NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Women's Health Research

PHR: Project 2 Narrative: Project 2 will begin to identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (etVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD). We will evaluate a sample of 80 adults with recurrent MDD unmedicated (ages 51- 64, equally divided by sex) randomized to receive active or sham expiratory-gated tVNS during a functional magnetic resonance imaging (fMRI) session of a mild visual stress challenge designed to elicit a sympatho- excitatory state, with simultaneous mood and physiological assessments of steroid hormones and dynamic cardiovagal heart rate variability. We hypothesize that etVNS will effectively modulate, in a sex-dependent manner, specific brainstem-cortical pathways of the stress circuitry and attenuate physiological deficits in MDD. Results will contribute to future development of etVNS as a novel non-pharmacologic therapeutic for MDD.

PROJECT_TERMS: Adult;Adult Children;advanced analytics;Age;Algorithms;Amygdaloid structure;Anatomy;Anterior;antidepressant effect;Anxiety;Arousal;Attenuated;Autonomic Dysfunction;Autonomic nervous system;Baroreflex;Behavioral;biological adaptation to stress;Blood Pressure;Blood Vessels;Brain;brain circuitry;Brain imaging;Brain region;Brain Stem;Cardiac;Cardiovascular Physiology;cardiovascular risk factor;Cell Nucleus;Clinical;Clinical Trials;Concha;Corticotropin-Releasing Hormone;cytokine;Data;depressive symptoms;design;Development;disability;Dorsal;Evaluation;expiration;external ear auricle;FDA approved;Fetal Development;Fiber;Functional Magnetic Resonance Imaging;Future;Goals;Health;heart rate variability;Hippocampus;Hormonal;Hormones;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;immune function;Immune response;Immunologic Markers;Implant;Inflammation;Inflammatory;interest;Intervention;late life;locus ceruleus structure;Major Depressive Disorder;male;Maps;Measurement;men;Methods;middle age;Mission;Modeling;mood regulation;Moods;Morbidity - disease rate;Motor;Nerve;Neural Pathways;Neuroanatomy;Neurons;neuroregulation;novel;nucleus ambiguus;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Peripheral;Physiological;Physiology;Population;Prefrontal Cortex;prenatal stress;Process;Randomized;raphe nuclei;Recurrence;Regulation;Resistance;Respiration;response;Risk;Sampling;Sampling Studies;sex;Sex Differences;sexual dimorphism;Sexual Dysfunction;side effect;Site;Skin;steroid hormone;Stress;symptomatology;Synapses;System;Techniques;Therapeutic;Time;transcutaneous stimulation;Translations;vagus nerve stimulation;Vagus nerve structure;Visual;Woman;Work

PROJECT_TITLE: Sex-Dependent Impact of Transcutaneous Vagal Nerve Stimulation on the Stress Response Circuitry and Autonomic Dysregulation in Major Depression


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN ANTONIO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE:  This PREP program (UTHealth-LINK) is designed to train and prepare students who have completed the undergraduate degree but who, for a variety of reasons, are underprepared for direct acceptance into doctoral training programs. Through sustained research activities, academic preparation and career planning, students completing this program will be exquisitely prepared for the rigors of demanding graduate programs.

PI_NAMEs: HOPP, SARAH CHRISTINE;OYAJOBI, BABATUNDE OLUKAYODE;RAABE, TIMOTHY D. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: academic preparation;Academic Training;Address;Admission activity;Adopted;Area;Award;Bachelor's Degree;Biomedical Research;bridge to the doctorate;Capital;career;career awareness;Cities;cohort;college;community engagement;Country;Critical Thinking;Decision Making;design;Destinations;Development Plans;Diamond;Discipline;Doctor of Philosophy;Education;Educational Status;Educational workshop;Enrollment;Environment;evidence base;expectation;experience;Fellowship;Funding;Goals;Graduate Education;graduate school;graduate student;Grant;Health;Healthcare;Hispanic Populations;Historically Black Colleges and Universities;Individual;Inosine Diphosphate;Institution;Internet;Journals;Link;matriculation;Measurable;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Minority-Serving Institution;Mission;Missouri;Motivation;National Institute of General Medical Sciences;Outcome;Positioning Attribute;Postbaccalaureate;Preparation;Privatization;Productivity;programs;Psychosocial Factor;Publishing;Qualifying;Readiness;recruit;Recruitment Activity;Regimen;Research;Research Activity;Research Training;Science;Scientist;Self Efficacy;Social Network;Standardization;Stereotyping;Student Selections;student training;Students;success;symposium;synergism;System;Talents;tenure track;Texas;Time;Training;Training Programs;tribal college;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Visit;Writing

PROJECT_TITLE: UTHealth-LINK- A PREP program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project will identify the cellular and physiological neural pathways whereby prenatal overexposure to the stress hormone, glucocorticoids, cause long-term, sex-selective changes in adult anxiety- and depressive-like behaviors, hormonal and autonomic nervous system responses to stress. Developmental programming is the permanent adaptation of the fetus to changing environmental signals in utero. These studies will identify the brain circuitry underlying the sex-biased developmental programming of behavioral, endocrine and autonomic responses in adulthood and address potential therapeutic mechanisms and approaches whereby these changes can be ameliorated in adulthood.

PI_NAMEs: HANDA, ROBERT J (contact)

PROJECT_TERMS: Address;Adult;Adult Children;Adult women;Agonist;Angiotensin II;Animals;antagonist;Anxiety;Area;Autonomic nervous system;Behavior;Behavioral;Brain;brain circuitry;brain control;Brain region;Brain Stem;Cell Nucleus;cell type;Cells;Coupled;CRH gene;Data;depressive symptoms;designer receptors exclusively activated by designer drugs;Development;Dexamethasone;Disease;Disproportionately impacts women;Endocrine;Environment;environmental change;Equilibrium;Exposure to;fetal;fetal programming;Fetus;Functional disorder;Gene Expression;genetic approach;Genetic Models;Glucocorticoids;Goals;Heart Rate;heart rate variability;Hormonal;Hormone Responsive;Hormone secretion;Hormones;Hypothalamic structure;IGF1R gene;Immune;In Situ Hybridization;in utero;Inflammation;Insulin-Like-Growth Factor I Receptor;Lateral;Major Depressive Disorder;male;Malnutrition;Measures;Mediator;Messenger RNA;mouse genetics;mouse model;Mus;nano-string;neonate;Nerve;Nervous System control;Nervous System Physiology;Neural Pathways;neurodevelopment;Neurons;Neuropeptides;Neurophysiology - biologic function;Neurosecretory Systems;Neurotransmitters;offspring;Oxytocin Receptor;Pathway interactions;Physiological;Physiology;Population;Pregnancy;pregnant;prenatal;prenatal exposure;prenatal stress;pressure;programs;Rattus;receptor;Recombinant adeno-associated virus (rAAV);Renin-Angiotensin System;Reporter Genes;response;restraint;Role;sex;Sex Bias;Sex Differences;Signal Transduction;Stress;stress reactivity;Technology;Testing;Therapeutic;Tissues;TNF gene;Transgenic Mice;Viral Vector;Virion

PROJECT_TITLE: Sex differences in fetal programming by glucocorticoids: Adult hypothalamus and Autonomic Nervous System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT The major cell types of many of our internal organs, including the thyroid, thymus, lung, stomach, liver, pancreas, intestine and bladder arise from a common embryonic tissue called the gut endoderm. A rigorous understanding of how the gut endoderm normally forms, including knowledge of the origin of its resident cell populations, how these cell types are generated during embryonic development, and how they are diversified to form individual organs with distinct characteristics, will underpin logical efforts to understand the manifestation and progression of diseases in these vital internal organs, tissue regeneration potential and repair, as well as the progression and design new therapeutic strategies. The broad aim of this project is to use a combination of state-of-the-art embryological, genetic, single-cell genomic and imaging techniques to determine the origin and fate of the embryonic gut endoderm, and to investigate the cell behaviors driving its formation in the embryo.

PI_NAMEs: HADJANTONAKIS, ANNA-KATERINA  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Adult;analysis pipeline;Automobile Driving;Behavior;Binding;Biochemical;Biological Assay;Bladder;Body System;cell behavior;Cell Differentiation process;cell fate specification;Cell Lineage;cell type;Cells;Characteristics;Communication;design;Development;directed differentiation;disease model;Disease Progression;driving behavior;Ectoderm;Embryo;embryo tissue;Embryonic Development;Endoderm;Endoderm Cell;Epiblast;Epithelium;fetal;Gastrointestinal tract structure;gastrulation;Genetic;Genetic Transcription;Genomics;Germ Layers;Glean;Goals;Green Fluorescent Proteins;Homeostasis;Image;Image Analysis;imaging modality;Imaging Techniques;Individual;insight;intercalation;Intestines;Knowledge;Label;Light;Liver;Lung;Mammals;Maps;mature animal;Mediating;Memory;Mesoderm;Methods;microscopic imaging;Molecular;Morphogenesis;mouse model;Movement;Mus;novel;novel therapeutic intervention;Organ;Organoids;Pancreas;Population;Pregnancy;Process;prospective;public health relevance;rational design;regeneration potential;repaired;Reporter;Resolution;Respiratory System;screening;Series;single cell genomics;SOX17 gene;Specific qualifier value;Stomach;Technology;Therapeutic;Thymus Gland;Thyroid Gland;Time;tissue regeneration;Tissues;transcription factor;transcriptomics;Tube;Visceral;Visualization

PROJECT_TITLE: The gut endoderm: origin, formation and fate

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project seeks to define basic mechanisms of gastric tissue maintenance, and molecular pathways that initiate gastric disease. The findings will advance our knowledge of gastric stem cell regulation and our understanding of gene mutations that lead to dysregulated cellular proliferation in the human stomach.

