NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with severe impairment of memory, cognition and executive functions that has a tremendous health and economic burden as more people live longer. Neurovascular unit (NVU) damage, blood-brain barrier (BBB) dysfunction and extracellular matrix (ECM) disruption play a key etiological role in AD progression; yet the contribution of genetic and/or environmental risk factors for brain vascular pathology is unclear. This project will focus on AD genetic risk factor and isogenic control astrocytes, a key component of the NVU, and how they are altered in function including after being chemically aged in both monolayer culture and 3D multicellular NVU systems.

PI_NAMEs: AGALLIU, DRITAN ;SPROUL, ANDREW ALEXANDER (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Adherent Culture;Advanced Glycosylation End Products;age related;aged;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Astrocytes;Autopsy;Biological;Biological Process;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood perfusion;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Cell Line;Cells;cerebrovascular;Chemicals;Cognition;CRISPR/Cas technology;Disease Progression;Economic Burden;Environment;Environmental Risk Factor;Etiology;executive function;Extracellular Matrix;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Health;Human;human pluripotent stem cell;human RNA sequencing;Image;Impaired cognition;Impairment;in vivo;Knock-in;Memory impairment;Methodology;Microfluidics;microphysiology system;Modeling;Molecular;monolayer;Morphology;mutant;Mutation;Neurodegenerative Disorders;neurovascular;neurovascular unit;novel;Pathology;Patients;Perfusion;Pericytes;Persons;Phenotype;Physiological;Plasma;Play;pluripotent stem cell differentiation;Pluripotent Stem Cells;Population;Property;Proteasome Inhibitor;Protocols documentation;Risk Factors;risk variant;Role;senescence;Signal Pathway;single nucleus RNA-sequencing;single-cell RNA sequencing;System;tau aggregation;transcription factor;transcriptome;transdifferentiation;Vascular Diseases

PROJECT_TITLE: Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's disease


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: FORT COLLINS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative: Cross-species transmission events from animal hosts gave rise to several deadly human pathogens including the recent SARS-CoV-2. Simian Immunodeficiency Viruses (SIV) in West and Central Africa gave rise to HIV-1 and HIV-2 from chimpanzee SIVcpz and sooty mangabey SIVsm, respectively. To prepare for future incidents such as these, the main goal of our proposed studies is to evaluate select SIVs, namely SIVrcm from red capped mangabeys and SIVmnd from mandrills for their potential for human transmission using a human surrogate hu- mouse animal model. This will be the first time these above viruses will be examined in an in vivo setting and the results from here will contribute to our knowledge on the initial steps in cross-species transmission and lay the ground work for using this model for evaluating other potentially zoonotic viral candidates in the future.

PI_NAMEs: AKKINA, RAMESH  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: 2019-nCoV;Acceleration;Animal Model;Animals;B-Lymphocytes;Blood;BLT mice;Budgets;CD34 gene;CD4 Positive T Lymphocytes;Cells;Central Africa;Cercocebus;Cercocebus atys;Co-Receptor Switch;Complex;cost;cost effective;cross-species transmission;Dendritic Cells;Development;Disease Outbreaks;Engraftment;Epidemic;Event;Evolution;Fetal Liver;fitness;Future;Generations;Goals;Grant;Habitats;Hematopoietic;HIV;HIV-1;HIV-2;Human;human pathogen;humanized mouse;Immune system;implantation;In Vitro;in vivo;Infection;Injections;Knowledge;Link;Macaca;Macrophage;Mandrillus sphinx;Modeling;monocyte;mouse model;Mus;neonatal mice;nonhuman primate;Operative Surgical Procedures;Pan Genus;pandemic disease;Pathogenicity;permissiveness;Population;predictive modeling;Predisposition;progenitor;Research;Route;Serial Passage;Sexual Transmission;SIV;stem cells;System;T-Cell Depletion;T-Lymphocyte;Testing;Thymic Tissue;Time;transmission process;Transplantation;trend;Tropism;vaginal mucosa;Viral;Viral Load result;viral transmission;Virus;Virus Diseases;Work;Zoonoses

PROJECT_TITLE: SIV zoonosis using humanized mice

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Down's syndrome (DS), the most common genetic cause of intellectual disability, is associated with a wide range of cognitive and behavioral impairments. Through the use of cutting edge MRI technology that allows us to look at the shape, function, and connections within the brain, we will be able to study and better understand early brain development in infants with DS. Working toward the goal to be able to assess the impact of specific early intervention therapies that are most helpful in improving the developmental outcomes of children with DS. This study mirrors and expands on the study designs and techniques that were developed to study infants with autism spectrum disorder (ASD), Fragile X, and typically developing infants, and will allow us to further our understanding of maturation patterns of infant brains that we can apply to DS, ASD, Fragile X, and other disabilities.

PI_NAMEs: MARRUS, NATASHA  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Administrative Supplement;Age;Area;autism spectrum disorder;Behavior assessment;Behavioral;behavioral impairment;Biological Markers;Brain;brain behavior;Brain imaging;Cerebellum;Characteristics;Child;Clinical Sciences;Cognitive;cohort;Collaborations;comorbidity;comparative;COVID-19;Cross Presentation;Data;Data Analyses;Data Collection;Data Set;Development;Developmental Disabilities;Diagnosis;disability;Down's Syndrome;Early Intervention;Early treatment;efficacy evaluation;Enrollment;Ensure;experience;follow-up;Foundations;Fragile X Syndrome;frontal lobe;frontier;Functional impairment;Functional Magnetic Resonance Imaging;Future;Genetic;Goals;high risk;Human;Image;imaging study;Impaired cognition;Impairment;improved;Incidence;Individual;infancy;Infant;Intellectual functioning disability;Intervention;Investigation;Knowledge;Life;Life Expectancy;Live Birth;Magnetic Resonance Imaging;Minnesota;MRI Scans;Multimodal Imaging;multimodality;National Institute of Child Health and Human Development;Nature;neural circuit;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;novel;Outcome;parent project;Pathogenicity;Pattern;personalized care;personalized intervention;Persons;pharmacologic;Population;predictive modeling;preservation;Productivity;prospective;Qualifying;Quality of life;Ramp;Recommendation;recruit;Research;Research Design;Series;Shapes;Site;skills;Sleep;Social Development;Specificity;Structure;support vector machine;Surface;Techniques;Technology;Testing;Therapeutic Intervention;Thick;Time;traditional therapy;United States;United States National Institutes of Health;Universities;Visit;white matter

PROJECT_TITLE: A Longitudinal MRI Study Characterizing Very Early Brain Development in Infants with Down Syndrome


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OAKWOOD

ORG_NAME: KILELE HEALTH INC.

ORG_STATE: OH

PHR: Project Narrative The Centers for Medicare & Medicaid Services has targeted reducing heart failure hospital readmissions as a major need, and recent clinical studies have shown that these readmissions can be significantly reduced through rapid treatment up-titration after heart failure diagnosis. Unfortunately, the technological infrastructure needed to support rapid treatment up-titration is insufficient for most health-care providers. This SBIR Phase 1 project will provide initial animal demonstration of the first ever factory-calibrated continuous molecular monitor for NT-proBNP and potassium in heart failure patients, for reducing hospital readmissions and adverse events during up-titration of heart failure treatment.

PI_NAMEs: SCHREIBER, SVEN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: absorption;Acceleration;Acute;Address;Adverse event;Age;Animal Testing;Animals;aptamer;Biosensor;Blood;Calibration;Cardiometabolic Disease;Cardiovascular Diseases;care delivery;career;Caring;Chronic Disease;Clinical;clinical practice;Clinical Research;commercialization;Continuous Glucose Monitor;cost;Data;Decentralization;Development;Devices;Diagnosis;Diagnostic Equipment;Disease Management;Electrodes;Electronic Health Record;expectation;experience;fabrication;Fingers;glucose monitor;Goals;Health;health goals;Health Personnel;Healthcare;Healthcare Systems;Heart Diseases;Heart failure;Heart Rate;heart rate variability;Home;hospital readmission;Human;improved;Infrastructure;innovation;Insulin-Dependent Diabetes Mellitus;Interview;Leadership;Letters;Marketing;Measures;Modeling;Molecular;molecular marker;Monitor;monitoring device;multimodality;Newly Diagnosed;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Population;Potassium;pressure;pro-brain natriuretic peptide (1-76);Process;product development;professional atmosphere;programs;Protocols documentation;Rattus;readmission rates;remote monitoring;Research Personnel;Resources;sensor;Skin;Small Business Innovation Research Grant;sobriety;sound;Stretching;success;Technology;Testing;Titrations;Treatment Efficacy;Treatment Failure;United States Centers for Medicare and Medicaid Services;Validation;Visit;wearable device;Work

PROJECT_TITLE: Initial Animal Validation of a Multimodal Molecular Monitor for Heart Failure Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Functional MRI (fMRI) is the most widely-used tool to measure human brain function and has contributed enormously to human neuroscience, however fMRI does not measure neuron firing rather it detects brain activity by measuring changes in blood flow in the brain that delivers oxygen to the neurons. These changes in blood flow that occur in the smallest blood vessels near to the neurons provide more accurate information about which neurons are firing, whereas it is more difficult to know the location of neuron firing when observing changes blood flow within the largest vessels, yet standard fMRI methods mix together signal from large and small blood vessels. Here we seek to develop MRI technology that can enable the observation of blood flow changes exclusively from the smallest blood vessels, and we will use this to show that these changes are faster than those found in the largest blood vessels and so our technology can therefore be used to better track rapid changes in neuron firing.

