NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative Emerging ‘superbugs’, which are resistant to multiple antimicrobials, pose a daunting threat to current treatment protocols. Acinetobacter baumannii can develop multidrug resistance without acquisition of new resistance genes. Basic characterization of the underlying intrinsic resistance mechanisms will guide new antimicrobial development and improve current therapeutic treatment protocols. Therefore, this work is relevant to NIH mission to pursue fundamental knowledge, to reduce the burden of human illness and combat emerging threats to global public health.

PI_NAMEs: BOLL, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acinetobacter baumannii;anti-microbial tolerance;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;Bacteremia;carbapenem resistance;cell envelope;Cell Wall;Colistin;colistin resistance;combat;combinatorial;Compensation;Defect;design;Development;Enzymes;extensive drug resistance;Fostering;Gram-Negative Bacteria;Hospitals;Human;human disease;improved;Infection;Intrinsic factor;Knowledge;Link;Membrane;membrane assembly;Mission;Modeling;Modification;Multi-Drug Resistance;Nosocomial Infections;pathogen;Peptidoglycan;Pharmaceutical Preparations;Phenotype;Public Health;Regimen;Resistance;resistance gene;resistance mechanism;response;Stress;Superbug;Therapeutic;Treatment Protocols;United States National Institutes of Health;Urinary tract;Work;Wound Infection

PROJECT_TITLE: Reinforcing the barrier: Understanding how cell envelope modifications promote intrinsic antimicrobial tolerance and resistance in Acinetobacter baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The mechanisms controlling the transition from acute to chronic pain are not well understood, but many lines of evidence support the wasabi receptor, TRPA1 is involved in this process. These projects seek to determine how a novel gain-of-function TRPA1 mutation confers channel hyperactivity and the mechanism of calcium regulation of TRPA1 by an interplay of direct calcium binding and calmodulin. These studies will provide a greater understanding of TRPA1 regulation and may uncover new avenues for rational drug development to treat chronic pain and inflammation with non-addictive therapeutics.

PI_NAMEs: PAULSEN, CANDICE ELAINE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;Afferent Neurons;airway inflammation;Asthma;Basic Science;Binding;Binding Sites;Biochemical;Biophysics;Calcium;Calcium Binding;Calmodulin;Cations;Chemicals;chronic pain;chronic pain management;Cues;Data;Development;Disease;drug development;G-Protein-Coupled Receptors;gain of function;gain of function mutation;Genetic;Human;Hyperactivity;Hypersensitivity;Inflammation;Inflammatory;Irritants;Laboratories;Mechanics;Mediating;Modeling;Molecular;Mus;mutant;Mutation;new therapeutic target;novel;Pain;pain chronification;pain perception;Process;protein protein interaction;Proteins;receptor;Regulation;Research;Resolution;Role;Sampling;Second Messenger Systems;sensor;Stimulus;structural biology;Structure;Therapeutic;tissue injury;Wasabia;Work

PROJECT_TITLE: Molecular mechanisms of TRPA1 regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurosciences

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Successful memory for future actions is essential to adults’ capacity to engage in health and safety-related activities (e.g., remembering to take medication). Unfortunately, limited knowledge exists regarding the processes that couples employ as they navigate both normative (e.g., forgetfulness) and non-normative (i.e., mild cognitive impairment, dementia) cognitive aging, thereby impeding intervention development. This research investigates the biobehavioral pathways (i.e., physiological stress response, behaviors, and social processes) which positively and negatively impact middle-aged and older spouses’ prospective memory performance in order to achieve long-range intervention outcomes that will: positively impact couple resiliency, reduce everyday memory failures, and ultimately allow more older adults to age in place.

PI_NAMEs: MARGRETT, JENNIFER ANN (contact);MELANCON, CELINDA REESE

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adult;Affect;Age;aging in place;Autonomic nervous system;Behavior;Behavior Therapy;Behavioral;behavioral response;Belief;biobehavior;biological adaptation to stress;Biological Markers;Characteristics;Clinical;clinical practice;Cognitive;cognitive ability;Cognitive aging;cognitive change;cognitive development;cognitive performance;cognitive process;cognitive task;Collaborations;Compensation;Complex;Couples;Data;Dementia;Development;Diagnosis;Ecological momentary assessment;Emotions;Environment;Exhibits;experience;Failure;Future;Goals;Health;Home;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Independent Living;indexing;Individual;Influentials;innovation;Intervention;Investigation;Knowledge;Laboratories;late life;Life;Measurement;Measures;member;Memory;middle age;mild cognitive impairment;older adult;Outcome;Pathway interactions;Perception;Performance;Persons;Pharmaceutical Preparations;Physiological;Physiological Processes;Play;Process;prospective memory;Research;Research Personnel;resilience;Resources;Retrieval;Role;Safety;Salivary;skills;social;Social Processes;Source;Spouses;Stress;success;System;Testing;therapy development;tutoring;Work

PROJECT_TITLE: The Role of Spousal Biobehavioral Co-regulation in Everyday Collaborative Memory: Identifying Targets for Intervention

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Palliative Care

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: Patients with chronic kidney disease (CKD) live with many supportive care needs, yet the supportive care specialty remains poorly integrated into CKD care. This project describes the current state of dissemination of supportive care in pre-dialysis CKD care, its association with patient centered outcomes, and tests the effectiveness of integrating supportive care into CKD care. The information obtained from this study will provide important knowledge of approaches to care that have the potential to improve quality of life, outcomes, and satisfaction with care for CKD patients.

PI_NAMEs: SCHERER, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Advance Care Planning;Affect;American;Award;career;Caring;Chronic Care;Chronic Kidney Failure;Clinic;clinical training;clinical trial analysis;Clinical Trials;Communities;Comparative Effectiveness Research;comparison group;Complex;Control Groups;Data;Databases;Decision Making;demographics;design;Dialysis procedure;Disease Outcome;Disparity;disparity reduction;Effectiveness;effectiveness testing;end of life care;Epidemic;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Face;Failure;Foundations;Goals;Health;health care disparity;Health Services Accessibility;Hospitals;implementation science;improved;improved outcome;innovation;Institution;integrated care;International;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Learning;Medical;medical specialties;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;minority communities;minority patient;Modeling;mortality;multi-ethnic;Multicenter Trials;Nephrology;Outcome;outcome disparities;Outcome Measure;Palliative Care;Participant;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pattern;Phase;Pilot Projects;Population;Positioning Attribute;Process;Provider;Public Health;Quality of life;racial diversity;racial minority population;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resources;response;safety net;satisfaction;skills;skills training;standard of care;Structure;Supportive care;Symptom Burden;symptom management;symptomatic improvement;Testing;Time;Training;treatment arm;treatment choice;Uncertainty;United States;usual care arm;Work

PROJECT_TITLE: Supportive Care in Kidney Disease: Scope of Practice and Pilot Study of Implementation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Nerve cells control behavior and metabolism through the release of signaling molecules that are packaged in specialized compartments called dense-core vesicles, and abnormalities in the release of these molecules contributes to a wide range of mental disorders. It is common for individual neurons to carry multiple types of these signaling molecules, but it is generally not known whether they are stored and released together or separately in different dense-core vesicles. This exploratory study will begin to dissect the mechanisms by which neurons generate multiple types of dense-core vesicles, which should provide insights into the roles of these signaling molecules in normal physiology and disease.

PI_NAMEs: AILION, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Afferent Neurons;Behavior;Behavior Control;Behavior Disorders;Beta Cell;Biogenesis;Biogenic Amines;Biological;Biological Models;Black Box;Caenorhabditis elegans;Calcium;Cell Line;cell type;Cells;Cellular biology;Characteristics;Data;Defect;Dense Core Vesicle;Disease;Dopamine;Electron Microscopy;Endocrine;Endosomes;experimental study;Family;Functional disorder;Future;Generations;Heterogeneity;Individual;insight;Insulin;Investigation;Knowledge;Lipids;member;Mental disorders;Metabolic Diseases;Metabolism;Molecular;monoamine;Mood Disorders;Nematoda;Nerve Growth Factors;Nervous System Disorder;Neurologic;Neuromodulator;Neurons;Neuropeptides;Norepinephrine;Organelles;Pathway interactions;Pattern;peptide hormone;Peptides;Physiological;Physiology;Population;Process;protein complex;Protein Isoforms;Proteins;rab GTP-Binding Proteins;Rattus;Recycling;Role;segregation;sensor;Sensory;Signaling Molecule;Site;Sorting;Structure of beta Cell of islet;synaptotagmin;System;Testing;Vesicle;vesicular release

PROJECT_TITLE: Exploring how cells generate and release distinct subpopulations of dense-core vesicles

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GALVESTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Multiple cohort clinical studies demonstrate that visual-impairment diseases including glaucoma and cataract increase risk of developing dementia and AD, and cataract extraction is significantly associated with lower risk of dementia development. However, conflicting studies remain. Our proposed studies aim to use well- controlled animal experiments to test the hypothesis that visual impairment accelerates tauopathy in the brain.

PI_NAMEs: XIA, FAN ;ZHANG, WENBO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Abbreviations;Acceleration;Affect;Age;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Anatomy;Animal Experiments;Atrophic;Attenuated;Axon;Axonal Transport;base;Blindness;Brain;Brain region;Cataract;Cataract Extraction;Cells;Central Nervous System;Cerebrospinal Fluid;Clinical Research;Cognitive;cohort;Confounding Factors (Epidemiology);Consensus;corticobasal degeneration;Darkness;Dementia;dementia risk;Deposition;Development;Diagnostic;Disease;Electroretinography;Excitatory Postsynaptic Potentials;excitotoxicity;Eye;Family member;Fiber;Financial cost;Foundations;FTD with parkinsonism;Functional disorder;Glaucoma;glial activation;Gliosis;Hippocampus;Human;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;Impairment;injured;Injury;Investigation;Knowledge;Lateral Geniculate Body;Life;Link;Long-Term Potentiation;Mediating;member;Memory Loss;Microtubule Stabilization;Microtubule-Associated Proteins;Modeling;Monoclonal Antibodies;mouse model;N-Methylaspartate;neovascular;Nerve Degeneration;neural network;Neurodegenerative Disorders;Neuronal Dysfunction;Neuronal Injury;Neurons;novel;object recognition;Pathologic;Pathology;Pathway interactions;Patients;Phosphate Buffer;Physiologic Intraocular Pressure;Pick Disease of the Brain;Play;polymerization;Polymers;preclinical study;prevent;Progressive Supranuclear Palsy;Protein Family;psychosocial;Reporting;Research Personnel;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal nerve fiber layer;retinal neuron;Risk;Role;Saline;sensory system;Societies;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Thinness;Time;Vision;Visual;visual deprivation;Visual impairment;Visual Pathways

PROJECT_TITLE: Does Vision Loss Affect Tauopathy in the Brain

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Neurosciences;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Stroke;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE HIV and cocaine use are strongly linked to stroke, but substance use outside of alcohol and tobacco are not included in stroke risk calculators, even those adapted for people living with HIV (PLWH). Whether including the use of cocaine would improve the detection of people at the highest risk for stroke is unknown. We propose a study to determine the simultaneous influences of cocaine, polysubstance use, inflammation and traditional risk factors on stroke and cerebrovascular conditions that directly precede stroke.