PI_NAMEs: SAMUELSON, LINDA C. (contact)

PROJECT_TERMS: Address;adenoma;adult stem cell;Affect;Age;Alleles;Antral;APC gene;APC mutation;biobank;Cell Differentiation process;Cell Proliferation;cell type;Cells;Colectomy;Colon;Complement;Culture Media;Development;diagnostic criteria;Disease;Distal;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Exhibits;Familial Adenomatous Polyposis Syndrome;gastric organoids;Gastric Polyp;Gastric Tissue;gastrointestinal;Gastrointestinal tract structure;Gene Mutation;Genes;genetic analysis;Genetic Diseases;Genetic Models;Germ Lines;Growth;Homeostasis;Human;human disease;human tissue;Hyperplasia;Individual;Induced Mutation;insight;Knowledge;Maintenance;Malignant Neoplasms;Measures;Modeling;Molecular;mouse genetics;Mus;mutant;Mutation;novel;Organ;Organoids;Pathway interactions;patient response;Patients;pharmacologic;polyposis;Polyps;Pylorus;regenerative therapy;Regulation;response;Role;self-renewal;Signal Transduction;stem cell expansion;stem cell function;stem cell homeostasis;stem cell proliferation;stem cells;Stomach;Stomach Diseases;Testing;Tissue Expansion;Tissue Sample;Tissues;tumorigenesis;WNT Signaling Pathway

PROJECT_TITLE: Wnt Pathway Regulation of Gastric Stem Cell Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative This study focuses on childhood obesity prevention through a single behavioral target (reducing sugar- sweetened beverage consumption) among pre- and early adolescent youth. Key innovations include utilizing youth-produced narratives (stories) as a strategy to facilitate youth empowerment, parental engagement, and decreases in sugar-sweetened beverage consumption, as well as designing the intervention for integration within Boys and Girls Club setting.

PI_NAMEs: WANG, MONICA L. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Adolescent;Affect;Age;Behavior;behavior change;Behavior Therapy;Behavioral;Beverages;Body mass index;boys;cancer type;Caring;catalyst;Child;cluster randomized design;Collaborations;Communities;Complex;Consumption;Critical Thinking;Data;design;Development;Diabetes Mellitus;diabetes risk;Diet;dietary;Educational process of instructing;efficacy testing;empowerment;Energy Intake;Enrollment;ethnic diversity;ethnic minority;evidence base;Family;girls;Goals;Health;health empowerment;Heart Diseases;Home;Hypertension;improved;innovation;Intake;Intervention;intervention effect;Knowledge;Lead;Learning Skill;Life;Life Expectancy;Low income;Massachusetts;Measures;Mediator;minority children;Modeling;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Overweight;overweight child;Parents;Physical activity;Pilot Projects;pilot test;Positioning Attribute;preadolescence;prevent;primary outcome;programs;Randomized;Randomized, Controlled Trials;Research Design;Resources;Risk;Sampling;School-Age Population;Schools;secondary outcome;Site;skills;successful intervention;sugar;sweetened beverage;System;Target Populations;Testing;theories;therapy design;treatment as usual;Waiting Lists;Water consumption;Work;Youth

PROJECT_TITLE: Preventing Childhood Obesity Through Youth Empowerment: A Cluster RCT of the H2GO! Program

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

ORG_STATE: CA

PHR: PROJECT NARRATIVE Muscle stem cell exhaustion is one of the hallmarks of aging and leads to gradual impairment of tissue structure and function. Aged stem cells exhibit a decline in resilience, manifested as a reduced resistance to extrinsic and intrinsic stresses, rendering them more susceptible than young stem cells to processes leading to cell death. The main focus of the studies of this proposal is to explore the mechanisms that promote stem cell resilience, how those mechanisms decline with age, and interventions that may promote stem cell resilience in older individuals.

PI_NAMEs: RANDO, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acetylation;Address;Adult;Age;age related;age related changes;age related decline;aged;Aging;aging process;Attention;beta-Hydroxybutyrate;biological adaptation to stress;Blood;Caloric Restriction;Cell Aging;Cell Cycle;Cell Death;Cell Survival;Cells;cellular resilience;Cytoprotection;Data;decrease resilience;Diet;Dietary Intervention;Exhibits;Fasting;functional decline;Functional disorder;Genetic Models;Goals;hallmarks of aging;Heterogeneity;Histone Deacetylase;Histone Deacetylase Inhibitor;Homeostasis;Impairment;In Vitro;in vivo;Injury;Intermittent fasting;Intervention;ketogenic diet;Ketone Bodies;Ketosis;Knock-out;Laboratories;life span;Mediating;Mediator;Mitotic;Molecular;Molecular Profiling;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;Muscle satellite cell;muscular structure;new therapeutic target;notch protein;novel;Older Population;Outcome;Pathway interactions;Phenotype;phosphoproteomics;Population;Predisposition;preservation;prevent;Process;promote resilience;Publishing;regeneration potential;regenerative;Regenerative capacity;Rejuvenation;repaired;replication stress;resilience;resilience biomarker;Resistance;response;response to injury;Role;screening;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell exhaustion;stem cell population;stem cells;Stress;Structure;Testing;Time;Tissues;TP53 gene;Transgenic Organisms;Work

PROJECT_TITLE: Aging and Stem Cell Resilience

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Dietary Supplements;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: In vitro assays suggest that Vitamin A derivative, retinoic acid, regulates numerous metabolic genes which undergo profound changes in expression levels during metabolic transitions such as adaptation to starvation, or in response to insufficient insulin signaling in type I diabetes. However, remarkably little is known about the fate of vitamin A metabolism and retinoic acid levels during such transitions. Based on our preliminary data, we propose to test a hypothesis that the rate of retinoic acid biosynthesis is carefully adjusted during metabolic transitions to enable proper remodeling of hepatic energy metabolism, while in type 1 diabetes this mechanism fails thereby exacerbating the disease.

PI_NAMEs: KEDISHVILI, NATALIA Y (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adult;Affect;Anabolism;Bioinformatics;Biometry;Body Patterning;carbohydrate metabolism;Carnitine Palmitoyltransferase I;Cell Physiology;cell type;Circadian Rhythms;Data;Development;Diabetes Mellitus;Disease;Down-Regulation;Embryo;Embryonic Development;Energy Metabolism;Ensure;Enzymes;Event;Fasting;fatty acid oxidation;Fatty-acid synthase;Foundations;Gene Modified;Genes;Glucokinase;Goals;Health;Hepatic;Hour;in vitro Assay;insight;insulin signaling;Insulin-Dependent Diabetes Mellitus;ketogentic;Knowledge;Link;lipid metabolism;Liver;Mass Spectrum Analysis;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;metabolomics;Modeling;Molecular;mouse model;novel;Nuclear;Organism;Outcome;Outcome Study;Personal Satisfaction;Phosphoenolpyruvate Carboxylase;Physiology;Proteins;Proteomics;response;Retinoic Acid Receptor;Retinoids;Retinol dehydrogenase;Role;Signal Transduction;Starvation;stem;targeted treatment;Testing;therapeutically effective;Tissues;transcription factor;transcriptome sequencing;translational impact;Tretinoin;Up-Regulation;Vitamin A

PROJECT_TITLE: Hepatic retinoid metabolism and signaling in starvation and diabetes.

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Pneumonia and other acute inflammatory diseases of the lungs, such as the acute respiratory distress syndrome (ARDS), result in damage to the alveolar epithelium and endothelium. Alveolar macrophages are critical orchestrators of alveolar repair, however the mechanisms that underpin their function remain largely unknown. The objective of this proposal is to create a Program that will determine the factors that regulate macrophage function and determine how macrophage subsets contribute to lung repair. Achieving the goals of this proposal will enhance our understanding of lung repair and pave the way for new strategies to hasten recovery from lung injury.

PI_NAMEs: JANSSEN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar Macrophages;Apoptosis;Binding;Biology;Blood capillaries;Bronchoscopy;Calibration;cell injury;Cells;Citric Acid Cycle;Clinical Research;Data;Development;Embryonic Development;Endothelial Cells;Endothelium;Energy-Generating Resources;Epithelial Cells;Epithelium;Fibrosis;Glycolysis;Goals;Health;Heart;Human;Human Volunteers;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;injured;Life;Link;Lung;lung injury;lung repair;Macrophage;Metabolic;Metabolism;monocyte;Mucins;multidisciplinary;neutrophil;novel;Pathologic;Patients;Persons;Play;Pneumonia;programs;Proteins;receptor binding;Recovery;recruit;repair function;repaired;Research Personnel;Resolution;Role;self-renewal;sialic acid binding Ig-like lectin;Sialic Acids;Specimen;Stable Populations;System;Technology;Testing;tissue repair;Tissues;Transgenic Animals

PROJECT_TITLE: Lung Macrophage Programming in Acute Lung Injury


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Puerto Rico faces frequent power outages due to the damage caused by natural disasters to its electric grid, which can in turn negatively affect the aging population (≥50 years) who are more likely to have multiple chronic health conditions. Research has demonstrated that access to energy independence through direct access to solar power can have positive health impacts on the population. We propose to explore, from a multilevel perspective, the perceived barriers and facilitators for adopting energy independence as described by individuals, communities, and policy makers, while also documenting resilience related variables that can explain effective chronic disease management among aging populations in need of electricity-based therapeutic treatments (i.e., renal disease, respiratory diseases, diabetes).

