NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: PROJECT NARRATIVE The UAB Blazer BRAIN (Broadening Representation And Inclusion in Neuroscience) Summer Program at the University of Alabama at Birmingham (UAB) focuses on increasing diversity in the neuroscience workforce through providing an outstanding summer research and educational experience for undergraduates earning their STEM degree at partner HBCUs and throughout the southeast U.S. This experience will instill confidence and excitement in these talented students and increase their desire for a career as a neuroscience researcher.

PI_NAMEs: GAVIN, CRISTIN F;SHACKA, JOHN J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academic support;Acceleration;Administrator;Admission activity;Advisory Committees;Advocacy;Affect;African American;Alabama;Biomedical Research;Black race;Brain Diseases;career;Career Choice;career life balance;Communication;Communities;Dedications;design;Development;disability;Disabled Persons;disabled students;disadvantaged background;Discipline;Diverse Workforce;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;Education;Educational process of instructing;Enrollment;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Faculty;faculty mentor;faculty research;faculty support;forging;Fostering;Funding;Future;Goals;Graduate Education;graduate school;graduate student;Grant;Hispanic;Historically Black Colleges and Universities;improved;Infrastructure;Institution;interest;Interview;Investments;Laboratories;Latino Population;Leadership;Learning;Location;matriculation;medical schools;meetings;Mentors;Mentorship;Minority Groups;Mission;Modeling;National Institute of General Medical Sciences;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Neurosciences Research;peer;peer coaching;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Process;programs;Readiness;recruit;Research;research faculty;Research Personnel;Research Project Grants;Scholars Program;Science;Scientist;Secure;Services;skills;Social support;Societies;Southeastern United States;Strategic Planning;Structure;student mentoring;Students;success;summer program;summer research;symposium;Talents;Training;Training Support;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The Consortium for Increasing Research and Collaborative Learning Experiences (CIRCLE) program will create a distance research network to expand scientific research interest and skills in underserved communities throughout the US Pacific region. This will strengthen STEM career pathways, expand public knowledge of science and help ensure a maximally large and diverse workforce to meet the biomedical, behavioral and clinical research needs of the United States.

PI_NAMEs: WITHY, KELLEY MARIE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academic advising;Age;Area;Award;Behavioral Research;Biomedical Research;career;Career Choice;Clinical Research;Collaborations;college;Diverse Workforce;Education;Educational workshop;Ensure;essays;experience;Funding;Goals;Grant;health science research;Health Sciences;High School Student;Incubated;Individual;Infrastructure;interest;Interview;Knowledge;Learning;Location;Mentors;Mentorship;Middle School Student;programs;Research;Research Training;Science;science education;Site;skills;STEM career;Students;Testing;tool;Training;twelfth grade;underserved community;United States;video chat;Vocational Guidance;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Nearly half of patients with heart failure die within 5 years of diagnosis. A number of medicines for heart failure target a protein called PKG which resides in heart muscle and in blood vessels. Turning on PKG preserves heart muscle strength but often causes excess and unsafe drops in blood pressure. We discovered that a protein called MLK3 cooperates with PKG to improve failing heart muscle but does not carry out the PKG blood pressure reducing effect. This project will determine how MLK3 protects heart muscle without affecting blood pressure, so that this knowledge could be used to develop new treatment strategies for heart failure which avoid excess low blood pressure.

PI_NAMEs: BLANTON, ROBERT MORRIS (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Abnormal Cell;Acute;Affect;Aorta;aorta constriction;arterial stiffness;Blood Pressure;blood pressure reduction;blood pressure regulation;Blood Vessels;Cardiac Myocytes;Cells;Chronic;Clinical;Compensation;Cyclic GMP-Dependent Protein Kinases;Diagnosis;Drops;Echocardiography;Fibrosis;Genetic;Heart;Heart failure;heart failure with reduced ejection fraction;heart preservation;hemodynamics;Human;Hypertension;Hypertrophy;Hypotension;Hypotensives;Impairment;Implant;improved;improved outcome;In Vitro;in vivo;inhibitor;kinase inhibitor;Knowledge;Lead;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Left Ventricular Function;Left Ventricular Hypertrophy;Left Ventricular Remodeling;Left ventricular structure;loss of function;Luciferases;Measures;Mediating;Medicine;mixed lineage kinase 3;Modeling;Molecular;mortality;Mus;muscle strength;Myocardial;Myocardial Infarction;Myocardium;Nature;Nitrates;novel;novel therapeutic intervention;novel therapeutics;nuclear factors of activated T-cells;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Physiologic intraventricular pressure;Physiologic pulse;preclinical study;pressure;Process;programs;Protein Kinase;Proteins;Regulation;Relaxation;Reporter;response;Role;Signal Transduction;Signaling Protein;sildenafil;Smooth Muscle Myocytes;Stress;Syndrome;Tamoxifen;Telemetry;Testing;therapeutic candidate;Therapeutic Effect;Tissues;transgene expression;Transgenes;Treatment Failure;valsartan;Vascular Smooth Muscle;Vasodilation;Ventricular;Ventricular Remodeling

PROJECT_TITLE: Investigating Mixed Lineage Kinase 3 as a blood pressure-independent protein kinase G1 effector in heart failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: DOYLESTOWN

ORG_NAME: FOX CHASE CHEMICAL DIVERSITY CENTER, INC

ORG_STATE: PA

PHR: Chagas disease is caused by the parasite Trypanosoma cruzi (T. cruzi) and spread by Triatominae, or "kissing bugs". It is endemic in South America but has spread to people living elsewhere due to immigration of infected individuals and also travel to endemic regions. While current treatments are relatively toxic, we have found a new class of small molecules that kill multiple stages of the T. cruzi life cycle without apparent toxicities, thus affording hope for the discovery of a safer and more effective cure for patients who suffer from this disease.

PI_NAMEs: MCDONNELL, MARK E (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: absorption;Acute;Adverse event;Africa;analog;Antiparasitic Agents;Benznidazole;Binding Proteins;Biochemical;Biological Assay;Blinded;Blood;Caco-2 Cells;Caring;Cells;Central America;Cessation of life;Chagas Disease;Chemicals;Chronic;Chronic Phase;Collaborations;cost;cytotoxicity;Data;Dedications;Defecation;Dementia;Deposition;Dilated Cardiomyopathy;Disease;Drug Screening;Drug usage;Effectiveness;Ensure;Esophagus;Europe;Evaluation;Excretory function;Exhibits;Federal Government;feeding;flu;Foundations;Free Radicals;functional group;G-Protein-Coupled Receptors;gastrointestinal system;Goals;Heart;Heart Aneurysm;Human;Immigration;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;infection rate;Insect Bites;Insecticides;interest;International;Investigational New Drug Application;Investments;Lead;lead optimization;Legal patent;Life Cycle Stages;Liver Microsomes;Marketing;Mastigophora;Megacolon;Metabolic;Metabolism;migration;mouse model;Mus;National Institute of Allergy and Infectious Disease;neglect;neglected tropical diseases;Nervous System;Neuritis;Neurons;New Agents;New York;Nifurtimox;North America;novel;novel therapeutics;Oral;Parasites;Patients;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Plasma Proteins;pre-clinical;programs;Property;Public Health;Qualifying;Recommendation;Research;research facility;Research Priority;Resistance development;Resources;Review Literature;Running;Scotland;screening;Series;Site;Small Business Innovation Research Grant;small molecule;South America;Spain;Stream;Structure;Symptoms;Testing;Text;Toxic effect;Toxicity Tests;Travel;Triatominae;Tropical Disease;Trypanocidal Agents;Trypanosoma cruzi;Universities;Vaccines;vector transmission;Viral Hemorrhagic Fevers;voucher

PROJECT_TITLE: Trypanocidal Agents that Kill Multiple Stages of the Trypanosoma cruzi Life Cycle


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: JOHNSON CITY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Chemotherapy remains a standard neoadjuvant therapy for triple-negative breast cancer (TNBC), but chemoresistance is the major cause of the chemotherapeutic failure of TNBC patients. Herein, we found dual serine/threonine and tyrosine protein kinase (DSTYK) is responsible for the chemoresistance of TNBC. Therefore, we will illustrate the function by which DSTYK promotes chemoresistance and try to explore an exosome-mediated strategy for neutralizing DSTYK’s function and attenuating the chemoresistance in TNBC.

PI_NAMEs: JIANG, YONG  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adjuvant Chemotherapy;Apoptosis;Attenuated;Bax protein;Biochemical;Biological Models;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;Cell Death;Cell Death Inhibition;Cell model;Cell surface;Cell Survival;Cells;Cessation of life;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic;Clinical;CRISPR/Cas technology;Data;Data Set;Death Rate;Development;engineered exosomes;Exhibits;exosome;Extracellular Signal Regulated Kinases;Failure;Foundations;improved;In Vitro;in vivo;Incidence;Inhibition of Apoptosis;inhibitor;insight;Knock-out;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediating;Methods;Modeling;Mouse Mammary Tumor Virus;mouse model;Mus;Neoadjuvant Therapy;Neoplasm Metastasis;novel;novel strategies;patient derived xenograft model;personalized chemotherapy;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;polyoma middle tumor antigen;pre-clinical;Pre-Clinical Model;pro-apoptotic protein;Probability;Prognosis;Prognostic Marker;Protein Kinase;Protein Microarray Assay;Proteins;Relapse;Residual state;Resistance;Resistance development;Role;Sampling;Serine;Small Interfering RNA;Statistical Data Interpretation;TACSTD2 gene;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;tool;Transgenic Mice;Transgenic Organisms;translational study;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Markers;Tumor Promotion;Woman;women's diagnosis

PROJECT_TITLE: Enhancing chemotherapeutic efficacy in triple-negative breast cancer via DSTYK silence


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE Relevance As the proportion of older adults in the population continues to expand, magnifying the relative impact of their decisions, it is increasingly imperative to better understand changes in decision making across the life span before and throughout all stages of significant cognitive impairment related to Alzheimers Disease and related dementias. Increasing interdisciplinary research combining psychology, neuroscience/neurology, medicine, and economics has tremendous potential for increasing translation of science for real-world impact to better understand and alleviate the burden of Alzheimers Disease and related dementias. The long-term goal of this network is to conduct integrative and multidisciplinary research that contributes directly to interventions aimed at improving health and well being in the daily lives of aging adults.

