NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Genetics;Prostate Cancer;Radiation Oncology;Urologic Diseases

PHR: Absorbed dose will better predict patient response to alpha-particle emitter radiopharmaceutical therapy (αRPT) when adjusted by quantitative measures of DNA DSB repair pathway functionality. We introduce a novel approach to assessing repair pathway functionality and couple it with preclinical and clinical scenarios that will allow us to rigorously evaluate the impact of accounting for DSBR functionality in relating absorbed dose to response. We will test our hypothesis in a context that is immediately clinically relevant by using prostate cancer patients already treated with 223RaCl2 (Xofigo), an FDA approved, αRPT

PI_NAMEs: SGOUROS, GEORGE  (contact)

PROJECT_TERMS: absorption;Accounting;advanced prostate cancer;Affect;Alpha Particle Emitter;anti-PSMA;Beta Cell;Beta Particle;Biological;Biological Models;bone;Bone Marrow;BRCA2 gene;Cancer Patient;cancer therapy;Cell Communication;cell killing;Cell Line;Cell Proliferation;Cells;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;Complement;Coupling;Data;Dependence;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;Dose;dosimetry;Double Strand Break Repair;Evaluation;Exposure to;Family suidae;FDA approved;FOLH1 gene;genomic profiles;Genomics;Germ Lines;Growth;Hematopoietic;homologous recombination;Human;Image;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;Kidney;Leukocytes;liquid biopsy;Malignant neoplasm of prostate;Marrow;mathematical model;Measurement;Measures;Metastatic Neoplasm to the Bone;Methods;Modeling;Molecular;monolayer;Mus;Mutation;mutational status;Normal tissue morphology;novel;novel strategies;Organ;Pathway interactions;patient response;Patients;Peripheral;Photons;pre-clinical;predicting response;Process;Property;prostate cancer cell;prostate cancer cell line;Proteomics;radiation effect;Radiation Tolerance;Radiobiology;Radiopharmaceuticals;Radium;repaired;response;Role;Sampling;Schedule;simulation;Small Intestines;small molecule;spheroids;Techniques;Testing;Time;Tissues;Toxic effect;transcriptomics;Treatment Efficacy;treatment planning;treatment response;Treatment-related toxicity;tumor;tumor growth;Tumor Tissue;tumor xenograft;Variant;Work;Xenograft procedure

PROJECT_TITLE: Radiobioeffect Modeling of αRPT


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Genetics;Rare Diseases;Tuberous Sclerosis

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project 1 – Narrative In this project, we seek to identify novel therapeutic approaches to selectively and safely eliminate tumor cells with aberrant activation of a common cancer-causing biochemical pathway that contributes to the development and progression of both inherited tumor syndromes and the most common forms of cancer. This project lies at the heart of a larger research program to identify and test new therapies for a broad array of human cancers.

PI_NAMEs: KWIATKOWSKI, DAVID J. (contact)

PROJECT_TERMS: Adult;analog;anti-tumor agent;Antitumor Response;Atlases;Biochemical Pathway;Cell Culture Techniques;Cell model;Cells;Clinical;Cytostatics;Data;Development;Drosophila genus;Elements;Event;experimental study;fly;FRAP1 gene;Genetic;Genetic Transcription;Goals;Growth;Growth Factor;Hamartoma;Heart;Human;improved;in vivo;Inherited;inhibitor;Insulin;Intestines;Kidney;lipidomics;Malignant Neoplasms;Mammalian Cell;Melanoma;Metabolic;Metabolism;metabolomics;Modeling;Molecular;mTOR Inhibitor;Mus;Nature;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;nucleotide metabolism;Nutrient;Pathogenesis;pharmacologic;phosphoproteomics;Physiological;programs;Proliferating;Property;Protein Kinase;Proteomics;PTEN gene;Pyrimidine;Research;Resistance;response;Role;Signal Transduction;Sirolimus;stem cells;Substrate Specificity;success;Syndrome;synergism;Testing;Therapeutic;Tissue Model;Tissues;transcription factor;TSC2 gene;Tuberous Sclerosis;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Suppressor Proteins;Validation

PROJECT_TITLE: Project 1: Identifying  new therapeutic avenues to selectively target tumors with uncontrolled mTORC1 activation


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The treatment of Alzheimer's disease has been hampered by our limited understanding of how the molecular pathology affects the neural activity that underlies cognition. The research proposed in this application will assess how loss and dysfunction of a vulnerable type of neurons impairs how the hippocampus retrieves, encodes, and consolidates information. It will further test an intervention to stimulate these neurons in order to rescue memory, informing future treatments.

PI_NAMEs: AERY JONES, EMILY ASTER (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;aged;Alzheimer's Disease;Alzheimer's disease model;Area;Automobile Driving;Cause of Death;Chronic;Cognition;cost;Data;Electrophysiology (science);entorhinal cortex;Environment;evidence base;experimental study;Faculty;Fire - disasters;Functional disorder;Future;Goals;Hippocampus;human old age (65+);Impairment;implant design;in vivo;inhibitory neuron;Intervention;Learning;Maps;Measures;Medial;Memory;Memory impairment;Memory Loss;Mentors;Mentorship;molecular pathology;mouse model;Mus;Nerve Degeneration;neural;neuron loss;Neuronal Dysfunction;Neurons;novel;optogenetics;Parvalbumins;Pathway interactions;Pattern;Phase;Play;Population;Positioning Attribute;Qualifying;Research;Resources;Rest;Retrieval;Role;Somatostatin;spatial memory;statistics;Techniques;Testing;Training;translational neuroscience;Universities

PROJECT_TITLE: Dynamics of Hippocampal Inputs in Alzheimer's Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE The Partnership between Ponce Health Sciences University (PHSU) in Puerto Rico and the Moffitt Cancer Center (MCC) in Tampa is focused on reducing cancer disparities in the Hispanic/Latino (H/L) communities and contributing to the elimination of health disparities in the H/L population at large. The Partnership aims to provide the means to expand research capabilities of the ISUPS (PHSU) and enhance research on cancer health disparities at the NCI-designated Cancer Center (MCC). The joint programs have resulted in successful outcomes in cancer research, education, training, community outreach and in biobanking.

PI_NAMEs: DUTIL, JULIE ;MATTA, JAIME L;MONTEIRO, ALVARO N;WRIGHT, KENNETH LYNN (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Accreditation;Achievement;Address;Admixture;Advocate;Affect;anti-cancer research;Basic Cancer Research;Basic Science;Bay Region;biobank;Biological;Cancer Center;cancer clinical trial;cancer education;cancer health disparity;Cancer Patient;career;Caregivers;catalyst;Clinical;Clinical Research;Collaborations;Communication;Communities;Community Developments;community empowerment;community engagement;Community Health;Community Health Education;Community Outreach;Complex;Comprehensive Cancer Center;COVID-19 pandemic;Development;Direct Costs;disparity gap;Doctor of Philosophy;doctoral student;Earthquakes;Education;Educational Materials;Ensure;Environment;Evaluation;Evaluation Research;Evolution;experience;Faculty;Florida;forging;Fostering;Funding;Genetic;genomic data;Genomics;Goals;graduate medical education;Grant;Growth;Health;Health Disparities Research;health disparity;Health Educators;Health Sciences;Health Services Accessibility;Hematology;Hispanic;Hurricane;improved;Infrastructure;innovation;Institution;inter-institutional;Intervention;Joints;Language;Latino;Latino Population;Malignant Neoplasms;Medical;Medical Students;Minority Participation;Natural Disasters;NCI-Designated Cancer Center;novel;Oncology;Operative Surgical Procedures;Outcome;outreach;outreach program;Peer Review;Population;Postdoctoral Fellow;Poverty;Preparation;Process;Productivity;programs;Psychological Factors;Publications;Puerto Rico;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Support;Residencies;resilience;Resources;Science;social factors;social media;Specimen;Tissue Microarray;Training;translational cancer research;undergraduate student;Universities

PROJECT_TITLE: 2/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The Administrative Core will help assure that the program project is well-managed financially. This core will assure facilitate scientific review and ongoing administrative support and coordination of the program as a whole.

PROJECT_TERMS: Advisory Committees;Alpha Particle Emitter;Area;Awareness;Basic Science;clinical implementation;Clinical Research;clinically relevant;Collaborations;Communities;data exchange;dosimetry;experience;Exposure to;Faculty;Fostering;Funding;Goals;Group Meetings;Image;Industry;interest;Internships;Leadership;meetings;member;next generation;Occupational activity of managing finances;Outcome;Preparation;programs;Progress Reports;Radiobiology;Radiopharmaceuticals;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Schedule;Scientist;Services;student participation;Students;summer internship;summer student;Training;Translational Research;Universities;Work

PROJECT_TITLE: Administrative


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD);Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The studies outlined in this project will determine brain circuits that underlie sex differences in endogenous pain modulatory function, the role of testosterone in maintaining efficient pain modulatory circuits, and the mechanistic links between dysfunctional pain modulatory systems, chronic orofacial pain conditions, such as temporomandibular disorders (TMD), and TMD-related comorbid pain conditions. Testosterone plays a critical role in maintaining efficient endogenous pain modulatory function, and hormone therapy in both transgender and cisgender individuals is known to modulate pain processing. The basic knowledge gained from this project will aid in the development of novel evidence-based pain treatment strategies that are tailored uniquely for either women or men, and will provide valuable insights on pain management for both transgender and cisgender individuals undergoing hormone therapy.

