NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Digestive Diseases;Disability Research;Dissemination and Implementation Research;Mental Health;Neurosciences;Pain Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Severe and disabling abdominal pain is common in individuals with chronic pancreatitis. Although pain is associated with reduced quality of life and high economic and societal costs, there are limited effective options for pain management in this population. This study proposes an evidence-based psychological intervention approach using an internet-delivered cognitive-behavioral program to minimize the impact of pain and improve quality of life. The ultimate goal is to maximize the public health impact of the intervention with successful implementation and dissemination to pancreas clinics and to the community.

PI_NAMEs: CONWELL, DARWIN LEWIS;PALERMO, TONYA M (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Acute;acute pancreatitis;Address;Anxiety;anxiety symptoms;Behavioral;Chronic;chronic pain;chronic pain management;chronic painful condition;chronic pancreatitis;Clinic;Clinical Cancer Center;clinical center;Clinical Trials;Cognitive;Cognitive Therapy;cohort;common symptom;Communities;community setting;cost;Coupled;Data;depressive symptoms;design;Diabetes Mellitus;disability;Disabling;Disease;Dissemination and Implementation;economic cost;Economics;Education;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;Enrollment;Evaluation;evidence base;Evidence based intervention;experience;follow-up;Foundations;future implementation;Gastrointestinal Diseases;Goals;health care disparity;health related quality of life;Healthcare;Hospitalization;Hybrids;implementation facilitators;improved;Individual;internet delivery;Intervention;Interview;Investigation;Learning;Malignant neoplasm of pancreas;Mental Depression;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;non-opioid analgesic;Nonpharmacologic Therapy;Observational Study;Operative Surgical Procedures;Opioid;opioid use;Pain;Pain interference;Pain management;pain outcome;pain reduction;Pain Research;pain self-management;Pancreas;Pancreatitis;patient advocacy group;Patient Outcomes Assessments;Patients;Phenotype;Physical Function;Population;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Pragmatic clinical trial;Preparation;prescription opioid;primary outcome;Process;process evaluation;programs;prospective;Provider;psychologic;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;Recurrence;Relaxation;Resources;Risk;secondary outcome;Severities;side effect;skills;Sleep disturbances;sleep quality;social health determinants;societal costs;Structure;Symptoms;treatment effect;treatment response;United States;United States National Institutes of Health;web site

PROJECT_TITLE: Internet-Delivered Pain Self-Management to Reduce Pain and Interference in Chronic Pancreatitis

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative  Retinal degenerative diseases are the leading cause of irreversible vision loss. Retina prosthesis are implantable devices designed to stimulate sensation of vision in the eyes of individuals with these significant conditions. In this application, we aim to develop an optoacoustic micro-lens array as an implant offering massively parallel and high precision optoacoustic stimulation as genetics-free retinal prosthesis with translational potential to human.

PI_NAMEs: YANG, CHEN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: biomaterial compatibility;Blindness;Brain;Cells;Chemicals;Cicatrix;clinical translation;Clinical Trials;Complex;Coupled;cranium;Data;density;design;Development;Device Designs;Devices;digital;electric impedance;Electrodes;Electrons;Electrophysiology (science);Elements;Esthesia;Eye;Fiber;Film;flexibility;Focused Ultrasound;Foundations;General Hospitals;Genetic;Human;Image;Implant;implant design;implantable device;improved;in vivo;Individual;Intervention;Label;Lasers;Legal;lens;Lighting;Magnetism;Measurement;Medical;medical schools;meter;Methods;multi-electrode arrays;multidisciplinary;Mus;nanomaterials;Natural regeneration;neural;neural circuit;Neurons;neuroregulation;new technology;non-genetic;noninvasive brain stimulation;patch clamp;Pattern;Penetration;Performance;Physiologic pulse;Prosthesis;Resolution;response;Retina;retina implantation;Retinal Degeneration;Retinal Ganglion Cells;retinal prosthesis;retinal stimulation;scale up;Scheme;sight restoration;Source;Technology;technology platform;Testing;tissue culture;Tissues;translational potential;ultrasound;United States;Vision

PROJECT_TITLE: Massively Parallel Optoacoustic Retinal Stimulation at Micrometer-Resolution


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cardiovascular;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Infectious Diseases;Obesity;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Among ethnic groups in the US, African Americans continue to display some of the most disparate health outcomes. This proposal will interrogate the functional effects and druggablity of under-studied gene variants related to immune and drug response within the genome of individuals of African ancestry (AAs). This project has the potential to strengthen our understanding of ancestry-related host immunity as a contributor to the biology of health disparities.

PI_NAMEs: KIMBRO, KEVIN SEAN (contact);NAVARRO, HERNAN A;WILLIAMS, KEVIN PETER

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Address;African American population;African ancestry;Aftercare;American Association of Cancer Research;Amino Acid Sequence;Asthma;Biological;Biological Assay;Biological Factors;Biology;Cancer Death Rates;cancer health disparity;Cancer Patient;Cardiometabolic Disease;Cardiovascular Diseases;Cell Line;Cells;Clinical Trials;Code;Colorectal Cancer;Communicable Diseases;Complex;COVID-19;Development;Diagnosis;Disease;disease disparity;Disease Marker;Drug Interactions;effective therapy;Engineering;Environment;ethnic minority;Ethnic Population;European ancestry;Evolution;Family;Food Supply;Genes;Genetic;genetic variant;Genome;Geography;health disparity;health outcome disparity;Heart Diseases;Human;Hypertension;Immune;Immune response;Immunity;Immunologic Markers;in silico;In Vitro;in vitro testing;in vivo;Indigenous;Individual;individual patient;Infant Mortality;Inflammation;innovation;insight;Knowledge;knowledge base;Lead;Life Expectancy;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;microbial;Modeling;Molecular Target;Mutation;Neurodegenerative Disorders;novel;Obesity;Participant;pathogen;patient response;Pattern;Pharmaceutical Preparations;population based;Predisposition;pressure;Prognosis;Progress Reports;Proteins;Public Health;racial minority;Research;response;Role;screening;Socioeconomic Factors;Temperature;Therapeutic;Therapeutic Agents;Variant

PROJECT_TITLE: Addressing the Biology of Health Disparities by Targeting Geographical Ancestry-driven Variants of Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The correlation between numerous EEG features and Alzheimer’s Disease progression and fundamental biomarkers makes the EEG a compelling candidate for an early “digital biomarker” of AD. Over the past few years, our lab has made significant strides in developing advanced neural signal processing methods to enhance the precision of EEG-derived measures, facilitate more precise, individualized EEG biomarkers. Through this project, we aim to provide the AD research community with a suite of powerful, accessible signal processing software tools that will dramatically enhance the precision and quality of EEG-derived biomarkers designed to provide early detection and tracking of AD progression.

PI_NAMEs: PURDON, PATRICK L. (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Articulation;Biological Markers;biomarker development;Brain;Clinical;clinical application;Clinical Trials;Cognitive;cognitive performance;Communities;Data;Data Analyses;design;Development;Device or Instrument Development;Digital biomarker;digital technology;Disease Progression;Early Diagnosis;Electroencephalography;EP300 gene;Error Sources;Event-Related Potentials;Frequencies;Goals;improved;Individual;innovation;insight;interest;learning algorithm;Magnetic Resonance Imaging;Markov Chains;Measurement;Measures;Methods;Modeling;Morphologic artifacts;National Institute on Aging;Nerve Degeneration;neural;Neurobehavioral Manifestations;neuroimaging marker;neurophysiology;neurotransmission;Noise;non rapid eye movement;novel;older adult;Pharmaceutical Preparations;Phase;Population;Research;response;Rest;signal processing;Signal Transduction;Sleep;Software Tools;Source;source localization;Space Models;spatial relationship;Structure;task analysis;tau Proteins;Technology;Therapeutic;Thick;Time;tool;Variant

PROJECT_TITLE: Advanced signal processing methods for neural data analysis to support development of brain dynamic biomarkers for research and clinical applications in patients with Alzheimer's and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS STATE DEPARTMENT OF HEALTH

ORG_STATE: AR

PHR: Arkansas Department of Health's Rapid Response Team Building Project (RRT)  Project Narrative The Arkansas Department of Health is submitting an application for three years development funding for a Rapid Response Team (RRT). The total amount of the funds requested for the project is $524,066.17. Funds will support a full-time RRT coordinator, training, travel, and all associated support for developing a RRT.

PI_NAMEs: FRUECHTING, PHILLIP  (contact)

PROGRAM_OFFICER_NAME: ANDREWS, THANH


ORG_CITY: PHOENIX

ORG_NAME: ARIZONA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: AZ

PHR: The Development and Maintenance of Human and Animal Food Rapid Response Teams  Funding Opportunity Announcement (FOA): RFA-FD-23-019 Arizona Rapid Response Team Development  Project Narrative There are 8 different objectives outlined in the FOA: RFA-FD-23-019 that the AZDA will focus on achieving throughout the next 3 years. Key milestones are indicated for each objective. Each year the AZDA intends to achieve target goals to bring us closer to the overarching mission of developing a multi-agency, multi-disciplinary team that will operate utilizing Incident Command System (ICS) and National Incident Management System (NIMS) principles and a Unified Command structure to respond to HAF emergencies. We expect to effectively minimize the time between agency notification of HAF incident and implementation of effective control measures.

