NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Digestive Diseases;Genetics;Ovarian Cancer;Pancreatic Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The catalogs of variants in the BRCA1, BRCA2 and Hereditary Breast, Ovarian and Pancreatic (HBOP) cancer genes that will be established as pathogenic or benign are expected to greatly impact clinical management of individuals diagnosed with variants in these cancer genes.

PI_NAMEs: COUCH, FERGUS JOSEPH (contact);SPURDLE, AMANDA BARBARA

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;ATM gene;BARD1 gene;Base Sequence;Benign;brca gene;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;C-terminal;cancer predisposition;Catalogs;CHEK2 gene;Classification;Clinical;Clinical Management;clinical practice;Clinical Trials;clinically relevant;ClinVar;Consensus;Data;Databases;Development;Diagnosis;Disease;Endoscopic Ultrasonography;Family;family genetics;Family member;Genes;genetic testing;Germ Lines;Germ-Line Mutation;Guidelines;Hereditary Malignant Neoplasm;high risk;in silico;Individual;individualized medicine;Inherited;Intervention;Knowledge;loss of function;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammography;Mediating;Medical;Methods;Modeling;Mutation;Odds Ratio;Oncogenes;Operative Surgical Procedures;Ovarian;PALB2 gene;Pancreas;Pathogenicity;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;Prevention;Preventive;Process;prophylactic;Qualifying;RAD51C gene;research clinical testing;Risk;Risk Assessment;Risk Management;RNA Decay;RNA Splicing;Salpingo-Oophorectomy;screening;segregation;Site;Specific qualifier value;Susceptibility Gene;targeted treatment;Testing;Therapeutic;ultrasound;Variant;variant of unknown significance;Vertebral column;web site;Woman;Work

PROJECT_TITLE: BRCA1/2 and Hereditary Breast, Ovarian and Pancreatic (HBOP) Cancer Variant Curation Expert Panels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Many individuals following a set of rules about how to interact with one another and the environment can give rise to a group entity with new properties in a phenomenon known as emergence. To produce emergent behavior, animals must communicate with multiple other individuals while simultaneously processing sensory cues from the environment and then integrate this information into a cohesive behavioral output. While emergent behaviors have traditionally been challenging to study, my discovery of bidirectional spiraling as a novel emergent behavior in the highly tractable nematode C. elegans presents an opportunity to elucidate the communication mechanisms and neural dynamics underlying a collective behavior with implications for disorders marked by failure to integrate sensory and social cues.

PI_NAMEs: PERSSON, LAURA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: Emergent Behavior in a Dish: Discovery of Bi-directional Spiraling as a Population Phenomenon in C. elegans Enables In-Depth Dissection of Mechanisms Underlying Group Behaviors


ADMINISTERING_IC: DE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: Narrative Current replacements for tooth enamel for individuals with disease or damage lack the superior materials properties of healthy enamel. Our proposal is to understand the fundamental mechanisms of biomineralization in order to reveal how the primary protein present during enamel formation, amelogenin, directs and controls this process. This understanding can ultimately aid our ability to develop enamel replacements with similar properties to naturally formed, healthy enamel.

PI_NAMEs: SHAW, WENDY J (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Adsorption;Affect;Amelogenesis Imperfecta;amelogenin;Amino Acid Substitution;Amino Acids;Atomic Force Microscopy;Binding;biomineralization;calcium phosphate;Coupled;Crystallization;Dental Enamel;design;Development;Disease;Enamel Formation;Extracellular Matrix;falls;Goals;Growth;Hydroxyapatites;In Situ;In Vitro;in vivo;Individual;insight;Ions;Knockout Mice;Knowledge;malformation;Maps;Microscopic;mineralization;Minerals;Modification;Molecular;Morphology;mouse model;Mus;Mutation;N-terminal;nanoscale;Nanosphere;Natural regeneration;Nature;Needles;Outcome;particle;Persons;Phase;Phase Transition;Phenotype;prevent;Process;Property;protein distribution;protein protein interaction;protein structure;Proteins;Raman Spectrum Analysis;repaired;Research;Roentgen Rays;Role;Scanning;Site;solid state nuclear magnetic resonance;Spatial Distribution;spatial relationship;Spectrum Analysis;Structure;System;Techniques;Therapeutic;Time;Tissues;tomography;tool;transmission process;Variant;Vertebrates;Work;X ray microscopy

PROJECT_TITLE: Structural, spatial, and temporal features guiding amelogenins transformation of calcium phosphate into enamel

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative As human aging and the resulting age-associated diseases are among the greatest challenges in our healthcare system, there is an urgent need to find interventions that prevent, delay, or even reverse these pathologies. While reducing GH action is highly effective in improving healthspan and lifespan in mice, aging is a complex, multifactorial process that will likely require targeting multiple pathways simultaneously for optimal benefits. Thus, the goal of this proposal is to evaluate gerotherapeutic strategies that combine GHR antagonism with other promising life extending compounds to reduce age-related disease and maximally enhance healthspan.

PI_NAMEs: KOPCHICK, JOHN JOSEPH (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acarbose;Acromegaly;Affect;Age;age related;age-related disease;Aging;aging mechanism;aging process;aging related;Animal Model;antagonist;anti aging;Autopsy;B-Lymphocytes;Binding;blood glucose regulation;Caenorhabditis elegans;Cattle;Cell Aging;Clinical;clinical application;cognitive function;cohort;Combined Modality Therapy;Complex;Consensus;Dasatinib;Data;Development;Diabetes Mellitus;drug candidate;Economic Burden;Elderly;end of life;Estradiol;Exhibits;Exposure to;extend lifespan;FDA approved;Female;Fibrosis;frailty;FRAP1 gene;Future;gerotherapeutic;Goals;Growth and Development function;Growth Hormone Receptor;Health;Healthcare Systems;healthspan;healthy aging;Human;Hyperinsulinism;improved;Individual;Injections;innovation;insulin sensitivity;Insulin-Like Growth Factor I;Intervention;Knockout Mice;Laboratories;Laboratory mice;Life;life span;Link;Longevity;male;Malignant Neoplasms;Measures;Metformin;Methods;Molecular;Mus;Mutation;novel;Nutraceutical;Obesity;older adult;Pathology;Pathway interactions;Patients;pegvisomant;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;Physiological;Predisposition;prepuberty;prevent;Process;Production;Quercetin;Receptor Gene;renal damage;Research;Role;senescence;senescent cell;senolytics;Serum;sex;Sirolimus;Somavert;synergism;Testing;Therapeutic;Time;Transgenic Mice;Work

PROJECT_TITLE: Combining GHR antagonism with life extending compounds: a search for synergies

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Nutrition

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Understanding the molecular rules and network logic of macrophage activation has implications for the design of natural and synthetic macrophage-targeted technologies for controlling inflammatory processes. This new knowledge will lead to technological developments needed to harness the properties of macrophages for biological and engineering applications. The impact of these studies is far-reaching for addressing major public health issues associated with activated macrophages, chronic inflammation, and metabolic deficiencies, such as diabetes, obesity, and cancer.

PI_NAMEs: SHIAU, CELIA E (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Adopted;Area;Autoimmune Diseases;autoinflammatory;Biological;Body System;Cells;Chronic;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;design;Development;Diabetes Mellitus;Disease;disorder prevention;Disparate;Engineering;Ensure;Excision;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetic Screening;Glycolysis;Health;high throughput screening;Human;human disease;immune activation;in vivo;in vivo imaging;Inflammation;Inflammatory;Innate Immune System;insight;Intestines;Knowledge;Kupffer Cells;Liver;Logic;Macrophage;Macrophage Activation;Malignant Neoplasms;Metabolic;Metabolism;metabolomics;Microglia;Molecular;monocyte;Mutation;Normal tissue morphology;novel;Obesity;Organ;Oxidative Phosphorylation;pathogen;Play;Process;programs;Property;protein protein interaction;Proteomics;Public Health;receptor;Regulation;Research;Technology;technology development;tissue repair;Tissues;transcriptomics;whole body imaging;Work;Zebrafish

PROJECT_TITLE: Genetic and metabolic regulation of macrophage activation at steady state

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: NARRATIVE Glioblastoma multiforme (GBM) is the most prominent and malignant primary brain tumor confers a dismal median survival of about one year. In this proposal we will test the hypothesis that inhibition of GTP-energy metabolism will serve as a new therapeutic strategy against GBM. We will use pharmacological and molecular approaches that target GTP-energy metabolism in GBM cell culture and in GBM animal tumor models. Public Health Relevance

PI_NAMEs: SASAKI, ATSUO  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Anabolism;Angiogenesis Inhibitors;Animals;Anti-Inflammatory Agents;Automobile Driving;Biochemical;Biogenesis;Biological Models;Biology;Blood Vessels;blood-brain barrier disruption;Brain Neoplasms;cancer cell;Cell Culture Techniques;cell killing;Cell Survival;Cells;Cellular biology;Cerebral Edema;Clinical Trials;clinically relevant;Collaborations;Coupled;Cryoelectron Microscopy;Data;Dependence;design;DNA;DNA lesion;DNA Repair;DNA Sequence Alteration;Edema;Energy Metabolism;Enzymes;FDA approved;Fostering;Free Radicals;Generations;Genetic;Genetic Transcription;Glioblastoma;Glioma;Goals;Growth;Guanosine Triphosphate;Human;Hypertrophy;Immunocompetent;Immunosuppression;IMP Dehydrogenase;IMPDH1 gene;improved;in vivo;inhibitor;Inosine Monophosphate;insight;Ionizing radiation;Isoenzymes;Japan;Knowledge;Laboratories;Link;Lipids;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;Mus;mutant;mycophenolate mofetil;Mycophenolic Acid;Nature;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Oxidoreductase;Pathogenesis;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;phosphatidylinositol 5-phosphate;Phosphotransferases;pre-clinical;preclinical study;Primary Brain Neoplasms;Prodrugs;Productivity;Prognosis;Proliferating;Property;Protein Biosynthesis;public health relevance;Publishing;radiation effect;Radiation Oncology;radiation resistance;Radiation therapy;Reactive Oxygen Species;Regulation;Research;Resistance;Ribosomal RNA;Ribosomes;Roentgen Rays;Role;Secondary to;sensor;Signal Transduction;standard of care;stem-like cell;System;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Transfer RNA;translation to humans;tumor;tumor growth;tumor initiation;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although there are significant sex differences in the expression and onset of major medical and psychiatric disorders, clinical decisions based on research are primarily based on data from men and may often be inappropriate for women. Thus, there remains a strong need for the Harvard BIRCWH program to educate, train, and develop junior investigators who will commit their careers to studying the impact of sex and gender on clinical disorders. Our Harvard BIRCWH program will provide the basis for the development of sex- dependent treatment approaches and public awareness of the importance of these sex-dependent health issues for families and society.

