ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE There is an urgent need to address health disparities using newer innovative approaches that intervene at multiple levels (e.g. policy, community, school, family). Implementing and evaluating such interventions is challenging and requires effective collaboration among scientists trained in diverse disciplines. The goal of this research education program is to provide behavioral and social science health researchers with training in computer-based methods (namely, systems science and data science methods) while also providing those adept in computer-based methods with foundational knowledge in the behavioral and social sciences so to as support more effective transdisciplinary research collaborations.

PI_NAMEs: NIANOGO, ROCH ;PRELIP, MICHAEL LEE;WANG, MAY C (contact);ZHOU, HUA

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;behavioral and social science;Behavioral Sciences;Big Data;Biometry;Canada;Cluster randomized trial;cohort;Collaborations;Communities;community engaged approach;Community Health;Complex;computational reasoning;Computer Models;computer science;Computer software;Computing Methodologies;Data Science;design;Development;Discipline;Disparate;early childhood;Eating;education research;educational atmosphere;Educational Curriculum;Educational process of instructing;Environment;Epidemiology;Equity;Evaluation;experience;Familiarity;Family;Foundations;Funding;Generations;Goals;Health;Health behavior;health disparity;Health Policy;Health Sciences;innovation;insight;interest;Intervention;Intervention Studies;Knowledge;knowledge integration;large datasets;learning strategy;lens;Lived experience;Mathematics;member;Methods;Modeling;multidisciplinary;obesity in children;Physical activity;Play;Policies;Policy Maker;Postdoctoral Fellow;pre-doctoral;professor;programs;Public Health;recruit;Reduce health disparities;Research;Research Personnel;research to practice;Risk;Role;Saskatchewan;scale up;Schools;Science;Scientist;skills;social health determinants;Social Sciences;summer research;System;theories;therapy development;Time;Training;Training Programs;Training Support;Translational Research;trial design;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Modelers and Storytellers: Transdisciplinary Training to Advance Community Health Intervention Research


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PI_NAMEs: WU, BEI  (contact)

PROJECT_TERMS: 2 arm randomized control trial;Adult;Alzheimer's disease related dementia;American;Area;Asian;Asian Americans;Asian population;Belief;Biological;biological adaptation to stress;Biological Assay;Blood specimen;Cardiometabolic Disease;cardiometabolic risk;caregiver interventions;Caregivers;caregiving;caregiving outcomes;Caring;Chinese;Chinese American;Chronic Disease;community collaboration;community organizations;comparison control;Conflict (Psychology);Control Groups;Counseling;COVID-19;Cultural Backgrounds;cultural values;Dementia;dementia care;Dementia caregivers;dementia caregiving;depressive symptoms;Diabetes Mellitus;Disease Management;Educational Materials;efficacy testing;Emotional;Enrollment;Ethnic Origin;evidence base;Evidence based intervention;Failure;Family;Family Caregiver;follow-up;Glycosylated Hemoglobin;group intervention;Health;health equity;health literacy;Health Policy;Health Promotion;Hypertension;improved;Individual;Inflammation;Intake;Intervention;Korean American;Koreans;Language;Linguistics;lipid metabolism;Mainstreaming;Mediating;Mediator;Mental Depression;Mental Health;Metabolic;Metabolism;metropolitan;Minority;Minority Groups;Modeling;Morbidity - disease rate;multi-component intervention;Multilingualism;New Jersey;New York;Nursing Homes;older adult;Outcome;Oxidative Stress;Patient Self-Report;peer support;Personal Satisfaction;Persons;physical conditioning;Physiological;Policies;Population;provider intervention;psychological outcomes;psychosocial;Psychosocial Factor;Public Health;Quality of life;Questionnaires;Randomized;Research;Research Project Grants;Risk;Risk Factors;Sampling;Self Management;Services;social;Social isolation;social media;social service provider;social stigma;Social support;Stereotyping;Stress;Structure;Support Groups;Testing;Translating;underserved community

PROJECT_TITLE: NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Neurodevelopmental disorders impair cognitive, social, and physical abilities and are both clinically and genetically heterogenous. The proposed studies will investigate the role of a human disease gene UBE3B in neuronal function. Our findings will shed light on the molecular mechanisms and pathways underlying neurodevelopmental disease etiology and pathology, ultimately allowing for the development of effective targeted therapies.

PI_NAMEs: VASHISTH, SHAYAL  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Acute;Affect;Amino Acids;Antibodies;autism spectrum disorder;Biochemical;Brain;Cell Culture Techniques;Cells;Child;Clinical;Co-Immunoprecipitations;Collection;Communication;comparison control;Complex;conditional knockout;Data;Defect;density;Development;Electrophysiology (science);Environment;Etiology;Exhibits;experimental study;Fellowship;Foundations;Frequencies;Genes;Genetic;Genetic Heterogeneity;Goals;Heritability;hippocampal pyramidal neuron;human disease;Immunoprecipitation;Impaired cognition;Individual;insight;Intellectual functioning disability;Knockout Mice;Knowledge;Lead;Learning;Length;Literature;Long-Term Potentiation;Mass Spectrum Analysis;Mediating;Medical center;Memory;Mentorship;Modification;Molecular;Morphogenesis;mouse model;Mus;Mutation;nestin protein;neurodevelopment;Neurodevelopmental Disorder;Neurons;Outcome Study;Patch-Clamp Techniques;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Physiologic pulse;Polyubiquitin;Post-Translational Protein Processing;postsynaptic;Predisposition;Procedures;Property;Protein Analysis;protein protein interaction;protein purification;Proteins;Proteomics;Regulation;repetitive behavior;Research;Research Personnel;Role;Signal Transduction;Site;skills;Slice;social;Social Interaction;social skills;Speech;Stable Isotope Labeling;synaptic function;Synaptic plasticity;Syndrome;targeted treatment;therapeutic development;Training;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Ultrasonics;Vertebral column;vocalization;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Elucidating the role of the E3 ubiquitin ligase UBE3B in neuronal activity


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project narrative: The Primary cilium is a cellular structure that senses extracellular environment to play critical roles in embryonic development and tissue homeostasis. Dysfunction in the structure or the function of the organelle results in pleiotropic disorders called ciliopathies, which include obesity and retinal degeneration. In this proposal, we interrogate the molecular mechanisms of the formation of the primary cilium, to get to the root of the pathogenesis of the syndrome caused by ciliary dysfunction.

PI_NAMEs: KANIE, TOMOHARU  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: base;biochemical tools;Cell Cycle;Cell membrane;Cells;Cellular Membrane;Cellular Structures;Centrioles;Centrosome;Cilia;ciliopathy;Disease;Distal;embryo tissue;Embryonic Development;Environment;extracellular;FREQ gene;Functional disorder;G1 Phase;Health Sciences;Homeostasis;Human;Lipids;Mitosis;Molecular;Monitor;Monomeric GTP-Binding Proteins;Mothers;Movement;myristoylation;Obesity;Oklahoma;Organelles;Pathogenesis;Play;Proteins;receptor;recruit;Research Project Grants;Retinal Degeneration;Role;Signal Transduction;Structure;Syndrome;Universities;Vesicle

PROJECT_TITLE: Understanding the molecular mechanisms of cilia formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_NAME: ADVAITA CORPORATION

ORG_STATE: MI

PHR: PROJECT NARRATIVE Single-cell technologies are revolutionizing the progress of biomedical research because they allow researchers to monitor the biological systems at the single-cell resolution. This project will develop a complete analysis pipeline and web-based platform able to accurately identify cell type composition from both single-cell and bulk data, infer the developmental stages and trajectories of cells, and perform cell-type-specific, systems-level analysis. This platform is expected to have a major impact in many areas where single-cell technologies are currently used, including diagnostics, drug discovery, immunology, neurobiology, and cancer research.

PI_NAMEs: IOSEF, CRISTIANA  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Academia;analysis pipeline;anti-cancer research;Area;Atlases;Automobile Driving;base;Bioinformatics;Biological;Biological Monitoring;Biological Phenomena;biological systems;Biomedical Research;Cell Extracts;cell type;Cells;cellular development;Characteristics;commercialization;comparative;Complex;Computer software;Computing Methodologies;Core Facility;cost;Data;Data Analyses;Data Set;deep learning;design;Development;Diagnostic;drug discovery;experience;experimental study;Feedback;Flow Cytometry;Gene Expression;Genes;genome-wide;Goals;gradient boosting;high dimensionality;Human;Immunology;Individual;Industry;Knock-out;Knowledge;learning algorithm;Life;Measurement;Measures;Methodology;Methods;Mission;Music;Neurobiology;Organ;Pathway Analysis;Pathway interactions;Performance;Pharmacologic Substance;Phase;Phenotype;phenotypic data;Principal Investigator;random forest;repository;Research Personnel;Resolution;Sampling;Scientist;single cell analysis;single cell sequencing;single cell technology;single-cell RNA sequencing;software development;System;Techniques;Technology;The Cancer Genome Atlas;Time;Tissues;tool;transcriptome;transcriptome sequencing;transfer learning;Translating;unsupervised learning;usability;user friendly software;web platform;Whole Organism;Work

PROJECT_TITLE: A web-based platform for robust single-cell analysis, bulk data deconvolution and system-level analysis


ADMINISTERING_IC: DK

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE In type 1 diabetes, myeloid cells in the islets can contribute to destruction or protection of the islets, yet a significant gap in knowledge remains about how the islet myeloid compartment plays such divergent roles. The processes of efferocytosis and antigen processing and presentation are key regulators of this balance. The aims we propose will elucidate the role of these processes in promoting the protective and destructive effects of islet myeloid cells in type 1 diabetes.