PI_NAMEs: LOPEZ, TERESSA M (contact)

PROJECT_TITLE: Arizona Rapid Response Team Development


ORG_CITY: RICHMOND

ORG_NAME: VA ST DEPT/ AGRICULTURE & CONSUMER SRVS

ORG_STATE: VA

PHR: Virginia Rapid Response Team Project Narrative:  Virginia Rapid Response Team (VA RRT) was created to ensure investigators are trained and work as a multi-agency, multi-disciplinary team to promptly respond to and investigate foodborne outbreaks or other events involving contamination of human or animal food. The VA RRT is composed of a core team with members representing the Virginia Department of Agriculture and Consumer Services (VDACS): Food Safety Program (FSP), Dairy Program, and the Agriculture Commodities Program (Animal Feed), the Virginia Department of Health (VDH): Epidemiology and Surveillance (EPI), Environmental Health (EH), and Shellfish Program, the Department of General Services (DGS) state lab Division of Consolidated Laboratories (DCLS), the United States Department of Agriculture Food Safety Inspection Services (USDA FSIS) and the United States Food and Drug Administration Baltimore District /Human and Animal Food 2East (FDA HAF 2E). Membership in the VA RRT core team has been updated to include members of the VDACS Produce Safety Program and VDH Water Safety Program. VA RRT core team members meet through a weekly scheduled conference call which provides updates form each agency and program. The VA RRT core team decides how to response to each update by providing resources (sampling supplies and equipment, Personal Protective Equipment) or to activate using modified Incident Command System (ICS)/National Incident Management System (NIMS) principles and a Unified Command structure to provide a rapid and unified all hazards response to human and animal food emergencies.  The VA RRT uses the resources and partnerships developed through the cooperative agreement to continuously improve interagency communication, develop and implement established procedures for operations including joint investigations to minimize the social, economic, and public health impacts of human and animal food. Continued support of the cooperative agreement provides resources and regularly held joint training and exercises to ensure the multiagency all hazards team is properly trained and ready to complete a variety of essential task during an VA RRT activation response.

PI_NAMEs: MILES, PAMELA W (contact)

PROJECT_TITLE: Progress of Strategies Developed and Implemented to Maintain a Human and Animal Food Rapid Response Team


ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: KS

PHR: Kansas Human and Animal Food Rapid Response Team Project Narrative The Kansas RRT will enter the maintenance phase of developing an all-hazards food and feed protection program in collaboration with other state RRT and FDA partners. The mission of the Kansas RRT is to effectively respond to foodborne outbreaks and identify potential preventative practices to protect the food supply and consumer health nationally and globally.

PI_NAMEs: GRISAMORE, AMBER A (contact)

PROJECT_TITLE: The Kansas Department of Agriculture's Maintenance of Human and Animal Food Rapid Response Team


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WINSTON-SALEM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Rural Americans experiencing a heart attack, called an ST-Elevation Myocardial Infarction (STEMI), are less likely to receive timely treatment than their urban counterparts, which exposes them to excess morbidity and mortality. Based on our team’s foundational work that identified critical gaps in STEMI emergency care, this proposal will develop, implement, and refine a smart-device application to support clinical decisions for rural STEMI care by EMS providers, which in turn will improve care timeliness and quality. Through a two-phase implementation strategy in a total of 8 rural EMS agencies, we will build and then evaluate the Rural STEMI App’s ease of use and ability to improve outcomes.

PI_NAMEs: MAHLER, SIMON A (contact);MANNING, JOHN D

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Digital EMS Point of Care Innovation to Improve Rural STEMI Outcomes

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT HLTH/HUMAN RSCS

ORG_STATE: WV

PHR: West Virginia Foodborne Illness Rapid Response Team  Project Narrative During project period 1, WV RRT will participate in the 2023 National Scout Jamboree in Glenn Jean, WV. In project period 2 the after-action report will be from a tabletop exercise that focuses on responding to outbreak caused by product recalled nationally that was used as an ingredient by home food business it will be called “My House is Your House.” The third project period exercise will be a tabletop exercise that demonstrates how complaint collection to a centralized system can help identify outbreaks within the state.

PI_NAMEs: KING, DANIELLE  (contact)


ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

PHR: Project Narrative Through this cooperative agreement, the Massachusetts Department of Public Health, Bureau of Environmental Health/Food Protection Program will maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS) and will support continuation of its Rapid Response Team’s (RRT) capacity to respond to food/feed incidents. The Massachusetts MFRPS Program will continue to ensure and maintain best public health practices for a high-quality regulatory program to reduce foodborne illness hazards in plants that manufacture, process, pack, or hold foods. The Massachusetts RRT Program will support and facilitate long-term improvements and innovation to the national integrated food safety system by unifying and coordinating federal/state/local human and animal food (HAF) emergency response efforts through the following: strong linkages between epidemiology, laboratory, and environmental health/regulatory programs and staff; implementation of Incident Command System (ICS)/National Incident Management System (NIMS) principles and a Unified Command structure to conduct integrated responses to all-hazards HAF emergencies; and the incorporation of training, data sharing, data analysis, communications, and development of best practices and other resources to support national capacity/capability development.

PI_NAMEs: MOORE, MICHAEL J (contact)

PROJECT_TITLE: Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Massachusetts FPP


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative The oncogenic transcription factor MYCN drives a subset of neuroblastoma tumors which is deadly in half the cases despite protracted and intense therapy including polychemotherapy and immunotherapy (anti-GD2 therapy). As MYCN remains undruggable, finding synthetic lethal relationships that may result in new treatments is one of the “holy grails” of pediatric cancer therapy. In this grant proposal, we provide evidence that amplified MYCN orchestrates a complex and intricate re-wiring of the neuroblastoma cell to 1) increase iron metabolism, 2) increase cysteine and selenocysteine biosynthesis to counteract reactive oxygen species created from iron metabolism-related Fenton reactions and 3) increase synthesis of pantothenate kinase 3 (PANK3) to subsequently increase coA levels; the result of which is the creation of a synthetic lethality and therapeutic vulnerability to ferroptosis induction which we aim to explore, clarify and translate to new therapeutic options for this recalcitrant pediatric tumor.

PI_NAMEs: FABER, ANTHONY CHARLES (contact);OLZMANN, JAMES A

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: aged;Anabolism;Antioxidants;Apoptosis;Apoptotic;Applications Grants;BCL1 Oncogene;BCL2 gene;Biological;cancer cell;cancer therapy;Cell Culture Techniques;Cell Death;Cell Line;Cells;Chemicals;Child;Clinic;Clinical;Clinical Investigator;Coenzyme A;combat;Combination Drug Therapy;Combined Modality Therapy;Complex;Cysteine;Dependence;Disease;disorder risk;Drug Metabolic Detoxication;Drug Targeting;experimental study;FDA approved;Genetic;Genetic Screening;Genomics;Glutathione;glutathione peroxidase;Goals;Grant;Growth;high risk;Immunotherapy;improved;in vivo Model;inhibitor;Iron;iron metabolism;kinase inhibitor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;MYCN gene;Nature;Neuroblastoma;neuroblastoma cell;new combination therapies;novel;novel therapeutics;Oncogenes;Oncogenic;Oxygen;Pantothenate kinase;Pantothenic Acid;Pathway interactions;patient derived xenograft model;Patients;Pediatric Neoplasm;Peroxidases;Pharmacologic Substance;Phenotype;Phosphotransferases;pre-clinical;Production;programs;Proliferating;Reaction;Reactive Oxygen Species;Refractory;Relapse;Research Design;Resistance;resistance mechanism;response;screening;Selenocysteine;selenoprotein;Stress;Testing;Therapeutic;Time;transcription factor;Translating;translational medicine;Translational Research;treatment response;tumor;Work

PROJECT_TITLE: MYCN drives a ferroptotic vulnerability in neuroblastoma


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE OVERALL COMPONENT Alzheimer’s disease is a major cause of death and disability in the United States and the National Alzheimer’s Project Act seeks to identify a treatment or prevention for Alzheimer’s disease (AD). In order to meet this ambitious goal, the interdisciplinary Indiana University/Jackson Laboratory/University of Pittsburgh (IU/JAX/PITT) MODEL-AD Center seeks to continue generating and characterizing novel animal models of AD, assessing the relevance of these to model to human disease, and developing a precision preclinical testing pipeline through which novel therapies can be tested to greatly accelerate the process by which therapies are successfully moved forward to human AD clinical trials. Importantly, the IU/JAX/PITT Center will generate new AD modeling processes and pipelines, data resources, research results and models that will be swiftly shared via existing infrastructure at the participating institutions and through the AD Knowledge Portal, academic medical centers, research institutions and the pharmaceutical industry worldwide.

PI_NAMEs: CARTER, GREGORY W;HOWELL, GARETH R;LAMB, BRUCE T (contact);OBLAK, ADRIAN LYNN;RIZZO, STACEY J;SASNER, MICHAEL ;TERRITO, PAUL RICHARD

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Animal Disease Models;Animal Model;apolipoprotein E-4;Behavior;Bioinformatics;Biological;Biological Markers;Biological Models;Cause of Death;Cessation of life;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Data;Data Analyses;data management;data modeling;data resource;Data Set;data sharing;Dedications;Dementia;Development;disability;Disease;disease model;Drug Industry;Drug Kinetics;drug testing;Elderly;Engineering;Ensure;Environmental Exposure;Environmental Risk Factor;Evaluation;Extramural Activities;Functional disorder;Funding;Generations;Genetic;Genetic Models;Genetic Risk;genetic technology;genetic variant;Genetic Variation;Goals;High Fat Diet;Human;human disease;Image;imaging modality;imaging study;improved;Indiana;Infrastructure;innovation;insight;Institution;International;Intervention;Knowledge Portal;Laboratories;Late Onset Alzheimer Disease;Leadership;Mammalian Genetics;Measures;Medical;meetings;metabolomics;Mission;Modeling;Molecular;Monitor;mouse model;multidisciplinary;multiple omics;Mus;Mutation;Nerve Degeneration;neuroimaging;neuropathology;next generation;novel;novel therapeutics;Outcome Measure;Pathology;Peer Review;Pharmacodynamics;Pharmacologic Substance;Pharmacotherapy;Phenotype;potential biomarker;pre-clinical;Preclinical Testing;prevent;Process;Property;Proteomics;Protocols documentation;Publications;Recommendation;Research;Research Personnel;Resources;Risk;risk variant;Sampling;screening;Staging;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic evaluation;tool;transcriptomics;Translating;Translations;Treatment Efficacy;TREM2 gene;United States;Universities;Untranslated RNA;uptake;Variant;web-based tool;Work