PI_NAMEs: GOLDSTEIN, JILL M (contact);REXRODE, KATHRYN M

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Adult;Affect;Aging;Autoimmune Diseases;Basic Science;bench to bedside;Boston;Brain;Cardiovascular Diseases;career;Career Mobility;child bearing;Clinical;Clinical Research;Dana-Farber Cancer Institute;Development;differential expression;Disease;disorder risk;Endocrine;Etiology;Exposure disparity;Faculty;Female;Fetal Development;General Hospitals;Genes;health difference;health disparity;Heart;Home;Hormones;Hospitals;Incidence;Institution;Interdisciplinary Study;interest;Israel;life span;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Medicine;men;Menopause;Mentors;Mission;Modeling;Morbidity - disease rate;neuropsychiatric disorder;Neurosecretory Systems;next generation;Pediatric Hospitals;programs;Puberty;Public Health Schools;Recording of previous events;reproductive;Research Institute;Resources;Role;Scientist;sex;Sex Differences;Sexual Dysfunction;Site;socioenvironmental factor;Structure;Thinking;Training;Training Programs;translational approach;Treatment Efficacy;Woman;Women's Health;Work

PROJECT_TITLE: Hormones and Genes in Women's Health: From Bench to Bedside


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE Disturbances in effort-based cost-benefit decision making are prominent in depression, schizophrenia and substance use disorders. This project seeks to determine the neural circuit mechanisms by which the value of effortful actions are evaluated and translated into action selection. Our research will reveal key loci of potential dysfunction and therapeutic intervention in psychiatric disorders.

PI_NAMEs: WILKE, SCOTT ALLEN (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Role of prefrontostriatal circuits in effort-based, cost-benefit decision making

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Nanoparticle translation to the clinic is lacking in large part due to limited accumulation in target disease sites, a particular problem for heterogeneous cancers like ovarian cancer, which can be attributed to the complexity of both the biological environment and the nanoparticle constructs. There is an urgent need to develop tools to deconvolute the individual factors that contribute to nanoparticle accumulation and unlock the unrealized potential of cancer nanomedicine. Therefore, this proposed study seeks to provide a holistic evaluation of nanoparticle structure-function relationships by utilizing a new chemical barcoding strategy to identify materials properties associated with favorable biodistributions and tumor targeting, enable the elucidation of genetic components correlated with nanoparticle interactions, and allow us to leverage the identified genetic signatures for more effective targeted drug delivery.

PI_NAMEs: BOEHNKE, NATALIE  (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Advisory Committees;Affinity;Agar;anti-cancer research;aryl halide;Bar Codes;Binding;Biodistribution;Biological;Biology;Cancer Biology;cancer cell;Cancer cell line;carboxylate;career;Cell Communication;Cell Line;Cells;Characteristics;Chemical Engineering;Chemicals;Chemistry;chemotherapy;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Cytolysis;delivery vehicle;Detection;detection limit;Development;Disease;Disease Resistance;DNA;Dose;Drug Delivery Systems;Drug Targeting;Environment;Evaluation;Flow Cytometry;Fluorescence;Formulation;Genes;Genetic;genetic signature;Genomics;Goals;Heterogeneity;high throughput analysis;Immune;Immunocompetent;Immunocompromised Host;In Vitro;in vivo;in vivo evaluation;Individual;Institution;Knock-out;Label;Magic;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Fragmentography;Mass Spectrum Analysis;materials science;Mediating;Mentorship;Mesenchymal;Modality;Modeling;multiple omics;Mus;nanocarrier;nanomedicine;nanoparticle;nanoparticle delivery;neoplastic cell;novel therapeutics;Organ;particle;Patients;Play;Polymers;Population;pre-clinical;Property;protein expression;Recurrence;Research Personnel;Research Proposals;Sampling;screening;self assembly;Site;Sorting;Structure-Activity Relationship;success;Surface;Survival Rate;System;targeted treatment;Techniques;Technology;Therapeutic Uses;therapy resistant;Time;Tissues;tool;trafficking;Training;transcriptome sequencing;Translating;Translations;tumor;Tumor Biology;tumor heterogeneity;uptake;Validation;Work

PROJECT_TITLE: Understanding drug delivery through an integrated barcoding approach

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE This application will train patient-oriented researchers in dementia care and prevention within the lens of health equity. It leverages two outstanding programs at UCSF to provide a novel curriculum and environment for training and supports the development of leaders who will address dementia in vulnerable communities across the U.S.

PI_NAMEs: MILLER, BRUCE L;VALCOUR, VICTOR  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TITLE: Research Fellowship for Equity in Alzheimer's Disease and Brain Health


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE TET-dioxygenase are the gatekeeper of efficient transcription that regulate cell lineage fate, proliferation and survival. TET2 is one of the major TET-dixygenase that is most frequently mutated in many healthy elderly, wherein its presence put them at significantly higher risk of developing myelodysplastic syndromes and associated disorders. Naturally existing 2HG producing neomorhic mutations in IDH1/2 causes TET-inhibition which in turn leads to the preferential elimination of TET deficient TET2MT hematopoietic clones in human body as observed upon analysis of large cohort of patient data. Hence, establishing TET enzymes as a therapeutic targets. This proposal will enable us to develop small molecule lead compound for early as well as late therapeutic intervention and allow us to gain insights into strategies by which this might be achieved.

PI_NAMEs: JHA, BABAL K;MACIEJEWSKI, JAROSLAW P. (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Affect;Agreement;Alleles;alpha ketoglutarate;Ascorbic Acid;Biochemical;Biological;Biological Assay;biomarker identification;Bone Marrow;cancer cell;Cardiovascular Diseases;CD34 gene;Cell Line;Cell Lineage;Cell model;Cells;Clinical;Code;cohort;CpG Islands;Data;demethylation;Development;diagnostic biomarker;Dioxygenases;Disease;DNA;DNMT3a;Dysmyelopoietic Syndromes;Elderly;enantiomer;Enhancers;Enzymes;Epigenetic Process;Event;Evolution;FLT3 gene;Gatekeeping;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterozygote;high risk;histone demethylase;Human;Human body;Human Cell Line;improved;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;insight;Investigation;knock-down;Knock-out;Lead;Lesion;leukemia;Libraries;Life;loss of function;loss of function mutation;Maintenance;Malignant - descriptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Messenger RNA;Methylation;Modeling;Modification;Molecular;Morphology;mouse model;Mus;mutant;Mutate;Mutation;mutational status;Myelogenous;Myeloid Cells;Myeloproliferative disease;Neoplasms;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;oxidation;Pathogenicity;Patients;pharmacologic;Phenotype;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical development;preclinical trial;predicting response;prevent;Prevention strategy;Production;programs;Proliferating;promoter;rational design;Residual state;response;Site-Directed Mutagenesis;small molecule;Somatic Mutation;Specificity;Structure;targeted treatment;Testing;Tetanus Helper Peptide;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Time;Transcriptional Regulation;Transplantation;Treatment Efficacy;Work

PROJECT_TITLE: Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Botulinum neurotoxins pose a significant threat to the nation as a potential bioterrorism agent. Here we propose to create a novel protein-based delivery platform that can deliver small nanobodies into the cytosol of motor neurons to neutralize botulinum neurotoxins. These studies will not only provide an effective post-exposure treatment for a top-priority toxin, but also establish a modular delivery tool for targeting motor neurons and delivering biologics into the cytosol of neurons.

PI_NAMEs: DONG, MIN  (contact)

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: Animal Model;Animals;Antibodies;Bacteria;Bacterial Toxins;Binding;Biological Products;Bioterrorism;botulinum toxin treatment;Botulinum Toxin Type A;Botulinum Toxins;Botulism;Cardiovascular system;Categories;Cavia;Cessation of life;Chimeric Proteins;Clostridium;Cytosol;Dangerousness;Data;Death Rate;design;Development;Disease;Disease Outbreaks;Drug Delivery Systems;Drug Kinetics;efficacy validation;Engineering;exhaust;Family;Family member;fragment X;guinea pig model;Half-Life;Hour;Human;improved;in vivo;innovation;Intoxication;Lead;Medical;member;Membrane;Methods;Modeling;motor neuron degeneration;Motor Neurons;Mus;Muscle;nanobodies;Neurons;Neurotoxins;neutralizing antibody;novel;Paralysed;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Population;pre-clinical;Process;Production;protein degradation;Protein Engineering;Proteins;prototype;Rattus;receptor binding;Reproduction spores;Residual state;Resources;Respiratory Failure;Respiratory Mechanics;Rodent;Signal Transduction;Specificity;success;systemic toxicity;targeted delivery;Testing;Therapeutic;therapeutic protein;tool;Toxic effect;Toxin;Toxin Conjugates;Treatment Efficacy

PROJECT_TITLE: Targeted Delivery of Therapeutics into Motor Neurons for Post-exposure Treatment of Botulism

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: SOUTHEAST CLINICAL ONCOL RES CONSORTIUM

PHR: SCOR Project Narrative Advances in oncology are made through the execution of well-designed innovative clinical trials, including participation in Cancer Care Delivery Research, and these advances will lead to improved quality of life and health outcomes, as well as reducing cancer health disparities. This 21-community organization has the expertise, strength, capacity, and capability to contribute to these outcomes. Through covering a six-state area, this organization provides clinical trial access to small, rural, medically underserved, and Appalachia communities of the Southeast.

