NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: CLARK, DUNCAN B. (contact);LUNA, BEATRIZ

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 12/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U PITTSBURGH


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN DIEGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RAFT PHARMACEUTICALS, LLC

ORG_STATE: CA

PHR: PROJECT NARRATIVE Asthma remains a significant health problem, particularly in patients with the uncontrolled severe form of diseases and frequent exacerbations due to viral infection. Raft Pharmaceuticals will test the efficacy, exposure and preliminary safety of its new candidate RFT1124, representing a novel class of inhaled biologics targeting lung inflammation.

PI_NAMEs: BROIDE, DAVID H;KENNEDY, JOSHUA ;KOGAN, YAKOV  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Acute Lung Injury;Adaptive Immune System;Adrenal Cortex Hormones;Affect;Agonist;airway hyperresponsiveness;Amino Acid Sequence;Anti-Inflammatory Agents;Apolipoprotein A-I;Asthma;asthma exacerbation;asthma model;asthmatic;Autopsy;B-Lymphocytes;Binding Proteins;Biological;Biological Assay;Biological Products;Blood Vessels;bronchial epithelium;Bronchoconstriction;Bronchodilator Agents;C-terminal;Cell membrane;Cell Physiology;Cells;Cholesterol;Clinical Trials;Complex;Cyclic GMP;cytokine;Development;dimer;Disease;Dose;drug development;efficacy evaluation;efficacy study;efficacy testing;Eosinophilia;Epithelial Cells;Epithelium;Excision;experimental study;Formulation;Grant;Health;Human;Immune;improved;Infection;Inflammation;Inflammatory;Inhalation;Innate Immune System;Interleukin-13;Interleukin-4;Ion Channel;Laboratories;Life;Ligand Binding;Lung;Macrophage;manufacture;mast cell;meetings;Membrane Microdomains;Methods;Microbe;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;neuroinflammation;neutrophil;Neutrophilia;novel;novel therapeutic intervention;novel therapeutics;Organ;Pathologic;Pathway interactions;patient subsets;Patients;persistent symptom;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 2 study;Physiological;pre-clinical assessment;pre-Investigational New Drug meeting;Preventive therapy;Preventive treatment;Process;Proteins;Protocols documentation;pulmonary function;Pulmonary Inflammation;Pyroglyphidae;Quality of life;Rattus;receptor;Reporting;response;Rhinovirus;Rhinovirus infection;Safety;safety assessment;safety study;Signal Transduction;Slice;standard of care;Steroid Resistance;Structure of parenchyma of lung;T-Lymphocyte;targeted treatment;Testing;Therapeutic Agents;therapy development;TLR4 gene;Toxicology;Transcriptional Regulation;transcriptome sequencing;Variant;Viral;Virus Diseases

PROJECT_TITLE: Targeting lipid rafts for treatment of asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed study (PETAL: Promoting Early intervention Timing and Attention to Language) aims to determine the timing of intervention among infants with Increased Likelihood for Autism (ILA; at risk for autism by virtue of having an older sibling with autism) on communication and language outcomes at 24 months. Results of this study will determine when (9 vs 12 vs 15 months), and based on which measures (brain, language, or their combination) to augment parental support with a specialized parent-mediated coaching intervention for optimal outcomes on communication and language at 24 months.

PI_NAMEs: KASARI, CONNIE L. (contact);TAGER-FLUSBERG, HELEN

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Age;Age Months;Area;Attention;autism spectrum disorder;autistic children;Behavior;behavior measurement;behavior prediction;Behavior Therapy;Behavioral;Boston;Brain;brain based;Child;clinical practice;Communication;communication behavior;Development;Diagnosis;Early identification;Early Intervention;Electroencephalography;Enrollment;Environment;experience;Family;Family history of;Frequencies;Future;Gestures;Goals;Home;Individual;Infant;Infrastructure;Intervention;Joints;Language;Language Delays;Language Development;Language Disorders;language outcome;Learning;Life;Los Angeles;marginalization;Measures;Mediating;Mediation;Minority;Monitor;neural;Neurobiology;Nursery Schools;Outcome;Parents;Phase;Play;Population;primary outcome;Productivity;Quality of life;Questionnaires;Randomized;recruit;Resources;Rest;Risk;Sampling;Science;screening;secondary outcome;Sequential Multiple Assignment Randomized Trial;Siblings;Site;social communication;social engagement;socioeconomics;Speech;Structure;Testing;Time;Toddler;trial design;vocalization;Vocation

PROJECT_TITLE: PETAL: Promoting Early Intervention Timing and Attention to Language

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Precision Medicine

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE AXL and STAT3 signaling coordinate and exert a paracrine effect on malignant and non-malignant cells in the lung tumor microenvironment, nurturing a metastatic niche. The proposal will address an important question regarding combination of AXL inhibitors and JAK inhibitors (for STAT3 signaling blockade) as a promising targeting strategy in lung cancer patients and will provide a treatment stratification model based on intercellular crosstalk between AXL and STAT3 signaling to a potential extended clinical trial.

PI_NAMEs: TAVERNA, JOSEPHINE A (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: A549;Aftercare;Binding;Biological;Biological Assay;Biopsy;Cancer cell line;Cancer Patient;cancer therapy;CD34 gene;Cell Line;cell type;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Combined Modality Therapy;Communication;Communities;Comparison arm;Complex;Correlative Study;cytokine;Data;Dependence;design;Distant Metastasis;Dose;Drug Targeting;drug testing;Ecosystem;effective therapy;Enzyme-Linked Immunosorbent Assay;epithelial to mesenchymal transition;Epithelium;experimental study;Fibroblasts;Growth;Heterogeneity;human subject;humanized mouse;Hybrids;IL6ST gene;Immunofluorescence Immunologic;Immunologics;Implant;improved;In Vitro;in vivo;indexing;inhibitor;innovation;insight;Interleukin-11;Investigation;JAK1 gene;knock-down;Knock-out;liquid biopsy;Lung;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;lymph nodes;Macrophage;Malignant - descriptor;Malignant neoplasm of lung;Maximum Tolerated Dose;Mediating;Mesenchymal;mimicry;Modeling;molecular marker;Molecular Profiling;monocyte;mouse model;Mus;Neoplasm Circulating Cells;neoplastic cell;Non-Malignant;novel;Oncoproteins;Organoids;paracrine;Paracrine Communication;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;Phase;phase 2 study;Phase Ib Trial;Phenotype;Population;precision medicine;preclinical study;Prediction of Response to Therapy;predictive marker;prevent;Production;programs;Progression-Free Survivals;prospective;Receptor Protein-Tyrosine Kinases;recruit;Resistance;response;restraint;Safety;secondary endpoint;Signal Transduction;small hairpin RNA;STAT3 gene;stemness;Stimulus;survival outcome;System;targeted treatment;Therapeutic;Toxic effect;Translating;Transplantation;treatment strategy;treatment stratification;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor xenograft;tumorigenic;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Toward Clinical Trial: AXL-STAT3 Targeting of Lung Tumor Microenvironments

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: LAWRENCE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE Parents and caregivers of children with autism spectrum disorder (ASD) have reported that repetitive behaviors (e.g., lining up cars) and unusual interests (e.g., child’s fascination with ceiling fans) are among the most challenging aspects of their child’s behavior they have to deal with on a day-to-day basis. Existing early behavioral interventions for children with ASD have been found to be helpful, but they primarily focus on social- communication symptoms and can neglect the consequences of repetitive behaviors on the daily activities of children and families. The overall goal of this project is to determine whether a new form of family-based treatment for repetitive behaviors, delivered using videoconferencing technology, can counter any negative effects of repetitive behavior, but also improve positive outcomes for young children with ASD.

PI_NAMEs: BOYD, BRIAN ANTONIO (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acute;Aftercare;Anxiety;anxiety symptoms;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Behavioral;behavioral study;Caregivers;Caring;Categories;Cellular Phone;Child;Child Behavior;child services;Clinical Treatment;communication behavior;comorbidity;comparison group;COVID-19;COVID-19 pandemic;Cues;design;Distal;Education;Educational process of instructing;effective therapy;Effectiveness;Environment;Ethnic Origin;experience;falls;Family;Feeling;flexibility;follow-up;Functional impairment;Goals;implementation intervention;improved;interest;Intervention;Intervention Studies;Knowledge;Learning;Link;lower income families;Marital Status;Mediating;Modeling;neglect;neurobehavioral;novel;Outcome;pandemic disease;Parenting Education;Parents;personalized intervention;Persons;Pilot Projects;pilot test;Play;Probability;psychiatric comorbidity;Race;Randomized, Controlled Trials;reduce symptoms;remote delivery;remote intervention;repetitive behavior;Reporting;Research;Rewards;Role;Sample Size;Secure;Services;skills;social communication;Stress;Surveys;Symptoms;Technology;technology intervention;telehealth;Therapeutic;Time;Translational Research;treatment effect;treatment research;treatment response;trial comparing;uptake;Videoconferencing

PROJECT_TITLE: Parent implemented treatment for repetitive behaviors in children with ASD: Using a novel telehealth approach to increase service access


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative: The search for novel strategies to promote both healthspan and lifespan, and identification of validated and effective biomarkers for aging research, are important efforts in geroscience research. As a saliva-enriched novel secretory protein, J18 has the potential to be a biomarker for the aging process. In addition, increasing J18 levels may be a novel strategy to promote both healthspan and lifespan. A new aging biomarker and a novel strategy to promote both healthspan and lifespan will be beneficial in many aspects of geroscience.

