NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact)

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immunity;Africa;Animal Model;Arenavirus;Automobile Driving;Bioinformatics;Biological Markers;Case Fatality Rates;Case Study;Catalogs;Cells;Central Africa;Cessation of life;Clinical;clinical predictive model;Communicable Diseases;Complement;Complex;Coronavirus;COVID-19;COVID-19 morbidity;COVID-19 pandemic;Data;data integration;data management;Data Set;Demographic Factors;Development;Disease;Disease Outbreaks;Disease Outcome;Ebola;Ebola virus;Environmental Risk Factor;Epidemiology;Evolution;Exposure to;Filovirus;Generations;Genetic;Genomics;Goals;Human;human disease;Immune;Immune response;Immunity;Individual;Infection;Investigation;Lassa;Lassa virus;long-term sequelae;Modeling;Molecular;Molecular Epidemiology;Monoclonal Antibodies;multiple omics;Mutation;Nigeria;open source;Outcome;pathogen;Patients;Play;predictive modeling;Process;Research;response;Role;SARS-CoV-2 infection;Seasons;Serology;Seroprevalences;Severe Acute Respiratory Syndrome;Severities;Severity of illness;Sierra Leone;single cell sequencing;System;Systems Biology;Techniques;technological innovation;Technology;Testing;transcriptomics;Vaccinated;Vaccination;Validation;Variant;variants of concern;Viral;Viral Genome;Viral Hemorrhagic Fevers;Virulence;Virus;Virus Diseases;virus genetics;Work

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: SEDIVY, JOHN M (contact)

PROJECT_TERMS: age related chronic disease;age-related disease;Aging;aging mechanism;aging process;Alzheimer's Disease;Applications Grants;Attention;Biology;Cell Line;Central Nervous System;Collaborations;Communication;Communities;Complementary DNA;conflict resolution;Consensus;Cytoplasm;Data Set;data submission;Databases;Dementia;Deposition;derepression;design;Development;DNA Damage;Ensure;Evaluation Research;Genome;Goals;hallmarks of aging;high standard;Host Defense Mechanism;Inflammaging;Inflammation;Information Dissemination;inhibitor therapy;Innate Immune System;Insertional Mutagenesis;Institution;Interferon Type I;Joints;L1 Elements;Lead;Leadership;Mediation;meetings;member;Mentors;Modeling;Molecular;Monitor;mouse model;Nerve Degeneration;Neurodegenerative Disorders;new technology;novel;Nucleosides;programs;Progress Reports;Protocols documentation;public database;Publications;Reagent;Recommendation;recruit;Regulation;Repetitive Sequence;Reporter;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;response;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Role;Services;Site;Sterility;Technology;tool;Training;Transcript;translational potential;United States National Institutes of Health;videoconference;Writing

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: CLEMSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative This proposal will develop a dynamic simulation modeling framework for surveillance, prediction, and real-time allocation of essential resources to underserved communities in order to reduce health disparities during Covid-19 and future pandemics. Our flexible modeling framework will integrate real-time data on infectious disease outcomes with individual and community level contextual factors to inform infectious disease surveillance and improve understanding of disease epidemiology in underserved communities, and to support the decision-making process for resource allocation to high-risk populations. In collaboration with public health decision-makers, we will utilize our toolkit to inform real-time scheduling of South Carolina’s fleet of Covid-19 mobile vaccination clinics to underserved communities across the state; this has potential to save countless lives during the Covid-19 pandemic and will lay the foundation for effective resource allocation to underserved communities in other health emergencies.

PI_NAMEs: RENNERT, LIOR  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Address;Age;age related;American;barrier to care;Black American;Cessation of life;Characteristics;Clinic;Clinical;Collaborations;Collection;Communicable Diseases;Communities;Complex;contextual factors;coping;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;COVID-19 testing;COVID-19 vaccination;COVID-19 vaccine;Data;Data Sources;Databases;Decision Making;Development;Disease;Disease Outcome;Disease Surveillance;disease transmission;Disparity;economic disparity;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;Epidemiology;flexibility;Foundations;Future;future pandemic;Geographic Locations;Goals;Health;health disparity;health inequalities;Health Services Accessibility;Health system;high risk;high risk population;Hispanic Americans;Hospitalization;improved;Individual;inequitable distribution;Inequity;Infectious Disease Epidemiology;Information Systems;Infrastructure;innovation;Intervention;intervention delivery;Knowledge;Location;Machine Learning;Measures;medically underserved;medically underserved population;mobile health clinic;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;multilevel analysis;neighborhood disadvantage;pandemic disease;pandemic preparedness;Parameter Estimation;Pathway interactions;Phase;Population;Population Surveillance;Populations at Risk;predictive modeling;prevent;Process;Public Health;Reduce health disparities;Resource Allocation;Resources;respiratory;Risk;rural Americans;SARS-CoV-2 infection;Schedule;Science;severe COVID-19;sociodemographics;socioeconomics;South Carolina;Statistical Models;Structure;Surveys;Symptoms;System;Testing;Time;tool;Translations;transmission process;underserved community;Underserved Population;Update;uptake;user-friendly;Vaccination;vaccine acceptance;vaccine effectiveness;vaccine hesitancy;Vaccines;Work

PROJECT_TITLE: Developing a dynamic modeling framework for surveillance, prediction, and real-time resource allocation to reduce health disparities during Covid-19 and future pandemics

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: MACON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: Malaria is among the deadliest infectious diseases and kills an estimated half million persons every year. This project seeks to identify vaccine epitopes that target three critical stages of parasite infection of the liver. The findings may lead to the development of a novel and improved malaria pre-erythrocytic vaccine.

PI_NAMEs: CHA, SUNG-JAE  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Antibodies;Antigen Targeting;Antigens;Binding;Biological Assay;Blood Circulation;Blood Vessels;Cd68;Cell Communication;Cell surface;Charge;chemokine;Circulation;circumsporozoite;circumsporozoite protein;Communicable Diseases;Culicidae;Development;Discontinuous Capillary;Endothelial Cells;Epitopes;Erythrocytes;Glyceraldehyde-3-Phosphate Dehydrogenases;Glycosaminoglycans;Hepatic Stellate Cell;Hepatocyte;Immunization;immunogenicity;improved;Infection;Invaded;Kupffer Cells;Libraries;Ligands;Liver;liver infection;Macrophage;Malaria;malaria infection;Malaria Vaccines;Mediating;Membrane Proteins;Mus;novel;Parasites;Parasitic infection;Peptide Phage Display Library;Peptides;Persons;Phage Display;phospholipid scramblase;Plasmodium;Plasmodium berghei;Plasmodium falciparum;preclinical evaluation;Process;protective efficacy;Proteins;receptor;Receptor Cell;Reporting;Skin;Sporozoites;stellate cell;Sterility;Surface;Testing;transcytosis;Transgenic Organisms;Vaccine Antigen;Vaccines

PROJECT_TITLE: Development of novel malaria pre-erythrocytic vaccine antigens targeting Plasmodium sporozoite liver infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: BOEKE, JEF D (contact)

PROJECT_TERMS: Affinity Chromatography;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Animals;Area;Biological;Biological Assay;Biology;Cell Aging;cell type;Cells;ChIP-seq;Clinical;Collaborations;Complementary DNA;Complex;Computer Analysis;computerized tools;Computing Methodologies;Cytoplasm;Data;Data Set;Dementia;demethylation;design;Detection;DNA;Drosophila genus;Elements;Engineering;Environment;Eukaryota;Event;fascinate;gene product;Genes;genomic locus;genomic tools;Genomics;Germ Lines;Goals;Grant;Hybrids;imaging modality;Imaging technology;improved;in vivo;Individual;insight;interest;Interphase Cell;L1 Elements;Life Cycle Stages;Maps;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;Monitor;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;novel;Organism;Participant;permissiveness;postmitotic;promoter;Property;Proteins;Proteomics;Reporter;Reporting;response;Retrotransposition;Retrotransposon;Reverse Transcription;RNA immunoprecipitation sequencing;Role;Sampling;Sequence Analysis;single cell sequencing;single molecule;single-cell RNA sequencing;Stimulator of Interferon Genes;System;technological innovation;Technology;technology validation;Tissues;tool;Transcript;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translations;Visualization;Work

PROJECT_TITLE: Core B - Retrotransposon Genomics, Technology and Analysis Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Peripheral Neuropathy

PI_NAMEs: SELUANOV, ANDREI  (contact)

PROJECT_TERMS: Affect;Age;age related;Age related pathologies;aged;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Animal Experimentation;Animal Housing;Animal Husbandry;Animals;Biological;Biological Assay;blind;Brain;Brain region;Breeding;Cell Aging;cellular pathology;Chiroptera;Cognition;cognitive performance;Collaborations;Confusion;cost;CRISPR/Cas technology;Cytoplasm;Data;Databases;DNA;Ensure;experimental study;extracellular;Funding;Gene Modified;Genes;Genomics;Genotype;Goals;Harvest;healthspan;Histologic;IACUC;improved;Individual;Inflammaging;Inflammation;inhibitor therapy;Innate Immune Response;Institution;Interferon Type II;Interferons;Intervention;Knockout Mice;L1 Elements;Life;life span;Longevity;Mediating;Modeling;Mole Rats;mouse model;Mus;Mutate;Mutation;Nerve Degeneration;Neurofibrillary Tangles;neuropathology;Neuropathy;novel;Nucleosides;old mice;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physical Performance;Program Research Project Grants;Protocols documentation;Quality Control;Reporter;Reproducibility of Results;Research Personnel;response;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Rodent;Role;Sampling;Senile Plaques;Signal Transduction;Site;small hairpin RNA;Specimen;Standardization;Sterility;Stimulator of Interferon Genes;systemic inflammatory response;Testing;Tissues;transcriptomics;Transgenic Mice;treatment effect;Universities

PROJECT_TITLE: Core C: Mouse Intervention and Neuropathy Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative: This project focuses on how RNAs are packaged into extracellular carriers to communicate with neighboring cells, using colorectal carcinoma as a model system. This research is relevant to human health because this extracellular RNA-mediated communication may be a major way to influence the tumor microenvironment and influence tumor aggressiveness.