PI_NAMEs: DA SILVA, JOYCE TEIXEIRA;RO, JIN Y (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Affect;Androgen Receptor;Animals;Anterior;Anti-androgen Therapy;antinociception;Attenuated;Behavioral Paradigm;Biological Assay;Brain;Brain region;Burning Mouth Syndrome;central pain;Chronic;chronic painful condition;cingulate cortex;cisgender;Clinical;clinical pain;Combined Modality Therapy;comorbidity;conditioned pain modulation;craniofacial;Data;Development;diffuse noxious inhibitory control;Disease;Disproportionately impacts women;evidence base;Evidence based treatment;Female;Functional disorder;Functional Magnetic Resonance Imaging;Gender;gender difference;gender transition;Genetic;genetic manipulation;High Prevalence;hormone therapy;Human;Hypersensitivity;improved;Incidence;indexing;Individual;insight;Irritable Bowel Syndrome;Knowledge;Link;male;Measures;Mediating;men;midbrain central gray substance;Migraine;Modeling;neural circuit;Neurobiology;Neurons;novel;Orchiectomy;Orofacial Pain;Outcome;Pain;Pain Disorder;pain inhibition;Pain management;Pain Measurement;pain outcome;pain processing;pharmacologic;Play;pre-clinical;Pre-Clinical Model;Prevalence;Property;Psychophysics;Rattus;response;Rest;Risk;Risk Factors;Role;scale up;Severities;sex;Sex Differences;System;Temporomandibular Joint Disorders;Testing;Testosterone;Therapeutic;TMD treatment;transgender;treatment response;treatment strategy;Visceral;Woman;women versus men;women's treatment;Work

PROJECT_TITLE: The Role of Testosterone on Mediating Sex and Gender Influences on Chronic Orofacial Pain Conditions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(52)R]


NIH_SPENDING_CATS: Cancer;Genetics;Nutrition

PHR: Project 2: Narrative Over the past ten years it has become clear that many tumors rewire their metabolism to support rapid growth, but that the molecular details of how each tumor rewires its metabolism depends on the unique oncogenes and tumor suppressors that dominantly control metabolism, which include all of the hamartoma syndrome genes, as the PI3K/ mTOR/ LKB1 pathways play a major role in metabolic control in normal and cancer cells. The focus of this project is to better understand metabolic vulnerabilities and to more comprehensively define therapeutic metabolic targets that would support the development of biomarker driven clinical trials to evaluate such drugs in patients with germline or the many tumors containing sporadic mutations in hamartoma syndrome genes (PTEN, LKB1, TSC1, TSC2).

PROJECT_TERMS: Alanine;Algorithms;Back;Binding;Biochemical;Biological;biomarker development;biomarker driven;Biophysics;cancer cell;cell growth;Cell Line;Cells;Cellular Metabolic Process;Clinical Trials;Collaborations;Computer software;CRISPR/Cas technology;Data;Dietary Intervention;Disease;Drosophila genus;drug development;Drug usage;Engineering;Enzymes;Event;Family;fly;Folliculin;FRAP1 gene;Funding;gene network;Genes;Genetic;Genetic Crosses;Germ Lines;Germ-Line Mutation;glucose metabolism;Glycerol;Growth;Hamartoma;Human;Human Cell Line;Impairment;Knock-in;Knock-out;lipid metabolism;loss of function mutation;Lung Neoplasms;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolism;metabolomics;Methods;Molecular;mosaic variant;mTOR Signaling Pathway;Mus;mutant;Mutation;new technology;new therapeutic target;Normal Cell;novel;novel therapeutics;Nuclear Translocation;Nutrient;Oncogenes;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CG gene;Play;pre-clinical;Protein Kinase;Proteins;Proteomics;PTEN gene;rapid growth;Regulation;Research;response;Role;Sampling;Serine;Signal Transduction;Site;STK11 gene;Substrate Interaction;Substrate Specificity;Syndrome;TFE3 gene;Therapeutic;Tissues;transcription factor;Triose-Phosphate Isomerase;TSC1 gene;TSC2 gene;tumor;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Project 2: Identifying Metabolic vulnerabilities and targets in cancers with mutations in hamartoma genes


PHR: Project Narrative The Animal Models, Pathology and Tissue Core B will collect, process and provide centralized gross and histopathologic and in situ biomarker analysis for all biospecimens in the 4 Program Projects. These projects all rely on core B for expertise and methodologies to test hypotheses on optimization of αRPT dose adjustments, without causing toxicity, a current unmet need in αRPT cancer therapeutics and public health. To address this unmet need, in experiments outlined in the application, facilitated by Core B, dosimetry-driven treatment planning, in combination with a radiobiologic understanding of how absorbed dose translates to biologic effect, will reduce the scope of human experimentation (costs and timeline) needed to clinically optimize αRPT for cancer patients.

PI_NAMEs: GABRIELSON, KATHLEEN LOUISE (contact)

PROJECT_TERMS: absorption;Address;Alpha Particle Emitter;Alpha Particles;Anatomy;Animal Experiments;Animal Model;animal tissue;Animals;Area;Autopsy;Biodistribution;Biological;Biological Assay;Biological Markers;Cancer Patient;cancer therapy;Cell Line;Clinical;Clinical Trials;Collaborations;Collection;Communities;Consultations;cost;Data;Data Analyses;data management;Data Storage and Retrieval;design;digital imaging;Disseminated Malignant Neoplasm;DNA Damage;DNA Repair;DNA Repair Pathway;Dose;dosimetry;Drug Kinetics;experience;Experimental Designs;experimental study;Goals;Guidelines;Healthcare;Histopathology;Human;Human Experimentation;human tissue;Image;improved;In Situ;inhibitor;Institution;Knock-out;Knowledge;Malignant Neoplasms;Measurement;member;Methodology;Modality;model design;Molecular;Monitor;Neoplasm Metastasis;non-invasive imaging;Normal tissue morphology;Organ;Pathologic;Pathologist;Pathology;Patient Care;Patients;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;Phase I Clinical Trials;Photons;Predisposition;Procedures;Process;programs;prospective;Protocols documentation;Public Health;Radiation;Radiobiology;Radioisotopes;Radiopharmaceuticals;Reproducibility;Research;Research Personnel;resistance mechanism;Resources;Retrieval;Role;sample collection;Services;sex as a biological variable;side effect;single photon emission computed tomography;Specimen;success;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic procedure;Therapeutic Research;timeline;Tissue Sample;Tissues;Toxic effect;Translating;treatment planning;Tumor Tissue;Universities;Work

PROJECT_TITLE: Core 1: Animal Models, Pathology and Tissue


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Although human papillomavirus-based detection followed by same-day, onsite treatment, an approach called HPV-based screen-and-treat (SAT), has been included in global and national guidelines, the approach has not yet been widely implemented outside research settings. We hypothesize that an HPV-based, point-of-care, screen-and-treat (POC-SAT) implementation strategy will increase the proportion of women who are screened and treated, will be complementary to centralized HPV testing, and will be affordable.

PI_NAMEs: ARENDSE, JUANITA OLIVIA;CASTOR, DELIVETTE  (contact);MBATANI, NOMONDE HAZEL;SAIDU, RAKIYA SAIDU;SHELTON, RACHEL C;TEHRANIFAR, PARISA

PROGRAM_OFFICER_NAME: HANISCH, RACHEL ANN

PROJECT_TERMS: Acceleration;aged;Cancer Control;Cancer Etiology;Cervical;Cervical Cancer Screening;Clinical;clinical care;Clinical Trials;Collaborations;Communities;Complement;cost;Cost Savings;Cytology;Detection;Development;Education;Effectiveness;Eligibility Determination;Equity;evidence base;Evidence based intervention;Fostering;girls;global health;Goals;Guidelines;healing;Health;health care settings;health inequalities;Health Sciences;Healthcare;HPV screening;Human Papillomavirus;implementation barriers;implementation evaluation;implementation framework;implementation research;implementation science;implementation strategy;innovation;Intervention;Knowledge;knowledgebase;Lead;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Medical center;Mentorship;Mission;Outcome;point of care;poor communities;Population Control;premalignant;Prevention strategy;primary care setting;Primary Prevention;Province;Public Health;Public Sector;Recommendation;Research;Research Methodology;Research Personnel;Resource-limited setting;Safety;scale up;screening;screening program;Secondary Prevention;Seminal;Site;South Africa;Testing;Training;treatment duration;treatment site;Universities;uptake;Vaccinated;Vaccination;Woman;Women's Health;Women's mortality;women's treatment;Work;World Health Organization

PROJECT_TITLE: The Empilisweni Center for Women's Health - Advancing Implementation of Equitable Cervical Cancer Control


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal aims to develop fully autonomous self-driving laboratories that quickly and efficiently engineer proteins without human intervention, feedback, or bias. Engineered proteins have broad biomedical applications including as antibody and enzyme therapeutics, biocatalysts to synthesize pharmaceutical compounds, molecular imaging agents, and sensitive molecular diagnostics.

PI_NAMEs: ROMERO, PHILIP ANTHONY (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Amino Acid Sequence;Antibodies;Artificial Intelligence;artificial intelligence algorithm;automated algorithm;Automation;Automobile Driving;Biochemical;Biological Response Modifier Therapy;Biotechnology;cell behavior;Cells;chemical reaction;Chemicals;Chemistry;Complex;Computer Models;Computer software;Consumption;Data;data modalities;data sharing;Decision Making;deep learning;design;Directed Molecular Evolution;Disease;Disparate;DNA biosynthesis;Engineering;Environment;enzyme activity;Enzymes;Evolution;experimental study;Feedback;fitness;Food;Genes;Growth;high dimensionality;high throughput screening;Human;imaging agent;improved;intelligent agent;Intervention;Laboratories;large datasets;Learning;Measurement;Medicine;Metadata;Methodology;Modeling;molecular diagnostics;molecular imaging;Mutation;Nature;Neighborhoods;open source;Peptide Hydrolases;Peptide Signal Sequences;Pharmacologic Substance;Polymers;Process;Protein Biosynthesis;Protein Engineering;Proteins;Reproducibility;Research Personnel;robotic system;Signal Pathway;small molecule;Source;Structure;success;synthetic biology;System;Testing;Therapeutic;therapeutic enzyme;Time;Uncertainty;Variant;Walking

PROJECT_TITLE: Self-driving laboratories for autonomous exploration of protein sequence space

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Networking and Information Technology R&D (NITRD);Radiation Oncology

PHR: Project Narrative The Biostatistics Core (Core C) serves as a centralized resource to all P01 investigators and promotes synergy across projects and resources. It enhances the abilities of projects to address key scientific questions that will lead to wide implementation of αRPT dosimetry and thereby improve survival for currently incurable cancers . The work of Core C is to provide informatics support and ensure that clinical and laboratory studies are carried out using sound designs and appropriate analysis methods in order to reach justifiable scientific conclusions.

