NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Emergency Care;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Serious Mental Illness;Substance Misuse;Suicide;Suicide Prevention;Telehealth;Underage Drinking

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Emerging adults have higher rates of binge drinking, thoughts of suicide, and suicide attempts than any other age group, but very low use of substance use treatment. This project seeks to develop a mobile health intervention guided by an avatar for emerging adults who visit the emergency department and who binge drink and experience thoughts of suicide. Because emerging adults prefer mobile health and self-guided interventions and such technology is widely accessible, the proposed mobile health intervention could offer significant public health benefit in reducing alcohol use disorders and suicidal thoughts in emerging adults.

PI_NAMEs: KELLY, LOURAH MARIE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;active control;Address;Adolescent;Adult;Age;age group;Aggressive behavior;alcohol comorbidity;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol services;alcohol use disorder;Alcoholic Intoxication;Alcohols;Ambulatory Care;Appearance;Area;Attenuated;Award;Behavior monitoring;binge drinking;career;career development;Caring;chronic alcohol ingestion;Clinical;Collaborations;comorbidity;Consultations;Consumer Participation;Data;Depressed mood;design;Development;Development Plans;diaries;drinking;Ecological momentary assessment;Education;Educational workshop;efficacy trial;Emergency Care;Emergency department visit;emerging adult;Evaluation;experience;feasibility research;feasibility testing;Feedback;Feeling hopeless;Feeling suicidal;follow-up;Foundations;Future;Goals;group intervention;hands on research;Health Benefit;high risk population;ideation;Individual;informant;Intervention;Interview;iterative design;Link;medical specialties;Mental Health;Mentors;Methods;mHealth;mhealth interventions;Mobile Health Application;Moods;multidisciplinary;novel;Outpatients;Patients;Persons;Phase;pilot trial;Population;Postdoctoral Fellow;programs;Protocols documentation;Provider;Public Health;Randomized;Randomized, Controlled Trials;Reading;reduced alcohol use;Reporting;Research;Research Personnel;Risk;Risk Factors;Safety;safety testing;Self-Injurious Behavior;Services;Severities;Signal Transduction;skills;substance use;substance use treatment;suicidal;Suicide;Suicide attempt;Suicide prevention;System;Technology;technology intervention;Testing;therapy development;Time;Training;trial comparing;unnecessary treatment;usability;Voice;young adult;Youth

PROJECT_TITLE: Development and Evaluation of an Avatar Guided Mobile Health for Emerging Adults

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Human papillomavirus (HPV) related oropharyngeal cancer (OPC) is increasing in incidence globally, and is disproportionately higher among people living with HIV (PLWH). Unlike cervical and anal cancers caused by HPV, no screening tests are available for OPC. Therefore, in this application we propose to study oral HPV natural history among PLWH to obtain data urgently needed to inform the development of future prevention/early detection strategies.

PI_NAMEs: GIULIANO, ANNA R. (contact)

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Aberrant DNA Methylation;Age;age acceleration;Aging;Alcohols;Americas;Anatomy;Area;Behavioral;biological age;Biological Aging;Biological Markers;biomarker identification;Cancer Etiology;cancer risk;carcinogenesis;CD4 Lymphocyte Count;Chronic;Clinical;Clinical Data;co-infection;Collaborations;Country;Data;Dental Care;Dental Hygiene;Development;disorder risk;Early Diagnosis;efficacy evaluation;epigenetic marker;Exclusion;follow-up;Funding;Future;Goals;Grant;high risk;HIV;HIV therapy;HPV oropharyngeal cancer;HPV screening;Human Herpesvirus 4;human old age (65+);Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Human papillomavirus 16;Immune;Immune System Diseases;Incidence;Infection;Inflammation;Infrastructure;Integration Host Factors;Knowledge;Latin America;Latin American;Literature;Location;male;malignant mouth neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;men;Methods;Methylation;modifiable risk;multidisciplinary;Natural History;Nested Case-Control Study;novel;Oncogenic;Oral;Oral health;oral HPV;oral HPV infection;oral infection;Patients;Periodontal Diseases;Persons;Policies;Population;Predictive Factor;premalignant;prevent;Prevention;Prevention strategy;Primary Prevention;programs;Prospective Studies;Recording of previous events;Reproducibility;Research;Risk;Risk Factors;screening;Secondary Lesion;Secondary Prevention;Services;Sex Behavior;social factors;Specimen;Testing;Tobacco use;Tooth Loss;Tumor Suppressor Genes;Vaccination;Vaccines;Viral;Visit;Woman

PROJECT_TITLE: Oral HPV Research Among Latin Americans Living with HIV (ORAL - H² Study)


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Studies from the recent Zaire Ebola virus (EBOV) outbreaks in both Guinea and the Democratic Republic of the Congo (DRC) suggest that the FDA-approved EBOV vaccine can be highly effective. However, emerging data reveal EBOV vaccine failure rates as high as 30% in the DRC, a region of the world where malaria is endemic. Here, we use experimental malaria and Ebola virus infection systems to elucidate the mechanisms by which malaria alters the efficacy of Ebola virus vaccination.

PI_NAMEs: BUTLER, NOAH SULLIVAN;MAURY, WENDY JEAN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Address;Affect;Affinity;Africa;Antibodies;Antibody Affinity;Antibody Response;Antibody titer measurement;Antigens;Area;Attenuated;B-Lymphocytes;base;Blood;Case Fatality Rates;CD4 Positive T Lymphocytes;Cellular Immunity;clinical application;clinically relevant;Data;Death Rate;Democratic Republic of the Congo;design;Development;Disease Outbreaks;Dose;Ebola Vaccines;Ebola virus;Emergency Situation;Event;Failure;Family;FDA approved;Filovirus;Geography;Glycoproteins;Goals;Guinea;Helper-Inducer T-Lymphocyte;Human;Humoral Immunities;Immune;Immunization;Immunize;immunogenicity;Immunoglobulin Class Switching;Immunoglobulin G;Impairment;in vivo;Infection;Knowledge;Malaria;member;Memory;Memory B-Lymphocyte;Mus;novel strategies;Participant;Pathogenicity;Plasma Cells;Plasmodium;Plasmodium falciparum;Population;Porosity;protective efficacy;Public Health;Recombinant Vaccines;Resolution;response;Structure of germinal center of lymph node;System;T cell response;T-Lymphocyte Subsets;Testing;Time;transmission process;Vaccination;vaccination protocol;vaccination strategy;vaccine delivery;vaccine efficacy;vaccine failure;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine-induced immunity;Vaccines;Viral;Viral Hemorrhagic Fevers;Virulent;Virus;Virus Diseases;Zaire Ebola virus

PROJECT_TITLE: Defining the effect of Plasmodium infection on Ebola virus vaccine efficacy

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: NARRATIVE Disconnection and physiological dysfunction of interconnected association regions of the cerebral cortex that regulate cognitive functions is thought to be a primary pathology in multiple neurodevelopmental disorders, including schizophrenia and autistic spectrum disorder. This project will determine whether the neurons that interconnect association cortices—layer 2/3 projection neurons—are the target of NDD pathology due to oxidative stress caused by dysfunctional mitochondria. The data will define potential targets for novel therapies to ameliorate mitochondria-related circuit dysfunction and behavioral deficits in a broad range of NDDs.

PI_NAMEs: LAMANTIA, ANTHONY S (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 22q11;Adult;Animals;Antioxidants;Anxiety;association cortex;autism spectrum disorder;axon growth;Behavior;behavior influence;Behavioral;Bioenergetics;Cells;Cerebral cortex;Clinical;Cognitive;cognitive function;Cytology;Data;Dendrites;Development;DiGeorge Syndrome;Dimensions;Disease;Embryo;Ensure;Equilibrium;experimental study;Foundations;Functional disorder;Genes;Genetic;genetic association;Genetic Models;Genetic Recombination;Genetic Transcription;Growth;Human;in vivo;Individual;individual variation;insight;Intervention;Life;Locomotion;Maintenance;Mediating;Metabolic;Metabolism;Mitochondria;Molecular;Molecular Profiling;molecular site;mouse model;Mus;Neurodevelopmental Disorder;neuronal circuitry;Neuronal Differentiation;neuronal growth;Neurons;new therapeutic target;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Performance;pharmacologic;Phase;Physiological;postnatal;postsynaptic;preservation;presynaptic;Property;Prosencephalon;Proteomics;Reactive Oxygen Species;Regulation;Risk;Role;Schizophrenia;sensory gating;Site;Social Behavior;Social Interaction;spatial memory;Specificity;Synapses;synaptogenesis;Testing;Therapeutic;transcriptomics;Work

PROJECT_TITLE: Regulation of 22q11 Genes in Embryonic and Adult Forebrain

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Public Health Relevance. Diagnosis, staging, and treatment assessment of pancreatic cancer is severely challenged by the difficulty to delineate and reproducibly measure pancreatic lesions as a result of low-enhancement from contrast agents. We propose to develop high-sensitivity, low-bias spectral CT technology to enhance low concentration iodine visualization and mitigate system-dependent variability to allow quantitative image biomarkers as additional in- dicators for diagnosis and treatment efficacy. The technology developed in this work can be widely applied to improve quantitative accuracy of spectral CT applications, and facilitate robust clinical translation of novel spec- tral biomarkers for general disease management.