PI_NAMEs: PADILLA, MARK B;RODRIGUEZ MADERA, SHEILLA LEE;VARAS-DIAZ, NELSON  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adopted;Affect;Aging;aging population;Altruism;American;Area;Caribbean region;Case Study;Categories;Cessation of life;Characteristics;Chronic;Chronic Disease;Climate;commune;Communities;community engagement;community organizations;comorbidity;Diabetes Mellitus;disaster resilience;Disasters;Disease;Disease Management;Disparity;Disparity population;Earthquakes;Electricity;Emotional;Enabling Factors;End stage renal failure;Energy-Generating Resources;Ethnography;Event;experience;extreme weather;Face;food marketing;Fostering;Funding;Geography;Government Agencies;Health;health disparity;health inequalities;Healthcare Systems;Hispanic Populations;Homes for the Aged;Hurricane;improved;Individual;Institution;Interruption;Intervention;Interview;Island;Kidney Diseases;Knowledge;Local Government;Location;Maps;member;Modeling;Morbidity - disease rate;mortality;Movement;multilevel analysis;Natural Disasters;Not Hispanic or Latino;optimism;Outcome;Patients;Persons;Policies;Policy Developments;Policy Maker;Population;population health;Positioning Attribute;Process;Pueblo Race;Puerto Rican;Puerto Rico;Recording of previous events;Recovery;Research;resilience;Respiratory Disease;response;Restaurants;Role;Rural;Sampling;Self Efficacy;Series;Solar Energy;Structure;Surveys;Technology;Therapeutic;Training;United States;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Disasters, solar energy, and chronic disease management in aging Puerto Ricans

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Autoimmune Disease;Dietary Supplements;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Vitamin B1 is indispensable for normal human health due to its involvement in oxidative energy metabolism/ATP production, reduction of oxidative stress, and mitochondrial function. Its deficiency occurs in conditions like IBD, sepsis and chronic alcoholism. Humans obtain the vitamin from exogenous sources (i. e., diet, and the gut microbiota). Our objectives are to understand the physiology/cell biology of vitamin B1 uptake along the intestinal tract and how pathophysiological conditions/factors affect the process. Results should assist in the designing of effective strategies to optimize vitamin B1 nutrition, and thus, improve health.

PI_NAMEs: SAID, HAMID M (contact)

PROJECT_TITLE: Absorption of vitamin B1 along the intestinal tract: Physiology, pathophysiology and cell biology aspects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This proposal seeks funding for the upcoming 14th, 15th, and 16th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research (AQL) and the associated workshops and pre- conference, taking place in 2021, 2023, and 2025. AQL is an important international scientific meeting specialized in translational research and methods for measurement and modeling of voice and speech. Special emphasis will be given to promoting young investigators and underrepresented populations, digital networks to support a more inclusive and equitable conference, and to develop a permanent AQL website to help disseminate AQL information.

PI_NAMEs: LOTT, DAVID G (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Area;Award;Biology;Carbon;career;Caring;Child;Child Support;Clinical;Collection;Colombia;Communities;cost;COVID-19 pandemic;Dedications;design;Development;digital;Disabled Persons;Discipline;Education;Educational workshop;empowerment;Engineering;Ensure;Environment;Equity;ethnic minority;Evaluation;Event;expectation;Family;Fees;Fostering;Funding;Future;Germany;Goals;Health;improved;interest;International;Leadership;Location;Logistics;Machine Learning;Measurement;Measures;meeting abstracts;meetings;member;Mentors;Methodology;Minority;Modeling;multidisciplinary;Occupations;Online Systems;Otolaryngology;outreach;Persons;Physics;posters;preservation;programs;racial minority;Recording of previous events;recruit;Request for Proposals;Research;Research Methodology;Research Personnel;Safety;Science;Scientist;social;South America;South Korea;Specialist;Speech;Speech Pathology;Stream;Student Selections;Students;symposium;translational progress;Translational Research;Travel;Underrepresented Populations;United States National Institutes of Health;Update;virtual;Voice;web site;Woman

PROJECT_TITLE: International Conference on Advances in Quantitative Laryngology,Voice and Speech Research (AQL)

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research evaluates DENV and ZIKV immunity in humans living in endemic and non-endemic settings. This knowledge is critical to understanding the potency, breadth, determinants and correlates of ZIKV and DENV immunity as well as effective evaluation and improvement of this vaccine that is critical to control this globally important disease. The results of this project are highly and directly relevant to the NIH’s mission fostering innovative research strategies to reduce the burden of illness and disease.

PI_NAMEs: MESSER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Antibodies;Antibody titer measurement;Antibody-mediated protection;arthropod-borne;Biological Assay;burden of illness;Cells;cohort;Cohort Studies;Collaborations;Communities;Complex;Data;Dengue;Dengue Vaccine;Dengue Virus;Dependence;Diagnostic;Disease;Disease Surveillance;Epidemic;Evaluation;Flavivirus;Fluorescence-Activated Cell Sorting;Fostering;Frequencies;Future;Human;Immune;Immunity;immunogenic;Immunologic Memory;improved;Individual;Infection;innovation;Knowledge;Label;Link;Maintenance;Memory;Memory B-Lymphocyte;Methods;Mission;Modeling;mosquito-borne;Natural Immunity;neutralizing antibody;Nicaragua;Nonstructural Protein;novel;Observational Study;Oregon;Pathogenicity;Peripheral Blood Mononuclear Cell;Peru;Play;Predisposition;Primary Infection;Property;prospective;Public Health;Puerto Rico;Research;response;Role;Sentinel;Serotyping;Serum;Specificity;System;Testing;Therapeutic;Time;transmission process;United States National Institutes of Health;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Variant;Viral Proteins;Virus;Work;World Health Organization;Zika Virus

PROJECT_TITLE: Flavivirus immunity in endemic and non-endemic human cohorts

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences;Prevention;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE There is a critical need for improved understanding of how modulation of the immune system affects Alzheimer's Disease and its treatment. The goal of this project is to engineer microglia, the specialized immune cells of the brain, to better understand their role in treating neurodegeneration. Completion of these studies will create the needed knowledge base to engineer microglia as a therapy for Alzheimer's Disease.

PI_NAMEs: BENNETT, FREDERICK ;GILL, SAAR  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Abeta clearance;abeta oligomer;Acute;Address;Affect;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;amyloid pathology;Antigen Receptors;Behavior;Behavioral Assay;Behavioral Symptoms;beta amyloid pathology;Binding;Biochemical;Biochemistry;Biology;Brain;brain cell;Cell Therapy;Cells;cellular engineering;Cellular immunotherapy;chemotherapy;chimeric antigen receptor;Chronic;Collaborations;CSF1R gene;cytokine;Data;design;Engineering;Engraftment;Ensure;Epitopes;Foundations;gain of function;Genetic;Gills;Gliosis;Goals;Histology;human disease;Hyperactive behavior;Immune;Immune system;immunoregulation;Immunotherapy;Impairment;improved;in vivo;individualized medicine;Inflammasome;Inflammatory;Inflammatory Response;Injections;Intravenous;Knowledge;knowledge base;Lead;loss of function;Macrophage;Measures;Methods;Microglia;Modeling;Monoclonal Antibodies;mouse model;Mus;Nerve Degeneration;neuroinflammation;neuropathology;Passive Immunization;Pathogenesis;Pathogenicity;Pathology;Patients;Phagocytes;Phagocytosis;prevent;Principal Investigator;programs;Proteins;Research;Resource Sharing;response;Role;Signal Transduction;Specimen;targeted treatment;Testing;Therapeutic;Tissues;tool;transcriptomics;Transplantation;TREM2 gene;uptake

PROJECT_TITLE: Amyloid Beta CAR Macrophages: a cell engineering strategy to clear pathogenic proteins


NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Exposure to Particulate Matter (PM) metals during pregnancy is known to be harmful to both mother and the new born. Cardiovascular disease (CVD) is one such harmful effect of exposure to PM metals. In the natural environment we are always exposed to mixtures of chemicals with different toxicities. Unfortunately, methods of identifying those mixtures are limited. In this K01 application, we are proposing a novel method of pollutant mixtures identification and we will investigate their association with CVD risk factors.

PI_NAMEs: IBRAHIMOU, BOUBAKARI  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Air Pollutants;Air Pollution;Aluminum;Bayesian Analysis;Biological;Biological Markers;Biometry;Black race;Cadmium;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Caucasians;Characteristics;Chemicals;Child;Child Development;Child Mortality;Clinical;Complex;Data;Development Plans;Disease;Embryology;Environment;environmental toxicology;Equation;Ethnic Origin;Etiology;Exposure to;Factor Analysis;Female of child bearing age;Fetal Development;Fetal Growth;Fetus;flexibility;Florida;Funding;Future;Geographic Information Systems;Gestational Diabetes;Goals;Growth and Development function;Health;health disparity;Heavy Metals;Hispanic;Hospitals;Human;infant morbidity/mortality;Infant Mortality;Inhalation;Intervention;Latino;Lead;Linear Models;Literature;Logistic Regressions;Mediating;Mediator;Mentors;Mercury;Metal exposure;Metals;Methods;Minority;Minority Groups;Minority Women;Modeling;Morbidity - disease rate;mortality;Mothers;novel;Particulate Matter;Pathway interactions;Physician's Role;pollutant;Pollution;Power Plants;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy hypertension;Pregnancy Trimesters;Pregnant Women;prenatal;Prevalence;programs;Public Health;Race;racial disparity;Regression Analysis;Regulation;Research;Research Project Grants;Risk;Risk Assessment;Risk Factors;Silicon;Source;spatiotemporal;Statistical Methods;Testing;Time;tool;Toxic effect;Training;United States Environmental Protection Agency;Vanadium;Vulnerable Populations;waste treatment;Zinc;Zoran

PROJECT_TITLE: Particulate Matter (PM) Metals and Racial Disparity in Cardiovascular (CVD) Risk Factors

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE There is a need for rapid, accurate and sensitive assays or diagnostic platforms that can confirm exposure and predict acute and delayed radiation injury to different organs and tissues. While metabolomics has been proven effective in identifying biomarkers of acute radiation injury, there is a paucity of studies focused on circulating biomarkers that predict the development of organ-specific or delayed radiation injuries. This project aims to identify metabolic biomarkers of radiation injury to three major organs at risk: kidney, heart, and brain following exposure to low- and high-linear energy transfer radiation, and develop a kit-based assay for assessing and predicting injury in these organ systems.

