NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Neurodevelopmental disorders are common in the population, representing a significant burden in all aspects of life and society. Studies aimed at identifying underlying genetic causes and mechanisms of these disorders will lead to a better understanding of the underlying biological mechanisms and, in turn, facilitate development of improved diagnostic methods and potential treatments.

PI_NAMEs: DENNIS, MEGAN Y (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;Address;autism spectrum disorder;autistic children;Biological;Biological Assay;Brain;Candidate Disease Gene;Categories;causal variant;Cell Cycle;Cell Proliferation;cell type;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;comorbidity;Confocal Microscopy;cost;Coupled;Data;de novo mutation;Defect;Development;Developmental Gene;Diagnostic;Diagnostic Procedure;Disease;Drops;Early Intervention;Early treatment;Embryo;Etiology;Exhibits;experimental study;Fetal Development;Fishes;Future;gene function;Gene Mutation;gene-editing approach;Genes;Genetic;Genetic Markers;Genetic Risk;genetic variant;genome editing;genome sequencing;Genomic approach;Goals;Growth;Heterozygote;Human;Image;improved;in vivo;Individual;individuals with autism spectrum disorder;knock-down;Knock-out;Language;Larva;Lead;Life;loss of function;Loss of Heterozygosity;Macrocephaly;Measures;Megalencephaly;Methods;Microinjections;Missense Mutation;Modeling;Molecular;Mus;mutant;Mutation;neural;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurons;novel;Organoids;Orthologous Gene;Pathogenicity;Patients;Phenotype;Population;proband;Prognosis;PTEN gene;Publishing;rapid test;Recurrence;Reporting;Reproduction;Research;single-cell RNA sequencing;small molecule;Societies;transcriptome sequencing;Validation;Variant;variant of unknown significance;Work;Zebrafish

PROJECT_TITLE: Parallel assessment of neurodevelopment genes implicated in autism using zebrafish

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;HIV/AIDS;Human Genome;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative The Administrative Core provides financial and administrative oversight, and facilitates communication between  the program projects and service cores. As such, the core plays a key role in the success of the program, which  is focused on understanding how viral and host long noncoding RNAs contribute to herpesvirus-associated  disease and cancer.

PI_NAMEs: RENNE, ROLF F (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Archives;Awareness;Bioinformatics;Biology;Biometry;Biostatistics Core;Budgets;Cell Line;ChIP-seq;chromatin isolation by RNA purification sequencing;Clinical;Communication;Communities;Complement;Consultations;Core Facility;cost;crosslinking and immunoprecipitation sequencing;Data;data exchange;data sharing;Disease;DNA;DNA analysis;DNA sequencing;Educational Activities;Educational workshop;Ensure;Event;Florida;Fostering;Funding;gammaherpesvirus;Genomics;Goals;graduate student;Herpesviridae;Human Resources;Institution;laboratory facility;Leadership;Malignant Neoplasms;Manuscripts;meetings;Mission;Monitor;Plasmids;Play;Postdoctoral Fellow;Preparation;Productivity;programs;Protocols documentation;Publications;Reagent;recombinant virus;Recombinants;Reporting;Research;Resources;Role;Sampling;Schedule;Scientist;Secure;service utilization;Services;Site;sound;Students;success;synergism;Training;Training Support;transcriptome sequencing;Travel;tumorigenesis;Universities;Untranslated RNA;Viral;virus genetics;web page;web site

PROJECT_TITLE: "Core A" Administrative Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Histoplasma capsulatum is a primary pathogen that infects approximately 500,000 individuals per year in the U.S., and is a significant source of morbidity and mortality. The identification and characterization of fungal effectors of virulence will significantly advance our understanding of how this organism causes disease.

PI_NAMEs: SIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Affinity Chromatography;Apoptosis;Apoptotic;Binding;Biological;biological adaptation to stress;Biology;Body Temperature;C-terminal;Cell Death;Cells;Chemicals;CRISPR/Cas technology;Cysteine;Cystine;Cytolysis;cytotoxicity;Data;Defect;density;differential expression;Disease;disulfide bond;Elements;Elongation Factor;Exhibits;experience;experimental study;falls;Family;fascinate;fungus;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;genetic approach;Genetic Transcription;Genome;Goals;Growth;Histoplasma;Histoplasma capsulatum;human pathogen;Immune;Immune response;improved;Individual;Infection;Inhalation;Insecta;insight;Knock-out;Knockout Mice;Label;Laboratories;Macrophage;Mammals;Mass Spectrum Analysis;Microbe;Molds;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Open Reading Frames;Organism;pathogen;Pathogenesis;Pathway interactions;Pattern;Phagosomes;Phase;Phosphorylation;Play;Predisposition;Proliferating;Protein Family;Protein Secretion;Proteins;Publishing;Research;Resistance;response;reverse genetics;ribosome profiling;Role;Scheme;Sequence Homology;Signal Transduction;Soil;Source;Stress;Time;tool;Toxin;Transcend;Transcript;transcription factor CHOP;transcriptome;transcriptome sequencing;Translations;Virulence;Virulence Factors;virulence gene;Work;Yeasts

PROJECT_TITLE: Role of secreted cystine-knot proteins in Histoplasma-host interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: Project Narrative In the next project period, Core B will provide computational biology and bioinformatics services to Projects 1, 2, and 3. Core B will also develop new comprehensive next generation sequencing analysis pipelines to expedite data-to-interpretation times for P01 investigators, develop new project-specific software for Projects 1, 2, and 3, and continue training junior P01 investigators in computational biology and bioinformatics.

PI_NAMEs: FLEMINGTON, ERIK K (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS related cancer;analysis pipeline;arm;ATAC-seq;automated analysis;Bioinformatics;bioinformatics resource;Biological Sciences;Biology;Biomedical Research;Biomedical Technology;career;ChIP-seq;Clinical;Communities;comparative;Complex;Computational Biology;Computational Science;computer cluster;computer program;Computer software;computerized data processing;Computing Methodologies;Custom;Data;Data Analyses;data standards;Dedications;Development;Educational process of instructing;experience;Florida;Foundations;gammaherpesvirus;Goals;Health;Herpesviridae;high end computer;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Resources;improved;Individual;Infrastructure;inter-institutional;Investigation;Kaposi Sarcoma;Lymphoma;Malignant Neoplasms;Modeling;mouse model;Murine herpesvirus 68;Mus;Nature;next generation;next generation sequencing;Oncogenic;operation;Persons;Positioning Attribute;Progress Reports;Publications;Research;Research Personnel;Research Project Grants;Resources;response;RNA;Science;Sequence Analysis;Services;Site;skills;Software Tools;Solid;Technology;Time;tissue culture;tool;Training;transcriptome sequencing;Universities;Untranslated RNA;Viral;viral RNA;Work

PROJECT_TITLE: "Core B" Viral RNA-seq and bioinformatics Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Plant nectar-feeding is essential for survival and reproduction for many mosquito species, and mosquitoes locate sugar sources by using their sensitive olfactory system. Trap-and-kill systems that exploit the nectar-feeding behaviors have shown to be an effective control intervention, but we don't know which odorants in the plant scent that mosquitoes find attractive, or how they process this information in their olfactory system. Using Aedes aegypti mosquitoes, we will characterize the genes involved in the odorant reception of nectar source odors and determine the mechanisms by which this olfactory input is processed in the brain, thereby providing new attractant lures and tools for mosquito control.

PI_NAMEs: AKBARI, OMAR SULTAN;PITTS, RONALD JASON;RIFFELL, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Aedes;Affect;Anopheles Genus;Arboviruses;base;Behavior;behavior test;Behavioral;Behavioral Assay;Biological Assay;Blood;Brain;Calcium;Chemicals;comparative;contrast enhanced;CRISPR/Cas technology;Culex (Genus);Culicidae;Data;Detection;Development;Discrimination;Disease;Drosophila genus;Effectiveness;Environment;experimental study;feeding;Feeding behaviors;Female;Flowers;Flying body movement;Fruit;gamma-Aminobutyric Acid;Gas Chromatography;Gene Targeting;Genes;genetic approach;genome editing;Goals;Image;Immune response;Insect Vectors;Insecticides;insight;Intervention;life span;Ligands;Link;Lobe;male;Mediating;Methods;Modeling;Mosquito Control;mutant;mutualism;neural;Neurons;Nutrient;Odorant Receptors;Odors;Olfactory Pathways;Olfactory Receptor Neurons;Oocytes;Orphan;Outcome;Pathway interactions;Peripheral;Persons;Physiological Processes;Plants;Play;Population;Process;programs;Publishing;Rapid screening;Reproduction;response;Role;Shapes;Smell Perception;Source;sugar;Surveys;System;Technology;Testing;tool;Variant;vector management strategies;Vectorial capacity;Volatilization;Work

PROJECT_TITLE: The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PHR: Narrative The Recombinant Virus Core C provides an efficient, quality controlled, and cost-efficient research core that generates recombinant gamma-herpesviruses with defined mutations. This core will support the identification of lncRNA-dependent phenotypes for the oncogenic herpesviruses KSHV, EBV, and MHV68.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Archives;Bacteria;Biology;Cell Line;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost efficient;CRISPR interference;CRISPR/Cas technology;design;Development;DNA Resequencing;DsRed;experience;Financial Support;Funding;gammaherpesvirus;Generations;Genes;Genetic Recombination;genome-wide;Genomics;Goals;Herpesviridae;Human Herpesvirus 4;Human Herpesvirus 8;innovation;Institution;Malignant Neoplasms;MicroRNAs;Mutagenesis;Mutagens;mutant;Mutation;Oncogenic;Phenotype;programs;Protocols documentation;Publications;recombinant virus;Recombinants;Research;Resource Sharing;response;Role;Services;Techniques;Training;Untranslated RNA;Viral;Viral Genes;Virus Diseases

PROJECT_TITLE: "Core C" Recombinant Virus Core


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

PHR: CORE D NARRATIVE The purpose of Core D (Clinical Sample and Tumorigenesis core) is to provide essential services for Projects 1, 2 and 3 that include clinical sample acquisition and storage (Aim 1), histological processing and diagnostics (Aim 2), and in vivo experimentation using humanized mouse, xenograft mouse, and murine virus tumorigenesis systems (Aim 3). Thus, Core D will aid in the overall goal of the program by utilizing modern in vivo techniques and tumorigenesis models to define the biological relevance of virus and host noncoding RNAs identified in Projects 1, 2 and 3.

