ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Interventions to prevent and manage chronic illness that can be readily implemented into clinical practice are essential to improving the health of populations. The purpose of this program is to prepare nurse scientists in community-engaged intervention mapping to advance the sciences of intervention development and translation.

PI_NAMEs: KNEIPP, SHAWN MARIE;SANTACROCE, SHEILA JUDGE (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Chronic Disease;Intervention;prevent

PROJECT_TITLE: Interventions for Preventing and Managing Chronic Illness


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative  Pediatric healthcare inequities in the United States remain persistent and pervasive; patient-provider communication and the frequent mismatch between a family’s skills and resources and the healthcare system’s demands (such as health literacy and system navigation) are important drivers of these inequities, yet few interventions exist to address them. This project will test the effectiveness of the Family Bridge Program, a novel intervention combining principles of effective patient navigation and communication coaching into a brief and targeted inpatient program, on family-centered outcomes including system navigation ability, hospital-to- home transition, comprehension, and observed communication quality. If found effective, the Family Bridge Program would provide a scalable model for addressing inequities in healthcare experiences and outcomes for families of low-income children of color, including those with limited English proficiency.

PI_NAMEs: LION, KATHERINE CASEY (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Acute Pain;Address;Adverse event;Advocacy;Asthma;Attention;barrier to care;bridge program;care coordination;Caregivers;Caring;Child;Child health care;children of color;Clinical;Collaborations;Communication;comparison control;Comprehension;cost;cultural competence;design;Diagnosis;Disease;Disparate;Education;effectiveness testing;effectiveness trial;Elements;Emotional;Enrollment;experience;Family;flexibility;follow-up;food insecurity;Future;Health;health care disparity;health inequalities;health literacy;Health Personnel;Health system;Healthcare;Healthcare Systems;Heterogeneity;Home;Hospitalization;Hospitalized Child;Hospitals;Household;Human;Immigrant;improved;Inequity;innovation;Inpatients;interest;Intervention;leukemia;Limited English Proficiency;Link;Logistics;Low income;Low Income Population;lower income families;Maps;Mediating;Medical;minority children;Modeling;novel;Nurses;Outcome;outcome disparities;Pain management;Parents;Participant;patient navigation;patient navigator;patient-clinician communication;Patients;perceived stress;Persons;pilot test;Play;Population Heterogeneity;preference;primary outcome;Process;programs;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research Methodology;Resources;Role;screening;secondary outcome;Severity of illness;Site;skills;social;Stress;Subgroup;System;Telephone;Testing;Time;Training;treatment as usual;treatment effect;Trust;United States;Visit;Work;Writing

PROJECT_TITLE: The Family Bridge Program to Address Communication and Navigation-Related Inequities for Minority Children and Families: A Randomized Controlled Trial

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Family violence imposes substantial and long-lasting burdens on children, particularly those in heavily policed and incarcerated communities. But little is known about how objective and subjective experiences of institutional contact in such communities may affect family violence incidence, disclosure, help-seeking, or consequences. The proposed project will advance the study of children’s exposure to family violence in the contemporary United States by collecting primary qualitative and survey data and applying inductive and latent variable methods for formative analysis. psychometric validation, and hypothesis testing.

PI_NAMEs: MCKAY, TASSELI  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescent;Affect;American;analytical method;authority;career;Chicago;Child;Child Abuse and Neglect;Child Development;Child Health;Child Welfare;Childhood;cognitive interview;cohort;Cohort Studies;Communities;Data;Dedications;Development;Dimensions;Disclosure;Environment;Etiology;Event;experience;Exposure to;Faculty;Family;Family member;Family Process;Family Study;Family Violence;Feedback;Foundations;Goals;Growth;Health;health care service;health science research;help-seeking behavior;Human Development;Imprisonment;Incidence;Individual;innovation;insight;Institution;Intervention;Interview;Law Enforcement;Legal system;Link;Longitudinal Surveys;maltreatment;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;model development;Modeling;National Institute of Child Health and Human Development;Neighborhoods;novel;Outcome;Parents;Participant;Pathway interactions;Personal Satisfaction;Persons;Phase;Police;Positioning Attribute;Poverty;Principal Investigator;probation;Psychometrics;public health intervention;Public Policy;Punishment;Reaction;Reporting;Research;Review Literature;Risk;Role;Scientist;secondary analysis;Secure;service utilization;Shapes;skills;social determinants;social service provider;sound;Structural Racism;Support System;Surveys;tenure track;Testing;Time;tool;Training;trait;transition to adulthood;United States;Validation;Violence;violence exposure;vulnerable community;Work;Youth

PROJECT_TITLE: Institutional Contact and Family Violence in an Era of Mass Incarceration

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Myogenic direct reprogramming from non-muscle somatic cells has become an important strategy to produce abundant, patient-specific, and disease-specific human myogenic cells, but applications of these cells are hampered by low reprogramming efficiency and their immature nature. In this project, we will develop a high- throughput screening platform with a simple, low-cost, and physiologically relevant readout to effectively discover efficient myogenic reprogramming technologies. Successful accomplishment of this project will result in new technologies to generate directly reprogrammed human myogenic cells exhibiting more similarities to true myogenic cells for therapeutic applications and disease modeling.

PI_NAMEs: SHEN, WEI  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Aging;aging related;Biological;Cell model;Cells;Chromatin;cost;differential expression;direct application;Disease;disease model;Engineering;Enhancers;Epigenetic Process;Exhibits;Future;Genes;Genetic Transcription;genome-wide analysis;Goals;Heterogeneity;high throughput screening;Human;human induced pluripotent stem cells;improved;matrigel;MicroRNAs;Modeling;Molecular;Muscle;Muscle Cells;Muscle Fibers;Myopathy;Nature;new technology;novel;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Process;rational design;Reproducibility;Risk;Somatic Cell;Surface;Technology;Teratoma;Testing;Therapeutic;three dimensional cell culture;transcription factor;transdifferentiation

PROJECT_TITLE: Enhance myogenic transdifferentiation efficiency using engineering approaches

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The p53 tumor suppressor is a DNA damage/stress response protein that functions as a transcription factor to regulate a large repertoire of genes that prevent proliferation of damaged cells via initiation of cell cycle arrest and senescent programs or via apoptosis and other mechanisms of cell death. We have defined a pan-tissue p53 transcriptional signature that includes seven genes, three of which have been implicated in human cancers and have unique properties as a cell surface receptor that induces apoptosis (Eda2r), as a potential novel p53 inhibitor (Gtse1), and as an error prone DNA polymerase (Polκ). In this proposal, we will directly evaluate the functional contributions of these genes to p53-dependent cellular outcomes and tumor suppression in vivo, and comprehensively evaluate the p53 transcriptional response at single cell resolution.

PI_NAMEs: LOZANO, GUILLERMINA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Apoptosis;Apoptotic;Atrophic;Binding;biological adaptation to stress;Biological Models;cancer genomics;Cell Cycle;Cell Cycle Arrest;Cell Death;cell injury;Cell Nucleus;Cell Surface Receptors;Cell Survival;Cells;Colorectal Cancer;Cytoplasmic Protein;Data;Defect;Dependence;Development;DNA Damage;DNA Replication Damage;DNA-Directed DNA Polymerase;Duct (organ) structure;Ensure;Family;Gene Activation;Gene Expression Profile;Genes;Genetic Transcription;genomic data;Glioblastoma;GTSE1 gene;Heart;Hemangiosarcoma;Homeostasis;Human;in vivo;Individual;Induction of Apoptosis;Inflammation;inhibitor;Intestines;Kidney;Knockout Mice;Knowledge;KRASG12D;male;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;MDM2 gene;member;Membrane;Metaplasia;migration;Modeling;Molecular;Morphology;Mus;mutant;Mutate;Mutation;Nature;novel;novel therapeutic intervention;Outcome;Ovary;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathology;Pathway interactions;Phenocopy;Physiological;Polymerase;preservation;prevent;Process;programs;Proliferating;Property;protein function;Radiation;receptor;Regulation;Resolution;response;Role;S phase;senescence;Sequence Analysis;single cell analysis;Specificity;Spermatogenesis;Therapeutic;Tissues;TNF gene;TP53 gene;transcription factor;tumor;Tumor Suppression;tumorigenesis

PROJECT_TITLE: A Pathway of Tumor Suppression

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The proposed investigation extends for a 5-year period our longitudinal study to (1) maintain and expand the existing cohort to serve as a platform for independently funded studies and other collaborative research on HIV-related outcomes, and (2) determine whether HIV infection, chronic cocaine use, and duration/type of antiretroviral medication use are related to hidden heart disease and other conditions.

PI_NAMEs: LAI, SHENGHAN  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;Address;Age;Aging;Anti-Retroviral Agents;antiretroviral therapy;Area;Atherosclerosis;Baltimore;Basic Science;Behavioral Research;Biological Markers;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Chronic;Clinical;Clinical Research;Cocaine;cocaine use;Cocaine Users;cognitive function;cohort;Cohort Studies;Collaborations;comorbidity;Coronary Arteriosclerosis;coronary computed tomography angiography;coronary plaque;Coronary Stenosis;Creativeness;Development;Diameter;Drug abuse;Drug usage;Exposure to;Fostering;Funding;Future;Goals;Grant;Heart Diseases;HIV;HIV Infections;HIV/AIDS;Homocysteine;Impaired cognition;Individual;Infection;Investigation;Investigator-Initiated Research;Length;Long-Term Effects;Longitudinal Studies;Maryland;Medical;middle age;mortality;multidisciplinary;National Institute of Drug Abuse;older adult;Older Population;Outcome;Participant;Persons;Pharmaceutical Preparations;platform-independent;Population;Prevention;Research;Research Personnel;Research Priority;Resources;Risk Factors;Substance abuse problem;Substance Use Disorder;success;telomere;Telomere Shortening;Testing;Troponin T;United States National Institutes of Health;young adult

PROJECT_TITLE: Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Synthetic chemistry provides access to molecules important to human health through the assembly of chemical building blocks into drugs and molecular probes. This proposal outlines a program designed to provide new iridium-catalyzed methods for the synthesis of alkylboronic esters by direct sp3 C-H borylation. A central feature of this program is the application of catalyst- controlled selectivity to upgrade abundant chemical feedstocks into valuable, complex products including unnatural amino acid derivatives, linker molecules, and cyclic boronic esters.

