ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Genetic variants are typically transmitted from the parents to their offspring, but they can also arise after conception (post-zygotically acquired) during embryonic development. Genetic variants in SLC35A2 arising during brain development have recently been implicated in intractable focal epilepsy. In this study, we seek to: (1) determine the brain cell types involved in SLC35A2 epilepsy, (2) study effects of the variants on neuronal glycosylation, neuronal development, and neuronal activity, and (3) assess the ability of galactose supplementation to reverse the deleterious effects of the variants on neurons.

PI_NAMEs: CRINO, PETER B;HEINZEN, ERIN L (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 3-Dimensional;Adult;Age of Onset;Alleles;Astrocytes;Biological Assay;Brain;brain cell;brain dysfunction;brain tissue;Cell Fraction;Cell Line;Cell Nucleus;Cell Separation;cell type;Cells;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complementary DNA;Conceptions;Congenital disorders of glycosylation;Cortical Dysplasia;Cortical Malformation;Coupled;CRISPR/Cas technology;Data;de novo mutation;Defect;Dendritic Spines;Development;Disease;druggable target;early onset;effectiveness evaluation;Electroencephalography;Electrophysiology (science);Electroporation;Embryonic Development;Epilepsy;epileptic encephalopathies;Event;FDA approved;fetal;Freezing;Functional disorder;Galactose;Genes;genetic variant;Genotype;Germ Lines;Germ-Line Mutation;girls;Glutamates;Glycoconjugates;Glycosphingolipids;glycosylation;Golgi Apparatus;Guide RNA;hemimegalencephaly;Human;human induced pluripotent stem cells;in utero;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insertion/deletion mutation;Intellectual impairment;Intractable Epilepsy;Kinetics;Knock-out;Length;Link;Lipids;Liquid Chromatography;loss of function;Mass Spectrum Analysis;Metabolic Diseases;Microscopy;migration;Modeling;Molecular;Monitor;Morphology;mosaic;mosaic loss;Mosaicism;mouse model;mRNA Expression;multi-electrode arrays;Mus;mutant;Mutation;neocortical;nerve stem cell;neural;neural network;Neurites;neurodevelopment;neurogenesis;neuron development;neuronal cell body;Neurons;novel;offspring;Oligodendroglia;Organoids;Parents;Partial Epilepsies;patch clamp;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Polysaccharides;Population;precision medicine;prevent;Process;Production;Protein Glycosylation;protein transport;Proteoglycan;radiological imaging;Refractory;Resected;Role;Sampling;Scanning;Seizures;Series;Severities;Severity of illness;single nucleus RNA-sequencing;Somatic Mutation;Specimen;stem cell organoids;Supplementation;Syndrome;Therapeutic;Time;Transferase;Translating;transmission process;Uridine Diphosphate Galactose;Variant;Western Blotting;Work;X Chromosome

PROJECT_TITLE: Defining disease mechanisms in SLC35A2 epilepsy


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE. Microsporidia, pathogenic protists related to Fungi (Cryptomycota), are oportunistic pathogens in humans, particularly in patients with AIDS. They invade cells using a unique mechanism. Studies of the polar tube, a structure involved in invasion, and the mechanism by whcih microsporidia invade their host cells should help define new stragtegies for the management of these emerging pathogens.

PI_NAMEs: WEISS, LOUIS M. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Agriculture;Animals;Antibodies;Aquaculture;Benign;Bioinformatics;Biological;Birds;Category B pathogen;Cell membrane;Cells;Cellular biology;Cessation of life;Chronic diarrhea;Classification;Collaborations;Comparative Study;Complement;Complex;Conjunctivitis;Cryoelectron Microscopy;Data;Development;Diarrhea;economic impact;Economics;emerging pathogen;Encephalitis;Encephalitozoon hellem;Enterocytozoon bieneusi;Epitopes;Etiology;experimental study;Fishes;Food;fungus;gastrointestinal;gene function;Genetic;Genome;genome resource;Germination;Grant;HIV;HIV Infections;Human;Human Genome;human pathogen;Immune;Immune Sera;Immunization;Immunocompetent;Immunocompromised Host;Immunoelectron Microscopy;Immunologics;immunomodulatory therapies;In Vitro;Infection;infection management;Insecta;insight;interest;Invaded;Invertebrates;Investigation;Keratoconjunctivitis;Laboratories;Laboratory Research;Mammals;Methods;Microbe;Microscopic;Microscopy;Microsporidia;Microsporidiosis;Molecular;Morphology;Mus;Muscle;Myositis;Nematoda;Nervous System;Nosema;Nosema corneum;novel therapeutic intervention;opportunistic pathogen;Organ Transplantation;Organelles;Organism;parasite invasion;pathogen;Pathogenesis;Pathogenicity;Patients;Penetration;Phylogenetic Analysis;Post-Translational Protein Processing;preservation;Process;programs;Proteins;Proteome;Proteomics;public health relevance;Publishing;Recombinants;Reproduction spores;reproductive;Research;Research Project Grants;respiratory;Role;sample fixation;Scanning Electron Microscopy;Septata intestinalis;Sister;Site;Soil;Source;structural biology;Structure;sugar;superresolution microscopy;Synapses;System;Techniques;TFRC gene;three dimensional structure;tool;Transfection;transmission process;Tube;United States National Institutes of Health;Validation;Vero Cells;wasting;Water

PROJECT_TITLE: Microsporidia: invasion apparatus

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Substance use is a major public health concern that disproportionately affects individuals from low socioeconomic status (SES) backgrounds. The proposed project will use data from three population- representative, longitudinal cohort studies to test both (a) whether one mechanism linking childhood socioeconomic status and problematic substance use is individual differences in distributed neural networks underlying different aspects of self-regulation and (b) whether these associations generalize across different racial/ethnic groups. Identifying these mechanisms will guide needed prevention and intervention efforts.

PI_NAMEs: SCHAEFER, JONATHAN DREW (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Alcohol abuse;alcohol related consequences;Alcohols;behavior influence;Behavioral;behavioral health;Berry;Brain;brain based;brain circuitry;Cannabis;Categories;Child;Child Development;Childhood;cognitive control;cognitive development;cohort;COVID-19 pandemic;Data;deprivation;Development;Disadvantaged;Emotional;Environment;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Family;Family Research;Frequencies;genome wide association study;Goals;Guide prevention;Health;Health Disparities Research;health disparity;Illicit Drugs;Income;indexing;Individual;Individual Differences;Inequality;Informal Social Control;Intercept;Intervention;Investigation;K-Series Research Career Programs;Life;Link;Longitudinal cohort study;low socioeconomic status;marginalization;Measurement;Measures;Mediating;Mediation;Mediator;Mentors;Minnesota;minority children;Modeling;morphometry;multimodality;National Institute of Drug Abuse;Nature;Neighborhoods;neural;neural network;neurobehavioral;neuroimaging;Nicotine;novel;Outcome;Participant;Pathway interactions;Pattern;Pharmaceutical Preparations;Policies;polygenic risk score;Population;Poverty;preadolescence;Prevention;prospective;Psychosocial Factor;Public Health;Race;racial difference;racial disparity;racial minority;racial population;Research;Research Support;Resources;Rest;reward processing;Rewards;Risk;Risk Factors;Sampling;Scientist;Skin;social;social disparities;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;stressor;Structure;Substance Addiction;substance use;Techniques;Testing;theories;tool;Training;Twin Multiple Birth;Work;Youth

PROJECT_TITLE: Using polyneuro risk scores to understand the relationship between childhood socioeconomic disadvantage, neurobehavioral deviations, and problematic substance use

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The Yale Diabetes Research Center provides the scientific infrastructure to support a wide spectrum of clinical and basic scientists who are working to better understand the factors driving the development of diabetes and to facilitate the translation of discoveries from the bench to the bedside that lead to new strategies for the treatment of individuals with, or who are at risk for developing diabetes.

PI_NAMEs: HEROLD, KEVAN C;SHULMAN, GERALD I (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Animal Model;Appointment;Area;Automobile Driving;base;Basic Science;bench to bedside;Bioinformatics;Biological;catalyst;Cells;Cellular biology;Clinical;Clinical Investigator;Clinical Research;Collaborations;college;Communities;Consumption;Core Facility;cost;cost efficient;design;Development;Diabetes Mellitus;Diabetes prevention;diabetic patient;disorder prevention;Education and Outreach;Environment;Fostering;Funding;Generations;Goals;Home;Human;human disease;human subject;improved;Individual;Infrastructure;innovation;interdisciplinary collaboration;interest;Investigation;Investments;Laboratories;meetings;member;Metabolic;Metabolic Diseases;Metabolism;metabolomics;microbial;Minority Groups;Mission;Molecular Biology;Molecular Genetics;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;novel;novel therapeutic intervention;Organizational Efficiency;Outcome;outreach;Participant;Pathogenesis;Patients;Peer Review;Physiology;Productivity;programs;Research;Research Activity;Research Personnel;Resources;Risk;Schools;Science;Scientist;Services;success;supportive environment;Talents;Techniques;Technology;Testing;Time;tool;Training;Training Programs;Translating;Translational Research;translational scientist;Translations;underserved minority;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Yale Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: SHULMAN, GERALD I (contact)

PROJECT_TERMS: Academia;Address;Animal Model;Area;Basic Science;bench to bedside;Biological;catalyst;Cellular biology;Clinical;Clinical Investigator;college;Consumption;Core Facility;cost;Data;design;Development;Diabetes Mellitus;diabetic patient;Discipline;doctoral student;Ensure;Environment;Expenditure;Faculty;Funding;Future;Goals;Grant;Health Occupations;High School Student;Human Subject Research;Inequity;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;Internships;medical schools;member;Metabolic;Metabolic Diseases;Metabolism;Mission;Molecular Biology;Molecular Genetics;multidisciplinary;Mus;novel;novel therapeutic intervention;Occupational activity of managing finances;Office of Administrative Management;operation;Organizational Efficiency;Outcome;outreach;Pathogenesis;Pathway interactions;Patients;Physiology;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention strategy;Productivity;programs;Publications;Reporting;Research;Research Activity;Research Personnel;Research Support;Research Training;Resources;Scholars Program;Schools;Science;Scientist;Services;student training;Suggestion;Supervision;Techniques;Testing;Time;tool;Training;Translating;Translational Research;United States National Institutes of Health;Vertebrates;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Stress is a major risk factor for mental health problems and has been strongly linked with the development of anhedonic symptoms (i.e. “stress-induced anhedonia”), however, the mechanisms by which stress leads to anhedonia are not fully understood. The goal of this K01 proposal is to explore the independent and additive contributions of mPFC glutamate function and inflammatory cytokines to stress-induced anhedonia. Elucidating these pathways will inform new targets for the treatment of anhedonia.