PROJECT_TITLE: IU/JAX/PITT MODEL-AD Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LAMB, BRUCE T (contact)

PROJECT_TERMS: Acceleration;Accounting;Achievement;Administrator;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Area;Benchmarking;Bioinformatics;Biological Assay;Communication;Communities;cost;Data;data management;data standards;data structure;Dedications;Development;disease model;Ensure;Evaluation;Extramural Activities;Feedback;Fostering;Funding;Generations;Goals;Grant;Head;improved;Indiana;Joints;Laboratories;Late Onset Alzheimer Disease;Leadership;Measures;Medicine;meetings;member;Mission;model organism;Modeling;Monitor;neuroimaging;operation;Oral;Peer Review;Preclinical Testing;programs;Progress Reports;Publications;Recommendation;Reporting;Research;Research Personnel;Resources;Staging;success;synergism;therapy development;Time;timeline;United States National Institutes of Health;Universities;Update;uptake;wasting;Work;Writing

PROJECT_TITLE: Administrative and Coordination Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: CARTER, GREGORY W (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Automobile Driving;Bioinformatics;Biological;Biological Assay;Biological Markers;Biology;candidate marker;cell growth;cohort;Cohort Studies;Communities;Computer Analysis;Data;Data Analyses;data dissemination;data management;data modalities;data modeling;data reuse;Dimensions;Disease;Disease Pathway;empowerment;Environmental Risk Factor;European ancestry;FAIR principles;Foundations;Functional disorder;Funding;Genetic;Genetic Load;Genetic study;genetic variant;Genome;genome-wide;Goals;Human;human disease;human study;Image;Joints;Knowledge Portal;Late Onset Alzheimer Disease;machine learning method;Metadata;Methods;Modeling;Molecular;Monitor;mouse model;Mouse Strains;multimodality;Multiomic Data;multiple omics;Mus;open data;Outcome;Pathology;Pathway interactions;Population;Positioning Attribute;pre-clinical;Precision therapeutics;preclinical study;Preclinical Testing;Process;Protocols documentation;quality assurance;Research;Research Personnel;resilience;Resources;sharing platform;System;Therapeutic;therapeutic candidate;Therapeutic Uses;tool;Untranslated RNA;Variant;web platform

PROJECT_TITLE: Bioinformatics and Data Management Core


PI_NAMEs: TERRITO, PAUL RICHARD (contact)

PROJECT_TERMS: Aftercare;Age;Algorithms;Alzheimer's disease model;Behavior assessment;Behavioral;Biological Markers;Biological Products;biomarker performance;Blood;Brain;Cerebrospinal Fluid;Chronic;Clinic;Clinical;clinical candidate;clinical translation;Cognitive;Communities;Coupled;Data;design;Disease;disease model;Dose;Drug Kinetics;Drug Screening;Drug Side Effects;Drug Stability;drug testing;Effectiveness;efficacy evaluation;efficacy study;Electroencephalography;Evaluation;experimental study;Feedback;Formulation;functional outcomes;Funding;Goals;imaging biomarker;improved;in vivo;Infrastructure;insight;interest;Intervention;Knowledge Portal;Late Onset Alzheimer Disease;Liquid substance;Longitudinal Studies;Measures;metabolomics;Methodology;Methods;Molecular;Molecular Profiling;Monitor;mouse model;multiple omics;neurophysiology;novel marker;Outcome;Outcome Measure;Pathologic;PET/CT scan;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacologic Substance;Pharmacotherapy;Phase;Phenotype;Plasma;pre-clinical;Preclinical Testing;predictive modeling;Process;Property;Proteomics;Protocols documentation;quality assurance;Quality Control;Regimen;Research;Resources;response;screening;Selection Criteria;Sensitivity and Specificity;small molecule;specific biomarkers;Standardization;success;Symptoms;Testing;Therapeutic;therapeutic evaluation;Therapeutic Index;Therapeutic Intervention;tool;transcriptomics;translational therapeutics;Treatment Efficacy;web site

PROJECT_TITLE: Pre-Clinical Testing Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Nutrition;Prevention

PI_NAMEs: HOWELL, GARETH R (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Age Months;age related;aged;Alleles;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid imaging;Animal Model;apolipoprotein E-4;Biochemistry;Bioinformatics;Biological Assay;Biological Markers;Biological Models;Brain;Chronic;Clinic;Clinical Trials;Cognitive;cognitive testing;Communities;comparison control;Consumption;Coupled;CRISPR/Cas technology;Data;data management;design;Development;Diet;digital;disease model;disease phenotype;efficacy testing;Environmental Risk Factor;Evaluation;familial Alzheimer disease;Fatty acid glycerol esters;Female;Funding;Genetic;Genetic Risk;genetic risk factor;genetic variant;Genotype;Haplotypes;Heterogeneity;High Fat Diet;Hippocampus;Human;Image;improved;in vivo imaging;Late Onset Alzheimer Disease;Ligands;Liquid substance;Long-Term Potentiation;longitudinal design;Magnetic Resonance Imaging;male;MAPT gene;Medicine;metabolomics;model development;model organism;Modeling;mouse genetics;mouse model;multiple omics;Mus;Mutation;nano-string;neuroinflammation;neuron loss;neuropathology;novel;Pathology;PET/CT scan;Phenotype;Polygenic Traits;Positron-Emission Tomography;Pre-Clinical Model;preclinical efficacy;preclinical study;Preclinical Testing;Predictive Factor;Predisposition;Proteomics;Research;Risk;Risk Factors;risk variant;Scheme;screening;sugar;Synapses;synergism;tau aggregation;Testing;transcriptome;transcriptomics;Translating;Translations;TREM2 gene;United States Food and Drug Administration;Variant;Vertebral column;Work

PROJECT_TITLE: Disease Model Development and Phenotyping Project


ORG_CITY: Taylorsville

ORG_NAME: UTAH DEPARTMENT OF AGRICULTURE/FOOD

ORG_STATE: UT

PHR: URRT- Project Narrative- 2023-RFA-FD-23-019- Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Project Narrative The overarching goals of the Utah Rapid Response Team for this three-year project are to: Goal 1- Increase outreach,education, and training  a. Objective 1.1- participate in conference presentations  b. Objective 1.2- provide training opportunities  c. Objective 1.3- remain active through committee participation Goal 2- Coordinate outbreak response in human and animal food  a. Objective 1.1- maintain relationships with subject matter experts  b. Objective 1.2- refine and use the URRT activation criteria  c. Objective 1.3- continue to update the emergency response list Goal 3- Maintain a readiness status for emergency response  a. Objective 1.1- ensure all equipment is up to date and in good working order, including  supplies to run an Incident Command Post as needed  b. Objective 1.2- maintain proper equipment logs  c. Objective 1.3- open lines of communication with partners Goal 4- Continue long term sustainability through the Utah Rapid Response Steering Committee  a. Objective 1.1- continue monthly meetings  b. Objective 1.2- maintain steering committee members including epidemiology,  environmental health, laboratory, feed, local, state, federal, and tribal food safety experts  c. Objective 1.3- track in kind contributions to show the depth of membership involvement Goal 5- Continue to work with local, state, federal, and tribal partnerships to maintain and  improve food safety culture throughout the state of Utah  a. Objective 1.1- continue to sponsor an annual food safety conference  b. Objective 1.2- continue to be actively engaged with our state Emergency Operations Center  c. Objective 1.3- continue to support national RRT committees to improve food safety practices Goal 6- Keep our standards current and support the Manufacture Food Program, Produce, Local Health Departments, Animal Feed, and others  a. Objective 1.1- maintain Standard 3- Inspection Program (Recalls)  b. Objective 1.2- maintain Standard 5- Food-related Illness, Outbreaks and Emergency Response  c. Objective 1.3- maintain Standard 7- Industry and Community Relations

PI_NAMEs: WALLER, TRAVIS PINE (contact)

PROJECT_TITLE: Utah Rapid Response Team Level 2 Maintenance


ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPT/ HEALTH & SENIOR SRV

ORG_STATE: MO

PHR: Project Narrative-RRT Foodborne illness and food contamination emergencies are complex and can stretch across many jurisdictions and multiple states. The Missouri Department of Health and Senior Services (MDHSS) proposes to not only maintain its Rapid Response Team (RRT) for food and feed to respond to large emergencies, but also to move ahead with improvements from lessons learned along with new innovations and initiatives. The Missouri RRT will add to its outreach in collaboration with local jurisdictions and other states, test and continue to apply new ideas to improve response capabilities, prevention and integration of the food safety system.

PI_NAMEs: HUESTE, ERIC  (contact)

PROJECT_TITLE: Development and Maintenance of Human and Animal Food Rapid Response Teams


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

ORG_STATE: CO

PHR: Project Narrative Environmental health professionals are responsible for expertise in a variety of subject matter areas ranging from food safety and retail program standards to emergency preparedness and response and water quality. The AEC aims to provide the most relevant in-person education and the means to connect and engage with peers to build capacity for their organizations and meet the changing needs of the communities they serve. Each AEC highlights how local agencies, industries, and levels of government work to ensure the safety of the public and environment, and how they contribute to the advancement of the environmental health profession.