PI_NAMEs: FRIEDMAN, RACHEL S (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Antigen Presentation;Antigen Presentation Pathway;Antigens;Apoptotic;Autoantibodies;Autoimmune;Autoimmunity;autoreactive T cell;Beta Cell;Cell Communication;Cell Death;Cell Physiology;cell regeneration;Cells;Coupled;cytokine;Data;Dendritic Cells;Diagnosis;Disease;Disease Progression;effector T cell;Environment;Equilibrium;experimental study;Flow Cytometry;FRAP1 gene;Gene Expression Profile;Goals;Human;Image Cytometry;Immune;Immunity;immunoregulation;improved;Inflammation Mediators;Inflammatory;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Interleukin-6;islet;islet autoimmunity;Islet Cell;Islets of Langerhans;Knowledge;Lead;Lymphocyte;Macrophage;Mediating;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;new therapeutic target;NF-kappa B;non-diabetic;nuclear factors of activated T-cells;Organ Donor;Pancreas;Pathogenesis;Pathogenicity;Pathway interactions;Patients;permissiveness;Play;Population;prevent;Process;Production;protective pathway;Receptor Signaling;Regulatory T-Lymphocyte;Resistance;Role;Sampling;Severities;Signal Transduction;single-cell RNA sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic Intervention;Transcription Factor AP-1;uptake

PROJECT_TITLE: Mertk Mediated T Cell Suppression in the Pancreatic Islets During Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE – NETWORK COORDINATING CENTER The Network Coordinating Center at Mayo Clinic (NCC-MC) will facilitate and be responsible for network-wide coordination and harmonization of scientific and administrative needs of the funded UG3/UH3 centers as part of the Cancer Adoptive Cellular Therapy (Can-ACT) Network. The NCC-MC will serve as the administrative hub and coordinating center for all network-related trials and projects, including but not limited to: (1) administrative coordination of the Can-ACT Network, (2) oversight and management of biological specimens and associated policies, and (3) provision of analytic and data management support for the Can-ACT Network, including biostatistical and bioinformatics and data science collaboration and clinical and correlative data management. The infrastructure, expertise, and experience of the individuals at Mayo Clinic is extensive for the national coordination of translational and clinical cellular product-based research, making this group well- positioned to effectively function as an outstanding coordinating center for the Can-ACT Network.

PI_NAMEs: ASMANN, YAN W.;GEYER, SUSAN MICHELLE (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Administrative Coordination;Administrative Supplement;Adoptive Cell Transfers;Adult;Animal Model;anti-cancer research;Area;biobank;Bioinformatics;Biological;Biological Specimen Banks;Biometry;Cancer Center;Cell Therapy;Cells;Childhood;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;Collection;Communication;Communities;Data;Data Collection;data harmonization;data management;Data Management Resources;Data Science;Data Security;data sharing;data submission;design;Development;early phase clinical trial;electronic data;Elements;experience;Foundations;Funding;Human;Individual;Industry;Infrastructure;innovation;Institution;interest;Leadership;Malignant Neoplasms;manufacture;meetings;member;Multicenter Trials;novel therapeutics;Oncology;operation;Patients;Policies;Positioning Attribute;pre-clinical;pre-clinical research;preclinical development;preclinical study;Process;programs;Reagent;Research;Research Personnel;research study;Resources;Solid Neoplasm;Specimen;Standardization;Structure;synergism;Testing;Therapeutic;Therapeutic Agents;Translational Research;treatment response;web site;Work;working group

PROJECT_TITLE: Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Low-income populations are disproportionately burdened by tobacco use and carry a greater burden of pulmonary health inequalities related to smoking. Despite widespread usage by populations burdened by tobacco use, Federally Qualified Health Care (FQHC) systems are an under-utilized model for reducing pulmonary and other smoking-related health inequalities among disadvantaged populations. The purpose of this study is to demonstrate the feasibility, effectiveness, and cost-effectiveness of electronically delivered smoking cessation interventions via patient portals in a network of FQHC clinics.

PI_NAMEs: CASKEY, RACHEL  (contact);MATTHEWS, ALICIA K

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Address;Adult;Asthma;Attitude;barrier to care;Caring;Catchment Area;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Practice Guideline;Communities;community engaged approach;Cost Analysis;cost effective;cost effectiveness;cost-effectiveness evaluation;Counseling;design;Disparity population;economic disparity;Effectiveness;effectiveness evaluation;effectiveness/implementation design;ethnic minority;evidence base;Evidence based intervention;Goals;Guidelines;Health;health care settings;health disparity;health inequalities;Health Personnel;Healthcare;Healthcare Systems;high risk;Illinois;implementation barriers;implementation evaluation;implementation strategy;improved;innovation;Intervention;intervention delivery;Knowledge;Low income;Low Income Population;Lung;Lung Diseases;lung health;Malignant neoplasm of lung;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;neighborhood safety;novel;Outcome;patient engagement;patient navigation;patient oriented;patient population;patient portal;Patients;Persons;Pharmacotherapy;Phase;Population;Provider;Public Health;Qualifying;quitline;racial minority;Racial Segregation;Randomized, Controlled Trials;reduce tobacco use;Risk Factors;safety net;screening;Site;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Spanish;standard of care;System;Testing;Tobacco;tobacco cessation intervention;Tobacco Dependence;Tobacco use;Translating;Translations;Uninsured;United States Public Health Service;Universities;uptake

PROJECT_TITLE: Mi QUIT CARE (Mile Square QUIT Community-Access-Referral-Expansion)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Despite the fact that a substantial percent of oral dysplastic lesions progress to oral cancer, little is known regarding the molecular characteristics of the lesions that progress to cancer versus those that do not. Using advanced DNA sequencing technologies and bioinformatics methods, we will study oral dysplasias and cancers to identify biomarkers that will help to predict an individual’s risk of oral cancer. This will allow clinicians to adjust preventive measures according to risk.

PI_NAMEs: ROZEK, LAURA  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Accounting;Address;Affect;Alcohol consumption;Apoptosis;Bioinformatics;Biological;Biological Markers;biomarker discovery;biomarker identification;Board Certification;Cancer Biology;Candidate Disease Gene;candidate identification;candidate marker;carcinogenesis;Carcinoma;Cell Adhesion;Cell Cycle Checkpoint;Characteristics;Clinic;Clinical;cohort;Collaborations;colon carcinogenesis;Data;data integration;detection test;Diagnosis;disability;Disease;DNA copy number;DNA Methylation;DNA Repair;DNA sequencing;Doctor of Philosophy;Dysplasia;early detection biomarkers;Early Diagnosis;Early identification;Epidemiology;epigenetic marker;Epigenetic Process;exome sequencing;follow-up;Frequencies;Funding;Gene Expression;Genes;Genetic;Genomics;Goals;Growth Factor;Head and neck structure;Heterogeneity;histone methyltransferase;Hospitals;improved;Individual;individualized prevention;innovation;insight;Intraepithelial Neoplasia;keratinocyte;Lesion;Lesion by Stage;Light;Longitudinal cohort;Longitudinal Studies;malignant mouth neoplasm;Malignant Neoplasms;Manuscripts;maxillofacial;Methods;Michigan;Molecular;molecular marker;Molecular Profiling;Monitor;mouth squamous cell carcinoma;multiple omics;Mutation;Operative Surgical Procedures;Oral;oral carcinogenesis;Oral cavity;oral cavity epithelium;Oral Diagnosis;oral dysplasia;oral lesion;Oral mucous membrane structure;Pathologic;Pathologist;Pathway interactions;patient subsets;Patients;personalized medicine;Phenotype;Population;predictive marker;premalignant;Prevention approach;Preventive measure;progression marker;progression risk;Progressive Disease;Proliferating;prospective;Publishing;Quality of life;Recurrence;Reporting;Research;Risk;Risk Marker;risk prediction;Sample Size;Sampling;Scientist;sex;Signal Transduction;Site;Smoking;Somatic Mutation;standard care;standard of care;success;Survival Rate;T-Lymphocyte;Technology;Testing;The Cancer Genome Atlas;Time;Tissues;Training;Transcript;transcriptome sequencing;transcriptomics;tumor;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Oral Dysplasias to Carcinomas: Multi-omics Study of Progression


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE  We propose transcatheter tumoral intra-arterial delivery of immune checkpoint blockades (ICB) loaded multifunctional carriers permitting combinational local ICB immunotherapy and 90Y-radioembolization (90Y-RE) of liver cancer. Selective transcatheter tumoral intra-arterial delivery of ICB loaded Au (gold) supra-nanostructures (AuSN) will permit efficient local delivery of immunostimulatory ICB molecules, allowing an increase in the dosage and improve their safety profile. Local tumoral delivered ICB loaded AuSN will offer the potential to significantly increase the radio-immune-stimulating efficacy of 90Y-RE. This salient combination of local ICB immunotherapy and 90Y-RE using the multifunctional carriers offers the potential to significantly improve longitudinal treatment outcomes in liver cancer.

