ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Patient Safety;Substance Misuse

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE This proposal seeks to organize genes that have been linked to alcohol-related phenotypes into biological modules to elucidate novel pathways implicated in alcohol use and alcohol use disorder. The proposal will then explore drug-protein interactions with these implicated targets to identify promising drugs for repurposing to treat alcohol use disorder. Finally, the study will leverage access to the entire Veterans Affairs electronic health records to explore if the impact of exposure to any of these drugs leads to improvements in alcohol use disorder and thus justifies follow-up testing in clinical trials for potential repurposing.

PI_NAMEs: GRAY, JOSHUA CHARLES (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Adult;Affect;Alcohol abuse;Alcohol consumption;alcohol risk;alcohol use disorder;Alcohols;Algorithms;Biological;Biological Process;Caring;Catalogs;causal variant;Chromatin;Chronic Disease;Clinical Trials;cohort;Data;Data Set;Development;Diagnosis;Disease;drinking;drug candidate;drug development;Drug Exposure;Drug Interactions;drug repurposing;Drug Targeting;Electronic Health Record;Evaluation;Exposure to;follow-up;Future;Gene Structure;Genes;Genetic;genetic analysis;Genome;genome wide association study;genome-wide;Genomics;Goals;Health;Impairment;improved;Informatics;Infrastructure;innovation;Integrated Health Care Systems;Link;Measures;Medical;Methods;Molecular Conformation;multiple omics;novel;Occupational;Occupations;Ontology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;preclinical study;Proteins;Psychiatry;psychogenetics;Quantitative Trait Loci;Reporting;Research;Review Literature;Risk;Scoring Method;Single Nucleotide Polymorphism;social;success;Testing;Therapeutic;United States Department of Veterans Affairs;United States Food and Drug Administration;Untranslated RNA;work-study

PROJECT_TITLE: Leveraging genetic and electronic health record data to identify novel targets and drugs for treating alcohol use disorder

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Pain Research;Physical Activity

ORG_CITY: STORRS-MANSFIELD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: By identifying specific mechanisms through which yoga influences pain, the proposed study will advance the scientific study of yoga for multiple pain-related conditions, strengthen the evidence base on yoga for CLBP (facilitating healthcare providers' confidence and likelihood in prescribing yoga), and provide specific directions for optimizing yoga to increase its effectiveness for treating CLBP, one of the most prevalent and costly health conditions in the US.

PI_NAMEs: PARK, CRYSTAL L. (contact);STARKWEATHER, ANGELA RENEE

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Affect;Biological Testing;Chronic low back pain;chronic pain patient;Clinical;clinical effect;disability;Effectiveness;emotion regulation;emotional reaction;Emotions;evidence base;Evidence based treatment;follow-up;functional improvement;Gene Expression Profile;Goals;Health Care Costs;Health Personnel;improved;Individual;innovation;Integrative Therapy;Intervention;Link;Mediating;Mediator;Meditation;Modeling;Monitor;neurobiological mechanism;Outcome;Pain;Pain intensity;Pain Measurement;pain perception;pain reduction;Pathway interactions;Persons;Population;post intervention;Practice Guidelines;Process;psychologic;Randomized, Controlled Trials;Research;Role;Scientific Advances and Accomplishments;secondary outcome;Severities;skills;somatosensory;Stretching;Testing;theories;Therapeutic;Yoga

PROJECT_TITLE: Emotion regulation as a primary mechanism of action in yoga interventions for chronic low back pain: An RCT testing biological and psychological pathways

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE: Steatosis, the earliest manifestation of alcohol-associated liver disease (ALD), is often benign and reversible. However, it is widely believed to be the precursor to fibrosis, cirrhosis and cancer and therefore is a prime target for therapeutic intervention. The goal of this proposal is to examine the mechanistic role of gut hormones in the development of alcohol-associated hepatic steatosis. We will investigate how a gut-hormone, ghrelin, whose circulating levels are increased by alcohol consumption, can affect the activity/levels of other hormones to alter the gut-adipose-liver interactions to ultimately lead to the development of hepatic steatosis. Successful completion of the proposed studies will help us to gain mechanistic insights into understanding ghrelin’s role in modulating the organ-organ interactions to promote the development of alcohol-associated hepatic steatosis and hopefully provide some strategies to prevent ALD pathogenesis and progression.

PI_NAMEs: RASINENI, KARUNA  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholic Liver Diseases;Alcohols;Animal Model;antagonist;anti-microbial peptide;Attenuated;Benign;Biological;carbohydrate metabolism;Chronic;chronic alcohol ingestion;Cirrhosis;Complex;Development;Energy Metabolism;Ethanol;Experimental Animal Model;Fatty Acids;Fatty Liver;fatty liver disease;Fibrosis;Functional disorder;Gastrointestinal Hormones;ghrelin;ghrelin receptor;glucagon-like peptide 1;Goals;Hepatic;Hepatitis;Hepatocyte;hepatoprotective;Hormones;Human;Impairment;improved;In Vitro;Inflammation Mediators;innovation;insight;Insulin;insulin secretion;insulin sensitivity;interest;Knock-out;lipid metabolism;Lipids;Lipolysis;Liver;Liver diseases;Malignant Neoplasms;Mediating;Metabolic Diseases;Metabolism;Nonesterified Fatty Acids;Organ;oxidation;Pancreas;Pathogenesis;Pathologic;Pathology;peptide hormone;Peptides;prevent;problem drinker;Rattus;Receptor Mediated Signal Transduction;Reporting;Resistance;Role;Serum;Signal Transduction;Stomach;Structure of beta Cell of islet;targeted treatment;Technology;Testing;Therapeutic Intervention;Therapeutic Uses;uptake

PROJECT_TITLE: Role of alcohol-induced ghrelin in modulating organ crosstalk to promote the development of fatty liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chronic alcohol exposure produces tolerance to alcohol’s aversive properties, which functions to release the brake on drinking, contributing to difficulty controlling consumption. The neurobiological mechanisms underlying this effect are not well understood but likely include alterations in neural circuits involved in aversive signaling. The project proposed in the current application will examine the role of inputs from functionally distinct subregions of the medial prefrontal cortex to the rostromedial tegmental nucleus in driving chronic tolerance to alcohol’s aversive properties.

PI_NAMEs: GLOVER, ELIZABETH J (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol response;alcohol reward;alcohol use disorder;Alcohols;Attenuated;Automobile Driving;Aversive Stimulus;avoidance behavior;Behavior;behavioral extinction;behavioral response;Brain;Calcium Signaling;Cell Nucleus;Cells;Chronic;Consumption;Data;Dendritic Spines;density;Dependence;design;Development;drinking;Electrophysiology (science);Equilibrium;Ethanol;experience;Experimental Designs;experimental study;Exposure to;Extinction;Feedback;Fiber;Fright;Health;Human;Impairment;in vivo;Individual;innovation;insight;Intoxication;Learning;Link;loss of function;Measures;Medial;Mediating;Midbrain structure;Morphology;neural circuit;neuroadaptation;neurobiological mechanism;neuromechanism;neuron loss;Neuronal Plasticity;Neurons;new therapeutic target;optogenetics;patch clamp;Photometry;Play;Prefrontal Cortex;Property;Public Health;Rattus;response;Rewards;Role;Signal Transduction;Slice;Stimulus;Synapses;Synaptic plasticity;Taste aversion;Testing;Viral;Work

PROJECT_TITLE: Neurobiological mechanisms underlying chronic tolerance to the aversive properties of ethanol

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Pancreatic cancer is a deadly disease because of the high incidence of systemic metastases at the time of diagnosis and the lack of sufficient therapeutic agents. The overall objective of this proposal is to determine if eIF5A2 protein regulates invadopodium formation to drive metastatic pancreatic cancer using preclinical mouse models that closely recapitulate the human disease.

PI_NAMEs: KLEMKE, RICHARD L. (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Actins;Adhesives;Architecture;base;Basement membrane;Biochemical;Biological Markers;Blood Vessels;Brain;cancer cell;Capsid Proteins;cell growth;cell motility;Cell Proliferation;Cell surface;Cell Surface Extensions;cell transformation;Cells;Circulation;clinically relevant;Collagen;Complex;confocal imaging;Cues;Cytoskeleton;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;DNA Sequence Alteration;druggable target;Elongation Factor;Environment;ERBB2 gene;Erythrocytes;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;F-Actin;fighting;Fingerprint;Genetic Transcription;Human;human disease;Immunocompetent;In Vitro;Incidence;innovation;Invaded;Investigation;KRAS oncogenesis;Label;Laboratories;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuals;Mediating;Membrane;Messenger RNA;meter;Methods;mouse model;mRNA Translation;mutant;Mutation;Neoplasm Metastasis;novel;novel therapeutic intervention;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Initiation Factors;Phosphotransferases;Platelet-Derived Growth Factor beta Receptor;Play;Porosity;pre-clinical;Process;Proliferating;Protein Biosynthesis;protein expression;Protein Isoforms;Protein Tyrosine Kinase;Proteins;Proteomics;Pseudopodia;Publishing;RNA;Role;Route;Shapes;Signal Transduction;Stains;Stromal Invasion;Structure;Surface;Survival Rate;Tail;Technology;Testing;Testis;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;Time;Tissues;Translating;Translations;tumor;War;Work

PROJECT_TITLE: Discovering Spatial Mechanisms Regulating Metastatic Invadopodia in PDAC

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is a common condition of severe respiratory failure precipitated by a variety of insults (e.g., Covid-19 and other respiratory viruses, sepsis, and pneumonia), with hospital mortality of 30–40% and significant morbidity among survivors. ARDS randomized clinical trials (RCTs) have been hampered by (1) analyses that yield a strict binary conclusion concerning treatment efficacy, (2) inadequate statistical methods to assess heterogeneity of treatment effect among varying patient types, and (3) death- truncated non-mortality outcomes such as length of stay. To offer more intuitive probabilistic interpretations of an intervention’s efficacy and thus maximally leverage the information learned from a trial, the researchers will apply a suite of Bayesian causal inference and machine learning methods to 29 international and NIH/NHLBI- funded multicenter ARDS RCTs to (1) determine the probability that the tested interventions produce benefit or harm on the absolute and relative scale for both mortality and non-mortality clinical outcomes, (2) quantify the degree of confidence in these conclusions, and (3) identify clinically meaningful subgroups most likely to benefit.

