NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: DE MARZO, ANGELO MICHAEL (contact)

PROJECT_TERMS: Achievement;Algorithms;Autopsy;Biological Markers;biomarker validation;Biopsy;Catalogs;Cell Line;cell type;Cells;Clinical;Collaborations;Country;Data Set;Databases;design;Diagnosis;digital;DNA;Family;follow-up;Freezing;Genetic;Genitourinary system;Genomics;Goals;Human;Image Analysis;Immunofluorescence Immunologic;Immunooncology;improved;In Situ Hybridization;Individual;Inflammatory;Informatics;Institution;laboratory development;laser capture microdissection;Link;Liquid substance;Malignant neoplasm of prostate;Measures;Metastatic Prostate Cancer;Methods;neoplastic;new technology;Oncology;operation;Paraffin Tissue;Pathologic;Pathology;Preparation;Procedures;programs;Prostate;Prostatic;protein profiling;Proteins;Protocols documentation;quality assurance;Quality Control;quantitative imaging;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;RNA;Sampling;Science;Slide;Specimen;Stains;Standardization;Technology;technology development;Testing;Tissue Microarray;Tissues;tool;Translational Research;tumor;United States National Institutes of Health;validation studies;Xenograft procedure

PROJECT_TITLE: Biospecimen Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: WANG, HAO  (contact)

PROJECT_TERMS: Address;Adherence;Area;Basic Science;Bioinformatics;Biometry;Biostatistics Core;Cancer Center Support Grant;career;career development;Clinical Trials;cohort;Collaborations;Collection;Complex;Comprehensive Cancer Center;Consultations;Data;Data Analyses;Data Collection;Data Linkages;data management;data quality;Data Reporting;data visualization;Databases;Dedications;design;Development;Ensure;Epidemiologist;Epidemiology;epidemiology study;experience;Funding;Human Resources;human subject;Informatics;Institution;Investigation;Knowledge;Malignant neoplasm of prostate;meetings;member;Methodology;Methods;Modeling;Monitor;Monitoring Clinical Trials;novel;operation;Pathology;Peer Review;Philosophy;Play;Population;Positioning Attribute;Process;Program Development;programs;Prostate;Protocols documentation;Publications;quality assurance;Quality Control;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Review Committee;Role;Safety;Sample Size;Specific qualifier value;Specimen;synergism;Tissue Banks;Toxic effect;Translating;Translational Research;Visualization;Work;working group

PROJECT_TITLE: Biostatistics Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-8 (O1)]


PI_NAMEs: LUO, JUN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Appointment;Award;Collaborations;Communication;Community Participation;Data;Development;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;Funding;Grant;Institution;Intention;Malignant neoplasm of prostate;Medical;meetings;Mentors;novel;Pilot Projects;Productivity;programs;Recommendation;Research;Research Project Grants;Testing;translational impact;translational potential;United States National Institutes of Health;Wages

PROJECT_TITLE: Developmental Research Program


PI_NAMEs: PLATZ, ELIZABETH A. (contact)

PROJECT_TERMS: Address;anti-cancer research;Appointment;Area;career;career development;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;Faculty;Funding;Goals;Grant;Institution;Malignant neoplasm of prostate;Medical;Mentors;Productivity;programs;Research;Research Personnel;Translational Research

PROJECT_TITLE: Career Enhancement Program


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT SUMMARY/ABSTRACT The Laura and Isaac Perlmutter Cancer Center (PCC) is a matrix cancer center that oversees and directs all cancer research and care in the NYU Langone Health (NYULH) system. Our 195 Members engage in basic, translational, clinical, and/or population research to address the needs of our large, diverse catchment area.

PI_NAMEs: KIMMELMAN, ALEC  (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Basic Science;bench to bedside;Biology;Cancer Biology;Cancer Burden;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer epidemiology;cancer genetics;cancer genome;cancer health disparity;Cancer Patient;cancer therapy;cancer type;Caring;Catchment Area;Cellular biology;Childhood Leukemia;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Correlative Study;County;COVID-19;COVID-19 pandemic;Dana-Farber Cancer Institute;Disease;Disparity;Early Therapeutic-Clinical Trials Network;Education;Environmental Pollutants;Epidemiology;Epigenetic Process;frontier;Funding;Genome;Genomics;Goals;graduate student;Grant;Growth;Health;Health system;High School Student;Home;House Staffs;Immunology;Immunotherapy;improved;infection related cancer;Influentials;innovation;insight;Institution;inter-institutional;interest;Journals;junior high school;Laboratories;Laboratory Scientists;Lead;Leadership;Licensing;Long Island;Lymphoma;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;medical schools;Medical Students;Medicine;Melanoma;member;Mentorship;Metabolism;New York;next generation;novel therapeutics;Nursing Students;Obesity;outcome disparities;Outcomes Research;Pathway interactions;Patient Care;patient oriented;Patients;Peer Review;Phase;Policies;Population;Population Research;Population Sciences;prevent;programs;Public Policy;public policy on tobacco;Publications;recruit;Research;Research Personnel;Resource Sharing;Schools;Science;Scientist;Signal Transduction;Strategic Planning;targeted therapy trials;Thinking;Time;tobacco control;Training;Training and Education;Translating;Translational Research;tumor immunology;undergraduate student;Underrepresented Minority;Universities

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: STRAWDERMAN, TIM  (contact)

PROJECT_TERMS: Accountability;Appointment;Attention;Basic Science;Cancer Center;Cancer Center Support Grant;Clinical Research;Clinical Trials;Communication;Communities;Community Health Education;Community Outreach;Complex;Comprehensive Cancer Center;Data;Development;Ensure;equity, diversity, and inclusion;Faculty;Financial Support;Funding;Funding Opportunities;Goals;Health system;Hematology;Informatics;Information Systems;Institution;Maintenance;Malignant Neoplasms;meetings;member;New York City;Nursing Faculty;Oncology;operation;Organizational Objectives;Patients;Play;Population Research;Process;programs;recruit;Reporting;research faculty;Resource Sharing;Resources;Role;Strategic Planning;Students;success;symposium;Training and Education;Translational Research;user-friendly

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: PHILIPS, MARK REID (contact)

PROJECT_TERMS: Academic Medical Centers;Advisory Committees;anti-cancer research;Bioinformatics;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer education;cancer prevention;career;career development;Caring;Charge;Clinical;clinical conference;Clinical Nursing Research;clinical translation;continuing medical education;data science education;Degree program;Dentistry;Discipline of Nursing;diversity and inclusion;Doctor of Philosophy;Education;Educational Activities;Educational Curriculum;Educational process of instructing;Engineering;Ensure;Entrepreneurship;Event;Faculty;faculty mentor;faculty research;Fellowship;Funding;Future;global health;Goals;Graduate Education;Grant;Gynecologic Oncology;Health;Health Professional;high school;Home;Infrastructure;innovation;International;junior high school;Laboratories;Leadership;Malignant Neoplasms;Medical;Medical Education;Medical Oncology;medical schools;Medical Students;meetings;member;Mentors;Methods;Middle School Student;Mission;Monitor;NCI Center for Cancer Research;New York;New York City;next generation;Nursing Research;Oncology;outreach;outreach program;Patient Care;Pediatric Oncology;Play;Population;Postdoctoral Fellow;Prevention;Process;programs;Radiation Oncology;ras Oncogene;Recording of previous events;recruit;Research;Research Personnel;Residencies;Resources;Role;Science;Scientist;Series;Social Work;Students;success;Surgical Oncology;symposium;Training;Training and Education;Training Programs;Translational Research;Travel;undergraduate student;Underrepresented Minority;underrepresented minority student;United States;United States National Institutes of Health;university student;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: RAVENELL, JOSEPH E (contact)

PROJECT_TERMS: Administrator;Advisory Committees;anti-cancer research;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;Cancer Science;cancer therapy;care providers;Caring;Catchment Area;Clinical;cohort;Communities;community collaboration;community engagement;Community Outreach;Creativeness;disparity elimination;diversity and inclusion;Ensure;Environment;equity, diversity, and inclusion;Faculty;Fostering;Future;Goals;Gynecologic Oncology;Health;health disparity;health equity;Health system;House Staffs;Individual;Institution;interest;Knowledge;Leadership;Measurable;medical schools;Medicine;member;Mentors;Mentorship;mid-career faculty;Mission;Monitor;Morals;next generation;outreach;patient oriented;Patients;population health;Population Heterogeneity;Positioning Attribute;profession allied to medicine;recruit;Research;Research Personnel;Role;skills;student training;Students;synergism;Talents;Training;Training and Education;Underrepresented Populations

PROJECT_TITLE: Plan to Enhance Diversity


PI_NAMEs: KLEIN, HANNAH L. (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Air Pollution;Aneuploidy;Architecture;Basic Science;bench to bedside;Bioinformatics;Biophotonics;Black race;Brain Neoplasms;Cancer Biology;Cancer Burden;Cancer Center Support Grant;cancer genome;carcinogenicity;Catchment Area;Cell Cycle;chromatin modification;Chromosome Segregation;Chromosome Structures;Chromosomes;CLIA certified;Clinic;Clinical;clinical investigation;Clinical Investigator;clinical sequencing;Clinical Trials;cohesin;Collaborations;community engagement;Community Outreach;computational pipelines;Country;Custom;Defect;design;diagnostic technologies;Disease;Disease Management;Disparity;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Repair;DNA Sequence;Doctor of Philosophy;drug discovery;Environmental Carcinogens;Enzymes;Epigenetic Process;epigenetic regulation;Evolution;Faculty;Faith;FDA approved;Funding;Future;Gene Expression Regulation;Genes;Genetic;genetic testing;Genetic Transcription;Genome;genome integrity;genomic profiling;Goals;Histones;Home;humanized mouse;Immune;innovation;insight;Intellectual Property;inter-institutional;Intervention;Investigation;Journals;Laboratories;Laboratory Scientists;Laboratory Study;Legal patent;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;medical schools;meetings;member;Metals;Microscopy;mid-career faculty;Mission;Molecular;Molecular Genetics;molecular pathology;mouse model;Multiple Myeloma;Mutation;novel;novel anticancer drug;novel therapeutics;Oncogenic;Output;Paper;Patients;Play;Population;Prevention strategy;professor;programs;Proteins;Publications;Publishing;repaired;Research;research and development;Research Personnel;Resource Sharing;Retrotransposon;Role;single molecule;Single Nucleotide Polymorphism;Smoking;Somatic Mutation;synthetic construct;targeted cancer therapy;Technology;telomere;Testing;transcription factor;Translating;Translations;treatment response;tumor;tumor diagnosis;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;whole genome;World Trade Center disaster