PI_NAMEs: LIGHTHALL, NICHOLE ;SEAMAN, KENDRA LEIGH (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Awareness;Basic Science;behavior measurement;Behavioral;Biological;Brain imaging;career;career networking;Clinical;Clinical assessments;Clinical Research;Collaborations;Collection;computer science;data access;Data Aggregation;Data Set;data sharing;Decision Making;Development;Discipline;Documentation;Economics;Educational workshop;effective intervention;Ensure;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Health;imaging modality;Impaired cognition;improved;Individual;Institution;Interdisciplinary Study;interest;Intervention;Investments;Leadership;life span;Link;Measures;Medicine;meetings;member;Mentorship;Methodology;Methods;Modeling;multidisciplinary;Neurology;Neurosciences;older adult;Patient Recruitments;Personal Satisfaction;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Psychology;Public Health;Qualitative Research;recruit;Recruitment Activity;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;senior faculty;skill acquisition;social;Sociology;Students;success;Supercomputing;support network;symposium;theories;tool;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Update;Woman;Work

PROJECT_TITLE: Research Network on Decision Neuroscience and Aging


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Pancreatic cancer is an aggressive disease with dismal survival rates. We propose to evaluate a PET tracer to quantify a targetable and potentially prognostic feature of PDAC, oxidative phosphorylation (OXPHOS), in preclinical studies. Since OXPHOS activity is associated with progression of certain high-risk, premalignant lesions, accumulation of 18F-BnTP, a potential biomarker of OXPHOS activity, may illuminate indeterminate lesions requiring immediate intervention and allow optimization of therapeutic regimens targeting OXPHOS activity.

PI_NAMEs: MANNING, HENRY CHARLES (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: adjudication;Age;Allografting;ATP Synthesis Pathway;Basic Science;Biological Models;Biological Process;Clinical Sciences;clinical translation;Clinical Trials;Complex;Data;Disease;Dose;drug development;Drug Targeting;Early Diagnosis;Future;Genes;Genetic;Genetically Engineered Mouse;high risk;Histopathology;Human;improved;in vivo;in vivo Model;Incidence;inhibitor;inhibitor therapy;innovation;Intervention;KPC model;Label;Lesion;Loss of Heterozygosity;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Membrane Potentials;Mitochondria;mitochondrial membrane;Modeling;Molecular;mouse model;Mucinous Neoplasm;Mus;mutant;Mutate;Mutation;new therapeutic target;Operative Surgical Procedures;Oxidative Phosphorylation;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Papillary;Pathology;patient derived xenograft model;Patients;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetic model;Phenotype;Phosphorylation Inhibition;Physicians;Positron-Emission Tomography;potential biomarker;precision medicine;preclinical study;Prediction of Response to Therapy;premalignant;Process;prognostic;Property;Proteins;quantitative imaging;Regimen;response;response biomarker;Ring Finger Domain;single-cell RNA sequencing;support tools;Survival Rate;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;Tracer;Translations;tumor;tumor microenvironment;ubiquitin-protein ligase

PROJECT_TITLE: Quantitative Imaging of OXPHOS in Pancreatic Cancer


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics Project Narrative  Our laboratory has led three research programs at the interface of chemistry and evolution. We developed an approach to the synthesis and discovery of bioactive small molecules that combines powerful aspects of biological evolution with synthetic organic chemistry; we developed base editing and prime editing, two genome editing technologies that collectively enable introduction of all possible point mutations, insertions, and deletions at targeted DNA sequences in human cells without cutting the DNA double helix; and we have applied these technologies to treat animal models of human genetic diseases by directly correcting the mutations that cause the diseases. This MIRA renewal seeks to advance these three research programs towards novel therapeutics.

PI_NAMEs: LIU, DAVID R (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Animal Model;ATP phosphohydrolase;base editing;Binding;Biological;Biology;cell type;Cells;Chemistry;Chimeric Proteins;chronic pain management;Cyclophilins;Deaminase;Disease;DNA;DNA Double Strand Break;DNA Library;DNA Repair Gene;DNA Sequence;DNA-Binding Proteins;Engineering;Enzymes;Evolution;Genetic;Genetic Diseases;genome editing;Guide RNA;Human;human model;improved;In Vitro;in vivo;inhibitor;Insulin Antagonists;Insulinase;interest;Interleukin Receptor;Interleukins;kinase inhibitor;Laboratories;Libraries;Mammalian Cell;mammalian genome;Methods;mutation correction;novel;novel strategies;novel therapeutics;nucleobase;Organic Chemistry;Phenotype;Physiological;Point Mutation;Polymers;prime editing;prime editor;Progeria;programs;Protease Inhibitor;Research;RNA-Directed DNA Polymerase;Roentgen Rays;Site;small molecule;Spinal Muscular Atrophy;Structure;Syndrome;System;targeted treatment;Technology;therapeutic genome editing;transition mutation;Tumor Suppressor Proteins;ubiquitin isopeptidase;ubiquitin-protein ligase;Variant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Precise control over gene expression programs is critical for cellular differentiation, and when control is lost, outcomes can be tragic, ranging from developmental disorders to cancer. Therefore, understanding how chromatin and epigenetic marks control gene expression will be highly beneficial for preventing and treating diseases in which cellular programming defects are central. This project defines how interplay between chromatin elements and transcription factors regulates gene expression programs and cell-type specification during vertebrate development.

PI_NAMEs: MURPHY, PATRICK J. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Binding;Biological Process;Biology;carcinogenesis;Cell Differentiation process;Cell Reprogramming;cell type;Chromatin;Defect;Development;Developmental Biology;developmental disease;Disease;DNA Binding;DNA Sequence;DNA-Binding Proteins;Elements;Embryo;Embryonic Development;Enhancers;Epigenetic Process;Failure;Gene Expression;Gene Expression Profile;Gene Expression Regulation;genetic manipulation;Genetic Transcription;Genome;genome-wide;Germ Cells;Histone H2A;Histones;in vivo;Link;Location;Malignant Neoplasms;Modeling;next generation;Nucleosomes;Outcome;Pattern;Polymerase;prevent;programs;Role;Series;Specific qualifier value;stem cell function;stem cells;Testing;transcription factor;Transcriptional Activation;Variant;Zebrafish;zebrafish development

PROJECT_TITLE: Function of Chromatin Features in Cellular Programming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Columbus

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Older adults have experienced significant increases in opioid use disorder (OUD) or overdose (OD) in the last decade despite a decrease in the number of opioid prescriptions, dictating a critical need for research to identify factors beyond prescription opioid use that may contribute to the conditions. The proposed research, which is responsive to the Agency for Healthcare Research and Quality’s special interest in research to address substance use disorders, will provide evidence on the associations of poor pain control, multimorbidity, and the interactions of opioids with comorbid drug use with risk for OUD or OD in older adults. Findings from this proposed study will inform interventions to address the dual crises of chronic pain and OUD or OD in older populations.

PI_NAMEs: WEI, YU-JUNG “JENNY”  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Pain, Multimorbidity, Opioid-Drug Interactions and Risk for Opioid Use Disorder or Overdose in Older Adults

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This K01 NCI Mentored Research Scientist Development Award to Promote Diversity proposal will explore epigenetic therapies to activate transposable elements (TEs) to promote neoepitope presentation, and will identify and characterize additional epigenetic mechanisms regulating TE expression to identify potential novel therapeutic targets. The training plan is designed to prepare me for a career in translational cancer research by providing additional coursework in advanced genomics, proteomics, and immunology, training in laboratory management, grant administration, and mentored experiences with my committee of expert mentors.

PI_NAMEs: DE CUBAS, AGUIRRE A (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: anti-cancer;anti-cancer research;anti-CTLA4;anti-PD-L1;Anti-viral Response;Antigen Presentation;Binding;Bioinformatics;Caliber;cancer therapy;career;career development;Cell Line;Cell Physiology;chromatin immunoprecipitation;Clear cell renal cell carcinoma;Clinical;clinical application;Clinical Trials;Computational Biology;Data;Dedications;design;Development;Disease;DNA;DNA Transposable Elements;Doctor of Philosophy;Educational workshop;Elements;Endogenous Retroviruses;Epigenetic Process;epigenetic therapy;Event;evidence base;experience;Faculty;Fluorescence Microscopy;Future;Genetic Transcription;genomic data;Genomics;Goals;Grant;high throughput screening;immune activation;immune cell infiltrate;immune checkpoint blockade;immune clearance;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologics;Immunology;Immunooncology;Immunoprecipitation;Immunosuppression;Immunotherapy;Impotence;in vivo Model;innovation;insight;Institution;Interferon Activation;Interferons;Investigation;knock-down;Laboratories;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Messenger RNA;neoantigens;new therapeutic target;next generation sequencing;novel;novel therapeutic intervention;novel therapeutics;Open Reading Frames;outcome prediction;pathogen;Pathogenicity;Pathway interactions;patient population;Patients;Peptides;Personnel Management;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pheochromocytoma;Positioning Attribute;Postdoctoral Fellow;predicting response;Process;Production;Prognosis;protein aminoacid sequence;Proteins;Proteomics;receptor;Regulation;Relapse;Renal Carcinoma;Renal Cell Carcinoma;Reporter;Reporting;Repression;Research;Research Personnel;research study;Research Training;response;Response Elements;RNA;RNA Splicing;Role;Signal Transduction;Source;success;T-Lymphocyte;TBK1 gene;tenure track;Testing;Therapeutic;Time;Training;Training Activity;Transcript;Transcription Initiation Site;Translating;translational cancer research;tumor;tumor immunology;tumor microenvironment;tumor-immune system interactions;Universities;urologic;Viral

PROJECT_TITLE: Activation of transposable elements as an endogenous source of neoepitopes and mediators of tumor immunogenicity

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative  High blood sugar, cholesterol, and fat increase a person’s risk of developing heart disease. We treat each of these changes individually, which means that our treatments are not as effective as they could be. In this project, we will create a computer program to help us understand how altered blood sugar and fat interact to change the function of our blood vessels and lead to heart disease.