PI_NAMEs: ZHAO, SHANGANG  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Academic Training;Address;adiponectin;Adipose tissue;Affect;Age;age-related disease;aged;Aging;aging biomarker;aging population;aging process;Anti-diabetic Drugs;behavior test;Biocompatible Materials;biological age;Biological Assay;Body Weight;Caloric Restriction;career;Cellular biology;cognitive function;cohort;combat;Data;Diet;Disease;disorder risk;Eating;Enzymes;experience;extend lifespan;Family;Fasting;feeding;Functional disorder;Gene Expression;Genes;Geroscience;glucose tolerance;glycosylation;Goals;Health;healthspan;High Fat Diet;high throughput screening;Human;human old age (65+);Hydrolase;impaired glucose tolerance;improved;in vivo;Individual;Infiltration;insight;Insulin Resistance;insulin sensitivity;interdisciplinary approach;interest;International;Knockout Mice;Label;Life Expectancy;life span;Link;Lipids;Liver;Measures;Mediating;Medical center;Mentors;Mentorship;Metabolic;Metabolism;mouse model;Mus;novel;novel strategies;Obese Mice;Obesity;overexpression;Pattern;Pharmacology;Phase;Phenotype;Physiological;Physiology;Positioning Attribute;potential biomarker;predictive marker;Process;Protein Secretion;Proteins;Recombinants;Regulation;Research;Research Personnel;Research Proposals;Rodent;Role;Saliva;Salivary Glands;secretory protein;Testing;Texas;Therapeutic;Time;Tissues;Training;Transgenic Mice;Transgenic Organisms;tumor;Universities

PROJECT_TITLE: Impact of a Novel Secreted Enzyme J18 on Healthspan and Lifespan

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Autism;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pain Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE As we age, accurate pain assessment becomes even more important due to more chronic painful medical conditions and changes in how we experience pain. For autistic adults, communicating about pain may be difficult and result in barriers to adequate pain management and medical care. This project aims to understand how pain may differ for autistic adults to reduce suffering and minimize the effects of mismanaged pain on their lives.

PI_NAMEs: FAILLA, MICHELLE DAWN (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Affect;Affective;Age;Aging;Alzheimer's Disease;Anxiety;Arthritis;autism spectrum disorder;autistic;Back Pain;Caring;Central Nervous System;central sensitization;Chronic;Communication;Communication difficulty;conditioned pain modulation;Coupled;Cross-Sectional Studies;Dangerousness;Data;dementia risk;Development;developmental disease;Diabetes Mellitus;Diagnosis;Dimensions;Disparate;Emotional;experience;Functional Magnetic Resonance Imaging;Goals;Health;health care availability;Health Care Costs;high risk;human old age (65+);Individual Differences;Injury;intense pain;Intervention;Knowledge;Literature;Medical;Mental Depression;multimodality;neural;neural patterning;Pain;Pain Assessment Tool;pain inhibition;Pain intensity;Pain management;Pain Measurement;pain outcome;pain perception;pain processing;Pain quality;pain sensitivity;Pain Threshold;Participant;Pattern;Persistent pain;Polypharmacy;Population;pressure;Protocols documentation;Psychophysics;Quality of life;Race;Reporting;response;Risk;Sensory;sex;Signal Pathway;Site;social communication;Social isolation;Stimulus;success;System;Testing;Work;young adult with autism spectrum disorder

PROJECT_TITLE: Pain sensitivity and endogenous pain modulation in autistic adults

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The CTSA Predoctoral T32 at the University of Michigan will build upon its strong foundation of engaging predoctoral trainees to provide training, education, and mentoring in translational research and science to support their emerging careers. By leveraging the unique strengths of the University of Michigan, building on our robust evaluation program, and adhering to our foundational programmatic elements, we will develop and retain a diverse group of next-generation translational research and science team leaders.

PI_NAMEs: ELLINGROD, VICKI L;HOLINSTAT, MICHAEL ALLAN (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Michigan;pre-doctoral;Universities


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Program Narrative To develop a cadre of talented physician and non-physician investigators devoted to the study of skin biology and skin diseases, we propose a novel training program with a customized curriculum of basic, translational and clinical experiences, individually tailored to each trainee and focused on a specialized skin disease or process; specifically, each curriculum will comprise 1) laboratory-based research, guided by a mentor and committee with diverse strengths and expertise; 2) didactic translational aspects for that research project; and 3) for physician trainees, focused clinical involvement relevant to the disease or process targeted by the research project. In addition to providing our trainees with rigorous scientific instruction in the specific area of their choosing, we shall mentor and guide them to ensure a successful transition to productive academic careers, preparing them for independent dermatology-oriented biomedical research. We propose to engage two trainees trained as physicians or non-physicians into a two-year postdoctoral training program, with a third optional year, for which we have assembled a stellar team of mentors in broad areas relevant to dermatology, and an innovative guidance program to unite the lab-bench, translational and clinical aspects of the training.

PI_NAMEs: ORLOW, SETH J. (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Cutaneous Biology and Skin Disease Training Program


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Molecular Metabolism Training Program (MMTP) at the University of Chicago will train the next generation of researchers specializing in metabolism, who by advancing their scientific skills, knowledge, teaching abilities, innovative ideas and biomedical entrepreneurship will develop new translational approaches for the understanding, prevention, treatment and even cures for metabolic disease. The MMTP is an integrative program that spans departments and includes faculty trainers from throughout the Biological Sciences Division with an active research interest in the study of metabolic diseases and mentoring of pre-doctoral students. Considering the current and ever-increasing worldwide diabetes and obesity epidemics, the MMTP will clearly contribute to public health by supporting the training of highly and broadly skilled junior researchers who will join the national biomedical research workforce to combat metabolic diseases in humans.

PI_NAMEs: BRADY, MATTHEW J (contact);MIRMIRA, RAGHAVENDRA G

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Metabolism;Molecular;Training Programs

PROJECT_TITLE: An Interdisciplinary Molecular Metabolism Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Division of Maternal-Fetal Medicine at Brown University/Women & Infants Hospital of Rhode Island (WIH) with Dwight Rouse, MD, MSPH as Principal Investigator look forward to a high-level of participation in the Eunice Kennedy Shriver NICHD MFMU Network and working toward finding solutions to important obstetric problems such as prematurity and maternal morbidity and mortality.

PI_NAMEs: ROUSE, DWIGHT J (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Clinical Trials;Collaborations;data acquisition;data quality;Discipline of obstetrics;experience;Funding;high standard;Hospitals;Human Resources;Infant;Infrastructure;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Mission;National Institute of Child Health and Human Development;Observational Study;premature;Principal Investigator;Productivity;recruit;Rhode Island;Structure;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Monitoring the progression of multiple sclerosis (MS) has been challenging due to the inconsistency and variability of both clinical and magnetic resonance imaging assessments. This project will develop methods and software for analysis of both optical coherence tomography (OCT) and OCT angiography (OCTA) scans of the retina, both of which show correlation to disability in MS. At the conclusion of the grant, software implementing the methods will be made available to the research community in a highly portable computer language.

PI_NAMEs: PRINCE, JERRY L (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: advanced disease;Affect;Algorithmic Analysis;Algorithms;Anatomy;Angiography;automated algorithm;Bayesian Modeling;Behavior;Biological;Biological Markers;burden of illness;Central Nervous System Diseases;cerebral atrophy;Clinic;Clinical;clinical biomarkers;cohort;Communities;Compensation;Computational algorithm;Computer software;Computers;convolutional neural network;cost;Data;deep learning;density;Development;Diagnosis;diagnostic tool;disability;Disease;Disease Management;Disease Progression;efficacy evaluation;Endothelium;Equilibrium;Esthesia;Evaluation;Event;experience;Eye;Eye diseases;Failure;Foundations;Four-dimensional;Future;ganglion cell;Grant;Graph;gray matter;Image;image processing;imaging biomarker;Imaging Device;imaging modality;imaging Segmentation;improved;Individual;insight;Language;Learning;learning progression;Literature;Longitudinal Studies;Machine Learning;macula;macular edema;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Methodology;Methods;Modeling;Monitor;Morphologic artifacts;Multiple Sclerosis;multiple sclerosis patient;Muscular Atrophy;Nervous System Disorder;Neurodegenerative Disorders;novel;novel diagnostics;open source;Optical Coherence Tomography;portability;Process;random forest;recursive neural network;Relapse;Research;research clinical testing;Retina;retina blood vessel structure;retinal imaging;Role;Sampling;Scanning;segmentation algorithm;Severities;Source;Spinal Cord Lesions;Technology;technology development;Testing;Text;Thick;Thinness;three dimensional structure;Time;tool;Training;treatment choice;Variant;Vision;Visit;white matter

PROJECT_TITLE: OCT and OCTA image processing for retinal assessment of people with MS


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Clinical Research;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative Sub-Saharan Africa is home to 90% of the 300,000 children born worldwide with Sickle Cell Disease (SCD) annually and SCD in Sickle Cell Anemia SSA is associated with 16% of childhood mortality . The proposed program will seek to enhance the SCD associated NCD human resource for research capacity in Uganda. It is anticipated that by the end of the 5-years support, a critical mass of local research scientists will have been created to support the further growth of a high quality SCD associated NCDs research and clinical care portfolio, focused on low-cost sustainable interventions for SCD affected populations. 1

PI_NAMEs: KIGULI, SARAH  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accounting;acute chest syndrome;Acute Renal Failure with Renal Papillary Necrosis;Adult;Advocacy;Affect;Africa;Africa South of the Sahara;Brain;Cessation of life;Child;Childhood;Chronic;clinical care;college;cost;Disease;Growth;health related quality of life;Health Sciences;Heart;High Prevalence;Home;innovation;Intervention;Kidney;Life Expectancy;life span;Lung;Microalbuminuria;Morbidity - disease rate;mortality;multidisciplinary;Neurocognitive Deficit;Nutritional;Patients;Perinatal;Persons;Population;Professional Education;Research;Research Training;Scientist;Sickle Cell Anemia;Stroke;Survivors;Training;Uganda;Universities;Work

PROJECT_TITLE: Enhancing Research capacity for Sickle Cell Disease and related NCDs across the Lifespan in Uganda. ''Enrich Project''


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Maintaining proper ion transport is a vital function of the airway epithelium, as it is a necessity for proper moistening and protection of the airways through airway surface liquid and mucociliary clearance. Dysregulated ion transport and impaired mucociliary clearance underlie cystic fibrosis and, to some extent, COPD and asthma. We will define the contribution of different unique rare airway epithelial cell types to overall ion transport of the epithelium, examine alterations in their function during modeling of disease states, and clarify the potential of targeting ion transport in specific cells for the treatment of airway diseases.