PROJECT_TITLE: Cancer Genome Dynamics (CGD) Research Program


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Precision Medicine;Prostate Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: POSSEMATO, RICHARD LEWIS (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer;Antibodies;Area;Autophagocytosis;bench to bedside;Biochemical Pathway;Bioinformatics;Biological Markers;Biological Products;Biology;Biotechnology;BRAF gene;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer subtypes;Catchment Area;Cell Physiology;Cellular biology;Chemicals;Chemistry;Chest;Clinic;Clinical;Clinical Investigator;Clinical Trials;Clinical Trials Unit;cofactor;college;Colon;community engagement;Community Outreach;Dentistry;Dependence;design;Disparity;Doctor of Philosophy;drug candidate;Experimental Pathology;Funding;Genes;Genetic;Genome;Grant;Home;host neoplasm interaction;Human;improved;innovation;insight;inter-institutional;interest;Investments;Iron;Journals;KRAS2 gene;Laboratories;Lead;Leadership;Legal patent;Licensing;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncology;medical schools;Medicine;meetings;Melanoma;member;Metabolic;Metabolism;metabolomics;Microscopy;mid-career faculty;Mission;Molecular;Molecular Target;multi-site trial;multidisciplinary;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Oncogenes;Oncogenic;palmitoylation;Pancreas;Pancreatic Adenocarcinoma;Paper;Pathology;Pathway interactions;patient response;patient stratification;Patients;Peer Review;personalized cancer therapy;personalized medicine;pharmacologic;Phase I Clinical Trials;Phosphorylation;Physician Executives;Physicians;PIK3CG gene;Post-Translational Protein Processing;preclinical development;Prediction of Response to Therapy;prenylation;Productivity;professor;programs;Property;Prostate;Protein Engineering;Proteomics;Proteomics Shared Resource;Publications;Publishing;Radiation Oncology;Reactive Oxygen Species;recruit;Research;research and development;Research Personnel;Resistance;Resource Sharing;response biomarker;Science;Seminal;Signal Transduction;Site;small molecule inhibitor;Structure;synthetic lethal interaction;Technology;Testing;Therapeutic;Therapeutic Uses;Training Programs;Training Support;Translating;translational pipeline;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Cancer Cell Biology (CCB) Research Program


PI_NAMEs: KROGSGAARD, MICHELLE  (contact)

PROJECT_TERMS: Animal Model;anti-tumor immune response;Antigens;Area;Arts;B-Lymphocytes;Basic Science;Bioinformatics;Cancer Biology;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Patient;cancer therapy;cancer type;Cancer Vaccines;Catchment Area;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;college;Color;Communication;community engagement;Community Outreach;Complex;Conduct Clinical Trials;Dendritic Cells;Dentistry;design;Development;Direct Costs;Disease;Disease Management;Disparity;Doctor of Philosophy;early phase clinical trial;Effectiveness;Engineering;Enhancement Technology;exhaust;Experimental Pathology;Flow Cytometry;Funding;Future;Genetic Engineering;Genome;Goals;Grant;gut microbiome;Hematologic Neoplasms;high dimensionality;Immune;Immune response;Immune system;Immunohistochemistry;Immunologic Monitoring;Immunologics;Immunologist;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;innovation;innovative technologies;insight;Institution;inter-institutional;Intervention;investigator-initiated trial;Journals;Knowledge;Laboratories;Legal patent;Licensing;Lymphatic;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuscripts;medical schools;meetings;Melanoma;member;Methodology;microbiome;Mission;Molecular;mouse model;Natural Killer Cells;neutrophil;novel;novel therapeutics;Organoids;Outcome;Paper;Patients;peripheral blood;Physicians;pre-clinical;Pre-Clinical Model;preclinical imaging;predictive marker;Prognostic Marker;programs;Publications;Publishing;recruit;Regulatory T-Lymphocyte;Research;research and development;Research Design;Research Personnel;Resource Sharing;response;Rodent;Role;Schools;Science;Scientist;Seminal;single-cell RNA sequencing;Specimen;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;trafficking;transcriptomics;Transgenic Mice;Translating;Translational Research;Translations;treatment response;tumor;Tumor Escape;Tumor Immunity;tumor immunology;tumor microbiome;tumor microenvironment;Work

PROJECT_TITLE: Tumor Immunology (TIM) Research Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Lung Cancer;Microbiome;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: AHN, JIYOUNG  (contact)

PROJECT_TERMS: Academia;Affect;Air Pollution;ambient air pollution;Area;Attention;Basic Science;Behavior;Behavioral;Biostatistics Shared Resource;Breast Cancer Patient;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research Program;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;care delivery;Caring;Catchment Area;Clinical Trials;cohort;Collaborations;college;Communities;community engagement;Community Outreach;Complex;Continuity of Patient Care;Dentistry;Direct Costs;Discipline of Nursing;Disease;disease prognosis;Disparate;diversity and equity;Doctor of Philosophy;early detection biomarkers;Early Diagnosis;Early identification;early screening;Epidemiologic Factors;Epidemiology;equity, diversity, and inclusion;Faculty;follow-up;Funding;Future;Gastrointestinal tract structure;genetic risk factor;Goals;Grant;Growth;Guidelines;Health Policy;Health Services Research;Helicobacter pylori;Human Genetics;Human Microbiome;Human Papillomavirus;Image;implementation science;improved;Incidence;Industry;Infrastructure;innovation;inter-institutional;Intervention;Intervention Trial;Journals;Knowledge;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;member;Methods;Microbe;microbial;microbiome;Mission;Monitor;multi-ethnic;NCI Center for Cancer Research;New York City;novel;Obesity;Observational Study;Oncology;Outcome;outcome disparities;Pain management;Paper;Participant;pathogen;Pediatrics;Peer Review;Population;population health;Population Heterogeneity;Population Research;programs;Public Health;Publications;Publishing;recruit;Research;Research Infrastructure;Research Personnel;Resources;Risk;Risk Factors;risk prediction model;Science;screening;Screening for cancer;Services;Smoking;Strategic Planning;synergism;Testing;tobacco control;tobacco products;Tobacco-Related Carcinoma;Translating;Translations;trend;urban setting;Validation;Vision;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Epidemiology & Cancer Control (ECC) Research Program


NIH_SPENDING_CATS: Breast Cancer;Burden of Illness;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: TRINH-SHEVRIN, CHAU  (contact)

PROJECT_TERMS: Address;Area;Asian;Asian Americans;Black race;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;cancer subtypes;Caring;Catchment Area;Cervical;Clinical;Clinical Research;Collaborations;Colorectal;Colorectal Cancer;Communication;Communities;community advisory board;community based participatory research;community collaboration;community engaged research;community engagement;Community Health Aides;Community Health Education;Community Networks;community organizations;Community Outreach;Community Practice;Community Services;Disparity;Ensure;Equity;equity, diversity, and inclusion;ethnic diversity;evidence base;Evidence based practice;Excess Mortality;experience;Faculty;follower of religion Jewish;Fostering;Foundations;Funding;Guidelines;Head and neck structure;Health;health equity;Health equity research;high risk;Hispanic;improved;Incidence;Interdisciplinary Study;Intervention;Latinx;Lead;Liver;Long Island;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Melanoma;Microbe;minority communities;Minority Groups;Mission;Modeling;NCI Center for Cancer Research;New York;New York City;outcome disparities;patient navigation;patient oriented;Patients;personalized approach;Policies;Population;population health;Population Heterogeneity;prevent;Prevention;Privatization;programs;Public Health;Race;Recording of previous events;recruit;Research;Research Personnel;Research Priority;risk prediction model;Schools;Science;Scientist;screening;Services;social health determinants;Stomach;Testing;Translations;trend;triple-negative invasive breast carcinoma;Trust;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: NEEL, BENJAMIN G. (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Basic Science;Biotechnology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;catalyst;Catchment Area;Clinical;Clinical Sciences;Clinical Trials;Data;data hub;Development;Disease Management;early phase clinical trial;Faculty;Fostering;Funding;Funding Agency;Future;Goals;Grant;innovation;Institution;Intellectual Property;Interdisciplinary Study;interest;Intervention Studies;Investigation;investigator-initiated trial;Investments;Leadership;Legal patent;Malignant Neoplasms;Measures;member;metabolomics;Monitor;novel;Office of Administrative Management;Paper;Peer Review Grants;Pilot Projects;Population;Population Sciences;preference;Process;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;Science;Strategic Planning;success;System;Translational Research;United States National Institutes of Health;Vision

PROJECT_TITLE: Developmental Funds


PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: MEHNERT, JANICE M. (contact)

PROJECT_TERMS: Address;Adherence;Advisory Committees;Age;anti-cancer research;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Clinical;Clinical Cancer Center;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Communication;Consent Forms;COVID-19 pandemic;Data;data management;Dedications;Development;Disease Management;Employee;Ensure;Equity;ethnic diversity;Faculty;Funding;Goals;Health;Hospitals;Human Resources;Human Subject Research;improved;Individual;Informatics;Infrastructure;Institution;Investigational New Drug Application;investigator-initiated trial;Location;Long Island;Malignant Neoplasms;medical schools;medically underserved;medically underserved population;Monitor;Multicenter Trials;NCI Center for Cancer Research;New York;Office Management;Online Systems;operation;patient population;Patients;Physician Executives;Policies;Procedures;Protocols documentation;Public Hospitals;quality assurance;Quality Control;racial diversity;Regulation;Regulatory Affairs;Reporting;repository;Research;Research Activity;Research Infrastructure;Safety;Services;Standardization;Technology;Time;timeline;Training;Training and Education;Underrepresented Populations;Universities;Update;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: CHAN, NANCY  (contact)

