NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HEMME, CHRISTOPHER LEE (contact)

PROJECT_TERMS: 3-Dimensional;analysis pipeline;Area;Artificial Intelligence;Big Data;Bioinformatics;Biological Sciences;biomedical data science;Biomedical Research;Biotechnology;career development;Cells;cloud based;Cloud Computing;Collaborations;college;Communities;community college;Complex;Computer software;Consultations;Core Facility;Data;data management;Data Science;Data Science Core;data science infrastructure;data science resource;Drug Design;Economic Development;Economics;Education;Education and Outreach;Educational Curriculum;Emerging Technologies;Ensure;experience;Fostering;Funding;Future;Generations;Genomics;Goals;Growth;Hybrids;Image;improved;Industry;Informatics;Institution;institutional capacity;investigator training;Joints;Machine Learning;metabolomics;Methodology;Methods;Modeling;Molecular;molecular modeling;Molecular Structure;multiple omics;Names;next generation sequencing;Ointments;Pharmaceutical Chemistry;Pharmacologic Substance;Pharmacology;programs;Proteomics;Regulation;Research;Research Personnel;Research Support;Resource Sharing;Resources;Rhode Island;Role;Science;Services;student training;Students;Technology;tool;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities;virtual;virtual classroom;Visualization;Wales;Workforce Development

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: KINGSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PI_NAMEs: CAI, ANG  (contact)

PROJECT_TERMS: analysis pipeline;base;Biomedical Research;biomedical resource;biophysical tools;Biophysics;Biotechnology;career;Collaborations;college;Communication;community college;Computer software;Core Facility;cost;Credentialing;Data;Data Analyses;Data Science;Development;DNA Sequencing Facility;Ecosystem;Educational workshop;Ensure;Equipment;experience;Fostering;Funding;Future;Generations;Goals;Grant;Growth;improved;Individual;industry partner;Informatics;Information Management;innovation;Institution;institutional capacity;instrument;instrumentation;investigator training;Laboratories;Location;Marketing;member;Molecular;Occupations;Ointments;outreach;Outsourcing;Preparation;programs;prospective;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rhode Island;Schedule;Services;skills;student training;Students;Training;Training Programs;undergraduate student;Universities;Wales;Workforce Development

PROJECT_TITLE: Centralized Research Core Facility

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PI_NAMEs: CHO, BONGSUP P (contact)

PROJECT_TERMS: Active Learning;animal facility;Area;Behavioral;Biological Models;Biomedical Research;Collaborations;cost;Data;design;Education;education research;Educational process of instructing;experience;experimental study;Faculty;flexibility;Floor;Funding;Goals;Grant;House mice;Housing;improved;Infrastructure;Institution;institutional capacity;Investments;Laboratories;Laboratory Animals;learning engagement;Mission;Mus;neurobehavioral;Neurosciences;Noise;programs;Rattus;Research;Research Infrastructure;Research Personnel;Rhode Island;Rodent;Rodent Model;Site;student training;Students;tenure track;tool;Training;Travel;undergraduate student;Universities;Work

PROJECT_TITLE: Repurposing Space for the Behavioral Neuroscience Laboratory and Vivarium Facility at Roger Williams University


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BELLINGHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: WESTERN WASHINGTON UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative. The proposed research is relevant to public health because it defines the selectivity and activity determinants of bacterial sortases, a therapeutic target for antibiotic development against Gram-positive bacteria (e.g., Staphylococcus aureus) and a widely utilized tool in protein engineering. Within these applications, the majority of sortase-mediated ligation efforts utilize a single, highly specific sortase enzyme (from S. aureus), whereas observations for the broader protein family suggest a spectrum of target specificity. A greater understanding of the mechanistic basis of bacterial sortase selectivity and activity can dramatically expand next-generation protein engineering efforts; therefore, the proposed research is directly in line with the mission of the National Institute of General Medical Sciences to “support basic research that… lays the foundation for advances in disease treatment.”

PI_NAMEs: AMACHER, JEANINE FAYE (contact);ANTOS, JOHN M;MCCARTY, JAMES JOSEPH

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 2019-nCoV;abeta accumulation;Affect;Affinity;Africa South of the Sahara;Amines;antibiotic design;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;arm;Bacillus anthracis;Bacteria;Basic Science;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Biotin;C-terminal;Catalysis;Cell surface;Cell Wall;Cessation of life;Characteristics;Chemicals;Chimera organism;Computational Biology;COVID-19 vaccine;Cysteine;Development;Diagnostic tests;Dimerization;Disease;Drug resistance;Engineering;Enzymes;Event;flexibility;Fluorescence Resonance Energy Transfer;Foundations;Gram-Positive Bacteria;Hand;Health;high throughput screening;Human;improved;In Vitro;innovation;Knowledge;Length;Ligation;Lipids;Listeria;Listeria monocytogenes;Maps;Measures;Mediating;methicillin resistant Staphylococcus aureus;Methodology;Methods;Mission;Modeling;Molecular;Molecular Conformation;molecular dynamics;Mutation;nanobodies;nanodisk;National Institute of General Medical Sciences;Nerve Degeneration;next generation;pathogen;pathogenic bacteria;Peptide Synthesis;Peptides;Peptidoglycan;Peptidyltransferase;Phase;Play;Positioning Attribute;preference;Productivity;Protein Biochemistry;Protein Dynamics;Protein Engineering;Protein Family;protein purification;Proteins;Public Health;Reaction;reaction rate;Reporting;Research;Resistant Streptococcus pneumoniae;Role;Series;sortase;Specificity;Staphylococcus aureus;Streptavidin;Streptococcus;Streptococcus pyogenes;structural biology;Substrate Interaction;System;Techniques;Testing;therapeutic target;tool;transacylation;Transmembrane Domain;vaccine evaluation;Variant;Work

PROJECT_TITLE: Improved Understanding of Bacterial Sortase Activity Towards Next-Generation Protein Engineering

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Elder mistreatment (EM) is a major public health concern, with a limited evidence-base for behavioral interventions to reduce and prevent EM and its consequences. This Roybal Center will provide an infrastructure for accelerated development of rigorous mechanistically-driven behavioral interventions for real real-world settings by addressing known barriers to EM research at the pilot stage.

PI_NAMEs: CANNELL, MICHAEL BRADLEY;PICKERING, CAROLYN E ZIMINSKI (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;Address;Adult;Advisory Committees;Aggressive behavior;Alzheimer's disease related dementia;Area;Behavior Therapy;behavioral and social science;career;Caregiver well-being;Caregivers;caregiving;Caring;Clinical Practice Guideline;cohort;Communities;Data;Dementia;design;Development;Elder Abuse;elder neglect;emotional abuse;Ensure;Evaluation;evidence base;evidence based guidelines;Evidence based treatment;experience;Exposure to;Family Caregiver;Family Relationship;financial exploitation;Fostering;Funding;Goals;Health;heart rate variability;Home;Hospitalization;Hospitals;Human Resources;human subject;implementation science;improved;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Medical center;Mental Depression;Mental Health;Mentors;Methodology;Methods;Modeling;mortality;neglect;Neurodegenerative Disorders;novel;older adult;Online Systems;Outcome;Outcomes Research;Participant;participant safety;Personal Satisfaction;physical abuse;physical conditioning;Pilot Projects;Prevalence;prevent;Prevention;programs;Public Health;Public Policy;Qualifying;Recommendation;recruit;Reporting;Research;research and development;Research Personnel;resilience;Resources;Science;screening;self neglect;service delivery;Services;Sexual abuse;social interventions;Social isolation;social science research;stem;Stress;Stroke;Texas;therapy design;therapy development;Training;Translations;Trauma;Treatment outcome;United States National Institutes of Health;United States Preventative Services Task Force;Veterans;virtual

PROJECT_TITLE: Roybal Center for Elder Mistreatment Intervention Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J3)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Dissemination and Implementation Research;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: PICKERING, CAROLYN E ZIMINSKI (contact)

PROJECT_TERMS: Acceleration;Accountability;Advisory Committees;Area;Behavior Therapy;Caregiver well-being;Clinical Practice Guideline;Collaborations;community collaboration;Complex;Decision Making;Elder Abuse;Enrollment;Ensure;evidence base;Evidence based intervention;Evidence based practice;financial exploitation;Fostering;Funding;Goals;Government;Growth;health equity;human subject;implementation science;Inequity;Information Dissemination;Infrastructure;Institutional Review Boards;Intervention;Intervention Studies;Leadership;Logic;Modeling;Monitor;Nature;neglect;novel;older adult;Outcome;Performance;Pilot Projects;Program Evaluation;Program Sustainability;Public Policy;Recommendation;repository;Research;Research Personnel;Resolution;Resources;Risk;Risk Factors;Role;Senior Scientist;service delivery;Services;Site;social health determinants;Strategic vision;United States National Academy of Sciences;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: ACIERNO, RONALD E. (contact)

PROJECT_TERMS: Address;Adult;Aggressive behavior;Alzheimer's disease related dementia;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;Caregivers;Caring;Data;Dementia;design;Elder Abuse;elder neglect;Elderly;Ensure;evidence base;Evidence based treatment;Future;Goals;heart rate variability;Home;Hospitalization;Hospitals;Individual;Intervention;Intervention Studies;maltreatment;Measures;member;Mental Depression;Mentorship;Methods;Modeling;Online Systems;Outcome;Pilot Projects;Positioning Attribute;prevent;Prevention;Process;programs;recruit;Research;Research Personnel;Risk Factors;Risk Reduction;self neglect;Services;Stress;stress reactivity;Stroke;therapy development;Training;Translations;United States National Academy of Sciences;United States National Institutes of Health;Veterans

PROJECT_TITLE: Behavioral Intervention Development Core


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Southeast Center for Agricultural Health and Injury Prevention Project Narrative In collaboration with regional stakeholders and our multidisciplinary team of investigators, the Southeast Center for Agricultural Health and Injury Prevention (SCAHIP) has developed a comprehensive plan which includes surveillance, measurement and assessment, training, intervention, and translational research projects that target important continuing problems in the agricultural and forestry sectors in the Southeastern US. The SCAHIP has invited a great number of collaborators to work together to produce measureable improvements towards safer and healther agriculture and forstry work practices and outcomes.

