NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: WHITMAN-WALKER INSTITUTE, INC.

PHR: 8. Project Narrative In Ecuador, the HIV epidemic is concentrated primarily among transgender women—those who identify as women or on the transfeminine spectrum and who were assigned a male sex at birth. There is an urgent need for status-neutral HIV interventions tailored to this high-risk group. Through this K01, the candidate will assess the mechanisms through which intersectional discrimination exerts its impact on linkage to HIV prevention and care for transgender women in Ecuador while extending and deepening their research skills to receive advanced training in intersectional qualitative, quantitative, intervention development, and grant writing. Findings will inform policymakers and development of culturally tailored HIV interventions that will mitigate intersectional discrimination and reduce HIV burden in this NIH-designated disparity population.

PI_NAMEs: AGUAYO ROMERO, RODRIGO ARMANDO (contact)

PROJECT_TERMS: Address;Affect;African ancestry;AIDS prevention;American;Area;bilingualism;Birth;Black race;care outcomes;career;Caring;cis-male;classism;Collaborations;Communities;community advisory board;Data;design;Discrimination;Disparity population;Ecuador;Ecuadorian;Enrollment;Epidemic;Epidemiologic Methods;Epidemiology;experience;Exposure to;Face;Funding;Future;Gender Identity;Grant;Health Disparities Research;health disparity populations;Health Priorities;High Prevalence;high risk;high risk population;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Immigrant;Incidence;Indigenous;Individual;infection rate;intersectionality;Intervention;Intervention Trial;Interview;Knowledge;Latin America;Link;longitudinal analysis;longitudinal design;male;marginalization;Mentored Research Scientist Development Award;Mentorship;Methods;model development;Modeling;nonbinary;Outcome;Pathway interactions;peer;Persons;Phase;Policy Developments;Policy Maker;Population;Positioning Attribute;Poverty;pre-exposure prophylaxis;Prevalence;Prevention;Program Development;programs;Qualitative Methods;queer;Race;racism;Randomized, Controlled Trials;recruit;Research;research and development;Research Design;Research Personnel;resilience;Risk Behaviors;Sampling;sex;Sexual and Gender Minorities;skill acquisition;skills;social media;social stigma;Socioeconomic Status;socioeconomics;Surveys;System;Testing;therapy design;therapy development;Training;Training Activity;transfeminine;transgender;transgender women;United States National Institutes of Health;Visit;Woman;Writing

PROJECT_TITLE: Intersectional discrimination and linkage to HIV prevention and care in transgender women in Ecuador

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: This project is relevant to public health because it will examine the extended amygdalar and respiratory circuits involved in sudden unexpected death in epilepsy (SUDEP), the most common cause of death in refractory epilepsy patients. The proposed research builds on our preliminary data indicating that the extended amygdala is a critical mediator in mortality in a mouse model of SUDEP. The results of this work will provide a foundation to identify potential new mechanistic targets and strategies to modify SUDEP risk, which aligns with the mission of NINDS to reduce the burden of neurological disease.

PI_NAMEs: NOBIS, WILLIAM PAUL (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Amygdaloid structure;Apnea;Arousal;audiogenic seizure;Brain Stem;Breathing;Cause of Death;Cell Nucleus;Central Sleep Apnea;Cessation of life;Chronic;Clinical;clinical translation;critical period;Data;DBA/1 Mouse;Development;Disease;Electric Stimulation;Electrocardiogram;Electrocorticogram;Electroencephalography;Electrophysiology (science);Epilepsy;Evaluation;Fiber;FOS gene;Foundations;Functional disorder;Future;Genetic;Genetic Recombination;Goals;high risk;Human;Hypoventilation;Impairment;improved;in vivo;innovation;Intervention;Intractable Epilepsy;Light;Maps;Medial;Mediating;Mediator;Mission;Modeling;Monitor;mortality;mouse model;Mus;Myocardial dysfunction;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurons;neurophysiology;neuroregulation;Neurosciences;novel;novel therapeutics;Opioid;Opsin;optogenetics;Outcome;Outcome Study;Output;parabrachial nucleus;patch clamp;Patients;Pharmacologic Substance;Photometry;Physiologic Monitoring;Physiologic pulse;Pontine structure;Population;Pre-Clinical Model;prevent;preventable epilepsy;Prosencephalon;Public Health;Research;Respiration Disorders;respiratory;Risk;risk stratification;Role;Seizures;selective expression;Structure;Structure of terminal stria nuclei of preoptic region;Sudden Death;sudden unexpected death in epilepsy;Synapses;System;Techniques;Testing;Time;tool;Translating;Ventilatory Depression;Viral;Whole Body Plethysmography;Work

PROJECT_TITLE: The role of brainstem projecting extended amygdala neurons in sudden unexpected death in epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: This is a training program from investigators at the University of North Carolina Chapel Hill focused on training the next generation of scientific leaders working in tumor immunology, tumor immunotherapy, and stem cell transplant immunology.

PI_NAMEs: SERODY, JONATHAN S. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Grant;Immunotherapy;Training

PROJECT_TITLE: UNC Immunotherapy Training Grant (IM-TAG)


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: FARGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Project Narrative: Alzheimer’s disease (AD) is the most common type of dementia in the elderly, which accounts for 60-80% of cases. Currently, an estimated 5.7 million Americans of all ages have AD. VGF(non-acronymic) is synthesized by neurons in the brain where it promotes growth and survival of neurons, and is involved in neurogenesis, synaptogenesis and energy homeostasis. Therefore, strong scientific premises indicate that increasing VGF levels in the brain could be a promising therapeutic strategy to treat AD. The long-term goal of the proposed research is to design a non-viral gene delivery carrier for efficient delivery of pVGF to brain through intravenous and intranasal routes for prevention and treatment of aging-related cognitive decile including AD. The studies will be conducted in vitro and in vivo in Wild Type, amyloid 5xFAD and PS19 mice models.

PI_NAMEs: KANEKIYO, TAKAHISA ;SINGH, JAGDISH  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Acceleration;addiction;Age;Age Months;Age-associated memory impairment;aged;aging related;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;Animals;aqueous;Astrocytes;Attenuated;beta amyloid pathology;Binding;Biodistribution;Biological Assay;biomaterial compatibility;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain endothelial cell;brain parenchyma;Bypass;Cell Culture Techniques;Cells;Cerebrum;Chitosan;Cognitive;cohort;Complementary DNA;Complex;Coupled;cytotoxicity;Dementia;design;Development;Drug Kinetics;effective therapy;Elderly;Encapsulated;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Film;Functional disorder;Gene Delivery;gene delivery system;gene therapy;Genes;Goals;Growth;Hemolysis;Homeostasis;Human;Hydration status;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;infrared spectroscopy;innovation;Intranasal Administration;Intravenous;intravenous administration;late life;Learning;Ligands;Liposomes;Mannose;Measures;Mediating;Medicine;Memory;Mental disorders;Micelles;model design;Modeling;mouse model;Mus;nanomicelles;nanoparticle;Nerve;Nerve Degeneration;Nervous System Disorder;neurobehavior;Neurodegenerative Disorders;neurogenesis;neuronal survival;Neurons;NMR Spectroscopy;non-viral gene delivery;novel;Omega-3 Fatty Acids;Organ;Organoids;overexpression;particle;Particle Size;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;penetratin;Penetration;Peptides;Phenotype;Plasmids;Play;Polymers;Prevention;rabies virus glycoprotein G;receptor;Research;Role;Route;self assembly;SLC2A1 gene;Surface;synaptic function;synaptogenesis;tau Proteins;tau-1;Techniques;Testing;Tetanus Toxin;tetanus toxin fragment C;Therapeutic;Therapeutic Effect;Thinness;Toxic effect;Transfection;Transferrin;uptake;vector;Western Blotting;Wild Type Mouse;zeta potential

PROJECT_TITLE: Therapeutic Strategy to Treat Alzheimer's Disease by VGF Delivery into Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: Columbus

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The objectives of this study are to determine the impact of exposure to adverse activity spaces characterized by high area-levels of violence, policing activity, and racial exclusivity on everyday perceptions of safety, physiological stress, mental health and substance use. We will also consider whether the impact of adverse exposures on safety, stress, and health is greater for youth who believe others perceive their race to be Black in public interactions. Finally, we will explore whether changes in the extent and impact of adolescent adverse activity space exposures have occurred since the period prior to the COVID-19 pandemic.

PI_NAMEs: BROWNING, CHRISTOPHER R (contact);CALDER, CATHERINE A

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;adolescent health;Adult;Age;Area;behavioral health;Black race;C-reactive protein;Caregivers;children of color;Chronic Disease;cohort;Communities;COVID-19 pandemic;Data;Data Analyses;Data Collection;Data Sources;design;Development;Dimensions;Disparity;Ecological momentary assessment;Exhibits;experience;Exposure to;Hair;Health;heart rate variability;Heterogeneity;Home;Hydrocortisone;Individual;Inflammation;Inflammatory;innovation;Intervention;Investigation;killings;Link;Location;Measures;Mediating;Mental Health;metropolitan;microaggression;neglect;Neighborhoods;novel;Outcome;Patient Self-Report;Perception;Personal Satisfaction;Phase;Physiological;Police;Process;psychologic;Race;racial difference;racial disparity;racial diversity;racial identity;Reaction;Research;Resolution;response;Risk;Role;Safety;Sampling;segregation;Shapes;Stress;stress reactivity;Structural Racism;substance use;Surveys;Time;Victimization;Violence;violence exposure;Work;Youth

PROJECT_TITLE: Activity Space Adversity and Racial Disparities in Adolescent Health

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE New epidemiologic tools that identify in real time communities with high amounts of circulating HIV may enhance efforts to reduce HIV transmission and substantially contribute to ending the HIV epidemic. During the COVID-19 pandemic we built a robust wastewater sampling program for the Houston region that includes weekly assessment of 39 wastewater collection sites covering about 4 million residents and our preliminary data demonstrate that HIV can also be detected in wastewater. The project will apply our pioneering wastewater sampling program as a powerful new tool to identify geographic areas with a high active burden of HIV, reflecting substantial numbers of people with undiagnosed or untreated HIV infection, and respond to those areas with effort to reduce unsuppressed HIV in those geographic areas.