PI_NAMEs: WANG, HAO  (contact)

PROJECT_TERMS: absorption;Address;Adherence;Adoption;Adverse event;Alpha Particle Emitter;Alpha Particles;Animal Model;Bioinformatics;Biological;Biological Markers;biomarker identification;Biometry;Biostatistics Core;Cancer Center Support Grant;Clinical Research;Collaborations;Communication Methods;complex data;Consultations;Data;data acquisition;Data Analyses;Data Collection;data dissemination;Data Element;data exchange;data infrastructure;data integration;Data Linkages;data management;data quality;Data Storage and Retrieval;Database Management Systems;Databases;Dedications;design;Development;Dose;dosimetry;Ensure;Evaluation;Faculty;flexibility;Formulation;Goals;Human Resources;human subject;Image;improved;in vivo evaluation;Informatics;informatics infrastructure;Infrastructure;innovation;Laboratory Study;Link;Malignant Neoplasms;Manuscripts;medical schools;meetings;member;Methodology;Methods;Modeling;Monitor;novel;Oncology;Pathology;Patient-Focused Outcomes;Patients;Positioning Attribute;preclinical study;Preparation;Procedures;Process;Program Research Project Grants;programs;Protocols documentation;Publications;Quality Control;quantitative imaging;Radiobiology;Radiopharmaceuticals;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Running;Sample Size;Sampling;Science;Secure;Service Statistics;sound;Specialist;Specific qualifier value;Specimen;Statistical Models;stem;synergism;Techniques;Tissue Banks;Tissues;tool;Translational Research;translational study;treatment planning;treatment response;Universities;Work

PROJECT_TITLE: Core 2: Biostatistics


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis;Urologic Diseases

PHR: Project 3: Narrative In this project, we will examine the JUN-AXL pathway in TSC2/TSC1 deficient tumors, clarify how MITF/TFE transcription factors are regulated in TSC null cells and tumors, and study how renal organoids derived from TSC2 null induced pleuripotent stem cells (iPSC) are dependent on transcription factors. This research has relevance for all of the tumors that occur in TSC, including renal angiomyolipomas and lymphangioleiomyomatosis. In addition, this research has potential value for any cancer with TSC gene loss, which is about 2% of all adult cancers.

PROJECT_TERMS: Ablation;Adult;Anabolism;Angiomyolipoma;Apoptotic;Brain;cancer cell;Cell Death;Cell Death Induction;Cell Line;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Data;data sharing;Dependence;Development;Drosophila genus;Epigenetic Process;Event;Family member;Frequencies;Gene Expression;Genes;Genetic Transcription;Genotype;Glutathione;Growth;Hamartoma;Health;Heart;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;inhibitor;JUN gene;jun Oncogene;Kidney;Kidney Neoplasms;kinase inhibitor;Knock-out;Libraries;Lung;Lymphangioleiomyomatosis;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammalian Cell;metabolomics;Methods;Modeling;Molecular;multiple omics;Mus;Mutate;Mutation;Neoplasm with Perivascular Epithelioid Cell Differentiation;novel;Nuclear;Null Lymphocytes;Organoids;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;programs;Proteins;Publishing;Renal Angiomyolipoma;Renal Cell Carcinoma;Research;Research Personnel;Resolution;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Sirolimus;Specificity;Syndrome;System;TFE3 gene;Therapeutic;transcription factor;transcriptome sequencing;Translating;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor;Tumor Cell Line;tumor growth;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 3:  Identifying transcriptional driver genes and targeting transcription in TSC


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: ANESTHESIOLOGY

PHR: Individuals with autism spectrum disorder (ASD) are more likely to die prematurely and may have considerably shorter life expectancy than the general population. The proposed project aims to assess the mortality risk and causes of death in about one million Medicaid beneficiaries with ASD compared with four million Medicaid beneficiaries without ASD. Findings from this project will help advance our understanding of the natural history and long-term prognosis of ASD and facilitate the development of effective strategies and interventions to reduce excess mortality associated with ASD.

PI_NAMEs: LI, GUOHUA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 8 year old;Accidental Injury;Adolescent and Young Adult;adolescent with autism spectrum disorder;Adult;Age;Age Specific Death Rate;aged;autism spectrum disorder;autistic children;Behavior Therapy;beneficiary;Biology;California;Cause of Death;Cessation of life;Characteristics;Child;Child Health;Client;Clinical;cohort;comorbidity;Complex;cost;Data;Data Files;Death Rate;design;Development;Developmental Disabilities;Diagnosis;disability;Drowning;effective intervention;Eligibility Determination;Enrollment;Epidemiology;epidemiology study;Epilepsy;ethnic disparity;Excess Mortality;Funding;Gender;General Population;Health;health care service;Health Insurance;Health Policy;Health Services;Hispanic;Housing;improved;Income;indexing;Individual;individuals with autism spectrum disorder;Information Systems;Intellectual functioning disability;Intervention;Life Cycle Stages;Life Expectancy;life span;Literature;longitudinal analysis;Low income;Massachusetts;Medicaid;Medicaid eligibility;mental health counseling;Monitor;mortality;mortality disparity;mortality risk;Natural History;Neurodevelopmental Disability;Occupational Therapy;Pneumonia;Population;Population Study;premature;Prevalence;Prognosis;programs;public health insurance;Qualifying;racial disparity;Reporting;Research;Risk;Risk Factors;Sample Size;screening;Services;sex;Social Work;Special needs;Suicide;Surveillance Program;Sweden;Time;transition to adulthood;Transportation;United States;Utah;Vocational Education;waiver;Wisconsin;young adult

PROJECT_TITLE: Mortality in Autism

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

PHR: Project Narrative The Patient Data Core will provide oversight of patient data collection and use required to complete the scientific objectives of the program project, assuring that Investigators have access to the required data with adherence to all standards of privacy and ethics. This core will also work towards increasing collaboration and data sharing among academic and industry researchers in the field of radiopharmaceuticals, as well as encouraging data collection as part of standard of care radiopharmaceutical therapy, to strengthen future scientific inquiry in this exciting and growing field.

PI_NAMEs: KIESS, ANA PONCE (contact)

PROJECT_TERMS: absorption;Adherence;Adoption;Agreement;Alpha Particle Emitter;Clinical Data;Clinical Research;Collaborations;Data;data acquisition;Data Collection;data sharing;Databases;Dose;dosimetry;Drug Kinetics;ERBB2 gene;Ethics;flexibility;FOLH1 gene;Future;Goals;Image;Industry;J591 Monoclonal Antibody;Patient imaging;Patients;Positron-Emission Tomography;Privacy;programs;Protocols documentation;Radiobiology;Radiopharmaceuticals;Research;Research Personnel;response;Scientific Inquiry;single photon emission computed tomography;standard of care;Standardization;Toxic effect;treatment optimization;tumor;Work

PROJECT_TITLE: Core 3: Patient Data


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative We propose to dissect the cellular and molecular response of IDH-mutant gliomas to mutant IDH inhibitors (IDHi), and characterize the mechanisms underlying resistance. This proposal is relevant to the public health and NCI mission because IDH mutant gliomas are a leading cause of cancer-death and morbidity in adults younger than age 45. We will profile clinical samples on IDHi by single-cell multi- omics, perform advanced computational analyses and leverage novel pre-clinical models to test genetic and microenvironmental regulators of tumor response to IDHi.

PI_NAMEs: CAHILL, DANIEL P.;SUVA, MARIO LUCA (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 19q;Active Sites;Affect;Age;Arginine;Astrocytoma;ATRX gene;Biological Assay;cancer cell;Cancer Etiology;Cell Cycle;Cell Survival;Cells;Cessation of life;Chromatin Structure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;cohort;Computer Analysis;Cues;Data;Development;Differentiation Therapy;Diffuse;Disease;DNA Sequence Alteration;Epigenetic Process;experimental study;Gene Expression;Gene Mutation;Genes;Genetic;genetic testing;Glioma;Growth;Heterozygote;Histidine;Human;In Vitro;in vitro Assay;in vivo;Indolent;Infiltrative Growth;inhibitor;Isocitrate Dehydrogenase;knock-down;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolism;Mission;Modeling;Molecular;Morbidity - disease rate;mouse model;multiple omics;Mus;mutant;Mutation;neoplastic;nerve stem cell;Normal Cell;notch protein;novel;Nuclear Pore Complex;oligodendroglioma;Oncogenic;Organoids;patient subsets;Patients;Persons;PIK3CA gene;Population;Pre-Clinical Model;Process;Production;programs;promoter;prototype;Public Health;Research Proposals;Resistance;resistance gene;response;Sampling;single cell genomics;single-cell RNA sequencing;Specimen;stem cells;stem-like cell;Supporting Cell;Testing;Tetracyclines;therapeutic target;TP53 gene;tumor;tumor growth;tumorigenesis;young adult

PROJECT_TITLE: Dissecting the Determinants of IDH-mutant Gliomas Response to Mutant IDH Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MCTC-S(01)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: WRIGHT, KENNETH LYNN (contact)

PROJECT_TERMS: Advisory Committees;Affect;anti-cancer research;Area;Brassicaceae;Budgets;Cancer Center;cancer health disparity;career;career development;Career Mobility;Categories;Collaborations;Committee Members;Communication;Communities;Community Health;conflict resolution;COVID-19 pandemic;Development;Doctor of Philosophy;driving force;Earthquakes;education research;Ensure;expectation;experience;Faculty;Fostering;Funding;Funding Agency;Future;Goals;Grant;Growth;Guidelines;Health Disparities Research;Health Educators;Health Sciences;Hispanic;Hurricane;Incubators;Infrastructure;innovation;Institution;Knowledge;Latino;Leadership;member;Mentors;minority engagement;minority health;pandemic disease;Persons;Preparation;Productivity;programs;Progress Reports;Publications;Puerto Rico;recruit;Recruitment Activity;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Resource Development;Resource Sharing;Resources;Scientist;Source;success;Supervision;Training Activity;Underrepresented Minority;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer

PHR: Core A: Narrative The overall goal of this program project application is to find treatments for the hamartoma syndromes, and the common cancers in which these same genes (TSC1, TSC2, LKB1, PTEN) are involved. This administrative core serves a critical function in the administration and facilitation of this overall research program.