PI_NAMEs: WEAVER, ALISSA M (contact)

PROJECT_TERMS: Affect;Automobile Driving;Behavior;Binding;Biochemical;Biogenesis;Biological Models;Cell membrane;Cells;Cellular Membrane;Ceramides;Cetuximab;Cholesterol;Code;Collecting Cell;Communication;Complex;Data;Endoplasmic Reticulum;endosome membrane;Endosomes;Engineering;Epidermal Growth Factor Receptor;Event;exosome;extracellular;extracellular vesicles;Fractionation;Gene Expression;gene function;Health;Human;In Vitro;in vivo;knock-down;KRAS2 gene;Large Intestine Carcinoma;late endosome;Link;lipid transport;Lipids;Malignant Epithelial Cell;Mediating;Membrane;Messenger RNA;Methods;MicroRNAs;microvesicles;mRNA Translation;novel;Organelles;overexpression;palmitoylation;Phenotype;Poly(A)+ RNA;Polyribosomes;protein complex;Proteins;receptor;release of sequestered calcium ion into cytoplasm;Research;Resistance;Ribosomal Proteins;Ribosomes;RNA;RNA Binding;RNA Transport;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Rough endoplasmic reticulum;Route;segregation;Signal Transduction;Site;small hairpin RNA;Small Nucleolar RNA;Testing;Tissues;trait;transcriptome sequencing;Transfer RNA;tumor;tumor growth;tumor microenvironment;tumorigenesis;ubiquitin ligase;Ubiquitination;Untranslated RNA;Vesicle

PROJECT_TITLE: Role of ER-membrane contacts in biogenesis of RNA-containing EVs


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Ablation;Address;Age;Age related macular degeneration;age related neurodegeneration;Age related pathologies;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Astrocytes;bioinformatics pipeline;Biological Assay;Biological Models;Biology;Brain;brain tissue;Cell Aging;Cell Death;cell type;Cells;Central Nervous System;Cessation of life;Chromatin;Clinical;Clinical Trials;Collaborations;Communication;Complementary DNA;Complex;Cytoplasm;derepression;Disease;DNA;DNA Damage;Down-Regulation;Elderly;Elements;experimental study;Failure;Fibroblasts;Fluorescence Microscopy;Fluorescent Probes;Funding;gene therapy;Genome;genomic locus;hallmarks of aging;Heterochromatin;Host Defense Mechanism;Human;Human Genome;human induced pluripotent stem cells;induced pluripotent stem cell;Inflammaging;Inflammation;Inflammatory;inhibitor therapy;Innate Immune System;insight;interest;Interferon Type I;Interferons;Intervention;Invaded;Knowledge;L1 Elements;Life Cycle Stages;Link;Location;Long-Term Effects;Messenger RNA;Microglia;Microscopy;mitochondrial dysfunction;Modeling;Molecular;Monitor;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;Nuclear;Nucleosides;old mice;Organism;Outcome;overexpression;particle;Paste substance;Pathologic;Pathology;Pathway interactions;Phenotype;postmitotic;Process;Proteins;pseudotoxoplasmosis syndrome;Repetitive Sequence;Research Personnel;Resolution;response;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Ribonucleoproteins;RNA;RNA-Directed DNA Polymerase;Role;senescence;senescent cell;sensor;single molecule;single nucleus RNA-sequencing;Site;Somatic Cell;stem cell model;Sterility;Stimulus;surveillance study;System;Tetanus Helper Peptide;Therapeutic;Time;Tissues;Transcript;transposon/insertion element;TREX1 gene;ultra high resolution;Up-Regulation;Virus;Visualization;Work

PROJECT_TITLE: Project 1: Activation of Alternative L1 Lifecycles in the CNS with age and Alzheimer's Disease


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Columbus

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Lenacapavir is a promising, investigational, long-acting and highly potent HIV capsid inhibitor that could complement current antiretroviral compounds to treat people living with HIV. However, cell culture-based viral breakthrough assays and ongoing clinical trials have identified substitutions in capsid that confer substantial resistance to lenacapavir. We propose to rationally modify lenacapavir to develop improved HIV capsid inhibitors with a improved potency and high barrier to resistance.

PI_NAMEs: ADU-AMPRATWUM, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Academia;analog;Anti-Retroviral Agents;Anti-viral Agents;base;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Capsid;Capsid Proteins;Cell Culture Techniques;Cells;Chemical Structure;Clinical Trials;Complement;Coupled;cytotoxicity;Data;design;Development;Dose;Drug Industry;Drug resistance;drug resistant virus;Drug Targeting;Electrostatics;experience;experimental study;follow-up;functional group;gag Gene Products;Generations;Goals;HIV;HIV resistance;HIV-1;HIV-1 drug resistance;Hydrophobicity;improved;Infection;inhibitor;Investigation;Lead;Life Cycle Stages;Modification;Multi-Drug Resistance;multimodality;novel;Patients;Persons;Pharmaceutical Chemistry;Phase II/III Clinical Trial;Phenotype;prevent;Process;Proteins;Publishing;rational design;Reagent;Research;Resistance;Resistance profile;Resolution;Roentgen Rays;Role;Scanning;Science;screening;small molecule;structural biology;Structure;Structure-Activity Relationship;subcutaneous;Surface Plasmon Resonance;Testing;Variant;Viral;Viral Physiology;virology;Virus;Virus Replication;X-Ray Crystallography

PROJECT_TITLE: Development of Improved HIV-1 Capsid Inhibitors

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


PHR: exRNA in Colorectal Carcinoma: Biogenesis and Function Project 2. Mechanisms and Functional Consequences of Selective miRNA Transfer via Exosomes Narrative Extracellular communication by RNA is a recently discovered mechanism that may underlie mechanisms explaining tumor-microenvironment interactions, metastasis, and the cancer field effect. We will investigate mechanisms regulating selective export of miRNAs and the role they play in extracellular communication during colorectal cancer.

PI_NAMEs: PATTON, JAMES G. (contact)

PROJECT_TERMS: base;Biogenesis;Biological Assay;cancer cell;Cell Communication;Cell Culture Techniques;Cell secretion;cell type;Cells;Cetuximab;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;colonic crypt;Colorectal;Colorectal Cancer;Communication;Coupled;Coupling;CRISPR/Cas technology;Data;differential expression;Epidermal Growth Factor Receptor;Epigenetic Process;exosome;extracellular;extracellular vesicles;Genes;Immunoprecipitation;In Vitro;in vivo;KRAS2 gene;Large Intestine Carcinoma;Lipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Methods;MicroRNAs;Modification;mutant;Mutation;Neoplasm Metastasis;Normal Cell;novel;Pattern;pharmacologic;Play;Proliferating;Proteins;rapid testing;Research Personnel;Resistance;RNA;RNA Sequences;RNA-Binding Proteins;Role;Signal Transduction;stem cell niche;Techniques;Testing;therapeutic target;three dimensional cell culture;transcriptome sequencing;tumor growth;tumor microenvironment;Up-Regulation;uptake;WNT Signaling Pathway;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Mechanisms and Functional Consequences of Selective miRNA transfer via extracellular vesicles


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: HELFAND, STEPHEN L (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age effect;age related;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Bioinformatics;Biological Models;Brain;brain cell;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Consumption;Development;Disease;Disease Progression;Drosophila genus;Elements;epigenome;extend lifespan;fly;Functional disorder;gene repression;gene therapy;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;healthspan;Heterochromatin;Homeostasis;Homologous Gene;Human;Inflammation;innovation;Intervention;life span;Maintenance;Mammals;Methods;Modeling;Molecular;Mus;Mutagenesis;Nerve Degeneration;Nervous System;Neuroglia;Neurons;normal aging;novel;Organism;Pathway interactions;Phenotype;Physiological;pro-aging;Proteins;Regulation;remediation;Reporter;Retrotransposon;Role;Series;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Somatic Cell;Testing;Time;tissue culture;Tissues;tool;Work

PROJECT_TITLE: Project 2: Role of Retrotransposable Element Activity in Drosophila Models of Alzheimer's Disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: The proposed technology will provide the first high-resolution imaging flow cytometry that can image small and large biological samples in three-dimensions with high-resolution. Such system will provide doctors with enhanced capabilities to diagnose patients with high accuracy and help scientists to significantly improve their research outcomes.

PI_NAMEs: BEN-YAKAR, ADELA  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;absorption;Animals;Big Data;Biological;Biological Assay;Caenorhabditis elegans;Cancer Biology;cancer cell;cancer diagnosis;Cardiac;Cardiotoxicity;cell dimension;Cells;cellular imaging;Collaborations;Color;Communities;computer infrastructure;convolutional neural network;Cytometry;Data;data acquisition;Data Analyses;Data Compression;Data Display;data handling;Data Reporting;deep learning model;Detection;detection method;Development;Diagnosis;drug discovery;Early Diagnosis;Emulsions;experimental study;Flow Cytometry;fluorescence imaging;Frequencies;Goals;heart dimension/size;Hela Cells;Hematology;high resolution imaging;high reward;high risk;human induced pluripotent stem cells;Image;imaging platform;Immersion;Immunology;improved;Individual;Infrastructure;Inherited;Label;Length;Light;Lobe;Location;Measurement;Measures;Metadata;meter;Methods;Microbiology;Microfluidic Microchips;Microscope;microscopic imaging;Microscopy;Morphologic artifacts;Morphology;Names;Nature;next generation;Noise;novel;Optics;Organoids;Outcomes Research;Pathology;Patients;Pharmaceutical Preparations;Phenotype;photomultiplier;Population;rare cancer;Resolution;Rotation;Sample Size;Sampling;Scanning;Scientist;screening;Side;Signal Transduction;Silicon;Spatial Distribution;Specimen;Speed;spheroids;Spottings;stem cell biology;submicron;System;Technology;Therapeutic;Three-Dimensional Imaging;Time;Tissue Engineering;tool;Toxic effect;Training;Translations;two photon microscopy;two-dimensional;two-photon;Visualization

PROJECT_TITLE: Three-dimensional fluorescence imaging flow cytometry at up to million frames per second

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Cervical cancer continues to cause disability and death in millions of women living in tropical regions of the world who do not have access to cervical cancer screening and human papilloma virus (HPV) vaccination. People living in tropical countries are commonly infected with intestinal worms (helminths), which can live largely undetected in their hosts by muting the immune response. Understanding the impact of helminth infection on the cervico-vaginal microenvironment may lead to the development of improved cervical cancer prevention strategies in tropical countries.