PI_NAMEs: BRATCHER, PRESTON E (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Active Ion Transport;Affect;Airway Disease;airway epithelium;Airway Resistance;airway surface liquid;Animals;Asthma;bronchial epithelium;Cell Count;cell type;Cells;Chronic;Chronic Obstructive Pulmonary Disease;Cilia;common treatment;Communication;Complex;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis patients;defined contribution;Development;Disease;disease model;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Epithelium;Equilibrium;Exons;Frequencies;Functional disorder;Future;Gene Mutation;Health;Human;human model;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;improved;Individual;Inherited;innovation;intercellular communication;Ion Channel;Ion Transport;Ions;Irritants;Knock-out;Liquid substance;Lower respiratory tract structure;Lung;Lung Compliance;Maintenance;Measures;Mediating;Membrane;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mucociliary Clearance;Mucous body substance;Mus;Mutation;Nasal Epithelium;Neuroendocrine Cell;Nose;novel;particle;Passive Ion Transport;pathogen;Play;Process;promoter;Property;Regulation;Research;Respiration Disorders;Respiratory System;response;Rest;Role;Severity of illness;Signal Transduction;single-cell RNA sequencing;Site;Stimulus;Structure;Surface;targeted treatment;Techniques;Technology;therapeutic development;Time;Tissues;Trachea;Tracheal Epithelium;Transcript;transcription factor;Upper respiratory tract;Viscosity;Water Movements

PROJECT_TITLE: Contribution of pulmonary ionocytes and neuroendocrine cells to ion transport-mediated airway surface liquid maintenance

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative This project will develop new tools to assess contributions of the LINE-1 (L1) retrotransposon to somatic mosaicism in normal human tissues. Advances here will allow investigators to characterize L1 insertions genome-wide using state-of-the-art long-read and single cell technologies. If successful, the project will enable the Somatic Mosaicism across Human Tissues (SMaHT) Network to develop more complete catalogs of genetic variation in tissues.

PI_NAMEs: BERNSTEIN, BRADLEY EVAN;BURNS, KATHLEEN H (contact);LEE, EUNJUNG ALICE

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3' Flanking Region;Admixture;Benchmarking;Biological Assay;Biology;Cataloging;Catalogs;Cell Nucleus;Cells;Cellular Assay;Code;Complement;Complementary DNA;computational pipelines;Coupled;Data;Data Analyses;data analysis pipeline;Detection;Development;Disease;DNA;DNA Insertion Elements;DNA Transposable Elements;Elements;Epigenetic Process;Event;experience;Gene Frequency;genetic variant;Genetic Variation;Genome;genome-wide;Genomic DNA;genomic locus;genomic tools;Genomics;Goals;Heritability;High-Throughput Nucleotide Sequencing;Human;Human Genetics;human tissue;Hybrids;In Situ;Inherited;innovation;instrument;Laboratories;Long Interspersed Elements;Malignant Neoplasms;Maps;method development;Methods;Methylation;Molecular Biology;Molecular Computations;Mosaicism;multidisciplinary;nanopore;Normal tissue morphology;Phase;Population;Procedures;Production;promoter;Proteins;Quality Control;Reaction;Repression;Research Personnel;Retrotransposition;Retrotransposon;Reverse Transcription;RNA;scale up;Sensitivity and Specificity;single cell technology;single molecule;Single Nucleotide Polymorphism;Site;Somatic Mutation;Sorting;Source;Standardization;Technology;technology development;Tissues;tool;tool development;transposon sequencing;Validation;Variant;variant detection;whole genome

PROJECT_TITLE: Single Molecule Detection of L1 Insertions and Intermediates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance This project will lead to a better understanding of the basis of a fundamental feature of asthma called airway hyperresponsiveness and is designed to discover novel molecular targets to prevent the onset and/or progression of asthma.

PI_NAMEs: HALLSTRAND, TEAL S (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 3-Dimensional;Address;Air;airway epithelium;airway hyperresponsiveness;Allergens;Allergic;Asthma;asthma model;asthmatic airway;Cell Physiology;Cells;Cellular biology;Child;Chymase;Coculture Techniques;Cross-Sectional Studies;cytokine;design;Development;Disease;Disease Progression;Dryness;Effector Cell;Epithelial Cells;Epithelium;Exercise;Gene Expression;Genomic approach;Goals;House Dust Mite Allergens;Immune response;immunopathology;in vivo;in vivo Model;Individual;Infiltration;Inflammation;intraepithelial;Lead;Link;lipid mediator;Location;mast cell;Mediating;Mediator;Modeling;Molecular;Molecular Target;mouse model;novel;Osmosis;Patients;peripheral blood;Phenotype;Population;Predisposition;prevent;progenitor;proliferation potential;Pyroglyphidae;quantitative imaging;receptor;recruit;Research;respiratory examination;respiratory imaging;response;Sampling;Severities;Source;stem cells;Submucosa;Three-Dimensional Imaging

PROJECT_TITLE: Origin and Function of Intra-epithelial Mast Cells in Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed project will investigate why children with COPB2-related disorder have osteoporosis and bone fractures. Results from this study will assist in developing better diagnostic approaches and therapies for these patients and will provide insights relevant to other genetic disorders that affect protein secretion.

PI_NAMEs: MAROM, RONIT  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acids;Advisory Committees;Affect;American;Autophagocytosis;Basic Science;Biochemical;Biogenesis;Biological Assay;Biological Models;Biometry;Body System;bone;Bone Development;bone fragility;bone mass;career;career development;Carrier Proteins;Cell Cycle;Cell Physiology;Cells;Certification;Child;Childhood;Clinical;Collagen;college;Complement;Complex;conditional knockout;Data;Defect;Deposition;design;Development;Development Plans;Developmental Delay Disorders;Diagnostic;diagnostic strategy;diagnostic value;Disease;Doctor of Medicine;Doctor of Philosophy;Electron Microscopy;Embryo;endoplasmic reticulum stress;Enterobacteria phage P1 Cre recombinase;Ethics;Etiology;Exhibits;experience;experimental study;Extracellular Matrix Proteins;Failure;Fracture;Functional disorder;Future;Genes;Genetic Diseases;Genomics;Glycols;glycoproteomics;glycosylation;Goals;Golgi Apparatus;Grant;Heterozygote;Histology;Human;Human Genetics;immunodeficiency;In Vitro;in vivo;Individual;insight;Intellectual functioning disability;Kinetics;Knockout Mice;Laboratories;Laboratory Research;Leadership;Learning;Lectin;Lipids;live cell microscopy;loss of function;Medical Genetics;Medicine;meetings;Mentors;Mentorship;microCT;microscopic imaging;model organism;Modeling;Molecular Genetics;molecular phenotype;mouse model;multimodality;Mus;Organelles;osteoblast differentiation;Osteoblasts;Osteogenesis Imperfecta;Osteopenia;Osteoporosis;Other Genetics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physicians;Polarization Microscopy;Procollagen;Protein Glycosylation;Protein Secretion;protein transport;Proteomics;proteostasis;rare mendelian disorder;Recurrence;Research;Research Design;Role;Scientist;screening;skeletal;skeletal abnormality;Skeletal Development;skeletal dysplasia;Skeletal system;Skeleton;skills;Sorting;Stains;Structure;symposium;System;targeted treatment;Technology;Testing;Time;Tissues;trafficking;Training;transcriptomics;Transgenic Organisms;translational impact;Translational Research;treatment strategy;Variant;Vocational Guidance;Work;Writing;Zebrafish

PROJECT_TITLE: ELUCIDATING THE ROLE OF COATOMER COMPLEX COPI IN SKELETAL DYSPLASIA

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Sympathetic nervous system activity is increasingly appreciated as a major contributor to pulmonary hypertension severity and prognosis. Our studies focus on neuronal-immune cell interactions that seek to uncover the mechanism involved in disease-associated sympathetic activity. We focus in part on a subset of TREM2 expressing disease-associated microglia as a therapeutic target for the treatment of pulmonary hypertension and its associated end-organ damage.

