NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Incarcerated people are a key population facing disproportionately high HIV burden in Zambia and across sub- Saharan Africa, yet almost nothing is known about their patterns of HIV risk behaviors or pre-exposure prophylaxis (PrEP) use during and after incarceration, which are thought to be times of substantial HIV risk. In the PreVAIL study, we will assess patterns of PrEP uptake and persistence, HIV incidence, and HIV risk perception among incarcerated people in Zambia, and conduct qualitative assessments of facilitators and barriers to efficacious PrEP use in this population both during and after incarceration. Insights from this study will generate currently unavailable data to inform the development of a differentiated service delivery model to deliver effective HIV prevention services to justice-involved persons, and provide critical information to surmount last-mile barriers to HIV epidemic control in Zambia, with applicability across other low- and middle-income countries.

PI_NAMEs: CLAASSEN, CASSIDY W. (contact);HERCE, MICHAEL EMMANUEL

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Address;Adherence;Africa;Africa South of the Sahara;AIDS prevention;cohort;Communities;Country;Criminal Justice;Data;Development;Eligibility Determination;emtricitabine;Enrollment;Epidemic;epidemic response;Funding;Future;Goals;Guidelines;Health;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;Imprisonment;Incidence;innovation;insight;interest;Intervention;Interview;Justice;Knowledge;Left;low and middle-income countries;Measures;meetings;member;men;Methods;Motivation;North America;novel;Oral;Participant;Patient Self-Report;Pattern;Persons;point of care;Population;pre-exposure prophylaxis;preference;Prevalence;Prevention;prevention service;Prevention strategy;primary outcome;Prisons;prospective;Qualitative Research;Questionnaires;Research;Research Methodology;response;Risk;Risk Behaviors;Risk Factors;risk perception;Sampling;Seasons;secondary outcome;service delivery;Service delivery model;Social support;substance use;System;Tenofovir;Testing;theories;Time;United States National Institutes of Health;uptake;Urine;Visit;Work;Zambia

PROJECT_TITLE: Prison PrEP Values Adherence and Implementation in Lusaka (PrEVAIL)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE HIV pre-exposure prophylaxis (PrEP) is a cornerstone to ending HIV in the United States (US), but gaps in PrEP uptake expose regional and racial disparities; despite accounting for the majority of new HIV infections, PrEP use remains exceedingly low among young sexual and gender minorities (YSGM) in the US South. In North Carolina, the HIV epidemic is uniquely concentrated in more rural counties, presenting unique HIV prevention challenges including provider shortages, over-burdened health departments, intersectional stigmas, and lack of PrEP knowledge among providers and rural YSGM. In this project, we will partner with state and local health department sexually transmitted infection clinics to examine a multilevel intervention targeting PrEP use barriers at the policy, clinic, provider, and PrEP user levels, with the goal of increasing PrEP uptake and persistence among YSGM via an integrated, cost-effective, and scalable strategy.

PI_NAMEs: MUESSIG, KATHRYN E;RUTSTEIN, SARAH E. (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Accounting;Address;Adolescent;Adult;AIDS prevention;antiretroviral therapy;Area;Behavioral;Black race;budget impact;Caring;cis-female;Client;Clinic;Clinic Visits;Collaborations;Complement;Consensus;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;County;demographics;design;Development;digital health;Disparity;Effectiveness;effectiveness evaluation;effectiveness outcome;Eligibility Determination;Enrollment;Epidemic;Equity;evidence base;Financial Support;flexibility;Future;gender minority group;gender minority men;gender minority women;Geography;Goals;Health;Health Personnel;Healthcare;Heterogeneity;Heterosexuals;Hispanic;HIV;HIV diagnosis;HIV Infections;Human Resources;implementation evaluation;implementation fidelity;implementation outcomes;implementation science;implementation strategy;improved;Individual;Infection;Infrastructure;Insurance;Interruption;Intervention;intervention cost;intervention mapping;Knowledge;Link;male;Measures;meetings;metropolitan;Modeling;Newly Diagnosed;North Carolina;Participant;Pathway interactions;Patients;peer;peri-urban;Persons;Phase;Policies;Populations at Risk;Poverty;pre-exposure prophylaxis;prevention service;Prevention strategy;primary outcome;Process;prospective;Provider;racial disparity;Ramp;Randomized;randomized trial;Reporting;Resources;Risk;Route;Rural;rural area;rural counties;rural dwellers;Rural Health;rural patients;scale up;Services;sex;Sexual and Gender Minorities;sexual minority group;Sexually Transmitted Diseases;social stigma;Structure;success;support tools;syndemic;telehealth;tool;Training;transmission process;Underserved Population;United States;Update;uptake;Urban Health;Woman;Work

PROJECT_TITLE: Meet me where I am: A multilevel strategy to increase PrEP uptake and persistence among young sexual and gender minority men in rural NC


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE Navigation is an important daily skill that engages many sensory, motor and cognitive systems, but which can be severely impaired by aging and degenerative brain diseases. We propose to dramatically advance our understanding of the brain mechanisms mediating navigation by using high field fMRI to measure brain activity during a naturalistic driving task, and then analyzing these data by means of an innovative voxelwise modeling framework. The results will be used to test dozens of specific hypotheses about navigation, and to recover functional areas and networks that mediate this important process.

PI_NAMEs: GALLANT, JACK L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Aging;Animals;Area;Automobile Driving;Behavior;Brain;Brain Diseases;cognitive system;Computer Models;Data;Data Set;Destinations;Devices;Diagnosis;Environment;experimental study;Functional Magnetic Resonance Imaging;Goals;high dimensionality;Human;Image;improved;Individual;innovation;insight;Laboratories;Link;Literature;Location;Magnetic Resonance Imaging;Measurable;Measures;Mediating;Methodology;Methods;Modeling;Monitor;Motor;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;neuromechanism;neurophysiology;pathological aging;Pathway Analysis;predictive modeling;Process;Publications;Publishing;Quality of life;Research;Resolution;Rodent;Route;Sensory;Series;Signal Transduction;skills;System;Testing;Veins;virtual environment;virtual world;way finding;Work

PROJECT_TITLE: Representation of navigational and driving-related information across human brain

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Statement of Relevance to Public Health To date, the SARS CoV-2 pandemic has resulted in over half a million deaths in the US alone. Although effective vaccines are now available, there are limited therapeutic options for patients who develop life-threatening COVID-19. The SCARLET trial is a blinded, placebo-controlled, and randomized Phase 1 dose-ranging and safety study with an adaptive design in adult COVID-19 patients with ARDS, which will confirm that administration of the liponucleotide citicoline every 12 hours by i.v. bolus is safe in this vulnerable population and will provide preliminary evidence that citicoline has clinical efficacy in COVID-19 patients with ARDS.

PI_NAMEs: CROUSER, ELLIOTT D (contact);DAVIS, IAN CHRISTOPHER

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;Admission activity;Adult;Adverse effects;Age;Alveolar;alveolar type II cell;American;Anti-viral Agents;Antiinflammatory Effect;Appalachian Region;Attenuated;Autopsy;Biological Markers;Biology;Biometry;Blinded;Blood;Bolus Infusion;Bypass;Caring;Cell Physiology;Cells;Cessation of life;China;Clinic;Clinical;clinical center;clinical efficacy;Clinical Sciences;Clinical Trials;Clinical Trials Design;Consent;Coronavirus;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;Critical Care;Critical Illness;Cytidine Diphosphate Choline;Data;Data Analyses;Death Rate;design;Development;Dexamethasone;Dose;Drug Kinetics;efficacy outcomes;efficacy trial;Enrollment;Ethnic Origin;Europe;Experimental Models;Functional disorder;Gases;Gender;high risk;Hospitalization;Hour;Human;human subject;Hygiene;Hypoxemia;Hypoxemic Respiratory Failure;Immune;Impairment;improved;improved outcome;indexing;Infection;Infection Control;Inflammation;Inflammation Mediators;Influenza A virus;K-18 conjugate;Lecithin;Long COVID;Lung;Lung Compliance;lung injury;Measurement;Measures;Mechanical Ventilators;medical countermeasure;Medicine;Mus;mutant;Names;novel;Organ failure;Outcome;Outcome Measure;Oxygen;participant enrollment;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Pharmacologic Substance;Phase;Phase I Clinical Trials;phase II trial;Phospholipids;Placebo Control;Population;Pre-Clinical Model;prevent;primary outcome;Procedures;Production;Public Health;pulmonary function;Pulmonary Inflammation;Randomized;receptor;research clinical testing;Research Personnel;Resources;Risk;Safety;safety study;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;severe COVID-19;sex;Slice;small molecule;Social Distance;socioeconomics;study population;Survivors;Testing;Therapeutic;TMPRSS2 gene;tocilizumab;Transgenic Mice;Translational Research;underserved minority;Universities;vaccine acceptance;Vaccines;ventilation;Viral;Virus;Virus Diseases;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Supplemental Citicoline Administration for Reduction of Lung Injury Efficacy Trial (SCARLET)


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Peptides have extraordinary potential as therapeutics for a wide range of conditions, yet their extremely short half-lives in biological environments hamper clinical implementation prospects. Attaching peptides to polymer chains or physically encapsulating peptides within polymer particles can prolong peptide half-life and even improve biological function, however some polymer-peptide formulation designs can render peptide therapeutics less active. Towards fully leveraging the tunability of polymers to maximize clinical benefits of therapeutic peptides, this proposal describes a systematic investigation of how the molecular design of polymer-peptide formulations impacts the biophysical properties that influence biological function, including size, morphology, surface charge, stability, and binding affinity to biological targets.

