NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide us with fundamental knowledge of the intra-tick and intra-host infection biology of the tick-borne bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). Due to its high case fatality rate, ability to cause hemorrhagic disease, and lack of specific treatment strategies, SFTSV is considered a priority infectious disease by the World Health Organization. Elucidating the basic infection biology of SFTSV within the Haemaphysalis longicornis tick and within the skin of the vertebrate host will lay the foundation towards developing novel interventions that disrupt SFTSV transmission and survival.

PI_NAMEs: HERMANCE, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: arthropod-borne;Asia;Basic Science;Behavioral;Biology;Blood;Bunyavirales;Bunyavirus Infections;Case Fatality Rates;Cells;Characteristics;Climate;Communicable Diseases;Cutaneous;Data;Development;Digestion;Disease;Distal;Ecosystem;Environment;epidemic potential;Event;Far East;feeding;Feeds;Fever;Foundations;Future;Geography;Germ Cells;Haemaphysalis longicornis;Hemocytes;Hemorrhage;Hour;Immune response;Immunologics;in vivo;Incidence;Infection;Infectious Skin Diseases;Inflammatory;Intervention;invertebrate host;Kinetics;Knowledge;Life;Life Cycle Stages;Midgut;Modeling;Molting;Natural regeneration;Nature;novel;novel strategies;Organ;Orthobunyavirus;Physiological;Population;prevent;Process;Public Health;Publications;Publishing;Reproduction;Request for Applications;Research;Research Proposals;response;Role;Salivary Glands;Severe Fever with Thrombocytopenia Syndrome Virus;Site;Skin;Syndrome;Testing;Thrombocytopenia;tick feeding;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne flavivirus;tick-borne virus;Ticks;Time;timeline;Tissues;transmission process;treatment strategy;Tropism;United States;vector tick;Vertebrate Viruses;Viral Load result;viral transmission;Virus;Virus Diseases;virus host interaction;Work;World Health Organization

PROJECT_TITLE: Intra-tick and intra-host infection dynamics of a tick-borne bunyavirus


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We will optimize the combination of an exceptionally broad and potent HIV-1 entry inhibitor and a tunable hydrogel that significantly extends the in vivo half-life of this inhibitor. This combination could provide PrEP-like protection or ART-like viral control for six months or more.

PI_NAMEs: APPEL, ERIC ANDREW;FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adeno-associated viral vector;Adverse event;Animals;Antibodies;antibody mimetics;antiretroviral therapy;Biochemical;Biological;Biological Products;biophysical properties;Cell Culture Techniques;Cells;Collaborations;Conscious;Control Animal;cost;demographics;Dependovirus;Dose;Drug Kinetics;Drug resistance;Event;fitness;Formulation;Half-Life;Healthcare;HIV-1;HIV-2;Human;Hydrogels;immunogenic;immunogenicity;Implant;improved;in vivo;Individual;Infection;Infrastructure;inhibitor;Injectable;Injections;Intramuscular;intravenous administration;Laboratories;Macaca;Macaca mulatta;manufacture;Mediating;Modeling;Mus;Needles;neonatal Fc receptor;neutralizing antibody;novel;Pathway interactions;Patients;Peptides;Persons;Population;pre-exposure prophylaxis;Preparation;prevent;Property;Prophylactic treatment;protein aggregation;Proteins;receptor;Rectum;Serum;Serum Proteins;sexually active;side effect;simian human immunodeficiency virus;SIV;Stigmatization;System;Testing;Therapeutic;Tissues;Toxic effect;Transgenes;Transgenic Mice;transmission process;Variant;Viral;Virus

PROJECT_TITLE: An injectable hydrogel platform for sustained release of eCD4-Ig

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Cerebrovascular;Endocannabinoid System Research;Neurosciences;Sleep Research;Stroke

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PI_NAMEs: BRIDI, MICHELLE  (contact)

PROJECT_TERMS: Acute;Affect;Agonist;Animals;antagonist;Area;Arousal;Automobile Driving;Behavioral;behavioral outcome;Bilateral;Blood flow;Brain;Brain region;C-terminal;Cannulas;Cells;Centers of Research Excellence;Cephalic;Cessation of life;Chlorides;Chronic;Collection;Compensation;Complex;Dependence;disability;Distant;Dominant-Negative Mutation;Electroencephalography;endocannabinoid signaling;Endocannabinoids;epileptiform;Evolution;Excitatory Synapse;experimental study;extrastriate;Failure;Fiber;Fiber Optics;Frequencies;Future;GABA Receptor;gamma-Aminobutyric Acid;Glutamates;Homeostasis;Hour;Human;human data;Impairment;Implant;Implanted Electrodes;improved;in vivo;Infarction;insight;Interneurons;Ipsilateral;Ischemia;Ischemic Stroke;Laser Speckle Imaging;Left;Lesion;Light;Lighting;Measures;Methods;Middle Cerebral Artery Occlusion;Modeling;Moderate Activity;Modification;Monitor;Motor Cortex;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nature;Nervous System Physiology;Neurologic;neuron loss;Neurons;non rapid eye movement;optical fiber;Oranges;osmotic minipump;Outcome;patch clamp;Pathologic;Pattern;Periodicity;pharmacologic;Phase;Photobleaching;Photometry;Population;Positioning Attribute;post stroke;postsynaptic;presynaptic;prevent;Prosencephalon;rapid eye movement;Recovery;REM Sleep;Reporter;Reporting;response;Rodent;Role;Rosaniline Dyes;Sensory Deprivation;Signal Transduction;Site;Sleep;Sleep disturbances;Sleep Fragmentations;sleep pattern;sleep quality;Slice;Slide;Somatosensory Cortex;spatiotemporal;Stains;Stroke;stroke outcome;stroke survivor;subcutaneous;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Tertiary Protein Structure;Testing;Time;Tissues;Titrations;Universities;vector;Viral;Visual;visual discrimination;West Virginia

PROJECT_TITLE: Effects of stroke on cortical synaptic function


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke

PHR: This project will establish a human specific model of the blood-brain barrier in stroke, allowing for increased  understanding of how brain vasculature responds to an ischemic stroke. It will also result in the  identification of antibodies that target the ischemic brain for improved efficiency of drug delivery.

PI_NAMEs: KATT, MORIAH  (contact)

PROJECT_TERMS: 3-Dimensional;ABCB1 gene;Acclimatization;Acute;Address;Alteplase;Analysis of Variance;Animal Model;Animals;Antibodies;antibody libraries;antibody test;Apical;Apoptosis;aquaporin 4;Architecture;Area;Astrocytes;Autopsy;Basal lamina;Benchmarking;Binding;Biodistribution;Biological Assay;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier crossing;blood-brain barrier function;Brain;Brain Ischemia;Brain region;Brain-Derived Neurotrophic Factor;Cadaver;candidate identification;Carbon Dioxide;CASP3 gene;cell immortalization;Cell Line;cell motility;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Morphology;Centers of Research Excellence;Central Nervous System Diseases;Cerebrovascular system;Cessation of life;Chimeric Proteins;Chinese Hamster Ovary Cell;Chronic;Chronic Phase;chronic stroke;Clinic;Clinical;Clinical Trials;Collagen;Collagen Type IV;Communities;Confidence Intervals;Contralateral;Control Groups;Coupled;CRISPR interference;cross reactivity;Data;Data Analyses;density;deprivation;design;design and construction;Detection;Development;Devices;Dextrans;Diameter;disability;Disease;Disease Progression;disulfide bond;Dose;Drug Delivery Systems;Drug Transport;efficacy testing;Electrical Resistance;Endothelial Cells;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;Excision;experimental study;Exposure to;Extracellular Matrix;fabrication;Failure;Fc Immunoglobulins;FDA approved;Fibronectins;field study;Flow Cytometry;Gel;Generations;Glass;Glial Fibrillary Acidic Protein;Glucose;Growth;Growth Factor;Guide RNA;Health;Hour;Housing;Human;human disease;human induced pluripotent stem cells;human model;human tissue;Hyaluronic Acid;Hydrogels;Hypoxia;Immunoglobulin G;Immunoprecipitation;improved;In Situ Nick-End Labeling;In Vitro;in vitro Model;Incubated;Individual;induced pluripotent stem cell;Infarction;inflammatory marker;Injections;Injury;insight;Insulin Receptor;Intravenous;Ipsilateral;Ischemia;Ischemic Stroke;Label;Laminin;Lead;lead candidate;Length;Leukocytes;Libraries;Ligands;Liposomes;live cell microscopy;lucifer yellow;Lymphocyte;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Mediating;Methods;Microfluidic Microchips;Microscopy;Modeling;Monitor;monolayer;Morphology;Motility;Motor;mouse model;Mus;Mutagens;Names;Nature;Neurites;Neuroglia;neuroinflammation;neuronal growth;Neurons;neuroprotection;Neuroprotective Agents;non-invasive imaging;normoxia;Nutrient;Nutrient availability;occludin;Organ;Outcome;overexpression;Oxygen;Patients;PC12 Cells;Penetration;Perfusion;Permeability;Persons;Phage Display;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physiological;placebo group;Plasmids;polydimethylsiloxane;power analysis;preclinical study;prevent;Production;protein folding;Proteins;Pump;Quality of life;receptor;Recovery;recruit;Rehabilitation therapy;Reperfusion Therapy;Reporting;Resected;response;Rhodamine;Rhodamine 123;Risk;Rod;Rodent;Running;Scheme;screening;shear stress;side effect;Slide;small molecule therapeutics;Source;Specificity;spheroids;Stains;stem cell model;stem cells;Stroke;stroke model;stroke recovery;stroke therapy;success;Supporting Cell;Surface;symptom management;System;targeted treatment;Tariquidar;Techniques;Testing;TFRC gene;Therapeutic;Tight Junctions;Time;Tissue Sample;Tissues;Tracer;trafficking;transcytosis;Transfection;Translating;translational therapeutics;transport inhibitor;Traumatic Brain Injury;Tubulin;United States National Institutes of Health;Universities;uptake;Validation;Vascular Endothelium;vector;Visualization;West Virginia;Western Blotting;Work;Yeasts

