ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our ability to diagnose and treat neurodevelopmental disorders and brain tumors is critically dependent on fundamental understanding of cellular and molecular mechanisms that regulate neural stem cell self-renewal and differentiation in vivo. Research described in this proposal will uncover new and potentially evolutionarily conserved mechanisms governing these processes. If successful, it will have a broad impact on the understanding of human brain development and associated brain disorders.

PI_NAMEs: GUO, SU  (contact)

PROJECT_TERMS: Address;Adult;Anaphase;Anterior;Apical;Biochemical;Biophysics;Brain;Brain Diseases;Brain Neoplasms;Cell Cycle;Cell division;Cell Fate Control;Cell model;Cell Polarity;cell type;Cells;Complex;Coupled;Cytoplasm;Cytosol;Data;Daughter;daughter cell;density;Development;Diagnosis;Disease;Dynein ATPase;Embryo;Endosomes;Ensure;Equilibrium;Etiology;Exhibits;genetic approach;Homeostasis;Human;Image;imaging genetics;In Vitro;in vivo;in vivo imaging;insight;Intellectual functioning disability;Interphase;Invertebrates;Ligands;Light;Link;Microtubules;Mitosis;Mitotic;Molecular;Molecular Genetics;Morphogenesis;Mothers;Motility;Motor;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neuroglia;notch protein;novel therapeutics;Phosphorylation;Photobleaching;planar cell polarity;Play;Positioning Attribute;Process;progenitor;Property;Prosencephalon;protein complex;Proteins;Public Health;Radial;reconstruction;Recovery;repaired;Research;Role;segregation;self-renewal;Shapes;Signal Transduction;Specific qualifier value;stem cell self renewal;superresolution microscopy;System;telophase;Testing;therapeutic development;Time;Tissues;tumorigenesis;Work;Zebrafish

PROJECT_TITLE: Asymmetric Cell Division of Vertebrate Radial Glia Neural Progenitors

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Type 2 Diabetes is a common, complex health condition which can result in many serious and costly health complications if not treated and controlled properly. Overall, 24% of Veterans are diagnosed with Type 2 Diabetes. Vulnerable Veterans, such as minority, low-income, or rural Veterans, and Veterans with comorbid mental health diagnoses, are disproportionately affected and are less likely to have their diabetes under control. One way to help Veterans improve their diabetes control is through the use of technology to help provide information, motivation, and reminders necessary to support diabetes self-management. This study seeks to leverage “Annie”, a new VA texting system. The study will seek input from vulnerable Veteran groups living with diabetes to help develop DD-TXT, a new customizable, interactive texting intervention that allows Veterans to choose what kinds of diabetes self-management support they need, and when. It will compare DD- TXT with another education-only texting intervention called DSE that is based on a diabetes skills workbook.

PI_NAMEs: SHIMADA, STEPHANIE LEAH (contact)

PROJECT_TERMS: Address;Adherence;Affect;African American;Appointment;Area;Behavior;Blood Glucose;blood pressure control;Blood Pressure Monitors;Cellular Phone;Chicago;Chronic Disease;comorbidity;comparative effectiveness;comparative effectiveness trial;Complex;complex chronic conditions;connected care;coping;cost;Data;design;Development;diabetes control;diabetes distress;Diabetes Mellitus;diabetes self-management;diabetic;Diagnosis;digital divide;Disease;Disparity;Education;Effectiveness;effectiveness evaluation;Emotional;empowerment;Evaluation;experience;Feedback;field study;Future;future implementation;General Population;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care availability;Health Care Costs;health equity;Health Expenditures;Health Services Accessibility;Healthcare;Heart;Heterogeneity;Hybrids;implementation strategy;implementation trial;Improve Access;improved;individual patient;Informatics;information gathering;innovation;Intervention;Lead;Libraries;literacy;Logic;Low income;Low-Density Lipoproteins;medical complication;medication compliance;Medication Management;Medicine;member;Mental Health;Methodology;Minority;Modality;Monitor;Morbidity - disease rate;mortality;Motivation;multidisciplinary;Names;Non-Insulin-Dependent Diabetes Mellitus;Nurses;nutrition;Outcome;Ownership;Participant;patient engagement;Patient Preferences;Patient Selection;Patient Self-Report;Patient-Centered Care;Patients;Pharmaceutical Preparations;Physical activity;Physiological;population health;preference;Preventive care;primary care practice;primary outcome;Problem Solving;Process;protocol development;Protocols documentation;Provider;Randomized;Recommendation;Research Priority;Resources;Risk Factors;Rural;Safety;secondary outcome;Self Efficacy;Self Management;self-management program;skills;social health determinants;sociodemographics;Subgroup;success;System;Technology;technology platform;Testing;Text;Text Messaging;text messaging intervention;texting support;Time;treatment as usual;treatment effect;Veterans;virtual;virtual healthcare;Weight maintenance regimen;Woman;Women's Health;Work

PROJECT_TITLE: Diabetes Disparities: Texting to Extend Treatment (DD-TXT)

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Suicide;Violence Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PI_NAMEs: CANCILLIERE, MARY KATHRYN MELONIO (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Adherence;Admission activity;aged;Centers of Research Excellence;Communities;Development;effectiveness/implementation trial;Enhancement Technology;evidence base;Family;Health system;Hospitals;Injury;interest;Intervention;intervention refinement;Literature;Manuals;Measures;Mental Health;Mental Health Services;Modeling;National Institute of Mental Health;navigator intervention;Outcome Study;pandemic disease;pediatric emergency;Pilot Projects;Prevalence;Prevention Protocols;primary outcome;Protocols documentation;Qualitative Methods;Randomized;Rhode Island;Risk;Risk Reduction;Self-Injurious Behavior;Site;Speed;suicidal;suicidal risk;Technology;Text;text messaging intervention;Therapeutic;Translational Research;treatment as usual;Youth

PROJECT_TITLE: The development of a family navigator intervention and prevention protocol to reduce risk of suicide and self-injurious behavior for youth aged 10 to 14 years.


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative This proposal uses in vitro, in cellulo and in vivo strategies to understand the mechanism of action of a new class of small molecules, modified polycyclic compounds (MPCs), to address the unmet need for therapeutics for Myotonic Dystrophy (DM), the most common cause of muscular dystrophy. A design-model-test cycle will be used to understand the mechanism(s) of action of these new compounds, systematically refine their efficacy and test their therapeutic potential in patient-derived DM cells lines and animal models. The successful completion of this project will provide a new class of small molecules, a better understanding of their mechanism of action and in vivo data from multiple animal models supporting their future therapeutic potential – all critical steps towards future clinical studies for this complex and devastating disease.

PI_NAMEs: BERGLUND, ANDREW  (contact);NAKAMORI, MASAYUKI ;REDDY, KAALAK

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: ABCB1 gene;Address;Affinity;Alleles;Animal Model;benzimidazole;Binding;Biological Assay;Biological Availability;Biology;Brain;Calorimetry;candidate identification;candidate selection;Cell Line;Cell model;Cell Survival;Clinical Research;Complex;CUG repeat;Dactinomycin;Data;design;Diamidine;Disease;DNA;DNA Maintenance;drug candidate;efficacy study;Elements;Event;Exons;Family;Future;gain of function;Genetic Transcription;Goals;Hand Strength;Hela Cells;Histopathology;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Lead;lead candidate;Longitudinal Studies;Measures;Mediating;melting;Microtubules;model design;Modeling;Modification;Molecular;molecular modeling;monolayer;mouse model;Muscle;Muscular Dystrophies;Myotonia;Myotonic Dystrophy;nanomolar;Nerve Degeneration;neuromuscular;novel therapeutics;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;Poison;Polycyclic Compounds;preclinical study;Property;Proteins;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Series;Side;small molecule;small molecule therapeutics;Solubility;System;Testing;Therapeutic;Toxic effect;Transcript;transcriptome sequencing;transcriptomics;uptake;water solubility;Weight

PROJECT_TITLE: Design, Synthesis and Efficacy of New Small Molecule Therapeutics to Impede Myotonic Dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Childhood Leukemia;Genetics;Hematology;Nanotechnology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PI_NAMEs: BOBBALA, SHARAN KUMAR REDDY (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acute;antileukemic activity;aqueous;B Cell Proliferation;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;bcr-abl Fusion Proteins;Cells;Charge;Chromosomes;combinatorial;Data;Development;Diagnosis;Encapsulated;Genes;Hand;high risk;hydrophilicity;In Vitro;in vivo;innovation;Kinetics;knock-down;Ligands;Lip structure;lipid nanoparticle;Mitochondrial Proteins;Modeling;nanoparticle;Nucleic Acids;Philadelphia;Relapse;Signal Transduction;Small Interfering RNA;small molecule;small molecule therapeutics;Solvents;STAT protein;Stat5 protein;Subgroup;System;Technology;Testing;Therapeutic;treatment strategy;Tumor Burden;tumor microenvironment

PROJECT_TITLE: Combinatorial targeting for the treatment of B-cell acute lymphoblastic leukemia


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Bacteria are protected from the surrounding environment by a multi-layer structure known as the cell envelope. In this study, I will characterize how a recently identified, conserved, and essential protein maintains cell envelope integrity in the animal pathogen Brucella ovis. This work will provide new understanding of how the Alphaproteobacteria, which includes the genus Brucella, sustain cellular integrity in the face of inhospitable environmental conditions.