PI_NAMEs: HARHAY, MICHAEL OSCAR (contact);LI, FAN

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;adjudication;Adrenal Cortex Hormones;Adverse event;Advocate;Agonist;Bayesian Method;Bayesian Modeling;Belief;Cessation of life;Characteristics;Clinical;Clinical effectiveness;clinical efficacy;Clinical Practice Guideline;clinical trial enrollment;clinically relevant;cloud based;Cognitive;Complex;Computer software;cost;COVID-19;Data;design;Detection;Disease;Epidemiology;Ergocalciferols;evidence base;falls;Formulation;Funding;Future;Heterogeneity;Hospital Mortality;improved;improved outcome;Individual;innovation;insight;International;Intervention;Intuition;Investigation;Knowledge;Learning;Length of Stay;Liquid substance;machine learning method;Meta-Analysis;Methodology;Methods;Modernization;Modification;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neuromuscular Blocking Agents;novel;novel strategies;Outcome;Output;participant enrollment;patient subsets;Patients;Pneumonia;prevent;Probability;Prone Position;psychosocial;Publishing;randomized, clinical trials;Recommendation;regression trees;Research;Research Personnel;Respiratory Failure;respiratory virus;Sepsis;Societies;Specific qualifier value;Standardization;Statistical Methods;Subgroup;Survivors;Syndrome;Techniques;Testing;Tidal Volume;tool;treatment effect;Treatment Efficacy;treatment response;trial design;United States National Institutes of Health;Variant;ventilation;Ventilator;Vitamin D;web-based tool;Work

PROJECT_TITLE: Advancing the design, analysis, and interpretation of acute respiratory distress syndrome trials using modern statistical tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(90)S]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Graduate Training Program in Bioinformatics Program Narrative The National Institutes of Health (NIH) has recognized that there is a critical need for interdisciplinary training that integrates the biomedical, computational and engineering sciences, in order to harness the opportunities of the post-genomic era, to furthering the health sciences research and improving health care outcomes. The purpose of this doctoral training program is to train students in the interdisciplinary subject of Bioinformatics and Systems Biology, and thereby serve the NIH mission.

PI_NAMEs: BAFNA, VINEET ;GAASTERLAND, THERESA ;SUBRAMANIAM, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Bioinformatics;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Brain metastasis represents the last stage of cancer, for which there are no therapies to date. We have found that ablation of regulatory T cells, which infiltrate primary tumors and metastasis and correlate with poor prognosis, strongly suppresses brain metastasis, and control reactive gliosis. A better understanding of the mechanisms controlling the cross talk among Treg cells, reactive astrocytes and tumor cells may lead to new approaches to combat this disease.

PI_NAMEs: BOS, PAULA DANIELA (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Ablation;Amphiregulin;Applications Grants;Astrocytes;astrogliosis;Bone Marrow;Bone Marrow Neoplasms;Brain;brain control;Brain Neoplasms;brain tissue;calcium absorption;cancer complication;Cancer Patient;CCL2 gene;Cell Line;Cell Physiology;Cells;Central Nervous System;Cephalic;chemotherapy;combat;Development;Disease;effector T cell;Encephalitis;Epidermal Growth Factor Receptor;Event;Flow Cytometry;FOXP3 gene;Fright;Genetic Models;Gliosis;Goals;Growth;Heterogeneity;Image;immune checkpoint blockade;Immune response;Immunofluorescence Immunologic;Immunohistochemistry;in vivo;Infiltration;Interferons;Lesion;Light;Malignant Neoplasms;Mediating;Metastasis Induction;Metastatic malignant neoplasm to brain;metastatic process;Modeling;Neoplasm Metastasis;neoplastic cell;Neurologic Symptoms;Neurons;novel;novel strategies;Outcome;Pathology;Pathway interactions;Patients;peripheral tolerance;Plasminogen Activator;Play;Population;Primary Neoplasm;Process;Production;Prognosis;Reactive Inhibition;receptor;recruit;Regulatory T-Lymphocyte;Research Proposals;Resistance;response;Role;Signal Transduction;Slice;STAT3 gene;stroke model;Systemic Therapy;Therapeutic;Time;tissue repair;Tissues;tumor;Tumor Burden

PROJECT_TITLE: Regulatory T cell modulation of reactive astrogliosis in brain metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Mental Health;Prevention;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Listeners who wear a cochlear implant exert extra effort while listening, a phenomenon that negatively impacts their quality of life, social communication, mental health, and can lead to greater levels of fatigue. The goal of the proposed research is to refine new techniques in physiological and behavioral assessment of listening effort and directly measure how momentary increase in effort can accumulate into fatigue. The results could lead to diagnostic procedures that better reflect real-world difficulties experienced by those with hearing loss and a better understanding of the mechanisms of listening effort and fatigue.

PI_NAMEs: SMITH, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Accidents;Address;Adult;Affect;Anxiety;Behavior assessment;behavior measurement;Behavioral;Behavioral inhibition;Clinical;Cochlear Implants;Cognitive;cognitive performance;cognitive process;Communication;Data;design;Development;Diagnostic Procedure;Disabling;Distress;Environment;experience;experimental study;Fatigue;Future;Goals;Grant;Hearing;hearing impairment;Ideal 1;Impaired cognition;improved;Individual;Institution;Instruction;interdisciplinary collaboration;Knowledge;language processing;Lead;Life;Measures;memory recall;Mental Fatigue;Mental Health;Mentorship;Methods;Mydriasis;National Institute on Deafness and Other Communication Disorders;Patients;Persons;Physiological;Process;Productivity;programs;Psyche structure;Pupil;Quality of life;Reaction Time;Recording of previous events;rehabilitation strategy;repair strategy;repaired;Reporting;Research;Retirement;Science;Self Perception;Sensory;Sick Leave;Social Behavior;social communication;Speech;Speech Perception;Statistical Data Interpretation;Stimulus;Stretching;Techniques;Time;Training;Work;Workplace;World Health Organization

PROJECT_TITLE: The impact of extra effort and accumulated fatigue in listeners who wear a cochlear implant


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Individuals with Alzheimer’s disease (AD) often suffer from motor problems such as slowness and loss of strength. Constructing a composite score of multiple motor domains in AD can result in a marker that could be used to indicate the risk to develop the disease. In the proposed study we will use machine learning to identify which motor measures are best used together to create such a composite score, and to define the neural mechanisms that underly motor dysfunction in AD.

PI_NAMEs: KOPPELMANS, VINCENT  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Affect;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;apolipoprotein E-4;Area;Assessment tool;Atrophic;Award;Behavioral;Biological Markers;Brain imaging;Brain region;Cerebellum;Cerebrospinal Fluid;Cerebrum;Classification;Clinical;clinical practice;Clinical Trials;Cognitive;Collaborations;Corticospinal Tracts;cost;cost efficient;Data;Development;Diagnostic;diagnostic tool;Disease;Elderly;Ensure;Environment;Etiology;Exhibits;expectation;Fostering;Goals;Growth;Hand Strength;Health Care Costs;Hippocampus;Impairment;improved;Individual;innovation;insight;Institution;Machine Learning;Magnetic Resonance Imaging;Measures;Mentors;Mentorship;mild cognitive impairment;Mission;Modeling;Motor;Motor Cortex;motor disorder;neural;Neurobehavioral Manifestations;Neurologic;neuromechanism;novel;novel marker;Patients;Performance;Population;Positron-Emission Tomography;predictive marker;predictive modeling;Predictive Value;Prevalence;prevent;Prevention trial;Preventive therapy;Process;random forest;Research;Research Personnel;Risk;Risk Factors;Role;Sample Size;Sampling;Sampling Studies;Series;skills;success;Testing;Training;treatment effect;Twin Studies;vector;Vietnam;walking speed;Work;β-amyloid burden

PROJECT_TITLE: Motor Profiles as Novel Biomarker for Alzheimer’s Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE T cell transcription factors (TFs) STAT3 and BATF play a critical role in CD4 T cell activation in response to influential cytokines; however, mice deficient for both STAT3 and BATF, but not each individual TF, developed spontaneous colitis that featured high numbers of inflammatory γδ T cells in the intestines. This recapitulates what is seen in human inflammatory bowel disease (IBD) patients and suggests that STAT3 and BATF- expressing CD4 T cells regulate intestinal homeostasis by controlling aberrant activation of gut γδ T cells to prevent IBD pathogenicity. Therefore, defining the mechanisms by which STAT3/BATF regulate this pathway will lead to identification of signaling pathways or cell surface proteins that may be therapeutically leveraged in treating IBD.