PI_NAMEs: DYJACK, DAVID T (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: AEC Conference Support 5 year


ORG_CITY: HARTFORD

ORG_NAME: CT STATE DEPT OF CONSUMER PROTECTION

ORG_STATE: CT

PHR: Narrative The State of Connecticut has achieved project milestones for the Connecticut RRT for the period of last grant. The purpose of this grant is to maintain progress in CT’s Rapid Response Teams (RRTs) to facilitate long-term improvements and innovation to the national Integrated Food Safety Aystem by unifying and coordinating federal/state/local human and animal food (HAF) emergency response efforts including: 1) Strengthening the link among epidemiology, lab and environmental health/regulatory components. 2) Improving States' regulatory and surveillance HAF protection programs to include using Incident Command System (ICS)/National Incident Management System (NIMS) principles and a Unified Command structure to conduct integrated responses to all-hazards HAF emergencies, rapidly identifying and removing tainted food from commerce, and conducting root cause investigations to inform future prevention efforts; and 3) Addressing supporting components, such as training, data sharing, data analysis, communications, continuous process improvement, and development of best practices and other resources to support national response capacity/capability development.

PI_NAMEs: GREENE, FRANK E (contact)

PROJECT_TITLE: Connecticut DCP RRT Maintenance


ORG_CITY: OLYMPIA

ORG_NAME: WA STATE DEPARTMENT OF AGRICULTURE

PHR: RFA-FD-23-019- Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Project Narrative This project intends to improve the nationally integrated human and animal food safety system through maintenance of the Rapid Response Team (RRT) for the Washington State Department of Agriculture (WSDA). The WSDA’s key performance areas will be strengthening the link among public health data and regulatory components, improving the state’s regulatory and surveillance human and animal food (HAF) protection programs to include the use of the Incident Command System (ICS), and developing best practices to support national response capacity.

PI_NAMEs: MINOR, DAVID UNITED STATES (contact)

PROJECT_TITLE: Maintenance of the Washington State Department of Agriculture (WSDA) Rapid Response Program


ORG_CITY: BALTIMORE

ORG_NAME: MARYLAND STATE DEPARTMENT OF HEALTH

ORG_STATE: MD

PHR: Flexible Funding Model-Development and Maintenance of Human and Animal Food  Rapid Response Teams  Funding Opportunity: RFA-FD-23-019 Project Period: July 1, 2023 - June 30, 2026 Budget Period: July 1, 2023 - June 30, 2024  CFDA Number: 93.103 Maintenance and Continuation of the State of Maryland Rapid Response Team Project Narrative The Maryland Department of Health, Prevention and Health Promotion Administration’s Office of Food Protection (the Department) seeks to maintain the State of Maryland Raid Response Team (SMarRRT) program. The purpose of the program is to continue to provide a multiagency, multidisciplinary team to manage and respond to intrastate and interstate food emergencies that impact Maryland. Since its inception in 2012, the team has managed and responded to many food related emergencies, creating standardized procedures to facilitate communication and increase efficiencies in responses and public health outcomes.

PI_NAMEs: MITCHELL, CLIFFORD S (contact)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rural Health;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE The increased use and misuse of opioids during pregnancy and resulting Neonatal Opioid Withdrawal Syndrome (NOWS) are critical public health concerns in the United States. We will collaborate as a member of the proposed research group to design and conduct a multicenter clinical trial to directly compare the effectiveness of pharmacologic treatments for infants with NOWS. We anticipate that our studies will identify the optimal treatment for NOWS to improve the care and overall health and neurodevelopmental outcomes of infants with NOWS throughout the US.

PI_NAMEs: DEVLIN-PHINNEY, LORI ANN (contact);TELANG, SUCHETA

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accounting;Address;Adjuvant Analgesic;Affect;behavioral outcome;care outcomes;Caring;Child;Childhood;Clinic;Clinical;clinical care;Clinical Nursing Research;Clinical Pharmacology;clinical practice;Clinical Practice Guideline;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;Communities;community advisory board;community partners;comparative effectiveness trial;compare effectiveness;Confounding Factors (Epidemiology);Country;Data Analyses;data sharing;Dedications;design;Development;Dose;effective therapy;Enrollment;Ensure;Evaluation;evidence base;experience;Family;Female of child bearing age;Fetal Development;follow-up;Frequencies;Geography;Goals;Health;Health Personnel;Healthcare Systems;high risk;Hospitalization;Hospitals;improved;improved outcome;Infant;Infant Care;infant outcome;Infrastructure;Kentucky;Leadership;Length of Stay;Life;Medical;Medical Care Team;member;Mothers;Multi-Institutional Clinical Trial;Multi-site clinical study;Neonatal;Neonatal Abstinence Syndrome;Neonatal Intensive Care Units;neonate;Newborn Infant;Opioid;opioid epidemic;opioid misuse;opioid use;opioid use in pregnancy;optimal treatments;Outcome;outreach;Patient Recruitments;Patients;pediatric department;pediatrician;pharmacologic;Pharmacological Treatment;Play;Population;Population Heterogeneity;Pregnancy;prenatal exposure;Prevalence;programs;prospective;Psychotropic Drugs;Public Health;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Design;Research Personnel;Role;Rural;rural area;rural underserved;Sample Size;Scientist;Site;Solid;standard of care;Standardization;Stress;suburb;Treatment Protocols;underserved area;United States;United States National Institutes of Health;Universities;urban underserved;Variant;Visit;Withdrawal;Work

PROJECT_TITLE: Neonatal Opioid Withdrawal Syndrome (NOWS) in Kentucky: Improving Outcomes for Infants


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Melanoma is the most serious type of skin cancer with a low survival rate at advanced stages. Here, we propose 1) developing a melanoma peptide vaccine delivery system for effective antitumor immunomodulation, and 2) testing such delivered vaccines to elicit potent, broad, and long-lasting immune responses to promote the efficacy of melanoma combination immunotherapy. The results may improve the clinical practice and outcomes of melanoma treatment. 1

PI_NAMEs: ZHU, GUIZHI  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Address;Adjuvant;Agonist;Albumins;anti-cancer;anti-tumor immune response;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Benchmarking;Binding;biomaterial compatibility;CD4 Positive T Lymphocytes;CD8B1 gene;Chemicals;Chemistry;Clinical;clinical practice;clinical translation;Combination immunotherapy;Combined Modality Therapy;Data;DNA;DNA Binding;Engineering;Evans blue stain;Future;Genetically Engineered Mouse;Goals;Immune;immune cell checkpoints;immune checkpoint;immune checkpoint blockade;Immune response;Immune Tolerance;Immunity;immunogenic;immunogenicity;Immunologic Adjuvants;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;incomplete Freund's adjuvant;Innate Immune Response;innovation;Ligands;Location;lymph nodes;Lymphocyte;Major Histocompatibility Complex;Maleimides;manufacture;Measures;Melanoma;Melanoma patient;Melanoma Vaccine;Metastatic Melanoma;Modeling;Molecular Vaccines;mouse model;Mus;nano;nanovaccine;neoantigens;Neoplasm Metastasis;Outcome;Pathway interactions;Patients;Peptide Vaccines;Peptides;Pharmacologic Substance;pre-clinical;Productivity;research clinical testing;response;scaffold;Site;Skin Cancer;Stromal Cells;Structure;success;Survival Rate;synergism;System;T cell response;Testing;Therapeutic;Toll-like receptors;Toxicology;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;tumor heterogeneity;tumor microenvironment;Vaccine Antigen;vaccine delivery;vaccine evaluation;vaccine formulation;vaccine platform;vaccine safety;vaccine trial;Vaccines;Work

PROJECT_TITLE: Lymph Node-Targeted Codelivery of Albumin-Binding Peptide Antigens and Di-Adjuvant for Melanoma Combination Immunotherapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Services;Lung;Neonatal Respiratory Distress;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

PHR: PROJECT NARRATIVE A proposal to participate in a collaborative consortium of clinical centers to conduct a multicenter randomized controlled pharmacologic comparative effectiveness trial in neonates experiencing neonatal opioid withdrawal syndrome unable of being managed by nonpharmacological methods.

PI_NAMEs: SOKOL, GREGORY M. (contact)

PROJECT_TERMS: Academic Medical Centers;Accounting;Admission activity;Age;Area;arm;Basic Science;Behavior;biomedical referral center;Birth;Buprenorphine;Caregivers;Caring;Child;Childhood;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Research Protocols;Clinical Services;Clinical Trials;Collaborations;comparative effectiveness;comparative effectiveness trial;Conduct Clinical Trials;Critical Illness;Data;design;Development;Diagnosis;Dose;effectiveness clinical trial;Eligibility Determination;Enrollment;Environment;Evaluation;experience;Faculty;falls;Familiarity;follow-up;Follow-Up Studies;Genomics;Health;high risk;hospital care;Hospitals;improved;Indiana;Individual;Infant;Infant Care;inhaled nitric oxide;inner city;innovation;Investigation;Knowledge;Leadership;Length of Stay;Link;Measures;Medical Research;medical schools;Methadone;Methodist Church;Methods;Morphine;Mothers;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal Abstinence Syndrome;neonatal care;neonatal respiration;neonate;Newborn Infant;Nonpharmacologic Therapy;novel;opioid epidemic;Outpatients;patient population;Patients;Pediatric Hospitals;Pediatric Research;Perinatal;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Population;Pregnant Women;prevent;Principal Investigator;programs;Proteomics;Protocols documentation;Pulmonary Hypertension;Randomized;Randomized, Controlled Trials;reduce symptoms;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;research study;Respiratory Failure;Role;Satiation;Schedule;Scientific Inquiry;Screening procedure;service delivery;Standardization;standardized care;stem cell biology;Symptoms;Time;Translational Research;treatment strategy;Universities;Urban Hospitals;Weaning;Withdrawal;Withdrawal Symptom;Woman

PROJECT_TITLE: Incorporating nonpharmacologic approaches into a comparative effectiveness pharmacologic trial for neonates with neonatal opioid withdrawal syndrome (NOWS)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Lymphatic Research;Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Neurodevelopmental disorders such as Fragile X Syndrome (FXS) represent a devastating array of diseases sharing common feature, notably social dysfunction. Using a mouse model of FXS, our goal is to demonstrate how the meningeal lymphatic system is dysfunctional in FXS and contributes to alteration of neuronal circuitry and social behavior. Successful completion of this proposal will enhance our understanding of the pathophysiology of FXS (and potential other neurodevelopmental diseases) and offer new therapeutic avenues targeting the meningeal lymphatic system to restore behavioral impairment.

