NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The public health significance of this study lies in its potential to develop an improved understanding of how to effectively change breast cancer survivors' physical activity behavior. These findings could result in more effective, scalable physical activity interventions for this population, and ultimately, improve health outcomes and reduce healthcare costs associated with cancer recurrence, comorbidities, and premature death in breast cancer survivors.

PI_NAMEs: PHILLIPS, SIOBHAN MARIE (contact);VICTORSON, DAVID

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;Address;Adherence;Adoption;adverse outcome;Aftercare;Age;American Cancer Society;Anxiety;Awareness;Behavior;behavior change;Breast Cancer survivor;burden of illness;cancer care;Cancer Prognosis;cancer recurrence;cancer risk;Cancer Survivorship;Cellular Phone;Cessation of life;Chronic Disease;Communities;comorbidity;cost;design;Development;Diagnosis;Disease Outcome;disorder risk;Educational Intervention;Electronics;emotion regulation;Engineering;evidence base;Exercise;exercise intervention;experimental study;Fatigue;fitbit;follow-up;Funding;Goals;Health;Health behavior and outcomes;Health Benefit;Health Care Costs;Health Promotion;improved;improved outcome;Individual;innovation;Intervention;intervention effect;Knowledge;Light;Maintenance;Measures;Mediator;Mental Depression;Methodology;Methods;mHealth;mindfulness;Mindfulness Training;mortality;multiphase optimization strategy;Outcome;Physical activity;Population;Population Intervention;Posttraumatic growth;premature;programs;Psychosocial Factor;Public Health;Quality of life;Randomized;Recommendation;reduce symptoms;remote delivery;Research;Research Design;Research Methodology;Research Priority;Resources;response;Role;sedentary;Self Efficacy;self-compassion;Site Visit;Sleep;sleep quality;Social support;Survivors;Symptom Burden;symptom management;symptomatic improvement;Technology;telephone coaching;Testing;Text;Time;Treatment Side Effects;Treatment-Related Cancer;vigorous intensity;Work

PROJECT_TITLE: Fit2ThriveMIND: Optimizing a mHealth Physical Activity Intervention with Mindful Awareness Lessons in Breast Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Pain Research;Physical Activity;Prevention;Rehabilitation;Sleep Research

ORG_CITY: BRISBANE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF QUEENSLAND

PHR: PROJECT NARRATIVE The underlying premise of this research is that, for most, back pain is characterized by fluctuating symptoms with periods of worse symptoms referred to as “flares”, and that risk factors for flare will differ from those traditionally investigated as risks for the condition to begin or become chronic. This project will study risk factors for back pain flares through an innovative study of a diverse array of candidate biological/behavioral, psychological, social and environmental factors in the “real world” using advanced wearable and online technologies and more intensive data collection for a subset of participants to identify the underlying mechanisms. New understanding of what and how factors drive flares of back pain will provide foundational knowledge for new approaches to targeted management strategies on a case-by-case basis.

PI_NAMEs: HODGES, PAUL WILLIAM;KLYNE, DAVID M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;American;Award;Back Pain;Behavioral;Biological;Biomechanics;career;Caring;case-by-case basis;Chronic;Chronic low back pain;Clinical;cohort;Collaborations;cost;Cross-Over Studies;Crossover Design;Data;Data Collection;disability;Disease remission;Eligibility Determination;Environmental Risk Factor;Equilibrium;experience;Exposure to;Family;Flare;Foundations;Frequencies;global health;Health behavior;Home;Hour;improved outcome;Individual;innovation;insight;Interdisciplinary Study;International;Knowledge;Leisures;Link;Low Back Pain;Measures;Mediating;Methods;Modeling;Neuroimmune;Neuroimmunomodulation;novel strategies;Outcome;Pain;Pain management;Pain Research;Participant;Pathway interactions;Patients;personalized approach;personalized care;personalized intervention;Persons;Physical activity;Physical therapy;Physiological;poor sleep;prevent;Prize;psychologic;Psychological Factors;psychosocial;Quality of life;Reporting;Research;Research Personnel;Review Literature;Risk;Risk Factors;Sampling;Selection for Treatments;Self Management;skills;Sleep;Sleep Architecture;sleep quality;social;social factors;Societies;Symptoms;Technology;Testing;Time;Variant;Waxes;wearable device;wearable sensor technology;Work

PROJECT_TITLE: What causes low back pain to flare: Has a major opportunity to understand back pain been missed?

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative The proposed research is relevant to public health and RFA-HL-20-021 because it identifies blood-derived factors that influence the blood-brain-barrier (BBB) integrity. In this multi-PI application, we determine the mechanisms by which RBCs influence the removal of cilia (deciliation), a cellular organelle projecting from the endothelial cell surface into the CNS blood, which impacts BBB integrity in vitro and in vivo. The proposed research is directly relevant to NIH’s mission of employing preventive measures to block BBB leakage and integrity, and development of better fluid-based BBB models in vitro.

PI_NAMEs: NAULI, SURYA ;PALECEK, SEAN P;RAMCHANDRAN, RAMANI  (contact);RARICK, KEVIN R;ZENNADI, RAHIMA

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Active Biological Transport;Address;Adherence;Adhesions;Apical;Astrocytes;Biological Markers;Biology;Blood;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Blood Viscosity;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain Diseases;brain endothelial cell;Brain Injuries;Cell Adhesion;Cell Count;Cell surface;cell type;Cells;Cellular biology;Cellular Morphology;Cephalic;Cerebral Infarction;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Cilia;clinically relevant;Development;Disease;Endothelial Cells;Endothelium;Erythrocytes;Excision;Extravasation;Health;Hemorrhage;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;induced pluripotent stem cell;Injury;innovation;Knowledge;Length;Liquid substance;Mammals;Mediating;Microtubules;Mission;model development;Modeling;Monitor;mouse model;Mus;Neurons;neurovascular;neurovascular unit;Nude Mice;Organelles;Patients;Pericytes;Permeability;Phase;Phenotype;Preventive measure;Proteins;Protocols documentation;Public Health;recruit;Research;Research Personnel;Resistance;Rodent;Rodent Model;Role;sensor;severe injury;Sickle Cell;Sickle Cell Anemia;Side;Signal Transduction;Surface;Testing;Transgenic Organisms;Traumatic Brain Injury;United States National Institutes of Health;Zebrafish

PROJECT_TITLE: Cilia as a biomarker of CNS vascular health


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LOUISVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: RELEVANCE This proposal is to support research within the University of Louisville Superfund Center on the health effect of hazardous Superfund chemicals. Continued work in this Center will help in further evaluating the health impact of several hazardous chemicals that are present in the environment and in understanding how exposure to chemicals could contribute to the risk and development of obesity, diabetes and heart disease.

PI_NAMEs: SRIVASTAVA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Action Research;Advanced Development;Affect;Animal Experiments;Animal Model;animal tissue;Animals;Area;Atmosphere;Awareness;biobank;Biological;Biological Markers;Cardiology;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Chemical Exposure;Chemicals;Chemistry;Communities;community engagement;Community Outreach;computer code;Cost Measures;COVID-19;Critical Pathways;Data;Data Analyses;data archive;data management;data sharing;Data Storage and Retrieval;Decision Making;detection method;Development;Devices;Diabetes Mellitus;Disease Pathway;Education and Outreach;education research;education resources;Ensure;Environment;Environmental Exposure;Environmental Science;Epidemiology;Etiology;Evaluation;experience;exposed human population;Exposure to;fatty liver disease;Foundations;Funding;Future;Generations;Goals;graduate student;Growth;Hazardous Chemicals;Hazardous Substances;Hazardous Waste Sites;Health;Heart Diseases;Hepatology;Human;human population study;human tissue;Incidence;Industrialization;Injury;innovation;interest;Investigation;Knowledge;Mass Spectrum Analysis;Measures;member;Membrane;Metabolism;Methods;Molecular;new epidemic;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;obesity development;outreach program;Pathway interactions;pollutant;Population;Postdoctoral Fellow;Predisposition;Prevalence;Private Sector;Procedures;Process;programs;Public Health;Public Sector;remediation;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;resilience;Resources;response;Risk;Sampling;Science;self assembly;Severities;Site;Superfund;superfund chemical;superfund site;Technology;Tissue Sample;tool;Toxic effect;Toxicology;Training;Training Programs;translational medicine;Universities;Validation;volatile organic compound;Work

PROJECT_TITLE: Environmental Exposure and Cardiometabolic Disease


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Digestive Diseases;Endocrine Disruptors;Liver Disease;Prevention

PHR: NARRATIVE This project is to identify, assess, and evaluate the potential health effects due to exposure to hazardous chemicals prevalent in urban neighborhoods and areas around Superfund sites.

PI_NAMEs: BHATNAGAR, ARUNI  (contact)

PROJECT_TERMS: Acceleration;Acrolein;Affect;Air;Animals;Area;arterial stiffness;Atherosclerosis;attributable risk;Benzene;Bile Acids;Biological Markers;blood glucose regulation;Blood Platelets;Blood Pressure;blood pressure elevation;Blood Vessels;Butadiene;carcinogenicity;Carcinogens;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chemicals;Chronic;circulating biomarkers;cohort;Collaborations;Communities;County;Data;Data Analyses;data management;Development;Diabetes Mellitus;diabetes risk;Disease Progression;disorder risk;Dose;Environmental Exposure;Enzymes;Event;exposed human population;Exposure to;Farm;fatty liver disease;Formaldehyde;Functional disorder;Goals;Hazardous Chemicals;Health;Hepatic;Hepatocyte;Hepatotoxicity;Hospital Mortality;Hospitalization;Human;indexing;Individual;Injury;Insulin Resistance;Kentucky;Keratin;land use;landfill;Lipids;Liquid substance;Liver;liver biopsy;Liver diseases;Location;Measurement;Measures;Metabolic Diseases;Metabolism;MicroRNAs;Modeling;Monitor;monocyte;mortality;Neighborhoods;Participant;particle;Plasma;Population;primary endpoint;Process;response;Risk;Serology;Serum;Steatohepatitis;stem cells;Superfund;superfund site;Target Populations;Testing;Toluene;toxicant;Trichloroethylene;urinary;Variant;Vascular Diseases;vascular injury;volatile organic compound;wastewater monitoring;Water;Work;Xylene

PROJECT_TITLE: Project 1 - Cardiometabolic Injury due to VOCs


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative (Public Health Relevance Statement)  Protein glycosylation plays an important role in all kingdoms of life by regulating cellular responses to metabolic and environmental changes. Defects in protein glycosylation have been linked with abnormal plant development, parasitic virulence and viability, and a variety of human diseases, such as cancer, diabetes, and neurodegenerative diseases. Therefore, our proposed structural and functional studies of two distinct glycosyltransferases, SPY and SEC, and their opposing effects on key transcription regulators will reveal novel molecular insights into the genetic regulation by two distinct types of intracellular protein glycosylation: O- fucosylation and O-GlcNAcylation, with profound implications in agriculture and public health.