PI_NAMEs: SANDERSON, WAYNE T. (contact)


FUNDING_MECHANISM: OTHERS

ORG_CITY: MADISON

ORG_NAME: WISCONSIN DEPARTMENT OF HEALTH SERVICES

ORG_STATE: WI

PHR: State Occupational Safety and Health Surveillance Program (U60) PAR-20-312 Wisconsin Occupational Health Surveillance Expanded Program Project Narrative This surveillance program will increase information on occupational injuries, deaths, and exposures. Information will be used to identify surveillance trends, emerging issues, and high- risk occupations, industries and worker populations to inform development and dissemination of public health recommendations for workplace interventions.

PI_NAMEs: MCCOY, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Wisconsin Expanded Program Occupational Health Surveillance Project


ORG_CITY: ST. PAUL

ORG_NAME: MINNESOTA STATE DEPT OF HEALTH

ORG_STATE: MN

PHR: Project Narrative This project will enhance the capacity of the Minnesota Department of Health to promote occupational health and safety through surveillance of a core set of occupational health indicators and dissemination of the findings to appropriate stakeholders for use in setting priorities for education and prevention activities. The project will expand the use of industry and occupation information in established data collection efforts and will explore new sources of data in order to include previously underserved worker populations in surveillance of occupational health and safety.

PI_NAMEs: ZABEL, ERIK  (contact)

PROJECT_TITLE: Minnesota Occupational Health and Safety Surveillance Program


ORG_CITY: LINCOLN

ORG_NAME: NEBRASKA ST DEPT OF HEALTH & HUMAN SERVS

ORG_STATE: NE

PHR: Project Narrative Workers in Nebraska face risks to their health, safety, and well-being at their workplaces. State- based surveillance systems for occupational injuries and illnesses can provide critical data to assess the burden and trends of occupational morbidity and mortality in order to inform prevention efforts. The overall goal of the Nebraska Occupational Safety and Health Surveillance Program is to enhance public health surveillance in order to reduce the incidence of work-related injuries, illnesses, and exposures.

PI_NAMEs: STOVER, DERRY TODD (contact)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: NEWMAN, LEE S (contact)

PROJECT_TITLE: Mountain and Plains Education and Research Center (MAP ERC)


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lung Cancer;Prevention;Recovery Support Services;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Over 50% of smokers attempting to quit will relapse to smoking within the first year. Personal social networks can have powerful influences on smoking behavior and the chances of relapsing. The proposed study will test Helpers Stay Quit, an innovative relapse prevention program that teaches newly-quit smokers how to reach out and help others in their personal network to quit, thereby creating a social environment more supportive of staying quit.

PI_NAMEs: MURAMOTO, MYRA L. (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Abstinence;Active Listening;Address;Adult;Arizona;Behavior;behavior change;Behavior Therapy;Behavioral;Biochemical;brief intervention;Cancer Etiology;Cessation of life;Characteristics;Cigarette;cigarette smoke;cigarette smoking;Client;Communication;Complex;Counseling;design;Educational Intervention;Educational process of instructing;Effectiveness;effectiveness evaluation;evidence base;Exposure to;Feasibility Studies;Feedback;follow-up;Gender;Genitalia;Hematologic Neoplasms;Individual;innovation;Intervention;Intervention Studies;long term abstinence;Malignant Neoplasms;Mediating;member;Methodology;Methods;Modeling;Motivation;multi-component intervention;novel strategies;Outcome;Outcome Study;Pamphlets;Participant;Patient Self-Report;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Pilot Projects;Prevalence;Prevention program;Prevention Research;preventive intervention;primary outcome;Process;programs;quitline;Randomized;Randomized, Controlled Trials;Relapse;relapse prevention;Reporting;Research;Research Design;Sampling;secondary outcome;Shapes;skills;Smoke;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking cue;smoking relapse;smoking relapse prevention;Smoking Status;Social Environment;Social Network;Source;Structure;System;systematic review;Testing;theories;Time;Tobacco use;Tobacco Use Cessation;tobacco user;tobacco-free;Training;transmission process;treatment as usual;United States;Urinary system

PROJECT_TITLE: Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Depression;Dietary Supplements;Disability Research;Hypertension;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Program Director/Principal Investigator (Last, First, Middle): Morris, Martha Clare and Aggarwal, Neelum Stroke survivors are debilitated by cognitive decline, depression and disability, and pharmacologic treatments are largely ineffective. This application proposes to conduct a Phase III randomized controlled trial designed to test the effects of a 3-year intervention of the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) on cognitive decline, brain neurodegeneration, functional disability, and depression among 500 ischemic stroke patients, aged 60-80 years and without dementia who are discharged home. The project has great potential to contribute to the NIH mission of funding research that enhances health and reduces illness or disability. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: AGGARWAL, NEELUM T. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Activities of Daily Living;Acute;Advocate;Affect;aged;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Amyloid deposition;Animals;Berry;Biochemical Markers;Biological;Biological Markers;Blood;blood-brain barrier function;Brain;brain health;brain magnetic resonance imaging;brain volume;Brain-Derived Neurotrophic Factor;cardiovascular risk factor;Caring;Cerebral Infarction;Cerebrovascular system;Characteristics;Chicago;clinical research site;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;cohort;Collaborations;Consumption;cost estimate;Counseling;DASH diet;delivered meals;Dementia;depressive symptoms;design;Diet;Diet Modification;dietary;Dietary Component;Dietary Intervention;Digital biomarker;disability;Disability treatment;Disease Progression;Episodic memory;executive function;experience;Family;Food;functional disability;functional status;Funding;Health;high risk population;Hippocampus;Home;Hospitalization;Human;Hybrids;Impaired cognition;improved;Incidence;Individual;Inflammation;inflammatory marker;Intervention;Ischemia;Ischemic Stroke;Life Style Modification;Long term disability;Magnetic Resonance Imaging;Measures;Mediation;Mediator;Medical center;Mediterranean Diet;Memory;Mental Depression;Microvascular Dysfunction;Mission;Modification;Nerve Degeneration;neuron loss;neuropathology;Nutrient;nutrition;older adult;overtreatment;Oxidative Stress;Participant;Patient Recruitments;Patient Self-Report;Patients;Pattern;Persons;Pharmacological Treatment;Pharmacotherapy;Phase;Plants;Plasma;post stroke;post stroke cognitive impairment;post stroke dementia;preservation;Prevention;Prevention trial;Primary Prevention;Principal Investigator;programs;Public Health;Random Allocation;Randomized, Controlled Trials;Recommendation;recruit;Research;retinal imaging;saturated fat;Semantic memory;Senile Plaques;Short-Term Memory;Site;Specific qualifier value;Speed;Stroke;stroke patient;stroke survivor;Survivors;symptom treatment;Symptoms;Testing;Therapeutic Intervention;therapeutically effective;Time;treatment as usual;treatment duration;treatment group;trial design;United States National Institutes of Health;Universities;Vascular Diseases;Vegetables;White Matter Hyperintensity

PROJECT_TITLE: MIND DIET AND DEMENTIA PREVENTION IN ISCHEMIC STROKE PATIENTS

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: In 2016, 64,000 Americans died from accidental overdose of opioid drugs. The majority became addicted after being prescribed opioids for pain. The crisis is especially acute for veterans. Up to 25% of patients at VA outpatient clinics have received opioids for pain, and an estimated 8-12% have gone on to develop opioid use disorder. These statistics highlight a crisis that was created by a perfect storm of ill-advised pain treatment practices, healthcare expectations, and rampant availability of cheap high potency illicit opioids. To address the crisis, improved healthcare practices, better pain medications, and better addiction therapies are needed. Improved knowledge of the mechanisms underlying opioid addiction, craving, and relapse could help predict who may be at risk, and guide new therapeutic strategies for addiction that do not rely on alternative opioid medications. This proposal highlights a pathway that may contribute to addiction vulnerability, and could lead to new therapies that repurpose non-opioid medications already available for human use.

PI_NAMEs: WEMMIE, JOHN A (contact)

PROJECT_TERMS: Accidents;Acids;Acute;addiction;Address;Affect;Ambulatory Care Facilities;American;AMPA Receptors;Analgesics;ASIC channel;Behavior;Behavioral;Behavioral Paradigm;Brain;Buffers;carbonate dehydratase;Carbonic Anhydrase IV;Cations;Chronic;Cocaine;cocaine self-administration;conditioned place preference;craving;Data;Dendritic Spines;density;drug of abuse;Enzymes;expectation;experimental study;extracellular;Functional disorder;Glutamate Receptor;Glutamates;Goals;Healthcare;Human;illicit opioid;improved;inhibitor;innovation;Knowledge;Measures;Mediating;Molecular;Molecular Target;Morphine;Morphology;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;Neurobiology;Neurons;Neurotransmitters;non-opioid analgesic;novel;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use disorder;overdose death;overexpression;Pain;Pain management;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Physiology;Pilot Projects;Play;postsynaptic;prescription opioid;presynaptic;prevent;Protons;Rattus;receptor function;Regulatory Pathway;reinforced behavior;Relapse;response;Risk;Role;Self Administration;Signal Transduction;statistics;Structure;Synapses;Synaptic Cleft;Synaptic plasticity;Synaptic Transmission;Testing;United States;Vesicle;Veterans;Wild Type Mouse;Withdrawal

PROJECT_TITLE: Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Despite scientific advances in HIV prevention and care, indicators of progress toward ending HIV among people who use drugs have been moving in the wrong direction in New York, the US, and abroad. The Center for Drug Use and HIV Research provides a collaborative, transdisciplinary intellectual environment that supports our affiliated investigators to develop and carry out rigorous, high-impact research to reduce new HIV infections and improve the health and well-being of people who use drugs.

