FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Pediatric;Telehealth

ORG_CITY: OAKLAND

ORG_NAME: APPA HEALTH INC

PHR: PROJECT NARRATIVE. This partnership between Appa Health and the University of Washington will conduct a randomized controlled trial on the effectiveness and costs of a near-peer mentoring program coupled with videos on cognitive-behavioral therapy skills (Full Appa) as compared to videos alone (Appa Light) and a wait list control group. The study will include a pilot trial to optimize study procedures followed by a fully-powered effectiveness trial, and will collect experience and outcome data on adolescents over 12 weeks of the program. The results of this study will inform marketing and commercialization of Full Appa and possible development of Appa Light as a new product version.

PI_NAMEs: KAUFMAN, MICHELLE R.;MILLER, ROBERT JOSEPH (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Accountability;Address;Adolescent;Adolescent and Young Adult;adolescent mental health;Advertising;Affect;Age Years;aged;Anxiety;anxiety symptoms;arm;Behavioral;caregiver strain;Caregivers;Caring;Cellular Phone;child depression;Clinical;Clinical effectiveness;Cognitive;Cognitive Therapy;commercialization;Computers;Control Groups;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Coupled;Data;depressive symptoms;design;Development;diadenosine pyrophosphate;digital;digital delivery;digital mental health;digital platform;digital tool;Drops;Early Intervention;Education;Educational process of instructing;Effectiveness;effectiveness research;effectiveness study;effectiveness trial;Elements;Employment;Ensure;Equity;evidence base;experience;Financial Hardship;Friends;Funding;Goals;Health;Health Personnel;implementation strategy;improved;innovation;Internet;Intervention;Knowledge;Learning;Light;Lived experience;Marketing;Meaning and purpose;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;Outcome;Participant;participant retention;peer coaching;peer support;Personal Satisfaction;Persons;Phase;physical conditioning;Pilot Projects;pilot test;pilot trial;premature;Prevention;Prevention strategy;Procedures;programs;psychoeducation;psychosocial;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;Risk;Sales;Sampling;Schools;Science;self esteem;self help;Services;severe mental illness;Silicon;skills;Small Business Innovation Research Grant;social relationships;Structure;Supervision;symptomatic improvement;Symptoms;Teenagers;Theory of Change;Therapeutic;TikTok;tool;Training;Treatment Efficacy;United States;Universities;Use Effectiveness;video delivery;Waiting Lists;Washington;young adult;Youth

PROJECT_TITLE: Digital Delivery of Evidence-Based Mental Health Content and Mentoring to Adolescents


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This training program aims to engage and train the next generation of diverse heart, lung, blood/vascular researchers. CHP2-SRIP students will attend didactic lectures, lab courses and hands on lab experience at the hands of world-class researchers in one of the most prolific and exciting research institutions in the country. We will attempt to train between 13-15 students per year for the duration of the grant.

PI_NAMEs: CELEDON, JUAN CARLOS (contact);SIMS-LUCAS, SUNDER

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Affect;African American;African American population;Anatomy;Asthma;Basic Science;Black Populations;Blood;Blood Vessels;Cardiology;career;Caring;Child;Childhood;Clinical Research;Country;COVID-19;Critical Care;Developmental Biology;Disease;diversity and inclusion;Doctor of Philosophy;Education;Educational Activities;effective therapy;Ethnic Population;Exposure to;Faculty;faculty research;follow-up;Funding;Future;Goals;Grant;Hand;health disparity;Heart;Heart Diseases;Hematological Disease;Hematology;Hour;Infrastructure;innovation;Institution;interest;International;Internships;Journals;Laboratories;laboratory experience;Latinx;lectures;Lung;Lung Diseases;Medical Research;medical specialties;Medicine;member;Mentors;Mentorship;Methods;minority children;minority trainee;minority undergraduate;Multimedia;National Heart, Lung, and Blood Institute;Native Americans;next generation;Oncology;Oral;organ growth;Paper;Pathology;patient oriented;patient oriented research;Pediatric cardiology;pediatric department;Pediatric Hospitals;Pediatric Research;Pediatrics;Physicians;Physiology;Population Heterogeneity;Positioning Attribute;programs;Public Health Schools;Puerto Rican;Puerto Rico;Pulmonology;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;Science;Scientist;Sickle Cell Anemia;student mentoring;Students;summer program;summer research;symposium;Teacher Professional Development;Training;Training Programs;Translational Research;Travel;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Universities;university student;Vascular Diseases;web site;Work

PROJECT_TITLE: The Children’s Hospital of Pittsburgh -Cardiology, Hematology and Pulmonology Summer Research Internship Program (CHP2-SRIP)


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE We propose to investigate the mechanisms of action of the CARM1 methyltransferase in controlling small cell lung cancer pathogenesis via methylation of NFIB and therapeutic validation of small molecule inhibitors of CARM1 using pre-clinical cancer models.

PI_NAMEs: BEDFORD, MARK T.;MAZUR, PAWEL K. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;arginine methyltransferase;ATAC-seq;C-terminal;Cancer Model;Cancer Patient;Cell Separation;coactivator-associated arginine methyltransferase 1;Collaborations;Complex;conditional knockout;Crystallography;Development;Epigenetic Process;epigenetic profiling;Evolution;Excision;experimental study;extend lifespan;Family;FDA approved;Future;Genetic Transcription;Genetically Engineered Mouse;Grant;human disease;in vivo;inhibitor;Knock-in Mouse;Knowledge;Life Expectancy;lung cancer cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Methylation;Methyltransferase;model development;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Neoplasm Metastasis;neoplastic cell;NFIB gene;novel;Oncogenic;overexpression;Pathogenesis;Pathway interactions;patient derived xenograft model;pre-clinical;preclinical study;programs;Property;protein complex;Rationalization;Reader;recombinase;recruit;Reporting;Research;response;Role;Signal Transduction;single-cell RNA sequencing;Site;small cell lung carcinoma;small molecule inhibitor;targeted treatment;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcription factor;transcriptome sequencing;Translations;tumor heterogeneity;tumor progression;Tumor Promotion;Validation

PROJECT_TITLE: Mechanisms of action and therapeutic targeting of the CARM1-NFIB axis in small cell lung cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurosciences;Nutrition;Obesity;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: NARRATIVE Patients with sleep apnea are at increased risk of developing cardiovascular disease – with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. The proposed project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.

PI_NAMEs: LIMBERG, JACQUELINE K (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acute;Adrenergic Agents;Adrenergic alpha-Agonists;Adrenergic Antagonists;Adrenergic beta-Agonists;Adult;adult obesity;alpha-adrenergic receptor;Area;Attenuated;beta-adrenergic receptor;Blood flow;Blood Pressure;blood pressure elevation;Blood Vessels;Body mass index;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Catecholamines;Chronic;Cohort Studies;constriction;Data;Development;Dexmedetomidine;Disproportionately impacts women;Endothelial Cells;epidemiologic data;ESR1 gene;Estrogens;Exhibits;Exposure to;Failure;falls;Female;Forearm;Functional disorder;Goals;high risk;Human;Hypertension;Hypoxemia;Hypoxia;Impairment;improved;ineffective therapies;Infusion procedures;Intervention;Intra-Arterial Infusions;Isoproterenol;Knowledge;Measures;Mediating;men;mortality;Muscle;Nerve;Neurotransmitters;neurovascular;Nitric Oxide;Norepinephrine;normoxia;novel therapeutics;Obesity;Overweight;Oxygen;Pathogenesis;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;pharmacologic;Phentolamine;Phenylephrine;Physiological;Plasma;Population;pre-clinical;Premenopause;preservation;Prevalence;prevent;Propranolol;Receptor Activation;receptor sensitivity;Regulation;Relaxation;Research;Resistance;response;Risk;Risk Factors;Role;sex;Sex Differences;sex disparity;Skeletal Muscle;Sleep Apnea Syndromes;Stress;Sympathetic Nervous System;Testing;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Weight;Woman;women patients;women versus men;Work;young man;young woman

PROJECT_TITLE: Sex disparities in hypoxic sympatholysis and impact of obesity

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Primary Health Care;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research is relevant to public health because more than 1.5 million older adults undergo emergency intra-abdominal surgery and more than 25% develop delirium post-operatively. Interventions that can enhance the recovery of these patients can lead to a decrease in long-term disability and dependence of these patients. Thus, the proposed research is relevant to the NIH’s mission to develop new knowledge that will help to reduce the burdens associated with human disability.