PI_NAMEs: GANG, JIANAN GRACE;NOËL, PETER B (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3D Print;Achievement;Algorithms;Anatomy;artificial intelligence algorithm;attenuation;Automobile Driving;Biological Markers;Biological Products;Calibration;Characteristics;Clinical;clinical application;clinical decision-making;clinical translation;Clinical Trials;Complement;Complex;Computed Tomography Scanners;Computer software;contrast enhanced;Contrast Media;Data;denoising;Dependence;design;Detection;detector;Diagnosis;Diagnostic;Disease;Disease Management;Enhancing Lesion;Evaluation;fluorodeoxyglucose positron emission tomography;Functional Imaging;Goals;Hybrids;Image;imaging approach;imaging biomarker;imaging modality;imaging system;Imaging Techniques;improved;Iodine;Joints;Lead;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Measurement;Measures;Methods;Modeling;Morphology;next generation;Noise;novel;novel therapeutics;Oncology;Organ;Outcome;Pancreas;Patients;Pattern;Performance;Perfusion;perfusion imaging;Physics;predictive modeling;Property;Protocols documentation;public health relevance;quantitative imaging;Radiation Dose Unit;Radiation exposure;Reproducibility;response;Roentgen Rays;Shapes;Source;Specific qualifier value;spectrograph;Staging;structural imaging;System;Technology;technology development;Texture;Theoretical model;Tissues;Treatment Efficacy;tumor;tumor microenvironment;Vendor;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Patient-specific, high-sensitivity spectral CT for assessment of pancreatic cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Hematology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Finding novel therapies for treatment of radiation-induced toxicities is of value to not only patients who are receiving radiotherapy for different conditions, but also to national security due to risk of terrorism attacks. This proposal will use exosomes, from stimulated mesenchymal stromal cells, to develop radioprotective monocytes as a new and innovative cellular therapy for acute radiation syndrome. Using highly innovative modes of in vivo cell tracking and detailed analyses of the mechanism by which these cells stimulate hematopoiesis, we will provide insight into how these cells protect against radiation; efficacy of the radioprotective monocytes will also be validated in 2 different animal models of radiation injury, and success of any of the aims will be a major advance in using cellular therapies for treating radiation injury.

PI_NAMEs: CAPITINI, CHRISTIAN  (contact);HEMATTI, PEIMAN

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Allogeneic Bone Marrow Transplantation;Allogenic;Anemia;Animal Model;Biomanufacturing;Blood;Blood Cells;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;CD34 gene;Cell Communication;Cell Survival;Cell Therapy;Cells;clinical practice;Coculture Techniques;Collaborations;CXCR4 gene;cytokine;Cytoprotection;Development;DNA;Engineering;Excretory function;exosome;Exposure to;Flow Cytometry;Generations;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Hemorrhage;high risk;Histopathology;Hour;Human;humanized mouse;Immune;Immunodeficient Mouse;improved;in vivo;Individual;Infection;Infusion procedures;innovation;insight;interest;Interleukin-6;Label;Life;Lipopolysaccharides;Macrophage;Magnetic Resonance Imaging;manufacture;Mediating;Medical;Membrane;Mesenchymal Stem Cells;mesenchymal stromal cell;MicroRNAs;mimetics;Modeling;monocyte;mortality risk;mouse model;Mus;National Security;Neonatal;novel therapeutics;Organ;Patients;Population;Pre-Clinical Model;Procedures;Production;Published Comment;Radiation;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;Radiation Protection;Radiation therapy;Radiation Tolerance;Radiation Toxicity;radioprotected;Reagent;Recovery;Risk;RNA;Role;Signal Transduction;stem cell exosomes;stem cell proliferation;success;System;Terrorism;Testing;therapy development;Thymus Gland;TLR4 gene;Toxic effect;trafficking;Translations;Vesicle;Whole-Body Irradiation

PROJECT_TITLE: Exosome educated monocytes for acute radiation syndrome

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative The reduction of bioinactive N2 by nitrogenase enzyme metalloccofactors is a foundational process for human life, resulting in the production of bioavailable N-sources to be used in the development of proteins, nucleic acids, and other cell constituents. To this end, the mechanism of the biological reduction of N2 remains largely unknown. The work proposed herein involves the synthetic design and reactivity of new low-valent tri-iron clusters which will act as biomimetic models for the metallocofactors of nitrogenase, providing an abiological route toward the elucidation of nature’s N2 fixation process.

PI_NAMEs: LATENDRESSE, TREVOR  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acetylene;Active Sites;Affect;Alkanes;Amines;analog;Architecture;Atmosphere;Binding;Biological;Biological Availability;Biological Models;biological systems;Biology;Biomimetics;Cells;Chemicals;Chemistry;cofactor;Complex;design;Development;Electrolyses;Electron Spin Resonance Spectroscopy;electronic structure;Elements;Enzymes;Event;Face;functional mimics;Generations;Goals;Human;Ions;Iron;Life;Ligands;Magnetometries;Mediating;Mediation;metal complex;Methods;Modeling;Molecular;Molecular Structure;Monitor;Mononuclear;Nature;Nitrogen;Nitrogenase;Nuclear;Nucleic Acids;Oxidants;Oxidation-Reduction;Oxides;Periodicity;Process;Production;Program Description;Property;Proteins;Protons;Reaction;Reagent;Reducing Agents;Research;Role;role model;Route;sample fixation;scaffold;Site;small molecule;Source;Spectrum Analysis;Structure;Study models;Sulfides;System;Testing;Transition Elements;Work;X ray diffraction analysis

PROJECT_TITLE: Multi-nuclear Iron Clusters as Biomimics of Nitrogenase Enzyme Metallocofactors


ADMINISTERING_IC: DE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Sexually Transmitted Infections;Tobacco;Tobacco Smoke and Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Infection with HIV increases susceptibility to oncogenic oral HPV infections that are associated with oral and oropharyngeal cancers. The proposed study will investigate the natural history of oral HPV in persons living with HIV (PLWH) participating in the largest HIV cohort study in the United States and will assess the effects of oral bacterial infections (microbiome) and fungal infections (mycobiome) on the risk of oral HPV persistence, an intermediate biomarker of HPV-associated cancers. This study should lead to innovative approaches to reduce the risks of HPV-associated oral and oropharyngeal cancers in PLWH.

PI_NAMEs: BURK, ROBERT D (contact);DIAZ, PATRICIA ;SCHLECHT, NICOLAS

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Actinomyces;Activities of Daily Living;Address;Affect;Alcohol consumption;antiretroviral therapy;Bacteria;Bacterial Infections;Biological Assay;Biological Markers;cancer risk;Candida;CD4 Lymphocyte Count;cohort;Cohort Studies;Communities;Coupling;Cutaneous;cytokine;Data;Dental;Detection;Disease;Enrollment;Ethnic Origin;Etiology;Evaluation;Exhibits;Female;Frequencies;fungus;Genes;Head and Neck Cancer;high risk;HIV;HIV Infections;HPV screening;HPV-High Risk;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune;Immune response;Immune system;Immunity;Incidence;Individual;Infection;Inflammation;innovation;Lesion;Longitudinal Studies;Malassezia;male;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;marijuana use;Measures;Mediation;metagenomic sequencing;Metagenomics;Methods;microbial;microbiome;Morbidity - disease rate;Mouth Diseases;mycobiome;Mycoses;Natural History;neoplastic;next generation sequencing;novel;Oncogenic;Oral;Oral cavity;Oral Characters;Oral health;oral HPV;oral HPV infection;oral lesion;oral microbiome;oral wart;Organism;Outcome;Papilloma;Participant;Pathway interactions;Patients;Persons;population based;Porphyromonas;Predisposition;Prevalence;Prevotella;Protein Analysis;Public Health;Race;Research Design;response;Ribosomal RNA;Risk;Risk Factors;RNA;Saliva;saliva sample;Sampling;Sex Behavior;Shotguns;Smoking;Smoking Behavior;Smoking History;Specimen;Structure;Taxonomy;therapy adherence;therapy duration;Time;Tobacco smoking behavior;Tooth structure;United States;Variant;Viral Load result;virome;Virulence Factors;Work;Xerostomia

PROJECT_TITLE: Impact of HIV, oral microbiome and mycobiome on oral HPV persistence


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The majority of interacting egg and sperm proteins involved in fertilization remain undetermined in humans. The proposed research combines state-of-the-art genomic, proteomic, and structural methods to characterize the interactions of egg and sperm proteins in abalone – a classic animal model of fertilization – as well as identify the effects of potential drivers of infertility in humans. The research will address general questions in reproductive biology, and may provide foundational knowledge towards the design of novel infertility treatments.

PI_NAMEs: WILBURN, DAMIEN BEAU (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: abalone;Address;Affinity;analog;Animal Model;Animals;Binding;Biochemical;Biochemistry;Biological Process;Capsid Proteins;Cell membrane;Code;Complex;design;Disparate;egg;Egg Proteins;Evolution;experimental study;Fertility;Fertilization;Fertilizers;Genes;Genome;Genomics;Germ Cells;Glycoproteins;Human;Hydrogen Bonding;Incidence;Individual;Infertility;infertility treatment;innovation;insight;Knowledge;lysin;Male Infertility;Mammals;marine;Mediating;men;Methods;Modeling;Molecular;Molecular Evolution;Multidimensional NMR Techniques;Mutagenesis;Mutation;mutation screening;new therapeutic target;novel;Oocytes;Organism;Pathway interactions;Phase;Pheromone;polymerization;Polymers;Process;protein expression;protein protein interaction;protein structure;Proteins;Proteome;Proteomics;receptor;Reproduction;reproductive;Reproductive Biology;Research;Sampling;sex;Shapes;Site;sperm cell;sperm protein;Sperm-Ovum Interactions;Structure;Structure-Activity Relationship;Study models;System;Techniques;Technology;Testing;three dimensional structure;Training;transcriptomics;ZP2

PROJECT_TITLE: Integrating 'omics', evolution, and biochemistry to understand fertilization


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Although research has produced overwhelming evidence that sexual minority women (SMW) are at substantially higher risk than heterosexual women of hazardous drinking and alcohol use disorders at least partially because of their exposure to minority stress, no studies have tested interventions aimed at reducing this disparity. In the proposed study we will test a remotely delivered transdiagnostic cognitive-behavioral intervention, EQuIP (Empowering Queer Identities in Psychotherapy), to improve minority stress coping and reduce SMW’s hazardous drinking and mental health comorbidities. If successful, this intervention can be implemented in SMW-serving community settings to help reduce hazardous drinking and its negative health consequences that disproportionately affect this at-risk population.