PI_NAMEs: POLIMENI, JONATHAN RIZZO (contact);SETSOMPOP, KAWIN

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Acceleration;Animal Model;Biological;Blood flow;blood oxygenation level dependent response;Blood Vessels;Brain;Cerebral cortex;Cerebrovascular Circulation;Cerebrovascular system;Coupled;Data;density;Dependence;Deposition;design;Detection;Echo-Planar Imaging;Endowment;Exhibits;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;Human;Image;image reconstruction;imaging study;Imaging technology;improved;Knowledge;Location;Magnetic Resonance Imaging;Measurement;Measures;Methods;Motion;Neurons;Neurosciences;novel;optical imaging;Oxygen;Phase;Photic Stimulation;Physiologic pulse;Protocols documentation;Resolution;response;Sampling;Signal Transduction;Slice;spatiotemporal;Specificity;Stimulus;Surface;Technology;temporal measurement;Testing;theories;Time;tool;Training;transmission process;Visual Cortex

PROJECT_TITLE: fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: In sub-Saharan Africa (SSA), despite major successes scaling up antiretroviral therapy (ART) for people living with HIV (PLWH), deaths continue to occur in 5-10% of PLWH during the first year after ART initiation. A significant number of these early deaths are likely attributed to lymphoproliferative disorders including lymphoma and multicentric Castleman disease, comorbidities caused by co-infections with Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. In this project, I propose to address these gaps in knowledge by 1) assessing multifactorial causes of diagnostic delay for cancer broadly and lymphoproliferative disorders specifically in Malawi, 2) comprehensively describe clinical characteristics and diagnoses in PLWH presenting with lymphadenopathy in community HIV clinics, and 3) assessing utility of novel molecular diagnostics to speed the diagnoses at an earlier stage and less invasively.

PI_NAMEs: PAINSCHAB, MATTHEW SCOTT (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Address;Africa South of the Sahara;antiretroviral therapy;Blood;Burkitt Lymphoma;Catchment Area;Cessation of life;Characteristics;Clinic;Clinical;co-infection;Communities;comorbidity;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic technologies;Dimensions;DNA;Electricity;Enrollment;Evaluation;Fine needle aspiration biopsy;Goals;Health;Herpesviridae;HIV;Human Herpesvirus 4;Human Herpesvirus 8;implementation barriers;implementation science;improved;improved outcome;innovation;isothermal amplification;Knowledge;lymph node biopsy;lymphadenopathy;Lymphoma;Lymphoproliferative Disorders;Malawi;Malignant Neoplasms;Measurement;Mediating;Methods;molecular diagnostics;Multicentric Angiofollicular Lymphoid Hyperplasia;Newly Diagnosed;novel;Participant;Pathologic;Patients;Peripheral;Persons;point of care;Population;Prevalence;preventable death;Rapid diagnostics;Research;scale up;skin biopsy;Skin Kaposi's Sarcoma;Speed;success;Testing;Time;Tuberculosis;tuberculosis treatment;Work

PROJECT_TITLE: Innovations in diagnosis for lymphadenopathy across HIV Centers of Excellence in Malawi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Rare genetic diseases are an emerging global public health priority that disproportionately affect children, causing early childhood death and long-term morbidity in the survivors. Inadequate access to genetics evaluation and genomic testing in the Hispanic minorities living along the Texas-Mexico has marginalized the most vulnerable pediatric group. This proposal aims to transform the current clinical practice paradigm by leveraging an internally designed web-based model of delivery of care to provide timely evaluation and genomic sequencing for improving genetic health of less resourced children with rare disorders.

PI_NAMEs: LALANI, SEEMA R (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Acceleration;access disparities;Adopted;Affect;Area;Caring;Cessation of life;Child;Child Care;child services;Childhood;Chronic;Clinic;Clinical;clinical care;clinical decision-making;clinical diagnosis;clinical practice;Clinical Research;Clinical Services;Collaborations;college;Communities;Community Outreach;Competence;Congenital Abnormality;Consultations;Country;Decision Making;design;Diagnosis;Diagnostic;Diagnostic Services;diagnostic tool;Disabling;Disease;early childhood;Education;Equity;ethnic minority;Evaluation;experience;Face;Family;follow-up;Genetic;Genetic Counseling;Genetic Diseases;genetic disorder diagnosis;genetic resource;Genetic Services;genetic testing;genome sequencing;Genomic medicine;Genomics;Goals;Health;health care availability;health literacy;Health Personnel;Health Professional;Health Sciences;Health Services Accessibility;Healthcare;Hispanic;improved;Income;Inequality;Infrastructure;Intelligence;Intervention;Latinx;Life;Life Expectancy;literacy;low socioeconomic status;lower income families;marginalization;Measures;Medical;medical complication;Medical Genetics;medically underserved;medically underserved population;Medicine;Mexican;Mexico;Minority;minority communities;Minority Enrollment;Modeling;Morbidity - disease rate;multidisciplinary;Neurodegenerative Disorders;Neurodevelopmental Problem;non-genetic;novel;Online Systems;Outcome;Pathway interactions;Patient Care;Patients;pediatric patients;personalized medicine;Phase;Physician Assistants;Physicians;Pilot Projects;Population;population based;Poverty;prevent;primary care practice;primary endpoint;Provider;public health priorities;rapid diagnosis;Rare Diseases;rare genetic disorder;Recommendation;Recording of previous events;recruit;Registries;Remote Consultation;research clinical testing;research study;Resources;Rural;rural area;Service delivery model;Services;Site;South Texas;Surveys;Survivors;System;Technology;Test Result;Testing;Texas;Time;Training;underserved area;Underserved Population;Uninsured;United States;Universities;urban area;virtual;virtual platform;Vulnerable Populations;web services;webinar

PROJECT_TITLE: Virtual Platforms for Genetics Evaluation in the Medically Underserved


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative This project seeks to shorten the diagnostic odysseys for rare genetic diseases, which can last for years, by using electronic health record-based identification of patients likely to have such disorders. In the first phase of the project, we will test out our existing algorithms for infants and children with a pilot study and also attempt to improve those algorithms. During the second phase of the project, we will develop algorithms for similar purposes but for adolescent and adult patients as well as deploy our algorithms in a different, non-academic health care setting.

PI_NAMEs: BALWANI, MANISHA ;GELB, BRUCE D (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Affect;Age;age group;aged;algorithm development;Algorithms;Ambulatory Care Facilities;Black race;Body System;Caring;Child;Childhood;Clinical;cohort;Community Hospitals;Computerized Medical Record;Data;Diagnosis;Diagnostic;Diagnostic tests;Disease;DNA;Drops;Education;Electronic Health Record;electronic health record system;electronic structure;Evaluation;evaluation/testing;Family;Genetic;Genetic Services;genetic testing;Goals;health care settings;Health Personnel;Healthcare;healthcare burden;Hispanic;Hospitals;improved;Infant;Internal Medicine;Knowledge;Manuals;Measures;Medical;Medical Genetics;Modeling;multidisciplinary;Natural Language Processing;New York City;novel;Outcome;outpatient programs;outreach;pandemic disease;patient population;Patients;pediatric patients;pediatrician;Phase;phenotyping algorithm;Pilot Projects;Population;Predictive Value;Process;programs;Rare Diseases;rare genetic disorder;Risk;Site;Surveys;telehealth;Testing;Time;Toddler;Training;trait;Underserved Population;working class;young adult

PROJECT_TITLE: Using electronic medical record data to shorten diagnostic odysseys for rare genetic disorders in children and adults in two New York City health care settings


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: Glasgow

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF GLASGOW

ORG_ZIPCODE: G12 8QQ

PHR: Project Narrative This project will lead to the digital standardisation of chemistry from analog synthesis and discovery of both known and unknown molecules of biological interest on any compatible hardware using a new programming language based upon our open-source chemical description language (χDL). We will leverage our expertise and invention of the Chemputer, a programmable chemical synthesis and discovery engine, to develop an architecture that can bridge commercial, bespoke, and new automation technologies and showcase this with specific hardware developments that will help create the missing link between automation workflows. We will apply our language and hardware pipeline that incorporates novel separation and workup technologies, as well as in-line spectroscopy, for the real-time synthesis, screening, and discovery of new chemical compounds for drug discovery

PI_NAMEs: CRONIN, LEE  (contact)

PROGRAM_OFFICER_NAME: RUDNICKI, DOBRILA DODA

PROJECT_TERMS: Algorithms;analog;Architecture;Area;Automation;Behavior;Biochemistry;Biological;Case Study;chemical reaction;chemical synthesis;Chemicals;Chemistry;Code;Collaborations;Computer Assisted;computer program;Computer software;Data;Data Correlations;Dedications;design;Development;digital;Disparate;drug candidate;drug development;drug discovery;Drug Screening;Electronics;Elements;Ensure;Environment;Equipment;experimental study;Feedback;Generations;Goals;High Pressure Liquid Chromatography;improved;Individual;innovation;interest;invention;Laboratories;Language;Lead;Libraries;Link;Liquid substance;Machine Learning;meetings;Membrane;Methods;Modeling;National Center for Advancing Translational Sciences;new chemical entity;novel;novel strategies;open source;operation;Organic Chemistry;Outcome;Pharmaceutical Preparations;Phase;Play;portability;Procedures;Process;Programming Languages;programs;Protocols documentation;prototype;Reaction;Research;Robot;Running;Schedule;screening;simulation;software systems;Solid;Specific qualifier value;spectroscopic data;Spectrum Analysis;Standardization;System;Technology;Testing;Time;Update;Validation;Work

PROJECT_TITLE: Discovery & Synthesis Chemputer: An intelligent universal system for automated chemical synthesis and discovery across different hardware and scales


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This study seeks to develop a high-throughput analytical and synthetic platform for drug discovery based on mass spectrometry. This technology will expand the capabilities of the NCATS ASPIRE laboratory, where it will provide unparalleled access to previously unexplored chemical space with potential to accelerate drug discovery. The newly developed system will be utilized to identify small bioactive molecules that target a key sulfate transfer enzyme involved in prostate cancer.