PI_NAMEs: ANDERSON, NICOLE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Advisory Committees;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Automobile Driving;Blocking Antibodies;career;Case Study;CD4 Positive T Lymphocytes;Cell Communication;Cell Culture Techniques;Cell Physiology;Cell Surface Proteins;cell type;Cells;Clinical;Clinical Immunology;Colitis;Colorectal Cancer;Communication;Complex;cytokine;Data;Development;Disease;disease model;Disease Progression;effective therapy;Exhibits;expectation;fecal microbiota;Functional disorder;Genetically Engineered Mouse;Genotype;Germ-Free;Gnotobiotic;Goals;gut inflammation;gut microbiota;Homeostasis;Human;Immune;Immune response;In Vitro;in vivo;Incidence;Individual;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Influentials;Interferon Type II;interleukin-23;Interleukin-6;Intestinal Diseases;intestinal homeostasis;Intestines;microbial community;microbiota;Modeling;Monitor;Monoclonal Antibodies;mouse model;Mus;new therapeutic target;Newly Diagnosed;novel;novel therapeutic intervention;Pathogenicity;Pathway interactions;Patients;Pattern;Persons;Play;Predisposition;prevent;Receptor Activation;Reporting;Research;Research Personnel;response;Role;Signal Pathway;Signal Transduction;skill acquisition;Sodium Dextran Sulfate;Spontaneous colitis;STAT3 gene;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;Training;transcription factor;Trinitrobenzenesulfonic Acid;Universities;Work;Writing;γδ T cells

PROJECT_TITLE: A T cell STAT3/BATF-axis regulates intestinal γδ T cell homeostasis and disease


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative: Suicide rates among veterans with Serious Mental Illness (SMI) are intractably high, representing a serious public health concern and a critical target for interventions. Yet, at present available treatments offer only limited benefits. Thus, there remains an urgent need to identify novel approaches to address suicide risk in this population. Previous reports have linked suicide risk with poor social functioning (SF). Emerging evidence from basic affective neuroscience research has indicated effective SF is contingent on intact emotion awareness. Consistent with these findings, individuals with SMI at risk of suicide display SF difficulties along with poor emotion awareness (i.e., alexithymia). Employing a proof-of-concept design, the aim of the present study is to test the feasibility and acceptability of a novel, blended psychoeducation and digital mHealth intervention with smartphones designed to target alexithymia and poor SF to reduce suicide risk in veterans with SMI.

PI_NAMEs: KIMHY, DAVID  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Affective;affective neuroscience;Aggressive behavior;Alexithymias;Awareness;behavioral health;Bipolar Disorder;Cellular Phone;Chronic;Clinical;clinical diagnostics;Clinical Trials;Data;design;Development;digital;Dose;efficacy testing;Emotional;emotional experience;Emotions;experience;feasibility testing;Feeling;Feeling suicidal;functional outcomes;Goals;Hospitals;improved;indexing;Individual;informant;innovation;Intervention;Interview;Link;Mental Depression;Mental Health;Meta-Analysis;Methods;mHealth;mhealth interventions;Neurosciences Research;novel;novel strategies;Numbness;Outcome;Participant;Patients;pharmacologic;Pilot Projects;Play;Population;Post-Traumatic Stress Disorders;Prevalence;prevention service;preventive intervention;programs;psychoeducation;psychosis risk;Psychotherapy;Public Health;Quality of life;randomized, clinical trials;Recording of previous events;recruit;reducing suicide;rehabilitation research;Rehabilitation therapy;Reporting;research and development;response;Risk;Sampling;Schizophrenia;service utilization;Services;severe mental illness;Signal Transduction;skills training;social;Social Functioning;social situation;Societies;Structure;Substance Use Disorder;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide hotline;Suicide prevention;suicide rate;Symptoms;Syndrome;systematic review;Technology;therapy design;therapy development;Treatment Efficacy;Treatment outcome;treatment response;Veterans;Violence

PROJECT_TITLE: Alexithymia Intervention for Suicide (ALEXIS)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Activity;Prevention;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Alcohol Use Disorder is a major public health concern in the United States and the causation of relapse can be explained by active avoidance of stress and anxiety. My project focuses on how exercise might manipulate a specific brain region to prevent these feelings of stress and anxiety during alcohol abstinence. In doing so, we hope to identify a simple treatment to prevent relapse during alcohol use disorder.

PI_NAMEs: ADANK, DANIELLE NICOLE (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acute;Affective;alcohol abstinence;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol sensitivity;alcohol use disorder;alcohol-related death;Alcohols;Amygdaloid structure;Animal Model;Anxiety;Automobile Driving;Behavior;Behavioral;Brain;brain circuitry;Brain region;career;cell cortex;Cells;Chronic;Communication;COVID-19 pandemic;Data;Dose;drinking;Electrophysiology (science);Ethanol;Etiology;Exercise;Exercise Test;Exposure to;feeding;Feeling;Fellowship;Fiber;follow-up;gamma-Aminobutyric Acid;Genetic;Grant;Health protection;Human;improved;in vivo;Individual;insight;Insula of Reil;Interneurons;Interoception;Investigation;Maps;Mediating;Methods;Motor Activity;Motor Cortex;Mus;negative affect;Neocortex;Neurons;Neuropeptides;Neurotransmitters;optogenetics;Pattern;Persons;Photometry;Play;prevent;preventable death;Property;Public Health;Quinine;rabies viral tracing;recruit;Regulation;Relapse;relapse prevention;Reporter;Research Personnel;Resistance;Rodent Model;Role;Running;Self Administration;sensor;Signal Transduction;skills;Somatostatin;Stress;Structure;Study models;Substance Use Disorder;Synapses;Techniques;Testing;transmission process;United States;Withdrawal

PROJECT_TITLE: Exercised-induced modulation of insular cortex microcircuitry during alcohol abstinence


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Coronaviruses;Infectious Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative  ISG15 is an important molecule in the innate immune response against a wide range of human viral and microbial pathogens, including Mycobacterium tuberculosis and SARS-CoV-2. ISG15 has three distinct and separable biochemical functions and a major goal of this project is to understand how these activities are regulated and coordinately controlled. We anticipate that this will lead to the development of novel antiviral and antimicrobial therapies for important human infectious diseases.

PI_NAMEs: HUIBREGTSE, JON  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;antimicrobial;Area;betacoronavirus;Binding;Biochemical;Biological;Cell Physiology;Cell Surface Receptors;cell type;Cells;Communicable Diseases;Coronavirus;cytokine;Development;Directed Molecular Evolution;Disease;Enzymes;Event;extracellular;Extracellular Space;Family;gene product;Genetic Transcription;Goals;Homologous Gene;Human;human pathogen;Immune;improved;Infection;Innate Immune Response;insight;Integrins;Interferon alpha;Interferon Type I;Interferon Type II;Interferons;Interleukin-10;Interleukin-6;Intervention;ISG15 gene;Ligase;Lysine;Mediating;microbial;Molecular;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;novel;pathogen;pathogenic microbe;pathogenic virus;Patients;Play;Predisposition;Principal Investigator;Process;programs;protein function;Proteins;Proteomics;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Site;Structure;T-Lymphocyte;Type I Interferonopathy;Ubiquitin;Ubiquitin Like Proteins;Variant;Vesicle;Viral;Viral Physiology;Viral Proteins;Virus

PROJECT_TITLE: Mechanism and Function of ISG15

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Despite its importance to human health, proprioception is perhaps the most poorly understood of all the senses. This proposal applies innovative methods to gain detailed insights into the circuit, cellular, and synaptic mechanisms of proprioceptive neural processing. An improved understanding of proprioception is essential for developing therapeutic strategies to treat somatosensory disorders such as chronic pain.

PI_NAMEs: TUTHILL, JOHN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Anatomy;Animals;arm;arm movement;Award;Axon;Behavior;Behavioral;body position;Calcium;cell type;Central Nervous System;chronic pain;Code;Computer Models;Development;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Feedback;flexibility;fly;Genetic;Genetic Models;Health;Human;Image;improved;innovation;insight;Interneurons;Invertebrates;Joints;kinematics;Label;Leg;limb movement;Limb structure;Maps;Measures;mechanical force;Methods;model organism;Modeling;Morphology;Motor;motor behavior;motor control;Movement;Movement Disorders;Muscle Spindles;Musculoskeletal Equilibrium;Nerve;neural;neuromechanism;Neurons;optogenetics;Patients;Peripheral;peripheral nerve damage;Phase;Positioning Attribute;Posture;presynaptic;Process;Proprioception;Proprioceptor;Research;response;Role;Scheme;sensor;sensory feedback;Signal Transduction;Site;somatosensory;Somatosensory Disorders;Specificity;Speed;Spinal Cord;Synapses;synaptic inhibition;System;Therapeutic;tool;two-photon;Vertebrates;vibration;Walking

PROJECT_TITLE: Neural coding of leg proprioception

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Collective cell migration is a critical component of both normal intestinal function and repair following injury or disease. However, how intestinal epithelial cells coordinate this migration is still virtually unknown. With defects in collective cell migration increasingly implicated in a wide array of human diseases, understanding how this process is coordinated is critical to developing new interventions and treatment strategies.

PI_NAMEs: BREAU, KEITH  (contact)

PROJECT_TERMS: Adopted;Adult;Affect;Applications Grants;Biliary;Biological Models;biological systems;cell injury;cell motility;Cell Physiology;Cell Polarity;Cell Surface Proteins;Cell Surface Receptors;Cell-Cell Adhesion;Cells;Chronic;Colitis;combat;Complex;Computer Models;Confocal Microscopy;Data;Dedications;Defect;design;Development;Devices;Differential Equation;Diffusion;Disease;Distal;Drosophila genus;Duct (organ) structure;Epithelial Cells;epithelial wound;Epithelium;fabrication;Feedback;Formulation;Genetic Models;Goals;Grant;Health;Homeostasis;Human;human disease;human migration;human model;Hybrids;imaging Segmentation;Impairment;in vivo;Individual;Injury;injury and repair;Intercellular Junctions;Intervention;intestinal epithelium;Intestines;Kidney Diseases;knock-down;Knock-out;Knowledge;Ligands;Liquid substance;Machine Learning;mathematical model;Measures;Membrane;Mentorship;Methods;migration;Modeling;monolayer;mutant;Natural regeneration;Neoplasm Metastasis;Nervous System Disorder;novel;Nutrient;Organism;overexpression;Paper;pathogen;Pathway interactions;Phenotype;physiologic model;Physiological;planar cell polarity;Play;preservation;Process;Proliferating;Proteins;Publishing;Reaction;Regulation;repaired;Research;Role;Side;Signal Transduction;Skeletal Muscle;small hairpin RNA;spatiotemporal;Specific qualifier value;Speed;Stains;stem cells;Stream;Study models;Surface;Testing;Therapeutic Intervention;Tissues;tool;Training;treatment strategy;uptake;Villus;virtual;wound;wound healing;Writing

PROJECT_TITLE: Investigating a role for Wnt-associated planar polarity in collective migration of human intestinal epithelium


ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: A small protein called ubiquitin (and a small family of similar proteins) regulates the growth, division, and behavior of all human cells and those of virtually all organisms with a nucleus. Ubiquitin is attached to specific cellular proteins, and this often causes the degradation of the tagged protein; defects in the enzymes controlling these processes are known to cause human neurodegenerative disorders, developmental abnormalities, and various cancers. This project aims to deepen our understanding of the key enzymes that attach ubiquitin to and remove it from proteins and the mechanism of degrading the tagged proteins, with the long-term goal of developing therapies to treat patients suffering from neurodegenerative disease, diabetes, cancer, or certain infectious diseases.

