practice;response;Service setting;Services;Severities;sobriety;standard of care;Strategic Planning;Structure;substance use;Suicide;Symptoms;System;Systems Integration;Testing;Therapeutic;Therapeutic Effect;Time;treatment as usual;United States;United States Department of Veterans Affairs;uptake

PROJECT_TITLE: Supporting Treatment Access and Recovery for Co-Occurring Opioid Use and Mental Health Disorders (STAR-COD)


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Various mechanisms drive hyperactivity of the WNT signaling pathway in cancer. Defining and understanding these mechanisms will facilitate cancer treatment and improve patient outcome. This training proposal aims to clarify the roles of the WTX tumor suppressor and the druggable CSNK1g kinase isoforms in WNT signaling regulation.

PI_NAMEs: AGAJANIAN, MEGAN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Adult;Amaze;attenuation;beta catenin;Biochemistry;Biological Assay;Biology;Biotinylation;Bone Diseases;Cancer Model;cancer therapy;career;casein kinase I;Cell Fate Control;Cell membrane;Cell Nucleus;Cell Proliferation;Cell surface;Cell Survival;Cells;Cellular biology;Chemicals;Clathrin;Colorectal Cancer;Complex;Consensus;Data;Development;developmental disease;Docking;Down-Regulation;drug discovery;Drug Targeting;Embryonic Development;Endocytosis;Evaluation;Event;Excision;experience;experimental study;extracellular;Family;Feedback;Flow Cytometry;functional genomics;Future;gain of function;Genes;genetic manipulation;Genetic Transcription;Goals;Homeostasis;Human;human disease;Hyperactivity;improved;in silico;Informatics;inhibitor;kinase inhibitor;Ligands;Ligation;Literature;live cell imaging;Longevity;loss of function;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;member;Microscopy;migration;Molecular;Nature;Neoplasm Metastasis;Nervous System Disorder;new therapeutic target;Normal Cell;novel;Pathway interactions;Patient-Focused Outcomes;Pharmacology;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;Postdoctoral Fellow;programs;Proliferating;Protein Family;Protein Isoforms;Protein Kinase;protein protein interaction;protein structure;Proteins;Proteomics;Publications;receptor;Regulation;Reporter;Reporting;Repression;Research;Research Personnel;Research Project Grants;response;Role;Signal Transduction;small molecule inhibitor;structural biology;Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissues;Training;Transcription Coactivator;Tumor Suppressor Proteins;Validation;Western Blotting;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanism of Action of the TBX3 Gene in Breast Cancer


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Relevance to public health:  This work will test novel strategies to ameliorate NPC disease phenotypes and will establish an important role for oligodendrocyte lineage cells in NPC neuropathology. These findings are expected to set the stage for future efforts to translate new therapeutic approaches to patients with this disorder.

PI_NAMEs: LIEBERMAN, ANDREW P (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Affect;Age;Agonist;Alleles;autosome;Behavioral;Biochemical;Biological Models;Cell Lineage;Cell Maturation;Cells;Central Nervous System Diseases;Cessation of life;Characteristics;Childhood;Cholesterol;cholesterol trafficking;Clinical;Complement;Data;Defect;Development;Diagnosis;Disease;disease phenotype;Dose;drug development;dysmyelination;efficacy trial;FDA approved;Formulation;Future;Gene Expression;Genetic;Goals;Hepatomegaly;High Density Lipoproteins;Histologic;Human;humanized mouse;Impairment;In Vitro;Injections;innovation;knock-down;Knowledge;late endosome;Ligands;Lipids;loss of function mutation;Lysosomes;Maintenance;Medical;Membrane Glycoproteins;Missense Mutation;Modeling;Monitor;Mus;mutant;Mutant Strains Mice;Myelin;myelination;nanoparticle;Neimann-Pick's Disease Type C;Nerve Degeneration;nerve stem cell;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;neurotoxicity;novel strategies;novel therapeutic intervention;NPC1 gene;Nuclear RNA;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Pathogenesis;Pathway interactions;Patients;Peptides;Phenotype;preclinical efficacy;progressive neurodegeneration;protein folding;protein transport;Proteins;proteostasis;Public Health;Role;Series;small molecule;stem cells;Testing;Therapeutic;therapeutic target;Toxic effect;trafficking;transcription factor;transcriptome sequencing;Translating;Work