PI_NAMEs: RILEY, ELISE D. (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acute;Address;Age;Alcohol consumption;Alcohols;amphetamine use;Amphetamines;antiretroviral therapy;Biological Markers;C-reactive protein;Cannabis;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;CD4 Lymphocyte Count;cerebrovascular;Chronic;Clinic;Clinical;cocaethylene;Cocaine;cocaine use;Cocaine use disorder;Communities;Data;Detection;Diagnosis;disability;Drug abuse;Drug usage;Failure;Functional disorder;Goals;high risk;HIV;HIV Infections;HIV/AIDS;Homelessness;housing instability;improved;Individual;Infarction;Inflammation;Inflammatory;inflammatory marker;insight;Levamisole;Lidocaine;Link;Low Income Population;Magnetic Resonance Imaging;Measures;Methadone;Microvascular Dysfunction;Modernization;mortality;multiple drug use;Opioid;Opioid Analgesics;Pathway interactions;Patient Recruitments;Patient Self-Report;Persons;Pharmaceutical Preparations;Pilot Projects;polysubstance use;predictive marker;Preventive;Reaction;Recording of previous events;recruit;Research;response;Risk;Risk Assessment;Risk Factors;risk stratification;safety net;Stroke;stroke risk;stroke-like episode;substance use;Time;Tobacco;Tobacco use;tool;Toxicology;Viral;Viral Load result;Woman

PROJECT_TITLE: Cocaine use, viral suppression and precursors of stroke in HIV infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Services;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Women who have experienced hypertensive disorders in pregnancy are at significantly elevated risk of future cardiovascular disease. However, a substantial proportion of these women do not transition to primary care in the postpartum year for ongoing cardiovascular disease risk management and those who do may receive suboptimal care that does not adequately address this heightened risk. The proposed study will examine how systems factors, including insurance dynamics and features of healthcare organizations, shape use of primary care and the care received in this setting in the postpartum year using a mixed methods approach. Findings will contribute to an improved understanding of system factors associated with successful transition to postpartum primary care for women at high cardiovascular disease risk, and help to identify interventions, healthcare quality metrics, and policy levers to improve clinical practice.

PI_NAMEs: ATTANASIO, LAURA B;GEISSLER, KIMBERLEY LYNN H (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;adverse outcome;Birth;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Caring;Cause of Death;Characteristics;child bearing;Chronic;Cigarette;clinical practice;contextual factors;critical period;design;Diagnostic;Dimensions;Discipline of obstetrics;Eclampsia;Enhancers;experience;Face;Family history of;Funding;Future;Health;health care quality;health care service organization;health difference;Health system;Healthcare;Heart failure;high risk;Hyperlipidemia;Hypertension;hypertension treatment;improved;Insurance;interest;Intervention;Interview;Knowledge;Life Cycle Stages;Managed Care;Massachusetts;maternal morbidity;Maternal Mortality;medical specialties;Metabolic syndrome;Methods;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Patients;Pattern;Performance;perinatal women;pharmacologic;Policies;policy recommendation;Population;postpartum care;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Preventive;Primary Care;primary care clinician;Process;Qualifying;Quality of Care;Recommendation;Recording of previous events;Research;Research Personnel;Risk;Risk Assessment;Risk Management;Role;Sampling;sex;Shapes;Site;Smoking;Stroke;Structure;System;United States;Woman;women of color;Women's mortality;Work

PROJECT_TITLE: System factors influencing the postpartum transition to primary care for cardiovascular disease risk management among women with hypertensive disorders in pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative – Overall Component The Nutrition Obesity Research Center (NORC) at the University of North Carolina at Chapel Hill (UNC) takes as its central theme “Interdisciplinary Nutrition Research: From Molecules to Public Health.” We propose an Administrative Core and four biomedical research cores: the Animal Metabolism Phenotyping Core, the Clinical and Community Human Assessment and Interventions Core, the Metabolism and Metabolomics Core, and the Precision Nutrition Core. As an integrated whole, the UNC NORC will provide the framework, tools, and expertise investigators need to engage in the interdisciplinary research required to improve health outcomes.

PI_NAMEs: MAYER-DAVIS, ELIZABETH J (contact);SHAIKH, SAAME R

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: analytical tool;Animals;Assessment tool;Award;base;Basic Science;Behavior;behavior change;Behavior Therapy;Biochemical;Biological Markers;Biomedical Research;career;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community based research;Complex;cost effective;Data Analyses;Diet;digital intervention;Discipline;Doctor of Philosophy;Education;Effectiveness;Epidemiology;epidemiology study;Equipment;Fostering;Funding;General Population;genetic makeup;Grant;Health;Health Professional;Human;improved;Individual;Infrastructure;innovation;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Intervention Studies;Investments;Laboratory Finding;Language;Leadership;member;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Methods;microbiome analysis;Mission;Molecular;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;novel strategies;nutrition;nutrition related genetics;Nutritional Study;Obesity;Outcome;Peer Review;Phenotype;Physicians;Policy Maker;Population;population based;precision nutrition;Problem Solving;programs;Public Health;public health research;Publications;Research;Research Methodology;Research Personnel;Resources;Risk;role model;Scientist;Services;Social Sciences;success;synergism;Techniques;tool;Training;Translating;Translation Process;Translational Research;United States National Institutes of Health;Universities;Variant;Work


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE With age, most stem cells lose their ability to adequately replace damaged tissue cells and respond to tissue regenerative needs, but the causes of this loss in potency remain unclear. Goal of this project is to use the negligibly senescent planarian stem cell system to identify the role of transposon silencing and chromatin maintenance in their ability to avoid age-related changes. This project will contribute to a better understanding of the biology of aging, and to the identification of new strategies to improve the human health span.

PI_NAMEs: VAN WOLFSWINKEL, JOSEPHINA C (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Address;Adult;adult stem cell;Affect;Age;age acceleration;age related;age related biomarkers;age related changes;aged;Aging;aging biomarker;Animals;Appearance;ATAC-seq;Attention;Biological Models;Biology of Aging;cell age;Cell Differentiation process;Cell Maintenance;Cells;Chemicals;Chromatin;chromatin modification;Complex;cost;derepression;Development;DNA Transposable Elements;driving force;Epigenetic Process;functional decline;Functional disorder;genomic locus;Genomics;Goals;Health;Healthcare Systems;healthspan;Human;human stem cells;improved;in vivo;insight;Life;life span;Maintenance;Measures;Mediating;Mobile Genetic Elements;Molecular;mortality;Pathway interactions;Phenotype;piRNA;Planarians;Play;Population;Process;Proteins;rate of aging;rate of change;regenerative;regenerative tissue;Regulation;Repression;Resistance;RNA;RNA Interference;Role;senescence;Specimen;stem cell aging;stem cell population;stem cells;Stereotyping;System;Time;Tissue Differentiation;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Role of transposon regulation in the negligible senescence of S. mediterranea


NIH_SPENDING_CATS: Nutrition;Obesity

PI_NAMEs: MAYER-DAVIS, ELIZABETH J (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;American;Applications Grants;Award;base;Basic Science;Budgets;career development;Centers for Disease Control and Prevention (U.S.);Chairperson;Clinical;Collaborations;Collection;Communication;Communities;Consult;Department chair;Educational workshop;Effectiveness;Eligibility Determination;Ensure;Epidemiology;experience;Faculty;Fostering;Funding;Future;General Population;Health;Human Resources;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Intervention;Investments;Lead;Leadership;Measures;Medical Students;meetings;member;Methods;Mission;Monitor;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;nutrition;nutrition education;Nutritional Study;Obesity;Occupational activity of managing finances;operation;Outcome;Physicians;Play;Policy Compliance;Process;Productivity;programs;Publications;Quality Control;Records;recruit;Reporting;Reproducibility;Research;Research Personnel;Resources;Role;Science;Scientist;SEARCH for Diabetes in Youth;Services;Societies;Strategic Planning;Students;success;symposium;System;tool;Training;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative This proposal employs LC-MS technology and flow cytometry to identify MR1-bound metabolites derived from a leading pathogen of global importance, Mycobacterium tuberculosis (Mtb). The investigators will define the effects of these metabolites on MR1 expression and MAIT cell activity after initial Mtb exposure and infection in humans.

PI_NAMEs: VORKAS, CHARLES KYRIAKOS (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Anabolism;Antigen Presentation;Antigen-Presenting Cells;Antigens;Bacteria;Binding;Biological;Biological Assay;Blood;Candida;Cell Physiology;Cells;Cellular biology;Chronic;Clinical;Clone Cells;cohort;Collaborations;Communities;CRISPR interference;cytotoxic;Data;Disease;Event;experience;Exposure to;Flow Cytometry;Future;Genetic;Genus Mycobacterium;Granzyme;Haitian;Household;Human;Immune;Immune Evasion;Immune Targeting;Immunity;Immunology;Immunotherapy;improved;In Vitro;in vivo;Infection;insight;Interferons;knock-down;Laboratories;Laboratory Study;Legionella;Ligands;liquid chromatography mass spectrometry;Lymphocyte;Lymphocyte Biology;Lymphocyte Function;Measures;Metabolism;metabolome;metabolomics;Microbe;microbial;Morbidity - disease rate;mortality;mucosal vaccine;Mucous Membrane;Mus;mutant;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;novel;pathogen;Patients;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;Plasma;Preventive vaccine;protein purification;Proteins;receptor;recruit;Research;research clinical testing;Research Personnel;response;Riboflavin;Salmonella;Sampling;Source;System;T-Cell Activation;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;Technology;transmission process;Tuberculosis;Vaccines;Vitamin B Complex;Work

PROJECT_TITLE: Identification of Mycobacterium tuberculosis-derived metabolites acting as ligands for MR1-restricted T cells.