PI_NAMEs: GIORDANO, THOMAS P (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 2019-nCoV;Acceleration;antiretroviral therapy;Area;authority;Bioethics Consultants;Caring;Clinical Data;Collection;Communities;Complex;COVID-19;COVID-19 burden;COVID-19 monitoring;COVID-19 outbreak;COVID-19 pandemic;Data;Data Reporting;Detection;Diagnosis;Diagnostic;Diagnostic tests;Disease Outbreaks;Epidemic;epidemiological model;Epidemiologist;Epidemiology;ethical, legal, and social implication;Ethics;experience;Geographic Locations;Geography;Health;health care availability;HIV;HIV diagnosis;HIV Infections;Human;Human immunodeficiency virus test;improved;Individual;Infection;Laboratories;Link;Methods;Monitor;Neighborhoods;Nose;novel;novel strategies;Nucleic Acids;outreach;Periodicals;Persons;Physicians;Plants;Poliomyelitis;Population;predictive modeling;preference;Prevention;programs;Public Health;public health intervention;Recommendation;Reporting;Reproducibility;Research;Research Personnel;Resolution;Resources;routine care;Sewage;sewage treatment;Sexual Partners;Signal Transduction;Site;social stigma;success;surveillance data;Testing;Time;tool;transmission process;Viral;viral detection;Viral Load result;virology;wastewater sampling;wastewater testing;Work

PROJECT_TITLE: Wastewater Sampling: A New Tool to Accelerate Ending the HIV Epidemic

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: NARRATIVE Hispanic/Latino (H/L) individuals are at increased risk for Alzheimer’s disease and related dementias (ADRD) but are less likely to participate in research. Leveraging our existing community engaged research network – the Engaging Communities of Hispanics/Latinos for Aging Research (ECHAR) Network, the proposed work aims to (1) refine and (2) disseminate a culturally responsive multimedia “toolkit” for use in engaging and recruiting Hispanic/Latino adults into AD/ADRD research, monitoring its reach and uptake via various methods, including a phone-based risk calculator. Along these lines, we aim to develop a risk registry that we will leverage for (3) collection of behavioral data and (4) blood specimens that will allow us the workflow and pilot data necessary to begin characterizing the relationships of these variables in a diverse sample of H/Ls.

PI_NAMEs: MEDINA, LUIS D (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Adult;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoproteins;Behavioral;Biological;Biological Markers;Blood specimen;blood-based biomarker;Cardiovascular Diseases;Cities;clinical phenotype;Clinical Trials;cognitive function;Collection;Color;Communication;Communities;community engaged research;community engagement;community partners;daily functioning;Data;data repository;data resource;dementia risk;density;design;Development;Effectiveness;evidence base;Exclusion;Frequencies;Funding;Goals;health care availability;health literacy;heterogenous data;Hispanic;hispanic community;Hispanic Populations;Hypertension;Individual;Institution;Institutional Racism;Knowledge;Language;Latino;Latino Population;life span;Linguistics;Methods;Monitor;multidisciplinary;Multimedia;neuroinflammation;Not Hispanic or Latino;Outcome;Pathway interactions;personalized approach;Phase;Phenotype;Population;precision medicine;psychologic;Race;Random Allocation;recruit;Registries;Research;research study;Resources;Rest;Risk;Risk Factors;Sampling;social;socioeconomics;Spanish/English;Stress;stressor;Telephone;Trust;United States;United States National Institutes of Health;uptake;volunteer;Work

PROJECT_TITLE: A Precision Engagement Approach with Hispanics/Latinos for Alzheimer’s Disease Research: ECHAR-PE


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Spatially informative genomics platforms, such as spatial transcriptomics and single cell imaging mass cytometry, are the new frontiers of single cell omics. However, the bioinformatics challenges are outstanding and the applications in clinical treatment are lacking. In this R01 renewal project, we aim to develop multiple cutting edge computational methods for understanding tumor-tumor microenvironment interaction in order to predict drug reposition and patient survival using these new data types.

PI_NAMEs: GARMIRE, LANA X (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: accurate diagnosis;Address;Adopted;Algorithms;Architecture;Area;Artificial Intelligence;Award;Bioinformatics;Biological;Biological Assay;cancer cell;cancer diagnosis;cancer heterogeneity;Cancer Patient;cancer therapy;career;Cell Communication;Cells;cellular imaging;Characteristics;Chemotherapy and/or radiation;Clinical;clinical application;Clinical Treatment;Communities;Complex;computer framework;Computer Models;Computing Methodologies;cost;Cytometry;Data;Data Analyses;Development;Diagnosis;Disease;drug repurposing;effective therapy;Engineering;Epigenetic Process;Foundations;frontier;Funding;gene environment interaction;Genes;Genetic;genomic platform;Genomics;graph neural network;Head;Hematoxylin and Eosin Staining Method;Heterogeneity;Histopathology;Human;Image;Image Cytometry;Imaging Techniques;improved;In Situ;innovation;insight;Investigation;Link;Malignant Neoplasms;Methods;Mission;multi-scale modeling;multimodality;multiscale data;Neck;Neural Network Simulation;novel;novel drug combination;novel therapeutics;outcome prediction;patient prognosis;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physiologic pulse;Population;population health;Positioning Attribute;precision drugs;precision oncology;Precision therapeutics;Printing;Productivity;Prognosis;Property;Proxy;Publications;Recommendation;Research;Research Personnel;Resistance development;response;Sampling;Scientist;Series;single-cell RNA sequencing;sound;Stains;success;Technology;technology platform;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;transfer learning;Treatment outcome;tumor;tumor heterogeneity;tumor microenvironment;Work

PROJECT_TITLE: Cancer precision medicine through spatially informative single cell image and transcriptomics data analysis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Substance use disorders affect several million people in the United States every year, create significant economic burden, and cause tremendous suffering at the person, family, and societal levels. This proposal aims to investigate the dynamic interplay between pediatric substance use (a risk factor for substance use disorders) and rate of neuromelanin accumulation (a proxy for dopamine function) for the first time. Thus, this application seeks to identify a brain mechanism (dopamine function) that could be targeted in youth by future treatments in order to prevent onset of substance use disorders.

PI_NAMEs: PERLMAN, GREG  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 16 year old;6 year old;Address;adolescent substance use;Adult;Affect;Age;age group;age related;Alcohol consumption;alcohol expectancy;alcohol exposure;Anabolism;biological sex;boys;Brain;Chickens;Childhood;Chronic;cohort;Complex;connectome based predictive modeling;Corpus striatum structure;Development;Disease;Dopamine;dopamine system;Economic Burden;egg;Enrollment;Etiology;Expectancy;Family;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;girls;Goals;Growth;Habits;high risk;Human;imaging modality;imaging study;indexing;Investigation;Longitudinal Studies;Magnetic Resonance Imaging;Marijuana;marijuana use;Measures;Mediating;Mediator;Methods;Midbrain structure;Modeling;molecular imaging;National Institute of Drug Abuse;Neurobiology;neuromelanin;Neurons;novel;Pathway interactions;Patient Self-Report;Pattern;Pediatric cohort;Pediatric Research;Persons;Pharmaceutical Preparations;pleasure;Population;Positron-Emission Tomography;prevent;programs;prospective;Proxy;Radiation;Radiation exposure;Research;Research Priority;Rest;Rewards;Risk Assessment;Risk Factors;Role;Sampling;sex;Sex Differences;Signal Transduction;Source;substance use;Substance Use Disorder;Substantia nigra structure;Testing;theories;Time;time interval;time use;tool;Traction;Translational Research;United States;Validation;Ventral Tegmental Area;Youth

PROJECT_TITLE: Neuromelanin MRI: A tool for non-invasive investigation of dopaminergic abnormalities in adolescent substance use.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Researching Effective Strategies to Prevent Opioid Death (RESPOND) model is a simulation model of OUD and OUD treatment delivery in a state. We use RESPOND to investigate the health benefits, costs, and cost-effectiveness of policy choices and interventions to expand OUD treatment. With this grant, we will use the model to investigate economic and equity impacts of policies regulating prescribing for medications for OUD and innovative care delivery models for people with OUD.

PI_NAMEs: LINAS, BENJAMIN P. (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Ambulatory Care;Black Populations;Buprenorphine;Calibration;Caring;Clinical;collaborative care;Color;Communities;Consolidated Framework for Implementation Research;cost;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Cost Measures;Costs and Benefits;Data;data infrastructure;Drug Prescriptions;Drug usage;Drug user;economic impact;economic value;Economics;Ensure;Epidemiology;Equity;Funding;Gender;gender disparity;Grant;Health;Health Benefit;health economics;health equity;implementation framework;implementation study;Imprisonment;improved;innovation;interest;Intervention;Investments;Justice;Kentucky;Latinx population;medication for opioid use disorder;men;Mental Health;methadone treatment;Methods;Modeling;models and simulation;National Institute of Drug Abuse;Needle-Exchange Programs;New York;novel;Ohio;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;people of color;Persons;Pharmaceutical Preparations;Policies;Population;Prescription opioid overdose;prevent;Public Health;Publishing;Race;racial disparity;Racial Equity;response;Service delivery model;Special Population;Structural Racism;telehealth;tool;Woman


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pain Research;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Opioid use disorder remains a significant public health crisis with poor clinical decision support- predicting use is still challenging and ineffectively accounts for the constellation of factors that play a role in escalation and/or dependence. We will apply a machine learning approach leveraging the diverse and equitable AllOfUs dataset which will integrate genomics, social, and clinical factors to predict development of opioid use disorder. Novel biomarkers will be elucidated to aid in future clinical support for these at-risk populations.