PI_NAMEs: MORSS CLYNE, ALISA S (contact);SRIRAM, GANESH

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;American;Arterial Fatty Streak;Biochemical Pathway;Biomedical Engineering;Blood;Blood Glucose;blood lead;Blood Vessels;Brain;Calcium Signaling;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular disorder therapy;Cell Communication;Cell Membrane Permeability;Cell model;cell type;Cells;Cellular Metabolic Process;Cholesterol;Coculture Techniques;Communities;Complex;Computer Analysis;Computer Models;computer program;Consumption;Data;design;Disease;Drug Interactions;Endothelial Cells;Endothelium;Engineering;Environment;Experimental Models;experimental study;Exposure to;Fatty acid glycerol esters;Fatty Acids;Functional disorder;Glucose;glucose metabolism;glucose uptake;Glutamine;Goals;Growth Factor;Heart Diseases;Human;in silico;In Vitro;in vivo;Individual;Ions;Isotopes;Light;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;Metabolic syndrome;Metabolism;Methods;migration;Modeling;Morbidity - disease rate;mortality;novel;Nutrient;Organism;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Proliferating;Risk;Signal Transduction;Smooth Muscle Myocytes;Testing;therapy design;tissue culture;Tissues;Triglycerides;Tunica Intima;Vascular Endothelial Cell;Vascular Endothelium;Vascular Smooth Muscle

PROJECT_TITLE: Metabolic interactions in the vascular wall: an integrated experimental and computational approach

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Physical Activity;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE: Pulmonary arterial hypertension (PAH) is a debilitating condition that often affects people in the prime of life resulting in right heart failure with severe impairments in quality of life and exercise capacity. In this project, we will directly measure peripheral oxygen (O2) utilization at the skeletal muscle and mitochondrial level during exertion in people with PAH for the first time, and then conduct a randomized clinical trial of leg-muscle focused exercise training to improve muscle O2 utilization and exercise capacity. As a result of this work, we will be able to determine the mechanisms and independent role of skeletal muscle abnormalities in PAH related symptoms, as well as their ability to respond to a novel and easy to implement leg-muscle exercise program.

PI_NAMEs: REDDY, YOGESH NELLORE VILAMBI (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accelerometer;Address;Adopted;Aerobic Exercise;Affect;Aftercare;Age;Award;Biology;Biopsy;Biostatistical Methods;Blood flow;Blood gas;Blood Vessels;Body mass index;Cardiac Output;Cardiovascular Abnormalities;Cardiovascular system;Clinic;Clinical;Clinical Trials;clinically significant;comparison control;Complement;Consumption;Data;Educational Intervention;Exercise;exercise capacity;exercise intolerance;Exercise Physiology;exercise program;Exercise Therapy;Exercise Tolerance;exercise training;Exertion;exhaustion;experience;Extensor;Femur;fitbit;Functional disorder;Funding;Goals;Grant;Heart;Heart failure;Heart Rate;hemodynamics;Impairment;improved;indexing;Individual;Intervention;K-Series Research Career Programs;Knee;Knowledge;Left;Leg;Life;Lung;Magnetic Resonance Imaging;mathematical model;Measurement;Measures;Medicine;Mentors;Mentorship;Methods;Mitochondria;Monitor;multidisciplinary;Muscle;muscle form;Muscle Mitochondria;novel;Outcome;Oxidative Stress;Oxygen;Participant;Patient Care;Patient Outcomes Assessments;Patients;Performance;Peripheral;Persons;Physiology;Positioning Attribute;primary endpoint;Production;professor;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;quadriceps muscle;Quality of life;Questionnaires;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research Personnel;Residual state;Respiration;right ventricular failure;Role;Scientist;sedentary;sex;Skeletal Muscle;skills;standard of care;Supination;Surveys;Symptoms;targeted treatment;Techniques;Therapeutic;Thermodilution;Time;time use;Training;translational clinical trial;United States National Institutes of Health;Vasodilator Agents;Walking;wearable device;week trial;Woman;Work

PROJECT_TITLE: Peripheral Limitations in Pulmonary Hypertension and Effects of Muscle Training

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Prevention

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Narrative Mutations in human genes encoding DDX3 and its downstream targets cause common birth defects that likely derive from impaired development of the neural crest stem cells, but little is known about the underlying mechanisms. This proposed work aims to address this problem by elucidating the roles of these genes and their relationship with each other in the formation of neural crest under normal and pathological conditions.

PI_NAMEs: WEI, SHUO  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Affect;beta catenin;Biological Markers;Clinical;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial disorder;craniofacial structure;craniofacial tissue;CTNNB1 gene;Data;de novo mutation;Dental;Development;Diagnosis;diagnostic tool;Disease;Embryonic Development;Etiology;expectation;feasibility testing;Functional disorder;gene function;gene regulatory network;Genes;glycogen synthase kinase 3 beta;Goals;Human;human model;Impairment;insight;Intellectual functioning disability;Knock-in;Knowledge;Lead;Mediating;Methods;Modeling;Monomeric GTP-Binding Proteins;Morphogenesis;Multipotent Stem Cells;mutant;Mutation;Neural Crest;Neural Crest Cell;neural plate;neurodevelopment;neuromechanism;neuroregulation;novel;novel diagnostics;Outcome;Pathologic;Pathway interactions;Peripheral Nervous System;Phosphorylation;Phosphotransferases;precise genome editing;prevent;Prevention;Prevention strategy;Proto-Oncogene Proteins c-akt;Research;RNA Helicase;Role;Signal Transduction;Signaling Molecule;stem cells;Study models;Testing;Tissues;tool;transcription factor;WNT Signaling Pathway;Work;Xenopus

PROJECT_TITLE: Mechanisms of Neural Crest Induction and Craniofacial Disorders

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: FOUNDATION FOR AIDS RESEARCH

PHR: PROJECT NARRATIVE IeDEA Asia-Pacific will study the effects of HIV, co-infections, and co-morbidities on long-term HIV treatment outcomes in order to inform clinical practice and public health policy in the region. Research also will assess strategies to improve HIV-related treatment and prevention service delivery for high-risk and vulnerable populations. Data from the research program will guide efforts to achieve and sustain long-lasting health gains for people living with and at risk of HIV in the Asia-Pacific.

PI_NAMEs: LAW, MATTHEW ;PETOUMENOS, KATHY ;SOHN, ANNETTE H (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adult;Age;Aging;Alcohol consumption;antiretroviral therapy;Asia;Behavior;Behavior assessment;Cambodia;Cardiovascular Diseases;Caring;Child;Chronic Hepatitis B;clinical care;clinical center;clinical practice;Clinical Research;co-infection;cohort;Cohort Analysis;Collaborations;Communities;comorbidity;Complex;Comprehensive Health Care;Continuity of Patient Care;Country;COVID-19;Data;Data Analyses;Data Collection;data harmonization;data registry;Data Sources;Databases;diagnostic technologies;Disease;Disease Progression;epidemic response;Equilibrium;Exposure to;Failure;Family Research;Goals;Grant;Health;Health Policy;Health Resources;Health system;Hepatitis C;High Prevalence;high risk;high risk population;HIV;implementation strategy;improved;Individual;Infection;innovation;Intervention;Leadership;Life Cycle Stages;Longitudinal cohort study;Malignant neoplasm of anus;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Mental Health;Mental Health Services;Mentorship;mortality;next generation;novel;Outcome;Persons;physical conditioning;Policy Maker;Population;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention approach;prevention service;Preventive therapy;Productivity;programs;Public Health;Publications;Quality of life;Registries;Research;Research Methodology;Research Personnel;Resources;Risk;Screening for cancer;Secure;service delivery;skills;substance use;Thailand;Tobacco;Training;Training Activity;transgender;Treatment outcome;treatment services;Tuberculosis;uptake;Viral;Virus;Vulnerable Populations;Work;young men who have sex with men;Youth

PROJECT_TITLE: IeDEA Asia-Pacific Research Collaboration


NIH_SPENDING_CATS: Genetics;Natural Products

ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: The discovery of ligandable RNA-protein interactions is vital for deciphering the cellular functions and molecular mechanisms of regulatory RNAs that act through the formation of dynamic ribonucleoprotein complexes, but remains a formidable challenge. This proposal aims to exploit reactivity of proteinaceous lysines at RNA-protein interaction interface by leveraging quantitative chemoproteomic technology and heretofore unknown mechanism of action exerted by phloroglucinol meroterpenoid natural products. The success of the proposed research will deliver innovative chemical tools and proteomic methods that enrich our understanding of the pathophysiological functions of RNA-protein interactions and identify the basis for their therapeutic effects in human diseases.