PROJECT_TERMS: Address;Amendment;authority;Biomedical Research;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Catchment Area;Child;Childhood;Clinical Research;Clinical Trials;Clinical Trials Unit;Committee Membership;design;Discipline;Discipline of Nursing;Disease Management;Ensure;Equity;Ethics;Exhibits;Funding;Goals;Grant;Guidelines;Health;Industry;Institutional Review Boards;investigator-initiated trial;Leadership;Malignant Neoplasms;Measures;Medical;medical schools;Minority;Monitor;multidisciplinary;New York;Older Population;Operative Surgical Procedures;participant safety;Patient risk;pediatric patients;Peer Review;Pharmacy facility;Policies;Process;protocol development;Protocols documentation;Quality Control;Radiation;Radiation therapy;rare cancer;Research;Research Personnel;research study;Review Committee;Role;Safety;Science;Scientific Evaluation;sound;success;System;Translating;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: HEGUY, ADRIANA  (contact)

PROJECT_TERMS: Administrator;anti-cancer research;Applications Grants;assay development;Basic Science;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Clinical Research;Collaborations;cost effective;Custom;dashboard;Data Analyses;data management;Data Provenance;data sharing;Doctor of Philosophy;Emerging Technologies;Ensure;Equity;expectation;Experimental Designs;Experimental Pathology;Faculty;Funding;Genetic Engineering;Genome;Goals;Grant;Health Services Accessibility;Immunologic Monitoring;Incentives;Infrastructure;innovation;innovative technologies;Institution;instrumentation;Interdisciplinary Study;Investments;Laboratories;Leadership;Manuscripts;medical schools;meetings;member;metabolomics;Methods;Microscopy;Mission;NCI Center for Cancer Research;Needs Assessment;new technology;organizational structure;Population Research;preclinical imaging;Preparation;programs;Proteomics;Publications;Quality Control;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Services;Surveys;Technical Expertise;Technology;Technology Assessment;Training;Translational Research

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cost Effectiveness Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: TSIRIGOS, ARISTOTELIS  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Applications Grants;Bioinformatics;Biological Process;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer Diagnostics;cancer genetics;cancer genomics;Cells;Clinical Data;cluster computing;Collaborations;community center;computational pipelines;computational platform;Computer Analysis;cost;cost effective;Cost Effectiveness Analysis;cost efficient;Data;Data Analyses;data management;data quality;Data Scientist;Data Set;diverse data;Doctor of Philosophy;Education;Educational workshop;Ensure;Epigenetic Process;epigenomics;experience;Experimental Designs;Faculty;Funding;Future;Generations;genomic data;Genomics;Goals;Grant;High Performance Computing;Image;insight;Internships;Journals;Laboratories;Machine Learning;machine learning method;Manuscripts;Medicine;member;Methods;Mission;Modernization;multimodality;multiple omics;NCI Center for Cancer Research;novel;operation;Pathology;Peer Review;posters;Process;professor;programs;Publications;Recovery;Reproducibility;Research;Research Personnel;Resource Sharing;satisfaction;Services;Standardization;Surveys;Techniques;Technology;tool;Training;transcriptomics;Visualization;Wages;web interface;web portal

PROJECT_TITLE: Applied Bioinformatics Laboratory


PI_NAMEs: GOLDBERG, JUDITH D. (contact)

PROJECT_TERMS: Address;analytical method;Animal Experiments;anti-cancer research;Area;Bioinformatics;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Cancer Therapy Evaluation Program;cancer type;Clinical;Clinical Cancer Center;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Consultations;Data;Data Analyses;data management;data mining;Database Management Systems;Databases;Dedications;design;Development;Disease Management;Doctor of Philosophy;Education;Emerging Technologies;Ensure;epidemiology study;experience;Extramural Activities;Faculty;Funding;Genetic;genetic association;genetic linkage;Genome;Genomics;Grant;high throughput technology;In Vitro;in vivo;Industry;Informatics;innovation;Institution;Journals;Knowledge;Laboratories;Laboratory Study;Malignant Neoplasms;Manuscripts;medical schools;member;Mentors;Methodology;Methods;Monitor;NCI Center for Cancer Research;Observational Study;Peer Review;Pilot Projects;Play;population based;population health;Population Research;Population Study;pre-clinical;Prevention Research;Procedures;Process;professor;programs;Proteomics;protocol development;Publications;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Role;Safety;Scientist;senior faculty;Statistical Methods;Supplementation;Surveys;Technology;Training;Translational Research;translational study;Translations;Wages

PROJECT_TITLE: Biostatistics


PI_NAMEs: MOREIRA, ANDRE LUIS (contact)

PROJECT_TERMS: Accreditation;Agreement;American;Applications Grants;biobank;Biological Specimen Banks;Blood specimen;Cancer Center;Cancer Center Support Grant;Cancer Patient;Chest;Clinical Research;Clinical Trials;Collaborations;Collection;college;Community Health;Consent;digital pathology;Drug or chemical Tissue Distribution;Enrollment;Ensure;Ethics;experience;Faculty;Floor;Fostering;Funding;Future;Health;Histopathology;Human;Human Specimen Resources;human tissue;Industry;innovation;Institution;Institutional Review Boards;Laboratories;laboratory experience;Laws;Licensing;Link;Long Island;Malignant Neoplasms;Medical;medical schools;member;Mission;NCI Center for Cancer Research;New York;Nucleic Acids;participant enrollment;Pathologist;Pathology;Peer Review;Peer Review Grants;Policies;Process;professor;programs;prospective;Protocols documentation;Publications;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;Role;Science;Services;Specimen;Staff Development;Surveys;Technology;Tissue Banks;Tissue Sample;Tissues;Translational Research

PROJECT_TITLE: Center for Biospecimen Research & Development


PROJECT_TERMS: analysis pipeline;anti-cancer research;Applications Grants;Automation;Basic Science;Bioinformatics;bisulfite sequencing;Cancer Center;Cancer Center Support Grant;cancer genetics;career;Cells;Chromatin;Client satisfaction;Clinical;collaborative environment;community center;Core Facility;cost;cost effective;cost efficient;Data;Data Analyses;data sharing;Data Storage and Retrieval;distributed data;Doctor of Philosophy;Education;Ensure;epigenomics;exome sequencing;experience;Faculty;flexibility;Fostering;Funding;Future;Generations;Genome;genome sequencing;genomic data;Genomics;Grant;Health;High Performance Computing;Hour;Human;Human Resources;Institution;instrument;instrumentation;interest;International;Laboratories;Learning;Libraries;meetings;member;Mission;Modernization;Molecular Conformation;multiple omics;New York;operation;Pathology;Peer Review Grants;posters;Preparation;professor;programs;Publications;Recovery;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Running;Sampling;Science;Scientist;Secure;Series;Services;single cell sequencing;Specimen;Students;Surveys;symposium;Technology;Training;transcriptome sequencing;transcriptomics;Translational Research;Universities;Update;whole genome

PROJECT_TITLE: Genome Technology Center


PI_NAMEs: LOOMIS, CYNTHIA A (contact)

PROJECT_TERMS: animal tissue;Biological Assay;Biological Markers;Cancer Center;Cancer Center Support Grant;Certification;Clinic;Clinical Investigator;Collaborations;Computer software;cost effective;Detection;Developmental Biology;Disease;Doctor of Philosophy;Ensure;experience;Experimental Pathology;Faculty;Funding;Future;Genome;histotechnology;Human;human tissue;Image Analysis;Immunologic Monitoring;In Situ;Institution;Institutional Review Boards;interest;International;investigator training;Laboratories;Laboratory Research;Malignant Neoplasms;member;metabolomics;Microscopy;Mission;Modeling;Molecular;Molecular Analysis;Morphology;multidisciplinary;NCI Center for Cancer Research;Network-based;neural network;New York;novel strategies;Peer Review Grants;Positioning Attribute;pre-clinical;Procedures;programs;Reproducibility;Research;research and development;Research Personnel;Resource Sharing;Resources;Sampling;Scientist;Services;Standardization;Surveys;Technology;Testing;tissue preparation;Tissues;Training;transcriptomics;Translational Research;tumor;Work

PROJECT_TITLE: Experimental Pathology Laboratory


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: BORGHI, SARA  (contact)

PROJECT_TERMS: Academia;Advisory Committees;anti-cancer research;anti-tumor immune response;Antibodies;Area;Basic Science;Bioinformatics;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cell Separation;Cells;Clinic;Clinical;Clinical Research;clinical translation;Collaborations;collaborative environment;community center;cost;Custom;Cytometry;Data Analyses;design;Development;Doctor of Philosophy;educational atmosphere;Emerging Technologies;experience;Experimental Designs;Experimental Pathology;Faculty;flexibility;Flow Cytometry;Funding;Future;Genome;Goals;Health;Hour;Human;Immune;Immunologic Monitoring;Immunologist;Immunology;Immunophenotyping;Immunotherapy;immunotherapy trials;Individual;Industry;instrumentation;Laboratories;Leadership;medical schools;meetings;member;metabolomics;Methodology;mid-career faculty;Mission;Modernization;multimodality;NCI Center for Cancer Research;Needs Assessment;operation;Pathology;patient response;Peer Review;Peer Review Grants;Phenotype;Positioning Attribute;professor;programs;Protocols documentation;Publications;Recovery;Research;research and development;Research Personnel;Resource Sharing;Scientist;Services;single cell analysis;single cell technology;Specimen;Students;Surveys;Technology;Toxic effect;Training;Translational Research;tumor immunology;Universities;Vaccine Research

PROJECT_TITLE: Immune Monitoring Laboratory


PI_NAMEs: JONES, DREW R (contact)

PROJECT_TERMS: Accounting;Analytical Chemistry;anti-cancer research;Basic Science;Biochemistry;Bioinformatics;Biological Models;Cancer Center;Cancer Center Support Grant;Client;Clinical;collaborative environment;complex data;computerized data processing;Consultations;Custom;Data;data acquisition;Data Analyses;Data Set;Data Storage and Retrieval;Development;Doctor of Philosophy;Education;Ensure;Evaluation;experience;Experimental Designs;experimental study;Faculty;Fostering;Future;Generations;Goals;graduate student;Harvest;Individual;Informatics;informatics tool;instrument;instrumentation;interest;Laboratories;Laboratory Research;Learning;lipidomics;mass spectrometric imaging;Mass Spectrum Analysis;member;Mentors;metabolic phenotype;Metabolism;metabolomics;method development;Methods;Mission;Molecular;multiple omics;NCI Center for Cancer Research;new technology;novel;Paper;Peer Review;Pharmacology;Play;Postdoctoral Fellow;Productivity;professor;programs;Publications;Publishing;Quality Control;Radiation Oncology;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Sampling;satisfaction;Scientist;Services;small molecule;Students;success;Surveys;Technology;technology platform;theories;Training;Translational Research;tumor metabolism;Update;Work

