NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Nanotechnology;Rehabilitation

PI_NAMEs: MALECKIS, KASPARS  (contact)

PROJECT_TERMS: Adhesions;Age;Angiography;Animals;Anisotropy;Arteries;Biochemical;Biomechanics;Blood Platelets;Blood Vessels;Bypass;Cadaver;Cardiovascular system;Characteristics;claudication;Computer Models;Contralateral;critical limb Ischemia;cytotoxicity;Data;design;Development;Diameter;Disease;Elastic Fiber;elastomeric;Elastomers;Electrospinning;Endothelium;Engineering;Environment;Evaluation;Extracellular Matrix;Failure;Fiber;graft failure;healing;hemodynamics;Hip Joint;Histologic;Human;Hyperplasia;Implant;improved;in silico;In Situ;In Vitro;in vivo;Intervention;Knee joint;Legal patent;Ligaments;limb movement;Limb structure;Lower Extremity;manufacture;Measurement;Measures;mechanical properties;Mechanics;Methods;Modeling;nanofibrillar;novel;Pathologic Processes;Patients;Performance;performance tests;Perfusion;Periodicals;Peripheral arterial disease;peripheral blood vessel;Permeability;pharmacologic;Physiological;Play;Polymers;porcine model;pre-clinical;prevent;Prosthesis;prototype;reconstruction;Research;Resistance;response;Role;Rotation;Rubber;Sampling;Scanning Electron Microscopy;Speed;Stress;Stretching;Structure;Surgical sutures;Technology;Testing;Textiles;Thick;Tubular formation;ultrasound;Variant;Water;Work;X-Ray Computed Tomography

PROJECT_TITLE: Lower Extremity Bypass Graft With Physiologic Longitudinal Pre-Stretch


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Infectious Diseases;Nanotechnology;Prevention;Regenerative Medicine;Rehabilitation;Wound Healing and Care

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PI_NAMEs: SALKOVSKIY, YURY  (contact)

PROJECT_TERMS: absorption;Acceleration;Acetates;Affect;Age;Air;Air Movements;aldosterone hypertension;Angioplasty;Animals;Area;Biomechanics;Biopolymers;Blood flow;Burn injury;Bypass;capillary bed;Carbon Dioxide;Cardiovascular system;Characteristics;Chemicals;Cholesterol;chronic wound;Clinical;Clinical Trials;Cutaneous;Data;decubitus ulcer;Deoxycorticosterone;design;Development;diabetic ulcer;Diameter;Dorsal;Drops;Dryness;Economics;Electrodes;Electrospinning;Epidermis;Evaluation;evaporation;Excision;Exudate;Family suidae;Fiber;Film;Foot Ulcer;Future;Gases;Growth;healing;Health Care Costs;Hospital Costs;Human;Humidity;hypertensive;improved;in vivo;infection risk;Inflammation;Inflammatory;Ischemia;Lesion;limb amputation;Lower Extremity;manufacture;Measurement;Measures;Mechanics;Medical;Methods;microbial;microbiota;Modeling;nanofiber;Natural regeneration;novel;novel strategies;Operative Surgical Procedures;Outcome;Oxygen;Pathogenicity;Patients;Penetration;Performance;Perfusion;Periodicals;Peripheral arterial disease;Permeability;Persons;Polymers;porcine model;Porosity;Powder dose form;pre-clinical;Pre-Clinical Model;pressure;prevent;primary endpoint;Process;Property;Proteus mirabilis;Pseudomonas aeruginosa;Public Health;Quality of life;Recovery;regenerative;Regenerative capacity;regenerative tissue;Reperfusion Therapy;Research;Risk Reduction;secondary infection;Silicones;Skin;Social Impacts;Speed;Staphylococcus aureus;Sterile coverings;Streptococcus pyogenes;Structure;Surface;Talc;Testing;Thick;Thinness;tissue resource;Topical agent;traditional therapy;transmission process;Ulcer;vapor;Varicose Ulcer;Vascular blood supply;voltage;Water;water vapor;western diet;wound;wound care;wound dressing;wound healing;Wound Infection

PROJECT_TITLE: Effects of Wound Dressing's Vapor and Gas Permeability on Ischemic Ulcer Healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


ADMINISTERING_IC: DK

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Obesity has become increasingly prevalent in the United States, and this epidemic is a global health problem. The storage capacity of adipose tissue is an important link between excessive adiposity and the pathogenesis of numerous metabolic diseases, including the Metabolic Syndrome, Type 2 diabetes mellitus, and cardiovascular disease. The proposed research is relevant to public health because it will provide new insights into mechanisms that regulate human adipose tissue expansion, distribution, and function, which can greatly influence whole body health and metabolism.

PI_NAMEs: WHITE, URSULA  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Abdomen;Adipocytes;Adipose tissue;angiogenesis;Biopsy;Body Composition;Body Weight;Cardiovascular Diseases;Characteristics;Chronic;Closure by clamp;Control Groups;Data;Deposition;Deuterium;Disease;Dual-Energy X-Ray Absorptiometry;energy balance;Energy Intake;Epidemic;Extracellular Matrix;Fatty acid glycerol esters;feeding;Femur;Future;global health;Health;High Prevalence;Homeostasis;Human;Hyperplasia;Hypertrophy;Impaired health;Impairment;In Vitro;in vivo;in vivo evaluation;Individual;insight;insulin sensitivity;Intervention;Investigation;Kinetics;Knowledge;Label;Link;lipid biosynthesis;Lipids;Liver;Magnetic Resonance Imaging;Measures;men;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity associated disease;obesity development;Organ;Outcome;Overweight;Pathogenesis;Pathologic;Persons;Physiological;Population;post intervention;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;response;Risk;Risk Factors;Role;subcutaneous;Testing;Tissue Expansion;Triglycerides;United States;Visceral;Weight;Weight Gain;Woman

PROJECT_TITLE: Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Trichomonas vaginalis, the most common non-viral sexually transmitted infection worldwide, disproportionately affects African Americans and is associated with increased risk of HIV acquisition, adverse birth outcomes, infertility, and other adverse reproductive morbidities. Metronidazole is used for the treatment of trichomoniasis, but in up 10% of cases, T. vaginalis isolates are resistant. Results from the proposed studies will provide new knowledge about metronidazole resistance in T. vaginalis that will inform development of future assays for rapid metronidazole-resistance detection as well as novel drugs.

PI_NAMEs: GRAVES, KEONTE J (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 4-nitroimidazole;adverse birth outcomes;Affect;African American population;Alabama;Antioxidants;Appearance;Applications Grants;Area;Basic Science;Bioinformatics;Biology;Biometry;Candidate Disease Gene;candidate identification;candidate validation;career;career development;Categories;Cell Culture Techniques;Cell Death;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical Sciences;Clinical Trials;Communication;cytotoxic;Data;Data Set;design;Detection;detection assay;Development;differential expression;Diffusion;Disease;DNA biosynthesis;DNA Repair;Doctor of Philosophy;dosage;Dose;drug development;Enzymes;experimental study;FDA approved;Foundations;Funding;Future;gel electrophoresis;Gene Expression Profile;Gene Targeting;Genes;Genome;genomic data;Goals;Grant;HIV;improved;Infection;Infertility;knock-down;Knock-out;Knowledge;Knowledge acquisition;Laboratories;laboratory experience;Laboratory Research;Learning;Literature;Manuscripts;Medicine;member;Mentors;Metabolic Pathway;Metronidazole;Metronidazole resistance;national surveillance;novel;novel therapeutics;overexpression;Parasites;Pathway interactions;Patients;Pharmaceutical Preparations;Positioning Attribute;Predisposition;Preparation;Prevalence;Production;rapid test;reproductive morbidity;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;Resistance;Resistance development;resistance gene;resistance mechanism;Review Literature;Risk;RNA;RNA analysis;Role;Scientist;Sexual Health;Sexually Transmitted Diseases;side effect;skills;Small Interfering RNA;Solid;Surveillance Program;systematic review;Techniques;Testing;Time;Tinidazole;Training;Training Programs;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transfection;treatment duration;Treatment Failure;Trichomonas Infections;Trichomonas vaginalis;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Identification of Trichomonas vaginalis resistance targets to inform future drug development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-K(20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The autoimmune disease systemic lupus erythematosus (SLE) offers an unexpected new approach to treating glioblastoma multiforme (GBM), the most lethal and difficult to treat primary malignancy of the brain. Deoxymab- 1 (DX1) is a nuclear-penetrating lupus anti-DNA autoantibody that localizes to tumors, inhibits DNA repair, selectively kills DNA repair-deficient cancer cells and tumors, and in a pilot study was found to cross the blood- brain barrier (BBB) and have single agent activity against GBM in a patient-derived xenograft (PDX) mouse model. We believe DX1 has potential to be translated into a novel therapy for GBM, and propose to: 1) elucidate and enhance the mechanism of BBB penetration by DX1 in GBM, 2) use DX1 to exploit the vulnerability of GBM to DNA damage, and 3) develop DX1 as a drug delivery ligand for targeting GBM.

PI_NAMEs: HANSEN, JAMES E. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adenosine;aggressive therapy;Agonist;Antinuclear Antibodies;Area;Autoantibodies;Binding;Biometry;Biophysics;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain endothelial cell;cancer cell;Cardiotoxicity;Cell Nucleus;Cells;chemotherapy;Clinical;Clinical Trials;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Inhibition;Dose;Double Strand Break Repair;Drug Delivery Systems;drug development;Drug Kinetics;efficacy evaluation;Encapsulated;Engineering;Environment;Evaluation;experience;experimental study;extracellular;Foundations;Genetic;Genetic Heterogeneity;Glioblastoma;Growth;Human;Immunocompetent;Immunodeficient Mouse;improved;in vivo;innovation;Intercellular Junctions;Ligands;Lupus;Malignant Neoplasms;Methods;Modeling;mortality;mouse model;Mus;Mutation;nanocarrier;neoplastic cell;neuro-oncology;Normal Cell;novel;novel strategies;novel therapeutics;Nuclear;Nucleoside Transporter;Nucleosides;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Penetration;Pharmaceutical Preparations;pharmacologic;Pilot Projects;PTEN gene;Purinergic P1 Receptors;Radiation;Radiation therapy;Radiation-Sensitizing Agents;Relapse;Research Personnel;restoration;Risk;risk minimization;Role;Site;standard of care;stem-like cell;Surface;systemic autoimmune disease;Systemic Lupus Erythematosus;Technology;Testing;Toxic effect;Translating;tumor;tumor growth;uptake;Work

PROJECT_TITLE: Targeting Glioblastoma with a Nuclear-penetrating Anti-DNA Autoantibody

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_DEPT: PHYSIOLOGY

PHR: Voltage-gated ion channels (VGICs) are responsible for electrical impulses in cells of the brain, heart and other tissues. We will use innovative electron cryo-microscopy techniques to obtain near-atomic-resolution structures of two VGICs in their resting and active states. This will provide an unprecedented view of the mechanism by which they control the electrical currents of ions.