PI_NAMEs: CLARK, EVA H (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Adult women;Advisory Committees;Affect;authority;Biological;Biological Assay;Cancer Etiology;cancer risk;career;career development;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical dysplasia;cervicovaginal;cervicovaginal microbiome;Cessation of life;Childhood;Chronic;chronic infection;Clinical;Clinical Research;co-infection;college;Communicable Diseases;Communities;cost;Country;Cross-Sectional Studies;cytokine;Data;Detection;Development;Development Plans;disability;dysbiosis;Environment;Epidemiologist;Epithelial Cells;female reproductive tract;Funding;global health;Goals;Health;Health system;helminth infection;Helminths;Helper-Inducer T-Lymphocyte;high risk;High Risk Woman;HPV screening;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Immune;Immune response;Immunity;Immunization Programs;Immunologics;improved;infection risk;innovation;International;Intervention;intervention cost;Intestines;K-Series Research Career Programs;Lactobacillus;Large Intestine;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Medicine;meetings;Mentors;Mentorship;microbiome;microbiota;Molecular;novel;older women;Parasitology;Pathway interactions;Persons;Peru;Physicians;polarized cell;Population;Prevalence;prevent;Prevention strategy;professor;programs;Public Health;Regulatory T-Lymphocyte;Research;Resource-limited setting;Resources;Risk;Scientist;screening program;skills;Soil;Specimen;Structure;Swab;T cell response;Teacher Professional Development;Technology;Testing;Training;Training Activity;transmission process;treatment program;Tropical Medicine;United States National Institutes of Health;Vaccination;Vagina;Virus;Whole-Genome Shotgun Sequencing;Woman;Women's mortality;Women's prevalence;Work

PROJECT_TITLE: Impact of intestinal helminth infection on HPV co-infection and the cervico-vaginal environment.

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Coffey-Project 3 Narrative The intestine is one of the most renewed epithelium in the body, supplied by active stem cells that can incur mutations leading to colorectal cancer. Two important interacting pathways help to regulate stem cell function and can become misregulated in cancer; these are called the WNT and EGFR signaling pathways. Our goal is to understand the cell non-autonomous function played by secreted vesicles and other secreted factors (EVs and exomeres) and associated secreted RNAs in maintaining the normal balance of stem cells and in driving colorectal cancer progression by regulating EGFR and WNT signaling.

PI_NAMEs: COFFEY, ROBERT J. (contact)

PROJECT_TERMS: Apple;AREG gene;Automobile Driving;Biogenesis;Cell Line;Cells;Cetuximab;Colon;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Data;Drug resistance;EGF gene;Epidermal Growth Factor Receptor;Epithelium;Equilibrium;experimental study;extracellular vesicles;Fluorescence;Genes;Goals;Homeostasis;Human;intestinal crypt;Intestines;KRAS2 gene;LacZ Genes;Large Intestine Carcinoma;LGR5 gene;Link;Luciferases;Malignant Neoplasms;MDCK cell;Mediating;Methodology;Modeling;mouse model;Mus;mutant;Mutation;nanoparticle;Neoplasms;neoplastic;Neoplastic Cell Transformation;Oncogenic;Organoids;overexpression;Pathway interactions;Patients;Pattern;Play;Population;Preparation;Proteins;Publishing;Reagent;Regulation;Reporter;Reporting;Resistance;RNA;Role;Signal Pathway;Signal Transduction;Sorting;stem cell function;stem cell niche;stem cells;Testing;Text;tumor;tumor growth;tumor progression;Tumor-Associated Process;Vesicle;vesicular release;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of WNT-EGFR crosstalk by EVs and exomeres in normal colon and colon cancer


PI_NAMEs: GORBUNOVA, VERA  (contact)

PROJECT_TERMS: Age;Age related pathologies;aged;Aging;aging biomarker;aging process;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Antibodies;Astrocytes;Automobile Driving;Binding Proteins;Brain;Brain region;brain tissue;Breeding;Cardiovascular Diseases;Cell Aging;Cells;cellular pathology;Chemicals;Chiroptera;Chromatin;Chronic;Clinical;clinical development;cognitive performance;cohort;Collaborations;Complementary DNA;Complex;Cytoplasm;Diabetes Mellitus;DNA;DNA biosynthesis;Elements;Engineering;Event;experimental study;extracellular;Family;Fibroblasts;Funding;Genetic;genetic approach;genetic manipulation;Genetic Recombination;Health;healthspan;Human;human disease;Human Genome;Hybrids;improved;Inflammaging;Inflammation;Inflammatory;inhibitor;Interferon Type I;Intervention;Knock-out;Knockout Mice;L1 Elements;Label;life span;Link;longevity gene;LoxP-flanked allele;Malignant Neoplasms;mammalian genome;Mass Spectrum Analysis;Mediating;member;Microglia;Modeling;mouse model;Mus;Mutate;Mutation;Nerve Degeneration;Neurofibrillary Tangles;Neurons;novel;Nucleosides;overexpression;Parasites;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Physical Performance;Physiology;promoter;Proteins;Reporting;Repression;Resources;response;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;RNA;RNA-Directed DNA Polymerase;Role;Senile Plaques;Sequence Analysis;Signal Transduction;Site;small hairpin RNA;Source;Sterility;Stimulator of Interferon Genes;systemic inflammatory response;Testing;Time;Tissues;Transcriptional Activation;transcriptomics;Transgenic Mice;Virus;Work

PROJECT_TITLE: Project 3:  Inhibition of L1 to Alleviate Alzheimer's Disease Pathogenosis in Mouse Models


PHR: Administrative Core Narrative The Administrative Core is important to organize the whole Program, which is focused on understanding how RNA secretion alters the tumor microenvironment and drives colon cancer aggressiveness.

PROJECT_TERMS: Address;Administrator;Advisory Committees;Area;Automobile Driving;Biogenesis;Biology;Cancer Biology;Colon Carcinoma;Communication;Data;Dedications;Educational workshop;Ensure;Environment;experience;extracellular;extracellular vesicles;Feedback;Goals;interdisciplinary approach;interest;Interest Group;Large Intestine Carcinoma;Logistics;meetings;member;Membrane;Mission;Monitor;multidisciplinary;news;Oral;Principal Investigator;programs;Progress Reports;Research;Research Personnel;Resource Sharing;RNA;RNA Interference;scientific organization;Scientist;Structure;synergism;Time;trafficking;tumor microenvironment;Visit;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Despite the increasing availability and effectiveness of antiretroviral therapy, HIV continues to be the greatest pandemic of the last 50 years — 70 million infected, 36 million currently living with HIV and over 1.8 million new infections, including over 180,000 new infant infections annually — so it is imperative to develop an effective population-based approach to reduce transmission. This proposal for the Leadership and Operations Center of the HIV Vaccine Trials Network, the collaboration of scientists at 64 clinical trial sites in 15 countries on 4 continents dedicated to developing a globally effective HIV vaccine, describes the marked advances in candidate vaccines to induce broadly neutralizing antibodies (bnAbs), the advances in bnAbs administered by injection at levels that can prevent infection, and the HVTN’s extensive programs in engaging both local communities and other scientists throughout the world working to stop the spread of HIV. The goal of the HVTN is to develop a vaccine or monoclonal antibody combination that will, either alone or in combination, reduce HIV acquisition in adults and children by more than 60 percent.

PI_NAMEs: BAROUCH, DAN H.;COREY, LAWRENCE  (contact);GRAY, GLENDA E;TOMARAS, GEORGIA DORIS

PROGRAM_OFFICER_NAME: CALDER, THOMAS JAMES

PROJECT_TERMS: Adherence;Adjuvant;Adult;Affect;Africa South of the Sahara;Aftercare;age group;AIDS clinical trial group;AIDS prevention;Animal Model;Antibodies;Antibody titer measurement;Antibody-mediated protection;Antigens;antiretroviral therapy;B-Lymphocytes;Behavior;behavioral and social science;Behavioral Sciences;Binding;Biological;Biological Specimen Banks;Cell Lineage;Child;Childhood;Clinical;clinical development;Clinical Trials;Clinical Trials Network;Collaborations;Combined Vaccines;Communities;community advisory board;community engagement;Complex;computational platform;Consensus;Country;data repository;Dedications;design;diagnostic technologies;Disease;Effectiveness;efficacy evaluation;efficacy testing;efficacy trial;Enrollment;Epidemiology;Epitopes;Event;Feedback;Funding;Genetic;Genotype;Germ Lines;Goals;HIV;HIV Infections;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Human Milk;Immune;Immune response;Immunization;immunogenicity;Immunologics;Individual;Infant;infant infection;Infection;Infection prevention;Infrastructure;Infusion procedures;Injections;insight;Integration Host Factors;International Maternal Pediatric Adolescent AIDS Clinical Trials;Laboratories;Leadership;Licensure;Mediating;Medicine;Mentors;Monoclonal Antibodies;Morbidity - disease rate;mortality;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;novel;novel vaccines;operation;Outcome;pandemic disease;participant enrollment;participant retention;Passive Immunization;people of color;Persons;Phase;Phase I Clinical Trials;phase II trial;Phenotype;Physicians;Placebos;Population;population based;Populations at Risk;pre-clinical;pressure;prevent;Prevention trial;Process;programs;Protocols documentation;Randomized;recruit;Recurrence;Regimen;Research;Research Personnel;Risk;Risk Reduction;Safety;Sampling;Science;Scientist;Severities;Site;Societal Factors;success;Surrogate Markers;System;T-Lymphocyte;Testing;Training;transgender;transmission process;Treatment Failure;Treatment outcome;Tuberculosis;tuberculosis treatment;Tuberculosis Vaccines;Vaccination;vaccine acceptance;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine development;Vaccine Research;vaccine trial;vaccine-induced antibodies;Vaccines;Virus;Work

PROJECT_TITLE: HIV Vaccines Clinical Trials Network Leadership and Operations Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: GAGE, FRED H (contact)