PI_NAMEs: DES JARLAIS, DON C (contact);HAGAN, HOLLY

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Acceleration;Address;AIDS prevention;base;Behavioral;Biomedical Research;Caring;Cities;Collaborations;Communities;community engagement;Community Health;Continuity of Patient Care;County;COVID-19;COVID-19 pandemic effects;Death Rate;Diagnosis;Discipline;Disease Outbreaks;Disease Outcome;disorder prevention;Disparity;Drug Industry;drug market;Drug usage;Drug user;Ensure;Environment;Epidemic;Epidemiology;Event;experience;Funding;Future;Generations;Goals;Harm Reduction;Health;Hepatitis C virus;Heroin Users;Heterosexuals;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/HCV;Homelessness;Hurricane;improved;Incidence;Income;Indiana;Individual;Inequality;Infectious Disease Epidemiology;Infrastructure;Injecting drug user;innovation;International;Interruption;Knowledge;Leadership;member;Mentors;method development;Methodology;Methods;Morbidity - disease rate;mortality;new pandemic;New York;New York City;opioid epidemic;Overdose;overdose prevention;pandemic disease;Pattern;people of color;Personal Satisfaction;Phase;Pilot Projects;Policy Maker;Poverty;pre-exposure prophylaxis;Predisposition;Prevalence;Prevention;Process;Productivity;Public Health;Recording of previous events;Research;Research Methodology;Research Personnel;Research Support;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;Scientist;Sentinel;service providers;Services;sexual minority men;Signal Transduction;skills;social;Stress;substance use;Substance Use Disorder;substance user;synergism;Syringes;Testing;theories;transgender women;transmission process;Trauma;treatment as prevention;trend;Underrepresented Populations;Unemployment;United States National Institutes of Health;uptake;Viral;Weather

PROJECT_TITLE: Reinvigorating HIV Prevention and Care for People Who Use Drugs: Accelerating Progress and Sustaining Gains in the Midst of Societal Disruption


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: 8. Project Narrative This program trains physicians, pharmacists, and scientists in the principles and practice of Clinical Pharmacology, a branch of science that focuses on the study of drugs in humans and brings basic lab discoveries into clinical practice. In a three to four-year program, trainees have rigorous in-class education and will conduct clinical studies of drugs in humans.

PI_NAMEs: IPPOLITO, MATTHEW MICHAEL (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Clinical Pharmacology;Training Programs

PROJECT_TITLE: Clinical Pharmacology Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: HAGAN, HOLLY  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Advocate;AIDS prevention;base;Behavioral;Caring;Collaborations;Communities;community collaboration;Community Health;community partners;COVID-19;Creativeness;Databases;design;Development;dissemination strategy;Drug usage;Drug user;Ensure;Environment;Evaluation;Event;experience;Fostering;Goals;Harm Reduction;health disparity;health inequalities;HIV;improved;Individual;Infectious Disease Epidemiology;innovation;Institutional Review Boards;interdisciplinary collaboration;Intervention;Knowledge;Leadership;Learning;Life;meetings;member;Mentors;multidisciplinary;NIH Office of AIDS Research;novel;Persons;Pilot Projects;Policy Maker;Productivity;Public Health;Regulation;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;response;Risk;Role;Scholars Program;Scientist;service providers;Shapes;skills;social;Source;Structure;substance use;Suggestion;Surveys;synergism;Testing;theories;Thinking;Training;trend;Trust;Underserved Population;United States National Institutes of Health;Update;visiting scholar;Vulnerable Populations;Work


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative A critical challenge for all cardiovascular regenerative strategies is the need for neovascularization to support any newly generated cardiomyocytes. This project seeks to identify the role of O-GlcNAcylation in transdifferentiation and epigenetic plasticity, which will identify an epigenetic mechanism for cellular plasticity and a novel therapeutic target to enhance endogenous neovascularization for treatment of cardiovascular disease. The goals of these studies will uncover novel mechanisms of metabolic regulation of cell fate plasticity, which will lead to interventions for the treatment of ischemic syndromes, a goal consistent with the mission of the National Heart, Lung, and Blood Institute: to “understand normal biological function and resilience” in order to “develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases.”

PI_NAMEs: LU, ALEXANDER J. (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acetyl Coenzyme A;Affect;Attenuated;Biological Process;Blood Vessels;candidate identification;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;Cell Fate Control;Cell Line;Cells;Coin;Data;Disease;DNA;Endothelial Cells;Enzymes;Epigenetic Process;established cell line;experimental study;Fibroblasts;fluidity;Gene Expression;Genetic;Global Change;Goals;Heart failure;Hindlimb;Histone Acetylation;Immune signaling;improved;In Vitro;in vivo;Inflammatory;Intervention;Ischemia;ischemic injury;Knockout Mice;Laboratories;limb ischemia;Link;Medicine;Metabolic;Metabolic Control;Metabolism;Mission;Modeling;multiple omics;Mus;Myocardial Infarction;National Heart, Lung, and Blood Institute;neovascularization;new therapeutic target;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Nuclear;Nutrient;Pathway interactions;Perfusion;pharmacologic;Phenotype;Population;Post-Translational Protein Processing;prevent;Primary Cell Cultures;Process;Proteomics;Recovery;regenerative;regenerative approach;Regenerative Medicine;Reporter;Research Training;resilience;Role;Signal Pathway;Site;Syndrome;Testing;therapeutic angiogenesis;Tissues;transdifferentiation;Treatment Efficacy;Uridine Diphosphate N-Acetylglucosamine;vasculogenesis

PROJECT_TITLE: Metabolic Control of Epigenetic Reprogramming in Neovascularization


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;AIDS prevention;Automobile Driving;Behavioral;Behavioral Research;biobehavior;Biological;Caring;Characteristics;Cities;climate change;climate disaster;Clinical;clinical care;co-infection;Collaborations;Communities;comorbidity;Consultations;COVID-19 pandemic;Creativeness;Development;Disease Outbreaks;Disease Outcome;Disparity;drug market;Drug usage;Drug user;Economics;effective intervention;Environment;Epidemic;Epidemiology;epidemiology study;ethnic disparity;Event;Evolution;Failure;falls;Floods;Future;Generations;Goals;Harm Reduction;Health system;Hepatitis C;HIV;HIV diagnosis;HIV Infections;housing instability;Humanities;Hurricane;Imprisonment;Incidence;Individual;Inequality;Inequity;Infection;Infectious Disease Epidemiology;injection drug use;Injections;innovation;Intervention;Intervention Studies;Knowledge;knowledge integration;Lead;Leadership;Liver diseases;Medical;member;Morbidity - disease rate;mortality;Natural History;New York;novel;opioid epidemic;Outcome;pandemic disease;Persons;Pharmaceutical Preparations;Police;Policies;Population;Poverty;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Process;Productivity;Prognosis;Public Health;public health intervention;Public Policy;racial discrimination;racial disparity;racism;Research;Research Personnel;resilience;severe weather;Sexually Transmitted Diseases;Shapes;Signal Transduction;social;social factors;social movement;social stigma;social structure;socioeconomics;Stigmatization;structural determinants;substance use;Substance Use Disorder;System;theories;Time;tool;Training;transmission process;treatment as prevention;trend;USSR;Viral;Viremia


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Many prevalent neurodevelopmental disorders such as autism spectrum disorder, attention deficit hyperactivity disorder, and Tourette syndrome share common characteristics including impulsivity and repetitive action patterns. These behaviors may originate through the dysregulation of action control mechanisms, however, the circuit alterations that give rise to these action control deficits are not well understood. This proposal aims to provide valuable insight into the neural pathology involved in these disorders, as well as elucidate the neural mechanisms involved in normal action control regulation.

PI_NAMEs: FERRIGNO, SARAH  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Area;Attention deficit hyperactivity disorder;Auditory;autism spectrum disorder;Automobile Driving;Basal Ganglia;Behavior;Behavior assessment;Behavior Control;Behavioral;Biological Assay;Cell Adhesion Molecules;Cell Nucleus;Characteristics;Code;Copy Number Polymorphism;Corpus striatum structure;Cues;Data;Disease;disorder risk;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Dorsal;dorsal visual stream;Electrophysiology (science);Event;Exhibits;extracellular;Functional disorder;Ganglia;Genes;Gilles de la Tourette syndrome;Head;Impairment;Impulsivity;in vivo;insight;Knockout Mice;Medial;Mediating;Modification;Motor;Motor Activity;motor control;Motor Pathways;Mus;Mutant Strains Mice;Mutation;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;neuropsychiatric disorder;neurotransmission;novel;optogenetics;Output;Pathology;Pathway interactions;Pattern;Performance;Phenotype;Population;Prefrontal Cortex;presynaptic;Process;receptor expression;recruit;Regulation;Rewards;Risk;Running;selective expression;Site;Slice;Structure;Symptoms;Synapses;synaptic function;Task Performances;Techniques;Testing;Thalamic structure;treadmill;Variant;Water

PROJECT_TITLE: Exploring corticostriatal dynamics associated with action control deficits in Neurexin1 alpha mutant mice


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: COLLINS, LINDA M (contact)

