NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There are no effective treatments for patients with advanced cholangiocarcinoma (CCA); less than 10% of patients survive a year after diagnosis. Our data support the hypothesis that combining gemcitabine, a current standard of care for CCA, with a BETi + a PARPi comprises effective therapy for CCA even in tumor models that are insensitive to gemcitabine. Since mechanistic data in this application show that BETi decrease expression of DNA repair proteins that contribute to gemcitabine resistance and that PARPi augment this effect, we will determine the extent to which sequential administration of a BETi + PARPi decreases levels of DNA repair proteins and subsequent administration of gemcitabine produces durable tumor regressions.

PI_NAMEs: YOON, KARINA J (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acetylation;advanced disease;Affect;Analysis of Variance;Apoptosis;Bile Duct Carcinoma;Binding;Binding Sites;BRCA2 gene;BRCA2 Protein;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Caring;CASP3 gene;Cells;Characteristics;chemotherapy;Cholangiocarcinoma;Cisplatin;clinical efficacy;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;Complex;cytotoxicity;Data;Diagnosis;Disease remission;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA sequencing;DNA-dependent protein kinase;Drug Combinations;Drug resistance;effective therapy;efficacy evaluation;Event;FGFR2 gene;Fluorouracil;Future;gemcitabine;Gene Expression;gene product;Genes;Genetic;Genetic Transcription;genome sequencing;Goals;Hematopoietic;Hepatic;Histones;homologous recombination;improved;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;interest;KRAS2 gene;Laboratories;Lesion;Literature;liver function;Lysine;Mediating;Modeling;Molecular;Mutation;Nature;Neoplasm Metastasis;novel;Oncogenes;overexpression;Paclitaxel;Parents;Pathway interactions;patient derived xenograft model;Patients;Pattern;peripheral blood;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;Proliferation Marker;Protein Family;Proteins;Regimen;relapse patients;Renal function;Reporting;Resistance;Resistance development;response;standard of care;subcutaneous;Survival Rate;synergism;targeted agent;Tertiary Protein Structure;Therapeutic;Toxic effect;TP53 gene;transcriptome sequencing;Treatment Efficacy;treatment group;Treatment Protocols;tumor;tumor DNA;Tumor Volume;whole genome;Work;XRCC5 gene

PROJECT_TITLE: Mechanism-based combination therapy for cholangiocarcinoma


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This proposal will evaluate a new therapeutic strategy to control joint-level inflammation following acute joint trauma or within an osteoarthritic joint. In our approach, we seek to modify the local metabolism of an injured joint by delivering an immunomodulatory enzyme. With this enzyme, we aim to produce anti-inflammatory metabolites within the diseased joint, and thereby control joint pain and reduce pathologic remodeling.

PI_NAMEs: ALLEN, KYLE D (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acute;Address;Affect;allodynia;Anti-Inflammatory Agents;Antiinflammatory Effect;Arthralgia;arthropathies;Attenuated;Behavior;Behavioral;Binding;carbohydrate binding protein;carbohydrate receptor;Cells;Chimeric Proteins;Chronic;Chronic Disease;cytokine;Data;Degenerative polyarthritis;disability;Disease;Dose;Drug Delivery Systems;Enzymes;extracellular;Extracellular Matrix;Future;Gait;Galectin 3;Histology;Homeostasis;Human;IL6 gene;Immune;Immune system;immunoengineering;immunoregulation;improved;Inflammation;inflammatory pain;innovation;Interleukin-6;Intra-Articular Injections;joint destruction;joint inflammation;joint injury;Joints;Knee;Knee Osteoarthritis;Kynurenine;Limb structure;Macrophage;Medial meniscus structure;Mediator;meniscal tear;meniscus injury;Metabolic;Metabolism;Modeling;novel;novel therapeutic intervention;osteoarthritis pain;Pain;Pathogenesis;Pathologic;Pathway interactions;Patients;Persistent pain;Pharmaceutical Preparations;Play;prevent;Process;Proteins;Rattus;residence;Risk;Rodent;Rodent Model;Role;Signal Transduction;Source;Symptoms;Synovial Fluid;synthetic drug;System;T-Lymphocyte;Tactile;Therapeutic;Time;Tissues;Trauma;Traumatic Arthropathy;treatment strategy;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway

PROJECT_TITLE: Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Infant Mortality;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The rapid diagnosis of bacterial sepsis and timely initiation of antibiotics is crucial for reducing neonatal mortality and improving morbidity. However, subtle clinical signs and inaccurate laboratory tests make rapid diagnosis especially difficult in infants. We will develop a novel infant sepsis early recognition system to improve clinician recognition by improving situation awareness, with a goal of improving infant sepsis outcomes in a future clinical trial.

PI_NAMEs: GRUNDMEIER, ROBERT W (contact);HARRIS, MARY CATHERINE

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;age group;Antibiotics;antimicrobial;Awareness;Bacteremia;Benchmarking;Caring;Childhood;Clinical;clinical care;Clinical Data;clinical implementation;Clinical Informatics;Clinical Trials;comorbidity;Complex;Comprehension;Consensus;Critical Illness;Data;Data Display;data modeling;Data Science;Decision Making;Decision Support Systems;Development;Devices;Diagnosis;diagnostic strategy;Discipline;Early Diagnosis;Education;Effectiveness;effectiveness measure;Electronic Health Record;Engineering;Ensure;Environment;Evaluation;Evaluation Methodology;experience;experimental study;Foundations;Future;Global Awareness;Goals;Health;health information technology;healthcare burden;high risk;high risk infant;Hospitalization;Hour;Human;improved;improved outcome;Infant;infant infection;infant morbidity/mortality;Infant Mortality;infant outcome;Infectious Diseases Research;Information Systems;innovation;Intervention;Knowledge;Laboratories;Machine Learning;Measures;Medical;Medical center;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Neonatal Intensive Care Units;Neonatal Mortality;neonatal sepsis;Neonatology;novel;Nurses;Outcome;Output;Patients;Pediatric Hospitals;Philadelphia;Physicians;Population;Positioning Attribute;predictive modeling;Prevention;Process;prototype;rapid diagnosis;Recommendation;Registries;Research;Research Personnel;Resources;Risk;risk prediction model;Safety;Sepsis;simulation;Site;support tools;Survivors;System;Techniques;Testing;Training;treatment and outcome;Uncertainty;United States National Library of Medicine;usability;user centered design;web services;Work

PROJECT_TITLE: Situation Awareness to Improve Infant Sepsis Recognition in the Presence of Clinical Uncertainty

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The discoveries we make will continue to inform the fundamental biology of heart regeneration, and they will directly relate to ideas and methods to enhance regeneration and reduce the incidence of heart failure in humans. They are also likely to extend beyond cardiovascular biology and have relevance to the repair of other tissues.

PI_NAMEs: POSS, KENNETH D (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adult;American;Biological Models;Biology;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;Cicatrix;Excision;Gene Expression Regulation;healing;Heart;Heart failure;Heart Ventricle;Human;Incidence;Injury;innovation;Laboratories;Mammals;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Principal Investigator;programs;regenerative;Regenerative response;repaired;Resolution;socioeconomics;teleost;Tissues;tool;United States;Viral Vector;Zebrafish

PROJECT_TITLE: Leveraging zebrafish models to dissect and enhance heart regeneration


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: In this application, we will test the overarching hypothesis that cerebrospinal fluid drains via skull channels into the cranial bone marrow. We will examine the importance of this outflow for activation of hematopoietic cells in the skull in mice with bacterial meningitis.

PI_NAMEs: LIN, CHARLES P.;MOSKOWITZ, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Acute;Anatomy;Antigens;arachnoid villi;Area;Bacteria;Bacterial Meningitis;Biological Assay;bioluminescence imaging;Blood;Blood - brain barrier anatomy;Blood Vessels;Bone Marrow;Bone Marrow Cells;Brain;brain health;brain magnetic resonance imaging;Bypass;Cells;Central Nervous System;Central Nervous System Diseases;Cephalic;Cerebrospinal Fluid;Cervical lymph node group;Circulation;cisterna magna;Clinical;cortical bone;cranium;Custom;Data;density;Drainage procedure;Emergency Situation;Environment;Event;Head;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Image;image guided;Immune;Immunology;Infection;Inflammation;Inflammatory;Intercellular Fluid;Intravenous;intravital imaging;intravital microscopy;irradiation;Knowledge;Label;Leukocytes;long bone;Lymphatic;lymphatic vessel;Marrow;Meningeal;Meningeal lymphatic system;Meninges;Meningitis;migration;millimeter;Molecular;Mus;Neurologic;neurological recovery;Neurosciences;non-invasive imaging;novel;Phenotype;programs;response;Route;Sampling;Shapes;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;Streptococcus pneumoniae;Structure of choroid plexus;Surveys;System;Testing;Time;Toll-like receptors;tool;Tracer;Veins;Venous;Ventricular;wasting;Work

PROJECT_TITLE: Local Skull Marrow Sensing and Response to CNS Inflammation

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_CITY: IRVINE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative A wearable continuous monitor will be developed for reporting and predicting physiological state during shock and sepsis. The technology comprises a minimally-invasive multi-analyte sensor and a flexible wearable patch for pulse oximetry. The technology will be tested in a porcine model of hemorrhagic injury and resuscitation.

