NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cerebral Palsy;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Osteoarthritis;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Rehabilitation;Telehealth

PROJECT_TERMS: Academia;Academy;Address;Affect;Algorithms;Ambulatory Monitoring;American;Area;Award;Awareness;Behavioral Model;Binding;Biomechanics;Biomedical Computing;Biomedical Engineering;biomedical scientist;Biomedical Technology;Cellular Phone;Cerebral Palsy;Characteristics;Clinic;Clinical;Clinics and Hospitals;Collaborations;Communication;Communities;Computer software;Congresses;coral;cost;Data;Data Science;Data Set;Degenerative polyarthritis;Diagnosis;Disease;Documentation;Educational workshop;Event;Exercise;experience;Exposure to;Fostering;functional improvement;Future;Gait;Goals;handheld mobile device;Health;health goals;Image;improved;improved mobility;Individual;individualized medicine;Industry;Infrastructure;innovation;insight;Institution;interest;International;Intervention;Joints;Journals;kinematics;Leadership;live stream;Locomotion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Manufacturer;Measurement;Measures;member;Metabolic;mHealth;mhealth interventions;mobile computing;mobile sensing;mobile sensor;Modeling;Monitor;Motion;Movement;multidimensional data;Muscle;new technology;Newsletter;Obesity;online resource;Orthopedics;Parkinson Disease;Participant;Patients;Persons;Physical activity;Physical Medicine;program dissemination;programs;Property;Publishing;Records;Rehabilitation Outcome;rehabilitation research;rehabilitation science;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Resources;Rotation;Running;sensor technology;Series;Services;skills;social media;societal costs;Software Tools;success;Surgeon;symposium;technology training;terabyte;Time;tool;Training;Training Programs;Travel;United States National Institutes of Health;user-friendly;Video Recording;wearable data;wearable sensor technology;web site;Woman

PROJECT_TITLE: Technology Training and Dissemination


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Breathing is a critical physiological behavior that supports life from our first moment to our last. Anatomically and genetically diverse populations of neurons in the brainstem are responsible for both the effortless persistence of breathing from birth to death, and the flexible control that allows for complex behaviors like feeding and vocalizing. This project utilizes novel experimental techniques to unravel how neural populations distributed throughout the brainstem work together and how they are reconfigured to control different breathing frequencies and gasping.

PI_NAMEs: BUSH, NICHOLAS EDWARD (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TITLE: Dynamic switching in the brainstem: a spatiotemporal mechanism for the neural control of breathing


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NEW HAVEN

ORG_DEPT: ORTHOPEDICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This grant will prepare Biomedical Engineering seniors from diverse backgrounds with the knowledge, skills and perspectives to be able to develop and translate safe biomedical technologies to improve public health. Students will learn how to design a medical device within a multifunction team following the biodesign innovation process, starting with student identified needs assessment focusing on preventing medical device failures and project identification originated within a summer clinical immersion, and completing the course with a functioning prototype. In addition, in a team-based environment, the class teaches students advanced medical device failure analysis so that students understand modes of failure, are able to design safe reliable medical devices and techniques for simulating and evaluating failures.

PI_NAMEs: TOMMASINI, STEVEN M;WIZNIA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;Adverse event;Biocompatible Materials;Biomedical Engineering;Biomedical Technology;career;Caring;Cell Nucleus;Clinical;Clinical Engineering;Collaborations;commercialization;Complex;Complication;Computer software;cost;design;Device Designs;Device Safety;Devices;Diagnostic;Ecosystem;Educational Curriculum;Educational process of instructing;Elements;Engineering;Environment;Equipment Malfunction;experience;fabrication;Faculty;Failure;falls;Fellowship;Finite Element Analysis;Frustration;Future;Goals;Grant;hazard;health care delivery;Health Professional;Healthcare;Healthcare Systems;Hour;Human;image processing;Immersion;Implant;improved;improved outcome;indexing;innovation;instrumentation;interest;invention;Journals;Knowledge;Learning;lectures;Machine Learning;Medical;medical complication;Medical Device;Medical Device Designs;Medical Device Failures;Medical Errors;Medical Research;medical specialties;Medical Technology;member;Mentors;Modeling;Needs Assessment;novel;Nurses;online course;Orthopedics;Pain;Paper;Participant;Patient-Focused Outcomes;Patients;Physicians;prevent;Procedures;Process;programs;project-based learning;prototype;Public Health;Publishing;PubMed;Regulatory Affairs;research and development;Resources;responsible research conduct;Risk Management;Rotation;Scientist;Series;simulation;skills;Source;Structure;Students;summer student;Surgeon;Surgical Error;Techniques;technological innovation;Technology;tool;Training;Translating;undergraduate student;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Medical Device Design and Innovation; Orthopaedic Implant Failure Analysis and Redesign


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Narrative A high-level spinal cord injury (SCI) interrupts supraspinal regulation of sympathetic activity to the heart. The imbalance of sympathetic and parasympathetic outflow leads to cardiac and hemodynamic disorders. In this project, we will determine whether integration of transplanted raphe nucleus-derived neural progenitor cells (RN-NPCs) or human induced pluripotent stem cell (iPSC)-derived serotonergic progenitors with spinal cord circuitry reestablishes serotonin regulation to improve cardio-electric transduction. Meanwhile, we will test whether combining RN-NPC transplants with exercise further enhances the reconstruction of sympathetic regulation to restore cardiac activity, hemodynamics, and autonomic dysreflexia after SCI. The results will provide vital guidance to future clinical therapeutics.

PI_NAMEs: HOU, SHAOPING  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult women;Animals;Arrhythmia;Autonomic Dysreflexia;Axon;axon regeneration;Blood Pressure;Brain Stem;Cardiac;Cardiovascular system;Cells;Chronic;Clinical;colorectal distension;combinatorial;comorbidity;Control Groups;Coronary heart disease;Disease;Dobutamine;effective therapy;Embryo;Embryo Transfer;Exercise;Fostering;FRAP1 gene;Functional disorder;Future;Genetic;Green Fluorescent Proteins;Growth;Heart;Heart Diseases;Heart failure;heart function;heart rate variability;hemodynamics;Hindlimb;Histologic;human induced pluripotent stem cells;Hypotension;Implant;improved;Inbred F344 Rats;Incidence;Injury;insight;Interneurons;Interruption;Intervention;Kidney;Lesion;Longitudinal Studies;Modeling;mortality risk;Myocardial dysfunction;nerve stem cell;Neurons;neurotrophic factor;novel;Nuclear Pore Complex;Orthostatic Hypotension;Pathway interactions;pharmacologic;Production;progenitor;raphe nuclei;Rat Transgene;Rattus;receptor;reconstitution;reconstruction;Recovery;Recovery of Function;recruit;Regulation;Reporting;Rest;Role;serotonergic regulation;Serotonergic System;Serotonin;Signal Transduction;Site;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord transection injury;Stem cell transplant;stem cells;Synapses;Testing;Thallium Myocardial Perfusion Imaging Stress Test;Therapeutic;Therapeutic Intervention;translational potential;Transplantation;Western Blotting

PROJECT_TITLE: Combining Serotonergic Neural Progenitor Transplantation and Exercise to Improve Cardiac Disorders and Autonomic Dysreflexia After Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: KANSAS CITY

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH Bladder cancer (BCa) is a common solid tumor with poor outcomes in advanced disease with the most significant prognostic factor being the presence of metastasis. While much work has been done on identifying the presence of metastatic tumor cells in lymph nodes, little research currently explores the mechanisms that govern BCa progression to metastasis. These studies will define the role of mitochondrial DNA in BCa metastasis and open an entirely new area of development for biomarkers, therapeutics, and targeted preventative medicine.

PI_NAMEs: TAYLOR, JOHN A (contact);WELCH, DANNY R.

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: advanced disease;Advanced Malignant Neoplasm;Affect;angiogenesis;Apoptosis;Area;Basic Science;Biological Markers;Biology;biomarker development;Breast;C3H/HeN Mouse;cancer cell;Cancer cell line;Cancer Model;Cell Culture Techniques;Cells;chemical carcinogen;Complement;Credentialing;Data;Development;Diagnosis;Disease;DNA;Elements;Event;Exhibits;experience;experimental study;Female;Frequencies;Future;Genetic;Genotype;Goals;human disease;improved;Infiltration;Inflammatory;Inherited;Intravenous;Intrinsic factor;Laboratories;laser capture microdissection;lymph nodes;Malignant Breast Neoplasm;Malignant neoplasm of urinary bladder;Measures;Mediator;Medical;Melanoma;Metastatic Neoplasm to the Lung;Mitochondria;Mitochondrial DNA;Modeling;mouse model;Mouse Strains;Mus;Neoplasm Metastasis;neoplastic cell;Nitrosamines;novel;Nuclear;Operative Surgical Procedures;Outcome;Pathogenicity;Pathway interactions;Patients;Phenotype;Predisposition;Prevention Research;Preventive Medicine;Primary Neoplasm;Prognostic Factor;programs;Proliferating;Proteins;Public Health;Research;response;Ribosomal RNA;Role;Sampling;Signal Transduction;Solid Neoplasm;Target Populations;Therapeutic;Tissues;transcriptome sequencing;Transfer RNA;Transgenic Mice;tumor;tumor initiation;tumor progression;tumorigenesis;Tumorigenicity;Variant;Work

PROJECT_TITLE: Regulatory Role of Mitochondrial DNA in Bladder Cancer Progression

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE The proposed research plan will help define a poorly understood mechanism by which the PKD1/TRPP2 complex is activated by a secreted ligand. This information will enable future research towards the design of new therapeutic targets for ADPKD.

