NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Public Health Relevance Statement This project will study romantic relationship influences on female sexual dysfunction. It will also establish which messages about sexual functioning align most with distinct demographic and attitudinal profiles of women’s romantic partners, providing an evidence base upon which to develop or adapt dyadic sexual functioning interventions for women and their partners.

PI_NAMEs: HARGONS, CANDICE  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Affect;Anxiety;Area;Arousal;Attitude;Black race;black women;Caregivers;Categories;cis-female;comparative;cultural values;Data;demographics;Depressed mood;Development;Diagnosis;Disease;Distress;DSM-V;Emotional;emotional distress;evidence base;experience;Face;Female;Female Orgasmic Disorder;Focus Groups;Functional disorder;Future;Gender;gender equity;Gender Role;Genitalia;Glean;Goals;Guilt;Health;Health Priorities;Household;Incidence;Individual;Inequity;innovation;interest;Internet;intersectionality;Intervention;Intervention Studies;Interview;Lived experience;Lubrication;Maps;Menopausal Status;Methods;Modeling;Morbidity - disease rate;Mothers;National Institute on Minority Health and Health Disparities;Orgasm;Pain;Pelvic Pain;Penetration;pleasure;Positioning Attribute;Predictive Factor;Premenopause;prevent;Process;Psychophysiologic Disorders;Quality of life;Race;racism;Reporting;Research;Research Methodology;Research Personnel;Role;Sampling;satisfaction;sex;Sex Functioning;sexual debut;Sexual Dysfunction;social structure;Societies;structural determinants;Surveys;Symptoms;Testing;theories;therapy development;Vagina;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Assessing Differential Dyadic Mechanisms of Women’s Sexual Functioning

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Narrative: Benzene is a ubiquitous environmental pollutant and a known hematopoietic toxin but little is known about the effect of benzene exposure on cardiovascular disease. The proposed study will examine the effect of benzene exposure on atherosclerosis, the underlying cause of most cardiovascular disease and stroke, and delineate the associated molecular mechanisms.

PI_NAMEs: SRIVASTAVA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: activating transcription factor 3;Adhesions;Adverse effects;Affect;Air;air filter;Air Pollution;Aorta;Apoptosis;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Automobile Exhaust;Benzene;Benzene Exposure;Benzoquinones;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Adhesion Molecules;Cell Physiology;Cells;Cessation of life;Chemicals;chronic inflammatory disease;cytokine;Cytoskeleton;Data;Deposition;Disease;Dose;drinking water;Dyslipidemias;Endothelial Cells;endothelial dysfunction;Endothelium;Environmental Pollutants;Environmental Pollution;Evaluation;Exposure to;Failure;Fibrosis;Foam Cells;forest fires;Gases;Gasoline;Hazardous Waste Sites;Health;Heat shock proteins;Hematopoietic;high efficiency particulate air filter;Human;Hydroquinones;immunotoxicity;In Vitro;Individual;Industrialization;Industry;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;Insulin Resistance;Knockout Mice;Lesion;leukemia;Leukocyte Rolling;Leukocytes;Lipid-Laden Macrophage;Lipoproteins;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Matrix Metalloproteinases;Mediating;Metals;migration;Modeling;Molecular;Molecular Chaperones;Molecular Target;Mus;Myocardial Ischemia;Natural Source;Nature;Necrosis;Non-Insulin-Dependent Diabetes Mellitus;Occupational Exposure;overexpression;Ozone;Particulate Matter;Persons;Petroleum;Play;pollutant;premature;prevent;Process;protein expression;protein folding;Protein Overexpression;Proteins;PTGS2 gene;Rattus;recruit;Relaxation;response;Role;Rupture;sex;Small Interfering RNA;Smooth Muscle Myocytes;Source;Stimulus;Stroke;Structure;superfund site;superoxide dismutase 1;Testing;Time;Tobacco smoke;Toxic effect;Toxin;transcriptome sequencing;Trichloroethylene;United States;Vascular Diseases;Vascular Endothelium;vascular inflammation;vascular injury;volatile organic compound;volcano;western diet

PROJECT_TITLE: Vascular Toxicity of Benzene

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Elderly women are disproportionally affected by atrial fibrillation (AF) and AF related dementia. We will examine the role of aging and genetic sex, XX (female) vs. XY (male), in the development of cardiac inflammation/fibrosis, AF and dementia. We will also test fibrosis inhibition as a sex-specific AF and dementia preventative therapy.

PI_NAMEs: MANWANI, BHARTI  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Age;aged;Aging;aging population;Animals;Anticoagulants;arm;Atrial Fibrillation;Autopsy;autosome;behavior test;Blood - brain barrier anatomy;blood perfusion;Brain;brain magnetic resonance imaging;Brain region;brain tissue;Calcium Signaling;Carbachol;Cardiac;Cardiac Electrophysiologic Techniques;cerebral atrophy;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Cholinergic Agonists;Chromosome 3;Chronic;Cognition;cohort;Complement;Complex;coronary fibrosis;cytokine;Data;Death Rate;Dementia;dementia risk;Development;Diagnosis;Disproportionately impacts women;Drug Targeting;Elderly woman;Electrocardiogram;Embolism;Enzyme-Linked Immunosorbent Assay;Esophagus;Estrogens;Event;expectation;Female;Fibrin;Fibrinogen;Fibrosis;Flow Cytometry;Four Core Genotypes;Functional disorder;Gene Deletion;Genes;Genetic;genotypic sex;Goals;Gonadal Steroid Hormones;Heart;Heart Atrium;Hemorrhage;Histology;Hormone replacement therapy;human tissue;Immunohistochemistry;Impaired cognition;Infarction;Infiltration;Inflammation;Inflammatory;inflammatory milieu;inhibitor;Injury;Integrins;Interleukin-6;ITGAM gene;ITGB2 gene;Lasers;Link;Macrophage;Magnetic Resonance Imaging;male;Maps;Measures;men;Microglia;Modeling;Morbidity - disease rate;Motor;mouse model;Mus;Myeloid Cells;Myocarditis;neuroinflammation;neuron loss;Neuronal Injury;neurovascular;neurovascular unit;old mice;Optics;Oral;Ovary;Parents;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Pirfenidone;Ploidies;Predisposition;prevent;Prevention;Preventive therapy;Public Health;Pulmonary Fibrosis;Radial;receptor;Risk;Risk Factors;Role;Saline;sex;Sex Chromosomes;Sex Differences;sexual dimorphism;Stroke;Stroke prevention;Testing;Testis;Thromboembolism;Tissues;Transforming Growth Factor beta;Trichrome stain;water maze;white matter injury;Wild Type Mouse;Woman;XX male;XY females;Y Chromosome;young woman

PROJECT_TITLE: On the Basis of Sex: The Role of Sex chromosomal complement in Atrial Fibrillation and Dementia

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: We have generated a vast amount of transcriptomic, metabolomic and proteomic data from a nine-day time course aimed at temporally defining the changing signaling and metabolic landscape contributing to the initiation and progression of molecular events promoting the epithelial to mesenchymal transition (EMT) in breast, lung and other cancers. These data have revealed several new links to EMT and metastasis, and we are currently focused on defining; (i) how ERK2 regulates chromatin remodeling and contributes to the initial phases of EMT via regulation of the HIRA complex and H3.3, (ii) how ERK2 signaling controls genetic and metabolic reprogramming to promote EMT-like features and metastatic progression via the SP1/EGR1-dependent down- regulation of genes suppressing metastatic behaviors and (iii) how ERK2 regulates extensive changes in membrane trafficking and lysosome biology for nutrient acquisition and survival and how differential expression of plasma membrane and lysosome membrane transporters during EMT, are regulated and contribute to cancer progression and invasion. These goals place us in the unique position to uncover and understand at a biochemical and molecular level new regulatory processes, new biomarkers and new potential targets for drug discovery, that are needed for personalized therapeutic intervention in many diseases, such as aggressive, metastatic cancers, a major unmet clinical need.

PI_NAMEs: BLENIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Applications Grants;Area;Automobile Driving;Autophagosome;Basic Science;Behavior;Binding;Binding Sites;Biochemical;Biological;Biological Markers;Biological Process;Biology;biomarker development;biomarker identification;Breast;cancer initiation;cancer stem cell;cancer therapy;Carcinoma;Cause of Death;Cell membrane;Cell Proliferation;Cells;Cessation of life;Characteristics;Chemoresistance;Chromatin;chromatin assembly factor I;chromatin remodeling;Clinical;Communities;Community Developments;Complex;Data;Development;differential expression;Disease;Disseminated Malignant Neoplasm;Docking;drug development;drug discovery;Drug resistance;drug resistance development;Drug Targeting;Early identification;Environment;Epithelial Cells;epithelial to mesenchymal transition;Event;expectation;Extracellular Signal Regulated Kinases;fighting;gene repression;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Grant;Growth;Histone H3;Histone H3.3;Histones;Immunotherapy;improved;In Vitro;in vivo;innovation;insight;interest;Invaded;Investigation;Laboratories;Link;Location;Lung;lysosome membrane;Lysosomes;Maintenance;Malignant Neoplasms;MAPK1 gene;Mediating;Medical;MEKs;Membrane;Membrane Transport Proteins;Mesenchymal;Metabolic;Metabolism;metabolomics;metastatic process;Modification;Molecular;Molecular Chaperones;mortality;Motility;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;Nutrient;Oncogenic;Oncology;Operative Surgical Procedures;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;personalized therapeutic;Pharmacotherapy;Phase;Phenotype;Play;Positioning Attribute;predictive marker;Prevalence;prevent;Prevention;Primary Neoplasm;Process;programs;Proliferating;promoter;Property;Protein Isoforms;Proteomics;Ras/Raf;Regulation;Role;Signal Transduction;small molecule;Solid Neoplasm;SP1 gene;success;Supporting Cell;System;targeted treatment;Therapeutic;Therapeutic Intervention;Time;Toxic effect;trafficking;transcription factor;transcriptional reprogramming;transcriptomics;transdifferentiation;treatment response;tumor growth;tumor progression;tumorigenic;Up-Regulation;Variant;Work

PROJECT_TITLE: Mitogenic and Oncogenic Regulation of ERK/RSK Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Wound Healing and Care

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This project proposes to test the hypothesis that skin necrosis over implants results from compression induced vascular necrosis leading to reduced skin elastic properties (skin damage), and eventually skin necrosis and implant exposure. Vascular ischemia and skin damage will be studied in an in vivo model, with photoacoustic tomography (PA), Doppler Ultrasound (US) and ultrasound elasticity (UE) respectively applied to measure vascular ischemia and skin damage in vivo. These measures will be correlated with implant shape and computationally predicted skin damage from nonlinear Finite Element continuum damage models.

