NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because it focuses on developing clinically validated predictive markers for response in chronic lymphocytic leukemia (CLL), which will result in personalized therapies for people with CLL and prospectively identify high-risk patients. These data will identify therapeutic vulnerabilities leading to novel therapeutic approaches that improve patient outcomes. Thus, the proposed research is relevant to the part of the NCI’s mission that pertains to advancing scientific knowledge and helping people live longer, healthier lives.

PI_NAMEs: SOUMERAI, JACOB  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: 17p;Abbreviations;Achievement;Address;Aftercare;Anemia;Antibodies;assay development;BCL2 gene;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biometry;Bone Marrow;Cancer Personalized Profiling by Deep Sequencing;career;career development;Chronic Lymphocytic Leukemia;Clinical;Clinical Research;clinical translation;Clinical Trials;Clonal Evolution;Data;Detection;detection limit;Development;Development Plans;Disease remission;Doctor of Philosophy;Ensure;Evaluation;experience;Failure;Fellowship;Funding;General Hospitals;genomic predictors;genomic signature;Globulins;Goals;Health;Hematologist;high risk;improved;improved outcome;inhibitor;inhibitor therapy;Kinetics;Knowledge;Lactate Dehydrogenase;leukemia treatment;Lymphoma;Massachusetts;Medical Oncologist;medical schools;Medicine;Mentors;Mentorship;Mission;MS4A1 gene;Mutation;novel therapeutic intervention;Patient Care;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Persons;Phase;phase II trial;Positioning Attribute;predictive marker;predictive signature;Procedures;professor;prognostic model;programs;prospective;Public Health;Recurrent disease;Relapse;relapse patients;Research;Research Personnel;Residual Neoplasm;Resistance;resistance mechanism;response biomarker;Retreatment;Risk;Risk Factors;Sampling;Scientific Advances and Accomplishments;skills;success;targeted sequencing;Technical Expertise;Techniques;Testing;Therapeutic;therapy duration;Time;TP53 gene;Training;Training Activity;Translations;treatment duration;Treatment Efficacy;tumor DNA;Variant

PROJECT_TITLE: Predictive markers for personalized therapy in chronic lymphocytic leukemia


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Quantitative measures of hormone levels are critical to the diagnosis, management, and treatment of endocrine disorders, and are central to fertility planning and assisted reproductive technologies. We proposed to develop a novel class of inexpensive, real-time, sensors based on the discovery and functionalization of microbial hormone sensing proteins. We will demonstrate the utility of our novel sensors by developing a point- of-care microfluidic device for real-time hormone measurements from urine.

PI_NAMEs: GALAGAN, JAMES E (contact);KLAPPERICH, CATHERINE M.

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Affect;Agriculture;Antibodies;Assisted Reproductive Technology;Bacteria;Biochemical;Biological Assay;Biology;Biosensor;Biotechnology;Cells;Characteristics;Clinical;Complement;Compost;cost;Data;design;Development;Devices;Diagnosis;Directed Molecular Evolution;drug development;Electronics;Endocrine System Diseases;Engineering;Environmental sludge;Estrogens;experimental study;fabrication;Fertility;Fluorescence Resonance Energy Transfer;Food;Genomics;Health;Healthcare;Hormone imbalance;Hormones;Human Microbiome;improved;In Vitro;Infertility;Intercellular Fluid;Measurement;Measures;microbial;Microfluidic Microchips;Mining;Modeling;Monitor;novel;novel strategies;optical sensor;Optics;Performance;point of care;Population;portability;portable monitoring;Postmenopause;Premenopause;Progesterone;Proteins;Quantum Dots;Reaction Time;Reader;Reproducibility;Safety;Sampling;screening;Seawater;sensor;Soil;Source;steroid hormone;Steroids;Sterols;Stimulus;success;Technology;Testing;Time;transcription factor;Urine;virtual;Water;Woman;Work

PROJECT_TITLE: Novel Biosensors based on Mining Bacterial Transcription Factors

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vector-Borne Diseases

ORG_CITY: FREDERICK

ORG_NAME: MEDIGEN, INC.

ORG_STATE: MD

PHR: NARRATIVE Venezuelan equine encephalitis virus (VEEV) is an emerging, biodefense-relevant pathogen that causes severe morbidity and mortality in humans and animals. There is no approved human VEEV vaccine. Development of VEEV vaccine is in line with the mission of the NIH as outlined in the 2007 NIAID Strategic Plan for Biodefense Research. Live-attenuated vaccines provide successful vaccination with a single dose, which is required for rapid outbreak containment. In this Phase 1 clinical trial proposal we investigate safety and immunogenicity of rationally designed, novel live-attenuated vaccine V4020 with rearranged genome for increased safety.

PI_NAMEs: PUSHKO, PETER M. (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Adjuvant;Adult;Adverse effects;Age Years;Alpha Virus;Animals;Attenuated;Attenuated Vaccines;attenuation;biodefense;Bioterrorism;bioweapon;Capsid;Categories;Central America;Chikungunya virus;Clinical;Clinical Research;Clinical Trials Design;CMV promoter;Collaborations;Combined Vaccines;Communicable Diseases;Communication;Complementary DNA;Controlled Clinical Trials;Cyclic GMP;cytokine;Data;design;Development;Disease Outbreaks;DNA;DNA Sequence Rearrangement;DNA Vaccines;Dose;Double-Blind Method;Engineering;Epidemic;epizootic;Equilibrium;Evaluation;experience;first-in-human;Flavivirus;FluMist;Gene Rearrangement;Genes;Genetic;Genetic Transcription;Genome;genomic RNA;Genotype;Glycoproteins;Health Personnel;Human;human pathogen;Human Resources;human study;human subject;Immune response;Immunity;immunogenicity;Immunologics;improved;In Vitro;Inbred BALB C Mice;Individual;infection risk;innovation;insight;Investigational Drugs;Laboratories;Lead;Legal patent;Length;Licensing;Life;Macaca fascicularis;manufacture;Medical;Medical Research;Mission;Modeling;Morbidity - disease rate;mortality;Mus;Mutagenesis;Mutation;National Institute of Allergy and Infectious Disease;neutralizing antibody;nonhuman primate;novel;outbreak control;pathogen;Pathogenicity;Persons;Phase;Phase I Clinical Trials;Phase Ia Clinical Trial;Phenotype;Placebo Control;Placebos;Plasma;Plasmids;Population;Preparation;prevent;primary endpoint;Process;Randomized;rational design;Regimen;Research;research clinical testing;Research Institute;Research Personnel;Research Support;Resistance;Risk;RNA;RNA Viruses;Safety;safety assessment;Saliva;Sampling;Silent Mutation;Strategic Planning;Structural Genes;subcutaneous;Subunit Vaccines;T cell response;Technology;technology platform;Texas;United States;United States National Institutes of Health;Universities;Urine;Vaccination;vaccination protocol;vaccine development;Vaccine Production;vaccine safety;Vaccinee;Vaccines;Variant;vector vaccine;Venezuelan Equine Encephalitis Virus;Venezuelan Equine Encephalomyelitis;Vero Cells;Virus;Virus Diseases;Virus Shedding;volunteer;Volunteer Group;Western Equine Encephalitis Virus;Yellow Fever

PROJECT_TITLE: Safety and Immunogenicity of novel, live-attenuated V4020 vaccine for Venezuelan Equine Encephalitis (VEE) in healthy adults


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endocrine Disruptors;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Whereas evidence is accumulating that exposure of pregnant women to toxic substances may initiate hereditary diseases that run in the family with or without involving DNA mutations, our knowledge about how various types of toxicants can introduce persistent damages into the genetic materials of human germ cell precursors responsible for production of sperm or eggs has been limited due to the lack of convenient experimental model of such precursor cells. Taking advantage of our recent accomplishment that enables perpetual expansion of human germ cell precursors in the laboratory as cell culture, we propose a research project aiming at examining persistent damages in the genetic materials of germ cell precursors caused by exposures to toxic chemicals. Outcomes of our research will immediately teach not only academic research laboratories but also the hospital clinicians, the industry, or the governmental agencies regulating chemical safety about the risk and mechanisms of heritable damages caused by exposure to environmental chemicals or therapeutic drugs, including chemotherapy agents.

PI_NAMEs: SHIODA, TOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Adult;Affect;Apoptosis;Apoptotic;BAK1 gene;base;BAX gene;Benzo(a)pyrene;Biological Assay;bisphenol A;bisulfite sequencing;Cell Culture Techniques;Cell Death Induction;Cell Separation;cell type;Cells;Characteristics;Chemical Actions;Chemical Exposure;chemical safety;Chemicals;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Child;ChIP-seq;cigarette smoke;Cisplatin;Clinical;Communities;Cultured Cells;Cyclophosphamide;Disease;DNA;DNA Damage;DNA Repair;DNA Sequence Alteration;Educational process of instructing;egg;Embryo;Endocrine Disruptors;environmental chemical;Environmental Risk Factor;Epigenetic Process;Evaluation;Experimental Models;exposed human population;Exposure to;Familial disease;Family;Female;Fertility;Future;Generations;Genetic;Genetic Engineering;Genetic Materials;Genome;genome-wide;Genomic DNA;Genomics;genotoxicity;Germ Cells;Germ Lines;Health;Hereditary Disease;Heritability;high risk population;Histones;homologous recombination;Hospitals;Human;Human body;human induced pluripotent stem cells;human model;Impaired health;Impairment;In Vitro;in vitro Model;Industry;insight;Intervention;Knock-out;Knowledge;Laboratories;Laboratory Research;Lesion;Location;male;Methods;Methylation;Modeling;Mus;Mutagens;Mutate;Mutation;nanoparticle;next generation;Nonhomologous DNA End Joining;novel;Nucleotides;offspring;Organ Culture Techniques;Outcome;oxidation;Paint;Pattern;perfluorooctane sulfonate;perfluorooctanoic acid;Pharmaceutical Preparations;phthalates;Pluripotent Stem Cells;Poison;Poly-fluoroalkyl substances;Population;precursor cell;Pregnant Women;Prevalence;prevent;Production;programs;Proteins;Purines;Pyrimidine;reconstitution;Research;Research Project Grants;Resistance;Risk;Risk Assessment;Running;screening;Seminiferous tubule structure;senescence;Serum;Somatic Cell;Specimen;sperm cell;Stains;Stress;Structure;Structure of primordial sex cell;substance use;System;Techniques;Testing;Testis;Therapeutic;titanium dioxide;Toxic Environmental Substances;toxicant;Toxicology;trait;transcriptome sequencing;tributyltin;Variant;whole genome

PROJECT_TITLE: Applications of the long-term culture human primordial germ cell-like cells to toxicological assessments and mechanistic studies on chemically caused heritable human health threats

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative RNAs play essential roles in nearly every aspect of HIV-1 replication, yet currently available therapeutics only target the proteins of the virus. The Center for Structural Biology of HIV-1 RNA (CRNA) brings together an interdisciplinary team of biomedical specialists to tackle technical challenges and discover structural, dynamic, and biologic properties of HIV-1 RNAs to guide new therapeutic approaches to HIV-1 disease prevention, treatment, and cure.

