NIH_SPENDING_CATS: Biotechnology;Hematology

PI_NAMEs: HICKS, KEVIN GEORGE (contact)

PROJECT_TERMS: Acceleration;Area;Bioinformatics;Biological;Biological Assay;Blood;Cells;Cellular biology;Chemical Structure;Chemicals;Communities;Computer software;Data;Dialysis procedure;Disease;disease model;Education and Outreach;Equilibrium;Erythrocytes;Event;Foundations;functional group;Goals;Health;Hematological Disease;Hematology;Hematopoiesis;Heme;Homeostasis;innovation;insight;interest;International;Iron;Libraries;Mass Spectrum Analysis;Mediating;member;Metabolic Pathway;Metabolism;Metabolite Interaction;metabolome;metabolomics;Methods;Modification;molecular hematology;Non-Malignant;novel;novel strategies;Output;Peptides;Post-Translational Protein Processing;Preparation;Process;Progress Reports;protein complex;protein function;protein metabolite;protein protein interaction;protein purification;Proteins;Proteome;Proteomics;Regulation;Research;Sampling;service member;Services;Signal Pathway;Signal Transduction;Structure;Surface;targeted treatment;Techniques;Technology;Therapeutic Intervention;Tissues;Universities;Utah

PROJECT_TITLE: Proteomics Core


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Head-and-neck cancer patients who undergo radiation therapy often develop a significant side effect of xerostomia, or severe dry mouth, due to a radiation-induced loss of the cells that make saliva. Our therapeutic goal is to recreate a functional salivary gland in the laboratory, using a patient's own cells, and return them to the salivary bed after radiation to restore salivation. Our proposal leverages two irradiated animal models to develop the methodology to achieve full biointegration of the replacement gland such that both blood flow and nervous system interactions are restored to stabilize the functional transplanted new salivary gland.

PI_NAMEs: FARACH-CARSON, MARY C (contact);LOMBAERT, ISABELLE M.A.

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Achievement;Acinus organ component;adult stem cell;Allografting;alpha-amylase;Amylases;Animal Model;aquaporin 5;Artificial Organs;Autologous Transplantation;Autonomic nervous system;Beds;Biology;biomarker validation;Biomedical Engineering;Blood flow;Cell Differentiation process;Cell Polarity;cell replacement therapy;Cell Survival;Cells;Chronic;clinical translation;Comparative Pathology;Data;design;Device Designs;Digestion;Duct (organ) structure;Enzymes;epithelial stem cell;Epithelium;Excision;facial transplantation;Family suidae;Feasibility Studies;first-in-human;Fostering;genetic manipulation;Gland;Goals;Growth;Head and Neck Cancer;head and neck cancer patient;Homologous Transplantation;Human;Hydrogels;immunosuppressed;Immunosuppression;Implant;improved;in vivo;Insulin-Dependent Diabetes Mellitus;islet;Laboratories;Legal patent;Liquid substance;Luciferases;Lupus;man;Measurement;Measures;Methodology;Michigan;Miniature Swine;Modeling;Morphogenesis;Myoepithelial;Nerve;nerve supply;Nervous System;new technology;Nude Rats;nutrition;Operative Surgical Procedures;Oral cavity;Oral health;Organ;Organoids;Patients;Peripheral Nerves;Phenotype;Population;porcine model;post-transplant;Pre-Clinical Model;Production;Proteins;Protocols documentation;Radiation;Radiation therapy;reparative capacity;replacement tissue;Research;Research Personnel;restoration;Retrieval;Saliva;saliva secretion;Salivary;salivary cell;Salivary Glands;Series;side effect;Site;Sjogren's Syndrome;Source;stem;stem cell therapy;stem cells;Structure;Study models;success;System;Techniques;Testing;Therapeutic;Time;Tissue constructs;Tissue Engineering;Tissue Transplantation;Tissues;Translations;Transplantation;Water;Work;Xenograft Model;Xerostomia

PROJECT_TITLE: Functional Biointegration of Bioengineered Salivary Tissues in Irradiated Animal Models

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Lung;Lymphatic Research;Primary Immunodeficiencies;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE Autoimmune and autoinflammatory diseases afflict 7-9% of the world population, and the goal of this project is to understand how the cytosolic cGAS/STING DNA sensing pathways contributes to these potentially devastating diseases so that we can better control them. This project draws on investigators with complementary expertise and will apply exciting new tools and strategies to study how innate immune responses in non- hematopoietic cells can promote lung complications. Insights resulting from this project should give us an opportunity to develop better treatment strategies for the many patients who suffer from interstitial lung disease.

PI_NAMEs: FITZGERALD, KATHERINE A.;MARSHAK-ROTHSTEIN, ANN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immunity;Address;Adhesions;Alleles;Area;Autoimmune;Autoimmune Diseases;autoinflammation;autoinflammatory;autoinflammatory diseases;Automobile Driving;Bone Marrow Stem Cell;Bronchus-Associated Lymphoid Tissue;Cell Death;Cell Line;Cell Separation;cell type;Cells;cellular transduction;Chimera organism;cytokine;Cytosol;Data;design;Development;Disease;DNA;effective therapy;Embryo;Endothelial Cells;Endothelium;Exclusion;Exhibits;Fibrosis;fibrotic lung disease;Follow-Up Studies;functional outcomes;gain of function mutation;Gene Expression;gene function;Genes;Genetic Transcription;Goals;Hematopoietic;Heterozygote;Host Defense;human disease;Immune;In Vitro;in vivo evaluation;Individual;infancy;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;Interferons;Interstitial Lung Diseases;IRF3 gene;Knock-in;Lesion;Link;Lung;Lung Diseases;lymph nodes;Lymphatic Endothelial Cells;Lymphocyte;Lymphopenia;microbial;Molecular;Monitor;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Natural Immunity;neutrophil;novel;Omenn syndrome;Pathogenicity;Pathology;Pathway interactions;Patients;Peripheral;Phenotype;Play;Population;promoter;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Radiation Chimera;radioresistant;Rag1 Mouse;reconstitution;recruit;Reporter;Research;Research Personnel;Resistance;Respiratory Failure;Rheumatoid Arthritis;Role;Series;severe COVID-19;single-cell RNA sequencing;skin lesion;stem cells;Stimulator of Interferon Genes;STING agonists;STING-associated vasculopathy;Stromal Cells;Systemic Scleroderma;T-Lymphocyte;Tamoxifen;TBK1 gene;therapeutic target;Tissues;tool;transcriptome;treatment strategy;Vascular Endothelial Cell

PROJECT_TITLE: Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: WARD, DIANE MCVEY (contact)

PROJECT_TERMS: Area;Career Mobility;Collaborations;collaborative environment;Communities;Core Facility;Data;Data Analyses;design;Development;Disease;Education;Educational workshop;Electronic Mail;Emerging Technologies;Exposure to;Facebook;Feedback;Fostering;Funding;Goals;Hematology;Heme;Homeostasis;improved;Instagram;interest;Investigation;Iron;iron metabolism;Learning;Link;medical schools;Metals;Methodology;Modeling;Non-Malignant;Online Systems;outreach;outreach program;Postdoctoral Fellow;programs;Progress Reports;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Series;social media;Students;success;symposium;Technology;Training;Training Programs;Twitter;Universities;Utah;Vertebral column;virtual;virtual education;visiting scholar;web site;web-based tool

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Dissemination and Implementation Research;Heart Disease

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Public Health Relevance The Tulane University training program for Diversity in tRanslation and Implementation research in cardioVascular disEase (DRIVE) will draw on the expertise of outstanding investigators to provide trainees from underrepresented backgrounds with the didactics, experience, skills, mentoring and resources they need to become successful researchers in CV translation and implementation sciences. The proposed training program seeks to contribute to diversifying the translation and implementation workforce, reducing the burden of CV diseases and metabolic risk factors, eliminating health disparities, and improving health equity in Louisiana and the nation.

PI_NAMEs: BAZZANO, LYDIA  (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Cardiovascular Diseases;implementation research;Training Programs;Translational Research;Universities

PROJECT_TITLE: Tulane University Training Program for Diversity in tRanslation and Implementation research in cardioVascular disEase (DRIVE)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Depression;Disability Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Primary Health Care;Rehabilitation;Serious Mental Illness;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chronic pain and depression are prevalent in MCI and early stage AD, and increase the risk of incident dementia. Most of MCI and AD patients with chronic pain and depression are treated in primary care. The proposed primary care study will evaluate the impact of 8 in-person sessions and 12 phone sessions of PATH- Pain compared with an Attention Control Usual Care group and will assess cognitive, affective, and functional outcomes in 100 older adults with MCI or early stage probable or possible AD and comorbid chronic pain and depression.

PI_NAMEs: KIOSSES, DIMITRIS N (contact);RAVDIN, LISA D;REID, MANNEY CARRINGTON

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Address;Affective;Aftercare;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;attentional control;Behavioral;Calendar;Caregivers;Certification;chronic depression;chronic pain;chronic pain patient;Clinical;clinically significant;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;comorbid depression;comorbidity;Data;Dementia;dementia risk;depressive symptoms;distraction;emotion dysregulation;emotion regulation;Emotional;Emotions;environmental adaptation;experience;Family member;Feeling hopeless;follow-up;Friends;functional outcomes;Habits;Health;Impaired cognition;improved;Individual;innovation;Internal Medicine;Intervention;Interview;Location;Measures;Mediating;Medicine;member;Mental Depression;Mental Health;mild cognitive impairment;Montgomery and Asberg depression rating scale;Neurology;Neuropsychology;novel;older adult;Outcome;Pain;Pain intensity;Pain management;pain outcome;pain reduction;pain-related disability;Pamphlets;Participant;Patients;perceived stress;Persons;Pharmaceutical Preparations;Population;positive emotional state;power analysis;Primary Care;primary outcome;Probability;Problem Solving;Procedures;Psychiatry;psychosocial;Public Health;Questionnaires;Randomized;Reaction;Recommendation;recruit;Research Assistant;Research Personnel;Resources;Risk;satisfaction;secondary outcome;Severities;sex;Site;Stress;stress reduction;Structure;sustained attention;Tablets;Techniques;Telephone;telephone session;Testing;therapy design;Time;tool;treatment as usual;treatment effect;usual care arm

PROJECT_TITLE: PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults with MCI and Early Stage AD


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative This application is for support of three training positions in an established program in digestive diseases that has been funded since 1975 at the Division of Gastroenterology, University of California, San Francisco. The Program's goal is preparing trainees for careers in academic luminal gastroenterology, and its track record in this regard is outstanding, with numerous graduates of the program now in leadership positions. These talented individuals are well poised to capitalize on the exciting state of GI related research, with its transformative and translational potential.