PI_NAMEs: BOERMA, MARJAN  (contact);CHEEMA, AMRITA KAUR

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Acute;Adult women;Algorithmic Software;Algorithms;Animal Model;Bioinformatics;Biological Assay;Biological Markers;biomarker development;biomarker identification;biomarker panel;biomarker validation;Biometry;biosignature;Body System;Brain;circulating biomarkers;classification algorithm;Clinical;clinical care;clinical diagnosis;Clinical Management;clinical translation;cohort;Collaborations;Data;Decision Analysis;Development;diagnostic platform;Early Diagnosis;Early identification;Exposure to;Female;Foundations;Future;Gamma Rays;General Population;Genetic;good laboratory practice;Guidelines;Heart;High-LET Radiation;improved;in vivo;Inbreeding;indexing;Individual;Injury;Injury to Kidney;Interdisciplinary Study;Ionizing radiation;irradiation;Kidney;Late Effects;Leg;Linear Energy Transfer;lipidomics;Low Dose Radiation;Lung;male;Mass Spectrum Analysis;Metabolic;metabolomics;minimally invasive;Modeling;multiple reaction monitoring;Neutrons;nonhuman primate;novel;Nuclear Warfare;Organ;organ growth;organ injury;Outcome;Plasma;Practice Guidelines;prediction algorithm;predictive marker;predictive panel;predictive test;Predictive Value;Predisposition;Procedures;prototype;Radiation;Radiation Accidents;Radiation exposure;Radiation Injuries;radiation risk;Radiobiology;Rattus;Research Design;Resolution;Risk;Risk Assessment;Roentgen Rays;Sampling;Science;sex;software development;Source;Specificity;Sprague-Dawley Rats;stable isotope;Symptoms;Terrorism;Testing;Time;tissue injury;Tissues;United States Food and Drug Administration;Urine;Validation;validation studies;Water;Whole-Body Irradiation;Work

PROJECT_TITLE: Development of a minimally invasive biomarker assay to detect delayed radiation injury


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Public Health Relevance. The number of cancer survivors is steadily increasing; for example, in 2019 an estimated 16.9 million individuals in the United States alone were considered cancer survivors. With this positive upward trend in survivorship, the long-term lung toxicity of radiation therapy gains importance. To address this critical need, we propose a simple, sensitive, and low-dose imaging tool that utilizes a single x-ray projection to detect the early onset of radiation- induced lung fibrosis.

PI_NAMEs: NOËL, PETER B (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Affect;Alveolus;Animal Experimentation;Animal Experiments;Animal Model;Animals;Architecture;Area;attenuation;Biological;Cancer Survivor;Clinical;Clinical Research;contrast imaging;cost;Darkness;Data;Dedications;deep learning;design;detector;diagnostic accuracy;diagnostic tool;Diagnostic X-Ray;Disease;Dose;Early Diagnosis;early onset;Electromagnetic Energy;Equipment;Evaluation;expiration;Gases;Goals;Image;imaging detection;Imaging Device;improved;in vivo;in vivo evaluation;Individual;Interferometry;Investments;Laboratory Research;longitudinal animal study;Lung;Lung Diseases;Membrane;metallicity;Methods;microCT;Modeling;Monitor;Mus;nanoparticle;novel;Optics;Outcome;Paper;particle;Pattern;Performance;Phase;Photons;Physics;portability;pre-clinical;preclinical evaluation;preclinical imaging;preclinical study;prospective;Proton Radiation;proton therapy;prototype;public health relevance;Pulmonary alveolar structure;Pulmonary Fibrosis;Radiation;Radiation Dose Unit;Radiation exposure;Radiation therapy;Radiation Toxicity;Research;research facility;Resolution;Roentgen Rays;Shapes;Shock;side effect;Signal Transduction;Site;software infrastructure;Source;Structure;survivorship;Synchrotrons;System;targeted treatment;Techniques;tool;Toxic effect;Translating;Translations;transmission process;Treatment outcome;Treatment-related toxicity;trend;United States;X-Ray Medical Imaging

PROJECT_TITLE: Speckle x-ray imaging: detecting early changes in lung microstructure

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Human Genome;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Pediatric high-grade gliomas (pHGGs) are one of the most common and aggressive forms of brain cancer, with a median survival of 9-15 months. We aim to study a subtype of pHGG which harbors H3.3-G34R, ATRX and TP53 inactivating mutations. Our goal is to assess the molecular mechanisms by which H3.3-G34R impacts the biology of pHGGs, influence the tumor immune microenvironment and the response to therapeutics, including immune-mediated mechanisms.

PI_NAMEs: CASTRO, MARIA G (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;ATAC-seq;ATRX gene;Biology;Blood - brain barrier anatomy;Brain;brain parenchyma;Cause of Death;CD8-Positive T-Lymphocytes;Cell Cycle Checkpoint;Cell Reprogramming;Cells;Cerebral hemisphere;chemotherapy;Chemotherapy and/or radiation;Childhood;Childhood Brain Neoplasm;Childhood Glioma;Chromatin;Chromatin Structure;Combined Modality Therapy;cytokine;Data;Defect;Development;DNA Damage;DNA Repair;DNA Repair Disorder;Epigenetic Process;Excision;Exhibits;experimental study;Frequencies;Gene Expression Regulation;gene repression;Gene set enrichment analysis;Genes;Genetic;Genetic Engineering;genetic makeup;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Glioma;Goals;Histologic;Histones;homologous recombination;Human;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunity;Immunocompetent;Immunologic Memory;immunoregulation;Impairment;In Vitro;in vivo;Infiltration;inhibitor;Innate Immune System;Interferon Type I;Intracranial Neoplasms;Investigation;Ionizing radiation;knock-down;Lesion;Link;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Mediating;Modality;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Myeloid-derived suppressor cells;Nature;nerve stem cell;Nonhomologous DNA End Joining;novel therapeutic intervention;Ontology;Pathogenesis;Pathway interactions;permissiveness;pharmacologic;Phenotype;Play;Preclinical Testing;Process;Production;Radiation therapy;Recurrent tumor;Relaxation;repaired;Resistance;resistance mechanism;response;Role;Shapes;single-cell RNA sequencing;Sleeping Beauty;standard of care;Stimulator of Interferon Genes;System;Testing;Therapeutic;therapy outcome;therapy resistant;TP53 gene;transcriptome sequencing;Transposase;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Up-Regulation;Variant;young adult

PROJECT_TITLE: Uncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma.

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE A substantial barrier to improved treatment for sepsis is lack of in-depth knowledge of endogenous factors that modulate production of the cytokines that drive morbidity and mortality. We have identified mammalian IRGM proteins as novel inhibitors of inflammatory cytokine production. This proposal will define the mechanisms through which these proteins protect against sepsis-induced inflammation and sepsis-related mortality, enabling the development of novel therapeutics and/or diagnostics.

PI_NAMEs: COERS, JOERN ;TAYLOR, GREGORY A (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Affect;Ankylosing spondylitis;antimicrobial;Autophagocytosis;Bacteria;Binding;Binding Proteins;CASP4 gene;Cell Line;Cells;clinically relevant;Collection;Crohn's disease;cytokine;Cytoplasm;Data;Development;Disease;Dynamin;Endogenous Factors;Endosomes;Etiology;Event;Excision;extracellular;gastrointestinal;gene therapy;Genes;glucose metabolism;Goals;Golgi Apparatus;Guanosine Triphosphate Phosphohydrolases;Host Defense;Human;human model;Immune;Immune response;Immune System Diseases;Immunity;immunoregulation;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;Ingestion;inhibitor;Interferons;Intestinal Perforation;Intracellular Membranes;Knock-out;Knockout Mice;Knowledge;Lead;Link;Macrophage;Mediating;Membrane;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Microbe;Mitochondria;Modeling;Molecular;molecular diagnostics;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;non-alcoholic fatty liver disease;novel;novel diagnostics;novel therapeutics;Outcome;pathogen;pathogenic bacteria;Pathway interactions;pharmacologic;polymicrobial sepsis;Predisposition;Process;Production;protein function;Protein Isoforms;Proteins;Publishing;Regulation;Resistance;response;RNA Splicing;Role;sensor;Sepsis;septic patients;Series;Shapes;Signal Pathway;Signal Transduction;System;Testing;TLR4 gene;trafficking;translational impact;Tuberculosis;uptake;Variant;Work

PROJECT_TITLE: IRGM proteins as regulators of inflammation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Patient enrollment is a key determinant of the success of National Cancer Institute (NCI)-sponsored clinical trials. Clinician scientist, Stephen Chun, M.D. at The University of Texas, M.D. Anderson Cancer (MDACC), established the NCI-sponsored radiation clinical trial program in MDACC’s Houston Area Location (HAL) integrated academic satellite campuses which has led to unprecedented increases in enrollments from economically and ethnically diverse populations. With the NCI cooperative groups, Dr. Chun serves in leadership roles that support trial analysis, concept development, and patient enrollment, and this NCI R50 funding mechanism will enable Dr. Chun to expand NCI-sponsored enrollments in the MDACC HALs and his leadership efforts with the NCI cooperative groups.

PI_NAMEs: CHUN, STEPHEN G (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Address;Area;Artificial Intelligence;Biological Markers;Calendar;Cancer Center;career;Clinical Research;Clinical Trials;continuing medical education;demographic disparity;Development;Doctor of Medicine;Educational workshop;Eligibility Determination;Enrollment;ethnic diversity;Exclusion Criteria;Faculty;Funding;Funding Mechanisms;health care disparity;inclusion criteria;Institution;Leadership;Location;Malignant neoplasm of central nervous system;Malignant Neoplasms;Minority Enrollment;Mission;National Cancer Institute;neurocognitive test;Oncology;oncology trial;participant enrollment;Patients;Population Heterogeneity;Principal Investigator;programs;Protocols documentation;Radiation;Radiation Oncology;Radiation Therapy Oncology Group;Research;Research Personnel;Role;Scientist;Services;success;Texas;Underrepresented Minority;Universities;Woman

PROJECT_TITLE: A radiation oncology clinician scientist devoted to building an inclusive clinical research program in an integrated academic satellite network in service to the National Cancer Institute


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Depression;Diabetes;Mental Health;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: LUBBOCK

ORG_DEPT: NUTRITION

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: Project Narrative The purpose of our study is to investigate mitochondrial dysfunction modulated by neurotransmitter serotonin and protective role of SSRI in depression, diabetes, and dementia (3Ds). Our study will be conducted using three transgenic mouse models and three cell models representing 3Ds pathology and representing 3 major brain areas. The outcomes of this research will provide information on whether citalopram confers protective effects comorbid effect on depression, diabetes and dementia.