PI_NAMEs: SIGWORTH, FREDERICK J (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Arabidopsis;brain cell;Buffers;Chimera organism;Complex;Cryoelectron Microscopy;Detergents;Drug Targeting;Equilibrium;Erythromelalgia;Funding;heart cell;Hereditary Disease;Heterogeneity;Human;innovation;interest;Ion Channel;Ion Channel Gating;Ion Channel Protein;Ions;Kv1.2' channel;Ligands;Light;Lipids;Membrane Potentials;Methodology;Methods;Molecular Conformation;mutant;Mutation;nanodisk;nanometer;Pain Disorder;pain sensation;particle;Pathway interactions;Positioning Attribute;Potassium Channel;Proteins;reconstitution;Relaxation;Resolution;Rest;sensor;Sodium Channel;Structure;Techniques;Time;Tissues;Vesicle;voltage;Work

PROJECT_TITLE: Fluctuations in Ionic Current through Membrane Channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Diabetes;Endocrine Disruptors;Estrogen;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Diabetes occurs in over 10% of the U.S. population, but little is known about the regulation of the mechanisms that develop within the fetus that promote insulin action after birth. This research proposal puts forth a highly innovative and novel concept and paradigm shift that a defect in skeletal muscle vascular development and function originating in the fetus precedes the onset of insulin resistance after birth in the offspring. A very new concept is also proposed that estrogen in utero has an essential role in developing the microvessel network in fetal skeletal muscle required for promoting insulin action and glucose homeostasis in offspring.

PI_NAMEs: ALBRECHT, EUGENE D. (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: 3 year old;4 year old;8 year old;Acute;Adherens Junction;Adipose tissue;Adult;angiogenesis;Aromatase;Aromatase Inhibitors;arteriole;Beds;Biological Assay;Biological Availability;Birth;Birth Weight;Blood capillaries;blood glucose regulation;Blood Vessels;Body Weight;brachial artery;Carrier Proteins;Cell Proliferation;Cells;clinically significant;contrast enhanced;Defect;density;Development;Developmental Process;Diabetes Mellitus;Disease;Electron Microscopy;Endocrine Disruptors;Endothelial Cells;Estrogen Receptors;Estrogens;Etiology;Event;Exhibits;Experimental Models;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;Fetal Skeleton;Fetus;Foundations;Functional disorder;Glucose;Glucose Intolerance;glucose metabolism;Glucose Transporter;glucose uptake;Growth;Health;Human;in utero;in vivo;Incidence;indexing;Injections;innovation;Insulin;Insulin Receptor;Insulin Resistance;insulin secretion;insulin sensitivity;Intravenous Bolus;Ischemia;Laboratories;Letrozole;Ligation;Liver;Mediating;Microbubbles;Morphology;Mutation;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel;null mutation;offspring;Pancreas;Papio;Phase;Placenta;Population;postnatal;postnatal development;Pre-Eclampsia;Pregnancy;Premature Birth;prenatal exposure;prepuberty;Primates;Process;Production;Proteins;Puberty;Receptor Signaling;Regulation;Research;Research Proposals;Role;Scientific Advances and Accomplishments;Skeletal Muscle;Study models;Technology;Testing;Therapeutic;Tight Junctions;Time;Tissues;ultrasound;Vascular Diseases;Vascular Endothelial Cell;Vascular System;VEGFA gene;X-Linked Ichthyosis

PROJECT_TITLE: Estrogen Regulation of Fetal Microvessel Development During Primate Pregnancy: Impact on Insulin Sensitivity in Offspring

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Spinal cord injury (SCI) affects 1.3 million Americans. The proposed experiments in this application are relevant to public health because they will elucidate mechanisms for how neuronal activation promotes axon growth, thus identifying potential therapeutic targets. Additionally, they will test whether neuronal activation – alone or in combination with other manipulations – promotes functional axon regeneration after SCI.

PI_NAMEs: TOM, VERONICA JEAN (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acetylation;Adult;Affect;American;Automobile Driving;Axon;axon growth;axon regeneration;Back;Behavioral;Central Nervous System;Cervical spinal cord injury;Chondroitin ABC Lyase;Chondroitinases;Cicatrix;Clozapine;constitutive expression;Crush Injury;Cytoskeleton;Data;designer receptors exclusively activated by designer drugs;Digestion;Disparate;dorsal column;Environment;experimental study;Fostering;FRAP1 gene;Genetic;Goals;gray matter;Growth;Guanosine Triphosphate Phosphohydrolases;improved;In Vitro;in vitro Model;in vivo;Injury;Kinesin;knock-down;Lead;Length;Mediating;Methods;Microtubules;Modeling;Motor;Multiple Trauma;Natural regeneration;Neurons;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oxides;Peripheral Nerves;permissiveness;Play;Population;Proteins;Public Health;Ras homolog enriched in brain;Recovery;Recovery of Function;Recurrence;repaired;response;Role;Sensorimotor functions;Sensory;Spinal;Spinal Cord;Spinal cord injury;Spinal Ganglia;spinal nerve posterior root;Structure;Synapses;Testing;Therapeutic;therapeutic target;Transplantation

PROJECT_TITLE: Multipronged approach to promote functional axonal regeneration in the spinal cord after injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(03)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance/Narrative Brains have evolved to process and store information from the outside world and do so through synaptic connections among interconnected networks of neurons. Our work will illuminate higher-order genome folding as an unexplored dimension of the long-range epigenetic control governing neuronal activation in the mammalian brain. Synaptic defects underlie many neurological disorders, therefore understanding the molecular mechanisms governing activity-dependent expression is of tremendous importance toward our knowledge of how neural circuits are disrupted in brain disease.

PI_NAMEs: PHILLIPS-CREMINS, JENNIFER ELIZABETH (contact);SHEPHERD, JASON D

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;addiction;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Bipolar Disorder;Brain;Brain Diseases;CCCTC-binding factor;Cell Nucleus;cell type;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computational Biology;CRISPR interference;CRISPR-mediated transcriptional activation;Defect;Detection;Dimensions;Disease;Electrophysiology (science);Elements;Embryo;Engineering;Enhancers;Environment;Epigenetic Process;epigenome;experience;FOS gene;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;genome editing;genome-wide;genomic locus;Genomics;Guide RNA;Hi-C;high dimensionality;Hippocampus;Hour;imaging study;Immediate-Early Genes;In Vitro;in vivo;Individual;innovation;interest;Kinetics;Knowledge;Link;long term memory;Mammalian Cell;Maps;mathematical model;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;Mus;Nervous System Disorder;neural;neural circuit;Neurobiology;Neurons;Pathway interactions;postmitotic;predictive modeling;Process;Protein Binding Domain;Proteins;public health relevance;Research Personnel;Resolution;response;Role;Schizophrenia;Single Nucleotide Polymorphism;Slice;spatiotemporal;stem;Stimulus;Structure;Synapses;Synaptic plasticity;synaptogenesis;Testing;Time;ultra high resolution;Up-Regulation;Work;YY1 Transcription Factor

PROJECT_TITLE: Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Racial and ethnic diversity in cancer genetics and genomics research is limited, despite the observation of differences in genomic contributions to cancer health disparities in certain racial and ethnic groups. This lack of diverse genomic data limits the ability to implement genetic risk assessment and management in minority groups and can lead to genetic misdiagnoses in all populations (including non-minority groups). The proposed research will contribute diverse genomic data for prostate cancer, for which African genomic information is limited.

PI_NAMEs: REBBECK, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;African;African American;African ancestry;Age;American;Biological;Biological Factors;Cancer Etiology;cancer genetics;cancer genomics;cancer health disparity;cancer risk;cancer therapy;Caribbean region;Characteristics;Clinical;Clinical Data;Critical Care;Data;Data Set;Death Rate;Development;Diagnosis;Disease;Disease Management;Disparity;Early Diagnosis;Ensure;Environmental Risk Factor;epidemiologic data;Epidemiology;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;European;European ancestry;experience;Gene Expression;Genetic;Genetic Predisposition to Disease;genetic risk assessment;genetic variant;Genetic Variation;GENIE;genomic data;Genomics;Germ Lines;Germ-Line Mutation;health care availability;Histopathology;improved;Incidence;Inequity;Infrastructure;Inherited;innovation;International Agency for Research on Cancer;Knowledge;Location;Malignant neoplasm of prostate;Malignant Neoplasms;men;Minority Groups;Modeling;modifiable risk;Molecular;Molecular Profiling;molecular subtypes;mortality;Mutation;Obesity;Pathogenicity;Pathologic;Pathology;polygenic risk score;Population;predictive modeling;Prevalence;Prevention;Prostate;Prostate carcinoma;Prostatic Neoplasms;public database;Public Health;Race;racial disparity;racial diversity;racial population;Research;Resources;Risk;Risk Factors;Risk Management;Sampling;social;social health determinants;Source;Susceptibility Gene;The Cancer Genome Atlas;transcriptome;transcriptomics;treatment strategy;tumor;tumor progression

PROJECT_TITLE: Genomic Diversity of Prostate Cancer Across the African Diaspora

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Neurosciences

PHR: Mechanosensitivity is a fundamental physiological capacity which allows us to interact with the environment through the perception of mechanical force, but molecular and cellular mechanisms that contribute to the modulation of mechanotransduction and mechanosensitivity under normal, pathological or adaptive conditions remain to be fully elucidated. The objective of this proposal is to elucidate how mechanical force is perceived at the molecular level in rapidly-adapting mechanoreceptors. Insights gleaned from these studies will facilitate the development of pharmacological strategies to treat a range of neurological disorders associated with altered mechanosensitivity in humans.