PI_NAMEs: KIM, DONG-HYUN  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 90Y;Aftercare;anti-cancer;anti-cancer therapeutic;anti-PD-L1;anti-PD-L1 therapy;Antibodies;Area;attenuation;Autoimmune;Binding;cancer cell;Cancer Etiology;Catheters;Cell Death;Cell Maturation;Cessation of life;Clinical;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;Complement;curative treatments;Cytotoxic T-Lymphocytes;Dendritic Cells;dosage;Dose;Excision;Flow Cytometry;follow-up;Gold;image guided;imaging properties;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;immunogenic cell death;Immunohistochemistry;Immunologic Stimulation;Immunologics;Immunotherapy;improved;In Vitro;Individual;Infusion procedures;Intervention;Intra-Arterial Infusions;Lead;Lesion;Ligands;liver cancer model;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;Microspheres;Monitor;Nanoimmunotherapy;Nanostructures;Normal tissue morphology;novel strategies;Oncology;Patients;PD-L1 blockade;Primary carcinoma of the liver cells;Procedures;programmed cell death protein 1;Protocols documentation;Radiation;Radiation Dose Unit;Radiation therapy;Radio;Radioembolization;Radiology Specialty;Reactive Oxygen Species;Research;Resistance;response;Risk;Rodent Model;Safety;side effect;Surface;targeted delivery;Therapeutic;Therapeutic Effect;therapy outcome;Tissues;Transplantation;Treatment Efficacy;Treatment outcome;Treatment Protocols;tumor;Tumor Tissue;Tumor-infiltrating immune cells;Up-Regulation;X-Ray Computed Tomography

PROJECT_TITLE: Local Tumoral Delivered Immune Checkpoint Blockades Immunotherapy and Radioembolization Combination Therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hundreds to thousands of genes are altered in fatty liver and type 2 diabetes, yet how these genes are regulated is not fully understood. The current proposal identifies a novel epigenetic factor called REST that coordinates the expression of hundreds of genes involved in glucose and fat metabolism. The results will fill a knowledge gap in how epigenetic factors regulate the development of fatty liver disease and type 2 diabetes.

PI_NAMEs: YANG, QIN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adipose tissue;adult obesity;Antisense Oligonucleotides;Binding Sites;Cysteine;Data;Deacetylase;Deacetylation;demethylation;Development;Disease Resistance;Energy Metabolism;Enhancers;Epigenetic Process;epigenetic regulation;Fatty Liver;fatty liver disease;Gene Expression;Genes;Genomic DNA;Gluconeogenesis;Glucose;Glucose Clamp;glucose metabolism;glucose production;glucose tolerance;glucose uptake;HDAC1 gene;Hepatic;Hepatocyte;Heterochromatin;Histone Acetylation;Histone Deacetylase;histone methylation;histone modification;Histones;Homeostasis;Human;Hyperglycemia;Hyperinsulinism;improved;inhibitor;Insulin;Insulin Resistance;insulin sensitivity;KDM1A gene;knock-down;Knockout Mice;Knowledge;lipid metabolism;Liver;Liver diseases;Maps;Mediating;Metabolic;Metabolic dysfunction;Methylation;Mitochondria;Modification;Mus;Muscle;non-alcoholic fatty liver;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Nuclear Translocation;Obese Mice;Play;programs;promoter;Protein Secretion;Proteins;RE1-silencing transcription factor;recruit;Role;Technology;tool;transcription factor;transcriptome sequencing;unhealthy lifestyle;Up-Regulation

PROJECT_TITLE: Epigenetic Regulation of Mitochondrial Homeostasis and Energy Metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative This project is focused on understanding how genome rearrangements occur in cancer with a particular emphasis on understanding how telomere shortening prevents tumorigenesis and how loss of telomere function in developing cancers changes the cancer genome. The proposed experiments will illuminate new aspects of genome instability in cancer and are designed to deliver insights that will ultimately inform and guide decisions in the cancer clinic.

PI_NAMEs: DE LANGE, TITIA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affect;Birth;BRCA1 gene;Cancer cell line;cancer genome;Cell Survival;Cells;chromothripsis;Clinic;Complex;CRISPR interference;design;Diagnosis;Dicentric chromosome;DNA;DNA Primase;DNA Repair;Excision;experimental study;fitness;Funding;Future;Genes;Genetic;Genome;Genomic Instability;Goals;in vitro Model;innovation;insight;Length;Malignant Neoplasms;Mentors;Molds;Mutation;Oncologist;p53-binding protein 1;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Prevention;recruit;repaired;Research;Research Personnel;Resected;Role;Telomerase;telomere;telomere loss;Telomere Shortening;TERF1 gene;Testing;Tissues;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Genome instability in cancer: telomeres and DNA repair


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Aneuploidy plays a major role in human health, causing debilitating developmental disorders, enabling cancer evolution, and supporting drug resistance in human pathogens. This project will study how aneuploidy inhibits quiescence, a fundamental cellular state that is important for growth control, stem cell function, and tissue renewal.

PI_NAMEs: GASCH, AUDREY  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;Aneuploidy;Bar Codes;Biological Models;Buffers;cancer cell;Cell Cycle Arrest;Cell Cycle Regulation;Cell division;Cell Maintenance;Cells;Cellular biology;Chromosome Mapping;Chromosome Segregation;Chromosomes;Chronology;Complement;Cytoplasmic Granules;daughter cell;Defect;Development;developmental disease;Disease;Down's Syndrome;Drug resistance;Edward's syndrome;Eukaryota;Evolution;exhaustion;experience;Expression Library;Fertility Disorders;Future;gene complementation;Genes;Genetic;Genomics;Glucose;Goals;Grant;Growth;Health;Human;human disease;human pathogen;Individual;Karyotype;life span;Link;live cell imaging;Malignant Neoplasms;Maps;Meiosis;Metabolic;Methods;Microscopy;Mitochondria;Mitosis;Modeling;Molecular;Nutrient;Nutrient Depletion;Organism;overexpression;Patau's syndrome;Phase;Phenotype;Plasmids;Play;Pregnancy loss;Premature aging syndrome;Process;programs;promoter;Proteins;Proteome;Proteomics;Respiration;response;RNA;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;single molecule;stem cell function;Stress;Syndrome;System;Testing;tissue regeneration;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;tumor;Work;Yeasts

PROJECT_TITLE: Understanding how aneuploidy disrupts quiescence in the model eukaryote Saccharomyces cerevisiae

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: ITHACA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE This proposal aims to develop next-generation algorithms for statistical genetics based on modern machine learning, focusing on three broad areas: modeling linkage disequilibrium and the structure of genetic variation, analyzing genome-wide association study data, and predicting risk from genetic and environmental factors. Within in each area, we aim to develop open- source systems for key applied problems including genetic imputation, haplotyping, low-pass sequencing, causal variant identification, and risk scoring. By leveraging massive data, our methods will help reveal novel genetic factors that influence disease; improve the accuracy of genomic prediction in domains from preventive medicine to pharmacogenomics; significantly reduce the cost of genomic sequencing assays; and ultimately improve human health.

PI_NAMEs: KULESHOV, VOLODYMYR  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Algorithms;Area;Biological Assay;causal variant;Clinical;Collection;Computer software;Computing Methodologies;cost;Data;Data Set;Development Plans;Disease;Environment;Environmental Risk Factor;Foundations;Genetic;Genetic Risk;Genetic Structures;Genetic Variation;Genome;genome wide association study;genomic predictors;Genomics;Genotype;Haplotypes;Health;Healthcare;Human;Human Genome;Image;improved;Link;Linkage Disequilibrium;Machine Learning;machine learning algorithm;Medical;Methods;Modeling;Modernization;next generation;novel;open source;Outcome;Pharmacogenomics;Phenotype;Preventive Medicine;Research;Risk;risk prediction;Scientist;software systems;Statistical Algorithm;System;Technology;trait;unstructured data;Vision

PROJECT_TITLE: Next-Generation Algorithms in Statistical Genetics Based on Modern Machine Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: This MIRA proposal will develop sampling algorithms at the interface of statistical mechanics and artificial intelligence to probe mechanisms for rare event processes, such as drug unbinding and conformational change in drug targets. These algorithms will be used to guide mechanistically driven design of inhibitors of Src, Abl kinases and PreQ1 riboswitches.

PI_NAMEs: TIWARY, PRATYUSH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Algorithms;Area;Artificial Intelligence;Artificial Intelligence enhanced;Awareness;Biology;Chemicals;Computing Methodologies;conformational conversion;design;Development;Dissociation;Drug Design;drug discovery;Drug Targeting;Event;Generic Drugs;Human;inhibitor;Intervention;Kinetics;Learning;learning strategy;Ligands;Maps;Methods;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;National Cancer Institute;Natural Language Processing;Nature;neural information processing;Pharmaceutical Preparations;Phosphotransferases;Process;programs;Reaction;Research;Sampling;simulation;Statistical Mechanics;Structure;Thermodynamics;Tyrosine Kinase Inhibitor;Universities;Work

PROJECT_TITLE: From atoms to mechanisms - Artificial Intelligence augmented molecular simulations for mechanistic ligand design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(07)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cerebrovascular;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative In clinical trials of drugs and other therapies to treat blinding diseases of the retina, the FDA’s recommendation is to use functional assessment, as it is likely to provide earlier indications of their efficacy. In our lab we have discovered a novel way to measure neural function at the cellular level in the living, human retina (the optoretinogram), using equipment very similar to that employed in commercial, clinical imaging systems. The optoretinogram may prove to be faster, less invasive, and more sensitive to neural dysfunction than existing functional tests. The goal of this grant is to study and improve the technology, and then demonstrate its sensitivity to disease-related dysfunction in patients with inherited retinal degenerations and early to intermediate age-related macular degeneration.