PI_NAMEs: COOKS, ROBERT GRAHAM (contact)

PROJECT_TERMS: Acceleration;Acetylcholinesterase;Address;Air;analog;analytical method;Bacteria;bioactive scaffold;Biological;Biological Assay;Biological Testing;Cancer Biology;Chemicals;chemotherapeutic agent;cholesterol sulfotransferase;Collaborations;Collection;Computer software;cost;data acquisition;Deposition;design;Development;Directed Molecular Evolution;drug candidate;drug discovery;Effectiveness;Electrospray Ionization;Enzyme Kinetics;Enzymes;Evaluation;experimental study;Extramural Activities;high throughput screening;improved;In Vitro;Infrastructure;insight;instrument;instrumentation;interest;ion source;ionization technique;Ions;Joints;Laboratories;Lead;Libraries;machine learning method;Malignant neoplasm of prostate;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;medical countermeasure;Methods;milligram;nano;nanoscale;National Center for Advancing Translational Sciences;nerve agent;new chemical entity;new technology;next generation;novel;novel therapeutics;Organic Synthesis;Outcome;Performance;Phase;Positioning Attribute;Preparation;Property;Qualitative Methods;Reaction;reaction rate;Reagent;Research;Research Personnel;robotic system;Route;Sampling;scaffold;Scientist;screening;Solvents;Spectrometry, Mass, Electrospray Ionization;Speed;Sulfate;Surface;System;Techniques;Technology;Testing;therapeutic development;Training;Use Effectiveness;Writing

PROJECT_TITLE: High throughput infrastructure for reaction screening and bioassays


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Precision Medicine;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Nonalcoholic fatty liver disease (NAFLD) is a worldwide public health problem, occurring in ~25% of the global adult population. Despite major investments by the pharmaceutical industry, there are no approved drugs for the treatment of NAFLD, reflecting the heterogeneous pathophysiology of this disease. We have begun implementing an all human-iPSC liver microphysiology system (MPS) platform to test drugs/drug combinations as potential NAFLD therapeutics. There is a critical need to develop and implement high content and throughput NAFLD MPS models based on iPSC-derived cells that demonstrate maximal reproducibility. The goal of this proposal is the development of a combined high throughput and high content NAFLD experimental model for a primary screen of predicted drugs and optimal combinations using human, patient-specific iPSC- derived liver cells bioprinted in transwell plates will transform the approach to NAFLD drug discovery to precision medicine. The more detailed analysis of the best drugs and drug combinations in the bioprinted version of the vLAMPS models will refine the selection of drugs/combinations for select patient cohorts.

PI_NAMEs: MIEDEL, MARK T. (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Animal Model;Biological Assay;Biological Models;Biomimetics;bioprinting;Biosensor;Cells;cohort;Collaborations;Collagen;Collagen Type I;Database Management Systems;design;Development;Disease;disease model;Disease Pathway;disease phenotype;Drug Combinations;Drug Controls;drug discovery;Drug Industry;Drug Modelings;Drug Screening;Drug Targeting;drug testing;Endothelial Cells;Engineering;Evaluation;Experimental Models;Fibrosis;Functional disorder;genotyped patients;Goals;hepatic acinus structure;Hepatocyte;Human;human disease;human induced pluripotent stem cells;improved;induced pluripotent stem cell;Inflammation;Insulin Resistance;Investments;Kupffer Cells;Laboratories;Lipids;Liver;Methodology;Microfluidics;microphysiology system;Modeling;National Center for Advancing Translational Sciences;non-alcoholic fatty liver disease;Pathology;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Population;precision medicine;Probability;progression marker;Proteins;Public Health;Publishing;Reproducibility;response;scale up;small molecule libraries;stellate cell;System;Testing;Therapeutic;Time;Tissue Model;Tissues;Universities;Vascularization

PROJECT_TITLE: Re-engineering a human 3D liver tissue model for non-alcoholic fatty liver disease for drug screening


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE To overcome the limitations of no existing drugs against preterm birth as well as challenges in conducting clinical trials during pregnancy, we will develop an in vitro model: a 3D bioprinted feto-maternal interface (part of uterine tissue) tissue chip that can model the disease state of pregnancy. In collaboration with the National Center for Advancing Translational Sciences (NCATS), the tissue chip model capable of conducting high- throughput screening of drug libraries will be utilized to test up to 1,000 drug compounds for their usefulness in treating pregnant women and their fetuses and for testing potential adverse effects of the drug compounds. Successful development of this high-throughput model will allow testing of many drugs currently in use for other clinical indications, but not for pregnant women due to uncertainty of their adverse effects on pregnancy, as well as initiating discovery of new drugs that can reduce the risk of preterm birth.

PI_NAMEs: HAN, ARUM ;MENON, RAMKUMAR  (contact)

PROJECT_TERMS: 3-Dimensional;Adverse drug effect;Adverse effects;Affect;Animal Model;Anti-Inflammatory Agents;Apoptosis;Biological Assay;bioprinting;Birth;Carrier Proteins;Cell Culture Techniques;cell immortalization;Cell model;Cells;Chorion;Clinical;Clinical Trials;Collaborations;Conduct Clinical Trials;cost;cytotoxicity;Decidua Basalis;decidua parietalis;Decidual Cell;design;Development;Disease;disease model;Drug Compounding;drug development;drug efficacy;drug metabolism;Drug Modelings;Drug Screening;drug testing;Drug toxicity;Drug Transport;Drug usage;efficacy testing;Extracellular Matrix;fetal;Fetal Membranes;Fetus;Gatekeeping;Gel;Gender;high throughput screening;high-throughput drug screening;Human;hydrogel scaffold;immune cell infiltrate;Immune Tolerance;Immunoassay;in utero;In Vitro;in vitro Model;Infection;Infiltration;Inflammation;Inflammatory Response;interest;Intervention;Kinetics;Libraries;Manuals;Maternal Mortality;Membrane;Metabolic;Microscopy;Modeling;Morbidity - disease rate;Mothers;Mus;National Center for Advancing Translational Sciences;Necrosis;neonatal morbidity;Neonatal Mortality;nonhuman primate;novel therapeutics;Outcome;Pathologic;Pathway interactions;Patients;Perfusion;Persons;Pharmaceutical Preparations;Phase;Placenta;Pravastatin;preclinical trial;Predisposing Factor;Pregnancy;Pregnant Women;Premature Birth;Race;rapid testing;Reporting;Research Personnel;response;Risk Factors;Risk Reduction;screening;Source;Structure;success;successful intervention;Teratogens;Term Birth;Testing;therapeutic candidate;Tissue Microarray;Tissue Model;Tissues;trafficking;trophoblast;Uncertainty;Uterine Contraction;Uterus

PROJECT_TITLE: 3-D biofabricated feto-maternal interface tissue model to determine drug efficacy during pregnancy to reduce the risk of preterm birth


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Clinical Research;Contraception/Reproduction;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Menopause;Primary Health Care;Women's Health Research

PHR: Project Narrative The primary goal of this proposal is to develop “EMPOWHer” Embracing Midlife and Menopause Positively: Offerings by Women with HIV, a virtual education program designed to enhance clinician knowledge and confidence with providing midlife health and menopause care to women with HIV(WWH). The EMPOWHer program will be co-created by WWH from diverse US geographic regions in partnership with transdisciplinary/transprofessional clinicians and researchers.

PI_NAMEs: BARES, SARA HURTADO;LOOBY, SARA ELIZABETH DOLAN (contact)

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Achievement;Address;Adherence;Advertisements;affective disturbance;Aging;aging population;AIDS prevention;antiretroviral therapy;Appointment;Area;associated symptom;care outcomes;Caring;Clinic;Clinical;clinical care;Collaborations;Communicable Diseases;Communication;Community Health;community organizations;Complex;Comprehensive Health Care;Consultations;Data;design;Development;Education;Educational Curriculum;Effectiveness;Ensure;Evaluation;evidence base;experience;Future;Gender;Geographic Locations;Goals;Guidelines;Health;Health education;health outcome disparity;Health Personnel;Heart Diseases;HIV;HIV diagnosis;Hormone replacement therapy;Hormones;Hot flushes;Individual;Inequity;innovation;Inpatients;insight;Knowledge;life span;Link;Lived experience;medical specialties;Menopause;middle age;Midlife women;Morbidity - disease rate;mortality;Newly Diagnosed;Nurses;older women;Osteoporosis;Outpatients;Perimenopause;Persons;Phase;Physicians;Postmenopause;Pregnancy;premature;Primary Care;primary care provider;Process;Program Evaluation;programs;prospective;Provider;Psychiatry;psychologic;Psychologist;Quality of life;Reproductive Health;Reproductive Periods;Research;Research Personnel;Resources;response;Science;screening;sex;Sleep disturbances;social;Social support;Specialist;stem;Stream;Surveys;Time;transgender women;Trauma;United States;virtual;virtual education;Vulnerable Populations;web site;webinar;Woman;women versus men;Women's Health;Work;Writing

PROJECT_TITLE: EMPOWHer: Embracing Midlife & Menopause Positively-Offerings by Women with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);Hematology;Mental Health;Orphan Drug;Rare Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: UHL, GEORGE RICHARD (contact)

PROGRAM_OFFICER_NAME: WHITE, DAVID A

PROJECT_TERMS: Address;Admission activity;American;amphetamine use;Amphetamines;analog;aryldialkylphosphatase;Attention deficit hyperactivity disorder;Biodistribution;Body Weight decreased;Canis familiaris;carcinogenicity;Chemistry;Clinical;Clinical Research;Cocaine;cocaine use;Cocaine use disorder;Data;Dose;Enzymes;experience;FDA approved;Funding;Half-Life;Hematology;Hepatic;Histopathology;Human;Intake;Kidney;Laboratory Research;Legal patent;Lesion;meetings;Metabolism;methamphetamine use;Microsomes;Mus;Narcolepsy;National Institute of Drug Abuse;new therapeutic target;No-Observed-Adverse-Effect Level;novel;Oral;Pattern;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 1 study;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Plasma;Protein Tyrosine Phosphatase;PTPN1 gene;Rattus;receptor;Recombinants;Reporting;Rewards;Rodent;Role;Self Administration;Series;Site;Stimulant;stimulant use;stimulant use disorder;Toxic effect;treatment program;Tubular formation;Validation;Work;Writing

PROJECT_TITLE: PTPRD phosphatase inhibitors for stimulant use disorders


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN DIEGO

ORG_NAME: 3DT HOLDINGS, LLC

ORG_STATE: CA

PHR: NARRATIVE Heart failure (HF) is a nationwide epidemic. Many HF patients are presented with left bundle branch block morphology and mechanical dyssynchrony, which are strong predictors of cardiovascular mortality. The purpose of this Phase-I proposal is to develop and validate a software tool for predicting patient-specific outcomes in order to optimize cardiac resynchronization and pacing therapies for HF patients.