PI_NAMEs: ABBASOV, MIKAIL E (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Autoimmunity;Biochemistry;Cell Physiology;Cells;Chemicals;chemoproteomics;Code;Complement;Complex;Defect;Development;drug discovery;Drug Targeting;Epitopes;Gene Expression;Goals;Human;human disease;Image;Immune response;Immunofluorescence Immunologic;innovation;Lysine;Malignant Neoplasms;Maps;Methods;Modification;Molecular;Molecular Biology;National Institute of General Medical Sciences;Natural Products;Nerve Degeneration;Phloroglucinol;Physiology;programs;Property;protein function;Proteomics;Research;Ribonucleoproteins;RNA;RNA Binding;RNA-Binding Proteins;RNA-Protein Interaction;Role;Site;Specificity;success;Technology;Therapeutic;Therapeutic Agents;therapeutic candidate;Therapeutic Effect;tool;Transcript;Untranslated RNA;Viral

PROJECT_TITLE: Chemoproteomic mapping of the ligandable ribonucleoproteome using phloroglucinol meroterpenoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Baylor College of Medicine, in collaboration with the University of Texas School of Public Health, the University of Eswatini, and the Eswatini Ministry of Health (including national HIV and Tuberculosis programs) will conduct training in HIV/AIDS research methods with a focus on pediatrics (infants, children, adolescents) and tuberculosis co-morbidity. Leveraging dual Emaswati-US mentor teams, we will conduct long-term US based and in-country research training in four essential programmatic areas including epidemiology, biostatistics and bio-informatics, behavioral science and health promotion, and health systems management and policy. Our goal is to strengthen clinical and translational research capacity in Eswatini while simultaneously producing high-quality researchers who will successfully transition to independent funding and lead national efforts to end the HIV/TB co-pandemics.

PI_NAMEs: MANDALAKAS, ANNA M (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adolescent;Affect;Applied Research;Area;Back;behavioral health;Behavioral Sciences;Bioinformatics;Biometry;Child;Child Health;Childhood;Clinical Research;cohort;Collaborations;college;Communities;comorbidity;Country;Doctor of Philosophy;education research;Educational process of instructing;Enrollment;Ensure;environmental enrichment for laboratory animals;Epidemic;Epidemiology;Fogarty International Center;Funding;Future;Goals;Health;Health Professional;Health Promotion;Health system;HIV;HIV/AIDS;HIV/TB;Infant;Institution;Investigation;Knowledge;Lead;Medicine;Mentors;mortality;multidisciplinary;next generation;novel;pediatric human immunodeficiency virus;Pediatrics;Policies;Population;programs;Public Health;Public Health Schools;Qualifying;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Scientist;skills;success;Texas;Training;Training Programs;Translational Research;Tuberculosis;United States National Institutes of Health;Universities

PROJECT_TITLE: Siyakhula: Growing HIV/TB Research Knowledge for Growing Healthy Kids in Eswatini


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Neonatal hypoxic ischemic encephalopathy (HIE) is an injury to the developing brain that accounts for millions of years lived with disability worldwide and can be modeled in mice by transient late gestation prenatal hypoxia. Epigenetic modifying genes, like the histone variant H3f3b, are upregulated in the corticothalamic neurons of mice exposed to prenatal hypoxia. To gain insight into how epigenetic regulators may modulate outcomes after hypoxic insult, I will test if H3f3b protects developing neurons from more severe injury after prenatal hypoxia and if prenatal hypoxia persistently disrupts the epigenetic trajectories of corticothalamic neurons.

PI_NAMEs: CRISTANCHO, ANA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Adult;Affect;Animals;Anterior;Anxiety;ATAC-seq;Automobile Driving;Axon;Behavior;Behavioral;Bioinformatics;Biological;Birth;Brain;Brain Injuries;career;CASP3 gene;Cell Death;Cell Nucleus;cell type;Cells;Child;Chromatin;cingulate cortex;Clinical;Clinical Skills;conditional knockout;Data;Dendritic Spines;density;Development;differential expression;Disease;Doctor of Philosophy;Electroporation;Embryo;Environment;Epigenetic Process;epigenetic regulation;epigenome;experience;Exposure to;fetal;Functional disorder;Funding;Gene Combinations;gene environment interaction;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Golgi Apparatus;High-Throughput Nucleotide Sequencing;Histones;Hour;Human;Hypoxia;Hypoxic Brain Damage;Image;improved;improved outcome;In Situ Nick-End Labeling;in utero;Incidence;Injury;insight;Knockout Mice;Lead;Learning;Link;mature animal;Measures;Mentored Clinical Scientist Development Program;Mentors;Modeling;Molecular;Molecular Biology;Motor;mouse model;Mus;Neocortex;Neonatal;neonatal hypoxic-ischemic brain injury;Nervous System Disorder;Neurodevelopmental Disability;Neurologic Deficit;Neurological outcome;Neurologist;Neuronal Injury;Neurons;novel;Nutrient;Ontology;Outcome;overexpression;Oxygen;Pathogenicity;Pathology;Pathway interactions;Perinatal;Perinatal Brain Injury;Perinatal Care;perinatal injury;Pharmaceutical Preparations;Phenocopy;Phenotype;Physicians;Play;postnatal;preclinical study;Pregnancy;prenatal;Prenatal Injuries;prevent;Prosencephalon;Research;Research Personnel;resilience;response;RNA;Role;Scientist;Seizures;severe injury;Severities;single nucleus RNA-sequencing;skills;Small Nuclear RNA;social skills;Stains;Stress;Structure;targeted treatment;tenure track;Testing;Therapeutic;therapeutic target;Training;Transcriptional Regulation;transcriptome;Translating;Translational Research;Up-Regulation;Variant;Vertebral column;years lived with disability

PROJECT_TITLE: Interrogation and Modulation of the Epigenome after Prenatal Hypoxic Brain Injury


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Nutrition;Pediatric;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Phenylketonuria (PKU) is an inborn metabolic disorder caused by a metabolic deficiency in the hydrolysis of phenylalanine to Tyrosine, and the only currently available treatment options for this disease are largely focused on dietary management and supplementation of missing enzymatic components. The prevailing view of this disorder is primarily concerned with mutations in the gene coding for the enzyme responsible for this metabolic process, phenylalanine hydroxylase (PAH), but fails to acknowledge the functional role of long noncoding RNAs (lncRNAs) in this inborn metabolic disorder. Based on genetic evidence that mutations of the lncRNA HULC and mouse lncRNA Pair lead to PAH enzymatic deficiencies, potential treatment strategy utilizing specially designed HULC mimics might restore the enzymatic activity of the 11 PAH mutations most commonly attributed to PKU, thereby demonstrating the biological importance of lncRNA-mediated molecular events in human genetic disorders.

PI_NAMEs: SUTTON, VERNON R;YANG, LIUQING  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Agonist;Alleles;Animals;antagonist;Biological;Biological Markers;Blood;Categories;Chromatin;Classical phenylketonuria;Clinical;Code;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;design;Development;Diet;dietary;Disease;DNA Sequence Alteration;Enhancers;Enzyme Interaction;Enzymes;Event;Female;Foundations;Frequencies;frontier;Future;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;Goals;Growth;Hepatocyte;Hereditary Disease;Human;Human Genetics;human model;Hydrolysis;Hypopigmentation;Impairment;improved;Indole-3-Carbinol;induced pluripotent stem cell;Inherited;inhibitor;innovation;insight;Knock-out;Lead;Liver;Lymphokine-Activated Killer Cells;male;Mediating;Medical Research;Medicine;Mental Retardation;Metabolic;Metabolic Diseases;Metabolism;Molecular;mouse model;Mus;mutant;Mutation;Neurologic Symptoms;Neurons;Odors;Oligonucleotides;Outcome;Pathologic;Patients;Peptides;Phenylalanine;Phenylalanine Hydroxylase;Phenylketonurias;Phosphorylation;Physiological;Plasma;Polyubiquitination;Post-Translational Protein Processing;precision medicine;Process;protein degradation;Protein Kinase;Proteins;Publishing;Regulation;Research;RNA;Role;Science;Seizures;Serum;Severities;Signal Transduction;small molecule;small molecule inhibitor;Supplementation;Symptoms;System;targeted treatment;Therapeutic;therapeutic RNA;treatment strategy;Tyrosine;ubiquitin-protein ligase;Untranslated RNA;Variant;Work

PROJECT_TITLE: Molecular Mechanism of long Noncoding RNAs in Phenylketonuria

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Every year more than 795,000 people in the United States have a stroke with currently around 4.7 million stroke survivors, and approximately 20% of the survivors go on to develop cognitive impairments and dementia later in life. This research project will seek an improved basic scientific understanding of the how the complex biological interactions between vascular and demographic risk factors (e.g., disadvantaged neighborhoods), baseline brain and cognitive health, and adaptive or maladaptive brain changes following an ischemic stroke, underlie the biology of vascular contributions to cognitive impairments and dementia (VCID). It will also seek development of diagnostic and prognostic tools based on non-invasive high-quality MRI biomarkers which may aid in positively altering disease progression and reducing the burden of illness on patients due to post ischemic stroke VCID.

PI_NAMEs: ADLURU, NAGESH ;NAIR, VEENA A (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: accurate diagnosis;Affect;African American population;Alzheimer's Disease;Amyloid;Atlases;Attention;Biological;Biological Markers;Biology;Blood Vessels;Brain;brain health;burden of illness;Cardiovascular system;Categories;cerebral atrophy;Chronic;Clinical;clinical care;Clinical Research;Cognition;Cognitive;Complex;connectome;Data;Dementia;dementia risk;demographics;Development;Diagnosis;diagnostic development;diagnostic tool;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Distal;executive function;Foundations;Functional Magnetic Resonance Imaging;Future;Health;Hemorrhage;Hispanic Populations;hypoperfusion;Image;Impaired cognition;Impairment;improved;innovation;Ischemic Stroke;Language;Left;Lesion;Life;Location;Machine Learning;machine learning method;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Mediating;Memory;Microvascular Dysfunction;middle cerebral artery;Minority Groups;Modeling;Monitor;Native Americans;neighborhood disadvantage;neural network;Neuropsychology;Neurosciences;novel;Outcome;Pathway interactions;Patient Recruitments;Patients;Pattern;Perfusion;Persons;post stroke;predictive modeling;Predisposition;Prognosis;prognostic tool;prognostication;prospective;Prospective cohort;Research;Research Project Grants;Rest;Risk;Risk Assessment;Risk Factors;Rural;socioeconomic disadvantage;standard of care;Stroke;stroke cognitive outcome;stroke patient;stroke survivor;Structure;Survivors;tool;Underrepresented Minority;United States;Validation;vascular cognitive impairment and dementia;Visuospatial;white matter;White Matter Hyperintensity

PROJECT_TITLE: Stroke Connectome MRI Biomarkers for VCID Risk Assessment

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Patient Safety

ORG_CITY: LUBBOCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: NARRATIVE P-glycoprotein is the cell's cleaning machine, pumping harmful substances to the outside of the cell. It is among the seven most important transporters responsible for regulating drug absorption and disposition that now require documentation of drug interactions for approval of any new drugs by the US Food and Drug Administration (FDA). By learning more about how P-glycoprotein recognizes the chemicals that it carries out of the cell, scientists may redesign drugs to prevent P-glycoprotein from interfering with their valuable effects in the treatment of many diseases.