PROJECT_TERMS: 3-Dimensional;Address;Age;age related;Age related pathologies;age-related disease;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Astrocytes;ATAC-seq;attenuation;Biological Models;Brain;brain cell;Cell Line;cell type;Cells;Central Nervous System;Central Nervous System Diseases;chemokine;Chromatin;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;cohort;Collaborations;cytokine;Cytoplasm;Data;design;Disease;Disease Progression;DNA;druggable target;ds-DNA;effective therapy;Elements;Ensure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Evaluation;Exposure to;expression vector;Fibroblasts;fly;Functional disorder;Future;genetic analysis;Heterochromatin;Homeostasis;Human;immune activation;Immune signaling;improved;In Vitro;in vitro Model;Induced Neurons;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Innate Immune Response;Intervention;Life;Life Cycle Stages;Link;Literature;Measurement;Mediating;member;Methods;Minority;Modeling;Molecular;Monitor;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Organoids;overexpression;paracrine;Parkinson Disease;Pathogenesis;Pathologic;Patients;Phenotype;Population;Proteomics;Relaxation;Reporting;Research;response;Retrotransposon;Role;Runaway;Sampling;senescence;senescence associated secretory phenotype;senescent cell;Severity of illness;Signal Transduction;Single-Stranded DNA;Site;Source;Sterility;System;Testing;Therapeutic Intervention;Tissues;transcriptome sequencing;transdifferentiation;vector

PROJECT_TITLE: Project 4: Consequences of Retrotransposable Element Activation in the Central Nervous System


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

PHR: Narrative: The RNA Sequencing and Data Analysis Core will provide expertise and support for all projects in sequencing experiments, multi-omics (eg RNA-Seq and proteomics) data analysis, interpretation, data sharing and integration. We will perform small RNA and total RNA sequencing, provide state-of-the-art multi-level omics data, and develop novel integrative omics methods to provide a comprehensive understanding of exRNA biogenesis and function in colorectal cancer.

PI_NAMEs: SHYR, YU  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;analysis pipeline;Architecture;Area;Barrett Esophagus;Biogenesis;Bioinformatics;Biometry;Biotechnology;ChIP-seq;Collaborations;Colorectal Cancer;Communication;computerized data processing;Data;Data Analyses;data integration;Data Set;data sharing;Dedications;design;DNA sequencing;Ensure;Equipment;experience;experimental study;extracellular;Funding;Genes;Genomics;Goals;Grant;Human Resources;improved;Individual;Joints;Laboratories;laboratory experience;Large Intestine Carcinoma;Leadership;Libraries;Link;lipidomics;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;member;Messenger RNA;Methods;MicroRNAs;Modification;Molecular;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;Preparation;Principal Investigator;programs;Proteins;Proteomics;Protocols documentation;Publications;Qi;Recommendation;Recording of previous events;Research Design;Research Personnel;Research Project Grants;Resources;Ribosomal RNA;RNA;RNA analysis;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Services;skills;Small RNA;System;Technology;Testing;tool;trafficking;transcriptome sequencing;transcriptomics;Transfer RNA;Translational Research;Universities;Work

PROJECT_TITLE: RNA Sequencing and Data Analysis Core


PHR: NARRATIVE – Core 2 The Extracellular Vesicle (EV) Purification and Analysis Core will isolate, quantify, characterize, and assess purity of EVs to be provided to the individual projects so that the needs of the proposed studies are met. The benefit of a central Core for this work is the ability to maintain uniform purification, uniquely skilled technicians, robust characterization of materials, and quality control. Likewise, EV purifications and analyses are particularly well-suited to be performed in a centralized Core as they require specialized equipment and expertise.

PROJECT_TERMS: antibody conjugate;Area;Biochemical;Biogenesis;biomarker development;Cell Culture Techniques;Cell membrane;Cells;Centrifugation;Conditioned Culture Media;cost;Cost Analysis;Culture Media;Dedications;density;Density Gradient Centrifugation;design;Development;Doctor of Philosophy;Endosomes;Equipment;exosome;experimental study;extracellular vesicles;Fluorescence;fluorophore;Future;Goals;Heterogeneity;Individual;innovation;instrumentation;iodixanol;Knowledge;Label;Laboratories;Large Intestine Carcinoma;Left;Light;meetings;Membrane;Methodology;Methods;microvesicles;Molecular;nanoparticle;novel;Participant;particle;Permeability;Population;Population Heterogeneity;Preparation;Procedures;Production;Productivity;program costs;Program Research Project Grants;programs;Property;protein biomarkers;Proteins;Quality Control;Reagent;Reporting;Research;Research Personnel;Resources;RNA;RNA analysis;Sampling;Services;Site;skills;Sorting;Speed;Standardization;Structure;Surface;Technical Expertise;Techniques;technology development;Testing;Training and Education;Vesicle;vesicular release;Work

PROJECT_TITLE: EV Purification and Analysis Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Post-transcriptional regulation can significantly alter gene expression and contribute to Alzheimer’s disease (AD) mechanisms. The proposed research aims to combine bioinformatic and experimental methods to study functional genetic mutations or polymorphisms that cause post-transcriptional changes in AD. This work will provide mechanistic basis for how genetic variations may contribute to AD, such that future interventions can target specific genes therapeutically.

PI_NAMEs: XIAO, XINSHU GRACE (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Bayesian Analysis;Bayesian Modeling;beta-site APP cleaving enzyme 1;Binding;Binding Sites;Bioinformatics;Biological;Biological Assay;Brain;Catalogs;causal variant;Cell Line;Cells;Code;cohort;Collection;Data;Data Set;Dedications;Disease;disease phenotype;disorder risk;DNA;DNA Sequence Alteration;Elements;Environment;Epigenetic Process;Event;experimental study;feature selection;Foundations;Future;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic analysis;Genetic Polymorphism;Genetic Transcription;genetic variant;Genetic Variation;genome-wide analysis;Genotype;Goals;high throughput analysis;Human;human disease;improved;Individual;Intervention;Introns;Measures;Mediating;Messenger RNA;Methodology;Methods;MicroRNAs;Modeling;Molecular Biology;mRNA Expression;novel;Nucleic Acid Regulatory Sequences;Open Reading Frames;Pathogenesis;Pathologic;Pathway interactions;Population;Post-Transcriptional Regulation;posttranscriptional;programs;promoter;Proteins;Regulation;Regulatory Element;Reporter;Reporting;Research;Risk;risk variant;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;Sampling;Susceptibility Gene;System;Testing;Therapeutic;Time;Tissues;tool;Trans-Activators;Transcription Process;Transcriptional Regulation;transcriptome sequencing;Translations;Untranslated RNA;Variant;variant detection;Work

PROJECT_TITLE: Systematic analysis of functional 3’ UTR genetic variants and their relevance to Alzheimer’s Disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Overall Program Narrative Based on the remarkable success of this Program during the prior funding period, this is a proposal to sustain the University of Rochester Resource-based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR), which will continue to provide critical research infrastructure, shared facilities, services and resources to all investigators conducting research on musculoskeletal biology and medicine at the University of Rochester and their collaborators, with the broad overall goal of accelerating, enriching and enhancing the effectiveness of ongoing basic, translational and clinical research and training the next generation of musculoskeletal investigators.

PI_NAMEs: SCHWARZ, EDWARD M. (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Academic Medical Centers;academic program;Acceleration;Address;Animal Model;Award;base;Basic Science;big-data science;Biochemistry;Biocompatible Materials;Biology;Biomechanics;Biometry;bone;Budgets;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;collaborative environment;Communication;Communities;computer program;cost effective;Country;Department chair;Direct Costs;Disparity;Effectiveness;Elements;Endowment;Ensure;Environment;Exercise;Faculty;Female;Fostering;Funding;Goals;Grant;high standard;Histology;human subject;Human Subject Research;improved;Infrastructure;Institution;International;Investments;Laboratories;Leadership;Letters;male;Medicine;meetings;member;Mentors;Mission;molecular imaging;multimodality;Muscle;Musculoskeletal;next generation;novel;Orthopedics;Outcomes Research;outreach;Paper;Physicians;population health;professor;programs;Publications;Recommendation;Reproducibility;Research;Research Assistant;research facility;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;response;Role;Running;Scientist;Series;Services;Structure;success;surgery outcome;symposium;Talents;tenure track;Tissue imaging;tool;Training;translational model;Translational Research;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Despite the current enormous interest in understanding biophysical principles and properties of RNP granules through liquid-liquid phase separation (LLPS) or condensation, we still lack the full understanding of their function in cells. This study identifies a novel stress response pathway that links stress induced cytosolic RNA aggregation into stress granules to transcription regulation. The proposed research will increase our understanding of stress granule function, their role in coupling cytosolic and nuclear stress responses, and illuminate general principles for other RNP condensates and disease associated RNP aggregates.

PI_NAMEs: RIPIN, NINA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affect;Amyotrophic Lateral Sclerosis;analog;Binding;Biochemical;Biological;biological adaptation to stress;biophysical properties;Biophysics;Cell Nucleus;Cell Physiology;Cells;Cellular Membrane;Chromatin;combat;Complex;Computer Analysis;Coupled;Coupling;Cytoplasmic Granules;Cytosol;Data;Data Analyses;Disease;Frontotemporal Dementia;G3BP1 gene;Gene Activation;Gene Chips;Gene Expression;Genes;Genetic Transcription;genome-wide;Genomics;Goals;Homeostasis;human disease;Immunoprecipitation;interest;Ions;Lead;Link;Liquid substance;Mass Spectrum Analysis;Mediating;Mediator;Medical;Mentorship;Metals;misfolded protein;mRNA Stability;mRNA Translation;Muscular Dystrophies;Mutation;novel;Nuclear;Organelles;paralogous gene;Pathway interactions;Phase;Physical condensation;posttranscriptional;Process;Promoter Regions;Property;protein aggregation;Proteins;Regulatory Pathway;Research;response;Ribonucleoproteins;RNA;RNA-Binding Proteins;Robin bird;Role;Scaffolding Protein;Signal Transduction;Stress;stress granule;stressor;Techniques;Training;transcription factor;Transcription Regulation Pathway;Transcriptional Regulation;transcriptome sequencing;Translational Repression;Untranslated RNA

PROJECT_TITLE: The role of Stress Granules and G3BP1 in coupling cytosolic and nuclear stress responses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to understand immune imprinting and memory recall on a molecular level. We wish to determine the structural correlates of antibody protection against evolving viral pathogens by mapping of antibody epitopes onto protein structure. Insights gained will not only shed light on the basic B cell biology but may also inform better vaccination strategies.