PI_NAMEs: GUCCIONE, JULIUS MATTEO (contact);KASSAB, GHASSAN S

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Acute;Address;Affect;Algorithms;artificial intelligence model;Bundle-Branch Block;Cardiac;cardiac resynchronization therapy;Cardiovascular system;Cicatrix;Clinic;computer framework;Computer Models;Coronary;coronary perfusion;Coupled;Coupling;Data;Decision Trees;Development;Disease;Epidemic;Europe;experience;experimental study;Family suidae;Generations;Geometry;Grant;Health Care Costs;Heart;Heart failure;hemodynamics;Human;improved;Ischemia;ischemic cardiomyopathy;Lead;Left;Left ventricular structure;Letters;Location;Machine Learning;machine learning algorithm;Maps;Measurable;Mechanics;Modeling;Morphology;mortality;neural network;North America;novel strategies;Outcome;Output;Patients;Pattern;Perfusion;Phase;Physics;Physiological;Positioning Attribute;predictive tools;premature;preservation;pressure;Recommendation;Regulation;response;simulation;software as a medical device;Software Tools;success;System;Technology;Testing;therapy outcome;Time;timeline;tool;Training;Translating;treatment optimization;treatment response;Ventricular;ventricular assist device;Work

PROJECT_TITLE: Software Tool for Optimization of CRT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Pre-exposure prophylaxis (PrEP), a biomedical prevention intervention with proven effectiveness at preventing HIV transmission, is not widely accessed or used by cisgender Black women (CBW) in Houston/Harris County who are at significant risk for HIV through heterosexual sex. We propose to develop an innovative video-log (vlog) series intervention with single sessions that are specific to both CBW and healthcare providers (HCPs) of CBW, and assess its feasibility, acceptability, and preliminary impact through a pilot randomized controlled trial and a social media campaign. The vlog series will leverage relatable, culturally competent, and engaging narratives (i.e. stories) to increase willingness of 1) CBW in the Houston area to access and use PrEP and 2) HCPs in the Houston area to prescribe and refer PrEP to CBW.

PI_NAMEs: HILL, MANDY J (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Advocacy;Area;Awareness;Behavior;behavior change;Behavioral Mechanisms;black women;Caring;cis-female;cisgender;Client satisfaction;Communication;Communities;community advisory board;condoms;Consequences of HIV;County;cultural competence;Development;digital;Effectiveness;Eligibility Determination;Enrollment;epidemic preparedness;Facebook;Facial Expression;feasibility testing;Feedback;Female;Focus Groups;follow-up;Fostering;Foundations;Funding;Future;Gestures;Goals;Health;health communication;Health Personnel;Health Promotion;Healthcare;Heterosexuals;HIV;impression;improved;informant;Injections;innovation;Instagram;interest;Intervention;Interview;Knowledge;Lived experience;Marketing;Media Campaign;Medical;meetings;member;Neighborhood Health Center;novel;Outcome Study;outreach;Participant;Patients;Perception;Performance;Persons;pill;Pilot Projects;pilot test;Population;pre-exposure prophylaxis;prevent;Prevention;prevention service;preventive intervention;primary outcome;programs;Provider;Qualitative Research;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;Research Personnel;Risk;Secure;Series;sex;Sexual Health;skills;social;social media;social stigma;success;Tablet Computer;tailored messaging;Technology;Testing;Texas;Text;theories;Translating;transmission process;treatment as usual;trend;United States;United States National Institutes of Health;uptake;video delivery;Visit;Voice;willingness;Woman;Women's Health

PROJECT_TITLE: Leveraging video logs as a bridge to pre-exposure prophylaxis (PrEP) with tailored messaging to Black women and their healthcare providers in Texas

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetic Testing;Genetics;Human Genome;Nanotechnology;Precision Medicine

ORG_CITY: BEVERLY

ORG_NAME: SAGE SCIENCE, INC.

PHR: 8. Project Narrative Recent advances by the two major long-read sequencing companies, PacBio and Oxford Nanopore, have enabled complete sequencing of the human genome and as a result, many major genomic research programs and genetic testing companies are racing to implement long-read whole genome sequencing (WGS) as a standard of care for genetic testing in the near term, and for comprehensive precision medicine programs in the future. For such an effort to succeed, long read sequencing workflows must be adapted to use high- throughput automated liquid handling equipment to further reduce sequencing costs, to improve workflow reproducibility, and to eliminate sources of operator error. This grant proposal seeks to accelerate implementation of long-read sequencing in precision medicine (and genomic research broadly) by creating a high-throughput, flexible, cost-effective size-selection system for DNA sequencing library preparation that is easy to integrate with standard liquid handling robotics.

PI_NAMEs: BOLES, TRUETT C (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Acceleration;Agar Gel Electrophoresis;All of Us Research Program;Applications Grants;Biological Assay;biological research;Buffers;Cells;clinical sequencing;cost;cost effective;design;Development;Diffusion;DNA;DNA Library;DNA sequencing;Electrodes;Electrophoresis;Elements;Equipment;fetal;flexibility;Future;Gel;Genetic Diseases;genetic disorder diagnosis;genetic testing;genome sequencing;Genomic medicine;Genomics;human genome sequencing;human pangenome;improved;instrumentation;Libraries;Link;liquid biopsy;Liquid substance;magnetic beads;Measurement;Methods;molecular sequence database;Molecular Weight;Monitor;nanopore;novel therapeutics;operation;Output;patient health information;Performance;Physiologic pulse;Plasma;platinum electrode;Positioning Attribute;Power Sources;Precipitation;precision medicine;Preparation;printed circuit board;programs;Property;Race;Reproducibility;Research;Robot;Robotics;Running;Sampling;Sepharose;sequencing platform;Services;Source;standard of care;System;Technology;Time;tumor;United States National Institutes of Health;voltage;waveguide;whole genome

PROJECT_TITLE: High-throughput size-selection system for long-read sequencing library preparation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The Congenital and Perinatal Infections Consortium (CPIC) brings together a group of 28 study sites that have a longstanding history of research in pediatric infectious diseases with community and industry stakeholders. Together, they will work to recruit the rare populations needed to further research in the areas of congenital cytomegalovirus disease, neonatal herpes simplex virus infection, and neonatal viral sepsis. They will also train future rare diseases researchers using a pilot research program and career enhancement activities.

PI_NAMEs: KIMBERLIN, DAVID W (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: 2 year old;Alabama;Anti-viral Agents;Anti-viral Therapy;Area;Blindness;burden of illness;Cardiac;career;career development;Cessation of life;Child Care;Childhood;Clinical;clinical development;Clinical Research;clinical trial readiness;Cloud Computing;Collaborations;Common Data Element;Communicable Diseases;Communities;congenital cytomegalovirus;Congenital herpes simplex;congenital infection;Cytomegalovirus;Data;Data Coordinating Center;data standards;Development;Diagnosis;Disease;Dose;Drug Kinetics;Enrollment;Enterovirus;experience;Exposure to;Faculty;Family;Funding;Future;Future Generations;Goals;Health;Hearing;hearing impairment;Herpes Simplex Infections;Human;improved;improved outcome;Industry;infancy;infant infection;Infection;Infrastructure;Institution;Lead;Longitudinal Studies;Mentors;Modeling;Morbidity - disease rate;mortality;Motor;Multi-site clinical study;Natural History;Neonatal;Neonatal Mortality;neonatal sepsis;neonate;Neurologic;novel therapeutics;Organ;Outcome;Parechovirus;pathogenic virus;Pathogenicity;Patient Care;Perinatal;Perinatal Infection;pharmacometrics;phase 1 study;Population;Positioning Attribute;programs;Randomized;Rare Diseases;Rare Infectious Disease;Recording of previous events;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;respiratory;Science;Sepsis;Septic Shock;Series;Simplexvirus;Site;success;Testing;Therapeutic Agents;Time;Training;treatment effect;trial design;United States Food and Drug Administration;United States National Institutes of Health;Universities;valacyclovir;Valganciclovir;Viral;Viremia;Virus;Virus Diseases;Visceral;Work

PROJECT_TITLE: Congenital and Perinatal Infections Rare Diseases Clinical Research Consortium (RDCRC)


NIH_SPENDING_CATS: Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PROJECT_TERMS: Advisory Committees;Area;biomarker evaluation;Biometry;burden of illness;career;Childhood;Clinical Research;clinical trial readiness;Clinical Trials;Collaborations;Communicable Diseases;Communication;congenital cytomegalovirus;Congenital herpes simplex;congenital infection;Cytomegalovirus;Data;Data Coordinating Center;data management;Development;Diagnosis;Disease;Effectiveness;Elements;Ensure;Enterovirus;experience;Feedback;Foundations;Future;Heart;Herpes Simplex Infections;Human;improved;Individual;Infrastructure;innovation;Knowledge;Laboratories;Leadership;Mission;Modeling;Monitor;Neonatal;operation;Parechovirus;patient population;pediatric department;Perinatal Infection;Personnel Management;pharmacometrics;Policies;Population;Principal Investigator;Procedures;Process;programs;Protocols documentation;Publishing;Rare Diseases;Research;Research Personnel;Research Project Grants;Resources;Sepsis;Site;skills;Structure;success;Time;Training;trial design;Viral;Virus Diseases;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Hearing Loss;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PROJECT_TERMS: 12 year old;2 year old;Adolescent;Age;Alabama;Animal Model;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Audiology;Back;Birth;cancer diagnosis;carcinogenicity;Child;Clinical Research;Clinical Treatment;cohort;congenital cytomegalovirus;congenital infection;Cytomegalovirus;design;Development;Developmental Delay Disorders;Disease;Enrollment;experience;follow-up;Follow-Up Studies;Funding;Future;Ganciclovir;Hearing;improved;infancy;Infant;Institution;Intelligence;Knowledge;Life;Longitudinal Studies;Longterm Follow-up;Malignant Neoplasms;Medical History;Mental Retardation;neonate;neurodevelopment;non-genetic;Oral;Outcome;Patients;Perinatal Infection;Population;Prodrugs;prospective;Puberty;Publishing;Randomized;Rare Diseases;recruit;Safety;Sensorineural Hearing Loss;Site;Study Subject;symptom treatment;Teratogens;Testing;Time;Toxic effect;treatment duration;treatment effect;United States National Institutes of Health;Universities;Valganciclovir;Viral