PI_NAMEs: MA, AVERIL I (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Grant;Training

PROJECT_TITLE: INRSA Training Grant in Gastroenterology


ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative Autoimmune diseases if uncontrolled can cause severe tissue damage and even death. We have recently discovered BDL, which is a novel B cell subset that attenuates the severity of inflammatory diseases by induction of CD4+Foxp3+ regulatory T cell proliferation. This application outlines a strategy to develop a universal first-of-its kind B cell-derived adoptive cell therapy for the treatment of autoimmunity.

PI_NAMEs: DITTEL, BONNIE N (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: adaptive immune response;Adoptive Cell Transfers;Affect;American;anti-CD20;Attenuated;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;B Cell Proliferation;B-Lymphocyte Subsets;B-Lymphocytes;Biology;BLR1 gene;Cell Count;cell killing;Cell Proliferation;Cell Therapy;Cessation of life;Characteristics;chemokine;chemokine receptor;chimeric antigen receptor;Clinical Trials;cost;cost effective;cost estimate;CRISPR/Cas technology;CXCL13 gene;design;Development;Disease;Dose;Engraftment;Enterobacteria phage P1 Cre recombinase;Face;FOXP3 gene;Genes;Genetic Engineering;Glucocorticoids;Goals;Haplotypes;HLA G antigen;Homeostasis;Human;Human Herpesvirus 4;Image;Immune;Immune response;Immune system;Immune Tolerance;Immunoglobulin D;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;inhibitor;innovation;insight;Ligands;LoxP-flanked allele;Lymphocyte;Mature B-Lymphocyte;Measures;Mediating;MHC Class I Genes;migration;MS4A1 gene;Mus;Names;Natural Killer Cells;novel;Organ;overexpression;Pathogenicity;Patients;Phenotype;Play;Population;Predisposition;Proliferating;receptor;Regulatory T-Lymphocyte;Role;Safety;Severities;side effect;Specificity;Spleen;Steroids;suicide gene;T-Cell Proliferation;T-Lymphocyte;Therapeutic;therapeutic target;Tissues;Treatment Cost;Tumor Necrosis Factor Receptor;virtual

PROJECT_TITLE: Development of a B Cell Therapeutic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Mobile element insertions (MEIs) represent a largely undefined component of the genetic architecture of neurological disorders, as a number of MEIs have been associated with alternative splicing in these disorders but large-scale genome-wide functional characterization has not been systematically performed across tissues. This program study will functionally characterize the impact of MEIs on alternative splicing from whole-genome sequencing and transcriptome sequencing in large cohorts using new developments in deep learning models. These results will enhance our understanding of the etiological role and pathogenic mechanisms associated with MEIs in neuronal development and human neurological disorders.

PI_NAMEs: GAO, DADI  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Algorithms;Alternative Splicing;Alzheimer's Disease;Applied Skills;Autopsy;Basic Science;Biology;Blood;Brain;brain control;Brain Diseases;brain tissue;career development;Cells;Chromosome Pairing;cohort;Cohort Studies;collaborative environment;Computational Biology;Computer Analysis;Computer Models;convolutional neural network;CRISPR/Cas technology;Data;Data Set;Dedications;deep learning;deep learning model;Defect;Detection;Development;Disease;disease model;DNA;DNA Insertion Elements;Dorsal;drug development;Elements;Etiology;Event;Evolution;Excision Repair;Familial Dysautonomia;Feedback;Fellowship;Filipino;functional genomics;functional outcomes;gene function;General Hospitals;Generations;Genes;Genetic;genetic architecture;Genetic Transcription;Genome;genome analysis;genome editing;genome sequencing;genome-wide;Genomics;Genotype-Tissue Expression Project;Haplotypes;Human;human disease;Human Genome;in silico;Individual;insight;International;Introns;Laboratories;Lateral;Learning;Linear Regressions;Machine Learning;Maps;Massachusetts;Measures;medical schools;Mentors;Mentorship;Methods;Michigan;Mind;Minisatellite Repeats;Modeling;Molecular;mosaic;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurological Models;Neuromuscular Diseases;neuron development;Neurons;novel;Outcome;Pathogenicity;Pattern;Peripheral;Pharmaceutical Preparations;Phase;Population;Prefrontal Cortex;Process;programs;Property;Regulation;Research;Research Personnel;response;Retroelements;RNA Splicing;Role;Sampling;Schizophrenia;Science;Shapes;skills;Source;Specificity;statistical learning;TAF1 gene;Techniques;therapeutic target;Therapeutic Trials;Tissue-Specific Splicing;Tissues;Training;Training Programs;Transcription Alteration;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Universities;Untranslated RNA;Variant;whole genome;Work;X-linked dystonia parkinsonism

PROJECT_TITLE: Deep Learning Approaches to Decipher the Impact of Mobile Element Insertion on Alternative Splicing in Neurological Disorders

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: RELEVANCE: CCHMC provides an exceptional environment in which to study the molecular mechanisms of various aspects of hematopoiesis and to pursue innovative basic and translational research and therapies for a wide variety of non-malignant blood diseases. The Cincinnati Cooperative Center of Excellence in Hematology (CCCEH) will provide an essential organizational platform that allows coordination in basic and translational hematology research areas and will facilitate NIH funded and new studies by established and new investigators of experimental hematology around US.

PI_NAMEs: STARCZYNOWSKI, DANIEL ;ZHENG, YI  (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Affect;Area;base;Basic Science;Behavior;Biological Process;Biology;Blood Cells;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;career;cell behavior;Cell Therapy;Cells;Cellular biology;Clinical;Clinical and Translational Science Awards;clinical care;Clinical Research;Clinical Trials;collaborative approach;collaborative environment;college;Communities;Coupled;data exchange;Disease;drug discovery;Dysmyelopoietic Syndromes;Education;educational atmosphere;Environment;Erythrocytes;Erythroid;Experimental Hematology;Faculty;Fostering;Funding;Future;Gene Delivery;Gene Expression;gene therapy;Genes;Genetic;genome editing;Genomics;Goals;Grant;Growth;Hematological Disease;Hematologist;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Home;Image;immunohematology;Immunology;In Vitro;in vivo;Infrastructure;Inherited;innovation;Institution;interdisciplinary approach;International;Lentivirus;Link;Lymphoid;Medical center;Medicine;member;Mentors;Methods;Molecular;Molecular Biology;molecular hematology;Mouse Strains;Mus;Myelogenous;nature center;Non-Malignant;Office of Administrative Management;outreach;Pediatric Hospitals;pre-clinical;pre-clinical research;Production;programs;Publications;Recording of previous events;recruit;Research;Research Activity;Research Personnel;Retroviridae;Scientist;screening;Services;Sickle Cell Anemia;Signal Transduction;Site;small hairpin RNA;social media;Sorting;stem cell biology;Structure;Students;symposium;Technology;technology development;Training;Transgenic Organisms;translational applications;Translational Research;translational study;Transplantation;United States National Institutes of Health;Universities;vector;Viral;Viral Vector;Virus;Xenograft procedure


PI_NAMEs: ZHENG, YI  (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Animals;Area;Attention;Biometry;Budgets;Businesses;career;Clinical;Clinical Trials;Communication;Communities;Data Analyses;Ensure;Experimental Hematology;Faculty;Fertilization;Fostering;Goals;Grant;Growth;Hematological Disease;Hematology;Human Resources;human subject;Immunology;Information Technology;Infrastructure;Institution;Interdisciplinary Study;interest;Internet;Investigation;Journals;Leadership;Malignant Neoplasms;Medical center;meetings;member;Mentors;Methodology;Modeling;Molecular;molecular hematology;Non-Malignant;novel;operation;outreach;Patients;Pediatric Hospitals;Preparation;programs;Protocol Compliance;protocol development;Reporting;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Sampling;scientific organization;Scientist;Services;Site;social media;statistical service;Structure;success;Supervision;synergism;Technology;Therapeutic;Training;Training Activity;Translational Research;Translations;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Prevention

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE This project examines how environmental chemicals interact to cause craniofacial birth defects that cannot be explained by the individual action of currently recognized environmental or genetic factors. The goal of this research is to characterize avoidable risk factors in the environment and evaluate their combined contribution to congenital malformations in order to inform risk mitigation strategies.