PI_NAMEs: BOTVINICK, ELLIOT LAWRENCE (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Address;Admission activity;Alkalosis;American;Area;Blood;casualty care;clinical research site;combat casualty;Continuity of Patient Care;Control Groups;Data;data exchange;Department of Defense;design and construction;Devices;Diabetes Mellitus;Diagnosis;Early Diagnosis;Educational workshop;Environment;Feedback;flexibility;Glucose;glucose sensor;glycemic control;Goals;Grant;Health Sciences;Health Services Research;Heart Rate;heart rate monitor;heart rhythm;hemodynamics;Hemoglobin;Hemorrhage;Hospitals;Human;human subject;Hybrids;improved;improved outcome;In Vitro;in vivo;injured;Injury;interest;International;Intervention;Intramuscular;Lactic Acidosis;Legal patent;Measurement;Measures;Mechanics;Medical;Metabolic;minimally invasive;Monitor;Morbidity - disease rate;mortality;National Institute of Biomedical Imaging and Bioengineering;Obstructive Lung Diseases;operation;Operative Surgical Procedures;Outcome;Oxygen;Patients;Performance;Peripheral;Physiologic Monitoring;Physiological;Point of Care Technology;point of injury;porcine model;Process;programs;prolonged field care;Publishing;Pulse Oximetry;real time monitoring;Recommendation;Reporting;Research;research and development;Respiratory Acidosis;Resuscitation;Risk;Running;sensor;sensor technology;Sepsis;Shock;Signal Transduction;Skin;standard of care;subcutaneous;Symptoms;System;Technology;Telemetry;Testing;Time;Tissues;tool;Training;transmission process;Transportation;Trauma;trauma care;trend;Triage;United States National Institutes of Health;University Health Services;vasoconstriction;wearable device;wireless;wireless transmission;Work

PROJECT_TITLE: Metabolic and hemodynamic sensor for monitoring throughout the continuum of care

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Male germ cell differentiation relies on expressing the correct suite of proteins at the correct time, which is achieved via regulated mRNA translation. This work aims to determine how a novel RNA binding protein regulates the timing and location of mRNA translation in meiotic germ cells. The outcome of this work may improve our ability to treat male infertility and develop male contraceptives along with informing on the fundamental process of mRNA translation.

PI_NAMEs: SNYDER, ELIZABETH M, (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Accounting;Award;Binding Proteins;Cell Differentiation process;Cells;Characteristics;Complex;Cytoplasmic Granules;Data;Defect;Development;experimental study;Fertility;Genetic Models;Germ Cells;Goals;improved;insight;Laboratories;Lead;Location;Male Contraceptive Agents;male fertility;Male Infertility;Mass Spectrum Analysis;Mediating;Meiosis;member;Messenger RNA;Methods;Modality;Modeling;Molecular;molecular phenotype;mRNA Translation;multiple omics;mutant;novel;Outcome;outcome disparities;Positioning Attribute;Post-Transcriptional Regulation;Procedures;Process;Proteins;Proteomics;Protocols documentation;Publishing;Regulation;Repression;Research;Ribosomes;RiboTag;RNA;RNA Binding;RNA-Binding Proteins;Role;Spermatocytes;Spermatogenesis;Testing;Testis;Thick;Time;tool;Transcript;transcriptome sequencing;Translational Regulation;Translational Repression;Translations;translatome;Work

PROJECT_TITLE: Novel mechanisms regulating translation elongation during male germ cell differentiation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Digestive Diseases;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Nanotechnology;Nutrition;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The proposed research is relevant to public health as these studies will generate new fundamental knowledge in vaccinology, address current technical limitations in vaccine technologies.

PI_NAMEs: LEI, YU LEO;MOON, JAMES J. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Adjuvant;Affect;Antigen Presentation;Antigen-Presenting Cells;Antigens;Benchmarking;Biocompatible Materials;biomaterial interface;Biomedical Engineering;cancer immunotherapy;Cancer Vaccines;CD8-Positive T-Lymphocytes;cell killing;Cells;Cichorium intybus;Colon;Combination immunotherapy;commensal microbes;Consumption;craniofacial;cytotoxic;delivery vehicle;Dental;design;Dietary Fiber;Disease;Distant;Drug Delivery Systems;effector T cell;Engineering;exhaustion;Formulation;Genetically Engineered Mouse;Goals;gut microbiome;gut microbiota;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;High Density Lipoproteins;HLA-A2 Antigen;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologic Memory;Immunologic Stimulation;Immunological Models;immunomodulatory strategy;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Incidence;Infiltration;innovative technologies;Inulin;Knowledge;lymph nodes;Lymphatic;Modeling;Mus;nanodisk;nanoparticle;nanovaccine;National Institute of Dental and Craniofacial Research;neoplastic cell;new technology;novel strategies;novel vaccines;Oral;oral HPV;oral HPV-positive head and neck cancers;Patients;Phenotype;prebiotics;programmed cell death ligand 1;programmed cell death protein 1;prototype;Public Health;Research;Resistance;Role;Route;Serum;Structure;success;System;T cell infiltration;T cell response;T-Lymphocyte;Technology;tool;Toxic effect;tumor;uptake;vaccine delivery;Vaccines;vaccinology

PROJECT_TITLE: New Engineering Strategy for Harnessing Immune System against Head and Neck Cancer

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Infection with Shigella spp. resistant to first and second-line WHO recommended antibacterial treatments is rapidly increasing worldwide, and there is an urgent need for new therapeutic options. However, it still is not clear what pharmacokinetic parameters are associated with efficacy or emergence of resistance for any shigellosis treatment. Our proposed studies aim to determine antibacterial pharmacokinetic properties that contribute to their in vivo efficacy and emergence of resistance.

PI_NAMEs: ARNOLD, SAMUEL L (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acceleration;Acute;Africa;Animal Experiments;Anti-Bacterial Agents;Area;Asia;Azithromycin;Bacterial Drug Resistance;bile salts;burden of illness;Cefixime;Cell Line;Cessation of life;Characteristics;Child;Ciprofloxacin;Clinic;Clinical;Colon;Communicable Diseases;Communities;Country;Cryptosporidiosis;Cryptosporidium;Data;design;Development;Diarrhea;diarrheal disease;Dose;Dose Fractionation;drug development;drug discovery;Drug Exposure;Drug Kinetics;Drug resistance;Dysentery;Enteral;enteric infection;enteric pathogen;Environment;Fatty Acids;Fiber;Foundations;Future;gastrointestinal;Gastrointestinal Agents;Gastrointestinal tract structure;Goals;Growth;Human;improved;In Vitro;in vivo;in vivo Model;indexing;Infection;innovation;Invaded;Knowledge;Large Intestine;Link;mass spectrometric imaging;men who have sex with men;Methods;Modeling;mortality;mouse model;Multicenter Studies;Mus;new chemical entity;novel therapeutics;Oral Administration;pathogen;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Physiological;physiologically based pharmacokinetics;Plasma;Population Attributable Risks;pre-clinical;preclinical development;Prevalence;Property;Rationalization;Recommendation;Reducing Agents;Regimen;Reporting;Research;Resistance;Resistance development;resistant strain;Resource-limited setting;Resources;response;Series;Shigella;Shigella Infections;Site;Symptoms;Therapeutic;Therapeutic Effect;Time;tool;Toxic effect;Virulence;Work

PROJECT_TITLE: Pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative This project is relevant to public health because it addresses a novel mechanism increasing progression of clonal hematopoiesis a common event in older individuals may lead to increased morbidity and risk of bone marrow failure and malignancy. If successful, it will provide a scientific basis for development of new strategies to prevent and/or treat these pathologies. It is also expected to advance the field of aging biology by elucidating how clonal hematopoiesis causes inflammation. This is highly relevant to the NIH mission of developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: CALVI, LAURA M (contact);LIESVELD, JANE L.

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;age effect;age related;age related changes;aged;Aging;aging biomarker;aging mechanism;aging related;Area;Biology of Aging;bone aging;Bone Marrow;Bone marrow failure;cardiovascular risk factor;Cell Aging;Cell model;Cells;Chronic;Clinical;clinical development;Clonal Expansion;Data;defined contribution;derepression;Development;disability;DNA Repair;DNMT3a;Dysmyelopoietic Syndromes;Elderly;Epigenetic Process;epigenome;Event;experimental study;extend lifespan;Failure;Functional disorder;Gene Frequency;Genes;genetic element;genetic variant;Genome;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Heterogeneity;high risk;HIV;Homeostasis;Human;improved;Individual;Infection;Inflammation;Inflammatory;interest;Interleukin-1 beta;Intervention;Knowledge;Lesion;leukemia;life span;loss of function;Macrophage;Malignant Neoplasms;Marrow;middle age;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;Natural Immunity;novel;Nucleotides;old mice;Older Population;Organism;overexpression;Oxidoreductase;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;Preleukemia;prevent;Process;progression risk;Public Health;Recording of previous events;Regulation;Reporting;Repression;Research;Resolution;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Reverse Transcription;Risk;risk prediction;RNA;Role;senescence;sex;Sirtuins;Stromal Cells;Testing;Time;Translations;Transplantation;United States National Institutes of Health;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Telehealth

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Mobile app mental health interventions are accessible and effective when used at the recommended dose; but when implemented in routine care, patients do not stay engaged long enough to see clinical benefits. The proposed research evaluates what drives patient engagement and tests the impact of two strategies— automated motivational push messaging and coach support—to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety. Findings will lay the foundation for a program of research focused on optimizing mobile app interventions for engagement and effectiveness.