PI_NAMEs: LETTERI, RACHEL  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Optimizing therapeutic peptide presentation within polymers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-F(55)]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Organ Transplantation;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Retinal degeneration (RD) affects both photoreceptors and retinal pigment epithelium (RPE). This study will determine whether transplants of a human embryonic stem cell (hESC)-derived retina together with a supporting layer of RPE promote better visual improvement than transplant of hESC-retina alone by using an RD rat model with dysfunctional RPE that does not reject human cells. In addition, we will investigate the mechanism of visual improvement with hESC- retinal transplants by creating RD rats with labels that identify specific host cells and investigating host-transplant connectivity.

PI_NAMEs: SEILER, MAGDALENE J (contact);THOMAS, BIJU BLAVADY

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;advanced disease;Affect;Age related macular degeneration;Allografting;Blindness;calmodulin-dependent protein kinase II;cell replacement therapy;cell type;Cells;Chronic;clinical application;Collaborations;college;CRISPR/Cas technology;Defect;Disease;efficacy evaluation;Ethics;Eye;eye regeneration;fetal;Fetal Tissues;Functional disorder;functional improvement;Genetic Engineering;Goals;Human;human embryonic stem cell;human embryonic stem cell transplantation;immunodeficiency;improved;improved outcome;Inherited;innovation;innovative technologies;insight;Label;Lead;Light;Modeling;monolayer;mouse model;mutant;nerve stem cell;neural;Neural Retina;neuron regeneration;Neurons;novel;organoid transplantation;Organoids;Outcome;Patients;Phase II Clinical Trials;photoreceptor degeneration;photoreceptor progenitor;Photoreceptors;Pigment Epithelium;Population;preclinical study;Process;Rattus;Recovery;Recovery of Function;repaired;Reporter;response;Retina;retina transplantation;retinal damage;Retinal Degeneration;retinal neuron;retinal progenitor cell;Retinitis Pigmentosa;rho;Rhodopsin;Rodent Model;Role;Source;stem cell differentiation;stem cell therapy;Stem cell transplant;Structure of retinal pigment epithelium;Surgeon;Synapses;Technology;Testing;Tissue Donors;Tissue Engineering;Transplantation;Vision;Visual;Visual Acuity;Visual System

PROJECT_TITLE: Integration and functionality of retinal organoid transplants


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Ethnic/racial minority populations are underrepresented in the biomedical research workforce. To address the nation’s efforts to diversify the scientific workforce and create a multidisciplinary national pool of investigators to conduct research addressing health disparities, we propose a strong research training program at Meharry with qualified, energetic and committed faculty and a career development curriculum that will facilitate their entry in biomedical research careers.

PI_NAMEs: MARTIN, PAMELA M (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: medical schools

PROJECT_TITLE: G-RISE at Meharry Medical College

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurosciences;Sleep Research

ORG_CITY: NORTHRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: PROJECT NARRATIVE This study will contribute to our fundamental understanding of the molecular basis of sleep need, by investigating the signaling pathways that relay demand for cellular repair to organismal sleep pressure. As this relay involves signaling components that are dysregulated in cancer, these studies are expected to be of broad relevance to human health.

PI_NAMEs: VAN BUSKIRK, CHERYL LYNN (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Alleles;Behavior;Behavioral;Binding;Biological Assay;Biological Models;Caenorhabditis elegans;career;cell injury;Cells;Cellular Stress;Communities;Cysteine;Data;Defect;Dependence;Development;Disease;Drosophila genus;Epidermal Growth Factor;Epidermal Growth Factor Receptor;experience;extracellular;Family;Genetic;genetic analysis;Genetic Models;Genetic Research;Genetic Screening;Goals;Growth Factor Overexpression;Health;Hispanic-serving Institution;Human;human disease;Immunoglobulins;Inflammation;innovation;insight;Integral Membrane Protein;interest;Knock-out;Knowledge;Ligands;Lobular Neoplasia;Malignant Neoplasms;Mammals;Membrane;Metalloproteases;Modeling;Molecular;Molecular Genetics;mutant;Mutation;Nematoda;Neuregulins;Neurons;Organogenesis;Orthologous Gene;overexpression;Pathway interactions;Peptide Hydrolases;Phenotype;pressure;Process;Productivity;programs;promoter;receptor;Receptor Protein-Tyrosine Kinases;repaired;Research;Research Personnel;response;Role;Schizophrenia;Science;Signal Pathway;Signal Transduction;Sleep;Sleeplessness;Source;Stress;Students;Tissues;tool;Training;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;Veins;Vulva;Zebrafish

PROJECT_TITLE: Exploring the function and shedding of a potential C. elegans Neuregulin


ADMINISTERING_IC: MH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed Center is aimed at advancing our understanding on the role of higher order thalamus in cognition. Higher order thalamus is perturbed in schizophrenia, which may contribute to cognitive impairments and leading symptoms. Gaining a mechanistic understanding of thalamic function and interactions with cortex will be fundamental for developing therapeutic interventions that will target higher order thalamus in severe cases of schizophrenia.

PI_NAMEs: KASTNER, SABINE  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Anatomy;Animal Model;Animals;Area;Attention;Basal Ganglia;Behavior;Behavioral;Brain;Brain Diseases;Brain imaging;Cell Nucleus;Cells;Cerebral cortex;Cognition;Cognitive;cognitive control;cognitive process;Communication;Communities;Computer Models;Computing Methodologies;Data;Data Collection;data sharing;Decision Making;Diagnosis;Disease;disease model;Dissection;Dorsal;Education and Outreach;Electrodes;Electrophysiology (science);Elements;Etiology;executive function;extrastriate visual cortex;frontal lobe;Glues;Goals;Human;human disease;Image;imaging study;Impaired cognition;Impairment;insight;Link;Macaca;Macaca mulatta;Maps;Medial Dorsal Nucleus;Memory;Methods;Modeling;multimodality;neglect;neural;neural circuit;neuroimaging;Neurons;nonhuman primate;Office of Administrative Management;Optics;optogenetics;Output;Parietal Lobe;Patients;Perception;Performance;Play;Positioning Attribute;Primates;Property;Prosencephalon;Pulvinar structure;Regulation;Research Personnel;response;Role;Route;Schizophrenia;Seminal;Sensory Process;Shapes;Stimulus;Structure;Symptoms;Thalamic Nuclei;Thalamic structure;theories;Therapeutic Intervention;Training Activity;Translating;transmission process;Tupaia;Tupaiidae;ventral visual stream;Visual attention;Visual Cortex;Visual System

PROJECT_TITLE: Cognitive Thalamus


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

PROJECT_TERMS: Annual Reports;Appointment;Behavioral;Brain;Budgets;Clinical;Cognition;Cognitive;Communication;Communities;community center;Computer Models;Consultations;data exchange;data sharing;Development;Education and Outreach;Electrophysiology (science);Focus Groups;Fostering;Goals;Human;imaging modality;Institution;Knowledge;Leadership;Link;Maintenance;meetings;Methods;Modeling;multimodal neuroimaging;multimodality;nonhuman primate;outreach;outreach program;Population;Postdoctoral Fellow;public education;Research Personnel;Resource Allocation;Resource Development;Resource Sharing;Role;Structure;Students;success;synergism;Thalamic structure;Training;training opportunity;Training Programs;Tupaiidae;Underrepresented Minority;United States National Institutes of Health;videoconference;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Dissemination and Implementation Research;Hearing Loss;Mental Health;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The Eleanor M. Saffran Conference on Cognitive Neuroscience and Rehabilitation of Communication Disorders provides a forum for researchers, teachers, students, clinicians, people with communication disorders and their care partners for an exchange of ideas that promotes translation of basic and clinical research in communications disorders to evidence-based rehabilitation practices in the clinic or school settings.

PI_NAMEs: MARTIN, NADINE  (contact);REILLY, JAMES JOSEPH

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adoption;Adult;Affect;Apraxia;aural rehabilitation;Award;Basic Science;bench to bedside;Budgets;Caregivers;Caring;Charge;Child;Childhood;Client;Clinic;Clinical;clinical application;clinical implementation;clinical practice;Clinical Research;Cochlear implant procedure;Cognition Disorders;cognitive neuroscience;cognitive rehabilitation;Communication;Communication impairment;deaf;Development;Diagnostic;Dimensions;disability;Discipline;Disease;Education;Educational workshop;Effectiveness;Ethnic Origin;evidence base;Evidence based practice;experience;Faculty;Feedback;Fostering;Future;hands on instruction;hard of hearing;health care disparity;Health Occupations;Health Services Accessibility;Human;Hybrids;implementation barriers;implementation process;implementation research;implementation science;improved;Individual;Inequity;innovation;interest;Intervention;Knowledge;Laboratories;Language;Language Disorders;Learning;Life;Linguistics;Manuals;meetings;Mission;Modeling;Modernization;motor control;multidisciplinary;neural;Neurology;Neuropsychology;Neurosciences;novel strategies;Participant;patient engagement;Patients;Personal Satisfaction;Persons;Population;Postdoctoral Fellow;posters;Process;programs;Psychology;psychosocial;Qualifying;Race;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;Resource Sharing;response;Schools;Science;Scientist;Socioeconomic Factors;Special Education;Speech;Speech Disorders;Speech-Language Pathology;stem;Stream;Structure;student training;Students;success;symposium;teacher;theories;Transcend;Translating;Translational Research;Translations;Travel;Treatment Protocols;undergraduate student;Voice;Work

PROJECT_TITLE: The Eleanor M. Saffran Conference on Cognitive Neuroscience of Rehabilitation of Communication Disorders

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

PI_NAMEs: USREY, W MARTIN (contact)

PROJECT_TERMS: Address;Affect;analytical tool;Animal Model;Animals;Area;area V1;Attention;attentional control;Automobile Driving;Axon;behavior measurement;Behavioral;behavioral study;Biological Assay;biophysical model;Brain;Brain imaging;Cerebral cortex;Cognition;Cognitive;cognitive control;cognitive task;Communication;Complement;Data;Decision Making;Disease;Electrodes;Ensure;Environment;experimental study;extrastriate visual cortex;Frequencies;Human;human disease;imaging approach;Laboratories;Lateral;Mediating;Mediator;Modeling;Monkeys;Neurons;neurotransmission;operation;optogenetics;Output;Pathway interactions;Periodicity;Peripheral;Play;Positioning Attribute;Process;Property;Pulvinar structure;Regulation;response;retinotopic;Role;Sensory;sensory cortex;Sensory Process;Shock;Signal Transduction;Stimulus;Structure;Synapses;synergism;Testing;Thalamic Nuclei;Thalamic structure;Toes;Translating;Visual Cortex

PROJECT_TITLE: Pulvinar cellular and network dynamics in cognitive control of sensory processes.


