NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer, and patients with TNBC exhibit a poor prognosis, despite current treatment regimens. Although the reasons for such poor survival outcomes remain incompletely understood, it has become clear that non-cancerous cell types within the tumor microenvironment (TME) are integral players in disease progression and resistance to diverse oncologic therapies. Here, we seek to decipher a novel biology of a previously identified oncogene known as TAZ in TNBC progression, a biology that governs the mobilization of pro-tumorigenic myeloid populations to the TME and one that also provides opportunities for novel biomarker or therapeutic target discovery.

PI_NAMEs: ABRAMS, SCOTT I.;ZHANG, JIANMIN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: adaptive immune response;Affect;angiogenesis;Antineoplastic Agents;Biological Markers;Biology;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cancer Biology;cancer cell;Cancer Etiology;CCL20 gene;Cell Death;cell type;Cells;Cessation of life;chemokine;chemotherapy;Clinical;Complex;cytokine;Cytometry;Data;Disease;Disease Progression;Disease Resistance;Distant;Distant Metastasis;Early treatment;effective therapy;Epidermal Growth Factor Receptor;Estrogen Receptors;Exhibits;follow-up;Frequencies;Genes;Genetic Transcription;Goals;high risk;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunocompetent;immunoregulation;Immunosuppression;Immunotherapy;Implant;improved;Invaded;knock-down;Knowledge;Laboratories;Link;loss of function;Malignant Breast Neoplasm;Mediating;Modeling;Molecular;molecular subtypes;mouse model;Mus;Myelogenous;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic;new therapeutic target;novel;novel marker;novel therapeutic intervention;Oncogenes;overexpression;Pathway interactions;Patients;Play;Population;pre-clinical;Pre-Clinical Model;Production;Progesterone Receptors;Prognosis;prognostic;Proliferating;public health relevance;Publishing;receptor;recruit;Recurrence;refractory cancer;Regulatory T-Lymphocyte;Research;Resistance;Role;Signal Pathway;Signal Transduction;Specimen;standard of care;survival outcome;Survival Rate;targeted treatment;Testing;therapeutic target;trafficking;Transcriptional Coactivator with PDZ-Binding Motif;Transgenic Mice;Translating;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Women's mortality

PROJECT_TITLE: Dissecting Molecular Mechanisms of Tumor-Induced Myeloid-Mediated Immune Suppression in Triple-Negative Breast Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Chronic Pain;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Although it is the most common systemic rheumatic disease in older adults, polymyalgia rheumatica (PMR) remains critically understudied. PMR is associated with persistent symptoms which also lead to prolonged use of glucocorticoids. Frailty in PMR identifies a group of patients with worse symptoms, and risk for prolonged treatment. Further understanding of the prevalence and impact of frailty can lead to the development of interventions such as physical and occupational therapy that can improve function and decrease pain, cardinal symptoms of PMR. This study proposes to utilize claims data to better understand these associations and inform the creation of future interventions to improve the care of older adults with PMR.

PI_NAMEs: SATTUI, SEBASTIAN EDUARDO (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accounting;Address;Affect;age group;Aging;Analgesics;Area;Arthritis;Automobile Driving;career;Caring;Chronic;clinical care;Clinical Trials Design;clinically relevant;clinically significant;cohort;Collaborations;Complement;Cox Proportional Hazards Models;Data;deprivation;Development;Development Plans;Diagnosis;Disease;Dose;Effectiveness;Elderly;Epidemiology;epidemiology study;Event;exercise intervention;Foundations;Frail Elderly;frailty;functional improvement;Future;Glucocorticoids;Health;health service use;Healthcare;High Prevalence;high risk;Hip Pain;immune modulating agents;improved;improved mobility;improved outcome;indexing;Individual;Inflammatory;insight;insurance claims;Intervention;joint stiffness;Knowledge;Medicare;Mentorship;Mobility decline;Modification;Morbidity - disease rate;mortality;Musculoskeletal;Newly Diagnosed;non-opioid analgesic;novel;nutrition;Occupational Therapy;older adult;Opioid;Outcome;Pain;Pain management;Patient Self-Report;Patients;persistent symptom;Personal Satisfaction;Pharmaceutical Preparations;Physical Function;Physical therapy;Polymyalgia Rheumatica;Population;prescription pain reliever;Prevalence;Productivity;Professional Organizations;Reporting;Research Personnel;Rheumatism;Rheumatology;Rhubarb food;Risk;Role;Sampling;Scientist;Services;Severities;Shoulder Pain;socioeconomics;stressor;symptomatic improvement;Symptoms;Syndrome;Testing;Therapeutic Intervention;therapy development;Time;Training;treatment duration;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Prevalence and Impact of frailty in older adults with polymyalgia rheumatica

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Non-typhoidal Salmonella infects the gastrointestinal tract and is a leading cause of morbidity and mortality worldwide. We aim to integrate multiomics approaches to elucidate new mechanisms of competition between Salmonella and the gut microbiota. Our long-term goal is to develop new prebiotics and probiotics to limit Salmonella infection.

PI_NAMEs: RAFFATELLU, MANUELA  (contact);ZENGLER, KARSTEN B

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Anaerobic Bacteria;Animals;Antibiotic Therapy;antimicrobial;Bacteria;bacterial metabolism;Bacteroidetes;Colon;colonization resistance;Communities;Data;Enterobacteriaceae;Environment;Exhibits;expectation;Family;Firmicutes;Gastrointestinal tract structure;Goals;gut colonization;gut inflammation;gut microbiota;Immune response;Immunity;In Vitro;in vivo;Individual;Infection;Inflammatory Bowel Diseases;innovation;insight;Intervention;intestinal homeostasis;Intestines;Knowledge;Lectin;member;Metabolic;metabolic profile;Metabolism;Metagenomics;metatranscriptomics;microbial;microbiota;Modeling;Morbidity - disease rate;mortality;multiple omics;Mus;non-typhoidal Salmonella;pathogen;Pathogenesis;prebiotics;preference;Probiotics;Proliferating;Proteins;Regenerating islet derived protein 3-Gamma;Research;Resistance;Resource Allocation;Resources;response;Ribosomes;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Shapes;stem;Testing;Therapeutic Intervention

PROJECT_TITLE: Applied Metatranscriptomics and Metatranslatomics to identify new mechanisms of Salmonella-microbiota competition

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative In the United States, nearly 30 million individuals reported suffering from alcohol use disorder (AUD). By investigating the activation of key brain regions and their impact on astrocyte dynamics, we seek to provide insights into potential therapeutic strategies for AUD.

PI_NAMEs: CHOI, DOO-SUP  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Alcohol consumption;alcohol seeking behavior;alcohol use disorder;Area;Astrocytes;Award;Behavior;Brain region;Calcium;career development;Clinic;Corpus striatum structure;Decision Making;Development;Dorsal;Economics;Educational workshop;Eligibility Determination;expectation;Extramural Activities;Fostering;frontal lobe;Funding;Future;Glutamates;Goals;Individual;insight;Laboratories;Learning;Medial;Mentors;Methods;Neurons;parent project;Parents;Pathway interactions;Physicians;Population;Psychopathology;Publications;Reporting;Rewards;Scientist;Structure;symposium;Therapeutic;Training;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Astrocyte-Neuron Interaction in the Dorsal Striatum and Ethanol-Seeking Behaviors Diversity supplement - Matthew Lopez

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

ORG_CITY: WESTON

ORG_NAME: MASSACHUSETTS NEURO TECHNOLOGY, INC.

ORG_STATE: MA

PHR: Narrative The aim of this study is to develop a Virtual Reality guided acupuncture imagery treatment system (prototype) for the treatment of chronic low back pain. This product will provide a new cost-effective treatment option for chronic low back pain and potentially other chronic pain disorders.

PI_NAMEs: KONG, JIAN  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Acupuncture Points;Acupuncture Therapy;American College of Physicians;Analgesics;Anterior;Attention;Benchmarking;Brain;brain pathway;Brain region;Caring;Chronic low back pain;chronic pain;chronic painful condition;cingulate cortex;Clinic;Clinical;clinical efficacy;cost effective;cost effective treatment;design;Development;disability;Esthesia;expectation;experience;Feasibility Studies;feasibility testing;General Hospitals;Goals;Gossypium;head mounted display;Home;Hospitals;Illusions;Imagery;Imagination;improved;Insula of Reil;Intervention;Investigation;Literature;Low Back Pain;Massachusetts;Medical;Medicine;mental imagery;Methods;midbrain central gray substance;Mind-Body Intervention;Modality;Nature;Needles;Neurocognitive;neurotechnology;novel;operation;Outcome;Ownership;Pain management;pain patient;pain reduction;Participant;Patients;Perception;Phase;Physicians;Pilot Projects;preference;primary outcome;Privatization;Property;prototype;Randomized;Recommendation;Recording of previous events;recruit;reduce symptoms;Research;Research Personnel;retention rate;Safety;satisfaction;secondary outcome;simulation;Small Business Technology Transfer Research;Swab;System;Testing;Therapeutic;Therapeutic Effect;Time;tool;Touch sensation;Training;Treatment Efficacy;two-dimensional;Video Recording;virtual reality;virtual reality environment;Visit;Visualization;Work

PROJECT_TITLE: Developing a virtual reality guided acupuncture imagery treatment for Chronic low back pain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Narrative: Black and Latinx adults bear a disproportionate share of the burden of disease from asthma but attempts at reducing this disparity have mostly been unsuccessful partly due to an insufficiently understood relationship with social determinants of health (SDOH). Our group demonstrated in a large pragmatic clinical trial (the PREPARE study) that a ‘Patient-Activated, Reliever-Triggered Inhaled CorticoSteroid’ (‘PARTICS’) strategy added to usual care successfully reduced asthma attacks in 1,201 Black and Latinx adults with moderate-severe asthma relative to usual care, and in doing so created a rich dataset of demographic, clinical, and phenotypic data, now enhanced with geocoding data available from participants’ zip codes—a wealth of data on two racial and ethnic groups for whom there is few clinical research studies available. We now have an opportunity with the richness of our dataset to identify unique sets of SDOH characteristics for Black and Latinx adults that may lead to high-yield interventions, plus facilitate our work implementing the PARTICS strategy, both of which may reduce morbidity in these two highly impacted populations.