PI_NAMEs: ROBINSON, JESSICA COOPER (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: acute stress;Address;Anhedonia;Behavioral;Belief;Biological;Bipolar Disorder;career;Chronic;cytokine;Dendrites;density;Development;Diagnostic;disability risk;Ecological momentary assessment;Ensure;Etiology;excitotoxicity;Exhibits;expectation;experience;Exposure to;Failure;Female;Functional impairment;Future;Glutamates;Goals;Heterogeneity;Human;Immune response;Individual;Individual Differences;Inflammation;Inflammatory;inflammatory marker;insight;Interleukin-6;Intervention;Joints;Life;Link;Magnetic Resonance;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Medial;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Modeling;National Institute of Mental Health;neural;neurobiological mechanism;Neurobiology;Outcome;Participant;Pathway interactions;Patients;perceived stress;Peripheral;Pharmacological Treatment;Plasma;preclinical study;Prefrontal Cortex;psychosocial;Quality of life;recruit;Research;Research Domain Criteria;response;Rewards;Risk Factors;Sampling;Schizophrenia;Severities;Spectrum Analysis;Stress;stressor;suicidal;suicidal risk;Symptoms;Synapses;Testing;TNF gene;Translating;Treatment outcome;Ventral Striatum;Vertebral column;Work

PROJECT_TITLE: From stress to anhedonia: examining inflammation and altered glutamate function as distinct or common etiological pathways

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: We discovered that anticoagulant Protein S (PS) inhibits FIXa. Here, we will identify the region of PS that binds and inhibits FIXa. Precise definition of the binding site of FIXa on PS may enable us to make a polypeptide mimetic of PS to treat individuals with PS deficiencies.

PI_NAMEs: MAJUMDER, RINKU  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: activated Protein C;Acute;Affinity;Amino Acids;Antibodies;Anticoagulants;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Blood coagulation;Blood Platelets;Blood Vessels;Calorimetry;Chimera organism;Coagulation Process;cofactor;Deep Vein Thrombosis;Development;Docking;EGF gene;Electrostatics;experimental study;Factor IXa;Fibrin;Fluorescence Anisotropy;fluorescence imaging;Functional disorder;Funding;Goals;Hemorrhage;Hemostatic function;Heparin Binding;in silico;In Vitro;in vivo;Individual;Infusion procedures;inhibitor;Knowledge;Label;Laminin;laminin S;Life;macromolecule;Maintenance;Measures;Mediating;mimetics;Modeling;Molecular;Molecular Conformation;Mus;mutant;Mutate;Mutation;Neonatal Thrombocytopenia;novel;Pathology;Plasma;Plasma Proteins;polypeptide;Property;Protease Domain;Protein C Inhibitor;protein function;Protein Region;Protein S;Protein S Deficiency;Proteins;Pulmonary Embolism;Purpura Fulminans;response;restoration;Saphenous Vein;Site;Stroke;Tertiary Protein Structure;Testing;TFPI;Thrombin;Thrombosis;thrombotic;Titrations;United States National Institutes of Health;Up-Regulation;Venous Thrombosis

PROJECT_TITLE: Protein S Regulates Blood Coagulation by Inhibiting Factor IXa

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Bioengineering;Diabetes;Nutrition

PROJECT_TERMS: Amino Acids;Animals;Automation;Biopsy;Calibration;Carbohydrates;Carbon;Cell model;Child;child bearing;Citric Acid Cycle;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Complex;Complications of Diabetes Mellitus;Core Facility;cost;Data Analyses;Derivation procedure;design;Diabetes Mellitus;Engineering;Ensure;experience;experimental study;Fee-for-Service Plans;Frequencies;Goals;Human;human disease;human model;Human Resources;impaired glucose tolerance;in vivo;instrument;instrumentation;Insulin Resistance;Ionizing radiation;isotope incorporation;Isotopes;Kinetics;Laboratories;Lipids;liquid chromatography mass spectrometry;Longitudinal Studies;Maintenance;Mass Fragmentography;Measurement;Measures;member;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Modeling;Modernization;Molecular;Multinuclear NMR;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;operation;Pathway interactions;patient oriented research;patient population;Patients;Plasma;Progress Reports;Proteins;Protocols documentation;Quality Control;Radioisotopes;Rattus;Research;Research Activity;Research Personnel;research study;Resources;response;Rodent Model;Sampling;skills;stable isotope;Stable Isotope Labeling;Standardization;Time;Tissue Sample;Tissues;Tracer;Training;type I and type II diabetes;Urine;Woman;Work

PROJECT_TITLE: Clinical Metabolism Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Cells must fold and organize the DNA in their nucleus. Most cells follow the same basic rules for organizing their DNA, but a few types of cells have been shown to bend these rules in order to organize their DNA in new and distinctive ways that serve specific functions. In order to understand when and how this happens, we will study the specialized 3D DNA structures that form in mouse olfactory neurons and in mouse spinal cord.

PI_NAMEs: MONAHAN, KEVIN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Architecture;Cell Nucleus;cell type;Cells;Chromosomes;DNA;DNA Structure;Eukaryotic Cell;fascinate;Genes;Genome;Genomics;Mammalian Cell;Methods;Microscopy;Molecular;Mus;Nervous System;Neurons;Nuclear;Nuclear Structure;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;postmitotic;Receptor Gene;Regulation;response;Smell Perception;Spinal Cord;Stimulus;Structure;Time;Work

PROJECT_TITLE: Molecular basis and function of specialized nuclear structures in mouse neurons

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MCGILL UNIVERSITY

ORG_STATE: QC

ORG_ZIPCODE: H3A 0G4

PHR: Project Narrative (Spreng/Bzdok, McGill University) ! PROJECT NARRATIVE Loneliness in older adulthood is associated with cognitive decline and more rapid onset of Alzheimer's disease (AD), increasing burdens on the individual, caregivers, and the healthcare system. How loneliness impacts brain structure and function in later life, and whether it precedes or promotes accelerated neurodegeneration and the emergence of AD, is unknown. The proposed research will investigate how loneliness, a modifiable risk factor for AD, impacts the brain in normal aging and pre-symptomatic AD, towards the longer term goal of better surveillance and intervention. ! !1

PI_NAMEs: BZDOK, DANILO ;SPRENG, ROBERT NATHAN  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Address;Adopted;Age;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Behavioral;behavioral response;biobank;Brain;Brain Diseases;brain health;Caregivers;Cognitive;cognitive ability;Cognitive aging;cohort;Collaborations;Collection;Data;Data Collection;Data Set;Death Rate;Dementia;dementia risk;demographics;Detection;Disease;Disease Progression;Elderly;Epidemic;Evaluation;experience;Feeling;Goals;Healthcare Systems;human old age (65+);Impaired cognition;Individual;innovation;insight;Intervention;Laboratories;late life;Learning;Link;Loneliness;lonely individuals;Longitudinal cohort;Longitudinal Studies;Measurement;Methods;Modeling;modifiable risk;Monitor;Nature;Nerve Degeneration;neural;Neurobiology;neuroimaging;neuromechanism;neuropathology;Neurosciences;normal aging;novel;older adult;Older Population;Outcome;Participant;Pattern;Phenotype;Policies;poor health outcome;Population;pre-clinical;psychologic;Public Health;public health priorities;Reporting;Research;Research Design;Resolution;response;retiree;Risk;Role;Sample Size;Sampling;Scheme;Series;Shapes;Signal Transduction;social;Social Conditions;Social isolation;Structure;System;Testing;Universities;Work;World Health Organization;young adult

PROJECT_TITLE: Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progression

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: RICHMOND

ORG_DEPT: CHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Modified Public Health Relevance Section PROJECT NARRATIVE. The proposed research aims to build the first stages new technology with the potential to dramatically enhance the discovery of drugs that bind to and block interacting proteins associated with disease.  The technology involves expanding the genetic code to enable the creation of large collections of molecules from which potential drugs can be found.

PI_NAMEs: HARTMAN, MATTHEW C (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Affinity;Amino Acids;Amino Acyl Transfer RNA;Amino Acyl-tRNA Synthetases;base;Base Pairing;Binding;Biological Assay;Biological Availability;Catalogs;Charge;Code;Codon Nucleotides;Collection;Couples;Development;Disease;Diversity Library;drug discovery;Escherichia coli;experience;experimental study;falls;Future;Genetic Code;genetic manipulation;Goals;Guidelines;Hydrogen Bonding;In Vitro;Individual;inhibitor;Libraries;member;Messenger RNA;Methods;monomer;new technology;Oligonucleotides;Oral;Peptide Library;Peptides;peptidomimetics;Pharmaceutical Preparations;Positioning Attribute;preference;protein protein interaction;Proteins;public health relevance;Randomized;Reading;Refractory;Relaxation;Research;Sense Codon;small molecule;Source;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;success;Surface;System;Techniques;Technology;Terminator Codon;Testing;Time;Transfer RNA;translation assay;Translations;Variant

PROJECT_TITLE: Genetic code expansion for the construction of beyond rule-of-5 compliant macrocyclic peptide libraries

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The Training Program in Substance Use Disorders provides rigorous training in basic and translational research in substance use disorders for late-stage predoctoral and early-stage postdoctoral trainees through an integrated program of coursework, mentoring, training activities, teaching opportunities, and career development to prepare talented trainees for independent research careers in substance use disorders at all levels – from preclinical genetics, cellular and molecular mechanisms of the disorders, to clinical research and interventions.