PI_NAMEs: SCHLEY, NATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Iridium complexes for the activation and functionalization of carbon hydrogen-bonds in unactivated substrates

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Behavioral and Social Science;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This study examines the precise timing, nature, and modifiable determinants of spontaneous change in cigarette smoking during pregnancy to identify novel mechanisms that disrupt addictive processes. To overcome methodologic limitations of prior studies, we conduct within-person, within-pregnancy, and between- pregnancy analyses of existing quantitative and qualitative data derived from multiple longitudinal prenatal tobacco exposure cohorts.

PI_NAMEs: MASSEY, SUENA HUANG (contact)

PROJECT_TERMS: Acceleration;addiction;Adoption;Attenuated;Awareness;behavior change;cardiovascular disorder prevention;caregiving;Categories;Characteristics;Child;child bearing;Child Rearing;cigarette smoking;Clinical;Code;Cognition;Cognitive;cohort;Complex;Conceptions;Data;Data Analyses;data integration;Data Set;design;Development;Developmental Process;Drug abuse;Drug Exposure;Drug usage;Epidemiologist;Epidemiology;Event;experience;Experimental Designs;Failure;fetal tobacco exposure;financial incentive;Foundations;Future;Goals;improved;Individual;innovation;insight;Interruption;Intervention;Interview;Investigation;Investments;Knowledge;life span;Link;Measures;Mediator;Methodology;Mothers;Multiple Pregnancy;National Institute of Drug Abuse;Nature;novel;offspring;Outcome;Parents;Pathway interactions;Pattern;person centered;Persons;Pharmaceutical Preparations;precision medicine;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal intervention;Prevention;Process;protective effect;Psychiatrist;psychosocial;Public Health;Risk;Role;Sampling;Scientist;Second Pregnancy Trimester;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking during pregnancy;social;Social Processes;Specific qualifier value;Substance abuse problem;substance use;Testing;therapy design;Time;Tobacco;tool;unborn child;Woman;Work

PROJECT_TITLE: Elucidating Mechanisms of Pregnancy's Protective Effect on Drug Abuse Using Integrated Data Analysis

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is expected to develop in vivo MR to assess tendon matrix structural and metabolic properties. This work will use both NMR studies of tissue explants and MRI studies in phantoms, tissue explants, and humans, to establish MR chemical shift imaging markers of tissue damage and metabolism. We will also establish relationships between acute bouts of tendon loading and chemical shift signatures of cell metabolic response. We aim to optimize MRI acquisition and analysis methods and establish a robust in vivo approach for characterizing matrix structural and functional differences between healthy tendon and tendinopathy.

PI_NAMEs: REITER, DAVID A (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: achilles tendon;Activities of Daily Living;Acute;Affect;anaerobic glycolysis;Anatomy;Animal Experiments;Animals;Biological;Biological Process;Biomechanics;Cells;Chemical Shift Imaging;Chemicals;Chronic;clinical decision-making;Complex;Contralateral;Coupled;detection sensitivity;Development;Dialysis procedure;effective therapy;Energy Metabolism;Evaluation;Exercise;Exhibits;experimental study;Extracellular Matrix;Frequencies;Functional Imaging;Glycolysis;healing;Homeostasis;Human;human imaging;Image;imaging biomarker;imaging study;improved;in vivo;in vivo evaluation;indexing;Individual;Joints;Lower Extremity;Magic;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Maps;Measurement;Measures;mechanical properties;Mechanics;Metabolic;metabolic abnormality assessment;Metabolism;Methodology;Methods;Molecular;Musculoskeletal;novel;Oxygen Consumption;Pain;Pathogenesis;Pathologic;Patients;Production;Property;Rattus;repaired;Research;Resolution;response;Sampling;simulation;Specialist;Structure;Tendinopathy;Tendon structure;Time;Tissues;Translating;treatment strategy;Upper Extremity;Work

PROJECT_TITLE: MRI of Tendon Structure and Metabolism

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The identification of distinct cell-types throughout the basal ganglia has been essential in advancing our understanding of network function and improving neurological therapies. This proposal seeks to understand the cellular mechanisms by which cell-type specific interventions in the external segment of the globus pallidus (GPe) restore basal ganglia function in mouse models of Parkinson’s disease to provide long-lasting therapeutic effects.

PI_NAMEs: GITTIS, ARYN HILARY (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Advanced Development;Arousal;Basal Ganglia;Behavioral;Brain;Cell Nucleus;cell type;Collaborations;Deep Brain Stimulation;Disease;Dopamine;Electrophysiology (science);Functional disorder;Globus Pallidus;Goals;Homeobox;Hour;Human;improved;in vivo;innovation;Intervention;Link;long term recovery;Long-Term Effects;Maps;Masks;Motor;motor symptom;mouse model;Mus;neural circuit;Neural Pathways;Neurologic;Neuronal Dysfunction;Neurons;Neurosurgeon;non-motor symptom;optogenetics;Parkinson Disease;Parkinsonian Disorders;parkinsonian rodent;Parvalbumins;Pathologic;Pattern;Physiological;Physiology;Preclinical Testing;Protocols documentation;repaired;Specificity;Synapses;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic evaluation;Translating;Treatment Efficacy

PROJECT_TITLE: Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s Disease


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: NATIONAL DISEASE RESEARCH INTERCHANGE

PHR: Program Director/Principal Investigator (Bell, Thomas, J.): Project Narrative: The first major public resource studying somatic mosaicism in tissues from all development layers in the human body will be available to scientists upon the completion of the Somatic Mosaicism across Human Tissues (SMaHT) network project. To enable this groundbreaking effort, the SMaHT Tissue Procurement Center (TPC) will provide all human tissue samples to the SMaHT network centers for experimental analysis. This proposal supports the developmental and implementation of the SMaHT TPC. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BELL, THOMAS J (contact)

PROGRAM_OFFICER_NAME: SENTHIL, GEETHA

PROJECT_TERMS: Address;Authorization documentation;Autopsy;biobank;Biology;Board Certification;Body System;Brain;Cells;Clinical;Collection;Communities;Data;Data Analyses;design;Development;Diagnosis;Disease;DNA Sequence Alteration;empowerment;equity, diversity, and inclusion;Ethical Analysis;ethical, legal, and social implication;Ethnic Origin;Evaluation;experience;experimental analysis;Factor Analysis;Faith;Family;Focus Groups;Gene Expression;Generations;Genetic Variation;Genotype;Grant;Health equity research;Human;Human body;human disease;human tissue;Image;Individual;Infrastructure;insight;Institution;Intention;Interview;Investigation;Lead;Maryland;Methodology;Mosaicism;novel strategies;operation;Organ;Organ Procurements;Pathologic;Pathology;Pediatric Hospitals;Principal Investigator;Procedures;Process;programs;Psychologist;Quality Control;Race;Recovery;Reliability of Results;Reporting;Reproducibility of Results;Research;Research Design;Research Personnel;Resources;Sampling;Scientist;social culture;Somatic Mutation;Spinal Cord;Structure;success;Technical Expertise;technology development;Tissue Banks;Tissue Donations;Tissue imaging;Tissue Procurements;Tissue Sample;Tissues;tool development;Training;United States National Institutes of Health;Universities;whole slide imaging

PROJECT_TITLE: Tissue Procurement Center (TPC) Supporting the Somatic Mosaicism across Human Tissues (SMaHT) Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-D(70)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Hematology;Orphan Drug;Pain Research;Precision Medicine;Rare Diseases;Sickle Cell Disease

ORG_CITY: CLEVELAND

ORG_NAME: BIOCHIP LABS, INC.

ORG_STATE: OH

PHR: PROJECT NARRATIVE Deformability and non-adherence are the most intrinsic biorheological properties of red blood cells (RBCs), as they play a critical role in modulating RBC perfusion through the microvasculature. OcclusionChip is a novel standardized in vitro microfluidic assay to measure microvascular occlusion mediated by red blood cells in a wide range of clinical conditions. The goal of this project is to establish the manufacturability, analytical validation, and clinical utility of the OcclusionChip in providing comprehensive functional characterization of red cell biorheological properties and assessment of patient-specific response to emerging targeted and curative therapies in sickle cell disease.

PI_NAMEs: FEDERICI, CHIARA  (contact);GURKAN, UMUT A.