PI_NAMEs: SUN, TAI-PING ;ZHOU, PEI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;Agriculture;Allosteric Regulation;Anabolism;Animals;Arabidopsis;Bacteria;Binding;Biochemical;Biological Assay;Biology;Cell Physiology;Cells;Complex;Cryoelectron Microscopy;Defect;Diabetes Mellitus;Disease;Environment;environmental change;Enzymes;Event;Family;Fucosyltransferase;gene conservation;Genes;Genetic;genetic analysis;Genetic Transcription;Gibberellins;glycosylation;glycosyltransferase;Growth;Guanosine Diphosphate Fucose;Health;Human;human disease;Individual;Insecta;insight;Knowledge;Length;Life;Link;link protein;Malignant Neoplasms;Mediating;Metabolic;Modification;Molecular;Molecular Conformation;mutant;Mutation;N-terminal;nanobodies;Neurodegenerative Disorders;novel;O-GlcNAc transferase;Organism;paralogous gene;Phenotype;Phytochrome;Plant Growth Regulators;plant growth/development;Plants;Play;Protein Glycosylation;Proteins;Proteome;Proteomics;Public Health;public health relevance;Regulation;Resistance;response;Role;Sequence Homology;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Structure;Substrate Specificity;sugar;tool;transcription factor;Transcription Factor 3;Transcription Repressor;transcriptional reprogramming;Variant;Virulence

PROJECT_TITLE: Structural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in Plants

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE / PUBLIC HEALTH STATEMENT This project aims to bridge the gap between assistive devices and rehabilitative tools so that stroke patients with a paretic arm can immediately return to their daily routine and use their activities of daily living as a patient-specific rehabilitation strategy. Assistive bionic exoskeletons will be intuitively controlled with residual muscle activity from the paretic arm, and artificial intelligence will elucidate underlying muscle impairment, improve the dexterity of bionic devices, and temporarily assist and rehabilitate stroke patients. This proposal is relevant to NIH’s mission because it has strong potential to improve quality of life for stroke patients and their caregivers, as well as reduce overall healthcare costs.

PI_NAMEs: GEORGE, JACOB ANTHONY (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Affect;Agreement;Algorithms;arm paresis;Artificial Intelligence;Award;Bionics;career;career development;Caregiver Burden;Caregivers;Chronic;Clinical;Collaborations;Data Set;data visualization;Dedications;deep learning;Development;Development Plans;Devices;dexterity;disability;Doctor of Philosophy;Educational workshop;Electromyography;Event;exoskeleton;Faculty;faculty mentor;functional restoration;Funding;Goals;graduate student;Grant;Growth;Hand;handbook;Health Care Costs;hemiparetic stroke;High Performance Computing;holistic approach;Hospitals;HRK gene;Human Subject Research;Impairment;improved;Individual;innovation;Institution;Intuition;Knowledge;Leadership;lecturer;Machine Learning;Manuscripts;Mentors;Mentorship;Mission;Motor;Muscle;Muscle Spasticity;muscle strength;Nerve Regeneration;neurological rehabilitation;Neuromuscular Diseases;Orthotic Devices;Paresis;patient oriented;Patients;Physical Medicine;Physical Rehabilitation;Pilot Projects;post stroke;Postdoctoral Fellow;professor;Public Health;Publishing;Quality of life;Recovery;Rehabilitation Centers;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;Research Technics;Residual state;Running;Secure;Self-Help Devices;Services;skills;social;Societies;Spinal cord injury;strength training;Stroke;stroke outcome;stroke patient;stroke recovery;Students;symposium;System;tenure track;Time;tool;Training;Translational Research;Traumatic Brain Injury;undergraduate student;United States National Institutes of Health;Universities;Upper Extremity;upper limb hemiparesis;Utah;Vision;visual feedback

PROJECT_TITLE: Patient-centered rehabilitation and dexterous assistive devices for stroke patients using bionic exoskeletons controlled by non-invasive electromyography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


NIH_SPENDING_CATS: Cardiovascular;Nutrition;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Exposure to hazardous substances has been linked to the development or worsening of chronic disease. The purposes of this Superfund project are to understand how a particular class of compounds, i.e., volatile organic compounds, affect cardiovascular health and the onset or progression of diabetes, heart disease, and fatty liver disease as well as to develop therapeutic strategies to minimize these affect after exposure to toxic compounds.

PROJECT_TERMS: 1,3-Butadiene;2-butenal;Acceleration;Acrolein;Adipose tissue;Adult;Affect;Aldehydes;ambient air pollution;Animal Model;Apoptosis;Apoptotic;ATF6 gene;Atherosclerosis;Benzene;Biological;Biological Markers;biomarker identification;Blood Vessels;Body Burden;Butadiene;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiovascular health;cardiovascular injury;Cardiovascular Physiology;Cardiovascular system;Carnosine;Cell Physiology;Chemical Exposure;Chemical-Induced Change;Chemicals;Chronic Disease;Data;Deposition;design;Development;Diabetes Mellitus;diet-induced obesity;Disease Resistance;disorder risk;Dose;Drug Metabolic Detoxication;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;endothelial dysfunction;Endothelium;Environmental Exposure;Environmental Impact;Exposure to;Fatty acid glycerol esters;fatty liver disease;Formaldehyde;Functional disorder;Funding;Glutathione;Goals;Hazardous Chemicals;Hazardous Substances;Health;Heart Diseases;Heart failure;heart function;Heat shock proteins;Hepatic;High Prevalence;Human;Hypertension;indexing;Individual;Inflammatory;Inhalation;Injury;insight;Insulin Resistance;insulin sensitivity;Investigation;Link;Lipid Peroxidation;Lipids;Measures;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Molecular;Molecular Chaperones;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Nutritional status;Obesity;overexpression;Oxidative Stress;Oxidative Stress Induction;Parents;Pathway interactions;pharmacologic;Plasma;Platelet Activation;Poison;preclinical study;prevent;Process;Production;Property;protein folding;protein misfolding;Proteins;Protocols documentation;Reporting;response;Risk;Role;Signal Recognition Particle;Signal Transduction;Source;Stroke;Structure;Superfund;superfund site;Surveys;synergism;systemic inflammatory response;Testing;Therapeutic;therapeutic evaluation;therapy design;Tobacco smoke;Toxic effect;toxicant;Trichloroethylene;urinary;vascular inflammation;vascular injury;Vinyl Chloride;volatile organic compound;western diet;Work

PROJECT_TITLE: Project 2 - Molecular and Cellular Mechanisms of Cardiometabolic Toxicity of VOCs


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors;Health Effects of Indoor Air Pollution

PHR: RELEVANCE  This proposed work is to support continued research within the University of Louisville Superfund Research  Center on novel technologies to detect and quantify Superfund-relevant volatile organic compounds (VOCs) in  air. These technology platforms will be used to better understand VOC sources and human exposures.

PI_NAMEs: TURNER, JAY ROBERT (contact)

PROJECT_TITLE: Project 3 - Development and Field Application of Novel Ultrasensitive Devices for the Measurement of Airborne VOCs


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Pediatric

ORG_DEPT: GENETICS

PHR: The NIH supports projects that educate pre-college students, teachers and the public about NIH clinical and basic research, building public understanding of and support for this research. These pre-college/public projects also play an important role in developing the biomedical research workforce, providing opportunities for students to engage in research and envision a biomedical career. The annual NIH SciEd conference enhances each project’s work through sharing of best practices and lessons learned, interactions with NIH staff, networking, and developing cross-project collaborations.

PI_NAMEs: STARK, LOUISA A (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Area;Award;Basic Science;Behavioral Research;Biomedical Research;career;Clinical Research;Collaborations;college;Communication;Communities;Development;digital media;Doctor of Philosophy;Education;Educational Activities;Educational workshop;Evaluation;experience;Family;Feedback;Foundations;Funding;Goals;Grant;Health;health literacy;Incidence;Individual;instrument;interest;invention;Investments;Lead;Learning;meetings;member;Mentors;Methods;National Institute of General Medical Sciences;National Oceanic and Atmospheric Administration;Nursery Schools;Outcome;Participant;Persons;Play;posters;programs;Public Health;Reporting;Research;Research Support;Role;Science;science education;Science of genetics;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Small Business Innovation Research Grant;Small Business Technology Transfer Research;STEM program;Students;symposium;teacher;Time;trend;underserved community;United States National Aeronautics and Space Administration;United States National Institutes of Health;Universities;university student;Update;Utah;Video Recording;Videoconferencing;Washington;web site;Work;Youth

PROJECT_TITLE: NIH SciEd Conference

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal will seek to develop a novel microfluidic (“organ-on-chip”) model of the human blood-brain interface. Breakdown of this interface in several neurological diseases, including Huntington’s disease, Alzheimer’s disease, stroke and traumatic brain injury is thought to contribute to disease progression. Our platform will allow testing of new therapeutic approaches in an entirely human, animal free, model system.