PROJECT_TITLE: Therapeutic Targets for Niemann-Pick Type C Neurodegeneration

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Human Genome;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Diagnostic tools, such as prenatal ultrasound and prenatal gene sequencing, have the capability to increase our understanding of fetal brain abnormalities (FBA). By intersecting human prenatal sequencing, bioinformatics filters to identify novel candidate genes, and functional modeling in an animal model, we aim to identify novel candidate genes specific to FBA; additionally, we will perform whole genome sequencing on a prospective cohort with FBA to increase our understanding of diagnostic yield and genotypes/phenotypes in a well characterized cohort. Our findings will shed light on the molecular underpinnings of human brain development and has the potential to improve pre- and postnatal counseling/management, and lead to novel preventive and therapeutic strategies that can be applied in the perinatal period.

PI_NAMEs: VORA, NEETA L (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Ablation;Adult;Affect;Age;Anatomy;Animal Model;Bioinformatics;bioinformatics tool;Biological Models;Body System;Brain;brain abnormalities;Candidate Disease Gene;candidate validation;Child;Clinical;Clinical Data;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Complement;Complex;Congenital Abnormality;Counseling;Coupled;CRISPR/Cas technology;Data;Defect;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;diagnostic value;Dideoxy Chain Termination DNA Sequencing;Dissection;Enrollment;Etiology;exome;exome sequencing;Family;fetal;fetal diagnosis;Fetus;Future;Gene Abnormality;gene discovery;Genes;Genetic;genetic analysis;Genetic Diseases;genetic disorder diagnosis;genetic testing;genome editing;genome sequencing;genome-wide;Genomics;Genotype;Healthcare Systems;Heterogeneity;Holoprosencephaly;Human;human disease;human model;Hybrids;Image;improved;in utero;in vivo;in vivo Model;Infant;knock-down;Knowledge;Larva;Lesion;Life;Link;Live Birth;Magnetic Resonance Imaging;member;Mendelian disorder;Messenger RNA;Modeling;Molecular;Molecular Diagnosis;Morbidity - disease rate;Multiple Abnormalities;Neural Cell Adhesion Molecule L1;new technology;Newborn Infant;novel;novel therapeutics;Operative Surgical Procedures;Orthologous Gene;Parents;Pathogenicity;perinatal period;Phenotype;phenotypic data;Physiological;Population;Population Genetics;postnatal;prenatal;Prenatal Diagnosis;Prevention strategy;Preventive;proband;Process;Prognosis;prospective;Prospective cohort;protein function;rare variant;Recurrence;Retrospective cohort;Risk;RNA Splicing;segregation;Site;stem;Structure;Testing;Therapeutic;therapeutic target;tool;Traction;Ultrasonography;ultrasound;United States;Variant;whole genome;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: Genomics and functional dissection of fetal brain abnormalities using a prenatal cohort

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE The goal of this University of Rochester Medical Center Post-baccalaureate Research Education Program (URMC-PREP) is to prepare, promote, and continually assist the successful transition and retention of promising scholars from underrepresented groups (URGs) into rigorous biomedical research doctoral degree programs and pursue successful careers in biomedical sciences. These scholars will add diversity to the biomedical research workforce, enrich perspectives on health related research, and ultimately improve how health care is delivered.

PI_NAMEs: ROBERT, JACQUES  (contact);SMOLOCK, ELAINE M

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;Achievement;Advocacy;Attitude;Belief;Biomedical Research;career;Collaborations;Committee Members;Communication;Communities;Competence;Country;deaf;Degree program;design;Development;Development Plans;Discipline;Doctor of Philosophy;Doctor's Degree;Education;education pathway;education research;educational atmosphere;Educational workshop;Environment;Evaluation;expectation;faculty mentor;Faculty Workshop;flexibility;Fostering;Goals;Graduate Education;graduate school;Graduation Rates;hard of hearing;Health;Healthcare;implicit bias;improved;improved outcome;Individual;innovation;Institution;Knowledge;Laboratories;Leadership;leadership development;Learning;Letters;Logic;matriculation;Medical center;meetings;member;Mentors;Mentorship;Minority Groups;Modeling;Outcome;peer;peer coaching;Persons;Positioning Attribute;Postbaccalaureate;Professional Competence;Professional Education;Program Development;programs;Readiness;recruit;Rejuvenation;Research;Research Project Grants;Research Training;Resources;Scholars Program;Science;Security;Self Assessment;Series;skills;Solid;success;Supervision;symposium;System;Teacher Professional Development;Technology;Training;Training and Education;Training Programs;Underrepresented Minority;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: University of Rochester Medical Center PREP Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Prevention

