ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Fetal Tissue;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Malformations of the oral cavity are among the most common birth defects in the US. Progress in design of therapeutic interventions is delayed by an incomplete understanding of the genetic underpinnings of these disorders and our inability to create models of relevant oral cell types from induced pluripotent stem cells. We propose to use spatial transcriptomics on donated human fetal tissue, to reveal details of gene regulatory networks regulating differentiation of relevant oral cell types, and to design growth factor cocktail paradigms to create these cell types in vitro.

PI_NAMEs: CORNELL, ROBERT AARON;MATHIEU, JULIE ;RUOHOLA-BAKER, HANNELE  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Affect;Artificial Intelligence;ATAC-seq;Atlases;Candidate Disease Gene;Cell Differentiation process;cell type;Cells;Cleft Lip;Code;Computational algorithm;Conceptions;Conceptus;Congenital Abnormality;craniofacial development;craniofacial disorder;Data Set;Dental;design;Development;Disease;disorder risk;DNA;effectiveness testing;Embryo;Engineering;Epithelium;Etiology;experimental study;Face;fetal;Fetus;Fishes;Gastrula;Gene Expression;Gene Expression Profile;Gene Mutation;gene regulatory network;Genes;Genetic;Genetic Counseling;genome wide association study;Goals;Growth Factor;Heritability;Heterogeneity;Human;human fetus tissue;human induced pluripotent stem cells;human tissue;Hypodontia;improved;In Vitro;Individual;induced pluripotent stem cell;Inherited;Knowledge;Learning;Ligands;Linkage Disequilibrium;Location;loss of function;malformation;Medial;member;Mesenchymal;Mesenchyme;Methods;model organism;Modeling;Morphogenesis;Multiomic Data;multiple omics;Mus;Mutation;network models;Neural Crest;Newborn Infant;Oral;Oral cavity;oral cavity epithelium;oral ectoderm;orofacial cleft;outcome prediction;Palate;paralogous gene;Pathogenicity;Patients;Periderm;permanent tooth;Preventive therapy;Protocols documentation;Resolution;Risk;Rodent;Salivary Glands;scaffold;Secondary Palate;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;spatiotemporal;stem cell therapy;Structure;Testing;TGFB3 gene;Therapeutic Intervention;Time;Tissues;Tooth structure;transcription regulatory network;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;virtual;Zebrafish

PROJECT_TITLE: Genetic underpinnings of craniofacial disorders explored with spatial sequencing


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Our training program seeks to train physicians and surgeons in the design and execution of high-quality clinically relevant cardiovascular research. The program is designed to enhance and ensure the development of academic leaders by acquiring broad-based scientific knowledge. Highly qualified applicants, with an excellent representation of minorities and women, have filled all slots within the training program.

PI_NAMEs: ABDALLA, MARWAH ;ARGENZIANO, MICHAEL ;MARX, STEVEN O (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TITLE: Postdoctoral Training in Cardiovascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Evaluating interventions that consider both social communication and disruptive behavior strategies is critical for children with autism spectrum disorder (ASD) who have challenges in both domains, which limit a family's participation in everyday activities. Understanding when, in what sequence, and how best to teach parents to use social communication and disruptive behavior interventions is critical to reducing family burden and increasing the efficiency and efficacy of each intervention. Developing and evaluating interventions for children with ASD supports NIDCD's mission of behavioral research aimed to support social communication in children with ASD.

PI_NAMEs: ROBERTS, MEGAN Y (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 9 year old;adaptive intervention;adult with autism spectrum disorder;Affect;Age Months;autism spectrum disorder;autistic children;Behavior;Behavior Therapy;behavioral outcome;Behavioral Research;Characteristics;Child;Communication;Communication difficulty;cost;design;Development;Diagnosis;Disruptive Behavior Disorder;Early identification;Educational process of instructing;Exhibits;Family;family burden;Feedback;Frequencies;Goals;implementation intervention;improved;in vivo;Individual;Instruction;Intervention;Joints;Learning;Life;Link;Manuals;Measures;Mediating;Mediator;Methods;minimally verbal;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Outcome;parenting intervention;Parents;Play;Prevention;Randomized;randomized trial;Research;Role;Sequential Multiple Assignment Randomized Trial;skills;social communication;social learning;teacher;trial design

PROJECT_TITLE: Optimizing Outcomes through Sequencing Parent-Mediated Interventions for Young Children with Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Endothelial cell migration and cell-cell interactions are fundamental processes mediating physiological angiogenesis and they are often dysregulated in human diseases. The proposed project will define how these processes regulated in time and space and identify components of this regulation. The proposed studies will reveal important factors regulating angiogenesis and guide future development of potential therapeutic strategies.

PI_NAMEs: KARGINOV, ANDREI V (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Adherens Junction;Affect;angiogenesis;Blood Vessels;cadherin 5;Cell Communication;cell motility;Cell-Cell Adhesion;Cells;Cytoskeleton;Development;Endothelial Cells;Endothelium;Engineering;Environment;Event;Extracellular Matrix;Extracellular Matrix Degradation;Future;Goals;Growth Factor Receptors;human disease;Integral Membrane Protein;Intercellular Junctions;Invaded;KDR gene;Laboratories;Light;Location;Mediating;migration;novel;optogenetics;Permeability;Phosphorylation;Physiologic Neovascularization;Physiological;Process;Regulation;Research;Role;Signal Transduction;spatiotemporal;Sphingosine-1-Phosphate Receptor;src-Family Kinases;Stimulus;Structure;Therapeutic;Time;tool;Vascular System;Work

PROJECT_TITLE: Regulation of endothelial cell invasion, migration and cell junction plasticity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Working with independently owned restaurants, a common source of calorie-rich, nutrient-poor foods in predominantly minority, low-income urban neighborhoods, has the potential to improve dietary quality, and contribute to cancer prevention. This study uses systems science approaches to sustainably improve access to healthier foods in independently owned restaurants by: 1) testing the effects of a novel intervention called FRESH (Focus on Restaurant Engagement to Strengthen Health) on dietary quality, health indicators and other outcomes in African American and Latinx communities, and 2) developing a system dynamics model to allow stakeholders to virtually test FRESH strategies in their own communities. The resulting restaurant intervention simulation model offers potential cost savings from avoided trial-and-error testing, and will support community-based cancer prevention.

PI_NAMEs: COLON-RAMOS, URIYOAN ;GITTELSOHN, JOEL  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;African American;Area;Attention;Baltimore;Behavior;Beverages;Black race;Calibration;Calories;cancer prevention;cancer risk;Cities;Communities;community advisory board;Complex;Conflict (Psychology);Cost Savings;dashboard;Data;dietary;District of Columbia;dynamic system;Educational workshop;Environment;Environmental Risk Factor;Evidence based intervention;Exhibits;experimental study;Food;Food Access;food environment;food preparation;Health;Health Food;Healthy Eating;Improve Access;improved;indexing;insight;Intervention;Interview;Intuition;Latinx;Lead;Low income;Malignant Neoplasms;Methods;metropolitan;Minority;minority communities;model building;Modeling;models and simulation;mortality;Neighborhoods;Not Hispanic or Latino;novel;Nutrient;nutrition;Online Systems;Outcome;Output;Persons;Positioning Attribute;Prevention strategy;Preventive;primary outcome;Process;protective factors;Psychosocial Factor;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Restaurants;Sales;Science;secondary outcome;Side;Site;Source;stem;System;Testing;theories;tool;urban minority;user-friendly;virtual;Visual;Visualization;willingness;Work

PROJECT_TITLE: Systems Science Approaches to Improve Access to Healthier Foods: The FRESH Trial


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Modern cancer research requires investigators who are skilled in a wide variety of advanced and innovative laboratory techniques and knowledge in both gene expression regulation and the fundamental of tissue/organ development and homeostasis. These Cold Spring Harbor annual three-week short courses offer specialized training in a residential setting that immediately impacts the progress of the trainees’ research. The courses also promote collaboration and exchange of ideas between faculty and trainees, and thus represent a significant and valuable investment towards accelerating cancer research by educating select cadres of researchers in the latest methods and concepts in these disciplines.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Acceleration;Adult;anti-cancer research;Area;Attention;Biochemical;Biochemistry;Cancer Biology;Cancer Center;Cellular biology;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Course Content;Development;Discipline;Disease;Educational process of instructing;Educational workshop;Embryo;Embryonic Development;Engineering;Ensure;Environment;Epigenetic Process;Eukaryotic Cell;experience;Exposure to;Faculty;Funding;Gene Expression;Gene Expression Regulation;Genetic;graduate student;Growth;Homeostasis;human disease;human model;Incentives;Individual;induced pluripotent stem cell;innovation;instructor;Investments;Knowledge;Laboratories;Laboratory Study;Learning;lecturer;lectures;Malignant Neoplasms;medical specialties;Methodology;Methods;Modernization;Molecular Biology;Molecular Genetics;mouse development;mouse model;Mus;next generation sequencing;Oncogenic;organ growth;Organogenesis;Postdoctoral Fellow;Principal Investigator;programs;Regulation;Reporting;Research;Research Personnel;Scientist;Series;skills;stem cell biology;stem cell technology;stem cells;Students;Techniques;Technology;Time;Tissues;Training;Update;Whole Organism;Work

PROJECT_TITLE: Cold Spring Harbor Laboratory Cancer Workshops

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it seeks to develop personalized anti-tumor vaccines, focusing here on the childhood malignancy neuroblastoma. The research is highly relevant to the NIH mission and the urgent unmet need of developing rational evidence-based therapeutic and relapse preventative strategies to reduce the health burden of cancer. This integrated multiple principal investigator project is designed to catalyze improved cure rates with decreased morbidity for patients with high-risk neuroblastoma, and many advances will be applicable to the field of cancer in general.