PROJECT_TITLE: Identifying targeting antibodies in an in vitro model of the human blood-brain barrier during ischemic stroke


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Stroke

PI_NAMEs: BRIDI, MORGAN STUART (contact)

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Adrenal Gland Hyperfunction;Adrenal Glands;Agonist;Animals;antagonist;Antibody Therapy;Behavioral;behavioral outcome;Bilateral;biological adaptation to stress;Biological Assay;Brain;Calcium;Cell Nucleus;Centers of Research Excellence;Chemosensitization;Chronic;Chronic Phase;Clozapine;Color;Corticosterone;Corticotropin-Releasing Hormone;designer receptors exclusively activated by designer drugs;Development;excitotoxicity;falls;Feedback;Fiber;functional improvement;functional outcomes;gamma-Aminobutyric Acid;Genetic;Glutamates;Hippocampus;hormonal signals;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;improved;Incidence;Infarction;Injury;Intervention;Ischemia;Ischemic Stroke;Long term disability;Measures;Middle Cerebral Artery Occlusion;Morbidity - disease rate;mortality;Mus;Nerve Degeneration;Neurons;Neurosecretory Systems;neurovascular injury;novel therapeutics;osmotic minipump;Outcome;Oxides;paraventricular nucleus;Pattern;Phase;Photometry;Pituitary Gland;Plasma;Population;post stroke;Production;Regulation;Reporter;sensor;sex;Signal Transduction;stem;Stress;stress reactivity;stressor;Stroke;stroke outcome;Structure of terminal stria nuclei of preoptic region;Survivors;Synapses;Time;Universities;West Virginia

PROJECT_TITLE: Measuring and manipulating stress-responsive neuronal activity to improve post-stroke outcomes


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Chronic Pain;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Over 90% of individuals worldwide have been infected by varicella zoster virus (VZV), the cause of chickenpox. VZV remains dormant in the nervous system and, when it reactivates, can cause the painful condition shingles or debilitating neurologic conditions such as brain or spinal cord inflammation (encephalitis and myelitis). Here, we propose to use new stem-cell based models to investigate pathways within neurons that contribute to persistence and reactivation.

PI_NAMEs: VENKATESAN, ARUN  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acyclovir;Address;Affect;Afferent Neurons;Animal Model;Anti-viral Agents;Autopsy;Axon;Brain;cell type;Cells;Chickenpox;ChIP-seq;Chromatin;Chronic;Complication;cost;Data;demethylation;Development;DNA Viruses;Encephalitis;Epigenetic Process;experience;Experimental Models;fetal;Fibroblasts;Gene Activation;Gene Expression;Genes;Genetic Transcription;Herpes zoster disease;Herpesvirus 1;Herpesvirus Type 3;Histone H3;histone methylation;Histones;Human;human disease;human embryonic stem cell;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infection;Infectious Encephalitis;insight;Kinetics;latency associated transcript;Lytic;microfluidic technology;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Myelitis;nerve stem cell;Nervous System;Neurologic;Neurons;Neuropathogenesis;Nociceptors;novel strategies;novel therapeutics;Pain;painful neuropathy;Pathogenesis;Pathway interactions;permissiveness;Persons;Phase;Postherpetic neuralgia;Primary Infection;Process;promoter;reactivation from latency;RNA marker;Simplexvirus;single-cell RNA sequencing;Skin;Species Specificity;Specimen;Spinal Ganglia;stem cell based approach;stem cell model;stem cells;Syndrome;System;Tissues;transcriptome sequencing;Vaccination;Viral;viral DNA;Viral Pathogenesis;Viral Proteins;Virus;Virus Activation;Virus Diseases;Virus Latency;Xenograft procedure

PROJECT_TITLE: Mechanisms of Varicella Zoster Virus Latency in Human Sensory Neurons

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative There remains a need for novel research that facilitates responsible reporting back of research results (RBRR) in a manner that raises data and environmental health literacy and supports communities striving for environmental health and structural change. Rooted in bioethics, the program focuses on how to report back social determinants of health and soil and air quality data with rural and urban communities that are disproportionately impacted by pollution. Building upon trusted and established long-term partnerships and leveraging existing datasets, the project goal is to create and pilot a national model of report back that engages diverse environmental justice communities to ensure that RBRR reaches all populations in a manner tailored to their individual needs, including culture, life stage, language, and design.

PI_NAMEs: RAMIREZ-ANDREOTTA, MONICA D. (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;African American;Air;Assessment tool;Awareness;Back;Bioethics;Black race;Cessation of life;Communication;Communities;community organizations;community partners;Credentialing;Data;data literacy;Data Reporting;Data Set;design;Disease;Economics;efficacy evaluation;Elements;Ensure;Environmental Health;environmental justice;Environmental Risk Factor;Equity;Ethics;Ethnic Origin;Evaluation;formative assessment;Goals;Government Agencies;Health;health disparity;health equity;health literacy;Hispanic;Individual;innovation;Institutional Review Boards;Justice;Knowledge;Language;learning outcome;Life;literacy;Literature;Local Government;mathematical ability;Mediator;member;Methods;Mining;Modeling;Morals;novel;Outcome;Politics;Pollution;Population;premature;Process;Professional counselor;programs;prototype;Race;Reporting;Research;Risk;Role;Rural;Rural Community;Self Efficacy;skills;social;social health determinants;sociodemographic variables;Soil;structural determinants;tool;Training;Translating;Trust;Urban Community

PROJECT_TITLE: Disentangling the role of culture, life stage, and information design to facilitate equity in data report back

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury

ORG_CITY: GREENVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of this research program is to determine the role, the Kcnn1 potassium channel plays during recovery from spinal cord injury. We are combining in vivo imaging with state of the art optogenetic and CRISPR/Cas9-medidate techniques to generate stable zebrafish lines to understand the molecular mechanisms that underlie these neuronal processes. These lines will then be used in high- throughput screening to identify potential therapeutic targets.

PI_NAMEs: MRUK, KAREN  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 4-Aminopyridine;Adult;Animal Model;Bioinformatics;Calcium;Calcium-Activated Potassium Channel;calcium-activated potassium channel small-conductance;Cardiac;cell type;Cells;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR/Cas technology;Data;Development;Developmental Biology;Diabetes Mellitus;differential expression;Disease;Drug Screening;Epilepsy;Family;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;gene function;Genes;Genetic Transcription;Goals;Heart Atrium;high throughput screening;Human;Immunofluorescence Immunologic;In Situ Hybridization;in vivo imaging;inhibitor;Injury;insulin secretion;interest;International;Ion Channel;Knock-out;knockout gene;Laboratories;Light;Locomotor Recovery;loss of function;Mediating;Methods;Modeling;Molecular;mutant;Natural regeneration;Nervous System;Nervous System Trauma;Neurodegenerative Disorders;neurological pathology;Neurons;novel therapeutics;oligodendrocyte progenitor;optogenetics;Organ;overexpression;paralogous gene;Periodicity;Peripheral Nervous System;pharmacologic;Phenotype;Physiology;Play;Positioning Attribute;Potassium;Potassium Channel;potassium ion;precursor cell;Process;programs;Proteins;Publishing;Reagent;Recovery;Recovery of Function;Renal function;Reporting;Research;Resources;Role;Sensory;spatiotemporal;Spinal Cord;Spinal cord injury;Swimming;System;Techniques;Technology;Therapeutic;therapeutic target;Tissues;tool;Transcript;Transgenic Organisms;voltage;Zebrafish

PROJECT_TITLE: Elucidating the role of kcnn1 in recovery from spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Family psychoeducation for adults living with psychotic disorders in Tanzania (KUPAA Trial) The proposed research is relevant to public health because the mental health needs of individuals with psychotic disorders in low-resource countries have been severely neglected, due in part to a lack of culturally tailored and evidence-based interventions. Family psychoeducation (FPE) is an evidence-based practice from high-income countries that could have a significant impact in settings such as Africa and other regions worldwide where resources are limited, families are largely responsible for care and support, and traditional beliefs and treatments are common. This R01 will test the effectiveness and mechanisms of action of a newly adapted and culturally tailored version of FPE called KUPAA for adults living with psychotic disorders in Tanzania which aligns with NIMH Strategy 4.2.B, “Building models to scale-up evidence-based practices for use in public and private primary care, specialty care, and non-traditional settings.”

PI_NAMEs: BAUMGARTNER, JOY NOEL (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Adult;Affect;Africa;aged;Ally;Ambulatory Care;Belief;burden of illness;Caregiver Burden;Caregivers;Caring;Client;Clinic;clinical trial implementation;Clinical Trials;cohort;Collaborations;college;common treatment;Communities;Competence;Consolidated Framework for Implementation Research;coping;cost;Country;Data;design;disability;Educational Curriculum;effectiveness evaluation;effectiveness testing;effectiveness trial;effectiveness/implementation hybrid;Evidence based intervention;Evidence based practice;Family;family burden;Family member;Feedback;Goals;Health;Health care facility;Health Personnel;Health Resources;Hospital Referrals;Hospitalization;Hospitals;Hybrids;implementation evaluation;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Income;Individual;insight;Institution;Intervention;intervention cost;Interview;low and middle-income countries;low income country;Mediator;Medical;medical specialties;Mental disorders;Mental Health;Mental Health Services;Methods;model building;Modeling;National Institute of Mental Health;neglect;North Carolina;Outcome;participant retention;Patients;Persons;pilot test;pilot trial;Population;Primary Care;primary outcome;Privatization;Problem Solving;Provider;psychoeducation;psychosocial;Psychotic Disorders;Public Health;Quality of life;Randomized;Recommendation;Recovery;recruit;relapse prevention;Research;Research Priority;Resource-limited setting;Resources;response;scale up;Schizophrenia;schizophrenia spectrum disorder;Science;secondary outcome;Site;standard of care;Standardization;Structure;Tanzania;Testing;Therapeutic;therapy design;Training;treatment group;treatment guidelines;treatment trial;Universities;uptake

PROJECT_TITLE: Family Psychoeducation for Adults with Psychotic Disorders in Tanzania (KUPAA trial)

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Social Determinants of Health

ORG_CITY: NEWTON

ORG_NAME: SILENT SPRING INSTITUTE

PHR: Project Narrative The emerging science of the exposome – the totality of non-genetic exposures across the life cycle -- is a crucial new direction for research to foster healthy families and prevent later-life chronic disease. Assessments involve hundreds of measurements of chemical exposures, neighborhood stressors, and early health indicators at the cellular level. With input from participants in studies of pregnancy and child health, this project will develop ethical and practical methods for reporting back personalized results in large studies with multiple types of data, offering reports that are meaningful and not overwhelming.