PI_NAMEs: TIBBETTS, SCOTT A. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animals;B-Cell Lymphomas;Biological;Biological Assay;Biological Process;Biology;Cells;Clinic;Clinical;clinical diagnostics;Clinical Pathology;Collaborations;combat;defined contribution;Diagnostic;digital;Disease;experimental study;Future;gammaherpesvirus;Goals;Hematopathology;Histologic;Histology;Human;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Immune;In Situ Hybridization;In Vitro;in vivo;Infection;interest;Kaposi Sarcoma;Malignant Neoplasms;Modeling;Modernization;Mus;neoplastic cell;Pathology;Process;programs;sample fixation;Sampling;Scientific Advances and Accomplishments;Services;Stains;System;Techniques;transcriptome sequencing;tumor;tumor growth;tumorigenesis;Untranslated RNA;Virus;Virus Diseases;Work;Xenograft procedure

PROJECT_TITLE: "Core D" Clinical Sample and Tumorigenesis Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Much like armor, Gram-negative bacteria (e.g., Escherichia coli) have a unique outer surface that prevents the use of many antibiotics making infections caused by these organisms extremely difficult to treat. This proposal will help determine the molecular machinery used by Gram negatives to assemble their outer surface providing new opportunities for the development of novel therapies to fight multi-drug resistant bacterial infections.

PI_NAMEs: TRENT, MICHAEL STEPHEN (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;aqueous;Attention;Bacteria;Bacterial Infections;beta barrel;Biochemical;Biogenesis;Biological Models;Biology;cell envelope;Cells;Cessation of life;Clinical;Complex;Cytoplasm;Data;Dedications;design;Development;economic cost;Encapsulated;Energy-Generating Resources;Escherichia coli;Family;fighting;Future;Genetic;global health;Glycerophospholipids;Gram-Negative Bacteria;Healthcare;Homeostasis;Hydrophobicity;Infection;lipid transport;Lipids;lipophilicity;Lipopolysaccharides;Lipoproteins;Maintenance;member;Membrane;membrane assembly;membrane biogenesis;Membrane Lipids;Membrane Proteins;Methodology;Molecular;Molecular Chaperones;Monitor;Movement;Multi-Drug Resistance;new therapeutic target;novel;novel therapeutics;Organism;pathogen;Pathway interactions;Peptidoglycan;periplasm;prevent;protein complex;Proteins;Reporting;Resistance;Role;Side;Surface;System;Systems Analysis

PROJECT_TITLE: Synthesis and transport of outer membrane components across the Gram-negative cell envelope

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Dengue virus serotypes 1-4 cause disease of major importance worldwide, but there are no effective vaccines or therapies that can be safely administered to all populations at risk of infection. Primary DENV infections, as well as the only licensed vaccine, can elicit antibodies in unexposed individuals that can enhance subsequent DENV infection with a different serotype; however, following a secondary DENV infection, immunity typically broadens and the risk of severe disease is decreased, indicating that serotype cross-protective immune responses can indeed be generated. In this study, we will use cutting-edge serological and genomic sequencing technologies coupled with unique longitudinal sample sets from our long-standing cohort study in Nicaragua to investigate how secondary cross-protective antibodies and B cells are induced and maintained over time in order to guide improved strategies for vaccine design.

PI_NAMEs: HARRIS, EVA  (contact);LAVINDER, JASON JAMES

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Address;Antibodies;Antibody Repertoire;Antibody Response;Antibody-Dependent Enhancement;Antibody-mediated protection;B cell repertoire;B-cell receptor repertoire sequencing;B-Lymphocytes;bioinformatics pipeline;Biological Assay;Blood Vessels;Cell Compartmentation;Cellular biology;Child;Childhood;Circulation;climate change;Cohort Studies;Communities;Complex;Convalescence;convalescent plasma;Coupled;defined contribution;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Disease;Epidemiology;Evolution;Flavivirus;Frequencies;Future;Generations;Genomics;Human;human disease;Humoral Immunities;Immune;Immune response;Immunity;Immunoglobulin G;Immunologics;Immunology;improved;Individual;Infection;infection risk;innovation;Investigation;Licensing;Maintenance;Memory B-Lymphocyte;Monoclonal Antibodies;mosquito-borne;multidisciplinary;Neutralization Tests;neutralizing antibody;Nicaragua;novel;Persons;Plasma;Plasma Cells;Population;Populations at Risk;Predisposition;Primary Infection;Prospective, cohort study;Proteomics;Recombinants;recruit;Research;Resolution;response;Risk;Sampling;secondary infection;sequencing platform;Serology;Serotyping;Shapes;Sorting;Specificity;Standardization;stem;System;Techniques;Technology;Time;Vaccine Design;vaccine strategy;Vaccinee;Vaccines;Viral;Viral Antigens;virology;Virus;Virus Diseases

PROJECT_TITLE: The evolution of dengue virus-reactive circulating antibody repertoire

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROCKVILLE

ORG_NAME: AMERICAN SPEECH-LANGUAGE-HEARING ASSN

ORG_STATE: MD

PHR: According to the National Institute on Deafness and Other Communication Disorders (NIDCD), millions of people in the United States have a communication or related disorder. Thirty million people 12 years of age or older have hearing loss in both ears, 6–8 million people have some form of a language impairment, and 7.5 million people have a voice difficulty. The Lessons for Success program aims to increase the generation of research in Communication Sciences and Disorders by providing educational support and guidance to 150 of the most promising early-career scientists, which will lead to improvements in the communication health of millions people with communication or related disorders.

PI_NAMEs: ROGERS, MARGARET A. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 12 year old;Acculturation;Address;Award;base;career;career development;Career Mobility;Collaborations;Communication;Communities;Competence;Data;Databases;Development;Discipline;Disease;Ear;Education;Elements;Eligibility Determination;experience;Extramural Activities;Faculty;Faculty Workshop;field survey;Funding;Generations;Grant;Grant Review;health communication;hearing impairment;improved;Individual;innovation;Interdisciplinary Study;language impairment;Mentors;National Institute on Deafness and Other Communication Disorders;Outcome;Outcome Measure;Participant;Persons;Positioning Attribute;Preparation;Principal Investigator;Productivity;Program Evaluation;programs;Publications;Reporter;Reporting;Research;Research Personnel;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;skills;success;symposium;Training;United States;United States National Institutes of Health;Voice;Work;Writing

PROJECT_TITLE: Lessons for Success


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The opioid crisis has inflicted a tremendous socioeconomic burden and resulted in the countless loss of lives. In order to further initiatives geared towards resolving the opioid crisis with novel treatments, basic neurophysiological mechanisms that underlie pathological opioid behaviors need to be elucidated. The goal of this proposal is use combinatorial genetic, photometric, electrophysiological, and machine-learning based behavioral analysis to decode the behavioral and neural correlates of the heterogeneous mesolimbic dopamine system that regulate morphine response and associative learning in non-dependent and morphine-dependent mice.

PI_NAMEs: JUAREZ, BARBARA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;Academia;Acute;Advisory Committees;analytical tool;Association Learning;Attenuated;Behavior;Behavioral;behavioral pharmacology;Biomedical Research;Brain region;Calcium;career development;Cells;Cholecystokinin;Chronic;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Computational Technique;conditioned place preference;Corticotropin-Releasing Hormone Receptors;Coupled;CRISPR/Cas technology;Cues;Data Set;Dependence;design;Development;Dissociation;Dopamine;dopamine system;dopaminergic neuron;Dose;Economic Burden;Electrophysiology (science);Equity;experience;Exposure to;Fiber;functional loss;gamma-Aminobutyric Acid;Genes;Genetic;genetic approach;Glutamates;Goals;Heterogeneity;Implant;in vivo;Injections;Interneurons;Laboratories;Learning;Link;Machine Learning;maladaptive behavior;Measures;Medial;Mediating;Mentors;mesolimbic system;Methods;Morphine;Morphine Receptors;Motivation;mu opioid receptors;Mus;Mutagenesis;neural;neural correlate;neuroadaptation;Neurons;neurophysiology;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid use disorder;opioid withdrawal;optical fiber;Pathologic;Pharmaceutical Preparations;Phase;Photometry;Play;Principal Investigator;programs;Psychological reinforcement;Receptor Gene;Receptor Signaling;recruit;Regulation;Relapse;response;reward processing;Rewards;Role;sensor;skills;socioeconomics;Synapses;Technology;Training;Ventral Tegmental Area;Viral;virtual;Virus;Withdrawal;Work

PROJECT_TITLE: Dopamine circuit regulation of morphine reinforcement across the opioid exposure cycle


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Health Services;Neurosciences;Rehabilitation;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Older adults are the fastest growing segment of the population. While vision loss is common in this age group, information on the true prevalence of vision impairment (distance visual acuity impairment and contrast sensitivity deficits) and the impacts that these impairments have on daily function and quality of life is limited. The goal of this project is to determine how common these impairments are in women aged 80+ and the impact that they have on physical and mental well-being.