PI_NAMEs: HOPKINS, JUDITH O;IRVIN, WILLIAM J (contact);PENNINGTON, JOSEPH DANIEL

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Advocate;Aftercare;age group;Appalachian Region;Area;base;cancer care;Cancer Control;cancer health disparity;cancer therapy;care delivery;caregiver quality of life;Caregivers;Caring;Catchment Area;Clinical;clinical imaging;Clinical Oncology;Clinical Research;Clinical Trials;Communities;Community Clinical Oncology Program;Community Hospitals;community organizations;data submission;design;Development;Education;Emergency Medicine;Ensure;Ethnic Origin;Evidence Based Medicine;Evidence based practice;experience;Florida;Funding;Gastroenterology;Geographic Locations;Geographic state;Goals;Gynecology;Health;health care delivery;health care disparity;Hospitals;human subject protection;improved;Infrastructure;innovation;Leadership;Malignant Neoplasms;medically underserved;medically underserved population;member;Mentors;metropolitan;Minority Groups;Monitor;National Cancer Institute;National Clinical Trials Network;next generation;North Carolina;Oncology;operation;Operative Surgical Procedures;Outcome;Palliative Care;Participant;patient population;Patients;performance site;Persons;Population;precision medicine;Preparation;Prevention;Primary Care;Principal Investigator;Private Practice;programs;Quality of Care;Quality of life;Radiology Specialty;recruit;Research;Research Institute;Research Personnel;research study;Rural;rural underserved;Scientific Advances and Accomplishments;screening;Site;Site Visit;South Carolina;System;targeted treatment;Tennessee;Training;Underserved Population;Urology;Virginia

PROJECT_TITLE: NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Rare genetic disorders are a major cause of human morbidity, frequently affect brain development and cause neurodevelopmental disorders (such as attention deficit hyperactive disorder – ADHD). Here we focus on Noonan syndrome (1:2000 individuals). We use advanced brain imaging and psychological testing to understand how the genetic condition (Noonan syndrome) affects the brain and gives rise to neurodevelopmental disorders.

PI_NAMEs: GREEN, TAMAR  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 16 year old;Acceleration;Address;Affect;Animal Model;Anisotropy;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autosomal dominant mutation;Biological Models;Biology;Brain;Brain imaging;Brain region;brain tissue;Caenorhabditis elegans;Child;Child Psychiatry;clinical application;comparison control;Complex;computational neuroscience;connectome;connectome based predictive modeling;Copy Number Polymorphism;Corpus striatum structure;Correlation Studies;Data;density;Development;Disease;gain of function;gain of function mutation;Genes;Genetic;Genetic Diseases;genetic risk factor;genetic testing;genetic variant;Genomics;Human;human model;human morbidity;imaging modality;imaging study;in silico;In Vitro;in vivo;Individual;innovation;insight;interest;Investigation;Learning Disabilities;Location;Maps;Measures;Methods;Mitogen-Activated Protein Kinases;Modality;Modeling;Molecular;molecular dynamics;Molecular Genetics;Mutation;Myelin;Neurodevelopmental Disorder;neuroimaging;non-invasive imaging;Noonan Syndrome;Outcome;Pathogenicity;Pathway interactions;Penetrance;Phenotype;Phosphorylation;Predisposition;Prognosis;Proteins;Psychological Tests;PTPN11 gene;RAF1 gene;rare genetic disorder;Rest;Restriction Spectrum Imaging;Risk;Role;Sampling;Severities;Signal Transduction;src Homology Region 2 Domain;Structure;Surface;Symptoms;Syndrome;System;Testing;Thick;Time;Translating;Up-Regulation;Variant;white matter;Work

PROJECT_TITLE: Gaining insights: the effects of the RMK gain-of-function mutations on brain development and neurodevelopmental disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Orphan Drug;Precision Medicine;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Pulmonary arterial hypertension (PAH) is a rare condition characterized by gradual occlusion of the small pulmonary arterioles leading to progressively increased pulmonary vascular resistance (PVR), right heart failure and death. Although causal mechanisms are unclear, our data, for the first time, show evidence of common genetic variation in two novel gene targets associated with the risk of developing PAH in the largest available PAH cohort studied to-date. Our studies will now shed insight into whether these two novel modifier genes contribute to the risk of disease progression and outcomes as well as provide new potential therapeutic targets in PAH.

PI_NAMEs: DESAI, ANKIT A;NICHOLS, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;African American population;Alleles;anakinra;arteriole;Attenuated;biobank;Biological;Biology;BMPR2 gene;Candidate Disease Gene;Cell Physiology;Cessation of life;Clinical;Clinical Data;clinical risk;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Data;Data Reporting;Data Set;Death Rate;Development;Disease Outcome;Disease Progression;disorder risk;Endothelial Cells;Endothelium;Enhancers;Ethnic Origin;Ethnic Population;European;European ancestry;exome sequencing;Female;Funding;Gene Expression;Gene Modified;Gene Targeting;Genes;Genetic;genetic association;Genetic Diseases;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genotype;Goals;Health;Heritability;Hispanic Populations;Histocompatibility Antigens Class II;Histology;HLA-DPB1 gene;HMG-Box Domains;Human;hypertension control;hypertension treatment;Hypoxia;improved;Inflammation;Inflammatory;inhibitor;insight;Interleukin-1;International;Lead;Link;Lung;Mass Spectrum Analysis;Mediating;Meta-Analysis;Metabolic;metabolomics;Minority;Minority Groups;Mitochondria;Modeling;mortality;Multiomic Data;Mus;Mutation;new therapeutic target;novel;Outcome;overexpression;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population Heterogeneity;precision medicine;Preclinical Testing;predict clinical outcome;Prognosis;Publishing;pulmonary arterial hypertension;Pulmonary Vascular Resistance;Quantitative Trait Loci;R24;rare condition;rare variant;Registries;Regulation;Reporting;response;right ventricular failure;Risk;Risk Factors;risk stratification;risk variant;Rodent;Role;Smooth Muscle;Smooth Muscle Myocytes;SOX17 gene;Spain;Testing;therapeutic target;Time;tool;transcription factor;transcriptome sequencing;treatment response;Validation;Variant;Vital Status;Whole Blood;whole genome

PROJECT_TITLE: Risk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH Biobank

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PHR: ClinGen CHD ECP Project Narrative  The ClinGen Congenital Heart Disease Expert Curation Panel comprises members from around the world with expertise in cardiovascular genetic research, cardiac development, clinical care, and commercial diagnostic genetic testing. In a well-organized, ClinGen-compliant manner, the Panel will curate gene- congenital heart disease pairs and classify their variants.

PI_NAMEs: GELB, BRUCE D;ROBERTS, AMY E (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Address;Affect;Animal Model;Attention;autism spectrum disorder;Benign;bicuspid aortic valve;Biochemical;Biological Assay;Birth;Boston;Candidate Disease Gene;Cardiac;cardiogenesis;Cardiovascular Diseases;Cardiovascular system;Cells;Classification;Clinical;clinical care;clinically relevant;clinically significant;ClinVar;Collaborations;Communication;Communities;comorbidity;Complex;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Data;Development;Diagnosis;Diagnostic;Disease;Epidemiology;exome sequencing;experience;Funding;Genes;Genetic;genetic architecture;genetic panel test;Genetic Research;genetic testing;Genetic Variation;Genome;genome-wide;Genotype;Goals;Heart Abnormalities;Heritability;Human Genetics;Individual;Infant;insertion/deletion mutation;Intellectual functioning disability;interest;International;Laboratories;Medical Genetics;member;Mentors;Mutation;Newborn Infant;next generation sequencing;novel;Outcome;outreach;Participant;Pathogenesis;Pathogenicity;Patients;Pediatric Cardiac Genomics Consortium;Phenotype;Procedures;Qualifying;Research;research clinical testing;Review Literature;Risk;Role;Science;Single Nucleotide Polymorphism;Structural defect;Syndrome;Testing;Training;trait;United States National Institutes of Health;Variant;Work


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Dr. James J. Prisciandaro is a licensed Clinical Psychologist, Associate Professor in the Addiction Sciences Division of the Department of Psychiatry & Behavioral Sciences at the Medical University of South Carolina (MUSC), who is committed to making a measurable impact on our understanding and ability to treat individuals with bipolar (BD) and/or substance use disorders (SUD) through his program of patient-oriented research (POR). Although he has been successful in designing and executing NIH-funded pharmaco-imaging studies, his efforts to mentor new clinical investigators have been greatly limited by his employment within an academic medical center that does not provide faculty with protected time for mentoring or professional development. The proposed K24 award would provide Dr. Prisciandaro with the protected time and supplementary funding needed to comprehensively train significantly more new clinical investigators and to develop and expand his methodological skills to include genomics research.