PI_NAMEs: HOCHSTRASSER, MARK W (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Adaptor Signaling Protein;Address;Aneuploidy;Area;Arthropods;Bacteria;Behavior;Binding;Cell Nucleus;Cells;Chromosomes;Clathrin Adaptors;Communicable Diseases;Culicidae;deep sequencing;Defect;Dengue Fever;Development;Diabetes Mellitus;Disease;Disease Vectors;drug development;Drug Targeting;Enzymes;Eukaryotic Cell;Evolution;Family;fighting;Generations;Goals;Growth;Human;Human Biology;In Vitro;Infection;interest;Ligation;Link;Lysosomes;Malaria;Malignant Neoplasms;Modification;Monomeric GTP-Binding Proteins;Movement;multicatalytic endopeptidase complex;Neurodegenerative Disorders;Organism;pathogen;Patients;Peptide Hydrolases;Phospholipids;Physiological;polypeptide;Post-Translational Protein Processing;Process;Proteins;Proteolysis;Quality Control;Reaction;Regulation;Reproduction;Research;response;Ribosomes;Role;Saccharomyces cerevisiae;Scrub Typhus;Starvation;System;Technology;therapy development;transmission process;Ubiquitin;virtual;Wolbachia;yeast protein

PROJECT_TITLE: Mechanisms of Cell Regulation and Manipulation by the Ubiquitin System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Narrative Skp2 SCF complex E3 ligase is a highly validated drug target for cancer. Due to the lack of effective inhibitors, Skp2 SCF complex E3 ligase is considered as non-drugable. Drug development of the Skp2 proteolysis targeting chimera (PROTAC) drugs with superior potency and safety window would transfer Skp2 to be durgable for the treatment of cancer.

PI_NAMEs: LI, HONG-YU  (contact);LIN, HUI-KUAN

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: absorption;analog;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Back;BCL2 gene;Binding;Biological Assay;Biological Availability;cancer cell;Cancer Patient;cancer therapy;Cell Cycle;Cell Cycle Progression;cell killing;Cells;chemical synthesis;chimera drug;clinical candidate;Complex;cytotoxicity;Data;design;Development;Dose;drug candidate;drug development;Drug Kinetics;Drug Targeting;Excretory function;Failure;Funding;Genetic;Growth Factor;Human;Immunity;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;inhibitor;Intravenous;Link;Liver Microsomes;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;MDM2 gene;Mediating;Membrane;Metabolism;Metastatic Prostate Cancer;meter;Modeling;mouse model;Mus;Normal Cell;novel;Oral;Organoids;Paper;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;phase 1 study;Phase I Clinical Trials;Phenotype;Plasma;Process;Property;prostate cancer model;prostate cancer progression;Protac;protein protein interaction;Proteins;recruit;Resistance;Safety;scale up;Signal Transduction;Skp2 Proteins;small molecule inhibitor;Specimen;Testing;Therapeutic;tumor;ubiquitin-protein ligase;Ubiquitination;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Drug Development of Skp2 PROTACs in Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Primary Health Care;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with uncomplicated pregnancies. This research investigates a patient-centered intervention during the postpartum period to promote engagement in cardiovascular preventive care. Leveraging the association between hypertensive disorders of pregnancy and cardiovascular disease to provide effective preventive health interventions may ultimately prevent cardiovascular death and disability among women.

PI_NAMEs: THEILEN, LAUREN  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;American Heart Association;Area;Attitude;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Caring;Cause of Death;Cessation of life;Client satisfaction;Clinical;clinical care;Clinical Trials;Communication;communication aid;Conduct Clinical Trials;Data;Decision Aid;Decision Making;design;Development;disability;Discipline of obstetrics;efficacy testing;Event;evidence base;Evidence based intervention;Future;Goals;Health;healthy pregnancy;Heart Diseases;high risk;High Risk Woman;Hypertension;improved;Incidence;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Learning;Life;life span;lifetime risk;Maternal Health;Maternal-fetal medicine;member;men;Mentors;obstetric care;Outcome;Patient Education;patient engagement;patient oriented;Patient risk;Patient-Focused Outcomes;Patients;Perinatal;Persons;Physicians;Pilot Projects;pilot trial;Populations at Risk;Positioning Attribute;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Complications;pregnancy disorder;prevent;Prevention;Preventive;Preventive care;primary care provider;Process;programs;prototype;Provider;Recommendation;reproductive;Research;Research Methodology;Research Personnel;Risk;Self Care;Self Efficacy;Silver;skills;Specialist;standard care;Stroke;Structure;Symptoms;Testing;therapy design;tool;Training;trial comparing;trial design;United States;Woman;Women's Health;Women's mortality;Work

PROJECT_TITLE: Optimizing Cardiovascular Preventive Care for Women following Hypertensive Disorders of Pregnancy.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Machine Learning and Artificial Intelligence;Precision Medicine;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Alcoholic hepatitis (AH) is a severe acute form of alcoholic liver disease with a very high mortality rate. Despite years of research, the standard-of-care and mortality rate has not changed dramatically in over 50 years. Our goal is to develop new computational and experimental methods and discover new biomarkers for AH outcome that can efficiently identify at-risk individuals. A second goal of the project is to identify molecular mechanisms of AH, which could be targeted therapeutically.

PI_NAMEs: ARTEEL, GAVIN E (contact);BENOS, PANAGIOTIS V;MERCHANT, MICHAEL L

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acute;acute liver injury;Address;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;algorithm development;Algorithms;Area;Biological;Biological Markers;Biology;biomarker discovery;biomarker identification;Cells;chronic alcohol ingestion;Clinical Data;cohort;Collagen;Data;Death Rate;design;Development;diagnostic tool;Disease;Extracellular Matrix;Extracellular Matrix Proteins;Generations;Goals;Graph;graph learning;Health;Hepatic;Homeostasis;Human;improved;Individual;individual patient;Informatics;Injury;insight;interest;Lead;learning algorithm;Link;Liquid substance;Liver diseases;Liver Fibrosis;machine learning method;Matrix Metalloproteinases;Mediating;Medical;Methods;minimally invasive;Modeling;Molecular;Molecular Weight;mortality;mouse model;Multiple Organ Failure;Multivariate Analysis;Neoplasm Metastasis;new therapeutic target;novel;novel diagnostics;organ injury;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Peptide Synthesis;Peptides;Plasma;Population;predictive marker;predictive tools;Predictive Value;Process;Production;profiles in patients;Prognosis;Prognostic Marker;prospective;Protease Inhibitor;Protein Fragment;Proteins;Research;Risk;risk prediction;Role;Severities;Signal Transduction;standard of care;Supportive care;targeted treatment;Testing;Tissues;tool;Translating;Work

PROJECT_TITLE: Biomarkers of Alcoholic Hepatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: The goals of our research are to identify and characterize the molecular machinery that contributes to synaptic signaling in the nervous system, with a focus on signaling mediated by the excitatory neurotransmitter glutamate and mediated by ionotropic glutamate receptors (iGluRs). Our goal is to obtain a mechanistic understanding of how neuropeptide signaling regulates the function of NMDA-type iGluRs, with a focus on specific peptide ligands and G-protein coupled receptors. These studies could provide new insights into the disordered synaptic function characteristic of many neurological disorders, identify new drug targets for therapeutic intervention, and ultimately contribute to the development of new therapeutic modalities for the treatment of neurological and psychiatric disorders.

PI_NAMEs: MARICQ, ANDRES VILLU (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Alzheimer's Disease;Attention;Behavior;Behavioral;behavioral phenotyping;behavioral study;Brain;Caenorhabditis elegans;Cell model;Cells;Characteristics;Confocal Microscopy;Defect;Dependence;Development;Disease;Electrophysiology (science);experimental study;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Hyperactivity;in vivo;information processing;insight;interdisciplinary approach;Interneurons;Intervention;Learning;Ligands;Link;Locomotion;loss of function;loss of function mutation;Measures;Mediating;Memory;Memory Loss;Mental disorders;Modality;model organism;Modeling;Molecular;mutant;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nervous System;Nervous System Disorder;nervous system disorder therapy;Nervous System Physiology;Neurodegenerative Disorders;Neurologic;Neuromodulator;neuron loss;Neurons;Neuropeptide Receptor;Neuropeptides;neurotransmission;Neurotransmitters;new therapeutic target;novel therapeutic intervention;novel therapeutics;optogenetics;Pathway interactions;Peptides;pharmacologic;Pharmacologic Substance;Phenocopy;Physiological Processes;Pigments;postsynaptic;presynaptic;presynaptic neurons;Process;Production;Proteins;receptor;Receptor Signaling;receptor-mediated signaling;Research;Role;Signal Pathway;Signal Transduction;Synapses;synaptic function;Synaptic Transmission;System;Techniques;Testing;Therapeutic Intervention;Time

PROJECT_TITLE: Peptidergic Modulation of NMDA-Receptor Mediated Neurotransmission

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative (3 sentences) In this project, we aim to better understand the comparative radiobiology of the alpha emitting drug [211At]PTT in tumor and normal tissues. We will develop an optimized strategy for translation to clinical trials in women with advanced PARPi resistant ovarian cancer. The PET imaging companion diagnostic [18F]FTT will be developed in parallel as a prognostic biomarker as well as for image-guided treatment planning.