PI_NAMEs: LIPSCHITZ, JESSICA MORROW (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adoption;Anxiety;Area;arm;Attitude;Automobile Driving;behavior change;behavioral construct;Cellular Phone;Characteristics;Clinic Visits;Clinical;Clinical Data;Clinical effectiveness;clinical implementation;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;comorbidity;Computers;cost;Cost of Illness;Costs and Benefits;Cues;Data;Data Science;design;digital mental health;digital models;Disease;Distress;Dose;effective therapy;Effectiveness;Evaluation;evidence base;experience;Feedback;field study;Foundations;Future;Goals;Grant;Habits;Human;implementation intervention;improved;innovation;Internet;Intervention;Intervention Studies;Interview;Investigational Therapies;Light;Literature;Measures;meetings;Mental Depression;Mental Health;Methods;mobile application;Modeling;Motivation;Notification;novel;Outcome;Outcome Measure;Participant;patient engagement;Patient Self-Report;Patients;Population;primary care patient;programs;Protocols documentation;prototype;Provider;psychosocial;Psychotherapy;Public Health;Qualifying;Randomized;Recommendation;recruit;Research;Research Personnel;routine care;Scientist;Self Efficacy;Series;Social Facilitation;social influence;social stigma;System;Technology;Testing;theories;Time;Touch sensation;Training;Transportation;treatment adherence;trial design;user centered design

PROJECT_TITLE: Toward optimizing digital mental health interventions: A clinical trial aimed at understanding what drives patient engagement.

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Mechanisms of RGC and axonal degeneration in diabetic retinopathy (DR) is largely unknown. Our proposed studies will identify novel roles of Sirt6 and DDR-ATM pathway in retinal neurodegeneration in DR and establish a link between them. Knowledge learned from this project may identify novel strategies to limit RGC and axonal injury and preserve vision in DR.

PI_NAMEs: ZHANG, WENBO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Abbreviations;Adult;Age;age acceleration;age related;Aging;aging mechanism;aging process;Animal Model;anti aging;ataxia telangiectasia mutated protein;ATM Signaling Pathway;Axon;axon injury;axonal degeneration;beta-Galactosidase;Biochemistry;Blindness;blood glucose regulation;Blood Vessels;Brain;Cardiovascular system;Cell Aging;Cell Death;Cell division;cell injury;cell type;Cessation of life;Chronic;Clinic;Clinical;clinically significant;conditional knockout;Data;Deacetylase;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;DNA Damage;DNA Repair;Electroretinography;Endothelial Cells;Exhibits;Extravasation;Family;Functional disorder;Gamma-H2AX;Ganglion Cell Layer;gene repression;Genes;Genomic Instability;Glucose;Histone Deacetylase;Histone H3;Homologous Gene;Immunohistochemistry;Inflammation;Injury;Inner Nuclear Layer;Kidney;knock-down;Knock-out;Knowledge;Learning;life span;Link;Lysine;Mammals;Mediating;member;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;neovascularization;Nerve Degeneration;Neuronal Injury;Neurons;neuroprotection;Nicotinamide adenine dinucleotide;nitrosative stress;non-invasive imaging;novel;novel strategies;Nuclear;Optic Nerve;Optical Coherence Tomography;overexpression;Oxidative Stress;Pathologic;pathological aging;Pathology;Pathway interactions;Patients;Phenotype;Play;Positioning Attribute;premature;Premature aging syndrome;preservation;prevent;Process;Proteins;Reperfusion Therapy;Reporting;response;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal ischemia;retinal neuron;Role;senescence;senescence associated secretory phenotype;senescent cell;Sirtuins;Stains;Stimulus;Streptozocin;Stress;Synapsins;Testing;transcription factor;Vision;Visual evoked cortical potential;Visual impairment;Yeasts

PROJECT_TITLE: Anti-Aging Molecule Sirt6 in Neuroprotection in Diabetic Retina

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The number of deaths due to opioid overdose continue to increase each year and rates are rising faster for Black people than for any other racial/ethnic group. Interventions are critically needed that can effectively reduce overdose mortality and do so equitably for Black people. The results of this study will quantify the effectiveness of policy interventions for the opioid crisis and identify the sets of provisions that best reduce overdose mortality overall and specifically among Black people.

PI_NAMEs: PAMPLIN, JOHN RICHARD (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;attributable mortality;Behavior;Biometry;Black Populations;Black race;career;career development;Cessation of life;Computing Methodologies;contextual factors;County;COVID-19 pandemic;Data;data framework;Data Set;Data Sources;Death Rate;Development;Development Plans;Disparity;Drug user;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Epidemiology;Equity;Ethnic Population;experience;Fatality rate;Foundations;Harm Reduction;help-seeking behavior;Individual;innovation;Intervention;Knowledge;Law Enforcement;Laws;Literature;Machine Learning;machine learning method;Measurement;Measures;Mentorship;Methodology;Methods;mortality;multidimensional data;multidisciplinary;Naloxone;Neighborhoods;novel;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid policy;opioid user;Overdose;overdose death;overdose prevention;Overdose reduction;Overdose reversal;Pattern;Persons;Pharmaceutical Preparations;Policies;Policy Analysis;prescription drug abuse;Psychiatric epidemiology;Public Health;Questionnaires;Race;racial disparity;racial diversity;racial population;Recovery;recruit;Reporting;Research;Research Personnel;Resources;response;Role;Services;Site;skills;Statistical Methods;substance use;synthetic opioid;System;Taxonomy;Training;treatment effect;United States;United States National Center for Health Statistics;Vital Statistics

PROJECT_TITLE: Racial Inequities in Opioid Overdose Prevention: The role of local context in the effectiveness of state-level overdose prevention policies

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Student Opportunities for AIDS/HIV Research (SOAR) is a multi-component theory-based two-year long research education mentoring program for University of Michigan undergraduate students from NIH-designated groups that are underrepresented in the biomedical, clinical, behavioral and social sciences (URM: NOT-OD- 20-031). Given the program's thematic focus on HIV-centered behavioral and social science research priorities within sexual and gender minority (SGM) communities, we will also encourage participation from URM students who identify as SGM (NOT-OD-19-139). SOAR is grounded in the expanded Social Cognitive Career Theory; patterned after the evidence-based U.S. Department of Education funded Ronald E. McNair Post- baccalaureate Achievement Program; incorporates elements of the evidence-based research mentoring program Entering Mentoring and the evidence-based research mentee program Entering Research; and allows for two years of intensive faculty-mentored research experiences for undergraduate students interested in pursuing doctoral education leading to a research career in the mental health of HIV/AIDS.

PI_NAMEs: HARPER, GARY W (contact);KIRKLAND, ANNA RUTHERFORD

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Admission activity;Affect;AIDS prevention;Area;Arts;Award;Awareness;Bachelor's Degree;behavioral and social science;Behavioral Research;Biomedical Research;Bisexual;Black Populations;career;career development;Caring;Censuses;Clinical;Clinical Research;Cognitive;cohort;college;Communities;Community Participation;Complex;Continuity of Patient Care;Degree Completion;design;Discrimination;Diverse Workforce;Education;education research;Elements;Epidemic;evidence base;Evidence based program;Exclusion;experience;faculty mentor;faculty support;Foundations;Funding;Gays;Gender;gender minority community;gender minority group;Graduate Education;graduate school;graduate student;Grant;HIV;HIV/AIDS;Individual;innovation;Institution;Interdisciplinary Study;interest;Intervention;Knowledge;Latinx population;Literature;men;Mental Health;Mentors;Michigan;Midwestern United States;minority undergraduate;Names;National Institute of Mental Health;next generation;Pattern;peer coaching;Postbaccalaureate;programs;Public Health Schools;Research;Research Institute;Research Personnel;Research Priority;role model;School Nursing;Schools;Science;Sexual and Gender Minorities;skills;social;social science research;social stigma;Social Work;Societal Factors;Solid;Strategic Planning;Student recruitment;Students;success;Talents;Teacher Professional Development;theories;Training;transgender women;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;web site;Woman

PROJECT_TITLE: Pipeline to Graduate Education and Careers in Behavioral and Social Science Research for URM Undergraduates: Addressing HIV in Sexual and Gender Minority Communities


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging;Brain Disorders;Mental Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE This Research Fellowship has prepared many generations of physicians and Ph.D. scientists for a successful research career in geriatric mood disorders over 30 years. We have transformed our training in response to changes in science, the National Academy of Medicine mandates, the 2020 NIMH Strategic Plan Draft, the RDoC Project, and the evolution of our research team. We request to extend the fellowship for another 5 years, as we believe that our future ability to reduce the burden of mid- and late-life mood disorders rests on the development of tomorrow's science leaders.

PI_NAMEs: GUNNING, FAITH M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Research Fellowship in Geriatric Mood Disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Cerebral glucose hypometabolism is now considered one of the hallmarks of Alzheimer’s disease (AD), clinical AD symptoms almost never occur in the absence glucose hypometabolism, and the extent of the metabolic changes measured strongly correlate with the severity of clinical symptoms. The mechanism(s) that drive glucose hypometabolism remain a critical knowledge gap in AD research. This proposal aims to examine age- related changed in cerebral glucose metabolism in both healthy and AD mouse models to 1) improve our understanding in the metabolic aging process and 2) to identify divergent events that result in the onset of AD from the aging population.

PI_NAMEs: SUN, RAMON C. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;AD transgenic mice;Age;age related;age related changes;Aging;aging brain;aging demography;aging population;aging process;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;amyloid pathology;Anabolism;Antibodies;apolipoprotein E-4;Architecture;Astrocytes;Autopsy;Behavior;Binding;Biochemical;Brain;brain metabolism;Carbon;Cerebrum;Characteristics;Clinical;Cognition;Data;design;Disease Progression;efficacy evaluation;enzyme therapy;Enzymes;Event;Glucose;glucose metabolism;Glycogen;glycogen metabolism;Glycogen Storage Disease;hallmarks of aging;Human;Impairment;improved;In Vitro;in vitro Model;in vivo;Incidence;Individual;Kentucky;Knowledge;Lead;Learning;Mass Spectrum Analysis;Measures;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Molecular;mouse model;multidisciplinary;Mus;mutant;Nerve Degeneration;Neurons;neuropathology;novel;novel therapeutics;Onset of illness;Pathogenesis;Pathologic;Patients;Play;Polysaccharides;Positioning Attribute;pre-clinical;Premature aging syndrome;Process;Reporting;Research;Research Personnel;Resolution;Rodent;Role;Sampling;Severities;skills;Specimen;stable isotope;Staging;Symptoms;System;Tauopathies;Techniques;Testing;Therapeutic;therapeutic target;Universities

PROJECT_TITLE: Aberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Obstructive Pulmonary Disease;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Tuberculosis, the leading infectious killer worldwide, is associated with lung injury which can persist despite successful therapy. This persistent lung injury is an important contributor to excess morbidity and mortality in treated tuberculosis. In this study, we will characterize the phenotype, progression and immune correlates of post-tuberculosis chronic lung disease to inform future preventive and therapeutic strategies.