PROJECT_TERMS: Acceleration;Address;Affect;AIDS prevention;Area;Awareness;Behavioral;behavioral and social science;biobehavior;Caring;Collaborations;Communicable Diseases;Communities;community based participatory research;community engaged research;Complex;Consultations;COVID-19 pandemic;Creativeness;Data;design;Disease Outbreaks;Disparity;Drug user;Epidemiology;ethnic minority population;Ethnography;Etiology;Evaluation;Event;Evidence based intervention;experience;Formulation;Geography;Goals;Health;health inequalities;HIV;Human Resources;implementation science;improved;Individual;Inequity;innovation;Intervention;Intervention Studies;Lead;Longevity;Measurement;member;Methodology;Methods;minority communities;Modeling;multidisciplinary;multiphase optimization strategy;novel;Pathway interactions;Personal Satisfaction;Population;Population Surveillance;prevent;Prevention;preventive intervention;Process;Public Health;Quality of life;racial minority population;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;resilience;Sampling;social;social structure;success;Testing;theories;therapy design;Time;Training;transmission process;trend;uptake;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Acceleration;Address;Affect;AIDS prevention;Applications Grants;Area;Award;Black, Indigenous, People of Color;care systems;career;Career Mobility;Caring;Communities;community collaboration;community engagement;Complex;COVID-19 pandemic;Development;Development Plans;Discrimination;Disparity;Drug usage;Drug user;economic disparity;Education;Epidemic;Equipment;equity, diversity, and inclusion;ethnic minority;Event;evidence base;Evidence based intervention;experience;food insecurity;Fostering;Funding;gender minority;Generations;Health;Healthcare;HIV;HIV Infections;HIV/AIDS;Housing;Imprisonment;Income;Individual;Inequality;Infrastructure;innovation;Interruption;Knowledge;Measures;member;Mentors;Mentorship;minority communities;Morbidity - disease rate;mortality;National Institute of Drug Abuse;next generation;novel;opioid epidemic;overdose prevention;pandemic disease;Participant;pedagogical content;personalized approach;Pilot Projects;Policies;Poverty;prevent;prevention service;Process;programs;Public Health;Quality of life;racial minority;recruit;Research;Research Design;Research Personnel;Resources;response;Rewards;Science;Scientist;screening;Services;sexual minority;skills;social norm;Social status;Stigmatization;Structure;substance use;Substance Use Disorder;Support System;Training;trend;Unemployment;United States National Institutes of Health;uptake;workforce needs;Writing


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE This proposal aims to study airborne transmission of SARS-CoV-2 and characterize the effects of innate and adaptive immune protection on transmission and dissemination of SARS-CoV-2.

PI_NAMEs: BOON, ADRIANUS CM (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;adaptive immune response;adaptive immunity;Adenovirus Vector;Aerosols;Affect;Agonist;Animal Model;Animals;Antibodies;Bar Codes;Binding;Cessation of life;COVID-19 susceptibility;COVID-19 vaccine;Data;Dose;emerging pathogen;Epitopes;Event;Evolution;Future;Gene Modified;Goals;Hamsters;Hour;Human;Immune;Immune response;Immunity;Immunization;Immunize;Immunoglobulin A;Immunoglobulin G;in vivo;Incubated;Individual;Infection;infection rate;influenzavirus;Innate Immune Response;Innate Immune System;insight;Interferons;Intramuscular;Kinetics;Location;Lower respiratory tract structure;Measures;Mesocricetus auratus;Modeling;Monoclonal Antibodies;Mucosal Immunity;Mucous Membrane;Mutation;Natural Immunity;neutralizing monoclonal antibodies;Pan Genus;particle;pathogenic virus;Persons;prevent;Process;protective effect;Proteins;Publishing;receptor binding;Recombinant Interferon;Recombinants;respiratory;respiratory virus;response;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;SARS-CoV-2 variant;Severity of illness;Social Distance;Societies;Testing;Time;transmission process;Upper Respiratory Infections;Upper respiratory tract;Vaccinated;vaccine delivery;Vaccines;Variant;variants of concern;Viral;viral transmission;Virion;Virus;Virus Diseases

PROJECT_TITLE: Transmission of CoV-2 and the Impact of Spike Protein Evolution

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This training program provides pre-doctoral students critical training opportunities in translational research ranging from mechanisms of disease to drug discovery and commercialization. Our goal is to increase the number of biomedical science trainees who enter the workforce with the skills needed to conduct innovative and translational research. This is of paramount importance for public health both from the perspective of understanding disease mechanisms and development of new therapeutics.

PI_NAMEs: KARTHIKEYAN, MYTHREYE ;PATEL, RAKESH P. (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: UAB Predoctoral Training Grant in Translational and Molecular Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Clinical Research;Heart Disease;Neurosciences;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The underlying mechanisms driving the relationship between prolonged ST and higher CVD risk in youth is unclear, but recent studies have begun to examine ST as it relates to cardiac ANS function since cardiac ANS imbalance is linked to adverse CVD outcomes. However, very few studies have examined the relationship between ST and cardiac ANS function in youth, and studies that have do not examine associations within a day or within a person, and do not experimentally manipulate prolonged ST. Therefore, this study will leverage data collection opportunities from an NIH-funded randomized control trial (P.I. Dr. Britni Belcher; R01DK12333) that will allow for the relationship between ST and cardiac ANS function (via heart rate variability metrics) to be investigated observationally within-day under free-living conditions and experimentally, in which it will be determined how interruptions in prolonged ST may influence cardiac ANS function in youth with OW/OB.

PI_NAMEs: MCALISTER, KELSEY LYNN (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acute;Affect;Age;Automobile Driving;Autonomic nervous system;Behavior Therapy;Behavioral;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Childhood;Cognition;Data Collection;Development;Devices;Disease Outcome;Disease Progression;Electrocardiogram;Equilibrium;Exercise;fighting;fitness;Frequencies;Funding;glucose metabolism;Health;Heart;Heart Rate;heart rate variability;high risk;Hour;improved;indexing;Individual;innovation;insight;Interruption;Intervention;Knowledge;Link;Measures;Mediating;Methodology;mortality;Nervous System Physiology;Obesity;Outcome;Overweight;Pathway interactions;Persons;Phase;Physical activity;Physiological;Physiological Processes;Population;Prevention;Public Health;Randomized, Controlled Trials;Research Design;Research Personnel;response;Rest;sedentary;System;Testing;Time;United States National Institutes of Health;Walking;Work;Youth

PROJECT_TITLE: Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Nutrition

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Chronic inflammation, and diseases that arise from chronic inflammation like atherosclerosis, benefit from vitamin D’s action on inflammatory suppression and active vitamin D (calcitriol, 1,25(OH)2D3) may be produced in nonrenal tissues in response to inflammation improving the disease condition. However, both the genomic mechanism for this regulation and clinical or animal evidence have remained elusive, therefore we seek to quantify the presence of calcitriol in nonrenal tissues in health and disease, investigate a mechanism for the inflammatory upregulation of the gene responsible for the enzymatic conversion to calcitriol, Cyp27b1, and define the biological benefits of local calcitriol production on atherosclerosis disease progression. Upon conclusion of these research studies, we will have defined a mechanism for Cyp27b1 regulation and vitamin D metabolite production in nonrenal tissues of the mouse in vivo, which will provide support for nonrenal calcitriol benefits and therefore may be clinically relevant in the design of human supplementation and studies aimed at disease onset prevention and/or amelioration of core symptoms during disease progression.

PI_NAMEs: MEYER, MARK B (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Acute;Animals;Anti-Inflammatory Agents;Arterial Fatty Streak;Atherosclerosis;Biological;Biology;Blood;calcification;Calcitriol;Cardiovascular Diseases;Cardiovascular system;Cells;Cessation of life;Chronic;Clinical;Clinical Trials;clinically relevant;Complement;COVID-19;CYP27B1 gene;design;dietary;Disease;Disease Progression;Dose;Endocrine;endoplasmic reticulum stress;Enhancers;Enzymes;Epigenetic Process;Foam Cells;follow-up;Gene Expression Regulation;Gene Modified;Genetic;Genomics;Health;High Fat Diet;Hormones;Human;Immune;Immune response;improved;in vivo;Infiltration;Inflammation;Inflammatory;insight;Interleukin-1 beta;Kidney;Knockout Mice;Knowledge;Macrophage;Malignant Neoplasms;Metabolic syndrome;monocyte;mouse model;Mus;Necrosis;nutrition;nutritional supplementation;Onset of illness;Outcome;Outcome Study;oxidized lipid;Patients;Populations at Risk;Prevention;Process;Production;programs;reduce symptoms;Regulation;research study;response;Rupture;Senile Plaques;Signal Transduction;skeletal;stem;Supplementation;Symptoms;Testing;Tissues;TNF gene;Transforming Growth Factor beta;Up-Regulation;uptake;Vitamin D;Vitamin D supplementation;Vitamin D3 Receptor

PROJECT_TITLE: Contribution of nonrenal calcitriol production in chronic inflammation

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Project Narrative Although the regulation of mRNA degradation contributes to gene expression patterns and can be highly complex, the extent of its impact on developmental gene expression remains largely unexplored. In addition, defects in mRNA degradation machinery result in distinct and severe developmental defects in model organisms and have been linked to diseases such as osteosarcoma and neurodegenerative diseases in humans, though whether such machinery function in specific developmental processes must be characterized. Here I propose an innovative strategy using bulk and single-cell RNA-sequencing and live cell imaging/automated lineage tracing to address these gaps in knowledge and provide a more comprehensive understanding of gene regulation during development by focusing on post-transcriptional regulation.