PI_NAMEs: URBATSCH, INA L (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: ABCB1 gene;absorption;Acceleration;Affinity;Amber;Amino Acids;Antineoplastic Agents;Area;Aromatic Amino Acids;ATP Hydrolysis;ATP-Binding Cassette Transporters;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Availability;Biomedical Engineering;biophysical techniques;Blood - brain barrier anatomy;cancer drug resistance;cancer therapy;Cardiovascular Agents;Cardiovascular system;Cell membrane;Cells;Chemicals;Clinical;clinically relevant;Codon Nucleotides;combat;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Tail;Development;Dimerization;Disease;Documentation;Drug Binding Site;Drug Combinations;Drug Design;Drug Efflux;Drug Interactions;Drug Kinetics;Drug Metabolic Detoxication;Drug Monitoring;Drug resistance;Drug Transport;Drug usage;efflux pump;Energy Transfer;Engineering;Environment;Excretory function;experience;experimental study;Fluorescence;Fluorescence Spectroscopy;Fluorescent Probes;functional group;Goals;HIV/AIDS;Human;Hydrophobicity;inhibitor;insight;Intestines;Kidney;Kinetics;Knowledge;Laboratories;Learning;Ligand Binding;Lipid Bilayers;Liver;Maps;Measures;Membrane;Mental disorders;Molecular;Molecular Conformation;molecular pump;Monitor;Multi-Drug Resistance;nanodisk;Nifedipine;novel strategies;novel therapeutics;Nucleotides;Paclitaxel;Pharmaceutical Preparations;Positioning Attribute;Prazosin;prevent;Property;protein purification;protein reconstitution;Pump;rational design;Recombinant Proteins;reconstitution;Rhodamine 123;Roentgen Rays;Scientist;Screening procedure;single molecule;Site;Structure;success;Surface;System;Technology;Terminator Codon;Tertiary Protein Structure;Testing;Therapeutic;tool;Toxin;Transmembrane Domain;Tryptophan;tryptophan analog;United States Food and Drug Administration;uptake;Variant;Vinblastine;X-Ray Crystallography

PROJECT_TITLE: Studies of P-glycoprotein drug interactions

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE We are developing a novel technology for indefinitely preserving donor kidneys for transplant in an extremely low-temperature, vitrified (glass-like) state and subsequently rewarming them on-demand using nanotechnology. This method for cryopreserving or “banking” kidneys prior to transplant will allow a new paradigm for transplantation that improves donor/recipient matching, allows for better patient preparation, facilitates tolerance induction protocols, and increases organ utilization; all while improving kidney durability and patient survival.

PI_NAMEs: BISCHOF, JOHN C;FINGER, ERIK BRIAN (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Affect;allotransplant;Animal Model;Architecture;Benchmarking;Biocompatible Materials;Biological;Blood Vessels;Body System;CCR;Chronic Kidney Failure;clinical translation;cold temperature;comparison control;Compensation;cost;Cryopreservation;Cryoprotective Agents;Crystallization;Data;Dialysis procedure;Endothelium;Engineering;Family suidae;Funding;Glass;Goals;Healthcare;Heart;Heating;Human;Ice;Immune response;implantation;improved;In Vitro;in vivo;Injury;iron oxide nanoparticle;Ischemia;ischemic injury;Kidney;Kidney Transplantation;Life Expectancy;Liquid substance;Liver;magnetic field;Measures;Methods;Modeling;Molecular;nanoparticle;Nanotechnology;nanowarming;new technology;novel;novel strategies;Organ;Organ Donor;Organ Preservation;Organ Size;Organ Transplantation;Oryctolagus cuniculus;Patients;Performance;Perfusion;PF4 Gene;Phase Transition;Population;Preparation;preservation;pressure;Progressive Disease;Protocols documentation;Quality of life;radio frequency;Rattus;Recovery;Renal function;Reperfusion Therapy;Reproducibility;response to injury;Rewarming;RF coil;Rodent;scale up;Solid;Speed;success;supply chain;System;Technology;Temperature;Testing;thermal stress;Time;Tissue Viability;Tissues;transplant model;Transplantation;Transplantation Tolerance;vitreous state

PROJECT_TITLE: Organ banking for transplant--kidney cryopreservation by vitrification and novel nanowarming technology

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Infectious diseases caused by bacterial pathogens are a major concern of public health. Our study on the exploitation of the host ubiquitin system by L. pneumophila will provide not only novel strategies for prevention and/or treatment of infections caused by this pathogen, but also new knowledge in cell signaling for better understanding of development and disease processes.

PI_NAMEs: LUO, ZHAO-QING  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;ADP ribosylation;Affect;Bacteria;Biochemical;Biogenesis;Bioinformatics;Biology;Biotin;Calmodulin;Catalysis;Cell Physiology;Cells;Communicable Diseases;Coupled;Cytosol;Development;Diagnosis;Disease;Energy-Generating Resources;Enzymes;Experimental Designs;experimental study;F Box Domain;Family;Funding;Genes;Goals;Growth;Immunity;Infection;insight;Knowledge;Label;Legionella;Legionella pneumophila;Ligase;Mediating;member;Membrane;Membrane Fusion;Methods;Modeling;Modification;Molecular;Mono(ADP-Ribose) Transferases;mutant;novel;novel diagnostics;novel strategies;novel therapeutic intervention;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;permissiveness;Phagocytes;Phagosomes;phosphoric diester hydrolase;Prevention strategy;Process;programs;protein function;Protein Secretion;Proteins;Public Health;Reaction;recruit;Regulation;Research;Role;Serine;Side;Signal Transduction;Signaling Molecule;SNAP receptor;Structure;System;target SNARE proteins;Testing;trafficking;Transglutaminases;Type IV Secretion System Pathway;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;vesicular SNARE proteins;virtual;Virulence

PROJECT_TITLE: Effector-mediated ubiquitin manipulation in Legionella pneumophila pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative The purpose of this proposal is to characterize genetic and environmental factors that synergistically interact to cause head and face birth defects. The results obtained will greatly increase our understanding of the multifactorial basis of craniofacial birth defects in humans.

PI_NAMEs: EVERSON, JOSHUA L (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Affect;alcohol response;Alcohols;Animals;Bioinformatics;Biological Models;Brain;Chemicals;Communication;comparative;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;CRISPR/Cas technology;Critical Pathways;Data;Defect;Development;developmental toxicology;Disease;Dizziness;DNA Sequence Alteration;Dysmorphology;Embryo;Environment;environmental chemical;Environmental Exposure;Environmental Risk Factor;Erinaceidae;Ethanol;Etiology;Face;gene environment interaction;gene network;gene regulatory network;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;Genetic Variation;Growth;Head;high throughput analysis;Human;human disease;insight;Logic;Modeling;Modernization;Molecular;Morphogenesis;Mus;Mutation;Nature;novel;Palate;Pathway interactions;prevent;Prevention;Process;Reader;Risk;SHH gene;Signal Pathway;Signal Transduction;smoothened signaling pathway;Sonic Hedgehog Pathway;teratogenesis;Testing;Toxic effect;Toxic Environmental Substances;toxicant;Toxicogenomics;transcriptome;transcriptomics;Validation;Zebrafish

PROJECT_TITLE: Comparative toxicogenomics to determine conserved genetic and environmental interactions in craniofacial birth defects


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Gene-diet interaction analysis seeks to understand how each person’s response to diet is dependent on their genetic makeup. This project is a combined research and training program that combines new statistical methods and data types to better identify these interactions, focusing on the Mediterranean-style diet pattern and its impact on the risk of metabolic diseases like type 2 diabetes. Its results will help researchers, by validating improved scientific methods, and clinicians, by providing a foundation for genome-guided dietary recommendations to prevent metabolic disease.

PI_NAMEs: WESTERMAN, KENNETH E (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affect;Alleles;analytical method;Area;Awareness;Behavior;biobank;career;catalyst;cohort;Complement;Consumption;Data;Data Analyses;Data Reporting;Detection;Development;Diabetes Mellitus;diabetes risk;Diet;dietary;Dietary Assessment;Dietary Factors;Dietary Fats;Dietary Practices;disorder risk;Doctor of Philosophy;experience;fasting glucose;Fellowship;Foundations;Future;Genes;Genetic;Genetic Carriers;genetic makeup;genetic variant;Genome;genome sequencing;genome-wide;Grant;improved;Individual;Intake;inter-individual variation;Leadership;Life Style;Link;Literature;Measurement;Mentors;Mentorship;Metabolic;Metabolic Diseases;metabolomics;Methods;Modeling;Modification;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;nutritional epidemiology;nutritional genomics;Nutritional Study;Outcome;Output;Patient Self-Report;Pattern;Performance;Persons;polygenic risk score;Population Heterogeneity;Positioning Attribute;precision nutrition;prediction algorithm;prevent;Principal Investigator;Proxy;Publications;rare variant;Recommendation;Reporting;Reproducibility;Research;Research Personnel;response;Risk;Risk Factors;Scientist;Scoring Method;Serum;simulation;skills;Statistical Methods;statistics;Strategic Planning;success;TCF7L2 gene;Techniques;Testing;tool;Training;Training Programs;trait;Trans-Omics for Precision Medicine;United States National Institutes of Health;Variant;waist circumference;whole genome;Work

PROJECT_TITLE: Improved detection of gene-diet interactions via longitudinal data, metabolomic proxies, and polygenic scores

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE We aim to develop robust analytical technologies that can provide structural information for biologically important proteins and molecular machines, such as those involved in neurodegenerative disorders and aging (e.g., Alzheimer’s disease). New methodologies to elucidate the sites of protein modifications will be developed, with the knowledge gained on modification sites to be used to enhance our understanding of the cellular mechanisms for a range of biological processes, including Alzheimer's disease. This is a particularly pressing goal in view of the rapid aging of our nation’s population and the rising costs of care for patients with neurodegenerative diseases.