PI_NAMEs: GABRIEL, RODNEY ALLANIGUE (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Adult;Affect;Age;Body mass index;Chronic;chronic pain;chronic painful condition;Classification;Clinical;clinical care;Clinical Data;clinical decision support;clinically relevant;Code;Communities;Control Groups;Copy Number Polymorphism;Data;Data Set;Databases;Dependence;Development;Diagnosis;Enrollment;Ensure;Equity;Ethnic Origin;Exposure to;Family;Fibromyalgia;Future;Gender;Genetic Markers;genome sequencing;genome wide association study;genomic biomarker;genomic data;genomic profiles;Genomics;Geography;health equality;health equity;high risk;illicit opioid;improved;Individual;insight;interest;Machine Learning;machine learning model;machine learning prediction;Medical;Metadata;Methods;Minority;Modeling;multiple data types;neural network;novel;novel marker;opioid abuse;opioid epidemic;opioid mortality;opioid therapy;opioid use;opioid use disorder;Outcome;outcome prediction;Output;Pain;painful neuropathy;patient population;patient stratification;Patients;Performance;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Populations at Risk;Postoperative Pain;predictive modeling;prescription opioid;prescription pain reliever;Prevalence;Procedures;Public Health;Race;Recording of previous events;Research;Risk;risk prediction model;risk stratification;Sampling;sex;Single Nucleotide Polymorphism;social;Social Environment;social factors;Socioeconomic Status;Substance Use Disorder;Techniques;time use;tool;Translations;Underrepresented Populations;United States;Variant;vector;Visualization;whole genome

PROJECT_TITLE: Predictive Models for Opioid Use Disorder Using Genomic, Social, and Clinical Factors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed research is relevant to public health because Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by heterozygous loss-of-function mutation of the MECP2 gene in girls without effective treatment. We propose to apply our DNA methylation editing tools to reactivate the silent wild type allele of MECP2 gene from the inactive X chromosome. Our success in demonstrating MECP2 reactivation and functional rescue in RTT animal model will pave the way for future clinical trials of MECP2 methylation editing in girls with RTT.

PI_NAMEs: BEDALOV, ANTONIO ;LIU, X. SHAWN (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: adeno-associated virus 9 delivery;Adult;Age;Alleles;Animal Model;Animals;bisulfite sequencing;Brain;Breathing;Cells;Cessation of life;Chimeric Proteins;Chromatin;Clinical Trials;Data;demethylation;detection sensitivity;Development;Disease;DNA Methylation;early childhood;effective therapy;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Epigenetic Process;Exhibits;experimental study;Face;Female;Future;Gene Mutation;Genes;Genetic;Genetic Transcription;genomic locus;girls;Heterozygote;Hindlimb;Histones;Human;human embryonic stem cell;Immune;Immune response;In Vitro;in vivo;Injections;Knockout Mice;Lead;Life;life span;limb movement;Link;loss of function mutation;Loss of Heterozygosity;male;Measures;Methods;Methyl-CpG-Binding Protein 2;Methylation;methylome;Modeling;mouse model;Mus;Mutation;nanoluciferase;neonatal encephalopathy;Neonatal Mortality;Neurodevelopmental Disorder;Neurologic Deficit;neuronal cell body;Neuronal Differentiation;Neuronal Dysfunction;Neurons;novel;Patients;Pattern;Phenotype;promoter;Proteins;Public Health;Reporter;Repression;Research;restoration;Rett Syndrome;reverse genetics;Severities;success;Symptoms;Testing;Therapeutic;Time;Tissues;tool;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Model;Transgenic Organisms;treatment strategy;Untranslated RNA;vector;Viral;whole genome;women patients;X Chromosome;X Inactivation

PROJECT_TITLE: MeCP2 reactivation from the inactive X chromosome as treatment for Rett syndrome

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: The Center for Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern (C-THAN) will catalyze innovation in diagnostic technologies through a model that enhances complementary strengths to build multidisciplinary partnerships across technology platforms, clinical, regulatory and commercialization domains relevant to the needs of low- and middle-income countries.

PI_NAMEs: ACHENBACH, CHAD J (contact);MCFALL, SALLY MAUREEN;MURPHY, ROBERT LEO

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Address;Adoption;Africa;African;AIDS related cancer;Award;Biomedical Engineering;Charge;Clinical;Clinical Research;clinical translation;Collaborations;commercialization;Communication;comorbidity;COVID-19 testing;design;Detection;Development;Devices;Diagnostic;diagnostic platform;diagnostic technologies;Ebola;Emerging Communicable Diseases;Emerging infection;Engineering;Evaluation;experience;Funding;Goals;Hepatitis B;HIV;HIV/AIDS;HIV/HCV;Home;Human immunodeficiency virus test;improved;Individual;Industrialization;Infection;innovation;International;Laboratories;Lassa Fever;Lateral;Libraries;low and middle-income countries;Maintenance;Mali;manufacture;Marketing;member;Modeling;Molecular;Monitor;Monkeypox virus;multidisciplinary;Needs Assessment;Nigeria;non-tuberculosis mycobacteria;Output;Physicians;Point of Care Technology;Principal Investigator;Process;Productivity;program dissemination;programs;prototype;Publishing;Research;Research Personnel;Resources;Rift Valley Fever;Scientist;Senegal;Site;skills;South Africa;Specimen;Sputum;Structure;synthetic biology;Tanzania;Technology;technology development;technology platform;technology research and development;Testing;Textbooks;Training;training opportunity;translational study;Translations;Tuberculosis;United Nations;United States National Institutes of Health;Universities;Validation;validation studies;Viral;Work;working group

PROJECT_TITLE: The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

PI_NAMEs: ACHENBACH, CHAD J (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Africa;Ally;Award;Biomedical Engineering;Caring;Chad;Charge;Clinical;Clinical Research;Collaborations;commercialization;Communicable Diseases;Communication;Complex;conflict resolution;Decision Making;Development;Devices;Diagnostic;diagnostic technologies;Doctor of Philosophy;Emergency Situation;Emerging Communicable Diseases;Engineering;experience;Funding;Goals;Grant;Health;HIV;HIV/AIDS;HIV/TB;Home;improved;Individual;infrastructure development;innovation;Institution;Lateral;Lead;Leadership;low and middle-income countries;Mali;Medical;Medical Device;Medicine;Mission;Modeling;Molecular;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;next generation;Nigeria;Office of Administrative Management;Persons;Physicians;point of care;Point of Care Technology;Process;programs;Public Health;Recording of previous events;Research;Research Design;Research Personnel;Research Training;Science;Senegal;Site;South Africa;Structure;synthetic biology;Tanzania;Techniques;Technology;technology platform;technology research and development;United States;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Administrative Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE: We will perform systematic validation of cell-free and exosomal microRNA biomarkers that we have already discovered for the early-detection of cancer, in large, multi-institutional, multi-national and ethnically diverse, prospective cohorts of patients with pancreatic cancers and precancerous lesions. Successful validation of these biomarkers will exert a substantial diagnostic and prognostic impact on the management of this fatal disease.

PI_NAMEs: GOEL, AJAY  (contact);VON HOFF, DANIEL D

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;advanced disease;Area Under Curve;biobank;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Blood;CA-19-9 Antigen;cancer biomarkers;cancer cell;cancer diagnosis;Cancer Etiology;cancer invasiveness;Cells;Cessation of life;Clinical;clinical diagnosis;clinical implementation;clinical translation;clinically significant;cohort;Development;Diagnosis;Diagnostic;Diagnostic Sensitivity;Diagnostic Specificity;diagnostic strategy;Disease;Early Diagnosis;Enrollment;ethnic diversity;ethnic minority population;Excretory function;exosome;extracellular vesicles;Funding;Genes;genome-wide;High grade dysplasia;high risk;Human;Imaging Device;improved;Individual;Institution;Intellectual Property;Intraepithelial Neoplasia;Lead;Legal patent;Lesion;Life;machine learning algorithm;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Messenger RNA;microRNA biomarkers;MicroRNAs;miRNA expression profiling;molecular marker;Monitor;Neoplasms;Non-Invasive Detection;Pancreas;pancreatic cancer patients;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;Participant;participant enrollment;Patients;Performance;Plasma;premalignant;prognostic;prospective;Prospective cohort;racial diversity;racial minority population;Resectable;response;Risk;sample collection;Screening for cancer;Serology;Serum;Specificity;Specimen;success;Survival Rate;Time;transcriptomics;tumor;Tumor Markers;Tumor-Derived;Untranslated RNA;Validation

PROJECT_TITLE: Exosome-based microRNA biomarkers for Non-invasive and Early Detection of Pancreatic Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Social Determinants of Health

PI_NAMEs: MCFALL, SALLY MAUREEN (contact)