PI_NAMEs: HUGHES, CHRISTOPHER C. W. (contact);THOMPSON, LESLIE MICHELS

PROJECT_TERMS: Acids;Affect;Alzheimer's Disease;Amyloid beta-Protein;Anastomosis - action;Animals;Arteries;Astrocytes;Basement membrane;Biological Models;Blood;Blood - brain barrier anatomy;Blood flow;Blood Glucose;blood perfusion;Blood Substitutes;Blood Vessels;Brain;brain cell;brain parenchyma;CADASIL;CAG repeat;Cell Communication;cell type;Cells;cerebral blood volume;Complex;Data;density;Development;Diagnostic;disease model;Disease Progression;drug development;Endothelial Cells;Face;foot;Foot Process;Gene Expression;Genes;Genetic;Glucose;Goals;Human;Huntington Disease;Huntington gene;in vitro Model;Individual;Insulin;Investments;Light;Lipids;Membrane;Microfluidics;Microglia;Modeling;Movement;Multiple Sclerosis;mutant;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurons;neuropathology;neurovascular;neurovascular unit;novel;novel therapeutic intervention;Organ;organ on a chip;Parkinson Disease;Pathogenesis;Pathology;Perfusion;Pericytes;Pharmaceutical Preparations;Phase;Phenotype;Physiological;polyglutamine;pressure;Process;Proteins;Regulation;response;Role;Running;Science;side effect;Signal Transduction;single-cell RNA sequencing;Stroke;Testing;Therapeutic;Tight Junctions;transcytosis;Transferrin;Translating;Traumatic Brain Injury;Vascularization;Veins;WNT Signaling Pathway;Work

PROJECT_TITLE: A Vascularized Micro-Organ platform for the study of Brain-BBB-Blood interaction


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PHR: NARRATIVE The overarching goal of this project is to develop and demonstrate novel, material-driven processes for new VOC treatment technologies. Based on the complex nature of VOC occurrence, the project is focused on advanced materials and related processes designed for broad capacity to efficiently treat a range of volatile organic molecules, in both the gas and liquid phase, with no continuous chemical supply, minimal/low energy inputs, resulting in benign products.

PI_NAMEs: FORTNER, JOHN  (contact)

PROJECT_TITLE: Project 4 - Advancing VOC Treatment with Novel Materials and Processes


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE CAR T cell therapy for solid tumors remains challenging in part due to inhibitory tumor microenvironments (TME) that are seen even at the earliest stages of cancer. We hypothesize that targeting the TME can mitigate these immunosuppressive effects and enhance CAR T cell killing of lung tumor. Our research strategy will develop a new immunocompetent mouse model that faithfully recapitulates the immunosuppressive TME to test novel therapeutic approaches to overcome these suppressive effects to ultimately advance CAR T cell therapy for solid tumors.

PI_NAMEs: AHMED, JALAL  (contact)

PROJECT_TERMS: Address;Adenocarcinoma Cell;antigen binding;Antigen Targeting;Appointment;Authorship;B lymphoid malignancy;B-Cell Leukemia;B-Lymphocytes;Binding;Biological Sciences;CAR T cell therapy;CD19 gene;cell killing;Cell Line;Cell Physiology;Cells;Chest;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Sciences;Clinical Trials;clinically relevant;course development;CRISPR/Cas technology;Cytokine Receptors;Data;Dedications;Doctor of Philosophy;Dose;effector T cell;Engineering;Enterobacteria phage P1 Cre recombinase;experience;experimental study;Foundations;Freedom;Generations;Genes;Genetic Recombination;Goals;Grant;Hematopoietic;Human;Immune;Immune response;Immunocompetent;Immunology;Immunosuppression;improved;Infiltration;Injections;innovation;interest;Label;Laboratories;Lead;Leadership;leadership development;Lentivirus;Lung;Lung Adenocarcinoma;Lung Neoplasms;Macrophage;Major Histocompatibility Complex;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Modeling;mouse model;Mus;neoplastic cell;novel;novel therapeutic intervention;Oncology;Outcome Study;overexpression;Paper;Patients;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;Prior Therapy;professor;programs;Radiation;Radiation Dose Unit;Radiation Oncology;Radiation therapy;radiological imaging;receptor;receptor binding;recruit;Regulatory T-Lymphocyte;Research;Research Personnel;Residencies;Resolution;response;safety testing;Science;Signal Transduction;Solid;Solid Neoplasm;success;T-Cell Immunologic Specificity;T-Cell Proliferation;T-Lymphocyte;Tail;Technology;Testing;theories;Therapeutic;timeline;tissue culture;TNFRSF5 gene;TNFSF5 gene;TP53 gene;Training;Translating;tumor;tumor microenvironment;tumor-immune system interactions;Validation;Veins;Work

PROJECT_TITLE: Advancing CAR T cell therapy for solid tumors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Depression remains one of the most significant challenges facing persons living with HIV infection. Neuroactive steroids are hormones produced by the body that can directly affect brain chemicals called neurotransmitters and some neuroactive steroids can affect the body’s immune system. This proposal will study the effect of neuroactive steroids on neurotransmitters and inflammation in people living with HIV on antiretroviral therapy to see if strategy helps with reducing depression.

PI_NAMEs: MUKERJI, SHIBANI SHARON (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adult;Affect;Analgesics;Animal Model;Anti-Anxiety Agents;anti-depressive agents;antiretroviral therapy;Automobile Driving;B-Lymphocytes;Behavior;Behavioral;behavioral response;Biological;biological adaptation to stress;Biological Markers;Biology;Blood;Brain;Cells;Cessation of life;Chemicals;Cholesterol;Chronic;chronic pain;Clinical;clinical predictors;cohort;Collaborations;Corpus striatum structure;Data;Depressed mood;depressive symptoms;design;disability;Disease;Disease remission;Double-Blind Method;Double-blind trial;Elements;Emotional;Enrollment;epidemiology study;financial incentive;Functional disorder;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Gene Expression Profile;Genes;Genetic Transcription;HIV;HIV Infections;Human;hypothalamic-pituitary-adrenal axis;Immune;Immune response;Immune system;Immunology;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Infrastructure;insight;Interferons;Interneurons;Knowledge;Laboratories;Lead;Left;Magnetic Resonance Spectroscopy;Measurement;Mediating;Mental Depression;Modeling;modifiable risk;monocyte;Mood Disorders;Multi-Institutional Clinical Trial;Nervous System Physiology;neural;neuroimaging;Neuropathogenesis;Neuropsychology;Neurosecretory Systems;neurosteroids;neurotoxicity;neurotransmission;Neurotransmitters;new therapeutic target;novel;Oral;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peripheral;Persons;Phenotype;placebo controlled trial;Placebos;Population;Positioning Attribute;preclinical study;predict clinical outcome;Pregnenolone;Prevalence;Property;Randomized;Reaction Time;Receptor Signaling;Research Personnel;responders and non-responders;response;reward expectancy;Risk Factors;screening;Severities;Site;steroid hormone;Supplementation;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic;Toll-like receptors;trial enrollment

PROJECT_TITLE: In Vivo Targeting of Neuroactive Steroid and Immune Networks for Depression in People Living with HIV.


NIH_SPENDING_CATS: Social Determinants of Health

PHR: RELEVANCE The Administrative Core is essential for the efficient functioning of the Center. It is required for the Center’s fiscal management and resource sharing, and will ensure quality control and compliance with regulations and evaluation of Center activities. It will facilitate and optimize research, training, community engagement, and research translational activities of the Center, and assist in developing a new understanding of the effects of hazardous chemicals on liver disease, diabetes and heart disease.

PROJECT_TERMS: Achievement;Administrator;Advisory Committees;Cardiometabolic Disease;Collaborations;Communication;Communities;community engagement;Consultations;Core Facility;Counseling;Data;Development;Diabetes Mellitus;Discipline;Education;effectiveness research;Emergency response;Ensure;Environment;Environmental Exposure;Evaluation;experimental study;federal policy;Focus Groups;Funding;Future;Goals;Hazardous Chemicals;Health;Health Professional;Heart Diseases;Human Resources;IACUC;Individual;Institution;Institutional Review Boards;Knowledge acquisition;Leadership;Link;Liver diseases;Logistics;Medical;meetings;member;Mentors;Monitor;National Institute of Environmental Health Sciences;Nongovernmental Organizations;operation;participant enrollment;Policies;Policy Maker;Productivity;programs;Progress Reports;Protocols documentation;Public Health;Quality Control;Reagent;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientific Evaluation;scientific organization;Scientist;Selection Criteria;Signal Recognition Particle;Specimen;Students;Superfund;tool;Training;Training Activity;Training and Education;training opportunity;Translational Research;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: RELEVANCE By ensuring proper study designs and supporting appropriate data analysis, and by providing efficient and organized data management and storage capabilities, the core will further our understanding of risk sources and cardiometabolic disease risk estimation due to exposure to hazardous chemicals. Well annotated data bases, created and supported by the core, will facilitate data sharing and collaborative projects within the Center and with other Superfund Centers and academic institutions.

PI_NAMEs: RAI, SHESH N. (contact)

PROJECT_TERMS: Anacondas;Animal Experiments;Animals;archive data;Artificial Intelligence;Atmosphere;Basic Science;Bioinformatics;Biological Assay;Biometry;Cardiometabolic Disease;cardiometabolism;central database;Characteristics;Clinical Investigator;Clinical Research;Clinical Trials;Code;cohesion;Collaborations;computing resources;Consultations;Data;Data Analyses;Data Collection;data curation;data dictionary;data exchange;Data Files;data harmonization;data hub;data interoperability;data management;data quality;Data Set;data sharing;Data Storage and Retrieval;data streams;data structure;data submission;Databases;design;detection limit;Development;Dimensions;Disease;disorder risk;education resources;Educational workshop;efficacy testing;Ensure;Environment;Environmental Exposure;epidemiology study;Evaluation;experience;experimental analysis;Experimental Designs;Exposure to;Faculty;FAIR principles;Fostering;Funding;Future;Gases;Geography;graduate student;Hazardous Chemicals;Health;Health protection;Human;Human Resources;improved;Individual;innovation;Institution;land use;large datasets;Linux;lipidomics;Machine Learning;Manuscripts;Maps;Mass Spectrum Analysis;Measurement;meetings;metabolomics;Methods;Modeling;Molecular;novel;novel strategies;Operating System;operation;Output;Participant;platform-independent;pollutant;Population;portability;Postdoctoral Fellow;preclinical study;Preparation;Prevention;privacy protection;Procedures;Process;Protocols documentation;Pythons;quality assurance;Quality Control;remediation;repository;Research;Research Design;Research Personnel;Resources;Risk;Risk Assessment;Risk Estimate;Sampling;Scientist;Secure;Series;Services;Site;Source;Spatial Distribution;Specimen;Statistical Data Interpretation;Statistical Methods;statistical service;Study Subject;Superfund;Testing;tool;Toxic effect;Training;transcriptomics;Translational Research;Universities;usability;Validation;Variant;Visual;volatile organic compound;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: LITTLE ROCK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Shigella is a gastrointestinal pathogen that cause bloody diarrhea, resulting in mortality and morbidity worldwide, especially among children under ages of 5. Our study examines Shigella- host innate immune defenses to identify target (s) that will help to improve vaccines design.