PI_NAMEs: PRISCIANDARO, JAMES JOSEPH (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Academic Medical Centers;addiction;alcohol cue;alcohol response;alcohol use disorder;Area;Award;Behavioral Sciences;Bioinformatics;Biological Psychiatry;biomedical imaging;Biometry;Blood specimen;Brain;career;Clinical;Clinical Investigator;cost;Data;design;Development;Diagnosis;Employment;experience;Exposure to;Faculty;Funding;Future Generations;gabapentin;gamma-Aminobutyric Acid;genetic variant;genomic variation;Genomics;Glutamates;Goals;Grant;Image;imaging study;improved;Individual;Investigation;Licensing;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurable;Medical;meetings;member;Mentors;Mentorship;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Monitor;multimodality;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;neurochemistry;Participant;participant enrollment;patient oriented research;Pharmaceutical Preparations;pharmacologic;Phenotype;Postdoctoral Fellow;Productivity;programs;Protons;psychiatric genomics;Psychiatry;psychogenetics;Psychologist;recruit;Research;Research Methodology;research study;Resources;Science;Scientist;skills;Source;South Carolina;statistics;Substance Use Disorder;success;Time;Training;United States National Institutes of Health;Universities;Wages;Work

PROJECT_TITLE: Mentorship and Research in Bipolar and Substance Use Disorders

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The central nervous system (CNS) arguably represents the most difficult anatomical tissue location to access and to evaluate for viral infection and persistence. Here we propose to investigate the dynamics of viral reservoir cells in CNS cells from antiretroviral treated HIV-1-infected individuals, using a recently-developed single-cell technology pipeline. These studies may provide insights for targeted HIV cure interventions in people living with HIV-1.

PI_NAMEs: MUKERJI, SHIBANI SHARON;YU, XU  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Affect;Anatomy;Anti-Retroviral Agents;Astrocytes;ATAC-seq;Autopsy;Behavior;Biological Assay;Blood;Blood Vessels;Body System;Brain;brain cell;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Assay;Central Nervous System;Characteristics;ChIP-seq;Chromatin;chromosomal location;Clinical;Clonality;Colon;Combined Modality Therapy;Communicable Diseases;comparative;Competence;Cytosine;Epigenetic Process;Evaluation;fitness;Frequencies;Functional disorder;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genome analysis;genome-wide;Genomics;glial activation;Goals;Heterochromatin;histone modification;Histones;HIV;HIV-1;Human;Human body;Human Genome;ileum;Immune;Immunohistochemistry;Immunologics;In Situ Hybridization;Individual;Infection;insight;integration site;interdisciplinary collaboration;Interruption;Intervention;Investigation;Length;Location;lymph nodes;Lymphoid Tissue;Macrophage;Mediating;Methylation;Microglia;Myelogenous;NCOA6 gene;Neurocognitive;Neuroglia;Neurology;neuropathology;neutralizing antibody;next generation sequencing;novel;Pathogenesis;Patient Care;Patients;Persons;Phylogenetic Analysis;Positioning Attribute;Predisposition;Proviruses;Research Personnel;Resolution;response;RNA;Role;Sampling;Signal Transduction;single cell technology;single molecule;Sorting;T-Lymphocyte Epitopes;Technology;Testing;Tissues;Transcription Initiation Site;Untranslated RNA;Viral;viral rebound;Viral reservoir;virology;Virus Diseases;Virus Integration;Work

PROJECT_TITLE: Characterizing HIV-1 reservoirs in the central nervous system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Hepatocellular carcinoma (HCC) is one of the fastest growing causes of cancer-related deaths among Americans, and it disproportionately affects African Americans. Differences in prevalence of established HCC risk factors do not fully explain the high HCC burden in African Americans, and clinical interventions and policies to close these racial gaps have been largely ineffective because fundamental questions about how this disparity arises remain unanswered. Using a genome-wide association study approach, our research aims to identify and validate genetic factors that predispose to the development of HCC in African Americans and contribute to the racial disparities in HCC incidence.

PI_NAMEs: THRIFT, AARON PETER (contact)

PROGRAM_OFFICER_NAME: KALIA, SARAH SUJATA

PROJECT_TERMS: Affect;African American;African American population;African ancestry;Alleles;American;Architecture;Asian ancestry;Attention;Biological Specimen Banks;blood-based biomarker;Cancer Etiology;Cancer Patient;cancer site;Case/Control Studies;Categories;Cessation of life;Cirrhosis;Clinical;clinical application;cohort;comparison group;cost efficient;Data;design;Development;Disease;Disparity;Early Diagnosis;Environmental Risk Factor;Epidemiology;ethnic difference;ethnic disparity;Ethnic Origin;Etiology;European;Evaluation;follow-up;Genetic;genetic epidemiology;genetic information;Genetic Markers;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genotype;Germ Lines;Germ-Line Mutation;Goals;high risk;high risk population;Incidence;Individual;Infrastructure;insight;Intervention;Investigation;Knowledge;liver cancer model;Machine Learning;Malignant Neoplasms;Modeling;Molecular;next generation sequencing;non-genetic;Not Hispanic or Latino;novel;Nucleotides;Pathway interactions;Patients;Pattern;Phase;Policies;polygenic risk score;Population;Predisposition;Prevalence;Prevention;Primary carcinoma of the liver cells;prospective;Race;racial difference;racial disparity;Relative Risks;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;Role;screening;Survival Rate;Texas;Underserved Population;Validation;Variant;α-Fetoproteins

PROJECT_TITLE: Genetic Epidemiology of Hepatocellular Carcinoma in African Americans

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cost Effectiveness Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ZOOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Knowledge of the factors influencing pathogen spread in vector populations is critical for understanding dynamics of disease incidence, development of risk assessment strategies for novel pathogen introductions and development of transmission biomarkers that can be used to efficiently target control efforts. Since its introduction in 1999, the Category B Priority Pathogen West Nile Virus (WNV) spread completely across the United States with over 50,000 confirmed human cases and over 2,000 deaths. In this proposal, we will delineate the hologenomic (genetics of the mosquito and its associated microorganism) factors underlying WNV infection variation across field populations of Culex tarsalis. These results can be used to develop biomarkers for pathogen transmission in natural mosquito populations that can be used for targeting control efforts, and for use in risk assessment strategies to predict the likelihood of pathogen invasion during natural introductions or bioterrorist attacks.

PI_NAMEs: RASGON, JASON L (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Affect;Attention;Bacteria;Biological Markers;biomarker identification;Bioterrorism;candidate validation;Categories;Category B pathogen;Cessation of life;Chromosome Mapping;Cluster Analysis;Communities;Correlation Studies;cost;Cost Effectiveness Analysis;Culex (Genus);Culicidae;Data;Development;Disease;Disease Outbreaks;disorder control;Effectiveness;emerging pathogen;Epidemiology;Event;experimental study;fungus;Gene Frequency;Genes;Genetic;Genetic Population Study;Genetic Recombination;Genetic Structures;Genetic Variation;genome wide association study;genomic locus;Genotype;Human;in vivo;Incidence;Individual;Infection;Insecta;insight;interest;Invaded;Knowledge;Laboratories;Microbe;microbial;microbiome;microbiome components;microorganism;Microsatellite Repeats;migration;mosquito-borne pathogen;novel strategies;Organism;pathogen;Pattern;Phenotype;Population;Population Genetics;Population Sizes;Process;Quantitative Trait Loci;Research;Resolution;Risk Assessment;Role;Sampling;specific biomarkers;Statistical Methods;statistics;Surveys;System;Technology;Time;transmission process;United States;Variant;vector;vector competence;vector mosquito;viral resistance;Virus;West Nile viral infection;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Hologenomic basis of WNV vector competence in Culex tarsalis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Children with congenital heart diseases (CHD) often demonstrate neurodevelopmental deficits – that manifest as difficulties with language, cognitive tasks, and impaired executive function – and the risk factors that may contribute to this poor outcome remains elusive. Based on prior studies, altered CSF volumes and perturbation to CSF circulation may play a role in poor neurodevelopmental outcomes in CHD. This study aims to establish the relationship between abnormalities in CSF, as quantified using multi-modal magnetic resonance imaging techniques and neurodevelopmental deficits in children and adolescents with CHD.

PI_NAMEs: LEE, VINCENT KYU (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adolescent;Adult;Age;autism spectrum disorder;Blood Vessels;Brain;brain health;brain parenchyma;Cerebellum;Cerebrospinal Fluid;cerebrospinal fluid flow;Characteristics;Child;Childhood;Circulation;Cognitive;Cognitive deficits;cognitive task;cognitive testing;congenital heart abnormality;Congenital Heart Defects;Cyanosis;Dementia;Department of Defense;Detection;Development;Diagnosis;Disease;Early Diagnosis;Early Intervention;Education;Elderly;Environment;Executive Dysfunction;executive function;Exhibits;Face;Funding;General Population;Goals;Growth;heart defect;Hippocampus;Human;Hypoxia;Image;imaging biomarker;Imaging Techniques;Impaired cognition;Impairment;improved;in vivo;Individual;Inflammatory;Intraventricular;Language;lateral ventricle;Lead;Link;Live Birth;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Memory;Multimodal Imaging;multimodality;Nervous System Disorder;Neurobiology;neurodevelopment;Neurodevelopmental Deficit;neuronal growth;Neurons;Neuropsychological Tests;Nutrient;older patient;olfactory bulb;Operative Surgical Procedures;Outcome;Participant;Patients;Pediatric Hospitals;pediatric patients;peer;Phase;Play;Production;prognostication;Property;Proteins;Quality of life;Risk Factors;Role;Severities;Shapes;Signal Transduction;Site;Social Interaction;Structure;Subarachnoid Space;Survival Rate;System;T2 weighted imaging;Techniques;Testing;Thick;Third ventricle structure;United States;United States National Institutes of Health;Variant;wasting

PROJECT_TITLE: Quantitative Magnetic Resonance Properties of Cerebrospinal Fluid and Brain Health Outcomes in Pediatric Congenital Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE The brief alcohol intervention (BAI) improves antiretroviral therapy adherence and increases viral suppression among people with HIV (PWH) with unhealthy alcohol use, reducing the possibility that they may transmit the virus. The BAI is ready for scale-up in ART clinics, but its effectiveness may be impaired by the alcohol-related attitudes and behaviors among clinic staff, especially in regions where excessive alcohol use is normative. This trial will identify the best way to scale up the BAI in ART clinics in Vietnam by giving some clinic staff the opportunity to experience the BAI themselves, before they are asked to give the BAI to PWH with unhealthy alcohol use.

