PHR: Project narrative Long-range cell-to-cell communication is vital to all multicellular organisms during development and in maintaining homeostasis. Recent discoveries suggest that cells can communicate precisely and reliably via long, thin cellular protrusions. Our research has revealed such a process in zebrafish development that also requires the involvement of macrophages as signaling intermediaries. Studies proposed here will reveal underlying molecular mechanisms of cellular protrusion-mediated signaling and interrogate whether such signaling is generally utilized in other cell types.

PI_NAMEs: EOM, DAE SEOK  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Cell Communication;cell type;Cells;Cessation of life;Communication;Communications Media;Development;Developmental Biology;Diameter;Diffuse;Diffusion;Disease;Epidermis;Evolution;extracellular;Filopodia;Foundations;Functional disorder;Homeostasis;Human;in vivo;intercellular communication;keratinocyte;Ligands;Link;Macrophage;Malignant Neoplasms;Mediating;Mediation;Modeling;Molecular;Names;notch protein;novel;Organism;Paracrine Communication;Pathology;Pattern Formation;Pigments;Process;receptor;Research;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;Specificity;Thinness;Tissues;transmission process;Vertebrates;Vesicle;Zebrafish;zebrafish development

PROJECT_TITLE: Signaling at a distance mediated by vesicles on novel cellular protrusions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This interdisciplinary training program is designed to provide the necessary resources, infrastructure, and research opportunities for predoctoral and postdoctoral trainees interested in toxicology and environmental health effects on human diseases. The goal of the Curriculum in Toxicology and Environmental Medicine at UNC-CH is to train new scientists that are able to enhance our understanding of how the environment affects human disease.

PI_NAMEs: REBULI, MEGHAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Pre- and Postdoctoral Training in Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Understanding the structure and function of auditory cortex is critical for a complete understanding of the human auditory system, yet a consistent and accurate approach to parcellating even the primary auditory region A1 has not been established. This project takes a state-of-the-art, multimodal approach to characterizing A1, by combining ultra-high-field (7T) magnetic resonance imaging (MRI) anatomical data at an unprecedented resolution (0.35 mm3) with task-based and resting-state functional measures of auditory cortical processing. This comprehensive research will expand our understanding of auditory cortical processing in normal-hearing individuals, aid in the standardization of auditory cortex characterizations in future studies, and help inform the development of effective treatment options for various auditory processing deficits, such as those rooted in central auditory processing.

PI_NAMEs: ALLEN, EMILY J (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Access to Information;Acoustics;Address;anatomic imaging;Anatomy;Architecture;Area;area striata;Atlases;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;Biological;Biological Markers;Cognition;Cognitive;common treatment;Communities;Complement;Complex;Computer Models;Consensus;Data;deafness;Development;effective therapy;Exhibits;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;hearing impairment;Hearing problem;Human;in vivo;Individual;Inherited;insight;Location;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;multimodality;Music;Nature;neuroimaging;Neurosciences;normal hearing;novel;Pattern;Peripheral;Population;Positioning Attribute;Property;Research;Resolution;response;Rest;Role;Shapes;sound;Speech;Standardization;Structure;success;System;Techniques;Work

PROJECT_TITLE: Functional and structural characterization of human auditory cortex using high resolution MRI

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  In the proposed research we will examine the mechanisms by which memantine, one of the few drugs approved for treatment of Alzheimer's disease, protects nerve cells from damage. We will study how memantine works physiologically, use computer modeling and medicinal chemistry to design and synthesize new neuroprotective drugs, and use the new drugs to deepen understanding of neuroprotective strategies. The proposed research will examine a new approach for developing therapeutic drugs and will produce lead compounds for future development of improved medications to treat Alzheimer's disease.

PI_NAMEs: JOHNSON, JON W. (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acetylcholinesterase;Acetylcholinesterase Inhibitors;Activities of Daily Living;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;antagonist;Area;Binding;Binding Sites;Biological Assay;Brain;cell injury;Cerebrovascular Disorders;channel blockers;Chemical Models;cholinergic neuron;chronic pain;Clinical;clinical efficacy;Clinical Trials;cognitive function;Communication;Compensation;Comprehension;Computer Models;Dementia with Lewy Bodies;Dependence;desensitization;design;Development;Disease;Docking;Drug Addiction;Drug Design;drug development;drug modification;effective therapy;Effectiveness;Epilepsy;Excitatory Synapse;excitotoxicity;Exhibits;experimental study;Exposure to;FDA approved;Functional disorder;Future;Glutamate Receptor;Goals;improved;in silico;inhibitor;innovation;Ketamine;Lead;Learning;Link;Mediating;Memantine;Memory;Methods;Modeling;molecular dynamics;Molecular Mechanisms of Action;Mutagenesis;mutant;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nerve Degeneration;nerve supply;Nervous System Disorder;Nervous System Physiology;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;Neuroprotective Agents;NMDA receptor A1;novel strategies;novel therapeutic intervention;novel therapeutics;Parkinson's Dementia;Pathologic;Pathology;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physiological;predictive modeling;Preparation;Probability;Process;programs;Property;rational design;receptor;Recombinants;Research;Role;Safety;side effect;Signal Transduction;simulation;Site-Directed Mutagenesis;Slice;Stroke;Synaptic plasticity;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Time;tool;Toxic effect;Traumatic Brain Injury;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular Dementia;Work

PROJECT_TITLE: Ca2+-Dependent Block by Mematine and Selective Inhibition of Overactive NMDA Receptors

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE There is a positive association between increasing cancer-related angiogenesis and worsening prognosis. We will develop a novel technique for the assessment of the architectural properties of angiogenic microvasculature using multiple scattering of ultrasound. Ultimately, the methods developed will be used for diagnosis and monitoring of cancer.

PI_NAMEs: MULLER, MARIE  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Acoustics;angiogenesis;Angiography;Anisotropy;Architecture;Artificial Implants;Atherosclerosis;Benchmarking;Benign;biomarker development;biomedical imaging;Biopsy;Blood Vessels;Breast;breast cancer diagnosis;Breast Magnetic Resonance Imaging;cancer biomarkers;cancer diagnosis;Cancer Model;Chronic;Clinical;contrast enhanced;Contrast Media;cost;Data;density;Deposition;Detection;Diagnosis;diagnostic value;Diffusion;Disease;elastography;Evaluation;follow-up;Frequencies;Gadolinium;Genetically Engineered Mouse;Histology;Human;human subject;Image;Imaging Techniques;Imaging technology;Immunofluorescence Immunologic;improved;in vivo;Kidney Failure;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Ultrasonography;Mammography;Measurement;Measures;mechanical properties;Methods;Microbubbles;Monitor;Morbidity - disease rate;Morphology;Neoplasms in Vascular Tissue;neovasculature;Network-based;new technology;novel;Nutrient;Oxygen;Patients;perfusion imaging;point of care;Population;Populations at Risk;Primary carcinoma of the liver cells;Prognosis;prognostic value;Property;psychosocial;quantitative ultrasound;Rattus;Research;Resolution;Rodent;Roentgen Rays;Rupture;Safety;screening;Screening procedure;Sensitivity and Specificity;Specificity;Structure;Techniques;Thinness;Time;tool;Travel;tumor;Tumor Angiogenesis;ultra high resolution;Ultrasonic Transducer;Ultrasonic wave;Ultrasonics;Ultrasonography;ultrasound;Vascularization;Woman;Women's mortality;X-Ray Computed Tomography;young woman

PROJECT_TITLE: Quantitative assessment of angiogenesis using ultrasound multiple scattering

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project narrative Stroke affects approximately 800,000 people in the United States annually and is the leading cause of long-term disability in the US. This project is working to discover mechanisms of inflammation and neuronal death in the brain following experimental stroke to identify new therapeutic targets.

PI_NAMEs: MEARES, GORDON P. (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;Area;Astrocytes;Attenuated;attenuation;biological adaptation to stress;Biology;Blood flow;blood-brain barrier permeabilization;Brain;Brain region;Cell Death;cell injury;Cell Survival;Cerebral Ischemia;Cerebrum;Cessation of life;CISH gene;cognitive ability;Complex;conditional knockout;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Eukaryotic Initiation Factors;functional outcomes;Future;Gene Expression;Genes;Genetic;Hour;Human;I Kappa B-Alpha;Impaired cognition;improved outcome;in vitro Model;in vivo;Induced Neurons;Infarction;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-6;Ischemia;ischemic injury;Ischemic Stroke;JAK1 gene;Janus kinase;Knock-out;Knockout Mice;Long term disability;Mediating;Microglia;Middle Cerebral Artery Occlusion;Motor;mouse model;Nerve Degeneration;nerve injury;neural model;Neuroglia;neuroinflammation;neuron loss;Neurons;neurotoxic;new therapeutic target;novel;Nutrient;Outcome;Oxygen;Pathway interactions;Persons;Phosphorylation;Phosphotransferases;preservation;Prevalence;prevent;Protein Inhibition;protein kinase R;Protein Tyrosine Kinase;Protein-Serine-Threonine Kinases;Proteins;Reporting;restoration;Rodent;Role;Severities;Signal Transduction;small molecule;stress kinase;Stroke;stroke model;stroke outcome;synergism;Testing;Therapeutic;therapeutic target;Tissues;TNF gene;transcription factor;Translational Repression;Translations;United States;Wallerian Degeneration;Work

PROJECT_TITLE: PERK dependent mechanisms of neuroinflammation

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narratives/Relevance  The EXPLORER total-body PET scanner has limitations due to its poor timing resolution and lack of DOI-encoding, both of which offset its effective sensitivity gain, specially for imaging single organs, despite the very costly improvement of its geometric coverage. In the proposed work we will develop cost-effective and practical single-ended TOF-DOI-Compton PET detector modules, where these capabilities are enabled by using our novel right an-gle prism mirror light guides which enhance (1) light sharing by efficient 180-degree bending of photon paths and (2) crystal identification by localiz-ing the shared photons to only those immediate neighboring pixels that help with the correct identification. Our Prism-PET scanner with < 120 ps timing resolution, 1.85 mm DOI-encoding, and 88% Compton-scatter recovery miti-gates the limitations with the EXPLORER total-body scanner and achieves unparalleled spatial resolution and sensitivity.