PI_NAMEs: TELESNITSKY, ALICE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Area;base;Biological;Biological Process;Biology;biophysical techniques;Cells;Chemistry;clinically relevant;comparative;Complex;Cryoelectron Microscopy;Crystallization;Crystallography;Development;Disease;disorder prevention;drug discovery;Electron Microscopy;Elements;Environment;Face;Gene Expression;Genetic Transcription;genomic RNA;Goals;HIV;HIV-1;Host Defense;Image;Immune response;Immunologist;Infection;innovation;Integration Host Factors;light microscopy;Maintenance;member;Microscopy;Molecular;multidisciplinary;next generation;novel therapeutic intervention;Optics;particle;Play;Preparation;Prevention;Prevention approach;Process;Property;protein complex;protein function;protein purification;Proteins;Proviruses;reactivation from latency;Research Personnel;Resolution;RNA;RNA chemical synthesis;RNA metabolism;RNA Splicing;RNA-Protein Interaction;RNA-targeting therapy;Role;Sampling;Science;Services;Specialist;Structural Biologist;structural biology;Structure;Technology;technology development;technology validation;Therapeutic;therapeutic target;Therapeutic Uses;trafficking;Training;Translations;Viral;Viral Proteins;Virion;Virus Replication

PROJECT_TITLE: Center for Structural Biology of HIV RNA


NIH_SPENDING_CATS: HIV/AIDS

PROJECT_TERMS: Collaborations;Communities;Consultations;data sharing;Environment;experience;Goals;HIV;Human Resources;Logistics;Michigan;Occupational activity of managing finances;Output;outreach;Reporting;Research Personnel;RNA;Science;Structural Biologist;structural biology;Universities


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will inform policy decisions regarding therapeutic service delivery in childhood apraxia of speech (CAS). Studying the effectiveness of a motor-based treatment approach, Dynamic Temporal and Tactile Cuing, on speech production and speech motor control in CAS will advance the field and offer significant long-term benefits for children by providing a strong evidence base for further development of DTTC and future clinical trials. This project is relevant to the part of the NI H's mission that pertains to the application of knowledge to enhance health.

PI_NAMEs: GRIGOS, MARIA IRENE (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Aftercare;aged;Articulation;Articulators;Behavior;Child;clinical practice;Clinical Trials;Communication;Complex;Control Groups;Data;Decision Making;design;Development;Developmental apraxia;digital;Effectiveness;efficacy study;efficacy testing;evidence base;evidence based guidelines;Foundations;Future;Gestures;Goals;improved;Individual;individual variation;innovation;Intervention;jaw movement;kinematics;Lip structure;Literature;Maintenance;Measures;Methods;Motion;Motor;motor control;motor deficit;motor disorder;motor learning;Movement;multimodality;Outcome;Outcome Measure;Participant;Pattern;Phase;phase 1 study;phase 3 study;phonology;Policies;Population;Prediction of Response to Therapy;Predictive Factor;Prevalence;primary outcome;Production;public health relevance;Randomized, Controlled Trials;Research;research based treatment;response;Sampling;secondary outcome;service delivery;skills;Speech;Speech Delay;Speech Intelligibility;Tactile;Testing;Therapeutic;treatment duration;treatment guidelines;treatment research;treatment response;trial design;Underserved Population;Work

PROJECT_TITLE: A randomized control trial of motor-based intervention for childhood apraxia of speech

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


PROJECT_TERMS: Advanced Technology Center;Biomedical Research;career;Collaborations;Communities;Development;Development Plans;Education;Educational Activities;Educational workshop;Enrollment;Environment;experience;Feedback;Fostering;Funding;HIV;Interdisciplinary Study;laboratory experience;member;Mentors;next generation;outreach;Postdoctoral Fellow;Research;Research Personnel;RNA;Scientist;Sister;structural biology;Students;Training;undergraduate student;Universities


NIH_SPENDING_CATS: Bioengineering;Genetics;HIV/AIDS

PROJECT_TERMS: Budgets;Cell Physiology;Chemicals;Collaborations;Complex;Computational Technique;computerized tools;Data;data acquisition;Data Analyses;Deposition;design;Development;dimer;Elements;Future;Genetic Transcription;Goals;HIV;HIV-1;Human Resources;innovation;Institution;interest;Isotope Labeling;Label;Letters;Location;member;Methods;Modeling;Nuclear Export;Nucleic Acids;Nucleotides;particle;Positioning Attribute;Preparation;Property;protein data bank;Proteins;Research;Research Personnel;Research Project Grants;Resolution;Response Elements;restraint;RNA;RNA Probes;RNA Splicing;Role;Sampling;Scientist;screening services;Services;Signal Transduction;simulation;Source;structural biology;Structure;System;Techniques;Technology;technology development;tool;Translations;Viral;Virus Replication


PROJECT_TERMS: biophysical properties;Biophysics;Budgets;Cell Line;Collaborations;Complex;Cryoelectron Microscopy;Crystallization;Crystallography;design;design and construction;Development;Development Plans;Electron Microscopy;HIV;Human Resources;improved;In Vitro;Lead;Location;macromolecule;member;Methods;Michigan;Mission;Molecular Biology;Molecular Chaperones;National Institute of Diabetes and Digestive and Kidney Diseases;Phase;Plasmids;predictive tools;Production;protein complex;protein purification;Proteins;Protocols documentation;repository;Research Personnel;Resolution;RNA;RNA chemical synthesis;RNA purification;Role;Scientist;Services;structural biology;Structure;Techniques;technology development;Testing;United States National Institutes of Health;Universities;X-Ray Crystallography


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Tamoxifen has been an effective treatment for estrogen receptor positive breast cancer for several decades. Unfortunately, tamoxifen acts in an opposite manner in the uterus and increases the risk of endometrial cancer. The goal of this project is to determine why tamoxifen promotes endometrial cell growth with the hope of discovering fundamental differences between breast cancer and endometrial cancer and identifying potential treatment targets for endometrial cancer.

PI_NAMEs: GERTZ, JASON  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Accounting;Agonist;antagonist;Antineoplastic Agents;Binding;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;Cancer Patient;cancer risk;cancer type;cell growth;Cells;Cessation of life;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;Collection;CRISPR/Cas technology;Data;Disease;drug development;effective therapy;Endometrial;Endometrial Carcinoma;Endometrium;ESR1 gene;Estradiol;Estrogen receptor positive;Estrogens;Evaluation;experimental study;gene discovery;Generations;Genes;genetic approach;Genetic Transcription;genome editing;genome-wide;Genomic approach;Genomics;Goals;Growth;growth promoting activity;high risk;Hormonal;improved;Incidence;Individual;innovation;insight;Invaded;knock-down;Knowledge;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Methods;migration;Molecular;Molecular Mechanisms of Action;mortality;new therapeutic target;next generation;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Output;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phenotype;Play;Proliferating;Proteomics;Recommendation;Recurrence;Risk;Risk Factors;Risk Reduction;Role;Sampling;Selective Estrogen Receptor Modulators;Seminal;side effect;Survival Rate;Tamoxifen;Techniques;Technology;Testing;therapeutic target;treatment strategy;tumor;tumor progression;Uterus;Woman

PROJECT_TITLE: Mechanisms of tamoxifen-associated endometrial cancer risk


PROJECT_TERMS: Biochemical;Cells;Cellular biology;Collaborations;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Development;Education;Electron Microscopy;experience;experimental study;Goals;high resolution imaging;HIV;HIV-1;Image;imaging approach;improved;In Vitro;innovation;Lead;light microscopy;Methods;Michigan;Mission;particle;programs;protein complex;Proteins;Protocols documentation;repository;Research Personnel;Resolution;Resources;RNA;Running;Sampling;Scientist;structural biology;Structure;Techniques;three dimensional structure;tool;Training;ultra high resolution;Universities;Virus;Wisconsin;Work


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS

PROJECT_TERMS: Area;Biological;Biological Assay;Biological Process;Biology;biophysical analysis;Biophysics;Cells;Cellular biology;chemical synthesis;Chemicals;cheminformatics;Chemistry;Clustered Regularly Interspaced Short Palindromic Repeats;Data;HIV;HIV-1;in silico;In Vitro;inhibitor;Lead;Machine Learning;Molecular Biology;next generation sequencing;novel;protein complex;Proteins;Research Personnel;RNA;screening;Screening procedure;Small Interfering RNA;small molecule;small molecule inhibitor;structural biology;Structure;Techniques;Validation;virology


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: Applied Genetics;Behavior;Biochemical;biophysical properties;Budgets;Capsid;Cells;Chemistry;cofactor;Complex;Cone;Cryoelectron Microscopy;Crystallography;Development;dimer;Dimerization;Engineering;Enzymes;Event;Fullerenes;gag Gene Products;Genes;Genetic Transcription;genomic RNA;Goals;HIV;HIV-1;Human Resources;Image;In Vitro;inhibitor;Integration Host Factors;Lead;Learning;Length;Location;Mediating;Messenger RNA;Molecular;monomer;Morphogenesis;novel;particle;Pathway interactions;pol Gene Products;Poly A;posttranscriptional;Process;protein complex;Provirus Integration;recruit;Research Personnel;Reverse Transcription;Ribonucleoproteins;RNA;RNA Polymerase II;RNA Splicing;Role;scaffold;segregation;small molecule inhibitor;structural biology;Structure;Techniques;Testing;tool;trafficking;Transcript;Transcription Initiation Site;Transfer RNA;Translations;Viral;Viral Physiology;Virion;Virus;Visualization