PROJECT_TERMS: access restrictions;Address;Advisory Committees;Africa South of the Sahara;African;Anti-Retroviral Agents;antiretroviral therapy;Area;Award;Biological Assay;Biomedical Engineering;Calibration;Caring;Clinical;Collaborations;commercialization;community setting;comorbidity;Continuity of Patient Care;cost;Country;COVID-19 pandemic;design;Detection;Developing Countries;Development;Devices;Diagnosis;diagnosis design;Diagnostic;Diagnostic Errors;diagnostic platform;Disease;Electricity;Emerging Communicable Diseases;Engineering;Fostering;Funding;Funding Opportunities;Goals;Grant;Hepatitis B;HIV;HIV diagnosis;HIV drug resistance;HIV/AIDS;HIV/HCV;Home;improved;Incidence;Incubated;Infrastructure;innovation;Lateral;Leadership;low and middle-income countries;Maintenance;Mali;Malignant Neoplasms;Mediating;Medical;member;Mentors;Mentorship;Molecular;Monitor;National Institute of Biomedical Imaging and Bioengineering;Nigeria;non-tuberculosis mycobacteria;operation;Output;Performance;Persons;Pharmaceutical Preparations;point of care;Point of Care Technology;point of care testing;Positioning Attribute;Principal Investigator;Process;process optimization;programs;prototype;Public Health;RADx;RADx Tech;Recommendation;recruit;Reduce health disparities;Refrigeration;Request for Applications;Research;Research Personnel;Research Support;Resource-limited setting;Resources;Satellite Viruses;screening;Senegal;Services;Site;skills;South Africa;Strategic Planning;synthetic biology;Tanzania;Technology;technology development;Technology Transfer;Testing;Training;Tuberculosis;underserved community;United States National Institutes of Health;Universities;Update;user-friendly;Validation;Viral;Viral Load result;Water Supply;working group;Writing

PROJECT_TITLE: Technology Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project narrative: Bleeding and clotting complications after severe injury are very common and complicate the management of trauma patients. We will identify strategies to minimize these complications by focusing on restoring the health of the endothelium, the lining of blood vessels, which is an important way the body regulates blood clotting.

PI_NAMEs: COHEN, MITCHELL ;FREEMAN, KALEV ;NEAL, MATTHEW D (contact);YAFFE, MICHAEL B

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: acidic sphingomyelinase;Acidosis;activated protein C receptor;Address;Advanced Development;Affect;Automobile Driving;biobank;bis(monoacylglyceryl)phosphate;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Calcium;Catecholamines;Cell surface;Cells;Characteristics;Clinical;Coagulation Process;Complex;Critical Illness;Cues;cytokine;design;Development;Disease;Early identification;Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;Health;Hemorrhage;Hemorrhagic Shock;Hemostatic function;Homeostasis;Hospitals;Hypoxia;Image;Immune response;Immune system;Impairment;improved outcome;Inflammation;Inflammatory;Injury;innovation;Interruption;Investigation;Lead;MAP Kinase Gene;Mediator;metabolomics;Molecular;Morbidity - disease rate;mortality;multiple omics;Nature;novel;Organ;Organ failure;organ injury;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Peptide Initiation Factors;Perfusion;Permeability;Phenotype;Plasma;Pre-Clinical Model;Preclinical Testing;prevent;Process;prospective;Protein C;Proteomics;Randomized, Controlled Trials;Regulation;repair model;repair strategy;repository;Research;Research Personnel;response;restoration;Resuscitation;Risk;Role;role model;Sampling;Science;severe injury;Severities;Shock;Signal Pathway;Signal Transduction;Survivors;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;thromboinflammation;Thromboplastin;Thrombosis;thrombotic complications;tissue injury;Tissues;tool;transcriptomics;Transfusion;Transgenic Organisms;Trauma;trauma induced coagulopathy;Trauma patient

PROJECT_TITLE: Endothelial Dysfunction and Restoration in Trauma Induced Coagulopathy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE The percentage of bilingual learners in the US is expected to rise to 25% by 2030; Spanish is the second most common language in the US. The aims of this proposal are to identify cognitive mechanisms that optimize the success of language development in young Spanish-English bilinguals with developmental language disorders that affect 7.5% of the population, regardless of bilingualism status so as to help early identification and targeted remediation for bilinguals and linguistically-diverse learners with developmental language disorders.

PI_NAMEs: KOVELMAN, IOULIA  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Affect;after-school program;Age;Architecture;Basic Science;Behavior assessment;Behavioral;bilingualism;Brain;brain behavior;Child;Child Development;Clinical;clinically significant;Cognitive;cognitive function;Communities;Competence;Comprehension;Development;Developmental Delay Disorders;developmental neurobiology;Dorsal;Early identification;elementary school;Environment;Equilibrium;Exhibits;experience;Faculty;functional near infrared spectroscopy;Home;Hour;Image;improved;Individual Differences;innovation;Intervention;Judgment;Language;language comprehension;Language Development;Language Development Disorders;language impairment;language outcome;Linguistics;Link;Maintenance;Measures;neural;neural circuit;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;Pattern;Population;Process;Production;remediation;Reproducibility;Risk;School-Age Population;Schools;self organization;Semantics;skills;Source;Spanish;Spanish/English;Specificity;Stream;success;syntax;System;Testing;theories

PROJECT_TITLE: Bilingual Children with DLD: A Neurodevelopmental Perspective

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Social Determinants of Health

PROJECT_TERMS: Adoption;Caregivers;Characteristics;Chicago;Clinical;Clinical Data;Clinical Investigator;Clinical Research;clinical research site;Collaborations;Communicable Diseases;Communities;Community Health Networks;community setting;comorbidity;COVID-19 diagnostic;COVID-19 point of care;data repository;Dedications;Development;Devices;Diagnosis;Diagnostic;Emerging Communicable Diseases;Engineering;Enrollment;Evaluation;experience;Faculty;FDA Emergency Use Authorization;Fogarty International Center;Funding;Goals;Grant;Health;HIV;HIV/AIDS;Home;Human;Illinois;Individual;Infrastructure;innovation;Institution;International;Laboratories;Leadership;low and middle-income countries;Mali;manufacture;medical schools;Methodology;National Institute of Biomedical Imaging and Bioengineering;Nigeria;novel;pandemic disease;Participant;Patients;Perception;Performance;Pilot Projects;point of care;Point of Care Technology;programs;Protocols documentation;prototype;Public Health;Public Health Practice;RADx;RADx Tech;Research;research clinical testing;Research Design;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Reverse Transcriptase Polymerase Chain Reaction;Sampling Studies;Senegal;Services;Site;social culture;South Africa;success;Tanzania;Technology;Technology Assessment;technology development;technology research and development;Testing;Training;Training Programs;Translations;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;uptake;usability;Validation;validation studies;virtual repository;Work

PROJECT_TITLE: Clinical Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PI_NAMEs: PALAMOUNTAIN, KARA  (contact)

PROJECT_TERMS: Adoption;Africa;Anti-Retroviral Agents;Botswana;Brazil;Cambodia;China;Clinical;clinical implementation;commercialization;Communities;comorbidity;Country;Dedications;design;Detection;Development;Diagnostic;Diagnostic Equipment;digital health;Educational process of instructing;Emerging Communicable Diseases;Ensure;Environment;Evaluation;experience;Feedback;Foundations;global health;Goals;Hepatitis B;Hepatitis C;HIV;HIV diagnosis;HIV drug resistance;HIV/AIDS;HIV/HCV;Home;Human Papillomavirus;improved;Incidence;India;Infrastructure;innovation;Interview;Kenya;Lesotho;low and middle-income countries;Malawi;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;manufacture;Marketing;Mediating;meetings;Molecular;Monitor;Mozambique;Namibia;Needs Assessment;Nigeria;non-tuberculosis mycobacteria;Patients;Pharmaceutical Preparations;point of care;Point of Care Technology;point-of-care diagnostics;Policy Maker;Process;prototype;Research;sample collection;Sampling;Satellite Viruses;Schools;screening;Services;South Africa;Specific qualifier value;Students;success;Swaziland;Tanzania;Technology;Training;Tuberculosis;Uganda;United States National Institutes of Health;Universities;Vietnam;Viral Load result;Zambia;Zimbabwe

PROJECT_TITLE: Dissemination Core - The Center for Innovation in Point-of-Care Technologies for HIV/AIDS and Emerging Infectious Diseases at Northwestern University (C-THAN)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: St. Louis

ORG_NAME: IMMUNOPHOTONICS, INC.

ORG_STATE: MO

PHR: PROJECT NARRATIVE Immunophotonics proposes this IND-enabling research project for the development of a polymeric synthetic biomaterial, IP-001, to potentiate a systemic immunotherapy via microwave thermal tumor ablation for treatment of hepatocellular carcinoma. IP-001 aims to reduce recurrence post ablation and prolong overall survival in patients by eliciting immune control over systemic micro-metastases. It revolutionizes the field of interventional radiology by transforming it into a means of early immunotherapy that can be applied broadly to other solid cancers without disruption to the standard of care.