PI_NAMEs: HARDY, EMILY P (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Autosomal Dominant Polycystic Kidney;Binding;Biochemistry;Biological Assay;C-terminal;Cations;Cells;Complex;Cystic Kidney Diseases;desensitization;design;Disease;effective therapy;Event;extracellular;Future;G-Protein-Coupled Receptors;Gene Proteins;Genetic Diseases;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;human disease;In Situ;insight;Investigation;Ion Channel;Knowledge;Lead;Ligands;Mediating;Modeling;Molecular Biology;Mus;Mutation;new therapeutic target;novel;Outcome;patch clamp;Patch-Clamp Techniques;Pathogenesis;prevent;Protein Binding Domain;Proteins;receptor;receptor-mediated signaling;Regulation;Research;response;Role;Signaling Protein;Testing;training opportunity;WNT Signaling Pathway

PROJECT_TITLE: WNT signaling in Autosomal Dominant Polycystic Kidney Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The role of splice factors in regulating interferon (IFN) responses is unclear. Here, we discover a splice factor CELF2 suppressing IFN expression. These findings could have a significant impact on IFN-mediated autoimmunity.

PI_NAMEs: SAVAN, RAM  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 7SL RNA;adaptive immune response;ADAR1;Alternative Splicing;Autoimmunity;Biogenesis;Cells;Defect;Development;Disease;DNA;Failure;Family member;Generations;Genes;Genetic Transcription;Goals;Immune;immune RNA;Immune signaling;Infection;Innate Immune Response;Interferon Activation;Interferon Suppression;Interferon Type I;Interferons;Ligands;Mediating;Messenger RNA;monocyte;Natural Immunity;new therapeutic target;novel;Nucleic Acids;Pathogen detection;pathogenic virus;Pathology;Pathway interactions;Phenotype;Play;Post-Transcriptional Regulation;programs;Proteins;Pseudogenes;receptor;Receptor Activation;Regulation;Reporting;response;RNA;RNA Editing;RNA Splicing;RNA-Binding Proteins;Role;sensor;Signal Recognition Particle;Signal Transduction;Testing;Tissues;Toll-like receptors;Viral;viral detection;viral RNA;Virus Diseases;Work

PROJECT_TITLE: The splicing factor CELF2 suppresses RNA ligands sensed by RIG-I-like receptor


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Failure to maintain asthma symptom control is a major cause of lost school and workdays. This project aims to evaluate the role of the Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) signaling pathway in the pathobiology of poor asthma control. We will use genomics to define the pathway components most pertinent in asthma control. We will evaluate a soluble form of TREM1 (sTREM1) as a potential biomarker of asthma control. We will also evaluate a TREM1 inhibitor as a potential non-steroidal therapy for asthma management.

PI_NAMEs: MILLSTEIN, JOSHUA ;RABY, BENJAMIN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;affection;Air Pollution;airway inflammation;Allergens;allergic airway inflammation;Amplifiers;antagonist;Asthma;asthma exacerbation;asthma inhaler;asthmatic;asthmatic patient;Attenuated;Biological Markers;CD14 gene;Cell surface;Cell Surface Receptors;Cells;Child;Chronic;Classification;Clinical;cohort;Crohn's disease;Data;Dendritic Cells;Deterioration;Endotoxins;Environmental Exposure;Environmental Risk Factor;Europe;Event;Failure;first-in-human;Future;Gene Expression;Gene Expression Profile;Genetic;genetic signature;genetic variant;Genomic approach;Genomics;Goals;Grant;Hospitalization;Individual;Individual Differences;individual variation;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Macrophage;Measures;Mediating;Mediation;Medical Care Costs;Modeling;Molecular;monocyte;mouse model;Myeloid Cells;North America;Pathway interactions;patient population;Patients;Pattern;Pattern recognition receptor;peripheral blood;Pharmaceutical Preparations;pharmacologic;Phenotype;Plasma;Play;potential biomarker;pre-clinical;prevent;programs;Pyroglyphidae;receptor;Reporting;Reproducibility;Research;Resolution;Role;Sampling;Schools;Severities;Signal Pathway;single-cell RNA sequencing;Symptoms;T cell response;Testing;Therapeutic;Time;TLR4 gene;TNF gene;transcriptome sequencing;treatment response;Virus Diseases;Work;young adult

PROJECT_TITLE: Integrative Genomics of Acute Asthma Control

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Alzheimer's disease is one of the most prevalent and impactful diseases in the United States and throughout the world. Currently no effective treatments or therapeutics that slow or stop Alzheimer's disease are available. This project seeks to determine the mechanism by which changes in the gut microbiota and gut permeability can modify the pathogenesis of Alzheimer's disease. The proposed work is expected to result in new information that can inform the development of new therapeutic strategies or treatments for Alzheimer's disease.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA (contact);REY, FEDERICO E;ULLAND, TYLER KENT

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;amyloid pathology;Antibody titer measurement;Automobile Driving;Biological Assay;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Cerebrospinal Fluid;Chemicals;Circulation;Clinical;Cognitive;cohort;Collection;Dementia;Derivation procedure;Development;Disease;Disease Progression;effective therapy;experimental study;FRAP1 gene;Gastrointestinal tract structure;Germ-Free;glial activation;Gnotobiotic;Goals;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;gut microbiota;Homeostasis;Human;Immune response;Immune system;Impairment;indexing;Individual;inflammatory marker;Infrastructure;Innate Immune Response;intestinal barrier;Intestinal permeability;Intestines;Lactulose;Leukocyte L1 Antigen Complex;Link;Lipopolysaccharides;Liquid substance;macromolecule;Mannitol;Measures;Mediating;metagenome;Methods;Microbe;microbial;Microbiology;microbiome composition;mouse model;Mucous body substance;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuropathology;novel therapeutic intervention;older adult;Participant;participant enrollment;Pathogenesis;Pathology;Permeability;Persons;Play;Positron-Emission Tomography;Process;prospective;Publishing;Reporting;Research;Resources;Role;Sampling;Signal Transduction;Sodium Dextran Sulfate;stool sample;success;System;systemic inflammatory response;tau Proteins;Testing;Therapeutic;Time;United States;virtual;Wisconsin;Work

PROJECT_TITLE: Gut barrier function in Alzheimer’s disease


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative: Our project tackles the heterogeneity in individuals at high-risk for psychosis which has been a long-standing challenge in the field of psychiatry. This challenge has hampered investigation and therapeutic intervention for decades. Using objective biomarkers to parse this heterogeneity in the early phase of the illness, we seek to describe this population and its subgroups, predict outcome, and provide the basis for personalized early therapeutic interventions for the purpose of preventing the illness before it arises.

PI_NAMEs: YASSINE, WALID  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Adopted;affective psychoses;American;analytical method;Biological;biological heterogeneity;Biological Markers;biotypes;Brain;brain based;Categories;Chronic;Clinical;clinical heterogeneity;clinical high risk for psychosis;clinical phenotype;clinically relevant;Cluster Analysis;Cognitive;comparative;Confusion;Data;Data Set;Development;Diagnosis;Diagnostic;Disease remission;Early Intervention;early psychosis;Electrophysiology (science);follow-up;Frequencies;Functional disorder;Functional impairment;functional outcomes;Future;Goals;Heterogeneity;high risk;high risk population;Image;Individual;Intervention;Investigation;Longitudinal Studies;Measures;Modeling;multimodal data;multimodality;Neurobiology;neuroimaging;non-affective psychoses;Outcome;Outcome Measure;outcome prediction;Patients;Pattern;Phase;phenotypic data;Population;prevent;Prevention;prospective;Psychiatry;Psychopathology;Psychoses;psychosis risk;Reporting;Research;Risk Factors;Sampling;Schizophrenia;Stratification;Subgroup;supervised learning;Symptoms;Syndrome;Therapeutic Intervention;treatment response;Validation;Variant;Work

PROJECT_TITLE: Identification of Distinct Biotypes in Clinical High Risk for Psychosis State Using Objective Brain-Based Biomarkers

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Immunotherapy;Lupus;Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Autoreactive B cells play central roles in the pathogenesis of systemic lupus erythematosus (SLE). This study investigates a novel bispecific antibody-based immunotherapy designed to engage T lymphocytes to selectively destroy autoreactive B cells in SLE. The goal of this proposal is to generate precise, effective, and safe immunotherapies to treat autoimmunity without impairing the normal, protective B cell pool in SLE.

PI_NAMEs: ANDRADE, FELIPE ;KONIG, MAXIMILIAN FERDINAND (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Alleles;Antibodies;Antigens;Antinuclear Antibodies;Autoantibodies;Autoimmune Diseases;Autoimmunity;Autologous;autoreactive B cell;autoreactivity;B cell therapy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Assay;Biological Models;Bispecific Antibodies;Bite;cancer cell;CAR T cell therapy;Cardiolipins;CD19 gene;CD3 Antigens;Cell Compartmentation;Cell Line;Cell Separation;Cells;Clinical Trials;crosslink;cytotoxic;design;Development;Disease;Disease remission;ds-DNA;efficacy testing;efficacy validation;Engineering;Exclusion;fighting;Flow Cytometry;Foundations;Goals;Human;Human Engineering;Immunoglobulin G;Immunoglobulin Idiotypes;Immunoglobulins;Immunotherapy;Impairment;in vitro Model;Individual;Infection;infection risk;innovation;Ku70 protein;Life;Lupus;Lupus Erythematosus;Mediating;Memory;Memory B-Lymphocyte;Monoclonal Antibodies;Morbidity - disease rate;mortality;MS4A1 gene;Muromonab-CD3;novel;novel therapeutic intervention;Nuclear;Nucleic Acids;pathogen;Pathogenesis;Pathogenicity;Patients;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;personalized immunotherapy;Pharmaceutical Preparations;Plasma Cells;Play;Population;Precision therapeutics;preservation;primary endpoint;Proteins;Reaction;Refractory;Research Project Grants;rituximab;Role;Serum;Specificity;Structure of germinal center of lymph node;Surface Antigens;Surface Plasmon Resonance;System;Systemic Lupus Erythematosus;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Uses;Tissues;treatment strategy;vaccine response;Work

PROJECT_TITLE: Precision immunotherapies targeting the 9G4 idiotype in lupus erythematosus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Mental Health;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: This research is highly relevant to public health because of the rapidly growing population of childhood cancer survivors and the increasing burden of late effects from therapy on survivors, families, and the healthcare system. Determining specific medical and neurocognitive late effects that increase psychosocial morbidity, as well as protective factors, will inform more effective interventions to optimize quality of life in children affected by early onset cancer. This is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will extend human life and help to reduce the burdens of illness and disability.