PI_NAMEs: FARWELL, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Alpha Particles;Area Under Curve;Autoradiography;Biodistribution;Biological;cancer cell;Cell Line;Cell Nucleus;Cell-Mediated Cytolysis;Cells;Cessation of life;clinical practice;clinical translation;Clinical Trials;combat;companion diagnostics;comparative;Cytoplasm;cytotoxic;cytotoxicity;Data;Deposition;DNA Double Strand Break;DNA Repair;Dose;Dose Fractionation;Dose Limiting;dosimetry;Drug Combinations;Drug Kinetics;first-in-human;Fractionation;Germ Lines;Hematopoietic;homologous recombination deficiency;image guided;Immunocompetent;improved;insight;Kinetics;Label;Lead;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Measures;Mediating;Modeling;mouse model;Mus;Neuroblastoma;Normal tissue morphology;Nuclear;Organ;PARP inhibition;particle therapy;Patient Selection;Patients;Pediatric Neoplasm;PET/CT scan;Pharmaceutical Preparations;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;preclinical trial;predictive marker;Prognostic Marker;protective effect;Radiobiology;Radiopharmaceuticals;Resistance;Resistance development;response;Risk;Scheme;small molecule;standard care;standard of care;Survival Rate;targeted agent;Testing;theranostics;Therapeutic;Tissues;Toxic effect;translational approach;treatment planning;tumor;Tumor Tissue;uptake;Visualization;Woman;women's clinical trial

PROJECT_TITLE: Optimizing theranostic radiopharmaceutical therapy to combat resistance to PARP inhibition in advanced ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-R(56)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Disability Research;Lung;Mucopolysaccharidoses (MPS);Pediatric;Rare Diseases;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: 8. Project Narrative Morquio A disease is a devastating systemic skeletal disease in which detailed progression and pathogenesis remain unknown. The proposed project aims to establish a non-invasive objective assessment that can be applicable to all ages of patients to better understand the progress of their disease and the most serious clinical problems (cervical instability and stenosis, tracheal obstruction, hyperlaxity of joints, hip dysplasia, and small lung capacity). The outcome of this project will lead to a more precise understanding of the skeletal/pulmonary compromise and defining clinical endpoints in this disease for future clinical trials of current or developing therapies. 1

PI_NAMEs: TOMATSU, SHUNJI  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acetylgalactosamine;Activities of Daily Living;Age;Angiography;autosome;Awareness;Binding;Biochemical;Biochemical Markers;Biological Markers;Birth;bone;Bone Density;Bone Diseases;Cardiopulmonary;Cartilage;Cervical;Characteristics;Child;Chondroitin Sulfate C;Clinic;Clinical;Clinical assessments;clinical candidate;clinical efficacy;clinical practice;clinical research site;Clinical Treatment;Clinical Trials;clinically relevant;Collaborations;Communities;Consumption;Data;Databases;Development;Diagnosis;Disease;Disease Progression;Distal;Dwarfism;Dysplasia;Effectiveness;Enrollment;enzyme replacement therapy;Enzymes;Equipment;Evaluation;exhaust;experience;Femur;Foundations;functional status;Future;Gait;gait examination;gene therapy;Glycosaminoglycan Degradation Pathway;Glycosaminoglycans;Goals;Growth;Health;Hearing;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hip region structure;Home;innovation;Institution;Interdisciplinary Study;interest;Intervention;Joint Laxity;Joints;Keratan Sulfate;Kyphosis deformity of spine;Lateral;Lead;Lesion;Life;Lung;Lung Capacity;Magnetic Resonance Imaging;Measurement;Measures;Medical;medical attention;Methods;Monitor;Motivation;Mucopolysaccharidoses;Mucopolysaccharidosis IV A;Natural History;Obstruction;Operative Surgical Procedures;Orthopedic Surgery;Osteotomy;Outcome;Outcome Measure;Pathogenesis;Patient Care;Patient Compliance;patient mobility;patient population;Patients;Pattern;Pharmacologic Substance;Phenotype;Physical assessment;physically handicapped;Physicians;Physiologic calcification;Physiologic Ossification;Placebo Effect;Postoperative Period;potential biomarker;predictive marker;Productivity;prognostic;Prognostic Marker;programs;Publications;pulmonary function;Pulmonary function tests;Questionnaires;reconstruction;Recording of previous events;Records;Registries;Research;research clinical testing;Research Personnel;Research Proposals;Respiratory Function Tests;response;risk stratification;Science;Severities;Severity of illness;Site;skeletal;skeletal abnormality;skeletal disorder;skeletal dysplasia;skeletal muscle weakness;Specialist;Specimen;stem cell therapy;Stenosis;Sulfatases;Sulfate;Surrogate Markers;System;Testing;Therapeutic;Therapeutic Intervention;therapy development;Time;Trachea;Training;Treatment Efficacy;Treatment outcome;treatment response;Visit;Walking;Wheelchairs

PROJECT_TITLE: Non-invasive functional assessment and pathogenesis of Morquio A

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE – OVERALL Our Center’s past activities have successfully advanced members’ capacity to renew and advance their science and obtain research funding, attracted new and diverse investigators to the Center, helped members establish themselves as leaders in environmental health science and public health, and connected investigators and communities. For the next funding period, CEHJNM will apply new scientific directions, increase services by restructuring facility cores, and advance community engagement and translational activities to address NIEHS’s strategic goals and respond to the most crucial public health needs of our times.

PI_NAMEs: PERZANOWSKI, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Academy;Address;Air Pollution;Articulation;Award;Awareness;Biological;Biometry;career;career development;Chemicals;climate change;climate-related health;Collaborations;Communication;Communities;community collaboration;community engagement;community partnership;Core Facility;Data;data management;Data Science;Dedications;Development;Doctor of Philosophy;early-career faculty;empowerment;environmental disparity;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Environmental Risk Factor;Exclusion;experience;Fostering;Funding;Future;Global Change;Goals;Grooming;Growth;Health;Health Sciences;Height;Inequity;Infrastructure;innovation;interest;Laboratories;Low income;member;Methods;Minority;Mission;Molecular;National Institute of Environmental Health Sciences;Neighborhoods;new technology;novel;organizational structure;Pilot Projects;Plastics;Principal Investigator;Program Development;programs;public database;Public Health;Research;Research Design;Research Personnel;Research Support;Sampling;School-Age Population;Science;Scientist;Services;social;Spottings;success;Technology;Time;Training;Training Programs;Translational Research;Translations;Universities;Vision;Washington;Water;Work;working group;Youth

PROJECT_TITLE: Center for Environmental Health and Justice in Northern Manhattan

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BACCARELLI, ANDREA  (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Award;Budgets;career;career development;Collaborations;college;Communication;community engagement;Community Health;Core Facility;design;Development;Disease;Doctor of Philosophy;early-career faculty;educational atmosphere;Educational workshop;Effectiveness;empowerment;environmental disparity;Environmental Exposure;Environmental Health;environmental justice;Evaluation;Event;Exclusion;Extramural Activities;Faculty;Fostering;Funding;Goals;Health;Heart;Inequity;interest;Leadership;leadership development;meetings;member;Mentors;Methods;Mission;National Institute of Environmental Health Sciences;Newsletter;operation;Physicians;Pilot Projects;Play;Positioning Attribute;prevent;Process;Productivity;Program Development;programs;Progress Reports;Public Health Schools;Recording of previous events;recruit;Research;Research Personnel;Resources;Role;Science;Scientist;Services;social media;Strategic vision;Structure;Surgeon;symposium;Time;Training;Translations;Universities;web site;working group

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The specific types and amounts of metabolite molecules present in biological systems, such as blood, serum, and tissues, provide critical information about health and disease. Metabolomics is a top-down approach, which involves identification and quantitation of metabolites in complex biological mixtures. The proposed research program aims at developing new metabolomics technologies, which are based on nuclear magnetic resonance (NMR) spectroscopy as well as in combination with cheminformatics and with mass spectrometry, to analyze a wide range of biological mixtures more comprehensively, accurately, and efficiently and to apply these tools and make them available to the scientific community, including via public web servers and databases, with synergistic benefits also for protein science.

PI_NAMEs: BRUSCHWEILER, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Biological;biological systems;Blood;Chemicals;cheminformatics;Communities;Complex;Databases;Diagnosis;Disease;Health;Human;Hybrids;Malignant Neoplasms;Mass Spectrum Analysis;metabolomics;Methodology;Methods;NMR Spectroscopy;novel strategies;Nuclear Magnetic Resonance;Nuclear Protein;programs;Proteins;Research;Science;Serum;spectroscopic data;synergism;Technology;Tissues;tool;Urine;user-friendly;web server

PROJECT_TITLE: Advanced NMR, computational, and hybrid methods for metabolomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Cost Effectiveness Research;Neurosciences;Prevention;Rare Diseases

PHR: Project Narrative Amyloidosis is an under-appreciated cause of lumbar spinal stenosis in older adults and proceeds the development of transthyretin cardiac amyloidosis by many years. By systematically evaluating older adults with lumbar spinal stenosis who have previously undergone lumbar spine surgery and evaluation of pathologic specimens for amyloid, and if amyloid is present, performing tissue typing with mass spectrometry, there's a unique opportunity to identify older adults with ATTR-CA early in the course of the illness, at a time when disease modifying therapies that are most effective. The data collected in the planned studies could change clinical practice and facilitate early identification of those who develop transthyretin cardiac amyloidosis, a disorder that without recognition and treatment is a progressive, highly morbid, and fatal but with early identification is easily managed.