PI_NAMEs: MARIS, JOHN M (contact);SCHOENBERGER, STEPHEN PHILIP

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Activities of Daily Living;adaptive immune response;Adaptive Immune System;adaptive immunity;Affinity;Allografting;Antigen Receptors;Antigens;Biological Models;Cancer Burden;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell membrane;Childhood;Childhood Malignant Brain Tumor;Childhood Solid Neoplasm;chimeric antigen receptor;Clinical Trials;clinically relevant;Combined Modality Therapy;Credentialing;Data;Dendritic Cells;density;design;Development;Disease;Disease remission;disorder risk;Engineering;Epigenetic Process;Epitopes;Evaluable Disease;evidence base;Exhibits;exome sequencing;experience;FDA approved;Generations;Genetic Transcription;Genetically Engineered Mouse;Goals;Grant;Health;high risk;HLA Antigens;Human;Immune response;Immunize;immunogenic;immunogenicity;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;Incidence;Individual;Infiltration;Infrastructure;innovation;Lipids;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Mission;Monoclonal Antibodies;Morbidity - disease rate;Motivation;mouse model;Mus;Mutation;MYCN gene;nanoparticle;neoantigens;Neoplasm Metastasis;Neuroblastoma;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;Outcome;overexpression;Patient-Focused Outcomes;Patients;Peptide Vaccines;Peptides;personalized cancer vaccines;Phenotype;Polymers;pre-clinical;preclinical evaluation;predictive tools;Prevention;Prevention strategy;Principal Investigator;Proliferating;Proteins;proteogenomics;Public Health;Publishing;Relapse;relapse prediction;relapse prevention;Research;Residual Neoplasm;Resistance;response;Sampling;self assembly;sialogangliosides;Specificity;Specimen;standard of care;Survival Rate;Sympathetic Nervous System;System;T cell response;T-Cell Receptor;Testing;Therapeutic;Toxic effect;transcriptome sequencing;Transgenic Mice;Treatment Efficacy;tumor;Tumor Specific Peptide;Tumor-infiltrating immune cells;United States National Institutes of Health;vaccination strategy;vaccine development;vaccine evaluation;vaccine formulation;vaccine platform;vaccine strategy;vaccine trial;Vaccines;Validation

PROJECT_TITLE: Personalized neuroblastoma vaccines


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Precision Medicine

ORG_CITY: Columbus

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative About 13% of US adults, some 30 million people, suffer from nasal sinus disease. Although nasal obstruction and smell loss are two of the major symptoms of the disease that are crucial to disease management, currently we lack clinical tools to effectively evaluate the mechanisms contributing to these symptoms. The proposed study aims to develop novel clinical tools to better evaluate and relieve patients’ nasal obstructive symptoms and to enable patients and clinicians to make more informed, personalized decisions regarding treatment strategy.

PI_NAMEs: ZHAO, KAI  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Adult;Affect;Afferent Pathways;Air;Air Movements;airway obstruction;Anosmia;Blinded;Breathing;Chemicals;Chronic;Client satisfaction;Clinical;Clip;Data;Devices;Disease;Disease Management;effective therapy;efficacy testing;Environment;Etiology;experience;Eye;Feedback;Functional disorder;Future;Glass;Goals;Health Expenditures;Healthcare;Hearing Aids;Hypertrophy;Impairment;improved;Individual;Inferior nasal concha;invention;Knowledge;Lead;Learning;Legal patent;Link;Liquid substance;Maps;Measurement;mechanical stimulus;Medical;Methods;Modeling;Mucous Membrane;nasal obstruction;National Health Interview Survey;Nose;notch protein;novel;novel therapeutics;Obstruction;Odors;Olfactory Pathways;Operative Surgical Procedures;Outcome;Outcomes Research;participant enrollment;Pathway interactions;patient population;patient subsets;Patients;Pattern;Perception;Peripheral;personalized decision;personalized medicine;Persons;prevent;Publishing;Quality of life;reduce symptoms;Route;Sensory;sensory feedback;sensory input;sensory stimulus;Series;Sinus;standard of care;Structure;Structure of mucous membrane of nose;Suicide attempt;Surgeon;surgery outcome;symptom treatment;Symptoms;Syndrome;Testing;Therapeutic;tool;Training;Treatment outcome;treatment strategy;Trigeminal System

PROJECT_TITLE: Novel mechanisms and therapeutic approaches for nasal obstruction and olfactory losses

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: This study aims to examine differentiation of pathological synovial fibroblasts in the joints of patients with rheumatoid arthritis. We identified Notch signaling as a novel regulator of synovial fibroblast differentiation. Understanding how Notch signaling regulates synovial fibroblasts function may provide new therapeutic strategies to block pathological fibroblast differentiation by targeting Notch signaling.

PI_NAMEs: WEI, KEVIN S (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Arthritis;Attenuated;Automobile Driving;Behavior;Bioinformatics;Biological Assay;Biology;career development;Cells;Communication;Computational Biology;CRISPR/Cas technology;cytokine;Data;design;Development Plans;differentiation in vitro;Doctor of Philosophy;Environment;Exhibits;Experimental Arthritis;Faculty;Fibroblasts;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;high dimensionality;Hospitals;Immunology;Inflammatory;Inflammatory Arthritis;insight;Invaded;joint inflammation;joint injury;Joints;Leukocytes;Mediating;medical schools;member;Mentors;Mesenchymal;Modeling;Molecular;mouse model;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;new therapeutic target;notch protein;NOTCH1 gene;NOTCH3 gene;novel;novel therapeutic intervention;Organoids;Pathogenicity;Pathologic;Pathology;Patients;pharmacologic;Phenotype;prevent;programs;Receptor Activation;Receptor Signaling;recruit;Regulation;Research;Research Personnel;Rheumatism;Rheumatoid Arthritis;rheumatologist;Role;Signal Transduction;single cell analysis;single cell technology;single-cell RNA sequencing;Synovial Fluid;Synovitis;System;Systemic Lupus Erythematosus;tenure track;Testing;Therapeutic;therapeutic target;Tissue Model;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptomic profiling;Transgenic Mice;Woman

PROJECT_TITLE: Pathogenic fibroblast differentiation in rheumatoid arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative We will develop mass spectrometry methods to discover sensitive fluid biomarkers for primary tauopathies and test whether measures in blood reflect measures in cerebrospinal fluid. If fluid biomarkers of primary tauopathies are available, it can be used more widely and help with diagnoses and clinical trial designs.

PI_NAMEs: SATO, CHIHIRO  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Aliquot;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Antibodies;Benchmarking;Binding;Biological Assay;Biological Markers;biomarker performance;Blood;Blood Tests;blood-based biomarker;Brain;Brain Pathology;brain tissue;candidate marker;Central Nervous System;Cerebrospinal Fluid;Clinic;Clinical Trials Design;cohort;Cohort Studies;comparison control;Control Groups;corticobasal degeneration;Data;Development;Diagnosis;Digestion;Frontotemporal Lobar Degenerations;Goals;Human;imaging biomarker;Immunoprecipitation;Individual;Liquid substance;Mass Spectrum Analysis;Measures;Mental disorders;Methods;Microtubules;Molecular Profiling;mutation carrier;Nervous System Disorder;Neurodegenerative Disorders;novel;Pathologic;Pathology;Patients;Peptides;Pick Disease of the Brain;Plasma;Population;Preparation;Procedures;Progressive Supranuclear Palsy;Protein Isoforms;Qualifying;Research;Resources;Sampling;Sensitivity and Specificity;Site;Subgroup;tau Proteins;tau-1;Tauopathies;Testing;Tissue Sample;Translating

PROJECT_TITLE: Fluid biomarkers in primary tauopathies

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: This SEPA project aims to provide underrepresented bilingual students with the opportunity to take part in a 17-month education program with a culturally relevant pedagogy and STEM plus health content to support students' pathway a career in STEM-health disciplines. The objectives of this proposal will have a significant impact on STEM-health disciplines by preparing bi-and multilingual students who are interested in health service professions to improve ethnic and linguistic diversity in STEM and health. The data from this project will be used to guide future STEM and healthcare pipeline education programs to support underrepresented bilingual students.