PI_NAMEs: JONNAL, RAVI S. (contact);ZAWADZKI, ROBERT J

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: adaptive optics;Affect;Age;Age related macular degeneration;Angiography;Atrophic;Biological Markers;Blindness;Bruch's basal membrane structure;Cells;Choroid;Clinic;Clinical;Clinical assessments;clinical imaging;Clinical Research;Clinical Trials;Complement;computing resources;cost;Data;Degenerative Disorder;density;Deposition;design;Development;Disease;Disease Progression;Drusen;Dryness;Electroretinography;Equipment;Eye;Eye Movements;Feedback;field study;Functional disorder;functional loss;Genes;geographic atrophy;Geographic Locations;Goals;Grant;Health;Human;Image;image processing;imaging Segmentation;imaging system;improved;Industrialization;inherited retinal degeneration;Knowledge;Length;Lesion;Light;Location;Measurement;Measures;Methods;Modification;Morphology;Motivation;Mutation;Neuronal Dysfunction;Neurophysiology - biologic function;neurovascular unit;next generation;Noise;novel;novel marker;novel strategies;operation;Optics;Outcome Measure;Pathogenicity;patient population;Patients;Persons;Pharmaceutical Preparations;Phase;Photoreceptors;Phototransduction;Physiological;Play;potential biomarker;Protocols documentation;Recommendation;Recovery;Research;research clinical testing;Resolution;response;Retina;Retinal Diseases;retinal neuron;Retinitis Pigmentosa;Role;Sequence Analysis;signal processing;Signal Transduction;Source;standard care;Stargardt's disease;statistics;Stimulus;Structural defect;structural imaging;System;Technology;Testing;Thick;Time;Translating;Treatment Efficacy;Visual Acuity;visual cycle;Visual Fields;Visualization;volunteer;Work

PROJECT_TITLE: OCT-based functional biomarkers for degenerative diseases of the photoreceptor-RPE-choroid neurovascular unit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: NARRATIVE Deep brain stimulation (DBS) for Parkinson's disease is a complementary neurosurgical treatment to dopamine replacement therapy aimed at providing more consistent motor control. This consistency, however, depends on how well stimulation settings are optimized for a given patient during a clinical visit (personalized therapy) and how well they can adapt to meet the motor control needs of the patient at any given moment (responsive therapy). This project will investigate how spatiotemporally optimized DBS settings differentially affect the four cardinal motor signs of Parkinson's disease (bradykinesia, rigidity, tremor, and postural instability) and how those behavioral changes relate to neural pathway activation through the brain's motor control network.

PI_NAMEs: JOHNSON, MATTHEW DOUGLAS (contact);NETOFF, THEODEN I

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Action Potentials;Affect;Algorithms;Anatomic Models;Anatomy;Area;Autopsy;Axon;Basal Ganglia;Behavioral;behavioral outcome;Bradykinesia;Brain;Cell Nucleus;Cells;Chronic;Clinical;Computer Models;Data;Data Set;Deep Brain Stimulation;density;Distal;dopamine replacement therapy;electric field;Electrodes;Electrophysiology (science);Elements;Face;Fingerprint;Frequencies;Functional disorder;Funding;Globus Pallidus;Goals;Grant;Image;Implant;improved;in vivo;Individual;Injections;innovation;insight;instrument;Lead;Lesion;Macaca mulatta;Magnetic Resonance Imaging;Maps;Methods;Microelectrodes;Modeling;Motor;motor control;Motor Cortex;Movement;multidisciplinary;Neural Pathways;Neurons;neurosurgery;Neurotoxins;next generation;nonhuman primate;novel;Optical Coherence Tomography;Outcome;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathway interactions;Patients;Pattern;personalized medicine;Phase;Physiologic pulse;Population;posture instability;predictive modeling;Primates;Process;Resolution;response;Severities;Site;spatiotemporal;Stimulus;Structure of subthalamic nucleus;symptomatology;Symptoms;Synaptic Transmission;targeted treatment;Thalamic structure;Therapeutic;Therapeutic Effect;Time;Tissues;tractography;Translating;translational approach;transmission process;Tremor;Visit;Visualization;Width;Work

PROJECT_TITLE: Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's Disease


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative The proposed competing renewal is a multi-site, interdisciplinary project bringing together basic, translational, computational, and clinical investigators to support critical research on pragmatics, the social language skills that are most profoundly impaired in autism spectrum disorder (ASD). Using a family study design, we examine pragmatic language profiles that extend beyond traditional diagnostic boundaries and may be linked with neural correlates and specific molecular genetic variation, studying a cohort enriched for girls, who have been historically underrepresented in studies of pragmatics in ASD. Study aims will generate findings, resources, and tools that will lead to improved understanding of the etiology and mechanistic underpinnings of pragmatic impairments in ASD.

PI_NAMEs: LOSH, MOLLY C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;analytical method;analytical tool;Auditory;autism biomarker;autism community;autism spectrum disorder;autism symptoms;Behavioral;behavioral phenotyping;biobank;Biological;Biological Markers;biological research;Biology;Clinical;clinical application;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;clinically significant;Cognitive;cohort;Complex;Control Groups;Data;data harmonization;data repository;data sharing;Development;Diagnostic;differential expression;Dimensions;Electrophysiology (science);Employment;Etiology;Family;family genetics;Family Study;Female;First Degree Relative;Friendships;Funding;Future;gaze;Genetic;genetic analysis;Genetic Diseases;Genetic Markers;Genetic study;Genetic Variation;girls;Grain;Heritability;Heterogeneity;Impairment;improved;Individual;individuals with autism spectrum disorder;Informatics;innovation;Intervention;Language;Language Disorders;language impairment;Life;life span;Link;Machine Learning;male;Measurement;Measures;Methods;Modality;Molecular Genetics;molecular marker;multidisciplinary;multimodality;Mutation;neglect;neural;neural correlate;neurophysiology;Parents;Participant;Pattern;Phenotype;pragmatic study;predict clinical outcome;prevent;Process;Psycholinguistics;Research;Research Design;Research Personnel;Resources;Rest;Risk;risk variant;Sampling;segregation;Sex Differences;Site;skills;social;Social Environment;social skills;sound;Speech;speech processing;Speech Sound;Subgroup;symptomatology;Symptoms;theories;tool;trait;Translating;translational goal;Variant;Visual;Work

PROJECT_TITLE: A Family-Genetic Study of Language in Autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Kidney disease has many causes which has made it hard to identify approaches to prevent it from developing and prevent it worsening when someone does have it. We propose a national coordinating center for the O’Brien kidney consortium that will increase collaboration in kidney disease research. Additionally, the coordinating center will have a training program and oversee a pilot grant program.

PI_NAMEs: ANDERSON, AMANDA HYRE (contact);GUTIERREZ, ORLANDO M

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Accountability;Acute Renal Failure with Renal Papillary Necrosis;Address;Alabama;Applications Grants;Area;Biometry;Caring;Chronic Kidney Failure;Clinical and Translational Science Awards;Collaborations;Common Data Element;Communication;Communities;Consultations;Data;Data Analyses;data management;data portal;data sharing;data standards;Development;drug development;education planning;Educational workshop;Ensure;Entrepreneurship;Epidemiologist;equity, diversity, and inclusion;experience;Faculty;Feedback;Focus Groups;Funding;Goals;Grant;Health;High Prevalence;Hour;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;Institution;Investments;Kidney;Kidney Diseases;Lead;meetings;Mentors;Mentorship;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Outcome;Output;outreach;Pathway interactions;patient engagement;patient oriented;Patient-Focused Outcomes;Patients;peer;peer coaching;Peer Review;Pilot Projects;Play;preference;prevent;Procedures;Productivity;programs;Protocols documentation;Published Comment;Research;Research Personnel;Research Priority;Resource Sharing;Resources;Role;Science;Scientist;Services;Societies;Students;success;synergism;Technology;tool;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;virtual;Vision;Writing

PROJECT_TITLE: UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE  Prior research has convincingly demonstrated a role for RNA in regulating PRC2’s suppression of target gene expression, but the nature and mechanism of this regulation remains unclear. The proposed studies will biophysically interrogate the mechanism(s) by which RNA regulates PRC2 activity. A mechanistic understanding of the PRC2-RNA relationship may be broadly relevant to enzymes regulating gene expression, and it could have profound implications in embryonic development and cancer.

PI_NAMEs: HEMPHILL, WAYNE OLIVER (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Binding;Biological Assay;biophysical properties;Biophysics;Cell Differentiation process;Chromatin;Complex;Data;Deposition;design;Development;Dissociation;DNA;Embryonic Development;Enzymes;epigenetic silencing;experimental study;flexibility;Fluorescence Polarization;G-Quartets;Gene Expression;Gene Expression Regulation;Genes;genomic locus;Genomics;Goals;Histone H3;histone methyltransferase;in vitro activity;in vivo;interest;Kinetics;Knowledge;Length;Literature;Lysine;Malignant Neoplasms;Mediating;methyl group;Modeling;MS2 coat protein;Nature;novel therapeutics;nucleic acid binding protein;Nucleic Acids;Nucleosomes;permissiveness;Poly(A)+ RNA;Polycomb;Polynucleotides;Prevalence;Proteins;Proxy;recruit;Recruitment Activity;Regulation;Research;RNA;RNA Binding;Role;Site;spatial relationship;Specificity;Structure;Testing;Three Prime Repair Exonuclease 1;Transfer RNA;tumor progression;Work

PROJECT_TITLE: Biophysical interrogation of the RNA-mediated mechanisms regulating Polycomb Repressive Complex 2 activity


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative/Relevance This proposed program, Biomedical Informatics Behavioral Sciences (BIBS) Summer Research Program, targets undergraduate- and graduate-level students from underrepresented minority groups and provides stipends for those interested in oral and public health to complete 9 weeks of coursework and applied research experiences. Minority populations suffer disproportionately with dental diseases, for reasons that are not always well understood, and it is our premise that a dearth of diversity among oral health researchers contributes to this knowledge gap. The BIBS program will offer short-term training in bioinformatics and data science, mentoring, and research experiences to a new cadre of students interested in advanced degrees in oral health research as well as careers in the field.