PI_NAMEs: HEGDE, VIJAY KARKAL (contact);SHIN, ANDREW CHANGHUN

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Age Months;Aging;Alzheimer's Disease;Alzheimer's disease patient;Area;Autophagocytosis;Behavioral Symptoms;Biogenesis;Biological;Brain;Brain Stem;Cardiovascular Diseases;Cause of Death;Cell model;Cells;cellular resilience;Central Nervous System;Cessation of life;Chronic;Chronic Disease;Circadian Rhythms;Citalopram;Clinical;comorbid depression;comorbidity;Complementary DNA;Complex;Data;Defect;Dementia;dementia risk;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Disease Progression;Dorsal;Dose;Drug Prescriptions;Energy Metabolism;experimental study;Exposure to;Functional disorder;Genetic Transcription;Glucose;Goals;Hippocampus;Histones;Homeostasis;Hyperglycemia;Hypothalamic structure;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;insight;Insulin Resistance;Link;Mental Depression;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;mutant;Nerve Degeneration;Nervous System Physiology;neurogenesis;Neurons;neuroprotection;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Outcomes Research;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Peripheral Nervous System;Physiological;Play;Population;Preventive;Process;protective effect;Qualifying;Reporting;Research;Research Design;Research Personnel;Research Subjects;resilience;Risk Factors;Rodent;Role;Selective Serotonin Reuptake Inhibitor;Serotonin;Synapses;Synaptic Transmission;tau mutation;tau Proteins;Testing;Time;Tissues;TPH2;Transfection;Transgenic Mice;Transgenic Model;treatment response

PROJECT_TITLE: Serotonin modulated mitochondrial dysfunction in Depression Diabetes and Dementia (3Ds)

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Dilated cardiomyopathy (DCM) is a leading cause of heart failure and death, and there is an urgent need to identify new molecular targets that could lead to the development of more effective treatment strategies. Our research is focused on a protein called ATF4, which acts as a switch that turns on genes essential for cardiac muscle function. By studying how ATF4 works, we hope to understand how mutations case DCM and identify new ways to treat patients.

PI_NAMEs: KARAKIKES, IOANNIS  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: activating transcription factor 4;ATF2 gene;BAG3 gene;Binding;biological adaptation to stress;Biological Assay;Carbon;Cardiac;Cardiac Myocytes;cardioprotection;Caring;Cellular Stress;Cessation of life;chromatin immunoprecipitation;clinically relevant;cohort;Complex;Coupled;CRISPR/Cas technology;Data;Dependovirus;Development;Dilatation - action;Dilated Cardiomyopathy;Disease;Echocardiography;effective therapy;familial dilated cardiomyopathy;Functional disorder;functional genomics;Gene Delivery;Gene Expression;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Heterogeneity;Genetic Predisposition to Disease;Genetic Transcription;Goals;Heart;Heart Diseases;Heart failure;heart function;high throughput screening;Human;improved;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;interdisciplinary approach;Knock-in;Knock-in Mouse;Mediating;Metabolism;Modeling;molecular phenotype;Molecular Target;mouse model;Mus;Muscle function;Mutation;Myocardium;new therapeutic target;novel;Ontology;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;PF4 Gene;Phenocopy;Phenotype;Physiology;Population;precision medicine;Prevalence;Privatization;promoter;protein expression;Proteins;Publishing;Regulation;Research;response;Role;Safety;Sarcomeres;Sarcoplasmic Reticulum;Signal Transduction;Stress;Structure;targeted treatment;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;transcription factor;Translating;treatment strategy;Up-Regulation;Work

PROJECT_TITLE: Unraveling the pathogenesis of familial dilated cardiomyopathy towards precision medicine

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Rare Diseases

PHR: Narrative  Energy metabolism is central to virtually all cells in the body, and metabolic reprogramming, a fundamental alteration of tissue metabolism supporting the rapid growth of cancer cells, is particularly pronounced in glioma and other brain tumors. From a therapeutic perspective, this alteration of normal processes provides an opportunity for highly novel therapies which aim to reverse these abnormal metabolic processes is the goal. This projects seeks to develop an innovative approach for the non-invasive imaging of brain tumor metabolism using MRI of deuterated glucose in order to provide a powerful new tool for improved diagnostics, therapy planning, and assessment of treatment response.

PI_NAMEs: SPIELMAN, DANIEL M (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Affect;Anatomy;Brain;Brain Neoplasms;Brain scan;brain tumor imaging;Cancer Cell Growth;Cells;Central Nervous System;Clinical;clinical translation;Coin;Consumption;convolutional neural network;Data;data acquisition;Data Set;Detection;Deuterium;Development;Diagnostic;Energy Metabolism;Exhibits;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Gases;Glioblastoma;Glioma;Glucose;glucose metabolism;glucose uptake;Glycolysis;Goals;Half-Life;Human;Image;image processing;imaging approach;Imaging Device;imaging study;Imaging Techniques;improved;in vivo;in vivo imaging;Inhalation;innovation;Joint repair;Label;Lesion;Machine Learning;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Measurement;Measures;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;Methods;multimodality;Noise;non-invasive imaging;Normal tissue morphology;novel;novel therapeutic intervention;novel therapeutics;Oxidative Phosphorylation;Oxygen Consumption;Patients;Performance;Phenotype;Pilot Projects;Play;Positron-Emission Tomography;Process;Production;Protocols documentation;Pyruvate;Radioactive;rapid growth;reconstruction;Reporting;Resolution;Role;Scanning;signal processing;Signal Transduction;simulation;Sum;System;Techniques;Testing;Therapeutic;timeline;Tissues;tool;Training;treatment response;tumor;tumor growth;Tumor Markers;tumor metabolism;virtual;Warburg Effect

PROJECT_TITLE: Enhanced Deuterium Metabolic Imaging (DMI) of Metabolic Reprogramming in Brain Tumors

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative We expect that this study will provide a prototype of a technology-based physical activity promotion program to reduce depressive symptoms among midlife racial/ethnic minorities. This study will subsequently accelerate the translation of technology-based programs into primary care settings. Ultimately, this study will contribute to reducing racial/ethnic disparities in health/disease experience by providing directions for culturally competent health care services.

PI_NAMEs: CHEE, WONSHIK ;IM, EUN-OK  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acceleration;active control group;Adopted;Adoption;Age;aging population;American;Asian Americans;Attitude;Behavioral;Body mass index;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Characteristics;Computer software;Computers;Control Groups;Cost Analysis;COVID-19 outbreak;COVID-19 pandemic;Cultural Characteristics;cultural competence;depressive symptoms;design;Devices;Dimensions;Disease;efficacy evaluation;epidemiology study;ethnic health disparity;ethnic minority;Ethnic Minority Women;Ethnic Population;European;experience;Family history of;fitbit;follow-up;Gender;Generations;Genetic;Goals;group intervention;Guidelines;handheld mobile device;Health;health care service;Health Personnel;Health Status;Heart Rate;Household;Immigration;improved;innovation;Internet;intervention effect;Intervention Studies;Korean American;Koreans;Leisures;Life;Life Style;Maintenance;Measures;Mediating;men;Menopausal Status;Mental Depression;Mental disorders;Mental Health Services;middle age;Midlife women;Modality;Moods;Operating System;Outcome;Patient Self-Report;perceived discrimination;Pharmacotherapy;Physical activity;pilot test;Population;preference;Prevalence;primary care setting;Program Effectiveness;programs;prototype;Psychotherapy;racial disparity;racial minority;racial minority women;racial population;Randomized;Recommendation;recruit;Research;Rest;Risk;Running;social media;social stigma;Social support;Stress;Stress and Coping;stress reduction;Surface;Symptoms;Technology;technology intervention;Testing;theories;Time;Translations;Transportation;waist circumference;web app;web server;web site;Woman;Work

PROJECT_TITLE: A Web-App Based Lifestyle Physical Activity Promotion Program to Improve Depressive Symptom Experience: Midlife Korean American Women

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Dietary Supplements;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Inflammatory bowel disease is a chronic illness that represents a significant public health and economic burden, and there is an urgent need to improve our understanding of modulators of intestinal inflammation in order to identify novel therapeutic targets. Based on our recent findings that specific diet-induced microbial metabolites trigger pathologic activation of the group 2 innate lymphoid cells (ILC2s) and associated type 2 inflammation, the focus of this proposal is to dissect the role of this diet-microbiota axis in the regulation of intestinal inflammation.

PI_NAMEs: ARTIS, DAVID  (contact);GUO, CHUN-JUN

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Address;Adoptive Cell Transfers;Affect;Antiinflammatory Effect;associated symptom;Bacteria;Bacteroidetes;Bile Acids;Biological;Blood Circulation;Brain;Cells;Cholic Acids;Chronic Disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colonic inflammation;comparative;Complex;Consumption;cost;CRISPR/Cas technology;Crohn's disease;cytokine;Data;Development;Diet;dietary;Dietary Component;Dietary Fiber;Disease;Distant;Economic Burden;Endocrine Glands;Environmental Risk Factor;eosinophil;Eosinophilia;Etiology;Fermentation;Fiber;Flare;Food;Frequencies;Gene Deletion;Gene Expression;Gene Expression Profiling;gene-editing approach;Genetic;Genetic Engineering;genetic manipulation;Germ-Free;gut inflammation;Human;human disease;Immune;Immune response;Immunologic Factors;Immunologics;immunoregulation;improved;In Vitro;in vivo;Individual;Indoles;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-5;Intestines;Inulin;Libraries;liver inflammation;Lymphoid Cell;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Metabolic;Metabolic Pathway;metabolomics;microbial;microbiota;microbiota metabolites;mouse model;Mus;mutant;new therapeutic target;novel;novel therapeutics;Opportunistic Infections;Outcome;Output;Pancreatitis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pre-clinical;prevent;Production;Propionic Acids;Public Health;receptor;receptor expression;Recommendation;Regulation;repaired;response;Risk;Role;Sampling;Serum;Severity of illness;Site;Source;Stromal Cells;Symptoms;Testing;Tissues;transcriptional reprogramming;transcriptomics;Translating;Ulcerative Colitis;United States;Volatile Fatty Acids

PROJECT_TITLE: Dietary Regulation of Intestinal Inflammation and Repair

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Salt sensitivity of blood pressure, with or without hypertension, is associated with increased cardiovascular risk and overall mortality; reduction in NaCl consumption is a treatment of salt sensitivity. However, decreasing salt intake in some may actually increase the increased risk for hypertension, and cardiovascular and renal diseases and death. Identifying genes that cause salt sensitivity and, in this proposal, inverse salt sensitivity would be a step towards precision medicine.