PROJECT_TITLE: Longitudinal CMV


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Hematology;Infectious Diseases;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sepsis

PROJECT_TERMS: Activated Partial Thromboplastin Time measurement;Adenoviruses;adverse outcome;Alanine Transaminase;Anti-viral Agents;antiviral drug development;Aspartate Transaminase;Bilirubin;Biological Markers;Blood;Blood Coagulation Disorders;Blood specimen;Blood Urea Nitrogen;California;Case Series;Child;Circulation;Clinical;Clinical Research;clinical trial readiness;Coagulation Process;congenital infection;Creatinine;Cytomegalovirus;Data;Death Rate;design;Development;Echocardiography;efficacy study;EFRAC;Enrollment;Ensure;Enterovirus;Etiology;experience;Fibrin fragment D;follow-up;Funding;Future;Hematocrit procedure;Hemoglobin;Hepatitis;Human;improved;improved outcome;inclusion criteria;Infant;Infection;interest;Knowledge;Laboratories;Life;Literature;long-term sequelae;Meningoencephalitis;Methodology;Molecular Diagnostic Testing;Morbidity - disease rate;mortality;Myocarditis;Natural History;Neonatal;neonatal human;Neonatal Mortality;neonate;next generation sequencing;novel;Organ;Outcome;Parechovirus;pathogen;Pattern;Performance;Perinatal Infection;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Platelet Count measurement;Polymerase Chain Reaction;Population;population based;prospective;Prothrombin time assay;Publishing;Pulmonary Inflammation;Rare Diseases;Recording of previous events;Sample Size;San Francisco;Seasons;Sepsis;Severity of illness;Shortening Fraction;Simplexvirus;Specimen;Survivors;Syndrome;Technology;Therapeutic Trials;Thrombocytopenia;tool;trial readiness;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Viral;viral detection;Viral Load result;Viremia;Virus;White Blood Cell Count procedure

PROJECT_TITLE: EV Sepsis Natural History


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acyclovir;Adult;Adverse event;age group;Age Months;Alanine Transaminase;Anti-viral Therapy;Biological Assay;Biological Availability;Birth;Cessation of life;Child;Classification;Clinical Research;Collaborations;Congenital herpes simplex;congenital infection;Creatinine;Data;detection platform;Development;Diagnostic;diagnostic platform;Diagnostic tests;Disease;Dose;Drug Kinetics;efficacy study;emotional distress;Enrollment;Event;Exposure to;female reproductive tract;Funding;Future;genital infection;Goals;Hemoglobin;Herpes Simplex Infections;high risk;improved;Incidence;Infant;Infection;Intervention;Label;Laboratories;Left;Modeling;Morbidity - disease rate;mortality;mortality risk;Mothers;Myelosuppression;neonatal infection;neonate;Nervous System Trauma;Neurologic;novel;older patient;Onset of illness;Oral;Oral Administration;Outcome;Perinatal;Perinatal Infection;Phase;phase 3 study;phase I trial;Placebos;Platelet Count measurement;point of care;point-of-care diagnostics;Polymerase Chain Reaction;Population;Pregnant Women;prevent;Process;Prodrugs;rapid test;Rare Diseases;Recommendation;reproductive tract;Research;Risk;Safety;safety assessment;Sampling;Simplexvirus;standard care;Standardization;Swab;Symptoms;Telephone;Testing;Therapeutic Intervention;Time;Toxic effect;transmission process;Treatment Efficacy;trial readiness;unethical;United States National Institutes of Health;Vagina;valacyclovir;Viral;viral DNA;Virus;Virus Diseases;Visit;White Blood Cell Count procedure;Woman

PROJECT_TITLE: Valacyclovir Phase I Trial


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Hearing Loss;Infectious Diseases;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Adverse event;Affect;African American;Age;Age Months;Allogenic;Anti-viral Agents;Anti-viral Therapy;Asian Americans;Birth;Childhood;Cidofovir;Clinical;Clinical Research;Clinical Trials;cohort;Combined Modality Therapy;congenital cytomegalovirus;congenital infection;Cytomegalovirus;Cytomegalovirus Infections;Data;Developed Countries;Development;Disease;Dose;Drug Interactions;Drug Kinetics;efficacy study;Enrollment;Esters;Evaluation;experience;Foscarnet;Funding;Future;Ganciclovir;Growth;Hearing;Hematopoietic Stem Cell Transplantation;Hepatitis C;HIV;improved;in utero;Infant;Infection;intravenous administration;Licensing;Life;Live Birth;Mental Retardation;neonatal infection;neonate;Neurologic Deficit;Newborn Infant;non-genetic;novel;Oral;Outcome;Patients;Perinatal Infection;Pharmaceutical Preparations;Phase;phase I trial;Physicians;Prophylactic treatment;Rare Diseases;Regimen;Safety;safety assessment;Secure;Sensorineural Hearing Loss;Serious Adverse Event;seropositive;standard of care;symptom treatment;Toxic effect;treatment duration;trial readiness;United States Food and Drug Administration;United States National Institutes of Health;Valganciclovir;Valine;Viral

PROJECT_TITLE: Letermovir Phase I Trial


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sexually Transmitted Infections

PI_NAMEs: WHITLEY, RICHARD J. (contact)

PROJECT_TERMS: Address;Alabama;Area;Benchmarking;burden of illness;Childhood;Clinical Research;Clinical Treatment;clinical trial readiness;Collaborations;congenital cytomegalovirus;Congenital herpes simplex;congenital infection;Data;design;Diagnosis;Disease;drug discovery;Eligibility Determination;Ensure;Enterovirus;Faculty;Financial Support;Funding;Herpes Simplex Infections;improved;Individual;Infrastructure;innovation;Institution;interest;Investments;Knowledge;Letters;Mentors;Mission;Movement;multidisciplinary;Neonatal;Parechovirus;Peer Review;Perinatal Infection;Pilot Projects;Process;programs;Rare Diseases;Request for Applications;Research;Research Personnel;Research Project Grants;Sepsis;Site;Stress;success;timeline;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: Pilot and Feasibility Core


PI_NAMEs: MUGAVERO, MICHAEL J (contact)

PROJECT_TERMS: Academy;Active Learning;base;career;career development;Clinical;clinical center;Clinical Competence;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;Communicable Diseases;Communication;Communities;Competence;Complement;congenital cytomegalovirus;Congenital herpes simplex;congenital infection;Contracts;Critiques;Development;Disease;Educational Activities;Eligibility Determination;Enterovirus;Ethics;experience;externship;Faculty;Fostering;Funding;Goals;Grant;Growth;Herpes Simplex Infections;Individual;Industry;Information Dissemination;innovation;Institution;Investigation;Journals;Knowledge;Leadership;Medicine;meetings;Mentors;Methodology;National Center for Advancing Translational Sciences;Neonatal;next generation;Parechovirus;Patients;Pediatric cohort;Peer Review;Perinatal Infection;pharmacometrics;professor;programs;Publications;Publishing;Rare Diseases;recruit;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;sabbatical;Science;Sepsis;skills;stakeholder perspectives;success;Training;training opportunity;Training Programs;Translational Research;translational scientist;Writing

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Heart Disease;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: 8. Project Narrative . Cardiac arrest is a common and devastating cardiac and neurological emergency affecting almost 400,000 victims in the US every year, many of whom are successfully resuscitated but then die in the hospital or are left with severe disability from injury to the brain during the cardiac arrest. Immediate temperature control and cooling of comatose survivors of cardiac arrest is now commonly used to try to reduce the brain injury, but it remains uncertain whether it is truly effective, how long a survivor of cardiac arrest should be cooled, and which patients are more likely to benefit. This clinical trial proposes to first determine whether longer durations of cooling improve recovery better than shorter durations, and secondly to determine the best duration of cooling, in comatose patients resuscitated from either of two different types of cardiac arrest.

PI_NAMEs: GEOCADIN, ROMERGRYKO ;MEURER, WILLIAM JOSEPH (contact);SILBERGLEIT, ROBERT

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Accident and Emergency department;Adult;Adverse event;Affect;Assessment tool;Brain;Brain Injuries;Cardiac;Cardiopulmonary Resuscitation;Categories;Cerebral Ischemia;Cessation of life;Clinical;clinical investigation;clinical practice;Clinical Trials;Coma;Data;Development;Devices;disability;Dose;Emergency Situation;Enrollment;Evaluation;Goals;Guidelines;Heart;Heart Arrest;Hospitals;improved;improved outcome;Infrastructure;Injury;innovation;Left;Link;Methods;natural hypothermia;Neurologic;Neurological emergencies;Neurological outcome;neurological recovery;Neuropsychology;out-of-hospital cardiac arrest;Outcome;Outcome Assessment;patient population;Patient Selection;Patient-Focused Outcomes;Patients;Performance;Population;pre-clinical;Quality of life;Randomized;Recommendation;Recovery;Reporting;Resources;response;Safety;Selection Criteria;Survivors;Talents;Temperature;Therapeutic;treatment effect;United States National Institutes of Health

PROJECT_TITLE: 1/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest Patients

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Diabetes;Genetics;Pediatric;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Recent data suggest that first-degree relatives of patients with T1D have a smaller pancreas than control subjects, including those without islet- autoantibodies. This application proposes a collaborative, multicenter TrialNet study of relative pancreas volume and morphological changes using noninvasive radiology with correlations to β-cell and acinar cell functions and genotype. The data and analyses emanating from this multicenter study have the potential to greatly improve our understanding of the endocrine-exocrine interactions during the natural history of T1D and may thus change the way we view T1D pathogenesis, which in turn, will impact our ability to affect clinical intervention of this disease.