PI_NAMEs: CARDET, JUAN CARLOS (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adult;Affect;African American;Airway Disease;American;Asthma;asthma exacerbation;Black American;Black race;built environment;burden of illness;Caribbean region;Characteristics;Child;Chronic;chronic respiratory disease;Clinical;Clinical Data;Clinical Research;clinically significant;cohort;Collection;Communities;Complex;Data;Data Set;Development;Dimensions;disparity reduction;Economics;Education;education access;Emergency department visit;Equation;Ethnic Population;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;health care availability;Health Care Costs;Hospitalization;improved;Individual;inequitable distribution;Inflammatory;Inhalation;Intervention;Knowledge;Latinx;low socioeconomic status;Manuscripts;Measures;Mediation;Modeling;Morbidity - disease rate;Neighborhoods;Outcome;Participant;Pathway interactions;Patients;phenotypic data;Policies;Population;Positioning Attribute;Poverty;Pragmatic clinical trial;prospective;Quality of life;racial population;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;research study;Severities;social;social health determinants;Socioeconomic Status;Subgroup;Surveys;Testing;Therapeutic;treatment as usual;treatment responders;treatment response;Unemployment;United States;usual care arm;Vulnerable Populations;Work

PROJECT_TITLE: Social Determinants of Health, Asthma-Related Morbidity and Therapeutic Optimization for Black and Latinx Adults with Asthma

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RELEVANCE In response to RFA AG-24-050, this project will estimate the costs and benefits of new disease-modifying drugs for African American and white Alzheimer’s disease patients in a state socio-economically disadvantaged. Results will lead to recommendations for equitable use of new drugs to improve the life of diverse older adults with this disease. This project is, thus, relevant to the ultimate goal of the National Institute of Aging of supporting research on aging and the health and well-being of older people to extend healthy, active years of life.

PI_NAMEs: PISU, MARIA  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adherence;Affect;African American;African American population;Aging;Alabama;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;American;base;Brain imaging;Caregivers;Characteristics;Clinic;Clinical;Cognitive;Collaborations;community engagement;copayment;cost;cost effectiveness;cost estimate;Costs and Benefits;Data;Data Collection;Deep South;Disadvantaged;Disease;disease disparity;Disease Outcome;drug distribution;Drug usage;Drug Utilization;economic disparity;economic evaluation;Economic Models;Eligibility Determination;Equity;experience;experimental study;Exposure to;Focus Groups;Goals;Health;health equity;Health Services Accessibility;human old age (65+);Image;improved;Infusion procedures;Intervention;Interview;intravenous administration;Intravenous infusion procedures;Knowledge;Life;Literature;markov model;Medical;Medical Records;Methods;Modeling;mortality;National Institute on Aging;Neurologist;novel therapeutics;older adult;Older Population;Outcome;outcome disparities;Patients;Performance;Personal Satisfaction;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Population;Population Heterogeneity;preference;productivity loss;Provider;Psychiatrist;Publishing;Quality of life;Questionnaires;Recommendation;Research Support;Resources;Respondent;response;Running;Schedule;Services;side effect;socioeconomic disadvantage;Source;Specialist;Structure;supportive environment;Surveys;Transportation;Travel;Universities;US State;Visit;Voice;Work

PROJECT_TITLE: EQUITY IN ACCESS TO ALZHEIMER'S DISEASE PHARMACOLOGIC TREATMENT FOR AFRICAN AMERICAN AND WHITE PATIENTS IN ALABAMA  A MIXED METHODS STUDY TO INFORM RECOMMENDATIONS EquAAL

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M4)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Dietary Supplements;Health Effects of Indoor Air Pollution;Maternal Health;Nanotechnology;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The utero-placental circulations are specifically designed to regulate the flow of blood and transport of essential nutrients to the fetus; this coordinated exchange is highly susceptible to disruption from environmental exposure, which can result in miscarriage and intrauterine growth restriction (IUGR). Unfortunately, the vascular and endothelial-dependent mechanisms by which utero-placental blood flow is reduced in IUGR are unknown, resulting in few treatment options beyond preterm delivery. We will use our model of environmentally-inducible IUGR to reveal novel mechanisms of altered hemodynamic molecular signaling that contribute to the development of IUGR as well as test nutritional interventions to mitigate IUGR severity.

PI_NAMEs: STAPLETON, PHOEBE  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: absorption;Acute;Aerosols;Air Pollution;Airborne Particulate Matter;Animals;Arachidonic Acids;arteriole;Attenuated;Biological Availability;Blood flow;Blood Vessels;Cardiovascular Diseases;Child;Chronic;Circulation;Clinical;constriction;cost;Data;Decidua Basalis;design;Development;dietary;Dietary Intervention;Diffusion;Dose;Eicosanoids;Endothelial Cells;Endothelium;Environment;Environmental Exposure;epidemiology study;Epoprostenol;Equilibrium;Evaluation;exhaust;Exposure to;fetal;fetal blood;Fetal Death;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal health;fetal loss;Fetal Malnutrition;Fetal Weight;Fetus;fetus hypoxia;fine particles;folic acid metabolism;folic acid supplementation;Gases;Generations;Goals;Growth;healthy pregnancy;hemodynamics;Impairment;improved;In Vitro;Inhalation;innovation;insight;Intervention;intravital microscopy;Laboratories;late life;Left;Low Birth Weight Infant;Maternal Exposure;Maternal-fetal medicine;mechanical signal;Metabolic Diseases;Metabolism;Methodology;Microvascular Dysfunction;Modeling;Molecular;Mothers;Myography;nano;nanomaterials;nanosized;neonatal morbidity;Neonatal Mortality;Nitric Oxide;novel;novel strategies;Nutrient;Oxygen;particle;Particulate;Particulate Matter;Pathogenesis;patient population;Patients;Perfusion;pharmacologic;Pharmacological Treatment;Physiology;Placenta;Placental Circulation;Predisposition;Pregnancy;pregnant;Pregnant Women;Premature Birth;Preparation;pressure;prevent;Production;Prostaglandins I;Qualifying;Rattus;Regulation;Research;Resources;response;Risk;Risk Factors;Rodent Model;Role;Severities;Signal Transduction;skills;Spontaneous abortion;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thromboxane A2;titanium dioxide;Toxic effect;Toxic Environmental Substances;Toxicant exposure;Treatment Efficacy;ultrafine particle;Uteroplacental Circulation;Uterus;Vascular Endothelium;vasoconstriction;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Microvascular mechanisms of growth restriction after environmental toxicant exposure


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The development of therapeutic RNAi which reduces expression of both normal and mutant alleles is not appropriate in many cases for dominantly inherited disorders. As such, there is a dire need to develop mutant-specific RNAi as a therapeutic treatment for such diseases. Here, we will execute the comprehensive development of a novel approach for the allele-specific knockdown for mutations in the TARDBP and KIF5A genes which are causative for ALS/FTD.

PI_NAMEs: LANDERS, JOHN E (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adult;Alleles;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Base Pairing;causal variant;Cell Physiology;Cessation of life;Complex;Defect;design;Development;Discrimination;Disease;dominant genetic mutation;Dominant-Negative Mutation;familial amyotrophic lateral sclerosis;Family;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Gene Delivery;Gene Expression;Gene Mutation;gene therapy;Genes;Hereditary Disease;Homodimerization;human disease;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;knock-down;loss of function;loss of function mutation;Methods;Modification;Motor Neuron Disease;Muscular Atrophy;mutant;Mutate;Mutation;Neurodegenerative Disorders;Neurons;novel;novel strategies;nucleocytoplasmic transport;Pathogenesis;Pathogenicity;protein aggregation;protein TDP-43;Proteins;Recording of previous events;Research Personnel;RNA;RNA Interference;RNA Interference Therapy;RNA Splicing;Small Interfering RNA;sporadic amyotrophic lateral sclerosis;Structure;Technology;Testing;Therapeutic;therapeutic development;therapeutic gene;Toxic effect;transcriptome sequencing;viral gene delivery

PROJECT_TITLE: Development of Mutant Specific Antisense Oligonucleotides for TARDBP and KIF5A as a Therapeutic for ALS/FTD

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Common acquired or congenital airway abnormalities in children, such as subglottic stenosis (SGS), Robin sequence (PRS), and tracheobronchomalacia, are typically assessed using semi-quantitative measures. Normative data can be used to establish quantitative measures of airway abnormality, but existing normative models do not fully assess airway geometry as they only consider airway cross-sectional area. This project will therefore develop a pediatric airway shape atlas to better capture 3D airway geometry and will explore its utility for predicting airway development and to assess airway abnormalities in children with subglottic stenosis and Robin sequence.