PI_NAMEs: BEAMES, TYLER GEORGE (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;Affect;Animal Model;antagonist;Attention;Biological;Biological Assay;Brain;career;Cell Culture System;Chemicals;Communication;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;Creativeness;critical period;cyclopamine;Data;design;Development;Developmental Biology;developmental toxicity;developmental toxicology;Disease;Dose;Embryo;Embryonic Development;Environment;environmental chemical;Environmental Risk Factor;Etiology;experience;Experimental Designs;Exposure to;Face;frontier;Genetic;Goals;Government Agencies;Holoprosencephaly;Human;Human Characteristics;In Vitro;in vitro Assay;in vivo Model;Individual;inhibitor;Investigation;Link;malformation;Mediating;Molecular;Molecular Target;Morphogenesis;mouse model;Mus;National Institute of Environmental Health Sciences;Newborn Infant;novel;orofacial cleft;Outcome;Pathogenesis;Pathway interactions;Play;Post-Translational Protein Processing;Predisposition;Prevention;Prevention strategy;Process;Prosencephalon;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;risk mitigation;Role;SHH gene;Signal Transduction;smoothened signaling pathway;Sonic Hedgehog Pathway;System;Testing;Toxic effect;Toxicology;Training;transcription factor;United States;Work;Xenobiotics

PROJECT_TITLE: Multifactorial environmental inhibition of Sonic hedgehog signaling: Impact of chemical interactions on pathway activity and craniofacial development


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

PI_NAMEs: STARCZYNOWSKI, DANIEL  (contact)

PROJECT_TERMS: Acceleration;Animal Model;Animals;Biological Assay;blastocyst;career;cell behavior;Cell Lineage;Cell Physiology;Cell Transplantation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;cost effective;cost effectiveness;Cost efficiency;cost efficient;cytokine;design;Development;Disease;drug development;Drug Monitoring;Effectiveness;Engineering;Engraftment;epigenetic profiling;Future;gang;Gene Modified;Gene Targeting;Gene Transfer;Generations;Genetic;genome editing;Genome engineering;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hematological Disease;Hematology;Hematopoietic;Hematopoietic stem cells;Human;Human Resources;IL3 Gene;Immunocompromised Host;Immunodeficient Mouse;implantation;improved;in vivo;in vivo evaluation;Injections;innovation;Investigation;irradiation;Laboratories;member;Modality;Modeling;Molecular;Molecular Analysis;molecular hematology;Monitor;mouse model;Mouse Strains;Mus;Myelogenous;Newborn Infant;Non-Malignant;Non-Neoplastic Hematologic and Lymphocytic Disorder;novel;novel therapeutics;pharmacologic;Phase;Population;pre-clinical;preclinical study;Procedures;Productivity;PTPRC gene;Publications;Pump;Regulation;Research;Research Design;Research Personnel;Resources;Scientist;Security;Services;Standardization;stem cell engraftment;stem cell therapy;success;Supervision;T-Lymphocyte;Technology;Therapeutic;Tissue Banks;Training;transcriptomic profiling;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Transplantation;Vendor;Xenograft procedure

PROJECT_TITLE: Xenotransplant and Genome Editing Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: GENETICS

PI_NAMEs: CHOW, CLEMENT  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: biological adaptation to stress;Disease;endoplasmic reticulum stress;Genetic Variation;protein folding

PROJECT_TITLE: Investigating the impact of genetic variation on the ER stress response, protein folding, and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PI_NAMEs: FILIPPI, MARIE-DOMINIQUE  (contact)

PROJECT_TERMS: analysis pipeline;Area;ATAC-seq;Awareness;Bioinformatics;Biological;Biological Assay;Biological Process;biological systems;Biology;Bone Marrow;Cell Count;Cell Differentiation process;Cell Physiology;cell preparation;Cell Separation;Cells;Cellular biology;cellular imaging;Cities;Classification;Client;Complex;Consultations;Core Facility;cost;Data Analyses;data analysis pipeline;Data Analytics;data integration;Data Set;Dedications;design;Development;dimensional analysis;Dimensions;Disease;Dissection;Ensure;Epigenetic Process;epigenome;Equipment;Erythroid Cells;experience;Experimental Designs;Flow Cytometry;Fostering;Genomics;Goals;Health Services Accessibility;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;Image;imaging facilities;Imaging Techniques;Immune;Immunofluorescence Immunologic;Immunology;Immunophenotyping;implementation barriers;In Situ;Individual;innovation;Institution;instrument;intercellular communication;Joints;large datasets;Lysosomes;Measures;microscopic imaging;Mitochondria;Molecular;Myeloid Progenitor Cells;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;novel;novel strategies;Organelles;Population;Population Heterogeneity;Procedures;Process;progenitor;programs;Proteome;Protocols documentation;Research;Research Design;Research Personnel;Research Project Grants;Resolution;Services;Signal Transduction;single cell analysis;single-cell RNA sequencing;Standardization;stem;stem cell biology;stem cells;superresolution microscopy;Systems Biology;Techniques;Technology;Tissues;tool;Training;Training and Education;transcription factor;transcriptome;transcriptomics;Translations;ultra high resolution;Universities;Wisconsin;Work

PROJECT_TITLE: Single Cell Characterization and Procurement Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Cardiac imaging with PET/CT has the unique ability to accurately quantify absolute myocardial blood flow and allows robust detection of coronary artery disease and patient risk stratification; however, it requires a high level of on-site technical expertise to maximize its broad capabilities. The investigators propose to develop novel artificial intelligence algorithms for simplified and automated cardiac PET/CT processing and integration of the information derived from these scans. This work will result in practical clinical tools for physicians—increasing the accuracy of patient assessment beyond what is possible by the current practice of subjective visual analysis of images and mental integration of multimodal data.

PI_NAMEs: DI CARLI, MARCELO F;SLOMKA, PIOTR J (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Adoption;adverse outcome;Anatomy;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;artificial intelligence model;Atherosclerosis;attenuation;Automation;biomedical imaging;Blood flow;Cardiac;Cardiometabolic Disease;cardiovascular imaging;Cause of Death;Chest;Clinical;clinical application;Clinical Data;clinical imaging;Collaborations;Complex;Computer software;Computing Methodologies;Coronary;Coronary Arteriosclerosis;coronary artery calcium;Data;deep learning;Detection;Development;Diabetes Mellitus;Diagnostic;diagnostic accuracy;Diffuse;disability;Disease;disease diagnosis;disorder risk;diverse data;Dose;Engineering;experience;explainable artificial intelligence;Fatty acid glycerol esters;Goals;Growth;heart imaging;Hybrids;Image;Image Analysis;image processing;imaging biomarker;imaging modality;imaging Segmentation;improved;Institution;Intelligence;Ischemia;Joints;Kinetics;Knowledge;Measurement;Measures;medical specialties;Methods;Microvascular Dysfunction;Modality;multidisciplinary;multimodal data;multimodality;Myocardial;Myocardial perfusion;Nature;new technology;novel;Obesity Epidemic;outcome prediction;Patient Care;Patient risk;Patients;Performance;Perfusion;perfusion imaging;Physicians;Positron-Emission Tomography;prognostic;Protocols documentation;prototype;Psyche structure;Quality Control;Radioisotopes;Radiology Specialty;Research;Research Personnel;Risk Assessment;risk stratification;Scanning;single photon emission computed tomography;Site;Statistical Models;supervised learning;Survival Analysis;Technical Expertise;Techniques;Technology;Testing;tool;Translating;unsupervised learning;Visual;Widespread Disease;Work

PROJECT_TITLE: Integrating Artificial Intelligence for Optimal Analysis of CardiacPET/CT

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


PI_NAMEs: CANCELAS, JOSE A. (contact)

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Adenovirus Vector;Basic Science;bench to bedside;Biological;Biological Assay;Biological Phenomena;biological research;Biology;Cells;Cellular biology;Clinic;Clinical;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Consultations;Core Facility;cost;CRISPR library;CRISPR/Cas technology;Cyclic GMP;delivery vehicle;design;Development;Developmental Therapeutics Program;Disease;DNA;DNA Viruses;early phase clinical trial;Ensure;Evaluation;experience;Feasibility Studies;Functional disorder;Funding Agency;Future;Gammaretrovirus;Gene Delivery;Gene Expression;Gene Modified;gene therapy;Gene Transfer;Genes;genetic manipulation;Genetic study;genetically modified cells;Goals;Guide RNA;Hematological Disease;Hematology;high throughput screening;Human;Human Genome;Human Resources;Individual;industry partner;Infrastructure;innovation;Institution;interest;Investigation;Investigational Drugs;knock-down;Knock-out;knockout gene;Laboratories;Laboratory Research;Lentivirus;Lentivirus Vector;Libraries;manufacture;Materials Testing;Medical center;Methodology;Molecular;Monitor;mouse genome;Mus;new technology;novel;Pediatric Hospitals;Phase;pre-clinical;preclinical study;Preparation;Procedures;Process;Production;Quality Control;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Resources;RNA;Robotics;scale up;screening;Serotyping;Services;small hairpin RNA;small molecule;Source;Spumavirus;System;Technology;Testing;therapeutic development;therapeutic gene;Time;tool;Training;Translating;translational barrier;translational pipeline;Translational Research;Translations;Ultracentrifugation;vector;Viral Vector

PROJECT_TITLE: Gene Delivery Core


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Multiple tobacco product (MTP) use—or the concurrent use of two or more tobacco products—is the dominant pattern of tobacco use among youth in the United States, however, little research has been conducted on communication messages that could prevent and reduce youth MTP use. Using rigorous and innovate methods, the overarching goal of the proposed research is to develop and evaluate messages about the harms of MTP use. This research would make significant and timely contributions to the development of tobacco control communication strategies in the United States and is responsive to FDA’s interest in communications research.

PI_NAMEs: KOWITT, SARAH  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adult;Affective;Age;Applications Grants;apprenticeship;arm;Award;behavioral outcome;cardiovascular risk factor;career;Cigar;Cigarette;Cognitive;Communication;Communication Research;communication theory;Cues;design;Development;Educational workshop;Effectiveness;effectiveness testing;eHealth;Electronic cigarette;Elements;Emotions;Experimental Designs;experimental study;Focus Groups;Goals;hands on research;health communication;high risk;Image;innovation;interest;Intervention;K-Series Research Career Programs;Lead;low socioeconomic status;Mental Health;Mentorship;Methods;Myocardial Infarction;Nicotine;Nicotine Dependence;Pattern;Performance;Prevalence;prevent;preventable death;Randomized;Randomized, Controlled Trials;Reaction;reduce symptoms;Research;Research Activity;Respiratory Disease;Risk;Risk Factors;Sampling;Self Efficacy;Smoker;Socioeconomic Status;Stroke;substance use;Symptoms;Testing;Text Messaging;theories;Time;Tobacco;tobacco control;Tobacco Dependence;tobacco products;Tobacco use;tobacco user;Training;United States;Work;Youth

PROJECT_TITLE: Communication Messages to Reduce Youth Multiple Tobacco Product Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because many of mycobacterial factors that are modified by N terminal acetylation promote survival of mycobacteria within the host during infection and are potential targets for vaccine and therapeutic development, which would help alleviate the TB epidemic. This research is relevant to NIH’s mission because understanding the mechanisms promoting and regulating the modification of mycobacterial proteins will contribute fundamental knowledge, the application of which may positively impact the prevention, diagnosis and treatment of TB.