PI_NAMEs: LOO, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Aging;Alzheimer's Disease;Binding;Biological;Biological Process;Biology;biophysical techniques;care costs;Cell Physiology;Complex;Coupling;Disease;Dissociation;drug development;drug discovery;Electrons;Environment;G-Protein-Coupled Receptors;Gases;Goals;Higher Order Chromatin Structure;improved;insight;ionization;Knowledge;Ligands;Link;Mass Spectrum Analysis;Measures;Membrane Proteins;Methodology;Methods;Modification;Molecular Machines;Neurodegenerative Disorders;Pathway interactions;Patient Care;Phase;Population;Post-Translational Protein Processing;preservation;Protein Analysis;Proteins;Proteomics;Regulation;Resolution;Site;structural biology;Structure;Techniques;Technology;tool;Toxic effect;ultra high resolution

PROJECT_TITLE: Advancing Mass Spectrometry Analyses of Proteins, Assemblies, and Proteoforms

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Adolescent suicide is a major public health crisis, with evidence of increasing rates in youth across the past decade, but we lack robust predictors of future suicidal behavior. We will examine neural measures of reward valuation as prospective predictors of suicidal behavior and responses to interpersonal stress in a large high- risk sample of adolescents followed for 6 months after acute psychiatric treatment. This study will advance understanding of pathways to suicidal behavior in adolescents and inform methods of identifying adolescents most in need of immediate intervention to prevent suicide.

PI_NAMEs: KUJAWA, AUTUMN J (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 17 year old;Acute;Address;Admission activity;Adolescent;adolescent suicide;Age;Behavior;behavior measurement;Behavioral;behavioral outcome;biomarker identification;brain based;Buffers;Cause of Death;Clinical assessments;Communication;Complex;cost effective;Data;Development;Diagnostic;direct application;Disclosure;discounting;Economic Burden;Electroencephalography;Emotional;Exhibits;Feeling suicidal;follow-up;Frequencies;Future;Goals;Health;high risk;high-risk adolescents;Hospitals;Hour;Individual Differences;innovation;insight;Interruption;Intervention;Interview;life span;Link;Literature;Measures;Mental Depression;Methods;Modeling;National Institute of Mental Health;neural;neural circuit;neuroimaging;novel;Pain;Participant;Pathway interactions;Patient Self-Report;Patients;Pattern;pleasure;Positive Valence;precision medicine;Predictive Factor;Predisposition;preference;Process;prospective;Prospective Studies;prospective test;psychiatric symptom;Psychiatric therapeutic procedure;Psychological reinforcement;Psychopathology;Public Health;Recording of previous events;recruit;reinforcer;Research;Research Domain Criteria;Research Priority;response;reward processing;Rewards;Risk;Risk Behaviors;Risk Factors;Sampling;social;Social Environment;Social support;Stress;stressor;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Surveys;System;Techniques;Telephone;Testing;theories;Thinking;Time;Youth

PROJECT_TITLE: Reward Valuation and Suicidal Behavior in High-Risk Adolescents

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Patients who are at high-risk for developing ovarian cancer have limited options to lower their risk without enduring surgical menopause and multiple unfavorable health-related outcomes. Atovaquone, an orally available anti-malarial medication, blocks oxidative phosphorylation by interfering with mitochondrial electron transport and slows ovarian cancer growth in vitro and in vivo. It has the potential to prevent cancerous transformation in the ovaries and fallopian tubes of high-risk women, eliminating the need for premature removal of their gynecologic structures.

PI_NAMEs: BARROILHET, LISA M (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Address;aerobic glycolysis;Algorithms;Anti-malarials;Antioxidants;Apoptosis;atovaquone;Benign;Binding Sites;Biological Markers;biomarker evaluation;bone health;BRCA1 gene;BRCA2 gene;Breast Cancer Risk Factor;cancer cell;Cancer cell line;cancer risk;Cancerous;Carcinoma;cardiovascular health;catalase;Chemoprevention;Chemopreventive Agent;Chemoresistance;Clinical Trials;cohort;Collecting Cell;comparative;Contraceptive Usage;Control Animal;Credentialing;Cytochromes b;Cytology;cytotoxicity;Data;Deterioration;Development;Disease;Dose;Early Diagnosis;early phase clinical trial;efficacy evaluation;efficacy study;Electron Transport;Electron Transport Complex III;Eligibility Determination;Enterobacteria phage P1 Cre recombinase;Epithelium;Evaluation;Excision;exposed human population;Exposure to;FDA approved;Future;Genes;Genetically Engineered Mouse;Germ-Line Mutation;Goals;Growth;Gynecologic;Gynecologic Surgical Procedures;Health;high risk;high risk population;High Risk Woman;Human;human disease;Hysteroscopy;In Vitro;in vivo;inducible Cre;inhibitor;innovation;interest;Laboratories;lead candidate;Lesion;lifetime risk;Malaria;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Measures;Mediating;Methods;Mitochondria;mouse model;multidisciplinary;Mus;Neurologic;novel;Operative Surgical Procedures;Oral;Oral Contraceptives;Outcome;Ovarian;Ovary;Oxidative Phosphorylation;Oxidative Stress;Participant;Patient Triage;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Placebo Control;pre-clinical;preclinical development;premature;Premature Menopause;prevent;Prevention;Prevention approach;Prevention strategy;prospective;Proteins;randomized, clinical trials;reproductive;Resistance;resistance mechanism;Resources;response;Risk;Risk Reduction;Role;Sampling;Schedule;screening;Screening for Ovarian Cancer;Serous;Signal Transduction;Specimen;Structure;success;Superoxide Dismutase;surgical menopause;Surrogate Endpoint;Survival Rate;System;Tamoxifen;Testing;Time;Tissues;TP53 gene;transcriptome;Tube;tumor;Tumor Suppressor Genes;Ubiquinone;Variant;Woman;Work;Xenograft procedure

PROJECT_TITLE: Repurposing Atovaquone for Preventing Ovarian Cancer: An Example of Successful Inhibition of Oxidative Phosphorylation

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Neovascular age-related macular degeneration is a leading cause of blindness worldwide. Current treatments to inhibit angiogenesis are effective in less than 50% of patients in part due to the development of macular fibrosis. We use novel approaches to understand the causes of fibrosis and test potential therapies to prevent it.

PI_NAMEs: HARTNETT, MARY ELIZABETH RUTH (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 7-ketocholesterol;Adaptor Signaling Protein;Age;age effect;Angiogenesis Inhibition;Angiogenic Factor;Atrophic;bevacizumab;Blindness;Blood;Bruch's basal membrane structure;cell motility;cell type;Cells;Choroidal Neovascularization;Coculture Techniques;Complex;CRISPR/Cas technology;Cytoplasm;Data;Development;Endothelial Cells;Endothelium;Event;Exposure to;Exudative age-related macular degeneration;Eye;Fibrosis;Flow Cytometry;Functional disorder;Funding;Future;Gene Mutation;Genetic Predisposition to Disease;Genetic Transcription;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;High-Throughput RNA Sequencing;Homeostasis;Human;improved outcome;Inflammatory;inhibitor;Injury;intravitreal injection;KDR gene;Knockout Mice;Knowledge;Label;Lasers;Lesion;macula;Mediating;Mesenchymal;migration;Modeling;Muller's cell;Mus;mutant;NADPH Oxidase;neovascularization;novel;novel strategies;Optical Coherence Tomography;Pathologic;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Physiological;prevent;Proteins;receptor;Reporter;Research;Role;Scaffolding Protein;Serine;Signal Pathway;Signal Transduction;standard care;Stress;Testing;tool;Transforming Growth Factor beta;Vascular Endothelial Growth Factors

PROJECT_TITLE: Endothelial Transmigration in Neovascular Age-related Macular Degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE (RELEVANCE) Severe malaria due to Plasmodium falciparum kills over a million people a year. Resistance to existing antimalarial drugs has created an urgent need for new drugs. Ongoing antimalarial drug development depends on improving our understanding of the basic biology of this pathogen. Our proposal investigates uses antimalarials to investigate the biology of an essential metabolic pathway, the MEP pathway, and will further our understanding of how antimalarial susceptibility is mediated by the HAD family of parasite proteins.

PI_NAMEs: ODOM JOHN, AUDREY RAGAN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: alpha-glycerophosphoric acid;Anabolism;Anopheles Genus;Anti-malarials;asexual;Biochemical;Biological Process;Biology;Carbon;Cessation of life;Chemicals;clinical development;Culicidae;Data;Dedications;Development;drug development;Drug resistance;drug sensitivity;Drug Targeting;Enzymes;Eubacterium;Family;fitness;fosmidomycin;Genes;Genetic;Genetic Markers;Genetic Screening;Genetic study;global health;Glycerol;Glycerol-3-Phosphate Dehydrogenase;Glycolysis;Goals;Homeostasis;Homologous Gene;Human;humanized mouse;improved;in vivo;Infection;inhibitor;innovation;inorganic phosphate;Investigation;isoprenoid;Label;Life;Life Cycle Stages;Liver;Malaria;Mediating;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Molecular;next generation sequencing;novel therapeutics;Organism;Orthologous Gene;Parasite resistance;Parasites;pathogen;Pathway interactions;Persons;Phosphoric Monoester Hydrolases;Plants;Plasmodium falciparum;Predisposition;Protein Dephosphorylation;Proteins;Regulation;Resistance;resistance mechanism;resistance mutation;Role;Source;Stress;tool;transmission process

PROJECT_TITLE: MEP pathway resistance in Plasmodium falciparum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(02)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: People with HIV who are treated with antiretroviral therapy suffer from increased heart disease. We will study specific molecules, namely eicosanoids, to find out if they are involved in the pathway by which persistent inflammation due to HIV infection may lead to heart disease.