PI_NAMEs: GUPTE, AKSHAY NITIN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acute Lung Injury;Address;Adult;Affect;airway obstruction;Award;Bronchodilator Agents;Cessation of life;Chronic;Chronic lung disease;Chronic Lung Injury;Chronic Obstructive Pulmonary Disease;Clinical Research;clinically relevant;cohort;Complement;Complex;Cross-Sectional Studies;Data;Data Reporting;detector;Diagnostic;Disease;Disease Progression;Evaluation;follow-up;Forced expiratory volume function;functional outcomes;Future;High Prevalence;Image;imaging study;Immune;immune activation;Immune Targeting;Immunologic Markers;Immunologics;immunoregulation;Impairment;India;Infectious Disease Epidemiology;Infectious Diseases Research;Infectious Lung Disorder;Inflammation;Inflammatory;inflammatory marker;Intervention;Knowledge;Link;Lung;Lung Diseases;lung imaging;lung injury;Measurement;Measures;Mentorship;Monitor;Morbidity - disease rate;Morphology;mortality;Natural History;never smoking;novel;Outcome;Oxidative Stress;Participant;Pathway interactions;Patients;Pattern;Phase;Phenotype;Plasma;prevent;Preventive;Process;profibrotic cytokine;Prognosis;prognostic;prospective;Prospective, cohort study;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Inflammation;Pulmonary Tuberculosis;recruit;Relapse;Reporting;Research;Research Personnel;Risk Factors;Role;Secondary to;Severities;Site;Smoking;smoking exposure;Smoking Status;Spirometry;Sputum;Statistical Methods;Structure of parenchyma of lung;targeted treatment;Testing;Therapeutic;Therapeutic Trials;Tissues;Training;Tuberculosis;tuberculosis treatment;Vital capacity;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Phenotype, Progression and Immune Correlates of Post-Tuberculosis Lung Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project narrative Numerous human diseases and syndromes are caused by disturbances in gene expression, and an important component in this process is the ability of cells to complete the production of mRNAs from the genome. The goal of the work described in this proposal is to understand how a multifunctional protein complexes balances gene expression during stress. The complex that is the focus of this proposal have been implicated in DNA damage resistance, cell proliferation and cardiovascular development; thus, the work described here is directly relevant to human health.!

PI_NAMEs: REESE, JOSEPH C (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemistry;biological adaptation to stress;Buffers;Cardiovascular system;Cell Proliferation;Cells;Complex;Development;Disparate;DNA Damage;DNA Repair;Equilibrium;Eukaryota;flexibility;Gene Expression;Gene Modified;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Genomics;Goals;Health;Human;human disease;Laboratories;Lead;Maps;Messenger RNA;Modification;Molecular;Molecular Biology;Molecular Genetics;mRNA Decay;novel;Oxidative Stress;Oxidative Stress Induction;Process;Production;programs;protein complex;Proteins;Proteomics;reconstitution;Research;Resistance;response;Rest;RNA Polymerase II;Role;Site;Stimulus;Stress;Syndrome;Translational Repression;Ubiquitin;virtual;willingness;Work;Yeasts

PROJECT_TITLE: Activities of yeast Ccr4-Not transcription factor complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Many rural hospitals are in financial distress and face challenges that contribute to poor access to care and poor health outcomes for cancer patients living in rural areas. This project will assess the impact of an innovative state program, which changes the way rural hospitals are paid and encourages new approaches to health care delivery, on surgery for rural cancer patients. Results will provide timely evidence about strategies to address the needs of surgical cancer patients in rural communities throughout the United States.

PI_NAMEs: SABIK, LINDSAY MARIE (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Accounting;Address;Affect;Age;Area;barrier to care;Budgets;cancer care;cancer health disparity;Cancer Patient;cancer surgery;care delivery;care outcomes;Caring;Characteristics;Communities;Complex;Data;data registry;design;Disparity;econometrics;experience;experimental study;Face;Financial Hardship;financial incentive;Focus Groups;geographic disparity;Goals;Health;health care availability;health care delivery;Health Personnel;Health Services Accessibility;Healthcare;Heterogeneity;Hospital Administrators;hospital care;hospital readmission;Hospital Restructuring;Hospitals;implementation process;implementation science;Improve Access;improved;improved outcome;Incentives;Incidence;informant;innovation;Interview;Link;Location;Malignant Neoplasms;Marketing;medical specialties;Methods;Modeling;mortality;National Cancer Institute;neoplasm registry;novel strategies;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Pattern;payment;Pennsylvania;Phase;Policies;poor health outcome;Population;population health;Process;programs;Provider;Qualitative Evaluations;Qualitative Methods;Quality of Care;Recommendation;Records;Regional Cancer;Resources;response;Risk;Rural;rural area;Rural Community;rural disparities;Rural Health;rural healthcare;Rural Hospitals;rural patients;rural residence;Services;Site Visit;Specialized Center;Stream;Surgeon;surgery outcome;Surgical Oncology;targeted delivery;Time;tumor;United States;United States Centers for Medicare and Medicaid Services;urban area;Variant

PROJECT_TITLE: Impact of Rural Hospital Payment and Delivery Reform on Geographic Disparities in Cancer Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(02)]


ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative During aging, skeleton undergoes deterioration and becomes more susceptible for development autoimmune disease including rheumatoid arthritis. Sialic acid level in serum and sialylation of cellular receptors continuously increase during aging implicates pathogenesis of skeleton aging and autoimmune disease. The objective of the proposed study is to develop a therapeutic treatment using a sialylation inhibitor Soyasaponin Bb for rheumatoid arthritis.

PI_NAMEs: CAO, XU  (contact)

PROJECT_TERMS: Adult;Age;age acceleration;aged;Aging;aging population;Arthralgia;Autoantibodies;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Binding;bone;Bone Diseases;bone loss;bone mass;Bone Resorption;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell fusion;Cells;Collagen Arthritis;cytokine;Degenerative polyarthritis;Deterioration;Development;Disease;Equilibrium;Excision;Family;Gene Expression Profile;Generations;Genetic Transcription;glycosylation;Immunoglobulins;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Interferon Type II;Interleukin-10;JAK2 gene;joint destruction;Ligands;Macrophage;Macrophage Colony-Stimulating Factor;Marrow;Mass Spectrum Analysis;Measures;member;Modeling;monocyte;Mononuclear;Multiple Sclerosis;Mus;Neuraminidase;Nuclear;old mice;osteoclastogenesis;Osteoclasts;Pathogenesis;Pathway interactions;Population;Predisposition;Process;Proliferating;Proteins;RANK protein;receptor;Regulatory T-Lymphocyte;Rheumatoid Arthritis;Saponins;Serum;sialic acid binding Ig-like lectin;sialic acid-binding lectin;Sialic Acids;sialylation;Sialyltransferases;Signal Transduction;Site;Skeleton;soy;Soyasaponin;subchondral bone;Systemic Lupus Erythematosus;T-Lymphocyte;Terpenes;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;TNF gene;Transgenic Organisms

PROJECT_TITLE: Sialylation of TLR2 Induces Osteoclast Fusion and Th 17 differentiation During Aging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Cost Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: DAR ES SALAAM

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS

PHR: Project Narrative We propose to show that many adolescent schoolchildren with the early stage of new TB infection have a previously undetected case of active TB disease in their household, a finding that would fundamentally change the understanding of TB transmission to adolescents. Very importantly this finding would lead to an innovative new public health method to identify previously undetected cases of TB disease, a major goal of the global plan to eliminate tuberculosis.

PI_NAMEs: AMOUR, MARYAM  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 15 year old;active method;Adolescent;Adopted;Adoption;Africa South of the Sahara;Agreement;Ally;Biological Assay;case finding;Cause of Death;Cessation of life;Child;Collaborations;Communicable Diseases;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Country;Detection;Developed Countries;Development;Diagnosis;Disease;Ensure;Epidemiologist;epidemiology study;experience;feasibility testing;global health;Goals;Health;health goals;Health Policy;Household;improved;Incidence;Infection;infection rate;innovation;Interferon Type II;Leprosy;low and middle-income countries;low income country;medical schools;Methods;Monitor;Newly Diagnosed;Notification;Outcome;Participant;Patients;Persons;point of care;Population;programs;Public Health;Recommendation;Relapse;Reporting;Research;research study;Schools;Science;Source;Tanzania;Testing;transmission process;treatment guidelines;Tuberculosis;Universities;World Health Organization

PROJECT_TITLE: A new method for active tuberculosis case finding

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Non-traumatic subarachnoid hemorrhage, bleeding into the subarachnoid space around the brain from the rupture of an aneurysm, is a potentially devastating and often deadly subtype of stroke. There is a great need for ways to accurately identify and treat patients most at risk for neurologic deterioration from complications like cerebral vasospasm or delayed cerebral ischemia. Adequate blood pressure management tailored to individual patients, aiming to maintain optimal brain blood flow and function, may prevent additional brain injury and is an important first step towards personalized medicine for patients suffering from subarachnoid hemorrhage.