PI_NAMEs: GOWER, EMILY W (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Age;age group;aged;Aged, 80 and over;Aging;barrier to care;Behavioral;Blindness;care seeking;Caring;Cataract;Cellular Phone;Characteristics;Clinic;Clinical;Clinical Research;Cognitive;cohort;Communities;Contrast Sensitivity;cost;daily functioning;Data;data repository;depressive symptoms;Eye;Eyeglasses;falls;Fright;functional decline;Funding;Glass;Goals;Health;Health Care Costs;Health care facility;Health Care Seeking Behavior;health care service;health care service utilization;Health system;Home;Home visitation;hospitalization rates;human old age (65+);Impairment;improved;Individual;innovation;instrumental activity of daily living;Intervention;Interview;Knowledge;Life;Light;Link;Loneliness;Measures;Medical Records;Medicare claim;member;Mental Health;mortality;movie;older adult;Older Population;older women;Outcome;Patient Care;patient navigator;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Physical Function;Policies;Population;Population Study;Postmenopause;Prevalence;prospective;psychosocial;Public Health;Quality of life;Recommendation;Refractive Errors;Reporting;repository;Research;Role;social;social engagement;Social Interaction;Social support;Societies;Testing;uptake;Vision;Vision Tests;Visit;Visual Acuity;Visual impairment;Well in self;Woman;Women's Health

PROJECT_TITLE: Characterizing Vision Impairment and Its Impact on Independence in Older Adults

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Comparative Effectiveness Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The objective of this project is to create a new Clinical Center (Hub) organized by the Johns Hopkins Medicine Department of Emergency Medicine (JHM DEM) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The JHM Hub-and-Spoke network over 25 clinical sites in five states and Washington, DC, associated with 9 institutional partners with committed EMS systems. This program will facilitate patient recruitment and protocol execution for SIREN-sponsored clinical trials designed to improve outcomes for patients with neurologic, cardiac, respiratory, hematologic, and traumatic conditions.

PI_NAMEs: KELEN, GABOR D (contact);ROTHMAN, RICHARD E

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Cardiac;Censuses;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Data;design;Development;diversity and inclusion;Economically Deprived Population;Educational workshop;Emergency Care;Emergency medical service;Emergency Medicine;Emergency research;Enrollment;Ensure;Environment;Equity;ethnic minority;Ethnic Origin;experience;Faculty;flexibility;Funding;Future;gender minority;Grant;Health;Health system;Heart failure;Hematology;improved;improved outcome;Individual;inner city;innovation;Institution;Lead;Leadership;lung failure;Maryland;Medicine;Mentors;Mentorship;Minority;Mission;Multicenter Trials;Neurologic;novel therapeutics;Nurses;organizational structure;Outcome;Patient Recruitments;Patient-Focused Outcomes;Patients;Population;Positioning Attribute;Principal Investigator;Productivity;programs;prospective;Protocols documentation;Publications;quality assurance;Race;racial minority;Records;recruit;Research;Research Personnel;respiratory;response;Rural Population;Sepsis;service providers;Sexual and Gender Minorities;sexual minority;Site;socioeconomic disadvantage;Structure;success;System;Testing;tool;Training;Underrepresented Minority;Underrepresented Populations;underserved community;United States National Institutes of Health;Urban Population;Visit;Washington;Woman;working group

PROJECT_TITLE: Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Well-conducted multi-center emergency care research can benefit patients with acute illness and injury. Temple researchers collaborate with emergency medicine, pulmonary, neurology and trauma experts to conduct trials in hospitals in Philadelphia and the surrounding region aimed at improving the treatment of acutely ill and injured patients.

PI_NAMEs: GENTILE, NINA T (contact)

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Acute;acute care;Address;Adenovirus Vector;Adherence;Adult;African American;Agreement;Area;Award;Baltimore;Cardiac;Cardiopulmonary;Cessation of life;Child;Childhood;Cities;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;Country;County;COVID-19;COVID-19 pandemic;COVID-19 prevention;Data Coordinating Center;Delaware;disability;Discipline;Education;Emergency Care;Emergency Medicine;Emergency research;Emergency Situation;Emotional;Enrollment;Ethnic Origin;Evaluation;Faculty;Fellowship;Financial cost;Fostering;Funding;Future;Geographic Locations;Grant;Health Policy;Health Services;Health system;Hispanic Populations;Hospital Departments;Hospitals;improved;Informatics;injured;Injury;innovation;Institution;Language;Leadership;Lung;Maryland;Medicine;meetings;member;Minority Groups;minority patient;multidisciplinary;Neurologic;Neurology;New Jersey;New York;Nursing Services;operation;Outcome;participant enrollment;Patient Care;Patients;payment;Pennsylvania;Persons;Philadelphia;Population Heterogeneity;pre-clinical;Pre-hospital setting;Process;Productivity;Protocols documentation;Provider;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Support;Rewards;Role;Route;rural area;Shock;Site;social;Societies;Socioeconomic Status;Structure;suburb;surveillance study;symposium;synergism;System;Time;Training;Translating;Trauma;trauma centers;Traumatic Brain Injury;trial enrollment;United States National Institutes of Health;Universities;University Hospitals;vaccine trial;webinar;Work;working group

PROJECT_TITLE: Temple Strategies to Innovate EmeRgENcy Care Clinical Trials Network (Temple-SIREN)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: In mammals, the motor cortex plays a key role in the control of voluntary movements, but how neural activity in the motor cortex is related to movement remains poorly understood. In this project, we leverage powerful experimental methods or recording and perturbing neural activity across multiregional circuits in the brain to determine how neural activity is transformed at each processing stage between the motor cortex and the musculature. A synthesis of these data and computational modeling results will allow us to evaluate the validity of a leading model of movement control by the motor cortex to help us link neural activity to behavior.

PI_NAMEs: ECONOMO, MICHAEL NICHOLAS (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Area;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Biomimetics;Brain;brain machine interface;Brain region;Brain Stem;Cell Nucleus;cell type;Cells;Cognitive;cognitive process;Communication;Complex;Computer Models;Coupled;data modeling;Dedications;Dimensions;Evaluation;Exhibits;experimental study;flexibility;Genetic;Goals;hypoglossal nucleus;improved;Individual;Influentials;Learning;Link;Mammals;Maps;Mediating;Methods;Modeling;Motor;Motor Activity;motor control;Motor Cortex;Motor Neurons;Motor output;Movement;Movement Disorders;Mus;neural;neural circuit;neural patterning;Neurons;neurophysiology;Neurosciences;neurotransmission;next generation;nonhuman primate;optogenetics;orofacial;Outcome;Output;Pathway interactions;Pattern;Physiology;Play;Population;prevent;Primates;Production;response;Role;segregation;sensory feedback;Signal Transduction;Silicon;Space Models;Specificity;Spinal;Structure;System;Testing;Time;Tongue;tool;transmission process;Variant;Viral

PROJECT_TITLE: Linking Motor Cortex Activity and Movement in the Mouse Orofacial System

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The future of science and medicine depends upon perspectives from a diverse workforce that integrates social, racial, ethnic, and cultural differences into advancement. This proposal seeks to recruit, retain, and prepare underrepresented scholars for successful and diverse careers to enhance the biomedical sciences workforce.

PI_NAMEs: ERGUL, ADVIYE ;RINKER, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: MUSC IMSD

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE  Chimeric antigen receptor (CAR) T cell-based therapy revolutionized our approaches to cancer treatment. Current limitation of this transformative therapy is a poor efficacy against solid tumors because CAR T cells rapidly lose their viability and activity inside these tumors. Studies proposed here will characterize key regulatory mechanisms responsible for death and inactivation of the intratumoral CAR T and identify novel means to target these mechanisms to disrupt the immune suppressive tumor microenvironment and to increase the efficacy of anti-cancer CAR T immunotherapies against solid tumors.

PI_NAMEs: COHEN, MICHAEL S;FUCHS, SERGE Y (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: 25-hydroxycholesterol;Acidosis;Adenosine;Adoptive Cell Transfers;ADP ribosylation;anti-cancer;Antigens;beta-Transducin Repeat-Containing Proteins;Binding;cancer cell;cancer immunotherapy;cancer therapy;Cell Death;Cell Survival;Cells;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Cholesterol;Clinical;Clonal Expansion;combinatorial;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Development;Down-Regulation;Engineered Gene;Family member;Genes;Genetic;Hematologic Neoplasms;Human;Hypoxia;IFNAR1 gene;Immune;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;insight;Interferon Type I;Interferons;MAP Kinase Gene;Mediating;Mixed Function Oxygenases;Modeling;Mono(ADP-Ribose) Transferases;Mus;Myeloid-derived suppressor cells;novel;Nutrient;Pathway interactions;Patients;pharmacologic;Phosphorylation;Phosphotransferases;Protein Kinase;receptor;recruit;Regulatory T-Lymphocyte;Resistance development;response;Role;Solid Neoplasm;Stress;success;T cell therapy;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;treatment response;tumor;tumor microenvironment;Tumor-associated macrophages;Tumor-Derived;tumor-immune system interactions;type I interferon receptor;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Targeting immunosuppression of intratumoral CAR T cells

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Critical to success of clinical care and translational science is awareness by clinicians and researchers that all diseases are characterized by differences between women and men in epidemiology, pathophysiology, manifestations, progression, and response to treatment. The goal of Tulane Biomedical Research Center of Excellence in Sex-Based Precision Medicine (COBRE in SPM) is to develop a novel generation of highly qualified researchers proficient in the study of SPM as a fundamental step toward equity in health.