PI_NAMEs: BAGRIANTSEV, SVIATOSLAV  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TITLE: Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative This work aims to elucidate structure and chemical reaction mechanisms of metalloenzymes using quantum chemistry methods to model x-ray absorption, x-ray emission, and optical spectroscopies. Understanding the intermediates involved in these reaction mechanisms is directly relevant to ATP synthesis, melanin produc- tion, and to understanding infantile genetic disorders such as ethylmalonic encephalopathy. The methods for computational x-ray spectroscopy that come from this work can be used in the study of metal metabolomics, e.g. alongside experimental x-ray analyses of human brain tissue in the study of Alzheimer's disease, which is known to present with increased metal dyshomeostasis in the brain.

PI_NAMEs: CARTER-FENK, KEVIN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: absorption;Active Sites;Address;Adopted;Affinity;Alzheimer's Disease;ATP Synthesis Pathway;Behavior;Benchmarking;Biochemical;Biochemistry;Biological Process;biological systems;Biology;Brain;brain tissue;California;career;Catalysis;chemical reaction;Chemicals;Chemistry;collaborative environment;Community Outreach;Computer Analysis;computer studies;Computing Methodologies;computing resources;Copper;cost;Coupled;Data;density;design;Development;Drug Targeting;Educational process of instructing;Educational workshop;electron density;electronic structure;Electrons;Encephalopathies;Environment;Enzymes;Equation;Equilibrium;Foundations;Future;Genetic Diseases;Geometry;graduate student;Grant;Head;Health;Human;improved;improved outcome;in vivo;infancy;insight;Investigation;Iron;Ligands;Light;Linear Accelerator Radiotherapy Systems;Link;Measurement;Melanins;Mentors;Metabolism;metabolomics;metalloenzyme;Metals;method development;Methods;Modeling;Modernization;molecular orbital;Monophenol Monooxygenase;Motion;novel;novel therapeutics;Optics;Outcome;Oxidases;oxidation;Oxidation-Reduction;Pathway interactions;Production;Proteins;Protocols documentation;quantum chemistry;Quantum Mechanics;Reaction;Reporting;Research;Research Personnel;Respiration;Roentgen Rays;Role;Science;Source;Spectrum Analysis;Structure;Synchrotrons;System;theories;Time;time use;Training;United States National Institutes of Health;Universities;Work;Writing;X ray spectroscopy

PROJECT_TITLE: Towards a Quantum-Mechanical Understanding of Redox Chemistry in Proteins


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Genetic variation in humans contributes to disease processes in both simple (one sequence leads to disease) and complex (multiple sequence variants lead to disease) ways. In this project, we will develop a toolkit of proteomics and computational methods to interrogate protein sequence variants found in the neurogenerative diseases: Ataxia Oculomotor Apraxia 2 (AOA2), Amyotrophic Lateral Sclerosis 4 (ALS4), and PontoCerebellar Hypoplasia (PCH). The development of these approaches will allow us to speed up the characterization of protein sequence variants found in patients with rare disorders with a goal of rapid identification of potential therapeutic avenues.

PI_NAMEs: MOSLEY, AMBER L. (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Algorithms;Alleles;Amino Acid Sequence;Amyotrophic Lateral Sclerosis;Apraxia;Area;Ataxia;Axonal Neuropathy;Biochemical;Biological Models;Biophysics;Buffers;candidate identification;Cell Physiology;Characteristics;chromatin immunoprecipitation;Clinical;clinically significant;Complementary RNA;Complex;computational chemistry;Computer Analysis;computerized tools;Computing Methodologies;curve fitting;Data;Data Analyses;Data Set;Databases;Defect;Detection;Development;Disease;disease-causing mutation;Drug Targeting;Enzyme-Linked Immunosorbent Assay;Eukaryota;exosome;experimental analysis;experimental study;Follow-Up Studies;Funding;Gene Dosage;Genetic;Genetic Diseases;Genetic Heterogeneity;genetic variant;Genetic Variation;Genome;genome sequencing;Goals;helicase;Heterozygote;high throughput screening;Human;Human Genetics;in vivo;Incidence;Individual;insight;interest;Investigation;Label;Lead;Measurement;Measures;Messenger RNA;Methods;Missense Mutation;Modeling;Molecular;molecular pathology;multidisciplinary;mutant;Mutation;Neurodegenerative Disorders;Nucleic acid sequencing;oculomotor;Outcome;Pathology;patient screening;Patients;Penetrance;Peptide Sequence Determination;Phosphorylation;Pontocerebellar hypoplasia;Population;Post-Translational Protein Processing;Process;Protein Complex Subunit;protein expression;protein function;protein profiling;protein protein interaction;Protein Sequence Analysis;Proteins;Proteome;Proteomics;Quality Control;Rare Diseases;rare genetic disorder;Reproducibility;Research;RNA;RNA Degradation;Role;Screening procedure;Signal Transduction;Specificity;Spectrometry;Speed;Spinocerebellar Ataxias;Statistical Data Interpretation;System;Testing;The Cancer Genome Atlas;Therapeutic;tool;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Thermal proteome profiling for analysis of protein sequence variants in human genetic disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative The project is to design, develop and evaluate a novel informatics platform that leverages Semantic Web technologies, FHIR models/profiles, and ontologies for effective standards-based data integration and distributed analytics for enabling high-quality reproducible clinical and translational research. The outcome of the project will advance the automation of FHIR-based clinical data integration and sharing, and accelerating standards-based data discovery and distributed analytics in clinical and translational research. 1

PI_NAMEs: FREIMUTH, ROBERT RICHARD (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acceleration;Automation;Catalogs;Clinical;Clinical Data;clinical data repository;Clinical Research;Collection;Communities;community engagement;computer based Semantic Analysis;Data;data access;data access system;Data Discovery;data integration;data management;data modeling;data repository;data resource;Data Set;data sharing;Data Sources;data standards;Databases;design;Disparate;Electronic Health Record;Extensible Markup Language;Fast Healthcare Interoperability Resources;Foundations;Future;Genetic;Geography;Goals;Health;Healthcare;Human;Informatics;information model;Information Resources;Institution;interoperability;Language;Link;Maps;Modeling;next generation;novel;Ontology;open data;open source;open source tool;Outcome;Publishing;Readability;Reference Standards;Reproducibility;Research;Research Personnel;Resource Description Framework;Resources;Semantics;Shapes;Slice;Source;Specific qualifier value;Standardization;Structure;success;System;Technology;Terminology;tool;Translational Research;Validation;Vendor;Vision;Vocabulary

PROJECT_TITLE: FHIRCat: Enabling the Semantics of FHIR and Terminologies for Clinical and Translational Research

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: NARRATIVE The four serotypes of DENV are significant causes of morbidity and mortality worldwide, as half of the world’s population is at risk of DENV infection. The recently licensed DENV vaccine is not approved for use in people who are younger than 9 years old and are naïve with respect to prior DENV exposure. At present, a DENV vaccine that protects infants and young children, who represent highly vulnerable populations for manifesting severe dengue disease, and naïve individuals of all ages is a global health priority. This project will advance our understanding of the mechanisms regulating protective vs pathological Ab responses to DENV, and in so doing, contribute to the development of safe and effective DENV vaccines.

PI_NAMEs: SHRESTA, SUJAN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 9 year old;Adult women;Affect;Age;Antibodies;Antibody Response;Antibody titer measurement;Antibody-Dependent Enhancement;Antigen-Antibody Complex;Antigens;Automobile Driving;Avidity;Binding;Biological Assay;CD4 Positive T Lymphocytes;Cell Count;Cells;Child;ChIP-seq;Country;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Development;Disease;Dose;Epidemiology;epigenomic profiling;Exhibits;Flavivirus;Flavivirus Infections;Flow Cytometry;Frequencies;Genomics;Geography;global health;Health Priorities;Helper-Inducer T-Lymphocyte;Human;Immune;Immune response;Immune system;Immunity;Immunization;Immunize;Immunoglobulin G;Immunology;Individual;Infant;Infection;insight;Japanese encephalitis virus;Knowledge;Licensing;Maternal antibody;maternal vaccination;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mosquito-borne;Mothers;mouse model;Mus;neutralizing antibody;novel;novel vaccines;offspring;OX40;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Persons;Phylogenetic Analysis;Play;Population;Predisposition;prevent;Production;prospective;Proteins;Publishing;pup;receptor;Regulatory Pathway;Regulatory T-Lymphocyte;Replicon;response;Risk;RNA;Role;Serotyping;severe dengue;System;T cell response;T-Lymphocyte;Testing;transcriptome sequencing;transcriptomic profiling;Tumor Necrosis Factor Receptor;Vaccination;vaccination strategy;vaccine candidate;vaccine platform;vaccine strategy;vaccine-induced antibodies;Vaccines;Viral;Viral Load result;Viral Pathogenesis;Virus;Vulnerable Populations;Work;Zika Virus;ZIKV disease

PROJECT_TITLE: Maternal Antibody-Mediated Enhancement of Dengue Pathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Neuroimmune signaling regulates voluntary alcohol consumption in rodent models and activation of specific pathways results in escalation of drinking. Using single cell, spatial, and multi-omic transcriptome technologies, we are now able to precisely define cell-specific molecular mechanisms that significantly reshape the neuroimmune transcriptome.