PI_NAMEs: NIETHAMMER, MARC  (contact);ZDANSKI, CARLTON J

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Admission activity;Adult;Affect;Age;Aging;airway obstruction;Anatomy;Area;Atlases;Automation;Breathing;Bronchoscopy;Caring;Cessation of life;Child;Childhood;Clinical;Clinical Data;Complex;Computer software;Computing Methodologies;Data;Data Analyses;Data Set;Databases;deep learning;design;Detection;Development;Diagnosis;Disease;Disease stratification;Ensure;Event;expectation;experience;General Anesthesia;Geometry;Goals;Growth;Heart Diseases;Hematological Disease;Hypoxia;Image;improved;Individual;innovation;interdisciplinary approach;Intubation;Knowledge;Life;Lung Diseases;Manuals;Measures;Medical;Medical center;Methodology;Methods;Modeling;Morbidity - disease rate;Neonatal;neural;new technology;Normal Range;Normal Statistical Distribution;Obstructive Sleep Apnea;open source;Operative Surgical Procedures;Outcome;Patient observation;Patients;Pediatric Hospitals;Physiological;Population;preference;Prevalence;radiological imaging;Recommendation;recurrent infection;Research;Respiratory Insufficiency;response;Risk;Robin bird;secondary analysis;sex;Shapes;Site;Sleep Disorders;Stenosis;Technology;Time;Tracheobronchomalacia;treatment planning;Weight;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Pediatric Atlas of Upper Airway Shape

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative This application investigates whether PSPC1 inhibition represents a safe and highly effective therapeutic strategy for AML in which PSPC1 interacts with key transcription factors to dictate a unique leukemic transcription program underlying various subentities of AML. The proposed studies could establish PSPC1 as a critical and novel determinant of AML leukemogenesis, which can lead to a breakthrough in AML treatment.

PI_NAMEs: WANG, JIANLONG ;XU, MINGJIANG  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Animal Model;Apoptosis;Behavior;Binding;Biological Assay;Biology;C-terminal;CD34 gene;Cell Differentiation process;Cell Line;Cell model;Cells;Characteristics;ChIP-seq;Chromatin;Coiled-Coil Domain;Collaborations;Competence;Complementary DNA;Coupled;Data;Dimerization;Doxycycline;Drosophila genus;FLT3 gene;Functional disorder;gain of function;Gene Expression Regulation;gene repression;Genes;genetic approach;Genetic Transcription;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;knock-down;Knock-in;Knock-out;Knockout Mice;Knowledge;leukemia;leukemia treatment;leukemogenesis;loss of function;Maintenance;Mediating;member;MLL-AF9;MLL-rearranged leukemia;Modeling;Molecular;Molecular Target;mouse development;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;N-terminal;new therapeutic target;novel;NPM1 gene;Nuclear;Oncogenes;Organ;overexpression;Pathogenicity;Pathologic;Patients;Play;Pluripotent Stem Cells;programs;Proliferating;Protein Family;Protein Splicing;Proteins;Proteomics;Reporting;RNA;RNA Interference;Role;RUNX1 gene;self-renewal;small molecule inhibitor;Solid Neoplasm;stem;stem cell function;stemness;success;Testing;Therapeutic;therapeutically effective;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumorigenesis;virtual;Xenograft procedure

PROJECT_TITLE: Therapeutic value and mechanistic action of PSPC1 in AML

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The Northwestern genetics-enabled learning health system (Northwestern gLHS) brings together a team of investigators with expertise in learning health systems, implementation science, and cardiovascular and cancer genetics. We will design, implement, and continuously refine strategies and resources to enhance equitable genetic medicine among diverse populations. We propose 3 projects on cascade genetic testing (CGT) for hereditary conditions within cardiovascular disease and cancer as our use case to address different aspects of a primary barrier in CGT, overreliance on probands to transmit the importance of CGT to family members.

PI_NAMEs: BEIDAS, RINAD SARY;FRANKLIN, PATRICIA D (contact);GODLEY, LUCY ANN;MCNALLY, ELIZABETH M

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academy;Acceleration;Address;African American;Arrhythmia;Asian;Asian Americans;Biological;Black American;cancer genetics;cancer risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care delivery;care outcomes;Caring;cascade genetic testing;Cessation of life;Clinical;clinical decision support;clinical research site;cohort;Collaborations;Communities;Community Networks;community partners;community partnership;community setting;Computerized Medical Record;cost;cost effective;Country;Coupled;data management;Data Reporting;design;Development;Devices;Diagnosis;Disease;Disparity;Distant;Electronic Health Record;Ensure;Environment;Equitable healthcare;Equity;Ethnic Origin;Evaluation;evidence base;evidence based guidelines;Evidence based practice;experience;Faculty;Familial Hypercholesterolemia;Family member;Federally Qualified Health Center;follow-up;Future;Genetic;Genetic Diseases;genetic information;Genetic Medicine;Genomics;Germ Lines;Guidelines;Health;health care delivery;health care disparity;health care settings;health management;Health system;Healthcare;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Nonpolyposis Colorectal Neoplasms;implementation science;improved;improved outcome;indexing;Individual;Infrastructure;Inherited;Institution;Investments;Knowledge;Laboratories;Latino;Lead;Learning;Li-Fraumeni Syndrome;lipid disorder;Malignant Neoplasms;Medical;Medicine;member;Methods;Mission;Monitor;Morbidity - disease rate;National Human Genome Research Institute;Neighborhood Health Center;Notification;novel;Operative Surgical Procedures;Outcome;Patients;Pilot Projects;Play;Population Heterogeneity;Populations at Risk;Precision Health;premature;proband;Race;Recommendation;recruit;Reporting;Research;Research Personnel;Resources;Risk Assessment;Scientist;screening;Societies;System;Technology;testing uptake;theories;tool;transmission process;uptake;Vascular Diseases;Voice;web-based tool;willingness;Work;World Health

PROJECT_TITLE: Transforming health at the intersection of implementation science, learning health systems, and genomics at Northwestern Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Bone marrow stem cell transplantation is widely used in the clinic to treat blood diseases. This proposal intends to identify novel regulators of bone marrow regeneration controlling communication between cells in the bone marrow and determine new rationally designed approaches to optimize stem cell transplantation.

PI_NAMEs: CANCELAS, JOSE A. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adenosine Monophosphate;Area;Behavior Therapy;Biology;Blood Vessels;Bone Marrow;Bone Marrow Stem Cell Transplantation;Cell Communication;Cell Physiology;Cells;Chimerism;Clinic;Communication;conditioning;Connexin 43;Coupling;Data;design;Gene Expression Profile;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic hierarchy;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic transplantation;improved;interest;irradiation;Mediating;Mesenchymal;Metabolic;Metabolism;Mitochondria;Molecular;mutant;Mutation;Myeloablative Chemotherapy;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;novel;Oxidative Stress;Pathologic;Phosphotransferases;Population;Protocols documentation;Publishing;rational design;Recommendation;Recovery;regenerative;Regulation;Role;sensor;stem;stem cell fate;stem cell niche;Stem cell transplant;stem cells;Supporting Cell;System;Text

PROJECT_TITLE: Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (03)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Although a wide panel of genetically manipulated mouse strains have made significant contributions in increasing our understanding of the molecular and genetic bases of periodontitis that affects over 46% of the U.S. adult populations (>30y), mouse biological systems don't completely duplicate that of human. This study is intended to develop a humanized mouse model of periodontitis, so that possible pathological effect of human Semaphorin 4D expressed on human osteoclasts in the dysregulated bone remodeling in periodontitis, is evaluated in the physiological context. This emerging technology of “humanized mice”, i.e., immunodeficient mice engrafted with functional human cells and tissues, offers a great opportunity to examine the questions that can't be addressed using human subjects, conventional tissue culture system or animal model.

PI_NAMEs: KAWAI, TOSHIHISA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Address;Adult;Affect;alveolar bone;Alveolar Bone Loss;Animal Model;Antigen-Presenting Cells;Applications Grants;autocrine;axon growth;B-Lymphocytes;base;Behavior;Biological;biological systems;Blood Platelets;bone;bone loss;Bone Marrow Ablation;Bone remodeling;Bone Resorption;CD100 antigen;CD14 gene;Cell Lineage;Cell Separation;Cells;conditioning;Cyclophosphamide;cytokine;Data;Deposition;Dichloromethylene Diphosphonate;differential expression;Disease;Down-Regulation;efficacy evaluation;Emerging Technologies;Engraftment;Enterococcus faecalis;Enzyme-Linked Immunosorbent Assay;examination questions;Excision;Gene Expression;Genetic;genetic manipulation;Gingiva;Grant;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;human disease;human induced pluripotent stem cells;human subject;humanized mouse;Immune;Immune response;Immune system;Immunocompromised Host;Immunodeficient Mouse;Immunohistochemistry;in vivo;in vivo imaging;Individual;induced pluripotent stem cell;Inflammatory;Insulin-Like Growth Factor I;interest;Interleukin-1 beta;Interleukin-6;Intervention;irradiation;Label;Lesion;Ligature;Liposomes;Liquid substance;Lymphocyte;Lymphoid Cell;Lytic;Malignant Bone Neoplasm;Measurement;Measures;Mediating;Metastatic Neoplasm to the Bone;Modeling;Molecular;Monitor;Monoclonal Antibodies;monocyte;mouse model;Mouse Strains;Mus;Myeloid Cells;Natural regeneration;next generation;novel;Oral;oral pathogen;Organoids;Osteitis;Osteocalcin;Osteoclasts;osteoimmunology;Osteoporosis;Outcome;Ovariectomy;Pathogenicity;Pathologic;Patients;Periodontitis;periodontopathogen;Pharmacology Study;Physiological;Population;Porphyromonas gingivalis;pre-clinical;precision medicine;Preclinical Testing;Predisposition;Production;Property;Protocols documentation;Publishing;Reaction;receptor;Reporting;response;Rest;Rodent;Role;single-cell RNA sequencing;Stimulus;Study models;System;Systemic disease;T-Lymphocyte;Technology;Testing;The Jackson Laboratory;Thymus Gland;Time;tissue culture;Tissues;TNF gene;tool;transcription factor;Transplantation;Up-Regulation

PROJECT_TITLE: Humanized mouse model of periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Data Science;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The major goal of the FaceBase data resource is to advance the impact of research into Dental, Oral and Craniofacial health and disease on improving human health. We will acomplish this by expanding the the scope and scale of the existing FaceBase data repository resource to include research across all of DOC research and across the translational spectrum, from basic research to clinical applications.