PI_NAMEs: KROUSEL-WOOD, MARIE ;MAUVAIS-JARVIS, FRANCK  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acceleration;Address;Affect;Age;Applications Grants;Area;Awareness;Behavior;Bioinformatics;Biological;Biology;Biomedical Engineering;Biomedical Research;career;career development;Centers of Research Excellence;Clinical;clinical care;clinical translation;Collaborations;Complex;COVID-19;Diagnosis;Disease;education research;Educational Curriculum;Educational workshop;Environment;Epidemiology;Equity;Exhibits;Fostering;Functional disorder;Funding;Gender;gender difference;Generations;Genes;Goals;Health;health determinants;Hormones;improved;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;investigator training;Leadership;male;medical schools;Medicine;men;Mentors;Methods;mortality;next generation;novel;Pilot Projects;Population Sciences;precision medicine;programs;Public Health Schools;Qualifying;Race;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;Role;Schools;Science;Science Enrichment;Scientist;Series;Severities;sex;Sex Differences;skills;social;social factors;social health determinants;Social Medicine;Social Sciences;Structure;Students;success;symposium;Time;Training;Translational Research;Translations;treatment response;Tropical Medicine;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: COBRE in Sex-Based Precision Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Precision Medicine

PI_NAMEs: MAUVAIS-JARVIS, FRANCK  (contact)

PROJECT_TERMS: Advisory Committees;Bioinformatics;Biological;Biology;Biometry;career;Centers of Research Excellence;Clinical Research;Communities;data management;Decision Making;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;effectiveness research;Experimental Designs;Feedback;Fostering;Foundations;Funding;Gender;Growth;improved;Infrastructure;innovation;interdisciplinary collaboration;Leadership;Medical;medical schools;meetings;Mentors;Methods;Monitor;National Institute of General Medical Sciences;Office of Administrative Management;Other Genetics;Performance;Pilot Projects;precision medicine;Process;Productivity;programs;recruit;Research;Research Personnel;Research Project Grants;Research Support;Secure;Series;sex;social health determinants;success;symposium;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Update;web site;Wood material


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dissemination and Implementation Research;Precision Medicine;Social Determinants of Health;Women's Health Research

PI_NAMEs: CROSSLIN, DAVID RUSSELL (contact)

PROJECT_TERMS: Adoption;Age;artificial intelligence method;base;Basic Science;Bioinformatics;Biology;biomedical informatics;Biometry;career;Cells;Center for Translational Science Activities;Centers of Research Excellence;Clinical;clinical decision support;clinical implementation;clinical practice;Clinical Sciences;clinically relevant;Communities;Complement;computing resources;Consultations;Data;Data Analyses;data management;Data Set;design;Development;Discipline;Doctor of Philosophy;Economics;effectiveness evaluation;effectiveness/implementation design;Electronic Health Record;Electronic Medical Records and Genomics Network;Epidemiology;Evaluation;evidence base;Fostering;Funding;Gender;gender difference;genetic variant;genome wide association study;Genomics;Genotype;Grant;hands-on learning;Haplotypes;health care availability;Health Resources;Impact evaluation;implementation measures;implementation study;implementation trial;improved;Informatics;Interdisciplinary Study;intersectionality;Intervention;Knowledge;Laboratories;Legal patent;Life Style;Link;longitudinal analysis;Louisiana;Machine Learning;medical schools;Medicine;Methodology;Methods;mid-career faculty;multidimensional data;multiple omics;National Human Genome Research Institute;next generation;novel;occupational hazard;Participant;Patient-Focused Outcomes;Peer Review;phenotypic data;Pilot Projects;population health;precision medicine;programs;protocol development;Publications;Quality Control;Race;Reporting;repository;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Scientist;sex;Sex Differences;social health determinants;social media;social stressor;Specialized Center;statistical center;Tissues;Training;Translational Research;United States National Institutes of Health;Universities;user centered design;Validation;Women's Health;Work

PROJECT_TITLE: Sex-Based Precision Medicine Research Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Estrogen;Immunization;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Precision Medicine;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: MCCOMBS, JANET ELAINE (contact)

PROJECT_TERMS: adaptive immune response;Adult;Affect;Antibodies;Automobile Driving;B-Lymphocytes;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Centers of Research Excellence;Data;Death Rate;design;Development;effective therapy;Estrogens;Exhibits;Female;Genes;Goals;Helper-Inducer T-Lymphocyte;Human;Immune;Immune response;Immune system;Immunotherapy;Infection;Inflammation;Inflammatory;Innate Immune Response;Klebsiella pneumoniae;Knowledge;Lead;Lung;Lymphocyte;Lymphoid;Lymphoid Cell;Macrophage;male;Mediating;memory CD4 T lymphocyte;Molecular;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Natural Killer Cells;neutrophil;Nosocomial pneumonia;novel;Outcome;Ovariectomy;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;patient population;Pneumonia;Population;precision medicine;Precision therapeutics;Predisposition;Primary Infection;Pulmonary Inflammation;Research;Research Project Grants;Resistance;resistant Klebsiella pneumoniae;resistant strain;response;sex;Sex Differences;single-cell RNA sequencing;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;Testing;Therapeutic;therapeutic development;therapy development;Tissues;Treatment Efficacy;Vaccination;vaccine efficacy;vaccine response;Vaccines;women versus men;Women's mortality;Work;γδ T cells

PROJECT_TITLE: Project 1 McCombs


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: YOSHIDA, YILIN X (contact)

PROJECT_TERMS: Acceleration;Accounting;Adolescent;Affect;aging population;Area;Atherosclerosis;Biological;Black Populations;Black race;black women;Blood Pressure;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Centers of Research Excellence;Characteristics;Classification;Cluster Analysis;cohort;comorbidity;Complement;Coronary Artery Risk Development in Young Adults Study;Deterioration;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diagnosis;disadvantaged women;Disease;Disease Outcome;Disease Progression;early onset;endothelial dysfunction;Environment;Epidemiologic Methods;Epidemiology;Estrogen deficiency;Exhibits;experience;Exposure to;Face;Female;Foundations;Functional disorder;Funding;Gestational Diabetes;Goals;Gonadal Steroid Hormones;hands-on learning;Health;Health Disparities Research;Heart;Heterogeneity;Hormone imbalance;improved;Incidence;Individual;Inflammation;Insulin Resistance;intergenerational;Knowledge;learning strategy;Life Cycle Stages;life span;Lipids;Longitudinal cohort;low socioeconomic status;Machine Learning;Measures;men;Menopause;Mentored Clinical Scientist Development Program;Mentors;Metabolic;middle age;Midlife women;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;Obesity Epidemic;Pathogenesis;Patients;Phenotype;Polycystic Ovary Syndrome;Population;Population Study;precision medicine;Prediabetes syndrome;Predisposition;Premature Menopause;Prevalence;Prognosis;programs;Qualifying;reproductive;Research;research based learning;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Risk Factors;risk prediction;Running;sex;Sex Differences;sex disparity;Social Behavior;Socioeconomic Status;Solid;Subgroup;Testing;Training;United States National Institutes of Health;unsupervised clustering;Vascular Diseases;White Women;Woman;women versus men;Women's Role;Work;young adult

PROJECT_TITLE: Project 3 Yoshida


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Exposure to early-life adversity is a significant source of risk for poor developmental outcomes in young children, and is unequally distributed across groups, with minoritized people experiencing the greatest levels of adversity leading to gaps in mental and physical health. This proposal will test if Promoting First Relationships (PFR), an evidence-based 10-week home visiting program, delivered within a primary care setting, will operate as a protective factor against cellular aging in young children as measured by telomere length and epigenetic aging clocks. We will also evaluate the effectiveness of PFR with two additional sessions of PFR in Primary Care to enhance sensitive caregiving and parenting for low-income families in the context of primary care.

PI_NAMEs: DOW-SMITH, CARRIE ;OXFORD, MONICA L (contact);SHALEV, IDAN

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Accounting;Address;adverse childhood events;Adverse event;aging clocks;Biological;Blood;caregiver depression;Caregivers;caregiving;Caring;Cell Aging;Cell division;Child;Child Behavior;Child Rearing;Childhood;Chromosomes;Color;Communities;Conceptions;cost;Development;disability;Discrimination;Disease;disparity reduction;dosage;Dryness;Early Intervention;early life adversity;effectiveness evaluation;emotion regulation;Emotional;Enrollment;Epigenetic age;epigenetic aging;epigenetic clock;Event;evidence base;experience;Exposure to;Family;family support;follow-up;Generations;hallmarks of aging;health disparity;healthy lifestyle;Heritability;Home visitation;Hydrocortisone;ImProv;improved;Infant;innovation;integrated care;intergenerational;Intervention;Knowledge;late life;Length;Life;Link;Literature;Low income;lower income families;Measures;Mediating;Mediation;Medicaid;Mental Depression;Mental Health;Methylation;Minority;Minority Groups;Modeling;Morbidity - disease rate;mortality;Mothers;North Carolina;Outcome;Paternal Age;Pathway interactions;patient population;Patients;Perinatal;physical conditioning;Population;post intervention;Prevention;Primary Care;primary care provider;primary care setting;Process;programs;promote resilience;protective factors;Provider;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Resources;respiratory;response;Risk;Risk Factors;Sampling;satisfaction;Services;Sinus;social;Source;Spanish/English;Spottings;Stress;stressor;Structure;telomere;Telomere Shortening;Testing;treatment as usual;treatment group;Underserved Population;usual care arm;Violence;Well Child Visits

PROJECT_TITLE: The impact of stress and caregiver sensitivity on infant cellular aging in a population of under-resourced families: A randomized controlled trial.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Autistic adolescents have deficits in age-appropriate daily living skills (e.g., hygiene, laundry, cooking, cleaning, managing money) that impact their ability to successfully transition from high school to the adult world and achieve positive outcomes in employment, college, independent living, and quality of life. Our team iteratively developed the first evidence based DLS intervention for autistic adolescents without ID, Surviving and Thriving in the Real World (STRW), which recently demonstrated statistically significant and clinically meaningful gains in daily living skills for adolescents with autism compared to a social skills control group. The current proposal seeks to conduct a fully powered, multi-site randomized clinical trial to assess the efficacy of the STRW-telehealth (STRW-T) intervention to increase the acquisition of age-appropriate daily living skills and examine the impact of improved daily living skills on early adult outcomes after high school graduation.