PI_NAMEs: MAURER, MATHEW S (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Affect;Age;age related;Age Years;Aging;Amyloid;Amyloidosis;Artificial Intelligence;biceps brachii muscle;Bilateral;Body mass index;bone;Cardiac;cardiac amyloidosis;Carpal Tunnel Syndrome;Clinical;clinical practice;cohort;Congo Red;cost effective;cost-effectiveness evaluation;Data;Denmark;Deposition;Development;Diagnosis;Diphosphates;Disease;Early Diagnosis;Early identification;effective therapy;Evaluation;experience;Future;Genes;Grant;Hip region structure;Histocompatibility Testing;Histologic;improved outcome;Individual;Institution;Knee;ligamentum flavum;male;Mass Spectrum Analysis;Morbidity - disease rate;mortality;Mutation;Myocardial dysfunction;novel;Nuclear;nuclear imaging;older adult;Operative Surgical Procedures;Orthopedics;Outcome;Pathologic;Pathology;Patients;Population;Prealbumin;Prevalence;programs;Prospective, cohort study;Protein Precursors;Radionuclide Imaging;rare condition;Replacement Arthroplasty;Research Personnel;Risk;Sampling;screening;screening program;Shoulder;Specimen;Spinal;Spinal Stenosis;Spine surgery;Stains;Techniques;tendon rupture;Testing;Time;Tissues;United States;Variant;Vertebral column

PROJECT_TITLE: Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: NARRATIVE: The objective of this program is to train individuals to study the genetic and neurobiological basis of high alcohol-seeking and drinking behaviors. This field of research is important for developing treatment strategies for both the prevention and treatment of alcohol use disorders.

PI_NAMEs: CZACHOWSKI, CRISTINE L (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Alcoholism;Genetic;Grant;Training

PROJECT_TITLE: Training Grant on Genetic Aspects of Alcoholism


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

PI_NAMEs: CHILLRUD, STEVEN N. (contact)

PROJECT_TERMS: Address;Air;Allergens;analytical method;Animals;biobank;Biological;biomarker panel;Blood;Carbon;career;career development;Cell Culture Techniques;Clinical;Collaborations;Collection;Communities;community based participatory research;community engagement;community partners;Complement;Consult;Core Facility;cost;Data;Data Collection;Data Science;Databases;design;DNA Adducts;DNA Methylation;Doctor of Philosophy;Dust;Emergency Situation;empowerment;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;epigenomics;Equipment;Equity;Exposure to;fabrication;Faculty;Farm;Fostering;fungus;Genomics;Goals;Hair;Health;health determinants;Health Sciences;Health Services Accessibility;Human;Human Milk;improved;In Vitro;in vivo Model;Instruction;Interdisciplinary Study;Investigation;Isotopes;Laboratories;Lead;Link;Maintenance;Medical center;member;metabolomics;Metals;Methods;Monitor;next generation;Pilot Projects;Planet Earth;Population;population based;Postdoctoral Fellow;programs;Protocols documentation;Public Health;Radioisotopes;Recording of previous events;repository;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Saliva;sample archive;sample collection;Sampling;Scanning;sensor;Services;single cell sequencing;Soil;Source;student training;Students;success;Tissues;tool;Toxicology;Trace Elements;Trace metal;Training;Training Support;transcriptomics;Transition Elements;Translational Research;Universities;Untranslated RNA;Urine;Validation;Water;Work

PROJECT_TITLE: Translational Research Support Core


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Neurotoxicity occurs in Huntington’s disease and other polyglutamine disorders. Normalizing neuronal health has been suggested as a therapeutic strategy. This project investigates the role of a novel neuronal nuclear pathway, the sphingosine kinase 2 and zinc fingers and homeoboxes 2 pathway, in neuronal toxicity in wild-type neurons and in neurons that express mutant huntingtin, the protein that causes Huntington's disease.

PI_NAMEs: TSVETKOV, ANDREY  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Abbreviations;Animal Cancer Model;Animal Model;Anxiety Disorders;Apoptosis;behavioral outcome;Binding;Biochemical;Biological;blood-brain barrier crossing;Brain;Cell Nucleus;Cell Survival;Cells;Central Nervous System;Cessation of life;ChIP-seq;Cholesterol Homeostasis;cohort;Complex;Corpus striatum structure;Data;disability;Disease;disease phenotype;Disease Progression;drug discovery;Ectopic Expression;Female;field study;Genes;Genetic;Genetic Transcription;Health;Heat-Shock Response;Histone Deacetylase;Homeobox;Huntington Disease;Huntington gene;improved;Inclusion Bodies;Inflammation;inhibitor;Lead;Link;Lipids;male;Methods;Microscopy;Modeling;Molecular;Motor;motor symptom;mouse model;Mus;mutant;Neurodegenerative Disorders;neuronal survival;Neurons;Neuroprotective Agents;neurotoxicity;novel;novel therapeutic intervention;Nuclear;overexpression;Paper;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenocopy;polyglutamine;polyglutamine neurodegenerative diseases;Proteins;Psyche structure;Publishing;Rodent;Role;Rotarod Performance Test;Sampling;Sepsis;sex;Signal Pathway;Signal Transduction;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Symptoms;Testing;Therapeutic;therapeutic target;Toxic effect;transcription factor;Transcription Repressor;transcriptome sequencing;Zinc Fingers

PROJECT_TITLE: Nuclear sphingosine kinase 2 in Huntington disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: FACTOR-LITVAK, PAM R (contact)

PROJECT_TERMS: Address;Applied Research;Area;Artificial Intelligence;artificial intelligence method;Biological Markers;biomedical informatics;Biometry;Charge;Clinical;Code;Collaborations;Communities;Complex;complex data;computer infrastructure;Computerized Medical Record;Consultations;Core Facility;Data;Data Analyses;Data Analytics;data management;Data Science;data science education;data sharing;Data Sources;database design;design;Doctor of Philosophy;education resources;electronic medical record system;Ensure;environmental disparity;Environmental Engineering technology;Environmental Exposure;Environmental Health;environmental justice;Epidemiologist;Epidemiology;Faculty;Funding;Genomics;Goals;Health;high dimensionality;implementation study;Institution;Intervention Studies;Laboratories;large datasets;Leadership;Link;Machine Learning;Manuscripts;member;Methods;Mission;multiple omics;National Institute of Environmental Health Sciences;patient oriented;Pilot Projects;Population Research;Population Study;Postdoctoral Fellow;Programming Languages;programs;Public Health Schools;Recording of previous events;repository;Reproducibility;Research;Research Design;Research Personnel;Resources;Role;Services;Shamanism;sound;Statistical Data Interpretation;statistical learning;Statistical Models;Students;success;Surveys;Systems Biology;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Study Design and Data Science Facility Core


NIH_SPENDING_CATS: Clinical Research;Orphan Drug;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Immunoglobulin light chain amyloidosis (AL) is a degenerative disease that putatively arises from light chain misfolding and aggregation. AL patients, who suffer from both a plasma cell cancer and a LC misfolding and aggregation-associated proteinopathy, are often too sick to tolerate the currently available standard of care that targets the cancer component of AL. In this proposal, we seek to produce light chain kinetic stabilizer lead candidates that ameliorate the proteinopathy component of AL pathology, offering a mechanistically distinct drug candidate.

PI_NAMEs: KELLY, JEFFERY W (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Albumins;American;Amino Acids;Amyloidosis;analog;Aniline;base;Binding;Binding Sites;Biological Assay;Buffers;cancer cell;Cardiac;Cell secretion;Chemistry;Chemotherapy-Oncologic Procedure;Chromatography;Clinical Trials;Clonal Expansion;Computer software;computerized tools;Coumarins;Coupled;Data;Degenerative Disorder;design;Deterioration;Diagnosis;dimer;Dissociation;Disulfides;Docking;drug candidate;Endopeptidase K;experimental study;Family;Fluorescence Polarization;Human;improved;Kinetics;Label;Lead;lead candidate;Learning;Length;Light;Light-Chain Immunoglobulins;Link;Malignant Neoplasms;Medical;Metabolic;Molecular Conformation;molecular sequence database;monomer;Multiple Myeloma;Organ;Pathology;Patients;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plasma;Plasma Cells;Plasma Proteins;Population;Positioning Attribute;preservation;prevent;primary amyloidosis of light chain type;Process;Publishing;scaffold;screening;small molecule;standard of care;Structure;Structure-Activity Relationship;Therapeutic;Time;Variant;X-Ray Crystallography

PROJECT_TITLE: Probing the Proteinopathy Component of Light Chain Amyloidosis Pharmacologically

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE People experiencing homelessness (PEH) are at high risk for emergency department and hospital use due to gaps in care and poor communication between health and social services providers. This study will integrate and test a novel mHealth intervention, comprised of global positioning system technology and text messaging components, into a community setting in order to connect PEH with healthcare and social services. This research is significant in that it will engage end-users in refining and integrating the mHealth intervention with a community-based navigation center and employ a RCT design to test the impact of the intervention on ED and hospital visits and health and social needs outcomes.