ORG_CITY: SHREVEPORT

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The COBRE Center for Applied Immunology and Pathological Processes (CAIPP) provides a unique interactive training and research environment for investigators to receive mentorship and guidance, while increasing the competitiveness of their research programs for national funding. The proposed Center will allow the development and growth of the key infrastructure needed to support the national competitiveness of not only the members of the CAIPP Center, but of all researchers on campus, the region and the state. We propose new techniques and infrastructure not presently found on campus. We also propose to promote the interaction and synergy of multiple disciplines where appropriate and harness the collective strengths of the collaborative departments and schools within the state and region to drive research competitiveness. Together, the CAIPP will advance new insights and understanding for how when the immune system is dysregulated in either a hyperactive manner as would be seen in the case of chronic inflammatory conditions or when negatively affected such as during infection with viral or bacterial pathogens, serious and often fatal disease pathologies ensue. It is the understanding of the molecular and clinical basis for these diseases and resulting immunopathologies that we hope will lead to new and better ways to detect and treat these various diseases. These proposed studies go hand and hand with the needs of the citizens of the State of Louisiana where diseases associated with altered immune responsiveness take a significant toll on the health of the citizens of the state, as well as financially on the health care system within the state.

PI_NAMEs: YUROCHKO, ANDREW D (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: adaptive immune response;Address;Adult;Advisory Committees;Affect;Age;Anti-viral resistance;Antibiotics;Area;Arthritis;Bacterial Infections;Basic Science;Bone remodeling;Cardiovascular system;cell growth;Cell Nucleus;Cell Physiology;Cells;Centers of Research Excellence;Cessation of life;Chlamydia;Chronic;chronic inflammatory disease;Clinical;Collaborations;Communicable Diseases;Core Facility;Data;Death Rate;Development;Discipline;Disease;effective therapy;Embryonic Development;Environment;Equipment;experience;Faculty;faculty research;Fostering;Foundations;Functional disorder;Funding;Future;Goals;Gonorrhea;Grant;Growth;Growth and Development function;Hand;Health;Health Sciences;Healthcare Systems;Heart Diseases;HIV;Home;Host Defense;Human;human disease;Human Resources;Hyperactivity;Immune;immune function;Immune response;Immune system;Immunology;immunopathology;Immunophenotyping;Immunotherapy;improved;Individual;Infection;Infection Control;Infectious Agent;Inflammatory;Infrastructure;Innate Immune Response;insight;International;Leadership;Louisiana;Malignant Neoplasms;member;Mentors;Mentorship;Mission;Modeling;Molecular;Neonatal;novel therapeutics;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Pathologic Processes;Pathology;Play;Prevention;Process;Program Development;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Rest;Role;Schools;Science;Scientific Advances and Accomplishments;Sexually Transmitted Diseases;Site-Directed Mutagenesis;Specialist;statistics;success;synergism;Syphilis;Teacher Professional Development;Techniques;Therapeutic Intervention;tool;Training;Training Programs;translational potential;tumor;United States;Universities;Viral;Virus Diseases;wound healing


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Although HIV self-testing (HIVST) can reach men who have sex with men at high risk of HIV infection, most MSM who remain at risk are never linked to care and even fewer initiate pre-exposure prophylaxis (PrEP) after testing, highlighting a major gap in the HIV prevention continuum. We seek to close this gap by developing and piloting a peer-led linkage to PrEP intervention after HIVST, with the goal of increasing PrEP uptake among MSM at risk of HIV. The proposed research will optimize the impact of HIVST among MSM, an evidence-based tool to expand HIV testing, while expanding the prevention continuum through linkage to PrEP to reduce new HIV infections in this key population.

PI_NAMEs: BIEN-GUND, CEDRIC HOWSHAN (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Adopted;Affect;AIDS prevention;antiretroviral therapy;Behavior;behavior change;Behavior Therapy;Behavioral;career;Caring;Clinical Trials Design;Collaborations;Complement;County;COVID-19;COVID-19 pandemic;Cross-Sectional Studies;Data;Decentralization;design;Development;effectiveness-implementation RCT;effectiveness/implementation hybrid;effectiveness/implementation trial;Epidemic;Evaluation;evidence base;Feedback;Goals;Health behavior;Health Professional;Health system;high risk men;HIV;HIV diagnosis;HIV Infections;HIV/STD;Human immunodeficiency virus test;Hybrids;implementation measures;implementation outcomes;implementation science;implementation strategy;Individual;innovation;Intervention;intervention mapping;intervention refinement;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Life Experience;Link;Measures;men who have sex with men;Mentors;Methodology;Methods;Motivation;novel;novel strategies;patient oriented;peer;Persons;Philadelphia;pilot test;Population;pre-exposure prophylaxis;prevent;Prevention;Preventive care;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;remote health care;Research;Research Personnel;Risk;Risk Reduction;Self Efficacy;self testing;service delivery;Services;skills;social stigma;Social support;Target Populations;Testing;testing uptake;theories;therapy design;tool;Training;Treatment Efficacy;Underserved Population;uptake

PROJECT_TITLE: Promoting linkage to PrEP after HIV self-testing through a peer-led intervention for MSM

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Arthritis;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Achievement;Address;Advisory Committees;Area;Arthritis;Basic Science;Benchmarking;Budgets;Businesses;Cancer Center;Cells;Cellular biology;Centers of Research Excellence;Clinical Sciences;Collaborations;Communication;Consult;Core Facility;Data;Development;Discipline;Disease;Education;education research;Educational workshop;Evaluation;Event;experience;Faculty;faculty research;Functional disorder;Funding;Goals;Grant;Growth;Health Sciences;Immune;Immune response;Immune System Diseases;Immunology;immunopathology;Individual;Infrastructure;infrastructure development;Institution;International;Leadership;Learning;Link;Medicine;meetings;member;Mentors;Mentorship;Microbiology;Molecular;Monitor;Otolaryngology;Pathogenesis;Pathologic Processes;Pathology;Pharmacology;Physiology;Policies;Positioning Attribute;Principal Investigator;Procedures;professor;Program Development;programs;recruit;Report (document);Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rheumatology;Schedule;Schools;Services;Specialist;synergism;Teacher Professional Development;tenure track;Time;Touch sensation;Training;Training Programs;Translational Research;tumor;United States National Institutes of Health;virology;web page;web site;Writing


PROJECT_TERMS: analytical tool;Anatomy;Animals;Anterior;Area;association cortex;Attention;Behavior;Behavioral;Cell Nucleus;cingulate cortex;Cognition;Cognitive;cognitive control;cognitive function;cognitive process;Collaborations;Complement;Computer Models;Data;data quality;data structure;Decision Making;directed attention;Disease;Environment;executive function;experience;experimental study;frontal eye fields;Glues;Human;Individual;innovation;Investigation;Knowledge;lateral intraparietal area;Learning;Lesion;Macaca;Maps;Measures;Medial Dorsal Nucleus;Memory;Modeling;Monkeys;Mus;neural;neuroimaging;nonhuman primate;novel strategies;operation;Outcome;Output;Parietal Lobe;Pattern;Perception;Play;Population;Prefrontal Cortex;Primates;Process;Property;Pulvinar structure;response;Role;Sensory;sensory gating;sensory input;Short-Term Memory;Signal Transduction;Stimulus;Testing;Thalamic Nuclei;Thalamic structure;Training;transmission process;Tupaiidae;Uncertainty;Vision;Visual attention;Work

PROJECT_TITLE: Functions and thalamocortical interactions of macaque higher order thalamus in cognitive control


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: NARRATIVE The proposed experiments described herein will examine the influence of repetitive element transcription on sensitivity to ATRi as a cancer treatment and identify new combination treatment strategies for prostate cancer.

PI_NAMEs: BROWN, ERIC J (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: advanced prostate cancer;Affect;androgen independent prostate cancer;ATM Gene Mutation;BRCA2 gene;cancer cell;cancer therapy;CDC2 gene;Cell Line;Clinical;Combined Modality Therapy;Complex;Cyclin A;Defect;derepression;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Polymerase III;DNA replication fork;DNA Replication Inhibition;DNA Sequence;DNA Structure;DNA Synthesis Inhibition;Double Strand Break Repair;Drug Synergism;efficacy testing;endonuclease;Etiology;Exhibits;experimental study;Fostering;Frequencies;Gene Silencing;Generations;Genetic Predisposition to Disease;Genetic Transcription;Genome;genomic locus;Genomics;Histones;Hybrids;inhibitor;Location;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methylation;Minisatellite Repeats;Molecular;mouse model;Multienzyme Complexes;Mutation;novel;Pharmaceutical Preparations;Play;premature;prostate cancer cell;Prostate Cancer therapy;RB1 gene;Repetitive Sequence;Retroelements;RNA;RNA Processing;Role;Short Interspersed Nucleotide Elements;Site;Structure;Sulfamethoxazole;synergism;Testing;Therapeutic;TP53 gene;treatment strategy;tumor;tumor growth

PROJECT_TITLE: Effect of DNA repeat silencing on efficacy of ATRi in prostate cancer treatment

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Metabotropic glutamate receptors (mGluRs) are neuromodulatory G protein-coupled receptors with critical roles as drug targets for neurological and psychiatric diseases. We propose here to characterize the structural and biophysical bases of their regulation by beta-arrestins and how this complex interaction shapes mGluR pharmacology, signaling and trafficking at the synapse.