PI_NAMEs: BOUSTANI, MALAZ ;ZARZAUR, BEN L (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adhesions;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;anxiety symptoms;biopsychosocial;Caring;Chronic;Chronic Care;Chronic Disease;Cognition;Cognitive;cognitive recovery;Colectomy;collaborative care;Complex;Conscious;Country;Cytolysis;Delirium;Dementia;Dependence;disability;efficacy evaluation;emergency settings;Emergency Situation;evidence base;Excision;experience;feasibility testing;frailty;functional decline;functional independence;functional loss;Generalized Anxiety Disorder;Goals;Health;health care service utilization;Health Services;high risk;Hospitalization;Hospitals;Human;human old age (65+);Impaired cognition;improved;indexing;Indiana;innovation;Intervention;Intra-abdominal;Knowledge;Laparotomy;Lead;Life Expectancy;Long term disability;Managed Care;Measures;Medical;medical schools;medical specialties;meetings;Mental Depression;Mission;Modeling;mood symptom;Morbidity - disease rate;neuropsychiatry;Neuropsychology;older adult;operation;Operative Surgical Procedures;Outcome Study;patient population;Patients;Peptic Ulcer;personalized care;Physical Performance;Physicians;Positioning Attribute;postoperative delirium;Postoperative Period;prevent;Primary Care;programs;Psyche structure;psychologic;Public Health;Quality of Care;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;repaired;Research;Research Personnel;Risk;Small Intestines;Survivors;Syndrome;telehealth;Time;treatment as usual;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: Emergency General Surgery Delirium Recovery Model: A Collaborative Care Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The proposed research is relevant to public health because these studies will improve our understanding of the biology-materials interfaces and may lead to new design principles for biomaterials engineered to elicit robust levels of immune responses, thereby addressing current technical limitations in vaccine technologies.

PI_NAMEs: CASTRO, MARIA G;MOON, JAMES J. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 19q;Address;Adjuvant;Adult Glioma;alpha ketoglutarate;anti-PD-L1;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;ATRX gene;Benchmarking;Biocompatible Materials;Biology;Blood;Bone Marrow;cancer immunotherapy;Cancer Patient;cancer therapy;Cell Differentiation process;Cells;Classification;Clinical;cytotoxic;design;draining lymph node;Engineering;Epitopes;Exhibits;gain of function mutation;Genetic;Genetic Engineering;Genomic DNA;Glioma;Goals;High Density Lipoproteins;Human;human disease;Immune;immune checkpoint;immune checkpoint blockade;immune function;Immune response;Immunity;Immunocompetent;Immunologic Memory;Immunologic Stimulation;Immunologics;Immunotherapeutic agent;Immunotherapy;Implant;improved;in vivo;Intracranial Neoplasms;Isocitrate Dehydrogenase;Knowledge;Lesion;Lipids;Lymphatic;Lymphoid Tissue;Malignant neoplasm of brain;Mediating;Modeling;Molecular;Mus;mutant;Mutation;nanodisc technology;nanodisk;nanolipoprotein particles;nanomaterials;Nanotechnology;nanovaccine;nerve stem cell;Neurosphere;nondeletion type alpha-thalassemia/mental retardation syndrome;novel;novel strategies;novel therapeutic intervention;novel vaccines;Operative Surgical Procedures;Patients;personalized immunotherapy;Physiological;Production;Prognosis;promoter;Public Health;Radiation;Recurrence;Recurrent tumor;Research;response;Role;Serum;Sleeping Beauty;Solid Neoplasm;Spleen;standard of care;Subgroup;success;T cell response;T memory cell;T-Lymphocyte;Technology;Testing;Therapeutic;TP53 gene;Transplantation;Transposase;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor-immune system interactions;uptake;Vaccination;Vaccine Antigen;vaccine delivery;vaccine platform;Vaccines;virtual;Work

PROJECT_TITLE: Novel nano-vaccine technology for inducing immunity against gliomas

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE The National Cancer Institute launched the Cancer Center Cessation Initiative in 2017 to provide financial and experiential assistance for the development of dedicated tobacco treatment programs across 52 NCI- Designated Cancer Centers. The objectives of this proposal are to evaluate the sustainability of tobacco treatment programs in the initiative and their intended health benefits and to develop a toolkit of sustainment strategies.

PI_NAMEs: SALLOUM, RAMZI GEORGE (contact);WARREN, GRAHAM W.

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Address;Adoption;Advocate;Assessment tool;cancer care;Cancer Center;cancer diagnosis;Cancer Survivor;Clinical;Collaborations;Communities;Dedications;Development;Effectiveness;effectiveness testing;evidence base;Evidence based intervention;Evidence based program;Foundations;Funding;Goals;Health;Health Benefit;Health system;Healthcare Systems;implementation science;implementation strategy;improved;improved outcome;innovation;Interview;Investments;Knowledge;Maintenance;Maps;Measures;Methods;model generalizability;Modification;National Cancer Institute;Oncology;Outcome;Outcome Assessment;Patient Care;patient screening;Patients;Phase;Program Sustainability;programs;Provider;public health relevance;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Sampling;Smoking;smoking cessation;Specific qualifier value;standard of care;Surgeon;sustainability framework;Testing;Time;Tobacco;tobacco abstinence;tobacco screening;Tobacco use;Tobacco Use Cessation;treatment program;treatment services;user centered design

PROJECT_TITLE: Sustainability of Tobacco Cessation Programs at NCI-Designated Cancer Centers

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative This T90/R90 postdoctoral and DMD/PhD training program is intended to provide research training and research education experiences to US and non-US citizens, positioning them as investigators who can successfully compete for research funds in areas of oral health research, clearly and effectively communicate their thoughts both orally and on paper, recognize the value of collaborative and multidisciplinary research interactions, lead and inspire others to accomplish mutual research objectives, know how to translate their findings to practice, be ethical in their decision-making processes, harmonious in their relationships with other scientists, and who know how to acquire new skills as their careers advance.

PI_NAMEs: VAN DYKE, THOMAS ELLIOTT (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Advisory Committees;Applications Grants;Appointment;career;Clinical;Committee Members;Communication;craniofacial;Dental Schools;Dentists;Disease;Doctor of Philosophy;Educational process of instructing;Educational workshop;Elements;Environment;experience;Feedback;Funding;Future;Grant;Grant Review;Health;High School Student;Individual;Interdisciplinary Study;Investigation;medical schools;Medicine;Mentors;Methods;Nevada;North Carolina;Oral;Oral health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preparation;Program Reviews;programs;recruit;Reproducibility;Research;research and development;Research Personnel;Research Training;responsible research conduct;Scientist;skills;summer research;Time;Training;Training Programs;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Forsyth Training in Oral Health Research


NIH_SPENDING_CATS: Cancer

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: A fuller mechanistic understanding of cancer biology will lead to progressively more effective cancer diagnosis, therapy, and prevention. This application continues support for the Training Program in Cancer Biology launched in 2011 in order to train the next generation of basic, translational and clinical researchers at the University of Maryland Baltimore’s Marlene and Stewart Greenebaum Comprehensive Cancer Center. A strength of this program is the training of exceptionally talented physician-scientists and PhD scientists to translate between the laboratory bench and the bedsides of patients with cancer.

PI_NAMEs: ANTALIS, TONI M (contact);CIVIN, CURT I

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Grant;Training

PROJECT_TITLE: Training Grant in Cancer Biology


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lung Cancer;Patient Safety;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Studying interventions for smokers prior to cancer surgery has the potential to improve quit rates as well as surgical outcomes in this population. We hypothesize that this pre-surgical intervention, combining smoking cessation counseling and nicotine replacement therapy (NRT) with contingency management, will promote high rates of smoking cessation and will be associated with better surgical outcomes.

PI_NAMEs: TOLL, BENJAMIN ANDREW (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Adjuvant;Advocate;American Association of Cancer Research;American Society of Clinical Oncology;Behavior Therapy;Biochemical;Breath Tests;cancer care;cancer diagnosis;Cancer Intervention;Cancer Patient;cancer site;cancer surgery;cancer therapy;Carbon Monoxide;Clinical;clinical care;Clinical Trials;contingency management;Cost Analysis;cost effective;Counseling;Data;Day Surgery;design;Diagnosis;effective intervention;effective therapy;effectiveness evaluation;Effectiveness of Interventions;financial incentive;follow-up;Funding;Health;high risk;improved;Incidence;Infrastructure;Intervention;Intervention Studies;Life;Link;long term abstinence;Malignant Neoplasms;medical complication;Monitor;mortality;National Comprehensive Cancer Network;nicotine replacement;novel;Operative Surgical Procedures;Participant;Patients;payment;Perioperative;Pilot Projects;Population;Prevalence;Protocols documentation;Randomized;randomized, clinical trials;Recommendation;Relapse;Research;Research Design;respiratory;Risk;Second Primary Cancers;Site;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking intervention;Smoking Status;standard care;Subgroup;surgery outcome;Surgical complication;surgical risk;Testing;Time;tobacco abstinence;Tobacco use;Tobacco Use Cessation;tool;treatment response;Treatment-related toxicity;United States National Institutes of Health;Work;wound healing;Wound Infection

PROJECT_TITLE: Contingency Management to Promote Smoking Abstinence in Cancer Patients

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The goal of this project is to provide highly focused and advanced training in the development, function and dysfunction of the mammalian cerebral cortex at Yale University. Twenty-seven (27) faculty from eleven (11) basic and clinical departments at both Yale School of Medicine and Yale College are mentors in this multidisciplinary program for predoctoral trainees. Training includes focused coursework, aggressive mentorship through advisory committees, intensive research apprenticeship, structured seminar programs, career skills development, extensive critical evaluation of trainees and the training program, and opportunities for laboratory and departmental presentations of research progress.

PI_NAMEs: CARDIN, JESSICA A (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurobiology;System

PROJECT_TITLE: Neurobiology of Cortical Systems


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Positron emission tomography (PET) is a widely used imaging modality for Alzheimer's disease. This project aims to develop advanced image reconstruction methods to improve Tau PET image quality. Success of this project can enable better diagnosis and progression/treatment tracking of Alzheimer's disease.