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Abnormal Red Blood Cell;acute chest syndrome;Adhesiveness;Adhesives;Antisickling Agents;autosome;Biological Assay;Blood capillaries;Blood Cell Count;Blood specimen;Blood Tests;Blood Vessels;capillary bed;Cell Adhesion;Clinical;clinical efficacy;Collaborations;commercialization;comorbidity;companion diagnostics;Contracts;conventional therapy;cost estimate;curative treatments;design;Devices;diagnostic assay;digital;Disease;drug candidate;Drug Screening;Erythrocytes;fabrication;Functional disorder;gene therapy;Genetic;Goals;Guidelines;Hematological Disease;Hemoglobin;high volume manufacturing;human subject;improved;In Vitro;indexing;Individual;Industrialization;Inherited;Legal patent;manufacturability;manufacture;Manufacturer;manufacturing process;Marketing;Measures;Mediating;Medical Care Costs;Methods;microdevice;Microfluidic Microchips;microfluidic technology;Microfluidics;Morbidity - disease rate;Morphology;mortality;novel;Optics;Organ failure;Pain;Pathologic;patient response;Perfusion;Pharmaceutical Preparations;Pharmacologic Substance;Phase;photonics;Physiologic arteriovenous anastomosis;Play;Population;Procedures;Property;Publishing;Quality Control;Role;Sickle Cell Anemia;sickling;Side;Small Business Technology Transfer Research;Standardization;Stroke;success;Surface;targeted agent;targeted treatment;Testing;Translating;Treatment Efficacy;treatment response;United States Food and Drug Administration;Validation

PROJECT_TITLE: Microfluidic Technology for Concurrent Assessment of Red Blood Cell Adhesion and Deformability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Estrogen;Genetics;Lung

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: RELEVANCE (See instructions): Ozone is a ubiquitous urban air pollutant that causes significant cardiopulmonary morbidity in healthy and  susceptible individuals, including children and the elderly. Our studies are focused on elucidating the role of  estrogen receptor signaling in macrophage inflammatory responses to ozone which are known to be  important in tissue injury and disease pathogenesis. Results may lead to the development of novel  strategies for mitigating disease burden and will better inform regulatory guidelines.

PI_NAMEs: SMITH, LEY C (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Air Pollutants;Anti-Inflammatory Agents;Antioxidants;Automobile Driving;Award;Bioenergetics;Bioinformatics;Biology;burden of illness;Cardiopulmonary;Cell membrane;Child;Classification;Connecticut;cytotoxic;Data;Development;differential expression;Disease;Down-Regulation;Elderly;Environment;Environmental Exposure;Equilibrium;ESR1 gene;Estrogen Nuclear Receptor;Estrogen Receptors;Estrogens;Exposure to;Failure;fatty acid oxidation;Flow Cytometry;Funding;Genes;Glycolysis;Guidelines;Human;Impairment;Individual;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Injury;Institution;Instruction;Knockout Mice;Lead;Lung;Lung Diseases;lung injury;Macrophage;Macrophage Activation;Mediating;Membrane;men;Metabolic;Metabolism;Mitochondria;Morbidity - disease rate;Mus;novel;novel strategies;Nuclear;Oxidative Phosphorylation;Oxidative Stress Induction;Ozone;ozone exposure;Pathogenesis;Pathway interactions;Phenotype;Play;PPAR gamma;Predisposition;prevent;Process;programs;Pulmonary Inflammation;receptor;Receptor Signaling;Regulation;Reporting;Repression;Research;Resolution;response;Role;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Testing;Therapeutic;tissue injury;tissue repair;Tissues;Toxic effect;Training;transcription factor;transcriptome sequencing;Transgenic Mice;Universities;Up-Regulation;Woman;wound healing

PROJECT_TITLE: Estrogen receptor signaling, inflammation and ozone toxicity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE This training grant renewal application requests continued support for our training program in Alzheimer's disease and related dementia (ADRD-TP). The foundation of this training program is an outstanding group of preceptors who have exceptional combination of expertise that permits and promotes the multidisciplinary training of versatile ADRD researchers. The Program is composed of four integrated themes of research training: (1) Biological Mechanisms (2) Drug Discovery and Development (3) Clinical (4) Biophysics, Bioinformatics and Computational Science. In addition, the program includes collaborative training with the pharmaceutical industry in drug development and clinical trials in ADRD. This program encourages trainees to integrate and cross information, in a way that stimulates complex problem solving, required for finding a cure for ADRD.

PI_NAMEs: COLOGNA, STEPHANIE M;LAZAROV, ORLY  (contact);TAI, LEON MAING

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's Disease;Biology;Dementia;Training Programs;Translational Research

PROJECT_TITLE: Training program in the biology and translational research on Alzheimer's diseaseand related dementias


NIH_SPENDING_CATS: Cancer;Immunotherapy;Obesity;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE The proposed study seeks to demonstrate that the omentin/TSG-6 axis plays a role in normalizing the pro- inflammatory omental microenvironment and preventing ovarian cancer development. This new understanding will enable us to delineate the immune modulator role of omentin in high-grade serous ovarian cancer (HGSC) pathogenesis, and to further develop omentin as low-toxicity chemopreventive and therapeutic agent for HGSC patients, ultimately improving their survival rates. Other prevention strategies that can upregulate omentin, such as weight loss and exercise programs, can also be developed to help prevent cancer metastasis and recurrence.

PI_NAMEs: AU YEUNG, CHI LAM  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: abdominal fat;Adipocytes;adipokines;Adipose tissue;angiogenesis;Anti-Inflammatory Agents;Attenuated;Binding;Body Weight decreased;cancer cell;cancer invasiveness;Cancer Patient;cancer recurrence;Cancer Survivor;cancer therapy;CD8-Positive T-Lymphocytes;Cell Density;cell growth;cell motility;Cell surface;cell type;Cells;chemokine;Chemopreventive Agent;Coupling;cytokine;Cytotoxic T-Lymphocytes;Development;effector T cell;efficacy evaluation;Endothelial Cells;Event;exercise program;Genes;Glucose;Glycosaminoglycans;Immune;immune cell infiltrate;Immune response;Immunologic Surveillance;Immunomodulators;Immunosuppression;improved;Infiltration;Inflammation;Inflammatory;innovation;Interstitial Collagenase;Intra-abdominal;Lactoferrin;Lymphocyte Activation;Lymphocytic Infiltrate;Malignant neoplasm of ovary;malignant phenotype;mass spectrometric imaging;Mediating;Mesothelial Cell;Metabolic;Motility;mouse model;mRNA Expression;Mus;Neoplasm Metastasis;novel;Nutritional;Omentum;ovarian neoplasm;Ovary;Paclitaxel;Pathogenesis;Patients;Peritoneal;pharmacokinetics and pharmacodynamics;Play;pressure;prevent;Prevention strategy;programs;Proliferating;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;receptor;Regulatory T-Lymphocyte;Reporting;Research;Role;secretory protein;Serous;Serum;Signal Transduction;Site;Stromal Cell-Derived Factor 1;Stromal Cells;Survival Rate;Survivors;T cell infiltration;T-Cell Activation;Testing;Therapeutic Agents;Time;Tissues;TNF gene;Toxic effect;Traction;trafficking;tumor;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;tumor-immune system interactions;Up-Regulation;uptake;Vascularization;Visceral

PROJECT_TITLE: Role of the pro-inflammatory omental microenvironment in ovarian cancer progression

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: GILGAMESH PHARMACEUTICALS INC

ORG_STATE: NY

PHR: PROJECT NARRATIVE Opioid use disorder (OUD) affects millions of people, while existing medications are not readily accessible and suffer from low patient compliance. Ibogaine, a natural substance, shows promise for OUD treatment, but poses considerable safety risks. Our team has developed a safer, synthetic alternative called "oxa-noribogaine" to revolutionize opioid addiction therapy and improve the lives of those struggling with substance use disorders.

PI_NAMEs: MAREK, GERARD JOSEPH (contact)

PROGRAM_OFFICER_NAME: HUBNER, CAROL B

PROJECT_TERMS: absorption;Abstinence;Acute;Address;Affect;Alkaloids;analog;Animals;appropriate dose;arm;Behavioral Assay;Biological Assay;Biological Markers;Canis familiaris;Cardiac;Cardiotoxicity;Chemistry;Clinical;clinical candidate;clinical development;Clinical Research;Clinical Trials;Cognition;Communities;Contracts;Coupling;craving;Cues;Data;depressive symptoms;design;Development;Devices;digital;disability;Dose;Dose Limiting;Drug Exposure;Drug Kinetics;early detection biomarkers;efficacy evaluation;efficacy study;Electroencephalography;Excretory function;FDA approved;first-in-human;Formulation;Generations;genotoxicity;Grant;healthy volunteer;Human;Iboga;Ibogaine;improved;In Vitro;in vivo;innovation;Interruption;intravenous administration;kappa opioid receptors;manufacture;manufacturing scale-up;Measures;medication for opioid use disorder;Metabolism;Monitor;Moods;Names;Natural Products;Natural Substance;neurotoxic;neurotoxicity;novel;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;opioid withdrawal;opportunity cost;overdose death;Participant;Patient Compliance;patient safety;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacotherapy;Phase;Phenotype;Placebo Control;Plasma;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical study;Preparation;primary endpoint;process improvement;Production;Prolactin;Property;prototype;Rattus;receptor;Regimen;Regulation;Reporting;Research;response;response biomarker;reward processing;Risk;Rodent;Route;Safety;safety assessment;safety study;secondary endpoint;Sedation procedure;Series;Speed;Substance Use Disorder;Testing;Therapeutic;Therapeutic Index;Toxic effect;Toxicology;United States;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Development of a Safer and More Effective Ibogaine Analog for the Treatment of Opioid Use Disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Aging;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE See Project Narrative attachment for parent grant U01DA052769. The activities proposed in this supplement application do not propose any changes to that attachment.

PI_NAMEs: REN, BING ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acceleration;Administrative Supplement;Age;aging related;Atlases;Brain;Brain Diseases;BRAIN initiative;Brain Pathology;Cell Nucleus;cell type;Cells;Data;data integration;Data Set;Disease;epigenome;epigenomics;Funding;Genes;Grant;Hippocampus;Human;human disease;improved;Joints;large scale data;Molecular;Multiomic Data;multiple omics;neural circuit;Neuroanatomy;normal aging;parent grant;Prefrontal Cortex;Regulatory Element;Research Personnel;single cell analysis;single cell genomics;transcriptome;United States National Institutes of Health;Visualization

PROJECT_TITLE: Single-cell analysis of aging-associated 4D nucleome in the human hippocampus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The retina, an outgrowth of the brain, is implicated in the development of Alzheimer's disease (AD). Although there is mounting evidence of a link between AD and age-related macular degeneration (AMD), the underlying molecular mechanisms that account for the similarities of these two neurodegenerative diseases are not yet well understood. This study aims to perform comparative single-cell data analysis to identify shared cell types and common cellular pathways between AD and AMD.