PI_NAMEs: KIM, JENNIFER A;MATOUK, CHARLES  (contact);PETERSEN, NILS H.

PROJECT_TERMS: Acute;Adult;Affect;Aneurysmal Subarachnoid Hemorrhages;Benchmarking;Biological Markers;biomarker driven;Blood Pressure;blood pressure control;Blood Vessels;Brain;Brain hemorrhage;Brain Injuries;Caring;cerebral autoregulation;Cerebral hemisphere hemorrhage;cerebral hemodynamics;cerebral hypoperfusion;Cerebral Ischemia;Cerebral perfusion pressure;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular Spasm;Cerebrum;Clinical;clinical center;clinical investigation;clinical practice;Clinical Trials;cohort;Cohort Studies;Compensation;Complication;Coupled;Critical Illness;Data;data repository;Detection;Deterioration;Development;diagnostic strategy;disability;Disabled Persons;Disease;Distress;Early Diagnosis;Early Intervention;Electroencephalography;epileptiform;exhaust;Exogenous Factors;Failure;Fright;Functional disorder;functional improvement;functional outcomes;Future;Goals;Hemorrhage;high risk;Homeostasis;hypoperfusion;improved;Individual;individual patient;Informatics;Infrastructure;innovation;insight;Intervention;Intracranial Pressure;Ischemia;Ischemic Stroke;Knowledge;Link;Metabolic;Metabolism;Mission;Modeling;Monitor;Morbidity - disease rate;Nature;Near-Infrared Spectroscopy;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurologic Deficit;Neurology;Neurons;neurophysiology;neuroprotection;neurovascular;novel;Operative Surgical Procedures;Outcome;Patients;Pattern;Perfusion;personalized approach;personalized medicine;pharmacologic;Phase;Phenotype;Physiological;Physiology;Play;population based;precision medicine;pressure;prevent;Principal Investigator;prospective;Protocols documentation;Quality of life;Recovery;Research;Research Proposals;Resources;Rest;Risk;Risk Assessment;risk mitigation;Ruptured Aneurysm;Sedation procedure;signal processing;Signal Transduction;Stroke;Subarachnoid Hemorrhage;Subarachnoid Space;Survivors;Technology;Testing;Therapeutic;Time;tissue oxygenation;tool;Transcranial Doppler Ultrasonography;treatment strategy;United States;United States National Institutes of Health;Vasospasm

PROJECT_TITLE: Electroencephalographic signatures of dysfunctional cerebrovascular autoregulation as biomarkers of brain injury in aneurysmal subarachnoid hemorrhage (SAH)


ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The long-term health of kidney transplant patients in the United States depends critically on the immunosuppressive drugs that are taken by such patients long-term during the duration of their transplant function. This project aims to improve the safety and efficacy of these immunosuppressive strategies by modeling new strategies in a closely related non-human primate (NHP) species, rhesus monkey, that share 97% genetic identity with humans. Lessons learned from our previous and ongoing work from our prior U19 NIH award is already being translated into human clinical trials, and we anticipate further advances to move into clinical trials to help further prolong kidney transplant function and patient survival, thus extending the lifespan and quality of life of patients with kidney failure.

PI_NAMEs: KNECHTLE, STUART JOHNSTON (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: Acceleration;Address;Affect;Alloantigen;allotransplant;Animal Model;Antibodies;antibody-mediated rejection;Antithymoglobulin;Award;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;Biology;Cardiovascular Diseases;career;Cause of Death;Cessation of life;Chronic;Clinical Trials;Collaborations;Cytomegalovirus Infections;Data;Drug Combinations;End stage renal failure;Evaluation;experience;extend lifespan;Funding;Future;Genetic;Genetic Identity;Goals;Grant;Health;Helper-Inducer T-Lymphocyte;Human;IL2 gene;Immune;Immune response;Immune Tolerance;immunological intervention;Immunology;Immunosuppression;Immunosuppressive Agents;improved;Individual;Indolent;Industry Collaboration;Infection;Infusion procedures;insight;isoimmunity;Kidney Failure;Kidney Transplantation;Letters;lymph nodes;Macaca;Macaca mulatta;Malignant Neoplasms;Measures;Mediating;Memory B-Lymphocyte;Methodology;Modeling;National Institute of Allergy and Infectious Disease;nonhuman primate;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Organ Transplantation;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Population;prevent;Publishing;Quality of life;Regulation;Regulatory T-Lymphocyte;Research;response;Risk;Safety;Sirolimus;Structure of germinal center of lymph node;T-Lymphocyte;Therapeutic immunosuppression;tool;Training;Translating;transplant model;Transplant Recipients;Transplantation;transplantation medicine;United States;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: The Risks and Opportunities of Homeostatic Repopulation


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

PI_NAMEs: BARBAS, ANDREW SERGHIOS (contact)

PROJECT_TERMS: Adherence;Allografting;allotransplant;biomarker validation;Clinical;Collaborations;Communication;Complement;Complex;cooperative study;design;Development;Ensure;Goals;Graft Rejection;Grant;Heart Transplantation;Immune Tolerance;improved;Islets of Langerhans Transplantation;Kidney Transplantation;Logistics;Lung Transplantation;Maintenance;member;Mission;Modeling;nonhuman primate;novel;Population;preclinical efficacy;preclinical evaluation;preclinical safety;Productivity;programs;Regimen;Regulation;Research;Research Personnel;Resources;Risk;Structure;success;Transplantation;Transplantation Tolerance;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


PI_NAMEs: KIRK, ALLAN D. (contact)

PROJECT_TERMS: Adaptive Immune System;anergy;Antigens;Archives;Autopsy;B-Lymphocytes;biobank;Biological;Biological Assay;Biopsy;Cell Count;cell type;Cells;Characteristics;Charge;chemokine;Clinical;clinically relevant;Clonal Deletion;Clone Cells;Collaborations;Color;Communicable Diseases;Communities;Computational Biology;Computer Analysis;Core Facility;Cryopreservation;cytokine;Cytomegalovirus;Data;Data Analyses;Data Analytics;Data Set;density;Dimensions;Elements;Environment;Environmental Exposure;Equipment;exhaustion;experience;experimental study;Flow Cytometry;forging;Funding;Future;Genetic Polymorphism;Genetic Transcription;Growth;Histologic;Histology;Human;Human Herpesvirus 4;Immune;Immune response;Immunoassay;Immunobiology;Immunocompromised Host;Immunohistochemistry;Immunology;Immunology procedure;imprint;in vivo evaluation;Individual;Infrastructure;Infusion procedures;Injury;insight;International;Laboratories;large datasets;Leadership;Lived experience;lymph nodes;Lymphocryptovirus;Lymphocyte;Macaca mulatta;Management Information Systems;Maps;Measurement;Methods;Monitor;monocyte;multidimensional data;nonhuman primate;novel;Organ;Organ Transplantation;Outcome;pathogenic virus;Peripheral;Peripheral Blood Mononuclear Cell;pharmacologic;Phenotype;Plasma;Plasma Cells;Population;Preparation;Primates;Procedures;programs;recruit;Research;Research Personnel;research study;Research Support;resilience;response;Rhesus;Risk;RNA;RNA Sequence Analysis;Sampling;Scientist;sequencing platform;Serum;Services;Simian virus 40;single-cell RNA sequencing;Specimen;Specimen Handling;Stains;Standardization;Stress;Supervision;Technical Expertise;Testing;testing services;Therapeutic;Thymus Gland;Tissue Grafts;Tissue Sample;Tissues;Transplant-Related Disorder;Transplantation;Universities;Veterinary Medicine;Viral;Virus;virus testing;Work

PROJECT_TITLE: Computational Immunobiology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE In this study, we develop and use state-of-the-art proteomics to characterize Tau, its modifications and the modification-causing enzymes in primary post mortem brain tissue samples from patients with varying stages of Alzheimer's disease (AD). Large datasets from primary human tissue provides target prioritization information for functional follow-up experiments to identify which Tau modifications and the modification-causing enzymes in AD that lead to disease progression. The aim of this work is to identify therapeutic strategies for AD in early stages of disease.

PI_NAMEs: STEEN, JUDITH A (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amygdaloid structure;angular gyrus;Autopsy;Biochemistry;Bioinformatics;Biological Assay;Biological Models;Brain;Brain region;brain tissue;Cells;Clinical;Clinical Data;cohort;Competence;Consensus Sequence;Data;Data Set;Dependence;Development;Disease;Disease Progression;enzyme activity;Enzymes;Exhibits;experimental study;follow-up;frontal lobe;Goals;Human;human disease;human subject;human tissue;Impaired cognition;In Vitro;in vivo;Inferior;Intervention;large datasets;Learning;life span;Maps;Mass Spectrum Analysis;Methodology;Methods;Modification;Molecular;Nature;Nerve Degeneration;neurofibrillary tangle formation;Neurofibrillary Tangles;novel;Pathologic;Pathology;Patients;Pattern;Phenotype;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;prion-like;Protein Isoforms;Proteins;Proteome;Proteomics;sensor;Signal Pathway;Signaling Protein;Site;Specimen;tau aggregation;tau Proteins;tau-1;Temporal Lobe;Testing;Therapeutic;Tissue Sample;Tissues;Toxic effect;Validation;Visual Cortex;Work

PROJECT_TITLE: Integrated Platform to study Neurodegeneration in Alzheimer’s Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Kidney Disease;Organ Transplantation;Prevention;Transplantation;Vaccine Related

PHR: PROJECT NARRATIVE – Project 2 Building on knowledge gained during our previous NHPCSG U19 award, this project aims to test clinically- feasible agents targeting post-transplant humoral response and determine efficacy of antigen-specific tolerance strategies for kidney transplantation in sensitized nonhuman primate recipients. It further aims to evaluate the protective and vaccine immune response after theseapproaches. Lastly, this project will determine the functional profile of allo-, viral- ,and vaccine-specific T and B cell required to establish donor-specific tolerance in sensitized recipients at repertoire levels using the cutting-edge technology of single cell immune repertoire sequencing to precisely identify molecular mechanisms of transplantation tolerance and its interaction with viral pathogens.