PI_NAMEs: CHAMPION, PATRICIA A (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acetylation;Acetyltransferase;Affect;Amino Acids;amino group;Animals;Antibiotic Resistance;Antibiotics;Area;Bacteria;Bacterial Infections;Bacterial Proteins;Bacteriology;Binding;Biochemical;Biological Assay;Carbon;Charge;Chemistry;Cholesterol;Chronic;chronic infection;Data;Diagnosis;Disease;ELF3 gene;Enzymes;Epidemic;Event;Foundations;Funding;Future;Genetic;genetic manipulation;Genus Mycobacterium;Growth;Half-Life;Human;human pathogen;In Vitro;Individual;Infection;innovation;Knowledge;Label;Ligation;Link;Lipids;Lysine;Macrophage;Malignant Neoplasms;Metabolism;Methods;Mission;Modeling;Modification;Molecular;mycobacterial;Mycobacterium marinum;Mycobacterium tuberculosis;N-terminal;Neurodegenerative Disorders;new therapeutic target;Organism;Parasitic infection;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Phase;Phenotype;Post-Translational Protein Processing;Prevention;Process;Productivity;Protein Acetylation;protein function;Proteins;Proteomics;Protocols documentation;Public Health;Publishing;Regulation;Research;small molecule;Source;Substrate Specificity;System;Testing;therapeutic development;therapeutic target;tool;Transfer RNA;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;vaccine development;Virulence;Virulence Factors

PROJECT_TITLE: Mechanisms and Consequences of Mycobacterial N-terminal Protein Acetylation

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


PI_NAMEs: WARE, RUSSELL E (contact)

PROJECT_TERMS: Awareness;Basic Science;Biology;Blood;bone marrow failure syndrome;career;career development;Child;Clinical;Collaborations;Communication;Communities;Creativeness;Data;Development;Doctor of Philosophy;education resources;Educational workshop;Environment;Erythropoiesis;Experimental Hematology;Feedback;Floor;Fostering;Funding;Future;Goals;graduate student;Grant;Health;Hematology;Hematopoiesis;High School Student;immunohematology;Institution;Interdisciplinary Study;International;Internet;Internships;Journals;Laboratories;lectures;Letters;meetings;member;Mentors;Midwestern United States;Mind;Mission;Myelogenous;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Malignant;novel;Pediatric Hospitals;Persons;Postdoctoral Fellow;Principal Investigator;Productivity;professor;programs;recruit;Reproducibility;Research;Research Personnel;Resources;Rotation;sabbatical;Science;Scientist;Secure;Series;Sickle Cell Anemia;Signal Transduction;stem cells;summer internship;symposium;Techniques;Training;Training Programs;Translational Research;Travel;undergraduate student;virtual;Visit;Work

PROJECT_TITLE: Enrichment


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health The relevance of in this training program to the health of Americans encompasses the need to train the next generation of biomedical scientists, and to address a critical shortage of surgeon-scientists. This training includes i) the application of “cutting edge” strategies to musculoskeletal regenerative medicine and ii) the multidisciplinary, team approach required to use those strategies from the laboratory to the bedside.

PI_NAMEs: ADAMS, JOHN S (contact);BERNTHAL, NICHOLAS M.;LYONS, KAREN M.

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Regenerative Musculoskeletal Medicine Training Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE The Frontiers in Science (FIS) Conference promotes research and networking opportunities for pediatric trainees interested in investigative careers by facilitating interactions between pediatric residents, pediatric researchers, and department chairs. Now in its 31st year, FIS synergizes with the NICHD-funded Pediatric Scientist Development Program focusing on pediatric residents-in-training and encouraging careers in academic pediatrics as future physician scientists. Our renewal request is to support a portion of the infrastructure toward organizing and conducting the conference, and a portion of the conference expenses to provide partial support for ~75 pediatric residents-in-training to attend the FIS conference with special emphasis on increasing the recruitment of women and individuals of all types of diversity (URiM).

PI_NAMEs: CLAPP, DAVID W (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Area;Award;Basic Science;Biomedical Research;career;career development;Child Care;Childhood;clinical care;Clinical Trials;clinically relevant;Counseling;Data;demographics;Department chair;Development;Disease;Distress;Educational workshop;Enrollment;Ensure;experience;Feedback;Fellowship;Fellowship Program;frontier;Funding;Future;Gender;Geography;Goals;Growth;Health;Health Policy;Health Status;improved;Individual;Infrastructure;innovation;Institution;interest;International;Knowledge;Leadership;lecturer;Life;Link;Measures;medical schools;medical specialties;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mind;Modeling;National Institute of Child Health and Human Development;next generation;Patient Care;patient oriented;Patients;pediatric department;pediatrician;pediatrician scientist;Pediatrics;peer;Perception;Physician's Role;Physicians;Play;Positioning Attribute;Process;Program Accessibility;Program Development;programs;Published Comment;recruit;Research;Research Personnel;Research Support;Research Training;Residencies;Role;role model;Scholars Program;Scholarship;Science;Scientist;Students;success;Surveys;symposium;synergism;Time;Training;Training Programs;Translating;Translational Research;trend;United States;United States National Institutes of Health;Woman;workforce needs

PROJECT_TITLE: FRONTIERS IN SCIENCE CONFERENCE

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE The present P30 application will provide research support for NEI R01-funded investigators and serve as a catalyst for the major expansion of vision research currently under way at the University of California Irvine (UCI). Our objective is to establish three research cores plus an administrative group that will advance the research programs of individual investigators by providing state-of-the-art facilities together with outstanding technical support by the Core Managers. The research cores are: 1. Ocular microanatomy, 2. Visual function and non-invasive ocular imaging, and 3. Ocular mass spectrometry, lipidomics, and proteomics.

PI_NAMEs: KEFALOV, VLADIMIR JIVKOV (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Area;California;career;catalyst;Cell Culture Techniques;Center Core Grants;Collaborations;Communities;Core Facility;cost effectiveness;Data;Educational process of instructing;empowerment;Ensure;Equipment;Faculty Recruitment;Funding;Future;Health Services Accessibility;Human Resources;Image;improved;Individual;Infrastructure;Institution;instrument;instrumentation;Laboratories;lipidomics;Maintenance;Mass Spectrum Analysis;medical schools;Methods;Microanatomy;mid-career faculty;new technology;ocular imaging;Ophthalmology;Postdoctoral Fellow;prevent;Productivity;programs;Proteomics;recruit;Research;research facility;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Sampling;Scientist;Services;Stains;Structure;Students;Technical Expertise;Techniques;Testing;Time;tool;Training;Universities;Use of New Techniques;Vision;Vision research;Voting;Work

PROJECT_TITLE: NEI UCI Center Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: Project Narrative Not require per FOA.

PROJECT_TERMS: Center Core Grants;Communities;Funding;Goals;Information Services;Joints;Occupational activity of managing finances;Policy Developments;Research;Research Activity;Research Support;Resource Development;Resources;Strategic Planning;Structure;Vision;Vision research

PROJECT_TITLE: Administrative core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: JESTER, JAMES V (contact)

PROJECT_TERMS: automated image analysis;Center Core Grants;Computer software;Doctor of Philosophy;Fluorescence;Funding;Goals;histological stains;Image Analysis;image processing;instrumentation;investigator training;Light;light microscopy;Microanatomy;Microscope;Microscopic;multi-photon;quantitative imaging;repaired;Research Personnel;System;Techniques;Tissues;Vision research;vision science

PROJECT_TITLE: Core 1. Ocular Microanatomy Core (OMC)


PROJECT_TERMS: Anterior;Center Core Grants;Data Analyses;Doctor of Philosophy;Equipment;Eye;Goals;in vivo;instrumentation;laboratory experience;Laboratory Personnel;Measures;Mus;ocular imaging;Protocols documentation;repaired;Research Personnel;Structure;Techniques;Tissues;two photon microscopy;Vision;Vision research

PROJECT_TITLE: Core 2. Visual Function and Non-invasive Ocular Imaging Core (VFNOIC)


PI_NAMEs: MARTIN, RACHEL WAGNER (contact)

PROJECT_TERMS: Biological;Center Core Grants;Complex;cost effective;Data;Data Analyses;Disease;Doctor of Philosophy;drug distribution;Equipment;experimental analysis;experimental study;Goals;instrumentation;laboratory experience;Laboratory Personnel;lipidomics;Lipids;Mass Spectrum Analysis;Measures;Modality;Modification;Molecular;Proteins;Proteomics;Research Personnel;Research Project Grants;Sampling;Secure;small molecule;Techniques;Tissues;Vision;Vision research;Visual System

PROJECT_TITLE: Core 3. Ocular Mass Spectrometry, Lipidomics, and Proteomics Core (OMSLPC)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative This program will encourage and prepare neurology and neurosurgery residents, particularly those from groups historically under-represented in academic medicine, to enter careers in neuroscience. The program's trainees will receive outstanding training and mentoring in research so that they are well positioned to compete for individual career research funding. Their discoveries on the fundamental bases and treatments for disorders of the nervous system will diminish the personal and societal burden of neurologic disease.

PI_NAMEs: HARSH, GRIFFITH R. (contact);ROGAWSKI, MICHAEL A.