PI_NAMEs: DEANGELIS, MARGARET M;LI, MINGYAO ;STAMBOLIAN, DWIGHT EDWARD (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age related macular degeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Architecture;Area;Astrocytes;Autopsy;Axon;beta-site APP cleaving enzyme 1;Biochemical;Biological;Biology;Blood;Brain;brain control;BRAIN initiative;Cell Communication;cell type;Cells;Cerebrum;Choroid;comparative;Complex;Data;Data Analyses;data harmonization;Data Set;denoising;Deposition;Development;Diagnosis;differential expression;Disease;Drusen;extracellular;Eye;Gene Expression Profile;Genes;Goals;Human;hyperphosphorylated tau;imaging approach;in vivo Model;insight;intercellular communication;Knowledge;Link;machine learning algorithm;Microglia;minimally invasive;Modeling;Molecular;Morphology;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;neuropathology;new therapeutic target;novel;Optic Nerve;parent grant;Parents;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Precision therapeutics;Property;Protein Biosynthesis;Proteins;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal nerve fiber layer;retinal neuron;secretase;Senile Plaques;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;statistical and machine learning;tau Proteins;therapeutic target;Thinness;Tissue-Specific Gene Expression;transcriptome sequencing;Transportation;vascular abnormality;Visual;Visualization;web site;β-amyloid burden

PROJECT_TITLE: Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narratives The brain consists of structures and neural circuits that are nonlinearly organized in nature. Electrophysiological mapping of complete structures or circuits is critical to understand their functional organization, synaptic connectivity, and signal processing. This project explores a new modality that allows the nonlinear implantation of flexible neural probes to conformally cover designated structures or circuits at minimal surgical lesions and thus enables mapping nonlinear brain trajectories at unprecedented spatial resolution.

PI_NAMEs: LIN, DINGCHANG  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Action Potentials;Anatomy;Atlases;Biological Models;biomaterial compatibility;Brain;Brain Mapping;Brain region;brain tissue;carbon fiber;Catheters;Central Nervous System;Characteristics;Chronic;Code;Complex;Computational algorithm;cranium;density;design;Devices;Dimensions;Electrodes;Electrophysiology (science);Emotions;Engineering;extracellular;flexibility;fluorescence imaging;Gel;hippocampal pyramidal neuron;Hippocampus;Human;Implant;implantation;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Individual;Injections;innovation;integrated circuit;interest;Intervention;Lesion;Maps;mechanical properties;Memory;memory process;Methodology;Methods;Microelectrodes;Modality;Molecular;Molecular Conformation;Mus;Nature;neural;neural circuit;Neurons;Neurosciences Research;Operative Surgical Procedures;Outcome;Penetration;Phase;place fields;Polymers;Positioning Attribute;Property;Research;Resolution;Rodent;Route;Saline;Sepharose;Shapes;signal processing;Signal Transduction;Silicon;Spottings;Stains;Structure;success;Synapses;System;Technology;Testing;Time;Tissues;Training;translational neuroscience;Tungsten;Unnecessary Surgery

PROJECT_TITLE: Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and Circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (08)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Houston

ORG_NAME: CELLCHORUS INC.

PHR: 8. Project Narrative To develop and deliver novel therapies such as antibody therapeutics, cell therapies and vaccines, scientists need to be able to study how large numbers of individual cells perform over time. CellChorus has developed an artificial intelligence-powered platform that evaluates the performance of thousands of individual cells over time. This project will support scaling the platform from the company’s lab to an instrument that can be placed in any laboratory or therapeutic manufacturing facility.

PI_NAMEs: COOPER, LAURENCE J.N. (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Academia;Adoption;Algorithms;Antibodies;Apoptosis;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Basic Science;Behavior;Biological Assay;Biological Products;Biology;biopharmaceutical industry;cell behavior;Cell Communication;cell motility;Cell Physiology;Cell Therapy;cell type;Cells;Cellular biology;Cellular Morphology;Characteristics;Classification;clinical biomarkers;clinical development;cluster computing;commercial application;commercialization;Communicable Diseases;Computer software;cytokine;Cytometry;cytotoxicity;Data Analyses;design;Detection;Development;Discipline;Disease;Effector Cell;Elements;experimental study;flexibility;Flow Cytometry;Frequencies;Genomics;Heterogeneity;Image;image processing;Immune;improved;Individual;individual variation;Industry;Institution;instrument;instrumentation;interest;Label;Laboratories;Letters;Link;live cell imaging;manufacture;Manufacturer;manufacturing facility;Measures;Medical;microscopic imaging;Microscopy;migration;Modality;Modeling;Molecular Profiling;Movement;nano;Network-based;neural network;Noise;novel therapeutics;Nuclear Translocation;Oncology;Organelles;Output;Peer Review;Performance;Pharmaceutical Preparations;Phase;preclinical development;programs;Property;Protein Analysis;Protein Secretion;Protein translocation;Proteins;prototype;Publications;Reagent;Research;Research Contracts;Research Personnel;Resolution;Science;Scientist;Service delivery model;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Software Tools;spatiotemporal;success;Supervision;Synapses;T-Lymphocyte;Techniques;Technology;technology development;Testing;Therapeutic;Therapeutic antibodies;Time;Training;transcriptomics;trend;Tube;user-friendly;Vaccines

PROJECT_TITLE: Dynamic single-cell analysis instrument to evaluate immune cell function


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: BIOPHYSICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The brain processes information through the collective activity of large networks of neurons that integrate incoming stimuli and respond by sending precisely timed electrical impulses towards their neighbors. Here we propose to develop a novel computational microscopy method designed to capture the signals emitted from fluorescent voltage-sensing reporter proteins across large volumes of mammalian brain tissue and thus measure electrical neuronal activity from thousands of individual neurons. This unprecedented recording capacity will enable precision studies of how neuronal network activity works on a fundamental level and will allow insights into how it is altered in pathological disorders of the human brain. 1

PI_NAMEs: OENOL-NOEBAUER, TOBIAS  (contact)

PROJECT_TITLE: Computational volumetric one-photon voltage imaging in rodents


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Accurate chromosome segregation critically depends on the effective attachment between kinetochores of the chromosomes and microtubules of the mitotic spindle. Defective kinetochore-microtubule attachments lead to chromosome mis-segregation and aneuploidy. Our work will examine new mechanisms that control kinetochore- microtubule attachments to prevent chromosome mis-segregation. Our long-term goal is to understand how defects in these mechanisms lead to the biogenesis and progression of cancer generated by aneupoidy.

PI_NAMEs: VARMA, DILEEP  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;aurora B kinase;Binding;Binding Proteins;Binding Sites;Biogenesis;Biological Models;cell assembly;Cellular Structures;Centromere;chromosome conformation capture;chromosome missegregation;Chromosome Segregation;Chromosomes;Complex;daughter cell;Defect;Distal;Dynein ATPase;Goals;Human;Kinetochores;Lateral;Lead;Mediating;Metaphase;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;Motor;Multiprotein Complexes;N-terminal;novel;Pathway interactions;Phosphorylation;prevent;Process;Prometaphase;Proteins;recruit;Replication Licensing;Role;segregation;Sister;Site;Slide;synergism;tumor progression;Work

PROJECT_TITLE: Molecular mechanisms controlling kinetochore-microtubule attachments during mitosis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Pregnancy;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We have assembled a multi-institutional collaborative center with the aim of creating a cellular taxonomy of molecularly defined cell types in the developing human, Rhesus macaque, and marmoset brain. Our project employs technologies for automated single nucleus and spatially-resolved RNA-sequencing and single cell transposase accessible chromatin sequencing to create spatial gene expression and epigenomic developmental expression maps for human and NHP brain. We will sample 30 brain regions at four key epochs of development and register our cellular data onto MRI-based Common Coordinate Frameworks to create a unique resource that will serve as a blueprint for studies of human brain function and selective vulnerability of cell types to disease and will provide foundational data for the development of primate and in vitro models.

PI_NAMEs: BHADURI, APARNA ;DAADI, MARCEL ;HUANG, HAO ;KRIEGSTEIN, ARNOLD  (contact);LEVINE, JON E;NOWAKOWSKI, TOMASZ ;POLLEN, ALEXANDER A;SESTAN, NENAD

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Adolescence;Adult;Affect;Anatomy;ATAC-seq;Atlases;autism spectrum disorder;Brain;brain cell;Brain Diseases;BRAIN initiative;Brain region;Callithrix;cell cortex;Cell Lineage;Cell Nucleus;cell type;Cells;Censuses;Childhood;Chromatin;Code;Complex;Cortical Cell Layer;Data;Data Analyses;Data Collection;data harmonization;Data Set;Development;Disease;Epigenetic Process;epigenome;epigenomics;Etiology;First Pregnancy Trimester;Freezing;Gene Expression;gene network;gene regulatory network;Genes;Genetic Transcription;Genetic Variation;Genomics;Glioblastoma;Goals;Heterogeneity;Human;human data;Human Development;human disease;human model;improved;in vitro Model;Individual;innovation;Institution;Intellectual functioning disability;interest;Joints;Knowledge;life span;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Malignant neoplasm of brain;Maps;Methods;Modality;Molecular;Monitor;Mouse Strains;multidisciplinary;Mus;Nature;Neonatal;Neurodevelopmental Disorder;neuropsychiatric disorder;nonhuman primate;novel;Pattern;Population;postnatal;Pregnancy;prenatal;primate development;Primates;programs;Property;Publishing;Regulation;Regulatory Element;repository;Resolution;Resources;RNA;sample collection;Sampling;Schizophrenia;Second Pregnancy Trimester;Series;single cell analysis;Spatial Distribution;Taxonomy;Technology;Third Pregnancy Trimester;Time;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transposase;tumor;tumor initiation;tumor progression;Validation

PROJECT_TITLE: A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell Atlases


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative This project aims to harmonize single-cell transcriptomics datasets from various neurodegenerative diseases with BRAIN Initiative-generated reference data to create a comprehensive atlas of cell types and states in the human brain across the neurodegenerative disease spectrum, offering valuable insights into shared and distinct molecular mechanisms underlying these disorders.

