NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The PKA catalytic subunit serves as a structural prototype for the protein kinase superfamily, while the diverse functionally non-redundant holoenzymes serve as a model for dynamic allosteric regulation by a second messenger. In parallel with characterizing macromolecular polyvalent PKA signaling complexes, we will use our interdisciplinary tools to characterize previously unstudied Cβ isoforms that are highly expressed in neurons, including pathogenic Cβ mutants, as well as mutants of RIβ, that are also highly expressed in neurons, that form novel biomolecular condensates in cells, and that are associated with dementia.

PI_NAMEs: TAYLOR, SUSAN S. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Achievement;Active Sites;Allosteric Regulation;autism spectrum disorder;Biochemical;Biochemistry;Biology;Biophysics;Buffers;C-terminal;career;Catalytic Domain;Cells;Complex;Cryoelectron Microscopy;Crystallography;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dedications;Dementia;Disease;Family;frontier;G-Protein-Coupled Receptors;Goals;Golgi Apparatus;high resolution imaging;Holoenzymes;Human;human tissue;Image;Label;Laboratories;Learning;Length;Link;Liquid substance;Mediating;Mitochondria;Modeling;Molecular Biology;Molecular Conformation;molecular dynamics;mutant;Mutation;National Institute of General Medical Sciences;neurodegenerative phenotype;Neurons;novel;Pathogenicity;Phase;Physical condensation;Productivity;Protein Isoforms;Protein Kinase;prototype;Recording of previous events;Retina;RNA Splicing;Second Messenger Systems;SHH gene;Signal Transduction;Site;smoothened signaling pathway;Structure;Tail;Time;Tissue imaging;tool;Variant;Visualization;Work

PROJECT_TITLE: Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  The fundamental premise of this training program is that early engagement of computationally strong students, principally engineers, in understanding fundamental mechanisms of neuroscience will accelerate development of technology and solutions for the diagnosis and treatment of stroke, Parkinson’s disease, amyotrophic lateral sclerosis, traumatic brain injury, pain, epilepsy, paralysis, and other neurodegenerative disorders. Graduates of this novel training program will have the knowledge and expertise to pursue either an academic research career and/or a private sector research career in neurotechnology.

PI_NAMEs: MORAN, DANIEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Translational Neuroscience and Neurotechnology Training (TNNT)


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: In accordance with NINDS scientific goals to “understand the basic mechanisms of neurological disorders”, and “to discover and validate biomarkers and outcome measures”, the proposed work will advance the understanding of the neurobiological basis for poststroke spasticity and provide quantitative neuroimaging biomarkers to be used as outcome measures in clinical trials. This research will solve an urgent public health need to provide a more complete understanding of the neural mechanisms of poststroke spasticity by characterizing the functions of major descending and ascending circuits in relation to spastic hypertonia and hyperreflexia.

PI_NAMEs: VAHDAT, SHAHABEDDIN  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Anterolateral;biomarker validation;Biomechanics;Brain;Brain imaging;Chronic;Clinical Management;Clinical Trials;Contracture;Contralateral;Data;Dorsal;dorsal column;dorsal horn;Early Diagnosis;effective therapy;Electromyography;Electrophysiology (science);Felis catus;Fiber;Flexor;follow-up;Functional Magnetic Resonance Imaging;Goals;grasp;Hand;Hand functions;Handedness;heat stimulus;Hemiplegia;Human;Hyperactivity;Hyperreflexia;Impairment;Ipsilateral;Knowledge;Lead;Lesion;Manuals;Measurement;Measures;Medial;Mental Depression;Methods;Modeling;Motor;motor impairment;Motor Neurons;Motor Pathways;Movement;Muscle;Muscle Hypertonia;Muscle Tonus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;neural model;Neurobiology;neuroimaging;neuroimaging marker;neuromechanism;Noise;Outcome Measure;Pain;Pathway interactions;Peripheral;Play;post stroke;preclinical study;Primates;Prognosis;Prognostic Factor;Protocols documentation;Public Health;Recovery of Function;Reflex action;Research;Resistance;Resolution;response;reticulospinal tract;Role;Sensory;Signal Transduction;somatosensory;spasticity;Spinal;Spinal Cord;spinal pathway;Stimulus;stretch reflex;Stretching;stroke patient;stroke survivor;Symptoms;Testing;Theoretical model;Torque;Translating;Upper Extremity;Work;Wrist

PROJECT_TITLE: The function of descending and ascending pathways in spastic hypertonia and hyperreflexia after stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: KUMASI

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH

PHR: NARRATIVE This study seeks to establish a registry with a cohort of 6,000 individuals living with Sickle Cell Disease (SCD) across the lifespan with a dual purpose of understanding the determinants of the manifold acute and chronic complications of this common genetic disease. We will develop guidelines to improve the clinical care of patients living with SCD receiving healthcare at various levels of care delivery in Ghana. We will work collaboratively with the Clinical Coordinating Center of SPARCO to conduct three cohort studies, three implementation research studies and store patient-consented bio- specimens for future studies in a bid to establish the necessary infrastructure to develop a SCD in sub-Saharan Africa Research Network.

PI_NAMEs: OFORI-ACQUAH, SOLOMON FIIFI;SARFO, FRED STEPHEN (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Abnormal Hemoglobins;Acute;Address;Adolescence;Adolescent;Adoption;Adult;Advocacy;Affect;Africa;Africa South of the Sahara;African;Agreement;Analgesics;Area;Benchmarking;Blood Transfusion;Capital;care delivery;Caring;cell registry;Cephalic;Cessation of life;Child;Chronic;Cities;Clinic;Clinical;clinical care;Coagulation Process;cohort;Cohort Studies;Consent;Country;Data;Death Rate;Decision Making;Disease;Disease Management;Electronics;Endothelium;Enrollment;Erythrocytes;Ethics;Etiology;Event;evidence base;feasibility testing;functional status;Future;Genes;Genetic Diseases;Genotype;Ghana;Goals;Grant;Guidelines;Harvest;Health Policy;Healthcare;Hematology;Hemoglobin;Hemolytic Anemia;Hereditary Disease;Hospitals;Hydration status;hydroxyurea;Impaired cognition;implementation facilitators;implementation research;implementation strategy;implementation study;improved;Incidence;Individual;Infection;Infection prevention;Infrastructure;Intervention;Kidney;Kidney Diseases;Laboratories;life span;Managed Care;Medical center;mhealth interventions;Morbidity - disease rate;Neonatal Screening;Neurologic;neurovascular;Nigeria;Online Systems;Ontology;Organ;Outcome;oxidant stress;Patient Care;patient registry;Patients;Penicillins;Pharmaceutical Preparations;Phase;Phenotype;Pneumococcal vaccine;point of care testing;Policies;Prenatal Diagnosis;preventive intervention;programs;prophylactic;Prophylactic treatment;prospective;Prospective cohort;Proteinuria;Protocols documentation;Quality of life;Recommendation;recruit;Recurrence;Registries;Renin-Angiotensin-Aldosterone System;Research;research study;Resource-limited setting;Resources;screening;screening program;Sickle Cell;Sickle Cell Anemia;sickling;Site;sociodemographics;Standardization;statistics;Stroke;Structure;Syndrome;System;systemic inflammatory response;Tanzania;Training;Transfusion;Vascular Endothelium;Vision;Work

PROJECT_TITLE: Ghana-SPARCO: Ghana Sickle Pan-African Research Consortium


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The UCSF Molecular Biophysics program trains talented, creative, and diverse students to apply physical and quantitative approaches to solve the most challenging problems in biology and human health. Graduates are equipped with the required technical, operational, and professional skills to become the next generation of leaders in academics, industry and beyond.

PI_NAMEs: MANGLIK, AASHISH  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biophysics;Grant;Molecular;Training

PROJECT_TITLE: Molecular Biophysics Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Metabolic diseases, including diabetes mellitus and obesity, are major public health concerns in the US and worldwide. The objective of this Training Program is to recruit, mentor, and train a talented and diverse cadre of scientists to carry out cutting-edge basic science and translational research focused on improving the health of individuals with or at risk of type 1 and type 2 diabetes, obesity, and their associated complications. This program will leverage the infrastructure, resources, and rich training environment of the Indiana University School of Medicine and the Indiana Diabetes Research Center to nurture the careers of the next generation of diabetes, obesity, and metabolism investigators.

PI_NAMEs: EVANS-MOLINA, CARMELLA ;WEK, RONALD C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Diabetes and Obesity Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

ORG_STATE: IL

PHR: NARRATIVE There are a variety of motor deficits following stroke which present growing challenges to healthcare. Therapeutic practice with physical devices remains an exciting frontier for the recovery of function, but a critical question is precisely how such devices should be programmed. Here we investigate differences in outcomes using models that describe how a person responds to error during practice, and we evaluate how well these models can prescribe the best therapeutic training.

PI_NAMEs: PATTON, JAMES LANPHIER (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Agreement;Basic Science;Clinical;clinical application;clinical training;Clinical Trials;Communication;Complex;Computer Models;computer science;Computers;Data;Descriptor;Development;Devices;Diagnosis;effective therapy;effectiveness testing;efficacy evaluation;Engineering;Environment;experience;experimental study;Feedback;force feedback;Freedom;frontier;functional restoration;Goals;haptics;Healthcare;hemiparetic stroke;improved;Individual;innovation;Investigation;Knowledge;Learning;mathematical model;Methods;Modality;Modeling;Motor;motor deficit;motor learning;motor recovery;Motor Skills;Movement;neurological rehabilitation;Neuronal Plasticity;Outcome;Pathway interactions;Patients;Persons;Population;post stroke;Process;randomized, clinical trials;Recovery;Recovery of Function;Research;response;Robot;Robotics;Role;Sensory;Source;Stroke;stroke survivor;success;System;Techniques;Technology;Testing;Therapeutic;therapy design;tool;Touch sensation;Training;Transference;trend;User-Computer Interface;Variant;virtual;Vision;Visual;visual feedback;Work

PROJECT_TITLE: Error-enhanced Learning & Recovery in 2 & 3 Dimensions


NIH_SPENDING_CATS: Hematology

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Advanced research training of doctors and scientists in hematology is essential to finding cures for blood diseases. This training program will prepare a diverse group of hematologists and scientists to develop new scientifically based treatments and understandings of these diseases to improve the health and safety of patients with blood diseases and eliminate health disparities.