PI_NAMEs: JOSE, PEDRO A. (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Accounting;Adrenergic Receptor;Affect;Age;Aldosterone;Amish;Angiotensins;Animal Model;Blood Pressure;blood pressure elevation;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Catecholamines;Cells;Cessation of life;Chinese population;Chronic Kidney Failure;Collection;comorbidity;Consumption;Data Set;Diabetes Mellitus;Diastolic blood pressure;Diet;Dietary Assessment;Dopamine;Dopamine D2 Receptor;Double-Blind Method;End stage renal failure;Epigenetic Process;Essential Hypertension;Etiology;Excretory function;Failure;Gene Expression;Genes;Genetic;genetic variant;Germ Lines;Human;human old age (65+);Hypertension;hypertension treatment;hypertensive;Impairment;Incidence;Individual;Inflammation;inflammatory marker;Injury to Kidney;Insulin Resistance;Intake;Kidney;Kidney Diseases;kidney dysfunction;kidney fibrosis;Lipids;Lipoproteins;Mediating;mortality;Mus;National Health and Nutrition Examination Survey;Non obese;normotensive;NR4A2 gene;obese person;Patients;Plasma;Population;precision medicine;Predisposition;premature;pressure;Prevalence;prevent;Proximal Kidney Tubules;Randomized;receptor;receptor expression;receptor function;Receptor Gene;Receptor Inhibition;Receptor, Angiotensin, Type 1;Recommendation;Renal function;Renal tubule structure;Renin;Renin-Angiotensin System;Research;Reservations;Resistance;Risk;Role;salt intake;salt sensitive;selective expression;Sodium Chloride;Sprague-Dawley Rats;Surveys;Sympathetic Nervous System;Testing;transcription factor;urinary;Urine;Variant;Vascular Diseases

PROJECT_TITLE: D2 receptor variation and renal dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_NAME: POSIT SCIENCE CORPORATION

PHR: Project Narrative The goal of this project is to evaluate the long-term efficacy of a Plasticity-based Adaptive Cognitive Remediation program (PACR-CT v.2.0) for the prevention of Alzheimer’s disease (AD). This proposal aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized & web-deliverable training program suite five years from the initial 10 weeks of training and test the interactive effect of previous training and 10 weeks of booster training. These outcomes will provide deeper understanding of the neurobehavioral status of a study population 5-years after the initial 10 weeks of program completion and of the benefit of the booster training and its interaction with prior-training. Based on the results of our study, the optimal training schedule to sustain and potentially further-grow program-delivered benefits will be implemented.

PI_NAMEs: LEE, HYUN KYU  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: active control;Adult;Age;age effect;Age-associated memory impairment;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Assessment tool;blood-based biomarker;Brain;brain health;brain volume;Chronology;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cognitive rehabilitation;Cognitive remediation;cognitive testing;cognitive training;Collaborations;commercialization;comparative efficacy;computerized;Conduct Clinical Trials;Dementia;design;Development;Devices;Economic Burden;Effectiveness;efficacy evaluation;Enrollment;Epidemiology;Evaluation;evidence base;follow up assessment;follow-up;Follow-Up Studies;Functional Magnetic Resonance Imaging;Goals;Home;Hour;Impaired cognition;improved;Individual;information processing;Internet;Interval training;Iowa;life span;Longevity;Maintenance;Measures;Mediating;Modeling;Monitor;Nerve Degeneration;Nervous System Physiology;neurobehavioral;Neuronal Plasticity;novel;older adult;Outcome;Participant;Pathology;Performance;Pharmacotherapy;Phase;phase I trial;Phase II Clinical Trials;phase II trial;Play;Population;Prevention;processing speed;programs;Randomized;recruit;resilience;Schedule;social;Source;Standardization;Structure;study population;Testing;Texas;Therapeutic;Time;tool;Training;Training Programs;Universities;white matter

PROJECT_TITLE: Phase IIB Plasticity-based Adaptive Cognitive Remediation for Alzheimers Disease


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The sodium-dependent citrate transporter NaCT plays a key role in fatty acid biosynthesis. In this multi-PI R01, we will combine structural (cryo-EM), dynamic (single molecule FRET and molecular dynamics simulations) and kinetic (transport and binding assays) techniques to understand the transport mechanism of NaCT and its bacterial homolog VcINDY. The information obtained will help in understanding the molecular pathogenesis of various metabolic diseases such as diabetes, obesity and cancer, and may aid in the development of potential treatments.

PI_NAMEs: GONZALEZ, RUBEN L;TAJKHORSHID, EMAD ;WANG, DANENG  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Anions;Bacteria;Binding;Binding Sites;Biochemical;Biological Assay;Caloric Restriction;carboxylate;Cell membrane;Charge;citrate carrier;Citrates;Compensation;Computer Models;Coupled;Coupling;Cryoelectron Microscopy;Cytoplasm;Data;design;Development;Diabetes Mellitus;dicarboxylate-binding protein;driving force;drug development;Drug Industry;Elevator;Energy-Generating Resources;Event;experimental study;extracellular;Family;Family member;fatty acid biosynthesis;Fatty acid glycerol esters;Fatty Acids;Fluorescence Resonance Energy Transfer;fly;Free Energy;Glycolysis;Homologous Gene;Human;improved;Individual;Industry;inhibitor;Insulin Resistance;Ions;Kinetics;Knockout Mice;LDL Cholesterol Lipoproteins;Lipids;Liposomes;Malignant Neoplasms;Measurement;Measures;member;Membrane;Membrane Transport Proteins;Metabolic;Metabolic Diseases;Methods;Molecular;Molecular Conformation;molecular dynamics;Mutation;nanodisk;Nature;Obesity;oxidation;Pathogenesis;Pathway interactions;Play;Positioning Attribute;Productivity;protein transport;Proteins;proteoliposomes;prototype;Reaction;Role;Sampling;sensor;Sequence Homology;Series;Side;single-molecule FRET;Site;small molecule inhibitor;Sodium;sodium ion;Specificity;stoichiometry;structural determinants;Structure;Succinates;symporter;Techniques;Testing;therapeutic target;Time;Work

PROJECT_TITLE: Dynamics and mechanism of sodium-dependent carboxylate transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Narrative In the kidney, NaCl transport depends in part on the renal transporter NKCC2, an apical Na+/K+/2Cl- co- transporter the thick ascending limb (TAL) of the loop of Henle. The molecular mechanisms that control apical membrane NKCC2 levels involve endocytosis, recycling and exocytic insertion. We found 2 proteins (ALMS1 and ACTN4), that cause human diseases associated with kidney damage, high blood pressure and abnormal renal physiology, that interact with NKCC2. We will study the biological mechanisms by which ALMS1 and ACTN4 maintain normal renal function and NaCl transport, and how dysfunction occurs when they are absent.

PI_NAMEs: ORTIZ, PABLO A. (contact)

PROJECT_TERMS: absorption;Acetazolamide;Affect;alpha Actinin;Alstrom syndrome;Animal Model;Apical;apical membrane;benzamil;Binding;Biological;Biology;Biotinylation;Blood Pressure;blood pressure regulation;Bumetanide;Carrier Proteins;Cells;Complex;Data;Distal;Duct (organ) structure;Endocytosis;epithelial Na+ channel;Epithelium;Excretory function;Feedback;Focal and Segmental Glomerulosclerosis;Functional disorder;Gene Deletion;Genes;Genetic;Goals;Homeostasis;Human;human disease;human model;Hypertension;Image;Ions;Kidney;Kidney Diseases;Knock-out;Limb structure;Macula densa;Mass Spectrum Analysis;Measures;Mediating;Membrane;Microscopy;Molecular;Monitor;Mutation;Natriuresis;Nephrons;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;patch clamp;Physiology;podocyte;prevent;protein protein interaction;Proteins;Proteomics;Rattus;Recycling;Regional Perfusion;Regulation;renal damage;Renal function;Retrieval;Role;salt balance;salt sensitive hypertension;Single Nucleotide Polymorphism;Sodium Chloride;Structure of ascending limb of Henle's loop;Surface;symporter;thiazide;Thick

PROJECT_TITLE: Regulation of NKCC2 and renal NaCl transport by protein-protein interactions


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE The federal agencies and professional organizations have mounted a significant effort to address an increasingly recognized public health problem, Early Childhood Caries (ECC), among the underserved population. A better understanding of the biological factors related to this pediatric oral health disparity is urgently needed.  Leveraging an archived underserved birth cohort, our multidisciplinary team proposes using cutting- edge metagenomic sequencing and analysis tool, combined with a high-dimensional statistical machine learning approach, to examine the early-life oral microbiome development and identify its multilevel determinant and association to ECC. ECC risk factors revealed via prediction models could be used as targets for ECC early prediction and prevention specifically suitable for underserved racial minority children.