PI_NAMEs: LEVITZ, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Architecture;Arr2;ARRB1 gene;base;beta-arrestin;Binding;Binding Sites;Biological;Biological Assay;biophysical techniques;Biophysics;C-terminal;Calorimetry;cell cortex;Cell Line;Cells;Complex;Coupling;Cryoelectron Microscopy;Data;desensitization;Dimensions;dimer;Dimerization;Drug Targeting;Electron Microscopy;Endocytosis;Esthesia;extracellular;Family;Family member;fluorescence imaging;G protein coupled receptor kinase;G-Protein-Coupled Receptors;genetic regulatory protein;GTP-Binding Proteins;Heterodimerization;Image;improved;In Vitro;Individual;insight;Ligand Binding Domain;Ligands;live cell imaging;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mediating;Membrane;Mental disorders;metabotropic glutamate receptor 2;metabotropic glutamate receptor 3;metabotropic glutamate receptor 8;Metabotropic Glutamate Receptors;Molecular;molecular imaging;Negative Staining;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neurophysiology;neuroregulation;neurotransmission;NMR Spectroscopy;Optics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphorylation;Physiological;presynaptic;prevent;Process;Property;Proteomics;receptor;Receptor Activation;Receptor Down-Regulation;receptor downregulation;Regulation;Resistance;Resolution;response;Role;scaffold;Shapes;Signal Transduction;Signaling Molecule;Signaling Protein;single molecule;spatiotemporal;stoichiometry;Structure;Synapses;Techniques;Therapeutic;Time;Titrations;trafficking;Transducers;Work

PROJECT_TITLE: Mechanisms of Regulation of Metabotropic Glutamate Receptors

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Schizophrenia

PI_NAMEs: HALASSA, MICHAEL M (contact)

PROJECT_TITLE: Mechanistic dissection of cognitive thalamocortical engagement in attention and hierarchical reasoning.


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative  Non-invasive optical imaging is essential for understanding biological functions at the cellular or sub- cellular level. This project brings together an interdisciplinary team to develop the next generation microscopy techniques for imaging deep and fast within intact tissues and organs.

PI_NAMEs: NISHIMURA, NOZOMI ;WISE, FRANK W;XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: adaptive optics;Address;Adoption;Anatomy;Animal Model;Animals;Biological;Biological Process;biological systems;Biology;Biomedical Research;Blood capillaries;Body System;bone;Brain;Brain region;Cancer Biology;Cardiac;Cell Differentiation process;cell motility;Cell Physiology;Cells;Chronic;Color;cost;Data;Databases;daughter cell;design;Development;Dyes;experimental study;Face;Fiber;flexibility;Fluorescence Microscopy;fluorophore;Frequencies;frontier;Gases;Generations;Heart;Hippocampus;Image;imaging capabilities;Imaging Techniques;Immunology;improved;in vivo;Injury;instrument;Intestines;intravital imaging;Kidney;knowledge base;Label;Lasers;Location;lymph nodes;Mammary gland;Marrow;Measurement;Measures;mechanical load;Microscope;Microscopy;Mus;Muscle;neural;Neurosciences;new technology;next generation;non-invasive optical imaging;novel;Operative Surgical Procedures;Organ;Organ Model;Osteocytes;Penetration;Performance;Perfusion;Photons;Physiologic pulse;Preparation;Process;programs;Proteins;Protocols documentation;Research Activity;Resolution;scale up;Signal Transduction;Skeletal Muscle;Skin;Source;stem cell fate;Structure;System;Techniques;Testing;Time;timeline;Tissue imaging;Tissues;tumor;two photon microscopy;two-photon;Variant;Vision;Visualization;waveguide

PROJECT_TITLE: Toward fast and deep imaging of living tissue with cellular resolution

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SCOTT, RONA S (contact)

PROJECT_TERMS: Area;Behavior;Big Data;Bioinformatics;bioinformatics infrastructure;Biological;Centers of Research Excellence;Clinical Informatics;Complex;complex data;computer infrastructure;computer science;computerized tools;Data Analyses;Development;Disease;Education;Ensure;experience;Experimental Designs;Extramural Activities;Faculty;faculty research;Fee-for-Service Plans;Fostering;Funding;Future;Gene Activation;Gene Expression;Gene Proteins;Genes;Genetic;genetic predictors;genetic regulatory protein;Genomics;Goals;Healthcare;Hospitals;Human Resources;Immune response;Immunological Models;Immunologics;Immunology;Individual;Inflammation;Informatics;Infrastructure;innovation;Invaded;Knowledge;mathematical model;Mediator;meetings;Methods;Microarray Analysis;Modeling;Molecular;Mutation;network models;next generation sequencing;novel;Outcome;pathogen;Pathologic;Pathologic Processes;Pathway Analysis;Pathway interactions;Postdoctoral Fellow;Productivity;programs;Proteins;Proteome;Publications;Research;Research Activity;Research Personnel;Resources;response;Secure;Services;skills;Software Tools;Stimulus;student training;Students;success;System;Technical Expertise;Technology;Tissues;Training and Education;Training Programs;tumor;undergraduate student;Universities;virology;whole genome;Work

PROJECT_TITLE: Core B Modeling Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: Loma Linda

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: NARRATIVE Men of African ancestry have a higher incidence and mortality from prostate cancer (PCa) than men of European ancestry. There is currently an urgency to understand the molecular mechanisms underlying these race-related differences and to harness them for identifying novel therapeutic targets. The high mortality of advanced PCa is attributed to therapy resistance, thus there is also an urgent clinical need to develop innovative approaches to circumvent this resistance. The proposed study will uncover the molecular basis for specific race-related differences in PCa immunobiology, which could provide key insights into immune determinants contributing to PCa mortality disparities. The study will also establish the glycolytic enzyme Enolase as a potential therapeutic and theranostic target for advanced PCa, which could lead to innovative clinical strategies to reduce overall PCa mortality disparities.

PI_NAMEs: ALMAGUEL, FRANKIE G;CASIANO, CARLOS A. (contact);DAS, BHASKAR CHANDRA

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Active Sites;advanced prostate cancer;Affect;African ancestry;anti-tumor immune response;antitumor effect;Autoantibodies;Biological;Biological Markers;Biological Testing;Boron;cancer biomarkers;cancer gene expression;cancer health disparity;cancer immunobiology;Cell surface;Cells;Characteristics;Chemoresistance;Clinical;clinical effect;Clinical Research;design;Development;Diagnostic;Diagnostic Imaging;differential expression;Disparity;Effectiveness;enolase;Enzymes;European ancestry;FOLH1 gene;Future;Genes;Genetic;Homology Modeling;Image;Immune;Immune response;Immune Targeting;immunoreactivity;Incidence;Inflammatory;innovation;insight;Invaded;Lead;Libraries;Life Style;Malignant neoplasm of prostate;men;Metabolism;Metastatic Prostate Cancer;migration;Molecular;mortality;mortality disparity;nanomolar;Neoplasm Metastasis;neoplastic cell;neuroendocrine differentiation;new therapeutic target;novel;novel therapeutics;Organoids;Outcome;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Permeability;pharmacokinetics and pharmacodynamics;pharmacophore;Positron-Emission Tomography;Post-Translational Protein Processing;Pre-Clinical Model;Process;Proliferating;Property;prostate cancer cell;prostate cancer cell line;prostate cancer model;Prostatic Neoplasms;Protein Isoforms;Proteins;Race;racial difference;racial disparity;racial diversity;Radiolabeled;Radionuclide therapy;Resistance;response;Role;small molecule;small molecule inhibitor;socioeconomics;Specificity;Structure-Activity Relationship;Surface;Surface Antigens;taxane;Testing;theranostics;Therapeutic;therapy resistant;tomography;Toxic effect;transcriptome sequencing;tumor;Tumor Antigens;X-Ray Computed Tomography

PROJECT_TITLE: Role and Theranostics Potential of Enolase in Prostate Cancer Health Disparities


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: The National Institutes of Health have prioritized mentorship to support development of a diverse research workforce. Through building this global mental health research mentoring network based on the current scientific evidence of mentoring, we will connect senior researchers from around the world with select trainees and early career investigators, to better prepare them for successful research careers in global mental health including understanding and intervening upon social drivers of mental illnesses across the lifespan.

PI_NAMEs: KOHRT, BRANDON ALAN;WEINE, STEVAN MERRILL (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acceleration;Address;Affect;Area;Assessment tool;burden of illness;career;career development;Caring;Chicago;Cognitive;Collaborations;Colonialism;Communities;Competence;Complex;Development;Development Plans;Discrimination;early-career faculty;education research;Educational Activities;Engineering;Equity;evidence base;experience;Exposure to;Faculty;Fellowship;Foundations;Funding;Goals;Grant;Health Professional;Health Services Research;Homelessness;Illinois;improved;Individual;innovation;Institution;Institutional Policy;interest;International;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Learning;life span;Lived experience;low and middle-income countries;maltreatment;marginalized population;Measures;Medical;Medicine;member;Mental disorders;Mental Health;Mentors;Mentorship;Methods;minority communities;multidisciplinary;National Institute of Mental Health;National Research Service Awards;Network-based;Participant;Patient Self-Report;peer;peer networks;Persons;Play;Population;Postdoctoral Fellow;Poverty;Prevention;Productivity;professional students;Program Evaluation;programs;Provider;Publications;recruit;Reduce health disparities;Research;Research Personnel;Resource-limited setting;response;Role;Science;science, technology, engineering, mathematics, and medicine;Scientist;Self Administration;senior faculty;skills;social;social stigma;Strategic Planning;Structure;success;summer institute;theories;Time;tool;Training;Underrepresented Populations;UNHCR;UNICEF;United States National Academy of Sciences;United States National Institutes of Health;Universities;Violence;Washington;Wisconsin;Writing

PROJECT_TITLE: Mentoring Network for Global Mental Health Research on Social Drivers Of Mental Illnesses across the Lifespan (gmhCONNECT)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: COLLINS, ANNE G.E. (contact)

PROJECT_TITLE: Thalamocortical cognitive networks in the healthy human brain


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative Multi-drug resistant Klebsiella pneumoniae infections are a major threat to human health as we move into the 21st century. One of the defining characteristics of K. pneumoniae is a robust capsule that aids in resistance to the human complement system, host antimicrobial peptides, and last resort therapeutic polymyxins. This proposal will define the physiochemical attributes that allow for antimicrobial peptide penetration through capsule and provide direction for therapeutic development of antimicrobial peptides to inhibit the fatal infections caused by K. pneumoniae.