PI_NAMEs: MILLER, JEFFREY S.;VERCELLOTTI, GREGORY M (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Hematology Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Bethesda

ORG_NAME: ASSOCIATION /PUBLIC HEALTH LABORATORIES

ORG_STATE: MD

PHR: Project Narrative The purpose of this proposal from the Association of Public Health Laboratories (APHL), submitted in partnership with the Association of Food and Drug Officials, the National Environmental Health Associatoin and the International Food Protection Training Institute, is to continue building competency-based, comprehensive and integrated training for regulatory laboratory scientists. APHL will adhere to the standards set by the National Curriculum Standard and work with FDA to employ an industry-accepted instructional design process to deliver effective and focused courses. The outcome will be a cadre of human and animal food testing laboratorians with standardized competence in their discipline, thereby facilitating long-term improvements to the national food safety system.

PI_NAMEs: SHEA, SHARI  (contact)

PROGRAM_OFFICER_NAME: WERNICK, MARC

PROJECT_TITLE: FDA's National Curriculum Standard Development and Training Delivery and Development (U18)


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS STATE DEPARTMENT OF HEALTH

ORG_STATE: AR

PHR: The Arkansas Public Health Laboratory (APHL) at the Arkansas Department of Health (ADH) has been an active member of the Food and Drug Administration’s (FDA) Food Emergency Response Network (FERN) since 2009. The APHL proposes to continue its participation as a part of the chemistry cooperative agreement by providing readiness in support of food defense, surveillance of food commodities and increasing capability and capacity through the application of new methodologies. Without funding from this cooperative agreement, the APHL will not be able to be part of the FDA integrated food safety system.

PI_NAMEs: BAILEY, LAURA ;SEELY, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Increasing capability and capacity in an integrated food safety collaboration


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Coordination of the cellular transcriptional program is central to all processes of life, including growth and differentiation as well as response to environmental cues. Emerging evidence suggests a primary role for coding and non-coding RNAs in mediating this response through direct interaction with transcription factors. Uncovering the mechanisms of action of this layer of regulation promises to reveal fundamental processes driving the transcriptional response as well as uncover new therapeutic targets.

PI_NAMEs: WUTTKE, DEBORAH S. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Abbreviations;Address;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological;Biology;Cell Physiology;Cells;Chromatin;Code;Collaborations;Complex;Consensus;Crystallization;Cues;Data;Data Set;Databases;design;Differentiation and Growth;DNA Binding;DNA Binding Domain;Double-Stranded RNA;Electrophoretic Mobility Shift Assay;Elements;embryonic stem cell;EMSA;Enhancers;Estrogen Receptors;Exhibits;experimental study;Family;Fingers;Fluorescence Anisotropy;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;genome-wide;Glucocorticoid Receptor;Glucocorticoids;Goals;Grant;HMGB Family Gene;Hormones;In Vitro;in vitro activity;in vivo;insight;Investigation;Life;Measures;Mediating;member;Modeling;Molecular;Molecular Conformation;Motivation;Mouse Embryonic Stem Cells;mutant;Nature;new therapeutic target;novel;Nuclear;Nuclear Hormone Receptors;Nucleic Acid Regulatory Sequences;nucleic acid structure;Play;pluripotency factor;Prevalence;Process;Program Description;programs;promoter;Promoter Regions;Proteins;receptor binding;Regulation;Reporting;Research;Resolution;response;Response Elements;RNA;RNA Binding;RNA Recognition Motif;Role;Site;Specificity;Structure;Testing;Thiouridine;transcription factor;Transcriptional Regulation;transcriptome;ultraviolet;Untranslated RNA

PROJECT_TITLE: RNA Regulation of Transcription Factor Activity

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_CITY: TRENTON

ORG_NAME: NEW JERSEY STATE DEPARTMENTR/AGRICULTURE

ORG_STATE: NJ

PHR: Project Narrative (Overall) The Laboratory Flexible Funding Model (LFFM) co-operative agreement program will provide equipment, supplies, personnel, and training in standardized testing methodologies as well as quality assurance. These provisions will enhance animal food sample collection, testing, and surveillance testing capabilities of the New Jersey Department of Agriculture (NJDA). The NJDA’s participation in the LFFM will help strengthen the nationwide integrated laboratory sciences and food safety in support of the Food Safety Modernization Act (FSMA).

PI_NAMEs: PATIL, AMAR  (contact)

PROJECT_TITLE: NJ Department of Agriculture, Animal Food Product Testing and Capability/Capacity Development for Integrated Food Safety


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative The proposed project is relevant to public health because it has the potential for developing therapeutic interventions for craniometaphyseal dysplasia (CMD), a lifelong debilitating craniotubular disease. The results and methods established in this project will also facilitate research on other rare genetic bone disorders (more than 500 identified) or more common bone diseases, like osteoporosis.

PI_NAMEs: CHEN, I-PING  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 1 year old;Acridine Orange;Actins;Age;Animal Model;Ankylosis;Autophagocytosis;Autophagosome;autosome;Binding;Biochemistry;Biological;Biological Markers;Biological Models;Biology;biomarker identification;Blindness;bone;bone cell;Bone Diseases;Bone remodeling;Bone Resorption;Breeding;Cell Shape;Cells;clinical care;Clinical Research;Connexin 43;cost;Craniofacial Abnormalities;craniofacial bone;Cytoskeleton;Data;deafness;Defect;Deformity;Deposition;differential expression;Disease;Disease Progression;Dissociation;Dysplasia;effective therapy;Endocrinology;Energy Metabolism;Event;Exhibits;Face;Facial paralysis;Fasting;Funding;Future;Genetic;genome editing;Glycolysis;Goals;Headache;Human;human induced pluripotent stem cells;Hyperostosis;Image;immunocytochemistry;improved;In Vitro;in vivo;inhibitor;insight;Investigation;Investigational Therapies;Knock-in Mouse;Knockout Mice;Knowledge;Life;Link;long bone;loss of function;Lysosomes;Membrane Fusion;Metabolic;Metabolic Bone Diseases;Metabolic Pathway;metabolomics;Methodology;Methods;Microfilaments;Microtubules;Molecular;Monitor;monomer;mouse model;Mus;mutant;Mutation;Neonatal;Neurologic Symptoms;novel;novel therapeutic intervention;Operative Surgical Procedures;Osteoclasts;Osteoporosis;Pathogenesis;Pathogenicity;Patient Care;Patients;Pharmacological Treatment;Phenotype;Phosphorylation;Plasma;Population;prevent;Property;Proteins;Protocols documentation;Proton Pump;Public Health;Publications;rare mendelian disorder;Regulation;Reporter;Research;response;Sampling;sensor;sex;Shapes;Signal Transduction;Skeletal Development;skeletal disorder;Spectrin;stem cell biology;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tool;translational study;Treatment Efficacy;Treatment Protocols;treatment response;Urine;vacuolar H+-ATPase;Vesicle;Western Blotting

PROJECT_TITLE: Pathogenic Mechanisms of Craniometaphyseal Dysplasia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE In this proposal the University of Pittsburgh School of Dental Medicine will establish a new Research Training Program aimed at preparing the next generation of Craniofacial/Dental focused scientists. Major research foci at Pitt Dental are Craniofacial/Dental Genetics and Craniofacial/Dental Tissue Regeneration as well as translational research. Trainees will be included at both the pre-doctoral and post-doctoral levels.

PI_NAMEs: SFEIR, CHARLES  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Admission activity;Artificial Intelligence;Award;Biomedical Engineering;Caliber;Clinic;Clinical Research;Clinical Sciences;craniofacial;Data Science;Dental;Dental Research;Dental Schools;Doctor of Philosophy;doctoral student;Ecosystem;education research;Engineering;Enrollment;experience;Faculty;Funding;Generations;Genetic Medicine;Goals;graduate school;Health Sciences;Human Genetics;Human Resources;Individual;Institution;International;Investments;Journals;Laboratories;Leadership;Medicine;Mentors;Methods;National Institute of Dental and Craniofacial Research;Oral;post-doctoral training;Postdoctoral Fellow;programs;Prosthodontic specialty;Public Health Schools;Regenerative Medicine;Reproducibility;Research;research faculty;Resources;responsible research conduct;Schools;Science;Scientist;Series;Students;symposium;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;University resources;Work

PROJECT_TITLE: Pittsburgh Craniofacial Sciences Training Program


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Lung;Nutrition

ORG_CITY: FORT COLLINS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Chronic exposures to environmental dusts lead to lung inflammation, injury, and disease. The overarching goal of our studies is to determine how dietary omega-3 fatty acids promote resolution and repair in the lung following dust exposure through regulating macrophage-derived IL-22 signaling. These studies support NIH goals by increasing our understanding of how particulate matter inhalation impacts lung inflammation, and exploring strategies for promoting recovery from these inflammatory exposures to protect against disease.