PI_NAMEs: BRODY, JULIA GREEN (contact);MORELLO-FROSCH, RACHEL ADELE;PADULA, AMY MICHELLE

PROJECT_TERMS: Back;Beneficence;Bioethics Consultants;Biological;Biological Markers;Biological Monitoring;California;Cells;Cellular Phone;Chemical Exposure;Chemicals;Child;Child Health;Chronic Disease;Clinical;cohort;Cohort Studies;Communication;Communities;Community Actions;Complex;Computers;Consensus;Data;design;Development;digital;digital tool;Discipline;Educational workshop;Engineering;Environmental Health;Environmental Risk Factor;environmental stressor;Equity;Ethical Issues;Ethics;experience;Family;follow-up;Fostering;Foundations;Genetic;Geography;Graph;Health;health assessment;Health behavior;health literacy;Health protection;Human;Illinois;Individual;innovation;Interview;Joints;Justice;Knowledge;late life;Learning;Length;Life Cycle Stages;Measurement;Measures;Medicine;Methods;multiple data types;Neighborhoods;non-genetic;online resource;Outcome;Outcome Assessment;Parents;Participant;patient engagement;Patient Self-Report;Persons;Positioning Attribute;Pregnancy;pregnancy health;prevent;Printing;Randomized;recruit;Reporting;Research;Research Personnel;Resources;response;San Francisco;satisfaction;Science;social;Social Environment;social factors;social media;social networking website;social stressor;Social support;Source;stressor;support tools;Surveys;Techniques;telomere;Testing;theories;Trust;trustworthiness;Uncertainty;United States National Academy of Sciences;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: From the Cell to the Street: Personalized Report-Back in Large Cohort Studies with Multi-Level Measurements


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: CAMBRIDGE HEALTH ALLIANCE

PHR: Project Narrative Critical self-judgment is a common phenomenon underlying a wide range of psychological disorders. The proposed project aims to investigate the neural mechanism of critical self- judgment by analyzing MRI and questionnaire data collected from 5 previous studies that all included mindfulness or compassion based interventions for various psychological symptoms, e.g., depression, anxiety, stress and chronic pain. Knowledge from this study will inform clinical practice to target critical self-judgment as an underlying common root for a wide range of psychological disorders.

PI_NAMEs: JOSS, DIANE  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: addiction;Amygdaloid structure;Anxiety;Area;Behavior Therapy;Brain;Characteristics;Child Abuse and Neglect;chronic pain;clinical application;clinical practice;Compassion;Data;Data Analyses;Development;Diagnostic;Dorsal;Eating Disorders;Effectiveness;Etiology;Frequencies;Functional Magnetic Resonance Imaging;Future;Hippocampus;Inferior frontal gyrus;innovation;insight;interest;Intervention;Judgment;Knowledge;Laboratories;Left;Magnetic Resonance Imaging;Measures;Medial;Mental Depression;Mental disorders;Middle Inferior Frontal Convolution;mindfulness;Modeling;negative affect;Negative Valence;neural;neural circuit;neuroimaging;neuromechanism;patient population;perceived stress;Personality Disorders;post intervention;post-traumatic stress;Prefrontal Cortex;Process;Production;Psychiatric Diagnosis;psychologic;psychological symptom;psychological trauma;Psychopathology;Psychotherapy;Questionnaires;Research;Research Domain Criteria;Research Proposals;Rest;Risk Factors;rumination;Self Perception;self-compassion;Self-Examination;Series;Severities;Speech;Stress;System;Testing;therapeutic target;Time;trait;Trauma

PROJECT_TITLE: Neural mechanism of critical self-judgment as a trans-diagnostic therapeutic target: a secondary data analysis study from the RDoC perspective

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Pediatric;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This project aims to promote improved mental health outcomes for young adults by combining electronic health records with psychiatric and cognitive dimensional measures to predict risk for, and course of, psychopathology. It will enroll a group of 10,000 individuals, ages 18-20, who will complete the brief web-based battery every six months for two years. The artificial intelligence models developed from combining psychiatric and cognitive dimensions with health records will allow health systems to conduct earlier mental health screening and link interventions to illness phase in the young adults most likely to benefit from them.

PI_NAMEs: DOYLE, ALYSA E;PERLIS, ROY H. (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: 20 year old;Academic Medical Centers;Address;Adolescence;Adolescent and Young Adult;Age;aged;artificial intelligence model;Behavior;Caring;Clinical;Clinical assessments;Clinical Data;clinical predictors;Code;Cognition;Cognitive;cognitive function;cognitive task;cohort;Communities;Consensus;cost;Data;Development;Diagnosis;Diagnostic;Dimensions;Early identification;Early Intervention;Economics;Education;Electronic Health Record;Elements;Employment;Enrollment;Equipment and supply inventories;evidence base;Evolution;explainable machine learning;falls;functional outcomes;General Population;Goals;health record;Health system;Healthcare Systems;improved;Individual;Intervention;Legal system;lens;Link;Literature;machine learning method;Maps;Measures;Mental disorders;Mental Health;Methods;Modeling;Natural Language Processing;Neurocognitive;neurocognitive test;neurodevelopment;neuropsychiatry;Neurosciences;novel;Online Systems;Outcome;Patient Self-Report;Patients;Performance;Phase;Phenotype;Population Heterogeneity;predictive modeling;predictive tools;prospective;psychiatric symptom;Psychopathology;psychosocial;Public Health;remote delivery;Reporting;Research Domain Criteria;Research Personnel;Resources;risk prediction;risk stratification;screening;Secure;Staging;substance use;Surgeon;Symptoms;Teenagers;Testing;Time;trait;Translating;Translations;Variant;virtual;Work;young adult;Youth

PROJECT_TITLE: JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The clinical diagnosis of Parkinson disease (PD) and multiple system atrophy (MSA) can be challenging, especially at early disease stages. This project aims to develop two compensatory blood-based biomarker assays, which will likely establish the foundation leading to inexpensive, accurate, and clinically routine tests that improves PD and MSA diagnosis accuracy and/or enhances disease progression monitoring.

PI_NAMEs: SHI, MIN  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 2',3'-Cyclic-Nucleotide Phosphodiesterases;Address;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Astrocytes;Binding;Biochemical Markers;Biological Assay;Biological Markers;Biopsy Specimen;Blood;Blood Tests;blood-based biomarker;blood-brain barrier crossing;Body Fluids;Brain;brain based;brain cell;candidate marker;cell type;Central Nervous System;Cerebrospinal Fluid;Characteristics;Clinical;Clinical assessments;clinical diagnosis;clinical practice;Clinical Trials;cohort;Complex;Development;Diagnosis;diagnostic accuracy;Differential Diagnosis;Disease;disease diagnosis;Disease Marker;Disease Progression;disorder control;experimental study;extracellular vesicles;Flow Cytometry;Foundations;Future;GLAST Protein;illness length;improved;in vivo;indexing;Individual;intercellular communication;International;Lewy Bodies;Measurement;Measures;Medical center;Membrane;Merozoite Surface Protein 1;Methodology;Monitor;Movement Disorders;Multiple System Atrophy;Neural Cell Adhesion Molecule L1;Neurodegenerative Disorders;neuroimaging;Neurons;Oligodendroglia;Parkinson Disease;Parkinsonian Disorders;Participant;Pathologic;Pathology;Patients;Performance;Pharmaceutical Preparations;Pilot Projects;Plasma;Play;protein biomarkers;Proteins;prototype;Rapid screening;rapid test;recruit;Reporting;Reproducibility;Role;Sampling;Screening procedure;Sensitivity and Specificity;Serum;Severity of illness;Societies;Source;Specificity;Surface;Symptoms;System;tau Proteins;Technology;Testing;Time;Validation;Vesicle

PROJECT_TITLE: Development of blood assays for multiple system atrophy and Parkinson disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Maternal Health;Mental Health;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Social Determinants of Health;Suicide;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Intimate partner violence (IPV) is common, with over 7% of U.S. women reporting physical or sexual violence, and/or stalking in the past year. Over half of women experiencing IPV are victimized multiple times over multiple years, therefore meeting the definition of a chronic condition. This proposal seeks to characterize the impact of state law on rates of IPV and IPV related health outcomes.

