ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE African American women experience greater chronic stress as evidenced by higher allostatic load over the life course compared to all men and white women, which may drive higher incidence and earlier onset of hypertension in this group. Although young African-American women are a prime target for primary and secondary prevention, the development of effective prevention-focused interventions is inhibited by limited understanding of underlying mechanisms in this subgroup. This application will fund studies to: 1) capture the unique stress experiences of young, African-American women and their physiological responses in real-time within daily life; and 2) use these data in conjunction with extant literature and community engagement to develop and pilot test a stress reduction intervention targeting blood pressure improvement in this population.

PI_NAMEs: HINES, ANIKA LATRICE (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;African American population;African American Women;Aftercare;Age;allostatic load;arm;Award;Behavior;behavior change;Behavior Therapy;behavioral clinical trial;Behavioral Medicine;behavioral response;biological adaptation to stress;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;career development;Chronic;Chronic Disease;Chronic stress;Clinical;community engagement;Complex;coping mechanism;Coping Skills;Coupled;Data;design;Development;Devices;Diabetes Mellitus;Discrimination;Disparity;early onset;Ecological momentary assessment;Electrocardiogram;Emotions;End stage renal failure;Endocrine;Ensure;Environment;ethnic minority;Ethnic Population;evidence base;Evidence based intervention;experience;Exposure to;feasibility testing;Foundations;Funding;Gender;Goals;Grant;Health;Health behavior;health disparity;health equity;Health Policy;Health Services;Health Services Research;heart rate variability;Hour;Hypertension;implementation evaluation;improved;in vivo;Incidence;Individual;Inflammatory Response;innovation;Intervention;intervention refinement;Intervention Trial;Interview;K-Series Research Career Programs;laboratory experience;Life;Life Cycle Stages;life span;Link;Literature;Lived experience;male;Measures;medical schools;men;Mentors;Methods;mobile application;Monitor;Moods;Morbidity - disease rate;mortality;neural;novel;Obesity;Outcome Assessment;Participant;Pathway interactions;Physiologic Monitoring;Physiological;pilot test;pilot trial;Policies;Population;Preparation;Prevention;Primary Prevention;professor;Protocols documentation;psychologic;Qualitative Methods;Race;racial disparity;racial minority;racial population;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Research Training;response;Risk;Risk Factors;Sample Size;satisfaction;Secondary Prevention;sex;skills;social epidemiology;social stress;Solid;Statistical Data Interpretation;Stress;Stress and Coping;stress management;stress reduction;Stressful Event;stressor;Subgroup;Surveys;Technology;Testing;therapy development;Time;Training;Universities;Virginia;Vulnerable Populations;wearable device;White Women;Work

PROJECT_TITLE: Developing Novel Intervention Approaches to Mitigate Cardiovascular Risk among Young African-American Women

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal will test if delivery room resuscitation of preterm infants < 31 weeks GA with 75th percentile SpO2 targets (Sat75) compared to 50th percentile SpO2 targets (Sat50) will result in better pulmonary transition, less oxidative stress and increased survival without bronchopulmonary dysplasia by 36 weeks’ postmenstrual age. If the research hypothesis is proven, it provides a simple and inexpensive way to reduce death or bronchopulmonary dysplasia in preterm infants worldwide. Further, it has potential to transform the delivery room management of preterm infants worldwide.

PI_NAMEs: KAPADIA, VISHAL S (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 2 year old;Address;Admission activity;adverse outcome;Age;Biological Markers;Birth;Blood specimen;Bradycardia;Bronchopulmonary Dysplasia;Cessation of life;Clinical Trials;Data;Delivery Rooms;design;Enrollment;Equilibrium;Expert Opinion;Funding;Gestational Age;Goals;Guidelines;Hour;Hyperoxia;Hypoxia;improved;improved outcome;Incidence;Infant;Intervention;intraventricular hemorrhage;Isoprostanes;Knowledge;Link;Lung;Measures;Morbidity - disease rate;mortality;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;neonatal care;neonatal outcome;neonatal resuscitation;Neurodevelopmental Impairment;Outcome;Oxidative Stress;Oxygen;Patients;Pilot Projects;positive airway pressure;Premature Infant;primary outcome;programs;Pulmonary Hypertension;Pulmonary Vascular Resistance;Randomized;Randomized, Controlled Trials;Recommendation;Research;respiratory;Respiratory Failure;Resuscitation;secondary outcome;Site;Specific qualifier value;Survival Rate;Testing;Time;Titrations;Umbilical Cord Blood

PROJECT_TITLE: Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Rare Diseases;Tuberous Sclerosis

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Research under this grant is aimed at defining how the major lines of communication function in normal cells and become dysfunctional in cancer cells to promote uncontrolled cell growth, with a focus on one of the most commonly activated pathways in human cancers (the mTOR pathway). Development of novel therapeutic strategies to destroy cancer cells displaying activation of this pathway is a major aim of these studies.

PI_NAMEs: MANNING, BRENDAN D. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: analytical tool;anti-cancer research;Area;Biochemical;Biological;cancer cell;cell growth;Cells;Cellular biology;Communication;Complex;Development;Family;FRAP1 gene;Funding;Genetic;Genetic Models;Goals;Grant;Growth;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Human;in vivo;innovation;Investigation;Link;Malignant Neoplasms;member;Metabolic;Metabolic Pathway;Methodology;Molecular;Monomeric GTP-Binding Proteins;mouse model;mTOR Inhibitor;Normal Cell;novel;novel therapeutic intervention;Nutrient;Oncogenes;Oncogenic;Pathway interactions;PIK3CG gene;Proliferating;protein complex;Publishing;Regulation;Research;Resources;Role;Signal Pathway;Signal Transduction;Therapeutic;therapeutic target;Tuberous Sclerosis;tumor;tumor metabolism;tumor microenvironment;Tumor Suppressor Proteins;uncontrolled cell growth;Work

PROJECT_TITLE: Decoding and Targeting the PI3K-mTOR Signaling Network in Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Neurofibromatosis;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE This project aims to advance the application of small molecule therapeutic strategies to treat people with NF1 - associated malignant peripheral nerve sheath tumors (MPNST). We have discovered that novel small molecule inhibitors of SHP2 are active against models of MPNST and will now investigate mechanisms by which tumors become resistant, and use these data, and our current preliminary data, to test novel combinations, including the combination of SHP2 and CDK4/6 inhibitors. We will investigate the effects of these targeted therapies not only on the tumor cells, but also on the immune cells which comprise the tumor microenvironment, in order to devise therapies that hold promise to produce potent activity in clinical trials in people with MPNST.

PI_NAMEs: PRATILAS, CHRISTINE ANNE (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Affect;Animal Model;Biochemical;Biological;Biological Assay;Biological Markers;CDK4 gene;Cell Culture Techniques;cell type;Cells;checkpoint inhibition;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;Clinical Trials;combinatorial;Combined Modality Therapy;Conditioned Reflex;Data;design;Development;Dimensions;Disease;early phase clinical trial;efficacy evaluation;Elements;Feedback;Flow Cytometry;Future;genetic manipulation;Genetic Transcription;Genomics;GTPase-Activating Proteins;Human;hyperactive Ras;Immune;immune cell infiltrate;Immune response;Immunocompetent;immunodeficiency;Immunohistochemistry;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo evaluation;Infiltration;inhibitor;Investigation;Knowledge;Location;loss of function;Mediator;MEK inhibition;MEKs;Modeling;Molecular Target;Morbidity - disease rate;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;Neurofibrosarcoma;new therapeutic target;NF1 gene;novel;novel drug class;novel therapeutic intervention;novel therapeutics;Oncogenic;Operative Surgical Procedures;Pathologic;Pathway interactions;patient derived xenograft model;patient response;Patient Selection;Patients;Persons;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;Predisposition;Primary Neoplasm;programs;protein function;Proteomics;PTPN11 gene;rare cancer;ras GTPase-Activating Proteins;Ras Inhibitor;rational design;Receptor Protein-Tyrosine Kinases;Reporting;Research;Resistance;resistance mechanism;response;Role;Safety;Sarcoma;Schwann Cells;Signal Pathway;Signal Transduction;small molecule inhibitor;small molecule therapeutics;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapy design;Time;tool;Toxic effect;transcriptomics;Translating;tumor;Tumor Immunity;tumor microenvironment;Tumor Suppressor Genes;tumor-immune system interactions;Tumor-infiltrating immune cells;Up-Regulation;Validation

PROJECT_TITLE: Advancing RAS pathway targeted therapy in NF1-MPNST: effects of SHP2 and CDK4/6 inhibitors on the tumor and the tumor immune microenvironment

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because despite decades of research aimed at racial equity, Black Americans have experienced long-standing racial disparities in the receipt of quality end-of-life care and there have been no interventions that addresses structural racism in end-of-life care. This study seeks to understand and address structural racism as a root cause of racial disparities in end-of-life care using community based participatory research methods from a life course perspective. This proposed research is relevant to the National Institute of Aging's mission to improve the health and well-being of older adults because it seeks to understanding structural racism and designing and testing the feasibility and acceptability of an intervention to address structural racism in end-of-life care in older adults.