PI_NAMEs: GO, VIVIAN F. (contact);MILLER, WILLIAM C

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Active Learning;Address;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol misuse;alcohol use disorder;Alcohols;antiretroviral therapy;arm;Attitude;Behavior;brief alcohol intervention;Characteristics;Classification;Clinic;Clinical;Cognitive Therapy;cohort;Consent;cost;Counseling;drinking;effective intervention;Effectiveness;effectiveness outcome;Ensure;expectation;experience;flexibility;General Population;Health;Health Personnel;High Prevalence;HIV;HIV Infections;Hybrids;Impairment;implementation barriers;implementation intervention;implementation outcomes;implementation strategy;implementation trial;improved;Incidence;Injections;Intervention;intervention delivery;Measures;Mediating;Methods;motivational enhancement therapy;novel;Nurses;optimism;organizational climate;Outcome;Pathway interactions;Penetration;Persons;Physicians;Positioning Attribute;prevent;Professional counselor;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;recruit;reduced alcohol use;Reporting;Resources;Risk;scale up;secondary outcome;skills;social;social expectations;Staff Attitudes;standard of care;therapy adherence;tool;Training;Translating;transmission process;treatment as prevention;trial comparing;Uncertainty;uptake;Vietnam;Vietnamese;Viral;viral transmission;Virus;Work

PROJECT_TITLE: Scaling up the brief alcohol intervention to prevent HIV infection in Vietnam: a cluster randomized, implementation trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The proposed research will document the extent of disparities in the quality of Medicare-covered nursing home care received, investigate the forces behind those disparities, and evaluate the impact of potential policy interventions on those disparities. The research will focus on disparities across racial and ethnic groups, across socio-economics status, and across health groups (those with and without Alzheimer’s and related dementias).

PI_NAMEs: FINKELSTEIN, AMY N. (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Admission activity;Alzheimer's disease patient;Alzheimer's disease related dementia;black patient;Black race;Caregivers;Certification;cognitive capacity;COVID-19 pandemic;daily functioning;Data;Data Set;Dementia;Disparity;disparity reduction;Dual Enrollment;Elderly;Ethnic Origin;Ethnic Population;experience;Foundations;Funding;Health;health assessment;Heterogeneity;Hispanic;Home Nursing Care;Hospitalization;improved;Intervention;Marketing;Measurement;Measures;Medicaid;Medicare;Medicare/Medicaid;Mental Health;Methods;Not Hispanic or Latino;Nursing Assessment;Nursing Homes;Outcome;Patient Admission;Patient Selection;Patients;Personal Satisfaction;physical conditioning;Policies;Public Policy;Quality of Care;Race;racial population;Research;Role;Socioeconomic Status;Sorting;Source;United States Centers for Medicare and Medicaid Services;Work

PROJECT_TITLE: Disparities in the Quality of Nursing Home Care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE The overall goal of the African Tuberculosis Bioinformatics Training Program is to strengthen bioinformatics training in Africa for infectious diseases, specifically for tuberculosis (TB), a major public health problem on the continent. The Program will address a dearth of trained bioinformaticians with expertise in TB and other infectious diseases, through a structured Master’s in TB bioinformatics, in which trainees will develop subject-specific expertise, complemented by international research visits, and other networking and capacity development opportunities. Trainees will be embedded within a vibrant network of LMIC and US-based mentors who will provide TB biology, bioinformatics and global health expertise together with individual mentoring to support the development of future leaders in infectious disease bioinformatics.

PI_NAMEs: MOLLER, MARLO ;SAMPSON, SAMANTHA LEIGH (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: African;Bioinformatics;Biology;Cancer Center;career development;Clinical Research;Computational Biology;Data;Education;Educational Curriculum;Educational workshop;empowerment;Environment;Evaluation;Faculty;Future;global health;Home;Human Genetics;industry partner;Infectious Diseases Research;Institution;Laboratories;lectures;low and middle-income countries;Madagascar;Mentors;Mentorship;Molecular Biology;Monitor;Mozambique;Namibia;National Institute on Minority Health and Health Disparities;Needs Assessment;Phase;Positioning Attribute;Process;Productivity;Program Development;programs;Reproducibility;Research;Research Personnel;Research Project Grants;Research Training;Scientist;skills;South Africa;Southern Africa;statistics;Structure;student training;Teacher Professional Development;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;Visit;Zambia;Zimbabwe

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (55)]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The skeleton is innervated primarily by NGF (Nerve growth factor)-responsive, TrkA (Tropomyosin receptor kinase A)-expressing sensory nerve fibers. In unpublished work, our laboratory has recently uncovered prominent regulatory roles for these neurons in pathologic bony bar formation after growth plate injury, although the mechanism remains unknown. In the present high risk / high reward proposal, we seek through a combination of approaches to uncover the neuroskeletal regulatory mechanisms which predict this pathologic response to skeletal injury.

PI_NAMEs: JAMES, AARON W (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: afferent nerve;Afferent Neurons;Anatomy;angiogenesis;Animals;Attenuated;attenuation;Blood Vessels;Body System;bone;Bone Growth;Bone Tissue;Cartilage;Cells;chemical genetics;Child;Communication;Deformity;Embryonic Development;Endothelial Cells;Epiphysial cartilage;experimental study;Fiber;Fibroblast Growth Factor;Fracture;Future;genetic approach;Growth;high reward;high risk;Impairment;Infiltration;injured;Injury;innovation;Laboratories;limb injury;Link;Literature;Maps;Methods;Molecular;mouse model;Mus;Nerve;Nerve Fibers;Nerve Growth Factors;nerve supply;neural;neuronal cell body;Neurons;neuroregulation;neurovascular;Pathologic;peripheral blood vessel;Peripheral Nerves;pharmacologic;Phenotype;Phosphotransferases;Physiologic Ossification;Pilot Projects;prevent;Process;receptor;Regulation;repaired;Reporter;Reporting;response;response to injury;Role;Sensory;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Site;skeletal;Skeletal Development;skeletal injury;skeletal tissue;Skeleton;Skin;small molecule;small molecule inhibitor;Soft Tissue Injuries;Specific qualifier value;Spinal Ganglia;System;targeted treatment;Techniques;Tissues;Transforming Growth Factor beta;Transgenic Animals;Transgenic Mice;translational potential;Tropomyosin;unpublished works;Vascular Proliferation;Viral;Visualization;Work

PROJECT_TITLE: Sensory nerve regulation of growth plate repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Invasive pulmonary aspergillosis (IPA) is a significant problem among immunocompromised individuals and has an attributed mortality rate as high as 90% in certain areas of the world. This proposal seeks to alleviate this issue by assessing the killing efficacy of human stem cell-derived neutrophils (iNeutrophils) against the two most prevalent isolates of IPA, Aspergillus fumigatus and Aspergillus flavus. In doing so, this work will provide needed information on the potential of iNeutrophils as a novel antifungal therapeutic against IPA, while also elucidating mechanisms utilized by these cells to facilitate fungal clearance.

PI_NAMEs: WAGNER, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;Allergic Bronchopulmonary Aspergillosis;alternative treatment;anti-fungal agents;Area;Aspergillus;Aspergillus flavus;Aspergillus fumigatus;Attenuated;Azoles;Basophils;beta-glucan receptor;Biological Assay;Caspofungin;Cell Wall;Cells;Clinical Treatment;clinically relevant;combat;combinatorial;Combined Modality Therapy;cytotoxicity;Death Rate;dectin 1;Development;DNA Sequence Alteration;Drug resistance;Economic Burden;engineered stem cells;Engineering;Environment;eosinophil;Ephrins;Epitopes;extracellular;first responder;Fungal Drug Resistance;fungal genetics;fungus;GATA1 gene;Glucans;Goals;granulocyte;Growth;high risk;Human;human induced pluripotent stem cells;human stem cell-derived;Image;Immune;Immune response;Immunocompromised Host;immunogenic;Immunology;In Vitro;Individual;Infection;insight;Invaded;Knock-out;Knowledge;life span;Macrophage-1 Antigen;Mediating;Mediator;Medical;microbial;mutant;Mycoses;neutrophil;novel;pathogenic fungus;Pathogenicity;Patients;Pattern recognition receptor;Pharmaceutical Preparations;Phenotype;Play;Polyenes;Polysaccharides;Positioning Attribute;Production;Public Health;Reactive Oxygen Species;receptor;Regimen;Reporting;Resistance;response;Role;synergism;Techniques;Testing;Therapeutic;training opportunity;transcription factor;Transfusion;Treatment Failure;treatment strategy;United States;Voriconazole;Work

PROJECT_TITLE: Development and characterization of human iPSC-derived neutrophil therapies against pathogenic Aspergilli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Aging;Hematology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Precise regulation of the Wnt signaling pathway is necessary to maintain hematopoietic stem cell (HSC) maintenance and quiescence. After a fracture event, the bone marrow environment, where the HSC niche resides, is then disordered and recruits various inflammatory cytokines as part of the healing process. Injury and age can lead to a dysregulation of Wnt signaling which this proposal hypothesizes alters HSC localization and differentiation, affecting the quality of fracture repair, and thus can be an unexplored target to treat age-related fracture complications.