PI_NAMEs: LAM, SIU KIT  (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: Ablation;advanced breast cancer;Aftercare;analytical method;animal data;anti-PD-1;Antigen-Presenting Cells;Antigens;Biocompatible Materials;Biological Markers;Biopolymers;Biotechnology;Blood;Blood Chemical Analysis;Breast Cancer Patient;Cancer Etiology;CD8-Positive T-Lymphocytes;Cells;Cessation of life;chemical property;Chemistry;Cirrhosis;Clinical;Clinical Trials;Collaborations;comorbidity;Contralateral;Data;Dendritic Cells;Development;Diabetes Mellitus;Disease remission;Dose;efficacy testing;Eligibility Determination;Excision;Feedback;Frequencies;genetic analysis;Goals;Grant;Growth;Health;Hepatitis;Immune;Immune checkpoint inhibitor;Immune system;Immunity;Immunologic Stimulation;immunoregulation;Immunotherapy;Implant;improved;Injections;Interferon Type II;Intervention;Interventional radiology;Investigational Drugs;Investigational New Drug Application;Lesion;Liver;liver cancer model;Liver Dysfunction;liver function;liver transplantation;long term memory;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;meetings;Melanoma;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methodology;Methods;Micrometastasis;microwave ablation;microwave electromagnetic radiation;Modality;Modeling;Monitor;mouse model;Mus;Neoplasm Metastasis;neutrophil;nonalcoholic steatohepatitis;Normal Range;novel;Obesity;Oncology;Operative Surgical Procedures;Outcome;Patients;PD-1 inhibitors;Pharmaceutical Preparations;Phase;Phase I/II Clinical Trial;physical property;Polymers;preclinical safety;Preclinical Testing;predictive marker;Primary carcinoma of the liver cells;Progression-Free Survivals;Rattus;Recurrence;Recurrent tumor;Regional Disease;Reporting;research clinical testing;Research Personnel;Research Project Grants;response;Safety;safety testing;scale up;Serum;Small Business Innovation Research Grant;Soft tissue sarcoma;Solid;standard of care;Survival Rate;Switzerland;synergism;T cell response;Thermal Ablation Therapy;Time;Toxic effect;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;Tumor Immunity;United States;Universities;Validation

PROJECT_TITLE: Development of polymeric synthetic biomaterial IP-001 to potentiate asystemic immunotherapy of hepatocellular carcinoma via thermal ablation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(11)B]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PHR: PROJECT NARRATIVE This project brings together leading international researchers uniquely positioned to uncover the neurobiological risks of adolescent alcohol use and distinguish these from the consequences of alcohol use in adolescence and across the lifespan. Our aims will be achieved through robust analyses of the landmark Adolescent Brain Cognitive Development Study, as well as harmonization of this study with other international datasets covering the full adult lifespan. Outcomes from this project will have the potential to provide novel neurobiological targets for medication development, as well as alcohol preventions and interventions informed by neuroscience.

PI_NAMEs: MEWTON, LOUISE  (contact);SQUEGLIA, LINDSAY

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Accounting;Address;Adolescence;Adolescent;adolescent alcohol risk;Adolescent Development;Adult;Age;Aging;alcohol consequences;Alcohol consumption;alcohol effect;alcohol intervention;alcohol prevention;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;biobank;Biometry;Brain;brain health;causal model;Cessation of life;Chronic;Code;cognitive development;cognitive training;cohort;Data;data harmonization;Data Set;design;Development;developmental disease;Developmental Process;Disabling;drinking;drinking onset;Follow-Up Studies;Growth;Hospitalization;human old age (65+);Image;Incidence;innovation;International;Knowledge;Life;life span;Longitudinal cohort study;Machine Learning;Maps;Memory;Methodology;Methods;middle age;model design;Modeling;Neurobiology;neurodevelopment;neuroimaging;neuroregulation;Neurosciences;novel;older adult;open data;Outcome;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Positioning Attribute;Probability;Psychopathology;Recurrence;Research;Research Personnel;Risk;Sample Size;Sampling;substance use;symptomatology;Techniques;Testing;Time;Twin Multiple Birth;underage drinking;young adult

PROJECT_TITLE: Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Palliative Care;Patient Safety;Social Determinants of Health;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative As both immunotherapy and cannabis use are becoming more widespread therapeutic options in oncology, the demand for prospective data on the effects of cannabis among those being treated with immunotherapy for cancer will continue to grow. Our proposed project fills a gap by providing crucial long-term data on the role of cannabis use on benefits and harms among those receiving immunotherapy. Overall, this study will have a sustained impact on the science of cancer symptom management and ultimately improve patient care and safety.

PI_NAMEs: ASHARE, REBECCA  (contact);MEGHANI, SALIMAH H.;NUGENT, SHANNON MADORE

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Adverse effects;Anxiety;Area;Biological;Blood Cell Count;cancer immunotherapy;Cancer Patient;Cancer Science;cancer therapy;Cannabis;checkpoint therapy;Clinical;Clinical Data;Cognitive;cognitive task;Collaborations;Computerized Medical Record;Consumption;Cross-Sectional Studies;CSF3 gene;Data;deprivation;Disease;Disease Progression;Disparity;disparity reduction;District of Columbia;Dizziness;Ecological momentary assessment;electronic data;evidence base;Exhibits;Fatigue;Funding;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;health equity;Immune checkpoint inhibitor;immune function;Immune system;Immunologic Markers;Immunology;Immunooncology;immunoregulation;Immunotherapy;improved;improvement on sleep;indexing;Individual;Interdisciplinary Study;Interleukin-2;Interleukin-6;Knowledge;Legal;Link;liver function;Longitudinal Studies;Malignant Neoplasms;marijuana use;marijuana use disorder;marijuana user;Measures;Medical Marijuana;Memory impairment;Mental Health;Methods;Moods;multidisciplinary;NCI-Designated Cancer Center;neighborhood disadvantage;Oncologist;Oncology;Outcome;Pain;Patient Care;Patient Outcomes Assessments;patient safety;patient subsets;Patients;Performance;Persons;Prevalence;programs;progression marker;prospective;Prospective, cohort study;Qualifying;Quality of life;Renal function;Reporting;Research;response;Role;Sampling;Schedule;Science;secondary outcome;Severities;side effect;Site;Sleep;Sleep disturbances;social health determinants;Solid;substance misuse;Surveys;symptom management;Symptoms;Telephone;Testing;Therapeutic;Therapeutic Uses;Time;TNF gene;tumor;tumor progression;virtual

PROJECT_TITLE: Assessing benefits and harms of cannabis use in patients treated with immunotherapy for cancer: a prospective cohort study


NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Stroke;Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE In the US almost 800’000 people have a stroke every year leaving more than half of these people with permanent arm and hand motor deficits (hemiparesis). Unfortunately, the only option available today is intense physical therapy, which improves motor performances but is not effective for many with moderate and severe post-stroke arm hemiparesis. In this project we will test the efficacy of a novel neurostimulation system targeting the cervical spinal cord in combination with physical therapy to increase strength, ameliorate motor function and improve motor recovery in people with chronic post-stroke hemiparesis.

PI_NAMEs: CAPOGROSSO, MARCO  (contact);WEBER, DOUGLAS J

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: Activities of Daily Living;Affect;American;Animal Model;arm;arm function;Articular Range of Motion;Authorization documentation;Axon;Behavior Therapy;Behavioral;Brain;Cervical;Cervical spinal cord structure;Cervical spine;Chronic;chronic stroke;Clinical;Clinical assessments;Clinical Trials;Collaborations;comparative efficacy;Data;design;Devices;dexterity;efficacy evaluation;efficacy study;efficacy testing;Electroencephalography;Feasibility Studies;Fiber;Forearm;Goals;grasp;H-Reflex;Hand;hemiparesis;Hemiplegia;Home;Human;human data;human subject;Implant;implantation;Implantation procedure;improved;Individual;Industrialization;Institutional Review Boards;Intervention;Joints;Label;Lateral;Leg;Lesion;Link;Locomotion;long term recovery;Measures;Motivation;Motor;motor control;motor deficit;motor function improvement;motor impairment;Motor Neurons;motor recovery;Movement;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel;off-label use;Operative Surgical Procedures;Pain;Paralysed;Paresis;Patients;Performance;Persons;Phase;Physical therapy;Physiologic pulse;post stroke;preclinical study;primary outcome;prospective;Quality of life;Randomized;recruit;Residual state;safety testing;secondary outcome;Sensory;social;Spinal;Spinal Cord;Spinal cord injury;statistics;Stroke;stroke hemiparesis;stroke rehabilitation;stroke survivor;Support System;synergism;System;targeted treatment;Testing;Therapeutic;Time;Torque;Training;Validation;Weight-Bearing state;white matter damage;With laterality;Work

PROJECT_TITLE: Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke Hemiplegia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project is relevant to human health because it will combine structural biology and biophysics with conventional cellular neuroscience techniques to test a key hypothesis about how neurotransmitter receptor organization regulates synaptic strength, plasticity, and human disease states. In the future, the detailed structural and functional understanding of glutamate receptor clustering that results from this work will inform the design of therapeutics for targeting the organization of glutamate receptors. Therefore, the proposed research is relevant to the NIH mission of protecting and improving human health by understanding the processes that control synaptic neurotransmitter receptor regulation in unprecedented detail.

PI_NAMEs: HALE, WILLIAM DYLAN (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adhesions;Affinity;antagonist;Binding;Binding Sites;Biochemical;Biochemistry;Biology;Biophysics;Brain;career;Cations;Cell Adhesion Molecules;Cell surface;Cells;Complex;Cryoelectron Microscopy;Data;design;Disease;Disinhibition;Electrophysiology (science);excitatory neuron;Excitatory Synapse;Exhibits;expectation;extracellular;Functional disorder;functional outcomes;Future;Genetic;Glutamate Receptor;Glutamates;Goals;Health;Human;human disease;improved;innovation;insight;Interneurons;Learning;light microscopy;Membrane;Memory;Mental disorders;Mentors;Methods;Mission;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;N-terminal;Nervous System Disorder;neuronal pentraxin;Neurons;neuropsychiatric disorder;Neurosciences;Neurotransmitter Receptor;particle;Parvalbumins;Pathology;pharmacologic;Physiology;Positioning Attribute;postsynaptic;presynaptic;prevent;Process;Property;Proteins;receptor;Regulation;Research;response;Role;Schizophrenia;stoichiometry;structural biology;Structural Models;Structure;Surface;Synapses;synaptic function;Synaptic plasticity;Techniques;tenure track;Testing;Therapeutic;therapeutic development;therapeutic target;Training;Transgenic Mice;United States National Institutes of Health;Work

PROJECT_TITLE: Structure-guided functional analysis of GluA4-NPTX2 interaction during PVIN homeostatic scaling


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: Tucson

ORG_NAME: CERIA THERAPEUTICS, INC.