PI_NAMEs: MOCZYGEMBA, LETICIA RAE (contact)

PROGRAM_OFFICER_NAME: HARDING, BRENDA

PROJECT_TITLE: mHealth Technology to Connect and Empower People Experiencing Homelessness to Improve Health and Social Need Outcomes

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

PI_NAMEs: ZOTA, AMI R (contact)

PROJECT_TERMS: Academic Training;Academy;Address;Advocate;Air Pollution;Area;Beauty;career;Chemical Exposure;cohort;Collaborations;college;Communication;Communities;community based research;community engaged research;community engagement;community organizations;community partners;Databases;design;Education;Ensure;Environmental Health;environmental justice;Equity;evidence base;experience;Fostering;Funding;Goals;Growth;health determinants;health disparity;health equity;health literacy;Housing;Infrastructure;innovation;interest;Intervention;Justice;Leadership;Learning;literacy;Lived experience;member;Methods;Multimedia;New York;New York City;outreach;podcast;Policies;Printing;project-based learning;public database;Public Health;Recording of previous events;Research;Research Methodology;Research Personnel;Resources;School-Age Population;Schools;Science;skills;social;social media;Societies;sociologist;STEM curriculum;Structure;Training;translational impact;translational potential;Translations;Universities;Voice;Work;Youth

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: CHAMPAIGN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE A wearable alcohol biosensor might serve health needs across a variety of domains, including aiding in the prevention of alcohol-related disorders, improving interventions for treating problem drinking, and refining outcome assessment in alcohol research. Transdermal sensors represent a uniquely noninvasive and low-cost method for the continuous assessment of alcohol consumption, but data produced by these sensors is highly complex. The current project leverages advances in transdermal technology and computational modeling to translate transdermal data and assess the accuracy of transdermal BAC estimates, thus taking a key step towards clarifying the place of transdermal sensors in our arsenal of techniques for assessing, preventing, and treating problem drinking.

PI_NAMEs: FAIRBAIRN, CATHARINE  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Abstinence;Accelerometer;addiction;Address;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol content;alcohol measurement;alcohol monitoring;alcohol prevention;alcohol research;Alcohol-Related Disorders;Alcoholic beverage heavy drinker;Alcoholic Intoxication;Alcohols;Algorithms;analytical method;Ankle;arm;Biosensor;Blood alcohol level measurement;Cellular Phone;Clinical;Cognitive;Complex;Computer Models;Consumption;contingency management;cost;Criminal Justice;Data;Data Analytics;Data Collection;deep neural network;Dependence;design;Development;Devices;Dose;drinking;Enrollment;Family;fitbit;Generations;Grain;Harm Reduction;Health;Human;human subject;improved;Individual;Influentials;interest;Intervention;Laboratories;Laboratory Research;Laboratory Study;large datasets;Left;Link;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Measures;Memory;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;Neural Network Simulation;novel;Outcome Assessment;Output;Participant;Patient Self-Report;Personal Satisfaction;Persons;Population;prevent;Prevention;Procedures;Race;Relapse;Research;Rest;Sampling;Science;Scientist;sensor;sex;Skin;Source;Specificity;Surface;Techniques;Technology;Temperature;Testing;Time;Translating;Translations;Uncertainty;wearable device;Work

PROJECT_TITLE: Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates from New-Generation Transdermal Technology using Large-Scale Human Testing and Machine Learning Algorithms

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RE, DIANE BERENGERE (contact)

PROJECT_TERMS: Academia;Applications Grants;Area;Award;Basic Science;Biological;career;Categories;climate-related health;Communication;Communities;community engagement;Core Facility;Creativeness;Data;Data Collection;Data Science;Development;Discipline;Doctor of Philosophy;early-career faculty;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Exclusion;Extramural Activities;Faculty;Fostering;Funding;Funding Mechanisms;Goals;Grant;Health;Height;Human;human study;Individual;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Laboratory Scientists;Leadership;Link;member;Molecular;National Institute of Environmental Health Sciences;New York City;novel;Pilot Projects;Population;Preparation;Process;programs;Publications;Recording of previous events;recruit;Research;research and development;Research Design;Research Personnel;Research Project Grants;Science;Scientist;success;Translational Research;Underrepresented Populations;Universities;Washington

PROJECT_TITLE: Pilot Project Program


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Cost Effectiveness Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Prevention;Social Determinants of Health

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative.  Given the likelihood of COVID-19 remaining an endemic disease among high-risk populations, establishing effective mitigation interventions will be critical to stemming community transmission. Criminal justice-involved individuals are extremely important to reducing community-based SARS-CoV-2 transmission due to their increased risk of contracting SARS-CoV-2 while incarcerated and their likelihood of living in congregate settings after incarceration. We will evaluate an onsite Point-of-Care SARS-CoV-2 testing and education strategy in a corrections-focused community-based organization and its impact on improving testing uptake, mitigation behaviors (e.g. mask wearing, hand hygiene, social distancing, vaccine uptake when available), and cost- effectiveness.

PI_NAMEs: AKIYAMA, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 2019-nCoV;academic standard;Accounting;Address;Adherence;Antigens;barrier to care;Behavior;Cellular Phone;Cessation of life;Client;Communities;Community Health Aides;community organizations;community transmission;comorbidity;compare effectiveness;comparison intervention;Contracts;Coronavirus;cost;Cost Analysis;cost effective;cost effectiveness;Cost Measures;Counseling;Coupled;COVID-19;COVID-19 point of care;COVID-19 testing;Criminal Justice;Data Sources;Disease Outbreaks;Dose;Economics;Education;Educational Intervention;Educational Status;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Endemic Diseases;Environment;experience;Face;Fortune;General Population;Goals;Halfway Houses;Hand;Healthcare;Hepatitis C;high risk;high risk population;HIV;homeless shelters;Homelessness;Housing;Hygiene;Illinois;Immunocompromised Host;Imprisonment;improved;Individual;Infection;Intervention;Jail;Justice;Lived experience;Low Prevalence;low socioeconomic status;markov model;Masks;Medical;Modeling;mortality;Needle-Exchange Programs;Needs Assessment;New York City;novel;Online Systems;Outcome;pandemic disease;Participant;people of color;Persons;Play;point of care;point of care testing;primary outcome;Prisons;programs;Public Health;Questionnaires;Randomized;randomized trial;Records;Risk;Risk Factors;Role;SARS-CoV-2 infection;SARS-CoV-2 transmission;secondary outcome;Services;Shelter facility;Site;social cognitive theory;Social Distance;Societies;standard of care;stem;supported housing;Surveys;Test Result;Testing;testing uptake;transmission process;United States;Vaccination;vaccine acceptance;ventilation;Vulnerable Populations

PROJECT_TITLE: Leveraging community health workers to improve SARS-CoV-2 testing and mitigation among criminal justice-involved individuals accessing a corrections-focused community-based organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Memory allows us to remember specific past experiences, but also find commonalities across experiences generalizable to novel situations. The proposed research will improve our understanding of mechanisms supporting memory specificity and generalization, their contribution to decision-making, and their implementation in the healthy brain. These findings will generate new predictions about the causes of a wide variety of memory impairments, such as reduced memory specificity in aging and Alzheimer’s disease, imbalance of specificity and generalization learning in anxiety, depression, and autism, and mixed patterns of impairments following a stroke.

PI_NAMEs: ZEITHAMOVA, DAGMAR  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Aging;Alzheimer's Disease;Anterior;Anxiety;autism spectrum disorder;Basic Science;Behavior;Behavioral;Brain;Categories;Cognition;Cognitive;Corpus striatum structure;Data;Decision Making;Episodic memory;Equilibrium;Event;experience;Functional Magnetic Resonance Imaging;Hippocampus;Human;Impairment;improved;indexing;Individual;Individual Differences;information organization;Judgment;Knowledge;Learning;Link;Measures;member;Memory;Memory impairment;Mental Depression;Methods;Modeling;Nature;neural;neural patterning;Neurologic;neuromechanism;neuropsychiatric disorder;Neurosciences;novel;Participant;Pattern;Recording of previous events;Research;response;Role;Specificity;stem;Stroke;Structure;System;Testing;theories;tool;Work

PROJECT_TITLE: Neural mechanisms of specificity and generalization learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: I am a clinical psychologist and researcher proposing a 5-year K23 project that includes research and a training program that will allow me to acquire the knowledge and skills I need to become an independent clinician-scientist. What I discover will offer novel data to aid the translation of a prevention model of Alzheimer's disease (AD) dementia from research into routine clinical practice. I will discover how subjective cognitive complaints (SCCs) and future time perspective (FTP) are affected by learning a biomarker result (SA#1), how associations between SCCs and underlying AD pathology are affected by knowledge of an AD biomarker (SA#2), and how changes in FTP in persons with knowledge of an AD biomarker correspond to decision-making (SA#3).

PI_NAMEs: STITES, SHANA D. (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Anxiety;Atrophic;Behavior;Biological Markers;Brain;Caring;Classification;Clinic;Clinical;clinical care;clinical practice;Cognitive;cognitive function;Cohort Studies;Communication;Data;Decision Making;Dementia;Diagnosis;Disclosure;discount;Disease;Disease Progression;Early Diagnosis;Education;Ensure;Evaluation;Event;evidence base;experience;Funding;Future;Gender;Geriatrics;Goals;Health;health related quality of life;imaging biomarker;Impaired cognition;Impairment;Individual;instructor;Intervention;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Learning;lifestyle intervention;Logic;Measures;medial temporal lobe;Memory;Mental Depression;Mentors;Modeling;multidisciplinary;Nerve Degeneration;Neurobehavioral Manifestations;neuroimaging;novel;older adult;Participant;participant enrollment;Patients;Pennsylvania;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Positron-Emission Tomography;pre-clinical;precision medicine;Prevention;Process;programs;psychologic;Psychological Models;Psychologist;Psychology;Questionnaires;Race;Reporting;Research;Research Methodology;Research Personnel;research to practice;Risk;routine practice;Scanning;Scientist;Series;Site;skills;tau Proteins;Time;Training;Training Programs;Translating;translational model;Translations;Universities;Waiting Lists;Work

PROJECT_TITLE: Study of Cognitive Symptoms and Future Time Perspective in Preclinical Alzheimer's Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Prosocial behaviors are central to the development of children and the functioning of households. This research will examine the role of reasoning in prosocial development during the preschool years, both how reasoning develops through caregiver-child conversations and how reasoning shapes children’s judgments and decisions about opportunities to help others. By better understanding the role of reasoning in early prosocial development, families and researchers may create everyday conditions that strengthen children’s healthy prosociality.