PI_NAMEs: NGUYEN, TUYET DOAN ANH (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Adenoviruses;Affect;Age;age difference;age related;age related changes;aged;Aging;aging population;aging process;animal old age;Animals;antagonist;Back;beta catenin;Biology;Blood Vessels;bone;bone fracture repair;bone healing;bone health;Bone Marrow;Bone Regeneration;Cell Count;Cell Lineage;Cell Maintenance;cell type;Cells;cytokine;Data;Death Rate;Development;Disease;Environment;Event;experimental study;Fluorescence-Activated Cell Sorting;Fracture;Future;Gene Expression;healing;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell differentiation;hematopoietic stem cell niche;Hematopoietic stem cells;Impairment;In Vitro;in vivo;Inflammaging;Inflammatory;Injury;insight;Laboratories;LoxP-flanked allele;Macrophage;mechanical properties;Mediating;Mesenchymal;migration;monocyte;Mus;Myelogenous;old mice;Older Population;Osteoblasts;Osteoclasts;Osteogenesis;Pathway interactions;Patients;Pattern;Phase;Phenotype;Play;postnatal;Process;Proliferating;recruit;Regulation;repaired;Reporter;Role;Signal Transduction;single-cell RNA sequencing;skeletal;stem cell population;stemness;systemic inflammatory response;targeted treatment;Tibial Fractures;Tomatoes;United States;Universities;WNT Signaling Pathway;Work

PROJECT_TITLE: The impact of Wnt signaling on hematopoietic stem cell aging and its influence on fracture repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Individuals who experience traumatic brain injury (TBI) and repetitive head impacts (RHI) are at increased risk for developing dementia and parkinsonism. This U01 will advance scientific understanding of the specific risks for the development of Alzheimer’s disease (AD) and related disorders (ADRD), chronic traumatic encephalopathy (CTE), and other pathologies after RHI and TBI, establish the neuropathological features of TBI- related neurodegeneration, and determine the association of post-RHI and TBI neuropathologies with dementia and parkinsonism. This project will lay the foundation for future strategies to intervene, prevent, and treat TBI-related neurodegeneration and CTE.

PI_NAMEs: MCKEE, ANN C. (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Adverse effects;Affect;Age;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Astrocytosis;Atrophic;Axon;Blood Vessels;Boston;Brain;Brain region;Cardiovascular Diseases;Caregivers;Characteristics;chronic traumatic encephalopathy;Clinical;Cognitive;Collection;contact sports;Decision Making;Dementia;Deposition;Development;Diagnosis;Emergency Situation;experience;Exposure to;Family;family influence;Foundations;Framingham Heart Study;Frequencies;Future;Genetic;head impact;Impaired cognition;Impairment;in vivo;indexing;Individual;informant;Infrastructure;insight;Interview;Learning;Life Cycle Stages;Magnetic Resonance Imaging;Measures;Medical;Medical Records;Military Personnel;Modeling;Motor;motor symptom;MRI Scans;Myelin;Nerve Degeneration;Nervous System Trauma;neuroinflammation;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neuropsychological Tests;non-genetic;novel;Other Genetics;Outcome;Parents;Parkinsonian Disorders;Pathology;performance tests;Phenotype;Play;Population;Post-Traumatic Stress Disorders;Prevalence;prevent;Process;Proteins;Public Health;Research;resilience;resilience factor;Resistance;resistance factors;Risk;Risk Factors;Scientific Advances and Accomplishments;Severities;social health determinants;Standardization;Structure;Symptoms;Syndrome;tau-1;Testing;Trauma;Traumatic Brain Injury;Universities;Visit;white matter

PROJECT_TITLE: Contributions of Brain Trauma to AD/ADRD Neuropathology, including CTE, and Resulting Clinical Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-O (26)]


ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE  The overall goal of this project is to elucidate the signaling mechanisms underlying the control of muscle growth. Specifically, we will use a combination of genetic and pharmacological approaches in mice to investigate the function of key components of the signaling pathway utilized by myostatin and related proteins. We believe that these studies will be important for developing the most effective strategies to target this regulatory system for clinical applications to treat patients with muscle and metabolic diseases.

PI_NAMEs: LEE, SE-JIN  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: activin A;ACVR2 gene;ACVR2B gene;Binding;Binding Proteins;Biochemical;clinical application;Clinical Pathways;Complex;drug development;Equilibrium;Family member;follow-up;functional outcomes;GDF8 gene;Genetic;Goals;Growth;Homeostasis;In Vitro;in vivo;Individual;insight;Laboratories;Ligands;LoxP-flanked allele;MADH2 gene;MADH3 gene;Mediating;Mediator;member;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modeling;Molecular;mouse model;Mus;Muscle;muscle form;Muscle function;muscle hypertrophy;Muscular Atrophy;Myopathy;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Physiological;Play;Proteins;receptor;Role;Signal Pathway;Signal Transduction;Signaling Protein;skeletal;Skeletal Muscle;skeletal muscle growth;Smad Proteins;System;TGF-beta type I receptor;Transforming Growth Factor beta;virtual

PROJECT_TITLE: Signaling mechanisms utilized by myostatin and related ligands in skeletal muscle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (05)]


ORG_DEPT: SURGERY

PHR: Narrative: This work will increase understanding of transcriptional regulation during mammalian digit tip regeneration and provide important perspective for comprehending, and perhaps changing, existing limitations in the regenerative capacity of human limbs.

PI_NAMEs: BROWN, DAVID ANDREW (contact);POSS, KENNETH D

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;adeno-associated viral vector;Adult;Amphibia;Amputation;Anatomy;appendage;Biological Assay;blastema;bone;Bone Regeneration;Capsid;Caring;Catalogs;Cells;Chromatin;Chromosomes;cofactor;Comparative Study;Complex;conditional knockout;Dependovirus;digit regeneration;Digit structure;Directed Molecular Evolution;Distal;DNA-Protein Interaction;Elements;Engineering;Epidermis;Event;Exhibits;Family;Gene Expression;gene therapy;Genes;Genetic Enhancer Element;Genetic Transcription;Goals;Growth;Hand;healing;Human;human tissue;Immunoprecipitation;Impairment;improved;in vivo evaluation;Injury;insight;intramembranous bone;Knockout Mice;limb loss;limb regeneration;Limb structure;Maps;Mass Spectrum Analysis;member;Methodology;Methods;Modeling;Molecular;Molecular Genetics;Mus;Names;Natural regeneration;novel;Organism;Pathway interactions;Patients;Phalanx;programs;promoter;regeneration potential;regenerative;Regenerative capacity;Regulatory Element;Reporter;Reporting;Salamander;Sampling;selective expression;Serotyping;Site;spatiotemporal;Specificity;teleost fish;Testing;tissue regeneration;tissue repair;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Variant;vector;Viral;Viral Genes;Visual;Work;Zebrafish

PROJECT_TITLE: Gene therapy methods for enhancing limb regeneration based on conserved transcriptional programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-A (50)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: ––– PROJECT NARRATIVE –––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Substance use disorders are a chronic human condition driven by numerous genetic factors. Many of these have remained opaque, and most human genes that have been linked with substance use phenotypes in genome-wide association studies have not been investigated for their causal roles. The results from this proposal will identify genes that affecting experience dependent amphetamine preference in vivo, thereby illuminating critical mechanisms driving addiction and substance use.

PI_NAMEs: ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acetylcholine;addiction;Affect;aged;alcohol response;Alcohols;Amphetamines;Automobile Driving;Award;behavioral study;Biological;Biological Assay;Biological Process;Brain;Candidate Disease Gene;Chromatin;Chromatin Structure;Chronic;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Databases;Deposition;Desire for food;Development;Dopamine;driving force;Drosophila genus;Drosophila melanogaster;drug of abuse;Economic Burden;endonuclease;endophenotype;Etiology;experience;experimental study;fly;Funding Agency;Future;gain of function;gamma-Aminobutyric Acid;Gene Expression;gene function;Generations;Genes;Genetic;genetic approach;genetic manipulation;Genetic Models;Genetic study;Genetic Transcription;Genome;genome wide association study;genome-wide;genome-wide analysis;Genotype;Glutamates;Goals;Guide RNA;Hour;Human;Human Genome;in vivo;insight;knock-down;Knock-out;Lead;Link;loss of function;Mediating;model organism;Molecular;molecular phenotype;mutant;National Institute of Drug Abuse;Nervous System;neuromechanism;neuron loss;Neurotransmitters;NIH Program Announcements;Norepinephrine;novel;Octopamine;Orthologous Gene;Overdose;overexpression;pandemic disease;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Phenotype;Positioning Attribute;preference;Prevalence;Process;psychostimulant;Public Health;Publishing;Resources;response;Rewards;RNA;RNA Interference;Role;Sampling;Self Administration;Serotonin;Signal Transduction;Single Nucleotide Polymorphism;Societies;stimulant use;substance use;Substance Use Disorder;Sucrose;System;Testing;Therapeutic;therapeutic target;Tissues;tool;Transcript;Transcriptional Activation Domain;Transgenic Organisms;Validation;Variant;vinegar fly

PROJECT_TITLE: Genetics of Amphetamine Preference

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (J1)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Claes-Jensen Syndrome is a rare neurodevelopmental disorder caused by variants in the X-linked gene KDM5C that encodes a histone modifying enzyme. With the goal of improving the lives of those affected by Claes-Jensen Syndrome, in May 2022, several families came together to form the KDM5C advocacy research education and support (KARES) foundation. This proposal seeks support for the first KARES Foundation family and science conference that will bring together stakeholders in understanding Claes-Jensen Syndrome, including caregivers and affected individuals, researchers, and clinicians.