PI_NAMEs: SWARUP, VIVEK  (contact);ZHANG, JING

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Atlases;Autopsy;Brain;Brain Diseases;BRAIN initiative;brain tissue;cell type;Cells;cohort;Communities;Complex;computerized tools;Coupled;Data;data harmonization;data integration;Data Set;Development;Disease;Disease Progression;diverse data;Funding;Gene Expression;Gene Expression Alteration;Genetic Markers;Genetic Transcription;Goals;Heterogeneity;Human;human data;insight;Joints;Maps;Methods;Molecular;Multiple Sclerosis;Nerve Degeneration;Neurodegenerative Disorders;Neurosciences;novel;novel marker;Parkinson Disease;Pathogenesis;Pathologic;Persons;Population;Process;Publishing;Quality Control;Research Personnel;Resources;Sampling;single nucleus RNA-sequencing;Standardization;targeted treatment;therapeutic target;transcriptomics

PROJECT_TITLE: Harmonization and Joint Analysis of Human Brain Single-Cell Datasets


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: GREER

ORG_NAME: NUBAD, LLC

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed project presents a mentoring and training strategy in the development of novel antimicrobials with novel rRNA discriminating recognition oligomers. Antimicrobial resistance occurs when microorganisms (often infectious bacteria, viruses, and certain parasites) are no longer sensitive to drugs that were previously used to treat them; this is of global concern because it hampers our ability to control infectious disease and increases the costs of health care. In order to combat this world-wide problem, innovative strategies for antibiotic drug design must be implemented. The proposed research describes such a mentoring and training plan using novel antimicrobial compounds that evade common resistance pathways.

PI_NAMEs: ARYA, DEV PRIYA (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;aspirate;Bacteria;Binding;Biology;biophysical techniques;Chemicals;Chemistry;combat;Communicable Diseases;Development;Drug Design;efficacy evaluation;Health Care Costs;innovation;Learning;Mentors;microorganism;novel;Organic Chemistry;Parasites;Pathway interactions;Peptide Nucleic Acids;Pharmaceutical Preparations;Research;Research Personnel;Resistance;Ribosomal RNA;Science;success;Therapeutic;Training;Virus;Work

PROJECT_TITLE: Development of peptide nucleic acid antibiotics-supplement 1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The overarching goal of the proposed project is to understand the molecular mechanism of Alzheimer's disease and related dementias (ADRD) by leveraging the publicly available single-cell data from human brain tissues. We will apply the novel machine learning methods for gene regulatory network construction proposed in our parent R01 to single-cell data from healthy individuals and patients with ADRD. Results from these analyses will augment the power of the statistical analysis in our funded R01 study; and collectively facilitate the development of new strategies to prevent, delay, and treat ADRD.

PI_NAMEs: BOWMAN, AARON B (contact);YUAN, CHONGLI ;ZHANG, MIN

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Accounting;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;BRAIN initiative;brain tissue;Cause of Death;Cells;Chemistry;Chromatin;Chromatin Structure;cohort;Collection;Color;Communities;Complex;Data;data harmonization;Data Set;Databases;Dependence;Development;disability;Disease;effective therapy;Elderly;Ensure;Environment;Environmental Risk Factor;Epigenetic Process;Evaluation;Exposure to;Foundations;functional genomics;Funding;gene environment interaction;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genome-wide;Genomic approach;Goals;Grant;high dimensionality;Human;human data;human induced pluripotent stem cells;improved;in vitro Model;in vivo;Indiana;Individual;insight;instrument;Intervention;Least-Squares Analysis;Life Style;Machine Learning;machine learning method;Measurement;Methods;Modeling;Molecular;molecular dynamics;Multiomic Data;Nerve Degeneration;Neurologic;neurotoxic;neurotoxicity;novel;open source;Parents;Pathway Analysis;Pathway interactions;Patients;Penetrance;Persons;Play;Population;Predisposition;prevent;Process;programs;Public Health;reference genome;Regulation;Research;resilience;Resolution;RNA;Role;Rural;Sampling;Scientist;Severities;Siblings;single cell analysis;single cell genomics;single cell sequencing;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;Small Nuclear RNA;Statistical Data Interpretation;Statistical Methods;success;Synapses;Technology;Testing;therapeutic target;tool;Toxic Environmental Substances;Toxicology;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transposase;Validation;web site;Work;XCL1 gene

PROJECT_TITLE: Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohort


NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The primary objective of this proposal is to evaluate the combined effects of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in alleviating pain and opioid craving among individuals living with both opioid use disorder (OUD) and chronic pain. Results will offer insights into the potential of THC/CBD combinations as a novel treatment for this vulnerable population. Additionally, our approach to developing new therapies for this population aligns with national health priorities, timely informing patients, healthcare professionals, and policy stakeholders about the risks and benefits of cannabinoid-based medicines during the opioid crisis.

PI_NAMEs: DE AQUINO, JOAO PAULO (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: abuse liability;addiction;Address;Adverse effects;Affect;Analgesics;Behavior;Benchmarking;Benefits and Risks;Blood;Cannabidiol;Cannabinoids;Cannabis;Central Nervous System;central sensitization;Chronic;Chronic low back pain;chronic pain;chronic pain management;Clinical;CNR1 gene;Cognitive;craving;Cues;design;Dose;Double-Blind Method;drug development;Drug Interactions;drug reinforcement;DSM-V;effective therapy;endogenous cannabinoid system;Enrollment;experience;Health Priorities;Health Professional;Heroin;Human;Hyperalgesia;indexing;Individual;insight;Knowledge;Laboratory Study;Lead;Link;Low Back Pain;Maintenance;Measures;Medicine;men;Methadone;model development;Modeling;Morbidity - disease rate;mortality;multimodality;neglect;neuroadaptation;neuronal excitability;neuroprotection;neurotransmitter release;Nociception;non-opioid analgesic;novel;novel therapeutic intervention;novel therapeutics;Opiate Addiction;Opioid;Opioid agonist;opioid agonist therapy;opioid epidemic;opioid misuse;opioid therapy;opioid use disorder;Oral;Outcome;Pain;Pain management;Pain Measurement;pain relief;pain sensitivity;pain signal;Participant;Patients;performance tests;Persons;Pharmaceutical Preparations;Placebo Control;Placebos;Plasma;Policies;Population;Process;Property;Psychomotor Impairments;Psychomotor Performance;Qualifying;Randomized;Relapse;Research;Research Personnel;response;Sensory;sex;Signal Transduction;Testing;Tetrahydrocannabinol;Therapeutic Effect;Treatment outcome;United States National Institutes of Health;Visual;Vulnerable Populations;Woman

PROJECT_TITLE: Combination of THC and CBD as a Novel Treatment for Co-Occurring Opioid Addiction and Chronic Pain

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: This supplement to our R01AG076949 will harmonize and jointly analyze our single nuclei and spatial multiome datasets obtained from neurotypical subjects from adolescence into the 90s and Alzheimer’s Disease brains, with BRAIN Initiative-generated datasets from human brain tissue. We will integrate multiome data from different brain regions involved in AD neuropsychiatric symptoms, including hippocampus, amygdala and prefrontal cortex, to implement analyses on gene regulatory networks that are common to neurons and glial cells across brain regions, and identify those that synergistically regulate functional brain circuits involved in cognitive, emotional, and behavioral changes in AD. This project will provide information on the regulome, the interaction between regulatory components that control the state of expression of genes and their isoforms, their subcellular location, tissue state, development, and pathology, and deliver a developmental and adult cell atlas of cell type diversity, that will be shared via an NIH supported database.

PI_NAMEs: BOLDRINI, MAURA  (contact);MANN, JOSEPH JOHN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Adolescence;Adult;adult neurogenesis;Affect;Age;Aggressive behavior;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amygdaloid structure;Anatomy;angiogenesis;Anxiety;ATAC-seq;Atlases;attentional control;Award;Bar Codes;Behavioral;Brain;brain cell;BRAIN initiative;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Censuses;Childhood;Chromatin;Chromosome Mapping;Cognitive;comparative;Custom;Data;Data Analyses;data archive;Data Set;Databases;Decision Making;Development;differential expression;Disease;Disinhibition;DNA;DNA Methylation;Education;Emotional;emotional distress;Environmental Risk Factor;Epigenetic Process;epigenome;Escape Reaction;fighting;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genomics;Heterogeneity;Hippocampus;HIV;Human;ideation;improved;Impulsivity;indexing;Joints;Link;Location;Major Depressive Disorder;Maps;Mass Spectrum Analysis;Measures;Memory;Messenger RNA;Metadata;MicroRNAs;Modeling;Molecular;Molecular Profiling;mRNA Transcript Degradation;multimodality;Multiomic Data;neurogenesis;Neuroglia;Neurons;neuropsychiatric symptom;Neurosciences;new therapeutic target;normal aging;novel therapeutic intervention;Opioid;Pathogenesis;Pathology;Pathway Analysis;Prefrontal Cortex;protein expression;Protein Isoforms;Proteins;Proteome;Proteomics;psychotic symptoms;public database;Regulation;Regulatory Element;Resolution;Resources;response;Ribosomes;RNA;RNA Splicing;RNA-Protein Interaction;senescence;Severities;sex;Signal Transduction;single nucleus RNA-sequencing;Slide;Stress;Technology;Tissues;Topical application;transcription factor;Transcription Initiation Site;transcriptome sequencing;transcriptomics;Translational Repression;United States National Institutes of Health;Untranslated RNA;XCL1 gene

PROJECT_TITLE: Harmonization and Joint Analysis of Human Brain Single-Cell Datasets from Neurotypical Aging Controls and Alzheimer's Disease Patients


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE To find vaccines and cures for HIV, scientists who work with non-human primates need to have opportunities to collaborate and learn from other scientists who study HIV in humans. We propose to hold four annual scientific meetings to promote collaboration among HIV researchers conducting both types of research. At the conferences, scientists early in their careers will hear about novel research, learn career development skills, and network with scientists and mentors to accelerate scientific discoveries to cure HIV and to develop HIV vaccines.