PI_NAMEs: GOLDAN, AMIRHOSSEIN  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Prism-PET: A TOF-DOI-Compton PET detector technology for total-body PET imaging


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Violence Research

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The serotonergic (5-HT) and dopaminergic neuromodulatory systems have both been implicated in aggression, yet the specific cell types and circuitry involved remain unknown. This project will study a dopamine (DA)- responsive serotonergic neuron subtype involved in the modulation of aggression and acoustic startle reactivity in mice and will inform on the functional interplay between 5-HT and DA in the modulation of behavior. Understanding the circuit structure of this 5-HT neuron subtype may inform better therapeutics for the treatment of escalated aggression and/or altered startle reactivity, which can occur in neuropsychiatric disorders such as intermittent explosive disorder, schizophrenia, autism, and post-traumatic stress disorder.

PI_NAMEs: LYON, KRISTINE ANNE (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Accounting;Acoustics;Aggressive behavior;Animals;Area;aspirate;Attenuated;Auditory;autism spectrum disorder;awake;Award;Axon;Bacterial Artificial Chromosomes;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Biological Models;Bite;brain circuitry;BRAIN initiative;Brain region;Brain Stem;career;Cell Count;cell type;Cells;Complex;Data;Development;Doctor of Philosophy;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;DRD2 gene;experimental study;Fellowship;Female;Fiber;Future;Genetic;Goals;Head;Health;Human;In Situ;in vivo;Individual;interest;Intermittent Explosive Disorders;Knock-out;Knowledge;Label;Laboratory Finding;Learning Skill;Loudness;male;maternal aggression;Mentors;Molecular;Molecular Genetics;mouse model;Mus;nerve supply;Nervous System;Neurobiology;neuronal circuitry;neuronal excitability;Neurons;neuropsychiatric disorder;neuroregulation;Neurotransmitters;Noise;novel;offspring;Organism;Partner in relationship;Pathway interactions;Pattern;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;pre-doctoral;presynaptic;Prosencephalon;rabies viral tracing;receptor;Reporter;Research;Research Personnel;Research Project Grants;Resolution;Resources;Role;Schizophrenia;screening;screening panel;Serotonergic System;Serotonin;sex;Sex Differences;sexual dimorphism;Signal Transduction;skills;Social Behavior;Source;Startle Reaction;stem;Structure;Synapses;Synaptophysin;System;Techniques;Territoriality;Testing;Therapeutic;tool;Training;transcription factor;Transgenes;Violence;Viral;Viral Vector;virus genetics;women versus men;Work;Writing

PROJECT_TITLE: Circuits, Serotonergic Neurons, and the Modulation of Behavior: Characterization of a Specialized Serotonergic Neuron Subtype Responsive to Dopamine and Central to Social Behavior


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Rheumatoid arthritis is the most common autoimmune joint disease worldwide where fortunately over 15 treatments are available, however finding the most effective treatment for a patient remains a trial-and-error approach. This proposal is directly in line with NIAMS’ strategic plan to use machine learning to define personalized medicine profiles through the integration of electronic health records. In this study, we apply state-of-the-art approaches such as semi-supervised machine learning and inference modeling to maximize the data obtained from an RA clinical trial, RA registries, and EHR data towards more efficiently matching RA patients with treatments that will work for them.

PI_NAMEs: CAI, TIANXI ;LIAO, KATHERINE PHOENIX (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: arm;arthritis registry;arthritis therapy;arthropathies;Autoimmune;causal model;Clinical;Clinical assessments;Clinical Data;Clinical Management;Clinical Trials;compare effectiveness;Data;data integration;data registry;Data Set;Disease;effective therapy;Electronic Health Record;functional status;Genetic Crossing Over;Healthcare Systems;Hydroxychloroquine;improved;Inflammatory;inhibitor;innovation;Institution;Joints;Link;Machine Learning;machine learning method;Measurement;Methodology;Methods;Methotrexate;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;optimal treatments;Outcome;Participant;patient population;patient subsets;Patients;performance tests;personalized medicine;Physicians;Population;predicting response;Prediction of Response to Therapy;Randomized;Randomized Controlled Clinical Trials;Recommendation;recruit;Registries;Research Design;Resources;response;Rheumatoid Arthritis;rheumatologist;Sample Size;Site;Strategic Planning;Subgroup;Sulfasalazine;supervised learning;Testing;Therapy trial;TNF gene;treatment effect;Treatment Effectiveness;treatment response;treatment strategy;United States Department of Veterans Affairs;Work

PROJECT_TITLE: Bridging clinical trial and real-world data via machine learning to advance rheumatoid arthritis treatment strategies

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Poor postpartum health has implications for maternal mortality and infant outcomes. However, eligibility for pregnancy-related Medicaid ends after 60 days postpartum, leading to high rates of postpartum insurance loss. The proposed project evaluates how the Medicaid continuous coverage requirement during the public health emergency affected postpartum coverage, care, and infant care overall, by maternal race-ethnicity, and during various periods of the COVID-19 pandemic context, with implications for state postpartum Medicaid extensions under the American Rescue Plan.

PI_NAMEs: ELIASON, ERICA L (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Affect;American;Award;Birth;Black Populations;career;career development;Caring;Childbirth;Clinical;Contraceptive methods;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Databases;demographics;Department chair;Developed Countries;Development;Discipline of obstetrics;Disparity;disparity reduction;Eligibility Determination;Emergency Medicine;Epidemiology;ethnic disparity;Ethnic Origin;experience;Family;federal poverty level;Freezing;Future;Goals;Gynecology;Health;health care availability;health care disparity;health care service;health disparity;Health Insurance;health outcome disparity;Health Policy;Health Services;Health Services Accessibility;Healthcare;Healthcare promotion;Hispanic Populations;improved;Income;Individual;Infant;Infant Care;Infant Health;infant outcome;Insurance;interest;Link;Low income;Low Income Population;Maternal and Child Health;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Measures;Medicaid;Medicaid eligibility;Medicine;Mentors;Mentorship;Methods;National Institute of Child Health and Human Development;Outcome;pandemic disease;Pediatrics;people of color;Persons;Phase;Policies;poor health outcome;Population Study;postpartum care;Postpartum Depression;postpartum health;Postpartum Period;Pregnancy;Pregnancy loss;prevent;professor;public health emergency;Qualifying;Race;racial disparity;Research;Research Assistant;Research Personnel;Research Priority;Research Project Grants;response;Rhode Island;Risk;Severities;skills;Techniques;Testing;Time;Training;treatment effect;United States;Universities;Variant

PROJECT_TITLE: The Effects of the Medicaid Continuous Coverage Requirement during the Public Health Emergency on Postpartum Coverage and Maternal and Infant Care after Childbirth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative. Improper gene expression causes many diseases, including developmental defects and cancer. The goal of this project is to understand the fundamental processes by which genes are expressed and regulated. This understanding will be essential for designing treatments and drugs to restore normal gene expression in diseased cells or to alter gene expression patterns to create pluripotent stem cells and specific differentiated cell types.

PI_NAMEs: BURATOWSKI, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Address;Affect;Binding;Biological Assay;Biological Models;Bromodomain;Cell Differentiation process;cell type;Cells;Chromatin;Color;Complex;Defect;Development;Disease;Dissociation;DNA;DNA Binding;Enzymes;Eukaryota;experience;experimental study;Fluorescence Resonance Energy Transfer;Foundations;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Goals;Histone Acetylation;Histone H4;histone methylation;histone methyltransferase;histone modification;Histones;Human;Image;Immobilization;In Vitro;in vivo;insight;Kinetics;Knowledge;Label;Lead;Link;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;methylation pattern;Microscopy;Minor;Modeling;Molecular;Molecular Conformation;Monitor;Mutation;Nuclear Extract;Nucleosomes;Pathway interactions;Peptide Initiation Factors;Pharmaceutical Preparations;Physiological;Pluripotent Stem Cells;Process;Productivity;promoter;Promoter Regions;Protein Subunits;Proteins;Publishing;Reaction;RNA;RNA Polymerase II;Saccharomyces cerevisiae;single molecule;single-molecule FRET;Site;Statistical Data Interpretation;System;TAF1 gene;TATA Box;TATA-Binding Protein Associated Factors;TATA-Box Binding Protein;Techniques;Testing;therapy design;Time;time use;Total Internal Reflection Fluorescent;Transcription Elongation;transcription factor;Transcription Initiation;Work;Yeasts

PROJECT_TITLE: RNA polymerase II transcription initiation complex

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: NARRATIVE Gene expression changes that occur during postnatal development, and how these are regulated by genetic variation and through epigenetic mechanisms, remains largely unknown in humans. As the Laboratory, Data Analysis, and Coordinating Center for the Developmental Genotype-Tissue Expression Project, we will characterize multiple human tissues across developmental stages using single cell and spatial sequencing technologies to map spatiotemporal changes in gene expression across tissues and development. We will integrate these results with RNA sequencing data from ~3,600 tissue samples, from 120 postnatal post-mortem donors, to identify genetic regulatory effects that are specific to development.