PI_NAMEs: SECOMBE, JULIE  (contact)

PROGRAM_OFFICER_NAME: URV, TIINA K

PROJECT_TERMS: Advocacy;Affect;Aggressive behavior;Animal Model;Anxiety;associated symptom;Ataxia;autism spectrum disorder;Basic Science;Behavior;Biological Markers;Brain;Caregivers;Clinical;Clinical Research;Cognition;comorbidity;Data Collection;Development;diagnostic tool;Disease;Education;education research;Enrollment;Enzymes;Epilepsy;exome sequencing;experience;Facebook;Family;Family Study;family support;Financial Support;Foundations;Funding;Gene Expression;Genes;Genetic Transcription;genetic variant;Genotype;Goals;Grant;Heterozygote;Histones;Impaired cognition;Impairment;improved;Incidence;Individual;innovation;Intellectual functioning disability;International;Knowledge;Learning;Left;Life Experience;Link;loss of function;loved ones;Lysine;male;Mediating;meetings;Mission;Neurodevelopmental Disorder;Neurons;Pathogenicity;Patients;personalized medicine;Phenotype;Pilot Projects;Process;programs;Publications;Publishing;Quality of life;Rare Diseases;Registries;Research;Research Personnel;Research Priority;Research Project Grants;Role;Running;Science;Scientist;Seizures;Speech;Standardization;Study models;Support Groups;symposium;symptom treatment;Symptoms;Syndrome;targeted treatment;Texas;therapeutic development;Time;Update;Variant;virtual;women's outcomes;Work

PROJECT_TITLE: 2024 KARES Family and Science Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-2 (02)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE We propose to use infection of Indian rhesus macaques by glycan-deleted SHIVs to prime, boost and affinity- mature bNAb responses targeting the fusion peptide through a natural process of Env-Ab coevolution. Then, by deciphering molecular pathways of Env-Ab coevolution leading to neutralization breadth, we will develop a “molecular blueprint” for the design of a germline-targeted, lineage-based, all-SOSIP Env trimer immunization scheme to test in rhesus macaques, and if successful, in humans.

PI_NAMEs: SHAW, GEORGE M (contact)

PROGRAM_OFFICER_NAME: MILLER, NANCY R

PROJECT_TERMS: Affinity;Animal Model;Animals;Antibodies;Antibody Affinity;Antibody Response;Antibody-mediated protection;Antigens;Apical;Autologous;B-Lymphocytes;Binding;Binding Sites;Biological Models;CD4 Positive T Lymphocytes;Cell Lineage;Cells;design;Development;Dose;Epitope Mapping;Epitopes;Event;Frequencies;Germ Lines;glycosylation;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immunization;Infection;innovation;Knock-in Mouse;Knock-out;Link;Macaca;Macaca mulatta;Molecular;Monkeys;Mutation;neutralizing antibody;next generation;novel;Pathway interactions;Pattern;Peptides;Polysaccharides;pre-clinical;Process;Proteins;Rectum;Regimen;Reproducibility;Research Personnel;response;Reverse engineering;Rhesus;Scheme;Science;simian human immunodeficiency virus;Site;Structure;Testing;transmission process;Vaccination;vaccine candidate;vaccine development;vaccine discovery;vaccine evaluation;vaccine trial;Vaccines

PROJECT_TITLE: SHIV-guided design of novel HIV-1 fusion peptide immunogens

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Male infertility can result from abnormalities in the structure of proteins (chromatin) that package DNA within the nucleus (epigenetics). Proteins that modify chromatin alter histone-DNA contacts, disrupting DNA structure and gene expression. Genetic experiments that elucidate the specificity of these chromatin-modifying proteins may lead to targeted treatments.

PI_NAMEs: MAGNUSON, TERRY R (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Award;Binding Proteins;Budgets;Cell Nucleus;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosomes;Complex;cost;Development;Direct Costs;Disease;DNA;DNA Double Strand Break;DNA Packaging;DNA Repair;DNA Structure;Enzymes;epigenetic memory;Epigenetic Process;epigenetic regulation;equipment acquisition;Experimental Genetics;experimental study;Funding;Gametogenesis;Gene Expression;Gene Expression Regulation;gene repression;Genetic Recombination;Germ Cells;Grant;histone modification;Histones;Infertility;interest;male;Male Infertility;Meiosis;mouse development;Parents;Post-Translational Protein Processing;programs;protein structure;Proteins;recruit;Research;Retirement;Series;Sex Chromosomes;Somatic Cell;Specificity;sperm cell;Spermatogenesis;Time;Transcriptional Regulation

PROJECT_TITLE: Albino Deletion Complex and Early Mouse Development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Alzheimer’s disease and related dementias (ADRD) are prevalent, afflicting more than 50 million Americans directly and countless additional family members and caregivers, and devastating. Understanding the relationship between/mechanisms underlying posttraumatic neurodegeneration is critical to diagnosing and treating afflicted patients more effectively. NEW-HOPE-TBI will develop and enhance a world-class brain tissue and open-access digital resource that combines deep clinical phenotyping, advanced neuroimaging, and state-of-the-art multimodal neuropathology from diverse prospective and observational cohorts across the spectrum of TBI-exposed and unexposed AD and ADRD donors to propel impactful posttraumatic AD and ADRD research.

PI_NAMEs: KEENE, CHRISTOPHER DIRK (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;arteriole;Autopsy;Behavioral;behavioral health;biobank;Bioethics;Biological Markers;Blood Vessels;Brain;brain based;Brain region;brain tissue;burden of illness;career development;Cessation of life;Characteristics;Chronic;chronic traumatic encephalopathy;Clinical;Clinical Data;clinical phenotype;Cognitive;Cognitive deficits;cohort;Cohort Studies;Collaborations;Collection;Common Data Element;Communities;comorbidity;connectome;Coupled;Craniocerebral Trauma;Data;data resource;data sharing;Dementia;density;Deposition;Development;Diagnosis;diagnostic strategy;Diffusion Magnetic Resonance Imaging;digital;digital imaging;digital pathology;dimensional analysis;Disease;Disease Progression;endophenotype;Ensure;equity, diversity, and inclusion;Etiology;executive function;Family Caregiver;Family member;Frequencies;Funding;Future;Goals;head impact;high dimensionality;Image;image archival system;image guided;Impaired cognition;in vivo;in vivo evaluation;in-vivo diagnostics;Individual;Injury;innovation;Investments;Knowledge;Late Effects;Lead;Life;Link;Lived experience;loved ones;Magnetic Resonance Imaging;marginalized population;Measures;Medical Examiners;Metadata;Methods;Microscopic;Modeling;MRI Scans;multimodality;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Network-based;neurobehavioral;Neurodegenerative Disorders;neuroethics;neuroimaging;neuropathology;New York;next generation;novel;open data;Outcome;Pacific Northwest;Pathologic;Pathologic Processes;Pathology;pathology imaging;Patients;Pattern;Penetration;Peptides;Persons;Phenotype;Plasma;Positioning Attribute;preservation;prevent;prospective;Protein Isoforms;Proteomics;Protocols documentation;Recommendation;Recording of previous events;Registries;Research;Research Infrastructure;Research Personnel;Research Support;Resolution;Resources;response;Risk;Sampling;Scanning;Science;Scientist;Services;Severities;social health determinants;symposium;Symptoms;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;Tissue Sample;Tissues;trauma exposure;Traumatic Brain Injury;Underrepresented Populations;United States National Institutes of Health;Universities;vascular injury;Washington;Work

PROJECT_TITLE: Neuroimaging and clinical Endpoints With High-dimensional analysis Of Pathological Endophenotypes in TBI (NEW-HOPE-TBI)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Immunotherapy and targeted therapy have arguably been the most important recent advances in treatment for colorectal cancer (CRC), but such advances have not equally benefited all individuals. Our goal is to identify and characterize the underexplored, critically important molecular mechanism of RNA splicing in CRC among patients of different races, ethnicities and ancestries and its influence on outcomes and disparities across these populations. To do this, we will use preclinical CRC models and leverage existing diverse cohorts with biospecimens and annotated data including the Latino Colorectal Cancer Consortium (LC3), the Detroit Research on Cancer Survivors (ROCS), and The Cancer Genome Atlas (TCGA).

PI_NAMEs: FIGUEIREDO, JANE C. (contact);FREEDMAN, JENNIFER ANN;SCHMIT, STEPHANIE L.

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Accounting;African;African American;Alternative Splicing;Antigen Presentation;Apoptosis;Automobile Driving;Awareness;Biological Factors;BRAF gene;Cancer Biology;cancer cell;Cancer Etiology;cancer genetics;cancer health disparity;Cancer Model;cancer survival;Cancer Survivor;candidate identification;Caring;Cells;Cellular biology;Cessation of life;Characteristics;cohort;colon cancer cell line;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;Communities;Consensus;Controlled Study;CRISPR/Cas technology;Critiques;Data;Development;Disparity;Elements;Equity;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;Event;Exhibits;experience;FDA approved;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;Genetic Transcription;Genome;genome editing;Goals;Health;Hispanic;Immune;Immune checkpoint inhibitor;Immune response;immunogenic;Immunooncology;Immunotherapy;In Vitro;in vivo;Individual;Induction of Apoptosis;Inequity;Intervention;Invaded;Knowledge;KRAS2 gene;Latina;Latino;Latinx;lifestyle factors;Location;Malignant Neoplasms;Mediating;Messenger RNA;Methodology;Microsatellite Instability;Microsatellite Repeats;migration;Minority Groups;Molecular;molecular subtypes;Molecular Target;mouse model;Mutate;Mutation;neoantigens;Neoplasm Metastasis;Not Hispanic or Latino;novel;Observational Study;Outcome;Participant;Pathogenicity;Patient Self-Report;Patients;Pattern;Population;Population Heterogeneity;pre-clinical;precision medicine;precision oncology;Process;Prognosis;prognostic indicator;Proliferating;Protein Isoforms;Proteins;Puerto Rican;Race;racial diversity;racial minority population;racial population;randomized trial;Research;Resources;response;RNA Splicing;Role;social;Somatic Mutation;Spliceosomes;targeted treatment;The Cancer Genome Atlas;therapeutic target;Transcript;transcriptome;transcriptomics;Translational Research;treatment disparity;Treatment outcome;treatment response;tumor;tumor growth;Tumor Immunity;tumor-immune system interactions;Underrepresented Populations;Variant;Viral;Work

PROJECT_TITLE: Elucidating the role of transcriptomics in driving ethnicity and ancestry-related disparities in colorectal cancer


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Despite considerable efforts to reduce oral health disparities, poor oral health continues to disproportionately affect Black and Hispanic children. The proposed research will investigate the influence of race/ethnicity on progression of dental caries and identify modifiable structural risk factors of disparities in quality of dental care to assess the cost-effectiveness and value of dental care, incorporating racial/ethnic disparities in the assessment of value. The results of this project are expected to inform multilevel interventions and support evidence-based policymaking by identifying strategies resulting in high-value care that also address equity.