PI_NAMEs: MAYFIELD, R. DAYNE (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Agonist;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Anatomy;Animal Model;Animals;Autopsy;behavioral phenotyping;Biological Assay;Brain;brain cell;Candidate Disease Gene;cell type;Cells;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;data integration;Data Set;Development;drinking;drinking behavior;Feedback;Gene Expression;gene network;Genes;Genetic;genome wide association study;genomic locus;Heavy Drinking;Human;Human Genome;human model;Immune;Immune signaling;improved;in vivo evaluation;Individual;Inflammatory;Inflammatory Response;Innate Immune System;Link;Maps;Mediating;member;Molecular;mouse model;Multiomic Data;multiple omics;Mus;Mutation;Neuroglia;Neuroimmune;Pathway interactions;Phenotype;preference;Prefrontal Cortex;problem drinker;Reporter;Resolution;response;Rodent Model;Role;Shapes;Signal Transduction;single nucleus RNA-sequencing;Techniques;Technology;therapeutic target;TLR7 gene;tool;transcriptome;transcriptomic profiling;transcriptomics;Validation;Variant;Viral Vector;Work

PROJECT_TITLE: 2/11 Spatially Resolved, Single Cell, Neuroimmune Transcriptomes in Alcohol Dependence


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: RIVERSIDE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: The lack of an efficient therapeutic strategy against flavivirus virus infection has raised a global health concern. This proposal will lead to an in-depth understanding of the mechanisms by which the NS5 proteins from two members of flavivirus family, Zika virus (ZIKV) and dengue virus (DENV), suppress human STAT2 protein and related host interferon responses. Ultimately, this study will help the development of a novel therapeutic strategy against flavivirus infection.

PI_NAMEs: HAI, RONG  (contact)

PROJECT_TERMS: Affect;antagonist;Anti-viral Agents;Attenuated Vaccines;Binding;Binding Proteins;Biochemical;Cells;Complex;Cryoelectron Microscopy;Data;Dengue Virus;Development;Epidemic;Evaluation;Family;Flavivirus;Flavivirus Infections;Gene Expression;global health;Goals;Host Defense;Human;In Vitro;in vivo;Infection;inhibitor;insight;Integration Host Factors;interferon-stimulated gene factor 3;Interferons;Knowledge;Link;Mediating;member;Molecular;molecular recognition;multicatalytic endopeptidase complex;Mutation;Nonstructural Protein;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathway interactions;Physiological;prevent;Process;prophylactic;protein degradation;Proteins;Public Health;response;RNA;Role;Signal Pathway;Signal Transduction;Species Specificity;Specificity;Stat2 protein;Techniques;Testing;Therapeutic;ubiquitin-protein ligase;Vaccines;vector-borne;Viral;Viral Genes;Viral Pathogenesis;Viral Vaccines;virology;Virus;Virus Diseases;X-Ray Crystallography;Zika Virus

PROJECT_TITLE: Mechanistic Insights into flavivirus NS5-mediated STAT2 Suppression

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Many human diseases including genetic disorders and cancers are caused by mutations in transcription factors or their dysregulation. The overall goal of this project is to determine the mechanism of transcription by eukaryotic RNA polymerase I (Pol I) and how it is dysregulated in disease. This work will provide fundamental knowledge about the basic molecular mechanism of Pol I transcription and discover key steps that may be targeted in cancer and developmental disorders to enhance health and reduce illness.

PI_NAMEs: KNUTSON, BRUCE ALAN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Architecture;Binding Proteins;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biophysics;Cancer Etiology;cell growth;Cell Proliferation;Cells;Complement;Complex;craniofacial disorder;Defect;developmental disease;Diagnosis;Disease;DNA;DNA Polymerase I;DNA Polymerase II;DNA Polymerase III;DNA-Protein Interaction;Down-Regulation;extracellular;Fibrinogen;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genomics;Goals;Health;Histones;Human;human disease;Hybrids;innovation;interdisciplinary approach;Intervention;Knowledge;Laboratory Study;Lead;Link;Location;Malignant Neoplasms;Maps;Methodology;Methods;Modeling;Molecular;Molecular Genetics;Mutation;new therapeutic target;novel;Nutrient availability;Outcome;Outcome Study;Peptide Initiation Factors;Play;Positioning Attribute;posttranscriptional;Process;protein function;Proteins;Proteomics;reconstitution;Regulation;Repression;Research;Ribosomal DNA;Ribosomal RNA;Ribosomes;RNA;RNA Polymerase I;Role;rRNA Precursor;Signal Transduction;Stress;structural biology;Structural Models;Structure;System;TATA Box;TATA-Box Binding Protein;Techniques;Testing;Therapeutic;therapy development;transcription factor;Transcription Process;Transcriptional Activation;Translating;United States National Institutes of Health;Up-Regulation;Work;Yeasts

PROJECT_TITLE: New Paradigms for the molecular basis of RNA polymerase I transcription

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Leishmaniasis, despite being a global health problem that affects more than 1 billion people throughout the world, is an understudied pathogen. Therefore, identifying pathways that regulate immune responses to this disease will unravel potential novel targets for therapy. Our research will elucidate a new signaling pathway engaged by Leishmania major, identify therapeutic targets for treatment of leishmaniasis and potentially, other associated inflammatory disorders.

PI_NAMEs: GURUNG, PRAJWAL  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: adaptive immune response;Adaptor Signaling Protein;Affect;anti-fungal agents;Area;Bacterial Infections;Basic Science;BCL10 gene;Biochemical;Biology;Cell Death;Cells;Clinical;combat;Communicable Diseases;Complex;Cutaneous Leishmaniasis;Cytoplasm;Data;dectin 1;Development;Disease;effective therapy;Etiology;Event;Family;Genetic;global health;Goals;Grant;Homeostasis;Host resistance;Human;Immune;Immune response;Immunity;Infection;Inflammasome;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Knowledge;Leishmania;Leishmania major;Leishmaniasis;Link;Mediating;Metabolic Diseases;Modeling;Molecular;Molecular Target;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Multiple Sclerosis;Mus;Mycoses;new therapeutic target;novel;novel therapeutics;obligate intracellular parasite;Outcome;Parasites;pathogen;Pathogen detection;Pathogenesis;Pathology;Pathway interactions;Persons;Phosphotransferases;Play;Predisposition;Protein Kinase Interaction;Publishing;receptor;Receptor Activation;Receptor-Interacting Protein;Research;Resistance;response;restoration;Role;sensor;Signal Pathway;Signal Transduction;skin disorder;Surface;targeted treatment;therapeutic target;treatment strategy;Virus Diseases;Work

PROJECT_TITLE: Implicating a previously unknown Dectin1-RIPK2-CARD9 signaling in providing resistance against Leishmania major infection

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The contributions of repressive cis-regulatory elements (silencers and enhancer blockers) to regulatory control and the results of their misregulation in cancer have been understudied relative to these elements’ predicted abundance in the human genome, in large part due to the lack of a high-throughput reporter assay designed specifically to address the limitations inherent to identifying them. Previously, enhancer assays have been used for repressive element detection but suffer from high false positive and false negative rates and low replicability, limiting their ability to detect negative regulatory elements (NREs). The goal of this project is to develop a high- throughput reporter assay which overcomes these limitations, allowing efficient and robust identification and characterization of novel NREs and expanding our understanding of the role that NREs play in gene regulation across many cancer cell types.

PI_NAMEs: BOYLE, ALAN P (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Address;Automobile Driving;Biological Assay;Breast Cancer Cell;Cancer Biology;cancer cell;Cancer cell line;carcinogenesis;Cell Line;cell type;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Data;Data Set;design;Detection;detection assay;Development;Disease;Disparity;DNA Sequence Alteration;Elements;Enhancers;ESR1 gene;Estradiol;Estrogen Receptors;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome wide screen;Genomics;Goals;high throughput screening;Human Genome;improved;innovation;Lead;Libraries;Malignant Neoplasms;Maps;MCF7 cell;Methods;Modeling;Morphologic artifacts;Mutation;neoplastic cell;Noise;Normal Cell;novel;Oncogenes;Outcome;Performance;Pharmaceutical Preparations;Pharmacotherapy;Plasmids;Play;programs;promoter;Publishing;Regulatory Element;Reliability of Results;Reporter;Reporter Genes;Repression;Reproducibility;Research;response;Role;Sampling;Signal Transduction;Single Nucleotide Polymorphism;System;Technology;Testing;Time;Transcript;transcription factor;transcriptome sequencing;Transfection;tumor;tumor progression;tumorigenesis;Untranslated RNA;Variant;variant of unknown significance;Work

PROJECT_TITLE: High-throughput inverted reporter assay for characterization of silencers and enhancer blockers


NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Adverse morbidity Streptococcus inflammation  pregnancy outcomes, including premature birth and stillbirth, are the leading causes of neonatal and mortality. A frequent cause is Intrauterine infection, which occurs when bacteria like Group B (GBS) ascend from the vagina into the uterus and invade the amniotic cavity, leading to and tissue damage. As maternal GBS colonization of the female genital tract (FGT) represents the major risk factor for adverse pregnancy outcomes my research seeks to elucidate the molecular mechanisms that govern the dynamic aspects of GBS vaginal carriage and ascension to the FGT.

PI_NAMEs: DORAN, KELLY S (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute suppurative arthritis due to bacteria;Address;Adherence;Adult;adverse pregnancy outcome;amniotic cavity;antagonist;anti-toxin;Antigens;aspirate;Bacteria;Bacterial Adhesins;Bioinformatics;Birth;Cell Communication;Cells;commensal microbes;Complex;Contracts;Development;Diabetes Mellitus;Disease;Elderly;epithelial to mesenchymal transition;Epithelium;female reproductive tract;Fetus;Gastrointestinal tract structure;Group B Streptococcus colonization;HIV;Host Defense;host microbiota;IL17 gene;Immune;immune activation;Immune response;Immunity;immunodeficiency;In Vitro;in vivo Model;Infant;Infection;Inflammation;Integration Host Factors;Intermediate Filaments;intrauterine infection;Invaded;Keratin-19;Malignant Neoplasms;Mediating;Meningitis;Microbe;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Neonatal;neonatal infection;neonate;normal microbiota;Osteomyelitis;pathobiont;Pathogenesis;placental infection;placental membrane;Play;Pneumonia;Population;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Process;Production;Reporter;reproductive tract;Research;response;Risk Factors;Role;Sepsis;Signal Transduction;stillbirth;Streptococcal Infections;Streptococcus;Streptococcus Group B;Surface;System;T-Lymphocyte;Tertiary Protein Structure;Tissues;Toxin;Uterus;Vagina;vaginal fluid;vaginal microbiota;Vimentin;Woman

PROJECT_TITLE: Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tract

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a devastating lung disease of older veterans marked by progressive respiratory failure for which there remains a significant unmet need for effective medical therapies. Lung epithelial cell dysfunction has emerged as an important causal contributor to the development of fibrotic lung scarring. In order to improve our understanding of IPF, we generated two novel mouse models expressing IPF-associated mutations in the lung epithelial cell restricted Surfactant Protein C gene (SFTPC). Using this preclinical platform we will characterize the mechanisms underlying lung epithelial dysfunction found in SFTPC mice including abnormal cellular quality control responses (e.g. endoplasmic reticulum stress, autophagy, mitophagy) and metabolic reprogramming. Results funded by this project will permit rapid identification of new cell populations, signaling pathways, and molecular targets thus accelerating the discovery of new IPF treatments.

