NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Well-characterized longitudinal epidemiological cohorts are crucial resources for identifying novel risk factors, examining exposure-outcome associations, and determining the role of biomarkers in disease development and progression. The Survey of the Health of Wisconsin (SHOW) – a cohort representative of the state of Wisconsin has baseline and longitudinal follow-up data and environmentally annotated biological specimens on participants who consented for use of their data and specimens in future unspecified research, which makes SHOW an invaluable resource for environmental epidemiology research. We propose SHOW-Forward to further expand and diversify the SHOW cohort and establish the SHOW Real World Data Collaborative infrastructure to ensure enduring access for the scientific community to well-characterized and rich cohort data, including social determinants of health, multiple exposures, health outcomes, and biological specimens.

PI_NAMEs: MATHEW, JOMOL P (contact)

PROJECT_TERMS: African American;Age;Area;Biological;Biological Assay;Biological Markers;Biomedical Research;Black Populations;Black race;Chemical Exposure;Child;cloud based;cohort;Collection;Communities;Community Relations;Consent;Country;Data;data access;data ecosystem;data infrastructure;data integration;Data Reporting;Death Rate;deprivation;Development;Disease;DNA;Early Diagnosis;Early treatment;Education;Enrollment;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidemiology;epidemiology study;Ethics;ethnic health disparity;evidence base;experience;follow-up;Foundations;Funding;Future;Genetic;Goals;Grant;Health;health care availability;health determinants;Health Surveys;high risk;Human;Improve Access;improved;indexing;Industry;Infant Mortality;Infrastructure;innovation;Interdisciplinary Study;Investments;Latinx;lifestyle factors;Measurement;Measures;Methylation;microbiome;Mission;Modality;Modeling;multidimensional data;National Institute of Environmental Health Sciences;Neighborhoods;novel;novel strategies;operation;Outcome;outreach;Participant;Pathway interactions;Patient Recruitments;Population;Prevention;Privacy;privacy protection;Procedures;Process;programs;Proteins;Publications;Quality Control;Questionnaires;racial health disparity;recruit;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;Role;rural area;rural disparities;Rural Population;Sampling;Secure;social;social health determinants;Source;Specimen;Standardization;Structure;Survey Methodology;tool;Translational Research;Translations;Underrepresented Populations;Underserved Population;United States;United States National Institutes of Health;urban area;Urban Population;Wisconsin;Work

PROJECT_TITLE: SHOW-Forward: A pathway for enhancing participant diversity, enriching data, and improving access to a unique environmental epidemiology cohort


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The Mount Sinai StARR program - NIAID provides access to formative research experiences during residency providing a novel onramp to physician scientist careers in infectious diseases, allergy and immunology to enhance and diversify the pipeline of clinician investigators.

PI_NAMEs: CHEN, BENJAMIN K (contact);CHU, JAIME C;GALLAGHER, EMILY JANE

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Address;Aptitude;Award;Basic Science;Biomedical Research;career;career development;Child Health;Childhood;Clinical;clinical care;Clinical Immunology;Clinical Research;Communicable Diseases;Competence;Country;Data;design;Development Plans;Doctor of Philosophy;Educational Curriculum;Educational workshop;Ensure;Environment;equity, diversity, and inclusion;experience;Extramural Activities;Fellowship;Fellowship Program;Fostering;Funding;Future;Goals;graduate medical education;Grant;Health system;Hypersensitivity;Immune System Diseases;Immunology;Individual;Infectious Diseases Research;Infrastructure;interest;Internal Medicine;International;journal article;K-Series Research Career Programs;Literature;Medical Research;medical schools;Medicine;meetings;Mentors;Mentorship;Methodology;Mission;National Institute of Allergy and Infectious Disease;National Research Service Awards;novel;Pathway interactions;Pediatrics;Peer Review;Physicians;Postdoctoral Fellow;Program Evaluation;programs;Publications;Ramp;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Residencies;Rheumatology;Rotation;Scientist;success;Teacher Professional Development;theories;tool;Training;training opportunity;translational pipeline;Translational Research;translational research program;United States;United States National Institutes of Health

PROJECT_TITLE: Mount Sinai StARR Program - NIAID

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-Z (S1)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Research supported by NIAID has allowed scientists to use recent advances in DNA analysis to provide the research community with millions of antibody sequences from healthy individuals and from patients with autoimmune disorders. This proposal is designed to develop a strategy that uses this information to improve and lower the cost of therapeutic antibodies which today are one of the most effective strategies for treating a variety of illnesses including cancer, allergies, infections, and cardiovascular diseases. The results of this work may also be used in future studies to develop new and more effective therapies for the treatment of autoimmune illnesses such as multiple sclerosis and lupus.

PI_NAMEs: SCHROEDER, HARRY WILLIAM (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Algorithms;Amino Acids;Animal Model;Animals;Anti-DNA Antibodies;Anti-Idiotypic Antibodies;Antibodies;Antibody Binding Sites;Antibody Repertoire;antigen binding;Autoantibodies;Autoimmune;Autoimmune Diseases;Binding;Binding Sites;Bioinformatics;Cardiovascular Diseases;Charge;Clinical;Clinical Trials;clinically significant;Code;Communities;Complementarity Determining Regions;cost;Data;Databases;design;Development;Disease;Disease remission;DNA analysis;Doctor of Medicine;Doctor of Philosophy;effective therapy;Epitopes;Financial Support;Frequencies;Funding;Funding Mechanisms;Future;Gene Rearrangement;Genome;Goals;Human;Hydrophobicity;Hypersensitivity;Immune;Immune response;immunogenic;immunogenicity;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunology;improved;in silico;In Vitro;in vivo;Individual;Infection;infliximab;Inherited;Insulin-Dependent Diabetes Mellitus;Literature;Lupus;Machine Learning;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medical;medical schools;member;Monoclonal Antibodies;Multiple Sclerosis;Mus;National Institute of Allergy and Infectious Disease;novel therapeutics;Nucleotides;Operative Surgical Procedures;Outcome;pathogenic autoantibodies;Pathogenicity;Pathologic;Patients;Pentas;Pharmaceutical Preparations;physical property;Play;Population;prediction algorithm;protein aminoacid sequence;Proteins;Proteome;public database;Reaction;Reporting;Research;Research Personnel;Research Project Grants;Research Support;restraint;Rheumatoid Arthritis;Role;Scientist;secondary analysis;Structure;success;System;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic antibodies;tool;Vaccines;Work

PROJECT_TITLE: Divergence of V-region sequences from the human proteome as a factor in autoimmune diseases and the immunogenicity of therapeutic antibodies.

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Substance use and co-occurring mental health concerns continue to be a major public health concern among youth in the foster care system making access to substance use prevention services a key priority. Digital behavioral health technologies have the potential to rapidly and efficiently increase access to prevention resources and interventions, but linkage to such available technologies requires facilitation by systems already serving these youth. The proposed Hybrid II mixed methods study will evaluate implementation effectiveness of a telementoring program with Court Appointed Special Advocates (CASA) to increase foster youth referrals to a digital behavioral health app (FostrSpace) and determine FostrSpace's effectiveness in preventing youth substance use.

PI_NAMEs: TOLOU-SHAMS, MARINA  (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Address;adolescent substance use;Adoption;Adult;Advocate;Age;Attitude;Automobile Driving;behavior change;Behavior Therapy;behavioral health;behavioral health intervention;California;care systems;Characteristics;Child Abuse and Neglect;child neglect;Child Welfare;Client;Clinical Trials Design;Cognition;Communities;Community Health;community violence;Computer software;contextual factors;cost;cost effective;County;court;Data;design;digital;digital delivery;Dimensions;Economics;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation hybrid;Emotional;Environment;evidence base;experience;feasibility testing;Feedback;foster care;Fostering;Gatekeeping;Health;health care availability;health practice;Health Services Accessibility;Health Technology;housing instability;Hybrids;implementation evaluation;implementation intervention;implementation strategy;implementation/effectiveness;Individual;Intervention;Knowledge;Leadership;Lived experience;Maintenance;Measurement;Measures;meetings;member;Mental Health;Mental Health Services;Methods;mobile application;model building;Modeling;Outcome;peer;peer support;Phase;Policies;Population;Practical Robust Implementation and Sustainability Model;prevent;Prevention;prevention service;preventive intervention;programs;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;referral services;Research;Resources;Sampling;satisfaction;sensor;Services;social;social determinants;social health determinants;social stigma;substance use;substance use prevention;Symptoms;System;Technology;technology intervention;Time;tool;Training;Training Programs;Trauma;trial design;trial planning;Underserved Population;uptake;volunteer;Vulnerable Populations;web site;Youth

PROJECT_TITLE: CASA and FostrSpace: Systems delivery of digital substance use prevention tools to foster youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-E (O1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Maternal Health;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Pre-pregnancy obesity has long been associated with indicators of impaired emotion regulation in children – e.g., increased rates of psychiatric disorders with emotion regulation deficits such as depressive and anxiety disorders. Our proposal aims to test the overarching mechanistic hypothesis that pre-pregnancy maternal obesity negatively influences emotion regulation and thus increases risk for psychopathology in children through its effects on the maternal gut microbiome and metabolome. The project will include the collection of demographic, clinical, behavioral, and neuroimaging data, as well as microbiome and metabolomic data.