PI_NAMEs: GERHARDT, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: GUIDA, JENNIFER LYN

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adult;Affect;Affective;Age;Behavior;Behavioral;Brain;Brain Injuries;Brain Neoplasms;Buffers;burden of illness;Caring;Central Nervous System;Central Nervous System Diseases;Child;Child Rearing;Child Welfare;childhood cancer survivor;Childhood Cancer Treatment;Cognitive;cost;Cranial Irradiation;Data;design;Development;developmental psychology;Diagnosis;disability;Distress;Early Diagnosis;early onset;educational atmosphere;effective intervention;Emotional;emotional distress;Employment;Ensure;Environment;experience;Failure;Family;Female;Friends;Friendships;Goals;Happiness;Healthcare Systems;Hearing;heuristics;high risk;Home visitation;Hospitalization;Human;Impairment;improved;improved outcome;Individual;informant;Intervention;Intrathecal Chemotherapy;Knowledge;Late Effects;Life;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Marriage;Mediating;Medical;Mission;Modeling;Morbidity - disease rate;Nature;Neuroblastoma;Neurocognitive;Neurocognitive Deficit;neurotoxic;Nursery Schools;Organ;Outcome;Parents;Pediatric Oncology;peer;Population;Positioning Attribute;Predictive Factor;prevent;primary outcome;Problem Solving;protective factors;psychosocial;psychosocial adjustment;psychosocial outcome;Public Health;Quality of life;Race;Research;Residual state;resilience;Resources;Retinoblastoma;Risk;Risk Factors;Role;School-Age Population;Schools;Second Primary Cancers;sex;Site;skills;social;social cognition;Social Development;Social isolation;social neuroscience;Social Values;Subgroup;success;Survivors;survivorship;teacher;Time;Toxic effect;United States National Institutes of Health;Victimization;Vision;Vulnerable Populations;Work;young cancer survivor

PROJECT_TITLE: Psychosocial Risk in Young Survivors of Early Onset Pediatric Cancer: The Role of Physical and Neurocognitive Late Effects

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This project is relevant to public health because it explains how scleral remodeling is regulated during myopia development and evaluates efficacy/safety of the first pharmaceutical treatment modality that accelerates natural crosslinking for myopia control. Our mechanism and treatment discoveries will likely translate to humans due to the usage of a close-to-primate animal model and may provide a new and safe treatment to battle the myopia epidemic representing a significant global health concern.

PI_NAMEs: GRYTZ, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Acceleration;ADAMTS;Adolescent;Adult;Adverse effects;Age;aggrecan;Aging;Animal Model;Animals;Biological Markers;Biomechanics;Cartilage;Childhood;Clinical;Collagen;Collagen Fiber;Copper;crosslink;Development;Disease;efficacy evaluation;Epidemic;Eye;Eye Development;Fiber;genipin;Glaucoma;global health;Goals;Grant;healthcare burden;Human;Hyperopia;Injections;innovation;insight;interstitial;juvenile animal;Lead;mature animal;Measurement;Mechanical Stress;Mechanics;Mediating;Messenger RNA;Modality;Modeling;Myopia;nanoindentation;normal aging;Peptide Hydrolases;Peripheral;Pharmacologic Substance;Play;Polarization Microscopy;Population;Predisposition;Prevalence;prevent;Primates;Property;Protein-Lysine 6-Oxidase;Proteoglycan;Public Health;Quality of life;Recovery;Reporting;Retina;Retinal Detachment;Risk;Role;Safety;Sampling;Sclera;Signal Transduction;Site;Slide;Sodium Chloride;Spatial Distribution;Testing;Tissues;tool;Translating;Treatment Efficacy;treatment optimization;Tupaiidae;Vision;Water

PROJECT_TITLE: Scleral Remodeling in Myopia

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Hematology

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Von Willebrand Factor is a circulating blood protein important for staunching bleeding at sites of endothelial injury. Von Willebrand Disease (VWD), the most common bleeding disorder worldwide, is due to mutations in VWF, causing variable degrees of excess bleeding. To inform therapeutic efforts to alleviate morbidity from VWD, the proposed research will expand our structural understanding of the tubule VWF adopts intracellularly, a potential target for modulating VWF’s hemostatic function, before secretion into blood.

PI_NAMEs: ANDERSON, JACOB R (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: 3-Dimensional;Adopted;Architecture;Binding;Blood;Blood Coagulation Disorders;Blood Platelets;Blood Proteins;Blood Vessels;C-terminal;Cells;cleavage factor;clinically relevant;Coagulation Process;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Cysteine;Data;Data Collection;Development;dimer;Dimerization;Disease;disorder subtype;disulfide bond;Disulfide Linkage;Disulfides;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Engineering;Environment;experience;Factor VIII;Failure;Fellowship;Generations;Golgi Apparatus;Head;Hematological Disease;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;In Situ;In Vitro;Inherited;Injury;insight;Length;light scattering;Link;Maps;Mediating;Missense Mutation;model building;Modeling;Molecular;Molecular Structure;monomer;Morbidity - disease rate;Mutation;Negative Staining;novel;Peptide Hydrolases;Physicians;Play;Positioning Attribute;pre-doctoral;Process;Proteins;reconstruction;Research;Resolution;Role;Scientist;Series;Site;Structure;Tertiary Protein Structure;Testing;Therapeutic;Thinness;Thrombosis;Time;tomography;Training;Umbilical vein;Visualization;von Willebrand Disease;von Willebrand Factor;Weibel-Palade Bodies;Work

PROJECT_TITLE: Structure and Function of the VWF Helical Tubule Required for Hemostasis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: WORCESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Epidemiological data suggest that traumatic brain injury (TBI) represents an important environmental risk factor for several devastating neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) for which no effective therapies are available. We and others have reported that a genetically encoded program governed by the axon destruction factor SARM1 clearly promotes TBI-associated neurodegeneration and a role for SARM1 has also been proposed in ALS/FTD. Here we investigate the role of repetitive TBI in initiating pathology and determine whether the mechanisms linking TBI and ALS/FTD converge on the neurodegenerative pathway governed by SARM1 in search of a therapy.

PI_NAMEs: HENNINGER, NILS  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Ablation;Acceleration;ALS patients;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Astrocytes;Attenuated;Axon;axon injury;axonal degeneration;Bacterial Artificial Chromosomes;Behavior;Behavior assessment;Behavioral;Biological Assay;c9FTD/ALS;C9ORF72;Categories;Cells;Clinical;cognitive testing;Data;Defect;Dendritic Spines;Denervation;density;Deposition;Dipeptides;Disease;Disease Progression;effective therapy;Environmental Risk Factor;epidemiologic data;Epidemiology;Event;Evolution;experimental study;Fluorescent in Situ Hybridization;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Genetic;Genetic Risk;Glaucoma;Goals;Histologic;Immunohistochemistry;Impaired cognition;improved;Individual;Inherited;Injury;insight;Interleukin-1 beta;Intervention;Investigation;Link;Metabolic;Microglia;Microscopic;mild traumatic brain injury;Modeling;Molecular;molecular pathology;Morphology;Motor;Motor Cortex;motor impairment;Motor Neurons;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neuromuscular Junction;Neuronal Injury;Neurons;neuropathology;neurotoxic;Nicotinamide adenine dinucleotide;Onset of illness;Pathologic;Pathology;Pathway interactions;Patients;Penetration;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;preservation;Process;programs;protein activation;protein TDP-43;Reporting;Research;response;Risk;Risk Factors;RNA;Role;sham surgery;sporadic amyotrophic lateral sclerosis;Sterility;Stimulus;Stress;Temporal Lobe;Testing;therapeutic target;Time;Transcript;Transgenic Organisms;Translating;Traumatic Brain Injury;Variant;Western Blotting

PROJECT_TITLE: Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal Dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Kidney Disease

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chronic kidney disease is a progressive, life-altering condition characterized by substantial burden, increased health care costs, and disproportionate prevalence in older adults. Because older adults often require support from family care partners to self-manage chronic disease, it is critical to acquire an understanding of how to best support both patients and their care partners as they work together to manage the full course of chronic kidney disease. This proposal leverages existing resources, uses multi-method approaches, and proposes data collection to understand the different ways in which older patient-family care partner dyads work together to manage chronic kidney disease over time and the impact of shared disease management on health and well- being at both the individual- and dyad-level; this information will then be used to adapt and test the feasibility of a novel, family-centered intervention designed to jointly benefit patients and family care partners.

PI_NAMEs: DEPASQUALE, NICOLE  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Area;Awareness;Board Certification;burden of illness;Cancer Patient;Capsicum;career;career development;Caring;Chronic Disease;Chronic Kidney Failure;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Complex;cost;Data;Data Analyses;Data Collection;Dementia;depressive symptoms;Deterioration;Development;Dialysis procedure;Disease;Disease Management;Disease Progression;Doctor of Philosophy;Educational Status;Effectiveness;effectiveness trial;Elderly;Epidemiologist;evidence base;experience;Family;Family Study;family support;Feasibility Studies;feasibility testing;Fostering;Foundations;Funding;Goals;Grant;Health;Health Care Costs;Health Policy;health related quality of life;Health Services;Human Development;human old age (65+);improved;Individual;insight;Internist;Intervention;intervention refinement;Interview;Kidney Failure;Kidney Transplantation;Leadership;Life;Longitudinal Studies;medical schools;member;Mentors;Methodology;Methods;Modeling;Modification;multidisciplinary;multiple chronic conditions;Nature;Nephrology;novel;older adult;older patient;Outcome;Patient Care;Patients;Pattern;Personal Satisfaction;Prevalence;prevent;Process;Process Measure;professor;Psychologist;Psychology;psychosocial;Public Health;Qualitative Research;Quasi-experiment;recruit;Renal function;Reporting;Research;Research Institute;Research Methodology;Research Personnel;Resources;Science;Self Management;Severity of illness;social;social science research;societal costs;Sociology;Structure;success;Teacher Professional Development;Testing;theories;therapy design;Time;Training;Training Programs;Universities;Work;Writing

PROJECT_TITLE: Supporting Patients and Family Care Partners to Manage Chronic Kidney Disease Together

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE This study seeks to understand how geographic barriers to accessing tuberculosis services affect diagnostic delay and incomplete treatment in middle-income country urban settings. It also explores how tuberculosis programs can improve diagnosis and treatment by helping individuals and communities overcome access barriers.