PI_NAMEs: TIMOTHE, PEGGY  (contact)

PROJECT_TERMS: Address;Advocacy;American;American Dental Association;Applied Research;Behavioral Sciences;Bioinformatics;biomedical informatics;Black race;career;Code;Collaborations;college;Community Services;Complementary Health;Complex;Computer software;Computer Systems;COVID-19 pandemic;Data;data dashboard;Data Science;data sharing;Dental;Dental Care;Dental Students;Dentistry;Dentists;Development;disadvantaged background;Disease Management;Disparity;diversity and inclusion;Education;Enrollment;Ethnic Origin;Evaluation;Event;experience;Faculty;faculty mentor;Feedback;Fostering;Future;Health;health data;health disparity;Health Professional;Health Sciences;Health Services;Health Services Research;Health Status;Health system;Healthcare;Hispanic;improved;Individual;Inequity;Infrastructure;innovation;interest;Intervention;Knowledge;large datasets;Latino Population;Learning;Link;Literature;Master of Public Health;Master of Science;medical specialties;Mentors;Mentorship;Methodology;Minority Groups;Mouth Diseases;multidisciplinary;Occupations;opioid use;Oral health;Outcome;Participant;patient/disease registry;Performance;population based;Postbaccalaureate;programs;prospective;Public Health;Public Health Informatics;Race;racism;recruit;Reporting;Research;Research Personnel;Research Project Grants;response;Risk Factors;statistical center;statistics;Students;summer program;summer research;Summer science program;Surgeon;symposium;System;Talents;Technology;Texas;Time;Tobacco use;tool;Tooth Diseases;Training;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Underserved Population;underserved students;United States;United States National Institutes of Health;United States Public Health Service;Universities

PROJECT_TITLE: The Biomedical Informatics and Behavioral Sciences (BIBS) Summer Research Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative By exploiting recent advances in our understanding of protein trans-splicing, we will develop split intein tools for incorporating chemical probes, such as crosslinkers and photosensitizers, into target proteins, including allowing access to internal regions via a concerted protein ‘transposition’ reaction. We will also develop various controllable versions of these inteins for use in both basic science and synthetic biology applications. These tools will be used to address a series of problems in the area of epigenetic (dys)regulation, and thus are expected to further our understanding of disease-specific biology.

PI_NAMEs: MUIR, TOM  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acute;Address;Adopted;Area;Award;Basic Science;Biochemical;Biochemistry;Biological;Biological Process;Biology;Biopolymers;Biotechnology;catalyst;Cell Differentiation process;Cell Physiology;cell transformation;Cells;Chemicals;Chemistry;Chimeric Proteins;Chromatin;Chromosomal translocation;Chronic;Communities;Complex;Crosslinker;Data;design;Devices;Disease;Engineering;Epigenetic Process;Event;Explosion;Foundations;Funding;Gene Expression Regulation;Generations;Genetic;Genetic Recombination;Genomics;Higher Order Chromatin Structure;In Situ;In Vitro;in vivo;intein;Label;Lead;leukemia;leukemogenesis;Ligase;Logic;Long-Term Effects;Maps;Measures;Mediating;metagenomic sequencing;metaplastic cell transformation;Methods;Monitor;Motivation;nano;National Institute of General Medical Sciences;Nature;next generation;Oncogenic;operation;Optics;Output;Paste substance;Phase;Phosphorylation;Photosensitizing Agents;Post-Translational Protein Processing;Process;programs;Protein Chemistry;protein complex;Protein Engineering;Protein Region;Protein Splicing;Proteins;Proteomics;Protocols documentation;Publications;Reaction;Reagent;Regulation;Research;Science;sensor;Series;Signal Pathway;Site;spatiotemporal;Structure;success;synthetic biology;System;Techniques;Technology;technology platform;tool;Toxin;Trans-Splicing;Translation Process;Work

PROJECT_TITLE: Structure, Function and Applications of Inteins

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Enhancer malfunction is the driver of multiple human developmental disorders and cancer. Here I propose to identify novel mechanisms underlying functions of enhancer-regulating epigenetic modifiers in pluripotent stem cells. The proposed study will advance our knowledge in the regulation of transcription and stem cell identity, which is essential to understand diseases driven by enhancer malfunction.

PI_NAMEs: CAO, KAIXIANG  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: antagonist;Area;Cell Differentiation process;Cells;Chromatin;Development;developmental disease;Disease;Embryonic Development;Enhancers;Enzymes;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genes;Health;Higher Order Chromatin Structure;histone demethylase;histone methyltransferase;Histones;Human;human disease;insight;KDM1A gene;Knowledge;Laboratories;Malignant Neoplasms;novel;Pathogenesis;Physiological Processes;Play;pluripotency;pluripotency factor;Pluripotent Stem Cells;Proteins;Reader;recruit;Regulation;Research;Role;self-renewal;stem cell differentiation;stem cell self renewal;stem cells;Transcriptional Regulation

PROJECT_TITLE: Deciphering enhancer regulation in stem cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROPOSAL NARRATIVE Inflammatory bowel disease (IBD) is a serious and debilitating condition of intestinal inflammation that is prevalent in the USA and worldwide but currently has no cure. Patients with IBD suffer from severe damage and scarring of the lining of their intestine, which protects their inner organs against insults from food and commensal microbiota in the gut lumen. The work we propose here will test a radical new idea for treatment of IBD to boost the activity of a natural cellular protein that protects cells against damage, and to reverse the injury and promote healing in the intestine.

PI_NAMEs: BLANDER, JULIE MAGARIAN  (contact);LARISCH, SARIT

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affect;Agonist;Alleles;Animal Model;antagonist;Anti-Tumor Necrosis Factor Therapy;Apoptosis;ART protein;Back;Binding;Caspase Inhibitor;Cell Death;Cell Death Induction;Cell Line;Cells;Cessation of life;Characteristics;Chronic;Chronic Disease;Cicatrix;Clinical;clinical development;Colon;commensal microbes;Crohn's disease;cytokine;Cytoprotection;Data;Disease;disease model;DNA Damage;Down-Regulation;Epigenetic Process;Epithelial Cells;Exhibits;Food;Foundations;gastrointestinal system;Gastrointestinal tract structure;Genes;Genetic;Goals;gut inflammation;healing;Hematopoietic System;high throughput screening;Host Defense;Human;Impairment;Incidence;Induction of Apoptosis;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;innate immune pathways;Interleukins;Intestinal Cancer;Intestinal Diseases;intestinal epithelium;Intestines;Knockout Mice;Lead;Methylation;microbiota;Molecular;mouse model;Mucous Membrane;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Natural regeneration;novel;novel strategies;Organ;Organoids;Output;Patients;Phenotype;Physiological;Prevalence;prevent;Prevention;pro-apoptotic protein;promoter;protein expression;protein function;Proteins;reduce symptoms;Relapse;Resistance;response;Risk;RNA Splicing;Role;small molecule;Stress;symptom treatment;System;Testing;Therapeutic;therapeutic target;TNF gene;TP53 gene;Transcriptional Activation;treatment strategy;tumor;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Ulcerative Colitis;Up-Regulation;Variant;Work;x-linked inhibitor of apoptosis protein

PROJECT_TITLE: Modulating XIAP for the Treatment of Inflammatory Bowel Disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: Boston

ORG_NAME: ARIETIS

ORG_STATE: MA

PHR: Antibiotics are not always effective due to antimicrobial resistance and this problem is increasingly causing people to die. New strategies and medicines are needed to combat antibiotic resistant infections. The purpose of this project is to evaluate compound 5192 for its usefulness as a new antibiotic.

PI_NAMEs: LAFLEUR, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acute;analog;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Bacteremia;Bacteria;Cancer Etiology;care costs;Cell Survival;Cells;Cessation of life;Classification;Clindamycin;Clinical;clinical candidate;clinical development;Coagulation Process;Collaborations;combat;Data;design;Development;Development Plans;DNA-Directed RNA Polymerase;Dose;Dose Fractionation;Drug Kinetics;Drug resistance;drug resistant bacteria;efficacy study;Endocarditis;Ensure;Enterococcus;Enterococcus faecalis;Erythromycin;Fiber;Fibrin;Foreign Bodies;Future;Genetic Transcription;Genus staphylococcus;global health;Goals;Growth;Human;Hybrids;Implant;In Vitro;in vivo;Infection;Infective endocarditis;Interphase Cell;Investigational Drugs;Lesion;Medical;Medicine;Metabolic;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Microbial Biofilms;Microbiology;Modeling;mouse model;Mus;Mycobacterium tuberculosis;No-Observed-Adverse-Effect Level;pathogen;Patient Care;Patients;Peptide Hydrolases;Periprosthetic joint infection;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phase;Pneumonia;pre-clinical;prevent;Proteins;Proteolysis;Rattus;recurrent infection;Repression;Resistance;Resistance development;resistance frequency;resistant strain;Resistant Streptococcus pneumoniae;Rifampicin resistance;Rifampin;Rifamycins;RNA;Route;Safety;safety study;Saint Jude Children's Research Hospital;scale up;Septicemia;single molecule;Streptococcus;Streptococcus Group B;Streptococcus pneumoniae;Streptococcus pyogenes;Structure;Structure-Activity Relationship;subcutaneous;success;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapy development;Thigh structure;Toxic effect;Toxicokinetics;tuberculosis treatment;Universities;Vancomycin;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Work;World Health Organization

PROJECT_TITLE: Development of a Dual-Targeting ClpP Activating Antibiotic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative This project determines the most effective policy pathways for thwarting the role of disadvantaged racially segregated neighborhoods in facilitating disparities in two breast cancer outcomes –late-stage diagnosis and mortality. Successful completion of this research will provide the necessary foundation for designing public policy interventions that focus on equity and social justice concerns for resolving disparities in various disease states.