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Understanding the mechanisms that govern reproductive aging will have a positive impact on human health. This proposal focuses on characterizing how ribosomes and changes in mRNA translation impact the quality of stored eggs. We believe this work will reveal new and exciting principles in cell biology and molecular biology.

PI_NAMEs: BUSZCZAK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Adopted;Affect;Age;age related;age related changes;age related decline;Aging;Biochemical;biochemical model;Biogenesis;Biological Assay;Cell Physiology;Cells;Cellular biology;Complex;Congenital Abnormality;Data;Defect;Disease;Drosophila genus;egg;Embryonic Development;Exhibits;experience;experimental study;Female;female reproductive system;fly;gain of function;Gene Modified;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;genomic locus;Germ Cells;Goals;Growth;Health;Homeostasis;Human;Hydroxylation;improved;in vivo;in vivo evaluation;Incidence;innovation;insight;Intervention;Knock-out;Length;Link;loss of function;Mammals;Maternal Age;Messenger RNA;Modeling;Modification;Molecular;Molecular Biology;Molecular Target;mRNA Translation;Natural regeneration;oocyte quality;Oocytes;Oogenesis;Organelles;Organism;Ovarian aging;Ovary;Oxidation-Reduction;Oxygenases;paralogous gene;Phenotype;Physiological;Play;Post-Translational Protein Processing;Process;Production;Protein Biosynthesis;Proteins;proteostasis;Publishing;Reagent;Reporter;Reproduction;Reproductive Health;Reproductive Process;reproductive senescence;reproductive success;response;Ribosomal Proteins;Ribosomal RNA;Ribosomes;Risk Factors;Role;Signal Transduction;Spontaneous abortion;Study models;System;Techniques;Technology;Testing;therapy design/development;Time;Tissues;tool;Transcript;translation factor;Translation Initiation;translational impact;Translations;Work

PROJECT_TITLE: Characterization of how mRNA translation influences reproductive aging

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity;Prevention

PI_NAMEs: HURSTING, STEPHEN D (contact)

PROJECT_TERMS: Animals;Appalachian Region;Area;Biological Assay;Biological Models;Biomedical Research;Body Weight;Calibration;Calorimetry;Cell model;cell type;Cells;Chills;clinically relevant;Collection;Communities;Computers and Advanced Instrumentation;Data Analyses;Dedications;Development;Diet;Disease;disease phenotype;Documentation;endurance exercise;energy balance;Energy Intake;Ensure;Exercise;Experimental Designs;experimental study;Fatty acid glycerol esters;Feces;feeding;Food Preferences;Funding;genetic manipulation;Genetic Medicine;Genetic Techniques;Genetically Engineered Mouse;Genomics;Genus Hippocampus;Goals;Grant;Guidelines;Home;Human;IACUC;Individual;Industry;industry partner;Infrastructure;Institution;instrumentation;Intervention;Maintenance;Measurement;member;metabolic phenotype;metabolic rate;Metabolism;metabolomics;Methods;microbiome analysis;Mitochondria;Modeling;mouse model;Mus;next generation;North Carolina;Nutrient;nutrition;Nutritional;Nutritional Study;Obesity;Obesity associated disease;Phenotype;Population;pre-clinical research;Process;programs;Publications;Quality Control;Reproducibility;Research;Research Institute;Research Personnel;Resolution;Resources;response;Schedule;Services;Site;Spirometry;Study models;Technology;Therapeutic;Thinness;Time;Training;translational scientist;Universities;Urine

PROJECT_TITLE: Animal Metabolism Phenotyping Core


NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: PHYSICS

ORG_NAME: NEW YORK UNIVERSITY

PHR: Narrative: Our aim is to elucidate the connection between the gene-level and genome-wide motions of human genome inside the cell nucleus in live cells in real time. By answering such a fundamental question we will learn new biology and physics underlying the dynamics of the human genome, which is critical for gene regulation, cell homeostasis and healthy development. Such knowledge will lead to a new, mechanistic picture of the dynamic self-organization of the human genome, contributing to current efforts to understand mechanisms of cancer, diabetes and developmental disorders.

PI_NAMEs: ZIDOVSKA, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Algorithms;ATP phosphohydrolase;Biochemical;Biochemistry;Biological;Biology;Cell Differentiation process;Cell Nucleus;Cells;Chromatin;Chromosome Mapping;Chromosome Territory;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Confocal Microscopy;Coupled;Coupling;Cytoskeleton;Data Analytics;Data Collection;Data Set;Development;developmental disease;Diabetes Mellitus;DNA Packaging;DNA Repair;DNA-Directed DNA Polymerase;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genome Mappings;genome-wide;genomic locus;Genomics;Goals;Heterogeneity;Histone H2B;Homeostasis;Human Genome;IL6 gene;Image;in vivo;Individual;Interphase;Knowledge;Laws;Learning;Length;Link;Machine Learning;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Measures;Methods;Molecular Biology Techniques;Monitor;Motion;Mouse Embryonic Stem Cells;Movement;Nature;Neurons;Nuclear;Paint;particle;physical science;Physics;Polymers;Process;Property;Research;Rheology;RNA Polymerase II;Role;segregation;self organization;Site;spatiotemporal;Spectrum Analysis;stem cell differentiation;Structure;System;Technology;temporal measurement;Time;tool;Topoisomerase II;Transport Process;Visualization;whole genome

PROJECT_TITLE: In vivo spatiotemporal mapping of genome-wide motions and gene-level transcriptional activity via integrated experimental platform and data-analytical pipeline

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Microbiome;Patient Safety;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative: The goal of this proposal is to develop a system for collecting exhaled aerosols from mechanically ventilated patients and to determine if these aerosols can be used to detect ventilator associated pneumonia and identify the associated pathogen.

PI_NAMEs: CORCORAN, TIMOTHY E (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;acute infection;Acute Respiratory Distress Syndrome;Aerosols;Albumins;aspirate;bacterial community;Bacterial Infections;Biological;Biological Assay;Biological Markers;Bronchoalveolar Lavage;candidate marker;Chronic Obstructive Pulmonary Disease;clinical decision-making;Collection;Communities;Complex;Complication;COVID-19;cytokine;design;Detection;Devices;Diagnosis;Distal;dysbiosis;Early Diagnosis;Early identification;effective therapy;endothelial dysfunction;Endothelium;endotracheal;Epithelium;Etiology;Evolution;Exhalation;experimental study;Functional disorder;GDF15 gene;Genetic Transcription;Goals;Human;idiopathic pulmonary fibrosis;IL8 gene;Immune response;Infection;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;Interleukin-6;Label;Lung;Lung infections;lung injury;lung microbiome;Measurement;Measures;Mechanical ventilation;member;Metagenomics;Methods;microbial;Modeling;pathogen;Pathogen detection;Patients;Performance;Perfusion;Permeability;Pneumonia;potential biomarker;procalcitonin;PTX3 protein;Pulmonary Edema;Radiolabeled;Recovery;respiratory;respiratory aerosol;Respiratory Failure;rRNA Genes;sample collection;Sampling;Surveys;System;systemic inflammatory response;Techniques;Testing;TNFRSF1A gene;Tube;ventilation;Ventilator;ventilator-associated pneumonia;Viral

PROJECT_TITLE: Early detection and identification of ventilator associated pneumonia

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Liver Disease;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is a devastating complication of cirrhosis with heterogeneous presentations and suboptimal responses to therapy. Volume resuscitation with intravenous albumin is recommended as first-line treatment for all AKI in cirrhosis, though clinicians require additional guidance to distinguish between those who may be harmed by resuscitation (i.e., patients with pre-existing intravascular overload and/or features suggesting high risk of lung vascular leakage) from those who would benefit. In this proposal, we aim to define predictors of renal response to treatment and better personalize IV albumin dosing by introducing an inexpensive and reliable measurement of intravascular volume into the treatment algorithm for AKI in cirrhosis, thus optimizing existing therapies and improving outcomes for this high-risk population.

PI_NAMEs: ALLEGRETTI, ANDREW S (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adverse effects;Affect;Albumins;Algorithms;Angiopoietin-2;Assessment tool;Award;biobank;Biological;Biology;Blinded;Blood capillaries;Blood Vessels;care providers;career;Cirrhosis;Clinical;Clinical Data;Clinical Trials;comparison group;Complication;Creatinine;Critical Care;Critical Illness;Data;Development;Diagnosis;Dose;Endothelium;Event;Extravasation;FDA approved;Fostering;Functional disorder;Future;Guidelines;hemodynamics;Hepatology;high risk;high risk population;improved;improved outcome;Individual;Inflammation;Infrastructure;Injury;Injury to Kidney;insight;Intervention;Intravenous;K-Series Research Career Programs;Kidney;Literature;Lung;Measurement;Measures;Methodology;Molecular;molecular marker;Monitor;Multicenter Trials;Nephrology;open label;Outcome;Pathway interactions;Patients;Pattern;Perfusion;personalized medicine;Phenotype;Physiological;Pilot Projects;pilot trial;point of care;Population;prognostic;Publishing;Pulmonary Edema;Randomized;Recommendation;Renal function;Research;Respiratory Failure;response;Resuscitation;Sampling;Serum;skills;standard care;standard of care;Syndrome;systemic inflammatory response;Techniques;Therapeutic;therapy outcome;Time;tool;Training;Treatment Protocols;treatment response;trial design;trial enrollment;ultrasound;Universities;vascular inflammation;Work

PROJECT_TITLE: Personalizing Therapies for Acute Kidney Injury in Cirrhosis


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Nearly 6% of the US adult population meets criteria for Alcohol Use Disorder (AUD), yet few effective, long- term treatments are currently available. Glycogen synthase kinase 3 beta (GSK3B) has been implicated in ethanol behaviors through microarray, gene targeting, and pharmacological inhibition experiments, and as such poses as a potential therapeutic target in the treatment of AUD. We propose to further investigate the role of GSK3B in ethanol consumption by identifying precise cell types of interest and its regulation throughout the shift from initial ethanol exposure through progressive, chronic consumption.