PI_NAMEs: JENKINS, HELEN E. (contact);YUEN, COURTNEY M.

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Affect;Area;Award;Catchment Area;Cause of Death;Censuses;Characteristics;Cities;Communicable Diseases;Communities;Country;Data;design;Diagnosis;Diagnostic;Diagnostic Services;Disease;economic disparity;economic indicator;effective therapy;Employment Status;Equation;Evidence based treatment;experimental study;Face;geographic barrier;Geography;Goals;Health;health care availability;Health care facility;Health Services Accessibility;high risk;improved;Incidence;Income;Individual;innovation;Intervention;Knowledge;Measures;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Network-based;Outcome;Participant;Patients;Persons;Peru;poor health outcome;preference;prevent;programs;Research;Research Priority;research study;Risk;Sampling;Services;sex;simulation;social disparities;socioeconomics;surveillance data;Surveys;Symptoms;therapy design;Time;tool;transmission process;Travel;Treatment outcome;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;United States National Institutes of Health;urban setting;Visit

PROJECT_TITLE: Understanding and addressing geographic barriers to accessing TB services in a high-burden urban setting

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Idiopathic transverse myelitis (ITM) is a single immune mediated attack of the spinal cord leading to paralysis, numbness and bowel/bladder dysfunction. We found a genetic mutation in families with ITM and we propose to model this genetic mutation in cell culture and human research. Understanding how this genetic mutation causes alterations between the immune and nervous systems will provide important insights into the cause of the disease as well as mechanism to test new therapies.

PI_NAMEs: LEVY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Adult;Affect;Age;Age Distribution;American;Antigens;autoimmune pathogenesis;Autophagocytosis;biobank;Biological Markers;Bladder Dysfunction;Cell Culture Techniques;Cells;Central Nervous System;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;disability;Disease;DNA;DNA Sequence Alteration;Endosomes;exome sequencing;exosome;experimental study;extracellular vesicles;Family;Future;Genes;Genetic;Genetic Models;genetic variant;Goals;granulocyte;Human;Image;Immune;Immune response;Immune signaling;Immune system;Immunosuppression;Incidence;Inflammatory;insight;Integral Membrane Protein;Intestines;Link;Lipids;Lymphocyte;Mass Spectrum Analysis;Mediating;Medical;Membrane Proteins;men;meter;Modality;Molecular Mimicry;monocyte;Multivesicular Body;Mutation;Nervous System;Nervous System Physiology;Neurological disability;neuron component;Neurons;novel therapeutics;Numbness;Osteosarcoma;Paralysed;Pathogenesis;Pathway interactions;Patients;Peptide Sequence Determination;Peripheral;Persons;Polishes;Population;Predisposition;Prevalence;Production;Proteins;rare variant;Recording of previous events;Recycling;Research;Risk;Risk Factors;RNA;Role;Serology;Signal Pathway;Sister;Sorting;Spinal Cord;System;Systemic infection;Teenagers;Testing;Time;Transverse Myelitis;treatment response;Vacuolar Protein Sorting;Variant;Vesicle;Woman;Work

PROJECT_TITLE: The Immunopathogenesis of Familial Transverse Myelitis Due to Mutations in VPS37a

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Danionella cerebrum is a novel adult transparent vertebrate model that is in its infancy and provides an exciting opportunity to advance our understanding of dynamic and complex biological processes through non-invasive in vivo live imaging and optogenetic manipulations. This proposal outlines the strategy to build an infrastructure for the use of this model that includes the development of live imaging techniques, transgenic lines, DNA reagents, as well as methods for tissue injury of adult D. cerebrum. We will generate fluorescent and activity reporter transgenic animals for the study of immune-related processes involved in the development of, injury to, and disease progression in multiple organ systems.

PI_NAMEs: LAM, PUI YING  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Acceleration;adaptive immunity;addiction;Adult;Affect;age-related disease;Aging;Animal Model;animal old age;Animals;awake;Behavioral;Biological Models;Biological Process;Biology;body cavity;Body System;bone;Brain;Calcium;Cell Physiology;cell type;Cells;Central Nervous System;Cephalic;Cerebrum;Characteristics;Collection;Communities;comparative;Complex;cranium;Data;Data Set;Development;Disease;disease model;Disease Progression;DNA;Dorsal;Endothelial Cells;Environment;Equipment;Event;experience;experimental study;Female;Future;Gene Transfer Techniques;Genetic Engineering;genome editing;Goals;Heart;Heterogeneity;high resolution imaging;human disease;Image;imaging modality;imaging study;Imaging Techniques;Immune;immune cell infiltrate;Immune response;Immune system;Immunological Models;Immunology;improved;in vivo;in vivo imaging;in vivo Model;infancy;Inflammaging;Infrastructure;Injury;Institution;intravital imaging;Kidney;Knowledge;Label;Larva;Learning;Length;Light;Liver;Macrophage;male;Malignant Neoplasms;mature animal;Measures;Mechanics;Memory;Methods;Microglia;Microscopy;model organism;Modeling;Molecular;Mus;mutant;Names;Natural Immunity;Natural regeneration;Nature;Nerve Regeneration;Nervous System;Neurodegenerative Disorders;neutrophil;novel;Optics;optogenetics;Organ;Physiological;Plasmids;Play;Procedures;Process;Reagent;regenerative;Regenerative capacity;Regenerative research;Reporter;Research;Resolution;response;response to injury;Role;screening;sex;Sex Differences;small molecule;Study models;Systems Biology;Tail;Techniques;teleost;Testing;Therapeutic;Tissue imaging;tissue injury;tissue regeneration;Tissues;tool;transcriptomics;Transgenic Animals;Transgenic Organisms;two-photon;Vascular System;Vertebrates;Visualization;Work;wound healing;young adult;Zebrafish

PROJECT_TITLE: Danionella cerebrum as a transparent vertebrate adult model for studying immune-related biological processes and diseases

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: NEW YORK

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

ORG_STATE: NY

PHR: Narrative Sleep is a basic biological need and sufficient sleep is required for physical and mental well-being. Here we propose to investigate the molecules that accumulate in the brain to signal sleepiness. The identification of such molecules in the brain would reveal targets for the improvement of sleep and provide important insights into its neural regulation.

PI_NAMEs: SHAFER, ORIE T (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Animals;Automobile Driving;awake;Biological;Brain;candidate identification;Cardiovascular Diseases;Charge;circadian pacemaker;Coupled;Drosophila genus;Drowsiness;Epidemic;Exertion;experimental study;falls;fly;Future;Health;Human;improved;improvement on sleep;Inflammatory;insight;Investigation;Liquid Chromatography;MALDI-TOF Mass Spectrometry;Mechanics;Mediating;Mediator;Mental Health;Metabolic;Methods;model organism;Modeling;Molecular;Nature;Nervous System;Nervous System Disorder;neural;neuromechanism;neuroregulation;Performance;physical conditioning;Physiological;pressure;prevent;Process;Productivity;Recovery;response;Safety;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep regulation;Sleep Wake Cycle;Sleeplessness;Slow-Wave Sleep;social;Societies;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stress;System;tandem mass spectrometry;Time;Wakefulness;Well in self;Work;World Health Organization

PROJECT_TITLE: Identification of Sleep Substances in the Brain Using Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Viral infections bring about profound changes in the host cell, either as a means to enhance viral replication or as a consequence of the host anti-viral response. This project investigates the changes induced by herpes simplex virus infection on the host nuclear factors responsible for key steps in RNA processing. Understanding how these factors influence viral reproduction and spread may lead to new therapeutic approaches.

PI_NAMEs: WILSON, ANGUS C (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Adenosine;Anti-viral Response;Antibodies;base;Biogenesis;Biological Process;Catalysis;Cell Fractionation;Cells;Chemicals;Chromatin;Co-Immunoprecipitations;Code;Complex;Coupled;Coupling;Cytoplasm;DNA Polymerase II;Elements;Ensure;Environment;Epigenetic Process;Excision;Exons;Frequencies;Gene Expression;Genes;Genetic Transcription;Goals;Herpes Simplex Infections;Herpesvirus 1;Infection;inhibitor;innovation;insight;Knowledge;Location;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;mRNA Stability;Mutagenesis;novel therapeutic intervention;Nuclear;Nuclear RNA;Nucleic Acids;Pathway interactions;Pattern;Peptide Signal Sequences;Poly A;Poly(A) Tail;Poly(A)+ RNA;Polyadenylation;Polyadenylation Pathway;Positioning Attribute;Predisposition;premature;prevent;Productivity;promoter;Protein Biosynthesis;protein complex;Recording of previous events;recruit;Reproduction;Resources;RNA;RNA Polymerase II;RNA Precursors;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Sedimentation process;Signal Transduction;Site;Small Interfering RNA;Structure;Testing;Transcript;transcription termination;transcriptome;transcriptome sequencing;Translations;Untranslated Regions;Untranslated RNA;Viral;Viral Genes;Viral Proteins;Viral Regulatory Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Viral disruption of host transcriptome integrity

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The Behavioral Health of Venezuelan Families in Diaspora: A Cross-National Study of Migration-Related Stress and Resilience Project Narrative: Public Health Relevance Venezuelans are among the fastest-growing immigrant groups in the United States (US), filing two times the number of US asylum applications annually as citizens from any other country. Our preliminary research— coupled with surveillance statistics and front-line journalism—suggests that depression and alcohol misuse are very important challenges for this population, and that many Venezuelan crisis migrants are exposed to high levels of stress before and after migrating. This research will provide us with knowledge vital to addressing the needs of Venezuelan crisis migrant families, and will inform responses to future crisis migrations.

PI_NAMEs: MALDONADO-MOLINA, MILDRED M (contact);SALAS-WRIGHT, CHRISTOPHER PATRICK;SCHWARTZ, SETH J.