PI_NAMEs: FLEEMAN, RENEE  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adjuvant;alpha helix;Amino Acids;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;antimicrobial;Award;Bacterial Antibiotic Resistance;Bacterial Capsules;Bacterial Infections;beta pleated sheet;Binding;Biochemical;Biophysics;Bypass;capsule;Characteristics;Chemicals;Communicable Diseases;complement system;Data;Death Rate;design;Ensure;Excision;experimental study;Goals;Health;Host Defense;Human;immune clearance;Immune system;Infection;Innate Immune System;Klebsiella pneumoniae;Knowledge;Libraries;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Multi-Drug Resistance;mutant;Nature;novel;novel strategies;Penetration;peptide structure;Peptides;Phagocytosis;Phase;Polymyxins;Positioning Attribute;prevent;Process;Public Health;Research;Research Personnel;Resistance;resistant Klebsiella pneumoniae;Resources;Role;scaffold;Structure;Testing;Texas;Therapeutic;therapeutic development;Transmission Electron Microscopy;Universities;Variant;Virulence;Work

PROJECT_TITLE: Refining our understanding of antimicrobial peptide mediated disruption of the Klebsiella pneumoniae capsule

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project narrative Gut colonization by Klebsiella pneumoniae greatly increases the risk of acquiring a subsequent K. pneumoniae infection, which is a leading cause of hospital-acquired and highly antibiotic-resistant infections. This study will examine K. pneumoniae gut colonization to identify, characterize and prioritize targets for focused therapeutic intervention. Thus, the proposed research is directly relevant to the mission of NIH to enhance health, lengthen life, and reduce illness by contributing to the understanding of the first step in K. pneumoniae pathogenesis.

PI_NAMEs: VORNHAGEN, JAY  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;anti-microbial peptide;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Bacteremia;Bacteria;Bacterial Physiology;biological adaptation to stress;Biological Assay;carbapenemase;Categories;Cells;Citrate (si)-Synthase;Clinic;Complement;Data;density;design;Development;Disease;Ecology;enhancing factor;Extended-spectrum β-lactamase;fitness;Foundational Skills;gut colonization;gut microbes;gut microbiome;gut microbiota;Health;Hospitals;host microbiota;Human;In Vitro;Indigenous;Infection;infection risk;Inflammation;inflammatory milieu;innovation;Invaded;Investigation;Klebsiella pneumoniae;Knowledge;Libraries;Life;Mediating;member;Mentors;Metabolic;Michigan;microbial;microbial composition;microbial host;microbiome;microbiota;Mission;mouse model;Nosocomial pneumonia;novel;novel diagnostics;novel therapeutics;Operon;pathogen;Pathogenesis;Patients;Physiological;Pneumonia;Population;prevent;Process;Production;Public Health;Publications;Research;resilience;Resistance;response;Risk;Role;Stress;stress resilience;stress tolerance;System;Tellurium;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapy design;Training;transposon sequencing;United States National Institutes of Health;Universities;Urinary tract infection;Work

PROJECT_TITLE: Assessing Klebsiella pneumoniae invasion of the intact gut microbiome


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: WOOLARD, MATTHEW DALE (contact)

PROJECT_TERMS: Antibodies;Cardiovascular Diseases;Cells;Centers of Research Excellence;Communicable Diseases;Core Facility;Data;Development;Disease;Disease Progression;Ensure;Equipment;experience;Experimental Designs;experimental study;extracellular;Faculty;faculty research;Family;Flow Cytometry;Functional disorder;Funding;Generations;Goals;Health Sciences;Human Resources;Immunohistochemistry;Immunologics;Immunology;Immunophenotyping;In Situ Hybridization;Individual;Infectious Agent;Inflammation;Inflammatory Response;Infrastructure;Institution;Investments;Laboratories;Louisiana;Microscope;Microscopy;Neurologic Dysfunctions;novel;Pathologic Processes;Postdoctoral Fellow;programs;protein expression;protocol development;Protocols documentation;Reagent;Reproducibility;Research;Research Personnel;Resource Sharing;Rheumatoid Arthritis;Services;Students;success;Technical Expertise;Techniques;Technology;Testing;tool;Training;Training and Education;Training Programs;ultra high resolution;Universities;Work

PROJECT_TITLE: Core C Immunophenotyping


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PI_NAMEs: WOODWARD, NEIL D. (contact)

PROJECT_TERMS: Affect;Anatomy;Animal Model;Attention;attentional control;attentional modulation;Behavior;behavior measurement;Behavioral;Behavioral Model;Biological Markers;Brain;Cell Nucleus;Cognition;Cognitive;cognitive function;Conflict (Psychology);Cues;Data;Decision Making;density;Diffuse;Dissection;Dorsal;dorsal visual stream;effective intervention;Equilibrium;Exhibits;feature extraction;Fingerprint;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;graph theory;Human;Impaired cognition;Impairment;Individual;innovation;Intervention;Link;Maps;Medial Dorsal Nucleus;Methods;Mus;neural;Neurobiology;Neurosciences;Noise;nonhuman primate;optogenetics;Outcome;Pathway interactions;Patients;Pattern;Performance;Process;Property;Pulvinar structure;Regulation;Rest;Rodent;Role;Schizophrenia;Sensory;Signal Transduction;Structure;Symptoms;Testing;Thalamic structure;translational framework;Uncertainty;Variant;ventral visual stream;Visual;visual object processing;Visuospatial;Work

PROJECT_TITLE: Functional and behavioral dissection of higher order thalamocortical circuits in schizophrenia.


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Neuronal control of movement is extensively studied not only because it underlies fundamental human behaviors but also because neurodegenerative diseases that affect the motor system represent a significant burden for human health. We have identified abnormalities in the way neurons communicated with each other by means of abnormal removal of synaptic connections, which result in pathological situations. Additionally, we will be investigating the cellular and neuronal circuit mechanisms involved in postural and locomotor deficits since this proposal describes a multidisciplinary effort aimed to determine the molecular and cellular mechanisms that may contribute to human diseases such as spinal muscular atrophy—the leading genetic cause of death in infancy.

PI_NAMEs: MENTIS, GEORGE Z (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Affect;Afferent Neurons;Age;Anatomy;Autopsy;Behavior;Behavior assessment;Behavioral;Behavioral Assay;Biological Assay;brain pathway;Breathing;Cause of Death;CD47 gene;Cells;Central Nervous System;Classical Complement Pathway;clinically relevant;Communication;Complement;Complement 1q;Data;Defect;Deglutition;design;Development;Disease;disease model;dopaminergic neuron;Excision;Excitatory Synapse;experimental study;Functional disorder;Gait;Gene Mutation;Genes;Genetic;Health;Human;human disease;Impairment;improved;Induced Mutation;Infant;Infant Mortality;Inherited;insight;Interneurons;Knock-out;Knowledge;Levodopa;Link;Locomotion;locomotor deficit;Mediating;Mediator;Molecular;Morphology;Motor;motor behavior;motor deficit;motor impairment;Motor Neurons;Motor output;mouse genetics;mouse model;Movement;multidisciplinary;Mus;Muscle;Musculoskeletal Equilibrium;neural circuit;Neurodegenerative Disorders;Neuromuscular Diseases;neuron loss;neuronal circuitry;Neuronal Dysfunction;Neurons;neuroregulation;neurotransmission;Outcome Assessment;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Peripheral;pharmacologic;Pharmacological Treatment;Phenotype;Physiological;Posture;Process;Property;Proteins;PTPNS1 gene;receptor;Research;restoration;Role;Serotonin;Shapes;skeletal muscle wasting;SMN deficiency;SMN protein (spinal muscular atrophy);SMN1 gene;Spinal;Spinal Muscular Atrophy;spinal reflex;Spinocerebellar Tracts;Symptoms;Synapses;synergism;System;Testing;Tissues;TP53 gene;Translating;Trees;Viral;Work

PROJECT_TITLE: Mechanisms of Central Synaptic Dysfunction in SMA

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of intraocular vascular disorders such as wet AMD, but there is an urgent need to discover longer-acting VEGF inhibitors in order to reduce the burden of intravitreal injections. We hypothesized that the ability to bind heparan-sulfate proteoglycans in the vitreous may be a strategy to promote intraocular retention and lead to a longer half-life. We designed a series of VEGF receptor 1 variants and identified some with strong heparin-binding characteristics that are more effective and durable in animal models of intraocular neovascularization than a standard of care such as aflibercept. .