PI_NAMEs: KUBLIN, JAMES G. (contact);ROXBY, ALISON CHRISTINA

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Award;career;career development;Cicatrix;Clinical;Clinical Trials;co-infection;Collaborations;Communities;comorbidity;cost;COVID-19 pandemic;COVID-19 vaccine;data sharing;Development;Disabled Persons;Education;Engineering;Ensure;Environment;Epidemic;Evaluation;Event;experience;Exposure to;Faculty;Fees;Funding;Future;Goals;Group Meetings;Hearing;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;Home;Human;Immunology;Information Dissemination;Injectable;innovation;interest;Intervention;investigator training;Investments;Knowledge;Laboratories;Learning;Manuscripts;Mediation;meetings;Mentors;Modeling;Monoclonal Antibodies;Needs Assessment;next generation;nonhuman primate;novel;novel strategies;novel vaccines;operation;pandemic disease;peer;Peer Review;Persons;Phase;Positioning Attribute;pre-clinical;Prevention Research;Primates;Process;Reagent;Request for Applications;Research;Research Design;Research Personnel;Research Support;Scholarship;Science;Scientist;Secure;Side;skill acquisition;skills;Speed;symposium;Talents;Techniques;Therapeutic;Therapeutic Research;Time;timeline;Training;Translational Research;translational research program;translational scientist;Travel;Tuberculosis;Tuberculosis Vaccines;Underrepresented Minority;United States National Institutes of Health;vaccine distribution;vaccine platform;Vaccine Research;vaccine trial;Vaccines;Washington;Woman;Work;Workforce Development;Writing

PROJECT_TITLE: Annual HVTN Translational HIV Early Stage Investigator (ESI) Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This study will evaluate a novel intervention that integrates family- and community-level factors to mitigate the harms of Adverse Childhood Experiences (ACEs) exposure and prevent future ACEs while preventing substance use and overdose. We will test (1) whether this intervention increases referrals and linkages to community resources, increases positive family functioning, and reduces youth and parent substance use and ACEs; and (2) if the integrated intervention produces systems-level change vis-à-vis alignment of services and resources. Our findings will provide insight about the best ways to help disproportionately affected communities prevent substance use, overdose, and ACEs.

PI_NAMEs: ELGIN, DALLAS ;GRAHAM, PHILLIP W (contact)

PROJECT_TITLE: RFA-CE-22-009 Rigorous Evaluation of Community-Level Substance Use and Overdose Prevention Frameworks that Incorporate ACEs-Related Prevention Strategies


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: EAST LANSING

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This project is relevant to public health, and specifically occupational health and safety, because it addresses all three core functions in public health: collection and analysis of data, building partnerships to promote the goal of tracking and using the data to prevent occupational injuries and illnesses. A variety of strategies will be used to ensure that surveillance data are of high quality, that stakeholders and the public are aware and have access to the data, and that the data drive prevention activities.

PI_NAMEs: HARDUAR MORANO, LAUREL  (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Expanded Program in Occupational Injury and Illness Surveillance


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: This project will identify biologic mechanisms underpinning the temporal continuum in the lung following occupational bio-aerosol bacterial and viral component exposure-induced lung inflammation that will potentially lead to novel therapeutic lung-directed strategies aimed at hastening resolution of lung inflammatory disease processes following exposure to occupational inhalant biohazards.

PI_NAMEs: POOLE, JILL A (contact)

PROJECT_TITLE: Resolving Occupational Exposure-Induced Lung Disease

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: This year, VHA is implementing a new suicidal ideation (SI screening) and evaluation process, VA Risk-ID. However, prior research has shown that Veterans often do not disclose SI at healthcare visits just prior to suicide, and that Veterans frequently feel uncomfortable disclosing SI during screening. The purpose of this project is to is to develop a greater understanding of the impacts of VA Risk-ID screening processes, primarily from the Veterans’ perspective. Up to 2,000 Veterans nationally will complete surveys that assess their satisfaction with screening, patient-care team interactions, and perceived barriers to care and SI disclosure. Up to approximately 40 Veterans and 40 clinical staff members from primary care and mental health settings will participate in qualitative interviews. We will also examine if perceptions of screening and care team actions at the time of screening are related to subsequent engagement of Veterans in mental health treatment. This project will lay groundwork for the development of new approaches and interventions to improve SI screening.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Address;Affect;Afghanistan;anti-depressive agents;barrier to care;Caring;Cessation of life;Characteristics;Clinical;cohort;Collaborations;Data;data warehouse;Detection;Development;Disclosure;Elements;Evaluation;experience;Feeling suicidal;Goals;Health;Health Care Visit;Health Personnel;Healthcare;improved;Individual;innovation;Intervention;Interview;Iraq;Knowledge;Letters;Measures;Medical;Medical Care Team;medical specialties;member;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Modeling;Movement;Natural History;novel strategies;Outcome;Pathway interactions;Patient Care Team;patient engagement;patient population;Patient Preferences;Patient-Centered Care;patient-clinician communication;Patients;Perception;Pharmaceutical Preparations;Population;population based;Post-Traumatic Stress Disorders;Primary Care;primary care team;Process;process evaluation;Provider;Recommendation;recruit;reducing suicide;Reporting;Research;research clinical testing;Respondent;response;Risk;Sampling;satisfaction;screening;screening program;Screening Result;Self Direction;Site;Structure;suicidal risk;Suicide;Suicide prevention;Surveys;systematic review;Testing;Therapeutic;treatment optimization;treatment planning;tv watching;Veterans;Veterans Health Administration;Violence;Visit;War

PROJECT_TITLE: Understanding Impact of VHA's New Suicidal Ideation Screening Initiative: Veteran's Perspective

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The loss of stable housing has a devastating effect on Veterans' health and well-being. Through the Supportive Services for Veteran Families (SSVF) program, Veterans and their families who are experiencing homelessness or who are at risk of becoming homeless can receive of financial support and other services from private non-profit organizations and consumer cooperative grantees with the goal of stabilizing their housing. The impact on Veteran housing, healthcare cost, and health outcomes as well as Veteran satisfaction with the SSVF program is not known. Through this project, we will generate important information about the SSVF program. We will use nationwide data to describe the geographic variation in SSVF services and expenditures throughout the country. We will measure the impact of SSVF on Veteran housing status, healthcare cost and utilization, and mortality. And finally, we will interview SSVF participants to better understand barriers and facilitators to SSVF use and Veteran satisfaction with the program.

PI_NAMEs: NELSON, RICHARD E. (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Attitude;Characteristics;Cohort Analysis;Communities;Community Healthcare;community partners;cost;cost effective;cost outcomes;Country;Data;Death Rate;economic evaluation;Economics;Effectiveness;Employee;Enrollment;Expenditure;experience;Family;Financial Support;geographic difference;Geographic Locations;Goals;Health;Health Care Costs;health economics;Healthcare Systems;Heterogeneity;Homeless persons;Homelessness;Housing;housing instability;implementation strategy;improved;improved outcome;Individual;innovation;Inpatients;insight;Intervention;Interview;Investments;Literature;Management Information Systems;Measures;Methodology;Methods;Modeling;models and simulation;mortality;mortality risk;Nonprofit Organizations;operation;Outcome;Outcome Assessment;Outpatients;Paper;Participant;Personal Satisfaction;Population;Privatization;Program Evaluation;Program Sustainability;programs;Publishing;Quality-Adjusted Life Years;Reporting;Research;Resources;Retrospective cohort;Risk;satisfaction;service providers;Service provision;Services;Site;Societies;Source;Structure;structured data;Suicide;Suicide prevention;treatment as usual;unstructured data;Variant;Veterans;Work

PROJECT_TITLE: Measuring the impact of the Supportive Services for Veteran Families (SSVF) on Veteran outcomes


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative GTPases are proteins that play a key role in the molecular signaling pathways involved in learning and memory, and are misregulated in Alzheimer’s Disease. Here, we propose to investigate the regulation of GTPases in living neurons, in real time. Results from our experiments will provide a greater understanding of the fundamental processes behind learning and memory in the brain, and could lead to the identification of novel therapeutic targets for Alzheimer’s Disease.