PI_NAMEs: DAGDA, RUBEN K (contact);SALIDO-SANCHEZ, JAFETH

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Address;Administrator;Adult;aging population;Attitude;Automobile Driving;Awareness;bilingualism;Biological;Businesses;career;career awareness;Career Choice;Career Exploration;Censuses;Child;cohort;college;College Preparation;Communication Barriers;Communities;Community of Practice;Community Outreach;comparison group;comparison intervention;computer science;County;cyber security;Data;design;Discipline;Diverse Workforce;economic disparity;Education;Educational Curriculum;eleventh grade;Engineering;engineering design;Enrollment;Environment;equity, diversity, and inclusion;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;expectation;experience;Exposure to;Face;Faculty;Family;family support;First Generation College Students;Foundations;Funding;Future;General Population;Generations;Geography;Graduate Education;Graduate Enrollment;graduate student;group intervention;Growth;Health;health disparity;Health Occupations;Health Professional;Health Services;Healthcare;high school;High School Student;higher education;Household;improved;interest;International Migrations;Intervention;junior high school;Knowledge;Language;Latino Population;Laws;Learning;learning community;Linguistics;Literature;Mentors;Mentorship;Modeling;Morals;Multilingualism;Nature;Nevada;Next Generation Science Standards;nonEnglish language;Outcome;outreach;Parents;Pathway interactions;pedagogy;peer;Population;Positioning Attribute;preference;Process;Professional counselor;programs;public health research;Quality of Care;Race;racial diversity;Readability;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Rural;Rural Community;school district;Schools;Science;Science, Technology, Engineering and Mathematics;Self Efficacy;Services;social;social capital;social cognitive theory;Spanish;Spanish/English;Standardization;STEM career;STEM program;Students;suburban communities;success;Syndrome;System;teacher;Teacher Professional Development;Training;Training Programs;Translating;Urban Community;Work;X Inactivation;Youth

PROJECT_TITLE: CBESS: a pipeline program to increase linguistic and geographic diversity in STEM + health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative/Abstract Chronic joint destruction is a primary source of morbidity in rheumatoid arthritis (RA). Despite advances in treatment, there are currently no therapies which target both immune and stromal/bone pathology in RA. This goal of this application is to better understand the biology of the CD47 pathway in RA and to investigate whether treatments targeting this pathway can serve as novel therapeutic strategies which may not only treat but possibly reverse arthritis and bone destruction.

PI_NAMEs: KORMAN, BENJAMIN DOUGLAS (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;American;Anti-CD47;antigen processing;Arthritis;arthritis therapy;Binding;Biological Products;Biological Response Modifier Therapy;Biology;bone;bone erosion;bone loss;CD47 gene;Cell Physiology;Cells;Chronic;chronic autoimmune disease;Clinical;Clinical assessments;clinical remission;Collagen Arthritis;Combined Modality Therapy;cytokine;Data;Degenerative polyarthritis;disability;Disease;Disease remission;DNA Sequence Alteration;Drug Screening;Eating;effectiveness evaluation;Fibroblasts;Fibrosis;Gene Expression;Genomics;Goals;Histologic;Histology;Homeostasis;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;innovation;insight;joint destruction;Ligands;Macrophage;Malignant Neoplasms;Membrane Proteins;Mesenchymal;migration;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;novel therapeutic intervention;Organoids;Osteoclasts;Outcome;overexpression;Pain;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phagocytosis;Phenotype;prevent;Process;Production;Proliferating;Proteins;PTPNS1 gene;radiological imaging;receptor;Refractory;Research;Rheumatoid Arthritis;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;symptomatic improvement;Synovial Membrane;Synovitis;T-Lymphocyte;Testing;Therapeutic;TNF gene;transcriptome sequencing;treatment strategy;Work

PROJECT_TITLE: Role of the CD47 Pathway in Rheumatoid Arthritis Pathogenesis and Treatment

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Aging

PHR: PROJECT NARRATIVE Many diseases, including Azheimer’s, Parkinson’s, and Huntington’s diseases, are caused by an abnormal accumulation of proteins, yet the pathways that degrade proteins are not fully understood. The goal of this proposal is to characterize a ubiquitin-independent protein degradation pathway that may be involved in degrading misfolded and/or oxidatively-damaged proteins. This work will provide fundamental insights into protein degradation and may lead to new methods for treating diseases caused by aberrant proteins.

PI_NAMEs: MENA, ELIJAH L (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 26S proteasome;Advisory Committees;Aging;Alzheimer's Disease;Award;base editor;Binding Sites;Biochemical;Biology;career;career development;Cell Line;Cells;Chimeric Proteins;Committee Members;Complement;CRISPR/Cas technology;Cytidine Deaminase;Defect;Degradation Pathway;Development;Disease;enhanced green fluorescent protein;Environment;Equipment;experimental study;Fluorescence-Activated Cell Sorting;Fractionation;Future;Genes;Genetic;Genetic Screening;Genomics;Goals;Homeostasis;Hospitals;Huntington Disease;Huntington gene;inhibitor;insight;Institution;Learning;Ligation;Mass Spectrum Analysis;medical schools;Mentors;Mentorship;Methods;misfolded protein;multicatalytic endopeptidase complex;Mutagenesis;mutant;Mutation;Ornithine Decarboxylase;oxidative damage;Parkinson Disease;particle;Pathway interactions;Peptide Hydrolases;Peptides;Point Mutation;Postdoctoral Fellow;Probability;Process;Proteasome Inhibition;protein degradation;Proteins;Proteomics;proteostasis;receptor;Receptor Gene;Reporter;Reporting;Research;Research Personnel;Resources;Scientist;Signal Transduction;skills;Structural Biologist;System;Techniques;Therapeutic;Training;Ubiquitin;Woman;Work

PROJECT_TITLE: Characterization of a ubiquitin-independent pathway for proteasomal degradation

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Compared to polydisperse nanoparticles, precise nanoparticles built by molecular approaches provide better reproducibility, uniformity, and more reliable quantification in biological and medical applications. The hexakisadducts of fullerene C60 make excellent structural scaffolds to build multivalent molecular nanoparticles. The proposed work will use synthetic chemistry to build a series of MRI and fluorescent probes with multiplex functional ligands, and structural precision unmatched by conventional nanoparticles.

PI_NAMEs: ZHANG, JIANYUAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Adopted;Biochemical;Biological;Biology;Biomedical Research;cancer cell;Characteristics;Chemicals;Communities;Contrast Media;covalent bond;design;Detection;Diagnostic;Diffusion;Dyes;Event;fluorescence imaging;Fluorescent Probes;fullerene C60;Fullerenes;Future;Goals;Heavy Metals;Image;imaging probe;Libraries;Ligands;live cell imaging;Magnetic Resonance Imaging;Medical;Microscopic;Molecular;nanoparticle;nanoprobe;Nature;next generation;novel;particle;Pharmaceutical Preparations;Photobleaching;Property;Quality Control;ratiometric;Reaction;Reproducibility;Research;Resistance;RNA;RNA amplification;Route;Safety;scaffold;scale up;Series;Shapes;Signal Transduction;single-molecule FRET;small molecule;Specificity;Surface;Synthesis Chemistry;Technology;Therapeutic;tool;Work

PROJECT_TITLE: A Fullerene-based Molecular Route towards Designer Nanoparticles


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative We aim to understand how a new hormone, erythroferrone, works to regulate the supply of iron for the production of red blood cells. We will also study how the dysregulation of this hormone in β-thalassemia causes iron overload and other health problems.

PI_NAMEs: GANZ, TOMAS  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Ablation;Acute;Adipose tissue;Affect;Amino Acids;Anemia;antagonist;beta Thalassemia;Binding;Biological Assay;Blood;Blood Transfusion;Bone Morphogenetic Proteins;Bone Tissue;Brain;C-terminal;Characteristics;Chronic;Development;Disease;Erythroblasts;Erythrocytes;Erythropoiesis;Erythropoietin;Extracellular Fluid;Extramedullary;Genetic Transcription;Glycoproteins;Growth;Health;Hematology;Hemoglobin;Hemorrhage;Hepatic;Hepatocyte;hepcidin;Homeostasis;Hormones;Hour;Human;Human Biology;In Vitro;in vivo;Inflammation;insight;Iron;iron absorption;iron metabolism;Iron Overload;Kidney;Ligands;Mediator;member;Metabolism;metal transporting protein 1;Modeling;Molecular;mouse model;Mus;N-terminal;neurobehavioral;novel;overexpression;Pathogenesis;Pathologic;Patients;pharmacologic;Plasma;Production;programs;Protein Family;Reporting;response;Role;Serum;Signal Transduction;Stimulus;structural determinants;Structure;Testing;thalassemia intermedia;Therapeutic;Tissues;TNF gene;Transgenes;Transgenic Mice;Transgenic Organisms;Vertebrate Biology;Work

PROJECT_TITLE: MECHANISM OF ACTION OF ERYTHROFERRONE AND PATHOLOGICAL IMPLICATIONS

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Drug compounds with a higher proportion of sp3 carbons and chiral centers tend to be more successful in the clinic, but few catalytic methods exist to perform selective late-stage dearomatizations of complex organic molecules. Heterogeneous arene hydrogenation would be an appealing method to generate six sp3 carbon centers in a single reaction, but existing catalysts suffer from poor chemo- and stereoselectivity. This proposal describes a heterogeneous substrate-directed strategy using noble metal alloy catalysts for the chemo- and stereoselective hydrogenation of arenes and hindered olefins.

PI_NAMEs: LI, CHRISTINA W (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Heterogeneous Directed Hydrogenation of Arenes and Olefins with Chemo- and Stereoselectivity


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our findings will be an important step toward elucidating the underlying biological factors that promote addiction pathology in persons with diabetes. Thus, our studies are relevant to the mission of NIH to support research aimed at reducing the burden of drug use, especially in women who are most vulnerable to the long-term health consequences of nicotine exposure.