PI_NAMEs: DUNCAN, AMIE MARIE (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: acceptability and feasibility;Adaptive Behaviors;Address;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Aftercare;Age;aged;attentional control;autism spectrum disorder;autistic;Behavior assessment;Behavior Therapy;Budgets;Caregivers;Caring;Chronology;Clinical;clinical practice;Clinical Treatment;clinically significant;Collaborations;college;Communities;Control Groups;cooking;COVID-19;critical developmental period;Data;Development;diaries;efficacy evaluation;Employment;Enrollment;Environment;evidence base;Family;Feasibility Studies;follow-up;Future;Goals;graduate school;high school;Home;Hygiene;Impairment;improved;Independent Living;Individual;individuals with autism spectrum disorder;innovation;Intellectual functioning disability;Intervention;Interview;Link;Measurement;Measures;Mediating;Methods;Occupations;Outcome;Participant;peer;Persons;Phase;Populations at Risk;Quality of life;Randomized;randomized, clinical trials;Research;Role;Sampling;Schools;Series;Site;skills;social skills;statistics;Surveys;survival outcome;System;Teenagers;telehealth;Telephone;tenth grade;transition to adulthood;trial comparing;twelfth grade;United States;Work;young adult;Youth

PROJECT_TITLE: A Multisite RCT of a Daily Living Skills Intervention for Autistic Adolescents Prior to the Transition to Adulthood

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MOSCOW

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE – OVERALL COMPONENT  Center of Biomedical Research Excellence (COBRE) in Nutrition and Women’s Health Inadequate or imbalanced nutrition is one of the most interwoven, unifying themes underlying poor health among women across the lifespan. This COBRE will support research leading to evidence-based practices to improve women’s health through better nutrition. This research addresses the roles of gender in health and disease; promotes participation of women in clinical nutrition research; and integrates sex as a biological variable in basic, preclinical, and translational nutrition research.

PI_NAMEs: MCGUIRE, MICHELLE KAY (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Automobile Driving;Basic Science;Biomedical Research;Body fat;Cell Nucleus;Centers of Research Excellence;Clinical Nutrition;Collaborations;Communities;Complex;Coupled;critical period;Critiques;Dedications;Development;Disease;early-career faculty;Ensure;Environment;Evaluation;evidence base;Evidence based practice;excessive weight gain;experience;Faculty;Food;food insecurity;formative assessment;frontier;Funding;Gender;gender disparity;Goals;Grant;Growth;Health;health care availability;health disparity;Health Food;health inequalities;Healthcare;High Risk Woman;Idaho;improved;Infrastructure;innovation;Institution;institutional capacity;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Investments;Knowledge;Laboratories;Lactation;Lead;life span;marginalized population;Medical;meetings;Mental Health;Mentors;Mentorship;Monitor;multidisciplinary;Nutrient;nutrition;Nutritional;Nutritional Study;Obesity;outreach;Personal Satisfaction;physically handicapped;Physicians;Physiological;Population;Poverty;pre-clinical;Pregnancy;Productivity;programs;Qualifying;recruit;reproductive;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Rural;Scientist;senescence;Services;sex as a biological variable;social;Source;Students;success;Time;timeline;Training;Translating;Underserved Population;Universities;Woman;women versus men;Women's Health;Work

PROJECT_TITLE: COBRE in Nutrition and Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Rural Health;Women's Health Research

PROJECT_TERMS: Advisory Committees;Affect;agricultural community;Annual Reports;Area;Award;Budgets;Businesses;career development;Cell Nucleus;Centers of Research Excellence;Communication;Core Facility;Critiques;Development;Ensure;Evaluation;evidence base;expectation;experience;Faculty;faculty mentor;frontier;Funding;Funding Opportunities;Geography;Goals;Grant;Health;Health Personnel;high risk;Hispanic Populations;Idaho;improved;Infrastructure;innovation;Institution;interest;International;Laboratories;Medical Education;meetings;member;Mentors;multidisciplinary;nutrition;Nutritional Study;Phase;Pilot Projects;Population;Postdoctoral Fellow;Process;Productivity;programs;Qualifying;Ramp;Recommendation;recruit;Regulation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Support;Risk;Rural;scientific organization;Scientist;Services;Technology;Underrepresented Populations;United States National Institutes of Health;Universities;Vocational Guidance;Vulnerable Populations;Woman;Women's Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Prevention;Women's Health Research

PI_NAMEs: WILLIAMS, JANET E. (contact)

PROJECT_TERMS: Address;Aging;Ally;Anatomy;Anthropometry;Basal metabolic rate;Behavior;Behavioral;Biochemical;Biochemistry;Biological;Biomedical Research;Blood Chemical Analysis;Body Composition;Body Weight decreased;Businesses;Centers of Research Excellence;Chemistry;Clinical assessments;cohort;Communities;Complement;Computers;Data Analyses;Data Collection;Data Science;Dedications;Dietary Assessment;Dietary Intervention;Dietetics;Discipline;Ensure;Equipment;Exercise;experimental study;Faculty;field study;Financial Support;Food;Genetic;Goals;Growth;Health;health assessment;human subject;Human Subject Research;Idaho;Indirect Calorimetry;innovation;Institution;instrumentation;International;Intervention Studies;Kinesiology;Laboratories;laboratory experience;Lactation;life span;Maintenance;Malnutrition;mass spectrometer;Measurement;Metabolic;Methodology;Microbiology;mid-career faculty;multidisciplinary;Nature;novel;Nutrient;nutrition;Nutrition Assessment;Nutritional;Nutritional Science;Nutritional status;Nutritional Study;operation;Outcome;Phase;Physiological;Physiology;Pilot Projects;Pregnancy;Productivity;Psychology;Research;Research Design;research facility;Research Personnel;Research Project Grants;Research Support;Resources;Running;Sampling;Science;Scientist;Services;Signs and Symptoms;social;Sociology;Specialist;stable isotope;Students;Technical Expertise;Training;Universities;Weight;Weight Gain;Women's Health

PROJECT_TITLE: Research Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: BROWN, ANN FROST (contact)

PROJECT_TERMS: Adipose tissue;Aerobic Exercise;Age;aged;American;Area;Behavior;Body Composition;Body fat;Body Image;Body mass index;Body Weight;Cardiovascular Diseases;Categories;Centers of Research Excellence;child bearing;Classification;Clinical;college;community center;comorbidity;Consumption;County;Dancing;Data;design;Diet;diet and exercise;dietary;Dietary intake;Dietary Intervention;Dyslipidemias;emerging adult;epidemiology study;evidence base;Exercise;exercise intervention;experience;Female;fitness;frontier;Future;General Population;girls;Goals;Health;health care availability;Height;High Prevalence;Hormones;Hypertension;Idaho;Image;improved;Individual;Inflammation;innovation;Intervention;Intervention Trial;Life Style;Literature;Measurement;Measures;Medical;men;Menstrual cycle;Metabolic;Metabolic syndrome;Metabolism;Methodology;Muscle;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;obese person;Obesity;obesity risk;Older Population;Outcome;Oxidative Stress;Persons;Phase;Physical activity;physical conditioning;Physical Exercise;Physical Fitness;Physiological;poor health outcome;Population;Prediabetes syndrome;Premenopause;pressure;Prevalence;Proteins;Randomized;Research;Research Design;Research Project Grants;resistance exercise;Rest;Risk;Rural;rural area;Rural Community;systemic inflammatory response;Testing;Thinness;Unhealthy Diet;United States National Institutes of Health;Universities;Visceral;Weight;Woman;Women's Health;Work;young woman

PROJECT_TITLE: Research Project - RPL Brown


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rural Health;Serious Mental Illness;Social Determinants of Health;Women's Health Research

PI_NAMEs: CHEN, YIMIN  (contact)

PROJECT_TERMS: Academy;Affect;Anxiety;Birth;Breast Feeding;Centers of Research Excellence;Cholecalciferol;Classification;Clinical;clinical care;cognitive development;Complex;Consumption;Corn Oil;critical period;Cutaneous;Data;Dietary Assessment;Dietary intake;Dietary Intervention;Double-Blind Method;Emotional;experience;frontier;Future;Geographic Locations;Goals;Growth;Health;health care availability;Health Food;health of the mother;high risk population;Hormones;Human Milk;Hydrocortisone;Idaho;Immunoglobulins;immunoregulation;improved;Infant;Infant Care;Infant Health;infant outcome;innovation;Intervention;Intervention Studies;Intervention Trial;Knowledge;Lactation;Link;maternal depression;Maternal Health;maternal stress;maternal weight;Measures;Medicine;Mental Depression;Mental Health;Metabolic Diseases;Milk;Minerals;motherhood;Mothers;Motor;Neonatal;Neonatal Mortality;neonatal sepsis;Nutrient;nutrition;Outcome;Oxytocin;Physiological;Placebo Control;Placebos;Population;Postpartum Depression;Postpartum Period;Predisposing Factor;Premature Birth;Premature Infant;prenatal;prevent;prospective;Protein Analysis;Proteins;Proteomics;Psyche structure;Public Health;Questionnaires;Randomized;randomized placebo controlled trial;Research;Research Project Grants;response;Risk;Risk Factors;Rural;rural area;Salivary;self-compassion;Serum;skin color;Sleep disturbances;Stress;stress reduction;stressor;Sun Exposure;Sunlight;Supplementation;Testing;Time;United States National Institutes of Health;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamins;Vulnerable Populations;Weight Gain;Woman;Women's Health

PROJECT_TITLE: Research Project - RPL Chen


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: LANE, GINNY  (contact)