PROJECT_TERMS: Adopted;Affect;base;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biology;Cell Differentiation process;Cells;cofactor;Collaborations;Complex;CpG dinucleotide;Crystallography;Cytoplasm;Deamination;Epitopes;epitranscriptomics;experimental study;gene product;Genes;Goals;HIV;HIV Genome;HIV-1;Infection;Interferons;Investigation;Lead;Length;Location;Messenger RNA;Modification;novel;Nucleotides;Participant;particle;protein complex;protein function;Proteins;Reader;recruit;Regulation;Research Personnel;RNA;RNA Binding;RNA Recognition Motif;RNA Sequences;RNA Stability;RNA-Protein Interaction;Role;screening;sensor;Specific qualifier value;Specificity;structural biology;Structure;Tertiary Protein Structure;TRIM Gene;TRIM25 gene;TRIM5 gene;Untranslated RNA;Viral;Viral Genome;Viral Physiology;Viral Proteins;viral RNA;Virus;Virus Replication;Zinc Fingers


PROJECT_TERMS: 5' Untranslated Regions;Alternative Splicing;Binding;Binding Proteins;Biological;Budgets;Cell Nucleus;Cells;cis acting element;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;design;Dimerization;DNA Polymerase II;Elements;Event;experience;Gene Expression;Gene Silencing;Genetic;Genetic Transcription;Growth;Guide RNA;HIV;HIV-1;Human Resources;Integration Host Factors;interest;Intervention;Investigation;Knock-out;Laboratories;Lead;Libraries;Life Cycle Stages;Location;Lytic;Maintenance;Mediating;member;Messenger RNA;Methods;Modeling;Modification;Monitor;mRNA Export;Mutagenesis;novel;Nuclear Export;Nuclear Pore;Phase;Play;Polymerase;Positive Transcriptional Elongation Factor B;Process;protein complex;Protein Precursors;Proteins;Proteome;Proviruses;Regulation;Regulatory Element;Research Personnel;Ribosomal Frameshifting;RNA;RNA Binding;RNA chemical synthesis;RNA Polymerase II;RNA Precursors;RNA Probes;RNA Splicing;Role;screening;Site;skills;small molecule;structural biology;Structure;T memory cell;T-Lymphocyte;tat Protein;Technology;Time;tool;trafficking;Transcript;Transcription Elongation;Transcriptional Regulation;Translations;Viral;viral DNA;Viral Genes;viral RNA;Virus;Virus Inhibitors;Virus Replication;Work


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Lymphatic Research;Nanotechnology;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PEABODY

ORG_NAME: PRIVO TECHNOLOGIES, LLC

PHR: Project Narrative  Privo’s Nanotechnology-Engineered Hydrogel, PRV211 is applied as an intraoperative therapy for oral  cancer patients. Following tumor resection, PRV211 is applied directly within the tumor bed to kill  remaining cancerous cells and prevent micrometastasis or recurrence. PRV211’s safety and efficacy has  been proven through multiple sets of animal studies. The team is strongly motivated to pursue effective  prevention of tumor recurrence, with negligible side effects, and planning for a clinical study to evaluate  the impact of PRV211 on the recurrence rate and overall survival in OSCC patients. This treatment has the  potential for improving the progression free survival rates with a great impact on patients’ lives.

PI_NAMEs: GOLDBERG, MANIJEH N (contact);KEITH, DONNA

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Address;aggressive therapy;American;Animals;Appearance;Area;Awareness;Beds;Biological Assay;Biometry;Blood;Budgets;cancer cell;Cancer Patient;cancer risk;Cancerous;Case Report Form;Cells;Cervical;chemotherapeutic agent;chemotherapy;Cisplatin;Clinical;Clinical Research;clinical trial analysis;Clinical Trials;Communities;Contracts;conventional therapy;cost;Country;Coupled;Data;Data Analyses;data management;design;Developed Countries;Disease;Disease remission;disorder control;Documentation;Dose;Dose Limiting;draining lymph node;Drug Kinetics;electronic data;electronic data capture system;Electronics;Eligibility Determination;Engineering;Enrollment;Ensure;Excision;Exercise;experience;follow-up;Foundations;Funding;Head;Head and Neck Cancer;Hour;Humidity;Hydrogels;Immune checkpoint inhibitor;immunoregulation;Immunotherapy;improved;Incidence;Income;Infrastructure;Institutional Review Boards;Intravenous;Life;Life Style;lymph nodes;malignant mouth neoplasm;Malignant Neoplasms;manufacture;mass spectrometer;Mediation;Medical;Metastatic Neoplasm to Lymph Nodes;Methods;microbial;Micrometastasis;Modality;Monitor;mouth squamous cell carcinoma;nanoengineering;nanoparticle;Nanotechnology;Nodal;novel;operation;Operative Surgical Procedures;oral care;oral HPV;outreach;Outsourcing;oxidation;Patient Participation;patient population;Patient Recruitments;Patients;Pharmaceutical Preparations;Phase;phase 2 study;photolysis;Plasma;Platinum;Prevalence;prevent;Prevention;Privatization;Procedures;Production;Prognostic Factor;Progression-Free Survivals;Protocols documentation;Quality Control;Radiation;Records;Recurrence;Recurrent tumor;Regimen;Research Personnel;Resource-limited setting;Resources;response;Risk Factors;RTN4 gene;Safety;Sampling;side effect;Site;socioeconomics;Solid Neoplasm;Source;Squamous cell carcinoma;stability testing;Statistical Data Interpretation;Sterilization;Stress;Stress Tests;Survival Rate;targeted agent;Temperature;therapeutic nanoparticles;timeline;tool;Toxic effect;Treatment Failure;Treatment Protocols;Treatment-related toxicity;tumor;Tumor Debulking;Tyrosine Kinase Inhibitor;United States;Viscosity;Visit;Whole Blood

PROJECT_TITLE: Clinical Studies for Improving Survival Rates for Oral Cancer Patients in Low Resource Settings


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Rhabdomyosarcoma (RMS) is the most common childhood sarcoma, yet little is known about how chromatin regulators control tumor-propagating cells and tumor relapse after treatment. Here, we will dissect the role of polycomb complex 2 and its catalytic subunit EZH2 in regulating RMS cell state transitions by employing single-cell multiomics sequencing, functional assays, and novel preclinical zebrafish and mouse models. This study will broaden our understanding of how chromatin regulators control tumor cell state transitions and will contribute to developing novel therapies for rhabdomyosarcoma patients.

PI_NAMEs: WEI, YUN  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Affect;Aftercare;Animal Model;Bar Codes;Binding;Biological Assay;cancer cell;Catalytic Domain;Cell Cycle;Cell Differentiation process;cell killing;Cell Line;Cell Lineage;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;childhood sarcoma;Childhood Soft Tissue Sarcoma;Chromatin;Clinic;Collaborations;Complex;cost;Cyclophosphamide;Dactinomycin;deep sequencing;drug testing;dynamical evolution;Epigenetic Process;Evolution;EZH2 gene;Frequencies;Gene Expression;gene repression;Genetic Transcription;Goals;Heterogeneity;Histone H3;histone methylation;Histones;Image;Immune;Impairment;improved;in vivo;inhibitor;innovation;Inter-tumoral heterogeneity;irradiation;knock-down;Knowledge;Lysine;Malignant Neoplasms;Mesenchymal;Messenger RNA;Methylation;Modeling;Modification;Molecular;mouse model;multiple omics;Mus;Muscle;Muscle Cells;Muscle Fibers;Mutate;Myoblasts;myocyte-specific enhancer-binding-factor 2C;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;NOTCH3 gene;novel;novel therapeutics;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;patient subsets;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Polycomb;pre-clinical;preclinical efficacy;Process;profiles in patients;progenitor;Prognosis;programs;Proliferating;Proteins;Radiation;Recurrence;Recurrent tumor;Relapse;Repressor Proteins;Research;Research Personnel;Resistance;Resolution;Rhabdomyosarcoma;RNA;Role;Sampling;single cell ATAC-seq;single-cell RNA sequencing;standard care;stem;Stem Cell Assay;stemness;Stress;Survival Rate;synergism;Tail;Techniques;Testing;therapy resistant;Time;Transcript;Transcription Coactivator;transcription factor;transcriptomics;Transgenic Animals;tumor;tumor growth;tumor heterogeneity;Undifferentiated;United States;Vincristine;Work;XCL1 gene;Xenograft procedure;Zebrafish

PROJECT_TITLE: Chromatin regulators of stemness and therapy resistance in rhabdomyosarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative For years it has been hypothesized that psychiatric disorders are the result of abnormal trajectories of childhood brain development, though there is little direct evidence to support that hypothesis. The UNC Early Brain Development Study is a longitudinal study that has followed children with imaging and developmental assessments from birth to age 10 years. We will study brain structure and function in these children at 12, 14, and 16 years with MRI to see if we can identify childhood predictors of behavior in adolescence that is considered at risk for psychiatric illness, which will ultimately help target periods of childhood development for early intervention.

PI_NAMEs: GILMORE, JOHN HORACE (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 10 year old;12 year old;16 year old;4 year old;8 year old;Adolescence;Adolescent;adolescent brain development;Age;Anxiety;Attention;Behavior;Behavior assessment;behavior prediction;Behavioral;behavioral outcome;Biological Markers;Birth;Brain;brain abnormalities;Child;Childhood;Cognitive;cohort;Cohort Studies;connectome;Data;Development;Diffusion;disorder risk;early adolescence;early childhood;early detection biomarkers;Early identification;Early Intervention;Enrollment;Environmental Risk Factor;executive function;Functional Imaging;Goals;Human;Image;imaging biomarker;improved;Individual;Individual Differences;individual variation;infancy;innovation;Intervention;Knowledge;Life;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Mental disorders;Modeling;Morphology;National Institute of Mental Health;Neurocognitive;Outcome;Pattern;Phenotype;postnatal period;Predictive Value;prenatal;prevent;Puberty;Reporting;Research;Research Domain Criteria;Rest;Risk;risk mitigation;Risk Reduction;Severity of illness;sex;social;Source;Structure;Testing;white matter

PROJECT_TITLE: The Development of Individual Differences in Adolescent Brain Structure and Risk

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many forms of human disease result from mis-regulation of the pre-mRNA splicing reaction, and this is particularly evident in the nervous system, where amyotrophic lateral sclerosis (ALS), Spinal Muscular Atrophy, Myotonic Dystrophy, and Frontal Temporal Dementia are all disorders of splicing regulation. In this project, we study the mechanisms of splicing regulation by the PTBP and Rbfox protein families, which have been implicated in disorders of cortical development, and in epileptic and autism spectrum disorders, respectively. Despite its broad involvement in neurologic disease, how the cells control splicing is not understood, and this understanding will be essential to the development of splicing targeted therapies.