PI_NAMEs: BAJIC, GORAN  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Affect;Animal Model;Anti-viral Response;Antibodies;Antibody Affinity;Antibody Repertoire;Antibody Response;Antibody Specificity;Antibody-mediated protection;Antigenic Variation;Antigens;arms race;B cell repertoire;B-Lymphocytes;Binding;Biochemical;Biological Assay;Blood Cells;breakthrough infection;Cell Compartmentation;Cells;Cellular biology;Complex;Containment;Coronavirus;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;Cryoelectron Microscopy;Data;design;Dimensions;draining lymph node;Epitopes;Evolution;Exposure to;Frequencies;Genes;Genetic;Goals;Health;Human;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunization;Immunodominant Epitopes;Immunoglobulin Somatic Hypermutation;Immunologic Memory;Immunology;imprint;Individual;Infection;Influenza;influenzavirus;insight;longitudinal analysis;Maps;Membrane Glycoproteins;Memory B-Lymphocyte;memory recall;Modeling;Molecular;Monoclonal Antibodies;Mutate;Mutation;N-terminal;novel;novel vaccines;pathogen;pathogenic virus;Plasmablast;Population;Primary Infection;protein structure;Proteins;Reaction;receptor binding;recurrent infection;Research;response;RNA vaccine;Sampling;SARS-CoV-2 spike protein;SARS-CoV-2 variant;seasonal coronavirus;Seasons;Specificity;structural biology;Structure;Structure of germinal center of lymph node;Time;Tissues;translation to humans;Vaccination;vaccination strategy;Vaccine Antigen;Vaccine Design;vaccine formulation;vaccine trial;vaccine-induced antibodies;Vaccinee;Vaccines;vaccinology;Variant;variants of concern;Viral;Virus;Visualization

PROJECT_TITLE: Structural interrogation of vaccine- and infection-induced B cell responses

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This award will support Dr. Aline Thomas to obtain an independent research career developing clinically- translatable, noninvasive imaging biomarkers to evaluate cell behavior in disease and in response to therapy. Dr. Thomas aims to enhance the utility of MRI (1) by developing imaging agents that can detect immune evasion and (2) by developing post-processing methods to monitor and quantify these agents when imaged simultaneously.

PI_NAMEs: THOMAS, ALINE  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Applications Grants;Award;Binding;Biological Markers;Biological Process;biomaterial compatibility;Biomedical Engineering;Cancer Patient;cancer therapy;Cancerous;career;cell behavior;Cell Line;Cell Physiology;Cells;Chemicals;clinical translation;Collaborations;Color;Compensation;cytokine;Data;design;detection method;Disease;DU145;Evolution;Failure;Flow Cytometry;Functional disorder;Genetic;Glutamine;Goals;Grant;Histology;Human;Image;imaging agent;imaging biomarker;imaging detection;Imaging technology;Immune;immune cell infiltrate;Immune Evasion;Immunity;Immunologic Monitoring;Immunosuppression;Immunotherapy;In Vitro;in vivo;Infiltration;insight;Label;Learning;Leucocytic infiltrate;Leukocytes;LNCaP;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;molecular imaging;Monitor;mouse model;Natural regeneration;new technology;non-invasive imaging;Optical Methods;patient response;PC3 cell line;Peptides;Play;Preparation;programmed cell death ligand 1;programs;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Protons;quantitative imaging;radio frequency;Regimen;Reporter Genes;Research;Research Personnel;Safety;Salicylic Acids;Scheme;Selection for Treatments;Signal Transduction;spatiotemporal;success;Surface;symposium;Testing;Therapeutic;therapeutic gene;Training;Translating;translational potential;treatment response;tumor;Tumor Escape;Tumor Immunity;tumor progression;uptake;Validation;Visualization;Work

PROJECT_TITLE: Imaging Prostate Cancer Immune Evasion using Chemical Exchange Saturation Transfer MRI


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project narrative This project aims to develop basic science, methods, and technologies that substantially improve our understanding of biological processes focusing on drug discovery from natural sources and that enable synthetic biological development of pharmaceuticals. Ultimately, the resulting technologies will find use in biomedical applications including cancer chemotherapy.

PI_NAMEs: SCESA, PAUL DAVID (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Acetates;Acids;Acyl Coenzyme A;Address;Agreement;Alcohols;amidase;Anabolism;analog;Animals;Aquaculture;Area;Bacteria;Basic Science;beta Tubulin;Binding;Binding Proteins;Biochemical;Biochemical Pathway;Biochemistry;Biological Assay;biological development;Biological Process;Cancer cell line;career development;Cells;chemical group;chemical synthesis;Chemicals;Chemotherapy-Oncologic Procedure;Chromosomes;Creativeness;Cyclization;Cytochrome P450;Dehydration;Diterpenes;drug discovery;eleutherobin;Engineering;Enzymes;Escherichia coli;Evaluation;farnesyltranstransferase;Fermentation;functional group;Gene Cluster;Genes;Goals;Growth;Harvest;improved;Incubated;innovation;Investigation;Laboratories;marine natural product;Membrane;Mentors;Metabolism;Methods;mevalonate;Microsomes;Microtubule stabilizing agent;mutant;NADPH-Ferrihemoprotein Reductase;Natural Products;Natural Source;novel;Operon;Organic Synthesis;Oxidases;oxidation;Paclitaxel;Pathway interactions;Pharmacologic Substance;Plasmids;Production;protein aggregation;Proteins;reconstitution;Reporting;Research;Resistance;Route;Saccharomyces cerevisiae;Scientist;Series;Structure;success;synthetic biology;System;Technology;Terpenes;Testing;Thermodynamics;tool;Training;Transferase;Work;Yeasts

PROJECT_TITLE: Elucidating and engineering eleutherobin biosynthesis


NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE CD8 T cells are protective in draining lymph nodes and pathogenic in cutaneous leishmaniasis lesions. This proposal aims to understand how the lesion microenvironment determines the pathogenic phenotype of CD8 T cells, in order to develop new host-directed therapies for this chronic and debilitating disease.

PI_NAMEs: NOVAIS, FERNANDA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Antibiotic Therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Death Induction;Cell Physiology;Cell Separation;Cells;Chronic;Clinical;comparative;Cutaneous;Cutaneous Leishmaniasis;cytokine;Cytolysis;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Dermal;Development;Disease;disease model;draining lymph node;Drug usage;dysbiosis;Exhibits;Foundations;Genes;genetic signature;Germ-Free;Granzyme;healing;Human;Hypoxia;Immune response;immunopathology;Infection;Inflammation;Inflammatory;insight;Interferon Type II;Interleukin-1 beta;Interleukin-15;JAK1 gene;Knowledge;Leishmania;Leishmaniasis;Lesion;lymph nodes;Mediating;microbial;microbiota;Molecular;mouse model;Mus;neutrophil;Neutrophil Infiltration;Oxygen Consumption;Parasite Control;Parasites;Pathogenicity;Pathology;Pathway interactions;Patients;perforin;Phenotype;Play;prevent;prognostic indicator;programs;Proteins;Publishing;recruit;response;Risk;Role;Severity of illness;Signal Transduction;single-cell RNA sequencing;Skin;skin microbiota;T-Cell Development;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic development;therapy design;Tissues;Topical Antibiotic;transcription factor;Vaccines

PROJECT_TITLE: Distinct functions for CD8 T cells in cutaneous leishmaniasis

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The incidence of obesity and metabolic dysfunction continues to rise, particularly among women; a detrimental consequence is increased breast cancer risk and worse patient outcome. This proposal will 1) advance our understand of obesity’s impact breast cancer; 2) examine if a novel weight loss strategy, intermittent energy restriction, can eliminate obesity-associated tumor progression; and 3) investigate if this intervention will be valuable for helping breast cancer patients improve outcomes.

PI_NAMEs: CATENACCI, VICTORIA A;KABOS, PETER ;MACLEAN, PAUL S. (contact)

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: Acceleration;Adherence;Adipocytes;Adult;Adverse effects;Affect;Age;Anti-estrogen Therapy;Attention;Attenuated;Behavior Therapy;Behavioral;Biological;Biological Markers;Body Weight decreased;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;Breast Cancer Risk Factor;Breast Cancer survivor;Caloric Restriction;Cancer Control;cancer risk;cancer subtypes;Cells;Cessation of life;Characteristics;circulating biomarkers;Clinical;Clinical Research;clinically relevant;common treatment;Data;Development;dietary;Dietary Intervention;Disease;Disease susceptibility;efficacy trial;epidemiology study;Estrogen receptor positive;Estrogens;Extracellular Matrix;Face;Fibroblasts;Foundations;Future;Growth;Health;Health Benefit;hormone therapy;Human;Immune;improved;improved outcome;Incidence;Individual;Inflammatory;innovation;interdisciplinary collaboration;Intermittent fasting;Intervention;intervention delivery;intervention refinement;Intervention Studies;Intervention Trial;Lead;Life Style;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Mediator;Medical Oncology;Menopausal Status;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modality;Modeling;Neoplasm Metastasis;Newly Diagnosed;novel;novel therapeutic intervention;nutrition;Obesity;obesity treatment;Outcome;Overweight;patient derived xenograft model;patient population;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Patients;Persons;Phase;Play;Postmenopause;preclinical study;Predisposition;Premenopause;Prognosis;Protein Secretion;Quality of life;Randomized;Research Personnel;Resistance development;Risk;Role;Science;Specific qualifier value;Stromal Cells;Structure;therapy outcome;Thinness;Time;Time-restricted feeding;Translating;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Subtype;Weight;weight loss intervention;Woman;women's outcomes;Work

PROJECT_TITLE: Novel dietary interventions for reducing obesity-associated breast cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Despite the high in incidence of deleterious symptoms associated with menopause in women, the only effective treatment to block these symptoms remains estrogen-based therapies which carry significantly elevated risks of breast/uterus cancer in patients on these therapies. There is a critical need to have a safer alternative to estrogen therapy to alleviate the menopausal symptoms, hot flushes in particular, without the peripheral side-effects. This advanced translational project test if the novel prodrug DHED, which is biologically inert in the periphery but converted to estrogen selectively and only in the brain, can prevent hot flushes while having no peripheral effects on breast/uterus.