PROJECT_TERMS: Address;Adult;American;Area;Behavior;Blood;Body Weight decreased;care giving burden;caregiving;Categories;Cause of Death;Centers of Research Excellence;Characteristics;Chronic;Classification;Complex;Complications of Diabetes Mellitus;Consumption;Data;data integration;Death Rate;Development;diabetes control;Diabetes Mellitus;diabetes prevention program;diabetes risk;diabetic;Diet;Dietary intake;Dietary Practices;disability;Discrimination;Disease;Disease Progression;disorder risk;Disparity;Emotional;emotional factor;ethnic minority;Ethnic Origin;Event;experience;Experimental Designs;Exposure to;Fasting;Food;food security;frontier;Gases;Gender;Gender Role;Genetic Variation;Glycosylated hemoglobin A;Goals;Health;health care availability;health care service;health care service utilization;Health Food;Health Promotion;Healthcare;high risk;Hispanic;Hispanic Populations;Hispanic Women;Idaho;Immigration;improved;innovation;Intervention;Interview;Laboratories;Laws;Life;Life Style;lifestyle factors;Location;male;Measures;Memory;men;Mental Health;Methods;Micronutrients;Modeling;mortality risk;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;Nutritional;Obesity;Overweight;Pacific Northwest;Patriarchies;Pharmaceutical Preparations;Physical activity;Policies;poor health outcome;Population;Populations at Risk;Prevalence;prevent;programs;Psyche structure;Race;racial minority;Research;Research Project Grants;Resources;Risk;Rural;Self Care;Services;Sex Orientation;social;Socioeconomic Status;Spottings;Stress;Structure;Surveys;System;Testing;Time;Trauma;trend;Underrepresented Populations;United States;United States National Institutes of Health;Variant;Vulnerable Populations;White Women;Woman;Women's Health;Women's study

PROJECT_TITLE: Research Project - RPL Lane


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Women's Health Research

PROJECT_TERMS: Address;Air;Ally;Americans with Disabilities Act;Anatomy;Anthropometry;Architecture;Area;Basal metabolic rate;Behavior;Behavioral;Biochemical;Biochemistry;Biological;Blood;Body Composition;Centers of Research Excellence;Chemistry;Clinical assessments;Complement;Data Analyses;Data Collection;Data Science;Dietary Assessment;Dietary Intervention;Dietetics;Disabled Persons;Discipline;Dryness;Engineering;Equipment;experimental study;Faculty;Floor;Food;Future;Genetic;Goals;Grant;Health;health assessment;Heating;Height;Hour;human subject;Idaho;improved;innovation;instrumentation;Intervention Studies;Kinesiology;Laboratories;Light;Location;Malnutrition;mass spectrometer;Measurement;Metabolic;Microbiology;multidisciplinary;Nature;novel;Nutrient;nutrition;Nutritional;Nutritional Science;Nutritional status;Nutritional Study;Outcome;Physiological;Physiology;Pilot Projects;Privacy;Productivity;Psychology;repaired;Research;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Running;Sampling;Science;Scientist;Services;social;Sociology;Spectrum Analysis;square foot;Steam;Students;Surface;Symptoms;System;Technology;Universities;Urine;usability;ventilation;Water;Weight;Women's Health

PROJECT_TITLE: Alteration and Renovation


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Otitis Media;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Otitis alternative disease. research by to are media or inflammation of the middle ear is a significant cause of morbidity in t he US and worldwide, and prevention, diagnostic and treatment strategies are urgently needed to alleviate the burden of this Strengthening the collaborative network among otitis media investigators will l ead to cross-disciplinary and training of the next generation of researchers, with a strong representation of different backgrounds gender, ethnicity, specialty, technical skills, and leadership experiences. Our program of activities is designed support and advance careers in otitis media research, particularly for early-stage investigators and those who from under-represented minority groups.

PI_NAMEs: PRECIADO, DIEGO ;RYAN, ALLEN F.;SANTOS-CORTEZ, REGIE LYN PASTOR (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 5 year old;Admission activity;Antibiotics;Award;Awareness;burden of illness;career;Career Mobility;Child;childhood hearing loss;Clinical;Cognition;cohort;Collaborations;collaborative environment;Communication;Communities;cultural competence;Data;demographics;design;Development;diagnostic strategy;Discipline;Disease;Diverse Workforce;doctoral student;Early Diagnosis;Early treatment;Educational Curriculum;Educational workshop;Epidemiology;Equity;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;Faculty Recruitment;Feedback;Feeling;Female;Focus Groups;Fostering;Functional disorder;Funding;Gender;Global Awareness;Goals;graduate student;Grant;Grant Review;Health;hearing impairment;Home;implicit bias;improved;Incidence;Individual;Inflammation;Information Dissemination;innovation;Institution;instrument;interest;International;Interview;Journals;Knowledge;Language;Leadership;leadership development;Learning;lecturer;lectures;medical specialties;meetings;Mentors;middle ear;Minority Groups;Minority Status;Monitor;Morbidity - disease rate;multidisciplinary;National Institute on Deafness and Other Communication Disorders;next generation;Operative Surgical Procedures;Otitis;Otitis Media;Otolaryngology;Outcome;Participant;participant retention;Pathogenesis;Patient Recruitments;peer coaching;Peer Review;Persons;Pneumococcal vaccine;Policies;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Prevalence;Prevention;Prevention strategy;Professional Organizations;program dissemination;programs;Progress Reports;Protocols documentation;Publications;Qualifying;Recommendation;recruit;Research;Research Personnel;responsible research conduct;Schedule;Scholarship;Science;skills;social;social culture;Social Sciences;Societies;Speech;Streptococcus pneumoniae;Structure;success;Technical Expertise;Testing;theories;Time;Training;Training Activity;Training Programs;Transcript;Travel;treatment strategy;undergraduate student;Underrepresented Minority;United States National Institutes of Health;web site;webinar

PROJECT_TITLE: Development of a diverse workforce through mentoring networks among otitis media researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-X (66)]


ORG_CITY: SAN JUAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: The goal of the G-RISE Program at the University of Puerto Rico Rio Piedras campus is to support educational and research activities that will enhance the diversity and quality of the biomedical and research workforce at UPR-RP by means of supporting capacity building activities with a primary focus on achieving a continuous research experience as well as workshops and seminars designed to improve the students’ professional skills. We are expecting to deliver the next generation of a well-qualified biomedical workforce.

PI_NAMEs: CARBALLEIRA, NESTOR MANUEL (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Puerto Rico;Universities

PROJECT_TITLE: G-RISE at the University of Puerto Rico Rio Piedras

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Headaches;Migraine;Natural Products;Neurosciences;Nutrition;Pain Research;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Migraine, a chronic intermittent headache disorder, ranks in the top five causes for years lived with disability. Some basic science research and one study in humans suggest that cocoa extract supplements may be effective for migraine prevention. The goal of this application is to perform a pilot study of a cocoa extract supplement for episodic migraine to help inform the design of a future, full-scale efficacy trial.

PI_NAMEs: RIST, PAMELA M. (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Address;Adherence;Adult;Adverse event;Age;alternative treatment;Animals;arm;Basic Science;Cacao Plant;Caffeine;Calcitonin Gene-Related Peptide;Calcium Channel;cancer prevention;Cardiovascular Diseases;Cell Culture Techniques;Chocolate;Chronic;Clinical Trials;Cocoa Powder;Collection;Confidence Intervals;Consumption;craving;Data;Data Collection;data management;data quality;design;Diet;dietary supplements;disability burden;Dose;Double-Blind Method;double-blind placebo controlled trial;Effectiveness;effectiveness evaluation;efficacy trial;Enrollment;epicatechin;evidence base;experience;Flavanol;food craving;Foundations;Frequencies;Functional disorder;Future;Goals;Guidelines;hazard;Headache;Headache Disorders;Human;Individual;Inflammatory Response;Infrastructure;Intervention;Knowledge;men;Migraine;migraine treatment;Modality;Multivitamin;National Center for Complementary and Integrative Health;Natural Products;Neurons;older adult;Outcome Study;Pain management;Participant;patient population;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;Placebos;Population;Preparation;Prevalence;prevent;Prevention;Procedures;Protocols documentation;Randomized;Rattus;real time monitoring;Recommendation;recruit;Reporting;Repression;Research;Research Priority;response;Risk;Role;Sampling;Severities;side effect;Structure of trigeminal ganglion;Supplementation;Testing;Theobromine;Urine;Woman;years lived with disability

PROJECT_TITLE: Cocoa Flavanols for Migraine: A Pilot Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SH (11)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative . It is well appreciated that vascular complications associated with lifestyle-related diseases, such as diabetes, contribute to an increased risk of hypertension, coronary artery disease, and heart failure associated with preserved ejection fraction (HFpEF). Yet, mechanisms, especially those underlying vascular smooth muscle dysfunction, are poorly understood. This proposal addresses these fundamental knowledge gaps and fulfills relevant public health goals and NIH missions by generating fundamental basic knowledge that could help identify and develop novel treatment strategies to address vascular complications associated with diabetes and HFpEF.

PI_NAMEs: NAVEDO, MANUEL F (contact);NIEVES-CINTRON, MADELINE

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: A kinase anchoring protein;Address;Adenosine Triphosphate;Animal Model;Animals;arteriole;base;Biochemistry;Biosensor;Blood flow;Blood Glucose;Blood Pressure;Blood Vessels;Cells;Complex;Coronary Arteriosclerosis;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Diabetes Mellitus;diabetic;Diameter;Disease;EFRAC;Electrophysiology (science);experimental study;extracellular;Extracellular Space;Functional disorder;Glucose;Goals;health goals;Heart failure;Hyperglycemia;Hypertension;Imaging Device;Imaging Techniques;Impairment;in vivo;innovation;insight;Ion Channel;Knowledge;Life Style;Link;live cell imaging;Measurement;Mediating;member;Metabolic;Mission;Modeling;Molecular;Muscle Contraction;Muscle function;Myography;nanocomplexes;Nanoscopy;novel;Nucleotides;particle;patch clamp;Pathologic;Pathway interactions;Physiological;Physiology;preservation;pressure;Process;Property;Proteins;Public Health;response;Risk;Role;Scaffolding Protein;Signal Transduction;spatiotemporal;Testing;therapeutic target;treatment strategy;United States National Institutes of Health;Vascular Smooth Muscle;vasoconstriction;Vasomotor;Work

PROJECT_TITLE: Mechanisms of VSM dysfunction in diabetes and HFpEF

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed IMSD program at Dartmouth College will strengthen current doctoral training in biomedical sciences through enhanced scientific, personal, professional, and leadership development. Trainees will be supported by multi-tiered team mentorship and cohort building to create a thriving, intellectual community for PhD students from historically underrepresented groups. Pre-matriculation and ongoing programming throughout doctoral training will support trainees to become leaders in the biomedical research workforce.