PI_NAMEs: KENNY, PAUL J. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Substance Use Disorder;Training Programs


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Microbiome;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: FLAVELL, RICHARD A (contact)

PROJECT_TERMS: Ablation;Animal Model;Apolipoproteins;Area;Autoimmunity;Base Pairing;Binding Proteins;Biological Models;Biology;blood glucose regulation;Caspase;catalyst;CD34 gene;Cell Line;Chromosome Mapping;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;conditional knockout;Consultations;Consumption;Core Facility;cost;CRISPR/Cas technology;design;Development;Diabetes Mellitus;Disease;Dissection;embryonic stem cell;Engraftment;Ensure;Environment;Equipment;Exons;Experimental Designs;Family;Fostering;Funding;Gene Activation;Gene Expression;Gene Modified;gene replacement;Gene Targeting;Gene Transfer Techniques;Generations;Genes;Genetic;Genetic Recombination;Genetically Modified Animals;Genotype;Goals;guanylate;gut microbiota;Hematopoietic System;Human;human disease;human stem cells;humanized mouse;Immune response;Immune system;immunodeficiency;Immunologic Tests;Immunologics;improved;Inbred BALB C Mice;Infection;Inflammasome;Inflammation;Innate Immune System;innovation;innovative technologies;Insulin Receptor;Insulin-Dependent Diabetes Mellitus;interdisciplinary collaboration;interest;Interleukins;Intervention;Investigation;Investments;Knock-out;Knockout Mice;Laboratories;Lymphoid;Metabolic;metabolic abnormality assessment;Metabolic syndrome;Methods;microbiota;Mission;Modeling;Modification;Molecular;Molecular Genetics;Mouse Cell Line;mouse genome;mouse model;Mouse Strains;Mus;mutant mouse model;Mutation;Myelogenous;Nature;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organizational Efficiency;Peer Review;preservation;Productivity;programs;Quantitative Reverse Transcriptase PCR;receptor;Receptor Signaling;reconstitution;Recovery;Regulation;Reporter;Research;Research Personnel;Resources;response;Role;Scientist;Services;sperm cryopreservation;stem cell engraftment;Study models;System;Techniques;Technology;technology development;Testing;Time;Toll-like receptors;tool;Training;Translations;tumor;type I and type II diabetes;Work

PROJECT_TITLE: Molecular Genetics Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Microbiome;Nutrition;Obesity;Precision Medicine;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: NARRATIVE Microbes influence immunosurveillance as well as the efficacy of chemotherapy and immunotherapy that shape cancer outcomes, but underlying mechanisms remain unclear. Microbes themselves or metabolites derived by bacterial metabolism may be the mediating factors that alter the tumor microenvironment to impact anti-tumor immunity. Upon conclusion, this study will determine whether microbial-modification of bile acid pools and activation of bile acid receptor signaling act as novel mechanisms that can be leveraged to enhance anti-tumor immunity to improve patient outcomes in triple negative breast cancer.

PI_NAMEs: MAKOWSKI-HAYES, LIZA  (contact);PIERRE, JOSEPH F

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 7alpha hydroxylase;Ablation;absorption;Address;Adjuvant;Affect;Aggressive behavior;Agonist;Antibiotics;bacterial metabolism;bariatric surgery;Bile Acid Biosynthesis Pathway;Bile Acids;Blood Circulation;Body Weight decreased;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;cancer immunotherapy;cancer subtypes;carcinogenicity;Cell Communication;Cells;chemotherapy;Clinical;commensal microbes;Data;Dietary Intervention;Enterohepatic Circulation;Estrogen Receptors;experimental study;farnesoid X-activated receptor;fecal transplantation;gain of function;Generations;Genetic;Goals;Growth;gut microbes;gut microbiome;host microbiota;Human;Hydroxylation;Immune;Immune checkpoint inhibitor;Immunologic Surveillance;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Implant;improved;In Vitro;Incidence;innovation;Intestinal Neoplasms;Intestines;Invaded;Knowledge;Link;Liver;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediating;Mediator;Metabolic;Microbe;microbial;microbial community;microbial composition;microbiome;microbiome alteration;microbiome research;microbiota;migration;mimetics;Modeling;Modification;Mus;Neoplasm Metastasis;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;obese patients;Obesity;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;pharmacologic;Physiological;Play;precision medicine;Primary carcinoma of the liver cells;Proliferating;Race;receptor;receptor expression;Receptor Signaling;Relapse;Reporting;response;Role;Sampling;Secondary to;Shapes;Signal Transduction;small molecule;Stromal Cells;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;Tumor Markers;tumor microenvironment;tumor progression;Tumor stage;Tumor Subtype;tumor-immune system interactions;Weight;Work

PROJECT_TITLE: Role of microbial-modulated bile acid receptor signaling in breast cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative It is important to map and preserve language areas of the brain during surgery for drug-resistant seizures, to prevent language impairments. At present, clinicians rely primarily on electrical stimulation of the brain for this, but now, language mapping can be performed with passive recordings of the brain's electrical activity. This project seeks to understand the similarities and differences between these two brain mapping techniques and to validate passive electrical recordings as a safer and equally effective alternative to electrical stimulation mapping.

PI_NAMEs: ARYA, RAVINDRA ;CRONE, NATHAN E (contact);FLINKER, ADEEN

PROJECT_TERMS: Accounting;Adopted;Adult;Anatomy;Area;Blinded;Brain;brain electrical activity;Brain Mapping;Case Series;Child;Client satisfaction;Clinical;clinical practice;Complement;Consumption;cortex mapping;data sharing;Diagnostic;Distant;Drug resistance;Electric Stimulation;Electrical Stimulation of the Brain;Electrocorticogram;Electrodes;Electroencephalography;Epilepsy;Evaluation;Evoked Potentials;Excision;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Human;Iatrogenesis;improved;Incidence;innovation;insight;Intractable Epilepsy;Involuntary Movements;Language;Language Disorders;language impairment;language outcome;Lesion;Maps;Measures;Methods;Modality;Modeling;Morphologic artifacts;Neurons;neurosurgery;Odds Ratio;Operative Surgical Procedures;oral motor;outcome prediction;Pain;Patient Compliance;patient safety;Patients;Population;Postoperative Period;predictive modeling;preservation;prevent;Procedures;prospective;Protocols documentation;rate of change;Resected;Resolution;Rest;Risk;Role;Safety;safety and feasibility;Seizures;Series;Site;Specificity;Speech;Standardization;Structure;Symptoms;System;Techniques;Testing;Time;United States;Validation;Variant

PROJECT_TITLE: Diagnostic validity and safety of high-gamma language mapping with intracranial EEG

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HD

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Infant Mortality;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative As regenerative medicine technologies bring us ever closer to generating organs in a dish, a central challenge is to understand how cells coordinate their behaviors into large-scale movements to generate proper form and function. We have discovered two novel collective cell behaviors reminiscent of embryonic gastrulation that occur during formation of epithelial placodes in the mammalian skin. Our model system offers an opportunity to understand these processes at unprecedented spatial and molecular resolution and to reveal how congenital birth defects arise when these processes go awry.

PI_NAMEs: DEVENPORT, DANELLE N (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Automobile Driving;Behavior;Biochemical;Biological Models;Body System;Cadherins;Cell Adhesion;cell behavior;cell fate specification;cell motility;Cells;Cellular Structures;Complex;Congenital Abnormality;Congenital Heart Defects;Craniorachischises;Cytoplasmic Tail;Cytoskeletal Modeling;Cytoskeleton;Developmental Biology;Diffusion;Embryo;Endowment;Epidermis;Epithelium;Exencephaly;experimental study;Failure;gastrulation;Generations;genetic predictors;Genetic Variation;Germ Layers;Hair;Hair follicle structure;Human;Image;imaging capabilities;Impairment;Individual;insight;Intercellular Junctions;Link;malformation;Maps;Mediating;Membrane;migration;Modeling;Molecular;Morphogenesis;Morphology;Motility;Motion;mouse genetics;Movement;Mus;Mutation;Myosin ATPase;Neural tube;Neural Tube Defects;novel;Organ;Organogenesis;Outcome;P-Cadherin;Pathway interactions;Pattern;Pattern Formation;Periodicals;Periodicity;Phenotype;planar cell polarity;prevent;Process;Proteins;Reaction;recruit;Regenerative Medicine;Resolution;response;Shapes;Skin;Spinal Dysraphism;stem cell migration;stem cells;Structural Congenital Anomalies;Structure;superresolution microscopy;System;Technology;Testing;Time;Tissue Engineering;Tissues;vertebrate embryos;Vertebrates

PROJECT_TITLE: The emergence of collective cell behaviors from intercellular interactions

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Childhood Injury;Contraception/Reproduction;Infant Mortality;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Preterm birth remains a significant cause of neonatal death and lacks an effective therapy. This proposal will test the therapeutic efficacy of Rytvela, a novel interleukin-1 receptor inhibitor, for the prevention of preterm birth and fetal injury due to bacterial infections in a nonhuman primate model. Completion of these experiments is essential for determining whether IL-1 is a key molecular target for preventing preterm birth and to enable translation of our findings into preclinical studies.

PI_NAMEs: ADAMS WALDORF, KRISTINA M. (contact);RAJAGOPAL, LAKSHMI

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acids;adverse pregnancy outcome;Amino Acids;amnion;amniotic cavity;Amniotic Fluid;anakinra;Anatomy;Animal Model;Animals;antagonist;antenatal;Antibiotics;Apical;Area Under Curve;Bacteria;Bacterial Infections;Birth;Brain;Caring;Catheterization;Cells;Cesarean section;Chorion;Chorionic villi;Chronic;Clinical;clinically significant;Colon;Continuous Infusion;cytokine;Cytokine Network Pathway;Data;Decidua;Development;digital;Dimensions;Dose;Drug Kinetics;effective therapy;efficacy evaluation;efficacy testing;Escherichia coli;experimental study;FDA approved;fetal;fetal blood;Fetal Lung;Fetal safety;Fetus;Flow Cytometry;Funding;Gene Expression;gene regulatory network;Half-Life;Histopathology;Hormonal;Human;Immune response;Immunologics;Induced Labor;Indwelling Catheter;Infant Mortality;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inhibitor;Injury;Interleukin-1;Interleukin-1 beta;Interleukin-1 Receptors;Intervention;intraamniotic infection;Intravenous Bolus;Invaded;Kineret;Letters;Lipopolysaccharides;Lung;manufacture;Mass Spectrum Analysis;Maternal-Fetal Exchange;Mediating;Membrane;Methods;microbial;Modeling;Molecular Target;Mus;Names;neonatal morbidity;Neonatal Mortality;neonatal sepsis;neonate;new technology;nonhuman primate;novel;Outcome;pathogen;Pathway interactions;Peptides;Perinatal;Perinatal mortality demographics;Pharmaceutical Preparations;Placenta;Placentation;Plasma;Population;preclinical study;Pregnancy;pregnant;Pregnant Women;Premature Birth;Premature Labor;prevent;Prevention;primary outcome;Prostaglandins;protein expression;Publishing;Rattus;reproductive;reproductive toxicity;Research;Safety;Sampling;secondary outcome;Signal Transduction;single-cell RNA sequencing;Specificity;Sterility;stillbirth;Streptococcal Infections;Streptococcus Group B;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;transcriptomic profiling;Translations;Treatment Efficacy;Uterine Contraction;Uterine Monitoring;Uterus;Vagina;Zika Virus