PI_NAMEs: CAMPBELL-THOMPSON, MARTHA  (contact);HALLER, MICHAEL JAMES

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Abdomen;Acinar Cell;Acute;Affect;Age;Area Under Curve;Arginine;Autoantibodies;autoimmune pathogenesis;Autoimmunity;Beta Cell;Biological Markers;Blinded;Body mass index;Body Size;Body Weight;C-Peptide;Cell Physiology;Child;Chronic;Clinical;Complex;Custom;Data;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;Disease Progression;disorder risk;DNA;Early identification;Endocrine;Enrollment;Event;Fasting;First Degree Relative;Florida;Functional disorder;functional loss;Funding;genetic analysis;Genetic Determinism;Genotype;Glucose;Glycosylated hemoglobin A;Heterogeneity;high risk;Hyperglycemia;Image;Immunologics;improved;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;islet;islet cell antibody;Islets of Langerhans;Learning;lifetime risk;Lipase;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Metabolic;Morphology;MRI Scans;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;OGTT;Organ Donor;Organ Size;Organ Weight;Pancreas;Patients;Persons;Phenotype;Physiological;Prevention strategy;prognostic value;progression risk;radiologist;Radiology Specialty;Research Institute;response;Risk;Sampling;Secretory Cell;Series;Serum;sex;Structure of beta Cell of islet;Surrogate Markers;Testing;Time;Trypsinogen;United States National Institutes of Health;Universities;Weight

PROJECT_TITLE: Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Vanderbilt Oncology Training Program (VOLT) is designed to prepare trainees for an oncology career conducting cutting-edge research in basic, clinical, translational and population science. The program provides a personalized and mentored research experience with scholarly activity, focusing on developing key fundamental skills and the importance and incorporation of diversity, equity, and inclusion and community outreach and engagement.

PI_NAMEs: FRIEDMAN, DEBRA L.;JOHNSON, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Oncology;Training Programs

PROJECT_TITLE: VOLT (Vanderbilt Oncology Training Program)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Natural Products

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative: The identification of new antibiotics with activity against multidrug-resistant pathogens is currently a critical unmet medical need. Although many discovery programs deprioritized natural products as a source of new antibiotics due to high rediscovery rates, it is now clear that the global microbiome encodes a very large, previously inaccessible, reservoir of novel natural products that can serve as starting points for the development of new antibiotics. The work described here is designed to continue our development of methods for accessing novel natural products from soil metagenomes and increasingly focus on applying these methods to the discovery of new bioactive natural products, in particular, new antibiotics with activity against multidrug- resistant pathogens.

PI_NAMEs: BRADY, SEAN F (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Antibiotics;Bacteria;Bacterial natural products;Base Sequence;bioactive natural products;Bioinformatics;clinically relevant;Cloning;Culture-independent methods;design;Development;Disease;DNA;Drug Screening;Environment;Gene Cluster;Genomics;Goals;Industrialization;Laboratories;Lead;Left;Medical;metagenome;Metagenomics;method development;Methods;microbiome;Multi-Drug Resistance;multi-drug resistant pathogen;Natural History;Natural product discovery;Natural Products;Nature;novel;novel therapeutics;pathogen;Productivity;programs;Recording of previous events;Research;Sampling;screening;small molecule;Soil;Source;Structure;success;Surface;Work

PROJECT_TITLE: Discovery of Antibiotics from Soil Microbiomes Using Metagenomics

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: GODX, INC.

ORG_STATE: WI

PHR: Project Narrative Diarrheal disease is the second leading cause of death in children under 5 years of age globally, with children under five years age of age in low income countries (LICs) bearing the greatest disease burden. The purpose of this project is to develop a novel, simple, easy-to-use and affordable, paper strip tool for the identification of pathogens that cause diarrheal disease in LICs to help guide appropriate treatment.

PI_NAMEs: BAKER, KELLY K;KIM, CHANG HEE  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: 5 year old;Age;amplification detection;Antibiotics;Bangladesh;Bangladeshi;biobank;Biological Assay;burden of illness;Campylobacter;Campylobacter jejuni;Cause of Death;Cessation of life;Child;Cholera;Clinic;Clinical;co-infection;cost;cost effective;cost efficient;Death Rate;design;Detection;detection limit;detection test;Deterioration;Development;Devices;Diagnostic;diagnostic assay;Diagnostic tests;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;DNA;Dysentery;emerging pathogen;enteric pathogen;Etiology;Evaluation;expedited review;Feces;Freezing;Gastroenteritis;gastrointestinal;Gastrointestinal Diseases;Goals;Government;Health;health care service utilization;health care settings;Hospitals;improved;Infection;innovation;instrumentation;Knowledge;Laboratories;Low income;low income country;Low Income Population;Measures;Methods;Microbiology;Microspheres;Molecular;Neighborhoods;novel;nucleic acid detection;Nucleic Acid Probes;Nucleic Acids;Outcome;Paper;participant enrollment;pathogen;Patients;Phase;point of care;Preparation;Prevalence;Public Health;Quality of Care;Records;Refugees;Reproducibility;Resources;RNA;rural area;Salmonella;Salmonella enterica;Sampling;Sensitivity and Specificity;Shigella;Shigella flexneri;Shigella sonnei;Silicon Dioxide;Specificity;stool sample;success;System;test strip;Testing;Time;tool;treatment center;Validation;Vibrio cholerae;Viral;virology;World Health Organization

PROJECT_TITLE: Rapid and Simple Paper Diagnostic Test to Detect Enteric Pathogens in the Developing World

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: NARRATIVE Our studies are focusing on a recently discovered pathway of innate immunity called the “Complosome” that is present inside of most, if not all, cells. Because it is so new, we are addressing fundamental questions about who are the key players, what are their functions and how is this system disrupted by disease (as in autoimmunity and cancer). Such knowledge is likely to lead to increased understanding of undesirable inflammatory responses and identification of novel therapeutic targets.

PI_NAMEs: ATKINSON, JOHN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Autoimmunity;Biological Assay;Biological Models;Body System;Cancer Center;cancer immunotherapy;cancer type;CD46 Antigen;cell injury;Cell Separation;cell type;Cells;Collaborations;Complement;Complement Activation;Complement Inactivators;complement system;Disease;Docking;Endothelial Cells;Epithelium;flexibility;Functional disorder;Goals;Grant;Homeostasis;Human;Human Cell Line;human disease;Immune;in vitro Model;Individual;Infection;Inflammatory Response;Injury;innovation;insight;Ischemia;Knowledge;knowledgebase;Lung Transplantation;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Modeling;mouse model;Multiple Myeloma;Natural Immunity;new therapeutic target;Oncology;Oncolytic viruses;overexpression;Pathway interactions;peripheral blood;Phagocytes;Population;Positioning Attribute;Process;Proteins;Publishing;receptor;Research;response;RNA;Role;Signal Transduction;Structure of parenchyma of lung;System;Talents;targeted treatment;Tissue Donors;Tissues;tumor;uptake

PROJECT_TITLE: Defining the Complosome in Human Cells, Tissues and Disease States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: In this project we will assess how temperature impacts selective and stochastic alterations to WNV populations during systemic mosquito infection. We also will explore how virus particle aggregates and infection of individual cells by multiple WNV genotypes may influence the amount and type of genetic diversity that is maintained in the virus population. This project leverages over 15 years’ worth of WNV and ZIKV research and makes innovative use of new molecular tools that we have developed as part of this project.

PI_NAMEs: EBEL, GREGORY DAVID (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Address;Alpha Virus;analytical tool;Antibodies;Arboviruses;arthropod-borne;Bar Codes;Biology;Biometry;Birds;Cells;Chikungunya virus;Collaborations;Competence;Crows;Culex (Genus);Culicidae;Data;Disease;Disease Outbreaks;Ecology;Environment;environmental change;Evolution;experience;Face;Feasibility Studies;fitness;Flaviviridae;Flavivirus;Flavivirus Infections;Flow Cytometry;Funding;Future;Genetic Variation;Genome;Genotype;Geography;Goals;Health;Human;Humanities;Incubated;Individual;Infection;innovation;Insecticide Resistance;Knowledge;land use;Literature;Maintenance;Medicine;Midgut;Molecular;Molecular Biology;multidisciplinary;mutant;Natural Selections;Nature;novel;Nucleotides;Phase;Population;Population Biology;Population Genetics;Population Heterogeneity;Predisposition;prevent;Public Health;Research;Research Personnel;RNA Sequences;RNA Viruses;Robin bird;Role;Salivary Glands;Shapes;System;Temperature;Testing;theories;Time;Togaviridae;tool;transmission process;Urbanization;Vaccines;Variant;vector;vector competence;vector mosquito;Vertebrates;viral fitness;Viremia;Virion;virology;Virus;virus genetics;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Arbovirus population biology: temperature impacts on selection and collective dynamics

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Dementia;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

PHR: PROJECT NARRATIVE Many intensive care unit survivors suffer from pervasive cognitive impairment. While the causative mechanisms that lead to abrupt cognitive impairment are unclear, recent studies show that lung vascular endothelium produces cytotoxins after hospital-acquired bacterial infection. This application tests the hypothesis that the pulmonary endothelium-derived cytotoxins include pathological Aβ and ?  species in bacterial pneumonia-positive and critically ill patients.