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Ally;base;Basic Science;Biological Sciences;Brain;career;Center for Translational Science Activities;Clinical;Clinical Research;Clinical Sciences;clinical translation;college;Communities;Complement;Data Collection;design;Development;Doctor of Philosophy;Education;Education Projects;education research;education resources;Educational Activities;Educational Curriculum;Engineering;Environment;Ethics;Exercise;experience;Experimental Designs;Faculty;faculty mentor;Fellowship;Fostering;Funding;Future;gender diversity;Goals;Grant;Health;Health system;health training;Human Resources;improved;Incubators;Individual;innovation;Institution;interest;Investigation;Joints;K-Series Research Career Programs;Laboratories;Leadership;Learning;Location;Manuscripts;Medical;medical schools;Medicine;member;Mentors;Mentorship;Mind;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;Neurosciences;Neurosciences Research;neurosurgery;Neurosurgical Procedures;novel;Participant;Patient Care;Physicians;Positioning Attribute;Preparation;Primates;Production;Productivity;Program Development;programs;racial diversity;recruit;regenerative;Reporting;Research;Research Project Grants;Research Support;Research Training;Residencies;Resources;role model;Schools;Scientist;skills;socioeconomic diversity;Structure;success;Training;Training Programs;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: UC Davis Clinician Neuroscientist Development Program


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Women's Health Research

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Early internalizing problems represent a significant public health concern; yet, despite the prevalence of internalizing problems, factors underlying their early development are not well understood. Research examining developmental pathways leading to internalizing problems among school-age children (age 5) is vital for prevention and early intervention efforts aimed at addressing modifiable factors within the family (e.g., parental psychopathology and maladaptive parenting), which will improve mental health throughout the lifespan and reduce the economic burden on society. Thus, the proposed study will investigate pathways present in the early family environment – originating in pregnancy and unfolding during the first three years of life – that contribute to internalizing problems among school-age children.

PI_NAMEs: LAIFER, LAUREN M (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 5 year old;academic preparation;Address;Age;Anxiety;Appointment;associated symptom;Behavioral;career;Child;Child Rearing;Childhood;Climate;Clinical Psychology;Code;cohort;Communities;comorbid depression;comorbidity;Data;Data Collection;Development;Dimensions;Distress;early childhood;Early Intervention;Economic Burden;Educational process of instructing;Educational workshop;emotion regulation;Emotional;Emotions;Environment;experience;Face;Family;Family Study;Fathers;Feeling;Goals;Healthcare Systems;Home;improved;Individual;infancy;intergenerational;Intervention;Laboratories;Life;life span;Link;Longitudinal Studies;Measures;Mediating;Mental Depression;Mental Health;Mentorship;Methods;Modeling;Mothers;negative affect;Nursery Schools;Parent-Child Relations;parental influence;Parents;Pathway interactions;Patient Self-Report;Perinatal;Post-Traumatic Stress Disorders;Postpartum Period;Predisposition;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention;preventive intervention;Psychopathology;Public Health;Reaction;Research;Research Personnel;Research Training;response;Risk;Risk Factors;Role;Sampling;School-Age Population;Schools;screening;social;Socialization;socialization behavior;Societies;Statistical Data Interpretation;Supervision;Surveys;Symptoms;System;theories;Thinking;Time;Training;Training Programs;transmission process;Trauma;trauma exposure

PROJECT_TITLE: Parental trauma-related distress trajectories predict child internalizing symptoms through unique emotion-related socialization behaviors: An examination from pregnancy to school-age

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative: Despite the advances in understanding of its genomic and molecular basis, prostate cancer (PCa) continues to take one human life every 18 minutes in the USA alone, demanding an unmet need for a simple, and minimally invasive approach that will definitively diagnose PCa. Our preliminary results of a novel, uniplex, molecular, urine assay on 250 blinded samples of voided urine, demonstrated >98% sensitivity for PCa detection and 100% specificity to detect benign prostatic hyperplasia (BPH). The investigation, when successfully completed, will have a significant clinical and financial impact as it will develop a simple, affordable, patient-friendly, noninvasive assay that will save patients from over diagnosis, over treatment, minimize the number of unnecessary biopsies, reduce patient morbidity and save millions of healthcare dollars.

PI_NAMEs: THAKUR, MATHEW LAXMAN (contact);TRABULSI, EDOUARD JOHN

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: Advocate;Attention;Benign;Benign Prostatic Hypertrophy;Biochemistry;Biological Assay;Biological Markers;Biopsy;Blinded;Blood;Breast;cancer biomarkers;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Patient;Cell Separation;Cells;Cessation of life;Clinical;clinical practice;design;detection assay;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;Digital Rectal Examination;Disease;efficacy evaluation;FDA approved;Fingers;Fluorescence;fluorophore;Friends;Genomics;Goals;Healthcare;Histology;HOXC6 gene;Human;Image;in vivo;Indolent;innovation;Investigation;Label;Life;Literature;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Messenger RNA;Methods;minimally invasive;Molecular;Molecular Profiling;Morbidity - disease rate;Names;Non-Invasive Detection;noninvasive diagnosis;North America;novel;optical imaging;overexpression;overtreatment;Pathology;Patients;Peptides;Predictive Value;Printing;Procedures;Prostate;prostate biopsy;prostate cancer cell;Prostate-Specific Antigen;Proteins;receptor;Rectum;Research Personnel;Role;Sampling;Schedule;Screening for Prostate Cancer;Sensitivity and Specificity;Serology;Serum;serum PSA;Solid;Specificity;stem;Surface;Testing;Translating;Transrectal Ultrasound;tumor molecular fingerprint;ultrasound;United States National Institutes of Health;urinary;Urine;VIPR1 gene

PROJECT_TITLE: Noninvasive, Uniplex, Molecular, Pathomic Urinary Assay for Detection of Prostate Cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE This proposal will focus on developing novel technology and methods for a fully no-touch assessment of biomechanical properties of the cornea. The development of such a technique would significantly advance our understanding of corneal disorders, allow the development of novel clinical therapies and interventions, and improve the outcome of current surgical and therapeutic interventions.

PI_NAMEs: LARIN, KIRILL V (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acceleration;Achievement;Adoption;Agreement;Air;Algorithms;biomechanical test;Biomechanics;Cataract Extraction;Characteristics;Clinic;clinic ready;Clinical;clinical practice;clinical translation;Collagen;Connective Tissue;Cornea;Corneal Diseases;corneal epithelial wound healing;corneal surgery;crosslink;design;Detection;Development;Diagnostic;Diagnostic tests;Discipline;Disease;disease diagnosis;efficacy testing;Elasticity;elastography;Eye;Eye Development;Eye diseases;Frequencies;Glaucoma;Goals;Health;Human;Iatrogenesis;Image;improved;improved outcome;in vivo;innovative technologies;Intervention;Journals;Keratoconus;Keratoplasty;Knowledge;Laser In Situ Keratomileusis;Link;Local Therapy;Maps;Measurement;Measures;mechanical properties;Mechanics;Methods;Modeling;Myopia;Nature;new technology;next generation;novel;novel strategies;Office Visits;Operative Surgical Procedures;Optics;Oryctolagus cuniculus;Paper;Pathologic;Patients;Performance;personalized medicine;Pharmacotherapy;Phase;Physiologic Intraocular Pressure;Physiologic pulse;Physiological;Procedures;Property;Protocols documentation;Reporting;research clinical testing;Resolution;response;Retina;Routine Diagnostic Tests;Scanning;Sclera;screening;Source;spatiotemporal;Speed;submicron;success;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic procedure;Tissue Transplantation;Tissues;Touch sensation;translational applications;translational potential;Translations;Visual System;wound healing

PROJECT_TITLE: No-Touch High Resolution Optical Coherence Elastography of the Cornea using a Heartbeat


ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE OVERALL Alzheimer’s disease (AD) affects an estimated 5.8 million Americans, with patient numbers expected to triple over the next 30 years, yet there is no cure. There is an urgent need to stop, prevent, and treat AD. By establishing marmoset models of AD, we will be able to investigate primate-specific cellular and molecular root causes that underlie the pathogenesis and progression of AD and support future translational studies to accelerate the pace of bringing therapies to patients.

PI_NAMEs: CARTER, GREGORY W;RIZZO, STACEY J;SILVA, AFONSO C (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acceleration;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;analytical method;animal care;animal model development;assault;Behavioral;Bioinformatics;Biological;Biological Assay;Biology of Aging;Biometry;Brain;California;Callithrix;Clinical Protocols;Cognitive;Communities;comparative;Computational Biology;Data;data dissemination;data integration;data resource;Dedications;Dementia;Disease;Disease Progression;Early Onset Alzheimer Disease;Equipment;Evaluation;Event;Exhibits;Future;gene editing technology;Generations;Genes;Genetic;Genetic Diseases;Genetic Engineering;Genetic Risk;genetic variant;genomic signature;Genomics;Goals;Human;Image;in vivo;Intervention;Investigation;Knowledge;Late Onset Alzheimer Disease;Life;Link;Magnetic Resonance Imaging;model organism;Modeling;Molecular;multidisciplinary;multimodality;Mus;Mutation;Neurodegenerative Disorders;neurodevelopment;neuroimaging;neuropathology;novel;Onset of illness;open data;Outcome;Pathogenesis;Pathologic;Patients;PET/CT scan;Phenotype;Population;Positron-Emission Tomography;presenilin-1;prevent;Primates;Process;Protocols documentation;Radiochemistry;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;risk variant;statistics;Study models;The Jackson Laboratory;Therapeutic;tool;translational study;ultrasound;Universities;Validation;Work

PROJECT_TITLE: Generation, Characterization, and Validation of Marmoset Models of Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SILVA, AFONSO C (contact)