PI_NAMEs: BEZANILLA, MAGDALENA ;BOOKER, ANSLEY A;GILBERT-DIAMOND, DIANE IHN AE (contact)

PROJECT_TERMS: college

PROJECT_TITLE: IMSD at Dartmouth College


ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: PROJECT NARRATIVE Despite the many improvements in health and the increase in life expectancy over the last 50 years, there persist significant health disparities among Alaska Native (AN) people including the highest incidence of colon cancer reported globally; the highest incidence of gastric cancer in the U.S.; persistently high rates of tobacco use; the highest regional rates of RSV in observed in the U.S.; high rates of early childhood dental caries; rural communities without piped water and sanitation; high rates of suicide; high rates of unintentional injury; and high rates of chronic liver disease and related mortality, all of which need to be addressed. However, it is also essential to acknowledge that the Alaska Native people possess tremendous strengths; despite the negative impact of colonization, boarding schools, and other adverse social determinants of health, the sense of community, respect for elders, and the traditions and cultures of the many Alaska Native Tribes are strong. The Alaska Native Center for Health Research will address these disparities while incorporating Alaska Native peoples’ world views and focusing on resilience and positive elements across and within Alaska Native communities.

PI_NAMEs: THOMAS, TIMOTHY K (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Accidental Injury;Address;Alaska;Alaska Native;Alaska Native population;American Indian Population;Biometry;career;Caring;Centers of Research Excellence;chronic liver disease;Collaborations;Colon Carcinoma;Communities;community engaged research;community engagement;Community Health;community research;Consultations;Data;data management;Dedications;Dental caries;Disparity;early childhood;Elderly;Elements;empowerment;Ensure;Epidemiology;Funding;Goals;Grant;Health;Health care facility;Health Disparities Research;health disparity;health organization;Health Services;Health system;hospital care;Hospitals;improved;Incidence;Indigenous;Information Technology;innovation;Institution;Life Expectancy;malignant stomach neoplasm;Medical center;medical specialties;member;Mentorship;Mission;mortality;Native American Research Center for Health;Persons;programs;Qualitative Research;Recording of previous events;recruit;Recruitment Activity;Reduce health disparities;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;resilience;respiratory;Rural Community;Sanitation;Schools;Secure;Services;Sexually Transmitted Diseases;skills;social health determinants;Students;suicide mortality;suicide rate;tertiary care;Tobacco use;Training;Training and Education;tribal health;Tribally Based Participatory Research;Tribes;United States;United States National Institutes of Health;Vision;Water;Writing

PROJECT_TITLE: Alaska Native Center for Health Research (ANCHR)


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: FERUCCI, ELIZABETH D (contact)

PROJECT_TERMS: Address;Advisory Committees;Alaska;Alaska Native;Alaska Native population;career;Childhood;Clinical;Clinical Research;Clinical Trials Network;Communities;Community Health Services;design;Development;Ensure;Evaluation;Goals;Grant;Health;Health Disparities Research;health disparity;health organization;improved;Individual;innovation;interest;Knowledge;Lead;Mentors;Monitor;Native American Research Center for Health;Personal Satisfaction;Persons;Phase;population health;Positioning Attribute;programs;Recording of previous events;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Services;skills;success;timeline;Training;translational research program;tribal health;Vision

PROJECT_TITLE: ANCHR Admin Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: KECK, JAMES W. (contact)

PROJECT_TERMS: Address;Advocate;Alaska;Alaska Native;Alaska Native population;Area;Bioethics;Biomedical Research;Biometry;Collaborations;Communities;community based participatory research;community engaged research;community engagement;data acquisition;Data Analyses;Data Collection;data management;empowerment;Ethics;Ethics Consultation;Goals;Health;health disparity;health organization;Health Services Research;Indigenous;Individual;Institution;Knowledge;Mission;Patient Recruitments;Personal Satisfaction;Phase;Process;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resources;Services;Structure;Training;Training Programs;tribal community;tribal health;Tribes;Work

PROJECT_TITLE: ANCHR Research Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: JOHNSTON, JANET MARIE (contact)

PROJECT_TERMS: adverse outcome;Affect;Alaska;Alaska Native;Alaska Native population;American Indian Population;Anti-viral Agents;burden of illness;care seeking;Cause of Death;Characteristics;Chronic Disease;chronic liver disease;Cirrhosis;Clinical;clinically significant;cohort;Cohort Studies;Data;Death Rate;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;Disease Progression;disease registry;elastography;Enrollment;Environment;Epidemiologist;experience;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibrosis;Goals;HCV Liver Disease;Health;health disparity;Hepatitis;Hepatitis B;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;improved;Individual;Infection;innovation;Investigation;Lead;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Longitudinal, observational study;Malignant neoplasm of liver;Measurement;Measures;Medical center;Metabolic syndrome;Monitor;non-alcoholic fatty liver disease;non-Native;nonalcoholic steatohepatitis;Obesity;Oral;Outcome;Participant;Patient Recruitments;Patient Self-Report;permissiveness;Persons;Pharmaceutical Preparations;Population;Prevalence;prevent;Primary carcinoma of the liver cells;programs;Publishing;racial population;rate of change;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Risk Marker;Secondary Prevention;Symptoms;Time;Time Study;tribal health;vibration;Viral;Work

PROJECT_TITLE: An investigation into how hepatitis C status affects fibrosis stage and progression among Alaska Native people with non-alcoholic fatty liver disease


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MEYER, JENNIFER A (contact)

PROJECT_TERMS: Age;age group;age related;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Belief;Centers for Disease Control and Prevention (U.S.);Characteristics;Charge;Clinical Management;Code;Communication Tools;Communities;Community Health;Community Health Aides;Community of Practice;Computer software;cost;cost effective;critical developmental period;Cross-Sectional Studies;Data;Data Sources;Databases;Decision Making;demographics;Dental;Dental caries;Dental Records;Development;Discipline;economic impact;Economics;Electronic Health Record;Electronics;Enabling Factors;Ensure;epidemiology study;Evaluation;evidence base;evidence based guidelines;Exposure to;Fluorides;Goals;Government Agencies;Health;health disparity;health equity;health organization;Health Personnel;Health Professional;Health Promotion;Health Services;Health system;improved;Income;innovation;Institution;Intervention;intervention program;Investigation;Knowledge;Leadership;Measures;meetings;Methods;Modernization;Monitor;Oral health;Outcome;Pattern;Policies;Policy Maker;Policy Making;Politics;Population;population health;Predisposing Factor;Prevalence;Prevention;Procedures;Process;programs;Provider;Public Health;Public Health Practice;Public Policy;Race;Recommendation;Records;Reinforcing Factor;Research;Research Project Grants;Resources;Respondent;Retrospective Studies;Role;screening;secondary outcome;Secondary to;social;social media;Supplementation;surveillance strategy;Surveys;systematic review;Technology;Time;tool;Tooth Diseases;Tooth structure;Training;trend;tribal health;United States;United States Indian Health Service;Vulnerable Populations;Water;Water fluoridation;Work

PROJECT_TITLE: A public health practice investigation exploring the impact of community water fluoridation among American Indian and Alaska Native populations in Alaska.


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Racial and Ethnic Minority Health Research;Rural Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: DOBSON, JENNIFER DAWN (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Air;air filtration;air monitoring;Air Pollutants;Alaska Native;American Indian Population;American Indians;arctic climate;Aromatic Polycyclic Hydrocarbons;base;Chemical Exposure;Chemicals;chronic respiratory disease;Clinic;Coughing;Crowding;Development;Effectiveness;effectiveness evaluation;Elements;Enrollment;evidence base;Exclusion;experience;Exposure to;fine particles;Goals;Health;Heating;high efficiency particulate air filter;Home;Household;Housing;Human;improved;Indoor Air Quality;indoor particulate matter;Knowledge;Lung Diseases;Measures;Monitor;monitoring device;Native-Born;new technology;Nose;Outcome;Participant;Particulate;Particulate Matter;Patient Self-Report;Performance;personal exposure monitor;pollutant;Population;portability;Pulmonology;recruit;Reduce health disparities;Reporting;Research;Research Project Grants;Resources;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;Risk Factors;rural Alaska;rural dwellers;Smoke;Smoker;Surveys;Symptoms;Testing;Time;Tobacco;tribal organization;ventilation;volatile organic compound;wearable device;Wheezing;Wood stove

PROJECT_TITLE: The effect of high efficiency particulate air (HEPA) filters on high particulate rural Alaska Native homes


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Dysregulation of molecular clock function in the placenta is a novel mechanism causing poor pregnancy outcomes, leading to lifelong health consequences for the newborn. This transdisciplinary project proposes a new, high impact virtual consortium that will advance fundamental knowledge into chemically-induced dysregulation of the molecular clock in the placenta. This work will transform our understanding of pregnancy disorders stemming from environmental exposures and set the basis for targeting preventive approaches related to the molecular clock.