PI_NAMEs: POSNER, JONATHAN E (contact);WANG, YUN

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Address;Affect;Age;Amygdaloid structure;Anxiety Disorders;Attention deficit hyperactivity disorder;Behavior;Behavioral;Behavioral Assay;Birth;Blood;Body mass index;Brain;brain magnetic resonance imaging;Child;Child Nutrition;Child Rearing;Clinical;Code;cohort;Cohort Studies;Collection;Data;Depressive disorder;design;Development;Diffusion;Discipline of obstetrics;Dopamine;Eating Disorders;emotion regulation;Emotional;Enrollment;Enzymes;epidemiology study;experience;Exposure to;Feces;fetal;First Pregnancy Trimester;Functional Magnetic Resonance Imaging;Genes;Genetic;gut microbiome;Health;high risk population;Hippocampus;Human;Impairment;in utero;Individual;Infant;Inflammation;innovation;Insula of Reil;Laboratories;Life;Link;longitudinal design;Low income;Magnetic Resonance Imaging;maternal microbiome;maternal obesity;maternal serum;maternal stress;Measures;Mediating;Mediation;Medical Records;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;metagenome;microbial;microbiome;Minority Groups;mood symptom;Mothers;mouse model;MRI Scans;multimodality;neurodevelopment;neuroimaging;neuropsychiatry;Obesity;Odds Ratio;offspring;Pathway interactions;Perinatal;Positioning Attribute;postnatal;pre-clinical;pre-clinical research;Prefrontal Cortex;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;prepregnancy;prepregnancy obesity;Prevention;Psychopathology;Research;Rest;Risk;Risk Factors;Rodent Model;Role;Sampling;Serotonin;sex;System;Temperament;Testing;Third Pregnancy Trimester;Time;tractography;Tryptophan;Tryptophan Metabolism Pathway;Tyrosine;Tyrosine Metabolism Pathway;Universities;Vertical Transmission;women versus men

PROJECT_TITLE: Prenatal maternal obesity and neurodevelopment: The mediating role of the microbiome and metabolome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

PHR: Project Narrative The proposed activities will position the GRAPHS cohort as a significant resource for expanding the environmental health sciences workforce in Ghana and beyond. In the long-term, this work will help inform cost-effective policies and public health interventions that may be applied to critical windows to promote optimal development and improve health.

PI_NAMEs: JACK, DARBY ;KAALI, SEYRAM ;LEE, ALISON G (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adolescence;Africa;African;Age;Air;Air Pollution;ambient air pollution;Archives;arm;Biological;Biological Markers;Birth;Blood Pressure;blood pressure reduction;Calibration;Cardiovascular Diseases;career development;Cessation of life;Child;Child Health;Climate;climate change;climate data;climate science;climate variability;cohort;Cohort Studies;Collection;Communities;community engagement;Community Participation;community partnership;comparison control;Consensus;Consent;cooking;Cookstove;cost;cost effective;critical period;Data;Data Analyses;Data Collection;data infrastructure;data management;data repository;data sharing;Databases;Development;disability-adjusted life years;disorder risk;early childhood;Education;Educational workshop;Environmental Exposure;Environmental Health;environmental justice;environmental stressor;Exposure to;feeding;Fetus;Fire - disasters;follow-up;Funding;Future;Gases;Ghana;Government;Growth;Health;health assessment;Health Benefit;Health Policy;Household Air Pollution;Hypertension;improved;infancy;Intervention;Knowledge;Lead;low and middle-income countries;Lung Diseases;Maintenance;male;Monitor;Mothers;Outcome;outreach;Participant;Particulate Matter;Persons;Petroleum;Play;Pneumonia;Policies;Positioning Attribute;postnatal;Predisposition;Pregnancy;prenatal;programs;public health intervention;pulmonary function;Randomized;Recontacts;repository;Research;Research Personnel;Resources;Risk;Role;Sampling;Science;Scientist;Shapes;shared repository;Smoke;Source;Specimen;Testing;tool;Woman;Work;Writing

PROJECT_TITLE: The Ghana Randomized Air Pollution and Health Study (GRAPHS) Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LKB-D (U2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH STATEMENT A major health challenge facing our society is a pervasive range of neurological disorders, which becomes more acute as our population ages. The goal of this project is to continue support of a summer residential research program at the University of Minnesota with the goal of inspiring new generations of bright, talented undergraduate students to enter neuroscience research as a career. The hope is that these future scientists will contribute to the health infrastructure by finding cures for these common, but devastating diseases of the nervous system.

PI_NAMEs: ARAQUE, ALFONSO  (contact);DUKES, ANGELINE JOAN;EBNER, TIMOTHY J;MEISEL, ROBERT L

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Age;Awareness;Biological Sciences;career;Career Choice;college;Data Analyses;Data Collection;Dedications;disabled;disabled students;disadvantaged background;disadvantaged student;Disease;economic disparity;Educational Curriculum;Educational workshop;effective therapy;Elderly;Evaluation;experience;Feedback;Functional disorder;Funding;Future;Future Generations;Generations;Goals;graduate school;graduate school preparation;Health;improved;Individual;Infrastructure;interest;Learning;Letters;Medical;Mentors;Minnesota;Modernization;Nervous System;Nervous System Disorder;Neurosciences;Neurosciences Research;novel therapeutics;peer;Persons;Population;posters;Process;programs;Public Health;Publishing;Puerto Rico;recruit;Recruitment Activity;Research;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Science;Scientist;skills;Social Interaction;Societies;Student recruitment;Students;success;summer program;summer research;symposium;Talents;Technical Expertise;Training;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: University of Minnesota Summer Research in Neuroscience

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hematology;Lung;Sleep Research;Social Determinants of Health

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative There is a critical need to expand the pool of diverse, clinician scientists who can combine personal and clinical perspectives with sophisticated research methodologies to advance health outcomes and reduce health disparities. The goal of the Columbia University Irving Medical Center (CUIMC) NHLBI Health Equity StARR Program is to identify, train, and retain a next generation of diverse physician scientists to advance health equity through health services, learning health systems, translational, basic science, and clinical research, focused on heart, lung, blood, and sleep diseases across the lifespan.

PI_NAMEs: TAYLOR, JACQUELYN Y (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Applied Research;Award;Basic Science;Black race;Blood;Cardiovascular Surgical Procedures;career;career development;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;college;Critical Care;design;Disadvantaged;disadvantaged background;Discipline;Disease;Disparity;disparity reduction;Ensure;Equity;Feedback;Funding;Future;Goals;Grant;hands-on learning;Health;health equity;Health equity research;health inequalities;Health Services;Health system;Heart;Heart Diseases;Hematological Disease;Hispanic;improved;Inequity;interest;Internal Medicine;Investments;Learning;life span;Lung;Lung Diseases;Medical center;medical schools;Mentors;Mentorship;Methodology;National Heart, Lung, and Blood Institute;next generation;Operative Surgical Procedures;Outcome;outcome disparities;outreach;Patients;Pediatrics;peer;people of color;Physicians;pressure;Professional Organizations;programs;Public Health Schools;recruit;Reduce health disparities;Research;research and development;Research Methodology;Research Personnel;Research Training;Residencies;Resources;School Nursing;Schools;Science;Scientist;skills;Sleep;Sleep Disorders;Social Work;Structure;Surgeon;Training;Training Support;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: The Columbia University Irving Medical Center (CUIMC) NHLBI Health Equity StARR Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O2)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: AMHERST

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Occupational noise-induced hearing loss is a major occupational disease resulting in tremendous socioeconomic and disease burden in industrial workers. In addition, these workers are exposed to chronic Manganese fumes by inhalation which results in a disease referred to as Manganism which will be addressed in the proposed study.

PI_NAMEs: KORDAS, KATARZYNA ;KRISHNAN MUTHAIAH, VIJAYA PRAKASH  (contact);WOOD, TROY D

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Hearing Loss by the Synergistic Effect of Chronic Inhalation of Exposure of Manganese Fumes with Occupational Noise Exposure

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Proper control of inflammation within the gastrointestinal (GI) tract is critical for human health, yet many aspects of how this is regulated remain unclear. We will investigate the role of small lipid extracellular vesicles called exosomes in conferring immune regulation in the GI tract during health and inflammatory disease. This work will contribute to the development of novel biomarker and therapeutic strategies for inflammatory bowel disease that involve exosomes and their cargo.

PI_NAMEs: O'CONNELL, RYAN M (contact);ROUND, JUNE LOUISE

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Anti-Inflammatory Agents;Binding;Cell Physiology;Cell secretion;cell type;Cells;Clinic;Colitis;Colon;Colon Carcinoma;commensal microbes;Communication;Complex;conditional knockout;Data;Dendritic Cells;Development;Disease;disease phenotype;Ensure;exosome;extracellular vesicles;Failure;Gastrointestinal tract structure;Genetic;Guanosine Triphosphate Phosphohydrolases;gut inflammation;Health;Heterogeneity;Human;human disease;Immune response;Immune system;Immunity;immunoregulation;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injections;insight;intercellular communication;Intestinal Diseases;intestinal homeostasis;Intestines;ITGAX gene;Knock-out;knockout gene;Knockout Mice;Learning;Lipids;Macrophage;Mediating;MicroRNAs;Modeling;Monomeric GTP-Binding Proteins;Mononuclear;Mouse Strains;mucosal site;Mucous Membrane;Multivesicular Body;Mus;Mutant Strains Mice;nanosized;novel;novel marker;novel therapeutic intervention;Nucleic Acids;pathogen;Pathway interactions;Patients;Phagocytes;Phenotype;Play;Population;Positioning Attribute;prevent;Prevention;Production;Proteins;Reaction;Reporter;Repression;response;RNA-Binding Proteins;Role;Sampling;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tissues;Translating;uptake;Vesicle;Work

PROJECT_TITLE: Immunoregulatory roles for exosomes in the gastrointestinal tract

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


NIH_SPENDING_CATS: Hematology

PHR: Project Narrative The Mount Sinai StARR program - NHLBI provides access to formative research experiences during residency training creating a novel onramp to physician scientist careers in heart, lung and blood research to enhance and diversify the pipeline of clinician investigators.