PHR: NARRATIVE The well-established technologies of spectroscopic photoacoustic imaging and ultrasound elastography, and our novel PA-US imaging technology are promising tools for the measurement of molecular and mechanical biomarkers of intestinal inflammation and fibrosis. The proposed endoscopic photoacoustic-ultrasound dual modality imaging procedure will, for the first time, facilitate the comprehensive assessment of intestinal inflammation and fibrosis in Crohn’s disease intestinal strictures.

PI_NAMEs: HIGGINS, PETER D.R. (contact);XU, GUAN

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: absorption;accurate diagnosis;Acute;Affect;Animal Model;Animals;Anti-Inflammatory Agents;Balloon Dilatation;Biological Markers;Biopsy;Catheters;Chronic;chronic autoimmune disease;Clinical;Clinical Management;clinical translation;clinically relevant;Collagen;Colonoscopes;Complement;Crohn's disease;Diagnostic;Diagnostic Imaging;Diagnostic Procedure;Digestive System Disorders;Disease;elastography;Endoscopic Biopsy;Endoscopy;Excision;experimental study;Extracellular Matrix;Fibrosis;Future;Gastroenterology;Genes;gut inflammation;Hemoglobin;Histopathology;Human;human subject;human tissue;Hyperplasia;Hypertrophy;Image;imaging approach;imaging biomarker;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;in vivo Model;Inflammation;Inflammatory;innovation;instrument;Intestinal Diseases;Intestinal Fibrosis;Intestinal Obstruction;Intestines;Length;Magnetic Resonance Imaging;Measurement;Mechanics;Modality;Modeling;Molecular;molecular marker;molecular pathology;Monitor;Morphology;Mucous Membrane;Multivariate Analysis;Muscle;Myofibroblast;novel;Operative Surgical Procedures;Optics;Oryctolagus cuniculus;Outcomes Research;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Penetration;Performance;personalized therapeutic;Persons;Phenotype;photoacoustic imaging;Pilot Projects;pressure;Procedures;prognosis biomarker;prognostic;Publishing;Research;Resected;Sampling;Sensitivity and Specificity;Signal Transduction;Small Intestines;Stenosis;Submucosa;success;Techniques;Technology;Testing;Time;Tissue Sample;Tissues;tool;Translations;Ultrasonic Transducer;ultrasound;United States;X-Ray Computed Tomography

PROJECT_TITLE: Assessing biomarkers of intestinal fibrosis and inflammation in Crohn's Disease via an endoscopic imaging catheter

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Cardiovascular disease is the leading cause of death and disability in industrialized nations and its prevalence is rising rapidly in developing nations. Current therapies for cardiovascular disease are aimed at treating the symptoms rather than repairing the damaged myocardial tissue. This proposal aims to elucidate the underlying molecular and cellular mechanisms of the cardiac regenerative response in order to strategically design new potential therapeutics.

PI_NAMEs: CUI, MIAO  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Adipose tissue;Adult;Affect;American;Antioxidants;Attenuated;Biological;biological adaptation to stress;Brain;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardioprotection;Cardiovascular Diseases;cardiovascular disorder therapy;Cardiovascular system;career;career development;Cause of Death;Cell Nucleus;Cellular Stress;Clinical;Complement;Complex;Cytoprotection;Data;Dedications;design;Developed Countries;Developing Countries;disability;Disease;Endoplasmic Reticulum;Equilibrium;Erythroid;experience;experimental study;Functional disorder;Gene Delivery;Genes;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;In Vitro;in vivo;in vivo regeneration;Injury;insight;Investigation;ischemic injury;knock-down;Knock-out;Knockout Mice;Laboratories;Liver;Measures;Mediating;Mentors;Modeling;Molecular;multicatalytic endopeptidase complex;Mus;myocardial damage;Myocardial Infarction;Myocardial Ischemia;Myocardial tissue;Myocardium;Natural regeneration;Neonatal;neonatal mice;Newborn Infant;novel;Nuclear;overexpression;Oxidation-Reduction;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Phase;Phenotype;Population;Positioning Attribute;Prevalence;programs;Proliferating;proteostasis;Public Health;Recovery;regeneration following injury;regenerative;Regenerative capacity;Regenerative response;regenerative tissue;repaired;Reperfusion Therapy;Research;response;response to injury;restoration;Role;Science;single nucleus RNA-sequencing;Stress;symptom treatment;Therapeutic;tissue repair;Tissues;tool;Training;transcription factor;transcriptome;transcriptomic profiling;treatment strategy