PI_NAMEs: WHITE-MEANS, SHELLEY  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Affect;Area;Black Populations;Black race;black women;Breast;breast cancer survival;Breast Cancer survivor;cancer care;Censuses;Characteristics;Cities;Communities;community-level factor;Crime;Data;design;Diagnosis;Disadvantaged;Discipline of Nursing;Disease;Disparity;Equity;Evolution;Face;Focus Groups;food insecurity;Foundations;Future;Glean;Goals;Health;health disparity;health economics;health equity;health inequalities;Health Insurance;Health Policy;Health system;Housing;improved;Incidence;indexing;individual patient;insight;Institution;intersectionality;Intervention;Interview;Investments;Laws;Leadership;Logic;Malignant Breast Neoplasm;Measures;Mental Health Services;Methods;Minority Groups;Modeling;mortality;Neighborhoods;neoplasm registry;Outcome;Outcomes Research;Pathway interactions;Patients;physical conditioning;Policies;Policy Maker;Politics;Population;population based;Positioning Attribute;Poverty;Public Policy;Publishing;Qualifying;Race;racial disparity;Racial Segregation;Recovery;Research;residential segregation;Resources;Role;Schools;segregation;Signal Transduction;Social Change;social health determinants;Social Justice;statistics;Structural Racism;System;systemic barrier;Tennessee;Transportation;traumatic stress;Trust;White Women

PROJECT_TITLE: Policy Pathways to Breast Health Equity in Racially Segregated Areas with Concentrated Poverty

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative. Heart disease is the leading cause of death in the U.S., and manufacturing workers and communities have high rates of heart disease and its risk factors (e.g., smoking, obesity, physical inactivity, and diabetes). The proposed Healthy Hearts in Manufacturing (HHM) study will introduce evidence-based interventions for hypertension and tobacco cessation in worksite clinics that serve manufacturing workers and their families. We will evaluate whether HHM is associated with improved hypertension control and tobacco screening and cessation intervention, and estimate the health care savings for the companies and Medicare.

PI_NAMEs: MCHUGH, MEGAN  (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Healthy Hearts in Manufacturing: Improving Cardiovascular Care in Worksite Health Clinics

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed project will provide a career development program to early career investigators from historically under-represented groups who are supported by NIDDK. We will provide theory-driven and evidence-based interventions that target scientific self-efficacy and identity to increase perseverance. The goal of the program is for scholars to obtain the next appropriate level of funding to establish independent programs of research.

PI_NAMEs: FLOWERS, ELENA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adult;African American population;Area;Asian population;Award;Awareness;Biomedical Research;biomedical scientist;Black Populations;career;career development;Career Mobility;career networking;Categories;Caucasians;Collaborations;cost;Data;demographics;Development;Diabetes Mellitus;Digestive System Disorders;disability;Disadvantaged;Disease;Disparity;Doctor's Degree;Education;Educational workshop;ethnic minority population;Ethnic Origin;Evidence based intervention;experience;Faculty;Funding;Future;Gender;Goals;Grant;high school;Hispanic Populations;Human Resources;improved;Individual;information processing;innovation;Intervention;Journals;Kidney Diseases;Latinx;Literature;low socioeconomic status;Mediating;member;men;Mentors;Mentorship;Mission;Modeling;Non-Insulin-Dependent Diabetes Mellitus;outcome disparities;Participant;Persons;Phase;Population;Positioning Attribute;Postdoctoral Fellow;Prevalence;Program Development;programs;psychosocial;Publishing;Qualifying;Race;racial minority population;Reporting;Research;Research Personnel;Resources;role model;Scholars Program;Science;science, technology, engineering, mathematics, and medicine;Self Efficacy;skills;Social Impacts;Social support;Socioeconomic Status;Strategic Planning;success;support network;theories;Training;undergraduate student;Underrepresented Populations;United States;Woman;women versus men;Writing

PROJECT_TITLE: Empirically Based Career Development Program for Historically Under-Represented Early Career Trainees Supported by NIDDK


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Ubiquitination regulates virtually every cellular process in eukaryotes. Results from our study will reveal information on molecular basis of virulence of bacterial pathogens and on the mechanism of signaling in hosts, which will provide novel strategies for prevention and treatment of infectious diseases.

PI_NAMEs: DAS, CHITTARANJAN  (contact);LUO, ZHAO-QING

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Actins;Address;ADP ribosylation;Amino Acids;appendage;Arginine;Attenuated;Autophagocytosis;Back;Bacteria;Binding;Binding Sites;Biochemical;Biological Assay;Calmodulin;Cell Physiology;cofactor;Consumption;Cryoelectron Microscopy;Crystallography;Databases;Deubiquitination;Economic Development;enzyme activity;Enzymes;Eukaryota;Excision;Family;Family member;Generations;Gram-Negative Bacteria;Hand;Hydrolase;Hydrolysis;hydroxyl group;infectious disease treatment;insight;Integration Host Factors;Legionella;Legionella pneumophila;Legionnaires' Disease;Life Cycle Stages;Light;Lysine;Maintenance;Molecular;Mono(ADP-Ribose) Transferases;Natural regeneration;novel;novel strategies;Nutrient;Orthologous Gene;paralogous gene;particle;pathogen;pathogenic bacteria;Pathway interactions;Phagosomes;phosphoric diester hydrolase;Poisoning;Prevention strategy;Process;Property;Proteins;Public Health;Reaction;Regulation;Resistance;ribose phosphate;Serine;Side;Signal Transduction;Sorting;structural determinants;Structure;Toxin;trafficking;Tubular formation;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;Vesicle;virtual;Virulence;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanism of atypical ubiquitination and deubiquitination by bacterial effectors

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


PHR: Type 1 Diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta cells. T1D therapies have largely failed in human clinical trials and thus an urgent need exists for targeting novel immune pathways. We show that a TLR4-Ab can reverse acute T1D by inducing myeloid-derived suppressor cells; we will demonstrate the mechanisms of this novel treatment, and we have developed and will test a panel of human TLR4-Abs to apply this work to human T1D.

PI_NAMEs: HERR, ANDREW B;RIDGWAY, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acute;Adoptive Transfer;Agonist;Antibodies;Antibody Affinity;Antibody Therapy;autoimmune pathogenesis;Autoimmunity;Avidity;Binding;Biological Assay;biophysical analysis;biophysical techniques;Biophysics;Cell Maturation;Cell surface;Cells;clinical effect;Clinical Trials;Cryoglobulins;cytokine;Data;Diabetes Mellitus;diabetes mellitus therapy;diabetic;Diabetic Ketoacidosis;Endosomes;Generations;glycosylation;Human;humanized mouse;Hyperglycemia;IgG1;IgG3;IgG4;Immobilization;Immune;Immunoglobulin Class Switching;Immunologics;Immunology;immunoregulation;in vivo;Inbred NOD Mice;Infiltration;Inflammation;Inflammatory;innate immune mechanisms;Insulin;Insulin-Dependent Diabetes Mellitus;IRF3 gene;islet;Length;Life;Macrophage;Mediating;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Nobel Prize;novel;Paper;Pathway interactions;Patients;Peripheral;Phenotype;prevent;Process;Production;receptor;receptor binding;receptor internalization;Recombinants;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;Specificity;Structure;Structure of beta Cell of islet;Surface;T-Cell Proliferation;T-Lymphocyte;Test Result;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tissues;TLR4 gene;translation to humans;Work

PROJECT_TITLE: Mechanistic and Therapeutic Role of the TLR4 Signaling Pathway in Type 1 Diabetes


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Tissue-engineered nigrostriatal pathways (TE-NSPs), consisting of aggregates of human stem cell-derived dopaminergic neurons that extend long axon tracts within tubular hydrogels, are fabricated in vitro and implanted to reconstruct the degenerated neurons and axons of the nigrostriatal pathway in Parkinson’s disease (PD) with anatomical and physiological fidelity. We propose to characterize how TE-NSP performance compares with conventional striatal cell implants in a rat model of PD by evaluating the mechanisms of motor recovery based on innervation and connectivity patterns in the basal ganglia, dopamine release and uptake in the striatum, and neural activity in the implants. Successful completion of the proposed studies may advance TE-NSP mediated pathway reconstruction as a viable treatment strategy and set the stage for further pre- clinical and clinical studies towards the future goal of alleviating the circuitry disruptions underlying motor symptoms in patients afflicted by PD.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Address;Adhesives;Affect;Anatomy;Animal Model;Animals;Architecture;Axon;Basal Ganglia;Behavioral;biomaterial compatibility;Cell Therapy;Cells;Cessation of life;Characteristics;Clinical Research;Clinical Treatment;Confocal Microscopy;Corpus striatum structure;Dendrites;disease model;DLG4 gene;Dopamine;dopaminergic neuron;Dorsal;Electrophysiology (science);Ensure;Excision;Exhibits;Fiber;Forelimb;Future;Gene Modified;Genetic;GIRK2 subunit, G protein-coupled inwardly-rectifying potassium channel;Goals;human induced pluripotent stem cells;human stem cell-derived;Hyaluronic Acid;Hydrogels;Immunohistochemistry;Implant;implantation;improved;In Vitro;in vivo;Lesion;Limb structure;Maps;Measurement;Measures;Mediating;Medical;Methods;Modeling;Modification;Motor;motor deficit;motor recovery;motor symptom;multidisciplinary;neglect;Nerve Degeneration;nerve supply;neural;Neural Pathways;Neurites;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurons;Neurosciences;neurosurgery;nigrostriatal pathway;Optics;Outcome;Parkinson Disease;pars compacta;Pathway interactions;Patients;Pattern;Performance;Periodicity;Persons;pharmacologic;Physiological;Population;Positron-Emission Tomography;postsynaptic;preclinical study;preservation;presynaptic;Presynaptic Terminals;rabies viral tracing;Rattus;receptor function;reconstruction;Recovery;Regulation;reinnervation;repaired;response;restoration;Role;Scanning;Signal Transduction;stem cell differentiation;stem cells;Substantia nigra structure;Synapses;Synapsins;System;tau Proteins;Techniques;Testing;Time;Tissue Engineering;treatment strategy;Tubular formation;uptake;Visualization