PI_NAMEs: EMELIANOV, STANISLAV Y;HOLLISTER, SCOTT J (contact);ZOPF, DAVID ADAM

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: 3D Print;Acupressure;Animals;Area;Autologous;Biocompatible Materials;Biological;Biological Markers;Blood;Blood flow;Blood Vessels;Blood Volume;Cartilage;Clinical;clinical application;Complex;Complication;computerized tools;craniofacial;Data;design;Doppler Ultrasound;Ear;Elasticity;elastography;Elements;Excision;Exhibits;experimental group;Face;Family suidae;Female;Hypersensitivity skin testing;Image;imaging biomarker;imaging modality;Imaging Techniques;Implant;implant design;in vivo;in vivo imaging;in vivo Model;Infection;insight;Investigation;Ischemia;male;Measurement;Measures;mechanical properties;Mechanics;Methods;Miniature Swine;Modeling;Modulus;mouse model;Necrosis;Nose;Operative Surgical Procedures;optoacoustic tomography;Patients;Plastics;polycaprolactone;porcine model;Porosity;predictive modeling;Prevalence;Printing;Procedures;Property;prophylactic;reconstruction;Reporting;rib bone structure;Risk;scaffold;scoliosis;Shapes;Site;skeletal;Skin;skin damage;Skin graft;Spinal;Stress;Structure;Testing;Thick;Time;Tissues;tool;ultrasound;Vascularization

PROJECT_TITLE: Damage Modeling and Vascular Imaging Correlation with Implant Induced Skin Necrosis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The epithelial cells that line the intestinal tract build finger-like protrusions referred to as ‘microvilli’, which extend into the gut lumen and play essential roles in nutrient absorption and protection against infection. Despite occupying a critical physiological interface in the gut, there is little information on how microvilli are built and organized. The proposed studies seek to elucidate molecular pathways that control the assembly and organization of these protrusions during intestinal epithelial differentiation, and thus generate insight on the basis of human diseases characterized by loss of microvilli, which include enteric infections and inherited pathologies such as microvillus inclusion disease.

PI_NAMEs: TYSKA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Actins;Activities of Daily Living;Adhesions;Animals;Apical;Biological Models;Brush Border;Cell Line;Cells;cellular microvillus;Complex;Data;Defect;enteric infection;Enterocytes;Epithelial Cells;Epithelium;Exhibits;experimental study;Extracellular Space;Fingers;Funding;Goals;Grant;Growth;human disease;Image;Infection;Inflammatory Bowel Diseases;Inherited;insight;Intercellular Junctions;Intestinal Diseases;intestinal epithelium;Intestines;kidney epithelial cell;Knockout Mice;Learning;Link;loss of function;malformation;Malignant Neoplasms;Measurement;Medial;Membrane;Microscopy;Microvillus inclusion disease;Modeling;Molecular;monolayer;Morphogenesis;Morphology;Motility;mouse model;Mucins;novel;nutrient absorption;Pathology;Pathway interactions;Photobleaching;Physiological;Play;Positioning Attribute;Role;Seminal;Site;Structure;superresolution imaging;superresolution microscopy;Surface;Testing;Tight Junctions;Time;Tissues;Villus;Work

PROJECT_TITLE: Molecular basis of brush border assembly

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: RALEIGH

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative Cyclopropane, aza-cyclopropane (aziridine), and isocyano (isonitrile) moieties are unique functional groups used as pharmacophores in drugs (including FDA approved drugs for the treatment of hypertension, opioid addition, HIV, and cancers) and metal chelating agents, and it will therefore be valuable to develop effective strategies to access these novel functional groups. The recently discovered cyclopropanation, aziridination, and isonitrile formation catalyzed by iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) enzymes represent attractive strategies to install these important pharmacophores. In this project, a combined bioinformatics and retro-biosynthetic analysis will be applied to efficiently identify Fe/2OG enzymes with these targeted activities in genomic sequence data; the identified Fe/2OG enzymes will subjected to mechanistic investigations, and the acquired mechanistic insights will be used to innovate chemo-enzymatic methods to prepare cyclopropane, aziridine, and isonitrile, the three novel functional groups widely used in synthetic chemistry and drugs.

PI_NAMEs: CHANG, WEI-CHEN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acids;Active Sites;Address;alpha ketoglutarate;Amines;Anabolism;analog;Area;azetidine;Aziridines;Binding;Biochemistry;Bioinformatics;bioinformatics tool;Biological Assay;Biology;Biomimetics;carbon skeleton;Cell Survival;Chelating Agents;chemical function;Chemical Structure;Chemicals;Cluster Analysis;Cobalamin;cofactor;Comparative Study;Complex;Computer Models;Cyclization;cyclopropane;Data;Databases;Decarboxylation;design;Development;drug development;Engineering;Enzyme Kinetics;Enzymes;Epoxy Compounds;Fatty Acids;FDA approved;ferryl iron;Flavins;functional group;Funding;Gene Cluster;Genome;genomic data;Genomic Library;Genomics;halogenation;hands-on learning;heme a;HIV;Hydrolysis;Hydroxylation;hypertension treatment;Individual;innovation;insight;Investigation;Iron;Kinetics;Knowledge;Label;Life;Machine Learning;Malignant Neoplasms;Maps;member;metalloenzyme;Metals;Methods;Mixed Function Oxygenases;Molecular Probes;Mononuclear;Mossbauer Spectroscopy;mutation screening;Natural Products;Nature;Neighborhoods;NMR Spectroscopy;novel;Opioid;Organic Synthesis;Outcome;Oxygen;Oxygenases;pathogenic bacteria;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacophore;Pharmacotherapy;Physiologic pulse;polyketides;predictive modeling;Preparation;Prevalence;Process;Property;protein structure;protein structure prediction;Proteins;Pyridoxal Phosphate;Rationalization;Reaction;Ribosomes;Roentgen Rays;Role;Route;S-Adenosylhomocysteine;S-Adenosylmethionine;Scientist;screening;secondary metabolite;Sequence Alignment;Site;small molecule;Source;stereochemistry;Structure;Sulfur;Synthesis Chemistry;synthetic drug;Terpenes;Testing;tool;trafficking;Uncertainty;Vanadyl;Work

PROJECT_TITLE: Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile Formation

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Improved point-of-care tests for tuberculosis (TB) are needed to enable more timely and accurate diagnosis. In light of its portability, relatively low cost, and good diagnostic accuracy for pulmonary disease, lung ultrasound is a potentially promising new tool for point-of-care TB diagnosis. We will carry out a study to evaluate the potential of lung ultrasound for pulmonary tuberculosis.

PI_NAMEs: BLAIR, PAUL ;GILMAN, ROBERT H (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: accurate diagnosis;Address;Adult;Africa South of the Sahara;algorithm training;Area;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;Biological;Biological Testing;Blinded;Characteristics;Classification;Clinical;Clinics and Hospitals;community acquired pneumonia;convolutional neural network;cost;Data;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;Diagnostic Imaging;Disease;Enrollment;Equipment;Evaluation;evaluation/testing;experience;Foundations;Goals;Healthcare;Human;Human Resources;Image;Imaging technology;improved;indexing;Infrastructure;Interdisciplinary Study;laptop;Lesion;Light;low and middle-income countries;Lung;Lung Diseases;Modality;Modeling;mortality;Neural Network Simulation;neurodevelopment;novel;Outpatients;Participant;Patient Triage;Patients;Persons;Peru;Peruvian;Pleura;Pneumonia;point of care;point of care testing;point-of-care diagnostics;portability;prisma;Procedures;Pulmonary Edema;Pulmonary Tuberculosis;Radiation;Reference Standards;Research Project Grants;resilience;Resource-limited setting;Resources;Respiratory Signs and Symptoms;Scanning;Sensitivity and Specificity;Specificity;Standardization;Structure of parenchyma of lung;supply chain;Symptoms;Technology;Testing;Thoracic Radiography;Time;tool;Training;Triage;Tuberculosis;Tuberculosis diagnosis;Ultrasonography;ultrasound;United States;Universities;Validation;Work

PROJECT_TITLE: Lung Ultrasound and Artificial Intelligence Technology for the Diagnosis of TB in LMICs

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Innovative homogeneous catalytic methods play an increasingly important role in chemical synthesis of pharmaceuticals. This proposal outlines new reactions based on nonmetal phosphorus-based catalysts that strengthen our ability to access classes of molecules relevant to human health.

PI_NAMEs: RADOSEVICH, ALEXANDER T (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthetic Methods based on Biphilic Phosphorus Catalysts

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Genetics;Mental Health;Neurosciences;Pain Research;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Chronic pain after traumatic stress exposure is more common in women, and mechanisms of chronic pain development in men and women appear to differ. We propose a series of genomic, molecular, and behavioral studies evaluating how microRNA, master regulators of the mammalian transcriptome, influence chronic pain development after traumatic stress exposure in men and women. These experiments will provide important new insights into sex-specific mechanisms of CMSP development and will identify novel therapeutic strategies for both sexes.