PI_NAMEs: GONG, KUANG  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Address;Adoption;Aducanumab;Affinity;Alzheimer's Disease;Alzheimer's disease diagnosis;Applications Grants;attenuation;Behavior Disorders;Binding;Biological Markers;Brain Injuries;Brain region;Cerebrovascular Circulation;Clinical;Clinical Trials;Cognitive;Data;Data Set;deep learning;denoising;density;Deposition;Development;Diagnosis;drug development;Early Diagnosis;Early treatment;entorhinal cortex;Family;FDA approved;Generations;Goals;Hippocampus;Hour;human old age (65+);Image;image reconstruction;imaging biomarker;imaging modality;Impaired cognition;improved;in vivo;kinetic model;Kinetics;Label;Longitudinal Studies;Measures;Memory Loss;Meninges;Methods;Monitor;Nature;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurotransmitters;Noise;Outcome;pain relief;parametric imaging;Patients;Pattern;Performance;Perfusion;Persons;Physics;Population;Positron-Emission Tomography;pre-clinical;Protocols documentation;reconstruction;Recovery;Resolution;Sample Size;Scanning;Scheme;Signal Transduction;Staging;success;Synapses;System;tau aggregation;tau Proteins;Testing;Thinness;Time;Tracer;Training;training data;United States;Update;uptake;β-amyloid burden

PROJECT_TITLE: Optimization of Tau PET Imaging for Alzheimer's Disease through Deep Learning-Based Image Reconstruction

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: TUSCALOOSA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Narrative Type III-A CRISPR-Cas systems are RNA-protein complexes used by prokaryotes for adaptive immunity to foreign nucleic acids. A robust understanding of the structures and nucleic acid interference mechanisms of Type III-A CRISPR-Cas will aid in understanding their role in mobile genetic element transfer among bacteria, a common mode of spreading antibiotic resistance genes and facilitate new biotechnologies. We propose integrated biochemistry and biophysics experiments to elucidate the structure and mechanism of Type III-A CRISPR-Cas.

PI_NAMEs: DUNKLE, JACK ALBERT (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Antibiotic Resistance;Bacteria;Binding;Biochemistry;Biophysics;Biotechnology;Clustered Regularly Interspaced Short Palindromic Repeats;Cryoelectron Microscopy;Detection;Diagnostic;DNA;ds-DNA;experimental study;genetic element;Location;Mobile Genetic Elements;Multiprotein Complexes;nuclease;Nucleic Acids;Play;point of care;Prokaryotic Cells;protein complex;Proteins;Regulation;Research;resistance gene;response;RNA;RNA Binding;RNA Degradation;RNA Viruses;Role;Signal Transduction;Specificity;Structural Models;Structure;System;Testing;Transcript

PROJECT_TITLE: Determining the specificity and regulation of Type III CRISPR-Cas interference

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: This Regional and National Resource will provide cutting-edge electron-spin resonance spectroscopy capabilities for biomedical researchers engaged in NIH-sponsored projects aimed at understanding and combatting diseases and ailments (e.g., AIDS, allergies and inflammations, ALS, Alzheimer's, bacterial infection, cancer, cardiac disease, depressive disorders and schizophrenia, Ebola virus infections, eye disorders, infertility, neurological disorders, Parkinson's, and SARS-Cov-2). Through service and collaboration, both experimental and computational techniques will reveal disease mechanism through the study of macromolecular structure, dynamics and function.

PI_NAMEs: CRANE, BRIAN R;FREED, JACK H (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Advertisements;Alzheimer's Disease;analysis pipeline;Bacterial Infections;base;biological systems;Biomedical Research;biomedical resource;Collaborations;Collection;Communities;Complex;Computational Technique;Computer Analysis;Computer software;computerized data processing;computing resources;Custom;Data;Data Analyses;Data Collection;Dedications;Depressive disorder;Development;Disease;Ebola virus;Education and Outreach;Educational workshop;Electron Nuclear Double Resonance;Electron Spin Resonance Spectroscopy;Equipment;experience;experimental study;Eye diseases;Frequencies;frontier;Funding;Future;Grant;Heart Diseases;Home;Human Resources;Hypersensitivity;improved;Infertility;innovation;instrument;instrumentation;International;Journals;Label;Laboratories;Leadership;Learning;lectures;macromolecule;Malignant Neoplasms;meetings;Methodology;Methods;Mission;Modernization;Molecular;Molecular Biology;molecular dynamics;Molecular Structure;Motion;nanosecond;Nervous System Disorder;Newsletter;Noise;novel;online resource;operation;outreach;Paper;Parkinson Disease;Physiologic pulse;Postdoctoral Fellow;Procedures;Process;programs;protein complex;Protein Dynamics;protein structure;Proteins;Publishing;R24;Recovery;Reporting;Research Personnel;Resources;RNA;Role;Running;Sampling;Sampling Studies;Schedule;Scheme;Schizophrenia;Scientist;Seasons;Series;Services;signal processing;Signal Transduction;Site;Societies;Special Equipment;Strategic Planning;Structure;Students;success;System;Techniques;Technology;Temperature;Tertiary Protein Structure;Time;Training;Training and Education;United States National Institutes of Health;virtual;Virus Diseases;Visit

PROJECT_TITLE: National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)


ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The burden of cancer in the United States and across the globe is substantial with an estimated number of cancer cases and deaths in the US in 2019 of 1,762,450 and 606,880 individuals respectively. At the same time cancer is at the vanguard in the development of “precision” approaches using a myriad of advances from the laboratory to advance prevention, screening, diagnosis, treatment, and survivorship strategies and disseminate them broadly and equitably, and this requires trained scientists, especially physician-scientists, to drive the advances in biologically-driven, evidence-based care. The aim of this research training program is to recruit and prepare highly qualified physicians from diverse backgrounds for a research-intensive career in medical or gynecological oncology by developing research skills in cancer biology, diagnosis, prevention, therapy, and outcomes.

PI_NAMEs: DAVIDSON, NANCY ELLEN (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: TRAINING IN CANCER BIOLOGY AND TRANSPLANTATION

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Medical devices are common in healthcare, but often lead to morbidity in the form of device-associated thrombosis. Current strategies to prevent and treat device associated thrombosis are often ineffective and universally cause bleeding. There is an unmet need to develop safer and more effective therapies for device- associated thrombosis. Herein we will characterize novel druggable molecular interactions between the blood microenvironment and the surface of medical devices that contribute to inflammation and increased blood coagulation.

PI_NAMEs: SHATZEL, JOSEPH JAMES (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Anticoagulants;Anticoagulation;Antiplatelet Drugs;Benefits and Risks;Binding;Blood;Blood coagulation;Blood Coagulation Factor;Blood Vessels;Bradykinin;Caring;Catheters;Cessation of life;Charge;Chemotaxis Induction;Clinical;clinical development;Clinical Trials;Coagulation Process;cytokine;Data;design;Development;Device or Instrument Development;Devices;druggable target;effective therapy;Enrollment;Enzyme Precursors;Epidemiology;Equipment Malfunction;Exposure to;Factor XI;Factor XII;Factor XII Deficiency;Generations;genetic risk factor;Healthcare;Hemorrhage;Hemostatic function;Human;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;intravenous administration;Laboratories;Maintenance;mechanical device;Mediating;Medical;Medical Device;Modeling;Modernization;Morbidity - disease rate;mortality;neutrophil;nonhuman primate;novel;Pathologic;Pathway interactions;Patients;Peptide Initiation Factors;Peripheral;Pharmaceutical Preparations;Phase I Clinical Trials;pre-clinical;Predictive Factor;prevent;prospective;Prospective cohort;randomized trial;Recombinants;Research Project Grants;response;Risk;risk/benefit ratio;Role;Safety;Sampling;screening;Serine Protease;Signal Pathway;Stream;Stroke;success;Surface;Symptoms;System;systemic inflammatory response;Testing;Thrombin;Thromboembolism;Thrombosis;Thrombus;ultrasound;Up-Regulation;Vascular Permeabilities;Whole Blood

PROJECT_TITLE: Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This study will provide clinical evidence about the chronic health issues that can appear and last for weeks or months in some patients after acute COVID-19 infection and impede their ability to work and function normally. The methods, tool, and findings of our project will enhance the healthcare system’s ability to identify early warning signs and factors that predispose patients for post-COVID health complications and will improve our capacity for more effective decision-making during pandemics.