PI_NAMEs: CHU, JAIME C;GALLAGHER, EMILY JANE;KRAFT, MONICA  (contact);SHAH, NEOMI A

PROJECT_TERMS: Acceleration;Address;Aptitude;Award;Basic Science;Biomedical Research;Blood;Cardiology;career;career development;Child Health;Clinical;Clinical Research;Communicable Diseases;Competence;Data;design;Development Plans;Doctor of Philosophy;Educational Curriculum;Educational workshop;Ensure;Environment;equity, diversity, and inclusion;experience;Feedback;Fellowship;Fellowship Program;Fostering;Funding;Future;Goals;Grant;Health system;Heart;Heart Diseases;Hematological Disease;Hematology;Hypersensitivity;Immune System Diseases;Individual;interest;Internal Medicine;International;journal article;K-Series Research Career Programs;Laboratories;Literature;Lung;Lung Diseases;Medical Research;medical schools;Medicine;meetings;Mentors;Mentorship;Methodology;Mission;National Heart, Lung, and Blood Institute;National Research Service Awards;novel;Pathway interactions;pediatric department;Pediatrics;Peer Review;Physicians;Postdoctoral Fellow;Program Evaluation;programs;Publications;Pulmonology;Ramp;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Residencies;Rotation;Science;Scientist;success;Teacher Professional Development;theories;tool;Training;training opportunity;translational pipeline;Translational Research;translational research program;Underrepresented Minority;United States;United States National Institutes of Health

PROJECT_TITLE: Mount Sinai StARR Program - NHLBI


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed project applies innovative research methodology to four real-world databases to further elucidate the extent to which cognitive-behavioral correlates of reading comprehension act as risk- (deficits) vs. protective factors (strengths) for the development of poor reading comprehension in the face of adequate decoding (i.e., specific reading comprehension deficit) across the full distribution of readers. The current proposal aims to (1) investigate the nature of specific reading comprehension deficit in large representative samples of childhood and adolescent readers and (2) identify domain-specific, domain-general, and social skills-related correlates of specific reading comprehension deficit. Findings generated from this proposal have multiple implications for research, policy, and practice, including the ability to inform theoretical frameworks, hypotheses, and approaches aimed at understanding reading comprehension difficulties as well as develop more accurate identification methods, better prevention, and more efficacious intervention programs to effectively support children who struggle to comprehend text.

PI_NAMEs: SPENCER, MERCEDES  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 18 year old;Adolescence;Adolescent;Affect;Area;Attention;Behavioral;Child;Child Support;Childhood;Classification;Cognitive;comparative;Complex;comprehension deficit;comprehension skill;Databases;Development;Dyslexia;efficacious intervention;eighth grade;Eligibility Determination;Ensure;Etiology;executive function;Family;General Population;Glean;Impairment;innovation;intervention program;Knowledge;language comprehension;large-scale database;Learning Disabilities;Life;Mathematics;mathematics disability;Measures;Methods;Nature;novel strategies;Outcome;peer;Performance;phonology;Policies;Prevalence;Prevention;Procedures;Process;Prognosis;protective factors;Public Health;Reader;Reading;reading ability;reading comprehension;reading difficulties;recruit;remediation;Research;Research Methodology;Research Personnel;Risk;Sampling;screening;simulation;skills;social skills;Special Education;Tail;Testing;Text;Translating;trend;United States;Work;Writing

PROJECT_TITLE: Investigating the Unexpected Nature of Specific Reading Comprehension Deficit

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Genetics;Microbiome;Nutrition

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Paneth cell -defensins are antimicrobial peptides proposed to have two interrelated and fundamental functions: shaping the composition of the colonizing microbiota and contributing to innate immunity in the intestinal tract. These functions predict profound influence on human health. The proposed research will generate and characterize two complementary new mouse models to investigate Paneth cell -defensin function with a focus on the dramatic and physiologically driven intestinal changes that accompany maternal lactation, a critical but understudied window of mammalian biology.

PI_NAMEs: BEVINS, CHARLES L (contact)

PROJECT_TERMS: Address;alpha-Defensins;Animals;anti-microbial peptide;antimicrobial;Atherosclerosis;Automobile Driving;beneficial microorganism;Biological Models;Biology;Birth;Body System;Cell Physiology;Chromosome 8;Colon Carcinoma;Communities;Complex;constitutive expression;CRISPR/Cas technology;Data;Defensins;Diabetes Mellitus;dietary;Discipline;Discipline of Nursing;Disease;dysbiosis;Ecosystem;Effector Cell;Energy harvesting;Enteral;enteric infection;Epithelial Cells;Equilibrium;experimental study;Female;fitness;Fostering;Foundations;Future;Genes;Genetic;Genetic Models;Germ-Free;gut microbiota;Health;Health Promotion;Homeostasis;host microbiota;host-microbe interactions;Human;improved;in vivo Model;Individual;Infection;Inflammation;Injury;innovation;insight;Integration Host Factors;Intervention;Intestines;Knock-out;Knockout Mice;Laboratories;Lactation;Length;Life;Mammals;Mediating;Metabolic syndrome;Microbe;microbial community;microbiota;microbiota composition;Modeling;Molecular;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Names;Natural Immunity;novel;Nulliparity;Nutrient;Obesity;offspring;Paneth Cells;Pathogenesis;Peptides;Phenotype;physiologic model;Physiological;Physiological Processes;Physiology;Play;Predisposition;Pregnancy;Process;Production;Proteins;pup;Reproducibility;Reproductive Biology;Research;response;Role;Shapes;Signal Transduction;Site;Small Intestines;small molecule;Stimulus;Study models;Symbiosis;Time;Tissues;tool;transmission process;uptake;Weaning

PROJECT_TITLE: New mouse models to investigate host-microbe dynamics in physiology and innate immunity

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: HERSHEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Alzheimer’s disease (AD) shows progressive histological and behavioral hallmarks correlated with increased genomic instability. We will study the role of Y-family DNA polymerase, Pol kappa (Polk) that can bypass unstable DNA lesions to maintain cell survival in post-mitotic neurons in healthy aging and AD genotype condition. Now immunostaining data provide compelling rationale that neuronal Polk nuclear expression is correlated with aging and AD, hence we will identify its associated repair pathways in neurons, establish Polk interactomes in neuronal nuclei and investigate Polk's protective role in maintaining neuronal genomic stability.

PI_NAMEs: PAUL, SHILPI  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Active Sites;Age;age related;age related decline;aged;Aging;aging process;aging related;Alzheimer's Disease;Astrocytes;Base Excision Repairs;Behavioral;Biological Assay;Brain;Bypass;Cell Cycle;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Central Nervous System;combat;Data;Dependovirus;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Probes;DNA-Directed DNA Polymerase;DNA-PKcs;Face;Family;G0 Phase;Gamma-H2AX;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Genotype;Glial Fibrillary Acidic Protein;Goals;healthy aging;Histologic;Human Cell Line;Immunofluorescence Immunologic;Immunoprecipitation;Investigation;Lesion;Ligation;Lysosomes;Maintenance;Metabolic;Microglia;middle age;Mismatch Repair;Mus;Neurodegenerative Disorders;Neuroglia;Neuronal Differentiation;Neurons;Neuropathy;Nonhomologous DNA End Joining;novel;Nuclear;Nucleotide Excision Repair;old mice;overexpression;oxidation;p53-binding protein 1;Pathway interactions;Polymerase;postmitotic;prevent;protein biomarkers;Proteins;Proteomics;repaired;response;Role;Stains;stress granule;stressor;Structure;Testing;Transcription-Coupled Repair;Transgenes;validation studies;Work

PROJECT_TITLE: Role of Y-family DNA polymerase Pol kappa in aging and Alzheimer's disease

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Lung

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROGRAM NARRATIVE There is a pressing need for a diverse workforce of physician scientists who have the skillsets to conduct rigorous interdisciplinary scientific research and develop novel approaches for improving diagnosis and treatment of human disease. To this end, the Tulane StARR program will provide a mentored research and career development program for medicine and pediatric residents to increase the number and diversity of highly trained physician scientists in heart, lung, and blood diseases research. The program engages outstanding preceptors with established track records of mentoring and conducting highly meritorious research, and will foster the next generation of physician scientists able to make discoveries and translate discoveries into improved human health.

PI_NAMEs: KOLLS, JAY K;KROUSEL-WOOD, MARIE  (contact)

PROJECT_TERMS: Achievement;Address;American;Area;Basic Science;Blood;Board Certification;career;career development;Childhood;Clinic;Clinical;clinical care;Clinical Medicine;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;collaborative environment;Communication;community engaged research;Competence;COVID-19;Dedications;design;Development;Development Plans;Diagnosis;disabled;Diverse Workforce;Educational workshop;efficacy evaluation;efficacy research;Eligibility Determination;Engineering;Ensure;Environment;epidemiology study;equity, diversity, and inclusion;Evaluation;Exposure to;Faculty;Fellowship;Fostering;Funding;Future;Genetic;global health;Goals;Grant;Health;health equity;Heart;Heart Diseases;Hematological Disease;Human;human disease;implementation research;improved;Individual;innovation;Institution;Institutional support resources;Interdisciplinary Study;interest;Internal Medicine;Investments;Ions;Laboratories;Lead;Leadership;Learning;Lesbian Gay Bisexual Transgender Queer;life span;Lung;Lung Diseases;medical schools;medical specialties;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Modeling;Molecular;Monitor;National Heart, Lung, and Blood Institute;next generation;novel strategies;Pediatrics;Physicians;Population;Positioning Attribute;precision medicine;Prevention Research;Primates;Principal Investigator;Productivity;Program Development;Program Effectiveness;programs;Public Health;Qualifying;Records;recruit;Research;research and development;Research Methodology;Research Project Grants;Research Support;Research Training;Residencies;Resources;Rotation;Scholarship;Schools;Science;Scientist;Self Efficacy;Series;skills;social health determinants;Social Work;Strategic vision;Structure;success;Surveys;Time;time use;Training;Translating;Translational Research;Tropical Medicine;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Veterans;Wages;Woman;Wood material;Writing

PROJECT_TITLE: Tulane StARR Program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Patient Safety;Physical Activity;Physical Rehabilitation;Precision Medicine;Prevention;Rehabilitation;Sarcopenia

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Our study will inform novel appraisal of whether epigenetic age can be used to identify colon cancer patients at high risk for chemotherapy toxicity, dose reductions, and delays, and whether a resistance training intervention can reduce the rate of epigenetic aging, to mitigate that risk. Building on this analysis, we will evaluate whether epigenetic age can identify patients at greater risk for poor prognosis. We contend epigenetic age has the capacity to inform more personalized approaches to treating colon cancer patients to improve long-term outcomes.