PI_NAMEs: NORDGREN, TARA M (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 3-Dimensional;Acids;Acute;aerosolized;Agriculture;Air;Air Pollution;Airway Disease;airway epithelium;airway inflammation;Alveolar;Alveolar Macrophages;Asthma;Attenuated;autocrine;Cells;Chronic;chronic inflammatory lung disease;chronic respiratory disease;Coculture Techniques;Data;desaturase;Diet;dietary;Disease;Disease Outcome;Docosahexaenoic Acids;Dust;Enzymes;epithelial repair;Epithelium;epithelium regeneration;evidence base;Exhibits;Exposure to;Farming environment;Fatty acid glycerol esters;Gene Expression Profiling;Genetic;Goals;Health;Immune;Immune signaling;Immunity;improved;in vivo;Inflammation;Inflammatory;Inhalation;Inhalation Exposure;injured airway;Injury;Intake;interleukin-22;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Leukotrienes;Link;lipid mediator;Lipids;Liquid substance;Lung;Lung Diseases;lung health;Lymphocyte;Macrophage;Macrophage Activation;Mediating;Mediator;Modeling;Molecular;Mucosal Immunity;Mus;nano-string;novel;novel therapeutic intervention;Omega-3 Fatty Acids;paracrine;Particulate;Particulate Matter;Pathway interactions;pharmacologic;Physiological;Pneumococcal Infections;Population;Predisposition;prevent;Production;Prostaglandins;protective effect;Publishing;pulmonary function decline;Pulmonary Inflammation;receptor;Receptor Signaling;Recommendation;Recovery;Regulation;repaired;Reporter;Research;resilience;Resolution;Respiratory Tract Infections;Risk;Role;rural environment;scaffold;Sepsis;Signal Transduction;Smoke;Source;STAT3 gene;Testing;Time;tissue repair;Tissues;Transgenic Mice;Translations;treatment strategy;United States National Institutes of Health;urban setting;western diet;Wildfire;YM1 doxorubicin analog

PROJECT_TITLE: Omega-3 fatty acids induce macrophage IL-22 signaling to promote resolution of dust-induced lung inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Narrative People living with HIV have comparable life-expectancy as their HIV-negative peers but their life-quality is deeply compromised due to the high prevalence of neuropsychiatric disorders. Cocaine abuse could exacerbate the existing neurological disorders in PLWHIV. Understanding the detailed mechanisms for the combined effects of HIV/HIV-TAT, antiretroviral and cocaine on microglial activation and neuronal injuries could give us clues to develop effective therapeutics and interventions for those people.

PI_NAMEs: GUO, MINGLEI  (contact);KIM, WOONG-KI

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: abuse victim;Adult;Affect;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;Archives;Autopsy;Behavior;Behavioral;Biological Response Modifiers;Brain;Brain region;brain tissue;Cell Nucleus;Chronic;clinical practice;Cocaine;Cocaine Abuse;cocaine self-administration;cocaine use;Coculture Techniques;comorbidity;Data;density;DLG4 gene;Doxycycline;Drug abuse;drug of abuse;emtricitabine;Excision;experimental study;Functional disorder;Genetic Transcription;glial activation;glial cell development;Glutamate Receptor;High Prevalence;HIV;HIV Infections;HIV Seronegativity;Human;IL18 gene;Immune response;In Vitro;in vivo;Incidence;Individual;Inflammasome;Inflammatory;inhibitor;Interleukin-1 beta;Intervention;Label;Life Expectancy;Lysosomes;Macaca;marenostrin;Mediating;Mental Depression;Microglia;Morphology;Mus;N-Methylaspartate;Nervous System Disorder;Neurologic;Neuronal Injury;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;neurotoxicity;NF-kappa B;Pathologic;Pathway interactions;peer;Persons;Population;Prevalence;Process;Production;Proteins;Quality of life;Regulation;Risk Factors;Role;Signal Transduction;SIV;System;Tenofovir;Testing;Therapeutic Effect;therapeutically effective;TLR4 gene;Trans-Activators;Transcription Coactivator;Vertebral column

PROJECT_TITLE: Role of the NLRP3 Inflammasome in Mediating Microglial Activation and Development of Neuropsychiatric Symptoms Induced by HIV, Antiretrovirals and Cocaine


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Transgender and other gender minority youth (TGMY) experience high rates of psychosocial (e.g., depression, teen dating violence) and behavioral health (e.g., substance use) problems, which are rooted in experiences of gender-related minority stress (e.g., peer and family rejection, internalized transphobia). This project aims to complete feasibility and pilot testing of a synchronous, group-delivered eHealth mentoring and skill-building program (i.e., Teen Connection Project) for TGMY ages 14 to 17 that focuses on evidence-based skill-building components (e.g., social-emotional skills) designed to reduce psychosocial and behavioral health problems in this population. The proposed project aligns with NIMHD’s research priorities to advance the scientific understanding of health disparities and improve minority health as well as the NIH Strategic Plan to Advance Research on the Health and Well-Being of Sexual and Gender Minorities (2021-2025).

PI_NAMEs: SWEARER, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Adult;adverse outcome;Age;Alcohol consumption;Authorization documentation;Baseline Surveys;behavioral health;children of color;community organizations;Data;Decision Making;design;Development;Drug usage;eHealth;Emotional;Evaluation;evidence base;experience;Face;Family;feasibility testing;Feedback;follow-up;Fostering;Gender;gender minority stress;gender minority youth;Goals;Health;health disparity;improve minority health;innovation;interest;Intervention;Interview;Lead;Lesbian Gay Bisexual Transgender Queer;Mental Depression;Mental Health;Mentors;Methodology;Methods;minority stress;National Institute on Minority Health and Health Disparities;Outcome;peer;Personal Satisfaction;Persons;Phase;pilot test;pilot trial;Population;positive youth development;prevent;Prevention;Procedures;Process;Program Development;Program Evaluation;programs;psychosocial;Randomized;recruit;Research;Research Personnel;Research Priority;rural area;Sampling;Scientific Advances and Accomplishments;Self Management;Self Perception;Self-Injurious Behavior;Sexual and Gender Minorities;sexual minority youth;sexual risk taking;Site;skill acquisition;skills;social;social emotional learning;Social Identification;social media;social stigma;Strategic Planning;substance use;Surveys;System;Teen Dating Violence;Teenagers;theories;Time;transgender;transphobia;United States;United States National Institutes of Health;violence perpetration;violence victimization;Waiting Lists;Youth

PROJECT_TITLE: Development and Pilot Evaluation of an Online Mentoring Program to Prevent Adversities Among Trans and Other Gender Minority Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: An excessive inflammatory response is associated with uncontrolled local and systemic inflammation during severe gram-negative bacterial infections, resulting in cell death and tissue damage. These studies will be the first to elucidate a pro-inflammatory role of inducible immunoproteasome structural assembly in gram-negative bacterial infection-induced acute inflammatory response. These studies will be critical in development of novel therapeutics by inhibition of USP14 or the immunoproteasome to diminish pro-inflammatory responses in acute respiratory distress syndrome (ARDS) and other lethal systemic inflammatory diseases.

PI_NAMEs: ZHAO, JING  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: 26S proteasome;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Animal Model;Antibiotic Resistance;Antigen Presentation;Attenuated;Bacteremia;Bacteria;Bacterial Infections;Bacterial Pneumonia;Blood specimen;Cell Death;Cell model;Complex;Complication;Data;Development;Disease;Down-Regulation;Endotoxins;Foundations;Functional disorder;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Homeostasis;Human;Immune response;Immune system;Incidence;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Lipopolysaccharides;Lung;lung injury;Maintenance;Malignant Neoplasms;Mediating;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;mRNA Expression;multicatalytic endopeptidase complex;Multiple Organ Failure;new therapeutic target;novel therapeutics;Organ;Pathogenesis;Patients;Peptide Hydrolases;Phosphorylation;Play;pre-clinical;protein degradation;protein kinase C-delta;Proteins;proteostasis loss;Public Health;Regulation;Research;Role;Sampling;Scheme;Sepsis;sepsis induced acute lung injury;sepsis induced ARDS;Severities;Signal Transduction;Stimulus;Subgroup;System;systemic inflammatory response;Tissues;Ubiquitin;ubiquitin isopeptidase

PROJECT_TITLE: Molecular regulation of immunoproteasome assembly in inflammatory diseases

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  How the genome is packaged within the nucleus and differentially utilized across different cells in the body is unknown. This project examines how changes in the structure of the genome during heart disease influences the progression of the symptoms. These investigations examine distinct cell types in the heart to identify new strategies to treat heart failure.

PI_NAMEs: VONDRISKA, THOMAS M. (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Actins;adrenergic stress;Adult;Architecture;ATAC-seq;Biology;Cardiac;cardiogenesis;Cardiovascular system;Cell Nucleus;Cell Separation;cell type;Cells;Chromatin;Chromatin Loop;Chromatin Modeling;chromatin remodeling;Chromatin Structure;Data;Development;Disease;Disease Progression;Engineering;Enterobacteria phage P1 Cre recombinase;Environment;Enzymes;EP300 gene;Epigenetic Process;experimental study;extracellular;Family;Female;Fibroblasts;Fluorescent in Situ Hybridization;gain of function;Gel;Gene Activation;Gene Expression;gene repression;Genes;Genetic Materials;Genetic Transcription;Genome;genomic locus;Genomics;Grant;Guide RNA;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Histology;Histone H1;histone modification;Histones;Hypertrophy;in vivo;Incidence;Injury;insight;Interphase Cell;Investigation;ischemic injury;Isoproterenol;Job Description;loss of function;male;Maps;Measures;Microscopy;Modification;Molecular;Molecular Conformation;Molecular Target;Mus;Muscle Cells;Myocardial Infarction;Myofibroblast;Neighborhoods;novel;Nuclear;Organ;Organism;Pathogenesis;Pathologic;periostin;Phenotype;Physical condensation;postmitotic;preservation;pressure;Process;Proliferating;promoter;protein expression;Protein Isoforms;reconstruction;Reproducibility;Resolution;response;response to injury;Role;sex;Sex Differences;Signal Transduction;simulation;single-cell RNA sequencing;Smooth Muscle;Structure;Symptoms;Taxes;Testing;three-dimensional modeling;Tissues;tool;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transgenic Mice;Validation;vector;Work

PROJECT_TITLE: Dynamics of cardiac nuclei in heart disease

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE In humans, mutations of SAGA subunits have been implicated in developmental disorders, neurological, endocrinological, and immunological diseases, and several cancers. Any novel and specific function assigned to the conserved yeast SAGA subunits will yield new mechanistic insight and will likely be generalizable to higher eukaryotes. By revealing a new and predictive mechanistic understanding for the precise effects of SAGA mutations, our work has the potential to radically transform how human diseases are studied and how drugs are developed.