PI_NAMEs: LIN, MIKE T (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: abeta deposition;abeta oligomer;acronyms;Address;Amyloid;Amyloid beta-Protein;Amyloidosis;Animals;Antibodies;Bacteria;Bacterial Infections;Bacterial Pneumonia;Blood capillaries;Blood Vessels;Brain;brain cell;brain dysfunction;Brain Injuries;brain parenchyma;Bronchoalveolar Lavage Fluid;Cerebral Ventricles;Cerebrospinal Fluid;cerebrovascular;Characteristics;Chemosensitization;Circulation;Clinical;Cognitive deficits;cognitive function;cognitive testing;Contracts;coronavirus pandemic;Critical Care;Critical Illness;cytotoxic;cytotoxicity;Cytotoxin;Delirium;Dendritic Spines;density;design;disease transmission;Endothelial Cells;Endothelium;ESKAPE pathogens;Exposure to;follow-up;Functional disorder;Generations;Health;high risk;hippocampal pyramidal neuron;Hippocampus;Hospitals;Impaired cognition;Impairment;In Situ;In Vitro;in vivo;Incubated;Induced Neurons;Infection;Injury;Intensive Care Units;Invaded;Journals;Klebsiella pneumoniae;Learning;Long-Term Potentiation;Lung;Lung infections;Mediating;Microtubules;Molecular;Molecular Weight;Multi-site clinical study;Mus;Neurologic;Neurons;neurotoxic;neurotropic;Nosocomial pneumonia;novel;Organ;pathogen;Pathologic;Patients;Peripheral;Phosphorylation;Plasma;Pneumonia;prion-like;Production;Protein Isoforms;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;Public Health;repaired;Reporting;response;Rodent;Slice;Specimen;Staphylococcus aureus;Survivors;Synapses;Tail;tau aggregation;tau expression;tau Proteins;Testing;Type III Secretion System Pathway;vascular bed;Vascular Endothelium;Veins;Vertebral column;Viral;Viral Pneumonia;Virulence;Virulent;web site;Work

PROJECT_TITLE: Nosocomial pneumonias impair cognitive function

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: TUCSON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Health relevance: Despite forty years of research on language impairments in children, information on effective treatment is sparse. The proposed studies evaluate treatment methods for vocabulary and morphosyntax deficits. The results should yield treatment procedures that can be imported into clinical practice.

PI_NAMEs: ALT, MARY ;PLANTE, ELENA M (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 3 year old;Address;Adult;Age;alternative treatment;Basic Science;Child;clinical practice;Early Intervention;economic outcome;Economics;Education;effective therapy;Expenditure;experience;experimental study;Face;Failure;Family;Fathers;Friendships;Generations;Goals;Grant;Health;improved;insight;Justice;Knowledge;Language;Language Development;Language Development Disorders;Language Disorders;language impairment;Language Therapy;Laws;Learning;literacy;Literature;Mental Health;Methods;Nature;Nursery Schools;Occupations;Outcome;Outcome Study;Parents;peer;Population;Preschool Child;Procedures;Publishing;Research;Rice;Schools;Semantics;Series;skills;Societies;socioeconomics;Special Education;statistical learning;statistics;Structure;success;System;Testing;Time;Training;Translating;treatment effect;Treatment Efficacy;Treatment Factor;Treatment outcome;treatment research;Victimization;Vocabulary;Work

PROJECT_TITLE: Identification of treatment parameters that maximize language treatment efficacy for children.

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Physical Rehabilitation;Rare Diseases;Rehabilitation;Tuberculosis

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Despite successful treatment, tuberculosis is associated with chronic lung impairment. The TB PuRe study will assess effectiveness, feasibility, and cost-effectiveness of a home-based pulmonary rehabilitation program for preventing post-tuberculosis respiratory morbidity in India.

PI_NAMEs: GOLUB, JONATHAN E. (contact);GUPTE, AKSHAY NITIN

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Aerobic;arm;Behavioral;budget impact;Characteristics;Chronic;Chronic lung disease;Client;Clinic;Clinic Visits;Clinical;comparative effectiveness;Controlled Clinical Trials;cost;cost comparison;cost effective intervention;cost effectiveness;Counseling;Data;design;Development;Disease;drug-sensitive;Education;effective intervention;effectiveness evaluation;effectiveness measure;effectiveness outcome;effectiveness study;Eligibility Determination;Enrollment;Ensure;Epidemiology;EuroQOL;Excess Mortality;exercise capacity;Functional impairment;functional status;Funding;Geography;Goals;Health;health care service utilization;health related quality of life;Health system;Home;impaired functional status;Impairment;implementation/effectiveness;improved;India;Individual;Infrastructure;Intervention;intervention delivery;Interview;Lung;Lung Diseases;lung health;lung injury;Measures;Monitor;Morbidity - disease rate;mortality risk;multidisciplinary;Natural History;Nature;Nutritional;Outcome Assessment;Participant;Patient-Focused Outcomes;Patients;Population;prevent;primary outcome;Process;programs;Public Health;pulmonary function;pulmonary rehabilitation;Pulmonary Tuberculosis;Randomized;rehabilitation strategy;Research;Resistance;Resource-limited setting;Resources;respiratory health;respiratory morbidity;scale up;secondary outcome;service delivery;service organization;Site;societal costs;standard of care;success;Survivors;Target Populations;telephone coaching;Testing;three-arm study;Training;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Walking

PROJECT_TITLE: TB PuRe : Pulmonary rehabilitation to reduce post-tuberculosis morbidity

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: Project Narrative The goal of this project is to develop tools for analyzing data from intense X-ray sources in order to obtain information concerning the structure of muscle. By understanding how muscle works, and how it is controlled, it is possible to determine changes to muscle structure and performance due to genetic changes associated with inherited muscle diseases, including heart diseases. Such understanding can provide clues as to how to treat these diseases.

PI_NAMEs: IRVING, THOMAS C (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Address;Adoption;Algorithms;Animal Model;Area;Artificial Intelligence;base;beamline;Biophysics;Biopsy;Cardiomyopathies;Center Core Grants;Code;Communities;Computer Simulation;Computer software;computerized tools;connectin;Contracts;Data;Data Analyses;data reduction;Data Set;data tools;deep learning;detector;Development;Diffuse;Disease;Documentation;electron density;experimental study;Fiber;Funding;Future;Generations;Goals;Grant;Heart Diseases;Human;improved;indexing;Inherited;Laboratories;Methodology;Methods;Microfilaments;millisecond;Modeling;Molecular;Muscle;Muscle Fibers;Muscle function;muscular structure;muscular system;Mutation;Myopathy;Myosin ATPase;myosin-binding protein C;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of General Medical Sciences;nebulin;novel;novel strategies;Pattern;Performance;Persons;Phenotype;Photons;Physiological;Positioning Attribute;pre-clinical;predictive tools;Procedures;Production;Productivity;programs;Property;Publishing;Regulation;Reproducibility;Resolution;Resources;Roentgen Rays;Sarcomeres;simulation;Skeletal Muscle;software development;Source;Striated Muscles;Structure;Synchrotrons;Techniques;Technology;Testing;Thick Filament;Thin Filament;Time;tool;Training;two-dimensional;user-friendly;Validation;Work;X ray diffraction analysis

PROJECT_TITLE: Analysis Tools for Fiber Diffraction of Muscle

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SWARTHMORE

ORG_NAME: SWARTHMORE COLLEGE

PHR: Project Narrative: Acute chemical exposure to organophosphorus compounds arising from terrorist attacks or accidental poisonings pose a serious threat to human health, but current treatment strategies are not suitable for administering to large civilian populations. The goal of this research is to develop a cost-effective organismal platform using planarians for screening of possible therapeutics for treatment of acute toxicity induced by organophosphorus compounds. Cost-effective, rapid screening platforms, such as the one developed here, promise to accelerate the discovery of new therapeutics to better prevent against mass casualties.

PI_NAMEs: COLLINS, EVA-MARIA SCHOETZ (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acceleration;Accidents;Acetylcholine;Acetylcholinesterase;Acute;acute symptom;acute toxicity;Adopted;Adult;Adverse effects;Aftercare;Age;Animals;Anticonvulsants;Atropine;Behavior;Behavioral;Biological Assay;Brain Death;Brain Injuries;Butyrylcholinesterase;Carbamates;Characteristics;Chemical Exposure;Chemicals;cholinergic;Cholinesterases;Chronic;Comparative Study;Complex;cost;cost effective;Data;Development;Dose;effective therapy;Enzyme Inhibition;Enzymes;Epilepsy;Exposure to;fluorophosphate;Glutamate Agonist;Glutamate Receptor;Goals;Health;high throughput screening;Hour;Human;improved;In Vitro;Individual;Industrial Accidents;Invertebrates;knock-down;Length;Life;Mammals;mass casualty;Measures;Medical;Metabolic;meter;Methods;Midazolam;Morphology;mortality;Muscarinic Acetylcholine Receptor;N-Methylaspartate;nerve gas;neuronal circuitry;Neurotoxins;Nicotinic Receptors;novel;novel therapeutics;Organism;Organophosphorus Compounds;Oximes;Parathion;pesticide exposure;pesticide poisoning;Pesticides;Pharmaceutical Preparations;Phenotype;Physostigmine;Planarians;Platyhelminths;Poisoning;Population;prevent;Proteins;Rapid screening;reduce symptoms;Research;Respiratory distress;Robotics;screening;Screening procedure;Seizures;Status Epilepticus;Survival Rate;Symptoms;System;Terrorism;Testing;Therapeutic;therapeutic candidate;therapeutic evaluation;Therapeutic Uses;Time;Toxic effect;toxicant;treatment strategy;Unconscious State

PROJECT_TITLE: Novel behavioral screening tool for therapeutics against organophosphorus agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: ATHENS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will (1) improve the safety of concussed individuals and the general population that use roadways, (2) guide the practices of health professionals, and (3) substantiate the work of policy-makers by providing strong evidence-based recommendations for managing post-concussion driving. This translational study is relevant to the mission of both the NIH and NINDS because it provides fundamental knowledge about how brain injury burdens concussed drivers, while also identifying which widely used clinical outcomes are associated with post-concussion driving impairment.