PI_NAMEs: ALAKAVUKLAR, MELENE  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Affect;Alphaproteobacteria;Animals;Architecture;Attenuated;attenuation;Bacteria;Bacterial Infections;base;Binding;Biochemical;Biogenesis;Biological Assay;Brucella;Brucella abortus;Brucella ovis;Caulobacter;Cell division;cell envelope;Cell membrane;Cell Physiology;Cell Wall;Cells;Cellular Structures;comparative;Cryoelectron Microscopy;Data;Defect;Enteral;Enterobacteriaceae;env Gene Products;Environment;environmental stressor;Enzymes;Escherichia coli;Essential Genes;Experimental Models;experimental study;genomic locus;Glycoconjugates;Goals;Gram-Negative Bacteria;Growth;human pathogen;In Vitro;in vivo;Infection;insight;Investigation;Knowledge;Lipid A;Lipids;Lipopolysaccharides;Maintenance;Mammals;Membrane;Modeling;Modification;Molecular;mouse model;Mutation;Names;novel;Nucleotides;pathogen;Peptidoglycan;periplasm;Periplasmic Proteins;Phosphatidylinositols;Phospholipids;Plants;Polysaccharides;Protein Family;Proteins;Publishing;Research;Resistance;Role;Stress;stressor;Structure;Suppressor Mutations;System;Testing;Virulence;Work

PROJECT_TITLE: Functional analysis of a novel cell envelope integrity protein in Brucella ovis


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: No technology to date can provide customized therapy that adapts to the individual’s needs with regard to the specific FoG triggering scenarios. The wearable sensor and smart-phone system proposed has the potential to detect different environmental triggers and deliver an optimized dose of vibration at the precise moment it is needed. For people who are isolated in their homes and at risk for falls due to FoG, this new technology has potential to improve their mobility, independence and quality of life; and have important economic benefits for patients, their families, and for the health-care system as a whole.

PI_NAMEs: CLOUD, LESLIE J;PRETZER-ABOFF, INGRID A (contact);ZHOU, GANG

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Awareness;Cellular Phone;Clinical;Controlled Environment;design;Detection;Devices;Dose;Economics;Elevator;Environmental Risk Factor;fall risk;Family;foot;Freezing;Frequencies;Gait;Goals;Healthcare Systems;Home;improved;Individual;individualized medicine;Intention;Medical;Mission;motion sensor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;new technology;Operative Surgical Procedures;Parkinson Disease;Patients;Persons;Positioning Attribute;prevent;programs;psychologic;Psychological Factors;Quality of life;response;Stimulus;System;tactile stimulation;Technology;Testing;Therapeutic;Time;Universities;vibration;Virginia;Visual;Walking;wearable device;wearable sensor technology;Work

PROJECT_TITLE: SCH: Context-aware Freezing of Gait mitigation in real-world setting


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Fentanyl and other ultrapotent opioids interfere with the normal functioning of brainstem circuitry that controls breathing leading to potentially fatal respiratory depression. The proposed studies will provide mechanistic details on serotonergic mechanisms involved in respiratory depression to inform how the serotonin system could be leveraged to combat acute fentanyl toxicity. The outcomes of this research will advance our understanding of the pontomedullary circuitry that controls breathing and provide timely assessment of the safety of co-use of drugs activating 5HT2A receptors, such as serotonergic psychedelics, with fentanyl.

PI_NAMEs: LEVITT, ERICA SAWYER (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Acute;Agonist;Animals;antagonist;Area;awake;Brain;Brain Stem;Breathing;combat;Data;Development;Disadvantaged;Dose;Drug usage;Electrophysiology (science);experimental study;Fentanyl;Future;Goals;Hallucinogens;improved;in vivo;insight;interest;Label;Location;Measures;Mediating;Microinjections;mu opioid receptors;Mus;Naloxone;naloxone dosing;Neuromodulator;Neurons;neuropsychiatric disorder;Opioid;Opioid Antagonist;opioid overdose;Opioid Receptor;Opioid Receptor Binding;opioid use disorder;optogenetics;Outcomes Research;Perfusion;pharmacologic;Pontine structure;positive allosteric modulator;postsynaptic;preclinical efficacy;Preparation;presynaptic;receptor;Receptor Activation;Reporting;respiratory;Respiratory Failure;Respiratory Stimulants;Role;safety assessment;Serotonergic System;Serotonin;Serotonin Agents;Serotonin Agonists;serotonin receptor;side effect;Site;Slice;Synapses;synthetic opioid;Testing;Therapeutic;Toxic effect;Ventilatory Depression

PROJECT_TITLE: Serotonin mechanisms in fentanyl-induced respiratory depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-N (M1)]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Physical function in older age is among the best predictors of independence and disability and social determinants of health (SDOH) play a critical role in shaping physical function, yet the biologic mechanisms linking SDOH to physical performance are poorly understood. The goal of this proposal is to establish the reliability and validity of using the respirometry in frozen samples (RIFS) method on HRS frozen blood samples to obtain measures of mitochondrial function, and then to examine whether these mitochondrial measures relate to socioeconomic position and physical function. The results of this study will provide important evidence that measures of mitochondrial function, obtained via the RIFS method, can be related to social factors and other important aging-related outcomes and has broad potential to, for the first time, open access to large- scale population-based aging studies with existing biorepositories.

PI_NAMEs: DUCHOWNY, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Adenosine Triphosphate;Adult;Age;age related;Aging;aging population;aging related;allostatic load;Area;biobank;Bioenergetics;Biological;Biological Process;Blood;Blood Cells;Blood specimen;blood-based biomarker;Chronic;Chronology;cost effective;Data;disability;Early Diagnosis;Early Intervention;Education;Elderly;Equilibrium;experience;field study;Freezing;Gait speed;Goals;Hand Strength;Health;Health and Retirement Study;high reward;human old age (65+);Impairment;Individual;Inflammation;innovation;Investigation;Life Cycle Stages;Link;low socioeconomic status;Measures;Methodology;Methods;minimally invasive;Mitochondria;novel;Occupations;Outcome;Peripheral Blood Mononuclear Cell;Physical Function;Physical Performance;Physical shape;Play;population based;population health;Population Study;Positioning Attribute;predictive marker;reconstitution;Respiration;Role;Sampling;Skeletal Muscle;social;social factors;social health determinants;social structure;Socioeconomic Status;socioeconomics;Spirometry;Techniques;Testing;Time;Tissues;Validity and Reliability

PROJECT_TITLE: Examining the relationship between blood-based mitochondrial bioenergetic capacity in frozen samples, socioeconomic position, and physical functioning

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: RICHARDSON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project narrative To gain a deeper understanding of long-range airborne pathogen transmission, it is essential to investigate how pathogens behave within different sizes of bioaerosols under various environmental conditions. To achieve this, we propose a novel and easily constructed bioaerosol generator, which can produce monodisperse bioaerosols, making it possible to study the size-dependence of viable pathogen transmission. We will design and build the bioaerosol generator, and investigate the size dependent viability decay for Respiratory Syncytial Virus (RSV) under various environmental conditions.

PI_NAMEs: OUYANG, HUI  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 2 year old;2019-nCoV;Address;aerosolized;Aerosols;Affect;Air;Animals;Area;Atomizer;Bacteria;Biological Assay;Breathing;cost;Cost of Illness;Coughing;Coupled;COVID-19 pandemic;Data;Dependence;Deposition;design;digital;disorder control;Engineering;Equilibrium;fungus;Future;Generations;Human;Humidity;Infant;Infection;influenzavirus;insight;instrument;interest;Investigation;Lead;Location;Lower Respiratory Tract Infection;Lung;manufacture;Measurement;Measures;Methods;Modeling;nonhuman primate;Normal Statistical Distribution;novel;Nucleic Acids;Organism;Outcome;particle;Particle Size;pathogen;Play;Porcine Reproductive and Respiratory Syndrome;Reaction;Reporting;Research;respiratory;Respiratory syncytial virus;Respiratory System;Respiratory Tract Infections;Rodent;Role;Scanning;Seasons;Severities;Sneezing;Solid;success;Suspensions;System;Techniques;Temperature;Testing;Time;tool;transmission process;Travel;Ultraviolet Rays;Upper respiratory tract;UV Radiation Exposure;ventilation;Viral Load result;viral transmission;Virion;virtual;Virus;Water;Work

PROJECT_TITLE: Probing the particle size-viability relationship in bioaerosols through size-controlled measurements

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

PHR: Program Director/Principal Investigator (Last, First, Middle): Liebermann, Erica PROJECT NARRATIVE HPV Vaccination is a critical tool for the prevention of cervical cancer and other HPV-related cancers; as such, evidence-based guidelines are to vaccinate children ages 11-12 and provide catch-up HPV vaccination for adolescents and adults up to age 26. Reaching unvaccinated college students for catch-up vaccination is an important strategy to improve HPV vaccination rates in the US. This study will explore college healthcare providers' current beliefs and practices related to assessing HPV vaccine history and offering and recommending HPV vaccination for students in their college health settings. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: LIEBERMANN, ERICA J (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: College Health Provider Attitudes and Practices Regarding HPV Vaccine

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Non-Hispanic Black adults are disproportionately impacted by both acute and chronic post-injury pain relative to Non-Hispanic Whites, yet the biopsychosocial mechanisms underlying these racial differences remain poorly characterized. This prospective study will follow adult traumatic injury patients from hospitalization across a 6- month follow-up period to determine the extent to which biobehavioral and social factors contribute to racial differences in the transition from acute to chronic pain. Enhanced scientific understanding of these mechanisms may provide a unique opportunity to begin mitigating these clinical pain disparities.