PI_NAMEs: ARDLIE, KRISTIN  (contact);GETZ, GAD A

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: 21 year old;Adolescence;Adult;Affect;Age;Anatomy;ATAC-seq;Autopsy;biobank;Biological Assay;Biology;Brain;Cell model;cell type;Cells;Cellular Assay;Childhood;Collaborations;Communities;Compensation;Complex;Computational Biology;computerized tools;Computing Methodologies;Consent;cost;Data;Data Analyses;data integration;data management;data sharing;Development;Developmental Process;Disease;Disease susceptibility;Elements;Ensure;Epigenetic Process;epigenomics;Gene Expression;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genomic profiling;Genotype-Tissue Expression Project;Goals;Heart;Human;Human Cell Line;Human Development;human disease;Human Genetics;human tissue;Immune;Individual;innovation;interest;Investments;Laboratories;Link;Logistics;Lung;Maps;Masks;Measures;Mediation;meetings;Methods;model organism;Modeling;Molecular;Molecular Profiling;Multiomic Data;multiple omics;Nucleic Acid Regulatory Sequences;operation;postnatal;postnatal development;postnatal human;preservation;Process;Production;programs;Protocols documentation;Proxy;Quantitative Trait Loci;rare variant;Regulation;Regulatory Element;Research;Resolution;Resources;RNA;RNA Splicing;Sample Size;Sampling;scaffold;Science;single cell genomics;single cell technology;single nucleus RNA-sequencing;spatial relationship;spatiotemporal;Specificity;Structure;Technology;Time;Tissue Sample;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Work;XCL1 gene

PROJECT_TITLE: Developmental GTEx Laboratory, Data Analysis and Coordination Center


NIH_SPENDING_CATS: Cancer;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Polyomaviruses (PyVs) cause debilitating human diseases, including the often-fatal Merkel cell skin carcinoma. How these small DNA viruses transport to the nuclear membrane and then into the nucleus, where genome replication leads to infection and transformation, is not well understood. This innovative study aims to elucidate the nuclear entry mechanisms of two distinct PyVs and the role of host motor proteins in this process.

PI_NAMEs: SPRIGGS, CHELSEY CIERRA (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Advisory Committees;Award;Biochemical;Biology;Cancer Etiology;Cell Nucleus;Cells;Cellular biology;Crowding;Cytoplasm;Cytosol;Data;Disease;DNA Tumor Viruses;DNA Viruses;Dynein ATPase;Electron Microscopy;Endoplasmic Reticulum;Endosomes;Environment;event cycle;Family;GAG Gene;Genetic Transcription;Genome;Genomics;Human;human disease;human pathogen;Infection;innovation;Intracellular Transport;Kinesin;Knowledge;Learning;Left;Life Cycle Stages;light microscopy;Lytic Phase;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;Mentors;Merkel cell carcinoma;Merkel Cells;metaplastic cell transformation;Michigan;Microscopy;Microtubules;Mitosis;Mitotic;Motor;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore Complex;Pathway interactions;Penetration;Phase;Play;Polyomavirus;Polyomavirus Infections;Process;programs;protein transport;Proteins;Public Health;Reporting;Research;research facility;Resolution;Resource Development;Role;Route;Running;Simian virus 40;Skin Carcinoma;Techniques;therapeutic target;Time;Training;Universities;Viral;Viral Genome;virology;Virus;virus host interaction;Virus Replication

PROJECT_TITLE: Hijacking host cellular motors for the nuclear entry of polyomaviruses


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The neural mechanisms of regulation support socioemotional competence and may operate as resilience factors in the face of risk for psychopathology. The current proposal will examine how local and global neural markers of regulation develop in infancy, and how these trajectories are potentially influenced by (1) infant and maternal risk for psychopathology and (2) dyadic patterns in the mother-infant relationship. The current proposal also presents a direction for expanding this research in the postdoc phase, by integrating simultaneous assessments of neurocognitive mechanisms in mothers and children in relation to the socialization of regulation and psychopathology.

PI_NAMEs: ANAYA, BERENICE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Adult;Affect;Affective;Age;Anxiety;Attention;Award;base;Behavior;Behavioral;Brain;career;Child;Child Behavior;Child Rearing;Childhood;Code;Cognitive;cognitive system;Competence;contextual factors;Coupled;critical period;Cross-Sectional Studies;Data;design;Development;Developmental Course;dynamic system;early childhood;Educational process of instructing;Electroencephalography;Emotional;Environmental Risk Factor;Foundations;Frequencies;functional near infrared spectroscopy;Funding;Goals;graph theory;Individual;Individual Differences;individual variation;infancy;Infant;infant temperament;interest;Intervention;joint attention;Laboratories;Lead;Learning;Length;Link;Literature;Maps;maternal anxiety;Maternal Behavior;maternal risk;Measures;Mentors;Methodology;Methods;middle childhood;Modeling;Mother-Child Relations;Mothers;multilevel analysis;National Institute of Mental Health;negative affect;neural;Neural Canal;neural correlate;neural patterning;Neurocognitive;neurodevelopment;neuromechanism;Neurosciences;novel;Parent-Child Relations;parental role;parenting intervention;Parents;Pathway Analysis;Pattern;Phase;Play;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Postpartum Period;pre-clinical;pre-doctoral;Prevention;primary caregiver;Process;programs;Protocols documentation;Psychopathology;Regulation;Reporting;Research;Research Personnel;Research Project Grants;resilience;resilience factor;Resistance;response;Rest;Risk;Role;skills;social anxiety;Socialization;System;Systems Development;Technical Expertise;Techniques;Temperament;tenure track;therapy design;Time;Training;transmission process;Videotape;Visit;visual tracking;Work;Writing

PROJECT_TITLE: The neural foundations of regulation in infancy and the role of individual and environmental factors over time


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The proposed research plan will provide a link between enhancer-promoter interactions and the contributions of transcription factor binding to the regulation of gene expression. Robust descriptions of these events, in fixed and live cells of the differentiating Drosophila embryo and ovary, will give insight into the inner workings not only of eukaryotic cells generally, but also into the still poorly understood role of regulatory DNA and chromatin architecture relating to dysplasia and diseases; mutations in non-coding loci have been repeatedly implicated in their occurrence. Because many genes, pathways and regulatory mechanisms are shared between Drosophila and higher organisms, improved understanding of how complex loci are coordinated in flies is likely to inform new approaches to understand these phenomena in wild-type as well as developmental- and disease-relevant human contexts.

PI_NAMEs: STATHOPOULOS, ANGELIKE  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;Affect;Architecture;Binding;Binding Proteins;Biological Assay;Cell Differentiation process;Cells;Centromere;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Complex;Coupled;Cues;Data;Development;Disease;Distal;DNA;DNA Binding;Drosophila genus;Drosophila melanogaster;Dysplasia;Elements;Embryo;Enhancers;Eukaryotic Cell;Event;fly;Gene Expression;Gene Expression Regulation;Genes;genetic analysis;Genome;genomic locus;Genomics;Homeostasis;Human;Hybrids;Image;imaging approach;improved;in vivo;insight;Link;Maintenance;Molecular;Molecular Conformation;Mutagenesis;mutant;Mutation;novel strategies;Organism;Ovary;Pathway interactions;Pattern;Phenotype;promoter;Regulation;Reporter;Research;response;RNA Interference;Role;Stretching;System;Techniques;Testing;Time;Tissues;transcription factor;Untranslated RNA;whole genome

PROJECT_TITLE: Regulation of long distance enhancer-promoter interactions by promoter-proximal elements

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The ability to navigate complex environments and engage in effective goal-directed planned behaviors is a core human trait. The lack of spatial planning abilities results in debilitating capacities to negotiate known and novel environments and is associated with a variety of neurological disorders. Thus, understanding the neural computations that can support this behavior can help reveal the underlying causes of certain major neurological diseases.

PI_NAMEs: YARTSEV, MICHAEL MOSHE (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: The Emergence Persistence and Plasticity of Neural Codes for Self-Selected Goal-Directed Navigation


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In this renewal application we propose to advance a unique, innovative program on the discovery, development, validation, and application of novel radioligands for positron emission tomography imaging to probe high priority molecular targets involved in mental health disorders. Success of this program will contribute to the elucidation of the etiology and pathophysiology of mental diseases, and facilitate the development of effective treatments.

PI_NAMEs: CARSON, RICHARD E. (contact);HUANG, YIYUN HENRY

PROGRAM_OFFICER_NAME: BRADY, LINDA S

PROJECT_TERMS: Academia;Acetylcholine;Agonist;AMPA Receptors;Award;Basic Behavioral Science;Binding;Brain;Brain region;Chemical Structure;Chemistry;Clinical;Collaborations;Communities;Complex;Data;Decision Making;Dedications;Development;Disease;Dopamine;Dopamine D1 Receptor;dopamine transporter;drug candidate;effective therapy;Endocannabinoids;Etiology;Evaluation;Failure;first-in-human;Functional disorder;Funding;GABA Transporter 1;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Grant Review;HDAC6 gene;Human;Image;imaging properties;in vitro testing;in vivo;in vivo imaging;Industry;Infusion procedures;innovation;interest;kinetic model;Knowledge;Label;Lead;Ligands;meetings;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolism;Methods;Molecular;molecular imaging;Molecular Target;molecular targeted therapies;Monoacylglycerol Lipases;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;National Institute of Mental Health;neuropsychiatric disorder;Neurosciences;nonhuman primate;novel;Opioid;Play;Positron-Emission Tomography;Process;Program Evaluation;programs;Progress Reports;Psyche structure;Publications;radioligand;Radiometry;radiotracer;receptor;Research;research clinical testing;Resource Allocation;Risk;Role;Scheme;Schizophrenia;Scientist;Serotonin;Signal Transduction;success;symposium;System;Testing;therapeutic development;therapeutic target;tool;Tracer;Translating;uptake;Validation;validation studies;web site

PROJECT_TITLE: A Program for Innovative PET Radioligand Development and Application - A Translational Toolbox for Treatments for Mental Health