PI_NAMEs: BEERS, MICHAEL FRANCIS (contact)

PROJECT_TERMS: Acceleration;Address;Adult;aerobic glycolysis;Affect;Aging;Alleles;Alveolar;alveolar epithelium;Anabolism;Apoptosis;Architecture;arm;Autophagocytosis;Bioenergetics;biological adaptation to stress;Biological Markers;cell behavior;Cells;Cellular biology;Cellular Stress;Cessation of life;Characteristics;Chronic;Cicatrix;Classification;Clinical;Communities;Consensus;Coupled;Data;design;Development;Disease;Distal;Elements;endophenotype;endoplasmic reticulum stress;Epithelial Cells;epithelial injury;Epithelium;Event;Evolution;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;fibrotic lung disease;Foundations;Functional disorder;Funding;Gases;Gene Mutation;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Glycolysis Pathway;Hand;Histology;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;Inflammatory;inhibition of autophagy;Injury;injury and repair;Interstitial Lung Diseases;Journals;Knock-in;Knock-in Mouse;Link;Lung;Lung Diseases;Maps;Mediating;Medical;Metabolic;Metabolic Control;Metabolic Pathway;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutant Strains Mice;Mutation;nintedanib;non-Native;novel;older adult;Organelles;Organoids;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Peripheral;pharmacologic;Phenotype;Physiological;Physiology;Pirfenidone;Play;Policies;Population;pre-clinical;Pre-Clinical Model;Process;Program Reviews;programs;Proliferating;Protein Isoforms;Published Comment;Publishing;Pulmonary Fibrosis;Pulmonary Surfactant-Associated Protein C;Quality Control;Reagent;Refractory;repaired;Reporting;Respiratory Failure;response;Role;Secondary to;segregation;Signal Pathway;single-cell RNA sequencing;stem cell function;stem cells;Stress;Testing;Therapeutic;therapy outcome;Time;tool;trafficking;Translating;Transplantation;Usual Interstitial Pneumonia;Veterans;Work;wound healing

PROJECT_TITLE: Surfactant Protein C Mutations and Interstitial Lung Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In a series of genetic studies, we have identified and validated SVEP1 as a novel extracellular matrix protein that promotes atherosclerosis in humans and mice. The mechanisms underlying the role of SVEP1 in the pathophysiology of atherosclerotic disease, however, remain unknown. In this proposal we will assess the cellular and molecular impact of SVEP1 in the development of atherosclerosis and determine which of its protein interactions are required for its effects, thereby expanding our understanding of how this protein influences disease and evaluating the therapeutic potential of targeting SVEP1 as a treatment for coronary artery disease.

PI_NAMEs: STITZIEL, NATHAN OLIVER (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Address;Affect;Affinity;Alleles;Arterial Fatty Streak;Atherosclerosis;behavior influence;Binding;Biological Assay;Cardiovascular Diseases;cardiovascular disorder risk;causal variant;cell behavior;Cell Differentiation process;cell growth;Cell Lineage;Cell Proliferation;Cells;Characteristics;Coronary Arteriosclerosis;Data;Development;Disease;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Functional disorder;Genes;genetic association;Genetic Polymorphism;Genetic study;Genetic Transcription;genome wide association study;genome-wide;Goals;Health;Heterozygote;Human;human disease;Human Genetics;In Vitro;in vivo;insight;integrin alpha9 beta1;Integrins;Knockout Mice;Label;LDL Cholesterol Lipoproteins;Lipids;LoxP-flanked allele;Mediating;Mendelian randomization;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;new therapeutic target;notch protein;NOTCH3 gene;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Pathway interactions;Phenotype;Plasma;Proliferating;Protein Deficiency;Protein Region;Proteins;Reagent;receptor;Residual state;Risk;risk variant;Role;Series;Signal Transduction;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;stem;Surface Plasmon Resonance;Testing;Therapeutic;therapeutic target;Variant;Vascular Smooth Muscle;vascular smooth muscle cell proliferation

PROJECT_TITLE: Mechanistic Studies of the Novel Human Coronary Artery Disease Gene SVEP1

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Estrogen;Nutrition;Obesity;Prevention;Sleep Research;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Postmenopausal women, who have very low levels of circulating estrogens, are at high risk of life-threatening, obesity-related disorders such as metabolic syndrome. Many studies have shown that estrogen is the factor that protects women from metabolic risk. This project will investigate new directions in estrogen and circadian biology research in mouse models and therapeutic feeding behaviors for at-risk postmenopausal women.

PI_NAMEs: PENDERGAST, JULIE S (contact)

PROJECT_TERMS: actigraphy;Age;Agonist;arm;Behavior;Biological;Body Weight;Body Weight Changes;cancer risk;Cardiometabolic Disease;cardiometabolism;Cessation of life;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Clinical Trials Design;comorbidity;Complex;Control Groups;Cost of Illness;Cues;Darkness;Data;Diabetes Mellitus;diet-induced obesity;Disease;Eating;Eating Behavior;ESR1 gene;Estradiol;Estrogen decline;Estrogen deficiency;Estrogen Receptor 2;Estrogen Receptors;Estrogen Therapy;Estrogens;estrophilin;Excision;experimental study;Exposure to;Fasting;Fatty acid glycerol esters;feeding;Feeding behaviors;Female;Food;Functional disorder;Glucose Intolerance;GTP-Binding Proteins;Health;heart disease risk;Heart Diseases;Hepatocyte;High Fat Diet;high risk;Hour;improved;Incidence;Insulin Resistance;insulin sensitivity;Intervention;Knockout Mice;Life;Light;Liver;male;Malignant Neoplasms;Measures;men;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Molecular;molecular clock;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;Outcome;Ovariectomy;Overweight;Pattern;Phase;Physiology;Postmenopause;Pre-Clinical Model;Prediabetes syndrome;Predisposition;Premenopause;primary outcome;protective factors;Randomized;Randomized Controlled Clinical Trials;receptor expression;Research;Resistance;Rest;Risk;Risk Factors;Risk Reduction;Role;Sex Differences;Signal Transduction;Stroke;System;Testing;Text;Therapeutic;therapeutic target;time use;Time-restricted feeding;Tissues;United States;Woman

PROJECT_TITLE: Circadian Regulation of Metabolic Risk in Mice and Women: Role of Estrogen and Time-Restricted Feeding

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Wound Healing and Care

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Dermis is a complex connective tissue that provides protective, regulatory, and sensory support to the epidermis. This project will significantly advance our understanding of the pathological and physiological roles of the PDGFRβ signaling in the dermis. This information will be significant to human health because it will open the way to precisely modulate PDGF signaling as a treatment strategy for skin disease and regenerative medicine.

PI_NAMEs: OLSON, LORIN E (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adipose tissue;Adult;age acceleration;Aging;AKT1 gene;Animal Genetics;Animal Model;Animals;Atrophic;cell age;Cell Aging;Cell Cycle;Cell Physiology;cell type;Cells;Characteristics;Cicatrix;combinatorial;Complex;Connective Tissue;Data;Dermal;Dermis;Disease;disease phenotype;Diving;Epidermis;Equilibrium;Exhibits;experimental study;Family member;Fibroblasts;Fibrosis;gain of function;gain of function mutation;Gene Deletion;gene function;Genes;Genetic;genetic approach;Genetic Epistasis;Genetic Models;genome sequencing;Genotype;Growth;Hair;Health;Human;human disease;IGF1 gene;In Vitro;in vivo;inducible Cre;inhibitor;Insulin-Like Growth Factor I;interest;Keloid;Lesion;Lipoatrophy;Maintenance;Mediating;Mediator;Molecular;Morphogenesis;mouse genetics;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel therapeutic intervention;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;PDGFA gene;PDGFRB gene;Pericytes;permissiveness;Phenotype;Phosphorylation;Physiological;Physiology;platelet function;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Proto-Oncogene Proteins c-akt;Publications;pup;rare genetic disorder;Regenerative Medicine;Role;Sensory;Signal Pathway;Signal Transduction;Skin;skin disorder;skin fibrosis;Skin Physiology;Smooth Muscle Myocytes;STAT1 gene;STAT1 protein;Stat5 protein;Syndrome;Testing;Tissues;transcription factor;treatment strategy;Vascular Smooth Muscle

PROJECT_TITLE: PDGFRB Signaling in Progressive Skin Disease

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Successful completion of the proposed aims will provide a systematic, experimentally validated understanding of how laryngeal and vocal tract adjustments affect voice production and vocal fold contact pressure, and a better understanding of the scientific rationale for voice therapy in treating patients with phonotraumatic vocal hyperfunction. In the long term, the identification of potential objective predictors of voice therapy outcomes will allow clinicians to better monitor and target patient-specific vocal behavior to improve treatment outcomes in voice therapy.