PI_NAMEs: KWUN, JEAN  (contact)

PROJECT_TERMS: Adjuvant Therapy;Alloantigen;Allogenic;Animals;Antibodies;antibody-mediated rejection;Antigen Presentation;Antigens;Apoptotic;Award;B cell repertoire;B cell therapy;B-Cell Activation;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Bone Marrow;Cell Culture Techniques;Cells;Clinical;Clinical Trials;Complement;cost comparison;Cytomegalovirus;desensitization;Dialysis procedure;Disease;Donor person;donor-specific antibody;efficacy evaluation;Elements;End stage renal failure;experience;Exposure to;Face;Female;Goals;Graft Survival;Health Care Costs;HLA Antigens;Immune;Immune response;Immune Tolerance;Immunity;Immunobiology;immunoregulation;Immunosuppression;improved;Infusion procedures;Kidney;Kidney Transplantation;Knowledge;Lymphocyte Depletion;Lymphoproliferative Disorders;Maintenance;Modeling;Molecular;Morbidity - disease rate;mortality;nonhuman primate;Outcome;parous;pathogenic virus;Pathway interactions;Patients;pharmacologic;Phenotype;plasma cell differentiation;Plasma Cells;Population;post-transplant;Pregnancy;preservation;prevent;Proteasome Inhibitor;Publishing;Quality of life;Regulation;response;Risk;Shapes;side effect;single cell technology;Structure of germinal center of lymph node;T memory cell;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;Time;Transfusion;Transplant Recipients;Transplantation;Transplantation Tolerance;vaccine immunogenicity;Vaccines;Viral;Virus Diseases;Waiting Lists

PROJECT_TITLE: Determinants of donor-specific B cell tolerance in kidney transplantation in sensitized recipients


NIH_SPENDING_CATS: Infectious Diseases;Lung;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis, a severe HIV-associated infection of the central nervous system. In healthy individuals, C. neoformans establishes latent infections that reactivate and cause clinical symptoms upon HIV-associated immunosuppression, yet disease manifestation differs across patients. Using a mouse model, this research will determine the continuum of patient immune responses and fungal genetic factors that influence clinical outcome towards the goal of developing novel immune-modulatory treatment strategies.

PI_NAMEs: NIELSEN, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Acute Disease;adaptive immune response;Address;AIDS-Related Opportunistic Infections;Alleles;Antigens;Biology;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Central Nervous System Infections;Characteristics;Chimera organism;Classification;Clinical;cohort;comparative;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Data;Death Rate;Desiccation;Disease;disease model;Disease Outcome;Disease Progression;disorder prevention;early childhood;Exhibits;experimental study;Exposure to;fungal genetics;fungus;Genes;genome analysis;genome wide association study;Goals;Granuloma;Growth;HIV;HIV/AIDS;Human;human disease;Immune;immune function;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunohistochemistry;Immunologics;immunomodulatory strategy;Immunosuppression;Impairment;Individual;Infection;Infection Control;Inflammatory Response;Inhalation;Innate Immune Response;Interferon Type II;latent infection;Lead;Life;logarithm;Lung;Lymphoid Cell;Mediating;Meningitis;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Myeloid Cells;Neurologic;novel;Observational Study;Outcome;pathogen;pathogenic fungus;patient population;Patients;Preventive treatment;Process;programs;Proteomics;pulmonary granuloma;Pulmonary Inflammation;recruit;Reporter;Reproduction spores;Research;response;Risk;single cell sequencing;Single Nucleotide Polymorphism;Symptoms;T-Lymphocyte Subsets;Testing;trait;translational study;treatment strategy;Virulence Factors;Yeasts

PROJECT_TITLE: Continuum of Immune Responses to Cryptococcus neoformans

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Wound Healing and Care

PHR: Narrative Dysregulated intestinal inflammation results in mucosal injury and impaired healing responses. Efficient repair of intestinal mucosa is dependent on complex events involving crosstalk between receptors on the epithelium as well as immune cells that are recruited to sites of injury. A better understanding of complex interplay between inflammatory cells and epithelial cells in orchestrating mucosal repair may provide ideas for druggable targets to promote healing during mucosal inflammation.

PI_NAMEs: PARKOS, CHARLES A (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Affinity;Agonist;antagonist;Binding;Biopsy;Bone Marrow;CD47 gene;Cell Communication;cell motility;cell type;Cells;Chimera organism;Colitis;Colon;Complex;Data;dextran sulfate sodium induced colitis;Disease;druggable target;Epithelial Cells;Epithelium;Event;first responder;Focal Adhesions;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;gut inflammation;healing;Health;Hematopoietic;Human;IL17 gene;Immune;Impaired healing;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;injured;Injury;injury and repair;Integrins;Interferon Type II;Interleukin-1 beta;intestinal epithelium;Intestinal Mucosa;Intestines;Kinetics;knock-down;Knockout Mice;Leukocytes;Leukotriene B4;Ligands;Ligation;lipid mediator;LTB4R gene;Mediating;Membrane Proteins;migration;Modeling;Mucositis;Mucous Membrane;Mus;Nature;neutrophil;novel;Production;receptor;Recovery;recruit;Regulation;repaired;Reporting;response;Role;Signal Transduction;Signaling Protein;Site;Thrombospondin 1;Thrombospondins;Tissues;TNF gene;TNFRSF1A gene;wound;wound healing

PROJECT_TITLE: Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Kidney Disease;Organ Transplantation;Transplantation

PHR: PROJECT NARRATIVE – Project 1 Strongly based on knowledge gained during ourpreviousNHPCSG U19 award, this project aims to test clinically- feasible tolerance strategies for both living and deceased donor kidney transplantation. It further aims to determine the host susceptibility and stability of tolerance in settings of unexpected post-transplant viral infections, abruptly brought into a sharp focus by the most recent SARS-CoV2 pandemic. Lastly, this project will employ the cutting-edge technology of single cell immune repertoire sequencing to precisely identify molecular mechanisms of transplantation tolerance and its interaction with viral pathogens.

PI_NAMEs: LUO, XUNRONG  (contact)

PROJECT_TERMS: anergy;Anti-Inflammatory Agents;Antigens;Antithymoglobulin;antiviral immunity;Award;B cell clonality;B-Lymphocytes;Bar Codes;Biological;Carbodiimides;Cell Therapy;Cells;Chemicals;Chronic;Clinical;Clonal Anergy;Clonal Deletion;Clonal Evolution;Clonality;combinatorial;COVID-19 pandemic;Crosslinker;Cytomegalovirus;Cytomegalovirus Infections;Data Analytics;dynamical evolution;efficacy evaluation;efficacy testing;Environment;first-in-human;Future;Ganciclovir;Gene Expression;Genes;Immune;Immune Tolerance;Immunity;Immunosuppression;Impairment;imprint;Infection;Infusion procedures;Injections;innovation;islet;islet allograft;Islets of Langerhans Transplantation;isoimmunity;Kidney;kidney allograft;Kidney Transplantation;Knowledge;Leukocytes;Living Donors;living kidney donor;Lymphocyte;Lymphoid Tissue;Macaca mulatta;Maintenance;Maps;Modeling;Molecular;mouse model;multidimensional data;Mus;Opportunistic Infections;Organ;Output;pathogen;pathogenic virus;Pattern;Phenotype;Population;Positioning Attribute;post-transplant;Predisposition;preservation;prophylactic;Regimen;Regulation;Reperfusion Injury;Resistance;Rhesus;Risk;Shapes;single cell technology;Sirolimus;Splenocyte;Sterility;T cell clonality;T-Lymphocyte;Technology;Testing;Therapeutic;Thymus Gland;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance;Vaccines;Vascularization;Viremia;Virus;Virus Diseases

PROJECT_TITLE: Determinants of donor-specific T cell tolerance in kidney transplantation in non-sensitized recipients


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Hypertension;Physical Activity;Prevention;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Hypertension affects 75% of older adults in the United States and current treatment options, inclusive of exercise training, are ineffective given only 21% of adults with hypertension have their blood pressure under control. We propose exercise training combined with chronotherapy will improve the effectiveness of this treatment option and plan to demonstrate this through a series of studies examining morning versus late afternoon/evening exercise on blood pressure and vascular health outcomes in older adults with hypertension. We expect this research will optimize exercise prescriptions for adults with hypertension which in turn will enhance their health and reduce the prevalence of hypertension.

PI_NAMEs: CURRIE, KATHARINE DIANNE (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acute;Adult;Aerobic;Affect;Age;age effect;Aging;Ambulatory Blood Pressure Monitoring;arterial stiffness;Blood Pressure;blood pressure control;blood pressure regulation;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chronic;Chronotherapy;Circadian Rhythms;Clinical Trials;combat;Combination Medication;Cross-Over Studies;Data;Disease;Disease Outcome;Diurnal Rhythm;Educational Intervention;Endothelium;Exercise;exercise intervention;exercise prescription;exercise training;Female;Future;Goals;Guidelines;Health;Health Status;Hypertension;hypertension control;hypertensive;Hypotension;improved;Individual;Intervention;Isometric Exercise;Life Style Modification;male;Medicine;Metabolic;Metabolism;modifiable risk;Nonpharmacologic Therapy;normotensive;novel;older adult;Older Population;Organ;Outcome;Outcome Assessment;Participant;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physical activity;Population;Postmenopause;Prevalence;Recommendation;Research;Research Design;response;Risk;Series;System;Time;Tissues;tool;Training;Treatment Effectiveness;treatment optimization;United States;Woman

PROJECT_TITLE: Chrono-exercise is Medicine: Improving Blood Pressure and Vascular Function through Chronotherapy

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Sensory hypersensitivity is a central issue in autism and autism-related disorders like Fragile X syndrome (FX), and relatively little is known about the underlying brain mechanisms. This proposal combines novel behavioral assays for assessing sound hypersensitivity in rodents with state-of-the-art electrophysiological, chemogenetic, and analytical techniques to determine the currently poorly understood nature of auditory perceptual and circuit abnormalities in FX. Results from this study will uncover fundamental neural disruptions at the core of FX and autism as well as provide a clinically translatable platform for screening potential therapies for auditory disturbances in these common and debilitating disorders.