PROJECT_TERMS: Accounting;Administrator;Area;Boston;Budgets;Collaborations;Core Facility;Counseling;Effectiveness;Electronic Mail;Facilities and Administrative Costs;Funding;Genes;Goals;Hamartoma;Human Resources;Individual;Institution;Laboratories;Location;Malignant Neoplasms;Medical;meetings;member;Molecular;Monitor;Pathogenesis;Preparation;Productivity;programs;Progress Reports;PTEN gene;Reporting;Research;Research Personnel;STK11 gene;symposium;Syndrome;System;TSC1 gene;TSC2 gene;Visit;Work

PROJECT_TITLE: Core A: Administration


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cancer;Genetics;Precision Medicine;Rare Diseases;Tuberous Sclerosis

PHR: Core B: Narrative The mass spectrometry core will provide proteomics/phosphoproteomics, metabolomics and lipidomics services for the three major projects from cancer cells, tumor tissue and biological fluids using tandem mass spectrometry (LC-MS/MS). These services will support the discovery of novel pathways and drug targets for Hamartoma syndromes and related cancers stemming from defects in the tuberous sclerosis complex (TCS1-TSC2) genes.

PROJECT_TERMS: Acetylation;Apoptotic;Biological;Blood capillaries;Body Fluids;cancer cell;Cell Death;Cell Line;Cell model;Cells;Computer software;Defect;Development;Dose;Drosophila genus;Drug Targeting;Elements;Event;experimental study;fly;FRAP1 gene;gain of function;Genes;genetic manipulation;Glucose;Glutamine;Hamartoma;Human;Human Cell Line;human induced pluripotent stem cells;Hybrids;Immunoprecipitation;improved;in vitro Model;in vivo;inhibitor;instrument;instrumentation;Ions;Isotopes;Joints;jun Oncogene;Kidney;Label;lipidomics;Lipids;Liquid substance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;Monitor;mouse model;mTOR Inhibitor;multiple omics;multiple reaction monitoring;Mus;mutant;Mutation;Nonesterified Fatty Acids;novel;novel therapeutics;Pathogenesis;Pathway interactions;Peptides;Pharmacotherapy;Phase;Phospholipids;phosphoproteomics;Phosphorylation;Phosphorylation Site;Post Translational Modification Analysis;Post-Translational Modification Site;Post-Translational Protein Processing;potential biomarker;Preparation;programs;protein complex;Protein Kinase;Proteins;Proteomics;PTEN gene;Publications;Pyrimidine;Reaction;Regulation;Resolution;Resources;response;Role;Running;Sampling;scaffold;Services;Signal Transduction;Sirolimus;Source;Stable Isotope Labeling;stem;Stimulus;STK11 gene;success;Syndrome;tandem mass spectrometry;targeted biomarker;targeted treatment;Technology;TERT gene;Tissues;transcription factor;Triglycerides;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor;tumor growth;Tumor Tissue;Ubiquitination;Xenograft procedure

PROJECT_TITLE: Core B: Mass Spectrometry, proteomics, metabolmics and lipidomics


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PI_NAMEs: CASTOR, DELIVETTE  (contact)

PROJECT_TERMS: Acceleration;access disparities;Address;Affect;aged;Black race;burden of illness;Cancer Control;Cancer Etiology;cancer health disparity;Cervical;Cervical Cancer Screening;Cessation of life;Clinical;clinical care;Clinical Trials;Collaborations;Communities;community engagement;Coordination and Collaboration;Country;Decision Making;Disease;Eligibility Determination;Ensure;Equity;evidence base;Evidence based intervention;experience;Food;Fostering;Generations;girls;global health;Goals;Government;Guidelines;healing;Health;health disparity;health inequalities;Health Services;Healthcare;HIV/TB;Home;Human Papillomavirus;implementation research;implementation study;Incidence;Inequity;infection rate;Infrastructure;Iron;Knowledge;Lead;Leadership;low and middle-income countries;Malignant neoplasm of cervix uteri;Mission;mortality;Performance;peri-urban;Persons;point of care;Prevention strategy;Primary Prevention;Productivity;programs;Province;Public Health;Recommendation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resource-limited setting;Resources;response;Rest;Safety;scale up;Scientific Advances and Accomplishments;screening;screening program;Secondary Prevention;Seminal;Shapes;Site;social;South Africa;success;synergism;Testing;treatment duration;Unemployment;Universities;uptake;Vaccinated;Woman;Women's Health;women's treatment;Wood material;World Health Organization

PROJECT_TITLE: Administrative and Engagement Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: CRESS, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Awareness;biobank;Blood;Breast;Breast Cancer Genetics;breast cancer genomics;Cancer Center;cancer diagnosis;cancer health disparity;cancer therapy;cancer type;Caribbean region;Clinical;Clinical Data;Clinical Trials;Collaborations;Colon;Colorectal Cancer;Communities;Community Health;Community Health Education;Community Outreach;Consent;Data;data registry;Data Set;Databases;Dedications;Demographic Survey;Development;DNA;Education;Education and Outreach;education research;exome sequencing;Funding;Future;Genetic;Genome;Germ Lines;Grant;Gynecologist;Health Disparities Research;health disparity;Health Educators;Health Sciences;Historical Survey;Hospitals;improved;Individual;innovation;International;Island;Latin America;Latin American;Latino;Logistics;Lung;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority Participation;Molecular;molecular phenotype;Molecular Profiling;neoplasm registry;novel;Oncologist;Organoids;outreach;Ovarian;patient derived xenograft model;Patient Education;Patient Recruitments;Patient Selection;Patients;Physicians;Physicians' Offices;Play;Population;precision medicine;Prevalence;Principal Investigator;Process;Prostate;Publications;Puerto Rican;Puerto Rico;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;RNA;Role;Science;Services;Specimen;Surgeon;System;targeted treatment;Techniques;Tissue Donations;Tissue Microarray;Tissues;Training;transcriptome sequencing;Translation Initiation;translational cancer research;Underrepresented Minority;Universities;Urologist

PROJECT_TITLE: Shared Resource Core: Puerto Rico BioBank


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Tobacco use is the leading cause of preventable death and disease in the US and is linked to nearly 20 different cancers . Although overall rates of tobaccouse have declined, the rate of decline has been much lower among marginalized groups who may experience greater exposure to certain social and contextual stressors (e.g., discrimination) that may impede health behavior change. This research will use a novel methodological and conceptual approach called intersectionality and cutting-edge mobile health technology (i.e., ecological momentary assessment and AutoSense) to examine how multiple aspects of sociodemographic identity, context, and interpersonal experiences interact to shape health inequities, which will improve the identification of specific populations at disproportionate risk for tobacco and cancer inequities and can inform the development of targeted cancer prevention interventions.

PI_NAMEs: POTTER, LINDSEY  (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: adaptive intervention;Address;Affect;anti-cancer research;Behavior;behavior change;Behavioral;Behavioral Mechanisms;Cancer Prevention Intervention;cancer risk;Cognition;comparative efficacy;Complex;contextual factors;Data;design;Development;Discrimination;Disease;Ecological momentary assessment;Emotions;ethnic minority;Ethnic Origin;experience;Exposure to;Female;Gender;Goals;Health;Health behavior;Health behavior change;health inequalities;Health Technology;Heterogeneity;improved;Individual;Inequity;innovation;insight;intersectionality;Intervention;Knowledge;lens;Link;Lived experience;Longitudinal Studies;Low income;low socioeconomic status;Malignant Neoplasms;marginalization;marginalized population;Mediating;Mentors;Methodology;Methods;mHealth;mHealth methodology;Minority Women;Mission;Modeling;Motivation;negative affect;novel;Persons;Phase;Population;Population Intervention;preventable death;preventive intervention;Process;psychosocial;Race;racial minority;Research;Research Design;Risk;Scientific Advances and Accomplishments;Self Efficacy;Shapes;Smoker;Smoking;social;Social Environment;social factors;sociodemographics;Socioeconomic Status;statistics;Stress;stressor;Technology;theories;Time;Tobacco;Tobacco Dependence;Tobacco use;Tobacco Use Cessation;Training;trend;Work

PROJECT_TITLE: Using mHealth to investigate intersectionality and health behaviors: Implications for conceptual models and cancer prevention interventions for marginalized populations

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: NARRATIVE – Overall Metastasis of tumor cells from the primary to distant sites is the primary cause of cancer -related death. We aim to identify mechanisms of metastasis in which tumor cells instruct immune cells and other stromal cells to tolerant them by focusing on the understudied role of lymph node invasion in tumor-mediated immunosuppression. Our findings promise to provide critical insights into blocking metastatic progression and thereby preventing cancer-related deaths.