PI_NAMEs: BINDER, ALEXANDRA MARGARET LYNN (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: accelerated epigenetic aging;Address;Adjuvant Therapy;Age;age acceleration;age-related disease;Aging;aging biomarker;aging process;aging related;Biological Assay;Biological Markers;Biological Process;biomarker validation;Blood;Body Composition;Body measure procedure;Body Size;Breast Cancer Treatment;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;Cell Aging;chemotherapy;Chemotherapy-Oncologic Procedure;Chronology;clinical care;Clinical Trials;cohort;Collaborations;Collection;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer treatment;comorbidity;Cyclin-Dependent Kinase Inhibitor 2A;Death Rate;Diagnosis;Diet;DNA Damage;DNA Methylation;Dose;drivers of aging;early onset;Early treatment;Educational Intervention;Epigenetic age;epigenetic aging;epigenetic clock;experience;Face;frailty;functional decline;Functional impairment;Health;health related quality of life;High Prevalence;high risk;improved;Incidence;Individual;insight;Intervention;Longevity;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;men;Modification;molecular subtypes;Morbidity - disease rate;mortality;multimodality;muscle form;Muscular Atrophy;novel;older adult;Outcome;Parents;Participant;patient prognosis;Patients;Pattern;personalized approach;Phenotype;Physical activity;physical conditioning;Physical Fitness;Physical Function;prevent;Prognosis;prognostic;rate of aging;rate of change;Recording of previous events;Recurrence;resistance exercise;Risk;risk minimization;risk mitigation;sarcopenia;Shapes;side effect;skeletal muscle wasting;Specimen;Syndrome;Telomerase;Thinness;Time;tool;Toxic effect;Toxicity due to chemotherapy;treatment as usual;Treatment-related toxicity;tumor;Tumor Tissue;United States;Woman

PROJECT_TITLE: Characterizing the Risk of Chemotherapy Side Effects Based on Epigenetic Age and Modification by Resistance Training Intervention


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

PHR: Project Narrative Patients with diabetes are at high risk for developing cognitive impairment and dementia. Yet, the exact mechanism underlying this link is not fully understood. The overall goal of this proposal is to study the role of insulin function in the brain in relation to preservation of brain structural and functional integrity in patients with diabetes.

PI_NAMEs: SABAYAN, BEHNAM  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: abeta deposition;Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Binding;Biological Markers;Blood;Blood specimen;Brain;brain health;brain volume;clinical imaging;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;cohort;Data;Dementia;diabetes management;Diabetes Mellitus;Disease;Dose;Early Diagnosis;Early Intervention;Exhibits;exosome;Experimental Animal Model;extracellular vesicles;Fasting;fluorodeoxyglucose positron emission tomography;follow-up;functional decline;functional disability;Functional disorder;Future;Glucose;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;gray matter;group intervention;Guidelines;high risk;Hippocampus;Hispanic;Hyperglycemia;Impaired cognition;Impairment;improved;Individual;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Link;Magnetic Resonance Imaging;male;Measures;Mediator;Memory impairment;Memory Loss;mild cognitive impairment;Modification;Molecular;Monitor;multi-ethnic;neuroimaging;neuroinflammation;neuron loss;Neurons;novel;Observational Study;older adult;older patient;Participant;Patients;Phenotype;Plasma;Population;pre-clinical;preservation;prevent;Prevention;receptor;Resources;response;Risk;risk stratification;Role;Sampling;screening guidelines;sex;Short-Term Memory;Signal Transduction;Speed;Structural defect;Structure;study population;targeted biomarker;tau-1;transmission process;trend;United States;white matter;women patients

PROJECT_TITLE: Plasma-Based Neuronal Insulin Signaling Exosomes as a Biomarker for Cognitive Impairment in Diabetes

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections

ORG_CITY: ALBUQUERQUE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Public Health Relevance/Project Narrative Human papillomaviruses (HPVs) are highly transmissible causative agents of benign and malignant tumors in mucosal and cutaneous squamous epithelium and pose significant health and economic burdens in the US and worldwide. Building on our finding that the inhibition of cellular MEK signaling suppresses papillomavirus early gene transcription, we plan to formulate and optimize MEK inhibitory drugs for the treatment of pathogenic papillomavirus infections. Successful completion of this work will position us to carry out clinical trials investigating MEK inhibitors as the first antiviral therapies for papillomavirus-induced diseases.

PI_NAMEs: OZBUN, MICHELLE A (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 3-Dimensional;Affect;American;Animal Model;Anogenital venereal warts;Anti-viral Therapy;Anus;Apical;Atopic Dermatitis;Basal Cell;Benign;Biochemical;Biology;Cancer Burden;cancer risk;Cervical;cervicovaginal;clinical application;Clinical Research;Clinical Trials;condyloma;Cutaneous;Data;Data Analyses;Development;Disease;Disease Progression;Dorsal;dosage;Drug Exposure;Drug Formulations;Drug Kinetics;Early Gene Transcriptions;Economic Burden;efficacy evaluation;efficacy testing;Epithelial Cells;Epithelium;FDA approved;Formulation;Frequencies;Gel;Gene Expression;General Population;Genetic Transcription;Genitalia;Genome;Genotype;Goals;Growth;Health;Histologic;HPV E7;Human;human model;Human papilloma virus infection;human papilloma virus oncogene;Human Papillomavirus;Immune;Immunocompetent;immunosuppressed;Immunosuppression;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infection;Infection prevention;Inflammatory;inhibitor;inhibitor therapy;innovation;Intraepithelial Neoplasia;Investigational New Drug Application;Lesion;Localized Lesion;Longevity;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Mediating;MEK inhibition;MEKs;Messenger RNA;Modeling;Morbidity - disease rate;mouse model;mucosal site;Mucous Membrane;Mus;Neoplasms;neoplastic;novel;Oncogenic;Oral;Oropharyngeal;Papillomavirus;Papillomavirus Infections;Pathogenicity;Penetration;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical development;premalignant;Prevalence;prevent;Preventive vaccine;Proteins;Pruritus;Psoriasis;public health relevance;Quality of life;Recurrence;Regimen;Regulation;Reporting;Respiratory Papilloma;response;Risk;Severities;Severity of illness;side effect;Signal Pathway;Signal Transduction;Site;Skin;skin disorder;Skin Neoplasms;Specificity;Squamous Epithelium;Surface;T-Lymphocyte;Testing;Therapeutic;tissue culture;Tissue Model;Tissues;Topical application;Toxic effect;tumor;Tumor Burden;tumor progression;Tumor Promotion;tumorigenesis;unvaccinated;Validation;Viral;Viral Physiology;virtual;Work

PROJECT_TITLE: Development of a novel anti-viral treatment for persistent HPV disease

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Daily continuous glucose monitoring (CGM) use is recommended for adults with type 1 diabetes (T1D) and can reduce the burden of diabetes management and improve health outcomes as a standalone tool and as a component of newer closed loop systems; yet, not everyone who adopts CGM sustains use over time. This project expands upon the parent K23 aims by applying mixed methods to investigate: remaining modifiable drivers of CGM discontinuation, including emotional distress; and factors associated with lower CGM usage and discontinuation. Results from these study aims will inform further optimization and tailoring of the ONBOARD intervention to promote sustained CGM use, which will in turn further maximize readiness for closed loop system adoption.

PI_NAMEs: TANENBAUM, MOLLY LEAH (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Abbreviations;Achievement;Address;Adopted;Adoption;Adult;aged;Algorithms;American;Attention;Behavior Therapy;career;Chronic Disease;Clinical;Complication;Continuous Glucose Monitor;Data;Data Analyses;Data Collection;Development;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Distress;Dose;emotional distress;follow-up;Glucose;glycemic control;Goals;Health;Health Benefit;Hypoglycemia;improved;Individual;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Insurance;Intervention;Investigation;Life;Link;longitudinal analysis;Longitudinal Surveys;Measures;Methods;Outcome;Parents;Participant;Patient Self-Report;post intervention;prevent;psychosocial;Psychosocial Factor;Quality of life;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Reporting;Research;Risk;Sampling;Sampling Studies;Self Management;social;System;Technology;Testing;Time;tool;Trust;uptake;Variant

PROJECT_TITLE: After ONBOARDing: Examining drivers of CGM discontinuation following a CGM uptake trial

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: NARRATIVE Our proposed research is relevant to public health and addresses NIH RFA-TR-22-030 for Investigating Understudied Proteins since we aim to generate an improved understanding of three chromodomain- helicase-DNA-binding (CHD) proteins that are understudied and implicated in multiple rare diseases including Chiari Malformation. We will use advanced cell-free expression techniques combined with microscale reaction volumes to generate functional wild type and disease related mutant CHD proteins. We will then begin structural characterization using cryo-Electron Microscopy and Native Mass Spectrometry to reveal their molecular similarities and differences that influence DNA binding and protein-protein interactions.