PI_NAMEs: HUGHES, TONDA L;PACHANKIS, JOHN EDWARD (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Affect;Affective;Alcohol consumption;Alcohol dependence;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;Anxiety;assault;Awareness;Back;Behavior Therapy;Behavioral;behavioral health;biological adaptation to stress;Bisexual;Cardiovascular Diseases;Cities;Cognitive;Cognitive Therapy;Communities;community center;community clinic;community setting;comorbid depression;comorbidity;coping;Coping Behavior;Counseling;County;Demographic Factors;Diagnostic;Discrimination;disparities in women;disparity reduction;drinking;efficacy testing;Eligibility Determination;emotion dysregulation;empowerment;Ethnic Origin;expectation;experience;Exposure to;Family;Foundations;Funding;Gender Identity;gender minority group;General Population;hazardous drinking;Health;Health Services;Heavy Drinking;help-seeking behavior;Heterosexuals;high risk;high risk population;implementation facilitators;improved;Incentives;Individual;internalized stigma;Intervention;intervention delivery;Intervention Trial;Interview;Knowledge;laboratory experience;Laws;Leadership;Lesbian;Lesbian Gay Bisexual Transgender Queer;Link;Liver diseases;Malignant Neoplasms;Mediating;men;Mental Depression;Mental Health;Meta-Analysis;Methods;minority stress;minority stressor;Modality;Morbidity - disease rate;mortality;Motivation;National Institute on Alcohol Abuse and Alcoholism;Participant;Pathway interactions;peer;personalized medicine;Persons;pilot trial;Policies;Population;Populations at Risk;Preparation;primary outcome;Promoting Action on Research Implementation in Health Services framework;Protocols documentation;Provider;psychosocial;Psychotherapy;queer;Race;Randomized, Controlled Trials;Reaction;remote delivery;remote intervention;Reporting;Research;response;Risk;Role;scale up;secondary outcome;Services;Sex Orientation;sexual identity;sexual minority group;sexual minority women;Shame;Site;skills;social stigma;Stress and Coping;stress reduction;Structure;System;telehealth;Testing;Therapeutic Intervention;timeline;Training;treatment as usual;United States National Institutes of Health;Waiting Lists;Woman;Women's Health;World Health Organization

PROJECT_TITLE: A unified protocol to address sexual minority women's minority stress, mental health and hazardous drinking

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project narrative Aggregation of the microtubule-associated protein tau in the brain is one of the two hallmarks of Alzheimer’s disease. Determining how post-translational modifications of tau mediate the formation, propagation and spreading of tau neurofibrillary tangles is important for developing tau-specific compounds to diagnose and inhibit Alzheimer's disease. We propose to use solid- state NMR spectroscopy, electron microscopy and biochemical methods to elucidate the structures and dynamics of tau in the aggregated, membrane-bound and microtubule-bound states to elucidate the structural basis of Alzheimer's disease.

PI_NAMEs: HONG, MEI  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Adopted;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Axon;Binding;Biochemical;Biological Assay;Biomedical Research;Brain;C-terminal;Charge;Chemicals;cofactor;Complex;Cryoelectron Microscopy;Data;Democracy;Diagnosis;Disease;Dissociation;Drug Design;drug discovery;Electron Microscopy;Epitopes;experimental study;Filament;Future;Heparin;Human;In Vitro;in vitro Model;Joints;Label;Length;Light;MAPT gene;Measures;Mediating;Membrane;Membrane Lipids;Methods;microscopic imaging;Microtubules;mimetics;Modernization;Modification;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;monomer;Mus;mutant;Mutation;N-terminal;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxicity;NMR Spectroscopy;novel;paired helical filament;Pathologic;Pathology;phospho-L-arginine;Phosphorylation;Phosphorylation Site;Post-Translational Protein Processing;prion-like;Process;Proline-Rich Domain;Property;Proteins;Recombinants;reconstruction;Research;Shapes;Site;Societies;solid state;solid state nuclear magnetic resonance;Staging;Structure;Surface;Synaptic Membranes;tau aggregation;tau interaction;tau Proteins;tau-1;Tauopathies;Tertiary Protein Structure;Testing;Therapeutic Intervention;Toxic effect;unilamellar vesicle;Wild Type Mouse;Work

PROJECT_TITLE: Tau structure and dynamics in Alzheimer's disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Prevention;Social Determinants of Health

ORG_CITY: SAN BERNARDINO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

ORG_STATE: CA

PHR: NARRATIVE Magnified by population aging, researchers continue to search for ways to protect against cognitive decline or Alzheimer’s dementia in older ages. This study will determine to what extent particular social activities are associated with cognitive change, and how these associations differ by gender. Findings may lead to informed gender-specific activity recommendations and an eventual standardization of social participation measures in social surveys.

PI_NAMEs: VOGELSANG, ERIC  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Age;Aging;aging population;Alzheimer's Disease;American;Automobile Driving;Award;Cognition;Cognitive;cognitive change;cognitive function;Communities;daily functioning;Dementia;disorder risk;Education;Empirical Research;Exercise;experience;Family;Family member;Frequencies;Friends;Gender;gender disparity;Goals;Grant;Health;Health and Retirement Study;high risk drinking;Hispanic-serving Institution;human old age (65+);Impaired cognition;improved;Individual;Inequality;Life;Life Cycle Stages;Link;Living Arrangement;Longitudinal Studies;Measures;meetings;Mentors;Mentorship;Mexican;middle age;Motivation;older adult;Outcome;Patients;Play;Policy Maker;prevent;protective effect;psychologic;Publications;Recommendation;Recording of previous events;Religiosity;Research;Research Personnel;Risk Reduction;Role;sex disparity;social;social cognition;social engagement;social norm;Social Sciences;Social support;Socialization;Specificity;Standardization;Students;Surveys;Time;trend;undergraduate student;United States National Institutes of Health;Validity and Reliability;volunteer;Work

PROJECT_TITLE: Older Adult Social Participation, Gender, and Cognitive Decline


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: Newton

ORG_NAME: TISSUEVISION, INC.

PHR: PROJECT NARRATIVE This proposal describes a novel AD screening platform that combines spatial biology, whole brain imaging, automated histological processing, and advanced image analysis. It will be offered as a fee-for-service platform based on a high-performance cloud infrastructure that can serve, visualize, and analyze multiplexed terabyte datasets. This proposal will allow researchers to apply cutting-edge advances in the fields of spatial biology and deep learning to the latest AD research models, and thus better make informed, clinically translatable decisions that will further the development of AD therapies.

PI_NAMEs: RAGAN, TIMOTHY M. (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3-Dimensional;Affect;Age;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapy;analysis pipeline;Atlases;Automobile Driving;Back;base;Biological Sciences;Biology;Brain;Brain imaging;Brain Mapping;Brain region;brain research;cell type;Cells;Cellular biology;Client;Clinic;Clinical;clinical translation;cloud based;Cloud Computing;cloud platform;Collaborations;Communities;Complex;Consensus;cost;Cytometry;Data;Data Analyses;data management;Data Set;data visualization;deep learning;Development;dimension reduction;effective therapy;Ensure;Etiology;Fee-for-Service Plans;Fluorescence;Funding;high resolution imaging;Histologic;human old age (65+);Image;Image Analysis;Image Cytometry;imaging approach;Imaging technology;in vivo imaging;indexing;Indiana;instrument;instrumentation;interest;Investments;Label;Location;Manufacturer;Maps;Methods;Modeling;Molecular;mouse model;Multimodal Imaging;multiphoton imaging;multiple omics;Mus;nano-string;Nature;Nerve Degeneration;Neurosciences;next generation;novel;Organ;Output;Performance;Persons;Pharmacologic Substance;Phase;Proteins;Proteomics;Publications;Publishing;Refractory;Research;Research Contracts;Research Personnel;Resources;Sampling;Series;Services;sex;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;success;synergism;System;Techniques;Technology;terabyte;The Jackson Laboratory;Therapeutic Intervention;three-dimensional modeling;Tissue imaging;Tissues;tool;transcriptomics;treatment comparison;treatment effect;treatment group;two-photon;United States;United States Department of Veterans Affairs;Universities;Visualization

PROJECT_TITLE: A high throughput multiplexed pipeline for models of Alzheimer’s Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Adenovirus (Ad) vectors are one of the most frequently used vector systems in human clinical trials aimed at ameliorating genetic diseases and treating cancer. Despite many advantages of Ad vectors as potential therapeutics, the potent systemic inflammation that is triggered by intravascular administration of Ad remains a serious barrier to clinical applications. The molecular mechanisms underlying the exacerbation of systemic inflammation are poorly understood. This project is based on our recent discovery that human serum samples that lack Ad neutralizing antibodies are able to activate complement and trigger complement fixation on the virus, leading to a potentiated inflammatory response from human immune cells. We will comprehensively address the origin and function of non-neutralizing immunity to Ad and its role in compromising the safety of intravenous Ad administration.