PI_NAMEs: MORRIS, MATTHEW C. (contact)

PROGRAM_OFFICER_NAME: BURNS, PAUL ANTHONY

PROJECT_TERMS: Accounting;Acute;Acute Pain;Address;Adult;Age;biobehavior;Biological Markers;biopsychosocial;black patient;Black race;Characteristics;Chronic;chronic pain;chronic painful condition;clinical pain;Cognition;Communities;cost effective;depressive symptoms;Development;Disease susceptibility;Disparity;Early Intervention;Elements;Emergency department visit;Exhibits;expectation;experience;follow up assessment;follow-up;Functional impairment;Gender;Health;Health Care Visit;Healthcare;Hospitalization;Hospitals;improved;Inflammation;Inflammatory;inflammatory marker;injured;Injury;innovation;Interleukin-1 beta;Interleukin-6;Knowledge;Life;Life Stress;low socioeconomic status;Measures;Mediation;Mediator;Methods;minority stress;Modeling;multidisciplinary;Neighborhoods;Not Hispanic or Latino;novel;Pain;pain catastrophizing;pain chronification;Pain intensity;Pain Measurement;pain outcome;pain sensitivity;Pathway interactions;Patients;Perception;Policies;post-traumatic stress;post-traumatic symptoms;predictive modeling;Prospective Studies;Race;racial difference;racial disparity;recruit;Reporting;Research Personnel;Risk;screening;Sensory;Severities;skills;social factors;social health determinants;Social support;Socioeconomic Status;Stress;Stressful Event;Surveys;Testing;theories;Time;TNF gene;trauma centers;Traumatic injury;Work

PROJECT_TITLE: Mechanisms of transition from acute to chronic pain in Non-Hispanic Black and White injury patients

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative Sensitive periods during development govern circuit refinement in sensory cortices but it is unclear whether they also govern maturation of associative cortical areas such as the prefrontal cortex. Studying prefrontal circuit maturation is important for understanding psychiatric disorders with neurodevelopmental origin and altered prefrontal cortex function.

PI_NAMEs: KELLENDONK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Amygdaloid structure;Anatomy;Area;ARHGEF5 gene;Attention;Behavior;cell type;Cognition;cognitive ability;Cognitive deficits;Corpus striatum structure;Data;density;Development;Disease;early adolescence;Etiology;imaging study;Impairment;improved;in vivo;Interneurons;Intervention;Link;Measures;Mental disorders;Mus;Neurobehavioral Manifestations;Neurodevelopmental Disorder;Neurons;Onset of illness;Outcome;Performance;Physiological;Physiology;postnatal;Prefrontal Cortex;Property;Protocols documentation;Rest;Schizophrenia;sensory cortex;Slice;Thalamic Nuclei;Thalamic structure;Time;Training

PROJECT_TITLE: Thalamo-prefrontal circuit maturation during adolescence

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Racial-ethnic socialization (RES)–or the delivery of messages that promote racial-ethnic pride and prepare youth to cope with racism–is a cultural strength that helps to buffer Latino/a/x youth from the damaging effects of racial- ethnic discrimination on mental health and conduct problems. Yet, few preventive interventions directly target parents' RES practices to address health inequities, and a RES intervention specifically for Latino/a/x families is needed. This study will develop, iteratively refine, and pilot a video-feedback intervention to bolster Latino/a/x parents' motivation to engage in RES and strengthen their RES competency (improved skills and confidence, decreased stress), with anticipated benefits on youths' racial-ethnic coping, racial-ethnic identity development, and mental health and behavioral functioning.

PI_NAMEs: GALÁN, CHARDÉE A. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 14 year old;acceptability and feasibility;Address;Adolescence;Adolescent;Adolescent Development;Adult;Aftercare;Age;Aggressive behavior;Anxiety;anxiety symptoms;arm;Behavioral;behavioral health;behavioral response;biological adaptation to stress;Black race;Buffers;caregiving;Child;Child Rearing;children of color;Clip;Cognitive;Color;Communication;Competence;conduct problem;coping;Data;depressive symptoms;Development;Discrimination;early childhood;Educational Curriculum;Emotional;ethnic discrimination;ethnic identity;Ethnic Origin;experience;Exposure to;Family;Feedback;Fostering;Frequencies;Health;health inequalities;improve minority health;improved;Inequity;Intervention;intervention effect;intervention mapping;intervention refinement;Interview;Latina;Latino;Latinx;Link;Manuals;Mental Depression;Mental Health;Methods;Minority Groups;Monitor;Motivation;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;novel;Outcome;Parent-Child Relations;Parents;Participant;Perception;Personal Satisfaction;Phase;Preparation;prevent;preventive intervention;Problem behavior;programs;psychologic;Questionnaires;Race;racial discrimination;racism;Reduce health disparities;Reporting;Research;Research Personnel;resilience;Sex Differences;skills;Socialization;Stress;stressor;Surveys;Symptoms;Testing;theories;Time;transmission process;Videotape;Violence;Youth

PROJECT_TITLE: Developing and Testing a Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency in Latino/a/x Families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE: Traumatic Axonal Injury: Tau and Amyloid Pathogenesis in vitro. Traumatic brain injury can induce chronic neurodegenerative changes as seen in Alzheimer’s disease/ Alzheimer’s disease related dementias, including tau and amyloid pathologies. While the mechanism leading to these pathologies are not well understood, traumatic axonal injury (TAI) may provide the environment for their genesis. We propose to use a clinically relevant in vitro model of axonal stretch injury to investigate the genesis and metabolism of tau and amyloid-beta in injured axons and their roles in axon degeneration or protection and repair.

PI_NAMEs: SMITH, DOUGLAS HAMILTON (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: abeta accumulation;abeta deposition;abeta oligomer;abeta toxicity;Acute;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;Animals;Axon;axon injury;axonal degeneration;beta amyloid pathology;beta-site APP cleaving enzyme 1;Binding Sites;Chronic;clinically relevant;Complex;Curiosities;Data;Deposition;Diffuse;Environment;Event;Evolution;Family suidae;Fascicle;Fostering;Functional disorder;Generations;Hour;Human;human induced pluripotent stem cells;improved;In Vitro;in vitro Model;Individual;Induced pluripotent stem cell derived neurons;inhibitor;Injury;Link;Mechanics;Membrane;Metabolism;Microtubule Stabilization;Microtubules;Modeling;N-acetylaspartate;Nerve Degeneration;neurofibrillary tangle formation;Neurofibrillary Tangles;neuronal cell body;Neurons;Outcome;Pathogenesis;Pathologic;Pathology;Pattern;Phase;Phosphorylation;Physiological;Play;Population;prevent;Process;Proteins;Recovery;repaired;response to injury;Role;secretase;Senile Plaques;Silastic;Source;Stretching;Swelling;tau aggregation;tau Proteins;tau-1;taxane;Tissues;Toxic effect;Traumatic Brain Injury;Traumatic brain injury related dementia;white matter

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: Berkeley

ORG_NAME: EYSZ, INC.

ORG_STATE: CA

PHR: Narrative Childhood absence epilepsy (CAE) is the most common pediatric epilepsy syndrome, affecting 10–17% of all children with epilepsy. Those with CAE often experience significant diagnostic delay and limited monitoring due to the difficulty in detecting absence seizures, which also limits clinical studies of new anti-epileptic drugs in this patient population. An in-home diagnostic method would reduce the wait times associated with in-clinic VEEG appointments, potentially reducing time-to-diagnosis and improving access, especially in rural and low-income areas.

PI_NAMEs: KUPERMAN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Absence Epilepsy;accurate diagnosis;Affect;Algorithms;anti-epileptic agents;Appointment;Area;Biometry;Cellular Phone;Child;childhood epilepsy;Clinic;Clinical;Clinical Research;cohort;Computer software;Data;Data Collection;Data Reporting;detection sensitivity;Development;Diagnosis;diagnosis standard;Diagnostic;Diagnostic Procedure;Electroencephalography;Elements;Epilepsy;Evaluation;experience;Eye Movements;Face;Foundations;Future;Home;Home environment;Hyperventilation;Improve Access;Low income;machine learning algorithm;Methods;mHealth;Mobile Health Application;Monitor;novel therapeutics;Outcome Measure;patient population;Patient Self-Report;Patients;Persons;Phase;Predisposition;remote monitoring;Rural;Seizures;Sensitivity and Specificity;smartphone application;social stigma;software development;Syndrome;Testing;Therapeutic Effect;Time;tool;treatment response;Validation;visual tracking;Wait Time

PROJECT_TITLE: A Mobile Health Application to Detect Absence Seizures using Hyperventilation and Eye-Movement Recordings


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The constant exposure to Staphylococcus aureus (S. aureus) does not correlate with protective immunity. Antigen processing and loading on MHCII is regulated by H2-M (DM in humans) and its inhibitor H2-O (DO in humans). Here, we find that H2-O-deficient mice mount immune responses that lead to the decolonization of S. aureus and we propose to exploit these animals to identify the underlying mechanism.

PI_NAMEs: GOLOVKINA, TATYANA V (contact);MISSIAKAS, DOMINIQUE M.

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;adaptive immune response;Affinity;Animals;Antibiotics;Antibodies;Antibody Response;antigen processing;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;B-Lymphocytes;Bacteria;Bacterial Antigens;Binding;Blocking Antibodies;Blood;Blood Circulation;CD4 Positive T Lymphocytes;Chemotaxis;commensal bacteria;commensal microbes;Complement;Complement 1q;Deposition;derepression;Disease;Effectiveness;Endosomes;Exposure to;Failure;Frequencies;Genes;Genetic;Genetic Determinism;Genetic Diseases;Genetic Recombination;genome wide association study;Genus staphylococcus;Goals;Hepatitis B Virus;Hepatitis C virus;Histocompatibility;Histocompatibility Antigens Class II;Human;Immune;Immune response;Immunity;Immunodominant Antigens;Immunoglobulin Constant Region;Immunoglobulin G;Immunoglobulins;in vivo;Infection;Infectious Skin Diseases;inhibitor;Innate Immune Response;Lead;Lesion;Life;Lysosomes;Lytic;Maps;Mediating;methicillin resistant Staphylococcus aureus;MHC Class II Genes;model organism;mouse model;Mus;neutralizing antibody;neutrophil;Operative Surgical Procedures;Organ;pathogen;Pathogenesis;Peptides;Predisposition;Production;Protein Secretion;recruit;Recurrence;Reporting;Resistance;Resolution;response;Retroviridae;Risk Factors;Role;Sepsis;Sheep;Skin;soft tissue;Soft Tissue Infections;Standardization;Staphylococcal Infections;Staphylococcal Protein A;Staphylococcus aureus;Staphylococcus aureus infection;Surface;T-Lymphocyte;Tissues;uptake;Vaccines;Wild Type Mouse

PROJECT_TITLE: Host-driven antibody responses against Staphylococcus aureus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stroke

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE (Parent Grant) Germinal matrix intraventricular hemorrhage (IVH) occurs in 15-20% of babies born before 32 weeks of pregnancy. Lifelong consequences may include post-hemorrhagic hydrocephalus (PHH), developmental delay, and cerebral palsy. We propose to use cutting-edge optical, genetic, molecular, and clinically informed approaches in our mouse model of neonatal IVH to test if two distinct and complementary endogenous responses to intraventricular blood can be harnessed to mitigate IVH sequelae: (1) ChP-NKCC1 gene therapy to remove excess CSF, and (2) macrophage clearance of ventricular blood. Our findings will give insight into the sequence and causality of events following IVH, unveil new therapeutic targets, and test the first potential gene therapy for PHH.