PI_NAMEs: FERRARA, NAPOLEONE  (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Affinity;Age related macular degeneration;Angiography;Animal Model;bevacizumab;Binding;Biological Assay;Blindness;Cattle;Cell Proliferation;Cells;Characteristics;Choroidal Neovascularization;Clinical;Clinical Trials;Complementary DNA;Data;design;Development;Disease;Endothelial Cells;Endothelial Growth Factors Receptor;experimental study;Extravasation;Exudative age-related macular degeneration;Eye;Half-Life;Heparan Sulfate Proteoglycan;Heparin;Heparin Binding;Human;In Vitro;in vivo;in vivo Model;inhibitor;Injections;intravitreal injection;Lasers;Life;Modeling;Mus;neovascularization;novel;Optical Coherence Tomography;Oryctolagus cuniculus;Outcome;Oxygen;Patients;Pharmaceutical Preparations;pre-clinical;Property;ranibizumab;Recombinant Proteins;Retinal Diseases;retinal ischemia;Rodent;Series;standard of care;Testing;TNFSF15 gene;Toxicology;Transfection;Treatment Factor;Variant;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;VEGFA gene;Vision;Visual Acuity

PROJECT_TITLE: Novel Long-Acting Inhibitors of Vascular Endothelial Growth Factor (VEGF) for Treatment of Intraocular Vascular Disorders

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Schizophrenia

PI_NAMEs: KOPELL, NANCY  (contact)

PROJECT_TERMS: Acetylcholine;Affect;Anatomic Models;Animal Model;Attention;Behavior;behavior prediction;Behavioral;behavioral outcome;Biological;biophysical model;Biophysics;Brain;cell type;Cells;Cognition;Cognitive;cognitive control;Cognitive deficits;Complex;Computer Models;Coupled;Cues;Data;Decision Making;Detection;Dimensions;Environment;Equation;experimental study;Frequencies;Functional disorder;Future;Glutamates;Hodgkin-Huxley model;Human;Impaired cognition;information gathering;Learning;Medial Dorsal Nucleus;Methodology;Modeling;Motivation;Motor Neurons;neural;Neuromodulator;Neurons;neuroregulation;nonhuman primate;novel;Output;Patients;Performance;Periodicals;Periodicity;Phase;Physiological;Physiology;Play;Primates;Property;Pulvinar structure;response;Reticular Cell;Role;Sampling;Schizophrenia;Sensory;sensory input;sensory integration;Signal Transduction;spelling;sustained attention;synergism;Testing;Thalamic Nuclei;Thalamic structure;Theta Rhythm;Time;Tupaiidae;Uncertainty;Variant;Visual;visual motor;Work

PROJECT_TITLE: Computational Core


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE This study will define the potential of interventions based on the removal of CD8+ lymphocytes to disrupt virus latency and reduce the reservoir that persists under antiretroviral therapy in SIV/SHIV-infected rhesus macaques. We will build upon our previously published data and use a highly relevant, well validated animal model to provide novel, critical information on how the recently-discovered latency promoting activity of CD8+ lymphocytes can be manipulated in vivo to reduce or eliminate the persistent virus reservoir under ART.

PI_NAMEs: SILVESTRI, GUIDO  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Anatomy;Animal Model;Animals;antiretroviral therapy;Apoptosis;Apoptotic;Autopsy;Bar Codes;BCL2 gene;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Combined Modality Therapy;Data;design;Excision;Genetic Transcription;HIV;HIV Infections;Human;Immunity;In Vitro;in vivo;Individual;Induction of Apoptosis;Infection;inhibitor;Interleukin-15;Interruption;Intervention;Location;Lymphocyte Depletion;Macaca;Macaca mulatta;Maintenance;Measures;Mediating;mimetics;Modeling;Natural Killer Cells;Nature;neutralizing antibody;novel;Primates;Production;Publishing;Research;Research Personnel;Resources;Role;Science;Shock;simian human immunodeficiency virus;SIV;Source;Suicide;T-Lymphocyte Subsets;Testing;Tissues;Universities;Viral;Viral reservoir;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Antiviral role of CD8+T cells in ART-treated SIV-infected macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: Horizontal gene transfer (HGT) by conjugation is one of the main contributors to the worldwide spread of antibiotic resistance. The proposed work will develop a novel, synthetic-biology-based intervention strategy for targeted suppression or elimination of self-transmissible plasmids. This strategy has two major implications: (1) addressing the rising antibiotic resistance crisis, by limiting their spread; (2) providing a toolkit for precision microbiome engineering through the modulation of gene flux.

PI_NAMEs: YOU, LINGCHONG  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Acceleration;Address;Affect;Antibiotic Resistance;Antibiotics;Bacteria;bacterial resistance;Biota;Cells;Chemicals;Clinical;design;Elements;Engineering;Exclusion;experimental analysis;experimental study;Foundations;Gene Exchanges;Genes;Genetic;Genetic Materials;Genome;Horizontal Gene Transfer;host microbiota;insight;Intervention;Invaded;Libraries;Maintenance;Mediating;Metabolic;microbial;microbial community;microbiome;Mobile Genetic Elements;Modeling;novel;operation;Partner in relationship;pathogen;pathogenic bacteria;Plasmids;Play;Population;Process;Protocols documentation;Resistance;Role;Sequential Treatment;synthetic biology;System;Testing;trait;treatment optimization;Treatment Protocols;treatment strategy;Virulence Factors;Work

PROJECT_TITLE: Targeted control of self-transmissible plasmids by using engineered interfering plasmids

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Poly(ADP)-ribose polymerase inhibitors (PARPi) exemplify a promising therapeutic strategy for the treatment of homology-repair deficient tumors. The proposed research is relevant to public health as elucidation of the cellular DNA repair mechanisms that respond to PARPi treatment will enable novel approaches to combat clinical issues of resistance and relapse. Successful completion of the proposed research will advance the NIH mission to improve human health by providing the framework for the development of new therapeutics for the treatment of BRCA and homology-repair deficient malignancies.

PI_NAMEs: JENSEN, RYAN BROWN (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Agreement;Alleles;Binding;Biochemical;Biological;Biological Assay;brca gene;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Bypass;cancer cell;Cancer Patient;cancer therapy;Cell Death;Cell model;Cells;Cellular Assay;Clinical;Clinical Management;combat;Complex;Coupled;cytotoxicity;Data;Development;DNA;DNA Binding;DNA Damage;DNA fiber assay;DNA Repair;DNA replication fork;DNA Structure;Drug Design;drug sensitivity;EMSA;Event;Excision;Exhibits;FDA approved;Filament;Gene Mutation;gene repair;genome integrity;Germ-Line Mutation;Goals;Health;Human;improved;In Vitro;Individual;inhibitor therapy;innovation;insight;Invaded;Knowledge;Laboratories;Lesion;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Mission;Modeling;Molecular;mutant;Mutation;novel;novel strategies;novel therapeutics;nuclease;Nucleoproteins;Pathogenicity;patient response;Patients;Play;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Process;protein purification;Proteins;Public Health;Reaction;reconstitution;recruit;Relapse;relapse patients;repair function;repaired;Research;Resistance;resistance mechanism;responders and non-responders;response;Role;single molecule;single-molecule FRET;Single-Stranded DNA;skills;superresolution microscopy;System;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;tool;Toxic effect;TRAP Complex;treatment strategy;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: Defining the Roles of BRCA2 and RAD51 in PARPi Response

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

ORG_CITY: ATHENS

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative The burden of tuberculosis is disproportionately borne by low- and middle-income countries of sub-Saharan Africa, such as Uganda. The current proposal is built upon the premise that digital mobile technologies, that were not developed with health purposes in mind, may be leveraged in imaginative and novel ways to provide useful information that could guide the prevention and control of tuberculosis transmission, infection, and disease. The proposed training program will build research capacity among a community of scientists to enable them to apply new technologies and analytic methods to study an old disease like tuberculosis.

PI_NAMEs: SEKANDI, JULIET NABBUYE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Adherence;Africa;Africa South of the Sahara;Artificial Intelligence;Cause of Death;Cellular Phone;Clinical;Complex;computer science;Data;Databases;Dedications;digital;digital health;digital technology;Discipline;Disease;Disease Management;effective therapy;Enrollment;Ensure;Epidemiology;Geography;Goals;Health;Health Technology;Infection;low and middle-income countries;Machine Learning;Measures;Metadata;Methods;Mind;mobile computing;Modernization;multidisciplinary;novel;Outcome;Persons;pre-doctoral;prevent;programs;Research;Research Design;Research Personnel;Research Project Grants;Science;Scientist;Short-Term Course;skills;Societies;Southeastern Asia;Students;symposium;Technology;Training;transmission process;Treatment Protocols;Tuberculosis;Uganda;Universities;World Health Organization

PROJECT_TITLE: Digital Mobile Technologies to study Tuberculosis: A Multi-disciplinary Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: CHEN, ZHE SAGE (contact)

PROJECT_TERMS: analytical tool;Animals;Attention;attentional control;Behavioral;Brain;Brain Diseases;Brain region;Cognition;Cognitive;cognitive control;Collaborations;Communication;Communities;Complex;Computer Models;Computer software;Data;Data Analyses;Data Analytics;data archive;data curation;data format;data pipeline;Data Set;data sharing;Decision Making;Dedications;Documentation;Electrophysiology (science);executive function;Functional Magnetic Resonance Imaging;Glues;high standard;Human;human imaging;human-in-the-loop;Image;Individual;innovation;Lead;Link;Machine Learning;machine learning method;meetings;Methods;Modeling;Monkeys;multimodal data;multimodality;Multivariate Analysis;National Institute of Mental Health;neural;neuroimaging;Neurons;neuroregulation;Neurosciences;Play;Population;Postdoctoral Fellow;Primates;Process;Publications;Pulvinar structure;Pythons;Recording of previous events;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Role;Source;statistical and machine learning;statistics;Structure;Techniques;Testing;Thalamic Nuclei;Thalamic structure;theories;tool;tool development;Travel;Tupaiidae;virtual;web site

PROJECT_TITLE: Data and Analytical Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases

PI_NAMEs: DRAGOI, ANA-MARIA  (contact)

PROJECT_TERMS: Actins;adaptive immune response;Adherence;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Anus;Apoptosis;Bacteria;bacterial resistance;Betaproteobacteria;Bioinformatics;carcinoembryonic antigen-related cell adhesion molecules;Cells;Cephalosporin Resistance;Cicatrix;Coupled;Cytoskeleton;design;Development;Disease;Environment;Epithelium;Etiology;extracellular;fluoroquinolone resistance;Frequencies;Genetic Materials;Genetic Transcription;Genitalia;Genitourinary system;Gonorrhea;Growth;Half-Life;Human;Immune response;Immune system;Immunology;Immunophenotyping;in vivo;Incidence;Infection;Innate Immune Response;Innate Immune System;Invaded;Investigation;Left;lipooligosaccharide;Lysosomes;Macrophage;major outer membrane protein;Mammalian Oviducts;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Nasopharynx;Neisseria gonorrhoeae;neutrophil;new therapeutic target;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathologic Processes;Pathology;Pathway interactions;Pelvic Inflammatory Disease;Phagocytes;Phase;Pilum;Play;polymerization;Polymers;Process;Protein Family;Proteins;Public Health;reproductive tract;Role;Sexually Transmitted Diseases;Site;symptomatology;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptional reprogramming;Vaccines;VDAC1 gene;White Blood Cell Count procedure;Woman;Work

PROJECT_TITLE: Contribution of macrophages to Neisseria gonorrhoeae pathogenesis


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Obesity is a major risk factor for osteoarthritis that involves both mechanical (altered joint loading) and biological (systemic inflammation) components, but the interaction between altered mechanosensation and obesity-related inflammation is unclear. The goal of this proposal is to determine if chondrocyte mechanotransduction via the Piezo ion channels is altered by obesity-associated inflammation. These findings will provide key mechanistic insights into the pathogenesis of osteoarthritis that can be more broadly developed into novel therapeutic strategies.