PI_NAMEs: ENGLEMAN, EDGAR G. ;PLEVRITIS, SYLVIA KATINA (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adaptive Immune System;Address;Advanced Development;Affect;analytical tool;Anatomy;anti-cancer research;Archives;Area;Binding;biocomputing;Biological;biomarker identification;cancer cell;Cancer Etiology;Cancer Patient;cell type;Cells;Cessation of life;Clinical;cohort;Collaborations;Communities;community engagement;Complex;Computer Analysis;Computing Methodologies;Data;data integration;data management;Data Set;Dedications;Development;Disease;Distant;Distant Metastasis;draining lymph node;Ensure;Event;Funding;Generations;Genomics;Goals;Head and Neck Cancer;high dimensionality;Homeostasis;Human;Image;Imaging technology;Immune;immune clearance;Immune system;Immune Tolerance;Immunology;Immunosuppression;In Situ;in situ imaging;insight;interdisciplinary approach;Invaded;Kinetics;Knowledge;Lung Adenocarcinoma;lymph nodes;lymphatic drainage;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;member;Metastatic Neoplasm to Lymph Nodes;Methodology;Methods;migration;mouse model;multidisciplinary;multimodality;multiscale data;Mus;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Outcome;outreach;Patients;Pilot Projects;Population;pre-clinical;Predisposition;prevent;Primary Neoplasm;Process;Proteomics;Records;recruit;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Sampling;Series;single cell technology;single-cell RNA sequencing;Site;Solid;Solid Neoplasm;spatiotemporal;Stromal Cells;Stromal Neoplasm;System;Systems Biology;Technology;technology platform;Therapeutic;Tissues;tool;transcriptomics;treatment planning;treatment response;tumor;Tumor Biology;Tumor Immunity;tumor progression

PROJECT_TITLE: Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention;Women's Health Research

PI_NAMEs: DENNY, LYNETTE  (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Cancer Control;Cancer Control Research;career development;Cervical Cancer Screening;Chronic Disease;Clinical Research;Collaborations;Community Health Aides;Competence;Country;Development;economic evaluation;Education;Equity;Evaluation;evidence base;Evidence based intervention;experience;Foundations;Goals;Health;Health system;Healthcare Systems;implementation framework;implementation research;implementation science;implementation strategy;Income;Inequity;Infrastructure;innovation;interest;Knowledge;Lead;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;Mentorship;Methodology;Methods;Modeling;Politics;Population;prevent;Process;Program Development;programs;Province;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Research Project Grants;Research Training;Resources;scale up;screening;social;South Africa;Testing;theories;tool;Trainers Training;Training;Universities;Women's Health;Work;World Health Organization

PROJECT_TITLE: Research Capacity Building Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: ESCHRICH, STEVEN ALLEN (contact)

PROJECT_TERMS: Address;Admixture;analytical tool;ancestry analysis;Area;Big Data;biobank;Bioinformatics;Biometry;Cancer Center;cancer health disparity;Cell Line;cohort;Collaborations;Communication;Consent;Data;Data Analyses;Data Collection;data integration;data management;Data Scientist;design;Development;Disparity;DNA;Education;education research;Ensure;Environment;Evaluation;experience;Future;Genetic;Genome;genomic data;Genomics;Grant;Health Disparities Research;Health Sciences;high dimensionality;Hispanic;Hispanic-serving Institution;Improve Access;improved;Informatics;Infrastructure;infrastructure development;innovation;Institution;Latino;Latino Population;Lead;Life Cycle Stages;member;Molecular;Molecular Profiling;novel;Oncology;online resource;Online Systems;Participant;Phase;Physicians;precision medicine;Proteomics;Puerto Rico;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Sample Size;Sampling;Science;Services;skills;software infrastructure;statistics;Students;synergism;System;The Cancer Genome Atlas;Tissues;tool;Training;transcriptome sequencing;Translations;Universities;Vision;Visualization software

PROJECT_TITLE: Shared Resource Core: Quantitative Sciences Core


NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The human nucleotide excision repair (NER) pathway processes damage to DNA caused by radiation and various environmental and endogenous toxins, but also contributes to resistance to chemotherapies that damage DNA. This research will test the hypothesis that defects in NER sensitize cancer cells to DNA damaging drugs such as platinum agents by investigating the effect of mutations in, and developing inhibitors of, the critical scaffolding NER protein XPA. These studies will provide important new insights into the etiology of cancer therapy resistance and lay the foundation to explore the potential of inhibiting NER as a means to enhance anticancer therapies and contribute to the implementation of precision medicine in treating cancers.

PI_NAMEs: CHAZIN, WALTER J. (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Affect;Affinity;anti-cancer treatment;anti-tumor drug;Binding;Binding Sites;Biological Assay;cancer cell;Cancer cell line;Cancer Etiology;cancer genome;cancer therapy;cancer type;Cells;chemotherapy;Cisplatin;Clinic;combinatorial;Data;Defect;design;Development;DNA;DNA Damage;DNA Repair;drug sensitivity;ERCC1 gene;ERCC2 gene;Evaluation;Foundations;Functional disorder;gene repair;Generations;genome database;Genomics;Goals;Human;improved;inhibitor;insight;Knowledge;Lead;Libraries;Link;Location;loss of function mutation;Malignant Neoplasms;Missense Mutation;Modeling;Molecular;mutant;Mutate;Mutation;neoplastic cell;Nucleotide Excision Repair;Nucleotide Excision Repair Inhibition;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Platinum;Platinum Compounds;precision medicine;Process;Proteins;Publications;Radiation;repaired;replication factor A;Reporter;Research;Resistance;scaffold;Scaffolding Protein;small molecule inhibitor;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;tool;tool development;Toxin;translational potential;tumor;Work;X-Ray Crystallography;Xenograft Model;Xeroderma Pigmentosum Complementation Group A

PROJECT_TITLE: The XPA scaffold protein in Nucleotide Excision Repair

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative This K99/R00 Pathway to Independence Award seeks to provide training in the design and management of longitudinal pregnancy cohort studies, advanced biostatistics, and the measurement and interpretation of extracellular vesicles, steroid hormones, and infant and toddler neurodevelopmental outcomes under a Developmental Origins of Health and Disease (DOHaD) framework to support the applicant's transition to research independence. Through the training plan, the applicant will develop the skills and expertise necessary to establish a translational research program that will examine a network of perinatal pathways through which maternal, fetal, and placental physiology impacts child neurodevelopmental outcomes, including risk for ASD. This approach may reveal new biological mechanisms underlying neurodevelopmental risk and may provide early-emerging biological markers, which are critical for identifying children in need of early intervention.

PI_NAMEs: FIRESTEIN, MORGAN  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Address;Age Months;Amniotic Fluid;Androstenedione;autism spectrum disorder;Award;Basic Science;Biological;Biological Markers;Biometry;Brain;career;Cells;Child;Clinical Psychology;Clinical Research;cohort;Cohort Studies;Communication;Data;design;Development;Diagnosis;Disease;Early identification;Early Intervention;Emotional;Endocrinology;Enzyme-Linked Immunosorbent Assay;epidemiology study;extracellular vesicles;fetal;fetal blood;Functional disorder;Gene Expression Regulation;Gestational Diabetes;Goals;Health;Hydroxyprogesterone;Hypertension;Individual;Infant;Interdisciplinary Study;Lead;Lifestyle-related condition;longitudinal dataset;Longitudinal Studies;Mammalian Cell;Mass Spectrum Analysis;Measurement;Measures;Mediating;Mediation;Metabolic;MicroRNAs;Molecular Biology;Motor;motor deficit;neurobehavioral;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neuropsychiatry;offspring;Outcome;Parents;Pathway interactions;Perinatal;Physiology;Placenta;Plasma;postnatal;Pregnancy;pregnancy disorder;Pregnant Women;prenatal;Progesterone;programs;Proteins;Psychiatry;Quality of life;recruit;Reporting;Research;Research Design;Risk;Risk Factors;RNA;Role;service intervention;skills;social;Source;statistics;Steroid biosynthesis;steroid hormone;Steroids;Testosterone;Toddler;tool;Training;Transcriptional Regulation;Translational Research;translational research program;Up-Regulation;women's diagnosis

PROJECT_TITLE: Prenatal Extracellular Vesicles and Steroid Hormones as Biological Mechanisms Underlying Gestational Factors Associated with Neurodevelopmental Risk

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PI_NAMEs: PARK, JONG Y. (contact)

PROJECT_TERMS: Address;Admixture;Affect;Aftercare;androgen deprivation therapy;Androgen Receptor;Automobile Driving;biobank;Biological Markers;black men;Black Populations;Black race;Blood specimen;Cancer Center;cancer health disparity;cancer initiation;Cancer Patient;cancer type;Castration;Cell Line;Cells;Cessation of life;chemotherapy;clinical risk;clinically relevant;cohort;Data;data registry;Development;differential expression;disease phenotype;Disease Progression;Disparity;DNA Methylation;DNA Methylation Inhibition;docetaxel;Drug Modelings;Drug resistance;drug sensitivity;Drug usage;enzalutamide;Epigenetic Process;epigenetic variation;Failure;Florida;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene therapy;Genes;Goals;health care availability;Health Sciences;high risk;Hispanic;Hispanic Populations;improved;Incidence;Indolent;Latino;Latino Population;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methylation;methylation biomarker;methylation pattern;Molecular;Molecular Probes;mortality;neoplasm registry;Not Hispanic or Latino;novel;outcome disparities;patient oriented;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Play;Population;Populations at Risk;potential biomarker;Prediction of Response to Therapy;Prostate;prostate cancer cell line;Prostate Cancer therapy;Puerto Rican;racial disparity;racial population;Reporting;Research Project Grants;Resistance;response;Risk;risk stratification;Role;Sampling;Selection for Treatments;Series;Socioeconomic Status;targeted agent;taxane;The Cancer Genome Atlas;therapy resistant;Tissues;Treatment Failure;treatment response;tumor;Tumor Biology;tumor DNA;Universities;Validation;Work

PROJECT_TITLE: Project 1: Epigenetic variations associated with aggressiveness in prostate cancer among Puerto Rican men


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PI_NAMEs: SAIDU, RAKIYA SAIDU (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Adoption;Area;Biological Assay;Black race;Cancer Control;Cancer Etiology;care fragmentation;Cervical Cancer Screening;Cessation of life;Clinic;clinical care;Clinical Trials;Collaborations;Colposcopy;Consolidated Framework for Implementation Research;Cytology;Data;Death Rate;design;Development;Engineering;Epidemic;Equity;Evaluation;evidence base;Evidence based intervention;Feedback;follow-up;Geographic Locations;Guidelines;Health;Health care facility;health care settings;Health Personnel;Healthcare;Histologic;HIV;Human Papillomavirus;implementation barriers;implementation design;implementation efforts;implementation evaluation;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Inequity;informant;Infrastructure;International;Intervention;Interview;Knowledge;Laboratories;Learning;Lesion;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Medical Records;Methods;metropolitan;Mission;mortality;Outcome;Outcome Assessment;Output;Patients;point of care;point of care testing;Policies;poor communities;post implementation;Poverty;Primary Care;primary care setting;Primary Health Care;primary outcome;Process;Province;Public Health;Public Sector;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Research Project Grants;Resource-limited setting;Safety;scale up;screening;screening program;secondary outcome;Site;South Africa;South African;Structure;Surveys;synergism;System;Test Result;Testing;Triage;Universities;Visit;Woman;Women's Health

PROJECT_TITLE: Research Project 1


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Child maltreatment (CM) is a broad-ranging risk factor associated with compromised development and maladaptation, yet there is vast heterogeneity in the experience of CM and its developmental outcomes (i.e., risk heterogeneity). The proposed research is relevant to public health because it is expected to increase our understanding of risk heterogeneity in CM survivors (i.e., how variation in CM exposure influences variation in developmental course), which is necessary to improve the precision of our interventions. This project is relevant to NIH’s mission because a) findings can ultimately inform interventions with the potential to reduce the incidence of pathology and promote greater quality of life; and b) it will leverage $25 million of existing NIH investment in CM research to create a pooled data archive that can be used by the field to conduct more rigorous and reproducible science.