PI_NAMEs: PETSHOW, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acute;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Attention;Bicuculline;Binding;Biosensor;Brain;cell injury;cognitive ability;Communication;Coupled;Data;Data Set;Dendritic Spines;density;Disease;ephexin;Excitatory Synapse;experimental study;Exposure to;fighting;fluorescence lifetime imaging;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Glutamates;Goals;Guanosine Triphosphate Phosphohydrolases;hippocampal pyramidal neuron;Hippocampus;Homologous Gene;Image;in vitro Model;Individual;Induced Neurons;insight;knock-down;Knockout Mice;Knowledge;Learning;Ligation;Liquid Chromatography;live cell imaging;Mass Spectrum Analysis;Measures;Mediating;Memory;memory acquisition;Memory impairment;Memory Loss;Mentors;Mentorship;Microscopic;mimetics;Molecular;mouse model;Mus;mutant;Neurodegenerative Disorders;Neurons;neurotransmission;new therapeutic target;Optics;Pathway interactions;Pattern;Persons;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Physiology;Play;preference;Process;promoter;protein function;protein structure;Proteins;Regulation;Research Project Grants;response;rho GTP-Binding Proteins;Role;Sampling;sensor;Signal Pathway;Signal Transduction;Signal Transduction Induction;Site;skills;Slice;spatiotemporal;Structure;Substrate Specificity;Synapses;tandem mass spectrometry;Technical Expertise;Testing;therapeutic target;Time;Tissue Sample;Tissues;training project;Transfection;two-photon;Vertebral column;Writing

PROJECT_TITLE: Uncovering the mechanisms of Ephexin5 function in dendritic spine plasticity and Alzheimer's disease


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Neurosciences;Pain Research;Prevention;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This project will investigate cardiac interoception as a possible biomarker of chronic pain that is maintained by telencephalic as opposed to peripheral mechanisms, where poorer interoceptive behavioral and neural performance would predict non-response to peripherally targeted treatments. Using EEG measures of the Heartbeat-Evoked Potential during interoceptive tasks, this project will establish the clinical relevance of interoception to chronic pain by comparing healthy adults, chronic low back pain patients pre-back surgery, and those who have not received pain relief from back surgery and have been diagnosed with Failed Back Surgery Syndrome and will receive a spinal cord stimulator for pain management. A cross-sectional design across the continuum of care for complex low back pain will enable identification of cardiac interoceptive processes that can predict non-response to peripheral pain treatment.

PI_NAMEs: ZIMMERMAN, CHLOE S (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acute Pain;Adult;Agreement;Attention;attentional modulation;Back;Back Pain;Behavior Therapy;Behavioral;Biological Markers;Brain region;Cardiac;Caring;Central Nervous System;central pain;Chronic;Chronic low back pain;chronic pain;chronic pain patient;Clinical;clinically relevant;comparison control;Complex;Continuity of Patient Care;daily pain;Data;data acquisition;design;Diagnosis;Disease;Early identification;Electrocardiogram;Electroencephalography;Electrophysiology (science);Evoked Potentials;experience;experimental study;Funding;Future;healing;Healthcare Systems;Heart;Impairment;Implant;improved;indexing;Integrative Medicine;Interoception;Intervention;Knowledge;Lead;Link;Low Back Pain;Measurement;Measures;Medical;Mentors;Mind-Body Intervention;mindfulness;Modality;Moods;Motivation;multimodality;National Research Service Awards;neural;neuromechanism;Neurostimulation procedures of spinal cord tissue;Noise;Nonpharmacologic Therapy;observational cohort study;Operative Surgical Procedures;opioid epidemic;Pain;pain chronification;Pain management;pain patient;pain perception;pain reduction;pain relief;Painless;paired stimuli;Parents;Participant;patient population;Patient Recruitments;Patient Self-Report;Patients;Performance;Peripheral;peripheral pain;Persistent pain;Phase;Physicians;Positioning Attribute;Preparation;Prevalence;primary outcome;Probability;Process;Prosencephalon;prospective;psychobiologic;Qi Gong;Questionnaires;recruit;remediation;Research;response;Running;secondary analysis;secondary outcome;Selection for Treatments;Sensory;Severities;Signal Transduction;smartphone application;Spinal Cord;Spine surgery;Stimulus;Syndrome;Tai Ji;Testing;Time;Training;treatment comparison;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: Identifying EEG Markers of Altered Interoceptive Processing in Chronic Pain


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Microbiome;Pediatric;Prevention;Rare Diseases

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF MELBOURNE

PHR: PROJECT NARRATIVE The Colon Cancer Family Registry Cohort is well established and has been the resource of many studies of colorectal cancer. If the infrastructure grant is funded, the public health relevance gained by an additional 5- years of follow-up and innovative characterization to further enhance the cohort, will lead to a new wave of research for risk factors for the colorectal cancer, new ways of preventing the disease, and new ways to treat the disease.

PI_NAMEs: BUCHANAN, DANIEL DAVID;GALLINGER, STEVEN ;JENKINS, MARK A (contact);LE MARCHAND, LOIC ;PHIPPS, AMANDA IRENE;SAMADDER, NILOY JEWEL;SCHMIT, STEPHANIE L.

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: 18 year old;Address;Age;Agreement;Alcohols;anti-cancer research;Australia;biobank;Blood;BRAF gene;Calibration;Canada;cancer diagnosis;Cancer Survivor;cancer type;Cancer-Predisposing Gene;Certification;Cessation of life;Characteristics;Child;Clinical;Clinical Data;cloud storage;cohort;Cohort Studies;colon cancer family registry;colon carcinogenesis;Colorectal;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Communities;Computer Security;cost;COVID-19 impact;Data;data harmonization;data sharing;data standards;database of Genotypes and Phenotypes;design;Development;Diagnosis;digital;Disease;DNA;Electronic Health Record;Ensure;Environmental Risk Factor;Epidemiology;Equipment;Escherichia coli;Etiology;Event;familial colorectal cancer;Family;Family history of;Family member;fecal microbiota;follow-up;Funding;Gases;Generations;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genetic testing;genome wide association study;genomic signature;Genotype;Germ Lines;Germ-Line Mutation;grandchild;Grant;gut bacteria;Health;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Human;Individual;Industry Standard;Informatics;Infrastructure;innovation;International;Intestines;KRAS2 gene;Life;Liquid substance;Maintenance;Malignant Neoplasms;marijuana use;Medical Records;member;Methylation;microbiome;Minority;Mismatch Repair;MLH1 gene;Molecular;Mutation;neoplasm registry;next generation;Nitrogen;Operative Surgical Procedures;oral microbial community;oral microbiome;Participant;Pathology;Pathology Report;patient portal;Patients;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;population based;preservation;prevent;Prevention;Preventive;proband;Procedures;Prognosis;Public Health;public health relevance;Publications;Questionnaires;Recording of previous events;Records;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;Role;Sampling;Scanning;Science;screening;Screening for cancer;Screening Result;Secure;sharing platform;Site;Slide;Smoking;Somatic Mutation;Specimen;Standardization;Surveys;survivorship;Syndrome;Test Result;Testing;tumor;Update;virtual;waist circumference;web site;Work

PROJECT_TITLE: Colon Cancer Family Registry Cohort


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.

PI_NAMEs: STEFFENS, DAVID C. (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Adult;Alzheimer's Disease;anti-depressive agents;Anxiety;Behavioral;Brain;Brain imaging;Brain region;Buffers;Clinical;Clinical Trials;Cognition;Cognitive;cognitive testing;Complex;coping;COVID-19 pandemic;Data;Dementia;Depressed mood;depression model;Desire for food;Development;Diagnosis;Disease remission;Economics;Elderly;Enrollment;Epidemiology;executive function;Exercise;experience;Feeling;Frustration;functional disability;Functional Magnetic Resonance Imaging;functional MRI scan;Future;geriatric depression;Health;high risk;Hippocampus;Homeostasis;Image;imaging study;Impaired cognition;Individual;interpersonal conflict;Lead;Life;Major Depressive Disorder;Measures;Medial;Mediating;Medical;Mental Depression;Modeling;Moods;neural;neural network;Neurobiology;Neurotic Disorders;novel;older adult;Outcome;Pattern;Personality;Personality Traits;Pharmaceutical Preparations;Phenotype;Predisposition;Prevention strategy;previous pandemic;Psychotherapy;Recording of previous events;recruit;Recurrence;recurrent depression;Relapse;resilience;response;Risk;Scanning;Security;serial imaging;Severities;Sleep disturbances;social;Social support;Statistical Models;Stress;stressor;Structure;suicidal risk;Vascular Dementia;Withdrawal

PROJECT_TITLE: Phenotype Predictors of Cognitive Outcomes in Geriatric Depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PI_NAMEs: CHESNEY, JASON A.;YAN, JUN  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TITLE: TBD


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Virus-host interactions and microbial ecology Using E. coli as our model organism, we propose to explore how the DNA-loop extruding condensin motor complex, conserved from bacteria to humans, organizes the genome such that there are widespread contacts between all genomic loci, a finding that has implications for DNA rearrangements, evolution, and cancers. We also propose to understand why, when the bacteria associate in a group and swarm over a surface, they are protected against lethal levels of antibiotics by a subpopulation of dead bacteria. This research has implications for the enhanced drug efflux seen in chemotherapy-resistant cancers.

PI_NAMEs: HARSHEY, RASIKA M (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 3-Dimensional;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Bacteria;Bacteriophage mu;Cell Communication;cell growth;cell killing;Cessation of life;Chemoresistance;Chromatin Loop;Chromosomes;Complex;condensin;Drug Efflux;Ecology;efflux pump;Escherichia coli;Evolution;Exposure to;Gene Expression;Gene Family;Gene Rearrangement;genetic resistance;Genome;genomic locus;Genomics;Gram-Negative Bacteria;Grant;Growth;HU Protein;Human;in vivo;Incubators;Malignant Neoplasms;Measures;Membrane;microbial;Microbiology;model organism;Motor;non-genetic;Operon;Paste substance;Pathway interactions;periplasm;Production;Property;Pump;refractory cancer;Research;Resistance;Resolution;response;Ribosomal RNA;Salmonella;Specificity;Surface;tool;virus host interaction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Genetics;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Migraine is a painful, chronic neurological disorder that represents the second most disabling illness worldwide. This proposal investigates how two mechanisms that contribute to migraine pain, immune cell activation and calcitonin gene-related peptide (CGRP) signaling, may be connected to understand how CGRP receptor antagonist migraine therapies work. The outcomes of these studies may not only reveal a mechanism underlying the therapeutic efficacy of CGRP antagonists but potentially novel targets and mechanisms to improve existing migraine therapies.