PI_NAMEs: SHAYAKHMETOV, DMITRY  (contact);STEWART, PHOEBE L

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;adaptive immunity;Address;Adenovirus Vector;Adenoviruses;Animals;Anti-viral Response;Antibodies;Antigen-Antibody Complex;arm;Attenuated;base;Binding;Biological;Blood;Blood Coagulation Factor;Cancer Patient;cancer therapy;Cell Compartmentation;cell type;Cells;Cessation of life;Clinical;clinical application;clinical development;clinical practice;Clinical Trials;Coagulation Process;Complement;Complement Receptor;Complex;Cryo-electron tomography;cytokine;Defense Mechanisms;Development;Disseminated Malignant Neoplasm;Distant;Dose Limiting;Enrollment;Ensure;Exclusion;Exhibits;Fc Receptor;Funding;Gene Expression;Gene Transfer;Generations;Genetic Diseases;Hematopoietic stem cells;Hepatocyte;Hepatotoxicity;High Prevalence;Human;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunization;Immunoglobulin M;Immunologics;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Innate Immune Response;Innate Immune System;insight;Intervention;Intravenous;intravenous administration;Iron;Knowledge;Macrophage;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;Natural Immunity;neutralizing antibody;novel;novel strategies;oncolytic vector;patient stratification;Patients;Phagocytes;pharmacologic;Phylogenetic Analysis;Population;Prevalence;Production;Property;public health relevance;receptor;Research Personnel;response;Role;Safety;sample fixation;Sampling;Science;Serotyping;Serum;Signal Pathway;System;systemic inflammatory response;systemic toxicity;Therapeutic;therapeutic development;therapeutic gene;Therapeutic Intervention;tool;Toxic effect;vector;Viral;virtual delivery;Virus;Virus Inactivation

PROJECT_TITLE: Mechanisms of adenovirus neutralization

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: The proposed research is relevant to public health because it advances an innovative model of hypertension care - community health workers empowered by mobile health technology to identify and manage hypertension - which overcomes the health care workforce limitations not addressed by current approaches in low- and middle-income countries. This model would be widely adaptable to low-resource settings around the world, leading to increased identification and treatment of people with hypertension. Thus, the proposed research is relevant to the part of the Fogarty International Center’s vision that pertains to reducing the burden of disease, promoting health, and extending longevity for all people.

PI_NAMEs: DUFFY, SEAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: acute care;Address;Adult;Adverse event;Awareness;Blood Pressure;blood pressure control;burden of illness;Cardiovascular Diseases;Caring;Cause of Death;Cessation of life;Chronic;Chronic Disease;Clinic;Clinical;clinical decision support;Collaborations;Communities;Community Health Aides;Community Healthcare;cost effective;Counseling;Country;Development;diabetes management;Diabetes Mellitus;Diagnosis;diagnostic accuracy;disability;Disease;Disease Outcome;effectiveness evaluation;efficacy evaluation;empowerment;Enrollment;Event;Experimental Designs;Fogarty International Center;Goals;Government;Guatemala;health care delivery;Health Promotion;Health system;Health Technology;Healthcare;Hypertension;hypertension control;hypertension treatment;hypertensive;improved;Income;Infrastructure;innovation;Intervention;Intervention Trial;Life Style;Longevity;low and middle-income countries;Medical;mHealth;Mission;mobile application;Mobile Health Application;Modeling;Morbidity - disease rate;mortality;neighborhood safety;Nurses;Patient Education;Patient Participation;patient screening;Patients;Persons;Pharmaceutical Preparations;Physicians;Play;Preclinical Testing;Primary Care;primary outcome;Process;programs;Protocols documentation;Provider;Public Health;Randomized;Recommendation;Research;Resource-limited setting;Role;Rural;rural area;Safety;safety outcomes;screening;standard care;Supervision;Technology;Testing;Titrations;Training;Vision;Work

PROJECT_TITLE: mHealth to Enable Task Sharing for Hypertension Care in LMIC


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Hematology;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Rare Diseases;Sickle Cell Disease

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative The proposed research is of high public health relevance in Uganda and sub-Sahara Africa because infant screening for sickle cell disease (SCD) is a pillar to control childhood mortality due to this disease. A locally sustainable screening information management and communication system (SIMCS) is critical to achieve nationwide access to infant SCD screening. Therefore, this proposal is relevant to NIH mission to foster research innovations that improve health outcomes, health care services and health research including in low/middle income countries.

PI_NAMEs: LUBEGA, JOSEPH ;SEWANKAMBO, NELSON K (contact)

PROJECT_TERMS: Adolescence;Adopted;Adoption;Adult;Affect;Africa;African;Algorithms;Android;Biological Assay;care coordination;Caring;Cellular Phone;Cessation of life;Child;Childhood;Chronic;Cities;Clinical;clinical care;Cluster randomized trial;college;Communication;Communities;community based research;Community Participation;community research;Complex;Computer software;Continuity of Patient Care;cost;Counseling;Country;Custom;Data;data centers;data exchange;data management;Demographic and Health Surveys;design;Development;Diagnosis;digital;disability;Disease;disorder control;Early Diagnosis;Education;Erythrocytes;Evaluation;Event;evidence base;experience;Family;feasibility testing;Feedback;Fostering;Goals;Health;health care service;Health education;Health Sciences;Health system;Hemolytic Anemia;Hospital Referrals;hydroxyurea;improved;improved outcome;Income;Individual;Infant;Infant Care;Informatics;Information Management;Infrastructure;Inherited;innovation;Intervention;Level of Evidence;Logistics;low and middle-income countries;Maintenance;mHealth;Mission;Morbidity - disease rate;mortality;multidisciplinary;novel;Operating System;Organ;Outcome;Outcomes Research;Pain;Patient Education;Patients;Pediatric Hematology;Phase;point of care;Policies;Population;Prevention;primary care provider;primary health center;Process;Program Evaluation;programs;Provider;public health relevance;Reproducibility;Research;Research Infrastructure;Resources;Rural;Rural Community;Sahara;Sampling;scale up;screening;screening program;screening services;Sickle Cell;Sickle Cell Anemia;Site;smartphone application;Software Design;Specialist;Standardization;System;Test Result;Testing;Text Messaging;Time;transmission process;Transportation;Uganda;United States National Institutes of Health;Universities;Vaccination

PROJECT_TITLE: Development and Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening.


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE: These experiments are relevant to public health for two reasons. First, they may provide proof-of-concept data for testing an entirely new type of HIV vaccine that could protect against all strains of HIV, and second, that incorporating specific proteins into a vaccine may result in increased rather than decreased rates of transmission due to their pro-inflammatory effects. Here we propose the novel hypothesis that targeting key accessory genes using an innovative MHC-II invariant chain vaccine platform that enhances immune responses to non-dominant peptides, while avoiding responses to dominant peptides, should confer complete protection from HIV infection.

PI_NAMEs: VEAZEY, RONALD S. (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Acute;acute infection;Adenoviruses;Adjuvant;Affect;Animals;Antibodies;Antibody Response;Antigen Presentation;antigen-specific T cells;Antigens;antiretroviral therapy;breakthrough infection;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;chronic infection;Collaborations;Cross Presentation;Data;design;Dose;env Gene Products;Epitopes;exhaust;exhaustion;experimental study;Focal Infection;gag Gene Products;Genes;HIV;HIV Infections;HIV vaccine;Human;immune activation;Immune response;Immune system;Immunity;improved;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Response;innovation;International;invariant chain;Link;Macaca;Mediating;Mucous Membrane;Mutation;novel;novel vaccines;pathogenic virus;Pathogenicity;Peptides;prevent;Primate Retrovirus;Primates;Protein Isoforms;Proteins;Public Health;Publishing;recruit;Rectum;Research;response;Rodent;Serotyping;SIV;success;System;T-Cell Activation;Testing;transmission process;trial design;Universities;Vaccinated;Vaccination;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine efficacy;vaccine platform;vaccine response;Vaccinee;Vaccines;vaccinia virus vector;Variant;vector;Viral;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Vaccination with invariant MHC-II-linked accessory antigens for protection from HIV infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Genetics;Health Effects of Indoor Air Pollution;Lung;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Maternal smoking during pregnancy is the largest preventable cause of childhood respiratory illness, and children whose mothers smoked during pregnancy show lifetime decreases in airway function and increased respiratory illnesses and asthma. We have shown that vitamin C supplementation to pregnant smokers improves their offspring's airway function through 5 years of age. This project will continue to study these children through 10 years of age to demonstrate if this improvement in airway function persists, if the improvement is due to larger airways, and the potential epigenetic changes that could underlie these improvements.

PI_NAMEs: MCEVOY, CYNTHIA T (contact);MORRIS, CYNTHIA D;SPINDEL, ELIOT R;TEPPER, ROBERT S.

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 10 year old;5 year old;6 year old;Adoption;Adult;Adverse effects;Affect;Age;American;Antismoking;Area;Ascorbic Acid;Asthma;Blinded;Blood;Blood specimen;Child;Child Health;Childhood;Clinical;Clinical Investigator;cohort;Data;Development;Diameter;DNA Maintenance;DNA Methylation;Dose;Early Intervention;Epigenetic Process;epigenome;Exposure to;Fetal Lung;follow-up;Genes;Growth and Development function;Hair;Health Care Costs;High Resolution Computed Tomography;Impairment;improved;in utero;Infant;injured airway;Intervention;Length;Life;longitudinal analysis;Longitudinal Studies;lung development;Lung Diseases;maternal cigarette smoking;Maternal Exposure;Measurement;Measures;Mediating;Mediation;Molecular;Mothers;National Heart, Lung, and Blood Institute;Nicotine;offspring;Outcome;Participant;Pathway interactions;Placebos;postnatal;Pregnancy;prenatal;prenatal cigarette smoking;prenatal intervention;prevent;primary outcome;pulmonary function;Randomized;Randomized, Controlled Trials;Research Personnel;respiratory;respiratory health;respiratory morbidity;Risk;Risk Factors;Scanning;Smoke;Smoking;smoking during pregnancy;Supplementation;Swab;Testing;Time;Toxic Environmental Substances;Trees;Wheezing;Woman

PROJECT_TITLE: Vitamin C to Decrease Effects of Smoking during Pregnancy on Offspring Airway Function, Airway Size, and Epigenetic Correlates: VCSIP cohort follow-up through 10 Years of Age

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Burden of Illness;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: African Caribbeans have a one of the highest global rates of high blood pressures, which can lead to abnormalities in the heart muscle and its function. However, there is currently no information from the general population in this geographic region on the health of the heart muscle and its functioning in African Ancestry Caribbeans. Therefore, this study seeks to describe the current burden of abnormalities in heart muscle and its function in African Caribbeans from Tobago and to determine the most important risk factors for these abnormalities, including assessment of culturally unique factors like diet, physical activity, body fat distribution, and circulating factors in the blood.