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Acceleration;Address;Adolescent;Age;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol use initiation;Area;Attitude;behavioral health;bilingualism;Buffers;Child;Chronic;Clinical;Colombia;community partners;Country;Coupled;depressive symptoms;design;Development;Discrimination;drinking;Economics;Educational workshop;Emigrations;Epidemiology;Ethnic Origin;Etiology;Exclusion;experience;Exposure to;Family;family influence;Florida;Future;Health Personnel;Home;Hunger;Hurricane;Immigrant;improved;insight;Interview;Journalism;Knowledge;Latin American;Latino;Lead;Life;Link;Longitudinal Surveys;Mental Depression;Methods;Migrant;migration;Outcome;Parents;Participant;Personal Satisfaction;Persons;Pilot Projects;Policy Maker;Population;Prospective Studies;protective factors;psychosocial;Psychosocial Stress;public health relevance;Publishing;Puerto Rican;recruit;Recurrence;Reporting;Research;Research Project Grants;resilience;Respondent;response;Risk;Risk Factors;Sampling;Scientist;social;statistics;Stress;stressor;theories;United Nations;United States;Venezuelan;Work;Youth


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: AMES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Regulators of small GTPases play a central role in tuning the strength of synaptic connections. The aims of this project focus on defining the activation mechanisms and allosteric regulation of a prominent negative regulator of both Ras and Rap signaling. The proposed research is relevant to public health because delineating the regulatory mechanisms of synaptic signaling is a prerequisite to developing therapeutics and biomarkers for the mental health disorders that arise from its dysfunction.

PI_NAMEs: UNDERBAKKE, ERIC STEVEN (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: activated Protein C;Affinity;Allosteric Regulation;Architecture;autism spectrum disorder;Biological Assay;Biological Markers;biophysical techniques;biophysical tools;Brain;Brain Diseases;C-terminal;C2 Domain;Characteristics;Chemicals;Communication;Complex;Computer Models;Coupled;crosslink;Cytoskeleton;Data;density;design;Deuterium;Development;Disease;Docking;Excitatory Synapse;Exhibits;Fluorescent Probes;Foundations;frontier;Functional disorder;Future;Glutamate Receptor;Goals;GTPase-Activating Proteins;Guanosine Triphosphate Phosphohydrolases;Holoenzymes;Human;Hybrids;Hydrogen;Intellectual functioning disability;Knowledge;Learning;link protein;Long-Term Potentiation;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;Memory;Mental disorders;Modeling;Molecular;Molecular Conformation;Molecular Neurobiology;Monomeric GTP-Binding Proteins;Movement;Multiprotein Complexes;Mutagenesis;Mutation;N-terminal;Neurons;Outcome;Pathway interactions;PH Domain;Phosphorylation;Phosphorylation Site;Play;postsynaptic;Protein Dynamics;Protein Footprinting;protein function;protein structure;Proteins;Proteomics;Public Health;ras GTPase-Activating Proteins;Research;restraint;Roentgen Rays;Role;scaffold;Schizophrenia;Shapes;Signal Transduction;Signaling Protein;Specificity;Spectrum Analysis;structural biology;structural determinants;Structural Models;Structure;Surface Plasmon Resonance;Synapses;Synaptic plasticity;Tail;Tertiary Protein Structure;Therapeutic;tool

PROJECT_TITLE: Defining the architecture and activation mechanisms of SynGAP

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Adolescents with single ventricle heart disease (SVHD) show brain injury in regions which impact cognition that can affect their academic achievement, self-care ability, quality of life, mortality, and morbidity. However, the potential processes that can contribute to brain changes in SVHD in cognitive regulatory areas are unclear, but may include hypoxemia from lower O2 saturation and reduced cerebral blood flow from lower cardiac output, resulting to impaired brain metabolites and antioxidant levels, and cerebral blood flow deficits in those areas, as well as altered serum biomarkers. The findings from this study will have potential implications for identifying effective interventions that could be implemented on large clinical trial to rescue/restore brain metabolites and cerebral blood flow, which could benefit cognitive health, as well as improve mortality and morbidity, academic performance, and increase quality of life in this high-risk patient population.

PI_NAMEs: KUMAR, RAJESH  (contact);PIKE, NANCY ANN

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Academic achievement;Adolescent;Affect;Angiotensins;Antioxidants;Area;arterial spin labeling;Astrocytes;Behavior Therapy;Biological Markers;Brain;brain dysfunction;Brain Injuries;Brain region;Brain Stem;brain tissue;C-reactive protein;Carbon Dioxide;Cardiac Output;Cardiovascular system;Cerebrovascular Circulation;Child;Choline;Chronic;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive control;Cognitive deficits;cognitive function;Complex;congenital heart abnormality;Contrast Media;Creatine;Defense Mechanisms;Diffusion;Dipyridamole;Disease;effective intervention;Energy Metabolism;Equilibrium;Etiology;Exercise;Fetus;Glutathione;gray matter;Health;high risk;Hippocampus;Hypoxemia;IL8 gene;Image;Imaging Techniques;Impairment;improved;Inflammatory;insight;Insula of Reil;Interleukin-1 beta;Interleukin-6;Learning;Link;Low Cardiac Output;Measures;mechanical circulatory support;Mediating;Membrane;Memory;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;Morbidity - disease rate;mortality;myoinositol;N-acetylaspartate;Neurons;Nonpharmacologic Therapy;Operative Surgical Procedures;Osmosis;Outcome;Oxidative Stress;Oxidative Stress Induction;palliation;patient population;Patients;Performance;Physiology;Pilot Projects;Play;Positron-Emission Tomography;Prefrontal Cortex;Process;Production;Proliferating;Pulse Oximetry;Quality of life;Radiation;Reactive Oxygen Species;Reporting;Reproducibility;Role;Schools;Self Care;Serum;Short-Term Memory;Single ventricle congenital heart disease;Site;spectroscopic imaging;Spectrum Analysis;tissue injury;Tissues;TNF gene

PROJECT_TITLE: Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart Disease

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE – Declines in cognitive function due to Alzheimer’s Disease threaten the independence and quality of life for many older adults. This project will provide valuable new information regarding a potential novel therapeutic strategy with strong potential for translation to humans. This approach targeting a highly-promising and underexplored area has important potential for improving late-life health.

PI_NAMEs: BUFORD, THOMAS W (contact);MCMAHON, LORI LYNN

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Address;Adrenergic Agents;Adrenergic Receptor;Age;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amino Acids;Amyloid beta-Protein;Angiotensin I;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;ANGPT1 gene;Anxiety;Area;Axon;Behavior;Behavioral Assay;Blood Pressure;Brain;brain health;Centers for Disease Control and Prevention (U.S.);Clinical;Cognition;cognitive function;cognitive performance;Data;Disease Progression;Dose;Drosophila genus;efficacious intervention;Encephalitis;Engineered Probiotics;experience;Fluid Balance;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Modified;Genetic Engineering;Gliosis;granule cell;gut-brain axis;Health;high risk;Hippocampus;Histology;Hormonal;Human;Impaired cognition;improved;Inbred BN Rats;Inflammation;Inflammatory;inflammatory marker;innovation;Interruption;Intervention;Intraperitoneal Injections;Intraventricular Infusion;Investigation;Lactobacillus;late life;Learning;Life;locus ceruleus structure;Medial;Mediating;Memory;Messenger RNA;Methods;Modeling;mutant;Nerve Degeneration;neural circuit;Neuroglia;neuronal excitability;Neurons;noradrenergic;novel;novel therapeutic intervention;older adult;Oral;Osmosis;Pathology;Peptides;Peptidyl-Dipeptidase A;Perforant Pathway;Performance;Peripheral;pre-clinical;Prefrontal Cortex;prevent;Probiotics;Public Health;public health relevance;Quality of life;Rattus;receptor;receptor function;Recombinant Proteins;Regimen;Renin-Angiotensin System;Reporting;Research;Research Design;Rodent;sex;Signal Transduction;Signaling Molecule;Subcutaneous Injections;Synapses;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;Therapeutic;Thinking;Transgenic Organisms;translation to humans;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: ANG1-7 as an intervention for Alzheimer's Disease.


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BATON ROUGE

ORG_DEPT: BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative: Overall Our Center is focused on understanding the environmental and health impacts of biologically active, environmentally persistent free radicals (EPFRs). These pollutant-particle systems, emitted from thermal treatment of Superfund or other hazardous wastes, have been shown to impact respiratory, cardiovascular, and metabolic health. Currently, no rules or regulations for limiting or monitoring EPFRs in the environment exist, and the studies from our Center will guide environmental and public health policy.

PI_NAMEs: CORMIER, STEPHANIA A (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Adult;Advisory Committees;Advocacy;Affect;Age;Archives;Area;Asthma;Atmosphere;Attenuated;Biological;biomarker identification;Birth;Cardiac;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;Chemicals;Chemistry;Child;Childhood;Childhood Asthma;cohort;Communication;Communities;community engagement;Copper;Data;Data Analyses;data management;Degradation Pathway;detection method;Dioxins;Education;Engineering;Ensure;Environment;Environmental Health;environmental particulate;Evaluation;Exclusion;experience;exposed human population;Exposure to;F2-Isoprostanes;Factor Analysis;Failure;Fostering;Free Radical Formation;Free Radicals;Free Will;Functional disorder;Funding;Goals;Government Agencies;ground water;Hazardous Substances;Hazardous Waste;Health;Health Policy;House Dust;Human;Hydroxyl Radical;improved;in vivo;Industry;Inhalation Exposure;Inhalation Toxicology;interdisciplinary approach;iron oxide;Link;Location;Lung;Metabolic;metal oxide;Metals;Methods;Monitor;mouse model;Organic Chemicals;Organism;Outcome;oxidative damage;Oxidative Stress;Oxidative Stress Induction;particle;Particulate Matter;Persons;Physics;Pneumonia;pollutant;Population;prevent;Prevention;Process;programs;Protocols documentation;Public Health;Reaction;Reagent;Regulation;remediation;Research;Research Personnel;Research Project Grants;Resources;respiratory;respiratory health;Risk;Risk Assessment;Role;Route;Sampling;sensor;Services;Silicon Dioxide;Site;success;Superfund;superfund site;Surface;System;technique development;Technology;Toxic effect;Training;Transition Elements;treatment site;wasting;web portal;Wheezing;Work

PROJECT_TITLE: LSU Superfund Research Center - Environmentally Persistent Free Radicals


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a devastating brain disease in aged population that has no cure. Mounting evidence supports that regular exercise has profoundly positive impacts on AD; however, the scientific reasons are poorly understood. We have obtained evidence and generated animal models to unveil the functional role and control of the removal of damaged/unfunctional mitochondria, the powerplants of cells, in the nerve cells in the brain by two types of exercise training (aerobic exercise and weight training) to mitigate AD in mice and lay solid foundation for developing effective therapeutics for AD.