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is a common complication in post-surgical patients, and it significantly decreases patient quality of life and leads to increased rates of death. The proposed research in this grant application is relevant to public health because it seeks to understand the cellular mechanism of a novel kidney protective therapeutic that could be given prior to surgery or kidney transplantation to protect the kidney from injury. Thus, this proposal fulfills both aspects of the NIH's mission: to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: PRIVRATSKY, JAMIE R (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acetylation;Acute Renal Failure with Renal Papillary Necrosis;Agonist;Annexin A1;antagonist;Anti-Inflammatory Agents;Applications Grants;Behavior;Binding;Blood flow;Blood Vessels;Cell Death;Cells;Complication;cyclophilin D;Data;Deacetylase;Deacetylation;Death Rate;design;Development;disability;drug development;efficacy evaluation;Exposure to;Family;fMet-Leu-Phe receptor;FPR2 gene;G-Protein-Coupled Receptors;Genetic;Goals;Health;Human;improved outcome;Injury to Kidney;Interruption;Ischemia;Kidney;kidney cell;kidney epithelial cell;Kidney Transplantation;Knowledge;Life;Measures;Mediating;member;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;mimetics;Mission;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Morbidity - disease rate;mortality;Mus;Nature;Necrosis;nephrogenesis;novel;novel therapeutics;operation;Operative Surgical Procedures;Organ;organ injury;Organism;Oxidative Phosphorylation;Parents;Pathogenesis;Pathway interactions;Patients;Peptide Fragments;peptidomimetics;Perioperative;Permeability;Persons;post-transplant;Postoperative Period;PPAR gamma;Predisposition;prevent;Production;Property;Public Health;Quality of life;Renal function;renal ischemia;Renal tubule structure;Reperfusion Therapy;Research;Role;septic;Signal Pathway;Sirtuins;Specificity;Stress;Therapeutic;Transgenic Mice;Translating;translational study;Transplantation;Transplantation Surgery;Tubular formation;tubular necrosis;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Novel mitochondrial protective properties of annexin A1

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Natural Products;Prevention;Substance Misuse;Tobacco

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE There has been a rapid increase in the use of highly concentrated THC liquids inhaled by cannabis consumers through vaping devices. This project will utilize a combination of observational, laboratory, and clinical trial designs to provide timely and novel data on THC doses and speed of delivery from liquid THC concentrates used with vaping devices. This project will provide important information that will be relevant for prevention and treatment of problematic cannabis use, and future regulation of vaped cannabis products.

PI_NAMEs: GONIEWICZ, MACIEJ LUKASZ;SMITH, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acute;Appearance;Behavior;Behavior assessment;behavior influence;Cannabinoids;Cannabis;Cannabis retail;Characteristics;Clinical Trials Design;Data;design;Device Designs;Devices;Dose;Double-Blind Method;Drug Delivery Systems;Drug Kinetics;Electronic cigarette;Elements;Evaluation;evidence base;experience;Future;Generations;Goals;Heating;Human;human data;improved;Individual;Inhalation;innovation;Knowledge;Laboratories;laboratory experiment;Life;liquid formulation;Liquid substance;Literature;marijuana use;marijuana user;marijuana vaping;Methods;Nicotine;nicotine use;non-cannabinoid;novel;Observational Study;Participant;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Placebo Control;Population;Prevalence;Prevention;Procedures;Property;Randomized;randomized trial;recruit;Regulation;Reporting;Research;response;Risk;Safety;Self Administration;Smoke;Solvents;Speed;Temperature;Terpenes;Tetrahydrocannabinol;THC concentration;trend;trial design;United States;vaper;vaping;vaping nicotine;vaping THC

PROJECT_TITLE: Assessing pharmacokinetic and pharmacodynamic variability of Δ9-tetrahydrocannabinol delivered from vaping products with and without concurrent use of nicotine


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Reoviridae viruses include important pathogens of humans and animals as well as oncolytic viruses that kill cancer cells without harming patients. The proposed studies will provide insight into fundamental mechanisms of viral genetic diversity that are mediated by the assembly and transmission processes of viruses in the Reoviridae family. The impact of this research on human health will come from application of these fundamental principles to the rational engineering of improved vaccines, oncolytics, and other virus-based therapeutics and to the identification of factors that predict outcomes of coinfection and transmission for pathogenic Reoviridae viruses.

PI_NAMEs: OGDEN, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Animals;Anti-viral Response;Antibodies;Bar Codes;Biological Assay;cancer cell;Cells;co-infection;Collection;Complement;Cultured Cells;Cytoplasmic Inclusion;Data;Disease;Double-Stranded RNA;Electron Microscopy;Elements;Engineering;Exclusion;extracellular vesicles;Family;Fostering;Fractionation;Genes;Genetic;Genetic Enhancement;Genetic Polymorphism;Genetic Variation;Genome;Genomics;Goals;Health;Human;human pathogen;Image;imaging probe;improved;In Vitro;in vivo;Infection;insight;Interferons;Mediating;melting;Modeling;mouse model;Mus;new technology;next generation;Oncolytic;Oncolytic viruses;outcome prediction;Parents;particle;pathogen;Pathogenicity;Pathway interactions;Patients;Population;Predictive Factor;Preventive;Primary Infection;receptor;Recombinants;Reoviridae;Reovirus;Research;Resolution;response;reverse genetics;RNA;RNA Sequences;RNA Viruses;Shapes;Signal Transduction;superinfection;Symptoms;System;Testing;Therapeutic;Third Generation Sequencing;Time;tissue culture;transmission process;Travel;vaccine response;Vaccines;Vesicle;Viral;Viral Genes;viral RNA;viral transmission;Virulence;Virus;Virus Assembly;virus genetics;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Effects of Reoviridae assembly and transmission processes on viral genetic diversity

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Several tiers of regulation ensure that genes are properly expressed in cells. Cap structures added to the beginnings of messenger RNAs (mRNAs) are critical for their regulation and represent one such mechanism. Cytoplasmic capping is an understudied process that returns a cap onto uncapped mRNAs and is likely another layer of the cell’s regulatory framework. This work’s goals are to determine how targets are generated for the cytoplasmic capping machinery, how that machinery recognizes mRNAs and the effects of cytoplasmic capping on cellular proteins in normal and stressed conditions.

PI_NAMEs: KISS, DANIEL LOUIS (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: acute stress;Alternative Splicing;Automobile Driving;Biochemistry;Bioinformatics;biological adaptation to stress;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;data mining;Data Set;decapping enzyme;Dominant-Negative Mutation;Elements;endonuclease;Ensure;Enzymes;experimental study;Generations;Genes;Genetic Transcription;Goals;Harvest;in vivo;Knock-out;Label;Learning;Length;Maps;Messenger RNA;Methods;Methylation;Methyltransferase;Modification;Molecular;N-terminal;nanopore;Nuclear;Nuclear Export;Pattern;Phosphorylation;Phosphotransferases;Polyadenylation;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Process;Protein Truncation;Proteins;Publishing;recruit;Regulation;Regulatory Pathway;ribosome profiling;RNA;RNA Cap-Binding Proteins;RNA Processing;RNA Sequences;Site;Stress;Structure;Surveys;Transcription Initiation Site;transcriptome;transcriptome sequencing;Translation Initiation;Translations;Work

PROJECT_TITLE: Understanding the mechanisms that regulate cytoplasmic capping and defining its contributions to post-transcriptional gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking;Unintentional Childhood Injury

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative While many consequences of college risky drinking affect the students themselves (e.g., hangovers, embarrassment), other problems such as impaired driving jeopardize public safety and must be addressed. Reports show: 1) college student drinkers experience disproportionally more problems, including increased impaired driving, than other age groups, and 2) although over 1.3 million drivers in the U.S. are arrested for impaired driving annually, they only represent 1% of the estimated 121 million self-reported episodes of impaired driving each year. In response, we embarked on a new endeavor and developed a brief intervention to reduce resistance and tailor parents' experiences to change their permissiveness toward allowing underage drinking, and in turn, reduce student risky drinking and consequences.

PI_NAMEs: TURRISI, ROBERT J (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Affect;Age;age group;Age of Onset;Alcohol consumption;Alcohols;Automobile Driving;Behavior;brief intervention;Characteristics;Child Rearing;college;college drinker;college drinking;Communication;Consumption;Data;Dedications;design;drinking;Drunk driving;Education;Educational process of instructing;efficacy evaluation;evidence base;Expectancy;experience;Family;Funding;hangover;high risk drinking;Hour;impaired driving performance;Impairment;Injury;Intervention;Intervention Studies;Legal;Licensing;Life;Marital Status;Mediator;Modeling;Monitor;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Outcome;Paper;parental influence;parenting intervention;Parents;Patient Self-Report;peer;Performance;permissiveness;Persons;Pilot Projects;Policies;Prevention;Prevention approach;Prevention program;Prevention Research;primary outcome;Process;Public Health;Publishing;Report (document);Reporting;Research;Resistance;Resources;response;Risk Behaviors;Safety;secondary outcome;sex;skills training;social;statistics;student drinking;Students;Subgroup;substance use prevention;Surgeon;Teenagers;Testing;Theoretical model;Training;Translating;trend;underage drinking;university student;willingness

PROJECT_TITLE: Examining a Brief Parent Intervention to Reduce College Student Drinking and Consequences

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Glioblastoma ranks among the deadliest of all human cancers, with current therapies offering only palliation. In this research project, we will study a novel regulation of brain tumor cells that resemble stem cells and are often resistant to radiation and chemotherapy. Cellular metabolism and regulation have been reprogrammed by these brain tumor stem-like cells, revealing potential new treatments for patients afflicted with glioblastoma.

PI_NAMEs: AGNIHOTRI, SAMEER  (contact);RICH, JEREMY N

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adult;alpha ketoglutarate;angiogenesis;biomarker development;Brain;Brain Neoplasms;cancer stem cell;Caring;Cell Cycle;cell growth;Cell Proliferation;Cells;Cellular Metabolic Process;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Citric Acid Cycle;clinical efficacy;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Collaborations;conventional therapy;Dasatinib;demethylation;Development;Dioxygenases;DNA;Enzymes;Epigenetic Process;epigenome;epitranscriptome;epitranscriptomics;Event;Foundations;gain of function;Genetic;Genetic Transcription;Glioblastoma;Glioma;Growth;histone modification;Human;Immune;improved;in vivo;inhibitor;Invaded;Ionizing radiation;Isocitrate Dehydrogenase;kinase inhibitor;Knock-out;Link;loss of function;Maintenance;Malate Dehydrogenase;Malate-Aspartate Shuttle Pathway;Malates;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediator;Messenger RNA;Metabolic;Metabolic Control;Metabolism;Methylation;Mitochondria;Modeling;Molecular;Molecular Target;multidisciplinary;mutant;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oncogenic;overexpression;Oxaloacetates;oxidation;palliation;palliative chemotherapy;Pathway interactions;patient response;patient stratification;Patients;Pharmacodynamics;pharmacologic;Play;Population;Post-Transcriptional Regulation;pre-clinical;Production;programs;radiation resistance;Radiation therapy;radioresistant;Regulation;Reporting;Research Project Grants;response;RNA;RNA methylation;Role;self-renewal;small molecule inhibitor;standard of care;stem;stem cell biology;stem cell growth;stem cells;stem-like cell;stemness;synergism;targeted agent;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Transcript;Translating;Translations;Treatment Failure;treatment response;tumor;tumor growth

PROJECT_TITLE: Metabolic Regulation of Glioblastoma Epitranscriptomics

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Despite being cured of their tuberculosis (TB), millions of TB survivors each year suffer from chronic lung damage. Unfortunately, the nature of this lung damage is not well understood, which limits our ability to care for patients suffering from chronic lung disease after TB. By characterizing the role of neutrophilic and profibrotic activity as risk factors for post-TB lung damage, this study will inform future treatment strategies to prevent or reduce this devastating complication of TB.