PI_NAMEs: KUIPERS, ALLISON L;MILJKOVIC, IVA  (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: African;African American;African American population;African ancestry;African Caribbean;aged;archive data;Behavior;Biological Assay;Biological Markers;Biological Process;Biology;Blood;Blood Pressure;blood pressure elevation;Blood Vessels;Body fat;Cardiac;Cardiac health;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Caribbean region;Clinical Research;cohort;comorbidity;Cost Analysis;Creatinine;Data;demographics;Demography;design;Diet;Echocardiography;EFRAC;Endothelin-1;Epidemiology;epidemiology study;Family;Fibrosis;Fostering;Functional disorder;Funding;Future;General Population;Geographic Locations;Health;Heart;Heart Abnormalities;Heart Atrium;Heart Diseases;Heart failure;high risk;high risk population;Hypertension;hypertensive;IL6 gene;Immigrant;improved;indexing;Inflammation;Injury to Kidney;insight;Left;Left Ventricular Hypertrophy;Left Ventricular Mass;Life Style;Measures;Medical History;men;molecular marker;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;myocardial injury;Myocardium;Neurosecretory Systems;novel;Obesity;Participant;Phenotype;Physical activity;Physiologic pulse;Population;population based;Population Study;post gamma-globulins;Prevalence;Prevention;pro-brain natriuretic peptide (1-76);Publishing;Recording of previous events;Research;response;Risk;Risk Factors;Smoking;Stretching;Structural defect;Structure;Tobago;ultrasound;Vascular Diseases;Woman;Women's study

PROJECT_TITLE: Epidemiology of Cardiac Structure and Function in African Caribbeans: The Tobago Heart Study

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Kidney Disease;Racial and Ethnic Minority Health Research;Sepsis

PHR: African Americans are 20% more likely to die of sepsis compared to people of European descent, even after adjusting for co-variates. Close to 45% African American carry at least one APOL1 risk allele, which has shown to be associated with increased incidence and severity of sepsis.

PI_NAMEs: SUSZTAK, KATALIN  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Adhesions;Adult;Affect;African American;African American population;African Trypanosomiasis;Albuminuria;American;Apolipoproteins;Autophagocytosis;biobank;Blood Coagulation Disorders;cecal ligation puncture;Cell Adhesion Molecules;cell type;Cells;Coagulation Process;Code;cohort;cytokine;Defect;Development;Disease;disorder risk;Endocytosis;Endothelial Cells;Endothelium;epigenome;European;Extravasation;First Independent Research Support and Transition Awards;Functional disorder;Gene Expression;Genes;Genetic;Genetic Models;genetic selection;Genotype;glomerulosclerosis;Glycocalyx;health determinants;health disparity;Hepatocyte;high risk;hospitalization rates;Hospitals;Human;In Situ Hybridization;in vivo;Incidence;inducible gene expression;Inflammasome;Inflammation;Inflammatory;Interferons;Kidney;kidney cell;Kidney Diseases;Link;Lipopolysaccharides;Mitochondrial DNA;Modeling;Molecular;mortality;mouse model;Mus;novel therapeutics;Nucleotides;Organ;Parasites;Pathology;Pathway interactions;Patients;Permeability;Persons;pharmacologic;Plasma;podocyte;Predisposition;Resistance;Risk;risk variant;Role;Sepsis;Severities;Study models;trafficking;transcriptome;Transgenic Mice;Trypanosoma;Variant;Vascular Permeabilities;Virus Diseases

PROJECT_TITLE: APOL1 associated disease spectrum

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Physical Activity;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end- stage kidney disease. A stepwise combination of lifestyle modifications and drug therapy is recommended to lower blood pressure; however, adherence to time-intensive lifestyle interventions such as aerobic exercise in patients with chronic kidney disease is poor. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure and improving endothelial function in midlife and older adults with moderate-to-severe chronic kidney disease and inadequately controlled hypertension, and to use innovate translational assessments to understand the mechanisms involved.

PI_NAMEs: CHONCHOL, MICHEL BENJAMIN (contact);NOWAK, KRISTEN LYNN

PROJECT_TERMS: Adherence;Adult;Aerobic Exercise;Antioxidants;Arginine;Biological Availability;Biomedical Research;Biopsy;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure reduction;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell Culture Techniques;Chronic Kidney Failure;circulating biomarkers;Clinical;Clinical Trials;clinically relevant;dehydroascorbate;design;Double-Blind Method;Dropout;End stage renal failure;Endothelial Cells;Endothelium;Epidemic;Functional Magnetic Resonance Imaging;Funding;Glomerular Filtration Rate;Guidelines;handheld equipment;high risk;Hour;Human;Hypertension;improved;Individual;Inhalation;innovation;insight;interest;Intervention Trial;Kidney Diseases;Life Style Modification;lifestyle intervention;Link;Magnetic Resonance Imaging;Measures;Mediating;metabolomics;middle age;modifiable risk;molecular marker;mortality;muscle strength;Nitric Oxide;NOS3 gene;novel;novel therapeutics;older adult;older men;older women;Oxidative Stress;Oxidative Stress Induction;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pilot trial;Plasma;pressure;primary outcome;Process;Production;Protocols documentation;Public Health;Randomized;Reactive Oxygen Species;Recommendation;Regimen;Regulation;Renal Blood Flow;Research Priority;Resistance;Rest;Role;Safety;secondary outcome;Serum;Signal Transduction;strength training;Time;Training;treatment duration;Umbilical vein;Vascular Diseases;vascular endothelial dysfunction

PROJECT_TITLE: Inspiratory muscle strength training for lowering systolic blood pressure in midlife and older adults with chronic kidney disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Ventricular tachyarrhythmias often underlie hemodynamic collapse and sudden death. While ablation can suppress recurrent ventricular tachyarrhythmias, efficacy is limited and major complications, including exacerbation of heart failure. Here we explore a complementary strategy: rather than destroying heart tissue, we seek to modify the substrate using anti-fibrotic exosomes secreted by cardiosphere-derived cells (CDCs).

PI_NAMEs: DAWKINS, JAMES F. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Animal Model;Antiinflammatory Effect;Area;Arrhythmia;Biological;Biological Assay;Blood Pressure;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiomyopathies;Catheters;Cell Cycle;cell type;Cells;Chronic;Cicatrix;Clinic;Clinical;clinical translation;Coculture Techniques;comparative efficacy;coronary vasculature;Data;Electric Stimulation;Evaluation;exosome;extracellular vesicles;Fibroblasts;Fibrosis;first-in-human;Fostering;Frequencies;Gadolinium;Genetic Transcription;Goals;Heart;Heart failure;heart function;hemodynamics;Histologic;Human;Implant;improved;in silico;In Vitro;in vivo;Infarction;inhibitor;Injections;Ion Channel;ischemic cardiomyopathy;Longterm Follow-up;Magnetic Resonance Imaging;Malignant - descriptor;Maps;Measurement;Methods;Modeling;Modification;Myocardial;myocardial injury;Myocardium;nanovesicle;Parents;Pathway interactions;Patients;Perfusion;Peripheral;Physiologic Monitoring;Pirfenidone;porcine model;pre-clinical;Predisposition;prevent;Prevention;Procedures;Proliferating;Property;Protein Analysis;Radiofrequency Interstitial Ablation;reconstruction;recruit;Recurrence;recurrence prevention;regenerative;Rodent;Route;Safety;safety assessment;stem cells;Stromal Cells;sudden cardiac death;Sudden Death;systemic inflammatory response;Tachyarrhythmias;Techniques;Telemetry;Testing;Tissue Viability;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Translating;Validation;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Biological substrate modification to suppress ventricular arrhythmias in a porcine model of chronic ischemic cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Only 3% of older adults in the US have proficient health literacy, even less have proficient eHealth literacy, and this is worse for Spanish-preferred older adult Latinos, who are a largely underserved population in the US. eHealth literacy is necessary for engaging in eHealth, which has the potential to improve health outcomes for older adults and is becoming increasingly necessary due to the ubiquity of technology in health as part of living in the post- COVID era. Prior eHealth literacy interventions typically focused on English-language participants, which is important, but the pandemic highlighted health inequities in the use of technology for healthcare that can be addressed by the proposed research on the development, implementation, and evaluation of culturally and linguistically appropriate eHealth interventions that increase eHealth literacy for older adult Spanish preferred Latinos in the US.