PROJECT_TITLE: Targeted Inhibition of Interleukin-1 beta to Prevent Preterm Birth


NIH_SPENDING_CATS: Diabetes;Nutrition

PI_NAMEs: TAMBORLANE, WILLIAM V (contact)

PROJECT_TERMS: Adult;Animal Model;Biopsy;Body Composition;Center for Translational Science Activities;Child;Clinical;clinical center;clinical investigation;Clinical Investigator;Clinical Research;clinical training;Clinical Trials;Collaborations;Complex;Consumption;cost;cost effective;data acquisition;Data Analytics;Diabetes Mellitus;Dietary Intervention;Discipline of Nursing;Equipment;Functional disorder;Funding;glucose and insulin clamps;Goals;Good Clinical Practice;Grant;Harvest;Human;human disease;Human Resources;In Vitro;Incubators;Indirect Calorimetry;Infrastructure;Infusion procedures;insight;Insulin;Investigation;Joints;Knowledge;Laboratories;Magnetic Resonance Imaging;medical schools;Medicine;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Mission;Multicenter Studies;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutics;nursing skill;Organizational Efficiency;Patients;Physicians;Play;Positron-Emission Tomography;Prevention;Principal Investigator;Process;Public Health;Research;research facility;Research Infrastructure;Research Personnel;Resources;Role;sample collection;Science;Scientist;Services;Spectrum Analysis;stable isotope;System;Techniques;Testing;Time;Training;Training Support;translational goal;Translational Research;translational study;United States National Institutes of Health

PROJECT_TITLE: Diabetes Translational Research Core


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Schizophrenia

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Current treatments for psychiatric disorders with deficits in cognitive and emotional Research Domain Criteria (RDoC) domains have limited efficacy, necessitating more effective treatment strategies. Disorders with NMDA receptor hypofunction lead to septohippocampal circuit dysfunction and circuit-specific cognitive dysfunction. Deep brain stimulation (DBS) alters focal and diffuse networks and has recently been posited as a treatment for psychiatric disorders. This project aims to evaluate the the role of electrophysiological networks involved in NMDA receptor hypofunction and utilize DBS to improve cognitive behavior.

PI_NAMEs: LEE, DARRIN JASON (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Amygdaloid structure;Animals;antagonist;Anxiety;Area;Attention;autism spectrum disorder;basal forebrain;Behavior;behavior measurement;Behavioral;behavioral impairment;behavioral outcome;Biological Markers;brain dysfunction;Brain region;career;catalyst;cell type;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;Collaborations;Data;Data Analyses;Deep Brain Stimulation;Depressed mood;Development;Diffuse;Disease;Doctor of Philosophy;effective therapy;Electric Stimulation;Electrodes;Electrophysiology (science);Elements;Emotional;Epilepsy;Etiology;Event-Related Potentials;Exhibits;Feedback;Foundations;Frequencies;Functional disorder;functional restoration;Funding;Genetic;genetic approach;Genetic Models;Glutamates;Hippocampus;Impaired cognition;Impairment;improved;insight;Interneurons;K-Series Research Career Programs;Knock-out;knowledge base;Lead;Learning;Machine Learning;Medial;Medial Septal Nucleus;Memory;Memory impairment;Mental disorders;Mentors;MK801;Modality;Modeling;Molecular;mouse model;multidimensional data;Mus;N-Methyl-D-Aspartate Receptors;National Institute of Mental Health;neural;neuroregulation;novel;novel strategies;NR1 gene;Nucleus Accumbens;Outcome Measure;Pacemakers;Parvalbumins;Patients;Pattern;pharmacologic;Phase;Phenotype;Play;Positioning Attribute;Prefrontal Cortex;prepulse inhibition;programs;Psychiatric therapeutic procedure;Reaction Time;Research;Research Design;Research Domain Criteria;Research Methodology;Research Personnel;Rest;Rodent Model;Role;Schizoaffective Disorders;Schizophrenia;septohippocampal;Services;Short-Term Memory;skills;Social Interaction;Specificity;Structure;targeted biomarker;Techniques;Testing;Thalamic structure;Therapeutic;Time;Training;Traumatic Brain Injury;treatment strategy

PROJECT_TITLE: Septohippocampal circuit deep brain stimulation for selective RDoC aspects of cognition


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric

PHR: NARRATIVE We will reveal the proteomic consequences and discover new protein-protein associations in the aneuploidy models that are relevant to human lung cancer and trisomy disorders, providing a deeper biological understanding of disease development process. The proteostasis rules discovered and datasets generated may offer opportunities in predicting the impact of a patient-specific gene copy number alteration on the abundance of specific disease biomarkers and thus the clinical phenotypes. The studies will provide a list of important protein targets for further functional studies and therapeutics managing disease phenotypes.

PI_NAMEs: LIU, YANSHENG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affect;Aneuploid Cells;Aneuploidy;Benchmarking;Biochemical;Biological;Biological Markers;Cell Lineage;Cell model;Cells;cellular targeting;Characteristics;Chromosomes;CISH gene;clinical phenotype;Collaborations;Complex;CRISPR/Cas technology;Data;data acquisition;Data Set;density;Development;Disease;Disease Management;disease phenotype;dosage;Dosage Compensation (Genetics);Down's Syndrome;Embryo;Epithelial Cells;Excision;experience;Fibroblasts;fitness;Gene Dosage;Gene Expression;Gene Expression Profiling;Genes;Genetic Diseases;Genome;genome-wide;Genomics;Genotype;Goals;Hela Cells;Homeostasis;Human;Human Genetics;improved;Individual;individual variation;Interferons;Literature;Location;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Messenger RNA;Modeling;Molecular;Molecular Conformation;Molecular Sieve Chromatography;Monozygotic twins;Mus;novel;Pathology;Pathway interactions;Patients;Phenotype;Play;Post-Transcriptional Regulation;posttranscriptional;Process;protein expression;protein function;protein protein interaction;Proteins;Proteome;Proteomics;proteostasis;Qualifying;Reproducibility;Research;response;Role;Signal Pathway;Signal Transduction;Squamous Cell Lung Carcinoma;Stress;Structure;System;Techniques;Therapeutic;tool;Transcription Process;Trisomy;Work

PROJECT_TITLE: Understanding proteome remodeling in aneuploidy

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Most patients with metastatic bladder cancer die of their disease. In the previous funding period, we studied CD24, a metastasis driver and prognostic marker and discovered CD24 is induced by Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2), which unlike CD24, has drugs available to block its function. In the current application, we propose to use novel approaches and technologies in both animal models and human samples to study the function of DDR2 in bladder cancer and then use this knowledge to develop unique, more effective therapies against the metastatic form of this disease.

PI_NAMEs: THEODORESCU, DAN  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Animal Model;Animals;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;Biological Markers;Biology;cancer cell;cancer cell subtype;cancer clinical trial;Cancer Model;Cancer Patient;Candidate Disease Gene;candidate identification;CD8-Positive T-Lymphocytes;cell type;Cells;cellular engineering;chemical carcinogen;Clinical;Collagen;Combined Modality Therapy;coronavirus receptor;Dasatinib;Data;Defect;Development;Dipeptidyl-Peptidase IV;discoidin domain receptor 2;discoidin receptor;Disease;Drug Combinations;druggable target;effective therapy;Effectiveness;Evaluation;exhaustion;Exposure to;Fibroblasts;Fibrosis;functional genomics;Funding;Future;Gene Expression;Gene Mutation;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Human;immune checkpoint blockade;Implant;improved;inhibitor;innovation;kinase inhibitor;Kinetics;Knockout Mice;Knowledge;Macrophage;Malignant neoplasm of urinary bladder;Malignant Neoplasms;mosaic analysis;Mus;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel strategies;Operative Surgical Procedures;Outcome;patient prognosis;Patients;PD-1 blockade;Peptide Hydrolases;Peptidyl-Dipeptidase A;Persons;Pharmaceutical Preparations;Phosphotransferases;Prognostic Marker;programmed cell death protein 1;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;recombinase-mediated cassette exchange;Recurrence;Resistance;response;Role;S100A2 gene;Sampling;Signal Transduction;small hairpin RNA;stromelysin 2;surgery outcome;synergism;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;transcriptome sequencing;Transforming Growth Factor beta;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Subtype;Tumor-infiltrating immune cells;Urothelial Cell;Urothelium

PROJECT_TITLE: Discoidin Domain Receptor Tyrosine Kinase 2 in bladder cancer progression

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROGRAM INTRODUCTION NARRATIVE: Platelets, circulating anucleate fragments of bone marrow megakaryocytes, provide primary hemostasis by forming hemostatic plugs at sites of vascular injury; likewise, platelet thrombi are predominantly responsible for the morbidity and mortality of arterial vascular disease. Although much is known about platelet biology, large gaps in our knowledge remain. Here, we propose to close these gaps by studying processes that occur in the platelet cytoplasm, on the platelet surface and in the interior of platelet thrombi, and as well as the summation of these processes when platelets participate in host-defense against sepsis.