PI_NAMEs: ODELL, LAURA ELENA (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acceleration;addiction;Address;anxiety-like behavior;behavior measurement;Behavioral;Biological Factors;Biological Markers;Bromocriptine;Bupropion;Chronic;Clinical;clinical effect;Clinical effectiveness;clinical efficacy;cohort;Dependence;Development;Diabetes Mellitus;diabetic;diabetic rat;Disease;Dopamine Agonists;Drug usage;efficacy evaluation;exenatide;experience;feeding;Female;glucagon-like peptide 1;glucophage;Goals;Health;High Fat Diet;improved;indexing;Inflammation;Insulin;Insulin Resistance;insulin signaling;Insulin-Dependent Diabetes Mellitus;Intake;Intervention;Knowledge;male;Measures;Mediator;men;Metabolic;Metabolic Diseases;Metabolic Marker;Metabolic syndrome;Mission;Modeling;negative affect;Nicotine;nicotine cessation;Nicotine Dependence;nicotine exposure;nicotine self-administration;nicotine use;Non-Insulin-Dependent Diabetes Mellitus;Pathology;Patients;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiology;Plasma;Positioning Attribute;pre-clinical;Predisposition;preference;Prevalence;Procedures;programs;Public Health;Rattus;Reduce health disparities;Regimen;Reporting;Research;Research Support;Rewards;Risk Reduction;Rodent;Rodent Model;Severities;sex;Smoking;smoking cessation;Smoking Cessation Intervention;Streptozocin;Supplementation;Testing;Time;Tobacco use;type I and type II diabetes;United States National Institutes of Health;varenicline;Vulnerable Populations;Withdrawal;Withdrawal Symptom;Woman;women versus men;Work

PROJECT_TITLE: Preventative Biomarkers and Potential Pharmacotherapies for Nicotine Use and Diabetes


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Prevention;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: UROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Lower urinary tract symptoms (LUTS) affect millions of women, with profound health, social, and economic implications. The goal of this research is to provide a deeper understanding of individual, social, and environmental risk and protective factors for LUTS development in women across the life course. Findings will be used to inform preventative strategies that will help reduce the burden of LUTS and promote bladder health in girls and women.

PI_NAMEs: RICKEY, LESLIE M. (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Adaptive Behaviors;adolescent woman;Adult women;Affect;American;Behavior;Behavioral;Behavioral Sciences;Belief;Bladder;clinical center;clinical investigation;clinical practice;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;community based participatory research;community engagement;Community Outreach;Data;Daughter;design;Development;economic implication;Ecosystem;Environment;environmental change;Environmental Risk Factor;Epidemiology;evidence base;experience;Foundations;Frequencies;Future;girls;Goals;Health;Health behavior;Health Promotion;Health Status;Healthcare;Home;Home environment;improved;Individual;innovation;Institution;Intake;Intervention Studies;Life Cycle Stages;Liquid substance;Lower urinary tract;lower urinary tract symptoms;Measurement;Measures;Methodology;Methods;Mothers;observational cohort study;Participant;Pelvic Floor Muscle;Pilot Projects;Policies;population based;Positioning Attribute;prevent;Prevention;prevention evaluation;Prevention program;Prevention Research;Prevention strategy;preventive intervention;Primary Care;Primary Prevention;protective factors;protocol development;Public Health;Publications;Research;Research Personnel;Risk Factors;school environment;Schools;Science;Scientist;Secondary Prevention;Shapes;social;social factors;social implication;Strategic Planning;symposium;Systems Theory;Time;Training;United States;Woman;Women's Health;Women's prevalence;Work

PROJECT_TITLE: Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Yale Clinical Research Center


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Periodontitis is a prevalent disease causing destruction of the tooth-supporting tissues and may adversely affect systemic health. Preliminary studies indicate that a protein expressed by periodontal tissue resident cells, designated Del-1, acts as a gatekeeper of inflammation. This project investigates the hypothesis that Del- 1 additionally promotes resolution of inflammation and restores tissue integrity, thereby paving the way to a new class of endogenous therapeutic molecules for treating periodontitis.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Address;Affect;Alveolar Bone Loss;Animal Model;Anti-Inflammatory Agents;Area;BCL6 gene;Biology;bone loss;Cells;Central Nervous System;Collaborations;cytokine;Data;Development;Disease;Dissection;Down-Regulation;Endothelial Cells;Endothelium;Fibroblasts;functional plasticity;Gatekeeping;Generations;Genetic Transcription;Germany;Health;Homeostasis;Human;IL17 gene;Immune;immune function;Immune response;Immune system;immune system function;Immunity;Inflammation;Inflammatory;inflammatory bone loss;innovation;insight;Integrins;Interleukin-1 beta;interleukin-23;Intervention Studies;Location;Lymphocyte;Macrophage;Maintenance;Modeling;Molecular;mouse model;Mouth Diseases;Multiple Sclerosis;Mus;Nature;novel;overexpression;Paper;Pathogenesis;Pennsylvania;Periodontal Diseases;Periodontitis;Periodontium;Phenotype;Pre-Clinical Model;Production;programs;Proteins;prototype;Psychiatry;Publications;reconstitution;recruit;Regulation;Research;Resolution;restoration;Science;Signal Transduction;Source;T-Lymphocyte;Testing;Therapeutic;Tissues;Tooth structure;Transcription Repressor;Transforming Growth Factor beta;Universities;Up-Regulation;Wild Type Mouse;γδ T cells

PROJECT_TITLE: Local endogenous regulators of functional immune plasticity in the periodontium


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed study will examine the short-, medium-, and long-term health, social and economic effects of the COVID-19 pandemic on an underserved and vulnerable population of young adults who have been followed since birth along with their primary caregivers who are entering middle age. Moreover, planned linkages to multilevel COVID-19 related health, social, and economic measures will be incorporated to identify how temporal and geographic variations contribute to outcomes of the two-generation sample.

PI_NAMEs: MEIER, HELEN CARMON SPINK;MITCHELL, COLTER M.S. (contact);MONK, CHRISTOPHER STEPHEN

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: 21 year old;Adult;Adult Children;Affect;African American;Age;Behavior;Behavioral;behavioral outcome;Birth;Child;Child Care;Childhood;Chronic;Cities;cohesion;cohort;Collaborations;Communities;contextual factors;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 susceptibility;Criminal Justice;Data;Data Analyses;Data Collection;Data Linkages;Economic Factors;economic outcome;Economics;emerging adult;Essential worker;ethnic minority;Family;Family health status;Family Relationship;Family Study;Future;Generations;geographic difference;Geography;Health;health economics;Health Resources;Housing;Individual;Inequality;intergenerational;Interview;Investments;Job loss;late life;Latinx;Life;Link;Living Arrangement;longitudinal analysis;Low income;Manuscripts;Measures;medical vulnerability;member;Mental Health;middle age;Neighborhoods;Occupations;offspring;Outcome;pandemic disease;pandemic potential;pandemic response;Parents;Participant;Pattern;Personal Satisfaction;physical conditioning;Policies;Population;population based;Poverty;pre-pandemic;primary caregiver;prospective;Psychological Impact;Quality of life;racial minority;racism;Recording of previous events;Reporting;Research;Resource Sharing;Resources;Respondent;response;Running;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 transmission;Security;segregation;social;Social outcome;Social support;social vulnerability;Socioeconomic Status;socioeconomics;structural determinants;Structural Racism;Surveys;transition to adulthood;transmission process;Underrepresented Populations;Underserved Population;unemployment insurance;United States;Vaccinated;Vulnerable Populations;Work;Workplace;young adult

PROJECT_TITLE: The longitudinal impact of the COVID-19 pandemic and related multi-level mitigation and contextual factors on health and socioeconomic outcomes of individuals and families from a vulnerable population


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative This project is motivated by two significant overarching problems (1) existing avenues for reading intervention in the US are not available to most children in need of help, and (2) across children there is substantial variability in pre-to-post intervention gains in reading. This project will evaluate the effectiveness of a home delivered technology-based (Edtech) reading intervention in a large and diverse sample of children, and identify factors that facilitate (or hinder) positive Edtech intervention outcomes.

PI_NAMEs: LANDI, NICOLE  (contact);MILHAM, MICHAEL PETER

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: active control;Address;Adult;Affect;Aftercare;Age;Anatomy;Area;Attention;Behavior;boys;Brain;brain based;Child;Clinical;Cognitive;comorbidity;Control Groups;cost;Country;Data;Development;Disabled Children;Disadvantaged;dosage;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;Electroencephalography;Emotional;Environment;Environmental Risk Factor;Ethics;evidence base;Family;Fostering;Functional impairment;girls;Goals;Home;Home environment;Hour;Image;Impaired cognition;Intervention;intervention effect;language impairment;Learning;Learning Disabilities;Learning Disorders;Letters;Life;Machine Learning;Magnetic Resonance Imaging;Matched Group;Mathematics;Medial;Mental Health;Meta-Analysis;Methodology;Modeling;multimodality;Nature;Neurobiology;Occupational;Outcome;Participant;participant enrollment;Patient Recruitments;Phenotype;phonology;Play;post intervention;predicting response;Prediction of Response to Therapy;Predictive Factor;predictive modeling;programs;Public Health;random forest;Randomized;Randomized, Controlled Trials;Reader;Reading;Reading Disabilities;Recommendation;remediation;Research Personnel;Resources;response;Sample Size;Sampling;School-Age Population;Schools;Services;skills;sound;Specialist;Students;Supervision;Technology;technology intervention;Time;Training;Treatment outcome;Variant;Work

PROJECT_TITLE: Effectiveness and predictors of response for a technology-based reading intervention in the home

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative Our proposed study called Addressing risk through Community Treatment for Infectious disease and Opioid use disorder Now (ACTION) among justice-involved populations, focuses on the need to improve linkage to HIV prevention and treatment and Opioid Use Disorder services for criminal justice-involved individuals by comparing the effectiveness and implementation of Patient Navigation (PN) and Mobile Health Unit (MHU) intervention models for service delivery in four highly at-risk geographic territories in Connecticut and Texas. Providing the evidence base to support effective implementation approaches that improve linkage to and engagement in integrated community services is critical to preventing new HIV infections among persons who inject drugs and those with opioid use disorders who are being released from prison and jail to the community.