PROJECT_TITLE: Metabolomics Laboratory


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: LIANG, FENGXIA  (contact)

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Applications Grants;Basic Cancer Research;Biology;Book Chapters;Cancer Center;Cancer Center Support Grant;Cellular biology;collaborative environment;Communities;Consultations;cost;cost effective;cost efficient;Cryoelectron Microscopy;Data;Data Analyses;data management;Data Provenance;data sharing networks;design;Doctor of Philosophy;Electron Microscopy;Electrons;Ensure;Equipment;experience;Experimental Designs;Faculty;flexibility;Fostering;Funding;Future;Generations;Grant;high resolution imaging;Hour;Image;Image Analysis;imaging modality;Imaging technology;improved;innovation;Institution;instrument;instrumentation;Interdisciplinary Study;interest;International;Laboratories;Learning;Light;light microscopy;member;Microscope;microscopic imaging;Microscopy;Mission;Modernization;NCI Center for Cancer Research;operation;Optics;Peer Review;Peer Review Grants;posters;Preparation;professor;programs;Protocols documentation;Publications;Publishing;Quality Control;Recovery;recruit;Research;Resolution;Resource Sharing;Resources;Rice;Sampling;Science;Series;Services;Societies;Structure;Students;superresolution microscopy;Surveys;Technology;Three-Dimensional Imaging;Training;Training and Education;translational cancer research;two-dimensional;Update

PROJECT_TITLE: Microscopy Laboratory


PI_NAMEs: WADGHIRI, YOUSSEF ZAIM (contact)

PROJECT_TERMS: Anatomy;animal imaging;anti-cancer research;Bioluminescence;bioluminescence imaging;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Model;Cells;Clinical;collaborative environment;Communities;Computer software;cost effective;Data Analyses;data management;Data Provenance;data sharing;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Ensure;Environment;Equipment;experience;Experimental Designs;fluorescence imaging;Fostering;Frequencies;Funding;Grant;Growth;Image;image guided intervention;imaging approach;imaging capabilities;Imaging Device;imaging modality;Imaging technology;instrument;instrumentation;International;Interventional Imaging;Journals;Laboratories;Learning;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;medical schools;meetings;member;Metabolic;Methodology;Mission;Modality;Modernization;Molecular;molecular imaging;Molecular Probes;Mus;Nature;NCI Center for Cancer Research;Needs Assessment;new technology;Organ;Peer Review;Performance;Photons;Positron-Emission Tomography;pre-clinical;preclinical imaging;programs;Publications;Quality Control;Research;Research Personnel;Resource Sharing;Resources;response;Rodent;satisfaction;Scientist;screening;Secure;Services;Surveys;tomography;Training;Training and Education;ultrasound;Update

PROJECT_TITLE: Preclinical Imagining Labs


PI_NAMEs: UEBERHEIDE, BEATRIX MAGDALENA (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Biochemistry;Biological;Cancer Center;Cancer Center Support Grant;Clinical;Collaborations;collaborative environment;Computer software;Consult;Consultations;cost;cost effective;Data;Data Analyses;data analysis pipeline;data quality;Data Reporting;data sharing networks;Data Storage and Retrieval;Development;Doctor of Philosophy;Education;Educational process of instructing;Ensure;experience;Experimental Designs;Faculty;flexibility;Fostering;Funding;Future;Generations;graduate student;Grant;High Pressure Liquid Chromatography;Higher Order Chromatin Structure;Hour;improved;Individual;innovation;Institution;instrumentation;interest;International;Label;Laboratories;Learning;Licensing;mass spectrometer;Mass Spectrum Analysis;member;Methods;mid-career faculty;Mission;Modeling;Molecular;NCI Center for Cancer Research;Neurology;novel;operation;Outcome;Pharmacology;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;Principal Investigator;programs;Protein Analysis;protein complex;Proteomics;Publications;Quality Control;Recommendation;Recovery;Reporting;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Sampling;Science;Scientist;Secure;Services;Statistical Data Interpretation;Students;success;Suggestion;Supervision;Surveys;symposium;Technical Expertise;Techniques;Technology;Training;Update

PROJECT_TITLE: Proteomics Laboratory


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: KIM, SANG YONG  (contact)

PROJECT_TERMS: Animal Genetics;Animal Housing;Basic Cancer Research;Cancer Center;Cancer Center Support Grant;Cancer Model;Chromosomes;Complex;cost;cost effective;data sharing networks;Dedications;Derivation procedure;Development;Doctor of Philosophy;Drug Screening;educational atmosphere;Elements;Emerging Technologies;Engineering;Ensure;Environment;experience;Faculty;Funding;Future;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Engineering;Genetic Models;Genetically Engineered Mouse;Genome engineering;Genotype;germ free condition;Germ Lines;Goals;Grant;human model;innovation;Knock-in Mouse;Knock-out;Laboratories;Malignant Neoplasms;member;Methodology;mid-career faculty;Mission;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;Mutant Strains Mice;Mutation;NCI Center for Cancer Research;new technology;novel strategies;Pathology;Peer Review Grants;Pre-Clinical Model;pre-clinical research;Procedures;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;Rodent;Science;Scientist;Services;square foot;Students;Surveys;Technical Expertise;Technology;Therapeutic;Time;timeline;Training;Transgenic Organisms;translational cancer research;Validation;Vendor;Work

PROJECT_TITLE: Rodent Genetic Engineering Lab


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Immune Dysregulation is well described to be a fundamental mechanism of a diverse set of pathologic states including autoimmune/inflammatory, infectious, genetic, hematologic, lymphoproliferative, gastroenterologic and neurologic diseases. The major goal of this new Physician Scientist Training Program in Immune Dysregulation is to successfully train the next generation of Physician-Scientists working at the interface of normal and pathologic immune function with end-organ damage to elucidate the root causes of immune dysregulation syndromes and to develop novel approaches towards their diagnosis, monitoring and treatment.

PI_NAMEs: BEHRENS, EDWARD M;KAMBAYASHI, TAKU  (contact);PEAR, WARREN S

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (S2)]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Cancer prevention and control research remains a high priority for the NCI. The proposed training program will train cancer control and prevention researchers to become independent and productive scientists to advance the national priorities in improving access and quality of cancer prevention, detection and treatment and to advance the national goal of further reducing the burden of cancer.

PI_NAMEs: DOUBENI, CHYKE ABADAMA;SHIELDS, PETER G. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Control;cancer prevention;Training Programs

PROJECT_TITLE: Training Program for Cancer Prevention and Control

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Cardiovascular disease remains the major cause of death in the US and around the world. Improvements in prevention and treatment for cardiovascular disease will come from research in multiple areas, encompassing basic laboratory research, human population studies, and clinical investigation. The goal of this program is to train the next generation of cardiovascular investigators across this range, so they gain the skills, concepts, and experiences required to initiate and sustain successful long-term independent careers dedicated to decreasing the burden of cardiovascular disease in our society.

PI_NAMEs: RODRIGUEZ, CARLOS JOSE;SIBINGA, NICHOLAS E (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Cardiovascular Diseases

PROJECT_TITLE: Mechanisms of cardiovascular disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Chemistry-Biology Interface Training (CBIT) Program is a unique graduate training program at the University of Wisconsin–Madison centered on an appreciation of the blending of chemical and biological methods to solve biomedical problems. The mission of the CBIT Program is to educate graduate students to recognize and address these problems using innovative and rigorous approaches, to provide professional development skills and career mentorship that will allow them to succeed and lead in the biomedical workforce, and to cultivate an inclusive, safe, and engaged community of cross-disciplinary scholars that is fostered by strong communication and teamwork. This focus on both interfacial research training and community will a ract and retain students, and is ideal preparation for designing, discovering, and developing the next generation of therapies that will directly impact human health.

PI_NAMEs: BLACKWELL, HELEN E. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biology;Chemistry;Training Programs

PROJECT_TITLE: Chemistry-Biology Interface Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Central to our new training program is the commitment to educate a diverse population of students to think critically, conduct science in a rigorous, reproducible and ethical manner, work effectively in interdisciplinary teams, and communicate with a variety of audiences. In addition to coursework and a deep immersion in a research laboratory, our trainees will participate in a choice of enrichment tracks focused on Communication, Community Engagement and Advocacy, Education, and Innovation and Entrepreneurship. Our students will be prepared to make important contributions within the changing landscape of contemporary biomedical science.

PI_NAMEs: BRADSHAW, AMY D;O'BRYAN, JOHN P (contact)

PROJECT_TITLE: Cellular, Biochemical and Molecular Sciences Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE The International Skin Imaging Collaboration (ISIC) Archive is the leading publicly available skin imaging repository and has made major contributions to the dermatology and computer science communities' efforts toward the development of visual aids and artificial intelligence tools for skin cancer diagnosis. In this project, we will make the ISIC Archive fully compliant with the FAIR principles (findability, accessibility, interoperability, and reusability), expand the Archive to include clinical images and total body photography, and advance the development and application of skin imaging standards to improve quality and interoperability. Through these major enhancements, we will make the ISIC Archive a considerably more useful, impactful, and sustainable resource for research to improve the early and accurate diagnosis of skin cancer.

PI_NAMEs: HALPERN, ALLAN C (contact);KOSE, KIVANC

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: accurate diagnosis;Address;Adoption;Advanced Development;advanced disease;Agreement;Anatomy;Archives;Artificial Intelligence;Back;Basal cell carcinoma;Biopsy;cancer diagnosis;Cessation of life;Clinical;clinical application;clinical imaging;Collaborations;Collection;Communities;Community Medicine;computer science;Computer software;Consensus;Data;data dictionary;data format;data repository;Data Set;Dermatologic;Dermatology;Development;Diagnosis;digital communication;diverse data;Early Diagnosis;Education and Outreach;Educational process of instructing;Educational workshop;FAIR principles;Goals;Image;image archival system;imaging modality;Improve Access;improved;Ingestion;International;interoperability;Label;Leadership;Lesion;Machine Learning;Malignant Epithelial Cell;Malignant Neoplasms;Medicine;Melanoma;Memorial Sloan-Kettering Cancer Center;Metadata;mobile computing;Morbidity - disease rate;mortality;Nomenclature;Paper;Participant;patient privacy;Patients;Peer Review;Photography;Privacy;Process;Publications;Publishing;Readability;Reporting;repository;Research Personnel;Research Support;Resources;Skin;Skin Cancer;Software Tools;Squamous cell carcinoma;Structure;sustainable resource;technical report;Technology;tool;user-friendly;vision development;Visual Aid

PROJECT_TITLE: ISIC-REPO; ISIC Skin Imaging Repository Enhancements for Promoting Interoperability and Utilization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative The research and education of trainees in our Chemical Biology Interface (CBI) Program transcends size scales, from the atomic to the cellular levels. We provide training and exposure in techniques to probe, design, manipulate, or build molecules and complex systems. Funds will be used to implement the proposed plan that has fantastic core Chemical Biology curriculum, Mentor Training for the faculty, and Multiple Paths to make our CBI Program inclusive to everyone.