PI_NAMEs: DALTON, VANESSA K. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;access restrictions;Address;Affect;Age;aged;aging population;Anxiety;Birth;Black American;Cause of Death;Cessation of life;Chronic;comparative;completed suicide;Conflict (Psychology);Constitution;Contraceptive methods;court;Crime;Data;Decision Making;Ethnic Origin;Ethnic Population;Event;experience;firearm access;Firearms;Future;gun violence;Guns;Health;health disparity;health service use;Health Services;Healthcare;Heterogeneity;Homicide;Income;Individual;Injury;Interruption;intimate partner violence;Laws;Legal Abortion;Low Birth Weight Infant;Low income;Maternal Health;Medicaid;meetings;Mental Depression;Mental Health;Monitor;Morbidity - disease rate;mortality;Native American population;Natural experiment;neighborhood disadvantage;New York;Not Hispanic or Latino;Outcome;perpetrators;Persons;physical conditioning;Policies;Population;Post-Traumatic Stress Disorders;Pregnancy;Pregnancy loss;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;pressure;Prevalence;psychological violence;Quasi-experiment;Race;racial population;Regulation;Reporting;reproductive;reproductive coercion;Reproductive Health;Reproductive Health Services;Rifles;Risk;Risk Assessment;Risk Reduction;Series;Services;sexual violence;Subgroup;suicidal;Suicide;Supreme Court Decisions;Surveys;System;Teenagers;Testing;Time;Unwanted pregnancy;Variant;Victimization;Violence;violence victimization;violent relationship;White Women;Woman;Work

PROJECT_TITLE: Examining the impact of state laws on intimate partner violence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurosciences;Pediatric;Rare Diseases;Usher Syndrome

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Severe to profound hearing loss, largely attributable to injury to the sensory hair cells, affects 1 in 1,000 newborns, and 60% of people older than 70 years, and has multiple causes, genetic, environmentally induced, and age-related. The mechanisms of hair cell damage and death are in most cases not well understood and the work will address these mechanisms in two ways: firstly, by studying mouse mutants that have human equivalents such as TMC1, which, with over 50 mutations, is one of the most common causes of genetic hearing loss; secondly, by investigating mechanisms and reversibility of transduction loss in genetic deafness and the connection to hair cell apoptosis.

PI_NAMEs: FETTIPLACE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustics;Acute;Address;Affect;age related;Apical;Apoptosis;Auditory;biophysical properties;Biophysics;blebbistatin;Calcium;Calcium and Integrin Binding Protein 2;Cell Death;cell injury;Cells;cellular transduction;Cochlea;Complex;Consensus;Coupling;Cryoelectron Microscopy;deaf;deafness;Electrophysiology (science);Environment;experimental study;Future;Generations;Genetic;genetic deafness;Genetic Techniques;Goals;Grant;Hair;Hair Cells;hearing impairment;hereditary hearing loss;Human;Human Genetics;Image;Injury;Inner Hair Cells;insight;Interferometry;Ion Channel;Ions;Kinocilium;Lasers;Link;Lipids;Location;Measures;Mechanics;Membrane;Missense Mutation;Molecular;Motion;Movement;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Newborn Infant;non-muscle myosin;Older Population;Pathway interactions;PCDH15 gene;Permeability;postnatal;predictive modeling;Process;programs;Property;Protein Isoforms;Proteins;rat Pres protein;Reporting;response;Role;Route;Sensory Hair;Serine;Side;Site;Stereocilium;Stimulus;Structure;Surface;Tamoxifen;Testing;Time;tongue papilla;Transducers;Transmembrane Domain;transmission process;Vestibular Hair Cells;Work

PROJECT_TITLE: Intracellular Calcium in Hair Cells

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative A novel platform will be studied for therapeutic nucleic acid aptamer discovery and delivery. Its success will lead to a paradigm shift in the development of therapeutic nucleic acids for the treatment of various human diseases such as immune disorders.

PI_NAMEs: WANG, YONG  (contact);XIONG, NA

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: 3-Dimensional;Affinity;Animal Model;Antibodies;Anticoagulation;aptamer;Area;Binding;bioimaging;Biological Process;Biosensing Techniques;Biotechnology;cancer therapy;Cells;Charge;Chemicals;clinical diagnosis;Consumption;Convection;cost;cross reactivity;cytokine;Data;density;design;Development;Diffusion;Disease;Dissociation;Drug Delivery Systems;Drug Metabolic Detoxication;effectiveness evaluation;Environment;Failure;fighting;Foundations;gene therapy;Hour;human disease;Hydrogels;IL17 gene;Image;Immobilization;Immune System Diseases;in vivo;Inflammation;Inflammatory;innovation;instrument;Isoelectric Point;Lead;Libraries;Ligands;Mediating;Methods;Modeling;Molecular;Molecular Conformation;Nature;Needles;novel;nucleic acid-based therapeutics;Nucleic Acids;Pathway interactions;Pharmaceutical Preparations;Porosity;pre-clinical;pressure;Process;Proteins;Psoriasis;Regenerative Medicine;Research Activity;Running;Sequence Homology;Specificity;stem;Structure;success;Technology;technology platform;Therapeutic;Therapeutic Agents;therapeutic development;Therapeutic Effect;Therapeutic Studies;Time;virtual;Work

PROJECT_TITLE: Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The MIDAS network aims to advance science to improve global preparedness and response against infectious disease threats by supporting the infectious disease modeling community through research, training, promotion, and service. The MIDAS Coordination Center will support these important efforts by gathering resources necessary for infectious disease modeling research; harmonizing important datasets; fostering community-based activities; training infectious disease researchers; conducting coordination and outreach activities; and conducting novel research into the evaluation of infectious disease models. These efforts will build a stronger research community and advance the state of the science of infectious disease modeling.

PI_NAMEs: HOCHHEISER, HARRY S (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Archives;Catalogs;Characteristics;Clinical Data;Collection;Communicable Diseases;Communities;community organizations;community research;comparative;Computer software;COVID-19;COVID-19 pandemic;Data;Data Collection;data curation;data format;data resource;Data Set;Development;diverse data;Doctor of Philosophy;Education;education resources;Educational Activities;Educational Materials;Educational workshop;Ensure;epidemiological model;Evaluation;Event;Exercise;experience;Familiarity;Financial Support;flu;Fostering;Foundations;Funding;Goals;Government;Growth;improved;Individual;Infectious Agent;infectious disease model;Infectious disease threat;interest;Interest Group;interoperability;Latin American;Maps;Maryland;mathematical model;meetings;member;Metadata;model design;model development;Modeling;Monkeypox;next generation;novel;Online Systems;open data;outreach;Phase;Play;Process;Public Health;Public Health Schools;Readiness;Reproducibility;Research;Research Personnel;research study;Resources;response;Role;Science;Series;Services;special interest group;Standardization;Students;symposium;Taxonomy;Techniques;tool;Training;Training Activity;Training Programs;tutoring;Universities;Virginia;web site;webinar;Work;working group

PROJECT_TITLE: MIDAS Coordination Center - Year 6-10

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 BBCB-G (MD)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This proposal aims to create a series of deep learning (DL)-based pipelines for generating synthetic data points from chest radiographs for medical dataset augmentation and improved fairness in pathology detection. By leveraging generative modeling and Denoising Diffusion Probabilistic Models (DDPMs), this research has the potential to improve the accuracy and fairness of pathology detection in chest radiographs for underserved populations.

PI_NAMEs: ERICKSON, BRADLEY J.;KHOSRAVI, BARDIA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Adoption;African American population;Age;age related;Algorithms;Applications Grants;Architecture;Artificial Intelligence;artificial intelligence model;Body part;care outcomes;caucasian American;Cessation of life;Chest;Clinical Data;computing resources;Data;Data Set;Death Rate;deep learning;deep learning model;denoising;Detection;Diagnosis;diagnostic algorithm;Diffusion;Disparity;diverse data;Engineering;Ensure;ethnic minority population;experience;generative adversarial network;generative models;Genetic;Goals;Health;health equity;health equity promotion;Health Status;Healthcare;Image;image reconstruction;improved;Infant Mortality;Institution;Life Expectancy;Medical;Medical Imaging;Methods;Minority;Minority Groups;minority patient;Modality;Modeling;Noise;open source;outcome disparities;Pathology;Patients;Performance;Persons;Pleural effusion disorder;Pneumonia;Pneumothorax;Positioning Attribute;prognostic algorithm;Property;Race;racial minority;racial minority population;racial population;Research;Research Personnel;Research Project Grants;Scheme;Series;sex;Societies;Specific qualifier value;Statistical Models;Subgroup;synthetic data;Testing;Thoracic Radiography;tool;Training;training data;Underserved Population;United States;Validation;Weight;Work

PROJECT_TITLE: Investigating the Effect of Synthetic Medical Images on Fairness in Medical Deep Learning Research

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DETROIT

ORG_DEPT: BIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project narrative Immunity is important not only for fighting infection but also many human diseases, such as cancer. The Hippo pathway is well-known for its anti-cancer role, but recent discoveries indicate this pathway is crucial for immunity. This study focuses on dissecting contribution of the Hippo kinases in immunity, which will inform development of new therapeutics to treat infection and other human diseases.

PI_NAMEs: LEE, PEI-CHUNG  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Affect;Animal Model;anti-cancer;antibody detection;Apoptosis;Apoptotic;Autoimmune Diseases;Bacteria;Bacterial Infections;Biochemical;Biological Assay;Biological Process;Biological Response Modifiers;CASP1 gene;Caspase;Cell Death;Cell Line;Cell model;Cell Proliferation;cell type;Cells;Classical Complement Pathway;Communication;Complement;Complement 1q;Complement 2;controlled release;cytokine;Data;Defense Mechanisms;Development;Disease;Exhibits;experience;experimental study;Exposure to;fighting;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Health;Host Defense;Human;human disease;human pathogen;Immune;Immune response;Immunity;Immunocompromised Host;In Vitro;in vitro Assay;Individual;Infection;Inflammasome;Inflammatory;Inflammatory Response;innovation;insight;Knock-out;knockout gene;LATS1 gene;Lead;Legionella pneumophila;Legionnaires' Disease;Length;Link;loss of function mutation;Lupus;Macrophage;Malignant Neoplasms;Mammals;Mediating;Methods;Modeling;Molecular;N-terminal;Natural Immunity;novel;novel therapeutics;organ growth;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pattern;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Predisposition;Production;protein expression;Proteins;Proteome;Proteomics;recurrent infection;Regulation;Research;Resources;Role;Scaffolding Protein;sensor;Signal Pathway;Signal Transduction;Specificity;Substrate Specificity;Techniques;Therapeutic;tissue regeneration;Tissues;transcriptome;tumor;Validation;Variant;Virulence Factors;Virulent;Work;Yeasts

PROJECT_TITLE: Regulation of Innate Immunity by the Hippo Kinases

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Violence Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed work tests whether racially targeted police stops correspond with suicide-related outcomes among Black youth in a longitudinal, ecological manner. Our project may assist in elucidating the extent to which there exists a causal link between racialized hyper-surveillance and suicide mortality in a highly vulnerable population.