PI_NAMEs: RUSSOTTI, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Age;Big Data;biological systems;biopsychosocial;career development;Child;Child Abuse and Neglect;Child Development;Child Welfare;Chronic;cohort;Cohort Studies;Collaborations;cost;culturally appropriate intervention;Data;Data Analyses;data archive;data harmonization;Data Pooling;Data Set;data sharing;data sharing networks;design;Development;Developmental Course;Developmental Process;Dimensions;Economic Burden;Elements;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;experience;Exposure to;Funding;Goals;health disparity;Heterogeneity;high risk;improved;Incidence;Individual;innovation;Intervention;Investments;Knowledge;Learning;Life;Longitudinal cohort study;longitudinal design;Longitudinal Studies;meetings;Mentorship;Methodology;Methods;minority children;Mission;Modeling;multiple datasets;National Institute of Child Health and Human Development;Outcome;Pathology;Pathway interactions;Phenotype;Population;Process;prospective;psychologic;Public Health;Quality of life;Race;racial minority;Reproducibility;Reproducibility of Results;Research;Research Personnel;Research Training;resilience;Resources;Risk;Risk Factors;Sampling;Science;Severities;skill acquisition;skills;Source;Stretching;Subgroup;Survivors;System;Techniques;Testing;Time;Training;Training Programs;United States National Institutes of Health;Variant;Work;Youth

PROJECT_TITLE: Understanding Risk Heterogeneity Following Child Maltreatment: An Integrative Data Analysis Approach.


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Ovarian Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: PERES, LAUREN COLE (contact)

PROJECT_TERMS: adaptive immunity;ADRB2 gene;Adrenergic Receptor;Anxiety;Aspirin;Attenuated;biobank;biobehavior;Biological;Biological Assay;bisphosphonate;Black race;Cancer Biology;Cancer Center;cancer risk;cancer survival;carcinogenicity;Carcinoma;Case Series;Case/Control Studies;Chronic stress;Clinical;Data;Development;Diagnosis;Disease;Distress;Dose;education research;Emotional;Enzyme-Linked Immunosorbent Assay;epidemiologic data;Epithelial ovarian cancer;ethnic disparity;ethnic diversity;Ethnic Origin;Evaluation;exome;experience;Future;Gene Expression;Gene Expression Profile;Genes;Goals;Health Sciences;high risk;Hispanic;Hormones;Hospitals;Human;Immune;immune function;Immune response;Immunity;Immunosuppression;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Response;innovation;Intervention;Latina;Lead;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediating;Mental Depression;mouse model;Mus;Norepinephrine;Not Hispanic or Latino;novel;Outcome;outreach;ovarian cancer prevention;ovarian neoplasm;Pathway interactions;Patient Self-Report;Patients;pharmacologic;Pharmacotherapy;population based;Population Heterogeneity;Population Intervention;Population Study;prevent;Prevention strategy;Process;prospective;Prospective cohort;Prostaglandins;psychosocial;Puerto Rico;Race;racial disparity;racial diversity;Reporting;Research;Research Project Grants;Resources;response;restraint stress;Risk;Role;Sampling;Science;Serous;Services;Stress;Sympathetic Nervous System;systemic inflammatory response;Time;Tissues;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-associated macrophages;tumorigenesis;Universities;Up-Regulation;Woman;Work

PROJECT_TITLE: Project 2: The impact of biobehavioral factors and aspirin on ovarian cancer biology


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PI_NAMEs: MOODLEY, JENNIFER ROSE (contact)

PROJECT_TERMS: Acceleration;aged;Biological Assay;Budgets;Cancer Control;Cancer Etiology;cancer health disparity;Cervical;Cervical Cancer Screening;clinical care;Clinical Trials;Collaborations;cost;cost effective;cost effectiveness;cost estimate;Country;Cytology;Data;Data Collection;Decision Aid;Decision Making;design;Detection;detection assay;Development;DNA;economic evaluation;Economics;Effectiveness;Eligibility Determination;Equity;Evaluation;evidence base;girls;Goals;Guidelines;Health care facility;health economics;Health system;Healthcare;Heterogeneity;Human Papillomavirus;implementation evaluation;implementation science;implementation strategy;Incidence;incremental cost;Infrastructure;innovation;Intervention;Investments;Knowledge;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Maps;marginalized community;meetings;Methods;microcosting;Modeling;Molecular;mortality;Motion;new technology;Outcome;Patients;point of care;point of care testing;Policy Maker;post implementation;Prevention strategy;Primary Care;primary care setting;Primary Prevention;Process;Provider;Province;Public Health;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resource-limited setting;Review Literature;Safety;scale up;screening;screening guidelines;screening policy;screening program;Secondary Prevention;Seminal;Site;South Africa;synergism;System;Testing;theories;Time;Time and Motion Studies;tool;Translating;treatment duration;Universities;uptake;Vaccinated;Visual;Woman;Women's Health;Women's mortality;World Health Organization

PROJECT_TITLE: Research Project 2


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The healthcare system does not currently provide ways to identify and reduce healthcare safety threats, such as medication errors and device complications, that occur in the homes of children with complex medical conditions, especially for children from minority groups. This research will bring together experts, including diverse families, for a long-term, equity-focused collaborative Patient Safety Learning Lab that co-designs ways to identify, communicate, and prevent safety events that occur to children with complex medical conditions at home.

PI_NAMEs: FOSTER, CAROLYN C. (contact);WERNER, NICOLE E

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: The SafeCare@Home4Kids Learning Lab: Designing Safer Healthcare at Home for Children

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Chronic Pain;Clinical Research;Lung;Lung Cancer;Natural Products;Pain Research;Palliative Care;Therapeutic Cannabinoid Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Cannabis and cannabidiol (CAC) are estimated to be used by approximately 1 in 4 persons diagnosed with cancer, primarily to help manage common and problematic symptoms such as pain and nausea. Because there is not enough evidence on its possible benefits or harms, we will conduct a new study of 1000 adult cancer patients to compare people who use CAC with those who do not use CAC. Our study will provide new information to educate individuals and their healthcare providers about whether to considering using CAC alongside other conventional ways to manage cancer-related symptoms.

PI_NAMEs: HAQUE, REINA ;POTOSKY, ARNOLD L (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Adjuvant;Adult;Affect;Age;Alcohols;Anxiety;appetite loss;Biological Response Modifier Therapy;California;cancer care;Cancer Patient;cancer therapy;Cannabidiol;cannabinoid drug;cannabinoid treatment;Cannabinoids;Cannabis;care delivery;care outcomes;Caring;chemotherapy;chronic pain;chronic pain management;Clinical;Clinical Data;cognitive function;Cohort Studies;Colorectal;Colorectal Cancer;Communities;Community Health;comorbidity;Complementary Health;Consumption;Data;Data Set;Diagnosis;Drug Interactions;Drug Prescriptions;Educational workshop;Effectiveness;Electronic Health Record;Eligibility Determination;Emotional;emotional functioning;Enrollment;Ensure;evidence base;experience;follow-up;Fracture;health care settings;Health Personnel;health plan;health related quality of life;Healthcare;improved;Individual;infection rate;infection risk;Ingestion;Inhalation;Injury;instrument;Investigation;Knowledge;Legal;Literature;Longitudinal, observational study;Malignant Neoplasms;marijuana legalization;marijuana use;marijuana use disorder;Measures;Mediating;Mediation;Medical;Memory;Mental Depression;National Cancer Institute;Nausea;Nausea and Vomiting;neoplasm registry;Newly Diagnosed;Non-Hodgkin's Lymphoma;Non-Small-Cell Lung Carcinoma;Observational Study;Oncologist;Oncology;Opioid;opioid use;Pain;Pain management;Palliative Care;Participant;Patient Outcomes Assessments;Patients;Persons;Physical Function;Policies;prescription opioid;prospective;Provider;Psychometrics;Recommendation;Recording of previous events;Reporting;Research;response;Risk;Safety;Sales;sex;Sleep disturbances;Sleeplessness;Social Functioning;Source;Subgroup;Surveys;symptom management;Symptoms;Tobacco use;Validity of Self Report

PROJECT_TITLE: Longitudinal assessment of benefits and harms of cannabis use among community-based cancer patients during initial cancer treatment


NIH_SPENDING_CATS: Cancer;Data Science

PI_NAMEs: PLEVRITIS, SYLVIA KATINA (contact)

PROJECT_TERMS: Address;Administrator;anti-cancer research;Award;Cancer Biology;Cancer Center;Collaborations;Communication;Communities;community engagement;Complex;Computational Science;Conflict of Interest;Consensus;Data;data access;data centers;data management;Data Science;Data Set;design;diversity and inclusion;Effectiveness;Engineering;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Fostering;Funding;Future;Generations;Goals;Guidelines;Immune;innovation;Institution;Interdisciplinary Study;Justice;Learning;Life Experience;Malignant Neoplasms;member;Minority;molecular oncology;Monitor;multidisciplinary;National Cancer Advisory Board;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;operation;organizational structure;outreach;Performance;Pilot Projects;Process;Productivity;programs;Recommendation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Services;Site;statistics;Systems Biology;tool;Training;training opportunity;tumor;Tumor Biology;United States National Institutes of Health;Universities;Voting;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: SCHABATH, MATTHEW B. (contact)

PROJECT_TERMS: Active Learning;Address;assigned female at birth;Attitude;Automobile Driving;Behavior;Behavioral;Birth;Body part;Cancer Center;cancer health disparity;Caring;Cervical Cancer Education;cervical cancer prevention;Cervical Cancer Screening;cisgender;Clinical;Collaborations;Communities;Competence;Data;design;disease disparity;Disparity;effective intervention;Effectiveness of Interventions;effectiveness testing;Emotional;ethnic minority;Ethnic Origin;Ethnic Population;Exhibits;experience;Feasibility Studies;Florida;Fostering;Funding;Gender;gender affirmation;gender expression;Gender Identity;gender minority;Guidelines;health disparity;Health Knowledge Attitudes Practice;Health Personnel;Health Sciences;Healthcare;high risk;Hispanic Populations;implementation measures;implementation outcomes;implementation strategy;improved;Incidence;Individual;Interdisciplinary Study;intersectionality;Intervention;intervention effect;Interview;Knowledge;Latino Population;Latinx;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;man;Masculine;Measures;Medical Education;medical schools;Medical Students;Modeling;Nature;nonbinary;online intervention;Participant;Patient Self-Report;Patient Simulation;Patients;Persons;Pilot Projects;Politics;Population;Prevention;Prevention Guidelines;Provider;provider behavior;Puerto Rico;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;screening;Screening for cancer;Services;simulation;skills;social;social cognitive theory;Standardization;Stigmatization;student training;Testing;theories;tool;transgender men;Treatment Efficacy;Universities;women patients;Work

PROJECT_TITLE: Pilot Project 1: Testing the effectiveness of an intervention to foster cervical cancer screening promotion for Latinx trans men among medical students


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The Translational Research Center includes a multidisciplinary team of clinical and translational researchers who will leverage a unique active prospective (in-liver cancer surveillance) cohort of patients with cirrhosis to develop and validate methods for risk stratification and early detection of liver cancer.