PI_NAMEs: NEUERT, GREGOR  (contact)

PROJECT_TERMS: Biological Process;Cell Fraction;Cell model;Cells;Chromatin;Chromatin Structure;Complex;Computer Analysis;Computer Models;conditional mutant;Cytoplasm;Data;Data Analyses;developmental disease;Disease;Endocrinology;Eukaryota;experimental analysis;experimental study;Gene Expression;Gene Expression Regulation;gene induction;Gene Proteins;Genes;Genetic Transcription;Glycerol;Goals;histone acetyltransferase;Histones;Human;human disease;Immune System Diseases;innovation;insight;Kinetics;Knowledge;Lead;Malignant Neoplasms;Measurement;Measures;Medical;member;Messenger RNA;Modeling;Multiprotein Complexes;mutant;Mutate;Mutation;Neurologic;novel;Nuclear;Osmolar Concentration;Osmosis;p38 Mitogen Activated Protein Kinase;Pharmaceutical Preparations;Population;predictive modeling;Process;Proteins;Regulation;RNA;RNA Degradation;Role;SAGA;Signal Transduction;single cell analysis;single molecule;Spatial Distribution;spatiotemporal;Stress;TATA-Box Binding Protein;Testing;Time;Transcript;Transcription Initiation;ubiquitin isopeptidase;Work;Yeasts

PROJECT_TITLE: Single cell analysis of dynamic gene regulation

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative A wide assortment of chromatin-modifying proteins activate enhancers in a tightly regulated process involving histone methylation, histone acetylation, and chromatin reader proteins that bind and recruit transcriptional machinery to these locations. Mutations in several chromatin enhancer activation factors lead to human craniofacial disorders. Studying the craniofacial genome for how these chromatin-modifiers bind and regulate enhancer activity and transcription is essential towards elucidating craniofacial disorder pathogenicity, and therapeutic approaches that rescue these chromatin states may be applicable towards these disorders.

PI_NAMEs: SHPARGEL, KARL BRYAN (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acetylesterase;Anterior;Binding;Binding Proteins;Biochemical;Biology;Bromodomain;Cartilage;Cell Count;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;Cephalic;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Cleft Palate;Complex;craniofacial;craniofacial development;craniofacial disorder;Data;Defect;Development;Disease;Downstream Enhancer;Ear;Embryo;Enhancers;Enzymes;Epigenetic Process;Etiology;Event;Exhibits;experience;experimental study;Face;face bone structure;Gene Expression Regulation;Genetic;Genetic Diseases;Genetic Transcription;Genome;Genomic approach;Genomics;Histone Acetylation;Histone H3;histone methylation;histone methyltransferase;histone modification;Histones;Homologous Gene;Human;Impairment;improved;in vivo;Kabuki Make-Up Syndrome;Knock-in;Knock-out;Lead;Location;loss of function;Lysine;Mandible;Maps;Methylation;Methyltransferase;Modeling;Molecular;morphogens;Multipotent Stem Cells;Mus;mutant;Mutate;Mutation;Neural Crest;Neural Crest Cell;Neurophysiology - biologic function;novel;osteoblast differentiation;Osteoblasts;Osteogenesis;Pathogenesis;Pathogenicity;Pathway interactions;Phenocopy;Phenotype;Play;Point Mutation;Post-Translational Protein Processing;Process;programs;protein complex;Proteins;Proteomics;Publishing;Reader;recruit;Regulation;Regulatory Pathway;Reporter;Research;Role;Shapes;skull base;Sorting;stem cell biology;stem cells;Therapeutic;Tissues;transcription factor;Transcriptional Activation;Y Chromosome

PROJECT_TITLE: Enhancer activation mechanisms in cranial neural crest osteoblast differentiation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ORG_CITY: MADISON

ORG_NAME: WISCONSIN DEPT/AGRI/TRADE/CONSUM/ PROT

ORG_STATE: WI

PHR: Project Narrative Overall This cooperative agreement is intended to enhance the capacity and capabilities of state human and animal food testing laboratories in support of an integrated food safety system. Specifically, through sample testing in the areas of microbiology, chemistry, and radiochemistry, and the development of special projects that would support and expand that testing. This project will strengthen and improve the collaboration of surveillance testing activities between the FDA and our state and local laboratory partners to continue building a nationally integrated laboratory science system.

PI_NAMEs: KELLEY, GIL  (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Laboratory Flexible Funding Model - Chemistry and Microbiology Disaplines


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPT OF AGRIC/CONSUM SRVCS

ORG_STATE: FL

PHR: Project Narrative  Laboratory Flexible Funding Model (LFFM) (U19) Clinical Trials Not Allowed PAR-20-105 Florida Department of Agriculture and Consumer Services (FDACS) Division of Agricultural Environmental Services (AES) Proposal to FDA for Participation in the Laboratory Flexible Funding Model (LFFM) (U19) Clinical Trials Not Allowed PAR-20-105 The Florida Department of Agriculture and Consumer Services (FDACS) is requesting funding to enhance the capacity and capabilities of Florida's Animal Food testing laboratory in support of an integrated food safety system through participation in the Laboratory Flexible Funding Model (LFFM) (U19) Clinical Trials Not Allowed PAR-20- 105.

PI_NAMEs: HAYSLIP, GEORGE  (contact)

PROJECT_TITLE: FDACS - PAR-20-105 - Laboratory Flexible Funding Model


ORG_CITY: COLUMBIA

ORG_NAME: SOUTH CAROLINA DEPARTMENT OF PUBLIC HEALTH

ORG_STATE: SC

PHR: SC DHEC Overall Project Narrative The overall purpose of this cooperative agreement is to enhance the capacity and capabilities of state human and animal food testing laboratories in support of an integrated food safety system. South Carolina will enhance and support a national level integrated system by expanding routine surveillance of human and animal food products and enhancing preparedness for food defense response while also contributing to a growing understanding of microbial ecology and diversity through whole genome sequencing of foodborne pathogens. These projects will serve as a foundation to strengthen and improve the FDA’s efforts to prevent foodborne illness and minimize exposures in order to build upon a nationally integrated laboratory science system and equips partner laboratories with additional resources to increase sample throughput capacity within the state.

PI_NAMEs: DAVIS, MEGAN  (contact)

PROJECT_TITLE: South Carolina Department of Health and Environmental Control Laboratory Flexible Funding Model Grant Submission


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Severe Fever with Thrombocytopenia virus (SFTSV) is a highly pathogenic, tick- transmitted virus that causes a severe hemorrhagic disease. There are no treatments or prophylactics available for SFTSV. This proposal will develop and analyze immune responses to mRNA and recombinant viral vaccines for use either alone or in combination to prevent infection.

PI_NAMEs: BATES, PAUL  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affinity;Andes Virus;Animal Model;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigen-Presenting Cells;Antigens;Asia;B-Cell Activation;Case Fatality Rates;China;Clinical;Data;Death Rate;Development;Disease;Disease Outbreaks;Distant;Domestic Animals;Dose;Ebola Vaccines;Ebola virus;Emerging Technologies;epidemic potential;Fever;Formulation;Foundations;Future;gastrointestinal symptom;Genes;Genus Phlebovirus;Geographic Distribution;Glycoproteins;Goals;Hemorrhage;Human;human pathogen;IFNAR1 gene;Immune response;Immunity;Immunize;Immunocompetent;immunogenicity;Infection;Infection prevention;Influenza;Innate Immune Response;Interferons;Intervention;Japan;Knock-out;Knockout Mice;Knowledge;Korea;Lassa;Leukopenia;lipid nanoparticle;Membrane Glycoproteins;Messenger RNA;Modeling;Monoclonal Antibodies;mortality;mouse model;mRNA lipid nano particle vaccine;mRNA Stability;Mus;National Institute of Allergy and Infectious Disease;Natural Immunity;neutralizing antibody;Nucleosides;Orthobunyavirus;pathogen;pathogenic virus;Pathogenicity;Pathology;Powassan virus;prevent epidemics;programs;prophylactic;protective efficacy;recombinant viral vector;recombinant virus vaccine;Recombinants;Recommendation;Regimen;Reporting;Research;research and development;Research Priority;Respiratory syncytial virus;response;RNA;RNA vaccination;RNA vaccine;Russia;Severe Fever with Thrombocytopenia Syndrome Virus;Structure of germinal center of lymph node;Surface;Symptoms;synergism;System;T cell response;Technology;Therapeutic;therapeutically effective;Thrombocytopenia;tick transmission;tick-borne;Translations;Vaccinated;Vaccination;vaccine development;vaccine platform;vaccine strategy;vaccine trial;Vaccines;vector;vector tick;vector vaccine;Vesicular stomatitis Indiana virus;Vietnam;Viral;viral transmission;Viral Vaccines;Viral Vector;Viremia;Virus;Virus Diseases;Wild Animals;ZIKA

PROJECT_TITLE: Development of vaccines targeting a tick-borne phlebovirus


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE There continues to be a need for rigorous scientists, and especially physician-scientists, in the field of hematology, since this discipline is at the forefront of translational investigation and modern medicine. This grant will support the training of hematology researchers at a critical time in their careers - the transition from post- doctoral fellow to independent investigator - and develop scientists that will advance hematology and health care in the USA.

PI_NAMEs: ABKOWITZ, JANIS L (contact)

PROJECT_TERMS: Hematology;Training

PROJECT_TITLE: HEMATOLOGY TRAINING


PHR: Project Narrative Nonmuscle myosin motors play important roles in almost every physiological process, including cell migration, cell adhesion, and cell division. A variety of human diseases are the direct result of defects in nonmuscle myosin motors, yet the underlying molecular mechanisms are unknown. We will apply structural, biochemical and cell biological approaches to define how nonmuscle myosins work to contribute to our understanding of their fundamental roles in human health and disease.