PI_NAMEs: KNIGHT, KEVIN ;NIJHAWAN, ANK ELISABETH;SPRINGER, SANDRA ANN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Adherence;AIDS prevention;antiretroviral therapy;Appointment;behavioral health;care outcomes;care systems;Caring;Chlamydia;Clinic;Communities;community based service;Community Health Aides;Community Healthcare;community organizations;community reentry;Community Services;compare effectiveness;Connecticut;cost;Cost Analysis;County;Criminal Justice;Diagnosis;Disease Management;Drug Prescriptions;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness outcome;effectiveness-implementation RCT;Eligibility Determination;evidence base;follow-up;Funding;geographic risk;Harm Reduction;health care service utilization;Health Personnel;Health Services Accessibility;Hepatitis B Virus;Hepatitis C virus;high risk;HIV;HIV Infections;HIV risk;Hybrids;implementation framework;implementation outcomes;Imprisonment;improved;Incidence;Individual;infectious disease treatment;Infrastructure;Injecting drug user;injection drug use;innovation;insight;Intervention;Jail;Justice;Length;Link;London;Measures;Medical;medication for opioid use disorder;member;Methods;Mobile Health Units;Modeling;National Institute of Drug Abuse;Opioid;opioid injection;opioid use;opioid use disorder;Outcome;Overdose;Participant;patient navigation;patient navigator;peer;Persons;Pharmaceutical Preparations;Population;post intervention;pre-exposure prophylaxis;prevent;Prevention;prevention service;primary medical care;Prisons;Provider;Randomized;rapid testing;Recording of previous events;recruit;response;Risk;Risk Behaviors;satisfaction;scale up;screening;secondary outcome;service delivery;Service delivery model;service providers;Services;Sexually Transmitted Diseases;Social Environment;social stigma;Stimulant;stimulant use;Substance Use Disorder;Supervision;Syphilis;System;Testing;Texas;Time;treatment services;trial comparing;U-Series Cooperative Agreements;Use Effectiveness;Viral


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Brainstem gliomas are lethal brain tumors that represent the most common cause of brain tumor-related death in children. Radiation therapy can provide temporary relief from neurological symptoms, but despite radiation therapy the tumors eventually progress and lead to death. In this project we will investigate the mechanisms by which brainstem gliomas resist radiation therapy, which will guide the design of new treatment strategies that enhance the efficacy of radiation therapy in order to improve survival for patients with brainstem gliomas.

PI_NAMEs: REITMAN, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adult;Ataxia;Brain;Brain Neoplasms;Brain Stem;Brain Stem Glioma;cell injury;Cells;Central Nervous System Neoplasms;Cessation of life;Child;Childhood Brain Neoplasm;Classification;clinical investigation;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Credentialing;Data;design;Diffuse intrinsic pontine glioma;diffuse midline glioma;DNA Damage;driver mutation;ds-DNA;effective therapy;Enterobacteria phage P1 Cre recombinase;epigenetic therapy;Etiology;experimental study;Future;Genetic;genetic predictors;Genetically Engineered Mouse;Glioma;Goals;H3 K27M mutation;Histones;Immune;Immune response;Immune system;Immunocompetent;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;in vivo;inhibitor;Innate Immune Response;Institution;Interferon Type I;Interferons;Investigation;Ionizing radiation;LoxP-flanked allele;Maps;Mediating;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;neoplastic cell;nerve stem cell;Neurologic Symptoms;novel;novel therapeutic intervention;Oncogenes;Pathway interactions;Patients;pharmacologic;Phenotype;Population;pre-clinical;Process;Productivity;progenitor;Protein-Serine-Threonine Kinases;radiation resistance;Radiation therapy;Radiation Tolerance;Radiosensitization;rational design;recruit;reduce symptoms;Research Personnel;Resolution;response;restraint;Retroviridae;sensor;Serine;Signal Pathway;Signal Transduction;single cell genomics;stem cell population;System;Testing;Therapeutic;Time;Tissues;Treatment-related toxicity;tumor;tumor immunology;tumor microenvironment;tumor progression;Work;World Health Organization

PROJECT_TITLE: Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Disability Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: An incurable subgroup of childhood medulloblastoma are driven by N-myc, an undruggable oncogene. We hypothesize that N-myc hijacks the translational machinery regulated by the mTOR kinase to drive transformation; and that targeting translation control represents a therapeutic strategy for N-myc driven cancers. Our proposal will delineate how N-myc interacts with mTOR to regulate key subsets of translational targets, and elucidates druggable mechanisms in N-myc driven medulloblastoma.

PI_NAMEs: RUGGERO, DAVIDE ;WEISS, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 5' Untranslated Regions;Acute;Binding;Biology;Brain;cancer cell;cancer genome;Cell Death Induction;Cell Line;Cell Survival;Cessation of life;Chemotherapy and/or radiation;Child;Childhood;Childhood Malignant Brain Tumor;Childhood Medulloblastomas;Clinical;Codon Nucleotides;Cognition;cognitive disability;cohort;Complex;Cytotoxic Chemotherapy;Data;Development;Disease;Excision;FRAP1 gene;Gene Expression;Genetic;genetic approach;Genetically Engineered Mouse;Growth;Heterozygote;high risk;Human;human model;improved;in vivo;inhibitor;insight;Knockout Mice;loss of function;LoxP-flanked allele;Malignant Neoplasms;Mediating;Medulloblastoma;Membrane Proteins;Messenger RNA;Molecular;mouse model;Mus;MYCN gene;novel;novel therapeutics;Oncogenes;Oncogenic;Operative Surgical Procedures;patient stratification;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;physically handicapped;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-myc;Radiation;Regulation;Regulatory Element;Research;Resistance;Resolution;ribosome profiling;RNA;RNA Cap-Binding Proteins;RNA Helicase;Role;SHH gene;Signal Pathway;Specificity;Spinal Cord;Structure;Subgroup;Survivors;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;tool;Transcript;transcription factor;translation factor;Translations;translatome;tumor;tumorigenesis;Untranslated Regions;Xenograft procedure

PROJECT_TITLE: Remodeling the translatome in N-myc mediated medulloblastoma and its therapeutic implications

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project narrative Acute Myeloid Leukemia (AML) is an aggressive, clonally heterogeneous, myeloid malignancy and, finding a target antigen that is critical for AML biology and selectively expressed on leukemic cells is one of the foremost challenges in the emerging field of anti-AML immunotherapy. Frequently recurring mutations in genes coding for epigenetic modifiers and components of the spliceosome may generate unconventional target antigens that may arise by means of aberrant transcription, translation or post-translational modifications. Based on a novel pipeline that we called Spliced_immuneTargetFinder, we identified splice variants of cell surface proteins highly expressed in AML and we aim to investigate the relevance of these targets, opening new avenues for AML pathogenesis and treatment.

PI_NAMEs: PERNA, FABIANA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Alternative Splicing;Antibodies;Antibody-drug conjugates;Antigen Targeting;Antigens;Apoptosis;Area;Biological;Biological Assay;Biology;cancer cell;candidate validation;CAR T cell therapy;CD34 gene;Cell Fractionation;Cell Line;Cell membrane;Cell Proliferation;Cell surface;Cell Surface Proteins;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;clinical practice;Code;combinatorial;comparison control;Custom;data integration;Data Set;Development;diagnostic tool;Digestion;Disease;DNA Sequence Alteration;efficacy evaluation;Engineering;Epigenetic Process;epigenomics;Event;extracellular;Flow Cytometry;Fostering;founder mutation;Future;Genes;Genetic Transcription;Genome;Genomics;Goals;Hematopoietic Neoplasms;Hematopoietic stem cells;IL3RA gene;immune modulating agents;immunodeficiency;Immunotherapeutic agent;Immunotherapy;In Vitro;knock-down;Laboratories;Lead;lead candidate;leukemia;leukemia treatment;Leukemic Cell;leukemogenesis;loss of function;Lymphoma;Malignant Neoplasms;Messenger RNA;Methods;Modality;Molecular;Multiple Myeloma;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;new therapeutic target;NK cell therapy;Normal tissue morphology;novel;Oncogenes;Outcome;Pathogenesis;patient prognosis;Patients;Peptide Hydrolases;Phase I Clinical Trials;Post-Translational Protein Processing;protein expression;Protein Isoforms;Proteins;Proteome;Recurrence;Refractory;Relapse;RNA Splicing;Role;Safety;Sampling;selective expression;Shapes;small hairpin RNA;Solid Neoplasm;solute;Spliceosomes;SRSF2 gene;Stains;Surface;Surface Antigens;Survival Rate;Therapeutic;Therapeutic Intervention;transcriptome;transcriptome sequencing;Translations;Tumor Burden;tumor immunology;Umbilical Cord Blood;Variant;Viral;Work

PROJECT_TITLE: Alternatively spliced cell surface proteins as drivers of leukemogenesis and targets for immunotherapy


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality and although significant progress has been made in clarifying the complex pathophysiology, successful clinical translation of treatments has yet to be achieved. Our research programs have investigated the safety and effectiveness of cell transplantation strategies in people with brain and spinal cord injuries and current studies are now evaluating the use of human Schwann cell-derived exosomes to deliver anti-inflammatory and pro-regenerative mediators to the injured nervous system. We believe this novel treatment approach by targeting both neuroprotective and reparative processes will have a significant impact on the field of neurotrauma and lead to future clinical trials using this innovative therapeutic approach.