PI_NAMEs: CALLANAN, MAUREEN A (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 3 year old;6 year old;Accounting;adopted child;Area;Asian;Attention;Behavior;Black race;Caregivers;caregiving;Characteristics;Child;Child Development;Cognitive;Communities;constructivism;cost;design;Development;early childhood;Empathy;Equilibrium;ethnic diversity;Event;exhaustion;Family;Family Characteristics;Frequencies;Home;Home visitation;Household;Individual;Individual Differences;Infant;innovation;insight;interest;Intervention Studies;Interview;Judgment;Latinx;Lead;Methods;Modeling;Morals;novel;Nursery Schools;Parents;Persons;predictive modeling;Problem behavior;Procedures;Process;recruit;Reporting;Research;Research Personnel;response;Risk;Role;Sampling;San Francisco;Science;Shapes;Social Development;Social isolation;social relationships;Socialization;Structure;Surveys;Testing;Theoretical model;Toddler;Variant;virtual;Work

PROJECT_TITLE: How reasoning contributes to preschoolers’ prosocial development

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research;Youth Violence

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Adolescent-onset substance use disorders are linked to poorer psychosocial outcomes and are predictive of mortality in early adulthood. For this reason, it is important to identify social and environmental factors that increase an adolescent’s risk of using substances and address those factors in clinical guidance and treatment planning. This study proposes the use of digital phenotyping technology to examine the complex and growing influence of digital media, including online exposure to substance-related content, on adolescent use and procurement of drugs and alcohol.

PI_NAMEs: GANSNER, MEREDITH  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 18 year old;Address;Adolescent;adolescent alcohol and drug use;adolescent drug use;adolescent substance use;Advertisements;Age;aged;Alcohol consumption;Alcohols;Anxiety;Behavioral;Categories;Cellular Phone;Clinical;Communication;Communities;Complex;Cross-Sectional Studies;cyberbullying;Data;design;digital;digital media;digital phenotyping;digital platform;Distress;Drug Experimentation;Drug Prescriptions;Drug usage;emerging adult;Emotions;Environmental Risk Factor;Epidemiology;ethnic minority;experience;Exposure to;Gender;Goals;Heterogeneity;high risk;high-risk adolescents;improved;Individual;Internet;Intervention;Language;life span;Link;longitudinal analysis;Longitudinal Studies;media use;Mental Depression;Methodology;minority children;Mission;mortality;National Institute of Drug Abuse;novel;overdose death;Participant;Pathway interactions;peer;Personal Communication;Pharmaceutical Preparations;Prevention strategy;Protocols documentation;psychiatric symptom;Psychosocial Factor;psychosocial outcome;Questionnaires;racial minority;racism;Recording of previous events;Reporting;Research;Research Personnel;Risk;Role;Sampling;Secondary to;Self Disclosure;sensor;smartphone application;social;social factors;social media;Statistical Methods;substance use;Substance Use Disorder;Survey Methodology;Surveys;Technology;Teenagers;Time;tool;Training;Training Programs;treatment planning;Victimization;Visualization;Youth

PROJECT_TITLE: Use of Digital Phenotyping to Understand Digital Media Influence on Adolescent Substance Use

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Cardiac rehabilitation (CR) is purported to improve cardiovascular function, outcomes, and health care utilization after cardiac surgery, but (I) is used variably across patients, providers, and regions, (ii) lacks of substantial and robust evidence for benefit, and (iii) is often the target of financial incentive programs. The proposed research will shed new light on the determinants of CR enrollment after cardiac surgery, the effect of CR enrollment on clinical and economic outcomes, and impact of financial incentives on CR enrollment and subsequent outcomes. The result of this project will provide the evidence needed to develop effective programs and policies designed to improve CR enrollment after cardiac surgery, which will increase the value of cardiac surgical care.

PI_NAMEs: THOMPSON, MICHAEL PATRICK (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Determinants, Outcomes, and Financial Incentives Associated with Cardiac Rehabilitation Enrollment After Cardiac Surgery

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Osteoarthritis (OA) is a common medical problem for US Veterans. More than 30% of Veterans in the VA healthcare system have OA, higher than in the general population in the US. OA is often painful, and leads to poor quality of life, making it hard to lead a fully functional life, and when it progresses, can be debilitating. Drugs prescribed to alleviate joint pain and joint replacement are the only effective treatments. However, joint replacement surgeries are expensive and even after surgery and rehabilitation, many Veterans still do not regain significant improvements in quality of life, have difficulties performing regular daily activities, need additional care and are more likely to be hospitalized. OA has a genetic component. Therefore, there is a potential to provide insight to why some Veterans develop OA and why some progress to end-stage disease with limited recovery to joint replacement surgery. We propose to follow-up our previous work where genetic analyses led to discoveries with striking potential for translation to clinical care, i.e. findings that will be meaningful to Veterans with OA.

PI_NAMEs: MCDONALD DONNELLY, MERRY-LYNN NOELLE (contact)

PROJECT_TERMS: Activities of Daily Living;Adverse event;adverse outcome;African American;African American population;American;ancestry analysis;Area;Arthralgia;Asian population;biobank;Biological Markers;biomarker identification;Caring;clinical care;Code;cohort;Collaborations;comorbidity;cost;Data;Degenerative polyarthritis;Development;Diagnosis;Drug Prescriptions;East Asian;Economic Burden;effective therapy;Electronic Health Record;end stage disease;Etiology;European;evidence base;experience;Exposure to;Failure;follow-up;Frequencies;functional restoration;General Population;Genetic;genetic analysis;Genetic Determinism;genetic variant;Genetic Variation;genome wide association study;genomic biomarker;Genomics;Goals;Habilitation;health care service utilization;health related quality of life;Healthcare Systems;Heritability;Hip region structure;hip replacement arthroplasty;Hispanic;Hospitalization;improved;improved mobility;Incidence;Individual;insight;Intuition;Knee;Knee joint;knee replacement arthroplasty;Knowledge;Life;Life Style;Manuscripts;Medical;military veteran;novel;Occupational;Operative Surgical Procedures;Outcome;Pain;Pain management;Participant;patient oriented;patient prognosis;Patient-Focused Outcomes;Patients;Performance;personalized approach;Phase;Physicians;polygenic risk score;Population;Population Heterogeneity;precision medicine;predictive modeling;Preparation;Prevalence;primary outcome;prognostic;programs;progression risk;Quality of life;Questionnaires;Recovery;recruit;rehabilitation strategy;Rehabilitation therapy;Replacement Arthroplasty;Research;response;Risk Factors;risk stratification;Sample Size;Scoring Method;secondary analysis;secondary outcome;success;Surveys;symptom management;Testing;therapeutically effective;Training;translational potential;Trauma;Traumatic Arthropathy;Treatment Cost;United States;Variant;Veterans;Work

PROJECT_TITLE: Genetics of Osteoarthritis and Joint Replacement Recovery: Key to Precision Rehabilitation

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Natural Products;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE:  This project aims to develop novel botulism therapeutics based on the use of natural neuronal receptors and trafficking patterns normally employed by the targeted toxin itself. Unlike available antibody-based therapeutics and small molecule inhibitors of the light chain metalloprotease, botulism therapeutics based on atoxic derivatives of botulinum neurotoxin (BoNT) can reach an intracellular target in a post‐exposure setting. In addition, unlike conventional, small molecule therapeutics which would equally affect all cells in the body with potentially deleterious cytotoxic side effects, the proposed atoxic BoNT-based molecular vehicle will specifically deliver a therapeutic moiety only to the cytosol of the target cells (motor neurons). This is a unique and innovative approach toward treating not only botulism, as embodied in this proposal, but also toward treating numerous infectious and neurodegenerative diseases in which therapeutic targets reside and exert their action intracellularly.

PI_NAMEs: ICHTCHENKO, KONSTANTIN  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acceleration;acute toxicity;Affect;Affinity;Animal Testing;anti-toxin;Antibody Therapy;Antidotes;Binding;botulinum;botulinum toxin treatment;Botulinum Toxins;Botulism;Budgets;California;Cavia;Cells;Cessation of life;Chimeric Proteins;Clinical;Collaborations;Communicable Diseases;Cytoplasm;Cytosol;cytotoxic;Data;delivery vehicle;Development;Disease;Disease Outbreaks;Event;experience;Exposure to;FDA approved;Goals;Human;Immunoglobulin Therapy;improved;In Vitro;in vitro testing;in vivo;in vivo Model;Induction of neuromuscular blockade;innovation;Intoxication;lead candidate;Light;medical schools;Metalloproteases;Methods;Molecular;Motor Neurons;Mus;mutant;nanobodies;Nerve;Neurodegenerative Disorders;neuromuscular transmission;Neurons;neurotransmitter release;New York;next generation;nonhuman primate;novel;novel therapeutic intervention;Paralysed;Pathogenicity;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Pharmacology;Physiological;Poison;Poisoning;pre-clinical;presynaptic;prevent;Production;Property;Prophylactic treatment;Proteins;public health priorities;Qualifying;receptor;Recording of previous events;Recovery;Regenerative Medicine;Research Personnel;respiratory;Respiratory Paralysis;Role;Scientist;Serotyping;side effect;small molecule inhibitor;small molecule therapeutics;SNAP receptor;Specificity;Speed;success;Supportive care;symptom treatment;Symptoms;System;Systems Development;targeted delivery;Targeted Toxins;Testing;Therapeutic;therapeutic development;Therapeutic Index;therapeutic protein;therapeutic target;therapeutically effective;Toxic effect;Toxicology;trafficking;Treatment Efficacy;treatment strategy;ubiquitin ligase;United States;Universities;ventilation;Veterinary Medicine;Veterinary Schools

PROJECT_TITLE: Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]