PI_NAMEs: BRASS, LAWRENCE F (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Address;Alpha Granule;angiogenesis;Behavior;Binding;Biogenesis;Biological;Biology;Biomedical Research;Blood Platelets;Bone Marrow;Cells;Chromatin;Coagulation Process;Complex;Cytoplasm;Development;Digestion;Disease;DNA;extracellular;Fibrin;Goals;Golgi Apparatus;Hematology;Hemostatic Agents;Hemostatic function;Heparin;Histones;Host Defense;Human;Inflammation;Integrins;Knowledge;Laboratories;lymphatic development;Mediating;medical schools;Medicine;Megakaryocytes;Methods;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Names;Neoplasm Metastasis;neutrophil;novel;Oncology;Participant;Pathologic;pediatric department;Pediatric Hospitals;Pennsylvania;PF4 Gene;Philadelphia;Phosphatidylinositols;Physiological;platelet function;Play;Process;programs;protein protein interaction;Research;Role;Scientific Advances and Accomplishments;Sepsis;Signal Transduction;Site;Structure;Surface;System;Techniques;Testing;Thrombosis;Thrombus;tissue regeneration;tumor;Universities;Vascular Diseases;vascular injury

PROJECT_TITLE: Studies of Physiologic and Pathologic Platelet Plug Formation

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


NIH_SPENDING_CATS: Hematology

PHR: CORE A: NARRATIVE Core A, the Administrative Core, by providing fiscal administration, secretarial support, and consultative functions, is essential for the conduct of the Program Project.

PI_NAMEs: BENNETT, JOEL S. (contact)

PROJECT_TITLE: Admin core for the Studies of Physiologic and Pathologic Platelet Plug Formation

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PHR: Abstract: Platelets are a blood cell that is important for blood clotting and associated with severe human diseases such as heart attacks and strokes. In the bone marrow, platelets are derived from another type of blood cell called a megakaryocyte, and our proposed studies aim to understand how megakaryocytes develop normally so that they can make normal platelets. This research will have the potential to reveal novel therapeutic strategies to target this process.

PI_NAMEs: ABRAMS, CHARLES S. (contact)

PROJECT_TERMS: Address;Affect;Alpha Granule;Binding;Binding Proteins;Biochemical;Biogenesis;Biology;Blood;Blood Cells;Blood coagulation;Blood Platelets;Bone Marrow;Cell membrane;Cells;Collaborations;cytokine;Cytoplasmic Granules;Data;Defect;Development;Environment;Golgi Apparatus;GOLPH3 gene;Growth Factor;Hematopoiesis;Hematopoietic stem cells;Human;human disease;Impairment;in vivo;Indiana;Individual;Inflammation;Knock-out;Left;Link;Maintenance;Mediating;Megakaryocytes;Megakaryocytopoieses;member;Membrane;monomer;Morphology;Multivesicular Body;Mus;Mutate;Mutation;Myocardial Infarction;Neurons;novel;novel therapeutic intervention;Pathologic;Patients;Phenotype;Phosphatidylinositol Transfer Protein;Phosphatidylinositols;Phospholipids;Phosphorylation;Physiological;Platelet Activation;Play;Process;Production;Property;Protein Family;Protein Isoforms;protein transport;Proteins;Publications;Publishing;recruit;Regulation;Research;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Stroke;Syndrome;Testing;Thrombosis;trafficking;trans-Golgi Network;Transforming Growth Factor beta;Universities

PROJECT_TITLE: Novel Roles for Phosphoinositide Signaling in alpha-Granule Biogenesis


PHR: Project 2: Narrative Integrin-mediated cell-cell and cell-matrix adhesion is essential for many fundamental biologic processes and is an important contributor to human diseases such as thrombosis and cancer metastasis. Although the major platelet integrin αIIbβ3 has been a model for integrin function, its behavior may not be typical for integrins in general. The objective of this project is to compare the behavior of αIIbβ3 with that of the other integrins present in platelets to gain a more general understanding of integrin function, thereby enabling the future generation of more effective and safer anti-integrin therapeutics.

PROJECT_TERMS: Actins;Address;Adhesions;Agonist;Alanine;Alpha Granule;Behavior;Binding;Biochemical Reaction;Bioinformatics;Biological Process;Blood Platelets;Blood Vessels;Calpain;Cell-Matrix Junction;Cells;Chinese Hamster Ovary Cell;Clot retraction;Coagulation Process;cohesion;Collaborations;Complex;Computing Methodologies;Connective Tissue;Contracts;Cryoelectron Microscopy;Cytoskeletal Proteins;Cytoskeleton;Data;Defect;Development;extracellular;Extracellular Protein;Fibrin;Fibrinogen;Fibrinogen Receptors;Future Generations;Genetic;Goals;Hemostatic Agents;Hot Spot;Human;human disease;human induced pluripotent stem cells;in vivo evaluation;induced pluripotent stem cell;Integrin alphaVbeta3;integrin alphavbeta8;Integrin Binding;Integrins;interfacial;intermolecular interaction;Kinetics;Length;Ligand Binding;Link;Mechanics;Mediating;Megakaryocytes;Membrane;Methods;Modeling;Molecular Conformation;Mus;mutant;Myocardial Infarction;Neoplasm Metastasis;novel;optic trap;optical traps;Pathogenesis;Pathologic;Pharmacology;Physiological;Physiology;Polymers;protein data bank;protein protein interaction;Proteins;prototype;Regulation;Research Design;Resolution;Rest;Scanning;single molecule;Site;Spectrum Analysis;Stroke;Structure;Syndrome;Talin;Testing;Therapeutic;Thrombosis;Thrombus;Traction;Transfection;Transmembrane Domain;transmission process;Trauma;two-dimensional;Vinculin;Work

PROJECT_TITLE: Platelet Integrin Structure and Function


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: HEROLD, KEVAN C (contact)

PROJECT_TERMS: academic program;Adipocytes;Aging;Area;Award;base;Basic Science;Biomedical Research;brain metabolism;Capsicum;career;clinical center;clinical investigation;Clinical Research;Collaborations;Core Facility;Data;Diabetes Mellitus;Discipline;Ensure;Faculty;Funding;Future;glucose metabolism;Grant;Hepatic;Human Resources;innate immune pathways;Insulin Resistance;interest;Investigation;Investments;Liver;medical schools;Methodology;novel;Peer Review;Play;Process;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Role;Technology;Time;tool;Translational Research;translational scientist;Universities;Work

PROJECT_TITLE: Pilot & Feasibility Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Harm Reduction for Substance Misuse;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE State health services delivery policies have the potential to enhance access to drug addiction treatment and prevent overdose during public health disasters, but rigorous evidence is lacking. In this project, we study the implementation and outcomes of state health services delivery policies on rates of drug addiction treatment and fatal and non-fatal drug overdose during and following the COVID-19 disaster.

PI_NAMEs: EISENBERG, MATTHEW  (contact);MCGINTY, EMMA ELIZABETH

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;administrative database;aged;American;authority;Behavioral;Case Study;Characteristics;climate change;Computers;Counseling;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Sources;design;Disasters;Dose;Drug Addiction;Drug usage;Epidemic;Event;Face;Future;Harm Reduction;health care delivery;Health Policy;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Home;Individual;insight;interest;Internet;Interruption;Interview;Knowledge;Legal;Life;Maps;Medical;medical specialties;Methadone;Methods;Naloxone;naloxone dispensing;opioid use disorder;Outcome;Overdose;overdose death;overdose prevention;overdose risk;pandemic disease;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;Policy Developments;Policy Making;post-pandemic;prevent;prevention service;psychologic;Public Health;Public Policy;Relapse;response;Risk Factors;rural counties;Services;social;Source;Speed;stressor;Substance Use Disorder;symposium;System;telehealth;Telephone;Time;treatment services;United States;US State;Vertebral column

PROJECT_TITLE: Studying How State and Local Health Services Delivery Policies can Mitigate the Effects of Disasters on Drug Addiction Treatment and Overdose: A Mixed-Methods Study of COVID-19.

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


PHR: Project 3 Narrative Platelet activation and accumulation are part of the normal response to vascular injury, producing a platelet- rich plug that limits blood loss. Heart attacks and strokes occur when platelets are activated inappropriately, blocking blood flow and damaging tissues such as the heart and brain. The goal of this project is to better understand platelet plug formation and translate that understanding into improved methods to prevent thrombosis.

PROJECT_TERMS: 3-Dimensional;Agonist;Alpha Granule;Antibodies;Antiplatelet Drugs;Architecture;Arkansas;Arteries;blood damage;Blood flow;Blood Platelets;Blood Vessels;Brain;Carotid Arteries;cerebrovascular;Clot retraction;Coagulation Process;Collaborations;Complex;Computer Models;computer studies;Convection;Coronary artery;Defect;density;Devices;Diffusion;Engineering;Environment;Event;Face;Fibrin;Goals;Heart;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Hybrids;Image;improved;in vivo;Individual;inhibitor;Injury;m-calpain;Measures;Methods;Microfluidic Microchips;Microscopy;Molecular;Mus;Myocardial Infarction;Natural Immunity;novel;Pathologic;Penetration;Phospholipids;physical property;Physiological;Platelet Activation;Platelet Count measurement;platelet function;prevent;Process;reconstruction;regional difference;Regulation;Research Personnel;Resolution;response;Role;scale up;Scanning Electron Microscopy;Schools;Sepsis;Shapes;Stroke;Structure;Structure of jugular vein;submicron;Surface;Surgeon;Syndrome;System;systemic inflammatory response;Testing;Thrombin;Thrombosis;thrombotic;Thrombus;Tissues;Translating;Trauma;tumor growth;Universities;Variant;vascular injury;Veins;Venous Thrombosis;Work

PROJECT_TITLE: A systems approach to hemostasis and thrombosis


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Addressing racial and ethnic disparities in maternal health is a national priority. The proposed project aims to assess the effectiveness of the 2010 Patient Protection and Affordable Care Act and of the 2020 Families First Coronavirus Response Act in reducing racial and ethnic disparities in severe maternal morbidity.