PI_NAMEs: CHAI, YANG ;KESSELMAN, CARL  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Advisory Committees;Anatomy;Animal Model;Basic Science;Behavioral Research;Biomedical Research;Cells;clinical application;Collaborations;Communication;Communication impairment;Communities;Community Outreach;computer framework;computer scientist;Congenital Abnormality;cost effective;craniofacial;Craniofacial Abnormalities;craniofacial development;cranium;Data;data access;data curation;data integration;data management;data repository;data resource;data reuse;Data Science;Data Set;data sharing;data submission;data visualization;Dental;Development;digital repositories;Dimensions;Discipline;Disease;Dysmorphology;education resources;empowerment;Ensure;Environment;Ethics;experience;experimental study;Face;FaceBase;FAIR principles;flexibility;Fostering;Funding;Genetic;Genetic Diseases;Goals;Health;high standard;Human;human data;human model;Image;improved;Infrastructure;Institution;interoperability;large language model;Life Cycle Stages;Mission;Modeling;National Institute of Dental and Craniofacial Research;Neurologic;operation;Oral;Oral health;Other Genetics;outreach;Personal Satisfaction;Persons;Phase;Phenotype;Play;Policies;Population;Privacy;Process;Public Health;Publications;quality assurance;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;skills;Structure;success;synergism;tool;Training;translational pipeline;Translational Research;TRUST principles;trustworthiness;Underrepresented Populations;United States National Institutes of Health;virtual

PROJECT_TITLE: USC Facebase IV Craniofacial Development and Dysmorpholoy Data Management and Integration Hub (FaceBase IV))

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (55)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: FORT WASHAKIE

ORG_NAME: EASTERN SHOSHONE TRIBE

ORG_STATE: WY

PI_NAMEs: HIRCHAK, KATHERINE ;WEBB, KELLIE  (contact)

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: Abstinence;Address;Adult;Alaska Native;Alcohols;Ambulatory Care;American Indians;Anxiety;Area;Colonialism;Communities;Data;data submission;Educational process of instructing;Emotional;Environment;Epidemic;Equilibrium;Evaluation;evidence base;Evidence based practice;experience;Family;Feasibility Studies;Future;Harm Reduction;healing;health inequalities;implementation barriers;Indigenous;Indigenous Medicine;Individual;Infrastructure;innovation;interest;Intervention;Life;Measures;Medicinal Plants;Medicine;Mental Depression;Methamphetamine;Modeling;Naloxone;Not Hispanic or Latino;Opioid;opioid epidemic;opioid overdose;Outcome;Pain management;Personal Satisfaction;Persons;Pharmaceutical Preparations;Productivity;Program Development;Psyche structure;Public Health;Research;Research Infrastructure;Research Proposals;Reservations;response;Rural;Seasons;Services;skills;Sleep;Spirituality;substance misuse;substance use;tribal community;United States National Institutes of Health;Well in self;Work

PROJECT_TITLE: Our Healing Journey: A Cultural and Traditional Response to the Opioid Epidemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE  Brain cancer is a leading cause of death and brain metastases represent a highly unmet clinical need. In particular, brain metastases from breast cancer are associated with dismal prognosis. This proposal seeks to elucidate the mechanisms by which breast cancer spreads to the brain, utilizing our in vivo models to evaluate brain tumor tropic genes, novel imaging methods of cellular tracking in the CNS, and ultimately development of a novel stem cell-based therapy for HER2+ brain metastases.

PI_NAMEs: LESNIAK, MACIEJ S (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: analog;Basic Science;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;breast cancer metastasis;cancer cell;Cause of Death;Clinical;Clinical Research;Development;Disease;Dissection;engineered stem cells;ERBB2 gene;Excision;experience;Genes;Genetic;Genetic Engineering;Growth;imaging modality;in vivo Model;Invaded;Malignant Breast Neoplasm;Malignant neoplasm of brain;Metastatic malignant neoplasm to brain;Monoclonal Antibodies;Neoplasm Metastasis;nerve stem cell;novel;Operative Surgical Procedures;Patients;Permeability;Prognosis;Radiation therapy;Risk Factors;Science;Scientist;stem cell delivery;stem cell therapy;targeted delivery;Therapeutic;Time;Tissues;Translational Research;Trastuzumab;Visualization;Woman

PROJECT_TITLE: Emerging Strategies for Therapy of Metastatic Brain Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Neurosciences;Patient Safety;Stroke

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative/ Relevance to Public Health Blockage of the carotid arteries by plaque can cause stroke, particularly in people over 65 years old, and surgery is often done to decrease the chance of stroke when carotid narrowing is found. The goal of this study is to see what activities are most important for older people with carotid artery disease, and how medicine or surgery can help them perform these activities. In this study, we will ask questions about how well older patients with carotid narrowing think, feel, and are able to do what makes them happy before and after surgery to see if surgery improves these things, even though surgery is performed to reduce their risk of stroke.

PI_NAMEs: JOHNSON, CALI  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Affect;affective disturbance;Aftercare;Age;Aging;Atherosclerosis;Attention;Blood Vessels;career;Caregivers;Carotid Arteries;Carotid Artery Diseases;Carotid Artery Plaques;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Cessation of life;Clinical;clinical practice;Cognition;Cognitive;cognitive function;cognitive testing;comparative effectiveness trial;Complex;Data;Decision Making;design;Development Plans;Diagnosis;Dimensions;disability;Disease;Elderly;Emotional;emotional functioning;Ensure;experience;Factor Analysis;Fatigue;Focus Groups;Foundations;Friends;Goals;Grant;Happiness;Health system;human old age (65+);Impaired cognition;implementation science;implementation trial;improved;Information Systems;instrument;Interview;K-Series Research Career Programs;Knowledge;lens;Long term disability;Measurement;Measures;Medical;Medicine;Methodology;Moods;Newly Diagnosed;novel;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Outcome Measure;Patient Monitoring;patient oriented;Patient Outcomes Assessments;patient population;Patient Preferences;Patient Selection;Patient-Focused Outcomes;Patients;Perioperative complication;personalized health care;Persons;Pharmaceutical Preparations;Physicians;poor sleep;Population;prevent;Provider;Psyche structure;Public Health;Quality of life;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Methodology;Research Priority;revascularization;shared decision making;skills;Sleep disturbances;Societies;Standardization;Stenosis;Stroke;stroke risk;stroke symptom;Structure;success;surgical research;Symptoms;Testing;Training;treatment effect;United States National Institutes of Health;Universities;Utah;Vascular Diseases

PROJECT_TITLE: Patient-Centered Outcomes in Carotid Artery Stenosis


NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Immunotherapy;Patient Safety

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The work of a Clinician Scientist, with regards to development of clinical trials, implementation of clinical trials at their institution, and leadership roles within the national cooperative groups, is invaluable to the continued success of NCI-funded clinical cancer research. This award provides salary support and sufficient autonomy such that the Clinician Scientist does not have to solely rely on NCI-funded grants held by others or other institutional sources of support in order to participate in NCI-funded clinical research. Dr. Cathy Eng is an exemplary Clinician Scientist as evidenced by her dedication to the NCI-sponsored clinical trial networks through development and leadership of clinical trials, service in leadership roles, and mentorship.

PI_NAMEs: ENG, CATHY  (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: American College of Radiology Imaging Network;anti-cancer research;Award;Cancer Center;Cancer Center Support Grant;career;checkpoint inhibition;chemotherapy;Clinical;clinical development;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Dedications;Development;DNA Markers;early-career faculty;Eastern Cooperative Oncology Group;Fellowship;Female;Funding;Future;gastrointestinal;Grant;Guidelines;insight;Institution;Investigational Therapies;Lead;Leadership;Malignant neoplasm of anus;member;Mentors;Mentorship;mid-career faculty;multidisciplinary;National Clinical Trials Network;next generation;novel;Oncology;Patients;peer;Phase;phase III trial;Refractory;Research;Role;Scientist;service engagement;Services;Site;Source;Southwest Oncology Group;success;tumor DNA;Wages;Work;working group

PROJECT_TITLE: Cultivating programmatic efforts to optimize the conduct and implementation of NCI-funded clinical trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE  Emerging and re-emerging respiratory viruses are a significant threat to public health and the global economy. While a dysregulated immune response is believed to cause acute lung injury and severe pneumonia following SARS-CoV-2 and other pathogenic human coronavirus infections, the basis for such deleterious host response is not well understood. Here, we will investigate the role of myeloid cell-intrinsic TLR-TRAF6 activation in causing SARS-CoV-2-induced lethal lung disease and define the mechanistic basis for TRAF6-mediated dysregulated immunity.

PI_NAMEs: CHANNAPPANAVAR, RUDRAGOUDA  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Abbreviations;Acute Lung Injury;Adrenal Cortex Hormones;Affect;antagonist;Anti-viral Response;Anti-viral Therapy;antiviral immunity;Applications Grants;Cell surface;Clinical;Coronavirus;Coronavirus Infections;COVID-19;cytokine;Data;Disease;Dose;Endosomes;Human;human coronavirus;human model;Immune response;Immunity;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Integration Host Factors;Interferons;knock-down;Knowledge;Lung;Lung Diseases;Macrophage;MAP Kinase Gene;MAPK1 gene;MAPK3 gene;Measures;Mediating;Mitogen-Activated Protein Kinases;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;new therapeutic target;NF-kappa B;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Pneumonia;Production;Public Health;Publishing;Pulmonary Inflammation;Pulmonary Pathology;receptor;respiratory virus;response;RNA;RNA Viruses;Role;SARS-CoV-2 infection;Severity of illness;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;small molecule;Structural Protein;success;T cell response;Testing;TNF receptor-associated factor 3;TNF receptor-associated factor 6;Toll-like receptors;TRAF6 gene;Viral;Viral Proteins;Virus;Work

PROJECT_TITLE: Myeloid cell TRAF6 signaling in SARS-CoV-2-induced dysregulated lung immunity

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Successful completion of this proposed study will help elucidate the function of DDX41 in red cell development and the pathogenesis of DDX41 mutated myelodysplastic syndromes (MDS). Understanding these processes may lead to the identification of novel targets for the treatment of MDS.