PI_NAMEs: GOTTLIEB, SAMANTHA ANN (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Adult;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol response;alcohol risk;alcohol use disorder;Alcohols;Anatomy;Animals;Brain region;cell type;Cells;Chronic;chronic alcohol ingestion;Complex;Consumption;Country;delivery vehicle;Development;drinking;drinking behavior;Environment;Ethanol;Etiology;experimental study;FDA approved;Gene Activation;gene network;Gene Targeting;Genes;Genetic;Genetic Models;Genetic Recombination;genome wide association study;genome-wide;glycogen synthase kinase 3 beta;Human Genome;Immediate-Early Genes;Immunohistochemistry;interest;Investigation;Knock-out;Knowledge;Label;Laboratories;Location;LoxP-flanked allele;Measures;Medial;member;Methods;mouse genetics;Mus;neural;Neurobiology;Neurons;new therapeutic target;Nucleus Accumbens;overexpression;Pathway interactions;pharmacologic;Phosphorylation;Population;Prefrontal Cortex;preventable death;Prosencephalon;Protein Kinase;Public Health;Regulation;Research;response;Rodent;Role;Serine;Site;Specificity;Stains;Therapeutic Agents;therapeutic target;United States;United States Substance Abuse and Mental Health Services Administration;Viral;Viral Vector;Virus

PROJECT_TITLE: The Role of GSK3B in Progressive Alcohol Consumption


NIH_SPENDING_CATS: Behavioral and Social Science;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Telehealth

PI_NAMEs: TATE, DEBORAH F. (contact)

PROJECT_TERMS: Acceleration;Appearance;Area;Behavior assessment;behavior change;behavior measurement;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral Research;Biolectric Impedance;Body Composition;Body measure procedure;Calorimetry;Certification;Chemicals;Client;Clinical;Clinical assessments;Clinical Protocols;Clinical Research;Clinical Trials;Code;Collaborations;Communication;Communities;community research;Complex;Computer software;Consultations;Consumption;cost effective;Data;Data Analyses;Data Collection;data quality;Decision Aid;design;Development;Diet;dietary;Dietary Intervention;digital health;digital media;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Educational workshop;eHealth;Ensure;Epidemiology;epidemiology study;Equipment;Etiology;experience;Experimental Designs;Feedback;Focus Groups;Food;Food production;Frequencies;Funding;Goals;Grant;Health;Hour;Human;implementation facilitation;Information Systems;Infrastructure;innovation;Institution;Internet;Intervention;Intervention Studies;Interview;Laboratories;Leadership;Manuscripts;Measures;member;Metabolic;Metabolism;Methodology;Methods;mobile app development;mobile application;mobile computing;Modification;Multimedia;Nutrient;nutrition;Nutrition Assessment;Obesity;obesity prevention;obesity treatment;Pamphlets;Participant;Periodicals;Pharmacy facility;Physical activity;Population;Preparation;Printing;Protocols documentation;Publications;Qualitative Research;Questionnaires;Recipe;Recommendation;Records;recruit;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Sampling;Schedule;Science;Scientist;Services;smartphone application;Specific qualifier value;Specimen;Surveys;systems research;tailored messaging;Taste Perception;Technical Expertise;Techniques;Testing;therapy development;Training;United States National Institutes of Health;usability;Venous blood sampling;web app;web site;Work

PROJECT_TITLE: Clinical and Community Human Assessment and Interventions Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Life-threatening arrhythmia in the setting of QT prolongation commonly occurs as a consequence of drugs that affect cardiac repolarization. While cardiomyocyte mishandling of calcium leads to contractile dysfunction and arrhythmia, the integrative understanding of drug-induced excitation-contraction coupling abnormalities remains to be defined. For this reason, we seek to integrate our genetic models with advanced imaging and computational methods to investigate if a common mechanism of action underlies small molecule compounds-induced bradycardia or if each compound works in a different way.

PI_NAMEs: DING, YICHEN  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Affect;Amiodarone;Anti-Arrhythmia Agents;anti-depressive agents;Anti-emetics;anti-fungal agents;Antibiotics;antimicrobial;Antineoplastic Agents;Apical;Arrhythmia;automated segmentation;Biological Models;Bradycardia;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cell Nucleus;Cells;Clinical;Collaborations;Complication;Computer Models;Computing Methodologies;Coupling;Custom;Developmental Biology;Embryo;Engineering;Erythromycin;Fertilization;Fishes;Fluoxetine;Four-dimensional;Functional disorder;Genetic;Genetic Models;Goals;Heart;Heart Atrium;Hour;Human;Image;image processing;imaging modality;in vivo;Individual;interest;Investigation;Life;Light;Lighting;Machine Learning;machine learning framework;Measures;Mechanics;Methodology;Microscope;Morphologic artifacts;Motion;mutant;Myocardial;Myocardial Contraction;Noise;Patients;Pattern;Penetration;Pentamidine;Pharmaceutical Preparations;Physicians;Productivity;prospective;prototype;Psychotropic Drugs;Research;Resolution;response;Risk Factors;Screening procedure;Signal Transduction;Sinoatrial Node;small molecule;spatiotemporal;Structure;success;Techniques;Testing;TG gene;Time;Transgenic Organisms;Troponin T;United States;Variant;Ventricular;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Volumetric imaging and computation to characterize cardiac electromechanical coupling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The G1 and G2 variants in the gene encoding Apolipoprotein L1 (APOL1) increase risk for developing focal segmental glomerulosclerosis (FSGS) in people with recent African ancestry, but the exact mechanisms and agents driving the pathology are still being discovered. While the pathologic mechanisms of these variants in glomerular cells are actively being studied, the role of macrophage-mediated inflammation in the development of APOL1 kidney disease is still poorly understood. The research outlined in this proposal will use congenic induced pluripotent stem cell(iPSC)-derived macrophages to elucidate the precise mechanisms that increase macrophage inflammation and subsequent kidney injury, and provide a model to study other genetic drivers of inflammation in macrophages.

PI_NAMEs: LIU, ESTHER  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Accounting;Affect;African ancestry;Agonist;AIDS-Associated Nephropathy;Anti-Inflammatory Agents;Apolipoproteins;attenuation;Automobile Driving;Autophagocytosis;Biology;biomedical scientist;Black American;Cardiovascular Diseases;cell type;Cells;Cholesterol;Chronic Kidney Failure;Clinical;comorbidity;Complex;congenic;cost;cytokine;design;Development;Disease;disease phenotype;Disease Progression;End stage renal failure;Endoplasmic Reticulum;endoplasmic reticulum stress;Exhibits;experience;Face;fatty acid oxidation;Fluorescence-Activated Cell Sorting;Focal and Segmental Glomerulosclerosis;Functional disorder;Gene Expression;General Population;Genes;Genomics;Genotype;Glycolysis;Goals;high risk;Homeostasis;Human;human induced pluripotent stem cells;Immunology;in vivo;Individual;induced pluripotent stem cell;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;inhibitor;Injury;injury and repair;Injury to Kidney;innovation;interdisciplinary approach;Interleukin-10;Kidney;Kidney Diseases;Link;lipid metabolism;Lipids;Liver X Receptor;Macrophage;Macrophage Activation;Measures;Mediating;Membrane;Membrane Proteins;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mus;Nephrology;novel therapeutics;Nuclear;Other Genetics;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Persons;pharmacologic;Phenotype;Phosphorylation;Physiology;podocyte;Population;Primates;protein expression;Regulation;Renal function;Research;Research Project Grants;Resolution;response;response to injury;Risk;Risk Factors;risk variant;Role;Signal Pathway;Signal Transduction;skills;socioeconomic disparity;Socioeconomic Factors;STAT3 gene;Techniques;Testing;tissue repair;Tissues;Transgenic Mice;United States;uptake;Variant

PROJECT_TITLE: Uncovering Mechanisms of Risk-Variant APOL1-modulated Inflammatory Signaling in Macrophages

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-G (O1)]


PI_NAMEs: HERRING, LAURA E (contact)

PROJECT_TERMS: analytical method;Biochemistry;Biological;Biological Assay;Biological Markers;Carbon;Cells;Chemicals;Clinical;Clinical Sciences;collaborative environment;Communication;Competence;Complement;cost effective;Coupled;cytokine;Data;data acquisition;Data Analyses;data quality;data repository;Development;Diet;Diet and Nutrition;Dietary Intervention;Disease;Educational workshop;Ensure;epidemiology study;Equipment;exercise intervention;experience;experimental study;Fatty Acids;Food;Functional disorder;Funding;Funding Mechanisms;genetic variant;Grant;Health;Health Services Accessibility;High Pressure Liquid Chromatography;Hour;Immunoassay;Individual;Infrastructure;instrumentation;Intake;Interdisciplinary Communication;Intervention Studies;Laboratories;Leadership;Libraries;Link;lipidomics;Liquid substance;Maps;Mass Spectrum Analysis;Measurement;member;metabolic phenotype;Metabolism;metabolomics;Metadata;Metals;Methods;Modeling;Molecular Weight;North Carolina;Nuclear Magnetic Resonance;Nutrient;nutrition;Nutritional;nutritional epidemiology;Nutritional Requirements;Nutritional status;Nutritional Study;Obesity;Online Systems;Pathway interactions;Performance;Persons;Pharmaceutical Preparations;Phenotype;Preparation;Protocols documentation;public database;Publications;Quality Control;Randomized;Reproducibility;Research;Research Design;Research Institute;Research Personnel;Resolution;Running;Sampling;Sampling Studies;Scientist;Services;Signal Transduction;Spectrum Analysis;Statistical Data Interpretation;Statistical Models;Stress;Students;System;Techniques;Technology;Testing;Tissues;Training;Training Programs;Translational Research;webinar;Weight;Work

PROJECT_TITLE: Advanced Testing in Omics using Mass Spectrometry (ATOMS)


ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: The purpose of the proposed Resource is to provide the biomedical community with access to state-of- the-art facilities for macromolecular crystallography, small-angle x-ray scattering, and x-ray spectroscopy/imaging, tools that are essential for the study of biological systems. They enable information that is prerequisite for understanding fundamentals of life, and provide methods that are central to the development of new therapeutics for human disease. The overarching goal is to provide an integrated Resource that makes mature technologies available to a broad research community, and provides researchers with expert support in their use.