PI_NAMEs: ESTIRI, HOSSEIN  (contact);MURPHY, SHAWN N

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Accounting;Acute;acute COVID-19;acute infection;Address;Affect;Anxiety;Appointment;Caring;Characteristics;Chest Pain;Chicago;Chronic;Clinical;Clinical Data;Code;cohort;Collection;Computational algorithm;Coronavirus;cost;Coughing;COVID-19;COVID-19 diagnostic;COVID-19 long hauler;COVID-19 pandemic;COVID-19 patient;Data;data modeling;Decision Making;Diagnosis;Diagnostic;Digital biomarker;Disease;Disparity;Dyspnea;Early identification;Electronic Health Record;epidemiologic data;Etiology;Fatigue;fighting;Future;Generations;Health;Healthcare Systems;Hospitals;Image;improved;Income;Infection;Informatics;informatics tool;insight;Institution;International Classification of Diseases;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Kentucky;Knowledge;Label;Laboratories;Learning;Long COVID;Medical;member;Memory impairment;Mental Depression;Methodology;Methods;Modeling;multidisciplinary;multimodal data;Mutation;Names;Neurocognitive;New England;novel;Organ;pandemic disease;patient population;Patients;Persons;Phase;Phenotype;Philadelphia;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Post-Traumatic Stress Disorders;Predisposing Factor;Preparation;Procedures;Prognosis;psychologic;Public Health;Pulmonary function tests;Pulmonology;Ramp;Recovery;repository;Research;Resolution;Risk;Risk Factors;SARS-CoV-2 infection;Sentinel;Severities;Side;Signs and Symptoms;Silver;Site;Strategic Planning;Structure;Symptoms;System;Testing;Therapeutic;Time;tool;Uncertainty;United States National Institutes of Health;Update;Vaccinated;Vaccination;Vaccines;Virus;Virus Diseases;Work

PROJECT_TITLE: Temporal Phenotypes and Risk Models for the Post-COVID Syndrome and its sub-types

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative We propose to develop a unique bioprinting strategy combining the digitally tunable microfluidic hollow fiber bioprinting method and the stretchable hydrogel-based bioink formulations, to generate structurally, mechanically, and functionally biomimetic blood vessels. This unique approach is anticipated to provide unprecedented future capacity for engineering non-branching macrovascular grafts of various sizes, shapes, and structures to significantly facilitate vascular transplantation.

PI_NAMEs: ZHAO, XUANHE  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Address;Anastomosis - action;Architecture;Arteries;Back;Biocompatible Materials;bioink;Biology;biomaterial compatibility;Biomimetics;bioprinting;Bioreactors;Blood;Blood capillaries;Blood flow;Blood Vessels;Cardiovascular system;cell type;Cells;Chemistry;Complex;Computer software;constriction;crosslink;Diameter;digital;Elastic Fiber;Elasticity;Endothelial Cells;Engineering;Ensure;Evaluation;experience;fabrication;Fiber;Fibroblasts;flexibility;Formulation;Future;Heart;hemodynamics;Hydrogels;In Vitro;in vivo;in vivo evaluation;Manuals;mechanical properties;Mechanical Stimulation;Mechanics;Medicine;Methods;Microfabrication;Microfluidics;Modeling;Mus;Nerve;Nutrient;Organ;Pattern;Physiological;Play;Polymers;Polysaccharides;Procedures;Property;Radial;Relaxation;repaired;Reporting;Reproducibility;Resolution;Rest;Rodent Model;Role;scaffold;Scheme;Series;Shapes;shear stress;Smooth Muscle Myocytes;Stretching;Structure;System;Technology;Tissue Engineering;Tissues;Transplantation;Transportation;Tunica Adventitia;Vascular Graft;Vascular Smooth Muscle;Veins

PROJECT_TITLE: Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood Vessels

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Stroke

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative:  Aneurysmal subarachnoid hemorrhage (aSAH) survivors have long term cognitive deficits and memory impairment in their productive years with major responsibilities with respect to work and family. Preliminary data suggests that Deferiprone could improve cognitive outcome in these subjects. Therefore, we propose a phase 1/2a single-center randomized double-blinded placebo vs. deferiprone trial to test these findings.

PI_NAMEs: HASAN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Address;Age;age group;Alzheimer's Disease;Alzheimer's disease risk;Amygdaloid structure;Aneurysmal Subarachnoid Hemorrhages;animal data;Animal Model;Animals;Apolipoprotein E;Atrophic;Attenuated;Behavioral;Blood;Blood - brain barrier anatomy;Brain;brain iron;Cells;Cerebral hemisphere hemorrhage;Chelating Agents;Clinical Research;Cognitive;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;cohort;Cohort Studies;Confidence Intervals;Control Groups;Cytolysis;Data;Databases;Death Rate;Dementia;Development;Diffuse;Disease Progression;Double-Blind Method;Drainage procedure;Enrollment;Erythrocytes;Exposure to;Family;Ferritin;General Population;genetic risk factor;Grant;hazard;high risk;Hippocampus;Hospitals;Human;human model;imaging study;Impaired cognition;improved;In Vitro;Intervention;Intraventricular;intraventricular hemorrhage;Iron;Iron Chelation;Ischemic Stroke;Lead;Lipids;Magnetic Resonance Imaging;Measures;Medical;Memory impairment;mild cognitive impairment;mouse model;neuroimaging;Neurologic Deficit;neuron loss;Neurons;Outcome;Pathway interactions;Phase;Placebos;population based;post stroke;preclinical study;Process;Productivity;Protocols documentation;Randomized;recruit;Reporter;Risk;risk variant;sex;standard of care;Standardization;Stroke;stroke survivor;Structure;Subarachnoid Hemorrhage;Subarachnoid Space;Survivors;Testing;Therapeutic Agents;Therapeutic Effect;Translating;Ventricular;Work;years of life lost

PROJECT_TITLE: The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The proposed research provides a set of comprehensive tools to perform integrative analysis of multimodal and multi-cohort data. The tools include generic estimation and inference methods that can address many practical problems raised in the integrative analysis, as well as a powerful computational tools to handle the block missing data. The proposed research can be directly applied to many biomedical research areas, such as Alzheimer's Disease studies, to improve the understanding of the disease mechanism and developing new treatments.

PI_NAMEs: LI, QUEFENG  (contact)

PROJECT_TERMS: Accounting;Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;American;Area;Bioconductor;Biomedical Research;cohort;Communities;Computer software;computer studies;computerized tools;Confidence Intervals;Data;Data Collection;data modalities;Dementia;Development;dimension reduction;Disease;Early Diagnosis;effective therapy;Elderly;Electronic Health Record;flexibility;Genetic;Grant;Heterogeneity;high dimensionality;imaging biomarker;imaging modality;improved;innovation;Literature;longitudinal analysis;Longitudinal cohort;Measurement;Measures;Methods;microbiome research;Modality;Modeling;Modernization;morphogens;multidimensional data;multimodal data;multimodal modeling;multimodal neuroimaging;multimodality;neuroimaging;Neurosciences;novel;Pattern;Performance;Population;Prevention;Progressive Disease;Property;Public Health;Research;resilience factor;Sampling;simulation;Statistical Methods;Statistical Models;Statistical Study;statistics;Testing;theories;tool;user friendly software

PROJECT_TITLE: Statistical Methods for Integrative Analysis of Large Scale Neuroimaging Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE When ovarian cancer is diagnosed at an early stage, combination surgery and chemotherapy can cure 90% of women with disease contained in the ovary (stage I) and 70% with disease limited to the pelvis (stage II), but when disease has spread further, cure slips to 20% or less. Our group has shown that annual measurement of CA125 followed by ultrasound, and surgery, if indicated, can detect early stage (I, II) disease in 71% of patients with no more than two-three operations for each case detected, but a multi-marker algorithm is likely to be required to impact mortality. Our Clinical Validation Center will continue to collaborate and to provide specimens to EDRN BCCs and test whether annual measurement of four blood tests detects early stage cases in >70% of cases with an acceptable number of benign ovarian lesions.

PI_NAMEs: BAST, ROBERT C (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: advanced disease;Algorithms;Antigens;Arizona;Autoantibodies;Benign;Biological Assay;Biological Markers;biomarker identification;Blood;Blood Tests;CA-125 Antigen;Cancer Center;Cancer Detection;cancer recurrence;chemotherapy;Clinical;Collaborations;collaborative trial;Combination Drug Therapy;Complement;Complex;Computer Models;CTAG1 gene;Diagnosis;Disease;disease heterogeneity;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Endometrial Carcinoma;Epithelial ovarian cancer;Evaluation;FOLR1 gene;General Hospitals;Goals;Grant;IL8 gene;Image;improved;Individual;Lead;Lesion;Link;Malignant neoplasm of ovary;Massachusetts;Measurement;Measures;mortality;novel marker;operation;Operative Surgical Procedures;osteopontin;Ovarian;Ovary;Patients;Peer Review;Pelvis;Plasma;Postmenopause;Predictive Value;preservation;Published Comment;Publishing;rapid test;Recurrence;Recurrent disease;Reporting;Research Personnel;Risk;routine screening;Sampling;screening;Screening for Ovarian Cancer;Second Look Surgery;Serum;Site;Specificity;Specimen;Technology;Testing;Time;Tissue Sample;Tissues;TP53 gene;Tumor Debulking;Ultrasonography;ultrasound;United Kingdom;United States;Universities;Vagina;Validation;WFDC2 gene;Woman

PROJECT_TITLE: MD Anderson Cancer Center EDRN- Clinical Validation Center for Early Detection of Ovarian Cancer with a multiple marker algorithm


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Lung;Organ Transplantation;Prevention;Transplantation

PHR: PROJECT NARRATIVE Current immunosuppressive regimens are unsuccessful in achieving acceptable long-term lung allograft and patient survival. By applying a novel agent with broad anti-inflammatory and immunosuppressive capabilities, we expect to not only improve patient survival but also reduce morbidity in the form of chronic rejection and thereby improve quality of life.