PI_NAMEs: EVANS, JAMES E (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;autism spectrum disorder;Binding;Binding Proteins;Biochemical;Cells;Characteristics;CHD7 gene;Chromatin Remodeling Factor;Collection;Coupled;Cryoelectron Microscopy;Diagnostic;Disease;DNA Binding;DNA-Binding Proteins;DNA-Protein Interaction;empowerment;Epilepsy;Escherichia coli;experimental study;Foundations;Funding Opportunities;Future;Gel;Genetic Transcription;Germ;Goals;Hela Cells;helicase;Hour;Human;improved;In Vitro;Individual;innovation;insight;Kinetics;Length;Life;Link;link protein;malformation;Mass Spectrum Analysis;Modeling;Molecular;molecular phenotype;mutant;Mutation;Nervous System Disorder;Outcome;Plasmids;Preparation;Protein Biosynthesis;Protein Family;protein protein interaction;protein structure;Proteins;Public Health;Rare Diseases;Reaction;Request for Applications;Research;Sampling;scale up;scoliosis;screening;Severities;Solubility;stoichiometry;Structure;success;Techniques;Testing;Tube;United States National Institutes of Health;Variant;Visual;Wheat;Work

PROJECT_TITLE: Researching understudied proteins of Chiari Malformation

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The Chemical Biology Training Program (CBTP) supports a robust and rigorous training environment for Ph.D. students drawn from the Departments of Chemistry and Molecular and Cell Biology at UC Berkeley. The program will train students in the use of chemical approaches to study and manipulate biological systems, preparing them for diverse academic and translational careers in biotechnology, pharmaceutical industries, and medicine. In addition to classroom teaching and hands-on research training, the program will engage the students in career development activities, establish internships with industrial partners, foster the advancement of diversity, equity, inclusion, and belonging, provide training in rigorous, reproducible, and responsible research, and build a culture of laboratory safety.

PI_NAMEs: FRANCIS, MATTHEW B (contact);MILLER, EVAN WALKER

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Biology;Chemicals;Training Programs

PROJECT_TITLE: Chemical Biology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Maternal Health;Maternal Morbidity and Mortality;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Rehabilitation;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: Project Narrative Anal (fecal) incontinence after childbirth is a significant public health problem estimated to affect 15-25% of women in the United States. This study aims to investigate whether a novel combination of neurotrophic and antifibrotic agents will prevent anal sphincter dysfunction in a preclinical animal model. These studies have a great potential for clinical translation to prevent childbirth injury related anal incontinence in women.

PI_NAMEs: RAJASEKARAN, MAHADEVAN RAJ (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: Acceleration;Accidents;Affect;Age;Anal canal;Anatomy;Animal Model;Animals;antifibrotic treatment;Anus;aspirate;axon regeneration;Brain-Derived Neurotrophic Factor;Childbirth;Circular layer of muscularis propria of anal canal;clinical translation;Combined Modality Therapy;Deposition;Development;efficacy evaluation;Electromyography;Evaluation;experience;External anal sphincter structure;Extravasation;FDA approved;Fecal Incontinence;Feces;Female;Fibrosis;Formulation;Functional disorder;functional improvement;functional outcomes;Gene Silencing;Genes;Goals;Growth;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Harvest;healing;high risk;Histologic;Impaired healing;Impairment;improved;In Vitro;in vivo;Incidence;Incontinence;injured;Injury;injury recovery;innovation;International;Intervention;Intramuscular;ionization;Laboratories;Length;lipid nanoparticle;Measurement;Mediating;Medical;middle age;Modeling;Molecular;Monitor;Morphology;multi-component intervention;multimodality;Muscle;Muscle function;muscle regeneration;myogenesis;Natural regeneration;Nerve;Nerve Crush;nerve injury;Nerve Regeneration;neural;Neurites;neuromuscular;neurotrophic factor;novel;novel strategies;novel therapeutic intervention;Oryctolagus cuniculus;Osmosis;Pathway interactions;Patients;Pelvic Floor Disorders;Pelvic Floor Muscle;Peripheral Nervous System;Physiological;Placebos;Population;Postpartum Period;pre-clinical;pressure;prevent;Prevention;Procedures;Protein Inhibition;Proteins;Public Health;Pump;receptor;Recovery;Recovery of Function;rehabilitation strategy;Reporting;Research;Rest;RNA;RNA vaccine;Role;screening;Signal Transduction;siRNA delivery;Site;Small Interfering RNA;Sphincter;sphincter ani muscle structure;Stenosis;Stretching;success;targeted treatment;Technology;Testing;Therapeutic;therapeutic protein;therapeutic target;Thick;Time;Tissues;translational potential;Trauma;ultrasound;United States;Up-Regulation;Validation;vascular injury;Vesicle;WNT Signaling Pathway;Woman

PROJECT_TITLE: Multimodal Interventions to Prevent Anal Sphincter Dysfunction After Childbirth-Related Neuromuscular Injury

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BIG EYE DIAGNOSTICS, INC.

PHR: PROJECT NARRATIVE WHO wants novel, highly sensitive, and ultra-specific lateral flow assays (LFA) to support its endeavors to eliminate onchocerciasis, a disease also known as river blindness affecting 18 million people, with another 218 million living at risk of contracting the disease. Onchocerciasis is fought by mass drug administration (MDA). WHO critically needs new diagnostic tests to support decisions to start and stop MDA programs and released in 2021 the corresponding desired target product profiles (TPPs). The most stringent TPP criterion is that the test must be extraordinarily specific (≥ 99.8%). Built in a novel biplex format, our test detects IgG4 antibodies specific to two antigens of O. volvulus, the causative pathogen of onchocerciasis. Our test already meets both TPPs and, remarkably, its specificity is >99.8% even at the lower bound 95% CI. Based on independent evaluation performed at CDC, which confirmed these results, USAID has already committed funding to evaluate the assay in the field on approximately 10,000 individuals. Given these exciting results, the massive relevance for public health, and the big momentum already garnered with key players (USAID, CDC, Task Force for Global Health), we are now requesting Direct-to-Phase II funding to swiftly progress the assay to manufacturing and commercialization.

PI_NAMEs: BIAMONTE, MARCO ANTONIO (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adopted;Adoption;Advisory Committees;Affect;Agency for International Development;Antibodies;Antigens;Binding;Biological Assay;Clinical Sensitivity;commercialization;commercialization readiness;Contracts;cost;cost effectiveness;Data;design;detector;Devices;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Ensure;Evaluation;field study;fighting;Friends;Funding;global health;Goals;Health;IgG4;improved;Individual;interest;Intestinal Volvulus;Investments;large scale production;lateral flow assay;manufacture;Manufacturer;manufacturing process;Marketing;meetings;National Institute of Allergy and Infectious Disease;Noise;novel;novel diagnostics;O Antigens;Ocular Onchocerciasis;Onchocerciasis;pathogen;Persons;Pharmaceutical Preparations;Phase;Prevalence;Process;programs;Protocols documentation;Public Health;public health relevance;Rapid diagnostics;Reagent;Recombinants;Recommendation;Reproducibility;Research;Risk;Sales;sample collection;Secure;Sensitivity and Specificity;Sister;Source;Specificity;Speed;Surveys;System;Testing;Time;tool;Tropical Disease;United States National Institutes of Health;Validation;Variant;Vendor

PROJECT_TITLE: SUPPORTING WHO ONCHOCERCIASIS ELIMINATION PROGRAMS: PROGRESSING A HIGHLY SENSITIVE AND ULTRA-SPECIFIC RAPID DIAGNOSTIC TEST TO COMMERCIALIZATION READINESS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: BROOKLYN COLLEGE

PHR: Epigenetic cancer therapies hold great promise as alternative treatment for a variety of human cancers. The present proposal attempts to develop chemical modulators of a key epigenetic regulator of gene transcription: the polycomb repressive complex 2. This complex of proteins is responsible for the methylation of lysine 27 at histone 3 (H3K27me3), a highly repressive histone mark whose dysregulation is strongly linked to a wide array of metastatic malignancies.

PI_NAMEs: GERONA-NAVARRO, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Alanine;alternative treatment;Amino Acids;amino group;analog;Antineoplastic Agents;Architecture;B-Cell Lymphomas;Binding;Biological Assay;cancer cell;Cancer cell line;cancer therapy;carcinogenesis;Catalytic Domain;Cell Line;Cell Proliferation;Cells;Chemicals;chemotherapeutic agent;chemotherapy;Chromatin;Clear cell renal cell carcinoma;Clinic;Clinical Data;clinical development;college;Complex;Data;Death Rate;design;Development;Disease;Dose;Drug resistance;efficacy evaluation;Epigenetic Process;experimental study;EZH2 gene;Family;Funding;Future;gain of function mutation;Gene Expression;gene repression;Gene Silencing;Genetic Diseases;Genetic Transcription;Goals;Grant;Health;histone methyltransferase;Histones;Human;Hyperactivity;Impairment;improved;in vivo;inhibitor;insight;interest;Intervention;Invaded;Knowledge;Laboratories;Lead;Link;Lysine;Malignant Epithelial Cell;Malignant Neoplasms;Measures;member;Metastatic Renal Cell Cancer;Methylation;Modification;Molecular;molecular dynamics;molecular targeted therapies;Mus;mutant;novel;Oncology;overexpression;Patients;Permeability;Polycomb;Preparation;programs;Proliferating;protein complex;Proteins;Quality of life;Recurrence;Regulator Genes;Renal Carcinoma;Reporting;Repression;Research;Research Project Grants;Resistance;Resistance profile;Role;Scanning;Secondary to;SET Domain;Side;Solid;stapled peptide;Structure-Activity Relationship;Therapeutic;therapeutic development;thioether;tumor;Tumor Suppressor Genes;tumorigenesis;Validation;Xenograft Model

PROJECT_TITLE: Allosteric Modulators of Polycomb Repressive 2 Gene Repression as Potential Therapeutics for the Development of Novel Epigenetic Cancer Therapies


NIH_SPENDING_CATS: Clinical Research;Genetics;Pediatric

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: NARRATIVE: Flaws in the immune system lead to immunodeﬁciency and autoimmune diseases. We propose combining quantitative genetics, experimental methods, and clinical samples to study the mechanisms of these ﬂaws and gain insights on how they impact immune-mediated diseases.