PI_NAMEs: ZHANG, ZHAOYAN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Anterior;Behavior;Data;Effectiveness;Esthesia;Exercise;experimental study;Goals;Human;human subject;improved;in vivo;Injury;Larynx;Lesion;Literature;Measures;Medial;Methods;Modeling;Monitor;Oral cavity;Outcome Measure;Output;Patient Outcomes Assessments;Patients;Pattern;Pharyngeal structure;Phonation;pressure;Production;Reporting;Research;Scanning;secondary outcome;simulation;sound;Surface;Techniques;therapy outcome;Thick;Treatment outcome;vocal cord;Voice;voice therapy;Voice Training;X-Ray Computed Tomography

PROJECT_TITLE: Laryngeal and vocal tract strategies to reduce vocal fold contact pressure

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Brain Disorders;Contraception/Reproduction;Epilepsy;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Patients with temporal lobe epilepsy exhibit increased rates of reproductive endocrine dysfunction. The research outlined in this proposal will identify points of epilepsy-associated dysfunction in the neural circuits controlling reproductive function. This knowledge will provide a foundation from which others can build when developing therapeutic strategies.

PI_NAMEs: INGRAM, ROBBIE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Adult;adverse outcome;Amenorrhea;Animal Model;Beds;Benchmarking;Brain;brain control;Bypass;Calcium;career;Cell Nucleus;Cells;Clinical Research;Closure by clamp;comorbidity;Data;Development;Diagnosis;Diestrus;Electric Stimulation;Electrophysiology (science);Endocrine;Endocrine System Diseases;Environment;Epilepsy;Estrous Cycle;Estrus;Exhibits;experience;extracellular;Female;Foundations;Functional disorder;gamma-Aminobutyric Acid;General Population;GNRH1 gene;Goals;Gonadotropin Hormone Releasing Hormone;Hippocampus;Hypothalamic structure;Image;In Vitro;insight;Kainic Acid;KISS1 gene;Knowledge;Laboratories;Laboratory Research;Learning;Link;Luteinizing Hormone;male;median eminence;Mediator;men;mouse model;Mus;National Institute of Neurological Disorders and Stroke;neural circuit;neuromechanism;neuronal circuitry;neuronal excitability;Neurons;novel therapeutic intervention;Output;Partial Epilepsies;patch clamp;Patients;Pattern;Periodicity;Pituitary Gland;Play;Polycystic Ovary Syndrome;Population;postsynaptic;Presynaptic Terminals;prevent;Reproduction;reproductive;reproductive function;reproductive system disorder;Research;Research Personnel;response;Seizures;Seminal fluid;sex;sex cycle;Slice;Source;Structure of nucleus infundibularis hypothalami;Synapses;Synaptic Transmission;Temporal Lobe Epilepsy;Testing;Testosterone;Therapeutic;Training;translational impact;transmission process;two-photon;Ventricular;Woman

PROJECT_TITLE: Epilepsy-Associated Dysfunction in the Kisspeptin-GnRH Neural Circuit


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative  In the last several years, a number of genes for familial lipodystrophies have been discovered but the molecular basis of many patients remains unknown. Thus, the first aim of this proposal is to identify additional lipodystrophy gene(s)/variant(s). The second aim is to study relationship of the molecular defects with clinical characteristics and metabolic derangements in patients with lipodystrophies.

PI_NAMEs: GARG, ABHIMANYU  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Acanthosis Nigricans;adipocyte biology;adipocyte differentiation;Adipose tissue;ADRA2A gene;Affect;AKT2 gene;autoinflammatory;Biochemical;Biological;Biological Models;Biological Process;Body fat;Body Regions;BSCL2 gene;causal variant;CAV1 gene;Cell Line;Cell model;Cessation of life;Characteristics;Clinical;clinical phenotype;deafness;Defect;design;Development;Diabetes Mellitus;Disease;disease-causing mutation;Dual-Energy X-Ray Absorptiometry;Dyslipidemias;Dysplasia;early onset;Etiology;Familial generalized lipodystrophy;Familial partial lipodystrophy;Family;Family member;Fatty Liver;FBN1;Fibroblasts;gene function;Genes;Genetic;genetic approach;genetic pedigree;genome sequencing;genomic locus;Genomics;Genotype;Goals;Grant;Health;Hernia;Heterozygote;HIV-Associated Lipodystrophy Syndrome;Hypertriglyceridemia;in vitro Assay;insight;Insulin Resistance;Knowledge;Laboratories;Lipodystrophy;lymphoblast;Magnetic Resonance Imaging;Mandible;Measurement;Mendelian disorder;Mental Depression;Metabolic;metabolic abnormality assessment;Molecular;Molecular Genetics;Morbidity - disease rate;Mutation;new therapeutic target;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;NOTCH3 gene;novel;novel therapeutics;Obesity;Pathway interactions;Patients;Phenotype;Polymerase Chain Reaction;PPARG gene;proband;Process;recruit;Rieger syndrome;Role;SHORT syndrome;Skin;Skinfold Thickness;Syndrome;Technology;Teething;Therapeutic Intervention;Tissues;transcriptome;transcriptome sequencing;United States;Variant;whole genome;Wiedemann-Rautenstrauch syndrome;Work

PROJECT_TITLE: Genetic and Metabolic Basis of Familial Lipodystrophies

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Influenza;Networking and Information Technology R&D (NITRD);Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The proposed study is relevant to profound disparities in COVID-19 and other health conditions and lower coverage for all recommended adult vaccinations, including the COVID-19 vaccine among Latinos communities. This proposal will test the efficacy of a combination intervention REDES (“Networks”) - a social network and mobile health (mHealth) enhanced community health worker (CHW) intervention - to address COVID-19 vaccine hesitancy and uptake among a cohort of Latinos and their networks in Maryland. The proposed study will be the first to rigorously test a peer network and mHealth vaccine intervention integrated into state-of-the-art CHW-led community care for Latinos.

PI_NAMEs: PAGE, KATHLEEN R (contact);YANG, CUI

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adult;Appointments and Schedules;Attention;Authorization documentation;behavior change;Behavioral;bilingualism;Clinic;cohort;Communities;community building;community engagement;Community Health;Community Health Aides;Community Healthcare;community partners;Consolidated Framework for Implementation Research;Control Groups;COVID-19;COVID-19 booster;COVID-19 burden;COVID-19 disparity;COVID-19 pandemic;COVID-19 testing;COVID-19 vaccination;COVID-19 vaccine;digital;Disparity;disparity reduction;Dizziness;Dose;effective intervention;efficacy evaluation;efficacy testing;Enrollment;Equity;Evaluation;experimental group;Family;flexibility;Friends;Funding;Future;Health;health literacy;Hospitalization;Hotlines;Immigrant;Immigration;implementation determinants;implementation evaluation;implementation outcomes;implementation science;implementation strategy;indexing;Individual;Influenza vaccination;Infrastructure;Intake;Interdisciplinary Study;interest;Intervention;Interview;Knowledge;Language;Latino;Latino Population;Life;Limited English Proficiency;Low income;marginalization;Maryland;member;Methodology;mHealth;mhealth interventions;Modeling;Motivation;Not Hispanic or Latino;outreach;Participant;peer;peer coaching;peer networks;Persons;Policies;prospective;Public Opinion;RADx Underserved Populations;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;recruit;Reduce health disparities;reinforced behavior;Reporting;Resources;Respondent;response;Sampling;seasonal influenza;skills;Social Network;Spanish/English;Structure;success;Surveys;Testing;Text Messaging;theories;tool;Touch sensation;Training;Trust;United States National Institutes of Health;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine hesitancy;Vaccines

PROJECT_TITLE: REDES: a peer network and mobile health (mHealth) enhanced CHW model to maximize COVID-19 vaccination among low income Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(90)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Substance Misuse Prevention;Suicide;Suicide Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Disparities in substance use and high rates of suicide pose significant risk to American Indian youth. Strategies for early prevention are needed, but evidence on what is effective for this population is lacking. This study will test the effectiveness of a substance use prevention program tailored for American Indian youth and families that also holds promise for impacting suicide risk, providing an opportunity for efficient intervention in communities with limited resources.

PI_NAMEs: WHITESELL, NANCY RUMBAUGH (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;Adolescent;adolescent substance use;Adoption;Adult;Alaska Native;American Indian community;American Indian Population;American Indians;Attention;Child;Colorado;Communication;Communities;community engagement process;community partners;Country;design;directed attention;Discipline;Disparate;Disparity;early onset substance use;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness trial;Ethnic Population;Evaluation;evidence base;Family;Feeling suicidal;Health;Heroin;Home;improved;Intervention;Link;Measures;member;Mental Health;Motivation;multiphase optimization strategy;Northern Plains;opioid epidemic;opioid use;Outcome;Oxycodone;parental monitoring;parenting intervention;Parents;Pattern;peer;Personal Satisfaction;Population;prevent;Prevention;Prevention program;Prevention strategy;Process;Program Appropriateness;programs;protective factors;Public Health Schools;racial population;randomized controlled design;reduced substance use;reducing suicide;Reporting;Research;Research Personnel;Resource Allocation;Resources;response;Risk;Risk Behaviors;Risk Factors;Science;skills;substance use;Substance Use Disorder;substance use prevention;substance use treatment;suicidal risk;Suicide;Suicide attempt;suicide rate;System;Testing;therapy development;tool;trend;tribal community;United States;Universities;Work;Youth

PROJECT_TITLE: Evaluation of an optimized intervention to prevent early substance use among American Indian youth: Examination of expanded impacts on youth and parents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(51)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative While DNA mutations have been sequenced in many different tumor types, the mutational profile of pancreatic neuroendocrine tumors is unique, with frequent alterations in DAXX and ATRX. As we currently do not yet understand how these mutations lead to disease, we will use physiologically relevant models (both mouse and human) to understand the normal functions of these genes and then evaluate what happens when they are lost or mutated. Combined these studies will advance our understanding how pancreatic neuroendocrine tumors develop, thereby providing the foundations for the development of new therapeutic approaches to treat these cancers.