PI_NAMEs: ELY, ERICA VALENTINE (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Address;adipokines;Affect;aggrecan;American;Animal Model;Animals;Antibodies;Atomic Force Microscopy;Attenuated;behavior test;Biological;Biomechanics;Body fat;bone;Calcium;Calcium ion;Calcium Signaling;Cartilage;Cations;Cell Death Inhibition;cell type;Cells;Cessation of life;Chondrocytes;chondroprotection;Circulation;Complement;Confocal Microscopy;cytokine;Degenerative polyarthritis;Development;disability;Disease;Esthesia;experience;Exposure to;Fatty acid glycerol esters;Gene Modified;Goals;graduate student;Harvest;Health;healthy weight;High Fat Diet;High Prevalence;Hindlimb;Histology;Homeostasis;human model;Hypersensitivity;Imaging Techniques;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;insight;Interleukin-1 alpha;Interleukin-6;Ion Channel;joint injury;joint loading;Joints;Knee joint;knock-down;Knock-out;Length;Leptin;Link;Maintenance;Measurement;Measures;mechanical force;mechanical load;Mechanical Stress;Mechanics;mechanotransduction;Medial meniscus structure;medical specialties;meniscus injury;Messenger RNA;microCT;Modeling;Monitor;mouse genetics;mouse model;Mus;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Pain;Pathogenesis;Pathologic;Pathway interactions;Pharmaceutical Preparations;Physiological;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;protein expression;Proteins;response;Risk Factors;Role;Scanning Probe Microscopes;sensor;Serum;Signal Transduction;Synovial Fluid;Synovial joint;systemic inflammatory response;Testing;therapeutic target;Tissues;TNF gene;Training;Transgenic Mice;Translating;Trauma;Traumatic Arthropathy;Up-Regulation;Western Blotting

PROJECT_TITLE: The Multiscale Role of Piezo Channels in Obesity-Associated Cartilage Damage


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cocaine use disorder increases the risk of HIV infection and HIV infection increases cocaine use, suggesting that these conditions share important reciprocal interactions such that each can exacerbate the other; however, the molecular and cellular bases for cocaine-HIV interactions are poorly understood. Here, we will use cutting- edge single-cell sequencing, single-cell epigenetics, and spatially resolved transcriptomics technologies to characterize transcriptional responses to HIV infection and/or volitional cocaine consumption in a cell type- specific manner in addiction-relevant brain regions of mice, to determine the functional interactions between cocaine use in HIV infection and these cell type-specific transcriptomic profiles. This program of research promises to deliver maps of brain gene expression relevant to cocaine addiction and HIV infection with unprecedented cellular resolution.

PI_NAMEs: KENNY, PAUL J.;VOLSKY, DAVID J;ZENG, HONGKUI  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;antiretroviral therapy;Archives;Autopsy;base;Behavior;Behavioral;behavioral response;Biological Assay;Brain;brain cell;Brain Mapping;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chromatin;Chromium;Chromosome Mapping;Chronic;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;cohort;Consumption;Corpus striatum structure;Coupled;Data;Data Set;deep sequencing;Development;Disease;Environment;Epigenetic Process;epigenome;epigenomics;Evaluation;experience;Fluorescent in Situ Hybridization;foot;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;Genetic Markers;Genetic Transcription;Goals;Habenula;Hand;HIV;HIV Infections;HIV Seronegativity;HIV-1;HIV-associated neurocognitive disorder;Human;Human immunodeficiency virus test;Image;Immunocompetent;Individual;Infection;innovation;insight;Intake;Intervention;Intravenous;Lateral;Maps;Measures;methamphetamine exposure;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Mus;National NeuroAids Tissue Consortium;Neurobiology;Neuroglia;Neurology;Neurons;neuropathology;Neurosciences;Opioid;opioid exposure;Outcome;overdose death;Pathologic;Persons;Pharmaceutical Preparations;Positioning Attribute;Prefrontal Cortex;Procedures;programs;Property;Punishment;Research;Research Personnel;Resistance;Resolution;Resources;response;Rewards;Risk;Risk Factors;RNA;Sampling;Shock;single cell sequencing;single nucleus RNA-sequencing;Site;synergism;Technology;Testing;Tissue Donors;Tissues;Training;transcriptome;transcriptomics;Validation;virology;XCL1 gene

PROJECT_TITLE: Single cell transcriptomic and epigenomic changes during chronic HIV infection and cocaine self-administration


NIH_SPENDING_CATS: Genetics

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Narrative The cohesin protein complex bridges together the copies of chromosomes following DNA replication, and compacts chromosomes by forming intramolecular loops and domains. These activities ensure accurate chromosome segregation during cell division, and allow proper DNA repair, gene expression and development. Our work will address how cohesin function is integrated with DNA replication, and how changes in cohesin function within the nucleus are controlled to respond to local or cellular signals.

PI_NAMEs: RANKIN, SUSANNAH  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Cell division;Cell Nucleus;Cells;Chromosome Segregation;Chromosomes;cohesin;cohesion;Cultured Cells;Development;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;egg;Embryo;Ensure;Eukaryota;Funding;Gene Expression;genetic approach;Genetic Transcription;Genome;In Vitro;Maintenance;Mediating;Modeling;Modification;Molecular;Molecular Genetics;Nuclear Structure;Orthologous Gene;Outcome;Peptide Initiation Factors;Play;Process;protein complex;protein purification;Proteins;Rana;Regulation;Role;Signal Transduction;Sister Chromatid;Site;System;Testing;Vertebrates;Work

PROJECT_TITLE: Mechanisms of cohesin regulation in vertebrates

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Vaccine Related

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

PI_NAMEs: GESTAL, MONICA CARTELLE (contact)

PROJECT_TERMS: Acellular Vaccines;adaptive immune response;adaptive immunity;airway immune response;Animal Model;Anti-Bacterial Agents;Antibodies;Antibody Formation;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Attention;Automobile Driving;B-Lymphocytes;Bacterial Antigens;Bacterial Infections;Biology;Bordetella;Bordetella bronchiseptica;Bordetella Infections;Cells;Child;chronic infection;cytokine;Data;Developed Countries;Developing Countries;Development;Disease;Emerging Communicable Diseases;eosinophil;Excision;Exhibits;expectation;experimental study;Failure;FDA approved;Flow Cytometry;Gastric mucosa;Generations;Goals;helminth infection;Helminths;Homeostasis;IL17 gene;Immune;Immune response;Immunity;Immunology;improved;In Vitro;in vivo;Incidence;Infection;Inflammatory;insight;Knowledge;Lower respiratory tract structure;Lung;Maintenance;Mediating;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Mucosal Immunity;Mucous Membrane;Mus;novel;Parasitic infection;pathogen;Pathologic Processes;Pathway interactions;Pertussis;Play;Production;recruit;respiratory;Respiratory Disease;respiratory pathogen;Respiratory System;Respiratory Tract Infections;response;Role;side effect;Signal Pathway;Signal Transduction;Stomach;Streptococcus pneumoniae;T cell differentiation;T cell response;T-Cell Activation;T-Lymphocyte;Testing;therapy development;transcriptome;transcriptome sequencing;vaccine access;vaccine strategy;Vaccines;Whole Cell Vaccine;Work

PROJECT_TITLE: Eosinophils facilitate bacterial clearance by mediating antibacterial T cell responses in the respiratory tract


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: JANGRA, ROHIT K (contact)

PROJECT_TERMS: Address;Americas;Biology;Cardiopulmonary;Case Fatality Rates;Containment;Development;FDA approved;genetic analysis;Glycoproteins;Hantavirus;Hantavirus Infections;Hemorrhagic Fever with Renal Syndrome;high throughput analysis;Human;Immune response;Immunology;Mediating;Molecular;novel;Pathologic Processes;Persons;Plasmids;Public Health;Research;reverse genetics;Rodent;Role;South American;Surface;Syndrome;System;transmission process;Vaccines;Virion;Virus

PROJECT_TITLE: Development of a novel BSL2 system for high-throughput analysis of hantavirus entry glycoproteins


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because increasing our understanding of continence-regulating neural circuits and bladder-afferent-activity sensing circuits, both of which function critically within the reflex micturition pathway, is ultimately expected to increase understanding of the neural control of bladder function and of how urinary continence is maintained. As such the proposed research is relevant to the part of the NIH and NIDDK missions that pertains to developing fundamental knowledge that may yield improved pharmacologic approaches and interventional strategies, and thereby reduce the burdens of human disability, in not only individuals with brain or spinal cord injury-induced LUTS, but also in aging and a host of neurodegenerative disorders, including Parkinson's disease.