PI_NAMEs: PENG, FELICIA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Alternative Splicing;Animals;Auxins;Binding;Binding Proteins;Caenorhabditis elegans;Cell Culture System;cell fate specification;Cell Lineage;cell type;Cells;Codon Nucleotides;comparison control;Complex;Data;Data Analyses;Defect;Deposition;Development;Developmental Gene;Developmental Process;Disease;Dissociation;egg;Embryo;embryo cell;Embryonic Development;Ensure;Eukaryota;Exoribonucleases;exosome;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene product;Genes;Genetic Transcription;germline stem cells;Half-Life;Health;Human;Image;inhibitor;innovation;Invertebrates;Kinetics;Knowledge;Label;Link;live cell imaging;Maps;Maternal Messenger RNA;Measurement;Measures;Mediating;Messenger RNA;Metabolic;Methods;model organism;Modification;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;Nematoda;Neurodegenerative Disorders;Organism;Osteosarcoma;Pathway interactions;Pattern;Phenotype;Physiologic pulse;Polyadenylation;Post-Transcriptional Regulation;Process;progenitor;programs;Proteins;Regulation;Regulatory Element;Resolution;RNA;RNA Decay;RNA Degradation;RNA Polymerase II;RNA-Binding Proteins;Role;Shapes;single-cell RNA sequencing;Small RNA;spatiotemporal;Specific qualifier value;Specificity;System;temporal measurement;Testing;Time;Tissues;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transgenes;Transgenic Organisms;Translations

PROJECT_TITLE: The Role of mRNA Degradation in Embryonic Cell Fate Specification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project narrative Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with a five-year survival of less than 5%. Genomic analyses of human samples suggest that PDAC can be classified into at least two major subtypes based on cancer cell autonomous properties. The proposed research will investigate the molecular regulators of PDAC subtype and provide fundamental knowledge required for the design of therapeutic strategies that target PDAC on the basis of subtype-specific vulnerabilities.

PI_NAMEs: SNYDER, ERIC LEE (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: ATAC-seq;Biology;cancer cell;Cell Line;cell regeneration;chemotherapy;ChIP-seq;Classification;clinically relevant;cofactor;Data;design;Development;differential expression;Differentiation and Growth;Disease;Exhibits;experimental study;Family;Gene Expression;gene regulatory network;Genes;Genetically Engineered Mouse;Genomics;Goals;Growth;HNF4A gene;Homeobox;Human;In Vitro;in vitro Model;in vivo;insight;Knowledge;loss of function;Lysine;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;member;Mesenchymal;Molecular;molecular subtypes;mouse model;Mus;muscle progenitor cell;Normal tissue morphology;novel;Oncogenes;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;patient derived xenograft model;Pattern;Pharmaceutical Preparations;Play;Primitive foregut structure;progenitor;Prognosis;programs;Proliferating;promoter;Property;Protein Isoforms;Repression;Research;response;restraint;Role;Sampling;Specific qualifier value;stem cell function;stem cell proliferation;System;Testing;Therapeutic;Tissues;transcription factor;transcriptome;transcriptomics;tumor;tumor growth;Work

PROJECT_TITLE: Lineage specifiers governing pancreatic cancer growth and molecular subtype

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: Up to half of older U.S. military Veterans report chronic pain-related disabilities. In addition, military populations are developing degenerative pain conditions at much higher rates and at younger ages than civilians. There is a higher prevalence of chronic pain and opioid use reported in Veterans compared to civilian populations. Accordingly, Veterans treated chronically with opioids for their chronic pain may be vulnerable to developing opioid addiction (i.e. opioid dependence) and/or using illicit opioids to self-medicate pain symptoms. This project will examine overlapping brain biochemical mechanisms of chronic pain and opioid dependence that may contribute to the worsening and potential interdependence of these two disorders, with the ultimate goal of developing better therapeutic strategies for these devastating conditions affecting VA populations. Additionally, with the growing number of female Veterans treated by the VA for chronic pain issues, it is necessary to investigate new treatment opportunities for the benefit of both male and female Veterans.

PI_NAMEs: PAHNG, AMANDA ROSEMARY (contact)

PROJECT_TERMS: abuse liability;Academic support;Acute;addiction;Adult;Affect;Age;Agonist;American;Anabolism;animal pain;Animals;Attenuated;Award;Bathing;Behavior;Behavioral;behavioral pharmacology;biobehavior;Biochemical;Brain;career;career development;Cells;Central Nervous System Diseases;Chronic;Chronic inflammatory pain;chronic pain;chronic pain management;chronic pain patient;cost;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Dopamine;dopaminergic neuron;Dose;drug of abuse;Electrophysiology (science);experimental study;Female;Fentanyl;fentanyl self-administration;Fostering;Freund's Adjuvant;Future;Genetic;Genetic Techniques;Goals;High Prevalence;Hyperalgesia;illicit opioid;Impairment;innovation;Intake;Intravenous;Investigation;K-Series Research Career Programs;Knowledge;male;Measures;Mechanics;Mediating;Medical;Mentors;Mentorship;Military Personnel;military veteran;Modeling;Morphine;Motivation;neuronal excitability;Neurons;Nociception;novel therapeutic intervention;Nucleus Accumbens;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid use;Outcome;Pain;Pain management;Pain Measurement;pain sensitivity;pain symptom;pain-related disability;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Population;Positioning Attribute;pramipexol;pre-clinical research;Preparation;prescription opioid;prescription opioid addiction;Process;Productivity;Property;Rattus;receptor;receptor function;Reporting;Research;research faculty;Research Personnel;response;Rewards;Role;Scientist;Self Administration;Signal Transduction;skill acquisition;skills;Slice;Testing;Therapeutic;Training;transmission process;Treatment Cost;United States Department of Veterans Affairs;Ventral Striatum;Ventral Tegmental Area;Veterans;Whole-Cell Recordings;Withdrawal

PROJECT_TITLE: The Role of Mesoaccumbens Dopamine in Pain and Prescription Opioid Addiction


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Veterans who experience traumatic brain injury often have profound and debilitating sleep impairments impacting their mood, health, and overall well-being. The proposed experiments will determine how inflammatory molecular mechanisms in brain cells alter brain blood flow to affect sleep and brain wave dynamics. Findings from this proposal will aid in discovering novel therapeutic targets and approaches for sleep disturbances occurring in veterans with traumatic brain injury.

PI_NAMEs: ZIELINSKI, MARK ROBERT (contact)

PROJECT_TERMS: adeno-associated viral vector;Affect;Animal Model;Area;Arteries;Astrocytes;Binding;Blood Vessels;Brain;brain cell;brain dysfunction;Brain Injuries;C57BL/6 Mouse;Cell Separation;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive function;comorbidity;controlled cortical impact;Coupling;Cre lox recombination system;Data;density;design;Development;Devices;Electroencephalography;Encephalitis;Environment;Enzyme-Linked Immunosorbent Assay;Etiology;Excessive Daytime Sleepiness;Exhibits;experience;experimental study;Family;Flow Cytometry;Frequencies;Future;Gene Expression Profiling;Goals;Health;Healthcare Systems;hemodynamics;Hypothalamic structure;Immunohistochemistry;Impaired cognition;Impairment;improved;Incidence;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;Laser-Doppler Flowmetry;Leucine;Literature;marenostrin;Measurement;Measures;Microglia;Microspheres;mild traumatic brain injury;Molecular;Molecular Biology;Molecular Target;Moods;Mus;Myography;Neuroglia;neuroinflammation;Neurons;neurovascular;new therapeutic target;non rapid eye movement;novel;novel therapeutic intervention;nucleotide protein interaction;Nucleotides;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Personal Satisfaction;Phase;Physiological;Polysomnography;Process;Property;protein activation;protein complex;Quality of life;Regulation;Role;severe injury;Severities;Site;Sleep;Sleep disturbances;Sleep Fragmentations;Sleeplessness;Spectrophotometry;Techniques;Thalamic structure;Therapeutic;Time;transcriptome sequencing;Transgenic Mice;Traumatic Brain Injury;Travel;TXNIP gene;United States;Vascular resistance;Veterans;Veterans Health Administration;Viral Vector;Western Blotting;Work

PROJECT_TITLE: Inflammation, Neurovascular Hemodynamics, and Sleep in Traumatic Brain Injury


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Chronic pain is common among Veterans with poly-trauma, traumatic nerve injury, and traumatic limb amputation. While opioids are currently used for chronic pain, they are not very effective and carry serious side effects including the risk of addiction and abuse. We, and others, have discovered that peripheral voltage- gated sodium channels (NaVs) play a central role in human pain disorders, which has led to the pursuit of inhibitors of these channels as treatments that would avert central side effects. Although NaV channel blockers exist, they are of limited utility due to non-specificity and significant CNS effects. The goal of this project is to identify new targets toward the development of more effective treatments for chronic pain through the study of trafficking and polarized distribution of NaV channels within sensory neurons. The outcomes are expected to facilitate development of safer, more effective, and non-addictive treatments for chronic pain.

PI_NAMEs: DIB-HAJJ, SULAYMAN D;WAXMAN, STEPHEN  (contact)

PROJECT_TERMS: Action Potentials;addiction;Afferent Neurons;Aftercare;AGFG1 gene;Animal Model;Ankyrins;Applications Grants;Axon;Binding;Biogenesis;Calcium;Calcium Channel;Cell membrane;Central Nervous System Diseases;channel blockers;chronic pain;chronic pain management;Cytoskeleton;Deposition;Development;Diabetes Mellitus;Diabetic Neuralgia;Disease;Distal;effective therapy;Erythromelalgia;experimental study;Fiber;gabapentin;Glean;Goals;Human;improved;in vivo;in vivo evaluation;Inflammation;Inflammation Mediators;Inherited;inhibitor;Kinesin;knock-down;Knowledge;Label;Length;limb amputation;Link;Medical;Membrane;meter;Methodology;Mitogen-Activated Protein Kinases;Molecular;Monomeric GTP-Binding Proteins;Motor;Multiple Trauma;nanocluster;neuronal cell body;Neurons;Neuropathy;neurotransmitter release;Nociceptors;novel;novel strategies;Opioid;Outcome;Pain;Pain Disorder;Pain management;Paper;Patients;Peripheral;Phosphorylation;Play;pregabalin;presynaptic;protein transport;Proteins;Publications;real-time images;Recycling;Regulation;Risk;Role;Sensory;side effect;Sodium Channel;Sorting;Specificity;Speed;Surface;temporal measurement;therapeutic target;trafficking;Traumatic Nerve Injury;Traumatic Neuroma;Vesicle;vesicle transport;Veterans;voltage;Work

PROJECT_TITLE: Dynamic regulation of axonal trafficking and surface distribution of Nav1.7 in sensory neurons


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Cognitive deficits that occur with aging are a pervasive concern to older individuals and a growing public health issue and maintaining or improving cognition in older adults could have an important effect at the population level, potentially delaying the onset of Alzheimer’s disease and other dementias in millions of older adults. The goals of the proposed research are to first determine the minimal and/or optimal dose of a meditation-inspired digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovascular risk, and race/ethnicity). This knowledge gained from his high-impact study with transform the field of cognitive interventions, paving the way for a precision medicine model for cognitive enhancing interventions that improve quality of life for older adults and individuals with cognitive deficits at risk of developing dementia.