PI_NAMEs: AULD, SARA  (contact);BISSON, GREGORY P.

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: acute infection;Address;Adult;advanced disease;Automobile Driving;Basement membrane;Binding;Biological;Biological Markers;Cause of Death;cell type;Cessation of life;Chronic;Chronic lung disease;Cicatrix;clinically significant;co-infection;Collagen;Communicable Diseases;Complication;Coughing;Data;Dedications;Deposition;Disease;Dyspnea;Enrollment;Enzymes;Epithelium;Exhalation;Extracellular Matrix;Fibrosis;Functional disorder;Future;Gene Expression;Goals;healing;Heterogeneity;High Resolution Computed Tomography;high risk;HIV;HIV Infections;HIV/TB;Human;immune activation;Immune response;immunopathology;Impairment;improved;Incidence;Inflammation;Intervention;Knowledge;Left;Leukocyte Elastase;Longitudinal Studies;Lung;Lung Diseases;Lung immune response;lung injury;Matrix Metalloproteinases;Measurement;Measures;Mediating;Mediator;Modification;mortality;Mycobacterium tuberculosis;Nature;neutrophil;Neutrophil Collagenase;Newly Diagnosed;novel;novel marker;Outcome;pathogen;Pathogenesis;Pathway interactions;Patient Care;Patients;Persons;Pharmaceutical Preparations;Physical condensation;Populations at Risk;Positron-Emission Tomography;Predisposition;prevent;Prospective cohort;pulmonary function;Pulmonary function tests;Pulmonary Tuberculosis;Quality-Adjusted Life Years;repaired;Research Design;Respiratory Signs and Symptoms;response;restoration;Risk;Risk Factors;Role;Sampling;secondary analysis;Severities;Site;South African;Sputum;Survivors;Syndrome;Testing;Therapeutic;Therapeutic Studies;therapy design;Thoracic Radiography;Time;Transforming Growth Factor beta;Transforming Growth Factors;translational study;treatment strategy;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;X-Ray Computed Tomography;years of life lost

PROJECT_TITLE: Inflammation and Fibrosis in Pulmonary TB: the INFIN-TB Study

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


PHR: Project Narrative The tRNA cleavage pathway is an emerging mechanism of gene expression regulation based on the production of various tRNA-derived fragments. This mechanism is critical not only for survival under adverse conditions but also implicated in many human diseases such as cancer and neurodegenerative diseases. Here we propose to systematically characterize biogenesis, functions and molecular mechanisms of tRNA-derived molecules.

PI_NAMEs: IVANOV, PAVEL  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Alanine-Specific tRNA;Amyotrophic Lateral Sclerosis;angiogenin;Anticodon;Apoptosis;Base Sequence;Binding;Biogenesis;biological adaptation to stress;Biological Process;Biology;Cell Physiology;Cell Reprogramming;Cell Survival;Cells;Cellular Stress;cohort;Communities;Complex;CRISPR/Cas technology;Custom;Cytoprotection;Data;Disease;Elements;Ensure;Future;Gene Expression;Gene Expression Regulation;Goals;Health;Human;human disease;Human Pathology;Immunity;In Vitro;innovation;insight;Investigation;Knowledge;Laboratories;Link;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Modeling;Molecular;Molecular Biology;mRNA Translation;Mutation;Neurodegenerative Disorders;new therapeutic target;novel;novel therapeutics;Nucleotides;Nutrient;overexpression;Parkinson Disease;Pathology;Pathway interactions;Patients;Play;Postdoctoral Fellow;Process;Production;programs;Property;protein aminoacid sequence;Protein Biosynthesis;Proteins;Proteomics;Reagent;Regulator Genes;Research;Research Personnel;Resources;response;Ribonucleases;ribosome profiling;Ribosomes;RNA;RNA Interference;Role;Signal Transduction;Source;Stress;Structure;System;targeted treatment;Technology;Testing;Therapeutic;Transcript;Transfer RNA;Translation Initiation;Translational Regulation;Translational Repression;Translations;Triplet Multiple Birth;Untranslated RNA;Work

PROJECT_TITLE: tRNA-derived stress-induced RNAs and translational control

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: Single-cell RNA-seq technologies have transformed the field of genomics and experiments are becoming widely used across both basic science and disease research. Yet, statistical methods and tools for analysis are exceedingly complex for non-experts and not adapted for more complex experimental designs. The proposed research programs will remove analytical barriers to analyzing scRNA-seq data and enable researchers to obtain deeper insights into their data by optimizing and streamlining their analyses without compromising on quality.

PI_NAMEs: BACHER, RHONDA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Basic Science;Biological;Complex;Computer software;Data;Data Analyses;Disease;Experimental Designs;experimental study;Genomics;Goals;improved;insight;interactive visualization;Methods;novel;programs;Reproducibility;Research;Research Personnel;Scientist;single cell analysis;single-cell RNA sequencing;Statistical Methods;Technology;tool;web server

PROJECT_TITLE: Resolving single-cell analysis challenges via data-driven decision frameworks and novel statistical methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Kidney Disease

PHR: Chronic kidney disease (CKD) affects almost 15% of Americans and greatly increases the risk of cardiovascular disease. This proposal will improve our understanding of how the cell cycle and metabolism in chronically injured tubules affects tubule function and the development of fibrosis. If successful, these studies may also reveal novel therapeutic targets for slowing the progression of CKD.

PI_NAMEs: GEWIN, LESLIE S (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;Affect;American;anaerobic glycolysis;Apoptosis;Autocrine Communication;cardiovascular disorder risk;Catalytic Domain;CDK4 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Respiration;Cells;Cellular Metabolic Process;Chronic;Chronic Kidney Failure;Citric Acid Cycle;conditional knockout;Cyclin D1;Cyclin-Dependent Kinases;Cyclins;cytokine;Data;Development;disease model;DNA biosynthesis;Electron Transport;Environment;Enzymes;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;fatty acid oxidation;FDA approved;Fibrosis;G2/M Arrest;Genetic;Genus Hippocampus;Glucose;glucose metabolism;Glycolysis;Hypoxia;improved;in vitro activity;in vivo;Inflammation;Inflammatory;injured;Injury;Injury to Kidney;innovation;Kidney;Kidney Diseases;kidney fibrosis;kidney metabolism;Knockout Mice;Lactic acid;Link;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Mitosis;mouse model;Mus;Myofibroblast;Natural regeneration;new therapeutic target;novel;Nutrient;oxidation;Paracrine Communication;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;preclinical study;Process;Proliferating;Pyruvate;Renal tubule structure;repaired;Resolution;response;response to injury;Rodent;Role;S phase;Signal Pathway;Signal Transduction;stable isotope;Structure;superresolution microscopy;Testing;Tissues;tool;Tubular formation

PROJECT_TITLE: Cell Cycle and Metabolism in Chronically Injured Renal Tubules


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PATHOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: This project will further establish a novel and promising model of late-onset sporadic Alzheimer’s disease – the most common type – in vervet monkeys. Development of this novel animal model will yield insights into the causes and early neuropathology of Alzheimer’s disease, and identify promising targets for early intervention that could alter the course of this devastating disease.

PI_NAMEs: CRAFT, SUZANNE ;SHIVELY, CAROL A. (contact);WHITLOW, CHRISTOPHER T

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: abeta accumulation;Achievement;Adult;Affect;African Green Monkey;Age;age related;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Biological Markers;Biological Specimen Banks;biomarker identification;Blood;Blood Pressure;Brain;brain tissue;brain volume;Capsicum;Central Nervous System;Cercopithecus tantalus;Cerebrospinal Fluid;Cerebrum;Characteristics;Clinical Trials;clinically relevant;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cohort;Collaborations;Collection;Complex;Data;data repository;Dementia;Development;Disease;Disease Progression;Early Intervention;Early Onset Familial Alzheimer's Disease;Endocrine;Environment;Etiology;FDA approved;Gene Expression Profile;Genes;Glucose;Glucose Intolerance;glucose metabolism;Goals;Human;Hypertension;Image;image archival system;imaging biomarker;imaging capabilities;imaging study;Impaired cognition;impaired glucose tolerance;Incidence;innovation;insight;Intervention;Late Onset Alzheimer Disease;Liquid substance;Magnetic Resonance Imaging;Microtubules;Modeling;modifiable risk;motor deficit;Neurocognitive Deficit;Neurofibrillary Tangles;neuropathology;nonhuman primate;novel;Obesity;Outcome;overexpression;Persons;Phylogenetic Analysis;Physical activity;Physical Function;poor sleep;Positron-Emission Tomography;Predictive Value;Protocols documentation;Psychosocial Stress;repository;Research;resilience;Resistance;Resources;response;Risk Factors;Senile Plaques;Sequence Homology;Sleep;social;Stress;Structure;study characteristics;symptomatology;Symptoms;tau aggregation;tau Proteins;Tracer;Transgenic Mice;Transgenic Model;Translating;translational potential;vervet

PROJECT_TITLE: Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and Symptomatology


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Chronic HIV is a serious medial problem for which there is no cure. The reservoir of HIV in the brain is a major challenge, causing high morbidity, and because drugs cannot cross the blood brain barrier, eradication of the virus is impossible. We propose a solution to this problem by intra-arterial transplantation of glial-restricted progenitors, engineered to express HIV neutralizing antibodies.