PI_NAMEs: LEHTINEN, MARIA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Adult;Apical;Blood;blood product;Brain;Brain hemorrhage;brain tissue;Calcium;Cell secretion;Cells;Cerebral Palsy;Cerebral Ventricles;Cerebrospinal Fluid;chloride-cotransporter potassium;Choroid Plexus Epithelium;Clinical;clinical development;Clinical Treatment;Data;Development;Developmental Delay Disorders;Embryo;Epithelial Cells;Equilibrium;Etiology;Event;Excision;experience;extracellular;Extravasation;Fluids and Secretions;FOS gene;gene therapy;Genetic;Goals;Hemorrhage;Home;Homeostasis;Hydrocephalus;Immediate-Early Genes;Immune;improved outcome;Infant;Inflammatory;insight;Intraventricular;intraventricular hemorrhage;Ions;Liquid substance;Macrophage;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Neonatal;Neurologic Deficit;new therapeutic target;novel;Optics;parent grant;Pathogenicity;Phosphorylation;Physiological;Pregnancy;Premature Infant;Process;Production;Reaction;recruit;response;Severities;Signal Transduction;Site;Structure of choroid plexus;Surface;System;Testing;Therapeutic;Ventricular;Water

PROJECT_TITLE: Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The major goal of this project is to provide access to precision-temperature-controlled environments for housing rodents undergoing studies that involve either manipulation of temperature as a component of the study or a requirement for precise maintenance of a set temperature to improve rigor and reproducibility where outcome measures are impacted by variation in ambient housing conditions.

PI_NAMEs: WARD, CHRISTOPHER S (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Address;Adipose tissue;Animal Experiments;animal facility;Animal Housing;Animals;Behavioral;Body Temperature;circadian;Climate;cohort;college;Controlled Environment;Disease;disease model;Ensure;Environment;Equipment;Goals;Homeostasis;House mice;Housing;Humidity;improved;Investigation;Lighting;Maintenance;Malignant hyperpyrexia due to anesthesia;Medicine;Metabolic;Methods;Modernization;Molecular;Nature;Neurologic;neuronal circuitry;Outcome;Outcome Measure;Outcome Study;Pathology;Pathway interactions;Physiological;Physiology;Process;programs;Publishing;recruit;Regulation;Reproducibility;Research;Research Personnel;Rodent;success;Sudden infant death syndrome;System;Temperature;Thermogenesis;Variant

PROJECT_TITLE: TSE climate chambers for precision-controlled temperature housing of rodents.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative: The Leica ARTOS 3D is an automated ultramicrotome specifically designed to create long series of sequential sections of cell or tissues to prepare the samples for three-dimensional electron microscopy methods. The ARTOS will greatly improve the efficiency of serial sectioning and permit much larger datasets than currently possible with electron microscopy sample preparation equipment on campus. There is a substantial and fundamental need for this piece of equipment to support the ongoing work of numerous NIH-sponsored grants at Vanderbilt University and Vanderbilt University Medical Center.

PI_NAMEs: KRYSTOFIAK, EVAN  (contact)

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Acoustics;Appointment;Architecture;Array tomography;Basic Science;Biological;Cancer Biology;Cells;cellular imaging;Collection;Communities;Cytoskeleton;design;Diabetes Mellitus;Direct Costs;Electron Microscopy;Electron Microscopy Shared Resource;Equipment;Fee-for-Service Plans;Funding;Grant;Image;image reconstruction;imaging capabilities;improved;Institution;instrument;large datasets;Manuals;medical schools;Metabolism;Methods;Microscopy;Microtomy;Modernization;Movement;nanometer resolution;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;Pathogenesis;Preparation;Process;Reproducibility;Research;Research Personnel;Resolution;Resource Sharing;Resources;Running;Sampling;Series;Services;Stains;Thick;Thinness;Three-Dimensional Image;Time;tissue reconstruction;Tissues;Transmission Electron Microscopy;Ultramicrotomy;United States National Institutes of Health;Universities;vibration;Work;X-Ray Tomography

PROJECT_TITLE: Acquisition of a Leica ARTOS 3D Ultramicrotome


NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Understanding the dynamic process of LLPS that results in the formation of the biomolecular condensates and the reverse process that results in their dissolution will lead us to the knowledge how important cellular behaviors such as cell migration, neurite growth and endocytosis are regulated. It is known that the stability of a biomolec- ular condensate depends on electrostatic forces as well as hydrophobic interactions between the molecules residing in the condensate, but there are no known biosensors for real-time monitoring of environmental hydro- phobicity in living cells, limiting our understanding of how hydrophobicity changes over the lifetime of biomolec- ular condensates. Here we propose to develop a genetically encoded hydrophobicity biosensor consisting of a pair of fluorescent proteins that can undergo Förster Resonance Energy Transfer (FRET), and to demonstrate that this biosensor, once partitioned to biomolecular condensates of prescribed species, will dynamically report the hydrophobicity within the condensate.

PI_NAMEs: CHEN, YUN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Address;Adipocytes;Affect;Amino Acids;analog;Anisotropy;Binding;Biochemical Reaction;biophysical properties;Biosensor;Brain;Calibration;Cancer Etiology;Cell Adhesion;cell behavior;cell motility;Cell Physiology;Cells;Central Nervous System;Coin;Complementary DNA;Coupled;cytotoxicity;design;Development;dimer;DNA Sequence;driving force;Electrostatics;Endocytosis;Energy Transfer;enhanced green fluorescent protein;Environment;Environmental Monitoring;Exclusion;Exhibits;flexibility;Fluorescence;Fluorescence Resonance Energy Transfer;Focal Adhesions;Free Energy;Future;Gene Fusion;Homeostasis;Hydrophobic Interactions;Hydrophobicity;Impairment;In Vitro;injury and repair;insight;Knowledge;Life;Lipids;Liquid substance;live cell imaging;Maps;Measurement;Measures;Microglia;migration;Molecular;molecular dynamics;Monitor;nervous system development;Nervous System Disorder;neurite growth;Neurodegenerative Disorders;Neurons;Nucleotides;Oligonucleotides;Pathology;paxillin;Peptides;Phase;Physical condensation;Process;Property;Proteins;real time monitoring;Recombinant Proteins;Recombinants;reconstitution;Reporting;Research;Role;sensor;Signal Transduction;Surveys;System;temporal measurement;Thermodynamics;Work

PROJECT_TITLE: Quantitative Hydrophobicity Sensor to Probe the Dynamics of Biomolecular Condensates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-L (96)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Dietary Supplements;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Chronic pain is a serious problem in the USA and worldwide and this international collaboration focuses on the use of interdisciplinary approaches to identify and validate novel drug targets and build pain research capacity in Cameroon and Central Africa. The scientific focus of the proposal is on identifying the compounds from analgesic medicinal plants that modulate neurons through calcium metabolism. This includes investigating Cameroonian plants used in traditional medicine, like Paullinia pinnata, that show analgesic effects in models of pain, have affinity for the calcium modulator sigma-2 (σ-2)/Transmembrane Protein 97 (TMEM97) receptor in vitro, and are capable of regulating primary sensory neurons.

PI_NAMEs: KOLBER, BENEDICT J;NGUELEFACK, TELESPHORE BENOIT;TIDGEWELL, KEVIN JOSEPH (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acacia;Address;Afferent Neurons;Affinity;African;African Traditional Medicine;Agonist;Analgesics;Animals;Area;Binding;Biological Assay;Biology;Blinded;Calcium;calcium metabolism;Cameroon;Cells;Central Africa;Chemistry;chronic neuropathic pain;chronic pain;Clinical;Collaborations;Computing Methodologies;Country;Crude Extracts;cytotoxicity;Development;Disparity;drug development;drug discovery;Education;Educational workshop;Elements;Europe;Evaluation;experimental study;Fluorescence;Fractionation;Functional disorder;Goals;Homeostasis;Human;Human Resources;Image;improved;In Vitro;in vitro Assay;in vitro testing;inflammatory pain;innovation;Integral Membrane Protein;interdisciplinary approach;interest;International;Kentucky;Knowledge;Mediating;Medicinal Plants;Membrane;Methanol;Microscopy;Modernization;Molecular;Mus;Natural Products;Neurons;Neurosciences;Neurosciences Research;New Agents;new therapeutic target;non-opioid analgesic;novel;Outcome;Pain;Pain Clinics;pain inhibition;pain model;pain outcome;pain reduction;Pain Research;painful neuropathy;Paullinia pinnata;Peripheral;Peripheral Nervous System;pharmacologic;Physiology;Phytochemical;Plant Extracts;Plants;Poison;Process;Psychotropic Drugs;Rattus;receptor;reduce symptoms;Research;Research Infrastructure;Research Personnel;Resources;Rodent;screening;screening program;Sensory;Site;Source;Spinal Ganglia;Surface;targeted agent;Testing;Texas;Therapeutic;therapy outcome;tool;Traditional Medicine;Training;training opportunity;Triage;Universities;Validation;Work

PROJECT_TITLE: From traditional medicine to innovation: Discovering novel analgesics targeting calcium modulation from Cameroonian phytochemicals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: We will examine how researchers who are conducting research projects funded by the National Institutes of Health to develop artificial intelligence in healthcare think about and put into practice ideas about diversity and representation. We will create and disseminate evidence-based guidance to support fairness in AI-HC datasets.