PROJECT_TERMS: Advisory Committees;Alzheimer's disease model;animal care;Animal Testing;Area;Bioinformatics;Breeding;Budgets;Callithrix;Communities;community engagement;Community Outreach;Data;data integration;Data Reporting;Development;Disease;Ensure;equipment acquisition;Evaluation;experimental study;Generations;Genetic Engineering;Goals;Institution;Knowledge Portal;Leadership;Measures;medical schools;meetings;Mission;Modeling;Monitor;multimodality;open data;outreach;Progress Reports;Protocols documentation;Reagent;Research;Research Personnel;Research Project Grants;Resources;Schedule;Science;success;symposium;The Jackson Laboratory;Time;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: CARTER, GREGORY W (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;behavioral outcome;Bioinformatics;Callithrix;Cohort Studies;Communities;computerized data processing;Data;Data Analyses;data format;data integration;data management;data reuse;Data Storage and Retrieval;design;Disease;empowerment;Ensure;FAIR principles;Foundations;Funding;Generations;Genome;genome sequencing;genome-wide;genomic data;Genomics;Goals;Human;human data;Human Genetics;Human Resources;Image;Knowledge Portal;Link;Maps;Measures;Modeling;Molecular;molecular pathology;Molecular Profiling;molecular scale;Multiomic Data;multiple omics;multiscale data;mutant;open data;Outcome;Phenotype;Population;Positioning Attribute;Process;Proteome;Proteomics;Protocols documentation;Quality Control;Research;Research Personnel;resilience;Resources;sharing platform;Software Tools;Standardization;Statistical Data Interpretation;Statistical Methods;therapeutic development;tool;transcriptome;transcriptome sequencing;uptake;Validation;whole genome

PROJECT_TITLE: Bioinformatics and Data Integration Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation

ORG_CITY: Minneapolis

ORG_NAME: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT

ORG_STATE: MN

PHR: Narrative Informal and family caregivers provide three quarters of the care for America’s dementia population at great economic and emotional cost to themselves. These caregivers experience significant stress due to the burdensome behaviors associated with dementia. A significant source of stress is associated with a common disease behavior known as wandering or elopement. The proposed research seeks to develop a comprehensive caregiver tracking assistant device to reduce these burdens, and to facilitate greater caregiver independence.

PI_NAMEs: ANDERSON, SHANE M. (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer's disease risk;American;Area;Behavior;Biomedical Technology;blind;Bluetooth;Caregiver Burden;caregiver stress;Caregivers;Caring;Cellular Phone;Cessation of life;Clinical Research;Clinical Trials;cloud based;Collaborations;common symptom;Companions;Complex;cost;Dementia;Dementia caregivers;Development;Devices;Disease;Disease Progression;Disorientation;Doctor of Philosophy;Economics;efficacy evaluation;efficacy trial;Elderly;Emotional;Endowment;Engineering;Environment;Evaluation;experience;Family Caregiver;Family member;Feedback;Focus Groups;Friends;Funding;Home;Hour;Human;human study;Impaired cognition;Individual;Indoor environment;informal care;informal caregiver;Injury;Lead;Life Expectancy;Location;Long-Term Care;loved ones;Marketing;Medical center;Mind;miniaturize;Minnesota;Monitor;nanodevice;new product development;Notification;Participant;Patients;peace;Persons;Phase;Population;Positioning Attribute;Prevalence;professor;prototype;psychologic;Public Health Schools;Radio;real time monitoring;Research;Risk;Self-Help Devices;Services;smartphone application;Source;Stress;Symptoms;System;Technology;Telephone;Testing;Transportation;trend;Universities;usability;Visual impairment;Walking;wireless;wireless fidelity

PROJECT_TITLE: Care Assistant for Family Caregivers of Persons with Dementia During Out of the Home Activities


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: This research addresses the substantial need to improve effectiveness in prevention of ankle sprains by introducing a smart shoe system that actively supports the ankle as needed without hindering natural ankle motion and provides an intuitive user interface with injury risk metrics to promote user adherence to clinical prescriptions. This solution is expected to substantially enhance the effectiveness of the current practice of passive ankle bracing or taping and contribute to the long-term goal of promoting ankle health.

PI_NAMEs: LEE, HYUNGLAE  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adherence;Algorithms;Ankle;Ankle Injuries;Atrophic;Behavioral;Behavioral Sciences;Benchmarking;biomechanical model;Biomechanics;Chronic;Clinic;Clinical;Clinical Trials;clinically relevant;clinically significant;compliance behavior;computerized data processing;Data;design;Development;Devices;Effectiveness;Engineering;Ensure;Evaluation;experience;Feedback;follow-up;foot;Goals;Health;human-in-the-loop;improved;Individual;Injury;injury prevention;innovation;intelligent algorithm;intervention effect;Intuition;Long term disability;Long-Term Effects;Lower Extremity;machine learning algorithm;Mechanics;Mind;Mission;mobile application;Modeling;Motion;Muscle;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nonlinear Dynamics;novel strategies;Observational Study;patient oriented;Patients;Performance;Persons;Physical activity;Populations at Risk;prediction algorithm;preservation;prevent;Prevention;Prevention strategy;Public Health;Quality of life;Recommendation;Recording of previous events;Recurrence;Research;Risk;risk prediction;sensor;Shoes;soft tissue;Sports;Sprain;System;Systems Development;Systems Integration;theories;Time;wearable data;wearable sensor technology;wireless

PROJECT_TITLE: SCH: Smart User-Effective Data-Enabled (SUEDE) Shoe for Ankle Injury Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Contraception/Reproduction;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

PI_NAMEs: HOMANICS, GREGG E. (contact)

PROJECT_TERMS: Abbreviations;Age Months;Alzheimer's Disease;Alzheimer's disease model;Animals;Assisted Reproductive Technology;Astrocytes;Biomedical Research;Birth;Brain;Brain Diseases;Callithrix;Callithrix jacchus jacchus;Cell Differentiation process;Cell Line;Cervical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost;CRISPR/Cas technology;design;Development;DNA sequencing;Early Onset Alzheimer Disease;Electroporation;Embryo;Embryo Transfer;Fibroblasts;Follicle Stimulating Hormone;gene-editing approach;Generations;Genes;Genetic Engineering;Genome;Genotype;Germ Lines;Goals;Gonadotropins;high risk;Human;Human Chorionic Gonadotropin;improved;In Vitro;Induced Neurons;Infant;inhibin;Knock-in;Knock-out;Late Onset Alzheimer Disease;Libraries;Methodology;Methods;Microinjections;model organism;Modeling;Modification;mosaic;Mosaicism;Mus;nerve stem cell;Neurobiology;Neurons;Neurosciences;nonhuman primate;novel;novel strategies;offspring;Oocytes;Ovarian Stimulations;Phenotype;PMSG (Gonadotropins);Pregnancy;Production;Reagent;risk variant;Serum;Services;Speed;Surrogate Mothers;Techniques;Technology;Testing;translational neuroscience;Validation;zygote

PROJECT_TITLE: Genetic Engineering Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acclimatization;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Anatomy;Anesthesia procedures;Animals;arterial stiffness;awake;behavior test;Behavioral;Biological Assay;Biological Markers;Birth;Blood;Blood - brain barrier anatomy;Brain;Callithrix;Cerebrospinal Fluid;Clinical;clinical biomarkers;Cognitive;cognitive testing;Conscious;cytokine;Data;data acquisition;data analysis pipeline;Data Collection;Disease;Disease Progression;early onset;Early Onset Alzheimer Disease;Ensure;Evaluation;experimental study;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Funding;Generations;Genetic Risk;glucose metabolism;healthy aging;Human;Image;Infant;Knowledge;life span;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Methods;Mission;Modality;Modeling;Motor;multimodality;National Institute on Alcohol Abuse and Alcoholism;neuroimaging;neuropathology;new therapeutic target;novel therapeutics;Onset of illness;Outcome;Pathogenicity;Pathologic;Phenotype;Plasma;Positron-Emission Tomography;Proteomics;Protocols documentation;Recovery;Research;Research Project Grants;Rest;restraint;risk variant;Sampling;Senile Plaques;serial imaging;Serum;Staging;Standardization;Structure;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic Intervention;Time;trait;transcriptomics;Translational Research;translational study;Ultrasonography;Validation;Work;β-amyloid burden

PROJECT_TITLE: Multimodal Disease Characterization Core


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE For non-model organisms, a lack of gene information is a significant hinderance to understanding the biology of the organism. We have two complementary research programs to increase our information on gene function in non-model fungal pathogens. 1) to use computational methods to predict gene function, and 2) to use molecular genetics methods to test specific hypotheses about network remodeling in the non-model fungi Candida albicans and Candida auris.

PI_NAMEs: OMEARA, TERESA R. (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Affect;Biological;Biology;Candida albicans;Candida auris;Case Study;Cells;Communities;Complication;Computer Models;Computing Methodologies;Data;Dissection;Evolution;fungus;gene discovery;gene function;Genes;Genetic Screening;Goals;insight;interest;Knowledge;Methods;model building;Modeling;Molecular;Molecular Genetics;Organism;pathogenic fungus;predictive modeling;programs;Proteins;Research;Role;Signal Transduction;Stimulus;Testing;transcription factor;transcriptomics;Work

PROJECT_TITLE: Discovery of gene function and dissection of network re-wiring in non-model fungi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


PI_NAMEs: STRICK, PETER  (contact)

PROJECT_TERMS: Adherence;age related;age-related disease;aged;aging related;Albumins;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Anesthesia procedures;animal care;Animal Experimentation;Animal Model;Animals;Autopsy;biobank;Biomedical Research;Biopsy Specimen;Blood;Body Weight decreased;Breeding;Callithrix;Callithrix jacchus jacchus;Cardiovascular Diseases;Caring;Cataloging;Cerebrum;Chronic Kidney Failure;Code;Collection;Common Core;comorbidity;Creatinine;Dedications;Deposition;Diabetes Mellitus;Disease;Embryo Transfer;enhanced care;Enrollment;Ensure;Fibroblasts;Frequencies;Gastrointestinal Diseases;Generations;genetic pedigree;gut microbiome;Haplorhini;Health;Health Promotion;Hematocrit procedure;Hemoglobin;Human;in vivo;Individual;Infant Care;Insulin Resistance;life span;Liquid substance;Longitudinal Studies;Macular degeneration;Malignant Neoplasms;Managed Care;Metabolic dysfunction;Modeling;Monitor;Neurosciences;nonhuman primate;Obesity;Oocytes;Operative Surgical Procedures;Outcome;pathological aging;Personal Satisfaction;Pregnancy;Primates;Procedures;programs;Records;Recovery;repository;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;sample collection;Sampling;Services;skin biopsy;Study models;Thinness;Tissue Sample;Tissues;Training;Universities;Validation;Veterinarians;welfare;Work