PI_NAMEs: DZENG, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Adult;Alabama;American;anti-racism;Area;Asian Americans;Attitude;Award;Black American;Black race;career development;Caring;Clinical;clinical care;Clinical Trials;cohort;Communities;community academic partnership;community advisory board;community based participatory approach;community based participatory research;community-level factor;Crows;design;Development Plans;Discrimination;driving force;Economics;Education;effectiveness/implementation hybrid;Elderly;Empathy;Employment;end of life;end of life care;Ethicists;experience;Face;Failure;Family member;feasibility testing;Future;Geriatrics;Goals;Health;health care disparity;health equity;Health Services Accessibility;Health system;Healthcare;Hospital Administrators;Hospitalists;Hospitals;Housing;human centered design;implementation science;improved;Incentives;Individual;Inequity;innovation;Institution;Institutional Racism;International;Intervention;Intervention Studies;Interview;Knowledge;Leadership;Learning;lens;Life Cycle Stages;Life Experience;Lived experience;maltreatment;member;Mission;multi-component intervention;multidisciplinary;mutual learning;National Institute on Aging;neglect;novel;older adult;Outcome;Pain management;Palliative Care;Pathway interactions;Perception;Personal Satisfaction;Persons;Police;Policies;pragmatic trial;preference;protocol development;Public Health;racial disparity;Racial Equity;racism;Recording of previous events;Research;Research Methodology;Research Personnel;San Francisco;Scholarship;Shapes;Site;skills;Social Environment;Social Justice;sociologist;Structural Racism;Structure;System;Testing;theories;therapy development;tool;Training;Universities;Variant;Woman;Work

PROJECT_TITLE: Understanding and addressing structural racism and its impact on the quality of end-of-life care in older Black adults


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Rural Health;Substance Misuse;Telehealth

ORG_CITY: SPOKANE

ORG_NAME: MANAGED HEALTH CONNECTIONS, LLC

ORG_STATE: WA

PHR: Project Narrative As few as 15% of individuals ever receive treatment for alcohol use disorders. New alcohol biomarkers and mobile technology allow for us to deliver interventions for alcohol use disorders outside clinical settings. The goal of the system will be to provide an end-to-end contingency management platform, which can aggregate and inform the understanding of mechanisms underlying the initiation, maintenance and recovery from problematic drinking in both treatment and naturalistic settings little to no required clinician involvement.

PI_NAMEs: JOHNSON, RON KIMBERLY (contact);MCDONELL, MICHAEL G;MCPHERSON, STERLING M

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;addiction;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol intervention;alcohol monitoring;alcohol use disorder;Alcohols;Android;Appointment;Architecture;barrier to care;Behavior;behavior change;Behavior Therapy;Biological;Biological Markers;Bluetooth;Cellular Phone;Child Care;Clinic;Clinical;clinical application;clinical decision support;Cognition;commercialization;Commuting;Computerized Medical Record;contingency management;Control Groups;cost effective intervention;craving;Data;design;Development;Devices;drinking;Drug Addiction;Ecological momentary assessment;efficacy evaluation;electronic medical record system;Evidence based intervention;Face;federal policy;Feedback;Glucuronides;Goals;handheld mobile device;health management;Health Personnel;Health Services Accessibility;improved;Incentives;Individual;input device;Intervention;Location;Machine Learning;Maintenance;Managed Care;Maps;Measurement;Measures;Medicaid;Methodology;Methods;mobile application;mobile computing;Monitor;monitoring device;Moods;Morbidity - disease rate;mortality;novel;Outcome Measure;pandemic disease;Participant;patient engagement;Patients;Pattern;personalized intervention;Persons;portability;Provider;Randomized;randomized, clinical trials;Recovery;recruit;reduced alcohol use;Research;response;Rewards;Risk Factors;Rural;Rural Population;rural setting;Sampling;screening;sound;standard of care;System;Technology;telehealth;Testing;Time;tool;Transportation;treatment as usual;Universities;visual feedback;Washington

PROJECT_TITLE: Advanced Contingency Management System for Reduction of Alcohol Use.


NIH_SPENDING_CATS: Aging;Nutrition;Osteoporosis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Osteoporosis and low bone mass (i.e., osteopenia) are major public health problems affecting a staggering 54 million people in the U.S., and nearly half of all adults age 50 and older. This project will provide novel insight in to the cellular and molecular mechanisms by which parathyroid hormone (PTH) and/ or PTH related protein’s (PTHrP) stimulate bone formation via regulation of lipid metabolism.

PI_NAMEs: RENDINA-RUEDY, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adenosine Diphosphate;Adenosine Monophosphate;Adenosine Triphosphate;Adipocytes;Adipose tissue;Adult;Adverse event;Affect;Age;Anabolic Agents;Animal Model;Area;Bioenergetics;bone;Bone Formation Stimulation;bone health;Bone Marrow;bone mass;Buffers;Calcium;Caloric Restriction;Cells;Charge;Collagen Type I;combat;comorbidity;comparison control;Compensation;Data;Dependence;design;Development;experimental study;fatty acid oxidation;Fatty Acids;FDA approved;Femur;Financial Hardship;flexibility;Forteo;Fracture;Genus Hippocampus;Goals;Health;High Pressure Liquid Chromatography;hormonal signals;Hormone use;improved;In Vitro;in vivo;insight;Laboratories;Late-Onset Disorder;lipid metabolism;Lipids;Lipolysis;liquid chromatography mass spectrometry;Longevity;Measures;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;model design;Molecular;Monitor;mouse model;Mus;Nonesterified Fatty Acids;novel;Oleic Acids;Operative Surgical Procedures;Osteoblasts;Osteogenesis;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;Outcome;Outcome Study;Ovariectomy;oxidation;Oxidative Phosphorylation;parathyroid hormone-related protein;Patients;Persons;Pharmaceutical Preparations;Phase;Population;primary outcome;Process;Production;Proteins;PTH gene;Public Health;Regulation;Respiration;response;side effect;skeletal;spine bone structure;Stromal Cells;Technology;Testing;Therapeutic;tibia;Up-Regulation;X-Ray Computed Tomography

PROJECT_TITLE: Parathyroid hormone (PTH) modulates lipid metabolism in the skeletal niche


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The molecular mechanisms of epilepsy remain elusive, but genetic epilepsy disorders can provide new insights. Mutations in SLC6A1 also known as GAT1 (GABA transporter 1) cause myoclonic astatic epilepsy, and deficiency of GAT1 function may be implicated in absence epilepsy, but how hypofunction of a GABA transporter leads to epilepsy and how to optimally treat the disorder remains unclear. The current proposal will close these gaps by establishing a novel zebrafish model of GAT1 hypofunction using genetic and pharmacologic approaches to address questions related to the pathogenesis of the disorder and by testing whether a novel in vitro fluorescence-mediated cell-based assay of GAT1 function can be used to identify positive modulators with therapeutic value.

PI_NAMEs: MCGRAW, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Absence Epilepsy;Acute;Address;Affect;anti-epileptic agents;Award;Biological Assay;Biology;Boston;Brain;Brain imaging;candidate identification;career;career development;Cells;Central Nervous System;Chronic;Clinical;Data;Development;Disease;Drug Screening;Epilepsy;extracellular;Fishes;Fluorescence;Functional disorder;Future;GABA Modulators;GABA transporter;GABA Transporter 1;gamma-Aminobutyric Acid;General Hospitals;Generalized Epilepsy;Genes;Genetic;Goals;Heterozygote;high throughput screening;Human;Human Cell Line;Impairment;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo evaluation;infancy;inhibitor;innovation;insight;Institution;interest;Intractable Epilepsy;Investigation;Kinetics;Knock-out;Knowledge;Larva;Lead;Light;loss of function;loss of function mutation;Massachusetts;Measures;Mediating;medical schools;Mentorship;Modeling;Molecular;Mutation;Myoclonic Astatic Epilepsies;Nature;nervous system development;Neurons;neurophysiology;novel;novel therapeutics;Pathogenesis;Patients;Pediatric Hospitals;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Physicians;Population;precision medicine;Predisposition;programs;Property;Reporter;Reporting;Research;Research Project Grants;Resistance;Resources;reuptake;Rodent;Role;Science;Scientist;screening;Seizures;sensor;Signal Transduction;Syndrome;System;Testing;Therapeutic;tiagabine;tool;Translational Research;uptake;Work;Zebrafish

PROJECT_TITLE: Developing a Zebrafish Model of Slc6a1/GAT1 Hypofunction and an In Vitro Assay to Identify Novel Treatments


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Projective Narrative Examining the key psychosocial factors related to cardiometabolic health in older Chinese Americans is a critical area for public health, as cardiovascular disease and diabetes are the leading causes of death among older Chinese Americans. This study aims to investigate the effect of psychosocial stressors on cardiometabolic health and the social and cultural factors that moderate these associations using a mixed- methods approach. Study results will inform future culturally-tailored public health interventions to promote cardiometabolic health for older Chinese Americans.