PI_NAMEs: HODGSON, KEITH O (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: absorption;Automation;base;Biological;biological systems;Biomedical Research;Clinic;Collaborations;Communities;computer cluster;Computer software;computerized data processing;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;Data Collection;data quality;Dedications;Detection;detector;Development;Education and Outreach;Educational workshop;experience;experimental study;Facility Accesses;flexibility;Funding;Generations;Goals;Grant;Health;Human;human disease;Image;Individual;innovation;Institution;Instruction;instrument;instrumentation;Investments;Laboratories;Leadership;Life;Light;Measurement;Membrane Lipids;Mentors;Methodology;Methods;Molecular Biology;National Institute of General Medical Sciences;new technology;novel therapeutics;online resource;operation;outreach;outreach program;Peer Review;Performance;Privatization;Process;Productivity;programs;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Schools;Science;Services;Site;Source;spectroscopic imaging;Spectrum Analysis;structural biology;Structure;success;synchrotron radiation;Synchrotrons;Techniques;technological innovation;Technology;theories;Time;tool;Training;United States National Institutes of Health;web portal;web-based tool;Work;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: A Synchrotron Radiation Structural Biology Resource


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative Pancreatic cancer (PC) is one of the deadliest diseases with an overall 5-year survival rate of ~10%, because in most cases, particular at late stages, PC is unresectable, non-permeable to drugs, immunologically suppressive, and highly metastatic. We developed a novel interstitial localized ablative immunotherapy (iLAIT), combining local ablation and local administration of immunostimulants, which has the potential to overcome the major challenges of PC, particularly when synergized with immune checkpoint therapy (ICT). This project is to determine the efficacy and immunological mechanism of iLAIT-ICT in the treatment of metastatic pancreatic tumors in mice, laying the foundation for translating iLAIT-ICT to an effective clinical treatment modality for late-stage, metastatic pancreatic cancer patients, who face severely limited options.

PI_NAMEs: CHEN, WEI R. (contact);LI, MIN

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Ablation;absorption;Aftercare;Animals;anti-CTLA4;anti-PD-1;anti-PD-L1;Antitumor Response;cancer statistics;cancer therapy;Cells;checkpoint therapy;chemotherapy;clinical application;Clinical Treatment;Clinical Trials;clinically relevant;Combined Modality Therapy;conventional therapy;design;Development;Diagnosis;Diffusion;Disease;Disseminated Malignant Neoplasm;Distant Metastasis;Dose;draining lymph node;efficacy evaluation;fluorescence imaging;Foundations;Future;glycated chitosan;Histology;Immune;Immune checkpoint inhibitor;immune function;Immune response;Immune system;Immunity;immunogenic cell death;Immunologic Adjuvants;Immunologic Stimulation;Immunologics;Immunology procedure;Immunotherapy;Implant;improved;Infiltration;Injections;Interferons;interstitial;Intervention;Invaded;Investigation;Label;Lasers;lens;Light;Magnetic Resonance;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Maps;Melanoma;Melanoma Cell;Minor;Modality;Modeling;Modification;Monitor;Mus;neoplastic cell;novel;novel therapeutic intervention;Operative Surgical Procedures;optical fiber;Organ;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;Pharmaceutical Preparations;photothermal therapy;preclinical study;Radiation therapy;Reporting;Resistance;response;secondary lymphoid organ;single-cell RNA sequencing;spatiotemporal;Spleen;Stimulant;Stromal Cells;success;Surface;Surgical incisions;Survival Rate;synergism;T-Cell Proliferation;T-Lymphocyte;Temperature;Testing;Therapeutic Effect;Thermometry;Time;Tissues;Translating;Treatment Efficacy;treatment group;tumor;tumor ablation;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Unresectable

PROJECT_TITLE: Potentiating a systemic antitumor response by interstitial localized ablative immunotherapy to synergize with immune checkpoint therapy for metastatic pancreatic tumors

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Bioengineering

PROJECT_TERMS: absorption;Accountability;Advisory Committees;Biomedical Research;Budgets;Clinic;Communication;Communities;Computer software;Cryoelectron Microscopy;Crystallography;cyber security;Dedications;detector;Development;Education and Outreach;Educational workshop;Effectiveness;experience;experimental study;Feedback;free-electron laser;Generations;Goals;improved;Individual;innovation;instrumentation;Leadership;Light;Maintenance;Methodology;Methods;Molecular Biology;Monitor;online resource;operation;outreach;outreach program;Peer Review;Performance;Process;Productivity;programs;Progress Reports;Recording of previous events;Research;Resources;Roentgen Rays;Running;Safety;Schools;Science;Services;Site;Source;spectroscopic imaging;Strategic Planning;structural biology;success;Surveys;synchrotron radiation;Synchrotrons;Techniques;Training;trend;United States National Institutes of Health;web portal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-D]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: COHEN, AINA E. (contact)

PROJECT_TERMS: absorption;Acute;Automatic Data Processing;Automation;beamline;biological systems;Biomedical Research;Clinic;Collaborations;Collection;Communities;Complex;Computer software;computerized data processing;Coupled;Cryoelectron Microscopy;Cryopreservation;Crystallization;Crystallography;Data;Data Analyses;Data Collection;Data Set;data structure;Dedications;Dehydration;design;detector;Discipline;Documentation;Education and Outreach;Educational workshop;experience;experimental study;flexibility;Fostering;Freezing;Generations;Goals;Humidity;Ice;In Situ;Individual;innovation;Institution;Instruction;instrumentation;Internet;Investigation;lectures;Light;Location;Manuals;Measurement;Membrane Proteins;metalloenzyme;Methodology;Methods;Molecular Biology;Monitor;Multiprotein Complexes;novel;online resource;operation;outreach;outreach program;Peer Review;Performance;Process;Productivity;programs;Protein Dynamics;Publications;Radiation;Raman Spectrum Analysis;Reaction;Recording of previous events;Research;Resolution;Resources;Roentgen Rays;Running;Sampling;Schools;Science;Services;Site;software development;Source;spectroscopic imaging;structural biology;Structure;success;synchrotron radiation;Synchrotrons;System;Techniques;Technology;temperature jump;Time;tool;Training;user-friendly;Vision;web portal;x-ray free-electron laser


ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative/Public Health Relevance. Although recurrence of pain is commonly experienced by patients, its mechanisms are poorly understood and consequently there is no FDA-approved treatment to prevent the relapse to pain. Based on novel mouse models of recurrence of pain, we propose a critical role of IL-10 signaling in the maintenance of remission. Findings from the present proposal not only are essential to fill a major gap in knowledge of pain research regarding the mechanisms underlying the remission and relapse of pain but also important to the development of therapeutics to prevent relapse and the transition to chronic pain.

PI_NAMEs: LAUMET, GEOFFROY O (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Affect;Analgesics;Animals;Anti-Inflammatory Agents;Antibodies;Biochemistry;Calcium;Cells;Characteristics;chemotherapy;chronic pain;chronic pain patient;clinical practice;Cytokine Receptors;Data;delta opioid receptor;Disease remission;dorsal horn;Dose;Down-Regulation;endogenous opioids;Equilibrium;Event;Exhibits;experience;FDA approved;Flow Cytometry;Fostering;Gene Expression;Gene Expression Regulation;Genes;genetic signature;Goals;Image;Immune;Immunoassay;Individual;innovation;insight;Interleukin-10;interleukin-10 receptor;Interleukins;Intervention;Knowledge;magnetic beads;Maintenance;Mediating;Modeling;mouse model;Neuroimmune;neuroinflammation;Neuronal Plasticity;new therapeutic target;Nociception;novel;novel therapeutic intervention;Opioid;Opioid agonist;Opioid Receptor;Pain;pain chronification;Pain management;pain model;Pain Research;pain sensitivity;painful neuropathy;patch clamp;Patients;Persistent pain;pharmacologic;Population;Postoperative Period;prevent;public health relevance;Receptor Signaling;Recovery;Recurrence;Recurrent pain;Regulation;Relapse;relapse prevention;Research;Role;Signal Pathway;Signal Transduction;Source;Spinal;Spinal Cord;Spinal Ganglia;spontaneous pain;Surgical incisions;System;Testing;therapeutic development;Thinking;transcriptome sequencing;Transgenic Mice;Up-Regulation

PROJECT_TITLE: Neuroimmune interactions regulating the balance between remission and relapse of pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


PI_NAMEs: VORUGANTI, VENKATA SAROJA  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Area;base;Behavior assessment;Bioinformatics;Biological;Biological Assay;Blood specimen;Cell Culture Techniques;Clinical assessments;Collection;computerized data processing;Consensus;Consultations;Core Facility;Data;Data Set;design;Development;Dietary Component;DNA;DNA methylation profiling;Documentation;Educational workshop;Energy harvesting;Ensure;Epidemiology;exome;experience;Experimental Designs;Faculty;flexibility;Funding;Future;Gene Expression Profiling;gene interaction;Genes;Genetic;Genomics;Genotype;Gnotobiotic;Goals;Grant;gut microbiome;gut microbiota;Heterogeneity;human model;Human Resources;Individual;individual variation;Information Dissemination;Infrastructure;Intervention;Investigation;Laboratories;Lead;Location;Measurement;member;Mentors;Metabolic;metabolomics;Metagenomics;Methodology;methylation pattern;Microbiology;microbiome;microbiome analysis;microbiota;mid-career faculty;Modeling;mouse genetics;mouse model;Nature;North Carolina;Nutrient;nutrition;nutrition related genetics;Nutritional;nutritional genomics;Nutritional Study;Obesity;Participant;Physiological;Population;Population Genetics;precision nutrition;Procedures;Production;Productivity;professor;protocol development;Protocols documentation;Publications;Quality Control;recruit;Reproducibility;Research;Research Design;Research Institute;Research Personnel;Resources;response;RNA;Role;saliva sample;sample collection;Sampling;Services;Shotguns;Signal Transduction;Source;Statistical Data Interpretation;stool sample;Sulfides;symposium;System;Therapeutic;tool;Training;transcriptome sequencing;Translations;Universities;Variant;whole genome;Work