PI_NAMEs: AACHOUI, YOUSSEF  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Actins;Acute Diarrhea;Age;antimicrobial;Arginine;Arginine deiminase;Automobile Driving;Bacteria;Calcium;CASP1 gene;Cell Compartmentation;Cell Death;Cells;Chemotactic Factors;Child;Chromatin;Citrulline;content retention;cost;Cytoskeleton;Cytosol;Detection;Disease;DNA Structure;enteric pathogen;Epithelial Cells;Epithelium;extracellular;gastrointestinal;gut colonization;Hemorrhagic colitis;Histones;Immobilization;Immune;Immunity;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory Response;Interleukin-1 beta;intestinal epithelium;Invaded;Licensing;Macrophage;Mediating;member;Membrane;Microtubules;Modeling;Morbidity - disease rate;mortality;Motility;Mus;neutrophil;Neutrophil Infiltration;novel;Nuclear Envelope;Organelles;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Phagocytes;physiologic model;Pilot Projects;Play;prevent;Relaxation;Resistance;Role;Rupture;sensor;Shigella;Shigella flexneri;Shigella Infections;Side;Signal Transduction;Sterility;Structure;Swelling;Type III Secretion System Pathway;Vaccine Design;Vaccines;Vacuole;Virulence

PROJECT_TITLE: Pyroptotic Macrophages Traps Against Shigella Infection

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  This project is aimed to characterize the functional neural circuits that enable the crosstalk between the brain and the stomach. We will use an array of cutting-edge technologies to find out how the stomach sends its electrical, mechanical, and chemical states to the brain, and how the brain controls the stomach and maintains homeostasis. The knowledge established from this project will enable better understanding of the “gut feeling” and inform better treatment of digestive or mental illnesses.

PI_NAMEs: CHEN, JIANDE ;LIU, ZHONGMING  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Address;Affect;Animals;Anxiety;awake;Brain;brain control;Brain Mapping;Brain region;Carbohydrates;cell type;Central Nervous System;Chemicals;Cognition;Complex;connectome;Coupled;Coupling;Digestion;Disease;Dorsal;Dyspepsia;Eating;Efferent Neurons;Electrophysiology (science);Emotions;Enteric Nervous System;Fasting;Fatty acid glycerol esters;Feeling;Food;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Gastroenterology;Genetic;Health;Herpesvirus 1;Homeostasis;Human;Inflammatory;Infusion procedures;Ingestion;Interoception;Intuition;Knowledge;mad itch virus;Magnetic Resonance Imaging;Maps;Mechanics;Mediating;Mental disorders;Migrating Myoelectric Complex;Monitor;Motility;motor control;Nerve;Nervous System Disorder;neural circuit;Neural Pathways;Neuroanatomy;Neurologic;neuroregulation;neurotransmission;Nodose Ganglion;Nutrient;Outcome;Parkinson Disease;Peripheral;pharmacologic;pressure;Proteins;Rattus;Reflex action;Regulation;Rest;Role;Sensory;Signal Transduction;Stomach;Stress;Technology;Testing;Vagotomy;Vagus nerve structure;Viscera

PROJECT_TITLE: Functional Neural Circuits of Stomach-Brain Interoception


PHR: Relevance: The overall goal of the Research Experience and Training Coordination Core (RETCC) is to direct successful training of graduate students and post-doctoral fellows (designated ‘trainees’) in the University of Louisville Superfund Research Center (ULSRC). This includes scientific interdisciplinary training within defined ULSRC projects and cores as well as promoting development of a broad knowledge base and the skills needed to communicate and engage with relevant community partners, government liaisons and health-care professionals regarding the importance of environmental health sciences research in the Superfund Program.

PI_NAMEs: HEIN, DAVID W (contact)

PROJECT_TERMS: Advisory Committees;Age;Arts;Award;Awareness;Cardiometabolic Disease;cardiometabolism;career;career development;Chemistry;cohort;Collaborations;college;Communication;Communities;community engagement;Community Health Education;community partners;community research;Congresses;County;Data;Data Analyses;data management;Dentistry;Development;Discipline of Nursing;Disparate;Engineering;Environmental Exposure;Environmental Health;experience;Exposure to;Fellowship;Fertilization;field trip;Fostering;Goals;Government;graduate student;Growth;Hazardous Substances;Health;Health Professional;health science research;Human;innovation;Institution;interdisciplinary approach;Kentucky;knowledge base;Laboratories;Medicine;meetings;Metals;Mission;multidisciplinary;National Institute of Environmental Health Sciences;next generation;Pennsylvania;Phase;Play;Policies;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Publications;Research;Research Project Grants;Role;Schools;Science;Scientist;Signal Recognition Particle;skills;Statistical Data Interpretation;Students;success;Superfund;superfund site;Training;Training Activity;training opportunity;Training Programs;Training Support;Translational Research;Universities;Washington;Work


NIH_SPENDING_CATS: Prevention

PHR: RELEVANCE The primary function of the research within the Metabolism and Toxicity Core is to measure environmental exposures and their resulting effects on health. Using state-of-the-art analytical approaches to measure urine and blood components, the core will provide quantitative data on the extent of chemical exposures, and the extent to which these exposures cause injury and dysfunction.

PI_NAMEs: O'TOOLE, TIMOTHY E (contact)

PROJECT_TERMS: Address;Analytical Chemistry;Animals;Bile Acids;Biochemical;Biological Assay;Biological Markers;Biology;Blood;blood glucose regulation;Bone Marrow;Cardiometabolic Disease;cardiometabolism;Cardiovascular system;career development;Catecholamines;Cells;Chemical Exposure;Clinical;Clinical Pathology;Communities;Complex;Continuing Education;Data;Data Analyses;data dictionary;data harmonization;data management;Data Reporting;Deposition;Detection;Development;Dimensions;Education;Ensure;Environmental Exposure;Environmental Health;Equipment;Exposure to;Extramural Activities;Faculty;flexibility;Flow Cytometry;Foundations;Functional disorder;Future;Goals;graduate student;Growth;Health;Hepatic;Hepatotoxicity;Histologic;Human;Human Resources;indexing;Individual;Infrastructure;Injury;innovation;interest;investigator training;Laboratories;liquid chromatography mass spectrometry;liver function;Measurement;Measures;meetings;member;Metabolic;Metabolism;Methodology;Methods;Mus;next generation;novel;operation;particle;Pathologic;Pathology;Physiological;Population;Postdoctoral Fellow;Procedures;Property;Protocols documentation;Quality Control;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk Assessment;Sampling;Scientist;Services;Signal Transduction;Students;Superfund;superfund chemical;systemic toxicity;Technical Expertise;Techniques;Technology;Testing;Toxic effect;Toxicology;Training;Training and Education;Universities;urinary;Urine;volatile organic compound

PROJECT_TITLE: Metabolism and Toxicity Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE  Development of medicines requires technology for rapid and efficient synthesis of new molecules. This project will develop of a novel platform for high-throughput reaction development and discovery based on engineering enzymes using nanoliter droplet technology and high-throughput analytical systems compatible with organic reactions. By providing access to enhanced throughput and miniaturization, this technology will accelerate pharmaceutical discovery and development in a time and resource efficient manner.

PI_NAMEs: KENNEDY, ROBERT T (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Achievement;advanced analytics;Amino Acids;Award;catalyst;Cells;cellular engineering;Chemical Engineering;chemical synthesis;Chromatography;Clinical Trials;Complex;cost;Coupling;Cytochrome P450;Detection;Development;DNA;drug synthesis;Encapsulated;Engineering;Enzymes;Escherichia coli;Evaluation;Evolution;experimental study;Fluorescence;functional group;Genetic Transcription;Goals;improved;In Vitro;Incubated;Individual;Industrialization;Investigation;ion mobility;ionization;Isomerism;Label;Lead;liquid chromatography mass spectrometry;Manufacturer;Mass Spectrum Analysis;Measurement;Mediating;Medical;Medicine;Metals;Methods;Microbe;Microfluidics;Miniaturization;Mutation;nanolitre;Nobel Prize;novel;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Preparation;Process;Production;Protocols documentation;Pyridoxal Phosphate;Reaction;Resources;Rhodium;Robotics;Sampling;screening;Signal Transduction;Sorting;Spectrometry, Mass, Electrospray Ionization;Speed;Structure-Activity Relationship;System;Technology;Testing;Time;tool;Toxic effect;Translations;uptake;Variant;Work;Yeasts

PROJECT_TITLE: Microfluidic Systems to Enable Enzyme Engineering for Chemical Synthesis

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Relevance: We are beginning to understand that toxin exposure can initiate/exacerbate multiple adverse health outcomes, especially cardiometabolic diseases. Kentuckians are disproportionately affected by many chronic diseases, including obesity, hypertension, heart disease, diabetes, fatty liver disease, etc., which are all aspects of cardiometabolic syndrome. Certain communities are more highly impacted than others, and it is critical to understand why. We hypothesize that exposure to toxics, specifically VOCs, initiates/exacerbates these conditions. It is fundamental to our understanding of the effects of these toxics to engage the communities most deeply affected by exposure to these pollutants and to try to mitigate the effects of these exposures. Thus, determining the influence of pollutant exposures on the development/progression of these chronic conditions is vital. Also vital is examining this influence within the proposed areas within West and Southwest Louisville, Kentucky that face added social environmental health burdens, including an uneven distribution of race and ethnicity, a traumatic introduction into the racial reckoning, historic redlining, and poverty. Bidirectional research in this community will support understanding of the impacts of VOCs on cardiometabolic disease and community empowerment.