PI_NAMEs: GRIMES, CATHERINE LEIMKUHLER (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Chemistry-Biology Interface Predoctoral Training Grant 2024-2029


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This program produces physician scientists who have both MD and PhD training, i.e., who receive both degrees at the completion of the program. MD-PhD graduates have deeper perceptions of medical significance in biology than do scientists without medical education, more comprehensive understanding of the limitations in medical practice, and greater ability to transfer basic scientific advances toward patient care advances. Thus, MD-PhD graduates are positioned to identify and pursue interdisciplinary approaches to important biomedical problems, and to help bridge the basic and clinical sciences.

PI_NAMEs: AJILORE, OLUSOLA A.;DARBAR, DAWOOD  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Cardiovascular diseases remain the leading cause of death in the United States and worldwide and are also a significant cause of premature death and disability. Multidisciplinary efforts that bring together investigators with complementary knowledge, tools and skills and integrate laboratory and patient-based research are essential for ongoing efforts to leverage information about mechanisms of disease into rationale therapeutic approaches for treatment of cardiovascular diseases. This Training Program offers an exceptional faculty in a strong multidisciplinary, diverse, and collaborative environment at UCSF, a top biomedical research institution, to train future leaders in cardiovascular research.

PI_NAMEs: BLACK, BRIAN L (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Cardiovascular Diseases;Molecular

PROJECT_TITLE: Molecular and Cellular Basis of Cardiovascular Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE The current proposal is a new resident research training program in the Department of Neurological Surgery at the OSU. There is critical need to enhance biomedical and clinical research training to develop and retain clinician-scientists, particularly in the field of neurosurgery. The broad objectives of this training program are to provide training to neurological surgery residents in the clinical, translational and basic sciences.

PI_NAMEs: HERSON, PACO S (contact);LONSER, RUSSELL

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Basic Science;Biomedical Research;career;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical training;Collaborations;Data;design;Development;didactic education;Discipline;Disease;Education Projects;education research;Educational Curriculum;Ensure;Financial Support;Funding;Human;interest;Investigation;Lesion;Medical center;Mentors;Mentorship;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;Neurosurgeon;neurosurgery;Neurosurgical Procedures;novel therapeutics;Ohio;Operating Rooms;Operative Surgical Procedures;Persons;Physiological;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Residencies;Science;Scientist;senior faculty;Series;Specific qualifier value;success;Technology;Tissues;tool;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Ohio State University Wexner Medical Center R25 Neurological Surgery Resident Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (03)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cannabidiol Research;Cannabinoid Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Pediatric;Substance Misuse;Therapeutic Cannabinoid Research;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Exposing the immature brain to cannabinoids can have detrimental long-lasting consequences by interfering with normal neurodevelopment, and emerging evidence from clinical and preclinical studies suggests an association between early-life cannabinoid exposure and cognitive abnormalities. In this proposal, we will investigate the neural mechanisms underlying the consequences of early-life cannabinoid exposure. The outcome of this proposal will reveal the developmental processes and sensitive periods of cannabinoid exposure, and significantly contribute to clinical efforts for risk assessment and timely interventions.

PI_NAMEs: CHE, ALICIA YUE (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Address;Adolescence;Adult;Affect;anxiety-related behavior;Behavior;Behavior assessment;Behavioral;behavioral outcome;Brain;Calcium;calcium indicator;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;cell type;Cells;Child;Cholecystokinin;Clinical;Clinical Data;Clinical Research;CNR1 gene;Cognitive;Cognitive deficits;cognitive task;cohort;Consumption;Data;Development;Developmental Process;early life exposure;emerging adult;Emotional;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Equilibrium;exogenous cannabinoid;Exposure to;Goals;Guidelines;Head;hippocampal pyramidal neuron;illicit drug use;Image;Imaging Techniques;in vivo;Interneurons;Intervention;Lactation;late life;Legal;Life;Link;Long-Term Effects;marijuana use;Measures;Medial;Mediating;Medical;Mood Disorders;Mothers;Mus;Natural Remedy;Neonatal;neural;neural correlate;neurodevelopment;neuromechanism;Neurons;novel;nursing mothers;Outcome;patch clamp;Pattern;Perception;Performance;Perinatal;pharmacologic;Population;postnatal;Postpartum Period;pre-clinical;preclinical study;Prefrontal Cortex;Pregnancy;Pregnant Women;prenatal;pup;rabies viral tracing;Receptor Activation;receptor expression;Risk;Risk Assessment;Role;sensor;social;Synapses;Testing;Tetrahydrocannabinol;THC exposure;translational impact;two-photon

PROJECT_TITLE: Effects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across Development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The objective of this renewal application is to prepare 4 academically-oriented MD an PhD trained investigators for research-intensive careers in cardiovascular disease (CVD) epidemiology and prevention. We will accomplish this over a 2-year training period by continuing to use a competency-based training framework with regular self-evaluation of mastery. The learning opportunities are provided by a combination of mentored research activities, coursework and seminars/workshops led by accomplished senior mentors.

PI_NAMEs: CARNETHON, MERCEDES RENEE (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TITLE: Research Training in CVD Epidemiology and Prevention


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: STRATFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project Narrative The proposed research is relevant to public health because it focuses on understanding the neurological mechanisms of treatment resistance behind a major impairment in Parkinson’s disease, swallowing difficulties, in an epidemiologically relevant model. Understanding the specific neurophysiological underpinnings of oropharyngeal dysfunction in Parkinson’s disease will identify potential targets for treatments and biomarkers. This research will serve the goals of NIEHS by providing a mechanistic understanding of the impact of multi locus neurodegeneration on a specific clinically significant function, feeding, in a toxicological exposure model of Parkinson’s disease.

PI_NAMEs: GOULD, FRANCOIS  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Affect;Animal Model;Aspiration Pneumonia;behavior test;Behavior Therapy;Behavioral;Behavioral Model;Biological Markers;Biomechanics;Bolus Infusion;Brain;Brain Pathology;Brain region;Breathing;Cause of Death;Chronic;Clinical;clinically significant;Complex;Corpus striatum structure;Deglutition;Deglutition Disorders;Disease;Dopamine;drinking;early onset;Eating;effective therapy;Ensure;Epidemiology;Exposure to;feeding;Food;Functional disorder;Generations;Goals;Impairment;improved;Individual;Injections;innovation;Intervention;Investigation;Jaw;Knowledge;Lesion;Levodopa;Liquid substance;Mastication;Modeling;Morbidity - disease rate;mortality;motor impairment;National Institute of Environmental Health Sciences;Nature;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;Neurologic;neuromuscular;neuropathology;neurophysiology;Oral;Oropharyngeal;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;parkinsonian model;Pathologic;Patients;Pesticides;pharmacologic;Pharmacology;Pharyngeal structure;Phase;Phenotype;Poison;Population;Positioning Attribute;preservation;Process;Property;Public Health;Quality of life;Rattus;Research;Resistance;Respiration;restoration;Role;Rotenone;Severities;Solid;Substantia nigra structure;symptom treatment;Symptoms;targeted treatment;Testing;Therapeutic Intervention;therapy resistant;Toxicology;Work

PROJECT_TITLE: Impact of nigral and extranigral neurodegeneration on aerodigestive discoordination in a pesticide model of Parkinson's disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative This training program in basic, clinical, and translational research will train basic and physician scientists in mechanisms and management of pain, perioperative stress biology and outcomes, health service and translational research, and personalized medicine and pharmacogenomics. The program will prepare future researchers for the unique challenges associated with the optimization of perioperative care.

PI_NAMEs: DELPIRE, ERIC J (contact)

PROJECT_TERMS: Perioperative;Science;Training

PROJECT_TITLE: TIPS: Training in Perioperative Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (PD)]


PHR: PROJECT NARRATIVE – OVERALL The UCSF Prostate Cancer SPORE seeks to reduce the morbidity and mortality associated with prostate cancer by leveraging a deep understanding of the disease to translate biological findings into clinical impact. In this SPORE application, three translational projects focus on developing novel biomarkers and highly effective therapies for patients with aggressive prostate cancer. These projects are highly collaborative with respect to the multidisciplinary nature and expertise of the Co-Leaders.