PI_NAMEs: MARTINEZ, CLAUDIA  (contact);PETER, INGA

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Address;adjudication;Affect;Age;Anti-Inflammatory Agents;antiretroviral therapy;Attenuated;Automobile Driving;Bioinformatics;Biological;Biological Markers;Biology;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;CD4 Lymphocyte Count;cell regeneration;Chronic;Clinical;clinical predictors;clinically relevant;cohort;Complex;Data;Development;Drug Targeting;Dyslipidemias;Eicosanoid Production;Eicosanoids;Etiology;Event;Exposure to;fatty acid metabolism;Female;Fever;Future;Gene Expression;General Population;genetic predictors;genetic variant;genomic data;genomic locus;Genomics;Heart Diseases;HIV;HIV Infections;illness length;immune activation;Immune response;Immune system;immunoregulation;improved;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;insight;Intervention;Link;lipidomics;Lipids;Machine Learning;Mass Spectrum Analysis;Measures;men;Mendelian randomization;metabolomics;microbial;multidisciplinary;Multiomic Data;multiple omics;Non-Steroidal Anti-Inflammatory Agents;novel;Pain;Participant;Pathogenesis;Pathway interactions;Persons;Pharmacology;Plasma;Polyunsaturated Fatty Acids;Process;Proteomics;Regimen;Reporting;Risk Factors;risk prediction;Role;sex;Sex Differences;sexual dimorphism;stroke risk;System;targeted treatment;Therapeutic;therapeutic target;Thrombosis;Time;Vascular Diseases;Viral;Viral Load result;Virus Diseases;virus identification;Woman

PROJECT_TITLE: The study of Eicosanoids as Novel Inflammatory Mediators of CVD in Men and Women with HIV

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE As the state-of-the-art method to assess consumers’ preferences for new products, discrete choice experiments (DCEs) have been increasingly applied to study the impacts of potential policies on tobacco use behaviors, particularly in the areas of product standards and messaging development (e.g., communication and campaigns). The overarching goal of this project is to conduct systematic reviews and synthesize DCE evidence on product standards and messaging development, further combining existing DCEs with Nielsen Retail Scanner data and nationally representative surveys to improve the accuracy of policy impact prediction by mitigating hypothetical bias in DCEs.

PI_NAMEs: SHANG, CE  (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: addiction;Address;Adopted;Adult;Area;authority;Behavior;behavior prediction;Calibration;Characteristics;combustible tobacco;Communication;Consumer Preferences;Data;design;Development;Elasticity;Electronic cigarette;electronic cigarette user;Experimental Designs;experimental study;Future;Goals;Guidelines;Health;heated tobacco products;improved;Literature;Low Prevalence;Marketing;Measures;Meta-Analysis;method development;Methodology;Methods;Motion;Nicotine;non-smoker;Oral;Pattern;Persons;Policies;Population;preference;Price;Protocols documentation;Public Health;Regulation;Reporting;Research Personnel;response;Risk;risk perception;Shapes;Smoking;Surveys;systematic review;Tobacco;tobacco advertising;tobacco products;tobacco regulation;tobacco smokers;Tobacco use;tool;United States Food and Drug Administration;Variant;Visit;willingness to pay;young adult;Youth

PROJECT_TITLE: Utilizing tobacco discrete choice experiments to predict the population impacts of FDA regulatory policies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Z(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Respiratory dysfunction after spinal cord injury is the primary public health concern. The proposed study is designed to test a novel therapeutic strategy to fight this complication by using respiratory training in combination with electrical spinal cord stimulation applied transcutaneously in patients with chronic spinal cord injury. This knowledge will help to reduce the burden of human disability.

PI_NAMEs: OVECHKIN, ALEXANDER VLADIMIROVICH (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Activities of Daily Living;Acute;Blood Pressure;Breathing;Cardiovascular system;Chronic;Clinical;comparative;Complication;COVID-19;Cutaneous;Data;design;Development;disability;effectiveness evaluation;Effectiveness of Interventions;Electromyography;Electrophysiology (science);Evaluation;evidence base;fighting;follow-up;functional improvement;functional outcomes;Goals;Heart Rate;Human;improved;Individual;Injury;kinematics;Knowledge;Lesion;Lung;Measures;Methods;Modality;Morbidity - disease rate;mortality;Motor;motor control;Muscle;neural network;Neurologic;Neuronal Plasticity;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel therapeutic intervention;Patients;Pattern;Physiological;Population;preservation;pressure;Property;Protocols documentation;Public Health;Pulmonary function tests;Randomized Controlled Clinical Trials;rehabilitation strategy;Rehabilitation therapy;Research;Respiration;Respiration Disorders;respiratory;Respiratory Muscles;Respiratory physiology;response;restoration;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord Lesions;standard of care;Surface;Testing;Therapeutic Effect;Time;Training;transcutaneous stimulation;voltage;Work

PROJECT_TITLE: Neuromodulatory rehabilitation for respiratory motor function in individuals with chronic spinal cord injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: OMEROS CORPORATION

ORG_STATE: WA

PHR: Project Narrative This project addresses the critical need for an effective treatment for cocaine use disorder, for which there are no approved drugs. Successful completion of this project will lead to the development of the first oral treatment for cocaine use disorder that reduces cocaine craving and addiction. Given the millions of people worldwide with CUD and the tens of thousands of cocaine-related deaths each year, this new treatment will have enormous public health benefits.

PI_NAMEs: GAITANARIS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: Acceleration;addiction;Address;Adult;adverse outcome;Anesthesiology;Animal Model;Behavior Therapy;Brain region;Cardiac;Cardiovascular system;Cessation of life;Chronic;Clinic;Clinical;Clinical Research;Clinical Trials;Cocaine;Cocaine Abuse;cocaine craving;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;craving;Data;Development;Disease;Dopamine;dopamine system;Dose;Double-Blind Method;Dropout;drug candidate;Drug Interactions;Drug Kinetics;drug of abuse;Drug usage;drug withdrawal;effective therapy;Effectiveness;Enzymes;Exposure to;extracellular;Future;Goals;Health Benefit;healthy volunteer;Human;Hypertension;Individual;inhibitor;Inpatients;Intravenous;Investigational Drugs;Investigational New Drug Application;Link;Macaca fascicularis;Measures;Medical;Medicine;meetings;monoamine;Neurotransmitters;nonhuman primate;novel;Oral;Outcome;Overdose;Pain;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase I Clinical Trials;phosphoric diester hydrolase;Physiological;Placebos;pre-clinical;pre-Investigational New Drug meeting;primary outcome;psychosocial;Public Health;Randomized;Rattus;Relapse;reuptake;Rewards;Safety;safety study;safety testing;secondary outcome;small molecule;Specific qualifier value;Tachycardia;Testing;Therapeutic Agents;Toxicology;volunteer;Writing

PROJECT_TITLE: PDE7 Inhibitor for the Treatment of Cocaine Use Disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Following a recombinant design approach, we will develop and characterize a series of kidney- specific radionuclide imaging probes for targeting the structures and functions of the kidney. The proposed studies are designed to accomplish our research goal of assessing renal pathophysiology in diseases in a minimally invasive fashion with molecular specificity.

PI_NAMEs: JIN, JING  (contact);ZHAO, MING

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acute;Address;Autoimmunity;Basement membrane;Binding;Biopsy;Blood;blood filtration;Cells;Chimeric Proteins;Chronic;Chronic Phase;Circulation;Clinic;Clinical;collaborative environment;Dangerousness;Data;Defect;density;design;Detection;Diagnosis;Diagnostic;Disease;disease model;Early Diagnosis;Electrolytes;Excretory function;Extravasation;Filtration;functional decline;Functional disorder;glomerular filtration;Glomerulonephritis;glomerulosclerosis;Goals;Human;Hybrids;Hypertension;IgG1;Image;imaging agent;imaging approach;imaging probe;Imaging Techniques;Impairment;Individual;innovation;insight;Investigation;Ischemia;Kidney;kidney biopsy;kidney cortex;Kidney Diseases;Lead;Ligands;Liquid substance;Longitudinal Studies;Maps;Masks;Measurement;Measures;Metabolic;minimally invasive;Molecular;mouse model;neonatal Fc receptor;Nephrology;Nephrons;nephrotoxicity;novel;novel strategies;Onset of illness;Organ;Outcome;Pathologic;Pathology;Patient Care;personalized diagnostics;Plasma Proteins;Pre-Clinical Model;Procedures;Process;Protein Engineering;Protein Sortings;Proteins;Proteinuria;Radioisotopes;Radionuclide Imaging;rational design;receptor;Recombinants;Renal function;Renal glomerular disease;Reperfusion Injury;Research;Resolution;Resources;reuptake;Rodent Model;Route;Sclerosis;Secondary to;Series;Sorting;Specificity;standard of care;Structure;System;targeted agent;Techniques;Technology;Testing;Time;tool;Tracer;Translations;Tubular formation;uptake;urinary;Urine;Urology;VEGFA gene;wasting;Work

PROJECT_TITLE: Rationally Designed, Target-specific Imaging Probes for Nephro-urology Diagnoses

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DERMATOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: NARRATIVE Human papillomaviruses (HPV) encode proteins that can cause abnormal growth of infected cells. We have identified drug-like molecules that inhibit the function of a specific viral protein and reduce growth of HPV- containing cells. Using a multidisciplinary approach, we propose studies that will enable us to design drug-like HPV inhibitors and explore their activity in cells.