PI_NAMEs: LOUVEAU, ANTOINE  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;adherent junction;Adult;Attention Deficit Disorder;autism spectrum disorder;Behavior;Behavioral;behavioral impairment;Brain;brain parenchyma;Calcium;Cell Maintenance;Cells;Cerebrospinal Fluid;Circulation;cognitive function;Cytoskeletal Proteins;Data;Development;Disease;Drainage procedure;Excision;FMR1 gene;Fragile X Syndrome;Functional disorder;Gene Expression;Genes;Goals;Health;Homeostasis;Image;Immune;improved;Interferon Type II;Knowledge;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;Lymphocyte;Maintenance;Menin;Meningeal;Meningeal lymphatic system;Meninges;Modeling;Molecular;molecular targeted therapies;Morphology;mouse model;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuroinflammation;neuronal circuitry;Neurons;new therapeutic target;novel therapeutics;old mice;Pathway interactions;Pattern;Population;postnatal;Prefrontal Cortex;Production;Proliferating;Properdin;protein expression;Proteins;Proteomics;Regulation;Role;Scheme;Signal Transduction;social;Social Behavior;social deficits;Symptoms;System;T cell regulation;T-Lymphocyte;Testing;Therapeutic;Tight Junctions;transcriptomic profiling;transcriptomics;Vascular Endothelial Growth Factor C;Viral;wasting;Width

PROJECT_TITLE: Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Reactive oxygen species (ROS) play pivotal roles in both signaling and stress, but their transient nature makes them challenging to study in living systems. Traditionally, small-molecule fluorescent probes are used to detect and visualize ROS through fluorescence imaging; however, these probes diffuse after ROS detection leading to inaccurate measurements of ROS localization and poor signal-to-noise responses. This proposal aims to develop cell-trappable tandem activity- based-sensing and labeling fluorescent probes as a platform study redox homeostasis in biological systems.

PI_NAMEs: MESSINA, MARCO  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Alzheimer's Disease;Biological;Biological Models;biological systems;Cardiovascular Diseases;Cell Communication;Cell Death;Cell Line;Cells;cellular imaging;cellular targeting;Chemicals;Coculture Techniques;Collaborations;Complex;Coupled;Data;design;Detection;Diffuse;Diffusion;Disease;Ethers;experience;Exposure to;Family;fluorescence imaging;Fluorescence Microscopy;Fluorescent Probes;fluorophore;Foundations;Goals;Homeostasis;Hydrogen Peroxide;Hypochlorous Acid;Image;imaging platform;In Vitro;Label;Malignant Neoplasms;Maps;Measurement;Mediating;Metabolic;Microglia;Modeling;Molecular Probes;Monitor;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Noise;Organism;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathology;Phase;Phenols;Play;Polymer Chemistry;polymerization;Polymers;Process;Production;programs;Property;Proteins;quinone methide;Reaction;Reactive Oxygen Species;Research;response;Role;Sampling;Signal Transduction;Signaling Molecule;small molecule;Source;Stress;Superoxides;Surface;System;Testing;Tissues;tool;Training;Visualization

PROJECT_TITLE: An Activity-Based Biomolecule Labeling Platform for the Imaging of Cells and Tissues Under Oxidative Stress

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Although most of the 23% of incarcerated people in South Africa who are also living with HIV initiate antiretroviral therapy (ART) during incarceration, only one third remain on ART following release. We pilot tested an intervention that succeeded in retaining 61% of individuals in care compared to 36% with usual services: Structured Peer-delivered ART and Reentry Strategy (SPARCS). We are seeking to conduct a randomized control trial that addresses the tension between effectiveness and scalability by: (1) testing each of the SPARCS components independently in a randomized controlled trial with a 2x2 factorial design trial to maximize statistical power, (2) identifying key elements of implementation including reach, adoption, adaptations, and fidelity, and (3) provide cost and cost-effectiveness results to guide scale-up decisions.

PI_NAMEs: HOFFMANN, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Address;Adjusted Life Years;Adopted;Adoption;Adult;Age;age group;antiretroviral therapy;Behavioral;Caring;Cause of Death;Clinic;Collaborations;Communities;community clinic;community reentry;comparative cost effectiveness;Continuity of Patient Care;cost;cost comparison;cost effectiveness;design;disparity reduction;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation study;Elements;Environment;epidemic response;Equilibrium;Failure;financial literacy;Future;General Population;Goals;Government;Group Structure;Health;Health system;high risk;HIV;Hybrids;implementation cost;implementation determinants;implementation fidelity;implementation strategy;Imprisonment;improved;improved outcome;Individual;interest;Intervention;Intervention Studies;Interview;Knowledge;Life;Maintenance;Manuals;Measures;member;Methods;Modification;National Institute of Mental Health;Outcome;Output;Participant;peer;Persons;Pilot Projects;pilot test;Policy Maker;Population;Prevalence;primary outcome;Problem Solving;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Role;Sampling;scale up;Schedule;Self Efficacy;Services;sex;skills;Social support;societal costs;South Africa;South African;statistics;Structure;substance use;Techniques;Testing;treatment arm;treatment as usual;Treatment Failure;trial design;trial enrollment;United States National Institutes of Health;usual care arm;Viral Load result;Work

PROJECT_TITLE: Structured Peer-delivered ART and Reentry Community Strategy (SPARCS) to overcome barriers to HIV care continuity during community reentry from incarceration in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Primary Health Care;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative In this study, we will develop a comprehensive mHealth-community health worker (CHW) tool for cesarean section (c-section) follow-up that is usable and acceptable to CHWs in rural Rwanda. We will then assess the validity of this tool during a prospective pilot, the impact of this tool on time-to-diagnosis in a randomized trial, as well as the acceptability of the tool to mothers delivering via c-section. This research will support the ability of CHWs to provide safe, accessible, and affordable in-home c-section follow-up care to women in rural Africa, thus decreasing the physical and financial burden of facility-based follow-up for new mothers.

PI_NAMEs: HEDT-GAUTHIER, BETHANY  (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Africa;Africa South of the Sahara;Algorithmic Software;Algorithms;arm;care seeking;Caring;Cells;Cellular Phone;Cesarean section;Clinical;Collaborations;Community Health Aides;Complication;Computer software;cost;cost estimate;Country;design;Development;Diagnosis;diagnostic algorithm;diagnostic tool;Ensure;experience;Face;Failure;Feedback;Financial Hardship;Focus Groups;follow-up;Future;Goals;Grant;Health;Health care facility;Health system;Home;Home visitation;Hospitals;Image;implementation fidelity;Internet;Intervention;Lead;Libraries;Machine Learning;Maternal Mortality;Methods;mHealth;Monitor;Morbidity - disease rate;mortality;Mothers;novel;Phase;Physical Examination;Population;postcesarean section;Postoperative Period;postpartum care;Postpartum Period;primary outcome;programs;prospective;Qualitative Methods;Randomized;randomized trial;Recovery;Reporting;Research;Research Training;Risk;Running;Rural;Rwanda;Sampling;Series;standard of care;support tools;Surgical Wound Infection;Surveys;Technology;Telephone;Testing;Time;tool;Training;Travel;usability;Vagina;Woman;Work

PROJECT_TITLE: mHealth-Community Health Worker tool for comprehensive post-cesarean follow-up in rural Rwanda


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Narrative The widespread adoption of Electronic Health Records (EHRs) has enabled secondary use of EHR data for clinical and translational research. We propose to advance informatics solutions to enable cohort discovery using information retrieval and deep representation techniques.

PI_NAMEs: HERSH, WILLIAM R;LIU, HONGFANG  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Acceleration;Adopted;Adoption;Algorithms;Architecture;Clinic;Clinical;Clinical Data;clinical data warehouse;Clinical Research;clinical research site;clinical trial recruitment;Clinical Trials;cohort;Cohort Studies;Collection;Communities;Complex;COVID-19;Data;data modeling;data standards;density;design;Development;Electronic Health Record;Eligibility Determination;Evaluation;experimental study;Feedback;Formulation;Goals;health care delivery;Healthcare;Healthcare Systems;heterogenous data;Human;indexing;Informatics;Information Retrieval;innovation;Institution;Language;Learning;learning strategy;Medical;Methods;Modeling;Morphologic artifacts;Natural Language Processing;neural;novel;open source;Outcome;Patient Recruitments;Patients;Performance;Pharmaceutical Preparations;portability;predictive modeling;Process;query tools;recruit;Research;Resources;Retrieval;search engine;Semantics;Site;Structure;structured data;System;Techniques;Text;Time;tool;Training;Translational Research;Visit;Work

PROJECT_TITLE: Semi-structured Information Retrieval in Clinical Text for Cohort Identification

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Profound disparities in birth outcomes persist in the United States at a huge cost to individuals and society. Nevertheless, the root social environmental determinants of poor birth outcomes remain elusive, particularly for immigrant populations. By using data science, spatial techniques, and qualitative methods to examine the experiences of immigrant women, the proposed research will advance understanding of the pathways between contextual social factors and pregnancy and birth outcomes.