PI_NAMEs: YAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;abeta deposition;Acute;Address;Adult;Aerobic Exercise;Affect;Age Months;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein Precursor;Animal Model;arm;Autophagocytosis;Autopsy;beta amyloid pathology;Biochemical;Biological Assay;Brain;Brain Diseases;Cells;Central Nervous System;cognitive function;Color;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;Disease;DNA;drinking water;endurance exercise;Excision;Exercise;exercise training;familial Alzheimer disease;field study;Foundations;gain of function;Gene Proteins;Genetic;Genetic Models;Hippocampus;hyperphosphorylated tau;Image;Immunofluorescence Immunologic;Impaired cognition;improved;Injury;J20 mouse;Knock-in Mouse;Learning;Lipids;loss of function;Mediating;Memory;Metformin;Mitochondria;Modeling;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;oxidative damage;Oxidative Stress;Pathologic;Pathology;Persons;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Power Plants;prevent;Preventive;progressive neurodegeneration;Protein Kinase;Proteins;Publishing;Radial;Reactive Oxygen Species;Regulation;Reporter;resistance exercise;response;Reticulum;Role;Running;Sampling;sedentary;sensor;Solid;Structure;tau Proteins;tau-1;Testing;Therapeutic;therapeutic target;therapeutically effective;Training;transcriptomics;Water;Weight;Weight Lifting;Western Blotting

PROJECT_TITLE: Exercise-Induced Mitophagy In Hippocampal Neurons Against AD

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative: Administrative Core Environmentally persistent free radicals (EPFRs) are pollutant-particle systems emitted from thermal treatment technologies, or wind-blown dusts created during remediation and containment activities of Superfund wastes. Our research has shown that inhalation exposure to EPFRs elicits cardiac and pulmonary dysfunction. The Administrative Core supports the program’s goals by providing a cohesive administrative structure to manage the diverse aspects of the Center and ensuring that our data improves public health by guiding site remediation, decision-making, and environmental policy.

PROJECT_TERMS: Address;Advisory Committees;Agreement;American Lung Association;Appointment;Archives;Australia;Automobile Driving;Biomedical Research;California;Cardiac;chemical safety;Chemicals;Collaborations;Communication;Communities;community engagement;Consult;Containment;Data;Data Analyses;Data Collection;data communication;data management;Data Storage and Retrieval;Decision Making;design;Development;Devices;Dominican;Dust;Economic Development;Education;Educational workshop;effectiveness evaluation;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Policy;Environmental Science;Evaluation;experience;Exposure to;Faculty;Feedback;flexibility;Fostering;Free Radicals;Functional disorder;Goals;Group Meetings;Group Structure;Hazardous Waste;Health;Health Sciences;Healthcare;high risk;IACUC;improved;Industry;Information Dissemination;Information Management;Infrastructure;Inhalation;Inhalation Exposure;innovation;Institution;Institutional Review Boards;interdisciplinary approach;Interdisciplinary Study;Investments;Laboratories;Leadership;Logic;Louisiana;Lung;Measures;meetings;member;Mission;Modeling;Monitor;National Institute of Environmental Health Sciences;North Carolina;organizational structure;Participant;particle;Performance;Phase;pollutant;programs;Public Health;Queensland;remediation;Reporting;Research;Research Activity;research and development;Research Design;research facility;Research Personnel;Research Support;Resolution;Resources;Schedule;scientific organization;Services;Signal Recognition Particle;Site;Statistical Data Interpretation;Structure;success;Superfund;supportive environment;symposium;synergism;System;Technology;Technology Transfer;Training;translational health science;translational impact;Translational Research;Travel;Universities;Veterinary Medicine;Veterinary Schools;wasting;web portal;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative: Data Management and Analysis Core (DMAC) This Core will implement a comprehensive data management and analysis plan based on proven data capture, distribution, and storage technology, coupled with support from a highly experienced statistical team. Our integrated approach will facilitate collaborations among researchers using the rich datasets generated by SRP investigators and others to answer important questions of environmental and public health significance.

PI_NAMEs: MERCANTE, DONALD E (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Architecture;Archives;Biometry;Cardiovascular system;Code;Collaborations;Communities;Complex;complex data;Computer software;computerized tools;Computers;Coupled;Data;data acquisition;Data Analyses;Data Collection;data management;Data Management Resources;data platform;data quality;data reduction;Data Security;Data Set;data sharing;Data Storage and Retrieval;data visualization;data warehouse;Database Management Systems;design;Development;dimension reduction;Education;Educational workshop;Elements;Ensure;Environment;Environmental Health;experience;Experimental Designs;Experimental Models;Exposure to;Faculty;FAIR principles;Free Radical Formation;Free Radicals;Functional disorder;Funding;Goals;graduate student;Health;Human;Image;improved;Individual;Informatics;innovation;instrument;Interdisciplinary Study;Investigation;investigator training;kinetic model;Knowledge;large datasets;lectures;Lung;machine learning method;Mediation;member;Methodology;Methods;Mission;Modeling;multidimensional data;multidisciplinary;novel;novel strategies;open data;Pathway interactions;Persons;Postdoctoral Fellow;Preparation;prevent;Program Research Project Grants;programs;Protocols documentation;Public Health;Publications;quality assurance;Quality Control;Randomized;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;respiratory health;Sampling;Science;Secure;semiparametric;Services;skills;Source;Speed;Standardization;Statistical Data Interpretation;Statistical Models;success;Superfund;Survival Analysis;System;Technology;Testing;theories;Time;timeline;tool;Training;Work

PROJECT_TITLE: Data Management & Analysis Core (DMAC)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Project Narrative: Community Engagement Core (CEC) The new CEC consists of two major initiatives: the LSU Clean Air Research Engagement for Superfund Communities (LaCARES) and the LSU SRP Environmental Health Literacy Project. LaCARES is a CBPR program wherein residents of two communities where TT of hazardous materials has been conducted share their observations and work with Center researchers to help select locations for new field samplers to detect and assess exposures to EPFRs. The LSU SRP Environmental Health Literacy Project will include bidirectional engagement with Superfund communities where TT may be used as a site-remediation method and an annual break-out meeting during the Dellinger Symposium for community leaders, regulators, industry representatives, and researchers to explore best practices for CBPR and exposure-reducing strategies for EJ communities.

PI_NAMEs: REAMS, MARGARET A (contact)

PROJECT_TERMS: Address;Adoption;African American;Agreement;Air;air monitoring;Antioxidants;Area;Businesses;Cardiovascular system;chemical bond;Collaborations;Communication;Communities;community based participatory research;community based practice;community building;community engagement;community partners;community partnership;Data;design;Diet;Education;Educational workshop;effectiveness evaluation;Environment;Environmental Health;environmental justice;Environmental Pollutants;Exercise;experience;Exposure to;Face;Facility Regulation;Fostering;Free Radical Formation;Free Radicals;Functional disorder;Goals;Government Officials;guidebooks;Hazardous Substances;Hazardous Waste;Health;health literacy;high school;Home;Household;Human;Human Resources;improved;Individual;Industry;Inhalation;innovation;insight;Interactive Communication;Intervention;Knowledge;literacy;Local Government;Location;Louisiana;Low income;Lung;Measurement;Measures;meetings;member;Metabolic;Methodology;Methods;Monitor;neighborhood safety;Nutrient;Odors;operation;oxidative damage;Oxidative Stress;Participant;particle;Particulate Matter;Performance;Persons;physical symptom;pollutant;prevent;Prevention;programs;Published Comment;remediation;Reporting;Research;Research Personnel;resilience;respiratory;Risk;Risk Assessment;Risk Management;Risk Reduction;Running;Sampling;Science;Series;service learning;Signal Recognition Particle;Site;smartphone application;Superfund;superfund site;Surface;symposium;Symptoms;Testing;Text;Toxic effect;Transition Elements;Translational Research;treatment site;Universities;university student;Update;Waste Management;wasting;web site;Work

PROJECT_TITLE: Community Engagement Core (CEC)


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_DEPT: VETERINARY SCIENCES

PI_NAMEs: DUGAS, TAMMY R (contact)

PROJECT_TERMS: Affect;Air Pollution;Area;Cardiovascular system;career development;Chemistry;Collaborations;Communication;Communities;community engagement;Complex;Data;Data Analyses;data management;data sharing;Development;Dioxins;Discipline;Education;Ensure;Environment;Environmental Health;Environmental Science;Ethics;Exercise;experience;Exposure to;externship;Faculty;faculty mentor;Focus Groups;Free Radicals;Functional disorder;Funding;Goals;graduate school;graduate student;Grant;Group Meetings;Growth;Health;High School Student;Historically Black Colleges and Universities;Home;Human;improved;Individual;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;interest;Interview;K-12 student;Leadership;Learning;learning strategy;lectures;Lung;meetings;Mentors;metal oxide;Methodology;Methods;Minority Groups;minority student;minority undergraduate;Oxidation-Reduction;Particulate Matter;Personal Satisfaction;Physics;Play;pollutant;Population Heterogeneity;Postdoctoral Fellow;prevent;programs;Reaction;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Risk;Science;Scientist;service learning;Signal Recognition Particle;skills;Students;success;Superfund;teacher;Techniques;Toxicology;Training;Training Activity;Training Programs;translational engagement;Translational Research;undergraduate student;Universities;Vision;Visit;webinar;Work;Writing

PROJECT_TITLE: Research Experience and Training Coordination Core (RETCC)


ORG_DEPT: CHEMISTRY

PHR: Project Narrative: Materials Core The MC is a support Core whose main purpose is to provide combustion-borne PM that contain EPFRs to the research Projects for the study of their properties and health effects. This is achieved by synthesis of such particles in a laboratory environment and from PM field sample retrieval from media (collected in Project 3), followed by chemical characterization and distribution to Projects 1, 2, 4 and 5 for further study. The MC will also provide analytical expertise to all projects in respect to chemical analysis and thermal decomposition analysis of samples, as needed by the Projects.