PI_NAMEs: OLIVEIRA, ALINE CRISTINA (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Ablation;Animal Model;Area;Arrhythmia;Attenuated;attenuation;Brain;Brain region;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;Cell Communication;Cells;Central Nervous System;Cessation of life;Chronic;Data;Death Rate;Development;Disease;Disease associated microglia;drug development;Dysautonomias;Epigenetic Process;Etiology;Evaluation;experience;Experimental Models;experimental study;Exposure to;Flow Cytometry;Functional disorder;Gene Expression;gene function;Genetic Models;Genetic Techniques;Goals;Heart;Hematopoietic;Hematopoietic stem cells;Hypothalamic structure;hypoxia-induced pulmonary hypertension;Immune;Immunohistochemistry;improved;Induced Neurons;Infiltration;Inflammatory;innovation;insight;Knockout Mice;Lung;member;Mentors;Mentorship;Methodology;Microglia;Mus;Myelogenous;Myeloid Cells;Neuroanatomy;Neuroimmune;neuroinflammation;Neuronal Plasticity;Neurons;neurotransmission;novel;Nucleus solitarius;Organ;Outcome;Output;paraventricular nucleus;Pathogenicity;Patients;Pharmacotherapy;Phase;Phenotype;Predisposing Factor;professor;Prognosis;programs;Progressive Disease;Publishing;Pulmonary Hypertension;Research;respiratory;right ventricular failure;Scientist;Series;Severities;single-cell RNA sequencing;Slice;Sympathetic Nervous System;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Training;TREM2 gene;two photon microscopy;Up-Regulation;vasoconstriction;Ventricular Dysfunction

PROJECT_TITLE: Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative This grant, RFA-HL-19-009 is directly relevant to the core NHLBI mission of improving public health in the United States by the following: 1) Development of new evidence based cardiovascular decision making in multiple areas of cardiac surgery and cardiovascular disease through the use of randomized and other novel clinical research trial tools 2) The development of new generation of clinical researchers interested in implementation science in cardiac surgery 3) The mentorship of a center in an area of the country with high prevalence of cardiovascular disease that is underserved such as the Mississippi Valley.

PI_NAMEs: DESAI, NIMESH D (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Affect;American;Applications Grants;Area;Arkansas;attributable mortality;Biometry;Cardiac;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular Surgical Procedures;Cardiovascular system;Clinical;clinical center;clinical implementation;Clinical Research;Clinical Trials;Collaborations;Communities;Coronary heart disease;Country;Death Rate;Decision Making;design;Development;Enrollment;Ensure;Environment;Epidemiology;evidence base;experience;Faculty;Fostering;Future;Generations;Goals;Grant;Health;Health Policy;Health Sciences;Heart Diseases;High Prevalence;Hot Springs;implementation research;implementation science;improved;innovation;Institution;interest;Knowledge;Leadership;Link;medical schools;Medical Students;Mentors;Mentorship;Mission;Mississippi;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Nature;novel;Nurses;Operative Surgical Procedures;Pennsylvania;Population;programs;prospective;Public Health;Randomized;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Scholars Program;Scientist;Site;skill acquisition;skills;Specialist;statistics;Stroke;Students;success;Surgeon;synergism;tool;Training;Translational Research;United States;Universities

PROJECT_TITLE: Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Contraception/Reproduction;Genetics;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Abnormal fetal growth affects ~15% of all babies and increases the risk for injuries at delivery and to develop obesity, diabetes, and cardiovascular disease in childhood and later in life. Unfortunately, the understanding of the causes of these conditions is limited and no effective treatments are available. We will develop novel experimental models to determine the role of changes in placental transport of amino acids in regulating placental function and determining fetal growth, which will help us better understand the causes of abnormal fetal growth and may lead to novel treatments for these pregnancy complications.

PI_NAMEs: BROWN, THOMAS L;JANSSON, THOMAS  (contact);URSCHITZ, JOHANN

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: adenoviral mediated;Adult;Affect;Amino Acid Transport System A;Amino Acid Transport System L;Amino Acid Transporter;Amino Acids;Animal Model;Animals;Biological Assay;blastocyst;Blastocyst Transfer;Blood Pressure;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;Cells;Child;Childhood;Complement;Defect;Development;Diabetes Mellitus;Disease;Doxycycline;Echocardiography;effective therapy;Embryo;Embryo Transfer;Essential Amino Acids;Experimental Models;Family;Fetal Growth;Fetal Growth Retardation;Fetal Macrosomia;Folic Acid;FRAP1 gene;Gene Expression;Gene Targeting;Gene Transfer;Gene Transfer Techniques;Genes;Gestational Diabetes;glucose tolerance;Human;in vivo;Injury;Insulin Resistance;islet;knock-down;Knock-out;Labyrinth;lentivirally transduced;Lentivirus;Life;Link;Measures;Mediating;member;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;Mus;Mutant Strains Mice;novel;novel strategies;Nutrient;Nutritional;Obesity;offspring;Outcome;overexpression;perinatal morbidity;Perinatal mortality demographics;Placenta;placental transfer;Placentation;Pregnancy;Pregnancy Complications;programs;promoter;Protein Biosynthesis;Protein Isoforms;Regulation;Resolution;Respiration;Risk;Role;Signal Transduction;Small Interfering RNA;solute;Spirometry;System;Techniques;Telemetry;Testing;Thyroid Hormones;Time;tool;Transduction Gene;Transfection;Transposase;trophoblast;uptake;Western Blotting;Woman

PROJECT_TITLE: Development of approaches for inducible trophoblast-specific gene modulation: the role of trophoblast Lat1 in the regulation of placental function and fetal growth

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: PROJECT SUMMARY/ABSTRACT Malaria continues to kill more than 400,000 people yearly. Recently a group of viruses, the Matryoshka RNA viruses (MaRNAV), has been identified that is associated with the human pathogen Plasmodium vivax, and also the distantly related avian pathogen Leucocytozoon. Thus, it is clear that these viruses are ancient in their origin, but nearly nothing is known about their affects on malaria- infected hosts. We will test the hypothesis that the Matryoshka RNA viruses have a deep evolutionary history, and can affect the pathogenicity of malaria parasites. Using a bioinformatics approach, we will compare the transcriptomes of avian malaria pathogens and identify the prevalence and diversity of these viruses. We will also seek to understand how malaria infections affect specific components of the avian immune response. The proposed research is timely and significant in that it will advance the field of malaria research by providing important information about the evolution of the immune response to this common parasite. This work is innovative because birds provide the only model system where the MaRNAV viruses can be easily studied in natural populations infected by a diverse group of haemosporidian parasites. The long-term and cross-disciplinary goal of this research agenda is to elucidate the evolution of malaria pathogenicity and identify conserved viruses and immune responses that may be overlooked using mammalian model systems. The aims of the proposal are to: 1. Sequence the complete transcriptomes of select birds to determine the prevalence and diversity of malaria-associated viruses. 2. Characterize differences in immune responses between malaria- infected and non-infected avian hosts. 3. Determine whether malaria-associated viruses alter the host immune response to parasite infection. The project will support the education of future scientists through an integrative approach to research and education. It will train students in cutting edge technologies associated with infectious disease research, and provide valuable experiences for graduate and undergraduate students at an urban university serving large numbers of students traditionally underrepresented in the sciences. The developmental objectives of the PI will be met by working with outstanding collaborators, which will further his training in the molecular genetics of malaria.

PI_NAMEs: SEHGAL, RAVINDER NATH MARIUS (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Admission activity;Affect;Avian Malaria;Bioinformatics;Biological Models;Biomedical Research;Birds;Blood;career;Collaborations;Culicidae;Development;Disease;Distant;Doctor of Philosophy;Education;Epidemiology;Evolution;expectation;experience;fitness;Future;Gene Expression;Goals;graduate student;Health;High-Throughput Nucleotide Sequencing;Human;human pathogen;Immune response;Immune Response Genes;infected vector rodent;Infection;Infectious Diseases Research;innovation;Insecta;Laboratories;Malaria;malaria infection;Methods;Modeling;Molecular Genetics;next generation sequencing;Parasitemia;Parasites;Parasitic infection;pathogen;Pathogenicity;Persons;Phylogeny;Plasmodium;Plasmodium gallinaceum;Plasmodium vivax;Population;Prevalence;programs;Publishing;Recording of previous events;Research;response;RNA Viruses;Satellite Viruses;Science;Scientist;Sporozoites;student training;Students;System;Technology;Testing;Training;transcriptome;transcriptome sequencing;undergraduate student;underrepresented minority student;Universities;Virus;wild bird;Work

PROJECT_TITLE: Molecular Genetics of Avian Malaria Viruses


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Drug-Excipient nanoparticles have unprecedented drug loading and are rapidly synthesized and designed using machine learning but cannot yet be functionalized to enable active targeting. Here, we will invent computational and experimental protocols to design and characterize novel Antibody-Drug- Excipient nanoparticles with designer tissue targeting in vivo. The developed platform will enable the efficient creation of highly loaded nanoparticles for various indications and tissues and serve as a blueprint for future research and development into machine learning-assisted drug delivery and biomaterial design.

PI_NAMEs: REKER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Antibodies;antibody libraries;Behavior;Biocompatible Materials;Cells;clinical development;clinically relevant;cluster computing;combinatorial;Complex;computational pipelines;Computer Models;design;Development;Drug Combinations;Drug Delivery Systems;Drug Design;Drug Targeting;Evaluation;Excipients;experience;Fc domain;FDA approved;Generations;Goals;High Performance Computing;Hydrophobicity;improved;In Vitro;in vivo;innovation;insight;invention;Laboratories;Libraries;Machine Learning;manufacture;Modeling;Molecular;Molecular Computations;nanoformulation;nanomedicine;nanoparticle;new technology;novel;novel therapeutics;Outcome Study;Pharmaceutical Preparations;Positioning Attribute;precision drugs;preservation;Protocols documentation;prototype;rational design;Research;research and development;Research Proposals;Safety;simulation;Surface;Testing;Therapeutic;therapeutic nanoparticles;Time;Tissues;Translations;Treatment Efficacy;uptake;Vaccines

PROJECT_TITLE: Computational Design of Antibody-Drug-Excipient Nanoparticles

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


PHR: PROJECT NARRATIVE Prostate cancer is the second most common cause of cancer death among men. Alterations in androgen receptor signaling are pervasive in advanced prostate cancer. This proposal seeks to understand the mechanisms that regulate the androgen receptor with the goal of inspiring novel prostate cancer therapeutic strategies.