PI_NAMEs: HACHEM, RAMSEY ;KREISEL, DANIEL ;MADSEN, JOREN C (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Acute;adaptive immune response;Adrenal Cortex Hormones;Affect;Affinity;allograft rejection;Allografting;antagonist;Anti-Inflammatory Agents;Antibody Formation;antibody-dependent cell cytotoxicity;antibody-mediated rejection;Assessment tool;Autoantibodies;B cell differentiation;Binding;Biological Markers;biomarker selection;Bronchiolitis;Canada;Categories;Cell Count;cell free DNA;Cell Physiology;Cells;Cessation of life;Chronic;Chronic Childhood Arthritis;Clinical;Clinical Data;clinical practice;Clinical Trials;Clinical Trials Design;Complement-Dependent Cytotoxicity;cytokine;Data;design;Development;Diagnostic tests;Disease;donor-specific antibody;Dose;Double-Blind Method;Epitopes;Equilibrium;Experimental Models;Fibrosis;FOXP3 gene;Functional disorder;Future;Generations;Genetic Engineering;graft dysfunction;Hour;Human;humanized monoclonal antibodies;IgG1;IL-6 inhibitor;Immune;Immune response;Immune system;Immunity;immunoregulation;Immunosuppression;improved;improved outcome;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;Innate Immune Response;insight;Interleukin-6;Interleukins;Isoantibodies;isoimmunity;Kidney;kidney allograft;Lesion;Link;Lung;lung allograft;lung injury;Lung Transplantation;Lymphocyte;Maintenance;Mediating;Memory B-Lymphocyte;Morbidity - disease rate;mycophenolate mofetil;nano-string;Nature;novel;Outcome;Pathogenicity;Pathway interactions;Patients;Phase;Placebos;Plasmablast;post-transplant;predictive test;preservation;prevent;primary endpoint;Production;programs;prospective;Quality of life;Randomized;randomized placebo controlled trial;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;receptor;Refractory;Regimen;Regulatory T-Lymphocyte;Reperfusion Injury;response;retransplantation;Risk Assessment;Risk Factors;Saline;secondary endpoint;Signal Transduction;standard of care;Surface;Survival Rate;T cell response;T-Lymphocyte;Tacrolimus;Testing;Time;Tissues;transcriptomics;transplant centers;Transplant Recipients;Transplantation;Transplantation Immunology;Treatment Protocols

PROJECT_TITLE: Targeting Inflammation and Alloimmunity in Lung Transplant Recipients With Clazakizumab


ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: The Methods and Logic in Molecular Biology (MLMB) Training Program at Princeton University is a diverse and inclusive program that trains graduate students to become leaders in biomedical research, teaching, and related life science fields. We use a customized mentoring program that provides MLMB trainees with advanced skills in multi-disciplinary research, including critical thinking, generation of hypotheses, experimental design, data analysis and interpretation, and science communication, in conjunction with skills in leadership and mentoring. Research projects directed by MLMB program faculty train Ph.D. candidates in diverse areas related to human health, including reproduction and development, infectious disease, cancer, and aging.

PI_NAMEs: DEVENPORT, DANELLE N (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Methods and Logic in Molecular Biology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Parkinson's disease (PD) symptoms of postural instability and gait disorder (PIGD) cause profound disability and are inadequately treated by current therapies. This project uses new brain-imaging and computer-modeling techniques to comprehensively investigate how targeting deep brain stimulation (DBS) at specific path- ways on a patient-specific basis can effectively treat the disabling symptoms of PIGD.

PI_NAMEs: COOPER, SCOTT E (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Agreement;Anatomy;associated symptom;Basal Ganglia;Bradykinesia;Brain imaging;Bypass;Cell Nucleus;Clinical;Complex;Computer Models;Consumption;Coupled;Data;Data Set;Deep Brain Stimulation;deep field survey;design;Diffusion Magnetic Resonance Imaging;disability;Disabling;disabling symptom;Effectiveness;Efferent Pathways;Electric Stimulation;Electrodes;Environment;Equilibrium;Experimental Designs;Failure;Fiber;functional status;Gait;Gait abnormality;Globus Pallidus;Goals;High Resolution Computed Tomography;home test;Hour;Image;improved;individual patient;innovation;Institution;interest;Intervention Studies;Investigation;Laboratories;Lesion;Location;machine learning method;Magnetic Resonance Imaging;Measures;Modeling;Morphologic artifacts;Motor;motor impairment;motor symptom;MRI Scans;neural;Neural Pathways;Neurodegenerative Disorders;neuroimaging;non-motor symptom;novel;novel therapeutic intervention;Operative Surgical Procedures;Parkinson Disease;Pars Interna;particle;Pathway interactions;Patients;Pharmaceutical Preparations;phase I trial;Postoperative Period;posture instability;Process;programs;prospective;Quality of life;reduce symptoms;Research;response;Safety;Sample Size;STN stimulation;Structure;Structure of subthalamic nucleus;success;Symptoms;Techniques;Testing;Therapeutic;Time;tool;tractography;Work;X-Ray Computed Tomography

PROJECT_TITLE: Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDisease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Hematology

PHR: Duke’s training program in Hematology and Transfusion Medicine is dedicated to expanding the number and quality of research scientists pursuing research careers in blood disorders. We provide a comprehensive training program that allows trainees interested in blood research to become independent investigators and contribute to scientific advances to improve the health of millions of people with acquired blood disorders.

PI_NAMEs: AREPALLY, GOWTHAMI M (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Hematology;transfusion medicine

PROJECT_TITLE: Hematology & Transfusion Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Retinal pigment epithelium-choriocapillaris (RPE-CC) complex in the eye is compromised in age-related macular degeneration (AMD) and related maculopathies, like Sorsby’s fundus dystrophy (SFD). In this proposal, we will use induced pluripotent stem cell (iPSC)-derived RPE-CC model for studying the disease mechanism and testing potential drug therapies for AMD/SFD.

PI_NAMEs: SINGH, RUCHIRA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: activation product;Age related macular degeneration;Area;Atrophic;Biological Models;Bruch's basal membrane structure;causal variant;Cell Line;Choroidal Neovascularization;Complex;CRISPR/Cas technology;Data;Deposition;Development;Disease;disease mechanisms study;disease model;disorder of macula of retina;Drusen;Event;experimental study;extracellular;Extracellular Matrix;Eye;Eye diseases;Functional disorder;Funding;gene-editing approach;Goals;HMGB1 gene;Homeostasis;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;inhibitor;Intervention;knock-down;LDL-Receptor Related Protein 1;Link;lipid metabolism;Lipids;Lipoproteins;longitudinal analysis;Low Density Lipoprotein Receptor;Lysine;Macular degeneration;macular dystrophy;Matrix Metalloproteinases;Mediating;MMP2 gene;Modeling;Modification;Molecular;monolayer;Mutation;Outcome Measure;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Pattern;Peptides;pharmacologic;Pharmacotherapy;Phenotype;Phospholipase;rare variant;receptor for advanced glycation endproducts;Retinal Dystrophy;Role;Site;small hairpin RNA;small molecule;Sorsby's fundus dystrophy;stem cell model;Sterility;Structure of retinal pigment epithelium;Study models;Testing;Therapeutic;TIMP3 gene;Vision

PROJECT_TITLE: Delineating the role of TIMP3 in macular degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Glioma/glioblastoma is a family of malignant brain tumors that affects about 3 out of 100,000 people around the world every year and is barely treatable. The underlying cause of gliomas is still under investigation, but epigenetic changes are considered very important. This proposal will study how dysregulation of post- transcriptional modifications on small non-coding RNAs contributes to aberrant gene expression in gliomas.

PI_NAMEs: SU, ZHANGLI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Affect;Area;base;Base Pairing;Benchmarking;Biochemistry;Biogenesis;Bioinformatics;bioinformatics tool;Biological Process;Biology;Cancer Biology;cancer type;Cell Line;Cell Proliferation;Cells;Chemotherapy and/or radiation;Classification;common treatment;CRISPR screen;Data;Data Set;Development;Disease Management;effective therapy;Ensure;Environment;Epigenetic Process;experimental study;Family;Gene Expression;Gene Silencing;Genes;genomic tools;Genomics;Glioblastoma;Glioma;Goals;improved;in vivo;innovation;insight;Interruption;Investigation;Learning;Malignant neoplasm of brain;Malignant Neoplasms;Manuscripts;Mentors;MicroRNAs;Mining;Modification;Molecular Biology;mortality;Mus;new therapeutic target;novel;Operative Surgical Procedures;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Phenotype;Play;Positioning Attribute;posttranscriptional;Preparation;Primary Brain Neoplasms;Process;prognostic;Recurrence;Regulation;Regulator Genes;Research;RNA;Role;Sampling;Shapes;Site;skills;Small RNA;stem-like cell;Techniques;Testing;The Cancer Genome Atlas;therapeutic target;tool;Training;transcriptome;transcriptome sequencing;Transfer RNA;tumor;Universities;Untranslated RNA;Virginia;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The role of small RNA modifications in glioma

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation;Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE Human spinal cord injury (SCI) currently has no effective treatment, and thus any new treatments would have a significant impact on public health. In the United States, there are more than 12,000 new cases of SCI each year. While many groups have focused on therapies for subacute SCI, chronic SCI remains an unmet need, with an estimated 250,000 people currently living with chronic SCI in the US. Our long-term goal is to bring a successful cell transplantation therapy from bench to bedside for chronic SCI via a next-generation 3D printing approach.