PI_NAMEs: KHACHATRYAN, LAVRENT  (contact)

PROJECT_TERMS: Address;advanced analytics;Affect;Airborne Particulate Matter;Benzene;Biological;Biological Models;Biomedical Research;cardiovascular health;Characteristics;chemical property;Chemicals;Chlorinated Hydrocarbons;Collection;combustion product;Communication;Communities;community collaboration;community engagement;Complex;Controlled Environment;Custom;Data;density;design;design and construction;Diagnostic;Dioxins;Environment;Environmental Engineering technology;Environmental Health;Environmental Science;Equipment;Event;experience;Experimental Designs;experimental study;exposed human population;Free Radicals;Funding;Generations;hazard;Hazardous Substances;Hazardous Waste;Health;Health Hazards;improved;Industrialization;instrumentation;Iron;Laboratories;Maintenance;Metals;method development;Methodology;Methods;Modeling;Modification;National Institute of Environmental Health Sciences;particle;Particulate Matter;Phenols;pollutant;Procedures;Process;Production;programs;Property;remediation;repository;Reproducibility;Research;Research Project Grants;research study;respiratory health;Retrieval;Sampling;Services;Soil;Specific qualifier value;Stream;success;Superfund;superfund site;System;Techniques;Technology;Testing;Transition Elements;Translational Research;Translations;treatment site;Wood material;Work

PROJECT_TITLE: Materials Core (MC)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This K99 career development award will support training and research into the neurobiology of restricted and repetitive behaviors (RRB) in children with autism spectrum disorder and examine the effectiveness of N- acetylcysteine, a well-tolerated nutritional supplement and glutamatergic modulator, for targeting the neurobiology of RRB to reduce symptom severity. The primary goal of this training and research program is to help an extremely promising early career research scientist further develop an independent line of research and successfully transition to an independent research position.

PI_NAMEs: HEGARTY, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acetylcysteine;adaptive learning;adult with autism spectrum disorder;Affect;Aftercare;aged;Animals;Anterior;autism spectrum disorder;autism symptoms;autistic children;Award;Behavior;Behavior assessment;Biological;Biological Markers;biomarker discovery;career;career development;Child;Childhood;cingulate cortex;Clinical;clinical investigation;Clinical Trials;Complex;Corpus striatum structure;Cross-Over Studies;Data;Development;dietary supplements;Disease;Dose;Double-Blind Method;effective intervention;effectiveness evaluation;efficacy evaluation;Electroencephalography;Etiology;Evoked Potentials;Exhibits;Fostering;Foundations;Functional disorder;glutamatergic signaling;Glutamates;Goals;Heterogeneity;improved;Individual;interest;Intervention;Intervention Studies;Investigation;K-Series Research Career Programs;Learning;Measures;Mediating;Membrane Potentials;Mentors;Methodology;model of autism spectrum disorder;motor behavior;mouse model;neural;Neurobiology;Neurodevelopmental Disorder;neuroimaging;neuropsychiatric disorder;novel;Obsessive compulsive behavior;Outcome;Pathway interactions;pharmacologic;Pharmacotherapy;Placebos;Population;Positioning Attribute;practical application;precision medicine;Prediction of Response to Therapy;programs;Protons;randomized placebo controlled trial;Randomized, Controlled Trials;recruit;reduce symptoms;repetitive behavior;Reporting;Research;research and development;Research Personnel;response;Role;Scientist;Sensory;Severities;Signal Transduction;skill acquisition;skills;Specificity;Spectrum Analysis;Statistical Models;Subgroup;Symptoms;targeted agent;Techniques;theories;Training;Training Support;Treatment Efficacy;treatment response

PROJECT_TITLE: Targeting the neurobiology of restricted and repetitive behaviors in children with autism using N-acetylcysteine

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Lung

PHR: Project Narrative: Inhalation Toxicology Core (ITC) Major objectives of this Superfund Research Program (SRP) include determining the in vivo and in vitro responses of cardio-pulmonary system components following exposures to real-world, EPFR-containing particles. We have developed a customized Venturi-based aerosolization system to generate EPFR-rich aerosols for both in vivo and in vitro exposures, thus allowing for maximum direct comparability between the two exposure modalities. The ITC will provide the expertise, facilities, and equipment necessary for LSU SRP investigators to expose either mice or cell cultures to aerosolized and well-characterized EPFR-rich aerosols.

PI_NAMEs: NOEL, ALEXANDRA  (contact)

PROJECT_TERMS: aerosolized;Aerosols;Agonist;Air;Airborne Particulate Matter;airway epithelium;Alveolar;Animals;aqueous;Area;Aryl Hydrocarbon Receptor;Biomedical Research;Blood;Breathing;Cardiopulmonary;cardiopulmonary system;Cell Culture Techniques;Cell surface;Cells;Chemicals;Coculture Techniques;Collaborations;Collection;Complement;Complex;Complex Mixtures;Custom;Cytochrome P450;Data;Data Set;Deposition;design;Dose;dosimetry;Dryness;Environment;Environmental Exposure;Environmental Pollutants;Epithelial Cells;Epithelium;Equilibrium;Equipment;experimental study;exposed human population;Exposure to;Free Radicals;Functional disorder;Goals;Health;Helper-Inducer T-Lymphocyte;Immunologics;In Vitro;in vitro Model;in vivo;Inhalation;Inhalation Exposure;Inhalation Toxicology;innovation;insight;instrumentation;Life;Lipids;Liquid substance;Louisiana;Lung;Measurement;Measures;Mediating;Membrane Lipids;Methodology;Methods;Mission;Modality;Modeling;Molecular;Morphology;Mus;novel;oxidation;Oxidative Stress Induction;particle;particle exposure;Particulate;Particulate Matter;Pattern;Physiological;pneumocyte;pollutant;Postdoctoral Fellow;pressure;Production;Program Research Project Grants;programs;Property;pulmonary function;Pulmonary function tests;Quartz;Receptor Activation;Receptor Signaling;remediation;Research;Research Personnel;Research Project Grants;Resistance;respiratory;respiratory health;response;Rodent;Route;Sampling;Superfund;Surface;Suspensions;System;Techniques;Time;Toxic effect;Training;ultrafine particle;Universities;vapor;Work

PROJECT_TITLE: Inhalation Toxicology Core (ITC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE STATEMENT. The at age death, tau form o frontotemporal lobar degeneration (FTLD-tau) is a class of neurodegenerative diseases found autopsy that underlies a wide range of clinical dementia syndromes, commonly affecting individuals under 65. The proposed work aims to clarify the relationship between FTLD-tau, pathologic markers of cell in vivo MRI atrophy patterns, and distinct clinical features of FTLD-related dementia syndromes. f Findings will inform our understanding of the putative substrates of neurodegeneration in FTLD-tau, and are highly relevant to the future development of disease-specific biomarkers and therapeutic approaches.

PI_NAMEs: GEFEN, TAMAR D (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Anatomy;Aphasia;Atrophic;Autopsy;base;Behavior;Behavioral;behavioral variant frontotemporal dementia;Bilateral;Brain;Cell Death;Cells;Cellular Morphology;cerebral atrophy;Cessation of life;Clinical;clinical heterogeneity;clinical phenotype;Cognition;cohort;Complex;Comprehension;corticobasal degeneration;Dementia;Development;Diagnosis;diagnostic tool;Disease;Environment;Failure;Frontotemporal Lobar Degenerations;Functional disorder;Future;Goals;granule cell;Histologic;Human;Image;Impaired cognition;Impairment;in vivo;Individual;Inferior frontal gyrus;International;language impairment;Left;Magnetic Resonance Imaging;Methods;Microglia;Modeling;MRI Scans;multidisciplinary;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;Neuropsychology;Outcome;Pathologic;Pathology;Patients;Pattern;Personality;Phenotype;Pick body;Pick Disease of the Brain;Primary Progressive Aphasia;Progressive Aphasias;Progressive Supranuclear Palsy;public health relevance;Regional Anatomy;regional atrophy;Semantics;specific biomarkers;Specificity;Specimen;Symptoms;Synapses;Syndrome;tau Proteins;Tauopathies;Therapeutic;Tissues;Variant;Work

PROJECT_TITLE: Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Clinical Research;Lung

PHR: Project Narrative: Project 1 This study addresses questions related to the pulmonary and metabolic effects of EPFRs, a recently realized pollutant species found at Superfund sites and formed during thermal treatment processes. As there are currently no rules or regulations for limiting or monitoring EPFRs in the environment, these studies, in the context of the Center, will have important implications for guiding environmental and public health policy.