PI_NAMEs: VISWANATHAN, SRINIVAS RAGHAVAN (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Ablation;advanced prostate cancer;Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;antagonist;Architecture;Arginine;Automobile Driving;Binding;Biological Process;Cancer Etiology;Castration;Cause of Death;Cell Line;Cells;Cessation of life;Chromatin;Clinical;clinical development;cofactor;Combined Modality Therapy;Complex;CRISPR screen;curative treatments;Data;Data Set;Disease;Enhancers;Enzymes;Epigenetic Process;experimental study;genetic corepressor;Genetic Screening;Genetic Transcription;genome-wide;Genomics;Goals;histone modification;Hormone Receptor;hormone therapy;Hormones;human disease;improved outcome;In Vitro;in vivo;in vivo Model;inhibitor;insight;Knock-in;Malignant neoplasm of prostate;Mediating;men;Methylation;Modeling;Modification;Molecular;next generation;novel;novel strategies;novel therapeutic intervention;Output;Pathogenesis;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phase;Post-Translational Protein Processing;posttranscriptional;pre-clinical;programs;prostate cancer model;Protein-Arginine N-Methyltransferase;Proteins;receptor;receptor expression;Receptor Signaling;Regulation;Reporter;Resistance;Resistance development;Role;Site;small molecule inhibitor;Specimen;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Treatment Efficacy;United States;Work

PROJECT_TITLE: Regulation of androgen receptor signaling in prostate cancer by protein arginine methylation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE  The persistent activation of the androgen receptor signaling pathway has been observed in primary prostate cancer (PCa) as well as aggressive prostate cancer including castration-resistant prostate cancer (CRPC) or drug-resistant prostate cancer. Methylation of adenosine at nitrogen-6 position (m6A) on RNA molecules have been implicated to the pathogenesis of PCa through abnormal alteration of m6A levels deposited by METTL3, which is m6A methyltransferase. Our proposed studies aim to understand how the m6A modification and nuclear m6A reader YTHFC1 mediate the transcriptional activation of androgen receptor (AR), which is critical to the pathogenesis of PCa, and how the persistent activation of AR signaling in castration- or drug-resistant prostate cancer is associated with biomolecular condensation. This study will evaluate and propose the clinical potential of pharmacological inhibition on m6A deposition in the PCa pathogenesis-associated transcriptional regulation through AR.

PI_NAMEs: LEE, JIHOON  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: abiraterone;Address;Adenosine;advanced prostate cancer;Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;antagonist;Binding;Biological Assay;Biological Process;cancer diagnosis;Cancer Patient;cancer survival;Castration;Cessation of life;ChIP-seq;Chromatin;Clinical;Complex;Data;Deposition;Development;Disease;drug relapse;Drug resistance;drug resistance development;Enhancers;enzalutamide;experimental study;gain of function;Gene Expression;gene repression;Genetic Enhancer Element;Genetic Transcription;genome-wide;Goals;Growth;Hormones;Human;human disease;Link;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Methylation;methylome;Methyltransferase;Modification;Molecular;mouse model;Mutation;Nitrogen;novel therapeutic intervention;Nuclear;Oncogenic;Pathogenesis;patient derived xenograft model;pharmacologic;Phase;Phenotype;Physical condensation;Play;Positioning Attribute;Prostate;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Proteins;Reader;receptor binding;receptor function;Receptor Signaling;receptor-mediated signaling;Regulation;Regulator Genes;Relapse;Reporting;Resistance;RNA;RNA Splicing;Role;Signal Pathway;Site-Directed Mutagenesis;Testing;Therapeutic;Transactivation;Transcriptional Activation;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translations;Treatment Failure;tumor;United States;Untranslated RNA;Xenograft procedure

PROJECT_TITLE: The role and mechanism of RNA m6A modification in the pathogenesis and drug-resistance of prostate cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Sarcoidosis

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE  Immune dysregulation is a key mediator of pathogenesis in sarcoidosis. The pathogenic formation of granulomas in the disease is not well understood. This proposal will study how the pathological immune environment drives granuloma formation and disease progression through a single-cell multi-omic approach.

PI_NAMEs: HUANG, KAI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Albumins;anergy;Area;Atlases;Bacillus;Bioinformatics;Biological Assay;Biological Markers;Biomedical Engineering;Cell Communication;cell type;Cells;Cellular Assay;Cessation of life;Clinical;combinatorial;comparison control;Complex;Cutaneous Sarcoidosis;cytokine;Data;design;Development;Diagnosis;Disease;Disease Progression;drug discovery;Drug Modelings;Drug Screening;Environment;Etiology;Evaluation;Fostering;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;gene network;Genes;Granuloma;Granuloma by Site;Granulomatous;Granulomatous disease;Healthcare;Hyperactivity;Immune;immune function;Immune system;Immune System Diseases;Immunology;immunoregulation;Immunosuppressive Agents;improved;In Vitro;in vitro Model;indexing;Inflammatory;interdisciplinary approach;Interdisciplinary Study;Laboratories;Lesion;Life;Maintenance;Mediating;Mediator;model design;Modeling;Morbidity - disease rate;multidisciplinary;multiple omics;Organ;Pathogenesis;Pathogenicity;Pathologic;Pathway Analysis;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Physicians;Play;Population;prevent;Process;Proteins;Regulation;Regulatory T-Lymphocyte;Research;Rheumatoid Arthritis;Role;Sampling;Sarcoidosis;Scientist;screening;single-cell RNA sequencing;skin biopsy;Specificity;symptom management;Symptoms;T-Lymphocyte;Techniques;theories;Tissues;Toxic effect;Training;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;tuberculin purified protein derivative;tumor immunology;Work

PROJECT_TITLE: Immune Dysregulation in Sarcoidosis


NIH_SPENDING_CATS: Clinical Research;Lung

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE With the COVD-19 pandemic, we are keenly aware of the impact of airway inflammation, which is mediated by pro-inflammatory cytokines such as TNFα. Inflammation is a key aspect of airways diseases such as asthma that affect more than 20 million people in the USA and 300 million people worldwide. The proposed studies will focus on human airway smooth muscle (hASM) and the effects of pro-inflammatory cytokines in inducing stress on the endoplasmic reticulum (ER). In hASM cells, we will explore the involvement of TNFα in selectively activating an ER stress signaling cascade, and how this affects the downstream expression of proteins that regulate mitochondrial structure and function.

PI_NAMEs: PRAKASH, Y. S. ;SIECK, GARY C. (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Acute;Affect;Airway Disease;airway inflammation;Asthma;Awareness;Biogenesis;Chemicals;Consumption;Contractile Proteins;COVID-19 pandemic;cytokine;density;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Experimental Designs;Failure;Generations;Goals;Human;Individual;Inflammation;Inflammatory;Inositol;knock-down;loss of function;Mediating;meetings;Messenger RNA;Mitochondria;Molecular Chaperones;Muscle Mitochondria;mutant;novel;overexpression;Oxidative Stress;pandemic disease;Parkin;Pathway interactions;Persons;Phosphorylation;PINK1 gene;Plasmids;Predisposition;protein expression;Proteins;Reactive Oxygen Species;Research;respiratory;Respiratory Disease;respiratory smooth muscle;response;RNA Splicing;Signal Transduction;Site;Small Interfering RNA;Smooth Muscle Myocytes;Stress;Structure;Testing;TNF gene;Transfection;Ubiquitination;XBP1 gene

PROJECT_TITLE: Impact of Airway Inflammation on Mitochondria


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Neurosciences;Pain Research;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Project Narrative Cancers consist of a mixture of cell types that together promote tumor growth and disease progression; nerves are a newly recognized component of cancers. In this application, we show that intra-tumoral nerves are transcriptionally and functionally different from normal nerves, that disease-associated oncogenes influence these differences and will identify how these differences contribute to cancer pain. In addition, we will define whether drugs that block pain also inhibit tumor growth and improve survival.

PI_NAMEs: VERMEER, PAOLA DRAPKIN (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Afferent Neurons;Alcohols;Animals;Attenuated;Beds;Biological Assay;C57BL/6 Mouse;Cancer cell line;Cancer Control;cancer pain;Cancer Pain Management;cancer survival;Cancerous;carcinogenesis;CCND1 gene;Cell Line;cell type;Characteristics;Clinical Trials;comorbidity;Data;defined contribution;Disease;Disease Progression;Drug Controls;Drug Targeting;Early Intervention;Electrophysiology (science);experimental study;extracellular vesicles;Face;Female;Future;Genetic Transcription;Growth;Guidelines;Head and Neck Cancer;head and neck cancer patient;HPV negative;HPV positive;HPV-High Risk;Human Papillomavirus;Implant;implantation;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Infection;Injections;Lidocaine;male;Malignant Neoplasms;Mediating;MicroRNAs;Molecular;Mus;Mutation;Nerve;nerve supply;Neurites;Neurons;Nociceptors;Oncogenes;Opiate Addiction;Opioid;Oral;Orofacial Pain;Outcome Study;overexpression;Pain;Pain management;Pain Measurement;Papillomavirus Infections;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Predictive Value;premalignant;Prognostic Factor;Publishing;Questionnaires;recruit;Recurrent disease;Reporting;response;Risk;Sampling;Screening procedure;Sensory;Severities;sex;Signal Transduction;Slice;Smoking;Solid Neoplasm;stable cell line;Stimulus;Testing;Time;Toxic Environmental Substances;Tracer;transcriptome sequencing;Transgenic Animals;Transgenic Mice;TRPV1 gene;tumor;tumor growth;Tumor Promotion;Tumor Tissue;vesicular release

PROJECT_TITLE: Intra-tumoral neurons contribute to head and neck cancer pain


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative The project is relevant to public health because it will lead to a new type of immunotherapy for cancer. The proposed studies would investigate the therapeutic potential of pHLIP-phosphoantigen peptide-small molecule conjugates as well as assess potential toxicity issues that may arise. These studies will advance towards clinical application of novel anti-cancer agents designed to specifically deliver immune cell antigens to tumor cells.