PI_NAMEs: MERCHENTHALER, ISTVAN JOZSEF (contact);PROKAI, LASZLO ;PUCHE, ADAM C

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Affect;Age Years;aged;Aging;Alzheimer's Disease;Andropause;Animal Model;Animals;Anterior Pituitary Gland;Anxiety;associated symptom;Behavior;Binding;Blood flow;Body Temperature;Brain;Breast;cancer risk;Cardiac Output;Cardiovascular Diseases;Chest;Chills;Clinical Trials;cognitive function;cohort;Compensation;Data;Development;Drops;drug discovery;early onset;effective therapy;Effectiveness;Elderly man;Elderly woman;Estrogen decline;Estrogen Therapy;Estrogens;Event;Exhibits;experience;Face;Female;Flushing;Frequencies;Functional disorder;Genitourinary system;Gonadal Steroid Hormones;Heart;Hormonal;hormone therapy;Hormones;Hot flushes;Human;Hyperplasia;Hypothalamic structure;Image;improved;Incidence;Intervention;Life;Link;Longitudinal cohort study;Macaca mulatta;Medial;Medical;men;Menopausal Symptom;Menopause;Mental Depression;Modeling;Monitor;Monkeys;Moods;Neck;Neurokinin B;Nicotinic Acids;nonhuman primate;normal aging;novel;Oral;Organ;Osteoporosis;Ovarian aging;Ovariectomy;Palpitations;Participant;Patients;Pattern;Penetrance;Peripheral;pharmacologic;Phenotype;Physiologic Thermoregulation;Postmenopause;Preoptic Areas;prevent;Primates;Process;Prodrugs;Production;Progestins;Property;Quality of life;receptor;Reporting;Research;Resources;response;restraint;Rhesus;Risk;Rodent;Shivering;side effect;Skin Temperature;Sleep;Sleep Disorders;success;Sweating;Symptoms;Tachykinin;Temperature;Testing;Training;translational model;translational therapeutics;Uterine Cancer;Uterus;Woman;Women's Health;Women's prevalence;women's treatment

PROJECT_TITLE: Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The retinal pigment epithelium (RPE) is critical to maintaining our vision, and degeneration of the RPE can lead to irreversible vision loss. This research will examine the basic biology of the RPE and how it supports the health of the retina, allowing our eyes to turn light into a signal that we can perceive as sight. Knowledge of how these processes work is expected to inform the development of therapeutics to combat age-related and genetic blinding diseases.

PI_NAMEs: DU, SAMUEL WANG (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 11 cis Retinal;age related;Age related macular degeneration;aged;base;Binding;Biological Assay;Biology;Blindness;Cell Physiology;cell type;Cells;Cessation of life;chromophore;circadian;circadian pacemaker;circadian regulation;combat;Compensation;Complement;Complex;Cytomegalovirus;Cytoskeleton;Development;Diagnostic;differential expression;Disease;disease model;Down-Regulation;Electrophysiology (science);Endosomes;Epithelium;Exhibits;Exposure to;Extracellular Matrix;Eye;ezrin;Functional disorder;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Recombination;Genetic Transcription;Health;Histologic;Homeostasis;Hour;Human;Human body;human disease;human induced pluripotent stem cells;Image;Impairment;In Vitro;induced pluripotent stem cell;intraperitoneal;Intraperitoneal Injections;Joints;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Lead;Leber's amaurosis;Light;Link;lipid metabolism;Luciferases;Lysosomes;Maintenance;Mediating;Medical;Melanoma;Messenger RNA;MicroRNAs;monolayer;Mus;Nucleotides;Nutrient;Ocular Physiology;Organelles;overexpression;Pathogenesis;Pathway interactions;Pattern;Periodicity;Phagocytes;Phagocytosis;Phenotype;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiology;Play;pleiotropism;postmitotic;posttranscriptional;Process;Property;Proteins;Quantitative Reverse Transcriptase PCR;Regulation;Research;Retina;Retinal Degeneration;Retinal Photoreceptors;RNA Polymerase II;RNA-Induced Silencing Complex;Rodent Diseases;Role;RPE65 protein;Signal Transduction;single-cell RNA sequencing;social;Structure of retinal pigment epithelium;System;Tamoxifen;Testing;Therapeutic;therapeutic development;Tissue-Specific Gene Expression;Tissues;trafficking;Untranslated Regions;Untranslated RNA;Up-Regulation;Vertebrate Photoreceptors;Vision;Visual Acuity;Visual disability;Work

PROJECT_TITLE: microRNA-204 and microRNA-211 regulation of RPE phagocytosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Neurodegenerative diseases, especially Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), are devastating cognitive or motor-disabling conditions, for which there are no therapies currently. We propose to test an innovative genetic tool that helps clear protein aggregates that cause neuronal toxicity from neurons, and investigate its therapeutic effects in vitro and in vivo in AD and PD mouse models. This project may develop a novel potential gene-therapy tool for AD and PD.

PI_NAMEs: YAKOUB, ABRAAM M. (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapy;Amyloid beta-Protein;Animal Model;Animals;Arrhythmia;Autophagocytosis;Autophagosome;Basic Science;Brain;Brain region;Cause of Death;Cell Aggregation;Cells;Chemicals;Chimeric Proteins;Clinical Trials;Cognitive;Cognitive deficits;Dangerousness;Degradation Pathway;delivery vehicle;Dementia;Deposition;design;Development;Disabling condition;Disease;disease model;drug candidate;Drug usage;Dyskinetic syndrome;effective therapy;Engineering;enhanced green fluorescent protein;Excision;Exhibits;Foundations;Future;gene therapy;Genes;Genetic;Glutamates;healthcare burden;Hippocampus;Human;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Injections;innovation;Knock-in;Learning;Licensing;Memory impairment;Motor;motor deficit;mouse model;Mus;mutant;Mutation;Names;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuronal survival;Neurons;neurotoxicity;novel;Organoids;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;Pharmacotherapy;phosphoneuroprotein 14;Poly A;Population;Precision therapeutics;Preclinical Testing;presenilin-1;prevent;Process;promoter;protein aggregation;Proteins;Psychoses;receptor;recruit;reduce symptoms;research clinical testing;side effect;Specificity;Substantia nigra structure;Synapses;Synthetic Genes;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy development;tool;Toxic effect;Vesicle;Viral Vector

PROJECT_TITLE: Autophagon: an Autophagy-Functionalizing Gene Therapy Tool for Neurodegenerative Diseases

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD-R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Stargardt disease is the most common inherited macular degeneration in children that leads to progressive vision loss and eventually to legal blindness by age 50. The macular degeneration seen in Stargardt disease is caused by impaired clearance of toxic molecules that are released by light-sensitive opsin proteins found in photoreceptors when they capture light. In this proposal, I will investigate whether irreversibly blocking the ability of opsins to release these toxic species is a viable strategy to providing long-lasting protection to the retina from light-induced damage, and delay the onset and progression of macular degeneration in STGD1.

PI_NAMEs: HONG, JOHN DONG-HOON (contact)

PROJECT_TERMS: 11 cis Retinal;absorption;adduct;Adolescent;Affect;Age;Age related macular degeneration;All-Trans-Retinol;alpha Subunit Transducin;American;analog;Attenuated;autosome;Back;Binding;Biological Assay;Blindness;Bruch's basal membrane structure;Child;chromophore;Complex;Contact Lenses;crosslink;Dangerousness;Darkness;Deposition;Development;dimer;Dimerization;Disabling;Disease Progression;Dose;Drusen;Electroretinography;Exposure to;Eye;Formates;Future;Genes;Glass;High Pressure Liquid Chromatography;Histology;Impairment;in vivo;Individual;Inherited;inhibitor;Intervention;Knockout Mice;Lasers;Legal Blindness;legally blind;Light;light intensity;Lipids;Lipofuscin;macula;Macular degeneration;Measures;Mediating;Membrane;Membrane Transport Proteins;Mind;Modification;Molecular;Molecular Conformation;Morphology;mouse model;Mus;Mutation;neuroprotection;Nuclear;Ophthalmoscopy;Opsin;Optical Coherence Tomography;Oxidoreductase;Patients;Phenotype;Photoreceptors;Phototransduction;Physical condensation;Pre-Clinical Model;prevent;Production;Property;Proteins;Quality of life;Reaction;Retina;retinal damage;Retinal Photoreceptors;Retinal Pigments;Retinitis Pigmentosa;Retinoids;Rhodopsin;Rod Outer Segments;Scanning;Site;Stargardt's disease;Structure of retinal pigment epithelium;success;Testing;Therapeutic;Thick;translocase;Visible Radiation;Vision;visual cycle;Work

PROJECT_TITLE: Formation of Retinyl-Opsins by Retinyl Formate as Molecular Shades Against Light-Induced Retinal Damage


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The correct topological organization of the B-lymphocyte genome during development and antibody gene diversification events prevents aberrant chromosomal translocations and promote antibody diversification mechanisms. Recent advances in transcriptomics and genomics have identified the role of long noncoding RNA expressing enhancer sequences in the organization of B cell genomes. In this application, we evaluate the role of three long noncoding RNA expressing loci in maintaining the correct architecture and local topology of B cell genomes and for promoting antibody diversification.