PI_NAMEs: JIANG, YANPING  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Adopted;Adverse effects;Affect;aged;anti-Asian;Area;Asian;Asian Americans;Asian population;Attenuated;Biological Markers;biopsychosocial;Blood;Blood Pressure;C-reactive protein;cardiometabolism;Cardiovascular Diseases;Cause of Death;Chinese;Chinese American;Data;design;Deterioration;Diabetes Mellitus;Disadvantaged;Ecological momentary assessment;Emotions;Equity;ethnic minority;Ethnic Origin;experience;Exposure to;Family;Fasting;Female;Future;Glucose;Grain;Health;health equity promotion;Heterogeneity;High Density Lipoprotein Cholesterol;high risk;Hydrocortisone;Hypertension;Hypertriglyceridemia;Immigrant;Immigration;Individual;Interleukin-6;Intervention;Interview;Knowledge;Language;Limited English Proficiency;low socioeconomic status;marginalization;Measures;member;Metabolic syndrome;Methods;metropolitan;Minority;Mission;Modeling;National Institute on Minority Health and Health Disparities;New York;Not Hispanic or Latino;novel;Participant;Penetration;physical conditioning;Population;positive emotional state;Process;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Public Health;public health intervention;racial discrimination;racial disparity;racism;Research;response;Risk Factors;Role;Salivary;Sampling;social;Social isolation;sociocultural determinant;Socioeconomic Status;Stereotyping;Stress;Structure;Symptoms;systemic inflammatory response;Testing;Time;Treatment/Psychosocial Effects;Underserved Population;United States;waist circumference

PROJECT_TITLE: Daily psychosocial stress and cardiometabolic health of older Chinese Americans

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: The rapid advances in high-throughput biology and digital biomedicine as well as machine learning and data science technologies have created critical needs and an unprecedented opportunity to train the next generation of multidisciplinary researchers at the interface of biomedical and computational sciences. This new T32 predoctoral training program aims to enhance graduate research training in the areas of computational biology, bioinformatics, and biomedical data science. It will be a cross-campus program with a collaborative team science environment and evidence-based, reproducible, and responsible research conduct to ensure scientific rigor for transformative workforce development.

PI_NAMEs: POLSON, SHAWN W (contact);SINGH, ABHYUDAI ;WU, CATHY H.

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Bioinformatics;biomedical data science;Computational Biology;Training Programs

PROJECT_TITLE: Graduate Training Program in Computational Biology, Bioinformatics and Biomedical Data Science (CBB)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Disability Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pain Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The consequences of the COVID-19 pandemic on the well-being and functioning of vulnerable older adults are likely to be severe, yet we lack evidence for successful interventions to reduce these effects. We will test a program in which community health workers teach self-management and resilience-building skills to primarily African American older adults in a socioeconomically disadvantaged urban community. Because this group is at disproportionately high risk for poor functioning, this research aims to reduce the racial health disparities that are widening due to the pandemic and thereby enhance population health.

PI_NAMEs: JANEVIC, MARY ROSE (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adult;Affect;African American;Age;Anxiety;Behavioral;Biometry;Caring;Chronic;Chronic Disease;chronic pain;Cities;clinically significant;Cognitive;Collaborations;Communities;community advisory board;community center;community engagement;Community Health Aides;community led intervention;computer human interaction;COVID-19;COVID-19 impact;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;COVID-19 susceptibility;Crowding;daily functioning;Data;deconditioning;design;digital;Disablement;Disadvantaged;Discipline of Nursing;Disparity;Distress;Education;Educational Curriculum;Educational process of instructing;evidence base;Exclusion;experience;Face;Fatigue;functional outcomes;Goals;group intervention;Health;Health Services Needs;hearing impairment;High Prevalence;high risk;impression;improved;Individual;Inequity;innovation;Institutional Racism;Intervention;intervention participants;Life Cycle Stages;Link;marginalized community;marginalized population;Mental Depression;Mental Health;Methods;mHealth;Michigan;Modeling;Moods;older adult;Outcome;Pain;Pain interference;pandemic disease;pandemic impact;pandemic response;Participant;Patient Recruitments;Personal Satisfaction;Persons;Physical activity;physical conditioning;Physical environment;Physical Function;Physical Medicine;Physical Rehabilitation;physical symptom;Pilot Projects;pilot trial;podcast;Pollution;Population;population health;prevent;programs;promote resilience;psychologic;psychological symptom;Psychology;psychosocial;Public Health;racial health disparity;Randomized;Research;resilience;Resources;Safety;secondary outcome;Self Management;Series;Services;skills;Sleep;social;social engagement;Social isolation;Social support;Social Work;socioeconomic disadvantage;successful intervention;symptom management;Symptoms;Telephone;telephone session;Testing;tool;Underserved Population;uptake;Urban Community;Vulnerable Populations;wearable device;Work

PROJECT_TITLE: Improving Physical and Psychosocial Functioning in Underserved Older Adults During the COVID-19 Pandemic: A Community Health Worker-Led Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Transposable elements have been implicated in neurodegeration, including Alzheimer disease (AD). Recent genetic studies have highlighted the role of not only neurons but also microglia in the pathogenesis of AD. Therefore, to fully understand the biology of the disease there is a need to perform depth molecular characterization in a cell-specific manner. The overall goal of this proposal is to identify and characterize neuronal and microglia-specific TE and downstream (chromatin accessibility, transcript levels and new transcript) changes implicated on disease. Functional characterization of TE implicated in disease will also be instrumental to identify potential therapeutical targets.

PI_NAMEs: CRUCHAGA, CARLOS  (contact);FROST, BESS ;KARCH, CELESTE MARIE;WANG, TING ;YOO, ANDREW

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Adult;Affect;Age;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;amyloid precursor protein processing;ATAC-seq;Biological Models;Biology;Brain;brain cell;brain tissue;Cell model;cell type;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Complex;Data;Dementia;differential expression;Disease;DNA Methylation;DNA Transposable Elements;effective therapy;Event;extracellular;Fibroblasts;Functional disorder;Genes;Genetic;genetic element;Genetic study;Genetic Transcription;genetic variant;Genome;genome editing;Genomic approach;Genomic Instability;Genomics;Goals;healthy aging;Human;Human Genome;human model;Human Resources;human stem cells;immune function;Individual;induced pluripotent stem cell;Inflammation;interdisciplinary approach;knock-down;Lead;Location;Maps;Mediator;Microglia;Mobile Genetic Elements;Modeling;Molecular;Mutation;Nerve Degeneration;neuroinflammation;neuron loss;Neurons;novel;novel strategies;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;presenilin-1;presenilin-2;rare variant;Repetitive Sequence;response;risk variant;Role;Sampling;Senile Plaques;Small Interfering RNA;tau Proteins;tau-1;Tauopathies;therapeutic target;Tissue Model;Toxic effect;Transcript;transcriptome;transcriptome sequencing;transcriptomics;TREM2 gene;Variant

PROJECT_TITLE: Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Orphan Drug;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The incidence of Human Papilloma Virus (HPV)-associated cancers continues to rise, with 5% of all cancers worldwide being attributable to HPV, despite the implementation of the HPV vaccine. There is a significant difference in outcomes between, and within, HPV+ and HPV- cancers of the same site yet all patients are treated similarly. This project will define the chromosomal instability caused by HPV, and determine how chromosomal instability affects radiation sensitivity and the anti-tumoral immune response in order to define clinically relevant biomarkers for personalization of radiotherapy in cervical and head and neck cancers.

PI_NAMEs: COSPER, PIPPA F (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: adaptive immune response;adaptive immunity;advanced disease;Affect;alternative treatment;Aneuploidy;anti-tumor immune response;Award;Biological Markers;Biology;cancer cell;Cancer Model;Cancer Patient;Cell Death;Cell division;Cell Line;Cells;Cervical;chemoradiation;Chromosomal Instability;Chromosomal Stability;chromosome missegregation;chromosome number abnormality;Chromosomes;Clinical;clinically relevant;cohort;Data;DNA;Dose;Engineering;Environment;Epithelial Cells;Etiology;Event;Exhibits;Genotype;Glioma;Haploidy;Head and Neck Cancer;head and neck cancer patient;HPV negative;HPV positive;Human;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immune;Immune response;Immunocompetent;immunogenic;Immunologic Markers;Immunology;improved;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Innate Immune Response;insight;Interferon Type I;Ionizing radiation;keratinocyte;Laboratories;Length;Locally Advanced Malignant Neoplasm;Lymphocytic Infiltrate;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mentorship;Mitotic;Modeling;Morbidity - disease rate;Mus;Natural Immunity;novel;Oral;oral HPV-positive head and neck cancers;Oropharyngeal;Outcome;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;personalized biomarkers;personalized medicine;Platinum;Postdoctoral Fellow;predictive marker;Prognosis;Radiation;Radiation Oncology;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;Rectal Cancer;Recurrence;Research Personnel;Resources;response;Sampling;Site;skills;Source;standard of care;Stimulator of Interferon Genes;Testing;Time;Tonsil;Toxic effect;Training;Translating;Translational Research;treatment response;tumor;Tumor Biology;tumor growth;Tumor Immunity;tumor immunology;Tumor Promotion;Tumor Suppression;Universities;Viral;Viral Oncogene;virology;Wisconsin

PROJECT_TITLE: Chromosomal Instability as a Marker and Mechanism of Radiation Response

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: Protein misfolding is a key pathology in neurodegenerative diseases. This research will elucidate fundamental molecular and genetic mechanisms that cause neurodegeneration. This research may identify new ways to prevent neurodegenerative diseases by improving cellular protein quality.