PI_NAMEs: WASYLISHEN, AMANDA RIETTA (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affect;Alleles;Apoptosis;ATRX gene;Biochemical;Biological;cancer heterogeneity;career;career development;Career Transition Award;cell growth regulation;Cells;Centromere;Chromatin;Complement;Complex;Data;DAXX gene;Deposition;derepression;Development;Disease;DNA;DNA Methylation;DNA Sequence Alteration;DNA Transposable Elements;Elements;Embryo;Endocrine;Endoderm;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenome;epigenomics;Exhibits;Experimental Genetics;Foundations;Frequencies;Functional disorder;Funding;Gene Expression Profile;gene function;Genes;Genetic;Genetic Models;Genetic Transcription;genome sequencing;genome-wide;genomic profiling;Genomics;Goals;Heterochromatin;histone methylation;Histones;Homeostasis;Human;human disease;human model;human pluripotent stem cell;Impairment;in vivo;in vivo regeneration;Inflammation;innovation;Institution;Islet Cell Tumor;Islets of Langerhans;Knockout Mice;Laboratories;Lead;Lesion;Link;Long Terminal Repeats;loss of function mutation;Malignant Neoplasms;Manuscripts;Mediating;Modeling;Molecular;Molecular Chaperones;Mouse Embryonic Stem Cells;mouse genome;mouse model;Mus;Mutate;Mutation;Neurosecretory Systems;Normal tissue morphology;novel;novel therapeutic intervention;Other Genetics;Pancreas;Pancreatitis;permissiveness;Physiological;Precision therapeutics;Productivity;programs;promoter;Recovery;Recurrence;Regenerative response;Regulation;Reporting;Research;research and development;Role;Somatic Cell;stem cell model;Stress;telomere;Telomere Pathway;Tissues;Transcriptional Silencer Elements;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Variant

PROJECT_TITLE: The DAXX/ATRX/H3.3 axis in ERV regulation and tumor suppression


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Infectious Diseases;Opioid Misuse and Addiction;Opioids;Sexually Transmitted Infections;Substance Misuse

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: Project Narrative  Opioid use disorders (OUD) are a continuing public health emergency. Public sexually transmitted disease (STD) clinics are high-volume medical settings that serve a high-risk patient population, with high prevalence of untreated OUD.  This study will examine the effectiveness of OUD treatment linkage strategies for opioid-dependent patients seeking care at walk-in STD clinics, comparing Usual Care (UC), referral via Patient Navigation (PN), and Patient Navigation + Buprenorphine Initiation (PN+BUP) in a parallel 3-arm randomized clinical trial. The study could have high impact, spurring novel integration of OUD treatment linkage services within the STD care sector.

PI_NAMEs: GRYCZYNSKI, JAN  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Accident and Emergency department;Adherence;Admission activity;Antibiotics;Appointment;arm;authority;Behavior;Biological Markers;Buprenorphine;buprenorphine treatment;care seeking;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Clinic Visits;Communities;cost;Coupled;Data;Drug usage;effective therapy;effectiveness evaluation;Epidemic;Event;experience;Exposure to;Fentanyl;follow-up;Funding;Health;health record;Health Services;Heroin;High Prevalence;high risk;high risk population;HIV;HIV Infections;Hospitals;Hotlines;illicit opioid;Individual;innovation;Intake;Interview;Jail;Lead;Link;Medical;meetings;Methods;Morbidity - disease rate;mortality;Naloxone;National Institute of Drug Abuse;novel;novel strategies;Nurse Practitioners;Opiate Addiction;Opioid Analgesics;opioid epidemic;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;overdose death;overdose prevention;Participant;patient navigation;patient navigator;patient population;Patients;Pharmaceutical Preparations;Physician Assistants;Physicians;Population;prescription opioid;Primary Care;primary outcome;Provider;Public Health;public health emergency;randomized, clinical trials;Recommendation;Regimen;Reporting;Research;Research Design;Resources;Risk;Risk Behaviors;Services;Sexually Transmitted Diseases;Statutes and Laws;Structure;Substance Use Disorder;Testing;Time;treatment as usual;treatment program;trial comparing;United States;usual care arm;waiver;Walking;Writing

PROJECT_TITLE: Opioid Use Disorder Treatment Linkage at STD Clinics using Buprenorphine (OUTLAST-B)

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


PHR: PROJECT NARRATIVE Ceramides are fat metabolites that accumulate in individuals susceptible to diabetes and heart disease. Herein we will investigate how a molecular downstream effector of ceramides, Fgf13, mediate its effect in the progression of disease pathology in adipocytes. The work could uncover new therapeutic approaches for metabolic diseases such as diabetes, cardiovascular and heart diseases associated with obesity.

PI_NAMEs: CHAURASIA, BHAGIRATH  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Adrenergic beta-Agonists;Affect;Agonist;Anabolism;Atherosclerosis;Beds;Biological Assay;Biology;Brown Fat;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cells;Ceramides;Clinic;Coupled;Data;Deposition;Development;Diabetes Mellitus;Diet;dihydroceramide desaturase;Disease Progression;Dyslipidemias;Energy Metabolism;Enzymes;Event;Fatty acid glycerol esters;Fatty Liver;feeding;Fibroblast Growth Factor;fibroblast growth factor 13;gain of function;Genes;glucose tolerance;Heart Diseases;Heart failure;Human;Hypertriglyceridemia;Immunoprecipitation;Impairment;improved;In Vitro;in vivo;Individual;inhibitor;Insulin Resistance;insulin sensitivity;knock-down;Knock-out;Link;Lipids;Locales;loss of function;Malignant Neoplasms;Maps;Marketing;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;metabolic rate;Metabolism;Mitochondria;Molecular;Molecular Target;Morphology;mRNA Expression;Mus;Myocardial Infarction;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Obesity;obesity development;Organism;Pathology;Pathway interactions;Predisposition;prevent;Production;prognostic;programs;protein function;Protein Isoforms;Proteins;Regulation;Resistance;Role;Science;Series;serine palmitoyltransferase;Serum;Signal Transduction;Sphingolipids;Stimulus;Stroke;subcutaneous;Testing;Thermogenesis;thermozymocidin;Tissues;Transcript;transcriptomics;Work

PROJECT_TITLE: Role of Ceramide Regulated Fgf13 in AdiposeT issue Biology

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Development of targeted therapies and immunotherapies has revolutionized the treatment of lung cancer. However, recurrence is a major problem and a novel strategy is required for lung cancer treatment. Our major goal in this proposal is to uncover oncogenic roles of KAT5 on lung tumorigenesis to find new therapeutic targets for lung cancer.

PI_NAMEs: KOBAYASHI, SUSUMU  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acetylation;Acetylesterase;Acetyltransferase;Address;beta catenin;Binding;Biochemical;Cancer Etiology;cancer therapy;Candidate Disease Gene;Catalytic Domain;Cell model;Cells;chemotherapy;ChIP-seq;Clinic;Clonal Evolution;Data;Development;Diagnosis;driver mutation;EGFR gene;Epidermal Growth Factor Receptor;Epigenetic Process;epigenetic therapy;experimental study;Future;Gene Silencing;Genes;Goals;Histone Acetylation;histone modification;HTATIP gene;Human;Immunotherapy;In Vitro;in vivo;Individual;inhibitor;knock-down;Knock-out;Knockout Mice;Lung;lung cancer cell;lung development;Lung Neoplasms;lung tumorigenesis;Lysine;Maintenance;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Memory;Modification;mortality;mouse model;Mus;mutant;Mutation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;Pathway interactions;Patient Care;Patients;Phosphorylation;Phosphotransferases;Play;Prognosis;Progressive Disease;Proliferating;Protein Tyrosine Kinase;receptor binding;Receptor Protein-Tyrosine Kinases;Recurrence;Reporting;Resistance;Role;Sampling;self-renewal;Signal Pathway;Signal Transduction;stem;targeted treatment;Testing;Time;Transcription Elongation;Transcriptional Activation;transcriptome sequencing;Transgenic Mice;tumor;tumor growth;tumor heterogeneity;tumor initiation;tumorigenesis;Tyrosine;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;United States

PROJECT_TITLE: Role of KAT5 in lung cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: This research will define how the basic module for information transfer in the brain – the synaptic active zone – forms and matures during development. Given that maturation and plasticity of synapses is a fundamental feature of neuronal signaling and circuit remodeling, it is critical to define molecular mechanisms that control this process. Identification of pathways mediating active zone development and maturation will allow analysis of their role in presynaptic plasticity, as well as how disruptions in these components contribute to brain diseases.

PI_NAMEs: LITTLETON, J. TROY (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: active control;Adult;Affect;Binding Proteins;Brain;Brain Diseases;Categories;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communication;cytomatrix;Development;Drosophila genus;Electrons;Electrophysiology (science);Evolution;falls;Genetic;Glutamates;Growth;Individual;insight;intravital imaging;Invertebrates;Label;Life Cycle Stages;Measures;Mediating;Membrane;Modeling;Molecular;Morphology;Motor Neurons;Muscle;Neuromuscular Junction;neuronal circuitry;Neurons;neurotransmission;neurotransmitter release;optical imaging;Output;patch sequencing;Pathway interactions;Phase;Physiologic pulse;postsynaptic;presynaptic;Presynaptic Terminals;Probability;Process;Production;Property;protein degradation;Proteins;Regulation;Research;RNA;Role;scaffold;Set protein;Signal Transduction;Site;Structural Protein;Structure;superresolution microscopy;Synapses;Synaptic plasticity;Synaptic Receptors;Synaptic Vesicles;tool;trafficking;Variant;Vertebrates;vesicular release;voltage

PROJECT_TITLE: Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research is relevant to the part of NIH’s mission that pertains to improving human health by identifying the mechanisms responsible for fungal infections of the central nervous system so that novel therapeutics can be developed to prevent brain infections.