PI_NAMEs: GUGLIELMINOTTI, JEAN R (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;Affordable Care Act;Age;aged;Birth;Childbirth;Conceptions;Coronavirus;COVID-19;Data;Databases;disparity reduction;Effectiveness;effectiveness evaluation;ethnic disparity;ethnic health disparity;Ethnic Origin;Ethnic Population;Evaluation;experience;Family;federal policy;federal poverty level;Goals;Health;Health Care Costs;health data;Health Disparities Research;health disparity;Health Insurance;Health Policy;hospital readmission;Hospitalization;improve minority health;Incidence;Income;indexing;Inpatients;Insurance Carriers;Insurance Coverage;Intervention;Labor Complications;Link;Low income;Low Income Population;Maintenance;Maternal Health;Maternal Mortality;maternal risk;Medicaid;Methods;Natural experiment;New York;Not Hispanic or Latino;Parents;Patients;Persons;Policies;policy recommendation;Postpartum Period;Pregnancy;Privatization;public health emergency;public health priorities;Quasi-experiment;racial disparity;racial health disparity;racial minority;Research;Research Project Grants;response;Sampling;Series;severe maternal morbidity;Testing;Uninsured;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Variant;young adult

PROJECT_TITLE: Reducing Racial and Ethnic Disparities in Maternal Health through Policy Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE A marked decrease in essential micronutrients such as iron perturbs the gut microbial community during intestinal inflammation, depleting beneficial commensals. Despite being central to maintaining the overall microbiota structure and functions in the face of perturbations, the mechanisms underlying commensal resilience remain poorly understood. By elucidating the mechanisms of how the prevalent gut bacterium Bacteroides thetaiotaomicron survives iron starvation in the inflamed gut, we will advance our knowledge of both fundamental bacterial physiology principles and resilience mechanisms of the gut microbiota.

PI_NAMEs: ZHU, WENHAN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Award;Bacterial Physiology;Bacteroides thetaiotaomicron;Dimensions;Disease;enteric pathogen;experimental study;Genetic;Goals;Gram-Negative Bacteria;gut bacteria;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Homeostasis;Human;in vivo;innovation;insight;Intestines;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Knowledge;Mediating;microbial;microbiota;Micronutrients;Modeling;Molecular;Nutritional Immunity;pathogen;Process;programs;Research;Research Project Grants;resilience;Shapes;Siderophores;Starvation;Structure;System;Untranslated RNA;uptake;Work

PROJECT_TITLE: Commensal resilience mechanisms in the inflamed intestine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


PHR: NARRATIVE Sepsis is a life-threatening complication of an infection, overwhelming the body’s defenses in spite of receiving antibiotics and this toxicity is in part due to neutrophil extracellular traps (NETs) released from activated white blood cells. Results of Project 4 should provide a better understanding of how platelets in the blood can decrease the toxicity of NETs and offers several new testable interventions to limit this toxicity based on this biology. This Project will interact with the other Projects on this grant to better understand platelet biology in health and disease.

PI_NAMEs: PONCZ, MORTIMER  (contact)

PROJECT_TERMS: Acceleration;Affect;Animals;Antibiotics;Antibodies;Anticoagulants;Arginine deiminase;Bacteria;Binding;Biology;Blood;Blood Platelets;Canis familiaris;Cations;Cause of Death;cell free DNA;Charge;chemokine;Clinical;Clinical Trials;Complex;Complication;Cytolysis;Deoxyribonuclease I;Deoxyribonucleases;Disease;DNA;Dose;efficacy study;Endothelium;Endotoxemia;extracellular;Generations;Goals;Grant;Health;Hemostatic Agents;Hemostatic function;Heparin;Histones;Human;In Vitro;in vitro testing;in vivo;Infection;Infusion procedures;Injury;Intervention;Leukocytes;Life;Lipopolysaccharides;Maximum Tolerated Dose;Microbe;microbial;microbicide;Microfluidics;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;novel therapeutics;Organ;Outcome;Pathologic;Patient Care;Patients;Peritonitis;PF4 Gene;Physiological;Pilot Projects;pilot trial;polyanion;pre-clinical;Predisposition;prevent;Process;Protamine Sulfate;Protein-arginine deiminase;Proteins;Resistance;response;Role;Sepsis;septic;septic patients;side effect;System;Testing;Therapeutic;therapy development;thrombotic;thrombotic complications;Toxic effect;Translating;Treatment Efficacy;United States;Variant

PROJECT_TITLE: Platelet Factor 4 and heparins in NETosis and Sepsis


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Anxiety disorders and insomnia are common during pregnancy and treatment with benzodiazepines and non- benzodiazepine sedative hypnotics is often indicated, yet rigorous and comprehensive safety data to inform the risk-benefit trade-off are sparse, evidence is conflicting, and numerous safety concerns have been raised. To address this critical information gap we propose to generate high-quality evidence on the safety of benzodiazepines and non-benzodiazepine sedative hypnotics during pregnancy considering a broad range of clinically relevant adverse pregnancy outcomes. Evidence generated will not only prevent unnecessary exposure for mother and fetus at time points during pregnancy when the medication may be harmful but will also provide guidance and reassurance as to when the medication can be used safely.

PI_NAMEs: BATEMAN, BRIAN THOMAS;HUYBRECHTS, KRISTA F (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Admission activity;adverse pregnancy outcome;American College of Obstetricians and Gynecologists;Anatomy;Anxiety Disorders;Benefits and Risks;Benzodiazepines;Central Nervous System;Child;clinically relevant;clinically significant;cohort;Confounding Factors (Epidemiology);Congenital Abnormality;Data;Data Sources;Databases;design;Discipline of obstetrics;Disease;Dose;early pregnancy;Etiology;experience;Fetal Development;Fetal Growth;Fetus;First Pregnancy Trimester;gamma-Aminobutyric Acid;Generalized Anxiety Disorder;Generations;Health Personnel;Healthcare;Human;hypnotic;Hypoglycemia;in utero;individualized medicine;innovation;Light;Low Birth Weight Infant;malformation;Mediating;Medicaid;medication safety;Mental Health;Mothers;multidisciplinary;Nature;Neonatal;neonatal outcome;Neurodevelopmental Disorder;Neurotransmitters;novel;Obsessive-Compulsive Disorder;offspring;Outcome;Panic Disorder;Pathological anxiety;Perinatal;Pharmaceutical Preparations;Pharmacological Treatment;Phobias;Physical Function;Placenta;population based;Post-Traumatic Stress Disorders;postnatal development;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal exposure;Prevalence;prevent;Privatization;Psyche structure;Psychiatry;Public Health;Recommendation;Relative Risks;Reporting;Research;respiratory;Risk;Role;Safety;Scanning;sedative;Sleep Disorders;Sleeplessness;Small for Gestational Age Infant;Social Anxiety Disorder;Specific qualifier value;Spontaneous abortion;Testing;Therapeutic Intervention;Time;Vulnerable Populations;Woman;Women's prevalence

PROJECT_TITLE: Safety of Benzodiazepines and Non-Benzodiazepine Sedative Hypnotics in Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Mutations in the gene that encodes the skeletal muscle type I ryanodine receptor (RYR1) result in a wide range of muscle disorders that collectively comprise the most common cause of non-dystrophic myopathy. The most severe cases of RYR1-related myopathy (RYR1-RM) exhibit a recessive pattern of inheritance and present in infancy with muscle hypotrophy, weakness, and a marked reduction in RYR1 protein expression. The overall goals of this project are to use two novel mouse models to define and interrogate patho-mechanisms responsible for recessive RYR1 RM and to evaluate the efficacy of interventions designed to counteract these aberrant mechanisms.

PI_NAMEs: DIRKSEN, ROBERT T (contact);DOWLING, JAMES J

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acute;Alleles;Animal Model;Cessation of life;Characteristics;Chemicals;Chronic;Clinical;Coupling;Data;disability;Disease;disease phenotype;Drug Targeting;early onset;ebselen;effective therapy;efficacy evaluation;endoplasmic reticulum stress;Epigenetic Process;epigenome;Exhibits;Exons;FDA approved;Functional disorder;GDF8 gene;Genes;Goals;Growth;Heterozygote;High Prevalence;Histone Deacetylase;Histone Deacetylase Inhibitor;Human Characteristics;infancy;Inheritance Patterns;Inherited;inhibitor;inhibitor therapy;insight;Intervention;Messenger RNA;Modeling;Molecular Chaperones;mortality;mouse model;Mus;Muscle;Muscle Fibers;Muscle Weakness;mutant;Mutate;Mutation;Myopathy;novel;Outcome;Outcome Measure;Output;Pathogenesis;Patients;Pharmaceutical Preparations;Phenocopy;Point Mutation;Pre-Clinical Model;Preclinical Testing;premature;primary outcome;protein degradation;protein expression;protein folding;protein function;receptor;receptor expression;receptor function;Receptor Gene;Respiratory Insufficiency;Ryanodine Receptor Calcium Release Channel;Sampling;Sarcoplasmic Reticulum;secondary outcome;Severities;Severity of illness;Skeletal Muscle;Sodium;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapy design;therapy development;Treatment Efficacy

PROJECT_TITLE: Pathophysiology and Treatment of Recessive RYR1 Related Myopathy


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: The current challenges in melanoma targeted therapy are due to an incomplete understanding of the mechanisms underlying the key influence of the tumor microenvironment on tumor cell response to therapeutic agents. The goal of the proposed project is to systemically explore how cancer-associated fibroblasts (CAFs) respond to BRAF inhibitors and remodel a protective tumor niche that induces growth and therapeutic escape in melanoma cells. The knowledge gained will advance the understanding of the contribution of CAFs in treatment responsiveness and melanoma recurrence. If successful, the data will accelerate the development of novel strategies to co-target both melanoma cells and the host microenvironment for improved patient outcomes.

PI_NAMEs: ZHANG, YUHANG  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Acceleration;Automobile Driving;beta catenin;Biological Process;Biology;BRAF gene;Bypass;Cancer Control;carcinogenesis;cell growth;Cell Line;cellular targeting;Coin;Complex;Data;design;Development;Drug resistance;drug resistance development;drug-sensitive;experimental study;Extracellular Matrix;Fibroblasts;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;Immune checkpoint inhibitor;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;innovation;Knowledge;Magic;Malignant Neoplasms;MAP Kinase Gene;Mediating;MEK inhibition;MEKs;Melanoma;Melanoma Cell;Metastatic Melanoma;Modeling;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;mutant;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutics;Nuclear;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Penetration;periostin;Pharmaceutical Preparations;Phenotype;Population;programs;Proliferating;Protein Secretion;Proteins;raf Kinases;Recurrence;Recurrent tumor;Relapse;Research;resilience;Resistance;response;Role;Series;Signal Pathway;Signal Transduction;Stromal Cells;targeted treatment;TCF7L2 gene;Testing;Therapeutic;Therapeutic Agents;therapy outcome;transcriptome;transcriptome sequencing;treatment response;tumor;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: 8. Project Narrative Currently, patients on the kidney transplant waitlist undergo repeat cardiac screening tests at frequent intervals, but relatively few interventions result. This project proposes to refine the cardiac screening strategy and personalize it for specific patient subgroups (e.g. elderly patients without diabetes mellitus), by examining strategies that reduce the frequency of cardiac testing and use performance-based risk stratification to reduce the number of patients who need cardiac testing. If successful, this project will reduce the cardiac testing burden and facilitate activation for transplant for patients on the kidney transplant waitlist.