PI_NAMEs: FENG, FELIX YI-CHUNG;SMALL, ERIC J (contact)

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: Acceleration;Address;advanced disease;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;bench to bedside;bench-to-bedside translation;Bioinformatics;Biological;Biological Markers;Biology;Biometry;California;Cancer Center Support Grant;cancer clinical trial;Cancer Etiology;Cancer Patient;career;Castrate sensitive prostate cancer;Cells;Cessation of life;Classification;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Combination immunotherapy;Comprehensive Cancer Center;design;Development;Direct Costs;Disease;Disease Progression;effective therapy;Family;Fostering;Funding;Future;Generations;Genetic;Genomics;Goals;Grant;Growth and Development function;Health;Hypermethylation;improved;Infrastructure;inhibitor;innovation;Institution;interdisciplinary collaboration;Laboratory Scientists;Life Support Care;Malignant neoplasm of prostate;men;Mentors;Mentorship;Metastatic Prostate Cancer;Mission;Molecular;molecular diagnostics;molecular marker;molecular subtypes;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Program;National Clinical Trials Network;Nature;NCI-Designated Cancer Center;new therapeutic target;next generation;novel;novel marker;novel therapeutics;Oncogenic;Outcome;Pathology;Patients;Peer Review;personalized medicine;Pharmacologic Substance;Pre-Clinical Model;Process;Productivity;programs;Prostate;Publishing;radioligand;Receptor Signaling;Records;Refractory Disease;Research;Research Personnel;Research Project Grants;Resources;response;Role;San Francisco;Scientist;Societies;Specialized Program of Research Excellence;targeted treatment;Therapeutic;therapy development;therapy resistant;Tissues;Translating;Translational Research;translational scientist;Translations;United States;Universities;virtual

PROJECT_TITLE: UCSF Specialized Programs of Research Excellence (SPOREs) in Prostate Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: FENG, FELIX YI-CHUNG (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Basic Science;Biotechnology;cancer immunotherapy;Cancer Patient;career;Catchment Area;Clinical Research;Clinical Trials Unit;Collaborations;Communication;Communities;Comprehensive Cancer Center;cost effectiveness;data management;data sharing;Development;early phase clinical trial;Elements;Ensure;Evaluation;Family;federal policy;Funding;Genomics;Goals;Grant;Immunologic Monitoring;Infrastructure;Institution;Leadership;Malignant neoplasm of prostate;meetings;Mentorship;molecular oncology;Monitor;Office Management;Office of Administrative Management;oncology program;Patient advocacy;patient population;Patient Recruitments;Patients;Performance;Procedures;Process;Productivity;programs;prostate cancer metastasis;Publications;Recording of previous events;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Specialized Program of Research Excellence;Strategic vision;success;Tissue Banks;Translational Research;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT 1 (FONG): COMBINATION IMMUNOTHERAPY WITH RADIOLIGAND THERAPY FOR METASTATIC PROSTATE CANCER The goal of this project is to dissect the immunogenic capacity of 177Lu-PMSA-617 to prime a T cell response in combination with immune checkpoint inhibition for patients with advanced prostate cancer. Defining and functionally validating the immunogenic impact of systemic radioligand therapy (RLT) with 177Lu-PSMA-617 would significantly accelerate the development and optimization of combinatorial approaches to induce more potent anti-tumor immunity and more durable clinical efficacy.

PI_NAMEs: FONG, LAWRENCE  (contact)

PROJECT_TERMS: Acceleration;Address;advanced prostate cancer;Alpha Particles;androgen independent prostate cancer;anti-PD-1;Beta Particle;Biological Markers;Biopsy Specimen;Blood specimen;Cancer Patient;Cells;checkpoint inhibition;Circulation;Clinical;clinical effect;clinical efficacy;Clinical Research;Clinical Trials;Clone Cells;Combination immunotherapy;combinatorial;Combined Modality Therapy;Development;Dose;exhaustion;External Beam Radiation Therapy;FOLH1 gene;Future;Goals;Granzyme;Human;Immune;Immune checkpoint inhibitor;Immune response;immunogenic;immunogenic cell death;immunogenicity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Malignant neoplasm of prostate;Mediating;men;Metastatic Prostate Cancer;microscopic imaging;Molecular Target;mouse model;multiple omics;Multiplexed Ion Beam Imaging;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;Outcome;particle;patient biomarkers;Patient Selection;Patients;pembrolizumab;Phase;Phase Ib Trial;Phase II Clinical Trials;Phase III Clinical Trials;Population;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;Progression-Free Survivals;prospective;Proteomics;pyrrolidin-3-yl-methanesulfonic acid;Radiation;Radiation therapy;Radioimmunotherapy;radioligand;radiotracer;randomized trial;Reporting;Research Personnel;response;Role;Schedule;single cell analysis;single-cell RNA sequencing;Spatial Distribution;Specialized Program of Research Excellence;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;targeted treatment;Techniques;Testing;Time;translational study;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Visualization

PROJECT_TITLE: Project 1-Combination Immunotherapy with  Radioligned Therapy for Metastatic Prostate Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT 2 (SMALL): INVESTIGATING CLINICAL AND BIOLOGICAL IMPLICATIONS OF A NOVEL HYPERMETHYLATED SUBTYPE OF METASTATIC CASTRATION RESISTANT PROSTATE CANCER (MCRPC) The lethal manifestation of prostate cancer, metastatic Castration Resistant Prostate Cancer (mCRPC), is the second most common cause of cancer deaths in men in the US, accounting for approximately 35,000 deaths in 2021. We have identified a novel hypermethylated subset of mCRPC accounting for 22% of all mCRPC cases in our series, making it one of the most common subtypes of mCRPC. The proposed studies will define the clinical and biologic implications of this observation and identify therapeutic approaches for this subtype of mCRPC.

PI_NAMEs: SMALL, ERIC J (contact)

PROJECT_TERMS: Accounting;Address;Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgens;ATAC-seq;Biological;Biological Markers;Biopsy;bisulfite sequencing;BRAF gene;Cancer Etiology;Cancer Patient;cancer subtypes;cancer type;Castrate sensitive prostate cancer;Cell Line;Cessation of life;Chromatin;Clinical;clinically relevant;cohort;Colon Carcinoma;CRISPR interference;Decitabine;demethylation;Disease;disease phenotype;Disease Progression;DNA Methylation;DNMT3B gene;Dreams;Drug Screening;efficacy evaluation;Engineering;Enrollment;Epigenetic Process;Equilibrium;Exhibits;Gene Activation;Gene Silencing;Genes;Genetic Transcription;genome sequencing;genome wide methylation;genome-wide;Genomics;Glioblastoma;Histone Deacetylase Inhibitor;Hypermethylation;In Vitro;in vivo Model;inhibitor;Intervention;Invaded;Knowledge;Malignant neoplasm of prostate;men;Methylation;methylation biomarker;methylome;Modeling;Modification;Molecular;molecular subtypes;Mutation;Neoplasm Metastasis;new therapeutic target;Nonmetastatic;novel;Nucleic Acid Regulatory Sequences;Oncogenic;Pathway interactions;patient subsets;Patients;Phenotype;potential biomarker;predictive marker;Prognostic Marker;Proliferating;prostate cancer cell line;prostate cancer metastasis;prostate cancer progression;randomized, clinical trials;Recurrence;response;response biomarker;RNA Conformation;Sampling;Series;Signal Transduction;Specialized Program of Research Excellence;success;Testing;Therapeutic;therapeutic target;Therapeutic Trials;Tissues;transcriptome sequencing;transcriptomics;translational potential;Translations;tumor;tumor DNA;whole genome

PROJECT_TITLE: Project 2 - Investigating Clinical and Biological Implications of a Novel Hypermethylated Subtype of Metastatic Castration Resistant Prostate Cancer (mCRPC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE – PROJECT 3 (RUGGERO): DECIPHERING THE ROLE OF THE TRANSLATIONAL ONCOGENIC PROGRAM IN PROSTATE CANCER Up to 30% of patients on approved treatments for castrate-resistant prostate cancer develop primary refractory disease, and over time, all patients inevitably develop disease progression. Therefore, there is an urgent need for the development of novel alternative therapies for these patients.

PI_NAMEs: RUGGERO, DAVIDE  (contact)

PROJECT_TERMS: abiraterone;Acetates;Address;Alternative Therapies;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Biopsy;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer genome;Cancer Patient;Candidate Disease Gene;candidate validation;Castration;Cessation of life;chemotherapy;Classification;Clinical;Clinical Trials;Coupled;CRISPR interference;Data;Development;Disease Progression;Drug Kinetics;enzalutamide;Eukaryotic Initiation Factors;experience;Future;Gene Expression Profile;Genes;Genetic;Growth;Human;Immunofluorescence Immunologic;In Transferrin;In Vitro;in vivo;inhibitor;insight;interleukin-11 receptor;Knowledge;Laboratories;Lead;Length;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Messenger RNA;Metastatic Prostate Cancer;Mitogen-Activated Protein Kinases;Molecular;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Oncogenic;open label;participant enrollment;Pathway interactions;patient derived xenograft model;Patients;pharmacodynamic biomarker;pharmacologic;Phase;Phenotype;Phosphorylation;Positioning Attribute;potential biomarker;pre-clinical;Preclinical Testing;programs;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Proteome;receptor;Receptor Signaling;Refractory Disease;Regulation;Resistance;Resistance development;response biomarker;ribosome profiling;RNA Cap-Binding Proteins;RNA Splicing;Role;Safety;Serine;Signal Transduction;small molecule;Specialized Program of Research Excellence;Stains;targeted treatment;Therapeutic;therapy resistant;Time;Transferrin;Translating;translation factor;Translations;tumor;Tumor Burden;tumor growth;tumorigenesis;Up-Regulation;Validation;Variant

PROJECT_TITLE: Project 3 - Deciphering the Role of the Translational Oncogenic Program in Prostate Cance


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE – CORE 1 - BIOSTATISTICS AND BIOINFORMATICS CORE (BBC) The Biostatistics and Bioinformatics Core is critical to the success of the UCSF Prostate SPORE. It has participated in a meaningful way in the planning and design of the proposed projects, with the ultimate goal to decrease the morbidity and mortality of prostate cancer through innovative research that is supported by rigorous bioinformatics and biostatistical support.

PI_NAMEs: KIM, MI-OK  (contact)

PROJECT_TERMS: Agreement;anti-cancer research;Area;ATAC-seq;Bioinformatics;Biometry;Biostatistics Core;career;ChIP-seq;Clinical;Clinical Research;clinical trial analysis;Clinical Trials;Collaborations;Communities;Complex;Computer Analysis;computing resources;Conduct Clinical Trials;Data;data access;Data Analyses;Data Collection;data de-identification;data management;data sharing;Data Sources;Databases;design;Development;Ensure;experience;Experimental Designs;experimental study;Faculty;Fertilization;Formulation;genome sequencing;genomic data;Genomics;Germ-Line Mutation;Goals;Human Resources;Individual;Information Dissemination;Infrastructure;innovation;Laboratories;Laboratory Study;Leadership;Malignant neoplasm of prostate;Metadata;Methylation;Monitoring Clinical Trials;Morbidity - disease rate;mortality;Nature;Participant;Policies;pre-clinical;Process;programs;Prostate;Qualifying;Quality Control;Reporting;repository;Reproducibility;Reproduction spores;Research;Research Personnel;Research Project Grants;Resources;Science;Scientist;Side;Somatic Mutation;Specialized Program of Research Excellence;success;transcriptomics;Translational Research;translational study;United States National Institutes of Health

PROJECT_TITLE: Core 1 - Biostatistics and Bioinformatics Core  (BBC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE - CORE 2: PROSTATE TISSUE CORE (PTC) The collection, management and distribution of high quality and well annotated biospecimens linked to highly detailed patient clinical and outcome information for use by the cancer research community, which is the mission of the Prostate Tissue Core (PTC), allows for the translational studies to be performed that are necessary for validating new biomarkers and for testing new concepts related to therapeutic targeting. Thus, such a resource is invaluable to the more rapid translation of basic science discoveries into the clinical setting, ultimately leading to improved care of people suffering from cancer.