PI_NAMEs: BLACK, DOUGLAS L (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Alternative Splicing;Amyotrophic Lateral Sclerosis;Architecture;autism spectrum disorder;Binding;Binding Sites;Biochemical;Biochemistry;Biological;Biological Process;Biology;Cell Line;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytoplasm;Development;differentiation protocol;Disease;Epilepsy;Event;Exons;Family;follow-up;Frontotemporal Dementia;Functional disorder;Gene Expression;Genes;genome editing;genome-wide;human disease;Introns;Investigation;LasR protein;Maps;Mass Spectrum Analysis;Mediating;Methods;Molecular;Molecular Mechanisms of Action;mRNA Precursor;mRNA Stability;Myotonic Dystrophy;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neuron development;Neurons;Nuclear;Physical condensation;Polypyrimidine Tract-Binding Protein;Post-Transcriptional Regulation;posttranscriptional;Productivity;programs;Protein Family;Protein Isoforms;Proteins;Reaction;Regulation;Repression;RNA;RNA Splicing;RNA-Binding Proteins;Role;Spinal Muscular Atrophy;Spliceosome Assembly Pathway;stem cell differentiation;Subcellular Fractions;Synapses;targeted treatment;transcriptome;transcriptome sequencing;Translations;Work

PROJECT_TITLE: Mechanisms of Post-transcriptional Gene Regulation by PTB and Rbfox Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The proposed project has significant public health relevance; nearly 30 million Americans will have an eating disorder in their lifetime. These disorders are increasingly recognized to have a biological basis, however neural mechanisms and factors that render individuals responsive vs resistant to treatment, recovery, and remission are poorly understood. This project will characterize behavioral factors and brain mechanisms underlying food choice, associated eating-associated anxiety, and striking clinical features of anorexia nervosa and determine their relationship to treatment responsivity.

PI_NAMEs: SMITH, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Admission activity;American;Amygdaloid structure;Anorexia Nervosa;Anxiety;anxiety reduction;Association Learning;Behavior;Behavior Disorders;Behavior Therapy;Behavioral;Biological;biomarker identification;Body mass index;Brain;Brain imaging;Budgets;Calories;Carbohydrates;career;career development;Caring;Choice Behavior;Clinical;clinical practice;clinically relevant;collaborative environment;Consumption;Data;Data Analyses;design;Disease;Disease remission;Eating;Eating Behavior;Eating Disorders;Emotions;Enteral Feeding;Environment;experimental study;Exposure to;Faculty;Fatty acid glycerol esters;feeding;Food;food avoidance;food consumption;Fright;Functional Magnetic Resonance Imaging;Goals;Grant;habituation;Hospitals;improved;Individual;Inpatients;Institution;instrument;interdisciplinary approach;Interdisciplinary Study;Learning;Length of Stay;Machine Learning;Medical Research;medical schools;Mentors;Nature;neural;neural circuit;neural patterning;Neuroanatomy;neurobehavioral;Neurobiology;neuroimaging;neuromechanism;nutrition;Patients;Pattern;personalized care;personalized medicine;phenomenological models;programs;Protocols documentation;Psychiatry;Psychometrics;public health relevance;Recovery;reduced food intake;Refractory;Relapse;Research;Research Personnel;Resistance;response;restrictive eating;Risk Factors;skills;social;Starvation;Statistical Methods;statistics;Stimulus;Techniques;Testing;Therapeutic;Thinking;Time;tool;Training;Training Programs;Translational Research;Treatment outcome;treatment program;treatment response;United States;Universities;Weight;Weight Gain;weight restoration;Writing

PROJECT_TITLE: Longitudinal Assessment of Eating-related Anxiety in Anorexia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This research investigates how animals integrate different visual cues to detect and respond to their own self-motion. Humans rely on similar visual cues to stabilize gaze when the head or body moves, processing that is disrupted by a variety of neurological diseases. The proposed project will contribute to understanding the suite of algorithms, neural computations, and visual cues that are associated with visual stabilizing behaviors.

PI_NAMEs: CLARK, DAMON ALISTAIR (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Algorithms;Anatomy;Animals;Behavior;behavior measurement;Behavioral;Biological Models;Brain;Brain Diseases;Calcium;Cues;Custom;Detection;detection platform;Diagnosis;driving behavior;Drosophila genus;experimental study;Eye;Eye Movements;feature detection;fly;Frequencies;gaze;Genetic;Geometry;Goals;Head;Human;Image;Impairment;Individual;Lead;Left;Mammals;Measurement;Measures;Modeling;Motion;Movement;Mus;Nervous System Disorder;neural;neural circuit;neuromechanism;neuronal circuitry;Neurons;Neurotransmitters;novel;novel strategies;optic flow;Pathologic Nystagmus;Pathway interactions;Pattern;Primates;Process;Property;Psychophysics;Research;response;Role;scaffold;Sensory;Signal Transduction;spatiotemporal;Stimulus;Testing;tool;two-photon;Visual;Visual Fields;Visual Motion;visual motor;visual processing;visual stimulus;Visual System;voltage;Walking;Work

PROJECT_TITLE: Integrating visual counterevidence to detect self-motion in a small visual circuit

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking;Vaccine Related

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: Understanding how a history of chronic alcohol exposure during adolescence influences viral host defense mechanisms has direct implications for individuals exposed to SARS-CoV-2 and other viral infections. Importantly, sex differences in vulnerability to COVID-19 adverse outcomes are profound, and require well- established animal models for the development of future therapeutics. This project presents a compelling model system to identify the neuroimmune mechanisms underlying early developmental alcohol exposure effects on virally-mediated host defense mechanisms and potential mechanisms of drug-resistance.

PI_NAMEs: DEAK, TERRENCE  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: 15 year old;2019-nCoV;Abstinence;Acute;Adjuvant;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;adverse outcome;Adverse reactions;Age;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;animal model development;antipyretic;Bacterial Antigens;Bacterial Infections;Behavior;Biological Models;Chronic;Complication;COVID-19;COVID-19 patient;COVID-19 susceptibility;cytokine;Data;demographics;Development;Dexamethasone;Disease;Double-Stranded RNA;Drug resistance;early adolescence;early alcohol use;Ethanol;Evolution;Exhibits;experimental study;Female;Fever;FOS gene;functional outcomes;Future;future outbreak;Goals;Hippocampus;Host Defense;Host Defense Mechanism;Human;Immune;immune function;Immunity;Impaired cognition;Impairment;in vivo;Individual;Infection;Inflammatory;LacZ Genes;Life;Lipopolysaccharides;Liver;Lymphocyte;male;Mediating;Modeling;mortality;Neuroimmune;Neuroimmunomodulation;Neurons;novel coronavirus;Organ;Outcome;pandemic disease;pathogen;Pathologic;Peripheral;Phagocytes;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiologic Thermoregulation;Poly C;Poly I-C;preclinical study;Preoptic Areas;Process;Rat Transgene;Rattus;Recording of previous events;Reporting;response;Risk;Rodent Model;Role;SARS-CoV-2 exposure;Schedule;Severities;Severity of illness;sex;Sex Differences;Signal Pathway;Site;Specificity;Spleen;ST5 gene;Testing;Therapeutic;tissue injury;TLR3 gene;TLR4 gene;Vaccination;Vaccines;Variant;Viral;viral outbreak;Virus Diseases;Work;World Health Organization;young adult

PROJECT_TITLE: CNS-mediated fever after Adolescent Intermittent Ethanol


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Replacement therapy using recombinant Factor VIII is the first line of therapy for Hemophilia A, a bleeding disorder and this life-saving therapy is complicated by the development of anti-Factor VIII antibodies, referred as inhibitors and this increase bleeding related morbidity and mortality. Once such responses are established, cost prohibitive therapies are attempted (about $700,000 per patient/per year) with limited success and the proposed research is relevant to NIH’s mission of seeking fundamental knowledge to enhance human health and relevant to public health because the proposal addresses an unmet medical need and is focused on developing novel clinical approaches to reduce and reverse such unwanted immune responses.

PI_NAMEs: BALU-IYER, SATHY VENKAT (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Antibodies;Antibody titer measurement;Autoimmune Diseases;Biological;Blood coagulation;Blood Coagulation Disorders;Canis familiaris;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complication;cost;cost effective;Development;efficacy evaluation;Exogenous Factors;Factor VIII;Foundations;Functional disorder;gene therapy;Half-Life;Health;Hemophilia A;Hemorrhage;Hemostatic Agents;high risk;Human;Hypersensitivity;Immune response;Immunization;immunogenic;immunogenicity;Immunotherapy;improved;inhibitor;innovation;Intravenous;intravenous administration;Investigational Drugs;Knowledge;Laboratories;Life;Lipid Binding;lysophosphatidylserine;Measurable;Measures;Medical;Mission;Modeling;Morbidity - disease rate;mortality;Mus;nanoparticle;National Heart, Lung, and Blood Institute;nonhuman primate;North Carolina;novel;Oral;Outcome;Patient Care;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Phosphatidylserines;Plasma;preservation;prevent;Prevention;Preventive therapy;Primates;Property;Proteins;Protocols documentation;Public Health;recombinant antihemophilic factor VIII;Replacement Therapy;Research;response;Risk;Route;Safety;Study models;success;technology platform;Testing;Therapeutic;therapeutic protein;Toxic effect;Translating;Treatment Protocols;United States National Institutes of Health;Universities

PROJECT_TITLE: Development of tolerogenic Factor VIII as immunotherapy to prevent inhibitor development in Hemophilia A


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome

ORG_CITY: NASHVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative Periodontitis, a disease affecting a large proportion of the population, is associated with a dysbiotic microbial community in which Porphyromonas gingivalis is a major player. As current therapeutic options for periodontitis are only partially successful, therapeutic agents that can specifically target P. gingivalis are attractive and advantageous alternative over conventional antibiotics. Our proposed research will provide a molecular basis for the rational design of agents that can interfere with the initiation and formation of P. gingivalis-associated pathogenic communities.