PI_NAMEs: BAHAL, RAMAN ;WIEMER, ANDREW J (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Acetates;Address;Agonist;Alanine Transaminase;Alcohols;alpha-beta T-Cell Receptor;analog;Animal Cancer Model;Animal Model;Animal Testing;anti-cancer;Antibodies;Antigens;Aspartate Transaminase;Beta Cell;Binding;Biological;Biological Assay;biophysical analysis;butyrophilin;cancer cell;cancer immunotherapy;cancer therapy;Cancerous;Cell Line;Cell membrane;Cell model;Cells;Cellular immunotherapy;checkpoint therapy;chemical synthesis;chemotherapy;Circular Dichroism;Clinical;clinical application;clinical development;Coculture Techniques;cytokine;Cytoplasm;Cytoplasmic Tail;D Cells;design;Development;Dose;Drug Carriers;Drug Targeting;Effectiveness;Environment;Enzyme-Linked Immunosorbent Assay;Esters;Exhibits;experimental study;Failure;Fluorescence;Follicular Lymphoma;Goals;High Pressure Liquid Chromatography;Histology;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Stimulation;Immunologics;Immunotherapy;immunotoxicity;improved;in vivo;in vivo Model;Infiltration;Integral Membrane Protein;large cell Diffuse non-Hodgkin's lymphoma;Ligand Binding;Ligands;Link;liver function;Luciferases;Lymphoma;Lymphoma cell;Maleimides;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Methods;Monitor;mouse model;Mus;nanomolar;neoplastic cell;Normal Cell;novel;novel anticancer drug;Oxygen;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;phosphonate;Phosphorus;Physiological;Plasma;prevent;Production;Proteins;Public Health;Quality Control;Reaction;receptor;refractory cancer;Research;Resistance;response;Role;Sarcoma;Serum;small molecule;Solid Neoplasm;Specificity;success;Sulfhydryl Compounds;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;Transplantation;Tryptophan;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;γδ T cells

PROJECT_TITLE: Development of pHLIP-phosphoantigen conjugates for lymphoma therapy


NIH_SPENDING_CATS: Aging;Microbiome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative The molecular mechanisms underlying mammalian tissue aging remains largely unknown. The proposed studies will investigate a new mechanism associating beta-catenin signaling and microbiota with the physiologic aging process of intestinal stem cells of both mice and humans. The study results may lead to future therapeutic interventions preventing or reversing tissue aging.

PI_NAMEs: ZHENG, YI  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Adult;adult stem cell;Affect;Age;age related;age related decline;aged;Aging;aging process;aging related;Architecture;Attenuated;base;beta catenin;Biological Assay;Blood;Cell Aging;cell type;Cells;Clinic;crypt cell;Data;design;Deterioration;Endothelial Cells;Family;functional decline;Future;Gene Expression;Gene Modified;gut microbiota;Hematopoietic;Homeostasis;Human;human old age (65+);In Vitro;in vivo;Intestines;Laboratories;life span;Ligands;Link;Measurable;member;Mesenchyme;microbial;microbiota;Molecular;Mus;Muscle;Natural regeneration;novel;old mice;Organ;Organoids;Paneth Cells;Phenotype;Physiological;Play;prevent;progenitor;Proliferating;Regenerative capacity;response;Role;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Skin;stem cell aging;stem cell function;stem cells;Therapeutic Intervention;Tissues;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: Novel mechanism of intestinal stem cell aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CAMBRIDGE

ORG_NAME: CAMBRIDGE HEALTH ALLIANCE

PHR: PROJECT NARRATIVE- Cambridge Health Alliance ALACRITY for Early Screening and Treatment of High Risk Youth (eSToRY)  Barriers to quality mental health care for youth at risk of mental illness are well recognized but persistent, especially among racial, ethnic, and language (REL)-minority youth. The proposed Center for Early Screening and Treatment of at-Risk Youth (the eSToRY Center) is dedicated to research and training to improve early detection of mental illness, to prevent adverse outcomes, to improve quality of care, and to foster equity in treatment for REL-minority youth. We leverage a sophisticated health data infrastructure and an interdisciplinary team of experts to adapt, test, and implement evidence-based practices to accelerate mental health care improvements for REL-minority youth populations.

PI_NAMEs: COOK, BENJAMIN LE (contact);WANG, PHILIP S

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Acceleration;access disparities;Address;Adolescent;Adolescent and Young Adult;adverse childhood events;adverse outcome;Age;Age Years;Area;Asian;barrier to care;Black race;Boston;Budgets;care costs;career;Caring;Cause of Death;Child;Child Welfare;Clinic;Clinical;clinical practice;Communities;Community Health;Community Healthcare;community organizations;Community Participation;cooking;cost effective intervention;COVID-19 impact;COVID-19 pandemic;Data;data infrastructure;data integration;data warehouse;Dedications;design;disability;Discrimination;Disparity;disparity reduction;Distress;Early Diagnosis;Early Intervention;early screening;Early treatment;Electronic Health Record;Emergency Care;Equity;ethnic minority;Ethnic Origin;evidence base;Evidence based practice;experience;Face;Family;Food;Fostering;functional improvement;Future;Grief reaction;Haitian;Health Alliance;health care availability;health care service;health data;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;Housing;Improve Access;improved;improved outcome;Individual;innovation;inpatient service;Institutionalization;insurance claims;Internet;Intervention;Justice;Language;Latino;Learning;Life;Limited English Proficiency;Linguistics;Link;Location;Measurement;Medical;mental development;Mental disorders;Mental Health;Mental Health Services;Methods;migration;minority children;Minority Groups;Monitor;Morbidity - disease rate;Neighborhoods;neuropsychiatry;operation;outpatient programs;outreach program;Patients;physical conditioning;Pilot Projects;Police;Population;population health;Portuguese;Predictive Analytics;prevent;Prevention;Preventive;Psyche structure;Psychiatry;Psychopathology;Public Health;Quality of Care;Race;racial minority;Randomized, Controlled Trials;Research;Research Project Grants;Risk;Schools;screening;screening program;Services;Site;social disparities;social health determinants;Spanish;Stress;suicidal;Suicide;Symptoms;System;Testing;Time;Training;Translating;Treatment Effectiveness;Unemployment;Urban Community;Violence;Work;Youth


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COOK, BENJAMIN LE (contact)

PROJECT_TERMS: Adolescent and Young Adult;Beneficence;Boston;Child;Cities;Clinic;Clinical;clinical practice;Clinical Research;Clinical Services;clinical training;Collaborations;Communities;community based participatory research;community building;community collaboration;Community Participation;Data Collection;data infrastructure;data integration;data management;Data Set;data warehouse;Discipline;Disparity;disparity reduction;Dissemination and Implementation;Doctor of Philosophy;doctoral student;Early identification;Early Intervention;early screening;Early treatment;effective intervention;Equity;Ethnic Origin;Evaluation;experience;Faculty;Food;Foundations;Funding;Grant;Health Alliance;health care disparity;Health equity research;Health Policy;Health Service Area;Health Services;Healthcare;Healthcare Systems;high risk;Hospitals;Human;improved;Information Technology;Infrastructure;innovation;Institution;interest;Intervention;Leadership;Linguistics;Link;Medical;medical schools;Medical Sociology;Medical Students;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;migration;minority children;minority communities;Minority Groups;multidisciplinary;National Institute of Mental Health;Neighborhood Health Center;operation;organizational structure;Pediatrics;Pharmaceutical Preparations;Pilot Projects;Police;Postdoctoral Fellow;pre-doctoral;Predictive Analytics;prevent;programs;Psychiatry;Public Health Schools;Qualitative Methods;Race;Rapid diagnostics;Research;Research Activity;Research Infrastructure;Research Personnel;research study;Research Training;Risk;safety net;Schools;Science;screening;service organization;Site;Specialized Center;Structure;Suicide prevention;System;Teaching Hospitals;Testing;Training;Training Activity;training opportunity;Training Programs;Training Support;Translating;Trauma;United States Dept. of Health and Human Services;United States National Institutes of Health;vulnerable community;Work;Youth

PROJECT_TITLE: Administrative Core for Building Community and Research Opportunities


NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Myelination has recently been identified as a common pathological hallmark of numerous neurodevelopmental and neurodegenerative diseases that present with cognitive symptoms, but how myelin impacts neuronal circuits to influence cognition and behavior remains an open question. This proposal will use novel mouse genetic tools to investigate how myelination influences neuronal circuit function and plasticity in the mammalian cortex. These studies will advance our understanding of circuit modulation by myelination and lay the groundwork for identifying, and eventually developing ways to rectify, the consequences of myelin dysfunction in neurological disease.