PI_NAMEs: SINGH, PARVATI  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Accident and Emergency department;Address;Age;age group;aged;Amendment;anxiety symptoms;Behavior monitoring;Black American;black men;Black Populations;Black race;Cause of Death;Code;Communities;Constitution;County;court;Crime;Data;data format;Data Set;Databases;depressive symptoms;Diagnosis;Discrimination;econometrics;Elements;Emergency department visit;Ethnic Origin;Ethnic Population;Exhibits;Feeling suicidal;Freedom;Individual;Inpatients;interest;Judgment;Law Enforcement;Legal;Link;Mental Health;Methods;mortality statistics;Movement;Natural experiment;New York;New York City;Outcome;Pattern;Police;Policies;Population;Prevention;psychological distress;public database;Race;racial bias;racial disparity;racial population;racism;Reporting;Research;Rest;Self-Injurious Behavior;Series;sex;sex variable;social determinants;spatiotemporal;suicidal morbidity;suicidal risk;Suicide;suicide mortality;Suicide prevention;suicide rate;Testing;Time;Time Series Analysis;trauma symptom;trend;United States National Center for Health Statistics;US State;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Hyper-surveillance and suicides among Black youth in the U.S.

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Project Summary/Abstract Metabolic dysfunction occurs decades prior to the development of Alzheimer’s disease (AD), and alterations in mitochondrial complex-I (MC-1) may be the culprit. The emergence of novel imaging tools allows quantitative and non-invasive assessment of both the availability and metabolic function of MC-1, enabling mechanistic understandings of mitochondrial dysfunction, revolutionizing how we monitor metabolic health in vivo, and paving the way for therapeutic development targeting MC-1 and mitochondrial metabolism. In this exploratory study, we will evaluate the feasibility of two novel scanning techniques in murine models of AD to 1) image the availability of MC-1 using [18F]BCPP-EF PET and 2) assess the MC-1 metabolic function in real time using hyperpolarized MR spectroscopy to observe the metabolic conversion of [2-13C]pyruvate to [5-13C]glutamate, a process occurring in mitochondria, serving as a readout of MC-1 metabolic function.

PI_NAMEs: WEY, HSIAO-YING ;YEN, YI-FEN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Affect;Affinity;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Disease Models;Animals;Anti-diabetic Drugs;Binding;Biochemical Reaction;biological adaptation to stress;Brain;Brain region;brain volume;C57BL/6 Mouse;Cells;Clinical Research;Clinical Trials;comorbidity;comparison group;Complex;Contrast Media;Corpus striatum structure;Data;density;Development;diabetic;Disease;Disease Progression;dosage;Dose;Early Onset Alzheimer Disease;Electron Transport;Enzymes;Exercise;Failure;fluorodeoxyglucose positron emission tomography;Functional disorder;Future;gender difference;Glucose;glucose uptake;Glutamates;Glycolysis;Goals;Health;healthy aging;Human;Image;Imaging Device;Imaging Techniques;Immunohistochemistry;improved;in vivo;inhibitor;Injections;Inner mitochondrial membrane;Investigation;Magnetic Resonance Spectroscopy;Measures;Melanocortin 1 Receptor;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metformin;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;mitochondrial therapeutics;molecular imaging;Monitor;mouse model;Multienzyme Complexes;Mus;Natural regeneration;Nerve Degeneration;neurofibrillary tangle formation;Neuroglia;neuron loss;Neurons;neuroprotection;non-invasive imaging;Normal Range;novel;novel strategies;novel therapeutics;old mice;Oxidative Phosphorylation;Oxidative Stress;Pathogenicity;Pathologic;Patients;pharmacologic;Phosphorylation;Play;Positron-Emission Tomography;Process;Production;Protons;Pyruvate;Rattus;Recycling;Research;Respiratory Chain;response;Role;Rotenone;Scanning;secondary endpoint;Senile Plaques;Standardization;Stress;success;Surrogate Markers;Symptoms;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Techniques;therapeutic development;time use;Tracer;treatment strategy;uptake;Wild Type Mouse

PROJECT_TITLE: Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease Model

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Lupus

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inefficient clearance of apoptotic cells, termed efferocytosis. Lipid metabolism is linked to the efferocytosis function of macrophages, but the mechanism by which macrophages regulate lipid metabolism for efferocytosis is unknown. In this project, we will define how the quantity and composition of lipid droplets in macrophage subsets affect efferocytosis and determine if they can be manipulated to shift macrophage function for the treatment of SLE.

PI_NAMEs: SON, MYOUNGSUN  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Affect;Anabolism;Anti-Inflammatory Agents;Apoptotic;Arachidonic Acids;Autoimmune Diseases;Biochemical;Biogenesis;Biological Assay;Bone Marrow;C1q deficiency;Catabolism;Cell Physiology;Cells;Complement 1q;complement system;Confocal Microscopy;Docosahexaenoic Acids;Enzymes;Etiology;Exhibits;experimental study;Exposure to;Goals;high resolution imaging;Histologic;HMGB1 gene;Human;Hydrolysis;Immune;Immune system;Immune System Diseases;Immune Tolerance;Immunosuppressive Agents;Impairment;Inflammatory;inhibitor;Interferon Type II;Interleukin-4;Link;lipid metabolism;lipidomics;Lipids;Lipopolysaccharides;Lupus;lymph nodes;Macrophage;Mass Spectrum Analysis;Measures;Membrane;Metabolic;Metabolic Diseases;Molecular;monocyte;new therapeutic target;Nonesterified Fatty Acids;Oleic Acids;Organelles;particle;Pathologic;Pathway interactions;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;Polyunsaturated Fatty Acids;protein complex;Protein Tyrosine Kinase;Proteins;Proteomics;receptor;Research;Resolution;response;Role;Saturated Fatty Acids;Serum;Signaling Molecule;Systemic Lupus Erythematosus;Testing;Therapeutic;therapeutic target;Toxic effect;Triglycerides;Work

PROJECT_TITLE: Role of Lipid Droplets in Macrophages and their Consequences in Lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE CDC and SAMHSA data indicate that in 2021 there were about 500,000 new U.S. cocaine users aged 12 and older and that cocaine accounted for about 1 in every 4 drug overdose-related deaths. Development of novel therapies to address the challenge of new and on-going cocaine use depends on insights into the underlying biological changes within the brain of affected individuals, but prior research has focused overwhelmingly on how cocaine affects activity of neurons. This proposal explores new evidence that cocaine changes activity of astrocytes that are predicted to influence on-going cocaine use and relapse to use after abstinence.

PI_NAMEs: ORTINSKI, PAVEL IVANOVICH (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;Action Potentials;Address;Affect;aged;Animals;antagonist;Astrocytes;Attenuated;attenuation;Behavior;Binding;Biological;Brain;cell type;Cells;Cessation of life;Cocaine;cocaine cue;cocaine exposure;cocaine relapse;cocaine related behaviors;cocaine seeking;cocaine self-administration;cocaine use;Cocaine Users;Coupling;Cues;cytokine;Cytoskeleton;Data;defined contribution;Development;Dopamine;Dose;Electrophysiology (science);Endoplasmic Reticulum;Evaluation;Event;Exposure to;Extinction;extracellular;extracellular vesicles;fluorocitrate;Foundations;Frequencies;Generations;Homeostasis;Human;Image;Individual;insight;Ions;knock-down;Link;Literature;Measures;Mediating;Mediator;Membrane;Messenger RNA;Metabolic;Microinjections;Modeling;Molecular;Morphology;Neurodevelopmental Disorder;Neuroglia;Neurons;neurotransmission;neurotransmitter release;novel;novel therapeutics;Nucleus Accumbens;Outcome;Output;Overdose;Permeability;Pharmaceutical Preparations;pharmacologic;Potassium Channel;pre-clinical;Process;Production;Proteins;Publishing;Rattus;Regulation;Reporting;Research;response;Role;Self Administration;sensor;Shapes;shared attention;Signal Transduction;Slice;small hairpin RNA;Source;substance use;Synapses;Techniques;Toxin;Training;Trauma;United States Substance Abuse and Mental Health Services Administration;Viral;Virus;voltage;voltage gated channel;Voltage-Gated Potassium Channel

PROJECT_TITLE: Regulation of cocaine use by astrocyte voltage-gated channels

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: EL PASO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

ORG_STATE: TX

PHR: Project narrative  GABAergic neurons, the most common inhibitory neurons present in the human brain, were found to be dysfunction in Alzheimer’s disease. The molecular mechanism about the deregulation of GABAergic synapse function is largely unknown in Alzheimer’s disease. The present study is designed to understand the molecular mechanism behind the GABAergic synapse dysfunction in Alzheimer’s disease.