PI_NAMEs: HEREDIA, ALONSO ;WALCZAK, PIOTR  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Address;Adverse effects;Animal Model;Anti-Retroviral Agents;Antibodies;Antibody Formation;antiretroviral therapy;Arteriogram;Astrocytes;Binding;Binding Sites;Biological Products;bioluminescence imaging;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain cell;brain parenchyma;Cardiovascular system;Cells;cerebrovascular;Chronic;Clinical;clinical development;Cognitive;comorbidity;Development;Diffusion;dosage;Dose;Drug resistance;engineered stem cells;Engineering;Engraftment;experience;Face;Genetic Engineering;Goals;GRP gene;HIV;HIV Envelope Protein gp120;HIV Infections;HIV therapy;HIV-associated neurocognitive disorder;Human;image guided;Individual;Infection;innovation;Intra-Arterial Infusions;Intra-Arterial Injections;Ischemia;Lymphocyte;Macrophage;Magnetic Resonance Imaging;Medial;Metabolic;Methodology;Methods;Microglia;Modeling;Moods;Morbidity - disease rate;Motor;Mus;neuroinflammation;Neurologic;Neuropathogenesis;neutralizing antibody;novel;novel strategies;novel therapeutics;Oligodendroglia;Penetration;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Positioning Attribute;Positron-Emission Tomography;Predisposition;prevent;Production;progenitor;Property;Reproducibility;Research;resistant strain;Risk;Safety;stem cell therapy;stem cells;Testing;Therapeutic;Therapeutic Agents;Time;tool;Toxic effect;trafficking;Translating;Transplantation;vector;Vial device;Viral;Viral Load result;Viremia;Virus;Work

PROJECT_TITLE: Image-guided intra-arterial administration of antibody-releasing glial progenitors to control the HIV CNS reservoir.


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Prevention

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

PHR: Narrative: Complex diseases frustrate patients and create a burden on healthcare systems with multiple inpatient hospitalizations and frequent testing. Creating a pathway that would allow physicians to utilize genetic information for real time genetic diagnosis could prevent much of this burden. Utilizing a High Impact Phenotype Identification System (HIPIS) we would like to develop dynamic virtual genetic panels that should impact clinicians' decisions at point of care.

PI_NAMEs: WILLIAMS, MARC S. (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Affect;Algorithms;Area;Bioinformatics;care outcomes;Caregivers;Caring;causal variant;Clinical;clinical care;Clinical Data;Clinical Engineering;Clinical Management;Clinical Research;clinically relevant;cohort;Collaborations;Complex;Data;Databases;Development;Diagnosis;Diagnostic;Disease;disease-causing mutation;Documentation;Electronic Health Record;Eligibility Determination;Emotional;Expenditure;experience;Family;Frustration;Genes;Genetic;genetic association;Genetic Diseases;genetic disorder diagnosis;genetic information;genetic resource;genetic testing;genetic variant;Genomics;Grief reaction;Health;Health Personnel;Healthcare Systems;Heart;Hospitalization;Hospitals;Human;improved;improved outcome;in silico;Individual;innovation;Inpatients;Life Style;Link;Manuals;Medical Records;medical specialties;Mind;Outcome;Outpatients;Pathogenicity;Pathway interactions;Patient Care;Patient Schedules;Patient-Focused Outcomes;Patients;Penetrance;Persons;Phenotype;Physicians;point of care;Population;prevent;Preventive;Primary Care Physician;Procedures;Process;Provider;psychologic;rapid diagnosis;Research;Resources;Role;Sensitivity and Specificity;Signs and Symptoms;System;Taxes;Test Result;Testing;Time;Uncertainty;Underserved Population;Variant;virtual;Vision;Visit;Work

PROJECT_TITLE: Real-time genetic diagnosis at the point of care


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

PHR: Project Narrative The present project aims to determine if there are sex differences in the neurobiological mechanisms underlying the formation of alcohol-associated memories or their modulation by acute stressors that mediate increased vulnerability to relapse in females. We will use a rodent model to determine if there are sex differences in 1) the amygdala-dependent plasticity that underlies alcohol-related learning, 2) the modulation of alcohol-associated neural ensembles by stress, or 3) the circuits activated by alcohol cues and stress, in order to identify potential targets for sex-specific treatment development.

PI_NAMEs: TORREGROSSA, MARY M (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;acute stress;Adult;Alcohol abuse;Alcohol consumption;alcohol craving;alcohol cue;alcohol exposure;alcohol memory;alcohol relapse;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohol-Related Disorders;Alcohols;Amygdaloid structure;Behavior;Behavioral;binge drinking;Brain;Brain region;calcium indicator;Calcium Signaling;Clinical;Cocaine;cocaine relapse;craving;Cue-induced relapse;Cues;Data;Dependence;Development;Electrophysiology (science);epidemiologic data;epidemiology study;Excitatory Amino Acid Antagonists;Exposure to;Extinction;Female;Gender;Generations;Genetic;Glutamatergic Agents;glutamatergic signaling;Glutamates;Gonadal Hormones;Health;high risk drinking;Homosynaptic Depression;Hormones;Human;Immunohistochemistry;improved;in vivo;Individual;Intervention;Laboratory Study;Learning;Life;male;Maps;Measures;Mediating;Memory;men;microendoscope;microscopic imaging;Modeling;nerve supply;neural;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Neurons;NMDA receptor antagonist;noradrenergic;Outcome;Pattern;Pharmaceutical Preparations;pharmacologic;Population Dynamics;Predisposition;psychologic;Rattus;recruit;Regulation;Relapse;Reporting;response;Rewards;Risk;Rodent Model;Self Administration;Sensory;sex;Sex Differences;sexual dimorphism;Shock;Slice;social;Stress;stressor;Synapses;Testing;Thalamic structure;therapy development;Training;treatment effect;Woman;Women's cohort;Yohimbine

PROJECT_TITLE: Mechanisms underlying sex differences in stress-induced alcohol seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: Public Health Statement Vascular health is an important factor in the development of neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases We propose to develop a method that can produce quantifiable images of multiple blood flow related parameters with a single scan and without the use of contrast injections. We will use this method to gain a better understanding of the relationship between Parkinson’s disease and cerebral blood flow, and expect that our method will have multiple applications beside Parkinson’s disease.

PI_NAMEs: HERNANDEZ-GARCIA, LUIS  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;aging brain;Agreement;Algorithms;Alzheimer's Disease;arterial spin labeling;Arteries;Binding;Biological;Biological Markers;Blood flow;Blood Vessels;Blood Volume;Bolus Infusion;Brain;Cerebrovascular Circulation;Classification;Clinic;Clinical;Contrast Media;deep learning;Development;Diagnosis;Disease;Ensure;Etiology;Fatigue;feeding;Fingerprint;Future;Health;hemodynamics;Human Volunteers;Hybrids;Image;imaging biomarker;improved;Injections;insight;interest;Knowledge;Label;machine learning algorithm;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Memory;Methodology;Methods;Modeling;Movement;Nerve Degeneration;neural;neural network;Neurodegenerative Disorders;Neuronal Injury;Noise;non-invasive imaging;novel therapeutics;Parameter Estimation;Parkinson Disease;Pathogenesis;Pathologic;patient stratification;Patients;Perfusion;perfusion imaging;Physiologic pulse;Public Health;Reproducibility;Research;Risk Assessment;Scanning;Sensitivity and Specificity;Severities;Signal Transduction;Spatial Distribution;Specificity;Stratification Factors;success;support vector machine;Symptoms;Techniques;Testing;therapeutic target;Time;Tissues;tool;Translating;Validation;vascular factor;vector;Weight;white matter;Work

PROJECT_TITLE: Quantitative MR Imaging of Vascular Factors in Parkinsons Disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: OVERALL PROJECT NARRATIVE The Yale Superfund Research and Training Program (YSRTP) is motivated by community-based concerns about emerging drinking water contaminants. The program will engage in problem-based, solution-oriented research related to 1,4-dioxane, an emerging water contaminant of particular concern because it is widespread and persistent in the environment, poorly regulated, has consistently shown carcinogenic effects, co-occurs with toxic chlorinated solvent contaminants (1,1,1-trichloroethane, 1,1-dichloroethane and 1,1,1-trichloroethylene), and is not mitigated using standard approaches. This proposal will address critical gaps in our understanding of cancer mechanisms, mixtures interactions, and detection and treatment technologies through innovative techniques that will inform risk assessment and regulatory standard-setting as well as help affected communities address health questions and remove this contaminant from water supplies.