PI_NAMEs: DIETRICH, W DALTON (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Affect;amyotrophic lateral sclerosis therapy;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;axon regeneration;Ballistics;Behavioral;behavioral outcome;Biochemical;Biological Process;Blood specimen;bone repair;Brain;Brain Injuries;Brain region;CASP1 gene;Cause of Death;Cell Culture Techniques;Cell Death;Cell Therapy;Cell Transplantation;cell type;Cells;Cessation of life;Chronic;Clinic;clinical translation;Clinical Trials;clinically relevant;Complex;Cytoprotection;Data;disability;Disease;Dose;Early treatment;Effectiveness;Emergency department visit;exosome;Family Caregiver;Family member;FDA approved;Female;first-in-human;Functional disorder;functional improvement;Future;Good Manufacturing Process;Heart Arrest;Histologic;Hospitalization;Human;Human Characteristics;IL18 gene;Immune;improved;improved outcome;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Informatics;Injury;Innate Immune System;innovation;Interleukin-1 beta;intravenous administration;Investigational Drugs;Ischemic Stroke;Knowledge;Libraries;male;Measures;Mediator;Messenger RNA;MicroRNAs;miRNA expression profiling;Modality;Modeling;Molecular;Molecular Mechanisms of Action;Morbidity - disease rate;mortality;Multiprotein Complexes;myelination;Nervous System Trauma;neurite growth;Neurodegenerative Disorders;Neurological outcome;Neurons;neuroprotection;next generation;next generation sequencing;novel;Outcome;Outcome Measure;Pathologic;patient population;Pattern;Penetration;Peripheral nerve injury;Persons;Physiological;Play;Population;pre-clinical;programs;Property;protein expression;Proteins;Protocols documentation;Quality of life;regenerative;repaired;reparative process;Reporting;Reproducibility;Research;response;Role;Safety;Sampling;Schwann Cells;Series;Serum;Signal Transduction;Spinal Cord;spinal cord and brain injury;Sprague-Dawley Rats;success;targeted treatment;TBI treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;time use;transcriptome sequencing;Translating;translational potential;translational therapeutics;Translations;Traumatic Brain Injury;Treatment Protocols;treatment strategy;United States;Work

PROJECT_TITLE: Human Schwann Cell-Derived Exosome Treatment for Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  Chronic uncontrollable stress can cause or worsen many debilitating psychiatric disorders such as major depression, which often is characterized by motivational deficits and reduced engagement in activities directed toward the pursuit of goals. Dopamine plays critical roles in voluntary movement, motivation, and reward-based learning, but its precise contribution to self-initiated goal-directed behavior remains poorly understood. The proposed experiments will address this critical gap by examining the circuitry regulating dopamine during such goal-directed behavior and investigating how these circuits are altered by chronic stress.

PI_NAMEs: HOLLON, NICK GARBER (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Anatomy;Anhedonia;Animal Model;Animals;Award;Behavior;career development;Characteristics;Chronic;Chronic stress;Complex;Corpus striatum structure;Costs and Benefits;Cues;Data;Decision Making;depression model;Dopamine;dopaminergic neuron;Educational process of instructing;Electrophysiology (science);experimental study;extracellular;Foundations;Future;Goals;Impairment;in vivo;Individual;insight;Investigation;Lead;Learning;Major Depressive Disorder;Mental Depression;Mental disorders;Mental Health;Mentors;Midbrain structure;Modernization;motivated behavior;Motivation;Movement;Mus;Neuromodulator;Neurons;neuropsychiatric disorder;Neurosciences;novel;optogenetics;Outcome;outcome prediction;pars compacta;Pathway interactions;Performance;Periodicity;Phase;Physiological;Play;Population;programs;Property;Reproducibility;Research;Response to stimulus physiology;Rewards;Rodent Model;Role;Scanning;Schizophrenia;Signal Transduction;Source;Stimulus;Stress;stress related disorder;stressor;Substantia nigra structure;Symptoms;System;Technical Expertise;Techniques;Testing;tool;Training;transmission process;Update;Ventral Striatum;Ventral Tegmental Area;Viral;Withdrawal;Work

PROJECT_TITLE: Stress effects on circuitry regulating nigrostriatal dopamine during goal-directed action

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Human Fetal Tissue;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE HIV-1 trans-infection is thought to play a key role in the pathogenesis of HIV-1 infection. Direct evidence of HIV- 1 trans-infection in vivo, however, is lacking. In this this application, we propose to use novel state-of the-art approaches to ascertain whether B lymphocyte-mediated cell-to-cell HIV-1 trans-infection contributes to the establishment and replenishment of the latent viral reservoir in resting CD4+ T cells. We anticipate that this study will provide the first in vivo evidence that HIV-1 trans-infection plays a key role in viral pathogenesis.

PI_NAMEs: SLUIS-CREMER, NICOLAS PAUL (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Address;Alleles;Antigen-Presenting Cells;antiretroviral therapy;B-Cell Activation;B-Lymphocytes;Blood;BLT mice;C-Type Lectins;CCR5 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Separation;cell type;Cells;Cholesterol Homeostasis;Data;Dendritic Cells;DNA;experimental study;Genetic;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV-1;humanized mouse;In Vitro;in vivo;Individual;Infection;insight;Knowledge;latent HIV reservoir;Lymphoid Tissue;Macrophage;Mediating;MHC Class I Genes;novel;particle;Pathogenesis;peripheral blood;Phenotype;Play;Proliferating;Reporting;Resistance;Rest;Role;secondary lymphoid organ;single cell analysis;T-Lymphocyte Subsets;trait;transmission process;Viral Pathogenesis;viral rebound;Viral reservoir;viral transmission;Viremia;Virus Latency;Withdrawal

PROJECT_TITLE: Elucidating the role of B cell mediated trans infection in the establishment of the latent HIV-1 reservoir

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The development of treatment options for insulin-dependent diabetics with islet cells, which provide physiological regulation of glucose, could result in dramatic improvements in quality of life, as well as a substantial decrease in disease management complications. Herein, we seek to develop a novel encapsulation approach that serves to minimize or eliminate the need for anti-rejection therapy following an islet cell transplant, which should significantly enhance treatment options for insulin-dependent diabetics. We believe these studies are highly relevant to the mission of the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) and are designed to result in a significant impact on public health.

PI_NAMEs: STABLER, CHERIE L (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Allogenic;Allografting;Animal Model;Antibodies;Antigens;Benign;Biocompatible Materials;Biological;blood glucose regulation;capsule;CD47 gene;Cell surface;Cell Surface Proteins;Cells;Chemistry;Chronic;Clinical;clinical efficacy;clinical translation;cohort;Complex;curative treatments;design;diabetic;Diffusion;Disease Management;Distress;Encapsulated;Engineering;Engraftment;Environment;Failure;Foreign Bodies;Generations;Glucose;glucose sensor;glycemic control;Human;hypoglycemia unawareness;Hypoxia;Immune;immune modulating agents;Immune response;Immune system;Immunologics;immunoregulation;Immunosuppression;Immunosuppressive Agents;Impairment;Implant;implantation;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;Infusion procedures;Innate Immune Response;innovation;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;interest;Interleukin-10;intrahepatic;islet;Islet Cell;Islets of Langerhans Transplantation;Laboratories;Liver;Local Therapy;Malnutrition;Masks;Mission;mouse model;Mus;nanoparticle;nanoscale;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nutrient;Nutritional;Patients;Peptides;Permeability;Pharmaceutical Preparations;Phenotype;Physiological;Placenta;Polymers;Population;prevent;Proteins;prototype;Public Health;Quality of life;Reactive Oxygen Species;Replacement Therapy;response;Risk;screening;Signal Transduction;Site;Surface;Surface Antigens;synergism;System;Techniques;Testing;Therapeutic immunosuppression;therapy development;Tissues;Transforming Growth Factor beta;translational approach;Translations;Transplantation;tumor;Validation

PROJECT_TITLE: Engineering Immunomodulatory Nanoscale Coatings for Protecting Islet Transplants

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Rare Diseases

PHR: PROJECT NARRATIVE The mitochondrion generates energy for the cell and mitochondrial dysfunction is linked to a broad range of diseases, including Parkinson disease. This project will lead to the identification of small molecule probes that alter the import of proteins into the mitochondria, thereby providing new tools for characterizing the role of mitochondria in cellular homeostasis.

PI_NAMEs: KOEHLER, CARLA M (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Ataxia;Biogenesis;Biological Models;Cell Physiology;Cells;Chemicals;Complex;Data;Defect;Degenerative Disorder;Development;Dilated Cardiomyopathy;Disease;experimental study;Failure;Functional disorder;Funding;gain of function;Goals;Grant;Hereditary Spastic Paraplegia;Homeostasis;Hour;Inner mitochondrial membrane;knock-down;Knowledge;Laboratories;Lead;Link;Location;Mammalian Cell;Mammals;Membrane;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Proteins;model organism;Modeling;Mohr-Tranebjaerg syndrome;Molecular;Molecular Chaperones;muscular system;mutant;Mutation;neural;New Agents;novel;Parkinson Disease;Pathway interactions;PINK1 gene;Protein Import;Protein translocation;Proteins;Public Health;Quality Control;Research;RNA Interference;Role;Saccharomyces cerevisiae;screening;Series;Signal Transduction;small molecule;Specificity;Stress;System;Therapeutic;Tissues;tool;translocase;Work;Yeasts;Zebrafish

PROJECT_TITLE: BIOGENESIS OF THE MITOCHONDRIAL INNER MEMBRANE

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the translation of evidence-based recommendations for effective childhood obesity treatment into diverse community settings has the potential to delay or reverse the development of adult obesity, diabetes and cardiovascular disease; leading causes of morbidity and mortality in the US today. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to application of knowledge to enhance health, lengthen life, and reduce illness and disability. In addition, the research is relevant to the NICHD’s mission to enhance the lives and optimize abilities for all children.