PI_NAMEs: GILL, STEVEN R.;WU, TONGTONG ;XIAO, JIN  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Advisory Committees;Affect;African American;Archives;Bacteria;Biological;Biological Factors;Biometry;Birth;Black race;Caries prevention;Child;Child Development;Childhood;Chronic;cohort;Collection;Communicable Diseases;Communities;Computer Models;craniofacial;Data;data platform;Data Sources;Dental;Dental caries;Development;Disadvantaged minority;Discipline;Disease;Disparity;early childhood;early onset;Ensure;Environment;Environmental Risk Factor;ethnic minority;ethnic minority population;Exposure to;fungus;Genes;Genetic;Goals;Health;Health Disparities Research;health disparity;health record;high dimensionality;Human;Immune;Immunologic Factors;Immunologic Markers;infancy;Infant;Infant Development;innovation;Life;Life Cycle Stages;Low income;Machine Learning;machine learning prediction;Medical;metagenomic sequencing;Metagenomics;Methods;microbial;microbiome;microbiome composition;microbiota;Minority;minority children;Modeling;Mothers;multidisciplinary;Mycoses;National Institute of Dental and Craniofacial Research;Oral;oral bacteria;Oral health;oral microbial community;oral microbiome;Pattern;Perinatal;predictive modeling;prenatal;Preschool Child;Prevention;Professional Organizations;Public Health;Race;racial disparity;racial minority;racial minority population;racial population;Research Personnel;Risk Factors;Saliva;Salivary;Sampling;Severities;Shapes;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;statistical and machine learning;Streptococcus mutans;success;Testing;Time;tool;Training;transmission process;Underserved Population;Work

PROJECT_TITLE: Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Obesity and obesity-related diseases have become one of the greatest threats to human health and a tremendous financial burden for individuals and societies. NLRP3 inflammasome-mediated inflammation in obesity has been recognized to promote the occurrence and progression of obesity-related diseases. The proposed research is of great health relevance because it will pave the way for translating dietary exosome-like nanoparticles and their active biomolecules into an intervention to curb inflammation in obesity.

PI_NAMEs: YU, JIUJIU  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Allium schoenoprasum;Anti-Inflammatory Agents;Biological Availability;Cause of Death;Cells;chemical reduction;Chemical Structure;Chemicals;Chronic;clinical practice;combat;Complex;Development;Diet;diet-induced obesity;dietary;Dietary Fats;Disease;Disease Progression;Dose;Edible Plants;exosome;feeding;Financial Hardship;Fruit;Gene Expression;gene function;Goals;Health;Heart Diseases;High Fat Diet;Human;improved;Individual;Inflammasome;Inflammation;inhibitor;Innate Immune System;innovation;Intervention;Lipids;lipophilicity;Macrophage;Manuscripts;Mediating;Membrane;Metabolic;Milk;Modality;Mus;nanocarrier;nanoparticle;Non-Insulin-Dependent Diabetes Mellitus;Nutraceutical;Obesity;Obesity associated disease;Oral;Oral Administration;Outcomes Research;particle;Patients;Persons;Phosphorylcholine;Pilot Projects;prevent;Progressive Disease;Proteins;Research;Risk;RNA;Role;sensor;Societies;Stroke;Testing;Therapeutic;Therapeutic Effect;Tissues;Translating;translational applications;translational potential;Translations;United States;Vegetables;Work

PROJECT_TITLE: Role of chive-derived exosome-like nanoparticles in suppressing inflammation in obesity

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: NEWARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative: Trauma and bacterial infections often necessitate extirpation of dental pulp. Regenerating the soft vascularized tissue in the canal is a major unmet clinical goal. We’ll develop a peptide hydrogel formulation that promotes vascularized soft tissue after pulpectomy, with low risk of bacterial colonization.

PI_NAMEs: KUMAR, VIVEK  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adolescent;Adoption;Adult;American;Amino Acids;amphiphilicity;angiogenesis;Animals;antimicrobial;Antimicrobial Effect;Apical;Applications Grants;Architecture;arteriole;Bacteria;Bacterial Infections;Binding;Biodegradation;Biological;Biological Assay;biomaterial compatibility;Biomedical Engineering;Biomimetics;biophysical analysis;biophysical properties;Blood Vessels;canine model;Canis familiaris;Cell Membrane Permeability;Cells;Cellular Infiltrate;Circulation;Clinical;Coculture Techniques;combinatorial;Complex;cone-beam computed tomography;Cues;Cuspid;Data;Dental;Dental caries;Dental Pulp;Dental Pulp Necrosis;Dentin;Deposition;Effectiveness;efficacy evaluation;Endodontics;Endothelial Cells;Endothelial Growth Factors Receptor;Enzyme-Linked Immunosorbent Assay;Evaluation;Evolution;Excision;Exhibits;experimental study;Exposure to;Extracellular Matrix;Flow Cytometry;Formulation;Future;Gel;Goals;Growth;Growth Factor;Hindlimb;Histologic;Hydrogels;implant material;implantation;improved;In Vitro;in vivo;in vivo regeneration;Infection;Infection prevention;Infiltration;Inflammation;Injectable;Injury;instrument;instrumentation;Ischemia;KDR gene;Kinetics;Learning;Mammalian Cell;Mechanics;Membrane;meter;Microbe;Microbial Biofilms;mimetics;mineralization;Modality;Modeling;Modification;multidisciplinary;nanofiber;Natural regeneration;Nerve;Neurons;Nonvital Tooth;Odontoblasts;Oral;oral bacteria;oral biology;oral pathogen;Outcome;Pain;Patients;PECAM1 gene;Peptide Signal Sequences;Peptides;periapical;Peripheral;permanent tooth;Permeability;Phosphorylation;Physiologic Ossification;Positron-Emission Tomography;preclinical efficacy;preservation;prevent;Procedures;Proliferating;Property;Publishing;Pulp Canals;Pulpectomy;radiological imaging;receptor;Recurrence;regenerative;Regenerative research;Reporting;Research Personnel;Research Project Grants;Rest;Risk;Rodent;Rodent Model;Safety;self assembly;Signal Transduction;single photon emission computed tomography;soft tissue;Source;Specialist;Structure;success;Surface Plasmon Resonance;Techniques;Testing;Time;tissue regeneration;Tissues;tongue papilla;Tooth structure;transcriptome sequencing;Translating;Trauma;Variant;Vascular Endothelial Growth Factors;Vascularization;venule;Vertebral column

PROJECT_TITLE: Angiogenic and anti-microbial supports for pulp regeneration


ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative. The goal of this project is to develop a new image-correlated genomic technology that will improve the detection and characterization of genetic disease susceptibility, response to environmental factors, and help develop potential treatment regimens that arise based on knowledge gained from use of the technology. The method combines high resolution optical microscopy with DNA sequencing to allow researchers to obtain specific DNA sequence information from targeted nuclear regions in user-selected cells in the population under study. The technology will offer new insights into how genes are regulated by the environment and how the cell’s nucleus structurally reconfigures itself in response.

PI_NAMEs: ZIPFEL, WARREN R (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Architecture;Biological;Biological Assay;Biotin;Biotinylation;Cell Differentiation process;Cell Line;Cell Nucleus;Cells;cellular imaging;Cellular Stress;Chromatin;chromosome conformation capture;Collection;Computer software;Computers and Advanced Instrumentation;Consumption;crosslink;Custom;Cytosol;Data;Dedications;design;design and construction;Detection;Disease;Disease susceptibility;DNA;DNA Sequence;DNA sequencing;Enhancers;Ensure;Environment;Environmental Risk Factor;Eukaryota;Experimental Designs;experimental study;flexibility;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Regulation;gene function;Gene Silencing;Genes;Genetic Diseases;Genome;genome-wide;genomic locus;Genomic Segment;genomic tools;Genomics;Goals;Hand;Image;Image Analysis;image processing;imaging modality;improved;In Situ;Individual;insight;instrument;interest;Knowledge;Label;Lasers;Libraries;Machine Learning;Manuals;Measures;Methods;Microfluidic Microchips;Microfluidics;Microscope;Microscopic;Microscopy;Molecular Conformation;multi-photon;new technology;novel;Nuclear;Nuclear Structure;Optics;Physiologic pulse;Population;Population Analysis;Preparation;Procedures;Process;promoter;Protocols documentation;real-time images;Regulation;Reporting;Research Personnel;Resolution;response;Role;sample fixation;Sampling;Scanning;Series;Shapes;Signal Transduction;Site;software development;Stem Cell Research;Structure;Structure/Function Nuclei;System;Technology;technology research and development;three dimensional structure;Time;Transgenes;Treatment Protocols;Tube;two-photon;Validation

PROJECT_TITLE: Femto-seq: Targeted photo-biotinylation, pulldown and sequencing of locus and region-specific DNA from femtoliter volumes within individual cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Infectious Diseases;Lung;Patient Safety;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Community-acquired pneumonia is the most common serious pediatric infection and a leading cause of hospitalization for children in the United States, yet wide variation in care and limitations of current management approaches suggest that evidence-based tools are necessary to improve clinical decision- making. This proposal will improve health outcomes for children with pneumonia by developing and broadly validating a risk prediction rule that will make care safer and more effective by minimizing hospitalization and resource use in children who are at low risk of severe disease, while targeting more intensive management to those at higher risk to prevent progression to severe outcomes. Thus, the proposed research is relevant to the strategic objectives of NHLBI to develop novel diagnostic and therapeutic strategies to prevent, treat, and cure lung diseases and to optimize clinical and implementation research to improve health and reduce disease.