PI_NAMEs: BASU, UTTIYA  (contact)

PROJECT_TERMS: 3-Dimensional;Antibodies;Architecture;B-Cell Development;B-Lymphocytes;Binding Sites;Biochemical;Biological Assay;Biological Models;Biology;Cell Line;Chromatin Conformation Capture and Sequencing;chromatin immunoprecipitation;Chromosomal translocation;Chromosomes;cohesin;Complex;Control Locus;CRISPR/Cas technology;CSPG6 gene;Data;Detection;Development;Disease;DNA;DNA Maintenance;DNA Sequence Alteration;dysbiosis;Elements;Enhancers;Event;exosome;Experimental Genetics;experimental study;Genes;Genetic;Genetic Enhancer Element;Genetic Polymorphism;Genetic Recombination;Genetic Transcription;Genome;genome integrity;genome-wide;genomic locus;Genomics;Germ Lines;Grant;High-Throughput Nucleotide Sequencing;Homeostasis;Human;humoral immunity deficiency;Hybrids;IGH@ gene cluster;Immune system;Immunity;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;Immunologics;Impairment;Libraries;Lymphoma;Lymphomagenesis;mammalian genome;Mediating;microbiome;Modeling;Molecular;Molecular Mechanisms of Action;mouse genome;mouse model;Mutation;Nomenclature;novel;Patients;Peyer's Patches;Physiological;Physiology;Post-Transcriptional RNA Processing;prevent;Proteins;Publishing;recruit;Regulation;Regulatory Element;repaired;Research Design;RNA;RNA analysis;RNA-Protein Interaction;Role;Scanning;selective deficiency of Immunoglobulin a;Site;Structure;System;trafficking;Transcript;transcriptomics;Untranslated RNA

PROJECT_TITLE: Long noncoding RNA expressing genomic elements that control antibody diversification and chromosomal integrity in B cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-E(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: MEMPHIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: In this project, we will quantify the relationship between genetic variants, age, diet, sex, mitochondrial DNA copy number, longevity and Alzheimer’s disease using a diverse cohort of BXD and transgenic AD-BXD mouse lines, which segregate for over 6 million genetic variants. This approach allows a chain of causality between genetic variants, environmental effects, cellular processes, and whole-organism outcomes, such as cognitive decline in aging. The use of a genetically and environmentally reproducible population will allow us to integrate all of our data with a previously collected phenome of over 7500 traits and over 110 omics datasets, including longevity, memory, learning, motor, and neuroanatomical phenotypes, as well as translate across species using human genome-wide (GWAS) and phenome-wide (PheWAS) association study data.

PI_NAMEs: ASHBROOK, DAVID GEORGE (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Age;age effect;Age Months;age related;age related changes;age-related disease;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease risk;Behavioral;biobank;Bioinformatics;Biological Assay;Biological Markers;Biological Models;Biology;Blood;Candidate Disease Gene;Cell Physiology;cell type;clinical application;Cognition;Cognitive;Cognitive aging;cognitive performance;cohort;Collection;Complex;Data;data integration;Data Set;Databases;Diet;Disease;DNA;DNA copy number;empowerment;endophenotype;Environment;Etiology;familial Alzheimer disease;Family;Fatty acid glycerol esters;functional decline;Future;gene environment interaction;gene network;Generations;Genes;Genetic;genetic analysis;Genetic Engineering;genetic resource;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Health;healthy aging;High Fat Diet;Hippocampus;Human;Human Genome;Impaired cognition;improved;Inbreeding;Individual;Internet;Intervention;Kidney;Learning;life span;Link;Liver;Liver Mitochondria;Longevity;Measures;Mediating;Memory;Metabolic;metabolome;Methamphetamine;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Motor;mouse model;Mouse Strains;Mus;Muscle;Neuroanatomy;novel;novel therapeutic intervention;Outcome;Outcome Measure;Outcome Study;Pathogenicity;Performance;Peripheral;phenome;Phenotype;Population;precision medicine;Process;Proteome;Proxy;QTL Genes;Quantitative Trait Loci;Reactive Oxygen Species;Recombinants;Reproducibility;Research Proposals;Sampling;segregation;Services;Severity of illness;sex;Sex Differences;Skin;success;System;Testing;Tissues;trait;transcriptome sequencing;Transgenes;Transgenic Organisms;Translating;Variant;web site;Whole Organism;Work

PROJECT_TITLE: The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: This award will provide protected time for Dr. Anna Hemnes to devote specifically to developing mentoring skills in patient-oriented research. Her objective is to recruit and mentor students, residents, fellows and junior faculty for successful clinical research careers in pulmonary vascular disease and to support the career advancement of her current trainees who are fellows and junior faculty members. The proposal here will build on her funded work to test the hypothesis that Omic signatures in PAH can identify features of resilience to PAH progression and metabolic intervention susceptibility.

PI_NAMEs: HEMNES, ANNA R (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Award;Basic Science;Bioinformatics;Blood Vessels;career;career development;Career Mobility;Cessation of life;Classification;Clinic;Clinical;clinical phenotype;Clinical Research;Clinical Trials;cohort;Data;Development;Diagnosis;Disease;Disease Marker;Educational workshop;effective therapy;experience;Faculty;Funding;Goals;Grant;Guidelines;Human;improved;Institution;Insulin Resistance;International;Intervention;large datasets;Lipids;Lung;Lung Diseases;Measures;member;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metformin;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Molecular;molecular phenotype;mortality;National Heart, Lung, and Blood Institute;next generation;novel therapeutics;Outcome;Pathogenesis;patient oriented;patient oriented research;Patients;Phenotype;Postdoctoral Fellow;precision medicine;Predisposition;Productivity;Program Research Project Grants;programs;Prospective cohort;Publications;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Training;resilience;Resources;response;Right Ventricular Dysfunction;right ventricular failure;Scientist;Severity of illness;skills;student mentoring;Techniques;Testing;Time;Training;training opportunity;treatment response;treatment strategy;United States;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Mentorship in Pulmonary Vascular Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: RIVERSIDE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE The molecular mechanisms underlying the establishment of cellular morphologies are largely unclear. This project will investigate the morphology program coordinated by a conserved, neuronally expressed RNA- binding protein, Unkempt. Results of this study will provide important new insight into how shape of neurons and other cell types is controlled in multicellular organisms.

PI_NAMEs: MURN, JERNEJ  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Binding;Binding Sites;Biochemical;Biological Assay;Bipolar Neuron;Cell Physiology;Cell Shape;cell type;Cells;Cellular Morphology;Code;comparative;Coupled;Cues;design;Development;Disease;Dissociation;Endowment;Event;experimental study;Foundations;FRAP1 gene;Gene Expression;Gene Structure;Goals;Homeostasis;human disease;in vivo;Individual;Induced Neurons;insight;Instruction;Length;Life;Link;Locales;Mammalian Cell;Mediating;Messenger RNA;Microscopy;Modality;Molecular;Morphogenesis;Morphology;mRNA Translation;Mutagenesis;Nature;Nervous System Disorder;Neuroglia;Neurons;Organism;Phosphorylation;Phosphotransferases;Play;polarized cell;Poly(A) Tail;Post-Transcriptional Regulation;Post-Translational Protein Processing;Process;programs;protein complex;protein protein interaction;Proteins;Proteomics;recruit;Reporter;ribosome profiling;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Role;Series;Shapes;Site;Somatic Cell;spatiotemporal;Structure;Supporting Cell;Transcript;Translations

PROJECT_TITLE: Investigating the molecular mechanisms of early neuronal morphogenesis

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: PROJECT NARRATIVE Optic neuritis (ON), or demyelinating inflammation of the optic nerve, is strongly associated with Multiple Sclerosis (MS), and 50% of all the MS patients (2.5 million globally) are estimated to develop one or more episodes of ON during the course of their disease. For patients with long-term vision loss from ON who have no effective treatment available, remyelination-based treatment has the potential to help, but the remyelination process in human is not fully understood. Here we propose to use human stem cell derived oligodendrocytes (OLs) and retinal ganglion cells (RGCs) to investigate the mechanism involved in RGC myelination by OLs that can be exploited for promoting remyelination of the demyelinated optic nerve.

PI_NAMEs: CHAMLING, XITIZ  (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Acute;Advisory Committees;Apoptosis;Astrocytes;Axon;axon injury;Biological Assay;Biology;Biometry;Blindness;Candidate Disease Gene;career development;Cell Line;Cells;Chronic;Coculture Techniques;Collaborations;Complement;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Demyelinating Diseases;Demyelinations;DICER1 gene;differentiation protocol;Disease;effective therapy;Environment;Enzymes;Epidermal Growth Factor Receptor;gain of function;Genes;genome editing;Goals;Green Fluorescent Proteins;high throughput screening;Human;human pluripotent stem cell;human stem cell-derived;Image;In Vitro;Incidence;Inflammation;Inflammatory;innovation;insight;Institution;Laboratory Research;Lead;Learning;loss of function;MAP2K1 gene;MAPK3 gene;MEKs;Mentors;MicroRNAs;miRNA expression profiling;Molecular;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin Basic Proteins;myelination;nanoluciferase;Neural Conduction;neuron loss;Neurons;neuroprotection;novel;oligodendrocyte lineage;oligodendrocyte myelination;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;optic nerve disorder;Optic Neuritis;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;Population;precursor cell;Process;programs;Proteins;Proteolipids;Publishing;remyelination;Reporter;Reporting;Research;Research Personnel;Retinal Ganglion Cells;Role;Scientist;screening;Signal Pathway;single-cell RNA sequencing;small molecule;SOX5 gene;SOX6 gene;Specific qualifier value;stem cell differentiation;stem cells;symposium;System;Techniques;tool;Training;transcription factor;Validation;Vision;Visual Acuity;Work

PROJECT_TITLE: Developing Remyelination Strategies for Demyelinating Optic Neuropathies Using Human Pluripotent Stem Cells

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Most cancer patients experience financial hardship as a direct result of receiving expensive cancer care and lost income. Our study will test the effectiveness of a multicomponent financial counseling program, CostCOM, that will help patients with newly diagnosed cancer at NCI community oncology research program (NCORP) practices across the United State to learn about their personalized treatment out-of-pocket costs using a price estimator tool, understand their insurance benefits, and receive financial navigation (e.g., get enrolled in financial assistance programs). We anticipate that CostCOM compared to enhanced usual care will improve cost-related cancer care nonadherence and quality of life and decrease material financial hardship and financial worry.