PI_NAMEs: SCHMIDT, JULIANNE D (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accidents;Acute;Address;Age;Automobile Driving;Brain Concussion;Brain Injuries;Caring;Clinical;Clinical assessments;clinical predictors;clinically relevant;cognitive skill;college;Communities;comparison control;Data;driving performance;driving safety;Equilibrium;evidence base;evidence based guidelines;executive function;Exhibits;Feeling;Freedom;Frequencies;Fright;Functional impairment;Funding;Future;Gait;General Population;Global Positioning System;Goals;Health Professional;Hour;impaired driving performance;Impairment;improved;Incidence;Individual;Injury;injury burden;innovation;Knowledge;Lateral;Measures;Medical;medical attention;Memory;mild traumatic brain injury;Mission;Motor;Motor Skills;National Institute of Neurological Disorders and Stroke;Neurocognition;Neurocognitive;Outcome;Outcome Assessment;outcome prediction;Participant;Patients;Policy Maker;Positioning Attribute;processing speed;psychosocial;Public Health;Publishing;Readiness;Recommendation;Recovery;Reporting;Research;Research Personnel;Risk;Risk Factors;Safety;Sampling;Speed;Symptoms;Time;translational study;United States;United States National Institutes of Health;unsafe driving;Vehicle crash;Visual;Work;young adult

PROJECT_TITLE: Longitudinal Assessment of Post-concussion Driving in Young Adults (LAPDYA)

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: JOHNSON CITY

ORG_DEPT: SURGERY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

PHR: Narrative Candida auris is an emerging fungal pathogen that is notable for its resistance to commonly used antifungal therapy. We have discovered that C. auris contains sugar molecules on its cell surface that are unique and that are not found in other fungal pathogens. In this research we will develop a prototype C. auris vaccine based on this novel carbohydrate and we will evaluate the efficacy of the vaccine in mouse models of C. auris infection.

PI_NAMEs: WILLIAMS, DAVID L. (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acids;adaptive immune response;Address;Adjuvant;anti-fungal agents;Antifungal Therapy;Awareness;B-Lymphocytes;Candida;Candida albicans;Candida auris;Candidiasis;Carbohydrates;Cell surface;Clinical;Dangerousness;Data;Death Rate;Decontamination;Development;Disease Outbreaks;Dose;draining lymph node;Drug resistance;efficacy evaluation;Emerging Communicable Diseases;Environment;Exhibits;Fluconazole resistance;Formulation;Foundations;Fungal Drug Resistance;Future;Genetic Transcription;Goals;Health Personnel;Healthcare;Hospitals;Immune;Immunity;immunological status;Immunologics;Infection;Innate Immune Response;inorganic phosphate;Literature;Mannans;Morbidity - disease rate;mortality;mouse model;Mus;novel;Nursing Homes;organ injury;pathogen;pathogenic fungus;Patients;Persons;Phagocytes;Phenotype;prevent;Prevention;Protocols documentation;prototype;Public Health;Reagent;Reporting;Research;Resistance;resistant strain;response;Side;Skin;Skin colonization;Structure;sugar;Surface;T-Lymphocyte;Time;transmission process;Vaccination;vaccine development;vaccine efficacy;vaccine formulation;vaccine immunogenicity;Vaccines;virtual

PROJECT_TITLE: Development of an alpha-1 phosphate mannan vaccine against the emerging fungal pathogen Candida auris.

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Pediatric;Precision Medicine;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Risk of smoking cigarettes depends on interactions between environmental factors, age, and genetics. This project uses advanced long-read genome sequencing and unbiased pangenomic analysis to fully identify genetic variants in the hybrid rat diversity panel. Combined with nicotine self-administration data from this panel, our ad- vanced systems genetics approach will define causal linkages between DNA variants and key nicotine-dependent behaviors including initial acquisition and motivation to take nicotine, withdrawal from nicotine dependence, and nicotine seeking under conditions that model aspects of human relapse to smoking.

PI_NAMEs: CHEN, HAO ;SHARP, BURT M (contact);WILLIAMS, ROBERT W.

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Abstinence;addiction;Address;Adolescence;Adolescent;Adult;advanced system;Age;Area;Automobile Driving;base;Behavior;Behavioral;behavioral phenotyping;Biological Sciences;Brain;Candidate Disease Gene;candidate identification;causal model;Chromosome Mapping;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoke;cigarette smoking;cofactor;comorbidity;Complex;contig;Cues;dark matter;Darkness;Data;data structure;Dependence;Development;Disease;Distant;DNA;Dose;Drug abuse;Drug Exposure;Drug Interactions;early adolescence;Environment;Environmental Risk Factor;Etiology;experience;Experimental Designs;Female;Future;gene network;Genes;Genetic;genetic analysis;genetic approach;genetic architecture;genetic information;Genetic study;genetic variant;Genetic Variation;Genome;genome resource;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Health;Heritability;Human;Human Genome;human model;Hybrids;improved;Inbred Strain;Inbreeding;Individual;individual variation;innovation;insertion/deletion mutation;insight;Intake;Intravenous;Investigation;male;Malignant Neoplasms;Maps;metabolomics;Metadata;Methods;Modeling;Molecular;Molecular Genetics;molecular phenotype;Moon;motivated behavior;Motivation;nanopore;National Institute of Drug Abuse;neural;neurochemistry;Nicotine;nicotine abuse;Nicotine Dependence;nicotine seeking behavior;nicotine self-administration;Nicotine Withdrawal;novel;Outcome;pan-genome;Parents;personalized medicine;Pharmaceutical Preparations;Phase;phenome;Phenotype;Play;Population;precision medicine;preventable death;Proteomics;Psychological reinforcement;Psychotropic Drugs;Quantitative Trait Loci;rat genome;Rat Strains;Rattus;reference genome;Reference Standards;Relapse;Reporting;Resources;response;Risk;Role;Sampling;Self Administration;Severities;sex;Side;Single Nucleotide Polymorphism;Smoking;Smoking treatment;Structure;Surgeon;System;Technology;telomere;Tobacco smoke;tool;trait;transcriptomics;Variant;variant detection;Vulnerable Populations;Withdrawal

PROJECT_TITLE: Pangenomics of nicotine abuse in the hybrid rat diversity panel


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Consuming a health-promoting diet is out of reach for many Americans, and disproportionately so for low- income and minoritized populations. This study will assess the short- and long-term impacts on cardiometabolic risk factors and implementation equity of an innovative fruit and vegetable incentive program to address structural barriers to healthy eating.

PI_NAMEs: BAQUERO, BARBARA I;JONES-SMITH, JESSICA C (contact);KNOX, MELISSA A.

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: access disparities;Address;Affect;American;beneficiary;Black Populations;Black race;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular risk factor;Cessation of life;cohort;community partners;comparison group;Consumption;cost;Data;design;Diet;dietary;Disparity;Eating;Economic Factors;Economics;Electronic Health Record;Eligibility Determination;Employment;Enrollment;Equity;Ethnic Origin;Exclusion;experience;Family member;farmers markets;Federal Government;Feeling;financial incentive;Food;food insecurity;food security;fruits and vegetables;Health;Health Food;health inequalities;Health Promotion;health record;Healthy Eating;high risk;High-Income Populations;Hour;Household;Immigrant;Impact evaluation;improved;incentive program;Incentives;Income;Inequity;innovation;Intake;Intervention;Language;Latinx;Latinx population;Low income;Low Income Population;Marketing;Methodology;Methods;Minority Groups;mortality;Municipalities;Neighborhoods;operation;Outcome;Outcome Study;Participant;people of color;Persons;Play;Policies;Policy Maker;Population;Poverty;Price;programs;Qualifying;Quasi-experiment;Race;Racial Equity;racial identity;Randomized;Risk Factors;Sample Size;Services;socioeconomics;Source;Spatial Distribution;structural determinants;Structural Racism;Supermarket;systemic barrier;usability;Waiting Lists;Work

PROJECT_TITLE: The FRESH Study: The Fresh Bucks racial equity, socioeconomic & health outcomes study

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

ORG_CITY: CLEMSON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Allowing the use of low frame rate videos for cell tracking will enable researchers to study cell dynamics at scale, multiplying the number of experimental treatments tracked concurrently, and reducing the number of experimental artifacts generated. This proposal focuses on cell displacement prediction to overcome the limitations of current cell tracking approaches. Given the importance of studying cell dynamics, the results of our research will have very broad applicability in many areas of biomedical science, including developmental biology, drug discovery, and regenerative medicine.

PI_NAMEs: IURICICH, FEDERICO  (contact)

PROJECT_TERMS: A549;Address;Affect;Air;Algorithms;Area;Biochemistry;Bioinformatics;Biological;Biology;cell analyzer;cell motility;Cell Nucleus;cell type;Cells;Cellular biology;cellular imaging;Cessation of life;Classification;Clover;Consumption;cost;cytate;cytotoxicity;Data;Data Set;deep learning;deep neural network;design;Developmental Biology;Drops;drug discovery;Environment;Equipment;Evaluation;Event;Formulation;Future;Genetic;Health;HL60;Hour;Image;improved;innovation;interest;Learning;light transmission;Link;live cell imaging;Locomotion;Machine Learning;Mammalian Cell;Manuals;MCF10A cells;MDA MB 231;Measures;Medicine;Membrane;Methods;Microscope;Morphologic artifacts;Morphology;Movement;neural network;novel strategies;Performance;Photobleaching;Phototoxicity;Preparation;recurrent neural network;Regenerative Medicine;Research;Research Personnel;Resources;Science;Speed;Techniques;Temperature;Testing;Time;tool;Training;Visualization;Work

PROJECT_TITLE: Cell tracking in low-frame-rate video based on displacement prediction

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]