PI_NAMEs: CHENG, XINGXING SHELLEY (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Accreditation;Age;analytical method;Award;Board Certification;Cardiac;Cardiopulmonary;career;Caring;Characteristics;Chronic Kidney Failure;Clinical;Clinical Investigator;clinical practice;clinical risk;cohort;comparative effectiveness trial;Coronary Arteriosclerosis;cost;design;Diabetes Mellitus;Effectiveness;Eligibility Determination;Evaluation;Event;experience;fitness;follow-up;Frequencies;Funding;Future;Goals;Grant;Guidelines;Healthcare;Heterogeneity;high risk;Hybrids;improved;Information Systems;innovation;Institution;Intervention;Intervention Trial;Kidney;Kidney Transplantation;Knowledge;Lead;Machine Learning;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;older patient;Outcome;patient oriented research;patient subsets;Patients;Performance;personalized strategies;Phase;Physical Performance;Population;Process;prognostic value;programs;prospective;Quality-Adjusted Life Years;Recommendation;recruit;relative effectiveness;Research;response;Risk;Risk Factors;risk stratification;Science;screening;skill acquisition;skills;Specificity;Sum;System;Testing;Time;Training;Transplant Recipients;Transplantation;United States;Wait Time;Waiting Lists;Walking;Work

PROJECT_TITLE: Refining repeat screening for coronary artery disease in kidney transplant candidates


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Prevention;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Diabetic foot infection is one of the most detrimental complications in diabetic population and along with impaired wound healing a main contributor of lower leg amputations in diabetic patients, resulting in a major impact to patients’ quality of life and significant burden and associated costs to the health care system. Our long term goal is to target intracellular pathogens in patients with diabetic foot ulcers (DFUs) by understanding mechanisms by which human skin fights intracellular infection and participates in wound healing. We will implement this knowledge to develop novel advanced therapeutic approaches to prevent and treat diabetic wound and skin infections.

PI_NAMEs: PASTAR, IRENA ;STRBO, NATASA ;TOMIC-CANIC, MARJANA  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Acute;acute wound;Adult;Affect;Agonist;Amputation;Animal Model;Anti-Bacterial Agents;antimicrobial;Bacteria;Cells;Chronic;Clinical;comparative genomics;Complications of Diabetes Mellitus;cost;Cutaneous;Data;Data Set;Development;diabetic;Diabetic Foot;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Down-Regulation;effective therapy;Epithelium;Evaluation;Exposure to;extracellular;fighting;FOXM1 gene;Functional disorder;Gene Expression Profile;Genetic Transcription;Genus staphylococcus;Goals;healing;Healthcare Systems;Human;human model;Immune;Impaired wound healing;Impairment;in vivo;Infection;Infection prevention;Infectious Skin Diseases;Inflammasome;Inflammation;Inflammatory Response;Innate Immune Response;insight;Intervention;keratinocyte;Knowledge;Leg;limb amputation;Lower Extremity;Macrophage;Mediating;methicillin resistant Staphylococcus aureus;microbiome;microorganism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;new therapeutic target;non-diabetic;novel;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;perforin 2;Phagocytes;Population;prevent;Prevention;Process;Proteins;Quality of life;Recurrence;response;Risk;Role;Sampling;Skin;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;Staphylococcus epidermidis;Testing;Therapeutic;Tissue Preservation;Tissue Sample;Tissues;TLR1 gene;TLR2 gene;TLR6 gene;Transcriptional Regulation;transcriptomics;treatment strategy;Ulcer;Work;wound;wound environment;wound healing;Wound Infection;Wound models;γδ T cells

PROJECT_TITLE: Prevention of intracellular infection in diabetic wounds by commensal Staphylococcus epidermidis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

PHR: Narrative The goal of this project is to test the effect on spatial working memory of focused ultrasound for noninvasive brain stimulation and targeted drug delivery directed to the dorsolateral prefrontal cortex and dorsal striatum. Focused ultrasound could provide a new research tool for establishing causal brain-behavior relationships, mapping neural circuits in healthy humans, and a novel method for introducing neuroactive drugs that do not cross the intact blood-brain barrier (BBB). Focused ultrasound therapy could become a non-surgical alternative to treat cognitive impairments in patients with neurological or psychiatric disorders who experience working memory deficits.

PI_NAMEs: FERRERA, VINCENT P (contact);KONOFAGOU, ELISA E.

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease patient;Area;arterial spin labeling;Attention deficit hyperactivity disorder;autism spectrum disorder;Autopsy;awake;Behavioral;Blood - brain barrier anatomy;Brain;brain behavior;Brain region;caudate nucleus;Chemicals;Clinical Trials;Cognitive deficits;Computer software;Contralateral;Corpus striatum structure;Data;Decision Making;Deep Brain Stimulation;Dementia;Dorsal;Dose;Drug Delivery Systems;Drug Targeting;Dyskinetic syndrome;Dysmetria;effectiveness testing;Electric Stimulation;executive function;experience;experimental study;Focused Ultrasound;Focused Ultrasound Therapy;Frequencies;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Histology;Human;human data;Impaired cognition;Impairment;improved;Intravenous;intravenous injection;Ipsilateral;Length;Magnetic Resonance Imaging;Maps;Measures;Mediating;Medical;member;Memory;Memory Disorders;Memory impairment;Mental disorders;Methods;Microbubbles;Motor;Motor Cortex;Movement;Nervous System Disorder;neural circuit;neuroregulation;Neurotransmitters;nonhuman primate;noninvasive brain stimulation;novel;novel therapeutics;Parkinson Disease;Patients;Performance;Perfusion;Persons;Pharmaceutical Preparations;Physiologic pulse;Physiological;Physiology;preclinical efficacy;preclinical safety;Predisposition;Prefrontal Cortex;pressure;programs;Research;Safety;Schizophrenia;Short-Term Memory;Speed;Structure;Testing;Thermometry;Time;tissue oxygenation;tool;touchscreen;Tremor;Water;Work

PROJECT_TITLE: Focused ultrasound for memory disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: This T32 application, the Center for Drug Discovery “Training Program on Medications Development for Substance Use Disorder (SUD)” is to provide broad training to PhD students and postdoctoral scientists on discovery and development of medicines to treat SUD. The Training Program rationale is driven by the socioeconomic burden and medical need associated with lack of safe and effective medications to address SUD in the US and globally. The Training Program blends mentorship, coursework, and research activities supervised by Center for Drug Discovery faculty based at Northeastern University, McLean Hospital/Harvard Medical School, and Tufts University and Medical Center to equip trainees to develop as productive biomedical research scientists, with consummate expertise in SUD medications development.

PI_NAMEs: BOOTH, RAYMOND G.;MAKRIYANNIS, ALEXANDROS  (contact);PARONIS, CAROL A

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Development;Pharmaceutical Preparations;Substance Use Disorder;Training Programs

PROJECT_TITLE: Training Program on Development of Medications for Substance Use Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Family caregivers of persons with dementia (PwDs) often lament missed opportunities to record meaningful moments with their loved ones, experience distressing and disabling grief in advance of the PwD’s physical death and report a deterioration of their relationship with the PwD. We propose to adapt our online Living Memory Home bereavement reminiscence resource to the context of home-based caregiver-PwD dyads as a pre-loss activity so that memories can be recalled and recorded collaboratively between the “care pair”. We expect it will prove a welcome resource, reduce feelings of caregiver pre-loss grief, and improve the quality of the care pair’s relationship.

PI_NAMEs: FALZARANO, FRANCESCA ;PRIGERSON, HOLLY GWEN (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adult;Advance Care Planning;advanced disease;affection;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;attentional control;Bereavement;Cancer Patient;Caregiver Burden;caregiver stress;Caregiver well-being;Caregivers;caregiving;Caring;Case Study;Cessation of life;Clinical;Confusion;Cues;Data;Decision Making;Dementia;dementia care;Dementia caregivers;dementia caregiving;deprivation;design;Deterioration;Diagnosis;Disabling;Disease;Distress;efficacy study;Event;Exclusion;experience;Family Caregiver;Feeling;Feeling suicidal;follow-up;Functional disorder;Funding;Grief reaction;Happiness;Health;Home;Hypertension;Impairment;improved;Institutionalization;Life;Link;Loneliness;loved ones;Mediator;Medical;meetings;Memory;Memory Loss;Mental Depression;Methodology;Moods;Myocardial Infarction;Nursing Homes;Outcome;Pain;Patients;Persons;Play;primary outcome;Psyche structure;psychosocial;Psychosocial Deprivation;Public Health;Quality of Care;Quality of life;Randomized;Randomized, Controlled Trials;Regrets;Reporting;Research;Resources;Risk Reduction;Role;Sampling;satisfaction;shared memory;Sociology;Standardization;theories;Therapeutic Intervention;Time;Treatment Efficacy;United States;United States National Institutes of Health;web app;yearning

PROJECT_TITLE: The Living Memory Home: Reducing Grief and Improving Relationships between Home-based Patients with ADRD and Their Family Caregivers

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Overall Narrative Transplantation tolerance, a state of immune hyporesponsiveness to a graft following cessation of immunosuppressive therapy, can prevent complications from life-long global immunosuppression but is rarely attained in the clinic. This PPG addresses the barriers to both the induction and long-term maintenance of transplantation tolerance, and explores two potential solutions that leverages the natural ability of pregnancy to tolerize fetus-reactive T cells and harnesses the capacity of chronic antigen exposure to drive immune hypofunction.