PI_NAMEs: XIN, WEN  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Adhesions;Adolescence;Adult;Alzheimer's Disease;area striata;autism spectrum disorder;Axon;Behavior;Cell Physiology;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Cognition;critical period;Data;Dendritic Spines;Development;Electrophysiology (science);experience;experimental study;Foundations;Functional disorder;Genetic;genetic approach;Goals;hippocampal pyramidal neuron;imaging study;improved;in vivo;in vivo two-photon imaging;Individual;Induced Neurons;Injury;Interneurons;Knowledge;Learning;life-long learning;Link;Memory;Mental disorders;Methods;monocular deprivation;mouse genetics;Mus;Myelin;Myelin Sheath;myelination;Nerve Degeneration;nervous system development;Nervous System Disorder;Nervous System Physiology;neural circuit;neural repair;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal circuitry;Neuronal Plasticity;Neurons;neuropathology;novel;Ocular Dominance;oligodendrocyte lineage;Oligodendroglia;orientation selectivity;Parvalbumins;Pathologic;Phase;Play;Population;postsynaptic;presynaptic;Process;programs;Property;Research;Role;Schizophrenia;Scientist;Sensory;serial imaging;Shapes;Silicon;Slice;Specificity;Structure;Study models;symptomatic improvement;Synapses;synaptic function;Synaptic plasticity;Testing;tool;Training;V1 neuron;Visual Cortex;Work

PROJECT_TITLE: Neuronal circuit modulation by myelination in the mammalian visual cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: WASHINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Public Health Relevance Statement There is a severe lack of diversity in the US biomedical science (BMS) workforce especially at the Ph.D. level. A manifestation of this lack is evident by the effect of the COVID-19 on underrepresented minority communities. This pandemic has particularly devastated the Black American communities.

PI_NAMEs: ABERNATHY, SHAWN MAURICE (contact);HARRIS, DINARI A;LEE, CLARENCE M

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic Training;Affect;career;Communities;course development;COVID-19 pandemic;design;Discipline;Doctor of Philosophy;Educational Curriculum;Enrollment;experience;Extramural Activities;Foundations;hands on research;health disparity;health equity;improved;innovation;Institutionalization;interest;Intramural Research;Leadership;Mission;programs;recruit;Research;Research Activity;Research Training;Science;Science, Technology, Engineering and Mathematics;Scientist;STEM field;Structure;Students;summer research;Talents;Training;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States;Universities

PROJECT_TITLE: U-RISE at Howard University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide

PROJECT_TERMS: Acceleration;access disparities;analytical method;Area;behavioral and social science;Bioinformatics;Black race;Boston;Child;Cities;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community based participatory research;Community Health;comorbidity;Comparative Effectiveness Research;Computers;Consultations;cooking;Criminal Justice;Data;Data Collection;data infrastructure;data integration;data platform;Data Set;data warehouse;design;Domestic Violence;Early identification;early screening;Early treatment;Effectiveness;effectiveness evaluation;Electronic Health Record;Equation;Ethnic Origin;Evidence based practice;experience;Family;Felis catus;flexibility;Food;Functional impairment;Future;Grant;Growth;Health;Health Alliance;health care service;health data;health economics;Health education;Health equity research;Health Insurance Portability and Accountability Act;Health Policy;Health Services;Healthcare;Healthcare Systems;Heterogeneity;high risk;high school;improved;Individual;Infrastructure;insurance claims;Internet;Intervention;Investigational Therapies;Language;Leadership;Learning;Letters;Link;Measures;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;minority children;Modeling;Neighborhoods;novel;Pathway interactions;Patients;Pilot Projects;Police;Population;Predictive Analytics;Prevention;Psychiatry;Psychopathology;Publications;Qualitative Methods;Race;Randomized, Controlled Trials;Recovery;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;resilience factor;Resources;Risk;Risk Factors;Schools;Screening procedure;Services;Shelter facility;social health determinants;statistics;Students;suicidal;Suicide;symptomatology;Symptoms;System;Techniques;Teenagers;Testing;Translations;Trauma;treatment effect;Vertebral column;Voice;volunteer;World Health;Youth

PROJECT_TITLE: Methods Core for Study and Data Collection, Design, Support and Dissemination


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Skin Cancer

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE To address increasing skin cancer rates in the US, particularly among young people, we propose to use the Multiphase Optimization Strategy (MOST) to evaluate individual and combined effects of action planning, personalized ultraviolet (UV) photographs, and MC1R genetic testing on preventing sunburn, motivating sun protection, and discouraging tanning in young adults. This project addresses the critical need for efficacious skin cancer preventive interventions for young adults in the college setting.

PI_NAMEs: HAY, JENNIFER L;WU, YELENA PING (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: adaptive intervention;Address;Affect;aged;Appearance;Behavior;Behavioral;cancer prevention;Cancer Prevention Intervention;cancer risk;clinically significant;college;Communication;cost;Counseling;demographics;design;Development;Effectiveness of Interventions;Elements;Enrollment;expectation;Experimental Designs;experimental study;Feedback;follow-up;Future;Genetic Risk;genetic testing;genetic variant;Goals;Habits;improved;improved outcome;Incidence;Individual;innovation;Intervention;intervention effect;Intervention Studies;Lead;Life;Malignant Neoplasms;Measures;Mediating;Mediator;Melanoma;Metastatic Melanoma;Methods;Modeling;Monitor;multidisciplinary;multiphase optimization strategy;novel;novel therapeutics;Outcome;personalized intervention;Persons;Photography;Population;post intervention;prevent;Prevention;preventive intervention;Recommendation;Research;Research Design;Risk;Risk Behaviors;Risk Reduction;Seasons;sex;Skin Cancer;skin cancer prevention;Skin Carcinoma;skin damage;Skin tanning;sociodemographics;Subgroup;sun protection;Sunburn;Test Result;Testing;therapy development;Time;Treatment Efficacy;ultraviolet;university student;Utah;UV Radiation Exposure;Variant;Visual;Work;young adult

PROJECT_TITLE: Optimization of a personalized skin cancer risk intervention for at-risk young adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-A(02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Evidence suggests banning menthol flavor in cigarettes would have a positive benefit on public health. However, it is currently unknown how such a ban might be impacted by the availability of menthol flavor in e- cigarettes, an alternative tobacco product that people might switch to from cigarettes. The current project will study the impact of menthol flavor bans in cigarettes and e-cigarettes to inform tobacco policy to protect public health.

PI_NAMEs: BOLD, KRYSTEN W. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Adherence;Adult;Area;authority;Behavior;Black Populations;Black race;Cigarette;cigarette smoke;cigarette smoking;Clinical Research;combustible cigarette;Country;Electronic cigarette;electronic cigarette use;Exposure to;follow-up;Health;health disparity;health equity promotion;improved;Individual;interest;manufacture;Marketing;Menthol;Modeling;Motivation;Nicotine Dependence;non-cigarette tobacco product;Outcome;outcome prediction;Participant;Persons;Policies;Population;primary outcome;Public Health;public policy on tobacco;Race;racial difference;Randomized;recruit;Regulation;Research;Sales;secondary outcome;simulation;Smoke;Smoker;Smoking;Smoking Behavior;smoking cessation;Surveys;Testing;Time;Tobacco;tobacco control;tobacco flavor;tobacco products;Tobacco use;Vulnerable Populations;Work

PROJECT_TITLE: Evaluating the potential impact of a menthol ban in cigarettes and e-cigarettes among current menthol smokers


PI_NAMEs: WEISS, MARGARET  (contact)

PROJECT_TERMS: 17 year old;Abuse Reporting;acceptability and feasibility;access disparities;Accounting;age group;aged;behavioral health;Clinic;Cognitive;college;Communities;compare effectiveness;Complex;Computers;coping;coping mechanism;Counseling;COVID-19;Data;Databases;Diagnosis;Disadvantaged;Disparity;disparity reduction;Distress;E-learning;Early identification;Early Intervention;early screening;Early treatment;Education;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Electronic Health Record;Electronics;Ethnic Origin;Explosion;Face;Family;feasibility testing;follow-up;Food;functional improvement;functional status;Future;Haitian;Health Alliance;Health Promotion;Health Services;Health Services Accessibility;Health system;help-seeking behavior;high risk;Individual;Institute of Medicine (U.S.);Insurance;Intervention;Language;Measurement;Measures;Mental disorders;Mental Health;mental health personnel;Methods;Minority;minority children;minority communities;Neighborhoods;novel;Outcome;outreach;Paper;Parents;peer support;perceived discrimination;Population;Portuguese;prevent;Prevention;Preventive;preventive intervention;promote resilience;Race;reduce symptoms;remediation;Reporting;resilience;Risk;Risk Factors;Sampling;school closure;School-Age Population;Schools;screening;Self Efficacy;single episode major depressive disorder;Social Distance;social health determinants;social stigma;socioeconomics;Spanish;stressor;Structure;Students;Substance abuse problem;substance use;Symptoms;Technology;Teenagers;Testing;Therapeutic Intervention;Time;tool;Trauma;treatment disparity;Unemployment;Work;Youth

PROJECT_TITLE: Prevention and Early Identification for High Risk Youth in School-based Clinics


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Antibiotic resistance especially in the ESKAPE pathogens represents a significant public health crisis. Elucidation of the role of extracellular heme metabolism and its integration into the virulence networks of P. aeruginosa will aid in identifying novel therapeutic strategies at the interface of iron homeostasis and virulence.