PI_NAMEs: CHO, MILDRED K.;MARTINEZ-MARTIN, NICOLE A (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Address;Advocate;Agreement;Algorithms;All of Us Research Program;Area;Artificial Intelligence;Biological Markers;Biomedical Research;black patient;Bridge to Artificial Intelligence;case-based;Collection;computer science;computerized data processing;Consensus;Data;Data Analyses;Data Collection;Data Science;Data Scientist;Data Set;Decision Making;Delphi Study;design;Development;Educational workshop;Ensure;Equity;ethical, legal, and social implication;Ethics;Ethnic Origin;evidence base;Exercise;Failure;FAIR principles;Funding;Future;Genetic;Goals;Health Care Research;health care settings;health disparity;Healthcare;human pangenome;implementation science;Individual;Inequality;informant;Institution;Interview;Investments;Measures;Medical Research;Medicine;member;National Human Genome Research Institute;Nature;Participant;Patient Self-Report;Patients;Performance;Policies;Population;Process;programs;Race;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Sampling;Scientist;Shapes;Structure;Surveys;synthetic data;tool;Underrepresented Populations;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Fairness in Practice: Defining and Implementing Diversity & Representation in AI datasets for Healthcare

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Clinical virology differs from human virome project (HVP) and requires new tools. This proposal responds to RFA-RM-23-018 with the development of two novel tools: a better virus purification pipeline and AIM 2, a single virion detection method to measure of how many virus particles are in a sample.

PI_NAMEs: DITTMER, DIRK P (contact)

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Address;Antigens;Back;Bioinformatics;Biological Assay;Biomass;Blood;CLIA certified;Clinic Visits;clinical diagnostics;Clinical Microbiology;Clinical Virology;Collaborations;Communities;comparative;Computers and Advanced Instrumentation;Cryoelectron Microscopy;Dedications;design;Detection;detection method;Development;Diagnostic;digital;DNA;Elements;Ensure;Environment;experience;Face;Feces;Flowers;Fluorescence;Funding;Genome;genome sequencing;Genomics;Goals;Head;Health;Herpesviridae;Heterogeneity;Hospitals;Human;human tissue;human virome;Image;Individual;Infrastructure;innovation;Laboratories;mad itch virus;Manufacturer;Measures;medical schools;Methods;molecular marker;Mouthwash;nanoparticle;next generation sequencing;novel;Nucleic Acids;Outcome;Participant;particle;Patients;Persons;Plasma;programs;Proteins;Reaction;Red Cross;Reference Standards;Reproducibility;Research;Running;Saliva;Sample Size;Sampling;SARS-CoV-2 spike protein;Specimen;Standardization;statistics;success;superresolution microscopy;System;Time;timeline;Tissues;tool;tool development;Transmission Electron Microscopy;Ultracentrifugation;Urine;Viral;viral genomics;Viral Load result;Virion;virome;Virus;virus culture;Visualization;volunteer;whole genome

PROJECT_TITLE: Concentration and single virion analysis of the virome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (50)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Guided by Fundamental Cause Theory with innovative methodologies, this proposal examines the impact of geospatial intersectional stigma and affirmation on substance use and HIV risk among bisexual Black and Latino men in Chicago and Palm Beach County. The study will first collect a cross-sectional household-based probability sample of general population adults (n= 2,000 ) before collecting a geo-targeted online survey sample of bisexual Black and Latino men (n= 600) followed by a qualitative interviews with bisexual men (n=48) and key informants (n=24). By estimating geospatial intersectional stigma scores, using ecological momentary assessments, and qualitative interviews the proposed project will examine and contextualize the impact of geospatial intersectional stigma on substance use and HIV risk outcomes using both a static geospatial model and an activity space model.

PI_NAMEs: FLORES MILLENDER, EUGENIA ;WONG, FRANK Y.;XAVIER HALL, CASEY DANIEL (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Accounting;Address;Adult;AIDS prevention;alcohol use disorder;Area;Belief;Bisexual;black men who have sex with men;Black Populations;Black race;Buffers;Chicago;Communities;Community Services;comorbidity;comparative;cooking;County;Development;Disparity;Ecological momentary assessment;Ethnic Origin;experience;Florida;General Population;Goals;Hate;health disparity;health outcome disparity;Heterosexuals;Hispanic;HIV;HIV risk;Household;Illinois;Individual;informant;innovation;internalized stigma;intersectionality;Intervention;Interview;Latino;Latino Population;Latinx;lifetime risk;Link;male health;marijuana use;marijuana use disorder;Measures;men;men who have sex with men;Methodology;Methods;minority health;minority health disparity;Modeling;Neighborhoods;Outcome;Patient Self-Report;peer;Population;population stratification;population survey;pre-exposure prophylaxis;preference;Prevention;prevention service;Preventive care;Probability Samples;Provider;Race;racism;Relative Risks;Reporting;Research;Research Personnel;residence;Resources;response;Risk;Risk Behaviors;Risk Factors;Sampling;Services;sexual identity;social;social stigma;Social support;Space Models;Substance abuse problem;substance use;Surveys;theories;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Characterizing Intersectional Geospatial Stigma and Affirmation Landscapes and Their Influence on Black and Latino Bisexual Men At Risk for Substance Abuse and HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (M1)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Childhood Obesity;Clinical Research;Eating Disorders;Mental Health;Nutrition;Obesity;Pediatric;Prevention

PHR: PROJECT NARRATIVE Children with obesity often have poorer interoceptive awareness, the ability to sense, interpret, and regulate internal bodily states like hunger. This project will examine how individual differences in interoceptive awareness relate to children’s overeating behaviors (e.g., eating in the absence of hunger), and whether dysregulation of appetitive hormones ghrelin and leptin contribute to poorer interoceptive awareness. Findings will inform whether interventions targeting interoceptive awareness may be helpful for prevention of obesity and related chronic diseases.

PI_NAMEs: HOHMAN, EMILY ERIN (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: Adult;adult obesity;Age;Attenuated;Awareness;behavior measurement;Behavioral;Body mass index;Brain;cancer prevention;cancer risk;cancer type;Cardiac;Child;Childhood;Choice Behavior;Chronic Disease;Cluster Analysis;Communication;Consumption;Cues;Desire for food;Development;Disease;Down-Regulation;Eating;Eating Behavior;eating in absence of hunger;Emotions;energy balance;executive function;Exhibits;Feeling;Food;Food Energy;Foundations;Future;ghrelin;Goals;Health;Healthy Eating;healthy weight;Hormones;Hunger;Hyperphagia;Impaired cognition;Impairment;Individual;Individual Differences;Intake;interest;Interoception;Intervention;Intuition;Laboratories;Leptin;Life;life span;Malignant Neoplasms;Measurement;Measures;Obesity;Obesity associated cancer;obesity in children;obesity prevention;obesity risk;obesogenic;Overweight;Patient Self-Report;Perception;Phenotype;Physiological;Physiology;preadolescence;Prevalence;prevent;Prevention;Prevention strategy;Process;Questionnaires;recruit;reduced food intake;Regulation;Research;response;Risk;Risk Factors;Role;saliva sample;Salivary;Satiation;Series;Signal Transduction;Stomach;Subgroup;System;Visit;Weight;Weight maintenance regimen

PROJECT_TITLE: Interoception and Obesogenic Eating Behaviors in Children

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: POCATELLO

ORG_NAME: IDAHO STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it will improve outcomes of pre-clinical research studies that inform understanding of human health and disease processes. State-of-the-art technologically advanced equipment will be used to transform operations and research outcomes in a shared animal research facility, consistent with NIH’s targeted initiative to support equipment that will enable and enhance broad-ranging research activities in a shared-use facility.

PI_NAMEs: BRUMLEY, MICHELE R. (contact)

PROJECT_TERMS: Affect;Animal Experimentation;animal facility;Animal Model;Animal Welfare;Animals;Applications Grants;Area;Behavior;Behavioral;Biological Process;biomedical facility;Biomedical Research;Caring;college;Communication;Congenital Abnormality;Core Facility;Data;Disease;drug discovery;Drug Kinetics;Environment;Environmental Risk Factor;environmental stressor;Equipment;Ethics;Evaluation;Faculty;Goals;Health;Housing;Human;Human Activities;Humidity;Immunology;improved;improved outcome;Individual;innovation;Institution;Ion Channel;Laboratories;Laboratory Animal Production and Facilities;Learning;Light;metabolomics;Methodology;Modernization;Molecular;Monitor;Neuroendocrinology;neurophysiology;Neurosciences;next generation;Noise;operation;Outcome;Outcomes Research;pre-clinical;pre-clinical research;Principal Investigator;Procedures;Process;Psychopharmacology;Public Health;Publications;Records;Reproducibility;Research;Research Activity;Research Personnel;research study;Respiratory physiology;Risk;sensor;Sensory;Sentinel;Social Behavior;sound;Source;Spinal cord injury;stress reduction;System;Technology;technology platform;Temperature;Toxicology;Training;United States National Institutes of Health;Universities;Variant;Veterinarians;vibration;welfare

PROJECT_TITLE: Using advanced technology to improve animal welfare, research outcomes, and facility operations by detecting extrinsic factors in a shared animal facility


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Project Narrative This proposal focuses on the Epstein-Barr Virus deubiquitinating enzyme, BPLF1, that removes the ubiquitin modifier from protein targets and thus affects their function. This proposed research aims to identify an inhibitor of BPLF1 which could serve as therapy for EBV associated diseases.