PI_NAMEs: VEIGA-LOPEZ, ALMUDENA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: adverse pregnancy outcome;Atrazine;Binding;Birth;Cell fusion;Cell Line;Cell model;cell motility;Cell Physiology;Cells;Chemical Exposure;Chemicals;Childhood;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;cytotrophoblast;Data;Data Set;Development;Disease;environmental chemical;Environmental Exposure;environmental stressor;Epidemiologist;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Exposure to;Farm;farm worker;fetal;Fetal Development;Fetus;Functional disorder;Gene Expression;Genes;Genetic Transcription;Gestational Age;Goals;Growth;Growth Factor Receptors;Health;Human;Hypertension;hypertensive;improved;infant morbidity/mortality;Infant Mortality;insight;Intervention;Invaded;Knock-out;Knowledge;Lead;Life;Light;Link;Luciferases;Maps;maternal morbidity;Maternal Mortality;Mediating;Molecular;molecular clock;morphometry;Mothers;mouse model;Mus;Newborn Infant;novel;novel strategies;offspring;Organophosphates;Outcome;Pathway interactions;Peripheral;pesticide exposure;Pesticides;Physiological Processes;Placenta;placental trophoblasts;Play;Poison;Polychlorinated Biphenyls;Population;Post-Transcriptional Regulation;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Outcome;pregnant;Premature Birth;Preventive;programs;Proliferating;Protein Family;Publishing;pyrethroid;Reporter;reproductive outcome;Risk;Role;sex;Signal Transduction;Small for Gestational Age Infant;stem;Syncytiotrophoblast;Testing;Tissues;Toxic effect;Toxicant exposure;Toxicology;transcriptome sequencing;transcriptomics;trophoblast;Variant;Villous;virtual;Work;Working Women

PROJECT_TITLE: Chemical exposure disruption of the placental circadian clock

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (VC)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Patient Safety;Prevention;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The current SARS-CoV-2 vaccines require frequent boosting due to limited potency, durability, and breadth of neutralizing antibody responses and limited development of antigen-specific T cell responses. In the proposed clinical trial, we will test a novel immunotargeting vaccine approach to improve both B- and T- cell responses against SARS-CoV-2. Our strategy that has broad applicability for the development of vaccines for the prevention of infection and disease. More effective vaccine technology would have tremendous long term public health impact, with both individual and population-level benefits, including requiring less frequent or fewer vaccine doses, decreasing infection-related complications and transmission, and decreasing the economic and health systems burdens of pandemic infections.

PI_NAMEs: CHEW, KARA W (contact);DEEKS, STEVEN GRANT;HARTIGAN-O'CONNOR, DENNIS J.

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Acceleration;adaptive immune response;Address;Adenoviruses;Adjuvant;Adverse event;Antibodies;Antibody Response;Antibody titer measurement;antigen-specific T cells;Antigens;B Cell Proliferation;B-Cell Development;B-Lymphocytes;Blood;booster vaccine;CD3 Antigens;Characteristics;Chimeric Proteins;Clinical Trials;COVID-19;COVID-19 vaccine;Democracy;design;Development;Disease;Dose;draining lymph node;Economics;Event;Failure;FDA approved;Future;genetic vaccine;Grant;Health system;Helper-Inducer T-Lymphocyte;Human;Immune response;Immunization;immunogenicity;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Fragments;Immunology;improved;Individual;Infection;Infection prevention;Inflammatory;Influenza;interest;Knowledge;Link;Macaca;Monoclonal Antibody HuM291;Mucous Membrane;neutralizing antibody;nonhuman primate;novel;novel strategies;novel vaccines;Older Population;pandemic disease;Participant;pathogen;Pathway interactions;peripheral blood;Phase;Plasma Cells;Population;post SARS-CoV-2 infection;prevent;Public Health;Randomized;Reaction;receptor binding;recruit;resilience;response;RNA vaccination;RNA vaccine;Role;Safety;safety testing;Saliva;Sampling;SARS-CoV-2 spike protein;SARS-CoV-2 variant;secondary endpoint;Secondary Immunization;Series;Serious Adverse Event;Serum;Site;Special Event;Specificity;Structure of germinal center of lymph node;success;System;T cell response;T-Lymphocyte;Technology;Testing;thrombotic;tool;transmission process;Vaccine Adjuvant;vaccine development;vaccine failure;vaccine response;vaccine strategy;Vaccines;vaccinology;vector;Virus

PROJECT_TITLE: A Phase 1/2a, randomized study of a Tfh-targeting genetic vaccine adjuvant designed to induce broad, durable immune responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-M (S1)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: OMAHA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: PROJECT NARRATIVE – OVERALL We propose establishing the Center for Cardiovascular Research in Biomechanics (CRiB), which will support research aimed at the development of novel biomedical materials and devices to treat cardiovascular diseases. Our CRiB Center encompasses a robust mentoring program for junior investigators, a unique Tissue Analysis Core, and three research projects focused on the effects of sex on vascular elastogenesis and the development of novel materials and devices for Peripheral Artery Disease surgical treatment and post-treatment recovery using elastomeric bypass grafts and ischemic wound dressings.

PI_NAMEs: KAMENSKIY, ALEXEY  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Aftercare;Animal Model;Animals;Area;Arteries;Biological;Biomechanics;Biomedical Research;Blood Vessels;Bypass;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Carotid Arteries;Cause of Death;Centers of Research Excellence;Characteristics;Clinical;clinical translation;Collaborations;Coronary artery;Databases;Dedications;Development;Device or Instrument Development;Devices;disability;elastomeric;Elastomers;Ensure;Environment;Evaluation;experience;Extramural Activities;Fostering;Foundations;Funding;Goals;Health Benefit;Human;Human Characteristics;human data;human subject;human tissue;Impairment;improved;Industry;Infrastructure;innovative technologies;Interdisciplinary Study;interest;Intervention;Ischemia;Lead;Lower Extremity;man;Mechanics;Mentors;Methods;Molecular;Morbidity - disease rate;mortality;novel;Operative Surgical Procedures;Outcome;Patients;Peripheral arterial disease;pharmacologic;pre-clinical;Productivity;professor;programs;Quality of life;Race;Recovery;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Scientist;Seasons;sex;Societies;Solid;Stents;success;Talents;Technology;tenure track;Testing;Tissues;Training;Translational Research;Translations;Treatment Failure;treatment response;United States National Institutes of Health;Universities;Vascular Diseases;Vision;wound dressing


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular

PROJECT_TERMS: Advisory Committees;Animal Model;base;Biomechanics;Budgets;Cardiovascular Diseases;Cardiovascular system;career;career development;Centers of Research Excellence;clinical translation;Collaborations;Community Developments;Complement;Coupled;Development;Device or Instrument Development;Devices;Educational workshop;Elements;Ensure;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Feedback;Funding;Goals;graduate student;Grant;Grant Review;Growth;Human Resources;human tissue;Industry;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Journals;Leadership;meetings;member;Mentors;multidisciplinary;Nebraska;operation;outreach;Performance;Pilot Projects;pre-clinical;Privatization;Professional Organizations;Program Research Project Grants;programs;recruit;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Scholarship;scientific organization;Scientist;Series;Solid;Strategic Planning;symposium;synergism;Teacher Professional Development;tenure track;Time;Tissues;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Transplantation

PI_NAMEs: DESYATOVA, ANASTASIA S (contact)

PROJECT_TERMS: Age;Animal Model;Animals;Architecture;Arteries;Awareness;base;Behavior;Biologic Characteristic;Biological;biomechanical test;Biomechanics;Blood Vessels;Businesses;calcification;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Characteristics;Collaborations;Communities;Contracts;Credentialing;Data;data sharing;Databases;Demographic Factors;design;Development;Device or Instrument Development;Devices;Direct Costs;Disease;Educational workshop;Ensure;Evaluation;experience;extracellular;Extramural Activities;Facilities and Administrative Costs;Fee-for-Service Plans;Feedback;Fees;Fiber;Functional disorder;Funding;Gases;Geometry;Goals;Histologic;Human;human tissue;improved;Industry;man;manufacture;Measures;Mechanics;Medical center;member;Modeling;Myocardium;Nebraska;Organ Procurements;Performance;Permeability;Physiological;Physiology;pre-clinical;Procedures;Protocols documentation;Publications;Race;Recovery;repaired;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Sampling;Scanning Electron Microscopy;Scientist;Services;sex;Skin;soft tissue;Specialist;Specimen;Standardization;Stress;Structure;Students;Suggestion;Techniques;Testing;Tissue Donors;Tissue Model;Tissue Procurements;Tissues;Torsion;Training Activity;Tubular formation;ultrasound;United States;vapor;Vascular Graft;Veins

PROJECT_TITLE: Tissue Analysis Core (TAC)


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Women's Health Research

PI_NAMEs: JADIDI, MAJID  (contact)

PROJECT_TERMS: Adolescence;Adult;Age;Animal Model;arterial stiffness;Arteries;Atherosclerosis;biobank;Biocompatible Coated Materials;Biomechanics;Blood Vessels;calcification;Cardiomyopathies;Cardiovascular system;Characteristics;chemical stability;Coronary artery;coronary perfusion;Data;Development;Devices;Disease;Distal;Elastic Fiber;Elasticity;Elastin;energy efficiency;Ensure;Ethnic Origin;Event;Extracellular Matrix;FBN1;Female;fetal;Fiber;fibulin 1;Gelatinase A;Half-Life;health disparity;Healthcare;Heart;Histologic;Human;Human body;Human Resources;human tissue;Hypertension;Inflammation;Kidney Diseases;Left ventricular structure;Length;life span;Ligaments;Location;Locomotion;longitudinal analysis;Lung;Machine Learning;machine learning algorithm;Mass Spectrum Analysis;Mechanical Stress;Mechanics;men;Methods;Modeling;Modification;Molecular;mouse model;Movement;multiphoton microscopy;Natural regeneration;neonatal period;novel therapeutics;Organ;Organism;Outcome;Pathology;Periodic acid Schiff stain method;Periodicity;Peripheral arterial disease;Pregnancy;Process;Production;Reaction;Research;Respiration;Rest;Risk Factors;Rodent;Scanning;sex;Skin;Slide;Specimen;Stains;Statistical Models;Structure;Tendon structure;Testing;Thinness;Tissue Donors;Tissues;Tropoelastin;Vagina;Vascular Diseases;Vascular regeneration;Woman;women versus men

PROJECT_TITLE: Effects of Sex on the Elastogenesis of Vascular Elastic Fibers