PI_NAMEs: CHHATWAL, JAGPREET ;EL-SERAG, HASHEM B;KANWAL, FASIHA  (contact);KOAY, EUGENE J

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Abdomen;AFP gene;African American population;Algorithms;Applications Grants;Artificial Intelligence;Behavioral;biobank;Biological;Biological Markers;Biological Specimen Banks;biomarker panel;biomarker validation;Blinded;Blood;blood-based biomarker;cancer biomarkers;Cancer Detection;Center for Translational Science Activities;Cirrhosis;Clinical;Clinical Data;clinical decision-making;clinical practice;Clinical/Radiologic;cohort;Collaborations;comparative;cost;cost effectiveness;Costs and Benefits;Data;Decision Analysis;design;detection sensitivity;Development;Dimensions;Disease;DNA;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Enrollment;Ensure;Equilibrium;ethnic diversity;Evaluation;Fatty acid glycerol esters;Fibrosis;follow-up;Funding;Future;Genetic Markers;Germ Lines;Goals;Guidelines;Healthcare Systems;Hepatitis C;Hepatitis C virus;high risk;Hispanic Populations;Image;image archival system;imaging biomarker;improved;Infrastructure;innovation;Institution;Liver;Liver diseases;Liver Fibrosis;liver function;liver imaging;machine learning pipeline;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant Neoplasms;Maps;mathematical model;Metabolic Marker;Methods;Modality;Modeling;Morbidity - disease rate;mortality;multidisciplinary;muscle form;neoplasm registry;Nodule;non-alcoholic fatty liver disease;novel;Patients;Pattern;Performance;Phase;phase 3 study;Portal Hypertension;Primary carcinoma of the liver cells;Productivity;programs;prospective;Prospective cohort;racial diversity;radiomics;recruit;Reporting;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;risk stratification;sample collection;Sampling;Science;screening;Screening for cancer;Screening for Hepatocellular Cancer;Serum;Severities;Site;Societies;Source;Spleen;subcutaneous;Subgroup;surveillance strategy;Surveys;Testing;Texas;tool;translational approach;translational scientist;ultrasound;Underrepresented Populations;virtual;Visceral fat;Visit;Work

PROJECT_TITLE: Risk Stratification for and Early Detection of Liver Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lymphatic Research

PI_NAMEs: ENGLEMAN, EDGAR G.  (contact)

PROJECT_TERMS: Adaptive Immune System;Algorithms;Anatomy;Architecture;Atypical lymphocyte;Automobile Driving;Back;Biological Markers;Blocking Antibodies;cancer cell;Cell Communication;Cells;Chronology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computing Methodologies;conditioning;cytokine;Cytometry;Data;data integration;Development;Diagnosis;Disease;Disease Progression;Distal;Distant;Distant Metastasis;Education;Flow Cytometry;Gene Expression Profile;Genes;Genetic Transcription;Head and Neck Cancer;high dimensionality;Human;Image;imaging platform;Immune;Immune Evasion;Immune Tolerance;implantation;Kinetics;Knockout Mice;Label;Leukocyte Trafficking;Leukocytes;Lymph Node Involvement;lymph nodes;Lymphatic;Malignant Neoplasms;markov model;Mediating;Metastatic Neoplasm to Lymph Nodes;migration;Modeling;mouse model;Mus;Nature;Neighborhoods;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nodal;Non-Small-Cell Lung Carcinoma;novel;Patients;Population;Predisposition;prevent;Prevention;Primary Neoplasm;Process;programs;Property;Regulatory T-Lymphocyte;Role;single-cell RNA sequencing;Site;Solid;Stromal Cells;Study models;Systems Biology;therapy design;Tissues;trafficking;transcriptomics;tumor;Tumor Biology;Tumor Promotion;Tumor-infiltrating immune cells

PROJECT_TITLE: Project 1 Mouse Models Analysis


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Sepsis is one of the most common causes of hospitalization, healthcare costs, and mortality in the United States. Despite existing evidence-based guidelines that promote timely delivery of antibiotics to appropriate patients with sepsis, diagnostic challenges often lead to harmful diagnostic errors We propose to leverage tools from safety and implementation science to address the fundamental knowledge gap in understanding and applying best practices for sepsis diagnostic safety and quality.

PI_NAMEs: BIRKEN, SARAH ABIGAIL;KOWALKOWSKI, MARC ;TAYLOR, STEPHANIE P (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Diagnostic  Safety and Quality Optimization in Sepsis (DISQOS)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: GWEDE, CLEMENT K. (contact)

PROJECT_TERMS: Accountability;Advanced Malignant Neoplasm;Advisory Committees;Area;Cancer Center;cancer health disparity;Cancer health equity;Collaborations;Collection;Communication;Community Outreach;Data;Development;Education and Outreach;effectiveness evaluation;Elements;Ensure;Evaluation;Evolution;Feedback;flexibility;Florida;Funding;Goals;Grant;Growth;Health Sciences;Hispanic;improved;Information Systems;innovation;Institution;Journals;Knowledge;Latino Population;Logic;meetings;member;Modeling;Monitor;National Cancer Institute;novel;Online Systems;Outcome;Output;Process;programs;Progress Reports;Publications;Puerto Rico;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Science;special interest group;Strategic Planning;Structure;success;Surveys;Time;Universities;Update;Work

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Substance Misuse

ORG_DEPT: SURGERY

PHR: Project narrative Consuming alcohol can have effects, good and bad, on cardiovascular disease that is the leading cause of death and disability. Our study will investigate the biphasic effects of alcohol on endothelial cell activation and differentiation, processes believed critical to the pathology underlying cardiovascular disease. Deciphering the precise cellular and molecular mechanisms mediating alcohol’s cardiovascular health effects will fill a crucial knowledge gap and is highly significant from both basic science and clinical viewpoints.

PI_NAMEs: REDMOND, EILEEN M. (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Activities of Daily Living;Affect;Alcohol consumption;alcohol effect;alcohol measurement;Alcohols;antagonist;Arterial Fatty Streak;arterial stiffness;Arteriosclerosis;Basic Science;Behavior;binge drinking;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular health;Cause of Death;Cell Adhesion Molecules;cell type;Cells;Cessation of life;Chronic;Clinical;Color;Consumption;cytokine;Data;Development;disability;Disease Progression;Disease regression;Dose;drinking;drinking behavior;Endothelial Cells;endothelial dysfunction;Endothelium;epidemiology study;Foundations;gain of function;Guidelines;Homeostasis;Human;Hyperplasia;Hypoxia;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;interest;intima media;intimal medial thickening;Knock-in Mouse;Knock-out;Knowledge;Laboratory Study;Lesion;loss of function;Medial;Mediating;Mesenchymal;migration;mimetics;Modeling;modifiable behavior;Molecular;Morbidity - disease rate;mortality;mouse model;Myocardial Infarction;Myofibroblast;notch protein;novel;novel therapeutics;Pathologic;Pathology;Phase;Phenotype;Prevention;Process;Proliferating;protective effect;Published Comment;Regulation;Reporter;response;Risk Factors;Role;Science;Severities;Shapes;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stimulus;Stroke;Testing;transcriptomics;transdifferentiation;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Biphasic Regulation of Endothelial Transdifferentiation by Alcohol and Its Impact on Vascular Disease

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lymphatic Research;Rare Diseases

PROJECT_TERMS: Architecture;Awareness;biocomputing;Biological Markers;Biology;cancer cell;Cancer Etiology;Cancer Patient;Cell Communication;Cell model;cell type;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Data;Disseminated Malignant Neoplasm;Drug Targeting;Ecosystem;Endothelial Cells;Environment;Epithelium;Extracellular Matrix;Formalin;Freezing;Genes;Genetic Transcription;Growth;Head and Neck Squamous Cell Carcinoma;Heterogeneity;Host Defense Mechanism;Human;human model;human tissue;imaging platform;Immune;Immune system;Immune Tolerance;in situ imaging;insight;Link;Lung Adenocarcinoma;Lymph Node Involvement;Lymph Node Tissue;lymph nodes;Malignant - descriptor;Malignant Neoplasms;Maps;markov model;Metastatic Neoplasm to Lymph Nodes;Modeling;Molecular Analysis;mouse model;Neoplasm Metastasis;neoplastic cell;novel;Organ;Organoids;Paraffin Embedding;Patients;Pattern;Positive Lymph Node;pre-clinical;Primary Neoplasm;Process;Property;Proteomics;Research;Role;Sampling;Sentinel Lymph Node;Series;single cell sequencing;single-cell RNA sequencing;Site;Solid;spatial integration;spatiotemporal;Specimen;Stromal Cells;Stromal Neoplasm;Systems Biology;Technology;temporal measurement;Testing;Time;Tissues;treatment strategy;tumor;Tumor Biology;tumor microenvironment