PI_NAMEs: SIMKO, JEFF P (contact)

PROJECT_TERMS: Agreement;androgen independent prostate cancer;anti-cancer research;Basic Science;Bioinformatics;Biological Markers;Biological Specimen database;Biometry;Biopsy;Blood;Body Fluids;California;Cancer Center;Caring;Catalogs;Cell Line;Cell model;Clinical;clinical database;Clinical Research;Clinics and Hospitals;Collaborations;Collection;Communities;Confidentiality of Patient Information;Consent;Data;Data Set;Databases;Dedications;design;Development;digital;DNA;Drug or chemical Tissue Distribution;Ensure;follow-up;Freezing;Fresh Tissue;Funding;Goals;Health protection;Histology;Histopathology;human tissue;improved;Individual;Institution;Laboratories;laser capture microdissection;Libraries;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncologist;Medical Research;Medicine;Mission;model development;Monitor;National Clinical Trials Network;organizational structure;Outcome;Paper;Paraffin;Pathologist;Pathology;Patients;Peer Review;Persons;Pre-Clinical Model;Preparation;Process;programs;Prostate;Quality Control;recruit;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;Review Committee;RNA;Running;San Francisco;Scanning;Service delivery model;Services;Slide;Source;Specialized Program of Research Excellence;Specimen;Stains;Testing;therapeutic target;Tissue Banks;Tissue Embedding;Tissue Microarray;Tissues;translational study;Translations;Universities;University resources;Urine;Urologist;Urology;volunteer;Work

PROJECT_TITLE: Core 2 - Prostate Tissue Core (PTC)


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: ASHWORTH, ALAN  (contact)

PROJECT_TERMS: anti-cancer research;Award;career;Clinical;Collaborations;Comprehensive Cancer Center;data repository;Development;Discipline;Educational workshop;Ensure;Environment;Equity;Ethnic Population;Evaluation;Family;Funding;Funding Opportunities;Genomics;Goals;Grant;Health Sciences;high risk;Human;Incubators;innovation;Institution;Life;Malignant neoplasm of prostate;Mission;novel;organizational structure;Outcome;Peer Review;Process;Productivity;Program Research Project Grants;programs;Progress Reports;Prostate;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Science;Special Exceptions Process;Specialized Program of Research Excellence;symposium;Tissues;translational potential;Translational Research;translational scientist;Universities

PROJECT_TITLE: Developmental Research Program (DRP)


PI_NAMEs: CARROLL, PETER R (contact)

PROJECT_TERMS: anti-cancer research;Award;Basic Science;career;career development;Clinical;Clinical Sciences;Communication;Comprehensive Cancer Center;Department chair;Development;disability;Disabled Persons;early-career faculty;Educational workshop;Eligibility Determination;Ensure;ethnic minority;Ethnic Population;experience;Faculty;Family;Financial Support;Funding;Funding Opportunities;Future;Goals;Individual;Infrastructure;innovation;Institution;Malignant neoplasm of prostate;member;Mentors;Mentorship;minority scientist;Monitor;outreach;Population Sciences;Positioning Attribute;Postdoctoral Fellow;pre-clinical;pre-doctoral;Process;Productivity;programs;Qualifying;racial minority;racial population;Recommendation;Records;recruit;Research;Research Personnel;Resource Development;Resources;senior faculty;Senior Scientist;Specialized Program of Research Excellence;success;symposium;System;Talents;translational cancer research;Translational Research;translational scientist;Universities;Woman;Work

PROJECT_TITLE: Career Enhancement Program (CEP)


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE – OVERALL The Salk Basic Laboratory Cancer Center is a world leader in cancer research, focusing on foundational science in cancer biology and translating discoveries to benefit patients, while training a diverse generation of cancer researchers. The Salk Cancer Center has two Research Programs: Genome Stability, Epigenetics & Aging in Cancer; and Tumor Immunology, Metabolism & Therapeutics. The Programs are supported by seven highly innovative Shared Resources providing members access to cutting-edge technologies, services, and expertise.

PI_NAMEs: SHAW, REUBEN  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Achievement;Address;Aging;anti-cancer research;Area;Awards and Prizes;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;Cancer Patient;cancer prevention;cancer research center director;Cancer Research Project;Cells;Clinical;Collaborations;computing resources;Decision Making;Dedications;DNA Damage;Doctor of Philosophy;empowerment;Endowment;Ensure;Environment;Epigenetic Process;Equity;Faculty;Fostering;Foundations;Fund Raising;Funding;Future Generations;Gene Expression;Generations;Genome Stability;Goals;Grant;Health;Immune;Immunology;Inflammation;innovation;interdisciplinary collaboration;Laboratories;Leadership;Life;Malignant Neoplasms;member;Mentors;Metabolism;Mission;multidisciplinary;Names;NCI Center for Cancer Research;new technology;next generation;Patients;Physiological;Positioning Attribute;Privatization;Process;Productivity;programs;repaired;Research;Research Institute;Research Personnel;Research Support;Resource Sharing;Resources;Running;Science;Scientist;Secure;Services;Signal Transduction;Strategic Planning;Stress;success;Technology;Textiles;Therapeutic;Thinking;Training;Training and Education;Training Programs;Translating;Translational Research;Translations;treatment response;tumor heterogeneity;tumor immunology;tumor progression;Work

PROJECT_TITLE: Cancer Center Support Grant (CCSG)


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Accounting;anti-cancer research;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer research center director;Collaborations;Communication;Communities;Complex;Contracts;COVID-19 pandemic;Data Analytics;Decision Making;Development;diversity and equity;Doctor of Philosophy;Education;Education and Outreach;Electronic Mail;Environment;Equipment;equity, diversity, and inclusion;Evaluation;Event;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;Guidelines;Human Resources;improved;Information Technology;Infrastructure;Investments;Leadership;Maintenance;Malignant Neoplasms;meetings;member;Mission;Monitor;NCI Center for Cancer Research;Occupational activity of managing finances;operation;Outcome;outreach;Participant;payment;Personnel Management;Policies;Postdoctoral Fellow;pre-doctoral;Preparation;Procedures;Process;Productivity;programs;Publications;Ramp;recruit;Reporting;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Running;Science;Services;Strategic Planning;Structure;System;Systems Development;Technology;technology development;Training;Training and Education;Translational Research;Vision;web site;Work

PROJECT_TITLE: Administration (ADMIN)


PI_NAMEs: WAHL, GEOFFREY MYLES (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;bench to bedside;Cancer Center;Cancer Center Support Grant;cancer research center director;Cancer Science;career;Chalk;Clinical;Collaborations;Communication;Communities;Complex;Consultations;Coordination and Collaboration;County;Creativeness;Dedications;design;Development;Education;Education and Outreach;education evaluation;Educational workshop;Ensure;Epigenetic Process;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Extramural Activities;Faculty;Fellowship;Funding;Funding Opportunities;Future;Goals;graduate student;Grant;high school;High School Student;improved;Individual;Informatics;Institution;Instruction;Interview;K-12 student;Laboratories;Leadership;lectures;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Metabolic;Methods;Microscopic;Minority;Mission;Molecular;NCI Center for Cancer Research;neoplasm immunotherapy;Outcome;outreach;outreach program;Phase;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Process;Professional Competence;professor;Program Development;programs;Recommendation;Research;research and development;Research Personnel;Resource Sharing;Resources;response;Rotation;Schedule;Schools;Scientific Advances and Accomplishments;Scientist;senior faculty;Series;skills;social media;Strategic Planning;Students;Study Section;success;Techniques;Technology;Therapeutic;Time;tool;Training;Training and Education;training opportunity;Training Programs;transcriptomics;Translational Research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Woman;Work;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination (CRTEC)


PI_NAMEs: LYUMKIS, DMITRY  (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Awareness;Cancer Center;Cancer Center Support Grant;Climate;Communication;Communities;Community Actions;community engagement;Consultations;Development;Discipline;Doctor of Philosophy;Elements;Employee;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;experience;Faculty;Fostering;Funding;Funding Agency;Funding Opportunities;Future;Goals;Health;high school;Human Resources;improved;Infrastructure;innovation;Institution;interest;Investments;Lead;Leadership;Malignant Neoplasms;meetings;member;Modeling;next generation;Occupations;Outcome;outreach;Philanthropic Fund;Play;Positioning Attribute;Privatization;Procedures;Process;programs;Recommendation;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Support;Resources;Role;Rotation;Schedule;Science;scientific organization;Secure;Series;social cooperation;social engagement;Societies;STEM career;STEM field;Strategic Planning;Surveys;symposium;Time;Training;Training and Education;undergraduate student;Weight;Work

PROJECT_TITLE: Plan to Enhance Diversity (PED)


PROJECT_TERMS: Acceleration;anti-cancer research;Area;Award;Basic Science;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;Cell Therapy;Collaborations;Communities;Computational Biology;Coupled;Data;Development;Drug resistance;Evolution;Faculty;Faculty Recruitment;Feedback;Funding;Goals;Grant;innovation;Institution;Investments;Malignant Neoplasms;member;NCI Center for Cancer Research;Physicians;Pilot Projects;pre-clinical;Productivity;programs;Records;recruit;Research;Research Personnel;Research Project Grants;Scientist;Strategic Planning;success;Translational Research;tumor;tumor heterogeneity;Vision

PROJECT_TITLE: Developmental Funds (DEVFUNDS)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Applications Grants;Area;Benchmarking;Cancer Biology;Cancer Center;Cancer Center Support Grant;clinical application;cohesion;Communication;Communities;Decision Making;Development;Doctor of Philosophy;Education;Elements;Ensure;Evaluation;Faculty;Feedback;Female;Fostering;Funding;gender equality;Goals;Grant;Growth;improved;innovation;interdisciplinary collaboration;Investments;Lead;Leadership;Malignant Neoplasms;member;Minority Groups;Mission;Monitor;multidisciplinary;NCI Center for Cancer Research;next generation;outreach;Play;Process;professor;programs;recruit;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Rest;Role;Strategic Planning;success;Talents;Training;Training Activity;Training and Education;Translating;Translational Research;Underrepresented Minority;Vision;Woman;Work