PI_NAMEs: LINNSTAEDT, SARAH  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Accelerometer;Accounting;Address;Affect;Animal Model;Animals;Automobile Driving;Award;Behavior;Behavioral;behavioral study;Biological;Biological Models;Biological Response Modifiers;Biology;Cells;chronic musculoskeletal pain;chronic pain;circadian;Circadian Rhythms;clinical predictors;cohort;Cohort Analysis;cytokine;Cytometry;Data;Data Analyses;data modeling;Development;differential expression;Enrollment;Estradiol;Etiology;experience;experimental study;Female;Gene Expression;Genomics;Human;Hyperalgesia;Hypersensitivity;Immune;improved;Individual;Inflammatory;Influentials;Innate Immune Response;Innate Immune System;insight;Interleukin-6;Intervention;knock-down;Knowledge;male;Measures;Mediating;Mediation;men;MicroRNAs;miRNA expression profiling;Modeling;Molecular;multidisciplinary;Nerve Tissue;Neuroimmune;neuropsychiatric disorder;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pain;pain chronification;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patient Self-Report;Periodicity;Phenotype;Physiological;Play;post-traumatic stress;prevent;Prevention;Prevention strategy;prospective;Rattus;Regulation;Repression;Role;RORA gene;Sampling;Sensory;Series;sex;Sex Differences;Signal Transduction;small hairpin RNA;Specificity;Stress;Survivors;System;Testing;therapeutic target;TLR4 gene;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Trauma;traumatic stress;Woman;Work;X Chromosome

PROJECT_TITLE: Sex-dependent microRNA-mediated pathways to chronic musculoskeletal pain following trauma

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The dopamine system has been widely studied to elucidate the reinforcing properties of substance abuse, but far less is known on how this system regulates how cues, for example, drug-associated words or environments, act to trigger drug self-administration. Our research investigates how these cues become associated with outcomes and meaning, which appears to require dopamine-dependent changes in specific synaptic connections between auditory inputs to neurons that control decision making. This project explores how these learning-dependent changes occur in the brain, and the results are expected to contribute to understanding the brain mechanisms driving substance abuse, as well as symptoms of disorders including hallucinations in psychosis, attention deficit, post-traumatic stress disorder and deficits in language learning in neurodevelopmental disorders including autism.

PI_NAMEs: SULZER, DAVID  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;Adderall;Address;Amphetamines;Anesthesia procedures;Animal Behavior;antagonist;Antipsychotic Agents;Anxiety;Association Learning;Attention deficit hyperactivity disorder;Attentional deficit;Auditory;Auditory area;Auditory Hallucination;auditory stimulus;autism spectrum disorder;Automobile Driving;awake;Axon;Behavior;Behavioral;behavioral response;Biochemical;Brain;Cannabinoids;Chemosensitization;cholinergic;CNR1 gene;Cocaine;cocaine self-administration;Complex;Conditioned Stimulus;Corpus striatum structure;Coupled;Cues;Decision Making;Disease;Dopamine;Dopamine Receptor;dopamine system;Dorsal;Drug Addiction;Electrophysiology (science);Environment;experimental study;Freezing;Fright;Glutamates;Habits;Hallucinations;in vivo;Individual;Intellectual functioning disability;Interneurons;Language Development;Language Disorders;learned behavior;Learning;Learning Disorders;learning engagement;Long-Term Potentiation;Measures;Mediating;Midbrain structure;Modification;Molecular;monoamine;Mood Disorders;Motor;Movement;Mus;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neurotransmission;Noise;novel;Nucleus Accumbens;Opioid;optogenetics;Outcome;Pathway interactions;Periodicity;Pharmaceutical Preparations;Phase;Photometry;Physiological;Play;Post-Traumatic Stress Disorders;Property;Psychoses;psychostimulant;receptor;Regulation;Research;response;Response to stimulus physiology;Rewards;Ritalin;RNA analysis;Role;Safety;Schizophrenia;Self Administration;Sensory;Serotonin;Signal Transduction;skill acquisition;Slice;Social Development;sound;Stimulus;Substance abuse problem;Symptoms;Synapses;Synaptic plasticity;System;Tail;Testing;Thalamic structure;Time;Training;transmission process;Work

PROJECT_TITLE: The Dopamine Synapse and Associative Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This study aims to discover the causes for sleep-wake disturbances that afflict patients with Alzheimer's Disease and Progressive Supranuclear Palsy. We will determine if the pattern of disturbed sleep in these two disorders is predicted by neuropathological and molecular changes in key areas that regulate sleep and wake in both human brain bank specimens and a subsample of patients who complete sleep measures and undergo autopsy.

PI_NAMEs: GRINBERG, LEA TENENHOLZ;NEYLAN, THOMAS C (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Area;Automobile Driving;Autopsy;Behavior;Biological Specimen Banks;Brain;Brain Stem;Cell Nucleus;Cessation of life;Clinical;cohort;Collection;Coupling;Data;Deposition;Development;Dimensions;Disease;Drug Targeting;effective therapy;Electroencephalography;Excessive Daytime Sleepiness;Funding;Gene Expression;Genes;Grant;Graph;Human;hypocretin;Hypothalamic structure;In Situ;Individual;innovation;Institutionalization;Lateral;Lateral Hypothalamic Area;Link;Maps;Measures;Mediating;Methods;Microglia;Modeling;Molecular;Molecular Profiling;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neuroregulation;Neurotransmitters;non rapid eye movement;novel;Pathogenicity;Pathway Analysis;Patients;Pattern;Peptide Receptor;Peptides;Pharmaceutical Preparations;Phenotype;Physiology;Polysomnography;Progressive Supranuclear Palsy;Proteins;Proteomics;Publishing;receptor;Recovery;response;Rest;Site;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep pattern;Sleep Stages;Sleeplessness;Structure;System;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Transcript;transcriptomics;Up-Regulation

PROJECT_TITLE: Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common neurodegenerative disorder, currently accounting for 60–80 % of dementia cases. This application aims at identifying the mechanisms underlying systemic inflammation and neuroinflammation during aging and in AD and exploring genetic susceptibility to AD.

PI_NAMEs: LU, XIN-YUN  (contact);WEINTRAUB, NEAL L

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: abeta accumulation;Abeta clearance;Ablation;Accounting;Address;Adult;Affinity;African American population;Age;age acceleration;age related neuroinflammation;Age-associated memory impairment;Aging;aging brain;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Antigen Receptors;Asian population;Behavior;Binding;Binding Proteins;Biological Availability;Blood Cells;Brain;Buffers;Caucasians;CCL2 gene;cell type;Cells;Cerebral cortex;chemokine;chemokine receptor;Chronic;Co-Immunoprecipitations;Cognitive;Cognitive deficits;cytokine;Data;Dementia;Disease Progression;Encephalitis;erythrocyte receptor;Erythrocytes;Erythroid;European;Exhibits;Genetic Predisposition to Disease;Genotype;Glutamates;Hematopoietic;Hippocampus;Human;Immune system;Impaired cognition;In Vitro;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interleukin-6;Invaded;Knock-in Mouse;Knockout Mice;Link;Malaria;malaria infection;Mediating;member;Microglia;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;neuroprotection;novel;overexpression;Pathology;Peripheral;personalized approach;Phenotype;Plasmodium vivax;Play;Predisposition;Prefrontal Cortex;pressure;Process;Promoter Regions;Property;Prosencephalon;protective effect;Protein Isoforms;racial difference;receptor;Role;Short-Term Memory;Signal Transduction;Synaptic plasticity;systemic inflammatory response;tau Proteins;Testing;TNF gene;transgene delivery;Variant;Wild Type Mouse;Work

PROJECT_TITLE: DARC, Inflammaging and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative The insulin-like growth factor (IGF) system has a central role in a number of human diseases including growth disorders, thyroid eye disease, chronic kidney diseases and various cancers. We recently showed for the first time that viruses have insulin/IGF-1 like peptides that are natural inhibitors of the IGF-1 receptor (IGF1R). The proposed experiments on these viral IGF1R inhibitors will enhance our understanding of IGF1R inhibition and provide valuable insights for the development of peptide therapeutics to treat IGF-1 related diseases.

PI_NAMEs: ALTINDIS, EMRAH  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acromegaly;Acute;Affect;Affinity Chromatography;Agonist;antagonist;anti-cancer research;Binding;Biological Assay;Blood;bovine growth hormone;Breast Cancer Model;C-Peptide;Cancer Patient;cell growth;Cell Physiology;chemical synthesis;Chronic;Chronic Kidney Failure;Clinical;Collection;Complex;Cryoelectron Microscopy;Data;Dependovirus;design;Development;Diabetic Nephropathy;Disease;DNA;experimental study;Family;Fc Receptor;Fellowship;Fishes;Gene Expression;Genes;glucose metabolism;glucose tolerance;glucose uptake;Goals;Grant;Growth;Growth Disorders;Hormones;Human;human disease;IGF1R gene;immunodeficiency;Impairment;In Vitro;in vivo;in vivo Model;Infusion procedures;inhibitor;Injections;innovation;insight;Insulin;Insulin Antagonists;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin-Like Growth Factor I;insulin-like peptide;Insulin-Like-Growth Factor I Receptor;Iridoviridae;Knowledge;Label;Laron Syndrome;Ligands;Liver;Malignant Neoplasms;Mammals;Maps;Mediating;member;Metabolic;Metabolism;Modeling;Molecular;Molecular Target;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;overexpression;peptide drug;Peptides;phosphoproteomics;Play;Postdoctoral Fellow;Production;Proliferating;promoter;Proteins;Proteomics;Ranavirus;receptor;receptor expression;receptor function;Receptor Inhibition;Receptor Signaling;recruit;Research;Role;Satellite Viruses;Serum;Signal Pathway;Signal Transduction;Somatomedins;Structure;Structure-Activity Relationship;System;Techniques;Testing;three dimensional structure;thyroid associated ophthalmopathies;Time;Tissues;tool;transcription factor;tumor;tumor progression;Vena caval structure;Viral;Virus;Virus Diseases;Work;Xenograft procedure

PROJECT_TITLE: Viral insulin-like peptides and their unique activities on mammalian insulin/IGF-1 system

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative This project will be the largest multimodal longitudinal study in children and adolescents attempting to identify robust neural and mental health correlates and consequences specific to three Screen Media Activity (SMA) types: active (i.e., videogaming), passive (i.e., watching TV and videos) and mixed (i.e., texting and using social media). Its innovation lies in the multi-modal and longitudinal characterization of the children and the use of twin- studies and sophisticated analytic methods to identify probable causal mechanisms involving SMA types. The rationale for the proposed research is that, once the neurobiological mechanisms mediating the relationship among SMA, mental health and brain development are understood, and modifiable factors identified, targeted prevention approaches and policy initiatives can be developed.