PI_NAMEs: WHITEHURST, CHRISTOPHER BENTON (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Affect;analog;assay development;B lymphocyte immortalization;B-Lymphocytes;Biological Assay;Burkitt Lymphoma;Cell Culture Techniques;Cell Physiology;Cell Survival;Cells;Cellular Assay;Cessation of life;Chemicals;chronic infection;combat;COVID-19 patient;Data;Deubiquitinating Enzyme;Disease;DNA biosynthesis;DNA Repair;Dose;Down-Regulation;drug discovery;drug repurposing;EBV-associated disease;Effectiveness;enzyme activity;Enzymes;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Fluorescence;follow-up;Foundations;Future;gammaherpesvirus;Generations;Goals;Herpesviridae;high throughput screening;Hodgkin Disease;Homologous Gene;Human;Human Herpesvirus 4;humanized mouse;Immune System Diseases;immunosuppressed;improved;In Vitro;Individual;Infection;Infectious Agent;Infectious Mononucleosis;inhibitor;innovation;Interferons;Knock-out;Large-Cell Immunoblastic Lymphoma;lead optimization;Libraries;Long COVID;Lymphoma;Lytic Phase;Measures;Medical;member;meter;Monitor;Multiple Sclerosis;Nasopharynx Carcinoma;novel;novel strategies;Oncogenic Viruses;Pathogenesis;Pathogenicity;Persons;Population;Process;Proteins;Reporting;Research;response;Rhodamine;Role;Running;S phase;severe COVID-19;small molecule;small molecule inhibitor;Source;synergism;targeted treatment;Testing;Therapeutic;Toxic effect;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;United States;Validation;Viral;viral DNA;Viral Genome;virology;Virus;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Targeting EBV's Deubiquitinating Activity for Therapy

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Low-income, racial/ethnic minoritized individuals with substance use disorder (SUD) face the greatest disparities in HIV treatment and prevention outcomes, including experiencing significant barriers due to structural factors, including racism and discrimination. Although long acting injectable (LAI) formulations of HIV treatment and prevention are being developed to reduce barriers to care, additional adherence support is still needed. Implementing an evidence-based, peer delivered approach to support adherence to LAI interventions may be a feasible, acceptable, and sustainable way to improve HIV treatment and prevention outcomes among underserved, minority individuals with SUD.

PI_NAMEs: MAGIDSON, JESSICA F;ROSENTHAL, ELANA SIMON (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;adherence rate;Adoption;Affect;AIDS prevention;antiretroviral therapy;Awareness;Baltimore;barrier to care;Behavior Therapy;Behavioral;Black Populations;Black race;Caring;Chronic;Clinical;Clinical Trials;Communicable Diseases;Communities;cost effective;cost effective intervention;cost effectiveness;Data;Development;Discrimination;Disparity;Economics;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Eligibility Determination;Ensure;Environment;environmental stressor;Epidemic;ethnic minority;ethnic minority population;Ethnography;evidence base;experience;Face;Feedback;food insecurity;Formulation;Health system;Hepatitis C virus;high risk;HIV;HIV anti-retroviral;HIV Seronegativity;HIV Seropositivity;HIV therapy;Housing;housing instability;implementation cost;implementation evaluation;Imprisonment;improved;Individual;Injectable;Injecting drug user;Injections;Interruption;Intervention;Knowledge;Lived experience;Low income;Maintenance;Medical;Methods;Minority;minority communities;Minority Groups;Modeling;Oral;Outcome;parole;patient engagement;Patient Self-Report;Patients;peer;Persons;pill;Population;pre-exposure prophylaxis;Prevention;probation;Problem Solving;Proctor framework;Psychological reinforcement;racial minority;racism;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Resources;Rewards;Risk;Role;Sexual and Gender Minorities;Site;skills;social;social stigma;stakeholder perspectives;structural determinants;Structural Racism;Structure;substance use;Substance Use Disorder;Therapeutic;therapy adherence;Time;tool;Toxicology;Training;transactional sex;Transportation;treatment adherence;treatment as usual;Unemployment;uptake;Urine;Viral;Viremia

PROJECT_TITLE: Peer Behavioral Activation Utilization to Address Structural Racism and Discrimination and Improve HIV Outcomes in High-Risk, Substance-Using Populations- PUSH


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed research will develop a single cell mass spectrometry method that simultaneously measures three characteristics of bacterial cells: (i) their concentrations of metals (ii) how fast they grew and on what carbon source, and (iii) how abundantly the cells expressed certain genes related to their metabolism. This is relevant for understanding growth of bacterial pathogens in circumstances where hosts try to stop their growth by denying them resources – a strategy called nutritional immunity.

PI_NAMEs: BRADLEY, ALEXANDER S (contact);CHUBIZ, LON MICHAEL

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active immunity;Bacteria;bacterial metabolism;Biological;Carbon;Cells;cellular imaging;Characteristics;cofactor;Complex;Coupled;Development;Environment;Enzymes;Exclusion;expectation;experience;Gene Expression Profile;Genes;Goals;Growth;Halogens;Heterogeneity;Homeostasis;imaging modality;improved;Individual;Infection;insight;instrument;Invaded;Investigation;Isotope Labeling;Knowledge;Label;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Metals;Methods;Methylobacterium;Microbe;model organism;nanoscale;Nature;novel therapeutic intervention;Nutritional Immunity;Organism;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Phenotype;Population;Principal Investigator;Proliferating;Reporter;Research;Resolution;Resource Allocation;Resources;response;Source;Spectrometry, Mass, Secondary Ion;stable isotope;Techniques;Testing;Time;trait;Transition Elements;Variant;Visualization;Work

PROJECT_TITLE: Connecting the bacterial metallome to cellular metabolism at single cell resolution

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Enhancers are the key units of gene expression control in humans and activate genes across vast genomic distances, yet current 3D genomics methods cannot reliably capture enhancer-promoter interactions, thus hindering our understanding of transcriptional regulation. We plan to apply our recently developed Region Capture Micro-C to profile ultra-high-resolution contact maps for selected genomic regions from three human cell types, and then use our deep learning approach CAESAR to impute the ultra-deep genome-wide chromatin contact maps for diverse human tissues, which will provide accurate quantification of E-P interactions. These E-P interactions will be integrated with NIH Common Fund GTEx and 4DN datasets in knowledge graphs.

PI_NAMEs: HANSEN, ANDERS SEJR;LIU, JIE  (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: 3-Dimensional;Area;cell type;Chromatin;Computer Models;Computing Methodologies;Data;data integration;data modalities;data platform;data portal;data resource;Data Science;Data Set;Data Sources;deep learning;deep learning algorithm;Distal;Enhancers;epigenomics;expectation;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome Mappings;genome sciences;genome-wide;genomic data;Genomic Segment;Genomics;Genotype-Tissue Expression Project;Goals;Graph;Hi-C;Human;Human Genome;human tissue;Individual;knowledge graph;Maps;Mediating;Methods;Modality;Modeling;Noise;open data;Process;promoter;Quantitative Trait Loci;Regulatory Element;Reproducibility;Research;Research Personnel;Resolution;Tissue-Specific Gene Expression;Tissues;Transcriptional Regulation;ultra high resolution;United States National Institutes of Health;Variant;Visualization;Work

PROJECT_TITLE: Ultra-high resolution 3D genome maps for multiple human tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


NIH_SPENDING_CATS: Foodborne Illness;Nutrition

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The zebrafish is a powerful model system with a large, diverse, vibrant, and growing worldwide community of researchers. We propose an integrated update and modernization plan for the Ohio State zebrafish facility in Bevis Hall to support robust and reproducible research using this model at the Ohio State University. This fish facility is used by researchers studying diverse questions in development, behavior, regeneration and cancer and the upgrade will therefore foster research that is relevant to human biology in health and disease.

PI_NAMEs: HAESEMEYER, MARTIN  (contact)

PROJECT_TITLE: Modernization of the Ohio State University Bevis Hall Zebrafish Facility


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Complementary and Integrative Health;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Solidified aggregates containing proteins that initially phase separate into liquid assemblies are hallmarks of multiple devastating neurological diseases. Novel fluorescence microscopy approaches for characterizing the physical properties of macromolecular assemblies will be applied to identify solid aggregates containing the fused in sarcoma (FUS) protein in live cells. Assessing where such solid aggregates initiate and grow is expected to reveal potential pathways for the onset of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) at the cellular level.