PROJECT_TITLE: Tissue Engineered Nigrostriatal Pathway for Anatomical Tract Reconstruction in Parkinson's Disease

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Modified Public Health Relevance Section  Abnormal cortical assembly and impaired maturation of cortical circuits are thought to cause permanent cortical miswiring, and have been proposed to be a main cause underlying neurodevelopmental and psychiatric disorders. The proposed research is significant because it will provide novel mechanistic insights into how early spontaneous patterns of activity shapes cortical circuits during a sensitive temporal window for mental illness, and will evaluate how abnormal cortical maturation impacts in vivo cortical function. Such knowledge has the potential to offer new opportunities for the identification of biomarkers and for therapeutic interventions that target specific circuits at relevant ages

PI_NAMEs: BATISTA-BRITO, RENATA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Ablation;Action Potentials;Adolescent;Adult;Age;Architecture;area striata;Behavior;biomarker identification;Brain;cell type;Cells;cholinergic;Cholinergic Receptors;clinically relevant;cognitive ability;cognitive function;Critical Pathways;Data;Development;Dimensions;Early Diagnosis;Electrophysiology (science);Environmental Risk Factor;experimental study;Eye;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Goals;Head;high risk;Impairment;In Vitro;in vivo;Individual;innovation;insight;Knowledge;Lateral Geniculate Body;Life;Maintenance;Measures;Mental disorders;Methodology;Molecular;Mus;Neocortex;neocortical;Neonatal;Nervous System;neural circuit;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;Pattern;Perception;postnatal;programs;public health relevance;Research;Retina;Role;segregation;Sensory;Shapes;single-cell RNA sequencing;Slice;superior colliculus Corpora quadrigemina;Synapses;System;Testing;Thalamic structure;Therapeutic Intervention;transcriptomics;V1 neuron;Vision;Visual;Visual Cortex;visual information;visual processing;Visual System;Work

PROJECT_TITLE: Role of spontaneous activity towards the assembly and function of neocortical circuits

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: GREENVILLE

ORG_NAME: PRISMA HEALTH - UPSTATE

ORG_STATE: SC

PHR: Project Narrative The proposed Faculty Development project creates and validates an introductory sex and gender faculty development curriculum which provides faculty with the knowledge and tools to assess and revise their curricular materials, and it creates enduring sex and gender faculty development materials for use by others. This will be implemented with a select group of faculty members at the University of South Carolina School of Medicine Greenville (SOMG) to educate faculty and enable them to work with medical students to assess the renowned Lifestyle Medical Education (LMEd) curriculum at SOMG for sex and gender content, and to integrate sex and gender content into the LMEd curriculum for future faculty audiences. This project will: develop a cadre of leaders in sex and gender health among SOMG faculty and students, result in publications in sex and gender health topics and sex and gender curricular tools by SOMG faculty and students, and create enduring, widely-disseminated faculty development materials that will enable faculty to adopt sex and gender content across U.S. medical schools, thus improving population health by facilitating the provision of clinical care for women which is sex and gender specific.

PI_NAMEs: MCGREGOR, ALYSON  (contact);QUESNELLE, KELLY MOORE;ROJEK, MARY

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Address;Adopted;Adoption;American;Assessment tool;Biological;Caring;clinical care;college;Continuing Education;Country;course development;curriculum development;Disease;disparities in morbidity;education resources;Educational Curriculum;Epigenetic Process;evidence base;experience;Faculty;Future;Future Teacher;Gender;Goals;Health;health disparity;Health Occupations;Health Personnel;improved;innovation;interest;Knowledge;Lead;learning materials;Life Style;Medical;Medical Education;medical schools;Medical Students;Medicine;member;men;Morbidity - disease rate;mortality;mortality disparity;Persons;Population;population health;prisma;Program Development;Publications;Publishing;Recording of previous events;Research;Sampling;Schools;sex;Sex Education;skills;social culture;South Carolina;Students;Teacher Professional Development;Time;tool;Training;Training and Education;Translating;United States National Institutes of Health;Universities;Update;web site;Woman;Work

PROJECT_TITLE: Sex and Gender Curricular Assessment and Revision (SG-CAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(50)R]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE NCI-sponsored clinical trials represent some of the highest priority clinical trials conducted by the UF Health Cancer Center. These trials include patients seen at our center as well as those at our affiliate programs across the state. Through this Clinician Scientist Award, we will enhance the engagement of clinician scientists with prerequisite expertise in NCI-sponsored clinical trials and institutional oversight to expand the reach of these trials and opportunities for more patients to access them.

PI_NAMEs: GEORGE, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Advisory Committees;Award;Cancer Center;career;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Network;Colon;Colorectal Cancer;Committee Members;Communication;Community Clinical Oncology Program;Conduct Clinical Trials;cost;data centers;Development;Disease;Enrollment;expectation;experience;faculty support;Florida;Future;gastrointestinal;Goals;Health;Hepatobiliary;improved;Institution;Investigational Therapies;Leadership;Malignant neoplasm of anus;meetings;member;Mentorship;National Clinical Trials Network;Neurosecretory Systems;next generation;Oncology;oncology program;oncology trial;Pancreas;Patient Participation;Patients;Pediatric Oncology Group;Peer Review;Positioning Attribute;Process;Productivity;programs;Rectum;Research;Research Personnel;Scientist;Services;Specialist;statistical center;success;Voting;Wages

PROJECT_TITLE: NCI-sponsored Clinical Trial Research Specialist


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative Pregnancy has a profound impact on the physiology of a woman's body, in addition to its central role in reproduction, including a significant effect on the risk of developing breast cancer. In this proposal we will use mouse models to elucidate novel mechanisms, cell types, and pathways that are altered by pregnancy, and their involvement in cMYC oncogene function, with the long-term objective of exploiting this knowledge for the future development of strategies that decrease breast cancer risk in humans.

PI_NAMEs: DOS SANTOS, CAMILA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acute;Affect;Age;Biochemical;Birth;BRCA1 gene;Breast;Breast Adenocarcinoma;Breast Cancer Risk Factor;Breast Epithelial Cells;c-myc Genes;Cancer Model;cancer subtypes;cell type;Cells;Cellular biology;Chromatin;chromatin remodeling;cofactor;Data;Development;DNA Methylation;Enhancers;epidemiology study;Epigenetic Process;epigenome;epigenomics;Event;Exposure to;EZH2 gene;Female;Future;Gene Expression;genetic approach;Genetic Transcription;Goals;Hormones;Human;Hyperplasia;in vivo;Incidence;insight;Knowledge;Lesion;Life;Link;Machine Learning;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Tumorigenesis;Mediating;Methods;Modeling;Molecular;Morphogenesis;mouse model;Mus;novel;Nulliparity;Oncogenes;Oncogenic;Organoids;Outcome;Output;overexpression;parous;Pathway interactions;Phenotype;Physiology;post pregnancy;Pregnancy;pregnant;prepregnancy;prevent;Preventive treatment;Property;protective effect;Regulatory Element;Reproduction;Research;response;Risk;Rodent;Rodent Model;Role;small molecule inhibitor;System;Testing;Therapeutic Intervention;Tissues;Transcriptional Activation;Transcriptional Regulation;Transgenic Animals;Transgenic Mice;tumor;tumorigenesis;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE It is postulated that in MERTK mutation-associated Retinitis Pigmentosa, photoreceptors degenerate due to loss of MERTK-dependent phagocytosis in the retinal pigment epithelium (RPE). Here we posit that the crucial MERTK function is to dampen inflammation within the RPE itself, either in addition to or unrelated to its role in phagocytosis. We will compare the effect of conditional ablation of Mertk in the RPE with that of germline loss of Mertk on retinal inflammation, dissect the two functional roles of MERTK by testing mice with point mutations in Mertk that disable either the phagocytic or the anti-inflammatory function of this receptor, and investigate the effects of inhibiting JAK-STAT inflammation signaling pathway in preventing RPE inflammation and retinal dysfunction.