PI_NAMEs: JI, PENG  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Affect;aged;antagonist;Binding;Biogenesis;Biological Assay;Bone Marrow;CD34 gene;Cell Cycle;Cell Death;Cell Differentiation process;Cells;CFU-E;CRISPR/Cas technology;Data;Defect;Development;DNA;Dysmyelopoietic Syndromes;Embryo;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;experimental study;G-Quartets;Genes;genome integrity;genome-wide;Genomic Instability;Germ Lines;Germ-Line Mutation;Guanine;helicase;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic System;Homeostasis;Human;In Vitro;in vivo;Individual;Induction of Apoptosis;infancy;insight;Knock-out;Knockout Mice;Lead;loss of function;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloproliferative disease;novel;novel therapeutics;nucleic acid structure;Pathogenesis;Pathway interactions;Process;Proliferating;Pronormoblasts;Protein Family;replication stress;Reporting;Research;Ribosomes;Role;Small Nucleolar RNA;Somatic Mutation;Stimulator of Interferon Genes;Structure;Susceptibility Gene;targeted treatment;Testing;Therapeutic;TP53 gene;transcriptome;Up-Regulation;Variant;Zebrafish

PROJECT_TITLE: Functional roles of DDX41 in the homeostasis of G quadruplexes in erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The Alliance of Genome Resources (the Alliance) is a “knowledge commons” platform for expertly curated model organism data and annotations obtained from multiple model organism databases (MODs) and the Gene Ontology Consortium (GOC). The mission of the Alliance is to advance the utility of diverse model organisms for investigating the genetic and genomic basis of human biology, health, and disease. The primary goals for the Alliance Central outlined in this proposal are to: (1) promote comparative genomics via unified user interfaces and APIs for data types shared by the MODs and GOC, (2) promote sustainability and operational efficiencies of model organism knowledgebases by deploying and adopting shared, modular infrastructure and software, and (3) support multiple avenues for community outreach and engagement.

PI_NAMEs: BULT, CAROL J;STERNBERG, PAUL WARREN (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Adopted;Adoption;Alleles;Artificial Intelligence;artificial intelligence method;Biological;Biological Models;Biological Sciences;Biology;Biomedical Research;Caenorhabditis elegans;Communities;community engagement;Community Outreach;comparative genomics;Computer software;Data;data harmonization;data management;data modeling;data science resource;Data Scientist;data sharing;data standards;Data Store;Databases;Dedications;design;Development;Disease;disease model;Drosophila genus;Educational workshop;FAIR principles;Feedback;Funding;Gene Expression;gene function;Generations;Genes;Genetic;Genome;genome resource;Genomics;Goals;Health;Hour;Human;Human Biology;Human Genome;Human Resources;Individual;Informatics;information organization;Infrastructure;Ingestion;insight;Knowledge;knowledge commons;knowledgebase;Laboratory mice;Laboratory Rat;large language model;Leadership;Literature;Machine Learning;member;Mission;model organism;model organisms databases;Modeling;Modernization;Natural Language Processing;Nematoda;next generation;novel;Ontology;operation;Organism;Organizational Models;Pathway interactions;Pattern;Phenotype;Practice Management;Process;Proteins;Rana;Readability;Reagent;Research;Research Personnel;Resource Informatics;Resources;response;Saccharomycetales;Scientist;sharing platform;software development;Software Tools;Sustainable Development;System;Systems Development;Tail;Technology;tool;Training;Training Activity;Transgenes;United States National Institutes of Health;Variant;Xenopus;Zebrafish

PROJECT_TITLE: Alliance Central: A platform for sustainable development of next generation genome knowledgebases


ADMINISTERING_IC: OD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Estrogen;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are significant public health concerns in the United States, with growing evidence suggesting that endocrine disrupting chemicals (EDCs) may contribute to their development. However, the molecular mechanisms through which prenatal EDC exposure influences neurodevelopment remain poorly understood. The proposed research aims to examine whether the associations between prenatal EDC exposure and ASD- and ADHD-related behaviors during early childhood are mediated by biomarkers related to two potential mechanisms: inflammatory cytokines and DNA methylation.

PI_NAMEs: OH, JIWON  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: 5 year old;Address;Adverse effects;Affect;Aromatic Polycyclic Hydrocarbons;Attention deficit hyperactivity disorder;autism spectrum disorder;Award;Behavior;Behavior assessment;Benzophenones;Biological;Biological Markers;Blood;Brain;C-reactive protein;career;Chemical Exposure;chemical group;Chemicals;Child;Child Behavior Checklist;Child Health;cohort;Complex;critical period;cytokine;Cytosine;Data;Data Set;Development;Disease;DNA Methylation;early childhood;Economics;Endocrine;Endocrine Disruptors;Environment;environmental chemical;Environmental Epidemiology;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;Epigenetic Process;epigenome;Esters;Etiology;experimental study;Exposure to;Faculty;Fellowship;fetal;Flame Retardants;Genes;Genetic;Goals;Grant;Guanine;high risk;Homeostasis;Hormones;Immune;Immune system;Immunology;Individual;Inflammation;Inflammatory;Inflammatory Response;Inherited;Interferon Type II;Interleukin-6;Investigation;Knowledge;Lead;Link;Measures;Mediating;Mediation;Mediator;Mentors;Methodology;Modification;Molecular;Molecular Epidemiology;multidisciplinary;neurodevelopment;Neurodevelopmental Disorder;novel;offspring;Organophosphates;Outcome;Parabens;Pathway interactions;Phenols;phthalates;Pilot Projects;Play;Pregnancy;pregnant;prenatal;prenatal environmental exposure;prenatal exposure;Problem behavior;programs;Public Health;Research;Research Activity;Research Personnel;Risk;Role;Sample Size;Sampling;Signal Pathway;Site;social;Spottings;Technical Expertise;TNF gene;Training;Training Activity;triclocarban;Triclosan;Umbilical Cord Blood;United States;Urine;Work

PROJECT_TITLE: Prenatal Exposure to Endocrine Disrupting Chemicals and Child Neurodevelopmental Disorders: Mediation by Cytokines and DNA Methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-F (50)]


ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Cancer kills the second most people after cardiovascular diseases, and conquering cancer depends on basic and translational research that often need specialized expertise, sophisticated technologies and instrumentation unable to be mastered by individual researchers. I am a highly accomplished research specialist and a long-term technical leader who has made hundreds of genetically engineered mouse models essential for the success of many cancer research programs led by many cancer investigators. With the support of an NCI R50 grant, I will develop new mouse, rat and Nile rat genome-editing methodologies and many novel genetic rodent models for cancer research to help conquering cancer and advance my professional career at the same time.

PI_NAMEs: LIAO, LAN  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Alleles;anti-cancer research;Basic Science;Cancer Model;Cancer Research Project;Cardiovascular Diseases;career;Center Core Grants;Collaborations;Comprehensive Cancer Center;CRISPR/Cas technology;Direct Costs;Disease;Embryo;Embryo Transfer;embryonic stem cell;Ensure;Equipment;Event;experience;Fertilization in Vitro;Funding;Gene Targeting;Generations;Genetic;Genetic Engineering;Genetically Engineered Mouse;genome editing;Genome engineering;Genotype;Goals;Grant;Individual;instrumentation;International;Knock-in;Knock-out;Knowledge;Malignant Neoplasms;Manuscripts;medical specialties;meetings;member;Methodology;Methods;Microinjections;Molecular Target;Mus;new technology;novel;Persons;Physicians;Play;prime editing;Production;programs;Publishing;rat genome;Rattus;Research;Research Personnel;Research Project Grants;Rodent;rodent genome;Rodent Model;Role;Scientist;Service delivery model;Services;Specialist;sperm cryopreservation;success;System;Technology;Therapeutic;Time;Transgenes;Transgenic Organisms;Translational Research;Update;Variant;Work;zygote

PROJECT_TITLE: Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model Services

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The Eye Adult Changes in Thought (ACT) study builds on the success of the first funding cycle (>60 publications) and proposes state-of-the-art visual function and retinal imaging data collection while leveraging the parent ACT study’s growth from 2000 to 3000 active participants, with new enrollees specifically targeted to enhance diversity. The investigators expect to recruit >90% of the ACT study for Eye ACT prospective data collection with three non-invasive ophthalmic imaging modalities and analyze these data with next generation machine learning approaches to evaluate associations with cognitive decline and testing visual impairment as a causal mediator in the relationship between eye diseases and Alzheimer’s disease and related dementia (ADRD) (Aim 1). The investigators will leverage extensive neuropathology data for evaluating vascular disease as a potential mechanistic link between eye diseases, ADRD neuropathology and ADRD dementias (Aim 2), and build a novel ophthalmic data curation and sharing platform to address the critical need in the field for large and comprehensive datasets of well characterized individuals to be available for interested researchers anywhere while addressing data privacy concerns through a proof-of-concept federated learning study (Aim 3).