PROJECT_TITLE: Precision Nutrition Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PI_NAMEs: HEDMAN, BRITT  (contact)

PROJECT_TERMS: absorption;Biological;biological systems;Biomedical Research;Clinic;Collaborations;Communities;Complex;Computer software;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;Dedications;design;Detection;detector;Education and Outreach;Educational workshop;Electronics;experience;Experimental Designs;experimental study;Fostering;future implementation;Generations;Goals;Hybrids;Image;imaging facilities;imaging program;improved;In Situ;Individual;innovation;innovative technologies;instrumentation;International;Investments;Length;Libraries;Ligand Binding;Light;Measurement;Medical Imaging;Methods;millisecond;Modification;Molecular Biology;multimodality;online resource;operation;Optics;outreach;outreach program;Peer Review;Performance;Phase;Process;Research;Resolution;Resources;Roentgen Rays;Sampling;Schedule;Schools;Science;Scientist;Services;Site;Source;spectroscopic imaging;Spectrum Analysis;structural biology;structural imaging;submicron;success;synchrotron radiation;Synchrotrons;System;Techniques;Technology;Temperature;theories;Time;tool;Training;Training Programs;United States;web portal;X ray spectroscopy


PI_NAMEs: WEISS, THOMAS MICHAEL (contact)

PROJECT_TERMS: absorption;Automation;base;Biomedical Research;Biophysics;Clinic;Communities;Complex;Computer software;Coupled;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;data analysis pipeline;Data Collection;data quality;Dedications;detector;Development;Devices;Education and Outreach;Educational workshop;Ensure;Equipment;experience;experimental study;Feedback;Fiber;flexibility;Funding;Generations;Goals;Hand;improved;Individual;innovation;instrumentation;Investments;Light;Lipids;Logistics;Methods;Microfluidics;millisecond;Molecular Biology;Molecular Sieve Chromatography;Neutrons;online resource;operation;outreach;outreach program;Peer Review;Performance;Process;Proteins;Protocols documentation;Research;Resolution;Resources;Roentgen Rays;Sampling;Schools;Science;Services;Site;software development;Source;spectroscopic imaging;Stretching;structural biology;success;synchrotron radiation;Synchrotrons;Techniques;Technology;technology platform;Time;Training;United States National Institutes of Health;user-friendly;web portal;Work

PROJECT_TITLE: A Synchrotron Radiation Structural Biology Resources


PI_NAMEs: SOLTIS, STEPHEN  (contact)

PROJECT_TERMS: absorption;base;Behavior;Biomedical Research;Clinic;Collaborations;Communities;Complex;Computer software;Cryoelectron Microscopy;Crystallography;Data;Dedications;detector;diversity and inclusion;Doctor of Philosophy;Education and Outreach;Educational workshop;Elements;experience;experimental study;Generations;Goals;Grant;Individual;innovation;Institution;instrumentation;International;Internships;Laboratories;Light;Modality;Molecular Biology;online resource;operation;Outcomes Research;Output;outreach;outreach program;Peer Review;Performance;Procedures;Process;Productivity;programs;Publications;recruit;Research;Resources;Roentgen Rays;safety practice;Schedule;Schools;Science;Services;Site;sound;Source;spectroscopic imaging;structural biology;success;support tools;synchrotron radiation;Synchrotrons;Techniques;Technology;technology platform;Training;undergraduate student;Underrepresented Populations;urban area;web portal;web-based tool;x-ray free-electron laser


PI_NAMEs: ZEISEL, STEVEN H (contact)

PROJECT_TERMS: Achievement;Area;Award;career;career development;Career Mobility;Chronic Disease;Critiques;Data;diversity and inclusion;ethnic minority population;Faculty;Financial Support;Funding;Goals;Grant;Historically Black Colleges and Universities;Individual;innovation;interdisciplinary collaboration;Investments;member;Mentors;Minority Groups;minority investigator;North Carolina;nutrition;Obesity;programs;Publications;racial minority;racial minority population;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;role model;Scientist;success;Underrepresented Minority;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: COLUMBIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative B-cell-intrinsic MHCII signaling is fundamental to the process of clonal selection during germinal center (GC) reactions, and it is widely assumed that this serves as a diversifying force of selection on mature Ig repertoires. However, this assumption has not been adequately addressed, and has never been considered from the perspective of its potential significance in maintaining benign interactions between hosts and their resident gut flora. Collectively, the experiments proposed here represent the first comprehensive analysis of this assumption, will determine whether this process drives diversification of the gut microbial community in an IgA-dependent manner, and will determine whether MHCII promotes health by enhancing systemic humoral immune responses that restrict bacterial dissemination from the gut.

PI_NAMEs: KUBINAK, JASON L (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Ablation;Address;Adoptive Transfer;Affinity;Antibodies;Antibody Affinity;Antibody Response;antigen binding;Antigen Presentation;Automobile Driving;B-Lymphocytes;Benign;Bone Marrow;CD4 Positive T Lymphocytes;Cell Communication;Cell Compartmentation;Chimera organism;Chronic;Clone Cells;commensal bacteria;congenic;Congenic Mice;Data;Defect;density;Dependence;dysbiosis;Ecology;Evolution;Exons;experimental study;Extravasation;fitness;Generations;Genetic Polymorphism;Genetic Variation;Genotype;Germ-Free;Gut associated lymphoid tissue;gut microbiota;Health;Health Promotion;Heterozygote;Histocompatibility;Histocompatibility Antigens Class II;host microbiota;Human;IgA Deficiency;IL7R gene;immune activation;Immune response;Immune system;Immunoglobulin A;Immunologic Memory;Individuality;Inflammation;innovation;Integration Host Factors;Knowledge;Link;Lymphocyte;Mediating;Memory;MHC Class II Genes;microbial colonization;microbial community;microbiota;microbiota composition;microorganism antigen;Modeling;mouse model;Mucous Membrane;novel;Pathologic;Peyer's Patches;Phenotype;Physiology;Plasma Cells;Play;Population;Process;Promoter Regions;Reaction;response;Role;Shapes;Signal Transduction;Single Nucleotide Polymorphism Map;Structure of germinal center of lymph node;Surface;systemic inflammatory response;T-Cell Development;T-Lymphocyte;Testing;Tissues;Vertebrates;Visual;Work

PROJECT_TITLE: B-cell-intrinsic MHCII Signaling is a Diversifying Force of Selection on IgA Repertoires and the Gut Microbiota

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


PI_NAMEs: CARROLL, IAN MICHAEL (contact)

PROJECT_TERMS: Attention;Awareness;Basic Science;career;Clinical;Collaborations;Communities;community engagement;Dedications;design;Development;digital platform;doctoral student;Education;Educational Curriculum;Educational workshop;epidemiology study;Event;Faculty;Fostering;General Population;Goals;Health Professional;interdisciplinary collaboration;Intervention Studies;Knowledge;learning materials;lectures;Medical Students;Medicine;meetings;member;Methods;Minority Groups;minority investigator;Mission;next generation;North Carolina;nutrition;nutrition education;nutrition related genetics;nutritional genomics;Nutritional Science;Nutritional Study;Obesity;Online Systems;Physicians;Planet Earth;Policies;precision nutrition;professor;programs;Research;Research Institute;Research Personnel;Series;Students;symposium;Technology;Training;training opportunity;Training Programs;Translational Research;Travel;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Enrichment Program


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This proposal describes a renewal program from the Programs in Neuroscience and Pharmacology at Weill Cornell Medicine for the support of 4 pre-doctoral students in the study of the impact of genetic and environmental factors on drug addiction. The strengths of the program include the experience of the faculty in drug abuse research, mentoring and training as well as co-curricular programming themed around drug addiction and career and professional development.

PI_NAMEs: MILNER, TERESA A (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Genetic

PROJECT_TITLE: Genetic and Environmental Influences on Addiction


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE: Center Overview  Research addressing diabetes, related conditions, and their complications is relevant to public health because these disorders cause enormous suffering and death in addition to burdening the American health care system with the highest health and economic costs among chronic diseases. Through sophisticated Biomedical Research Core services, innovative Pilot and Feasibility projects, and engaging Enrichment activities, the Washington University Diabetes Research Center (DRC) conducts research that is an important component of efforts to treat, cure, and prevent diabetes and related endocrine and metabolic disorders.

PI_NAMEs: SEMENKOVICH, CLAY F. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;American;Animal Model;Area;Awareness;base;Biological;Biology;Biomedical Research;Blindness;career;Career Choice;Caring;cellular imaging;Cessation of life;Chronic Disease;CLIA certified;Clinical;Consultations;Creativeness;Dementia;Development;Diabetes Mellitus;diabetes risk;Direct Costs;Disease;economic cost;Education;education research;Endocrine System Diseases;Environment;Epidemiology;experimental study;Focus Groups;Fostering;Funding;Goals;Health;Health Care Costs;Healthcare Systems;Heart Diseases;Human;human disease;Immunology;improved;Infection;innovation;insight;Institution;Interdisciplinary Study;interest;invention;Investments;islet;Kentucky;Kidney Failure;Liquid substance;Malignant Neoplasms;Mass Spectrum Analysis;medical schools;Medical Students;member;Mentors;Metabolic;Metabolic Diseases;metabolic phenotype;metabolomics;Modeling;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;novel therapeutics;Participant;Patients;Persons;Phenotype;Population;Positioning Attribute;prevent;Prevention;Process;programs;Public Health;Regulation;Research;Research Personnel;Scientist;Services;skills;Stroke;Structure;Thinking;Tissue imaging;Tissues;Training;Training and Education;Translating;translational diagnostics;translational pipeline;Translational Research;Translations;Universities;Utah;Washington;Wisconsin;Work

PROJECT_TITLE: Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TITLE: Admin Core


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Myeloproliferative neoplasm (MPN) is a hematologic malignancy driven by a somatically acquired mutation most commonly in JAK2 (JAK2V617F), which currently lacks effective therapies for early stage patients, thus necessitating the development of novel treatment modalities. Preliminary clinical and experimental work has identified inflammation as an important factor that influences the relative growth rate of mutant cells, and preliminary collaborative mathematical modeling work indicates that this can potentially have a variety of consequences for the evolution of mutant cells at homeostasis. Novel computational methods, in combination with experimentation, are used to identify mechanisms of JAK2V617F mutant selection, to predict the evolutionary trajectories of JAK2V617F mutant cells under various inflammatory conditions, and to identify and test therapeutic targets to steer cellular evolution away from disease.