PI_NAMEs: CHAARANI, BADER  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent mental health;Adult;Affect;Age;Aggressive behavior;analytical method;Anxiety;Attention deficit hyperactivity disorder;Bayesian Network;Behavior;Behavioral;Body mass index;Brain;brain morphology;Child;Child Development;Child Mental Health;Childhood;Cognition;cognitive development;cognitive function;cognitive task;Communication;Complex;COVID-19 pandemic;Data;data collection site;Data Set;design;Development;Dimensions;Dose;early adolescence;emotion regulation;Emotional;Emotions;Environment;experience;Exposure to;Functional Magnetic Resonance Imaging;Genetic;Goals;gray matter;Hour;improved;innovation;Intervention;Leadership;longitudinal design;Longitudinal Studies;Machine Learning;machine learning prediction;Measures;media use;Mediating;Mental Depression;Mental Health;Methodology;Modeling;Motor;multimodal data;multimodality;multisensory;neural;neurobiological mechanism;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Outcome;Paper;Pattern;peer;Persons;Physical activity;Physiology;Policies;Policy Maker;prevent;Prevention approach;Probability;Process;Psyche structure;Psychopathology;Puberty;Publishing;Reading;Recreation;Reproducibility;Research;response;reward processing;Risk;Sampling;Short-Term Memory;Site;Sleep Disorders;social media;System;Testing;Text Messaging;theories;Thick;Time;tv watching;Twin Multiple Birth;Twin Studies;video chat;Video Games

PROJECT_TITLE: Tracking the impact of screen media activity on mental health, cognition and the brain from childhood to adolescence in the longitudinal ABCD study


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Structural basis for pathway-selective signaling by the µ-opioid receptor. The goal of this proposal is to determine the structural basis for the versatile signaling behavior of the µ-opioid receptor. The µ-opioid receptor is the most effective therapeutic target for the treatment of acute and chronic pain; however, the use of opioid drugs acting at this receptor is a leading cause of death by overdose in North America and Europe. This proposal will provide structural insights that will facilitate the development of safer and more effective drugs for opioid receptors.

PI_NAMEs: KOBILKA, BRIAN K (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Acute pain management;addiction;Adverse effects;Agonist;Analgesics;analog;arrestin 2;arrestin3;Arrestins;Behavior;Binding;biophysical techniques;Cause of Death;chronic pain;Clinical;Codeine;Complex;Coupled;Coupling;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Tail;Development;Dose Limiting;drug action;Electrons;Europe;Exhibits;experience;Fentanyl;Fluorescence Resonance Energy Transfer;Goals;GTP-Binding Proteins;improved;insight;Maps;Mediating;Medicine;mitragynine pseudoindoxyl;Molecular Conformation;Monitor;Morphine;Mus;North America;novel;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;opioid mortality;Opioid Receptor;Opioid Receptor Binding;opioid use;overdose death;Pain;particle;Pathway interactions;Patients;Pharmaceutical Preparations;plasma protein Z;Property;Protein Isoforms;Quality of life;receptor;respiratory;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;single molecule;Spectrum Analysis;Structure;Structure-Activity Relationship;Surface;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Time;tool;Ventilatory Depression

PROJECT_TITLE: The structural basis for pathway-selective signaling by the µ opioid receptor

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Contraception/Reproduction;Gene Therapy;Genetics;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE  This study will be highly significant in establishing a therapeutic modality to prevent the maternal and infant vascular dysfunction that is caused by improper SAR early in pregnancy. Non-invasive UMGD delivery of VEGF selectively to the maternal aspect of the placenta represents an innovative approach to reverse the decline in SAR and link it to vascular function in the mother and offspring. Reversing the defect in SAR by VEGF gene delivery will be foundational in developing a similar therapeutic modality to prevent the devastating complications of vascular dysfunction in the human mother and newborn elicited by impaired SAR.

PI_NAMEs: ALBRECHT, EUGENE D. (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acetylcholine;Basal Plate;Biological Assay;Biological Availability;Birth;Blood capillaries;Blood Vessels;brachial artery;Cells;contrast enhanced;Defect;density;early pregnancy;Endothelial Cells;Endothelium;Estradiol;Fetal Development;Fetal Growth;Fetal Reduction;Fetus;First Pregnancy Trimester;Foundations;Gene Delivery;Gene Targeting;Growth Factor Gene;Human;Hyperemia;Image;Image Analysis;Immunofluorescence Immunologic;Impairment;Incidence;Infant;innovation;Invaded;Ligation;Link;maternal serum;Mediating;Messenger RNA;Methods;Microbubbles;Modality;Modeling;Morbidity - disease rate;mortality;Mothers;Names;Newborn Infant;Nitric Oxide Synthase;nonhuman primate;novel;offspring;Papio;Perfusion;Perinatal;Perinatal mortality demographics;Placenta;Pre-Eclampsia;Pregnancy;prevent;Primates;Proteins;Publishing;receptor;Resistance;Reverse Transcriptase Polymerase Chain Reaction;shear stress;Skeletal Muscle;spatiotemporal;Spiral Artery of the Endometrium;targeted delivery;Testing;Therapeutic;trophoblast;Ultrasonography;ultrasound;Uterus;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vascular remodeling;Villous

PROJECT_TITLE: VEGF Gene Delivery In The Primate To Prevent Defective Spiral Artery Remodeling And Maternal Vascular Dysfunction

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE Our proposal relies on a multidisciplinary effort between researchers with complementary expertise to investigate the pathogenic potential for tubulin post-translational modifications (PTMs) in the onset of chemotherapy induced peripheral neuropathy (CIPN) and the mechanisms of CIPN-related drug dependent induction of tubulin and microtubule injury. In the short-term, our studies will examine a novel unifying theory of pathogenesis based on alteration of tubulin PTMs and determine the role for delta-2 tubulin in the onset of neuropathic damage induced by CIPN-promoting drugs by interfering with mitochondrial and TRP channel function. In the long-term, this work has the potential to reveal tubulin perturbation as the driver of axonal dysfunction caused by chemotherapeutics and to identify novel targets that may be modulated in drug therapies aimed at rescuing other chemotherapy- related adverse sequelae such as nephrotoxicity or ototoxicity as well as idiopathic or inherited forms of peripheral neuropathy in addition to CIPN.

PI_NAMEs: BARTOLINI, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Ablation;Acute;Adult;Adverse effects;Affect;afferent nerve;Afferent Neurons;Agonist;Alkylating Agents;alpha Tubulin;anti-depressive agents;Anticonvulsants;Antineoplastic Agents;Axon;axon injury;axonal degeneration;axonopathy;Behavior;Behavioral Assay;Biopsy;Bortezomib;Cancer Patient;Cell model;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chronic;Cisplatin;Collaborations;Communication;comparative;Complication;Data;Development;Disease;Dissociation;Distal;Dose;drug action;Drug usage;Endoplasmic Reticulum;Enzymes;Excision;Fiber;Fluorouracil;Functional disorder;Genes;high risk;Human;Hyperalgesia;Image;In Vitro;in vivo;in vivo evaluation;Inherited;inhibitor;Injury;insight;Intravenous;lentiviral-mediated;LoxP-flanked allele;Measures;mechanical allodynia;Mechanics;Mediating;Membrane Potentials;Microtubules;Mitochondria;Modeling;Modification;Molecular;Motor;multicatalytic endopeptidase complex;multidisciplinary;Mus;nephrotoxicity;Nerve;nerve damage;Neurologic;Neurons;Neuropathy;neurotoxic;novel;Opioid Analgesics;Oral;ototoxicity;overexpression;Oxygen Consumption;Paclitaxel;Pain;painful neuropathy;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Peripheral;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Pharmacotherapy;Play;Post-Translational Protein Processing;Pre-Clinical Model;prevent;Production;Proteasome Inhibitor;Protocols documentation;Publishing;Quantitative Evaluations;Regulation;Research Personnel;Role;sciatic nerve;Sensory impairment;Sensory Nerve Endings;Signal Transduction;Skin;spontaneous pain;sural nerve;taxane;Testing;theories;Therapeutic;Thermal Hyperalgesias;Time;Tissues;TRP channel;Tubulin;Vinca Alkaloids;Vincristine;Work

PROJECT_TITLE: Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE At the heart of cleaning and disinfection (C&D) conducted by nurses is a “risk-risk tradeoff”: increased C&D leading to increased work-related asthma risks and simultaneous decreased occupational infection risks. Translation of risk-risk tradeoff methods to respiratory health research and understanding barriers to C&D policy change will enable and identify feasible policy change strategies that protect nurses at their acceptable risk levels.

PI_NAMEs: WILSON, AMANDA MARIE (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Age;Airway Disease;American;Arizona;Asthma;Awareness;behavioral economics;Bioethics;Budgets;Chest;Competence;Consensus;Data;design;Discipline of Nursing;Disinfection;disorder risk;Environment;Environmental Health;Equipment and supply inventories;Ethnic Origin;Evaluation;experience;Face;Faculty;Frequencies;Future;Gender;Goals;Health;Health Personnel;Health Policy;Health Professional;Health protection;healthcare-associated infections;Heart;Hospitals;Human Resources;implementation intervention;Infection;infection risk;informant;Institution;Intervention;Interview;Knowledge;Legal;Measures;Mentors;Methodology;Methods;microbial;Modeling;National Heart, Lung, and Blood Institute;Nurses;Nursing Staff;Occupational;Occupational Asthma;Occupational Health;Patients;Performance;Pilot Projects;Policies;Policy Analysis;preference;Protocols documentation;Public Health;Qualitative Methods;Qualitative Research;Race;recruit;Registered nurse;Research;respiratory;Respiratory Disease;respiratory health;Risk;Risk Assessment;risk perception;Services;Societies;Specialist;Subgroup;Surveys;Text;Training;training opportunity;Translating;Translations;Universities;Viral;Work;Workers' Compensation;Workplace

PROJECT_TITLE: Work-related Asthma Risks for Nursing Staff Conducting Cleaning and Disinfection: Translation of Risk-risk Tradeoff Methodology

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Proteostasis, or protein homeostasis, is the balance between the accumulation of damaged proteins and protein degradation capabilities. This project examines the role of proteostasis in Plasmodium falciparum artemisinin resistance and focuses on the proteasome, ubiquitination, and the unfolded protein response in Southeast Asian and African parasites. Targeting proteostasis in P. falciparum parasites represents a new paradigm to treat artemisinin-resistant malaria.