PI_NAMEs: LEE, CECILIA SUNGMIN (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Abbreviations;Acceleration;Address;Adult;Age related macular degeneration;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical method;Angiography;Anterior;Area;Artificial Intelligence;artificial intelligence algorithm;Attenuated;Autopsy;Bayesian Modeling;Blood Vessels;Brain;brain tissue;Cataract;causal model;Central Nervous System;Cerebrovascular Disorders;Cessation of life;Characteristics;Chronic;Clinic Visits;Clinical;Clinical Data;Cognition;Cognitive;cognitive testing;cohort;Cohort Studies;Collaborations;Collection;Consent;COVID-19;Data;Data Collection;data curation;data privacy;Data Set;data sharing;Dementia;dementia risk;design;Development;Diabetic Retinopathy;Diagnosis;Disease Outcome;Enrollment;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Eye;Eye diseases;FAIR principles;federated learning;follow-up;Funding;Fundus photography;Glaucoma;Goals;Grant;Growth;Home;Image;imaging modality;Impaired cognition;improved;in vivo;Individual;Infarction;Infrastructure;innovation;interest;International;Link;Longitudinal Studies;Machine Learning;machine learning model;Manuals;Mediating;Mediation;Mediator;Modeling;Modernization;Modification;Natural Language Processing;neuropathology;next generation;novel;older adult;Optical Coherence Tomography;Outcome;Paper;Parents;Participant;Pathology;Perfusion;Persons;primary outcome;Privacy;Productivity;programs;prospective;Protocols documentation;Publications;Publishing;Race;racial diversity;racial minority;Records;recruit;Research;Research Personnel;research study;resilience;Resources;Retina;retinal imaging;retinal nerve fiber layer;Sample Size;Sampling;Science;Security;Sensory impairment;Severities;Severity of illness;sharing platform;Socioeconomic Status;spelling;success;Testing;Thinness;Training;United States National Institutes of Health;Vascular Diseases;Vision;Visit;Visual impairment;Work

PROJECT_TITLE: Aging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) study

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: HALETHORPE

ORG_NAME: FZATA, INC.

ORG_STATE: MD

PHR: Narrative: Chronic visceral pain is a defining feature of irritable bowel syndrome, for which the current treatment options are often ineffective and associated with side effects. The goal of this project is to develop a patient- friendly, safe, non-addictive, first-in-class, oral therapeutic to treat chronic visceral pain in patients with irritable bowel syndrome and fulfill the unmet medical need.

PI_NAMEs: FENG, HANPING ;WEI, FENG ;YANG, ZHIYONG  (contact)

PROGRAM_OFFICER_NAME: HACHICHA, MOHAMED

PROJECT_TERMS: Advisory Committees;Affect;Animal Disease Models;Animal Diseases;Animal Model;Animals;Antibiotics;Biological;Biological Response Modifier Therapy;Black Box;CD34 gene;cell bank;central sensitization;Chronic;Clinical;Clinical Trials;Contracts;cost;cost effective;Cyclic GMP;Development;disorders of gut-brain interaction;Dose;drug candidate;Drug Kinetics;Engineered Probiotics;enteric pathogen;Etiology;Exhibits;Family suidae;FDA approved;Feedback;first-in-human;Friends;Gastrointestinal tract structure;Goals;gut inflammation;gut microbiota;Health Care Visit;High Prevalence;Human;humanized mouse;Hyperalgesia;Hypersensitivity;Immune System Diseases;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injections;innovation;Intestines;Irritable Bowel Syndrome;Malignant Neoplasms;manufacture;Maryland;Medical;Medical Care Costs;Morbidity - disease rate;mortality;Mus;Needles;Nerve;neuroinflammation;neutralizing antibody;Nociception;novel;Opioid;opioid epidemic;Oral;oral immunotherapy;Outcome;Pain;pain model;Pamphlets;Pathogenesis;Patients;Peripheral;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;phase 1 designs;Phase I Clinical Trials;Play;Population;pre-clinical;pre-Investigational New Drug meeting;preclinical development;Productivity;Property;Quality of life;Readiness;Reporting;Research;Research Personnel;Resolution;Resources;response;Role;Saccharomyces;Safety;side effect;Site;System;Therapeutic;therapeutic development;therapeutic target;therapeutically effective;Tissues;TNF gene;Toxicology;Treatment Efficacy;United States National Institutes of Health;Universities;Up-Regulation;Visceral;Visceral pain;Women's prevalence;Yeasts

PROJECT_TITLE: A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-E (05)]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Healthcare associated infections (HAI) are a significant source of preventable morbidity and mortality that disproportionately affect the elderly, immunocompromised, and critically ill. We plan to improve the prevention and control of HAI by advancing quantitative methods that address HAI transmission including multiscale models to quantify emergence and transmission pathways for resistant pathogens and phylodynamics methods that use sequence data to quantify the effect of resistant traits on bacteria fitness.

PI_NAMEs: LANZAS, CRISTINA  (contact)

PROJECT_TITLE: CK20-003 Modeling Infectious Diseases in Healthcare Research Projects to Im


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Urologic Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Urinary tract infections (UTIs) are a major driver for antibiotic prescriptions worldwide, with uropathogenic E. coli (UPEC) accounting for >75% of all UTIs. As a result of increasing antibiotic resistance, last resort antibiotics like fosfomycin have begun to be prescribed more frequently. In this work, I propose to determine how resistance to fosfomycin influences UPEC infection progression and to classify currently uncharacterized routes to fosfomycin resistance relevant to the clinical field.

PI_NAMEs: BERMUDEZ, TOMAS ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Accounting;Acute;Affect;American;Amino Acids;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Infections;Bacterial Proteins;Bacteriuria;Biological Assay;Bladder;Cell Culture Techniques;Cells;Chronic;Citric Acid Cycle;Classification;Clinical;Clinical Research;Cystitis;Data;Defect;Diffusion;Disadvantaged;Drug resistance;drug resistant pathogen;Effectiveness;Epithelial Cells;Escherichia coli;Escherichia coli Infections;Eukaryotic Cell;European;Exposure to;fitness;fitness test;Fosfomycin;Genomics;Gluconeogenesis;Glucose-6-Phosphate;Glycolysis;Glycolysis Pathway;Growth;Health care facility;host colonization;Immune response;Impairment;In Vitro;Infection;Infective cystitis;insight;Institution;Intoxication;Kinetics;Laboratories;Metabolic;Microscopy;Modeling;mouse model;Multi-Drug Resistance;Mus;mutant;Mutation;novel;Organism;Parents;pathogen;Pathogenesis;Patients;Peptidoglycan;Pharmaceutical Preparations;Physiology;Predisposition;Production;Resistance;response;Role;Route;Sepsis;skills;Stress;System;Techniques;Testing;urinary;Urinary tract;Urinary tract infection;Uropathogenic E. coli;Virulence;Work

PROJECT_TITLE: The roles of fosfomycin resistant subpopulations of Escherichia coli in urinary tract infection.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Mental Illness;Methamphetamine;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: HANOI

ORG_COUNTRY: VIETNAM

ORG_FIPS: VM

ORG_NAME: HANOI MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE  The high comorbidity of mental health issues and meth use in women worsens both their mental health and meth use outcomes. We propose to evaluate the potential of Friendship Bench to be used as a low-threshold, task-shifting mental health intervention among women who use methamphetamine in Vietnam – a lower- middle-income country. The study will provide preliminary data for our R01 trial testing the effectiveness Friendship Bench to improve mental health and methamphetamine use outcomes among women who use methamphetamine in Vietnam and help the candidate of this career development award acquire critical knowledge and skills to become an independent researcher.

PI_NAMEs: NGUYEN, TRANG  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Address;Africa South of the Sahara;Anxiety;arm;Award;Biological;career;Caring;Chairperson;community engagement;community organizations;comorbidity;contextual factors;coping;Country;Data;Dedications;depressive symptoms;design;Drug usage;Drug user;effective therapy;Effectiveness;effectiveness testing;Emotional;Enrollment;Ensure;Epidemiology;evidence base;Evidence based intervention;experience;Focus Groups;Friendships;future implementation;Gender;Goals;Health;Health behavior;Health care facility;Healthcare Systems;High Prevalence;HIV;Home visitation;Human Resources;Hybrids;implementation science;implementation strategy;improved;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;male;Manuals;Medical;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;methadone treatment;Methamphetamine;methamphetamine use;methamphetamine user;Modeling;North Carolina;Opioid;opioid use disorder;Outcome;Patient Self-Report;pediatric trauma;peer;peer networks;Perception;Persons;Pharmaceutical Preparations;Population;Populations at Risk;post intervention;Prevalence;problem solving therapy;professor;Protocols documentation;Province;Psychiatric therapeutic procedure;Psychiatry;Public Health;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Proposals;Resources;Route;scale up;Secure;Self-Injurious Behavior;Services;sexual violence;Shapes;skill acquisition;skills;social culture;Socialization;southeast Asian;Southeastern Asia;Stress;Subgroup;substance use;Thinking;Time;Training;trial design;Universities;Urinalysis;Vietnam;Vietnamese;Vulnerable Populations;Woman;women's outcomes;Work

PROJECT_TITLE: Friendship Bench for Women Who Use Methamphetamine in Vietnam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Adolescent obesity in the United States continues to be an epidemic, disproportionately affecting Hispanic adolescents. This study proposal will result in research findings on 1) the role of etiological factors using a socioecological perspective on Hispanic adolescent obesity, 2) the use of ecological momentary assessment to examine momentary effects of family functioning on obesity risk behaviors, and 3) preliminary evidence used to develop an ecological momentary obesity intervention protocol. The long-term outcome of this research study includes the development of an ecological momentary intervention that has the potential to reduce obesity in Hispanic adolescents.