PI_NAMEs: LIN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affect;Alleles;Apoptosis;Area;Arsenic;Autophagocytosis;Autopsy;Biochemical;Brain;Brain region;brain tissue;Cell Death;cell growth regulation;Cells;chemical association;Chemicals;Clinic;Clinical;Data;Degradation Pathway;Development;Dimerization;Disease;endoplasmic reticulum stress;Environment;environmental agent;environmental chemical;Environmental Monitoring;Environmental Risk Factor;Enzymes;epidemiology study;Exposure to;Firearms;Florida;Fruit;Genetic;genetic risk factor;Genetic Transcription;genome wide association study;Genotype;Goals;Heterozygote;Hippocampus;Histologic;Homeostasis;Human;human stem cell-derived;human stem cells;Impairment;improved;Ingestion;inhibitor;insight;Lead;Link;London;Mediating;Midbrain structure;misfolded protein;Molecular;Molecular Chaperones;multicatalytic endopeptidase complex;Neocortex;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neuron loss;Neuronal Differentiation;Neurons;neuropathology;novel therapeutic intervention;novel therapeutics;Occupational Exposure;Paint;Pathogenicity;Pathology;Patients;PERK kinase;Persons;pharmacologic;Phosphotransferases;polypeptide;prevent;programs;Progressive Supranuclear Palsy;Property;protein degradation;protein folding;protein misfolding;Protein-Serine-Threonine Kinases;Proteins;proteostasis;proteotoxicity;Recombinants;Research;Resistance;response;Risk;risk variant;Role;Serine;Signal Transduction;small molecule;Speed;stem cells;tau Proteins;Tauopathies;Testing;Therapeutic;Toxin;Transcription Initiation;transcriptome sequencing;Translations;well water

PROJECT_TITLE: Protein Homeostasis and Proteotoxicity Mechanisms

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE These studies will enhance our understanding of how a prevalent human pathogen establishes infection in its human host. The proposed research examines how cells communicate with each other using small vesicles that are produced by a parasite and are internalized by the host cell. As these extracellular vesicles (EVs) are also produced by mammalian cells and play critical roles in mammalian development, immune modulation and cancer metastasis, what is learned from these studies will contribute to a better understanding of the role of EVs in both homeostasis and disease.

PI_NAMEs: JOHNSON, PATRICIA JEAN (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Adherence;adverse pregnancy outcome;Affect;American;Annual Reports;Antigen Presentation;Binding;Biochemical;candidate validation;Case Study;Cell Communication;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Cervicitis;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Communication;Contracts;cytokine;Data;design;Development;Disease;Down-Regulation;Drug resistance;exosome;extracellular;extracellular vesicles;Future;Glycoside Hydrolases;Goals;Health;Helminths;Heparan Sulfate Proteoglycan;Heparitin Sulfate;HIV;Homeostasis;host colonization;Human;human pathogen;Immune;Immune response;immunoregulation;In Vitro;in vivo;Incidence;Infection;Inflammatory;insight;Knock-out;Knowledge;Learning;Leishmania;Ligands;male;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Mammalian Cell;Mass Spectrum Analysis;Mediating;Membrane;Molecular;mouse model;neglect;Neonatal Mortality;Neoplasm Metastasis;novel;novel therapeutic intervention;Outcome;Parasites;Parasitic infection;pathogen;Pathogenesis;Pelvic Inflammatory Disease;Persons;Pharmaceutical Preparations;Plasmodium;Play;Pregnancy Complications;Process;Property;Proteins;Proteomics;receptor;Reporting;Research;response;Risk;RNA;Role;Severities;Sexually Transmitted Diseases;Site;Testing;Therapeutic;Transferase;transmission process;Trichomonas Infections;Trichomonas vaginalis;Trypanosoma;uptake;Urethritis;Urogenital Cancer;urogenital tract;vaccine candidate;Vaccine Design;Vaginitis;Vesicle

PROJECT_TITLE: Identification of key players mediating internalization of Trichomonas vaginalis extracellular vesicles by host cells and parasite adherence and survival in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioids;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease;Telehealth

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Our long-term goal is to reduce stress and improve pain control with less opioid use in patients with sickle cell disease by promoting an intervention with self-management relaxation/distraction exercises, named You Cope, We Support (YCWS). Building on the successes of our prior formative studies to develop the intervention and study protocol, we now propose a well-designed, appropriately powered study to test effects of YCWS on stress, pain, and opioid use in adults with sickle cell disease. Findings will be useful for advancing the use of relaxation/distraction exercises in future intervention studies among patients with sickle cell disease.

PI_NAMEs: EZENWA, MIRIAM OMELEBELE (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Absenteeism;Acute;Acute Pain;Adult;American;Behavior Therapy;Caring;Cells;Characteristics;Chronic Disease;chronic pain;clinical pain;Clip;Cognitive Therapy;comparison control;Computers;Control Groups;coping;cost;Data;design;distraction;Dose;Education;efficacy outcomes;efficacy testing;Electronic Mail;Exercise;experience;experimental group;Family;Future;Goals;guided inquiry;Health;Health Care Costs;health care service utilization;Heterogeneity;Hour;Image;improved;improved outcome;Income;Individual;insight;Intervention;intervention effect;Intervention Studies;Interview;Life;Long-Term Effects;Machine Learning;Measurement;Methods;mHealth;Mobile Health Application;Modeling;Monitor;morphine equivalent;Names;Nature;Nonpharmacologic Therapy;Opioid;Opioid Analgesics;opioid sparing;opioid use;Oral;Outcome;outcome prediction;Outpatients;overdose death;Pain;Pain intensity;Pain management;pain self-management;Participant;Patient Recruitments;Patient-Focused Outcomes;Patients;poor health outcome;predictive modeling;primary outcome;Protocols documentation;Psychological Impact;Randomized;Randomized, Controlled Trials;recruit;Recurrence;Relaxation;Reporting;Research;Research Personnel;response;rumination;Schools;secondary outcome;Self Efficacy;Self Management;sex;Sickle Cell Anemia;side effect;Stress;stress reduction;stressor;success;Suggestion;Support System;System;Telephone;Testing;Text;Therapeutic Intervention;therapy design;Time;Vulnerable Populations;Work

PROJECT_TITLE: A Stress and Pain Self-management m-Health App for Adult Outpatients with Sickle Cell Disease

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative My team will tackle previously unexplored events in human peri-implantation development: apical polarization and lumenogenesis of epiblast cells to generate the epiblast cavity. Our mouse and hPSC-based systems allow a unique opportunity to elucidate the cellular and molecular properties underlying human epiblast cavity formation.

PI_NAMEs: TANIGUCHI, KENICHIRO  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Acceleration;Actins;Amino Acid Transport System L;Amino Acid Transporter;Apical;ascorbate;ATP phosphohydrolase;Automobile Driving;Basic Amino Acid Transport Systems;Biogenesis;Biological Models;Biology;Biotinylation;Carrier Proteins;CDC42 gene;CDK6-associated protein p18;Cell Aggregation;Cell Nucleus;Cell Polarity;Cells;cellular microvillus;Charge;Cilia;cilium biogenesis;Coupled;Cysteine;Cytoskeletal Modeling;Data;Development;Embryo;embryo tissue;Embryonic Development;Endoderm;Engineering;Epiblast;Epigenetic Process;Ethics;Event;experimental study;extracellular;Fertility;FRAP1 gene;Glutamate Transporter;Goals;Human;Human Development;human model;human pluripotent stem cell;Image;Implant;implantation;In Vitro;in vivo;Investigation;Link;Mass Spectrum Analysis;Membrane;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Names;natural Blastocyst Implantation;novel;Nuclear;Organelles;Peroxidases;polarized cell;Process;Property;Proteins;Proteome;Proteomics;Protons;Radial;Reproduction;Rosaniline Dyes;self organization;Signal Transduction;spheroids;Structure;Subcellular structure;Surface;System;tool;trafficking;transcriptomics;trophoblast;Uterus;Vesicle;Work

PROJECT_TITLE: Mechanism of apicosome-driven lumen formation during human and mouse embryogenesis

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: Project Narrative  Regular exercise is associated with slower declines in mobility and quality of life in people with Parkinson’s disease, but most people with Parkinson’s do not achieve recommended levels of exercise. Research is needed to determine the best ways to facilitate physical activity and exercise initiation, progression, and maintenance in Parkinson’s and other chronic health conditions. The proposed project evaluates how a consultative model of physical therapy can promote changes in exercise behaviors, as well as the individual, clinical, organization, and community-level factors required to implement and scale this model of care.

PI_NAMEs: RAFFERTY, MIRIAM ROSE (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Academic Medical Centers;Academy;Accelerometer;Address;Administrator;Adoption;Aerobic;Aerobic Exercise;American;Behavior;Caring;Child Health;Chronic;Clinical;Communities;Community Hospitals;community-level factor;Diagnosis;disability;Disabled Persons;disease diagnosis;disorder control;Effectiveness;effectiveness measure;effectiveness/implementation hybrid;effectiveness/implementation trial;Enrollment;Equilibrium;Equity;Evaluation;Exercise;exercise intervention;exercise prescription;exercise regimen;expectation;experience;fear of falling;fitness;flexibility;formative assessment;functional gain;Future;Goals;Guidelines;Health;health care service;Hour;Human Development;implementation determinants;implementation facilitation;implementation outcomes;implementation strategy;improved;Individual;interest;Intervention;Interview;Low income;Maintenance;Measures;Medical;Mobility decline;Modeling;Monitor;mortality;Neurologist;Neurology;Outcome;Parkinson Disease;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Perception;Persons;Physical activity;Physical Exercise;Physical Function;physical model;Physical therapy;Population;Practice Guidelines;processing speed;programs;provider adoption;Quality of life;Questionnaires;Recommendation;Rehabilitation therapy;Reporting;Research;research and development;Resource-limited setting;Resources;Severity of illness;Site;social health determinants;standard care;Structure;suburb;Symptoms;Testing;Therapeutic Intervention;therapeutically effective;Time;traditional therapy;United States National Institutes of Health;urban area;verbal;vigorous intensity;Visit;Work;Writing

PROJECT_TITLE: Consultative Physical Therapy: A Physical Activity and Exercise Implementation Strategy in Parkinson's

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE In humans, some of the light-derived visual information leaving the eye processed in specific ways to mediate critical functions, including programming the circadian clock and controlling eye movement. Understanding the regions of the brain which receive, process, and transmit this non-image-forming visual information is a critical step in understanding and addressing the health issues which arising from their dysfunction, including jet-lag, sleep disorders, depression, and visuomotor disorders.