PI_NAMEs: SADIGH, GELAREH  (contact)

PROGRAM_OFFICER_NAME: CASTRO, KATHLEEN M

PROJECT_TERMS: Address;Advocate;arm;cancer care;cancer diagnosis;Cancer Patient;cancer therapy;care costs;care delivery;Caring;Client satisfaction;Communication;Community Clinical Oncology Program;comparative cost effectiveness;Complex;Conduct Clinical Trials;cost;cost effectiveness;Counseling;Diagnosis;Disclosure;Dose;Drug Prescriptions;Education;Effectiveness;effectiveness evaluation;effectiveness testing;enhanced care;Enrollment;Ethnic Origin;experience;Financial Hardship;Financial Support;follow up assessment;Foundations;Geography;Goals;Health;health care service utilization;Health system;Hospitals;Hour;improved;Income;innovation;Insurance Benefits;Insurance Coverage;interest;Intervention;Interview;Learning;Link;Malignant Neoplasms;Measures;Medical;multidisciplinary;multiple sclerosis patient;Newly Diagnosed;Nonmetastatic;Office Visits;Outcome;Pamphlets;participant enrollment;patient engagement;Patient Outcomes Assessments;patient population;Patient Self-Report;Patients;Perception;personalized intervention;personalized medicine;Population;Preparation;Price;primary endpoint;primary outcome;process evaluation;Professional counselor;Program Sustainability;programs;Provider;Qualitative Methods;Quality of life;Race;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Resources;Risk;satisfaction;Services;shared decision making;Site;socioeconomics;Solid Neoplasm;Surveys;System;telecoaching;telephone session;Testing;therapy design;Time;tool;treatment as usual;Treatment Cost;Uninsured Medical Expense;United States;United States Centers for Medicare and Medicaid Services;usual care arm;video session

PROJECT_TITLE: Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Immunotherapy;Orphan Drug;Rare Diseases;Stomach Cancer

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Metastatic gastroesophageal adenocarcinoma contributes heavily to global cancer-related death. Our project will contribute fundamental knowledge on the effectiveness of a novel serial immunotherapy combination in patients with this disease and on its biologic impact so as to further optimize this approach. Upon successful completion of this research, these findings are expected ultimately to improve the survival of patients with this disease.

PI_NAMEs: YOON, HARRY H (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Aftercare;anti-PD1 antibodies;anti-tumor immune response;antiangiogenesis therapy;Antineoplastic Agents;arm;bevacizumab;Biological;Biological Assay;Blood specimen;Cancer Etiology;cancer therapy;Cause of Death;CD8-Positive T-Lymphocytes;Cessation of life;chemotherapy;Clinical;clinical efficacy;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;Cytometry;Cytotoxic agent;Cytotoxic Chemotherapy;Data;density;design;Development;Disease;Disease Progression;Distant Metastasis;Drug Efflux;effective therapy;Effectiveness;Environment;experimental arm;Flow Cytometry;FOXP3 gene;Future;gastroesophageal adenocarcinoma;gastroesophageal cancer;Goals;Granzyme;Immune;immune activation;Immune checkpoint inhibitor;Immune response;immunoregulation;Immunotherapy;improved;In complete remission;Infiltration;innovation;insight;KDR gene;Knowledge;Malignant Neoplasms;Medical;Microanatomy;Minority;novel;novel therapeutic intervention;Outcome;Paclitaxel;Parents;Patients;pembrolizumab;Pharmaceutical Preparations;phase II trial;Pilot Projects;preservation;primary endpoint;programmed cell death protein 1;Regimen;Regulatory T-Lymphocyte;Research;Resistance;response;Sampling;Selection for Treatments;T-Lymphocyte;taxane;Testing;Time;Treatment Efficacy;tumor;Tumor Promotion;tumor-immune system interactions

PROJECT_TITLE: Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Double stranded RNAs are exciting regulatory molecules, powerful tools for basic biological sciences, and targets for novel therapeutic approaches. This proposal will explore chemical modifications to optimize the properties of such RNA molecules and study the mechanism of their action. If successful, the project will create improved research tools, provide unique insights into structure and function of RNA and may open doors for development of new drugs for diseases where the traditional pharmaceutics have been less successful.

PI_NAMEs: ROZNERS, ERIKS  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Amides;analog;Binding;Biological;Biological Sciences;Biology;Biotechnology;Charge;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;CRISPR interference;design;Development;Disease;DNA;Double-Stranded RNA;Electrostatics;Future;genetic information;Goals;improved;inorganic phosphate;insight;Ligand Binding;Ligands;Medicine;Membrane;Modification;Molecular Conformation;new therapeutic target;non-Native;novel;novel therapeutic intervention;novel therapeutics;nucleobase;Oligonucleotides;Organelles;Peptide Nucleic Acids;Pharmacy (field);Phase;Productivity;programs;Property;Proteins;Research;RNA;RNA Binding;RNA Interference;RNA-Protein Interaction;Small Interfering RNA;Specificity;Structure;Technology;Therapeutic;tool;Untranslated RNA;uptake;Vertebral column

PROJECT_TITLE: Chemical Approaches to Control the Function of Regulatory RNAs

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cannabinoid Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Substance Misuse

ORG_CITY: PRINCETON

ORG_NAME: RICOVR HEALTHCARE INC.

ORG_STATE: NJ

PHR: Project narrative The overall goal of the proposed research is to create an effective and scalable point-of-need (PoN) diagnostic test device using oral fluid with a simplified workflow to test as a tool to improve recovery/withdrawal follow-up strategies for cannabis use disorder (CUD) patients and drug screening in the workplace.

PI_NAMEs: SEIMETZ, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Address;Adopted;antibody conjugate;Biological;Biological Assay;Biosensor;Buffers;Cannabis;Clinical;Collection;commercialization;Companions;Computer software;Computers;Consumption;cost;Coupled;Data Analyses;Data Collection;Deposition;design;Detection;detection assay;detection method;Development;Devices;Diagnostic;Diagnostic tests;drug of abuse;Drug Screening;Engineering;Fiber Optics;follow-up;Future;Geometry;Goals;Healthcare;high throughput screening;Hospitals;Hydrophobicity;Immunoassay;Impairment;improved;improved outcome;Instruction;Intervention;Kinetics;laboratory development;Law Enforcement;Liquid substance;Literature;manufacture;marijuana legalization;marijuana use;marijuana use disorder;Marketing;Measurement;meter;Methods;Microfluidics;Monitor;monitoring device;nanoGold;Oral;Parents;patient screening;Patient-Focused Outcomes;Peptide Hydrolases;Pharmaceutical Preparations;Phase;plasmonics;Preparation;prevent;Process;Professional counselor;Proteins;prototype;Reader;Reagent;Recovery;Recreation;remote grading;Research;Safety;Saliva;saliva sample;Sampling;Schools;screening;social stigma;Software Tools;Stigmatization;Substance Use Disorder;Surface;Swab;Technology;Testing;Time;tool;Training;trend;Tube;United States Substance Abuse and Mental Health Services Administration;Urine;Variant;Viscosity;Withdrawal;Work;Workplace

PROJECT_TITLE: Advancement of a Point-of-Need (PoN) platform device for accurate and destigmatized detection of recent cannabis use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative: A primary challenge of modern genomics is to understand how DNA sequence encodes regulatory information and how trans-acting factors interpret this information to generate gene expression programs specific to a cell type and context. We propose to utilize both population studies and a comparative perspective, to reveal the genomic mechanisms that control gene expression programs that are dynamic in both space and time.

PI_NAMEs: GILAD, YOAV  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Area;Award;cell type;Cells;Communities;comparative;Complex;Cues;Data;Disease;DNA Methylation;DNA Sequence;Epigenetic Process;Evolution;Gene Duplication;gene environment interaction;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;genetic variant;Genetic Variation;Genomics;histone modification;Human;human disease;human induced pluripotent stem cells;improved;In Vitro;Individual Differences;individual response;induced pluripotent stem cell;insight;Malignant Neoplasms;Maps;Mediating;Methods;Modernization;Molecular;Natural Selections;Nervous System Disorder;Noise;novel strategies;Pan Genus;Phenotype;Pongidae;Population Study;Process;programs;response;Role;Shapes;single cell technology;System;Time;Tissues;trait;Trans-Activators;Untranslated RNA;Variant;Work

PROJECT_TITLE: Characterizing and Understanding Variation in Gene Regulatory Mechanisms Within and Between Species

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MRAF-C (01)]


ADMINISTERING_IC: CE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: UNIVERSITY OF IOWA INJURY PREVENTION RESEARCH CENTER  PROJECT NARRATIVE The University of Iowa (UI) Injury Prevention Research Center (IPRC) aims to prevent, control, and optimize recovery from injuries and violence, especially in rural communities. The UI IPRC works toward this goal through research, training and education, and outreach, focusing on rural populations and multiple types of injury and violence. The UI IPRC will continue its strong tradition of multidisciplinary, collaborative, and integrated activities that engage diverse areas of expertise and multiple local, state, and national partners.

PI_NAMEs: CASTEEL, CARRI  (contact)

PROJECT_TITLE: CE24-001, Grants for Injury Control Research Centers (ICRC) - 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 MLW (4A)]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Narrative  Many of the chemicals that cause cancer are made either more or less active by cytochrome P450 (P450) enzymes in the body. Three enzymes are also involved in the metabolism of drugs, including those used to treat cancer. The enzymes are also involved in the metabolism of steroids and influence hormone action.

PI_NAMEs: GUENGERICH, F PETER (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Binding Proteins;Cancer Etiology;Cellular biology;chemical carcinogen;Chemicals;Cytochrome P450;Cytochromes;Cytochromes b5;Development;Directed Molecular Evolution;Drug Industry;Drug Interactions;drug metabolism;Endocrine System Diseases;Endocrinology;Enzyme Kinetics;Enzymes;experimental study;Hormones;Human;improved;Laboratories;lipophilicity;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Medical;Microsomes;Mitochondria;Molecular;Molecular Biology;Organic Synthesis;Orphan;Oxidants;oxidation;Pharmaceutical Preparations;Physiological;practical application;Protein Engineering;Proteomics;Reaction;Research;Retinoids;Role;Skin;Spectrum Analysis;steroid metabolism;Steroids;success;Techniques;Training;Variant;X-Ray Crystallography

PROJECT_TITLE: Functional Roles of Human Cytochrome P450 Enzymes

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]