ORG_STATE: AZ

PHR: NARRATIVE  Inflammation and oxidative stress are major factors in the pathogenesis of acute lung injury and progression to ARDS, for which no pharmacological treatments have been approved. CTX-002 is a special formulation form of CNP-miR146a for intra-tracheal administration, which prevents inflammation and lung injury, and is nontoxic upon systemic delivery in rodents. These efforts described in this proposal are intended to complete IND- enabling studies to file an IND for clearance to begin first-in-human clinical trials, based on recommendations from the FDA from our Pre-IND meeting.

PI_NAMEs: JACKSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Abdomen;Acute Lung Injury;Acute Respiratory Distress Syndrome;Admission activity;Adverse effects;Anti-Inflammatory Agents;Award;Biological Assay;Bleomycin;Cells;Cerium;cerium oxide nanoparticle;Cessation of life;Chemical Exposure;Chemistry;Clinical;Clinical Trials;Collaborations;comparison control;COVID-19 pandemic;Critical Care;Cyclophosphamide;cytokine;Development;Dose;Drug Kinetics;Early Diagnosis;Etiology;Failure;Family suidae;Feedback;Fibrosis;first-in-human;Formulation;Gases;Generations;Goals;Hospital Mortality;Hour;IL8 gene;Impairment;improved;Incidence;Inductively Coupled Plasma Mass Spectrometry;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Injury;Interleukin-6;Intravenous;intravenous administration;Laboratories;Life;Lipopolysaccharides;Lung;Lung Compliance;Lung infections;lung injury;Macrophage;manufacture;Maximum Tolerated Dose;Measures;Mechanical ventilation;Mechanics;methicillin resistant Staphylococcus aureus;MicroRNAs;mimetics;Miniature Swine;Modeling;Molecular;Morbidity - disease rate;mortality;Mustard Gas;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Nuclear;Operative Surgical Procedures;Organ;Outcome;Oxidative Stress;Particle Size;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Phase;phase 2 study;Pilot Projects;Poison;pre-Investigational New Drug meeting;Preparation;prevent;Prevention;Process;Production;Property;Pulmonary Fibrosis;pulmonary function;Rattus;Reactive Oxygen Species;Recommendation;Recovery;recruit;Research;Respiratory System;Rodent;Safety;scale up;Sepsis;side effect;Small Business Innovation Research Grant;supplemental oxygen;systemic inflammatory response;Therapeutic;Tissues;Toxic effect;Toxicology;Toxin;Trauma;Ventilator-induced lung injury

PROJECT_TITLE: Targeting inflammation and oxidative stress to treat acute lung injury with CNP-miR146a


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: From 2023 to 2028, the KIdney Disease in children data Management and Analysis Center (KIDMAC) will continue to perform as the Data Coordinating Center of the Chronic Kidney Disease in Children (CKiD) cohort study. We will provide leadership in study design, coordination and conduct, data management, analytical methodology and quality assurance; thereby enhancing the scientific scope of CKiD. KIDMAC investigators have expertise in research design, coordination, data management, quality assurance/control and epidemiological and biostatistical methods for complex longitudinal and survival data from cohort studies.

PI_NAMEs: NG, DEREK K (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 17 year old;Adolescence;Adult;Age;aged;Ancillary Study;Behavior;Biochemistry;Biological;Biological Markers;Biometry;Biosocial;Biostatistical Methods;bone health;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;CBL gene;Cellular Phone;Child;Childhood;Chronic Kidney Failure;Cities;Clinical;clinical center;Clinical Markers;Clinical Protocols;cohort;Cohort Studies;Collaborations;Communication;Communities;Complement;Complex;Computers;Contractor;Custom;Data;data acquisition;Data Analyses;Data Analytics;Data Collection;Data Coordinating Center;data management;Data Management Resources;Data Set;design;Development;Discipline;Disease Progression;electronic data;electronic data capture system;Electronic Health Record;Electronics;Ensure;Epidemiologic Methods;Epidemiology;epidemiology study;Equation;functional decline;Funding;Genetic;Growth;Height;illness length;Impairment;improved;Incidence;Infrastructure;innovation;Institution;interest;Iohexol;Joints;Kansas;Kidney Diseases;Laboratories;Lead;Leadership;Link;Machine Learning;machine learning method;machine learning prediction;Measurement;Medical Records;meetings;Metabolic;method development;Methodology;Methods;Minnesota;Modeling;Modification;Monitor;nephrogenesis;Nephrons;Neurocognitive;Online Systems;organizational structure;Outcome;Participant;Pediatric Hospitals;Persons;Philadelphia;Population;Predictive Value;programs;Prospective Studies;Protocols documentation;Public Health Schools;Publications;quality assurance;Questionnaires;recruit;Renal function;Reporting;repository;Research;Research Activity;Research Design;Research Personnel;Risk Factors;Role;Sampling;Social Functioning;Source;Specimen;Standardization;Statistical Methods;Subgroup;Surveys;System;Technology;Testing;transmission process;U-Series Cooperative Agreements;undue influence;Universities;Validation;Visit;Well in self;Work;Writing;young adult

PROJECT_TITLE: The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases;Rehabilitation;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The proposed research is relevant to public health because it focuses on increasing the uptake of the human papillomavirus (HPV) vaccine in young cancer survivors, a vulnerable population at high risk for developing new cancers (such as cervical and anal cancer) caused by persistent HPV infection. An effective vaccine exists that can prevent these cancers, but HPV vaccine uptake is low among young cancer survivors (fewer than 1 in 4 have received the vaccine). This proposed research will provide important information that can be used to implement new strategies to increase the uptake of the HPV vaccine among young cancer survivors, and thus is relevant to the NIH’s mission to reduce illness and disability.

PI_NAMEs: KLOSKY, JAMES ;LANDIER, WENDY  (contact)

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: 17 year old;Address;Adolescent;Age;age group;Area;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Caring;Centers for Disease Control and Prevention (U.S.);childhood cancer survivor;chronic infection;Clinic;Clinical;Cluster randomized trial;Confidence Intervals;Coupled;design;disability;Disease;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;Eligibility Determination;Ensure;evidence base;Evidence based intervention;Feedback;follow-up;future implementation;General Population;Geography;Guidelines;Health behavior;health care delivery;health disparity;Health Personnel;Health Promotion;Healthcare;high risk;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hybrids;Immune;Immunization;implementation efforts;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Intervention;intervention program;Knowledge;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Mission;Morbidity - disease rate;National Cancer Institute;Neoplasms;Odds Ratio;Oncogenic;Oncology;Outcome;Outcomes Research;Parents;Patients;Pediatric Oncology;peer;Persons;Population;post intervention;prevent;Prevention;Primary Care;Provider;provider communication;Public Health;Randomized;Recommendation;Recovery;Research;Research Priority;Sampling;Secondary Cancer Prevention;Series;skills;success;Survivors;survivorship;Testing;therapy development;Time;Training;United States National Institutes of Health;Vaccination;Vaccines;Vulnerable Populations;young cancer survivor

PROJECT_TITLE: Implementation of a Provider-Focused Intervention for Maximizing HPV Vaccine Uptake in Young Cancer Survivors receiving Follow-Up Care in Pediatric Oncology Practices: A Cluster-Randomized Trial


NIH_SPENDING_CATS: Bioengineering;Data Science;HIV/AIDS;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: San Diego

ORG_NAME: MODULO BIO, INC.

PHR: Project narrative There are over 600 neurodegenerative diseases affecting nearly a billion people around the world, and many of these diseases like ALS (commonly known as Lou Gherig’s Disease) are fatal and have no cure or effective treatment. There has not been significant work to find elements that are shared or unique across diseases using new large-scale datasets now available, and standard computational approaches cannot distinguish correlation from causation, slowing down drug development. Our proposed research will develop tools to combine vast amounts of data in a computational system which captures causality, to find drug targets we can test in the lab using patient cells, and to extend a pipeline that can then be expanded to multiple other diseases, contributing to drug development across neurodegenerative diseases, thus accelerating progress towards potential cures. 1

PI_NAMEs: SACHS, KAREN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acceleration;Active Learning;Address;Affect;Antisense Oligonucleotides;Area;Biological;Biological Assay;Biological Models;Biology;causal model;causal variant;cell type;Cells;Classification;Clinical;Coculture Techniques;comparative;Computer Models;Coupled;Data;data framework;data integration;data platform;Data Set;Databases;design;Disease;disease model;Disease Pathway;disorder subtype;Disparate;drug development;Drug Targeting;effective therapy;Elements;Etiology;flexibility;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Goals;Health;heterogenous data;Image;in silico;In Vitro;in vitro Model;in vivo;Individual;individual patient;Induced Neurons;induced pluripotent stem cell;insight;Knowledge;large scale data;Learning;learning network;Link;machine learning framework;machine learning model;Methods;Microglia;Modeling;Molecular;mouse model;multidimensional data;multiple datasets;Mus;Nerve Degeneration;network models;Neurodegenerative Disorders;Neuroimmune;neuroimmunologic disease;Neurons;neuroprotection;new therapeutic target;Organism;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;personalized medicine;Persons;Physiological;predictive modeling;Research;risk variant;Science;screening;single-cell RNA sequencing;small molecule;stem cell model;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;Validation;Work

PROJECT_TITLE: Implementing a coupled system of integrative ML modeling and data validation for elucidating microglial therapeutic targets in neurodegenerative disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Neurosciences;Precision Medicine;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Recent evidence suggests that blood can act as a surrogate for brain tissue to predict alcohol dependence status and drug treatments in mice, but it is unknown whether this is true for humans. These studies will identify molecular biomarkers that can be obtained in a minimally invasive way through blood sampling and offer an accessible precision medicine approach that will facilitate patient stratification, treatment selection, and patient monitoring, and hence have the potential to greatly improve AUD management and outcomes.