PI_NAMEs: ARMSTRONG, SARAH C;SKINNER, ASHELEY COCKRELL (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: adopted child;Adult;adult obesity;Body mass index;Cardiovascular Diseases;cardiovascular health;Caregivers;Caring;Characteristics;Child;Child health care;Childhood;Chronic Disease;Clinic;Clinical;clinical practice;Communities;community setting;comorbidity;cost;Data;design;Development;Diabetes Mellitus;disability;Disease;dissemination strategy;effective therapy;Effectiveness;Ensure;Environment;Epidemic;evidence based guidelines;Evidence based treatment;Family;Funding;Future;Generations;Goals;Habits;Hand;Health;Health Benefit;Health Care Reform;Hour;implementation evaluation;implementation outcomes;implementation process;implementation strategy;implementation tool;Improve Access;improved;innovation;Interruption;Intervention;Knowledge;Lead;learning materials;Life;Life Expectancy;Life Style Modification;Location;Low income;Measures;Minority;Mission;Modeling;Morbidity - disease rate;mortality;Municipalities;National Institute of Child Health and Human Development;Obesity;Obesity associated cancer;Obesity Epidemic;obesity in children;obesity treatment;Online Systems;Outcome;Overweight;Parents;payment;pediatrician;Pediatrics;Physical Fitness;Population;prevent;Primary Care;Process;programs;Provider;Public Health;Quality of life;Recommendation;Recording of previous events;Recreation;Reporting;Research;Resource-limited setting;Resources;Risk;Risk Reduction;Rural;Series;Site;Testing;Time;Training Activity;Translating;Translations;United States;United States National Institutes of Health;United States Preventative Services Task Force;uptake;web platform;Work

PROJECT_TITLE: Parks & Pediatrics Fit Together: Translating knowledge into action for child obesity treatment in partnership with Parks and Recreation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Recovery Support Services;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The COVID-19 pandemic puts individuals recovering from opioid use disorders (OUDs), an already vulnerable population, at increased risk of overdose due to decreased access to treatment, decreased social support, and increased psychosocial stress. This proposal will test the efficacy of a promising mobile app-based peer support program, compared to usual care, in increasing recovery capital, improving retention in treatment, and reducing psychosocial adverse effects, among a national sample of people in recovery from OUD. If effective, it would provide an accessible, personalized, and scalable approach to OUD recovery increasingly needed during the COVID-19 pandemic.

PI_NAMEs: BEAUDOIN, FRANCESCA  (contact);RANNEY, MEGAN LARIN

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;administrative database;Adult;Adverse effects;Adverse event;Advertisements;Ambulatory Care;American;Anxiety;barrier to care;Behavior Therapy;Buprenorphine;Capital;Cellular Phone;clinically relevant;Collaborations;Communities;comparison control;Control Groups;County;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Set;Dedications;density;depressive symptoms;digital health;Distress;Drug usage;Education;efficacy outcomes;efficacy study;efficacy testing;Electronic Health Record;Emergency department visit;Enrollment;Ethics;ethnic minority;Ethnic Origin;evidence base;Evidence based treatment;Exclusion;experience;Facebook;follow-up;Geography;Grant;Health;Health Services Accessibility;Home;improved;Incidence;Income;Indiana;Individual;Intervention;Intervention Studies;Loneliness;Low income;low socioeconomic status;Measures;medication for opioid use disorder;Methods;Minority Groups;mobile application;Natural Language Processing;novel;opioid overdose;opioid use disorder;Outcome;overdose risk;pandemic disease;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;peer;peer recovery;peer support;Persons;prevent;primary endpoint;primary outcome;Process;programs;psychosocial;Psychosocial Stress;Public Health;Quality of life;Race;racial minority;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recovery services;Recovery Support;recruit;Recurrence;Regulation;Reporting;Research;Resources;response;Rhode Island;Rural;rural area;Sampling;secondary endpoint;secondary outcome;Secure;Security;Self Efficacy;Self-Injurious Behavior;Services;social;Social Distance;social group;social media;social stigma;Social support;Socioeconomic Status;Stress;Structure;substance use;Support Groups;System;Testing;Text;Time;tool;treatment as usual;treatment program;Treatment/Psychosocial Effects;United States;Validation;Vulnerable Populations

PROJECT_TITLE: Increasing Peer Support for OUD Recovery during COVID-19 through Digital Health: A National Randomized Controlled Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Heart failure and cardiac arrhythmias affect millions of Americans. Ca-Calmodulin dependent protein kinase II (CaMKII) has been shown to regulate the function of numerous ion channels and calcium transporters in cardiac myocytes that govern normal excitability and contraction. CaMKII is known to be upregulated and chronically activated in multiple chronic cardiovascular diseases including, and has been implicated in the development of heart failure and arrhythmias. We will elucidate the actual molecular mechanisms that individually cause chronic CaMKII activation, limit CaMKII activation, study how these functionally synergize, and how a novel regulation by S- nitrosylation may be critical to the hearts intrinsic ability to adapt to increased afterload, and how CaMKII may play differential roles in two different models of heart failure with preserved ejection fraction.

PI_NAMEs: BERS, DONALD M (contact);BOSSUYT, JULIE B

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Adult;Affect;Affinity;American;Animals;Arrhythmia;Binding;Binding Sites;Biochemistry;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcineurin;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cells;Chronic;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Development;Diabetes Mellitus;diabetic;EFRAC;Failure;falls;Fatty acid glycerol esters;Fluorescence Resonance Energy Transfer;Functional disorder;Gel;Gene Expression;Genetic;Genetic Transcription;Heart;Heart failure;heart function;Histone Deacetylase;Homeostasis;Hyperglycemia;Image;indium arsenide;Individual;innovation;Ion Channel;Ions;Knock-in Mouse;Knowledge;Link;Measures;Mediating;Memory;Metabolism;Methylation;Microfilaments;Modeling;Molecular;Molecular Conformation;Muscle Cells;mutant;Mutation;Neurons;NG-Nitroarginine Methyl Ester;Nitric Oxide Synthase;novel;Nuclear;oxidation;Pathologic;Pathology;Patients;Phenotype;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;preservation;pressure;prevent;Process;Production;Proteins;Regulation;Reporter;Resistance;response;Role;Site;synergism;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transducers

PROJECT_TITLE: CaMKII activation and regulation in adult cardiac myocytes

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: Project Narrative DNA methylation is an epigenetic mark crucial for maintaining transcriptional states and aberrant DNA methylation patterns are a hallmark of cancer and other diseases. This research will decipher how DNA methylation patterns are dynamically maintained from the cellular to generational scales, determine the function of DNA demethylation during somatic and reproductive development, and identify the mechanisms underlying imprinted gene expression. The research will lead to new understanding of how these processes are modulated during normal growth and development and how they are potentially altered in disease states.

PI_NAMEs: GEHRING, MARY  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aberrant DNA Methylation;Address;Arabidopsis;Area;Biological Models;Cells;Code;comparative;cost;demethylation;Development;Disease;DNA;DNA glycosylase;DNA Methylation;DNA Modification Methylases;DNA Transposable Elements;Embryo;Epigenetic Process;epigenome;Eukaryota;Female;Fertilization;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genomic Imprinting;Genomics;Germ Cells;Growth and Development function;Heritability;Homeostasis;imprint;Laboratories;Malignant Neoplasms;Methylation;methylation pattern;Modification;Mouse-ear Cress;neuronal cell body;Pathway interactions;Placenta;prevent;Process;Proliferating;Proteins;Regulation;Repression;Reproduction;reproductive development;Research;response;System;Time;Tissues

PROJECT_TITLE: Function and Mechanisms of Epigenetic Stability and Dynamics in Arabidopsis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE In salt sensitive (SS) hypertension, an increase in dietary salt intake causes an elevation in blood pressure, which largely happens due to a pathological inability of the kidneys to get rid of the salt. Existing hypertension treatment strategies are often ineffective for salt-sensitive people. This proposal is focused on the renal mechanisms of salt-sensitive hypertension development. Specifically, we will look into mitochondria function and energy metabolism regulated by a crucial hormone (atrial natriuretic peptide), that is known to be decreased in SS individuals. We will seek novel mitochondria-related targets for the treatment of this disease.