PI_NAMEs: FERNANDEZ, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: acceptability and feasibility;Acculturation;Address;Adolescent;Adolescent obesity;Affect;Age;American Psychological Association;Area;Behavior;Behavior Therapy;Body mass index;Brain;Caregivers;Caring;Characteristics;Child;Chronic;cognitive development;cohort;Communities;Conflict (Psychology);Data;Data Analyses;Data Collection;design;Development;Ecological momentary assessment;efficacy testing;Epidemic;Etiology;Family;Family dynamics;Fathers;feeding;fruits and vegetables;Goals;grandparent;Health Sciences;Heart Diseases;High Prevalence;Hispanic;Hispanic Populations;Hour;Household;improved;Influentials;innovation;Intake;Intervention;intervention effect;Malignant Neoplasms;Measurement;Measures;member;Mentors;Mentorship;Methods;minority health;Modeling;Modification;Mothers;neighborhood safety;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;nutrition;obese person;Obesity;obesity prevention;obesity risk;obesity treatment;Outcome;Outcomes Research;Parents;Participant;peer;Physical activity;primary caregiver;Protocols documentation;Public Health Schools;Recommendation;recruit;Research;Research Personnel;research study;Review Literature;Risk Behaviors;Risk Factors;Role;Sample Size;Sampling;Schools;Sleep;tailored messaging;Texas;Time;Training;Treatment Efficacy;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Exploring longitudinal and momentary effects of family functioning on obesity risk behaviors in Hispanic adolescents and family units


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Connecting Veterans to meaningful employment is a goal of VA, which has long recognized the important relationship between work and health by providing vocational rehabilitation to Veterans with disabilities. Many Iraq and Afghanistan war Veterans have experienced polytrauma/traumatic brain injury (PT/TBI) and are unemployed and looking for work. Studies have shown that some individuals with PT/TBI have trouble finding or keeping jobs because of problems with headaches, concentration, memory, planning, and other symptoms resulting from the injury. Supported employment (SE) is an effective program that helps Veterans find work that is meaningful to them, and provides them with unlimited support and job coaching. The Veteran’s SE and treatment teams work together to develop strategies for success in the workplace. This study will provide SE services to Veterans with PT/TBI and measure their employment, health symptoms, and self-esteem over time, and how well the SE and PT/TBI teams work together.

PI_NAMEs: POGODA, TERRI K. (contact)

PROJECT_TERMS: Address;Afghanistan;care systems;Caring;Client;Clinic;Clinical;Cognitive;Collaborations;Compensation;Diagnosis;disability;Educational Materials;Effectiveness;Emotional;Employment;Ensure;Evaluation;evidence base;Evidence based practice;experience;Freedom;gaps in access;Goals;Headache;Health;Health Services;Health Services Accessibility;Healthcare;Impairment;implementation strategy;Improve Access;improved;Individual;Injury;innovation;interest;Intervention;intervention refinement;Interview;Iraq;Marketing;Measures;Medical center;Memory;Mental Health;Methods;Modeling;Multiple Trauma;Occupations;operation;Outcome;Perception;Personal Satisfaction;Physical Medicine;Physical Rehabilitation;Population;post intervention;preference;prevent;Program Evaluation;programs;Promoting Action on Research Implementation in Health Services framework;Provider;psychologic;psychosocial;Recommendation;rehabilitation service;Reporting;Research;Resources;self esteem;service member;Services;severe mental illness;Site;skills;social;Specialist;success;Supported Employment;Surveys;Symptoms;Therapeutic;Time;Traumatic Brain Injury;Unemployment;Veterans;Vocation;Vocational rehabilitation;War;Work;Workplace

PROJECT_TITLE: Improving Access to Supported Employment for Veterans with Polytrauma/Traumatic Brain Injury

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF CAMBRIDGE

ORG_ZIPCODE: CB2 1TN

PHR: PROJECT NARRATIVE (HG003345) The HUGO Gene Nomenclature Committee (HGNC) is the only organisation worldwide that provides official unique symbols and names for all human genes, and coordinates gene naming across vertebrate species. Standardized gene naming is an essential component of genomics, and hence a key feature of the infrastructure of biomedical research that must be actively maintained and updated. The HGNC's resources accelerate science by providing a common language to discuss genes; as genomic medicine becomes mainstream, the need for this common language becomes ever more vital.

PI_NAMEs: BRUFORD, ELSPETH  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TITLE: The Nomenclature of Human and Vertebrate Genes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Nanotechnology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Endothelial inflammation occurs in the setting of severe COVID-19 infection, leading to organ dysfunction and thrombosis. We have recently identified that an increase in a histone methyltransferase, MLL1/Kmt2a, is responsible for altering the adhesive and thrombotic properties of the endothelial cell by enabling gene transcription. In this proposal we will understand the mechanisms that lead to increased MLL1 activity and test new cell targeted therapies to restore endothelial homeostasis.

PI_NAMEs: OBI, ANDREA TARA (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: 2019-nCoV;Address;Adhesives;Anticoagulants;attenuation;Biological Assay;Blood Vessels;Cell Adhesion;Cell Adhesion Molecules;Cell Physiology;Cells;Characteristics;Chromatin;Clinical;Coronavirus;Coronavirus Infections;Data;Development;Disease;Edema;Encapsulated;Endothelial Cells;Endothelium;Enzymes;epigenetic regulation;experimental study;Functional disorder;Gatekeeping;Gene Expression;Genes;Genetic Transcription;Goals;Health;histone methyltransferase;histone modification;Histone-Lysine N-Methyltransferase;Homeostasis;Human;Immune response;Immunomodulators;improved;In Vitro;in vivo;Inflammation;inhibitor;innovation;Innovative Therapy;insight;interleukin-1 receptor-associated kinase;interstitial;IRAK4 gene;Laboratories;Leukocytes;Lung;Mediating;Mediation;Mediator;Methylation;migration;Mixed-Lineage Leukemia;MLL gene;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;Mus;Mutagenesis;nanoparticle;nanoparticle delivery;NF-kappa B;novel;Organ;pathogen;Pathologic;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;pharmacologic;Pneumonia;post SARS-CoV-2 infection;pre-clinical;prevent;Prevention;Promoter Regions;Property;recruit;Regulation;research facility;response;Risk;RNA Interference;Role;SARS-CoV-2 infection;Series;severe COVID-19;Severity of illness;Signal Pathway;Signal Transduction;Specimen;STAT protein;STAT1 protein;Steroids;Surface;System;targeted treatment;Techniques;Testing;Thrombosis;thrombotic;thrombotic complications;Time;tissue injury;Tissues;Vaccines;vascular endothelial dysfunction;vascular injury;Viral;Virus Diseases

PROJECT_TITLE: Kmt2a/MLL1 regulation of endothelial activation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Services;Maternal Health;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE In 2022-2023, Midwestern states enacted major policy changes with immediate implications for legal access to pregnancy-related care for millions of people. This study examines the barriers to abortion care faced by pregnant Midwesterners in the wake of these major policy shifts, and the longitudinal impact of those barriers on pregnancy and other physical, mental, and financial health outcomes. Data from this study will be used to communicate the public health impact of restrictions on abortion care, and to inform a health communication outreach intervention to improve healthcare access and reduce maternal morbidity for those in the Midwest.

PI_NAMEs: MOSESON LIDOW, HEIDI SERENE;WILKINSON, TRACEY  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;access restrictions;Address;barrier to care;Belief;Birth;Caring;Clinic;Clinical;Communication;Country;court;Data;design;Environment;evidence base;Exclusion;experience;Face;feasibility testing;Fertility;Funding;Geography;Goals;Health;health care availability;health communication;health economics;health organization;human centered design;Improve Access;improved;Intervention;Interview;Knowledge;Laws;Legal Abortion;legal implication;Link;maternal morbidity;Measures;Methodology;Midwestern United States;multilevel analysis;National Institute of Child Health and Human Development;Nature;Outcome;outreach;Participant;Pathway interactions;Patient Recruitments;permissiveness;Persons;Phase;Policies;Policy Maker;Politics;Population;Pregnancy;Pregnancy Outcome;pregnant;Prenatal care;prospective;Psyche structure;Public Health;recruit;Reproductive Health;Research;Sample Size;Sampling;Selection Bias;Self Management;Shock;socioeconomics;Spanish;Spontaneous abortion;Statutes and Laws;Strategic Planning;Surveys;Telemedicine;Testing;Time;underserved area;United States;Women's Health

PROJECT_TITLE: Time sensitive research on barriers to pregnancy care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-H (57)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE  Alcohol use among sexual and gender minorities is a significant public health concern, yet individual differences and processes of risk among these communities remain unclear. In this proposal, we aim to identify intersectional, systemic, and minority stress factors driving of alcohol risk in these communities using novel machine learning methods in longitudinal national data preceding, during, and after the coronavirus pandemic. This will identify for whom and why alcohol risk is greatest among these underserved populations, informing specialized strategies for alcohol prevention and responsive public health intervention during future global health crises.

PI_NAMEs: MCCABE, CONNOR J (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;Adolescence;Adult;Adult women;Advocacy;Age;Alcohol consumption;alcohol misuse;alcohol prevention;alcohol risk;Alcohols;All of Us Research Program;Automobile Driving;Award;Behavior;Bisexual;black women;Black, Indigenous, People of Color;career;cisgender;Communities;Complex;Consensus;coping;coronavirus pandemic;COVID-19;COVID-19 pandemic;Cross-Sectional Studies;Data;Data Set;Development;discrete data;Discrimination;Disease;Disparity;Employment;Equation;Ethnic Origin;experience;faculty research;Female;Financial Hardship;forest;Foundations;Future;Gender;gender minority;gender minority community;gender minority group;gender minority men;gender minority status;global health;Goals;Growth;hate crimes;Health;Heterogeneity;Heterosexuals;high dimensionality;high risk;Housing;Individual;Individual Differences;Inequity;Informal Social Control;intersectionality;K-Series Research Career Programs;Laws;Lesbian Gay Bisexual;Link;Machine Learning;machine learning method;marginalization;Mediating;Mediator;Mentors;Mentorship;Methodology;Methods;minority stress;minority stressor;Modeling;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;non-heterosexual;nonbinary;novel;pandemic disease;pandemic impact;pandemic stress;pandemic stressor;Participant;Pathway interactions;Persons;Phase;Policies;Population;Positioning Attribute;post-pandemic;pre-pandemic;Prevention;Process;programs;psychologic;Public Health;public health intervention;Race;racism;random forest;Recovery;Reporting;Research;Resources;Risk;Risk Factors;Role;Sampling;Scientist;sex;Sexism;Sexual and Gender Minorities;sexual minority;sexual minority group;social;Social status;Social support;Stigmatization;Stress;stressor;Subgroup;substance use;Surveys;Symptoms;Testing;theories;Training;transgender;transgender women;Underserved Population;United States National Institutes of Health;White Women;Woman;women of color;Work;young adult;young woman

PROJECT_TITLE: Machine learning methods for identifying person-level mechanisms of alcohol use among sexual and gender minority intersections

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHYSIOLOGY

PHR: . There are no changes to the original Project Narrative. The adrenal cortex is composed of three zones that include: an outer adrenal zona glomerulosa that produces mineralocorticoids, a middle zona fasciculata that produces glucocorticoids and the inner zona reticularis that produces androgens and androgen precursors. This zonation of the adrenal is established by centripetal ‘streaming’ of the outer subcapsular progenitor cells to the inner zones; and its functionality is maintained by the differential expression of the enzymes required for mineralocorticoid vs. glucocorticoid vs. androgen production. The proposed research will define (1) the factors causing progenitor cell differentiation into steroid-producing glomerulosa cells; and (2) the mechanisms leading to innermost reticularis cell androgen production.