PI_NAMEs: AUERBACH, BENJAMIN D (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Animals;Area;Auditory;Auditory area;Auditory Perception;Auditory system;autism spectrum disorder;autism symptoms;Automobile Driving;avoidance behavior;awake;Behavioral;Behavioral Assay;Behavioral Paradigm;behavioral phenotyping;Brain;Brain Pathology;Brain region;cell type;Cells;Chronic;Clinical;clinical translation;clinically relevant;Closure by clamp;Communication impairment;Complex;density;Disease;Electrodes;Electrophysiology (science);Equilibrium;Etiology;excitatory neuron;Exhibits;experience;Fragile X Syndrome;Functional disorder;Funding;gamma-Aminobutyric Acid;Genetic;genetic approach;Genetic Enhancement;genetic manipulation;Goals;Growth;hearing impairment;Hyperactivity;Hyperacusis;Hypersensitivity;Impairment;in vivo;Individual;Inherited;inhibitory neuron;insight;Interneurons;Ion Channel;Laboratories;Loudness;Loudness Perception;Measures;Mentors;model of autism spectrum disorder;Modeling;Nature;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;neuronal excitability;Neurons;neurophysiology;novel;patch clamp;Pathology;Perception;Population;Positioning Attribute;Postdoctoral Fellow;Preparation;Prevalence;Process;programs;Rattus;Research;response;Rodent;Role;screening;Sensory;Sensory impairment;Severities;Shapes;Slice;Social Interaction;sound;Symptoms;Synapses;synaptic function;System;Techniques;Testing;Thalamic structure;tool;Training;Viral;voltage clamp;Work

PROJECT_TITLE: Mechanisms of sound hypersensitivity in a rat model of autism

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research will investigate if exposure to greater neighborhood greenspace in early, mid, and late- life is associated with healthy brain aging as measured via regional brain volumes and longitudinal decline on multiple cognitive domains. The study will assess whether there are critical periods in which greenspace exposure may be most beneficial, as well as potential effect modification by sex, race, apolipoprotein E (genetic risk factor for Alzheimer’s disease), and geographic region. The ultimate goal is to provide evidence for community-level interventions that can increase cognitive resilience and healthy behaviors throughout the lifespan, promoting healthy brain aging and allowing older adults to age in place.

PI_NAMEs: BESSER, LILAH  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adherence;Affect;Age;Age Years;Aging;aging brain;aging in place;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Apolipoprotein E;Archives;Area;Attention;Behavior;Biological;Biology;Brain;brain health;Brain imaging;Brain region;brain volume;built environment;career;career development;cerebral atrophy;Cerebrovascular Disorders;Characteristics;Clinical;Cognition;Cognitive;cognitive neuroscience;cognitive reserve;community intervention;comorbidity;cost;Coupled;critical period;Data;Data Collection;Dementia;dementia risk;demographics;Deterioration;Development;Development Plans;Disease;early onset;Education;Educational process of instructing;Environment;Epidemiology;Episodic memory;Evaluation;executive function;Exposure to;Faculty;Financial Support;Florida;Funding;Genetic Risk;genetic risk factor;Genotype;Geographic Information Systems;Geographic Locations;Goals;good diet;Green space;Health;Health behavior;health data;health disparity;Health Planning;Health Professional;Health Promotion;healthy lifestyle;Hippocampus;human old age (65+);Imagery;Impaired cognition;improved;indexing;Individual;innovation;Institution;Interdisciplinary Study;Investigation;Knowledge;Language;late life;Learning;Life;life span;Life Style;Literature;Longitudinal, observational study;Measures;Memory;Mentors;middle age;mild cognitive impairment;Modeling;Modification;Motivation;multidisciplinary;National Institute on Aging;Neighborhoods;Neurology;novel;older adult;Outcome;Participant;Personal Satisfaction;Pharmacologic Substance;Physical activity;Play;Population;prevent;Privatization;programs;Public Health;Publishing;Questionnaires;Race;Recommendation;Research;Research Personnel;research study;Research Support;resilience;Risk Factors;Risk Reduction;Scientist;sex;sex variable;skills;Socioeconomic Status;stress reduction;supportive environment;Training;Universities;Urban Health;Vision;Walking;White Matter Hyperintensity

PROJECT_TITLE: Longitudinal associations between neighborhood greenspace and brain aging in cognitively normal older adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE We propose to develop and validate a novel sustainable, easy-to-use phenotypic drug susceptibility testing (DST) test for drug resistant tuberculosis (TB) using non-invasive specimens (i.e. sputum). We will focus on validating and confirming drugs recently approved by WHO to treat drug susceptible (RIPE and HPMZ drug regimens) and resistant (BPaL drug regimen) TB and confirm its efficacy against current phenotypic DST reference tests. This new DST test will be validated further in field settings (Democratic Republic of Congo and the US-Mexico border), where TB is a major health issue and is under-reported due to lack of widely available diagnosis.

PI_NAMEs: RESTREPO, BLANCA I;TORRELLES, JORDI B (contact);YOTEBIENG, MARCEL

PROJECT_TERMS: Acceleration;Agar;Agreement;Area;biobank;Blinded;Bovine Tuberculosis;Cause of Death;Chlorhexidine;Clinical;Collection;Color;Communicable Diseases;Communities;cost;Data;Decontaminant;Decontamination;Democratic Republic of the Congo;design;Diagnosis;Digestion;directed attention;Drug Costs;Drug Prescriptions;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Early Diagnosis;Epidemiology;Equipment;Ethambutol;Evaluation;Eye;field study;flexibility;Generations;Genotype;Goals;Growth;Health;improved;Income;individualized medicine;innovation;isoniazid;Laboratories;Linezolid;Liquid substance;low and middle-income countries;meetings;Methods;Mexican;Mexico;mortality;Moxifloxacin;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Notification;novel;novel therapeutics;Oral;Oral Tuberculosis;Patients;Pattern;Pharmaceutical Preparations;Phenotype;point of care;point of care testing;Power Sources;Predisposition;Process;Protocols documentation;Provider;Pyrazinamide;Recommendation;Regimen;Resistance;Resource-limited setting;Rifampin;rifapentine;sample collection;Sampling;Sensitivity and Specificity;Sodium Chloride;Solid;Specimen;Sputum;Surrogate Markers;Test Result;Testing;Thinness;Time;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;usability;World Health Organization

PROJECT_TITLE: Improving rapid phenotypic drug susceptibility testing for drug resistant tuberculosis in high-burden areas


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Based on a 35-year track record, reflected in our latest Medical Student Research Program followup, we anticipate cultivating a large number of diverse inquiring scientific physicians who understand and can contribute to the research enterprise (emphasizing cardiovascular, lung, and blood disorders, mechanisms, evaluation, and therapy), including a growing cadre of physician-scientist leaders to replenish the dwindling numbers of translational medical researchers. In this way, we will contribute to the concerted effort of NIH and NHLBI to build the diverse enlightened medical research teams of the future, to provide the latest in personalized care and precision medicine, and thereby to expedite the translation of scientific advances from “bench to bedside to diverse community”.

PI_NAMEs: WITTE, MARLYS HEARST (contact);ZHOU, WEI

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Arizona;Asthma;Attitude;Award;bench to bedside;Biology;Biomedical Engineering;Biomedical Research;Cardiac;Cardiovascular Diseases;cardiovascular prosthesis;Cardiovascular system;career;Cells;Clinical;clinical investigation;Clinical Medicine;clinical practice;Clinical Research;Communication;Community Medicine;Creativeness;Cystic Fibrosis;Databases;Development;Development Plans;Devices;Disease;Educational Curriculum;Educational workshop;Electrophysiology (science);Endothelium;Esapent;Evaluation;experience;Faculty;Failure;follow-up;forging;Fostering;Funding;Future;Genomics;Grant;Health;Heart failure;Hypertrophy;in silico;In Situ;In Vitro;in vivo;Individual;innovation;Institution;interest;International;Journals;Laboratories;Leadership;lymphology;Medical;Medical Students;Mentors;Microcirculation;Modeling;Molecular;multidisciplinary;Multimedia;Multimodal Imaging;National Heart, Lung, and Blood Institute;Online Systems;Organogenesis;Participant;Pharmaceutical Preparations;Physicians;population health;precision medicine;Productivity;professor;programs;Proteomics;Publications;Pulmonary Hypertension;Pulmonology;Reaction;Registries;Research;research and development;Research Personnel;Research Training;Resuscitation;role model;Science;Scientist;skills;Sleep Apnea Syndromes;Students;summer institute;Surveys;Thinking;Training;Training Programs;Translating;Translation Process;translational scientist;Translations;United States National Institutes of Health;Universities;Venous;virtual;Visit

PROJECT_TITLE: Short-Term Institutional Research Training Grant


NIH_SPENDING_CATS: Clinical Research;Genetics;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, and improved therapies for aGVHD are needed. To develop potential new targets for improving aGVHD, our group recently identified a novel T cell-enriched long noncoding RNA, LINC00402, that uniquely promotes allogeneic T-cell proliferation. We now seek to determine LINC00402’s function and molecular mechanism in both mice and humans.