PI_NAMEs: CHINTHALAPUDI, KRISHNA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Actins;Address;Adopted;Architecture;ATP phosphohydrolase;Binding;Biochemical;Biological;Biological Assay;Biology;Cell Adhesion;Cell division;cell fixing;cell motility;Cell Physiology;Cells;Cellular biology;Computer software;computerized data processing;Cryoelectron Microscopy;Cues;Cytoskeleton;Data;deafness;Defect;design;Development;Disease;Electron Microscopy;Engineering;Enzyme Activation;enzyme activity;Enzymes;Equilibrium;Eukaryotic Cell;Filament;flexibility;Fluorescence Microscopy;Foundations;Future;Generations;Goals;Health;Heart Diseases;Hematological Disease;Heterogeneity;high resolution imaging;Human;human disease;In Vitro;innovation;Kinetics;Knowledge;Length;Malignant Neoplasms;Measurement;mechanotransduction;Microfilaments;migration;Modeling;Molecular;Molecular Conformation;Motility;Motor;Motor Activity;mutant;Mutation;Myosin ATPase;Myosin S-2;Nephritis;Nervous System Disorder;non-muscle myosin;novel;Nucleotides;paralogous gene;Physiological Processes;Play;Process;programs;Property;protein complex;Protein Dephosphorylation;Protein Engineering;Proteins;Regulation;Research;Resolution;Role;sensor;Structure;Techniques;Testing;Textbooks;Therapeutic;Tissues;tool;Work;X-Ray Crystallography

PROJECT_TITLE: Structure and function of nonmuscle myosins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: This research application is relevant to the public health because it will characterize an important group of proteins called androgen receptor-interacting proteins, which bind androgen receptor to modulate androgen-mediated functions in reproductive organs including the testes and prostate gland, as well non-reproductive systems such as the pancreas, musculoskeletal system, and motor neurons. Moreover, androgen receptor-interacting proteins represent a special class of genetic and biochemical modifiers of pathological functions underlying androgen receptor-related diseases that afflict multiple organ-tissue systems in humans. The findings of this research proposal will be directly responsive to part of NIH’s mission to provide fundamental knowledge about the nature and behavior of living systems and the long-term goal to uncover new knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: WRIGHT, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Androgen Receptor;androgen sensitive;Androgens;Attenuated;Behavior;Binding;Binding Proteins;Biochemical;Biological Assay;Biomedical Research;Biotin;Castration;Cell model;Cells;cellular development;Cloning;Color;Communication;Communities;Complementary DNA;Coupled;Darkness;Data;Data Set;disability;Disease;druggable target;Family member;Foundations;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Glean;Goals;Gonadal Steroid Hormones;guided inquiry;Health;Hormone Responsive;Human;insight;Kinetics;Knowledge;Label;Length;Life;Ligand Binding Domain;Ligands;Ligation;Light;LNCaP;Maps;Mass Spectrum Analysis;Mediating;Mission;Modeling;Molecular;Molecular Probes;Molecular Structure;Motor Neurons;Musculoskeletal System;Nature;new therapeutic target;non-genomic;novel;Nuclear Hormone Receptors;Organ;Organism;Outcome;Pancreas;Pathologic;Pathology;Pathway interactions;Physiological;predictive modeling;Prostate;prostate cancer cell;Prostatic Neoplasms;protein complex;Protein Dynamics;protein protein interaction;Proteins;Proteomics;Public Health;Qualifying;receptor;Receptor Activation;receptor function;Receptor Signaling;Receptor-Interacting Protein;reproductive;reproductive organ;Research;Research Proposals;Resistance;Resolution;Resources;response;RIPK3 gene;RNA Splicing;Signal Transduction;spatiotemporal;spinal and bulbar muscular atrophy;steroid hormone receptor;System;Techniques;Testing;Testis;Time;Tissues;transmission process;United States National Institutes of Health;Variant;Vision

PROJECT_TITLE: Construction of the Androgen Receptor Interactome: A Molecular Framework for Probing Genetic Interactions in Androgen-Dependent Signaling

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Untreated opioid withdrawal and craving leads to poor treatment retention and high rates of relapse among those seeking treatment for opioid use disorder. Opioid withdrawal and craving are influenced by transmitter systems (dopamine, serotonin) that may not be fully treated with existing medications. We will evaluate whether buspirone (Buspar), an FDA-approved medication that acts on these systems, mitigates withdrawal and craving during residential and outpatient treatment.

PI_NAMEs: BERGERIA, CECILIA  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Ache;Acute;Address;Agonist;Ambulatory Care;antagonist;Anxiety;Biochemical;Blood;bone;Buprenorphine;Buspirone;Caring;Cells;Clinical;conformational alteration;craving;Data;depression model;desensitization;diaries;disorder risk;Dopamine;Dopamine D2 Receptor;Dose;Double-Blind Method;Dropout;Economic Burden;efficacy evaluation;Enrollment;Evaluation;FDA approved;improved;Individual;inpatient service;Inpatients;Label;male;Marketing;Measurement;Measures;Methods;Molecular Conformation;Morphine;Muscle;Naltrexone;Opioid;opioid epidemic;opioid tapering;opioid use;opioid use disorder;opioid withdrawal;Outpatients;Participant;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilot Projects;Placebo Control;Placebos;pre-clinical;pre-clinical research;preclinical study;primary outcome;Publishing;Randomized;receptor;Relapse;relapse prevention;relapse risk;Reporting;Research Design;Research Support;Residential Treatment;Risk Reduction;Rodent;Safety;Sampling;Serotonergic System;Serotonin;Serotonin Receptor 5-HT1A;Severities;Standardization;Stress;System;Treatment outcome;treatment planning;Urinalysis;Visit;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Evaluating a Mechanistically-Supported Pharmacotherapy to Treat Acute and Protracted Opioid Withdrawal

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

ORG_STATE: MA

PHR: Project Narrative The Massachusetts Department of Public Health State Public Health Laboratory (MASPHL) is applying for funding under PAR-20-105, the Laboratory Flexible Funding Model (U19). By participating in projects related to routine surveillance of human and animal food products, Massachusetts will be contributing to a National Integrated Food Safety System. Routine sampling testing allows Massachusetts officials to assess the overall burden of pathogens and chemical contaminants in the food supply, and to respond quickly before there is human illness. MASPHL will also use the funding opportunity to enhance programs such as food defense which will allow Massachusetts to be able to respond to intentional or unintentional threats to the food supply. Lastly, Massachusetts residents will benefit from the funding opportunity as MASPHL is able to develop new capacity for the detection of Cyclospora in food products following outbreaks in 2019, and to assess the level of allergens in the food supply.

PI_NAMEs: FORTES, ESTHER  (contact)

PROJECT_TITLE: Lab Food Safety Testing Program


ORG_CITY: Trenton

ORG_NAME: NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS

PHR: New Jersey Food Testing Program - Food Safety and Defense (2020-2025): Overall Narrative The New Jersey Department of Health will test foods for microbiological, chemical, and radiological contaminants, further integrate its food testing into a unified food defense system, and expand its testing capabilities and capacity to support FDA activities. The data will be used to remove potentially harmful products from the market and proposed activities will further safeguard public health and support FDA priorities by providing federal and State partners with critical microbial, chemical, and radiological contaminant data and capacity they can use to enhance their own food defense practices.

PI_NAMEs: FAN, ZHIHUA  (contact);KIRN, THOMAS JOSEPH


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

PHR: Project Narrative Food and feed safety laboratories serve to create public goods through the creation of knowledge using analytical science that informs the creation of sound policy, provides consumer confidence against adverse economic impacts in a global marketplace, and protects the health of the general public from food and feed adulteration or pathogenic outbreaks. The accreditation of food and feed safety laboratories, through ISO/IEC 17025, is considered a gold standard in demonstrating the competence to perform defensible laboratory science in support of these public goods. The Laboratory Accreditation Rule of the 2011 Food Safety Modernization Act, implemented by the Food and Drug Administration, makes the activity of achieving and maintaining accreditation pivotal for food and feed safety laboratories to actively participate in a fully integrated food safety system.

PI_NAMEs: NAGEOTTE, MICHAEL ;WILLIAMS, ELIJAH TIMOTHY (contact)

PROJECT_TITLE: Expansion of Pennsylvania's State Food and Feed Laboratory Services in Response to the 2011 Food Safety Modernization Act, Laboratory Accreditation Rule, and the FDA Integrated Food Safety System


ORG_CITY: RICHMOND

ORG_NAME: VA  DIVISION/CONSOLIDATED LAB SRVS

PHR: PAR-20-105 Laboratory Flexible Funding Model (LFFM) (U19) Overall Component  Division of Consolidated Laboratory Services  Principal Investigators: Christopher Waggener, Ph.D. SF424: Other Project Information Project Summary: The Division of Consolidated Laboratory Services (DCLS) is the public health laboratory for the Commonwealth of Virginia and offers a wide variety of laboratory testing services for state and federal agencies, local governments and other states in support of public health, environmental protection and emergency response. DCLS provides surveillance and emergency response testing of food samples for the Virginia Department of Agriculture and Consumer Services (VDACS) Food Safety Program by offering nearly comprehensive testing of food samples by microbiology, chemistry and radiochemical methods. DCLS obtained ISO/IEC 17025 accreditation in January 2017 and has expanded this scope of accreditation to include nine test methods, and proposes to maintain and further expand this accreditation scope to include up to three new test methods during the budget period. DCLS’ experience with testing MFRPS food samples for our state partners along with participation in proficiency testing events, dedicated BSL-2 trained staff, dedicated laboratory space and equipment along with our long-standing history with the FERN Network, sets DCLS apart from other state testing facilities. If granted these funds for human and animal food safety/defense testing for all three disciplines, DCLS is committed to providing emergency testing, surveillance and regulatory human and animal food testing for any situation when called upon by the FDA. DCLS is also committed to providing testing support for national security events as well as participate in all proficiency tests and training when applicable. DCLS will participate in FDA-requested exercises, and/or surveillance activities to support and maintain a state of readiness. In an effort to maintain a state of readiness, DCLS will ensure analysts are trained and have passed competency exercises, all equipment will remain in working order, and reagents and supplies are available or could easily or quickly be procured.