PI_NAMEs: GAZZALEY, ADAM H;ZIEGLER, DAVID A (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adolescent;Advanced Development;age related;Age Years;Aging;aging biomarker;aging population;Alzheimer's Disease;Atrophic;Attention;attentional control;Behavior;cardiovascular risk factor;Clinical;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive enhancement;Cognitive remediation;cohort;Country;Data;Dementia;design;digital;digital intervention;distraction;Dose;Ethnic Origin;Exhibits;experience;Experimental Designs;Explosion;follow up assessment;follow-up;functional decline;functional outcomes;General Population;Genetic;Goals;handheld mobile device;hazard;Human Characteristics;Impaired cognition;improved;indexing;Individual;individual variation;Intervention;Intervention Trial;Knowledge;Lead;Meditation;Memory impairment;Mental Health;Methodology;mild cognitive impairment;Modeling;Moods;neural;Neurodegenerative Disorders;neuropathology;novel;older adult;Older Population;Participant;Patients;Performance;Personal Satisfaction;pharmacologic;Physiological;Population;Populations at Risk;pre-clinical;precision medicine;prevent;Preventive therapy;primary outcome;Psychiatry;Public Health;Quality of life;Race;Randomized, Controlled Trials;Reaction Time;recruit;Regulation;Research;response;Risk;Sample Size;Sampling;social;Societies;Source;Stress;stress reactivity;stress reduction;Subgroup;success;sustained attention;Symptoms;telomere;treatment effect;treatment program;treatment response;vigilance;white matter;young adult

PROJECT_TITLE: Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adults


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Tuberculosis (TB) is the leading cause of death among people with HIV, with drug-resistant TB threatening decades of progress in TB and HIV control. Dr. Sarita Shah is a physician-scientist at Emory University whose research spans clinical, translational, and public health studies to reduce the burden of TB & HIV globally. This K24 award builds on her long-standing commitment to mentorship in patient-oriented TB & HIV research and will provide vital protected time to 1) expand her mentoring program for physicians and scientists who are pursuing these fields, and 2) enhance her knowledge of epidemiologic and genomic methods to aid in the understanding of drug-resistant TB transmission and prevention.

PI_NAMEs: SHAH, NIPPIE SARITA (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Affect;Area;Base Pairing;career;career development;Cause of Death;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Data;Clinical Research;Clinical Trials;Clonal Expansion;co-infection;Collaborations;Communicable Diseases;Communities;community setting;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;design;detection limit;Diagnosis;Disease;Drug resistance in tuberculosis;effective intervention;Ensure;Environment;Epidemic;epidemiologic data;Epidemiologist;Epidemiology;epidemiology study;experience;Extreme drug resistant tuberculosis;Foundations;Funding;Funding Opportunities;genome sequencing;Genomics;global health;Goals;Health;Health Policy;HIV;HIV/TB;Household;Immunology;improved;Incidence;Individual;innovation;insight;Interdisciplinary Study;interest;International;K-Series Research Career Programs;Knowledge;Lead;Link;Location;M. tuberculosis genome;mathematical model;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);Modeling;Molecular Epidemiology;Multi-Drug Resistance;multidisciplinary;Multidrug-Resistant Tuberculosis;mycobacterial;Mycobacterium tuberculosis;next generation;novel;novel diagnostics;novel therapeutics;Parents;Participant;Patient Care;patient oriented;patient oriented research;Pattern;Persons;Pharmacology;Physicians;Policies;prevent;Prevention;programs;Public Health;Research;Research Infrastructure;research study;resistant strain;Resources;Rifampicin resistance;Role;Science;Scientific Advances and Accomplishments;Scientist;skills;social;social contact;Social Mobility;South Africa;Specimen;Structure;success;Time;Training;training opportunity;transmission process;Treatment outcome;Tuberculosis;United States National Institutes of Health;Universities;whole genome;Work

PROJECT_TITLE: Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed, “Strengthening Child Health Research Capacity in Resource Constrained Settings” (referred to as Researcher Resilience Training, RRT) will deliver and test state-of-the-art methods training and “hands-on” research experience to advanced doctoral students and early career investigators, specifically those of African descent, committed to addressing the serious threats to child behavioral health (CBH) as well as prevention and care disparities in poverty-impacted local and global contexts. This short course will prepare RRT Fellows to focus their research on serious overlapping outcomes for youth living in scarce-resource communities: 1) disruptive behavioral difficulties; 2) engagement in early sexual/drug risk behaviors; and 3) early acts of delinquency, including violent behavior. RRT will develop and support a pipeline of new CBH investigators who are prepared to advance scientific knowledge about system and community-level structural interventions that can address the disproportionate health burdens experienced by poverty-impacted youth of African descent via enhancing protective family, neighborhood, system supports; reducing disparities; and advancing racial and health equity.

PI_NAMEs: JOE, SEAN ;MCKAY, MARY MCKERNAN (contact);SSEWAMALA, FRED M

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Africa;African;African ancestry;Area;Behavioral;behavioral health;career;Caregivers;Caring;Child;Child Health;Child Mental Health;child services;Child Welfare;cohort;Collaborations;Color;Communities;community burden;Consultations;COVID-19;Development;Disparity;disparity reduction;doctoral student;Educational process of instructing;Equity;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;Family;Funding;Goals;hands on research;Health;health disparity;health equity;Health Sciences;Home;Immersion;Individual;innovation;Institution;Instruction;international center;Intervention;Knowledge;Learning;Medicine;Mental Health;Mentors;Methods;Monitor;National Institute of Mental Health;Neighborhoods;novel;Outcome;peer;Pharmaceutical Preparations;Policies;Population;Poverty;Prevention;Provider;provider networks;Public Health;Publications;Race;Racial Equity;Racial Segregation;recruit;Research;Research Methodology;Research Personnel;research study;Research Support;resilience;Resource-limited setting;Resources;response;Risk Behaviors;safety net;scale up;Scientific Advances and Accomplishments;Scientist;Services;skills;Social Work;Specific qualifier value;Stress;Structural Racism;summer research;support network;Support System;System;systems research;Testing;Time;Training;Training Programs;United States National Institutes of Health;Universities;Violence;Washington;Youth

PROJECT_TITLE: Strengthening Child Health Research Capacity in Resource Constrained Settings: Researcher Resilience Training (RRT)


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative The Vanderbilt training program in Molecular and Genetic Epidemiology of Cancer is designed to build an elite class of epidemiologists to lead the new era of multidisciplinary collaborative research in cancer. The program, built upon an outstanding research and education training environment; excellent body of researchers and educators; multiple, ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and the rich history of interdisciplinary training at Vanderbilt, delivers individualized didactic and research training to equip postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey-research knowledge, and hands-on research and grant writing experience necessary to launch independent careers in the molecular and genetic epidemiology of cancer.

PI_NAMEs: SHU, XIAO-OU  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: cancer epidemiology;genetic epidemiology;Molecular Epidemiology;Training Programs

PROJECT_TITLE: Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE While clinical evidence demonstrates a unique “obese asthma” endotype that disproportionately affects women and is associated with poor health outcomes (treatment resistance, increased risk of morbidity/mortality), cellular alterations in the lungs that contribute to worsened lung dysfunction remain poorly understood. This application utilizes a novel model of obese asthma that more accurately mimics the human condition, and suggests that a unique cell population – mucosal associated invariant T (MAIT) cells – plays an important pathogenic role in obese asthma. Defining how MAIT cells influence asthma pathophysiology in obesity will not only spark innovative solutions for the treatment of asthma, but also contribute valuable knowledge to an underexplored cell type in the fields of immunology and metabolism.

PI_NAMEs: CANNATA, ANGELA MARIE (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Adipose tissue;Adoptive Transfer;Adult;Affect;Age of Onset;Allergens;Antigen Presentation;Asthma;asthma exacerbation;asthma model;asthmatic;Automobile Driving;biological sex;C57BL/6 Mouse;cell type;Cells;Cellular biology;Cessation of life;Child;Chronic;Clinical;cytokine;Data;design;Development;dietary control;Disease;disease model;Disproportionately impacts women;eosinophil;Experimental Models;feeding;Female;Frequencies;Functional disorder;Gene Expression Profiling;genetic manipulation;Genetic Models;gut inflammation;Heterogeneity;High Fat Diet;high standard;Homeostasis;Hospitalization;House mice;Human;human disease;human model;IL17 gene;Immune response;Immunology;improved;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;innovation;Knowledge;Licensing;Ligands;Liver;Lung;lung development;male;Metabolic;Metabolic dysfunction;Metabolism;migration;Modality;Modeling;Morbid Obesity;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;neutrophil;novel;Obesity;obesity-associated asthma;Outcome;Pathogenicity;Pathologic;Pathology;Pattern;Persons;Phenotype;Play;poor health outcome;Population;Production;protective effect;Public Health;pulmonary function;Pulmonary Inflammation;recruit;Research;Risk;Role;Severities;Signal Transduction;Symptoms;T-Lymphocyte;Temperature;Testing;Therapeutic;therapy resistant;Thinness;Time;Tissues;Weight Gain;women's outcomes

PROJECT_TITLE: Mucosal Associated Invariant T cells in the Obese-asthma endotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Pediatric;Prevention;Skin Cancer;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Relevance to Public Health: Health-related policy is an effective, yet underutilized, strategy for health promotion. To protect the public from melanoma and keratinocyte carcinomas, government bodies have begun to enact legislation to restrict minor access to indoor tanning and minimize harm from indoor tanning devices. In order to contribute to the currently limited evidence base for future policy decision making and sustainability and to accelerate reductions in indoor tanning and sunburn, moving toward an indoor tanning “endgame”, this project will address policy characteristics associated with regulation compliance, cost-benefits of these policies, and barriers and facilitators of policy adoption. !