PROJECT_TITLE: Veterinary and Colony Management Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: RIZZO, STACEY J (contact)

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Age;Age of Onset;age related changes;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;analytical method;Anatomy;Behavioral;Biological Markers;Biological Models;Birth;Brain;Callithrix;Callithrix jacchus jacchus;case control;Cells;Cerebrovascular Circulation;Clinical;Clinical Data;Cognitive;Communities;cytokine;Data;design;differential expression;Disease;disease diagnosis;disease model;Disease Progression;Early identification;Early Onset Alzheimer Disease;effective therapy;Emotional;Evaluation;Event;Fibroblasts;Foundations;Future;Generations;Genetic;Genetic Engineering;Genetic Risk;Goals;healthy aging;Human;Impaired cognition;infancy;Infant;Intervention;Investigation;Knowledge;Knowledge Portal;Life;life span;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Modeling;Molecular;Molecular Profiling;Motor;multimodality;multiple omics;mutant;Mutation;National Institute on Alcohol Abuse and Alcoholism;neural;Neuroanatomy;neurodevelopment;neuroinflammation;Neurons;neuropathology;novel;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Patients;Phase;Phenotype;Physiological;Positron-Emission Tomography;potential biomarker;pre-clinical;presenilin-1;prevent;Prevention;Primates;Process;Proteome;Research;Resources;risk variant;Sampling;skin biopsy;social;Staging;Study models;System;targeted treatment;tau Proteins;tau-1;Tissues;transcriptome;translational approach;Validation;Variant;Work

PROJECT_TITLE: Project 1: Identification of Early Life molecular determinants of Alzheimer's Disease pathogenesis


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Clinical Research;Osteoporosis;Patient Safety;Precision Medicine;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Osteoporosis drug therapy reduces fractures that cause disability, entry into nursing homes, and premature death among older adults, but long-term exposure to many treatments for osteoporosis has been linked to serious, rare side effects. Better understanding of the benefits and harms of different long-term osteoporosis drug therapy strategies will help to guide treatment decisions for older adults and ultimately improve patient health outcomes. Additionally, the proposed work will establish a unique multinational data partnership that can be re-used to conduct timely studies on the effects of osteoporosis drug therapy in older adults.

PI_NAMEs: CADARETTE, SUZANNE ;HAYES, KALEEN NICOLE (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Adherence;Adverse event;adverse event risk;Age;aged;Alendronate;Algorithms;Benefits and Risks;bisphosphonate;Canada;Cessation of life;Characteristics;Clinical;Clinical assessments;Clinical Data;clinical predictors;Clinical Trials;Communities;comparative;Data;data cleaning;Data Set;Data Sources;Decision Making;disability;Drug usage;Educational workshop;Electronic Health Record;epidemiology study;evidence base;experience;Exposure to;Femoral Fractures;follow-up;Forteo;Fracture;fracture risk;frailty;Future;Geographic Locations;Goals;Guidelines;Harm Reduction;Health;Healthcare;high risk;Hip Fractures;Holidays;human old age (65+);improved;Individual;individualized medicine;International;Joints;Knowledge;Length;Life Expectancy;Link;Long-Term Effects;Longitudinal Studies;Medicare;Medicare claim;men;Methods;Modeling;National Institute on Aging;novel;Nursing Homes;older adult;Ontario;Oral;Osteoporosis;osteoporosis with pathological fracture;Outcome;Pain;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Population;prediction algorithm;Prediction of Response to Therapy;premature;prevent;Prevention;Raloxifene;randomized trial;Recommendation;Recording of previous events;Research;Research Personnel;Risk;risk minimization;risk prediction model;risk/benefit ratio;secondary analysis;sex;side effect;study population;Subgroup;System;therapy duration;Time;treatment pattern;treatment strategy;Woman;Work;Zoledronate

PROJECT_TITLE: Benefits and Harms of Long-term Osteoporosis Pharmacotherapy: Impact of Treatment Length, Type, Switching, and Holidays


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;analytical method;Animal Model;Autopsy;Behavioral;Bioinformatics;Biological;Biological Markers;Biological Models;Callithrix;Cell model;Clinical;Clinical Research;clinically relevant;Cognitive;Cohort Studies;Communities;Complement;Data;Data Aggregation;data integration;data modeling;data-driven model;Dementia;dimension reduction;Disease;disease model;Disease Outcome;Disease Progression;Drug Targeting;efficacy testing;Engineering;Evaluation;Event;Foundations;functional genomics;Future;Generations;Genetic;genetic analysis;genetic association;Genetic Engineering;genetic variant;Genetic Variation;Genome;genome-wide;genomic data;Genomics;Genotype;Goals;Human;human data;Human Genetics;human study;Image;Impaired cognition;in vivo imaging;Knowledge Portal;Laboratories;Late Onset Alzheimer Disease;life span;Link;Methods;Modeling;Molecular;molecular marker;molecular scale;mouse model;multi-scale modeling;multimodality;multiple data types;multiple omics;neuropathology;nonhuman primate;Outcome;Outcome Study;Pathology;Pathway interactions;Phenotype;phenotypic data;Population;pre-clinical research;preclinical efficacy;preclinical study;presenilin-1;Primates;Process;Proteins;Research;risk variant;Rodent Model;Serum;Statistical Models;Structure;Study models;targeted treatment;Testing;Tissues;Validation;Variant;whole genome;Work

PROJECT_TITLE: Project 2: Identify and enhance LOAD-related signatures in outbred and genetically-engineered marmosets


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hypertension;Kidney Disease;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Chronic kidney disease (CKD) is a highly prevalent condition characterized by chronic over-activation of the sympathetic nervous system that contributes to increased cardiovascular mortality risk. Elucidating the role of sympatho-inhibition as a mechanism underlying the beneficial effects of mindfulness-based interventions may identify a physiologic pathway by which mindfulness-based interventions may improve clinical outcomes in patients with CKD. Integration of noninvasive optimization techniques such as transcutaneous vagus nerve stimulation may enhance the beneficial effects of mindfulness interventions on mechanistic and clinical endpoints, and may emerge as a novel therapeutic approach to ameliorating sympathetic over-activity and cardiovascular risk in CKD.

PI_NAMEs: PARK, JEANIE  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: active control;Acute;Address;Adrenergic alpha-Antagonists;Adrenergic beta-Antagonists;afferent nerve;African American;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Autonomic nervous system;Baroreflex;Binding;Blood Pressure;blood pressure control;blood pressure reduction;Brain Stem;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cervical;cholinergic;Chronic;Chronic Kidney Failure;Circadian Dysregulation;Circadian Rhythms;Clinical;Clonidine;combat;Controlled Clinical Trials;Data;design;Development;Devices;effective therapy;Efferent Neurons;Electric Stimulation;Equilibrium;Event;experimental study;Failure;Fatigue;Health;heart rate variability;hemodynamics;high risk;Hour;Human;Hyperlipidemia;Hypertension;improved;Inferior;Inflammation;Insulin Resistance;Intervention;Knowledge;Link;Masks;Measurement;Measures;men;Metabolic;Methods;mindfulness;mindfulness intervention;mindfulness meditation;mindfulness-based stress reduction;mortality;mortality risk;Muscle;Nerve;Nerve Fibers;Nervous System Physiology;novel;novel strategies;novel therapeutic intervention;Nucleus solitarius;Orthostatic Hypotension;Outcome;Output;Parasympathetic Nervous System;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Population;profiles in patients;programs;Randomized;Randomized Controlled Clinical Trials;Regulation;Renal function;Rest;Risk Reduction;Role;Safety;Self Administration;side effect;Sympathetic Nervous System;Sympatholytics;Techniques;Testing;Therapeutic;vagus nerve stimulation;Vagus nerve structure

PROJECT_TITLE: Sympatho-inhibition with Mindfulness in Chronic Kidney Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Acceleration;Affect;age related;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;analytical method;Animal Model;Animals;Appearance;Behavior;Behavioral;Binding;Bioinformatics;Biological Markers;Callithrix;Callithrix jacchus jacchus;Clinical;Cognitive;Communities;comparative;data integration;Dementia;Disease;Disease Progression;early detection biomarkers;Early identification;Early Onset Alzheimer Disease;effective therapy;Engineering;Evaluation;Future;Generations;Genes;Genetic;Genetic Engineering;Genetic Risk;genetic variant;genome wide association study;genome-wide analysis;healthy aging;Human;human model;Intervention;Investigation;Knowledge;Knowledge Portal;Late Onset Alzheimer Disease;life span;Longitudinal Studies;Measures;member;Modality;Modeling;Molecular;multimodality;Mutation;Neurodegenerative Disorders;neuropathology;new therapeutic target;novel;Odds Ratio;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Phenotype;Play;Population;presenilin-1;prevent;Primates;Research;Resources;risk variant;social;Staging;Testing;Therapeutic;therapeutic development;Universities;Validation;Variant;Work

PROJECT_TITLE: Project 3: Multi-modal phenotypic Characterization of marmoset models of Late Onset Alzheimer's Disease


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The paucity of genetic tools for manipulation of Chlamydia trachomatis has significantly hindered our ability to define bacterial and host factors that facilitate host cell invasion, a process that is essential for bacterial proliferation and disease progression. This proposal will employ cutting-edge genetics, cellular, and molecular strategies to elucidate the molecular mechanisms underlying how TmeA/N-WASP interactions promote bacterial uptake and furthermore, will examine the necessity and function of other prepackaged type III secreted effectors and uncover their roles in coordinating membrane remodeling to facilitate host cell invasion. Collectively our studies will identify novel potential targets for blocking bacterial entry into host cells.