PI_NAMEs: GELLI, ANGIE  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;aerosolized;Area;Aspergillus;Autopsy;Binding;Blood;blood-brain barrier crossing;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Candida albicans;Cause of Death;CD44 gene;cell motility;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Fungal Infections;Central Nervous System Infections;Cerebral endothelium;Cessation of life;Chronic;Coccidioides;Columbidae;Complex;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Cystic Lesion;Cytoskeleton;Data;design;Development;Disease;Drops;Elements;Endocytosis;Environment;EphA2 Receptor;experimental study;Fungal Spores;fungus;Goals;Health;Histoplasma capsulatum;Hospitalization;Human;improved;In Vitro;in vivo;Infection;Inhalation;innovation;Invaded;Knock-out;Knowledge;Label;Mediating;Meningoencephalitis;migration;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Movement;Mucor;Nature;neurotropic;novel strategies;novel therapeutics;pathogen;Pathogenesis;pathogenic fungus;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;prevent;Process;Proliferating;prophylactic;Publishing;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Reproduction spores;Research;response;Risk;Role;Route;Series;Signal Transduction;Soil;spatiotemporal;spheroids;Structure of parenchyma of lung;Technology;Testing;Time;trafficking;Transactivation;Trees;United States National Institutes of Health;Work

PROJECT_TITLE: The molecular basis for the translocation of fungi from blood-to-brain.

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative/Public Health Relevance Statement Proper neural connections are essential for normal nervous system function. Abnormalities in neural connectivity are associated with a multitude of neurodevelopmental and mental health disorders, including autism and schizophrenia. Determining the mechanisms by which cytoskeletal elements inside the growth cone are coordinated to drive the morphological responses of the growth cone (advance, retraction, and turning) may eventually lead to understanding the basis of neuropsychiatric disorders and may contribute to designing prevention and/or treatment strategies in the future.

PI_NAMEs: LOWERY, LAURA ANNE (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Area;autism spectrum disorder;Award;Axon;axon guidance;Behavior;Binding;Biochemical;Biological Assay;Brain;Cells;confocal imaging;Coupling;Cues;Cytoskeleton;Data;design;Development;Disease;Elements;experience;experimental study;extracellular;F-Actin;Future;Growth Cones;In Vitro;in vivo;insight;Letters;Lighting;Link;Mass Spectrum Analysis;Mediating;Mental disorders;microscopic imaging;Microscopy;Microtubule Polymerization;Microtubules;Modeling;Molecular;Morphology;Motility;mutant;Nervous System Physiology;neural;neurodevelopment;neuronal growth;Neurons;neuropsychiatric disorder;novel;Phosphorylation;Phosphotransferases;Play;Polymerase;Positioning Attribute;Prevention strategy;Proteins;public health relevance;Publishing;quantitative imaging;reconstitution;Regulation;response;Role;Schizophrenia;Sedimentation process;Series;Signal Pathway;Signal Transduction;Structure;Techniques;Testing;Time;tool;Total Internal Reflection Fluorescent;treatment strategy;Work;Xenopus laevis

PROJECT_TITLE: Elucidating mechanistic connections between guidance signaling, microtubule regulation, and growth cone steering


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Early detection of Alzheimer’s dementia is critical to obtaining treatment, counseling, and planning for the future. Bilingualism is known to impact the interpretation of cognitive tests, and very few neuropsychological tests are available for assessment of older deaf adults who regularly use both American Sign Language and English. This project will fill this critical need, by developing tests in ASL and written English, identifying how ASL-English bilingualism affects performance on these tests, and the cognitive profile of deaf AD.

PI_NAMEs: GOLLAN, TAMAR  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;aging related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;American Sign Language;Assessment tool;Behavioral;bilingualism;Cognition;Cognitive;Cognitive deficits;cognitive reserve;cognitive testing;cohort;Communication;Communities;comparison group;Compensation;Complex;Counseling;Data;deaf;deafness;dementia risk;deprivation;Diagnosis;diagnostic accuracy;Disabling;Disparity population;Early Diagnosis;early experience;English Language;Exclusion;executive function;Exhibits;Exposure to;Future;Goals;health disparity;Health Status;Hearing;hearing impairment;human old age (65+);Impaired cognition;Impairment;improved;Individual;Knowledge;Language;Language Disorders;Language Tests;late life;lens;Life;Linguistics;Literature;Measures;Memory;Memory Loss;Methods;Mission;Names;National Institute on Deafness and Other Communication Disorders;Neuropsychological Tests;non-verbal;normal hearing;older adult;Parents;Patients;Pattern;Performance;performance tests;Persons;Population;Population Heterogeneity;Poverty;Prevalence;prevent;Proactive Inhibition;Probability;Procedures;Production;recruit;Research;response;Sampling;Schools;Semantics;Sign Language;Speech;Testing;verbal;Vocabulary;Work;Writing

PROJECT_TITLE: Assessment of Language and Cognition in Older Deaf Signers


NIH_SPENDING_CATS: Cancer;Chronic Pain;Hematology;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

PHR: Project Narrative: Peripheral neuropathy is the main dose limiting side effect of many widely used and effective chemotherapeutic drugs. Most chemotherapy-induced peripheral neuropathies are characterized by loss of nerve fibers (axons). Here we will explore several avenues to block this destructive process. If successful, this project will identify novel treatment strategies for the prevention and treatment of chemotherapy-induced peripheral neuropathy, which have the potential to be translated to the clinic.

PI_NAMEs: GEISLER, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;Aftercare;analog;appropriate dose;Axon;axonal degeneration;Behavioral;Bortezomib;Cancer Model;Cancer Patient;Cancer Survivor;cancer therapy;chemotherapeutic agent;chemotherapy;chemotherapy induced neuropathy;Chemotherapy-induced peripheral neuropathy;Cisplatin;Clinic;Clinical;cofactor;cost;Cultured Cells;Dependovirus;Development;Disease;Dominant-Negative Mutation;Dose;Dose Limiting;Drops;effective therapy;effectiveness testing;emerging virus;Enzymes;Etiology;evidence base;experimental study;functional outcomes;gene therapy;Health;heart metabolism;Hematologic Neoplasms;Hyperalgesia;improved;In Vitro;in vivo;Injections;Intervention;Knock-out;Lead;leukemia;Life;Lifelong disability;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;mouse model;multidisciplinary;Multiple Myeloma;Mus;Nerve;Nerve Fibers;Neurodegenerative Disorders;neuroinflammation;Neurology;neuronal cell body;Neurons;Neuropathy;neurotransmission;Niacinamide;nicotinamide-beta-riboside;novel;Oncology;oral supplementation;Other Genetics;overexpression;oxaliplatin;Paclitaxel;Pain;Pathogenesis;Pathway interactions;Patients;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phosphotransferases;Plasma;prevent;Prevention;Prevention strategy;Process;programs;Proteins;Quality of life;Safety;selective expression;side effect;Spinal Puncture;Sterility;success;Symptoms;Therapeutic;Tissues;Toll-like receptors;Toxic effect;Translating;Translations;treatment duration;treatment strategy;tumor progression;Vincristine;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Developing mechanism-based strategies to treat chemotherapy-induced peripheral neuropathy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Extracellular polysaccharides are produced by many organisms and perform a plethora of essential functions in life. The polymers can also protect many pathogens, thereby supporting survival inside the host. Our research seeks to unravel how extracellular polysaccharides are synthesized and deposited on the cell surface.

PI_NAMEs: ZIMMER, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Architecture;ATP-Binding Cassette Transporters;Bacteria;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Models;biomaterial development;Biophysics;Biopolymers;Carbohydrates;Cell Communication;Cell surface;Cells;Cellulose;cellulose synthase;Complex;Cryoelectron Microscopy;Deposition;drug development;Enterobacteriaceae;Enzymes;Escherichia coli;extracellular;Extracellular Matrix;Fortification;Glucans;Glycobiology;Gram-Negative Bacteria;Health;Human;human pathogen;Hydrophobicity;In Vitro;insight;Life;Lipids;Lipopolysaccharides;Mediating;Membrane;microbial;Microbial Biofilms;Molecular;Molecular Biology;Molecular Weight;Nosocomial Infections;novel therapeutics;O Antigens;Organism;Osmoregulation;pathogen;Pathologic Processes;Pathway interactions;periplasm;phosphoethanolamine;Physiological Processes;Plants;Play;Polymers;polypeptide;Polysaccharides;Process;reconstitution;Research;Roentgen Rays;Role;structural biology;Structure;System;Teichoic Acids;Viral;Virulence Factors;Water

PROJECT_TITLE: Synthesis, secretion and assembly of extracellular complex carbohydrates in Gram-negative bacteria

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE EGFR tyrosine kinase inhibitors (TKIs) are effective in many EGFR-mutated non small-cell lung cancer patients but not curative and always followed by the development of acquired resistance, most often a lethal event. We have uncovered a key step in this process and propose to use this insight to better understand how lung tumor cells resist drug treatment and define a new therapeutic approaches. Our goal is to use laboratory insights to improve care for lung cancer patients.

PI_NAMEs: BIVONA, TREVER G (contact)

PROJECT_TERMS: Acute;acute stress;Address;Animals;Apoptosis;aurora kinase;aurora kinase A;BCL2L11 gene;Biological;biological adaptation to stress;Cancer Biology;Cancer Patient;Caring;Catalysis;Cell Line;Cell Survival;Cells;clinical translation;Clinical Trials;Complex;Data;de novo mutation;Development;Disease Reservoirs;DNA;DNA Sequence Alteration;Drug resistance;Drug Tolerance;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;erbB Genes;Event;Evolution;Frequencies;Generations;Genetic;genetic evolution;Genomic Instability;Genotoxic Stress;Goals;Heterogeneity;Hyperactivity;improved;In Situ Hybridization;In Vitro;in vivo;Induction of Apoptosis;inhibitor;innovation;insight;kinase inhibitor;Knowledge;Laboratories;Lesion;live cell imaging;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;MAP Kinase Gene;Mitotic;Mitotic Activity;Modeling;Molecular;mouse model;mutant;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenes;Oncology;Organoids;Other Genetics;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phosphotransferases;Play;prevent;Process;Proteomics;research clinical testing;Residual Neoplasm;Resistance;response;Role;Sampling;Seminal;sensor;Sequential Treatment;Shapes;Signal Transduction;single cell analysis;Source;stem;Stress;stress kinase;Systems Biology;targeted treatment;Testing;Therapeutic;treatment strategy;trial planning;tumor;tumor heterogeneity;Tumor Promotion;Tumor Stem Cells;Tyrosine Kinase Inhibitor;Withdrawal

PROJECT_TITLE: Stress responses drive resistance and shape tumor evolution in EGFR mutant lung cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]