PI_NAMEs: ILATOVSKAYA, DARIA  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: absorption;Acute;Address;Adipose tissue;Affect;Animal Model;Animals;Antioxidants;Atrial Natriuretic Factor;Attenuated;attenuation;Bioenergetics;Biogenesis;blood flow measurement;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;blood pressure reduction;Cells;cGMP production;Chronic;Clinic;Clinical Data;Cultured Cells;Cyclic GMP;Data;Defect;design;Development;dietary salt;Disease;Diuresis;Duct (organ) structure;Echocardiography;effective therapy;Electrophysiology (science);Energy Metabolism;epithelial Na+ channel;Equilibrium;Event;Excretory function;Exhibits;Experimental Designs;Free Radical Formation;Functional disorder;Generations;Heart failure;heart function;Heterozygote;high risk;Hormones;Hydrogen Peroxide;Hypertension;hypertension treatment;hypertensive;Image;Impairment;improved;in vivo;Individual;Infusion procedures;Injury to Kidney;Kidney;Knock-out;Knowledge;Link;Location;Measurement;Mediating;Metabolic;metabolic abnormality assessment;Microscopy;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Biology;Muscle;Natriuretic Peptides;Nephrons;novel;Organ;patch clamp;Pathologic;Pathway interactions;patient subsets;Peptide Signal Sequences;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Production;Rattus;Reactive Oxygen Species;receptor sensitivity;recruit;Regulation;Renal Blood Flow;renal damage;Renal Tissue;Resistance;Respiration;salt intake;salt sensitive;salt sensitive hypertension;Sodium;Sodium Chloride;Spin Trapping;Spirometry;Superoxides;TAC1 gene;Techniques;Testing;Therapeutic;Therapeutic Effect;Tissues;treatment strategy;Vasodilation

PROJECT_TITLE: Mitochondria-mediated effects and therapeutic potential of Atrial Natriuretic Peptide in salt-sensitive hypertension

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Prevention;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Chronic kidney disease of uncertain or unknown etiology is a life-threatening condition that affects a growing number of individuals in geographically diverse regions around the world. The National Institutes of Health has formed the Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium to better understand the causes, progression, potential treatments, and interventions for this debilitating disease. RTI International and Boston University propose to jointly establish the CURE Research Consortium Scientific Data Coordinating Center and provide the infrastructure and expertise to enable this Consortium to develop and field the CURE Study in several CKDu endemic regions.

PI_NAMEs: BROOKS, DANIEL R;LEBOV, JILL  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Affect;Agreement;agricultural community;analytical method;Asia;Behavioral;biobank;Biological;Biological Markers;Biometry;Biopsy Specimen;Boston;case control;Case/Control Studies;Central America;Central Asia;Chronic Kidney Failure;Clinical;Clinical Treatment;cohort;Collaborations;Colorado;Communication;Communities;community research;Consensus;Coordination and Collaboration;Data;Data Analyses;Data Collection;Data Coordinating Center;data dissemination;Data Reporting;Data Science;data tools;data visualization;Decision Making;Development;Diabetes Mellitus;Disease;Disease Progression;disorder control;Doctor of Philosophy;El Salvador;electronic data capture system;Eligibility Determination;Enrollment;Ensure;Environmental Health;Environmental Monitoring;Environmental Pollutants;Environmental Risk Factor;Epidemiologic Research Design;Epidemiologist;Epidemiology;epidemiology study;Equipment;Ethics;Etiology;experience;Family;follow-up;Fostering;Generations;Genetic;Genetic Determinism;Geography;Health;Healthcare Systems;Human;human subject protection;Hypertension;India;Individual;Infection;Infrastructure;interest;International;Intervention;Kidney;kidney biopsy;Kidney Diseases;kidney dysfunction;Laboratories;Lead;Leadership;Life;local economy;Longitudinal Studies;Management Information Systems;Manuals;Medical;meetings;men;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Nephrology;Nicaragua;novel;Occupational;Occupational Health;Outcome;Pathway interactions;Patients;Policies;Principal Investigator;Privatization;Procedures;Productivity;programs;Protocols documentation;public health intervention;Questionnaires;Recording of previous events;Reporting;Research;Research Design;Research Personnel;research study;Research Support;research vision;Resource-limited setting;Resources;Risk;Risk Factors;Risk Reduction;Role;sample collection;Science;Services;Shipping;Site;sound;Specific qualifier value;Specimen;Sri Lanka;System;Technology;therapeutic target;tool;Training;United States National Institutes of Health;Universities;Variant;Visualization software;web site;Work

PROJECT_TITLE: Chronic Kidney Diseases of Uncertain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - SDCC


ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: NARRATIVE The transcription factor p53 is a central regulator of genome fidelity through its control of a complex gene regulatory network that restrains cell proliferation after DNA damage. The inability to properly respond to DNA damage severely reduces organismal fitness and leads to a number of deleterious human disorders, such as premature aging, cancer, neuro-developmental diseases, and infertility. Further, multiple therapeutic approaches currently in development, including stem cell reprogramming and genome editing strategies, are strongly inhibited by the p53 pathway, and recent evidence suggests that many “successful” stem cell reprogramming events actually have accidentally inactivated this key checkpoint. Therefore, a vigorous examination of the complex gene networks controlled by p53 is timely and prudent. Ultimately, this work will launch a long-term research program focused on investigation into the molecular mechanisms underlying transcription factor regulation of cell fate decisions and human disease.

PI_NAMEs: SAMMONS, MORGAN ANDREW (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 3-Dimensional;Accidents;Aging;biochemical model;biological adaptation to stress;Cell Fate Control;Cell Proliferation;Cell Reprogramming;Cell Therapy;Cells;Chromatin Structure;combinatorial;Complex;Development;Disease;DNA Damage;Engineering;Epigenetic Process;Event;Exposure to;fitness;Funding;gene network;gene regulatory network;Genetic;Genetic Models;Genetic Transcription;Genome;genome editing;Genomics;Goals;Homeostasis;Human;Human Development;human disease;Infertility;insight;Investigation;Malignant Neoplasms;Maps;Molecular;Neurodevelopmental Disorder;novel;Pathway interactions;Premature aging syndrome;preservation;programs;Regulatory Element;Research;response;restraint;stem cells;Structure;Therapeutic;TP53 gene;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Defining cis-regulatory networks controlling a core stress response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: PATHOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed work will test entirely novel approaches to achieve HIV-1 remission in infants and children affected by the global HIV-1 pandemic. A proven animal model of vertical HIV-1 infection in primates will be used to study a novel combined treatment of drugs, infection-blocking antibodies, and HIV-directed antibodies with the potential to reduce disease severity or clear infection, so that children will not need lifelong treatment. These clinical strategies could be adapted for addressing pediatric HIV-1 infection worldwide.

PI_NAMEs: HAIGWOOD, NANCY L (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acute;Address;Adult;Affect;Aftercare;Animal Model;Anti-Retroviral Agents;Antibodies;antibody engineering;Antibody Therapy;Binding;Biodistribution;Biological Assay;Birth;Blocking Antibodies;Blood;Breast Feeding;CCR5 gene;Cells;Child;Clinic;Clinical;Combined Modality Therapy;design;Disease remission;Dose;experience;experimental study;Exposure to;Goals;Grant;Health;HIV;HIV-1;Hour;Human;human monoclonal antibodies;Image;Immunity;in utero;in vivo imaging;Infant;infant infection;Infection;infection risk;insight;Interruption;Length;Macaca;Macaca mulatta;Maternal antibody;Maternal-Fetal Transmission;Memory;Modality;Modeling;Monitor;Monoclonal Antibodies;mother nutrition;Mothers;neutralizing monoclonal antibodies;Newborn Infant;nonhuman primate;novel;novel strategies;novel therapeutics;Oral;pandemic disease;Pathogenicity;pediatric human immunodeficiency virus;Perinatal;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;pre-exposure prophylaxis;prevent;Prevention;Primates;prophylactic;Prophylactic treatment;Regimen;Reproducibility;research clinical testing;Research Design;Research Proposals;Residual state;Risk;risk mitigation;Route;Safety;Satellite Viruses;Sequential Treatment;Severity of illness;simian human immunodeficiency virus;standard of care;subcutaneous;Testing;Therapeutic;Therapeutic antibodies;therapeutic effectiveness;therapy development;Time;Tissues;Translations;Vertical Transmission;Viral;viral rebound;Viral reservoir;Viremia;Virus;Virus Diseases;Virus Latency;Visualization;Withholding Treatment;Work

PROJECT_TITLE: Reducing Latent Viral Reservoirs in Infant Macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rehabilitation;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: This study focuses on delivering a smoking cessation induction intervention during and after dental patients’ teeth cleaning, providing access to smokers who may not otherwise seek treatment for smoking cessation. This is critical for public health, because the majority of current smokers are not ready to quit smoking. Because the intervention is video-and text message based, it is appropriate for low literacy and underserved populations, and could easily be disseminated to other dental clinics with minimal provider and patient burden.

PI_NAMEs: BORRELLI, BELINDA  (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Abstinence;Affect;Appointment;automated text message;Biochemical;Client satisfaction;Clinic;clinical care;Clinical Practice Guideline;Cognitive;Control Groups;cost effective;Counseling;Data;Dental;Dental Clinics;Dental Implants;Depressed mood;Education;Effectiveness;efficacy testing;efficacy trial;Environment;Ethnic Origin;evidence base;Evidence based treatment;experience;Failure;follow up assessment;follow-up;Gender;General Population;Gingival Recession;healing;Health;Impairment;innovation;instrument;Intervention;intervention effect;Intervention Studies;Interview;Lesion;literacy;live text;Logistics;Low income;low socioeconomic status;Measures;Mediator;Motivation;mouth squamous cell carcinoma;Mucous Membrane;nicotine replacement;operation;Oral health;Pamphlets;Participant;patient-clinician communication;Patients;Periodontal Diseases;Pharmaceutical Preparations;Phase;Pilot Projects;premalignant;prevent;Printing;Procedures;programs;Provider;Public Health;quitline;Race;Randomized;Readiness;Relaxation;Relaxation Techniques;Reporting;Research;Research Support;Resources;Role;satisfaction;Schedule;secondary outcome;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social;Subgroup;tailored text messaging;Technology;Telephone;Testing;Text;Text Messaging;Time;Time Management;Tooth structure;Training;treatment effect;Underserved Population;usability;virtual reality;virtual reality headset;virtual reality intervention;Work

PROJECT_TITLE: Delivery of a Smoking Cessation Induction Intervention Via Virtual Reality Headset During a Dental Cleaning