PI_NAMEs: XIE, HUA  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Affect;African American population;Alveolar Bone Loss;antagonist;Antibiotics;Arginine deiminase;Bacteria;Binding;Biochemical;C-terminal;Cardiovascular Diseases;caucasian American;Cells;Chronic;Communication;Communities;Complex;Data;dental biofilm;Dental Plaque;design;Development;Diabetes Mellitus;Disease;disease disparity;Disease Progression;dysbiosis;Exhibits;Fimbrial Adhesins;Foundations;Genes;genetic approach;Genotype;gingipain;Goals;Gram-Negative Bacteria;Growth;Health;health disparity;Hispanic Americans;in vitro Assay;in vivo;Incidence;Infection;Inflammation;Inflammatory Response;interspecies communication;Invaded;Lead;Membrane Proteins;Microbe;Microbial Biofilms;microbial community;microbial homeostasis;microbial host;microbiome;microorganism;Molecular;mouse model;Mus;National Health and Nutrition Examination Survey;novel;Oral;oral microbial community;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Patients;peptide analog;Peptides;Periodontal Diseases;Periodontitis;periodontopathogen;Pharmacologic Substance;Play;polymicrobial biofilm;Population;Porphyromonas gingivalis;Predisposition;Premature Birth;prevent;Production;prospective;rational design;receptor;Receptor Signaling;Repression;Research;Role;Series;Signal Transduction;Signal Transduction Induction;Signaling Molecule;Streptococcus;Streptococcus cristatus;Streptococcus gordonii;synergism;System;Therapeutic;Therapeutic Agents;Tissues;Virulence;Virulence Factors

PROJECT_TITLE: Development and characterization of anti-P. gingivalis peptides


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_NAME: NEXTSTEP ROBOTICS, LLC

PHR: This proposal finalizes the design of a portable ankle robot as a therapeutic device to reverse foot drop (for the first time) and restore safer independent walking after stroke, and conducts a rigorous randomized clinical trial to establish clinical proof for this new market application. Based on five positive clinical studies using a tethered lab robot, including our randomized study showing 18 sessions on treadmill durably reverses foot drop and restores a safer heel-first foot landing, we finalize a portable ankle robot (AMBLE) for untethered robot use during physical therapy (PTR). Commercial units meeting FDA requirements will reach design freeze the first year (Phase 1); feasibility of which is supported by our precedent battery operated version already showing proof-of-function in stroke patients, leading into Phase II (3-yrs) with a blinded, randomized clinical trial comparing 9-weeks (18 sessions) of PTR vs. PT alone to reverse foot drop based on biomechanical and blinded clinical outcomes, identifying a new market application and filling an unmet need.

PI_NAMEs: HENNESSIE, BRADLEY  (contact);MACKO, RICHARD FRANK;WESTLAKE, KELLY

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: 3-Dimensional;Active Learning;Address;Ankle;arm;Articular Range of Motion;Back;battery life;Biomechanics;Blinded;Calibration;Canes;Caring;Chronic;Client;Clinic;Clinical;Clinical Research;Clinical Trials;clinically relevant;comparative efficacy;Computer software;Computers;cost;Custom;design;Detection;Devices;Diagnostic;Dose;electric impedance;Electric Stimulation;Electronics;Engineering;ergonomics;Event;Exercise;exoskeleton;Exposure to;Failure;fall risk;Feedback;foot;Foot-drop;Freezing;functional electrical stimulation;Gait;Gait abnormality;Generations;Goals;graphical user interface;Guidelines;Heel;hemiparesis;hemiparetic stroke;Human;Impairment;improved;Industrialization;innovation;irritation;Joints;Knee;Left;leg paresis;Legal patent;locomotor tasks;Lower Extremity;Marketing;Measurement;Mechanics;Mediating;meetings;meter;Microprocessor;Mobility disability;Motor;motor control;motor learning;muscle strength;Orthotic Devices;Outcome;Patients;Pattern;Performance;Peripheral;Phase;Physical therapy;Population;portability;post stroke;prediction algorithm;Randomized;randomized, clinical trials;rehabilitation paradigm;Reporting;Research;Resolution;restoration;Robot;robot assistance;robot control;robot exoskeleton;robot rehabilitation;Robotics;Safety;secondary outcome;Self-Help Devices;Severities;Skin;skin irritation;Somatotype;Stroke;stroke patient;stroke survivor;System;Technology;Testing;Therapeutic;therapeutically effective;Time;Torque;Training;Translating;treadmill;treadmill training;treatment effect;trial comparing;usability;Walking;Weight

PROJECT_TITLE: Portable Ankle Robotics to Reverse Foot Drop After Stroke.


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative/Public Health Relevance: Hispanic/Latinx families, especially immigrants, experience twice the rate of food insecurity than non- Hispanic/Latinx families which contributes to disproportionate health disparities. Evidence-based food insecurity interventions, such as the Supplemental Nutrition Assistance Program (SNAP, also known as food stamps), have been demonstrated to improve mental and physical health outcomes for individuals facing food insecurity, yet is an under-utilized program especially among Latinx immigrant communities. The proposed research will develop a SNAP enrollment intervention as a prototype that will advance our understanding for how to identify community-driven strategies for implementing evidence-based social interventions across diverse communities.

PI_NAMEs: BYHOFF, ELENA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adoption;Advisory Committees;Age;Award;career development;Caribbean region;Chronic Disease;Clinical;Communities;community clinic;community collaboration;community engaged research;community engagement;cost;Data;Data Collection;design;Disparity population;Effectiveness;Eligibility Determination;Enrollment;Environment;Evaluation;evidence base;Evidence based intervention;experience;Face;Family;Food;Food Access;food insecurity;formative assessment;Friends;Health;health care service utilization;Health Disparities Research;health disparity;health disparity populations;Hispanic;Housing;Immigrant;Immigrant community;implementation intervention;implementation science;implementation strategy;improved;Individual;innovation;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Latinx;Latinx population;Literature;Maps;Measures;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;Mission;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;Not Hispanic or Latino;nutrition;Outcome;patient oriented;Perception;physical conditioning;pilot test;Population;Population Heterogeneity;Population Sciences;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Predisposition;primary outcome;Process;process improvement;Program Development;programs;prototype;public health relevance;Quality of life;Reduce health disparities;Research;Research Methodology;Research Personnel;Research Training;Safety;Sampling;Science;secondary outcome;Services;social;social interventions;Social isolation;Stress;success;Surveys;Training;Translating;transportation access;uptake;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Increasing SNAP enrollment in a diverse Latinx community


ORG_CITY: VERMILLION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: PROJECT NARRATIVE (RELEVANCE) The development of a new therapeutic strategy to eradicate human immunodeficiency virus type-1 (HIV-1) is an urgent and unmet need. By focusing this proposal on how HIV upregulates certain host proteins to avoid apoptosis and to promote cell survival, we can develop and optimize a new strategy designed to overcome the inherent resistance of HIV-infected macrophages and microglia to viral cytopathicity while sparing uninfected cells. This low risk, high reward approach is fundamentally different from traditional strategies that target HIV itself, and we expect it to be highly complementary with current antiretroviral therapy strategies.

PI_NAMEs: CAMPBELL, GRANT R (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adherence;antagonist;Anti-viral Therapy;antiretroviral therapy;Apoptosis;Apoptotic;Autophagocytosis;base;BCL2 gene;BCL2L1 gene;BCL2L11 gene;BIRC2 gene;BIRC4 gene;Blood Vessels;CASP8 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death Induction;Cell Survival;cell type;Cells;Cessation of life;Data;design;Development;Dose;drug candidate;Goals;high reward;HIV;HIV Antigens;HIV Envelope Protein gp120;HIV Infections;HIV Long Terminal Repeat;HIV resistance;HIV-1;Human;Immune Evasion;immune function;immunodeficiency;improved;Individual;Induction of Apoptosis;Infection;inhibitor;inhibitor-of-apoptosis protein;innovation;Intervention;Investigation;Macrophage;Mediating;Membrane Potentials;Microglia;mimetics;mitochondrial membrane;Modeling;Myelogenous;Myeloid Cells;Neurons;novel;novel therapeutic intervention;novel therapeutics;Patients;Peptides;permissiveness;Pharmaceutical Preparations;pharmacologic;Phenotype;Process;Productivity;programs;Proteins;receptor;Refractory;Regimen;Research;Resistance;response;Rest;Risk;RNA;Role;Site;Source;Testing;Therapeutic;TNF gene;Toxic effect;Translating;Up-Regulation;Viral;viral rebound;Viral reservoir;Virus;Virus Replication;Work

PROJECT_TITLE: Targeting HIV Myeloid Reservoirs in the CNS by IAP and TREM1 Inhibition


ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research will be the first longitudinal study to examine the effects of early-life exposure to breast milk poly- and perfluoroalkyl substances (PFAS) on infant growth trajectories and risk for childhood obesity in the context of the infant gut microbiome and fecal metabolome. Study findings will address a critical gap in our current understanding of breast milk PFAS and their obesogenic effects. Results from this proposal are expected to have significant implications in terms of identifying alterations in gut bacterial species and/or fecal metabolic pathways that contribute to obesity risk. These findings can be used in future novel intervention modalities applicable to Hispanic infants who are at increased risk of early-onset obesity.