PI_NAMEs: HEBERLE, LAUREN  (contact)

PROJECT_TERMS: Address;Affect;Air;Area;Awareness;biological systems;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chronic;Chronic Disease;Communication;Communities;community advisory board;community center;community empowerment;community engaged approach;community engagement;community involvement;community partners;Development;Diabetes Mellitus;Elements;Ensure;Environmental Engineering technology;Environmental Exposure;Environmental Health;Environmental Science;Equipment and supply inventories;Ethnic Origin;Exposure to;Face;Farm;fatty liver disease;Geographic Locations;Goals;Green space;Hazardous Substances;Hazardous Waste;Health;health disparity;Health Food;Health Sciences;Heart Diseases;Home;Housing;Hypertension;Industry;Institution;interest;Intervention;Kentucky;Knowledge;landfill;meetings;member;Natural Sciences;Neighborhoods;Obesity;Outcome;Patient Recruitments;Persons;Play;Policy Maker;pollutant;Population;Populations at Risk;Poverty;Prevention;Productivity;Race;Research;Research Personnel;Research Project Grants;Resources;Risk;risk mitigation;Role;Science;Site;social;Social Sciences;Source;Structural Racism;Superfund;superfund site;Syndrome;therapy design;Toxic effect;Toxin;Training;Transcend;Transportation

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Hematology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Disruption of blood brain barrier (BBB) is a hallmark in traumatic and other brain injuries. However, the influences of blood on the structure and function of BBB in both resting and disease states remain poorly understood, largely due to the lack of appropriate BBB models and. In this project, we have assembled an interdisciplinary team with expertise in microvascular engineering and vascular biology, hematology and hemostasis, TBI, and cell signaling to reconstruct human BBB, and exploit roles of blood derived factors in maintaining and disrupting the BBB integrity and function, to identify intracellular signal pathways that contribute to BBB breakdown in TBI.

PI_NAMEs: DONG, JING-FEI ;ZHENG, YING  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Aging;Alzheimer's Disease;Architecture;Astrocytes;Biochemical;Biological Assay;Biological Models;Biology;biomarker development;Biomechanics;Blood;Blood - brain barrier anatomy;Blood Coagulation Disorders;Blood flow;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain Injuries;brain parenchyma;Cause of Death;Cell Communication;cell injury;Cells;Central Nervous System;Cerebral hemisphere hemorrhage;cerebral microvasculature;Cerebrum;Chronic;Circulation;Clinical;Complex;Critical Pathways;defined contribution;Development;Devices;diagnostic biomarker;disability;Disease;Edema;Electron Microscopy;Endothelial Cells;Engineering;Extracellular Fluid;extracellular vesicles;Future;Heart;Hematology;Hemostatic function;Homeostasis;Human;improved outcome;In Vitro;in vivo;Inflammatory;injured;Injury;insight;Intracranial Hemorrhages;Intracranial Hypertension;Ischemia;kinase inhibitor;light microscopy;Lung;Mediating;Microglia;Modeling;monolayer;mouse model;Nervous System Disorder;neurovascular;neurovascular unit;new therapeutic target;Organ;Patients;Pattern;Pericytes;Permeability;Phase;Phosphotransferases;Physiological;Plasma;Prognostic Marker;Regression Analysis;repaired;Reporting;response;Rest;Role;Sampling;Secondary to;Severities;shear stress;Signal Pathway;Signal Transduction;Site;Stroke;Structure;Study models;success;System;systemic inflammatory response;Systems Biology;TBI Patients;Technology;therapeutic development;therapeutic target;three-dimensional modeling;Tissues;Trauma;Traumatic Brain Injury;Venous;young adult

PROJECT_TITLE: 3D Models of the Blood-Brain Barrier for Studying Trauma-Induced Cerebral and Systemic Injuries


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE The implementation of precision medicine requires physicians and scientists who have been trained to understand how genomic diversity in humans causes both rare and common diseases across the life span, and who are capable of translating that knowledge into clinical testing and new treatments to improve human health. This T32 program supports the training of the next generation of outstanding academic M.D. and translational Ph.D. investigators in medical genetics and genomics.

PI_NAMEs: HISAMA, FUKI MARIE (contact);JARVIK, GAIL PAIRITZ

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Medical Genetics Postdoctoral Fellowship


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Membrane proteins are embedded in the chemically complex lipid environment of the biological membrane. Lipids have crucial roles in regulating the function of membrane proteins. Here, we seek to not only to develop new methods and reagents but also push technological limits to better understand how lipids interact with membrane proteins and modulate their function.

PI_NAMEs: LAGANOWSKY, ARTHUR D (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Ammonia;Binding;Binding Sites;Biological;Biological Models;Biology;biophysical techniques;Cardiolipins;Charge;Chemicals;Collaborations;Complex;Cryoelectron Microscopy;Crystallography;Custom;Cysteine;Data;density;design;Detergents;Development;Engineering;Environment;Escherichia coli;Event;fluorophore;Foundations;genetic regulatory protein;Goals;Individual;insight;Integral Membrane Protein;Knowledge;Label;Laboratories;Length;Lipid Binding;Lipid Chemistry;Lipids;Location;Maps;mass spectrometer;Mass Spectrum Analysis;Membrane;Membrane Fluidity;membrane model;Membrane Proteins;Membrane Structure and Function;Methods;Molecular;mutant;novel strategies;Outcome;Physiological;Physiological Processes;pi bond;Point Mutation;Positioning Attribute;preservation;protein complex;Protein Engineering;Proteins;Reagent;recruit;Research;Resolution;response;Role;stereochemistry;Structure;Surface Plasmon Resonance;System;Tail;Technology;Temperature;Thermodynamics;Time;tool;Work;X-Ray Crystallography

PROJECT_TITLE: Developing new tools to probe membrane protein-lipid interactions for biomedical applications

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases

PHR: PROJECT NARRATIVE Genetic testing is rapidly emerging as a cornerstone of medicine, enabling targeted therapies for patients with both common and rare disorders, and empowering patients, families and communities with knowledge about their condition. However, despite significant advances over the past decade, including the introduction of clinical whole genome sequencing, clinical genetics remains largely limited to the study of less than 1% of the genome, the exome. Here we leverage a novel approach for simultaneously mapping the genetic and epigenetic landscape of a sample to elucidate the functional impact of rare non-coding sequence and structural variants on gene regulatory patterns and monogenic human disorders.

PI_NAMEs: STERGACHIS, ANDREW BEN (contact)

PROJECT_TERMS: Address;Appointment;Architecture;Area;Award;Chromatin;Chromosome Mapping;Clinical;clinical training;Communities;Complex;Defect;Disease;disease-causing mutation;empowerment;Epigenetic Process;epigenome;Etiology;exome;exome sequencing;Family;Financial Support;Genes;Genetic;genetic testing;genetic variant;Genetic Variation;Genome;genome sequencing;Genomic approach;Genomic medicine;Genomics;Goals;Human;human disease;Human Genetics;imprint;improved;Individual;Institution;Knowledge;laboratory equipment;Lead;Medical;Medical Genetics;Medicine;Mendelian disorder;Mutation;novel strategies;Nucleotides;Pathogenicity;Patients;Pattern;Persons;Phenotype;Positioning Attribute;Postdoctoral Fellow;professor;Rare Diseases;Research;Research Proposals;Resolution;Resources;Role;Sampling;Scientist;Sequence Homology;Single Nucleotide Polymorphism;success;targeted treatment;Technology;Testing;translational genomics;United States National Institutes of Health;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Investigating the contribution of non-coding genetic variation to rare disorders


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Precision Medicine;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Obstructive Sleep Apnea (OSA) is a serious health concern. The physiological consequences of OSA are in- adequately characterized and their impact on health outcomes remains incompletely understood. The pro- posed research is expected to identify markers of OSA not only to better characterize its physiological burden (i.e. hypoxemia, surges in heart rate/blood pressure, and sleep fragmentation) but also to identify high-risk in- dividuals and prioritize them for effective treatments.

PI_NAMEs: AZARBARZIN, ALI  (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Acute;Adherence;Adverse event;adverse outcome;Affect;airway obstruction;Apnea;Arousal;Attention;automobile accident;Biological Markers;biomarker identification;Blood gas;Blood Pressure;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Caring;Clinical Trials;Confusion;Continuous Positive Airway Pressure;Data;Diagnosis;Disease;Drowsiness;effective therapy;Endothelium;Event;Excessive Daytime Sleepiness;Exhibits;Failure;follow-up;Goals;Grant;Health;Health Benefit;Heart failure;Heart Rate;high risk;high risk population;Hour;Hypoxemia;Hypoxia;improved;indexing;Individual;individualized medicine;Knowledge;Link;Measures;Mediating;men;Methods;Monitor;mortality;Neurocognitive;Neurocognitive Deficit;Nitrates;Nitric Oxide;Nitrites;novel;Observational Study;Obstructive Sleep Apnea;Outcome;Outcome Assessment;Oxidative Stress;Pathogenicity;Pathway interactions;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Persons;Pharyngeal structure;Phenotype;Physiological;Plasma;prevent;Prognostic Marker;Quality of life;Research;response;Risk;Severities;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;Splint Device;Sympathetic Nervous System;Telephone;Testing;Therapeutic;Time;Vasodilation;vigilance;Visit;Woman;Work

PROJECT_TITLE: Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: The devastating consequences of ethanol consumption during pregnancy has reached epidemic proportions worldwide. Neurobehavioural defects and anomalies of the head and face are widely recognized consequences in children of mothers who drank alcohol during pregnancy, but at least 30-40% of the babies have serious heart defects. We will test how alcohol changes gene expression in the developing heart and then trial dietary compounds, currently available as over the counter supplements, for their efficacy in preventing the serious and costly effects of prenatal alcohol exposure on heart development.