PI_NAMEs: ANDROPHY, ELLIOT J. (contact);MEROUEH, SAMY

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: adduct;Affinity;Algorithms;Alkynes;antagonist;Apoptosis;Applications Grants;Binding;Binding Sites;Biochemical;Biological;Biological Assay;cancer cell;Cancer cell line;Carcinoma in Situ;Cell Culture Techniques;cell killing;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;cellular targeting;Cervical;Charge;chemical synthesis;Clinical Trials;Complex;Computing Methodologies;covalent bond;Crystallization;Crystallography;Cysteine;Data;design;DNA;Docking;Drug Design;drug isolation;drug-like compound;Episome;Epithelial Cells;Epithelium;Evaluation;Exhibits;expectation;FDA approved;first-in-human;Funding;Genome;Goals;Grant;Growth;high risk;HPV negative;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 18;improved;In Vitro;Induction of Apoptosis;Infection;inhibitor;insight;interdisciplinary approach;Interferometry;Kinetics;Maintenance;Malignant - descriptor;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mass Spectrum Analysis;Mediating;meter;Methods;Modification;Molecular;Neoplasm Metastasis;novel;Oncogenic;Oropharyngeal;Papillomavirus Transforming Protein E6;Parents;Pathology;Peptides;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;preclinical evaluation;predictive modeling;premalignant;prevent;Prevention;Process;Property;protein protein interaction;Proteins;Reaction;reaction rate;recruit;Research Personnel;Resolution;Risk;Roentgen Rays;scaffold;screening;senescence;Series;Serine;Site;small molecule;small molecule libraries;Specificity;structural biology;Structure;Surface;Techniques;Testing;Time;Topical application;TP53 gene;tumor progression;Tumor Suppressor Proteins;UBE3A gene;ubiquitin ligase;Viral;Viral Genome;Viral Proteins;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Myelin regeneration often fails in Multiple Sclerosis (MS) and human neonatal hypoxic injury leading to Cerebral Palsy (CP), and contributes significantly to ongoing neurological dysfunction and disease progression. Here we identify primary cilia as a critical new signaling module that controls the oligodendrocyte progenitor cell (OPC) response to white matter injury, identify how the cilium controls OPC behavior and the ciliary controlled signaling mechanisms within OPCs, and map the proteome of OPC primary cilia during development and remyelination in vivo. This grant will show that primary cilia signaling is a key effector of biological change in OPCs, and will identify potential therapeutic targets for debilitating conditions such as MS and CP, where white matter injury repair can be dysfunctional.

PI_NAMEs: FANCY, STEPHEN PHILIP JAMES (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Adult;Affect;Agonist;Area;Biological;Blood Vessels;Catalogs;cell behavior;Cell Communication;Cell Culture Techniques;Cell Proliferation;cell type;Cells;Cellular biology;Central Nervous System Diseases;Cerebral Palsy;Cilia;Collaborations;CREB1 gene;Cues;Cyclic AMP;Data;Demyelinations;Development;Disease;Disease Progression;Enzymes;Erinaceidae;Failure;G-Protein-Coupled Receptors;Gene Expression;Gene Targeting;Genes;Grant;Homeostasis;Human;hypoxia neonatorum;Image;In Vitro;in vivo;Injury;injury and repair;insight;Label;Lesion;Letters;LoxP-flanked allele;Mammalian Cell;Maps;Mediating;Methods;Microtubules;migration;mRNA sequencing;Multiple Sclerosis;Multiple Sclerosis Lesions;Mus;Myelin;Myelin Sheath;Natural regeneration;Nature;neonatal human;Nervous System Disorder;Neurologic Dysfunctions;newborn brain injury;oligodendrocyte progenitor;Organelles;Pathway interactions;Pericytes;pharmacologic;precursor cell;programs;Proliferating;Proteins;Proteome;recruit;Regulation;remyelination;repaired;response;response to injury;Rest;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Slice;Spinal Cord;stem cell population;stem cells;Surveys;Techniques;therapeutic target;Tissues;tool;Transducers;Transgenic Organisms;Visualization;white matter;white matter injury

PROJECT_TITLE: Mechanisms of oligodendroglial ciliary function in white matter injury repair

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Gamma oscillations are produced in the primary motor cortex during reaching or exploratory movements and disrupted by disease. This proposal uncovers how gamma oscillations coordinate neurons in primary motor cortex and determines their behavioral relevance. Understanding this is important for interpreting their dysfunction in clinical populations and devising better therapies.

PI_NAMEs: HEADLEY, DREW BATTENFIELD (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Coordination of M1 projection neuron subtypes by oscillations

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE The goal of the Clinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program at UCSF is to train the next generation of clinical pharmacologist researchers so that they may pursue independently funded careers as academic investigators or clinical pharmacologists who can translate advances in biomedical research to the discovery, development and use of pharmacological therapies. We achieve this goal through a rigorous program structure of mentored research training accompanied by didactic coursework and participation in a biweekly seminar series. Throughout the course of the training program, trainees are exposed to a wide variety of research topics and interests leading to the development of a well-trained and diverse group of clinical-scientist investigators who will serve as tomorrow's leaders in clinical pharmacology research and practice in academia as well as the pharmaceutical, biotechnology industries and regulatory agencies.

PI_NAMEs: SAVIC, RADOJKA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Clinical Pharmacology, Drug Action and Pharmacogenetics


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Genetic mutations characteristic of myeloid neoplasms can be detected in the blood of up to 80% of healthy individuals over age 50 using sensitive genomic sequencing, a phenomenon termed clonal hematopoiesis (CH). While CH does increase the risk of blood cancer development, it does not predestine an individual for future disease progression, and as such, major unresolved questions are what factors promote expansion of these mutant clones in certain people and can these mechanisms be exploited to prevent disease progression in “at-risk” individuals? Here, we will investigate the role of inflammatory signals in providing a selection pressure for preferential growth of clones with DNMT3A mutations and identify novel points for potential disease interception.

PI_NAMEs: CHALLEN, GRANT ANTHONY (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: adult stem cell;Age;age related changes;Autoimmune Diseases;Automobile Driving;Biological Assay;Blood;Bone Marrow;Bone Regeneration;Bone remodeling;cancer prevention;Candidate Disease Gene;Cell division;Cells;Characteristics;Chronic;Clinical;Clonal Expansion;Clonal Hematopoietic Stem Cell;cohort;Collaborations;conditioning;cytokine;Data;Development;Disease;Disease Progression;DNA Modification Methylases;DNA Sequence Alteration;DNMT3a;DNMT3a mutation;driver mutation;Dysmyelopoietic Syndromes;Elderly;Environment;environmental stressor;Enzymes;experimental study;fitness;Funding;Future;Gene Frequency;Genes;Genetic;genetic variant;Genomics;Genotype;Goals;Growth;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;High Prevalence;high risk;high risk population;Human;human old age (65+);in vivo;Individual;Infection;Inflammation;Inflammatory;interest;Interferon Type II;Intervention;Life;Malignant Neoplasms;microbial;Modeling;Molecular;mouse model;mutant;Mutant Strains Mice;Mutate;Mutation;Myeloproliferative disease;Neoplasms;novel;Pathway interactions;Patients;Persons;pharmacologic;preservation;pressure;prevent;Process;Production;Publishing;recruit;Recurrence;Resistance;Resources;response;Risk;risk mitigation;Role;Serum;Signal Transduction;stem cell exhaustion;stem cell function;Stress;Symptoms;System;T cell infiltration;T-Lymphocyte;Testing;therapy development;Time;tool;Ulcerative Colitis;Up-Regulation;Variant;virtual;Work

PROJECT_TITLE: Inflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCs

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


PHR: Project Narrative Relevance to Public Health: The newest generation of physician scholars recognizes the need for global approaches to HIV prevention but lacks structured opportunities for research training in international sites. Our dedicated program of education and practical training in international HIV prevention studies fills an important deficit in current AIDS research.

PI_NAMEs: CLARK, JESSE LAWTON (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Admission activity;AIDS prevention;Area;Behavioral;behavioral health;Biological;career;Clinical;Collaborations;collaborative approach;Communities;Data;Data Analyses;Dedications;design;Development;Diagnosis;Diagnostic;diagnostic technologies;didactic education;Discipline;Education;Environment;Epidemiology;epidemiology study;Ethics;experience;Faculty;faculty mentor;Faculty Workshop;Foundations;Funding;Generations;Geographic Locations;global health;Goals;Health system;HIV;Human;human subject;Individual;Infrastructure;infrastructure development;innovation;Institution;institutional capacity;Instruction;inter-institutional;interdisciplinary approach;Interdisciplinary Study;interest;International;Intervention;investigator training;Journals;Knowledge;Laboratories;Latin America;Latin American;Learning Module;lectures;lens;Maintenance;meetings;Mentors;Modeling;multidisciplinary;Nature;novel diagnostics;pandemic disease;Participant;Pattern;Peer Review;Peru;Physicians;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;Prevention Research;preventive intervention;programs;Protocols documentation;Public Health;Research;Research Personnel;Research Project Grants;research study;Research Training;Resources;Risk Reduction;secondary analysis;Series;Site;skills;social;South American;Structure;symposium;System;Textiles;Time;tool;Training;Training and Education;Training Programs;transmission process;United States National Institutes of Health;Writing

PROJECT_TITLE: South American Program in HIV Prevention Research (SAPHIR)


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Motile cilia are microtubule-based organelles that produce a driving force for cellular locomotion or fluid flow. In humans, defects in motile cilia can lead to infertility, chronic respiratory disease, and even reversal of the orientation of the bodily organs. This project aims to reveal the detailed workings of the mechanoregulatory network that controls ciliary motility, which will help us to better understand the molecular basis of cilia-related diseases.

PI_NAMEs: BROWN, ALAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Mechanoregulation of Ciliary Motility

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]