PI_NAMEs: MUSSER, SIEGFRIED M (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Agreement;Alzheimer's Disease;Amber;Amino Acids;Amyotrophic Lateral Sclerosis;Automobile Driving;Behavior;Binding;Biological;Biophysics;Catalogs;Cells;Cellular Stress;Characteristics;Chemicals;Chronic;Codon Nucleotides;Complex;Crowding;Cytoplasm;Cytoplasmic Inclusion;Databases;density;design;Diffusion;Disease;Dyes;Environment;Equipment and supply inventories;Eukaryotic Cell;fluidity;Fluorescence;Fluorescence Microscopy;Fluorescent Dyes;fluorophore;follow-up;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;fused in sarcoma;Genes;genetic approach;Genetic Code;Growth;Heterogeneity;implementation barriers;improved;In Vitro;in vivo;Individual;Inferior;interest;Label;Link;Liquid substance;Location;macromolecular assembly;macromolecule;Mediating;Membrane;Messenger RNA;Methods;Microscopy;Molecular;Monitor;nanoscale;Nature;Nervous System Disorder;novel;Nucleoplasm;Onset of illness;Organelles;Outcome;Parkinson Disease;Pathway interactions;Patients;Phase;Physical condensation;physical property;Physiological;Physiology;primary outcome;Process;Property;Proteins;Proteome;Reporting;response;RNA;Role;Scanning;single molecule;Site;Solid;Solubility;spatiotemporal;stress granule;Structure;Surface;System;Techniques;Technology;Terminator Codon;tool;Transfer RNA;Translating;two-dimensional;Viscosity;Work

PROJECT_TITLE: Probing Biomolecular Condensates in Live Cells using Microsecond-scale Single Molecule Rotational Diffusion Microscopy (µs-SiMRoD)


NIH_SPENDING_CATS: Aging

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE MECHANISMS OF AGING September 24 – 28, 2024 This biennial international conference series on the Mechanisms of Aging at the Cold Spring Harbor Laboratory is designed to be an interdisciplinary forum that accelerates research into the biological basis of aging, which will improve treatment for age-associated diseases and reveal mechanisms of the aging process itself. The conference is unique in the aging research field because it features selected talks from influential invited speakers combined with a large number of short talks chosen by the organizers from openly submitted abstracts, which are submitted three months before the meeting. This format provides ample opportunity for presentation of cutting-edge discoveries and for broad and diverse representation of junior scientists. The research program is augmented by mentoring and career development events that target graduate students and post-doctoral researchers.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Acceleration;age-related disease;Aging;aging biomarker;aging mechanism;aging process;aging related;Area;Asian;Autophagocytosis;Biochemistry;Biological;biological adaptation to stress;Biological Models;Biology of Aging;Cardiovascular Diseases;career;career development;career networking;Cells;Cellular biology;combat;Computational Biology;Data;design;Development;Discipline;diversity and inclusion;Elderly;Ensure;Environment;European;Event;Evolution;expectation;experience;Faculty;falls;feature selection;Fellowship;Fostering;Foundations;frontier;Genetic;Goals;graduate student;Grant;Growth;hallmarks of aging;Health;Hybrids;improved;Industrialization;Industry;Inflammaging;Influentials;Information Dissemination;insight;interest;International;Interview;Knowledge;Laboratories;Learning;Malignant Neoplasms;Mediation;meetings;Mentors;Metabolism;Minority Groups;model organism;Molecular;Molecular Biology;Molecular Genetics;Neurodegenerative Disorders;next generation;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Oral;Participant;Persons;Pharmacology;Physiology;Population;Positioning Attribute;post-pandemic;Postdoctoral Fellow;posters;Process;programs;Publishing;Quality of life;Regulation;reproductive senescence;Research;Research Institute;Research Personnel;Role;Scientific Advances and Accomplishments;Scientist;Series;Social Network;Societies;stem cells;Students;success;symposium;System;Thinking;Underrepresented Minority;virtual;Woman

PROJECT_TITLE: CSHL Mechanisms of Aging Conference (2024 - 2028)

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Contraception/Reproduction;Infertility;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PHR: Child sexual abuse (CSA) constitutes a widespread childhood violence disproportionately affecting girls that is understudied on its impacts on women’s adverse reproductive health outcomes. This study will address knowledge gaps regarding CSA’s influence on impaired fecundity, pregnancy, and birth outcomes and explore inflammation and psychosocial mechanisms in these associations.

PI_NAMEs: ASSINI-MEYTIN, LUCIANA C (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;adverse pregnancy outcome;Affect;Age;Age of Onset;Biological;Birth;burden of illness;C-reactive protein;Child;Child Abuse;Child Abuse and Neglect;child physical abuse;Child Sexual Abuse;Childhood;Chronic;cohort;Data;Data Analyses;Data Collection;Data Set;Development;Diabetes Mellitus;emotional abuse;Etiology;experience;Female;Fertility;Gestational Diabetes;girls;Gynecologic;Health;high risk sexual behavior;Hypertension;Inflammation;Interdisciplinary Study;Knowledge;Life course epidemiology;Link;Logistic Regressions;Longitudinal Studies;Mediating;Mediation;Mental Depression;Modeling;Morbidity - disease rate;National Longitudinal Survey of Adolescent to Adult Health;Outcome;Participant;Pathway interactions;Patient Care;Pattern;pediatric trauma;person centered;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Premature Birth;prevent;Prevention;prospective;Proteins;psychosocial;Recording of previous events;recruit;Regression Analysis;Reporting;reproductive;reproductive epidemiology;Reproductive Health;reproductive outcome;Research;Risk;Risk Factors;Role;Sampling;Schools;Scoring Method;Selection Bias;Severities;Sexual abuse;sexual trauma;Sexually Transmitted Diseases;Spontaneous abortion;Subfecundity;substance use;Survivors;Testing;Urine;Victimization;Violence;Woman;Women's Health;women's outcomes;women's reproductive health;Work;World Health Organization

PROJECT_TITLE: Impacts and mechanisms of child sexual abuse in women's impaired fecundity and pregnancy outcomes

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT SUMMARY/ABSTRACT Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality, with long-term physical and mental health outcomes for the affected infant. Despite efforts to predict PTB risk and improve pregnancy outcomes, the establishment of etiological pathways has been constrained by the heterogeneity of PTB. Available evidence suggests that maternal exposure to adversities and chronic stress (i.e., maternal childhood trauma, adult abuse, and psychosocial stressors) are strong predictors of PTB. At the molecular level, DNA methylation (DNAm) variation is a well-studied epigenetic marker associated with maternal exposures occurring in pregnancy, some of which can have long-lasting effects on the offspring’s health. Emerging evidence shows that DNAm is related to gestational age at birth in newborns, reflective of fetal development processes. We propose a novel examination of the infant’s DNAm to elucidate the potential biological mechanisms contributing specifically to early PTB (ePTB) (< 34 weeks’ gestation) and related neonatal outcomes in a high-risk population. We will establish whether newborn DNAm mediates the association between maternal risk factors and poorer neonatal outcomes in this group. We will also identify if increased epigenetic age acceleration mediates the relationship between maternal stressors and poorer neonatal outcomes. New knowledge of biological mechanisms influencing ePTB and neonatal outcomes will facilitate the development of timely interventions to prevent ePTB's immediate and long-term consequences, particularly in high-risk populations, and to identify newborns at higher risk of adverse health outcomes. Specifically, this study will: Aim 1. Characterize the DNA methylation profile of infants born early preterm versus those born at term. Aim 2. Examine the extent to which newborn salivary DNA methylation mediates the association between maternal psychopathology and lifetime stressors, with neonatal outcomes linked to ePTB. Aim 3. (a) Estimate the extent to which newborn salivary DNAm predicts clinical gestational age, and (b) use causal mediation analysis to examine if gestational age acceleration mediates the relationship between maternal psychopathology and lifetime stressors with neonatal outcomes. A clear understanding of the role of DNAm and other biological mechanisms associated with ePTB and gestational age may facilitate the development of early interventions related to prematurity, especially in high- risk populations.

PI_NAMEs: JUVINAO-QUINTERO, DIANA L. (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;Adult;Adverse event;Affect;age acceleration;antepartum depression;Anxiety;aspirate;Automobile Driving;Biological;biological adaptation to stress;Biological Clocks;Birth;Child;Childhood;Chronic stress;clinical predictors;cohort;cost;Data;design;Development;DNA Methylation;Early Intervention;epigenetic clock;epigenetic marker;Etiology;Exploratory/Developmental Grant;Exposure to;Fetal Development;Funding;Gestational Age;Goals;Health;Heterogeneity;high risk;high risk population;Hispanic Women;Impairment;improved;Incidence;Infant;innovation;Intervention;Knowledge;Life;Link;Literature;low and middle-income countries;Low income;Maternal Exposure;maternal risk;Measures;Mediating;Mediation;Mental Health;methylation biomarker;Molecular;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;neonatal health;neonatal morbidity;Neonatal Mortality;neonatal outcome;Newborn Infant;novel;novel marker;offspring;Outcome;Pathway interactions;pediatric trauma;Perinatal;Perinatology;Peru;Phenotype;physical conditioning;Population;postnatal;Pregnancy;Pregnancy Outcome;premature;Premature Birth;Premature Infant;prevent;Prevention;Process;programs;Psychopathology;psychosocial stressors;Research;response;Risk;Risk Factors;Role;saliva sample;Salivary;Sampling;Strategic Planning;Stressful Event;stressor;System;Trauma;United States National Institutes of Health;Variant;Woman;Writing

PROJECT_TITLE: Evaluating the role of DNA methylation changes in very early preterm birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE More than 50% of persons with Parkinson’s disease (PD) have gastrointestinal (GI) symptoms, especially constipation, which often precede the motor symptoms of PD. This proposal seeks to meticulously compare neurological and GI clinical features, GI transit, anorectal functions, enteric neuropathology, functional brain imaging (PET), the colonic mucosal metagenome, transcriptome, and epigenome and the blood exposome in persons with PD with and without constipation and in asymptomatic healthy controls. By doing so, we plan to assimilate the bigger-picture cellular networks that drive disease processes, enteric neuropathology, brain-gut dysfunctions, and the clinical phenotype in persons with PD with and without constipation.

PI_NAMEs: BHARUCHA, ADIL E. (contact);SAVICA, RODOLFO

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Affect;alpha synuclein;Biological;Biological Assay;biomarker identification;Biopsy;Blood;Brain;Brain imaging;Central Nervous System;Chemical Exposure;Chromatin;Clinic;Clinical;clinical phenotype;Colon;comorbidity;Constipation;Data;Data Analyses;Databases;Deglutition Disorders;Deposition;Disease;DNA sequencing;dorsal motor nucleus;dysbiosis;Enteral;enteric infection;Enteroendocrine Cell;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenome;Exposure to;fluorodeoxyglucose positron emission tomography;Foundations;Functional disorder;Future;Gastroenterology;gastrointestinal;gastrointestinal function;gastrointestinal symptom;Gastrointestinal Transit;gut microbiome;gut microbiota;gut-brain axis;High Performance Computing;Immunohistochemistry;Impaired cognition;in vivo;Individual;individualized medicine;Inflammation;Inflammatory;innovation;Iron;Link;Magnetic Resonance Imaging;Mass Spectrum Analysis;Metabolic;metabolome;metagenome;Microbe;microbial;micturition urgency;Morphology;Motor;motor symptom;Mucous Membrane;multidisciplinary;multiple omics;Mus;Nerve;Nerve Degeneration;neuroimaging;Neurologic;Neurology;neuron loss;Neurons;neuropathology;Nodose Ganglion;non-motor symptom;Parkinson Disease;Pathway interactions;Patients;peripheral blood;Persons;Pesticides;Physiology;pollutant;Population Study;Positron-Emission Tomography;Process;Prognosis;Protein Analysis;Questionnaires;Radiology Specialty;Resolution;Risk;Risk Factors;Shotguns;small molecule;Structural defect;Symptoms;Synapses;Systems Biology;Taxonomy;tertiary care;Time;Toxic Environmental Substances;transcriptome;Transposase;Universities;Vagus nerve structure;Vulnerable Populations

PROJECT_TITLE: Mayo Clinic Consortium for Gut Brain Communication in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NDRI-USA, INC.

ORG_STATE: NY

PHR: Project Narrative To address the ongoing nationwide crisis of overdose deaths we propose to develop technology that encourages people who use drugs to protect themselves and the people around them, and that facilitates linkage to available harm reduction services. We will collaborate with a network of community members with whom we have developed strong relationships during prior research projects and will employ a highly participatory, iterative approach to developing intervention content in English and Spanish. Our proposed intervention is designed to be readily scalable for sustainable use in urban settings nationwide, future iterations can be developed for rural populations.

PI_NAMEs: ARONSON, IAN DAVID (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adoption;Behavior;Behavioral;Benzodiazepines;Books;care providers;Central Nervous System;Cessation of life;Characteristics;Cities;Collaborations;Communities;Community Networks;community partnership;community setting;Consolidated Framework for Implementation Research;Consult;Consumption;Control Groups;Dangerousness;Data;Data Collection;Data Reporting;Death Rate;demographics;Dependence;design;Development;Drug Adulterations;Drug Monitoring;drug testing;Drug usage;Drug user;Drug Utilization;Effectiveness of Interventions;Ensure;Equity;Evaluation;experience;Exposure to;Feedback;Fentanyl;follow up assessment;follow-up;Funding;Future;Gender;group intervention;Harm Reduction;Health behavior;health literacy;Heroin;heroin use;Illicit Drugs;Image;Intervention;Interview;Language;Leadership;Learning;Life;Location;Measures;medication for opioid use disorder;member;Methodology;Methods;Morphine;Nature;Needle-Exchange Programs;New York City;novel;Opioid;opioid overdose;opioid user;Outcome;Overdose;overdose death;overdose prevention;Overdose reversal;overdose risk;Pain;Paper;Participant;Patient Recruitments;peer;personalized intervention;Persons;Pharmaceutical Preparations;Pharmacologic Substance;pill;Population;Pre-Post Tests;primary outcome;Process;prospective;protective behavior;Race;Randomized;Randomized, Controlled Trials;Records;recruit;Reporting;Research;Research Project Grants;response;Risk;Risk Behaviors;Risk Reduction;Rural Population;Sampling;scale up;screening;secondary outcome;Series;service providers;Services;skin ulcer;social stigma;Spanish/English;Standardization;Stimulant;stimulant use;substance use;substance user;synthetic opioid;Tablet Computer;Tablets;tailored messaging;Techniques;Technology;technology intervention;test strip;Testing;Text;Text Messaging;therapy design;Time;tool;treatment as usual;treatment group;Unconscious State;United States;United States National Institutes of Health;urban setting;Ventilatory Depression;Waste Products;Withdrawal Symptom;Work;Xylazine

PROJECT_TITLE: Together Against Overdose: community developed technology to encourage drug checking, distribution of harm reduction supplies, and linkage to services

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Alzheimer’s disease is a neurodegenerative disorder that disrupts memory, thinking, and behavior of millions of Americans. In this study we will characterize the functional properties of the brain’s white matter regions in typical aging and Alzheimer’s disease. Findings of this study will help to better understand brain function as an integrated system of both gray and white matter in Alzheimer’s disease.

PI_NAMEs: BISWAL, BHARAT BHUSAN (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Adult;advanced analytics;Affect;Affective;Age;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;American;Applications Grants;Atlases;Behavior;Brain;Brain Diseases;Brain Mapping;Brain region;brain volume;Characteristics;Classification;Clinical;clinical predictors;Cognition;Cognitive;Communication;Communities;connectome;Corpus Callosum;Data;Data Set;Dementia;Development;Diagnosis;Dimensions;Disease;Disease Progression;executive function;field study;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Graph;gray matter;Human;human old age (65+);imaging properties;imaging study;Impaired cognition;improved;Individual;Intelligence;Investigation;Knowledge;Language;Liquid substance;Machine Learning;magnetic resonance imaging biomarker;Maps;Measures;Memory;Memory impairment;Mental disorders;Methodology;Methods;mild cognitive impairment;Mining;Motor;neural;Neurodegenerative Disorders;neuroimaging;Neurologic;neurophysiology;neurosurgery;Participant;Pathogenesis;Pathway interactions;Patients;Phenotype;Process;Prognosis;Property;Research;response;Rest;Sample Size;Scanning;Sensory;Series;Signal Transduction;Structure;Systems Integration;Testing;Thinking;time interval;time use;trait;vector;white matter;World Health Organization

PROJECT_TITLE: Functional Networks of White Matter in Alzheimer's Disease and their Associations with Cognitive Decline

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Genetics;Human Genome;Infectious Diseases;Urologic Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative: Successful completion of the proposed study will enhance our knowledge of the role genetic variation has on the resistance, susceptibility and severity and subsequent immune responses to urinary tract infections. The results gained from this project will identify candidate genes associated with UTI susceptibility and resistance and inform the selection of novel strains of mice to be used in further investigation of UTI pathogenesis. This will provide knowledge that can translate these novel discoveries into clinical applications.

PI_NAMEs: STEERS, NICHOLAS JAMES ROBERT (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: AIDS-Associated Nephropathy;Anti-Bacterial Agents;Autoimmune Diseases;Bacterial Infections;Biological Response Modifiers;Biopsy;Bladder;Bladder Control;Brain;Candidate Disease Gene;candidate identification;cell type;Cells;chemokine;Chromosome Mapping;Circulation;Clinical;clinical application;clinical heterogeneity;Communicable Diseases;Communities;comorbidity;Complex;cytokine;Data;Disease;Escherichia coli Infections;Female;Flow Cytometry;Future;Genes;Genetic;genetic approach;Genetic study;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Greater sac of peritoneum;Growth Factor;Health;Heterogeneity;HIV;Hour;Human;Immune;Immune response;Immunity;Immunogenetics;Immunologics;immunoregulation;Inbred Mouse;Inbred Strains Mice;Inbreeding;Incidence;Infection;insight;Investigation;Kidney;Knock-in;knockout gene;Knowledge;Laboratory mice;Lung;Lung infections;Macrophage;Macrophage Activation;male;Measures;men;Modeling;Molecular;mouse model;Mouse Strains;Mus;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Peripheral;Phenotype;Play;Population;Predisposition;Proteins;Protocols documentation;Quantitative Trait Loci;Regulation;Reporting;Reproducibility;Research;Resistance;Resistance to infection;response;Role;Scientist;Severities;sex;Site;Spleen;standard of care;Susceptibility Gene;Thromboplastin;Tissues;tool;trait;Transgenic Mice;Translating;Uncertainty;Urinary tract infection;Urine;Urogenital Diseases;Urology;Uropathogenic E. coli;whole genome;Woman;Work

PROJECT_TITLE: Genetic variation influences the severity of urinary tract infections and subsequent immune responses in the bladder and remote tissues in the collaborative cross mouse model

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Project Narrative Salivary gland function is chronically impaired in Sjӧgren’s syndrome, a challenging autoimmune exocrine gland disease affecting 4 million Americans with no cure or effective therapies available. There is an urgent need to develop effective and targeted new therapeutic approaches to protect and improve salivary gland secretory function in these patients. Completion of this research project will generate critical new knowledge and insights for the development of novel, microbiome- and microbial metabolite-based therapies to prevent and treat salivary gland hypofunction caused by Sjӧgren’s syndrome and other disease conditions, thereby improving the oral and systemic health of millions of people.

PI_NAMEs: YU, QING  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Address;Advanced Development;Affect;Age;American;Animal Model;attenuation;Autoimmune;autoreactivity;B-Lymphocytes;Bacteria;Bile Acids;Biological;Biological Assay;Bromodomain;C57BL/6 Mouse;Cells;Characteristics;Chronic;combat;cytokine;Data;Development;Disease;dysbiosis;effective therapy;Epigenetic Process;Epithelial Cells;Exhibits;Exocrine Glands;fecal microbiota;fecal transplantation;Functional disorder;Gene Expression;germ free condition;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Health;Human;Immune;Immunization;Immunologics;Impairment;improved;in vivo;Inbred NOD Mice;Inflammatory;Inflammatory Response;insight;Investigation;Kinetics;Knowledge;Knowledge acquisition;Lacrimal gland structure;Link;Literature;Mediating;metabolomics;Methodology;microbial;microbiome;microbiome analysis;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;novel therapeutic intervention;Oral;Oral health;Pathogenesis;Pathology;Patients;Persons;Plasma;Population;prevent;Probiotics;protective effect;Reader;Research;Research Project Grants;Safety;Saliva;saliva secretion;Salivary Glands;Salivary Proteins;Sampling;Sialadenitis;Sjogren's Syndrome;System;Testing;Therapeutic;therapeutically effective;Tissues;transcriptome sequencing;transcriptomics;Transplantation;Tryptophan;Volatile Fatty Acids

PROJECT_TITLE: Gut Microbiome and Salivary Gland Function: Protective Actions & Key Players