PI_NAMEs: PARR, ANN M (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Acute;Address;Adult;Attention;Axon;axon guidance;behavioral study;bench to bedside;Biocompatible Materials;bioink;bioprinting;Cell Maturation;Cell Survival;Cell Transplantation;cell type;Cells;Chronic;Cicatrix;clinically relevant;combinatorial;Complex;Contusions;Custom;design;Dimensions;Dorsal;effective therapy;Electrophysiology (science);Future;Goals;Histologic;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;induced pluripotent stem cell;injured;Injury;Knowledge;Lesion;Location;Methods;Modeling;Natural regeneration;nerve stem cell;neural circuit;neural network;neuron development;Neurons;neuroprotection;neurotransmission;next generation;novel;Nuclear Pore Complex;Organoids;Patients;Persons;Population;Process;Public Health;Publishing;Rattus;Recovery of Function;regenerative approach;Reporting;Research;Rodent;Rodent Model;scaffold;self assembly;Site;Specificity;Spinal;Spinal Cord;Spinal cord injury;stem cell population;Synapses;System;Testing;Translating;Translations;Transplantation;transplantation therapy;United States;Work

PROJECT_TITLE: 3D Bioprinted Spinal Cord Organoids as a Relay System for Spinal Cord Injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative: Preeclampsia is a major medical disorder occurring during pregnancy and brings about more than 50,000 maternal deaths worldwide, with an estimated 45,000 death is in US alone, however, biological mechanisms underlying preeclampsia pathology are unknown. Our investigations will utilize a novel complement activation- based mouse model to investigate molecular mechanisms of complement induced signaling in preeclampsia pathology. These studies will provide an insight into fundamental processes involved in preeclampsia pathology and is crucial in the future exploration of new therapeutic targets and thus reduce morbidity and mortality in women.

PI_NAMEs: BANADAKOPPA, MANU ;YALLAMPALLI, CHANDRASEKHAR  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Ablation;activation product;ADAMTS;Allogenic;Amniotic Fluid;Angiogenesis Inhibitors;Arteries;Biological;C3AR1 gene;CD46 Antigen;Cell membrane;Cessation of life;Circulation;Coagulation Process;Complement;Complement 3a;Complement 3d Receptors;Complement 5a;Complement Activation;Complement Factor H;Complement Membrane Attack Complex;Complement Receptor;cytokine;Cytoprotection;Data;Deposition;Disease;Embryo;Endothelial Cells;Epidemiology;fetal;Fetal Growth Retardation;Fetal Reduction;Fetus;Fibrin;Fibrinogen;Functional disorder;Future;Genes;Genetic Polymorphism;Genetic Predisposition to Disease;High Prevalence;Homeostasis;Human;Hypertension;IL6 gene;IL8 gene;Inflammatory;inflammatory milieu;inhibitor;Injury;insight;Interleukin-6;Investigation;Kidney;Link;Liquid substance;Liver;Mannose Binding Lectin;Maternal Mortality;Maternal-Fetal Exchange;Mediating;Medical;Methodology;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Nature;new therapeutic target;normotensive;novel;Pathogenesis;Pathologic;Pathology;pathophysiology of preeclampsia;Pathway interactions;Peripheral;Phase;Placenta;Plasminogen Activator Inhibitor 1;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Process;Proteins;Regulation;Relaxation;Reporting;response;Rodent;Role;Signal Induction;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Spiral Artery of the Endometrium;Spontaneous abortion;STAT3 gene;Syndrome;System;Testing;Therapeutic;Thromboplastin;TNF gene;Transgenic Mice;Up-Regulation;Uterus;Vascular blood supply;Vascular Diseases;Villous;von Willebrand Factor;Woman;Women's mortality;Y protein

PROJECT_TITLE: Evaluating role of complement activation induced signaling pathways in preeclampsia pathology using a novel complement activation-based mouse model

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: NARRATIVE The overall goal of this proposal is to evaluate the feasibility of a social marketing public health strategy for reducing HIV-related stigma, and associated intersectional stigma, among young people (18-29 years) living with HIV, or at high-risk of HIV acquisition, in an urban Latin American setting. Using theory-based approaches for stigma reduction and health communications, and input from key stakeholders, we will create a series of multimedia content (short videos, music videos, comics, memes) and study whether influencers are willing to share the content via their social media platforms. We will generate evidence of potential efficacy of the content and the intervention as a whole.

PI_NAMEs: FRANKE, MOLLY FORREST (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adolescent;AIDS prevention;antiretroviral therapy;Attitude;Behavior;behavior change;Belief;Cartoons;Collaborations;Communities;design;Development;Effectiveness;Epidemiology;Evaluation;evidence base;experience;Exposure to;Focus Groups;Friends;Future;Goals;Health;health communication;high risk;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;Individual;Information Dissemination;Intervention;intervention delivery;intervention effect;Joints;Knowledge;Language;Latin America;Latin American;Learning;marginalization;Measures;meetings;Methods;Motivation;Multimedia;Music;Nature;online community;Outcome;Participant;Pathway interactions;Patients;peer;Persons;Peru;Population;programs;Public Health;Randomized;recruit;Research;Series;service delivery;Services;social engagement;Social Marketing;social media;Social Network;social stigma;Spanish;Stigmatization;tailored messaging;Testing;theories;tool;transgender women;transmission process;Treatment Efficacy;United Nations;Update;uptake;Viral;willingness;young men who have sex with men;Youth

PROJECT_TITLE: Feasibility of a community-engaged social marketing strategy to reduce HIV-related stigma and improve health among young people

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE This training grant will support pre-doctoral students engaged in research in Cell Biology, Molecular Biology, and Genetics. The program will train a diverse group of outstanding students and prepare them to enter the biomedical research workforce as scientists who will perform basic research. This basic research has important applications to human health issues including cancer, developmental problems, diabetes, and infectious disease.

PI_NAMEs: QUERY, CHARLES C (contact)

PROJECT_TERMS: Cellular biology;Genetic;Molecular Biology;Training Programs

PROJECT_TITLE: Training Program in Cellular and Molecular Biology and Genetics


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE The objectives of the proposed research are to build a causal pathway framework that helps us understand how multi-level social determinants and intermediary factors related to health and quality of health care together lead to severe maternal morbidity and its disparities. We will use this framework to analyze population-level data from multiple states. Our findings will enable us to identify actionable strategies to prevent this life-threatening outcome and promote equity in maternal health.

PI_NAMEs: CARMICHAEL, SUZAN L (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Affect;American Indian Women;Anemia;Attention;Birth;Black American;Caring;Censuses;Cesarean section;Clinical;Communities;comorbidity;Complex;Country;County;Data;Data Set;design;Discipline of obstetrics;disparities in morbidity;Disparity;disparity reduction;Equity;ethnic disparity;evidence base;Health;health care availability;health care quality;health disparity;health inequalities;Health Services;Health Services Accessibility;Hospitals;Hypertension;implicit bias;Improve Access;improved;Income;Individual;Inequality;Inequity;Institutionalization;Intervention;Joints;Knowledge;large scale data;Lead;Life;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Methods;multidisciplinary;Neighborhoods;Outcome;Pathway Analysis;Pathway interactions;Perinatal;Physiological;Population;Predisposition;Pregnant Women;prevent;Prevention strategy;Quality of Care;racial disparity;racism;Research;Resources;Risk;Sentinel;severe maternal morbidity;social determinants;Social Environment;social epidemiology;social factors;sociodemographics;socioeconomic disadvantage;Solid;trend;Woman;women of color

PROJECT_TITLE: Building a causal pathway framework to identify interventions to eliminate racial/ethnic disparities in severe maternal morbidity

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Principal Investigator/Program Director (Last, first, middle): Wu, Jianqiang Public Health Relevance Statement (Narrative attachment) Neurofibromatosis type 1 (NF1) is an inherited disease predisposing affected individuals to plexiform neurofibromas (PNFs) on which no effective therapy available. This proposal will study the mechanism(s) of Runx and VCP regulated proteostasis and adaptive endoplasmic reticulum (ER) stress in neurofibromagenesis and test if overwhelming of irresolvable ER stress signaling by targeting VCP will provide novel therapy for PNFs. This will provide proof-of-concept for testing MEK-independent cytotoxic and/or durable therapy for PNFs.