PI_NAMEs: FERGUSON, LAURA BROCKWAY (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Aftercare;Air;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol risk;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Area;Award;Behavior assessment;Biological;Biological Assay;Biological Markers;Biometry;Blood;Blood specimen;Blood Tests;Brain;brain tissue;Caring;Chronic;Classification;Clinical;Clinical assessments;Clinical Management;Clinical Trials;Data;design;Development;Diagnosis;Diagnostic;differential expression;Digoxin;Disease Management;Disease Progression;drinking;Drug Prescriptions;Escalator;Ethanol;Ethics;Event;experience;experimental analysis;Experimental Designs;experimental study;Exposure to;forest;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;genomic profiles;Goals;Health Personnel;Heavy Drinking;Heterogeneity;Human;human subject;improved;Individual;infancy;insight;Institutional Review Boards;Joints;Knowledge;longitudinal analysis;Medical;Messenger RNA;Methods;minimally invasive;model building;Modeling;Molecular;molecular marker;Monitor;mouse model;Mus;Naltrexone;next generation sequencing;Observational Study;optimal treatments;Outcome;Pathway interactions;Patient Monitoring;patient population;patient stratification;Patients;personalized medicine;Pharmacologic Substance;Pharmacotherapy;Physicians;Population;potential biomarker;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;Process;Prognosis;programs;prospective;protocol development;Proxy;Publishing;recruit;Research;responders and non-responders;response;Risk;risk prediction;RNA;Rodent;Sampling;Screening procedure;Selection for Treatments;Solid;Specimen;statistics;success;Techniques;Technology;Testing;Therapeutic;Time;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;translational potential;treatment effect;treatment response;vapor;Withdrawal;Work

PROJECT_TITLE: RNA biomarkers for alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Urologic Diseases

ORG_CITY: RICHBORO

ORG_NAME: UROGENIE LLC

PHR: Lay Summary Uroflowmetry or the measurement of the speed of urine flow rates remains the most common tool by which urologists can assess the health of the lower urinary tract. Current methods of me asurement are time consuming, rely upon paper records, and are limited to the office. We offer a new system that can be used on any regular toilet in the office or home that will transmit the flow data wirelessly into the electronic medical record.

PI_NAMEs: FEDOROVSKY, ROMAN  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Adult;Biofeedback Training;Bluetooth;Capital;Cellular Phone;Child;Clinic;cloud based;Computer software;Computerized Medical Record;Confidence Intervals;Consumption;Data;Data Element;Detection;detector;Devices;digital;Dryness;electronic medical record system;Electronics;falls;Female;Funding;Future;Grant;graphical user interface;health assessment;Home;Image;Income;Individual;innovation;insight;Institutional Review Boards;interest;Interview;literacy;Location;Lower urinary tract;lower urinary tract symptoms;male;Marketing;Measurement;Measures;Medical Records;Meniscus structure of joint;Methods;Microprocessor;Monitor;Names;Nature;Output;Pain;Paper;Participant;participant interview;Patient Selection;Patients;Pharmaceutical Preparations;Physicians;Printing;Process;Protocols documentation;prototype;Provider;Questionnaires;R44 grant;Records;Saline;Scanning;Services;Small Business Innovation Research Grant;software development;Speed;System;Tablet Computer;Tablets;Testing;testing services;Time;tool;Tooth structure;transmission process;United States National Institutes of Health;urinary;Urine;Urodynamics;Urologist;Variant;Water;Weight;wireless;Work

PROJECT_TITLE: Digital Uroflowmetry for Office and Home

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-R(11)]


ORG_CITY: STATE UNIVERSITY

ORG_NAME: BIOSTRATEGIES, LC

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Currently, there are no approved treatments for MPS IIIA (also known as Sanfilippo A syndrome), a genetic disorder that causes progressive degeneration of the brain and other organs leading to death during the teenage years. This study is designed to advance the development of a gene therapy that enables patients to produce functional enzyme that is delivered to the brain and other organs to treat the symptoms of the disease. If successful, this treatment is expected to provide the first and only treatment for this debilitating disease.

PI_NAMEs: CRAMER, CAROLE L.;PATTADA, SHIVAKUMAR DEVAIAH (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Advanced Development;Affinity;Age;Animal Model;Antibody Response;Behavior;Binding;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Carbohydrates;Caregivers;Cell surface;Central Nervous System;Cessation of life;Childhood;Chimeric Proteins;Clinical;commercialization;comparison control;Complex;Defect;design;design and construction;Development;Disease;Dose;early adolescence;effective therapy;efficacy evaluation;efficacy testing;emerging adult;enzyme replacement therapy;Enzymes;experimental study;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;Glycolipids;Glycoproteins;Heart;Heparitin Sulfate;Histopathology;In Situ;In Vitro;in vivo;Infiltration;interest;Intrathecal Injections;Intravenous;intravenous administration;Intraventricular;Intraventricular Injections;Kidney;lead candidate;Lectin;Life;Liver;Longevity;Lysosomal Storage Diseases;Mammalian Cell;manufacturing cost;Methods;Modeling;mortality;mouse model;Mucopolysaccharidoses;Mucopolysaccharidosis III A;Mus;Musculoskeletal System;Nerve Degeneration;novel;novel strategies;Organ;Other Genetics;Pathology;Patients;Penetration;Peripheral;Phase;Phenotype;preclinical efficacy;prevent;Price;Production;Research;Ricin;Risk;Safety;Sales;Serotyping;Small Business Innovation Research Grant;symptom treatment;Symptoms;System;Systemic Therapy;Teenagers;Therapeutic;Therapeutic Effect;Tissues;Transfection

PROJECT_TITLE: Gene Therapy that Systemically Produces Brain-penetrating Replacement Enzyme for MPS IIIA (Sanfilippo A Syndrome)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: Project Narrative The proposed study will be the first large scale RCT in the US assessing effectiveness and cost effectiveness of XR-B versus SL-B with individuals in a carceral setting who are re-entering community. The study will be significant because most individuals with OUD do not receive buprenorphine treatment while in jail, thereby substantially raising their likelihood of relapse to drug use, overdose death, and re-incarceration when they are released. Finally, understanding how to expand acceptance of extended-release and sublingual buprenorphine in jails, has far-reaching implications for expanding treatment access in this population.

PI_NAMEs: BLUE, THOMAS ;GORDON, MICHAEL SCOTT (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accidents;Administrator;Adoption;Adult;Adverse event;Award;Back;Buprenorphine;buprenorphine treatment;care coordination;Cessation of life;Cities;Clinical Trials;Communities;community reentry;comparative effectiveness trial;compare effectiveness;Conduct Clinical Trials;Continuity of Patient Care;cost;Cost Analysis;cost effectiveness;County;Crime;Day Care;design;dosage;Dose;Dropout;Drug usage;Effectiveness;effectiveness evaluation;Ensure;Event;experience;Formulation;Funding;Health Services Accessibility;Health system;Healthcare;HIV risk;illicit opioid;Imprisonment;Individual;Injectable;Injections;innovation;Intake;Intervention;Jail;Longterm Follow-up;Medical;medication compliance;medication for opioid use disorder;Mental Health;metropolitan;Needles;open label;Opioid;Opioid agonist;opioid use;Overdose;overdose death;overdose risk;Patient Preferences;Patient Self-Report;Pharmaceutical Preparations;Phase;physical conditioning;Policy Maker;Population;preference;Pregnant Women;primary outcome;Prisons;Procedures;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;rearrest;Regulation;reincarceration;Relapse;Research;Research Design;Research Personnel;Risk;Risk Behaviors;risk minimization;Safety;secondary outcome;sexual risk behavior;Site;Subcutaneous Injections;Suboxone;substance use;Surveys;System;Time;timeline;Toxicology;Urine;Visit

PROJECT_TITLE: A comparative effectiveness trial of sublingual versus extended-release buprenorphine with individuals leaving a carceral setting

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Multiple etiologies variously contribute to the clinical syndrome of mild cognitive impairment and dementia presumed due to Alzheimer’s disease, but the many factors that give rise to symptoms are difficult to quantify at the level of the individual. A comprehensive panel of imaging and plasma biomarkers will improve the likelihood that etiologies beyond Alzheimer’s disease can be detected. Such individual-level characterization will greatly impact diagnostic accuracy, and prediction of symptom course and response to experimental therapies.