PI_NAMEs: ADI, TALIA  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Afferent Neurons;Anatomy;antagonist;Attenuated;Auras;Behavior;Behavioral;Behavioral Assay;Calcitonin;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;career;Caring;Cells;Cephalic;Cerebrospinal Fluid;Chronic;Classic Migraine;Clinical;clinically relevant;Coculture Techniques;cytokine;Data;Development;Disabling;Disease;drug action;Ensure;Event;experimental study;Fellowship;Flow Cytometry;Fluorescent in Situ Hybridization;Future;Goals;Headache;Hypersensitivity;Immune;immune activation;Immune Targeting;improved;in vivo;Inflammation Mediators;Inflammatory;intravenous administration;Macrophage;Macrophage Activation;mechanical allodynia;Mechanics;Mediating;Meningeal;Meninges;Mentors;Messenger RNA;Migraine;migraine treatment;minimally invasive;Modeling;Morphology;mouse model;Mus;Nervous System Disorder;neural;Neurologic;Neurologist;Neurology;Neurons;novel;optogenetics;Outcome;Outcome Study;Pain;pain behavior;Pain Measurement;pain reduction;Pain Research;Patients;Peptide Signal Sequences;Peptide Synthesis;Phenotype;Physicians;Physiology;Plasma;prevent;receptor;receptor expression;receptor-activity-modifying protein;Reporting;Research;Research Personnel;RNA;Role;Scientist;single-cell RNA sequencing;Spreading Cortical Depression;spreading depression;Structure of trigeminal ganglion;success;Technical Expertise;Testing;Time;Training;Treatment Efficacy;two photon microscopy;Work

PROJECT_TITLE: The role of meningeal immune cells in the efficacy of CGRP-based migraine therapies


NIH_SPENDING_CATS: Prevention

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative We propose to study the role of xenobiotic receptors and drug-metabolizing enzymes in drug-induced toxicological effects, the leading cause of treatment failure. We will develop and characterize novel compounds and determine their mechanisms and effects in preventing drug-induced toxicological effects and increasing intracellular drug accumulation. The results of our proposed studies will illustrate how drugs cause toxicological effects and will identify potential therapeutic approaches to prevent such toxicological effects and improve treatment efficacy.

PI_NAMEs: CHEN, TAOSHENG  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Adverse drug effect;Affect;Biological Availability;Cell model;Chemicals;Comprehension;constitutive androstane receptor;CYP3A4 gene;CYP3A5 gene;Cytochrome P450;design;Development;Diabetes Mellitus;Disease;drug disposition;drug efficacy;Drug Prescriptions;Drug resistance;Drug toxicity;Enzymes;flexibility;Genetic Transcription;Goals;Homeostasis;Human;human disease;improved;in vivo;inhibitor;innovation;Ligands;Malignant Neoplasms;novel;Nuclear Receptors;Outcome;Pharmaceutical Preparations;Pharmacotherapy;Post-Translational Regulation;posttranscriptional;pregnane X receptor;prevent;protein protein interaction;receptor;Regulation;Role;Technology;Therapeutic;Tissues;tool;Toxicology;Treatment Efficacy;Treatment Failure;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative Hepatitis C virus (HCV) infects at least 71 million people worldwide and is a major cause of liver cirrhosis and hepatocellular carcinoma. The proposed research addresses this major public health problem by developing a vaccine to optimize the presentation of conserved broadly neutralizing antibody and T cell epitopes that will lead to long-lasting B and T cell-mediated immunity, the leading contributors to the control of acute HCV infection. A multi-disciplinary approach is proposed to address the challenges of the high variability of this virus, and, if successful, our work will lead to a rationally designed HCV vaccine candidate that will help prevent infection and associated pathologies of HCV.

PI_NAMEs: ANDRIANOV, ALEXANDER ;FUERST, THOMAS R (contact);MARIUZZA, ROY A;OFEK, GILAD A;PIERCE, BRIAN G.;PLOSS, ALEXANDER ;SINGH, NEVIL JOHN

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Active Immunization;Acute Hepatitis C;Address;Adjuvant;Affinity;Alanine;alpha helix;Amino Acids;Animal Model;Antibodies;Antibody Response;Antigenic Diversity;Antigens;aqueous;B-Lymphocytes;Binding;Biochemical;Biological Models;Budgets;burden of illness;Cavia;CD81 gene;Cellular Immunity;Cirrhosis;Clinical;Clinical Trials;Complex;Cryoelectron Microscopy;Data;design;Development;efficacy testing;Enzyme-Linked Immunosorbent Assay;Epitopes;Evaluation;Face;Fibrosis;Formulation;Generations;Genome;Genotype;Glycoproteins;Goals;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;hepatitis C virus nucleocapsid protein;Human;humanized mouse;Hydrogels;Immune response;Immunity;Immunization;Immunize;Immunocompetent;immunogenicity;Immunologics;Individual;Infection prevention;insight;interdisciplinary approach;Lead;Liver;Liver Cirrhosis;Liver diseases;long term memory;Macaca;macromolecule;Maps;Medical;Membrane;Modeling;Modification;Molecular Conformation;Monoclonal Antibodies;mouse model;Mus;nanoparticle;neutralizing antibody;Pathology;Persons;Polymers;polyphosphazene;preservation;prevent;Primary carcinoma of the liver cells;programs;Property;protective efficacy;Proteins;Protocols documentation;Public Health;rational design;receptor binding;Research;Resolution;response;Risk;scaffold;Scanning;self assembly;Serology;Serum;Side;Specificity;Structure;System;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;tissue resident memory T cell;United States National Institutes of Health;Vaccinated;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;Variant;Viral;Virus;virus envelope;waiver;Work

PROJECT_TITLE: Rational design and efficacy testing of vaccines against HCV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(02)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PI_NAMEs: SHAH, VIJAY H. (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Alcohol consumption;Alcohols;Attenuated;Beta Cell;Binding;Binding Proteins;Biological Assay;cell motility;Cellular biology;chromatin modification;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Deposition;Development;Endosomes;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;EZH2 gene;fibrogenesis;Fibrosis;Gene Activation;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Transcription;Goals;Growth Factor;Hepatic Stellate Cell;Hi-C;histone methylation;histone methyltransferase;Histones;Human;Image;In Vitro;in vivo;innovation;Instruction;Insulin;Investigation;knock-down;Knock-out;Liver;Liver Fibrosis;liver injury;Lobule;Magnetic Resonance Elastography;Mediating;migration;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;parent grant;PDGF receptor tyrosine kinase;Peptides;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;Play;Population;Portal vein structure;Process;Production;Proliferating;promoter;protein transport;Proteins;Receptor Signaling;recruit;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Techniques;Testing;therapeutic target;trafficking;transcriptome sequencing;Transferase;Transforming Growth Factor beta;Vesicle

PROJECT_TITLE: Molecular Mechanisms of Liver Fibrosis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: We recently found that IL-4, a cytokine mostly associated with allergic disease is produced within lung tumor lesions and controls the development and the differentiation of myeloid cells in the bone marrow and lung lesions. In this grant, we will determine the mechanisms controlling IL-4 production in lung lesions and the downstream consequences of IL-4 signaling on bone marrow myelopoiesis and myeloid cell differentiation in lung tissues. We have also started a clinical trial to treat lung cancer patients with combined IL-4R receptor alpha and PD-1 antibody blockade providing a unique opportunity in this grant to measure the impact of IL-4 receptor signaling blockade on human circulating and lung tissue infiltrating myeloid cells.

PI_NAMEs: MARRON, THOMAS URBAN;MERAD, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Affect;Allergic Disease;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Antigen-Antibody Complex;arm;Basophils;Biopsy Specimen;Blocking Antibodies;Blood specimen;Bone Marrow;Cancer Etiology;Cancer Patient;Caring;Cell Differentiation process;Cell Physiology;cell type;Cells;Cessation of life;Chimera organism;Clinical Trials;Coculture Techniques;Coupled;Cre driver;Cues;cytokine;Cytokine Signaling;Data;Dendritic Cells;design;Development;Disease;effective therapy;Emergency Situation;epigenomics;epithelial injury;Epithelium;Exhibits;Experimental Models;FDA approved;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Grant;granulocyte-monocyte progenitors;high dimensionality;Human;Immune;Immune response;Immunity;Immunologics;Immunophenotyping;Immunosuppression;Immunotherapy;imprint;in vivo;Infiltration;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Lesion;Leucocytic infiltrate;Location;Lung;Lung Adenocarcinoma;lung lesion;Lung Neoplasms;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Mediating;Minority;Molecular;monocyte;mouse model;Mucous Membrane;multiplexed imaging;Mus;Myelogenous;myeloid cell development;Myeloid Cells;Myeloid Progenitor Cells;Myeloid-derived suppressor cells;Myelopoiesis;neoplastic cell;neutrophil;Non-Small-Cell Lung Carcinoma;novel;Outcome;Parasitic infection;Pathway interactions;Patients;PD-1 blockade;PD-L1 blockade;Population;Population Heterogeneity;prevent;Production;progenitor;programs;Reagent;receptor;Receptor Signaling;Refractory;Regulation;Relapse;repaired;response;restraint;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Source;Spatial Distribution;stem cells;Structure of parenchyma of lung;Surface;synergism;System;targeted treatment;Testing;Th2 Cells;Therapeutic Equivalency;Therapeutic Intervention;Tissues;transcriptomics;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;tumor-immune system interactions;Unresectable;Work

PROJECT_TITLE: Type 2 immunity: a primitive response to epithelial injury that shapes bone marrow and lung myeloid crosstalk

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]