PI_NAMEs: MEYER, HANNAH VERENA (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Adult;Age;age related;Autoimmune Diseases;Back;Cell Communication;Cell Physiology;cell type;Cells;central tolerance;Childhood;Chromatin;Clinical;Complex;Data;Databases;Deficiency Diseases;design;Development;developmental genetics;Disease;Educational process of instructing;Effector Cell;Epithelial Cells;Equilibrium;Etiology;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic study;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Grain;Heritability;Human;Human Genetics;Immune;Immune system;Immune System Diseases;immunodeficiency;Immunologic Stimulation;Immunology;Inflammatory;innovation;insight;interest;Knowledge;Lead;Life;Link;Maps;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Methods;Molecular;Neonatal;novel;Nucleic Acid Regulatory Sequences;pediatric patients;Peripheral;Phenotype;Population;Predisposition;Proxy;public database;Quantitative Genetics;Quantitative Trait Loci;Regulation;Research;Resolution;response;Rest;RNA;Role;Sampling;Scientific Advances and Accomplishments;single-cell RNA sequencing;Specificity;Specimen;Stimulus;T-Cell Development;T-Lymphocyte;Techniques;Testing;Thymus Gland;Time;trait;Variant;Work

PROJECT_TITLE: Dissecting dynamic genetic effects from thymus development to immune-mediated disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance We have developed an efficacious intervention to promote physical activity adoption among breast cancer survivors. The intervention has been implemented successfully by peer mentors at the American Cancer Society. However, to reach more survivors and scale up the intervention so that it can be used by other cancer care organizations in the US that also have peer mentoring programs, we propose to adapt and modify our intervention (Moving Forward Together) using a web platform that has already shown success in supporting peer mentoring for medication adherence and dietary changes in other patient groups such as those with poorly-controlled diabetes.

PI_NAMEs: PINTO, BERNARDINE M. (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: 3-Dimensional;Accelerometer;acceptability and feasibility;Adoption;American;American Cancer Society;Award;Breast Cancer survivor;Businesses;cancer care;Cancer Survivor;Chronic Disease;Clinical;Collaborations;college;Colorectal Cancer;contextual factors;cost;Cost Effectiveness Analysis;Counseling;Country;Data;Data Collection;Diabetes Mellitus;dietary;Disease Management;Educational Intervention;efficacious intervention;Endometrial Carcinoma;Enhancement Technology;Ensure;Evaluation Studies;evidence base;Evidence based intervention;Exercise;exercise intervention;experience;Fatigue;Feedback;fitness;Foundations;Future;Goals;Health Insurance Portability and Accountability Act;HIV;Home;implementation facilitators;implementation trial;improved;indexing;interest;Intervention;intervention delivery;Interview;Learning;Letters;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Measures;medication compliance;Methods;Mission;Modeling;moderate-to-vigorous physical activity;Moods;new technology;Online Systems;Outcome;Patient Self-Report;Patients;peer coaching;peer support;personalized approach;Persons;Phase;Physical activity;Physical Function;Positioning Attribute;post intervention;Practical Robust Implementation and Sustainability Model;pragmatic implementation;pragmatic trial;primary outcome;Process;programs;psychosocial;public health relevance;Quality of life;Randomized;randomized controlled design;randomized, controlled study;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;recruit;Research;Resources;Risk Reduction;scale up;Site;Small Business Innovation Research Grant;Speed;Sports Medicine;Structure;success;Suggestion;Supervision;Survivors;System;Telephone;Testing;theories;Time;Training;Training Programs;user centered design;web platform;Work

PROJECT_TITLE: Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors:  Adapting an Efficacious Intervention to Prepare for Implementation

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Hypertension;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative Endothelial cells regulate arterial contractility. Dysfunctional endothelial cell control of contractility is a hallmark of several cardiovascular diseases, including hypertension, but pathological mechanisms involved are poorly understood. We will investigate the novel hypothesis that PKD1 and PKD2 proteins regulate arterial contractility, investigate signaling mechanisms involved and test the concept that vasodilation mediated through these pathways is dysfunctional during hypertension.

PI_NAMEs: JAGGAR, JONATHAN H (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acetylcholine;Arteries;Attenuated;autocrine;Biotinylation;Blood flow;Blood Pressure;Blood Vessels;Calcium;Calcium Signaling;Calcium-Activated Potassium Channel;Cardiovascular Diseases;Cell Line;Cell Physiology;cell type;Cell Wall;Coupling;Data;Electrophysiology (science);Endothelial Cells;Endothelium;Fluorescence Resonance Energy Transfer;Genetic Models;Hypertension;Image;Immunofluorescence Immunologic;Impairment;Knock-out;Knockout Mice;Ligands;Light;Lighting;Mediating;Membrane Potentials;Methods;Microscope;mimetics;Modification;Mus;Myography;Nitric Oxide Synthase;novel;Organ;patch clamp;Pathologic;Pathway interactions;pharmacologic;Physical Stimulation;Physiological;PKD2 protein;polycystic kidney disease 1 protein;Process;protein kinase D;protein phosphatase inhibitor-2;Proteins;Receptor, Angiotensin, Type 1;Regulation;Resistance;response;Reverse Transcriptase Polymerase Chain Reaction;RNA Interference;Signal Transduction;Stimulus;Superoxide Dismutase;Systemic blood pressure;Telemetry;Tertiary Protein Structure;Testing;Transmembrane Domain;TRP channel;Vasodilation;Vasodilator Agents;Western Blotting

PROJECT_TITLE: PKD proteins in endothelial cells

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Heart Disease;Patient Safety;Prevention;Primary Health Care

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Public Health Relevance Survivors of early-stage cancers are susceptible to cardiovascular disease due to pre-existing cardiovascular risk factors and receipt of potentially cardiotoxic cancer treatments. Our automated electronic health record (EHR)-based tool addresses the growing burden of cardiovascular disease among cancer survivors in the United States by empowering oncologists to discuss cardiovascular health with their patients and facilitating appropriate care for cardiovascular disease risk factors. In this study, we will test whether our pragmatic EHR-based cardiovascular health tool – which incorporates patient risk factor and cancer treatment data – will improve cardiovascular health discussion, completed visits, and cardiovascular risk factors in a real-world setting, with the ultimate goal of improving cancer survivors' morbidity and mortality. 1

PI_NAMEs: FORAKER, RANDI E;WEAVER, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BUSCETTA, ASHLEY JIN

PROJECT_TERMS: Address;Adoption;Aftercare;anti-cancer research;Assessment tool;Awareness;Behavior;Blood Pressure;Body mass index;Breast;cancer recurrence;Cancer Survivor;cancer therapy;Cardiac health;Cardiology;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care coordination;Caring;Cause of Death;Cholesterol;Clinic;clinical decision support;clinical examination;Colorectal;Colorectal Cancer;Communities;Community Clinical Oncology Program;comorbidity;Data;Diet;effectiveness/implementation study;efficacy evaluation;Electronic Health Record;Electronics;empowerment;Endometrial;Endometrial Carcinoma;Enrollment;Evaluation;Future;future implementation;Glucose;Glycosylated hemoglobin A;Goals;Health;health application;health assessment;Health behavior;Health Promotion;health record;high risk;improved;Inflammation;Informatics;Intervention;intervention delivery;Interview;lifestyle factors;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Methods;Modification;Morbidity - disease rate;mortality;novel;Obesity;Oncologist;Oncology;Outcome;Patient risk;Patients;Physical activity;point of care;Population;Predisposition;Preventive care;Primary Care;primary care provider;primary care services;primary care setting;Process;programs;Prostate;prototype;Provider;public health relevance;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Risk;Risk Factors;Risk Reduction;routine practice;side effect;Smoking;Speed;Structure;support tools;Survivors;survivorship;Technology;Testing;Tobacco;tool;Translations;treatment as usual;trial design;United States;usability;Visit;Visual;Weight Gain

PROJECT_TITLE: Assessing efficacy and implementation of an EHR tool to assess heart health among survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NRCS-V(08)]


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE Oklahomans, on average, suffer from poor health combined with lower educational attainment. There is a need to expand scientific education at all levels, with a particular need to train a diverse cadre of doctoral students who can assume university-level faculty positions, and thus serve as role models and mentors for younger students. The Post-Baccalaureate Research and Education Program focuses on recruiting and training promising, under-represented students so that they can be competitive for admission into biomedical doctoral programs, and ultimately become skilled scientists and advocates for a scientific approach to decision-making.

PI_NAMEs: HOWARD, ERIC W (contact);TSIOKAS, LEONIDAS

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Admission activity;Advocate;animal care;Animals;Bachelor's Degree;Basic Science;Biomedical Research;biomedical scientist;Biometry;career;career development;Categories;Clinical Sciences;cohort;college;Communities;Contracts;course development;Data Analyses;Decision Making;Disparity;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational process of instructing;Educational workshop;experience;experimental analysis;Experimental Designs;Exposure to;Extramural Activities;Faculty;Foundations;Funding;Goals;Graduate Education;graduate student;Grant;Health;health disparity;health science research;Health Sciences;higher education;Immersion;improved;Individual;Industry;Institution;interest;Interview;Journals;Knowledge;Laboratory Research;lectures;Life;Mentors;Methods;Monitor;Native Americans;Oklahoma;Outcome;Outcomes Research;Participant;Partnership Practice;Persons;Population;Positioning Attribute;Postbaccalaureate;Process;programs;recruit;recruitment science;Reporting;Reproducibility;Research;Research Methodology;Research Project Grants;Resources;responsible research conduct;role model;Rotation;Science;science education;scientific literacy;Scientist;skills;social media;Student recruitment;Student Selections;student training;Students;success;System;Technology;Time;tool;Training;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States;Universities;Visit;web site;Work

PROJECT_TITLE: Post-Baccalaureate Research and Education Program (PREP) for Oklahoma

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The purpose of the NIDDK R25 Research Education Training Program, DULCE (Diabetes InqUiry through a Learning Collaborative Experience) at the University of Chicago (UC) Pritzker School of Medicine (PSOM) is to inspire medical students to pursue careers in diabetes mellitus (DM) research through exposure to the full continuum from basic science to translational DM research and the interdisciplinary collaboration needed to care for patients with DM.