PI_NAMEs: VAZQUEZ, CHRISTIAN E (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: acceptability and feasibility;Address;Aging;Area;Award;career;career development;Communication;Communities;community advisory board;community based research;community partnership;Country;COVID-19;COVID-19 pandemic;culturally appropriate intervention;Data;Development;Development Plans;digital;Disparity;Distance Learning;Doctor of Philosophy;Educational Intervention;effective intervention;efficacy evaluation;eHealth;electronic health information;Emotions;English Language;Environment;ethnic disparity;ethnic minority;Ethnic Population;Evaluation;evidence base;experience;Family;Feasibility Studies;Focus Groups;Foundations;Funding;Future;Goals;Grant;Health;Health behavior and outcomes;health care availability;Health Disparities Research;health disparity;health inequalities;health literacy;Health Promotion;Health Technology;Home;human old age (65+);implementation science;improved;innovation;Institution;Insurance Coverage;Intervention;Knowledge;Language;Latino;Latino Population;Learning;Learning Module;Length;Linguistics;literacy;Literature;Measures;member;Mentored Research Scientist Development Award;Mentors;Methods;novel;older adult;Online Systems;Outcome;pandemic disease;Participant;Pattern;peer;poor health outcome;Positioning Attribute;post intervention;post-COVID-19;Postdoctoral Fellow;Practice based research;professor;Public Health Informatics;Qualifying;Race;racial minority;racial population;recruit;Religion;Religious Belief;remote delivery;Research;Research Personnel;Resources;Review Literature;Sample Size;Sampling;Schools;Social Work;socioeconomics;Source;Spanish;Surveys;Target Populations;Technology;technology intervention;Texas;therapy development;Time;Training;Translating;Treatment Efficacy;Underrepresented Populations;Underserved Population;Universities;Work

PROJECT_TITLE: Spanish Language Older Adult eHealth Learning

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: Rickettsioses are diseases caused by bacterial pathogens belonging to the genus Rickettsia. Pathogenic Rickettsia are typically transmitted to humans by blood-feeding arthropods (insects and ticks). This project seeks to examine the interplay between Rickettsia felis and the vector fleas, to better understand the epidemiology of an emerging flea-borne rickettsiosis.

PI_NAMEs: MACALUSO, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;Antigens;Area;Arthropod Vectors;Arthropods;Asia;Biological;Biological Assay;Biology;Blood;California;Characteristics;co-infection;comparative;Complex;Culicidae;Data;Disease;Disease Management;Disease Outbreaks;Ecosystem;Environment;Epidemiology;Europe;experience;Experimental Designs;experimental study;feeding;Felis catus;Fever;flea-borne;Fleas;Funding;Genes;Genome;Genotype;Genus Felis;Goals;Health;Horizontal Disease Transmission;Human;human pathogen;Immune;Immune response;Infection;innovation;Insecta;Intervention;Investigation;Knowledge;Mechanics;Mediating;member;Modeling;Molecular;North America;novel;novel strategies;Oceania;Organism;pathogen;pathogenic bacteria;Pathogenicity;Population;prevent;Publishing;Recording of previous events;Regulation;Reporting;Reproducibility;Research;Resources;response;Rickettsia;Rickettsia felis;Rickettsia Infections;Rickettsia typhi;Role;Salivary;Skin;South America;spotted fever;suburb;System;Techniques;Testing;Texas;Ticks;transmission process;Typhus;United States;vector;vector competence;vector transmission;Vector-transmitted infectious disease

PROJECT_TITLE: Emerging Flea-Borne Rickettsial Diseases: vector competence and transmission biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative  Depression is the leading cause of disability worldwide with a lifetime prevalence of ~17% in the United States, with one third of cases developing treatment-resistant depression. Noninvasive neurostimulation therapies such as repetitive Transcranial Magnetic Stimulation (rTMS)–where a magnetic coil placed over the cortex is used to focally stimulate the brain–have recently emerged as promising low-risk interventions for treatment-resistant depression, but it is unclear why they work incredibly well for some patients and not at all for others. We propose a bold new approach to personalization of rTMS treatment that uses generative neural networks to learn and then simulate possible treatment response trajectories for depressed patients in order to improve personalization and better understand the mechanisms of accelerated neurostimulation treatments.

PI_NAMEs: GROSENICK, LOGAN  (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Aftercare;American;Biological;Biological Markers;biotypes;Brain;Chronic stress;Clinical;Clinical Trials;cohort;COVID-19 pandemic;Data;density;Depressed mood;depressed patient;Development;digital twin;disability;Disease remission;Disproportionately impacts women;Effectiveness;Electroencephalography;Functional Magnetic Resonance Imaging;generative adversarial network;Hour;Human;improved;in silico;Individual;Individual Differences;individual response;individualized medicine;innovation;insight;Intervention;Learning;Life;Literature;machine learning framework;Magnetism;Major Depressive Disorder;Measurable;Measurement;Measures;Mental Depression;Modality;Modeling;neural network;Neurobiology;neurophysiology;novel strategies;outcome prediction;Patients;Pattern;personalized medicine;Persons;pharmacologic;physical model;Prediction of Response to Therapy;Prevalence;Protocols documentation;psychologic;repetitive transcranial magnetic stimulation;Research;Rest;Risk;simulation;Social isolation;socioeconomic disadvantage;Symptoms;synthetic data;Techniques;Training;Trauma;Treatment Protocols;treatment response;treatment-resistant depression;trend;United States;Work

PROJECT_TITLE: Scalable Biomarkers and Generative Digital Twins for Personalized Neurostimulation in Depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public Health Relevance Statement (Project Narrative) The Caltech/UCLA individualized Theranostic Engineering to Advance Metabolic System (Caltech/UCLA iTEAM) is distinct in applying a humanistic approach to integrate training in imaging or sensing coupled with computing to address cardiometabolic disease. The Caltech/UCLA iTEAM is synergistic to provide structured training in research, teaching, recruitment, and retention to enhance diversity and inclusion for our engineering and physical science scholars. In comparison with other comparable bioengineering T32 programs, the added value of Caltech/UCLA iTEAM is our joint mentorship with the biomedical faculty and our partnership with the industry leaders, thus, providing a nurturing ecosystem to inspire, enrich, and empower the under-represented groups to pursue leadership careers in academia or industry.

PI_NAMEs: DI CARLO, DINO ;EMAMI, AZITA ;HSIAI, TZUNG K (contact);TAI, YU-CHONG

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Caltech/UCLA Individualized Theranostic Engineering to Advance Metabolic System (iTEAM)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE CB1 are cannabinoid receptors that signal through canonical second messenger pathways (cAMP inhibition) as well as -arrestin. The goal of this proposal is to examine a new major pathway activated by CB1 and to identify ligands targeting this new signaling mechanism. The results of the project will increase the current knowledge of cannabinoids signaling.

PI_NAMEs: BRAILOIU, EUGEN  (contact);WARD, SARA J

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Agonist;Amino Acid Motifs;Amino Acids;Analgesics;antinociception;Arrestins;Behavioral;beta-arrestin;Binding;Biological Assay;Body Temperature;C-terminal;C57BL/6 Mouse;Cannabinoids;Catalepsy;Cells;Choline;CNR1 gene;Complex;Consensus;Couples;Cues;Cyclic AMP;Cyclic GMP;Data;Development;drug development;Experimental Designs;experimental study;extracellular;Female;FRAP1 gene;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genomics;Goals;GTP Binding;Guanine Nucleotide Exchange Factors;Hydrophobicity;Image;in vivo;inhibitor;interdisciplinary approach;Investigation;Knowledge;Ligands;male;Measurement;Measures;Mediating;Molecular;Monomeric GTP-Binding Proteins;Motor Activity;mutant;Mutate;Mutation;Neurons;Pathway interactions;Pertussis Toxin;pharmacologic;Pharmacology;Phosphatidic Acid;Phospholipase D;Physiology;Protein C;Proteins;receptor;Receptor Activation;Receptor Mediated Signal Transduction;Receptor Signaling;response;rho;rho GTP-Binding Proteins;Role;Second Messenger Systems;Sequence Alignment;sex;Signal Induction;Signal Pathway;Signal Transduction;Solid;Specificity;Stimulus;Structural Protein;Tail;Tertiary Protein Structure;Testing;therapeutic development;transcription factor;Transfection;Work

PROJECT_TITLE: Deciphering the complex pharmacology of CB1: towards the understanding of a third signaling pathway

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Diffuse Intrinsic Pontine Gliomas (DIPG) are incurable pediatric high grade brain tumors. This disease is characterized by highly recurrent lysine-to-methionine mutation on the histone H3 genes (H3K27M) that causes alteration in chromatin regulation. The goal of this project is to understand the H3K27M induced chromatin alteration that lead to DIPG in order to formulate a molecular informed therapeutic strategy.

PI_NAMEs: PIUNTI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 6 year old;Acetylation;Acute;Address;Affect;Affinity;Amino Acids;Animals;Automobile Driving;Binding;Biochemical;Biochemistry;Biological Assay;Brain Neoplasms;Brain Stem;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cell Proliferation;Cell Separation;Cells;Characteristics;Chemosensitization;Child;Childhood;Childhood Brain Stem Neoplasm;Childhood Central Nervous System Neoplasm;Childhood Solid Neoplasm;Chromatin;Clinical;clinically relevant;Combined Modality Therapy;Complex;CRISPR screen;Data;Deposition;Diagnosis;Diffuse;Diffuse intrinsic pontine glioma;Disease;Disease Progression;efficacious treatment;Epigenetic Process;epigenome;Event;Exclusion;experimental study;Gene Expression;Gene Expression Profile;Gene Silencing;Generations;Genes;Genetic;Genetic Engineering;Genetic Transcription;genome-wide;Glioma;Goals;H3 K27M mutation;Heterozygote;Histone H3;Histones;improved;In Vitro;in vivo;Incidence;inhibitor therapy;insight;Knowledge;Lysine;Maintenance;Measures;Mediating;Mentors;Methionine;Methylation;Modeling;Molecular;Molecular Biology;mortality;mouse model;Mus;mutant;Mutation;neoplastic cell;Nucleosomes;Oncogenic;Outcome;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phase;Phase I Clinical Trials;Point Mutation;Polycomb;Pontine structure;Positioning Attribute;pre-clinical;Property;Protein Isoforms;Proteins;Radiation therapy;Reaction;recruit;Recurrence;Regulation;Resistance;resistance mechanism;Role;Sampling;Site;small molecule inhibitor;standard of care;System;Therapeutic;Tissues;Treatment Protocols;tumor;tumor growth;tumorigenesis;Universities;Work;Xenograft procedure

PROJECT_TITLE: A molecular informed therapy for Diffuse Intrinsic Pontine Gliomas (DIPG)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Sleep Research

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Delayed Sleep-Wake Phase Disorder is a Circadian Rhythm disorder that affects millions of people each year representing an important public health issue. This project will utilize rigorous circadian approaches to systematically test novel hypotheses of the pathophysiological mechanisms of DSWPD. We anticipate our findings will be the first step in establishing novel and effective treatment approaches for DSWPD.