PI_NAMEs: PRICE, JESSICA MAITLAND (contact);WOODS, AMANDA

PROJECT_TITLE: Division Of Consolidated Laboratory Services Laboratory Flexible Funding Model


NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: The goal of the proposed research is to investigate the mechanism by which reactive oxygen species derived from NADPH oxidase control axonal growth and guidance. This study has the potential of breaking new grounds in axonal growth and guidance signaling. Therefore, it will not only advance our basic understanding of nervous system development but also impact the design of treatments to enhance axonal regeneration in neurodegenerative diseases and central nervous system injuries.

PI_NAMEs: SUTER, DANIEL MARCEL (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Address;Adhesions;Adult;Affect;Antioxidants;Aplysia;Axon;axon growth;axon guidance;axon regeneration;axonal pathfinding;Behavior;Behavioral Assay;Biological Assay;Biological Models;Biosensor;Cell Physiology;Cell Proliferation;Cells;central nervous system injury;Cues;Cytoskeleton;Data;Development;Dyes;Embryo;Environment;Evolution;experience;extracellular;Eye Development;Fishes;Fluorescent Dyes;Functional disorder;Goals;Growth;Growth Cones;Hydrogen Peroxide;Image;Imaging Techniques;Immunity;improved;In Vitro;in vivo;inhibitor;innovation;insight;Knowledge;live cell imaging;Measures;Mediating;migration;Molecular;Motility;Movement;mutant;NADP;Nerve Regeneration;nerve supply;Nervous System;nervous system development;Nervous System Trauma;neurite growth;Neurodegenerative Disorders;neuron development;neuron regeneration;neuronal growth;Neurons;novel;Oxidases;Physiological;Physiology;Play;Positioning Attribute;Process;Proteins;Publishing;Rattus;Reactive Oxygen Species;regeneration following injury;Research;response;Retinal Ganglion Cells;retinotectal;Role;Second Messenger Systems;Signal Transduction;Signaling Molecule;small molecule;Source;src-Family Kinases;Structure;Testing;therapy design;Transgenic Organisms;Visual;Work;Zebrafish

PROJECT_TITLE: NADPH oxidase regulates growth cone guidance

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Lung;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Proposal Narrative Bone marrow transplantation is a preferred treatment for high-risk acute leukemia and other bone marrow diseases. Inflammation of the GI tract and lung, caused by donor white cells, is a significant cause of complications after transplant. We have found that a population of immune cells that block inflammation is lost after bone marrow transplantation. The goals of the current work are to better understand why these cells don’t develop after transplant. This should allow us to develop new methods to generate/maintain these cells to prevent transplant-associated inflammation.

PI_NAMEs: SERODY, JONATHAN S. (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute leukemia;Address;Adult;Allogenic;Autologous Stem Cell Transplantation;B-Lymphocytes;Behavior Therapy;Biology;Blood;Blood Circulation;Bone Diseases;Bone Marrow;Bone Marrow Cells;Bone Marrow Diseases;bone marrow failure syndrome;Bone Marrow Stem Cell;Bone Marrow Transplantation;Bronchiolitis Obliterans;Categories;Cells;Collaborations;Complication;congenital bone marrow failure;Cues;cytokine;Development;drug discovery;Dysmyelopoietic Syndromes;Epigenetic Process;Fetal Liver;fetus cell;Gastrointestinal tract structure;GATA3 gene;Generations;Genetic;Genetic Transcription;Germ Lines;Goals;graft vs host disease;graft vs leukemia effect;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hepatocyte;high risk;Human;IL17 gene;Immune;immune reconstitution;Immune response;Immune system;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferon Type II;Interleukin-1 beta;Interleukin-12;interleukin-22;interleukin-23;Knowledge;Laboratories;Langerhans cell;Lead;Leukocytes;Lung;Lung infections;Lymphocyte;Lymphoid Cell;Lysine;Maintenance;Malignant - descriptor;Mediating;Methods;Molecular;Morbidity - disease rate;mortality;mucosal site;Mus;Myeloproliferative disease;Natural regeneration;novel strategies;novel therapeutics;pathogen;Pathogenesis;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Play;Population;post-transplant;precursor cell;prevent;Process;receptor;reconstitution;Relapse;Resources;response;Risk Factors;Role;Stem cell transplant;Syndrome;T-Lymphocyte;Time;tissue repair;transcription factor;Transplantation;tumor;Viral Bronchiolitis;Virus Diseases;Work

PROJECT_TITLE: Enhancing Innate Immune Reconstitution Post Allogeneic HSCT.

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: PROJECT NARRATIVE Predoctoral training in cancer biology is directly relevant to public health. Understanding, preventing, and treating cancer remains a national priority. The mission of the CBTP addresses a critical need to train the next generation of cancer researchers in a large region of the United States, in order to provide a foundation for tomorrow’s clinical advances in the treatment and management of this disease.

PI_NAMEs: BLACK, JENNIFER D. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Cancer Biology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Underage Drinking

PHR: PROJECT NARRATIVE The present application proposes to conduct secondary analyses of accelerated longitudinal cohort sequential data from the Washington State Young Adult Health Study. The project will examine changes in young adult substance use, related risk behaviors, and substance use related risk factors from before to during the COVID- 19 pandemic among young adults in a state where alcohol, tobacco, and cannabis sales and use are legal for adults age 21 and over. Findings from the proposed project will inform tailoring and development of prevention and intervention efforts aimed at reducing problem behaviors and improving public health in a situation that poses serious challenges for effective long-term planning of such efforts.

PI_NAMEs: GUTTMANNOVA, KATARINA  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 19 year old;21 year old;Acceleration;Address;Adult;Affect;Age;Age Years;Alcohol consumption;Alcohols;authority;Automobile Driving;Behavior;behavioral health;Cannabis;Characteristics;cohort;Communities;community-level factor;COVID-19;COVID-19 pandemic;Data;data cleaning;Development;differences in access;disorder risk;Disparity;Driving While Intoxicated;Economics;Education;Ethnic Origin;experience;Financial Hardship;Frequencies;Funding;gender minority status;Health;Health Surveys;Healthcare;high risk;improved;Individual;Intervention;Intoxication;Legal;Link;Longitudinal cohort;marijuana use;neighborhood disadvantage;Occupations;Outcome;pandemic disease;pandemic impact;pandemic stressor;Pattern;permissiveness;Persons;Population;Prevalence;Prevention;Problem behavior;Process;Public Health;Race;Recovery;Resources;response;Risk;Risk Behaviors;Risk Factors;Role;Sales;Sampling;SARS-CoV-2 infection;secondary analysis;Services;sex;Sexual and Gender Minorities;sociodemographics;Source;Stress;stressor;Subgroup;substance use;Time;Tobacco;tobacco products;Tobacco use;tobacco user;university student;vaping nicotine;Washington;Work;young adult

PROJECT_TITLE: Covid-19 pandemic and changes in the prevalence, patterns, and trajectories of substance use and related health risk outcomes among young adults in WA State


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The University of Pittsburgh pre-doctoral training program in Cellular Approaches to Tissue Engineering and Regeneration educates and trains the next generation of scientists in regenerative medicine. Our multidisciplinary training creates researchers who can provide new therapies for all eligible diseases through regenerative medicine.

PI_NAMEs: DUNCAN, ANDREW W;MONGA, SATDARSHAN SINGH (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Tissue Engineering;tissue regeneration


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lymphatic Research;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Findings from the past few years have changed traditional views about the role of lymphatics in health and disease. Lymphatics are now considered to be active, tissue-specific players in major physiological and pathophysiological processes, including cardiovascular, neurological, and metabolic diseases. Improving our understanding of the metabolic landscape of LECs in normal and pathological vascular beds should help us better characterize the complex, step-by-step process leading to the formation of fully mature vascular networks, and offer novel approaches for treating vascular diseases. Accordingly, the stimulation or blockage of LEC metabolism could potentially be used to promote or inhibit vessel growth.

PI_NAMEs: OLIVER, GUILLERMO C (contact);SOSA-PINEDA, BEATRIZ

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: acute pancreatitis;Adult;alternative oxidase;angiogenesis;Angiogenesis Inhibitors;Birth;Blood;Blood Vessels;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardioprotection;Cardiovascular Diseases;Cell Cycle;Cell Differentiation process;cell fate specification;Cell Line;Cell Physiology;Cell Proliferation;Cells;Cellular Metabolic Process;Chemicals;chronic pancreatitis;Complex;Data;Development;Disease;DNA Damage;Electron Transport;Electron Transport Complex III;Embryo;Embryonic Development;Endothelial Cells;Exhibits;Fibrosis;genomic locus;Glycolysis;Growth;Health;Heart;heart function;Heart Injuries;Heterogeneity;Hybrids;immune clearance;improved;In Vitro;in vivo;Infarction;Inflammation;Injections;Injury;insight;Ischemia;kidney medulla;Knowledge;Lymph;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;lymphatic vasculature;lymphatic vessel;Lymphocyte;Maintenance;Malonates;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial metabolism;Molecular;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Myocardial Infarction;Natural regeneration;Neonatal;neonatal mice;Nervous System Disorder;novel strategies;Organ;organ repair;Organelles;overexpression;Oxidative Phosphorylation;Oxidoreductase;paracrine;Pathologic;Physiological;postnatal;prevent;Process;Production;Proliferating;Reactive Oxygen Species;Regenerative capacity;Regenerative response;Regulation;Respiration;revascularization;Role;Route;sensor;Signal Transduction;Specific qualifier value;Structure of sinus venosus of sclera;Succinate Dehydrogenase;Succinates;Therapeutic;Therapeutic Uses;tissue injury;Tissues;vascular bed;Vascular Diseases;Work

PROJECT_TITLE: Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesis

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Electronic Nicotine Delivery Systems;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative Despite increasing popularity, human health hazards associated with exposure to e-cigarette (e-cig) aerosols are poorly defined. New data suggests significant health risks may be associated with inhalation of hazardous metals, including known neurotoxicants, released from various components of the e-cig device, and also varying depending on e-liquid flavoring and operation parameters. Human cell culture and animal models will be used to identify which e-cig aerosol mixtures pose significant neurotoxic risk(s), with particular emphasis on individuals genetically-susceptible for neurodegenerative disease.