PI_NAMEs: BIBER, SARAH ;DICKERSON, BRADFORD C;FOROUD, TATIANA M.;JOHNSON, STERLING C (contact);KUKULL, WALTER ANTHONY;MORMINO, ELIZABETH ;OKONKWO, OZIOMA C;RABINOVICI, GIL DAN;RIVERA-MINDT, MONICA G.;WOLK, DAVID A

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Accounting;Address;adjudication;Age of Onset;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;astrogliosis;Autopsy;Biological Assay;Biological Markers;Blood Vessels;Brain;burden of illness;Classification;Clinical;Clinical Data;clinical heterogeneity;Cognitive;cognitive change;cohort;Cohort Studies;Collection;Consensus;Data Collection;Data Set;data sharing;Dementia;design;Diagnosis;diagnostic accuracy;diagnostic development;Disclosure;Disease;Ecosystem;Enrollment;Ensure;Etiology;fluorodeoxyglucose positron emission tomography;Foundations;Functional disorder;Future;Genetic;Glial Fibrillary Acidic Protein;Heterogeneity;Image;imaging biomarker;imaging study;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Individual;Infrastructure;Investigational Therapies;Ischemia;ischemic lesion;Joints;Label;Lewy Bodies;Link;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Metabolic;Methods;Microvascular Dysfunction;mild cognitive impairment;mixed dementia;Modeling;Morphology;Motion;MRI Scans;Nerve Degeneration;neurobehavioral;neuropathology;Outcome;Participant;Pathology;patient engagement;Patients;Pattern;Perfusion;Phenotype;Plasma;Positioning Attribute;Positron-Emission Tomography;Predisposition;Process;programs;prospective;protein TDP-43;Protocols documentation;recruit;Research;Resource Sharing;Resources;response;serial imaging;Severities;shared repository;Site;Source;Standardization;success;Symptoms;Syndrome;System;tau Proteins;Techniques;therapeutic development;Time;tool;treatment trial;Underrepresented Populations;Validation;Vascular Diseases;Visual;Work

PROJECT_TITLE: ADRC Consortium for Clarity in ADRD Research Through Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-B(02)]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Motor disorders cause debilitating impacts on movement across adolescence and adulthood. Understanding genetic mechanisms that shape the development and maintenance of neural networks for body movements is crucial for identifying effective therapies for the treatment of motor disorders. Research in this proposal uses advanced genetic, imaging, and behavioral tools available in animal model systems, providing me with a strong foundation to become an independent scientist investigating motor regulation and dysfunction.

PI_NAMEs: HASSINAN, CERA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Adolescence;Adult;Animal Model;Animals;awake;Behavior;Behavioral;Biological Models;Caenorhabditis elegans;Calcium;cell type;central pattern generator;Collection;Complex;connectome;course development;Defect;Development;Disease;disease model;disorder control;effective therapy;Environment;Excision;experimental study;flexibility;Foundations;Functional disorder;fundamental research;Gait;Genetic;genetic analysis;Goals;Growth;Health;Human;human disease;Image;Imaging Device;Individual;Injury;innovation;insight;Invertebrates;Investigation;juvenile animal;Knowledge;Life;life span;Locomotion;Locomotor adaptation;Maintenance;Maps;mature animal;migration;model organism;Molecular;Motor;Motor Activity;motor control;motor disorder;motor impairment;Motor output;mouse model;Movement;Movement Disorders;Mus;Nematoda;Nervous System;Nervous System Disorder;Nervous System Trauma;neural;neural circuit;neural network;Neurologic Dysfunctions;Neurons;Newborn Infant;optogenetics;Pathway interactions;Pattern;Periodicity;Phase;Play;Postdoctoral Fellow;pre-doctoral;Predisposition;Process;programs;receptor;receptor function;recruit;Regulation;Research;Research Personnel;Research Training;Risk;Role;Scientist;sensory feedback;Shapes;skill acquisition;skills;Societies;Solid;Specific qualifier value;Study models;supportive environment;Swimming;System;Techniques;Time;tool;Training;Vertebrates;Walking;WNT Signaling Pathway;Work

PROJECT_TITLE: Neural basis of movement in health and disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

PHR: Project Narrative Cells must control when and how much of a protein is made; dysregulation leads to human disease. The start of translation, which defines the protein to be synthesized, is the rate-limiting step and therefore is targeted by regulatory complexes that tune protein production up or down. Here, I apply biochemical, biophysical, and structural approaches to illuminate molecular mechanisms that underlie translation initiation and its control – a pillar of human cellular function.

PI_NAMEs: LAPOINTE, CHRISTOPHER PAUL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: base;Binding;Biochemical;Biological Assay;Biophysics;Cell Physiology;Cells;Collaborations;Complement;Complex;Cryoelectron Microscopy;Data;Development;developmental disease;Dimensions;Disease;Embryo;Ensure;eukaryotic initiation factor-5B;Event;Foundations;Future;genetic regulatory protein;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Hour;Human;human disease;In Vitro;Kinetics;Length;Link;Malignant neoplasm of lung;Malignant Neoplasms;malignant neurologic neoplasms;Mentors;Messenger RNA;Molecular;Molecular Conformation;Multiprotein Complexes;Mutation;Nervous System;Nervous System Disorder;Outcome;particle;Phase;Postdoctoral Fellow;Process;Production;Protein Biosynthesis;Proteins;reconstitution;recruit;Regulation;Research;Research Personnel;Resolution;Ribosomes;Role;single molecule;Site;Spectrum Analysis;structural biology;Structure;therapeutic development;Time;Training;Translation Initiation;Translational Repression;Translational Research;Translations;Viral Proteins;Virus Diseases;Work

PROJECT_TITLE: From one end to the other: dynamics of human translation initiation and its control

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PI_NAMEs: HARRINGTON, CHERISE BALDWIN;KUMAR, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TITLE: Understanding Perceptions of HIV Risk, PrEP, and PrEP use among African American Women Attending an HBCU


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Interventions that increase plasticity and regeneration after spinal cord injury (SCI) are improving, but little is known about the spinal cord neural systems that would be most effective to target such interventions. This project both identifies the spinal cord neural cell types and synaptic mechanisms that would be most effective to target such interventions and establishes an artificial intelligence (AI)-based platform for fast, reliable and unbiased quantification of motor recovery in rodents. Our experimental scrutiny at both the neural and behavioral levels establishes a critical foundation for developing a prominent research program and securing independent award funding studying the spinal cord circuits important for sensorimotor function and recovery following SCI.

PI_NAMEs: ABRAIRA, VICTORIA EUGENIA GUADALUPE (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 3-Dimensional;Anatomy;Artificial Intelligence;Award;Behavior;behavior influence;Behavioral;Behavioral Assay;behavioral outcome;Biological Markers;career development;cell type;Complex;cutaneous sensory neurons;Data;defined contribution;Development Plans;Elements;Ensure;experimental study;Foundations;Funding;Gait;Genetic;genetic approach;Goals;Grant;Growth and Development function;improved;Injury;injury recovery;insight;Institution;Interneurons;Intervention;kinematics;Label;Laboratories;Leg;Link;Liquid substance;Locomotion;Mediating;Mentors;Mentorship;Mission;Modeling;Motor;motor behavior;Motor Neurons;motor recovery;mouse genetics;Movement;Muscle;National Institute of Neurological Disorders and Stroke;Natural regeneration;neural;Neurons;Output;Parvalbumins;Pattern;Performance;Play;Population;Positioning Attribute;Privatization;Probability;Process;programs;Proprioceptor;Publishing;Records;Recovery;Recovery of Function;Rehabilitation therapy;Research;response;Rodent;Role;Secure;Sensorimotor functions;Sensory;Sensory Process;Shapes;Site;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Structure;success;Synapses;synergism;System;Tactile;Technology;Testing;Therapeutic Intervention;Three-Dimensional Imaging;tool;Touch sensation;Training;United States National Institutes of Health;Visualization

PROJECT_TITLE: A new mechanistic and technological framework for uncovering the spinal cord neural systems important for functional recovery after injury


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Hazardous drinking and anxiety co-occurrence among Latinx persons in the United States poses a major public health concern. The proposed research aims to study the potential for microaggressions (MAs) – brief, subtle forms of everyday discrimination due to racial/ethnic status – as a culturally-specific antecedent to maintained and exacerbated alcohol use motivation, hazardous drinking, and anxiety experiences among Latinx hazardous drinkers and explore mediational processes and moderators in the MA-hazardous drinking and anxiety experiences relations that will inform future intervention and prevention efforts for this neglected health disparities group. Moreover, we seek to elucidate if MAs are distinct from, and more impactful than, non- discriminatory daily stressors and overt racism on the proposed outcomes.

PI_NAMEs: REDMOND, BROOKE Y (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Academic support;Adult;advanced analytics;Affect;Alcohol consumption;alcohol craving;alcohol misuse;alcohol use disorder;Alcohols;Anxiety;Anxiety Disorders;anxiety sensitivity;anxiety symptoms;Area;career development;Caring;catalyst;Chronic;Clinical Investigator;clinical training;comorbidity;Complex;coping;design;Development;Diagnostic;Discrimination;Disease;Distress;drinking;Ecological momentary assessment;Equipment and supply inventories;Esthesia;ethnic identity;Ethnic Origin;Ethnic Population;Evaluation;experience;Exposure to;Feeling;Female;Fostering;Frequencies;Funding Mechanisms;Future;Goals;hazardous drinking;Health;Health behavior;health disparity;health disparity populations;health inequalities;improved;Individual;Intention;Intervention;Investigation;Knowledge;Latinx;Latinx population;Leadership;Link;male;Memory;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;microaggression;Minor;Minority;minority stress;Modeling;Motivation;Nature;neglect;non-verbal;novel;Outcome;Participant;Pathway interactions;personalized approach;Persons;Prejudice;Prevention;Process;prospective;Public Health;Race;racial discrimination;racial population;racism;Reporting;Research;research data dissemination;Research Design;Research Personnel;resilience;Risk Factors;Role;Sampling;skills;Smoking;Smoking Behavior;stem;Stress;Stressful Event;stressor;Subgroup;Symptoms;Testing;Thinking;Time;time use;Training;Translational Research;United States;verbal;Work

PROJECT_TITLE: Latinx Hazardous Drinkers: Evaluating Microaggressions

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]