PI_NAMEs: WRIGHT, KENNETH P (contact);ZEE, PHYLLIS C.

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Age;American;analog;Biological Factors;Biological Markers;Blood specimen;Body Temperature;Chronotherapy;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythm Disorder;Circadian Rhythms;Clinical Practice Guideline;Clinical Trials;Cognitive;comparison control;Data;design;Development;Disease;Distal;Drowsiness;Eating;effective therapy;Etiology;falls;Functional disorder;Glucose;Goals;Guidelines;Health;Human;improved;life span;Light;light effects;Literature;maladaptive behavior;Melatonin;member;Meta-Analysis;Modeling;National Heart, Lung, and Blood Institute;novel;novel marker;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Peripheral;Personal Satisfaction;Persons;Phase;Physiological;Precision Medicine Initiative;primary outcome;Probability;Protocols documentation;Public Health;Research;response;Sampling;Schedule;Schools;Science;secondary outcome;sex;Skin Temperature;Sleep;Sleep Deprivation;sleep health;social;Strategic vision;Temperature;Testing;Time;Translating;treatment strategy;United States National Institutes of Health;vigilance;Visual;Work

PROJECT_TITLE: Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PI_NAMEs: SLINGERLAND, JOYCE MARIE (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Adult;adult stem cell;Binding;Binding Sites;Biological Assay;Bone Marrow Stem Cell Transplantation;Breast Epithelial Cells;c-myc Genes;C-terminal;cancer stem cell;CCNE1 gene;CDK2 gene;CDK4 gene;Cell Adhesion;Cell Cycle;Cell Cycle Arrest;Cell Differentiation process;cell motility;Cell Proliferation;cell type;Cells;ChIP-seq;Chromatin;Compensation;Complex;Consensus;Cyclin D1;Cyclins;Data;Defect;Development;Differentiation and Growth;Disease;Embryoid bodies;Euchromatin;Exhibits;falls;Gene Expression;gene repression;Genes;Genetic Transcription;genomic profiling;Gigantism;Grant;Growth;Hematology;Hematopoietic;Heterochromatin;human disease;Hyperplasia;in vivo;induced pluripotent stem cell;inhibitor;insight;Knock-out;Mediating;mimetics;Modeling;mouse development;Mus;mutant;Mutation;Natural regeneration;new therapeutic target;Normal Cell;Normal tissue morphology;novel;Organ;Periodicity;Phase Transition;Phenotype;Phosphorylation;PIK3CG gene;Play;progenitor;programs;promoter;Proteins;Proto-Oncogene Proteins c-akt;recruit;regeneration function;Regenerative Medicine;Repression;Repressor Proteins;restraint;Role;S phase;Signal Transduction;Site;STAT3 gene;stem;stem cell expansion;stem cell population;stem cell self renewal;stem cells;Testing;TGFB2 gene;Therapeutic;Tissue Differentiation;tissue regeneration;tissue stem cells;Tissues;Trans-Activators;transcription factor;Transforming Growth Factor Beta 2;Transgenes;Transgenic Mice;tumor initiation;Work

PROJECT_TITLE: Novel roles for p27 as transcriptional co-regulator of cJun in stem cells and development

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This ambitious experimental and theoretical collaboration will investigate how internal states (such as task engagement) influence decision-making, and identify the underlying neural mechanisms. The proposed work will produce an integrated, circuit-level model that explains decision behavior and neural activity in healthy and autism model mice, which show a reduced ability to make decisions that take changing expectations into account. Decision-making is also impaired in addiction and schizophrenia, so a deeper understanding of brainwide decision-making circuitry may contribute to future research on ways to treat or mitigate these disorders.

PI_NAMEs: CHURCHLAND, ANNE KATHRYN;PANINSKI, LIAM M (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: addiction;Affect;Anatomy;Animals;Area;Axon;Bar Codes;Behavior;Behavioral;Biological Assay;Brain;Brain region;cell type;Collaborations;Collection;Communication;Computer Models;Computing Methodologies;Data Analyses;Data Collection;data infrastructure;data management;Data Science Core;Data Set;data sharing;Decision Making;deep learning;Development;Disease;Environment;Etiology;expectation;experimental study;flexibility;Food;Gene Expression;Genetic;Goals;Histology;Impairment;Individual;Infrastructure;International;Laboratories;large datasets;large scale data;Learning;Maps;Measurement;Measures;Methods;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;Mutation;neural;neural circuit;neuromechanism;Neurons;next generation;novel;open source tool;optogenetics;Pattern;Population;Productivity;Protocols documentation;Reproducibility;Research;Research Personnel;Rewards;Schizophrenia;Standardization;Structure;Testing;theories;tool;Training;Ultrasonography;Wild Type Mouse;Work

PROJECT_TITLE: State-dependent Decision-making in Brainwide Neural Circuits


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: PANINSKI, LIAM M (contact)

PROJECT_TERMS: Arbitration;Behavior;Brain;Collaborations;Collection;Communication;Communities;computational neuroscience;conflict resolution;cost;data access;data dissemination;data portal;Data Science;data sharing;Decision Making;Ensure;experience;Faculty;Feedback;Fostering;Genomics;Goals;Group Meetings;Infrastructure;Institution;International;Knowledge;Laboratories;Leadership;Learning;Maintenance;member;Methods;Monitor;neural;neural circuit;neurophysiology;Neurosciences;Neurosciences Research;open data;optical imaging;outreach;Participant;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Progress Reports;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Development;Resources;Running;Scientist;statistics;Structure;Students;Techniques;Time;tool;United States National Institutes of Health;Universities;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

PHR: RELEVANCE (See instructions): Asymmetric cell division is a vital aspect of both regular human cell progression (e.g. embryonic development, tissue homeostasis) and disease states (e.g. cancer). However, quantitative studies of asymmetric cell division are stymied by the difficulty of systematically perturbing native cell differentiation pathways. This research will use a novel synthetic biology approach to develop experimental and mathematical models for studying asymmetric cell division in multicellular systems.

PI_NAMEs: BENNETT, MATTHEW R. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Agar;Bacteria;Behavior;behavior prediction;biological systems;Biology;biophysical model;Biophysics;Birth;cell behavior;Cell Communication;Cell Differentiation process;Cell division;cell growth;cell motility;cell type;Cell-Cell Adhesion;Cells;Cellular Structures;Collaborations;Complex;Computer Models;Computing Methodologies;Data;design;Development;Devices;Differential Equation;Differentiation and Growth;Disease;Disparate;Dysplasia;Embryonic Development;Engineering;Environment;Escherichia coli;Event;experience;Experimental Models;experimental study;Gene Expression;Genetic;Goals;Growth;healing;Homeostasis;Human;Instruction;intercellular communication;Lead;Length;Life;Link;Liquid substance;malformation;Malignant Neoplasms;mathematical methods;mathematical model;Mathematics;Mechanics;member;microbial;Microbial Biofilms;Modeling;Molecular;molecular scale;novel;Organism;Parameter Estimation;Pathway interactions;Pattern;Pattern Formation;phenomenological models;Phenotype;Population;Population Control;Population Dynamics;predictive modeling;Process;promoter;Property;Protein Engineering;Publishing;Regulation;Regulatory Pathway;Research;response;self organization;Signal Transduction;Signaling Molecule;spatiotemporal;stem cells;Study models;synthetic biology;Synthetic Genes;System;Techniques;tissue regeneration;Tissues;tool;tumor;Work

PROJECT_TITLE: Dynamics and pattern formation in differentiating cellular populations


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PROJECT_TERMS: Algorithmic Analysis;Algorithms;Architecture;Area;Behavior;Behavioral;Brain;Calcium;Cells;Collaborations;Communication;Communities;computational neuroscience;Data;Data Analyses;data exchange;data management;data pipeline;Data Science;Data Science Core;data science resource;Data Set;data standards;data tools;Decision Making;Development;experimental study;Genomics;Goals;Histology;Image;improved;in situ sequencing;Infrastructure;International;International Aspects;Laboratories;laboratory development;Learning;Maps;Metadata;method development;Methods;Modeling;neural;neural circuit;Neurons;neurophysiology;Neurosciences;Occupational activity of managing finances;open data;open source;open source tool;optical imaging;optogenetics;platform as a service;Process;Reproducibility;Research Personnel;Resources;Services;Sorting;statistics;Task Performances;Testing;theories;tool;Ultrasonography;Work

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Rheumatologic disorders are an increasing cause of morbidity and mortality due both to a rising incidence of autoimmunity and to our aging population. The training of physician-scientists who specialize in investigation is essential for scientific discovery and for devising better strategies for treatment and disease prevention. The goal of this program is to educate the next generation of such individuals by providing qualified candidates with advanced training in research methodology and effective mentorship so they develop into our future leaders in investigative rheumatology.