PI_NAMEs: SAMARI, GOLEEN  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: 37 weeks gestation;Address;Adolescence;Adult;adverse birth outcomes;Affect;Area;Attention;Attitude;base;Behavior Therapy;Big Data;Birth;Buffers;career;Cessation of life;Child;child bearing;Child Health;Childhood;Consensus;cost;Country;COVID-19;Data;Data Science;Demography;Destinations;Development;Disparity;Educational Intervention;Environment;Ethnic Origin;experience;Family;fetal;Generations;Growth;Health;health disparity;Health system;Heterogeneity;Home;Immigrant;Immigration;improved;Individual;infancy;Infant;Infant Mortality;innovation;insight;Internet;Knowledge;Length of Stay;Life;Life Cycle Stages;Link;Lived experience;Low Birth Weight Infant;Maternal and Child Health;Maternal Health;Maternal-fetal medicine;Measures;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;migration;Migration Policy;Not Hispanic or Latino;Olives - dietary;Outcome;Pathway interactions;Perinatal;Perinatal Epidemiology;perinatal health;Personal Satisfaction;Policies;policy implication;Politics;Population;Pregnancy;Premature Birth;Prenatal care;Process;Qualitative Methods;Race;reproductive;Reproductive Health;Research;Research Personnel;response;Risk;Risk Factors;Role;Shapes;skills;Small for Gestational Age Infant;social;social disparities;Social Environment;social factors;social stigma;Societies;Socioeconomic Status;Stress;stressor;structural determinants;structural health determinants;Surveys;System;Techniques;Testing;Training;United States;United States National Center for Health Statistics;Variant;White Women;Woman

PROJECT_TITLE: Migration, Dynamic Social Environments, and Birth Outcomes

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Clinical Research;Contraception/Reproduction;Estrogen;Lead Poisoning;Nutrition;Osteoporosis;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Depot medroxyprogesterone acetate (DMPA) is an important contraceptive option for the prevention of unintended pregnancy for millions of women globally. However, the well-established side effect of increased bone turnover and bone loss with DMPA use may mobilize toxic metal lead stored in bone to plasma, exposing DMPA users to increased circulating lead levels. Given that chronic exposure to lead from water, air, food, and dust is common, no safe levels of circulating lead exist, and strong evidence that lead negatively affects health, the information gleaned from the proposed project will inform the provision of safer contraception in adolescent, adult, and lactating women.

PI_NAMEs: UPSON, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: 25-hydroxyvitamin D;Adherence;Adolescent;adolescent woman;Adult;Affect;Age;Air;biological specimen archives;Black Box;Body System;bone;Bone Density;bone imaging;bone loss;Bone remodeling;bone turnover;calcium intake;Calcium ion;Cardiovascular Diseases;Cessation of life;Child;Chronic Kidney Failure;chronic Pb exposure;cigarette smoke;Circulation;cognitive function;Communities;condoms;contaminated water;Contraceptive Agents;Contraceptive methods;Cross-Sectional Studies;Cyclophosphamide;Data;dietary;Dietary Calcium;Dose;Dual-Energy X-Ray Absorptiometry;Dust;Estrogens;follow-up;Food;Funding;Glean;Goals;Half-Life;Health;hip bone;HIV;hormonal contraception;Human;Hypertension;indexing;Ingestion;Inhalation;Injectable;Injections;Investments;Lactation;Lead;lead acetate;lead exposure;Lead levels;Location;Longitudinal Studies;Measurement;Measures;Medroxyprogesterone 17-Acetate;Modeling;Monitor;National Institute of Child Health and Human Development;novel;Oral;Organ;Ovarian;Participant;Plasma;pre-exposure prophylaxis;Predisposition;pregnancy prevention;Prevention;Production;prospective;Prospective Studies;Reporting;Research;Serum;side effect;skeletal;Source;substantia spongiosa;Tenofovir;Testing;Time;Toxic effect;toxic metal;Trabecular Bone Score;Uganda;unintended pregnancy;urinary;Urine;Vertebral column;Visit;Vitamin D;Water;Woman;young woman

PROJECT_TITLE: Contraceptive DMPA-induced bone loss: A novel source of toxic metal lead exposure in young women

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Lay Summary This project aims to spearhead the role of imaging in the personalized management of early-stage lung cancer treated with neoadjuvant immunotherapy. The proposed studies will lead to the development of computational tools to extract quantitative imaging biomarkers from serial PET and CT scans and to the evaluation of the biological and clinical relevance of these imaging biomarkers. The new imaging biomarkers will close the unmet clinical need in immunotherapy for early-stage lung cancer by identifying those patients most likely to benefit from treatment, maximizing the clinical effectiveness of immunotherapies, and thus promoting a major paradigm shift of the role of radiographic imaging to serve as an important approach in precision cancer management.

PI_NAMEs: CASCONE, TINA ;WU, JIA  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Adjuvant;Adjuvant Study;Adjuvant Therapy;Algorithms;Biological;Biological Markers;biomarker validation;Cancer Etiology;cancer immunobiology;Characteristics;Clinical;Clinical effectiveness;clinical efficacy;clinical investigation;clinical practice;clinical predictors;Clinical Trials;clinically relevant;cohort;comparative efficacy;computational pipelines;computerized tools;Control Groups;Curative Surgery;Data;Data Science;Data Set;design;Development;Disease;Disease Progression;disorder risk;efficacy evaluation;Evaluation;Evolution;fluorodeoxyglucose positron emission tomography;Goals;Habitats;Image;imaging biomarker;Immune;Immune checkpoint inhibitor;Immuno-Chemotherapy;Immunocompetent;Immunogenomics;Immunologic Memory;Immunologics;Immunotherapy;immunotherapy trials;improved outcome;Knowledge;Lead;Lung;Lymph Node Involvement;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Meta-Analysis;Metastatic Neoplasm to the Lung;Micrometastasis;Modeling;molecular marker;mortality;mouse model;multiple omics;Mus;Neoadjuvant Study;Neoadjuvant Therapy;Neoplasm Metastasis;Nodal;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathologic;Patient Care;patient stratification;Patients;Performance;peripheral blood;personalized management;PET/CT scan;Phase;phase 2 study;Phenotype;Physiological;Positioning Attribute;Positron-Emission Tomography;Postoperative Period;pre-clinical;Pre-Clinical Model;predictive modeling;prevent;Primary Neoplasm;quantitative imaging;Radio;Radiogenomics;radiological imaging;radiomics;Randomized;randomized trial;Recurrent tumor;Reporting;research clinical testing;Resectable;response;Risk;Role;serial imaging;Spatial Distribution;standard of care;Structure of parenchyma of lung;Surrogate Endpoint;survival outcome;Testing;Thoracic Oncology;Tissues;Toxic effect;Training;Translating;Treatment Efficacy;treatment response;treatment stratification;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Tumor-infiltrating immune cells;United States;Unresectable;X-Ray Computed Tomography

PROJECT_TITLE: Radioimmunogenomic Habitat Phenotypes to Predict Efficacy of Neoadjuvant Immunotherapies in Non-Small Cell Lung Cancer


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The Neonatal Opioid Withdrawal Syndrome (NOWS) Treatment Trial will assess the optimal pharmacological treatment for NOWS through a multicenter, comparative effectiveness trial of three commonly used medications. The CHOP/Penn Neonatal Clinical Trials Network team will contribute expertise in clinical trial methodology, substance abuse, and neonatal follow-up, providing rigorous scientific input into design and implementation of the multicenter NOWS Treatment Trial. We will then execute all aspects of the trial to the highest standard, including robust participant recruitment, rigorous adherence to all aspects of the study protocol, and neurodevelopmental follow-up to two years with minimal attrition.

PI_NAMEs: DEMAURO, SARA BONAMO;LORCH, SCOTT A (contact)

PROJECT_TERMS: Adherence;adverse outcome;American;Birth;Caring;Child Welfare;Clinic;clinical epidemiology;clinical infrastructure;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;comparative effectiveness trial;Country;Data;Dedications;design;Diagnosis;Eating;Emergency department visit;Ensure;Environment;experience;Exposure to;follow-up;Funding;Grant;healing;Health Expenditures;high risk;high standard;Hospitals;Incidence;Infant;Infant Care;infant outcome;Intensive Care;Lead;Length;Length of Stay;Longitudinal Studies;meetings;member;Methadone;Methodology;Morphine;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;Newborn Infant;Nurseries;Opioid;opioid exposure;Outcome;Participant;patient population;Patient Recruitments;Pediatric Hospitals;Pennsylvania;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Pharmacotherapy;Phase;Philadelphia;Preventive service;Procedures;Protocols documentation;Public Health;randomized trial;readmission rates;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Site;Sleep;Substance abuse problem;success;System;Training;treatment trial;trial comparing;Universities;US State;Variant;Withdrawal;Work

PROJECT_TITLE: Neonatal Treatment Trial


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Services;Lung;Neonatal Respiratory Distress;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE A large, multicenter comparative effectiveness trial is needed to assess the optimal pharmacological treatment for neonatal opioid withdrawal syndrome (NOWS). Cincinnati Children’s Hospital Medical Center has a large population of infants with NOWS and the faculty expertise necessary to develop and perform such a trial.

PI_NAMEs: MERHAR, STEPHANIE L (contact)

PROJECT_TERMS: 2 year old;Age;behavioral outcome;Biological Markers;Brain;Buprenorphine;buprenorphine treatment;Child Development;Clinic;clinical care;Clinical Pharmacology;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Services;Clinical Trials;Collaborations;comparative effectiveness;comparative effectiveness trial;Data;design;Development;Drug Kinetics;Eating;Effectiveness;Enrollment;Epidemic;experience;Exposure to;Faculty;fetal opioid exposure;follow-up;Future;Helping to End Addiction Long-term;Hospitalists;improved;Infant;Infant Development;infant outcome;innovation;Inpatients;Kentucky;Length;Length of Stay;Live Birth;Medical center;member;Methadone;methadone treatment;Morphine;Multicenter Neonatal Research Network;Neonatal;Neonatal Abstinence Syndrome;neuroimaging;Newborn Infant;Ohio;Opioid;opioid exposure;opioid overdose;optimal treatments;Outcome;Outpatients;overdose death;Pediatric Hospitals;Perinatal;personalized medicine;Pharmaceutical Preparations;Pharmacodynamics;Pharmacological Treatment;Pharmacology;phase 1 study;Physician Executives;Population;population based;prenatal;Productivity;programs;Protocols documentation;Randomized;recruit;Research;Research Personnel;response;Services;Site;Sleep;Standardization;Structure;Treatment Protocols

PROJECT_TITLE: HEAL initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial: Cincinnati site


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  The application of modeling, computation, and experimental approaches for technology development is in high demand in both industry and academic Biophotonics research and development with an estimated economic impact of $90 billion annually. Our proposed program is designed principally for graduate student, post-doctoral, and early-career faculty researchers eager to advance their technical proficiency in Multiscale Biophotonics and access mentoring support for professional development to establish a successful career in support of the Biomedical workforce. The combination of our onsite 12-day intensive short course in combination with a subsequent year-long capstone problem-based learning module and sustained technical and professional mentorship collectively provides an evidence-based approach by which trainees will acquire both technical proficiency and confidence to pursue a successful biomedical careers in this important area.