PI_NAMEs: OGLESBY, AMANDA GAIL;WILKS, ANGELA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;Aerobic;Affect;Anti-Bacterial Agents;Antibiotic Resistance;antimicrobial;antimicrobial resistant pathogen;antitermination;Bacterial Infections;Binding;Binding Proteins;Biochemical;biochemical tools;Biological Process;biophysical techniques;biophysical tools;Biophysics;Cells;Cessation of life;chronic infection;Citric Acid Cycle;constitutive expression;Cytoplasm;Data;DNA;DNA biosynthesis;Drug resistance;EMSA;enteric pathogen;ESKAPE pathogens;Event;extracellular;Fluorescence Anisotropy;Future;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic study;Genetic Transcription;Goals;Heme;heme-binding protein;Homeostasis;Homologous Gene;human pathogen;in vivo;Infection;innovation;Iron;Klebsiella pneumoniae;Laboratories;Life;Link;Membrane;Metabolism;Methods;Microbial Biofilms;microbial homeostasis;Micronutrients;microorganism;Molecular;mRNA Transcript Degradation;Mutation;Mycoses;new therapeutic target;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Oxygenases;pathogen;pathogenic bacteria;pathogenic microbe;Peptide Hydrolases;Post-Transcriptional Regulation;posttranscriptional;promoter;Property;Proteins;Proteomics;Pseudomonas aeruginosa;Public Health;receptor;Regulation;Regulon;Reporting;Respiration;rho;RNA;RNA Binding;RNA chemical synthesis;Role;Shigella dysenteriae;Siderophores;Signal Transduction;Site-Directed Mutagenesis;System;Testing;Time;Toxin;trait;transcription regulatory network;Transcriptional Regulation;Up-Regulation;uptake;Uropathogenic E. coli;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Integration of heme acquisition and signaling in Gram-negative pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Due to relentlessly evolving drug resistance, a continual pipeline of new drug discovery is required to combat mortality caused by the malaria parasite. We have identified three new chemical series based on phenotypic screening and will conduct a medicinal chemistry and target identification program to determine if they have the potential to be developed for the treatment of malaria. Our multidisciplinary team has extensive experience working together and a successful track record in identifying drug candidates.

PI_NAMEs: PHILLIPS, MARGARET A. (contact);READY, JOSEPH M

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: absorption;acquired drug resistance;ADME Study;African;Ames Assay;Amides;analog;Anti-malarials;Antiparasitic Agents;azetidine;Biochemical;Biological;Biological Assay;Biology;Blood;Cell Line;Cells;Cessation of life;Chemicals;Chemistry;Chemoprevention;Child;Clinical;clinical candidate;clinical development;combat;Communicable Diseases;comparative efficacy;crosslink;Data;Development;Disease;Dose;drug candidate;drug discovery;Drug Kinetics;Drug resistance;drug-sensitive;Erythrocytes;Evaluation;Excretory function;experience;Genetic;genome sequencing;Goals;Half-Life;HepG2;high throughput screening;Human;Human Cell Line;human disease;In Vitro;in vivo;Insecticides;insight;Ion Channel;Kinetics;Lead;lead optimization;Life Cycle Stages;Liver;Malaria;Mammalian Cell;Mass Spectrum Analysis;Measures;Medicine;Metabolic;Metabolism;Modeling;Molecular Target;mortality;mouse model;multidisciplinary;Mus;novel;novel therapeutics;Parasite resistance;Parasites;Parents;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;piperidine;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Population;Positioning Attribute;pre-clinical;preclinical development;pressure;Process;programs;Property;Proteomics;Protocols documentation;Publishing;Rattus;Recrudescences;Resistance;Risk;Safety;safety assessment;scaffold;SCID Mice;screening;Series;small molecule libraries;Solubility;Structure;Testing;Tetrazoles;Time;transmission blocking;Vaccines;Validation;whole genome;Work

PROJECT_TITLE: Optimization of novel phenotypic screening hits for treatment of Malaria

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Biotechnology;Transplantation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Blockade of CD154 is a highly effective method of inducing transplantation tolerance (a state in which transplant recipients would no longer require toxic immunosuppression), however clinical translation of CD154 blockers has met with many challenges, and as an alternative reagents that block CD40 (the receptor for CD154) are now in the clinical pipeline. However, CD40 blockers are not as effective as CD154 blockers, and here we have identified a novel molecular interaction that explains this discrepancy. Mechanistic understanding of this new molecular interaction is of the utmost importance in order to devise innovative strategies to block these residual interactions and thus optimize the use of CD40 blockers in the clinic.

PI_NAMEs: FORD, MANDY L (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Address;Adhesions;Affinity;allograft rejection;Allografting;Alternative Therapies;antagonist;Anti-CD40;Antibodies;Binding;Binding Sites;Biological;Biological Assay;Blood Platelets;CD8-Positive T-Lymphocytes;cell motility;Chemotactic Factors;Clinic;Clinical;clinical development;Clinical Research;clinical translation;clinically relevant;Communication;crosslink;Data;early phase clinical trial;Event;Experimental Models;experimental study;FOXP3 gene;Frequencies;Generations;Hemostatic Agents;Human;Immunosuppression;in vivo;Infiltration;Inflammation;innovation;isoimmunity;ITGAM gene;Leukocytes;Mediating;Mediator;Methods;migration;Modeling;Monoclonal Antibodies;monocyte;Mus;Myeloid Cells;Nature;nonhuman primate;novel;Outcome;Paper;Pathway interactions;Peptides;Phase;pre-clinical;preclinical study;prevent;Primates;Reagent;receptor;Reporting;Residual state;Role;Safety;Signal Transduction;Solid;Source;Surface Plasmon Resonance;T cell infiltration;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Thromboembolism;TNFRSF5 gene;TNFSF5 gene;trafficking;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: CD11b:  A Novel Alternate Receptor for CD154 during Alloimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(02)M]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE  Chromatin-bound regulators are aberrantly activated in cancer cells to promote transcriptional programs important for driving tumor initiation and progression. However, despite identification of oncogenic regulators in multiple tumor types, a gap in this rapidly evolving field is the definition of how those regulators mechanistically operate, which is required to identify interaction surfaces that can be used to target them in cancer. In both the F99 and K00 phases of this award, I will elucidate the underlying molecular mechanisms by which chromatin- bound regulators sustain oncogenic transcriptional programs, and define critical surfaces required for hallmarks of cancer, thereby allowing me to devise novel therapeutic vulnerabilities in cancer.

PI_NAMEs: HYDER, USMAN  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;APC gene;arm;Automobile Driving;Award;beta catenin;Binding;Biological Assay;biophysical properties;cancer cell;Cancer Etiology;cancer initiation;Cancer Patient;Cell Proliferation;Cells;Chromatin;Clinic;colon cancer patients;Colorectal Cancer;Complex;Cryoelectron Microscopy;Data;Fusion Oncogene Proteins;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genetic Transformation;genomic locus;Genomics;Goals;Histone H2A;Human;inhibitor;Invaded;Knowledge;Lead;lead candidate;loss of function;loss of function mutation;Malignant Neoplasms;member;Modeling;Molecular;mortality;Mutate;Mutation;novel;novel strategies;novel therapeutics;Nucleosomes;Oncogenic;Oncoproteins;Patients;Phase;Phenotype;Postdoctoral Fellow;programs;Proliferating;promoter;Proteins;Publications;Publishing;Reader;recruit;Repression;Research;Research Project Grants;response;Role;Running;scaffold;Site;small molecule inhibitor;soft tissue;Structure;Surface;synovial sarcoma;Testing;Therapeutic;therapeutic target;Training;transcription factor;Transcriptional Activation;tumor;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;Up-Regulation;WNT Signaling Pathway;Work

PROJECT_TITLE: Exploiting Oncogenic Chromatin Regulators in Cancer Initiation and Progression


ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Engineered T cells programmed to recognize and kill tumors have emerged as an extraordinarily powerful tool for combating cancer. Nonetheless, aside from chimeric antigen receptor T cells for the treatment of blood cancers, most engineered cell therapies are often ineffective and potentially highly toxic, particularly those that target solid tumors. This research proposal develops synthetic biology tools to combat three major challenges of engineered T cells: tumor recognition, toxicity and the immunosuppressive tumor microenvironment.

PI_NAMEs: ABDELFATTAH, NOURAN SAIED (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adverse event;Affect;Affinity;Amino Acids;Animal Model;Antigen Targeting;Antigens;Autoantigens;autoreactive T cell;Award;B lymphoid malignancy;Binding;Biochemistry;Bypass;Cancer cell line;cancer immunotherapy;Cancer Model;cancer therapy;cancer/testis antigen;CAR T cell therapy;CD8-Positive T-Lymphocytes;cell killing;Cell Therapy;cellular engineering;Cessation of life;chimeric antigen receptor T cells;clinical efficacy;Clinical Trials;Collection;combat;Complex;Coupled;cross reactivity;Cytomegalovirus;design;Development;Directed Molecular Evolution;engineered T cells;Engineering;Ensure;Epitopes;exhaustion;experience;Face;FDA approved;gene therapy;Generations;Genetic;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;high throughput screening;HLA Antigens;Human Genome;Immune signaling;Immune system;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;Infiltration;insight;interest;Learning;Libraries;Ligands;Logic;Malignant Neoplasms;Methods;Modification;Molecular Biology;mouse model;neoplastic cell;novel;novel strategies;novel therapeutics;Peptides;Phage Display;Phase;Population;Postdoctoral Fellow;programs;Proliferating;Protein Engineering;Proteins;receptor;Research;Research Project Grants;Research Proposals;Residual state;response;Scanning;screening;Signal Transduction;Solid Neoplasm;Specificity;Statistical Data Interpretation;success;Surface Antigens;synthetic biology;systemic toxicity;T cell infiltration;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Immunologic Specificity;T-Cell Proliferation;T-Cell Receptor;T-Cell Receptor Genes;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;Toxic effect;Training;tumor;Tumor Antigens;tumor microenvironment;tumor specificity;tumor-immune system interactions;Viral;virome;Work;Yeasts

PROJECT_TITLE: Cellular engineering to improve the efficacy and specificity of targeted immunotherapy