PI_NAMEs: FORD, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Affect;alcohol abstinence;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;alcohol testing;Alcohols;animal model development;Betaine;Birds;bisulfite sequencing;Carbon;Cardiac;cardiogenesis;career;career development;Child;Childhood;Choline;Choline Deficiency;choline supplementation;Clinical;Clinical Trials;cohort;comparative genomics;congenital heart abnormality;Congenital Heart Defects;cost;Craniofacial Abnormalities;Critical Pathways;Data;Defect;design;Development;Development Plans;dietary;Disease;DNA;DNA Methylation;DNA Sequence;Educational process of instructing;Embryo;embryonic alcohol exposure;Embryonic Heart;Epidemic;Epigenetic Process;Ethanol;experience;experimental study;Face;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fluorescent in Situ Hybridization;Fostering;Future;gastrulation;Gene Expression;Genes;Genome;Glutathione;Growth;HAS2 gene;Head;Health;Heart;Heart Abnormalities;heart defect;Heavy Drinking;High Prevalence;Human;Hypermethylation;Image;Individual;Infant;Laboratories;laboratory experience;Life;Mentors;Mentorship;Metabolism;Methylation;methylation pattern;Modeling;Mothers;mouse model;Mus;Neurologic Effect;Newborn Infant;novel;Optical Coherence Tomography;optical imaging;Outcome;Pathogenesis;Pathway interactions;Phenotype;Physicians;placental mammal;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention;Prevention strategy;Productivity;Quail;Recommendation;Research;Research Personnel;RNA;Scientist;septal defect;Site;skills;Structure;Supplementation;Surgeon;Training;Transforming Growth Factor beta;United States National Institutes of Health;Universities;Vertebrates;Work;XCL1 gene

PROJECT_TITLE: Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE Adolescents and young adults (AYAs) who undergo hematopoietic cell transplantation (HCT) are at an especially high risk of developing sarcopenia (loss of skeletal muscle mass), which occurs earlier than would be expected from advancing age alone, and both doubles their risk for non-relapse mortality and leads to premature cardiovascular disease. We propose a mechanistic randomized controlled trial of home-based remotely supervised exercise (aerobic and resistance) training and supplementation with nicotinamide riboside, a precursor of NAD+, a metabolite that is critical for muscle metabolism, in AYA survivors of HCT. Our findings will lay the critical groundwork for future trials to prevent or mitigate the myriad downstream adverse effects of low muscle mass in AYA HCT survivors, an important area of shared strategic focus for the NCI and NHLBI.

PI_NAMEs: MCCORMACK, SHANA ERIN;MOSTOUFI-MOAB, SOGOL  (contact)

PROJECT_TERMS: acylcarnitine;Address;Adolescent and Young Adult;Adult;Adverse effects;Aerobic;Aerobic Exercise;Age;Aging;Animal Model;Area;arm;Biometry;Cancer Survivorship;Cardiology;Cardiopulmonary;Cardiovascular Diseases;Child;Chronic;clinically relevant;cofactor;Combined Modality Therapy;comorbidity;design;Development;Dual-Energy X-Ray Absorptiometry;Elderly;Endocrinology;Excess Mortality;Exercise;exercise capacity;Exercise Test;exercise training;fitness;Future;Glucocorticoids;graft vs host disease;growth hormone deficiency;Heart;Hematopoietic Stem Cell Transplantation;high risk;High-Risk Cancer;Home;Human;Hypogonadism;Imaging Techniques;Immunosuppression;improved;indexing;Individual;Inflammation;innovation;Intervention;intervention effect;Leg;Long-Term Survivors;Lung;Magnetic Resonance Imaging;Malnutrition;Measures;Mediating;Metabolism;metabolome;metabolomics;mimetics;Mitochondria;mitochondrial metabolism;Morbidity - disease rate;mortality;multidisciplinary;Muscle;muscle form;Muscle function;muscle metabolism;Muscle Mitochondria;muscle strength;Muscular Atrophy;Musculoskeletal System;Myopathy;National Heart, Lung, and Blood Institute;Nicotinamide adenine dinucleotide;nicotinamide riboside supplementation;nicotinamide-beta-riboside;non-invasive imaging;novel;Oral;organic acid;Outcome;Oxidative Phosphorylation;Oxygen;Patients;Physical activity;physical inactivity;Physiological;Population;premature;prevent;primary outcome;Production;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduced muscle mass;Research;Research Priority;Resistance;resistance exercise;response;Risk;Risk Factors;sarcopenia;secondary outcome;sedentary;Skeletal Muscle;skeletal muscle wasting;Supplementation;Survivors;Testing;therapy design;Thinness;Toxic effect;Training;transplant survivor;Transplantation Conditioning;Treatment-Related Cancer;Vascular System;VO2max

PROJECT_TITLE: Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Services;Social Determinants of Health

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE This proposal requests support to maintain the high-quality data and streamline the innovative infrastructure of the prospective California Teachers Study (CTS). During the next five years, as the CTS's 133,477 female participants pass through ages of high disease risk, we will conduct efficient linkages that capture new cancer, inpatient and outpatient hospitalization, mortality, and geospatial data. Together with the CTS's commitment to facilitating open and broader use of its resources, this will create additional opportunities for impactful research on understudied areas of cancer risk and outcomes.

PI_NAMEs: LACEY, JAMES V (contact);MARTINEZ, MARIA ELENA

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Achievement;Address;Age;Aging;Air Pollution;Aliquot;anti-cancer research;application programming interface;Area;Authorization documentation;Award;Biological Markers;Blood specimen;built environment;California;cancer epidemiology;cancer risk;cancer therapy;Cessation of life;Characteristics;climate data;Clinical;cloud based;Cloud Computing;cohort;Cohort Studies;Collaborations;Collection;Communities;comorbidity;Complement;Complex;Data;Data Analyses;Data Collection;Data Commons;Data Mart;data modeling;data sharing;data visualization;data warehouse;disorder risk;eligible participant;Emergency department visit;Ensure;Environment;Environment Design;Environmental Exposure;Epidemiology;Essential worker;Etiology;extreme weather;FAIR principles;Female;flexibility;follow-up;Foundations;Future;Goals;Green space;handheld mobile device;Health;health care service utilization;Health Planning;Health Services;Health Services Research;high risk;Hospitalization;human old age (65+);Individual;Infrastructure;innovation;Inpatients;Light;Link;Longitudinal Studies;Maintenance;Malignant Neoplasms;Manuals;Medicare;Medicare claim;Metadata;Modernization;mortality;neoplasm registry;operation;Outcome;Outpatients;Participant;patient engagement;Phase;phenotypic data;Positioning Attribute;preservation;Process;prospective;Protocol Compliance;Public Health;Reporting;Reproducibility;Request for Proposals;Research;Research Personnel;research study;resilience;Resources;Sampling;Sampling Studies;Secure;Services;Shipping;social;social vulnerability;Solid;Specimen;Surveys;survivorship;teacher;Time;tool;Update;UV Radiation Exposure;Vital Status;volunteer

PROJECT_TITLE: Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Cancer is a systemic disease. Cancer growth and metastasis relies not only on the intrinsic aberrant genetic and epigenetic makeup of tumor cells, but also on the tumor-induced systemic factors which impact cells in local and distant microenvironments, affecting all organ systems in the body. This proposal aims to dissect the complex interactions between the tumor and its host using multidisciplinary approaches, paving the way to rational targeted therapies that can effectively hinder metastasis.

PI_NAMEs: LYDEN, DAVID CHARLES (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Affect;Albers-Schonberg disease;Blood Vessels;Body System;Bone Density;Cachexia;Cancer Model;Cancer Patient;Cells;chemokine;Coagulation Process;Code;Communication;Complex;cytokine;Development;Distant;DNA;Epigenetic Process;exosome;Genetic;Growth;Hematopoietic;Heterogeneity;Immune system;Immunosuppression;Inflammation;interdisciplinary approach;Interruption;Liver Failure;lung failure;Malignant - descriptor;Malignant Neoplasms;Metabolic;Muscle;nanovesicle;Neoplasm Metastasis;neoplastic cell;Neuropathy;novel;novel strategies;Organ;Osteoporosis;particle;Proteins;Regulation;Role;Shapes;Systemic disease;targeted treatment;Tissues;tumor;Tumor-Derived;Untranslated RNA

PROJECT_TITLE: Systemic regulation of metastasis


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetic Testing;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE The proposal aims to validate an imaging biomarker to assess estrogen receptor function and to predict response to therapy with the goal of identifying patients who will benefit from endocrine therapy-based approaches so that chemotherapy could be avoided or delayed.

PI_NAMEs: DEHDASHTI, FARROKH ;MA, CYNTHIA X;SHOGHI, KOORESH ISAAC (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Address;adjuvant endocrine therapy;advanced breast cancer;Agonist;arm;Aromatase Inhibitors;Biological Markers;Biopsy;Breast Cancer cell line;Breast Cancer Patient;CDK4 gene;chemotherapy;Clinic;Clinical;clinical development;Clinical Trials;Combined Modality Therapy;Data;Disease;Disease Progression;DNA Sequence Alteration;Enrollment;Epidermal Growth Factor Receptor;ESR1 gene;Estradiol;Estrogen decline;Estrogen receptor positive;Estrogen Receptor Status;Estrogen Receptors;Estrogens;exome sequencing;experience;FPS-FES Oncogene;Fulvestrant;functional genomics;functional status;Gene Expression Profile;Gene Mutation;Genetic Engineering;genetic signature;Genetically Engineered Mouse;genomic signature;Genomics;GNRH1 gene;Goals;hormone therapy;Human;Image;imaging biomarker;improved;indexing;inhibitor;Malignant Breast Neoplasm;Metastatic breast cancer;Metastatic/Recurrent;Modeling;mTOR Inhibitor;Mutate;Mutation;novel;Patients;Pharmaceutical Preparations;Phase;phase II trial;PIK3CA gene;PIK3CG gene;Positron-Emission Tomography;Pre-Clinical Model;precision medicine;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;Progesterone Receptors;Proteins;public health relevance;radiotracer;Receptor Cross-Talk;receptor expression;receptor function;Receptor Gene;Receptor Signaling;Recurrence;Resistance;resistance mechanism;response;response biomarker;Risk;RNA;Selective Estrogen Receptor Modulators;Signal Pathway;Specificity;standard of care;Tamoxifen;targeted treatment;transcriptome sequencing;treatment choice;treatment response;tumor;tumor xenograft;virtual;Woman;Women's trial;Xenograft Model

PROJECT_TITLE: FFNP-PET as a predictive biomarker of response to endocrine therapy approaches in advanced breast cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Sleep Research

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Chronic itch affects 13% of the population, has a profoundly negative impact on quality of life, and lacks FDA- approved treatments. A major obstacle that hinders treatment and the development of new therapeutics for chronic itch is the unavailability of an objective measure for quantifying itch, and the complete reliance on subjective measures such as patients’ self-assessment of their condition. In this proposal, we show that by analyzing the radio signals in the environment using machine learning we can infer patient scratching activity, and introduce a novel and objective measure for quantifying itch, and its impact on patients’ sleep and quality of life.