PI_NAMEs: BULLER, DAVID B;HECKMAN, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Acceleration;access restrictions;Address;Adolescent and Young Adult;Adolescent Risk Behavior;Adopted;Adoption;Advocacy;Advocate;Affordable Care Act;Age;American;archived data;base;behavior change;Businesses;Case Study;Characteristics;comparative;Complex;Consent;Consumption;cost;Cost-Benefit Analysis;Costs and Benefits;Data;data integration;Decision Making;Devices;District of Columbia;economic cost;economic evaluation;Economic Factors;economic impact;economic implication;Economics;Elements;Employee;evidence base;experience;Future;Goals;Government;Harm Reduction;Health;Health behavior;Health Policy;Health Professional;Health Promotion;Home;Human Resources;improved;Incidence;Individual;informant;innovation;interest;Intervention;Interview;Investigation;Investments;Laws;Maintenance;Melanoma;Methodology;Methods;Minor;Outcome;Parental Consent;Parental Involvement Law;Parents;Policies;Policy Compliance;Politics;Populations at Risk;Prevalence;Prevention;Process;productivity loss;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regulation;Reporting;Research;Resources;Risk Behaviors;Risk Factors;Seminal;Skin Cancer;Skin Carcinoma;skin damage;Skin tanning;Smoking;societal costs;Statutes and Laws;Stream;Sunburn;Surveys;System;tanning booths;Taxation;Taxes;Teenagers;Tobacco;Translating;Ultraviolet Rays;United States Food and Drug Administration;young adult;Youth

PROJECT_TITLE: A Multi-Level Investigation of US Indoor Tanning PolicyEnactment, Implementation, Compliance, Impact, and Economics

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Hearing loss and tinnitus are the most common service-related disabilities for veterans. These disabilities span decades, conflicts, geographic location, and job descriptions. For those patients who have hearing loss too severe to benefit from hearing aids, cochlear implants offer a chance to regain some hearing and even understand speech without reading lips. However, current electrode technology cannot approach natural hearing. We propose applying living scaffold technology to the central and peripheral auditory system to create an implantable hearing device that provides more natural hearing than is possible with current technology. Living electrodes will be created by growing spiral ganglion neurons on to constructs designed to be implanted in the cochlea or auditory nuclei in the brainstem. These studies promise to deliver a significant advance in the ability to restore hearing to veterans, and people around the world.

PI_NAMEs: BRANT, JASON  (contact)

PROJECT_TERMS: Acoustic Stimulation;Affect;American;Auditory;Auditory area;auditory nuclei;auditory pathway;Auditory Perception;auditory rehabilitation;Auditory system;Axon;base;Behavioral;Behavioral Model;Biological;Brain;Brain Stem;career;Cell Survival;Cells;Clinical;Cochlea;Cochlear implant procedure;Cochlear Implants;Cochlear nucleus;Custom;deaf;design;design and construction;disability;efficacy evaluation;Electric Stimulation;Electrodes;Electrophysiology (science);Environment;Evaluation;Foundations;ganglion cell;Geographic Locations;Harvest;Hearing;Hearing Aids;hearing impairment;hearing restoration;Immunohistochemistry;Implant;implant design;implantation;improved;In Vitro;in vivo;Inferior;Inferior Colliculus;Job Description;K-Series Research Career Programs;Length;Light;Lipreading;Measurable;Microelectrodes;microstimulation;military veteran;multi-electrode arrays;Music;Neonatal;Nerve Degeneration;Nerve Regeneration;Nervous System Trauma;neural;neuronal cell body;Neurons;next generation;Noise;normal hearing;novel;Opsin;Optics;optogenetics;Patients;Peripheral;Personal Satisfaction;Persons;Phenotype;Population;Quality of life;Rattus;regenerative therapy;Rehabilitation therapy;Research Personnel;Residual state;restoration;Risk;round window;scaffold;Services;signal processing;Signal Transduction;simulation;Specificity;Speech;spiral ganglion;standard of care;Synapses;synaptogenesis;Technical Expertise;Techniques;Technology;Telephone;Temporal bone structure;Testing;Thinking;Tinnitus;Tissue Engineering;Transplantation;Veterans;Work

PROJECT_TITLE: Living electrodes for auditory rehabilitation.


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: Traumatic brain injury (TBI) is a leading cause of neurological complications including chronic memory deficits including dementia and tau pathology. Older TBI patients are at a higher risk for worsening of outcomes than their younger counterparts, despite the higher risk and worse outcomes, there are no targeted therapies for this susceptible population. This is compounded by data suggesting that older subjects may show less responsiveness to therapeutic interventions which may indicate that aged individuals will require specialized treatments that differ from young. In that regard, our lab has identified a novel cell free regenerative medicine therapeutic approach for TBI using exosomes (small vesicles secreted from cells) from human adipose derived stem cells, that have a therapeutic window up to at least 2 days after injury. This project will extend this promising finding and optimize this potential therapy for our elderly veterans’ population.

PI_NAMEs: BICKFORD, PAULA C (contact)

PROJECT_TERMS: Address;adipose derived stem cell;Age;aged;Aging;aging brain;aging population;Anti-Inflammatory Agents;Behavior;Biodistribution;Biological Process;Brain Injuries;cell motility;Cell secretion;Cell Separation;cell type;Cells;Chronic;Clinic;cognitive function;controlled cortical impact;Data;Dementia;Dose;Effectiveness of Interventions;Elderly;exosome;Flow Cytometry;Goals;high risk;Hour;Human;immune function;Immune system;Immunohistochemistry;Immunologic Memory;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Inflammatory Infiltrate;inflammatory marker;Injury;Innate Immune Response;Innate Immune System;Interleukin-6;Investigational Therapies;Ipsilateral;Knowledge;MALAT1 gene;Mass Spectrum Analysis;Measures;Memory impairment;Methods;Microglia;military veteran;Modeling;monocyte;Motor;Mus;nanoparticle;neurogenesis;Neurologic;NF-kappa B;novel;old mice;Outcome;Pathology;Peripheral;Persons;Phagocytosis;Phenotype;Play;Population;Predisposition;Proteome;Proteomics;Publications;regeneration function;Regenerative Medicine;repaired;Reporting;resilience;response;response to injury;RNA;Rodent;Role;Severities;targeted treatment;tau Proteins;TBI Patients;Therapeutic;Therapeutic Intervention;Translating;Traumatic Brain Injury;treatment optimization;treatment response;Untranslated RNA;Vesicle;Vulnerable Populations;Work

PROJECT_TITLE: Aging and Innate immune system resilience in TBI


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE The opioid epidemic has enormous consequences on the health and well-being of Veterans, Veteran families, and Veteran communities. Opioid addiction is propelled by opioid-induced changes in brain circuits that control reward and aversion, and pharmacological or other neuromodulatory therapies that reverse opioid-induced changes are sorely needed. This proposal will systematically identify where and how the actions of opioids act on ventral pallidum and connected brain circuits to cause changes that underlie reward-seeking and punishment-avoidance behaviors.

PI_NAMEs: HNASKO, THOMAS  (contact)

PROJECT_TERMS: Abstinence;addiction;Affect;Analgesics;Anatomy;approach behavior;Attention;Aversive Stimulus;avoidance behavior;Behavior;behavior change;Behavior Control;Behavioral;behavioral response;Brain;Cell Physiology;cell type;Cells;Communities;Complex;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Electrophysiology (science);experimental study;Family;Fiber;Foundations;Future;gamma-Aminobutyric Acid;Globus Pallidus;Glutamates;Health;in vivo;Knowledge;life span;Literature;Maps;Measures;Mediating;Midbrain structure;Motivation;mouse genetics;mu opioid receptors;Mus;neural circuit;Neurons;neuroregulation;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;Opioid replacement therapy;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Output;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Photometry;Physiological;Population Heterogeneity;Process;Psychological reinforcement;Public Health;Punishment;Receptor Activation;relapse risk;response;Rewards;Role;Signal Transduction;Slice;Synapses;Synaptic Transmission;targeted treatment;Testing;therapeutic development;tool;Ventral Tegmental Area;Veterans;Viral Vector;Vulnerable Populations;Weaning;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Midbrain neural circuit mechanisms underlying addiction


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Diet and the microbiome are important risk factors for the development of chronic diseases - cancers, inflammatory bowel diseases, obesity, and type 2 diabetes - and influential modulators of glucuronidation, an essential detoxification pathway. Metabolomics and metagenomics are top-down techniques, which facilitate the identification and quantification of metabolites in complex mixtures (blood, urine, and stool) and the distribution and frequency of microbial genes, respectively. The proposed research aims to integrate high-throughput -omics techniques and traditional molecular assays to define the glucuronidome under normal and disrupted conditions and identify the physiologic effects of shifting glucuronide pools on host inflammation, metabolism, and disease development.