PI_NAMEs: NG, CAROLINE L (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;Africa;African;Alkylation;Anti-malarial drug resistance;Anti-malarials;Antimicrobial Resistance;Area;Artemisinins;Cambodian;Cell Signaling Process;Cessation of life;Clinical;cohort;combat;Combined Modality Therapy;coronin protein;Data;Defect;Development;Disease;DNA Sequence Alteration;Endocytosis;Enzymes;Equilibrium;Etiology;Falciparum Malaria;falls;Future;Genes;Genetic Markers;global health;Goals;Heme;Knowledge;Malaria;Mediating;misfolded protein;Molecular;Multi-Drug Resistance;multicatalytic endopeptidase complex;mutant;Mutation;National Institute of Allergy and Infectious Disease;new therapeutic target;Outcome;Parasite resistance;Parasites;Pathway interactions;Pattern;Peptides;Plasmodium;Plasmodium falciparum;Population;Predisposition;Process;Proteasome Inhibition;Proteasome Inhibitor;protein degradation;Proteins;Proteolysis;proteostasis;Recommendation;Regulation;Research;Resistance;Resolution;response;Role;Set protein;Signal Transduction;southeast Asian;Southeastern Asia;synergism;System;Testing;therapeutic development;Treatment Efficacy;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;World Health Organization

PROJECT_TITLE: Proteostasis in Plasmodium falciparum artemisinin resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Public health relevance: This project will generate and apply statistical tools for analyzing large-scale genomic studies. The tools will help scientists tackle a diverse range of problems, including understanding the effects of genetic variation on fundamental biological processes, identifying collections of related genes that may help inform or explain new experimental results, and discovering relationships and clustering among samples (e.g., cells, genes or people), for example to identify cell or disease sub-types. Solving these problems has the potential to help understand the biology of disease, eventually leading to new therapies or treatment strategies.

PI_NAMEs: STEPHENS, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Acceleration;Address;Admixture;Area;ATAC-seq;Biological;Biological Assay;Biological Factors;Biological Process;Biology;cell type;Cells;ChIP-seq;Collection;Communities;Complex;Computer software;Computing Methodologies;Data Analyses;Development;dimension reduction;Disease;disorder subtype;Gene set enrichment analysis;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome analysis;genomic data;Genomics;Goals;High-Throughput Nucleotide Sequencing;human population genetics;improved;indexing;International;Joints;Location;Maps;Measures;Methodology;Methods;Modeling;Molecular;Mutation;novel strategies;novel therapeutics;Ontology;open source;Pathway interactions;Patients;Persons;Population Genetics;Positioning Attribute;Principal Component Analysis;public health relevance;Publishing;Research Personnel;Sampling;Scientist;single cell genomics;Specific qualifier value;Statistical Methods;Structure;Techniques;Testing;Time;tool;trait;transcriptomics;treatment strategy;Uncertainty;user-friendly;Work

PROJECT_TITLE: Genome analysis:  statistical methods and applications

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: This proposal is relevant to public health as it addresses how microglia, a cell implicated in Alzheimer's disease (AD) by human genome-wide association studies, are involved in disease pathogenesis. Although microglia surround amyloid-β plaques, one of the main pathologies of AD, there is still little known about what their response to plaques does to the brain – whether it is beneficial or detrimental. Upon completion, this project will not only identify the distinct role of these cells during disease, but also provide an innovative tool to study and target plaque-associated microglia, as well as insight into novel therapeutic strategies for AD.

PI_NAMEs: GREEN, KIM  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Address;Adult;Age;age related changes;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Animal Model;Antibiotics;Behavior assessment;Binding;Brain;brain cell;Brain Injuries;cell injury;Cell Physiology;Cells;Central Nervous System;Classification;Cognition;cognitive function;Complex;Demyelinations;Development;Disease;Disease associated microglia;Disease Progression;Enterobacteria phage P1 Cre recombinase;Environment;Excision;Future;gain of function;Gene Expression;Gene Expression Profiling;Genes;genome wide association study;Growth;Heterogeneity;Homeostasis;hTau Mice;Human Genome;Immune;Immunity;Immunotherapy;Inflammasome;Injury;innovation;insight;Knock-out;Knockout Mice;Label;Late Onset Alzheimer Disease;Light;LoxP-flanked allele;Macrophage;Maps;Microglia;Modeling;mouse model;Mus;nervous system development;Neurites;Neurodegenerative Disorders;neurofilament;Neuroglia;neuron loss;Neurons;neurotoxic;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Plasma;Play;Population;Process;Public Health;Reporter;Research Personnel;response;Role;Senile Plaques;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Surveys;Synapses;System;Tamoxifen;tau Proteins;Technology;Therapeutic;therapy development;Tissues;tool;transcriptome sequencing;transcriptomics;Transgenes;TREM2 gene;Trimethoprim;Variant;white matter

PROJECT_TITLE: Role of Disease-Associated Microglia in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Nanotechnology;Prevention;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative Our preliminary results demonstrate that targeting MDA-9 using the pharmacological inhibitor PDZ1i sensitizes metastatic breast tumor cells to conventional therapeutics. This proposal intends to characterize the mechanism by which PDZ1i, administered in a nanoformulation (PDZ1i-Nano), controls TNBC progression (growth and cellular dissemination) and sensitizes breast cancer cells to the toxic effects of chemotherapies and determine if these responses are enhanced further in terms of preventing metastasis when PDZ1i is used in combination with standard of care chemotherapies.

PI_NAMEs: DAS, SWADESH K;FISHER, PAUL B (contact);LANDRY, JOSEPH WILLIAM

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 4T1;Address;Adjuvant;advanced breast cancer;Animals;Appearance;aqueous;ATAC-seq;Binding;Binding Proteins;Bioinformatics;Biological Assay;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;Cause of Death;Cell Culture Techniques;Cell Mobility;cell motility;Cells;Characteristics;chemotherapy;Clinical;clinical application;clinical efficacy;Clinical Trials;combinatorial;cytotoxic;Data Set;Disease;Disease Progression;disorder control;Disseminated Malignant Neoplasm;Drug Kinetics;Effector Cell;Epigenetic Process;Evaluation;experimental study;FDA approved;gain of function;Gene Expression;Gene Targeting;Genes;Genetic;genome-wide;Goals;Growth;Human;humanized mouse;Immune;Immune system;immunoregulation;improved;In Vitro;in vivo;Infiltration;inhibitor;innovation;Invaded;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Melanoma differentiation associated gene-9;Metastatic breast cancer;Modeling;Monoclonal Antibodies;Motility;mouse model;Mus;nanocrystal;nanoformulation;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenes;Outcome Study;Paclitaxel;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;Phenotype;Positioning Attribute;pre-clinical;prevent;Primary Neoplasm;programs;Property;Publishing;rational design;recruit;Research;response;Role;Signal Pathway;Site;small molecule inhibitor;Solid;standard of care;Structure;Survival Rate;Technology;Therapeutic;Time;Toxic effect;Toxicity Tests;transcription factor;transcriptome sequencing;translational potential;triple-negative invasive breast carcinoma;tumor;tumor growth;Work;Xenograft Model

PROJECT_TITLE: Modulating growth, progression and metastasis in breast cancer by inhibiting MDA-9

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Ataxia Telangiectasia;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE There are no effective therapies for Ataxia Telangiectasia (A-T)—a catastrophic and lethal neurologic disease in children. We propose to utilize a recently generated animal model of A-T that for the first time displays the progressive loss of motor coordination (i.e., ataxia) and cerebellar atrophy that is a hallmark of the disease. Employing this new model, we will use cutting edge methods to examine the relationship between deleterious changes in the cerebellum and the progressive development of a severe form of ataxia.

PI_NAMEs: MATHEWS, PAUL JAMES (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Action Potentials;Affect;Age;Age Years;Animal Experimentation;Animal Model;APTX gene;Architecture;Area;Ataxia;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;ATM deficient;ATM gene;Atrophic;awake;behavior measurement;Behavioral;Brain;Cells;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Cessation of life;Child;Chromatin;Clinical;clinical phenotype;clinically relevant;Communication;Cre-LoxP;Defect;Dendrites;density;Development;Disease;DNA Damage;DNA Repair Gene;DNA Repair Pathway;Down-Regulation;effective therapy;Electrodes;Electrophysiology (science);Etiology;experimental study;Frequencies;Functional disorder;Gene Expression;gene repression;Genes;Genetic;Genotoxic Stress;Histologic;Histology;Human;Image;immunodeficiency;Immunohistochemistry;In Vitro;in vivo;Knock-out;Knockout Mice;Knowledge;Link;Live Birth;loss of function;Malignant Neoplasms;Measurement;Membrane;Methods;Modeling;Molecular;Morphology;Motor;mouse model;multi-electrode arrays;Mus;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;neural;neural circuit;neurogenetics;Neuronal Dysfunction;Neurons;neurotransmission;new therapeutic target;novel;Output;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;pharmacologic;Pharmacology;Phenotype;Physiological;Physiology;Play;postnatal;postsynaptic;pre-clinical;premature;presynaptic;Property;Protein Deficiency;Proteins;Regulation;Regulator Genes;Research;Research Personnel;response;Rest;Role;Severities;Signal Transduction;Structure;Symptoms;Synaptic plasticity;System;Techniques;Testing;Thalamic structure;therapeutic development;Time;transcriptomics;translational study;Variant;Work

PROJECT_TITLE: Defining cerebellar pathophysiology in Ataxia Telangiectasia


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Lower extremity peripheral artery disease (PAD) is an atherosclerotic disease that is associated with increased levels of arterial calcification above and below the knee, which decreases blood flow and perfusion to the calves and feet, and increases risk of non-healing wounds, limb loss, and death. Our research team developed a novel PET/CT imaging paradigm that provides absolute measures of skeletal muscle perfusion within specific muscle groups and vascular territories of the lower extremities that correspond with adverse remodeling of skeletal muscle and PAD symptom severity. The overarching goal of the outlined projects is to pre-clincially test and clinically translate this functional imaging approach to comprehensively quantify regional abnormalities in lower extremity skeletal muscle perfusion in the setting of PAD, which could ultimately assist the vascular medicine community by improving non-invasive monitoring of PAD patients, evaluating the efficacy of targeted revascularization procedures, and predicting rates of major adverse limb events after therapeutic interventions.