PI_NAMEs: BUCALA, RICHARD J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Rheumatology;Training Programs

PROJECT_TITLE: Training Program in Investigative Rheumatology


PI_NAMEs: MRSIC-FLOGEL, THOMAS  (contact)

PROJECT_TERMS: Anatomy;Area;Atlases;Behavior;Behavioral;Brain;Brain region;brain tissue;Calcium;cell type;Cells;Collaborations;Collection;Communication;Communities;Computer software;computerized data processing;Data;data acquisition;Data Analyses;Data Collection;data handling;Data Science Core;Data Set;Decision Making;Development;diverse data;Electrophysiology (science);experimental study;Fiber;Goals;Histologic;Histological Labelings;Histology;Image;Image Analysis;International;Label;Laboratories;Learning;Light;Methodology;Methods;Modeling;Mus;Nervous System;neural;neural circuit;Occupational activity of managing finances;open source;optical fiber;Optics;optogenetics;Outcome;Output;Pathway interactions;Photometry;Population;Procedures;Process;Protocols documentation;reconstruction;Reproducibility;Research Personnel;Sampling;Scientist;Services;Site;software development;Software Tools;Standardization;Structure;Task Performances;Techniques;Testing;Theoretical model;theories;Tissues;tool;two-photon;Ultrasonography;Update;Work;working group

PROJECT_TITLE: Histology Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative The project is relevant to public health because it accelerates the development of phage-based tools for the rapid detection of bacterial pathogens in human, food, and environmental samples, and the treatment of diseases from multidrug resistant bacteria by integrating machine learning and synthetic biology. Thus, it is specifically relevant to part of NIH's mission that pertains to the diagnosis, prevention, and cure of human diseases.

PI_NAMEs: NUGEN, SAM R (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Acceleration;Acinetobacter baumannii;Address;Alkynes;Amino Acid Sequence;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;arms race;Azides;Bacteria;Bacterial Genome;Bacterial Infections;Bacteriophage T4;Bacteriophages;Binding;Binding Proteins;Biosensing Techniques;Biosensor;Capsid;Chemistry;Clinical;Computer Models;Consumption;CRISPR/Cas technology;Custom;Data;Data Set;design;Detection;Development;Diagnosis;Disease;Drug resistance;Elements;Engineering;Enterobacteriaceae;Environment;Escherichia coli;Evolution;Family;Fiber;Food;Future;Genes;Genome;Goals;Health;Human;human disease;Infection;Innate Immune Response;Innate Immune System;innovation;Intervention;Life;Literature;Machine Learning;Magnetic nanoparticles;Magnetism;Methods;Mission;Modeling;Modification;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;Natural Immunity;next generation;novel;Outcome;pathogen;pathogenic bacteria;Patients;Persons;Phenotype;Polyethylene Glycols;Prevention;Process;Property;Public Health;rapid detection;receptor;Reporting;Research;Research Personnel;Resistance;resistance mechanism;Sampling;screening;Site;Specificity;Surface;synthetic biology;System;Tail;Technology;Therapeutic;Therapeutic Agents;therapeutically effective;Time;tool;training data;United States National Institutes of Health;unnatural amino acids;Viral;Virus

PROJECT_TITLE: Accelerating phage evolution and tools via synthetic biology and machine learning

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Angiogenesis, the process of new blood vessel formation from preexisting capillaries, is associated with the pathogenesis of a number of eye diseases including retinopathy of prematurity (ROP). Understanding how exposure of premature infants to high oxygen levels, to help with their lung development and function, interferes with normal development of retinal vasculature and causes retinal neovascularization is critical for the development of effective treatments to save vision in these patients.

PI_NAMEs: ZAITOUN, ISMAIL S (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adverse effects;Affect;angiogenesis;Apoptosis;Apoptotic;Astrocytes;BCL2 gene;Blood capillaries;blood vessel development;Blood Vessels;Cardiovascular system;Cell Death;Cells;Clinical;Complex;Development;Disease;effective therapy;Embryonic Development;Endothelial Cells;Exposure to;Eye diseases;Family member;Germ Lines;Goals;Homeostasis;Hyperoxia;Induced Neurons;Induction of Apoptosis;insight;Ischemia;Knowledge;lung development;macroglia;Mediating;member;Microglia;Modeling;Molecular;mouse model;Mus;Myeloid Cells;neovascularization;Nerve Degeneration;Nerve Growth Factors;Neural Retina;Neuroglia;neuron apoptosis;neuron development;Neuronal Dysfunction;Neurons;novel therapeutics;Oxygen;Pathogenesis;Pathway interactions;Patients;Pericytes;Play;pre-clinical;Pre-Clinical Model;Premature Infant;prevent;Process;Protein Family;Publishing;pulmonary function;Regulation;Respiratory Insufficiency;response;Retina;retina blood vessel structure;retinal angiogenesis;retinal apoptosis;Retinal Diseases;Retinal Neovascularization;retinal neuron;Retinopathy of Prematurity;Role;Source;Testing;Time;unpublished works;vascular contributions;Vascular Endothelial Growth Factors;Vision;Work

PROJECT_TITLE: Neural Retina-Specific Bim Expression and Hyperoxia Sensitivity of the Developing Retinal Vasculature

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: Dover

ORG_NAME: FORTISCIENCE, INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE Current treatment approaches that are designed to prevent atherosclerosis progression by reducing LDL cholesterol levels often fail to prevent the growth and evolution of atherosclerotic plaques in patients’ arteries. Fortiscience, Inc. is taking a novel approach to treating atherosclerosis by developing a drug that inhibits fortilin, a key protein involved in the survival of macrophages, which contribute to plaque formation and inflammation. This novel drug, which is intended to prevent plaque progression, will provide an alternative to lipid-lowering therapies and reduce the risk of life-threatening cardiovascular events in patients with atherosclerosis.

PI_NAMEs: FUJISE, KEN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Affect;Affinity;American;Animals;Apoptosis;appropriate dose;Arterial Fatty Streak;Arteries;Atherosclerosis;Binding;Biological Assay;Biological Availability;C57BL/6 Mouse;Cardiovascular Diseases;Cardiovascular system;Cell Death;Cell Physiology;Cells;Cholesterol;Clinical Trials;Collaborations;computational chemistry;cytokine;cytotoxicity;Data;design;Development;diet and exercise;Dissociation;Docking;Dose;Drug Kinetics;drug-like compound;Event;Evolution;Exhibits;experience;first-in-human;Foam Cells;Future;Goals;Growth;Half-Life;Health;hypercholesterolemia;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;Intervention;knock-down;knockout gene;Laboratories;LDL Cholesterol Lipoproteins;Lead;Legal patent;Life;lifestyle intervention;Lipids;Liver Microsomes;Macrophage;Measures;medication safety;Metabolic;Methods;Modification;Molecular Weight;mouse model;Mus;Muscle;Myocardial Infarction;nanomolar;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Oral;Oral Administration;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;preclinical development;preclinical study;prevent;Prevention;Principal Investigator;programs;Proliferating;Proteins;Recurrence;Research;Research Contracts;Risk Factors;Risk Reduction;Role;screening;Secondary Prevention;side effect;Small Business Technology Transfer Research;small molecule inhibitor;smoking cessation;Stroke;Structure;Structure-Activity Relationship;Symptoms;Testing;Therapeutic;therapeutic target;timeline;Tissues;Toxic effect;Toxicokinetics;TPT1 gene;United States National Institutes of Health;Universities;virtual;Washington;Work

PROJECT_TITLE: Development of a Small Molecule Inhibitor of Fortilin for Atherosclerosis Treatment and Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IVBH-V(10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: PILLOW, JONATHAN WILLIAM (contact)

PROJECT_TERMS: 3-Dimensional;analytical tool;Animals;Area;autoencoder;Behavior;Behavioral;behavioral study;Brain;cell type;Cells;Choice Behavior;Collaborations;Communication;Data;Data Analyses;data modeling;Data Reporting;Data Science;Data Set;Decision Making;Development;Dimensions;expectation;experimental study;Goals;Grooming;Individual;Individual Differences;International;Laboratories;Learning;Linear Models;machine learning method;Maps;markov model;Methods;Modeling;Mus;neural;neural circuit;neural correlate;neuromechanism;Noise;Nose;novel;Occupational activity of managing finances;open source;Output;parallelization;Positioning Attribute;Psychological reinforcement;Reaction Time;Reproducibility;Research Personnel;Rest;Signal Transduction;Software Tools;Space Models;Statistical Methods;Statistical Models;Task Performances;Testing;Time;Tongue;tool;Training;Work

PROJECT_TITLE: Behavioral Analysis and Modeling Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: STEINMETZ, NICHOLAS  (contact)

PROJECT_TERMS: Address;Algorithms;analytical method;Area;autism spectrum disorder;Basal Ganglia;Behavior;Behavioral;Behavioral Model;behavioral response;Brain;Brain region;cell type;Cerebellum;Communication;Complex;Data;Data Analyses;Data Collection;Data Science;Data Set;data sharing;Decision Making;density;design;Dimensions;Disease;Environment;Etiology;expectation;flexibility;Functional Magnetic Resonance Imaging;Goals;Histology;Individual;Infrastructure;International;Laboratories;Learning;Link;Mammals;Measurable;Measurement;Measures;Methods;Midbrain structure;Modeling;Mus;neural;neural circuit;neuromechanism;neuronal circuitry;Neurons;novel;Pattern;Perception;Performance;Population;response;Rotation;Route;Sensory;Shapes;Source;Standardization;Stimulus;Structure;Surveys;Task Performances;Techniques;technology development;Testing;Thalamic structure;Training;Triplet Multiple Birth;Work

PROJECT_TITLE: Influence of internal state on communication in distributed neuronal circuits