PI_NAMEs: HILPERT, MARKUS ;RE, DIANE BERENGERE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adverse effects;Aerosols;Affect;Air;Aldehydes;Analytical Chemistry;Animal Model;Animals;Area;authority;base;Blood;Brain;brain health;brain tissue;Calcium;cancer risk;carcinogenicity;Carcinogens;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cell model;Cessation of life;Characteristics;Chromium;Chronic;Cigarette;Clinical;Cognition;Cognitive deficits;Copper;Corpus striatum structure;Cotinine;Data;density;Devices;Disease;disease model;disorder risk;dopaminergic neuron;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Environmental Engineering technology;Epidemiology;Etiology;Exhibits;exposed human population;Exposure to;Flavoring;General Population;Genetic Determinism;Genetic Predisposition to Disease;Glycerol;Health;Health Hazards;Heating;Human;human subject;Image;Impaired cognition;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inductively Coupled Plasma Mass Spectrometry;Inhalation;Iron;Knock-in;Knowledge;Laboratories;Lead levels;Length;Link;Liquid substance;LRRK2 gene;Manganese;Measures;Mediating;Metal exposure;Metals;Motor;motor deficit;motor impairment;mouse model;Mus;Mutation;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;Neurotoxins;Nickel;Nicotine;novel;operation;Parkinson Disease;particle;Pathologic;Patients;Perception;Phase;Policy Maker;Predisposition;premature;prevent;Propylene Glycols;Public Health;Recording of previous events;Reporting;Research Personnel;respiratory;Respiratory Disease;Risk;Role;Sampling;secondhand aerosol;Selenium;Smoker;Smoking;Solvents;sporadic Parkinson's Disease;Synapses;System;Testing;Tobacco;tobacco smokers;Toxic effect;Vanadium;vaping;vapor;Youth;Zinc

PROJECT_TITLE: Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(50)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;Health Services

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Although routine use of patient-reported outcomes capturing the lived experience of chronic inflammatory skin disease in clinical practice has the potential to improve quality of care, patient-reported outcomes are rarely used in the clinical setting. This research will prioritize the outcome domains most meaningful to patients with chronic inflammatory skin disease and develop and field test a novel patient-reported outcome profile that uses item response theory-based Patient-Reported Outcomes Measurement Information System (PROMIS) scales to enable efficient administration in a busy clinical setting. The results of this work will facilitate the routine use of patient-reported outcomes in the clinical setting, which has the potential to improve patient satisfaction, symptom management, treatment selection, and patient outcomes.

PI_NAMEs: BARBIERI, JOHN  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acne;Address;Advisory Committees;Affect;Area;Atopic Dermatitis;Award;Calibration;career;career development;Caring;chronic inflammatory skin;Client satisfaction;Clinic;Clinical;clinical care;clinical practice;Clinical Research;comparative effectiveness;Computers;concept mapping;Cost effectiveness research;Data;Dermatology;Development;Development Plans;Disease;economic cost;Electronic Health Record;emotional functioning;Environment;experience;Faculty;field study;Focus Groups;Foundations;Goals;Health Services Research;Health system;Healthcare;Hospitals;improved;indexing;Individual;Information Systems;innovation;insight;instrument;Knowledge;knowledge base;Learning;Lived experience;Measurement;Measures;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modernization;Nature;novel;Outcome;Outcome Measure;Outcomes and Health Services Research;Patient Care;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Physical Function;Physicians;Positioning Attribute;Property;Psoriasis;Psychometrics;psychosocial;Qualitative Research;Quality of Care;Quality of life;Reporting;Research;research and development;Resources;response;Review Literature;Scientist;Selection for Treatments;Severity of illness;skills;Skin;skin disorder;sound;Surveys;symptom management;Symptoms;Techniques;teledermatology;tenure track;Testing;theories;Time;Training;treatment response;United States;Validation;Visit;Woman;Work

PROJECT_TITLE: Applying Item Response Theory to Improve Patient Reported Outcome Use in Dermatology Clinical Practice

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: NUTRITION

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative (Overall) This project describes the integration of efforts within Pennsylvania to ensure yearly completion of the goals established by the United States Food and Drug Administration of populating databases with ever more genome sequences of foodborne pathogens. This will promote public health by advancing the use of whole genome sequencing as a tool for outbreak investigations.

PI_NAMEs: DUDLEY, EDWARD G. (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Genome sequencing of foodborne pathogens by the Pennsylvania GenomeTrakr group


ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT OF AGRI AND CONSUMER SERV

PHR: Research & Related Other Project Information Project Narrative Component: Overall Through targeted surveillance of emerging or poorly characterized threats to food and feed safety, the Food & Drug Protection Division (FDPD) of the North Carolina Department of Agriculture & Consumer Services will provide state and federal regulatory partners with data to quantify threats and remove contaminated products from commerce. FDPD will also build analytical capabilities and capacity to support local, state, and federal emergency response activities.

PI_NAMEs: CONVERSE, REAGAN  (contact)

PROJECT_TITLE: Enhancing Human and Animal Food Testing in North Carolina in Support of an Integrated Food Safety System


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Health disparities research is a high priority for public health, but there is a vital element of healthcare quality with a paucity of data on disparities: compassion from treating clinicians. In an academic primary care network, we will use a mixed methods research design to test for differences in patient experience of clinician compassion between health disparity and non-disparity populations, and test if these differences are associated with greater patient distrust of the healthcare system among health disparity populations. We will also identify salient clinician behaviors that communicate compassion (or lack of) for health disparity populations, to inform a future R01 application that will develop and test patient-informed training curricula to raise clinician compassion for health disparity populations.

PI_NAMEs: TRZECIAK, STEPHEN WALTER (contact)

PROGRAM_OFFICER_NAME: WALKER, CHIVONNE L

PROJECT_TITLE: Compassion Disparities in Primary Care: A Mixed Methods Pilot Study

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE High levels of postpartum uninsurance among individuals with Medicaid-paid births contribute to rising rates of maternal morbidity and mortality in the United States. Passed in response to the COVID-19 Public Health Emergency, the Families First Coronavirus Response Act (FFCRA) and the American Rescue Plan Act (ARPA) allow for federal (FFCRA) and state (ARPA) extensions of pregnancy-related Medicaid eligibility through the first year postpartum. Our study will produce data of high scientific value to inform whether these large-scale interventions are an effective tool for improving maternal and child health and racial health equity in the year after birth.

PI_NAMEs: ADMON, LINDSAY KENNEDY (contact);DAW, JAMIE ROBERTA

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Improving Maternal and Child Health in the Year After Birth: An Early Evaluation of Postpartum Medicaid Eligibility Extensions

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND STATE DEPT OF HEALTH

ORG_STATE: RI

PHR: Project Narrative for State of Rhode Island PAR-20-105 Laboratory Flexible Funding Model (LFFM) (U19) Application: Overall Project Narrative The Rhode Island State Health Laboratories (RISHL) is applying for five years of LFFM funding to maintain and expand the food microbiology and chemistry testing capabilities of its state’s food testing laboratories. RISHL will continue to interactively support the integrated food safety system with the goal of providing an increased variety of testing services to respond to threats to the integrated food safety system and national food supply. The RISHL will administer, manage and coordinate the Analytical Projects under three disciplines of the Laboratory Flexible Funding Model (LFFM), Microbiology, Chemistry and Special Projects by leveraging its food laboratories’ organizational and quality management systems. RISHL’s Chief Environmental Laboratory Scientist and Chief Biological Laboratory Scientist will serve as principal and co-principal investigators. Together along with RISHL’s microbiology and chemistry Quality Assurance Officers, database administrator (to be hired) and its strong team of food laboratory scientists, RISHL will exercise its systems to fulfill the requirements of these multi-faceted disciplines. RISHL will work closely with the FDA NFSDX and ORAPP teams to further develop its data exchange capabilities and improve the submission and availability of its food sample collection and testing data to the FDA and network of state food safety surveillance and defense programs. 1

PI_NAMEs: HUARD, RICHARD C;KOTHAVADE, RAJENDRA  (contact)

PROJECT_TITLE: Enhancing State Food Microbiology and Chemistry Testing Laboratories Capacity and Capabilities In Support of the Integrated Food Safety System


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE Health Relevance Narrative: Instability of neuronal function can be debilitating, as evident from its association with numerous neurological disorders – including forms of epilepsy and migraine that present with acute attacks, or forms of neurodegeneration which can manifest in decades-long problems. In order to develop more effective treatments for disorders caused by unstable function, we need a better understanding of how neurons maintain stability. This proposal addresses that problem, using a genetic model system.

PI_NAMEs: FRANK, CARL ANDREW (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;Address;Ataxia;Binding;Biochemistry;Biological Models;Bone Morphogenetic Proteins;Buffers;Calcium;Chaperone Gene;Chemosensitization;Chronic;Data;Depressed mood;Development;Disease;Drosophila genus;Drosophila melanogaster;effective therapy;Electrophysiology (science);Engineering;Epilepsy;Event;Exhibits;Fibroblast Growth Factor Receptors;follow-up;Gene Mutation;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Screening;Glutamate Receptor;Goals;Health;Homeostasis;Hour;Image;Impairment;improved;inhibitor;Knowledge;Life;Link;loss of function;Maintenance;Mediating;Methods;Migraine;Modality;Modeling;Molecular;Molecular Chaperones;Monitor;Motor Neurons;Muscle;Nerve;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;Neuromuscular Junction;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;Neurotransmitter Receptor;Outcome;Output;Pathway interactions;Peptide Signal Sequences;pharmacologic;Pharmacology;Phase;Physiological;presynaptic;Process;Property;Puncture procedure;receptor function;Research;Research Design;Science;Semaphorins;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Sirolimus;Spermine;Stress;Synapses;synaptic function;Synaptic plasticity;System;Testing;Time;tool;transmission process;Work

PROJECT_TITLE: How discrete homeostatic signals stabilize synapse function across time

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Schizophrenia;Serious Mental Illness

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE  People with schizophrenia are characterized by marked impairments in cognitive function, for which there are no current pharmacological treatments. The development of an effective intervention for cognitive impairments remains a major therapeutic challenge. Prebiotics are dietary fibers that promote the growth or activity of gut microorganisms, which leads to the enhanced well-being of the host. The proposed R61 and R33 projects are designed to evaluate the hypothesis that prebiotic administration will lead to increased production of butyrate, through increased activity of butyrate-producing bacteria in the gut microbiota; the increase in serum butyrate levels will be associated with changes in cognitive function, symptoms, and metabolic measures.