PI_NAMEs: WEBER, MARY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Actins;Address;ANGPTL2 gene;Antibiotic Therapy;Bacteria;Bacterial Infections;Binding;Blindness;Cells;Cervical;Chlamydia;Chlamydia trachomatis;Complex;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Development;Disease Progression;Disparate;EMS1 gene;Ensure;Filopodia;Genetic;Glean;Goals;Guanosine Triphosphate Phosphohydrolases;Human;Impairment;Incidence;Infection;Injections;Integration Host Factors;Invaded;knock-down;Knowledge;Laboratories;Left;Measures;Mediating;Membrane;Modeling;Molecular;mutant;Nature;novel;novel therapeutic intervention;pathogen;Pathogenesis;Pathway interactions;Physiological;polymerization;Polymers;Prevalence;Process;Proliferating;Proteins;recruit;Recurrence;Role;Scaffolding Protein;Sexual Transmission;Signal Pathway;Signal Transduction;Site;tool;Type III Secretion System Pathway;uptake

PROJECT_TITLE: The role of secreted effector proteins in Chlamydia trachomatis invasion

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eating Disorders;Health Services;Mental Health;Mental Illness;Nutrition;Pediatric;Serious Mental Illness

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: The aim of this study in response to PAR-21-130 is to determine if online Guided Self-Help Family-based Treatment is as effective and more efficient than Family-based Treatment provided via teleconferencing for adolescents with anorexia nervosa.

PI_NAMEs: LOCK, JAMES D (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Address;Adolescent;Adoption;Anorexia Nervosa;Attitude;Behavior;Blinded;Body Weight;Case Series;Child;Clinic;Clinical;Clinical Trials;Cognition;comparative effectiveness study;cost;Data;Disease remission;Divorce;Dose;DSM-V;Early treatment;Eating;Eating Disorders;effective therapy;Effectiveness;effectiveness testing;efficacious treatment;empowerment;evidence base;experience;Family;family structure;Family Study;Feasibility Studies;flexibility;follow-up;Funding;Health Services Accessibility;Health system;Healthcare Systems;hybrid type 1 design;implementation facilitators;improved;improved outcome;Incidence;Individual;Intention;Intervention;Interview;Measures;Mediating;Mediator;Morbidity - disease rate;mortality;Obsession;Ontario;Outcome;Parents;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Persons;Pilot Projects;preventive intervention;primary outcome;Randomized;reconstitution;Recovery;recruit;Resistance;response;secondary outcome;Self Efficacy;self help;service intervention;severe mental illness;Severities;Single Parent;Site;Structure;systemic barrier;Teleconferences;Testing;Time;treatment comparison;treatment effect;Treatment Effectiveness;treatment program;treatment services;treatment site;Video Recording;Videoconferencing;Weight;Weight Gain;Youth

PROJECT_TITLE: Confirming the Effectiveness and Efficiency of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Genomic technologies fail to directly capture the molecular complexity and plasticity of the tumor proteome that dictates cancer initiation, progression, and therapeutic response. However, methodologies and tools to quantitatively visualize and identify the molecular and biochemical features of tumor cell dynamics to inform on therapeutic mechanism of action and motivate targeted therapy and diagnostic discovery are needed. This proposal describes the creation of the Probe Enabled Activity Reporting (PEAR) platform technology that leverages chemical biology approaches to monitor proteome driven changes necessary for tumor cell function as a means to predict therapeutic responses and discover unexplored liabilities.

PI_NAMEs: BRADY, DONITA C (contact);BURSLEM, GEORGE ;BUSINO, LUCA ;GADE, TERENCE P;WITZE, ERIC S.

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Acceleration;Aftercare;anti-cancer research;Award;Back;Basic Science;behavioral response;bench to bedside;Biochemical;Biological Assay;Biological Models;Biology;Biomedical Research;Bypass;Cancer Biology;cancer cell;cancer genetics;cancer genomics;cancer initiation;Cancer Model;Cancer Patient;cancer therapy;cancer type;Cell Line;Cell Physiology;Chemicals;Chemistry;chemoproteomics;Clinical;clinical decision-making;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Coupled;Coupling;Data;design;Development;Diagnostic;diagnostic technologies;Discipline;Disease;driver mutation;drug development;drug discovery;Elements;empowerment;Engineering;Epigenetic Process;Foundations;Future;Gene Mutation;gene product;Generations;Genetic;genetic approach;genetic predictors;genetic profiling;Genomic approach;Genomics;Goals;imaging approach;imaging probe;improved;Individual;innovation;innovative technologies;insight;Investments;Label;Link;Malignant - descriptor;Malignant Neoplasms;Maps;Measurement;Methodology;Methods;Modality;Molecular;Monitor;Mutation;neoplastic cell;new technology;new therapeutic target;Normal Cell;novel;novel therapeutics;Oncogene Activation;Oncogenic;Outcome;patient subsets;Patient-Focused Outcomes;Patients;Post-Translational Protein Processing;precision medicine;precision oncology;Prediction of Response to Therapy;Primary carcinoma of the liver cells;Protein Biochemistry;protein degradation;protein function;Proteins;Proteome;Proteomics;Reagent;Reporting;Research;Research Personnel;Resources;response;Sampling;Signal Pathway;Solid Neoplasm;targeted treatment;Technology;technology platform;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Tissue Banks;Tissue Sample;tool;transcriptomics;Translation Alteration;translational potential;Translations;treatment response;treatment strategy;tumor;Tumor Biology;Tumor Cell Biology;Visit;Visualization

PROJECT_TITLE: Unlocking the Chemical Space of Cancer-Associated Perturbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE – OVERALL COMPONENT Benign Prostatic Hyperplasia (BPH) is the most common cause of Lower Urinary Tract Symptoms (LUTS) in men, yet we understand little about how it arises and progresses to cause LUTS. We propose an integrated O’Brien Center in which we will develop a molecular and cellular characterization of BPH, akin to the human tumor atlas, and will lead us closer to identify BPH specific treatments by uncovering its pathophysiology.

PI_NAMEs: BROOKS, JAMES D. (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: 3-Dimensional;Affect;associated symptom;Atlases;Automobile Driving;Benign;Benign Prostatic Hypertrophy;bioimaging;Bioinformatics;Biology;cell growth;Cell Nucleus;Cell Physiology;cell type;Cells;Clinical;Collaborations;Communication;Communities;CXCL13 gene;Data;Data Analyses;data de-identification;Development;Dimensions;Disease;Elements;Embryo;Embryonic Development;Ensure;Epithelial Cells;Epithelium;experience;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;Gene Expression Profiling;genomic data;Goals;graduate student;Growth;Growth and Development function;Heterogeneity;Histologic;histological image;Histology;Human;human disease;Image;Immune;Immune response;Immunohistochemistry;improved;indexing;Infiltration;Inflammation;Inflammatory;International;Investigation;Lead;lower urinary tract symptoms;Magnetic Resonance Imaging;man;men;Modeling;Molecular;molecular subtypes;Multiplexed Ion Beam Imaging;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel therapeutic intervention;novel therapeutics;older men;Pathogenesis;Pathway interactions;Patients;Pilot Projects;Play;Population;prevent;programs;Proliferating;Prostate;prostate enlargement;Prostatic Diseases;Prostatic Urethra;Radiology Specialty;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;response to injury;Role;Sampling;Science;Scientist;senescence;Services;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Stromal Cells;success;Symptoms;Technology;Testing;Therapeutic;three-dimensional modeling;Time;Tissue Expansion;Tissues;Training;transcriptomics;translational scientist;tumor;tumor-immune system interactions;undergraduate student;urinary;urologic;Urologic Diseases;Urology

PROJECT_TITLE: Stanford O'Brien Urology Research Center


PROJECT_TERMS: Advisory Committees;Area;authority;Benign;Clinical;Collaborations;Communication;Communities;Conflict of Interest;cost effectiveness;Decision Making;design;Education;Ensure;Evaluation;Funding;General Population;Goals;Guidelines;Information Dissemination;Institution;Leadership;meetings;member;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Occupational activity of managing finances;Office of Administrative Management;Pilot Projects;Process;Productivity;programs;Recording of previous events;Reporting;Research;Research Personnel;Resources;Services;success;Training;Training Activity;Universities;urologic;Urology;Work

PROJECT_TITLE: Administrative Core


PHR: Narrative Biophysics is spurring tomorrow’s innovations in the life sciences and medicine by melding quantitative, physics-based mindsets with biology’s most pressing multiscale problems. The interdisciplinary Stanford Biophysics Program empowers graduate students from diverse backgrounds to tackle these problems, with support from faculty from 21 departments in one of the world’s most pioneering institutions. Overall, the Program combines coursework, mentored research, and a spectrum of extracurricular activities to promote trainee creativity and success in a rigorous atmosphere of inclusion, diversity, and high research conduct and ethics.

PI_NAMEs: HUANG, KERWYN C. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biophysics;Molecular;Training Programs

PROJECT_TITLE: Molecular Biophysics Training Program at Stanford

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

PI_NAMEs: WEST, ROBERT B (contact)

PROJECT_TERMS: Antibodies;Atlases;Benign;bioimaging;Biopsy;Blood;Cancer Center Planning Grant;Cells;Communities;Consent;Cryopreservation;Data;Database Management Systems;Databases;demographics;Diagnosis;digital;Education;experience;Formalin;Freezing;Histology;Image;Immunohistochemistry;Infrastructure;International;laser capture microdissection;Lasers;Link;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Metals;Methods;Microdissection;Multiplexed Ion Beam Imaging;Paraffin Embedding;Pathology;Patients;Plasma;Process;programs;Prostate;prostate biopsy;Prostatectomy;Qualifying;Quality Control;Radical Prostatectomy;Research;Research Personnel;Research Project Grants;Resolution;Resources;Scanning;Serum;Services;Stains;Standardization;Symptoms;Technology;Time;Tissue Embedding;Tissue Microarray;Tissue Procurements;Tissues;Training;training opportunity;Urology

PROJECT_TITLE: Biospecimen/Bioimaging Core