PI_NAMEs: STACY, MITCHEL R (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Affect;American;Amputation;Anatomy;Angiography;Ankle;Arteries;Atherosclerosis;Autopsy;Award;Blood flow;blood perfusion;Blood Vessels;bone imaging;Breast Microcalcification;calcification;Cessation of life;Chronic;claudication;Clinical;clinical database;clinical efficacy;Communities;Community Medicine;Databases;Defect;design;Detection;detection method;Disease;efficacy evaluation;Evaluation;Event;Family suidae;Fluorine;foot;Functional Imaging;functional status;Funding;Future;Goals;hemodynamics;imaging approach;imaging modality;Imaging Techniques;Impairment;improved;in vivo;Incidence;indexing;individualized medicine;Intervention;Ischemia;Isolated limb perfusion;Knee;Knowledge;Laboratories;Life Style;limb ischemia;limb loss;Limb structure;Lower Extremity;Measures;Methods;Microvascular Dysfunction;Mitochondria;molecular imaging;Monitor;Morphology;Muscle;necrotic tissue;non-healing wounds;non-invasive monitor;novel;Nuclear;Outcome;outcome prediction;Pain;participant enrollment;Patient-Focused Outcomes;Patients;Perfusion;perfusion imaging;Peripheral;Peripheral arterial disease;Persons;porcine model;Positron-Emission Tomography;post intervention;pre-clinical;predict clinical outcome;Procedures;prognostic value;prospective;Quality of life;quantitative imaging;Radioisotopes;radiotracer;Regional Perfusion;Research;response;Rest;revascularization;revascularization surgery;Risk;Severities;single photon emission computed tomography;Skeletal Muscle;Sodium Fluoride;Source;standard of care;Symptoms;Techniques;Testing;Therapeutic Intervention;Time;Tissues;Toes;Translating;treatment response;Ulcer;ultrasound;Vascular Diseases;Vascular remodeling;wound healing;X-Ray Computed Tomography

PROJECT_TITLE: Radiotracer-Based Imaging for Quantitative Assessment of Skeletal Muscle Perfusion in Peripheral Artery Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative: Chemotherapy for cancer can often result in damage to the heart muscle and heart failure. Stimulating a process known as autophagy can protect the heart from this but can, in some cases, also protect the cancer from the chemotherapy. We have developed a technique to image autophagy and will use this to determine whether there are ways to stimulate autophagy that protect the heart and preserve the cancer-killing chemotherapy efficacy.

PI_NAMEs: CHEN, HOWARD H. (contact);SOSNOVIK, DAVID E

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Annexins;Apoptosis;Autophagocytosis;Autophagolysosome;Autophagosome;Biology;Biomedical Engineering;cancer therapy;Cardiac Myocytes;cardioprotection;Cardiotoxicity;Cathepsins;Cell Death;Cell Line;Cells;Chemicals;Chemistry;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;cohort;Combination Drug Therapy;Common Neoplasm;cyanine dye 5;Development;Down-Regulation;Doxorubicin;Exposure to;ferumoxytol;Fluorescence;Fluorochrome;Generations;Genetic;Genetic Models;Heart;heart damage;Heart failure;Human;Image;imaging approach;Immunotherapy;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammation;inhibitor;Injectable;Injections;insight;Intermittent fasting;Investigation;kinetic model;Kinetics;knock-down;Libraries;LIGHT protein;live cell microscopy;Lysosomes;Macrophage;Magnetic nanoparticles;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Microtubule-Associated Proteins;Modeling;Modification;molecular imaging;Monitor;mouse model;Mus;Myocardium;nanoparticle;Nature;Near-infrared optical imaging;neoplastic cell;non-invasive imaging;novel;novel therapeutics;optimal treatments;Organ;Organelles;overexpression;Paper;Penetration;Peptides;Perfusion;Plasmids;Play;polyarginine;preservation;Process;protective effect;Proteins;Publishing;Reporter;response;restoration;Role;Sensitivity and Specificity;Signal Transduction;Sirolimus;Small Interfering RNA;Specificity;Starvation;Structure;superresolution microscopy;Surface;Techniques;Testing;tool;transcription factor;Transfection;Transgenic Mice;Treatment Efficacy;treatment strategy;tumor;Tumor Cell Line;Tyrosine Kinase Inhibitor;Up-Regulation;Vascular blood supply;Work

PROJECT_TITLE: Monitoring Autophagy in the Heart and in Tumors Treated with Potentially Cardiotoxic Chemotherapy

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project narrative: The endocannabinoid system, including type 1 cannabinoid receptors (CB1 receptors), is critical for proper learning and adaptation in neuronal circuits and is dysregulated in a number of psychiatric, neurodegenerative, and motor disorders such as depression, Alzheimer’s disease, and spinocerebellar ataxia. This work will determine cellular mechanisms that regulate presynaptic CB1 receptor activity during learning and demonstrate that activity-dependent changes in CB1 receptors regulates proper synaptic plasticity and learning in the cerebellar circuit.

PI_NAMEs: PUGH, JASON RICHARD (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;Acute;Alzheimer's Disease;Amygdaloid structure;Basal Ganglia;Behavioral;behavioral study;Brain;Cannabinoids;Cell Physiology;Cells;Cerebellum;CNR1 gene;computer studies;Cyclic AMP-Dependent Protein Kinases;Data;Down-Regulation;Electrophysiology (science);Endocannabinoids;endogenous cannabinoid system;environmental enrichment for laboratory animals;Enzymes;Epilepsy;Equilibrium;Excision;experience;Exposure to;eyelid conditioning;Fiber;Future;G protein coupled receptor kinase;Genetic;genetic manipulation;Glutamates;Goals;Hippocampus;Impairment;In Vitro;in vivo;Individual;insight;Knock-in Mouse;Learning;Location;Long-Term Depression;Long-Term Potentiation;Measures;Mediating;Memory;Mental Depression;Mental disorders;Metabolic;Metabolism;Motor;motor disorder;motor learning;Mus;Neurodegenerative Disorders;neuronal circuitry;overexpression;patch clamp;Pattern;pharmacologic;Physiological;postsynaptic;Potassium Channel;presynaptic;Presynaptic Receptors;Presynaptic Terminals;prevent;Probability;Process;Property;Proteins;Purkinje Cells;receptor;Receptor Down-Regulation;receptor downregulation;receptor expression;receptor function;response;Side;Signal Pathway;Slice;SNAP receptor;Spinocerebellar Ataxias;Structure of purkinje fibers;Synapses;Synaptic plasticity;Technology;Testing;trafficking;Training;two photon microscopy;Viral;Work

PROJECT_TITLE: CB1 receptors mediate metaplasticity in the cerebellar circuit

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Identical-by-descent segments inferred from genome-wide data provide information on population history and genetic relatedness that are not sufficiently used in current genetic association approaches. We propose to leverage identical-by-descent segments in the genetic association mapping for Alzheimer’s Disease and related brain imaging endophenotypes, develop efficient statistical methods and implement novel computational algorithms that can be applied to large samples. Our tools and findings will facilitate genetic research and provide novel insights into the genetic architecture of Alzheimer’s Disease.

PI_NAMEs: CHEN, HAN  (contact);ZHI, DEGUI

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithmic Analysis;Alzheimer's Disease;Alzheimer's disease diagnosis;biobank;Brain imaging;brain magnetic resonance imaging;Brain Mapping;causal variant;Clinical;Code;Complex;Computational algorithm;computer framework;Computing Methodologies;Data;data resource;Disease;empowerment;endophenotype;Etiology;flexibility;Genetic;genetic architecture;genetic association;genetic information;Genetic Research;genetic risk factor;genome annotation;genome wide association study;genome-wide;Genomic Segment;Genotype;Haplotypes;Heritability;human disease;identity by descent;Image;Imaging technology;improved;Individual;insight;Joints;large scale data;Maps;Meta-Analysis;Methods;novel;Participant;Pharmaceutical Preparations;Phenotype;Population;Population Heterogeneity;prototype;quantitative imaging;Recording of previous events;Research;Research Personnel;risk variant;Running;Sample Size;Sampling;Signal Transduction;Statistical Methods;Testing;tool;trait

PROJECT_TITLE: Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative We previously identified a novel orphan receptor, Gpr12, as a potent modifier of short-term memory. This study reveals the interacting partners of Gpr12, and the resulting long-term molecular programs that prime and sustain neural activity during short-term memory. More broadly, it helps identify therapeutic targets for reversing short-term memory deficits associated with learning disability, aging, and mental illness.