PI_NAMEs: SABBAGH, UBADAH  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Architecture;Area;Biological Clocks;Biology;Brain;BRAIN initiative;Brain region;Cell Nucleus;cell type;Cells;Characteristics;circadian;circadian pacemaker;Classification;Communities;Data;Data Set;Development;developmental neurobiology;Disease;doctoral student;Dorsal;Extracellular Matrix;Eye;Eye diseases;Eye Movements;Fiber;Functional disorder;Genetic;Goals;Health;Human;Image;Immunohistochemistry;In Situ Hybridization;Individual;information processing;Injury;innovation;interdisciplinary approach;Jet Lag Syndrome;Knowledge;Label;Laboratories;Lateral Geniculate Body;Lead;Light;Maps;Mediating;Medicine;meetings;Mental Depression;Mentors;Molecular;Molecular Neurobiology;Moods;National Eye Institute;Natural regeneration;Nerve Regeneration;Nervous System;neural circuit;neurochemistry;neurodevelopment;Neurons;Neurosciences;novel;optic nerve regeneration;Pattern;Positioning Attribute;Postdoctoral Fellow;postnatal;pre-doctoral;Process;programs;Proteome;Proteomics;Publications;regenerative approach;regenerative therapy;Reporter Genes;Research;Research Methodology;Research Personnel;Research Project Grants;restoration;Retina;Retinal Ganglion Cells;retinogeniculate;Role;segregation;single-cell RNA sequencing;Sleep Disorders;Spatial Distribution;Structure;Subthalamic structure;System;Technical Expertise;tenure track;Testing;Thalamic structure;therapy development;tool;Training;transcriptome;transcriptomics;Transgenic Organisms;Translational Research;transmission process;United States National Institutes of Health;Universities;Vestibular function;Viral;Virginia;Vision;vision development;Visual;visual information;visual motor;Visual System;Work

PROJECT_TITLE: The development of subnetworks of the TRN


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: DERMATOLOGY

PHR: Relevance to Public Health This Future Academic Scientists in Dermatology (FASID) program will provide young MD, MD-PhD and PhD investigators with the training, mentoring and skills that are necessary to become the next generation of full- time basic science and clinical researchers and scientific leaders in dermatology. The proposal is significant because skin diseases represent a broad range of inflammatory, autoimmune and genetic disorders as well as cutaneous malignancies, which are major challenges to public health due to their frequency, disfigurement, morbidity and mortality. It is crucial to develop future translational researchers in dermatology to more effectively translate basic science discoveries in skin biology into new diagnostic and therapeutic approaches to improve the care of patients suffering from skin diseases.

PI_NAMEs: GARZA, LUIS ANDRES (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Dermatology;Future;Scientist


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Using a novel data source that provides information on the timing of skilled nursing facilities’ participation in health information exchange, this will be the first large-scale study to quantify the impact of health information exchange participation among these facilities on the quality and cost of care for patients with Alzheimer’s disease or related dementias (ADRD). It will also be the first study to quantify the impact of skilled nursing facilities’ participation in health information exchange on disparities in the quality of care associated with income and race among ADRD patients.

PI_NAMEs: UNRUH, MARK AARON (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: acute care;Address;Admission activity;Adoption;Adverse event;adverse outcome;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Back;beneficiary;care coordination;care costs;care fragmentation;Caring;Characteristics;Chronic;Clinical;Communities;cost;Cost Savings;Data;Data Element;Data Sources;Diagnosis;Discipline of Nursing;Disparity;disparity reduction;dual eligible;Etiology;Event;Face;Fee-for-Service Plans;Frequencies;functional improvement;Health;Health Care Costs;health information technology;Health Promotion;Home;hospital readmission;Hospitalization;Hospitals;improved;incentive program;Incentives;Income;income disparities;Individual;information organization;Investigation;Length of Stay;Measures;Medical center;Medicare;Medicare claim;Medicare/Medicaid;mortality;New York;novel;Outcome;Patient Care;Patient Discharge;Patient-Focused Outcomes;Patients;payment;Pharmaceutical Preparations;Physicians;Policy Maker;Population;prevent;Provider;Quality of Care;Race;racial disparity;racial minority;readmission rates;Research;Research Design;Research Priority;residence;Sampling;Skilled Nursing Facilities;Symptoms;Variant

PROJECT_TITLE: Skilled Nursing Facility Participation in Health Information Exchange and Quality of Care for Patients with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE – Public Health Relevance Ischemic stroke – a major public health burden – is frequently complicated by brain swelling that can worsen neurological outcome and cause death. Aquaporin-4 has been causally linked to brain edema and brain swelling but our ability to regulate aquaporin-4 function to reduce edema remains elusive. Using a mouse model of ischemic stroke, combined with molecular and genetic techniques, we will study perivascular astrocyte endfeet to determine the role of Na+/Ca2+ exchanger 1 in regulating aquaporin-4 function, and to identify novel druggable targets for brain swelling.

PI_NAMEs: SIMARD, J. MARC  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: aquaporin 4;Astrocytes;Binding;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Edema;Brain Ischemia;brain tissue;Calmodulin;Cause of Death;Cell surface;Clinical Trials;Cultured Cells;Data;Development;Diazoxide;Edema;Elements;Evans blue stain;experimental study;Female;Genetic Techniques;Glial Fibrillary Acidic Protein;Glyburide;Hour;Image;in vivo;inhibitor;Ischemia;Ischemic Stroke;Knowledge;Laboratories;Link;male;Measures;Mediating;Membrane;Methods;Middle Cerebral Artery Occlusion;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Neurological outcome;new therapeutic target;novel;Osmosis;Pathway interactions;pharmacologic;Play;pre-clinical;Public Health;public health relevance;receptor;Regulation;Reperfusion Therapy;Reporting;Role;Science;Seminal;Signal Transduction;Slice;sulfonylurea receptor;Surface;Swelling;theories;tool;transgene expression;translational potential;Water;Work

PROJECT_TITLE: Aquaporin-4 regulation by NCX1 in post-ischemic brain swelling

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The outcome of the proposed project will have a significant impact on our understanding of the neural basis of episodic memory in rodents, nonhuman primates and humans and how specific brain regions contribute to age-associated memory deficits. This is a prerequisite for successful development of therapeutic or preventative treatments for cognitive decline in the elderly, and will provide new approaches to studying, and ultimately ameliorating, memory disorders arising from other sources, such as developmental disorders, stress, drug abuse, brain trauma or neurodegenerative disease.

PI_NAMEs: BARNES, CAROL A. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adaptive Behaviors;Address;Age;age effect;age group;age related;age related changes;Age-associated memory impairment;aged;Aging;aging brain;analog;Anatomy;Animals;Back;Behavior;Behavior Control;Behavioral;Behavioral Assay;Biochemical Pathway;Biological;Biological Aging;Brain;Brain region;Cells;Characteristics;Code;Cognition;Cognitive deficits;Communication;Complement;Critical Pathways;Cues;Data;density;design;Development;developmental disease;Drug abuse;Elderly;Electrophysiology (science);entorhinal cortex;Environment;Episodic memory;Experimental Designs;experimental study;Failure;Feedback;Freedom;Functional Magnetic Resonance Imaging;Goals;Head;Head Movements;Health;high resolution imaging;Hippocampus;Human;imaging modality;Impaired cognition;Impairment;Individual;Individual Differences;juvenile animal;Life;Link;Locomotion;Macaca;Mammals;Maps;Measurement;Measures;Medial;Memory;Memory Disorders;Memory impairment;Methodology;Methods;Modeling;Molecular;Monitor;Monkeys;Motivation;Movement;neural;neural circuit;neurobehavioral;Neurodegenerative Disorders;Neurons;nonhuman primate;novel;novel strategies;older adult;optic flow;Outcome;Output;Participant;Pattern;Preventive treatment;Primates;programs;Property;Rattus;Research;resilience;Resolution;Rest;restraint;Retrieval;Rodent;Rotation;Running;senescence;sensory input;Signal Transduction;Slow-Wave Sleep;Source;Spatial Behavior;Specificity;Stress;Structure;success;Synapses;System;Technology;Testing;therapeutic development;tool;Translating;Traumatic Brain Injury;Update;vestibular system;virtual reality;virtual reality environment;wireless;young adult

PROJECT_TITLE: Neurobehavioral Relations in Senescent Hippocampus

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE The Women’s Reproductive Health Research Career Development Program at the University of North Carolina at Chapel Hill (the UNC WRHR Program) supports promising obstetrician-gynecologists during an important stage in their professional advancement. The program provides the dedicated effort, mentorship, and structured career development activities needed to support their transition to research independence. UNC WRHR scholars conduct cutting-edge research to advance women’s reproductive health—domestically and globally—in a vibrant and fostering research environment.

PI_NAMEs: NEAL-PERRY, GENEVIEVE S. (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Address;Area;Award;Cardiometabolic Disease;career;career development;clinical practice;clinically relevant;Collaborations;Communities;Cost Sharing;curriculum development;design;Discipline of Nursing;Ensure;Environment;experience;Faculty;faculty mentor;Foundations;Funding;Goals;Gynecologist;Individual;Institution;Learning;medical schools;medical specialties;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mood Disorders;next generation;North Carolina;Obesity;peer;Pharmacy facility;Play;Pregnancy Complications;Program Development;programs;Public Health;Research;Research Personnel;Resources;risk minimization;Role;sexual and reproductive health;Social Work;Structure;substance use;success;Time;Translating;United States National Institutes of Health;Universities;Wages;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Advancing womens health through research: the UNC WRHR Career Development Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Most people who experience a heart attack eventually develop heart failure. This is mainly due to an abnormal inflammatory response driven by neutrophils and sub-optimal wound healing. In this grant, we propose to study the role of neutrophils, the cells that infiltrate the injured heart immediately after heart attack, in would healing.