PROJECT_TITLE: Leadership, Planning, and Evaluation (LPE)


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: SHADEL, GERALD  (contact)

PROJECT_TERMS: Acceleration;acronyms;Advisory Committees;Aging;anti-cancer research;Bioinformatics;Bioinformatics Shared Resource;Biophotonics;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;Cancer Patient;Capital;Cells;Charge;Collaborations;Competence;Consultations;cost effective;cost efficient;Cryoelectron Microscopy;data acquisition;Data Analyses;data hub;data management;Data Storage and Retrieval;Dedications;design;DNA Damage;education resources;Ensure;Environment;Epigenetic Process;equipment acquisition;Evaluation;Evolution;Experimental Designs;Faculty;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Future;Genes;Genome Stability;Genomics;Grant;Head;Health;Human Resources;Immune;improved;Individual;Inflammation;Infrastructure;innovation;Institution;instrumentation;Investments;Laboratory Research;Leadership;Maintenance;Malignant Neoplasms;mass spectrometry shared resource;Mass Spectrum Analysis;meetings;member;Metabolism;nano-string;new technology;next generation sequencing;Occupational activity of managing finances;Office of Administrative Management;operation;Operations Research;Personnel Management;Physiological;Policies;Positioning Attribute;Process;programs;Publications;Recording of previous events;repaired;Research;Research Personnel;Resource Sharing;Resources;Services;Signal Transduction;Standardization;Strategic Planning;Stress;Surveys;Technology;technology platform;Therapeutic;Training;Training Activity;Training and Education;transcriptomics;Transgenic Organisms;treatment response;tumor heterogeneity;tumor immunology;tumor progression;Viral Vector;Voting Right;Work

PROJECT_TITLE: Shared Resource Management (SRM)


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Biological Assay;biological systems;Biophotonics;Cancer Center;Cancer Center Support Grant;Computer software;Coupled;Data Analyses;Educational workshop;Electron Microscope;Electron Microscopy;experimental analysis;Experimental Designs;Funding;high resolution imaging;Image;Image Analysis;image processing;Imaging technology;instrumentation;Light;Light Microscope;light microscopy;live cell imaging;Machine Learning;member;Methodology;Microscope;microscopic imaging;Microscopy;Morphology;Preparation;protein distribution;Reagent;Research Personnel;Resource Sharing;Sampling;Series;Specialist;superresolution microscopy;Techniques;Technology;Tissue Expansion;Tissue imaging;Tissues;Training;Visualization

PROJECT_TITLE: Advanced Biophotonics Core (BPHO)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: ZHENG, YE  (contact)

PROJECT_TERMS: Animal Model;anti-cancer research;assay development;Back;Cancer Center;Cancer Center Support Grant;Cancer Model;Categories;Cell Nucleus;Cell Separation;cell type;Cells;Charge;collaborative environment;Color;Complex;Consultations;Data Analyses;Dedications;design;disease model;Education;Ensure;experience;Experimental Designs;experimental study;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Fostering;implantation;instrument;instrumentation;Label;member;NCI Center for Cancer Research;new technology;next generation sequencing;Organelles;particle;preservation;Protocols documentation;Research;research and development;Research Personnel;Resources;sample fixation;Sampling;Scientist;service utilization;Services;single cell sequencing;Sorting;Target Populations;Techniques;Technology;Time;Training;Transplantation;trend;tumor heterogeneity;tumor microenvironment

PROJECT_TITLE: Flow Cytometry Core (FCC)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MCVICKER, GRAHAM  (contact)

PROJECT_TERMS: Accounting;Achievement;analysis pipeline;Big Data;Bioinformatics;Bioinformatics Shared Resource;Biological;Biology;Cancer Center;Cancer Center Support Grant;Computer software;Custom;Data;Data Analyses;Data Display;data mining;Data Set;Experimental Designs;genome analysis;genome sequencing;Genomics;Goals;Grant;insight;Manuscripts;member;metabolomics;NCI Center for Cancer Research;next generation sequencing;Pathway Analysis;Procedures;Proteomics;Publications;Research;Research Personnel;Resource Sharing;service utilization;Services;Techniques;tool;Training;Visualization

PROJECT_TITLE: Integrative Genomics and Bioinformatics Core (IGC)


PI_NAMEs: SAGHATELIAN, ALAN  (contact)

PROJECT_TERMS: Amino Acids;Applications Grants;Bile Acids;Cancer Center;Cancer Center Support Grant;Complex Mixtures;Consultations;data acquisition;Data Analyses;data visualization;design;Ensure;experience;Experimental Designs;experimental study;Fatty Acids;instrument;instrumentation;lipidomics;Manuscripts;mass spectrometry shared resource;Mass Spectrum Analysis;member;Metabolic;metabolomics;NCI Center for Cancer Research;new technology;Peptides;Post-Translational Protein Processing;Preparation;Protein Secretion;Proteins;Proteomics;Reproducibility;Research Personnel;Resource Sharing;Resources;Role;Sampling;Services;small molecule;Spectrometry;Training;Training and Education

PROJECT_TITLE: Mass Spectrometry Core (MASS)


PI_NAMEs: EVANS, RONALD M (contact)

PROJECT_TERMS: anti-cancer research;Basic Science;Biological;Biological Assay;Cancer Center;Cancer Center Support Grant;Cells;cost effective;Custom;Data;design;digital;DNA;DNA Sequencing Facility;Doctor of Philosophy;Ensure;experimental study;Faculty;Gene Expression Profiling;Genomics;Goals;Grant;instrument;instrumentation;Libraries;member;Methods;Mission;NCI Center for Cancer Research;next generation sequencing;novel;Publications;Quality Control;qubit;recruit;Reporting;Research;Research Design;Research Personnel;Resource Sharing;RNA;Sampling;Services;single cell genomics;skills;Technology;Tissues;Training;transcriptomics;Translational Research;Translations;Work

PROJECT_TITLE: Next Generation Sequencing Core (NGS)


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PROJECT_TERMS: blastocyst;Cancer Center;Cancer Center Support Grant;Cell Line;Charge;Consult;Consultations;cost;cost effective;CRISPR/Cas technology;Cryopreservation;Derivation procedure;design and construction;DNA;DNA Sequence Alteration;Education;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;ES Cell Line;Evolution;experience;Fertilization in Vitro;follow-up;Funding;Gene Targeting;Genes;Genetic Models;Genetically Engineered Mouse;genome editing;Goals;Group Meetings;homologous recombination;human embryonic stem cell line;human model;IACUC;Immunodeficient Mouse;Individual;induced pluripotent stem cell;Injections;innovation;Institution;Knock-out;Knockout Mice;Knowledge;Lentivirus Vector;Malignant Neoplasms;member;Microinjections;Mission;model development;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;Preparation;Research;Research Personnel;Resource Sharing;Resources;Services;Source;sperm cryopreservation;stem cell expansion;success;Techniques;Technology;Teratoma;Testing;Therapeutic Intervention;tool;Training;Transgenic Mice;Transgenic Organisms;vector;Vision;web site

PROJECT_TITLE: Transgenic Core (TGC)


PI_NAMEs: HUNTER, TONY R. (contact)

PROJECT_TERMS: adeno-associated viral vector;Adenovirus Vector;Animals;anti-cancer research;Archives;Cancer Center;Cancer Center Support Grant;Cell Physiology;Cells;Charge;Cloning;Collaborations;Consultations;cost;cost effective;Custom;design;Development;Disease;Ensure;Gene Delivery;Genetic;Goals;In Vitro;in vivo;Institution;interdisciplinary collaboration;Lentivirus Vector;Libraries;Malignant Neoplasms;member;Methods;Mission;Molecular;Plasmids;Preparation;Process;Production;programs;Rabies;recombinant viral vector;Regenerative Medicine;Research;Research Personnel;Resource Sharing;Resources;Retroviral Vector;Safety;Scientist;Services;Stomatitis;System;Technology;Training;vector;Viral;Viral Packaging;Viral Vector;Virus;Walking

PROJECT_TITLE: Viral Vector Core (VVC)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: FLUSHING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: QUEENS COLLEGE

PHR: PROJECT NARRATIVE Autism Spectrum Disorders (ASD) are complex neurodevelopmental disorders manifested by atypical social communication and behavioral repertoire. The current studies aim to reveal how sensorimotor impairments may underlie, contribute, and regulate the neurobiology of this condition in toddlers recruited from the general population during the 2nd year of life and who were assessed for ASD vs. non-ASD outcomes during the 3rd year of life. Features of the neurobiologically grounded subtypes of ASD developed as part of this proposal will be used in future studies to predict diagnosis of neurodevelopmental disorders, in children with low-functioning form of ASD, those at risk for developing ASD, and those children with related disorders of neurodevelopment.

PI_NAMEs: DENISOVA, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 3 year old;Adolescent;Adult;Age;autism spectrum disorder;Behavioral;Birth;Brain;Brain imaging;Characteristics;Child;Classification;Clinical;Cognitive;cognitive development;cohort;Communities;Complex;Computer Models;Data;Databases;design;Development;Diagnosis;Disease;Equilibrium;Esthesia;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Future;General Population;Goals;Head Movements;Hearing;Human;Impairment;Individual;Infant;insight;kinematics;Knowledge;Language;Learning;Life;Link;Machine Learning;machine learning algorithm;male;Methods;Motor;Motor Activity;Movement;MRI Scans;National Institute of Mental Health;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Noise;novel;Outcome;Parameter Estimation;Perception;predictive signature;Probability;prospective;recruit;Research;Research Priority;Rest;Risk;Role;Scanning;Sensorimotor functions;sensorimotor system;Series;Severities;sex;Shapes;Siblings;Signal Transduction;Site;skills;Sleep;social;social communication;sound;Source;Specificity;Subgroup;System;Techniques;Testing;Theoretical model;Time;Toddler;United States National Institutes of Health;Work

PROJECT_TITLE: Investigating quantitative signatures of autism in toddlers

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]