PI_NAMEs: VASILIOU, VASILIS  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Achievement;Address;Affect;American;Animal Model;Animals;Attention;Biological;Biological Markers;Biomedical Research;carcinogenicity;Carcinogens;Chemicals;Classification;Communication;Communities;community engaged approach;community engagement;Community Health Education;Consumption;contaminated drinking water;cost effective;Data;Detection;Development;Dioxanes;drinking water;Education;Ensure;Environment;Environmental Engineering technology;Environmental Pollution;Environmental Science;epidemiology study;Ethylene Dichlorides;Evaluation;exposed human population;Exposure to;Fostering;Foundations;Fright;Future;Genetic;Goals;Health;Health Status;Hepatocarcinogenesis;Hepatotoxicity;Human;improved;Incidence;Industrialization;innovation;interdisciplinary approach;International Agency for Research on Cancer;Knowledge;Lead;Link;Liver;Long Island;Malignant neoplasm of liver;Malignant Neoplasms;Medial;Methods;Modeling;Monitor;Mus;Notification;novel;Occupations;oxidation;Physiological;Population;Process;programs;public drinking;Public Health;public health priorities;Regulation;Research;Research Project Grants;Research Technics;Resources;response;Risk;Risk Assessment;Science;Scientist;sensor;Signal Recognition Particle;Site;Solvents;Superfund;superfund site;System;Techniques;Technology;Testing;Time;Toxicology;Training;Training Programs;Translational Research;Trichloroethanes;Trichloroethylene;wasting;Water;Water Pollutants;Water Purification;Water Supply;Zebrafish

PROJECT_TITLE: Emerging Water Contaminants: Investigating and Mitigating Exposures and Health Risks


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Foodborne Illness;Genetics;Liver Cancer;Liver Disease;Rare Diseases

PHR: PROJECT NARRATIVE The goals of this project are to identify molecular mechanisms involved in 1,4-dioxane (1,4-DX) liver carcinogenicity and to assess the capacity of co-occurring contaminants (TCE and 1,1-DCA) in modifying 1,4- DX carcinogenicity. We propose to examine the mechanistic roles of key redox pathways and biological network motifs in 1,4-DX-induced liver carcinogenesis and elucidate the carcinogenic potential of co-occurring contaminant mixtures. This research will establish the dose response for key perturbations that are associated with 1,4-DX liver carcinogenicity and reveal whether unique susceptibility factors may predispose to a greater risk of liver carcinogenesis.

PI_NAMEs: CHEN, YING  (contact)

PROJECT_TERMS: adverse outcome;Animals;Biological;Biological Markers;Biological Models;carcinogenicity;Carcinogens;Cells;Chemicals;Chronic;Classification;Communication;CYP2E1 gene;cytotoxicity;Data Analyses;Development;Dioxanes;DNA Damage;Dose;drinking water;Ethylene Dichlorides;Event;exposed human population;Exposure to;Fostering;Gamma-H2AX;GCLC gene;GCLM gene;Gene Modified;Genetic;genotoxicity;Glutathione;Goals;Health;Hepatocarcinogenesis;Hepatocyte;Hepatotoxicity;high throughput screening;Homeostasis;Human;In Vitro;in vitro Assay;in vivo;International Agency for Research on Cancer;Lipid Peroxidation;Liver;liver cancer model;Long Island;Malignant neoplasm of liver;Malignant Neoplasms;metabolomics;Molecular;Molecular Target;mouse model;Mouse Strains;multiple omics;Mus;novel;NQO1 gene;Oncogenes;Organ;oxidation;Oxidation-Reduction;Pathway interactions;Pattern;Persons;Phase;Phenotype;Plasma;Predisposition;Process;programs;promoter;Proteins;Rattus;Reactive Oxygen Species;Research;Resources;response;Risk;Role;Safety;screening;Site;sound;Source;stem;Subgroup;Superfund;Time;Toxic effect;transcriptome sequencing;Transgenic Organisms;translational potential;Translational Research;Trichloroethylene;tumor;Uncertainty;Urine;Water Pollutants;Xenobiotics;Zebrafish

PROJECT_TITLE: Project 1 - Toxicity and Liver Carcinogenicity of 1,4-Dioxane: Single Chemical and Mixtures Studies


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A blood-brain barrier (BBB) comprised of multiple different cell types in and around blood vessels shields the brain but is unfortunately damaged in diseases such as stroke, causing bleeding, swelling and entry of potentially injurious substances. Our application examines how the GPR124/RECK/WNT7 pathway ensures normal BBB function and how drugs targeting this pathway can therapeutically stabilize the BBB to improve stroke treatment.

PI_NAMEs: KUO, CALVIN J (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Adhesions;Adult;Agonist;angiogenesis;Architecture;Astrocytes;beta catenin;Binding;Biochemical;Biology;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain Neoplasms;cell type;Cells;Central Nervous System;Cerebral endothelium;Cerebrovascular system;Cerebrum;clinical translation;Co-Immunoprecipitations;Complex;Coupling;crosslink;Data;Development;Disease;Doxycycline;Drug Targeting;Embryo;Embryonic Development;Endothelium;Ensure;Event;Extracellular Domain;Family;fascinate;FZD4 gene;G-Protein-Coupled Receptors;gain of function;Genetic;Glioblastoma;Goals;GPI Membrane Anchors;Grant;Health;Hemorrhage;Human;imaging study;improved;improved outcome;In Vitro;in vivo;induced pluripotent stem cell;Integral Membrane Protein;interdisciplinary approach;Investigation;Kinetics;Knock-out;Ligands;Link;live cell imaging;Measures;member;Membrane Proteins;Middle Cerebral Artery Occlusion;Modeling;Molecular;monomer;Multiple Sclerosis;Mus;Neoplasms;Neuroglia;Neurons;neurovascular unit;novel;Organoids;overexpression;Pathologic;Pathway interactions;Pericytes;pharmacologic;Phenotype;post stroke;pre-clinical;preservation;Production;Proteins;receptor;Recombinants;Reporting;Resolution;Role;Science;Signal Transduction;single molecule;Solubility;Stroke;stroke model;stroke therapy;Swelling;synergism;System;Testing;Therapeutic;Therapeutic Studies;therapeutic target;Time;Transfection;translational potential;Translational Research;Translations;vascular bed;WNT7A gene

PROJECT_TITLE: Mechanistic and Therapeutic Studies of GPR124/RECK/WNT7-Regulated Blood-Brain Barrier Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-M(91)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Foodborne Illness;Liver Disease;Prevention

PHR: Project Narrative The industrial chemical 1,4-dioxane has been identified as a drinking water contaminant throughout the United States and has been classified as a probable human carcinogen based on evidence from experimental animal studies. Human exposure and health impacts of 1,4-dioxane remain poorly understood in part because traditional techniques cannot detect low-level concentrations of 1,4-dioxane in biological samples or drinking water samples. To address the goals of the Superfund Research Program, our study will use a more sensitive approach to measure human exposure to 1,4-DX and its co-occurring contaminants, and assess links to early biological effects to determine the potential health impact for residents of Long Island, New York, an area with many Superfund sites potentially affected by 1,4-DX.

PI_NAMEs: DEZIEL, NICOLE  (contact)

PROJECT_TERMS: Address;Adult;Affect;Animal Experiments;Area;Awareness;Biological;Biological Assay;Biological Markers;Biological Monitoring;biomarker validation;Blood;Blood specimen;cancer risk;candidate selection;Carcinogens;Chemicals;Classification;Clinical;cohort;Communication;Communities;community engagement;contaminated drinking water;County;Cross-Sectional Studies;Data;Data Analyses;data management;Dioxanes;Disease;drinking water;Environment;Ethylene Dichlorides;Evaluation;exposed human population;Exposure to;Fright;Goals;ground water;Guidelines;Hazardous Substances;Health;health data;Hepatocarcinogenesis;Hepatotoxicity;High Prevalence;Home;Human;Individual;Industrialization;insight;Link;Lipids;Literature;Liver;Long Island;Mass Spectrum Analysis;Measures;metabolome;metabolomics;Municipalities;new technology;New York;North Carolina;novel marker;novel strategies;Participant;personal care products;Policy Maker;pollutant;Population;Probability;programs;public drinking;Questionnaires;remediation;Research;Research Personnel;response;Risk;Sampling;sensor;Serum;Site;Solvents;Source;Superfund;superfund site;Surface;System;Techniques;Test Result;Time;tool;Translational Research;Trichloroethanes;Trichloroethylene;United States;United States Environmental Protection Agency;Variant;volatile organic compound;Water;Water Pollutants;water sampling;water sampling/testing;Water Supply;water testing

PROJECT_TITLE: Evaluation of novel markers of exposure and biological response to 1,4-dioxane


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Foodborne Illness;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE: RELEVANCE TO PUBLIC HEALTH  Groundwater often serves as a source for drinking water supply. Near Superfund sites, groundwater can be  contaminated with a wide range of chemicals. Individuals exposed to these hazardous chemicals through  contaminated drinking water can be subjected to adverse health effects. Because current analytical methods to  detect hazardous chemicals involve expensive and time-consuming laboratory analyses, monitoring public  exposure necessitates development of new, rapid, low cost approaches to measure water contaminants. Sensor  technologies and wireless sensor networks embedded in drinking water systems can provide rapid on-site  detection and monitoring of target contaminants, thus enhancing the safety of drinking water and protecting  human health.

PI_NAMEs: GENTNER, DREW R (contact)

PROJECT_TERMS: Affinity;Air;analytical method;anthropogenesis;Antibody Affinity;aptamer;Binding;Biological Assay;Biosensor;Charge;chemical reaction;Chemicals;Cities;Collaborations;combinatorial;Communities;community engagement;Computers;Consumption;contaminant transport;contaminated drinking water;copolymer;cost;Data;Data Analyses;data management;Detection;detection limit;Development;Devices;Diagnostic;Dioxanes;DNA;drinking water;Effectiveness;Elements;Encapsulated;Epitopes;Equilibrium;Ethylene Dichlorides;Event;exposed human population;Exposure to;Extravasation;field study;Gas Chromatography;Gases;Goals;ground water;Hazardous Chemicals;Health;Human;Hydrophobicity;Immunoglobulin Fragments;improved;In Situ;Individual;Infrastructure;innovation;Interruption;Laboratories;Libraries;Lipids;Liposomes;Measurable;Measurement;Measures;Methods;Modeling;Molecular Weight;Monitor;nanobodies;Natural Source;Oligonucleotides;oxidation;Phase;photoionization;Plants;portability;Prevalence;Process;Property;Proxy;Public Health;purge;Quartz;Reagent;real time monitoring;receptor;remediation;Research;response;Risk;Safety;sensor;sensor technology;Signal Transduction;Site;Solubility;Solvents;Source;spatiotemporal;Specificity;superfund site;System;Techniques;Time;Toxic Environmental Substances;Trichloroethanes;Trichloroethylene;Vacuum;Vesicle;Water;Water Pollutants;water sampling;Water Supply;water testing;water treatment;waterborne;well water;wireless network;wireless sensor;Yeasts

PROJECT_TITLE: SENSORS FOR WATER CONTAMINANT DETECTION AND MONITORING


PHR: NARRATIVE Our overarching goal is to design, fabricate, test, and implement point-of-use small-scale water treatment units that can destroy 1,4-dioxane and its frequently co-occurring pollutants from contaminated ground water through advanced oxidation. Unlike any existing advanced oxidation processes, these reactors will not require continuous chemical supply and will use minimal energy. The prototype reactors will be tested both in the lab and in the field sites in Region 1 in collaboration with other project teams to verify the feasibility of real world use, to confirm the elimination of human toxicity, and to establish faster technology transfer.