PI_NAMEs: PELTIER, DANIEL C. (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Allogenic;Animal Model;Area;Binding;Bioinformatics;Biological Assay;Biology;career;career development;cell killing;Cell Nucleus;Cell Physiology;Cells;Clinical;cohort;Complication;curative treatments;cytokine;Cytoplasm;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Data Set;Development Plans;differential expression;disease model;Enhancers;Faculty;FOS gene;gastrointestinal;Gene Expression;Genetic Transcription;Goals;graft vs host disease;Grant;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Human;Immune response;Immunology;improved;In Vitro;in vivo;Interleukin-2;isoimmunity;Laboratories;Learning;Measures;Mediating;Mentors;Mentorship;Methods;Molecular;Molecular Genetics;mouse model;Mus;next generation sequencing;novel;Outcome;Patients;Physicians;Production;programs;Proteins;Receptor Signaling;Regulatory T-Lymphocyte;Research;Research Personnel;response;RNA;RNA Binding;RNA-Protein Interaction;Role;Sampling;Scientist;Signal Transduction;Specificity;System;T cell differentiation;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Th1 Cells;Tissues;Training;Training Programs;transcriptome sequencing;Transplantation Immunology;Untranslated RNA;Work;Writing

PROJECT_TITLE: Long noncoding RNA-mediated regulation of T-cell alloimmunity

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Persons with epilepsy often suffer from memory problems that may improve with a 6-week exercise program. We will investigate (1) the degree of memory improvement with exercise, (2) if the exercise program positively affects the brain regions involved in memory, and (3) whether the effects of exercise on memory and the brain can outlast the exercise program. This study would greatly impact our ability to treat memory problems in persons with epilepsy.

PI_NAMEs: ALLENDORFER, JANE B (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Anticonvulsants;Area;Automobile Driving;Benchmarking;Brain;Brain region;California;Characteristics;Child;Clinical Trials;Cognitive;cognitive benefits;cognitive rehabilitation;Communities;Control Groups;Cues;Data;Disease;Education;efficacy evaluation;Employment;Epilepsy;Exercise;exercise intervention;exercise program;exercise training;experience;Future;Generalized Epilepsy;Hippocampus;Impaired cognition;improved;Individual;infancy;Intervention;Intervention Studies;Investigation;life span;Literature;Magnetic Resonance Imaging;Mediating;Mediation;Mediator;Medical;Medical center;member;Memory;Memory impairment;memory retrieval;Modeling;neuroimaging;Operative Surgical Procedures;Outcome;Outcome Measure;patient population;Patients;Persons;Physical Exercise;Pilot Projects;Play;prevent;Productivity;programs;Quality of life;Randomized;Randomized, Controlled Trials;Regression Analysis;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Design;Research Priority;resistance exercise;Rest;Role;Sample Size;Seizures;Societies;Structure;Testing;United States National Institutes of Health;verbal;Verbal Learning;week trial

PROJECT_TITLE: Exercise for Memory Rehabilitation in Epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE:  Chronic stress causes molecular adaptations and structural remodeling of neurons, which leads to behavioral and cognitive deficits. Our work shows that neuronal activity-induced DNA double strand breaks (DSBs), which regulate the expression of genes that mediate experience-driven synaptic changes, are also increased in stress-activated neurons. By mapping the sites that incur DSBs following chronic stress and deciphering the role of DSBs in stress-induced gene activity patterns and neuronal remodeling, this project will enhance fundamental knowledge of how stressful experiences cause lasting changes in behavior.

PI_NAMEs: MADABHUSHI, RAM ;WOHLEB, ERIC S (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affect;Agonist;Architecture;Area;Atrophic;Automobile Driving;Behavior;Behavioral;Behavioral Symptoms;Brain;Brain region;Brain-Derived Neurotrophic Factor;Breeding;Candidate Disease Gene;candidate identification;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;Chromatin Loop;chromatin remodeling;Chromatin Structure;chromosome conformation capture;Chronic;Chronic stress;Clinical Research;Cognition;Cognitive;Cognitive deficits;cohort;Complex;Confocal Microscopy;density;Diazepam;DLG4 gene;DNA;DNA Double Strand Break;Early Promoters;Enhancers;Enzymes;Epigenetic Process;ERG gene;Etoposide;experience;experimental study;Exposure to;FOSB gene;FRAP1 gene;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome Mappings;genome-wide;genomic locus;Genotype;gephyrin;Heterochromatin;Hippocampus;Hour;Induced Neurons;Infusion procedures;inhibitor;insight;Knowledge;Label;lateral ventricle;Length;Major Depressive Disorder;Maps;Mediating;Mental disorders;Molecular;Mus;Nervous System Disorder;Neurobehavioral Manifestations;Neurobiology;Neurons;novel;novel therapeutic intervention;NPAS4 gene;osmotic minipump;Pathway interactions;Pattern;Poison;Post-Traumatic Stress Disorders;preclinical study;Prefrontal Cortex;promoter;Prosencephalon;Proteins;receptor;Recurrence;Reporting;Rodent;Role;Site;Sorting;Stress;Stressful Event;Structure;Synapses;Synaptic plasticity;Synaptosomes;Testing;Topoisomerase;transcriptome sequencing;Work

PROJECT_TITLE: The impact of stress-induced DNA breaks on chromatin structure, gene activity, and neuron function

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Physical Rehabilitation;Rehabilitation

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research will investigate how school-age children who were born preterm learn new motor skills, if there are differences in motor learning between preterm and term born children, and if this contributes to atypical movement development. Information about motor learning differences in preterm children can lead toward timely and targeted physical and occupational therapy interventions that may help improve motor abilities, allowing children to fully participate in school and maximize their independence as they mature toward adulthood.

PI_NAMEs: NEMANICH, SAMUEL THOMAS (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: 8 year old;Address;Adolescence;Adult;Affect;Age;Behavioral;Bilateral;Brain;brain behavior;Child;Child Health;Child Support;Childhood;Clinical;Clinical assessments;comparison group;Competence;computerized;Corpus Callosum;Development;Developmental Delay Disorders;dexterity;Evaluation;executive function;Exhibits;experimental study;Future;Hand;Impaired cognition;Impairment;improved;insight;Intervention;Investigation;Joystick;Laboratories;Lead;Learning;Learning Skill;Left;life span;Link;Literature;Manuals;Maps;Measures;Modeling;morphogens;Motor;motor deficit;motor impairment;motor learning;motor skill learning;Motor Skills;Movement;nervous system development;neural correlate;neurophysiology;Neurosciences;novel;Occupational Therapy;Outcome;Participant;Pattern;peer;Performance;Physical activity;Physical therapy;Play;Population;preference;Pregnancy;premature;Premature Birth;Process;Psychophysics;Questionnaires;recruit;rehabilitation strategy;Rehabilitation therapy;Research;Risk;Role;School-Age Population;Schools;skills;social engagement;Standardization;Structure;success;Techniques;Testing;Therapeutic Intervention;United States;Visual;visual motor;Work

PROJECT_TITLE: Motor skill learning in young children born preterm


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Women in the US Census racial/ethnic categories of Hispanic/Latina and Asian American/Pacific Islander have relatively lower incidence of breast cancer but are more likely to be diagnosed with the more aggressive human epidermal growth factor receptor (HER2) positive tumors compared to non-Hispanic White and non-Hispanic Black women. The use of European-centric research to predict cancer risk and prognosis in non-Europeans remains a critical barrier for equity in the implementation of precision medicine. The current proposed project aims to fill in the gap of knowledge regarding the genetic underpinnings of HER2 positive breast cancer in women of Latin American and Asian heritage, to enable the benefit of precision medicine in non-European populations, ensuring that the advances in medicine may be more equitably applied for public health in diverse populations.

PI_NAMEs: FEJERMAN, LAURA  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: African;American;American Indian Women;Asian;Asian Americans;Asian ancestry;Asian population;Asian Women;black women;Breast Cancer Genetics;breast cancer genomics;Breast Cancer Patient;Breast Cancer Risk Factor;Cancer Etiology;Cancer Prognosis;cancer risk;Categories;Censuses;Cessation of life;Chinese;clinically significant;cohort;Colombian;Data;Development;Diagnosis;Disease;Ensure;Epidermal Growth Factor Receptor;Equity;ERBB2 gene;Ethnic Origin;Etiology;European;follow-up;Frequencies;Gene Expression;Genes;Genetic;Genetic Complementation Test;Genetic Polymorphism;genetic predictors;Genetic study;genetic variant;Genome;genome wide association study;Genotype;Germ Lines;Germ-Line Mutation;Goals;high risk;Hispanic;Hispanic Populations;Hormone Receptor;hormone receptor-positive;Human;Human Genetics;improved;in silico;Incidence;Indigenous American;Individual;individualized prevention;insight;Knowledge;lapatinib;Latin American;Latina;Latina Population;Malaysian;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medicine;Mexican;migration;Modeling;Modernization;Molecular;Not Hispanic or Latino;Outcome;Pacific Islander;Participant;Pathway Analysis;Patients;Pattern;Pertuzumab;Peruvian;polygenic risk score;Population;Population Heterogeneity;precision medicine;Prevention strategy;Public Health;Race;Reporting;Research;Sampling;Singapore;targeted treatment;Testing;The Cancer Genome Atlas;Tissues;transcriptome;transcriptomics;Trastuzumab;treatment strategy;tumor;United States;Variant;White Women;Woman;Work

PROJECT_TITLE: Her2 status of breast cancer in diverse populations: improving genetic prediction and understanding molecular correlates

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]