PI_NAMEs: BAIG, ARSHIYA AHMED (contact);CHIN, MARSHALL H

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Admission activity;Adult;African American;American;Area;Attitude;Basic Science;Black race;Caliber;career;Caring;Chicago;Clinical;clinical care;clinical practice;Clinical Research;clinical translation;Communities;Community Health;cost;Dedications;Diabetes Mellitus;digital technology;education research;effectiveness evaluation;Enrollment;ethnic minority;Evaluation;experience;Exposure to;Funding;Future;Goals;Grant;health disparity;Health Occupations;Home;improved;Inequity;innovation;Insulin;Intention;interdisciplinary collaboration;interest;Latinx;Learning;medical schools;medical specialties;Medical Students;meetings;Mentors;Modeling;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;novel strategies;Patient Care;Patients;peer;Peer Review;Physicians;Policies;Policy Research;Population;Productivity;programs;public database;Publications;racial minority;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Role;Scientist;Self Efficacy;Series;Structure;student training;Students;summer research;symposium;Technology;theories;Therapeutic;Training;Training Programs;Translational Research;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: DULCE (Diabetes InqUiry Through a Learning Collaborative Experience)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative The public health relevance of this project lies in its comprehensive approach to studying the genetic and sociocultural contributions to the development of childhood and adolescent sleep and health in an ethnically and socioeconomically diverse sample. The results yield a better, genetically-informed understanding of developmental pathways among sleep and health during puberty to identify dynamic processes that longitudinally predict mental health and inflammation. The knowledge to be gained informs intervention and prevention through identification of modifiable targets that impact adolescent sleep and health.

PI_NAMEs: DOANE SAMPEY, LEAH DARRAH (contact);LEMERY-CHALFANT, KATHRYN

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Accounting;Acute;Address;Adolescence;Adolescent;Adolescent Development;Adult;Aerobic;Affect;Age;Anxiety;Arizona;Biological;Biological Markers;Birth Records;Characteristics;Child;Child Welfare;Childhood;Cognition;Collaborations;Communities;Complex;conduct problem;Data;design;Development;Developmental Process;Diagnosis;Disease;Emotional;Environment;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Exhibits;experience;Genes;Genetic;genetic approach;Genetic Models;Genetic Risk;Genetic study;Goals;Growth;Health;health disparity;Health Psychology;Heritability;Home;Hydrocortisone;inattention;infancy;Inflammation;Inflammatory;Intercept;Intervention;Knowledge;Link;Measurement;Measures;media use;Mediating;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;mortality;Muscle;novel;Obesity;Outcome;Outcome Assessment;Pathway interactions;Pattern;perceived stress;physical conditioning;Physiological;Physiological Processes;Physiology;poor sleep;Prevention;preventive intervention;Process;pubertal timing;Puberty;public health relevance;recruit;Reporting;Research;resilience;Risk;Risk Factors;Role;Sampling;Sleep;Sleep Disorders;sleep health;sleep quality;social;social culture;social media;socioeconomic disparity;socioeconomics;Specific qualifier value;Specificity;Stress;substance use;Symptoms;Twin Multiple Birth;Twin Studies;Weight;Work;Youth

PROJECT_TITLE: Social and Genetic Contributions to Children's Sleep, Health and Functioning


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH: Our studies are relevant to the development of vascular calcification (“hardening of the arteries”), which is a frequent and clinically important complication of vascular disease. The goal is to understand how the so-called endothelial cells, derived from capillaries and the inner lining of vessels, contribute to the formation of calcified vessels. Such understanding may be used to develop new strategies to specifically target the endothelial cells in limiting vascular calcification.

PI_NAMEs: BOSTROM, KRISTINA I (contact)

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Aorta;Appearance;Area;Arteries;Blood capillaries;bone;calcification;Cardiovascular Diseases;Cartilage;CD34 gene;Cell Lineage;Cell Maintenance;Cells;Chondrocytes;Clinical;Complication;Development;Disease;Endothelial Cells;endothelial-specific sialomucin;Endothelium;experimental study;Gene Deletion;Gene Expression Profile;Glycoproteins;Goals;Growth;Human;In Vitro;in vivo;inhibitor;Intervention;Knockout Mice;Location;matrix Gla protein;Mesenchymal;Modeling;Morbidity - disease rate;mortality;Mus;notch protein;novel;Operative Surgical Procedures;Osteogenesis;osteogenic;osteoprogenitor cell;Pathology;PECAM1 gene;Peripheral;Play;Population;postnatal;Predisposition;Prevention;Public Health;receptor;recruit;Regulation;RNA analysis;Role;Sampling;Severities;Side;Signal Transduction;single-cell RNA sequencing;stem cells;Supporting Cell;Testing;therapy development;transcription factor;treatment strategy;Tunica Adventitia;Vascular calcification;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Endothelium

PROJECT_TITLE: Endothelial Regulation of Vascular Calcification

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Hyperactive signaling by the G protein ? q subunit (G? q) is known to contribute to cardiac hypertrophy and heart disease, the latter of which is the leading cause of death in the developed world. This proposal will investigate how G? q signaling leads to cardiac hypertrophy by (1) probing for novel target proteins downstream of G? q and (2) determining whether any of these targets are involved in cardiomyocyte hypertrophy or apoptosis. These efforts will afford valuable insights into G? q signaling and may inform therapeutic strategies against heart disease.

PI_NAMEs: LOOMIS, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Adenoviruses;ADRBK1 gene;Adrenergic Agents;Angiotensin II;Animal Model;Apoptosis;Attenuated;Biological Assay;Biophysics;Biotin;Biotinylation;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Cell Physiology;Cell Surface Receptors;Cells;Chromatin Remodeling Factor;Co-Immunoprecipitations;Communities;Coupled;Development;Diglycerides;Disease;Endothelin A Receptor;experimental study;Family;follow-up;Functional disorder;Future;G alpha q Protein;G-Protein-Coupled Receptors;GTP-Binding Proteins;Guanosine Triphosphate;HDAC9 gene;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heterotrimeric GTP-Binding Proteins;Human;Hydrolysis;Hyperactivity;Hypertrophy;In Vitro;in vivo evaluation;Inositol;insight;knock-down;Knock-out;Label;Laboratories;Lead;Ligase;Link;Mass Spectrum Analysis;Measures;Mediating;Mediator;Molecular;Mus;novel;Pathology;Phenylephrine;Phosphatidylinositols;phospholipase C beta;Phospholipases A;Physiological;Play;pressure;Protein Array;Protein Isoforms;Protein Kinase C;Proteins;Proteomics;Radiolabeled;Rattus;receptor;reconstitution;Regulation;Research;response;Role;screening;Signal Pathway;Signal Transduction;Small Interfering RNA;SMARCD3 gene;Stimulus;Streptavidin;System;Testing;Therapeutic;tripolyphosphate;Variant;Work

PROJECT_TITLE: Identifying Novel Signaling Mechanisms Downstream of Cardiac Gq-Coupled Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: More than half of all proteins in nature are decorated or modified by sugar structures called ‘glycans’. This project aims to collect a vast amount of molecular data related to biological and biochemical processes that regulate cellular glycosylation, and to organize these in a query-able computational framework. Such studies aim to outline the fundamental mechanisms regulating glycosylation in blood cells participating in innate immunity, and related leukocyte-endothelial cell adhesion processes.

PI_NAMEs: NEELAMEGHAM, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Abbreviations;Address;Adhesions;Anabolism;Animals;Atlases;Bar Codes;Basic Science;Binding;Biochemical Pathway;Biochemical Process;Bioinformatics;Biological Assay;Biological Markers;Biological Process;Blood;Blood Cells;carbohydrate binding protein;carbohydrate receptor;CD34 gene;Cell Adhesion;Cell Adhesion Molecules;Cell Adhesion Process;Cell Line;Cell Physiology;Cells;Cellular Metabolic Process;Clinic;clinical diagnostics;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Computational Biology;computer framework;Computers;cost;Coupling;CRISPR library;CRISPR screen;Data;Development;Disease;disease diagnostic;Ear;Early Diagnosis;Endothelial Cells;Enzymes;Epigenetic Process;Event;Experimental Models;Family;Flow Cytometry;Fucose;Funding;Galactose;Gene Expression Profile;Gene Mutation;Gene Targeting;Genes;Genetic;genome-wide;Glycoconjugates;glycoproteomics;glycosylation;glycosyltransferase;Grant;granulocyte;Hematopoietic;Hematopoietic stem cells;Hemorrhage;HL60;Human;Immunity;in vivo;Individual;Inflammation;Inflammatory;inhibitor;Knock-out;Knowledge;Lead;Lectin;Leukocytes;Libraries;Link;Macrophage;Mammalian Cell;Maps;Mass Spectrum Analysis;Measurement;Measures;Mechanics;Mediating;Methods;Microfluidics;model building;Modeling;Molecular;molecular scale;monocyte;Mononuclear;Mus;Myelogenous;Myeloid Cells;National Heart, Lung, and Blood Institute;Natural Immunity;Nature;Neoplasm Metastasis;network models;neutrophil;next generation sequencing;Nomenclature;novel;Organism;outcome prediction;Pathway interactions;patient stratification;Pattern;peripheral blood;Polysaccharides;Post-Translational Protein Processing;precision medicine;programs;Proteins;relational database;Role;Selectins;sequencing platform;Series;Sialic Acids;sialyl Lewis x;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;small molecule;small molecule inhibitor;Specificity;Structure;sugar;System;Systems Biology;Technology;Testing;tool;Transcript;transcription factor;transcriptome;transcriptomics;Translating;Transplantation;user-friendly;Vascular Endothelial Cell;web site;Work

PROJECT_TITLE: Systems Biology of Glycosylation

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Medulloblastoma is a common and highly malignant childhood brain tumor. Although current therapies are effective in some patients, over 70% of the MB patients with GLI2-amplification suffer from tumor relapse that eventually leads to death. In this application, we propose identifying the underlying mechanisms of tumorigenesis and developing novel and focused therapeutic approaches to combat this devastating disease effectively.