PI_NAMEs: FLEISCHMAN, ANGELA GOFFREDO (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Acute;Acute Myelocytic Leukemia;alternative treatment;Aspirin;Benign;Biological Assay;Biological Models;Blood coagulation;Cell Lineage;cell type;Cells;Chronic;Clinical;Clinical Trials;Collaborations;Complex;Computing Methodologies;Cues;Data;design;Development;Disease;Disease Progression;Dose;drug discovery;Early treatment;effective therapy;Evolution;experimental study;Future;Goals;Growth;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Homeostasis;improved outcome;in silico;in vivo;Inflammation;Inflammatory;inhibitor;Intervention;JAK2 gene;Kinetics;Laboratories;mathematical model;Mathematics;Measures;Mediating;Modality;Modeling;mouse model;Mus;mutant;Mutation;Myelofibrosis;Myelogenous;Myeloproliferative disease;new therapeutic target;novel;novel therapeutics;Outcome;Patients;Pharmaceutical Preparations;Population;predictive modeling;pressure;Process;Production;Publishing;Research;response;Risk;Risk Reduction;Sampling;Schedule;Stimulus;Survival Rate;symptom management;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Translating;Treatment Protocols;treatment strategy;Work

PROJECT_TITLE: Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


PI_NAMEs: FITZPATRICK, JAMES ALEXANDER (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Animals;Area;Basic Science;Behavior;Biological Assay;biological research;Cell Physiology;Cells;cellular imaging;Charge;Cilia;Consultations;Contrast Media;cost;Cryoelectron Microscopy;Custom;data acquisition;Data Analyses;Data Set;Dedications;Development;Diabetes Mellitus;Dimensions;Education;Educational workshop;Electron Microscopy;Electrons;Ensure;Equipment;Experimental Designs;Faculty;Feedback;Fluorescence;Funding;Generations;Goals;Grant;Heart;Human Resources;Image;Image Analysis;imaging facilities;Imaging Techniques;Imaging technology;Immunohistochemistry;improved;Individual;Informatics;innovation;Institution;instrumentation;Investments;Ions;islet;Laboratories;Laboratory Research;Learning;Light;light microscopy;live cell imaging;Liver;Macromolecular Complexes;member;Metabolic Diseases;Methodology;Micro Electron Diffraction;Microscope;Microscopic;microscopic imaging;Microscopy;molecular imaging;Morphology;new technology;operation;Optics;Pathogenesis;Physiological;Play;polypeptide;Preparation;Process;professor;programs;Property;Proteins;Publications;quantitative imaging;Research;Research Personnel;research study;Resolution;response;Roentgen Rays;Role;Sampling;Schedule;Scholarship;Services;single molecule;small molecule;Specialist;Specimen;Speed;Structure;superresolution imaging;superresolution microscopy;System;Technical Expertise;Techniques;Technology;technology platform;Time;tissue fixing;Tissue imaging;Tissues;tool;Training;Translational Research;translational study;treatment strategy;two-dimensional;two-photon;Universities;Visualization;Washington;Work;X ray microscopy

PROJECT_TITLE: Cell and Tissue Imaging


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Congenital Structural Anomalies;Genetics;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative ADAR1 is an RNA editing enzyme, mutation of which causes Aicardi-Goutieres Syndrome in humans. We have developed novel mouse models to study the mechanisms of disease and the relationship between RNA editing and innate immunity.

PI_NAMEs: STETSON, DANIEL B (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acute;ADAR1;Address;Adenosine;Alleles;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;Biology;cell type;Cells;CRISPR screen;Deamination;Disease;disease mechanisms study;Double-Stranded RNA;Enzymes;Epitopes;Genes;genome-wide;Host Defense;Human;human disease;IFIH1;Impairment;in vivo;insight;Interferon Type I;Interferon-beta;Interferons;Knock-in;Knock-in Mouse;Ligands;mortality;mouse model;Mus;mutant;Mutation;Natural Immunity;novel;nucleic acid detection;Nucleic Acids;Pathogenesis;Pathology;Pathway interactions;Patients;postnatal;prevent;Process;Production;pseudotoxoplasmosis syndrome;Regulation;Reporter;Resolution;response;RNA;RNA Editing;Role;sensor;Series;Signal Pathway;System;Therapeutic;tool;Viral;Work

PROJECT_TITLE: Intracellular nucleic acid detection in autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative This proposal aims to elucidate the virulence mechanism of F. tularensis, a bioterroist threat, by providing novel therapeutic targets to treat this dangerous bacterial pathogen.

PI_NAMEs: BRENNAN, RICHARD GERALD;DOVE, SIMON L;LEE, RICHARD E.;SCHUMACHER, MARIA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: aerosolized;Affinity;Automobile Driving;Bacteria;Binding;Biochemical;Biological Assay;bioweapon;Blood capillaries;C-terminal;Categories;Cells;Classification;Complex;Cryoelectron Microscopy;Dangerousness;Data;Development;Disease Outbreaks;Dissection;DNA;DNA Binding;DNA Structure;DNA-Binding Proteins;Drug Design;Drug Targeting;Elements;Fluorescence Polarization;Francisella;Francisella tularensis;Gene Expression;Genes;Goals;Government;Growth;Guanosine Tetraphosphate;Helix-Turn-Helix Motifs;Heterodimerization;Holoenzymes;improved;in vivo;inhibitor;Ligands;Macrophage;Mediating;Medical center;Molecular;Morbidity - disease rate;mortality;new therapeutic target;novel;novel therapeutics;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathogenicity Island;Peptides;Polymerase;prevent;promoter;protein expression;Proteins;Radial;rational design;recruit;Regulation;Regulator Genes;Regulon;Research;Resolution;Signal Transduction;Site;Starvation;Structure;Tail;Testing;Therapeutic;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Tularemia;Virulence;virulence gene;Winged Helix

PROJECT_TITLE: Molecular elucidation of the Francisella tularensis virulence mechanism

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Biotechnology;Immunotherapy

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The immunological synapse formed between antigen presenting cells and T cells is a complex network of hundreds of protein ligand-receptor interactions that modulate the strength, course and duration of an immune response. This proposal aims at developing novel computational techniques to identify cognate binding sites, and binding partners within the superfamily of cell surface anchored Immunoglobulin proteins and to experimentally verify these predictions. The new insights gained will be leveraged in combination with high throughput experimental protein engineering technique to redesign receptor interfaces for specificity, to develop new reagents to further interrogate the function of the immune synapse and to obtain biologic drug leads for immunotherapy.

PI_NAMEs: FISER, ANDRAS  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: adaptive immunity;Affinity;Antigen-Presenting Cells;Autoimmune Diseases;Binding;Binding Sites;Biochemical;Biological;Cell surface;Cells;Complex;Computational Technique;design;Disease;Engineering;experimental study;extracellular;follow-up;Goals;Human;immune function;Immune response;Immunoglobulins;immunological synapse;immunoregulation;Immunotherapy;In Vitro;insight;interdisciplinary approach;knowledgebase;Libraries;Ligands;Malignant Neoplasms;Maps;Molecular;mutant;Natural Immunity;novel;novel therapeutics;Phage Display;Pharmaceutical Preparations;pharmacophore;Protein Engineering;Proteins;Proteome;Reagent;receptor;Regulation;Specificity;synaptic function;T-Lymphocyte;Techniques;Therapeutic;Validation

PROJECT_TITLE: Molecular basis of recognition in the Immunological Synapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE During neonatal obstructive cholestasis, bile acids accumulate in the liver and blood through both impaired clearance and impaired suppression of synthesis. Our research will use a translational model of preterm piglets with bile duct ligation to examine the time-dependent adaptation of the liver to bile acid signaling, as well as, the contribution of classical and alternative bile acid synthesis pathways to determine which molecular targets are impaired. This research has important clinical relevance for the identification of pathways that may be targeted by pharmaceuticals to reduce liver injury that occurs during neonatal obstructive cholestasis from bile acids.

PI_NAMEs: GUTHRIE, GREGORY  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: absorption;Affinity;Agonist;analysis pipeline;Bile Acid Biosynthesis Pathway;Bile Acids;bile duct;Bile fluid;Biliary Atresia;Binding;Birth;Blood;career;career development;cell type;Cells;Child Nutrition;Childhood;cholangiocyte;Cholestasis;Cholesterol 7-alpha-Monooxygenase;Clinical;clinically relevant;college;Compensation;CYP7A1 gene;Digestive System Disorders;Disease;Doctor of Philosophy;Dose;Enteral;Environment;Enzymes;Extrahepatic Bile Ducts;Faculty;Family suidae;Feedback;fexaramine;FGF19 gene;Fibroblast Growth Factor Receptors;Future;Gene Expression Profile;Goals;Growth;Hepatic;Hepatobiliary;hepatocellular injury;Hepatocyte;Homeostasis;Hormones;Human;ileum;Impairment;Infant;Inflammation;Infusion procedures;Injury;Intestines;kinetic model;Knowledge;laser capture microdissection;Life;Ligation;Liver;Liver diseases;liver injury;liver transplantation;Mass Spectrum Analysis;Mediating;Medicine;Mentorship;Mitochondria;Modeling;Molecular;Molecular Target;National Institute of Diabetes and Digestive and Kidney Diseases;Neonatal;neonate;Nuclear Hormone Receptors;Nutritional Study;Organoids;Oxidative Stress;Pathology;Pathway interactions;Pharmacologic Substance;Physiological;Population;porcine model;Procedures;Proteins;receptor;Receptor Activation;Receptor Cell;Receptor Signaling;Regulation;Reporting;Research;Research Personnel;Serum;sham surgery;Signal Pathway;Signal Transduction;Site;skills;Source;stable isotope;success;Testing;Therapeutic Intervention;Time;Training;transcriptome sequencing;transcriptomics;translational model;Visualization

PROJECT_TITLE: Regulation of Hepatobiliary Bile Acid Homeostasis in Neonatal Obstructive Cholestasis

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Diabetes;Nutrition

PI_NAMEs: LODHI, IRFAN J (contact)