PI_NAMEs: NAGAREDDY, PRABHAKARA REDDY (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Acceleration;Acute;Agonist;Anti-Inflammatory Agents;Antibodies;Cardiac;Cause of Death;CD36 gene;Cell Line;cell type;Cells;Cessation of life;Clinical;Cytometry;defined contribution;Early Intervention;Excision;Exhibits;experience;Exposure to;Fluorescence;genetic approach;Grant;healing;Heart;Heart failure;heart function;Heart Injuries;improved;improved outcome;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Knowledge;Label;Leukocytes;Macrophage;Maps;Mediating;Molecular;monocyte;Mus;Myocardial Infarction;myocardial injury;neutrophil;Neutrophil Infiltration;NF-kappa B;novel;Outcome;paracrine;Pathway interactions;Patients;Pattern;Persons;phagocytosis receptor;pharmacologic;Phase;Phenocopy;Phenotype;Play;programs;PTPRC gene;receptor expression;Receptor Signaling;Recombinants;Reporter;Reporting;Resolution;Role;RXR;S100A8 gene;scavenger receptor;Scheme;Signal Transduction;single-cell RNA sequencing;Sorting;SR-A proteins;System;Tamoxifen;Testing;Time;tissue repair;Toll-like receptors;transcriptome sequencing;transcriptomics;Up-Regulation;uptake;wound healing

PROJECT_TITLE: A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injury

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative  Epigenetic mechanisms refer to regulatory processes in cells and organisms that control heritable information other than the DNA sequence, and recent research has highlighted a key role of epigenetic regulation in determining how long an organism lives and whether that information is passed onto its offspring. This application proposes to use the powerful genetic model C. elegans to investigate the mystery of how epigenetic regulation influences longevity and its inheritance. The findings from this proposal will provide important insights into the basic biology of aging and may inspire future therapeutic development that aims to promote healthy aging and alleviate age-related diseases.

PI_NAMEs: LEE, SIU SYLVIA  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;age related changes;age-related disease;aged;Aging;Binding;Biological;biological adaptation to stress;Biological Phenomena;Biology of Aging;Caenorhabditis elegans;cell age;Cells;Characteristics;Chromatin;Chromatin Remodeling Factor;Chromosome Arm;Chronic stress;cofactor;Collaborations;Communities;Complex;Coupled;Data;Development;DNA Methylation;DNA Sequence;Environment;environmental intervention;environmental stressor;Epigenetic Process;epigenetic regulation;experience;Exposure to;extend lifespan;Future;Gene Expression;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;genomic data;Genomics;Goals;Health;healthy aging;Heritability;Heterochromatin;histone modification;Histones;Homologous Gene;host cell factor C1;improved;Inherited;insight;Investigation;Life;life span;Link;Longevity;Longevity Pathway;Lysine;Memory;Methylation;Methyltransferase;Modeling;Modification;Molecular;mutant;offspring;Organism;Pattern;Physiologic pulse;Physiological;Process;programs;promoter;protective effect;protein complex;Proteins;proteostasis;Reader;recruit;Research;Resistance;Resources;RNA Interference;Role;Site;Somatic Cell;Stress;Techniques;Testing;therapeutic development;Tissues;transcription factor;transgenerational epigenetic inheritance;Untranslated RNA

PROJECT_TITLE: Genetic and Epigenetic Determinants of Longevity

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE Community-level contextual factors (i.e. built and social environments) are important yet underappreciated social determinants of Alzheimer's disease and related dementias (ADRD). To effectively reduce the risk of ADRD and related health disparities, we need to understand how community-level contextual factors across the lifecourse shape late-life cognitive/brain health, and if the effects are mediated through health behaviors that are protective against ADRD. Findings from the proposed research are critical for advancing population based ADRD risk reduction strategies that eliminate, rather than exacerbate, health disparities.

PI_NAMEs: PETERSON, RACHEL LYNNE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Affect;Age;aging brain;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Area;Asian population;Atlases;Award;Behavior Therapy;Behavioral;Biological Factors;Birth History;Black Populations;Brain;brain health;built environment;California;cardiometabolism;career;Censuses;Childhood;Clinical Trials;Cognition;Cognitive;cohort;Communities;community center;contextual factors;County;Data;Databases;Dementia;dementia risk;deprivation;Diet;Disparity;Dose;Economics;Epidemiology;Ethnic Origin;Exposure to;Failure;farmers markets;Funding;Future;Gender;Geography;Goals;Green space;Health;Health behavior;Health Benefit;health disparity;Health Promotion;healthy aging;Hippocampus;Impaired cognition;indexing;Individual;Influentials;innovation;insight;International;late life;Latino Population;Libraries;Life Cycle Stages;Life Experience;Life Style;Link;Magnetic Resonance Imaging;Measures;Mediating;Mentorship;Methods;Modeling;modifiable risk;neighborhood disadvantage;Neighborhoods;neuroimaging;neuroimaging marker;Observational Study;Outcome;Participant;Pathway interactions;Physical activity;physical inactivity;Play;Policies;Population;population based;Population Intervention;Positron-Emission Tomography;protective behavior;psychologic;Public Health;Race;racial difference;Research;response;Risk Factors;Risk Reduction;Science;Shapes;social;social determinants;Social Environment;social epidemiology;social health determinants;Socioeconomic Status;socioeconomics;Testing;Training;Translating;United States National Institutes of Health;Universities;walkability;Work

PROJECT_TITLE: Lifecourse Community Contexts and Health Behaviors as Drivers of Disparities in Risk of Alzheimer's Disease and Related Dementias

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Prion diseases are fatal neurodegenerative disorders of humans and animals that pose a grave threat to public health, and endanger the safety of the food, blood and organ supplies. This grant application explores the mechanisms by which prions damage nerve cells and their connections. The project sets the stage for development of novel therapeutic approaches based on blocking specific neurotoxic pathways, and it will enhance understanding of other, more common neurodegenerative disorders such as Alzheimer's disease.

PI_NAMEs: HARRIS, DAVID A (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's Disease;Amino Acids;Amyloid beta-Protein;Animals;Applications Grants;Binding;Biological;Biological Assay;Blood;Brain;C-terminal;calmodulin-dependent protein kinase II;Cell surface;Cells;cellular targeting;Chemicals;Combined Modality Therapy;crosslink;Cytoplasm;design;Development;Disease;Docking;Drug Targeting;Enzymes;flexibility;Food Safety;Frontotemporal Dementia;Functional disorder;Generations;Genetic Transcription;Genomics;glycogen synthase kinase 3 beta;Goals;Grant;Human;Infection;insight;Knowledge;Label;Ligands;Lipids;Mass Spectrum Analysis;Mediating;Membrane;Modeling;Molecular;Morphology;Mus;N-terminal;nerve damage;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Organ;p38 MAPK Signaling Pathway;Parkinson Disease;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;PIK3CG gene;Prion Diseases;Prions;Process;Property;protein aggregation;Protein Kinase;Protein Kinase C;Proteins;PrP;PrPSc Proteins;Public Health;receptor;receptor binding;Role;sigma-1 receptor;Signal Pathway;Signal Transduction;Structure;superresolution microscopy;Synapses;Synaptic Transmission;System;tau Proteins;Tauopathies;Technology;Testing;Therapeutic;Toxic effect;Transgenic Model;Work

PROJECT_TITLE: Mechanisms of Prion Protein Toxicity


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Existing studies suggest that enhanced and prolonged myofilament force generation may be a major physiological cause underlying hypertrophic cardiomyopathy (HCM), but the mechano-signaling cascades through which the heightened sarcomeric force generation is sensed at the sarcomere and leads to abnormal nuclear hypertrophic signaling remains poorly understood. Patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC- CMs) and functional engineered heart tissues (EHTs) have provided a robust human cardiomyocyte-based system for studying the mechanobiology of HCM. This project details our current and future efforts to extensively investigate a novel biomechanical mechanism illuminating how dysregulated sarcomeric force production is sensed and leads to pathological signaling, remodeling, and hypertrophic responses, which will establish the foundation for developing innovative mechanism-based treatments for HCM that stabilize the Z-disc mechanosensory complex.