PI_NAMEs: ALDERETE, TANYA LYNN (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 2 year old;Actinomyces;Adult;Age;Age Months;Amino Acids;Archives;Bacteria;Bacteroides;bile acid metabolism;Bile Acids;Biological;Blood;Body mass index;Breast Cancer Detection;Breast Feeding;California;Canada;Cardiovascular Diseases;Cardiovascular system;Chemicals;Child;Childhood;cohort;comorbidity;critical period;Data;Development;Disease;drinking water;Dryness;early life exposure;early-onset obesity;energy balance;environmental chemical;Event;Excretory function;experimental study;exposed human population;Exposure to;fatty liver disease;fecal metabolome;Feeding behaviors;Funding;Future;Goals;Growth;gut bacteria;gut microbiome;gut microbiota;high risk;Hispanic;Hispanic Populations;Human;Human Milk;improved;infancy;Infant;infant gut microbiome;insight;Intervention;Lactation;Lactobacillus;Life;Link;lipid biosynthesis;Lipids;Literature;Longitudinal Studies;Maternal Health;Measures;Metabolic Pathway;Metabolic syndrome;metabolomics;Metagenomics;microbial;Milk;Minority Groups;Modality;Mothers;multidisciplinary;multiple omics;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;obesity treatment;obesogenic;Physical activity;physical inactivity;Poly-fluoroalkyl substances;postnatal;Predisposition;Pregnancy;prenatal;prenatal exposure;prevent;Preventive measure;Probiotics;Production;public health priorities;rapid growth;rapid infant weight gain;Reporting;Research;Research Personnel;Risk;Sampling;screening;Source;Spottings;stool sample;Subgroup;Testing;transmission process;underserved community;Unhealthy Diet;United States National Institutes of Health;Volatile Fatty Acids;Weight;Youth

PROJECT_TITLE: Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The training of young scientists that will become the next generation of virologists is essential for our nation's capacity to respond to existing, emerging, and future viral diseases. Furthermore, research on viruses continues to lead to fundamental discoveries in biology. Through the Institute for Molecular Virology and this T32 program, the University of Minnesota-Twin Cities campus has established itself as a leader in virology research, with particular strengths in HIV, influenza virus, herpesviruses, along with emerging and other highly pathogenic viruses.

PI_NAMEs: MANSKY, LOUIS M. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Minnesota;Training Programs;virology

PROJECT_TITLE: Minnesota Training Program in Virology

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator to: (1) advance her research program in neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs); (2) deepen her commitment to mentoring junior clinical scientist pursuing research careers in this area, particularly trainees from underrepresented minority backgrounds; and (3) develop tools to most accurately detect neurocognitive impairment associated with ADRDs among older Spanish- speakers in the United States. These activities will advance the field of ADRD disparities research and support the diversification of the aging research workforce.

PI_NAMEs: MARQUINE, MARIA  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acculturation;Administrative Supplement;Age;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Awareness;bilingualism;Biological Process;California;career;Cellular Phone;Clinical;Clinical Psychology;Cognitive;Cognitive aging;COVID-19 pandemic effects;Data;dementia risk;Development;disadvantaged background;Discrimination;Disparity;dysbiosis;Early identification;early-career faculty;education research;Environmental Risk Factor;experience;Fostering;Funding;gut microbiome;health literacy;high risk;high school;Hispanic;Hispanic Populations;HIV;improved;Infrastructure;innovation;International;Intervention;Joints;K-Series Research Career Programs;Language;Latin America;Latina;Latina Population;Latino Population;Leadership;Mental Health;Mentors;Metabolic syndrome;Midcareer Investigator Award in Patient-Oriented Research;Minority;Minority Groups;minority trainee;mobile computing;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neuropsychological Tests;Neuropsychology;Not Hispanic or Latino;patient oriented research;Pilot Projects;Population;Positioning Attribute;Principal Investigator;Process;programs;protective factors;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Science;Scientist;skills;social culture;Spanish;stem;Time;tool;tool development;Training;Training and Infrastructure;Training Programs;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Research and Mentoring on Neurocognitive Disparities in Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative Oxygen metabolism is mediated by several metalloenzymes, and one of the most complicated and least understood of these is the oxygen-evolving complex in photosystem II containing a manganese-calcium cluster, which is the only enzyme in nature that is capable of oxidizing H2O to O2. This proposal is directed towards using the newly available ultra-fast X-ray free electron laser, to take snapshots of the geometric and electronic structural changes of photosystem II and its metal center, in real time under physiological conditions, to understand the mechanism of water oxidation and oxygen evolution, and extending our studies to the study of other related Fe/Mn/Ni containing metalloenzymes of importance.

PI_NAMEs: YACHANDRA, VITTAL  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;Aerobic;Atmosphere;Biochemical Reaction;Biological;Calcium;Catalytic Domain;Charge;Chemical Structure;Chemicals;Chemistry;cofactor;Complex;cryogenics;Data Collection;Data Correlations;density;Dioxygen;electronic structure;Electronics;Electrons;Enzymes;Evolution;Excision;geometric structure;isopenicillin N;Life;Light;Manganese;Mediating;Membrane Proteins;Metabolism;metalloenzyme;Metalloproteins;Metals;Methane;Natural regeneration;Nature;novel strategies;optical spectra;oxidation;Oxidation-Reduction;Oxygen;photosystem II;Physiologic pulse;Physiological;Process;protein complex;Protein Dynamics;protein structure;Proteins;Reaction;Ribonucleotide Reductase;Roentgen Rays;Role;Sampling;Signal Transduction;Source;Spectrum Analysis;Structure;Temperature;Time;Water;X ray diffraction analysis;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Taking Snapshots of Enzymatic Reactions Using X-ray Crystallography and Spectroscopy

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Sorsby fundus dystrophy is a rare inherited disease caused by mutations in Tissue Inhibitor of Metalloptroteinase-3, that leads to loss of vision and has striking similarities to age-related macular degeneration (AMD). The exact molecular and pathological mechanism(s) that lead to vision loss in either of these conditions has not been identified. Given that mutations in TIMP3 always cause SFD (100% penetrance), knowledge gained from examining the abnormalities in the RPE and retina due to these variations is critical to understanding the pathogenesis of retina/RPE/choroid dysfunction in macular dystrophies. The knowledge gained from these studies will not only contribute to our understanding of fundamental principles of retinal physiology and pathology in SFD, but may also lead to the development of new therapeutic approaches for SFD as well as AMD and other macular degenerative diseases.

PI_NAMEs: ANAND-APTE, BELA  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Age;Age related macular degeneration;Apical;Automobile Driving;Autopsy;autosome;Behavior;Bilateral;Blindness;Cells;Cessation of life;Characteristics;Choroid;Choroidal Neovascularization;Citric Acid Cycle;Clinical;Code;Comparative Study;Data;Defect;Degenerative Disorder;Deposition;Development;Disease;disease model;Elements;Endothelium;Epithelium;Exons;experimental study;Extracellular Matrix;FGF2 gene;Fibroblast Growth Factor;Fibrosis;Functional disorder;Funding;Genes;Health;Hereditary Disease;Human;Hyaluronan;In Vitro;in vivo;in vivo Model;Inherited;inhibitor;Introns;Knowledge;Literature;macula;Macular degeneration;macular dystrophy;Matrix Metalloproteinases;Mediating;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;multiple omics;Mus;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;Nutrient;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Penetrance;Photoreceptors;Physiological;Physiology;Pigment Epithelium;Play;Proteomics;Retina;Role;Signal Transduction;Sorsby's fundus dystrophy;Structure of retinal pigment epithelium;Testing;TIMP3 gene;Tissues;transcriptome sequencing;Transgenic Mice;uptake;Variant;Vision

PROJECT_TITLE: FGF and hyaluronan-mediated alterations in epithelial-mesenchymal transition and metabolism of RPE cells in Sorsby Fundus Dystrophy.


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of this application is to define how specific constituents of the microbiota modulate CHIKV infection, dissemination, and musculoskeletal disease.

PI_NAMEs: DIAMOND, MICHAEL S (contact);FISCHBACH, MICHAEL ANDREW;HANDLEY, SCOTT A.;STAPPENBECK, THADDEUS S

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acquired factor;Acute;Adoptive Transfer;Affect;Age;Alpha Virus;Alphavirus Infections;Anti-viral Agents;Anti-viral Response;Antibiotics;arginase;Arthritis;arthropathies;Bacteroides;Bile Acids;Blood;Bone Marrow;Butyrates;CD80 gene;CD86 gene;Cells;chikungunya infection;Chikungunya virus;Chronic;Chronic Disease;Circulation;Clinical Trials;Clostridium;commensal bacteria;Cues;Culicidae;Data;Dendritic Cells;Diamond;Disease;Disease Progression;Epidemic;experimental study;fecal transplantation;Focal Infection;Genetic;Germ-Free;Goals;gut bacteria;gut microbiota;House mice;Human;human disease;Immune;immune cell infiltrate;Immune response;Immunity;immunological status;Immunologics;Infection;Infiltration;Inflammation;Inflammatory Response;Innate Immune Response;Interferon Type I;Interferons;joint inflammation;Joints;Knockout Mice;Licensing;Link;Mediating;Metabolic;Metagenomics;Microbe;microbial;microbiome;microbiota;migration;Molecular;monocyte;Morbidity - disease rate;multidisciplinary;Mus;Musculoskeletal;Musculoskeletal Diseases;mutant;Natural Immunity;novel therapeutics;Oral;oral supplementation;Pathogenesis;Persons;Phylogenetic Analysis;Polyarthritides;prevent;Prevention;Production;receptor;reconstitution;Research Personnel;response;Risk;Role;Sepsis;Severities;Shapes;Signal Transduction;Site;Testing;Tissues;TLR7 gene;TNF gene;trafficking;Transgenic Mice;transmission process;Vaccines;vector mosquito;Viral;Viral Load result;Viral Pathogenesis;Viremia;Virus;Virus Diseases;Virus Replication;Volatile Fatty Acids

PROJECT_TITLE: Gut Microbiota Modulation of Chikungunya Virus Infection and Pathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Cancer;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Program Narrative This project is clinically relevant to development multiple sclerosis therapy because the Hectd3 ubiquitin E3 ligase regulates the severity of the experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis mouse model. We found that loss of Hectd3 reduced EAE severity. The proposed study will identify chemical probes to investigate Hectd3 and its implication in multiple sclerosis.