PI_NAMEs: KIM, JAEHONG  (contact)

PROJECT_TITLE: Modular, Chemical-Free Advanced Oxidation of 1,4-Dioxane and its Co-Contaminants in Ground Water


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetic Testing;Genetics;Health Services;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR:  Project Narrative Pancreatic cancer is the deadliest of the common cancers and one of commonest causes of cancer death. Detecting pancreatic cancer at an early stage greatly improves survival from pancreatic cancer. We propose to validate the diagnostic accuracy of a tumor marker gene blood test for pancreatic cancer early detection and use this test in a clinical trial to improve the early detection of pancreatic cancer for patients with an increased susceptibility to pancreatic cancer undergoing pancreatic screening.

PI_NAMEs: GOGGINS, MICHAEL G. (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Affect;Aneuploidy;Atrophic;bariatric surgery;biobank;Biological Markers;biomarker panel;Blood Tests;CA-125 Antigen;CA-19-9 Antigen;Cancer Detection;Cancer Etiology;cancer imaging;cancer risk;Carboxypeptidase;Cessation of life;circulating biomarkers;Clinical;Clinical Chemistry;Clinical Trials;cohort;cone-beam computed tomography;Data Collection;Databases;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic panel;Diagnostic Sensitivity;Diagnostic tests;diagnostic value;Disease;disorder control;Early Diagnosis;Evaluation;Fatty acid glycerol esters;FDA approved;Future;Genetic;Genetic Markers;Genetic Predisposition to Disease;genetic testing;genetic variant;Genotype;glycosylation;high risk;high risk population;Hyperlipidemia;Image;improved;improved outcome;Individual;Investigation;Lead;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic syndrome;molecular diagnostics;Monitor;Outcome;Pancreas;pancreas imaging;pancreatic cancer patients;patient subsets;Patient-Focused Outcomes;Patients;Performance;Predisposition;programs;prospective;Protocols documentation;Recommendation;Reference Values;Resectable;screening;Screening for cancer;SEER Program;Serum;Specificity;Subgroup;surveillance imaging;Testing;Time;tumor;Tumor Burden;Tumor Markers;Validation;Variant

PROJECT_TITLE: Using Markers to Improve Pancreatic Cancer Screening

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Foodborne Illness

PHR: PROJECT NARRATIVE- ADMINISTRATIVE CORE The overarching aim of the Administrative Core (AC) is to ensure the success of the Yale Superfund Research and Training Program (YSRTP) in advancing public health through effective leadership and oversight. The AC will coordinate the translation of the YSRTP research that entails new knowledge about adverse health effects, exposure detection, fate and remediation of emerging water contaminants, and integrate its efforts with other Superfund Research and Training Programs and the NIEHS to have a greater national (and international) impact.

PROJECT_TERMS: Achievement;Address;Administrative Personnel;Administrator;Advisory Committees;Biological Markers;Biomedical Research;career;catalyst;Collaborations;Communication;community engagement;Data Analyses;data management;Department chair;Detection;Dioxanes;Doctor of Philosophy;drinking water;Ensure;Environmental Engineering technology;Environmental Health;Environmental Science;Epidemiology;Ethylene Dichlorides;experience;Exposure to;Extramural Activities;Fostering;Goals;Health;Human;Human Resources;Infrastructure;Institution;interdisciplinary collaboration;interest;International;Jordan;Knowledge;Lead;Leadership;Malignant neoplasm of liver;member;Mission;multidisciplinary;National Institute of Environmental Health Sciences;oxidation;Policies;Population;Productivity;professor;Program Research Project Grants;programs;Public Health;Public Health Schools;Publications;Qualifying;Recording of previous events;remediation;Research;Research Personnel;Research Project Grants;Resources;Risk;Schools;Science;Scientist;sensor;success;Superfund;superfund site;Toxic effect;Training;Training Programs;translational engagement;Translational Research;Translations;Trichloroethanes;Trichloroethylene;Universities;Water Pollutants;Water Supply;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Acid-sensing ion channels, membrane proteins found throughout the brain and body, activate when extracellular pH becomes more acidic and this can lead to a host of cellular responses. Using cutting edge electrical and optical methods we are investigating how pH causes these channels to open and close, what movements they make and what other proteins they may interact with. Our results will provide important insights into the operation of these proteins, furthering basic research while potentially informing drug design and therapeutic development.

PI_NAMEs: MACLEAN, DAVID MALCOM (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Ablation;Acids;Address;Amino Acids;ASIC channel;Attenuated;Baroreflex;Basic Science;Biophysics;Brain;cancer cell;Cardiac;Cell Death;cell type;Chickens;Coupling;Cryoelectron Microscopy;Data;desensitization;Drug Design;drug development;Electrophysiology (science);epithelial to mesenchymal transition;Event;Exhibits;experimental study;extracellular;Extracellular Domain;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fright;Genetic;Impairment;innovation;insight;Investigation;Ion Channel Gating;Ion Channel Protein;Ischemic Stroke;Knowledge;Label;Learning;Link;Maps;Mediating;Membrane Proteins;Methods;Molecular;Molecular Conformation;Motion;Movement;Nervous System;Neurons;operation;Optical Methods;Pain;patch clamp;pharmacologic;Phenotype;protein protein interaction;Proteins;protonation;Regulation;Reporting;response;Rest;Role;scaffold;Signal Transduction;Site;Structure;Testing;therapeutic development;Toxin

PROJECT_TITLE: Acid-Sensing Ion Channel gating: Conformations and Consequences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Foodborne Illness;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative: On behalf of the Yale Superfund Research Training Program (YSRTP), the Data Management and Analysis Core (DMAC) will provide the YSRTP with a state of the art data management, bioinformatics and environmental statistics infrastructure that will serve as a focal point for integrated data management and analytics across YSRTP projects and cores. DMAC will also serve as a hub for providing feedback to project scientists to drive further scientific investigations and innovation to advance the aims and objectives of the YSRTP.

PI_NAMEs: PEDUZZI, PETER NATALE (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Applications Grants;Bioinformatics;biomedical informatics;Biometry;Clinical;Collaborations;Communication;Consultations;Data;data access;Data Analyses;Data Analytics;Data Collection;Data Correlations;data integration;data interoperability;data management;data quality;data repository;Data Security;Data Set;data sharing;data standards;design;Detection;detection limit;Development;Doctor of Philosophy;drinking water;Evaluation;experience;Experimental Designs;Faculty;Feedback;Fostering;Funding;Genomics;Goals;Health;high dimensionality;improved;Individual;Information Systems;Infrastructure;innovation;innovative technologies;interoperability;Investigation;large datasets;Link;Location;Medical center;Medical Informatics;meetings;Methodology;Methods;Monitor;Ontology;open data;Play;Policies;Postdoctoral Fellow;pre-doctoral;Preparation;Program Research Project Grants;programs;Proteomics;Public Health Informatics;Public Health Schools;Qualifying;quality assurance;Quality Control;Recommendation;Research;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Risk Assessment;Role;Sample Size;Schedule;Science;Scientist;Secure;spatiotemporal;statistical center;Statistical Data Interpretation;statistics;Suggestion;Superfund;Terminology;Testing;Toxicology;Training and Education;Training Programs;Water Pollutants;Work

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The uncertainty about risk and appropriate courses of action surrounding emerging contaminants in drinking water, such as 1,4-dioxane (1,4-DX), creates an atmosphere of confusion, blame, anxiety and mistrust in communities impacted by these issues. The focus of the Community Engagement Core (CEC) in the Yale Superfund Research and Training Program (YSRTP) is to address these challenges through facilitation of engagement and information exchange among diverse constituencies in two states currently impacted by 1,4- DX issues (i.e., New York and New Hampshire). The CEC will create opportunities for stakeholders – including residents, government agencies, community and educational organizations – to learn from each other, and by utilizing multilateral partnerships among the projects in the YSRTP, will strengthen relationships across stakeholder groups, foster educational opportunities, and promote active and sustained community engagement.

PI_NAMEs: HERZ KAMINSKI, IRIS  (contact)

PROJECT_TERMS: Acute;Address;Advocate;Affect;Anxiety;Area;Atmosphere;Cities;citizen science;Collaborations;Communication;Communities;community academic partnership;community empowerment;community engaged approach;community engagement;Community Health;Complement;Confusion;contaminated drinking water;County;Data;Dioxanes;Doctor of Philosophy;drinking water;economic disparity;Education;Education and Outreach;Educational Materials;empowerment;Ensure;Environment;environmental justice;Equity;Evaluation;experience;Exposure to;Fostering;Goals;Government;Government Agencies;Greenland;ground water;Health;health assessment;Health Policy;Home;Human;improved;Individual;interest;Intervention;Investments;Knowledge;landfill;Lateral;Leadership;Learning;Long Island;member;Methods;Modeling;Monitor;New England;New Hampshire;New Jersey;New York;next generation;North Carolina;outreach;Phase;Population;Prevention;Process;Program Research Project Grants;public drinking;Public Health;Public Policy;Puerto Rico;Recording of previous events;remediation;Research;Research Personnel;Research Project Grants;Resolution;Resources;Risk;Scientist;Services;Site;skills;Solvents;Superfund;superfund site;Technology;Testing;tool;Training;Training Programs;Translating;Translational Research;tribal Nation;Uncertainty;United States Virgin Islands;Universities;Visit;vulnerable community;Water;Water Pollutants;water quality;Water Supply;well water;Work

PROJECT_TITLE: Community Engagement Core