PI_NAMEs: BUCHANAN, ROBERT W (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acetates;Affect;Affective Symptoms;Aftercare;Attention;Bacteria;Behavior;Biological;Brain;Butyrates;Cholesterol;Chromatin Structure;Chromosome 6;Clinical;cognitive benefits;cognitive function;cognitive performance;cytokine;Data;design;Development;Dietary Fiber;Disease;Double-Blind Method;effective intervention;effective therapy;efficacy trial;Enzymes;executive function;Family;Fasting;functional outcomes;Gene Expression;Genetic Polymorphism;Glucose;Growth;gut bacteria;gut microbiome;gut microbiota;Histone Deacetylase Inhibitor;Immune system;immune system function;immunoregulation;Impaired cognition;Impairment;improved;Incidence;Inflammatory;interest;Intervention;intestinal barrier;Intestinal permeability;Inulin;Light;Lipids;MATRICS Consensus Cognitive Battery;Measures;Mediating;Memory;Metabolic;microbiota composition;Microglia;microorganism;Multiple Abnormalities;Neurocognitive Deficit;Nonpharmacologic Therapy;novel strategies;Nuclear;Outcome;Participant;Pathway interactions;Performance;Personal Satisfaction;Persons;pharmacologic;Pharmacological Treatment;Placebos;prebiotics;processing speed;Production;Propionates;psychiatric symptom;Randomized;randomized placebo-controlled clinical trial;receptor;recruit;Schizophrenia;Secondary to;Serum;Short-Term Memory;side effect;social cognition;Symptoms;Therapeutic;Triglycerides;Verbal Learning;visual learning;Volatile Fatty Acids

PROJECT_TITLE: Prebiotic Treatment in People with Schizophrenia

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative  Heart failure remains a leading cause of mortality and morbidity for both men and women in the United States. Despite recent advances in the treatment of heart failure, new cases are still increasing by 10% per year which imposes a significant economic burden especially with the increased aging population. The current treatments for heart failure focus primarily on symptom management in the end-stage after irreversible remodeling has occurred by delaying the progression of the syndrome. Herein we aim to identify early changes following cardiac injury that drive this process to aid the diagnosis and development of therapies to prevent the irreversible remodeling and heart failure altogether.

PI_NAMEs: GE, YING  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acceleration;aging population;Animals;ATP phosphohydrolase;Biochemical Pathway;biomarker panel;Cardiac;Cause of Death;Clinical;clinical application;clinical diagnosis;clinically relevant;cohort;comorbidity;Diagnosis;Diagnostic;Early identification;Economic Burden;Elements;Enzymes;Equilibrium;experimental study;Family suidae;Functional disorder;Generations;Heart;Heart failure;heart function;Heart Injuries;heart metabolism;Human;Impairment;in vivo;Infarction;Ischemia;ischemic cardiomyopathy;Isometric Exercise;Lead;Link;Maps;Mass Spectrum Analysis;men;Metabolic;Metabolic Marker;Metabolic Pathway;metabolome;metabolomics;Methods;Microfilaments;Modeling;Modification;Molecular;Monitor;Morbidity - disease rate;mortality;multiple omics;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;novel;Outcome;Patients;Phase;Phosphorylation;Play;Post-Translational Protein Processing;Preparation;prevent;Process;Property;Proteins;Proteome;Proteomics;Reproducibility;Role;Sarcomeres;sex;Sex Differences;Signal Transduction;Skin;symptom management;Syndrome;Systems Biology;Testing;Therapeutic Intervention;therapy development;Tissue Sample;Tissues;translational potential;Translations;ultra high resolution;United States;Ventricular Remodeling;Woman

PROJECT_TITLE: Deciphering Myofilament Modifications in Ischemic Cardiomyopathy


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This project addresses the critical limitation in currently-available outcome measures of clinical disability progression in people with multiple sclerosis (MS), a limitation that has greatly impeded therapeutic development for people with the progressive form of the disease. Wearable tri-axial actigraphs are non- invasive, inexpensive devices that measure patterns of activity in a home-based, real-world setting; using our sophisticated analytic approach incorporating multiple dimensions of activity patterns, we are able to distinguish even small numbers of people with MS based on the gold-standard clinical disability score. We hypothesize that actigraphy-derived measures, alone or in combination with other currently-employed phase 2 trial outcome measures, will improve the prediction of clinical disability progression, setting the stage for meaningful breakthroughs in treatments by transforming the conduct of clinical trials among people with the devastating, progressive form of MS.

PI_NAMEs: MOWRY, ELLEN M. (contact)

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: Acceleration;actigraphy;Address;brain magnetic resonance imaging;Categories;Central Nervous System;cerebral atrophy;Clinical;clinical outcome measures;clinical predictors;Clinical Trials;cohort;Conduct Clinical Trials;Data;Development;Devices;Diagnosis;Dimensions;disability;Disability scale;disabling symptom;Disease;effective therapy;Enrollment;Exclusion;follow-up;Goals;Home;Image;Immune;Immunotherapy;improved;Injury;Label;Length;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Methods;middle age;Multiple Sclerosis;multiple sclerosis patient;Myelin;Nerve Degeneration;Neurologic;Neurons;Outcome;Outcome Measure;Patient Selection;Patients;Pattern;Persons;Phase;phase II trial;phase III trial;Phenotype;primary outcome;Publishing;Relapsing-Remitting Multiple Sclerosis;Risk;Sample Size;Secondary Progressive Multiple Sclerosis;Standardization;Subgroup;Technology;Therapeutic;therapeutic development;Therapeutic Trials;Time;wearable device;Wrist

PROJECT_TITLE: Home-based actigraphy to predict disability progression and enhance clinical trials in multiple sclerosis

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE X-linked hypophosphatemia (XLH) is the most common form of hereditary rickets, yet current treatments lack efficacy and no treatments are available to specifically improve associated dentoalveolar defects that substantially affect oral health and quality of life. Limited efficacy of treatments to date is in part related to complex etiology of mineralization defects in XLH, including local perturbations unaddressed by current treatment approaches. This project is designed to provide new insights into local mineralization defects in dentoalveolar tissues using a mouse model of XLH, and to test novel treatment approaches to prevent and ameliorate those defects.

PI_NAMEs: FOSTER, BRIAN LEE (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;Alkaline Phosphatase;alveolar bone;Anions;Ankylosis;Antibody Therapy;Automobile Driving;Biochemical;Biochemistry;Birth;bone;bone healing;Clinical Trials;Complex;conventional therapy;Defect;Deformity;Dental;dental abscess;Dental Enamel;Dental Pulp Exposure;Dentin;Dentin Formation;Dentition;design;Dihydroxycholecalciferols;Diphosphates;Disease;effective therapy;Epiphysial cartilage;Etiology;Extracellular Matrix;Extracellular Matrix Proteins;Familial hypophosphatemic bone disease;fibroblast growth factor 23;Fracture;Future;Genes;Genetic;Goals;healing;Histology;Human;Hydrolysis;Hypercalcemia;Hypophosphatemia;improved;In Vitro;in vivo;Incidence;Individual;Inherited;inhibitor;inorganic phosphate;insight;Kidney;Knowledge;long bone;Mechanics;Metabolism;microCT;mineralization;Modeling;mouse model;Mus;mutant;Mutation;Nephrocalcinosis;neutralizing antibody;novel;Oral;Oral health;Osteocytes;Osteogenesis;Osteomalacia;osteopontin;Outcome;overexpression;Pathogenicity;Pathologic;Patients;Periodontal Diseases;pharmacologic;Physiologic calcification;Pilot Projects;plasma cell membrane glycoprotein PC-1;pre-clinical;prevent;Production;Property;Protein Dephosphorylation;Proteins;Quality of life;Rickets;Role;Secondary Hyperparathyroidism;Serum;skeletal;Skeleton;standard of care;Testing;therapy design;Thinness;Tissues;Tooth Loss;Tooth structure;translational study;treatment effect;Treatment Efficacy;wasting

PROJECT_TITLE: Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked Hypophosphatemia

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: HONOLULU

ORG_NAME: HAWAII STATE DEPARTMENT OF HEALTH

ORG_STATE: HI

PHR: Hawaii State Department of Health  State Laboratories Division Laboratory Preparedness and Response Branch  Biological Response Section  Laboratory Flexible Funding Model (LFFM)  FOA: PAR-20-105  September 2020 - August 2021 Project Title: Hawaii' FERN Microbiology Laboratory's Role in Keeping Human Food Products Safe The overarching objective of the proposed projects is to maintain, enhance and strengthen the capacity and capabilities of Hawaii's FERN Microbiology laboratory in support of the nation's objective of building an integrated laboratory science system. By enhancing and strengthening Hawaii's FERN Microbiology laboratory, it will be able to test more food products using uniform validated national protocols and contribute to the accumulation of food testing data to identify microbial contamination of food products before reaching the consumers.

PI_NAMEs: GOSE, REMEDIOS B (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Hawaii's FERN Microbiology Laboratory's Role in Keeping Human Food Products Safe


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This research training program is focused on the scientific and professional development of advanced predoctoral thesis students in the area of neuronal degeneration caused by Human Immunodeficiency Virus (HIV). Through didactic coursework, laboratory research, career development training, this program will create a core of scientists who will contribute to the understanding, treatment and prevention of HIV-associated neuronal disorders.

PI_NAMEs: CATALFAMO, MARTA L.;MOCCHETTI, ITALO  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: neuroAIDS;Training Programs

PROJECT_TITLE: Training Program in NeuroHIV (TPNH)