PROJECT_TERMS: Affect;Animal Model;Animals;Biochemical;Biological Assay;Blood pressure determination;Body Composition;Cell Culture Techniques;Cells;Cholesterol;Clinical;clinical application;Communities;Consultations;cost effective;cost effectiveness;Data;Diabetes Mellitus;diabetic;Disease;Dual-Energy X-Ray Absorptiometry;Energy Metabolism;Environment;experience;Experimental Designs;experimental study;Feedback;Funding;Glucose;Glucose Clamp;glucose tolerance;Goals;Human;Hyperinsulinism;improved;In Vitro;Indirect Calorimetry;innovation;insight;instrumentation;Insulin Resistance;Laboratories;Measures;meetings;member;Metabolic;Metabolic Diseases;Metabolism;Methodology;Modeling;Modification;Molecular;mouse model;Mus;Nonesterified Fatty Acids;novel;Obesity;Organ;Organism;Paper;Patient Care;Phenotype;Productivity;Publications;Reproducibility;Research;Research Personnel;Research Project Grants;response;Sampling;Scanning;Scientist;Serum;service utilization;Services;Surveys;Systemic disease;Technology;Testing;Time;Tissues;Training;Translating;translational potential;Triglycerides;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Diabetes Models Phenotyping


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric;Prevention

PHR: There is a paramount need for pediatricians who are skilled in modern scientific methods and have the background to develop novel approaches to the diagnosis, treatment, and prevention of childhood diseases. The proposed career development program will foster the maturation of talented pediatric early-career faculty into independent investigators who use cutting-edge methods of laboratory and clinical research and who pursue long-term academic careers investigating important issues related to childhood diseases.

PI_NAMEs: LINARDIC, CORINNE MARY;REED, ANN M. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Academic Medical Centers;Area;Basic Science;career;career development;Child Health;Childhood;Clinical Research;Clinical Sciences;Communities;Computational Biology;Core Facility;Dedications;Development;didactic education;Doctor of Philosophy;Duke Comprehensive Cancer Center;Educational Curriculum;Emerging Technologies;Engineering;Ensure;Environment;Evaluation;experience;Faculty;Fostering;Funding;Genomics;Grant;Individual;Infection;Inflammation;innovation;Joints;K-Series Research Career Programs;Laboratory Research;Medicine;Mentors;Methods;Molecular;National Cancer Institute;operation;Outcome;pediatric department;peer coaching;Physicians;Physiology;Principal Investigator;Process;programs;Recording of previous events;recruit;Research;research facility;Research Institute;Research Methodology;Research Personnel;Research Support;Resource Development;Schools;Science;Scientist;skills;Structure;Training;Translational Research;Underrepresented Populations;Universities;Woman;Writing

PROJECT_TITLE: Duke Center for Advancement of Child Health (CAtCH)


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The Harvard Digestive Disease Center (HDDC) is a community of scientists focused on the study of epithelial cell function and mucosal biology including inflammation and host defense of the gastrointestinal tract. The Center facilitates research in these fields by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among our members. We have a major commitment to training, mentoring and supporting young scientists in digestive disease research and to fostering the early careers of new faculty.

PI_NAMEs: LENCER, WAYNE I (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Address;Adult;Affinity;Area;Award;base;Basic Science;biobank;Biological;Biology;Biometry;Boston;career;Cell Physiology;cell type;Cells;Cellular biology;Childhood;Clinical;clinical center;Clinical Investigator;clinical practice;Clinical Research;Clinical Sciences;Collaborations;Colonic Diseases;Communities;Complex;Curiosities;Development;Developmental Biology;Digestive System Disorders;Disease;Doctor of Philosophy;Ecosystem;Educational workshop;Epithelial Cells;Epithelium;Equipment;Faculty;Faculty Recruitment;falls;Fellowship Program;Fostering;frontier;Funding;Future;Gastroenterology;Gastrointestinal tract structure;Gnotobiotic;Grant;gut microbiome;Health;Histopathology;Hospitals;Host Defense;Human;Immune;Immunology;Individual;Inflammation;Inflammatory;Infrastructure;Institution;Interdisciplinary Study;Intestinal Diseases;Investments;Laboratories;Leadership;Medical;medical schools;meetings;member;Mentors;Mesenchymal;Metabolic;Metabolism;microbial;Microbiology;Microscopy;Mission;Molecular Biology;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Neurons;new technology;Organ;Paper;Pathogenesis;Persons;Physicians;Physiology;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Research;Research Personnel;Resolution;Resources;Science;Scientist;Services;stem cell biology;Stomach Diseases;Surface;symposium;Talents;Teaching Hospitals;Technical Expertise;Technology;Tissues;Training;Training Programs;Translational Research;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Integrated Epithelial and Muscosal Biology


NIH_SPENDING_CATS: Digestive Diseases

PROJECT_TERMS: Abbreviations;Acceleration;Advisory Committees;Basic Science;Biology;Boston;Clinical Investigator;clinical practice;clinical translation;Collaborations;Communication;Communities;Core Facility;Dana-Farber Cancer Institute;Dental;Development;Diabetes Mellitus;Digestive System Disorders;Discipline;Disease;Electronic Mail;Epithelium;Equipment;Fostering;Funding;Gastrointestinal tract structure;Goals;Grant;Health;Hospitals;Human;Institution;interest;Israel;Lead;Leadership;Maintenance;Medical center;medical schools;member;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Pediatric Hospitals;Persons;programs;Public Health Schools;recruit;Reporting;Research;Research Personnel;Resources;Scientist;Services;Technical Expertise;Training;Translational Research;translational research program;Translations;United States National Institutes of Health;Universities;web site;Woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Interactions between different biomolecules, including proteins, lipids and metabolites, give rise to higher cellular, tissue and organismal functions. Perturbation of these interaction are observed during aging and in disease and can help identify disease mechanisms. We propose to develop an analytical multi-omics pipeline to identify functional relationships between different biomolecules and determine mechanisms contributing to brain aging and neurodegenerative diseases.

PI_NAMEs: CUMMINGS, MICHAEL P;KANE, MAUREEN A;LIPINSKI, MARTA M (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Affect;age related;age related neurodegeneration;age-related disease;Aging;aging brain;Alzheimer's disease related dementia;Bioinformatics;Biological Assay;Brain;brain dysfunction;cell type;Classification;Complex;computerized data processing;Coupled;CRISPR/Cas technology;Data;Deposition;Development;Disease;Gene Expression Profile;Individual;interest;Intervention;Investigation;Late Onset Alzheimer Disease;life span;lipid metabolism;lipidome;lipidomics;Lipids;Lysosomes;Machine Learning;Mass Spectrum Analysis;member;Metabolic Pathway;metabolomics;Methodology;Methods;Microglia;Mitochondria;mouse model;multiple omics;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Organelles;Pathway interactions;Phenotype;Process;Proteins;Proteome;Proteomics;Publications;Pythons;Reporter Genes;repository;Research Infrastructure;Research Personnel;response;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Software Tools;Source Code;Testing;The Jackson Laboratory;Tissues;tool;Transgenic Mice;Transgenic Organisms;usability

PROJECT_TITLE: Cell-type and organelle-specific multi-omics platform for the study of brain aging


NIH_SPENDING_CATS: Diabetes;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: URANO, FUMIHIKO  (contact)

PROJECT_TERMS: American;Biological Assay;Cells;Communities;Consultations;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;Endocrine System Diseases;Equipment;Etiology;Functional disorder;Funding;Generations;Health;Hormone secretion;Human;improved;induced pluripotent stem cell;Insulin deficiency;islet;Islets of Langerhans;Laboratories;member;Metabolic;Metabolic Diseases;metabolic rate;Metabolism;Names;novel therapeutics;Paper;Pathogenesis;Prediabetes syndrome;prevent;Publications;Research;Research Design;Research Personnel;Resources;response;Rodent;Service provision;Services;Tissues;Universities;Washington

PROJECT_TITLE: Metabolic Tissue Function


NIH_SPENDING_CATS: Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: PROJECT NARRATIVE Patients who self-identify as Black have a disproportionately high risk of developing kidney disease, and this health difference is partially driven by naturally occurring DNA variants in the APOL1 gene that are specific to individuals of African ancestry. Our goal is to investigate how these APOL1 variants, which evolved in the context of the immune response, alter the function of immune cells such as macrophages. New scientific information produced by our proposed work will offer novel insights for how macrophages contribute to APOL1-related kidney disease, identifying an additional cell type to consider in disease pathogenesis and therapeutic strategies.

PI_NAMEs: LIN, JENNIE J (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Address;Affect;African ancestry;African Trypanosomiasis;Alleles;American;Anti-Inflammatory Agents;Apolipoproteins;Apoptotic;Attenuated;attenuation;Automobile Driving;biological adaptation to stress;Biological Factors;Biological Models;Biology;Black race;cell type;Cells;Cholesterol Homeostasis;Chronic;Chronic Kidney Failure;Coculture Techniques;Code;comorbidity;Complex;Cytokine Signaling;Development;Disease;disease phenotype;Disease Progression;DNA;End stage renal failure;Endoplasmic Reticulum;endoplasmic reticulum stress;experience;Functional disorder;Genes;Genetic study;Genetic Transcription;genome editing;genomic locus;Genotype;Goals;Health Care Costs;health difference;high risk;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;Immune;immune function;Immune response;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;Injury;Injury to Kidney;Innate Immune Response;insight;Interferon Type II;Interleukin-10;Interleukin-4;Investigation;Kidney;kidney cell;Kidney Diseases;kidney fibrosis;kidney repair;Link;lipid metabolism;Macrophage;Measures;Mediating;metabolic abnormality assessment;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular Chaperones;mortality;Natural Immunity;novel;pathogen;Pathogenesis;Pathway interactions;Patients;Phagocytes;Phenotype;Play;podocyte;Primates;Process;protein activation;protein function;Proteins;Quality of life;Reactive Oxygen Species;Resolution;Respiration;response;response to injury;Risk;Risk Factors;risk variant;Role;Signal Transduction;Signaling Protein;socioeconomics;Sterility;Stimulus;Stress;Testing;Therapeutic;tissue repair;Tissues;transcriptomics;Transgenic Mice;United States;Validation;Variant;Work

PROJECT_TITLE: Macrophages and attenuation of inflammation resolution in APOL1 nephropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(03)]