PI_NAMEs: FLORIN, TODD ADAM (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: 18 year old;Accident and Emergency department;Address;Adult;adverse outcome;Antibiotics;Anxiety;Applied Research;Area;Atelectasis;Attention;Behavior;Binding;Biological Markers;biomarker selection;Biometry;Blood capillaries;Blood Pressure;C-reactive protein;Calibration;Caring;Chest;Child;Child Care;Childhood;Clinical;clinical decision-making;Clinical Research;clinical risk;cohort;Communicable Diseases;community acquired pneumonia;Complement;Confidence Intervals;cost;Decision Making;Derivation procedure;Deterioration;Development;Diagnostic tests;Disease;Disease Progression;Early Intervention;Emergency Care;Emergency research;Enrollment;Ensure;Epidemiology;Evaluation;evidence base;experience;Goals;Guidelines;Health;high risk;Hospitalization;hospitalization rates;Hospitalized Child;Hospitals;Hour;implementation research;improved;Infection;Infrastructure;innovation;Inpatients;Institution;Intervention;Judgment;Knowledge;Lung Diseases;Machine Learning;Medical;Medical Errors;Medicine;Mentored Patient-Oriented Research Career Development Award;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Nosocomial Infections;novel;novel diagnostics;novel therapeutic intervention;Observational Study;Outcome;Outpatients;Patients;pediatric emergency;Pediatric Hospitals;Performance;personalized approach;Phase;Pleural effusion disorder;Pneumonia;Pneumonia Severity Index;predictive modeling;predictive tools;prevent;procalcitonin;prognostic tool;prognostication;prospective;Prospective, cohort study;Provider;Recommendation;Research;Resources;respiratory;Risk;Risk Estimate;Risk Factors;risk prediction;risk stratification;ROC Curve;Schools;Severities;Severity of illness;Societies;Standardization;success;Targeted Research;Testing;Thoracic Radiography;Time;tool;United States;Validation;Variant;viral detection;virus testing;Work

PROJECT_TITLE: Derivation and Validation of the Pediatric Community-Acquired Pneumonia Severity (PedCAPS) Score

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE The US health care system leads the world in administrative complexity and its associated costs. Cancer is a complex and often high-acuity condition with persistent disparities in health outcomes, making cancer care delivery a priority setting for assessing patient administrative burdens and identifying solutions. The proposed research uses qualitative, survey, and claims data in a sequential mixed methods analysis that will enable the measurement and diagnosis of administrative burden across cancer care settings and produce evidence identifying and motivating actionable organizational or policy targets for clinical leaders and policymakers.

PI_NAMEs: KYLE, MICHAEL ANNE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adherence;Antineoplastic Agents;Architecture;cancer care;cancer recurrence;cancer therapy;care coordination;care delivery;care outcomes;career development;Caregivers;Caring;Characteristics;chemotherapy;Clinical;Communities;Complex;Comprehensive Cancer Center;cost;Data;data repository;Dedications;design;Development;Diagnosis;Doctor of Philosophy;Education;Emergency department visit;Equity;Failure;Financial cost;Focus Groups;Future;Goals;Guidelines;Health;health disparity;Health Policy;Health Services Accessibility;Health system;Healthcare Systems;high risk;Hospitalization;improved;Inequity;informal caregiving;innovation;insight;Knowledge;Link;Low income;Malignant Neoplasms;Managed Care;marginalization;marginalized population;Measurement;Measures;medication compliance;Mentors;Methods;Modality;novel;Oncology;Oral;Outcome;outreach;patient engagement;Patients;Persons;Pharmacy facility;Phase;Policies;Policy Maker;Prevalence;Process;programs;Property;Proxy;Psychometrics;Quality of Care;Recommendation;recruit;Reporting;repository;Research;Research Personnel;Respondent;response;Role;Services;Site;Stress;success;Supportive care;Survey Methodology;Surveys;theories;Time;Training;Validation;Work

PROJECT_TITLE: Patient Administrative Burden in Cancer Care Delivery


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Only ~22% of the human protein coding genes have been found to have a phenotype‐causing variant, the molecular basis of at least 3,298 phenotypes is not known, and many more Mendelian phenotypes have not yet been described. These data together with the fact that the vast majority of the disease‐causing variants investigated up to now are single‐nucleotide variants in the coding region suggests that there is a long way to go if we are to identify the molecular basis of every Mendelian phenotype, the details of the phenotypes, and the origins of the associated phenotypic variability (Sobreira and Valle, 2016). Enhancing genomic and phenotypic data sharing including better partnership with the patients will be fundamental to the discovery of the disease genes, the understanding of the diseases' mechanisms and development of treatments; since, this project focused on genomic and phenotypic data sharing will have broadly beneficial consequences for genetics and medicine.

PI_NAMEs: SOBREIRA, NARA  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Affect;analysis pipeline;Bioinformatics;Code;Collaborations;Communities;Consent;Country;Data;Data Analyses;data integration;data sharing;Databases;Development;Disease;disease-causing mutation;DNA Sequence Analysis;Education;Educational workshop;Electronic Mail;exome sequencing;Family;Frequencies;gene discovery;Genes;Genetics and Medicine;Genome;genome sequencing;genomic data;Genomic medicine;Genomics;Genotype;Human;improved;Individual;insertion/deletion mutation;interest;Internet;Java;Learning Module;lectures;Link;Maps;member;Metadata;Methods;Mitochondrial DNA;model organism;Molecular;Notification;novel;online resource;Orthologous Gene;Patients;phenome;Phenotype;phenotypic data;programs;Proteins;public database;Publications;Pythons;Rare Diseases;Research Personnel;Resources;search engine;sharing platform;Single Nucleotide Polymorphism;Source Code;Stream;Students;therapy development;tool;tool development;user-friendly;Variant;Visualization;web-based tool;Work

PROJECT_TITLE: GeneMatcher, VariantMatcher and PhenoDB, implementation of new features and connections

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Hematology

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Limited evidence suggests that depression, anxiety and cognitive impairment often cluster in older adults with atrial fibrillation (i.e., psychiatric multimorbidity) and may have a multiplicative negative effect on health outcomes such as poorer oral anticoagulant medication adherence and health-related quality of life. This K01 project will explore: (1) the prevalence of specific dyad and triad combinations of psychiatric multimorbidity; (2) how psychiatric multimorbidity affects oral anticoagulant use and outcomes; and (3) factors that influence successful anticoagulation in patients with psychiatric multimorbidity. Understanding the impact of psychiatric multimorbidity on oral anticoagulant use and success and understanding factors that influence success will help identify useful targets for intervention to ultimately improve the health of atrial fibrillation patients with psychiatric multimorbidity.

PI_NAMEs: BAMGBADE, BENITA A (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adherence;Adult;Adverse event;Affect;Anticoagulant therapy;Anticoagulants;Anticoagulation;Anxiety;Atrial Fibrillation;Behavior;Behavioral;Cardiovascular Diseases;career;Caregivers;Chronic;Client satisfaction;Clinical;clinical care;Clinical Skills;Cohort Studies;Communities;comorbidity;Complex;Data;Data Analyses;Decision Making;design;Diabetes Mellitus;Diagnosis;Disease;Doctor of Pharmacy;Dose;Educational workshop;Elements;Eligibility Determination;Event;experience;Family;Focus Groups;Funding;Geriatric Assessment;Goals;Guidelines;Health;health difference;health related quality of life;Health system;Healthcare;Hemorrhage;high risk;Impaired cognition;improved;insight;Intervention;Knowledge;Literature;Medical;Medical Records;medication compliance;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Monitor;multiple chronic conditions;National Heart, Lung, and Blood Institute;older adult;Oral;Outcome;Participant;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Population;Populations at Risk;Prevalence;professor;programs;protective factors;Recommendation;Reporting;Research;Research Activity;Research Methodology;Research Personnel;response;Risk;Science;socioeconomics;Stroke;Stroke prevention;success;symposium;Symptom Burden;Technical Expertise;Therapeutic;Time;Training;treatment and outcome;Universities;Warfarin;willingness;Woman;Work

PROJECT_TITLE: Understanding Oral Anticoagulation Use and Success Among Patients with Psychiatric Multimorbidity in Atrial Fibrillation


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Neurosciences

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Narrative One of the most common and serious auditory complaints is difficulty understanding speech in complex environments containing multiple sound sources and reflections. Many millions of people have difficulty in such environments, especially older people and those with hearing loss. The long-term goal of our work is to understand the binaural and spatial hearing mechanisms through which listeners can succeed in these complex auditory environments, leading, ultimately, to better evidence-based treatment approaches for individuals suffering from hearing loss.

PI_NAMEs: FREYMAN, RICHARD L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 3-Dimensional;Algorithms;Auditory;Awareness;Binaural;binaural hearing;Clinical;clinical practice;Complex;Consensus;Cues;Detection;Dissociation;Ear;Environment;evidence base;Evidence based treatment;Future;Goals;Head;Hearing;Hearing Aids;hearing impairment;Hearing problem;improved;Individual;interest;Knowledge;Light;Literature;Location;Methods;microphone;Minority;Noise;Older Population;Patients;Persons;Play;Positioning Attribute;Psychoacoustics;Psychophysics;Publishing;Research;Role;Safety;Services;signal processing;Signal Transduction;sound;Sound Localization;Source;Space Perception;Specific qualifier value;Speech;speech recognition;Stimulus;Testing;Time;tool;Unilateral Hearing Loss;Work

PROJECT_TITLE: Spatial hearing in complex sound fields

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative We propose to develop a high-throughput technology that measures the single-cell variability of diverse promoters in different chromosomal environments. This technology will illuminate the features of the genome that control a fundamental property of gene expression: the individual differences between genetically identical cells in the same environment.

PI_NAMEs: COHEN, BARAK A (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Analysis of Variance;Area;Bar Codes;Biological Assay;Biology;cancer cell;Cell Reprogramming;cell type;Cells;chemotherapy;Chromatin Remodeling Factor;chromosomal location;Chromosomes;Coupled;Data;Development;Disease;DNA Sequence Alteration;DNA-Binding Proteins;Enhancers;Environment;Epigenetic Process;epigenomics;Gene Expression;Genes;Genome;Genomics;Goals;Heterogeneity;high throughput analysis;high throughput technology;Individual Differences;Location;Malignant Neoplasms;Maps;Measures;Melanoma;Messenger RNA;Molecular;Molecular Conformation;mRNA Expression;Outcome;Penetrance;Play;Post-Translational Protein Processing;Production;progenitor;programs;promoter;Promoter Regions;Property;Protocols documentation;Resistance;Resources;Role;single cell sequencing;Techniques;Technology;therapy resistant;transcription factor;transgene expression;Transgenes

PROJECT_TITLE: High-throughput analysis of the effects of gene promoters and chromosomal environments on single-cell gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(02)M]