PI_NAMEs: CHOI, BERNARD ;VENUGOPALAN, VASAN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Academia;Active Learning;Address;Applications Grants;Area;Articulation;Automobile Driving;Biological Sciences;Biomedical Research;biomedical scientist;Biomedical Technology;Biophotonics;Biophysics;Biotechnology;California;career;Career Choice;career development;Case Study;Code;Color;Comprehension;Computer Analysis;Computer software;course module;Custom;data acquisition;design;Development;Development Plans;early-career faculty;economic impact;Engineering;evidence base;experience;experimental study;Faculty;faculty research;Feedback;Fellowship;Fostering;Foundations;Frequencies;Geographic Locations;Goals;graduate student;Growth;Image;Individual;Industrialization;Industry;innovation;instrument;instrumentation;Journals;Laboratories;laboratory module;Leadership;Learning;Learning Module;learning outcome;lectures;Measurement;Measures;Medical Device;meetings;Mentors;Mentorship;metacognition;Microscopy;Modeling;Monitor;multidisciplinary;National Institute of General Medical Sciences;open source;outreach;Performance;Phototherapy;point-of-care diagnostics;Postdoctoral Fellow;Problem-Based Learning;Procedures;programs;project-based learning;Publications;Questionnaires;Research;research and development;Research Personnel;Research Training;Schedule;Science;Scientist;simulation software;Site;skill acquisition;skills;Students;Surveys;symposium;Technology;technology development;Thinking;Time;Tissues;tool;Training;United States National Institutes of Health;Universities;virtual;Workforce Development

PROJECT_TITLE: Multiscale Biophotonics: A Platform for Interdisciplinary Biomedical Research Training and Career Development


ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Proper control over the cell cycle is essential to development, homeostasis, and regeneration. The regulation of differentiation and the specification of cell fates has been extensively studied, as have the fundamental mechanisms of cell cycle control, but ubiquitous correlations observed between cell fate and the cell cycle have not been studied in detail. To understand how cell fate regulates the duration of the cell cycle and how changes in the duration of the cell cycle influence cell fate, we will employ a combination of cell lineage tracing, spatial transcriptomics, and an evolutionary approach to studying the structure of developmental lineages.

PI_NAMEs: SHAH, PAVAK KIRIT (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3-Dimensional;Animals;Atlases;Biological Models;Caenorhabditis elegans;Cell Culture Techniques;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Fate Control;cell fate specification;Cell Lineage;cell transformation;Cells;Collaborations;deep learning;Dependence;design;Development;Developmental Process;Disease;Embryo;Evolution;Exhibits;gene network;Gene Transfer Techniques;Genetic;Homeostasis;Human;Image;In Vitro;Individual;insight;Label;Link;Malignant Neoplasms;Microscopy;Modeling;Molecular;Molecular Analysis;mutant;Natural regeneration;Nematoda;novel strategies;Pattern;programs;reconstruction;Recording of previous events;Regulation;Resources;Same-sex;Somatic Cell;stem cells;Stereotyping;Structure;Study models;Techniques;Technology;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Lineage-Specific Mechanisms of Cell Cycle Timing Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  Current drugs used to treat Alzheimer’s disease ameliorate the symptoms of the disease but do not slow or reverse disease progression. We propose to discover small molecules that selectively activate PLC-2 to reproduce the highly robust neuroprotective effects of PLC-2 (P522R). These compounds will be unique tools to dissect the roles of PLC-2 in neuroprotection and serve as the initial leads for further work to develop novel therapeutics to treat Alzheimer’s disease.

PI_NAMEs: PEARCE, KENNETH HUGH;SONDEK, JOHN E;ZHANG, QISHENG  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Affinity;Allosteric Regulation;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;Antibodies;apolipoprotein E-4;Area;Biochemical;Biochemistry;Biological;Biological Assay;Biological Markers;Biophysics;Brain;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chemicals;cheminformatics;Classification;Clinical Research;Collection;Computing Methodologies;Coupled;CSF1R gene;Data;Development;Disease;Disease Progression;Docking;Drug Design;drug development;drug discovery;Drug usage;drug-like compound;Endocytosis;Failure;Fluorogenic Substrate;Follow-Up Studies;Future;Genes;Genetic;genetic association;genetic variant;genome wide association study;genome-wide analysis;Goals;high throughput screening;Human;Hydrolysis;Immune response;Impaired cognition;Individual;Informatics;Interleukins;invention;Isoenzymes;Late Onset Alzheimer Disease;Lead;Length;Libraries;Ligands;Link;Lipid Binding;Membrane;Microglia;mild cognitive impairment;Modeling;molecular dynamics;Mutation;Nervous System Disorder;neuroinflammation;neuroprotection;new therapeutic target;novel;novel therapeutics;Pathologic;Patients;Persons;Phagocytes;Phagocytosis;Pharmaceutical Chemistry;pharmacologic;Phenocopy;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase;Phospholipase C;Phosphorylation;PLCG2 gene;PLCgamma2;Population;Process;Property;receptor;recruit;reduce symptoms;Regulation;Reproducibility;Research;Resolution;response;Risk Reduction;Role;screening;side effect;Site;small molecule;small molecule therapeutics;Structural Models;Structure;success;tau-1;Testing;tool;TREM2 gene;Variant;Work

PROJECT_TITLE: Discovery of allosteric activators of phospholipase C-gamma2 to treat Alzheimer's disease

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Palliative Care;Telehealth

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative (Relevance) Bereavement support is a public health priority and integral to comprehensive palliative care, yet accessible, evidence-based interventions remain limited, particularly for bereaved parents. The loss of a child is arguably one of the most devastating experiences one can endure, leaving bereaved parents at risk for a number of detrimental mental and physical health outcomes and significantly reduced quality of life. The proposed multisite, mixed methods randomized controlled trial aims to improve continuity and accessibility of care through evaluation of a promising, conceptually sound, telehealth-delivered grief intervention – Meaning-Centered Grief Therapy – which has the potential to reduce the measurable burden of suffering for bereaved populations.

PI_NAMEs: LICHTENTHAL, WENDY G. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Anxiety;arm;barrier to care;Bereavement;Blinded;Cancer Patient;Caregivers;Caring;Cessation of life;Child;Communities;community setting;comparative efficacy;Complement;COVID-19;Data;depressive symptoms;design;Diagnostic;Dissemination and Implementation;Distress;Emotional;Evaluation;evidence base;Evidence based intervention;experience;Face;Fathers;Feeling hopeless;fighting;Goals;Grief reaction;Health behavior;Health Services Accessibility;Healthcare;Heart Diseases;high risk;Home;improved;innovation;Institution;Intervention;intervention effect;Intervention Studies;Interview;Left;Life;Malignant Neoplasms;Manuals;Measurable;Measures;Mediating;Mediator;Mental Depression;Mental Health;Methods;Mothers;neglect;novel;Outcome;Outcome Study;Pain;Palliative Care;Parents;Patient Self-Report;physical conditioning;Population;post intervention;primary outcome;Productivity;Psychotherapy;public health priorities;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;response;Risk;Role;Sampling;secondary outcome;Services;Site;sound;Structure;Symptoms;telehealth;Therapeutic;therapy development;Time;treatment arm;treatment as usual;treatment effect;Treatment Efficacy;trial comparing;Underserved Population;Videoconferencing;Work

PROJECT_TITLE: Meaning-Centered Grief Therapy for Parents Bereaved by Cancer: A Multisite Randomized Controlled Trial

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Thomas Jefferson University Hospital and Nemours at Jefferson have a long collaboration in improving the health of infants with maternal exposure to opioids. We propose to serve as clinical research site for the study “HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial - Clinical Sites” RFA-HD-21-031.

PI_NAMEs: ADENIYI-JONES, SUSAN ;KRAFT, WALTER K (contact)

PROJECT_TERMS: addiction;Affect;Agreement;assay development;Behavior;Biological Assay;Birth;Blood Volume;Buprenorphine;Caring;Catchment Area;Censuses;Childhood;Clinic;Clinical;Clinical Pharmacology;Clinical Psychology;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;comparative;comparative effectiveness;comparative effectiveness trial;Conduct Clinical Trials;Consensus;Consent;Continuity of Patient Care;Data;Data Analyses;Dedications;design;Dose;Drug Formulations;Drug Kinetics;Drug Stability;Education;effectiveness clinical trial;Elements;Enrollment;Ethics;experience;Experimental Psychology;Exposure to;Faculty;Family;feeding;Floor;follow-up;Funding;Funding Agency;Genetic;Geography;Health;Health system;Helping to End Addiction Long-term;Hospitals;improved;in utero;Incidence;Individual;Infant;Infant Health;Infrastructure;innovation;Institutional Review Boards;instrument;International;Intervention;Investigation;investigator-initiated trial;Journals;large datasets;Leadership;Link;Maternal Exposure;Measures;member;Modeling;Monitor;Morphine;Mothers;Multi-Institutional Clinical Trial;National Institute of Drug Abuse;Neonatal;Neonatal Abstinence Syndrome;neonate;Neonatology;Newborn Infant;novel;Nurses;Ondansetron;Opioid;opioid exposure;opioid use disorder;patient population;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;pharmacometrics;Philadelphia;post pregnancy;Pregnancy;Productivity;programs;Protocols documentation;Public Health;Publications;Publishing;Randomized, Controlled Trials;Recording of previous events;Regimen;Registries;Rehabilitation therapy;Research;Research Design;Research Personnel;sample collection;Sampling;Severities;Site;social stigma;Standardization;stem;Structure;Substance abuse problem;Substance Use Disorder;Supportive care;Symptoms;Therapeutic;treatment optimization;Universities;University Hospitals;Visit;ward;Woman;women's treatment;Work

PROJECT_TITLE: Thomas Jefferson University Hospital Clinical Site for HEAL NOWS Pharmacologic Trial


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: Narrative Aggressive periodontitis, now named Grade C periodontitis (C/MIP), is a group of less frequently, often severe and rapidly progressive form of periodontitis, affecting young individuals at an early age, usually aggregating in families of lower social economic background. The factors that render affected individuals to C/MIP disease are yet to be clearly identified, which affects the proper control of this aggressive disease. This multi-center study will gather clearly-defined cases of C/MIP from different regions of the globe and within families, to evaluate genetic susceptibility variants using whole exome sequencing, host response via epithelial cell transcriptome to pinpoint mechanistic pathways associated with C/MIP and with genetic variants, and microbial community profile via metagenomics as well as specific species strains associated with this disease.