PI_NAMEs: QYANG, YIBING  (contact)

PROJECT_TERMS: 3 year old;Actins;Actomyosin;Affect;Affinity;Autophagocytosis;beta-Myosin;Biomechanics;Bioreactors;Calcineurin;Calcineurin inhibitor;Calcium;Calpain;Cardiac;Cardiac Myocytes;Cardiac Myosins;cardiac tissue engineering;Complex;Computer Models;Coupled;design;Development;Diastole;disease phenotype;Disinhibition;Event;Extracellular Matrix;Familial Hypertrophic Cardiomyopathy;Fiber;Fibroblasts;Foundations;Future;Generations;Genes;Genetic;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Heterozygote;Human;human disease;Hyperactivity;Hypertrophic Cardiomyopathy;Hypertrophy;Impairment;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;innovation;insight;Intervention;Investigation;Lasers;Left;Left Ventricular Hypertrophy;Length;Lysosomes;male;mechanical properties;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Microfilaments;Molecular;mouse model;multicatalytic endopeptidase complex;Muscle;Muscle Contraction;muscle LIM protein;mutant;Mutation;Myocardial dysfunction;Myocardium;Myosin ATPase;Myosin Heavy Chains;Nonsense Codon;novel;novel strategies;novel therapeutics;Nuclear;nuclear factors of activated T-cells;Obstruction;Parents;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Persons;pharmacologic;Phenotype;Physiological;Point Mutation;PPP3CA gene;prevent;proband;Production;protein degradation;Protein Isoforms;Proteins;recruit;Relaxation;Repression;response;Rodent;Role;Sarcomeres;scaffold;Signal Transduction;skin biopsy;Somatic Cell;Stem Cell Factor;Stress;Stretching;sudden cardiac death;System;Systole;T-Cell Activation;Testing;Tissues;transmission process;Ubiquitin;Ventricular

PROJECT_TITLE: Modulation of heart function by Muscle LIM protein-mediated mechanotransduction

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Public Health Statement Viral infection poses a major challenge to global health as demonstrated in the recent pandemics of H1N1 influenza virus, SARS and HIV. The goal of the current proposal is to understand the molecular mechanisms of viral recognition and regulation by MDA5 and TRIM65, which together constitute one of the principle innate immune pathways. These signaling pathways have been also implicated in pathogenesis of several autoimmune and inflammatory diseases, and were proposed to be a potential therapeutic target in anticancer immunotherapies.

PI_NAMEs: HUR, SUN  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Affinity;Agonist;Attention;Autoimmune Diseases;Binding;Biochemical;cancer immunotherapy;cancer therapy;Cells;Collaborations;Complex;Data;Discrimination;Disease;DNA Methyltransferase Inhibitor;Double-Stranded RNA;Event;Filament;global health;Goals;Grant;HIV;human disease;immune function;Immune response;Immune signaling;Immunologic Receptors;Infection;Inflammation;Inflammatory;Influenza A Virus, H1N1 Subtype;influenzavirus;innate immune pathways;Ionizing radiation;Ligands;Link;Mediating;Methods;Modeling;Molecular;Molecular Conformation;novel;novel therapeutic intervention;pandemic disease;Pathogenesis;Physiological;Play;Process;Public Health;receptor;Regulation;Repression;Research;RNA;Role;Severe Acute Respiratory Syndrome;Signal Pathway;Signal Transduction;Sterility;Therapeutic;therapeutic target;Time;ubiquitin-protein ligase;Viral;viral detection;viral RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Molecular mechanisms for antiviral signaling and regulation by MDA5 and TRIM65


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: The Northwestern University Medical Scientist Training Program prepares students for exciting and rewarding careers that combine biomedical investigation with the art of clinical medicine. Through an integrated, seven-to-eight year course of study, MSTP students develop the research, clinical, and professional skills required to pursue diverse career paths in the biomedical workforce, including positions in academia, industry, and federal agencies.

PI_NAMEs: HAUSER, ALAN R (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: MUANG

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: BOROMARAJONANI COLLEGE OF NURSING KHON KAEN

PHR: Project Narrative This innovative intervention research project addresses intimate partner violence (IPV), a critical public health issue globally and in Thailand, by rigorously developing and testing a culturally-appropriate mHealth intervention for Thai friends/family of IPV survivors, who are the most commonly-used sources of help for survivors. The intervention, a private, accessible app available by smartphone/browser (myPlan Thailand for Friends/Family) will empower friends/family of Thai IPV survivors by addressing IPV knowledge regarding IPV dynamics, myths, and community resources, provide strategies to support IPV survivors/self, and reducing distress and frustration related to supporting a survivor.

PI_NAMEs: UDMUANGPIA, TIPPARAT  (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Anger;Attitude;Australia;Award;Awareness;Battered Women;Benefits and Risks;Canada;career;career development;career networking;Cellular Phone;Child;Cognitive;Collaborations;college;Communities;Conflict (Psychology);Control Groups;Country;Dangerousness;Data;Data Collection;design;Development Plans;Discipline;Discipline of Nursing;Distress;Effectiveness;empowerment;Evidence based intervention;experience;Family;Family member;feasibility testing;Female;Fogarty International Center;follow-up;Friends;Frustration;Hand;Health;help-seeking behavior;improved;Income;informal support;innovation;instructor;Internet;Intervention;Intervention Studies;Interview;intimate partner violence;Jealousy;Kenya;Knowledge;Leadership;Learning;Linguistics;Link;Love;Low income;Maryland;Mental Depression;Mentors;Methodology;Methods;mhealth interventions;Minority;New Zealand;Participant;Patient Recruitments;Peer Review;Personal Satisfaction;Phase;pilot test;Positioning Attribute;prevent;primary outcome;Privatization;Procedures;psychologic;Public Health;Publications;Quality of life;Randomized;recruit;relationship abuse;reproductive coercion;Research;Research Personnel;Research Project Grants;research study;Resources;response;retention rate;Role;Safety;Sampling;secondary outcome;Secure;Series;Services;skills;social norm;Social support;Source;Study Section;suicidal;suicidal risk;support network;Support System;Survivors;Techniques;Technology;Testing;Thailand;Time;Training;treatment as usual;United States;Universities;Violence;web app;Well in self;Woman;women's outcomes;Work

PROJECT_TITLE: Cultural Adaptation of a Web-Based App (myPlan Thailand) to Empower and Support Friends and Family of Intimate Partner Violence Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_DEPT: PHARMACOLOGY

PHR: Injury to the cornea can be painful and compromise vision, especially in people with diabetes. For a cornea to heal cells need to talk to one another using signals from proteins that act like sensors, a process that does not work well in diabetic corneas. The goal of this proposal is to look at the interactions between two important sensing proteins to see why cells have a hard time talking to each other in diabetes.

PI_NAMEs: SEGARS, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Actins;Address;Affect;Agonist;Anterior;Biological Assay;Blindness;Bundling;Calcium Signaling;Cell Communication;Cell Culture Techniques;cell motility;Cell surface;Cells;Characteristics;Communication;Complication;Computer Analysis;Control Groups;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;Cytoskeletal Proteins;Cytoskeleton;Data;Defect;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic ulcer;Diffuse;Electron Microscopy;Epithelium;Etiology;Event;experience;Eye;Functional disorder;Generations;Goals;Golgi Apparatus;healing;Human;Impaired wound healing;injured;Injury;intercellular communication;Ion Channel;Keratoplasty;knock-down;Knowledge;Ligation;Machine Learning;Messenger RNA;migration;Modeling;mouse model;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Pain;Patients;Pattern;Persons;Phenotype;Population;Prediabetes syndrome;Probability;Procedures;Process;programs;Proteins;Purinoceptor;Recurrence;Regulation;response;Rest;Risk;Role;Sampling;sensor;Severity of illness;Signal Pathway;Signal Transduction;Signaling Protein;stem cells;Surface;symptomatic improvement;System;Time;trafficking;Translations;Travel;trend;Type 2 diabetic;Ulcer;Vision;wound;wound closure;wound healing

PROJECT_TITLE: Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Patients with the most prevalent hormone receptor positive (HR+) BCa subtype are frequently unresponsive to conventional endocrine therapy (ET) due to an increase in androgen receptor (AR) levels. We now report that a unique constitutively active AR drives ET-resistant HR+ BCa progression but is insensitive to the anti- androgen Enzalutamide currently in clinical trials. The current study will delineate how this “unique” AR functions, design more effective treatment for HR+ BCa, and increase the repertoire of targeted therapy for other AR-driven diseases.

PI_NAMEs: BAWA-KHALFE, TASNEEM  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: advanced breast cancer;Androgen Antagonists;Androgen Receptor;androgen sensitive;Androgens;antagonist;AR gene;Binding;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;Cancer Model;cancer subtypes;Cell Physiology;Chemosensitization;Chromatin;Clinical Trials;clinically relevant;Data;design;Disease;effective therapy;Endocrine;enzalutamide;Enzymes;Exhibits;genetic signature;Genetic Transcription;Genomics;Growth;hormone receptor-positive;hormone therapy;HSPB1 gene;improved;inhibitor;innovation;knock-down;Laboratories;Ligands;Ligase;Malignant Breast Neoplasm;Malignant Neoplasms;migration;mimetics;Molecular Chaperones;Mus;Neoplasm Metastasis;novel;novel marker;novel therapeutics;Nuclear;Oncogenes;overexpression;Patients;Phosphorylation;Pilot Projects;Post-Translational Protein Processing;prevent;Process;Proliferating;Property;Proteins;Qualifying;receptor;receptor binding;receptor function;recruit;refractory cancer;Reporting;Research Personnel;Resistance;responders and non-responders;response;RNA Binding;RNA Recognition Motif;Role;Small Ubiquitin-Related Modifier Proteins;spheroids;Sumoylation Pathway;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapy resistant;tool;transcriptome;translational study;Tumor Escape;tumor growth;tumorigenesis;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase

PROJECT_TITLE: Targeting Constitutively Active SUMO Modified Androgen Receptors in Endocrine Resistant Breast Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Clinical Research;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rehabilitation;Stroke;Unintentional Childhood Injury

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Perinatal stroke may lead to the secondary diagnosis of cerebral palsy and life-long movement impairment. By studying processes of early brain recovery and how recovery is related to brain development and movement in the first two years of life, we can develop effective, early treatments for infants with perinatal stroke. Minimizing future disability through early interventions would greatly improve quality of life and reduce burden on children and families.