PI_NAMEs: ALEGRE, MARIA-LUISA  (contact);CHONG, ANITA S

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Address;Affinity;Alloantigen;Animals;Antigens;Avidity;Biological Markers;biomarker identification;CD8-Positive T-Lymphocytes;CD8B1 gene;Chronic;Clinic;Cross Reactions;cytokine;design;Down-Regulation;epigenome;Exhibits;Exposure to;Fetus;Functional disorder;Goals;Graft Rejection;Heterogeneity;Histocompatibility Antigens;Immune;Immunosuppression;Infection;Inflammatory;Injections;Laboratory mice;Life;Link;Maintenance;Mediating;meetings;Memory;memory acquisition;Microsurgery;Modeling;Molecular;Monitor;mouse model;novel;novel strategies;novel therapeutic intervention;Paper;Patients;Phenotype;Predisposition;Pregnancy;prevent;Process;Productivity;programs;Publishing;Regimen;Regulatory T-Lymphocyte;Resistance;sex;Signal Transduction;Splenocyte;synergism;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic immunosuppression;Time;transcriptome;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Infections and the Stability of Transplantation Tolerance


NIH_SPENDING_CATS: Transplantation

PI_NAMEs: ALEGRE, MARIA-LUISA  (contact)

PROJECT_TITLE: Administrative Core (Core A)


PI_NAMEs: CHONG, ANITA S (contact)

PROJECT_TERMS: Acceleration;Address;Allografting;Anesthetics;animal breeding;Animals;Breeding;Cells;cost;Disparity;Ensure;experimental study;Genotype;Harvest;Health;heart allograft;Heart Transplantation;Histology;Human Resources;Immune;Immunosuppressive Agents;Infection;lymph nodes;Maintenance;Microsurgery;Monitor;Operative Surgical Procedures;Organ;Phenotype;Principal Investigator;Procedures;programs;Research Personnel;Resources;Role;screening;Services;Skin Transplantation;Source;Specific qualifier value;Spleen;Splenocyte;Standardization;Surgical sutures;T memory cell;Therapeutic immunosuppression;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Animal and Microsurgery Core (Core B)


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

PROJECT_TERMS: Address;Affinity;Alloantigen;anergy;Animals;Antigens;Avidity;CD4 Positive T Lymphocytes;cell fixing;Cells;Characteristics;Chronic;Clone Cells;cytokine;Data;density;design;Down-Regulation;Epigenetic Process;exhaustion;Exposure to;Functional disorder;Genetic Transcription;Graft Rejection;Heart Transplantation;Heterogeneity;immunosuppressed;Immunosuppression;improved;Individual;Infection;Inflammation;Inflammatory;Ligands;Listeria monocytogenes;loss of function;Maintenance;Mediating;MHC Class II Genes;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Pathway interactions;patient tolerability;peptide I;Peptide/MHC Complex;Population;post-transplant;Predisposition;prevent;programs;Quality of life;Regulatory T-Lymphocyte;Resistance;Rest;Role;Signal Transduction;Specificity;Splenocyte;Systemic infection;T memory cell;T-Lymphocyte;Testing;TNFSF5 gene;transcription factor;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Addressing Vulnerabilities to the Maintenance of Transplantation Tolerance


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is a common cause of hospitalization, especially among racial and ethnic minorities. Yet, treatments that work to address alcohol use, including medications and cognitive behavioral therapy, are typically not offered in the hospital. We plan to compare the impact of different treatment approaches on promoting AUD treatment engagement and reduction in alcohol use among a diverse sample of patients with untreated AUD.

PI_NAMEs: EDELMAN, E. JENNIFER (contact);KILUK, BRIAN D.

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Acute;addiction;Address;Advocate;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol use disorder;Alcohols;Behavior Therapy;Behavioral;Biological Markers;Black, Indigenous, People of Color;brief intervention;care outcomes;Caring;Clinical Trials;clinically relevant;Cognitive Therapy;Collaborations;compare effectiveness;Computerized Cognitive Behavioral Therapy;Computers;cost;Cost Effectiveness Analysis;cost-effectiveness ratio;Data;digital intervention;Discrimination;Disparity population;disparity reduction;Dissemination and Implementation;Educational Status;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation design;Emergency department visit;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;evidence base;food insecurity;Fright;future implementation;health care service utilization;Health Disparities Research;Health Promotion;Health Services;Health Services Accessibility;Heavy Drinking;hospital readmission;Hospitalization;Hospitals;housing instability;Hybrids;implementation science;incremental cost-effectiveness;indexing;Individual;information gathering;innovation;Interview;Left;longitudinal analysis;Mediation;Medical;medical complication;Medicine;Morbidity - disease rate;mortality;multidisciplinary;Outcome;patient population;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;phosphatidylethanol;primary outcome;Process;process evaluation;Process Measure;Qualifying;Race;racial diversity;racial minority;racial population;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reproducibility;Research;Research Design;Resources;response;routine care;Sampling;secondary outcome;social health determinants;Standardization;Stigmatization;Structural Racism;Surveys;Technology;Telephone;three-arm trial;trial design;United States;United States Food and Drug Administration;Urban Hospitals;Withdrawal;Work

PROJECT_TITLE: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications, and CBT4CBT: A randomized clinical trial in a diverse patient population


ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Better knowledge of the factors leading to optimizing mobility and developing efficacious and effective interventions to promote independence will have a major impact on practicing evidence-based geriatric medicine and public health.

PI_NAMEs: ESSER, KARYN A;MANINI, TODD  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;age related;age related decline;Aging;American;Animals;Apoptosis;Area;Artificial Intelligence;Autophagocytosis;Basic Science;Behavior Therapy;Behavioral;Behavioral Sciences;Biological;Biological Markers;Biostatistics Core;Caloric Restriction;Capsicum;career development;Circadian Rhythms;Clinical;Clinical Research;clinical translation;Clinical Trials;Cognitive;cognitive function;Communities;comorbidity;Data Science;Development;Dietary Intervention;disability;Disability prevention;Disability research;Discipline;Education;education research;effective intervention;efficacious intervention;efficacy evaluation;Energy Metabolism;Engineering;Environment;Epidemiology;ethnic disparity;Evidence based practice;exercise intervention;experience;Florida;Funding;Future;Geriatrics;Geroscience;Goals;handheld mobile device;Health;health disparity;Hospitalization;Human;Impairment;improved mobility;Individual;Inflammation;Institution;interdisciplinary approach;Intermittent fasting;Intervention;Investigation;Knowledge;late life;Leadership;Locomotion;Metabolism;minority disparity;Mission;Mitochondria;Mobility disability;Molecular Biology;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;novel strategies;Nutraceutical;Obesity;older adult;Older Population;Oxidative Stress;pharmacologic;Phase;Physical Exercise;Physical Function;physical model;Physical Performance;physically handicapped;preclinical study;prevent;Prevention;Program Development;programs;psychosocial;Public Health;public health relevance;Quality of life;racial minority;Research;research and development;Research Personnel;Research Support;Research Training;Resources;Risk Factors;Role;sarcopenia;Science;Services;Skeletal Muscle;skills;success;Technology;Testing;Training;Translating;Translational Research;Translations;Universities;virtual

PROJECT_TITLE: University of Florida Older Americans Independence Center (OAIC)


NIH_SPENDING_CATS: Aging

PI_NAMEs: MANINI, TODD  (contact)

PROJECT_TITLE: Leadership and Administrative Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Epilepsy;Heart Disease;Lung;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Public Health Relevance The proposed work will determine the causal cardiorespiratory effects resulting from co-activation of sympathetic and parasympathetic autonomic nervous systems in autonomically compromised subjects. This confluence of events lies behind Sudden Unexpected Death from Epilepsy (SUDEP) in various animal models. Systematic physiological monitoring across those models, acute and chronically, will provide insights relevant towards the treatment and prevention of some of the over 4,000 annual human deaths from SUDEP in the United States.

PI_NAMEs: KOLIATSOS, VASSILIS E (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Age;Air Movements;American;Anesthesia procedures;Animal Model;Animals;Apnea;aspirate;Autonomic Dysfunction;Autonomic nervous system;awake;Blood;Blood Pressure;Bone Screws;Bradycardia;Brain;Brain Stem;Cardiac;Catheters;Central Sleep Apnea;Cessation of life;Chronic;Clinical Data;Complication;Coupled;Data;Data Set;Development;Disease;Diving;diving reflex;Drops;Electrocardiogram;Electrocorticogram;Electrodes;Epilepsy;Event;Family;Female;fighting;Heart;Heart Arrest;Heart Rate;Human;implantable device;Individual;insight;intraperitoneal;Intraperitoneal Injections;Kainic Acid;Larynx;Link;Long-Evans Rats;male;Measures;Modeling;Monitor;neural;Neurons;Nose;novel;Organ;Oxygen;Pathology;Pathway interactions;peripheral blood vessel;Physiologic Monitoring;Physiologic pulse;Physiological;prevent;Prevention;public health relevance;Rattus;Recovery;Reflex action;respiratory;Respiratory Diaphragm;response;Rest;Role;Seizures;Signal Transduction;subcutaneous;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;System;Tetanus;Time;United States;vasoconstriction;Work

PROJECT_TITLE: Sequence of physiological events during oxygen conserving reflex activation leading to sudden death in epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: ANTON, STEPHEN D (contact)

PROJECT_TERMS: Address;Adherence;Affect;Aging;American;Ancillary Study;Area;Behavioral;Behavioral Research;behavioral study;Biological;Budgets;career development;Clinical;clinical investigation;Clinical Research;clinical translation;clinical trial implementation;Clinical Trials;Cognitive;Collaborations;Collection;Data;design;Development;Disability prevention;Discipline;early phase clinical trial;Education;education research;efficacy study;Elderly;Environment;Environmental Risk Factor;Ethnic Origin;faculty research;Florida;Fostering;functional decline;functional disability;Funding;Future;Goals;health disparity;high risk;Human Resources;improved;improved mobility;Infrastructure;innovation;Interdisciplinary Study;Intervention;Intervention Studies;Investigation;Joints;Lead;Leadership;Measures;Mentors;Minority;Mobility decline;neural;neuroregulation;Nutritional Study;Observational Study;older adult;Older Population;Pain;Pathway interactions;Patient Recruitments;pharmacologic;Phase II Clinical Trials;Physical Function;Physiological;Pilot Projects;pre-clinical research;preclinical study;Progress Reports;protocol development;Race;Records;recruit;Research;research facility;research faculty;Research Personnel;research study;Resources;response;Role;Science;Scientist;senior faculty;sex;social;Specimen;standardize measure;success;synergism;Technology;therapy design;Training;Translational Research;Translations;United States National Institutes of Health;Universities;University resources;Walking

PROJECT_TITLE: Clinical Research Core