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Air;airway epithelium;Archives;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Asthma;Biological Markers;biological systems;biophysical techniques;Biophysics;Birth;Carbazoles;Cardiac;Cells;Child;cohort;Collaborations;Complex;Cytochrome P450;Cytochromes b5;cytokine;Data;Data Analyses;data management;Dendritic Cells;Disease;Elements;Environment;Environmental Health;environmental particulate;Enzymes;Epidemiology;Epithelial Cells;Exclusion;Exposure to;Family;Free Radicals;Functional disorder;Funding;Genetic Transcription;glutathione sulfonamide;Government Agencies;ground water;Hazardous Waste;Health;Health Policy;Helper-Inducer T-Lymphocyte;Homeostasis;House Dust;Human;Immune;Immune response;Immunologics;In Vitro;in vivo;Inflammatory Response;Inhalation;Inhalation Toxicology;Kinetics;Laboratories;Life;Ligands;Link;Liquid substance;Lung;Measurement;Mediating;Metabolic;Metabolism;Metals;Monitor;mouse model;Mus;NADPH-Ferrihemoprotein Reductase;National Institute of Environmental Health Sciences;neutrophil;Neutrophilia;Organic Chemicals;Organism;Outcomes Research;Oxidation-Reduction;oxidative damage;Oxidative Stress Induction;Particulate Matter;Persons;Phenotype;pollutant;Process;Production;programs;Protocols documentation;Public Health;pulmonary function;Receptor Activation;receptor function;Receptor Signaling;Regulation;remediation;Research;respiratory;respiratory health;response;Role;Signal Recognition Particle;Silicon Dioxide;Site;Superfund;superfund site;System;Testing;Translating;Tryptophan;Urine;web portal;Work

PROJECT_TITLE: Environmentally Persistent Free Radicals Alter Pulmonary Immunologic Homeostasis


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Physical Activity;Radiation Oncology;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Narrative The proposed research examines how muscles involved in communication and swallowing are affected by radiotherapy and chemoradiation. Experiments will examine how increased muscle activity in the form of tongue exercise or neuromuscular electrical stimulation may mitigate radiotherapy and chemoradiation-induced deficits in the muscular microenvironment. Further, this work will determine how different treatment modalities induce biological changes and improved function in radiated and chemoradiated tongue muscles

PI_NAMEs: RUSSELL, JOHN A (contact)

PROGRAM_OFFICER_NAME: LEE, CECILIA H

PROJECT_TERMS: Address;Affect;analog;Animal Model;Area;Biochemical;Biological;Biological Assay;Biology;Blood capillaries;cancer therapy;Cephalic;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Chronic;Clinical;Clinical Research;Clinical Services;clinically relevant;Communication;Deglutition;density;Development;Etiology;Evidence based treatment;Exercise;exercise program;exercise training;experimental study;Fibrosis;Foundations;Functional disorder;functional improvement;functional outcomes;Guidelines;Head and Neck Cancer;head and neck cancer patient;Head and Neck Muscle;Head and neck structure;Heterogeneity;Human;Impairment;improved;innovation;Institute of Medicine (U.S.);Knowledge;Legal patent;Linear Regressions;Malignant Neoplasms;Mastication;Measures;Methods;Modality;Modeling;Morbidity - disease rate;Morphology;Movement;Muscle;Muscle Contraction;Muscle Fibers;Muscle function;Muscle satellite cell;Muscle Weakness;muscular structure;muscular system;Myosin Heavy Chains;Neuromuscular Junction;neuromuscular stimulation;Normal tissue morphology;Operative Surgical Procedures;optimal treatments;Organ;Patients;Phenotype;Physiological;Population;prevent;Probability;Proliferating;Property;Quality of life;Radiation;radiation effect;Radiation induced damage;Radiation therapy;Rattus;remediation;Research;Research Design;response;Sampling;Series;service delivery;Skeletal Muscle;Speech;Structure;Testing;Therapeutic Intervention;Time;Tissues;Tongue;translational study;Translations;treatment effect;Treatment Effectiveness;treatment optimization;tumor;Vascular System;Voice;Work

PROJECT_TITLE: Treatment of Functional Deficits IN tongue muscles induced by radiation and chemoradiation treatment

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


PHR: Project Narrative: Project 2 Our project will examine the mechanisms underlying the cardiovascular responses and toxicities produced by inhalation of environmentally persistent free radicals (EPFRs), a unique type of pollutant found at Superfund sites and produced by thermal treatment of those sites. Our studies will provide important new data linking exposure to EPFRs with the development and progression of cardiovascular disease. This information is critical for assessing risks to those living in proximity to sites using thermal treatment technologies to remediate Superfund or other hazardous wastes.

PROJECT_TERMS: Address;Agonist;Air;air filter;Airborne Particulate Matter;Alveolar;alveolar epithelium;Archives;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Binding;Biological Markers;biological systems;Blood;Blood Pressure;Blood Vessels;Body System;Cardiac;Cardiopulmonary;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Catheters;Collaborations;Communities;Data;Data Analyses;data management;design;Development;Devices;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;environmental chemistry;epidemiologic data;Epithelial Cells;Epithelium;Exposure to;free radical oxygen;Free Radicals;Functional disorder;Hazardous Waste;Health;Heart;Heart Diseases;heart function;Histology;Industrialization;Inhalation;Inhalation Exposure;Inhalation Toxicology;Injury;Knowledge;Left;Left Ventricular Function;Ligands;Link;Lipids;Lung;lung pressure;Mass Spectrum Analysis;Measures;Mediating;Mediator;Membrane;Membrane Lipids;Modeling;Morphology;mortality;Mus;Myocardial dysfunction;novel;oxidation;Oxidation-Reduction;Oxidative Stress;oxidized lipid;particle;Particulate Matter;Physiologic intraventricular pressure;Physiological;Play;pollutant;pressure;pulmonary arterial pressure;Pulmonary Vascular Resistance;Reactive Oxygen Species;Receptor Activation;remediation;Research;response;Risk;Risk Assessment;Rodent;Role;Secondary to;Signal Recognition Particle;Site;small molecule;Soil;Source;Superfund;superfund site;System;Technology;Telemetry;Testing;Tissues;Toxic effect;uptake;Vascular Diseases;vascular injury;Ventricular;web portal;Work

PROJECT_TITLE: Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Nanotechnology;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Large craniofacial defects missing a multitude of tissue types from birth, trauma or cancer resection often require complex reconstruction using free tissue transfer, a procedure with high donor site morbidity. Highly translational research would focus on the transfer of engineered, pluripotent stem cells that could induce multi-tissue regeneration in a three dimensional manner. The project characterized herein, which proposes to utilize human adult-derived urine stem cells induced by BMP9 and Notch signaling pathway and novel 3D-printed, citric- acid/graphene scaffolds, has relevance to patients with congenital and acquired complex defects of the craniofacial skeleton.

PI_NAMEs: REID, RUSSELL R. (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adenoviruses;Adult;Anatomy;Architecture;Autologous;battlefield injury;Biocompatible Materials;Biological;Biomechanics;Biomedical Engineering;Birth;bone;bone morphogenetic protein 9;Bone Morphogenetic Proteins;Bone structure;Bone Tissue;Calvaria;cancer surgery;Cell Line;Cells;cellular transduction;Cephalic;Chicago;Child;Citrates;Citric Acid;clinical application;Collaborations;Complex;Craniofacial Abnormalities;craniofacial structure;craniofacial tissue;cranium;Cues;Data;Defect;design;Engineering;Engraftment;Excision;Experimental Designs;Face;Failure;functional outcomes;Goals;graphene;Growth;healing;Human;human stem cells;human subject;Hybrids;Hydrogels;implantation;In Vitro;in vivo;Individual;infection risk;Injury;Malignant Neoplasms;manufacturing technology;Mesenchymal Stem Cells;Methods;microCT;Modality;Modeling;Morbidity - disease rate;Mus;Natural regeneration;notch protein;Notch Signaling Pathway;novel;novel strategies;Operative Surgical Procedures;Osteogenesis;osteogenic;Pathway interactions;Patients;Phase;Pluripotent Stem Cells;Porosity;Printing;Procedures;progenitor;programs;prototype;Rattus;reconstruction;regenerative;repaired;Reproducibility;Research;restoration;Risk;Rodent Model;scaffold;Scalp structure;Shapes;Signal Transduction;Site;skeletal;Skeleton;Skin;skin healing;soft tissue;Solid;Source;spatiotemporal;Specimen;stem cell differentiation;stem cells;Structure;success;Surface;Surgeon;synergism;Technology;Testing;Time;Tissue Banks;Tissue Differentiation;tissue regeneration;tissue stem cells;Tissues;translational impact;Translational Research;Trauma;treatment strategy;Universities;Urine;Work;X-Ray Computed Tomography;Zygomatic bone

PROJECT_TITLE: Multi-Tissue Craniofacial Engineering using 3D-BMP9-Notch-Synergized Graphene Citrate Composite Scaffolds

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative: Project 3! This study addresses questions related to human exposure to EPFRs, a recently realized class of pollutant species found at Superfund sites and formed during certain TT processes. Specifically, this research will provide critical information about the extent and duration of air (i.e., EPFR, PM, etc.) and detonation-related noise pollution in communities near Superfund and other TT sites handling hazardous wastes. This comprehensive picture of exposure will have important implications for guiding environmental and public health policy.

PI_NAMEs: RICHMOND-BRYANT, JENNIFER  (contact)

PROJECT_TERMS: Address;Advocacy;African American;Air;Air Pollutants;Archives;atmospheric chemistry;Biological;biological systems;Characteristics;Chemicals;Collaborations;Communities;community based participatory research;community empowerment;community engagement;community organizations;Data;Data Analyses;data management;Databases;Deposition;Dermal;design;Development;economic disparity;empowerment;Ensure;Environment;Environmental Health;environmental justice;Environmental Wind;experience;exposed human population;Exposure to;field study;Fostering;Free Radicals;hazard;Hazardous Waste;Health;Health Policy;Heavy Metals;Home;House Dust;Household;Human;Income;Individual;Infiltration;Infrastructure;Ingestion;Inhalation;Inhalation Toxicology;innovation;insight;Institution;Investments;Measurable;Measures;member;Metals;Military Personnel;Modeling;Monitor;Neighborhoods;Noise;noise exposure;noise pollution;novel;novel strategies;operation;Organic Chemicals;Organism;Participant;Particulate Matter;Perchlorates;Personal Behavior;Persons;pollutant;Population;Probability;Process;programs;Public Health;Public Participation;racial disparity;Recovery;remediation;Research;Resources;Respiratory System;sample collection;Sampling;sensor;Silicon Dioxide;Site;Smoke;Source;Speed;Strategic Planning;stressor;Superfund;superfund site;Surveys;Testing;Time;Transition Elements;Translational Research;Translations;treatment site;ventilation;waste treatment;wasting;web portal;Work

PROJECT_TITLE: Hazardous Waste Thermal Treatment and Community Exposure to Environmentally Persistent Free Radicals