PROJECT_TITLE: Dissecting the cytoprotective role of NRF1 in heart regeneration and repair


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Autism Spectrum Disorder (ASD) is diagnosed at a rate of four males to one female; however as research has identified and included more females, a number of important differences have emerged between males and females. The majority of prior research has only studied autistic males and females at one timepoint, therefore there is a critical gap in our understanding of the early developmental trajectories of autistic females that can only be addressed through longitudinal research. This R01 will address this need and examine how autistic males and females differ in early childhood (4 to 8 years) using a novel longitudinal design and across measurement approaches to understand early sex differences and gender diversity in ASD.

PI_NAMEs: HARROP, CLARE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Address;Adolescence;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;aged;autism spectrum disorder;autistic;autistic children;Behavior;Behavioral;Biological Assay;biological sex;Birth;Characteristics;Child;Classification;Cognition;cohort;Data;Development;Diagnosis;Diagnostic;diagnostic signature;early childhood;Early identification;Early Intervention;Eligibility Determination;Etiology;executive function;Exhibits;experience;externalizing behavior;Feeling suicidal;Female;Friendships;Functional disorder;Gender;gender difference;gender diverse;gender diversity;Gender Identity;Gestures;Goals;Individual;individuals with autism spectrum disorder;innovation;interest;International;Intervention;Knowledge;Linguistics;Link;Longitudinal cohort;longitudinal design;Longitudinal Studies;male;Measurement;Measures;Mental Depression;Mental Health;Methodology;Methods;Modality;Modeling;Motivation;multimodality;Neuropsychology;novel;Outcome;Parents;Patient Self-Report;Pattern;Phenotype;Play;Positioning Attribute;protective effect;recruit;repetitive behavior;Reporting;Research;Risk;Role;Sampling;Series;sex;sex assigned;Sex Differences;Site;Smiling;social;social attention;Special needs;therapy design;Time;Variant;visual tracking;women's diagnosis;Work

PROJECT_TITLE: Sex, Gender, and Camouflage in Autism Spectrum Disorder: A Multimodal, Accelerated Longitudinal Design

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Kidney Disease;Regenerative Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: During times of severe illness, the kidneys can suffer injury and stop functioning. As the patient improves, the cells in the kidney can regenerate and restore kidney function, a process that requires macrophages to change from a pro-injury state to a pro-repair state. This grant studies how those macrophages change to a repair state, and what signals they use to help kidney repair so that we can develop better therapies to restore kidney function.

PI_NAMEs: CANTLEY, LLOYD G (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Amino Acids;arginase;Catabolism;Cell Communication;Cell Death;Cell Proliferation;Cell Separation;Cell Survival;Cells;Cellular Metabolic Process;Clinical;Creatinine;Cytometry;Data;Development;Dichloromethylene Diphosphonate;Drug Metabolic Detoxication;Epithelium;Female;gene repair;Genes;Grant;Growth Factor;Histologic;Homing;Image;Immunofluorescence Immunologic;improved;improved outcome;In Vitro;in vivo;Individual;inhibitor;injured;Injury;Injury to Kidney;Innate Immune System;Kidney;kidney medulla;kidney repair;knock-down;Knock-out;Knockout Mice;Ligands;Limb structure;Liposomes;Location;Macrophage;Macrophage Activation;male;Maps;Metabolic;mimetics;monocyte chemoattractant protein 1 receptor;Mononuclear;mortality;multi-photon;multiphoton imaging;Mus;Natural regeneration;operation;Output;Pathway interactions;Patients;Phagocytes;pharmacologic;phosphoproteomics;Play;Population;prevent;Process;Proliferating;Proteomics;receptor;Recovery;recruit;Renal function;renal ischemia;Renal Replacement Therapy;Renal tubule structure;repaired;Reperfusion Injury;Resolution;response;Role;screening;selective expression;Signal Transduction;single-cell RNA sequencing;Site;therapeutic target;Thinness;Time;Tubular formation;Validation;Wild Type Mouse