PI_NAMEs: RAJASETHUPATHY, PRIYA  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Aging;Animal Model;Attention deficit hyperactivity disorder;Automobile Driving;Behavior;Behavioral;Biological Assay;Biology;biomarker identification;Biotin;Brain;Calcium;cell type;Cells;Chromatin;Chromosome Mapping;Chronic;Clinical Data;Cognitive deficits;cognitive performance;Cognitive Therapy;Coupled;Coupling;Data;Disabling;Dissociation;G-Protein-Coupled Receptors;Genes;Genetic Transcription;Genomics;Goals;GPR12 gene;Head;Home;Human;human model;Image;improved;insight;Knock-out;Learning Disabilities;Ligase;Ligation;Link;Mass Spectrum Analysis;Memory;Memory impairment;Mental disorders;Methods;Molecular;molecular dynamics;Mus;neural;Neuroanatomy;Neurosciences;novel;novel therapeutic intervention;Orphan;overexpression;Pathology;Patients;Performance;Physiological;Physiology;Prefrontal Cortex;Process;Prognosis;programs;Property;Proteome;Proteomics;Protocols documentation;Quality of life;Reading;receptor;receptor function;recruit;Regulator Genes;Role;Running;Schizophrenia;Shapes;Short-Term Memory;Signal Transduction;single cell ATAC-seq;Structural defect;Synapses;System;Testing;Thalamic structure;theories;Therapeutic;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;treatment response;two-photon;Variant;Wild Type Mouse;Work

PROJECT_TITLE: Chronic and acute molecular programs enabling working memory


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PUBLIC HEALTH RELEVANCE Heart failure and atrial fibrillation are major public health problems that results from risk factors, including diabetes, obesity, and hypertension. These risk factors cause dysfunction of the left atrium, a chamber of the heart, prior to developing heart failure or atrial fibrillation. This study seeks to identify metabolites and proteins in the blood among individuals with these risk factors that lead to left atrial dysfunction, with the ultimate goal of finding new avenues for prevention and treatment of heart failure and atrial fibrillation.

PI_NAMEs: PATEL, RAVI BHARAT (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: adjudication;Aging;Atherosclerosis Risk in Communities;Atrial Fibrillation;Automobile Driving;Biochemical Pathway;Bioinformatics;bioinformatics network;Biology;Blood;Cardiac;cardiac magnetic resonance imaging;cardiometabolic risk;Cardiopulmonary;cardiovascular health;Cardiovascular system;Clinical;clinical risk;cohort;Communities;comorbidity;Coronary Artery Risk Development in Young Adults Study;Data;Diabetes Mellitus;Echocardiography;EFRAC;ethnic diversity;exercise capacity;Exercise Test;Extracellular Matrix;Fatty Acids;follow-up;Framingham Heart Study;Functional disorder;Genetic;Genetic Variation;Goals;Heart;Heart Atrium;Heart failure;hemodynamics;Hospitalization;Human;Human Genetics;Hypertension;Individual;Inflammation;innovation;insight;Investigation;Joints;Left;Left Atrial Function;Left atrial structure;Leg;Link;Measures;Mechanics;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;Microfilaments;Molecular;molecular marker;Molecular Profiling;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multi-racial;multimodality;Myocardium;National Heart, Lung, and Blood Institute;Nuclear RNA;Obesity;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;Population Heterogeneity;Predisposition;preservation;prevent;Prevention;Proteins;Proteome;proteomic signature;Proteomics;Public Health;public health relevance;Reaction;Regulation;Research Design;Rest;Risk;Risk Factors;Specific qualifier value;Syndrome;therapeutic target;Time;transcriptome sequencing;Validation;Veins;Work

PROJECT_TITLE: Integrated Proteomic and Metabolomic Determinants of Left Atrial Dysfunction

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric

ORG_CITY: COLLEGE STATION

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Pediatric toxoplasmosis is a parasitic disease in immuno-compromised patients with no dose flexible medications available for children at this time. To address the unmet medical need, this proposal seeks to mechanistically develop and characterize an age-appropriate 3D-printed dose-flexible pediatric delivery system of three drugs individually and/or in combination for effective treatment of pediatric toxoplasmosis. It is expected that the quality, stability, palatability (human), pharmacokinetic, and pharmacodynamic (safety and efficacy) profiles of dose-flexible pediatric delivery systems will meet FDA and USP requirements for eventual deployment in hospitals for pediatric use.

PI_NAMEs: KHAN, MANSOOR A (contact);RAHMAN, ZIYAUR

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: 3D Print;Address;Adolescent;Adult;Adverse event;Age;age group;Animal Model;appropriate dose;Biological Availability;Centers for Disease Control and Prevention (U.S.);Child;Childhood;Clindamycin;Clinical;Combined Modality Therapy;comparative;congenital infection;cost;Data;Development;Diclofenac;Disease;dosage;Dosage Forms;Dose;Drug Combinations;Drug Delivery Systems;Drug Formulations;Drug Kinetics;Drug usage;effective therapy;efficacy testing;Environment;Evaluation;experience;fabrication;Failure;FDA approved;flexibility;foodborne;Formulation;Hospitals;Human;Immunocompromised Host;improved;Incidence;Individual;innovation;isoniazid;Knowledge;Leucovorin;Leucovorin Calcium;Life;Liquid substance;Lopinavir;manufacture;Manufactured form;Medical;Medicine;melting;Methods;mouse model;National Institute of Child Health and Human Development;Newborn Infant;novel;Overdose reduction;Paper;Parasites;Parasitic Diseases;Patient Compliance;Patients;Pediatric Hospitals;pediatric patients;pediatrician;Pharmaceutical Preparations;Pharmacists;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacy facility;Physicians;point of care;Population;porcine model;Porosity;Preparation;prevent;Price;Printing;Production;Publishing;Pyrimethamine;Reporting;Resources;Safety;safety testing;Scientific Advances and Accomplishments;Scientist;Solid;South Texas;Sulfadiazine;System;Tablets;Taste Perception;Therapeutic;Time;Titrations;Tongue;Toxic effect;Toxoplasma gondii;Toxoplasmosis;Treatment Cost;United States;United States National Institutes of Health;virtual;Visual;Work

PROJECT_TITLE: Pediatric toxoplasmosis: Addressing unmet medical need with 3D printed dose flexible delivery systems of pyrimethamine, sulphadiazine and leucovorin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The overarching goal of this project is to improve the reproducibility of quantitative MRI and, consequently, the objectivity of radiological readings. The project will also improve the comparability of different scans, which is much needed in the age of large multi-center studies, artificial intelligence, and precision medicine. Further, we will enhance MRI’s sensitivity and specificity to pathologies, in particular to the different pathologies in multiple sclerosis, which will improve therapeutic planning.

PI_NAMEs: ASSLAENDER, JAKOB  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Age;Aging;Alzheimer's Disease;Artificial Intelligence;Atrophic;Axon;Biological;Biological Markers;biophysical model;biophysical properties;Biophysics;Brain;Brain imaging;brain tissue;Characteristics;Chronic;Clinical;clinical imaging;clinical outcome measures;Clinical Trials;Communication;comparative;Complex;Data;Dementia;Dependence;design;Development;disability;Disease;effectiveness evaluation;Engineering;Exhibits;Formulation;Goals;gray matter;Heart;Hybrids;Image;image reconstruction;improved;in vivo;in vivo imaging;Individual;Inflammation;Iron;Knowledge;Lesion;Literature;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Methodology;Methods;Modeling;Multicenter Studies;Multiple Sclerosis;Myelin;Nature;Nerve Degeneration;neurodevelopment;Neuroglia;neuroimaging;Neurologic;Neuronal Plasticity;Organ;Outcome;Parameter Estimation;Pathology;Physics;Physiologic pulse;Play;precision medicine;Process;radiologist;Radiology Specialty;Reference Values;Relapse;Relaxation;Reporting;Reproducibility;Research;Resolution;Role;Rotation;routine imaging;Sampling;Scanning;Sensitivity and Specificity;Signal Transduction;Solid;Specificity;Testing;Therapeutic;Time;Tissues;tool;Training;Variant;Water;white matter;Work

PROJECT_TITLE: Quantification of Multi-Compartment T1 Relaxation and Magnetization Transfer in Biological Tissue: From Biophysics to Biomarkers for Multiple Sclerosis

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research will be the first longitudinal study to examine the effects of prenatal and postnatal exposure to air pollutants on the gut microbiome and fecal metabolome, and on subsequent brain measures and neurodevelopmental outcomes. Study findings will address a critical gap in our current understanding of the harmful effects of air pollution in early life, particularly alterations in gut bacterial species and fecal metabolic pathways that contribute to altered brain development and poorer neurodevelopmental outcomes.

PI_NAMEs: ALDERETE, TANYA LYNN (contact);PETERSON, BRADLEY S

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Adult;Affect;Age Months;Air Pollutants;Air Pollution;Amino Acids;Animal Model;Anxiety;Archives;Attention deficit hyperactivity disorder;Attenuated;autism spectrum disorder;Bacteroides;Behavioral;Bile Acids;Birth;Blood flow;Brain;brain magnetic resonance imaging;brain tissue;Child;Childhood;Clostridium;Cognition;Cognitive;cognitive ability;cognitive development;cognitive performance;cognitive testing;cohort;County;Data;Development;Developmental Delay Disorders;DNA sequencing;early life exposure;economic cost;Emotional;Environmental Exposure;Exposure to;fecal metabolome;Feces;feeding;follow-up;frontal lobe;Funding;Growth;gut bacteria;gut microbiome;Health;Hippocampus;Human;Impairment;infancy;Infant;infant gut microbiome;Inflammation;Intervention;Knowledge;knowledge base;Language;Lateral;Latino;Learning Disabilities;Life;Link;Lipid Peroxidation;Lipids;Literature;Longitudinal Studies;Los Angeles;Magnetic Resonance Imaging;Maternal Health;Measures;Mediating;Mediator;Mental Depression;Mental disorders;Metabolic Pathway;metabolic profile;metabolomics;Metagenomics;microbial;Microglia;mother nutrition;Mothers;Motor;multidisciplinary;multimodality;myelination;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;novel;Nutritional;Outcome;Oxidative Stress;Parietal Lobe;Pathway interactions;Physiology;Population;postnatal;postnatal period;prenatal;prenatal exposure;prevent;Production;prospective;Research;Research Personnel;Rest;Role;School-Age Population;stool sample;Structure;Temporal Lobe;Testing;underserved community;United States National Institutes of Health;Variant;Volatile Fatty Acids;white matter

PROJECT_TITLE: Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Stroke, seizure, and brain trauma cause acute injury to neurons through excitatory cell stress, yet few treatment options are available. This project investigates basic cellular and molecular mechanisms that confer a pro-survival advantage during neuronal cell stress, and will identify potential new therapeutic targets for treating CNS injuries.