PI_NAMEs: KATABI, DINA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: actigraphy;Address;Adherence;Affect;Artificial Intelligence;awake;Behavior;Body part;Breathing;Child;chronic itch;chronic pain;Circadian Rhythms;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Data;Development;Devices;Disease;Disease Management;drug development;Environment;Expenditure;falls;FDA approved;Future;Gait;Head;Heart Rate;Home;Human;Impaired cognition;improved;invention;Life;Longitudinal Studies;Machine Learning;machine learning model;Measures;Methods;Monitor;Morbidity - disease rate;Motion;Neural Network Simulation;novel;novel therapeutics;Observational Study;Outcome Assessment;Patient Self-Report;Patients;Perception;Performance;Persons;Polysomnography;Population;Privacy;Property;prospective;Pruritus;Quality of life;Radio;Reaction;Research;Respiration;Self Assessment;sensor;sensor technology;Severities;Signal Transduction;skin irritation;Sleep;Sleep disturbances;sleep onset;sleep quality;Sleep Stages;Specificity;standard of care;success;Testing;Therapeutic;Time;Vulnerable Populations;wearable device;wireless electronic;wireless fidelity;wireless sensor;Wrist

PROJECT_TITLE: Developing an Objective and Quantifiable Measure of Itch Using Artificial Intelligence and Radio Signals

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: PROJECT NARRATIVE Improving and maintaining durable clinical responses to cancer immunotherapy requires a detailed understanding of dynamics between tumor and immune cells, particularly in the context of checkpoint blockade. I propose to elucidate the origin of immune cells that respond to checkpoint blockade as well as how genetic alterations in tumor cells affect immune surveillance in the context of immunotherapy. This work will provide novel insights into cellular mechanisms that underlie response to immunotherapy to help inform rational therapeutic strategies.

PI_NAMEs: YOST, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academic Training;Affect;anti-cancer research;Antigen-Presenting Cells;Biological Process;Biopsy;cancer cell;cancer immunotherapy;cancer therapy;cancer type;career;Cell Culture Techniques;Cells;Centromere;Clinical;Clonal Expansion;Clone Cells;Colorectal;Complex;Computer Analysis;CTLA4 blockade;Cytoplasm;Data;Dendritic Cells;design;DNA;DNA amplification;draining lymph node;efficacy evaluation;extrachromosomal DNA;Flow Cytometry;Genetic;Genomics;Goals;Human;Immune;immune activation;immune checkpoint blockade;Immune signaling;Immune system;Immunologic Surveillance;Immunotherapy;Impairment;improved;in vivo;in vivo Model;Infiltration;insight;Intrinsic factor;Link;Malignant Neoplasms;MC38;Modeling;mouse model;Mus;Mutation;neoplastic cell;novel;Oncogenes;Pathway interactions;patient subsets;Patients;PD-1 blockade;peripheral blood;permissiveness;Phase;Population;Postdoctoral Fellow;pre-doctoral;Process;Production;programmed cell death ligand 1;programmed cell death protein 1;receptor;recruit;Relapse;Research;Research Project Grants;response;RNA;Role;Scientist;secondary lymphoid organ;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;Source;Stimulator of Interferon Genes;System;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Tumor and Immune Cell Dynamics during Immunotherapy and Cancer Progression


ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The enclosure of the genome in the nucleus is essential for eukaryotic cell function; disruptions to nuclear integrity are associated with cancers and neurodegeneration. We propose to understand the molecular mechanisms that seal the nuclear membranes to surround and protect the genome. These efforts will inform both physiological and pathological processes that impact nuclear integrity.

PI_NAMEs: LUSK, CHARLES PATRICK (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Algorithmic Analysis;Anaphase;arm;Auxins;Biochemical;Biological Models;Carrier Proteins;Cell Nucleus;Cell Physiology;Cells;Complement;Complex;constriction;Coupled;Cryo-electron tomography;Custom;Cytoplasm;Data;daughter cell;Disease;Electron Microscopy;electron tomography;emerin;Endosomes;Ensure;Equilibrium;Eukaryotic Cell;Event;Experimental Models;experimental study;Family;Filament;Fission Yeast;flexibility;Fluorescence Resonance Energy Transfer;Genetic;Genome;Goals;Grant;Image Analysis;In Situ;in vivo;Individual;insight;Ions;Lateral;Lead;Light;light microscopy;Location;Malignant Neoplasms;man;Measurement;Measures;mechanical force;Mediating;Membrane;Membrane Proteins;Microscopy;Mitosis;Mitotic;Modeling;Molecular;Monitor;Morphology;Nerve Degeneration;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Pore Complex;Nucleoplasm;Organelles;Pathologic;Pathologic Processes;Pathway interactions;Physiological;Physiological Processes;Polymers;Proteins;Publishing;recruit;Resolution;response;Risk;Saccharomyces cerevisiae;Saccharomycetales;seal;segregation;sensor;Site;Sociology;Sorting;spatiotemporal;spindle pole body;Structure;success;System;Testing;Time;tomography;tool;Visualization;Work;Yeast Model System

PROJECT_TITLE: The mechanism of ESCRT-mediated surveillance of the nuclear envelope barrier

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: LA JOLLA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This application to renew an NIH funded (T32) training program focused on the epidemiology and prevention of cardiovascular disease is relevant to public health since heart disease and stroke remain the leading causes of morbidity and mortality in developed countries, and they are becoming significant public health problems in developing countries. Moreover, the causes of these diseases is multifactorial with lifestyle factors, including physical inactivity, poor diet and smoking, accounting for more than 50% of the burden of cardiovascular disease morbidity and mortality. Given this, the proposed training program will prepare pre- and post-doctoral fellows to become researchers who will explore the causes (both medical and behavioral) of cardiovascular disease so that effective prevention strategies can be developed and implemented.

PI_NAMEs: ALLISON, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TITLE: UCSD Integrated Cardiovascular Epidemiology Fellowship

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Mental Health;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE Patients with hematologic malignancies who are recipients of allogeneic stem cell transplantation have a high burden of psychological distress that undermines their psychological well-being, coping, health behaviors, quality of life (QOL), and overall recovery. This proposed research project aims to develop and test a novel 9- week positive psychological intervention for allogeneic transplant patients (PATH) that specifically targets psychological, behavioral, and QOL outcomes during the post-transplantation recovery period. The PATH intervention has the potential to greatly impact health outcomes and recovery in this vulnerable cancer population.

PI_NAMEs: AMONOO, HERMIONI L. (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;Allogenic;Anxiety;Area;arm;Award;Behavior Therapy;Behavioral;behavioral outcome;Biometry;Buffers;Cardiac;career;Clinical;clinical practice;clinical training;Clinical Trials;Clinical Trials Design;coping;curative treatments;Data;Dedications;Dissemination and Implementation;Distress;Doctor of Philosophy;Effectiveness;emotional experience;Event;evidence base;exercise intervention;experience;feasibility testing;Feedback;functional outcomes;Funding;Goals;gratitude;Health;Health behavior;Health Care Costs;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Homologous Transplantation;Hospitalization;implementation barriers;implementation facilitators;implementation science;improved;Individual;Intervention;intervention refinement;Intervention Studies;Intervention Trial;Interview;Letters;Life;long term recovery;Malignant Neoplasms;Medical;medical complication;medication compliance;Mental Depression;Mental Health;Mental health promotion;Mentors;Mentorship;Methods;Modeling;Moods;Motivation;Nature;novel;Oncology;optimism;Outcome;Participant;Patients;Personal Satisfaction;Phase;phase 1 study;phase 2 study;Physical activity;Physical Function;physical symptom;pilot trial;Population;positive emotional state;post-transplant;primary outcome;Principal Investigator;Process;programs;prospective;Psychiatry;psychologic;psychological distress;psychological outcomes;Psychology;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Reporting;Research;Research Personnel;Research Project Grants;Review Literature;sociodemographic variables;Stem cell transplant;Structure;Supportive care;Survivors;symposium;Symptoms;Telephone;Testing;theories;therapy development;Training;Transplant Recipients;transplant survivor;Transplantation;treatment as usual;United States;United States National Institutes of Health;Well in self;Work;Writing

PROJECT_TITLE: A Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Neurosciences;Pain Research;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Patients with oral cavity cancers may experience extreme pain, which is induced by mediators from the cancers acting on local nerve endings. The proposed studies investigate the potential of a gene, artemin that is highly expressed in the cancers to both promote cancer and induce pain. A role for artemin in oral cancer and oral cancer pain has not been appreciated previously and a better understanding of its contribution to oral cancer and pain offers the possibility of developing new approaches to treating cancer and alleviating cancer pain through blocking function of artemin.