PROJECT_TITLE: Macrophage Function in Kidney Repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Rotaviruses are one of the most important causes of severe diarrheal illness in infants and young children. Despite the availability of multiple vaccines, rotavirus gastroenteritis is responsible for an estimated 215,000 deaths every year. Our proposed studies of rotavirus-host entry factor interactions will facilitate the rational design of novel vaccines and therapeutics against rotavirus, thereby reducing the overall infection-associated morbidity and mortality.

PI_NAMEs: DING, SIYUAN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adsorption;Affinity Chromatography;Age;Amino Acids;Animal Model;Anti-viral Agents;Antigens;Apical;B-Lymphocytes;Binding;Binding Sites;Biological Assay;Biotin;Blood Group Antigens;Capsid;Cell Line;Cell Separation;Cells;Cessation of life;Chemicals;Child;Clinical;Co-Immunoprecipitations;Colon;Complex;Country;CRISPR screen;CRISPR/Cas technology;Crystallography;cyanine dye 5;Data;data modeling;Dependence;design;Diarrhea;diarrheal disease;Distant;Enterocytes;Enteroendocrine Cell;Epidemiology;Epithelial Cells;Epitopes;Escape Mutant;Etiology;Event;EXTL3 gene;Flow Cytometry;Gastroenteritis;Genes;Genetic Screening;genome-wide;Head;Heparitin Sulfate;high throughput screening;HT29 Cells;Human;human monoclonal antibodies;improved;in vivo;in vivo Model;Incubated;infancy;Infant;Infection;innovation;Integral Membrane Protein;Integration Host Factors;intestinal epithelium;Intestines;kidney epithelial cell;Knock-out;Knowledge;Label;Ligation;Lymphocyte;Maps;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Molecular;Monkeys;Monoclonal Antibodies;monolayer;Morbidity - disease rate;mortality;mouse model;neutralizing monoclonal antibodies;Norovirus;novel therapeutics;novel vaccines;Organoids;Outcome;Persons;Polysaccharides;Preventive vaccine;Proteins;Proteomics;rational design;receptor;Recombinants;Reporter;reverse genetics;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Route;Sialic Acids;Side;Small Intestines;Structural Protein;suckling;Surface;System;Therapeutic;tool;Transmission Electron Microscopy;Tropism;Vaccines;Viral;Virion

PROJECT_TITLE: Mechanism of Rotavirus Entry

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: CRISPR/Cas systems are exponentially growing as gene and RNA editing and detection technologies with a huge potential for applications in diagnosis and treatment of a range of genetic diseases. The proposed research will lead to the discovery, understanding, and engineering CRISPR/Cas systems to solve challenging issues of lower efficiency, poor specificity, and lack of control. A deeper understanding and development of next generation of CRISPR/Cas technologies for diagnosis and treatment of diseases would have a transformative impact to a wider research community across multiple disciplines, institutes and centers of the NIH.

PI_NAMEs: JAIN, PIYUSH K (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Award;base editing;BCAR1 gene;Biological Models;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Communicable Diseases;Communities;CRISPR/Cas technology;Detection;Development;Diagnosis;Diagnostic;Discipline;Disease;DNA;Engineering;Enzymatic Biochemistry;Enzymes;gene correction;Genes;Genetic Diseases;genome editing;Genome engineering;Image;improved;Malignant Neoplasms;Metagenomics;microorganism;Mining;next generation;novel;nuclease;nucleic acid detection;Orthologous Gene;Outcome;programs;Publications;Research;Research Personnel;RNA;RNA Editing;Running;Specificity;Structure-Activity Relationship;System;Technology;Testing;tool;Training Programs;United States National Institutes of Health