PI_NAMEs: AVRAM, DORINA ;LI, HONGMIN  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Active Sites;Adverse effects;Affinity;analog;attenuation;Autoimmune;Autoimmune Diseases;Bacterial Infections;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biology;burden of illness;cancer drug resistance;cancer therapy;Cells;Central Nervous System;chemical synthesis;Chemicals;Chronic;clinically relevant;Complement;Crystallography;cytokine;Defect;Demyelinations;Development;Disease;Drug Kinetics;Ensure;Enzymes;Experimental Autoimmune Encephalomyelitis;experimental study;fetal;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;high throughput screening;human model;Immune system;Immunologics;immunoregulation;Immunotherapy;improved;in silico;In Vitro;in vivo;infancy;Inflammatory;Informatics;inhibitor;innovation;Lead;Ligase;Liver Failure;Luciferases;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modeling;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Neoplasm Metastasis;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;Play;Polyubiquitination;programs;Property;Protocols documentation;Public Health;Publishing;Relapse;Research;response;Role;screening;Severities;side effect;Signal Transduction;small molecule libraries;Solid;Specificity;Stat3 Signaling Pathway;Structure;Structure-Activity Relationship;Substrate Interaction;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy development;Toxic effect;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase implicated in multiple sclerosis

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PROVIDENCE

ORG_DEPT: SURGERY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it would provide crucial information to inform the design of bundled payment programs implemented by the Centers for Medicare and Medicare Services. Given the size of the Medicare program and the national implementation of bundled payment, even minor improvements to bundled payment programs have the potential to improve outcomes for thousands of older Americans. Understanding the impact of bundled payment for coronary artery disease is particularly important to older Americans because they have greater clinical risk and are more susceptible to poor outcomes related to common cardiovascular procedures.

PI_NAMEs: RYAN, ANDREW M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acute;acute care;Address;Adult;Affect;American;Benchmarking;bundled payment;Cardiac;Cardiac rehabilitation;Cardiac Surgery procedures;Cardiovascular Surgical Procedures;Cardiovascular system;care coordination;Caring;Cessation of life;clinical risk;Coronary;Coronary Arteriosclerosis;Coronary Artery Bypass;Coupled;COVID-19;COVID-19 pandemic;Data;Data Linkages;data registry;design;Econometric Models;Exclusion;expectation;Frequencies;Future;Health Expenditures;Hospitals;improved;improved outcome;Incentives;innovation;Inpatients;Institution;Link;Measures;Medical;Medicare;Medicare claim;Minor;mortality;novel;older adult;Outcome;Outpatients;Patient risk;Patient Selection;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Performance;Policies;Predisposition;Price;Procedures;profiles in patients;programs;Public Health;Registries;Research;revascularization;Risk;Role;Services;Severities;Societies;Statistical Methods;System;Testing;Thoracic Surgeon;Time;Variant;Voluntary Programs

PROJECT_TITLE: The Effects of Bundled Payment on Acute Cardiovascular Outcomes Among Older Adults

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Prevention;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: 8. PROJECT NARRATIVE Apolipoprotein L1 (APOL1) risk variants may contribute to African American living kidney donors’ even greater (3.3-fold) risk of end-stage renal disease post-donation than white living kidney donors. However, transplant physicians do not consistently use APOL1 genetic testing or counsel African American living donor candidates about APOL1, which may undermine candidates’ ability to give informed consent about donating and exacerbate health disparities in living donation and transplantation. By evaluating the effectiveness of a culturally competent APOL1 genetic testing program, the proposed study will provide valuable knowledge about the potential to rapidly scale up APOL1 testing nationally as a novel and ethical approach to protect African American living donors’ safety and enhance their informed consent.

PI_NAMEs: AGRAWAL, AKANSHA  (contact);FRIEDEWALD, JOHN J;GORDON, ELISA J

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Adopted;Adoption;African American;African ancestry;Alleles;Altruism;Apolipoproteins;Artificial Intelligence;Bioethics;chatbot;Chicago;Clinical;clinical practice;Clinical Practice Guideline;Communities;community advisory board;Conflict (Psychology);Counseling;cultural competence;Data;Decision Making;design;Dialysis procedure;Donor person;effectiveness evaluation;Effectiveness of Interventions;End stage renal failure;Ensure;Ethics;Evaluation;Family;Friends;Fright;Future;Genetic;Genetic Counseling;genetic counselor;genetic information;genetic testing;Genomics;Genotype;Health;health disparity;Health Personnel;high risk;Hospitals;implementation evaluation;implementation intervention;implementation outcomes;implementation science;improved;Informed Consent;Intervention;Kidney Transplantation;Knowledge;literacy;Living Donors;living kidney donor;Medical;Medical Genetics;Medicine;mobile application;Modeling;novel;optimal treatments;Outcome;Patients;Physicians;Population;Populations at Risk;Prevalence;programs;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Renal function;Reporting;Risk;risk variant;Safety;satisfaction;scale up;shared decision making;skills;success;Testing;Time;Training Programs;transplant centers;Transplantation;United States National Institutes of Health;Universities;Variant;Washington;willingness;Work

PROJECT_TITLE: Integrating a culturally competent APOL1 genetic testing program into living donor evaluation


NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: BUFFALO

ORG_NAME: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST

PHR: Project Narrative  The proposed research is relevant to public health because it focuses on functional and mechanistic studies of a transport protein – OATP1B1 that is involved in the uptake of various endogenous molecules and drugs into hepatocytes, which is the first step in the process of drug processing in the liver. Due to the promiscuity of OATP1B1, various co-administered drugs could compete with each other, resulting in elevated plasma levels of the drugs, and risking adverse side effects. Also, some cancers overexpress OATP1B1 and it is the conduit through which anti-cancer medications or hormones that promote the growth of the cancers enter the cells. Thus, deciphering the structure and mechanism of OATP1B1 would advance our understanding of these processes, and aid in drug design that minimizes drug-drug interactions, which is relevant to the NIH’s mission.

PI_NAMEs: PAZ, AVIV  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Affect;anti-cancer;Bile Acids;Binding Sites;Biochemical;Biological Assay;Breast Cancer cell line;Carrier Proteins;Cell Line;Cell membrane;Cells;Cellular Assay;Charge;Chemistry;Communities;Complex;Contrast Media;Coupled;Coupling;Cryoelectron Microscopy;Data;Data Reporting;Disease;docetaxel;Docking;Doxorubicin;Drug Design;Drug Interactions;Drug Prescriptions;Epitopes;Excretory function;Exhibits;Family;Food;Goals;Growth;Health;Hepatic;Hepatocyte;Homologous Gene;Hormones;Human;hydrophilicity;Image;innovation;insight;Ion Transport;Ions;irinotecan;Isomerism;Kinetics;Knowledge;Life;Ligand Binding;Ligands;Literature;Liver;Magnetic Resonance Imaging;Malignant Neoplasms;mathematical model;Mediating;member;Membrane;Membrane Transport Proteins;Metabolic Clearance Rate;Metabolism;Methodology;Methotrexate;Microscopic;Mission;Modeling;Molecular Conformation;molecular dynamics;Motion;novel;Nutrient;OATP Transporters;older adult;overexpression;Paclitaxel;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Plasma;Play;Polymorph;Post-Translational Protein Processing;Process;Property;Prostaglandins;prostate cancer metastasis;Protein Isoforms;protein purification;protein reconstitution;protein structure;Proteins;proteoliposomes;Protocols documentation;Public Health;Records;Reproducibility;Research;Risk;Role;side effect;Signaling Molecule;Solid;Specificity;stem;structural determinants;Structure;Sulfate;Testing;Therapeutic;Therapeutic Effect;Tyrosine Kinase Inhibitor;United States National Institutes of Health;uptake;voltage;Xenobiotics

PROJECT_TITLE: Structure meets function for OATP1B1, a transporter involved in the uptake of endogenous and xenobiotic materials and drugs

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: QUITO

ORG_COUNTRY: ECUADOR

ORG_FIPS: EC

ORG_NAME: PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR

PHR: PUBLIC HEALTH NARRATIVE Malaria elimination is a reachable goal in many countries of the world. Nevertheless, many countries have had a regression in their advances and are battling to get malaria elimination back on track. Some of the explanations for these difficulties are the presence of asymptomatic reservoirs and infection importation from neighboring countries. This project will investigate the relative importance of asymptomatic reservoirs, infection importation, and host immunity in the context of reduced parasite antigenic diversity to understand transmission dynamics in northwest Ecuador, a model pre-elimination setting.

PI_NAMEs: SAENZ, FABIAN ERNESTO (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: acquired immunity;Alleles;Annual Reports;Antigenic Diversity;Antigens;Appearance;Area;Back;Biological Assay;biosignature;Border Crossings;Characteristics;Cities;Clinical;Colombia;Colombian;Country;cross reactivity;Disease;Disease Outbreaks;disease transmission;Ecuador;Epidemiology;experimental study;Exposure to;Falciparum Malaria;Genetic;Genetic Markers;Genetic Recombination;Genome;genome sequencing;Genomics;Genotype;Goals;Growth;Immune response;Immunity;Immunoglobulin G;improved;In Vitro;in vitro Assay;Individual;Infection;innovation;Knowledge;Maintenance;Malaria;malaria transmission;Measurement;Modeling;Natural Immunity;new outbreak;novel;Outcome;Parasites;Periodicals;Plasma;Plasmodium falciparum;Play;Population;Prevalence;prevent;Province;Public Health;Recombinants;Recording of previous events;Reporting;response;Role;Sampling;serological marker;Serology;Serology test;Severities;Severity of illness;Signal Transduction;South American;Stress;transmission process;Validation;whole genome

PROJECT_TITLE: Genomics and sero-epidemiology of Plasmodium falciparum malaria in a pre-elimination setting

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative The goal of the Harvard-Vision Clinical Scientist Development Program is to provide an academically and supportive environment to enable qualified early-stage clinician-scientists to engage in a structured and mentored learning experience that will enable them to achieve career advancement and independence through a rigorous program of didactic courses, research, and other professional development activities.