PI_NAMEs: HALPAIN, SHELLEY L (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acceleration;Actins;Acute;Address;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Biochemical;Biochemistry;Biological;Brain Hypoxia-Ischemia;Calcium;Cause of Death;Cell Death;Cell-Free System;Cells;Cellular biology;Cellular Stress;central nervous system injury;cerebroprotection;Chronic;chronic traumatic encephalopathy;Cytoskeleton;Dendrites;Dendritic Spines;depolymerization;Emergency treatment;Endoplasmic Reticulum;Etiology;Excision;excitotoxicity;experimental study;F-Actin;Family member;Filament;formin-2;Foundations;Future;Generations;Goals;In Vitro;in vivo;Individual;Injury;innovation;Ischemia;Long term disability;Mediating;Modeling;Molecular;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;neuronal cell body;Neuronal Injury;neuronal survival;Neurons;new therapeutic target;Organelles;Osmoregulation;Osmosis;overexpression;Pathway interactions;Patients;polymerization;Polymers;Positioning Attribute;preclinical study;preservation;Public Health;Reactive Oxygen Species;Recovery;Research Personnel;resilience;Resistance;response;Role;Seizures;Series;Site;Solid;Stimulus;Stress;Stroke;Swelling;Synapses;Testing;therapeutic target;Traumatic Brain Injury

PROJECT_TITLE: Pro-Survival Responses to Neurocellular Stress


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses how maternal obesity and exercise impacts neuronal development. It is expected to identify critical signaling mechanisms by which neurotropic factors, such as BDNF are interdependent on other neurotrophic factors to regulate synaptic development; disruption of which has been associated with Intellectual Disability, Major Depressive Disorder, Schizophrenia, Autism Spectrum Disorder, Rett Syndrome and Alzheimer Disease as well as other neurodevelopmental disorders. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to elucidating how obesity and maternal behavior impacts development and developing targeted approaches for the prevention and treatment of obesity and mental health disorders, such as Autism spectrum disorder, depression, anxiety and cognitive function.

PI_NAMEs: WAYMAN, GARY ALLEN (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;anti-depressive agents;Anxiety;APLN gene;autism spectrum disorder;Behavioral;brain health;Brain-Derived Neurotrophic Factor;Cognition;Cognition Disorders;Cognitive;cognitive function;Cues;Data;Development;disability;Embryo;Emotional;Emotional disorder;Environment;Exercise;Glutamates;Goals;high risk;Hippocampal Formation;Hippocampus;Human;Impairment;in utero;In Vitro;in vivo;innovation;Insulin;Insulin Resistance;insulin sensitivity;Intellectual functioning disability;Knowledge;Lead;Link;Major Depressive Disorder;Maternal Behavior;maternal obesity;Mediating;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolic hormone;Mission;Molecular;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;neuron development;Neurons;neuroprotection;neuropsychiatric disorder;neurotrophic factor;neurotropic;novel;obese mothers;Obesity;obesity development;obesity in children;obesity treatment;offspring;Outcome;Pathway interactions;Persons;Prevention approach;Public Health;receptor;Regulation;Research;resilience;Rett Syndrome;Risk;Schizophrenia;Signal Transduction;Synapses;synaptogenesis;Testing;Therapeutic;Time;United States National Institutes of Health

PROJECT_TITLE: Metabolic hormones and their involvement in the positive and negative effects of maternal exercise and obesity on synaptic development


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma is the 3rd deadliest cancer in the US with only 3% of patients surviving beyond 5 years after the cancer has spread. Less than 25% of patients are eligible for surgery, and the effects of chemotherapy and immunotherapy are limited by various barriers in the tumor immediate environment. This project harnesses a light-activated priming treatment to restore the effects of chemotherapy, improve the immune system’s ability to eliminate the tumor, and prolong survival rates.

PI_NAMEs: OBAID, GIRGIS  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: anti-PD-L1 antibodies;Antibodies;Antitumor Response;Behavior;Binding;Biochemical;Cancer Etiology;Cell Separation;Cessation of life;checkpoint inhibition;checkpoint receptors;checkpoint therapy;chemotherapy;Clinical;Clinical Management;Combination Drug Therapy;Complex;Deposition;Diagnosis;disorder control;Disseminated Malignant Neoplasm;Distant Metastasis;Dose;Dose Limiting;Drug Delivery Systems;Eligibility Determination;Engineering;Environment;Epidermal Growth Factor Receptor;Exhibits;Extracellular Matrix;Failure;Fluorescence;gemcitabine;Genetically Engineered Mouse;Heterogeneity;Hydrophobicity;image guided;immune checkpoint;immune checkpoint blockade;Immune system;Immuno-Chemotherapy;immunogenic cell death;immunological status;Immunologics;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;innovation;Light;Liposomes;Localized Disease;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modality;Modeling;molecular imaging;Molecular Weight;Monoclonal Antibodies;mouse model;Mus;nanomedicine;Neoplasm Metastasis;Operative Surgical Procedures;Optics;Outcome;overexpression;Paclitaxel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;pembrolizumab;Phase II Clinical Trials;Prognosis;programmed cell death ligand 1;Protocols documentation;Publishing;Quality of life;Rattus;Reaction;receptor;Regimen;remediation;Resectable;response;Solid Neoplasm;spatiotemporal;Specificity;success;Survival Rate;Systemic disease;T cell infiltration;T-cell inflamed;T-Lymphocyte;Testing;Therapeutic;three-dimensional modeling;Tissues;tool;Toxic effect;tumor;tumor growth;tumor specificity;Tumor Tissue;tumor-immune system interactions;Work;Xenograft Model

PROJECT_TITLE: Molecular Imaging Guidance for Potentiating Chemoimmunotherapy in Pancreatic Cancer using Photodynamic Priming

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  The proposed research is directly relevant to public health because it will quantify and analyze novel genes for the study of non-alcoholic fatty liver disease. Because this project makes use of translational methods in laboratory-engineered human liver tissue with direct relevance to development of therapeutic targets for a widely prevalent liver disease, this project is directly relevant to development of human therapies to the NIH mission to enhance health, lengthen life, and reduce the burdens of illness and disability.

PI_NAMEs: MATTIS, ARAS NIKODEMAS (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Affect;Apoptosis;Applications Grants;biological adaptation to stress;Biological Assay;burden of illness;California;CASP3 gene;Cell Line;Cirrhosis;clinical translation;Complex;CRISPR interference;CRISPR/Cas technology;cytokine;Development;Diet;disability;Disease;disease model;Disease Pathway;disease phenotype;Dose;Doxycycline;endoplasmic reticulum stress;Environment;exome sequencing;exosome;experimental study;Family;Fibrosis;gain of function;Genes;Goals;Grant;Health;Hepatic;Hepatocyte;Human;Human Engineering;In Vitro;in vitro Model;induced pluripotent stem cell;Inflammasome;Inflammatory;Insulin Resistance;Intracellular Accumulation of Lipids;intrahepatic;Kinetics;Knock-out;Laboratories;Life;Lipids;Liver;Liver diseases;liver inflammation;loss of function;Manuscripts;MAPK9 gene;Measures;Medical Research;Methods;Mission;Modeling;mouse model;mutant;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity Epidemic;Oleates;Oxidative Stress;Palmitates;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Phosphorylation;Population;Predisposition;Preparation;Primary carcinoma of the liver cells;Process;Proliferating;Public Health;repaired;Research;Research Project Grants;Risk;RNA Splicing;San Francisco;Scientist;Signal Transduction;Single Nucleotide Polymorphism;Study models;System;Testing;therapeutic development;therapeutic target;Tissues;Titrations;transcriptome sequencing;United States National Institutes of Health;Universities;Variant;vector;Western Blotting;XBP1 gene

PROJECT_TITLE: Modeling and Characterization of NAFLD Phenotypes in a Severely Affected Family

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hypertension;Prevention;Primary Health Care

ORG_CITY: PORTLAND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE If detected early, hypertension (HTN) is treatable; yet, HTN screening rates are low and inequitable in Sub- Saharan Africa (SSA) leaving many people with undiagnosed HTN, especially in urban areas. Thus, it is a high priority to determine the acceptability, effectiveness, and sustainability of strategies to increase rates of BP screening and connections to care in SSA. The overarching goals of this project are to: (1) Adapt evidence- based implementation strategies – called community vital signs (CVS) strategies – to support BP screening and connections to care; (2) Implement the CVS strategies and assess acceptability, test their effectiveness in improving rates of BP screening and connections to care, and understand facilitators and barriers to their sustainability.

PI_NAMEs: DEVOE, JENNIFER E (contact);EZEANOLUE, ECHEZONA EDOZIE

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: 18 year old;Address;Adoption;Adult;Affect;Africa;Africa South of the Sahara;arm;Awareness;Blood Pressure;Cardiovascular Diseases;care systems;Caring;Chronic Disease;Cities;Clinic;Clinical;Clinical effectiveness;cluster randomized design;Communities;community clinic;Community Health;cost effectiveness;Country;Coupled;Data;Data Linkages;data sharing;Detection;Diagnosis;Diastolic blood pressure;digital technology;Early Diagnosis;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;Enabling Factors;Equity;evidence base;Evidence based intervention;Goals;health care availability;Health care facility;health care settings;Health Insurance;Healthcare;HIV;Hypertension;hypertension control;hypertension treatment;implementation evaluation;implementation framework;implementation outcomes;Implementation readiness;implementation science;implementation strategy;improved;Inequity;Infrastructure;innovation;Intervention;Intervention Studies;low and middle-income countries;Maintenance;meetings;Methods;mHealth;Modeling;modifiable risk;Morbidity - disease rate;mortality;Nigeria;Nigerian;Nurses;Outcome;Participant;Persons;Pharmaceutical Preparations;Phase;practice-based research network;Pregnant Women;Preparation;Prevalence;prevent;Preventive care;Primary Care;primary care clinic;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resources;Risk Factors;scale up;screening;screening program;Self Management;Site;Stroke;Testing;Text Messaging;Training;uptake;urban area;voucher;Work

PROJECT_TITLE: Community Vital Signs (CVS): An integrated community-based approach to identify undiagnosed hypertension in Nigeria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (50)]