PI_NAMEs: WU, JIANQIANG  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Affect;Apoptosis;ATF6 gene;ATP phosphohydrolase;Automobile Driving;Benign;Biochemical;biological adaptation to stress;Cell Proliferation;Cell Survival;Cell Transplantation;Cells;Cellular Assay;Clinical Trials;Code;Coenzymes;comparison control;Cytostatics;cytotoxic;Cytotoxic Chemotherapy;cytotoxicity;Data;effective therapy;efficacy testing;Endoplasmic Reticulum;endoplasmic reticulum stress;enzyme activity;FDA approved;Genes;Genetic;Goals;Growth;GTPase-Activating Proteins;Hereditary Disease;Human;Image;imaging modality;in vivo;Individual;Induction of Apoptosis;inhibitor;knock-down;Language;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Measures;Mediating;MEK inhibition;MEKs;Methods;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;Nature;neoplastic cell;neurofibroma;Neurofibromatosis 1;NF1 gene;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Oncogenes;Operative Surgical Procedures;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;phase 1 testing;Phosphotransferases;Play;Plexiform Neurofibroma;pre-clinical;Prevention;preventive intervention;Principal Investigator;programs;Proliferating;Protein Biosynthesis;protein degradation;Protein Kinase;protein protein interaction;Proteins;proteostasis;public health relevance;RAS inhibition;Research Design;response;ribosome profiling;RNA;Role;Schwann Cells;Signal Pathway;Signal Transduction;small hairpin RNA;Structure;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissues;Translating;transplant model;tumor;tumor growth;tumor initiation;Tumor Promotion;tumorigenesis;Ubiquitination;valosin-containing protein

PROJECT_TITLE: MiR-155 and RUNX function in neurofibroma tumorigenesis and therapy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Inherited retinal degeneration diseases like retinitis pigmentosa (RP) are caused by genetic defects leading to photoreceptor cell loss, irreversible loss of vision and eventual blindness. However, it is unclear how photoreceptors die or how to slow/stop/reverse this process. To better understand the disease mechanism and develop new therapies, we propose to: investigate whether the PARP dependent cell death pathway acts as a common RP mechanism; identify compounds which promote photoreceptor survival in new RP zebrafish model via perform in vivo phenotypic drug screening; and validate identified compounds in established mouse RP models.

PI_NAMEs: ZHANG, LIYUN  (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Acceleration;Affect;anti-epileptic agents;Behavior;Biological Assay;Biological Models;Blindness;Categories;Cell Death;Cell Death Process;Cell Survival;Cells;Cessation of life;Clinical Trials;CRISPR/Cas technology;Data;Degenerative Disorder;Disease;disease model;Disease Pathway;DNA Sequence Alteration;Dose;drug candidate;Drug Delivery Systems;drug discovery;Drug Modelings;drug repurposing;Drug Screening;Drug Targeting;Etiology;Exhibits;Fishes;Fluorescence;Gene Targeting;Genes;Genetic;Genetic Models;Goals;High Pressure Liquid Chromatography;Homologous Gene;Human;human disease;improved;in vivo;Inherited;inherited retinal degeneration;insight;Intervention;Investigation;Kinetics;Knock-out;Label;Larva;Lead;Link;Measures;Mediating;Methods;Microscopy;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;neuroprotection;Neuroprotective Agents;novel;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;photoreceptor degeneration;Photoreceptors;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;preservation;Process;Proteins;Publishing;Reader;Research;Resources;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;rho;Rod;Role;Route;screening;Series;Severities;Signal Transduction;small molecule;Structure of beta Cell of islet;System;Testing;Therapeutic;therapeutic evaluation;Therapeutic Index;Therapeutic Intervention;Time;Transgenic Organisms;Translations;Vision;Visual;Whole Organism;Work;Zebrafish

PROJECT_TITLE: Drug Screening for Neuroprotectants in Novel Zebrafish Models of Retinitis Pigmentosa

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Neurosciences;Rehabilitation;Schizophrenia

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Relevance: The brain possesses the remarkable plastic ability to change its connectivity, which is often disrupted following injury or neurological disorder, making these plastic mechanisms a target of brain stimulation-based therapies. The goal of this study is to integrate principles from multiple plasticity mechanisms to enhance our ability to induce functional connectivity changes through neural stimulation and promote functional recovery following injury. The results of this study will then be used to inform the development of stimulation-based therapies for neurological disorders, for example to restore lost functions or behaviors following injury.

PI_NAMEs: KHATEEB, KARAM  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affect;Anatomy;Animal Model;Behavior;behavior measurement;Brain;career;Categories;Cognition;Complex;design;Development;Disease;Educational process of instructing;Electric Stimulation;Engineering;Epilepsy;excitatory neuron;Exhibits;experience;experimental study;Feedback;functional restoration;Future;Genetic;Goals;Growth;Human;improved outcome;in vivo;Injury;injury recovery;insight;Lesion;Long-Term Potentiation;Macaca mulatta;Measures;Memory;Mentors;Methods;Nature;neglect;Nervous System Disorder;neural;neural circuit;neural stimulation;Neurologic Deficit;Neurons;nonhuman primate;optogenetics;Outcome;Phase;Physiological;Physiology;Play;Positioning Attribute;Postdoctoral Fellow;postsynaptic;postsynaptic neurons;presynaptic neurons;Protocols documentation;Publishing;receptive field;Recovery of Function;Research;Research Personnel;Research Project Grants;Rodent;Role;Schizophrenia;Sensory Deprivation;Site;skills;Stroke;Synapses;Synaptic plasticity;Technical Expertise;Techniques;Technology;Testing;tool;Viral

PROJECT_TITLE: Co-engineering Hebbian and Homeostatic Plasticity Mechanisms to Induce Targeted Functional Neural Connectivity Changes


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Services;Patient Safety;Pediatric;Precision Medicine

ORG_CITY: PHOENIX

ORG_NAME: PHOENIX CHILDREN'S HOSPITAL

ORG_STATE: AZ

PHR: Cleft palate is the most common pediatric craniofacial anomaly, and up to 40% of children with cleft palate will develop severe limitations in speech intelligibility and acceptability due to velopharyngeal insufficiency (VPI). This research will compare the effectiveness of existing surgical procedures for VPI, establishing which procedures are most effective at improving speech and determining the risks of each procedure. The results will directly contribute to NIDCR’s mission to improve the health of children with craniofacial anomalies by enabling surgeons to select the most effective, least harmful surgical procedure for each child with VPI.

PI_NAMEs: SITZMAN, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Affect;Air;Anatomy;Behavior;Child;Child Health;Childhood;Cleft Palate;Communication;comparative effectiveness study;compare effectiveness;cost;cost effective;Craniofacial Abnormalities;Deformity;early experience;Effectiveness;effectiveness evaluation;Enrollment;Evaluation;Exhibits;experience;Goals;Growth;imaging modality;implementation science;improved;Interview;Knowledge;Language;Length;Literature;Magnetic Resonance Imaging;Methods;Mission;morphological criteria;Morphology;Muscle;National Institute of Dental and Craniofacial Research;Nose;Obstruction;Obstructive Sleep Apnea;operation;Operative Surgical Procedures;Outcome;Palate;palate repair;Participant;Pathologist;Patient Outcomes Assessments;Patient Selection;Patients;peer;Performance;personalized approach;personalized medicine;Procedures;Process;Provider;Quality of life;recruit;repaired;Research;Resolution;Risk;Risk Reduction;Selection Criteria;Self Perception;soft tissue;Speech;Speech Intelligibility;Subgroup;Surgeon;Symptoms;Testing;Velopharyngeal Insufficiency;Visualization

PROJECT_TITLE: Velopharyngeal insufficiency following cleft palate repair: a comparative effectiveness study of existing surgical procedures and identification of criteria to guide a personalized treatment approach


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Immunotherapy;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Chronic obstructive pulmonary disease (COPD) is a highly prevalent and progressive lung disease that leads to significant morbidity and mortality, yet there are no current therapies to stop lung function decline. A better understanding of the mechanisms underlying COPD pathogenesis, particularly related to the role of the immune cells which infiltrate the lungs in COPD, are necessary to develop therapies. This study will test the hypothesis that dendritic cells and regulatory T cells are dysregulated in COPD and that restoring appropriate regulatory T cell functions could be a potential immunotherapy to treat patients with COPD.

PI_NAMEs: MENGISTU, DAWIT  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acceleration;Adoptive Transfer;Air;airway obstruction;Automobile Driving;Blocking Antibodies;Breathing;Cause of Death;cell killing;Cell Physiology;Cell Separation;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced COPD;Clinical;Clinical Trials;Coculture Techniques;Complement;Consent;Coughing;cytokine;Cytokine Signaling;cytotoxicity;Data;Dendritic Cells;Development;Disease;disease model;Disease Progression;effector T cell;Environment;Epithelial Cells;Equipment;Excision;exposure to cigarette smoke;Feedback;Flow Cytometry;Genes;Goals;Healthcare Systems;Homeostasis;Host Defense;Human;human data;Immune;Immune system;Immunology;Immunosuppression;Immunotherapy;Individual;Infiltration;Inflammatory;inflammatory milieu;Inhalation;Knowledge;Laboratories;Leukocytes;Location;Lung;Lung Diseases;Measures;member;Michigan;microscopic imaging;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mus;Natural Killer Cells;novel therapeutic intervention;Operative Surgical Procedures;Oxidants;Pathogenesis;Patients;Phenotype;polarized cell;Population;pre-clinical;prevent;Production;programs;Progressive Disease;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Regulation;Regulatory T-Lymphocyte;Research;response;Role;Sampling;Smoke;Smoker;Structure of parenchyma of lung;T cell differentiation;T cell therapy;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapy development;time use;Training;Translational Research;United States;University resources

PROJECT_TITLE: Understanding Dysregulated Crosstalk Between Regulatory T Cells and Lung Dendritic Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Early-life adversity (ELA), including interpersonal trauma and/or loss, family dysfunction and poverty, is highly prevalent and has profound psychological, biological and social impacts, as well as lasting negative effects on health and well-being. Persons with ELA misuse alcohol, nicotine and illicit drugs at an earlier age, have a quicker transition to substance use disorders (SUD), and a more pernicious clinical course compared with those who did not experience ELA. Using a longitudinal design, this project aims to examine the development of SUD during adolescence, a period of high risk for SUD, among youth with none, low and high levels of ELA and identify the clinical, biobehavioral and family-environmental factors that influence the association between ELA and SUD.