PI_NAMEs: VERSTEGEN, ANNE ("HANNEKE") (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Affect;Afferent Neurons;Aging;Axon;Behavior;Bladder;Bladder Control;Brain;brain control;Brain region;burden of illness;Cells;Clinical;clinical development;Communication;Conceptions;Data;Development;disability;Elderly;Environment;executive function;experience;Fiber;Future;Goals;Human;Hypothalamic structure;Image;improved;in vivo;Individual;inhibitory neuron;innovation;Intervention;Knowledge;Label;lower urinary tract symptoms;Maps;Micturition Reflex;midbrain central gray substance;Mission;Molecular;Motor Neurons;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;nerve supply;neural;neural circuit;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuroregulation;novel;novel therapeutics;optogenetics;Outcome;Output;Paper;Parkinson Disease;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Photometry;Play;Pontine structure;Population;predictive modeling;Preoptic Areas;presynaptic;prevent;Process;Public Health;Publishing;Reflex control;Research;Role;Sacral spinal cord structure;Sensory;Signal Transduction;Site;social;Source;Spinal Cord;Spinal cord injury;Stretching;Symptoms;Synapses;Testing;therapeutic target;United States National Institutes of Health;Urethral sphincter;Urination;Work

PROJECT_TITLE: Bladder fullness signaling and the neural control of continence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Pain Research;Palliative Care

PHR: PROJECT NARRATIVE Palliative care is effective for improving quality of care for nursing home residents with Alzheimer’s Disease and Related Dementias (ADRD), but there are few sustainably-designed and tested models for nursing homes and palliative care practices to implement. The UPLIFT-AD (Utilizing Palliative Leaders In Facilities to Transform care for Alzheimer’s Disease) intervention provides both internal capacity-building strategies for nursing homes, as well as external specialty palliative care support, to impact the overall quality of care for residents with ADRD. Impact on quality of care of residents with ADRD near the end of life will be measured, as well as success of the implementation of the intervention and nursing home staff palliative care knowledge.

PI_NAMEs: CAGLE, JOHN GARLAND;UNROE, KATHLEEN T (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adoption;Advance Care Planning;advanced dementia;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Attitude;Caring;Cessation of life;Complex;Consult;Dementia;design;Diagnosis;Discipline of Nursing;Education;effectiveness evaluation;Eligibility Determination;end of life;Environment;Evaluation;Exposure to;Family;Family member;Family Nursing;Goals;Health system;Home Nursing Care;hospital readmission;Hospitals;Hybrids;Impaired cognition;implementation context;implementation evaluation;implementation intervention;improved;Incentives;Indiana;Individual;Industry;instrument;Intervention;Knowledge;Long-Term Care;Maryland;Measures;medical specialties;Modeling;Motivation;nursing care quality;Nursing Education;nursing home length of stay;Nursing Homes;Nursing Models;Outcome;Pain management;palliative;Palliative Care;Patients;person centered;Persons;programs;Quality of Care;Quality of life;Randomized;rapid growth;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research Priority;Rewards;satisfaction;Site;Standard Model;success;surrogate decision maker;Surveys;symptom management;Symptoms;Testing;Training;Translations;trial design

PROJECT_TITLE: UPLIFT-AD (Utilizing Palliative Leaders in Facilities to Transform care for Alzheimer's Disease) intervention

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: Over activity of the brain renin-angiotensin system (RAS) has major deleterious effects in the development and maintenance of cardiovascular diseases (CVD), particularly in hypertension, which affects 55% of individuals above age 55 in United States. Based on our previous work, ADAM17-mediated shedding is a novel and unexplored mechanism leading to a loss of compensatory ACE2 (angiotensin converting enzyme type 2) activity but also an increase in pro-inflammatory cytokines in hypertension and CVD. Targeting the maturation of ADAM17 will be investigated both in vitro and in vivo in order to determine the overall benefits for the treatment of hypertension.

PI_NAMEs: LAZARTIGUES, ERIC D (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: absorption;Affect;Age;aged;Aldosterone;Angiotensin II;Angiotensins;Autonomic Dysfunction;Blood Pressure;blood pressure reduction;Bone Marrow;Brain;Cardiovascular Diseases;Cardiovascular system;Cell membrane;Cells;clinically relevant;conditional knockout;CX3CL1 gene;cytokine;Data;Development;Disintegrins;DOCA;Drug Targeting;exosome;Experimental Models;Gene Deletion;Genetic Models;Genetically Engineered Mouse;Glutamates;Heart;Human;human stem cells;Hypertension;hypertension treatment;hypertensive;Hypothalamic structure;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Interleukin-6;Kidney;knock-down;Knockout Mice;Lead;Maintenance;Mediating;Medical;Metalloproteases;Microglia;Molecular;mortality;Mus;Nerve;neurogenic hypertension;neuroinflammation;Neurons;novel;Organ;overexpression;paraventricular nucleus;Peptidyl-Dipeptidase A;Physiological;Prevalence;prevent;Process;Proteins;Public Health;receptor;Regulation;Renin-Angiotensin System;Reporting;Resistance development;Resistant Hypertension;rhomboid;Risk Factors;Role;salt sensitive hypertension;Signal Transduction;Sodium Chloride;Stimulus;Synapses;Testing;Time;Tissues;TNF gene;Transgenic Organisms;United States;Up-Regulation;vasoconstriction;Vasopressins;Water;Work

PROJECT_TITLE: Targeting ADAM17 maturation in resistant hypertension.

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE  Overall Component Gary S. Stein and Janet L. Stein, Program Directors Building on a record of significant contributions, this highly collaborative program, pursued by a team of scientists and physician-investigators, will explore epigenetic mechanisms that regulate and respond to parameters of genome organization. The Program Project facilitates the conceptual and experimental integration required to advance understanding of functional parameters of epigenetic control that will provide novel insights into breast cancer onset and progression, and provide potential diagnostic and/or therapeutic value.

PI_NAMEs: STEIN, GARY S. (contact);STEIN, JANET L

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;advanced breast cancer;aggressive breast cancer;Animal Model;Architecture;ATP phosphohydrolase;Biochemical;Bioinformatics;Biological;Biometry;bone;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Bromodomain;cancer cell;Cancer Cell Growth;cancer diagnosis;cancer therapy;Carcinoma;cell growth;Cell model;cell transformation;Cells;Chromatin;chromatin remodeling;clinically relevant;Communication;Data Analyses;Data Set;design;Diagnostic;Dimensions;Endocrine;Ensure;Epigenetic Process;epigenome;epitranscriptomics;Estrogen receptor positive;experience;Experimental Designs;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genome;Genome Components;genome editing;genome-wide;Genomic approach;Genomics;Goals;hormonal signals;Hormone Responsive;hormone therapy;in vivo;in vivo Model;innovation;insight;Investigation;Leadership;Link;live cell imaging;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mediating;Mitotic;Modification;Molecular;multidisciplinary;new technology;Normal Cell;novel;novel strategies;Nuclear;Nuclear Structure;Oncologist;operation;Organoids;Pathologist;Patients;Phenotype;Physicians;Physiological;Process;programs;Proliferating;Proteins;Protocols documentation;public database;Reader;Regulation;Reproducibility;Research;Research Personnel;Resistance;Resource Sharing;Resources;response;Role;scientific organization;Scientist;Selective Estrogen Receptor Modulators;Seminal;Specimen;Standardization;synergism;Therapeutic;therapy resistant;Time;Tissues;transcription factor;Transcriptional Regulation;tumor;tumor progression;ultra high resolution;Untranslated RNA;Visualization

PROJECT_TITLE: Epigenetic Control and Genome Organization


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

PHR: PROJECT 1 | NARRATIVE Breast cancer is a leading cause of death for women in the United States and around the globe. An early event in development of breast cancer is the epithelial-to-mesenchymal transition (EMT) when mammary cells lose their normal structure and function and gain migratory and invasive properties. Project 1 studies will investigate mitotic gene bookmarking—mitotic retention of transcription factors with target genes on chromosomes for transcriptional regulation in progeny cells—as an epigenetic mechanism to maintain normal mammary epithelial cell identity. We will determine whether compromised mitotic bookmarking by the RUNX1 transcription factor results in initiation of EMT and onset of breast cancer. Findings will have far reaching impact on development of new approaches to identify and therapeutically target early events in breast cancer development.

PI_NAMEs: STEIN, GARY S. (contact)

PROJECT_TERMS: acute myeloid leukemia 1 protein;Biological;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Epithelial Cells;cancer cell;cancer initiation;Cause of Death;Cell division;Cell Line;Cell Proliferation;Cells;ChIP-seq;Chromatin;Chromosomes;Clinical;clinically relevant;Collaborations;CRISPR screen;Data;Development;Developmental Process;Dimensions;DNA Binding;Epigenetic Process;epigenome;Epithelial Cell Proliferation;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Equilibrium;Estrogen receptor positive;Estrogen Receptors;Estrogens;Event;Gene Expression;Genes;Genetic Transcription;Genome;Genomic approach;Genomic Segment;Genomics;Growth;Hi-C;histone modification;Histones;in vivo;innovation;Knowledge;Link;live cell microscopy;loss of function;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Neoplasms;Maps;Mediating;Mitosis;Mitotic;Mitotic Chromosome;Modeling;Molecular;Mutation;Neighborhoods;novel;novel strategies;nuclease;Outcome;pharmacologic;Phenotype;Physiological;Play;Precision Run-On Sequencing;preservation;prevent;programs;Property;Receptor Signaling;Regulation;Research Personnel;Resolution;Role;RUNX1 gene;Signal Transduction;Specimen;Structure;Supporting Cell;Testing;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome;tumor;tumor progression;United States;Validation;Women's mortality

PROJECT_TITLE: Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype