NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: HARRIS, BRENT T (contact)

PROJECT_TERMS: Advisory Committees;Age;Animal Model;anti-cancer research;Antibodies;Autopsy;Basic Science;biobank;Biological Assay;Biological Markers;Biology;biomedical informatics;Blood;Brightfield Microscopy;cancer cell;Cancer Center Support Grant;Cancer Control;cancer prevention;Cellular biology;Center for Translational Science Activities;Clinic;Clinical;Clinical Data;Clinical Trials;Collaborations;Collection;Comprehensive Cancer Center;Consent;Consultations;data acquisition;Data Analyses;Databases;demographics;Diagnostic;digital;Doctor of Philosophy;Education;Ensure;epigenomics;Equipment;Ethnic Origin;Extramural Activities;Feedback;Formalin;Freezing;Frozen Sections;Funding;Future;Gender;Genomics;Health;high throughput analysis;Histology;Histopathology;human model;Human Resources;human tissue;Image;Image Analysis;Immune;Immunofluorescence Immunologic;Immunohistochemistry;Immunophenotyping;In Situ;innovation;instrumentation;Journals;Label;Laboratories;Leadership;Liquid substance;Malignant Neoplasms;Mass Spectrum Analysis;member;Meridians;metabolomics;MicroRNAs;Microscope;Microscopy;Microtomy;Molecular;Molecular Analysis;nano-string;NCI Center for Cancer Research;novel;Paper;Paraffin;Paraffin Embedding;Pathologic;Pathology;Patients;Peer Review;Pharmacology;Phenotype;Process;Production;programs;Proteomics;protocol development;Protocols documentation;Publications;Publishing;Race;Recommendation;recruit;repository;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;response;Saliva;sample collection;Sampling;Scanning;Services;Slide;Stains;success;Surveys;Therapeutic Research;Time;Tissue Banks;tissue culture;Tissue Embedding;tissue fixing;Tissue Microarray;Tissue Model;tissue processing;Tissues;tool;Training;translational cancer research;Translational Research;Translations;tumor;Universities;Urine;Work

PROJECT_TITLE: Histopathology & Tissue Shared Resource


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: WASHINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PI_NAMEs: CHEEMA, AMRITA KAUR (contact)

PROJECT_TERMS: 3-Dimensional;Acetylation;Advisory Committees;Aggressive behavior;anti-cancer research;arm;Basic Science;Bioinformatics Shared Resource;bioinformatics tool;Biological Assay;Biology;biomarker validation;Biometry;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cells;Cellular biology;Clinical;Clinical Drug Development;Clinical Sciences;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computer software;cost effective;Cytometry;data access;data acquisition;Data Analyses;Development;Disease;Doctor of Philosophy;drug development;Drug Kinetics;Educational workshop;Ensure;Experimental Designs;extracellular;Extramural Activities;Faculty;Funding;Genus Hippocampus;graduate student;Grant;Image;Immune;Individual;industry partner;Infrastructure;Institution;instrument;instrumentation;interest;Internships;Investigation;Investments;Journals;Label;laboratory experience;Laboratory Research;laser capture microdissection;Learning;lipidomics;Lipids;Malignant Neoplasms;Maryland;mass spectrometric imaging;Mass Spectrum Analysis;member;Mentors;Metabolic;metabolome;metabolomics;method development;Methods;Modeling;molecular imaging;molecular phenotype;Molecular Profiling;multiple omics;multiple reaction monitoring;multiplexed imaging;NCI Center for Cancer Research;novel;Oncology;Organizational Models;Organoids;Pathway Analysis;Pathway interactions;Peer Review;Peptides;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;Pharmacology Shared Resource;Phosphorylation;Polysaccharides;Population Sciences;Post-Translational Protein Processing;pre-clinical;Preparation;programs;protein biomarkers;Proteins;Proteomics;Publications;Research;Research Personnel;Resource Sharing;Respiration;Running;Sampling;Science;Services;Site;small molecule;spheroids;Strategic Planning;Students;success;Support System;Surveys;System;Systems Biology;Technical Expertise;Techniques;Technology;therapy resistant;Time;Tissues;tool;Training;Training Activity;training opportunity;Translational Research;Treatment Efficacy;tumor microenvironment;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Mass Spectrometry and Analytical Pharmacology Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: HADDAD, BASSEM R (contact)

PROJECT_TERMS: Advisory Committees;Aliquot;American Type Culture Collection;B-Lymphocytes;Basic Science;biobank;Biological Specimen Banks;Blood;Brain;Breast;cancer cell;Cancer cell line;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer prevention;cell bank;Cell Culture Techniques;Cell Line;Cell Reprogramming;cell transformation;Cellular biology;Characteristics;Clinical Trials;cloud based;Collaborations;Collection;Colon;Comprehensive Cancer Center;Data Collection;Databases;Development;Enrollment;Ensure;Epithelial Cells;established cell line;experience;Extramural Activities;Freezing;Funding;Genetic study;genomic locus;German population;Guidelines;Human;Human Herpesvirus 4;Individual;International;Journals;Kidney;Laboratories;Laboratory culture;Leadership;Lung;Malignant Neoplasms;Management Information Systems;member;Mission;Molecular;Monitor;Mus;Mycoplasma;NCI Center for Cancer Research;Nucleic Acids;Oncogenes;Organ;Peer Review;Peripheral Blood Mononuclear Cell;Plasma;Play;Process;programs;Property;Protocols documentation;Publications;Publishing;Quality Control;Rattus;Reagent;recruit;repository;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Role;Secure;Serum;Services;Specimen;Specimen Handling;Standardization;Students;success;Support System;Surveys;System;Testing;testing services;tissue culture;Tissue Microarray;Tissues;Training;Translational Research;Universities;Work

PROJECT_TITLE: Tissue Culture and Biobanking Shared Resource


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: MCGUIRE, COLLEEN J (contact)

PROJECT_TERMS: Adoption;Advisory Committees;Basic Science;Behavioral;biobank;cancer cell;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;Caring;Cellular biology;Clinic;Clinical;Clinical Cancer Center;Clinical Data;Clinical Nursing Research;Clinical Oncology;Clinical Protocols;Clinical Sciences;Clinical Trials;Collection;Complement;Comprehensive Cancer Center;Consent;cost effective;cost effectiveness;Critiques;Data;data cleaning;Data Collection;data management;Data Set;data standards;database design;Databases;design;Development;Discipline;Discipline of Nursing;Doctor of Philosophy;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Epidemiologist;experience;Extramural Activities;Feedback;Funding;Future;Goals;Health Services;Hereditary Malignant Neoplasm;Histopathology;Hospitals;Infrastructure;Intervention Studies;Leadership;Liquid substance;Malignant Neoplasms;Medical;member;NCI Center for Cancer Research;neoplasm registry;Nurse Administrator;Observational Study;Participant;participant enrollment;patient oriented;patient registry;Patients;Peer Review;Persons;Population Sciences;Population Study;Preparation;Prevention;Process;programs;prospective;Publications;Recontacts;recruit;Registries;Research;Research Personnel;Research Project Grants;Research Subjects;Research Support;Resource Sharing;Resources;response;Risk Assessment;Sampling;Science;Scientist;screening;Services;skills;sociodemographics;Study Subject;success;Surveys;synergism;Teacher Professional Development;Time;Tissue Culture Shared Resource;Tissues;tool;Training;Training and Education;translational scientist;Universities;University Hospitals;Update;Washington;web page;Work

PROJECT_TITLE: Survey, Recruitment, and Biospecimen Collection Shared Resource


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative In 2007, Massachusetts General (MGH) and McLean Hospitals piloted an integrated Research Concentration within the MGH/McLean Adult Psychiatry Residency Program to address the critical shortage of physician- scientists engaged in mental health research careers. This program has been highly successful in its goal of retaining MD/PhD trained physician-scientists and recruiting and developing new physician-scientists. This application will provide support and infrastructure to continue, improve, and expand this well-integrated research education program that serves to attract and train residents to become future psychiatrist-scientists in basic, translational, and patient-oriented research, while increasing research literacy among all residents.

PI_NAMEs: FAVA, MAURIZIO  (contact);LAGOMASINO, ISABEL TERESA;RESSLER, KERRY J.;SALVI, JOSHUA D

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Area;Basic Science;Benchmarking;Biomedical Research;career;career development;career life balance;catalyst;Center for Translational Science Activities;Clinical;Clinical Medicine;Clinical Sciences;Collaborations;college;Communities;Community Psychiatry;Competence;Dedications;design;Development Plans;Disabled Persons;disadvantaged background;Disparity population;diversity and inclusion;Doctor of Philosophy;education research;education resources;Educational Curriculum;Ethnic Origin;Ethnic Population;experience;Exposure to;Faculty;Fellowship;financial incentive;Formulation;Fostering;Funding;Future;gender disparity;gender minority health;General Hospitals;Genetic;Genomics;Goals;Graduate Degree;health disparity;Historically Black Colleges and Universities;Hospital Departments;Hospitals;improved;improved outcome;Individual;Infrastructure;innovation;Institution;interest;Intervention;Investments;Knowledge;Leadership;literacy;Massachusetts;medical schools;Medical Students;Medicine;meetings;Mental Health;Mentors;Mentorship;Methods;Mission;Monitor;Neurosciences;Outcome;Outcome Measure;patient oriented research;physician-scientist training program;Physicians;Play;Positioning Attribute;Process;process improvement;Program Evaluation;programs;Psychiatrist;Psychiatry;Public Health;Public Health Schools;Race;racial minority population;racial population;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;Residencies;Resources;response;Role;Science;Scientist;Sexual and Gender Minorities;sexual minority health;skills training;success;Talents;Time;Training;Training Programs;Translating;Translational Research;Universities;Woman;Work

PROJECT_TITLE: Fostering Research Mentorship and Training During Psychiatry Residency

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: The Yale Cancer Center Advanced Training Program for Physician-scientists (YCC-ATPP) is specifically designed to prepare YCC Hematology/Medical Oncology (Heme/MedOnc) fellows for independent careers as physician-scientists in cancer-related research. Through the program, T32 fellows receive essential training and support including protected research time, funding, dedicated mentorship from a three-member Mentor Team, research projects, individual development plans, didactic courses, opportunities to mentor students and residents in the summer Diversity Enhancement Program in Oncology, community outreach and engagement initiatives, as well as transitional pathways to facilitate the establishment of a solid foundation for their future careers as physician-scientists.

PI_NAMEs: HERBST, ROY S (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: physician-scientist training program;Yale Cancer Center

PROJECT_TITLE: Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT SUMMARY/ABSTRACT Accelerating the future development of new cancer treatments requires educating the next generation of leaders in this field in the complex interactions between tumors, their surroundings, and the immune system, and preparing them to efficiently conduct research in today's regulatory and administrative environment. The T32 Investigational Cancer Therapeutics Training Program (ICTTP) at Memorial Sloan Kettering Cancer Center addresses this need by providing fellows in medical oncology who are committed to careers in translational cancer research with comprehensive mentored research and didactic training for two years. The ICTTP program is designed to optimally train physician scientists to translate discoveries regarding the biology of cancer into new, approved molecular/cytotoxic, immunotherapeutic, and cell-based treatments through state-of-the-art experimental trials.

PI_NAMEs: ABDEL-WAHAB, OMAR ;DRILON, ALEXANDER  (contact);IYER, GOPA

PROGRAM_OFFICER_NAME: LIM, SUSAN E

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient-oriented and laboratory-based research in diabetes and endocrine disorders of children. This will address a major public health need which is the critical shortage of academic pediatric endocrinologists in diabetes and endocrinology research. The Program will support 3 Fellow Trainees per year for up to 2 years of mentored research training at the fellowship level working with NIH-funded Training faculty from the Children’s Hospital and the Perelman School of Medicine at University of Pennsylvania.

PI_NAMEs: KATZ, LORRAINE E LEVITT (contact);KELLY, ANDREA BRIDGET

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Childhood diabetes;Endocrinology;Research Training;Translational Research

PROJECT_TITLE: Translational Research Training in Pediatric Diabetes & Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: AMES

ORG_DEPT: GENETICS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: The central goal for this application is to provide CRISPR/Cas methods and resources for conditional gene studies and improved precision genome editing to enhance zebrafish animal models for biomedical research. We expect by the end of the funding period to significantly expand our Cre and conditional allele resource to established fields of zebrafish studies (embryonic development, major tissue and organ systems) as well as understudied, rapidly emerging areas (epigenetics, mitochondrial biology) to facilitate new zebrafish models of human health across the lifespan. Our methods to improve GeneWeld and DonorGuide precision genome editing in zebrafish will be widely applicable, given the near universal application of CRISPR genome editing in model and non-model systems.

PI_NAMEs: CLARK, KARL J;EKKER, STEPHEN CARL;ESSNER, JEFFREY J;MCGRAIL, MAURA A. (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Adult;Advertisements;Alleles;Animal Model;animal resource;Area;Biological Models;Biological Process;Biology;Biomedical Research;Blood Vessels;Body System;cell type;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Cre driver;CRISPR/Cas technology;design;Development;Developmental Process;Disease;disease model;DNA;DNA Repair Pathway;Embryo;embryo cell;Embryonic Development;Energy Metabolism;Engineering;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;epigenome;Fertility;Frequencies;Funding;Gene Expression;Gene Transfer Techniques;Generations;Genes;Genetic;genetic manipulation;Genetic Recombination;genetic resource;Genetic study;Genome;genome editing;Genome engineering;Genomics;Germ Layers;Goals;Health;Human;human model;Image;Immune system;improved;Individual;Injections;innovation;Integrase;Investigation;life span;LoxP-flanked allele;Mediating;Methods;Mission;Mitochondria;Modeling;Mus;Natural regeneration;novel;Nuclear;Nucleotides;Optics;Organ;outreach;Pathology;Postembryonic;Principal Investigator;Publishing;Reagent;Recording of previous events;Regulation;repair strategy;repaired;Reproducibility;Research;Resources;Skeletal system;Skin;social media;symposium;System;Technology;Testing;Tissue Model;tissue regeneration;Tissues;tool;Training;transgene expression;Transgenes;United States National Institutes of Health;Variant;virtual;Visualization;web site;Work;Zebrafish;zebrafish genome

PROJECT_TITLE: Conditional genetics and precision genome editing resources for Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: NARRATIVE The P01 proposal ExpLoiting thErapeutic VulnerAbilities in hepaTocEllular carcinoma (ELEVATE) aims to interrogate molecular mechanism of hepatocellular carcinoma (HCC) arising from obesity-induced non- alcoholic steatohepatitis (NASH) and evaluate a variety of combinatorial treatment options, based on underlying molecular abnormalities, using an authentic NASH-HCC mouse model. The studies will generate translationally relevant data from preclinical models having the potential to significantly impact the management of HCC patients, facilitating prolonged survival.

PI_NAMEs: SARKAR, DEVANAND  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: antagonist;anti-PD-1;anti-PD-L1;anti-PD1 antibodies;Antibodies;BAY 54-9085;bevacizumab;Bile Acids;Bioinformatics;Biology;Biometry;Bystander Effect;cancer immunotherapy;Cell Compartmentation;Clinical;combinatorial;cytokine;Data;Development;Diagnosis;Diet;Drug resistance;effective therapy;Evaluation;Exhibits;Fatty acid glycerol esters;FDA approved;Gene Amplification;Genetic Determinism;Genetic Transcription;Goals;Grant;Growth;Hepatocyte;Hepatology;Human;Immune checkpoint inhibitor;Immune system;Immunologic Stimulation;Immunologic Surveillance;Immunotherapy;improved;in vivo;Incidence;Inflammatory;inhibitor;innovation;Interleukin-15;Interleukin-24;Liver;liver cancer model;Lung Neoplasms;Malignant Neoplasms;Modality;Molecular;Molecular Abnormality;Monoclonal Antibodies;mouse model;Mus;MYC gene;Myeloid Cells;nanoparticle;nanoparticle delivery;Natural Killer Cells;nonalcoholic steatohepatitis;novel;novel strategies;novel therapeutics;Obesity;Outcome;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Chemistry;Physiology;Play;Pre-Clinical Model;Predisposition;Primary carcinoma of the liver cells;programs;Prostatic Neoplasms;prototype;Recording of previous events;Resistance;response;Risk;Role;scavenger receptor;Seminal;Signal Transduction;Small Interfering RNA;Sphingosine-1-Phosphate Receptor;standard of care;sugar;Systemic Therapy;targeted delivery;targeted treatment;TATA-Binding Protein Associated Factors;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy development;Treatment Efficacy;tumor;Tyrosine Kinase Inhibitor;Unresectable;Vaccines;Viral hepatitis;Wages

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (J1)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

PHR: CORE 1 – ADMINISTRATIVE CORE: NARRATIVE Core 1 will provide critical support to ensure the seamless integration and effective planning and management of the ELEVATE program. The core will oversee the overall research direction and fiscal management, ensuring accountability and compliance with all institutional, state, and federal requirements for grants management and resource sharing, to ensure that the program goals are met.

PROJECT_TERMS: Accountability;Advisory Committees;Applications Grants;Bioinformatics;Biometry;cancer immunotherapy;Collaborations;Communication;Complex;data sharing;Diagnosis;Ensure;Evaluation;experience;follow-up;gene function;Goals;Grant;Institution;inter-institutional;Judgment;Knowledge;Leadership;Massey Cancer Center at the Virginia Commonwealth University;meetings;Molecular;mouse model;nanoparticle;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathologic;Pharmaceutical Chemistry;Phase I/II Clinical Trial;Pre-Clinical Model;Primary carcinoma of the liver cells;Program Research Project Grants;programs;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Science;Secure;Structure;symposium;Therapeutic;Tissue Sample;treatment response;tumorigenesis;Virginia;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PHR: PROJECT 1: NARRATIVE Nonalcoholic fatty liver disease (NAFLD), especially its aggressive form, nonalcoholic steatohepatitis (NASH), is a leading cause of cirrhosis and hepatocellular cancer (HCC). The I148M variant of the patatin-like phospholipase A-3 (PNPLA3) gene is one of the best-described genetic determinants of HCC risk across multiple etiologies of chronic liver disease, including NAFLD; however, the mechanisms by which PNPLA3I148M leads to HCC are poorly understood. The focus of this application is to examine the role of the PNPLA3I148M variant in promoting HCC development and further identify the underlying mechanisms for developing potential therapies.

PI_NAMEs: SANYAL, ARUN J (contact)

PROJECT_TERMS: Acceleration;Animal Model;antagonist;Automobile Driving;Bile Acids;Biological Markers;Cancer Etiology;cancer predisposition;cancer risk;cholangiocyte;chronic liver disease;Cirrhosis;Collaborations;Complex;Data;Development;diagnostic strategy;Diet;Disease Progression;Etiology;Evolution;Feedback;Fibrosis;Future;gain of function;Genes;Genetic;Genetic Determinism;glucose metabolism;Goals;Health;Hepatic;Hepatocyte;High Prevalence;Hispanic Populations;Histologic;Homeostasis;Human;In Vitro;in vivo;Inflammation;inhibitor;Injections;insight;Knock-out;Knowledge;Link;lipid metabolism;Liver;Liver Fibrosis;loss of function;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Methods;Mission;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Oncogenes;overexpression;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phospholipase;Phospholipases A;Play;Population;Prevention strategy;Preventive;Primary carcinoma of the liver cells;programs;prototype;Publications;Publishing;Reagent;receptor;Research Personnel;Risk;Role;Signal Transduction;Signaling Molecule;Sphingosine-1-Phosphate Receptor;Taurocholic Acid;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Translating;treatment strategy;tumor-immune system interactions;United States National Institutes of Health;Up-Regulation;Variant

PROJECT_TITLE: Bile Acid-Mediated Signaling In HCC


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

PHR: PROJECT 2: NARRATIVE The proposed studies will interrogate the mechanism by which two co-amplified genes, MYC and TAF2, cooperate to promote hepatocellular carcinoma (HCC) development and progression and evaluate therapeutic efficacy of combined inhibition of MYC and TAF2 along with immune checkpoint inhibitors in endogenous mouse models of HCC.

PROJECT_TERMS: Affect;Allografting;anti-PD-1;anti-PD-L1;anti-PD1 antibodies;Antibodies;bevacizumab;ChIP-seq;Chromosomes;Co-Immunoprecipitations;cofactor;combinatorial;Complex;Data Analyses;Databases;Death Rate;Development;Diet;Diethylnitrosamine;Disease;effective therapy;Event;Fatty acid glycerol esters;FDA approved;Gene Amplification;Gene Expression;Gene Expression Regulation;Genes;Genetic Determinism;Genetic Transcription;Global Change;Goals;Hepatocarcinogenesis;Hepatocyte;Human;Immune checkpoint inhibitor;Immunologics;Immunotherapy;Incidence;inhibitor;Injections;innovation;Invaded;knock-down;Knock-out;Knockout Mice;Liver;liver cancer model;Liver diseases;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;migration;Molecular;mortality;mouse model;Mus;MYC Box;MYC gene;nanoparticle delivery;neoplastic cell;nonalcoholic steatohepatitis;novel;Obesity;oncogene addiction;Oncogenes;overexpression;Patients;Play;Predisposition;Primary carcinoma of the liver cells;Process;recruit;response;Risk;RNA Interference;Role;single cell ATAC-seq;single-cell RNA sequencing;Sleeping Beauty;Small Interfering RNA;sugar;Tail;targeted treatment;TATA-Binding Protein Associated Factors;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutically effective;transcription factor;Transcription Factor TFIID;transcriptome sequencing;Transposase;Treatment Efficacy;treatment strategy;tumor;Veins

PROJECT_TITLE: Cooperation of Co-Amplified Genes in Hepatocellular Carcinoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Hematology;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

PHR: PROJECT 3: NARRATIVE This project addresses a novel innate pattern recognition receptor (i.e., SRA/CD204) in the tumor microenvironment that can impede immune surveillance and promote therapeutic resistance of hepatocellular carcinoma (HCC). By gaining an in-depth understanding of the underlying mechanism of SRA function in these processes and successfully testing blocking antibodies targeting this receptor in preclinical models, we can significantly advance the current treatment options for HCC.

PI_NAMEs: WANG, XIANG-YANG SHAWN (contact)

PROJECT_TERMS: Ablation;Address;anti-PD-1;anti-PD1 therapy;Antibodies;BAY 54-9085;Bioinformatics;Biological;Biological Process;Blocking Antibodies;cancer cell;cancer immunotherapy;Cell Compartmentation;Cell Shape;cell stroma;cell type;Cells;checkpoint therapy;Clinical;Collaborations;conditional knockout;Data;Dendritic Cells;Disease Progression;drug development;Environment;exhaustion;Exhibits;Genomics;Goals;Growth;Hepatocarcinogenesis;Homeostasis;Host Defense;Human;Hybridomas;Immune;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune Tolerance;Immunologic Surveillance;Immunologics;Immunotherapeutic agent;Immunotherapy;Impairment;improved;Infiltration;inhibitor therapy;innovation;Invaded;Knockout Mice;Knowledge;Leukocytes;Liver;liver cancer model;Macrophage;Malignant Neoplasms;Mediating;Modality;Modeling;Molecular;molecular targeted therapies;Monoclonal Antibodies;monocyte;mouse model;Mus;MYC gene;Myelogenous;Myeloid Cells;novel;novel strategies;optimal treatments;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern recognition receptor;Pre-Clinical Model;Predisposition;Primary carcinoma of the liver cells;Process;programmed cell death protein 1;programs;Proto-Oncogene Proteins c-myc;receptor;Receptor Cell;Regimen;Research;Resistance;response;Role;scavenger receptor;success;System;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;therapeutic development;Therapeutic Uses;therapy resistant;Tissues;tool;Treatment outcome;tumor;Tumor Escape;tumor microenvironment;tumor progression;tumor-immune system interactions;Validation

PROJECT_TITLE: A Novel Target in The Tumor Myeloid Compartment for Hepatocellular Carcinoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

PHR: PROJECT 4: NARRATIVE Hepatocellular carcinoma (HCC) is associated with significant morbidity without a currently effective therapy. We describe a novel molecular reagent, a Fusion Superkine, and an innovative delivery approach permitting safe and efficient targeted systemic administration of therapeutic agents, including viruses, that employs microbubbles and focused ultrasound to release therapeutic agents in the liver. The novel reagent and innovative strategies we have developed, including an effective combinatorial regimen, have the capacity to transform and enhance the clinical management of HCC.

PI_NAMEs: FISHER, PAUL B (contact)

PROJECT_TERMS: Address;Adenoviruses;Advanced Malignant Neoplasm;Affect;Angiogenesis Inhibition;Animal Model;anti-cancer;antiangiogenesis therapy;Antibody Therapy;anticancer activity;Autophagocytosis;BAY 54-9085;Biological;biomarker development;cancer cell;Cell Maintenance;Cell Proliferation;Cell Therapy;Cells;chemotherapy;Chimeric Proteins;Clinical;Clinical Management;combinatorial;conventional therapy;cytokine;cytokine therapy;cytotoxicity;Data;Death Rate;Development;Diet;Disease;Disease Progression;Disseminated Malignant Neoplasm;Distant;Drug Combinations;Ectopic Expression;effective therapy;efficacy evaluation;Engineering;experimental study;Family member;Focused Ultrasound;Future;Genetic;Genetic Engineering;Goals;Growth;IL10 gene;Immune;immune clearance;Immune response;Immune system;Immunologic Stimulation;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Individual;Induction of Apoptosis;innovation;Interleukin-15;Interleukin-24;Interleukins;Investigational Drugs;Laboratories;Liver;Liver neoplasms;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Methodology;Microbubbles;Modality;Molecular;Molecular Medicine;Molecular Target;molecular targeted therapies;Monitor;Morbidity - disease rate;mouse model;multiple drug use;Myelogenous;Myeloid Cells;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;next generation;nonalcoholic steatohepatitis;novel;Patients;Permeability;Phase I Clinical Trials;phase I trial;pre-clinical;prevent;Prevention;Primary carcinoma of the liver cells;programs;Property;Protein Secretion;Proteins;Protocols documentation;Publications;Radiation;Radiation therapy;Reagent;Recurrence;Recurrent tumor;Regimen;Research;research clinical testing;Research Personnel;Resistance;Role;Safety;Scheme;Serotyping;Site;skills;standard of care;Stat5 protein;synergism;targeted cancer therapy;targeted delivery;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;therapy outcome;translational potential;treatment response;tumor;Tumor Immunity;tumor microenvironment;ultrasound;Vaccines;Virus

PROJECT_TITLE: Designer Cytokine Therapy of Hepatocellular Carcinoma


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases

PHR: CORE 2 - MOUSE MODELS AND PATHOLOGICAL ANALYSIS CORE: NARRATIVE Core 2 will support the research of the ELEVATE program projects by 1) generating and providing experimental mice of four different hepatocellular carcinoma (HCC) models, 2) providing access to human HCC tumor specimens and patient blood samples, and 3) providing pathological analysis of both human and mouse tumor specimens.

PI_NAMEs: WINDLE, JOLENE J (contact)

PROJECT_TERMS: Age;Animal Experiments;Animals;biobank;Blood specimen;Breeding;Cancer Center;Cancer Model;carcinogenesis;Clinical;Collaborations;Collection;Data;data acquisition;Data Analyses;Development;Diet;Ensure;Fatty acid glycerol esters;Formalin;Freezing;Gene Modified;Goals;hepatocellular carcinoma cell line;Human;Injections;intrahepatic;Knock-out;Knockout Mice;Liver;liver cancer model;male;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Oncogenes;Operative Surgical Procedures;Paraffin Embedding;Pathologic;Pathology;Patients;Plasmids;Primary carcinoma of the liver cells;Production;Program Research Project Grants;programs;pup;Reagent;Regimen;Reproducibility;Reproducibility of Results;Research;Research Personnel;Research Support;Resources;response;Sampling;Science;Services;Sleeping Beauty;Specimen;sugar;Tail;Technical Degree;Technical Expertise;Therapeutic;Time;Tissues;Transgenic Organisms;Translational Research;Transposase;treatment response;tumor;Tumor Tissue;tumorigenesis;Universities;Veins;Virginia;western diet

PROJECT_TITLE: Mouse Model and Pathological Analysis Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Rare Diseases

PHR: CORE 3 - BIOSTATISTICS AND BIOINFORMATICS CORE: NARRATIVE The Biostatistics and Bioinformatics Core (Core 3) will provide dedicated expertise and cost-efficient support in biostatistics, bioinformatics, and research data management for the ELEVATE Program Project Grant P01 application. This core is critical for the ELEVATE program to achieve its overarching research goals of 1) interrogating molecular mechanisms regulating non-alcoholic steatohepatitis (NASH)-hepatocellular carcinoma (HCC) and development of novel combinatorial treatment approaches based on the identified molecular abnormalities, 2) evaluating approaches that improve the efficacy of approved immunotherapy using an authentic NASH-HCC mouse model, and 3) developing novel approaches that engage the immune system to counteract HCC.

PI_NAMEs: WAGES, NOLAN  (contact)

PROJECT_TERMS: Address;Adherence;anti-cancer research;Applications Grants;Basic Science;Bioinformatics;Biomedical Research;Biometry;Cancer Biology;Clinical;Collaborations;combinatorial;Communities;Consult;Consultations;Core Facility;cost efficient;Data;Data Analyses;Data Collection;data management;data quality;Data Set;data sharing;Dedications;design;Development;Documentation;Ensure;Experimental Designs;experimental study;Faculty;Formulation;genomic data;Genomics;Goals;high throughput analysis;High-Throughput Nucleotide Sequencing;Human Resources;Immune system;Immunotherapy;improved;Information Dissemination;interoperability;Laboratories;Licensing;Manuscripts;Methodology;Mission;Molecular;Molecular Abnormality;mouse model;nonalcoholic steatohepatitis;novel;novel strategies;Pathologic;Pathology;pre-clinical;Preparation;Primary carcinoma of the liver cells;Program Research Project Grants;programs;Publications;quality assurance;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Personnel;research study;Research Support;Sample Size;software development;sound;Specific qualifier value;Statistical Data Interpretation;statistics;Therapeutic;therapeutically effective;Translational Research;usability

PROJECT_TITLE: Biostatistics and Bioinformatics Core (BBC)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Multiple-X-ray Source Array-based ComputedTomography (MXA-CT) Narrative We propose the development of a brand-new type of x-ray tube which uses six or more sources of radiation (sometimes simultaneously), and to use this new x-ray source to develop a faster computed tomography scanner with much better image quality than existing systems. The multi x-ray source array (MXA) is likely to revolutionize CT imaging, for standard whole body CT systems and so-called cone beam CT systems which are specially built for dental, knee, breast, and other imaging applications.

PI_NAMEs: BOONE, JOHN M (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Multiple X-ray Source Array (MXA) Computed Tomography

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Pain Research;Sexually Transmitted Infections

ORG_CITY: PRINCESS ANNE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND EASTERN SHORE

ORG_STATE: MD

PHR: PPROJECT NARRATIVE Herpes simplex viruses (HSV) can infect human causing severe neurological damage and painful orofacial complications. We will use an innovative method to study the molecular mode of action of HSV infection of neurons. Success of this proposal will set the basis for a better understanding of racial and gender disparities post viral infection.

PI_NAMEs: HSIA, SHAOCHUNG VICTOR (contact)

PROGRAM_OFFICER_NAME: PARK OCHSNER, SUSAN SOO

PROJECT_TERMS: Acute;acute infection;Acute Pain;Acyclovir;Afferent Neurons;assault;Brain;Calcium Channel;Cell Culture Techniques;Cells;Chromatin;Chronic;chronic pain;Clinical;Data;differential expression;drug candidate;Drug Targeting;Economics;Emotional;Encephalitis;Environment;Epigenetic Process;Epithelial Cells;Esthesia;Exhibits;gender disparity;Gene Expression;Gene Silencing;Gene Structure;Genes;Genetic Transcription;Goals;Health;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Hour;Human;human model;Immediate-Early Genes;In Vitro;Infection;inhibitor;innovation;interest;Interleukin-6;latency associated transcript;Life Cycle Stages;Maintenance;Mediating;Membrane;Methods;MicroRNAs;Modeling;Modification;Molecular;Molecular Profiling;Mus;Nerve;Nervous System Trauma;Neuroglia;neuronal excitability;Neurons;Neuropathy;Nociceptors;orofacial;Oryctolagus cuniculus;overexpression;Pain;Pathogenesis;Patients;Phase;Physiological;Physiology;Play;Postherpetic neuralgia;prevent;Probability;promoter;prospective;Proteomics;Publications;racial disparity;reactivation from latency;Regulation;Repression;Rodent;Rodent Model;Role;Scheme;Simplexvirus;Sodium Channel;Spinal Ganglia;Stress;stressor;Structure of trigeminal ganglion;Study models;success;Time;TNF gene;Trans-Activators;transcriptomics;Untranslated RNA;Viral;Viral Genes;viral RNA;Virus;Virus Diseases;Virus Latency;Virus Replication;voltage;voltage gated channel;VP 16

PROJECT_TITLE: Cross-talk of Neurons and HSV-1 during Viral Latency and Reactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MMO-D (J1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE The Training Program at the Interface of Reproductive Sciences and Bioengineering proposes to train predoctoral students to conduct innovative and high-quality research at the forefront of reproductive biology. This unique educational platform will expose trainees to cutting-edge and emerging technologies that can advance progress in reproductive research, and train them to meet the challenges required to succeed in any professional environment such as academia, industry, or government.

PI_NAMEs: BAGCHI, INDRANI C (contact);WAGONER JOHNSON, AMY J

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Biomedical Engineering;Interdisciplinary Study;Reproductive Sciences;Research Training

PROJECT_TITLE: Interdisciplinary Research Training at the Interface of Reproductive Sciences and Bioengineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: NARRATIVE The UC Davis enhanced Molecular, Cellular, and Developmental Biology (eMCDB) Training Program will provide high quality predoctoral training to its diverse Trainees and prepare them for impactful careers in the biomedical workforce. This will be accomplished by a coherent set of enhanced training activities aimed at nurturing productive, rigorous, resilient scientists and confident communicators.

PI_NAMEs: CHEDIN, FREDERIC LOUIS (contact);DIAZ, ELVA D

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Cellular biology;Developmental Biology;Molecular Biology;Training Programs

PROJECT_TITLE: The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Infectious Diseases;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Individuals who identify as African American, Hispanic/Latino/a/x, Native American, and/or Pacific Islanders comprise approximately 39% of the college population but earn only 13% of doctoral degrees in the life sciences and constitute only 13% of recent medical graduates and 7.3% of full-time medical faculty. The objective of the proposed INfectious Diseases Summer Research Program Integrating Research at Emory (INSPIRE) training program at Emory University is to prepare 48 underrepresented undergraduate students from throughout the country for a career in infectious diseases research by implementing a 10-week summer research experience, delivering courses for professional and research skills development, and establishing a mentorship program that directly addresses identity and underrepresentation. At the same time and in preparation, the program will strengthen the capacity of the institution to mentor underrepresented trainees by conducting workshops in mentoring and facilitation for 75 post-doctoral fellows and junior faculty who are underrepresented and 87 faculty who are research and identity mentors.

PI_NAMEs: CHUNG, MICHAEL HOONBAE (contact);CORBETT, ANITA H.;WILEY , ZANTHIA

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;African American;African American population;Behavioral Research;Behavioral Sciences;Biological Sciences;Biomedical Research;career;Clinic;Clinical;Clinical Research;college;Communicable Diseases;Communities;Country;COVID-19 vaccination;Creativeness;Cultural Backgrounds;Data;Dedications;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;Educational workshop;Equipment;equity, diversity, and inclusion;ethnic diversity;Ethnic Origin;Exclusion;experience;experimental study;Faculty;faculty mentor;field study;Fostering;Goals;graduate school;graduate student;hands on research;Health;health care delivery;Health system;Healthcare;Hispanic;Historically Black Colleges and Universities;improved;Individual;Infectious Diseases Research;innovation;institutional capacity;Intervention;Investments;Laboratories;Latina;Latino;Latinx;Lead;Medical;Medical Faculty;medical schools;Medical Students;Medicine;meetings;member;Mentors;Mentorship;Mission;National Institute of Allergy and Infectious Disease;Native Americans;online course;Output;Pacific Islander;Pathway interactions;Persons;Population;Positioning Attribute;Postdoctoral Fellow;posters;Preparation;programs;Public Health;public trust;Race;racial discrimination;recruit;Reduce health disparities;Research;research and development;research faculty;Research Personnel;Research Training;Resources;Schools;Science;Site;skill acquisition;skills;STEM field;STEM research;Students;summer program;summer research;symposium;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;vaccine acceptance;Vocational Guidance;Voice

PROJECT_TITLE: INfectious Diseases Summer Program Integrating Research at Emory (INSPIRE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 TC-D (J1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The ENGAGED program takes advantage of the broad, multidisciplinary research established in the area of aging at Wake Forest University School of Medicine and our partner institutions, Wake Forest University and Winston-Salem State University. ENGAGED provides undergraduate students who are under-represented (UR) in careers in the biomedical sciences (BMS) an opportunity to participate in educational and research training in the field of gerontology/geriatrics. The overall goal is to advance diversity in research in aging and the health disparities of aging, specifically, and in BMS research, in general, by creating career pathways for well-trained UR students interested in biomedical, behavioral, and clinical research careers.

PI_NAMEs: BRINKLEY, TINA E (contact);GWATHMEY, TANYA M.

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Achievement;Address;Aging;aging population;aging related;Alzheimer disease prevention;Appointment;Area;Attention;Awareness;Bachelor's Degree;Behavioral Research;Biomedical Research;biomedical scientist;Cardiovascular Diseases;career;Career Choice;Clinic;Clinical;Clinical Research;Collaborations;Communities;comorbidity;Degree Completion;Degree program;Dementia;Development;Diabetes Mellitus;Disease;Doctor of Philosophy;Education;Educational workshop;Elderly;Elements;Engineering;experience;Exposure to;Faculty;field trip;Fostering;Foundations;frailty;Funding;Future;Geriatrics;Gerontology;Geroscience;Goals;Health;Health Disparities Research;health disparity;Health Professional;Health Sciences;Healthcare;healthy aging;Individual;Institution;Interdisciplinary Study;interest;Internships;Journals;Knowledge;lectures;Mathematics;Measurable;medical schools;Medicine;meetings;member;Mentors;Mobility disability;next generation;Obesity;Oral;Outcome;Participant;Persons;Population;Positioning Attribute;posters;pre-clinical;Professional counselor;Program Evaluation;programs;Progress Reports;Publications;Publishing;Recording of previous events;Research;Research Personnel;Research Training;Resources;Science;Science, Technology, Engineering and Mathematics;Scientist;Seasons;Site;skill acquisition;Solid;Student recruitment;success;summer internship;summer program;summer research;summer student;Syndrome;Teacher Professional Development;Technology;tool;Training;Training and Education;Training Programs;translational pipeline;Translational Research;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;university student;Update;virtual

PROJECT_TITLE: Enhancing UNderGraduate Education and Research in AGing to Eliminate Health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (J2)]


NIH_SPENDING_CATS: Aging;Social Determinants of Health

PHR: Project Narrative Pipeline for Aging Research Career Training (PACT) is a training and career building program for underserved undergraduate students. Our institution has a number of aging research related NIH funded training programs that the participants consider. The program will have significant elements of lab skill training, mentored research, evaluation, and career coaching.

PI_NAMEs: BLANCATO, JAN K (contact);LI, P. ANDY

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Academic Medical Centers;Active Learning;Address;Adult;Affect;Aging;aging related;Alzheimer's Disease;Area;Arthritis;Awareness;Biological Sciences;Biomedical Research;career;Career Choice;career development;career networking;cell type;Chronic;Coffee;college;Communication;community building;Competence;Creativeness;design;Development;Diabetes Mellitus;Discipline;Disease;District of Columbia;Education Projects;education research;Educational Activities;Elements;Equity;ethnic disparity;ethnic minority;Evaluation;experience;Exposure to;Faculty;Funding;Future;Geroscience;Goals;graduate school;Health;health disparity populations;health equity;Healthcare;Heart Diseases;Historically Black Colleges and Universities;human old age (65+);Hypertension;improved;Individual;Industry;Informatics;Institution;Laboratories;laboratory experience;Learning;lectures;Location;Low income;Malignant Neoplasms;Measures;Mental Depression;Mentors;Mentorship;Minority;minority student;minority undergraduate;Minority-Serving Institution;molecular marker;Motivation;Nonprofit Organizations;North Carolina;Occupations;Participant;Personal Growth;Persons;Policies;Postdoctoral Fellow;posters;pre-doctoral;Prevention;programs;racial disparity;racial minority;Reagent;Research;Research Activity;Research Design;research in practice;Research Personnel;Research Project Grants;Research Training;Role;Science;Scientist;Series;Site;skill acquisition;skills;skills training;Source;Specialist;Speed;Structure;student participation;Students;success;Techniques;Terminology;tool;Training;Training and Education;training opportunity;Training Programs;trend;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved students;United States National Institutes of Health;Universities;virtual;Vocabulary;Washington

PROJECT_TITLE: Pipeline in Aging Research Career Training (PACT)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative: Alcohol misuse is a significant public health concern. This training grant draws from multiple disciplines to prepare postdoctoral fellows to investigate biological, behavioral, psychological, and social mechanisms that underlie alcohol misuse and its treatment. It sets clear and objective standards to assist fellows in successfully achieving a career in alcohol research, encourages professional development and networking opportunities, and emphasizes health disparities and social determinants of health, data science, social media research, and mobile technologies.

PI_NAMEs: ALESSI, SHEILA MARIE (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TITLE: Postdoctoral Training Program in Alcohol Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (32)]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE CD4+ T cells from Cftr deficient mice have recently been shown to have increased CD4+ Th2 cytokine production, and our preliminary studies suggest CFTR may function as a GATA3 responsive negative regulator of CD4+ Th2 polarization and effector function. In this proposal, we will use CD4+ T cells from mice and humans, a murine in vivo allergen model of Th2 inflammation, and electronic health record data to investigate the mechanisms of CFTR in Th2 inflammation and test whether CFTR modulation can reduce allergic inflammation.

PI_NAMEs: COOK, DANIEL PAUL (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;airborne allergen;Airway Disease;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic Bronchopulmonary Aspergillosis;Allergic Disease;Allergic inflammation;Alternaria;Animal Model;Anions;antagonist;Asthma;Attenuated;Award;Bacterial Artificial Chromosomes;Bicarbonates;Binding;Biological Markers;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;Child;Chronic;Clinical;Clinical Research;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Computer Analysis;Computerized Medical Record;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Cytokine Gene;Data;Development;Disease;Electronic Health Record;eosinophil;experimental study;FDA approved;Flow Cytometry;GATA3 gene;gene repression;General Population;Genes;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Hemostatic Agents;Human;IgE;Immunologist;Immunology;In Vitro;in vivo;Inbred CFTR Mice;Inflammation;Inflammatory;Inflammatory Response;Interleukin-13;Interleukin-4;Interleukin-5;knowledgebase;Laboratory Study;large datasets;Lung;Maintenance;Mediating;Modeling;mortality risk;mouse model;Mucous Membrane;Mus;mutant;Mutation;novel;novel therapeutic intervention;overexpression;Pathogenesis;pathogenic bacteria;pathogenic fungus;Patients;Persons;Phenotype;Physicians;Prevalence;Production;promoter;Proteins;Regulation;Regulatory Element;Repression;Respiratory Disease;response;Role;Scientist;Serum;Signal Transduction;small molecule;T-Cell Activation;T-Lymphocyte;Technology;Testing;Thyroid Hormone Receptor Beta;Tissues;Training;Transgenic Mice;VX-770

PROJECT_TITLE: Inhibiting CD4+ Th2 development and function by CFTR activity.

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative Communication disorders affect millions of individuals, with significant impacts in terms of disability and quality of life. The development of assessment and treatment strategies for these disorders requires that the next generation of researchers understand the mechanisms underlying these communication disorders; however, progress has been hampered by a shortage of clinically-knowledgeable communication scientists with the methodological skills required to study these underlying mechanisms. The current training plan seeks to prepare predoctoral and postdoctoral trainees studying the cognitive neuroscience of communication by supplying them with the necessary methodological expertise and tools to conduct and disseminate impactful research on communication disorders while making meaningful connections between trainees and the clinical populations they study.

PI_NAMEs: EIGSTI, INGE-MARIE ;MYERS, EMILY B (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Training in the Cognitive Neuroscience of Communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (11)]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative While digestive diseases continue to affect over 60 million people, causing nearly a quarter million deaths per year at a cost of over $135 billion, there remains a shortage of physician-scientists in the field who can identify new strategies for treatment and prevention. Our T32 program at Columbia trains physicians in the design and execution of high-quality, clinically relevant research in digestive and liver diseases, and we seek to continue our highly successful program in preparing future physician-scientists in the GI field.

PI_NAMEs: WANG, TIMOTHY CRAGIN (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Multidisciplinary Training in Translational Gastrointestinal and Liver Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Many scientific challenges in biomedicine require understanding of how biological processes at the molecular scale give rise to functions at the levels of whole body. This interdisciplinary training program trains a pre-doctoral students apply modern technologies to these multiscale challenges.

PI_NAMEs: MCCULLOCH, ANDREW D. (contact);RANGAMANI, PADMINI

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Biological;Structure;Training

PROJECT_TITLE: Training in Multi-scale Analysis of Biological Structure and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (J1)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Biofabrication merges materials science processing with controlled cellular behavior, with impacts on fields such as tissue engineering and regenerative medicine, drug delivery, three-dimensional cell culture, and in vitro tissue models. To further impact these fields and to educate a future workforce, new training programs are needed that not only educate in quantitative fundamentals and biofabrication techniques, but also drive the intersection of basic research and commercialization. Through our innovative training program, including a biofabrication course, industry exposure, co-mentorship to harness the expertise of Preceptors, and a bi-weekly seminar series, our Trainees will be poised to make a meaningful impact on society through biomedicine.

PI_NAMEs: BRYANT, STEPHANIE J (contact);BURDICK, JASON A

PROJECT_TERMS: biofabrication;Training Programs

PROJECT_TITLE: Biofabrication Training Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Autoimmune rheumatic diseases are a major cause of morbidity and mortality. Defining pathophysiologic mechanisms, recognizing disease phenotypes and trajectories, identifying risk factors, and directing interventional and prevention programs requires a cadre of well-trained investigators in rheumatic diseases. Our goal is to provide training to highly qualified individuals who will become the future leaders in academic rheumatology.

PI_NAMEs: BINGHAM, CLIFTON O (contact);CASCIOLA-ROSEN, LIVIA A

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Multidisciplinary Rheumatology Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Mental Health;Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This program trains MDs, MD/PhDs, and PhDs for careers as independent researchers. A program didactics and execution of research is described. Fellows learn to identify research questions, formulate hypotheses, and design and execute experiments to test those hypotheses.

PI_NAMEs: LEONARDO, EDUARDO DAVID (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Animal Model;Anxiety Disorders;Mood Disorders;Patients;Research Training

PROJECT_TITLE: Research Training in Mood and Anxiety Disorders: From Animal Models to Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative The Neuroimaging Sciences Training Program (NISTP) combines expertise in brain imaging technology with skill and knowledge in clinical applications to addiction for cross-training of postdoctoral trainees. The goal is to foster the development of interdisciplinary scientists who can comfortably apply complex imaging methods to understand the neuroscience of misuse and dependence of cocaine, opiate, nicotine, alcohol, and other substances, as well as treatments for these problems.

PI_NAMEs: MASON, GRAEME F. (contact);SINHA, RAJITA

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: neuroimaging;Science;Training Programs

PROJECT_TITLE: Neuroimaging Sciences Training Program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Training the next generation of scientists in drug abuse research, at this time in history, is one of the pressing needs of NIH. The field needs T32 programs that focus on outcomes that matter to communities. This UF Substance Abuse Training Center in Public Health does just that, thus, serving an importance niche in NIDA’s portfolio.

PI_NAMEs: COTTLER, LINDA B. (contact)

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Public Health;Substance abuse problem;Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (J1)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: This is an application for support for advanced predoctoral and postdoctoral training in quantitative neuroscience. By instructing our trainees in computational modeling and advanced data analysis techniques, we aim to train scientists that will be able to bridge the key gap in our understanding of how the brain works: how do myriad single molecules and neurons collectively give rise to the mind? This is important for both basic science and clinical science - these modeling and data analysis techniques will give trainees a rich vocabulary and a powerful toolkit for exploring how pathologies of small-scale elements (e.g., deficits in neurotransmission at dopaminergic terminals) can lead to mental disorders (e.g., schizophrenia).

PI_NAMEs: DAW, NATHANIEL DOUGLASS;NORMAN, KENNETH A (contact);WITTEN, ILANA

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Grant;National Research Service Awards;Neurosciences;Training

PROJECT_TITLE: NRSA Training Grant in Quantitative Neuroscience


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW HAVEN

PHR: Project Narrative Rapid and inexpensive DNA sequencing technologies have revolutionized medicine by revealing the landscape of mutations that contribute to human disease. Over the next decade, whole genome sequencing of many thousands of individuals, coupled with novel genome editing approaches to determine the impact of specific human mutations in experimental model systems, will provide unprecedented insight into disease mechanisms and empower new strategies for prevention, diagnosis and treatment. This training program will train the next generation of scientists to be able to take full advantage of this sea change in human genetics and prepare them for productive careers in science that will lead to improved human health.

PI_NAMEs: NOONAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Genetic;Genomics;human disease

PROJECT_TITLE: Genetics and Genomics of Human Disease


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SPELMAN COLLEGE

PHR: The U-RISE at Spelman College program will contribute to the College’s strategic plan by elevating and expanding “Spelman’s stellar academic learning environment”. In doing so, U-RISE at Spelman College will prepare Spelman students for acceptance into STEM doctoral programs as they pursue biomedical and behavioral research careers.

PI_NAMEs: BLANKSON, ARABA NAYENA (contact);BRADLEY, DOLORES V.

PROJECT_TERMS: Admission activity;Awareness;Bachelor's Degree;Behavioral;Behavioral Research;Biomedical Research;career;college;Comprehension;Critical Thinking;Data Science;Development Plans;Doctor of Philosophy;Empirical Research;Future;holistic approach;Knowledge;Learning;Participant;programs;Research;Research Design;Research Training;skills;Students;success;summer program;symposium;university student;Update;Work

PROJECT_TITLE: U-RISE at Spelman College

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative The purpose of this training grant renewal, Training Program in Population Studies, is to provide exceptional demographic training to the next generation of social and behavioral scientists. Through mentoring, coursework, and professional socialization, our predoctoral and postdoctoral fellows will learn the necessary skills to identify, analyze, and produce scholarship critical to addressing society’s pressing social and public health issues. Our predoctoral and postdoctoral fellows will benefit from the innovative and high-quality scholarship and expertise of our training faculty and they will learn to conduct research with the highest ethical research standards, scientific rigor, and reproducibility.

PI_NAMEs: CAVANAGH, SHANNON E.;GOOSBY, BRIDGET J (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Population Study;Training Programs

PROJECT_TITLE: Training Program in Population Studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;HIV/AIDS;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Tissue resident macrophages have critical functions in maintaining tissue homeostasis and in the pathogenesis of many human diseases, including Alzheimer’s Disease and multiple sclerosis and in HIV infection. This project will fill a critical need by providing validated humanized platforms for investigating human tissue resident macrophages in vivo during development of disease.

PI_NAMEs: BREHM, MICHAEL ALLEN (contact);GREINER, DALE LESLIE;KUMAR, PRITI ;SCHAFER, DOROTHY PATRICIA;SHULTZ, LEONARD

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Adaptive Immune System;Alzheimer associated neurodegeneration;Alzheimer's Disease;Animal Model;animal model development;APP-PS1;Basic Science;Biology;Birth;Brain;CD34 gene;Cells;Collaborations;Communities;CSF1 gene;cytokine;Data;Development;Disease;Embryo;Engraftment;Evaluation;Generations;Genetic;Genetic Enhancer Element;Goals;Heart;HIV;HIV Infections;Homeostasis;Human;human disease;human tissue;humanized mouse;Immune;Immune response;Immune system;immunodeficiency;Immunodeficient Mouse;Immunology;Impairment;improved;in vivo;Inflammatory;interest;Investigation;Kidney;Knock-out;Liver;Lung;Macrophage;Mediating;medical schools;Microglia;Modeling;Modification;mouse development;mouse model;multidisciplinary;Multiple Sclerosis;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;neuroinflammation;novel;Pathogenesis;Peritoneum;Population;presenilin-1;progenitor;programs;Protein Precursors;radioresistant;Receptor Gene;Regulatory Element;Reporting;Reproducibility;Research;Research Project Grants;Resources;response;Role;Senile Plaques;Study models;Testing;The Jackson Laboratory;Tissue Model;Tissues;Transgenic Organisms;Umbilical Cord Blood;United States National Institutes of Health;Validation;Viral Pathogenesis;Work;Yolk Sac

PROJECT_TITLE: Novel Humanized Mouse Models For Engraftment of Tissue-Specific Human Macrophage Population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PHR: Basic and translational research featuring neotropical primates is growing nationally and globally, but the development of immunological reagents specifically tailored for these animals continues to lag. To optimize the utility of the two most commonly used neotropical primates, we propose to deeply characterize the immunoglobulin repertoire of marmosets, squirrel monkeys, and owl monkeys and engineer species-matched antibodies for lymphocyte depletion. Additional cross-reactive diagnostic antibodies will be identified or generated de novo to support investigators conducting studies in established models of neurodegenerative, infectious, and metabolic diseases.

PI_NAMEs: ENGELMAN, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;African;Aging;Animal Disease Models;Animal Model;Animals;Antibodies;antibody diagnostic;Antibody Response;Antibody Specificity;Aotus primate;Area;Asian;Basic Science;Biological;Biological Assay;Biological Markers;Biomedical Research;Callithrix;Callithrix jacchus jacchus;CD8B1 gene;Cell surface;Cells;Clinical;Communicable Diseases;cross reactivity;Development;Disease;disease model;drug development;Engineering;Funding;Funding Agency;Generations;Goals;IGH@ gene cluster;IGL@ gene cluster;Immune;Immune response;Immune system;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologics;in vivo;infectious disease model;Inflammatory;interest;Lymphocyte Depletion;Lymphocyte Subset;Mediator;Metabolic Diseases;Modeling;Monoclonal Antibodies;MS4A1 gene;Neurodegenerative Disorders;Night Monkey;nonhuman primate;novel;novel therapeutics;novel vaccines;Population;Primates;Production;Reagent;Recovery;Research;Research Contracts;Research Personnel;Resources;Rodent;Saimiri;Surface Antigens;Testing;Time;tool;Transgenic Animals;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Neotropical Primate Reagent Resource


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: This program enhances research training for young scientists to promote the next generation of independent investigators studying childhood blood cancers. Advanced approaches in genomic analysis, experimental modeling, and translational research will be integrated to enhance training for scientists early in their research careers. The long-term goal is to improve the understanding and treatment of childhood blood and lymph cancers by advancing research progress in this field.

PI_NAMEs: MULLIGHAN, CHARLES G. (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: Childhood Hematological Malignancies Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The goal of this proposal is to purchase a Bruker ultra-high preclinical magnet to replace the obsolete 14 Tesla Magnex magnet procured in 2009, which has been dedicated to supporting the high-resolution anatomical and functional mapping of animals and ex-vivo human brain tissue imaging. The upgraded 15.2T preclinical scanner will support over 20 highly synergistic and collaborative research projects, in three main themes: 1) Neurovascular dynamic signaling, 2) Cutting-edge neuroimaging methodology, 3) Multimodal mechanistic signatures of animal disease models.

PI_NAMEs: YU, XIN  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Anatomy;Animal Disease Models;animal imaging;Animal Model;Animals;Biosensor;Blood Vessels;body map;Brain;Brain Diseases;Brain Mapping;Brain Stem;brain tissue;Calcium;cerebrovascular;Coma;Dedications;Dementia;Electronics;ex vivo imaging;Functional Magnetic Resonance Imaging;Funding;General Hospitals;Glutamates;Goals;Human;Image;improved;Injury;instrument;Magnetic Resonance Imaging;Maps;Massachusetts;Mediating;Methodology;Methods;multidisciplinary;multimodal neuroimaging;multimodality;neuroimaging;neurovascular;next generation;novel;optical fiber;optogenetics;Organ;Performance;pre-clinical;Research Personnel;Research Project Grants;Resolution;Resources;Signal Transduction;Software Design;Techniques;Technology;Tissue imaging;translational potential;translational study;Translations;United States National Institutes of Health

PROJECT_TITLE: Upgrade of the Preclinical Horizontal 14T Magnet

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Diabetes is a complex disease, and understanding its complexity is critical for creating new clinical therapies to control the current diabetes epidemic, better treat its complications, and lead to an eventual cure. Because engineering approaches have proven useful for solving complex biomedical problems, we propose to train a new multi-disciplinary work force with the skills needed to integrate both engineering and diabetes research approaches. This will be accomplished through formal course work and an unconventional dual mentor arrangement, where each student or postdoctoral trainee is supervised by one advisor with an engineering background and another from the diabetes research field.

PI_NAMEs: YOUNG, JAMEY D. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Engineering;Training

PROJECT_TITLE: Integrated Training in Engineering and Diabetes

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: HERSHEY

ORG_DEPT: PATHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: We aim to plan and develop rapid imaging instrumentation deployment in DOE, software workflows, data sharing and visualization mechanisms, and educational software towards broad community access to a state- of-the-art, 3-dimensional form of histology, X-ray histotomography, that enables the study of all cell types in whole cm-scale organisms and tissue samples. The proposed work includes pilot studies to image samples at an unprecedented combination of 5 mm field-of-view (FOV) with 0.5 μm isotropic resolution at Lawrence Berkeley National Laboratory and 10 cm FOV/0.7 μm resolution at Argonne National Laboratory, that will be paired with rapid access to web-based instructional material, to facilitate web-based image and file access, and to set the stage for community-based generation of tools for computational tissue phenotyping. The positive impacts of accessible histotomography are expected to advance our understanding of cells and tissues in organismal context, including the study of genetic, environmental, and disease determinants of phenotype, and facilitate the development of shared computational tools across disciplines in biology, toxicology, biosphere monitoring, and disease diagnostics.

PI_NAMEs: CHENG, KEITH CHI (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: 3-Dimensional;3D virtual reality;Acceleration;Acetaminophen;Address;Algorithms;Anatomy;Awareness;base;beamline;Biology;Biomedical Research;Cell model;Cell Physiology;cell type;Cells;Chicago;climate change;Clinical;Clinical Medicine;cloud based;Collaborations;Communities;Computer software;computerized tools;computing resources;Consultations;Daphnia;Data;data access;data acquisition;Data Set;data sharing;data tools;data visualization;denoising;design;Development;Diagnostic;digital;Discipline;Disease;disease diagnostic;disease phenotype;E-learning;Education;Environment;Environmental Monitoring;Excision;file format;Foundations;gene environment interaction;Generations;Genes;Genetic;Genetic study;Geometry;Goals;Health;High Performance Computing;Histologic;Histology;Histopathology;Human;Human Biology;human disease;human model;Human Resources;Image;image reconstruction;imaging facilities;improved;instrumentation;Invertebrates;Investigation;Isotropy;Laboratories;large scale data;large-scale imaging data;Leadership;learning materials;Life;Metals;Methods;Microanatomy;microCT;Modality;model organism;Modeling;Molecular;Monitor;Morphologic artifacts;multidisciplinary;mutant;next generation;Normalcy;Observational Study;Online Systems;Organ;Organism;Outcome;Persons;Phase;phenomics;Phenotype;Pilot Projects;pleiotropism;Process;processing speed;reconstruction;Reproducibility;Research;Resolution;Resources;Retrieval;Roentgen Rays;Sampling;Scanning;scientific computing;Secure;Shapes;soft tissue;Specimen;Speed;Stains;submicron;symposium;Synchrotrons;System;Texture;Three-Dimensional Image;Three-Dimensional Imaging;Time;Tissue Sample;Tissues;tomography;tool;tool development;Toxic effect;Toxicology;Training;two-dimensional;ultra high resolution;Universities;Validation;Visualization;Whole Organism;Width;Work;X-Ray Tomography;Zebrafish

PROJECT_TITLE: Building a Wide-field, High-resolution Histotomography Resource for Biology


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

PHR: NARRATIVE Atherosclerotic cardiovascular disease (CVD) remains the leading cause of death worldwide and substantial residual CVD risk persists despite effective LDL-cholesterol (LDL-C) lowering. In this context, we propose an investigation of mechanisms of plaque stabilization and destabilization focused on novel functions of vascular macrophages and stromal cells, and their crosstalk, in mouse models and human CVD. Our overarching theme, pursued through three highly integrated Projects and two Scientific Cores is that inflammation and the efferocytosis-resolution cycle in macrophages regulates plaque stability through crosstalk with other macrophages and stromal cells and that detailed examination of the cell and molecular mechanisms may provide opportunities for novel CVD treatments, including in patients with clonal hematopoiesis, an emerging CVD risk factor.

PI_NAMEs: TALL, ALAN RICHARD (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Address;Adopted;Affect;Anti-Inflammatory Agents;Antibodies;Area;Arterial Fatty Streak;Atherosclerosis;biobank;Bioinformatics;Biological;Biological Assay;Biometry;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Artery Plaques;Cause of Death;Cell Lineage;cell type;Cells;Clinical;clinically relevant;Collaborations;CRISPR screen;Data;Development;disease model;DNMT3a;expectation;Fibroblasts;gene therapy;Genes;genome-wide;Growth;Hematopoiesis;Human;Impairment;improved;In Situ;in vivo;Inflammasome;Inflammation;Inflammatory;innovation;Interleukin-1 beta;Investigation;LDL Cholesterol Lipoproteins;Lesion;Link;Macrophage;Maps;Mesenchymal Stem Cells;Methods;Modeling;Molecular;mouse model;Mus;Mutation;nanoparticle;Necrosis;novel;novel strategies;novel therapeutics;Paper;Pathway interactions;Patients;Phenotype;Polyploidy;Population;Process;programs;Public Health;Publishing;Research;Residual state;Resolution;Resources;Risk Factors;Role;Sampling;Shapes;single-cell RNA sequencing;Small Interfering RNA;Smooth Muscle Myocytes;Specimen;Stains;stem cell fate;Stromal Cells;targeted treatment;Therapeutic;Therapeutic Intervention;therapy design;Thick;Thinness;Tissues;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;TREM2 gene;Variant;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms of Atherosclerosis

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP (JA)]


PROJECT_TERMS: Accounting;Advisory Committees;Agreement;animal research subject;Atherosclerosis;Blood Vessels;Budgets;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Communication;Data;data exchange;data sharing;Documentation;Ensure;Ethics;Expenditure;experimental study;Fostering;Grant;Hematopoiesis;high standard;Hospitals;Human;Human Resources;human subject;Human Subject Research;Hybrids;IACUC;Individual;Inflammation;Institutional Review Boards;Joints;Lead;Legal;Macrophage;material transfer agreement;meetings;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;National Heart, Lung, and Blood Institute;novel;Occupational activity of managing finances;Organizational Productivity;Patients;Periodicals;Persons;Principal Investigator;Productivity;programs;Protocols documentation;Publications;Reagent;Reporting;Research;Research Personnel;Resolution;Resource Sharing;Resources;Review Committee;Risk Factors;Schedule;Services;Shipping;Stromal Cells;success;Technology;Travel;United States;Universities;Vertebrates;virtual;Woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

PI_NAMEs: REILLY, MUREDACH P (contact)

PROJECT_TERMS: Address;analysis pipeline;Arterial Fatty Streak;Atherosclerosis;Bioinformatics;Biometry;Biostatistics Core;Cardiovascular Diseases;cardiovascular risk factor;Cause of Death;Cell Communication;Cell Cycle;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Data;cost;Data;Data Analyses;data sharing networks;denoising;differential expression;Ensure;Ethics;Event;Experimental Designs;Genes;Goals;high standard;Histology;Human;Image;Immunofluorescence Immunologic;Inflammasome;Institution;Intervention;Lead;Lipids;Macrophage;Molecular;mouse model;Mus;Myocardial Infarction;Pathway Analysis;Pathway interactions;Phenotype;Process;programs;Quality Control;Reproducibility;Research;Research Design;Residual state;Resources;Risk;RNA;Sampling;Sequence Alignment;Services;single cell analysis;single-cell RNA sequencing;skills;Tissues;transcriptome sequencing;transcriptomics;Translations;Variant

PROJECT_TITLE: Bioinformatics and Biostatistics


PI_NAMEs: WANG, NAN  (contact)

PROJECT_TERMS: Address;Apoptosis;Area;Arterial Fatty Streak;Atherosclerosis;biobank;Biological Assay;Biometry;Blinded;Blood Vessels;Cell Count;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Classification;Communication;Data;Development;Ensure;Experimental Designs;Fee-for-Service Plans;Fibroblasts;Funding;Genetic Transcription;Human;Human Resources;In Situ;Individual;Inflammation;Instruction;interest;Learning;Lesion;Macrophage;Maps;Measurement;Medical History;Molecular;Mus;Necrosis;novel;Patients;Preparation;programs;Proliferating;Protocols documentation;Reproducibility;Research;Research Personnel;Resolution;Rupture;Sampling;Services;Shapes;single-cell RNA sequencing;Smooth Muscle Myocytes;Stains;Standardization;standardize measure;Stromal Cells;Techniques;Technology;Thick;Tissue Sample;Tissues;Training;transcriptome sequencing;transcriptomics;Universities;Variant;Work

PROJECT_TITLE: Mouse and Human Atherosclerotic Tissue


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Acceleration;Age;Aging;Alleles;antagonist;Antibodies;Arterial Fatty Streak;Atherosclerosis;biobank;Blood Cells;Blood Vessels;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Carotid Artery Plaques;Cells;Clinical;Collaborations;Cytokine Signaling;DNMT3a;Epigenetic Process;experimental study;Fibroblasts;fitness;Frequencies;Genes;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Immune;Immunosuppression;improved;Infection;Inflammasome;Inflammatory;Interleukin-1;Interleukin-1 beta;JAK2 gene;Lesion;Link;Macrophage;Maps;Mediating;Mesenchymal Stem Cells;Modification;Molecular;mouse model;Mus;mutant;Mutation;Myeloid Cells;Myocardial Infarction;Necrosis;novel;Outcome;Pathway interactions;Patients;Population;premature;Production;Resolution;Risk Factors;Role;single-cell RNA sequencing;Somatic Mutation;Stromal Cells;synergism;targeted treatment;Techniques;Testing;Therapeutic;Thick;Thinness;Transforming Growth Factor beta;Transgenic Organisms;translational study;Transplantation;TREM2 gene;Variant;Visualization

PROJECT_TITLE: Inflammatory crosstalk between macrophages and stromal cells in clonal hematopoiesis


PI_NAMEs: TABAS, IRA A (contact)

PROJECT_TERMS: Affect;Apoptotic;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Blood Vessels;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Collaborations;Collagen;Dangerousness;Data;demethylation;DNA Modification Methylases;Feedback;Genetic Markers;Hematopoiesis;Histology;Human;Impairment;In Vitro;Inflammation;insight;Knockout Mice;Lactic acid;Lesion;Link;loss of function;Low-Density Lipoproteins;Macrophage;Mediating;Messenger RNA;Metabolic;Metabolic Pathway;Methionine;Methylation;Modeling;Molecular;Mus;MYC Family Protein;nanoparticle;nanotherapy;novel therapeutics;Nucleotides;Pathway interactions;Plasma;prevent;Process;Production;Proliferating;promoter;Publishing;Repression;Resolution;Risk;Risk Factors;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stromal Cells;Testing;Thinness;Tracer;Variant

PROJECT_TITLE: Macrophage Metabolic Pathways and Cellular Crosstalk in Atherosclerosis Regression


PI_NAMEs: ZHANG, HANRUI  (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Acute;Address;Affect;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;biobank;Blood Vessels;Bone Marrow;cardiovascular disorder risk;Cardiovascular system;Cells;Clinical;CRISPR screen;Cytokinesis;Data;Data Set;DNMT3a;Event;Excision;Genes;genome-wide;Guide RNA;Hematopoiesis;Histologic;Human;Impairment;In Situ;In Vitro;in vivo;Inflammation;insight;JAK2 gene;knock-down;Knock-out;Knowledge;lentiviral-mediated;Lesion;lipid nanoparticle;Lipids;Macrophage;Maps;Mediating;Membrane;Messenger RNA;Molecular;monocyte;Mononuclear;Mus;Mutation;MYC Family Protein;Myelogenous;nanoparticle delivery;Necrosis;novel;novel strategies;novel therapeutics;Patients;Phagocytes;Phenotype;Polyploidy;Process;Proliferating;protein function;Proteins;Residual state;Resolution;Risk;Risk Reduction;Role;single-cell RNA sequencing;Small Interfering RNA;Stromal Cells;Testing;Therapeutic;Thick;transcriptomics;Transplantation;western diet;Work

PROJECT_TITLE: Harnessing molecular breaks on macrophage efferocytosis in atherosclerosis


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Hematology;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative: Despite medical advances for the treatment of osteopetrosis, all available therapies require conditioning treatment for cell engraftment. Here we propose to combine CRISPR/Cas9 genome editing for correction of osteopetrosis-causing mutations in the Clcn7 gene with autologous infusions that do not require conditioning to restore bone resorption in experimental osteopetrosis, with potential implications for the clinic.