PI_NAMEs: GILLICK, BERNADETTE THERESE (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: 2 year old;Adult;Affect;Age;Age Months;Behavior assessment;Behavioral;Brain;Caring;Cerebral cortex;Cerebral Palsy;Child;Childhood;Classification;Clinical;Contralateral;Corticospinal Tracts;Data;design;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;disability;Early Diagnosis;Early Intervention;Early treatment;Experimental Designs;Family;functional outcomes;Future;Goals;Heterogeneity;Human;Impairment;improved;Individual;infancy;Infant;Infant Development;Injury;Intervention;investigator training;Knowledge;Laboratories;Learning;Life;Manuals;Maps;Measures;Motor;Motor Cortex;Motor Evoked Potentials;motor impairment;motor recovery;Movement;multimodality;Natural regeneration;Neonatal Intensive Care Units;neuroimaging;Neurologic;Neuronal Plasticity;Newborn Infant;noninvasive brain stimulation;novel;Outcome;Parents;Pathway interactions;Pattern;perinatal stroke;Predictive Value;Process;prognostic;Quality of life;Recovery;recruit;Rehabilitation therapy;repaired;Research Design;safety and feasibility;Secondary to;Side;Stroke;Structure;System;Time;tool;tractography;Transcranial magnetic stimulation;Walking

PROJECT_TITLE: Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative This project will focus on Patient-Ventilator Asynchrony (PVA) in children through a prospective observational study in 3 pediatric ICUs, in addition to detailed analysis of existing data and data being gathered as part of an ongoing clinical trial which is testing a novel ventilator strategy. We will characterize the frequency and risk factors for common PVA subtypes in children, identify if PVA is independently associated with poor clinical outcomes and characterize the physiologic pathways which may be involved, and develop automated tools to improve the clinical recognition of PVA in children.

PI_NAMEs: KHEMANI, ROBINDER  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adult;Algorithms;Biological;Breathing;Child;Childhood;Clinical;Clinical Data;Clinical Decision Support Systems;Clinical Trials;cohort;Collection;Control Groups;Critically ill children;Data;Data Set;Delirium;Derivation procedure;Frequencies;Functional disorder;high risk;improved;Induction of neuromuscular blockade;infection risk;innovation;Intervention;Intervention Studies;Knowledge;Literature;Lung;Lung Diseases;lung injury;Machine Learning;machine learning model;Measures;Mechanical ventilation;Mechanical Ventilators;Mediating;Mediation;Methods;National Heart, Lung, and Blood Institute;neural;Neurocognitive;novel;novel diagnostics;novel therapeutic intervention;Observational Study;Outcome;Pathway interactions;patient subsets;Patients;Pediatric Research;Physiological;preclinical study;premature;prevent;Prevention;prospective;Randomized, Controlled Trials;Research Design;Research Personnel;respiratory;Respiratory Diaphragm;Risk;Risk Factors;secondary analysis;Sedation procedure;Strategic vision;Stress;Techniques;Testing;Therapeutic;tool;Training;treatment as usual;Validation;ventilation;Ventilator;Ventilator-induced lung injury

PROJECT_TITLE: Patient Ventilator Asynchrony in Critically Ill Children

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Myonemes are protein-based supramolecular springs that generate high power outputs in response to calcium, to enable rapid contractile motion in some protozoan cells. This project will utilize biophysical techniques to uncover how these springs generate force and develop synthetic myonemes that can be triggered using light. Myonemes have tremendous potential as biosensors, drug-delivery devices and artificial cytoskeletons in synthetic cells, and this research will the groundwork for adapting these nanomachines to novel biomedical function.

PI_NAMEs: BHAMLA, SAAD  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Biophysical mechanism and synthetic engineering of optically-controlled Ca2+-powered supramolecular engines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Mutations in the gene encoding Gα-Interacting Protein, C-terminus 3 (GIPC3) are known to cause profound hearing loss in humans. This project explores the role of GIPC3 in mechanoelectrical transduction of mammalian cochlear hair cells. Therefore, the study may identify mechanistic causes of hearing loss in patients carrying specific GIPC3 mutations, potentially contributing to new clinical treatments.

PI_NAMEs: DRAGICH, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Actins;Auditory;Biochemical;career;CDH23 gene;Cell Survival;Cells;Cellular biology;Clinical Treatment;Cochlea;Confocal Microscopy;Data;deaf;deafness;density;Detection;Development;Electron Microscopy;Electrophysiology (science);Ensure;Environment;experimental study;extracellular;Future;Genes;Hair;Hair Cells;Hearing;hearing impairment;Height;Human;Image;In Vitro;inhibitor;Knock-out;Laboratories;Link;Liquid substance;Maintenance;Mechanics;mechanotransduction;Methods;Microscopy;Modeling;Molecular;Motor;Mouse Strains;Mus;mutant;Mutation;MYO7A gene;Myosin ATPase;myosin VI;Outer Hair Cells;patch clamp;Patients;Phenotype;Physiological;Play;Preparation;Principal Investigator;protein function;Proteins;Research;response;Rest;Role;Shapes;skills;Slide;sound;Speed;Structure;Techniques

PROJECT_TITLE: Mechanisms of Tip Link Tensioning in Mammalian Auditory Hair Cells


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Every year, approximately 100,000 Veterans seek help at VA Audiology clinics for hearing and communication difficulties only to learn that they have normal hearing sensitivity. Unfortunately, there are very few established options to improve hearing and listening for these patients. To address this need, audiologists are increasingly prescribing hearing aids set to provide a small amount of amplification. Patients may benefit from the amplification or from modern hearing aid features such as noise reduction technology and the ability to stream sounds from a desired sound source directly to their ears thus reducing the background noise. This project will help to determine if prescribing hearing aids to patients without hearing loss is, in fact, beneficial and if so, why. It will also help to determine if some patients benefit more from hearing aids than others so that in the future, rehabilitation strategies can be better targeted toward individuals.

PI_NAMEs: PAPESH, MELISSA  (contact)

PROJECT_TERMS: active duty;Address;Adult;arm;Attention;Audiology;Auditory;auditory pathway;auditory processing;auditory rehabilitation;Auditory system;Auditory Threshold;behavior measurement;Behavioral;biopsychosocial;Caring;Characteristics;Clinic;Clinical;clinical care;clinical center;clinical decision-making;Clinical Management;Cognition;Cognitive;cognitive process;Communication;Communication difficulty;comorbidity;comparative;comparative efficacy;Counseling;Data;Decision Modeling;design;Devices;Diagnosis;Discipline;Ear;Education;Electrophysiology (science);Emotional;Equipment and supply inventories;evidence base;expectation;experience;Functional disorder;functional improvement;Future;Goals;Health;Hearing;Hearing Aids;hearing impairment;Hearing problem;Hearing Tests;help-seeking behavior;Heterogeneity;improved;Individual;individual patient;individualized medicine;interest;Intervention;Intervention Studies;Interview;Learning;Left;Liquid substance;Measures;Mediator;Medical;Memory;Mental Health;microphone;military service;Modality;Modernization;Nervous System;neural;Neuronal Plasticity;Noise;normal hearing;Outcome;Outcome Measure;Participant;patient oriented;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Performance;Peripheral;Physiological;Population;post intervention;Prevalence Study;primary outcome;processing speed;psychologic;psychosocial;Randomized;Randomized, Controlled Trials;Recommendation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Resources;response;Risk;Risk Factors;Sampling;satisfaction;secondary outcome;service member;Severities;sound;Source;Speech;standard of care;Stream;Subgroup;Technology;Testing;treatment arm;Treatment outcome;treatment planning;treatment response;treatment strategy;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: Evaluating Device-based Rehabilitation for Veterans with Functional Hearing Difficulties: A Randomized Controlled Trial

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Infectious Diseases;Kidney Disease;Precision Medicine;Sepsis

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Sepsis is a lethal condition commonly complicated by kidney failure (AKI) yet, despite decades of investigation we lack reliable predictors and treatment. In the present study we will utilize mouse models of sepsis associated AKI (sAKI) to establish blood-based biomarkers correlated with critical stages in the pathogenesis of renal tissue injury which will be used to diagnose and stage human AKI blood samples. The immediate outcome of this work will be the development of a liquid biopsy to diagnose and stage human sAKI.

PI_NAMEs: JANOSEVIC, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Anti-viral Response;Basic Science;biobank;Biological Markers;biomarker identification;Biopsy;Blood;Blood specimen;blood-based biomarker;cecal ligation puncture;Cell Fraction;Cells;Chronic Kidney Failure;Cisplatin;Clinical;clinical biomarkers;Clinical Data;Clinical Trials;clinically relevant;cohort;Complex;Creatinine;Data;design;Development;Diagnosis;diagnostic tool;differential expression;Disease;Early Diagnosis;End stage renal failure;Endotoxins;Etiology;Evolution;Failure;Functional disorder;Future;Genes;Goals;Human;Immune;improved;Indiana;Inflammatory;Injections;Injury to Kidney;insight;Investigation;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Failure;LCN2 gene;liquid biopsy;Maps;Mentors;Messenger RNA;MicroRNAs;miRNA expression profiling;Modeling;Molecular;molecular marker;Molecular Profiling;mortality;mouse model;mRNA sequencing;Mus;nephrotoxicity;Organ;Organ failure;Outcome;Pathogenesis;Patients;Population;Positioning Attribute;precision medicine;Proteins;Publishing;Renal Tissue;Reperfusion Injury;response;Sampling;Sepsis;septic;Series;Site;skills;Solid;specific biomarkers;Staging;Stratification;Supportive care;Testing;Therapeutic;timeline;tissue injury;Tissues;trafficking;transcriptome;transcriptomics;Translating;translational scientist;Translations;Universities;Whole Blood;Work

PROJECT_TITLE: Transcriptomic Diagnosis and Staging of Sepsis-Associated Acute Kidney Injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]