PROJECT_TITLE: Discovery and engineering of CRISPR/Cas systems

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE Acute exposure to nerve agents induces status epilepticus (SE), which compounds the peripheral cholinergic crisis, leading to death or significant brain damage and long-term neurological morbidities. Treatment of nerve agent-induced SE with diazepam—the anticonvulsant approved by the FDA for this indication— or midazolam, which is considered to be a better alternative to diazepam and may soon replace it, does not exert good control of SE and has minimal neuroprotective effects. We have discovered an antiglutamatergic therapy to suppress hyperexcitability and excitotoxicity—consisting of LY293558, an AMPA/GluK1 receptor antagonist, and caramiphen, an antimuscarinic compound that also antagonizes NMDA receptors—which provides full neuroprotection in immature rats, administered 1 h after soman exposure, and we are proposing to test the antiseizure and neuroprotective efficacy of this two-component combination therapy in young-adult and aged male and female rats exposed to soman, in comparison with the corresponding efficacy of midazolam.

PI_NAMEs: BRAGA, MARIA F. (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acetylcholinesterase;Acute;Adult;Adult women;Advanced Development;aged;Amygdaloid structure;antagonist;Anticonvulsants;Anxiety;anxiety-like behavior;Appearance;Applications Grants;Atrophic;Behavioral;Benzodiazepines;Brain;Brain Injuries;Brain Pathology;Caring;Cessation of life;chemical threat;Chemical Weapons;cholinergic;Clinical;Combined Modality Therapy;Communication;cost;Data;Deterioration;Development;Diazepam;Drug Kinetics;Effectiveness;efficacious treatment;efficacy evaluation;Elderly;Electroencephalography;Epileptogenesis;excitotoxicity;Exposure to;FDA approved;Female;Funding;Glutamates;Goals;Grant;Hippocampus;Interneurons;Joints;Lead;Legal patent;Licensure;life span;Longitudinal Studies;Magnetic Resonance Imaging;male;Measures;Medical;medical countermeasure;Midazolam;Military Personnel;Morbidity - disease rate;Muscarinics;N-Methyl-D-Aspartate Receptors;National Institute of Allergy and Infectious Disease;Nature;nerve agent;Nerve Degeneration;Neurologic;neuron loss;neuropathology;neuroprotection;NMDA receptor antagonist;Organophosphorus Compounds;Peripheral;Population;postnatal;pre-clinical;pre-clinical research;prevent;Property;Rattus;receptor;receptor internalization;Recurrence;Research;Risk;Seizures;Soman;Status Epilepticus;Survival Rate;Synaptic Transmission;Technology Transfer;Terrorism;Testing;Time;Toxic effect;War;Work;young adult

PROJECT_TITLE: Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(50)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Diabetes is the fastest growing epidemic in the western world and is characterized by high levels of blood sugar, which reacts non-enzymatically with cellular proteins in a process called glycation. We recently found that glycation specifically accumulates on histones, inducing significant changes in chromatin architecture and subsequent cellular transcription. The proposed research project will comprehensively examine the molecular mechanisms of histone glycation, elucidate its contribution to abrogated chromatin structure and function, and finally characterize repair mechanisms that will open new avenues for therapeutic development in both diabetes and cancer.

PI_NAMEs: DAVID-SHTERNBERG, YAEL E (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Architecture;Arginine;Biochemical;Biological;Biophysics;Blood Glucose;Cells;Chemicals;Chromatin;Chromatin Structure;Communication;crosslink;Diabetes Mellitus;Disease;DNA;Epidemic;Epigenetic Process;Eukaryota;Gene Expression;Genes;Genetic;Genetic Transcription;glycation;Higher Order Chromatin Structure;Histone Code;histone modification;Histones;In Vitro;in vivo;insight;interdisciplinary approach;Link;Malignant Neoplasms;Methods;Modification;Molecular;Nature;novel therapeutics;PARK7 gene;Post-Translational Protein Processing;Process;programs;Proteins;Reaction;Reader;repaired;Repression;Research Project Grants;Resolution;response;Site;Stimulus;therapeutic development;Transcriptional Regulation;Western World;Work

PROJECT_TITLE: Investigating histone glycation as a new dynamic epigenetic mark

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(07)R]