PI_NAMEs: KUMAR, SUBODH  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Age;Alzheimer's Disease;Amyloid beta-Protein;Behavioral;Biochemical;Brain;Cognitive;design;Development;Disease Progression;Functional disorder;Human;Impaired cognition;inhibitory neuron;Intercellular Junctions;Knockout Mice;Link;MicroRNAs;Molecular;nervous system development;neuronal growth;Neurons;Outcome Study;Pathogenesis;Pathology;Property;Proteins;Role;Signal Transduction;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Synaptosomes;tau Proteins;tau-1;Testing;Therapeutic;Toxic effect;Transgenic Organisms;Wild Type Mouse

PROJECT_TITLE: Synaptosomal MicroRNAs, Synaptic Damage and Cognitive Decline in Alzheimer's Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PHR: Project Narrative Although many studies have described race/ethnic-based discrepancies in suspensions and expulsions for children of color relative to White children, little is known about how teachers evaluate children’s behaviors that serve as the basis for these disciplinary decisions, especially at the preschool level. This study addresses this limitation by examining whether children of color with similar demographics and comparable levels of social-emotional regulation as White children receive harsher behavioral assessments. It also examines whether teacher-child racial/ethnic match influence children’s behavioral ratings.

PI_NAMEs: LE, VI-NHUAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Achievement;Address;African American student;Age;Bachelor's Degree;Behavior;Behavior assessment;Behavioral;Bite;Black race;Certification;Child;Child Behavior;Child Care;Child Development;children of color;Color;Communities;Decision Making;demographics;Development;Educational process of instructing;elementary school;emotion regulation;Emotional;Equity;ethnic difference;Ethnic Origin;expectation;experimental study;externalizing behavior;Funding;Future;Hispanic;Impairment;Incidence;Income;informant;Judgment;K-12 Education;large scale data;Licensure;Literature;Methodology;Nursery Schools;Outcome;Perception;Problem behavior;programs;qualified teachers;Race;racial difference;Reporting;Research;Sample Size;School Teachers;Schools;social;Socioeconomic Factors;Students;Suspensions;teacher;Time

PROJECT_TITLE: Examining Potential Biases in Preschool Teachers’ Behavioral Assessments of Children of Color

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative A major obstacle to advancing precision psychiatry is the lack of individual-level measures suited to clinical decisions. We will optimize and validate a clinical signature measuring a cognitive phenotype linked to treatment non-response and disability in depression, enabling individualized prediction of risk and treatment selection.

PI_NAMEs: AJILORE, OLUSOLA A.;MA, JUN ;WILLIAMS, LEANNE  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acceleration;Adult;Aftercare;anti-depressive agents;Area;Assessment tool;Behavior;Behavior assessment;Behavior Control;behavior measurement;Behavior Therapy;Behavioral;Biometry;career;Cellular Phone;Chicago;Clinical;clinical decision-making;clinical practice;clinical predictors;clinical prognostic;Clinical Treatment;Clinical Trials;Cognition;Cognitive;cognitive control;Cognitive deficits;cohort;Collaborations;Complement;computerized;Country;Data;Data Element;Data Set;Development;digital;digital phenotyping;disability;Disability outcome;Disease remission;Double-Blind Method;Ethics;Ethnic Origin;follow-up;Future;Grain;Guanfacine;Image;Impaired cognition;improved;Individual;individual variation;individualized medicine;innovation;interest;Life Experience;Link;Lived experience;Machine Learning;Major Depressive Disorder;Measurement;Measures;Mental Depression;Mental Health;Modeling;multidisciplinary;multimodal data;neural;neural circuit;neural correlate;neuroimaging;neuromechanism;novel;Outcome;outcome prediction;Participant;participant retention;Patient Outcomes Assessments;Patient Recruitments;Pattern;Performance;personalized medicine;personalized risk prediction;Pharmacotherapy;Phenotype;Placebos;Population Heterogeneity;predicting response;Prediction of Response to Therapy;predictive modeling;primary outcome;prognostic;prospective;Prospective cohort;Psychiatry;Publishing;Quality of life;Race;Randomized;randomized trial;randomized, clinical trials;recruit;remote administration;Research;Research Domain Criteria;Research Personnel;Research Project Grants;response;risk selection;Sampling;Selection for Treatments;Sertraline;Severities;Site;smartphone application;socioeconomics;Statistical Models;Stratification;Structure;Symptoms;synergism;Technology;Translating;Translations;treatment arm;Treatment outcome;treatment response;Underrepresented Populations;Validation;Work

PROJECT_TITLE: ACE-D: Accelerating Cognition-guided signatures to Enhance translation in Depression


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Genetic and epidemiologic evidence linking underlying immune dysfunction and autoimmune conditions (AIDs) with Parkinson’s disease risk and worse outcomes. We hypothesize that inflammatory mechanisms contribute to both PD and autoimmune diseases, and certain candidate therapies approved to target immune processes in AIDs are also effective in mitigating PD risk and phenoconversion. Here, we will leverage the well- characterized effects of genetic variation influencing the expression or function of individual therapeutic targets (summarized using polygenic scores) as instruments to help to understand the downstream effects of AID treatment on PD risk and conversion from prodromal to diagnosed PD. .

PI_NAMEs: FITZGERALD, KATHRYN C. (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Affect;Alzheimer's disease risk;American;Autoimmune Diseases;Binding;biobank;Bioinformatics;bioinformatics pipeline;Biological;Birth;burden of illness;cardiovascular effects;Care given by nurses;cell type;Cells;Cessation of life;Chronic;Clinical;cost;cost effective;Data;design;Development;Diagnosis;differential expression;disability;disability burden;Disease;disease diagnosis;Disease Outcome;Disease Progression;disorder risk;Drug Exposure;Drug Targeting;Elements;Enhancers;Epidemiology;Epigenetic Process;Etiology;Exclusion;experience;Exposure to;follow-up;Foundations;Future;Genes;Genetic;Genetic Variation;Goals;high risk;Hospitalization;Immune;immune activation;Immune System Diseases;Immune Targeting;Immunologic Factors;Immunotherapy;improved;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;innovation;insight;instrument;Link;Medical Care Costs;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic;Neurons;new therapeutic target;novel;novel strategies;nursing skill;Onset of illness;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Play;Population;prevent;Prevention strategy;Preventive measure;Process;promoter;Proteins;Psoriasis;Risk;Risk Factors;Risk Reduction;risk stratification;Role;Severities;Severity of illness;Specific qualifier value;Symptoms;targeted treatment;Testing;Therapeutic Agents;therapeutic target;therapy outcome;transcription factor;Variant;Work

PROJECT_TITLE: Repurposing Existing Therapies for Parkinson's Disease Risk and Phenoconversion


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing and testing clinical decision support in intensive care units for timely identification of patients suitable for activity interventions. We expect study results will impact the field by developing a pragmatic way of accelerating the concurrent use of patient data with guideline recommendations at the point of care to support ICU clinicians in delivering evidence-based care, decrease the duration of bedrest, and reduce hospital-acquired functional decline. Thus, the proposed research is relevant to the part of AHRQ's mission that pertains to making healthcare safer, higher quality, and evidence-based.

PI_NAMEs: DUNN LOPEZ, KAREN ;KRUPP, ANNA  (contact)

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

PROJECT_TITLE: Improving Identification and Coordination of Mobility Interventions in the ICU Using Clinical Decision Support

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: In aging, MDD is linked to systemic inflammation, cognitive deficits and treatment-resistance, with women highly susceptible. In an animal model, we will test the impact of sex and age on hypobaric hypoxia-induced depressive, anxiety and cognitive symptoms. Since rates of antidepressant treatment-resistance increase with aging, the impact of age and sex will be addressed on the antidepressant-like efficacy of SSRIs and the bioenergetic com- pound cyclocreatine under conditions of chronic hypobaric hypoxia.

PI_NAMEs: KANEKAR, SHAMI  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adult;Adult women;Affect;Age;age effect;aged;Aging;Air;Altitude;Anhedonia;Animal Model;anti-depressive agents;Anxiety;anxiety symptoms;anxiety-like behavior;Behavior;Behavioral;Bioenergetics;Biological;Biological Markers;Brain;Brain-Derived Neurotrophic Factor;Chronic;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Cognitive Therapy;Creatine;cytokine;Depressed mood;depressive symptoms;Desipramine;Development;Diet;disorder risk;Disproportionately impacts women;Environmental Risk Factor;Euthanasia;executive function;Exhibits;Exposure to;Female;Fluoxetine;Foundations;functional disability;Future;geriatric depression;Goals;Guidelines;hallmarks of aging;Health Status;high risk;Hippocampus;Housing;human old age (65+);Hypoxia;IL6 gene;Impaired cognition;Impairment;improved;Inflammation Mediators;Inflammatory;inflammatory modulation;Interleukin-1 beta;Interleukin-6;late life;Learning;Link;Major Depressive Disorder;male;Mediating;Memory;men;Mental Depression;Mental Health;Methods;Modeling;molecular marker;monoamine;negative affect;Neurobehavioral Manifestations;neurogenesis;neurotrophic factor;novel;novel therapeutics;older adult;older patient;Oxygen;Partial Pressure;Pathway interactions;Patients;Periodicity;Persons;Phenotype;Play;pleasure;Predisposition;Prevalence;Process;Rattus;residence;response;Risk;Risk Factors;Role;Sea;Selective Serotonin Reuptake Inhibitor;Serum;sex;sex as a biological variable;standard of care;Stimulus;Stress and Coping;systemic inflammatory response;Testing;Therapeutic;therapy resistant;TNF gene;translational model;Treatment Efficacy;treatment-resistant depression;Woman;young adult

PROJECT_TITLE: Sex-based study of chronic hypoxia-related vulnerability to depression: age effects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (95)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Remodeling of synaptic connections between neurons is considered a cellular basis of information storage in the brain. In this proposal, we will examine the regulation and functions of the master transcription factor CREB within synapses and in strengthening neuronal connections. The results will provide a deeper understanding of learning and memory in physiological conditions as well as insights into cognitive dysfunction in memory disorders.