PI_NAMEs: JACOME-GALARZA, CHRISTIAN E (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;Albers-Schonberg disease;Allogeneic Bone Marrow Transplantation;Alternative Therapies;antiporter;Autologous;autosome;base editing;base editor;Biology;bone;bone cell;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;bone mass;Bone Regeneration;Bone remodeling;Bone Resorption;Cell Therapy;cell type;Cells;Central Nervous System;Cessation of life;chemotherapy;Chimerism;Chloride Channels;Clinic;Clinical;clinical care;Clinical Trials;conditioning;CRISPR correction;CRISPR/Cas technology;Defect;density;Dependovirus;design;Development;Eligibility Determination;Engraftment;Etiology;Fracture;gene therapy;Genes;Genetic;Genetic Diseases;genetically modified cells;Genome;genome editing;Goals;graft vs host disease;Grant;Hearing;Hematologic Neoplasms;Hematological Disease;Hematopoietic stem cells;Heritability;human disease;Human Genetics;Impairment;improved;In Vitro;in vivo;Incidence;individual patient;Infection;Infusion procedures;Injections;Innate Bone Remodeling;irradiation;Knock-out;life span;loss of function mutation;Mediating;Medical;monocyte;mortality;Mouse Embryonic Stem Cells;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;mutation correction;neonate;Nerve Degeneration;Neurodegenerative Disorders;novel;novel strategies;novel therapeutics;osteoclast progenitor;Osteoclasts;Osteomyelitis;Pathology;Patients;Phenotype;physically handicapped;Positioning Attribute;Procedures;Proteins;Protocols documentation;Publishing;Quality of life;Refractory;Reporting;Sickle Cell Anemia;skeletal disorder;Spinal Muscular Atrophy;Syndrome;Technology;Testing;Therapeutic;Tissues;tool;Tooth eruption;Toxic effect;Transplantation;transplantation therapy;treatment strategy;Validation;vector induced;Visual impairment;Waiting Lists;Work

PROJECT_TITLE: Genetic editing and cell therapy for correction of CLCN7 mutations in osteopetrosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The Quantitative Biological Systems Training (QBIST) program aims to equip biology PhD trainees from diverse backgrounds with robust quantitative and computational skills and to provide training in mentoring, leadership, and professional skills, thereby preparing scientists for a variety of careers in the biomedical research enterprise. The QBIST program will study the impact on training and research outcomes of an integrated quantitative curriculum and activities that incorporate formal instruction and facilitated experience in leadership and mentoring. In addition, by implementing a non-academic internship and entrepreneurial program, the QBIST program will expose trainees to careers outside the traditional academic track, and assess the impact of these activities on trainee career preparedness and perceptions of training utility.

PI_NAMEs: GRESHAM, DAVID  (contact);VOGEL, CHRISTINE

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: biological systems;Training Programs

PROJECT_TITLE: The Quantitative Biological Systems Training (QBIST) Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Principal Investigator: Robertson, Erle S. Narrative: The Tumor Virology Training Program at the University of Pennsylvania serves as the central forum for facilitating interactions among investigators involved in cancer-related viral research on the Penn campus which provides a more directed training for trainees.

PI_NAMEs: ROBERTSON, ERLE S. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Training;tumor;virology

PROJECT_TITLE: Training in Tumor Virology


ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Our goal is to build a rigorous training program that enables PhD graduate students and postdoctoral fellows to become translational researchers who seek to understand muscle biology and decipher the mechanisms of its dysfunction in order to develop innovative strategies for effective diagnosis and treatment of muscular dystrophies (MDs). We emphasize highly collaborative multidisciplinary team science with exposure to both rigorous basic and clinical MD research.

PI_NAMEs: MOZAFFAR, TAHSEEN ;VILLALTA, SERGIO ARMANDO;YOKOMORI, KYOKO  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Muscle;Research;Training

PROJECT_TITLE: MAXIMUS: MAXimizing Training in MUScle Research


NIH_SPENDING_CATS: Aging

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative This T32 training grant continues to successfully train the scientists of tomorrow in aging research at Einstein. This success is based on the quality of candidates, their scientific and academic achievements, the percent of trainees who have stayed in research, and the number of minority individuals trained. Within our highly collaborative environment lies a strong emphasis on translational research from a diverse group of mentors who are well-funded and who have access to a diverse pool of well-qualified trainees. We continue the Biology of Aging class developed specifically for this grant and our highly successful hackathon to teach rigor and reproducibility, while also adding new and diverse mentors and activities to enrich the training experience.

PI_NAMEs: BARZILAI, NIR J (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Aging;Research;Training

PROJECT_TITLE: Training in Aging Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH Precision medicine holds promise for enhancing best care options at the patient level, thereby closing disparity gaps (caused by inefficient or non-tailored, “one size fits all” therapies) leading to immediate and meaningful impact on population health. The Kansas Institute for Precision Medicine through Phase 2 COBRE funding will provide promising junior investigators with a focused mentoring experience that will help them mature into independently-funded investigators who will contribute to the advancement and clinical realization of precision medicine.

PI_NAMEs: GODWIN, ANDREW K. (contact);SOPER, STEVEN ALLAN;YU, ALAN S

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Advisory Committees;Area;Autoimmune Diseases;Awareness;Basic Science;biobank;Biological Markers;biomarker development;biomarker validation;Biomedical Engineering;Brain;Businesses;cancer type;career;Caring;Centers of Research Excellence;Characteristics;Chronic Childhood Arthritis;Clinical;clinical practice;Clinical Trials;Committee Members;Communication;Communities;community engagement;companion diagnostics;complex data;Cystic Fibrosis;Data Set;Development;Diagnosis;diagnostic technologies;Discipline;Disease;disparity gap;Education;experience;Faculty;FDA approved;Fostering;Funding;Generations;Genetic;genetic variant;Goals;Grant;Growth;Healthcare;Human;implementation science;improved;Individual;Infrastructure;innovation;innovative technologies;Institution;Interstitial Lung Diseases;Kansas;Leadership;Life Style;liquid biopsy;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Medical;Medical center;Medicine;meetings;member;Mentors;Mentorship;Methods;Microbe;Mission;Modeling;Molecular;Molecular Profiling;multiple omics;next generation;Oncology;organizational structure;outreach program;Pathogenicity;Patient Care;patient engagement;Patient-Focused Outcomes;Patients;Peer Review;personalized approach;personalized diagnostics;Phase;Physicians;Pilot Projects;population health;Positioning Attribute;precision medicine;predictive marker;prevent;Process;Prognostic Marker;Program Sustainability;programs;Public Health;radiomics;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Resources;Risk Factors;Schizophrenia;Scientific Inquiry;Scientist;Seasons;Secure;Services;Shapes;Structure;success;targeted treatment;Technology;Testing;Therapeutic;Time;tool;Training;Translational Research;translational research program;tumor progression;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Precision Medicine

PI_NAMEs: GODWIN, ANDREW K. (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Area;Award;biobank;biomarker validation;Biomedical Engineering;Biomedical Research;biomedical scientist;career development;Centers of Research Excellence;Communities;community engagement;Dedications;design;Development Plans;Disease;Doctor of Philosophy;Education;Environment;Faculty;Financial Support;Fostering;Funding;Goals;Grant;Growth;Healthcare;information organization;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;interest;Kansas;Leadership;Medical center;meetings;member;Mentors;Mission;Monitor;National Institute of General Medical Sciences;novel;Office of Administrative Management;Organization and Administration;outreach program;Parents;patient engagement;Patients;Performance;Phase;Pilot Projects;Play;Positioning Attribute;Precision Health;precision medicine;Precision Medicine Initiative;Principal Investigator;Program Research Project Grants;programs;Progress Reports;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Scientist;Seasons;success;tool;Training;Translational Research;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Nanotechnology;Precision Medicine

PI_NAMEs: SOPER, STEVEN ALLAN (contact)

PROJECT_TERMS: Automobile Driving;base;Biological;Biological Assay;Biological Markers;Biology;Biomedical Engineering;Biomedical Technology;Biotechnology;Blood;Businesses;cell free DNA;Cell Separation;Cells;Centers of Research Excellence;Clinic;Clinical;Clinical Research;Collaborations;Communities;Computer software;cost;Data;design;Devices;Disease;Engineering;Equipment;exosome;extracellular vesicles;fabrication;Faculty;Fees;Funding;Grant;Human Resources;improved;individualized medicine;Infrastructure;Injections;innovation;innovative technologies;Institution;instrumentation;International;Kansas;Leadership;liquid biopsy;Liquid substance;Measurement;Medical;meetings;Microfluidic Microchips;Microfluidics;MicroRNAs;millimeter;minimally invasive;Minority;Mission;Modeling;Molds;Molecular;Molecular Analysis;molecular marker;nanometer;nanopattern;Nanostructures;Nature;Neoplasm Circulating Cells;new technology;novel therapeutics;Occupations;operation;Output;Patient Care;Patient-Focused Outcomes;Patients;Pattern;personalized care;Phase;Plasma;Plastics;Population;precision medicine;Private Sector;Procedures;Production;Proteins;Publications;Records;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Robot;Saliva;Sampling;Seasons;Secure;Services;single molecule;social media;Source;square foot;Structure;Surveys;Technology;technology platform;tool;Translating;Translational Research;United States National Institutes of Health;Urine;web site

PROJECT_TITLE: Biomedical Engineering Core