PI_NAMEs: ALBERTSON, DONNA G (contact);SCHMIDT, BRIAN L

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Agonist;Animal Model;Attenuated;attenuation;autocrine;Behavior;Behavioral;Blocking Antibodies;cancer pain;Cancer Pain Management;Cancer Patient;cancer therapy;carcinogenesis;Cations;Cell Line;Chronic;Clinical Trials;combinatorial;Cultured Cells;Data;Dose;effective therapy;Endothelin;Endothelin-1;experience;Foundations;Future;Genes;Genomics;glial cell-line derived neurotrophic factor;Goals;Growth;Human;Hypersensitivity;Immunohistochemistry;improved;In Vitro;Incidence;Individual;individualized medicine;Induced Neurons;innovation;Invaded;malignant mouth neoplasm;Malignant Neoplasms;Measurable;Measures;Mechanics;Mediator;member;Modeling;mouse model;Mus;Nature;Neoplasm Metastasis;Nerve Endings;Nerve Growth Factors;neural;Neurons;neutralizing antibody;Nitroquinolines;Nociception;Nociceptors;Non-Malignant;novel strategies;Oncogenes;Oncogenic;Opioid;Oral;oral pain;oral tissue;overexpression;Oxides;Pain;paracrine;Pathway interactions;Patients;Phenotype;precision medicine;Protein Family;Proteins;Quality of life;Questionnaires;receptor;Reporting;Research;Role;Sampling;side effect;Specimen;spinal nerve posterior root;Structure of trigeminal ganglion;synergism;Testing;transcriptome;treatment response;TRPV1 gene;tumor microenvironment;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Artemin overexpression in oral cancer pain and carcinogenesis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention;Skin Cancer

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative In partnership with Vidrio Technologies and Tufts University, we develop a fast, large area multiphoton exoscope (FLAME) for clinicians, as a powerful imaging tool for non-invasive, real-time quantitative assessment at the bedside that would not require specialized training. We integrate safety features, establish imaging stability to physiological motion and then test the performance of this device by evaluating its ability to provide in-vivo quantitative optical endpoints with sufficiently high predictive power to reliably distinguish benign from early melanoma lesions. Completion of these studies will establish the practical utility and value of FLAME as a non-invasive bedside tool for clinical skin imaging.

PI_NAMEs: BALU, MIHAELA  (contact);KELLY, KRISTEN M

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adoption;Advanced Development;Affect;Algorithms;application programming interface;Area;Benign;Benign Melanocytic Nevus;Biological Markers;Biopsy;Cellular Morphology;Clinical;clinical imaging;Clinical Research;Collaborations;Collagen;Computer software;Connective Tissue;cost;Cutaneous Melanoma;data acquisition;Data Analyses;data standards;deep learning;Dermatology;Dermoscopy;Devices;Diagnosis;Discriminant Analysis;Disease;Early Diagnosis;Elastin Fiber;Electronics;Environment;ex vivo imaging;Fluorescence;Generations;Germany;Histopathology;Image;Image Analysis;imaging detection;Imaging Device;imaging platform;imaging study;Imaging Techniques;improved;in vivo;in vivo imaging;indexing;industry partner;innovation;instrument;Interobserver Variability;Keratin;Label;Lasers;Lesion;Lesion by Stage;Maps;Mechanics;Medical Care Costs;Melanins;melanocyte;Melanocytic Neoplasm;Melanoma;metabolic imaging;Metabolism;Methods;Microscope;Microscopic;Modality;Molecular;Morphology;Motion;multi-photon;multidisciplinary;multiphoton microscopy;Nature;Negative Finding;non-invasive imaging;optical imaging;Optics;Pathology;Patients;Performance;performance tests;Physicians;Physiological;portability;prototype;real-time images;Reporting;Research Personnel;Resolution;restoration;Safety;Scanning;second harmonic;Side;Signal Transduction;Skin;Skin Tissue;software development;Specific qualifier value;Speed;standard of care;Standardization;Structure;submicron;Superficial Lesion;System;Technology;temporal measurement;Testing;Time;Tissues;tool;Training;translational study;Treatment Cost;two-dimensional;two-photon;United States;Universities;Validation

PROJECT_TITLE: Fast, large area, multiphoton exoscope (FLAME) for improving early detection of melanoma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The explosive increase in the prevalence of Alzheimer’s disease and other neurodegenerative disorders in the aging population is one of the great medical challenges of the twenty-first century. The Training Program in the Molecular Biology of Neurodegeneration and Alzheimer’s disease provides a framework within which the best training of future researchers devoted to curing neurodegenerative diseases can take place. The Program capitalizes on the extensive and concentrated effort in this area taking place at Harvard Medical School and its affiliated hospitals, and has succeeded in training some of the leading research scientists working at the frontiers of neurodegenerative disease research.

PI_NAMEs: YANKNER, BRUCE A (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Alzheimer's Disease;Molecular Biology;Nerve Degeneration;Training

PROJECT_TITLE: Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

PHR: Project Narrative Difficulties with prospective memory, such as remembering to take medications, represent a signature decline in mild dementia, worsen quality of life and independence, and add burden to care partners. In this randomized controlled trial, individuals with mild cognitive impairment and mild dementia will train to use either a smartphone-based or paper-based memory strategy to compensate for daily prospective memory challenges. This work will help preserve independent functioning in persons with cognitive impairment and reduce burden on families impacted by dementia.

PI_NAMEs: BENGE, JARED F;SCULLIN, MICHAEL K (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: acceptability and feasibility;active control;Address;Adherence;aging and technology;Alzheimer's disease related dementia;Alzheimer's disease risk;Anterior;Appointment;Behavior Therapy;Calendar;care recipients;caregiving;Caring;Catchment Area;Cellular Phone;Clinic;Clinical;Cognitive;cognitive change;cognitive training;Communities;Compensation;daily functioning;Data;Dementia;digital;Disadvantaged;disadvantaged background;Disparity population;efficacy testing;Enrollment;Ensure;Equity;Ethnic Population;Event;Family;family burden;follow-up;Foundations;Friends;Future;Goals;Health Personnel;Hippocampus;Impaired cognition;Impairment;improved;Individual;Inequity;informant;Intervention;Intervention Studies;Interview;Lead;loved ones;low socioeconomic status;medication compliance;Medicine;member;Memory;Memory impairment;mild cognitive impairment;older adult;Outcome;Paper;Participant;patient oriented;Patient Selection;Patients;Performance;Persons;Pharmaceutical Preparations;Pilot Projects;pilot trial;Population;Positioning Attribute;Prefrontal Cortex;preservation;Procedures;prospective memory;Quality of life;racial population;Randomized;Randomized, Controlled Trials;recruit;Reminder Systems;Reporting;Research;Rural;Sample Size;Sampling;Self Efficacy;Site;social;socioeconomics;Stress;success;Support System;System;Technology;technology intervention;Testing;Time;Training;Underrepresented Populations;Work

PROJECT_TITLE: Smartphone-Based Solutions for Prospective Memory in Mild Cognitive Impairment and Dementia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: NARRATIVE The overarching goal of this application is to translate novel risk mechanisms into tools for cancer interception. By defining the risk of developing MM precursors at the genomic level and not just basing risk on race and familial history, we can more precisely identify the specific populations at risk and develop focused strategies of early interception.

PI_NAMEs: GHOBRIAL, IRENE M. (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: African American;African American population;Age;Aging;biobank;Biological;Black race;cancer risk;carcinogenesis;case control;Chronology;cohort;Cohort Studies;Data;data integration;Development;Diagnosis;Disease;DNA;Early Diagnosis;Elderly;Family history of;Frequencies;gammopathy;Genetic;genome sequencing;genomic signature;Genomics;Germ Lines;Germ-Line Mutation;Goals;Health;Hematologic Neoplasms;Hematopoietic Neoplasms;high risk;high risk population;Immune;Immune system;improved;MALDI-TOF Mass Spectrometry;Malignant Neoplasms;Measures;Molecular;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;Multiple Myeloma;novel;Organ;Outcome;Participant;Patient Self-Report;Patients;Peripheral Blood Mononuclear Cell;Persons;Population;Populations at Risk;Prevalence;Prevention;Process;Progression-Free Survivals;Prospective, cohort study;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Race;racial difference;Recording of previous events;Risk;Risk Factors;risk stratification;Role;Sampling;screening;Serum;sex;Source;T cell receptor repertoire sequencing;T-cell diversity;T-Lymphocyte;Therapeutic Intervention;Tissue Banks;Tissues;tool;Translating;whole genome

PROJECT_TITLE: Molecular prediction of myeloma in African Americans


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: OTTAWA

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: OTTAWA HOSPITAL RESEARCH INSTITUTE

ORG_STATE: ON

ORG_ZIPCODE: K1Y 4E9

PHR: Project Narrative We have identified a gene signature together with unique cell-surface markers that allow the purification of a subset of satellite cells in skeletal muscle that are long-term self-renewing stem cells that we term satellite stem cells. We propose to conduct experiments to establish their hierarchal relationships with their derivatives, and to investigate the molecular regulation of their identify and function. These studies will facilitate rapid advances in our understanding of the molecular mechanisms that regulate satellite stem cell homeostasis in human muscle wasting diseases and in aging.

PI_NAMEs: RUDNICKI, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Aging;Alleles;Biological Assay;Biology;Biopsy;Brown Fat;CD36 gene;Cell Compartmentation;Cell Differentiation process;Cell division;Cell Lineage;Cell Separation;Cell surface;Cells;Data;Development;differential expression;Disease;Duchenne muscular dystrophy;Engraftment;Exhibits;experimental study;Expression Profiling;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic analysis;Genetic Markers;genetic signature;Growth;Health;Heterogeneity;Human;Immune;Informal Social Control;Injury;innovation;insight;interest;Kinetics;Knowledge;Label;loss of function mutation;mdx mouse;Methodology;Molecular;Molecular Analysis;Molecular Genetics;mouse model;Mus;Muscle;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Muscular Atrophy;Natural regeneration;Neuromuscular Diseases;novel;Population;progenitor;Proliferating;Property;prospective;reconstruction;Regulation;Regulator Genes;Resolution;self-renewal;single cell analysis;single-cell RNA sequencing;Skeletal Muscle;Skeletal Muscle Satellite Cells;Specific qualifier value;stem cell biology;stem cell function;stem cell homeostasis;stem cell population;stem cells;Stromal Cell-Derived Factor 1;Technology;Testing;Therapeutic Intervention;transcriptome sequencing;transcriptomics;Translating;Transplantation;Wasting Syndrome

PROJECT_TITLE: Genetic Regulation of Skeletal Muscle Repair

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]