PI_NAMEs: RAO, UMA  (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Accidents;Address;Adolescence;Adolescent;Adult;adverse childhood events;Adverse event;Age;Age of Onset;alcohol and other drug;Alcohol dependence;alcohol exposure;alcohol misuse;Behavior;Behavioral;behavioral response;Behavioral Symptoms;Binding;biobehavior;Biological;Blood;Brain;C-reactive protein;Cells;Cessation of life;Childhood;Clinical;Clinical Trials;Communities;comorbidity;contextual factors;Coping Skills;critical developmental period;critical period;cytokine;Development;Disease;disorder risk;Dose;Drug Addiction;Drug usage;Dryness;Early Diagnosis;early life adversity;early onset substance use;Economic Burden;economic cost;emotion dysregulation;Emotions;Environmental Risk Factor;executive function;Exhibits;experience;Exposure to;Family;Feedback;Female;follow-up;foster care;Functional disorder;Gene Expression;Genes;Genetic Transcription;genomic profiles;Glucocorticoid Receptor;Hair;Health;Health Care Costs;health disparity;high risk;high risk population;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Illicit Drugs;Immune;Immunologic Markers;Immunology procedure;Incidence;indexing;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interferons;interpersonal trauma;intervention program;Investigation;Knowledge;Link;longitudinal design;Measures;Mediating;Mental disorders;Methodology;Methods;mortality;neural circuit;Neuroimmune;Neuronal Plasticity;neurotoxic;Nicotine;novel;Nuclear;Onset of illness;Overdose;Parent-Child Relations;Participant;Pathogenesis;Pathology;Pathway interactions;Performance;Personal Satisfaction;personalized care;Persons;Pharmaceutical Preparations;Poverty;Prevention;Prevention program;Probability;Process;prospective;protective factors;psychiatric symptom;psychobiologic;psychologic;Receptor Signaling;Recording of previous events;recruit;relapse risk;Reporting;Research;resilience;response;reward processing;Rewards;Risk;Risk Factors;risk mitigation;Role;Sampling;Severities;Smoking;Social Impacts;Social support;socioeconomics;Specificity;Spottings;Stimulus;substance misuse;substance use;Substance Use Disorder;Sympathetic Nervous System;Symptoms;System;Testing;theories;transcription factor;treatment response;Viral;Whole Blood;Youth

PROJECT_TITLE: Effects of Early Life Adversity on Substance Use Problems in Adolescents: Biobehavioral Risk Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: DEMAURO, SARA BONAMO;HUANG, HAO  (contact)

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 3/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PI_NAMEs: GARAVAN, HUGH P.;POTTER, ALEXANDRA S (contact)

PROJECT_TITLE: 20/24 The Healthy Brain and Child Development National Consortium


ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project narrative The division of our genome into 22 autosomes and an X and Y chromosome with only a small region of homology is one of the most fundamental descriptions of our genome. However, we lack a clear understanding of the forces that have led to genome organization on this scale. This application will identify the forces that lead to changes in chromosome number, sex chromosome systems, and sex chromosome morphology across the tree of life and identify those forces likely to be acting on the human genome today and in the past.

PI_NAMEs: BLACKMON, HEATH  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: antagonist;autosome;Characteristics;Chromosomes;comparative;Congenital chromosomal disease;Evolution;Experimental Designs;Genetic;Genetic Epistasis;Genetic Recombination;Genetic Variation;Genome;genomic data;Genomics;Goals;Human Genome;insight;Klinefelter's Syndrome;Life;life history;Link;Meiosis;Methods;Modeling;Morphology;Nature;phenotypic data;Phylogenetic Analysis;programs;Research;segregation;Sex Chromosomes;Shapes;Structure;System;Testing;theories;Time;trait;Trees;Turner's Syndrome;Variant;Work;Y Chromosome

PROJECT_TITLE: Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Tobacco

ORG_CITY: HONOLULU

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE  In recent years, there has been an exponential growth of youths’ e-cigarette use nationally and in the State of Hawai‘i [1, 2], which has been associated with adverse health consequences, such as e- cigarette/vaping-associated lung injury (EVALI), susceptibility to COVID-19 [2, 7], and asthma [8]. In Hawai‘i, 30% of current e-cigarette users in middle/intermediate school are of Native Hawaiian or Pacific Islander ancestry, representing the highest percentage of users in this age group among the major ethnic groups in Hawai‘i [1]. This study actively engages rural communities in the development and evaluation of a culturally grounded e-cigarette/vaping prevention intervention for Hawaiian youth, complementing existing population- based efforts to address the e-cigarette epidemic affecting the State of Hawai‘i and Continental U.S.

PI_NAMEs: OKAMOTO, SCOTT KIYOSHI (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Affect;Age;age group;alcohol tobacco and other drug use;American Indians;Area;Asthma;Behavior;Clip;combustible cigarette;Communities;Control Groups;Coupled;COVID-19 susceptibility;Data;design;Development;Disparity;Drug usage;Education;Educational Curriculum;efficacy evaluation;Electronic cigarette;electronic cigarette use;electronic cigarette user;Electronic Nicotine Delivery Systems;Electronics;Environment;Epidemic;epidemiology study;Ethnic Population;Evaluation;evidence base;experience;Film;Focus Groups;follow-up;Foundations;Funding;Ground Substance;Growth;Guam;Hawaii;Hawaiian;Health;high risk;High School Student;Immersion;Indigenous;Intervention;Interview;Island;junior high school;Light;Link;Location;Marshall Islands;Media Campaign;Middle School Student;National Institute of Drug Abuse;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Pacific Islands;Parents;peer influence;Pharmaceutical Preparations;Photography;Policies;Population;population based;Prevalence;prevent;prevent ATOD use;Prevention;Prevention program;Prevention Research;Prevention strategy;preventive intervention;Printed Media;Production;racial population;Randomized, Controlled Trials;Reporting;Research Personnel;Research Proposals;Risk;Rural;Rural Community;school environment;Schools;social;Social Environment;social media;statistics;Students;substance abuse prevention;surveillance data;Survey Methodology;Surveys;teacher;therapy development;Treatment Efficacy;trend;United States;United States National Institutes of Health;vape pens;vaping;vaping associated lung injury;vapor;Waiting Lists;Youth

PROJECT_TITLE: The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Overall Project Narrative Alcohol misuse has broad effects on the HIV epidemic, both domestically and globally, contributing to HIV transmission and poor outcomes for those in HIV care. The proposed renewal of the Brown University Alcohol Research Center on HIV (ARCH) will support collaborative research to evaluate the most effective ways to address alcohol misuse in HIV prevention and care through the use of novel HIV staff training models and technology-assisted interventions. Results of ARCH research will directly inform approaches to reduce the substantial social and health costs associated with the co-occurrence of alcohol misuse and HIV.

PI_NAMEs: KAHLER, CHRISTOPHER W. (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;Advisory Committees;AIDS prevention;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol research;alcohol screening and brief intervention;Alcohols;antiretroviral therapy;Behavior Therapy;Behavioral;Caring;Clinical;Clinical effectiveness;co-infection;Collaborations;comorbidity;Continuity of Patient Care;Country;Data;Data Analyses;data management;Decision Making;Diagnosis;Effectiveness;Effectiveness of Interventions;effectiveness research;effectiveness testing;effectiveness/implementation trial;Epidemic;extend lifespan;Federally Qualified Health Center;Fostering;Funding;Funding Opportunities;Future;Grant;Health Care Costs;Heavy Drinking;Hepatitis;high risk sexual behavior;HIV;home test;Human immunodeficiency virus test;Human Resources;Hybrids;implementation framework;implementation research;implementation science;implementation trial;Incidence;Individual;Infection;infection risk;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;International;Intervention;Intervention Studies;Investigation;Knowledge;Laboratories;Liver diseases;Measures;men who have sex with men;Methods;Modeling;Morbidity - disease rate;mortality;motivational intervention;National Institute on Alcohol Abuse and Alcoholism;Neurocognitive Deficit;neuroinflammation;novel;Outcome;Pathway interactions;Patients;Persons;Phase;Pilot Projects;Population;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;Prevention;Prevention approach;Probiotics;programs;Public Health;Recording of previous events;Research;Research Activity;Research Methodology;Research Personnel;Research Priority;Resources;Risk;Role;Sampling;self testing;sex risk;sexual risk behavior;social;South Africa;Structure;Technology;technology intervention;telehealth;Testing;text messaging intervention;therapy adherence;Training;Training Programs;Translating;transmission process;trial design;Universities;video coaching;Viral;viral transmission;web-based intervention;web-enabled;Work

PROJECT_TITLE: Addressing alcohol misuse in HIV prevention and care: The Brown University Alcohol Research Center on HIV (ARCH)