PI_NAMEs: PEI, YANXIN  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: aged;Automobile Driving;Cells;Cerebellum;Cessation of life;Child;Childhood Malignant Brain Tumor;Clinical;combat;Combined Modality Therapy;Cytoplasmic Granules;Data;design;Development;Disease;Doxycycline;Early Diagnosis;effective therapy;efficacy evaluation;Embryo;Engineering;fighting;genetic signature;GLI2 gene;Goals;granule cell;Growth;Human;improved;in vivo;inhibitor;Internal Ribosome Entry Site;loss of function mutation;Malignant neoplasm of brain;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;Mathematics;Medulloblastoma;MEKs;Modeling;Molecular;Molecular Profiling;mouse model;Mouse Strains;Mus;Mutation;MYCN gene;nerve stem cell;novel;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;pharmacologic;Phase;Phosphorylation;Population;prevent;Prognosis;Relapse;relapse prevention;Resistance;Resistance development;response;Role;SHH gene;Signal Transduction;single-cell RNA sequencing;spatiotemporal;stem cells;Subgroup;survival outcome;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;Time;TP53 gene;transcription factor;Transforming Growth Factor beta;Transgenic Mice;Treatment outcome;tumor;tumor growth;tumor progression;tumor xenograft;Tumor-Derived;tumorigenesis;Work

PROJECT_TITLE: Oncogenic mechanisms underlying GLI2-amplified medulloblastoma


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Data Science

ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: There is a nationwide shortage of biostatisticians. This shortage is negatively impacting research in the medical, biomedical and public health sciences. This project aims to introduce talented undergraduate students to biostatistics, and encourage their entry into graduate schools in biostatistics to subsequently pursue careers in biostatistics, statistics and data sciences.

PI_NAMEs: ZAMBA, GIDEON D (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Academia;Admission activity;Articulation;Artificial Intelligence;Big Data;Biological Sciences;Biomedical Research;Biometry;career;case-based;Case/Control Studies;Clinical Research;college;Computers;Data;Data Science;design;disadvantaged student;Doctor of Philosophy;Drug Industry;education research;Educational Curriculum;experimental study;Exposure to;Faculty;faculty mentor;Goals;Graduate Degree;graduate school;graduate student;Health Sciences;improved;Industry;innovation;Institution;Instruction;interest;Iowa;laboratory experience;mathematical sciences;Medical;Medical Students;member;Mentors;Minority;Modeling;programs;Public Health;recruit;Research;Research Institute;Research Personnel;skills;Solid;statistics;Student Selections;Students;summer institute;summer research;symposium;Talents;Translational Research;undergraduate education;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;university student;Vision

PROJECT_TITLE: (Iowa ISIB) Summer Institute for Research Education in Biostatistics and Data Science


NIH_SPENDING_CATS: Bioengineering;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will create a new approach to building model tissues of the kidney based on the engineering rules governing kidney development. Once such model tissues are developed, they will spur significant advances in regenerative medicine. The proposed research is especially relevant to one of the NIH’s “Transformative Technologies” goals, which specifically highlights new engineering approaches to building kidney tissues that will contribute to reducing illness and disability related to kidney disease.

PI_NAMEs: HUGHES, ALEX  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Adult;Area;Autologous;Biocompatible Materials;Biological;biophysical properties;bioprinting;Body System;cell assembly;cell community;Cell Lineage;Cells;Chronic Kidney Failure;Coculture Techniques;Complex;Data;Development;Dialysis procedure;disability;Disease;Donor person;Drainage procedure;Drug Targeting;Duct (organ) structure;Economic Burden;End stage renal failure;Engineering;Epithelium;Event;Fetal Kidney;Filtration;Future;Goals;Human;human induced pluripotent stem cells;human pluripotent stem cell;human tissue;Immunocompromised Host;innovation;Invaded;Kidney;Kidney Diseases;Knowledge;Literature;Location;Lung;Mammary gland;Mechanics;Mesenchymal;Mesenchyme;model building;Morbidity - disease rate;Morphogenesis;Mus;nephrogenesis;Nephrons;novel strategies;optogenetics;Organ;Organ Transplantation;Organoids;Outcome;Pathology;Patients;Pattern;Population;Positioning Attribute;Prevalence;Process;programs;Prostate;Public Health;Quality of life;Regenerative Medicine;regenerative tissue;Renal Tissue;Research;screening;Site;Solid;spatiotemporal;Specific qualifier value;spheroids;stem cells;Structure;Surface;System;Technology;Tissue Model;Tissues;Transplantation;United States National Institutes of Health;urinary;Urine;WNT Signaling Pathway;Work

PROJECT_TITLE: Engineering induction and assembly of human kidney tissue

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) Our studies are directly relevant to the missions of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fertility and Infertility Branch “to encourage, enable, and support scientific research aimed at alleviating human infertility, uncovering new possible pathways to control fertility, and expanding fundamental knowledge of processes that underlie human reproduction” and the NICHD Contraception Research Branch to develop “new and improved methods of contraception”. Despite the abundance of genes expressed in post-natal male germ cells (~4% of the mammalian genome), the functions of many of these genes and the pathways through which they act remain unknown. To address this deficiency and respond to the NICHD Strategic Plan 2020, our R01 renewal proposal will focus on placing six male fertility-essential proteins into molecular, biochemical, and genetic pathways “to understand human development”, translate this information to “improve reproductive health” by enabling the diagnosis and treatment of conditions in which these pathways are disrupted in men, and apply this knowledge to develop novel non-hormonal male contraceptives.

PI_NAMEs: MATZUK, MARTIN M. (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Academia;Address;Affinity;Antibodies;Area;Bar Codes;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biology;Biotin;Chemicals;Chemistry;Contraceptive Agents;Contraceptive methods;contraceptive target;CRISPR/Cas technology;design;Development;Diagnosis;DNA;DNA Sequence;drug discovery;Drug Targeting;drug-like compound;economic need;Epididymis;Epitopes;FDA approved;Fertility;Fertility Disorders;gene product;Generations;Genes;Genetic;genetic manipulation;Genome engineering;Goals;GPI Membrane Anchors;Grant;high throughput screening;Human;Human Development;improved;In Vitro;in vivo;Infertility;Informatics;inhibitor;insight;Integral Membrane Protein;Knock-out;Knockout Mice;Knowledge;Libraries;Ligation;male;Male Contraceptive Agents;male fertility;mammalian genome;Mammalian Oviducts;Mediating;Membrane;men;Methods;migration;Mission;Molecular;Molecular Biology;Molecular Mechanisms of Action;mouse genome;mouse model;Mus;Mutate;National Institute of Child Health and Human Development;novel;Paper;Pathway interactions;Peptide Hydrolases;Pharmacologic Substance;postnatal;prevent;Process;Protein Secretion;Proteins;Proteomics;public health relevance;Reproduction;reproductive;Reproductive Biology;Reproductive Health;reproductive tract;Research;Science;screening;small molecule;small molecule libraries;Specificity;sperm cell;sperm function;Sperm Maturation;Spermatocytes;Spermatogenesis;Spermiogenesis;Sterility;Strategic Planning;Structure;subfertility;Technology;Testing;Testis;Toxic effect;Translating;Tube;Uterus;Validation;validation studies;Vision

PROJECT_TITLE: Functional analysis of novel testis-expressed secreted and transmembrane proteins

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative: This project will develop novel biocatalytic systems and strategies useful for the preparation of optically active building blocks and molecules of direct value for medicinal chemistry and drug discovery campaigns. As such, the methodologies and catalysts developed over the course of this research are expected to facilitate the synthesis, discovery, and/or manufacturing of therapeutically relevant molecules for the treatment of human disease.

PI_NAMEs: FASAN, RUDI  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Metalloprotein catalysts for asymmetric synthesis

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PI_NAMEs: OLIVA GONZALEZ, AZAHARA  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Hippocampal-subcortical interactions underlying social memory

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Our goal is to understand the recognition of nucleic acids inside cells. One focus will be RNA- mediated recognition in cell nuclei. We will use our understanding of mechanism to develop new methods to control expression of genes involved in disease, including the genes responsible for Friedreich's Ataxia and Fuchs' Dystrophy.

PI_NAMEs: COREY, DAVID R (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Area;Biological Process;Biological Response Modifier Therapy;Cell Line;Cell Nucleus;Cell Physiology;Cells;Cellular biology;cellular targeting;Chemicals;Chemistry;Complex;Corneal Endothelium;crosslink;Cytoplasm;Degenerative Disorder;Disease;drug development;Family;Friedreich Ataxia;Fuchs' Endothelial Dystrophy;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Human;Immunoprecipitation;insight;Knock-out;Laboratories;Mass Spectrum Analysis;Mediating;Medicine;Methods;MicroRNAs;Modification;mutant;novel;Nuclear;nucleic acid structure;Nucleic Acids;Oligonucleotides;patient population;Peer Review;Pharmaceutical Preparations;Proteins;Publications;Regulation;RNA;RNA Interference;RNA Splicing;Role;synthetic nucleic acid;therapeutic development;tool;transcriptome sequencing;Translations;Trinucleotide Repeats;Untranslated RNA;Validation;Work

PROJECT_TITLE: Recognition of Cellular Targets by single and double-stranded nucleic acids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]