PI_NAMEs: DANA, REZA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Advisory Committees;Area;Award;Basic Science;Benchmarking;Bioethics;Biometry;Clinical;Clinical effectiveness;Clinical Sciences;Degree program;Development;Doctor of Philosophy;Educational Curriculum;Enrollment;Environment;experience;Faculty;Funding;Funding Agency;Grant;Growth;Immersion;Lead;Learning;Link;medical schools;meetings;member;Mentored Clinical Scientist Development Program;Mentors;notch protein;Ophthalmology;Peer Review;Productivity;Program Development;programs;Qualifying;recruit;Reporting;Research;Research Design;responsible research conduct;Scholars Program;Science;Scientist;Structure;Training;Training Programs;Translational Research;United States National Institutes of Health;virtual;Vision;Vision research;vision science;Writing


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE T-cell lymphomas (TCLs) are highly diverse and patients with relapsed disease have a dismal prognosis. The PI3K-δγ inhibitor duvelisib induces response in 60% of patients with TCL through tumor cell-intrinsic and immunomodulatory mechanisms, but nearly all responders ultimately develop resistance. We hypothesize that the integration of spatial data, including neighborhood analyses to identify para- and juxtacrine interactions, with genetic and transcriptional alterations will inform predictive models for duvelisib response and nominate mechanisms of de novo and acquired resistance that can aid therapeutic selection and broadly applied across tumor types.

PI_NAMEs: NIRMAL, AJIT JOHNSON  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoption;Aftercare;Architecture;Area;Biological Assay;Biological Markers;Biology;Cancer Biology;Cancer Center;cancer type;Cell Communication;Cells;Characteristics;Classification;Clinical;clinical practice;Clinical Trials;cohort;Communication;Complex;Computational Biology;Computer Analysis;computerized tools;Conditioned Reflex;Data;data integration;data modalities;Data Science;design;Development;Drug Combinations;Drug resistance;Ecosystem;Engineering;exome;exome sequencing;experience;Exposure to;Genetic;Genetic Transcription;gradient boosting;Immune;immunoregulation;improved;inhibitor;innovation;Institution;interest;JAK1 gene;JAK2 gene;Knowledge;Lead;Leadership;Learning;Link;liquid crystal polymer;Logistic Regressions;machine learning model;Malignant - descriptor;Methods;model building;Modeling;Molecular;molecular modeling;mRNA Expression;multiplexed imaging;Mutation;Neighborhoods;neoplastic cell;neural network;Non-Malignant;novel;outcome prediction;paracrine;patient response;patient stratification;Patients;Pattern;Performance;Pharmaceutical Preparations;Phase;Phenotype;PIK3CG gene;Play;Positioning Attribute;precision oncology;predicting response;prediction algorithm;Prediction of Response to Therapy;predictive marker;predictive modeling;Prognosis;programs;random forest;Recurrent disease;Relapse;Research;Resistance;Resistance development;resistance mechanism;response;Role;Sampling;Sensitivity and Specificity;Signal Transduction;single cell technology;skills;spatial integration;spatial relationship;Specimen;spectrograph;statistical and machine learning;support vector machine;T-Cell Lymphoma;Techniques;Technology;Testing;Therapeutic;therapy resistant;tool;Training;Training Programs;Transcription Alteration;transcriptome sequencing;transcriptomics;translational research program;treatment response;tumor;Validation;Voting

PROJECT_TITLE: Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE HIV and associated co-morbidities are prevalent in South Africa, with immunologically mediated adverse drug reactions (IM-ADRs) affecting one in five people treated for HIV and associated complications, such as tuberculosis (TB). We will establish the largest South African network of phenotype and causality adjudicated cases of severe IM-ADRs paired with a biorepository of DNA, PBMCs, blister fluid cells, plasma and skin from adults and children. This will be used to 1) identify HLA and other genetic risk factors associated with these IM- ADRs related to prevalent drugs used to treat HIV and its complications; and 2) elucidate the impact of IM-ADRs on HIV and TB treatment outcomes, as well as long-term complications of IM-ADRs.

PI_NAMEs: MEINTJES, GRAEME AYTON (contact);PHILLIPS, ELIZABETH

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: abacavir;adjudication;Adult;adverse drug reaction;Adverse reactions;Affect;African;Age;AIDS prevention;Alleles;Area;Autoimmune Diseases;biobank;Biological;Blindness;Bulla;Carbamazepine;Caring;Cause of Death;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Count;Cells;Child;co-infection;cohort;Collaborations;Collection;comorbidity;Complex;Consent;constriction;Country;Cutaneous;Disease;DNA;Drug resistance in tuberculosis;Drug Tolerance;Drug usage;Early Diagnosis;Early treatment;Economic Burden;efavirenz;Eosinophilia;Ethambutol;Etiology;Europe;European;experience;follow-up;Genes;Genetic;genetic association;Genetic Risk;genetic risk factor;Genotype;Health Care Costs;High Prevalence;HIV;HIV/TB;HLA-A gene;HLA-B Antigens;HLA-C Antigens;Hospitalization;Hypersensitivity;Immune;Immunologic Factors;Immunologics;Impairment;improved;Individual;Infrastructure;Ingestion;International;isoniazid;Liquid substance;Long term physical disability;long-term sequelae;Measurement;Measures;Mediating;member;Mental disorders;Mental Health;Morbidity - disease rate;mortality;multi-ethnic;Nevirapine;North America;novel;Organ;Other Genetics;Outcome;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;physical conditioning;Plasma;Population;Predisposition;prevent;Prevention;Prevention strategy;Preventive;Procedures;prospective;Pyrazinamide;Quality of life;Race;Reaction;Recurrence;Regimen;Registries;Research;Resolution;Resource-limited setting;Resources;Rifampin;Risk Factors;risk variant;Salivary;Sampling;screening;sex;Skin;South Africa;South African;southeast Asian;Sputum;Stevens-Johnson Syndrome;success;Symptoms;Testing;Therapeutic;Time;tool;Toxic Epidermal Necrolysis;Translations;treatment optimization;Treatment outcome;Treatment Protocols;treatment strategy;Trimethoprim-Sulfamethoxazole;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Universities;Validation;Viral;Viral Load result;Virus Diseases;Vision

PROJECT_TITLE: Immune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study)


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The "Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda” (MITHU) program builds on a 32-year training record of Case Western Reserve University (CWRU) with partners at Makerere University (MU). This competing renewal of the MITHU program provides biomedical training in molecular microbiology and immunology at the MSc level at MU and as a Sandwich PhD level between MU and CWRU.

PI_NAMEs: BOOM, W. HENRY  (contact);JOLOBA, MOSES LUTAAKOME

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Biomedical Research;Collaborations;college;COVID-19 pandemic;Diagnosis;Distance Learning;Doctor of Philosophy;doctoral student;Educational workshop;Emerging infection;Epidemic;Faculty;faculty mentor;Funding;Health Sciences;HIV;HIV/TB;Immunology;improved;Infrastructure;Institution;Internet;Journals;lectures;meetings;Mentors;Methods;Microbiology;Molecular;next generation;pathogen;Prevention;programs;Research;research faculty;Research Personnel;Research Training;Rotation;Schools;Science;Scientist;Students;success;Training;Training Programs;Uganda;Universities;Work

PROJECT_TITLE: Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda (MITHU)


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: ANCHORAGE

ORG_NAME: UNIVERSITY OF ALASKA ANCHORAGE

ORG_STATE: AK

PHR: Project Narrative The University of Alaska Anchorage (UAA) is a diverse primarily undergraduate institution located in the largest population center in Alaska. The UAA Biomed U-RISE will prepare students from underrepresented and disadvantaged groups to seek graduate degrees in biomedical sciences through enhanced training, engaged mentoring, rigorous undergraduate research and presentation opportunities, and professional networking. These students will be well-positioned to get accepted and successfully complete Ph.D. programs and to address the larger need for diversity in the biomedical workforce.

PI_NAMEs: BURKE, TRACEY KATHLEEN (contact);MARTINSON, HOLLY A

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Alaska;Alaska Native;Bachelor's Degree;Biology;Biomedical Research;career;Censuses;Chemistry;cohort;demographics;Discipline;Ethnic Origin;evidence base;experience;falls;Fostering;Foundations;innovation;Institution;interest;Laboratories;minority student;Natural Sciences;Outcome;Paper;peer coaching;Population;posters;programs;psychosocial;racial minority;Readiness;recruit;Research;Science;skill acquisition;Students;summer research;symposium;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: U-RISE at University of Alaska Anchorage ("Biomed U-RISE")

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE  In a previous cycle, we showed that, in older hypertensive subjects, there is an optimal blood pressure (BP) that maximizes cerebral blood flow (CBF) and decreases the risk of white matter damage. Despite these new discoveries, there is a large variance in CBF and cognition due factors other than age and BP, suggesting the need for further fine-tuning of the model for optimal BP. In this competitive renewal of our R01 HL111724 we will examine whether incomplete variants of circle of Willis increase the risk of hypoperfusion and Alzheimer's disease pathology in subjects with hypertension.

PI_NAMEs: GLODZIK, LIDIA  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: abeta deposition;Acute;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Anatomy;Anti-Hypertensive Agents;arterial spin labeling;Biological Markers;Blood flow;Blood Pressure;blood pressure reduction;Blood Vessels;Brain;cerebrovascular;Cerebrovascular Circulation;Chronic;Circle of Willis;Circulation;Clinical Trials;Cognition;Cognitive;Compensation;Data;Disease Marker;Enrollment;Evaluation;Failure;follow-up;Goals;High Prevalence;Hippocampus;human very old age (85+);Hypertension;hypertension control;hypertensive;hypoperfusion;Hypoxia;Impairment;Inflammation;innovation;Intracranial Atherosclerotic Disease;Lesion;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Measurement;Measures;Modeling;Motion;National Heart, Lung, and Blood Institute;novel;Older Population;Outcome;Pathology;Pathway interactions;Perfusion;Population;Positron-Emission Tomography;pressure;Probability;Randomized;Regulation;Reporting;Research;Risk;Slice;tau aggregation;tau Proteins;tau-1;Testing;Time;ultra high resolution;United States National Institutes of Health;Variant;Vascular blood supply;Vascular System;vertebral artery;white matter;white matter damage

PROJECT_TITLE: Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer's disease biomarkers in hypertension

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]