PI_NAMEs: RAINEY, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 7 year old;Adrenal Cortex;Adrenal Cortex Hormones;Adrenal Glands;Adrenal hormone preparation;Aldosterone;Anabolism;Androgens;Angiotensin II;antagonist;Apoptosis;ATAC-seq;Binding Sites;Biology;Blood;Cell Differentiation process;Cells;Cholecalciferol;Chromatin;Complex;CYP11B2 gene;Data;daughter cell;dehydroepiandrosterone;Dehydroepiandrosterone Sulfate;Developmental Biology;Dietary Sodium;differential expression;Disease;Endocrine;Enzymes;ERR1 protein;Gene Expression;Genetic Transcription;Glucocorticoids;Growth;Homeostasis;Hormones;Human;Human Biology;Hydrocortisone;Hydroxysteroid Dehydrogenases;improved;In Situ;In Vitro;in vivo;Infant;Label;Life;Ligands;Maintenance;mass spectrometric imaging;Mediating;Mineralocorticoids;Molecular;mouse model;multiple omics;Mus;Nuclear Hormone Receptors;Nuclear Receptors;paracrine;Phenotype;Population;postnatal;PPAR gamma;Process;Production;progenitor;Proliferating;Research;Resolution;Role;Scheme;SF1;SHH gene;Signal Pathway;Signal Transduction;stem cell differentiation;stem cell homeostasis;stem cells;stemness;steroid sulfotransferase;Steroids;Stream;Techniques;Testing;Tissues;transcription factor;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;transcriptomics;transdifferentiation;Transgenic Mice;Undifferentiated;Vitamin D3 Receptor;WNT Signaling Pathway;Zona Fasciculata;Zona Glomerulosa;Zona Reticularis

PROJECT_TITLE: Mechanisms Leading to Adrenal Zonation

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: LANSING

ORG_NAME: NOVASTERILIS, INC.

ORG_STATE: NY

PHR: NARRATIVE NovaSterilis, Inc. intends to develop and commercialize its novel sterilization platform based on supercritical carbon dioxide (scCO2) and powerful sterilant, NovaKill™ for the pharmaceutical market – NovaAPI™. Sterilization of drug substances (or active pharmaceutical ingredients; APIs) and drug products is a challenging application due to the complexities of many drugs and biologics and the minimal compatibility of current sterilization modalities (e.g., steam, radiation, ethylene oxide). This effort will draw form previous research results that support the development of the NovaSterilis platform for sterilization of drug substances and products with the potential for developing a terminal sterilization process for final drug products in vial/syringe format.

PI_NAMEs: STRICKLAND, AARON D (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;base;Biological Products;Carbon Dioxide;cold temperature;commercialization;Computer software;Consumption;cost;Development;Drug Industry;drug market;Drug usage;Educational Personnel;Equipment;Ethylene Oxide;Freeze Drying;Guidelines;Industry;innovation;insight;manufacture;Manufacturer;Marketing;Medical Device;Methods;Modality;novel;Penetration;Pharmaceutical Preparations;Pharmaceutical Technology;Pharmacologic Substance;Phase;Process;programs;Radiation;Research;Residual state;Resources;Risk;Sales;scale up;seal;Services;Steam;Sterility;Sterilization;Syringes;Techniques;Technology;Testing;Therapeutic;Time;Training and Education;United States National Institutes of Health;Validation;Vial device;Work

PROJECT_TITLE: NovaAPI: Terminal Sterilization of Drug Substances and Products


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative In this study will use two national data sources and primary data collection to estimate inequities in, and elicit lived experiences of, financial hardship among LGBTQ+ cancer survivors and caregivers. By understanding financial hardship heterogeneity and modifiable factors, this study goes far beyond simply documenting LGBTQ+ differences and tangibly moves towards equity in health care quality, affordability, and access for LGBTQ+ cancer survivors and caregivers. The findings from this study will inform multi-level interventions and policy that are specific to the LGBTQ+ population—an understudied population at risk of poor economic outcomes.

PI_NAMEs: WATERS, AUSTIN RICHARD (contact)

PROGRAM_OFFICER_NAME: GAINES, CHRISTOPHER M

PROJECT_TITLE: Financial Hardship among LGBTQ+ Cancer Survivors and Caregivers: Prevalence, Determinants, and Access to Care

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: There are no approved treatments for congenital cognitive impairments in individuals with Autism Spectrum Disorder (ASD). However, our preliminary results indicate that limited postnatal treatment with the hypothalamic peptide oxytocin can effect a life-long rescue of memory functions in the mouse model of Fragile- X Syndrome, the leading inherited cause of ASD. The proposed studies will test if postnatal oxytocin treatment rescues a range of social and episodic memory functions, and normalizes neurobiological processes underlying memory encoding in the Fragile X model mutants, and if these functional changes reflect direct oxytocin action on trophic signaling in the developing hippocampus.

PI_NAMEs: GALL, CHRISTINE M (contact);LYNCH, GARY S

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acute;Address;Adult;Affect;Agonist;Animal Model;ASD patient;autism spectrum disorder;Behavior;Behavioral;Brain;Brain region;Brain-Derived Neurotrophic Factor;cellular targeting;Child;Childhood;Cognitive;cognitive function;comorbidity;critical developmental period;critical period;design;Development;developmental disease;Disease;DTR gene;early phase clinical trial;Electrophysiology (science);Elements;Epidermal Growth Factor Receptor;Episodic memory;Excitatory Synapse;Exhibits;Female;Fragile X Syndrome;Future;Genetic Techniques;Goals;Hippocampus;Hypothalamic structure;Impaired cognition;improved;individuals with autism spectrum disorder;Inherited;Inhibitory Synapse;Intellectual functioning disability;interest;Knowledge;Learning;Life;Location;Long-Term Potentiation;male;Measures;Mediating;Memory;memory encoding;Memory impairment;model of autism spectrum disorder;Modeling;Morphology;mouse model;Mus;mutant;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropeptides;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Odors;Oxytocin;Oxytocin Receptor;Peptides;personal narratives;Phenotype;Physiological;postnatal;postnatal period;Process;Property;Proteins;Receptor Protein-Tyrosine Kinases;Regimen;Regulation;response;restoration;Rodent Model;Role;Route;sex;Signal Transduction;social;Social Behavior;Social Interaction;Stereotyped Behavior;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;System;Techniques;Testing;Therapeutic;therapeutic candidate;therapeutically effective;Thinking;Trophic Factor Receptor;Vertebral column;Wild Type Mouse;Work

PROJECT_TITLE: Postnatal Oxytocin Treatment and Cognitive Function in Fragile X

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences;Nutrition

PHR: Project Narrative Sensory perception modulates many aspects of physiology and health, and our previous work in the fruit fly, Drosophila melanogaster, has established that aging is also strongly modulated by sensory systems through mechanisms that are largely unknown. Our studies will use genetic analysis to investigate central control of aging and physiology in Drosophila to illuminate how similar processes may control healthy aging in mammals.

PI_NAMEs: PLETCHER, SCOTT  (contact)

PROJECT_TERMS: adverse outcome;Affect;Afferent Neurons;Aging;aging mechanism;aging related;Air;analog;Animals;Awareness;Behavior Therapy;Behavioral;Behavioral Assay;Biogenic Amines;Biological;Biological Models;Brain;brain control;Brain region;Central Nervous System;Characteristics;Complex;Data;design;dietary restriction;Discipline;Dopamine;Drosophila genus;Drosophila melanogaster;Elements;environmental intervention;epigenome;Exhibits;experience;fascinate;Fire - disasters;flexibility;fly;Food;Funding;genetic analysis;Goals;Health;healthy aging;Homeostasis;HTR2A gene;Human;Hunger;Individual;Intervention;Knowledge;Laboratories;life span;Light;Link;Long-Term Effects;Mammals;Maps;Measures;Modeling;Modification;Mus;Nematoda;neural;neural circuit;Neurobiology;Neuromodulator;neuronal excitability;Neurons;Neuropeptides;neuroregulation;neurotransmission;new technology;Norepinephrine;novel;Nutrient;Octopamine;Organism;Output;Pain;Pathway interactions;Perception;Peripheral;Persons;Physiology;Planet Earth;Positioning Attribute;Process;Publishing;rate of aging;recruit;Research;response;Role;Scientist;Sensory;sensory input;sensory stimulus;sensory system;Serotonin;serotonin receptor;sex;Signal Pathway;Signaling Molecule;Smell Perception;sound;Structure;Synapses;System;Testing;Time;Tissues;Touch sensation;unpublished works;Vision;Visual Perception;Water;Work

PROJECT_TITLE: Modulation of aging by Sensory Perception

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]