PROJECT_TITLE: Project 2 Human Tumor Analysis


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Social Determinants of Health

PI_NAMEs: WRIGHT, KENNETH LYNN (contact)

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;Basic Cancer Research;Biometry;Bone Marrow Transplantation;Cancer Center;cancer clinical trial;cancer health disparity;cancer therapy;career;Career Choice;career development;Career Mobility;Caring;Clinical;Clinical Oncology;clinical practice;clinical training;Clinical Trials;Communities;cultural competence;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Education;education research;Educational workshop;Effectiveness;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship Program;Florida;Goals;graduate school;Grant;Health Disparities Research;health disparity;Health Sciences;Hematology;Hispanic;Immersion;improved;Industry;interest;Interest Group;investigator training;Island;Latino;Latino Population;Malignant Neoplasms;Medical;Medical Students;Mentors;Mentorship;minority health;Needs Assessment;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Participant;patient engagement;peer coaching;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;programs;Puerto Rican;Puerto Rico;recruit;Research;Research Personnel;Residencies;Rotation;Scholarship;Science, Technology, Engineering and Mathematics;Scientist;senior faculty;Series;Site;STEM research;Students;success;summer research;Surgical Oncology;Training;tumor;undergraduate student;Universities;Urology;Vision;Writing

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Precision Medicine

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative ‘Personalized’ drugs for cancer exploit specific alterations in the cancer cell, for example a mutated, overexpressed, or fused protein that is present in tumor cells but not normal cells, but only a handful of such drugs are available and the pace of development is slow. We have implemented a strategy that enables discovery of novel compounds that are selective for certain cancer subtypes, leading to 4 of our anticancer drugs moving toward clinical trials in the last 15 years. As described herein, we will now accelerate this discovery platform, utilizing a novel compound collection biased for selective anticancer activity; this strategy will allow us and others to discover and develop scores of new cancer drugs that are matched to specific molecular defects in a patient’s tumor.

PI_NAMEs: HERGENROTHER, PAUL  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acceleration;Animal Model;anti-cancer;anticancer activity;Antineoplastic Agents;Biological;cancer cell;Cancer cell line;Cancer Patient;cancer subtypes;cancer therapy;cancer type;Cell Culture Techniques;Cell Line;cell type;Cessation of life;Chimeric Proteins;Clinical;Clinical Trials;Collection;Complex;Defect;Development;drug discovery;Drug Kinetics;Drug Targeting;efficacy evaluation;efficacy study;Epidermal Growth Factor Receptor;experience;experimental study;Gleevec;Human;Imatinib;Immune system;Licensing;Malignant Neoplasms;Methods;Molecular;Mutate;Mutation;neoplastic cell;Normal Cell;novel;novel anticancer drug;novel strategies;Oncology;Output;overexpression;Patients;personalized medicine;Pharmaceutical Chemistry;Pharmaceutical Preparations;precision drugs;success;targeted treatment;Toxicology;Translations;tumor;Vision;Work

PROJECT_TITLE: Developing a Suite of Targeted Anticancer Drugs


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GENTLES, ANDREW J. (contact)

PROJECT_TERMS: anti-cancer research;Area;Cancer Biology;career;Collaborations;Communities;Data;Documentation;Education;Educational workshop;effectiveness evaluation;Environment;Evaluation;Event;experience;Feedback;Fostering;high school;Immune;Institution;Link;Malignant Neoplasms;member;Mentorship;Methodology;Modeling;novel;outreach;Pilot Projects;posters;Process;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Resources;response;Series;Surveys;symposium;Systems Biology;Techniques;tool;Training;tumor;Tumor Biology;Underrepresented Populations;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHRISTY, SHANNON MARIE (contact)

PROJECT_TERMS: Address;Awareness;Behavior;bilingualism;biobank;Biologic Characteristic;Cancer Burden;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Characteristics;Communication;Communities;community advisory board;community collaboration;community engagement;Community Health Education;community organizations;Community Outreach;Community Participation;community partners;community research;Cuban;Early Diagnosis;Education and Outreach;Educational Activities;Educational Curriculum;Equity;ethnic minority population;Ethnic Population;Event;evidence base;Evidence based program;Feedback;Florida;Genetic Counseling;Genetic Risk;Goals;Health;Health Disparities Research;Health Sciences;high risk;Hispanic;improved;Individual;interest;intervention refinement;Knowledge;Latino;Latino Population;Malignant Neoplasms;member;Mexican;outreach;Participant;Patient Recruitments;Persons;Pilot Projects;Population;preference;Prevention;programs;promoter;Puerto Rican;Puerto Rico;racial minority population;recruit;Reporting;Research;Research Activity;research data dissemination;Research Personnel;Research Priority;Research Project Grants;Research Support;screening;Screening for cancer;Skin Cancer;social culture;Source;success;telephone based;tool;Training;training opportunity;Translational Research;Underserved Population;United States;Universities;virtual;Woman;Work


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Lung;Lung Cancer;Lymphatic Research;Rare Diseases

PI_NAMEs: SHRAGER, JOSEPH B (contact)

PROJECT_TERMS: analysis pipeline;Archives;Biological Assay;biological specimen archives;Biological Specimen Banks;Cancer Etiology;cancer type;Cell Communication;cell type;Cells;Cessation of life;Clinical;cohort;Communities;computerized data processing;computerized tools;Data;data repository;Data Set;Data Sources;Databases;Deposition;Development;Distant Metastasis;Ensure;Exhibits;Extracellular Matrix;Fibroblasts;follow-up;Formalin;Freezing;Fresh Tissue;Gene Expression;Gene Expression Profile;Genomics;Goals;Head and Neck Cancer;head and neck cancer patient;Health Insurance Portability and Accountability Act;Human;human tissue;Image;Immune;Immune Tolerance;Immunity;Individual;Ink;insight;Link;Location;lymph nodes;machine learning algorithm;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Meta-Analysis;Metastatic Neoplasm to Lymph Nodes;Methods;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Output;Paraffin Embedding;Patients;Pattern;Phenotype;Positive Lymph Node;Primary Neoplasm;Procedures;Process;prognostic significance;Proteomics;Quality Control;reconstruction;Recurrence;Reporting;repository;Reproducibility;Research Personnel;Research Project Grants;Sampling;single-cell RNA sequencing;Specimen;Stains;Standardization;Systems Biology;Tissue Microarray;Tissues;transcriptomics;tumor;Tumor Biology;tumor microenvironment;Validation;Work

PROJECT_TITLE: Biospecimen and Data Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prescription Drug Misuse;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Opioid exposure and withdrawal during early life can cause long-term neurological and psychiatric problems. We will investigate how opioids affect the septum, a brain structure linked to addiction and stress, to gain a deeper understanding of the cellular, molecular, and neural circuit changes caused by opioid exposure.

PI_NAMEs: HARWELL, COREY C (contact);STUBER, GARRET D

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Adult;Affect;Animal Model;Atlases;Aversive Stimulus;Behavior;Behavioral;Brain;Calcium;Catalogs;Cell Nucleus;cell type;Cells;Child;Cognitive;Cognitive deficits;Complex;course development;Data;data integration;Desire for food;Development;drug reward;drug seeking behavior;Electrophysiology (science);Embryo;experimental study;Exposure to;fentanyl abuse;fentanyl exposure;fetal opioid exposure;Genetic Transcription;gliogenesis;Image;in vivo;Infant;insight;Knowledge;Lateral;Life;Link;mature animal;Measures;Mediating;Molecular;mouse model;multimodal data;Mus;Neonatal Abstinence Syndrome;neural;neural circuit;neuroadaptation;neurodevelopment;neurogenesis;Neuroglia;Neurologic;Neurons;neurophysiology;Opiate Addiction;Opioid;opioid exposure;opioid withdrawal;Pattern;Perinatal;Perinatal Exposure;Pharmaceutical Preparations;Play;postnatal development;Pregnancy loss;Pregnant Women;programs;Property;Puberty;Rewards;Risk;Role;single nucleus RNA-sequencing;Slice;stillbirth;Stress;Structure;Subgroup;Synaptic Transmission;synaptogenesis;Testing;Time;transcriptomics;Transgenic Mice;two-photon;Work

PROJECT_TITLE: The impact of early life opioid exposure on the molecular and functional trajectories of septal cell types


ORG_DEPT: PHARMACOLOGY

PHR: Despite significant improvements in cancer outcomes over the past several decades, metastasis continues to be the primary cause of cancer-related death, as exemplified for bladder cancer. Indeed, most patients with non-muscle invasive bladder cancer and at least half of those with muscle-invasive bladder cancer can expect to be cured (5-year survival ~90% and ~50%, respectively), whereas most patients with metastatic bladder cancer will succumb to the disease within a few years (5-year survival ~15%). My research utilizes novel in vivo models to elucidate the biological processes and molecular mechanisms underlying metastatic bladder cancer, with the translational goal of identifying new therapeutic targets that may improve patient outcomes.

PI_NAMEs: ABATE-SHEN, CORY  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: actionable mutation;Algorithms;ARID1A gene;biobank;Biological Assay;Biological Process;Biology;Bladder;Cancer Etiology;Cancer Patient;candidate identification;Carcinogens;Cells;Cessation of life;Computational algorithm;Data;Disease;Disease Outcome;Dose;driver mutation;drug candidate;Drug Targeting;Epigenetic Process;Evolution;Foundations;Genetically Engineered Mouse;Goals;Health;Human;improved;in vitro Model;in vivo;in vivo Model;Incidence;Investigation;longitudinal analysis;loss of function;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Metastatic to;Modeling;Molecular;Molecular Analysis;Mus;muscle invasive bladder cancer;Neoplasm Metastasis;new therapeutic target;Nitrosamines;non-muscle invasive bladder cancer;novel;novel strategies;novel therapeutics;Organ;Organoids;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pre-clinical;Reporter;Research;single-cell RNA sequencing;Site;System;Systems Biology;TP53 gene;translational goal;tumor;tumor microenvironment;tumorigenesis;United States

PROJECT_TITLE: Investigating mechanisms of bladder cancer metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]