PI_NAMEs: PAK, DANIEL T (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;Alzheimer's Disease;AMPA Receptors;Antibodies;Back;Binding;Binding Proteins;Biological Assay;Brain;Calcium;Cell Nucleus;Cells;Chemosensitization;Code;Communication;CREB1 gene;Cyclic AMP;Data;deletion analysis;Dendritic Spines;DNA Sequence;Electrophysiology (science);Environment;Epitope Mapping;Epitopes;Excitatory Synapse;experimental study;Fourier Analysis;Gene Expression;Generations;Genes;Genetic Transcription;Hippocampus;Impaired cognition;Information Storage;insight;knock-down;Knock-out;Learning;Long-Term Potentiation;Maintenance;Mass Spectrum Analysis;Mediating;member;Memory;Memory Disorders;Morphology;mutant;N-Methyl-D-Aspartate Receptors;neural;Neurodegenerative Disorders;neuronal survival;Neurons;novel;Nuclear;Ontology;Pathway interactions;Pattern;pharmacologic;Phase;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;programs;protein activation;protein distribution;protein function;Protein Isoforms;protein transport;Proteins;recruit;Regulation;Research;response;Response Elements;Role;Second Messenger Systems;Serine;Signal Pathway;Signal Transduction;Site;Slice;Specificity;Stimulus;superresolution microscopy;Synapses;Synaptic plasticity;Synaptic Potentials;Synaptic Transmission;Synaptosomes;Testing;Tissues;trafficking;transcription factor;Transcription Initiation;transcriptome sequencing;Translations;transmission process;Travel;Validation

PROJECT_TITLE: Regulation and functions of CREB in excitatory synapses of hippocampal neurons

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: OVERALL  Alzheimer’s disease and related dementias are a pressing challenge for our nation and disparately affect diverse populations in the Deep South. The UAB Alzheimer’s Disease Research Center (ADRC) will contribute to the fight against Alzheimer’s disease by accelerating AD research at UAB, across the Deep South, and nationally.

PI_NAMEs: ROBERSON, ERIK D (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Address;Affect;African American;Alabama;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Awareness;base;Biological Markers;Black American;Black race;brain tissue;career;Cerebrospinal Fluid;Chronic;Clinical;Clinical Trials;cohort;Collaborations;Communities;community based participatory research;comorbidity;Consultations;Data;data management;Data Set;data sharing;Deep South;Dementia;Development;Digital biomarker;Disease;Disparity;disparity elimination;Disparity population;DNA;education research;experience;experimental analysis;Experimental Designs;Faculty;fecal microbiome;fighting;Fostering;Funding;Future;Genetic;genetic analysis;Goals;Grant;Health;health disparity;Heart;Home;Human Resources;Image;imaging biomarker;Individual;Infrastructure;innovation;Liquid substance;Mentors;Nerve Degeneration;neuropathology;next generation;novel therapeutics;Office of Administrative Management;outcome disparities;outreach;pandemic disease;Participant;Peripheral Blood Mononuclear Cell;Physical activity;Plasma;Population;Population Heterogeneity;Program Development;programs;Race;Recording of previous events;recruit;repository;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;RNA;Sampling;Scholars Program;Scientist;Serum;Site;Skin Tissue;Sleep;social health determinants;success;symposium;tau Proteins;Training;Universities;Urine;Vascular Diseases;Vision;Visual impairment;Work

PROJECT_TITLE: UAB Alzheimer's Disease Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Welfare;Awareness;base;Communication;Communities;Data;data management;Deep South;Dementia;Development;Diagnosis;Disparity;education research;Ensure;Evaluation;Faculty Recruitment;Fostering;Funding;Goals;Grant;Human Resources;human subject;Institution;Lead;Leadership;meetings;Mission;Monitor;Newsletter;Occupational activity of managing finances;operation;organizational structure;outreach;Participant;Performance;Play;Policies;Process;programs;Progress Reports;recruit;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Role;Scanning;Scientific Inquiry;Secure;social media;sound;statistics;Strategic Planning;symposium;tool;United States National Institutes of Health;Universities;Vision;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: GELDMACHER, DAVID S (contact)

PROJECT_TERMS: Acceleration;actigraphy;Address;African American;Alabama;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Autopsy;Biolectric Impedance;Biological Markers;Black American;Black race;Blinded;Blood;Body Composition;Body mass index;Body measure procedure;Brain;Characteristics;circadian;Classification;Clinical;Clinical assessments;Clinical Data;clinical diagnosis;Clinical Management;Clinical Research;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Collection;Communities;community engagement;comorbidity;Consensus;Consent;cost;Data;Data Analyses;Data Collection;data format;data management;data quality;Data Set;data sharing;Deep South;Dementia;dementia risk;demographics;Development;Diabetes Mellitus;Diagnosis;Digital biomarker;Disparity;DNA;Doctor of Philosophy;Education;education research;Eligibility Determination;end of life;Enrollment;Ethnic Origin;Fostering;Frequencies;functional outcomes;functional status;Future;Gambling;genetic analysis;Genotype;Goals;health disparity;Image;Impaired cognition;Individual;innovation;Life;Life Cycle Stages;Life Style;Liquid substance;Magnetic Resonance Imaging;Measures;member;Metabolic;mild cognitive impairment;molecular imaging;Monitor;multidisciplinary;Nerve Degeneration;neuropathology;nutrition;Obesity;Office of Administrative Management;outreach;Participant;participant retention;patient engagement;Peripheral Blood Mononuclear Cell;Physical activity;physical inactivity;Physiological;Plasma;poor sleep;Population;Positron-Emission Tomography;Process;programs;Protocols documentation;Race;recruit;Research;Research Personnel;Resource-limited setting;Resources;RNA;Role;Sampling;Science;Senior Scientist;Serum;sex;Sleep;social health determinants;Specimen;stressor;structural imaging;symposium;tau Proteins;Testing;Thinness;training opportunity;Trust;Urine;Vascular Diseases;Visceral fat

PROJECT_TITLE: Clinical Core


PI_NAMEs: EDWARDS, LLOYD J (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Architecture;Autopsy;Awareness;Biological Markers;Biological Specimen Banks;Biometry;Brain;Clinical;clinical center;Clinical Sciences;cohort;Collaborations;Collection;Communities;Companions;Consent;Consultations;Custom;dashboard;Data;Data Analyses;Data Coordinating Center;data integration;data integrity;data management;data quality;Data Science;data sharing;database query;Deep South;design;Development;Diagnosis;Disparity;Ecosystem;Education;education research;Ensure;Equipment and supply inventories;Etiology;Event;experience;Experimental Designs;Eye;Faculty;Fostering;Funding;Funding Opportunities;Future;Genetic;Image;improved;Individual;Information Systems;insight;interest;Logistics;Manuscripts;Medical;medical specialties;member;Mentors;Mentorship;Methodology;Methods;migration;Modernization;Monitor;neuroimaging;Neuropsychology;operation;outreach;Participant;Patient Recruitments;Performance;Pilot Projects;Process;process improvement;programs;Protocols documentation;Publications;Pythons;quality assurance;Quality Control;Race;recruit;Registries;relational database;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Subjects;Research Support;Resources;Retrieval;Review Literature;Role;Scholarship;Science;Secure;Services;sex;Statistical Data Interpretation;Statistical Methods;tool;Training;training opportunity;Translational Research;trial readiness;Visit;Visualization software

PROJECT_TITLE: Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: CHKHEIDZE, RATI  (contact)

PROJECT_TERMS: Address;African American;African American population;Aliquot;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Autopsy;Biological Assay;Biological Markers;Biological Specimen Banks;Black American;Blood Vessels;Board Certification;Brain;brain tissue;Clinical;clinical center;clinical conference;cohort;Collaborations;Collection;Comprehension;Data;data integration;data management;Data Set;Databases;Deep South;Dementia;Detection;Development;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disparity;DNA;Education;effective therapy;Equipment and supply inventories;Family;Freezing;Funding;Goals;Grant;Home;Image;innovation;Investigation;Leadership;lectures;Liquid substance;Magnetic Resonance Imaging;Measures;Mentors;Mission;Modeling;Nerve Degeneration;neuropathology;operation;outreach;Participant;Pathology;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phase;Plasma;Play;Population;Population Heterogeneity;Positioning Attribute;Process;programs;Proteins;Protocols documentation;racial difference;recruit;Reporting;repository;Research;Research Personnel;RNA;Role;Sampling;Scholars Program;Serum;Skin;Skin Tissue;Source;Specimen;symposium;tau Proteins;Tissue Donations;Tissue Sample;Tissues;United States National Institutes of Health;Urine;Visit;Work

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: CLAY, OLIVIO J (contact)

PROJECT_TERMS: Address;Affect;African American;Aging;aging brain;Alabama;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Awareness;Black race;brain health;clay;Clinical;clinically relevant;Cognitive;cohort;Collaborations;Communities;community advisory board;community based participatory research;community engaged research;community engagement;Community Health;Community Health Education;Community Networks;Community Outreach;community partners;community partnership;community research;Consultations;Counseling;Data;data management;Data Set;Deep South;Dementia;dementia risk;design;Disparity;Economics;education research;Educational Curriculum;Educational process of instructing;effectiveness evaluation;Enrollment;equity, diversity, and inclusion;Event;experience;Familiarity;Family;follow-up;Fostering;Freezing;Future;Goals;Health;healthy aging;Image;Impaired cognition;Incidence;Individual;Inequity;interest;lectures;Link;Measures;Medical;meetings;member;Methodology;metropolitan;Mind;Minority;Mission;Modality;Modeling;Neighborhoods;news;Nurses;operation;outreach;Participant;participant enrollment;participant retention;Patients;Phase;programs;Provider;Publishing;Recording of previous events;recruit;recruitment science;Registries;Research;Research Design;Research Personnel;Resources;retention rate;rural counties;Schedule;Series;Services;social;social health determinants;Specialist;Training;training opportunity;Trust;Visit;Work;Workplace