PI_NAMEs: BOYLE, NINA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;adverse drug reaction;Affect;Antibiotic Therapy;Antibiotics;Aryl Hydrocarbon Receptor;Beta-glucuronidase;Bile Acids;Biological;Biological Assay;Blood;Blood specimen;C57BL/6N Mouse;Carcinogens;chemical addition;Chemicals;chemotherapy;Chronic Disease;Chronology;Colon;Colon Carcinoma;Complex Mixtures;constitutive androstane receptor;Cytochrome P450;Data;Databases;Development;Diagnosis;Diet;dietary;Digestion;Disease;Drug Metabolic Detoxication;drug metabolism;Drug Prescriptions;Enterohepatic Circulation;Enzymes;Epithelium;Excision;experimental study;Fatty Acids;Feces;Frequencies;Gene Expression;Genes;Genomics;Germ-Free;Glucuronic Acids;Glucuronides;Glucuronosyltransferase;Goals;gut microbiome;Health;Hormones;host microbiome;improved;in vivo;individualized medicine;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Influentials;insight;Intestinal permeability;Intestines;Knowledge;Ligands;Liver;Long-Term Effects;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;metabolomics;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial community;microbiome;microbiome analysis;Molecular;Molecular Biology Techniques;multiple omics;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;Non-Steroidal Anti-Inflammatory Agents;novel;Nutrient;Obesity;Outcome;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiological;pregnane X receptor;Prevention;Process;public database;Qualifying;receptor;reconstitution;Regulator Genes;Research;Research Proposals;Risk Factors;Role;sample collection;Sampling;side effect;Signal Transduction;skills;stool sample;Stress;Structure;targeted treatment;Taxonomy;Techniques;Toxic effect;toxicant;Training;transcription factor;Treatment Efficacy;Ulcer;United States;urinary;Urine;Vitamins;water solubility;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Mapping the Glucuronidome


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE This research examines the long-term effects of the COVID-19 pandemic on health care delivery, quality and equity for people living with multiple chronic conditions. In a unique national community health center practice “laboratory” caring for more than 2.6 million patients, time-series analyses will reveal the evolution of practice innovations such as telehealth, integrated mental health services, and patient outreach, and will discover their effect on patient care quality and equity. Comparative case studies sampled from the quantitative data will identify and characterize transportable practice innovations to advance equity of care for health disparity populations living with multiple chronic conditions.

PI_NAMEs: COOK, NICOLE JILL;STANGE, KURT C (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;acute care;Adoption;Affect;African American;Area;Back;Caring;Case Study;Chronic Care;Chronic Disease;Communities;Community Health Networks;comparative;Computerized Medical Record;Consumption;Country;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Decision Making;Depression screen;Disasters;Disease;Disparity;disparity reduction;Electronics;Equitable healthcare;Equity;Evolution;Face;Family;follow-up;Fostering;functional status;Health;health care delivery;health care disparity;health care quality;health disparity populations;health inequalities;Healthcare;Healthcare Systems;high risk;Human;improved;Information Technology;innovation;insight;interest;Intervention;Interview;Knowledge;Laboratories;Language;Latino;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Long-Term Effects;low socioeconomic status;Medicaid;Mental Health Services;Movement;multiple chronic conditions;Natural Disasters;Neighborhood Health Center;novel;older adult;Outcome;outreach;pandemic disease;pandemic impact;Patient Care;patient outreach;patient registry;Patient-Focused Outcomes;Patients;Persons;Policies;practice-based research network;Preventive measure;Primary Care;Primary Health Care;Process;Provider;Public Health;Quality of Care;Refugees;remote visit;Reporting;Research;Resources;response;Rural Health Centers;safety net;Sampling;Sampling Studies;Seasonal Variations;secondary analysis;service delivery;social health determinants;stay-at-home order;Subgroup;System;telehealth;Time;Time Series Analysis;tool;Visit

PROJECT_TITLE: Long-Term Effects of COVID-19 and Health Care Delivery Changes on Health Disparity Populations Living with Multiple Chronic Conditions

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Sepsis

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Sepsis kills 11 million people every year and early identification and treatment are the only known ways to improve mortality. We currently focus on treating people once they get to the hospital or emergency department, which is often too late. This study will evaluate opportunities to identify and triage patients who may be at high-risk of sepsis before they get to the hospital.

PI_NAMEs: LIU, VINCENT  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accident and Emergency department;Address;Artificial Intelligence;Caring;Cessation of life;Clinical;cost;Data;design;Diagnostic;Early identification;Early treatment;Electronic Health Record;frontier;Future;Goals;Health system;high risk;Hospital Departments;Hospitals;improved;improved outcome;Infection;Informatics;innovation;Intervention;Intervention Studies;machine learning method;Modality;mortality;novel;Patient Triage;Patients;Performance;Persons;predictive modeling;prevent;programs;prospective;Public Health;Research;risk stratification;screening;Sepsis;septic patients;Subgroup;Testing;Time;treatment guidelines

PROJECT_TITLE: Identifying pre-sepsis opportunities for early, targeted intervention


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE: This proposal describes the development and implementation of theranostic PET imaging and radionuclide therapy agents targeting CD46, an exciting new therapeutic target which is highly expressed in multiple myeloma. We will optimize this strategy in preclinical models, developing co-treatment methods to maximize sensitivity. A pilot translational study of the PET imaging agent will be used to detect CD46 expression in patients with multiple myeloma, setting the stage for widespread clinical translation of these techniques.

PI_NAMEs: FLAVELL, ROBERT RICHARD (contact);WIITA, ARUN P.

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Animal Model;Antibody-drug conjugates;Antigens;Award;Binding;Biodistribution;CD46 Antigen;Cells;Characteristics;Chromosomes;clinical translation;Clinical Trials;cold agglutinins;Combined Modality Therapy;CRISPR interference;Data;Detection;detection sensitivity;Development;Disease;Dose;Eligibility Determination;Epitopes;experience;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Genes;genome-wide;Genomics;Goals;Human;human model;Image;imaging agent;imaging scientist;imaging study;Immunoglobulin G;improved;in vivo;in vivo evaluation;Isotopes;Length;Magnetic Resonance Imaging;Malignant Neoplasms;Maximum Tolerated Dose;Methods;Modeling;molecular imaging;Molecular Target;Morbidity - disease rate;mortality;Multiple Myeloma;Mus;neoplastic cell;new therapeutic target;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Patient Care;Patients;Performance;PET/CT scan;Phase I Clinical Trials;Physicians;Pilot Projects;pomalidomide;Population;Positron;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Preclinical Testing;Protocols documentation;Radiolabeled;Radionuclide therapy;Radiopharmaceuticals;Recording of previous events;Refractory;Relapse;Scanning;screening;Signal Transduction;Site;standard of care;Surface;targeted agent;targeted treatment;Techniques;Testing;theranostics;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;translational study;treatment strategy;tumor;Xenograft Model

PROJECT_TITLE: Development of CD46 theranostics for imaging and treatment of multiple myeloma

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Methamphetamine;Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Mammalian pacemakers located outside of the suprachiasmatic nucleus have not been studied in-depth. The goals of this project are to discover the neural circuitry and functional significance of these under-studied circadian pacemakers. Understanding how these enigmatic circadian pacemakers augment our current model of the circadian system will provide new ways to prevent, diagnose, and treat human disorders that are caused by, or lead to, circadian disruption.

PI_NAMEs: YAMAZAKI, SHIN  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Anatomy;Area;Behavior;Behavioral;Body Temperature;Brain;Cell Nucleus;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Coupled;Cre driver;Data;Diagnosis;disabled;Disease;Dissociation;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;Dose;Drug Addiction;Exhibits;Exposure to;Feedback;feeding;Food;Food Intake Regulation;Goals;Health;Human;human disease;Hypothalamic structure;Image;Impairment;inducible Cre;insight;Knockout Mice;Knowledge;Lead;Light;Location;LoxP-flanked allele;Mammals;Maps;Melatonin;Methamphetamine;Methodology;Microscopy;Modeling;Molecular;molecular assembly/self assembly;Motor Activity;Mus;Nervous System Disorder;neural;neural circuit;neural network;Neurons;novel;Organ;Organism;Output;Pacemakers;Patients;Periodicity;Peripheral;Persons;Phase;Physiological;Physiological Processes;Physiology;prevent;Process;promoter;Prosencephalon;Rewards;Risk;Rodent;Role;Running;shift work;Signal Transduction;Sleep;Sleeplessness;Slow-Wave Sleep;small hairpin RNA;Stimulant;Stimulus;suprachiasmatic nucleus;System;Technology;Tertiary Protein Structure;Testing;Time;Tissues;Transgenes;two-photon;Visualization

PROJECT_TITLE: Neural circuitry and functional significance of extra-SCN pacemakers

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative We seek support for the established graduate training program at Ohio State University (OSU) in Cellular, Molecular and Biochemical Sciences (CMBP). This program involves 39 faculty trainers from four related molecular life sciences graduate programs who represent the highest standards of teaching and research excellence at OSU. The CMBP provides unique opportunities for training a diverse cohort of students that integrates career-advancing components with excellence in scientific research, positioning graduates to make significant contributions to biomedical research in academia, government, and industry.

PI_NAMEs: JACKMAN, JANE ELIZABETH;MUSIER-FORSYTH, KARIN M (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Cellular, molecular, and biochemical sciences training grant

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: One of the most significant impediments to the discovery of new medicinal agents is the inability to assemble complex molecules rapidly, efficiently, and with predictable outcomes. This proposal aims to address a number of major technological gaps in the field of organic synthesis through innovations in catalysis, which will greatly accelerate the preparation of medicinal lead structures.

PI_NAMEs: LAMBERT, TRISTAN H (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: CATALYTIC PLATFORMS USING AROMATIC IONS AND OTHER CHARGED SPECIES