PI_NAMEs: SHADDOX, LUCIANA MACCHION (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Academy;Actinobacillus actinomycetemcomitans;Adopted;Affect;African ancestry;Age;American;Bacteria;candidate identification;case control;Characteristics;Clinical;cohort;Communities;Complex;data integration;Development;Diagnosis;Dideoxy Chain Termination DNA Sequencing;Disease;disease diagnosis;Disease Progression;DNA;DNA sequencing;early onset;Economics;Environment;Environmental Exposure;Epithelial Cells;Esthetics;Etiology;European;Exhibits;exome sequencing;Family;gene interaction;Genes;Genetic;genetic association;Genetic Predisposition to Disease;genetic variant;genome-wide analysis;Genotype;Geographic Locations;Gingival Crevicular Fluid;Goals;high risk;Immune response;Incisor;Individual;individualized medicine;Inflammation Mediators;Inflammatory;Inflammatory Response;Link;metagenome;Metagenomics;microbial;microbial colonization;microbial community;microbiome;Molecular;Multicenter Studies;Names;neutrophil;older adult;Oral;oral cavity epithelium;oral microbiome;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Periodontitis;peripheral blood;Phenotype;Population;Predisposition;Property;Public Health;Rehabilitation therapy;Saliva;Sampling;Series;Shotguns;Siblings;Site;social;Susceptibility Gene;targeted treatment;Taxonomy;Terminology;Testing;Tooth structure;transcriptome;transcriptome sequencing;Variant;Virulence;Virulent;Work

PROJECT_TITLE: Susceptibility Patterns for Grade C Periodontitis in Young Individuals


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The proposed research is relevant to public health because it focuses on developing a novel technology for mapping senescent cells in human tissues. This technology will be used to spatially map gene expression, protein, and open chromatin in cells with high spatial resolution. Thus, the proposed research is relevant to the NIH’s mission that pertains to understanding of the aging process and treatment of aging-related diseases.

PI_NAMEs: GU, LIANGCAI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acrylamides;Adult;Affinity;aging process;aging related disease;Antibodies;ATAC-seq;Bar Codes;Biological Assay;Cell Aging;Cell Communication;Cell model;cell type;Cells;cellular imaging;Chromatin;Chromosome Mapping;Collaborations;combinatorial;Complex;cost;Data;Detection;Dissociation;DNA;Equipment;Excision;fabrication;Fishes;Gel;Gene Expression;Gene Expression Regulation;Generations;Goals;healthspan;Heart;Heterogeneity;Human;Human Cell Line;human tissue;image guided;improved;In Situ;In Vitro;in vivo;indexing;Individual;innovation;Laboratories;Libraries;Life;life span;Liver;luminescence resonance energy transfer;Lung;Maps;meter;Methodology;Methods;Microfluidics;Mission;model organism;Modification;Molecular;Morphology;multimodal data;multimodality;multiple omics;multiplexed imaging;Mus;nanobodies;new technology;novel;olfactory bulb;Organ;paracrine;Phase;Phenotype;Post-Translational Protein Processing;Production;programs;Protein Isoforms;Proteins;Proteome;Public Health;Reagent;Research;Research Personnel;Resolution;RNA;Running;scale up;senescence;senescence associated secretory phenotype;senescent cell;Site;Slide;Spatial Distribution;Specificity;Structure of parenchyma of lung;success;Surface;Surgeon;Techniques;Technology;Time;Tissue Donors;tissue mapping;Tissue Procurements;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: PIXEL-seq-based spatial, multi-omic profiling for senescent cell mapping with single-cell resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(70)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The mental health of adolescents in the United States has seen a steep decline since 2011, roughly coinciding with the increasing popularity of social media and smartphones. But does social media have a causal impact on the mental health of adolescents or are concerns about the effect of social media on kids a form of public hysteria? In this study, we will conduct the first field experiment in 11–14-year-olds to examine whether, how, and for whom social media harms mental health.

PI_NAMEs: KUSHLEV, KOSTADIN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 12 year old;14 year old;Address;Adolescent;adolescent mental health;Adult;Affect;Age;aged;anxiety symptoms;Attention;boys;Cellular Phone;Child;child depression;Child Rearing;depressive symptoms;design;Ethnic Origin;Exhibits;experience;Experimental Designs;experimental study;Exposure to;Future;Gender;girls;Grain;Hysteria;Image;Individual;Instagram;intersectionality;Intervention;Knowledge;Link;Literature;Machine Learning;Measurement;Measures;media use;Mediating;Mental Health;mobile sensing;Neurocognitive Deficit;Outcome;Parents;Participant;Patient Self-Report;Persons;Physical activity;Policy Maker;Population;psychologic;Race;Randomized;recruit;Reporting;Research;Research Personnel;Rewards;Risk Factors;Role;Scientific Advances and Accomplishments;Sleep;sleep quantity;social;social capital;Social Interaction;social media;Stimulus;systems research;Teenagers;Testing;TikTok;Time;tool;United States;university student;virtual

PROJECT_TITLE: Causal Effects of Exposure to Social Media on Adolescent Mental Health


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Polysubstance use such as commonly used gateway drugs - alcohol, tobacco and cannabis (ATC) is associated with numerous and deleterious consequences for college-attending emerging adults, however they are often unmotivated to quit or reduce drug use. Recent research has shown that mindfulness intervention is effective for craving and ATC reduction but the underlying mechanisms remain unclear. The proposed study will examine brain mechanisms of a brief mindfulness intervention - IBMT that targets at self-control networks in the brain, and test whether combing with EEG Neurofeedback (NF) could optimize IBMT effects on ATC reduction.

PI_NAMEs: TANG, YIYUAN  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: addiction;Address;Alcohol consumption;Alcoholic Intoxication;Alcohols;Anterior;Brain;Cancer Etiology;Cannabis;Cannabis policy;Cause of Death;Cessation of life;cingulate cortex;Clinical;college;Corpus striatum structure;craving;Drug usage;Electroencephalography;emerging adult;Goals;high risk;improved;Link;marijuana use;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness meditation;neurofeedback;novel;Outcome;Pharmaceutical Preparations;polysubstance use;Prefrontal Cortex;Preventable cancer cause;Public Health;reduced alcohol use;Reporting;Research;Self Assessment;Self-control as a personality trait;Testing;Tobacco;Tobacco use;university student

PROJECT_TITLE: Brain mechanisms of reducing polysubstance use following a novel body-mind intervention


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NIRSUM LABORATORIES, INC.

ORG_STATE: NY

PHR: PROJECT NARRATIVE The ongoing epidemic of opioid abuse, overdoses, and deaths is unprecedented in severity. Current treatment options are limited and could be improved upon. The goal of this research is to develop a novel therapeutic agent for the treatment of opioid use disorder that has a better profile than currently available therapies.

PI_NAMEs: SHAH, NIKEJ  (contact);VOCCI, FRANK J.

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abbreviations;Abstinence;Acceleration;Adherence;adherence rate;Agonist;analytical method;Animals;antagonist;base;Belief;Benign;Binding;Buprenorphine;Canis familiaris;carcinogenicity;Categories;Cessation of life;child bearing;Client;Clinical;Clinical Trials;Collaborations;Consultations;Contracts;Criminal Justice;design;Development;Dose;drug development;Drug Kinetics;Employment;Esters;experience;FDA approved;Fentanyl;fighting;Formulation;Goals;Half-Life;Head;healthy volunteer;Human;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Individual;Injectable;Injections;Intramuscular;Investigation;Investigational Drugs;Lead;lead candidate;Learning;Legal patent;lipophilicity;manufacture;manufacturing organization;Measures;Methadone;Military Personnel;Modeling;mu opioid receptors;nalmefene;Naltrexone;novel;novel therapeutics;Opioid;opioid abuse;Opioid Antagonist;opioid epidemic;opioid therapy;opioid use disorder;Oral;Outcome;Overdose;Patient Compliance;patient retention;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Phase;phase 1 study;phase 2 designs;phase 2 study;Phase II Clinical Trials;phase II trial;phase III trial;Plasma;preference;Pregnancy;pregnant;Prodrugs;Public Health;Qualifying;Rattus;Regulatory Pathway;Relapse;Research;Research Contracts;Research Personnel;retention rate;Risk;Rodent;Safety;scale up;Series;Severities;simulation;small molecule;stem;Sterility;synthetic opioid;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;timeline;Toxic effect;Toxicology;Translating;Treatment Failure;weapons;Woman;Work

PROJECT_TITLE: Development of a novel drug for treating opioid use disorder