PI_NAMEs: FINNEMANN, SILVIA C;GHOSH, SOURAV ;ROTHLIN, CARLA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3 year old;Ablation;Animal Model;Anti-Inflammatory Agents;Biological Assay;Biological Process;Blindness;Cell Culture Techniques;Characteristics;CISH gene;Clinical;college;Complement;Data;design;Disease;Dissection;Dose;early onset;Etiology;Event;Eye;FDA approved;Foundations;Functional disorder;Gene Expression;Genetic;Germ Lines;glial activation;Homeostasis;Human;In Vitro;Infiltration;Inflammation;Inflammatory;inhibitor;insight;ITIM;JAK1 gene;Knock-out;loss of function;Mediating;MERTK gene;Microglia;Modality;monocyte;mouse model;Muller's cell;Mus;Mutant Strains Mice;Mutate;Mutation;novel;novel therapeutics;Outcome;paralogous gene;Pathologic;Patients;Phagocytes;Phagocytosis;Phagocytosis Inhibition;pharmacologic;Phenocopy;photoreceptor degeneration;Photoreceptors;Point Mutation;postnatal;preservation;prevent;Process;Rattus;receptor function;Receptor Protein-Tyrosine Kinases;reconstitution;Regimen;Reporting;Retina;Retinitis Pigmentosa;Rodent;Role;Severities;Signal Pathway;Signal Transduction;Site;small hairpin RNA;small molecule;Source;STAT3 gene;Structure;Structure of retinal pigment epithelium;Surgeon;Tamoxifen;Testing;Therapeutic;therapeutic target;translational study;treatment duration;treatment optimization;Tyrosine;Visual Fields

PROJECT_TITLE: Inflammation in MERTK-dependent retinitis pigmentosa

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Cancer;Hematology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative STAT5 is an attractive therapeutic target for human acute leukemia and other types of human cancer. This project has the objective to develop a first-in-class of STAT5 degrader for the treatment of human cancers with hyperactive STAT5.

PI_NAMEs: WANG, SHAOMENG  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Acute T Cell Leukemia;Affinity;anticancer activity;Award;Binding;cancer cell;Cancer cell line;cancer therapy;cell growth;Cell Line;Cells;Charge;Chronic;Clinical Trials;Complex;Data;design;Development;Dimerization;Dose;Drug Kinetics;gain of function mutation;Genetic Transcription;Goals;Hematopoietic;Homo;Human;Hyperactivity;in vitro activity;in vivo;inhibitor;Investigation;Janus kinase;Laboratories;Ligands;Lymphoma;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Melanoma;member;Metabolic;mouse model;Mus;Mutate;novel therapeutic intervention;novel therapeutics;Permeability;Pharmacodynamics;Phosphorylation;Phosphotransferases;Phosphotyrosine;preclinical development;Protac;Protein Degradation Induction;Proteins;Reporting;Schedule;Sequence Homology;Signal Induction;small molecule;small molecule inhibitor;Solid;Specificity;src Homology Domains;STAT protein;STAT3 gene;STAT5B gene;STAT6 gene;Structure;T-Cell Prolymphocytic Leukemia;T-Lymphocyte;Technology;Therapeutic;Therapeutic Agents;therapeutic target;Toxic effect;Transcription Coactivator;transcription factor;Transducers;tumor;tumor progression;Tumor Tissue;tumor xenograft;Xenograft Model

PROJECT_TITLE: Small-molecule degraders of STAT5

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_DEPT: SURGERY

PHR: NARRATIVE This proposal aims to improve the early detection of head and neck cancers by applying an innovative, deep spatial omic technology and computational tools to quantitatively differentiate benign from premalignant lesions and identify prognostic immune-based signatures that assess the risk of transformation from premalignant to malignant disease. A better understanding of the molecular and immune characteristics of dysplastic lesions is needed for improving oral lesion classification relevant to predicting cancer progression, which can impact cancer prevention and treatment.

PI_NAMEs: PAI, SARA ISABEL (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acceleration;Address;Algorithms;Antitumor Response;Artificial Intelligence;Atlases;Benign;Biological Markers;Biopsy;Biopsy Specimen;cancer cell;cancer diagnosis;cancer invasiveness;cancer prevention;cancer therapy;carcinogenesis;Cells;Characteristics;Classification;Clinical;clinical application;cohort;computerized tools;Data Set;Development;Diagnostic tests;Disease;Early Diagnosis;Early Intervention;Enrollment;Epithelium;Equilibrium;experience;Genetic;Genetic Transcription;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Hematoxylin and Eosin Staining Method;Heterogeneity;high risk;Histologic;Immune;immune resistance;Immune response;Immune system;immunogenicity;Immunohistochemistry;Immunologic Markers;Immunologics;improved;Incidence;innovation;insight;Lesion;Loss of Heterozygosity;Machine Learning;Malignant - descriptor;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Modeling;Modification;Molecular;new technology;Oral;Oral cavity;Oral Characters;oral dysplasia;oral lesion;Oral Leukoplakia;Oral Stage;Patients;Phase;Population;predictive marker;premalignant;Premalignant Cell;Prevalence;prognostic;Prognostic Marker;programs;prospective;protein expression;Resected;response;Risk;Risk Assessment;Risk Factors;risk prediction;Sampling;single-cell RNA sequencing;Smoking History;Squamous cell carcinoma;Stains;standard of care;Stromal Cells;System;Techniques;Technology;Testing;Time;Tissues;Tobacco;Tobacco use;tool;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;tumorigenesis;United States;Update;Variant;World Health Organization

PROJECT_TITLE: Early detection and risk of head and neck cancer through immune based spatial omics


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed study addresses the following public health problems among women with advanced cancer: (1) lack of skills training to equip patients with the skills necessary to engage in patient-centered care (“self- advocacy”), (2) declines in quality of life and high rates of cancer- and treatment-related symptom burden, and (3) fragmented healthcare systems that place the burden on patients to navigate their care proactively. Healthcare clinicians should be concerned about patients who cannot self-advocate because these patients cannot effectively participate in their care and experience worse health outcomes compared to patients who can self-advocate. It is imperative to equip patients with self-advocacy skills so that they can address the challenges associated with advanced cancer (e.g., complex treatment decisions, difficulty communicating with healthcare providers, and barriers to managing social support) and ensure they receive care that reflects their values, preferences, and beliefs.

PI_NAMEs: THOMAS, TERESA HAGAN (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: 3-Dimensional;Address;Adult;Adult women;advanced breast cancer;Advanced Malignant Neoplasm;Advocacy;Advocate;Age;Applied Skills;behavior change;Behavioral;Behavioral Mechanisms;Belief;Breast;cancer care;cancer diagnosis;care coordination;Caring;Communication;Communication difficulty;Complex;Decision Making;Education;Educational process of instructing;efficacy evaluation;efficacy testing;Elements;Emergency Situation;enhanced care;Ensure;experience;experimental group;Exposure to;Face;Feedback;Future;Goals;Health;health care service utilization;Health Personnel;Healthcare;Healthcare Systems;Hospitalization;improved;improved outcome;Individual;individualized feedback;innovation;Intervention;intervention effect;Interview;Knowledge;Learning;learning outcome;Learning Skill;Life;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;Modeling;Motivation;Newly Diagnosed;novel;Outcome;Paper;Participant;Patient Education;Patient Preferences;Patient Self-Report;Patient-Centered Care;Patient-Focused Outcomes;Patients;Personal Satisfaction;pilot trial;poor health outcome;preference;primary outcome;programs;provider communication;Public Health;Quality of Care;Quality of life;Randomized;randomized, clinical trials;Reporting;Research;Rewards;Risk;Sampling;secondary outcome;skill acquisition;skills;skills training;Social support;success;Surveys;Symptom Burden;symptom management;Symptoms;Technology;Testing;theories;Theory of Change;Training;Transference;treatment adherence;treatment as usual;Video Games;Visit;Woman;Work

PROJECT_TITLE: Efficacy of a self-advocacy serious game intervention for women with advanced cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  We propose the continuation of the Oklahoma Pediatric Clinical Trials Network (OPCTN) as a site in the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN). The goal of the OPCTN is to provide access for the under-represented and rural populations of children in Oklahoma to state-of-the-art clinical trials and the transfer of findings that will benefit the health of those children. We will accomplish this goal by utilizing the OPCTN infrastructure to enhance capacity by providing opportunities for clinically trained junior faculty to gain experience in the conduct of clinical trials, utilizing ISPCTN trials to provide access for Oklahoma’s children, and providing support to the ISPCTN network through engagement in the development and implementation of clinical trials designed to emphasize participation by our population.

PI_NAMEs: BOGIE, AMANDA L;TRYGGESTAD, JEANIE BEATRICE;VANWAGONER, TIMOTHY M (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Address;Adult;African American;Airway Disease;American Indian Population;American Indians;Area;behavioral health intervention;Cancer Center;care systems;Child;Child Health;Child health care;Childhood;Clinical;Clinical Informatics;Clinical Investigator;Clinical Research;Clinical Sciences;clinical trial implementation;clinical trial participant;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communities;Community Developments;community engagement;Community Medicine;Community Outreach;community research;Conduct Clinical Trials;County;design;Development;Diabetes Mellitus;Economics;Enrollment;Ethnic Origin;Evaluation;experience;Faculty;Family;feasibility trial;Geography;Goals;Growth;Health;Health Benefit;Health Personnel;Health Sciences;Health Services Accessibility;Health Status;Healthcare;Home;improved;Income;informatics infrastructure;Infrastructure;interest;Journals;Latino;Leadership;Learning;Life;Medical;Medical Informatics;medical schools;member;Mentors;Multi-Institutional Clinical Trial;Nature;Network Infrastructure;neurodevelopment;Nursing Faculty;Obesity;Oklahoma;Outcome;Outcome Study;Overweight;pediatric department;Perinatal;Phase;Physicians;Population;Positioning Attribute;postnatal;practice-based research network;prenatal;Primary Health Care;Provider;Publications;Race;recruit;Research;Research Personnel;Research Priority;Research Project Grants;research study;Resource Informatics;Resources;Rural;Rural Community;Rural Population;rural underserved;Schools;Site;Smoking;statistics;System;Training;Translational Research;trial design;tribal health;Underrepresented Populations;Underserved Population;United States;Universities;Urban Community;urban minority

PROJECT_TITLE: The Oklahoma Pediatric Clinical Trials Network