PI_NAMEs: CHOI, SUNG EUN  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: access disparities;Address;Adolescent;advanced analytics;Affect;Age;Alabama;analytical method;Area;Arkansas;Behavior;beneficiary;Black American;Black race;career;career development;Caring;Characteristics;Child;Child Health;Childhood;Chronic Disease;Colorado;Communities;Connecticut;contextual factors;cost;Cost Analysis;cost effective;cost effectiveness;Cost of Illness;cost outcomes;County;Data;Data Set;Decision Making;Dental;Dental Care;Dental caries;Dental Epidemiology;Dental Hygiene;Dental Insurance;Dentists;Development Plans;dietary;Disease Outcome;Disease Progression;Disparity;disparity reduction;Electronic Health Record;Equity;ethnic disparity;Ethnic Origin;evidence base;experience;Gender;Goals;Health;health assessment;Health behavior;Health Benefit;Health Disparities Research;health disparity;Health Insurance;Health Policy;Healthcare;Heterogeneity;high risk;Hispanic;Hispanic Americans;Improve Access;improved;Incidence;Individual;Interdisciplinary Study;Intervention;Learning;Machine Learning;mathematical model;Measures;Medicaid;Mentorship;Minority Groups;Modeling;models and simulation;modifiable risk;Mouth Diseases;multiple data sources;neglect;North Carolina;novel strategies;Oklahoma;Oral health;Outcome;Policies;Policy Maker;Policy Making;Predictive Analytics;Process Measure;programs;Provider;public health insurance;public health intervention;Quality Indicator;Quality of Care;Quality of life;Race;racial disparity;racial population;Recommendation;Recording of previous events;Research;Resource Allocation;response;Risk;Risk Factors;risk prediction model;Schools;Science;skills;Statistical Models;stem;structural determinants;Survival Analysis;System;systemic barrier;Techniques;Testing;theories;Training;Training Programs;treatment effect;trend;Underserved Population;Vulnerable Populations;Work

PROJECT_TITLE: Reducing oral health disparities in children using predictive analytics and mathematical modeling


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: PROJECT NARRATIVE The “Building a Cancer Epidemiology Cohort to Investigate Factors Associated with Higher Risk of Colorectal Cancer among Alaska Native People” will establish the first cohort study of risk factors for colorectal cancer (CRC) among Alaska Native (AN) people and establish a rich biorepository for future CRC research. The study will collect dietary and lifestyle, anthropometric, sleep, and physical activity data and biospecimens from 1,000 AN people. Our goal is to establish a comprehensive, community-based cohort to investigate risk factors for CRC among AN people that will be used to inform primary prevention strategies in this high risk population that has the highest documented burden of CRC globally.

PI_NAMEs: REDWOOD, DIANA  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Adult;Alaska Native;Alaska Native population;anti-cancer research;Antibiotics;Antioxidants;Berry;biobank;Biological Markers;Biological Specimen Banks;Bioperiodicity;Biopsy;Blood;Cancer Center;Cancer Control;cancer epidemiology;cancer genetics;cancer health disparity;cancer prevention;cancer risk;Circadian desynchrony;Circadian Rhythms;Clinical;clinical decision-making;clinically actionable;cohort;Cohort Studies;Collaborations;Collection;Colon;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Colorectal Neoplasms;Communities;community based participatory research;Community Health;Data;Death Rate;demographics;design;Development;Diet;dietary;Dimensions;Disease;disorder risk;Disparity;Eating;Enrollment;Environmental Exposure;Epidemiology;epidemiology study;Epigenetic Process;Etiology;experience;extreme weather;Fishes;Food;fungus;Future;Genetic;genetic profiling;Genetic Research;genome sequencing;Goals;Hair;health disparity populations;Helicobacter Infections;High grade dysplasia;high risk;high risk population;holistic approach;Hospitals;improved;Incidence;Individual;insight;Institutional Review Boards;interest;intersectionality;Investigation;iq'mik;Leadership;Life Style;lifestyle factors;Malignant Neoplasms;Mammals;Measures;Medical History;Medical Records;Methods;microbiome;microbiome analysis;Molecular;Molecular Analysis;Molecular Profiling;Morbidity - disease rate;mortality;multi-ethnic;Mutation;Nitrosamines;novel;Occupations;Oral Tobacco;Outcome;Participant;Patients;Pharmaceutical Preparations;Phase;Physical activity;Polyps;Polyunsaturated Fatty Acids;Population;Preparation;Prevention approach;Prevention strategy;preventive intervention;Primary Prevention;Process;programs;prospective;Prospective cohort;Prospective, cohort study;protective factors;Protocols documentation;Proton Pump Inhibitors;Questionnaires;recruit;Research;Research Infrastructure;Resources;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;Rural;Saliva;Sampling;screening;Sea;Secondary Prevention;Serrated Adenoma;Sleep;Smoking;Statistical Data Interpretation;Testing;Time;Tobacco;Tobacco use;translational potential;tribal health;Tribes;tumor;Tumor Tissue;Urine;Villous;Visit;whole genome;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (J1)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Despite unsafe firearm storage being the leading cause of firearm-related injury/death among young children (under age 5 years), we lack information regarding how to develop and deliver effective messaging to encourage parents to adopt firearm safety practices in early childhood. This study will employ a mixed methods, community-based, developmentally-informed approach to improve our understanding of the scope of and motivations for gun ownership, storage, and use among parents with young children. Applying decision science and behavioral economics constructs, and in concert with community partners, we will assess parents’ mental models of firearm safety and injury prevention during early childhood and apply the lessons learned to develop a parent-engaged intervention delivered by trusted messengers and precision messaging tailored for firearm injury prevention in early childhood.

PI_NAMEs: HSIEH, HSING-FANG ;MILLER, ALISON L (contact)

PROJECT_TITLE: RFA-CE-23-005, Firearm safety and injury prevention during early childhood: A parent engagement approach


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Seasonal influenza (flu) infections kill hundreds of thousands of people each year and, while the annual flu vaccine is an important line of defense against this virus, we need to improve the vaccine to make it more effective. Before we can do this, we must first better understand the immune cells that respond to the vaccine. The goal of this proposal is to develop the tools and animal model systems to systematically and comprehensively study the flu-specific memory B cells that are the direct target of flu vaccination in adults.

PI_NAMEs: LUND, FRANCES E. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adult;Animal Model;Antibodies;Antibody Response;Antibody-Producing Cells;Antigens;antiviral immunity;B-Lymphocyte Subsets;B-Lymphocytes;Biological Models;Blood;cell type;Cells;Clinical;cohort;Complex;cross reactivity;Data;Death Rate;design;Development;emerging virus;experimental study;Exposure to;flu;Flu virus;Future;Goals;Healthcare;Human;human tissue;Immune;Immune response;Immunity;Immunoglobulin-Secreting Cells;imprint;improved;Individual;Infection;Inflammation;Influenza;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus vaccine;insight;Knowledge;Life;life span;Link;Lung;Lymphoid;Lymphoid Tissue;Mediator;Memory;Memory B-Lymphocyte;Morbidity - disease rate;mortality;Mucous Membrane;Mus;new pandemic;novel vaccines;pandemic disease;Persons;Population;Population Heterogeneity;Predictive Value;pressure;prevent;Public Health;Reaction;respiratory;response;seasonal influenza;Seasons;Signal Transduction;Specificity;Structure of germinal center of lymph node;T memory cell;T-bet protein;Testing;Time;Tissues;tool;Vaccination;vaccine efficacy;vaccine immunogenicity;vaccine response;Vaccines;Viral;Virus

PROJECT_TITLE: Identification and characterization of effector memory B cell populations that dominate memory responses to subsequent influenza infection and vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(90)R]


ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative – Overall Program Dana-Farber Cancer Institute This program will help develop minimal residual disease (MRD)-based therapeutics and will investigate whether MRD negativity should be the ultimate goal of therapy. Moreover, the oncogenomic studies will both identify genomic and epigenomic correlates of disease behavior, and clonal evolution and develop new risk stratification model as well as identify novel targets.

PI_NAMEs: MUNSHI, NIKHIL C. (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Affect;Algorithms;Architecture;Automobile Driving;Basic Science;Behavior;bench to bedside;Biochemical;Bioinformatics;Biological;Biology;Biometry;bone cell;Bone Marrow;cancer genomics;Cell Communication;cell growth;Cells;Cessation of life;Chromatin;Chronology;Clinical;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;clinically relevant;Clonal Evolution;cohort;Collaborations;collaborative trial;Communication;Dana-Farber Cancer Institute;Data;data and analysis portal;Dependence;Disease;Disease Outcome;Disease Progression;DNA Sequencing Facility;Dose;drug resistance development;Environment;Epigenetic Process;epigenomics;Funding;Genetic Transcription;Genomic Instability;Genomics;Goals;Immune;improved;Individual;inhibitor;International;Interruption;Maintenance;malignant phenotype;Mediator;Modeling;Molecular;Multiple Myeloma;Mutation;new therapeutic target;Newly Diagnosed;next generation;novel;novel therapeutic intervention;novel therapeutics;Patient-Focused Outcomes;Patients;Pattern;Physical condensation;pre-clinical;Process;Prognosis;Program Research Project Grants;programs;Randomized;relapse patients;Research Personnel;Residual Neoplasm;Resistance;Risk;risk stratification;Role;Sampling;sequencing platform;Signal Transduction;small molecule inhibitor;stem;STING agonists;Stromal Cells;survival outcome;Talents;targeted sequencing;targeted treatment;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;Translations;Transplantation;United States;Untranslated RNA

PROJECT_TITLE: Integrative Oncogenomics of Multiple Myeloma