PROJECT_TITLE: Outreach, Recruitment, and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: MCCONATHY, JONATHAN EDWARD (contact)

PROJECT_TERMS: 3-Dimensional;Affect;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Applications Grants;arterial spin labeling;Authorization documentation;Autopsy;Biological Markers;Black American;Blood Vessels;Brain;Brain region;brain volume;Cerebrospinal Fluid;Cerebrovascular Disorders;Classification;Clinical;Clinical assessments;clinical care;Clinical Management;cloud based;cloud storage;Cognition Disorders;cognitive change;cohort;Collaborations;Consensus;Cyclotrons;Data;data management;Data Set;Databases;Deep South;design;Diffusion Magnetic Resonance Imaging;Digital Imaging and Communications in Medicine;Discipline of Nuclear Medicine;Disparity;education research;Educational Activities;Etiology;Exposure to;Faculty;FDA approved;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Image;Image Analysis;imaging agent;imaging biomarker;imaging facilities;Impaired cognition;Individual;innovation;Institution;Link;Liquid substance;Magnetic Resonance Imaging;Measures;medical specialties;member;Molecular;Molecular Bank;molecular imaging;multimodality;Nerve Degeneration;neuroimaging;neuroimaging marker;neuroinflammation;Neurology;Neuronal Dysfunction;neuropathology;Neurosciences;Office of Administrative Management;Output;outreach;Participant;Performance;Perfusion;Phase;Population;Positron-Emission Tomography;Process;Prognosis;programs;racial disparity;Radiology Specialty;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Research Technics;Resources;Rest;Risk;Scanning;Scholars Program;searchable database;Secure;symposium;System;tau Proteins;Therapy trial;Time;Tracer;Training;Training Support;Underrepresented Populations;Vascular Diseases;web-accessible;White Matter Hyperintensity;Work

PROJECT_TITLE: Imaging Core


PI_NAMEs: NATELSON LOVE, MARISSA C (contact)

PROJECT_TERMS: Achievement;Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Experiments;Animal Model;Basic Science;Brain imaging;career;Clinical;clinical conference;Clinical Sciences;Collaborations;Communities;Competence;Consultations;data management;Data Set;data warehouse;Databases;Deep South;Dementia;Department chair;Development;Development Plans;Discipline;Disparity;doctoral student;Documentation;education research;Educational Curriculum;Educational workshop;Electronic Mail;Environment;Etiology;experience;Faculty;Future;Gifts;Goals;graduate student;Grant;Hand;Health Disparities Research;Hour;improved;Infrastructure;innovation;interest;Journals;Learning;Manuscripts;Measures;Memory;Mentors;Mentorship;Methodology;Mind;Minority;Mission;multidisciplinary;Nature;Nerve Degeneration;news;Newspapers;open source;Participant;Pathologic;Pathway interactions;Patients;Personal Communication;Positioning Attribute;Postdoctoral Fellow;pre-clinical;prevent;Publications;recruit;Reproducibility;Research;Research Personnel;Resources;Scholars Program;Scientist;Secure;skills;social media;Societies;Training;training opportunity;Training Support;Universities;user-friendly;virtual;Vision;Work;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Nutrition;Obesity;Physical Activity;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The ability to assess body composition and physical activity (PA) with wearable technology offers many benefits for people with DS such as completing measurements in a comfortable testing environment. Despite the potential benefits and convenience of wearable technology, the accuracy of devices for measuring body composition and PA needs to be established prior to widespread adoption and utilization in this special population. Accordingly, this proposal will address a primary scope of NOT-OD-21-092, which includes validating at-home diagnostic tools, including actigraphy and wearable technologies, in adults with DS.

PI_NAMEs: ESCO, MICHAEL ;NICKERSON, BRETT STEPHEN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Accelerometer;actigraphy;Adoption;Adult;Age Years;Agreement;Ankle;Anxiety;Area;Body Composition;Body fat;Body mass index;Body measure procedure;burden of illness;cardiovascular disorder risk;Clinical;Cross-Sectional Studies;design;Development;Devices;diagnostic tool;Down's Syndrome;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Early Intervention;Educational Intervention;Environment;exercise intervention;experience;Fatty acid glycerol esters;fitness;Gait abnormality;Galaxy;Hand;Health;Health Promotion;Home;improved;Individual;insight;Knowledge;Laboratories;Laboratory Research;Life;lifestyle intervention;Lower Extremity;Malignant Neoplasms;Measurement;Measures;Methods;Mission;mobile computing;Monitor;motion sensor;Movement;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;Parents;Patients;Pattern;pedometer;peer;Persons;Physical activity;Population;Procedures;Research;research clinical testing;Research Personnel;Scanning;Site;smart watch;smartphone application;Special Population;Technology;Testing;Thigh structure;Time;treadmill;United States National Institutes of Health;Validation;validation studies;Variant;verbal;Video Recording;Visit;Walking;wearable device;Weight maintenance regimen;Width;Work;Wrist

PROJECT_TITLE: Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: METTL3 deficiency-mediated neuronal m6A reduction contributes to neurodegeneration in Alzheimer’s disease and multiple m6A modification sites in the gene transcripts of Aβ metabolism (production and degradation) pathways have been identified by the online resources of m6A methylation profiling and m6A predictor. In the preliminary data, we found that AAV-mediated METTL3 knockdown of primary neurons increases the Aβ level and impairs the mRNA decay of the Aβ metabolism-related gene BACE1. In this application, we proposed to investigate the molecular mechanisms underlying the Aβ accumulation caused by impaired METTL3-m6A signaling in neurons with a focus on mRNA stability, translation, splicing and nuclear export of Aβ metabolism- related gene transcripts.

PI_NAMEs: ZHAO, FANPENG  (contact)

PROJECT_TERMS: abeta accumulation;abeta oligomer;Abeta synthesis;Acceleration;Affect;Affinity;age related neurodegeneration;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;Base Sequence;beta-site APP cleaving enzyme 1;Binding;Bioinformatics;Biological Process;Brain;Catalytic Domain;Cell Nucleus;Cognitive deficits;cognitive function;Complex;Cytosol;Data;Disease;Environmental Risk Factor;enzyme activity;Enzymes;Event;Functional disorder;gamma secretase;Gene Expression;Genes;Genetic;Genetic Transcription;hippocampal pyramidal neuron;Hippocampus;Human;IgG1;Impairment;in vivo;Individual;Induced Neurons;insight;interest;knock-down;lifestyle factors;Mediating;Messenger RNA;Metabolism;Methylation;Methyltransferase;mild cognitive impairment;Modification;Molecular;Molecular Target;Monoclonal Antibodies;mRNA Decay;mRNA Stability;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Nuclear Export;online resource;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Production;Proteins;Public Health;Reader;Regulation;Regulator Genes;Reporting;Risk;RNA;RNA Decay;RNA metabolism;RNA methylation;RNA Splicing;Role;secretase;Senile Plaques;Signal Transduction;Site;symptom treatment;synaptic function;Testing;Therapeutic;Therapeutic Intervention;Transcript;Translations

PROJECT_TITLE: Dysregulation of amyloid-β metabolism by impaired METTL3-m6A signaling in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Eye Disease and Disorders of Vision;Health Services;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Most of what we know about visual search comes from experiments where observers do hundreds of instances of the same task, but most searches in the world involve a search for one thing, followed by another search for something else, and so forth. We will determine if the rules, established in studies of long blocks of trials, apply to situations where different search tasks are intermixed. We will focus especially on factors known to influence errors in search and will use Emergency Department radiology as a specific real-world setting.

PI_NAMEs: WOLFE, JEREMY M (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accident and Emergency department;Automobile Driving;Behavioral;Birds;Breast;Cessation of life;Chronic Obstructive Pulmonary Disease;Complex;cost;Dangerousness;dashboard;Educational process of instructing;Environment;Event;experimental group;experimental study;Failure;forest;Head;Hybrids;imaging modality;improved outcome;Intestinal Obstruction;Laboratories;Letters;Life;Low Prevalence;Malignant neoplasm of lung;Mammographic screening;Medical Imaging;Memory;Modeling;neurophysiology;Outcome;Paper;Perception;Performance;Persons;Pneumonia;Prevalence;Process;radiologist;Radiology Specialty;Reaction Time;Reading;Research;response;rib bone structure;Running;Screening for cancer;Security;Series;Shapes;social;Stroke;Structure;Testing;Thoracic Radiography;Time;Trees;Ukraine;Visual;visual search;wasting;Work

PROJECT_TITLE: Prevalence effects in visual search: Theoretical and practical implications

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates an essential stage of the infection process of Entamoeba histolytica, a major public health problem in many developing countries. We established a method for producing infectious cysts in vitro and will now develop a procedure for reproducible, high efficiency excystation of cysts in laboratory culture, thus allowing us to study this key process. This will provide a critical foundation for future studies to develop mechanisms targeting this stage of infection as a way to reduce the spread of this disease pursuant to part of the NIH’s mission.

PI_NAMEs: INGRAM-SMITH, CHERYL JEAN (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Amebic colitis;Back;Biological Models;combinatorial;Complex;Cues;Cyst;Developing Countries;Disease;Distant;Entamoeba;Entamoeba histolytica;Entamoeba invadens;Environment;excystation;Exhibits;Foundations;Future;Genes;Genetic;Glucose;Goals;Growth;high standard;human pathogen;In Vitro;Individual;Infection;Investigation;Laboratories;Laboratory culture;Life Cycle Stages;Mediating;Metabolic;Methods;Mission;Motility;Outcome;pathogen;Persons;Physiological;prevent;Procedures;Process;Production;programs;Protocols documentation;Public Health;Reproducibility;Reptiles;Research;Role;Scientist;Signal Pathway;Signal Transduction;System;targeted treatment;Therapeutic Intervention;Translating;United States National Institutes of Health

PROJECT_TITLE: Entamoeba histolytica as the new model system for studying excystation

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]